SGTCid condition conc unit NRT1|YOR071C.score NRT1|YOR071C.strain.pval NRT1|YOR071C.strain.significant NRT1|YOR071C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_65 0798-0905 34.986 µM 9.87555467296601 2.65458005700041e-25 yes 1 2.65690762884198e-23 10 3602145
SGTC_2594 a-mangostin 100 µM 7.10046002623699 5.51854624219796e-14 yes 2 6.21711485074683e-13 4 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2972 9093619 59.92 µM 5.37567085154647 9.22986701555607e-09 yes 3 3.81490314637515e-08 3 25236256
SGTC_1286 0929-0070 131 µM 5.30615174668832 1.40229027845883e-08 yes 4 5.59818802224992e-08 8 1420408
SGTC_1779 st039427 55 µM 5.00301756916837 8.18196023888807e-08 yes 5 2.82198974212508e-07 6 1124498
SGTC_119 0121-0043 24.815 µM 4.97412901415025 9.63057023892759e-08 yes 6 3.27708250728216e-07 56 1092378
SGTC_343 4130-2827 29.8 µM 4.59382592723479 7.58431016848809e-07 yes 7 2.17596222184513e-06 19 1118244
SGTC_121 0557-0495 61.343 µM 4.41744253302169 1.87551250781861e-06 yes 8 4.9937806359984e-06 46 3104427
SGTC_2596 sinensetin 100 µM 4.32022849225668 3.04623032034258e-06 yes 9 7.79338622756276e-06 22 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3125 9127534 49.47 µM 4.26203841063417 4.05310025269918e-06 yes 10 1.01285306666555e-05 10 1639235
SGTC_1011 4112-3381 17.4 µM 3.98974925481973 1.47119299883971e-05 yes 11 3.30715901421797e-05 42 2877139
SGTC_1761 st044296 37 µM 3.94111302208471 1.83710091980209e-05 yes 12 4.05521988041453e-05 16 1826700
SGTC_1400 3771-8998 51.5 µM 3.60953384072067 7.82120699491009e-05 yes 13 0.00015337387807405 14 670767
SGTC_769 0302-0231 76 µM 3.55497156261456 9.81864168828431e-05 yes 14 0.000189009986065759 61 571869 YER009W NTF2
SGTC_2035 5154463 94.595 µM 3.4488190063591 0.000151493616435834 yes 15 0.000281521981573253 28 2769623
SGTC_122 0236-0016 402.397 µM 3.43497953400344 0.000160168370774176 yes 16 0.000296299290692484 58 6808838
SGTC_2413 inermin 26.06 µM 3.40668857269547 0.000179367594459227 yes 17 0.000328780546089577 79 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_288 1315-0019 35.1 µM 3.28517421822204 0.000288969953826073 yes 18 0.000509596652159675 44 6811474
SGTC_1437 4092-1038 11.6 µM 3.25546800639325 0.000323951797104789 yes 19 0.000566028251191394 37 3977136
SGTC_310 1273-0058 1.06 µM 3.24378417260507 0.000338759697501943 yes 20 0.000589765427043257 317 2734232
SGTC_349 k015-0014 24 µM 3.21669472514962 0.000375546388346077 yes 21 0.000648382500023292 50 2196908
SGTC_7 0192-1582 4.227 µM 3.18973929122885 0.000415804710770147 yes 22 0.000712005967525107 111 252616
SGTC_3252 9135871 49.47 µM 3.18862010975901 0.000417559771728381 yes 23 0.00071476803982423 34 17682838
SGTC_727 3032-0951 202 µM 3.16901779605628 0.000449435373491272 yes 24 0.000764775147536288 56 3652836
SGTC_2778 tioconazole 65.09 nM 3.16486800431054 0.000456466392836639 yes 25 0.000775766597664044 108 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1235 benzylparaben 21.5 µM 3.157668857173 0.000468906260092766 yes 26 0.000795180505103299 35 7180
SGTC_3065 9113888 49.47 µM 3.15595651018109 0.000471911012992833 yes 27 0.000799863555166559 50 16648368
SGTC_592 k241-0073 46.5 µM 3.11205414395755 0.000555314239532328 yes 28 0.000928952102584723 51 4230158
SGTC_2746 daunorubicin 9.88 µM 3.0656499285572 0.000658134301242549 yes 29 0.00108598726094109 14 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.93265330133289 0.00105796707776202 no 30 0.00168039478393511 155 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1281 0884-0031 11.8 µM 2.92036727521697 0.00110438874884956 no 31 0.0017480954227508 75 1548255
SGTC_1234 0326-0494 15.5 µM 2.91824940989785 0.00111257704451069 no 32 0.00176001337920595 57 1547813
SGTC_2276 7947513 42.08 µM 2.90499128688542 0.00116511388361135 no 33 0.00183631661957875 73 2105100
SGTC_2405 ticlatone 3.52 µM 2.88687826424087 0.00124056344030343 no 34 0.00194542369742693 138 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2089 5281248 129.67 µM 2.86036169927239 0.00135910057080973 no 35 0.00211579038306918 79 2737878
SGTC_2111 5486399 200 µM 2.85026924000179 0.00140687250922357 no 36 0.00218411174098444 116 689674
SGTC_574 1315-0397 40 µM 2.84337232219175 0.00144039528784306 no 37 0.00223194452029998 116 6794277
SGTC_2664 lyso-paf C-16 73.48 µM 2.8263801436374 0.00152612050879349 no 38 0.00235386791335514 53 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3185 9108267 49.47 µM 2.81597127398067 0.00158090548827039 no 39 0.00243150073252696 77 4910486
SGTC_1164 k060-0068 93.7 µM 2.7964959298568 0.00168824971686746 no 40 0.00258300308280805 95 5963676
SGTC_1511 0906-3109 28.5 µM 2.77168713739995 0.00183459143610333 no 41 0.00278833035537473 144 2882180
SGTC_2933 9026794 32.47 µM 2.68009055569054 0.00248024695661954 no 42 0.00368011229481553 108 17586027
SGTC_1774 st048371 48.465 µM 2.65601809622127 0.00268102916889794 no 43 0.00395346856201373 103 4242727
SGTC_511 blebbistatin 171 µM 2.65014949959295 0.0027321516182541 no 44 0.00402280801991609 91 3476986 A myosin inhibitor.
SGTC_258 haloperidol 50.781 µM 2.64618529376386 0.00276718079463508 no 45 0.00407026060207875 131 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1652 st011932 78 µM 2.61626780887698 0.00304488703637115 no 46 0.00444484012959334 86 1551076
SGTC_952 1185-0122 232 µM 2.61003425398186 0.00310581705736133 no 47 0.0045266578462474 99 678600
SGTC_1668 st014914 51.6 µM 2.58992451673543 0.00330993474530548 no 48 0.00479984894126468 66 2839556
SGTC_327 1273-0057 3.96 µM 2.56374712028451 0.00359368254935101 no 49 0.00517744789440801 98 3108138
SGTC_462 ag-879 158 µM 2.5323773033313 0.00396234464729616 no 50 0.00566460058425393 124 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1156 4092-0367 4.88 µM 2.53169016249955 0.00397078600509954 no 51 0.00567571233781443 117 1357585
SGTC_860 0443-0016 25.1 µM 2.51261700288153 0.0042116162306439 no 52 0.00599196793900033 112 5337942
SGTC_2463 5473429 200 µM 2.49219346839918 0.00448390465780916 no 53 0.00634784313687463 95 5399405
SGTC_3108 9121785 49.47 µM 2.4888566437465 0.00452985569972632 no 54 0.00640773144427189 109 17140271
SGTC_1947 st076332 61.6 µM 2.48697076598122 0.0045560114605145 no 55 0.00644179927586122 92 24208416
SGTC_1256 0570-0116 285 µM 2.48636845129139 0.00456439349018273 no 56 0.00645271362898322 118 410638
SGTC_1254 0550-0035 264 µM 2.48304622557681 0.00461087463244719 no 57 0.00651320911799935 115 15121435
SGTC_1690 st023502 41.2 µM 2.46485753859797 0.00487291778122959 no 58 0.006853386833958 88 24207482
SGTC_661 1304-0007 33.6 µM 2.44141339682531 0.00523021493002994 no 59 0.0073149484184341 119 3117130
SGTC_2825 7998094 58.44 µM 2.43683919092515 0.00530258476969942 no 60 0.00740813331288275 129 2987815
SGTC_1075 aripiprazole 15.2 µM 2.43512045686652 0.00533000669988461 no 61 0.00744341649803908 160 60795 An atypical antipschotic. YIL048W NEO1
SGTC_410 α-linolenic acid 100 µM 2.41912995149717 0.00559123705333107 no 62 0.00777884056603327 130 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_42 0133-0086 60.653 µM 2.40305800166425 0.00586519466958793 no 63 0.00812930420972864 120 162923 Model of phenazepam hydroxylation.
SGTC_681 1642-0006 26.6 µM 2.38761044947616 0.00613966427421581 no 64 0.00847915312134459 66 4446530
SGTC_986 1493-0483 84 µM 2.37850496360585 0.00630672665227318 no 65 0.00869150144615654 107 40079
SGTC_2118 5526350 200 µM 2.37748146717785 0.00632575453532576 no 66 0.00871565944931327 133 743594
SGTC_2878 9043973 25.97 µM 2.36476078184354 0.0065665212370216 no 67 0.0090208601670752 99 6465167
SGTC_2030 5175110 200 µM 2.36170890939773 0.00662547620415235 no 68 0.00909545970970371 140 2831986
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.34368249814181 0.00698334276071327 no 69 0.00954720910270461 144 5393153
SGTC_1003 4049-0218 100 µM 2.34292915307748 0.00699866299215264 no 70 0.00956650792074155 172 295161
SGTC_331 k048-0133 24.5 µM 2.34209598652572 0.00701564103707353 no 71 0.00958789127093835 101 6813582
SGTC_622 1348-1566 26.3 µM 2.33815711715773 0.00709639938993483 no 72 0.00968954957401739 148 7340407
SGTC_829 1635-0120 117 µM 2.2938955559829 0.00806185510334704 no 73 0.0108982493769179 175 285054
SGTC_1660 st012960 28.1 µM 2.29201282824425 0.0081053670517584 no 74 0.0109524514719333 170 24207266
SGTC_2154 5570129 200 µM 2.28389015795783 0.00829546576809454 no 75 0.0111889935998987 158 673366
SGTC_120 rhodamine 6G 52.259 µM 2.27489276149128 0.00851059647258776 no 76 0.0114561818424794 203 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1148 3909-7663 27.7 µM 2.26975029696349 0.00863574041071077 no 77 0.0116113688999874 140 4084526
SGTC_14 0354-0009 295 µM 2.26307945641706 0.00880048098186255 no 78 0.0118153958493995 152 1713507
SGTC_1534 6-azauridine 81.6 µM 2.25565139561339 0.00898715718279995 no 79 0.012046235876579 185 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1215 3852-0577 11.2 µM 2.25270710225798 0.00906210535158211 no 80 0.0121388114219472 153 2884876
SGTC_2026 5148700 152 µM 2.24926682961343 0.00915037181329401 no 81 0.0122477624302787 154 79838
SGTC_1623 st003709 20.3 µM 2.23261221934199 0.00958839989052409 no 82 0.0127872637986807 266 16192618
SGTC_2286 7945697 125 µM 2.22980903155278 0.00966390047714932 no 83 0.0128800617799964 207 1245733
SGTC_1301 naphtanilide LB 4.81 µM 2.22177095675982 0.00988328452196431 no 84 0.0131493942171807 152 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2285 7945142 200 µM 2.21771319908515 0.00999567607778765 no 85 0.013287196857376 171 2970608
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.19030099280052 0.0107845749421441 no 86 0.0142512074458683 204 165506
SGTC_1266 0828-0227 32.9 µM 2.18467555183156 0.0109530120446219 no 87 0.0144563219962473 169 3913820
SGTC_978 1416-0512 87.4 µM 2.18314212574728 0.0109993210853994 no 88 0.0145126725861942 197 6814003
SGTC_2483 5729050 27.16 µM 2.18133607809544 0.011054081587078 no 89 0.0145792838938696 214 2865180
SGTC_959 1222-0044 107 µM 2.17713481835107 0.0111823846520031 no 90 0.0147352549345025 176 6083612
SGTC_416 estradiol valerate 100 µM 2.17255980789735 0.0113235725513101 no 91 0.014906731834683 161 13791 A steroid.
SGTC_1019 4262-0212 3.4 µM 2.1663874515123 0.011516509028053 no 92 0.0151407960236979 253 4677213
SGTC_2837 9008476 45.46 µM 2.16492848695683 0.0115625285731422 no 93 0.0151965811248187 218 2992805
SGTC_1306 1185-0270 9.02 µM 2.15844391550933 0.0117690062365009 no 94 0.0154466672343138 190 1548076
SGTC_2581 avocatin a 64 µM 2.15423200523337 0.0119048268920986 no 95 0.015610991061338 224 6710728 A skin care supplement.
SGTC_525 k781-2675 26.7 µM 2.14147225676249 0.0123246191188083 no 96 0.0161179867166818 221 3651118 YDL195W SEC31
SGTC_474 dl-dihydrosphingosine 5 µM 2.13501928159042 0.0125417607934596 no 97 0.0163797175835777 202 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2268 7933382 153.85 µM 2.13260144488841 0.0126239694737932 no 98 0.0164787173502922 243 935025 YOR257W CDC31
SGTC_20 0481-0013 4.944 µM 2.13199465800752 0.0126446738524215 no 99 0.0165036428573302 198 182045
SGTC_916 4466-0038 42 nM 2.12595848655239 0.0128522414511778 no 100 0.0167533581480862 289 5722064 YGL116W CDC20
SGTC_3031 9088762 49.47 µM 2.12291472837234 0.0129580212253337 no 101 0.0168804990134315 185 205253
SGTC_1936 st074407 74.3 µM 2.12094718449173 0.0130267991773238 no 102 0.0169631236436384 246 809813
SGTC_2682 pyrogallin 40.03 µM 2.12039448227256 0.0130461762588902 no 103 0.0169863958198621 225 822798 An ATP competetive kinase inhibitor.
SGTC_836 0330-0104 1.35 µM 2.1143999788088 0.0132579420024712 no 104 0.0172405597378516 171 46494820
SGTC_3207 9114163 49.47 µM 2.10182218574955 0.0137119431626269 no 105 0.0177844274733082 248 849233
SGTC_1629 st005085 44.9 µM 2.0941711381578 0.0139946217951085 no 106 0.0181223689127384 229 24207091
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.0928247221903 0.0140448833465164 no 107 0.0181824020341056 171 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2678 equilin 100 µM 2.09065786187371 0.0141260986649821 no 108 0.0182793724412391 196 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1904 st060225 78 µM 2.08968526874867 0.0141626834635439 no 109 0.0183230405842188 164 66595
SGTC_928 2764-0428 58.7 µM 2.08262030382261 0.0144308957495214 no 110 0.0186429235013568 245 662578
SGTC_2170 morpholine 200 µM 2.07927902586191 0.0145592587876414 no 111 0.0187958558867117 159 121171 Reacts with secondary amines.
SGTC_1933 st074711 15.9 µM 2.07579477672363 0.0146941598072394 no 112 0.0189564678356791 232 17250958
SGTC_1767 st044992 70.3 µM 2.06932366544305 0.0149475588719548 no 113 0.0192578621693698 225 9600693
SGTC_3041 9091929 49.47 µM 2.06747782794413 0.0150205241623516 no 114 0.0193445756614923 203 25236887
SGTC_578 3460-0051 92 µM 2.06477610898523 0.0151278740009768 no 115 0.0194720946951357 215 2876744
SGTC_1804 st050076 49.1 µM 2.064274737995 0.0151478677782309 no 116 0.0194958373975227 196 3895976
SGTC_1378 2093-0007 380 nM 2.06049877296331 0.0152991771651381 no 117 0.019675441518615 212 3618014
SGTC_2337 9009472 200 µM 2.05975047017431 0.0153293165553536 no 118 0.0197112008949012 251 5742383
SGTC_2522 biochanin a 4.94 µM 2.04935292045472 0.0157534036824025 no 119 0.0202138086705026 181 5280373 A possible chelator.
SGTC_654 1124-0271 80.9 µM 2.0456643684413 0.015906248770286 no 120 0.0203947018527394 236 5403748
SGTC_2821 7996764 71.43 µM 2.04483283599552 0.0159408806485112 no 121 0.0204356706590204 263 2987135
SGTC_1912 st060209 90.8 µM 2.04047367785741 0.0161234915493519 no 122 0.0206515850615792 219 688787
SGTC_2308 7584454 197.62 µM 2.03112938167438 0.016520983732483 no 123 0.0211209358200584 246 893577
SGTC_717 1532-0246 73.2 µM 2.02709967036387 0.0166949730697672 no 124 0.021326110294787 224 9561992
SGTC_864 0469-0573 172 µM 2.01488284624828 0.0172320659868486 no 125 0.0219584628766843 199 689425
SGTC_1643 st009866 20.2 µM 2.00083887624277 0.0178676595825927 no 126 0.0227048781872769 167 3156273 YOR207C RET1
SGTC_1754 st042065 16.137 µM 1.99464707429035 0.0181541735140131 no 127 0.0230406927723082 427 1126236 YIL048W NEO1
SGTC_3311 9131146 2.8755 µM 1.99381691363146 0.0181928837264288 no 128 0.0230860332498004 314 4900406 YPR165W RHO1
SGTC_3097 9117246 49.47 µM 1.99300995020554 0.0182305796572283 no 129 0.0231301787648898 229 16423892
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.97855315525774 0.0189172645737173 no 130 0.0239331691432302 267 23665772 A membrane-active detergent.
SGTC_2476 5806916 10.51 µM 1.97854564489581 0.0189176269497282 no 131 0.0239335923121929 189 2870194
SGTC_1313 1220-0047 237 µM 1.97325298653908 0.0191744710755739 no 132 0.0242333731679997 276 3528706
SGTC_2377 9073351 62.6 µM 1.97215687356051 0.0192280325872184 no 133 0.024295850561409 235 7337946 YHR072W ERG7
SGTC_381 3461-2219 42.7 µM 1.96612768990209 0.0195249271983942 no 134 0.024641931288394 228 2883159
SGTC_1339 1486-1321 22.7 µM 1.95380598455656 0.0201438074879761 no 135 0.0253620831355862 239 3469382
SGTC_2618 avocadyne 43.43 µM 1.95069566055648 0.0203026331636547 no 136 0.0255466299453465 208 3015189
SGTC_1230 0170-0365 3.77 µM 1.95041742914392 0.0203168923670577 no 137 0.0255631930770766 376 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2513 baicalein 25.65 µM 1.93789764420573 0.0209673673630532 no 138 0.0263178557243257 228 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3030 9087619 49.47 µM 1.93048878739069 0.0213605383099408 no 139 0.0267731515929916 228 25236973
SGTC_2442 5158906 48.48 µM 1.9221501288678 0.0218104901702211 no 140 0.0272934349740525 246 1893835
SGTC_1616 st002734 56.1 µM 1.92019114356156 0.0219173500644415 no 141 0.027416879948731 283 4026101
SGTC_3212 9128307 49.47 µM 1.91937181471878 0.0219621742392065 no 142 0.0274686476588846 250 27243542
SGTC_1931 st074438 57.1 µM 1.91820074991426 0.0220263756828892 no 143 0.0275427805956775 212 2787313
SGTC_575 k072-0246 11.9 µM 1.91746640062303 0.0220667157834805 no 144 0.0275893527820876 247 6796779
SGTC_2567 aureobasidin a 60 nM 1.91507549927614 0.0221984877699983 no 145 0.0277414379429602 338 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_761 k216-0224 480 µM 1.91449668518816 0.0222304881364742 no 146 0.0277783611381303 239 1340404
SGTC_1510 1123-0200 71.5 µM 1.9138371294852 0.022266999828924 no 147 0.0278204848357649 317 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1051 3253-3903 78 µM 1.90475741299268 0.0227747988131266 no 148 0.0284058060418118 280 5509239
SGTC_2473 5854593 8.94 µM 1.90461610195658 0.0227827783661693 no 149 0.0284149959784121 198 2872951
SGTC_693 4161-2696 114 µM 1.90271079088565 0.0228905977200888 no 150 0.0285391465568498 184 805759
SGTC_939 1165-0479 45.3 µM 1.90124388256494 0.022973900966052 no 151 0.0286350378405749 282 1377347
SGTC_131 0141-0277 33.849 µM 1.89272480940027 0.0234627479257623 no 152 0.0291972376674767 279 1547771
SGTC_1053 3366-3204 134 µM 1.89028676327945 0.0236042496734754 no 153 0.0293598090630575 276 3632071 YPR165W RHO1
SGTC_1523 st012844 44.7 µM 1.88843687298935 0.0237120937533691 no 154 0.0294836625619952 259 4274103
SGTC_2741 miltefosine 3.04 µM 1.885127113958 0.0239060783894484 no 155 0.0297063390864358 194 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1927 st060202 13.8 µM 1.8707234429682 0.0247658769293333 no 156 0.0306917118547709 241 688887
SGTC_1350 1495-0454 146 µM 1.86606838714149 0.0250492383677084 no 157 0.0310158990949348 295 1069057
SGTC_3001 9076041 71.4286 µM 1.859550669781 0.0254505457888251 no 158 0.0314745620624244 232 16004211
SGTC_2383 9036125 200 µM 1.85474989148824 0.025749570136543 no 159 0.0318159752932576 203 79580
SGTC_695 3505-6186 243 µM 1.85247718886034 0.025892151418399 no 160 0.0319786651062656 251 1819379
SGTC_3073 9114972 49.47 µM 1.85083159864773 0.0259958017088615 no 161 0.0320968918259849 231 41905075
SGTC_1396 3511-0007 98.6 µM 1.83400794345246 0.0270755187772112 no 162 0.0333264075136173 242 X1396
SGTC_279 1273-0055 2.93 µM 1.82718475871884 0.0275239629354158 no 163 0.0338359973392956 288 2847562
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.82659204011738 0.0275632091551004 no 164 0.0338805655411401 315 5379071
SGTC_1777 st045864 34.765 µM 1.82440972225262 0.0277081112588315 no 165 0.034045076638272 257 4691462
SGTC_2195 6536160 144.242 µM 1.81772040915923 0.0281562303567343 no 166 0.0345534383727083 240 3834386
SGTC_342 k048-0088 23.3 µM 1.81620597196287 0.028258516250254 no 167 0.0346693911748442 277 6820570
SGTC_1800 st050079 29.0735 µM 1.80821433225598 0.0288034110565744 no 168 0.0352865744146277 486 3645560
SGTC_674 0498-0004 451 µM 1.80193903121099 0.0292373783486025 no 169 0.0357774992331158 298 4231473
SGTC_1861 st057647 17.4 µM 1.79859551059824 0.0294708078115784 no 170 0.0360413440178893 277 688668
SGTC_2764 methyldopa 94.69 µM 1.79726823488991 0.0295639002041547 no 171 0.0361465232536423 301 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.79171882114253 0.0299557721678547 no 172 0.0365890090541548 233 616764
SGTC_2164 5685496 200 µM 1.78698906245347 0.030293155568146 no 173 0.0369696281846554 277 759046
SGTC_3214 9129694 49.47 µM 1.77296334565153 0.0313121988163404 no 174 0.0381173904092594 289 17158655
SGTC_194 1486-1323 56.904 µM 1.77072005719704 0.0314777859321061 no 175 0.0383036327133861 279 5178754
SGTC_2846 9008642 19.48 µM 1.75526355472188 0.0326384776999222 no 176 0.0396071186749348 278 2992898
SGTC_2411 st077133 39.94 µM 1.75480939656094 0.0326731090434439 no 177 0.039645957891746 356 1403142 YNL221C POP1
SGTC_3052 9092717 49.47 µM 1.75383933475778 0.0327471815547838 no 178 0.039729020475297 299 25237534
SGTC_1725 st036284 20.55 µM 1.74875543383644 0.0331376484008907 no 179 0.0401666516866498 347 707914
SGTC_185 k048-0037 25.491 µM 1.74234021599209 0.0336358320701153 no 180 0.0407244651477499 284 6827589
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.74217461895051 0.0336487729293277 no 181 0.0407389468855226 286 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1838 st055369 84.5 µM 1.73548819871431 0.0341747270692219 no 182 0.0413271849986931 278 676036
SGTC_3011 9081274 71.4286 µM 1.73359096791101 0.0343251882159577 no 183 0.0414953420908846 328 6625322
SGTC_178 4092-0806 87.505 µM 1.73088423897219 0.0345407891520264 no 184 0.0417362066237874 450 2169044
SGTC_2319 6033012 152.6 µM 1.72755338222343 0.0348076296909806 no 185 0.0420341633825478 259 847246
SGTC_2737 bleomycin 30.5 nM 1.71688291487585 0.0356738756234779 no 186 0.0430002835869849 377 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3277 9138724 49.47 µM 1.71051097264791 0.0361995329567376 no 187 0.0435857130719348 222 15943418
SGTC_899 1083-0020 478 µM 1.71038957117222 0.0362096092805002 no 188 0.0435969291067664 342 767123
SGTC_1444 4112-3581 28 µM 1.70661909586063 0.0365237036991717 no 189 0.0439464367479182 302 2877249
SGTC_1603 st002045 67.8 µM 1.70645059410381 0.036537792389865 no 190 0.0439621087694798 297 5887985
SGTC_1671 st016596 74.5 µM 1.70629371230148 0.0365509135151517 no 191 0.0439767040930876 347 2829167
SGTC_886 0866-0150 153 µM 1.70620521277151 0.0365583170520812 no 192 0.0439849392720398 348 271463
SGTC_3103 9120822 49.47 µM 1.70586895335868 0.0365864584344244 no 193 0.0440162406817586 318 17141819
SGTC_81 0411-0046 9.971 µM 1.70583484687351 0.0365893137788004 no 194 0.0440194165582724 288 12925265
SGTC_255 tunicamycin 200.472 nM 1.69171701347246 0.0377869885795902 no 195 0.0453499714617566 365 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_927 2425-1185 123 µM 1.68121218677061 0.0386987630329413 no 196 0.0463608536060407 326 730375
SGTC_1805 st050013 60.3 µM 1.68121099734429 0.0386988672760049 no 197 0.0463609690807619 280 4037144
SGTC_2137 5261020 140 µM 1.6793743058515 0.0388601107407629 no 198 0.0465395588093204 343 763655
SGTC_2628 lathosterol 100 µM 1.67743278010799 0.0390311521016374 no 199 0.0467289419068006 350 6710616
SGTC_3153 9100258 49.47 µM 1.67616790384253 0.0391429124735324 no 200 0.0468526545492475 341 25236848
SGTC_2354 9060492 162 µM 1.67335150344072 0.039392696323754 no 201 0.0471290594786762 366 6471895
SGTC_87 0100-0052 35.5 µM 1.67029927010691 0.0396648586358272 no 202 0.0474300837640719 582 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2417 cerulenin 830 nM 1.66906697306695 0.0397751728073582 no 203 0.0475520538644166 293 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_621 3584-0052 32.1 µM 1.66713814487291 0.0399483404746366 no 204 0.047743469394217 338 2273927
SGTC_747 3448-8087 38.7 µM 1.66199669244865 0.0404129282396287 no 205 0.0482567188332434 362 5168703
SGTC_1125 tnp00248 1.32998 µM 1.65889712352157 0.0406951222373818 no 206 0.048568262193897 452 24207736
SGTC_1418 3966-3099 2.4 µM 1.65771483801995 0.0408031814657874 no 207 0.0486875187273001 365 740335
SGTC_892 0929-0076 29 µM 1.65140057605724 0.0413842442709601 no 208 0.0493284036466351 414 5751038
SGTC_299 1273-0059 1.44 µM 1.64631768042378 0.0418568485519681 no 209 0.0498491856264759 317 2848077
SGTC_2193 5925765 200 µM 1.64573967717126 0.041910866546046 no 210 0.0499086832148818 270 877370
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.64231886017689 0.0422317196772255 no 211 0.0502619702537237 361 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2531 methyl deoxycholate 70.07 µM 1.64005756196701 0.0424449056171444 no 212 0.0504965995514173 340 16667744 Haematoxylin.
SGTC_2229 7354935 190 µM 1.63525274994987 0.0429007733435572 no 213 0.0509980371038348 265 318112
SGTC_1375 2910-0797 186 µM 1.63101568034226 0.0433060506255793 no 214 0.0514435054582469 361 742508
SGTC_2263 7948595 193.29 µM 1.63003246276914 0.0434005363149326 no 215 0.0515473180832119 283 2971371
SGTC_2965 9082772 38.63 µM 1.62765176666289 0.0436300069959727 no 216 0.0517993729389626 376 16459634
SGTC_1550 gossypolone 36.6 µM 1.62079113706156 0.0442967700458779 no 217 0.0525312199656313 380 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1042 0350-0096 82 µM 1.6199989489834 0.0443742864005317 no 218 0.0526162513399157 347 3122515
SGTC_1845 st056753 3.01 µM 1.61867717474405 0.0445038665812331 no 219 0.0527583702268666 389 5375839
SGTC_628 1636-0253 16 µM 1.61690095733446 0.0446784780133603 no 220 0.0529498308721162 390 4456143
SGTC_2773 thioridazine 9.09 µM 1.6141028597837 0.0449546643962939 no 221 0.0532525585966902 353 5452 An antipsychotic.
SGTC_1127 asiatic acid 681.4 nM 1.61368246950743 0.0449962775402076 no 222 0.0532981591669042 370 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2150 5556613 200 µM 1.60522210943583 0.0458403524942945 no 223 0.0542224667395684 387 743190
SGTC_1289 0976-0073 69.1 µM 1.59964785456144 0.04640340648908 no 224 0.0548383629707065 377 3391136
SGTC_3217 9129673 49.47 µM 1.59699379775256 0.0466734362109394 no 225 0.0551335448809196 379 17248312
SGTC_898 1000-0849 28.3 µM 1.59461840312701 0.046916182052618 no 226 0.0553987973633015 343 6751807
SGTC_2807 7945238 51.95 µM 1.59395173151 0.0469844920828336 no 227 0.0554734231903046 397 17148797
SGTC_335 4077-0256 27.6 µM 1.59387529601189 0.0469923290851828 no 228 0.0554819842890982 415 3121989
SGTC_1739 st037196 92.5 µM 1.59279271936413 0.0471034392693215 no 229 0.0556033494883308 386 612214
SGTC_1568 digitonin 820 nM 1.59235471792696 0.0471484533225785 no 230 0.0556525123328749 415 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2533 agelasine 13.65 µM 1.59125659243339 0.0472614609164742 no 231 0.0557759206896656 412 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1630 st005209 31.3 µM 1.59034958953662 0.047354963785208 no 232 0.0558780132571423 415 3367314
SGTC_2787 5284540 71.43 µM 1.58920202265495 0.0474734787431375 no 233 0.0560073949918926 374 736958
SGTC_1588 farnesol 29.9 µM 1.58722172505636 0.0476785527028274 no 234 0.056231218012308 374 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_784 4579-0127 173 µM 1.58651398365748 0.0477520162360646 no 235 0.0563113812860047 386 1948547
SGTC_2207 7258803 200 µM 1.58175320226025 0.0482485435246331 no 236 0.0568529610540347 315 3666799
SGTC_3248 9135562 49.47 µM 1.57707289511658 0.0487406955030579 no 237 0.0573893765594653 393 17650701
SGTC_2654 protoveratrine a 100 µM 1.57537433848409 0.0489202943756815 no 238 0.0575850320340641 356 5702278 A heart drug and vasodilator.
SGTC_1401 3807-4679 7.6 µM 1.57093745409345 0.0493919288085043 no 239 0.0580985888330872 344 3291456
SGTC_2003 4023581 200 µM 1.56511826205459 0.0500159950933061 no 240 0.058777591156435 388 16641307
SGTC_2053 5265679 138 µM 1.56235766174673 0.050314240396494 no 241 0.0591018775826815 404 764595
SGTC_543 3844-1095 191 µM 1.55644250112147 0.0509580647919263 no 242 0.059801452702249 417 4230703
SGTC_1922 5578187 25 µM 1.55531977104595 0.0510810035158488 no 243 0.0599349654620451 386 1350412
SGTC_1832 st054113 55 µM 1.55180852337538 0.0514670084309417 no 244 0.0603540229562563 349 1251267
SGTC_2094 5332512 191.667 µM 1.54888562380593 0.0517901001620913 no 245 0.060704608713576 392 755774
SGTC_1187 1391-0724 117 µM 1.54768299170323 0.0519235040299297 no 246 0.0608493195116663 435 6997986
SGTC_2695 st077686 51.995 µM 1.53788644524567 0.0530203982535621 no 247 0.0620381910420332 372 2876092
SGTC_393 acivicin 6.25 µM 1.53492065534654 0.0533560694935005 no 248 0.0624016595706662 369 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_552 k242-0005 476 µM 1.5344190242528 0.0534130107987762 no 249 0.0624633001678655 357 4088318
SGTC_1182 1222-0449 220 µM 1.53331156915074 0.0535388910968092 no 250 0.0625995527143154 370 658318
SGTC_551 k048-0028 34.9 µM 1.52873744723096 0.0540613064840788 no 251 0.0631647724935676 431 6836383
SGTC_865 0488-0499 301 µM 1.52736364923705 0.0542189948653605 no 252 0.063335305143624 428 9634651
SGTC_1977 st070720 65.3 µM 1.52083417614912 0.0549734475859699 no 253 0.0641507278174315 360 682188
SGTC_1284 0929-0043 16 µM 1.51946224468675 0.0551330181515593 no 254 0.0643230922675697 436 1239883
SGTC_2860 9025725 38.96 µM 1.51817387820086 0.0552832021437389 no 255 0.0644852854015526 364 40546248
SGTC_2827 7993847 71.43 µM 1.51575990356446 0.055565467169551 no 256 0.0647900371188456 353 2985692
SGTC_460 trequinsin 123 µM 1.51529491271591 0.0556199687986828 no 257 0.0648488680373098 402 5537 A vasodilator.
SGTC_3083 9117465 49.47 µM 1.51464015441924 0.05569678461888 no 258 0.06493177875438 423 16420915
SGTC_3300 9124615 50.48 µM 1.51111718725144 0.0561115349707982 no 259 0.0653792982291735 414 24824903
SGTC_1248 0469-0687 58.6 µM 1.50993490693204 0.0562512664947429 no 260 0.065530017262736 429 4017482
SGTC_686 1319-0111 510 µM 1.50863315274743 0.0564054355774201 no 261 0.0656962785253532 445 4562600
SGTC_2981 9013952 38.96 µM 1.50516488414605 0.0568178147335105 no 262 0.0661408454316938 407 2996344
SGTC_1673 st016611 27.3 µM 1.50381754852708 0.0569786526698097 no 263 0.0663141757204796 445 5226799
SGTC_2070 5230947 200 µM 1.50376634200617 0.0569847725024146 no 264 0.0663207702025201 413 2835538
SGTC_2019 4016004 108 µM 1.50372434877477 0.0569897916155934 no 265 0.0663261785569971 369 45595336
SGTC_360 0957-0399 1.01 µM 1.50301340789781 0.0570748174985825 no 266 0.0664177932600735 448 6752301 YPR165W RHO1
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.50003834133369 0.0574317081790146 no 267 0.066802235534301 463 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1749 st037932 54.2 µM 1.4992746575211 0.0575236027221122 no 268 0.0669011969995695 412 594497
SGTC_2507 purpurin 79.67 µM 1.49911629383041 0.0575426731932833 no 269 0.0669217326446092 448 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2255 7941087 197.44 µM 1.4936832790108 0.0581999444696632 no 270 0.0676292104826841 472 935561
SGTC_3055 9094636 49.47 µM 1.48371157941832 0.0594216258018213 no 271 0.0689427265045702 395 25236176
SGTC_1961 st076550 68.7 µM 1.4832956431634 0.0594730176319698 no 272 0.0689979397019815 384 1579337
SGTC_46 0329-0187a 2.197 µM 1.48296779670817 0.0595135498998732 no 273 0.069041483487579 538 46494817
SGTC_2249 haloperidol 116.36 µM 1.47990519695861 0.059893231393109 no 274 0.0694492742934544 575 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_449 xestospongin c 11.1929 µM 1.4770823458228 0.0602448682392155 no 275 0.0698267826250022 468 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2318 6029776 164 µM 1.47643166861854 0.0603261505099615 no 276 0.0699140231999468 462 818325
SGTC_2443 5493264 126.67 µM 1.47422496210569 0.0606024504468854 no 277 0.0702105155163418 421 5340055
SGTC_630 4356-0227 183 µM 1.4675807580973 0.0614403458012348 no 278 0.0711090689470463 418 779312
SGTC_702 1488-0190 94 µM 1.46707507574895 0.0615044857426877 no 279 0.0711778167358583 405 949357
SGTC_1357 1503-1303 39.5 µM 1.46704092535096 0.0615088192090093 no 280 0.0711824613398709 498 292895
SGTC_2369 9071472 200 µM 1.46479139514081 0.0617947957095862 no 281 0.0714889201297745 455 17296037
SGTC_1455 4262-0120 131 µM 1.46320238791305 0.0619974265137034 no 282 0.0717060037992888 440 1529587
SGTC_1489 4065-0444 182 µM 1.45909858163294 0.0625231442487213 no 283 0.0722689882880279 428 2877968
SGTC_2870 9038528 12.99 µM 1.45754318192016 0.0627233044228979 no 284 0.0724832502793749 406 6463316
SGTC_3251 9135047 49.47 µM 1.4564060938538 0.0628699489270595 no 285 0.0726401959856022 363 17682963
SGTC_2765 myclobutanil 7.74 µM 1.45501484198236 0.0630497348495738 no 286 0.0728325763201254 455 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1885 st057546 99.9 µM 1.45300716382849 0.0633098846449394 no 287 0.0731108824909748 470 702008
SGTC_529 4076-0302 30.3 µM 1.45111967515516 0.0635552219919228 no 288 0.0733732693627428 450 5816522
SGTC_88 0180-0332 8.668 µM 1.44683817667467 0.0641144768488863 no 289 0.0739711258171373 453 3101745
SGTC_1493 4348-0038 111 µM 1.44446182974852 0.0644265251530843 no 290 0.0743045546473302 484 800424
SGTC_2817 7995342 71.43 µM 1.44145718090872 0.0648227662500506 no 291 0.0747277829636594 381 18879975
SGTC_1696 st025591 34.7925 µM 1.43827603912988 0.0652443419608979 no 292 0.0751778738145602 478 2787147
SGTC_2657 nystatin 74.44 µM 1.43589703132893 0.0655610040480982 no 293 0.0755158216844567 472 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1967 st070177 51.4 µM 1.43518959333911 0.0656553983700565 no 294 0.0756165391440444 409 5729214
SGTC_2580 diallyl disulphide 81.36 µM 1.4332882683945 0.0659096166656538 no 295 0.0758877366153691 426 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_274 sirtinol 40.1 µM 1.43181182936727 0.066107550858711 no 296 0.0760988404555443 463 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2506 ethyl hematommate 54.16 µM 1.43101056334692 0.0662151626845819 no 297 0.0762135938569702 386 3940691 An allergen.
SGTC_1962 st076595 64.5 µM 1.42747359880625 0.0666918069812594 no 298 0.0767217149092414 469 279619
SGTC_1195 1502-0147 41.1 µM 1.42629583545151 0.0668511112840646 no 299 0.0768914831106358 491 817940
SGTC_2735 sertaconazole 140 nM 1.42574903783329 0.0669251711398204 no 300 0.0769703980246102 374 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_968 1309-0633 340 µM 1.41862642337265 0.0678956861812569 no 301 0.0780039790699875 457 3761976
SGTC_1421 4029-0249 71.4 µM 1.41786795378357 0.067999670961918 no 302 0.0781146600103998 501 2894095
SGTC_734 2023-0417 80 µM 1.41731807667199 0.0680751349548197 no 303 0.0781949762085375 484 3935732
SGTC_408 cantharidin 100 µM 1.41510465648028 0.0683795542037563 no 304 0.0785189065674138 503 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3016 9080866 49.47 µM 1.40785933967114 0.0693833767697247 no 305 0.0795863625429116 496 17066299
SGTC_2260 7964312 200 µM 1.40691771466644 0.0695146659771682 no 306 0.0797258950194597 430 231951
SGTC_336 4111-0029 111 µM 1.4032795881731 0.0700237219212852 no 307 0.0802667412586349 400 3131175
SGTC_743 1275-0778 158 µM 1.39489277947174 0.0712081480515084 no 308 0.0815240874176316 509 2849257 YMR203W TOM40
SGTC_2561 acetosyringone 100 µM 1.39210795590016 0.0716048176589178 no 309 0.0819448547114554 551 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2144 5628481 200 µM 1.38825961301575 0.0721557620510809 no 310 0.0825290027725627 426 2818399
SGTC_523 1934-0222 13.7 µM 1.3878695841585 0.0722117810161768 no 311 0.082588380579567 501 1361595
SGTC_1171 0368-0077 21.4 µM 1.38749625570344 0.0722654325566257 no 312 0.0826452460401827 445 3239779
SGTC_1014 4130-3005 69.3 µM 1.38609686281382 0.0724668131065223 no 313 0.0828586641001663 518 743608
SGTC_1427 4048-4900 550 nM 1.3856058015355 0.0725375814097685 no 314 0.0829336528756188 487 24132586
SGTC_2421 5690543 90.72 µM 1.38551425197952 0.0725507807415186 no 315 0.0829476388303754 487 3397993
SGTC_3258 9138477 49.47 µM 1.38431773680299 0.072723459788785 no 316 0.0831305926843854 456 4970355
SGTC_1500 4488-1866 171 µM 1.3782776197209 0.0735999671561093 no 317 0.0840587951510251 533 2900003
SGTC_1049 3226-0134 66 µM 1.37614249609677 0.0739117288959612 no 318 0.084388760515521 534 5702385
SGTC_2138 5575593 77.673 µM 1.37201319894638 0.0745175331339568 no 319 0.0850296644786561 422 762213
SGTC_751 0833-0568 350 µM 1.37075150247051 0.0747033890716098 no 320 0.0852262169161247 492 6954252
SGTC_1080 nisoldipine 24.4 µM 1.36429906269284 0.075659409066648 no 321 0.0862367303947869 543 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1986 st071812 45 µM 1.36030226601024 0.0762562486286341 no 322 0.086867145800554 445 11838594
SGTC_931 2812-0076 566 µM 1.35797128931897 0.0766059825663965 no 323 0.0872363972725812 526 3450959
SGTC_1724 st037281 8.293 µM 1.35718254335464 0.0767245998767945 no 324 0.0873616080133746 531 574124 YDL195W SEC31
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.35650435386054 0.0768267025342446 no 325 0.0874693755156186 449 279621
SGTC_1704 st028805 70.8 µM 1.35644686087004 0.0768353629558216 no 326 0.0874785159825077 495 2876101
SGTC_47 0149-0135 24.25 µM 1.35293156876204 0.077366298105256 no 327 0.088038746516307 472 5239155
SGTC_2706 st078239 82.5 µM 1.34900470681245 0.0779626851138459 no 328 0.0886677271342059 502 15434492
SGTC_1900 st060200 72.8 µM 1.34487072215946 0.0785942910020374 no 329 0.0893334932764403 513 688945
SGTC_2197 6588183 93.1375 µM 1.3443058243706 0.0786808985696299 no 330 0.0894247564614562 456 884136
SGTC_2679 rapamycin 1 nM 1.34294099009424 0.0788904472211185 no 331 0.0896455411330925 626 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3124 9127567 49.47 µM 1.33618759631027 0.0799335495724096 no 332 0.0907439821201541 488 17592030
SGTC_1153 4055-0057 267 µM 1.33254348112458 0.0805007201156079 no 333 0.0913408316696762 526 882706
SGTC_2587 piperic acid 92.2 µM 1.33059044359765 0.0808059397439985 no 334 0.0916619043280996 470 5370536
SGTC_2244 6635614 200 µM 1.32566522120145 0.0815795300593405 no 335 0.0924753061054032 382 836499
SGTC_1740 st038286 13.222 µM 1.31751478125182 0.0828719430198146 no 336 0.0938330648724802 537 716786
SGTC_2007 4011539 71.82 µM 1.31749168381474 0.0828756273357595 no 337 0.0938369334069504 538 45595301
SGTC_225 nsc-122657 1.016 µM 1.31629316854382 0.0830669739165622 no 338 0.0940378314388105 387 275685
SGTC_2526 patulin 37.61 µM 1.31521016188192 0.0832401647969985 no 339 0.0942196404375611 608 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_18 0111-0177 500 nM 1.31219227830073 0.0837242070801396 no 340 0.0947276332801846 647 721752
SGTC_3197 9113331 49.47 µM 1.3112556889543 0.0838748569765261 no 341 0.0948856967263586 547 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1050 3232-1156 69.3 µM 1.30959005496823 0.0841432761335027 no 342 0.0951672772898971 546 700529
SGTC_2888 9058547 12.99 µM 1.3092824727047 0.084192913883891 no 343 0.0952193422608567 446 16476514
SGTC_1038 k292-0204 154 µM 1.30746313035903 0.0844869696784055 no 344 0.0955277344262457 503 4454212
SGTC_964 1287-0107 19.4 µM 1.30665744519548 0.0846174364623544 no 345 0.0956645386989981 584 51516812 YPR165W RHO1
SGTC_920 mycophenolic acid 780.421 nM 1.30300787520148 0.0852103142979431 no 346 0.0962860364864464 549 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1467 k284-1082 293 µM 1.30287960326894 0.0852312087331037 no 347 0.0963079342115927 569 3334705
SGTC_251 melphalan 456.522 µM 1.30218082421444 0.0853451014747714 no 348 0.0964272893740244 607 460612 A DNA alkylator.
SGTC_999 SEC7.066 22.7 µM 1.29954103199906 0.0857763854233833 no 349 0.0968791607520287 580 740511 YDR170C SEC7
SGTC_443 clozapine 122 µM 1.29838588469959 0.0859656233922442 no 350 0.0970773835457215 453 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_881 0833-0569 170 µM 1.29768070596024 0.0860813003043824 no 351 0.0971985381637443 559 5418700
SGTC_990 3985-0011 41.3 µM 1.29608612639551 0.0863433030937222 no 352 0.0974729070842994 484 5399565 YGL099W LSG1
SGTC_506 n9-isopropylolomoucine 153 µM 1.29431463830763 0.0866350721763419 no 353 0.0977783811061501 530 6610355
SGTC_3201 9113999 49.47 µM 1.29280751767614 0.0868838788299069 no 354 0.0980388198387897 541 16649224
SGTC_633 0437-0093 97.7 µM 1.28387940546317 0.088368755816476 no 355 0.0995920771158436 525 2831118
SGTC_2801 7907800 81.82 µM 1.28339568829561 0.0884497418588867 no 356 0.0996767418513062 588 6620925
SGTC_2221 6807166 181.081 µM 1.2811691873841 0.0888232255475261 no 357 0.100067123172787 462 674925
SGTC_2110 5483698 200 µM 1.27949972686162 0.089104038090256 no 358 0.100360567868953 541 2848765 YHR062C RPP1
SGTC_2194 5927483 104.545 µM 1.27893284145883 0.0891995414786575 no 359 0.100460353230662 610 760979
SGTC_2484 5809818 12.04 µM 1.27615772294634 0.089668166018528 no 360 0.100949885032599 564 2870548
SGTC_1919 st067113 52.3 µM 1.26805162762758 0.0910474939085605 no 361 0.102389757138364 587 1268243
SGTC_190 3970-0790 3.722 µM 1.26667584279805 0.0912831504238558 no 362 0.102635610613344 527 2832352
SGTC_165 k038-0023 64.381 µM 1.26588216799464 0.0914193035482137 no 363 0.102777635746038 604 46368543
SGTC_1945 st075991 56.6 µM 1.2658723399489 0.0914209904703518 no 364 0.102779395332761 544 1084980
SGTC_710 3448-4187 58 µM 1.26388549377644 0.0917624941106574 no 365 0.103135564586914 673 3946412
SGTC_2430 5571206 200 µM 1.26196525177943 0.0920934468331107 no 366 0.103480645115778 642 1731771
SGTC_1564 D-Arginine 115 µM 1.26133393878382 0.0922024461034427 no 367 0.103594279188429 562 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1124 fisetin 1.16336 µM 1.25735935493615 0.0928908713653388 no 368 0.104311770037181 519 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1410 3909-8106 77.9 µM 1.24368490688987 0.0952884078432961 no 369 0.106807776512475 564 1039210
SGTC_643 k048-0106 28.4 µM 1.23987134041199 0.0959650941700261 no 370 0.107511492927017 596 6763920
SGTC_584 0986-0246 15.4 µM 1.23766541149548 0.0963581280932652 no 371 0.107920074673081 652 53315 YDR232W HEM1
SGTC_196 k015-0023 18.111 µM 1.23722481630512 0.0964367711848122 no 372 0.108001815433773 626 5211998
SGTC_1949 st076024 69.1 µM 1.23572755993302 0.0967043731920422 no 373 0.108279924805919 578 2921930
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.23196549382143 0.0973791666669646 no 374 0.108980987089101 612 688669
SGTC_25 0118-0223 35.662 µM 1.22702026567326 0.0982714272132736 no 375 0.109907487044524 576 5333628
SGTC_1675 st018485 24.5 µM 1.22627828822032 0.098405816136747 no 376 0.110046984465002 602 3323024
SGTC_1707 st032323 6.317 µM 1.22595633096723 0.0984641717367915 no 377 0.110107554386374 623 3132057 YMR211W DML1
SGTC_617 3770-0098 35 µM 1.22487216653173 0.0986608657141199 no 378 0.110311694443866 567 5962639
SGTC_2900 5328528 85.29 µM 1.22484440073112 0.098665906884571 no 379 0.110316926098643 644 795359
SGTC_84 0443-0269 128.823 µM 1.22346308864341 0.0989169365393071 no 380 0.110577418691315 617 6150058
SGTC_2646 retinol 96.75 µM 1.22306440441703 0.0989894773452716 no 381 0.110652685862363 583 445354 A vitamin A analog and teratogen.
SGTC_2727 riluzole 51.77 µM 1.21521331709733 0.100425924531315 no 382 0.112142371280827 562 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2183 6420625 130.508 µM 1.21505878975762 0.100454348926496 no 383 0.112171834853919 678 2897619
SGTC_34 0469-0683 81.75 µM 1.21364031681065 0.10071554298117 no 384 0.112442552199219 598 3690923
SGTC_2798 7813637 45.45 µM 1.20832533160166 0.101698635883681 no 385 0.113461074186654 607 956368
SGTC_2401 5128683 200 µM 1.2057003950761 0.10218672987967 no 386 0.113966516324049 561 708373
SGTC_795 0685-0265 78 µM 1.20534806687203 0.102252373067104 no 387 0.114034480468085 625 302754
SGTC_1041 0206-0046 107 µM 1.20490902112483 0.102334215743698 no 388 0.114119212836476 617 50494
SGTC_1096 rimcazole 32.2 µM 1.20367262000777 0.102564949687019 no 389 0.114358069447728 566 18528119 A dopamine reuptake inhibitor.
SGTC_2325 6158266 200 µM 1.2011905709602 0.103029284388606 no 390 0.114838643070195 594 3623240
SGTC_1018 4259-0013 28.1 µM 1.19724547055516 0.103770461767293 no 391 0.115605445748831 600 6801262
SGTC_3205 9113483 49.47 µM 1.19666067398345 0.10388065753007 no 392 0.115719420528215 661 17018033
SGTC_3274 9138298 49.47 µM 1.19575966185474 0.104050605245912 no 393 0.115895180772394 647 17015756
SGTC_1736 st036774 51 µM 1.19531781031878 0.104134020330166 no 394 0.115981441891926 652 1272247
SGTC_2204 7233102 200 µM 1.19297486271486 0.104577144611375 no 395 0.116439608963715 542 2172480
SGTC_2187 6125751 200 µM 1.19125581712072 0.104903137288779 no 396 0.116776586596127 636 874498
SGTC_3148 9097893 49.47 µM 1.18930579482868 0.105273821333034 no 397 0.117159677925101 601 17174100
SGTC_2714 st079313 56.9 µM 1.18726558045153 0.105662663669487 no 398 0.117561440083873 600 2939799
SGTC_2890 9046729 58.44 µM 1.18696797585733 0.105719470492716 no 399 0.117620126253395 555 903329
SGTC_755 1995-0008 37.3 µM 1.18468517451969 0.106155946410941 no 400 0.118070973167996 662 689533
SGTC_2700 st077718 96.8 µM 1.18123557124917 0.106817984578904 no 401 0.118754576996877 583 904970
SGTC_944 3370-0224 231 µM 1.18019151837578 0.107018942318471 no 402 0.118962025817035 630 4580514
SGTC_3294 9122953 26.2835 µM 1.17953452058516 0.107145539984778 no 403 0.119092699566811 647 16459826
SGTC_2045 5106652 78.05 µM 1.17926467861138 0.1071975674226 no 404 0.119146399205092 620 673349
SGTC_2552 juarezic acid 87.02 µM 1.1786582011723 0.107314567030306 no 405 0.119267153029428 737 1549512
SGTC_1619 st003326 88.7 µM 1.17707172070651 0.107621060879678 no 406 0.119583440612423 598 2849032
SGTC_1502 4534-4282 27.7 µM 1.17682323069716 0.107669124003676 no 407 0.119633034194333 605 3278949
SGTC_74 000s-0487 160.283 µM 1.17500176307727 0.108021905838359 no 408 0.119997005218022 616 677548
SGTC_1866 st057638 64 µM 1.17420829735357 0.108175844241366 no 409 0.120155801689862 635 688802
SGTC_2389 9091542 195.52 µM 1.17332534792803 0.108347328720996 no 410 0.120332680555852 668 3626624 YOL127W RPL25
SGTC_1066 ketoconazole 628 nM 1.17112494932874 0.108775536260822 no 411 0.120774278326748 702 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_126 0417-1624 672.48 µM 1.17076729217465 0.108845252780579 no 412 0.120846164138869 788 41912 YDL195W SEC31
SGTC_577 r071-0003 38.6 µM 1.17054640484694 0.10888832540985 no 413 0.120890575507248 788 4568517 YMR134W ERG29
SGTC_478 N-arachidonylglycine 10 µM 1.16960122999761 0.109072771195544 no 414 0.121080741064659 506 5283389
SGTC_1581 himbacine 57.9 µM 1.16551221349266 0.109873307687977 no 415 0.121905859659523 673 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2456 5770359 74.46 µM 1.1614518439262 0.110672399619962 no 416 0.122729098008654 669 3118787
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.16100056889454 0.110761468307743 no 417 0.122820834046424 739 5024745
SGTC_593 1203-0218 61.7 µM 1.15970000551612 0.111018449333848 no 418 0.123085483971259 684 3666956
SGTC_2950 9072895 21.46 µM 1.15655847623946 0.11164095149648 no 419 0.123726397744639 661 17332245
SGTC_648 0375-0473 33.3 µM 1.15489509451688 0.11197156423867 no 420 0.124066694244384 694 1713139
SGTC_1020 4335-0961 93.3 µM 1.15316210510598 0.112316756149487 no 421 0.124421927163014 606 669075
SGTC_1963 st076565 50.3 µM 1.15169634913653 0.1126093112181 no 422 0.124722936517672 646 4914280
SGTC_1728 st035614 33.7865 µM 1.14721837337147 0.113506455206896 no 423 0.125645689900264 735 15945546
SGTC_3082 9117008 49.47 µM 1.14688093853752 0.113574264797468 no 424 0.125715415840529 668 41448529
SGTC_90 0870-0863 4.608 µM 1.14620328756776 0.113710530132042 no 425 0.125855523962712 708 1738164
SGTC_826 1683-5028 118 µM 1.1459468644655 0.113762123309664 no 426 0.125908569261952 654 722377
SGTC_2635 hydroquinidine 100 µM 1.14547093234274 0.113857926647113 no 427 0.126007064901102 672 442912 An experimental heart treatment.
