SGTCid condition conc unit YOR093C|YOR093C.score YOR093C|YOR093C.strain.pval YOR093C|YOR093C.strain.significant YOR093C|YOR093C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_310 1273-0058 1.06 µM 5.24165503548002 4.60580443664514e-10 yes 1 7.95713413504057e-08 173 2734232
SGTC_1212 0520-0165 585 µM 4.05257432822387 1.05477712098137e-06 yes 2 2.53285611515114e-05 28 5403258
SGTC_58 0957-0393 9 µM 3.89432400956725 2.56995987842795e-06 yes 3 4.92364771279004e-05 379 6997992
SGTC_2788 5282734 71.43 µM 3.29026606337263 5.71557414767586e-05 yes 4 0.000500463455592782 82 743706
SGTC_2970 9090938 41.86 µM 3.17737951143322 9.68800197048869e-05 yes 5 0.000743062131174086 88 17217104
SGTC_1470 k295-0292 231 µM 3.14073804074022 0.000114578002079752 yes 6 0.000842613471880079 45 5045612
SGTC_1383 3049-0032 20.7 µM 3.09613116972055 0.000140218366608978 yes 7 0.000980318044530415 48 712864
SGTC_545 4218-0007 221 µM 3.05849701942755 0.000165936859224732 yes 8 0.00111225146022095 65 2840508
SGTC_1658 st012944 20 µM 2.99923488999464 0.000215538986532557 yes 9 0.00135329277740178 116 24207260
SGTC_1726 st035556 14.5795 µM 2.99759235889861 0.000217093253665836 yes 10 0.00136060694998483 93 5919439
SGTC_610 4215-0184 155 µM 2.85455317510445 0.000400581823258276 yes 11 0.00215487081338989 61 5605015
SGTC_1691 st019933 84.6 µM 2.84663062063743 0.000414092852642189 yes 12 0.00220922991080379 61 6176082
SGTC_1382 3002-2117 298 µM 2.72445947406569 0.000683747755567054 yes 13 0.00322034170709814 63 1497314
SGTC_2052 5265182 7.135 µM 2.70669479107557 0.00073431899901225 yes 14 0.00339783509637678 97 1239884
SGTC_255 tunicamycin 200.472 nM 2.68422998865135 0.000803203333746775 yes 15 0.00363485390253761 175 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_284 0988-0104 32.6 µM 2.67340204806766 0.000838486922974451 yes 16 0.00375431003013473 64 4666532
SGTC_1251 0490-5699 265 µM 2.61418121513488 0.00105798550596296 no 17 0.00447207916661336 128 3883818
SGTC_1145 3546-0597 10.2 µM 2.61209347324874 0.00106660800935167 no 18 0.00449948230260567 120 875334
SGTC_1172 0370-0043 85 µM 2.58392637532852 0.00118941250840105 no 19 0.00488413220413171 99 376585
SGTC_1732 st034308 51.822 µM 2.53524672435914 0.00143254590733113 no 20 0.00561840763275605 117 830119
SGTC_2522 biochanin a 4.94 µM 2.52992176395694 0.00146172713273733 no 21 0.00570439814270056 85 5280373 A possible chelator.
SGTC_2303 7774051 200 µM 2.52322673885999 0.00149918596837222 no 22 0.00581416984814728 105 2953184
SGTC_205 1486-1330 71.903 µM 2.45391854000883 0.00194173047950617 no 23 0.00706544941177435 72 4118834
SGTC_2101 5377231 179.231 µM 2.45335790932583 0.00194574979504953 no 24 0.00707647207705993 82 2844213
SGTC_987 1497-1013 404 µM 2.40579137347932 0.00231559223061863 no 25 0.0080687387269738 85 1676435
SGTC_2629 bisabolol 100 µM 2.40194824019494 0.0023480900901668 no 26 0.00815400787112541 139 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2791 5663188 71.43 µM 2.39719306639733 0.00238887147836808 no 27 0.00826060800997073 129 54690634
SGTC_1315 1237-0019 3.69 µM 2.37986651222438 0.00254294740948185 no 28 0.00865945528305941 117 825140
SGTC_2802 7925815 54.55 µM 2.34808780032284 0.00284906525699126 no 29 0.00943503628727734 175 1262923
SGTC_1239 0337-0584 35.4 µM 2.33111852188 0.0030257950287658 no 30 0.0098735554468007 210 914301 YML130C ERO1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.27954209307493 0.00362517742261694 no 31 0.0113174303687544 246 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2628 lathosterol 100 µM 2.2772669154284 0.00365391744386702 no 32 0.0113851456749539 160 6710616
SGTC_3012 9080433 71.4286 µM 2.23923447392744 0.00416557585773456 no 33 0.0125703319307903 143 17688859
SGTC_603 3794-0023 45.9 µM 2.22943426100054 0.00430740339331518 no 34 0.0128925123838655 123 3802260
SGTC_297 0986-0032 24 µM 2.19921407329863 0.00477231461185397 no 35 0.0139313520574321 123 2847425
SGTC_334 1502-1024 68.5 µM 2.19875677647387 0.00477968083637326 no 36 0.0139476107182139 164 3296216
SGTC_1924 st058459 75.1 µM 2.17846965439132 0.0051168437825439 no 37 0.0146855445327848 134 688683
SGTC_1648 st011736 69.8 µM 2.17106438435231 0.00524509333634665 no 38 0.0149631529050102 148 2855514
SGTC_67 0335-0847 266 µM 2.1657671988978 0.00533858012256463 no 39 0.0151644905218187 335 4552207 YOR254C SEC63
SGTC_590 k048-0076 22.4 µM 2.15716915008219 0.00549347862106976 no 40 0.0154962436217096 156 6832814
SGTC_3190 9110366 49.47 µM 2.08725293139317 0.00690863546827259 no 41 0.0184326385323864 142 17123768
SGTC_352 k048-0007 5.11 µM 2.07666568625124 0.00714889996465827 no 42 0.0189162128572475 259 6811911
SGTC_846 0335-0850 148 µM 2.07172214829739 0.00726359040089358 no 43 0.0191456803016579 179 6819598
SGTC_3242 9133940 49.47 µM 2.05623200406352 0.00763353692140344 no 44 0.0198800794046601 177 17248444
SGTC_1901 st060216 58.6 µM 2.04082683272056 0.00801780675320694 no 45 0.0206340212360786 210 688792
SGTC_996 3970-0799 1.8 µM 2.03703349378089 0.00811499893097852 no 46 0.0208233428351491 353 6615648 YGL040C HEM2
SGTC_1697 st025554 27.742 µM 2.03411584819533 0.00819045719640719 no 47 0.0209699582194962 186 1269519
SGTC_2584 androsterone 48.74 µM 2.02899063136986 0.00832450262804773 no 48 0.0212296222790653 385 2754130 A steroid.
SGTC_188 3229-0966 278.469 µM 2.023756263606 0.00846338736633937 no 49 0.0214976181795024 258 5722370
SGTC_1815 st051655 58.2 µM 2.01916105262591 0.00858698527821457 no 50 0.0217352414631544 148 5984156
SGTC_3010 9080089 71.4286 µM 2.01465552246776 0.00870970555761426 no 51 0.021970377772748 206 17027233
SGTC_886 0866-0150 153 µM 2.00303381305446 0.0090333795302389 no 52 0.0225868296297526 244 271463
SGTC_2965 9082772 38.63 µM 1.99688461797781 0.00920886428595665 no 53 0.022918859266294 244 16459634
SGTC_2103 5378138 10 µM 1.99634696201723 0.00922434874028364 no 54 0.0229480848088933 221 244142
SGTC_1736 st036774 51 µM 1.99475165687708 0.00927042761435274 no 55 0.0230349861588871 226 1272247
SGTC_1428 4049-0204 61.7 µM 1.99230015542161 0.00934162950327898 no 56 0.0231690673334831 209 X1428
SGTC_415 dibenzyl ketone 100 µM 1.97792806937222 0.00976875600312363 no 57 0.0239684109338262 205 7593
SGTC_1672 st016598 6.51 µM 1.9650245504764 0.0101666731623195 no 58 0.0247056980634152 285 4665860 YNL267W PIK1
SGTC_2219 9098279 200 µM 1.96350363874015 0.0102144938767902 no 59 0.0247938410449495 190 902349
SGTC_1948 st076329 66.6 µM 1.9377733604859 0.0110537562593874 no 60 0.0263254396067872 224 24208413
SGTC_916 4466-0038 42 nM 1.92088484880111 0.0116366766690243 no 61 0.0273731131475215 359 5722064 YGL116W CDC20
SGTC_1767 st044992 70.3 µM 1.91330237231796 0.0119069562977041 no 62 0.0278546771077631 270 9600693
SGTC_2785 7756463 72.73 µM 1.90815725322323 0.0120934419681922 no 63 0.0281854473419173 247 2201551
SGTC_1395 3486-0190 4.35 µM 1.90144382127556 0.0123405750992506 no 64 0.0286219521655516 241 6748079
SGTC_155 k072-0202 43.6 µM 1.88375116287786 0.0130129339815983 no 65 0.0297993211584448 218 5857737
SGTC_1811 st050069 61.5 µM 1.87677376701524 0.0132866699697491 no 66 0.0302745536697847 189 3877702
SGTC_2432 5630864 12.22 µM 1.86960223842031 0.0135731915245681 no 67 0.0307695371062609 272 5714970
SGTC_1830 st055982 50.3 µM 1.86639351297891 0.0137031056479845 no 68 0.0309931650222668 264 455313 An antimicrobial agent.
SGTC_1641 st009299 47.1 µM 1.8566069756279 0.0141059872744387 no 69 0.0316835453913372 181 4046054
SGTC_57 miconazole 162.5 nM 1.85655056875516 0.0141083386449696 no 70 0.0316875610850248 250 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1353 1498-1206 8.11 µM 1.85343551402242 0.014238717905011 no 71 0.0319099805016865 330 6756808
SGTC_3297 9117502 71.43 µM 1.84791892319776 0.0144721598069436 no 72 0.0323070362926782 207 7453720
SGTC_1385 3091-4834 14.1 µM 1.82496136220008 0.0154793573383648 no 73 0.0340034300939097 245 4072814
SGTC_1451 4152-0210 104 µM 1.82075249695763 0.0156703933285246 no 74 0.034322244087379 299 659563
SGTC_1751 st044839 27.194 µM 1.81970713883399 0.015718153427401 no 75 0.0344018077974194 222 5291326
SGTC_360 0957-0399 1.01 µM 1.81831945048151 0.0157817466980369 no 76 0.034507660820257 303 6752301 YPR165W RHO1
SGTC_1908 st060353 56.5 µM 1.81811464782086 0.0157911508040047 no 77 0.0345233058258784 332 4227716
SGTC_2282 7944268 200 µM 1.81740829044796 0.0158236221263276 no 78 0.0345773096271876 310 2970414
SGTC_2363 9053361 176 µM 1.8134792355258 0.0160052881902584 no 79 0.034878969192205 307 6469797 YMR079W SEC14
SGTC_189 3970-0742 2.116 µM 1.81324480989221 0.0160161835166598 no 80 0.034897035684522 218 2891807
SGTC_2369 9071472 200 µM 1.80975723060444 0.0161790269606138 no 81 0.0351667215473449 286 17296037
SGTC_3086 9117350 49.47 µM 1.80974735867337 0.0161794899106389 no 82 0.0351674873393099 168 2679265
SGTC_1370 2001-0092 44.6 µM 1.80936278159824 0.0161975337144101 no 83 0.0351973306563259 335 790957
SGTC_2588 indole-3-carbinol 100 µM 1.8020105624227 0.0165458189140795 no 84 0.0357718718824042 343 3712 Induces cell cycle arrest.
SGTC_3322 9139058 2.11 µM 1.79239352932414 0.0170110516423538 no 85 0.036534975289908 288 4908926 YPR165W RHO1
SGTC_2009 4012297 12.05 µM 1.7909842173783 0.0170801591220613 no 86 0.0366479138576805 316 45595307
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.7876100687994 0.0172465905852459 no 87 0.0369194699383252 265 279621
SGTC_2986 9022445 71.43 µM 1.76985481842319 0.018145380637218 no 88 0.0383756645527819 294 6459286
SGTC_988 1497-1057 103 µM 1.76848373867147 0.0182164171316652 no 89 0.0384900341761733 310 3533044
SGTC_1269 0831-0796 3.05 µM 1.76691851224779 0.0182978020495691 no 90 0.0386209381226692 291 927758
SGTC_3018 9082602 49.47 µM 1.7622953056195 0.0185399996226156 no 91 0.0390097083121577 309 17332089
SGTC_1058 3448-5425 97.3 µM 1.76083555394515 0.0186170369268426 no 92 0.0391331201312997 292 7279705
SGTC_1270 0831-1170 17.3 µM 1.75209156598662 0.0190842215779313 no 93 0.0398790321407941 307 6764716
SGTC_2148 5546263 113.568 µM 1.74083431248261 0.0197003340496278 no 94 0.0408563127721248 304 792097
SGTC_2275 7947463 200 µM 1.73501828148979 0.020025208981661 no 95 0.0413687835832994 279 1225414
SGTC_1283 0922-0125 16.4 µM 1.73353912912266 0.0201085534303952 no 96 0.041499944483294 330 3360884
SGTC_2879 9041815 71.43 µM 1.72324463310518 0.0206967951109075 no 97 0.0424221477471817 193 4942971
SGTC_376 3970-0862 59.1 µM 1.71990820400863 0.0208905433404157 no 98 0.0427245645103325 319 3135186
SGTC_874 0599-0792 117 µM 1.71214494477181 0.0213473094750625 no 99 0.0434349802007071 378 765305
SGTC_2704 st078022 71.1 µM 1.71010324690479 0.0214688296855667 no 100 0.0436233912473506 310 54697681
SGTC_746 1095-0025 46.6 µM 1.70125409438931 0.0220023049945954 no 101 0.0444476420084025 324 6749286
SGTC_1354 1498-1681 81 µM 1.70080170049815 0.0220298758294699 no 102 0.0444901149315287 337 5754243
SGTC_1558 st069300 45.6 µM 1.69891147676301 0.0221453899321736 no 103 0.0446679321244615 224 24208000
SGTC_3002 9075603 71.4286 µM 1.68924707855842 0.0227440122539629 no 104 0.0455860452088151 328 20105405
SGTC_465 cgp-37157 41 µM 1.68469115153706 0.0230309065502126 no 105 0.0460240872857975 207 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3287 9117173 37.0625 µM 1.66692298599032 0.0241790839662127 no 106 0.0477648598057236 237 2789709
SGTC_669 0108-0021 26.2 µM 1.66564159110663 0.0242637144048673 no 107 0.0478924109954683 485 17201
SGTC_1030 k029-0042 36.7 µM 1.66335116847549 0.0244156063635443 no 108 0.0481210808749668 382 6080581
SGTC_3064 1327-0027 10 µM 1.66292632533708 0.024443867897221 no 109 0.0481635920187852 182 16000455 YPR107C YTH1
SGTC_2983 9022671 12.99 µM 1.66024047725381 0.0246231728986504 no 110 0.0484330423606409 316 6405161
SGTC_1320 1313-0481 95.3 µM 1.657464682403 0.0248096410618027 no 111 0.0487127817748473 329 6813365 YLR208W SEC13
SGTC_890 0929-0006 47.2 µM 1.65336778672885 0.0250870191782399 no 112 0.0491280173633857 304 1378169
SGTC_3048 9093155 49.47 µM 1.65161700504143 0.0252063452227244 no 113 0.0493063256098542 271 25236002
SGTC_2421 5690543 90.72 µM 1.65035090514531 0.0252929333916386 no 114 0.0494355931328399 340 3397993
SGTC_196 k015-0023 18.111 µM 1.64577684488969 0.0256078310427999 no 115 0.0499048555997038 366 5211998
SGTC_152 4469-0003 551.229 µM 1.64437357813891 0.0257050933316605 no 116 0.0500495296917904 327 697280
SGTC_734 2023-0417 80 µM 1.64077386621417 0.0259560090219296 no 117 0.0504221825337081 364 3935732
SGTC_3153 9100258 49.47 µM 1.63770251712886 0.0261717124067667 no 118 0.0507418826407599 355 25236848
SGTC_687 k029-0044 34.9 µM 1.6357844620759 0.0263071778000804 no 119 0.0509423525300021 351 5829338
SGTC_3210 9128157 49.47 µM 1.62689769182668 0.0269424904947179 no 120 0.0518794141467153 382 17590849
SGTC_109 0132-0036 33.701 µM 1.6260071735036 0.0270068535257915 no 121 0.0519740646733812 232 67274 A color developer.
SGTC_1655 st012546 55.1 µM 1.62380051527579 0.0271668949443413 no 122 0.0522091950334033 327 720985 YLR208W SEC13
SGTC_2692 st077426 47.7 µM 1.62325827609727 0.0272063425906533 no 123 0.0522671024129857 367 25238571
SGTC_1590 st077108 57.8 µM 1.61472931794154 0.0278331332467002 no 124 0.0531846628206552 317 5489485
SGTC_1350 1495-0454 146 µM 1.61095681125692 0.0281141867116749 no 125 0.0535945680575224 422 1069057
SGTC_1271 0832-2808 169 µM 1.61094828262715 0.0281148247656356 no 126 0.05359549757109 369 3663794
SGTC_1610 st001799 48.1 µM 1.61070063836089 0.0281333570805145 no 127 0.0536224932565592 290 621897
SGTC_1651 st011928 86.1 µM 1.60192785318587 0.028796454509933 no 128 0.0545857822086483 337 720198
SGTC_354 2783-3500 4.88 µM 1.59977897937871 0.0289608451643043 no 129 0.0548238118264608 397 6740761
SGTC_1036 k216-0215 33.5 µM 1.59310676469804 0.0294762528746771 no 130 0.0555681210246262 449 622330
SGTC_2415 st077333 57.7 µM 1.59236382339414 0.0295341110410741 no 131 0.0556514899536689 449 2766255
SGTC_2309 7664088 163.95 µM 1.59087022137626 0.0296507138207271 no 132 0.0558193927434349 422 704922
SGTC_670 4204-0025 119 µM 1.58785588565324 0.029887201162911 no 133 0.0561594654193511 408 719039
SGTC_2341 7987486 176.74 µM 1.58622492815535 0.0300158075444553 no 134 0.0563441474423945 412 1258686
SGTC_3006 9075424 71.4286 µM 1.58472078139137 0.0301348209151997 no 135 0.0565148940456322 368 7465181
SGTC_2050 5263056 171 µM 1.57850616619257 0.0306306976412216 no 136 0.0572246863370361 447 763468 YGL055W OLE1
SGTC_1725 st036284 20.55 µM 1.57803646303288 0.0306684492872376 no 137 0.0572786166239415 433 707914
SGTC_3069 9117009 49.47 µM 1.57720649566953 0.0307352507842745 no 138 0.0573740094256884 255 41904981
SGTC_1578 josamycin 24.2 µM 1.5734949887098 0.0310354540638509 no 139 0.0578021238894584 342 5282165 A P450 substrate.
SGTC_1981 st071826 47 µM 1.56955843970189 0.0313565069488619 no 140 0.0582589368549247 339 11838600
SGTC_816 0325-0417 81.3 µM 1.56182256496939 0.0319954235525098 no 141 0.0591648972177516 353 68101
SGTC_216 k038-0035 28.382 µM 1.55803410342654 0.0323122176982912 no 142 0.0596125820164061 346 4444231 YPR107C YTH1
SGTC_3230 9131665 49.47 µM 1.55651547302466 0.032439931460057 no 143 0.0597927831033401 219 15943720
SGTC_65 0798-0905 34.986 µM 1.55176982906388 0.0328417172317237 no 144 0.0603586537544189 520 3602145
SGTC_1090 efavirenz 20.7 µM 1.54984107372751 0.0330061818311215 no 145 0.0605898329344466 383 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2390 9097792 176.6 µM 1.54123977808402 0.0337478950432292 no 146 0.0616292198048708 363 4497149
SGTC_1379 2144-0755 36.5 µM 1.53763371427787 0.0340629096743948 no 147 0.0620690996275445 435 5392327
SGTC_1708 st033234 31.827 µM 1.52308062514027 0.0353588837672699 no 148 0.0638692677443458 435 674664
SGTC_3039 9090270 49.47 µM 1.52283600206654 0.0353810086653428 no 149 0.06389987016184 361 17173750
SGTC_2915 7971052 15.16 µM 1.51093114108493 0.0364715390100175 no 150 0.0654029978560931 276 5741558
SGTC_692 k241-0027 77.8 µM 1.50161132457568 0.0373443341968224 no 151 0.0665987584774509 398 3600480
SGTC_3270 9137563 49.47 µM 1.49633141956364 0.0378463177640532 no 152 0.0672836556503295 356 17015724
SGTC_3226 9131256 49.47 µM 1.49293809093991 0.0381718332980204 no 153 0.0677266965750082 264 17178073
SGTC_1906 st060206 94.7 µM 1.4922894872628 0.0382343117937709 no 154 0.0678116357481112 450 5133468
SGTC_2150 5556613 200 µM 1.49206179655633 0.0382562644794027 no 155 0.0678414729366704 454 743190
SGTC_844 0330-0132 15.3 µM 1.49120442438606 0.0383390198206072 no 156 0.067953916218337 417 2828079
SGTC_1029 k015-0030 64.7 µM 1.48595844972193 0.0388485558903089 no 157 0.0686450558287599 423 2208316
SGTC_1493 4348-0038 111 µM 1.48161283585802 0.0392748055920734 no 158 0.069221670831198 464 800424
SGTC_1010 4112-3296 15.2 µM 1.47874155731982 0.0395585241070955 no 159 0.06960470044334 463 704384
SGTC_967 1306-0166 352 µM 1.47632227281631 0.039798871909313 no 160 0.06992869884772 446 4437607
SGTC_2594 a-mangostin 100 µM 1.47107907428941 0.0403238411499198 no 161 0.0706348667057013 474 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1497 4476-2978 41.3 µM 1.46669032036062 0.0407675713992934 no 162 0.0712301586164294 480 1528379
SGTC_1178 0988-0033 191 µM 1.46503667355084 0.0409357896490263 no 163 0.0714554561764796 478 5392207
SGTC_2158 5657123 3.6195 µM 1.46412724904567 0.0410285411203833 no 164 0.0715795916295799 409 2858827
SGTC_2794 7785382 27.27 µM 1.4566589665925 0.0417966883558113 no 165 0.0726052709362914 529 2205081
SGTC_154 3389-1638 511.116 µM 1.4552691114838 0.0419409187008428 no 166 0.0727973871940203 388 5238686
SGTC_1644 st010134 20.9 µM 1.45373264664971 0.042100831929398 no 167 0.0730102216512031 417 3818134
SGTC_381 3461-2219 42.7 µM 1.45316083947258 0.0421604707168467 no 168 0.0730895511140462 460 2883159
SGTC_1974 st069448 26.9 µM 1.45273887879025 0.0422045245244507 no 169 0.0731481339626803 417 6323587 YNR016C ACC1
SGTC_2591 skatole 100 µM 1.45259049900742 0.0422200246140976 no 170 0.0731687427840471 433 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_325 2810-4341 181 µM 1.44561940913727 0.0429534475641134 no 171 0.0741419898456853 420 774970
SGTC_1332 1480-0653 17.5 µM 1.43514106660203 0.0440751980087108 no 172 0.0756234516113063 483 5749438
SGTC_1319 1306-0155 43.7 µM 1.42977652598824 0.0446585705366289 no 173 0.0763905841988293 517 3122360
SGTC_3060 1327-0027 12.5 µM 1.42547790049145 0.0451305036126039 no 174 0.077009551926289 426 16000455 YPR107C YTH1
SGTC_790 1575-0012 79.1 µM 1.42540375216784 0.0451386792057644 no 175 0.0770202620362613 473 378741 YLR208W SEC13
SGTC_1808 st050063 61.5 µM 1.42208784001904 0.0455055116181596 no 176 0.0775003761987575 443 4011993
SGTC_2126 5251174 33.877 µM 1.42117240986574 0.0456072048937907 no 177 0.077633321724585 567 790722
SGTC_1177 0983-0204 23.6 µM 1.41772078397851 0.0459922832541059 no 178 0.078136149803612 498 766818
SGTC_1678 st019265 80.2 µM 1.41671021178386 0.0461055200890854 no 179 0.0782838350956737 503 5367020
SGTC_458 nppb 133 µM 1.41419411145508 0.0463884276690779 no 180 0.0786524582329342 419 4549 A chloride channel blocker.
SGTC_989 1501-0895 10.3 µM 1.41360652413602 0.046454695668115 no 181 0.0787387323202369 440 2830112
SGTC_2046 4110841 106 µM 1.40549060859179 0.0473778028796139 no 182 0.0799377200118969 466 44119630 YMR134W ERG29
SGTC_110 0850-0284 111.64 µM 1.40099178934244 0.0478957979871258 no 183 0.0806082642008891 342 3906265
SGTC_1988 st071872 53.4 µM 1.39829550005406 0.0482084159066554 no 184 0.0810121743137577 440 16414116
SGTC_2803 7707263 71.43 µM 1.39814453843591 0.0482259671112042 no 185 0.0810348337749338 448 2199229
SGTC_73 0327-0325 16.231 µM 1.39783117521135 0.048262415883752 no 186 0.0810818851187166 546 53298
SGTC_1794 st048918 76.9 µM 1.39433170041824 0.0486709554827121 no 187 0.0816087311987626 382 672303
SGTC_366 0181-0206 4.31 µM 1.3912748607305 0.0490300783372655 no 188 0.0820710470060093 517 274874
SGTC_326 k292-0812 17.5 µM 1.38790975980631 0.0494278607165547 no 189 0.0825822627729743 454 3579357
SGTC_254 nsc-64875 3.808 µM 1.38245068836329 0.0500786426867977 no 190 0.0834166807680133 475 56993
SGTC_656 4090-1979 187 µM 1.3817229817261 0.0501659070896511 no 191 0.0835283875559024 536 22330961
SGTC_1262 0737-0114 49.6 µM 1.38154735114978 0.050186986331206 no 192 0.0835553646028734 561 765919
SGTC_2693 st077581 40.7 µM 1.37996990065603 0.050376629122528 no 193 0.0837979562536883 592 25238761
SGTC_1828 st055811 49 µM 1.37618677456001 0.05083376782822 no 194 0.0843819077978291 425 5877589
SGTC_3266 9136860 49.47 µM 1.37306023105508 0.0512140550743432 no 195 0.0848668114925823 516 4871271 YPR165W RHO1
SGTC_1211 1056-0033 32.3 µM 1.37212161714281 0.051328661128095 no 196 0.0850127904964734 508 6741922
SGTC_2347 9049783 174.81 µM 1.37208847660572 0.051332711359136 no 197 0.0850179481542422 535 6467988 YPL169C MEX67
SGTC_1142 3253-1408 9.78 µM 1.36847386500641 0.051775994941869 no 198 0.0855818986016719 482 256655
SGTC_2257 7960413 200 µM 1.3639303425971 0.0523375068037861 no 199 0.0862947450015017 569 2974689 YIL048W NEO1
SGTC_1999 st074831 12.5 µM 1.36313208220467 0.0524366574691519 no 200 0.0864204436868056 523 17112523
SGTC_548 1436-0017 110 µM 1.35924893307847 0.0529211060198558 no 201 0.0870338600560825 598 9677137
SGTC_1734 st037168 69.4 µM 1.35615055879296 0.0533101893952753 no 202 0.0875256345830646 502 708907
SGTC_1941 st076221 61.8 µM 1.35427494192944 0.0535468225322593 no 203 0.0878243387478708 575 2828568
SGTC_2491 paeonol 100 µM 1.35111184691469 0.0539477718050547 no 204 0.0883298035293414 442 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1496 4469-0713 57.4 µM 1.34696141889589 0.0544774751773433 no 205 0.0889963293514956 506 746691
SGTC_1280 0880-0253 10.1 µM 1.34552464695968 0.0546618004832604 no 206 0.0892279337066185 532 6836607
SGTC_163 TUB2.036 7.546 µM 1.34510861874681 0.0547152652369209 no 207 0.0892950801615755 698 15992207 YJR013W GPI14
SGTC_182 3448-4371 550.524 µM 1.34135162642119 0.055199959507245 no 208 0.0899031576741206 544 3491403
SGTC_2691 st077356 60.2 µM 1.34119058031365 0.0552208118296428 no 209 0.0899292919600011 521 2839272
SGTC_2639 lactacystin 53 µM 1.33758740799478 0.0556889810307095 no 210 0.0905154857259642 556 3870 A proteasome inhibitor.
SGTC_2519 cryptotanshinone 88.04 µM 1.33438109354249 0.0561082143545038 no 211 0.0910394965049199 496 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_891 0929-0073 133 µM 1.33246621537783 0.0563597738704691 no 212 0.0913535180324365 516 5603632
SGTC_84 0443-0269 128.823 µM 1.33010413076288 0.0566713071034779 no 213 0.0917419823659139 530 6150058
SGTC_206 4546-0025 72.014 µM 1.3277710247964 0.0569803485368616 no 214 0.0921268809145067 608 6620745 YIL048W NEO1
SGTC_2946 9065502 71.43 µM 1.32286159708462 0.0576349804099948 no 215 0.0929407041791395 360 16489101
SGTC_2358 9037157 4 µM 1.32124692174794 0.0578515719457523 no 216 0.0932095228324885 536 2388925
SGTC_3289 9119912 71.43 µM 1.31906823468379 0.0581448332171556 no 217 0.0935731508111102 518 17014829
SGTC_718 1130-0073 349 µM 1.31778563164648 0.0583180229212373 no 218 0.093787709571734 560 6740020
SGTC_1079 idarubicin 2.36 µM 1.31591489229681 0.0585713547713217 no 219 0.0941013048630655 506 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_938 3126-1755 342 µM 1.31416669374133 0.058808872577049 no 220 0.0943950570633825 565 1777771
SGTC_2405 ticlatone 3.52 µM 1.31310968759772 0.0589528482644956 no 221 0.094572994970096 513 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2997 9067075 71.4286 µM 1.31176184018892 0.0591368406711118 no 222 0.0948002520281579 578 27209819
SGTC_1343 1487-0095 224 µM 1.30865643380249 0.0595624686905329 no 223 0.0953253777113636 509 4560101 YGL055W OLE1
SGTC_180 1486-1293 102.781 µM 1.30629394796917 0.0598878768573039 no 224 0.0957263072137281 541 4140536
SGTC_2102 5377816 72.7585 µM 1.30588447491422 0.0599444188931441 no 225 0.0957959234666354 567 1379702
SGTC_3327 9140648 26.9345 µM 1.30524162444739 0.0600332711524485 no 226 0.095905292324046 522 8029710
SGTC_1968 st069590 43.6 µM 1.3007733498111 0.0606537110455066 no 227 0.0966680233269635 528 6384066
SGTC_2474 5321570 43.32 µM 1.29996376174334 0.0607666607822416 no 228 0.096806694830912 521 2841384
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.29127662827201 0.0619890232771531 no 229 0.0983038859651725 574 5393153
SGTC_81 0411-0046 9.971 µM 1.29008561982081 0.062158094758644 no 230 0.0985104660773045 509 12925265
SGTC_1973 st070275 50.2 µM 1.28777820977417 0.0624866701355318 no 231 0.0989115897761229 504 17118334
SGTC_2863 9028737 58.44 µM 1.2857312278284 0.0627792926480413 no 232 0.0992684394080175 499 6460917
SGTC_2967 9089538 49.85 µM 1.28509657417115 0.0628702349197351 no 233 0.09937926929297 589 728216
SGTC_2243 6634756 200 µM 1.28501905638349 0.062881349809753 no 234 0.0993928124594455 507 885676
SGTC_2870 9038528 12.99 µM 1.28121128873511 0.063429213602995 no 235 0.100059731034185 496 6463316
SGTC_2748 diazoxide 86.69 µM 1.27766153957542 0.0639432930539311 no 236 0.100684395876129 497 3019 A potassium channel activatior.
SGTC_2299 7976368 114.88 µM 1.27546333941677 0.0642632601567625 no 237 0.101072646068458 546 2979718
SGTC_2351 9026858 72.31 µM 1.26765373259316 0.065410087368264 no 238 0.102460817131889 522 1409300
SGTC_1831 st055328 12 µM 1.26645874336817 0.0655869611815821 no 239 0.102674445561422 584 1103068
SGTC_1423 4048-0112 5.59 µM 1.26645443986186 0.0655875988255166 no 240 0.102675215484574 571 X1423
SGTC_2746 daunorubicin 9.88 µM 1.25617402595263 0.067124599057937 no 241 0.104526440877963 409 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1673 st016611 27.3 µM 1.25509374098385 0.0672877138099923 no 242 0.104722366168428 586 5226799
SGTC_2606 farnesol 9.78 µM 1.25487654329175 0.0673205459640951 no 243 0.104761790200315 585 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2220 6782180 200 µM 1.25187595216223 0.0677753912215684 no 244 0.105307534343241 491 833803
SGTC_739 1486-1183 203 µM 1.25096717329828 0.0679136159580027 no 245 0.10547322711699 599 4346692
SGTC_1215 3852-0577 11.2 µM 1.25016464297608 0.0680358612650457 no 246 0.105619704872236 640 2884876
SGTC_1246 0422-0085 105 µM 1.24758602165485 0.0684297994182625 no 247 0.106091350062564 638 264295
SGTC_11 0438-0307 1.3 µM 1.2453544406214 0.0687721383859233 no 248 0.106500746167858 561 4011476
SGTC_1397 3532-0190 20.1 µM 1.24292579353597 0.0691462075533997 no 249 0.106947589887193 496 5322280
SGTC_828 2074-0507 139 µM 1.2334100567296 0.0706269765138549 no 250 0.108711407409067 622 X828
SGTC_3133 9127736 49.47 µM 1.22551323408454 0.0718742264010117 no 251 0.110190953446124 617 27243420
SGTC_959 1222-0044 107 µM 1.22491654107623 0.0719691521094469 no 252 0.11030333372543 597 6083612
SGTC_2263 7948595 193.29 µM 1.22139338645238 0.0725315984390202 no 253 0.110968555019204 531 2971371
SGTC_2642 cholecalciferol 100 µM 1.22074649684991 0.0726352346014293 no 254 0.111091008501832 567 9821465 A vitamin D precursor, similar to steriods.