SGTC_1818 st052136 56.3 µM 1.14525177130879 0.113902062263052 no 428 0.126052439022476 648 674169
SGTC_415 dibenzyl ketone 100 µM 1.14483164190387 0.113986703858505 no 429 0.126139452583899 703 7593
SGTC_2087 5276107 200 µM 1.14368647999975 0.114217642030177 no 430 0.12637684116742 666 144405
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.14005331658587 0.114952526038224 no 431 0.127132044640145 664 7104
SGTC_1822 st052468 42 µM 1.13737419674814 0.115496584594319 no 432 0.127690944684991 629 2873678
SGTC_753 1322-0200 289 µM 1.13619121900259 0.115737397565142 no 433 0.127938272359106 685 5403907
SGTC_1799 st045822 46.1415 µM 1.13153826057465 0.11668803670467 no 434 0.128914304598221 667 3674992
SGTC_1719 st032227 49.2 µM 1.13046961523439 0.116907149660708 no 435 0.129139197346561 653 3125804
SGTC_1839 st053978 48 µM 1.12891642556544 0.117226132315668 no 436 0.129466545495688 664 3788398
SGTC_3255 9139072 49.47 µM 1.12752850523035 0.117511694354122 no 437 0.129759547739466 674 17646060
SGTC_3324 9138759 60.749 µM 1.12736289353357 0.117545801515566 no 438 0.129794540473356 673 45595710
SGTC_2399 5884133 200 µM 1.12557155749897 0.117915168960928 no 439 0.130173456382988 653 722445
SGTC_2962 9082311 13.18 µM 1.12126754243636 0.118805996995039 no 440 0.131086998543945 636 16459453
SGTC_1640 st009078 66.4 µM 1.12049746399517 0.118965884846016 no 441 0.13125091634047 613 690618
SGTC_923 1900-2434 73.3 µM 1.11939508247254 0.119195031612819 no 442 0.131485813967902 670 5910570
SGTC_659 k018-0002 107 µM 1.11932546623647 0.119209512857752 no 443 0.131500657668484 703 6797879 YHR007C ERG11
SGTC_1237 0330-0133 46.1 µM 1.1184418009074 0.119393436732226 no 444 0.131689174931971 662 X1237 YHR072W ERG7
SGTC_1150 3909-7983 10.9 µM 1.11673744505633 0.119748742391272 no 445 0.132053301212722 705 23965914
SGTC_3171 9103192 49.47 µM 1.11661562180368 0.119774167306321 no 446 0.132079354643839 671 13018434
SGTC_3081 9117243 49.47 µM 1.11366751807275 0.120390607235628 no 447 0.132710924549878 669 45595589
SGTC_3128 9127691 49.47 µM 1.11186834844109 0.120767904595242 no 448 0.133097379685999 580 41316314
SGTC_859 0439-0102 54.6 µM 1.10605247094493 0.121993222055001 no 449 0.134351904507103 765 610143
SGTC_2655 perillic acid 100 µM 1.10487358960403 0.122242655113605 no 450 0.134607183867283 649 5702197 An apoptosis inducer.
SGTC_232 clozapine 119 µM 1.10305942228475 0.122627203900704 no 451 0.135000680432038 690 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1102 cgs 12066b 26.1 µM 1.10261939350554 0.12272060448247 no 452 0.135096242333543 677 6438352 A 5-HT1B full agonist.
SGTC_439 amiodarone 34.4 µM 1.10212381281192 0.122825856254324 no 453 0.135203924080213 726 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2743 auranofin 4.32 µM 1.10078547078112 0.123110410525247 no 454 0.135495018346884 681 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_791 1348-1292 225 µM 1.09863077667665 0.123569505337247 no 455 0.135964573880528 794 5437054
SGTC_363 0455-0021 3.06 µM 1.09843068246215 0.1236121996288 no 456 0.136008235302219 720 4597466
SGTC_98 0074-0023 107.663 µM 1.09825405230789 0.123649895954743 no 457 0.13604678473984 743 3563821
SGTC_260 nsc-65238 3.989 µM 1.09692931659988 0.123932877031307 no 458 0.136336146011318 680 3246252
SGTC_226 1,3-diallylurea 8.28947 mM 1.0955960091448 0.124218146494811 no 459 0.136627804486236 661 74537 YKL182W FAS1
SGTC_2185 6113692 200 µM 1.09236207385715 0.124911974365412 no 460 0.137336993094206 658 874150
SGTC_2508 celastrol 40.54 µM 1.09175570013579 0.125042370263861 no 461 0.137470247704505 649 122724 Celastrol is a natural product and antioxidant.
SGTC_314 1671-0008 2.74 µM 1.09026213967396 0.125363954097752 no 462 0.137798843816329 752 3913060
SGTC_787 4152-0075 138 µM 1.08814460468238 0.125820876916855 no 463 0.138265637542372 690 9566539
SGTC_368 fentichlor 4.58 µM 1.08764932374292 0.125927916305971 no 464 0.138374973653094 632 7329 A pesticide.
SGTC_3173 9105693 49.47 µM 1.08441928155878 0.126627545767185 no 465 0.139089469202067 739 17096658
SGTC_793 0488-0545 106 µM 1.08249711821859 0.127045170256776 no 466 0.139515847607872 729 292548
SGTC_2907 7721985 69.9 µM 1.08197526030474 0.127158718516739 no 467 0.139631760530151 689 3267881
SGTC_2267 7931562 200 µM 1.08147319171727 0.127268027552175 no 468 0.139743339719455 649 934880
SGTC_2723 salbutamol 83.58 µM 1.07756096100456 0.128122027291087 no 469 0.140614865998425 624 9884233 β2-adrenoceptor agonist
SGTC_2046 4110841 106 µM 1.07714616442144 0.128212805949409 no 470 0.140707485929539 732 44119630 YMR134W ERG29
SGTC_816 0325-0417 81.3 µM 1.07612924662564 0.12843554840993 no 471 0.140934728641478 703 68101
SGTC_2953 9074162 66.49 µM 1.0748997291506 0.128705216581998 no 472 0.141209811634385 666 16451992
SGTC_3271 9137798 49.47 µM 1.07348971359685 0.129014956412029 no 473 0.141525725735326 650 6498326
SGTC_2928 9011484 9.79 µM 1.07332300097954 0.129051612517336 no 474 0.141563109344039 676 2994751
SGTC_1217 1183-1422 255 µM 1.07275845079867 0.129175797190829 no 475 0.141689753666023 775 2849664
SGTC_535 2293-4129 48.2 µM 1.07241256642683 0.129251922638758 no 476 0.141767383061618 801 396118 YIL048W NEO1
SGTC_2015 5119600 184 µM 1.07218864309992 0.129301222345017 no 477 0.141817655193042 752 2828786
SGTC_1438 4092-1045 4 µM 1.07129756548258 0.129497534077824 no 478 0.142017827066983 745 1351342
SGTC_483 fpl-64176 144 µM 1.06916999258001 0.129967090727228 no 479 0.142496538725178 682 3423
SGTC_345 1362-0200 395 µM 1.06837795497644 0.130142194597484 no 480 0.142675028521647 689 1419823
SGTC_2361 9034121 116 µM 1.0661434629477 0.130637076378299 no 481 0.143179397442583 709 6496917
SGTC_1251 0490-5699 265 µM 1.06425274386373 0.131056836421106 no 482 0.143607109621629 799 3883818
SGTC_2167 5876490 200 µM 1.06349536236918 0.131225244394913 no 483 0.143778683602995 756 686534
SGTC_2610 ononetin 44.17 µM 1.06332517756395 0.131263106485557 no 484 0.143817255567406 739 259632
SGTC_3347 9188721 44.724 µM 1.06163855394989 0.131638748205589 no 485 0.144199902062084 711 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_688 0527-0193 473 µM 1.06077558653401 0.131831233353342 no 486 0.144395949798223 721 4007154
SGTC_44 0929-0055 61.211 µM 1.06017883703893 0.131964452017969 no 487 0.144531623524165 684 1379590
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.05990944486098 0.132024621674707 no 488 0.144592899196714 779 165521
SGTC_2882 9058044 58.44 µM 1.05882604387075 0.132266793991264 no 489 0.144839505191725 708 18076804
SGTC_3356 9151811 4.48 µM 1.05873782211766 0.132286527648654 no 490 0.144859598873823 732 1859254 YPR165W RHO1
SGTC_2282 7944268 200 µM 1.05833813890963 0.132375955189048 no 491 0.144950655574144 764 2970414
SGTC_1960 st011366 51.8 µM 1.05558831251348 0.132992347364667 no 492 0.14557817142653 739 3972846
SGTC_2487 5918373 44.05 µM 1.05318239499717 0.133533268274932 no 493 0.146128702758534 795 2876279
SGTC_2113 5491891 107.031 µM 1.05148181082683 0.133916521041043 no 494 0.146518679520621 759 789979
SGTC_2135 5326629 150.42 µM 1.04873773920093 0.134536532445754 no 495 0.147149419891006 686 5020077
SGTC_175 3793-3120 23.7 µM 1.0485726248 0.134573902096202 no 496 0.147187430343753 704 5322297
SGTC_3078 9116413 49.47 µM 1.04812797282635 0.134674573740821 no 497 0.147289824965332 693 17177322
SGTC_2062 5245942 200 µM 1.04687312472402 0.134958956917433 no 498 0.147579049286134 789 1376160
SGTC_1260 0700-1617 7.75 µM 1.04191879435022 0.136085766568372 no 499 0.148724664865694 772 2853078
SGTC_2051 5263410 176 µM 1.04046858504862 0.136416816124746 no 500 0.149061125950463 787 227584
SGTC_2943 9068529 45.32 µM 1.03685180861046 0.137244842027022 no 501 0.149902463064695 825 3270634
SGTC_207 4185-0010 4.486 µM 1.03048464240395 0.138710869526111 no 502 0.151391278936813 868 3761753
SGTC_2524 avocatin b 10.57 µM 1.0297121584593 0.138889455310321 no 503 0.151572573174865 719 6710748
SGTC_3139 9095020 49.47 µM 1.02967132542507 0.138898899601514 no 504 0.151582160293048 607 25236292
SGTC_96 0929-0093 37.281 µM 1.02705076271529 0.139505925427738 no 505 0.152198280825029 744 6991579
SGTC_1361 1608-0041 5.61 µM 1.02699317025527 0.139519286347819 no 506 0.152211840035606 785 X1361
SGTC_91 0417-1751 58.384 µM 1.02676702961111 0.139571757311263 no 507 0.152265088939598 883 6795624
SGTC_1895 st058434 18.3 µM 1.02607506893028 0.139732394918486 no 508 0.152428100401551 806 5393175
SGTC_781 4335-2806 94.4 µM 1.02536580633096 0.139897179539165 no 509 0.152595307992097 864 845254
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.02176464101121 0.140735883852418 no 510 0.153446154189816 749 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1718 roemerine 11.9335 µM 1.02120656028104 0.140866164477172 no 511 0.153578292434244 785 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3167 9103034 49.47 µM 1.01977978082779 0.141199609529344 no 512 0.153916457239964 727 5127859
SGTC_2761 levamisole 97.89 µM 1.01578899760194 0.14213511423689 no 513 0.154864938229933 761 26879 An alkaline phosphatase inhibitor.
SGTC_2812 7970281 58.44 µM 1.01548793402359 0.14220585822672 no 514 0.154936647654719 786 2233435
SGTC_1892 st058411 7.36 µM 1.01534265465092 0.142240004529464 no 515 0.154971259153225 849 3934738
SGTC_701 4424-0219 185 µM 1.01280784847251 0.142836675493934 no 516 0.155575975573516 866 2911779
SGTC_1173 0443-0020 122 µM 1.0113916202568 0.143170778709512 no 517 0.155914515136621 772 5331295
SGTC_1867 st057372 64 µM 1.00962948901595 0.143587220585266 no 518 0.156336417941264 781 688837
SGTC_1446 4239-0190 62 µM 1.00847676678217 0.143860083648853 no 519 0.156612817900442 831 1340085
SGTC_2612 dictamnine 15.46 µM 1.00741743270803 0.144111148875683 no 520 0.156867108713997 748 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_428 3448-4153 16.5 µM 1.00346780767618 0.145049824486937 no 521 0.157817600925114 700 3834874
SGTC_456 gingerol 170 µM 1.0033071954318 0.145088082788143 no 522 0.157856332736723 803 442793 A herb.
SGTC_504 lovastatin 124 µM 1.00132814773068 0.145560055098202 no 523 0.158334094478056 727 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_966 1300-0360 30.2 µM 1.00131289944504 0.145563695582229 no 524 0.158337779244528 787 70588
SGTC_277 nystatin 15.5 µM 1.0012182102415 0.145586303725857 no 525 0.158360662263316 828 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1824 st053723 68.6 µM 0.999590787044654 0.145975238871425 no 526 0.158754291746377 807 675225
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.998729405116652 0.1461813813964 no 527 0.158962896016041 816 2724 A muscle relaxant with antifungal properties.
SGTC_1741 st038134 10.228 µM 0.996712616797918 0.146664795710712 no 528 0.159452011899578 863 1272587
SGTC_636 0kpi-0074 126 µM 0.996694318832464 0.146669186548546 no 529 0.159456454067117 767 616434
SGTC_1539 benzyladenosine 56 µM 0.996694211213308 0.146669212373441 no 530 0.159456480193886 776 92208 A nucleotide analog.
SGTC_399 oxolinic acid 75 µM 0.996523255514081 0.146710239712043 no 531 0.159497986751816 782 4628 A DNA gyrase inhibitor.
SGTC_217 ketoconazole 989 nM 0.994313368413298 0.147241279506518 no 532 0.160035164673338 798 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3238 9133470 49.47 µM 0.990561522939376 0.148145801864788 no 533 0.160949866866602 800 3534688
SGTC_1611 st001856 99.4 µM 0.989519799079819 0.148397606394336 no 534 0.161204443877698 787 647478
SGTC_657 3534-0529 86.7 µM 0.983641363059981 0.149823899523561 no 535 0.162645940003458 838 1049549
SGTC_1988 st071872 53.4 µM 0.981554057404019 0.150332537953874 no 536 0.163159795290917 854 16414116
SGTC_1105 epirubicin 18.1 µM 0.980660500753378 0.150550632777247 no 537 0.163380094233671 793 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3344 9148862 3.898 µM 0.979806256898508 0.150759329277432 no 538 0.163590881503386 843 4905352
SGTC_412 gemfibrozil 100 µM 0.979751150092739 0.150772798785414 no 539 0.163604485335662 776 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1403 3909-7815 62.9 µM 0.979413631090925 0.150855314514346 no 540 0.163687822320561 790 6615483
SGTC_127 0180-0333 59.125 µM 0.979132358820314 0.15092410215579 no 541 0.163757292445428 880 771601
SGTC_1997 st073024 93.8 µM 0.978243214809785 0.15114168754077 no 542 0.16397702382258 828 686268
SGTC_1076 itraconazole 331 nM 0.976886724257856 0.151474040739982 no 543 0.164312617453292 851 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.976650597910279 0.151531943577368 no 544 0.164371080214494 861 16623 A steroid.
SGTC_2 0422-0095 29 µM 0.976586052801193 0.15154777387171 no 545 0.164387063349994 702 6790840
SGTC_1388 3346-4487 254 µM 0.976174111236223 0.151648832309202 no 546 0.164489095089946 874 3345614
SGTC_1486 3970-0793 4.53 µM 0.973666958977244 0.152264858294376 no 547 0.165110963965052 850 2844330
SGTC_1114 scopoletin 1.73284 µM 0.9732801688324 0.152360043225336 no 548 0.165207037929828 823 5280460 A coumarin with genotoxic properties.
SGTC_305 1682-2595 20.8 µM 0.97272045491279 0.152497852767788 no 549 0.165346128104022 855 226033
SGTC_2939 9044578 71.43 µM 0.970797778903068 0.152971872901872 no 550 0.165824494432854 790 2653634
SGTC_150 3970-0969 77.2 µM 0.968522144871306 0.15353417295048 no 551 0.166391832418583 869 6615640
SGTC_3142 9086498 49.47 µM 0.968162035104998 0.153623279916359 no 552 0.166481726055214 777 25236367
SGTC_2125 5246583 200 µM 0.967287035987509 0.153839935771796 no 553 0.166700281329519 918 835267
SGTC_2020 4017018 200 µM 0.964102258199631 0.154630215706021 no 554 0.167497330331413 816 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_544 k015-0020 52.4 µM 0.96282228179808 0.154948587207343 no 555 0.167818358415766 821 3008304
SGTC_1915 st067105 30.6 µM 0.962083058776756 0.155132652936514 no 556 0.168003941663691 824 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1269 0831-0796 3.05 µM 0.962062247717941 0.155137836955908 no 557 0.168009168227732 848 927758
SGTC_564 3555-0129 330 µM 0.96077144406984 0.155459598731201 no 558 0.168333549818529 757 563260
SGTC_764 1951-2361 146 µM 0.960191285185703 0.15560435967202 no 559 0.168479476052025 805 5438930
SGTC_3269 9137823 49.47 µM 0.95792965364118 0.156169529432142 no 560 0.169049116125803 770 17682936
SGTC_2964 9083345 53.42 µM 0.957592123384665 0.156253992300333 no 561 0.169134236265081 791 17741579
SGTC_1757 st041620 31.8375 µM 0.955846173952164 0.15669137539697 no 562 0.169574978174798 850 5289815
SGTC_637 1181-0519 7.26 µM 0.955509802796357 0.156775733249962 no 563 0.169659975215307 919 6252091 YGR060W ERG25
SGTC_485 niflumic acid 177 µM 0.95547816869866 0.156783668239683 no 564 0.169667970185902 812 4488 A COX2 inhibitor.
SGTC_663 1486-0733 13.9 µM 0.955246625413087 0.156841755818649 no 565 0.169726496100838 870 722445 YPR165W RHO1
SGTC_1906 st060206 94.7 µM 0.953416761746012 0.157301314327304 no 566 0.170189476031967 908 5133468
SGTC_3306 9127676 59.7925 µM 0.952788454136732 0.157459313707344 no 567 0.170348632699085 813 41905287
SGTC_3235 9132602 49.47 µM 0.949933381434333 0.158178587046569 no 568 0.17107305189399 872 4912240
SGTC_179 1273-0063 6.77 µM 0.94935641643417 0.158324202303289 no 569 0.171219684525697 806 3108139
SGTC_1855 st056195 39.6 µM 0.947399162623058 0.158818831871372 no 570 0.171717708834091 818 4028379
SGTC_197 4544-0043 41.561 µM 0.946982147472814 0.158924349071909 no 571 0.171823938026258 882 896523
SGTC_582 0987-0078 156 µM 0.942795682982667 0.159986193846361 no 572 0.172892710146222 972 1625765
SGTC_1307 1187-1599 12.2 µM 0.941990353870371 0.160190986462601 no 573 0.173098789270237 852 1538471
SGTC_788 1182-0090 188 µM 0.941541858241153 0.160305111725519 no 574 0.173213624544376 971 5715185
SGTC_2665 lovastatin 100 µM 0.940466894290349 0.160578865865987 no 575 0.173489061633001 844 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_958 1222-0007 33 µM 0.939846251861457 0.160737059840754 no 576 0.173648215172133 917 7312461
SGTC_1677 st019204 53.9 µM 0.935008223869479 0.161973699790528 no 577 0.174892030624899 805 3945625
SGTC_1063 disulfiram 1.84 µM 0.934944739578808 0.161989967987331 no 578 0.174908389383372 861 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1693 xanthone 101.9 µM 0.934794723335317 0.162028414699373 no 579 0.174947049726043 898 7020 An insecticide.
SGTC_2772 vinpocetine 57.06 µM 0.93140071695358 0.162899831205841 no 580 0.175823160075887 849 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1621 st003705 32.4 µM 0.931376094468504 0.162906164181123 no 581 0.175829526126877 923 24207032
SGTC_914 3820-6779 408 µM 0.931155726782186 0.162962850523008 no 582 0.17588650786434 860 2893481
SGTC_2066 5222451 176 µM 0.928418406399844 0.163668054691758 no 583 0.176595287159757 939 2281147
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.927671820562193 0.163860737774137 no 584 0.176788915043955 947 1273210
SGTC_3012 9080433 71.4286 µM 0.924152442354866 0.164771020455401 no 585 0.177703476221549 936 17688859
SGTC_2178 5812956 200 µM 0.923971394032687 0.164817936797245 no 586 0.177750604830308 886 5403383
SGTC_2779 methotrexate 400 µM 0.923462159726022 0.164949944703417 no 587 0.177883205663513 943 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3002 9075603 71.4286 µM 0.923223588841552 0.165011812555388 no 588 0.177945349205994 920 20105405
SGTC_2987 9018338 71.43 µM 0.923019194091872 0.165064829564355 no 589 0.17799860135104 898 5055682
SGTC_519 k048-0011 62.8 µM 0.92153947890877 0.165448974904605 no 590 0.178384419742493 871 6836379
SGTC_3007 9078383 71.4286 µM 0.918746475079812 0.166175634703351 no 591 0.179114097351251 883 6496995
SGTC_3062 9077494 49.47 µM 0.918320437255557 0.166286658523457 no 592 0.17922556537221 863 16459633
SGTC_480 am 92016 50 µM 0.915558474617769 0.167007576995348 no 593 0.179949259798319 824 2129 K+ channel blocker.
SGTC_2539 epi(13)torulosol 80 µM 0.915312970909068 0.167071754970571 no 594 0.180013675810527 865 6708597
SGTC_2238 6671620 73.2395 µM 0.914050910158448 0.167401925605407 no 595 0.180345047644415 908 729941
SGTC_2777 climbazole 1.536 µM 0.913915038874745 0.167437496258684 no 596 0.180380745371585 919 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2541 muurolladie-3-one 83.07 µM 0.912456722600493 0.167819585256089 no 597 0.180764170756371 854 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_329 k048-0121 21.3 µM 0.912099365825989 0.167913300783561 no 598 0.180858206080664 869 6832902
SGTC_1422 4031-0024 15.5 µM 0.910452048491318 0.168345739294934 no 599 0.181292079628135 887 782427
SGTC_1412 3909-8563 178 µM 0.909905000856358 0.168489503466593 no 600 0.181436306112763 1000 23767530
SGTC_2968 9090663 33.37 µM 0.909430416894774 0.168614288104702 no 601 0.181561486068109 871 25236811
SGTC_451 chloral hydrate 100 µM 0.906930175088799 0.169272669241763 no 602 0.182221861444014 958 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1246 0422-0085 105 µM 0.906654308115251 0.169345413414848 no 603 0.182294816541659 934 264295
SGTC_137 0438-0332 85.389 µM 0.906422482750397 0.169406559640269 no 604 0.182356138616255 982 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1699 st031318 29.054 µM 0.906387477024218 0.169415793976824 no 605 0.182365399394846 950 5340658
SGTC_1829 berberine 14.4 µM 0.906060990575925 0.169501935034984 no 606 0.182451785662751 896 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1072 oxiconazole 14.9 nM 0.905544740866809 0.16963820108192 no 607 0.182588434257651 908 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3024 9090631 49.47 µM 0.90527280620197 0.169710007505438 no 608 0.182660439633248 873 25236383
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.904629263171216 0.16988001759894 no 609 0.182830913527266 983 91467 include heat shock
SGTC_1085 doxorubicin 7.67 µM 0.903980996216159 0.170051386012518 no 610 0.183002739153054 978 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_177 1327-0068 8.361 µM 0.901606880821351 0.170679925424275 no 611 0.183632867269019 920 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_849 0386-0493 241 µM 0.89996930926367 0.171114332736336 no 612 0.184068291811789 886 726119
SGTC_2749 bexarotene 57.39 µM 0.898023669286031 0.171631381305659 no 613 0.184586465417337 873 82146 An retinoic acid receptor inhibitor.
SGTC_1850 st056238 17 µM 0.897249915505584 0.171837281398156 no 614 0.184792787667209 991 5393177
SGTC_2575 plumbagin 510 nM 0.896800091641272 0.171957054455096 no 615 0.184912799534278 879 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1425 4048-4433 7.33 µM 0.895328371772248 0.172349296616092 no 616 0.185305789024921 958 23734946
SGTC_2117 5521686 200 µM 0.895161124280288 0.17239390743709 no 617 0.185350481475222 885 803312
SGTC_3270 9137563 49.47 µM 0.893895222072733 0.172731807159555 no 618 0.185688977206527 875 17015724
SGTC_2201 6605497 169.863 µM 0.893640794991844 0.17279977078054 no 619 0.185757055955996 920 670741
SGTC_1836 st055642 81 µM 0.892866850834457 0.173006614725195 no 620 0.185964240515655 950 8571
SGTC_54 0159-0055 9 µM 0.892320466002532 0.173152736221751 no 621 0.186110593776289 916 3319099
SGTC_613 3914-0030 117 µM 0.892184186073401 0.173189194256273 no 622 0.18614710849504 708 1145395
SGTC_830 4076-0286 57.8 µM 0.889434851652944 0.173925748789245 no 623 0.18688471075396 1020 6866659
SGTC_2652 actinonin 100 µM 0.889097764305377 0.174016192335565 no 624 0.18697527017949 901 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2303 7774051 200 µM 0.888668868560456 0.174131312112549 no 625 0.187090533420027 889 2953184
SGTC_1853 st056710 91.2 µM 0.886198156796455 0.174795417405878 no 626 0.187755378362808 990 269167
SGTC_3186 9110464 49.47 µM 0.883638930863728 0.175485007252558 no 627 0.188445578158543 907 17018021
SGTC_2453 5731132 22.18 µM 0.882816753236793 0.175706910553364 no 628 0.1886676436207 971 1362040
SGTC_1061 3448-9325 110 µM 0.882816019065067 0.175707108783544 no 629 0.188667841988333 919 723482
SGTC_2941 9056145 11.23 µM 0.880253622686669 0.176399832235209 no 630 0.189360965194828 850 2119517
SGTC_518 1021-0119 62.6 µM 0.879891367470882 0.176497904260031 no 631 0.18945908082145 857 1097762
SGTC_651 3253-0966 34.4 µM 0.878515958590054 0.176870577630208 no 632 0.189831890573772 946 781462
SGTC_2745 rifampicin 24.3 µM 0.878343879230037 0.176917238304233 no 633 0.189878565059497 813 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_700 3453-2283 142 µM 0.878065981987782 0.176992608754786 no 634 0.18995395628753 991 565664
SGTC_745 0469-0705 296 µM 0.877809736304554 0.177062124911495 no 635 0.190023489930592 1024 3486736
SGTC_3129 9127257 49.47 µM 0.877791832406514 0.177066982653299 no 636 0.190028348834189 799 837894
SGTC_1210 3013-0140 750 nM 0.877598142465083 0.177119540598513 no 637 0.190080918847152 996 905973
SGTC_900 1112-0045 141 µM 0.876637063248919 0.177380476081115 no 638 0.190341900641084 835 56211 YIL048W NEO1
SGTC_760 0568-0725 82.9 µM 0.876274295547959 0.177479031509136 no 639 0.190440467675949 989 3916171
SGTC_1447 4239-0816 81.9 µM 0.876236297486218 0.177489356685806 no 640 0.190450793882054 874 1341554
SGTC_1985 st071382 65.5 µM 0.875143877987619 0.177786360914396 no 641 0.190747812590756 984 6123237
SGTC_3113 9123498 49.47 µM 0.871585685285181 0.178755925309329 no 642 0.191717221339067 1002 8897275
SGTC_718 1130-0073 349 µM 0.870176881380801 0.179140725469833 no 643 0.192101873970346 952 6740020
SGTC_594 1487-1584 10.8 µM 0.86804988645052 0.179722678450331 no 644 0.19268351171107 964 5013332
SGTC_1793 st048256 72.231 µM 0.86592551930369 0.180305096613103 no 645 0.193265503771274 931 672022
SGTC_1029 k015-0030 64.7 µM 0.863827729804848 0.180881389077111 no 646 0.193841266175226 921 2208316
SGTC_9 0092-0002 10.449 µM 0.863765980377063 0.180898369991388 no 647 0.193858229839691 945 759368
SGTC_284 0988-0104 32.6 µM 0.863589113960219 0.180947013274089 no 648 0.193906823192801 990 4666532
SGTC_1863 st057641 20.1 µM 0.863481863455908 0.18097651419764 no 649 0.193936293462741 1010 3921635
SGTC_298 1391-0729 10 µM 0.862413781417074 0.181270471259939 no 650 0.194229929729793 942 3237558
SGTC_2923 7992654 58.14 µM 0.861955790951181 0.181396610736898 no 651 0.194355923004333 933 2985126
SGTC_2601 securinine 100 µM 0.861423284608711 0.181543342410151 no 652 0.194502478159333 905 442872 A GABA receptor antagonist.
SGTC_1480 1070-0044 41.2 µM 0.860810389529346 0.181712317059094 no 653 0.194671240949628 974 3124987
SGTC_2420 aureobasidin a 50 nM 0.859126444438034 0.182177085659745 no 654 0.195135379535963 986 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1708 st033234 31.827 µM 0.856929481145297 0.18278456315216 no 655 0.195741929305719 1027 674664
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.856430431949555 0.182922730192289 no 656 0.195879868900398 993 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2974 9094440 9.66 µM 0.855934398790199 0.183060126780517 no 657 0.196017033282771 974 25236134
SGTC_1048 3161-0300 24.5 µM 0.855930677772919 0.183061157711066 no 658 0.196018062448297 1008 2165101
SGTC_560 2332-1943 155 µM 0.855250643286053 0.183249626233079 no 659 0.196206202621153 951 21177716
SGTC_1185 1319-0113 81.3 µM 0.855098275632728 0.183291870835876 no 660 0.196248372076865 934 4672763
SGTC_490 phenamil 164 µM 0.854439767936649 0.18347451482304 no 661 0.196430684646582 889 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_802 4112-3352 742 µM 0.854109945196376 0.183566037230108 no 662 0.196522037001334 1009 704594
SGTC_141 0443-0274 32.331 µM 0.853732903701046 0.183670697201598 no 663 0.196626499256774 1106 1627241
SGTC_996 3970-0799 1.8 µM 0.853590942039644 0.183710112851112 no 664 0.196665839545741 1130 6615648 YGL040C HEM2
SGTC_2626 ethyl orsellinate 100 µM 0.853135564410716 0.183836583992542 no 665 0.196792065560991 944 75653 A natural product.
SGTC_283 0987-0079 11.7 µM 0.849731508441168 0.184783702851256 no 666 0.197737188234553 1007 411556
SGTC_2713 st079149 53.4 µM 0.848817561359428 0.185038508187091 no 667 0.197991408356007 964 3103253
SGTC_3234 9132280 49.47 µM 0.847401284954824 0.185433792211704 no 668 0.198385744263319 960 17612295
SGTC_2184 6075246 200 µM 0.847278517279183 0.185468081450874 no 669 0.19841994895321 947 2267320
SGTC_2247 cerulenin 830 nM 0.847239770498144 0.185478904315586 no 670 0.198430745054969 971 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.846664070137225 0.185639756809818 no 671 0.198591195477959 931 689007
SGTC_1946 st076057 65.1 µM 0.845055493047284 0.186089656910485 no 672 0.199039928149092 873 953009
SGTC_133 0724-0033 378.92 µM 0.844024317433589 0.186378419800208 no 673 0.199327908551663 932 280309
SGTC_1508 1080-0625 72.9 µM 0.840299738556425 0.187423733844052 no 674 0.20037017399019 932 767111
SGTC_2082 5219693 150 µM 0.839925718551006 0.187528903507428 no 675 0.200475018254612 1010 2834649
SGTC_1626 st003712 1.76 µM 0.839172561375549 0.187740792344568 no 676 0.200686241164115 916 24207035
SGTC_2696 st077691 74.316 µM 0.838492448878865 0.18793225822741 no 677 0.20087709343846 906 757133
SGTC_495 decylubiquinone 155 µM 0.836163574523302 0.188588797785078 no 678 0.201531443597981 920 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2850 9015429 58.44 µM 0.836032396435875 0.188625820592589 no 679 0.201568339016794 970 6457570
SGTC_871 0574-0004 149 µM 0.83592508202717 0.188656111610397 no 680 0.201598525497498 966 9551173
SGTC_3289 9119912 71.43 µM 0.834197971246711 0.189144025586407 no 681 0.202084717092598 976 17014829
SGTC_2780 5215298 71.43 µM 0.833069813901714 0.189463152601278 no 682 0.202402678377498 1025 2834131
SGTC_2455 5377712 9.75 µM 0.83252326279517 0.189617877082097 no 683 0.202556826541712 895 2243908
SGTC_1878 temozolomide 1 mM 0.832320955410693 0.18967516847689 no 684 0.2026139026967 984 5394 DNA alkylating agent.
SGTC_3231 9132313 49.47 µM 0.831204356338228 0.189991569506103 no 685 0.202929097129417 984 4905967
SGTC_3299 9121982 43.1275 µM 0.829966762190003 0.190342634679827 no 686 0.203278788103157 1000 17594604 YPL160W CDC60
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.829867930061495 0.190370687306837 no 687 0.203306729317214 1050 676296 Flavone; oxidizing agent.
SGTC_2856 9022925 19.48 µM 0.829200368217744 0.190560235334438 no 688 0.203495518327637 981 4944862
SGTC_3276 9139060 49.47 µM 0.829128783282093 0.190580568092788 no 689 0.203515769023889 1000 4870619
SGTC_3137 9097352 49.47 µM 0.828215989629663 0.190839951862373 no 690 0.203774095020082 1050 44120435
SGTC_1783 st039459 87.517 µM 0.828017591004926 0.190896358398153 no 691 0.20383026885177 1056 729761
SGTC_35 0133-0054 64.071 µM 0.826261189429674 0.191396165316964 no 692 0.204327972131853 966 99677
SGTC_1810 st050138 53 µM 0.825664611895852 0.19156611149855 no 693 0.204497185985268 992 3444541
SGTC_983 1491-0821 12.2 µM 0.823737726491379 0.192115651720305 no 694 0.205044299118722 1010 46495113
SGTC_3281 9140613 49.47 µM 0.823395979464979 0.192213217250896 no 695 0.205141424337287 957 16013766
SGTC_1791 st048313 56.1 µM 0.820750642605297 0.192969460708959 no 696 0.205894159006853 966 1204976
SGTC_36 0335-0881 14.2 µM 0.819990320633767 0.193187155722506 no 697 0.206110812568066 1020 23828853
SGTC_673 1082-0474 110 µM 0.819659519461908 0.193281917333127 no 698 0.20620511646571 1103 3098046
SGTC_2571 chrysanthemic acid 100 µM 0.818111149806566 0.193725841756626 no 699 0.206646861406876 952 2743 An insecticide.
SGTC_1942 st076330 65.2 µM 0.815267120116941 0.19454285551423 no 700 0.207459712563203 1067 24208414
SGTC_2851 9015922 71.43 µM 0.81267699931477 0.195288749607311 no 701 0.208201635894577 999 2996893
SGTC_266 formosanin C 406 nM 0.812191126187678 0.195428862982729 no 702 0.208340985294094 1023 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2996 9066192 71.4286 µM 0.812053722467945 0.195468497771856 no 703 0.208380402936867 1032 6472854
SGTC_1608 st001473 40.5 µM 0.811256080133122 0.195698678103344 no 704 0.20860931316581 971 7292267
SGTC_1770 st043884 66.3 µM 0.810971805482963 0.195780752662607 no 705 0.208690931131083 1066 670149
SGTC_1981 st071826 47 µM 0.809352618825923 0.196248635559736 no 706 0.209156173858039 970 11838600
SGTC_1261 0712-0010 12.7 µM 0.807454173642607 0.196798076042433 no 707 0.209702433225436 1056 2840123
SGTC_2485 5633444 17.78 µM 0.80540518756105 0.197392129555747 no 708 0.210292949588731 997 5724239
SGTC_201 4262-0159 12.803 µM 0.804084882741702 0.197775493620118 no 709 0.210673977285748 996 1341029
SGTC_1169 aniline yellow 25.8 µM 0.803882060557415 0.197834424962671 no 710 0.210732545750676 1002 6051 A DNA damaging agent.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.803002974025464 0.198089972053183 no 711 0.210986507802237 1080 6728940
SGTC_413 propylparaben 100 µM 0.798952087821091 0.1992701223328 no 712 0.212159097116061 999 7175 A pharmaceutical preservative.
SGTC_2460 5552655 174.22 µM 0.798752611790186 0.199328345137353 no 713 0.2122169366784 1051 5401989
SGTC_919 tnp00227 403.569 nM 0.797204279485795 0.199780618593334 no 714 0.212666200516874 1049 1269246 A methoxyflavone. YNL221C POP1
SGTC_291 SEC14.278 35.5 µM 0.797088012885778 0.199814605386052 no 715 0.212699958816689 1065 1068044
SGTC_1128 3448-9350 235 µM 0.796952724468559 0.199854156971299 no 716 0.212739244087333 941 619386
SGTC_75 0159-0059 199.013 µM 0.795071581531253 0.200404597112506 no 717 0.213285932251127 1014 5377270
SGTC_2380 9035439 200 µM 0.792590883302778 0.201131863436148 no 718 0.214008111014148 1098 6462575
SGTC_2883 9059145 45.46 µM 0.792125198717103 0.201268564428867 no 719 0.214143839217465 1054 16476510
SGTC_1136 pergolide 1.05886 µM 0.789215053844276 0.202124093922952 no 720 0.214993162465541 1009 47811 A dopamine receptor agonist.
SGTC_191 3914-0123 66.505 µM 0.787715118824078 0.202565895956781 no 721 0.215431680045191 944 3144412
SGTC_322 k048-0136 19.3 µM 0.787606832506844 0.202597813741018 no 722 0.215463358454833 1029 6823282
SGTC_80 0159-0065 512.242 µM 0.78646355083845 0.202934983529177 no 723 0.215797982387461 1003 1548079
SGTC_163 TUB2.036 7.546 µM 0.786337357393839 0.202972220271299 no 724 0.215834936045188 1124 15992207 YJR013W GPI14
SGTC_3216 9129716 49.47 µM 0.785321000512097 0.203272272228397 no 725 0.216132692989057 1018 8056934
SGTC_31 0508-1974 57.237 µM 0.78524232148694 0.203295511122836 no 726 0.216155753102323 1039 6810525
SGTC_2826 7992541 19.48 µM 0.783095458522906 0.203930227261659 no 727 0.216785528936903 1121 2985066
SGTC_3346 9158254 43.5805 µM 0.782947103486904 0.203974131736519 no 728 0.216829087599546 1026 17639500
SGTC_1247 0448-0043 5.84 µM 0.780740096911947 0.204627942385038 no 729 0.217477686219219 1081 3089013 YGL099W LSG1
SGTC_2336 9001819 198.65 µM 0.780414713541326 0.204724440343422 no 730 0.217573405046495 1086 2989602
SGTC_3348 9149464 3.537 µM 0.776897767978416 0.205769176561245 no 731 0.218609544112431 1093 1951442
SGTC_3230 9131665 49.47 µM 0.77662477623799 0.205850402996309 no 732 0.218690089751483 1025 15943720
SGTC_2309 7664088 163.95 µM 0.775343996553161 0.206231742312835 no 733 0.219068209089895 1091 704922
SGTC_2351 9026858 72.31 µM 0.773831624772441 0.206682574607173 no 734 0.219515184107352 1044 1409300
SGTC_3023 9089636 49.47 µM 0.772614084271224 0.20704594248101 no 735 0.219875403320258 1183 17249241
SGTC_2606 farnesol 9.78 µM 0.772588883377982 0.207053467531303 no 736 0.219882862790365 1084 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2375 9072683 200 µM 0.768047100891258 0.208412295944682 no 737 0.221229601320757 1168 16798029
SGTC_3044 9093193 49.47 µM 0.767885994095997 0.208460592905 no 738 0.221277459528172 1090 25236277
SGTC_526 4469-0568 170 µM 0.767481608007714 0.208581849754936 no 739 0.2213976120968 1085 2901964
SGTC_2157 5649910 96.377 µM 0.766679752830153 0.208822412302743 no 740 0.221635972323173 1074 2858091
SGTC_1434 4073-0095 163 µM 0.765308470055424 0.209234186010956 no 741 0.222043940779173 1126 24133745
SGTC_522 1273-0010 11.6 µM 0.764859267073686 0.209369178154629 no 742 0.222177675703093 1104 5705015
SGTC_2092 5303694 80.6725 µM 0.764635004421802 0.209436591576692 no 743 0.222244459486861 1067 1963699
SGTC_353 1988-1175 58.3 µM 0.762082981012664 0.210204629749219 no 744 0.223005239846095 998 2788357
SGTC_2101 5377231 179.231 µM 0.7557347485912 0.212122307437561 no 745 0.224904122882111 1093 2844213
SGTC_1180 1193-0155 285 µM 0.75407461018943 0.212625485139929 no 746 0.225402211063472 1093 2921347
SGTC_1545 lovastatin 49.4 µM 0.754026864343288 0.212639966915506 no 747 0.225416545392346 1153 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2971 9092186 9.93 µM 0.753855691659464 0.212691889975062 no 748 0.225467939351265 1052 25236400
SGTC_2322 7413319 38.22 µM 0.752510987157816 0.213100046447818 no 749 0.225871912506911 1119 1840400
SGTC_2119 5528445 120.635 µM 0.751918098119659 0.213280150351226 no 750 0.226050156857204 1097 791935
SGTC_2627 acetyl isogambogic acid 100 µM 0.751736917685119 0.213335205843548 no 751 0.226104642246315 1090 6857789 A caspase activator and apoptosis inducer.
SGTC_2083 5306046 65.942 µM 0.748091388652212 0.214444736063762 no 752 0.227202517912633 1130 539837
SGTC_1529 apigenin 74 µM 0.746158149715971 0.215034483402895 no 753 0.22778594283064 1135 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2400 5203494 178.7 µM 0.746003672075559 0.215081648427643 no 754 0.227832598407508 1086 6777674
SGTC_2653 dihydrofissinolide 100 µM 0.744556157373582 0.215523894524613 no 755 0.228270040229451 1131 6857746
SGTC_2840 9008771 71.43 µM 0.743702807426076 0.215784857743864 no 756 0.228528145319644 1098 2992978
SGTC_2505 galangin 7.89 µM 0.742226581339202 0.216236735111342 no 757 0.228975033016856 1026 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1026 k007-1105 30.6 µM 0.741375872307527 0.216497388422348 no 758 0.229232784810019 1112 7066794
SGTC_1337 1486-1011 40.3 µM 0.740759329032915 0.216686408000254 no 759 0.229419689606863 1159 X1337
SGTC_420 mitomycin C 81.9 mM 0.739280174593027 0.217140275522803 no 760 0.229868442635176 1112 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2093 5331342 194.4 µM 0.738409334028919 0.217407743127179 no 761 0.230132872109443 1144 33839
SGTC_3028 9087778 49.47 µM 0.737184228845354 0.217784340446168 no 762 0.23050516146014 1116 17217395
SGTC_2823 7987624 58.44 µM 0.737098982450248 0.21781055918251 no 763 0.2305310789603 1126 2239440
SGTC_1856 st057054 55.7 µM 0.735489858474516 0.218305809483338 no 764 0.231020607065293 1159 1266018
SGTC_2311 7694451 200 µM 0.734328235478245 0.218663732418987 no 765 0.231374356633455 1086 2163142
SGTC_1242 0402-0103 60.1 µM 0.733622801406946 0.218881257738292 no 766 0.231589330128939 1114 432868
SGTC_1633 st005664 67.9 µM 0.732623948082429 0.219189473681961 no 767 0.231893910334046 1173 2063822
SGTC_1994 st072947 40.9 µM 0.728216039418486 0.220552597426023 no 768 0.233240674440037 1131 5286565 YDL195W SEC31
SGTC_167 3672-0051 66.205 µM 0.726590897326987 0.221056387399818 no 769 0.233738303054111 1116 3237971
SGTC_1772 st048439 82.2 µM 0.726006547691909 0.221237695163331 no 770 0.233917378291261 1133 2927068 YDL195W SEC31
SGTC_465 cgp-37157 41 µM 0.725615400714114 0.221359104919158 no 771 0.234037288604093 1054 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1419 3993-2473 62.6 µM 0.725549823096848 0.221379463560275 no 772 0.234057395459881 1174 704026
SGTC_1340 1486-1359 257 µM 0.723994455379444 0.221862642870663 no 773 0.234534569535591 1135 4309068
SGTC_1212 0520-0165 585 µM 0.720967435448749 0.222804719702105 no 774 0.235464775305237 1202 5403258
SGTC_3203 9113543 49.47 µM 0.718716612195943 0.223506701770505 no 775 0.236157772820613 1151 17018012
SGTC_2685 mycophenolic acid 18.85 µM 0.718144979949284 0.223685181365938 no 776 0.236333949246899 1131 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1379 2144-0755 36.5 µM 0.717415964501518 0.223912917933688 no 777 0.236558735951951 1200 5392327
SGTC_2198 6589944 200 µM 0.717127089401505 0.224003195836888 no 778 0.236647841059643 1099 5290268
SGTC_2358 9037157 4 µM 0.71671415361608 0.224132280509037 no 779 0.236775245420502 1156 2388925
SGTC_803 4488-1585 147 µM 0.713894230029958 0.225014923629983 no 780 0.237646292761654 1153 747204
SGTC_1057 3448-5381 134 µM 0.713526484304977 0.225130173973909 no 781 0.237760015340272 1184 5497911
SGTC_3352 9151559 45.5865 µM 0.711526453920123 0.225757562375485 no 782 0.238379031916892 1149 17159339
SGTC_1196 1588-0294 184 µM 0.711060502019876 0.225903868479092 no 783 0.238523372355575 1146 6144269
SGTC_1759 st043059 70 µM 0.710717371522233 0.22601164366786 no 784 0.23862969632608 1181 669426
SGTC_2667 digitoxin 100 µM 0.710302507304157 0.226141988786891 no 785 0.238758282662512 1146 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_193 1273-0060 1.558 µM 0.709924198342329 0.226260885726409 no 786 0.238875571806002 1059 2847393 YHR072W ERG7
SGTC_2994 9053520 71.4286 µM 0.709919453864671 0.226262377070112 no 787 0.238877042961743 1157 4647384
SGTC_2212 7123476 200 µM 0.705903459286582 0.227526725002981 no 788 0.240124088081506 1140 1085715
SGTC_2924 9010168 62.78 µM 0.705857077108957 0.227541350619629 no 789 0.24013851135725 1200 2993929
SGTC_994 3910-0338 138 µM 0.705377422427913 0.227692630393665 no 790 0.240287695297202 1231 3479481
SGTC_993 3909-8757 62.7 µM 0.70500133433248 0.22781128557102 no 791 0.240404702892112 1122 4288324 YLR208W SEC13
SGTC_2387 9077560 195.08 µM 0.703930684834681 0.228149264193673 no 792 0.24073797057314 1175 5303272
SGTC_2174 5790901 200 µM 0.70239274926574 0.228635246930312 no 793 0.241217132922169 1189 786020
SGTC_24 0417-1663 219 µM 0.701029469942441 0.229066524480735 no 794 0.241642312038461 1173 4329390
SGTC_2650 prasterone 100 µM 0.70064252956123 0.229189017339984 no 795 0.241763064966594 1142 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2753 fluvastatin 17.09 µM 0.70025723819281 0.229311024665641 no 796 0.241883335817815 1179 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_464 bw-b 70c 158 µM 0.698419480040462 0.229893474520919 no 797 0.24245744870062 1210 5353454
SGTC_118 0083-0097 135.343 µM 0.698172782161064 0.229971724709259 no 798 0.242534572903733 1269 5207356
SGTC_2843 9000894 45.46 µM 0.69750490191727 0.230183644671592 no 799 0.242743436379858 1070 2242070
SGTC_1516 st013856 110 µM 0.697094370851932 0.230313961329364 no 800 0.242871868391828 1164 5281404 A mutagen and neurotoxin.
SGTC_1342 1486-1464 234 µM 0.695310607039868 0.230880668028164 no 801 0.243430334178718 1226 3253938
SGTC_811 0416-0114 265 µM 0.694773882270543 0.231051339239618 no 802 0.243598509166109 1214 6612453
SGTC_3100 9120536 49.47 µM 0.694579207414421 0.231113260606856 no 803 0.243659523235138 1102 16421196
SGTC_2545 solidagenone 89.61 µM 0.694008620619133 0.231294803816934 no 804 0.243838401365313 1037 6708572 An anti ulcer agent
SGTC_3318 9139014 38.6185 µM 0.693089520905716 0.231587400334706 no 805 0.244126686750506 1176 16643984
SGTC_1098 clofazimine 15.1 µM 0.691954260770365 0.231949096415413 no 806 0.244483026722264 1224 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_852 0418-0143 439 µM 0.690520677199611 0.232406288011458 no 807 0.244933405692684 1237 5369229
SGTC_3107 9121808 49.47 µM 0.690268242974292 0.232486844993341 no 808 0.245012757397471 1156 662681
SGTC_2300 7976697 71.57 µM 0.688337866540393 0.233103381146592 no 809 0.245620020619344 1133 2236109
SGTC_1505 k297-0037 20.6 µM 0.687886369345176 0.233247714130481 no 810 0.245762170426232 1206 4089396
SGTC_1452 4194-0072 190 µM 0.687772814716274 0.233284022666468 no 811 0.245797929023588 1245 1343545
SGTC_2546 rhodinyl acetate 100 µM 0.687481500553843 0.23337718328524 no 812 0.245889677253275 1192 6708682
SGTC_2384 9036245 200 µM 0.687466017314931 0.23338213531495 no 813 0.245894554151755 1206 6462766
SGTC_2235 salicylic acid 500 µM 0.686833013280864 0.233584639939257 no 814 0.246093981704223 1219 338 A COX inhibitor and kinase inhibitor.
SGTC_1499 4480-0877 67.3 µM 0.686817491380253 0.233589606781548 no 815 0.246098872959496 1142 2861909
SGTC_2671 danthron 100 µM 0.681846886199212 0.235183156108031 no 816 0.247667886724223 1190 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1294 1000-1494 117 µM 0.680818752838524 0.235513517850411 no 817 0.247993091285492 1201 712797 YDL207W GLE1
SGTC_1522 st012842 45.6 µM 0.67853529814027 0.236248156802673 no 818 0.248716175514078 1150 3491067 YOR116C RPO31
SGTC_1468 k284-1086 134 µM 0.677331065539225 0.236636093301472 no 819 0.249097962388316 1246 15996457
SGTC_1957 st077035 62.4 µM 0.676990435223123 0.236745888918585 no 820 0.24920601150366 1284 705593
SGTC_2269 7935389 174.42 µM 0.676751239662102 0.236823005739644 no 821 0.249281900057294 1193 97605
SGTC_1013 4112-3890 241 µM 0.675452289782268 0.237242029194503 no 822 0.249694226784707 1178 705171
SGTC_1198 1612-1005 86.7 µM 0.671085982830164 0.238653520581828 no 823 0.25108287800137 1291 6998509
SGTC_1417 3966-0327 90.4 µM 0.671060646075721 0.238661724556236 no 824 0.251090947955969 1279 651118
SGTC_632 0781-2353 4.65 µM 0.66998884988087 0.239008910650149 no 825 0.25143244906565 1269 6811515 YHR007C ERG11
SGTC_1661 st013063 9.66 µM 0.669531499158374 0.239157143917051 no 826 0.251578247146727 1276 721395
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.667837821207846 0.239706524064451 no 827 0.252118560663999 1233 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_401 neomycin 50 µM 0.667597136080782 0.239784651208604 no 828 0.252195393162049 1206 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_311 1315-0136 58 µM 0.666797114226841 0.24004444061053 no 829 0.252450868146035 1282 6759207
SGTC_334 1502-1024 68.5 µM 0.66612767220929 0.240261944975285 no 830 0.252664749181501 1268 3296216
SGTC_2055 5235184 200 µM 0.664048086149346 0.240938295158646 no 831 0.253329767486134 1250 2836034
SGTC_1531 st059297 52.4 µM 0.663263203573217 0.241193833867986 no 832 0.253580999323331 1261 7566702
SGTC_1030 k029-0042 36.7 µM 0.66184010746287 0.241657534858949 no 833 0.254036849505566 1258 6080581
SGTC_2202 7226349 200 µM 0.661440028022158 0.241787983661528 no 834 0.254165081464438 1205 844334
SGTC_3160 9100216 49.47 µM 0.661324714436752 0.241825589585429 no 835 0.254202047642676 1203 17191039
SGTC_3211 9128781 49.47 µM 0.660722964018504 0.242021883172502 no 836 0.254394997041449 1239 17194361
SGTC_2809 7964133 12.99 µM 0.660404382777081 0.242125840725 no 837 0.254497180192197 1248 1253665
SGTC_1714 st033236 13.627 µM 0.659223662879595 0.242511337334815 no 838 0.254876076955519 1301 2916566
SGTC_3309 9129340 25.759 µM 0.658775862027816 0.242657628013268 no 839 0.255019854852228 1277 17158987
SGTC_2977 9011197 71.43 µM 0.656969477756676 0.24324823491346 no 840 0.255600271179014 1289 2704722
SGTC_2081 5214970 32.255 µM 0.656126159608433 0.243524228075551 no 841 0.255871477053708 1221 2063512
SGTC_1146 3579-1023 7 µM 0.655284818551992 0.243799742657559 no 842 0.256142196686589 1307 X1146
SGTC_2938 9059746 27.26 µM 0.65521150908788 0.243823757328328 no 843 0.25616579266058 1225 6471769
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.653833572236626 0.244275378494812 no 844 0.256609517290704 1301 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_726 3448-4391 34.2 µM 0.651767375327175 0.244953422222383 no 845 0.257275625470904 1347 1356692
SGTC_1830 st055982 50.3 µM 0.650380238337974 0.245409192974751 no 846 0.257723319510434 1233 455313 An antimicrobial agent.
SGTC_203 k066-0004 30.888 µM 0.650186791415702 0.245472789900643 no 847 0.257785786004145 1335 6795412
SGTC_1445 4239-0156 97.7 µM 0.6478613522993 0.246237985601071 no 848 0.258537314690746 1341 4008346
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.647741422684226 0.246277483605083 no 849 0.258576103941944 1254 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_491 tetrandrine 80.3 µM 0.646849993701241 0.246571176109712 no 850 0.258864516328764 1292 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1191 1487-1166 10.6 µM 0.645677787772835 0.246957659500737 no 851 0.259244024294521 1329 3955771
SGTC_89 0302-0250 142.109 µM 0.645276190290823 0.247090143137508 no 852 0.259374109737684 1319 4203518 YLR208W SEC13
SGTC_2869 9037858 32.47 µM 0.642446700844301 0.248024644518473 no 853 0.260291592743723 1236 27187042
SGTC_930 2810-3379 265 µM 0.637946992171488 0.249514648011508 no 854 0.26175409321606 1394 1015764
SGTC_3159 9100096 49.47 µM 0.636757081697525 0.249909460694792 no 855 0.262141542892684 1246 25236875
SGTC_2349 9023730 187.07 µM 0.636258959382405 0.250074836244703 no 856 0.262303824945825 1316 4126287
SGTC_1727 st034309 9.9045 µM 0.634758933488982 0.25057319210601 no 857 0.26279282531754 1359 870305
SGTC_705 1124-0212 310 µM 0.633281569354651 0.251064532823372 no 858 0.263274893403569 1296 9554485
SGTC_2140 5586273 200 µM 0.632911902681538 0.251187555983405 no 859 0.263395587285782 1286 854421
SGTC_19 0279-0214 38.434 µM 0.632586488950604 0.251295878372209 no 860 0.263501856229182 1334 3566274 YBR002C RER2
SGTC_249 wiskostatin 11.211 µM 0.63102875424134 0.251814752611556 no 861 0.264010861772023 1303 2775510 A n-wasp and actin depolymerizer.
SGTC_2555 cholic acid 100 µM 0.629080885747003 0.252464373598198 no 862 0.264648051722955 1298 6708657 Influences liver metabolism.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.628927468241688 0.252515576367191 no 863 0.264698271119467 1336 23847180
SGTC_2052 5265182 7.135 µM 0.627859266540919 0.252872238057001 no 864 0.265048068539155 1337 1239884
SGTC_1876 myriocin 605 nM 0.626963909916493 0.25317139268348 no 865 0.265341446251068 1369 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1175 0741-0056 27.6 µM 0.625159508283675 0.253774840524948 no 866 0.265933187265149 1359 765927
SGTC_328 k915-0120 63.5 µM 0.625116231030721 0.253789323047551 no 867 0.265947387946555 1299 6624543
SGTC_3075 9116269 49.47 µM 0.623803281008348 0.254228901584635 no 868 0.266378392320933 1335 17015205 YNL244C SUI1
SGTC_3268 9137683 49.47 µM 0.622807804122185 0.254562455325199 no 869 0.266705414647904 1314 1953228
SGTC_3297 9117502 71.43 µM 0.62218105014247 0.254772578886683 no 870 0.266911412529999 1290 7453720
SGTC_354 2783-3500 4.88 µM 0.621932308425406 0.254855996412623 no 871 0.266993189796254 1270 6740761
SGTC_1218 1348-1416 30.7 µM 0.621262871110747 0.25508056856415 no 872 0.267213339371805 1295 6787668
SGTC_2905 7799065 20.05 µM 0.620627301891402 0.255293874935307 no 873 0.267422435912394 1272 1296806
SGTC_961 1252-1571 372 µM 0.62030812140182 0.255401031760293 no 874 0.267527474534744 1360 6813498
SGTC_1332 1480-0653 17.5 µM 0.618523274678581 0.256000682124927 no 875 0.268115230186146 1264 5749438
SGTC_3157 9099274 49.47 µM 0.617873191878726 0.256219271110563 no 876 0.268329465855398 1283 17217662
SGTC_1033 k072-0102 21.3 µM 0.617309483507784 0.256408895620547 no 877 0.268515306391532 1292 5965931
SGTC_176 1486-1328 72.834 µM 0.616951733716308 0.256529276137615 no 878 0.268633281092749 1298 22310231
SGTC_2942 9052777 62.25 µM 0.61684479456058 0.256565266194251 no 879 0.268668551340443 1395 6469503
SGTC_3191 9110352 49.47 µM 0.614535509523259 0.257343090356166 no 880 0.269430757748042 1334 17122424
SGTC_2016 5121758 140 µM 0.614214856599313 0.257451190983621 no 881 0.269536678621199 1295 2795203
SGTC_960 1222-0186 7.7 µM 0.613293292316049 0.257762006091271 no 882 0.269841213902516 1343 3126296
SGTC_2425 5628681 7.85 µM 0.613226648877974 0.257784490409497 no 883 0.269863243219561 1319 5714958
SGTC_109 0132-0036 33.701 µM 0.612249494715175 0.258114281802749 no 884 0.270186349690807 1214 67274 A color developer.
SGTC_2608 thymoquinone 42.66 µM 0.611945899710228 0.258216790222347 no 885 0.270286776004507 1244 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_108 0509-0257 621.132 µM 0.61089130070033 0.258573037976799 no 886 0.270635772183499 1295 536624
SGTC_2315 7733312 200 µM 0.609376126567542 0.259085315002976 no 887 0.271137579132991 1302 726316
SGTC_2469 5655019 90.81 µM 0.609352673962671 0.259093248399051 no 888 0.271145349990745 1425 2788239
SGTC_1752 st044819 83.042 µM 0.608484948055157 0.259386865400454 no 889 0.271432942988359 1264 441209 YML126C ERG13
SGTC_721 1187-1332 279 µM 0.607242687041494 0.259807514829054 no 890 0.271844933620782 1267 25730
SGTC_2738 aclarubicin 5.55 µM 0.606431218741084 0.260082480893612 no 891 0.272114221564271 1290 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_805 3852-0218 479 µM 0.606246556192013 0.260145074754772 no 892 0.272175520847071 1287 6615355
SGTC_515 4092-1064 102 µM 0.605934292224394 0.260250938502258 no 893 0.272279193414584 1404 717353
SGTC_1474 0330-0125 5.35 µM 0.603559756371806 0.261056679401983 no 894 0.273068187719695 1337 X1474
SGTC_546 peri-Naphthalide 147 µM 0.60335991923819 0.261124547723502 no 895 0.273134639879059 1309 223824 A penicillin ester.
SGTC_565 1418-0001 44.5 µM 0.603112959126251 0.261208432391499 no 896 0.273216772986925 1365 2862145
SGTC_2568 diosmetin 100 µM 0.601172341480579 0.26186808142602 no 897 0.273862602176606 1338 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3291 9121177 71.43 µM 0.600917404495118 0.26195480230134 no 898 0.273947500164573 1297 17015612
SGTC_231 b-estradiol 524 µM 0.599953344256214 0.26228287581666 no 899 0.274268664809371 1280 450 A steroid.
SGTC_1312 1218-2183 165 µM 0.599280286881759 0.262512044599971 no 900 0.27449299563664 1346 6744073
SGTC_3005 9076496 71.4286 µM 0.599127081672153 0.262564223640009 no 901 0.274544071763358 1352 21368410
SGTC_1397 3532-0190 20.1 µM 0.598343980386167 0.262831017254287 no 902 0.274805218217328 1305 5322280
SGTC_2047 4141938 200 µM 0.597796392194311 0.263017656591451 no 903 0.274987899135539 1350 3807862
SGTC_1743 st037606 46.3785 µM 0.595827416800881 0.263689319170662 no 904 0.275645263017966 1382 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1938 st074717 56.4 µM 0.595746652594904 0.263716888358149 no 905 0.2756722435142 1273 17250979
SGTC_3184 9108758 49.47 µM 0.59537397195532 0.263844123438947 no 906 0.275796759894888 1353 902885
SGTC_512 prima-1 270 µM 0.595292389011939 0.263871980449096 no 907 0.275824021270336 1397 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2332 7982454 138.89 µM 0.595185317752403 0.263908542880597 no 908 0.275859801711574 1358 2981748
SGTC_1320 1313-0481 95.3 µM 0.594862314609128 0.264018856847111 no 909 0.275967754808789 1360 6813365 YLR208W SEC13
SGTC_1428 4049-0204 61.7 µM 0.589143687576968 0.265975799478698 no 910 0.277882444469291 1419 X1428
SGTC_3305 9127027 53.8275 µM 0.588421629624288 0.266223412772234 no 911 0.278124661548502 1343 41905295
SGTC_1132 3456-3614 2.5 µM 0.587824725824239 0.26642819537543 no 912 0.278324972913804 1494 3125502
SGTC_2998 9066762 71.4286 µM 0.587037497724066 0.266698395236694 no 913 0.278589261552899 1423 4945196
SGTC_870 0573-2213 57.6 µM 0.583852516139676 0.26779298669545 no 914 0.279659771122036 1346 3916321
SGTC_1631 benzylvanillin 81.9 µM 0.583464279276669 0.267926567732963 no 915 0.279790398460552 1390 75506
SGTC_1062 mesoridazine 14.2 µM 0.583268423508942 0.267993968750743 no 916 0.279856307910212 1367 4078 A neuroleptic.
SGTC_1297 1068-0111 14.1 µM 0.582013689210296 0.26842597041743 no 917 0.280278730089211 1316 767057
SGTC_2406 ethylparaben 405.7 µM 0.58141625714032 0.268631787670652 no 918 0.28047997163137 1238 8434 A possible steroid mimic.
SGTC_340 k038-0059 454 µM 0.581132731807494 0.268729490792559 no 919 0.280575499968008 1390 23733424
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.58098842939915 0.268779224405394 no 920 0.280624125897756 1408 279621
SGTC_1507 4075-3230 155 µM 0.580890620179276 0.268812936837823 no 921 0.280657087224129 1300 659771
SGTC_184 1494-0393 24.714 µM 0.580626611276525 0.268903944814647 no 922 0.280746066546081 1339 3090647
SGTC_2982 9019404 25.97 µM 0.577836810501165 0.269866577028776 no 923 0.281687150195154 1220 22333232
SGTC_2804 7954240 19.48 µM 0.574126160466641 0.271149619724559 no 924 0.282941215879052 1404 828705
SGTC_2452 5863136 48.41 µM 0.573226861829719 0.271461030227692 no 925 0.283245549410126 1345 2184096
SGTC_1367 1812-0510 76.9 µM 0.570181902684807 0.272516764446593 no 926 0.284277164621525 1395 1142582 YDR527W RBA50
SGTC_370 0180-0345 38.7 µM 0.570116062168238 0.272539614864765 no 927 0.284299490845214 1359 3989527
SGTC_1682 st012968 530 nM 0.568954335613985 0.272942956704469 no 928 0.284693564898354 1337 24207270
SGTC_2611 pyromycin 23.93 µM 0.568370374376912 0.27314581493602 no 929 0.284891751223827 1346 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1158 4092-0494 91.8 µM 0.567389437631559 0.273486743799575 no 930 0.285224812212885 1475 1148199
SGTC_1847 st056231 15 µM 0.565964206923343 0.273982464036887 no 931 0.285709056293787 1390 5393180
SGTC_1831 st055328 12 µM 0.565806926914102 0.274037195978267 no 932 0.285762518551617 1424 1103068
SGTC_135 0933-0004 26.348 µM 0.565141643679843 0.27426876793504 no 933 0.285988712709639 1349 21230617 YGL099W LSG1
SGTC_680 0417-1641 114 µM 0.564833401726108 0.274376093619627 no 934 0.286093542820956 1366 2835990
SGTC_3131 9127911 49.47 µM 0.562962648915201 0.27502790885219 no 935 0.28673015909427 1431 45595681
SGTC_417 st075190 100 µM 0.562915263000637 0.27504442914369 no 936 0.28674629321543 1473 222757
SGTC_265 mycophenolic acid 32.932 µM 0.562702873034313 0.275118481290468 no 937 0.286818613777694 1457 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2980 9014342 25.29 µM 0.561888349602725 0.27540256502942 no 938 0.287096045946433 1393 2996599
SGTC_3290 9121031 71.43 µM 0.560888521054848 0.275751475381718 no 939 0.287436767901202 1360 17014854
SGTC_735 3076-0345 636 µM 0.560773675673818 0.275791566901686 no 940 0.28747591719629 1484 2888990
SGTC_3000 9075062 71.4286 µM 0.560415053154064 0.275916777327351 no 941 0.287598183172029 1381 17057871
SGTC_3253 9135987 49.47 µM 0.559514886706549 0.276231186806226 no 942 0.287905187163106 1397 4182430
SGTC_1365 1672-3266 55.4 µM 0.558888248113153 0.27645016242214 no 943 0.288118995122781 1417 6415873
SGTC_38 0929-0051 58.268 µM 0.558756741344336 0.276496127586772 no 944 0.28816387450519 1449 1379719
SGTC_2663 amphotericin b 100 µM 0.558125447667216 0.276716833920158 no 945 0.288379362327086 1369 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_590 k048-0076 22.4 µM 0.558009920475437 0.276757232677738 no 946 0.288418804973424 1464 6832814
SGTC_610 4215-0184 155 µM 0.557856637294826 0.276810838804452 no 947 0.288471141982882 1438 5605015
SGTC_200 k038-0079 37.545 µM 0.557542567198332 0.276920691144484 no 948 0.288578392055943 1415 3436683
SGTC_1579 chlormadinone acetate 49.4 µM 0.556050253099397 0.277442949537132 no 949 0.289088250722174 1478 45114258 A steroidal progestin.
SGTC_2165 5727197 32.143 µM 0.555738261576455 0.277552196615296 no 950 0.289194898143812 1505 1361712
SGTC_2692 st077426 47.7 µM 0.555342046944755 0.277690965582978 no 951 0.289330362031659 1402 25238571
SGTC_2134 5324836 1.464 µM 0.554429085917993 0.278010847131396 no 952 0.289642612497072 1446 699272
SGTC_2829 7992743 58.44 µM 0.552395233458689 0.278724110249935 no 953 0.290338797806964 1448 16462845
SGTC_3176 9106582 49.47 µM 0.551490449084491 0.279041700203552 no 954 0.290648756068379 1339 17018027
SGTC_1901 st060216 58.6 µM 0.55097997364072 0.279220960707304 no 955 0.29082370145771 1397 688792
SGTC_3342 9147791 14.508 µM 0.550979723273412 0.279221048640974 no 956 0.290823787273338 1368 1838168
SGTC_281 1672-3440 14.9 µM 0.550955531748685 0.27922954521926 no 957 0.290832079190111 1422 6833000
SGTC_3038 9091290 49.47 µM 0.549151842884098 0.2798633928313 no 958 0.291450624878515 1451 25236843
SGTC_736 0958-0254 92.6 µM 0.548712737514819 0.280017807648367 no 959 0.291601301737496 1469 6812352
SGTC_3033 9090887 49.47 µM 0.547238395754371 0.280536573328634 no 960 0.292107480401394 1372 19325384
SGTC_123 0083-0120 66.675 µM 0.546343841546661 0.280851560025107 no 961 0.292414802593192 1346 16001701
SGTC_1738 st035555 74 µM 0.546089736594016 0.280941065573682 no 962 0.292502127214634 1415 5331140
SGTC_1282 0886-0010 32.4 µM 0.545594009679289 0.281115719353404 no 963 0.292672521484167 1479 2836211 YNL267W PIK1
SGTC_2536 dehydroabietamide 32.04 µM 0.543872743245169 0.281722560300456 no 964 0.293264523329527 1524 3983547
SGTC_1115 galangin 695.678 nM 0.542295292076397 0.282279252450187 no 965 0.293807549170294 1452 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2444 5485484 36.41 µM 0.541877857176327 0.282426656297528 no 966 0.293951325832491 1523 6790631
SGTC_1667 st014849 34.6 µM 0.541027124481932 0.282727180023797 no 967 0.294244443468684 1444 5348460
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.540727256977741 0.282833145678339 no 968 0.294347794175052 1470 688801
SGTC_2917 7979103 53.79 µM 0.539741379532158 0.283181664430563 no 969 0.294687699434855 1502 2980565
SGTC_683 panaxydol 45 µM 0.539309540370339 0.283334389289105 no 970 0.294836643496259 1420 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_845 0330-0138 4.51 µM 0.536412272785671 0.284360061201045 no 971 0.295836825634301 1481 9039800
SGTC_268 camptothecin 39.6153 µM 0.535179786830019 0.284796915199004 no 972 0.296262771064414 1439 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1244 0416-0015 52.5 µM 0.534193804081694 0.285146626682642 no 973 0.296603727703493 1432 96201
SGTC_2090 5301565 104.445 µM 0.533238857428113 0.285485525174896 no 974 0.296934123182302 1452 2056344
SGTC_450 aminopyrene 156 nM 0.530915976696756 0.286310685754277 no 975 0.297738502950121 1472 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_116 0155-0182 31.788 µM 0.529727812921643 0.286733196311865 no 976 0.298150330674306 1421 771486
SGTC_1303 1160-0052 261 µM 0.529342750862935 0.286870187617727 no 977 0.298283852128128 1440 3562476
SGTC_1591 genipin 88.4 µM 0.529289224198427 0.286889232945184 no 978 0.298302414818851 1472 442424 A DNA cross-linking agent.
SGTC_1596 piperlongumine 63 µM 0.528913685279316 0.287022870327138 no 979 0.298432664000774 1533 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2237 6667747 47.222 µM 0.528890033742443 0.287031287830332 no 980 0.298440867993677 1452 729940 YDL015C TSC13
SGTC_1223 0764-0573 147 µM 0.52813484744093 0.287300117563851 no 981 0.298702872898824 1419 1609797
SGTC_874 0599-0792 117 µM 0.527443972849616 0.287546158043794 no 982 0.298942657000067 1519 765305
SGTC_1441 4106-0040 13 µM 0.527402019630241 0.287561102009771 no 983 0.298957220656376 1426 2904180
SGTC_3088 9117578 49.47 µM 0.526511266756687 0.28787847967392 no 984 0.299266512967829 1476 678341
SGTC_2158 5657123 3.6195 µM 0.525356267290181 0.288290255254986 no 985 0.299667774503751 1443 2858827
SGTC_2190 6049624 200 µM 0.524895827358729 0.288454486774878 no 986 0.299827805125489 1447 2265554
SGTC_2298 7976326 193.81 µM 0.524346285182328 0.288650557334855 no 987 0.300018854778252 1368 2235818
SGTC_2687 chenodiol 100 µM 0.523014887480228 0.289125845372512 no 988 0.300481946578997 1491 5702181 A cholesterol synthesis inhibitor.
SGTC_748 act1.228 77.9 µM 0.522868007014311 0.289178301919415 no 989 0.300533054867541 1377 4421505 YNR035C ARC35
SGTC_2684 capsaicin 100 µM 0.521186168292751 0.28977926858624 no 990 0.301118544333851 1427 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3195 9113082 49.47 µM 0.520460474838122 0.290038759418291 no 991 0.30137133472997 1458 17018038
SGTC_1477 0139-0234 16 µM 0.518990481959909 0.29056472766584 no 992 0.301883689322897 1487 620880
SGTC_1073 triclabendazole 3.09 µM 0.51789383076745 0.290957403479521 no 993 0.302266173291477 1483 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1377 2944-0135 198 µM 0.516352710242703 0.291509648291444 no 994 0.302804043993329 1519 1894137
SGTC_289 k017-0060 526 µM 0.515510099728363 0.291811795732898 no 995 0.303098306916936 1459 5512909
SGTC_2232 chlorophetanol 41.5365 µM 0.51471395483164 0.292097415290434 no 996 0.303376460229969 1545 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2073 5212005 126 µM 0.51425207877071 0.292263174437691 no 997 0.303537880552451 1375 691789
SGTC_1687 st020778 55.3625 µM 0.514116100946746 0.292311982808858 no 998 0.303585410531054 1477 4259299
SGTC_2709 st078560 56 µM 0.510215061091386 0.293713847700084 no 999 0.304950400875605 1582 17250903
SGTC_160 3453-0671 289.699 µM 0.509764488366489 0.293875964273623 no 1000 0.305108233663932 1383 5322268
SGTC_372 0155-0182 15.9 µM 0.509098291161451 0.29411573858481 no 1001 0.305341664776634 1488 771486
SGTC_863 0466-0191 129 µM 0.508286895280224 0.294407894118809 no 1002 0.305626079493567 1485 765160 YPR165W RHO1
SGTC_1635 st007035 42.4 µM 0.50815968388354 0.294453710680242 no 1003 0.305670680938393 1493 3716403
SGTC_2262 9014885 67.46 µM 0.507553879426134 0.294671942855164 no 1004 0.305883120908866 1454 6457424
SGTC_3072 9116419 49.47 µM 0.506765972213282 0.294955886432267 no 1005 0.306159517341462 1423 17170162
SGTC_2771 fluoxetine 41.05 µM 0.506326588598095 0.295114284882502 no 1006 0.306313700272897 1509 3386 A selective serotonin reuptake inhibitor.
SGTC_53 0973-0023 39.979 µM 0.505104394400851 0.295555093612964 no 1007 0.306742757534072 1479 674768
SGTC_352 k048-0007 5.11 µM 0.504911927999246 0.295624538043785 no 1008 0.306810347966817 1442 6811911
SGTC_3334 9142812 21.919 µM 0.501691624741945 0.296787577110787 no 1009 0.307942228388349 1516 45283678
SGTC_2707 st078556 66.6 µM 0.500582058346385 0.297188790779796 no 1010 0.308332645991969 1533 17250899
SGTC_2161 5662504 8.5105 µM 0.499537993055656 0.297566545822726 no 1011 0.308700214134597 1462 2859334
SGTC_542 3381-0244 89.3 µM 0.494872759405888 0.299257153400357 no 1012 0.310344970241253 1582 1112843
SGTC_3140 9094243 49.47 µM 0.493909347694229 0.299606820873357 no 1013 0.310685101307188 1474 19291112
SGTC_1764 st044502 93.5 µM 0.492449035767171 0.300137189504898 no 1014 0.311200970836081 1465 8407
SGTC_1094 duloxetine 25.4 µM 0.492294370294103 0.300193387098151 no 1015 0.31125562968194 1488 60834 A selective serotonin reuptake inhibitor.
SGTC_1292 0kpi-0043 232 µM 0.491867225325892 0.300348614636414 no 1016 0.311406604516572 1477 3333905
SGTC_2595 hexamethylquercetagetin 100 µM 0.49147477464724 0.300491265985412 no 1017 0.311545344581461 1498 386331
SGTC_2208 7283366 200 µM 0.490554809378634 0.300825782757287 no 1018 0.311870677686123 1562 898663
SGTC_884 0851-0618 334 µM 0.489732044844033 0.301125097725278 no 1019 0.312161761489359 1559 9642473
SGTC_658 3253-0951 102 µM 0.488463942591688 0.301586685496626 no 1020 0.312610629896305 1520 1184878
SGTC_1151 3909-8316 15.3 µM 0.486782686808071 0.302199150895129 no 1021 0.313206170405452 1498 800431
SGTC_3136 9095672 49.47 µM 0.486734973294868 0.302216540615121 no 1022 0.313223078780106 1479 17217380
SGTC_3312 9133330 71.43 µM 0.486477093842521 0.302310535418438 no 1023 0.313314471057775 1573 17617324
SGTC_2793 7325131 81.82 µM 0.485675023491274 0.302602966837471 no 1024 0.313598797437502 1550 4176441
SGTC_3111 9122088 49.47 µM 0.485587225728347 0.302634985222687 no 1025 0.313629927646342 1506 16876704
SGTC_2115 tiliquinol 12.7705 µM 0.48526003335654 0.302754320211579 no 1026 0.31374595102422 1526 71208 A bioactive hydroxyquinoline.
SGTC_3239 9133757 49.47 µM 0.484479808717561 0.303038972064043 no 1027 0.314022695304563 1553 17036923
SGTC_1607 st000305 50.6 µM 0.484266162012271 0.303116938354166 no 1028 0.314098493661171 1544 5457690
SGTC_882 0843-0131 351 µM 0.483134626089376 0.303530020316974 no 1029 0.314500074800288 1501 5425421
SGTC_2993 9054257 71.4286 µM 0.482510804448547 0.303757862005749 no 1030 0.314721562501441 1477 6470217 YGL055W OLE1
SGTC_3315 9136395 68.55 µM 0.482188027342215 0.303875781552622 no 1031 0.314836190603822 1560 16876844
SGTC_1909 st060837 51.5 µM 0.482108822354862 0.303904720479619 no 1032 0.31486432146351 1464 678937
SGTC_1056 3448-1962 115 µM 0.480962441696646 0.304323708246745 no 1033 0.31527159626555 1542 715507
SGTC_2079 5212404 121 µM 0.480960414809188 0.304324449276458 no 1034 0.315272316557159 1606 758462
SGTC_2371 9071574 200 µM 0.480929043742708 0.304335918635534 no 1035 0.315283464930169 1494 45596039
SGTC_136 0097-0015 404.482 µM 0.479256615387796 0.304947642014354 no 1036 0.315878041062223 1529 4861337
SGTC_70 0141-0289 43.283 µM 0.477772447485148 0.305490962428694 no 1037 0.316406086785411 1608 352408
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.475246621413683 0.306416595540923 no 1038 0.317305600264474 1539 77254
SGTC_2061 5245884 80.95 µM 0.475172849472514 0.306443649172107 no 1039 0.31733188866451 1497 573863
SGTC_1729 st035615 45.989 µM 0.473395914548952 0.307095604859793 no 1040 0.317965372024915 1505 17385451
SGTC_3298 9116858 71.43 µM 0.47332339425132 0.307122225462176 no 1041 0.317991237091439 1586 2506942
SGTC_3175 9106517 49.47 µM 0.471937279041805 0.307631233076635 no 1042 0.318485779044643 1495 41468073
SGTC_712 r015-0009 80.6 µM 0.471575203788942 0.307764255008886 no 1043 0.318615014575212 1585 6813872 YLR060W FRS1
SGTC_56 0957-0365 83.25 µM 0.471226007023006 0.307892569486519 no 1044 0.318739674292066 1481 6752360
SGTC_2416 tofa 880 nM 0.469895010599477 0.308381867558191 no 1045 0.319215014580588 1434 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2734 clemastine 41.6 µM 0.469455601875644 0.308543476880875 no 1046 0.319372006451693 1543 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3304 9125678 46.087 µM 0.468069102964241 0.309053657849268 no 1047 0.319867586758394 1520 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2343 7990716 14.84 µM 0.467012147089573 0.309442826632992 no 1048 0.320245593697009 1565 6456862
SGTC_2220 6782180 200 µM 0.466734945770869 0.30954492694536 no 1049 0.320344762158443 1536 833803
SGTC_2459 5811157 9.22 µM 0.466309822412349 0.309701539275561 no 1050 0.320496874490657 1497 2870684 YBR192W RIM2
SGTC_595 3909-8003 73.7 µM 0.464534859637892 0.310355795599304 no 1051 0.321132295074084 1557 699517
SGTC_2591 skatole 100 µM 0.462792545694819 0.310998601663041 no 1052 0.321756537448815 1544 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1276 0871-0068 94.2 µM 0.459755250363706 0.312120554810539 no 1053 0.322845953462485 1613 3414906
SGTC_926 2268-1401 59.4 µM 0.45722882550748 0.313055126452299 no 1054 0.32375329076072 1503 2931578
SGTC_813 k007-0158 173 µM 0.456854873991237 0.313193560386582 no 1055 0.323887680487735 1653 6523916
SGTC_2423 st077119 87.2 µM 0.455032327332302 0.313868629552793 no 1056 0.324542990967895 1494 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3056 9094900 49.47 µM 0.45486993561554 0.313928809541451 no 1057 0.324601406547083 1468 25236784
SGTC_1329 1447-1697 50.6 µM 0.453905023704999 0.314286493778845 no 1058 0.324948593796449 1533 2840515
SGTC_1022 4477-0945 21.3 µM 0.453351019209929 0.314491937164101 no 1059 0.325148000218976 1529 4648966
SGTC_2625 euphol 100 µM 0.453102321735756 0.314584181191008 no 1060 0.325237531802536 1681 6708538 A triterpene alcohol.
SGTC_143 4032-1194 15.74 µM 0.45128244830053 0.315259539806138 no 1061 0.325892996612206 1556 1806963
SGTC_1676 st018489 23.4 µM 0.450936575812677 0.315387963703901 no 1062 0.326017630649532 1560 3696235
SGTC_715 0868-0130 184 µM 0.450153019812853 0.315678983804806 no 1063 0.326300054419164 1708 2876258
SGTC_2357 9067248 200 µM 0.44904278641477 0.316091530713637 no 1064 0.326700395877709 1568 9150235
SGTC_2693 st077581 40.7 µM 0.447664631823285 0.316603951992513 no 1065 0.327197625288144 1573 25238761
SGTC_1495 4469-0029 237 µM 0.447407938384941 0.316699433907657 no 1066 0.327290272571186 1534 793680
SGTC_1902 st060212 70.5 µM 0.446381297671989 0.317081434139207 no 1067 0.327660920020427 1528 688944
SGTC_2031 5180455 200 µM 0.444961418999434 0.317610074645383 no 1068 0.328173817830525 1529 29949
SGTC_57 miconazole 162.5 nM 0.443505360269597 0.318152571979518 no 1069 0.328700121470254 1497 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_170 4197-0004 226 µM 0.443372407203381 0.318202127004465 no 1070 0.328748195332489 1613 218692
SGTC_1941 st076221 61.8 µM 0.442332636767128 0.318589788350732 no 1071 0.329124258634589 1638 2828568
SGTC_3099 9120367 49.47 µM 0.44186829742115 0.318762973850412 no 1072 0.329292256400653 1557 24824940
SGTC_6 0844-0013 19.835 µM 0.441561247038901 0.318877516743517 no 1073 0.32940336602707 1625 1584900
SGTC_17 0960-0276 49.807 µM 0.441177233405418 0.319020794563137 no 1074 0.329542346871609 1571 6821114
SGTC_1010 4112-3296 15.2 µM 0.439048476573175 0.319815536683943 no 1075 0.330313205575605 1714 704384
SGTC_2120 5538279 151.968 µM 0.438819151337014 0.319901201570344 no 1076 0.330396291163813 1598 2058197
SGTC_2001 4023502 57.655 µM 0.438628608187662 0.319972386639484 no 1077 0.33046533218369 1617 108941 YCR052W RSC6
SGTC_2930 9013230 14.89 µM 0.437130531463757 0.320532284317348 no 1078 0.331008343148476 1678 2995857
SGTC_423 5-fluorouracil 457 µM 0.436766403158046 0.320668436990101 no 1079 0.331140383263026 1479 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.436015532546814 0.320949274194364 no 1080 0.331412730063972 1609 364106
SGTC_2278 7948257 134.34 µM 0.435429396038676 0.321168569524648 no 1081 0.331625388466374 1708 1247028
SGTC_989 1501-0895 10.3 µM 0.435331698719554 0.321205127769324 no 1082 0.331660839679556 1654 2830112
SGTC_2091 4-phenylthiadiazole 200 µM 0.433522245814655 0.321882536254606 no 1083 0.332317704191615 1589 270010
SGTC_2640 pentamidine 10.38 µM 0.4328413138232 0.322137611652033 no 1084 0.332565028548118 1692 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1253 0550-0034 176 µM 0.431469372974157 0.322651791625148 no 1085 0.333063558652252 1570 5969915
SGTC_3119 9125183 49.47 µM 0.429693382058645 0.323317906517773 no 1086 0.333709349061213 1559 22695334
SGTC_1666 st014829 29 µM 0.428839143515712 0.323638504885747 no 1087 0.334020145188787 1547 3858230
SGTC_1045 1348-1485 165 µM 0.427772143503635 0.324039137194181 no 1088 0.334408509881776 1550 6810614
SGTC_1461 k072-0203 53.8 µM 0.42742988631816 0.324167689575395 no 1089 0.334533121594881 1528 5418714
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.425433918037748 0.324917795907211 no 1090 0.335260192360886 1717 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_306 1672-3436 11.6 µM 0.423997516347532 0.325458050875078 no 1091 0.335783812300549 1636 6797378
SGTC_325 2810-4341 181 µM 0.423360505686245 0.325697758878586 no 1092 0.336016127691655 1707 774970
SGTC_1992 st073643 23.3 µM 0.423223702891395 0.325749247368234 no 1093 0.336066027332166 1595 3161292
SGTC_2960 9079389 5.97 µM 0.423129791480053 0.325784594745278 no 1094 0.336100283755584 1708 16457355
SGTC_3151 9099821 49.47 µM 0.423034179434696 0.325820583834049 no 1095 0.336135161924217 1546 17174189
SGTC_2659 sanguinarine 24.21 µM 0.423026403910114 0.325823510671011 no 1096 0.336137998407712 1586 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1220 1838-0075 193 µM 0.420511377286599 0.326770770988644 no 1097 0.337055959879448 1620 5529645
SGTC_790 1575-0012 79.1 µM 0.42029128052647 0.326853721562446 no 1098 0.337136339453906 1638 378741 YLR208W SEC13
SGTC_1178 0988-0033 191 µM 0.419544547087211 0.327135215929015 no 1099 0.337409102703206 1643 5392207
SGTC_1113 artemisinin 1.17947 µM 0.416548798009457 0.328265504010957 no 1100 0.338504233666965 1711 2240 An anti-malaria and mitochondrial poison.
SGTC_704 1310-0270 142 µM 0.416127387460559 0.328424627588981 no 1101 0.338658395095553 1559 5718033
SGTC_155 k072-0202 43.6 µM 0.414081811729868 0.329197473730442 no 1102 0.339407096292504 1596 5857737
SGTC_817 1391-0715 46 µM 0.414024601217358 0.329219099150609 no 1103 0.339428045045138 1579 1353946
SGTC_2797 7859098 81.82 µM 0.413662079463922 0.32935614468037 no 1104 0.339560801036139 1596 972681
SGTC_256 clotrimazole 625 nM 0.413342120214357 0.32947711918783 no 1105 0.339677987117755 1611 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_998 3996-0085 177 µM 0.412940948549562 0.329628824799696 no 1106 0.339824939400217 1742 715391
SGTC_1304 1165-0502 251 µM 0.410598214434751 0.33051530386522 no 1107 0.340683586605953 1636 767425
SGTC_2918 7977171 22.06 µM 0.410455524115503 0.330569327979183 no 1108 0.340735911486906 1589 2236483
SGTC_2514 salinomycin 42.74 µM 0.410322567183137 0.330619670103966 no 1109 0.340784669869864 1763 23682228 A polyether potassium ionophore.
SGTC_72 0744-0168 198.391 µM 0.408422594314272 0.331339400405557 no 1110 0.341481724141375 1668 677577
SGTC_756 0508-1999 28.3 µM 0.408057225790416 0.331477877508113 no 1111 0.341615831149411 1531 6753853
SGTC_1670 st016595 4.04 µM 0.407542863730398 0.331672863198344 no 1112 0.341804659505533 1619 597879
SGTC_3193 9111931 49.47 µM 0.407513472739842 0.331684006188708 no 1113 0.341815450479561 1629 17087244
SGTC_1144 3486-0183 12.5 µM 0.40745760654274 0.331705187120412 no 1114 0.341835962246704 1615 6744069
SGTC_386 1509-0011 3.07 µM 0.406862112832544 0.331930994127841 no 1115 0.342054632019561 1610 3107280
SGTC_980 1473-0395 201 µM 0.405232233666131 0.3325493448622 no 1116 0.342653406707849 1578 768876
SGTC_1233 0325-0408 14.2 µM 0.404881949595742 0.332682296753203 no 1117 0.342782143544376 1688 12874
SGTC_2334 9017922 200 µM 0.404542299316397 0.332811232638804 no 1118 0.342906989673124 1767 3163164
SGTC_2866 9034245 58.44 µM 0.403746412647077 0.333113439525029 no 1119 0.343199602965183 1731 6462273
SGTC_1424 4048-1941 275 µM 0.403743066036699 0.333114710498649 no 1120 0.343200833568518 1735 X1424
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.402422073075192 0.333616545961948 no 1121 0.343686714017219 1615 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2989 9073649 71.4286 µM 0.401345045954035 0.334025921073849 no 1122 0.344083051503955 1724 21367202
SGTC_235 0330-0087 5 mM 0.40072953660507 0.334259963273045 no 1123 0.3443096310622 1615 46494818 YHR062C RPP1
SGTC_2914 7968218 45.32 µM 0.39871055184098 0.335028117095742 no 1124 0.345053245996353 1718 2977111
SGTC_806 3966-4455 5.86 µM 0.398209859551247 0.335218720171358 no 1125 0.345237749399857 1570 714982
SGTC_2050 5263056 171 µM 0.398207314940534 0.335219688959813 no 1126 0.345238687174234 1759 763468 YGL055W OLE1
SGTC_1285 0929-0069 65.5 µM 0.397425459608311 0.335517410110122 no 1127 0.345526872058273 1634 1206237
SGTC_3317 9138495 8.753 µM 0.397171787008407 0.335614027804208 no 1128 0.345620392760437 1620 17020139
SGTC_639 0833-0042 114 µM 0.396334524770871 0.335932997642648 no 1129 0.345929130518373 1600 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1472 k841-0093 193 µM 0.395604814334509 0.336211090138171 no 1130 0.346198292470623 1711 X1472
SGTC_3170 9103054 49.47 µM 0.395321468260978 0.336319097441558 no 1131 0.346302828829332 1590 16432970
SGTC_1465 k213-0056 144 µM 0.393859522134733 0.336876584050377 no 1132 0.346842378232388 1612 24048857 YMR208W ERG12
SGTC_614 0462-0418 107 µM 0.392899613221954 0.337242822978323 no 1133 0.347196813628409 1573 5188303
SGTC_833 3852-0053 558 µM 0.391263336070193 0.337867475634001 no 1134 0.347801298317786 1697 3123681
SGTC_1043 0916-0009 19.3 µM 0.389051495532522 0.338712560930293 no 1135 0.348619026642296 1826 3101130
SGTC_1951 sophoraflavanone G 9.2 µM 0.387463478156982 0.339319801479402 no 1136 0.349206558824676 1604 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2335 9018011 154.17 µM 0.386946375177587 0.339517626217066 no 1137 0.349397953885053 1748 6458208
SGTC_2810 7959871 45.46 µM 0.384697881144301 0.340378331666755 no 1138 0.35023063260945 1726 2974535
SGTC_550 4123-0385 25.7 µM 0.384307291513975 0.340527931196273 no 1139 0.350375352171075 1613 5731123
SGTC_1328 1441-0025 69.2 µM 0.383930993332233 0.340672080699554 no 1140 0.350514797075045 1552 4562601
SGTC_3037 9091026 49.47 µM 0.382725814252903 0.341133908257438 no 1141 0.35096153607485 1679 25236398 YIL048W NEO1
SGTC_1650 st011916 45.8 µM 0.380686100208399 0.34191607384682 no 1142 0.351718092034718 1755 242528
SGTC_2886 9058944 51.95 µM 0.380414031338243 0.342020455018487 no 1143 0.351819050330773 1634 4949929
SGTC_889 0919-1524 82.7 µM 0.379686016922101 0.342299822332512 no 1144 0.35208925056378 1626 3905452
SGTC_597 k018-0003 82.8 µM 0.378716643761091 0.342671942315506 no 1145 0.352449146256004 1744 6786234
SGTC_1391 3442-0225 151 µM 0.378675501298301 0.342687739338381 no 1146 0.352464423995822 1671 5227075
SGTC_500 h-89 112 µM 0.37741963753774 0.343170071902087 no 1147 0.352930887739949 1800 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2875 9039966 71.43 µM 0.374507357446697 0.344289557575937 no 1148 0.35401344188531 1769 6463691
SGTC_2373 9071805 200 µM 0.373593137342134 0.344641267540148 no 1149 0.354353520224393 1811 10149009
SGTC_375 3970-0961 9.27 µM 0.37310217243855 0.344830202297567 no 1150 0.354536200933176 1685 2898222
SGTC_2733 amorolfine 100 µM 0.370990425441176 0.34564329256674 no 1151 0.355322331525927 1768 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_159 3970-0959 50 µM 0.370499893445671 0.345832265229416 no 1152 0.355505027966126 1719 6615653
SGTC_2499 avocadenofuran 51.48 µM 0.370424463852259 0.345861327152548 no 1153 0.355533124326314 1593 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3164 9100705 49.47 µM 0.369787829428149 0.346106649282335 no 1154 0.355770292091491 1751 17174235
SGTC_60 0986-0278 202 µM 0.369548119416589 0.346199036419409 no 1155 0.35585960661989 1496 3110598
SGTC_853 0419-0306 21 µM 0.364843030389949 0.348014281632338 no 1156 0.357614291119068 1629 762713
SGTC_2376 9072922 81.32 µM 0.364511462145818 0.348142334255746 no 1157 0.357738058069955 1704 17087968
SGTC_3314 9135860 59.4275 µM 0.364509250920278 0.348143188295643 no 1158 0.357738883520829 1811 25252478
SGTC_1811 st050069 61.5 µM 0.363081489377572 0.348694792127588 no 1159 0.35827200589852 1764 3877702
SGTC_934 2950-0684 338 µM 0.363033783916642 0.348713228268011 no 1160 0.358289823769106 1796 1121253
SGTC_1692 fluoroquinolonic acid 71 µM 0.361682353077496 0.349235647323352 no 1161 0.358794707873552 1715 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3114 9122766 49.47 µM 0.361440503467782 0.349329168666623 no 1162 0.358885087079387 1635 17176985
SGTC_236 1509-0011 5.31 µM 0.360861579759451 0.349553071065494 no 1163 0.359101462968274 1731 3107280
SGTC_1346 1488-2224 62.4 µM 0.358192069835154 0.350586197069252 no 1164 0.360099790714038 1810 3722427
SGTC_1120 ficusin 1.78878 µM 0.35765268225265 0.350795079820197 no 1165 0.360301623917746 1785 6199 A DNA cross-linker.
SGTC_455 paf C-16 10 µM 0.357110237341408 0.351005192043173 no 1166 0.360504640413652 1684 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1491 4138-0063 26.5 µM 0.35447676290898 0.352025896367325 no 1167 0.361490807735016 1798 23883227
SGTC_2280 7785178 200 µM 0.354374371624833 0.352065603647101 no 1168 0.361529169233704 1709 2954328
SGTC_1409 3909-8004 61.9 µM 0.354211296644885 0.352128847358695 no 1169 0.361590269110784 1707 2119279
SGTC_579 4491-1009 110 µM 0.353662131548613 0.352341854545076 no 1170 0.361796052678664 1874 1271041
SGTC_2724 maprotiline 69.64 µM 0.352213210107008 0.352904076545593 no 1171 0.362339185347486 1755 4011 A tricyclic antidepressant.
SGTC_3335 9143315 29.6265 µM 0.351259631851482 0.353274266968982 no 1172 0.362696788433199 1679 4899691
SGTC_114 0364-0001 490.298 µM 0.35101364681358 0.353369783833511 no 1173 0.362789055171124 1641 4003655
SGTC_682 0kpi-0099 17 µM 0.349391817943272 0.353999776693947 no 1174 0.363397587547276 1674 1714895 YML126C ERG13
SGTC_904 1141-0088 396 µM 0.348204222484489 0.354461347088852 no 1175 0.363843408448563 1630 1378119
SGTC_3199 9111318 49.47 µM 0.347935707440308 0.354565737705168 no 1176 0.363944234024879 1773 8548020
SGTC_430 0958-0115 16.4 µM 0.346179959717719 0.355248588832198 no 1177 0.36460373726281 1700 6833180
SGTC_3213 9129884 49.47 µM 0.345837363496182 0.355381886765406 no 1178 0.36473247187592 1583 17190742
SGTC_2675 theaflavin digallate 100 µM 0.344537593259929 0.355887764408828 no 1179 0.365221014632375 1723 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2736 butenafine 14.65 µM 0.344390143908448 0.355945168547071 no 1180 0.365276450040457 1778 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.343253754649769 0.356387690608558 no 1181 0.365703784015649 1789 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_846 0335-0850 148 µM 0.341595861306839 0.357033638752735 no 1182 0.366327526124605 1732 6819598
SGTC_3086 9117350 49.47 µM 0.341491429892875 0.357074341050476 no 1183 0.366366827753499 1684 2679265
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.340644826901649 0.357404365825835 no 1184 0.366685489303447 1732 6708630 An antioxidant.
SGTC_3068 9116768 49.47 µM 0.340489934315268 0.35746475797057 no 1185 0.366743800858939 1710 41904888
SGTC_92 0063-0024 660.874 µM 0.340171113123933 0.357589076610143 no 1186 0.366863835388444 1797 3594437
SGTC_973 1325-0077 65.9 µM 0.339083081340627 0.358013448918476 no 1187 0.367273571687672 1833 2835149
SGTC_1590 st077108 57.8 µM 0.339039018237178 0.358030638846489 no 1188 0.367290168373803 1848 5489485
SGTC_1271 0832-2808 169 µM 0.337930002663565 0.358463383466485 no 1189 0.367707968674859 1848 3663794
SGTC_1100 amiodarone 5.07 µM 0.336396483592408 0.359062071381219 no 1190 0.368285950413153 1880 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1097 itavastatin 7.23 µM 0.33607573038858 0.3591873377059 no 1191 0.368406879715313 1757 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1928 4'-methoxychalcone 40.3 µM 0.335884593770571 0.359261991024022 no 1192 0.368478947604539 1901 641818
SGTC_2266 7929956 200 µM 0.333457797258178 0.360210305114545 no 1193 0.36939437055854 1686 2967153
SGTC_1780 st038448 24.544 µM 0.332145117790489 0.360723617190429 no 1194 0.369889841506502 1811 728868 YDL195W SEC31
SGTC_3322 9139058 2.11 µM 0.332102338478457 0.360740349903056 no 1195 0.369905992200218 1782 4908926 YPR165W RHO1
SGTC_384 k007-0144 5.16 µM 0.331620573854612 0.360928805858958 no 1196 0.370087891112847 1741 6824886
SGTC_233 rapamycin 362 pM 0.330760826318037 0.361265204476952 no 1197 0.37041257647063 1764 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1968 st069590 43.6 µM 0.330570461385189 0.361339704234579 no 1198 0.370484480658631 1813 6384066
SGTC_3138 9097216 49.47 µM 0.328771378935493 0.362044038642344 no 1199 0.371164248923097 1837 25237486
SGTC_2038 4100038 30.985 µM 0.327606213906453 0.36250044618631 no 1200 0.371604711499672 1754 3596803
SGTC_665 3914-0008 307 µM 0.325802775321009 0.363207257521083 no 1201 0.372286789403033 1685 1069549
SGTC_2995 9067767 71.4286 µM 0.325383415012803 0.36337168187911 no 1202 0.372445453045128 1753 11673567
SGTC_2899 9053889 58.44 µM 0.324684483059989 0.363645777668342 no 1203 0.372709939834063 1873 6470052
SGTC_2839 9003951 25.97 µM 0.324392196758373 0.363760422474058 no 1204 0.372820563351714 1804 2990634
SGTC_1638 st008370 60.6 µM 0.32338798523482 0.364154401892383 no 1205 0.37320071376261 1707 24207134
SGTC_910 3454-3003 490 µM 0.323213971326737 0.364222686878303 no 1206 0.373266600352693 1841 820824
SGTC_2151 5563267 85.4165 µM 0.322185066097732 0.364626528716528 no 1207 0.373656248665045 1743 5310824
SGTC_2929 9013348 24.6 µM 0.317217950398909 0.366578211499522 no 1208 0.375539115158205 1747 2995952
SGTC_1356 1502-0781 85.8 µM 0.316978306704188 0.366672460243874 no 1209 0.375630031436834 1754 567702
SGTC_1524 corynanthine 62.1 µM 0.316918309947158 0.366696057445631 no 1210 0.375652794151207 1785 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1782 st039423 80.636 µM 0.315579333381881 0.367222818519509 no 1211 0.376160913106861 1695 2068169
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.315547437781371 0.36723536948451 no 1212 0.376173019569675 1774 368090
SGTC_1267 0828-0272 9.49 µM 0.315109753544645 0.36740761319034 no 1213 0.376339161616739 1862 745334
SGTC_2143 5623677 140.463 µM 0.315046100819325 0.367432664936265 no 1214 0.376363325680427 1824 5375313
SGTC_1721 st082152 9.2685 µM 0.314605814526107 0.367605963460679 no 1215 0.37653048192135 1727 5296051
SGTC_2252 omeprazole 400 µM 0.314550840872595 0.36762760321445 no 1216 0.376551354489079 1834 4594 A proton pump inhibitor.
SGTC_2366 9070441 60.58 µM 0.314050921389109 0.367824410116965 no 1217 0.376741182031384 1693 6837235
SGTC_857 0438-0306 1.35 µM 0.313491783967682 0.368044570887687 no 1218 0.3769535308942 1775 4686136
SGTC_22 0964-0034 14.468 µM 0.313196618399663 0.368160810034056 no 1219 0.377065643706354 1744 138402
SGTC_2310 7668677 200 µM 0.313119193466413 0.368191302744297 no 1220 0.377095053754607 1787 2197143
SGTC_948 3448-0295 75.3 µM 0.312114815150178 0.368586938068835 no 1221 0.377476633847772 1730 678569
SGTC_3226 9131256 49.47 µM 0.312016533451934 0.368625659768734 no 1222 0.377513979137841 1764 17178073
SGTC_2000 st075254 36.4 µM 0.31154273626639 0.368812348354418 no 1223 0.377694029668886 1746 17234175
SGTC_287 k060-0039 29.6 µM 0.311450900151183 0.368848537789065 no 1224 0.37772893194219 1868 5861974
SGTC_2904 7225135 42.03 µM 0.30897296101578 0.369825445883903 no 1225 0.378671047570331 1865 4446116
SGTC_51 1013-0126 23.419 µM 0.308736689502946 0.369918638077173 no 1226 0.378760916065319 1919 1627850
SGTC_447 ml7 120 µM 0.306838067204874 0.370667785534445 no 1227 0.379483315768735 1834 4216 Selective myosin light chain kinase inhibitor.
SGTC_1882 5615643 20 µM 0.306712199373762 0.370717467110361 no 1228 0.379531221654452 1815 2253075
SGTC_1504 k297-0033 30 µM 0.30669594867062 0.37072388161925 no 1229 0.379537406882959 1701 4388117
SGTC_2234 tolnaftate 200 µM 0.303440154681119 0.372009737444891 no 1230 0.380777224124933 1826 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_824 1304-0008 100 µM 0.303353724211293 0.372043892158033 no 1231 0.380810153887586 1778 768245
SGTC_2068 5226020 147 µM 0.302383854709114 0.372427224294279 no 1232 0.381179730554819 1740 1810509
SGTC_3093 9117344 49.47 µM 0.299689969386036 0.373492620242275 no 1233 0.3822068252067 1797 24824913
SGTC_394 menadione 8.33 µM 0.299394158598648 0.373609668597898 no 1234 0.382319659324665 1895 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1279 0874-0590 65.2 µM 0.299249263592592 0.37366700586076 no 1235 0.382374931747797 1815 3523074
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.29824548972519 0.374064291897872 no 1236 0.382757902443697 1745 2374 Ca(2+)-ATPase inhibitor.
SGTC_1916 st067606 49.2 µM 0.296302223662673 0.374833801706434 no 1237 0.383499643961926 1882 19590279
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.295415921810521 0.375184932250916 no 1238 0.383838085959037 1861 5282309
SGTC_61 0978-8327 98.565 µM 0.294597217174447 0.375509374405477 no 1239 0.384150794126212 1895 6150059 YHR072W ERG7
SGTC_3219 9131112 49.47 µM 0.293177217723732 0.376072310702758 no 1240 0.384693348498344 1838 17612988 YMR079W SEC14
SGTC_2395 5646831 180.19 µM 0.293059343643812 0.376119051889159 no 1241 0.384738396077167 1843 6808628
SGTC_3116 9124943 49.47 µM 0.293021485550941 0.376134064329779 no 1242 0.384752864519629 1690 41905195 YPL160W CDC60
SGTC_2437 5741531 144.16 µM 0.292771111755592 0.376233353545207 no 1243 0.384848555335517 1911 2262990
SGTC_187 1488-2104 32.728 µM 0.291777237980617 0.37662756877125 no 1244 0.385228474894776 1870 2852859
SGTC_497 capsazepine 133 µM 0.291435301297797 0.376763226077647 no 1245 0.385359209576103 1699 2733484 A calcium channel blocker.
SGTC_1372 2752-0194 270 µM 0.290759905026408 0.377031222254023 no 1246 0.385617476110174 1767 823334
SGTC_2108 5365811 200 µM 0.290340654067109 0.377197610187497 no 1247 0.385777820095608 1863 780283
SGTC_2431 5490079 200 µM 0.290200764977179 0.377253132980563 no 1248 0.385831325508134 1747 5722345
SGTC_1330 1469-0054 61.8 µM 0.289578740182142 0.377500048951052 no 1249 0.386069266657863 1940 7102664
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.288450712869957 0.377947952935833 no 1250 0.386500876616476 1898 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2141 5621638 7.665 µM 0.288110636920792 0.378083018569748 no 1251 0.386631025305838 1916 2856238
SGTC_1193 1488-0126 41.5 µM 0.288086928174779 0.378092435365766 no 1252 0.386640099231807 1771 1384710
SGTC_390 dec-rvkr-cmk 16.7 µM 0.285792541178696 0.379004076968075 no 1253 0.387518510626312 1834 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_722 3534-0461 190 µM 0.285625341114064 0.379070537890923 no 1254 0.387582546135042 1764 658262
SGTC_3273 9137859 49.47 µM 0.283827377838915 0.379785441975601 no 1255 0.388271336236678 1902 2377234
SGTC_3122 9126309 49.47 µM 0.283262352308734 0.380010191781292 no 1256 0.388487867193661 1946 17591206
SGTC_738 1315-0003 72.4 µM 0.280790543688903 0.380993876886728 no 1257 0.389435528503389 1903 6251474
SGTC_3180 9109287 49.47 µM 0.28034899759659 0.381169676509195 no 1258 0.389604881313927 1813 18891271
SGTC_218 alverine citrate 93.75 µM 0.280031648123037 0.381296042948371 no 1259 0.389726612078864 1887 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1641 st009299 47.1 µM 0.278817858808829 0.381779482414758 no 1260 0.39019230419629 1876 4046054
SGTC_1241 0364-0022 50.8 µM 0.278244483663161 0.382007915869639 no 1261 0.39041234474781 1848 4563895
SGTC_346 4513-0042 7.16 µM 0.277800403151961 0.382184866399189 no 1262 0.390582790844317 1777 2827372
SGTC_2891 9063876 19.48 µM 0.273785323414215 0.383785847977767 no 1263 0.392124801524996 1990 6472478
SGTC_2629 bisabolol 100 µM 0.271126750123865 0.384847027782881 no 1264 0.393146774113567 1873 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1402 3909-7673 35.9 µM 0.270912599849956 0.384932544363463 no 1265 0.393229127008994 1798 5328014
SGTC_706 4262-0057 46.9 µM 0.270121574908566 0.38524847267 no 1266 0.393533362241732 1784 883298
SGTC_1287 0971-0001 34.6 µM 0.269374925462704 0.385546747689733 no 1267 0.393820589912252 1858 4665869
SGTC_1336 1486-0901 104 µM 0.268639848909003 0.385840465655136 no 1268 0.394103422060858 1871 5006114
SGTC_1518 st038567 90.8 µM 0.267581108852946 0.386263626358966 no 1269 0.394510886907387 1853 77966
SGTC_2862 9027634 71.43 µM 0.267533686622109 0.386282583402027 no 1270 0.394529140448776 1742 5012562
SGTC_2353 9059630 146.67 µM 0.267300370748571 0.386375855405862 no 1271 0.394618950666051 1913 4779114
SGTC_186 3455-3465 67.277 µM 0.26724029950288 0.386399870975003 no 1272 0.394642074781611 1854 755278
SGTC_2064 5220758 200 µM 0.267108065061212 0.386452737824023 no 1273 0.394692979054398 1849 788518
SGTC_2854 9024559 71.43 µM 0.266792638210988 0.386578852840583 no 1274 0.394814411368192 1770 3163529
SGTC_2023 5144124 124 µM 0.26585798185825 0.386952620561658 no 1275 0.395174293214236 1816 2830192
SGTC_3092 9117248 49.47 µM 0.264935942716244 0.38732144543002 no 1276 0.395529404540739 1923 17141857
SGTC_431 k089-0097 107 µM 0.264733782642787 0.387402325088537 no 1277 0.39560727545726 1844 5499420
SGTC_1618 st003135 44.5 µM 0.264108856265654 0.387652374844014 no 1278 0.395848019903246 1932 1270615
SGTC_1573 oleylamine 1.06 µM 0.263598582773436 0.387856583482552 no 1279 0.396044625348664 1793 5356789 An amine of the fatty acid oleic acid.