SGTC_2619 obliquin 87.91 µM 1.21551200251216 0.073478012526973 no 255 0.112085436912797 695 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3262 9137218 49.47 µM 1.21021992253262 0.0743376433628002 no 256 0.11309725768678 444 17650664
SGTC_1602 st001878 87.6 µM 1.20871769359232 0.0745830552231905 no 257 0.113385660844894 600 595405 YLR310C CDC25
SGTC_3042 9091578 49.47 µM 1.20860316674584 0.0746017902579732 no 258 0.113407669608327 570 25236497
SGTC_2930 9013230 14.89 µM 1.20823415062919 0.0746621807094114 no 259 0.113478604608112 652 2995857
SGTC_1903 st060211 78.3 µM 1.20813063185763 0.0746791285258621 no 260 0.11349850943154 656 688960
SGTC_283 0987-0079 11.7 µM 1.20691253208835 0.0748787731411662 no 261 0.113732915434424 646 411556
SGTC_2616 abietic acid 100 µM 1.20182060347382 0.0757177426748144 no 262 0.114716520518448 652 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1855 st056195 39.6 µM 1.20038621765362 0.0759553665492861 no 263 0.114994689517715 605 4028379
SGTC_207 4185-0010 4.486 µM 1.1970520837859 0.0765099008039637 no 264 0.115643127315967 707 3761753
SGTC_1008 4106-0037 6 µM 1.19603402796837 0.0766798364715448 no 265 0.115841640173074 589 2905394
SGTC_2905 7799065 20.05 µM 1.19577719533646 0.0767227527327701 no 266 0.115891758712447 594 1296806
SGTC_1089 terbinafine 2.25 µM 1.19149039198987 0.077441769021242 no 267 0.116730563132791 610 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1717 st033143 58.0435 µM 1.18969943605651 0.0777436733757187 no 268 0.117082273562868 683 674616
SGTC_365 0121-0052 13.6 µM 1.18662527158127 0.0782639719493264 no 269 0.117687731545268 696 3101739
SGTC_1475 4092-1048 11.7 µM 1.18613729708969 0.0783468033277014 no 270 0.117784041754501 678 2881759
SGTC_2245 6637752 200 µM 1.17912357057971 0.0795447057848814 no 271 0.119174487076326 549 681890
SGTC_1779 st039427 55 µM 1.17848336856143 0.0796547349796803 no 272 0.11930197943663 731 1124498
SGTC_978 1416-0512 87.4 µM 1.17660820248676 0.0799776755070084 no 273 0.119675961184064 686 6814003
SGTC_2976 9009005 19.48 µM 1.17337923077816 0.0805360866596725 no 274 0.120321881098181 636 2993148
SGTC_699 0375-0592 111 µM 1.17218713805478 0.0807429872114598 no 275 0.120560965568758 671 762578
SGTC_2493 resveratrol 26.09 µM 1.17035259958154 0.0810621749172 no 276 0.120929551243965 587 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3096 9117468 49.47 µM 1.16992388632018 0.0811369029730634 no 277 0.12101580020612 527 41316311
SGTC_2820 7989630 71.43 µM 1.16979538089134 0.0811593125919859 no 278 0.121041661485284 523 2984098
SGTC_945 3381-0768 11.3 µM 1.16763731204802 0.0815363489040191 no 279 0.121476546488318 688 1126236 YIL048W NEO1
SGTC_2918 7977171 22.06 µM 1.16739709835172 0.0815783982087715 no 280 0.121525021196632 627 2236483
SGTC_80 0159-0065 512.242 µM 1.16459874245279 0.0820694546173402 no 281 0.122090726543272 538 1548079
SGTC_1913 st060213 96.1 µM 1.1636778499545 0.0822315391764935 no 282 0.122277294546209 690 688959
SGTC_1445 4239-0156 97.7 µM 1.16356215707527 0.0822519190983992 no 283 0.122300747461296 754 4008346
SGTC_1143 3454-2408 5.08 µM 1.16326796244876 0.0823037601969209 no 284 0.122360399940527 608 X1143
SGTC_164 4100-3994 89.624 µM 1.16309849202131 0.0823336343610301 no 285 0.122394771941216 724 4615967
SGTC_958 1222-0007 33 µM 1.16200659154807 0.082526309863812 no 286 0.122616393733014 701 7312461
SGTC_2382 9035899 200 µM 1.1596985821444 0.0829346952580016 no 287 0.123085773830092 673 6462679
SGTC_1561 5-methoxyflavone 52.9 µM 1.15963110697593 0.0829466573265367 no 288 0.123099515184372 597 94525
SGTC_417 st075190 100 µM 1.1577783843385 0.0832756172192386 no 289 0.123477243314389 683 222757
SGTC_1872 amphotericin b 148 nM 1.15645257159924 0.0835116231041321 no 290 0.123748044336498 662 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_796 1234-0020 70.7 µM 1.15520769104236 0.0837336795933887 no 291 0.124002692975391 638 46495034
SGTC_2138 5575593 77.673 µM 1.15314758806554 0.0841021258836452 no 292 0.124424905906549 615 762213
SGTC_2717 st081029 62.2815 µM 1.14941132329788 0.084773454453438 no 293 0.125193206557917 648 5292846
SGTC_382 3229-0966 23.2 µM 1.149343266387 0.0847857200108001 no 294 0.125207231981653 704 5722370
SGTC_1926 methyl fluorone black 53.6 µM 1.14837870525604 0.0849597011545499 no 295 0.125406130335221 601 72721 Reacts with homocysteine.
SGTC_2483 5729050 27.16 µM 1.14572588724875 0.0854395789082689 no 296 0.125954294507844 765 2865180
SGTC_2896 9052656 71.43 µM 1.14337266493653 0.0858669583465119 no 297 0.126441948382139 757 6469436
SGTC_2753 fluvastatin 17.09 µM 1.14137392009762 0.0862312144482279 no 298 0.126857176408244 680 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1739 st037196 92.5 µM 1.13824525368967 0.0868037088202581 no 299 0.12750904354724 727 612214
SGTC_2831 7999036 19.48 µM 1.13626640663283 0.0871672685482758 no 300 0.127922542822849 711 2988270
SGTC_1365 1672-3266 55.4 µM 1.13349076825344 0.0876791315021692 no 301 0.128504107913497 722 6415873
SGTC_2605 digitonin 300 nM 1.13313414674069 0.0877450592728532 no 302 0.128578961792721 775 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3095 9117207 49.47 µM 1.1290337865322 0.0885057419663389 no 303 0.129441790595835 636 17015229
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.11856313385331 0.0904704914819977 no 304 0.131663279256927 512 6708630 An antioxidant.
SGTC_3073 9114972 49.47 µM 1.11685113130317 0.0907947942368919 no 305 0.132028991179395 635 41905075
SGTC_1814 st052110 31.539 µM 1.11678679249032 0.0908069986638769 no 306 0.132042748653399 659 674163
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.11677409852366 0.0908094067257069 no 307 0.132045463102437 685 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_549 1661-1316 519 µM 1.11652268205562 0.0908571105172126 no 308 0.1320992333585 711 2857282
SGTC_1758 st042942 75.2445 µM 1.11515881343398 0.0911162151682143 no 309 0.132391186032545 708 669317
SGTC_1825 st052143 62.6 µM 1.11213681593129 0.0916922789900395 no 310 0.133039664725343 656 674173
SGTC_683 panaxydol 45 µM 1.11045762808414 0.0920135356815752 no 311 0.133400938578872 729 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_344 k064-0035 6.43 µM 1.10630175059148 0.0928122071488185 no 312 0.134297967171983 670 5088750
SGTC_3183 9108214 49.47 µM 1.10533585557011 0.0929985636601165 no 313 0.134507043421909 588 4974831
SGTC_2006 4011487 200 µM 1.10317129972282 0.0934171899335677 no 314 0.134976391186395 731 45595294
SGTC_1323 1348-1351 11.2 µM 1.10294813083051 0.0934604299466007 no 315 0.135024845431315 664 6989654
SGTC_563 tetrahydrosecaminediol 614 µM 1.10262146289081 0.0935237500364398 no 316 0.135095792812605 736 334274 A psychoactive constituent of the cannabis plant.
SGTC_402 epigallocatechin gallate 10 µM 1.10142248810599 0.093756426367629 no 317 0.135356411243499 726 65064 An antioxidant.
SGTC_2876 9059903 25.97 µM 1.0984015003106 0.0943445819335032 no 318 0.136014603775617 762 6916095
SGTC_2919 7978188 46.38 µM 1.09824745096936 0.0943746465215839 no 319 0.136048225623452 716 2980291
SGTC_356 1634-0012 32.5 µM 1.09682355942232 0.0946528706586913 no 320 0.136359264627663 741 735457
SGTC_1180 1193-0155 285 µM 1.09465776901105 0.0950772180398258 no 321 0.136833298303028 659 2921347
SGTC_634 1611-4317 11.2 µM 1.09286915600119 0.0954287194382676 no 322 0.137225626207316 775 2843522
SGTC_361 000s-0510 1.45 µM 1.09186141439334 0.0956271834187399 no 323 0.13744700995071 707 660
SGTC_2780 5215298 71.43 µM 1.08969502496264 0.0960548586788072 no 324 0.137923754182613 754 2834131
SGTC_1229 0139-0193 12.2 µM 1.08673012947344 0.0966424472395147 no 325 0.138578047200242 762 3090752
SGTC_564 3555-0129 330 µM 1.08547507870733 0.0968919693373311 no 326 0.138855647788332 636 563260
SGTC_2576 guaiol 23.12 µM 1.08171853514749 0.0976416503128449 no 327 0.139688807285326 767 227829
SGTC_2811 7967822 32.47 µM 1.08130159692905 0.0977251188069569 no 328 0.139781488657982 718 2232244
SGTC_3040 9091894 49.47 µM 1.08040433196589 0.0979049231917098 no 329 0.139981083817692 646 25236966
SGTC_3176 9106582 49.47 µM 1.07592920771785 0.0988053217662362 no 330 0.140979459065848 567 17018027
SGTC_2453 5731132 22.18 µM 1.07581773324081 0.0988278276133235 no 331 0.141004389897686 776 1362040
SGTC_3041 9091929 49.47 µM 1.0727439159877 0.0994498864373291 no 332 0.141693015241798 752 25236887
SGTC_2462 5162487 171.77 µM 1.06863521473207 0.100285841104089 no 333 0.142617037128646 752 2259986
SGTC_1257 0669-0121 16 µM 1.06771122375518 0.100474540272805 no 334 0.14282539700615 809 4307855
SGTC_3325 9138760 55.175 µM 1.06720705132344 0.100577612490446 no 335 0.142939174564437 717 43844959
SGTC_1120 ficusin 1.78878 µM 1.06638420050834 0.100746000456179 no 336 0.143125000411982 751 6199 A DNA cross-linker.
SGTC_1920 st075728 45.7 µM 1.06603541531426 0.100817437772588 no 337 0.143203816412869 729 3400306
SGTC_3150 9097574 49.47 µM 1.06603000495401 0.100818546199979 no 338 0.143205039238508 722 17217476
SGTC_1698 5-fluorocytosine 1.055 µM 1.06518415313228 0.100991946250377 no 339 0.143396301663912 741 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_605 1315-0399 119 µM 1.06355483386357 0.10132657004622 no 340 0.143765206182063 772 24020461
SGTC_1749 st037932 54.2 µM 1.06312109899918 0.101415784953301 no 341 0.143863518672964 685 594497
SGTC_186 3455-3465 67.277 µM 1.0613769609937 0.101775114296846 no 342 0.144259311422748 657 755278
SGTC_190 3970-0790 3.722 µM 1.05980382523883 0.102100007734874 no 343 0.144616928104419 721 2832352
SGTC_551 k048-0028 34.9 µM 1.05832333830349 0.102406455402824 no 344 0.144954028220233 795 6836383
SGTC_2685 mycophenolic acid 18.85 µM 1.05736594762798 0.102604982566174 no 345 0.145172303139217 720 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2602 kawain 100 µM 1.05600938797115 0.102886761337716 no 346 0.145481962907076 806 5369129
SGTC_2856 9022925 19.48 µM 1.05436579267873 0.103228914662164 no 347 0.145857738608638 748 4944862
SGTC_1127 asiatic acid 681.4 nM 1.05364450528121 0.1033793283003 no 348 0.146022852536846 722 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1091 telmisartan 47.6 µM 1.04778782732217 0.104606544160055 no 349 0.147368186021127 772 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_797 k781-0471 270 µM 1.0475646824031 0.104653510040826 no 350 0.147419608228089 778 23738129
SGTC_333 3486-0131 40.1 µM 1.04613960900691 0.104953809135097 no 351 0.147748290112034 785 6744690
SGTC_1460 k062-0059 9.15 µM 1.04279464240427 0.105661127797862 no 352 0.148521706608765 748 1373085
SGTC_2278 7948257 134.34 µM 1.04238799683709 0.105747350508523 no 353 0.148615914608539 767 1247028
SGTC_1140 3229-1848 2.98 µM 1.03844019911838 0.106587062980176 no 354 0.149532581305968 782 2849525
SGTC_566 0958-0068 16.5 µM 1.0383571426182 0.106604780981584 no 355 0.149551907215692 679 6815365
SGTC_925 2064-1272 59.6 µM 1.03810845007501 0.1066578459519 no 356 0.149609783931831 720 6815817
SGTC_2492 derrusnin 100 µM 1.03680833460025 0.10693556949538 no 357 0.149912595244329 692 1715307 Part of coumarin class of compounds.
SGTC_586 0957-0265 8.15 µM 1.03246254955748 0.107867677816147 no 358 0.150927741496497 679 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1946 st076057 65.1 µM 1.03228763254387 0.107905317117658 no 359 0.150968696498672 631 953009
SGTC_1009 4106-0057 9.87 µM 1.03073000420717 0.108240910642815 no 360 0.151333725168694 822 2928005
SGTC_1059 3448-6867 171 µM 1.0292391962939 0.108562810545975 no 361 0.151683643857472 797 3934407
SGTC_1630 st005209 31.3 µM 1.02900722885266 0.108612959526986 no 362 0.151738138979629 850 3367314
SGTC_2799 7812892 81.82 µM 1.02488665596599 0.109506563370868 no 363 0.152708335817949 822 20205235
SGTC_961 1252-1571 372 µM 1.02412159596138 0.109673056824187 no 364 0.15288892258824 795 6813498
SGTC_2327 6189656 200 µM 1.0233256991545 0.109846453813646 no 365 0.153076938378985 772 5349088
SGTC_2929 9013348 24.6 µM 1.0229857696664 0.109920572027864 no 366 0.153157287073673 727 2995952
SGTC_571 k831-0106 44.2 µM 1.02111325595003 0.110329498236014 no 367 0.153600391696259 740 4783639
SGTC_2456 5770359 74.46 µM 1.01769268782124 0.111079308333775 no 368 0.154412011665264 815 3118787
SGTC_1567 st069303 68.4 µM 1.01734624658209 0.111155453470986 no 369 0.154494371819443 796 5581319
SGTC_3207 9114163 49.47 µM 1.01544271619542 0.111574501806149 no 370 0.154947419846639 833 849233
SGTC_1194 1488-0194 225 µM 1.01460376513719 0.111759549200667 no 371 0.15514737192896 814 1391452
SGTC_769 0302-0231 76 µM 1.01457494902283 0.111765909066846 no 372 0.15515424286565 867 571869 YER009W NTF2
SGTC_2742 clothiapine 36.27 µM 1.01266250197251 0.112188574930546 no 373 0.155610697304572 736 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1209 2323-2347 50.3 µM 1.01099866881659 0.112557223448154 no 374 0.156008533460598 790 5412760
SGTC_2638 epoxomicin 18 µM 1.00977914639094 0.112827976866535 no 375 0.156300556646384 829 9915668 A protesome inhibitor.
SGTC_1709 st033179 39.1045 µM 1.0084904773281 0.11311458686645 no 376 0.156609528493882 815 573381
SGTC_210 3551-0445 56.827 µM 1.00713111368452 0.113417482534927 no 377 0.156935885576813 786 2865180 YOR207C RET1
SGTC_327 1273-0057 3.96 µM 1.00600180592778 0.113669556307803 no 378 0.157207350671883 759 3108138
SGTC_3108 9121785 49.47 µM 1.00567161159549 0.113743334674 no 379 0.157286781701359 790 17140271
SGTC_2360 9040895 200 µM 1.00440133525694 0.114027482449611 no 380 0.157592603341362 740 4914414
SGTC_759 3486-0358 89.3 µM 1.00395381806501 0.11412770781109 no 381 0.157700437029852 870 875103
SGTC_1519 esterone 74 µM 1.00183463751273 0.114603168790627 no 382 0.158211732587045 799 698 A steroid.
SGTC_1795 st049545 62.3 µM 1.00145827560439 0.114687756834845 no 383 0.158302651210392 793 5291882
SGTC_2586 curcumin 80 µM 1.00099563791082 0.114791796381108 no 384 0.158414458636965 893 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_113 0099-0221 2.5 µM 0.998051530536129 0.115455450715058 no 385 0.159127185823993 779 89219
SGTC_1971 st069429 63.5 µM 0.996674832651579 0.115766716760599 no 386 0.159461184784875 791 1246522 YGL099W LSG1
SGTC_1914 st062367 72.6 µM 0.991045326313495 0.117045726347455 no 387 0.160831724035466 765 978205
SGTC_502 l-744,832 89.3 µM 0.987312906293936 0.117899223670826 no 388 0.161744632751632 828 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2196 6573537 42.6665 µM 0.984577048305618 0.118527626281435 no 389 0.162415934061041 824 2903087
SGTC_287 k060-0039 29.6 µM 0.981142334088926 0.119319896368619 no 390 0.163261278249061 832 5861974
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.980547375752565 0.119457511601517 no 391 0.163407998032383 794 641818 YHR062C RPP1
SGTC_1086 cerivastatin 2.18 µM 0.979275151361252 0.119752155676127 no 392 0.163722022391121 795 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1188 1403-0014 4.57 µM 0.979113655085715 0.119789594444638 no 393 0.163761912672023 869 9614867
SGTC_2004 4023728 41.89 µM 0.978640296509284 0.119899378032409 no 394 0.163878870636296 832 360084 YDR527W RBA50
SGTC_1809 st050081 57.6 µM 0.97863369080703 0.119900910560163 no 395 0.163880503163977 820 5036894
SGTC_1230 0170-0365 3.77 µM 0.977429715647098 0.120180464341974 no 396 0.164178228822137 951 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2211 7117706 200 µM 0.977088081016697 0.120259872860753 no 397 0.164262773981608 791 822771
SGTC_2627 acetyl isogambogic acid 100 µM 0.976772083116301 0.120333355357602 no 398 0.1643409998854 766 6857789 A caspase activator and apoptosis inducer.
SGTC_2021 4019055 173 µM 0.975158413141735 0.120709093079727 no 399 0.164740843589125 920 44827708 YER133W GLC7
SGTC_2741 miltefosine 3.04 µM 0.971446719733845 0.121576481183373 no 400 0.165662936499798 738 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_801 0866-0028 10.1 µM 0.971426079603524 0.121581316805851 no 401 0.165668073423414 851 6849771
SGTC_3195 9113082 49.47 µM 0.96832019446773 0.122310512732401 no 402 0.166442241120948 803 17018038
SGTC_716 1683-5115 658 µM 0.964902944705579 0.12311635114201 no 403 0.167296713189929 932 723597
SGTC_2184 6075246 200 µM 0.960781592586039 0.124093168439217 no 404 0.168330997905679 835 2267320
SGTC_1416 3966-0321 25.3 µM 0.960572441142015 0.12414288438538 no 405 0.168383595474755 862 582530 YLR208W SEC13
SGTC_1805 st050013 60.3 µM 0.960041637088847 0.124269120706436 no 406 0.168517129938456 816 4037144
SGTC_2075 5212009 200 µM 0.956916399255585 0.125014188217226 no 407 0.169304726582277 766 780898
SGTC_23 0213-0011 39.996 µM 0.95659708954971 0.12509048807523 no 408 0.169385329208231 836 627608
SGTC_2157 5649910 96.377 µM 0.956551226083919 0.125101449936481 no 409 0.169396908441462 829 2858091
SGTC_1115 galangin 695.678 nM 0.952748439264692 0.126012691695883 no 410 0.170358772098796 925 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1138 3761-0006 1.03 µM 0.952297415659273 0.126121074317625 no 411 0.170473084056327 859 12061087
SGTC_83 0170-0301 39.027 µM 0.95218403358571 0.126148330662922 no 412 0.170501828473563 790 3089716
SGTC_1560 lithocholic acid 53.1 µM 0.949181733046262 0.126871559264282 no 413 0.171264095237711 794 9903 A bile acid which acts as a detergent.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.948806525115532 0.126962146159922 no 414 0.171359511296169 876 6728940
SGTC_85 0868-0259 160.055 µM 0.947970109546527 0.127164244973277 no 415 0.17157233557545 808 83173
SGTC_2551 apiole 73.87 µM 0.947454490439843 0.127288942846427 no 416 0.171703617944376 724 10659 A possible DNA adduct former.
SGTC_743 1275-0778 158 µM 0.947168889669664 0.127358049434754 no 417 0.171776362689725 888 2849257 YMR203W TOM40
SGTC_1490 4089-0339 670 nM 0.947129717015348 0.12736753004508 no 418 0.17178634180538 837 742542
SGTC_131 0141-0277 33.849 µM 0.946913673643387 0.127419825926394 no 419 0.171841384855281 852 1547771
SGTC_1235 benzylparaben 21.5 µM 0.946156471601673 0.127603233614498 no 420 0.172034392009785 815 7180
SGTC_1656 st012921 11 µM 0.942233313336138 0.128556430293357 no 421 0.173036600854832 808 6732821
SGTC_937 3122-0005 46.7 µM 0.940886505091196 0.12888479635666 no 422 0.173381511966344 914 759535
SGTC_2063 5246145 200 µM 0.940427348151674 0.128996876522661 no 423 0.173499199819449 886 711240
SGTC_3252 9135871 49.47 µM 0.939577486530147 0.129204505953605 no 424 0.173717164433559 862 17682838
SGTC_1338 1486-1223 76 µM 0.937200347591574 0.129786493836884 no 425 0.174327755516071 899 3444526
SGTC_1760 st045453 10.4495 µM 0.935060538690267 0.130311927224944 no 426 0.174878550767444 921 3323419 YIL048W NEO1
SGTC_1368 1852-0141 284 µM 0.933184792572943 0.130773728446188 no 427 0.175362282586061 836 2838987
SGTC_3177 9107506 49.47 µM 0.932375213453807 0.130973392661781 no 428 0.175571324902581 847 8897194
SGTC_1882 5615643 20 µM 0.928365684697338 0.131965355742947 no 429 0.176608956190642 843 2253075
SGTC_2647 atorvastatin 60.16 µM 0.927493616403237 0.132181790950983 no 430 0.176835152327245 865 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2954 9074818 52.69 µM 0.927425116164014 0.132198802117274 no 431 0.176852927599037 847 16648742
SGTC_1923 st058458 19.1 µM 0.925247670699724 0.132740329728801 no 432 0.177418545942078 940 3534982
SGTC_930 2810-3379 265 µM 0.924492180704236 0.13292857552604 no 433 0.17761506036211 952 1015764
SGTC_1179 1021-1431 9.29 µM 0.923569364696827 0.133158763286848 no 434 0.177855285101637 919 2840958
SGTC_604 1000-0114 314 µM 0.922504399173654 0.133424749684561 no 435 0.178132768365817 942 1572745
SGTC_2048 5246248 200 µM 0.920826006862813 0.133844687344523 no 436 0.178570637345414 883 677046
SGTC_2476 5806916 10.51 µM 0.91954677031891 0.134165364746639 no 437 0.178904827010172 859 2870194
SGTC_1210 3013-0140 750 nM 0.91876766835607 0.134360927435147 no 438 0.179108553507034 952 905973
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.917383293380841 0.134708902654489 no 439 0.179470912058503 874 115019
SGTC_1208 2323-2347 50.3 µM 0.916529429447577 0.134923837199556 no 440 0.179694639566673 910 5412760
SGTC_380 3970-0968 6 µM 0.916457950593787 0.134941840514164 no 441 0.17971337624067 855 2891601
SGTC_1938 st074717 56.4 µM 0.916420262437391 0.13495133365964 no 442 0.179723255890215 831 17250979
SGTC_72 0744-0168 198.391 µM 0.914701014512957 0.135384876487887 no 443 0.180174305812796 854 677577
SGTC_715 0868-0130 184 µM 0.913752223881481 0.135624541390831 no 444 0.180423527910892 892 2876258
SGTC_514 4466-0038 2.65 nM 0.912543924326837 0.135930178899358 no 445 0.180741229034359 930 5722064
SGTC_3125 9127534 49.47 µM 0.912418993864405 0.135961806746305 no 446 0.180774097297369 797 1639235
SGTC_2640 pentamidine 10.38 µM 0.911800496571359 0.136118461967376 no 447 0.180936874463351 963 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2603 homopterocarpin 100 µM 0.910667318615329 0.136405797776511 no 448 0.181235344382821 880 101795 A weak amylase inhibitor.
SGTC_726 3448-4391 34.2 µM 0.910372954443849 0.136480506470317 no 449 0.181312927953443 931 1356692
SGTC_2335 9018011 154.17 µM 0.909729185478114 0.136643990511893 no 450 0.181482674241951 933 6458208
SGTC_33 0986-0033 35.816 µM 0.908852938062127 0.136866727154465 no 451 0.181713879258201 869 2848082
SGTC_940 3232-1287 54.8 µM 0.906876138137096 0.137370128414306 no 452 0.182236150485336 909 1585493 YIL048W NEO1
SGTC_3105 9121040 49.47 µM 0.904696072812887 0.137926756483256 no 453 0.182813211102868 710 41448907
SGTC_398 bronopol 33.3 µM 0.901154826903815 0.138834205311583 no 454 0.183753002640501 908 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_474 dl-dihydrosphingosine 5 µM 0.899229579644056 0.139329254720188 no 455 0.184265193906246 922 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_541 4513-1321 94 µM 0.896687788764678 0.13998467686257 no 456 0.18494276921105 852 747515
SGTC_1256 0570-0116 285 µM 0.89561798114665 0.140261161232919 no 457 0.185228414438073 854 410638
SGTC_3261 9137475 49.47 µM 0.893912545443904 0.140702685732406 no 458 0.185684342439589 738 17027690
SGTC_2819 7996655 46.38 µM 0.893654472269237 0.140769581013012 no 459 0.185753395842007 814 6456960
SGTC_852 0418-0143 439 µM 0.893262239749279 0.140871293125287 no 460 0.185858377156345 988 5369229
SGTC_2201 6605497 169.863 µM 0.89169986523647 0.141276936360001 no 461 0.186276912901213 925 670741
SGTC_3202 9113761 49.47 µM 0.881584747810611 0.1439222987493 no 462 0.189000703042902 989 4798415
SGTC_259 usnic acid 108.925 µM 0.880595839467321 0.144182704950883 no 463 0.189268305646084 946 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.879994891283972 0.144341105871499 no 464 0.189431038546937 962 94937 An inhibitor of serotonin biosynthesis.
SGTC_868 0527-0199 213 µM 0.877921824247235 0.144888435149467 no 465 0.189993072340325 932 2849450
SGTC_2504 purpurogallin 52.29 µM 0.876976555551307 0.145138467390264 no 466 0.190249686116783 895 5281571 An antioxidant.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.875774772640438 0.1454567690271 no 467 0.190576243534895 874 1241132 A phosphatase inhibitor.
SGTC_2425 5628681 7.85 µM 0.875666267712373 0.145485530499722 no 468 0.190605744230529 1014 5714958
SGTC_372 0155-0182 15.9 µM 0.875514145968145 0.145525859950085 no 469 0.190647108336967 983 771486
SGTC_1895 st058434 18.3 µM 0.87521672555512 0.145604731681914 no 470 0.190727997172628 981 5393175
SGTC_2532 xanthone 78.9 µM 0.873094274952048 0.146168410208287 no 471 0.191305847073651 862 7020 An insecticide.
SGTC_1624 st003710 6.25 µM 0.871353486091438 0.146631819990346 no 472 0.191780587339313 999 24207033
SGTC_2711 st079103 59.1 µM 0.870623837699143 0.146826350250425 no 473 0.191979788186998 943 54693780
SGTC_922 1866-0035 480 µM 0.86832155352781 0.147441292665972 no 474 0.192609163056273 1032 3156169
SGTC_2477 5967686 25.23 µM 0.866389798499451 0.147958595979591 no 475 0.193138218218976 935 776118
SGTC_2663 amphotericin b 100 µM 0.865291056826994 0.148253368621106 no 476 0.193439529082496 943 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1702 st027038 51 µM 0.863114402285713 0.148838485293497 no 477 0.194037285056775 967 5521182
SGTC_592 k241-0073 46.5 µM 0.861623293113421 0.149240206824363 no 478 0.194447424399082 999 4230158
SGTC_1389 3405-0187 19 µM 0.859755235051745 0.149744503402981 no 479 0.194961990037906 881 799890
SGTC_2555 cholic acid 100 µM 0.85816696352986 0.150174162598174 no 480 0.195400137692685 944 6708657 Influences liver metabolism.
SGTC_1012 4112-3522 18 µM 0.856748504574488 0.150558578081075 no 481 0.195791945283822 997 3112398
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.856684527057581 0.150575932013189 no 482 0.195809628422983 1013 676296 Flavone; oxidizing agent.
SGTC_2768 sulfasalazine 50.2 µM 0.853739683391784 0.151376164317707 no 483 0.196624620594205 993 5384001 An antioxidant and salicylic acid derivative.
SGTC_893 0958-0369 48.9 µM 0.852740614519978 0.15164829279549 no 484 0.196901581343433 998 6819948
SGTC_3168 9103419 49.47 µM 0.852492020970238 0.151716055717342 no 485 0.19697053284667 919 16649256
SGTC_3162 9099653 49.47 µM 0.852138895101428 0.151812347191646 no 486 0.197068503228583 949 25237511
SGTC_383 2324-0395 7.37 µM 0.851710872050282 0.151929116294895 no 487 0.197187292430878 988 3146421
SGTC_2443 5493264 126.67 µM 0.850665453501198 0.152214568026239 no 488 0.197477609428047 980 5340055
SGTC_704 1310-0270 142 µM 0.848884841962584 0.152701583606543 no 489 0.197972687105565 1014 5718033
SGTC_3324 9138759 60.749 µM 0.845535195366398 0.153620544555749 no 490 0.198906045307961 987 45595710
SGTC_593 1203-0218 61.7 µM 0.84492596562144 0.153788076842264 no 491 0.199076088001055 1022 3666956
SGTC_3030 9087619 49.47 µM 0.844390599459288 0.153935397153275 no 492 0.199225586833679 1003 25236973
SGTC_489 paxilline 115 µM 0.842935293898152 0.154336335203369 no 493 0.199632316609219 960 105008 A toxic potassium channel blocker.
SGTC_625 k213-0058 121 µM 0.842237688282818 0.154528770817601 no 494 0.199827460928849 1108 3655420
SGTC_184 1494-0393 24.714 µM 0.841465506784587 0.154741963162571 no 495 0.200043600427681 971 3090647
SGTC_492 tmb-8 126 µM 0.841069038525004 0.154851499939805 no 496 0.200154629506599 847 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_413 propylparaben 100 µM 0.839566060324668 0.155267209762926 no 497 0.200575867733281 948 7175 A pharmaceutical preservative.
SGTC_674 0498-0004 451 µM 0.839251910488254 0.155354193678166 no 498 0.200663981413487 936 4231473
SGTC_887 0885-0007 9.62 µM 0.838407757906314 0.155588087586467 no 499 0.200900866930813 1007 5719458
SGTC_808 0711-0032 135 µM 0.837750715814255 0.155770298455833 no 500 0.201085361705446 1004 4252555
SGTC_2461 5755302 26.15 µM 0.837502769167263 0.155839095556517 no 501 0.20115501052669 992 2788904
SGTC_2921 7974240 10.71 µM 0.83744196651705 0.155855969365253 no 502 0.201172092348744 965 2979074 YDR527W RBA50
SGTC_46 0329-0187a 2.197 µM 0.836162425912227 0.15621134385385 no 503 0.201531766641134 1026 46494817
SGTC_939 1165-0479 45.3 µM 0.834331649050556 0.156720744141809 no 504 0.202047060989743 989 1377347
SGTC_538 2922-0838 53.3 µM 0.834059726999182 0.156796497614443 no 505 0.202123663947751 1054 777039
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.832055570350734 0.157355569255926 no 506 0.20268878927213 1010 688798
SGTC_2959 9079155 11 µM 0.830955507570766 0.15766299477505 no 507 0.202999382233926 950 16189457
SGTC_1854 st056233 32.9 µM 0.829737786853442 0.15800376102405 no 508 0.203343526103758 967 5393174
SGTC_2166 5933061 31.504 µM 0.828941318738952 0.158226905559325 no 509 0.203568806652356 1105 2877375
SGTC_299 1273-0059 1.44 µM 0.828618199796657 0.158317491947001 no 510 0.203660243086183 970 2848077
SGTC_659 k018-0002 107 µM 0.82805854056088 0.158474472893588 no 511 0.20381867379445 1007 6797879 YHR007C ERG11
SGTC_373 0844-0104 25.9 µM 0.827563463319955 0.158613424065958 no 512 0.203958883574328 1055 5375804
SGTC_2277 7947813 106.88 µM 0.827546697316755 0.158618131105178 no 513 0.203963632844595 955 1246798
SGTC_822 1487-0950 154 µM 0.826841313496611 0.158816249924398 no 514 0.204163505127954 1010 1958375
SGTC_3247 9135149 49.47 µM 0.826830484019103 0.158819292827582 no 515 0.20416657459664 950 8934436 YOR116C RPO31
SGTC_1654 st012436 41.8 µM 0.826709230233394 0.158853365735344 no 516 0.204200944216135 966 4323132
SGTC_1007 4101-0031 70 µM 0.826645061681993 0.158871399351142 no 517 0.204219134309986 1023 1146276
SGTC_865 0488-0499 301 µM 0.82429503078005 0.159532764877983 no 518 0.204885970718799 1058 9634651
SGTC_3027 9089541 49.47 µM 0.823517920289176 0.159751861793604 no 519 0.205106765363636 1011 9943819
SGTC_1790 st045711 43.5 µM 0.82179938690996 0.160237080260281 no 520 0.205595541368325 1014 585119
SGTC_151 3013-0144 2.285 µM 0.820777355534526 0.160526101532488 no 521 0.205886549621619 995 906558 YHR107C CDC12
SGTC_2160 5660466 132.927 µM 0.820303818767302 0.160660128844712 no 522 0.206021464978491 959 2859134
SGTC_1435 4092-0789 56.7 µM 0.81907509966893 0.161008239668416 no 523 0.206371783766805 1033 2248285
SGTC_1508 1080-0625 72.9 µM 0.81759127140119 0.161429281671616 no 524 0.206795306643033 966 767111
SGTC_3213 9129884 49.47 µM 0.815127906037774 0.162129855061138 no 525 0.207499549751688 978 17190742
SGTC_1661 st013063 9.66 µM 0.814135784391834 0.162412569789435 no 526 0.207783583953011 1085 721395
SGTC_1832 st054113 55 µM 0.814061879347257 0.162433642584887 no 527 0.207804751391921 1014 1251267
SGTC_1851 st056236 18.9 µM 0.813295575707348 0.162652246208189 no 528 0.208024306532448 1060 5393171
SGTC_1044 1222-0021 1.78 µM 0.813025291289405 0.162729395943984 no 529 0.20810177889998 979 4306703
SGTC_217 ketoconazole 989 nM 0.812865654795627 0.16277497361656 no 530 0.208147543945982 993 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2175 5807670 165.306 µM 0.811170554671253 0.16325945220735 no 531 0.208633866362932 1020 241186
SGTC_43 0570-0105 72.5 µM 0.810002955843321 0.163593709403263 no 532 0.208969238455184 1062 1114046 YDL195W SEC31
SGTC_2886 9058944 51.95 µM 0.809467097470455 0.163747262222425 no 533 0.209123260532665 894 4949929
SGTC_2255 7941087 197.44 µM 0.807965189734281 0.164178139587817 no 534 0.209555310798225 1083 935561
SGTC_2813 7971799 71.43 µM 0.807064397476395 0.164436917357662 no 535 0.209814691285553 992 2234054
SGTC_645 0845-0943 5.41 µM 0.804954805431367 0.165043990748803 no 536 0.210422880187195 992 1885106
SGTC_2393 9031399 185.94 µM 0.803513593786753 0.165459558748701 no 537 0.210838971430451 1053 1526623 YDL150W RPC53
SGTC_2801 7907800 81.82 µM 0.801684328692919 0.165987994452158 no 538 0.21136779160956 1041 6620925
SGTC_773 4358-1457 44.6 µM 0.80159009485168 0.166015246106755 no 539 0.211395054589149 1087 1186886
SGTC_1161 k007-0610 110 µM 0.800653442380771 0.166286275495897 no 540 0.211666151328121 1107 5843850
SGTC_2917 7979103 53.79 µM 0.800179369314319 0.166423561947831 no 541 0.211803440536453 1050 2980565
SGTC_3340 9146634 11.102 µM 0.799670581324083 0.166570982858485 no 542 0.211950840965055 1031 4907387
SGTC_919 tnp00227 403.569 nM 0.799431353502813 0.166640328051463 no 543 0.21202016813667 1048 1269246 A methoxyflavone. YNL221C POP1
SGTC_3315 9136395 68.55 µM 0.799093299112578 0.166738351955838 no 544 0.212118157421316 1086 16876844
SGTC_1501 4491-0275 38.4 µM 0.798460792696271 0.16692185651671 no 545 0.212301568403878 1052 5104718
SGTC_41 0478-0632 82.643 µM 0.798043260057374 0.167043063622712 no 546 0.212422693157192 1095 3750424
SGTC_2898 9056270 58.44 µM 0.795508614745221 0.167780072871426 no 547 0.213158850893768 993 19154699
SGTC_1014 4130-3005 69.3 µM 0.792890573573634 0.168543526257431 no 548 0.213920789921479 1071 743608
SGTC_3260 9137109 49.47 µM 0.792099838307914 0.16877455296429 no 549 0.214151232187922 920 17478346
SGTC_2182 6325192 200 µM 0.790637927189633 0.169202210681395 no 550 0.214577653956293 1010 736248
SGTC_2262 9014885 67.46 µM 0.789979869158082 0.169394941459779 no 551 0.214769762492304 1005 6457424
SGTC_2015 5119600 184 µM 0.78821618222407 0.169912181240904 no 552 0.215285132609436 1056 2828786
SGTC_1356 1502-0781 85.8 µM 0.787337372393176 0.170170289019769 no 553 0.215542198865232 1001 567702
SGTC_466 geldanamycin 89.2 µM 0.787046374972891 0.170255810743605 no 554 0.215627359589484 961 5288382 HSP90 inhibitor.