SGTC_2603 homopterocarpin 100 µM 0.263225658277134 0.388005845432331 no 1280 0.39618832774446 1823 101795 A weak amylase inhibitor.
SGTC_2274 7947094 46.08 µM 0.261594780722825 0.388658793591894 no 1281 0.396816934158347 1924 2971028
SGTC_1654 st012436 41.8 µM 0.261221951578331 0.388808106020108 no 1282 0.39696067537144 1944 4323132
SGTC_2200 6600604 21.907 µM 0.260938992961478 0.388921437628247 no 1283 0.397069777086625 1845 2904777
SGTC_1874 staurosporine 7.6 µM 0.259969123583115 0.389309964890505 no 1284 0.397443795366531 1932 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3194 9111903 49.47 µM 0.258917889396591 0.38973121168894 no 1285 0.397849297496381 1889 17087251
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.2588236833341 0.389768967937935 no 1286 0.397885641853759 1850 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3059 1327-0034 3 µM 0.258532565034463 0.389885649963497 no 1287 0.397997959837608 1794 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1305 1181-0477 144 µM 0.257008378548813 0.390496715152119 no 1288 0.398586152565688 1965 6252086
SGTC_2896 9052656 71.43 µM 0.256055881109357 0.390878720621112 no 1289 0.39895384414366 1895 6469436
SGTC_1771 st048882 4.1505 µM 0.255154605196157 0.391240280343411 no 1290 0.399301845318482 1769 4580403
SGTC_1238 0333-0287 48.8 µM 0.25501681473245 0.391295565250673 no 1291 0.399355056111851 1845 7226
SGTC_2290 7904846 200 µM 0.254647994990832 0.391443555563869 no 1292 0.39949749309862 1802 2962154
SGTC_13 0199-0087 65 µM 0.254491905084576 0.391506191961661 no 1293 0.399557778543702 1904 4589825
SGTC_878 0828-0289 13.7 µM 0.253974821616238 0.391713709423604 no 1294 0.399757504950455 1823 745350 YLR208W SEC13
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.252908244285041 0.392141848656359 no 1295 0.400169559260739 1854 688788
SGTC_2619 obliquin 87.91 µM 0.251000461758926 0.392907985005182 no 1296 0.40090687609147 1926 6708593 A bioactive alkalod. YER133W GLC7
SGTC_834 0312-0008 75.7 µM 0.250973850713725 0.392918674536729 no 1297 0.400917163190133 1856 6385573 YIL048W NEO1
SGTC_689 0833-0039 98 µM 0.249035411081335 0.393697553304374 no 1298 0.40166669501455 1961 5374726
SGTC_1382 3002-2117 298 µM 0.248821169683216 0.393783663183329 no 1299 0.401749557482932 1986 1497314
SGTC_3135 9127742 49.47 µM 0.248584476517644 0.393878803122591 no 1300 0.40184110879107 1830 3643468
SGTC_3168 9103419 49.47 µM 0.247938484156069 0.394138495032038 no 1301 0.402091001646744 1971 16649256
SGTC_3237 9133362 49.47 µM 0.247603638296984 0.394273123142682 no 1302 0.402220547709756 1948 43845137
SGTC_2458 5808907 16.39 µM 0.24728973868483 0.39439934107814 no 1303 0.402341999787048 1997 2731747
SGTC_2034 5197015 53.07 µM 0.247143353752685 0.394458205739105 no 1304 0.402398641354861 1976 780676
SGTC_475 α-linolenic acid 10 µM 0.245566393287777 0.395092489446658 no 1305 0.403008953490737 1967 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1971 st069429 63.5 µM 0.243669783784758 0.395855710359906 no 1306 0.403743288558657 1996 1246522 YGL099W LSG1
SGTC_1557 sumaresinolic acid 42.3 µM 0.243626158914244 0.39587327029944 no 1307 0.403760183372677 1839 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1473 k844-0725 134 µM 0.24311832703515 0.396077698986587 no 1308 0.403956867077367 1914 54682906
SGTC_1665 st014639 11.4 µM 0.241825375573954 0.396598307956854 no 1309 0.404457737755501 1919 981133 YIL048W NEO1
SGTC_402 epigallocatechin gallate 10 µM 0.241249313407687 0.396830319741669 no 1310 0.404680946384869 1846 65064 An antioxidant.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.240923280967908 0.396961647053106 no 1311 0.404807288957272 1842 260807
SGTC_3351 9150312 21.596 µM 0.240873693554289 0.396981622107227 no 1312 0.404826505710643 1974 4904905
SGTC_3336 9143619 71.43 µM 0.238340595558592 0.39800237595807 no 1313 0.405808468838637 1979 45595730
SGTC_955 1216-0110 33 µM 0.237864241831056 0.39819440883576 no 1314 0.405993195232879 1831 3619719
SGTC_2461 5755302 26.15 µM 0.237475289480948 0.398351225813877 no 1315 0.406144043555332 1994 2788904
SGTC_3267 9137951 49.47 µM 0.237335253358979 0.398407689299314 no 1316 0.406198357512824 1886 16643986
SGTC_2474 5321570 43.32 µM 0.236828077664745 0.398612203668427 no 1317 0.406395084138706 1984 2841384
SGTC_530 4358-1714 28 µM 0.235120081259675 0.39930114345566 no 1318 0.407057766470972 1943 1564641
SGTC_2796 7949634 45.45 µM 0.234756428600432 0.399447867476576 no 1319 0.407198893817409 1858 2971588
SGTC_1984 st072354 53.1 µM 0.23275984997146 0.400253685532585 no 1320 0.407973945864836 1916 5762938
SGTC_3130 9127414 49.47 µM 0.232564636258117 0.40033249653584 no 1321 0.408049745276422 2016 1494646
SGTC_1194 1488-0194 225 µM 0.230650857499606 0.401105335104403 no 1322 0.408793027058811 1901 1391452
SGTC_2077 5212015 200 µM 0.230516788089856 0.40115949070952 no 1323 0.408845109853893 1972 780900
SGTC_528 3492-0019 172 µM 0.229715307867646 0.401483277861896 no 1324 0.409156499509373 1967 2869262
SGTC_1090 efavirenz 20.7 µM 0.229090720502763 0.401735649612557 no 1325 0.409399202830191 1945 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1659 st012954 42.1 µM 0.228232414581302 0.402082524890803 no 1326 0.409732781580129 1963 24207262
SGTC_2902 5787006 60.46 µM 0.22549207154193 0.403190520616549 no 1327 0.410798246278779 1861 591003
SGTC_3091 9116372 49.47 µM 0.223772466666649 0.403886201661621 no 1328 0.411467177563468 1938 17169793
SGTC_2747 doxorubicin 7.63 µM 0.221275084522942 0.404897080292869 no 1329 0.412439124415652 2014 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1222 0366-0074 1.18 µM 0.22013549003165 0.405358571401813 no 1330 0.412882817810665 2024 286520
SGTC_1865 st057639 52.2 µM 0.219687155208659 0.405540165544345 no 1331 0.413057404479858 2005 688818
SGTC_493 zm226600 134 µM 0.219620735658243 0.405567069938993 no 1332 0.413083270470052 1962 5240098 A potassium channel opener. YCR052W RSC6
SGTC_323 4013-0906 34.3 µM 0.218466109641948 0.406034842481184 no 1333 0.413532980581553 2040 2910086
SGTC_618 k072-0232 33.2 µM 0.21688478854809 0.406675699191169 no 1334 0.41414906622102 1939 5872756 YGL099W LSG1
SGTC_125 0133-0007 11.75 µM 0.216514091823563 0.406825966449928 no 1335 0.414293520985774 2063 26541
SGTC_373 0844-0104 25.9 µM 0.21631520567532 0.406906593471977 no 1336 0.414371028613729 2038 5375804
SGTC_3204 9114183 49.47 µM 0.215722318930587 0.407146968918109 no 1337 0.414602101409433 1851 17027248
SGTC_1004 4084-0029 199 µM 0.214901715571678 0.407479725727557 no 1338 0.414921973654172 2039 716894 YLR208W SEC13
SGTC_1934 st074720 32.6 µM 0.214404440366561 0.407681404631353 no 1339 0.415115839633185 1823 17250992
SGTC_591 4299-0174 154 µM 0.212354002199306 0.408513254602318 no 1340 0.415915434148224 1962 5509088
SGTC_1142 3253-1408 9.78 µM 0.209354949950433 0.409730693123745 no 1341 0.417085579092774 2061 256655
SGTC_667 1498-1044 59 µM 0.208013145540877 0.410275669344274 no 1342 0.417609351598448 1939 6739982
SGTC_1311 1190-0148 100 µM 0.207572385299884 0.410454722759647 no 1343 0.417781434027168 2014 1961333
SGTC_2739 tacrine 100.86 µM 0.206446505614127 0.410912182159473 no 1344 0.418221073456851 1963 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1326 1431-2094 10.8 µM 0.206350190361543 0.41095132192156 no 1345 0.418258687896872 1871 616278
SGTC_2762 leflunomide 42.06 µM 0.206187364753612 0.411017491604599 no 1346 0.418322278632882 1908 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1952 st077036 64.1 µM 0.205130200563377 0.411447167469363 no 1347 0.418735200736732 2079 2937007
SGTC_3243 9134147 49.47 µM 0.204067272585562 0.411879293082758 no 1348 0.419150464429427 2066 24282180
SGTC_1812 st052057 4.327 µM 0.204022216372306 0.411897612722548 no 1349 0.419168068941404 1942 3645418
SGTC_1145 3546-0597 10.2 µM 0.203092874343455 0.412275521496562 no 1350 0.419531220562148 1955 875334
SGTC_1154 4088-0362 150 µM 0.202948521486778 0.412334228626311 no 1351 0.419587634342431 2010 6618304
SGTC_549 1661-1316 519 µM 0.202089063500551 0.412683803744832 no 1352 0.419923548770315 2065 2857282
SGTC_2203 7227154 166.4 µM 0.201427882320609 0.41295277909944 no 1353 0.420182007521331 2030 896304
SGTC_2470 5664817 21.68 µM 0.199761981965198 0.413630665572619 no 1354 0.420833367988955 2057 2859561
SGTC_2071 5230951 39.92 µM 0.199129895573214 0.413887941017523 no 1355 0.421080568103894 2054 1799272
SGTC_1314 1222-0010 41.1 µM 0.19895148764331 0.413960564334884 no 1356 0.42115034657577 1968 3526027
SGTC_903 1134-0042 114 µM 0.198631684391939 0.414090751858866 no 1357 0.421275433436598 1920 701009
SGTC_605 1315-0399 119 µM 0.197530442177531 0.414539124625837 no 1358 0.421706230647865 1996 24020461
SGTC_2152 5568786 200 µM 0.196557546322553 0.414935333624863 no 1359 0.422086897771712 1987 5399883
SGTC_1296 1068-0102 11.9 µM 0.195161977149269 0.415503826108227 no 1360 0.422633072252287 2045 767053
SGTC_2565 isoliquiritigenin 100 µM 0.195140516522524 0.415512569592216 no 1361 0.422641472316954 1800 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2757 clomiphene 4.22 µM 0.194231603504696 0.415882917092186 no 1362 0.422997269017673 2088 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2486 5283202 22.39 µM 0.19362511474598 0.416130079786352 no 1363 0.423234715804128 1888 1377751
SGTC_2103 5378138 10 µM 0.193407935870923 0.416218594882987 no 1364 0.42331975042391 2008 244142
SGTC_1047 2043-3044 82 µM 0.192848252926411 0.416446723154527 no 1365 0.423538906176634 1934 669592
SGTC_2688 kanamycin b 96.69 µM 0.192519414385847 0.416580771758904 no 1366 0.423667680933156 1966 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_332 4112-0506 40.9 µM 0.192191780037739 0.416714339131428 no 1367 0.423795992230104 1963 2790355
SGTC_1806 st050005 60.3 µM 0.191910046499087 0.41682920171587 no 1368 0.42390633387473 1911 5194765
SGTC_2341 7987486 176.74 µM 0.191860253214156 0.4168495031451 no 1369 0.423925836159874 2082 1258686
SGTC_71 0417-1750 47.813 µM 0.191732101975803 0.416901753244085 no 1370 0.423976029366699 2097 6811472
SGTC_2639 lactacystin 53 µM 0.191684423105019 0.416921193350708 no 1371 0.423994704143459 2038 3870 A proteasome inhibitor.
SGTC_3104 9120930 49.47 µM 0.189172928081273 0.417945491306726 no 1372 0.424978642407281 1994 17014836
SGTC_1959 st077091 55.8 µM 0.188623218528859 0.418169761523516 no 1373 0.425194066856806 1971 821356 YKL052C ASK1
SGTC_1371 2421-0008 32.7 µM 0.188446103819488 0.418242026361681 no 1374 0.425263480706055 1925 2827552
SGTC_911 3456-4043 236 µM 0.18818557121582 0.418348331675253 no 1375 0.425365591460096 2019 914281
SGTC_1460 k062-0059 9.15 µM 0.186837640884143 0.418898423788049 no 1376 0.425893966693145 1973 1373085
SGTC_1032 k061-1018 98.7 µM 0.18661870091548 0.41898778847366 no 1377 0.425979801563344 2113 4005393
SGTC_1149 3909-7961 23.3 µM 0.185980756164493 0.41924820208023 no 1378 0.426229926199536 1906 735261
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.185470514301136 0.419456511924937 no 1379 0.426430002601957 1930 688664
SGTC_890 0929-0006 47.2 µM 0.183776159056765 0.420148406057628 no 1380 0.427094529943721 1911 1378169
SGTC_2477 5967686 25.23 µM 0.182579202451202 0.420637335147763 no 1381 0.427564102032214 1961 776118
SGTC_3126 9127922 49.47 µM 0.182541396752253 0.420652779900327 no 1382 0.427578935073213 2004 45595682
SGTC_1766 st045414 44.774 µM 0.182016385231053 0.420867275339161 no 1383 0.427784933568871 2023 253960
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.181423541333125 0.421109512191563 no 1384 0.428017571081693 1952 6857784
SGTC_1086 cerivastatin 2.18 µM 0.179272627359111 0.421988628778379 no 1385 0.428861819427176 2099 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1318 1280-3875 124 µM 0.178630532819302 0.42225113974239 no 1386 0.429113909175255 2022 373245
SGTC_2328 6201408 200 µM 0.177530528546094 0.422700940620603 no 1387 0.429545843877145 1968 2890418
SGTC_1031 k035-0009 16 µM 0.176763320104161 0.423014718228577 no 1388 0.429847150809407 2096 5180959
SGTC_1186 1319-0216 26 µM 0.176467925076563 0.423135543730454 no 1389 0.429963172650815 2131 4565136
SGTC_2750 bromebric acid 70.15 µM 0.175792372441345 0.423411892348987 no 1390 0.4302285311154 2000 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1808 st050063 61.5 µM 0.175421578247252 0.423563589320903 no 1391 0.430374193241082 2092 4011993
SGTC_2011 4012611 177 µM 0.174924225727379 0.42376708081972 no 1392 0.430569587186626 1967 2049887
SGTC_1037 k284-1091 78.7 µM 0.174766352600746 0.423831678772669 no 1393 0.430631614060621 2056 3334711
SGTC_1844 rapamycin 4 nM 0.173516811255192 0.424343033639561 no 1394 0.431122607417459 1994 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1620 st003704 16.5 µM 0.17234016450302 0.424824674025636 no 1395 0.431585055000465 2101 2834414
SGTC_371 0195-0006 7.36 µM 0.171689544537901 0.425091042511041 no 1396 0.431840803003211 1994 3928593
SGTC_1884 5633444 25 µM 0.169959086495778 0.425799670598668 no 1397 0.432521156348721 2026 5724239
SGTC_847 0342-0274 5.54 µM 0.169401765417263 0.426027946499997 no 1398 0.432740317486275 2091 18097
SGTC_981 1488-1094 54.9 µM 0.168456669516987 0.426415109635508 no 1399 0.433112014593419 2039 3449522
SGTC_2656 pseudo-anisatin 100 µM 0.167735003400582 0.426710791447298 no 1400 0.433395878786346 2027 6708809 A neurotoxin.
SGTC_672 1441-0018 53.7 µM 0.166796245356704 0.427095482013088 no 1401 0.433765186536722 1989 251141
SGTC_894 0960-0238 55.9 µM 0.165950090035664 0.427442284645045 no 1402 0.434098113907257 2106 6741907 YDL195W SEC31
SGTC_1104 tacrolimus 29.8 µM 0.165170363792652 0.427761910509646 no 1403 0.434404945560181 2078 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_785 1270-0111 65.3 µM 0.163729697168441 0.428352594040998 no 1404 0.4349719690297 2165 6741994
SGTC_407 eburnamonine 100 µM 0.162262415237861 0.4289543550675 no 1405 0.43554960534809 1984 3195
SGTC_2295 7971645 200 µM 0.16012619278385 0.429830756625886 no 1406 0.436390834265455 2049 2978226 YKL099C UTP11
SGTC_3050 9093513 49.47 µM 0.158433928074917 0.43052526688103 no 1407 0.437057440325603 2079 25236664
SGTC_2760 etidronate 98.04 µM 0.158183057763204 0.43062824311791 no 1408 0.437156276808232 2025 3305 A chelator and antioxidant.
SGTC_941 3237-0776 460 µM 0.155729710211505 0.431635530936991 no 1409 0.438123038754463 2109 760008
SGTC_2385 9074692 200 µM 0.155565668637114 0.431702898550732 no 1410 0.438187693936818 1978 17046906
SGTC_1745 st081495 74 µM 0.155537591033004 0.43171442949259 no 1411 0.438198760581092 2036 13842402 YBL026W LSM2
SGTC_2691 st077356 60.2 µM 0.155203037383372 0.43185182883386 no 1412 0.438330626909935 2077 2839272
SGTC_3179 9107801 49.47 µM 0.154267377751452 0.432236142810869 no 1413 0.438699459076787 2054 4818259
SGTC_586 0957-0265 8.15 µM 0.154049579498949 0.432325610744692 no 1414 0.438785321667297 2146 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_917 harmaline 728.087 nM 0.153929646668655 0.43237487865734 no 1415 0.438832604009188 2057 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3105 9121040 49.47 µM 0.15347292351821 0.432562508266605 no 1416 0.439012670616921 2154 41448907
SGTC_1189 1431-2119 7.28 µM 0.152995409169471 0.432758695513832 no 1417 0.439200947810685 2122 3107275
SGTC_707 0865-0008 204 µM 0.152555843764414 0.432939306053595 no 1418 0.439374274429739 2065 723043
SGTC_1458 k015-0034 6.33 µM 0.152539626293906 0.432945969826401 no 1419 0.439380669421513 1949 3598957
SGTC_1983 st071813 46.9 µM 0.151084850112167 0.433543815980332 no 1420 0.439954391585116 2027 11838595
SGTC_2296 7971656 126.45 µM 0.150521171599444 0.433775502900525 no 1421 0.440176724251149 2031 666570
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.149991605593091 0.433993189402977 no 1422 0.440385619051863 2031 4330530
SGTC_2009 4012297 12.05 µM 0.149774220743875 0.434082554691134 no 1423 0.440471374387088 1994 45595307
SGTC_831 k061-1017 217 µM 0.149651950831247 0.434132820419825 no 1424 0.44051960941425 2102 1240153
SGTC_1893 st059353 36.1 µM 0.146879093142432 0.435273039489477 no 1425 0.441613727093394 1999 3112488
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.146440002906051 0.435453646181737 no 1426 0.441787024960516 2021 5282362
SGTC_2162 5663267 200 µM 0.146433571590951 0.435456291611815 no 1427 0.441789563321634 2134 6456493
SGTC_1925 st057770 10.1 µM 0.14570486652414 0.435756052763148 no 1428 0.442077189721301 1897 5989122
SGTC_140 0062-0056 502.533 µM 0.144939659280184 0.436070869232434 no 1429 0.442379256727361 2108 3758964
SGTC_2927 9011802 47.9 µM 0.144678146125587 0.4361784685307 no 1430 0.442482497229793 1991 43912568
SGTC_1715 st032160 10.2275 µM 0.14404987239731 0.436436990351635 no 1431 0.442730543899227 2123 5289825
SGTC_2396 5342950 42.78 µM 0.14259278091129 0.437036658100486 no 1432 0.443305899608135 2027 1886677
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.141543666970244 0.437468511877781 no 1433 0.443720233003667 2089 6708784 An antioxidant flavonoid
SGTC_2224 6650123 117.647 µM 0.141170397297706 0.437622181362415 no 1434 0.443867665688402 2070 2908370
SGTC_296 1222-0039 74.9 µM 0.141085568869715 0.437657105257516 no 1435 0.443901171993569 2041 5984176
SGTC_2188 6126565 140.678 µM 0.141060230713932 0.437667537079814 no 1436 0.443911180366928 2130 874518
SGTC_2641 levomentholum 100 µM 0.141013032841416 0.437686968752344 no 1437 0.4439298232528 2122 16666
SGTC_2806 7952793 58.44 µM 0.139225663067437 0.438422950755875 no 1438 0.44463591489837 2088 2972490
SGTC_1160 4092-0570 10.5 µM 0.137725597107163 0.439040794699965 no 1439 0.445228644306275 1985 4994975
SGTC_220 paclitaxel 373.376 µM 0.137471390497201 0.439145511533428 no 1440 0.445329102549697 2161 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2428 5615643 7.78 µM 0.136133532664451 0.439696693250462 no 1441 0.445857859522897 2119 2253075
SGTC_629 3448-6466 76.7 µM 0.134088017215249 0.440539647268568 no 1442 0.4466664874749 2132 573744
SGTC_3242 9133940 49.47 µM 0.132230794673939 0.441305239615283 no 1443 0.447400872174533 2142 17248444
SGTC_2240 6690706 185.951 µM 0.130665338323776 0.441950729345231 no 1444 0.448020026606245 1981 805876
SGTC_2133 5320837 200 µM 0.130633088183696 0.441964028777493 no 1445 0.448032783212118 2158 2841355
SGTC_1249 0481-0015 10.2 µM 0.130540881510725 0.442002053667806 no 1446 0.448069256038077 2097 4227577
SGTC_3036 9090181 49.47 µM 0.129856345046794 0.442284364718547 no 1447 0.448340041681 2130 25236586
SGTC_776 4476-4378 112 µM 0.129332237030825 0.442500532973942 no 1448 0.448547382086958 2020 2892008
SGTC_1453 4237-0541 195 µM 0.128683163825862 0.442768266822023 no 1449 0.448804178977445 2189 739892
SGTC_1359 1582-0056 520 nM 0.127903509648726 0.443089898084134 no 1450 0.449112666781798 2127 3661189
SGTC_739 1486-1183 203 µM 0.127297826155482 0.443339786997884 no 1451 0.449352340393802 2195 4346692
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.125618456010362 0.444032768055289 no 1452 0.450016976451323 2108 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_708 3448-5400 146 µM 0.125469801212455 0.4440941177575 no 1453 0.450075815611771 2198 3462195
SGTC_3225 9130819 49.47 µM 0.125292603880563 0.444167248688031 no 1454 0.450145953646394 2158 4547121
SGTC_2955 9076254 12.21 µM 0.125240256972815 0.44418885309092 no 1455 0.450166673834465 2166 16459619
SGTC_1177 0983-0204 23.6 µM 0.124421533303578 0.444526774934866 no 1456 0.450490762354944 2193 766818
SGTC_1712 st032288 53.4 µM 0.124184421873062 0.444624648379856 no 1457 0.450584628150096 2116 2883011
SGTC_1451 4152-0210 104 µM 0.12372699448981 0.44481347206709 no 1458 0.45076571868452 2187 659563
SGTC_1351 1496-0003 46.5 µM 0.122958550526059 0.445130709979559 no 1459 0.451069960358789 2175 3891978
SGTC_2192 5915882 198.485 µM 0.121642654336943 0.445674034947619 no 1460 0.451591015514986 2176 2876149
SGTC_2359 9039622 200 µM 0.121400841506421 0.445773889019548 no 1461 0.45168677519274 2127 6463596
SGTC_1088 bifonazole 369 nM 0.120485003544364 0.446152105830208 no 1462 0.452049479270426 2172 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1575 cyproterone acetate 48 µM 0.119402091650906 0.446599382943956 no 1463 0.452478402126838 2064 9880 An androgen receptor antagonist and liver toxin.
SGTC_2868 9035608 32.47 µM 0.119259354150849 0.446658343159423 no 1464 0.452534942154113 2205 6462614
SGTC_2588 indole-3-carbinol 100 µM 0.119123617894052 0.446714412483033 no 1465 0.452588709798215 2192 3712 Induces cell cycle arrest.
SGTC_1092 toremifene 6.32 µM 0.11895051331241 0.446785919291853 no 1466 0.452657280988791 2212 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1485 3909-9022 254 µM 0.118289422242608 0.447059021626164 no 1467 0.4529191691918 2174 714516
SGTC_1558 st069300 45.6 µM 0.117555542271492 0.447362223073595 no 1468 0.453209916367325 2202 24208000
SGTC_1709 st033179 39.1045 µM 0.117097210659632 0.447551597733006 no 1469 0.453391510051055 2203 573381
SGTC_2490 carminic acid 95.39 µM 0.116691395926618 0.447719283312047 no 1470 0.45355230437444 2172 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_573 3702-0553 84.7 µM 0.115688993204121 0.448133523341858 no 1471 0.453949514913178 2176 1222756
SGTC_2512 diallyl trisulfide 49.23 µM 0.115496208885603 0.448213197403948 no 1472 0.454025912620278 2206 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_146 3448-8650 53.125 µM 0.11505700394979 0.448394720177895 no 1473 0.454199969691192 2090 2891488 YIL048W NEO1
SGTC_487 nimodipine 119 µM 0.114460880436462 0.448641114454629 no 1474 0.454436227714644 2216 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2519 cryptotanshinone 88.04 µM 0.11401303217553 0.448826235520976 no 1475 0.454613731314434 2174 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1606 st000094 49.2 µM 0.112191277274021 0.449579384484985 no 1476 0.455335872616283 2223 1242210
SGTC_8 0354-0001 70 µM 0.111621723617226 0.449814886466745 no 1477 0.455561673353552 2133 4993152
SGTC_101 0490-5701 117.494 µM 0.11016639435951 0.450416723603038 no 1478 0.456138706713732 2203 4661669
SGTC_3048 9093155 49.47 µM 0.109653508240867 0.450628849872287 no 1479 0.456342086517772 2234 25236002
SGTC_1204 4049-0315 18.3 µM 0.109558859829734 0.45066799736553 no 1480 0.456379619639882 2162 588402
SGTC_2391 6285546 200 µM 0.10940628123479 0.450731106350274 no 1481 0.456440125976024 2156 846083
SGTC_158 k038-0087 26.446 µM 0.107893649314773 0.451356822609116 no 1482 0.457040027413624 2099 X158
SGTC_2784 7567673 72.73 µM 0.107725202990258 0.45142650972877 no 1483 0.457106838376342 2224 3471247
SGTC_4 0960-0234 25.671 µM 0.107557416366063 0.45149592541514 no 1484 0.457173388886988 2105 6821112
SGTC_2952 9073731 13.78 µM 0.107495980632744 0.451521342613177 no 1485 0.457197756919076 2123 16457353
SGTC_1526 st051518 75 µM 0.106759247867281 0.451826159222434 no 1486 0.457489989066043 2050 673993
SGTC_2363 9053361 176 µM 0.106490645050341 0.45193729831625 no 1487 0.457596538686427 2217 6469797 YMR079W SEC14
SGTC_2699 st077704 54.6 µM 0.105827955518683 0.452211513744409 no 1488 0.457859428018402 2134 645852
SGTC_86 0417-1630 471.922 µM 0.10565340719298 0.452283744191446 no 1489 0.457928674515553 2218 3634867
SGTC_772 k072-0172 35.3 µM 0.104191755877733 0.452888656938242 no 1490 0.458508588110434 2017 5861980
SGTC_1295 1013-0063 9.78 µM 0.103266227852543 0.453271748630095 no 1491 0.45887583927728 2244 6826038
SGTC_2954 9074818 52.69 µM 0.102207824965327 0.453709892757837 no 1492 0.459295858430448 2176 16648742
SGTC_1386 3228-0095 33.8 µM 0.10181889701755 0.453870910374246 no 1493 0.459450212975958 2196 870181
SGTC_524 r073-0010 27.8 µM 0.101589009938774 0.453966088046727 no 1494 0.459541451556881 2089 2772106
SGTC_583 1488-1091 88.9 µM 0.101201587352622 0.454126494428564 no 1495 0.459695218332196 2247 4303273
SGTC_1711 st032263 62.8 µM 0.101052129544564 0.454188377143997 no 1496 0.459754539267116 2136 3958979
SGTC_789 1309-1135 70.6 µM 0.100804952565958 0.454290722732117 no 1497 0.459852647645718 2235 3092424
SGTC_3043 9092303 49.47 µM 0.0985408605317613 0.455228328359716 no 1498 0.460751413905859 2154 25236084
SGTC_3223 9129970 49.47 µM 0.0983795427742776 0.455295142839132 no 1499 0.460815459185586 2195 17248386
SGTC_172 1112-0046 2.638 µM 0.0975851835639124 0.455624168407067 no 1500 0.461130845074724 2136 2802135 YIL048W NEO1
SGTC_1200 1643-0193 18.4 µM 0.0964571311393538 0.456091462787383 no 1501 0.461578759754988 2245 5403974
SGTC_1025 k007-0731 70 µM 0.0961881902429831 0.456202880226141 no 1502 0.461685555071822 2162 6256118
SGTC_2813 7971799 71.43 µM 0.0956244166004855 0.456436452803523 no 1503 0.461909436208683 2164 2234054
SGTC_2112 5488546 200 µM 0.0953925840824771 0.456532505864097 no 1504 0.462001503131413 2215 600757
SGTC_799 1310-0557 151 µM 0.0941119354487504 0.45706315099304 no 1505 0.462510119673582 2143 5354492
SGTC_1343 1487-0095 224 µM 0.0933965737782976 0.457359599166198 no 1506 0.462794256175469 2244 4560101 YGL055W OLE1
SGTC_2302 7771753 200 µM 0.0931777286915571 0.457450294020097 no 1507 0.462881183666224 2136 2203047
SGTC_2967 9089538 49.85 µM 0.0930277367248961 0.457512455706496 no 1508 0.462940763022539 2256 728216
SGTC_2912 7964298 10.93 µM 0.0906594486051893 0.458494090280081 no 1509 0.46388159660588 2156 2975850
SGTC_872 0588-0139 234 µM 0.089918201145971 0.458801383129534 no 1510 0.464176108659322 2262 2047100
SGTC_567 1080-0542 68.4 µM 0.0898215244731892 0.458841463399784 no 1511 0.464214521634999 2253 5950415
SGTC_454 lyso-paf C-16 6.67 µM 0.0896130676994071 0.458927886951394 no 1512 0.464297349833759 2152 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_652 0437-0092 114 µM 0.0886442173655252 0.45932958550439 no 1513 0.464682333002701 2224 3091274
SGTC_634 1611-4317 11.2 µM 0.0864776492166221 0.460228023841283 no 1514 0.465543361421515 2268 2843522
SGTC_1027 k015-0025 8.67 µM 0.0861411671898851 0.460367575454015 no 1515 0.465677099271502 2266 3598955
SGTC_2242 6630449 61.2675 µM 0.08406330117554 0.461229451283295 no 1516 0.466503051373936 2184 691249 YDR170C SEC7
SGTC_2592 piperlongumine 83.33 µM 0.0837683454591658 0.46135181050637 no 1517 0.466620308098915 2159 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_380 3970-0968 6 µM 0.0804203686274684 0.462740936543787 no 1518 0.467951463774221 2225 2891601
SGTC_2803 7707263 71.43 µM 0.0798248018549465 0.462988094276279 no 1519 0.468188299118258 2199 2199229
SGTC_609 0986-0026 86.3 µM 0.0793721068937812 0.463175970364856 no 1520 0.468368327051782 2227 2848610
SGTC_2027 5150920 200 µM 0.0780671774653116 0.463717584032735 no 1521 0.468887308037309 2239 786715
SGTC_2885 9057732 51.95 µM 0.0779026311944331 0.463785884099472 no 1522 0.468952753191783 2198 6471414
SGTC_206 4546-0025 72.014 µM 0.0765041796313714 0.464366397959579 no 1523 0.469508994428985 2167 6620745 YIL048W NEO1
SGTC_3221 9128209 49.47 µM 0.0762501241547659 0.464471867585578 no 1524 0.469610052709423 2215 16460723
SGTC_2818 7996756 12.99 µM 0.0747940185219955 0.465076409145547 no 1525 0.470189300508346 2252 2241621
SGTC_782 0083-0095 30.5 µM 0.0746835842408533 0.4651222622249 no 1526 0.470233234535476 2308 3591729 An indicator and reagent.
SGTC_561 1550-0330 72.9 µM 0.0733533143409994 0.46567463572555 no 1527 0.470762483609756 2208 6812934
SGTC_1978 st071761 42 µM 0.0732282954090114 0.465726551272827 no 1528 0.47081222517353 2116 5147680
SGTC_729 4092-0585 94.1 µM 0.0730828747558831 0.465786939602877 no 1529 0.470870084588863 2219 2169061
SGTC_1405 3909-7894 12 µM 0.0730459739088446 0.465802263414962 no 1530 0.470884766655134 2273 7104060
SGTC_2321 7390090 138.78 µM 0.069579700928894 0.467241925303714 no 1531 0.472264097043902 2180 649046
SGTC_2824 7998404 51.95 µM 0.0688213773704271 0.467556940847887 no 1532 0.472565900874374 2242 837851
SGTC_3308 9128332 17.569 µM 0.0687002275139409 0.467607269653972 no 1533 0.472614118551775 2273 17332805 YDL196W YDL196W
SGTC_2651 TUB2.036 5 µM 0.067481178913782 0.468113722881363 no 1534 0.473099322459456 2278 15992207 YFL037W TUB2
SGTC_997 3996-0078 137 µM 0.0673893577992401 0.468151872025119 no 1535 0.47313587058813 2235 735687
SGTC_11 0438-0307 1.3 µM 0.0667512493680831 0.46841699656038 no 1536 0.473389867081373 2298 4011476
SGTC_3004 9076122 71.4286 µM 0.0661739807594048 0.468656855128331 no 1537 0.473619655851883 2279 44782551
SGTC_2624 nerol 100 µM 0.0655984603977066 0.468895998615065 no 1538 0.473848757449857 2272 637566 A natural product oil.
SGTC_117 lucigenin 22.078 µM 0.0648271950267057 0.469216496761004 no 1539 0.474155794243889 2084 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2129 girgensonine 121.053 µM 0.0646436175194208 0.469292785060393 no 1540 0.474228877778037 2240 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2492 derrusnin 100 µM 0.064188362855357 0.469481977606564 no 1541 0.474410121691434 2246 1715307 Part of coumarin class of compounds.
SGTC_1888 azatryptophan 97.5 µM 0.0641432024209686 0.469500745539296 no 1542 0.474428101047257 2175 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2781 5567276 71.43 µM 0.0639553548472808 0.469578812623729 no 1543 0.474502887829845 2265 2853274
SGTC_992 3909-8734 162 µM 0.0630116538610557 0.469971020495772 no 1544 0.474878612162349 2251 4288319
SGTC_3241 9133421 49.47 µM 0.0618983165082646 0.470433767707441 no 1545 0.475321904080443 2288 17018221
SGTC_508 roscovitine 141 µM 0.0617292316166876 0.470504049610297 no 1546 0.475389230444556 2306 160355 A CDKinase inhibitor.
SGTC_378 3970-0959 8.33 µM 0.0613900700073993 0.470645028446591 no 1547 0.475524280215488 2248 6615653
SGTC_798 1287-0182 476 µM 0.0612838436014378 0.470689184187053 no 1548 0.475566578776921 2298 1649755
SGTC_949 1165-0505 146 µM 0.0598415531865527 0.47128874476923 no 1549 0.476140915100938 2234 6244267
SGTC_1891 st059073 26.2 µM 0.0594641711227223 0.471445633409721 no 1550 0.476291201129448 2317 688754
SGTC_482 fipronil 114 µM 0.0589099715007497 0.471676038249154 no 1551 0.476511907868932 2307 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1109 tnp00067 928.257 nM 0.0587251235969226 0.471752889658656 no 1552 0.476585524065153 2186 676295
SGTC_78 0336-0123 156.75 µM 0.0584839247523171 0.471853170825309 no 1553 0.476681583382906 2120 6765896
SGTC_1071 trifluoperazine 6.31 µM 0.0580435597847386 0.472036262174358 no 1554 0.476856965651183 2270 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3061 glucosamine 200 µM 0.0579958454523885 0.472056100805231 no 1555 0.476875968903614 2295 91431 and experimental redox chemotherapeutic
SGTC_227 fluconazole 33.516 µM 0.0577588225443491 0.472154651046523 no 1556 0.476970369120099 2242 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1392 3455-1037 33.9 µM 0.0573556841004613 0.472322273318041 no 1557 0.477130931909537 2275 981132
SGTC_626 0214-0009 33 µM 0.0572497111272952 0.47236633698714 no 1558 0.477173139655516 2273 3437874
SGTC_351 caspofungin 25 nM 0.057120856005158 0.472419915532424 no 1559 0.477224461427989 2236 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0560408055506078 0.472869024947839 no 1560 0.477654650046127 2276 17037758
SGTC_1781 st038725 66.3 µM 0.0556016182598299 0.473051658856911 no 1561 0.477829587658127 2241 4270275 YIL048W NEO1
SGTC_1431 4049-0260 9.09 µM 0.0552218642631314 0.473209582286769 no 1562 0.47798085517379 2295 3854841
SGTC_3286 9117135 37.221 µM 0.0547655009918333 0.473399369802831 no 1563 0.478162642677974 2254 3438150
SGTC_1170 0310-0127 64.8 µM 0.0546681540875811 0.473439854183533 no 1564 0.478201420381572 2277 774975
SGTC_598 3937-0236 20.2 µM 0.054087630013513 0.473681286727185 no 1565 0.478432673820371 2277 1379313
SGTC_909 3448-9333 149 µM 0.0536099924671615 0.473879937331994 no 1566 0.478622947562573 2287 3344074
SGTC_467 ro 31-8220 72.8 µM 0.0523798336247714 0.474391593141615 no 1567 0.479113021245783 2311 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0519834426753917 0.474556471728837 no 1568 0.479270943202906 2310 65057 A dermal irritant. YDR527W RBA50
SGTC_1789 tunicamycin 25 nM 0.0516130981626472 0.474710520254061 no 1569 0.479418491213539 2287 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_99 0109-0120 622.8 µM 0.0511696801815818 0.474894969395164 no 1570 0.479595155946134 2304 759414
SGTC_2838 9002687 71.43 µM 0.0501139103728769 0.475334160889402 no 1571 0.480015807396151 2278 6457060
SGTC_1000 4048-0884 8.67 µM 0.0496004332655127 0.475547773978688 no 1572 0.480220400681358 2261 13040088
SGTC_1835 st008666 49.2 µM 0.0494198101230494 0.475622917206204 no 1573 0.480292370627288 2241 690455
SGTC_1706 st031321 9.9705 µM 0.0480724598434335 0.476183471936809 no 1574 0.48082924734133 2316 6103185
SGTC_2717 st081029 62.2815 µM 0.046071580153144 0.477016009204631 no 1575 0.481626598849605 2317 5292846
SGTC_339 3091-4833 71.4 µM 0.0460409517490629 0.47702875403205 no 1576 0.481638804862533 2279 3240077
SGTC_606 k015-0008 38.6 µM 0.0457632664659184 0.477144303108355 no 1577 0.481749468616372 2311 1970475
SGTC_2446 5162541 200 µM 0.0454505091194854 0.477274448504952 no 1578 0.481874111050037 2321 1549321
SGTC_3064 1327-0027 10 µM 0.0450473571043403 0.477442212738994 no 1579 0.48203478086601 2277 16000455 YPR107C YTH1
SGTC_2940 9060638 45.86 µM 0.0449888922985429 0.477466542116221 no 1580 0.482058081326264 2257 4027022
SGTC_2206 7254556 146.969 µM 0.0432867764052937 0.478174892203431 no 1581 0.482736466121341 2321 4398905
SGTC_2673 kobusone 100 µM 0.0431263693637547 0.478241650555658 no 1582 0.482800399568623 2334 6710676 An epoxy ketone and protein crosslinker.
SGTC_1649 st011737 51.3 µM 0.0430471258659636 0.478274630413922 no 1583 0.482831983819147 2265 1761035
SGTC_1801 st050089 28.441 µM 0.0428934936833528 0.478338570059642 no 1584 0.482893217633744 2322 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3355 9151058 44.0485 µM 0.0424321835258805 0.47853056447939 no 1585 0.483077086350784 2337 17015728
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0423571780693823 0.478561781756173 no 1586 0.483106982320412 2319 641818 YHR062C RPP1
SGTC_432 NS 1619 61.3 µM 0.0421977521414546 0.478628135276318 no 1587 0.483170527248608 2220 4552 A K+/calcium channel activator.
SGTC_3070 9117005 49.47 µM 0.041808227327899 0.478790259088661 no 1588 0.483325788144988 2340 8779016
SGTC_854 0422-0053 192 µM 0.0416013971698017 0.478876345132144 no 1589 0.48340822971363 2313 3596728
SGTC_2728 chlorpromazine 9.18 µM 0.0413772786361848 0.478969627988322 no 1590 0.483497563151493 2340 2726 A thorazine and dopamine antagonist.
SGTC_2058 5236698 133 µM 0.0409549369655017 0.479145418617737 no 1591 0.483665910394308 2311 766665
SGTC_1512 0259-0544 12.2 µM 0.0405497844607721 0.479314058439677 no 1592 0.483827408697109 2252 18476
SGTC_2832 7992762 51.95 µM 0.0385817559466115 0.480133278597675 no 1593 0.484611924053704 2292 2985177
SGTC_2312 7706453 155.7 µM 0.0372234386883553 0.480698746838656 no 1594 0.485153425094831 2303 976098
SGTC_2378 9074213 121.43 µM 0.0365055725666826 0.480997610670227 no 1595 0.485439617703508 2328 657714
SGTC_2551 apiole 73.87 µM 0.0361254442931197 0.481155870966351 no 1596 0.485591166977126 2336 10659 A possible DNA adduct former.
SGTC_3327 9140648 26.9345 µM 0.0346212825245055 0.481782133426209 no 1597 0.486190865335565 2331 8029710
SGTC_2171 5739187 198.077 µM 0.0344569353244171 0.481850562649652 no 1598 0.486256391286021 2341 2262761
SGTC_425 3825-7017 13.1 µM 0.0339020227803671 0.482081615456234 no 1599 0.486477640085685 2286 3397440
SGTC_566 0958-0068 16.5 µM 0.0334838274543558 0.482255746342342 no 1600 0.486644381211254 2336 6815365
SGTC_1291 0993-0025 5.79 µM 0.0325732183239274 0.482634923352117 no 1601 0.48700746358749 2342 4353356
SGTC_1982 st072467 71.9 µM 0.0323685025180566 0.482720169046308 no 1602 0.487089090334574 2293 3163533
SGTC_1101 ebselen 5.29 µM 0.0307688151317636 0.483386321657737 no 1603 0.487726955279417 2361 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_188 3229-0966 278.469 µM 0.0305401249460357 0.483481558199894 no 1604 0.487818146607264 2360 5722370
SGTC_2614 arthonioic acid 13.39 µM 0.0304713022170931 0.48351021916299 no 1605 0.487845590131263 2348 6710684
SGTC_1201 1889-3372 45.9 µM 0.0303704063619761 0.48355223701119 no 1606 0.487885823133081 2276 5392199
SGTC_1846 st056244 14.8 µM 0.030005363787813 0.483704259679222 no 1607 0.48803138770703 2293 5393182
SGTC_3071 9117417 49.47 µM 0.0297451315825455 0.483812635319232 no 1608 0.48813515901628 2348 45595590 YGL055W OLE1
SGTC_1594 piperine 70.1 µM 0.0291284243620733 0.484069472394918 no 1609 0.48838108302466 2363 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_26 0302-0163 425.158 µM 0.0290222127718176 0.484113706492802 no 1610 0.488423437412225 2339 3100915
SGTC_839 0122-0028 230 µM 0.0288583732652662 0.484181941357332 no 1611 0.488488772552371 2339 759448
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0285415822729135 0.484313877822854 no 1612 0.488615101834025 2362 88881 An O-methylated flavonoid and antioxidant.
SGTC_855 0428-0020 25 µM 0.0277228490475566 0.4846548700842 no 1613 0.488941599900504 2306 6812414
SGTC_2844 9010103 25.97 µM 0.0273340397843476 0.484816808278494 no 1614 0.489096653591475 2317 2480525
SGTC_1610 st001799 48.1 µM 0.0268394812248447 0.485022794434713 no 1615 0.48929388154337 2348 621897
SGTC_711 k292-0785 179 µM 0.0258880271162901 0.485419091104932 no 1616 0.489673324912322 2356 4146315
SGTC_1411 3909-8223 150 µM 0.0257144218049513 0.485491402207822 no 1617 0.489742560362065 2358 X1411
SGTC_2690 usnic acid 100 µM 0.0252870900094022 0.485669398982241 no 1618 0.489912985659953 2350 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_62 0180-0423 3.232 µM 0.0246118859527116 0.485950647947295 no 1619 0.490182269276486 2336 30102 YGL099W LSG1
SGTC_3146 9095609 49.47 µM 0.024556341946089 0.485973784516989 no 1620 0.49020442143399 2350 17173999
SGTC_2570 licareol 100 µM 0.0232506795723006 0.486517664881107 no 1621 0.490725156532349 2317 443158
SGTC_2630 antimycin a 100 µM 0.0229787899974483 0.486630925067669 no 1622 0.490833595806092 2362 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1680 diphenhydramine 100 µM 0.0227663462324979 0.486719422850781 no 1623 0.490918326439479 2302 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_972 1319-0219 195 µM 0.0227457304670102 0.486728010803238 no 1624 0.490926548810774 2328 23903702
SGTC_2521 angolensin 13.4 µM 0.0222005740453525 0.486955109972704 no 1625 0.491143979841217 2321 821428 A flavenoid.
SGTC_2041 5107442 45.335 µM 0.0219466920135237 0.487060872623195 no 1626 0.491245239445539 2368 793005
SGTC_3278 9139605 49.47 µM 0.0200850874044366 0.487836410666199 no 1627 0.49198774813717 2349 7958859
SGTC_2790 5423970 71.43 µM 0.0189004926788791 0.488329932865541 no 1628 0.49246024325547 2349 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_16 erodoxin 22.806 µM 0.0184550126484505 0.48851553204565 no 1629 0.492637933076213 2372 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_754 3474-0146 171 µM 0.018060691606709 0.48867981906642 no 1630 0.492795218193181 2379 24762078
SGTC_1475 4092-1048 11.7 µM 0.0180512463218763 0.488683754304142 no 1631 0.492798985702463 2341 2881759
SGTC_151 3013-0144 2.285 µM 0.0177931338433428 0.48879129346205 no 1632 0.492901941146739 2364 906558 YHR107C CDC12
SGTC_3337 9144342 33.5465 µM 0.01642072991993 0.489363100941943 no 1633 0.493449370946885 2381 17682949
SGTC_219 mitoxanthrone 164.414 µM 0.016119508331061 0.489488606870927 no 1634 0.493569525069542 2354 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1258 0671-0043 57.1 µM 0.0160053798004748 0.489536159536085 no 1635 0.493615049892639 2355 4298767
SGTC_732 3970-1727 52.7 µM 0.0157267434445759 0.489652256470146 no 1636 0.493726195725147 2368 1275699
SGTC_319 1348-1596 45.5 µM 0.0153558687435465 0.489806786894139 no 1637 0.493874135456089 2377 5380505
SGTC_2177 5811945 192 µM 0.0138843047378027 0.490419950633913 no 1638 0.494461141764585 2369 5343475
SGTC_3284 9108171 64.8615 µM 0.0133649316981701 0.490636365807376 no 1639 0.494668322396681 2357 8687505
SGTC_1497 4476-2978 41.3 µM 0.0131360935677804 0.490731720198593 no 1640 0.494759607587962 2355 1528379
SGTC_369 0957-0393 4.5 µM 0.011859297744736 0.491263756875053 no 1641 0.495268935612485 2374 6997992
SGTC_1205 4161-2785 76 µM 0.0105452870669393 0.491811317080452 no 1642 0.495793117099894 2354 3498106
SGTC_2711 st079103 59.1 µM 0.0104412070370001 0.491854688848998 no 1643 0.495834636738474 2375 54693780
SGTC_777 1315-0167 517 µM 0.0100047295186042 0.492036576867743 no 1644 0.496008756974814 2344 4221767
SGTC_3147 9097027 49.47 µM 0.00962566655178153 0.492194540556746 no 1645 0.496159973934155 2376 25236841
SGTC_1257 0669-0121 16 µM 0.00926831439016113 0.492343458007739 no 1646 0.496302530458244 2374 4307855
SGTC_2397 5161689 200 µM 0.00879869823873949 0.492539160248832 no 1647 0.496489872550774 2376 2259942
SGTC_1430 4049-0248 69.1 µM 0.00555792419556759 0.493889728252727 no 1648 0.497782720462615 2387 22774488
SGTC_424 splitomicin 100 mM 0.00480485206964454 0.494203575946085 no 1649 0.498083148733945 2381 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_445 e6 berbamine 66 µM 0.00340550092008771 0.494786773994996 no 1650 0.498641404323069 2392 6610268 A calcium/calmodulin antagonist.
SGTC_273 hydroxyurea 18.1 mM 0.0029012021713822 0.494996949946609 no 1651 0.498842589413493 2401 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2897 9048598 12.99 µM 0.00162207087011589 0.495530057975732 no 1652 0.499352887631874 2397 6467404
SGTC_2323 6148992 148.28 µM 0.00158906656249595 0.495543813406262 no 1653 0.499366054428648 2400 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_477 mead ethanolamide 10 µM 0.00148034640363917 0.495589125486231 no 1654 0.499409427445647 2403 16061185
SGTC_2789 5281112 71.43 µM 0.000811221476923295 0.495868002709366 no 1655 0.499676369489581 2403 765948
SGTC_93 0109-0045 59.227 µM 0.000508093451306228 0.495994340779936 no 1656 0.4997973000486 2399 88733
SGTC_1562 morin hydrate 59.1 µM 0.000456183924181225 0.496015975737004 no 1657 0.499818008951317 2405 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_68 0986-0284 82.829 µM -0.000531209544512268 0.496427505730318 no 1658 0.499788078062908 2406 423278 YIL048W NEO1
SGTC_624 k048-0052 28 µM -0.00101403571024376 0.496628741456953 no 1659 0.499595458350676 2405 6835531
SGTC_472 calcifediol 10 µM -0.00108885891168896 0.496659926881585 no 1660 0.499565608228572 2411 5283731 A vitamin D metabolite.
SGTC_3123 9126162 49.47 µM -0.00375685850000564 0.4977719294279 no 1661 0.498501233828457 2420 25239884
SGTC_2999 9069765 71.4286 µM -0.00409119057278939 0.497911277967645 no 1662 0.498367855656431 2412 2097066
SGTC_954 1189-0853 2.85 µM -0.00432367623035503 0.498008177398164 no 1663 0.498275108119185 2406 2828194
SGTC_2529 gangaleoidin 93.61 µM -0.0046104658816165 0.498127710756356 no 1664 0.498160696743637 2416 4565183
SGTC_3143 9086658 49.47 µM -0.00504157658704276 0.498307397156728 no 1665 0.497988710459874 2431 25236626
SGTC_2975 9084847 53.72 µM -0.00538385834136917 0.498450060008208 no 1666 0.497852161652123 2440 27211724
SGTC_2256 7954252 200 µM -0.00550836492421425 0.49850195433523 no 1667 0.497802491448688 2430 2972920
SGTC_1920 st075728 45.7 µM -0.00561208781699107 0.498545186042413 no 1668 0.497761112640973 2415 3400306
SGTC_2098 5376439 882.5 nM -0.00583901525538401 0.498639769469584 no 1669 0.497670583175287 2428 2844116
SGTC_714 4296-0578 26.1 µM -0.00628592692010915 0.498826042609512 no 1670 0.497492294494509 2419 1589775
SGTC_2116 5511452 16.8835 µM -0.00646437548118538 0.498900420186515 no 1671 0.497421105265384 2419 870744
SGTC_510 ag-490 170 µM -0.00688964910760028 0.499077674899823 no 1672 0.497251449418229 2417 5328779
SGTC_3017 9080681 49.47 µM -0.00692642387154051 0.499093002688062 no 1673 0.497236778760095 2426 16451914
SGTC_282 k297-0036 65.7 µM -0.00703052113268175 0.499136390622296 no 1674 0.497195250972565 2405 5061378
SGTC_1122 capsaicin 818.572 nM -0.00705722859878398 0.499147522346067 no 1675 0.497184596499455 2429 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2339 9000433 200 µM -0.00752329529917031 0.499341779951676 no 1676 0.496998667729796 2425 2988954
SGTC_426 0988-0037 14.6 µM -0.00870102677223198 0.499832661559957 no 1677 0.496528836336773 2420 5383008
SGTC_3087 9117406 49.47 µM -0.00896053003102251 0.499940823267989 no 1678 0.496425313551799 2450 42546093
SGTC_3109 9122853 49.47 µM -0.00924448549865182 0.499940823267989 no 1679 0.496312036403314 2445 1234709
SGTC_883 0850-0245 24.6 µM -0.0109679012273309 0.499222499073732 no 1680 0.495624528197786 2497 6823229 YPR165W RHO1
SGTC_1935 st074532 41.6 µM -0.0109743992235518 0.499219790695177 no 1681 0.495621936028365 2487 2829742
SGTC_2873 9040596 71.43 µM -0.0113347350973767 0.49906960200141 no 1682 0.495478191756852 2474 6463863
SGTC_259 usnic acid 108.925 µM -0.0113794073003566 0.499050982548988 no 1683 0.495460371275633 2441 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_275 trichlorophene 5.69 µM -0.0114546348944018 0.49901962756076 no 1684 0.495430361763632 2456 62616
SGTC_2852 9023854 51.95 µM -0.0115003018206967 0.499000593511708 no 1685 0.495412144495859 2441 19798528
SGTC_2776 terbinafine 19.92 µM -0.0124667721356902 0.498597767716537 no 1686 0.495026606323088 2417 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1613 st002381 52.1 µM -0.0125971015678625 0.49854344637902 no 1687 0.494974616484899 2435 551167
SGTC_199 4063-0024 41.6 µM -0.014167099815533 0.497889073159265 no 1688 0.494348333948106 2484 306215
SGTC_1107 amlodipine 47 µM -0.0157287007033415 0.497238205579016 no 1689 0.49372541498844 2446 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1705 st027868 56.3335 µM -0.0178676467127796 0.496346715664755 no 1690 0.492872219537658 2485 292948
SGTC_694 1315-0438 43.2 µM -0.0185619168103207 0.496057354989348 no 1691 0.492595291790407 2455 6793154
SGTC_2441 5730946 39.09 µM -0.0186786537857315 0.496008701084166 no 1692 0.492548728548044 2455 1774275
SGTC_2450 5739737 12.93 µM -0.018833782850325 0.495944046127718 no 1693 0.492486851890249 2451 2262825
SGTC_1726 st035556 14.5795 µM -0.0191953325153318 0.49579335925736 no 1694 0.492342640515612 2585 5919439
SGTC_1842 st055362 61.2 µM -0.0196421709019479 0.495607126537816 no 1695 0.492164411399358 2457 676032
SGTC_2176 5809774 33.9695 µM -0.0199242914662115 0.495489545187745 no 1696 0.492051883600984 2450 2870539
SGTC_2148 5546263 113.568 µM -0.0203420279097813 0.49531544298694 no 1697 0.491885264645219 2455 792097
SGTC_660 4031-1742 102 µM -0.0206552727928338 0.495184890863499 no 1698 0.491760324270158 2445 6738706
SGTC_979 1426-2828 121 µM -0.021410232162097 0.494870246054245 no 1699 0.491459205676212 2491 747872
SGTC_1360 1598-0022 39.8 µM -0.0217097128516255 0.494745432204545 no 1700 0.491339757932259 2476 761525
SGTC_851 0394-0702 453 µM -0.0227800564366033 0.494299351962319 no 1701 0.490912858277518 2436 762646
SGTC_1664 st014217 9.02 µM -0.0230112168062034 0.494203013652098 no 1702 0.490820662800807 2451 3982782
SGTC_446 go6976 132 µM -0.0232594634969885 0.494099554829632 no 1703 0.490721653200829 2437 3501 A protein kinase C inhibitor.
SGTC_1129 3453-1384 223 µM -0.0247559870391127 0.493475875156758 no 1704 0.49012479877148 2545 1084452
SGTC_492 tmb-8 126 µM -0.0255131305738926 0.493160339804201 no 1705 0.489822837606786 2445 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2251 lansoprazole 556 µM -0.0256798660721811 0.493090854281704 no 1706 0.489756341553987 2465 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1116 jasmonic acid 1.58368 µM -0.0258212824068859 0.49303192045762 no 1707 0.489699943300698 2453 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_545 4218-0007 221 µM -0.0267086092727115 0.49266213950302 no 1708 0.489346073188227 2480 2840508
SGTC_2489 cantharidin 73.42 µM -0.0267444164193871 0.492647217509972 no 1709 0.489331793304496 2462 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2331 7980721 200 µM -0.027040377344093 0.492523881441785 no 1710 0.489213764665647 2493 2981221
SGTC_2388 9080168 200 µM -0.0303391096752592 0.491149248761481 no 1711 0.487898302953799 2463 15943073
SGTC_1161 k007-0610 110 µM -0.0305947726155528 0.491042714247289 no 1712 0.487796355524205 2467 5843850
SGTC_641 4092-0595 30 µM -0.0312334698746415 0.490776572490201 no 1713 0.487541673914014 2484 786260
SGTC_938 3126-1755 342 µM -0.0326745441431947 0.490176099759604 no 1714 0.486967061939919 2458 1777771
SGTC_868 0527-0199 213 µM -0.0326903327524843 0.490169521018015 no 1715 0.486960766559203 2506 2849450
SGTC_1615 st002656 86.5 µM -0.0336277153511615 0.489778940624371 no 1716 0.486587010554111 2462 1584458
SGTC_1560 lithocholic acid 53.1 µM -0.0336455396253545 0.489771513855256 no 1717 0.486579903719073 2466 9903 A bile acid which acts as a detergent.
SGTC_2100 5377183 190 µM -0.0341433499081776 0.489564094675573 no 1718 0.486381420196684 2509 2844202
SGTC_307 1501-1223 22.3 µM -0.0342942259830135 0.489501230736033 no 1719 0.486321264580571 2487 2830329
SGTC_1354 1498-1681 81 µM -0.0344436368841482 0.48943897753195 no 1720 0.486261693448812 2501 5754243
SGTC_1679 SEC14.276 6.7 µM -0.0350483742318497 0.489187011696644 no 1721 0.486020583743938 2479 1005053 YMR079W SEC14
SGTC_229 benomyl 22.8748 µM -0.0351224626296246 0.489156142813016 no 1722 0.485991044936119 2510 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1773 st048542 73.5835 µM -0.035597050657825 0.4889584075627 no 1723 0.485801830033523 2467 3237138
SGTC_988 1497-1057 103 µM -0.0361109578455326 0.488744293199986 no 1724 0.4855969424652 2455 3533044
SGTC_3279 9140807 49.47 µM -0.036666639729184 0.488512777474141 no 1725 0.485375404193134 2471 45595718
SGTC_1488 4013-0813 75.9 µM -0.0367960783761999 0.488458849541762 no 1726 0.485323800467587 2468 2910057
SGTC_2992 9074591 71.4286 µM -0.0375887675720901 0.48812859663978 no 1727 0.485007781886512 2465 17741321
SGTC_395 anisomycin 6.25 µM -0.0378986280995158 0.487999503680356 no 1728 0.484884253441424 2511 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3042 9091578 49.47 µM -0.039463235268362 0.487347682246587 no 1729 0.484260532337977 2460 25236497
SGTC_1433 4060-0023 7.6 µM -0.0398403094721906 0.487190596654465 no 1730 0.484110219708067 2528 3840627
SGTC_317 4495-0002 170 µM -0.0401429944886041 0.487064502339928 no 1731 0.483989562381999 2511 15991618
SGTC_153 4077-0274 519.67 µM -0.040777850185877 0.48680003461388 no 1732 0.483736498829756 2486 3121976
SGTC_669 0108-0021 26.2 µM -0.041306471785573 0.486579826235458 no 1733 0.483525786868338 2467 17201
SGTC_2253 7938677 135.83 µM -0.0416343173539448 0.48644325736175 no 1734 0.483395107829074 2526 2301972
SGTC_294 k038-0071 157 µM -0.0423605063948571 0.486140758363938 no 1735 0.483105655701349 2517 24152826
SGTC_2346 9031566 143.75 µM -0.0427019514081552 0.485998529860533 no 1736 0.482969561995776 2533 4771086
SGTC_1965 Pectolinarigenin 58.4 µM -0.0441653070537837 0.485388991250976 no 1737 0.482386318008102 2487 5320438 An anti-inflammatory.
SGTC_774 k060-0086 136 µM -0.0445005956408846 0.485249336628405 no 1738 0.482252688598069 2484 5911235
SGTC_2729 fluphenazine 10.66 µM -0.0445421409622593 0.485232032269483 no 1739 0.482236130830963 2491 3372 An atypical antipsychotic.
SGTC_1165 k072-0275 30.3 µM -0.0449912490664263 0.485044972607012 no 1740 0.482057142062976 2488 6153523 YGL055W OLE1
SGTC_520 3584-0023 682 µM -0.0455521918914641 0.484811336882151 no 1741 0.48183358746431 2559 1340790
SGTC_513 4245-1575 41.7 µM -0.0460746162097406 0.484593749011763 no 1742 0.481625388923118 2587 719745
SGTC_2292 7671323 168.05 µM -0.0461113561180549 0.484578447142524 no 1743 0.481610747382019 2541 937504
SGTC_3250 9135583 49.47 µM -0.0469307509896967 0.48423718186965 no 1744 0.481284209671583 2584 7699353
SGTC_1492 4158-0558 28.5 µM -0.0482131555080977 0.483703103520443 no 1745 0.480773182900849 2566 3967268
SGTC_1408 3909-7976 48.8 µM -0.0489745317693674 0.483386029687349 no 1746 0.480469796140727 2516 24152374
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.0490905469727026 0.483337716273151 no 1747 0.480423568374552 2481 4000243
SGTC_1232 0279-0259 161 µM -0.0494308028738133 0.483196021393426 no 1748 0.480287990507511 2505 1560000
SGTC_1569 carminic acid 40.6 µM -0.0507036961142837 0.482665961515158 no 1749 0.479780815683219 2505 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_404 fumagillin 50 µM -0.0516875023475609 0.482256304570724 no 1750 0.479388847805381 2514 12015870 A methionine aminopeptidase binder.
SGTC_1442 4112-3290 3 µM -0.0523965531894456 0.481961067370666 no 1751 0.479106360251424 2486 704353
SGTC_1199 1638-0010 4.46 µM -0.0526466621487136 0.481856928433242 no 1752 0.479006718739461 2495 3111136
SGTC_2496 diffractaic acid 79.83 µM -0.0530876844859644 0.481673301096318 no 1753 0.47883102198636 2496 94870 An apoptosis inducer which activates caspases.
SGTC_2791 5663188 71.43 µM -0.0534433263138952 0.481525226252662 no 1754 0.47868934255533 2548 54690634
SGTC_867 0518-0118 155 µM -0.0536293465710367 0.481447775970587 no 1755 0.478615237483712 2514 6848158
SGTC_572 0960-0087 17.7 µM -0.054787173137523 0.480965726081117 no 1756 0.478154009703862 2492 6796365
SGTC_1520 flindersine 88 µM -0.0561632658297243 0.480392839455146 no 1757 0.477605872286079 2683 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3350 9150499 3.57 µM -0.0574726042468712 0.479847781145404 no 1758 0.477084364335318 2518 4910996 YPR165W RHO1
SGTC_383 2324-0395 7.37 µM -0.0585124858828369 0.479414920523097 no 1759 0.476670208619473 2584 3146421
SGTC_1614 st002383 48.6 µM -0.0587025339881076 0.479335813800288 no 1760 0.476594520495077 2505 1947235
SGTC_1089 terbinafine 2.25 µM -0.0593414695927133 0.479069865534003 no 1761 0.47634006566748 2541 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_548 1436-0017 110 µM -0.0602280937124392 0.478700835749788 no 1762 0.475986985388323 2510 9677137
SGTC_937 3122-0005 46.7 µM -0.0609191576675124 0.478413214463112 no 1763 0.475711796084395 2499 759535
SGTC_1940 st075990 51.1 µM -0.0612320597928812 0.478282988074854 no 1764 0.475587198802573 2736 1084979
SGTC_1807 st050092 58.9 µM -0.0615321507681192 0.478158095722936 no 1765 0.475467705149081 2523 5008496
SGTC_2582 agaric acid 100 µM -0.0619437757103724 0.47798678847383 no 1766 0.475303803217284 2504 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2978 9011784 42.97 µM -0.0623410703126734 0.477821448984298 no 1767 0.475145611342019 2662 2994934
SGTC_2558 carylophyllene oxide 100 µM -0.0625635096490387 0.47772887952934 no 1768 0.475057043774159 2495 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_230 MPP+ 141.667 µM -0.0630897789159514 0.47750987423217 no 1769 0.474847506664576 2548 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0634848669859759 0.477345464036522 no 1770 0.474690204665317 2535 115019
SGTC_1240 0356-0016 42.1 µM -0.0658250694666682 0.476371702563764 no 1771 0.4737585484845 2580 4305613
SGTC_1796 st049173 110.4 µM -0.0665246963627392 0.47608061398001 no 1772 0.473480048201296 2510 94134
SGTC_943 3253-1379 105 µM -0.066604879584352 0.476047253552909 no 1773 0.473448130513989 2583 668464
SGTC_649 1123-0311 367 µM -0.0682615051064309 0.475358048329108 no 1774 0.472788733547908 2568 693629 YIL048W NEO1
SGTC_3247 9135149 49.47 µM -0.0685437194146535 0.475240646121108 no 1775 0.472676409413885 2516 8934436 YOR116C RPO31
SGTC_1078 idebenone 36.1 µM -0.0687588143066276 0.47515116728443 no 1776 0.472590800941438 2589 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_945 3381-0768 11.3 µM -0.0690717356981229 0.475020995153394 no 1777 0.472466259463221 2536 1126236 YIL048W NEO1
SGTC_366 0181-0206 4.31 µM -0.0705770193856105 0.474394849887085 no 1778 0.471867200333631 2552 274874
SGTC_2427 5545055 42.75 µM -0.0710706192577757 0.474189543330661 no 1779 0.471670775729516 2546 5372858
SGTC_2926 9010726 65.15 µM -0.071292138621532 0.474097407408448 no 1780 0.471582625890985 2602 2994293
SGTC_888 0916-0002 6.97 µM -0.0720515872264196 0.473781542646264 no 1781 0.471280426913882 2708 2802138 YIL048W NEO1
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0723321351813678 0.473664863183877 no 1782 0.471168795744794 2528 15053
SGTC_2281 7943571 200 µM -0.0731869687250961 0.473309353201161 no 1783 0.470828668014433 2566 1244024
SGTC_2096 5468907 200 µM -0.0736893226105234 0.473100443103157 no 1784 0.470628797506184 2607 759785
SGTC_635 k038-0028 24.7 µM -0.0738983222791792 0.473013530173109 no 1785 0.470545645413953 2565 4035102
SGTC_1084 voriconazole 435 nM -0.0740360316779995 0.47295626414618 no 1786 0.470490857394137 2549 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2210 7115885 190.385 µM -0.0741107756126361 0.472925182346432 no 1787 0.47046112057145 2543 2927039
SGTC_2130 NSC 7 2.4545 µM -0.0746885889913382 0.472684907828621 no 1788 0.470231243489694 2573 21448
SGTC_2132 5317594 122.667 µM -0.0747333508259914 0.472666294744179 no 1789 0.470213435869375 2548 794577
SGTC_822 1487-0950 154 µM -0.0755552518704495 0.472324538493757 no 1790 0.469886469241673 2541 1958375
SGTC_365 0121-0052 13.6 µM -0.0758459095558042 0.472203684427495 no 1791 0.469770845373143 2593 3101739
SGTC_1651 st011928 86.1 µM -0.0766273459807841 0.47187877964381 no 1792 0.469460001979992 2627 720198
SGTC_2945 9067681 61.76 µM -0.076854230055387 0.471784449526731 no 1793 0.469369754462226 2523 16456930
SGTC_1691 st019933 84.6 µM -0.0773286321780193 0.471587215560402 no 1794 0.469181056956305 2532 6176082
SGTC_1023 4482-3888 16 µM -0.077516053346921 0.471509296619762 no 1795 0.469106510486982 2538 3303168
SGTC_501 nsc-95397 161 µM -0.0776895679483343 0.471437160202012 no 1796 0.469037496297971 2675 262093
SGTC_164 4100-3994 89.624 µM -0.0809929423706098 0.470064007093255 no 1797 0.467723782619226 2539 4615967
SGTC_841 0251-0215 91.2 µM -0.0811991110312337 0.469978318134084 no 1798 0.467641803238838 2614 3888614
SGTC_382 3229-0966 23.2 µM -0.0819450045212125 0.469668317398212 no 1799 0.467345223161104 2625 5722370
SGTC_1317 1273-0028 910 nM -0.08210342957993 0.469602476732533 no 1800 0.467282232961937 2571 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1969 st069479 40.1 µM -0.084558500039478 0.468582269020884 no 1801 0.466306196511189 2622 3895485
SGTC_1871 st057448 67.3 µM -0.0851612610701246 0.468331822175596 no 1802 0.466066593922707 2643 691747
SGTC_1298 1079-1278 263 µM -0.0852736687822116 0.468285118222464 no 1803 0.466021912268092 2580 2840950
SGTC_2393 9031399 185.94 µM -0.086898048207733 0.467610258592505 no 1804 0.465376275478797 2633 1526623 YDL150W RPC53
SGTC_1005 4092-0690 4.4 µM -0.0878856390446936 0.467200002547602 no 1805 0.464983785408365 2605 1529343
SGTC_2620 irigenin 100 µM -0.0887217842616972 0.466852685890059 no 1806 0.464651509734381 2631 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1250 0485-0349 40.2 µM -0.0887951440470523 0.466822215020663 no 1807 0.464622358468564 2595 6842794 YDL195W SEC31
SGTC_2623 humulene 100 µM -0.0889553276579861 0.466755681506865 no 1808 0.464558706338635 2610 6187145 An anti-inflammatory.
SGTC_3330 9141424 71.43 µM -0.089591280405686 0.466491542749555 no 1809 0.464306006884773 2655 27261020
SGTC_818 4072-2707 53.5 µM -0.0906127274964525 0.466067322409345 no 1810 0.463900159229687 2575 882871
SGTC_553 k007-0256 45.7 µM -0.0906396003230549 0.466056162291242 no 1811 0.463889482457816 2614 6287000
SGTC_3145 9085516 49.47 µM -0.0912104101234538 0.465819114842735 no 1812 0.463662701676435 2642 25236195
SGTC_1530 rhein 70.4 µM -0.0918975336439089 0.465533780408338 no 1813 0.463389725519171 2553 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_670 4204-0025 119 µM -0.0920630693196657 0.46546504282186 no 1814 0.463323965107377 2673 719039
SGTC_2525 harmine 47.85 µM -0.0930225992225011 0.465066624783215 no 1815 0.462942803740468 2648 5280953 A monoamine oxidase inhibitor
SGTC_1454 4239-0054 42.6 µM -0.0930386444373458 0.465059962751691 no 1816 0.462936430265873 2741 1340767
SGTC_397 arbidol 50 µM -0.0932250000183425 0.464982587955014 no 1817 0.462862406864967 2717 131410 A RNA synthesis inhibitor.
SGTC_2583 asiatic acid 100 µM -0.0933819381632356 0.464917428298289 no 1818 0.462800069535 2666 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_59 0330-0160 1.33 µM -0.093472608368771 0.464879783070602 no 1819 0.4627640548797 2588 4293482
SGTC_1826 st055655 41.6 µM -0.0934901077017484 0.464872517584766 no 1820 0.462757104092987 2611 676168
SGTC_1055 3448-0672 86 µM -0.093603370985134 0.464825492488187 no 1821 0.462712115857584 2689 748378
SGTC_3019 9081971 49.47 µM -0.094330842491211 0.464523469738898 no 1822 0.46242317518908 2643 16451803
SGTC_3210 9128157 49.47 µM -0.094729652909875 0.46435790515518 no 1823 0.462264782133221 2721 17590849
SGTC_1735 st034310 56.75 µM -0.0949550738300157 0.464264325270973 no 1824 0.462175255752505 2798 871153
SGTC_1784 st039334 36.3 µM -0.0951862519304718 0.464168357438816 no 1825 0.462083444886176 2797 3496984
SGTC_481 bay k-8644 50 µM -0.0952254058429212 0.464152103873261 no 1826 0.462067895366579 2571 2303 A calcium channel antagonist.
SGTC_1429 4049-0205 9.46 µM -0.0962754189085919 0.463716245027263 no 1827 0.461650916626651 2560 22774478
SGTC_2898 9056270 58.44 µM -0.0964559216085304 0.463641322999496 no 1828 0.461579240048476 2564 19154699
SGTC_1347 1493-0251 600 nM -0.0974745667773852 0.463218533840442 no 1829 0.46117476540348 2651 3986378
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0975269800103296 0.463196780822986 no 1830 0.461153954701705 2821 6710655
SGTC_1730 st033808 45.1 µM -0.0976206758645435 0.463157894590176 no 1831 0.461116752978481 2590 1045166
SGTC_585 0kpi-0023 191 µM -0.0977026145733027 0.46312388816911 no 1832 0.461084219681685 2631 64601
SGTC_115 0527-0192 112.043 µM -0.098167410707945 0.462930992346926 no 1833 0.460899679963716 2641 4233931
SGTC_2934 9036370 36.88 µM -0.0985811803604534 0.462759280442484 no 1834 0.460735406560459 2664 6462800
SGTC_2466 5983409 37.09 µM -0.100513325111135 0.461957544423984 no 1835 0.459968402251184 2634 2879657
SGTC_2515 chrysin 20.77 µM -0.101431881602096 0.46157644695147 no 1836 0.459603814558888 2693 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2049 5262831 67.185 µM -0.10297199308894 0.460937553508365 no 1837 0.458992599523191 2614 763417
SGTC_83 0170-0301 39.027 µM -0.103139006501524 0.460868276388631 no 1838 0.458926323686827 2578 3089716
SGTC_1758 st042942 75.2445 µM -0.103466590795435 0.460732397960577 no 1839 0.458796331917418 2570 669317
SGTC_607 4491-0986 66.8 µM -0.104534197239004 0.460289598236265 no 1840 0.458372715727883 2654 698981 YDR232W HEM1
SGTC_985 1493-0307 8.71 µM -0.106651875435942 0.459411417701129 no 1841 0.457532581297886 2626 3278274
SGTC_2488 5268135 45.7 µM -0.106962187506741 0.459282750836691 no 1842 0.457409488803093 2697 1270356 YLR208W SEC13
SGTC_1036 k216-0215 33.5 µM -0.108033086345684 0.458838749400025 no 1843 0.456984723342227 2588 622330
SGTC_2605 digitonin 300 nM -0.108211033186435 0.458764976473291 no 1844 0.456914146566561 2593 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2347 9049783 174.81 µM -0.109296108164424 0.458315158587852 no 1845 0.456483816669729 2690 6467988 YPL169C MEX67
SGTC_292 k038-0015 474 µM -0.109736327060388 0.458132681010959 no 1846 0.456309244776585 2709 46368540
SGTC_1817 st052116 64.4 µM -0.110673841437922 0.457744096178421 no 1847 0.455937495014972 2701 4361398
SGTC_620 0109-0052 432 µM -0.110804584849189 0.457689908309708 no 1848 0.455885654779762 2624 493037
SGTC_1841 st054148 70 µM -0.111698477972636 0.457319446799637 no 1849 0.455531243090439 2662 675442
SGTC_1121 fusaric acid 630.51 nM -0.111922885269734 0.457226450142974 no 1850 0.455442275394057 2640 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1376 2910-0861 41.3 µM -0.112625031187317 0.456935488915818 no 1851 0.455163919645162 2610 1112859
SGTC_1875 nocodazole 6 µM -0.11307001438654 0.456751104914981 no 1852 0.45498752377988 2589 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3069 9117009 49.47 µM -0.1138238784723 0.456438753770382 no 1853 0.4546887046622 2612 41904981
SGTC_1908 st060353 56.5 µM -0.115550291730316 0.455723544630658 no 1854 0.454004480179717 2714 4227716
SGTC_2903 5923464 63.88 µM -0.115770066893383 0.455632507611084 no 1855 0.453917387062076 2614 2876576
SGTC_387 norethindrone acetate 66.7 µM -0.117069543311011 0.455094275899169 no 1856 0.453402472329815 2670 541197
SGTC_320 4092-0846 5.34 µM -0.117453659926564 0.45493519391103 no 1857 0.45325028190799 2705 1359356
SGTC_1995 st072814 61.1 µM -0.118336314664711 0.454569669664782 no 1858 0.452900592297138 2625 5769371
SGTC_505 gw-5074 63.9 µM -0.118573860224509 0.454471304051525 no 1859 0.452806487869645 2731 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3264 9137442 49.47 µM -0.118686442392373 0.454424685699983 no 1860 0.452761889011975 2767 17015726
SGTC_2970 9090938 41.86 µM -0.118697353038827 0.454420167821121 no 1861 0.452757566846107 2661 17217104
SGTC_2951 9072950 58.06 µM -0.119015968261388 0.454288238279935 no 1862 0.452631352428763 2605 16488155
SGTC_1065 prochlorperazine maleate 2.48 µM -0.119438140131147 0.454113436634097 no 1863 0.45246412304596 2619 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3245 9134821 49.47 µM -0.119621409738387 0.45403755601733 no 1864 0.452391529493113 2612 17014901
SGTC_773 4358-1457 44.6 µM -0.119823309022367 0.453953963945092 no 1865 0.45231155852083 2602 1186886
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.120268215950273 0.453769766969855 no 1866 0.452135340659917 2677 4213774
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.120437946436587 0.453699499065825 no 1867 0.452068116625545 2615 803109
SGTC_1341 1486-1360 280 µM -0.120480488918967 0.453681886834867 no 1868 0.452051267320417 2600 3976547
SGTC_1206 3978-0017 132 µM -0.121797048221381 0.453136887522379 no 1869 0.451529875862475 2904 3873677
SGTC_2520 obtusaquinone 4.71 µM -0.122151838394593 0.452990034600088 no 1870 0.451389384061281 2745 5967872
SGTC_145 3737-0113 38.366 µM -0.123657770499468 0.452366778733747 no 1871 0.450793124604498 2732 6849351
SGTC_619 1652-1634 108 µM -0.124828688994668 0.451882255021376 no 1872 0.450329587247711 2685 5400454
SGTC_486 niguldipine 82 µM -0.125618778970509 0.451555357829375 no 1873 0.450016848621435 2604 1236 A calcium channel blocker.
SGTC_2528 xanthyletin 44.79 µM -0.125962663596288 0.451413086915642 no 1874 0.449880739623506 2659 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3149 9097855 49.47 µM -0.126564228684658 0.451164224233284 no 1875 0.44964265528778 2743 25236625 YMR079W SEC14
SGTC_414 piperonyl butoxide 100 µM -0.129304339678817 0.450030906434843 no 1876 0.44855841884819 2638 5794 A potent inhibitor of cytochrome P450.
SGTC_1857 st056007 79.3 µM -0.129682564119738 0.449874503506893 no 1877 0.448408788940637 2712 619834
SGTC_2414 st077232 92.9 µM -0.131546439551871 0.449103870101793 no 1878 0.447671526136314 2613 729801
SGTC_3039 9090270 49.47 µM -0.131864726297722 0.448972291146248 no 1879 0.447545644637936 2665 17173750
SGTC_189 3970-0742 2.116 µM -0.131931011094838 0.448944889880198 no 1880 0.447519429854388 2654 2891807
SGTC_2879 9041815 71.43 µM -0.132579901619649 0.448676659925271 no 1881 0.447262814133538 2640 4942971
SGTC_1860 st056228 74.6 µM -0.132997735887808 0.448503953419125 no 1882 0.447097585546572 2758 688679
SGTC_1698 5-fluorocytosine 1.055 µM -0.133656897859424 0.448231517014997 no 1883 0.446836944893488 2660 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1176 0848-0131 83.3 µM -0.133697900629322 0.448214571079276 no 1884 0.446820732657483 2737 6769040
SGTC_1970 st070122 35.8 µM -0.13453941872392 0.44786680301422 no 1885 0.44648802139089 2784 102928
SGTC_876 0720-0963 56.8 µM -0.135294095387471 0.447554957347132 no 1886 0.446189676677252 2839 765861
SGTC_2043 5101342 149 µM -0.136223500551329 0.447170955353254 no 1887 0.445822298791925 2675 678451
SGTC_1416 3966-0321 25.3 µM -0.136414373410962 0.44709209860066 no 1888 0.445746855777983 2698 582530 YLR208W SEC13
SGTC_1370 2001-0092 44.6 µM -0.137555583282692 0.446620665653097 no 1889 0.445295830565698 2750 790957
SGTC_1138 3761-0006 1.03 µM -0.138421141318429 0.44626315453833 no 1890 0.444953794745481 2636 12061087
SGTC_1797 st048695 56.8 µM -0.139160262414139 0.445957901649222 no 1891 0.444661754451211 2757 592262 YIL048W NEO1
SGTC_2913 7966556 36.57 µM -0.139542331345341 0.445800121857966 no 1892 0.444510803778998 2655 2976516
SGTC_2304 7443016 91.4 µM -0.139694647983655 0.445737223329151 no 1893 0.4444506276163 2620 939854
SGTC_697 0508-1955 564 µM -0.14053822291685 0.445388897301607 no 1894 0.444117377314708 2700 6243113
SGTC_208 k072-0098 12.366 µM -0.141890737396329 0.444830509811702 no 1895 0.443583155389038 2665 5948901
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.143011966731148 0.444367691648796 no 1896 0.443140365128977 2757 551469
SGTC_41 0478-0632 82.643 µM -0.143159336419689 0.444306866393578 no 1897 0.443082171898576 2655 3750424
SGTC_2752 diclazuril 33.15 µM -0.143428207723165 0.444195896033092 no 1898 0.442976003367147 2767 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1052 3253-3998 198 µM -0.14407746101556 0.4439279499298 no 1899 0.442719651256282 2642 5450317
SGTC_1224 0823-0416 294 µM -0.144166098794232 0.443891371203899 no 1900 0.44268465524522 2773 3598164
SGTC_807 1315-0151 48 µM -0.144921648685107 0.443579592973397 no 1901 0.44238636684806 2693 4011080
SGTC_1283 0922-0125 16.4 µM -0.144995490341274 0.443549124028626 no 1902 0.442357216175288 2768 3360884
SGTC_3233 9132340 49.47 µM -0.146013664707694 0.443129033501183 no 1903 0.441955300582156 2676 17682950
SGTC_3256 9138902 49.47 µM -0.146410831586294 0.442965182955282 no 1904 0.441798538541479 2632 17228773
SGTC_1837 st055472 66.5 µM -0.146767970493702 0.442817854210877 no 1905 0.441657583351566 2824 676091
SGTC_684 1140-0066 328 µM -0.14738500444658 0.442563330892533 no 1906 0.441414070491131 2729 6813534
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.148694393064639 0.442023293502388 no 1907 0.440897392869487 2753 688662
SGTC_1077 5-fluorocytosine 377 nM -0.148955377618107 0.441915667243825 no 1908 0.44079442178 2749 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_315 k915-0449 187 µM -0.149400445807838 0.44173213744899 no 1909 0.440618829987593 2700 20970215 YNL149C PGA2
SGTC_406 estrone 100 µM -0.149524576691978 0.441680952655105 no 1910 0.440569858978531 2809 5870 A steroid.
SGTC_440 fluspirilene 35.1 µM -0.149747285433039 0.441589122181068 no 1911 0.440482000191502 2928 3396 An atypical antipsychotic.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.151714217262963 0.44077822539952 no 1912 0.439706171614024 2698 6708514
SGTC_2584 androsterone 48.74 µM -0.152066635742849 0.440632961788457 no 1913 0.439567189472911 2731 2754130 A steroid.
SGTC_453 enantio-paf c16 10 µM -0.152940878957825 0.440272641417778 no 1914 0.439222449182326 2743 13871343 A lipid and platelet activating factor
SGTC_76 0433-0009 400.328 µM -0.15354385089362 0.44002415462392 no 1915 0.43898470612594 2828 2841569
SGTC_43 0570-0105 72.5 µM -0.153743627988297 0.439941831005953 no 1916 0.438905941775869 2685 1114046 YDL195W SEC31
SGTC_1827 berberine 7.24 µM -0.153817601811933 0.439911348726469 no 1917 0.438876777383557 2681 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.154162085263854 0.439769402655773 no 1918 0.438740968167161 2839 688751
SGTC_2025 5147754 141 µM -0.154253073926293 0.439731911629631 no 1919 0.438705097984356 2765 315777 YLR208W SEC13
SGTC_534 k292-0788 63.4 µM -0.154259896809845 0.439729100346147 no 1920 0.438702408240077 2660 4146317
SGTC_1570 verbenone 133 µM -0.154430668489779 0.439658737010386 no 1921 0.438635086871958 2809 29025 A natural terpanoid with antifungal properties.
SGTC_814 3342-0569 96 µM -0.154626338185618 0.439578117247593 no 1922 0.438557952426176 2678 4346283
SGTC_1464 k208-0027 110 µM -0.154816351812556 0.439499830294519 no 1923 0.438483049878198 2848 X1464
SGTC_129 0088-0017 176.636 µM -0.157749301837103 0.438291736169532 no 1924 0.437327174792598 2713 182446
SGTC_2915 7971052 15.16 µM -0.159482127487225 0.437578247587795 no 1925 0.436644519148377 2670 5741558
SGTC_1746 st038117 42 µM -0.159899373364912 0.437406477396525 no 1926 0.43648017107545 2797 2898218
SGTC_280 3448-3607 3.04 µM -0.160589963304186 0.437122203900277 no 1927 0.436208180208777 2720 626179
SGTC_2156 5649887 115 µM -0.160660996723048 0.437092965639752 no 1928 0.436180205197741 2801 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2013 4024628 200 µM -0.160768310507222 0.437048794570149 no 1929 0.436137942536991 2836 5230760
SGTC_1794 st048918 76.9 µM -0.161227443433891 0.436859821261552 no 1930 0.435957133565327 2651 672303
SGTC_106 0092-0003 11.579 µM -0.162398591507956 0.436377856860895 no 1931 0.435495989965258 2798 1072148
SGTC_2814 7977482 42.97 µM -0.163622314655675 0.435874357063782 no 1932 0.435014238449747 2840 6456762
SGTC_1756 st041558 35.5 µM -0.166013231325907 0.434890917113069 no 1933 0.434073268785434 2834 3955792
SGTC_301 4119-0100 24.5 µM -0.166629289714863 0.434637582887952 no 1934 0.433830873012204 2706 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2828 7998861 71.43 µM -0.167540723372015 0.434262834318357 no 1935 0.433472303857833 2760 2988188
SGTC_2211 7117706 200 µM -0.167642806927752 0.434220864922911 no 1936 0.433432146341935 2752 822771
SGTC_1748 st037455 53.6035 µM -0.169018385149392 0.433655398866285 no 1937 0.432891090094978 2874 580690
SGTC_1816 st051957 91.6 µM -0.169335397534557 0.433525102152295 no 1938 0.432766417395952 2727 674121
SGTC_1744 st037937 38.9 µM -0.169482279135748 0.433464734120097 no 1939 0.43270865496292 2863 1016152
SGTC_2973 9094665 17.96 µM -0.169731478992249 0.433362317049595 no 1940 0.432610658299765 2944 25237061 YIL048W NEO1
SGTC_124 0136-0217 7.121 µM -0.170238865119628 0.433153803477068 no 1941 0.432411143925895 2765 3976905
SGTC_1358 1509-0022 2.48 µM -0.17043511019994 0.433073160293972 no 1942 0.432333981053917 2748 3258434
SGTC_2415 st077333 57.7 µM -0.17151994854291 0.432627416985532 no 1943 0.431907473096757 2880 2766255
SGTC_347 4534-1311 26.2 µM -0.171693449523858 0.432556136050557 no 1944 0.431839267932158 2684 2862016
SGTC_2126 5251174 33.877 µM -0.171999007133712 0.432430606466379 no 1945 0.431719154779611 2820 790722
SGTC_650 1328-0195 38 µM -0.172635107254384 0.432169304858858 no 1946 0.431469127297634 2704 2780821
SGTC_2861 9024595 19.48 µM -0.172883469170072 0.432067289080276 no 1947 0.431371512841528 2770 16482810
SGTC_2857 9024691 58.44 µM -0.172981227908132 0.432027135479039 no 1948 0.43133309156991 2822 16478292
SGTC_800 3448-7362 155 µM -0.174194848555387 0.431528709330681 no 1949 0.430856166951897 2780 15991913
SGTC_3150 9097574 49.47 µM -0.174422064467348 0.431435405315485 no 1950 0.430766887579845 2809 17217476
SGTC_1 0258-0098 57.368 µM -0.176610409768647 0.430536979097306 no 1951 0.429907208406238 2778 6790032 YDR047W HEM12
SGTC_953 1188-0045 9.7 µM -0.17670540517485 0.430497986794168 no 1952 0.429869897488186 2831 6144426
SGTC_3121 9125696 49.47 µM -0.177929865655001 0.429995449238634 no 1953 0.429389027837939 2671 1235365
SGTC_1972 st070201 17.4 µM -0.181095358243189 0.428696809425906 no 1954 0.428146363973209 2835 2829099
SGTC_2990 9074105 71.4286 µM -0.182743236889282 0.428021073537177 no 1955 0.427499744414966 2731 6502001
SGTC_2956 9076196 2.52 µM -0.18292524381504 0.427946451934847 no 1956 0.427428337691885 2827 16423868
SGTC_2196 6573537 42.6665 µM -0.183140750315196 0.427858099066897 no 1957 0.427343791164891 2824 2903087
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.18385036555413 0.427567198202185 no 1958 0.427065421755384 2707 2333 A French combination drug.
SGTC_3096 9117468 49.47 µM -0.183938619252089 0.427531022082472 no 1959 0.42703080393905 2858 41316311
SGTC_2649 anisomycin 9.56 µM -0.184473632617464 0.427311727526102 no 1960 0.426820955146592 2775 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2681 menadione 3.18 µM -0.184566536893789 0.427273649638703 no 1961 0.426784517324201 2795 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2398 5228213 48.84 µM -0.185700193412491 0.426809062141474 no 1962 0.426339938319073 2869 80771 YMR134W ERG29
SGTC_516 3992-2719 87.3 µM -0.186261025469282 0.426579263209509 no 1963 0.426120034875471 2688 5350887 YDR037W KRS1
SGTC_3053 9095903 49.47 µM -0.186337513229709 0.426547924552333 no 1964 0.42609004564025 2742 17174018
SGTC_840 0245-0196 390 µM -0.186799856320307 0.426358502665534 no 1965 0.42590877978685 2865 3827528
SGTC_473 2-arachidonoylglycerol 10 µM -0.186903660541204 0.426315976427079 no 1966 0.42586808453961 2708 5282280 An endocannabinoid.
SGTC_3089 9117425 49.47 µM -0.187326469112784 0.42614277018726 no 1967 0.425702335478754 2811 9401657
SGTC_1787 fluconazole 80 µM -0.188070426620199 0.425838037835548 no 1968 0.42541072177024 2773 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2104 5389443 200 µM -0.188214951598839 0.425778844106707 no 1969 0.42535407613224 2907 2244536
SGTC_272 doxorubicin 8.13 µM -0.189270396199706 0.425346611826463 no 1970 0.424940448180156 2715 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1694 st024011 44.9 µM -0.189602639479399 0.425210568018774 no 1971 0.424810259363052 2759 2787533
SGTC_1157 4092-0394 27.6 µM -0.190680150054771 0.424769420623986 no 1972 0.424388095651097 2927 3659885
SGTC_1325 1431-0015 227 µM -0.192637704891824 0.423968212617961 no 1973 0.423621356861628 2743 1103340
SGTC_1765 st044815 90.4 µM -0.192877214491769 0.42387020519127 no 1974 0.423527565079211 2831 645695
SGTC_2099 5377090 177.372 µM -0.193373096633967 0.423667304988161 no 1975 0.423333391775958 2826 2243829
SGTC_913 3487-1245 167 µM -0.193510199972437 0.423611209954361 no 1976 0.423279709302615 2716 4016153
SGTC_161 4065-0411 162.148 µM -0.193962928230447 0.423425989821642 no 1977 0.423102454793571 2875 1906281 YLR208W SEC13
SGTC_2658 polymyxin b sulfate 77.05 µM -0.196190605629962 0.42251484991559 no 1978 0.422230490398092 2775 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1974 st069448 26.9 µM -0.19629337147777 0.422472827731242 no 1979 0.422190274632993 2889 6323587 YNR016C ACC1
SGTC_2847 9005661 71.43 µM -0.196313009979239 0.422464797413503 no 1980 0.422182589512964 2746 2991449
SGTC_664 1222-0054 14.9 µM -0.196577433451133 0.422356675984519 no 1981 0.422079115760656 2776 6813991
SGTC_1514 1189-1591 158 µM -0.196798503304029 0.422266286122385 no 1982 0.421992611201945 2960 767698 YMR146C TIF34
SGTC_2355 9061122 103.12 µM -0.19706142279881 0.42215879033204 no 1983 0.421889735792329 2888 5302957
SGTC_403 arphamenine a 50 µM -0.198059848125337 0.421750632635661 no 1984 0.421499119515491 2753 5487158 An arginine aminopeptidase inhibitor.
SGTC_1448 4255-0083 152 µM -0.198089812321175 0.421738384526548 no 1985 0.421487397744931 2915 5399660
SGTC_1333 1482-0047 286 µM -0.198733277363121 0.421475381237978 no 1986 0.421235695812319 2836 3811116
SGTC_466 geldanamycin 89.2 µM -0.200151317512404 0.420895909893586 no 1987 0.420681119848788 2820 5288382 HSP90 inhibitor.
SGTC_763 3453-1109 128 µM -0.20110228171507 0.420507401491178 no 1988 0.420309298945962 2867 1560353
SGTC_2607 solasodine 47.35 µM -0.202603317539718 0.419894323661851 no 1989 0.419722548380225 2798 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1943 st076331 65.2 µM -0.203716128013347 0.419439936602753 no 1990 0.419287669074984 2850 24208415
SGTC_3172 9105863 49.47 µM -0.207131178137813 0.418046163259923 no 1991 0.417953706712067 2813 2348785
SGTC_2317 5986382 200 µM -0.207622849257618 0.417845583415475 no 1992 0.417761730996703 2832 877883
SGTC_2586 curcumin 80 µM -0.207872161142015 0.417743883470049 no 1993 0.417664393273711 2905 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2465 5809242 33.21 µM -0.209952188801736 0.416895608266523 no 1994 0.416852494542996 2760 2731748
SGTC_2163 5671233 125 µM -0.211836107376878 0.416127643773025 no 1995 0.416117449052076 2944 701023
SGTC_1803 st050068 52.4 µM -0.212418396083191 0.415890343017099 no 1996 0.415890317618712 2781 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_257 daunorubicin 18.5 µM -0.212517313544589 0.415850034120084 no 1997 0.415851736000501 2892 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2233 sulbentine 40.3845 µM -0.217574313369623 0.41379049377292 no 1998 0.413880399997362 2808 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3275 9138069 49.47 µM -0.218496083603869 0.41341534239479 no 1999 0.413521304720639 2867 17617007
SGTC_3338 9144300 39.5675 µM -0.218748774621863 0.413312513435066 no 2000 0.413422876156232 2856 4901274
SGTC_2708 st078559 56 µM -0.218820445676954 0.413283349016562 no 2001 0.413394959735143 2836 17250902
SGTC_1548 st061468 90.8 µM -0.219506755043316 0.413004099946706 no 2002 0.413127659205742 2916 390799
SGTC_3272 9137413 49.47 µM -0.220005331780043 0.412801264083028 no 2003 0.412933501137813 2775 17614870
SGTC_2979 9012552 45.46 µM -0.220086959420385 0.412768057744432 no 2004 0.412901715350574 2886 17100905
SGTC_1899 st063254 59.6 µM -0.220870189796562 0.412449469333067 no 2005 0.41259675465031 2772 3093813
SGTC_2408 sulbentine 18.36 µM -0.221382244396654 0.41224121610824 no 2006 0.412397408190576 2870 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2958 9077254 16.72 µM -0.221411371631978 0.412229370768587 no 2007 0.412386069431633 2989 16457351
SGTC_1624 st003710 6.25 µM -0.221659253773976 0.412128566354575 no 2008 0.412289575905798 2985 24207033
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.222752710319173 0.411683967673007 no 2009 0.411863987468206 2786 688803
SGTC_2805 7950783 58.44 µM -0.223059050034265 0.411559430459138 no 2010 0.411744774372301 2917 1178958 YDL195W SEC31
SGTC_3331 9141060 1.957 µM -0.223315256326046 0.411455280979171 no 2011 0.411645077115828 2799 4906567 YPR165W RHO1
SGTC_1483 3453-0561 55.9 µM -0.223425082748627 0.411410637752991 no 2012 0.411602342233934 2893 4546991
SGTC_3045 9092950 49.47 µM -0.225501362389576 0.41056686948172 no 2013 0.410794632814762 2887 44120432
SGTC_1373 2887-0003 58.5 µM -0.227056286638701 0.409935242786464 no 2014 0.410189987259645 2889 776948
SGTC_2002 4023503 131 µM -0.227056736412778 0.409935060117192 no 2015 0.41018981239197 2862 4736863 YCR052W RSC6
SGTC_2379 9035213 200 µM -0.228944690243659 0.409168467534965 no 2016 0.409455952552643 2949 646551
SGTC_1420 4'-methoxyflavone 42 µM -0.229969981542926 0.408752299320966 no 2017 0.409057547926915 2856 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_539 4859-0462 2.54 µM -0.230025495222956 0.408729769115473 no 2018 0.40903597926413 2992 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_956 1185-0240 191 µM -0.231178150317348 0.408262032745761 no 2019 0.408588201900816 2833 1416193
SGTC_3310 9130229 44.1445 µM -0.231474374887974 0.408141848739666 no 2020 0.408473145391311 2981 7761258
SGTC_2014 4013930 200 µM -0.233554169347481 0.407298280054845 no 2021 0.407665555634224 2839 64556
SGTC_1636 st007707 68.9 µM -0.233580911910555 0.407287436009405 no 2022 0.407655173972152 2988 403051
SGTC_819 1013-0258 27.7 µM -0.233768956441138 0.407211186408448 no 2023 0.407582175517077 2838 5753198
SGTC_1717 st033143 58.0435 µM -0.233807161014864 0.407195695382485 no 2024 0.407567344981381 2983 674616
SGTC_224 benfluorex 43.875 µM -0.234106533223864 0.40707431225615 no 2025 0.407451137037554 2921 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_589 1227-0070 34.1 µM -0.234245692079152 0.40701789209757 no 2026 0.407397122222351 2947 2841384
SGTC_631 k072-0230 41.5 µM -0.234884347652603 0.406758982217656 no 2027 0.407149249257397 2928 5773147
SGTC_1637 st007924 17.4 µM -0.237115289232127 0.40585488280132 no 2028 0.406283675732207 2810 683336
SGTC_1828 st055811 49 µM -0.237565370831765 0.405672545834641 no 2029 0.406109105848432 2972 5877589
SGTC_3101 9120531 49.47 µM -0.238177920103379 0.405424422883188 no 2030 0.405871550801109 3038 24824904
SGTC_576 1073-0113 22.7 µM -0.238591601510052 0.405256876056365 no 2031 0.405711139052017 2874 5439563
SGTC_804 1595-0054 20.9 µM -0.239635655605115 0.404834096633185 no 2032 0.40530636041493 2840 761523 Stimulates phospholipase C.
SGTC_2597 laccaic acid a 100 µM -0.240352051432181 0.404544063417289 no 2033 0.405028673085323 2973 5491415 A textile dye.
SGTC_725 1497-0963 19 µM -0.241667252683043 0.404011740145224 no 2034 0.404519003039128 2962 3549977
SGTC_357 1325-0123 420 µM -0.24222454622137 0.403786231010435 no 2035 0.404303088075041 2965 1098503
SGTC_1657 st012939 43.4 µM -0.243297872765002 0.403351999001418 no 2036 0.403887326090802 2988 24207257
SGTC_671 0560-0003 407 µM -0.243835103589664 0.403134698087925 no 2037 0.403679265990518 2882 3238678
SGTC_2057 5236571 38.335 µM -0.243847143610401 0.403129828442656 no 2038 0.403674603413133 2992 54684039 YBR257W POP4
SGTC_3134 9127454 49.47 µM -0.244094959809082 0.40302960130707 no 2039 0.403578637998301 2879 24262820
SGTC_1131 3454-3128 32.3 µM -0.245219808248925 0.402574746186705 no 2040 0.403143119886097 3001 710982
SGTC_1211 1056-0033 32.3 µM -0.24567735198045 0.402389766853489 no 2041 0.402966002727951 2933 6741922
SGTC_3177 9107506 49.47 µM -0.246030279397762 0.402247097544477 no 2042 0.402829396596584 2959 8897194
SGTC_905 2-aminofluorene 215 µM -0.246169812817488 0.402190695382615 no 2043 0.402775391253364 2837 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2279 7948423 32.93 µM -0.246996904454959 0.401856410470855 no 2044 0.402455309878591 3056 1247112
SGTC_2556 citropten 84.59 µM -0.247524558319415 0.401643186557632 no 2045 0.402251143951721 2848 2775 A potential DNA crosslinker.
SGTC_2491 paeonol 100 µM -0.247921044635074 0.401482986461168 no 2046 0.402097748429989 2808 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1470 k295-0292 231 µM -0.248200403794586 0.401370121474365 no 2047 0.401989676970926 2949 5045612
SGTC_514 4466-0038 2.65 nM -0.250270240091506 0.400534135758919 no 2048 0.401189184620784 2886 5722064
SGTC_48 0382-0018 55 µM -0.250827160625504 0.400309278845512 no 2049 0.400973870779441 3116 762596
SGTC_861 0443-0273 110 µM -0.251455243121139 0.400055729903523 no 2050 0.400731080743533 2946 6149169
SGTC_2523 spermine 47.74 µM -0.252454449792133 0.399652449691449 no 2051 0.400344908907825 2981 1103 A DNA binding polyamine.
SGTC_1540 guanosine 70.6 µM -0.253786998381339 0.399114799154182 no 2052 0.399830059231647 2822 6802 Guanosine is a purine nucleoside
SGTC_82 0054-0107 293.755 µM -0.254768854717048 0.398718766667432 no 2053 0.399450815990188 2928 3104697
SGTC_728 3030-5151 22.5 µM -0.254966248350377 0.398639160372386 no 2054 0.399374583892409 2859 3125388
SGTC_499 genistein 192 µM -0.257214533513956 0.397732754414936 no 2055 0.398506582619692 2909 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1854 st056233 32.9 µM -0.258064660670087 0.397390165451288 no 2056 0.398178502353834 2930 5393174
SGTC_2102 5377816 72.7585 µM -0.258628166248235 0.397163124440935 no 2057 0.397961074464489 3052 1379702
SGTC_400 oxethazaine 37.5 µM -0.259181793635595 0.396940097367059 no 2058 0.397747488918751 2928 4621 A local anesthetic.
SGTC_3224 9130643 49.47 µM -0.260302120135903 0.396488880493891 no 2059 0.397315368664478 3065 17644395
SGTC_1552 6-methylflavone 10.6 µM -0.261029953344972 0.39619581640443 no 2060 0.397034704174985 2888 689013
SGTC_2946 9065502 71.43 µM -0.261588043704668 0.395971139470284 no 2061 0.396819531436027 2888 16489101
SGTC_3133 9127736 49.47 µM -0.261819509355952 0.395877965781608 no 2062 0.39673029865081 2954 27243420
SGTC_1457 k015-0032 57.3 µM -0.261908727656245 0.395842053625808 no 2063 0.396695905369417 2837 4302660
SGTC_1106 tegaserod maleate 11.7 µM -0.262066467868639 0.395778562189309 no 2064 0.396635099144357 2921 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1688 st021091 57.6 µM -0.262228357456112 0.395713403478432 no 2065 0.396572696017946 2991 3656366
SGTC_1440 4100-1550 40 µM -0.263309610516659 0.395278286286692 no 2066 0.396155976431606 2894 742806
SGTC_698 k064-0052 127 µM -0.263610729446425 0.395157133406816 no 2067 0.396039944997867 2851 5088751
SGTC_808 0711-0032 135 µM -0.264041104860929 0.394983992772965 no 2068 0.395874122605991 2939 4252555
SGTC_2173 5763948 167 µM -0.26526533568483 0.394491596480434 no 2069 0.395402533168077 2848 2867177
SGTC_869 0564-0080 44.1 µM -0.265398293710106 0.394438129737258 no 2070 0.395351325235194 2914 6843321
SGTC_1923 st058458 19.1 µM -0.266878761630836 0.393842920046292 no 2071 0.394781254754555 3121 3534982
SGTC_263 alizarin 107.927 µM -0.267601918091095 0.393552271100982 no 2072 0.394502877186719 2900 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1991 st073000 8.92 µM -0.268086683916878 0.393357468617705 no 2073 0.394316297744166 3073 4301969 YIL048W NEO1
SGTC_2983 9022671 12.99 µM -0.268625521533456 0.393140968787506 no 2074 0.394108935297087 3073 6405161
SGTC_537 1334-0398 209 µM -0.269157800215468 0.392927136718218 no 2075 0.393904126410502 3052 5846986
SGTC_2848 9016370 25.97 µM -0.269265547808675 0.392883855257068 no 2076 0.393862671124711 2969 7894410
SGTC_1288 0973-0013 65.5 µM -0.269529642557897 0.392777775829351 no 2077 0.393761067229888 2974 4315430
SGTC_1017 4239-0030 168 µM -0.270326076729514 0.39245791888873 no 2078 0.393454702782912 2885 1149593
SGTC_509 pifithrin 175 µM -0.271467893909591 0.391999478993481 no 2079 0.393015594905183 2960 4817 A p53 inhibitor.
SGTC_896 0964-0007 44.5 µM -0.271679940248417 0.391914358817242 no 2080 0.392934063352158 2955 6756758
SGTC_562 3772-2733 112 µM -0.27273113933051 0.391492460294043 no 2081 0.392529948037018 3002 2876874 YIL048W NEO1
SGTC_73 0327-0325 16.231 µM -0.274998411637738 0.390582926076303 no 2082 0.391658729305495 3019 53298
SGTC_1415 3966-0071 78.1 µM -0.276846939908637 0.389841816893606 no 2083 0.390948818209006 2931 2893185
SGTC_2931 9014674 55.67 µM -0.276891770916797 0.389823848274182 no 2084 0.390931605754979 2900 2996810
SGTC_67 0335-0847 266 µM -0.277099305787503 0.389740669740093 no 2085 0.39085192743104 3234 4552207 YOR254C SEC63
SGTC_293 4049-0273 38.5 µM -0.27782330499328 0.389450535447923 no 2086 0.390574000190702 2943 1380311
SGTC_192 3455-0609 60.9 µM -0.278676247021581 0.389108807868265 no 2087 0.390246646387505 3029 3769639
SGTC_3254 9136651 49.47 µM -0.278877322432491 0.389028260345788 no 2088 0.390169486229658 2926 16454030
SGTC_2834 9001755 58.44 µM -0.279913324674958 0.388613330443178 no 2089 0.389772002047689 2963 2989575
SGTC_1155 4088-0394 48.2 µM -0.28062702304523 0.38832756054797 no 2090 0.389498243587749 2863 2326248
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.280665428922809 0.38831218427434 no 2091 0.389483513520079 2857 5355888
SGTC_967 1306-0166 352 µM -0.281997109166064 0.387779137847853 no 2092 0.388972863470074 3067 4437607
SGTC_1243 0416-0003 5.65 µM -0.282055209253617 0.3877558862872 no 2093 0.388950588597334 2940 2141977
SGTC_254 nsc-64875 3.808 µM -0.282126106750994 0.387727513769168 no 2094 0.388923407846525 3054 56993
SGTC_758 0868-0029 16 µM -0.282162585552469 0.387712915526186 no 2095 0.388909422780314 3015 762687
SGTC_250 brefeldin a 552.239 µM -0.282774685671558 0.387467986370928 no 2096 0.388674780287222 2881 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3162 9099653 49.47 µM -0.28459810677388 0.386738618240403 no 2097 0.387976030936091 3006 25237511
SGTC_1881 5652484 16 µM -0.284758518036841 0.386674472861247 no 2098 0.387914577392171 3059 2255129
SGTC_1190 1486-1332 13 µM -0.284822267508884 0.38664898153294 no 2099 0.387890155753134 2948 4150046
SGTC_2287 7945887 168.79 µM -0.285052191978099 0.386557046323377 no 2100 0.387802078199946 3006 1245853
SGTC_1255 0566-0045 221 µM -0.286467657697868 0.385991213336317 no 2101 0.387259980681107 3057 2788469
SGTC_987 1497-1013 404 µM -0.286730299390605 0.385886248845915 no 2102 0.387159417852225 2910 1676435
SGTC_2231 micatex 6.853 µM -0.288362577400139 0.385234098142912 no 2103 0.386534605256559 2945 20737 An antifungal of unknown mechanism.
SGTC_309 k408-0051 1.48 µM -0.289014222254897 0.384973834320589 no 2104 0.38628524699428 2945 3640463
SGTC_957 1187-1561 14.1 µM -0.289676909894847 0.384709213201698 no 2105 0.386031711261808 2908 1538454
SGTC_356 1634-0012 32.5 µM -0.290039664519048 0.384564382572754 no 2106 0.385892946631913 3036 735457
SGTC_3202 9113761 49.47 µM -0.290088607223744 0.384544843316863 no 2107 0.385874225682481 3073 4798415
SGTC_666 0272-0154 136 µM -0.290472887116077 0.384391438551491 no 2108 0.385727244998238 2958 6870312
SGTC_308 4092-1169 104 µM -0.2930690174207 0.383355537203982 no 2109 0.384734699020636 2940 2268590 YDL196W YDL196W
SGTC_39 0986-0283 58.349 µM -0.293673768492128 0.383114350364031 no 2110 0.384503600298694 3097 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_374 0880-0231 82.3 µM -0.29462624096595 0.382734577161611 no 2111 0.384139707058905 3002 6833587
SGTC_2794 7785382 27.27 µM -0.294837247250481 0.382650459227124 no 2112 0.384059105661882 2985 2205081
SGTC_2680 butyl paraben 22.24 µM -0.295186203044857 0.382511359687186 no 2113 0.383925820520472 2924 7184 An antifungal and steroid mimetic.