SGTC_512 prima-1 270 µM 0.785529057368025 0.170702183792901 no 555 0.216071720265082 1076 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_386 1509-0011 3.07 µM 0.784416145825905 0.171030062162667 no 556 0.216397983761299 1123 3107280
SGTC_992 3909-8734 162 µM 0.783615941741291 0.171266061594745 no 557 0.216632749386984 1080 4288319
SGTC_1774 st048371 48.465 µM 0.78321250222608 0.171385124520911 no 558 0.216751167195239 1081 4242727
SGTC_2420 aureobasidin a 50 nM 0.783089180696102 0.171421529682482 no 559 0.216787372073047 1081 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1932 st074806 40.9 µM 0.78292416115954 0.171470252045379 no 560 0.216835824169764 1189 17251235
SGTC_1972 st070201 17.4 µM 0.782711507968401 0.171533051393794 no 561 0.21689827142056 1059 2829099
SGTC_2076 5212012 200 µM 0.77551352414676 0.173667377126715 no 562 0.219018138575852 980 604802
SGTC_2941 9056145 11.23 µM 0.775240261590208 0.173748735669 no 563 0.219098850787161 1006 2119517
SGTC_3328 9140624 29.0385 µM 0.774953755305714 0.173834063302035 no 564 0.219183493096374 1098 4904392
SGTC_431 k089-0097 107 µM 0.770539083784708 0.175152213768855 no 565 0.220490090107365 1079 5499420
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.770019879451429 0.175307655486219 no 566 0.22064405024675 1086 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1659 st012954 42.1 µM 0.768510913185472 0.175759912896222 no 567 0.221091854815319 1046 24207262
SGTC_2167 5876490 200 µM 0.76846016743378 0.175775134912707 no 568 0.221106923283459 1095 686534
SGTC_4 0960-0234 25.671 µM 0.768407162132138 0.175791035609774 no 569 0.221122663330911 1064 6821112
SGTC_2045 5106652 78.05 µM 0.768165770476514 0.175863460560325 no 570 0.221194353251496 1085 673349
SGTC_3218 9131285 49.47 µM 0.768116980898502 0.175878101235823 no 571 0.221208844683884 1097 17156417
SGTC_2025 5147754 141 µM 0.767001944039766 0.176212909579371 no 572 0.221540179840821 1078 315777 YLR208W SEC13
SGTC_1489 4065-0444 182 µM 0.765747454432895 0.176590072790395 no 573 0.221913292508075 1082 2877968
SGTC_1248 0469-0687 58.6 µM 0.763530856007034 0.177257741621911 no 574 0.222573433820676 1079 4017482
SGTC_3136 9095672 49.47 µM 0.762035957583371 0.177708923753154 no 575 0.223019271841701 950 17217380
SGTC_2858 9025781 8.96 µM 0.761983204275772 0.177724858694735 no 576 0.223035014256351 1155 4894980 YPL153C RAD53
SGTC_1507 4075-3230 155 µM 0.761873157868115 0.17775810279312 no 577 0.223067855867851 1022 659771
SGTC_2289 7946404 165.07 µM 0.760920101249576 0.178046177306197 no 578 0.223352395728043 1157 1246120 YPR165W RHO1
SGTC_323 4013-0906 34.3 µM 0.760026263226044 0.178316619501827 no 579 0.223619443162385 1123 2910086
SGTC_1925 st057770 10.1 µM 0.759398586376216 0.178506685833004 no 580 0.223807079448255 1054 5989122
SGTC_1720 st037298 9.481 µM 0.758568063099523 0.178758371980785 no 581 0.22405549167404 1063 597396
SGTC_2567 aureobasidin a 60 nM 0.758057119879692 0.178913321847103 no 582 0.224208394246492 1086 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_775 4577-0580 57.3 µM 0.757825838830333 0.178983488475573 no 583 0.224277625850083 1121 2006902
SGTC_2249 haloperidol 116.36 µM 0.757225774185233 0.17916561833326 no 584 0.224457305614145 1148 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1621 st003705 32.4 µM 0.755764952786045 0.179609489684138 no 585 0.224895066557504 1139 24207032
SGTC_3071 9117417 49.47 µM 0.754404865890379 0.180023373461559 no 586 0.225303075337622 1027 45595590 YGL055W OLE1
SGTC_589 1227-0070 34.1 µM 0.753072307901176 0.18042946028674 no 587 0.225703232021598 1084 2841384
SGTC_2187 6125751 200 µM 0.752550524251667 0.180588626295171 no 588 0.225860029023188 1094 874498
SGTC_2864 9034755 47.6 µM 0.752087142685848 0.180730051006069 no 589 0.225999327713698 1135 4930451
SGTC_1054 3429-0080 167 µM 0.750708965090892 0.181151082990765 no 590 0.226413913218163 1137 1162877
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.750377060885961 0.1812525711464 no 591 0.226513821286401 1188 6710655
SGTC_585 0kpi-0023 191 µM 0.749741462219947 0.181447020974772 no 592 0.2267052153279 1077 64601
SGTC_2882 9058044 58.44 µM 0.749545501295671 0.181506997976392 no 593 0.226764242274675 1093 18076804
SGTC_1406 3909-7906 11.9 µM 0.748460119572785 0.181839421228722 no 594 0.227091335709227 1131 X1406
SGTC_1686 st019653 115.5 µM 0.746486726257613 0.182444793449088 no 595 0.227686723517094 1129 97252
SGTC_2641 levomentholum 100 µM 0.742768334784991 0.18358889017634 no 596 0.228810974819867 1097 16666
SGTC_2952 9073731 13.78 µM 0.742406852749124 0.183700351067173 no 597 0.228920434432212 1179 16457353
SGTC_3200 9114385 49.47 µM 0.741604235943637 0.183947984000202 no 598 0.229163578159116 1120 17018030 YLR208W SEC13
SGTC_3111 9122088 49.47 µM 0.741326355282277 0.184033767484255 no 599 0.229247792718356 1042 16876704
SGTC_2221 6807166 181.081 µM 0.741189959271265 0.184075882890564 no 600 0.229289135264339 1083 674925
SGTC_3050 9093513 49.47 µM 0.740809673192629 0.184193336647651 no 601 0.229404424597388 1171 25236664
SGTC_320 4092-0846 5.34 µM 0.740539118635494 0.184276927521831 no 602 0.229486466978203 1128 1359356
SGTC_1123 mangostin 811.285 nM 0.74041061155501 0.184316639497727 no 603 0.229525440947035 1054 5281650 An antioxidant.
SGTC_985 1493-0307 8.71 µM 0.739345277268659 0.184646060070105 no 604 0.22984868113791 1117 3278274
SGTC_3127 9126946 49.47 µM 0.739070489754959 0.18473108867879 no 605 0.229932097580174 1013 27243249
SGTC_649 1123-0311 367 µM 0.738260980183908 0.184981719940326 no 606 0.230177936498239 1124 693629 YIL048W NEO1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.737164271548065 0.18532160738496 no 607 0.230511228940275 1143 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2745 rifampicin 24.3 µM 0.73477157835815 0.186064485765922 no 608 0.23123930959563 1050 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.732705190927548 0.186707536751622 no 609 0.231869128632542 1092 77254
SGTC_3338 9144300 39.5675 µM 0.73173676278873 0.18700938037567 no 610 0.232164626597739 1122 4901274
SGTC_735 3076-0345 636 µM 0.729944495759794 0.187568797257785 no 611 0.23271205626174 1168 2888990
SGTC_974 1326-0144 138 µM 0.729635696945934 0.187665286363159 no 612 0.232806448103708 1163 5411856
SGTC_3352 9151559 45.5865 µM 0.728854552106808 0.18790950436454 no 613 0.23304531890255 1123 17159339
SGTC_2754 granisetron 64.02 µM 0.724161924641016 0.189380739443131 no 614 0.2344831655004 1143 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1060 3448-7350 82 µM 0.723377924667708 0.189627228935946 no 615 0.23472386493336 1111 570178
SGTC_2252 omeprazole 400 µM 0.721832855309786 0.190113575941429 no 616 0.235198623419561 1075 4594 A proton pump inhibitor.
SGTC_2545 solidagenone 89.61 µM 0.721555482121434 0.190200966777662 no 617 0.235283908887727 996 6708572 An anti ulcer agent
SGTC_522 1273-0010 11.6 µM 0.720388375172689 0.190568952736737 no 618 0.235642952710789 1213 5705015
SGTC_1450 4112-4260 37.6 µM 0.720178317508384 0.190635229784982 no 619 0.235707606033635 1151 1633175
SGTC_276 colchicine 750 µM 0.719600154507788 0.190817723874882 no 620 0.235885608434978 1204 2833 A microtubule depolymerizer.
SGTC_991 3996-0057 64.7 µM 0.717421932826854 0.191506230167189 no 621 0.236556895183966 1119 715343
SGTC_1961 st076550 68.7 µM 0.713986050179927 0.192595355144432 no 622 0.237617902733081 1129 1579337
SGTC_1312 1218-2183 165 µM 0.712331930575913 0.193121034369302 no 623 0.23812962791299 1190 6744073
SGTC_27 0485-0001 32.618 µM 0.71232612894391 0.193122879668191 no 624 0.238131423791641 1112 2054479
SGTC_3067 9117431 49.47 µM 0.71231961010686 0.193124953098093 no 625 0.238133441687925 1167 17150885
SGTC_2297 7971671 152.32 µM 0.711288385516457 0.193453123177026 no 626 0.238452773676139 1179 909016
SGTC_443 clozapine 122 µM 0.707701465092524 0.194597248043621 no 627 0.239565333702388 1096 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_587 k089-0003 57 µM 0.707265619304356 0.194736550382889 no 628 0.239700713408131 1123 9659696
SGTC_1201 1889-3372 45.9 µM 0.70686723884149 0.194863931336572 no 629 0.239824492378921 1110 5392199
SGTC_2923 7992654 58.14 µM 0.706096553350875 0.195110499496091 no 630 0.240064047486824 1184 2985126
SGTC_651 3253-0966 34.4 µM 0.70523546424354 0.195386215004085 no 631 0.240331857329178 1203 781462
SGTC_2740 felodipine 17.08 µM 0.704566936469411 0.195600436660611 no 632 0.240539890293386 1122 3333 L-type calcium channel blocker
SGTC_2084 5306078 60.6385 µM 0.702961593859443 0.19611543139276 no 633 0.24103984215603 1133 679340
SGTC_813 k007-0158 173 µM 0.700903573021365 0.196776847086278 no 634 0.241681597240903 1209 6523916
SGTC_3106 9121286 49.47 µM 0.699614726230625 0.197191749330413 no 635 0.242083971693855 1215 15943471
SGTC_2520 obtusaquinone 4.71 µM 0.698811317953376 0.197450648052161 no 636 0.242334977244388 1249 5967872
SGTC_539 4859-0462 2.54 µM 0.697753835977257 0.197791735299753 no 637 0.242665576862811 1194 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3160 9100216 49.47 µM 0.696945161146846 0.198052810707959 no 638 0.242918556800352 1157 17191039
SGTC_1688 st021091 57.6 µM 0.696867976599259 0.198077740111255 no 639 0.242942710108643 1199 3656366
SGTC_345 1362-0200 395 µM 0.696536501290513 0.198184822998703 no 640 0.243046453222349 1176 1419823
SGTC_2650 prasterone 100 µM 0.696473876065571 0.198205057962083 no 641 0.243066055972674 1152 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.695384775912523 0.198557158728842 no 642 0.243407099363336 1166 688803
SGTC_1606 st000094 49.2 µM 0.693484701934733 0.199172345940313 no 643 0.244002711504684 1233 1242210
SGTC_169 k015-0017 16.025 µM 0.693240756491641 0.199251411269421 no 644 0.244079237472728 1232 1840002
SGTC_359 0081-0058 15.9 µM 0.692637239002324 0.199447098960637 no 645 0.244268617221417 1261 3494159
SGTC_2428 5615643 7.78 µM 0.692004698334122 0.199652321405356 no 646 0.244467189232857 1212 2253075
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.691332217051332 0.199870641533146 no 647 0.244678395052819 1071 88881 An O-methylated flavonoid and antioxidant.
SGTC_1096 rimcazole 32.2 µM 0.691278378033691 0.199888126501901 no 648 0.244695308489887 1145 18528119 A dopamine reuptake inhibitor.
SGTC_973 1325-0077 65.9 µM 0.689249664307279 0.200547649654778 no 649 0.245333084031922 1236 2835149
SGTC_2348 9022543 33.42 µM 0.68906025621486 0.200609291759701 no 650 0.245392674646779 1195 3162678 YDL140C RPO21
SGTC_1072 oxiconazole 14.9 nM 0.686656634655643 0.201392528525573 no 651 0.246149565138016 1221 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2200 6600604 21.907 µM 0.686044984463497 0.201592131141747 no 652 0.246342370902267 1179 2904777
SGTC_1293 1000-1278 195 µM 0.6845210419635 0.202089961523922 no 653 0.246823103419043 1254 678847
SGTC_1871 st057448 67.3 µM 0.684338564451403 0.202149621221524 no 654 0.246880700179977 1292 691747
SGTC_2077 5212015 200 µM 0.682398737196961 0.202784484862826 no 655 0.247493427023577 1141 780900
SGTC_2994 9053520 71.4286 µM 0.679573560900775 0.203711232047452 no 656 0.248387257620411 1201 4647384
SGTC_3063 1327-0034 4 µM 0.678558995339513 0.204044656902552 no 657 0.24870866574124 1158 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1378 2093-0007 380 nM 0.678508306312135 0.20406132376913 no 658 0.248724729520044 1222 3618014
SGTC_1912 st060209 90.8 µM 0.677506593899195 0.204390859372796 no 659 0.249042293916237 1203 688787
SGTC_1088 bifonazole 369 nM 0.677410666705526 0.204422433371306 no 660 0.24907271621566 1171 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1228 0124-0032 52.5 µM 0.677246882392416 0.20447634894109 no 661 0.249124663255244 1260 X1228
SGTC_712 r015-0009 80.6 µM 0.674976119874143 0.205224724799706 no 662 0.249845468465267 1194 6813872 YLR060W FRS1
SGTC_1909 st060837 51.5 µM 0.674490759476595 0.205384896004503 no 663 0.249999679274407 1195 678937
SGTC_1888 azatryptophan 97.5 µM 0.674470692612413 0.205391519761559 no 664 0.250006056092544 1193 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_646 4092-0839 27.3 µM 0.674450670901665 0.205398128740617 no 665 0.250012418647908 1265 877796
SGTC_941 3237-0776 460 µM 0.672756057079519 0.205957962492111 no 666 0.250551249021578 1238 760008
SGTC_643 k048-0106 28.4 µM 0.67009489935932 0.206838928638835 no 667 0.251398648106723 1250 6763920
SGTC_567 1080-0542 68.4 µM 0.670066812863827 0.206848238445817 no 668 0.251407599830937 1181 5950415
SGTC_1241 0364-0022 50.8 µM 0.669937920704428 0.206890965402074 no 669 0.251448682483833 1238 4563895
SGTC_650 1328-0195 38 µM 0.66947257930377 0.207045266674982 no 670 0.251597033356921 1218 2780821
SGTC_2399 5884133 200 µM 0.667279524843452 0.207773371594732 no 671 0.25229680122586 1250 722445
SGTC_3197 9113331 49.47 µM 0.666546328647104 0.20801713328582 no 672 0.25253098082921 1285 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2935 9038016 29.96 µM 0.666089574956942 0.208169072970047 no 673 0.252676923799349 1231 6463195
SGTC_452 diindolylmethane 8 µM 0.665247562135985 0.208449341169655 no 674 0.252946082015192 1222 3071 Inhibits expression of several cancer promoting factors.
SGTC_2747 doxorubicin 7.63 µM 0.665228277125829 0.208455762887837 no 675 0.252952248437644 1143 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2716 st080858 38.6235 µM 0.665203089012841 0.208464150456741 no 676 0.252960302508747 1218 5296050
SGTC_2496 diffractaic acid 79.83 µM 0.664554111360346 0.208680326756958 no 677 0.25316786406719 1315 94870 An apoptosis inducer which activates caspases.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.664535872656942 0.208686404029153 no 678 0.253173698618348 1245 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2839 9003951 25.97 µM 0.662033642011494 0.209521154432767 no 679 0.253974830722289 1239 2990634
SGTC_2384 9036245 200 µM 0.661819441770882 0.209592703322798 no 680 0.254043472364069 1248 6462766
SGTC_1784 st039334 36.3 µM 0.660027190036406 0.210191928622198 no 681 0.254618190451111 1313 3496984
SGTC_2744 captopril 92.04 µM 0.659617755591322 0.210328960872387 no 682 0.254749578535538 1240 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_39 0986-0283 58.349 µM 0.656485597804929 0.211378986554401 no 683 0.255755865602789 1293 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_161 4065-0411 162.148 µM 0.655912145692194 0.21157156282625 no 684 0.255940326483513 1265 1906281 YLR208W SEC13
SGTC_112 phenothiazine 287.218 µM 0.65516488384586 0.211822661822949 no 685 0.256180800425809 1249 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1249 0481-0015 10.2 µM 0.653466456062885 0.212394024886834 no 686 0.256727803908154 1222 4227577
SGTC_1277 0873-0036 22 µM 0.653196007283926 0.212485088801761 no 687 0.256814961975777 1285 5965735
SGTC_760 0568-0725 82.9 µM 0.653180601639312 0.212490276785932 no 688 0.256819927247193 1266 3916171
SGTC_1486 3970-0793 4.53 µM 0.653104025955637 0.212516065408234 no 689 0.25684460849128 1278 2844330
SGTC_1219 1469-0211 33.1 µM 0.652454009961298 0.212735046856908 no 690 0.257054165999264 1237 6822282
SGTC_1417 3966-0327 90.4 µM 0.650230100448506 0.213485247070268 no 691 0.257771800278982 1309 651118
SGTC_3249 9135183 49.47 µM 0.648260988306742 0.214150780617035 no 692 0.258408080786442 1290 4902779
SGTC_2329 6138490 200 µM 0.648106480866605 0.214203053095253 no 693 0.25845804128382 1291 720019
SGTC_285 1486-1325 46 µM 0.647913542158021 0.214268337942751 no 694 0.25852043568488 1288 22310230
SGTC_2034 5197015 53.07 µM 0.64689495885531 0.214613188708166 no 695 0.258849964345338 1302 780676
SGTC_1676 st018489 23.4 µM 0.646377791148966 0.21478840400803 no 696 0.259017359860261 1292 3696235
SGTC_2336 9001819 198.65 µM 0.646269444374373 0.214825122187876 no 697 0.259052436357653 1344 2989602
SGTC_1770 st043884 66.3 µM 0.64620666941331 0.214846397976475 no 698 0.259072760428475 1270 670149
SGTC_1162 k048-0130 20.1 µM 0.646081195594534 0.214888927428867 no 699 0.259113386401719 1259 6797406
SGTC_2644 guaiazulene 100 µM 0.644991685266704 0.215258423365496 no 700 0.259466286999202 1274 3515 A coloring agent.
SGTC_411 enrofloxacin 100 µM 0.642638057982642 0.216057888643784 no 701 0.260229491089443 1369 71188 A bacterial gyrase inhibitor.
SGTC_2648 atorvastatin 78.68 µM 0.642412337856922 0.21613465010795 no 702 0.260302745466463 1285 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3264 9137442 49.47 µM 0.641990386505087 0.216278186989432 no 703 0.260439712490311 1331 17015726
SGTC_1355 1499-0035 1.68 µM 0.641285161963574 0.216518209200728 no 704 0.260668713906701 1280 1548538
SGTC_2407 paclitaxel 400 µM 0.641138083439214 0.216568286592382 no 705 0.260716486490641 1408 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1183 1254-0324 198 µM 0.640860477893799 0.216662824165937 no 706 0.260806667839537 1303 5799357
SGTC_3319 9138450 16.7555 µM 0.640684628298474 0.216722721462285 no 707 0.260863801634156 1266 2029690
SGTC_2488 5268135 45.7 µM 0.639149233011186 0.217246109306058 no 708 0.261362927206831 1307 1270356 YLR208W SEC13
SGTC_185 k048-0037 25.491 µM 0.638783141837333 0.217371010716121 no 709 0.261482008331461 1284 6827589
SGTC_1998 st075797 76.8 µM 0.636779294525229 0.218055408919345 no 710 0.262134307428251 1283 24208315
SGTC_757 1066-0008 322 µM 0.63661348544709 0.218112095289504 no 711 0.262188319486058 1323 6842497
SGTC_401 neomycin 50 µM 0.636596948766291 0.218117749272064 no 712 0.262193706597646 1269 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1967 st070177 51.4 µM 0.635132751302872 0.218618701253307 no 713 0.262670919116874 1356 5729214
SGTC_500 h-89 112 µM 0.634821059510753 0.218725427106265 no 714 0.262772563317185 1366 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1505 k297-0037 20.6 µM 0.633392288261217 0.219215033822686 no 715 0.263238749862949 1279 4089396
SGTC_111 0083-0039 52.457 µM 0.633149990517215 0.219298126065084 no 716 0.26331784984235 1216 759313
SGTC_219 mitoxanthrone 164.414 µM 0.633042081196533 0.219335137713267 no 717 0.263353081583811 1303 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2563 tomatine 8.54 µM 0.631785240196733 0.219766483944086 no 718 0.263763609781233 1310 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1514 1189-1591 158 µM 0.630457401830989 0.220222724949694 no 719 0.264197682455262 1371 767698 YMR146C TIF34
SGTC_2350 9023895 38.85 µM 0.630033123843559 0.220368619925349 no 720 0.264336456327187 1339 2997209
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.628201853668988 0.220998967636624 no 721 0.264935858071259 1268 756377
SGTC_2536 dehydroabietamide 32.04 µM 0.62768010565431 0.22117874900447 no 722 0.265106760237201 1354 3983547
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.627195277755554 0.221345883592862 no 723 0.265265619141263 1324 165521
SGTC_8 0354-0001 70 µM 0.626818555830756 0.221475800686376 no 724 0.265389089354873 1344 4993152
SGTC_3305 9127027 53.8275 µM 0.62655968070903 0.221565102155178 no 725 0.265473952307184 1258 41905295
SGTC_1728 st035614 33.7865 µM 0.625964369035092 0.221770538716273 no 726 0.265669156174542 1348 15945546
SGTC_3311 9131146 2.8755 µM 0.62324399358707 0.222710698764261 no 727 0.266562097853129 1307 4900406 YPR165W RHO1
SGTC_2188 6126565 140.678 µM 0.620440317419805 0.223682020143607 no 728 0.267483967824437 1289 874518
SGTC_2340 7987427 183.45 µM 0.620286826259074 0.223735265938608 no 729 0.267534483261103 1308 2239331
SGTC_2764 methyldopa 94.69 µM 0.619755896960405 0.223919499873448 no 730 0.267709254354506 1351 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2910 7948405 25.97 µM 0.61956722057537 0.223984991856146 no 731 0.267771376624592 1289 2971328
SGTC_626 0214-0009 33 µM 0.61932964508347 0.224067472820614 no 732 0.267849609402806 1381 3437874
SGTC_774 k060-0086 136 µM 0.619290830348855 0.224080950078806 no 733 0.267862392053208 1327 5911235
SGTC_2285 7945142 200 µM 0.618936932459582 0.224203851795225 no 734 0.267978953536532 1303 2970608
SGTC_2634 4'-methoxyflavone 100 µM 0.618783719030807 0.224257071650259 no 735 0.268029424557202 1318 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_847 0342-0274 5.54 µM 0.61829794772047 0.224425855439706 no 736 0.268189477241475 1316 18097
SGTC_2670 beta-carotene 100 µM 0.61617154079341 0.225165534622389 no 737 0.268890654647749 1248 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2104 5389443 200 µM 0.616067653197553 0.225201707689176 no 738 0.268924934894547 1377 2244536
SGTC_2699 st077704 54.6 µM 0.614997759268182 0.225574430094397 no 739 0.269278100107238 1332 645852
SGTC_1298 1079-1278 263 µM 0.614280085857897 0.225824643801338 no 740 0.269515129832453 1341 2840950
SGTC_1346 1488-2224 62.4 µM 0.614203935836421 0.225851202382703 no 741 0.269540286430352 1318 3722427
SGTC_1875 nocodazole 6 µM 0.610335380734173 0.227202747216964 no 742 0.270819832124509 1319 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2269 7935389 174.42 µM 0.609583716550353 0.227465881655382 no 743 0.27106880047618 1303 97605
SGTC_1552 6-methylflavone 10.6 µM 0.609254552560455 0.227581165831453 no 744 0.271177863040188 1299 689013
SGTC_1763 st044482 94.5 µM 0.607548126500621 0.228179340073327 no 745 0.271743607071417 1339 88505
SGTC_1563 conessine 56.1 µM 0.60742450927761 0.228222707429765 no 746 0.271784613610067 1395 441082 An anti-amoebic, histamine inhibitor.
SGTC_2960 9079389 5.97 µM 0.605558455993974 0.228877918301849 no 747 0.272403998177464 1361 16457355
SGTC_933 2914-0560 114 µM 0.605472344380003 0.22890817937684 no 748 0.272432597450762 1370 463887
SGTC_2032 5185112 25.99 µM 0.6047387303296 0.229166074767095 no 749 0.272676304812981 1271 5718189
SGTC_749 1000-0129 128 µM 0.604166502793253 0.229367349257982 no 750 0.27286647448388 1422 708470
SGTC_457 grayanotoxin iii 135 µM 0.604145931812934 0.229374586709697 no 751 0.272873312108951 1296 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_705 1124-0212 310 µM 0.603601028573212 0.229566345653943 no 752 0.273054464407517 1370 9554485
SGTC_467 ro 31-8220 72.8 µM 0.603429817271231 0.229626615804594 no 753 0.27311139566386 1307 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2014 4013930 200 µM 0.602787601933913 0.229852768716841 no 754 0.273324997790219 1312 64556
SGTC_2948 9070189 9.45 µM 0.60131415839168 0.230372105420347 no 755 0.273815380567367 1281 6473636 YDL196W YDL196W
SGTC_898 1000-0849 28.3 µM 0.601069012776592 0.230458574186579 no 756 0.273897010677056 1324 6751807
SGTC_2083 5306046 65.942 µM 0.599918232371199 0.230864724552295 no 757 0.274280365404067 1335 539837
SGTC_2859 9028643 45.46 µM 0.599161731219302 0.231131937673113 no 758 0.274532519757224 1291 17151580
SGTC_1043 0916-0009 19.3 µM 0.598811099702339 0.23125584707552 no 759 0.274649429822149 1390 3101130
SGTC_745 0469-0705 296 µM 0.597410252821669 0.231751260867916 no 760 0.27511675506709 1430 3486736
SGTC_1404 3909-7820 48.3 µM 0.597315198405629 0.231784898562848 no 761 0.275148479587031 1326 23741373
SGTC_1741 st038134 10.228 µM 0.59553666984188 0.232414782543919 no 762 0.275742397482253 1440 1272587
SGTC_1376 2910-0861 41.3 µM 0.595314139218857 0.232493660986396 no 763 0.275816753193302 1382 1112859
SGTC_1616 st002734 56.1 µM 0.594785276699428 0.232681181877262 no 764 0.275993505241394 1346 4026101
SGTC_591 4299-0174 154 µM 0.594203573817575 0.232887535634765 no 765 0.276187981375547 1348 5509088
SGTC_2816 7982706 58.44 µM 0.593282343637292 0.233214541474699 no 766 0.276496106522805 1342 2981853
SGTC_2985 9022375 71.43 µM 0.592862832876468 0.23336353814772 no 767 0.276636476705026 1360 4939335
SGTC_368 fentichlor 4.58 µM 0.592109709474494 0.233631155726693 no 768 0.276888562769655 1317 7329 A pesticide.
SGTC_1618 st003135 44.5 µM 0.590975530334163 0.234034499917822 no 769 0.277268408250343 1311 1270615
SGTC_1399 3562-5772 25 µM 0.590917177728761 0.234055262079312 no 770 0.277287957886572 1310 23847490
SGTC_3186 9110464 49.47 µM 0.590381612946626 0.234245866463925 no 771 0.277467417459574 1380 17018021
SGTC_779 1360-0071 233 µM 0.589251993781588 0.234648172947966 no 772 0.277846121625017 1483 7566
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.587026825826094 0.23544176844396 no 773 0.278592845167715 1323 688662
SGTC_2199 6590217 200 µM 0.586911333788949 0.235482998520618 no 774 0.278631628737633 1350 703109
SGTC_2549 cedrol 20.94 µM 0.585781384904006 0.235886594692803 no 775 0.279011217355388 1397 6708665 A sedative which affects the nervous system.
SGTC_2770 toltrazuril 17.5 µM 0.58574443850504 0.235899797675612 no 776 0.279023633164117 1342 68591 Kills coccidiodes.
SGTC_1970 st070122 35.8 µM 0.585490133987905 0.235990685732923 no 777 0.279109099289008 1404 102928
SGTC_2678 equilin 100 µM 0.58420030646475 0.236451965192822 no 778 0.279542777686937 1431 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3090 9117696 49.47 µM 0.582884379277585 0.236923089625369 no 779 0.279985568462122 1419 7923821
SGTC_742 0kpi-0133 140 µM 0.582882796312858 0.236923656664383 no 780 0.279986101311934 1427 2728852
SGTC_3081 9117243 49.47 µM 0.582432856051298 0.237084861488587 no 781 0.28013757792016 1440 45595589
SGTC_1198 1612-1005 86.7 µM 0.582301530210562 0.237131924337716 no 782 0.280181797481758 1434 6998509
SGTC_2361 9034121 116 µM 0.580708057899969 0.237703381045759 no 783 0.280718615011568 1369 6496917
SGTC_511 blebbistatin 171 µM 0.580022867297347 0.237949338617915 no 784 0.280949598555661 1433 3476986 A myosin inhibitor.
SGTC_3246 9135460 32.98 µM 0.577334764161859 0.238915612300109 no 785 0.281856666855606 1363 41446951
SGTC_3180 9109287 49.47 µM 0.576676914866683 0.239152411196108 no 786 0.282078864984367 1354 18891271
SGTC_2756 carbadox 75.1 µM 0.57585899072619 0.239447009294309 no 787 0.282355248283151 1366 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_725 1497-0963 19 µM 0.573048441679078 0.240460815365723 no 788 0.283305947606779 1444 3549977
SGTC_156 3474-0145 5.642 µM 0.56991353174472 0.241594375529405 no 789 0.284368173256617 1335 2265471
SGTC_324 1315-0088 19.6 µM 0.567933772316157 0.242311733854214 no 790 0.285039969382914 1347 6787421
SGTC_2866 9034245 58.44 µM 0.567878472274634 0.242331788172877 no 791 0.285058745326317 1385 6462273
SGTC_2829 7992743 58.44 µM 0.566170982327934 0.242951444343214 no 792 0.285638776916207 1407 16462845
SGTC_2810 7959871 45.46 µM 0.566010486531558 0.243009733066493 no 793 0.285693325942248 1440 2974535
SGTC_994 3910-0338 138 µM 0.56590049675388 0.243049683425796 no 794 0.285730711934235 1487 3479481
SGTC_3337 9144342 33.5465 µM 0.565767403824602 0.243098030034269 no 795 0.28577595389706 1436 17682949
SGTC_422 cantharidin 155 µM 0.564836853250025 0.243436201986416 no 796 0.286092368889946 1331 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2814 7977482 42.97 µM 0.56364250625919 0.243870612540828 no 797 0.286498726295661 1485 6456762
SGTC_2010 4012422 159 µM 0.562236881997838 0.244382404746192 no 798 0.286977317911951 1432 952393
SGTC_1568 digitonin 820 nM 0.561937475468526 0.244491494330275 no 799 0.287079309745387 1495 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2669 eugenol 100 µM 0.561773015293546 0.244551427003742 no 800 0.287135339856863 1405 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2292 7671323 168.05 µM 0.561140581160343 0.244781972731459 no 801 0.287350852734591 1379 937504
SGTC_353 1988-1175 58.3 µM 0.561130032939089 0.244785818941537 no 802 0.287354447872294 1326 2788357
SGTC_2914 7968218 45.32 µM 0.560491552288328 0.245018689447169 no 803 0.287572100089158 1438 2977111
SGTC_12 0849-0099 9.267 µM 0.560473784816274 0.245025171410444 no 804 0.287578157972337 1401 6071388
SGTC_1173 0443-0020 122 µM 0.56043754297206 0.245038393515639 no 805 0.287590514945842 1388 5331295
SGTC_2270 7924575 90.91 µM 0.559392697584352 0.245419749246194 no 806 0.287946871990869 1493 1262135
SGTC_897 1000-0139 31.4 µM 0.55896059163582 0.245577555782777 no 807 0.288094307818015 1420 6151020
SGTC_444 curcumin 90.4 µM 0.558399445907471 0.24578256940081 no 808 0.288285825552613 1398 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1136 pergolide 1.05886 µM 0.55779814247705 0.24600235650426 no 809 0.288491115633454 1400 47811 A dopamine receptor agonist.
SGTC_193 1273-0060 1.558 µM 0.557690098949113 0.246041859509133 no 810 0.288528009908704 1312 2847393 YHR072W ERG7
SGTC_2398 5228213 48.84 µM 0.557159803968429 0.246235795929526 no 811 0.288709125162426 1461 80771 YMR134W ERG29
SGTC_1373 2887-0003 58.5 µM 0.556000022655589 0.2466602299532 no 812 0.289105419642353 1396 776948
SGTC_2217 6934799 96.0675 µM 0.554153557708981 0.247336770634048 no 813 0.289736879578507 1413 675606
SGTC_702 1488-0190 94 µM 0.554141587359642 0.247341159777441 no 814 0.289740975347158 1438 949357
SGTC_3061 glucosamine 200 µM 0.554058002917574 0.247371808673387 no 815 0.289769575314565 1380 91431 and experimental redox chemotherapeutic
SGTC_3205 9113483 49.47 µM 0.552920322451187 0.247789177204021 no 816 0.29015898543904 1495 17018033
SGTC_1824 st053723 68.6 µM 0.552814780476046 0.247827915294943 no 817 0.290195123222244 1361 675225
SGTC_3312 9133330 71.43 µM 0.550667988220891 0.248616574403563 no 818 0.29093064642635 1462 17617324
SGTC_249 wiskostatin 11.211 µM 0.549052216382625 0.249211035095853 no 819 0.291484808039545 1428 2775510 A n-wasp and actin depolymerizer.
SGTC_969 1313-0238 134 µM 0.548758597146112 0.249319142030689 no 820 0.291585563531046 1434 5212874
SGTC_2950 9072895 21.46 µM 0.548262849643729 0.249501726637288 no 821 0.291755716216235 1357 17332245
SGTC_61 0978-8327 98.565 µM 0.547971326825351 0.249609128128569 no 822 0.291855795586618 1426 6150059 YHR072W ERG7
SGTC_1421 4029-0249 71.4 µM 0.547815623175063 0.249666501808728 no 823 0.291909254979762 1496 2894095
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.547788954877262 0.249676329245467 no 824 0.291918411748005 1435 368090
SGTC_3351 9150312 21.596 µM 0.546911804283955 0.249999679274407 no 825 0.292219662781987 1413 4904905
SGTC_222 nsc-310342 10.666 µM 0.546908192351401 0.250001011225072 no 826 0.292220903573083 1424 432556
SGTC_810 3825-7150 143 µM 0.546613956157551 0.250109527584811 no 827 0.292321989453161 1486 22330411 YGL099W LSG1
SGTC_1525 8-methoxypsoralen 92.5 µM 0.546358649007705 0.250203706884432 no 828 0.292409714298194 1541 4114 Related to psoralen; DNA damaging agent.