SGTC_843 0310-0051 143 µM -0.295879890653169 0.382234889384879 no 2114 0.38366090439065 2973 2065037
SGTC_1118 chelidonine 707.474 nM -0.298011034021862 0.381385894858478 no 2115 0.382847371059834 3064 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_152 4469-0003 551.229 µM -0.298800926635203 0.381071365963348 no 2116 0.382545971935064 2910 697280
SGTC_2182 6325192 200 µM -0.298888015001796 0.381036692879428 no 2117 0.382512745999295 2940 736248
SGTC_2160 5660466 132.927 µM -0.299910113845672 0.380629829168166 no 2118 0.382122859757259 2991 2859134
SGTC_3106 9121286 49.47 µM -0.300739941609392 0.380299599265574 no 2119 0.381806404442755 3137 15943471
SGTC_247 mechlorethamine 29.705 µM -0.3008132537222 0.380270428905244 no 2120 0.381778450618062 2924 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.301698805893258 0.379918127925172 no 2121 0.381440839325435 3011 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1352 1496-0991 99 µM -0.30171810779806 0.379910450118457 no 2122 0.381433481596948 2924 3000039
SGTC_1852 st056254 31.4 µM -0.301818647441012 0.37987045877155 no 2123 0.381395157399014 2920 442583
SGTC_2215 7188065 200 µM -0.301964094697121 0.379812606934043 no 2124 0.381339717153355 3058 940217
SGTC_1016 4226-1401 38 µM -0.30280035589182 0.379480035172129 no 2125 0.381021006090465 2933 2901613
SGTC_690 glyoxal 20.3 µM -0.303075302172973 0.379370711560871 no 2126 0.380916237759882 2965 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_297 0986-0032 24 µM -0.303561186511576 0.379177538752518 no 2127 0.380731112793989 2917 2847425
SGTC_1181 1222-0449 220 µM -0.305142015953403 0.378549258095509 no 2128 0.380128996036882 3119 658318
SGTC_1889 st059080 5.18 µM -0.305162146025988 0.378541259718532 no 2129 0.380121330631365 3113 176925 Isolated from Daphnopsis sellowiana.
SGTC_1006 4099-6547 255 µM -0.306232975369018 0.378115857111996 no 2130 0.379713633473625 3032 3146833
SGTC_1079 idarubicin 2.36 µM -0.306260604137032 0.37810488313287 no 2131 0.379703116132108 3064 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3118 9124250 49.47 µM -0.306824441795018 0.377880951728115 no 2132 0.379488501574219 2994 1504786
SGTC_2191 5911152 200 µM -0.307553303938185 0.377591540697142 no 2133 0.379211128467632 2995 2875902
SGTC_1921 5740136 50 µM -0.308466112152388 0.377229186688434 no 2134 0.378863841219243 3146 1774243
SGTC_775 4577-0580 57.3 µM -0.311201836827777 0.376143844918826 no 2135 0.377823593367886 3146 2006902
SGTC_887 0885-0007 9.62 µM -0.311959309098485 0.375843506237565 no 2136 0.377535723897701 3079 5719458
SGTC_156 3474-0145 5.642 µM -0.313313879191039 0.375306605125699 no 2137 0.377021103268995 2934 2265471
SGTC_2876 9059903 25.97 µM -0.313684925597727 0.375159578241294 no 2138 0.376880175474396 2929 6916095
SGTC_1553 gossypol 38.6 µM -0.315172283496953 0.374570395952305 no 2139 0.376315424255874 2931 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1653 st012112 65 µM -0.315714798181181 0.374355564143827 no 2140 0.376109496729169 3129 720429
SGTC_3198 9112019 49.47 µM -0.316388544533809 0.374088819867252 no 2141 0.375853805436461 2941 45595555
SGTC_1987 st072290 61.9 µM -0.316939625635646 0.373870685044021 no 2142 0.375644706949048 3013 54697379
SGTC_2957 9076800 11.52 µM -0.31871246391853 0.373169215497353 no 2143 0.374972281168018 3000 16459615
SGTC_679 0422-0091 41.4 µM -0.319156590834942 0.372993550866225 no 2144 0.37480388620132 2968 627384 YHR062C RPP1
SGTC_547 1120-0019 610 nM -0.32031037650896 0.37253731979765 no 2145 0.374366528949018 2931 3676939
SGTC_1996 st072960 66.8 µM -0.321076281492333 0.372234563585973 no 2146 0.37407629205696 3098 1719405
SGTC_107 0358-0022 2.6945 µM -0.321079643536285 0.372233234770383 no 2147 0.37407501817991 3054 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1897 st060201 15 µM -0.321418060577116 0.372099486470737 no 2148 0.373946799142196 2980 611878
SGTC_1578 josamycin 24.2 µM -0.322271604808051 0.371762219514797 no 2149 0.373623471314378 2990 5282165 A P450 substrate.
SGTC_1684 st024538 14.6195 µM -0.322914522167086 0.371508243995647 no 2150 0.373379988953253 2984 6732859
SGTC_1644 st010134 20.9 µM -0.323517120957004 0.371270246536616 no 2151 0.373151821720248 3088 3818134
SGTC_337 1315-0038 354 µM -0.32423134237373 0.370988227264421 no 2152 0.372881447443161 2992 1626437
SGTC_2214 7179297 48.276 µM -0.324902362796352 0.370723329561303 no 2153 0.372627484287075 2993 769744
SGTC_623 k072-0108 16.9 µM -0.326224496483392 0.370201572263096 no 2154 0.372127254399223 3037 5382803
SGTC_950 1165-0508 94.1 µM -0.326682185315532 0.370021008825988 no 2155 0.371954137841013 3054 6148369
SGTC_2324 6149169 200 µM -0.327636120601383 0.369644762647156 no 2156 0.371593403888905 3038 2888231
SGTC_507 nimesulide 162 µM -0.328471813245101 0.369315255634537 no 2157 0.371277476428154 3172 4495 A COX2 inhibitor.
SGTC_766 1391-0721 126 µM -0.330183470870731 0.368640662403482 no 2158 0.370630667738971 3136 1020919 YIL115C NUP159
SGTC_984 1492-0255 2.91 µM -0.331555224428943 0.368100323055527 no 2159 0.370112567205119 3091 1585198
SGTC_1814 st052110 31.539 µM -0.331897401972326 0.367965578525683 no 2160 0.369983366115606 3131 674163
SGTC_2712 st079126 47.7 µM -0.33578087177261 0.366437466772752 no 2161 0.368518057827034 2981 3152970
SGTC_1362 1611-0397 101 µM -0.339761190044655 0.364873440573058 no 2162 0.367018188436597 3022 27816
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.341040546385333 0.364371205990591 no 2163 0.366536528951203 3064 66535 A nucleotide analog.
SGTC_827 3253-0474 693 µM -0.341842205925221 0.364056618536176 no 2164 0.366234822556851 3139 5402065
SGTC_2105 5350118 200 µM -0.343942866911032 0.363232711493846 no 2165 0.365444626578849 3028 2133313
SGTC_3285 9112818 20.8695 µM -0.34402517257721 0.363200442972546 no 2166 0.365413677633679 2994 17017947 YPR165W RHO1
SGTC_1028 k015-0029 4.8 µM -0.344368132876877 0.363065993404411 no 2167 0.365284725601627 2992 4588309
SGTC_531 3788-1495 174 µM -0.346090115180053 0.362391185853706 no 2168 0.364637495942218 2959 2896655
SGTC_1219 1469-0211 33.1 µM -0.346421166454538 0.36226150294383 no 2169 0.364513110114394 3135 6822282
SGTC_405 ebelactone b 50 µM -0.346624413077395 0.362181892855254 no 2170 0.364436751368437 3019 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3115 9123671 49.47 µM -0.347475021672117 0.361848780935374 no 2171 0.364117240345379 3110 3286988
SGTC_2819 7996655 46.38 µM -0.3477134148529 0.361755441118392 no 2172 0.364027710510072 3062 6456960
SGTC_2961 9083290 32.55 µM -0.349755257263869 0.360956321097146 no 2173 0.363261190106179 3088 17741490
SGTC_221 trifluoperazine 10.304 µM -0.350308964952667 0.360739719792908 no 2174 0.36305341897851 3053 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.350833984121031 0.360534382215674 no 2175 0.362856450038686 3133 1377
SGTC_1399 3562-5772 25 µM -0.351599062525842 0.360235228296436 no 2176 0.362569484182466 2965 23847490
SGTC_1280 0880-0253 10.1 µM -0.352567610900011 0.359856638150353 no 2177 0.362206311466134 3030 6836607
SGTC_411 enrofloxacin 100 µM -0.352682372072635 0.359811788935437 no 2178 0.362163288138009 3193 71188 A bacterial gyrase inhibitor.
SGTC_1955 wogonin 32.4 µM -0.353043173355703 0.359670798645458 no 2179 0.362028037080283 3234 5281703 A flavanone.
SGTC_212 3807-4682 38.772 µM -0.35311043134695 0.359644518356515 no 2180 0.362002826451245 3100 3125501 YBL034C STU1
SGTC_1602 st001878 87.6 µM -0.35394281189352 0.35931933017211 no 2181 0.3616908709263 3187 595405 YLR310C CDC25
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.356267293474286 0.35841175928719 no 2182 0.360820200266533 3093 1241132 A phosphatase inhibitor.
SGTC_2921 7974240 10.71 µM -0.356403868479766 0.358358459733659 no 2183 0.360769066355537 3156 2979074 YDR527W RBA50
SGTC_1478 0453-0656 35.7 µM -0.357668919440002 0.357864894156164 no 2184 0.360295547562989 3108 5258496
SGTC_1760 st045453 10.4495 µM -0.359915138698523 0.356989106887437 no 2185 0.359455297807269 3164 3323419 YIL048W NEO1
SGTC_3014 9081533 49.47 µM -0.360266703035313 0.356852102126195 no 2186 0.35932384847701 3167 21367265
SGTC_166 k072-0058 166.424 µM -0.362094904589692 0.356139949233968 no 2187 0.358640555608689 3170 5846229
SGTC_2272 7805186 180 µM -0.362096384251708 0.356139373053062 no 2188 0.358640002765823 3173 2956062 YPR165W RHO1
SGTC_1439 4092-1168 46 µM -0.362244282224007 0.356081783188488 no 2189 0.358584745466255 3107 2886240
SGTC_2560 caryophyllene 100 µM -0.3622448959903 0.356081544201398 no 2190 0.358584516158475 3021 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2084 5306078 60.6385 µM -0.36259880367949 0.355943749752495 no 2191 0.358452302032103 3061 679340
SGTC_205 1486-1330 71.903 µM -0.363734135637714 0.355501833760724 no 2192 0.358028275156454 3056 4118834
SGTC_435 c-PAF 6.7 µM -0.365008775447378 0.355005925054391 no 2193 0.357552427837281 3189 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.365050257412226 0.354989790288403 no 2194 0.357536945544904 3079 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1385 3091-4834 14.1 µM -0.367303245034596 0.354113862732719 no 2195 0.356696416907898 3140 4072814
SGTC_1134 3477-0009 42.5 µM -0.367700902529358 0.353959339465189 no 2196 0.356548133754756 3279 3973534
SGTC_1308 1187-1617 41.4 µM -0.368388575073832 0.353692177811847 no 2197 0.356291757590729 3031 2882570
SGTC_66 0109-0187 42.4 µM -0.370035661067091 0.35305257596049 no 2198 0.355677959816493 3060 759417
SGTC_752 1896-0090 130 µM -0.371014636721802 0.352672613402367 no 2199 0.355313315003731 3036 772567
SGTC_2858 9025781 8.96 µM -0.371268279391248 0.352574192904562 no 2200 0.35521886081545 3142 4894980 YPL153C RAD53
SGTC_23 0213-0011 39.996 µM -0.37198654274133 0.352295540058259 no 2201 0.354951434447997 3228 627608
SGTC_2139 5578692 56.4705 µM -0.372180587910367 0.352220273132501 no 2202 0.354879199112485 3133 650991 YMR113W FOL3
SGTC_1821 st053465 65.6 µM -0.372863710378132 0.351955347248869 no 2203 0.354624941181947 3126 675086
SGTC_2799 7812892 81.82 µM -0.374799030911753 0.351205189304864 no 2204 0.353904967522024 3219 20205235
SGTC_3307 9126885 69.2785 µM -0.37649051664392 0.35055001954377 no 2205 0.35327613219604 3054 24824909
SGTC_3282 9108498 15.4605 µM -0.378494742760934 0.34977429003764 no 2206 0.352531549241395 3153 16459645
SGTC_463 ikarugamyin 104 µM -0.378592624199474 0.349736421355552 no 2207 0.352495200094237 3137 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_285 1486-1325 46 µM -0.379620359649951 0.349338898114017 no 2208 0.352113622725335 3181 22310230
SGTC_947 3447-0010 211 µM -0.381208724427593 0.348724851172745 no 2209 0.351524187938535 3130 748350
SGTC_248 streptozotocin 5.23457 mM -0.381586631749896 0.348578814009083 no 2210 0.35138400078319 3160 5300 DNA alkylating agent.
SGTC_692 k241-0027 77.8 µM -0.382055689219973 0.348397584315386 no 2211 0.351210029010856 3241 3600480
SGTC_3095 9117207 49.47 µM -0.383112751812195 0.347989294048308 no 2212 0.350818082536626 3165 17015229
SGTC_1369 1866-0067 208 µM -0.383121577672435 0.347985885802079 no 2213 0.350814810678161 3219 3531355
SGTC_3220 9131269 49.47 µM -0.383621635816766 0.347792800467431 no 2214 0.350629450851717 3147 17722206
SGTC_536 3852-0578 10.6 µM -0.383841388104756 0.347707960927057 no 2215 0.350548005075467 3224 2869208
SGTC_63 0099-0242 26.702 µM -0.384487351279098 0.347458618755053 no 2216 0.350308634514141 3199 3898502 YLR359W ADE13
SGTC_1937 st074714 47.2 µM -0.384886246959027 0.347304677733761 no 2217 0.350160847902025 3047 17250970
SGTC_223 busulfan 5 mM -0.385266428131965 0.347157982418363 no 2218 0.350020015931858 3170 2478 A DNA alkylator.
SGTC_891 0929-0073 133 µM -0.385842864108121 0.34693560462826 no 2219 0.349806523893722 3203 5603632
SGTC_1384 3089-0840 101 µM -0.386693867387622 0.346607400477044 no 2220 0.349491428384042 3197 1069836
SGTC_2504 purpurogallin 52.29 µM -0.386907392239373 0.346525068974268 no 2221 0.349412384173021 3057 5281571 An antioxidant.
SGTC_2283 7944793 200 µM -0.388267752688004 0.346000707793764 no 2222 0.348908949319027 3156 2970533
SGTC_3163 9099914 49.47 µM -0.389961104005707 0.345348405229593 no 2223 0.348282654498981 3168 16268368
SGTC_350 k064-0020 19.8 µM -0.390093246977729 0.34529752119856 no 2224 0.348233798101816 3259 2790705
SGTC_709 3807-1509 243 µM -0.39019472927579 0.345258445510421 no 2225 0.348196279394115 3145 1886677 YPL242C IQG1
SGTC_1449 4112-4002 201 µM -0.391202097398703 0.344870648632475 no 2226 0.347823929050212 3132 2059539
SGTC_604 1000-0114 314 µM -0.391423038210667 0.344785616929192 no 2227 0.347742282991422 3226 1572745
SGTC_2291 7917025 104.35 µM -0.392516572060248 0.344364872902264 no 2228 0.34733828453571 3031 2964612
SGTC_2674 ligustilide 100 µM -0.394348558337068 0.34366043630227 no 2229 0.346661858700603 3171 5319022 A signalling regulator.
SGTC_2766 oltipraz 83.91 µM -0.395493622481934 0.343220410824671 no 2230 0.34623931366976 3227 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3063 1327-0034 4 µM -0.395888876985023 0.34306857164403 no 2231 0.346093503503032 3184 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1678 st019265 80.2 µM -0.396323878073178 0.342901492881726 no 2232 0.345933057114076 3302 5367020
SGTC_102 gallobenzophenone 83.616 µM -0.397102752311426 0.342602413273757 no 2233 0.345645845202511 3278 70837
SGTC_1192 1488-0095 21.4 µM -0.397207516429165 0.34256219246459 no 2234 0.345607219933832 3177 915875
SGTC_2881 9058953 51.95 µM -0.400451755991731 0.341317556673586 no 2235 0.344411905183541 3068 17122249
SGTC_2831 7999036 19.48 µM -0.40265215457867 0.340474365380203 no 2236 0.343602068088662 3314 2988270
SGTC_750 4073-0104 132 µM -0.403089746007465 0.340306775481155 no 2237 0.3434411018536 3150 22330957
SGTC_1345 1488-0192 31.4 µM -0.404203546342925 0.339880351696243 no 2238 0.343031523064326 3250 658348
SGTC_338 4055-0136 114 µM -0.404447083977151 0.339787139415406 no 2239 0.342941991300052 3106 2900563
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.40819268537438 0.338354774270245 no 2240 0.341566108935215 3170 97141
SGTC_58 0957-0393 9 µM -0.408770077784763 0.338134179424738 no 2241 0.341354200333368 3249 6997992
SGTC_269 exalamide 29 µM -0.411113338987417 0.337239499023626 no 2242 0.340494714717899 3125 3316 A derivative of salicylamide.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.411317438633757 0.337161615219585 no 2243 0.340419892059836 3244 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_991 3996-0057 64.7 µM -0.41178800079415 0.3369820767282 no 2244 0.340247408538316 3189 715343
SGTC_3183 9108214 49.47 µM -0.413872159901246 0.336187332670008 no 2245 0.33948386684908 3203 4974831
SGTC_770 0389-1121 67.2 µM -0.413922447420925 0.336168165756554 no 2246 0.339465451897761 3291 6753108
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.414008057536583 0.336135536738068 no 2247 0.339434102931226 3162 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1681 tripelennamine 100 µM -0.416310957590401 0.335258284704035 no 2248 0.338591237700834 3217 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1353 1498-1206 8.11 µM -0.416322077059516 0.335254051098403 no 2249 0.338587169913123 3201 6756808
SGTC_2159 5658611 73.75 µM -0.416645795632011 0.335130808275591 no 2250 0.338468753591618 3254 793844
SGTC_921 1561-0023 372 µM -0.418675997791904 0.334358295592667 no 2251 0.337726469779667 3105 24050882
SGTC_214 4373-3496 70 µM -0.420149394111302 0.333798091944049 no 2252 0.337188160468 3250 3779166
SGTC_1980 st071811 45.7 µM -0.420900627041381 0.333512606251732 no 2253 0.33691382366248 3291 4974850
SGTC_1864 st057645 30.4 µM -0.421585873836467 0.333252280853913 no 2254 0.336663659445321 3248 688666
SGTC_2822 7994718 71.43 µM -0.421815518866019 0.333165056620583 no 2255 0.336579838703444 3161 1018011
SGTC_168 3970-0862 530.542 µM -0.422364740793723 0.332956486655391 no 2256 0.336379404903509 3230 3135186
SGTC_1226 3909-7979 35.4 µM -0.422492849869876 0.332907843977685 no 2257 0.336332659287265 3260 6615510
SGTC_1484 3473-2379 286 µM -0.422798993594547 0.332791613404147 no 2258 0.336220961001837 3273 671917
SGTC_655 k060-0012 42 µM -0.423366374790819 0.33257624386162 no 2259 0.336013986965181 3147 5994525
SGTC_2226 7298446 200 µM -0.423733240347246 0.332437016508854 no 2260 0.335880185152925 3245 3283010
SGTC_2701 st077767 14.721 µM -0.424198699916215 0.332260405495016 no 2261 0.335710454442402 3183 5721188
SGTC_2669 eugenol 100 µM -0.425691653937717 0.331694180004485 no 2262 0.335166272202804 3209 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1498 4478-3555 97.6 µM -0.425715183342484 0.331685259193223 no 2263 0.33515769849171 3227 3437919
SGTC_1572 epiandrosterone 68.9 µM -0.425861064054948 0.331629952899535 no 2264 0.335104543981849 3139 441302 A steroid.
SGTC_1848 st056003 16.4 µM -0.426598244774503 0.33135052911048 no 2265 0.334835988195983 3259 146492
SGTC_2884 9058502 51.95 µM -0.427024309338099 0.33118907476442 no 2266 0.33468081088266 3248 6471554
SGTC_3295 9122362 53.5725 µM -0.427871820246664 0.330868009425333 no 2267 0.334372222211469 3245 4730473
SGTC_2005 4024620 188 µM -0.429416260270686 0.330283244081764 no 2268 0.333810161310532 3173 236743
SGTC_796 1234-0020 70.7 µM -0.429767199446 0.330150427049473 no 2269 0.333682497560548 3175 46495034
SGTC_49 0717-0965 32.132 µM -0.429997328305609 0.330063343710189 no 2270 0.333598792327602 3403 5889349 YGL099W LSG1
SGTC_2811 7967822 32.47 µM -0.430516492752014 0.329866919885118 no 2271 0.333409986024446 3292 2232244
SGTC_3218 9131285 49.47 µM -0.431176038299635 0.329617451069845 no 2272 0.333170187705241 3343 17156417
SGTC_2677 mitomycin C 100 µM -0.432125352467764 0.329258512237926 no 2273 0.332825154703243 3185 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_471 1-acyl-paf 4 µM -0.43263638287727 0.329065355060738 no 2274 0.332639476711018 3160 16759367
SGTC_3208 9114115 49.47 µM -0.433008264135542 0.328924821589826 no 2275 0.332504383028091 3221 650895
SGTC_3060 1327-0027 12.5 µM -0.433088426473151 0.328894531508166 no 2276 0.332475265223445 3193 16000455 YPR107C YTH1
SGTC_1674 st016616 23.6 µM -0.433336733662246 0.328800713469227 no 2277 0.332385077659974 3109 625830
SGTC_2471 5466956 24.79 µM -0.436245444501384 0.327702518314202 no 2278 0.331329329673363 3142 724419
SGTC_1167 k781-0610 148 µM -0.437664839745865 0.327167159928495 no 2279 0.330814630460947 3192 4525169
SGTC_2493 resveratrol 26.09 µM -0.440826307820705 0.325976016277458 no 2280 0.329669373199784 3197 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2564 betulinic acid 100 µM -0.440991378686876 0.325913871288688 no 2281 0.329609619205681 3411 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1166 k206-0078 225 µM -0.442217788805083 0.325452310556465 no 2282 0.329165807365156 3179 5404595
SGTC_195 4234-0266 16.654 µM -0.44398023576548 0.324789480444099 no 2283 0.328528436663023 3187 2303354
SGTC_470 aa-861 153 µM -0.443984685844021 0.324787807536491 no 2284 0.328526827968492 3209 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2063 5246145 200 µM -0.444124618180729 0.324735204903592 no 2285 0.328476244328905 3294 711240
SGTC_2327 6189656 200 µM -0.444387958273204 0.324636220950556 no 2286 0.328381058986486 3268 5349088
SGTC_3029 9088683 49.47 µM -0.445104616744632 0.324366906965958 no 2287 0.32812207629877 3302 25236615
SGTC_1998 st075797 76.8 µM -0.446055011032139 0.324009898779305 no 2288 0.32777875467401 3304 24208315
SGTC_174 3553-0389 74.3 µM -0.44706567449356 0.323630428463142 no 2289 0.327413820989964 3314 738071
SGTC_2666 tannic acid 100 µM -0.44707283374785 0.323627741056103 no 2290 0.327411236490563 3297 16134267 A thiamine antagonist.
SGTC_1879 gemcitabine 100 µM -0.447223601529304 0.323571148695461 no 2291 0.32735681106188 3189 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1547 harmine 94.2 µM -0.448258250405946 0.323182891889757 no 2292 0.326983413813771 3233 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1140 3229-1848 2.98 µM -0.448731371982604 0.323005414938893 no 2293 0.32681272534924 3286 2849525
SGTC_929 2805-0021 398 µM -0.450009976624579 0.322525987551376 no 2294 0.326351623453839 3268 3098024
SGTC_1561 5-methoxyflavone 52.9 µM -0.450637384118798 0.322290841783315 no 2295 0.326125459095162 3256 94525
SGTC_2963 9082507 9 µM -0.452046140176843 0.321763113892205 no 2296 0.325617871613631 3314 16459611
SGTC_409 arachidonic acid 100 µM -0.453592323571181 0.321184318601035 no 2297 0.325061139818912 3210 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2948 9070189 9.45 µM -0.45406375126048 0.321007931563063 no 2298 0.324891471198522 3289 6473636 YDL196W YDL196W
SGTC_2142 5622915 118.518 µM -0.454958336302718 0.320673329126206 no 2299 0.324569606499882 3234 5322196
SGTC_2845 9003024 42.97 µM -0.455869047094921 0.3203328447677 no 2300 0.32424207441838 3395 2990173
SGTC_1886 st057356 49.9 µM -0.456764298134949 0.319998287648282 no 2301 0.323920234859154 3186 24207747
SGTC_2434 5670830 169.91 µM -0.458900827939253 0.319200453864819 no 2302 0.323152692097343 3281 1549830
SGTC_2480 5767542 37.17 µM -0.460115798871331 0.318747126152562 no 2303 0.322716552266662 3202 2867358
SGTC_2365 9042475 200 µM -0.462023034765646 0.318036048775419 no 2304 0.322032400933128 3298 6464479
SGTC_2676 harmalol 100 µM -0.462989624363692 0.317675929595199 no 2305 0.321685902124015 3310 5459187 A monoamine oxidase inhibitor
SGTC_2872 9044037 25.97 µM -0.463212759845912 0.31759282121015 no 2306 0.321605935508728 3223 6465195
SGTC_521 r062-0005 13.8 µM -0.464567001157112 0.317088621780566 no 2307 0.321120784037118 3251 2832033
SGTC_2842 9000675 19.48 µM -0.464730637943762 0.317027720909528 no 2308 0.3210621824688 3254 2989072
SGTC_52 0329-0193 875 nM -0.465261677483713 0.316830117524773 no 2309 0.320872037414248 3402 3739292
SGTC_1487 3970-0795 2.82 µM -0.465327048852164 0.316805796009276 no 2310 0.320848633660741 3302 3765103
SGTC_765 1319-0117 244 µM -0.465687204502337 0.316671813760039 no 2311 0.320719706278219 3211 3487746 YGL099W LSG1
SGTC_1809 st050081 57.6 µM -0.466053395475916 0.316535610952574 no 2312 0.320588640558157 3380 5036894
SGTC_1126 isoteolin 1.0172 µM -0.466505136532365 0.316367622514167 no 2313 0.32042698588467 3203 133323
SGTC_1108 betulinic acid 729.144 nM -0.466767170004572 0.316270197780578 no 2314 0.320333233315692 3257 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3182 9108849 49.47 µM -0.467400174118874 0.316034897811007 no 2315 0.320106799024619 3323 17133045
SGTC_1506 4226-2149 212 µM -0.467527365285147 0.315987627360899 no 2316 0.320061309072035 3297 991114
SGTC_1074 carmofur 3.8 µM -0.470548073536602 0.314865870212473 no 2317 0.318981748259502 3275 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_157 1348-1695 65.819 µM -0.47226869015287 0.314227671306413 no 2318 0.318367507822313 3312 5380510
SGTC_444 curcumin 90.4 µM -0.472833532007322 0.314018285081694 no 2319 0.318165974453743 3339 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3166 9102297 49.47 µM -0.474453851639675 0.313417966793135 no 2320 0.317588149530845 3284 25237072
SGTC_105 0111-0055 734.78 µM -0.474899997313041 0.313252759272138 no 2321 0.317429126682903 3292 5179370
SGTC_2181 6316240 54.2555 µM -0.475535859084897 0.313017364740691 no 2322 0.317202540218363 3303 12779990
SGTC_1159 4092-0538 61.2 µM -0.476470838987252 0.312671375792026 no 2323 0.316869488802941 3266 717301
SGTC_2254 7938975 95.19 µM -0.476574273866515 0.312633109886626 no 2324 0.316832653127316 3414 2969277
SGTC_3261 9137475 49.47 µM -0.476990381383224 0.312479190627627 no 2325 0.316684485470677 3228 17027690
SGTC_3320 9137005 35.139 µM -0.477468611866 0.312302332317853 no 2326 0.316514233373864 3272 4908713
SGTC_962 1254-0300 21.5 µM -0.478742447048649 0.311831456002807 no 2327 0.316060932346763 3240 7340576
SGTC_2258 7960471 200 µM -0.479747521983904 0.311460144491308 no 2328 0.315703466102177 3275 2974708
SGTC_1953 st076800 12.1 µM -0.480004506813245 0.311365235635394 no 2329 0.315612094199247 3254 297591
SGTC_1840 st055363 71 µM -0.480845429403347 0.311054756314589 no 2330 0.315313179878449 3280 676033
SGTC_2412 st077135 33.4 µM -0.484532347434601 0.309695088224356 no 2331 0.314004056628835 3463 13258915
SGTC_2122 5258151 111.688 µM -0.485458684770864 0.309353879857124 no 2332 0.313675506450395 3261 2173356
SGTC_1024 4507-0395 26 µM -0.486497329689345 0.308971499367888 no 2333 0.313307299074741 3409 4201836
SGTC_262 fenpropimorph 62.5 µM -0.489211222873929 0.307973348265937 no 2334 0.312346082432309 3308 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3354 9151612 71.43 µM -0.490932338701332 0.307341068521685 no 2335 0.311737151838233 3370 27261949
SGTC_2004 4023728 41.89 µM -0.491080159026282 0.307286790989078 no 2336 0.311684876986264 3394 360084 YDR527W RBA50
SGTC_2874 9043904 71.43 µM -0.493640905891038 0.306347191697531 no 2337 0.310779903133045 3282 4463428
SGTC_1702 st027038 51 µM -0.494610389125682 0.305991796700798 no 2338 0.31043758362288 3329 5521182
SGTC_1471 k673-0312 37 µM -0.495609201620304 0.305625841046931 no 2339 0.310085079736056 3339 24099884
SGTC_1059 3448-6867 171 µM -0.497123122061266 0.305071524686203 no 2340 0.309551115109037 3360 3934407
SGTC_1135 dihydrocapsaicin 536.708 nM -0.497872930282078 0.304797150584142 no 2341 0.309286804020684 3276 107982 A Capsaicinoid.
SGTC_2795 7780010 54.55 µM -0.498648028807687 0.304513637462231 no 2342 0.309013681675314 3371 953673
SGTC_2451 5856223 45.7 µM -0.498666306666659 0.304506953260316 no 2343 0.309007242358715 3290 2179896
SGTC_3325 9138760 55.175 µM -0.498760578868367 0.304472479010241 no 2344 0.308974031055442 3257 43844959
SGTC_792 4534-1957 155 µM -0.499464164317642 0.304215240852661 no 2345 0.308726213155055 3276 1717904
SGTC_922 1866-0035 480 µM -0.501663064056976 0.303411925073998 no 2346 0.307952275171598 3268 3156169
SGTC_2661 dactinomycin 12.96 µM -0.502879474911671 0.302967945829119 no 2347 0.307524506276079 3305 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_866 0495-0101 262 µM -0.502897757896466 0.302961274919103 no 2348 0.307518078787898 3267 635694
SGTC_2021 4019055 173 µM -0.503803171921845 0.302630998908491 no 2349 0.307199849255717 3435 44827708 YER133W GLC7
SGTC_570 0987-0065 62.6 µM -0.504196134887746 0.302487704501033 no 2350 0.307061778122595 3279 3104428
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.50738791114253 0.301324948340868 no 2351 0.305941333100942 3275 4174840
SGTC_1713 st033146 12.748 µM -0.507711997688845 0.301206997047077 no 2352 0.305827666616688 3431 674619
SGTC_699 0375-0592 111 µM -0.508254131353164 0.301009734018922 no 2353 0.30563756654151 3415 762578
SGTC_3156 9099931 49.47 µM -0.510180188900825 0.300309382119311 no 2354 0.30496261508939 3250 18111053
SGTC_2892 9047358 58.44 µM -0.511722504843787 0.29974909767501 no 2355 0.304422616688126 3296 6466771
SGTC_1695 st026914 34.495 µM -0.512364322635205 0.299516081049282 no 2356 0.3041980277758 3323 3289191
SGTC_2029 5175081 200 µM -0.513743877907281 0.299015501582577 no 2357 0.303715535161714 3334 1380876
SGTC_3020 9089140 49.47 µM -0.515009251859643 0.29855668778401 no 2358 0.303273277452596 3405 17217859
SGTC_2037 5169046 200 µM -0.515229911583586 0.298476711251603 no 2359 0.303196184707574 3393 5718022
SGTC_1494 4358-1428 177 µM -0.51580033742183 0.298270009686105 no 2360 0.302996933435576 3430 1564571
SGTC_304 1310-0298 97 µM -0.518556348748735 0.297272250961275 no 2361 0.302035077910342 3370 1550234
SGTC_3110 9122132 49.47 µM -0.519428767783813 0.296956727233508 no 2362 0.301730887255427 3481 918317
SGTC_1648 st011736 69.8 µM -0.519657821912006 0.296873911694627 no 2363 0.301651044655884 3449 2855514
SGTC_1197 1601-0112 267 µM -0.521077851864755 0.296360729586849 no 2364 0.301156269560505 3298 7350313
SGTC_2720 fluspirilene 36.88 µM -0.521656988408806 0.296151553279 no 2365 0.300954588459834 3376 3396 An atypical antipsychotic.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.522875181206019 0.295711779723425 no 2366 0.300530558456252 3418 6708760
SGTC_2472 5377652 49.4 µM -0.523143570035748 0.29561493039988 no 2367 0.30043717363232 3369 1610903
SGTC_1015 4130-4525 82 µM -0.523229367149817 0.295583973199002 no 2368 0.300407323633615 3294 1363237
SGTC_587 k089-0003 57 µM -0.523534261619912 0.295473973641905 no 2369 0.300301257487524 3386 9659696
SGTC_662 k832-1615 104 µM -0.523864994822782 0.295354673302283 no 2370 0.300186221751294 3370 5878478
SGTC_2937 9044753 11.33 µM -0.524502114581274 0.295124917310745 no 2371 0.299964674720224 3347 6465530 YGL099W LSG1
SGTC_1587 estradiol valerate 56.1 µM -0.526044772438369 0.294568950387239 no 2372 0.29942854969559 3435 13791 A steroid.
SGTC_1229 0139-0193 12.2 µM -0.526903126624824 0.294259812811835 no 2373 0.299130431256585 3450 3090752
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.529297934406728 0.293398112412684 no 2374 0.298299394140801 3426 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1851 st056236 18.9 µM -0.530595327487323 0.292931772851178 no 2375 0.297849617139168 3463 5393171
SGTC_45 0kpi-0036 14.9 µM -0.532204714317265 0.292353767631532 no 2376 0.297292109094733 3428 2795021
SGTC_1917 st066507 28.5 µM -0.532632843679004 0.292200095937927 no 2377 0.297143881042663 3280 3156428
SGTC_1443 4112-3303 14 µM -0.534127622076521 0.291663858769506 no 2378 0.296626620132246 3382 704433
SGTC_901 1112-0062 60.1 µM -0.534417024764568 0.29156009140501 no 2379 0.296526521391227 3368 1908457
SGTC_1929 genistein trimethyl ether 50.5 µM -0.535350320716377 0.29122556892447 no 2380 0.296203818026996 3469 136420
SGTC_703 3875-0075 71.8 µM -0.535650288902564 0.291118089000591 no 2381 0.296100133012258 3395 2850814
SGTC_2751 anetholtrithion 17.25 µM -0.535894821509419 0.291030485597696 no 2382 0.296015621817245 3415 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2976 9009005 19.48 µM -0.538137468271875 0.290227636078095 no 2383 0.295241073389671 3455 2993148
SGTC_719 2810-4230 27.3 µM -0.538199121248307 0.290205579469041 no 2384 0.295219793331078 3370 721079
SGTC_2257 7960413 200 µM -0.538200417284374 0.290205115815169 no 2385 0.295219346000586 3368 2974689 YIL048W NEO1
SGTC_2816 7982706 58.44 µM -0.539054188592435 0.289899756570872 no 2386 0.294924732264764 3387 2981853
SGTC_1228 0124-0032 52.5 µM -0.539473029101811 0.289750009484786 no 2387 0.294780251115622 3432 X1228
SGTC_3206 9114350 49.47 µM -0.539621208004951 0.289697040114838 no 2388 0.294729143870605 3389 17087243
SGTC_103 0844-0104 51.839 µM -0.541361445586009 0.289075299421133 no 2389 0.294129237937943 3466 5375804
SGTC_2482 5981709 142.65 µM -0.541685040630112 0.288959756736573 no 2390 0.294017748414929 3355 877755
SGTC_2697 mebhydrolin 72.4 µM -0.542000064385487 0.288847295389719 no 2391 0.293909230764351 3466 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2740 felodipine 17.08 µM -0.542100908906261 0.28881129893242 no 2392 0.29387449631282 3381 3333 L-type calcium channel blocker
SGTC_209 4077-0173 175.592 µM -0.542576847113344 0.28864144127082 no 2393 0.293710591842577 3378 15993494
SGTC_2121 5257820 149.641 µM -0.544017708859706 0.288127498959457 no 2394 0.293214643343789 3470 791256
SGTC_3046 9092212 49.47 µM -0.54527774123204 0.287678411055403 no 2395 0.292781255283401 3410 25236637
SGTC_290 2043-6722 48.1 µM -0.546306230839732 0.287312092634137 no 2396 0.292427726963661 3435 773758 YLR208W SEC13
SGTC_1625 st003711 30.1 µM -0.546846321206696 0.287119816399353 no 2397 0.292242158272306 3501 24207034 YER133W GLC7
SGTC_801 0866-0028 10.1 µM -0.547801911785493 0.286779768298514 no 2398 0.291913962875704 3417 6849771
SGTC_2219 9098279 200 µM -0.548849171813078 0.286407318903568 no 2399 0.291554481086535 3439 902349
SGTC_2984 9022109 38.96 µM -0.551044888340219 0.285627176544774 no 2400 0.290801451764732 3507 6459207
SGTC_40 0327-0103 19.753 µM -0.551260157830085 0.285550745338224 no 2401 0.29072767324726 3343 409036
SGTC_2895 9054447 58.44 µM -0.552280158924555 0.285188727425171 no 2402 0.290378211095914 3415 2697450
SGTC_2123 5259487 200 µM -0.552361305715153 0.285159936270935 no 2403 0.290350417875663 3430 2173474
SGTC_79 0052-0007 94.094 µM -0.553148057044425 0.284880866103493 no 2404 0.290081015843967 3503 2801472
SGTC_438 sphingosine 6.67 µM -0.553390656124116 0.284794839578591 no 2405 0.289997967891826 3280 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1046 2001-0062 216 µM -0.556045385784756 0.283854273655651 no 2406 0.289089914364306 3401 739778
SGTC_2557 derrustone 83.84 µM -0.557270218418016 0.283420819526364 no 2407 0.288671410151186 3471 629853 An antioxidant.
SGTC_3240 9133527 49.47 µM -0.557750433063862 0.283250963737534 no 2408 0.288507406980464 3416 17617455
SGTC_2381 9035592 200 µM -0.55832839720937 0.283046597931858 no 2409 0.288310078590007 3405 4749657
SGTC_457 grayanotoxin iii 135 µM -0.558667994801832 0.282926550602201 no 2410 0.288194162947 3444 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2648 atorvastatin 78.68 µM -0.559292357604468 0.282705902937057 no 2411 0.28798110511282 3482 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1911 st060208 74.3 µM -0.560676958192055 0.28221688506853 no 2412 0.287508888882371 3439 688783
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.561181412701169 0.28203882137585 no 2413 0.287336936369717 3395 688667
SGTC_2297 7971671 152.32 µM -0.562454653405623 0.281589630259534 no 2414 0.286903145593882 3503 909016
SGTC_1710 st031758 61.5 µM -0.562663051571547 0.281516141600758 no 2415 0.286832174281574 3507 5394341
SGTC_1751 st044839 27.194 µM -0.565760529850551 0.280424951922487 no 2416 0.285778290643233 3482 5291326
SGTC_2755 lomerizine 42.69 µM -0.565996876031958 0.280341775279681 no 2417 0.285697952082619 3409 3949 A calcium channel blocker.
SGTC_912 3474-0017 2.18 µM -0.566229025650405 0.280260087154054 no 2418 0.285619050475271 3509 3360550
SGTC_2072 5231554 129 µM -0.566303067498184 0.280234035951528 no 2419 0.285593887761343 3523 789545
SGTC_1501 4491-0275 38.4 µM -0.566475035122362 0.280173534648865 no 2420 0.28553544958301 3463 5104718
SGTC_1236 0330-0013 258 µM -0.566485358070945 0.280169903051286 no 2421 0.285531941811303 3391 4617066
SGTC_2815 7968870 71.43 µM -0.567330471204033 0.279872670932292 no 2422 0.285244839206909 3449 2977326 YHR190W ERG9
SGTC_778 3456-2434 196 µM -0.568055911758131 0.279617650531626 no 2423 0.28499850164376 3467 5539063
SGTC_1731 st035964 63 µM -0.568618977684985 0.279419788872453 no 2424 0.284807371523729 3369 6739575
SGTC_1432 4049-0298 68.4 µM -0.569114289482491 0.279245792291399 no 2425 0.284639290811377 3476 741646
SGTC_433 pimozide 108 µM -0.569438554211989 0.279131910844348 no 2426 0.284529279423111 3325 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3215 9129942 49.47 µM -0.570519022203934 0.278752614615355 no 2427 0.284162862039295 3445 17682944
SGTC_1436 4092-1007 8.32 µM -0.571286365811451 0.278483392549915 no 2428 0.28390277113619 3434 2881121
SGTC_1264 0783-0040 158 µM -0.571492100469599 0.278411232204016 no 2429 0.283833056805007 3400 2855798
SGTC_3259 9138485 49.47 µM -0.57178977132777 0.278306841852785 no 2430 0.283732203891064 3626 17646153
SGTC_647 0140-0236 81 µM -0.572009591244296 0.278229765339123 no 2431 0.283657738423699 3462 990837
SGTC_2239 6685329 187.64 µM -0.572967884697635 0.277893875942549 no 2432 0.283333219512207 3480 805680
SGTC_1152 3909-8331 15.9 µM -0.57352257627803 0.277699542663211 no 2433 0.283145458740928 3424 16001939
SGTC_1689 st020265 53.493 µM -0.573962180469226 0.277545576807821 no 2434 0.282996696986953 3500 5758320 YPR016C TIF6
SGTC_3152 9099253 49.47 µM -0.574143600913862 0.277482048734147 no 2435 0.282935315373124 3485 25236131
SGTC_1914 st062367 72.6 µM -0.575281536352592 0.277083739576906 no 2436 0.282550453290467 3417 978205
SGTC_3236 9132701 49.47 µM -0.575667842796384 0.276948585188545 no 2437 0.282419857517013 3444 24282524
SGTC_1093 fluphenazine 7.97 µM -0.575782976074726 0.27690831054167 no 2438 0.282380940874302 3475 6602611 An atypical antipsychotic.
SGTC_3187 9109394 49.47 µM -0.57601882446495 0.276825817628559 no 2439 0.282301228907225 3412 17098090
SGTC_3341 9147222 25.867 µM -0.576592018410244 0.276625381232889 no 2440 0.282107546135926 3483 1939759
SGTC_2175 5807670 165.306 µM -0.577228854744237 0.276402773596944 no 2441 0.281892433598805 3468 241186
SGTC_1293 1000-1278 195 µM -0.577352795138828 0.276359460156683 no 2442 0.281850577819657 3530 678847
SGTC_1768 st044301 37.178 µM -0.581332827652654 0.274970331336019 no 2443 0.280508079936906 3431 3931349
SGTC_1262 0737-0114 49.6 µM -0.581785437898849 0.274812577403325 no 2444 0.280355606969083 3537 765919
SGTC_2316 5844804 197.44 µM -0.582484182411533 0.274569122840927 no 2445 0.280120296413192 3490 776813
SGTC_749 1000-0129 128 µM -0.584219399511098 0.273965004036625 no 2446 0.279536355651627 3543 708470
SGTC_2127 5253358 187.912 µM -0.584415050953839 0.273896928888874 no 2447 0.279470551503446 3421 20612
SGTC_2245 6637752 200 µM -0.585458088664935 0.273534154548955 no 2448 0.279119869916396 3451 681890
SGTC_875 0709-0210 25.7 µM -0.585872300416198 0.273390155390192 no 2449 0.278980666412174 3520 6251364
SGTC_3257 9139206 32.98 µM -0.586368492246323 0.273217705595177 no 2450 0.278813956457045 3479 4910041
SGTC_2589 lobaric acid 100 µM -0.587855601763096 0.272701188718855 no 2451 0.27831460971825 3431 73157 A novel microtubule depolymerizer.
SGTC_216 k038-0035 28.382 µM -0.589590929833275 0.272099071502153 no 2452 0.277732467018116 3467 4444231 YPR107C YTH1
SGTC_2418 pentamidine 31.67 µM -0.591054072249681 0.271591910283362 no 2453 0.277242095735991 3510 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1503 4585-0012 61.3 µM -0.591145502214029 0.271560234037465 no 2454 0.277211467104241 3530 2922052
SGTC_2060 5238662 140 µM -0.59343058940684 0.270769155329861 no 2455 0.276446511175769 3452 790130
SGTC_3018 9082602 49.47 µM -0.593542877396796 0.270730311811392 no 2456 0.276408948340983 3516 17332089
SGTC_2686 alizarin 95.37 µM -0.595744373996863 0.269969315758524 no 2457 0.275673004732935 3442 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1414 3917-0015 5.4 µM -0.596934402342411 0.269558402317011 no 2458 0.27527558876853 3507 6618702
SGTC_1459 k035-0031 35.7 µM -0.597863249050064 0.269237892082638 no 2459 0.27496559181116 3450 3877128 YMR208W ERG12
SGTC_2543 pimpinellin 60.67 µM -0.599146604547665 0.268795368867729 no 2460 0.274537562893309 3420 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2830 7992007 71.43 µM -0.601620061735961 0.267943509800903 no 2461 0.27371353584682 3463 1952075
SGTC_724 3910-0327 137 µM -0.601648651380033 0.267933671476335 no 2462 0.273704018424246 3513 2885483
SGTC_2227 7312221 64.1025 µM -0.601758400992257 0.267895905913521 no 2463 0.273667484567291 3524 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1463 k081-0032 34.1 µM -0.602130614825715 0.267767844655471 no 2464 0.273543598618064 3415 977755
SGTC_1519 esterone 74 µM -0.602355159633323 0.267690604276644 no 2465 0.273468875576925 3442 698 A steroid.
SGTC_1825 st052143 62.6 µM -0.603757290284867 0.267208544397043 no 2466 0.273002509330442 3562 674173
SGTC_1565 sinapyl alcohol 95.1 µM -0.603830772045571 0.26718329306963 no 2467 0.272978079252582 3509 5280507 A phenol propionate derived from cinnamic acid.
SGTC_569 4130-2812 160 µM -0.605221924040532 0.266705463919175 no 2468 0.272515775189812 3461 743552
SGTC_2059 5238311 157 µM -0.605265364031231 0.266690550225523 no 2469 0.272501345584884 3479 703021
SGTC_2313 7726885 200 µM -0.606092638545582 0.266406613183482 no 2470 0.272226619512076 3502 726423
SGTC_2032 5185112 25.99 µM -0.606920586375639 0.266122598258282 no 2471 0.271951807723416 3442 5718189
SGTC_2386 9075165 157.42 µM -0.607503315781049 0.26592279376123 no 2472 0.271758471412115 3495 16452277
SGTC_64 000l-0018 272.079 µM -0.608032282736698 0.265741489006826 no 2473 0.271583031504986 3506 6811119
SGTC_1035 k081-0041 55.2 µM -0.608910802667213 0.265440512619985 no 2474 0.271291781730157 3574 731709
SGTC_1021 4476-0760 85.3 µM -0.610669059059068 0.264838663021981 no 2475 0.270709346831913 3446 746768
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.610881790074353 0.264765892454293 no 2476 0.270638920538135 3518 756377
SGTC_202 3594-0513 34.79 µM -0.612943818100058 0.264061045627398 no 2477 0.26995674434508 3494 708429
SGTC_2114 5491910 81.25 µM -0.61356280084027 0.263849650351559 no 2478 0.269752135714567 3576 2849228
SGTC_2306 7482397 179.52 µM -0.613628880735614 0.26382708781302 no 2479 0.269730297179254 3545 891448
SGTC_1877 wortmannin 25 µM -0.614816123213854 0.263421879492144 no 2480 0.269338080107414 3562 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2549 cedrol 20.94 µM -0.61737656949051 0.262549076602221 no 2481 0.268493186431243 3518 6708665 A sedative which affects the nervous system.
SGTC_376 3970-0862 59.1 µM -0.617833428766819 0.262393498531656 no 2482 0.268342572636744 3535 3135186
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.620062485961572 0.261635096879283 no 2483 0.26760832449111 3545 16486 A toxic proline analog.
SGTC_1278 0874-0585 172 µM -0.620488035095132 0.261490438469477 no 2484 0.26746826445268 3525 766306
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.620499946773761 0.261486389881673 no 2485 0.267464344520367 3532 6312947
SGTC_2368 9071271 200 µM -0.6216684935989 0.261089376130811 no 2486 0.267079936380031 3517 27209959
SGTC_252 miconazole 1.30953 nM -0.621706657024939 0.26107641533482 no 2487 0.267067386747691 3504 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.621715609917729 0.261073374863847 no 2488 0.267064442728272 3482 390807
SGTC_2479 5617353 43.85 µM -0.622475982293937 0.260815213017984 no 2489 0.266814465920602 3588 2731746
SGTC_3209 9113616 49.47 µM -0.622699247758693 0.260739434813937 no 2490 0.266741088572082 3593 16649353
SGTC_1567 st069303 68.4 µM -0.624774542174811 0.260035604650658 no 2491 0.266059520719358 3572 5581319
SGTC_982 1491-0518 27.5 µM -0.625498102757081 0.259790441672853 no 2492 0.265822096612999 3504 3091256
SGTC_2435 5706476 10.6 µM -0.625723455949153 0.259714109944181 no 2493 0.265748172729987 3564 5725375
SGTC_452 diindolylmethane 8 µM -0.627070664026217 0.259258024618791 no 2494 0.265306457931562 3543 3071 Inhibits expression of several cancer promoting factors.
SGTC_1905 st060207 84.5 µM -0.627225104531899 0.259205766615763 no 2495 0.26525584469281 3497 1948547
SGTC_271 rotenone 740 µM -0.627729143776923 0.259035252845879 no 2496 0.265090695077605 3597 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1990 st072050 59.8 µM -0.62776304536622 0.259023786202613 no 2497 0.265079589018971 3551 17233948
SGTC_94 0334-0113 514.748 µM -0.628038894090781 0.258930494762562 no 2498 0.264989230593442 3512 6795178
SGTC_55 0767-0285 6.563 µM -0.630133414717866 0.258222699891842 no 2499 0.264303649596104 3540 3116166
SGTC_2598 perillyl alcohol 100 µM -0.630835577317778 0.257985644921625 no 2500 0.264074019185608 3579 10819 An apoptosis inducer.
SGTC_1556 plumbagin 1.48 µM -0.631099929805762 0.257896426944553 no 2501 0.263987593518356 3525 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2788 5282734 71.43 µM -0.631312865451057 0.25782457360245 no 2502 0.263917988219826 3597 743706
SGTC_1265 0819-1001 68.8 µM -0.632553353116275 0.257406188127247 no 2503 0.263512678481553 3578 3106768
SGTC_204 PMA1.184 62.41 µM -0.632726938563061 0.25734767024458 no 2504 0.263455987527596 3585 2252213 YGL008C PMA1
SGTC_2088 5278280 127.392 µM -0.63357243350539 0.25706274192128 no 2505 0.263179947916761 3597 791502
SGTC_3244 9134489 49.47 µM -0.634724202703876 0.256674864589613 no 2506 0.262804152886781 3538 16584271
SGTC_1716 st033144 30.6155 µM -0.63487788601067 0.256623132247113 no 2507 0.262754030421375 3600 674617
SGTC_348 k064-0012 10.7 µM -0.635157647585409 0.256528973815277 no 2508 0.262662801186422 3514 5066323
SGTC_3009 9080819 71.4286 µM -0.635185197032555 0.256519702562027 no 2509 0.262653818288246 3551 17027216
SGTC_2080 5212524 12.4 µM -0.636612635764239 0.256039563574679 no 2510 0.262188596283653 3560 260183
SGTC_825 1988-2224 89.6 µM -0.63775189630625 0.255656694011399 no 2511 0.261817598719053 3570 1180859
SGTC_2048 5246248 200 µM -0.639059234535687 0.255217707515319 no 2512 0.261392199079772 3579 677046
SGTC_2769 toremifene 3.73 µM -0.639673965100005 0.255011425623983 no 2513 0.261192292391704 3607 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2698 st077697 67.5 µM -0.640435150796013 0.254756119486344 no 2514 0.260944868289346 3519 3154499
SGTC_2024 5144227 134 µM -0.640772722678053 0.254642938750201 no 2515 0.260835178834707 3574 3475211
SGTC_1802 st050112 57.9 µM -0.64180235632032 0.254297887022719 no 2516 0.26050075976124 3574 4662563
SGTC_638 3970-0837 4.09 µM -0.642000877573061 0.254231386604134 no 2517 0.260436306599592 3560 4118451 YLR208W SEC13
SGTC_1939 st074455 53.6 µM -0.642952479064317 0.253912746899211 no 2518 0.260127467740557 3608 1644229
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.643371765787205 0.253772417075936 no 2519 0.259991449677519 3571 6708739 YPR165W RHO1
SGTC_2647 atorvastatin 60.16 µM -0.643787864653959 0.253633194453232 no 2520 0.259856502035572 3572 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_835 0312-0010 67.2 µM -0.644828240987871 0.253285270306453 no 2521 0.259519249237034 3564 1626196
SGTC_2270 7924575 90.91 µM -0.645435432944194 0.25308232832093 no 2522 0.259322523828101 3572 1262135
SGTC_2820 7989630 71.43 µM -0.646641440345682 0.25267949785169 no 2523 0.258932015570546 3491 2984098
SGTC_1786 berberine 21.6 µM -0.646740987039222 0.252646262368769 no 2524 0.258899795694858 3580 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_211 3455-0679 143.504 µM -0.646808752708248 0.252623638878987 no 2525 0.258877863441473 3609 748649
SGTC_3174 9107204 49.47 µM -0.646927639926684 0.252583951097783 no 2526 0.258839388100794 3625 3938802
SGTC_2475 5812728 15.03 µM -0.647393478169994 0.252428473300425 no 2527 0.258688657894802 3594 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2511 berberine 10.47 µM -0.647831120474295 0.252282452121999 no 2528 0.258547092390637 3595 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1426 4048-4480 71.7 µM -0.648775400763354 0.251967540845982 no 2529 0.258241779865416 3593 14224343
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.650114434611256 0.251521337743587 no 2530 0.257809152964046 3673 688664
SGTC_644 1498-1197 63.3 µM -0.650627526009207 0.251350472210367 no 2531 0.257643478592048 3624 6741615
SGTC_554 4483-2211 187 µM -0.651230366968884 0.25114979743219 no 2532 0.257448895238372 3558 747107
SGTC_1944 st076371 56.9 µM -0.654610328946572 0.250026240993961 no 2533 0.256359336089829 3559 24208455
SGTC_1737 st035557 69.7 µM -0.654770333258374 0.249973119052268 no 2534 0.256307816994862 3530 5716916
SGTC_1394 3474-0001 65.7 µM -0.654887493196318 0.249934225378132 no 2535 0.256270096596982 3527 5017666 YIL048W NEO1
SGTC_429 1112-0049 25.5 µM -0.656416798772814 0.249426835350853 no 2536 0.255777992347738 3564 2836170
SGTC_1662 st014054 52 µM -0.65832668050563 0.248793948076842 no 2537 0.255164118665589 3611 2838777
SGTC_2040 5100729 123 µM -0.658466898170012 0.248747517145467 no 2538 0.255119080319553 3615 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.659744023507925 0.2483248291407 no 2539 0.254709055199762 3564 4620898
SGTC_2642 cholecalciferol 100 µM -0.660241008127205 0.248160446540424 no 2540 0.254549590037649 3597 9821465 A vitamin D precursor, similar to steriods.