SGTC_753 1322-0200 289 µM 0.545922626422494 0.250364593102572 no 829 0.292559562187173 1412 5403907
SGTC_2035 5154463 94.595 µM 0.545603630162589 0.250482332975804 no 830 0.292669214234482 1471 2769623
SGTC_2030 5175110 200 µM 0.543524444025626 0.251250468172728 no 831 0.293384382721174 1469 2831986
SGTC_3214 9129694 49.47 µM 0.542890188491821 0.251485035434476 no 832 0.293602705866699 1485 17158655
SGTC_2490 carminic acid 95.39 µM 0.542151681684017 0.251758303781247 no 833 0.293857009075013 1399 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2060 5238662 140 µM 0.541879536319668 0.251859044762259 no 834 0.293950747421755 1408 790130
SGTC_442 cape 100 µM 0.540299697349347 0.252444279225003 no 835 0.294495183537935 1500 5281787
SGTC_1706 st031321 9.9705 µM 0.539175556182925 0.252861141293882 no 836 0.29488286254354 1479 6103185
SGTC_409 arachidonic acid 100 µM 0.53794751919912 0.253316944543032 no 837 0.295306640394962 1437 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_882 0843-0131 351 µM 0.537149093362276 0.253613523095692 no 838 0.29558231589303 1431 5425421
SGTC_2144 5628481 200 µM 0.535532605157067 0.254214532242947 no 839 0.296140808810221 1427 2818399
SGTC_2861 9024595 19.48 µM 0.534985638841861 0.254418062899746 no 840 0.296329893973628 1404 16482810
SGTC_875 0709-0210 25.7 µM 0.534922793110422 0.254441453780935 no 841 0.296351623162721 1457 6251364
SGTC_2365 9042475 200 µM 0.533771396217141 0.254870197584824 no 842 0.296749852949569 1417 6464479
SGTC_764 1951-2361 146 µM 0.533686765093753 0.254901726451087 no 843 0.296779133696202 1380 5438930
SGTC_2248 tofa 1.1 µM 0.532856361773531 0.255211196946696 no 844 0.297066507458685 1454 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2024 5144227 134 µM 0.532725097665895 0.255260133763749 no 845 0.297111945054676 1475 3475211
SGTC_3353 9151644 39.2805 µM 0.532377011797954 0.255389928055879 no 846 0.29723245175389 1421 4909158
SGTC_2378 9074213 121.43 µM 0.532346481284769 0.255401313921645 no 847 0.297243022427941 1401 657714
SGTC_761 k216-0224 480 µM 0.531281441215406 0.255798669527985 no 848 0.297611882030017 1569 1340404
SGTC_2662 daunorubicin 22.37 µM 0.528999410748794 0.256651157115431 no 849 0.298402929324186 1391 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_292 k038-0015 474 µM 0.528698987263474 0.256763495027732 no 850 0.298507139921252 1456 46368540
SGTC_620 0109-0052 432 µM 0.526439081376753 0.257609365592926 no 851 0.299291583946366 1475 493037
SGTC_2088 5278280 127.392 µM 0.52606255883139 0.257750436445767 no 852 0.299422370865393 1467 791502
SGTC_2625 euphol 100 µM 0.525864670047459 0.257824595062722 no 853 0.299491118874612 1546 6708538 A triterpene alcohol.
SGTC_1822 st052468 42 µM 0.52568088707086 0.257893477458704 no 854 0.299554972831036 1395 2873678
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.525678402713096 0.257894408668651 no 855 0.299555836043957 1474 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2372 9071633 200 µM 0.524601464449459 0.258298240860669 no 856 0.299930134245432 1476 21321366
SGTC_2932 9016711 44.54 µM 0.524520910252386 0.258328460382129 no 857 0.299958139984627 1534 7117328
SGTC_1307 1187-1599 12.2 µM 0.524183453362342 0.258455075630109 no 858 0.300075474226135 1408 1538471
SGTC_1531 st059297 52.4 µM 0.523580232057521 0.258681486873304 no 859 0.300285266841935 1465 7566702
SGTC_2828 7998861 71.43 µM 0.523364453308388 0.258762501536196 no 860 0.300360328012734 1463 2988188
SGTC_227 fluconazole 33.516 µM 0.521921745002891 0.259304507138342 no 861 0.300862408727453 1400 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_641 4092-0595 30 µM 0.521691958623524 0.259390888837896 no 862 0.300942412225705 1486 786260
SGTC_450 aminopyrene 156 nM 0.519188200364849 0.26033306857207 no 863 0.301814753331394 1496 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2686 alizarin 95.37 µM 0.516668234854998 0.261283124292681 no 864 0.302693886993541 1425 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1889 st059080 5.18 µM 0.516323202385187 0.261413343965905 no 865 0.302814346792356 1548 176925 Isolated from Daphnopsis sellowiana.
SGTC_1799 st045822 46.1415 µM 0.516277273178629 0.26143068074996 no 866 0.302830383490376 1507 3674992
SGTC_540 1187-0821 17.3 µM 0.514851444276923 0.261969178377343 no 867 0.303328416674507 1439 847520
SGTC_686 1319-0111 510 µM 0.51462980737409 0.262052935778092 no 868 0.303405865931961 1545 4562600
SGTC_602 3130-1533 38.1 µM 0.512999852595823 0.262669323061873 no 869 0.303975711901589 1532 720941
SGTC_2441 5730946 39.09 µM 0.512686957903636 0.262787732817063 no 870 0.304085157102082 1526 1774275
SGTC_1218 1348-1416 30.7 µM 0.512129955352872 0.26299858863945 no 871 0.304280030491653 1458 6787668
SGTC_1330 1469-0054 61.8 µM 0.510203205020305 0.26372863500665 no 872 0.30495455351799 1563 7102664
SGTC_3259 9138485 49.47 µM 0.510069806783543 0.263779217874831 no 873 0.305001278583465 1557 17646153
SGTC_758 0868-0029 16 µM 0.508683563962073 0.264305155714032 no 874 0.305487022451257 1540 762687
SGTC_464 bw-b 70c 158 µM 0.50796782385613 0.264576914972115 no 875 0.305737954220367 1518 5353454
SGTC_2331 7980721 200 µM 0.507898898781841 0.264603092625404 no 876 0.305762123523239 1541 2981221
SGTC_2 0422-0095 29 µM 0.50624414879982 0.265231959779431 no 877 0.306342632825196 1365 6790840
SGTC_2998 9066762 71.4286 µM 0.50527676361663 0.265599953664642 no 878 0.306682230416749 1569 4945196
SGTC_612 0302-0167 22.4 µM 0.504723099206421 0.265810684378757 no 879 0.306876667326188 1562 235821
SGTC_792 4534-1957 155 µM 0.504394281446785 0.265935876102045 no 880 0.306992167888986 1490 1717904
SGTC_1125 tnp00248 1.32998 µM 0.502344132633224 0.266717108307466 no 881 0.307712735116776 1598 24207736
SGTC_2790 5423970 71.43 µM 0.50172577520083 0.266952967846739 no 882 0.307930215481047 1594 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2860 9025725 38.96 µM 0.501655380967424 0.266979824935837 no 883 0.307954977874185 1426 40546248
SGTC_1467 k284-1082 293 µM 0.501051255202252 0.267210369507099 no 884 0.308167525540945 1548 3334705
SGTC_515 4092-1064 102 µM 0.500682529976549 0.267351130627603 no 885 0.308297284602914 1596 717353
SGTC_628 1636-0253 16 µM 0.50029946860173 0.267497404190811 no 886 0.308432114109477 1539 4456143
SGTC_910 3454-3003 490 µM 0.499170069760388 0.267928904552867 no 887 0.30882978898608 1454 820824
SGTC_226 1,3-diallylurea 8.28947 mM 0.498341983524507 0.268245507401858 no 888 0.30912151059601 1481 74537 YKL182W FAS1
SGTC_2840 9008771 71.43 µM 0.496219754066495 0.269057759419342 no 889 0.309869687640553 1586 2992978
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.495252719585445 0.269428286542625 no 890 0.310210870432944 1450 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2709 st078560 56 µM 0.494186428824595 0.269837140823478 no 891 0.310587261633213 1603 17250903
SGTC_115 0527-0192 112.043 µM 0.49277304105371 0.270379562929578 no 892 0.311086480722151 1500 4233931
SGTC_1614 st002383 48.6 µM 0.491957462066851 0.270692809087755 no 893 0.311374707602695 1494 1947235
SGTC_1119 parthenolide 318.541 nM 0.490921142538887 0.271091098138532 no 894 0.31174111137886 1602 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2207 7258803 200 µM 0.490851524301063 0.271117865013396 no 895 0.311765732467591 1526 3666799
SGTC_1954 st077032 68.9 µM 0.490234285323587 0.271355239169288 no 896 0.311984061130308 1410 698907
SGTC_953 1188-0045 9.7 µM 0.48965149734526 0.271579459377205 no 897 0.312190264494023 1552 6144426
SGTC_321 4534-3890 65.3 µM 0.489492133934693 0.271640788467395 no 898 0.312246661066215 1537 699746
SGTC_143 4032-1194 15.74 µM 0.489409675773614 0.271672524204799 no 899 0.312275843629954 1503 1806963
SGTC_2127 5253358 187.912 µM 0.487817606794281 0.272285626663424 no 900 0.312839519526814 1446 20612
SGTC_2226 7298446 200 µM 0.487285735192397 0.272490602406794 no 901 0.313027927607481 1558 3283010
SGTC_1701 st028638 40.4 µM 0.486063626687755 0.27296187573081 no 902 0.313461027424283 1582 3490878
SGTC_727 3032-0951 202 µM 0.484538618156526 0.273550520543576 no 903 0.314001832054389 1529 3652836
SGTC_116 0155-0182 31.788 µM 0.483063099101171 0.27412066005314 no 904 0.314525467051244 1486 771486
SGTC_1141 3253-0389 52.6 µM 0.481647056993028 0.274668369172612 no 905 0.315028345859509 1514 5402031
SGTC_2318 6029776 164 µM 0.481144850526659 0.274862746534591 no 906 0.315206776819796 1588 818325
SGTC_2738 aclarubicin 5.55 µM 0.480705379018918 0.275032898140994 no 907 0.315362953801738 1536 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1471 k673-0312 37 µM 0.480641165072158 0.275057764406547 no 908 0.315385776566579 1500 24099884
SGTC_1994 st072947 40.9 µM 0.479516451449037 0.275493478975807 no 909 0.315785633701325 1538 5286565 YDL195W SEC31
SGTC_1226 3909-7979 35.4 µM 0.478583658234223 0.275855100850073 no 910 0.316117423125419 1588 6615510
SGTC_1360 1598-0022 39.8 µM 0.477439954890124 0.276298805629075 no 911 0.316524434285272 1597 761525
SGTC_1746 st038117 42 µM 0.47684051627791 0.276531500265611 no 912 0.316737846083433 1528 2898218
SGTC_784 4579-0127 173 µM 0.476350689925132 0.276721716085093 no 913 0.316912279084667 1647 1948547
SGTC_2311 7694451 200 µM 0.47603247808539 0.27684532263867 no 914 0.317025619926124 1581 2163142
SGTC_336 4111-0029 111 µM 0.47532209170067 0.277121363428646 no 915 0.317278707617951 1482 3131175
SGTC_2380 9035439 200 µM 0.474233930525602 0.277544460320881 no 916 0.317666549952954 1587 6462575
SGTC_3056 9094900 49.47 µM 0.472648977730131 0.278161283017081 no 917 0.318231816782402 1440 25236784
SGTC_128 0906-2981 13.371 µM 0.471502796328268 0.278607763379521 no 918 0.318640861620557 1581 6740226
SGTC_2439 5492030 7.2 µM 0.469071859773764 0.279555857210864 no 919 0.319509136256109 1572 5722370
SGTC_305 1682-2595 20.8 µM 0.468273239644816 0.279867669922193 no 920 0.319794601380743 1558 226033
SGTC_3087 9117406 49.47 µM 0.467957418752083 0.279991025347727 no 921 0.31990752037996 1508 42546093
SGTC_2223 6903751 107.57 µM 0.46775057064037 0.280071831742753 no 922 0.319981486159627 1538 5598863
SGTC_1979 st071809 45.3 µM 0.467063712898654 0.280340237693917 no 923 0.320227147502476 1593 4976333
SGTC_598 3937-0236 20.2 µM 0.466230305068348 0.280666078741407 no 924 0.320525329742478 1568 1379313
SGTC_63 0099-0242 26.702 µM 0.46609428772678 0.280719275412373 no 925 0.320574005942857 1534 3898502 YLR359W ADE13
SGTC_964 1287-0107 19.4 µM 0.465560443153706 0.280928110275889 no 926 0.320765081440437 1641 51516812 YPR165W RHO1
SGTC_1710 st031758 61.5 µM 0.465061983514858 0.281123170657524 no 927 0.320943534718066 1608 5394341
SGTC_3129 9127257 49.47 µM 0.464380856674191 0.281389819253119 no 928 0.321187451472757 1418 837894
SGTC_1571 st070080 73.4 µM 0.463697455030943 0.28165748100367 no 929 0.321432260402246 1636 4315245
SGTC_2737 bleomycin 30.5 nM 0.462977020795605 0.281939779831074 no 930 0.321690419198939 1541 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_145 3737-0113 38.366 µM 0.462728137570305 0.282037335240644 no 931 0.321779623479029 1624 6849351
SGTC_2375 9072683 200 µM 0.462331597011131 0.282192801857137 no 932 0.32192177205943 1672 16798029
SGTC_2093 5331342 194.4 µM 0.462246613683856 0.282226125556551 no 933 0.321952239571736 1596 33839
SGTC_1403 3909-7815 62.9 µM 0.461851517972876 0.282381075524246 no 934 0.322093901698574 1583 6615483
SGTC_1295 1013-0063 9.78 µM 0.46177334500211 0.282411738512146 no 935 0.322121933792098 1636 6826038
SGTC_1400 3771-8998 51.5 µM 0.461658182520365 0.282456913382672 no 936 0.322163231820445 1575 670767
SGTC_505 gw-5074 63.9 µM 0.459207319808726 0.283419138103751 no 937 0.323042647317729 1622 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1077 5-fluorocytosine 377 nM 0.457655222836694 0.284029313084126 no 938 0.323600081229848 1544 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_848 0368-0089 85.6 µM 0.457017024575151 0.284280389802489 no 939 0.323829404410573 1576 762535
SGTC_2176 5809774 33.9695 µM 0.45651513133917 0.28447791658437 no 940 0.324009796228828 1617 2870539
SGTC_209 4077-0173 175.592 µM 0.456346742351128 0.284544203003444 no 941 0.324070328314964 1536 15993494
SGTC_1916 st067606 49.2 µM 0.45398877052276 0.285473193929427 no 942 0.324918454623667 1648 19590279
SGTC_2186 6124449 200 µM 0.452384489361193 0.286106071036777 no 943 0.325496009453676 1583 3834182 YLR033W RSC58
SGTC_1866 st057638 64 µM 0.452074425559762 0.286228465746297 no 944 0.3256076834422 1554 688802
SGTC_876 0720-0963 56.8 µM 0.45113006654342 0.286601395519392 no 945 0.325947904491263 1677 765861
SGTC_3314 9135860 59.4275 µM 0.451049856992987 0.286633081089849 no 946 0.325976807999507 1579 25252478
SGTC_106 0092-0003 11.579 µM 0.4498505444935 0.287107049377493 no 947 0.326409104839483 1652 1072148
SGTC_2322 7413319 38.22 µM 0.44928383997699 0.28733114002619 no 948 0.326613456872556 1589 1840400
SGTC_2523 spermine 47.74 µM 0.448663171752494 0.287576664324797 no 949 0.326837327768564 1661 1103 A DNA binding polyamine.
SGTC_75 0159-0059 199.013 µM 0.448419749658729 0.287672984447896 no 950 0.326925145522734 1650 5377270
SGTC_1506 4226-2149 212 µM 0.448095721902768 0.287801223218876 no 951 0.327042057713076 1597 991114
SGTC_3323 9138564 53.9225 µM 0.444229696915754 0.289333338835252 no 952 0.328438261859595 1677 43912313 YNL103W MET4
SGTC_3038 9091290 49.47 µM 0.443674365051307 0.289553732702776 no 953 0.328639015932803 1604 25236843
SGTC_3142 9086498 49.47 µM 0.44332409752135 0.289692783469941 no 954 0.328765664100947 1574 25236367
SGTC_2580 diallyl disulphide 81.36 µM 0.442934095190589 0.28984764519934 no 955 0.328906702541196 1567 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2121 5257820 149.641 µM 0.442381054708584 0.290067312503778 no 956 0.329106743031066 1664 791256
SGTC_2834 9001755 58.44 µM 0.441858234137252 0.290275048205085 no 957 0.329295897673983 1588 2989575
SGTC_1951 sophoraflavanone G 9.2 µM 0.440617136091394 0.290768460612519 no 958 0.32974509750889 1536 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1261 0712-0010 12.7 µM 0.439208971677304 0.291328766559676 no 959 0.330255062436492 1677 2840123
SGTC_2847 9005661 71.43 µM 0.439122787838181 0.291363075302368 no 960 0.330286284056709 1552 2991449
SGTC_829 1635-0120 117 µM 0.437592424259605 0.291972608240535 no 961 0.330840881937366 1681 285054
SGTC_2237 6667747 47.222 µM 0.436973397620563 0.29221933069789 no 962 0.331065320406301 1560 729940 YDL015C TSC13
SGTC_1539 benzyladenosine 56 µM 0.436622707989149 0.292359146395649 no 963 0.331192495748884 1535 92208 A nucleotide analog.
SGTC_862 0452-0056 10.2 µM 0.43653051039564 0.292395909620122 no 964 0.331225933847536 1546 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2139 5578692 56.4705 µM 0.436405712924355 0.29244567526918 no 965 0.331271197369507 1669 650991 YMR113W FOL3
SGTC_2156 5649887 115 µM 0.435888009969043 0.292652162380404 no 966 0.331458992389312 1659 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2506 ethyl hematommate 54.16 µM 0.435141986866578 0.292949834606432 no 967 0.331729684312458 1495 3940691 An allergen.
SGTC_426 0988-0037 14.6 µM 0.434351037597291 0.293265586277171 no 968 0.332016773524701 1617 5383008
SGTC_841 0251-0215 91.2 µM 0.433389185911809 0.293649775635122 no 969 0.332366027738817 1613 3888614
SGTC_1976 st070609 63.5 µM 0.432535253191167 0.293991054374202 no 970 0.332676217954897 1537 682556
SGTC_3231 9132313 49.47 µM 0.432255591800803 0.294102862381076 no 971 0.332777829596844 1606 4905967
SGTC_1434 4073-0095 163 µM 0.431626156841337 0.294354580952575 no 972 0.333006572235092 1589 24133745
SGTC_3164 9100705 49.47 µM 0.430122731828311 0.294956220821028 no 973 0.333553182538304 1649 17174235
SGTC_2281 7943571 200 µM 0.429824234694877 0.295075740638325 no 974 0.333661751242955 1690 1244024
SGTC_657 3534-0529 86.7 µM 0.428934834779873 0.295431993206186 no 975 0.333985324335055 1677 1049549
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.428090937238076 0.295770202431765 no 976 0.334292457337683 1607 688788
SGTC_1101 ebselen 5.29 µM 0.428006463121306 0.295804066956457 no 977 0.334323207454671 1721 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_435 c-PAF 6.7 µM 0.427500070606114 0.296007110162124 no 978 0.334507566855843 1583 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2848 9016370 25.97 µM 0.426635563155196 0.296353890937821 no 979 0.334822395311438 1709 7894410
SGTC_168 3970-0862 530.542 µM 0.426044139288215 0.296591236657764 no 980 0.335037841588449 1598 3135186
SGTC_439 amiodarone 34.4 µM 0.424643323550206 0.297153748434316 no 981 0.335548352887581 1660 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_619 1652-1634 108 µM 0.424553568204493 0.297189807224996 no 982 0.335581073562357 1573 5400454
SGTC_2781 5567276 71.43 µM 0.421826456334365 0.298286363923644 no 983 0.336575846715447 1646 2853274
SGTC_1645 Cervolide 78 µM 0.420925830100364 0.298648905002762 no 984 0.336904621459874 1582 23173 A fragrance.
SGTC_2229 7354935 190 µM 0.419895143578157 0.299064046652083 no 985 0.337281027828439 1625 318112
SGTC_568 1193-0097 7.48 µM 0.417952038747813 0.299847405365454 no 986 0.337991091930262 1578 3646150
SGTC_1521 st012942 49.4 µM 0.41621940708691 0.300546694680179 no 987 0.33862472994472 1776 24207259
SGTC_608 k048-0125 159 µM 0.415880388922295 0.300683608349492 no 988 0.338748765268335 1678 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_472 calcifediol 10 µM 0.415139643411685 0.300982858914099 no 989 0.339019839929922 1621 5283731 A vitamin D metabolite.
SGTC_788 1182-0090 188 µM 0.414015690792493 0.301437175893771 no 990 0.339431307816843 1764 5715185
SGTC_3 0833-0587 95.581 µM 0.413936458868853 0.301469214160999 no 991 0.33946032106809 1593 5382644
SGTC_135 0933-0004 26.348 µM 0.412721488646072 0.301960692025873 no 992 0.339905339563045 1551 21230617 YGL099W LSG1
SGTC_1035 k081-0041 55.2 µM 0.412679351761434 0.301977743629159 no 993 0.339920777441434 1692 731709
SGTC_1570 verbenone 133 µM 0.412535848868114 0.30203581842849 no 994 0.339973355250385 1723 29025 A natural terpanoid with antifungal properties.
SGTC_3144 9087057 49.47 µM 0.411577179830808 0.302423914905204 no 995 0.340324680366859 1767 17249618
SGTC_824 1304-0008 100 µM 0.410585235679378 0.302825717330191 no 996 0.340688345819832 1621 768245
SGTC_1867 st057372 64 µM 0.409098861829243 0.303428243208335 no 997 0.341233555749688 1605 688837
SGTC_1289 0976-0073 69.1 µM 0.408972966903701 0.303479301364505 no 998 0.34127974993409 1639 3391136
SGTC_2651 TUB2.036 5 µM 0.408769446688831 0.30356184947818 no 999 0.341354431924393 1685 15992207 YFL037W TUB2
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.403700240487981 0.305621153176311 no 1000 0.34321658136953 1593 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1980 st071811 45.7 µM 0.402353269523958 0.306169383020629 no 1001 0.34371202805027 1692 4974850
SGTC_1075 aripiprazole 15.2 µM 0.402299153368839 0.306191417888251 no 1002 0.343731938825094 1609 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2697 mebhydrolin 72.4 µM 0.402001659090267 0.306312563312464 no 1003 0.343841402633983 1764 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1761 st044296 37 µM 0.400441580370841 0.306948204020064 no 1004 0.344415651891026 1584 1826700
SGTC_1687 st020778 55.3625 µM 0.400375334512381 0.306975208194413 no 1005 0.344440044274951 1655 4259299
SGTC_1956 st077085 54 µM 0.400349631112713 0.306985686098738 no 1006 0.344449508696555 1603 24208685
SGTC_1216 1165-0504 9.65 µM 0.400255919230929 0.307023888766875 no 1007 0.344484015803404 1720 6304004
SGTC_1022 4477-0945 21.3 µM 0.398074439387357 0.307913784114733 no 1008 0.345287657591519 1599 4648966
SGTC_3265 9137266 49.47 µM 0.397494993680403 0.308150348836005 no 1009 0.345501238790528 1778 17224265
SGTC_1062 mesoridazine 14.2 µM 0.39747912965884 0.308156826608965 no 1010 0.345507086892943 1627 4078 A neuroleptic.
SGTC_2044 5102272 200 µM 0.395594132831139 0.308926954310658 no 1011 0.346202233041415 1618 592666
SGTC_2595 hexamethylquercetagetin 100 µM 0.394626592527183 0.309322575946394 no 1012 0.346559242550102 1637 386331
SGTC_104 0074-0074 590.992 µM 0.393503508421063 0.309782075880156 no 1013 0.346973816612074 1679 3943124
SGTC_561 1550-0330 72.9 µM 0.393249733827977 0.309885946726995 no 1014 0.347067520091827 1599 6812934
SGTC_1776 st049249 45.9 µM 0.392279723046086 0.310283115434506 no 1015 0.347425772057825 1582 1822314
SGTC_2129 girgensonine 121.053 µM 0.391460483982113 0.310618723463176 no 1016 0.347728446049973 1709 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_944 3370-0224 231 µM 0.391167175128573 0.31073891819556 no 1017 0.347836834807268 1591 4580514
SGTC_1464 k208-0027 110 µM 0.390696573856057 0.310931807609576 no 1018 0.348010765825567 1735 X1464
SGTC_1024 4507-0395 26 µM 0.390513736694504 0.311006762676424 no 1019 0.348078349821001 1661 4201836
SGTC_2568 diosmetin 100 µM 0.389778357230221 0.311308314560871 no 1020 0.348350224473217 1704 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1603 st002045 67.8 µM 0.388249882290511 0.311935490601065 no 1021 0.348915560977887 1737 5887985
SGTC_2920 7982904 15.77 µM 0.387629938432099 0.312190026564555 no 1022 0.349144955124697 1606 6456808
SGTC_935 2996-0153 430 µM 0.387323260614728 0.312315975213683 no 1023 0.349258453684467 1789 23738523
SGTC_823 0417-1665 178 µM 0.386758852443323 0.312547827735809 no 1024 0.349467371043763 1670 3429856
SGTC_2385 9074692 200 µM 0.386713920814559 0.31256628833325 no 1025 0.349484004580187 1611 17046906
SGTC_534 k292-0788 63.4 µM 0.386619175872589 0.312605216757113 no 1026 0.349519079783284 1814 4146317
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.386364377082052 0.312709917838923 no 1027 0.349613414351057 1739 165506
SGTC_2518 prenyletin 46.28 µM 0.385935711208887 0.312886097911017 no 1028 0.349772140962435 1732 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.385830281742695 0.312929435578447 no 1029 0.349811183462004 1784 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2916 7875993 68.79 µM 0.384815651912097 0.313346639775851 no 1030 0.350187000965277 1801 1299250
SGTC_990 3985-0011 41.3 µM 0.384686841665666 0.313399622183615 no 1031 0.350234722610288 1642 5399565 YGL099W LSG1
SGTC_2891 9063876 19.48 µM 0.384462883535054 0.313491750117952 no 1032 0.350317700291454 1746 6472478
SGTC_1796 st049173 110.4 µM 0.384446189199492 0.31349861800452 no 1033 0.350323885917962 1707 94134
SGTC_2190 6049624 200 µM 0.384295631917921 0.313560558720114 no 1034 0.350379672567645 1701 2265554
SGTC_487 nimodipine 119 µM 0.383933383705642 0.313709612662746 no 1035 0.350513911210217 1719 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3235 9132602 49.47 µM 0.383359227864541 0.313945922343788 no 1036 0.350726714894517 1678 4912240
SGTC_3219 9131112 49.47 µM 0.383183856994602 0.314018116285739 no 1037 0.350791723257074 1656 17612988 YMR079W SEC14
SGTC_2451 5856223 45.7 µM 0.382176362624407 0.314433003689159 no 1038 0.351165276708303 1598 2179896
SGTC_1168 k815-0004 80.5 µM 0.381051528332092 0.314896488863424 no 1039 0.351582506791596 1622 642433
SGTC_895 0964-0006 13.7 µM 0.378137592139179 0.316098524197213 no 1040 0.352664191736649 1721 6738897
SGTC_42 0133-0086 60.653 µM 0.375951445504214 0.317001616106168 no 1041 0.353476496632345 1553 162923 Model of phenazepam hydroxylation.
SGTC_1304 1165-0502 251 µM 0.375353886298739 0.317248656502867 no 1042 0.353698647638574 1684 767425
SGTC_1640 st009078 66.4 µM 0.374078060945587 0.317776375309796 no 1043 0.354173120281576 1738 690618
SGTC_642 0335-0876 158 µM 0.373817047258923 0.317884383901453 no 1044 0.354270217810191 1678 6812350
SGTC_826 1683-5028 118 µM 0.372943271726466 0.318246068713463 no 1045 0.354595332685539 1671 722377
SGTC_700 3453-2283 142 µM 0.372558082361571 0.318405566503406 no 1046 0.354738687818386 1737 565664
SGTC_7 0192-1582 4.227 µM 0.37241694971302 0.318464014618091 no 1047 0.354791218016651 1695 252616
SGTC_449 xestospongin c 11.1929 µM 0.371644675833986 0.318783921031492 no 1048 0.355078710649563 1723 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3158 9100007 49.47 µM 0.371506054271322 0.318841357876863 no 1049 0.355130323722381 1616 19297233
SGTC_468 gf-109203x 121 µM 0.370911621481623 0.319087706142123 no 1050 0.355351679466602 1762 2396 A protein kinase C inhibitor.
SGTC_754 3474-0146 171 µM 0.370327530350033 0.319329846409011 no 1051 0.355569231713521 1570 24762078
SGTC_3107 9121808 49.47 µM 0.369923470916342 0.319497398015681 no 1052 0.355719756384579 1764 662681
SGTC_3181 9108277 49.47 µM 0.368900983224388 0.319921558283109 no 1053 0.356100765226904 1636 17097298
SGTC_3293 9120939 62.045 µM 0.368667707284936 0.320018361547035 no 1054 0.356187710820366 1721 934087
SGTC_896 0964-0007 44.5 µM 0.367247470320852 0.320607986069193 no 1055 0.356717216564571 1768 6756758
SGTC_3025 9087895 49.47 µM 0.362405817153357 0.322621440180815 no 1056 0.358524396540622 1780 17173641
SGTC_812 4251-0442 148 µM 0.361713131048153 0.322909928808043 no 1057 0.358783206712008 1785 5723007
SGTC_1793 st048256 72.231 µM 0.361020855608583 0.323198352900582 no 1058 0.359041928241606 1674 672022
SGTC_1907 st060210 83.7 µM 0.359261404096744 0.323931874835668 no 1059 0.359699772317353 1773 688793
SGTC_3345 9148410 3.559 µM 0.357690429101912 0.324587398592615 no 1060 0.360287498172947 1780 4903596
SGTC_337 1315-0038 354 µM 0.357358520958518 0.324725964190487 no 1061 0.36041171241606 1687 1626437
SGTC_2702 st077768 96.8 µM 0.357320591820916 0.32474180045873 no 1062 0.360425908062181 1647 6484119
SGTC_2708 st078559 56 µM 0.356203691523432 0.325208273369117 no 1063 0.36084401379274 1678 17250902
SGTC_49 0717-0965 32.132 µM 0.355347338378672 0.325566114539335 no 1064 0.361164697780026 1772 5889349 YGL099W LSG1
SGTC_1797 st048695 56.8 µM 0.354801283664073 0.325794376429648 no 1065 0.361369233320693 1792 592262 YIL048W NEO1
SGTC_1636 st007707 68.9 µM 0.354164524441303 0.326060637130713 no 1066 0.361607794068403 1818 403051
SGTC_3128 9127691 49.47 µM 0.354037191895799 0.326113891848276 no 1067 0.361655505445838 1707 41316314
SGTC_1260 0700-1617 7.75 µM 0.35393609001761 0.326156178551773 no 1068 0.361693389750407 1722 2853078
SGTC_791 1348-1292 225 µM 0.353615721454622 0.326290190136482 no 1069 0.361813445337305 1796 5437054
SGTC_2324 6149169 200 µM 0.35321776030618 0.326456690278182 no 1070 0.361962597073008 1771 2888231
SGTC_218 alverine citrate 93.75 µM 0.35318933422186 0.326468584589635 no 1071 0.361973251678929 1764 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.35077035603817 0.327481401643339 no 1072 0.362880319152465 1734 6708739 YPR165W RHO1
SGTC_2080 5212524 12.4 µM 0.349370504352599 0.328068095404715 no 1073 0.363405586997345 1843 260183
SGTC_1132 3456-3614 2.5 µM 0.349142454769339 0.328163713822683 no 1074 0.363491182650109 1886 3125502
SGTC_3100 9120536 49.47 µM 0.347888236727827 0.328689793328522 no 1075 0.363962059935257 1799 16421196
SGTC_491 tetrandrine 80.3 µM 0.34761935207705 0.328802620764936 no 1076 0.36406303540298 1803 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3236 9132701 49.47 µM 0.346633440070225 0.329216455486148 no 1077 0.364433360096843 1671 24282524
SGTC_2973 9094665 17.96 µM 0.345994750605317 0.329484655967551 no 1078 0.364673329899069 1830 25237061 YIL048W NEO1
SGTC_2107 5363541 170.161 µM 0.345249210727995 0.329797836391129 no 1079 0.364953512852002 1725 244052
SGTC_438 sphingosine 6.67 µM 0.344012222236199 0.330317723856157 no 1080 0.36541854722081 1540 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2995 9067767 71.4286 µM 0.343981749376929 0.330330535275794 no 1081 0.365430005710708 1723 11673567
SGTC_311 1315-0136 58 µM 0.343974092121259 0.330333754575553 no 1082 0.365432885032317 1789 6759207
SGTC_34 0469-0683 81.75 µM 0.343573703213619 0.330502105470611 no 1083 0.365583451940555 1783 3690923
SGTC_229 benomyl 22.8748 µM 0.343442737510699 0.330557179861242 no 1084 0.365632706305725 1694 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_821 1114-0266 29.2 µM 0.343358691452872 0.33059252528741 no 1085 0.365664316017159 1689 3123235
SGTC_1874 staurosporine 7.6 µM 0.341333173674556 0.331444809681093 no 1086 0.366426388434434 1788 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3282 9108498 15.4605 µM 0.338647000100115 0.332576427643158 no 1087 0.367437835748393 1687 16459645
SGTC_2771 fluoxetine 41.05 µM 0.337054235823598 0.333248141604629 no 1088 0.368038007686409 1790 3386 A selective serotonin reuptake inhibitor.
SGTC_1806 st050005 60.3 µM 0.33499777988701 0.334116198947665 no 1089 0.368813380476006 1694 5194765
SGTC_1627 st003713 25.6 µM 0.334441692513652 0.334351083550853 no 1090 0.369023141359657 1696 16195070 YER133W GLC7
SGTC_2608 thymoquinone 42.66 µM 0.3339702047741 0.334550285110494 no 1091 0.369201021107697 1729 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1553 gossypol 38.6 µM 0.333940089322214 0.334563010343864 no 1092 0.369212383816528 1726 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_737 1950-0117 57.9 µM 0.333836649893495 0.334606719947269 no 1093 0.369251412894461 1833 5393513
SGTC_1579 chlormadinone acetate 49.4 µM 0.333649156856502 0.334685953150686 no 1094 0.36932215995662 1850 45114258 A steroidal progestin.
SGTC_2514 salinomycin 42.74 µM 0.332668228836953 0.335100606186097 no 1095 0.369692367270367 1882 23682228 A polyether potassium ionophore.
SGTC_1455 4262-0120 131 µM 0.332255109862442 0.335275297988979 no 1096 0.369848316687423 1811 1529587
SGTC_257 daunorubicin 18.5 µM 0.331024125578244 0.335796044064411 no 1097 0.370313131164519 1860 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_536 3852-0578 10.6 µM 0.330458530616907 0.336035414811971 no 1098 0.370526760993876 1836 2869208
SGTC_533 1222-0222 6.71 µM 0.329670318763829 0.336369112260773 no 1099 0.370824541626804 1843 3982874
SGTC_496 calpeptin 138 µM 0.328216273611072 0.336985035145203 no 1100 0.371374072113972 1700 73364 A calpain inhibitor.