SGTC_2544 sphondin 68.51 µM -0.662460239130984 0.247427122588049 no 2541 0.253838154332793 3635 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_303 1348-1668 34.2 µM -0.664716619877515 0.246682711851526 no 2542 0.253115880804506 3623 5380509
SGTC_2643 anethole 100 µM -0.665067873177761 0.246566936586648 no 2543 0.253003541001842 3607 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2576 guaiol 23.12 µM -0.665627610975328 0.246382503705933 no 2544 0.25282457674454 3619 227829
SGTC_1202 1988-0068 29.6 µM -0.665682012257234 0.246364582497047 no 2545 0.252807186645551 3560 2850480
SGTC_3022 9087993 49.47 µM -0.665795694582231 0.246327134813632 no 2546 0.252770848599546 3633 17173644
SGTC_2572 astragaloside iv 100 µM -0.666177675858281 0.246201330097017 no 2547 0.252648770143206 3633 45006101 An anti-inflammatory agent.
SGTC_2250 alverine citrate 130 µM -0.66704255726151 0.24591661062182 no 2548 0.252372475093011 3574 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2301 7769476 200 µM -0.667778409595269 0.245674506786717 no 2549 0.252137525135969 3616 977820
SGTC_469 w7 172 µM -0.667970204367294 0.245611425147488 no 2550 0.252076306030257 3652 45115570 A P450 inhibitor.
SGTC_2010 4012422 159 µM -0.668610688173472 0.245400831941007 no 2551 0.251871926392257 3599 952393
SGTC_611 3453-1652 23.7 µM -0.669758182940907 0.245023774638145 no 2552 0.25150597741618 3625 1560575
SGTC_879 0831-1030 162 µM -0.670219611465194 0.244872240943442 no 2553 0.251358901915394 3648 1549252
SGTC_740 k014-0057 261 µM -0.671490016481986 0.244455299087195 no 2554 0.250954208663028 3630 4012779
SGTC_2949 9072542 2.23 µM -0.671580686360786 0.244425556225638 no 2555 0.250925338552924 3646 16457352
SGTC_1989 st071868 50.2 µM -0.671843501766687 0.244339354685806 no 2556 0.250841665681881 3621 16414057
SGTC_2849 9019321 12.99 µM -0.672236200270849 0.244210582972836 no 2557 0.25071666929461 3605 16489627
SGTC_182 3448-4371 550.524 µM -0.672960576620403 0.243973145161179 no 2558 0.250486186034417 3656 3491403
SGTC_3345 9148410 3.559 µM -0.673393984576805 0.24383114123811 no 2559 0.250348337282433 3597 4903596
SGTC_139 0099-0334 718.624 µM -0.675145243392002 0.243257804710007 no 2560 0.24979174567415 3677 97690
SGTC_2436 5633522 8.09 µM -0.675514910035796 0.243136874469429 no 2561 0.249674340879805 3628 5724242
SGTC_2919 7978188 46.38 µM -0.675843634434079 0.243029365109149 no 2562 0.249569963818772 3625 2980291
SGTC_359 0081-0058 15.9 µM -0.675957579494007 0.242992105363223 no 2563 0.249533789224635 3719 3494159
SGTC_2275 7947463 200 µM -0.677916232681475 0.242352114067218 no 2564 0.248912403539908 3598 1225414
SGTC_2409 alverine citrate 63.97 µM -0.677986754803475 0.242329087962037 no 2565 0.248890045660602 3717 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_767 0929-0023 86 µM -0.678389641392336 0.242197564613601 no 2566 0.248762337591085 3702 1204563
SGTC_2017 5132927 60.65 µM -0.679821693824077 0.241730380848394 no 2567 0.248308684346367 3626 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_555 4296-0685 37 µM -0.680066072887042 0.241650705046824 no 2568 0.248231312716072 3616 2908540 YHR072W ERG7
SGTC_2241 6772625 37.8075 µM -0.680149515792912 0.241623503115853 no 2569 0.248204897220363 3586 2285411
SGTC_2859 9028643 45.46 µM -0.68057277267918 0.241485549292369 no 2570 0.248070930004758 3613 17151580
SGTC_213 1246-0773 967 nM -0.680927669006415 0.241369909482197 no 2571 0.247958629681164 3613 6251622
SGTC_3303 9125618 40.5795 µM -0.68108922445209 0.241317278044434 no 2572 0.247907517460806 3663 22695467
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.681122876879163 0.241306315561419 no 2573 0.247896871357685 3653 5377381
SGTC_3120 9124077 49.47 µM -0.681772239227743 0.241094834821383 no 2574 0.247691490325107 3699 18774327 YGL155W CDC43
SGTC_1775 st081588 35.1725 µM -0.682166835636432 0.240966374082511 no 2575 0.247566731343269 3683 1426443 YGL099W LSG1
SGTC_556 4058-0063 51.5 µM -0.682944883304524 0.240713190007584 no 2576 0.247320835512273 3711 6615692
SGTC_3085 9117376 49.47 µM -0.683629181490812 0.240490632619714 no 2577 0.247104676427632 3688 16480349
SGTC_2076 5212012 200 µM -0.683759234330594 0.240448347623229 no 2578 0.247063606202518 3554 604802
SGTC_448 monastrol 171 µM -0.683984192941137 0.240375214805367 no 2579 0.246992573694088 3590 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.684531708984581 0.240197270968646 no 2580 0.246819736728836 3657 442882
SGTC_2775 cyproheptadine 69.59 µM -0.685329686669257 0.239938055199205 no 2581 0.24656795134951 3654 2913 A selective serotonin reuptake inhibitor.
SGTC_858 0438-0351 2.77 µM -0.686300875407724 0.239622779337994 no 2582 0.246261698529234 3666 2799119
SGTC_3200 9114385 49.47 µM -0.686433460930048 0.239579755804084 no 2583 0.246219905088359 3636 17018030 YLR208W SEC13
SGTC_880 0833-0487 87.2 µM -0.686581285955818 0.239531792077265 no 2584 0.246173312354861 3638 76075
SGTC_2534 helenine 20.12 µM -0.686687959799106 0.239497183636517 no 2585 0.246139692934075 3661 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2028 5153890 36.43 µM -0.688222755696313 0.238999548622998 no 2586 0.245656258032542 3640 2830968 YPR165W RHO1
SGTC_1622 st003707 19.4 µM -0.688682887111041 0.238850467995634 no 2587 0.24551142378743 3689 10140899
SGTC_2248 tofa 1.1 µM -0.689561060548648 0.238566084745612 no 2588 0.24523513103141 3610 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1068 loratadine 26.9 µM -0.691518447499032 0.237932881901261 no 2589 0.244619895925065 3667 3957 A H1 histamine antagonist.
SGTC_502 l-744,832 89.3 µM -0.692027557822875 0.237768338919793 no 2590 0.244460011492645 3628 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_862 0452-0056 10.2 µM -0.69254317454069 0.237601756727001 no 2591 0.244298141153121 3614 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2702 st077768 96.8 µM -0.693320461010182 0.237350757012366 no 2592 0.244054232649285 3599 6484119
SGTC_1617 st002906 78 µM -0.693377247548042 0.237332425331622 no 2593 0.244036418475188 3677 5150859
SGTC_627 1391-0720 175 µM -0.694572801738735 0.236946660223952 no 2594 0.243661531011811 3640 997839
SGTC_1462 k081-0014 26.5 µM -0.696383233290579 0.236363151619179 no 2595 0.243094430202494 3469 3270634
SGTC_2407 paclitaxel 400 µM -0.697107329747563 0.236129994390767 no 2596 0.24286781372248 3788 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2763 lisinopril 49.32 µM -0.69834254309593 0.235732551388558 no 2597 0.242481499774131 3637 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2464 5717415 7.67 µM -0.699178718669245 0.235463712547826 no 2598 0.242220174249967 3633 5285744
SGTC_364 0083-0097 67.7 µM -0.699746546101357 0.235281246827454 no 2599 0.242042801220014 3703 5207356
SGTC_2877 9040724 71.43 µM -0.700246778461867 0.235120566812824 no 2600 0.241886601333734 3665 6463895
SGTC_1334 1486-0610 236 µM -0.703950617051209 0.233932741707598 no 2601 0.24073176385305 3704 3742339
SGTC_786 4544-0069 423 µM -0.704824844580686 0.233652861735394 no 2602 0.240459622643029 3714 748821 YLR208W SEC13
SGTC_3293 9120939 62.045 µM -0.704856523043337 0.233642723506185 no 2603 0.240449764495137 3675 934087
SGTC_2261 9010538 184.68 µM -0.705097843064632 0.233565500564943 no 2604 0.240374674375071 3614 6457250
SGTC_111 0083-0039 52.457 µM -0.706343973419866 0.233166961429963 no 2605 0.239987126749091 3603 759313
SGTC_2236 dapsone 200 µM -0.70634747934529 0.233165840692838 no 2606 0.239986036884087 3703 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2022 5136654 200 µM -0.706919698960654 0.232982959664095 no 2607 0.239808190742047 3686 1713771
SGTC_1466 k213-0079 57.5 µM -0.707068943914435 0.232935274172853 no 2608 0.239761817161039 3652 3657981
SGTC_2367 9070478 135.38 µM -0.707425790849711 0.232821279424731 no 2609 0.239650957068147 3666 572802
SGTC_1903 st060211 78.3 µM -0.70802193495842 0.232630910361322 no 2610 0.239465817982425 3716 688960
SGTC_2426 5582046 32.21 µM -0.708931583861259 0.232340595390513 no 2611 0.239183467118942 3681 2251934
SGTC_468 gf-109203x 121 µM -0.712480703677942 0.231209821223085 no 2612 0.238083578158739 3634 2396 A protein kinase C inhibitor.
SGTC_1975 st070967 30.8 µM -0.712811095474629 0.231104712553385 no 2613 0.237981329406851 3687 261391
SGTC_935 2996-0153 430 µM -0.715703448567672 0.230185697796115 no 2614 0.237087240481239 3686 23738523
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.716802139000365 0.229837136969769 no 2615 0.236748095854542 3695 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1720 st037298 9.481 µM -0.717389229593615 0.229651003001474 no 2616 0.236566981705506 3719 597396
SGTC_2894 9048625 32.47 µM -0.719027702438027 0.229131980758272 no 2617 0.236061925557702 3739 4092861
SGTC_559 1550-0661 158 µM -0.720237783158372 0.22874908388541 no 2618 0.23568930220078 3738 5830875
SGTC_677 0929-0063 136 µM -0.720475424480731 0.228673931025896 no 2619 0.235616162806184 3671 1539583
SGTC_2889 9059656 51.95 µM -0.720660410627617 0.228615439695892 no 2620 0.235559237878318 3783 3949838
SGTC_1324 1418-0026 34.4 µM -0.720909874919776 0.228536574133387 no 2621 0.235482483407084 3756 1372513
SGTC_1956 st077085 54 µM -0.721279378722073 0.228419787405298 no 2622 0.235368820880565 3741 24208685
SGTC_421 streptovitacin 30 mM -0.723905016594458 0.227590885085445 no 2623 0.234562024974337 3780 91467 include heat shock
SGTC_2802 7925815 54.55 µM -0.725282690382372 0.227156637917447 no 2624 0.234139311325007 3729 1262923
SGTC_488 nitrendipine 139 µM -0.726044357036198 0.226916758783919 no 2625 0.233905789234577 3742 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_742 0kpi-0133 140 µM -0.726433729951136 0.226794184970948 no 2626 0.233786459871807 3728 2728852
SGTC_2835 9006588 71.43 µM -0.726921401636742 0.226640719607406 no 2627 0.233637052931845 3731 2345538
SGTC_1423 4048-0112 5.59 µM -0.727608938762985 0.226424458203399 no 2628 0.233426503601623 3727 X1423
SGTC_2833 9001315 45.46 µM -0.727654897864226 0.226410006151749 no 2629 0.233412432977057 3717 2989378
SGTC_3229 9132204 49.47 µM -0.728455235130528 0.226158419939512 no 2630 0.233167480900375 3716 17682924
SGTC_1054 3429-0080 167 µM -0.728819845564825 0.226043856961356 no 2631 0.233055935173659 3730 1162877
SGTC_2402 5553605 200 µM -0.729409053573769 0.225858793314767 no 2632 0.232875740678331 3754 6758546
SGTC_838 0109-0203 71.4 µM -0.72971087241485 0.225764028588506 no 2633 0.23278346694067 3734 759422
SGTC_264 promethazine 12.5 mM -0.731331730626718 0.225255498305385 no 2634 0.232288276816467 3746 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2662 daunorubicin 22.37 µM -0.732797027779368 0.224796332832721 no 2635 0.231841117191776 3624 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1634 st006576 41 µM -0.734082523803251 0.22439394722969 no 2636 0.231449222007779 3703 3915356
SGTC_316 k060-0003 58.6 µM -0.735564504520839 0.223930565771519 no 2637 0.23099788539951 3715 6152314
SGTC_2768 sulfasalazine 50.2 µM -0.737110370434085 0.223447788805371 no 2638 0.23052761657216 3740 5384001 An antioxidant and salicylic acid derivative.
SGTC_1993 st073995 70.8 µM -0.737344398217461 0.223374753110635 no 2639 0.230456469498229 3746 3098394
SGTC_3266 9136860 49.47 µM -0.738499408955702 0.223014494876283 no 2640 0.230105513100178 3673 4871271 YPR165W RHO1
SGTC_2495 cafestol 54.53 µM -0.739606987227565 0.22266934226843 no 2641 0.229769250365588 3726 16667697 An anti-infammatory.
SGTC_132 0417-1715 25.805 µM -0.739807027290314 0.222607036625479 no 2642 0.22970854719697 3740 6769098
SGTC_1979 st071809 45.3 µM -0.739928782582406 0.222569118879318 no 2643 0.229671604335441 3831 4976333
SGTC_1898 st060199 18.6 µM -0.743121413810072 0.22157616607849 no 2644 0.228704088074401 3745 688866
SGTC_29 0299-0004 12.984 µM -0.74334267492804 0.221507444728779 no 2645 0.228637120531793 3641 16871 A napthoquinone isolated from Swertia calycina.
SGTC_599 1935-0052 86.5 µM -0.74339675994709 0.221490648350434 no 2646 0.228620752675431 3739 9557311
SGTC_2168 5727979 200 µM -0.743431646285493 0.221479814606513 no 2647 0.228610195302933 3683 695210
SGTC_1227 3909-8010 46.6 µM -0.743778142857757 0.221372228614238 no 2648 0.228505352693159 3737 15982272
SGTC_1658 st012944 20 µM -0.743848747377557 0.221350309819701 no 2649 0.228483992556576 3678 24207260
SGTC_2067 5224629 34.075 µM -0.744627991058673 0.221108480248151 no 2650 0.228248320819991 3726 2835000
SGTC_571 k831-0106 44.2 µM -0.745626017012048 0.220798974955825 no 2651 0.22794668101597 3701 4783639
SGTC_3144 9087057 49.47 µM -0.745887154825275 0.220718032523419 no 2652 0.227867792685762 3653 17249618
SGTC_2705 st078069 42.8 µM -0.747531715322783 0.220208674255848 no 2653 0.227371332952278 3768 1530061
SGTC_1213 1315-0166 115 µM -0.747764352014297 0.220136675774367 no 2654 0.227301153845153 3801 768401
SGTC_100 0086-0128 49.5915 µM -0.753229051423045 0.218449299650351 no 2655 0.225656142319214 3762 93297
SGTC_1632 st005650 90 µM -0.753435149092758 0.218385807431258 no 2656 0.225594233848179 3791 2759605
SGTC_1496 4469-0713 57.4 µM -0.754320895227338 0.218113057901112 no 2657 0.225328279200642 3725 746691
SGTC_730 1436-0052 41.2 µM -0.75484477467157 0.217951831133482 no 2658 0.225171062451023 3779 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2644 guaiazulene 100 µM -0.755054831522309 0.21788720429309 no 2659 0.225108041635604 3785 3515 A coloring agent.
SGTC_3287 9117173 37.0625 µM -0.756186219393013 0.217539307577589 no 2660 0.224768776939588 3756 2789709
SGTC_2841 9004761 38.96 µM -0.757359134232361 0.217178980214903 no 2661 0.224417366021541 3740 2991039
SGTC_479 n-linoleoylglycine 10 µM -0.758306553678761 0.216888178452307 no 2662 0.224133742407206 3799 6433346 An anti-infammatory.
SGTC_1203 3992-3522 103 µM -0.759951317315631 0.216383868204668 no 2663 0.223641842617759 3868 5322312
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.760395455398483 0.216247804993725 no 2664 0.223509119493456 3716 140250 A respiratory chain inhibitor.
SGTC_691 1548-0686 185 µM -0.761343148791124 0.215957641577074 no 2665 0.22322606726653 3788 46495133
SGTC_3181 9108277 49.47 µM -0.762117423990015 0.215720742622455 no 2666 0.22299496223105 3733 17097298
SGTC_244 nsc-207895 1.295 µM -0.762439264589196 0.21562231590128 no 2667 0.222898939617909 3634 42640
SGTC_2403 6032726 181.2 µM -0.763100303848031 0.215420235629575 no 2668 0.222701789429004 3826 2881040
SGTC_3057 9095946 49.47 µM -0.763404124369901 0.215327394299017 no 2669 0.222611210498352 3784 24540043
SGTC_908 3448-7491 47.7 µM -0.763513726403183 0.215293907861166 no 2670 0.222578539668465 3811 1203031
SGTC_646 4092-0839 27.3 µM -0.763572576420888 0.215275928807979 no 2671 0.222560998431109 3804 877796
SGTC_821 1114-0266 29.2 µM -0.764224962543111 0.215076679089885 no 2672 0.222366596584104 3795 3123235
SGTC_2440 5628896 157.78 µM -0.764326193319855 0.215045771103411 no 2673 0.222336439926473 3805 5522048
SGTC_2284 7945075 39.21 µM -0.765782669975861 0.214601362262081 no 2674 0.22190281374182 3853 1245402
SGTC_181 1447-1644 8.07 µM -0.766607874575858 0.2143498080042 no 2675 0.221657346080436 3746 534600
SGTC_1277 0873-0036 22 µM -0.766731662479725 0.214312087464684 no 2676 0.221620537173656 3825 5965735
SGTC_489 paxilline 115 µM -0.772251980990119 0.212633869982624 no 2677 0.219982599921971 3734 105008 A toxic potassium channel blocker.
SGTC_2352 9027995 87.8 µM -0.772805909824634 0.212465896263687 no 2678 0.219818627673505 3760 2997347
SGTC_27 0485-0001 32.618 µM -0.773382040995406 0.212291272165859 no 2679 0.219648157614273 3725 2054479
SGTC_1245 0418-0076 17.2 µM -0.773540447326787 0.212243274259441 no 2680 0.219601300456967 3825 6790114
SGTC_33 0986-0033 35.816 µM -0.775172322076855 0.211749177480836 no 2681 0.21911892039994 3709 2848082
SGTC_95 0471-0001 561.058 µM -0.776890767398779 0.211229597328039 no 2682 0.218611609405351 3731 4015405
SGTC_1174 0739-0097 51.1 µM -0.781465931732629 0.209849921688479 no 2683 0.217264253218819 3813 728447
SGTC_2189 6047310 154.431 µM -0.782323217437663 0.209591991189193 no 2684 0.217012322749723 3754 711535
SGTC_398 bronopol 33.3 µM -0.782480031061723 0.209544831047836 no 2685 0.216966258216576 3725 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1221 2958-7315 257 µM -0.783357963605983 0.20928091686766 no 2686 0.216708466969384 3818 4562705
SGTC_278 4092-0821 23.9 µM -0.784277929428052 0.20900457714479 no 2687 0.216438523467186 3814 877900
SGTC_261 5-fluorouridine 15.376 µM -0.785311265316658 0.208694439681641 no 2688 0.216135546209873 3823 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1383 3049-0032 20.7 µM -0.788251425080115 0.207813487982685 no 2689 0.215274827209273 3861 712864
SGTC_1315 1237-0019 3.69 µM -0.789365032540365 0.207480395259969 no 2690 0.214949343560848 3812 825140
SGTC_318 1488-0629 67.2 µM -0.789729277831461 0.207371513855509 no 2691 0.214842944513125 3876 3662576
SGTC_2722 naftopidil 47.16 µM -0.790967083182747 0.207001757534859 no 2692 0.2144816001088 3747 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1843 st055809 45.5 µM -0.791784548645516 0.206757778879382 no 2693 0.214243156636246 3865 16413835
SGTC_2537 larixol 68.93 µM -0.792610835014648 0.206511340657822 no 2694 0.214002297016757 3813 6708759
SGTC_1571 st070080 73.4 µM -0.79274123858108 0.206472463964202 no 2695 0.213964299233756 3888 4315245
SGTC_3301 9125354 19.7965 µM -0.793789013996719 0.206160252282963 no 2696 0.213659134661148 3795 41905162
SGTC_779 1360-0071 233 µM -0.794161500986223 0.206049327660613 no 2697 0.213550708953143 3905 7566
SGTC_1270 0831-1170 17.3 µM -0.79435371421713 0.205992101440982 no 2698 0.213494770936837 3821 6764716
SGTC_2362 9071156 126 µM -0.795044374005897 0.205786554226133 no 2699 0.21329384516803 3831 653133
SGTC_2065 5221596 34.26 µM -0.795400654332221 0.20568056926216 no 2700 0.213190239722051 3819 788581
SGTC_2770 toltrazuril 17.5 µM -0.796056147289096 0.205485660278142 no 2701 0.212999700669317 3770 68591 Kills coccidiodes.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.798123946498584 0.204871525107557 no 2702 0.212399283156895 3830 688761
SGTC_37 0566-0070 1.56 µM -0.798559381938617 0.204742340284439 no 2703 0.212272973902537 3839 1626686
SGTC_362 0310-0100 9.03 µM -0.799502455187677 0.204462715828032 no 2704 0.21199956179586 3905 790235
SGTC_2855 9016525 58.44 µM -0.79990401551853 0.204343720840634 no 2705 0.211883205544433 3804 43811474
SGTC_2731 amoxapine 43.43 µM -0.801549439151611 0.203856560707476 no 2706 0.211406817406334 3881 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3074 9116018 49.47 µM -0.80317599744428 0.203375667028634 no 2707 0.210936508349529 3878 17027303
SGTC_737 1950-0117 57.9 µM -0.804234706077994 0.20306302268134 no 2708 0.2106307193016 3772 5393513
SGTC_1762 st045503 25.4615 µM -0.804461376092763 0.202996122696748 no 2709 0.21056528354403 3914 4645554
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.804492449803562 0.202986952545947 no 2710 0.21055631402491 3872 94937 An inhibitor of serotonin biosynthesis.
SGTC_1834 st055981 52.8 µM -0.804627775194499 0.202947019606787 no 2711 0.210517254562555 3898 471719 YDL150W RPC53
SGTC_2370 9071495 200 µM -0.804943436771082 0.202853889808145 no 2712 0.210426160538083 3852 21791103
SGTC_1263 0774-1208 64.8 µM -0.806522359061284 0.202388442891515 no 2713 0.209970860567631 3833 906585
SGTC_668 1682-0499 62.6 µM -0.808091763449899 0.201926435201651 no 2714 0.20951887938775 3862 682214
SGTC_601 0986-0029 62.9 µM -0.809483297153946 0.201517318358048 no 2715 0.209118603268793 3813 24747981
SGTC_1163 k060-0048 49.9 µM -0.81128631711322 0.200987962117408 no 2716 0.208600632947582 3847 6809982
SGTC_823 0417-1665 178 µM -0.8130347383636 0.20047543325491 no 2717 0.208099070771906 3879 3429856
SGTC_1907 st060210 83.7 µM -0.813237035487222 0.200416182970355 no 2718 0.208041084632478 3887 688793
SGTC_1112 tnp00069 1.16933 µM -0.814075593759997 0.200170691984657 no 2719 0.207800823295971 3878 145826
SGTC_1833 st055984 71 µM -0.814847057032449 0.199945002994703 no 2720 0.207579930632373 3882 676288
SGTC_1672 st016598 6.51 µM -0.818424726683986 0.198900369480573 no 2721 0.206557353693092 3892 4665860 YNL267W PIK1
SGTC_1002 4049-0206 172 µM -0.819314757216039 0.198641003887542 no 2722 0.206303427563436 3877 4662749
SGTC_797 k781-0471 270 µM -0.81962636778366 0.198550245051905 no 2723 0.206214568665822 3838 23738129
SGTC_2457 5731572 11.68 µM -0.820834195120076 0.198198693032001 no 2724 0.205870358979667 3938 2865357
SGTC_1344 1488-0097 29.1 µM -0.82093821825786 0.198168433487602 no 2725 0.205840730153703 3895 747966
SGTC_3034 9090421 49.47 µM -0.822388303616767 0.197746905110769 no 2726 0.205427967027946 3764 17173761
SGTC_2602 kawain 100 µM -0.823946241467147 0.197294629154515 no 2727 0.204985052155574 3813 5369129
SGTC_3165 9101544 49.47 µM -0.824332905970355 0.19718247580585 no 2728 0.20487521313478 3878 5002184
SGTC_1742 st038235 28.8875 µM -0.825211495794189 0.196927781296107 no 2729 0.204625764002927 3909 564103 YBR002C RER2
SGTC_3010 9080089 71.4286 µM -0.825720963407407 0.196780182938635 no 2730 0.20448119881981 3871 17027233
SGTC_2374 9071832 200 µM -0.826063950371432 0.196680853594987 no 2731 0.204383907990724 3791 17381698
SGTC_2445 5742597 35.57 µM -0.828362862575118 0.196015870777288 no 2732 0.203732515918458 3825 1774255
SGTC_837 0091-0265 12.5 µM -0.828541966679495 0.19596412049538 no 2733 0.203681819159119 3843 759367
SGTC_1930 st074634 34.3 µM -0.830659962533157 0.195352776236527 no 2734 0.203082875163802 3804 684253 YOR116C RPO31
SGTC_1604 st002052 72.4 µM -0.83190915484004 0.194992749686697 no 2735 0.202730112000981 3928 6254834 YHR062C RPP1
SGTC_1600 coumarin 106 71.1 µM -0.832315232088165 0.194875802129799 no 2736 0.202615517534083 3965 100336 A hepatotoxic, DNA x-linker.
SGTC_2767 sibutramine 71.45 µM -0.835196154350781 0.194047340985559 no 2737 0.201803637299177 3861 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2320 7373003 200 µM -0.837320844034323 0.193437725161904 no 2738 0.201206122942801 3963 5415828
SGTC_3132 9126706 49.47 µM -0.837422036933198 0.193408720080555 no 2739 0.201177691530889 3942 850858
SGTC_3321 9137793 26.8275 µM -0.837749185765034 0.193314967048839 no 2740 0.201085791455668 3853 4904192
SGTC_1481 3346-2004 36 µM -0.839277620187508 0.192877321861218 no 2741 0.200656769407632 3915 2770522
SGTC_3169 9102970 49.47 µM -0.839980495196111 0.192676267033413 no 2742 0.200459661356296 3960 17027839
SGTC_696 1560-0013 611 µM -0.840151550079273 0.192627356792804 no 2743 0.200411709838027 3924 1650269
SGTC_3026 9090633 49.47 µM -0.840727222535532 0.1924628087718 no 2744 0.200250383198228 3895 25236842
SGTC_517 1365-0151 113 µM -0.842250122131913 0.192027923505899 no 2745 0.199823981749008 3971 768657
SGTC_1525 8-methoxypsoralen 92.5 µM -0.842389794723554 0.191988068173037 no 2746 0.199784901739793 3909 4114 Related to psoralen; DNA damaging agent.
SGTC_234 nsc-17383 10.7 µM -0.842539861753903 0.191945252447222 no 2747 0.19974291851888 3880 408974
SGTC_2715 st079500 56.4 µM -0.843189150699107 0.191760070734916 no 2748 0.199561332584841 3836 28246688
SGTC_3117 9124945 49.47 µM -0.843493074500321 0.19167342715858 no 2749 0.199476368692889 3807 17592065
SGTC_1239 0337-0584 35.4 µM -0.845792880919475 0.191018568367549 no 2750 0.198834148800515 3974 914301 YML130C ERO1
SGTC_612 0302-0167 22.4 µM -0.847160030247258 0.190629930305549 no 2751 0.198452964373607 3913 235821
SGTC_1950 st077106 7.18 µM -0.848105859393875 0.190361344732565 no 2752 0.198189509367561 3911 13831864
SGTC_1612 st002233 45.4 µM -0.848762176296634 0.190175108149395 no 2753 0.198006820399962 3891 1035021
SGTC_253 dyclonine 31.25 µM -0.849811571150692 0.189877564407131 no 2754 0.197714927689564 3985 3180 An oral anasthetic.
SGTC_2792 7535235 81.82 µM -0.850283130367941 0.189743952517922 no 2755 0.197583846630612 3908 1281891
SGTC_3008 9078912 71.4286 µM -0.851458700876294 0.18941111745767 no 2756 0.197257297752377 3888 16648731
SGTC_148 3253-0744 288.01 µM -0.852395712406532 0.189146082259695 no 2757 0.196997249535928 3835 6893655
SGTC_2390 9097792 176.6 µM -0.854257543167268 0.188620138608662 no 2758 0.196481153005079 3920 4497149
SGTC_1039 k821-0043 94 µM -0.854328470535822 0.188600120367986 no 2759 0.196461508265996 3899 15992768
SGTC_367 0335-0881 7.1 µM -0.856156298835655 0.188084693745822 no 2760 0.195955665702848 3910 23828853
SGTC_1546 5-methoxyflavanone 78.7 µM -0.85882691454177 0.187333175656342 no 2761 0.195218008083366 3901 147795
SGTC_1958 st076513 41.9 µM -0.859216610721173 0.187223669568453 no 2762 0.195110510358946 3896 732122 YGL099W LSG1
SGTC_3292 9120825 59.784 µM -0.860678815839712 0.186813137456206 no 2763 0.194707481834693 3884 24824900
SGTC_2622 2-methoxyxanthone 59.94 µM -0.862132910292847 0.186405435485115 no 2764 0.194307191536053 3931 71034 A hepatoprotective.
SGTC_3228 9131799 49.47 µM -0.862507818536015 0.186300407386967 no 2765 0.194204066254899 3926 17015818
SGTC_2710 st078562 53.7235 µM -0.862550094732199 0.186288566287273 no 2766 0.194192439515617 3886 17250908
SGTC_97 0535-0701 19.132 µM -0.862825511463727 0.186211436491301 no 2767 0.194116705176311 3841 2832013 YGL099W LSG1
SGTC_642 0335-0876 158 µM -0.862892098796439 0.186192791839387 no 2768 0.194098397633179 3941 6812350
SGTC_2273 7815444 169.05 µM -0.868289997334686 0.184685214197295 no 2769 0.192617798316714 3846 2824616
SGTC_933 2914-0560 114 µM -0.868819294094572 0.184537796725439 no 2770 0.192472989099174 3986 463887
SGTC_128 0906-2981 13.371 µM -0.869645697931379 0.184307776637588 no 2771 0.192247028090958 3847 6740226
SGTC_918 glabranin 770.725 nM -0.869742201730166 0.184280927542959 no 2772 0.192220651944545 3957 124049 Also referred to as licorice root.
SGTC_3343 9148379 18.9835 µM -0.869832642168263 0.184255767593853 no 2773 0.192195935028274 3984 1955036
SGTC_1214 0358-0031 63.7 µM -0.870230799441368 0.184145028220059 no 2774 0.192087143773381 4091 4301366
SGTC_2718 lomofungin 53.02 µM -0.870394061472804 0.184099632174495 no 2775 0.192042545458823 3889 5351222 A RNA synthesis inhibitor.
SGTC_3021 9087658 49.47 µM -0.871008269528053 0.183928910133654 no 2776 0.191874818916973 3876 25237042
SGTC_1645 Cervolide 78 µM -0.872143351765429 0.183613668197123 no 2777 0.191565089322736 3918 23173 A fragrance.
SGTC_1873 rapamycin 2 nM -0.872155395648754 0.183610325102874 no 2778 0.191561804554409 3906 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.873410389539063 0.183262176705307 no 2779 0.191219715038365 3917 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_687 k029-0044 34.9 µM -0.876652342083165 0.182364732161021 no 2780 0.190337749941114 4014 5829338
SGTC_1209 2323-2347 50.3 µM -0.879516334858536 0.181574203797853 no 2781 0.189560690116843 3923 5412760
SGTC_3316 9136639 10.545 µM -0.880037878401225 0.181430476871979 no 2782 0.189419395053508 3960 4903665
SGTC_1364 1653-0028 37.6 µM -0.880259909605024 0.181369311151982 no 2783 0.189359262679942 3945 5718652
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.881102901462066 0.181137199200123 no 2784 0.18913106348956 3976 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1883 5-benzylidenerhodanine 20 µM -0.881463373580075 0.181038002528842 no 2785 0.189033534848188 3945 1273210
SGTC_358 0075-0058 9.45 µM -0.881781782742555 0.180950409285961 no 2786 0.188947412450713 3815 1069125
SGTC_144 4161-2749 112.381 µM -0.881798687146898 0.18094575968622 no 2787 0.188942840871721 3854 797501 YMR168C CEP3
SGTC_1302 1159-0335 255 µM -0.881906611287509 0.180916076639636 no 2788 0.188913655780689 3951 649284
SGTC_245 methotrexate 289.6 µM -0.884799011942052 0.180121698828514 no 2789 0.18813252123554 3937 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2448 5185112 27.17 µM -0.885232880142781 0.180002729070978 no 2790 0.188015521034189 3984 5718189
SGTC_1188 1403-0014 4.57 µM -0.886308021280129 0.179708130385033 no 2791 0.187725783912994 3960 9614867
SGTC_794 k038-0031 316 µM -0.887164394650379 0.179473692980133 no 2792 0.18749519941746 3942 6624242
SGTC_1139 k015-0024 46.9 µM -0.889227397007743 0.178909723417607 no 2793 0.186940440791796 3953 2766652
SGTC_2338 7999974 200 µM -0.890430504702608 0.178581341473004 no 2794 0.186617384396238 3982 315925
SGTC_1082 camptothecin 424.86 nM -0.892939137887337 0.1778978450375 no 2795 0.185944883234684 3874 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_541 4513-1321 94 µM -0.894145497406778 0.177569751341318 no 2796 0.185622024472211 3962 747515
SGTC_389 tpck 16.7 µM -0.896452881023011 0.17694327656619 no 2797 0.185005467561084 3975 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1380 2291-0730 164 µM -0.897203241977751 0.176739848351706 no 2798 0.184805237794513 4006 2999191
SGTC_147 4466-0538 29.23 µM -0.898092616416112 0.176498924154737 no 2799 0.184568087547161 4033 6742687 YHR072W ERG7
SGTC_2044 5102272 200 µM -0.89822781750065 0.176462317494515 no 2800 0.184532052976843 3990 592666
SGTC_2759 disulfiram 3.38 µM -0.898275819284131 0.176449321823811 no 2801 0.184519260318131 3884 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_744 1594-0068 283 µM -0.898388132194048 0.176418917369304 no 2802 0.184489330653649 3966 668392
SGTC_2986 9022445 71.43 µM -0.898521271372953 0.176382879286971 no 2803 0.184453855020166 3979 6459286
SGTC_2786 7743617 45.45 µM -0.902670360851183 0.175262139534109 no 2804 0.183350435705246 3924 583674
SGTC_1168 k815-0004 80.5 µM -0.902738121589873 0.175243873761393 no 2805 0.183332449466614 3953 642433
SGTC_2808 7946468 45.46 µM -0.904164033225459 0.174859781087687 no 2806 0.182954214291323 3997 2970879
SGTC_2478 5763493 32.33 µM -0.904401614688622 0.174795836591396 no 2807 0.182891241149138 3908 1365576 YLR208W SEC13
SGTC_1870 st057514 26.5 µM -0.906399843905299 0.174258605398785 no 2808 0.182362127698038 3955 5393161
SGTC_771 0250-0039 27.3 µM -0.907919084562536 0.173850854910659 no 2809 0.181960486870904 3935 3005115
SGTC_2944 9067346 25.62 µM -0.908926660803395 0.173580765477669 no 2810 0.18169441981527 3942 6473075
SGTC_2218 6965428 192.983 µM -0.909502215922309 0.173426602892199 no 2811 0.181542544328948 3874 675684
SGTC_503 tyrphostin 8 294 µM -0.910196473067457 0.173240761944054 no 2812 0.181359451924722 3978 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2289 7946404 165.07 µM -0.910434584685428 0.173177052688703 no 2813 0.181296682767102 4021 1246120 YPR165W RHO1
SGTC_2563 tomatine 8.54 µM -0.915548948073997 0.171812254536719 no 2814 0.179951759131957 3870 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1349 flufenamic acid 69 µM -0.915583901702776 0.171802950650694 no 2815 0.179942588989524 3917 3371 A non-steroidal anti-inflammatory.
SGTC_427 1354-0053 47.3 µM -0.915755133917621 0.171757377056224 no 2816 0.179897670174469 4101 6813657
SGTC_2107 5363541 170.161 µM -0.916271333886137 0.171620036741188 no 2817 0.17976229966023 3969 244052
SGTC_2744 captopril 92.04 µM -0.919480060857821 0.170767896109646 no 2818 0.178922265080993 4002 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2307 7538926 6.34 µM -0.922268473463177 0.170029581230649 no 2819 0.178194277154306 4008 96582
SGTC_580 1123-0028 41 µM -0.922710873100875 0.169912631151697 no 2820 0.178078949009495 4056 1677248 YPR107C YTH1
SGTC_971 1315-0384 26.7 µM -0.922723342638382 0.169909335528029 no 2821 0.178075699036436 4021 6769120
SGTC_946 3434-1334 87.4 µM -0.92288815677847 0.169865779993952 no 2822 0.178032746544935 3990 4047976
SGTC_940 3232-1287 54.8 µM -0.923563557430683 0.169687366235856 no 2823 0.177856797480595 3887 1585493 YIL048W NEO1
SGTC_2932 9016711 44.54 µM -0.923650429453786 0.169664426859576 no 2824 0.177834174356698 4025 7117328
SGTC_1103 duloxetine 36.1 µM -0.923922878922257 0.16959249691264 no 2825 0.177763235116755 4084 60835 A selective serotonin reuptake inhibitor.
SGTC_616 4092-0450 108 µM -0.925110792589714 0.169279102020961 no 2826 0.177454139831696 4023 787165
SGTC_1130 3454-2858 15.9 µM -0.925633042231907 0.169141440061162 no 2827 0.177318357841305 4050 715628 YIL048W NEO1
SGTC_3047 9092122 49.47 µM -0.926387211337234 0.1689427723788 no 2828 0.177122393892735 3981 17173831
SGTC_3051 9093778 49.47 µM -0.927605325989631 0.168622206137367 no 2829 0.176806166993154 4030 17217378
SGTC_2056 5235370 200 µM -0.930297551869315 0.167915092119764 no 2830 0.176108522512852 3967 5511916
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.93048822382405 0.167865084551445 no 2831 0.176059179289386 4000 5106787 A p450 inhibitor.
SGTC_2585 alliin 100 µM -0.931451047911084 0.167612710967033 no 2832 0.175810147650179 4072 87310 A garlic compound which reacts with lipids.
SGTC_848 0368-0089 85.6 µM -0.93411651573378 0.166915319225027 no 2833 0.175121896716279 4025 762535
SGTC_341 1486-1430 230 µM -0.934169604141716 0.166901448235658 no 2834 0.17510820613037 3990 2054753 YPL210C SRP72
SGTC_1387 3342-1166 1.8 µM -0.934272912617555 0.166874457830816 no 2835 0.17508156660017 3995 3418228
SGTC_1703 st026983 48.3 µM -0.93872229142352 0.165714684081799 no 2836 0.173936672689436 4027 1104023
SGTC_2124 5246320 200 µM -0.940531716428084 0.165244534135847 no 2837 0.173472444418572 4035 579342
SGTC_557 1315-0110 16.2 µM -0.947792617925189 0.163366597679944 no 2838 0.171617519678877 4018 6833801
SGTC_171 k064-0041 9.68 µM -0.950511570060329 0.162666958402055 no 2839 0.170926188884108 4041 53325
SGTC_2131 toluylene red 5.2905 µM -0.951062738783918 0.162525369921279 no 2840 0.170786264196143 4027 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1763 st044482 94.5 µM -0.951155140522514 0.16250164089989 no 2841 0.170762813430282 4034 88505
SGTC_1849 st056239 19.2 µM -0.953925647323656 0.16179121434606 no 2842 0.170060640032243 4042 5393181
SGTC_3161 9100388 49.47 µM -0.954216875722001 0.161716653904186 no 2843 0.169986937046256 4093 25236368
SGTC_3035 9091303 49.47 µM -0.955238072521484 0.161455383549835 no 2844 0.169728658215859 4093 25237002
SGTC_270 tamoxifen 5.46 µM -0.955962772731419 0.161270138089025 no 2845 0.169545521409948 4055 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_832 4083-0019 164 µM -0.957325654673593 0.160922138421575 no 2846 0.169201455170212 4101 1990758
SGTC_2988 9073640 71.4286 µM -0.958656928931563 0.1605826831085 no 2847 0.168865801577397 4115 9102229
SGTC_1172 0370-0043 85 µM -0.959648227229837 0.160330220686103 no 2848 0.168616144040617 4067 376585
SGTC_3079 9117512 49.47 µM -0.962010906075502 0.159729543497264 no 2849 0.168022062799704 4084 7185044
SGTC_2147 5545932 89.7195 µM -0.963059368042773 0.159463459386692 no 2850 0.167758865459285 4069 797404
SGTC_2925 9010536 32.5 µM -0.964236863850366 0.159164974534664 no 2851 0.167463593188516 4009 2994177
SGTC_1207 2099-0101 141 µM -0.965975096966852 0.158725017006996 no 2852 0.167028321195301 4060 5837381
SGTC_2153 5569715 200 µM -0.966543448681765 0.158581336806166 no 2853 0.166886158318752 4065 2054701
SGTC_768 0384-0033 77.3 µM -0.971647760391119 0.157294782645218 no 2854 0.165612906810785 4030 3965305 YMR134W ERG29
SGTC_2774 tamoxifen 10.92 µM -0.973330719133604 0.156872097265582 no 2855 0.165194479795275 4055 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2166 5933061 31.504 µM -0.975753890872766 0.156264816774702 no 2856 0.164593219647297 4165 2877375
SGTC_873 0591-4978 488 µM -0.976005787347531 0.15620177700022 no 2857 0.164530798199866 4150 3305145
SGTC_3080 9117754 49.47 µM -0.977655438186931 0.155789348528777 no 2858 0.164122384197914 4092 9550191
SGTC_2149 5554786 194.827 µM -0.977815482553395 0.155749374152055 no 2859 0.164082796072156 4086 745063 YPR165W RHO1
SGTC_2372 9071633 200 µM -0.978829187002319 0.155496337694738 no 2860 0.163832192864879 4089 21321366
SGTC_2638 epoxomicin 18 µM -0.979449267407863 0.155341689709686 no 2861 0.163679022038781 4052 9915668 A protesome inhibitor.
SGTC_419 nsc-638432 893 µM -0.980747305332373 0.155018287933314 no 2862 0.163358684818903 4021 368090
SGTC_1515 3460-0031 42.1 µM -0.980855152442827 0.154991438207863 no 2863 0.163332088029172 4006 2876596
SGTC_850 0388-0143 75.9 µM -0.981949608951021 0.154719134943854 no 2864 0.163062337024652 4026 67273
SGTC_2439 5492030 7.2 µM -0.982080110198966 0.15468668704272 no 2865 0.163030191679205 4056 5722370
SGTC_1290 0986-0249 10.2 µM -0.982819801299603 0.154502854826277 no 2866 0.162848067241754 3949 53329
SGTC_1555 citronellol 128 µM -0.983097560379818 0.154433861878784 no 2867 0.162779712447556 4031 8842 A terpine precursor.
SGTC_1798 st045719 60.953 µM -0.984749646162268 0.154023919001948 no 2868 0.162373529968761 3943 3980186
SGTC_1316 1272-0050 65.9 µM -0.985626316287825 0.15380667775397 no 2869 0.162158259642741 4029 7340392
SGTC_676 falcarinol 140 µM -0.985796550666655 0.153764516737057 no 2870 0.162116479376096 4074 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1926 methyl fluorone black 53.6 µM -0.986624370474873 0.153559604199494 no 2871 0.16191340923591 3809 72721 Reacts with homocysteine.
SGTC_820 1582-0060 59.9 µM -0.987189200309134 0.15341989413509 no 2872 0.161774947574774 4095 3848840
SGTC_2800 7887935 81.82 µM -0.98763274357638 0.153310243212465 no 2873 0.161666272049702 4100 2961002
SGTC_2959 9079155 11 µM -0.990025731277778 0.152719554670152 no 2874 0.161080771114922 4132 16189457
SGTC_21 0849-0113 22.993 µM -0.990349695636394 0.15263970301201 no 2875 0.161001612065034 4037 1560156
SGTC_300 r073-0011 5.04 µM -0.990510472122263 0.152600084651408 no 2876 0.160962336573268 4071 2735780
SGTC_925 2064-1272 59.6 µM -0.991061657331978 0.152464314003038 no 2877 0.160827737054761 4058 6815817
SGTC_1119 parthenolide 318.541 nM -0.992972522528239 0.151994241171989 no 2878 0.160361672612895 4203 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1479 0549-0158 134 µM -0.99882931864443 0.150559472154547 no 2879 0.158938690357022 4125 5440202
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.00110267524856 0.150004994713527 no 2880 0.158388585907844 4139 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.00282006886403 0.149587021986339 no 2881 0.157973841994944 4134 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3323 9138564 53.9225 µM -1.00410345382776 0.149275184494015 no 2882 0.157664375421867 4112 43912313 YNL103W MET4
SGTC_540 1187-0821 17.3 µM -1.00682361687163 0.148615673883672 no 2883 0.157009771659385 4044 847520
SGTC_741 4582-0002 126 µM -1.0083490997275 0.148246670422179 no 2884 0.156643449706554 4076 2912688
SGTC_32 0928-0142 34.1 µM -1.01305574456947 0.147112032387606 no 2885 0.155516767627911 4093 2244242
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.01450793180803 0.146763129870529 no 2886 0.155170223279265 4149 688798
SGTC_286 k060-0067 22.9 µM -1.01585828358202 0.146439192869249 no 2887 0.154848438315245 4103 5985051
SGTC_1398 3558-0053 112 µM -1.01633397227551 0.146325193928565 no 2888 0.15473518812644 4018 4532369
SGTC_3265 9137266 49.47 µM -1.01863531882298 0.145774517191931 no 2889 0.154188065116257 4016 17224265
SGTC_2447 5741742 33.78 µM -1.02107621930644 0.145191971500626 no 2890 0.153609164461162 4165 1776504
SGTC_1001 4048-4355 44.4 µM -1.02194715391907 0.14498449382294 no 2891 0.15340295647363 4087 21824233
SGTC_3340 9146634 11.102 µM -1.0224324668344 0.144868967191109 no 2892 0.153288130313667 4128 4907387
SGTC_379 3970-0972 5.9 µM -1.0256055623559 0.144115153269101 no 2893 0.152538772259926 4112 2898042 YBL034C STU1
SGTC_2704 st078022 71.1 µM -1.02589063746948 0.144047559342098 no 2894 0.152471568137807 4179 54697681
SGTC_476 mead acid 10 µM -1.02598623283378 0.144024897590985 no 2895 0.152449036713769 4150 5312531 An omega 9 fatty acid.
SGTC_2909 7941780 10.49 µM -1.02694280201131 0.143798266565597 no 2896 0.152223699079102 4089 1243215
SGTC_1924 st058459 75.1 µM -1.02751170574871 0.143663595662009 no 2897 0.152089788160378 4080 688683
SGTC_1067 clotrimazole 1.36 µM -1.02793246599227 0.143564048060859 no 2898 0.151990798213032 4149 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1275 0867-0008 21.1 µM -1.02838319518118 0.143457461775162 no 2899 0.151884805123797 4089 3422836
SGTC_1319 1306-0155 43.7 µM -1.02910639674681 0.143286554178366 no 2900 0.151714840297009 4174 3122360
SGTC_2228 7354201 200 µM -1.0295857432699 0.143173350413346 no 2901 0.151602255288491 4161 753451
SGTC_1999 st074831 12.5 µM -1.03091463840292 0.142859830930172 no 2902 0.15129042568612 4079 17112523
SGTC_970 1315-0089 19.5 µM -1.03221141581434 0.142554336470493 no 2903 0.1509865441677 4067 6811083 YLR033W RSC58
SGTC_1087 pterostilbene 9.05 µM -1.03497097624187 0.141905711295894 no 2904 0.150341232898137 4176 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1060 3448-7350 82 µM -1.03574814089601 0.141723402615589 no 2905 0.150159828460827 4093 570178
SGTC_3260 9137109 49.47 µM -1.03608099117409 0.141645370542319 no 2906 0.15008217976557 4063 17478346
SGTC_2172 5754775 163.918 µM -1.03885413395662 0.140996377613814 no 2907 0.149436290189604 4095 2263357
SGTC_1932 st074806 40.9 µM -1.0389817468877 0.140966561239003 no 2908 0.14940661272679 4211 17251235
SGTC_302 1094-0063 18.9 µM -1.04068218481834 0.140569667236688 no 2909 0.149011537054841 4109 5440289
SGTC_134 0269-0018 6.916 µM -1.04266214877168 0.140108486584 no 2910 0.148552397159138 4111 4378915
SGTC_1323 1348-1351 11.2 µM -1.04269157523719 0.140101640222052 no 2911 0.148545580507396 4078 6989654
SGTC_1482 3346-2049 8.48 µM -1.04288542623038 0.140056544527247 no 2912 0.148500680079444 4137 3826804
SGTC_326 k292-0812 17.5 µM -1.04372357890466 0.139861677986882 no 2913 0.148306648757449 4119 3579357
SGTC_246 cycloheximide 667 µM -1.04445202808873 0.139692466738396 no 2914 0.148138151467364 4020 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3084 9116877 49.47 µM -1.04490540462549 0.139587222337059 no 2915 0.148033345821354 4074 27241325
SGTC_897 1000-0139 31.4 µM -1.04602036293942 0.139328631287628 no 2916 0.14777581550476 4089 6151020
SGTC_1162 k048-0130 20.1 µM -1.04654806165504 0.139206356413845 no 2917 0.147654033615969 4096 6797406
SGTC_1685 st024049 53.0905 µM -1.04796731715913 0.138877858271713 no 2918 0.147326832550479 4166 1941139
SGTC_2783 7738165 71.43 µM -1.04938859573931 0.138549421258196 no 2919 0.146999652412113 4143 17201110
SGTC_625 k213-0058 121 µM -1.05003900853176 0.138399296880432 no 2920 0.146850089194756 4200 3655420
SGTC_2997 9067075 71.4286 µM -1.05019779772919 0.138362662954059 no 2921 0.146813590932251 4150 27209819
SGTC_1143 3454-2408 5.08 µM -1.05066829051755 0.138254155346257 no 2922 0.146705482220738 4131 X1143
SGTC_2553 4-methylesculetin 85.09 µM -1.05074181129882 0.138237204825762 no 2923 0.146688593617673 4170 5319502
SGTC_1299 1079-1439 3.74 µM -1.05233617363889 0.137869966483062 no 2924 0.14632267040859 4110 323161
SGTC_2136 5328288 199.296 µM -1.05316123277457 0.137680187587914 no 2925 0.146133551376317 4134 262395
SGTC_1111 tnp00062 510.699 nM -1.05431580342956 0.137414914362082 no 2926 0.145869177878644 4197 676306
SGTC_1208 2323-2347 50.3 µM -1.05568560863667 0.137100641926737 no 2927 0.145555937131564 4165 5412760
SGTC_2293 7624732 200 µM -1.05773230867076 0.136631986096494 no 2928 0.145088750596246 4037 894453
SGTC_1327 1436-0082 2.18 µM -1.0592275949369 0.136290286936555 no 2929 0.144748070288472 4160 15992205
SGTC_138 0850-0259 40.9225 µM -1.06043615981983 0.13601453626827 no 2930 0.144473109484182 4099 6813004
SGTC_1355 1499-0035 1.68 µM -1.06161866263938 0.135745101924149 no 2931 0.144204418920874 4153 1548538
SGTC_1820 st053765 18.6 µM -1.06571496977676 0.13481458235469 no 2932 0.143276254254439 4222 3690829
SGTC_2748 diazoxide 86.69 µM -1.0669635107748 0.134531835321311 no 2933 0.142994156760313 4216 3019 A potassium channel activatior.
SGTC_1335 1486-0900 202 µM -1.0699155372999 0.13386493356566 no 2934 0.142328664384739 4156 X1335
SGTC_581 0958-0271 211 µM -1.07149826506163 0.133508311716961 no 2935 0.141972725189317 4156 4591145
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.07268860236323 0.133240534557827 no 2936 0.141705427947885 4170 229346 A bile salt which induces apoptosis.