SGTC_2778 tioconazole 65.09 nM 0.32787415239181 0.337130018806056 no 1101 0.371503408900183 1683 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2125 5246583 200 µM 0.327856403695904 0.337137540984379 no 1102 0.371510119079602 1895 835267
SGTC_1081 sertraline 6 µM 0.327839030367375 0.337144904139129 no 1103 0.371516687383174 1835 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1006 4099-6547 255 µM 0.327584505059824 0.337252784069017 no 1104 0.371612919603707 1788 3146833
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.327466868892074 0.337302648393795 no 1105 0.371657398794872 1847 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1625 st003711 30.1 µM 0.327118657598764 0.337450267034016 no 1106 0.371789070355656 1814 24207034 YER133W GLC7
SGTC_2296 7971656 126.45 µM 0.326691282482156 0.337631480116619 no 1107 0.371950697184291 1698 666570
SGTC_2468 5987765 72.9 µM 0.326649513372174 0.337649192829394 no 1108 0.371966494843267 1785 26772094
SGTC_2895 9054447 58.44 µM 0.326649037206476 0.337649394755479 no 1109 0.371966674937007 1735 2697450
SGTC_1275 0867-0008 21.1 µM 0.326397612417635 0.337756022198745 no 1110 0.372061771860433 1768 3422836
SGTC_1396 3511-0007 98.6 µM 0.325898283667445 0.337967822535902 no 1111 0.372250657152844 1742 X1396
SGTC_1156 4092-0367 4.88 µM 0.325732152632382 0.338038301735369 no 1112 0.372313507756041 1757 1357585
SGTC_1129 3453-1384 223 µM 0.324398054688381 0.338604483264538 no 1113 0.372818346159408 1769 1084452
SGTC_147 4466-0538 29.23 µM 0.324393064145126 0.338606601900979 no 1114 0.372820235050626 1769 6742687 YHR072W ERG7
SGTC_425 3825-7017 13.1 µM 0.323559050776758 0.338960737485548 no 1115 0.373135947121279 1797 3397440
SGTC_2543 pimpinellin 60.67 µM 0.321212447555799 0.339957906154906 no 1116 0.374024699892448 1700 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2999 9069765 71.4286 µM 0.321178965949246 0.339972141998564 no 1117 0.374037385579519 1802 2097066
SGTC_2469 5655019 90.81 µM 0.320800622051561 0.340133023626758 no 1118 0.374180743981429 1860 2788239
SGTC_3140 9094243 49.47 µM 0.320229139842794 0.340376087856387 no 1119 0.374397317466349 1907 19291112
SGTC_1523 st012844 44.7 µM 0.318884490835177 0.340948258791695 no 1120 0.37490705268773 1745 4274103
SGTC_685 1278-0033 54.9 µM 0.31823586668798 0.341224390305089 no 1121 0.375153014079649 1834 3590572
SGTC_199 4063-0024 41.6 µM 0.318024126548094 0.341314550489227 no 1122 0.37523331795537 1837 306215
SGTC_1860 st056228 74.6 µM 0.317853147659381 0.34138736090623 no 1123 0.375298166798296 1714 688679
SGTC_264 promethazine 12.5 mM 0.317496935301337 0.341539070935819 no 1124 0.375433282276976 1852 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_501 nsc-95397 161 µM 0.316138194220345 0.342117990582101 no 1125 0.375948808714427 1836 262093
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.316087750369445 0.34213949038122 no 1126 0.375967952126042 1772 4000243
SGTC_1632 st005650 90 µM 0.315426064382247 0.342421556572909 no 1127 0.376219089812891 1757 2759605
SGTC_806 3966-4455 5.86 µM 0.314494183752769 0.342818951501182 no 1128 0.376572866618213 1693 714982
SGTC_2809 7964133 12.99 µM 0.31446141167248 0.342832930128357 no 1129 0.376585310017024 1779 1253665
SGTC_1498 4478-3555 97.6 µM 0.313769626943229 0.343128054677208 no 1130 0.376848007204762 1881 3437919
SGTC_1405 3909-7894 12 µM 0.313656613037918 0.343176277009419 no 1131 0.376890928340213 1852 7104060
SGTC_1480 1070-0044 41.2 µM 0.313572663829792 0.343212099268823 no 1132 0.3769228120861 1841 3124987
SGTC_3157 9099274 49.47 µM 0.312945764630119 0.343479650137338 no 1133 0.377160933704781 1902 17217662
SGTC_13 0199-0087 65 µM 0.312706844105727 0.343581638369118 no 1134 0.377251697663736 1803 4589825
SGTC_56 0957-0365 83.25 µM 0.311480353591692 0.344105370679862 no 1135 0.377717738066927 1836 6752360
SGTC_1813 st051246 8.6015 µM 0.311315644090639 0.344175727246945 no 1136 0.377780337763529 1881 5291959
SGTC_278 4092-0821 23.9 µM 0.311249152499525 0.344204131023302 no 1137 0.377805609549417 1825 877900
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.311210608024785 0.344220596795587 no 1138 0.377820259576881 1723 4174840
SGTC_2143 5623677 140.463 µM 0.311064772793756 0.344282898661693 no 1139 0.377875690386231 1838 5375313
SGTC_3318 9139014 38.6185 µM 0.310934684075045 0.34433847707005 no 1140 0.377925138193759 1769 16643984
SGTC_2430 5571206 200 µM 0.309848332879985 0.344802735093322 no 1141 0.378338147369639 1918 1731771
SGTC_1057 3448-5381 134 µM 0.308512493394308 0.345373933733674 no 1142 0.378846197607971 1871 5497911
SGTC_2533 agelasine 13.65 µM 0.306523170764085 0.346225211438953 no 1143 0.379603170302328 1937 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1102 cgs 12066b 26.1 µM 0.306336570110018 0.346305102177951 no 1144 0.379674198903286 1791 6438352 A 5-HT1B full agonist.
SGTC_733 4069-0007 56.1 µM 0.306245731758438 0.34634399595863 no 1145 0.379708777534717 1805 5717425 YNL287W SEC21
SGTC_3024 9090631 49.47 µM 0.305746748385124 0.346557671940264 no 1146 0.379898738267855 1917 25236383
SGTC_2705 st078069 42.8 µM 0.305612642748536 0.3466151073393 no 1147 0.379949796625704 1757 1530061
SGTC_53 0973-0023 39.979 µM 0.30530960030983 0.346744908779131 no 1148 0.380065182399874 1947 674768
SGTC_1111 tnp00062 510.699 nM 0.304844949615268 0.346943966432419 no 1149 0.380242122510204 1885 676306
SGTC_2108 5365811 200 µM 0.30391939121025 0.347340604083268 no 1150 0.380594652049458 1843 780283
SGTC_3303 9125618 40.5795 µM 0.303859184183614 0.347366410925579 no 1151 0.380617587325966 1853 22695467
SGTC_261 5-fluorouridine 15.376 µM 0.303113029111008 0.347686297839259 no 1152 0.380901862584226 1861 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1113 artemisinin 1.17947 µM 0.302826127454118 0.347809325399857 no 1153 0.381011185461354 1921 2240 An anti-malaria and mitochondrial poison.
SGTC_2136 5328288 199.296 µM 0.30254091660951 0.347931643800804 no 1154 0.381119873475092 1740 262395
SGTC_3139 9095020 49.47 µM 0.300394643552414 0.348852623002866 no 1155 0.381938074482064 1749 25236292
SGTC_2097 5376186 200 µM 0.300282210942542 0.348900893152822 no 1156 0.381980950553703 1875 742755
SGTC_108 0509-0257 621.132 µM 0.299395284067958 0.349281758867789 no 1157 0.382319230006512 1860 536624
SGTC_2671 danthron 100 µM 0.299122750775442 0.349398821110757 no 1158 0.382423193962833 1781 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.298914997068339 0.349488067960165 no 1159 0.382502451982273 1743 2374 Ca(2+)-ATPase inhibitor.
SGTC_1311 1190-0148 100 µM 0.298743858308999 0.349561592008732 no 1160 0.382567745100118 1879 1961333
SGTC_1469 k284-2957 126 µM 0.29802867184612 0.349868909017612 no 1161 0.382840640224532 1830 23884841
SGTC_2475 5812728 15.03 µM 0.297986732540591 0.349886933474036 no 1162 0.382856644895868 1745 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1668 st014914 51.6 µM 0.297699948666126 0.350010195018423 no 1163 0.382966091305241 1802 2839556
SGTC_684 1140-0066 328 µM 0.297440209246592 0.350121846323973 no 1164 0.383065224701902 1767 6813534
SGTC_2645 abamectin 100 µM 0.29538060863544 0.351007642023038 no 1165 0.383851572436651 1874 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_440 fluspirilene 35.1 µM 0.295306621260187 0.351039477713645 no 1166 0.383879829459274 1861 3396 An atypical antipsychotic.
SGTC_173 1273-0061 2.693 µM 0.294941483793703 0.351196606359423 no 1167 0.38401929063631 1708 2847414 YPL266W DIM1
SGTC_3330 9141424 71.43 µM 0.293822740709988 0.351678190415453 no 1168 0.384446678562298 1888 27261020
SGTC_570 0987-0065 62.6 µM 0.293755943314787 0.351706952154415 no 1169 0.384472201293217 1903 3104428
SGTC_1407 3909-7909 12.3 µM 0.293363589119362 0.351875909838935 no 1170 0.384622126685315 1767 4411780
SGTC_2089 5281248 129.67 µM 0.293104730751474 0.351987396848143 no 1171 0.384721050439925 1752 2737878
SGTC_1056 3448-1962 115 µM 0.292745257532756 0.352142238499208 no 1172 0.384858437007596 1815 715507
SGTC_82 0054-0107 293.755 µM 0.292707245156642 0.352158613611945 no 1173 0.384872965750137 1919 3104697
SGTC_2463 5473429 200 µM 0.29134462438138 0.352745789285187 no 1174 0.385393880805923 1780 5399405
SGTC_470 aa-861 153 µM 0.291316399437801 0.352757955591784 no 1175 0.385404673083554 1776 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_968 1309-0633 340 µM 0.290021950771565 0.353316086788023 no 1176 0.385899722337887 1911 3761976
SGTC_623 k072-0108 16.9 µM 0.28997802634017 0.353335031356086 no 1177 0.385916524072958 1819 5382803
SGTC_1810 st050138 53 µM 0.289645225721198 0.353478579770575 no 1178 0.386043832110495 1910 3444541
SGTC_477 mead ethanolamide 10 µM 0.289309027119649 0.35362361501595 no 1179 0.386172452457744 1805 16061185
SGTC_1990 st072050 59.8 µM 0.28898253464821 0.353764483401603 no 1180 0.386297371480758 1757 17233948
SGTC_530 4358-1714 28 µM 0.288980192625712 0.353765493962587 no 1181 0.386298267602703 1847 1564641
SGTC_87 0100-0052 35.5 µM 0.288034451863186 0.354173656479749 no 1182 0.386660183440039 1854 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2373 9071805 200 µM 0.28703320335238 0.354605957652352 no 1183 0.387043448414201 1969 10149009
SGTC_2906 7926292 26.41 µM 0.28632497296902 0.354911857860013 no 1184 0.387314616382693 1792 2966319
SGTC_2371 9071574 200 µM 0.285167856367333 0.355411843077411 no 1185 0.387757772629857 1909 45596039
SGTC_2763 lisinopril 49.32 µM 0.284768556438083 0.355584436718771 no 1186 0.387910731774651 1919 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2676 harmalol 100 µM 0.284640509451226 0.355639790098226 no 1187 0.387959786200436 1881 5459187 A monoamine oxidase inhibitor
SGTC_3292 9120825 59.784 µM 0.284130358161643 0.35586035340709 no 1188 0.38815524141024 1956 24824900
SGTC_2312 7706453 155.7 µM 0.283007204569187 0.356346117524902 no 1189 0.388585657119219 1784 976098
SGTC_2612 dictamnine 15.46 µM 0.282767983817106 0.35644961068888 no 1190 0.388677349156737 1820 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1559 coumarin 343 70.1 µM 0.279178889364473 0.35800361230129 no 1191 0.390053771826968 1873 108770 A hepatotoxic, DNA x-linker.
SGTC_3234 9132280 49.47 µM 0.279073861556886 0.358049122710737 no 1192 0.390094070995988 1827 17612295
SGTC_2489 cantharidin 73.42 µM 0.277938755147289 0.358541113019149 no 1193 0.390529686600674 1741 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_138 0850-0259 40.9225 µM 0.277301924607776 0.358817238022419 no 1194 0.390774140934023 1872 6813004
SGTC_552 k242-0005 476 µM 0.276885117983753 0.358998002253599 no 1195 0.390934160074046 1823 4088318
SGTC_1154 4088-0362 150 µM 0.276523201596786 0.359154986836597 no 1196 0.391073120901377 1793 6618304
SGTC_3269 9137823 49.47 µM 0.275104231289338 0.359770707549074 no 1197 0.39161808043308 1783 17682936
SGTC_66 0109-0187 42.4 µM 0.274608585398895 0.359985864494525 no 1198 0.39180848482253 1698 759417
SGTC_495 decylubiquinone 155 µM 0.272022121591175 0.361109351585078 no 1199 0.392802504958764 1792 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1340 1486-1359 257 µM 0.271442825288614 0.361361146310248 no 1200 0.393025234069005 1845 4309068
SGTC_263 alizarin 107.927 µM 0.269137618162259 0.362363712978499 no 1201 0.39391189147666 1854 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1080 nisoldipine 24.4 µM 0.26856994328406 0.36261074792043 no 1202 0.394130322249218 1827 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_928 2764-0428 58.7 µM 0.268407331142976 0.362681522351925 no 1203 0.394192898526827 1861 662578
SGTC_2736 butenafine 14.65 µM 0.267145995826452 0.363230658309569 no 1204 0.394678377243252 1910 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2020 4017018 200 µM 0.267109040897563 0.363246751283144 no 1205 0.394692603395 1805 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3232 9132874 49.47 µM 0.266277791482816 0.363608803942326 no 1206 0.395012637842628 1783 3784940
SGTC_3271 9137798 49.47 µM 0.266027619815975 0.363717790673873 no 1207 0.395108968843099 1948 6498326
SGTC_1061 3448-9325 110 µM 0.265496714841189 0.363949114773623 no 1208 0.395313420129973 1957 723482
SGTC_1877 wortmannin 25 µM 0.26287223670445 0.365093370411105 no 1209 0.396324527920855 1948 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1965 Pectolinarigenin 58.4 µM 0.262341985488289 0.365324702863231 no 1210 0.396528897720362 1826 5320438 An anti-inflammatory.
SGTC_2646 retinol 96.75 µM 0.261875074704018 0.365528442394596 no 1211 0.396708878347282 1873 445354 A vitamin A analog and teratogen.
SGTC_2815 7968870 71.43 µM 0.259468275205199 0.366579265672676 no 1212 0.397636978375387 1806 2977326 YHR190W ERG9
SGTC_1305 1181-0477 144 µM 0.258933115112948 0.366813056116873 no 1213 0.397843423553417 1961 6252086
SGTC_258 haloperidol 50.781 µM 0.257464596712779 0.367454847783124 no 1214 0.39841007100895 1800 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3014 9081533 49.47 µM 0.254988754157358 0.368537711683182 no 1215 0.399365892544239 1975 21367265
SGTC_3228 9131799 49.47 µM 0.253614104576982 0.36913939643883 no 1216 0.39989684947679 1874 17015818
SGTC_2113 5491891 107.031 µM 0.252124548259913 0.369791738018094 no 1217 0.400472397984732 1791 789979
SGTC_2374 9071832 200 µM 0.2517794106227 0.369942942384144 no 1218 0.400605786341369 1956 17381698
SGTC_1750 st081859 2.357 µM 0.250827043187927 0.370360277590242 no 1219 0.400973916179403 1878 5291695
SGTC_2524 avocatin b 10.57 µM 0.249148004942161 0.371096417405247 no 1220 0.401623148689329 1964 6710748
SGTC_1055 3448-0672 86 µM 0.248479335017046 0.371389713540221 no 1221 0.401881778537291 1884 748378
SGTC_2225 6654152 15.4 µM 0.24731806928338 0.371899252509424 no 1222 0.402331037901588 1935 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2298 7976326 193.81 µM 0.245749119247461 0.372588031120574 no 1223 0.402938223113727 1935 2235818
SGTC_2908 7930301 100 µM 0.245154742909792 0.372849072540162 no 1224 0.403168308575209 1863 2223178
SGTC_2521 angolensin 13.4 µM 0.244451831120981 0.373157856508552 no 1225 0.403440451810628 1897 821428 A flavenoid.
SGTC_3013 9080133 71.4286 µM 0.244090232512338 0.373316735867843 no 1226 0.403580468562812 1906 17050193
SGTC_1671 st016596 74.5 µM 0.243232272047018 0.37369379306546 no 1227 0.403912733965658 1880 2829167
SGTC_1652 st011932 78 µM 0.242912601394872 0.373834313138016 no 1228 0.404036551701469 1958 1551076
SGTC_696 1560-0013 611 µM 0.240703864956897 0.374805681635338 no 1229 0.40489232161557 1938 1650269
SGTC_2938 9059746 27.26 µM 0.239749065239889 0.375225834372179 no 1230 0.405262397712478 1918 6471769
SGTC_26 0302-0163 425.158 µM 0.238665724482948 0.375702729972791 no 1231 0.405682398325566 1898 3100915
SGTC_1094 duloxetine 25.4 µM 0.238636278056809 0.375715695189134 no 1232 0.405693815935171 1893 60834 A selective serotonin reuptake inhibitor.
SGTC_2643 anethole 100 µM 0.238595563417022 0.37573362201385 no 1233 0.405709602834119 1900 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1200 1643-0193 18.4 µM 0.238424601456952 0.375808900201382 no 1234 0.405775894156996 1992 5403974
SGTC_1306 1185-0270 9.02 µM 0.237669980913333 0.376141232123469 no 1235 0.406068534167246 1979 1548076
SGTC_2598 perillyl alcohol 100 µM 0.237225961120968 0.376336819640928 no 1236 0.406240748501153 1938 10819 An apoptosis inducer.
SGTC_490 phenamil 164 µM 0.236778889926043 0.376533783366873 no 1237 0.406414164658352 1977 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1284 0929-0043 16 µM 0.236055027315527 0.376852759729787 no 1238 0.40669498540877 1878 1239883
SGTC_2078 5212016 200 µM 0.236028995771253 0.376864232323883 no 1239 0.406705085178202 2023 1899708
SGTC_3059 1327-0034 3 µM 0.235070863904366 0.377286574736939 no 1240 0.407076866174972 1839 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1327 1436-0082 2.18 µM 0.234474976913663 0.37754931449048 no 1241 0.407308128651366 1887 15992205
SGTC_2069 5228469 200 µM 0.234331713708914 0.377612490861556 no 1242 0.407363733618429 1870 2835210
SGTC_588 3970-1144 52.9 µM 0.233490108907347 0.37798368877267 no 1243 0.407690424637676 1980 1888707
SGTC_183 3914-0051 30.55 µM 0.23328381882367 0.378074692210366 no 1244 0.407770511360201 2031 1596232
SGTC_1861 st057647 17.4 µM 0.23296959242052 0.37821332400553 no 1245 0.407892508937667 2006 688668
SGTC_1481 3346-2004 36 µM 0.232963053056537 0.378216209237691 no 1246 0.407895047923501 1985 2770522
SGTC_2544 sphondin 68.51 µM 0.232449151406924 0.378442968960451 no 1247 0.408094588437891 1961 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3021 9087658 49.47 µM 0.231581097768008 0.37882609372556 no 1248 0.408431695117448 2019 25237042
SGTC_676 falcarinol 140 µM 0.231189734230106 0.378998865187424 no 1249 0.408583702448131 2018 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2038 4100038 30.985 µM 0.230579161980196 0.379268456863299 no 1250 0.408820878872287 1922 3596803
SGTC_1707 st032323 6.317 µM 0.230558953404888 0.379277380749233 no 1251 0.408828729452614 1932 3132057 YMR211W DML1
SGTC_675 1309-0189 238 µM 0.230028589676506 0.379511606557739 no 1252 0.409034776987949 1873 4246530
SGTC_2191 5911152 200 µM 0.230006557954365 0.379521337437469 no 1253 0.409043336907184 1903 2875902
SGTC_1 0258-0098 57.368 µM 0.228754724170192 0.38007436737361 no 1254 0.409529779283049 1890 6790032 YDR047W HEM12
SGTC_1023 4482-3888 16 µM 0.228436865562433 0.380214828725204 no 1255 0.409653316207934 1997 3303168
SGTC_998 3996-0085 177 µM 0.227031619057794 0.380835994612089 no 1256 0.410199577796386 1985 715391
SGTC_1791 st048313 56.1 µM 0.226729419278384 0.380969617205529 no 1257 0.410317074749005 2034 1204976
SGTC_3251 9135047 49.47 µM 0.22641406528504 0.38110907128696 no 1258 0.410439694717071 1998 17682963
SGTC_1780 st038448 24.544 µM 0.225033829253096 0.381719613029362 no 1259 0.410976478590116 1977 728868 YDL195W SEC31
SGTC_3082 9117008 49.47 µM 0.223477600651253 0.382408357376111 no 1260 0.411581907209157 1893 41448529
SGTC_1285 0929-0069 65.5 µM 0.22334682088142 0.382466253918423 no 1261 0.411632794831618 1915 1206237
SGTC_3155 9099265 49.47 µM 0.223037995406787 0.382602982179992 no 1262 0.411752967588456 1946 25236499
SGTC_3284 9108171 64.8615 µM 0.22254344691977 0.382821967245264 no 1263 0.411945427677629 1917 8687505
SGTC_2458 5808907 16.39 µM 0.221817924224528 0.383143294998226 no 1264 0.412227812757659 2035 2731747
SGTC_2511 berberine 10.47 µM 0.221275710377518 0.383383489363298 no 1265 0.412438880774098 1871 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2403 6032726 181.2 µM 0.220827413572694 0.383582113441573 no 1266 0.412613408756453 1895 2881040
SGTC_391 gliotoxin 8.33 µM 0.219644751866033 0.384106254713805 no 1267 0.413073917713458 1956 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2830 7992007 71.43 µM 0.219570056693092 0.38413936583374 no 1268 0.413103006804667 1838 1952075
SGTC_503 tyrphostin 8 294 µM 0.21660893445572 0.385452660620478 no 1269 0.414256561178348 2020 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2205 7238770 200 µM 0.216333892315895 0.385574712201919 no 1270 0.414363746128567 2032 279867
SGTC_2582 agaric acid 100 µM 0.2151822665612 0.386085875886286 no 1271 0.414812608160711 1880 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_404 fumagillin 50 µM 0.214160705393225 0.386539474355968 no 1272 0.415210868852309 1936 12015870 A methionine aminopeptidase binder.
SGTC_1465 k213-0056 144 µM 0.214099497085052 0.386566657291457 no 1273 0.415234733985973 1903 24048857 YMR208W ERG12
SGTC_454 lyso-paf C-16 6.67 µM 0.213530824982938 0.386819234191037 no 1274 0.415456474310959 1838 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2575 plumbagin 510 nM 0.212941481535089 0.38708104290119 no 1275 0.415686303354013 1848 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2208 7283366 200 µM 0.212856894694283 0.387118623802968 no 1276 0.415719292452 2021 898663
SGTC_1359 1582-0056 520 nM 0.211419319997628 0.387757482242852 no 1277 0.416280041138208 1978 3661189
SGTC_2413 inermin 26.06 µM 0.21124606762209 0.387834496186336 no 1278 0.416347632491262 2062 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2825 7998094 58.44 µM 0.211070059508499 0.387912739625578 no 1279 0.416416301479963 1945 2987815
SGTC_780 0109-0199 192 µM 0.210824522546605 0.388021899334141 no 1280 0.416512101182326 2045 610414
SGTC_1084 voriconazole 435 nM 0.210357158140313 0.388229702525603 no 1281 0.416694463684026 2056 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2437 5741531 144.16 µM 0.210197602562044 0.38830065269636 no 1282 0.41675672532317 2046 2262990
SGTC_2988 9073640 71.4286 µM 0.209924604319212 0.388422056481707 no 1283 0.416863259302487 1953 9102229
SGTC_794 k038-0031 316 µM 0.209757767247621 0.38849625519143 no 1284 0.416928368285073 1920 6624242
SGTC_485 niflumic acid 177 µM 0.208288562950166 0.389149840905722 no 1285 0.41750183063111 2007 4488 A COX2 inhibitor.
SGTC_1441 4106-0040 13 µM 0.208213853511329 0.38918308431619 no 1286 0.417530996047129 2027 2904180
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.206923887444181 0.389757207402444 no 1287 0.418034650374779 2101 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_339 3091-4833 71.4 µM 0.205625890650923 0.390335147609184 no 1288 0.41854157593125 1984 3240077
SGTC_633 0437-0093 97.7 µM 0.204682381636489 0.390755402420936 no 1289 0.418910143199273 1942 2831118
SGTC_279 1273-0055 2.93 µM 0.202361673159439 0.391789627186213 no 1290 0.419816994454251 2066 2847562
SGTC_1634 st006576 41 µM 0.202191780620549 0.391865370018183 no 1291 0.419883399274073 2073 3915356
SGTC_717 1532-0246 73.2 µM 0.199713114169308 0.392970893350475 no 1292 0.420852478385934 1935 9561992
SGTC_3174 9107204 49.47 µM 0.199583556342275 0.393028701965178 no 1293 0.420903144587854 2028 3938802
SGTC_912 3474-0017 2.18 µM 0.199558969456067 0.393039672883531 no 1294 0.420912759933645 2007 3360550
SGTC_2174 5790901 200 µM 0.198740814746295 0.393404790223255 no 1295 0.421232747631458 1945 786020
SGTC_842 0271-0008 11.1 µM 0.198378367969701 0.393566569085547 no 1296 0.421374520483909 2004 1221709
SGTC_2238 6671620 73.2395 µM 0.197991681778778 0.393739187519365 no 1297 0.421525785942416 2045 729941
SGTC_1222 0366-0074 1.18 µM 0.197970120341364 0.393748813255813 no 1298 0.421534220773266 2069 286520
SGTC_48 0382-0018 55 µM 0.197133480936053 0.394122366747079 no 1299 0.421861541740751 2073 762596
SGTC_2124 5246320 200 µM 0.196026586848363 0.394616736672668 no 1300 0.422294678195312 1958 579342
SGTC_1236 0330-0013 258 µM 0.194648886335371 0.395232293409181 no 1301 0.42283391459732 1939 4617066
SGTC_1556 plumbagin 1.48 µM 0.194474080897324 0.395310415225955 no 1302 0.422902344366575 2046 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2955 9076254 12.21 µM 0.192722314841392 0.396093524030428 no 1303 0.42358822317326 2076 16459619
SGTC_2019 4016004 108 µM 0.192630696248725 0.396134492740975 no 1304 0.423624101506283 1901 45595336
SGTC_1996 st072960 66.8 µM 0.191389271757 0.39668972834688 no 1305 0.424110312304414 2087 1719405
SGTC_2183 6420625 130.508 µM 0.191335279371482 0.396713881573876 no 1306 0.424131461349061 2011 2897619
SGTC_2878 9043973 25.97 µM 0.19014696443427 0.397245568575752 no 1307 0.424596984526438 2062 6465167
SGTC_1718 roemerine 11.9335 µM 0.189516238297911 0.397527851632498 no 1308 0.424844114692377 2062 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2894 9048625 32.47 µM 0.188964027720749 0.397775038925714 no 1309 0.425060505267821 2076 4092861
SGTC_230 MPP+ 141.667 µM 0.187488811643184 0.398435594337248 no 1310 0.425638697582741 1920 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3101 9120531 49.47 µM 0.186866677342073 0.398714253914071 no 1311 0.425882583285648 2078 24824904
SGTC_2835 9006588 71.43 µM 0.186710819834435 0.398784071995199 no 1312 0.425943686142665 1920 2345538
SGTC_3076 9116187 49.47 µM 0.185558057683065 0.399300564884121 no 1313 0.426395673681693 2079 27241210
SGTC_271 rotenone 740 µM 0.184930868613907 0.399581649873174 no 1314 0.426641629454957 2028 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_851 0394-0702 453 µM 0.184908330267127 0.399591751769876 no 1315 0.426650468527874 2098 762646
SGTC_1466 k213-0079 57.5 µM 0.183972268331723 0.400011362727371 no 1316 0.427017605119881 1972 3657981
SGTC_1958 st076513 41.9 µM 0.183707058510092 0.400130270049079 no 1317 0.427121635632375 1961 732122 YGL099W LSG1
SGTC_2761 levamisole 97.89 µM 0.182456647369065 0.400691018799212 no 1318 0.42761218680961 2088 26879 An alkaline phosphatase inhibitor.
SGTC_1456 k015-0012 13 µM 0.182185577798688 0.400812607393255 no 1319 0.427718545417218 2137 2989616
SGTC_1146 3579-1023 7 µM 0.181323784185668 0.401199229780767 no 1320 0.428056719184847 2090 X1146
SGTC_3075 9116269 49.47 µM 0.180662763367774 0.401495846017426 no 1321 0.428316144147753 2006 17015205 YNL244C SUI1
SGTC_167 3672-0051 66.205 µM 0.179016084623171 0.402234997613467 no 1322 0.42896253600143 2005 3237971
SGTC_2750 bromebric acid 70.15 µM 0.178393067605947 0.402514745209974 no 1323 0.429207146616934 1992 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_902 1120-0002 2.07 µM 0.177914757490202 0.40272955028614 no 1324 0.42939496047377 2057 3280475
SGTC_2707 st078556 66.6 µM 0.177670696484607 0.402839167363493 no 1325 0.429490799938996 2112 17250899
SGTC_3215 9129942 49.47 µM 0.176873720557552 0.403197172703704 no 1326 0.429803790551187 2120 17682944
SGTC_2212 7123476 200 µM 0.176223891522901 0.403489139042906 no 1327 0.430059025889263 2065 1085715
SGTC_2850 9015429 58.44 µM 0.173076615168523 0.404903959785838 no 1328 0.431295602965918 1994 6457570
SGTC_220 paclitaxel 373.376 µM 0.17278258809651 0.405036199988621 no 1329 0.43141116193847 2082 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.17229383471741 0.40525604334798 no 1330 0.431603265529851 2067 3256 An antibiotic and ribosome inhibitor.
SGTC_1927 st060202 13.8 µM 0.172132851040905 0.405328461042838 no 1331 0.43166654340344 2119 688887
SGTC_2982 9019404 25.97 µM 0.17021157334975 0.406192987624703 no 1332 0.432421875157604 1807 22333232
SGTC_637 1181-0519 7.26 µM 0.170129433970469 0.406229958506125 no 1333 0.432454172986723 2057 6252091 YGR060W ERG25
SGTC_412 gemfibrozil 100 µM 0.169193510406206 0.406651276057563 no 1334 0.432822217074526 2112 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1430 4049-0248 69.1 µM 0.167800621516208 0.407278502173569 no 1335 0.433370066766787 2115 22774488
SGTC_2402 5553605 200 µM 0.166971271443324 0.407652076489411 no 1336 0.433696326816125 2068 6758546
SGTC_384 k007-0144 5.16 µM 0.166941297737653 0.407665579487566 no 1337 0.433708119092657 2019 6824886
SGTC_1266 0828-0227 32.9 µM 0.164436825896585 0.408794216996605 no 1338 0.434693637623015 2034 3913820
SGTC_181 1447-1644 8.07 µM 0.164359679378058 0.408828995052899 no 1339 0.434724001526744 2117 534600
SGTC_2239 6685329 187.64 µM 0.163928535096273 0.409023370371398 no 1340 0.434893701601014 1980 805680
SGTC_2325 6158266 200 µM 0.163523160362489 0.409206148261904 no 1341 0.435053269621403 2002 3623240
SGTC_1328 1441-0025 69.2 µM 0.163396146002308 0.409263421353096 no 1342 0.435103268575612 2086 4562601
SGTC_2073 5212005 126 µM 0.162883182387404 0.409494745696205 no 1343 0.43530520624808 2165 691789
SGTC_328 k915-0120 63.5 µM 0.162561822131194 0.409639681294981 no 1344 0.435431724292743 2110 6624543
SGTC_2029 5175081 200 µM 0.1625080638318 0.409663927849421 no 1345 0.435452889331925 2102 1380876
SGTC_917 harmaline 728.087 nM 0.16171447314894 0.41002190044501 no 1346 0.43576535332023 2045 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1713 st033146 12.748 µM 0.161704442959386 0.410026425339831 no 1347 0.435769302808398 2115 674619
SGTC_2192 5915882 198.485 µM 0.16143626890742 0.410147410482883 no 1348 0.435874901416599 2094 2876149
SGTC_838 0109-0203 71.4 µM 0.161158277870927 0.410272833529192 no 1349 0.435984370474031 2051 759422
SGTC_1449 4112-4002 201 µM 0.160753735619001 0.410455369914558 no 1350 0.43614368242372 1947 2059539
SGTC_1117 retinoic acid 1.10837 µM 0.159816417000618 0.410878378593559 no 1351 0.436512845705305 2133 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_903 1134-0042 114 µM 0.15925807766807 0.411130404519872 no 1352 0.436732774160079 1990 701009
SGTC_357 1325-0123 420 µM 0.159200299418357 0.411156486843775 no 1353 0.436755533984656 2130 1098503
SGTC_706 4262-0057 46.9 µM 0.158245603392531 0.411587513594845 no 1354 0.437131635063649 2059 883298
SGTC_2141 5621638 7.665 µM 0.158197959124665 0.411609026858378 no 1355 0.437150405943539 2110 2856238
SGTC_349 k015-0014 24 µM 0.157851453676505 0.411765495706304 no 1356 0.437286926349805 1978 2196908
SGTC_921 1561-0023 372 µM 0.15743620276407 0.411953025905345 no 1357 0.437450541760529 2129 24050882
SGTC_2843 9000894 45.46 µM 0.157080029262496 0.412113892358298 no 1358 0.437590888262686 2125 2242070
SGTC_3221 9128209 49.47 µM 0.156940857474645 0.412176753580523 no 1359 0.437645729607683 2031 16460723
SGTC_1499 4480-0877 67.3 µM 0.156560929033326 0.412348371424203 no 1360 0.437795448421799 2119 2861909
SGTC_2466 5983409 37.09 µM 0.155992505430933 0.4126051658871 no 1361 0.438019464352184 2017 2879657
SGTC_282 k297-0036 65.7 µM 0.155293849068059 0.412920846324628 no 1362 0.43829483226175 2098 5061378
SGTC_800 3448-7362 155 µM 0.155287026535857 0.412923929291152 no 1363 0.438297521437141 2153 15991913
SGTC_1442 4112-3290 3 µM 0.154384356593144 0.413331875164848 no 1364 0.438653343706431 2125 704353
SGTC_1783 st039459 87.517 µM 0.15432187517918 0.413360116013833 no 1365 0.438677975010581 2141 729761
SGTC_2975 9084847 53.72 µM 0.15390174753696 0.413550020297654 no 1366 0.43884360309336 1976 27211724
SGTC_421 streptovitacin 30 mM 0.153518794185849 0.41372313883869 no 1367 0.438994585183319 1989 91467 include heat shock
SGTC_225 nsc-122657 1.016 µM 0.153474534612465 0.41374314797821 no 1368 0.439012035408439 2107 275685
SGTC_3102 9121669 49.47 µM 0.152988221060715 0.413963018331752 no 1369 0.439203782086098 2025 41905072
SGTC_869 0564-0080 44.1 µM 0.152613524906268 0.414132443024954 no 1370 0.439351529307557 1960 6843321
SGTC_2966 9084041 48.03 µM 0.150830291017735 0.414938978449958 no 1371 0.440054795417461 1858 17741380
SGTC_2316 5844804 197.44 µM 0.150681783989716 0.415006162632534 no 1372 0.440113371710456 2155 776813
SGTC_150 3970-0969 77.2 µM 0.150485200928017 0.415095100106962 no 1373 0.440190912864781 2031 6615640
SGTC_1524 corynanthine 62.1 µM 0.14941067968242 0.415581308317763 no 1374 0.440614792576326 2050 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3254 9136651 49.47 µM 0.149194489849044 0.41567914731681 no 1375 0.440700083898297 2127 16454030
SGTC_3173 9105693 49.47 µM 0.149038455363997 0.415749765624062 no 1376 0.44076164441149 2097 17096658
SGTC_2531 methyl deoxycholate 70.07 µM 0.147921981431831 0.416255140223242 no 1377 0.441202170184222 2031 16667744 Haematoxylin.
SGTC_3149 9097855 49.47 µM 0.146340822279602 0.416971092456652 no 1378 0.441826170601987 2137 25236625 YMR079W SEC14
SGTC_2667 digitoxin 100 µM 0.145826197324397 0.417204175262622 no 1379 0.442029297247314 2167 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2546 rhodinyl acetate 100 µM 0.144772494208658 0.41768150687266 no 1380 0.442445249920381 2169 6708682
SGTC_2969 9091408 28.7 µM 0.144625912241504 0.417747918701678 no 1381 0.442503118658561 1902 4286311
SGTC_1031 k035-0009 16 µM 0.144242906334337 0.417921458092078 no 1382 0.442654330416367 2139 5180959
SGTC_660 4031-1742 102 µM 0.143738121787106 0.418150199606899 no 1383 0.442853633464525 2034 6738706
SGTC_2624 nerol 100 µM 0.143089091036588 0.4184443465069 no 1384 0.443109910188915 2098 637566 A natural product oil.
SGTC_1427 4048-4900 550 nM 0.142662649815598 0.418637638558911 no 1385 0.44327830802342 2162 24132586
SGTC_1608 st001473 40.5 µM 0.142478983110217 0.418720894808511 no 1386 0.443350839525421 1975 7292267
SGTC_799 1310-0557 151 µM 0.14169943130637 0.419074306678032 no 1387 0.443658712080355 2050 5354492
SGTC_658 3253-0951 102 µM 0.14105434515601 0.419366807583998 no 1388 0.443913505121395 2076 1184878
SGTC_2342 7990637 118.86 µM 0.140435767846712 0.419647330465026 no 1389 0.444157849604238 2056 2033102 YER133W GLC7
SGTC_1192 1488-0095 21.4 µM 0.140299892153568 0.419708955143635 no 1390 0.444211524765542 2051 915875
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.139849876177064 0.419913068172097 no 1391 0.444389302494701 2169 1273210
SGTC_663 1486-0733 13.9 µM 0.138988099529397 0.420304002920067 no 1392 0.444729776485386 2051 722445 YPR165W RHO1
SGTC_629 3448-6466 76.7 µM 0.138564132662743 0.420496359339522 no 1393 0.444897293908048 2122 573744
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.137323469478926 0.421059364902278 no 1394 0.445387560103217 2064 689007
SGTC_1807 st050092 58.9 µM 0.137253141603338 0.421091284120009 no 1395 0.445415353700225 2065 5008496
SGTC_3341 9147222 25.867 µM 0.136937132144381 0.421234715506559 no 1396 0.445540244040065 2072 1939759
SGTC_1588 farnesol 29.9 µM 0.136373643606787 0.421490499417829 no 1397 0.445762954178458 2025 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1837 st055472 66.5 µM 0.135630966741652 0.421827672741714 no 1398 0.446056511867436 2112 676091
SGTC_3066 9117245 49.47 µM 0.13556977570954 0.421855455866726 no 1399 0.44608070015137 2106 17176980
SGTC_840 0245-0196 390 µM 0.135127685525395 0.422056193671703 no 1400 0.446255460520651 2141 3827528
SGTC_1231 0242-0792 125 µM 0.134336186862564 0.422415636288143 no 1401 0.44656836979298 2048 3707635
SGTC_1361 1608-0041 5.61 µM 0.134019049948016 0.422559675555948 no 1402 0.446693755323353 2081 X1361
SGTC_1742 st038235 28.8875 µM 0.133968529185094 0.42258262235521 no 1403 0.446713730067794 2045 564103 YBR002C RER2
SGTC_125 0133-0007 11.75 µM 0.133551324985814 0.422772128758007 no 1404 0.446878688149126 2189 26541
SGTC_2845 9003024 42.97 µM 0.133220911456606 0.422922224974393 no 1405 0.447009336650692 2151 2990173
SGTC_506 n9-isopropylolomoucine 153 µM 0.132893518793487 0.423070959945458 no 1406 0.447138796346875 2202 6610355
SGTC_858 0438-0351 2.77 µM 0.132207275983471 0.423382756625228 no 1407 0.447410173119219 2057 2799119
SGTC_1548 st061468 90.8 µM 0.131602847697912 0.423657420359041 no 1408 0.447649216491125 2155 390799
SGTC_2213 7173844 200 µM 0.131040296373532 0.423913087736641 no 1409 0.447871715166775 2148 892728
SGTC_2620 irigenin 100 µM 0.130798825867592 0.424022840676135 no 1410 0.447967225919553 2120 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2002 4023503 131 µM 0.130416106226038 0.424196806104115 no 1411 0.448118612245639 2213 4736863 YCR052W RSC6
SGTC_1033 k072-0102 21.3 µM 0.129902298234051 0.424430381035637 no 1412 0.448321862985025 2189 5965931
SGTC_3346 9158254 43.5805 µM 0.128876462698739 0.424896800831701 no 1413 0.44872770068816 2087 17639500
SGTC_160 3453-0671 289.699 µM 0.127961982982638 0.425312678814869 no 1414 0.449089529415654 2128 5322268
SGTC_1738 st035555 74 µM 0.127468480028844 0.425537143736572 no 1415 0.449284809471271 2102 5331140
SGTC_713 1488-1073 324 µM 0.125549554954906 0.426410176501044 no 1416 0.450044248090166 2199 3312542
SGTC_562 3772-2733 112 µM 0.124778456673571 0.426761096658076 no 1417 0.450349471581341 2173 2876874 YIL048W NEO1
SGTC_2827 7993847 71.43 µM 0.124323926273765 0.426967976689285 no 1418 0.450529401917801 2094 2985692
SGTC_3178 9107506 49.47 µM 0.123956520603427 0.427135216485616 no 1419 0.45067485050478 2137 8897194
SGTC_1381 2324-0066 62.1 µM 0.120879243354901 0.428536477148226 no 1420 0.451893341501246 2092 10885928
SGTC_885 0865-0106 16.8 µM 0.120782980225295 0.428580325898694 no 1421 0.451931465606389 2160 2793380
SGTC_2962 9082311 13.18 µM 0.117798370146922 0.429940278336376 no 1422 0.453113710495629 2098 16459453
SGTC_2452 5863136 48.41 µM 0.117752931162161 0.429960989303707 no 1423 0.453131712738364 2172 2184096
SGTC_2769 toremifene 3.73 µM 0.117093600875977 0.43026153193774 no 1424 0.45339294030733 2149 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2130 NSC 7 2.4545 µM 0.116606975596655 0.430483376346238 no 1425 0.453585754856544 2184 21448
SGTC_535 2293-4129 48.2 µM 0.116509281063062 0.430527916313683 no 1426 0.453624465484028 2192 396118 YIL048W NEO1
SGTC_3116 9124943 49.47 µM 0.116495384453392 0.430534251996299 no 1427 0.453629971933143 1994 41905195 YPL160W CDC60
SGTC_2765 myclobutanil 7.74 µM 0.116493725200437 0.430535008476977 no 1428 0.453630629402876 2094 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2061 5245884 80.95 µM 0.116245844289853 0.430648024318213 no 1429 0.453728852258353 2160 573863
SGTC_3126 9127922 49.47 µM 0.115993608307306 0.430763031589436 no 1430 0.453828803717216 2129 45595682
SGTC_1503 4585-0012 61.3 µM 0.112922519970953 0.432163765803704 no 1431 0.455045991084485 2157 2922052
SGTC_1844 rapamycin 4 nM 0.11271779501223 0.432257172104912 no 1432 0.455127146391111 2089 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2571 chrysanthemic acid 100 µM 0.111838029921626 0.432658610277029 no 1433 0.455475916572583 2046 2743 An insecticide.
SGTC_2007 4011539 71.82 µM 0.111295476883654 0.432906212749373 no 1434 0.45569102102405 2145 45595301
SGTC_3286 9117135 37.221 µM 0.111120517554647 0.432986063767812 no 1435 0.455760389421625 2084 3438150
SGTC_2288 7946289 167.31 µM 0.110100477614234 0.433451661930377 no 1436 0.456164844690106 2200 1246052
SGTC_2739 tacrine 100.86 µM 0.109443128599455 0.433751758474731 no 1437 0.456425513748431 2139 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3201 9113999 49.47 µM 0.109140405573861 0.433889972090066 no 1438 0.456545563637467 2177 16649224
SGTC_2049 5262831 67.185 µM 0.106025033737227 0.4353128175173 no 1439 0.457781245040307 2134 763417
SGTC_569 4130-2812 160 µM 0.103498939440849 0.436467145536779 no 1440 0.458783495589462 2264 743552
SGTC_1849 st056239 19.2 µM 0.103157485919005 0.436623218418018 no 1441 0.45891899058034 2016 5393181
SGTC_102 gallobenzophenone 83.616 µM 0.102429952279441 0.43695579515272 no 1442 0.459207705108635 2227 70837
SGTC_894 0960-0238 55.9 µM 0.101393235335896 0.437429785480407 no 1443 0.459619153110588 2213 6741907 YDL195W SEC31
SGTC_2151 5563267 85.4165 µM 0.10068212953582 0.437754957315616 no 1444 0.45990139892192 2093 5310824
SGTC_1204 4049-0315 18.3 µM 0.0996034724125624 0.438248281842994 no 1445 0.46032956847559 2183 588402
SGTC_2507 purpurin 79.67 µM 0.0987428033626411 0.438641978264541 no 1446 0.460671241370728 2204 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3188 9110789 49.47 µM 0.0974102135599929 0.439251665366142 no 1447 0.461200317027781 2215 849217
SGTC_148 3253-0744 288.01 µM 0.0958302767434008 0.439974705432246 no 1448 0.461827685324703 2261 6893655
SGTC_3175 9106517 49.47 µM 0.0949965740661712 0.440356320816972 no 1449 0.462158774057345 2140 41468073
SGTC_3227 9130768 49.47 µM 0.0943327622642818 0.440660210741402 no 1450 0.462422412710445 2230 17720899
SGTC_723 4182-0001 115 µM 0.0939715532843207 0.440825585210323 no 1451 0.462565876953912 2110 744821 YLR208W SEC13
SGTC_1893 st059353 36.1 µM 0.0930976700803196 0.441225723018956 no 1452 0.462912984202635 2096 3112488
SGTC_394 menadione 8.33 µM 0.0922416011162378 0.441617762142674 no 1453 0.463253043002777 2254 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_134 0269-0018 6.916 µM 0.0911122582146403 0.442135035261353 no 1454 0.463701696255589 2142 4378915
SGTC_1522 st012842 45.6 µM 0.0908559318417421 0.442252454245245 no 1455 0.463803533300611 2207 3491067 YOR116C RPO31
SGTC_2873 9040596 71.43 µM 0.0894605922619705 0.442891725555697 no 1456 0.464357935392554 2094 6463863
SGTC_3300 9124615 50.48 µM 0.0892597581607378 0.442983749473321 no 1457 0.464437737350907 2218 24824903
SGTC_100 0086-0128 49.5915 µM 0.0892476129452362 0.442989314614505 no 1458 0.464442563330135 2142 93297
SGTC_2442 5158906 48.48 µM 0.0889092893266108 0.443144344680276 no 1459 0.4645770004885 2213 1893835
SGTC_3194 9111903 49.47 µM 0.0883558414202681 0.443397969925012 no 1460 0.464796928708242 2218 17087251
SGTC_2416 tofa 880 nM 0.0876985663910281 0.443699205516691 no 1461 0.465058129544572 1979 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2096 5468907 200 µM 0.0872638871814964 0.443898441145242 no 1462 0.465230879168582 2234 759785
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0869101924742249 0.444060567915981 no 1463 0.465371448877916 2221 23847180
SGTC_1715 st032160 10.2275 µM 0.0866227431541528 0.444192335987521 no 1464 0.465485693712828 2220 5289825
SGTC_3296 9122258 64.045 µM 0.0863216980327471 0.444330343049376 no 1465 0.465605345158776 2179 4730474
SGTC_3222 9128301 49.47 µM 0.0843119651092481 0.445251830023369 no 1466 0.466404199747162 2215 4911358
SGTC_1410 3909-8106 77.9 µM 0.0836059350126485 0.445575623893243 no 1467 0.466684874001552 2239 1039210
SGTC_247 mechlorethamine 29.705 µM 0.0820012532264978 0.446311684901428 no 1468 0.467322858441637 2186 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3320 9137005 35.139 µM 0.0815752351677702 0.446507128839163 no 1469 0.467492247558947 2101 4908713
SGTC_1244 0416-0015 52.5 µM 0.080977678507096 0.446781291280531 no 1470 0.467729852083416 2194 96201
SGTC_2823 7987624 58.44 µM 0.0805014356686716 0.446999812462725 no 1471 0.467919227222039 2195 2239440
SGTC_2352 9027995 87.8 µM 0.0804721281910399 0.447013260550096 no 1472 0.46793088140419 2193 2997347
SGTC_370 0180-0345 38.7 µM 0.0798007886739258 0.447321329385667 no 1473 0.468197848527704 2198 3989527
SGTC_96 0929-0093 37.281 µM 0.0793358912149477 0.447534683326036 no 1474 0.468382729598987 2129 6991579
SGTC_553 k007-0256 45.7 µM 0.0792713464932699 0.447564305835363 no 1475 0.468408398374112 2177 6287000
SGTC_1130 3454-2858 15.9 µM 0.0789701405756051 0.447702546799174 no 1476 0.468528186619197 2108 715628 YIL048W NEO1
SGTC_2117 5521686 200 µM 0.0785443667637128 0.447897970068109 no 1477 0.46869751981624 2210 803312
SGTC_3017 9080681 49.47 µM 0.0780134812936884 0.448141655592042 no 1478 0.468908664577549 2165 16451914
SGTC_2389 9091542 195.52 µM 0.077680950574788 0.448294302862034 no 1479 0.469040923774595 2128 3626624 YOL127W RPL25
SGTC_1917 st066507 28.5 µM 0.0774756093384549 0.448388567990906 no 1480 0.469122596934933 2165 3156428
SGTC_2065 5221596 34.26 µM 0.0768217381219437 0.44868875726083 no 1481 0.469382678659159 2223 788581
SGTC_595 3909-8003 73.7 µM 0.0766347110268888 0.448774625951404 no 1482 0.469457072366151 2215 699517
SGTC_1073 triclabendazole 3.09 µM 0.0756656599325375 0.449219579228868 no 1483 0.469842548523315 2169 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2888 9058547 12.99 µM 0.0747708655152303 0.449630493247913 no 1484 0.470198511429978 2252 16476514
SGTC_736 0958-0254 92.6 µM 0.0727909862408068 0.450539899221038 no 1485 0.470986221933594 2215 6812352
SGTC_853 0419-0306 21 µM 0.0727676543353994 0.450550617681842 no 1486 0.470995505398093 2134 762713
SGTC_2116 5511452 16.8835 µM 0.0724199017415228 0.450710376266322 no 1487 0.471133873539326 2211 870744
SGTC_3189 9110682 49.47 µM 0.0712787500929367 0.451234680719332 no 1488 0.471587953587252 2206 17122418
SGTC_3119 9125183 49.47 µM 0.0708556505485018 0.451429096339049 no 1489 0.471756320174127 2279 22695334
SGTC_1675 st018485 24.5 µM 0.0708548312440771 0.45142947282342 no 1490 0.471756646209849 2144 3323024
SGTC_1408 3909-7976 48.8 µM 0.0706367957282357 0.451529665417161 no 1491 0.471843412392589 2221 24152374
SGTC_3244 9134489 49.47 µM 0.0693622199324292 0.452115425404741 no 1492 0.472350650293931 2171 16584271
SGTC_2330 7979373 200 µM 0.0693615359929538 0.452115739752616 no 1493 0.472350922490737 2226 1863007
SGTC_2836 9010338 19.48 µM 0.0692846400288654 0.452151082373768 no 1494 0.472381525918278 2199 2994051
SGTC_192 3455-0609 60.9 µM 0.0686426638245671 0.452446159727076 no 1495 0.472637029057234 2226 3769639
SGTC_1181 1222-0449 220 µM 0.0686305851929111 0.452451711790501 no 1496 0.472641836397088 2259 658318
SGTC_617 3770-0098 35 µM 0.0684001504521657 0.452557635195168 no 1497 0.472733551034443 2197 5962639
SGTC_2789 5281112 71.43 µM 0.0680278055124525 0.452728797265427 no 1498 0.472881749975812 2222 765948
SGTC_2115 tiliquinol 12.7705 µM 0.0677896495073552 0.452838279055803 no 1499 0.472976541652746 2238 71208 A bioactive hydroxyquinoline.
SGTC_2751 anetholtrithion 17.25 µM 0.0675053963176296 0.452968956700203 no 1500 0.473089683093476 2251 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1572 epiandrosterone 68.9 µM 0.0674711308085901 0.452984709676892 no 1501 0.473103321958162 2224 441302 A steroid.
SGTC_2572 astragaloside iv 100 µM 0.0670226476248902 0.453190898896932 no 1502 0.473281836769178 2196 45006101 An anti-inflammatory agent.
SGTC_45 0kpi-0036 14.9 µM 0.0668881000558861 0.453252759328214 no 1503 0.473335393300937 2239 2795021
SGTC_3117 9124945 49.47 µM 0.0662772996449528 0.453533598984666 no 1504 0.473578527869336 2225 17592065
SGTC_1840 st055363 71 µM 0.0654552979995868 0.453911583421392 no 1505 0.473905748498667 2145 676033
SGTC_3277 9138724 49.47 µM 0.065113472398295 0.45406877881973 no 1506 0.474041826887169 2182 15943418
SGTC_2193 5925765 200 µM 0.0649981345627484 0.454121820874786 no 1507 0.474087742759495 2266 877370
SGTC_10 0279-0212 42.575 µM 0.0649118803259758 0.454161488375376 no 1508 0.47412208070641 2293 39851 YBR002C RER2
SGTC_64 000l-0018 272.079 µM 0.0648704738044786 0.454180531002029 no 1509 0.474138564775863 2241 6811119
SGTC_2066 5222451 176 µM 0.0639685028052318 0.454595368459111 no 1510 0.474497653272101 2289 2281147
SGTC_3147 9097027 49.47 µM 0.0621085107968398 0.455450977950967 no 1511 0.475238209724771 2242 25236841
SGTC_3263 9137018 49.47 µM 0.0620881466548156 0.455460346751458 no 1512 0.475246318193 2219 43844957
SGTC_2433 5607874 27.82 µM 0.0610846013451849 0.455922072003456 no 1513 0.475645916297423 2279 2252428
SGTC_294 k038-0071 157 µM 0.0598740924223638 0.45647909914941 no 1514 0.476127957058874 2234 24152826
SGTC_1318 1280-3875 124 µM 0.0588408739181615 0.456954612135158 no 1515 0.476539426081339 2258 373245
SGTC_234 nsc-17383 10.7 µM 0.0573196558278123 0.457654826723795 no 1516 0.477145281503465 2292 408974
SGTC_873 0591-4978 488 µM 0.0551935218526507 0.45863370305123 no 1517 0.477992144941561 2304 3305145
SGTC_918 glabranin 770.725 nM 0.0547416493668754 0.458841778575352 no 1518 0.478172143846913 2255 124049 Also referred to as licorice root.
SGTC_1325 1431-0015 227 µM 0.0524182379044434 0.459911825935281 no 1519 0.479097721173688 2284 1103340
SGTC_281 1672-3440 14.9 µM 0.0510797060459165 0.460528419257749 no 1520 0.479631003554295 2294 6833000
SGTC_2841 9004761 38.96 µM 0.0509694624139133 0.460579207124372 no 1521 0.479674927185225 2259 2991039
SGTC_1753 st043925 64 µM 0.0493848205059584 0.461309302542815 no 1522 0.480306312441418 2295 670181
SGTC_782 0083-0095 30.5 µM 0.0493205064561274 0.461338936861648 no 1523 0.480331938807221 2346 3591729 An indicator and reagent.
SGTC_993 3909-8757 62.7 µM 0.0490034112665053 0.461485049594684 no 1524 0.48045828870503 2274 4288324 YLR208W SEC13
SGTC_2479 5617353 43.85 µM 0.0488097650720699 0.461574281430436 no 1525 0.480535450024787 2315 2731746
SGTC_756 0508-1999 28.3 µM 0.0481649834155018 0.461871409635463 no 1526 0.480792378484513 2283 6753853
SGTC_1699 st031318 29.054 µM 0.0477006195192148 0.462085410941903 no 1527 0.480977420180833 2295 5340658
SGTC_2989 9073649 71.4286 µM 0.0470782029664653 0.462372267749779 no 1528 0.481225449792293 2332 21367202
SGTC_406 estrone 100 µM 0.0451591646261426 0.463256828880297 no 1529 0.481990221465064 2328 5870 A steroid.
SGTC_1987 st072290 61.9 µM 0.0443261084621257 0.463640874428794 no 1530 0.482322230290054 2220 54697379
SGTC_103 0844-0104 51.839 µM 0.0443068443973727 0.463649755718802 no 1531 0.482329907996957 2330 5375804
SGTC_2851 9015922 71.43 µM 0.0438639709671262 0.463853938142551 no 1532 0.482506417323357 2313 2996893
SGTC_3019 9081971 49.47 µM 0.042149536670657 0.464644450438969 no 1533 0.48318974534007 2317 16451803
SGTC_3009 9080819 71.4286 µM 0.041223732216397 0.465071389894156 no 1534 0.483558767089275 2283 17027216
SGTC_2842 9000675 19.48 µM 0.0411603709704321 0.465100610732302 no 1535 0.483584023133094 2271 2989072
SGTC_839 0122-0028 230 µM 0.0409972421581238 0.465175843082844 no 1536 0.483649047227202 2298 759448
SGTC_71 0417-1750 47.813 µM 0.0403613263057724 0.465469128973069 no 1537 0.48390253112332 2344 6811472
SGTC_1841 st054148 70 µM 0.0402981652173253 0.465498260042597 no 1538 0.483927708268479 2226 675442
SGTC_2928 9011484 9.79 µM 0.0399888324840514 0.465640932723551 no 1539 0.484051014779712 2289 2994751
SGTC_3007 9078383 71.4286 µM 0.0384208469356909 0.466364197911121 no 1540 0.48467606990046 2314 6496995
SGTC_432 NS 1619 61.3 µM 0.0381732750363218 0.466478405695657 no 1541 0.484774764395887 2225 4552 A K+/calcium channel activator.
SGTC_224 benfluorex 43.875 µM 0.0373964416228865 0.466836785822541 no 1542 0.485084454930734 2341 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_778 3456-2434 196 µM 0.0363681296139995 0.467311223030591 no 1543 0.48549441312195 2324 5539063
SGTC_2909 7941780 10.49 µM 0.0356941140362377 0.467622222046618 no 1544 0.485763131940866 2342 1243215
SGTC_316 k060-0003 58.6 µM 0.0350941362700485 0.46789907574543 no 1545 0.486002338556242 2330 6152314
SGTC_256 clotrimazole 625 nM 0.0348087036641753 0.46803079120612 no 1546 0.486116140159192 2331 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1020 4335-0961 93.3 µM 0.0343480127184779 0.468243388591734 no 1547 0.486299819411945 2310 669075
SGTC_2286 7945697 125 µM 0.034036355424669 0.468387215802393 no 1548 0.486424080024824 2305 1245733
SGTC_19 0279-0214 38.434 µM 0.0336357207132649 0.468572111399188 no 1549 0.48658381868236 2347 3566274 YBR002C RER2
SGTC_1764 st044502 93.5 µM 0.0329673962304812 0.468880562681194 no 1550 0.48685029377003 2314 8407
SGTC_1685 st024049 53.0905 µM 0.0325877214291384 0.469055802031041 no 1551 0.487001680755639 2300 1941139
SGTC_2885 9057732 51.95 µM 0.0314648990231508 0.469574076979805 no 1552 0.48744939239892 2316 6471414
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.030819486524852 0.469872011355971 no 1553 0.487706749900756 2336 688751
SGTC_818 4072-2707 53.5 µM 0.0304007795807786 0.470065303276471 no 1554 0.48787371156441 2349 882871
SGTC_2074 5212007 75.395 µM 0.0299692115177414 0.470264539787144 no 1555 0.488045803892849 2365 758611
SGTC_2448 5185112 27.17 µM 0.0298219943185374 0.470332505374848 no 1556 0.48810450881842 2308 5718189
SGTC_1754 st042065 16.137 µM 0.0297210352175883 0.470379115541539 no 1557 0.488144767826762 2316 1126236 YIL048W NEO1
SGTC_2047 4141938 200 µM 0.0296426086681856 0.470415323300776 no 1558 0.48817604171387 2320 3807862
SGTC_1064 honokiol 6.76 µM 0.0296130120629236 0.470428987445795 no 1559 0.48818784386992 2296 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_22 0964-0034 14.468 µM 0.0293165734963426 0.47056584896416 no 1560 0.488306054422434 2339 138402
SGTC_1991 st073000 8.92 µM 0.0288381008351624 0.470786760392598 no 1561 0.488496856717261 2336 4301969 YIL048W NEO1
SGTC_793 0488-0545 106 µM 0.0282522349951299 0.471057267623065 no 1562 0.4887304881642 2324 292548
SGTC_1789 tunicamycin 25 nM 0.0278960547944361 0.471221730443547 no 1563 0.488872527519218 2343 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_408 cantharidin 100 µM 0.0275151236771912 0.471397627195058 no 1564 0.489024438732201 2284 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_584 0986-0246 15.4 µM 0.0250387469767991 0.472541240397541 no 1565 0.490012028834777 2357 53315 YDR232W HEM1
SGTC_2557 derrustone 83.84 µM 0.0247939072132535 0.472654322071346 no 1566 0.49010967545278 2242 629853 An antioxidant.
SGTC_2902 5787006 60.46 µM 0.0245061829700719 0.472787213183787 no 1567 0.49022442595017 2344 591003
SGTC_2889 9059656 51.95 µM 0.0236667620200965 0.473174933549074 no 1568 0.490559209320605 2339 3949838
SGTC_203 k066-0004 30.888 µM 0.0235641932733194 0.473222310804567 no 1569 0.490600116921838 2359 6795412
SGTC_943 3253-1379 105 µM 0.0233733938611665 0.473310443457914 no 1570 0.490676213914907 2356 668464
SGTC_1534 6-azauridine 81.6 µM 0.0227813747833603 0.473583912828635 no 1571 0.490912332469711 2375 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1989 st071868 50.2 µM 0.022442421143254 0.473740490150139 no 1572 0.491047520842013 2364 16414057
SGTC_1458 k015-0034 6.33 µM 0.0223906014969795 0.473764428240311 no 1573 0.491068188696414 2339 3598957
SGTC_1886 st057356 49.9 µM 0.0222283795550314 0.473839367292805 no 1574 0.491132889784493 2366 24207747
SGTC_577 r071-0003 38.6 µM 0.0218717215185328 0.474004130101381 no 1575 0.491275141168292 2367 4568517 YMR134W ERG29
SGTC_2254 7938975 95.19 µM 0.0218066125725686 0.474034208504745 no 1576 0.491301109686095 2362 2969277
SGTC_519 k048-0011 62.8 µM 0.0215322988386684 0.474160934943341 no 1577 0.491410519341794 2293 6836379
SGTC_197 4544-0043 41.561 µM 0.0215285529436468 0.474162665476117 no 1578 0.491412013391366 2365 896523
SGTC_2529 gangaleoidin 93.61 µM 0.0215082468018053 0.474172046538744 no 1579 0.49142011249457 2366 4565183
SGTC_1757 st041620 31.8375 µM 0.0213443255069428 0.474247775674551 no 1580 0.491485492620412 2335 5289815
SGTC_1620 st003704 16.5 µM 0.0209830503332975 0.474414682571125 no 1581 0.491629588287295 2357 2834414
SGTC_1682 st012968 530 nM 0.0209019744285938 0.474452139755856 no 1582 0.49166192580138 2356 24207270
SGTC_2028 5153890 36.43 µM 0.0200223252513591 0.47485855339031 no 1583 0.492012781579518 2364 2830968 YPR165W RHO1
SGTC_98 0074-0023 107.663 µM 0.0191655901951734 0.475254405444511 no 1584 0.492354503802246 2334 3563821
SGTC_1929 genistein trimethyl ether 50.5 µM 0.0186227444183246 0.475505238495886 no 1585 0.492571029279594 2388 136420
SGTC_1653 st012112 65 µM 0.0181388151512412 0.475728856150475 no 1586 0.492764056512898 2360 720429
SGTC_2786 7743617 45.45 µM 0.017881293088641 0.47584785699194 no 1587 0.492866776290972 2353 583674
SGTC_1046 2001-0062 216 µM 0.0172044695203197 0.476160627134421 no 1588 0.493136748278097 2363 739778
SGTC_2657 nystatin 74.44 µM 0.0169209129141537 0.476291667196794 no 1589 0.493249854530988 2363 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2872 9044037 25.97 µM 0.016525483966324 0.476474411121195 no 1590 0.493407585798616 2358 6465195
SGTC_1880 MG-132 525 µM 0.0165193958879746 0.476477224710509 no 1591 0.493410014258979 2371 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_223 busulfan 5 mM 0.0161103216356856 0.476666279974426 no 1592 0.493573189554897 2356 2478 A DNA alkylator.
SGTC_3114 9122766 49.47 µM 0.0152842427567795 0.47704807152403 no 1593 0.493902706737484 2308 17176985
SGTC_3342 9147791 14.508 µM 0.0149448940108868 0.477204915557455 no 1594 0.494038071836399 2381 1838168
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0128795443491645 0.478159577433773 no 1595 0.494861947259517 2373 6708760
SGTC_198 3454-2873 16.191 µM 0.0127704973846239 0.478209985495518 no 1596 0.494905447126599 2367 710957
SGTC_3080 9117754 49.47 µM 0.0119259023622096 0.47860041982702 no 1597 0.495242366093492 2395 9550191
SGTC_1846 st056244 14.8 µM 0.011685418465736 0.478711593055817 no 1598 0.495338298601857 2337 5393182
SGTC_293 4049-0273 38.5 µM 0.0111485911123933 0.478959768775754 no 1599 0.495552447770397 2374 1380311
SGTC_1803 st050068 52.4 µM 0.0108167127856261 0.479113200481518 no 1600 0.495684840081555 2383 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2703 st077852 53.4 µM 0.00959759526822634 0.479676840902578 no 1601 0.496171172238749 2380 6281836
SGTC_748 act1.228 77.9 µM 0.00908614688984885 0.479913313438665 no 1602 0.496375201715825 2389 4421505 YNR035C ARC35
SGTC_809 3998-0021 90 µM 0.00769173393659693 0.480558067874367 no 1603 0.496931472380222 2392 715485
SGTC_1876 myriocin 605 nM 0.00748674801569125 0.480652854442145 no 1604 0.497013247575796 2396 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2683 piperine 63.03 µM 0.0073979006177136 0.480693938286319 no 1605 0.497048691577738 2398 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2307 7538926 6.34 µM 0.00698295986589356 0.480885813368691 no 1606 0.497214224707037 2382 96582
SGTC_1922 5578187 25 µM 0.0056481852468234 0.481503063805318 no 1607 0.49774671207824 2394 1350412
SGTC_117 lucigenin 22.078 µM 0.00532165197777515 0.481654071988353 no 1608 0.497876978045145 2390 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2890 9046729 58.44 µM 0.0051276812276818 0.481743776715912 no 1609 0.497954360122235 2389 903329
SGTC_1334 1486-0610 236 µM 0.00465210695154305 0.481963717184993 no 1610 0.4981440845384 2367 3742339
SGTC_1772 st048439 82.2 µM 0.00462860315453662 0.481974587209637 no 1611 0.498153461095823 2389 2927068 YDL195W SEC31
SGTC_1509 1326-1131 80 µM 0.00460322178575061 0.481986325587815 no 1612 0.498163586689094 2380 768313
SGTC_1650 st011916 45.8 µM 0.0032141381317717 0.482628772683606 no 1613 0.498717746611945 2397 242528
SGTC_3029 9088683 49.47 µM 0.00206976257364971 0.483158076968975 no 1614 0.499174284788528 2397 25236615
SGTC_1712 st032288 53.4 µM 0.00165072128934478 0.483351902238243 no 1615 0.499341457783596 2402 2883011
SGTC_2436 5633522 8.09 µM 0.00108943676182738 0.48361152750306 no 1616 0.499565377699857 2402 5724242
SGTC_871 0574-0004 149 µM -0.00012630266085639 0.484173898181347 no 1617 0.499949612528591 2406 9551173
SGTC_2722 naftopidil 47.16 µM -0.000404889400806777 0.484302769920203 no 1618 0.499838472503545 2399 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3049 9092223 49.47 µM -0.000740227121741279 0.484457896329811 no 1619 0.499704692131006 2407 8623917
SGTC_280 3448-3607 3.04 µM -0.00111381854965517 0.484630721579873 no 1620 0.499555650779723 2399 626179
SGTC_518 1021-0119 62.6 µM -0.00117700904451076 0.48465995410301 no 1621 0.499530441436147 2411 1097762
SGTC_1149 3909-7961 23.3 µM -0.00171991114786265 0.484911109153424 no 1622 0.499313855062864 2406 735261
SGTC_1070 indatraline 8.81 µM -0.0021055944774324 0.485089535969432 no 1623 0.499159989958274 2410 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2977 9011197 71.43 µM -0.003178051878401 0.485585697338245 no 1624 0.498732142870626 2415 2704722
SGTC_213 1246-0773 967 nM -0.00423188834570976 0.486073265666445 no 1625 0.498311725852143 2429 6251622
SGTC_2953 9074162 66.49 µM -0.00507012802938647 0.486461100817225 no 1626 0.497977320227934 2415 16451992
SGTC_2690 usnic acid 100 µM -0.00514187640548967 0.486494297820272 no 1627 0.497948697140285 2422 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.00712893249770468 0.48741371816914 no 1628 0.497155991502106 2417 229346 A bile salt which induces apoptosis.