SGTC_198 3454-2873 16.191 µM -1.07349848823587 0.133058554792578 no 2937 0.141523758297096 4146 710957
SGTC_783 0848-0141 92.7 µM -1.07366142263605 0.133021964434005 no 2938 0.1414872287233 4094 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2109 5483026 200 µM -1.07448003739469 0.132838232036523 no 2939 0.141303793591912 4164 759335
SGTC_154 3389-1638 511.116 µM -1.07665024359702 0.13235199032752 no 2940 0.140818274419017 4162 5238686
SGTC_2518 prenyletin 46.28 µM -1.07669529971719 0.132341908373445 no 2941 0.140808206458396 4140 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_50 0929-0078 56.389 µM -1.07791036499596 0.132070219668304 no 2942 0.140536879695389 4021 1377751
SGTC_2911 7942208 15.64 µM -1.0787136994738 0.131890805352378 no 2943 0.140357688348083 4203 1243384
SGTC_2246 7293507 91.5585 µM -1.07894242323029 0.131839753636767 no 2944 0.140306697740739 4219 887656
SGTC_1476 4112-3294 3.34 µM -1.0798313345744 0.131641475848816 no 2945 0.140108647456316 4180 704369
SGTC_1338 1486-1223 76 µM -1.08246928400456 0.131054275013744 no 2946 0.13952202837572 4189 3444526
SGTC_1268 0828-0275 2.46 µM -1.08308902800849 0.130916584480851 no 2947 0.13938445428479 4222 745337
SGTC_2008 4012253 172 µM -1.08365507540308 0.130790911276609 no 2948 0.139258880717721 4171 603940
SGTC_3013 9080133 71.4286 µM -1.08558139151433 0.130363857595807 no 2949 0.138832118135458 4264 17050193
SGTC_1395 3486-0190 4.35 µM -1.08562170360633 0.130354930942709 no 2950 0.138823196782783 4167 6748079
SGTC_2074 5212007 75.395 µM -1.08580652342055 0.130314010115567 no 2951 0.138782299841615 4077 758611
SGTC_1747 st037496 66.6 µM -1.0863871483633 0.130185512165374 no 2952 0.138653872499704 4152 723305
SGTC_3090 9117696 49.47 µM -1.08653615412197 0.130152549883086 no 2953 0.138620927254039 4141 7923821
SGTC_532 1548-0774 215 µM -1.08660949094651 0.130136328811472 no 2954 0.138604714404952 4300 5932993
SGTC_2213 7173844 200 µM -1.08681861686249 0.130090080790379 no 2955 0.138558489242622 4141 892728
SGTC_183 3914-0051 30.55 µM -1.0872793696097 0.12998822584873 no 2956 0.13845668159039 4206 1596232
SGTC_895 0964-0006 13.7 µM -1.08738027373513 0.129965927147441 no 2957 0.138434392681196 4148 6738897
SGTC_228 caffeine 993.056 µM -1.09021784672245 0.129339938812885 no 2958 0.137808596820929 4204 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_110 0850-0284 111.64 µM -1.09025079779155 0.129332681872351 no 2959 0.137801341176305 3990 3906265
SGTC_2199 6590217 200 µM -1.09103010203996 0.129161134955505 no 2960 0.137629818632538 4075 703109
SGTC_324 1315-0088 19.6 µM -1.09740241803106 0.127764325917931 no 2961 0.136232758434687 4158 6787421
SGTC_1450 4112-4260 37.6 µM -1.09767175593701 0.127705519309012 no 2962 0.136173923583532 4190 1633175
SGTC_2205 7238770 200 µM -1.09914179525966 0.12738488594961 no 2963 0.135853110970528 4255 279867
SGTC_1513 0337-0559 19 µM -1.10219254248214 0.126721268842598 no 2964 0.135188986710173 4175 775073
SGTC_1469 k284-2957 126 µM -1.10315330089455 0.126512778161508 no 2965 0.134980298634866 4190 23884841
SGTC_1034 k072-0165 12.7 µM -1.10343936562125 0.126450746490083 no 2966 0.134918204709101 4224 5835461
SGTC_1137 ixabepilone 100 µM -1.10607451631965 0.125880324128441 no 2967 0.134347133888143 4154 154225 A novel microtubule stabilizer.
SGTC_2916 7875993 68.79 µM -1.10658491493145 0.125770047609385 no 2968 0.134236716153417 4036 1299250
SGTC_1769 st044406 64.4 µM -1.10698185369324 0.125684331775743 no 2969 0.134150886998064 4172 670903
SGTC_936 3005-4620 401 µM -1.1090083829487 0.125247353786055 no 2970 0.133713282820739 4266 777207
SGTC_276 colchicine 750 µM -1.1096328806516 0.125112908187818 no 2971 0.133578628219605 4269 2833 A microtubule depolymerizer.
SGTC_1272 0839-0021 27 µM -1.1110921383909 0.124799143474771 no 2972 0.133264345731895 4224 5027250
SGTC_2314 7727897 200 µM -1.11349518107373 0.124283648359475 no 2973 0.132747908410296 4212 900724
SGTC_496 calpeptin 138 µM -1.11387158430115 0.124203038320525 no 2974 0.13266714071201 4211 73364 A calpain inhibitor.
SGTC_180 1486-1293 102.781 µM -1.11421659937842 0.124129182460761 no 2975 0.132593137946297 4112 4140536
SGTC_3 0833-0587 95.581 µM -1.11514603822448 0.123930374471261 no 2976 0.132393922822094 4090 5382644
SGTC_1954 st077032 68.9 µM -1.12059638025731 0.122769025532669 no 2977 0.131229853246252 4174 698907
SGTC_2616 abietic acid 100 µM -1.12212695107773 0.122444271392699 no 2978 0.130904233092542 4263 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2432 5630864 12.22 µM -1.12220402250972 0.122427934453366 no 2979 0.130887851366349 4252 5714970
SGTC_3003 9075612 71.4286 µM -1.12470612817793 0.121898390377389 no 2980 0.130356792005509 4237 6501993
SGTC_2540 epiandrosterone 100 µM -1.12792546258298 0.121219422164134 no 2981 0.129675699688454 4265 441302 A steroid.
SGTC_2288 7946289 167.31 µM -1.12861308499273 0.121074745727519 no 2982 0.129530544191686 4292 1246052
SGTC_2054 5233173 129 µM -1.12881759261105 0.12103174056773 no 2983 0.129487394833755 4261 6889
SGTC_3313 9133968 57.047 µM -1.13185438728111 0.120394408485712 no 2984 0.128847828910263 4223 1494643
SGTC_3077 9117319 49.47 µM -1.13626693961824 0.119472564844917 no 2985 0.127922431325083 4213 17154678
SGTC_2036 5160441 105 µM -1.13828941793333 0.11905170951062 no 2986 0.127499825615424 4199 134534 YIL048W NEO1
SGTC_377 3970-0964 33.1 µM -1.1400316596963 0.118690008416081 no 2987 0.127136555720441 4177 16481235
SGTC_640 3381-0960 37.1 µM -1.14074754346613 0.11854161141459 no 2988 0.126987497782939 4298 1745025
SGTC_442 cape 100 µM -1.14148784237624 0.118388291302922 no 2989 0.126833484212792 4235 5281787
SGTC_2264 7948757 110.76 µM -1.14251436511162 0.118175924641078 no 2990 0.126620139206256 4196 2971411
SGTC_2225 6654152 15.4 µM -1.14880879105408 0.116879625700635 no 2991 0.125317416807449 4136 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1973 st070275 50.2 µM -1.1491236868894 0.116815040571011 no 2992 0.125252491229352 4183 17118334
SGTC_1091 telmisartan 47.6 µM -1.15100472874635 0.1164297658373 no 2993 0.124865145072703 4272 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_12 0849-0099 9.267 µM -1.15337309908325 0.115945959636521 no 2994 0.124378639054128 4155 6071388
SGTC_1790 st045711 43.5 µM -1.15357247758518 0.115905296207391 no 2995 0.124337743687612 4251 585119
SGTC_418 lividomycin a 100 µM -1.15373872855596 0.115871396911492 no 2996 0.124303650439546 4263 72394 An antibiotic.
SGTC_1310 1188-0297 994 nM -1.15593694572019 0.115423832713232 no 2997 0.123853474605016 4119 1588352
SGTC_1179 1021-1431 9.29 µM -1.15652391138117 0.115304532677965 no 2998 0.123733462406896 4258 2840958
SGTC_2438 5259590 200 µM -1.1568030193925 0.115247835081508 no 2999 0.123676423984032 4261 1201127
SGTC_1274 0865-0114 173 µM -1.16059357580487 0.114479788609 no 3000 0.122903609598598 4241 870624
SGTC_2920 7982904 15.77 µM -1.160847441485 0.1144284805727 no 3001 0.122851972998417 4254 6456808
SGTC_1509 1326-1131 80 µM -1.16512687707968 0.113566039529528 no 3002 0.121983819466631 4221 768313
SGTC_563 tetrahydrosecaminediol 614 µM -1.1658765375614 0.113415437639736 no 3003 0.121832183184397 4300 334274 A psychoactive constituent of the cannabis plant.
SGTC_1966 st070145 16.1 µM -1.16610661232534 0.113369245701533 no 3004 0.121785671776767 4240 3748532
SGTC_812 4251-0442 148 µM -1.17171607667248 0.112247186976088 no 3005 0.120655533137688 4285 5723007
SGTC_568 1193-0097 7.48 µM -1.17219910223352 0.112150940028128 no 3006 0.120558564388979 4077 3646150
SGTC_1309 pyrazolanthrone 13.4 µM -1.17791677572407 0.11101612479175 no 3007 0.119414893238562 4241 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1366 1683-0113 21.9 µM -1.17951785963552 0.110699828707184 no 3008 0.119096014667797 4264 708623
SGTC_1147 3809-1045 12.3 µM -1.18177513809791 0.110254998415797 no 3009 0.118647467600762 4268 325925
SGTC_333 3486-0131 40.1 µM -1.18184510004631 0.110241231885401 no 3010 0.118633584457517 4305 6744690
SGTC_2216 7189485 200 µM -1.18431250536895 0.109756504577745 no 3011 0.118144690190955 4275 731273
SGTC_1252 0493-0875 34.8 µM -1.18608111608227 0.109409999643509 no 3012 0.117795133627693 4249 3960963
SGTC_3066 9117245 49.47 µM -1.18758971400454 0.109115057751254 no 3013 0.11749754612022 4323 17176980
SGTC_2259 7964009 200 µM -1.19348933682893 0.10796712549103 no 3014 0.116338892901691 4312 313134
SGTC_1300 1094-0077 113 µM -1.19548487463007 0.107580814494418 no 3015 0.115948821157277 4245 5532636
SGTC_1435 4092-0789 56.7 µM -1.20542954591145 0.105670498002434 no 3016 0.114018760587639 4274 2248285
SGTC_1413 3910-0535 34.4 µM -1.20607368335084 0.105547613918623 no 3017 0.113894540472369 4316 2876951
SGTC_162 k030-0015 37.8 µM -1.20711929513324 0.105348359424668 no 3018 0.113693102526212 4366 1809920 YMR134W ERG29
SGTC_1331 1472-0049 76.2 µM -1.20753412470278 0.105269383867472 no 3019 0.11361325568316 4248 24051409
SGTC_3349 9149703 23.001 µM -1.20765350077324 0.10524666490295 no 3020 0.113590285457867 4302 4910494
SGTC_104 0074-0074 590.992 µM -1.2092592551039 0.104941411759309 no 3021 0.11328162957129 4090 3943124
SGTC_3188 9110789 49.47 µM -1.21044413039599 0.104716578840888 no 3022 0.113054258412271 4284 849217
SGTC_1393 3470-5649 58.2 µM -1.21069850060662 0.104668357004568 no 3023 0.113005488638007 4260 4108395
SGTC_951 1171-0579 82.7 µM -1.21524761604696 0.103808679841178 no 3024 0.112135832284715 4253 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_809 3998-0021 90 µM -1.21568275454837 0.103726717946845 no 3025 0.112052898042055 4253 715485
SGTC_1216 1165-0504 9.65 µM -1.22163690475491 0.102609918188096 no 3026 0.110922483085711 4310 6304004
SGTC_759 3486-0358 89.3 µM -1.22399949526317 0.102169205908738 no 3027 0.110476208968475 4311 875103
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.22446464355795 0.102082600682234 no 3028 0.110388498114028 4308 3256 An antibiotic and ribosome inhibitor.
SGTC_1563 conessine 56.1 µM -1.22612677886319 0.101773566789973 no 3029 0.110075484990537 4387 441082 An anti-amoebic, histamine inhibitor.
SGTC_2075 5212009 200 µM -1.2300916894948 0.10103913863158 no 3030 0.10933138587284 4232 780898
SGTC_893 0958-0369 48.9 µM -1.23156032429677 0.100768083353085 no 3031 0.10905668473765 4227 6819948
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.2331356281823 0.100477930804705 no 3032 0.108762583448477 4349 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1390 3413-2614 145 µM -1.23846821187338 0.0995002561667919 no 3033 0.107771250903172 4334 3421432
SGTC_3025 9087895 49.47 µM -1.24078966137544 0.0990768212525902 no 3034 0.107341730737435 4286 17173641
SGTC_1044 1222-0021 1.78 µM -1.242228704704 0.0988150007792141 no 3035 0.107076095838824 4257 4306703
SGTC_1058 3448-5425 97.3 µM -1.24238515132992 0.0987865673202755 no 3036 0.107047245748636 4263 7279705
SGTC_2517 totarol 10 µM -1.24534709000305 0.0982493777321825 no 3037 0.106502096562182 4315 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.24664247115309 0.0980151156835079 no 3038 0.106264310763237 4310 75037 A free radical scavenger.
SGTC_1374 2889-5571 141 µM -1.25287850279791 0.0968930926090065 no 3039 0.105124963222836 4356 2853281
SGTC_3058 9093861 49.47 µM -1.25681086258403 0.0961904247504878 no 3040 0.104411065842246 4353 17217477
SGTC_2326 6164455 177.58 µM -1.2584505709458 0.0958985368064435 no 3041 0.10411442631197 4285 2888790
SGTC_1913 st060213 96.1 µM -1.25887938296217 0.0958223106432289 no 3042 0.104036950844167 4346 688959
SGTC_2756 carbadox 75.1 µM -1.26072944075903 0.0954939529508097 no 3043 0.103703171498954 4271 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1183 1254-0324 198 µM -1.2612169850114 0.0954075591476904 no 3044 0.103615340384971 4406 5799357
SGTC_2012 4023501 200 µM -1.26187684671153 0.0952907220035138 no 3045 0.103496552261058 4342 3477460
SGTC_731 3966-0296 387 µM -1.26200804973051 0.0952675033537835 no 3046 0.103472944913926 4339 660956
SGTC_1184 1269-1718 139 µM -1.26252391840491 0.0951762518320707 no 3047 0.103380162604336 4382 5403821
SGTC_608 k048-0125 159 µM -1.26272889786966 0.0951400110830817 no 3048 0.103343312496434 4372 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_757 1066-0008 322 µM -1.26524926388115 0.0946952361266998 no 3049 0.102890993878105 4374 6842497
SGTC_558 k064-0027 21.3 µM -1.27057315373235 0.0937607577735298 no 3050 0.101940271343886 4343 5088526
SGTC_441 propafenone 146 µM -1.27219729178903 0.0934770398243153 no 3051 0.101651514815821 4330 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2340 7987427 183.45 µM -1.27420593464862 0.0931270310526929 no 3052 0.101295221263577 4360 2239331
SGTC_2222 6885208 172.143 µM -1.27692789019946 0.0926542734135993 no 3053 0.100813853268645 4335 609514
SGTC_842 0271-0008 11.1 µM -1.27843264834649 0.0923936854813287 no 3054 0.100548459257609 4389 1221709
SGTC_3353 9151644 39.2805 µM -1.27874281971681 0.0923400387390596 no 3055 0.100493817787254 4350 4909158
SGTC_2670 beta-carotene 100 µM -1.2797272098153 0.0921699328843195 no 3056 0.100320545782593 4302 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2449 5812982 45.77 µM -1.28488619954326 0.0912822346599273 no 3057 0.0994160270735457 4282 776185
SGTC_1819 st053448 58.6 µM -1.28613337874431 0.0910685892990127 no 3058 0.099198258384252 4260 2857616
SGTC_1948 st076329 66.6 µM -1.28787318966667 0.0907711745743598 no 3059 0.0988950547791736 4273 24208413
SGTC_2481 5478948 45.16 µM -1.28907117774088 0.0905668020421557 no 3060 0.0986866712970986 4367 77792
SGTC_2018 5133068 143 µM -1.2891263776631 0.0905573933694699 no 3061 0.098677077323208 4318 785362
SGTC_1683 st010134 710 nM -1.30088511393128 0.0885696504433949 no 3062 0.0966488911093042 4345 3818134
SGTC_355 1311-2252 105 µM -1.30210354384337 0.0883655553210534 no 3063 0.0964404959425936 4342 5338538
SGTC_902 1120-0002 2.07 µM -1.30239097910265 0.0883174591320498 no 3064 0.0963913823832721 4360 3280475
SGTC_2863 9028737 58.44 µM -1.30406162660521 0.0880382979055602 no 3065 0.0961062856019703 4363 6460917
SGTC_856 0433-0016 11.3 µM -1.30465421962848 0.0879394352585121 no 3066 0.0960053084227242 4402 3911780
SGTC_1734 st037168 69.4 µM -1.30468428348598 0.087934421894783 no 3067 0.0960001876556776 4376 708907
SGTC_422 cantharidin 155 µM -1.30622590296952 0.0876776313925088 no 3068 0.0957378732537072 4282 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1628 st004252 77.7 µM -1.30913765303277 0.0871941426085432 no 3069 0.0952438633934266 4382 692968
SGTC_3158 9100007 49.47 µM -1.31173282696654 0.0867649008732131 no 3070 0.0948051482928356 4388 19297233
SGTC_3112 9123419 49.47 µM -1.31234655955066 0.086663620766406 no 3071 0.0947016146405915 4429 17015854
SGTC_2502 avocadyne acetate 18.59 µM -1.31449396337367 0.0863099447664222 no 3072 0.0943400141150859 4322 3952079
SGTC_844 0330-0132 15.3 µM -1.31470448623154 0.0862753299726206 no 3073 0.094304619130105 4436 2828079
SGTC_1133 3473-0247 50 µM -1.31703166236835 0.0858933802487537 no 3074 0.0939140058213418 4342 711311
SGTC_1697 st025554 27.742 µM -1.32043653562107 0.0853368348112918 no 3075 0.0933446560225303 4396 1269519
SGTC_2305 7443522 69.23 µM -1.32471070352216 0.0846420278211875 no 3076 0.0926335608579939 4279 5415886
SGTC_2330 7979373 200 µM -1.32610738280495 0.0844159064468156 no 3077 0.0924020655235615 4313 1863007
SGTC_1123 mangostin 811.285 nM -1.33181800134351 0.0834960751928338 no 3078 0.0914600005826116 4384 5281650 An antioxidant.
SGTC_2569 tetrandrine 100 µM -1.33258640041237 0.0833728833699839 no 3079 0.0913337852606444 4386 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.33524402920286 0.0829478584829555 no 3080 0.090898245379312 4494 16725076
SGTC_1554 st069299 38.7 µM -1.33590523438001 0.0828423679830229 no 3081 0.0907901249298595 4350 24207999
SGTC_1880 MG-132 525 µM -1.33632276514225 0.0827758059855413 no 3082 0.090721899362271 4347 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2867 9039098 71.43 µM -1.33894171634147 0.0823592150969103 no 3083 0.0902948238259677 4373 6463460
SGTC_2836 9010338 19.48 µM -1.33985059500785 0.0822150113569919 no 3084 0.0901469614323886 4364 2994051
SGTC_1381 2324-0066 62.1 µM -1.33986313976443 0.0822130223227964 no 3085 0.0901449218276581 4423 10885928
SGTC_877 0771-0151 33.1 µM -1.3401000769395 0.0821754615497187 no 3086 0.0901064055427991 4402 6166523
SGTC_2299 7976368 114.88 µM -1.3404669158324 0.0821173334390568 no 3087 0.0900467966772593 4420 2979718
SGTC_312 4092-0653 6.84 µM -1.34048762319562 0.0821140531407262 no 3088 0.0900434327431334 4286 1148278
SGTC_2277 7947813 106.88 µM -1.34161856861551 0.081935047504525 no 3089 0.0898598511857785 4420 1246798
SGTC_2271 7849410 118.62 µM -1.34312478021155 0.0816971016820536 no 3090 0.0896157864289361 4325 972430
SGTC_2186 6124449 200 µM -1.34443122640619 0.0814911362710495 no 3091 0.0894044909000661 4401 3834182 YLR033W RSC58
SGTC_1732 st034308 51.822 µM -1.34491275844222 0.0814153200555664 no 3092 0.0893267047921436 4279 830119
SGTC_1363 1636-0063 10.4 µM -1.34534604675387 0.081347145197904 no 3093 0.0892567549620973 4401 6072185
SGTC_1723 st034307 2.5525 µM -1.34578836799653 0.0812775935000586 no 3094 0.0891853889075316 4402 867466
SGTC_1117 retinoic acid 1.10837 µM -1.3528650197498 0.0801709352531527 no 3095 0.0880493781436667 4438 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_656 4090-1979 187 µM -1.35442835174739 0.0799280020107623 no 3096 0.0877998787225577 4422 22330961
SGTC_2145 5634607 200 µM -1.35487763240386 0.0798582893330857 no 3097 0.0877282735816403 4386 308662
SGTC_1559 coumarin 343 70.1 µM -1.35658115519075 0.0795943797415754 no 3098 0.0874571664433359 4446 108770 A hepatotoxic, DNA x-linker.
SGTC_2382 9035899 200 µM -1.36333452149157 0.0785546395838459 no 3099 0.0863885534797292 4403 6462679
SGTC_1733 st037357 54.9 µM -1.36365481059255 0.0785055851894079 no 3100 0.0863381163983201 4317 1272339 YGL099W LSG1
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.36676181701813 0.0780309311806232 no 3101 0.0858499872975192 4413 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_716 1683-5115 658 µM -1.36780794175974 0.0778716067653011 no 3102 0.0856861005821676 4395 723597
SGTC_3098 9119039 49.47 µM -1.3718513656623 0.0772581153959389 no 3103 0.0850548565437779 4415 17161528
SGTC_3076 9116187 49.47 µM -1.37266658483466 0.0771348716734855 no 3104 0.0849280108746354 4411 27241210
SGTC_3040 9091894 49.47 µM -1.37381405521831 0.0769616518701556 no 3105 0.0847497082653042 4277 25236966
SGTC_2683 piperine 63.03 µM -1.37421371519068 0.076901389487077 no 3106 0.0846876720389243 4425 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_361 000s-0510 1.45 µM -1.38019455031943 0.0760038540869864 no 3107 0.0837633757470508 4327 660
SGTC_3328 9140624 29.0385 µM -1.38079433521144 0.075914287082546 no 3108 0.0836711028826542 4424 4904392
SGTC_2754 granisetron 64.02 µM -1.38110541035637 0.0758678653115276 no 3109 0.0836232761520214 4419 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2719 novobiocin 32.65 µM -1.38133902952031 0.0758330165197732 no 3110 0.0835873715189015 4474 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3296 9122258 64.045 µM -1.38929517068354 0.0746534686759153 no 3111 0.0823715059070932 4395 4730474
SGTC_3054 9094397 49.47 µM -1.39543779658575 0.0737524042363611 no 3112 0.0814419301273504 4431 2598354
SGTC_1259 0671-0132 43 µM -1.39665346428814 0.0735750669263677 no 3113 0.0812589022313817 4369 X1259
SGTC_1750 st081859 2.357 µM -1.40520264090808 0.0723371390410399 no 3114 0.0799805145365963 4360 5291695
SGTC_2991 9074669 71.4286 µM -1.40527152105659 0.0723272303557133 no 3115 0.0799702767662499 4398 17333109
SGTC_3196 9111891 49.47 µM -1.407411607922 0.072019888163156 no 3116 0.0796526855558626 4412 18891510
SGTC_484 loperamide 105 µM -1.40826949215732 0.0718969671930404 no 3117 0.0795256428678253 4519 3955 An opioid-receptor agonist.
SGTC_2910 7948405 25.97 µM -1.41450222201132 0.0710087428360216 no 3118 0.0786072477144422 4398 2971328
SGTC_645 0845-0943 5.41 µM -1.41465677657673 0.0709868248862386 no 3119 0.0785845766119387 4462 1885106
SGTC_2033 5192550 145 µM -1.42373201040283 0.0697089215357506 no 3120 0.0772620318516487 4465 182073
SGTC_2155 5570423 76 µM -1.42520182502902 0.069503630561856 no 3121 0.0770494344749313 4428 797402
SGTC_2716 st080858 38.6235 µM -1.42561369212544 0.0694461881231896 no 3122 0.0769899408864105 4426 5296050
SGTC_142 0335-0849 62.6745 µM -1.42591033816799 0.0694048380340691 no 3123 0.0769471124424305 4420 3889043 YPR107C YTH1
SGTC_2516 gossypol 71.55 µM -1.427497959296 0.0691838585784592 no 3124 0.076718206487852 4467 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2893 9048488 25.97 µM -1.43878540633125 0.0676283665199063 no 3125 0.0751056662125086 4493 6467338
SGTC_3302 9125395 16.351 µM -1.43956949910287 0.0675213247470866 no 3126 0.0749946170544662 4412 17599668
SGTC_2342 7990637 118.86 µM -1.44089921695868 0.0673400953690836 no 3127 0.074806578672171 4438 2033102 YER133W GLC7
SGTC_2345 9052315 157.45 µM -1.44361714174889 0.0669708350169823 no 3128 0.0744233501807594 4463 6469265
SGTC_3015 9080845 49.47 µM -1.44879380030703 0.0662718629744089 no 3129 0.0736975878345302 4525 5296973
SGTC_965 1291-5240 308 µM -1.4494557416831 0.0661828940511405 no 3130 0.0736051758029437 4448 2834598
SGTC_1815 st051655 58.2 µM -1.45016679557747 0.0660874272036748 no 3131 0.0735060060200049 4406 5984156
SGTC_1868 st057644 42.7 µM -1.45566491190526 0.0653528421103927 no 3132 0.0727426370794649 4488 688665
SGTC_2908 7930301 100 µM -1.45568349986892 0.0653503694213506 no 3133 0.0727400666267782 4423 2223178
SGTC_1141 3253-0389 52.6 µM -1.45584897883571 0.0653283595564454 no 3134 0.0727171862898074 4451 5402031
SGTC_173 1273-0061 2.693 µM -1.45715513672956 0.0651548331589435 no 3135 0.0725367806940626 4424 2847414 YPL266W DIM1
SGTC_2462 5162487 171.77 µM -1.46804358923977 0.0637221616718986 no 3136 0.0710461915046471 4435 2259986
SGTC_295 k015-0027 31 µM -1.46968992914086 0.063507690353107 no 3137 0.0708228757565871 4540 3887424
SGTC_746 1095-0025 46.6 µM -1.47003859629957 0.0634623410955547 no 3138 0.0707756505038828 4487 6749286
SGTC_2180 6301957 200 µM -1.47113893278934 0.0633193915240926 no 3139 0.0706267739924409 4497 845462
SGTC_2467 5474540 200 µM -1.47357754731336 0.0630034738280239 no 3140 0.0702976851666162 4459 5413519
SGTC_2329 6138490 200 µM -1.47383751246092 0.06296986840306 no 3141 0.0702626727729884 4512 720019
SGTC_1231 0242-0792 125 µM -1.48159991566669 0.0619728497141518 no 3142 0.0692233907447819 4474 3707635
SGTC_906 1165-0455 526 µM -1.48536734505979 0.0614934148807667 no 3143 0.0687232705168422 4466 3252859
SGTC_3192 9110362 49.47 µM -1.48622897526251 0.0613841737865824 no 3144 0.0686092829251986 4492 16649480
SGTC_1976 st070609 63.5 µM -1.48783731117219 0.0611806678653501 no 3145 0.0683969016473401 4434 682556
SGTC_113 0099-0221 2.5 µM -1.48834336875794 0.0611167445614351 no 3146 0.0683301815966061 4455 89219
SGTC_3232 9132874 49.47 µM -1.49117625840735 0.060759868029801 no 3147 0.0679576125909743 4458 3784940
SGTC_2106 5357045 167.29 µM -1.49127881539366 0.0607469789282828 no 3148 0.067944154233428 4521 668842
SGTC_1527 coumarin 137 µM -1.49139785995084 0.0607320203924549 no 3149 0.0679285348245162 4520 323 A hepatotoxic, DNA x-linker.
SGTC_1646 st011709 75.6 µM -1.49140315313428 0.0607313553447443 no 3150 0.0679278403893115 4457 5757843
SGTC_2566 crystal violet carbinol 226 nM -1.49368439332669 0.0604452649024493 no 3151 0.067629064788222 4452 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_149 3970-0822 46.1 µM -1.4994665638982 0.0597248462246798 no 3152 0.0668763182753699 4468 3114250 YBL034C STU1
SGTC_2726 cimetidine 79.27 µM -1.49965190587798 0.0597018656515351 no 3153 0.0668522973539338 4485 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1348 1493-0373 93.8 µM -1.50340937300838 0.059237469274852 no 3154 0.0663667555212711 4521 3010129
SGTC_815 1582-0027 36.9 µM -1.50476126785202 0.0590710792664081 no 3155 0.066192732479825 4509 3128206
SGTC_2419 paclitaxel 166.5 µM -1.50489171515668 0.05905504334226 no 3156 0.0661759593291727 4439 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1064 honokiol 6.76 µM -1.50822816796829 0.0586460517574722 no 3157 0.0657480702008151 4527 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2922 7999257 32.47 µM -1.50878379449262 0.058578158021257 no 3158 0.0656770217048799 4465 2988377
SGTC_321 4534-3890 65.3 µM -1.51603561081937 0.0576976837028885 no 3159 0.0647551740490136 4503 699746
SGTC_1273 0849-0096 14.1 µM -1.52270065831394 0.0568976605440114 no 3160 0.0639168066038391 4534 5286025
SGTC_1456 k015-0012 13 µM -1.52391395378267 0.0567529698102814 no 3161 0.0637651036378495 4506 2989616
SGTC_2947 9072639 7.68 µM -1.52578826189706 0.0565300203289385 no 3162 0.0635313024628064 4447 16488146
SGTC_3102 9121669 49.47 µM -1.52829602619838 0.0562328011784787 no 3163 0.0632195280533904 4544 41905072
SGTC_1788 fluconazole 20 µM -1.52855737654761 0.056201897070347 no 3164 0.0631871046911013 4510 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_385 1494-0393 12.4 µM -1.53110864955192 0.0559009175751235 no 3165 0.0628712712348821 4481 3090647
SGTC_2532 xanthone 78.9 µM -1.53661800981201 0.0552553041553425 no 3166 0.0621934398170892 4536 7020 An insecticide.
SGTC_1813 st051246 8.6015 µM -1.54052879493535 0.0548006039948306 no 3167 0.0617157547248946 4468 5291959
SGTC_963 1269-2853 151 µM -1.54079007612368 0.0547703310044786 no 3168 0.0616839427464384 4507 3668223
SGTC_2468 5987765 72.9 µM -1.54192893239792 0.0546385333308499 no 3169 0.0615454321612551 4553 26772094
SGTC_3262 9137218 49.47 µM -1.54446079043593 0.054346424699063 no 3170 0.0612383714881947 4510 17650664
SGTC_3263 9137018 49.47 µM -1.54730826190507 0.0540193802885806 no 3171 0.0608944652255819 4475 43844957
SGTC_733 4069-0007 56.1 µM -1.54864761847995 0.0538660890804938 no 3172 0.0607332261299959 4519 5717425 YNL287W SEC21
SGTC_2223 6903751 107.57 µM -1.55290000157056 0.0533816797821494 no 3173 0.0602235132165773 4500 5598863
SGTC_2936 9038235 15.59 µM -1.55846475869976 0.0527529939568027 no 3174 0.0595615578805396 4452 4749415
SGTC_85 0868-0259 160.055 µM -1.55916702330492 0.0526740738659557 no 3175 0.0594784268313451 4467 83173
SGTC_1722 st034304 3.6505 µM -1.56247805826306 0.052303243088809 no 3176 0.0590877054537958 4472 4036148 YLR033W RSC58
SGTC_1872 amphotericin b 148 nM -1.56334157285383 0.052206872406355 no 3177 0.0589861374298649 4536 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_533 1222-0222 6.71 µM -1.56631785736958 0.0518757909021681 no 3178 0.0586371112345324 4543 3982874
SGTC_2864 9034755 47.6 µM -1.56760970326513 0.0517326064014313 no 3179 0.0584861231044615 4476 4930451
SGTC_2348 9022543 33.42 µM -1.57477080318367 0.0509445793044539 no 3180 0.057654679005679 4544 3162678 YDL140C RPO21
SGTC_391 gliotoxin 8.33 µM -1.57644173201378 0.050762087631892 no 3181 0.0574620186120398 4570 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1583 clindamycin 39.6 µM -1.57829149050328 0.0505606724617756 no 3182 0.057249329968445 4509 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_10 0279-0212 42.575 µM -1.58217755553454 0.0501396031996594 no 3183 0.056804521314072 4559 39851 YBR002C RER2
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.58358749443549 0.0499875241317803 no 3184 0.0566438107999987 4539 6708561
SGTC_459 nigericin 15.3 µM -1.58873895978804 0.0494350007831194 no 3185 0.0560596695972515 4555 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1656 st012921 11 µM -1.58921515015673 0.0493841738329962 no 3186 0.0560059136047551 4459 6732821
SGTC_1669 st015249 58.4 µM -1.58973139357403 0.0493291188952908 no 3187 0.0559476820587222 4656 722793
SGTC_3332 9141069 11.198 µM -1.59860955036071 0.0483899515214767 no 3188 0.0549536931706968 4494 17332883
SGTC_1574 spiramycin 23.7 µM -1.6023462625403 0.0479989677367058 no 3189 0.0545395304183547 4514 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_15 0266-0086 27.098 µM -1.60824621487915 0.0473867894583916 no 3190 0.053890632574587 4609 1712902 YIL048W NEO1
SGTC_2394 5221648 200 µM -1.61877515952296 0.0463098648414105 no 3191 0.0527478243347141 4576 788586
SGTC_969 1313-0238 134 µM -1.62041173218083 0.0461442509585761 no 3192 0.0525719306630332 4575 5212874
SGTC_1490 4089-0339 670 nM -1.6258479097606 0.0455975457243359 no 3193 0.0519910067941138 4558 742542
SGTC_3227 9130768 49.47 µM -1.62995714648959 0.0451877540309162 no 3194 0.0515552771857175 4633 17720899
SGTC_2935 9038016 29.96 µM -1.63622828603035 0.0445680847252798 no 3195 0.0508959092846356 4517 6463195
SGTC_2730 imipramine 71.33 µM -1.65342068324814 0.0429043069317136 no 3196 0.0491226381467456 4526 3696 A tricyclic antidepressant.
SGTC_588 3970-1144 52.9 µM -1.65668542328615 0.0425941078623754 no 3197 0.0487915457924912 4486 1888707
SGTC_2853 9015042 58.44 µM -1.66239041586076 0.0420564033625782 no 3198 0.0482172596644631 4498 6457456
SGTC_1686 st019653 115.5 µM -1.66424521046879 0.0418827742542453 no 3199 0.0480317182915576 4563 97252
SGTC_2865 9030313 51.95 µM -1.68073138806217 0.0403648639230916 no 3200 0.0464075504745182 4553 42562754
SGTC_2694 st077685 81.9 µM -1.68590477096833 0.0398978567015875 no 3201 0.0459070714341487 4507 2838096
SGTC_2097 5376186 200 µM -1.68674778873531 0.0398221742845849 no 3202 0.0458259293783412 4555 742755
SGTC_1896 st058441 89 µM -1.69041509450032 0.0394942967608946 no 3203 0.0454742846367137 4590 688759
SGTC_1521 st012942 49.4 µM -1.69878475732804 0.0387542237233631 no 3204 0.0446798733229022 4514 24207259
SGTC_2350 9023895 38.85 µM -1.70321513537772 0.0383670713591058 no 3205 0.0442639076230928 4555 2997209
SGTC_907 3448-6986 75.5 µM -1.70635198150436 0.0380948664774181 no 3206 0.0439712826266492 4599 590582
SGTC_653 0203-0016 55.2 µM -1.70837313915605 0.0379203132193717 no 3207 0.0437835640220102 4641 295302
SGTC_2364 9055074 200 µM -1.71110001406997 0.0376858468487737 no 3208 0.043531325792975 4594 6470630
SGTC_1389 3405-0187 19 µM -1.71198433033811 0.037610064815679 no 3209 0.0434497781036606 4581 799890
SGTC_210 3551-0445 56.827 µM -1.7169580537811 0.037186153101358 no 3210 0.042993418203057 4578 2865180 YOR207C RET1
SGTC_3246 9135460 32.98 µM -1.72207881618463 0.0367537965054937 no 3211 0.0425276209806007 4593 41446951
SGTC_2645 abamectin 100 µM -1.72686895323186 0.0363530853407653 no 3212 0.0420956006859679 4557 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_976 1348-1067 47.6 µM -1.73009680258643 0.0360850868201207 no 3213 0.0418064907086645 4613 5310671 YGL099W LSG1
SGTC_3178 9107506 49.47 µM -1.73600634881267 0.0355986285584252 no 3214 0.0412813559951611 4583 8897194
SGTC_2146 5545642 200 µM -1.73901803003076 0.0353527904560326 no 3215 0.0410157957647094 4565 825326
SGTC_1778 st046819 58.9 µM -1.74071702571363 0.0352147199171812 no 3216 0.0408665961979476 4638 671715
SGTC_1225 1216-0074 20.6 µM -1.74611185643295 0.0347792334894231 no 3217 0.0403957584816624 4597 4241466
SGTC_713 1488-1073 324 µM -1.74956794709895 0.0345025787528604 no 3218 0.0400964473242944 4640 3312542
SGTC_1605 st000082 49.1 µM -1.74976824740232 0.0344866006076217 no 3219 0.0400791559115999 4579 1114022
SGTC_1910 st062352 60.4 µM -1.75450514768736 0.0341105020274494 no 3220 0.0396719943145057 4534 2245730
SGTC_1009 4106-0057 9.87 µM -1.75769346573459 0.0338592610055931 no 3221 0.0393998401299359 4601 2928005
SGTC_1040 k898-0338 155 µM -1.75830416863515 0.0338113114618671 no 3222 0.0393478843916944 4594 20969351
SGTC_1322 1348-1070 12 µM -1.75999682711572 0.0336787037388264 no 3223 0.0392041722738178 4621 6758089
SGTC_458 nppb 133 µM -1.76335010761379 0.0334172618621631 no 3224 0.0389207295279011 4636 4549 A chloride channel blocker.
SGTC_130 0136-0219 337.655 µM -1.76469571003178 0.0333128215060254 no 3225 0.0388074599864562 4538 234244
SGTC_780 0109-0199 192 µM -1.76702070526774 0.0331329981098812 no 3226 0.0386123804005592 4634 610414
SGTC_2732 terfenadine 20 µM -1.77457623096111 0.0325541411553104 no 3227 0.0379839423890517 4686 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3155 9099265 49.47 µM -1.77926696969001 0.0321989814883732 no 3228 0.0375980017323985 4598 25236499
SGTC_924 2046-0044 21.3 µM -1.79398970924083 0.0311049658815864 no 3229 0.0364074056881658 4594 3623589
SGTC_3333 9141820 12.094 µM -1.79895795500358 0.0307427983485724 no 3230 0.0360126659194817 4612 1939433
SGTC_1627 st003713 25.6 µM -1.80072610159469 0.0306147520375858 no 3231 0.0358730307277418 4630 16195070 YER133W GLC7
SGTC_2360 9040895 200 µM -1.81238551914147 0.0297814119873577 no 3232 0.034963324385985 4641 4914414
SGTC_2128 5255449 168.493 µM -1.81513924268314 0.0295873652213083 no 3233 0.0347512569129627 4545 736008
SGTC_2429 5902844 64.44 µM -1.82616670385348 0.0288207785585089 no 3234 0.0339125775383221 4620 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2985 9022375 71.43 µM -1.82886704163103 0.0286355993087695 no 3235 0.0337097643370602 4627 4939335
SGTC_2179 6298986 200 µM -1.83132822082824 0.0284676836679826 no 3236 0.0335257839329844 4602 738374
SGTC_3094 9117742 49.47 µM -1.84311030237874 0.0276751510442782 no 3237 0.0326564537225988 4609 17149698
SGTC_2006 4011487 200 µM -1.85568961249928 0.0268493757357052 no 3238 0.0317489061264705 4583 45595294
SGTC_1407 3909-7909 12.3 µM -1.85762765287925 0.0267239996415829 no 3239 0.031610954396832 4661 4411780
SGTC_977 1348-1378 135 µM -1.86821415728593 0.0260477354997675 no 3240 0.0308661131131465 4633 X977
SGTC_1070 indatraline 8.81 µM -1.87581116647549 0.0255713110541878 no 3241 0.0303406070609017 4685 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2636 apigenin dimethyl ether 100 µM -1.88758716158305 0.0248472469334085 no 3242 0.0295406974770468 4607 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1785 bathophenanthroline 24 µM -1.9088181507601 0.0235852658622797 no 3243 0.0281427772745462 4584 72812 An iron chelator.
SGTC_1368 1852-0141 284 µM -1.9100035630594 0.0235164229431867 no 3244 0.0280663772791113 4619 2838987
SGTC_2906 7926292 26.41 µM -1.91917839682885 0.0229892901275058 no 3245 0.0274808802780537 4637 2966319
SGTC_1859 st055998 20 µM -1.91976419922442 0.0229559740357858 no 3246 0.0274438454415431 4606 676301
SGTC_2294 7971431 200 µM -1.92895846767531 0.0224383780118484 no 3247 0.026868009214849 4652 5741572
SGTC_215 1287-0124 461.5 µM -1.94465145297194 0.0215776726555306 no 3248 0.0259084710743735 4715 5560863
SGTC_2887 9044784 58.44 µM -1.94662004619195 0.0214716980119147 no 3249 0.0257901517454503 4595 6465546
SGTC_2078 5212016 200 µM -1.94817503446724 0.0213883001492448 no 3250 0.0256970114934967 4596 1899708
SGTC_112 phenothiazine 287.218 µM -1.95001648345377 0.0212898930434847 no 3251 0.0255870772108435 4647 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2265 7929201 200 µM -1.95446317757572 0.0210538391197794 no 3252 0.0253232327383715 4655 1265108
SGTC_2344 7990960 76.95 µM -1.96184973690947 0.0206666171882336 no 3253 0.0248899905594424 4648 140813
SGTC_2785 7756463 72.73 µM -1.96551061822139 0.0204769509775066 no 3254 0.0246775839652917 4651 2201551
SGTC_762 1165-0429 115 µM -1.97525836606317 0.0199791094810206 no 3255 0.0241194176903369 4687 5967793
SGTC_396 dithiazanine 1.25 µM -1.98906899994516 0.0192913729717295 no 3256 0.0233467937348205 4661 10578 An antihelmenthic.
SGTC_2243 6634756 200 µM -1.99885241721968 0.018816447011066 no 3257 0.0228121621956488 4680 885676
SGTC_2217 6934799 96.0675 µM -2.00256696348951 0.018638752223197 no 3258 0.022611894414717 4669 675606
SGTC_975 1335-0046 28.5 µM -2.01857453098274 0.0178892424418175 no 3259 0.0217657302051371 4688 16486740
SGTC_1663 st014140 55.4 µM -2.0194356562669 0.0178496618830222 no 3260 0.0217209793397988 4725 4207120
SGTC_77 0828-0286 12.516 µM -2.027134969341 0.0174990803797765 no 3261 0.0213243057413829 4596 745345
SGTC_237 nikkomycin 200 µM -2.02921488595993 0.0174053878806354 no 3262 0.0212182040120814 4694 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3319 9138450 16.7555 µM -2.03559375848355 0.0171207105188128 no 3263 0.020895582531153 4655 2029690
SGTC_596 1155-0152 116 µM -2.03970098493603 0.0169395261826729 no 3264 0.0206900583848702 4707 280313
SGTC_2333 9017922 200 µM -2.05782455571363 0.0161594817584146 no 3265 0.0198034889882779 4661 3163164
SGTC_2634 4'-methoxyflavone 100 µM -2.06052878973094 0.0160457707704333 no 3266 0.0196740082478343 4666 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2617 dihydrotanshinone i 20.83 µM -2.07170254945676 0.0155831651757749 no 3267 0.0191465947227062 4654 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3283 9109332 35.8195 µM -2.07183939822604 0.0155775711909264 no 3268 0.0191402105594814 4559 17027281
SGTC_1012 4112-3522 18 µM -2.08902819459444 0.0148885081524051 no 3269 0.0183525926199129 4695 3112398
SGTC_3141 9094609 49.47 µM -2.09600874205892 0.0146162478613409 no 3270 0.0180407077283712 4663 25236309 YDL196W YDL196W
SGTC_810 3825-7150 143 µM -2.10779221408692 0.0141663769720231 no 3271 0.0175244833131279 4702 22330411 YGL099W LSG1
SGTC_828 2074-0507 139 µM -2.12318837465655 0.0135965952443188 no 3272 0.0168690348737892 4732 X828
SGTC_3189 9110682 49.47 µM -2.13028049828769 0.0133408540992144 no 3273 0.0165742313044207 4690 17122418
SGTC_3280 9140961 49.47 µM -2.14043034675402 0.0129820841453964 no 3274 0.0161600021178265 4713 4901226
SGTC_1862 st057513 3.81 µM -2.15097941050747 0.0126180735619974 no 3275 0.0157389124258993 4720 5393163
SGTC_2424 5537928 59.2 µM -2.16506559507002 0.0121458055187691 no 3276 0.015191331140247 4717 5382802
SGTC_974 1326-0144 138 µM -2.16939409123341 0.0120037957256961 no 3277 0.01502638859369 4724 5411856
SGTC_3006 9075424 71.4286 µM -2.17918006983478 0.011688033636517 no 3278 0.0146591469462654 4690 7465181
SGTC_1887 st057648 70.8 µM -2.18490231679454 0.0115067560644646 no 3279 0.0144480048083313 4727 688672
SGTC_1964 st076914 61 µM -2.1904737847319 0.0113326063811877 no 3280 0.0142449470014434 4745 24208661
SGTC_2621 lithochol-11-enic acid 100 µM -2.20008875489176 0.011037451155893 no 3281 0.0139002992772278 4672 6708711
SGTC_3288 9119690 36.221 µM -2.21370522403589 0.0106309096223941 no 3282 0.0134245316718807 4713 17595618 YKL019W RAM2
SGTC_313 3474-0040 5.03 µM -2.22063986742931 0.0104289231868236 no 3283 0.0131876816375284 4730 1043375 YIL048W NEO1
SGTC_1609 st001574 46.4 µM -2.23417526290732 0.0100442937588349 no 3284 0.0127357717050451 4730 3960012
SGTC_3339 9145883 14.936 µM -2.2413779852086 0.00984470896583492 no 3285 0.0125008006465625 4694 2030670
SGTC_1404 3909-7820 48.3 µM -2.24840252333982 0.00965340641026068 no 3286 0.012275267217804 4730 23741373
SGTC_678 1218-2179 85.9 µM -2.26323262588414 0.00926017114294644 no 3287 0.0118106765102744 4756 6820081 YOR116C RPO31
SGTC_675 1309-0189 238 µM -2.26330163836336 0.00925837447022692 no 3288 0.0118085506857078 4731 4246530
SGTC_2356 9061756 188.97 µM -2.30900117016533 0.00813359540292436 no 3289 0.0104717581544586 4756 20104043
SGTC_330 1488-0319 80.1 µM -2.3119525588638 0.00806526839019424 no 3290 0.0103901489174299 4756 6846614
SGTC_3190 9110366 49.47 µM -2.32734559475445 0.00771702288205551 no 3291 0.00997343944612128 4729 17123768
SGTC_995 3931-2021 34.6 µM -2.3278596578476 0.00770562488773054 no 3292 0.00995977850798109 4723 730143
SGTC_2095 5432005 200 µM -2.32892775298961 0.00768199006110006 no 3293 0.00993144669935764 4742 783734
SGTC_222 nsc-310342 10.666 µM -2.35213230857887 0.00718403548429081 no 3294 0.00933306705031873 4774 432556
SGTC_538 2922-0838 53.3 µM -2.37249380703889 0.00677077144957087 no 3295 0.00883422966320706 4762 777039
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.39171954021523 0.00639998525798169 no 3296 0.00838482565256782 4717 521171
SGTC_392 N-ethylmaleimide 8.33 µM -2.39436831291139 0.00635033557042844 no 3297 0.00832451040645304 4738 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_603 3794-0023 45.9 µM -2.39768568907292 0.00628863436536353 no 3298 0.00824950798623221 4759 3802260
SGTC_2880 9042983 58.44 µM -2.40093729288186 0.00622867217785323 no 3299 0.00817656928492966 4708 6464714
SGTC_1776 st049249 45.9 µM -2.40121787098063 0.00622352189997955 no 3300 0.00817030210288854 4763 1822314
SGTC_2086 5274770 176.623 µM -2.43267098219444 0.00566954302308428 no 3301 0.00749395661276495 4771 689278
SGTC_3027 9089541 49.47 µM -2.43617330229534 0.00561065046200313 no 3302 0.00742178553972773 4745 9943819
SGTC_685 1278-0033 54.9 µM -2.44052916150464 0.00553816379590093 no 3303 0.00733288091401407 4773 3590572
SGTC_615 k087-0205 167 µM -2.44781823390816 0.00541872452755914 no 3304 0.00718620704846494 4758 9642773
SGTC_2433 5607874 27.82 µM -2.44802533096766 0.0054153647298094 no 3305 0.00718207782849836 4740 2252428
SGTC_2721 ifenprodil 61.44 µM -2.44861423654513 0.00540582085518408 no 3306 0.00717034732579323 4740 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1792 st045773 43.6 µM -2.46350735209933 0.00516937942263804 no 3307 0.0068792536858461 4750 2919270
SGTC_1008 4106-0037 6 µM -2.46765947199161 0.00510512278819717 no 3308 0.00679998139587788 4772 2905394
SGTC_1795 st049545 62.3 µM -2.46863753836752 0.00509009046812067 no 3309 0.00678142599897877 4746 5291882
SGTC_1701 st028638 40.4 µM -2.49859966321311 0.00464827540479957 no 3310 0.00623425385690783 4767 3490878
SGTC_885 0865-0106 16.8 µM -2.53321680493194 0.00418067747430374 no 3311 0.00565105122104907 4753 2793380
SGTC_3249 9135183 49.47 µM -2.54946665815176 0.00397605841777829 no 3312 0.00539439134271353 4747 4902779
SGTC_2085 5307070 144.047 µM -2.57461876221873 0.00367699397332664 no 3313 0.00501753143087127 4741 2840351
SGTC_1321 1326-2144 215 µM -2.5769323023898 0.00365052559988965 no 3314 0.00498407355874524 4763 3513030
SGTC_932 2857-0803 154 µM -2.57703913871417 0.00364930746420082 no 3315 0.00498253332875118 4749 674898
SGTC_600 1495-0418 41.6 µM -2.59592179237627 0.00343965287721473 no 3316 0.00471687675998059 4775 5377768
SGTC_2871 9038510 12.99 µM -2.619003362149 0.00319811281482037 no 3317 0.0044093539167713 4746 4945164
SGTC_2069 5228469 200 µM -2.62891573253175 0.0030991522622933 no 3318 0.00428287919037616 4759 2835210
SGTC_2703 st077852 53.4 µM -2.63820994479588 0.00300887676826012 no 3319 0.0041672482736486 4771 6281836
SGTC_5 0352-0601 109.883 µM -2.66061588154816 0.00280090915350013 no 3320 0.0038998941150009 4714 762456
SGTC_527 4476-4215 268 µM -2.66366369212977 0.00277364522917378 no 3321 0.00386473976133733 4772 4418754
SGTC_1753 st043925 64 µM -2.68261366264584 0.00260943740822803 no 3322 0.00365246618893785 4780 670181
SGTC_3127 9126946 49.47 µM -2.69662884933699 0.00249369759091685 no 3323 0.0035022646445123 4752 27243249
SGTC_2969 9091408 28.7 µM -2.74673290590918 0.0021169097389577 no 3324 0.00300960656949692 4738 4286311
SGTC_69 0096-0274 206.684 µM -2.75351586017277 0.00207007872720524 no 3325 0.00294794567029941 4768 6741392
SGTC_169 k015-0017 16.025 µM -2.8163948000045 0.0016786565989439 no 3326 0.00242829726754355 4741 1840002
SGTC_1081 sertraline 6 µM -2.84771001191034 0.0015100147021352 no 3327 0.00220175146543598 4782 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2600 tangeritin 87.95 µM -2.89440197914537 0.00128712555880986 no 3328 0.0018994074767525 4770 68077 A bioactive flavone.
SGTC_1406 3909-7906 11.9 µM -2.94637506660725 0.00107469521938832 no 3329 0.0016076113664308 4792 X1406
SGTC_3222 9128301 49.47 µM -2.95664516115296 0.00103672793816228 no 3330 0.00155502899660769 4767 4911358
SGTC_2742 clothiapine 36.27 µM -2.98687370506365 0.000932003625235851 yes 3331 0.00140923065321486 4798 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1642 st009582 77.7 µM -2.98938732103915 0.000923748578801123 yes 3332 0.00139768765317873 4789 6739311
SGTC_3067 9117431 49.47 µM -3.01693029730758 0.000837592621870463 yes 3333 0.00127674260010713 4792 17150885
SGTC_1647 st011722 22.4 µM -3.0349026776688 0.000785427306302322 yes 3334 0.00120306658014504 4799 2854783
SGTC_3049 9092223 49.47 µM -3.03990938599742 0.000771437451405426 yes 3335 0.00118324668348118 4781 8623917
SGTC_3032 9089427 49.47 µM -3.04672248572133 0.000752768620299782 yes 3336 0.0011567559770437 4773 17173707
SGTC_1007 4101-0031 70 µM -3.05088019351621 0.000741581354502764 yes 3337 0.00114085800068808 4794 1146276
SGTC_942 3253-1115 227 µM -3.07360882306426 0.000683086231421053 yes 3338 0.00105743269553428 4787 46497897
SGTC_2725 haloperidol 53.21 µM -3.07411558510242 0.000681831906391915 yes 3339 0.0010556380838386 4784 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2497 7-hydroxyflavone 100 µM -3.0859251541834 0.000653196080485233 yes 3340 0.00101459946837596 4780 5281894
SGTC_3326 9140064 16.379 µM -3.12482481150924 0.000566536675087749 yes 3341 0.000889554908887515 4784 1868434
SGTC_2593 nobiletin 86.24 µM -3.17770765287244 0.000465708082521258 yes 3342 0.000742221737946027 4780 72344 An anti-infammatory.
SGTC_3329 9141233 27.5565 µM -3.29209096855557 0.000301826553840557 yes 3343 0.000497227196281634 4793 4909101 YNL103W MET4
SGTC_602 3130-1533 38.1 µM -3.30776354953309 0.000284115431578009 yes 3344 0.000470220880649057 4802 720941
SGTC_1700 st030840 7.9285 µM -3.35549274501116 0.000235960368652882 yes 3345 0.000396118672376435 4807 5499307
SGTC_3154 9100113 49.47 µM -3.39783434629263 0.000199726289000349 yes 3346 0.000339607672348596 4791 25237525
SGTC_2782 7736369 71.43 µM -3.64375946560941 7.31166531868843e-05 yes 3347 0.000134342265081547 4793 2950836 YOL077C BRX1
SGTC_2966 9084041 48.03 µM -3.97319044343229 1.72475830766133e-05 yes 3348 3.54581518396368e-05 4799 17741380
SGTC_1655 st012546 55.1 µM -4.0204267157047 1.389183171088e-05 yes 3349 2.90464096071149e-05 4807 720985 YLR208W SEC13
SGTC_344 k064-0035 6.43 µM -4.06638567421664 1.122950640039e-05 yes 3350 2.38739461525877e-05 4801 5088750
SGTC_1755 st041960 45.185 µM -4.51241852516504 1.26976996694775e-06 yes 3351 3.20462790883089e-06 4808 2257073
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -4.71334428294528 4.44251270552742e-07 yes 3352 1.21841979224998e-06 4808 61125 An anti-inflammatory.
SGTC_720 r052-1644 49.9 µM -5.00198972678872 9.12078700382917e-08 yes 3353 2.83708074347953e-07 4809 1422863 YOR257W CDC31
SGTC_723 4182-0001 115 µM -5.09334236939613 5.42556681126389e-08 yes 3354 1.7590278105808e-07 4808 744821 YLR208W SEC13
SGTC_2404 5161160 200 µM -5.45351662043857 6.42076367438355e-09 yes 3355 2.46916639769763e-08 4810 2831543
SGTC_2689 tacrolimus 100 µM -6.11584229519929 8.84641013425042e-11 yes 3356 4.80241382454093e-10 4810 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).