SGTC_2681 menadione 3.18 µM -0.00776964075968247 0.487710191442082 no 1629 0.496900392983291 2431 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1711 st032263 62.8 µM -0.0080718639954104 0.487850040783831 no 1630 0.496779827139006 2435 3958979
SGTC_2480 5767542 37.17 µM -0.00811232439889498 0.487868763352149 no 1631 0.496763686301851 2428 2867358
SGTC_2426 5582046 32.21 µM -0.00968021871909019 0.488594307908654 no 1632 0.496138211782045 2427 2251934
SGTC_3132 9126706 49.47 µM -0.0107063454277143 0.48906916958433 no 1633 0.495728867737473 2456 850858
SGTC_424 splitomicin 100 mM -0.0107490346939091 0.489088925278814 no 1634 0.495711838164208 2446 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_208 k072-0098 12.366 µM -0.0120862162621129 0.489707758087098 no 1635 0.49517841471007 2427 5948901
SGTC_2142 5622915 118.518 µM -0.0129716413080675 0.490117536711344 no 1636 0.494825208957807 2435 5322196
SGTC_1205 4161-2785 76 µM -0.013550940008013 0.490385644381663 no 1637 0.494594122537182 2477 3498106
SGTC_2460 5552655 174.22 µM -0.0147569938351738 0.490943837027462 no 1638 0.494113024894951 2472 5401989
SGTC_920 mycophenolic acid 780.421 nM -0.0151718791029577 0.491135860726231 no 1639 0.493947528152544 2438 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1433 4060-0023 7.6 µM -0.0170574008976583 0.492008572680979 no 1640 0.493195411561187 2452 3840627
SGTC_2912 7964298 10.93 µM -0.018389842125752 0.492625315140459 no 1641 0.49266392794163 2452 2975850
SGTC_542 3381-0244 89.3 µM -0.0185676665429327 0.492707625478569 no 1642 0.492592998374216 2442 1112843
SGTC_1160 4092-0570 10.5 µM -0.0187687359031989 0.492800695675387 no 1643 0.492512797281575 2434 4994975
SGTC_1139 k015-0024 46.9 µM -0.0207447268145517 0.493715354655666 no 1644 0.491724644923695 2437 2766652
SGTC_786 4544-0069 423 µM -0.0208216074443122 0.493750942339343 no 1645 0.491693980613234 2522 748821 YLR208W SEC13
SGTC_2362 9071156 126 µM -0.0212849616006278 0.493965427852691 no 1646 0.49150917001347 2459 653133
SGTC_1984 st072354 53.1 µM -0.0221318345573684 0.494357447751059 no 1647 0.491171396193091 2458 5762938
SGTC_114 0364-0001 490.298 µM -0.0223328607914151 0.494450504180499 no 1648 0.491091218146537 2461 4003655
SGTC_2099 5377090 177.372 µM -0.0225138941411822 0.494534306024563 no 1649 0.491019014443827 2469 2243829
SGTC_1133 3473-0247 50 µM -0.0226555408684231 0.49459987564169 no 1650 0.490962519985384 2491 711311
SGTC_329 k048-0121 21.3 µM -0.0235235632063796 0.495001694557332 no 1651 0.490616321481563 2482 6832902
SGTC_2308 7584454 197.62 µM -0.0250799977152449 0.495722200917597 no 1652 0.489995577337467 2456 893577
SGTC_1288 0973-0013 65.5 µM -0.0254119476461581 0.49587586942684 no 1653 0.489863190671306 2482 4315430
SGTC_2177 5811945 192 µM -0.0254907919160723 0.495912368640814 no 1654 0.489831746544443 2472 5343475
SGTC_1604 st002052 72.4 µM -0.0257104941039568 0.496014075097506 no 1655 0.48974412677017 2527 6254834 YHR062C RPP1
SGTC_1487 3970-0795 2.82 µM -0.0266648484461489 0.496455876070758 no 1656 0.489363525016625 2478 3765103
SGTC_546 peri-Naphthalide 147 µM -0.026834680538586 0.496534497218124 no 1657 0.489295796050527 2481 223824 A penicillin ester.
SGTC_410 α-linolenic acid 100 µM -0.0269474859553463 0.496586718820262 no 1658 0.48925080946887 2541 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_146 3448-8650 53.125 µM -0.0270190386929643 0.496619843134051 no 1659 0.489222274446577 2495 2891488 YIL048W NEO1
SGTC_50 0929-0078 56.389 µM -0.0271991103980548 0.496703204850243 no 1660 0.489150462622182 2544 1377751
SGTC_105 0111-0055 734.78 µM -0.0274812561997878 0.496833820651964 no 1661 0.489037944793595 2509 5179370
SGTC_1476 4112-3294 3.34 µM -0.0284613804062977 0.497287559205088 no 1662 0.488647084756524 2519 704369
SGTC_946 3434-1334 87.4 µM -0.0287431488012423 0.49741800169874 no 1663 0.488534721401915 2484 4047976
SGTC_2003 4023581 200 µM -0.0291298982344258 0.497597044796703 no 1664 0.488380495284067 2509 16641307
SGTC_2526 patulin 37.61 µM -0.0293324458007706 0.497690813051349 no 1665 0.488299725011111 2496 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3091 9116372 49.47 µM -0.0296206012075665 0.497824213191992 no 1666 0.488184817566809 2559 17169793
SGTC_1413 3910-0535 34.4 µM -0.029688116581501 0.497855469140906 no 1667 0.48815789466992 2485 2876951
SGTC_2943 9068529 45.32 µM -0.0308108455832959 0.498375233435517 no 1668 0.48771019550137 2453 3270634
SGTC_1040 k898-0338 155 µM -0.0312450263743747 0.49857623702304 no 1669 0.48753706578672 2459 20969351
SGTC_1098 clofazimine 15.1 µM -0.0315676526275621 0.498725596779411 no 1670 0.487408419995174 2529 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1263 0774-1208 64.8 µM -0.0322260267794325 0.499030391486861 no 1671 0.487145900293254 2471 906585
SGTC_2395 5646831 180.19 µM -0.0324438318269176 0.499131224597211 no 1672 0.487059054063904 2490 6808628
SGTC_1940 st075990 51.1 µM -0.0325798380735337 0.499194188882253 no 1673 0.487004824090415 2642 1084979
SGTC_575 k072-0246 11.9 µM -0.0329202286482708 0.499351773266826 no 1674 0.486869100704533 2469 6796779
SGTC_1826 st055655 41.6 µM -0.0329693074880781 0.499374494406533 no 1675 0.486849531702828 2495 676168
SGTC_547 1120-0019 610 nM -0.0331578029901477 0.499461758766229 no 1676 0.486774373969895 2466 3676939
SGTC_2926 9010726 65.15 µM -0.0333290381008078 0.499541032416549 no 1677 0.486706098781181 2506 2994293
SGTC_2247 cerulenin 830 nM -0.0343204308328234 0.5 no 1678 0.486310816508493 2543 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.0346666640745164 0.499839710480118 no 1679 0.486172771577884 2484 688801
SGTC_3310 9130229 44.1445 µM -0.0346829096971282 0.49983218953012 no 1680 0.486166294407207 2546 7761258
SGTC_1225 1216-0074 20.6 µM -0.0347469054478396 0.499802562544263 no 1681 0.486140779175639 2501 4241466
SGTC_1735 st034310 56.75 µM -0.0348856189095013 0.499738344819368 no 1682 0.486085474040797 2639 871153
SGTC_3238 9133470 49.47 µM -0.0351769049944887 0.499603493261985 no 1683 0.485969338987928 2472 3534688
SGTC_661 1304-0007 33.6 µM -0.0378732341604267 0.498355225688787 no 1684 0.48489437688947 2495 3117130
SGTC_763 3453-1109 128 µM -0.0383837982380004 0.498118861114462 no 1685 0.484690839297887 2466 1560353
SGTC_1472 k841-0093 193 µM -0.0387646776947602 0.497942534190209 no 1686 0.484539003385579 2546 X1472
SGTC_3326 9140064 16.379 µM -0.0391549926728475 0.497761839538876 no 1687 0.484383408370361 2484 1868434
SGTC_1176 0848-0131 83.3 µM -0.039243082783611 0.497721058660683 no 1688 0.484348292489978 2504 6769040
SGTC_1264 0783-0040 158 µM -0.0408735032685172 0.496966268363107 no 1689 0.483698370558977 2478 2855798
SGTC_2541 muurolladie-3-one 83.07 µM -0.0412954688463574 0.496770924388908 no 1690 0.483530172663824 2612 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2409 alverine citrate 63.97 µM -0.0413154005092158 0.496761697280076 no 1691 0.483522227861152 2740 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0428243730596126 0.496063143091701 no 1692 0.4829207674584 2562 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2942 9052777 62.25 µM -0.0432364852433252 0.49587236449774 no 1693 0.482756510626065 2498 6469503
SGTC_1134 3477-0009 42.5 µM -0.04326862339466 0.495857486861391 no 1694 0.482743701345985 2517 3973534
SGTC_2974 9094440 9.66 µM -0.0435259190329287 0.495738377825865 no 1695 0.48264115185 2672 25236134
SGTC_1959 st077091 55.8 µM -0.0445247626467149 0.495275990087323 no 1696 0.482243056904397 2476 821356 YKL052C ASK1
SGTC_3281 9140613 49.47 µM -0.0449671611005984 0.495071195634035 no 1697 0.482066742055069 2510 16013766
SGTC_3291 9121177 71.43 µM -0.0453746878718143 0.494882545077886 no 1698 0.481904328176956 2523 17015612
SGTC_3334 9142812 21.919 µM -0.0457404049799714 0.494713249845898 no 1699 0.481758579489138 2573 45283678
SGTC_2283 7944793 200 µM -0.0459807843918163 0.494601975589316 no 1700 0.481662782771181 2510 2970533
SGTC_497 capsazepine 133 µM -0.0463979957925141 0.494408844874843 no 1701 0.481496516960122 2498 2733484 A calcium channel blocker.
SGTC_3084 9116877 49.47 µM -0.046494132152763 0.49436434271817 no 1702 0.481458205447148 2480 27241325
SGTC_911 3456-4043 236 µM -0.0470071099626545 0.494126883098031 no 1703 0.481253780431982 2532 914281
SGTC_1468 k284-1086 134 µM -0.0481655735660828 0.493590633132297 no 1704 0.48079214332143 2501 15996457
SGTC_54 0159-0055 9 µM -0.0483155908873432 0.493521191308066 no 1705 0.480732364666786 2487 3319099
SGTC_960 1222-0186 7.7 µM -0.0485223467874735 0.493425485969374 no 1706 0.480649977627218 2543 3126296
SGTC_2333 9017922 200 µM -0.0487324351613891 0.493328238447942 no 1707 0.480566263527079 2535 3163164
SGTC_1949 st076024 69.1 µM -0.0489535286308474 0.493225897221136 no 1708 0.480478165142447 2480 2921930
SGTC_1756 st041558 35.5 µM -0.0490584123120545 0.493177348115415 no 1709 0.480436372821559 2505 3955792
SGTC_2064 5220758 200 µM -0.0492617227579298 0.493083239003657 no 1710 0.480355361638318 2574 788518
SGTC_1502 4534-4282 27.7 µM -0.0497829820694037 0.492841958284065 no 1711 0.480147664103782 2505 3278949
SGTC_2495 cafestol 54.53 µM -0.0535183296586739 0.491113021021739 no 1712 0.478659463310794 2669 16667697 An anti-infammatory.
SGTC_3329 9141233 27.5565 µM -0.0548432925452867 0.490499789164949 no 1713 0.478131654909433 2566 4909101 YNL103W MET4
SGTC_2874 9043904 71.43 µM -0.0562127036939095 0.489866008957559 no 1714 0.477586180540654 2573 4463428
SGTC_2795 7780010 54.55 µM -0.0563812199077086 0.489788019331043 no 1715 0.477519058748594 2570 953673
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0565005292214172 0.489732802988034 no 1716 0.47747153697128 2554 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1348 1493-0373 93.8 µM -0.0574778060376863 0.489280526840254 no 1717 0.477082292545829 2540 3010129
SGTC_580 1123-0028 41 µM -0.0577668749099602 0.489146750618482 no 1718 0.476967162045742 2514 1677248 YPR107C YTH1
SGTC_1398 3558-0053 112 µM -0.0583677229145197 0.488868692171635 no 1719 0.47672786215352 2515 4532369
SGTC_1324 1418-0026 34.4 µM -0.0586494400450527 0.488738321907057 no 1720 0.476615665482708 2601 1372513
SGTC_2502 avocadyne acetate 18.59 µM -0.0598939825806519 0.488162399423135 no 1721 0.47612003624891 2497 3952079
SGTC_975 1335-0046 28.5 µM -0.0602102194295205 0.488016062057546 no 1722 0.475994103277836 2540 16486740
SGTC_884 0851-0618 334 µM -0.0616985415481066 0.487327368806958 no 1723 0.475401450717241 2520 9642473
SGTC_931 2812-0076 566 µM -0.0621512191565082 0.487117908102449 no 1724 0.475221204407352 2505 3450959
SGTC_2027 5150920 200 µM -0.0624999494607313 0.486956547791587 no 1725 0.475082351093663 2579 786715
SGTC_720 r052-1644 49.9 µM -0.0638425524957143 0.486335334760923 no 1726 0.474547797678369 2573 1422863 YOR257W CDC31
SGTC_559 1550-0661 158 µM -0.0655430493544524 0.485548574547169 no 1727 0.473870815786629 2585 5830875
SGTC_1453 4237-0541 195 µM -0.0674818955632438 0.484651607258193 no 1728 0.473099037207909 2522 739892
SGTC_451 chloral hydrate 100 µM -0.0677678850108484 0.484519306590397 no 1729 0.472985204509329 2615 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2396 5342950 42.78 µM -0.067997262003724 0.484413196460917 no 1730 0.472893906923071 2575 1886677
SGTC_2345 9052315 157.45 µM -0.0680987413195063 0.484366252334044 no 1731 0.472853516157114 2582 6469265
SGTC_97 0535-0701 19.132 µM -0.0686466077608513 0.484112814182326 no 1732 0.47263545935694 2550 2832013 YGL099W LSG1
SGTC_971 1315-0384 26.7 µM -0.0687755627810585 0.484053161664224 no 1733 0.472584135046765 2571 6769120
SGTC_1716 st033144 30.6155 µM -0.0695804654681672 0.483680834747305 no 1734 0.472263792774296 2547 674617
SGTC_2798 7813637 45.45 µM -0.0696378033262968 0.483654312293901 no 1735 0.472240973629749 2599 956368
SGTC_831 k061-1017 217 µM -0.0702715502191153 0.483361168370282 no 1736 0.471988763074894 2599 1240153
SGTC_2618 avocadyne 43.43 µM -0.0703873222750437 0.48330761818752 no 1737 0.471942690789983 2551 3015189
SGTC_2659 sanguinarine 24.21 µM -0.0704208179702698 0.483292124862385 no 1738 0.471929361017979 2529 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2727 riluzole 51.77 µM -0.0705832293020829 0.483217002386029 no 1739 0.47186472909836 2537 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_176 1486-1328 72.834 µM -0.0711471383611972 0.482956173966843 no 1740 0.471640326105155 2590 22310231
SGTC_2958 9077254 16.72 µM -0.071954694146387 0.482582662818655 no 1741 0.471318981588087 2633 16457351
SGTC_701 4424-0219 185 µM -0.0735125570821325 0.481862162667098 no 1742 0.470699126002688 2553 2911779
SGTC_2346 9031566 143.75 µM -0.0739571067016942 0.481656572498339 no 1743 0.470522257819978 2619 4771086
SGTC_462 ag-879 158 µM -0.0757322803875993 0.480835659870932 no 1744 0.469816046847667 2536 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3052 9092717 49.47 µM -0.0759510854695103 0.480734481042789 no 1745 0.469729006934895 2638 25237534
SGTC_1529 apigenin 74 µM -0.0762669560277498 0.480588419839405 no 1746 0.469603357260203 2585 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2284 7945075 39.21 µM -0.076432649612635 0.480511802772698 no 1747 0.469537447467632 2607 1245402
SGTC_3074 9116018 49.47 µM -0.0765777266261204 0.480444719443575 no 1748 0.46947973924483 2538 17027303
SGTC_1174 0739-0097 51.1 µM -0.0770366803216834 0.480232503802847 no 1749 0.469297182490252 2577 728447
SGTC_2447 5741742 33.78 µM -0.0776039371114913 0.479970217632791 no 1750 0.469071555233407 2612 1776504
SGTC_1540 guanosine 70.6 µM -0.0778091351771698 0.479875341013444 no 1751 0.468989939831019 2523 6802 Guanosine is a purine nucleoside
SGTC_446 go6976 132 µM -0.077913300694746 0.479827178850362 no 1752 0.468948509575196 2556 3501 A protein kinase C inhibitor.
SGTC_2412 st077135 33.4 µM -0.0793180619366257 0.479177699873239 no 1753 0.468389820107339 2830 13258915
SGTC_766 1391-0721 126 µM -0.0795051985135225 0.479091183061821 no 1754 0.468315398444262 2585 1020919 YIL115C NUP159
SGTC_732 3970-1727 52.7 µM -0.0798605428449809 0.478926903309568 no 1755 0.468174085902046 2596 1275699
SGTC_2310 7668677 200 µM -0.0800535647564112 0.478837668568968 no 1756 0.468097327057884 2622 2197143
SGTC_1375 2910-0797 186 µM -0.0800865529192464 0.478822418125799 no 1757 0.468084208804417 2599 742508
SGTC_2057 5236571 38.335 µM -0.0802743450400778 0.478735602331468 no 1758 0.468009531021988 2568 54684039 YBR257W POP4
SGTC_159 3970-0959 50 µM -0.0809013678659639 0.478445738690317 no 1759 0.467760196066785 2618 6615653
SGTC_3148 9097893 49.47 µM -0.0829397502567968 0.477503503372592 no 1760 0.466949723387244 2584 17174100
SGTC_1546 5-methoxyflavanone 78.7 µM -0.083403434888076 0.477289184096983 no 1761 0.466765378692117 2591 147795
SGTC_1664 st014217 9.02 µM -0.0837327761314724 0.477136963549305 no 1762 0.46663444852896 2566 3982782
SGTC_3217 9129673 49.47 µM -0.0839968334873643 0.477014919429592 no 1763 0.466529474691939 2646 17248312
SGTC_1203 3992-3522 103 µM -0.0840833569156416 0.47697492981474 no 1764 0.466495078518461 2660 5322312
SGTC_977 1348-1378 135 µM -0.0850159918992316 0.476543897044136 no 1765 0.466124338520554 2546 X977
SGTC_1733 st037357 54.9 µM -0.0860135114236282 0.476082907189872 no 1766 0.465727838235039 2556 1272339 YGL099W LSG1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0865702792461767 0.475825618519616 no 1767 0.465506545454013 2663 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1759 st043059 70 µM -0.0876756727413281 0.475314833732322 no 1768 0.465067227743898 2585 669426
SGTC_1041 0206-0046 107 µM -0.0882507413679998 0.475049119637283 no 1769 0.464838694411475 2662 50494
SGTC_1207 2099-0101 141 µM -0.0885358115515031 0.474917405263163 no 1770 0.464725411289924 2629 5837381
SGTC_1605 st000082 49.1 µM -0.0889275875463774 0.4747363928068 no 1771 0.464569729356433 2694 1114022
SGTC_1939 st074455 53.6 µM -0.0889815335963838 0.474711468494309 no 1772 0.464548292976341 2596 1644229
SGTC_3058 9093861 49.47 µM -0.0893383847256178 0.474546597584661 no 1773 0.464406494707973 2640 17217477
SGTC_3170 9103054 49.47 µM -0.0898681229216697 0.474301858141097 no 1774 0.464196006422958 2625 16432970
SGTC_2206 7254556 146.969 µM -0.0902783125295313 0.474112356892065 no 1775 0.464033026930693 2605 4398905
SGTC_1426 4048-4480 71.7 µM -0.0903969346630973 0.47405755639263 no 1776 0.463985896253196 2582 14224343
SGTC_1881 5652484 16 µM -0.0904347292773224 0.474040096316276 no 1777 0.463970879888787 2571 2255129
SGTC_2320 7373003 200 µM -0.0921760375287967 0.473235714227657 no 1778 0.463279088130257 2603 5415828
SGTC_1878 temozolomide 1 mM -0.0926063573813347 0.473036948431206 no 1779 0.463108146497771 2549 5394 DNA alkylating agent.
SGTC_2279 7948423 32.93 µM -0.0936122048864108 0.472572371270581 no 1780 0.462708607047419 2561 1247112
SGTC_1108 betulinic acid 729.144 nM -0.0941496426786759 0.472324156725211 no 1781 0.462495143162958 2576 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_201 4262-0159 12.803 µM -0.0943790296567226 0.472218218085458 no 1782 0.462404036674983 2653 1341029
SGTC_1291 0993-0025 5.79 µM -0.0948955766991952 0.471979666454353 no 1783 0.462198884974067 2653 4353356
SGTC_2056 5235370 200 µM -0.0949758017781247 0.471942617827291 no 1784 0.462167023701542 2620 5511916
SGTC_3306 9127676 59.7925 µM -0.0950946538762446 0.471887731359002 no 1785 0.462119822211248 2631 41905287
SGTC_2137 5261020 140 µM -0.0952614982303239 0.471810682738005 no 1786 0.462053561747293 2575 763655
SGTC_1345 1488-0192 31.4 µM -0.0961063675328523 0.471420538865777 no 1787 0.461718047079839 2595 658348
SGTC_2661 dactinomycin 12.96 µM -0.096188093115337 0.471382801062902 no 1788 0.461685593641307 2585 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2675 theaflavin digallate 100 µM -0.0963788988512389 0.471294695145076 no 1789 0.461609825187417 2598 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3104 9120930 49.47 µM -0.0966079072060951 0.471188950749167 no 1790 0.461518888414384 2649 17014836
SGTC_3047 9092122 49.47 µM -0.0978415073546777 0.470619372149484 no 1791 0.461029073690348 2631 17173831
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0981371521761053 0.470482875729495 no 1792 0.460911693364041 2621 4330530
SGTC_367 0335-0881 7.1 µM -0.0985759131569948 0.470280310328431 no 1793 0.460737497685401 2675 23828853
SGTC_1000 4048-0884 8.67 µM -0.0986222837609807 0.470258902583316 no 1794 0.460719088195276 2695 13040088
SGTC_1157 4092-0394 27.6 µM -0.0992325057575526 0.469977191684608 no 1795 0.460476833179266 2744 3659885
SGTC_3224 9130643 49.47 µM -0.0996655600922079 0.469777279900258 no 1796 0.460304921713855 2686 17644395
SGTC_3313 9133968 57.047 µM -0.100452796927094 0.469413885649184 no 1797 0.459992427904613 2570 1494643
SGTC_1928 4'-methoxychalcone 40.3 µM -0.100470182680616 0.469405860545274 no 1798 0.459985526904678 2763 641818
SGTC_3152 9099253 49.47 µM -0.10071550231804 0.469292624583613 no 1799 0.459888152439954 2656 25236131
SGTC_2435 5706476 10.6 µM -0.102232743820551 0.468592343599036 no 1800 0.459285969047736 2622 5725375
SGTC_2008 4012253 172 µM -0.10499269836746 0.467318740544604 no 1801 0.458190801277993 2608 603940
SGTC_621 3584-0052 32.1 µM -0.105003866892822 0.467313587410196 no 1802 0.458186370174122 2590 2273927
SGTC_1422 4031-0024 15.5 µM -0.106048594205174 0.466831576738839 no 1803 0.457771898467005 2586 782427
SGTC_9 0092-0002 10.449 µM -0.1061152227101 0.466800837679855 no 1804 0.457745466681857 2609 759368
SGTC_1357 1503-1303 39.5 µM -0.10651776849034 0.466615127413372 no 1805 0.457585779196034 2605 292895
SGTC_2505 galangin 7.89 µM -0.10666983301696 0.466544975930815 no 1806 0.457525457894859 2572 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2893 9048488 25.97 µM -0.107696172319013 0.466071525116139 no 1807 0.457118352950728 2629 6467338
SGTC_1891 st059073 26.2 µM -0.109293505618378 0.46533477024976 no 1808 0.45648484875264 2644 688754
SGTC_1170 0310-0127 64.8 µM -0.109902709627474 0.46505381182632 no 1809 0.456243266795916 2682 774975
SGTC_1121 fusaric acid 630.51 nM -0.11016947448988 0.464930788179124 no 1810 0.456137485353839 2635 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2251 lansoprazole 556 µM -0.110978978475137 0.464557490718003 no 1811 0.455816508245739 2617 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3343 9148379 18.9835 µM -0.111041897036343 0.464528477537859 no 1812 0.455791561558962 2690 1955036
SGTC_1778 st046819 58.9 µM -0.111197871699068 0.464456554885628 no 1813 0.455729719652851 2616 671715
SGTC_2306 7482397 179.52 µM -0.111983568401959 0.464094274065121 no 1814 0.455418217565002 2688 891448
SGTC_2755 lomerizine 42.69 µM -0.112552477770123 0.463831971364253 no 1815 0.45519268139668 2651 3949 A calcium channel blocker.
SGTC_1856 st057054 55.7 µM -0.11290814618072 0.463667994023437 no 1816 0.455051688957534 2808 1266018
SGTC_1596 piperlongumine 63 µM -0.113034594913169 0.463609697593863 no 1817 0.455001564094667 2736 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1492 4158-0558 28.5 µM -0.113760103371324 0.463275232887335 no 1818 0.454713983055355 2717 3967268
SGTC_1836 st055642 81 µM -0.114837956307501 0.462778382797622 no 1819 0.454286781638508 2622 8571
SGTC_3137 9097352 49.47 µM -0.115364772677178 0.462535561134746 no 1820 0.454077999911778 2829 44120435
SGTC_1800 st050079 29.0735 µM -0.115925016357989 0.462277347382585 no 1821 0.45385598458557 2662 3645560
SGTC_1884 5633444 25 µM -0.115941785418205 0.462269618843859 no 1822 0.453849339505613 2733 5724239
SGTC_2583 asiatic acid 100 µM -0.116552012773535 0.461988386455942 no 1823 0.453607533353196 2734 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1371 2421-0008 32.7 µM -0.117175524862003 0.46170105123002 no 1824 0.453360480811456 2671 2827552
SGTC_2123 5259487 200 µM -0.117490268731389 0.461556014309827 no 1825 0.453235777531714 2695 2173474
SGTC_2397 5161689 200 µM -0.118308638059261 0.461178926042605 no 1826 0.452911556644394 2738 2259942
SGTC_1663 st014140 55.4 µM -0.118897150410578 0.460907772840968 no 1827 0.452678419695689 2618 4207120
SGTC_3199 9111318 49.47 µM -0.119168973261302 0.460782538375537 no 1828 0.452570743600852 2702 8548020
SGTC_3354 9151612 71.43 µM -0.119331893543975 0.460707479461539 no 1829 0.452506208314425 2716 27261949
SGTC_1432 4049-0298 68.4 µM -0.120438062452542 0.460197894146491 no 1830 0.452068070676341 2693 741646
SGTC_817 1391-0715 46 µM -0.121991226160344 0.459482499630658 no 1831 0.451452983440732 2682 1353946
SGTC_2837 9008476 45.46 µM -0.122038611587954 0.459460675729894 no 1832 0.451434219586095 2813 2992805
SGTC_2516 gossypol 71.55 µM -0.122156765398494 0.459406259172983 no 1833 0.451387433081486 2721 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1892 st058411 7.36 µM -0.122461239423267 0.459266035056598 no 1834 0.4512668706773 2737 3934738
SGTC_342 k048-0088 23.3 µM -0.123812235764119 0.458643901252175 no 1835 0.450731971811409 2604 6820570
SGTC_609 0986-0026 86.3 µM -0.123996613617329 0.45855900307303 no 1836 0.450658978156801 2630 2848610
SGTC_3118 9124250 49.47 µM -0.124370864647128 0.458386682168128 no 1837 0.450510820428884 2696 1504786
SGTC_31 0508-1974 57.237 µM -0.12480759415431 0.458185603436089 no 1838 0.450337937570207 2647 6810525
SGTC_1220 1838-0075 193 µM -0.125146820164632 0.458029424585455 no 1839 0.450203658749024 2660 5529645
SGTC_228 caffeine 993.056 µM -0.127282875688273 0.457046139525009 no 1840 0.44935825664261 2754 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2776 terbinafine 19.92 µM -0.127490319339697 0.456950661421248 no 1841 0.449276167354373 2612 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2055 5235184 200 µM -0.127977318969709 0.456726524537582 no 1842 0.449083461133776 2753 2836034
SGTC_32 0928-0142 34.1 µM -0.128757981821424 0.456367260738616 no 1843 0.448774577170288 2636 2244242
SGTC_2766 oltipraz 83.91 µM -0.128853100635748 0.456323489156381 no 1844 0.448736943737698 2713 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.128944659057281 0.456281356489072 no 1845 0.44870071939797 2733 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2854 9024559 71.43 µM -0.128978381759191 0.456265838353024 no 1846 0.448687377394857 2717 3163529
SGTC_965 1291-5240 308 µM -0.129406742326185 0.456068725988358 no 1847 0.448517906468294 2716 2834598
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.131027584943268 0.455322984998968 no 1848 0.447876742944737 2643 688669
SGTC_1287 0971-0001 34.6 µM -0.131194428945713 0.455246229859438 no 1849 0.447810751462522 2633 4665869
SGTC_2752 diclazuril 33.15 µM -0.131750351865049 0.454990494403926 no 1850 0.447590878791708 2737 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3028 9087778 49.47 µM -0.132134088613111 0.454813978842107 no 1851 0.447439116738993 2651 17217395
SGTC_648 0375-0473 33.3 µM -0.132545702141212 0.454624650122854 no 1852 0.447276338397627 2658 1713139
SGTC_827 3253-0474 693 µM -0.136276863433383 0.452908913776435 no 1853 0.44580120677082 2679 5402065
SGTC_744 1594-0068 283 µM -0.136419617491858 0.4528432870343 no 1854 0.44574478306854 2677 668392
SGTC_1322 1348-1070 12 µM -0.137654712683404 0.45227554437288 no 1855 0.445256656303578 2646 6758089
SGTC_2163 5671233 125 µM -0.138567629632986 0.451855961715171 no 1856 0.444895912147889 2709 701023
SGTC_942 3253-1115 227 µM -0.138895403771074 0.451705327651427 no 1857 0.444766401511332 2793 46497897
SGTC_99 0109-0120 622.8 µM -0.139603039792541 0.45138014547032 no 1858 0.44448681936864 2666 759414
SGTC_979 1426-2828 121 µM -0.140159480156275 0.45112446560127 no 1859 0.44426699298433 2758 747872
SGTC_471 1-acyl-paf 4 µM -0.140935524241122 0.450767913472028 no 1860 0.443960438969498 2637 16759367
SGTC_2179 6298986 200 µM -0.14134483184268 0.450579873776689 no 1861 0.44379876720408 2739 738374
SGTC_291 SEC14.278 35.5 µM -0.141593523935851 0.45046562774505 no 1862 0.44370054127169 2715 1068044
SGTC_2079 5212404 121 µM -0.141824896914891 0.450359341582758 no 1863 0.443609158976688 2689 758462
SGTC_2364 9055074 200 µM -0.142062745053423 0.45025008462747 no 1864 0.443515222400142 2736 6470630
SGTC_1034 k072-0165 12.7 µM -0.142859655381943 0.449884046659971 no 1865 0.443200511007415 2797 5835461
SGTC_2256 7954252 200 µM -0.142910872999584 0.449860522766943 no 1866 0.443180285654045 2740 2972920
SGTC_601 0986-0029 62.9 µM -0.142911552891831 0.449860210498381 no 1867 0.443180017172015 2670 24747981
SGTC_332 4112-0506 40.9 µM -0.143020755903604 0.449810054913378 no 1868 0.443136894432845 2669 2790355
SGTC_1388 3346-4487 254 µM -0.143426483171623 0.449623716454948 no 1869 0.442976684323414 2729 3345614
SGTC_2596 sinensetin 100 µM -0.143672599869921 0.449510687790731 no 1870 0.442879504410226 2710 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1615 st002656 86.5 µM -0.145319343650177 0.448754529424372 no 1871 0.442229371406049 2637 1584458
SGTC_179 1273-0063 6.77 µM -0.145995571798255 0.44844407003896 no 1872 0.441962442082671 2683 3108139
SGTC_1491 4138-0063 26.5 µM -0.146171243614027 0.448363423476388 no 1873 0.441893102989943 2646 23883227
SGTC_3275 9138069 49.47 µM -0.146268250484979 0.448318890948303 no 1874 0.441854814352879 2745 17617007
SGTC_3098 9119039 49.47 µM -0.14682767945224 0.448062089016593 no 1875 0.441634018206076 2645 17161528
SGTC_1233 0325-0408 14.2 µM -0.147388610665756 0.447804619342115 no 1876 0.441412647359332 2747 12874
SGTC_600 1495-0418 41.6 µM -0.147677927959113 0.447671830134197 no 1877 0.441298475777876 2681 5377768
SGTC_1296 1068-0102 11.9 µM -0.147681966168718 0.447669976741155 no 1878 0.441296882237472 2771 767053
SGTC_2949 9072542 2.23 µM -0.148273724575411 0.447398393277351 no 1879 0.441063375440459 2757 16457352
SGTC_904 1141-0088 396 µM -0.149662784996571 0.446760990626639 no 1880 0.440515335340553 2714 1378119
SGTC_341 1486-1430 230 µM -0.150393701161822 0.446425647872227 no 1881 0.440227005248626 2663 2054753 YPL210C SRP72
SGTC_1169 aniline yellow 25.8 µM -0.150543276749871 0.446357027630599 no 1882 0.440168004923557 2719 6051 A DNA damaging agent.
SGTC_1184 1269-1718 139 µM -0.151526736430647 0.445905889552682 no 1883 0.439780110855396 2809 5403821
SGTC_936 3005-4620 401 µM -0.15302537227368 0.445218561852948 no 1884 0.439189133375058 2844 777207
SGTC_1462 k081-0014 26.5 µM -0.153245177163522 0.445117765308427 no 1885 0.439102466083974 2700 3270634
SGTC_172 1112-0046 2.638 µM -0.154347246906678 0.444612439719326 no 1886 0.438667972987788 2741 2802135 YIL048W NEO1
SGTC_3110 9122132 49.47 µM -0.154350166502959 0.444611101133111 no 1887 0.438666822029313 2823 918317
SGTC_1847 st056231 15 µM -0.154556830408486 0.444516350784068 no 1888 0.438585352640492 2676 5393180
SGTC_3043 9092303 49.47 µM -0.155434601104017 0.444113949771301 no 1889 0.438239353949353 2704 25236084
SGTC_475 α-linolenic acid 10 µM -0.156134365573253 0.443793194330718 no 1890 0.43796355536012 2916 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_740 k014-0057 261 µM -0.156282775557835 0.44372517143796 no 1891 0.437905066312463 2799 4012779
SGTC_70 0141-0289 43.283 µM -0.157103718804817 0.443348926663191 no 1892 0.437581553398418 2801 352408
SGTC_2718 lomofungin 53.02 µM -0.15773964075439 0.443057513693714 no 1893 0.437330981351219 2806 5351222 A RNA synthesis inhibitor.
SGTC_2053 5265679 138 µM -0.157861255232377 0.443001787030528 no 1894 0.437283064511605 2689 764595
SGTC_387 norethindrone acetate 66.7 µM -0.158784273720491 0.442578874707777 no 1895 0.436919419682135 2746 541197
SGTC_986 1493-0483 84 µM -0.159793902528876 0.442116353855251 no 1896 0.436521713719684 2678 40079
SGTC_170 4197-0004 226 µM -0.160705070469886 0.441699006604653 no 1897 0.436162847844346 2840 218692
SGTC_2757 clomiphene 4.22 µM -0.161544885042686 0.441314399030444 no 1898 0.43583213120649 2849 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3045 9092950 49.47 µM -0.163035662344757 0.440631808363232 no 1899 0.435245177910759 2722 44120432
SGTC_2807 7945238 51.95 µM -0.166839328958555 0.438891005648923 no 1900 0.433748236163767 2809 17148797
SGTC_338 4055-0136 114 µM -0.167258504047711 0.438699235802246 no 1901 0.433583326555361 2700 2900563
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.16776361671511 0.438468169200411 no 1902 0.433384623209745 2700 17037758
SGTC_107 0358-0022 2.6945 µM -0.168003651527701 0.438358371285595 no 1903 0.433290203204332 2770 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3135 9127742 49.47 µM -0.168024976256697 0.438348617051614 no 1904 0.433281815100875 2777 3643468
SGTC_1591 genipin 88.4 µM -0.16886807127645 0.437963003483494 no 1905 0.432950206954384 2857 442424 A DNA cross-linking agent.
SGTC_995 3931-2021 34.6 µM -0.169462319102674 0.437691242648906 no 1906 0.432716504330493 2817 730143
SGTC_1569 carminic acid 40.6 µM -0.170053024096228 0.437421131144789 no 1907 0.432484218336073 2801 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_288 1315-0019 35.1 µM -0.170072624234188 0.43741216909448 no 1908 0.432476511271466 2760 6811474
SGTC_729 4092-0585 94.1 µM -0.170531903054682 0.437202175698224 no 1909 0.432295923395736 2706 2169061
SGTC_371 0195-0006 7.36 µM -0.170748207195083 0.43710328233238 no 1910 0.432210877766635 2673 3928593
SGTC_2180 6301957 200 µM -0.171072102997466 0.436955205850003 no 1911 0.432083535536396 2742 845462
SGTC_1635 st007035 42.4 µM -0.172213218435167 0.436433588954571 no 1912 0.431634953162575 2695 3716403
SGTC_1935 st074532 41.6 µM -0.172217951526376 0.436431425634073 no 1913 0.431633092726546 2845 2829742
SGTC_1258 0671-0043 57.1 µM -0.173056504784166 0.436048184100425 no 1914 0.431303506592902 2786 4298767
SGTC_772 k072-0172 35.3 µM -0.173389456836545 0.435896032632891 no 1915 0.431172655909136 2739 5861980
SGTC_2487 5918373 44.05 µM -0.173687717412318 0.435759742431257 no 1916 0.431055445444441 2699 2876279
SGTC_2497 7-hydroxyflavone 100 µM -0.173813098068817 0.435702452003651 no 1917 0.431006175156239 2889 5281894
SGTC_2679 rapamycin 1 nM -0.174229858466254 0.4355120305666 no 1918 0.430842410366 2768 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2875 9039966 71.43 µM -0.174651740770201 0.43531928411452 no 1919 0.430676645048536 2820 6463691
SGTC_805 3852-0218 479 µM -0.175177927196883 0.435078905509589 no 1920 0.430469913842201 2720 6615355
SGTC_845 0330-0138 4.51 µM -0.175847417137547 0.43477309601895 no 1921 0.430206908264611 2797 9039800
SGTC_1798 st045719 60.953 µM -0.177977989350405 0.433800154168774 no 1922 0.429370130853605 2717 3980186
SGTC_3124 9127567 49.47 µM -0.178127909368556 0.433731707094432 no 1923 0.429311262010035 2910 17592030
SGTC_1344 1488-0097 29.1 µM -0.179893696435556 0.432925674255532 no 1924 0.428618011994056 2819 747966
SGTC_2978 9011784 42.97 µM -0.181756651329279 0.432075589477011 no 1925 0.427886852506025 2873 2994934
SGTC_3283 9109332 35.8195 µM -0.182272656010875 0.431840186859668 no 1926 0.427684378274384 2693 17027281
SGTC_1273 0849-0096 14.1 µM -0.182501185673224 0.431735938787511 no 1927 0.427594711975837 2769 5286025
SGTC_2706 st078239 82.5 µM -0.183179855709746 0.431426378828544 no 1928 0.427328449872472 2732 15434492
SGTC_721 1187-1332 279 µM -0.183940408723395 0.431079519853389 no 1929 0.427030102018592 2694 25730
SGTC_270 tamoxifen 5.46 µM -0.184086115257942 0.431013074765908 no 1930 0.426972949378377 2907 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1063 disulfiram 1.84 µM -0.184665787806993 0.430748751869387 no 1931 0.426745590988835 2716 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2561 acetosyringone 100 µM -0.185653820932719 0.430298293592457 no 1932 0.426358122093222 2725 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_537 1334-0398 209 µM -0.186046093976877 0.430119475882571 no 1933 0.42620430726023 2843 5846986
SGTC_130 0136-0219 337.655 µM -0.186881790306031 0.429738571453434 no 1934 0.425876658447363 2708 234244
SGTC_1078 idebenone 36.1 µM -0.187597884135977 0.429412233001211 no 1935 0.42559594250588 2808 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2379 9035213 200 µM -0.188285355933892 0.429098983564544 no 1936 0.425326482162942 2853 646551
SGTC_1510 1123-0200 71.5 µM -0.188387137775019 0.429052610027193 no 1937 0.425286590876876 2946 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1843 st055809 45.5 µM -0.188387820658036 0.429052298897386 no 1938 0.425286323237594 2876 16413835
SGTC_573 3702-0553 84.7 µM -0.188620708848831 0.428946194777817 no 1939 0.425195050420983 2760 1222756
SGTC_2242 6630449 61.2675 µM -0.189167291111292 0.428697191468378 no 1940 0.424980851353296 2932 691249 YDR170C SEC7
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.190470050178834 0.428103815687895 no 1941 0.424470405028919 2758 6708561
SGTC_688 0527-0193 473 µM -0.191697291838971 0.427544984936791 no 1942 0.423989663723423 2800 4007154
SGTC_2922 7999257 32.47 µM -0.19239871957722 0.427225651435005 no 1943 0.423714947647618 2730 2988377
SGTC_2110 5483698 200 µM -0.193809116576553 0.426583695588858 no 1944 0.423162674183858 2801 2848765 YHR062C RPP1
SGTC_697 0508-1955 564 µM -0.193902680921215 0.426541115730429 no 1945 0.423126042234624 2851 6243113
SGTC_632 0781-2353 4.65 µM -0.19446267410783 0.426286288374317 no 1946 0.422906809777487 2836 6811515 YHR007C ERG11
SGTC_1454 4239-0054 42.6 µM -0.195167859855659 0.425965434293562 no 1947 0.422630769664257 2938 1340767
SGTC_459 nigericin 15.3 µM -0.197059576000938 0.425104960658052 no 1948 0.421890458390715 2861 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_132 0417-1715 25.805 µM -0.197341956445449 0.424976546445742 no 1949 0.421779974177022 2814 6769098
SGTC_556 4058-0063 51.5 µM -0.197792531895394 0.424771661029105 no 1950 0.421603694713937 2759 6615692
SGTC_52 0329-0193 875 nM -0.19823145572538 0.424572093370063 no 1951 0.421431988840606 2968 3739292
SGTC_1452 4194-0072 190 µM -0.198752148306022 0.424335372586596 no 1952 0.421228314617978 2935 1343545
SGTC_652 0437-0092 114 µM -0.198824668322521 0.424302405209448 no 1953 0.421199949343587 2761 3091274
SGTC_639 0833-0042 114 µM -0.199204807011656 0.424129603996451 no 1954 0.421051269664702 2773 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1997 st073024 93.8 µM -0.199863416639104 0.423830251642782 no 1955 0.420793701215625 2845 686268
SGTC_1969 st069479 40.1 µM -0.201595615001512 0.423043140168004 no 1956 0.420116436785239 2946 3895485
SGTC_1386 3228-0095 33.8 µM -0.201877186335265 0.422915222999542 no 1957 0.420006368769754 2908 870181
SGTC_2266 7929956 200 µM -0.20224972365683 0.422745992696503 no 1958 0.419860751190334 2737 2967153
SGTC_955 1216-0110 33 µM -0.203379373000047 0.422232920923242 no 1959 0.419419260429476 2731 3619719
SGTC_1899 st063254 59.6 µM -0.203654997307501 0.422107756002577 no 1960 0.419311556014673 2742 3093813
SGTC_2231 micatex 6.853 µM -0.20393310488202 0.421981471368223 no 1961 0.419202887352768 2790 20737 An antifungal of unknown mechanism.
SGTC_2261 9010538 184.68 µM -0.204733822820219 0.42161792175286 no 1962 0.418890046655381 2897 6457250
SGTC_1100 amiodarone 5.07 µM -0.205497368972457 0.421271311440858 no 1963 0.418591776746592 2872 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2684 capsaicin 100 µM -0.206131537277812 0.420983478315513 no 1964 0.418344082269061 2859 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1278 0874-0585 172 µM -0.206239832234297 0.420934330161885 no 1965 0.418301787484539 2840 766306
SGTC_2677 mitomycin C 100 µM -0.20712666013784 0.420531902131325 no 1966 0.417955470880937 2790 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_927 2425-1185 123 µM -0.208136856733654 0.420073592597619 no 1967 0.41756105487979 2747 730375
SGTC_1118 chelidonine 707.474 nM -0.208340844494461 0.419981059844874 no 1968 0.417481420990134 2852 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1730 st033808 45.1 µM -0.208380602723027 0.419963025266318 no 1969 0.417465900343185 2763 1045166
SGTC_2936 9038235 15.59 µM -0.208724813318954 0.419806896239666 no 1970 0.417331534263413 2752 4749415
SGTC_2899 9053889 58.44 µM -0.210271331706075 0.41910557359847 no 1971 0.416727954541022 2829 6470052
SGTC_3317 9138495 8.753 µM -0.210702610554103 0.41891004090502 no 1972 0.416559668705266 2788 17020139
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.211270247499062 0.418652716875809 no 1973 0.416338198990925 2845 75037 A free radical scavenger.
SGTC_611 3453-1652 23.7 µM -0.211339457368749 0.418621344688567 no 1974 0.416311197824277 2876 1560575
SGTC_1321 1326-2144 215 µM -0.212060069362186 0.418294728791459 no 1975 0.416030085620008 2902 3513030
SGTC_560 2332-1943 155 µM -0.212307002155551 0.418182819960566 no 1976 0.415933766509582 2767 21177716
SGTC_2743 auranofin 4.32 µM -0.212598741969115 0.418050613325404 no 1977 0.415819976388597 2815 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1817 st052116 64.4 µM -0.212717494330739 0.417996801414668 no 1978 0.415773660268872 2929 4361398
SGTC_762 1165-0429 115 µM -0.212749578196753 0.417982263069202 no 1979 0.415761147032731 2935 5967793
SGTC_1050 3232-1156 69.3 µM -0.213238697183872 0.417760639678417 no 1980 0.415570393156063 2820 700529
SGTC_1317 1273-0028 910 nM -0.213573252984103 0.417609065035053 no 1981 0.415439929578361 2818 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1186 1319-0216 26 µM -0.213600068036023 0.417596916673679 no 1982 0.415429473168182 2954 4565136
SGTC_528 3492-0019 172 µM -0.214616306381817 0.417136575461755 no 1983 0.415033239756613 2844 2869262
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.214627727958198 0.417131402297761 no 1984 0.415028786950908 2847 140250 A respiratory chain inhibitor.
SGTC_1477 0139-0234 16 µM -0.218073068321117 0.415571566344485 no 1985 0.413686090395527 2781 620880
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.219129961402893 0.415093336177964 no 1986 0.413274406035393 2923 5024745
SGTC_1827 berberine 7.24 µM -0.219177465067405 0.415071844345355 no 1987 0.413255904492146 2794 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2092 5303694 80.6725 µM -0.220225962245637 0.414597543114957 no 1988 0.412847588991772 2810 1963699
SGTC_3301 9125354 19.7965 µM -0.220830045916336 0.414324334547652 no 1989 0.412612383899166 2777 41905162
SGTC_3237 9133362 49.47 µM -0.221321433685742 0.414102125454904 no 1990 0.412421081046879 2916 43845137
SGTC_2235 salicylic acid 500 µM -0.221979954007606 0.413804380942093 no 1991 0.412164744218344 2800 338 A COX inhibitor and kinase inhibitor.
SGTC_1185 1319-0113 81.3 µM -0.22418260018303 0.412808833659997 no 1992 0.411307610985989 2908 4672763
SGTC_934 2950-0684 338 µM -0.224489468651286 0.412670180252074 no 1993 0.411188230309607 3016 1121253
SGTC_187 1488-2104 32.728 µM -0.224907531903956 0.412481302868757 no 1994 0.411025604893565 2870 2852859
SGTC_1005 4092-0690 4.4 µM -0.226121703039418 0.411932865833437 no 1995 0.410553382561549 2863 1529343
SGTC_1649 st011737 51.3 µM -0.226654430728942 0.411692288737479 no 1996 0.410346231960648 2863 1761035
SGTC_1313 1220-0047 237 µM -0.227226456981817 0.411434001569505 no 1997 0.4101238280028 2850 3528706
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.22725121856122 0.411422821832717 no 1998 0.410114201346425 2985 551469
SGTC_714 4296-0578 26.1 µM -0.227638040871381 0.411248182720076 no 1999 0.409963821955784 2824 1589775
SGTC_1268 0828-0275 2.46 µM -0.228385290287907 0.410910870994738 no 2000 0.409673361975514 2910 745337
SGTC_1714 st033236 13.627 µM -0.229219777018174 0.410534257815087 no 2001 0.409349050959557 2968 2916566
SGTC_1017 4239-0030 168 µM -0.231028956543557 0.409718038577818 no 2002 0.408646153200428 2832 1149593
SGTC_1463 k081-0032 34.1 µM -0.233508712457274 0.408599921928687 no 2003 0.40768320248619 2886 977755
SGTC_2164 5685496 200 µM -0.233818027342671 0.408460504480826 no 2004 0.407563126833596 2842 759046
SGTC_2161 5662504 8.5105 µM -0.233954321505679 0.408399076310918 no 2005 0.407510220365165 2851 2859334
SGTC_2940 9060638 45.86 µM -0.235136959326531 0.407866152707631 no 2006 0.407051216676203 2939 4027022
SGTC_694 1315-0438 43.2 µM -0.235541284230417 0.407683993716663 no 2007 0.40689431992058 2860 6793154
SGTC_2273 7815444 169.05 µM -0.23556410113574 0.407673714695919 no 2008 0.406885466351585 3020 2824616
SGTC_1555 citronellol 128 µM -0.235621453953055 0.407647877520102 no 2009 0.406863212135991 2898 8842 A terpine precursor.
SGTC_1748 st037455 53.6035 µM -0.235935081308884 0.407506596971058 no 2010 0.406741522810626 3012 580690
SGTC_2114 5491910 81.25 µM -0.235961954100274 0.407494492072536 no 2011 0.406731096422447 2949 2849228
SGTC_576 1073-0113 22.7 µM -0.23709511857215 0.406984136574154 no 2012 0.406291499616157 2871 5439563
SGTC_1196 1588-0294 184 µM -0.237374443731131 0.406858358116501 no 2013 0.406183157079845 2879 6144269
SGTC_607 4491-0986 66.8 µM -0.237469577624332 0.406815522082701 no 2014 0.406146258902244 2962 698981 YDR232W HEM1
SGTC_1240 0356-0016 42.1 µM -0.237634883953288 0.406741092087518 no 2015 0.406082145961558 2876 4305613
SGTC_3198 9112019 49.47 µM -0.237775984091313 0.406677563714663 no 2016 0.406027423220396 2809 45595555
SGTC_781 4335-2806 94.4 µM -0.238285750224843 0.406448069085116 no 2017 0.405829736379189 3005 845254
SGTC_1642 st009582 77.7 µM -0.238913308099868 0.406165589228404 no 2018 0.405586402988416 2956 6739311
SGTC_319 1348-1596 45.5 µM -0.239929734962911 0.405708173157812 no 2019 0.405192364427669 3028 5380505
SGTC_1369 1866-0067 208 µM -0.242684916173282 0.404468925641281 no 2020 0.404124746669899 2955 3531355
SGTC_833 3852-0053 558 µM -0.242810824151593 0.404412316531807 no 2021 0.404075975004791 2997 3123681
SGTC_400 oxethazaine 37.5 µM -0.245895226512108 0.403026175354488 no 2022 0.40288166954902 2907 4621 A local anesthetic.
SGTC_1213 1315-0166 115 µM -0.246499548774929 0.402754732949921 no 2023 0.402647776845315 2952 768401
SGTC_2913 7966556 36.57 µM -0.246595179130369 0.402711783117319 no 2024 0.402610767925478 2938 2976516
SGTC_2564 betulinic acid 100 µM -0.248851695942344 0.401698670356644 no 2025 0.401737750525745 3130 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2189 6047310 154.431 µM -0.251001563893112 0.400734054012762 no 2026 0.400906450038167 2814 711535
SGTC_2033 5192550 145 µM -0.253350358499175 0.399680873676 no 2027 0.399998742315185 2888 182073
SGTC_312 4092-0653 6.84 µM -0.253580323802904 0.399577798193763 no 2028 0.399909899599277 2949 1148278
SGTC_2611 pyromycin 23.93 µM -0.256114276589794 0.398442490042574 no 2029 0.39893129921427 2894 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2149 5554786 194.827 µM -0.258928779455634 0.397182491901397 no 2030 0.397845096208238 2869 745063 YPR165W RHO1
SGTC_2246 7293507 91.5585 µM -0.259925532058208 0.396736521610458 no 2031 0.397460608122945 3033 887656
SGTC_2370 9071495 200 µM -0.259933523705998 0.396732946506325 no 2032 0.397457525820832 2954 21791103
SGTC_86 0417-1630 471.922 µM -0.259975117150291 0.396714339608425 no 2033 0.397441483730593 2904 3634867
SGTC_2054 5233173 129 µM -0.260255318772553 0.396588997067768 no 2034 0.397333417863255 3029 6889
SGTC_29 0299-0004 12.984 µM -0.260878909856561 0.396310084551462 no 2035 0.397092944655607 2881 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1424 4048-1941 275 µM -0.260962058586517 0.396272898767513 no 2036 0.397060883260928 2989 X1424
SGTC_722 3534-0461 190 µM -0.261021901468642 0.396246136411302 no 2037 0.397037808819895 2904 658262
SGTC_1670 st016595 4.04 µM -0.261635876177574 0.395971588829589 no 2038 0.396801091000872 2906 597879
SGTC_783 0848-0141 92.7 µM -0.262135236302366 0.395748330840974 no 2039 0.396608590845037 2839 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3272 9137413 49.47 µM -0.262531004329931 0.395571411940358 no 2040 0.396456042680632 2840 17614870
SGTC_358 0075-0058 9.45 µM -0.262903213065833 0.395405044306636 no 2041 0.3963125898698 2796 1069125
SGTC_672 1441-0018 53.7 µM -0.26562535345281 0.394188899561813 no 2042 0.395263878806083 2862 251141
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.265895410990685 0.394068304543442 no 2043 0.395159879709425 2853 803109
SGTC_872 0588-0139 234 µM -0.266073115303341 0.393988955679238 no 2044 0.395091449892087 2873 2047100
SGTC_2194 5927483 104.545 µM -0.267241230982494 0.393467476146489 no 2045 0.394641716210514 2866 760979
SGTC_137 0438-0332 85.389 µM -0.267578019142761 0.39331715992524 no 2046 0.394512076177003 2916 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2260 7964312 200 µM -0.267771956606322 0.393230608434524 no 2047 0.394437429032601 3047 231951
SGTC_221 trifluoperazine 10.304 µM -0.269231473588666 0.392579416640882 no 2048 0.393875780860883 2906 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1689 st020265 53.493 µM -0.26958383363627 0.392422249354232 no 2049 0.393740219452585 3015 5758320 YPR016C TIF6
SGTC_158 k038-0087 26.446 µM -0.269726224691122 0.392358741977184 no 2050 0.393685441831916 2859 X158
SGTC_1631 benzylvanillin 81.9 µM -0.270934760569958 0.391819842347744 no 2051 0.393220604736764 3022 75506
SGTC_798 1287-0182 476 µM -0.271100818273144 0.391745811556462 no 2052 0.393156746122839 3066 1649755
SGTC_3004 9076122 71.4286 µM -0.272066444377029 0.39131540000476 no 2053 0.392785465081493 3046 44782551
SGTC_335 4077-0256 27.6 µM -0.273652308180076 0.390608816861172 no 2054 0.392175915816492 2976 3121989
SGTC_2302 7771753 200 µM -0.275939065253865 0.389590586292672 no 2055 0.391297434272766 2967 2203047
SGTC_1845 st056753 3.01 µM -0.277526878609191 0.388884021399668 no 2056 0.390687784955953 2833 5375839
SGTC_768 0384-0033 77.3 µM -0.27768444040731 0.388813927593549 no 2057 0.39062730289759 2915 3965305 YMR134W ERG29
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.277931126574778 0.388704192701475 no 2058 0.39053261465541 2959 6857784
SGTC_1333 1482-0047 286 µM -0.278193620108932 0.388587435875508 no 2059 0.39043186602847 3032 3811116
SGTC_2792 7535235 81.82 µM -0.278833211087353 0.388302988693154 no 2060 0.390186413032719 2985 1281891
SGTC_3131 9127911 49.47 µM -0.279274773040019 0.388106646485603 no 2061 0.390016982293117 3136 45595681
SGTC_2808 7946468 45.46 µM -0.279852789275728 0.387849672585079 no 2062 0.389795224567956 2978 2970879
SGTC_2721 ifenprodil 61.44 µM -0.280193446265407 0.387698246621829 no 2063 0.389664547249741 3050 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3255 9139072 49.47 µM -0.280514488211413 0.387555555403465 no 2064 0.38954140575267 2973 17646060
SGTC_1155 4088-0394 48.2 µM -0.280568009321319 0.387531768734857 no 2065 0.389520877832392 2862 2326248
SGTC_1964 st076914 61 µM -0.282647732978337 0.386607793948477 no 2066 0.388723443004356 2872 24208661
SGTC_262 fenpropimorph 62.5 µM -0.284000619760834 0.38600708110365 no 2067 0.388204952845221 2881 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3225 9130819 49.47 µM -0.284728830089601 0.385683851984038 no 2068 0.3879259506311 3034 4547121
SGTC_830 4076-0286 57.8 µM -0.284729499759545 0.385683554775603 no 2069 0.387925694084304 2908 6866659
SGTC_1026 k007-1105 30.6 µM -0.287493348643012 0.384457495526461 no 2070 0.386867297049411 2913 7066794
SGTC_2636 apigenin dimethyl ether 100 µM -0.28801844054211 0.384224691924642 no 2071 0.38666631149799 3054 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1131 3454-3128 32.3 µM -0.289198293077465 0.383701747524171 no 2072 0.386214818999292 3067 710982
SGTC_2204 7233102 200 µM -0.291709922090094 0.382589227905362 no 2073 0.385254211148071 2933 2172480
SGTC_3079 9117512 49.47 µM -0.293913827135226 0.381613810981899 no 2074 0.384411876001646 2924 7185044
SGTC_2607 solasodine 47.35 µM -0.29770004976944 0.379939839943205 no 2075 0.382966052719155 2939 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2271 7849410 118.62 µM -0.29791613461644 0.379844371636693 no 2076 0.382883586579896 3053 972430
SGTC_3015 9080845 49.47 µM -0.298381288909992 0.379638886973273 no 2077 0.382706084150411 3064 5296973
SGTC_1282 0886-0010 32.4 µM -0.298617047501364 0.379534752194077 no 2078 0.382616128304267 3098 2836211 YNL267W PIK1
SGTC_3065 9113888 49.47 µM -0.299992255292629 0.378927496050111 no 2079 0.382091531551504 3130 16648368
SGTC_3333 9141820 12.094 µM -0.300076515594964 0.378890298580044 no 2080 0.382059396030394 2957 1939433
SGTC_2772 vinpocetine 57.06 µM -0.302258048295749 0.377927632687372 no 2081 0.381227678061945 3142 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2726 cimetidine 79.27 µM -0.302410347618382 0.377860454323324 no 2082 0.38116963377457 2932 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1019 4262-0212 3.4 µM -0.302499512573408 0.377821125883463 no 2083 0.381135652485365 3011 4677213
SGTC_1384 3089-0840 101 µM -0.303145170974011 0.377536379861676 no 2084 0.380889615631304 3071 1069836
SGTC_1419 3993-2473 62.6 µM -0.304407045154784 0.376980064757647 no 2085 0.380408900532468 2972 704026
SGTC_414 piperonyl butoxide 100 µM -0.304417686056236 0.376975374649383 no 2086 0.380404847630233 2945 5794 A potent inhibitor of cytochrome P450.
SGTC_1362 1611-0397 101 µM -0.305633142944677 0.376439766685148 no 2087 0.379941991401772 2953 27816
SGTC_2444 5485484 36.41 µM -0.306305758983222 0.376143471230849 no 2088 0.379685927394442 3076 6790631
SGTC_44 0929-0055 61.211 µM -0.306589855726357 0.376018345113386 no 2089 0.379577787991863 2921 1379590
SGTC_3192 9110362 49.47 µM -0.306656776016419 0.375988872978982 no 2090 0.379552316630218 2921 16649480
SGTC_1665 st014639 11.4 µM -0.307732384756761 0.375515267192031 no 2091 0.379142987636463 2980 981133 YIL048W NEO1
SGTC_1802 st050112 57.9 µM -0.307986098672214 0.375403580664505 no 2092 0.379046455099401 2927 4662563
SGTC_2272 7805186 180 µM -0.308163039854777 0.375325696177073 no 2093 0.378979137354474 3080 2956062 YPR165W RHO1
SGTC_2258 7960471 200 µM -0.308591534545006 0.37513710603431 no 2094 0.378816130617567 3021 2974708
SGTC_265 mycophenolic acid 32.932 µM -0.308839363421974 0.375028044595624 no 2095 0.378721862093765 3199 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2095 5432005 200 µM -0.309752069214752 0.374626478641095 no 2096 0.378374751618534 2949 783734
SGTC_77 0828-0286 12.516 µM -0.309973203615981 0.374529205902889 no 2097 0.378290666911714 2964 745345
SGTC_1804 st050076 49.1 µM -0.310438637263482 0.374324496755075 no 2098 0.378113708074329 3078 3895976
SGTC_395 anisomycin 6.25 µM -0.310696673553715 0.374211021318347 no 2099 0.378015613155947 3004 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2855 9016525 58.44 µM -0.31197675395233 0.373648247526635 no 2100 0.377529094962839 2920 43811474
SGTC_1191 1487-1166 10.6 µM -0.312138544000475 0.373577137391259 no 2101 0.377467617480111 3064 3955771
SGTC_2472 5377652 49.4 µM -0.31263962863532 0.373356927453572 no 2102 0.377277233495312 3003 1610903
SGTC_1680 diphenhydramine 100 µM -0.313556299368177 0.372954188393374 no 2103 0.376929027374536 2998 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.314200380651248 0.372671294440525 no 2104 0.376684426798286 2943 6708514
SGTC_2570 licareol 100 µM -0.315911986211028 0.371919855598706 no 2105 0.376034656904719 3033 443158
SGTC_2540 epiandrosterone 100 µM -0.316018829102317 0.371872964962645 no 2106 0.375994108199617 2986 441302 A steroid.
SGTC_364 0083-0097 67.7 µM -0.316118295241155 0.371829313504365 no 2107 0.375956360328815 3091 5207356
SGTC_1801 st050089 28.441 µM -0.318311163281752 0.37086737647179 no 2108 0.375124458642822 2959 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.318712502158078 0.37069140981501 no 2109 0.374972266668102 3092 521171
SGTC_351 caspofungin 25 nM -0.319966333306867 0.370141843093712 no 2110 0.374496926049828 2992 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2797 7859098 81.82 µM -0.323440763715988 0.368620353279315 no 2111 0.373180731068752 2984 972681
SGTC_1242 0402-0103 60.1 µM -0.324679357405564 0.36807845617154 no 2112 0.372711879683775 2945 432868
SGTC_2649 anisomycin 9.56 µM -0.324755983264573 0.368044940200999 no 2113 0.372682880279468 3034 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3044 9093193 49.47 µM -0.325831265700914 0.367574720245106 no 2114 0.372276010944259 3086 25236277
SGTC_2592 piperlongumine 83.33 µM -0.326723189183692 0.36718483352308 no 2115 0.371938629770737 3061 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3256 9138902 49.47 µM -0.328917135577643 0.366226376546073 no 2116 0.371109160995645 2993 17228773
SGTC_1290 0986-0249 10.2 µM -0.330159009341683 0.365684215399512 no 2117 0.370639908798839 3041 53329
SGTC_638 3970-0837 4.09 µM -0.331066122887261 0.365288368951653 no 2118 0.370297270032731 3003 4118451 YLR208W SEC13
SGTC_513 4245-1575 41.7 µM -0.331610355491054 0.365050945417117 no 2119 0.370091749554978 3070 719745
SGTC_2720 fluspirilene 36.88 µM -0.332521781749578 0.364653448146679 no 2120 0.369747647533094 3075 3396 An atypical antipsychotic.
SGTC_1066 ketoconazole 628 nM -0.333113154088151 0.364395612700528 no 2121 0.369524435184572 3144 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2734 clemastine 41.6 µM -0.333963702889237 0.364024885175276 no 2122 0.369203474291316 3018 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2165 5727197 32.143 µM -0.33443944956279 0.363817577591184 no 2123 0.369023987498824 3357 1361712
SGTC_870 0573-2213 57.6 µM -0.334613276967717 0.363741841883445 no 2124 0.368958414080652 2981 3916321
SGTC_2295 7971645 200 µM -0.334984172635027 0.363580262346768 no 2125 0.368818512780997 3033 2978226 YKL099C UTP11
SGTC_1962 st076595 64.5 µM -0.335837927138937 0.363208419116666 no 2126 0.368496543918689 2994 279619
SGTC_1087 pterostilbene 9.05 µM -0.338510403242585 0.36204528662099 no 2127 0.367489294350378 3135 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2712 st079126 47.7 µM -0.339131663283042 0.36177507972053 no 2128 0.367255273235631 2985 3152970
SGTC_2783 7738165 71.43 µM -0.342070022974974 0.360498023799024 no 2129 0.366149098168247 3070 17201110
SGTC_2290 7904846 200 µM -0.343713624641961 0.359784366437119 no 2130 0.365530831901326 3076 2962154
SGTC_3167 9103034 49.47 µM -0.344100021079844 0.359616662649025 no 2131 0.36538553352535 3042 5127859
SGTC_2344 7990960 76.95 µM -0.345386895133768 0.359058328634324 no 2132 0.364901763943574 3031 140813
SGTC_2085 5307070 144.047 µM -0.345628268859517 0.358953637676256 no 2133 0.364811049174186 2978 2840351
SGTC_3295 9122362 53.5725 µM -0.345753596312421 0.358899283612964 no 2134 0.364763950714799 3103 4730473
SGTC_260 nsc-65238 3.989 µM -0.345855596038761 0.358855048809 no 2135 0.364725620396353 3145 3246252
SGTC_202 3594-0513 34.79 µM -0.346484531421598 0.358582336648099 no 2136 0.364489303634286 3024 708429
SGTC_274 sirtinol 40.1 µM -0.346526003806747 0.358564356373092 no 2137 0.364473722570701 3048 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2800 7887935 81.82 µM -0.347884702226206 0.357975468807276 no 2138 0.363963387201372 3171 2961002
SGTC_1048 3161-0300 24.5 µM -0.350376010280489 0.356896563525875 no 2139 0.363028263883457 3034 2165101
SGTC_1619 st003326 88.7 µM -0.350385267992338 0.356892556436528 no 2140 0.363024790479473 3163 2849032
SGTC_2162 5663267 200 µM -0.350853939132885 0.356689718405476 no 2141 0.362848964327287 3176 6456493
SGTC_2026 5148700 152 µM -0.351067527302956 0.356597292176208 no 2142 0.362768844410757 2998 79838
SGTC_2355 9061122 103.12 µM -0.35159376274005 0.35636960971136 no 2143 0.362571471762531 3129 5302957
SGTC_121 0557-0495 61.343 µM -0.352334268530532 0.356049307156531 no 2144 0.362293795596032 3040 3104427
SGTC_1500 4488-1866 171 µM -0.353159018540149 0.355692684687892 no 2145 0.361984614657694 3152 2900003
SGTC_3034 9090421 49.47 µM -0.353647171798727 0.35548166634958 no 2146 0.361801658967163 3070 17173761
SGTC_811 0416-0114 265 µM -0.3539466687379 0.355352222070953 no 2147 0.361689425690693 3117 6612453
SGTC_2485 5633444 17.78 µM -0.355265544150729 0.354782395329106 no 2148 0.361195332892299 3104 5724239
SGTC_949 1165-0505 146 µM -0.355385238584953 0.354730696802919 no 2149 0.361150502983976 3034 6244267
SGTC_572 0960-0087 17.7 µM -0.355386624867043 0.354730098054399 no 2150 0.361149983782206 3061 6796365
SGTC_3113 9123498 49.47 µM -0.355915242881544 0.354501809040252 no 2151 0.360952020069552 3094 8897275
SGTC_2871 9038510 12.99 µM -0.357084694715561 0.3539969552714 no 2152 0.360514201016888 3233 4945164
SGTC_1731 st035964 63 µM -0.357746290835325 0.353711457001316 no 2153 0.360266593769133 3043 6739575
SGTC_2457 5731572 11.68 µM -0.357862720877888 0.353661222505818 no 2154 0.36022302502421 3157 2865357
SGTC_1545 lovastatin 49.4 µM -0.358879965497539 0.353222434207643 no 2155 0.359842443915849 3120 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_403 arphamenine a 50 µM -0.359162828865543 0.353100455776496 no 2156 0.359736641086176 3033 5487158 An arginine aminopeptidase inhibitor.
SGTC_1515 3460-0031 42.1 µM -0.360049255619227 0.352718302090612 no 2157 0.359405149746899 3075 2876596
SGTC_565 1418-0001 44.5 µM -0.360296772361075 0.35261161992146 no 2158 0.359312606377952 3203 2862145
SGTC_127 0180-0333 59.125 µM -0.360849223242966 0.352373549932557 no 2159 0.359106081776587 3071 771601
SGTC_1347 1493-0251 600 nM -0.360888363761087 0.352356685136561 no 2160 0.359091451303911 3164 3986378
SGTC_1390 3413-2614 145 µM -0.362155771641126 0.351810743766563 no 2161 0.358617814230625 3104 3421432
SGTC_2181 6316240 54.2555 µM -0.36253866244484 0.351645871932879 no 2162 0.358474768617918 3119 12779990
SGTC_1952 st077036 64.1 µM -0.362805521922008 0.35153097939863 no 2163 0.358375083324464 3023 2937007
SGTC_892 0929-0076 29 µM -0.362975361344538 0.351457864524051 no 2164 0.358311644874321 3053 5751038
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.363327941051474 0.351306098578837 no 2165 0.358179961729746 3165 61125 An anti-inflammatory.
SGTC_2218 6965428 192.983 µM -0.363438380374938 0.351258565469916 no 2166 0.358138717794946 3121 675684
SGTC_248 streptozotocin 5.23457 mM -0.363573846256365 0.351200264102176 no 2167 0.35808812986901 3132 5300 DNA alkylating agent.
SGTC_38 0929-0051 58.268 µM -0.363986550621396 0.351022667322617 no 2168 0.357934026291477 3166 1379719
SGTC_730 1436-0052 41.2 µM -0.365742481998845 0.350267411240328 no 2169 0.357278621535837 3050 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1834 st055981 52.8 µM -0.365886976297543 0.350205288084101 no 2170 0.357224707475186 3206 471719 YDL150W RPC53
SGTC_2414 st077232 92.9 µM -0.366481257580643 0.349949827916467 no 2171 0.357002997790779 2989 729801
SGTC_2981 9013952 38.96 µM -0.36668304888774 0.349863100521758 no 2172 0.356927726088987 3091 2996344
SGTC_6 0844-0013 19.835 µM -0.367009583659576 0.349722776530803 no 2173 0.356805934682943 3139 1584900
SGTC_966 1300-0360 30.2 µM -0.367739123963386 0.349409340439675 no 2174 0.35653388244349 3050 70588
SGTC_906 1165-0455 526 µM -0.367865327201218 0.349355129513765 no 2175 0.356486827504498 3048 3252859
SGTC_2963 9082507 9 µM -0.369779291308647 0.348533358559715 no 2176 0.35577347320823 3208 16459611
SGTC_1690 st023502 41.2 µM -0.370172588779465 0.348364581992332 no 2177 0.355626949592956 3153 24207482
SGTC_3172 9105863 49.47 µM -0.37061538012487 0.348174601939553 no 2178 0.355462012480705 3100 2348785
SGTC_574 1315-0397 40 µM -0.371022642580692 0.347999899220203 no 2179 0.355310333559912 3053 6794277
SGTC_1331 1472-0049 76.2 µM -0.371349815832634 0.347859575602057 no 2180 0.355188499286376 3008 24051409
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.371816177827834 0.347659590373552 no 2181 0.355014858860422 3115 5379071
SGTC_1217 1183-1422 255 µM -0.371818948283542 0.347658402474052 no 2182 0.355013827427379 3201 2849664
SGTC_3209 9113616 49.47 µM -0.372762994362898 0.347253707179051 no 2183 0.354662423578396 3267 16649353
SGTC_374 0880-0231 82.3 µM -0.374870667819687 0.34635081490811 no 2184 0.353878327323452 3118 6833587
SGTC_2515 chrysin 20.77 µM -0.376916065699142 0.345475434430723 no 2185 0.353117990885264 3155 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1662 st014054 52 µM -0.377111965489615 0.345391637352173 no 2186 0.353045199694868 3097 2838777
SGTC_200 k038-0079 37.545 µM -0.378583600960538 0.344762380719037 no 2187 0.352498550898316 3062 3436683
SGTC_682 0kpi-0099 17 µM -0.379909756499429 0.344195697431357 no 2188 0.352006202375423 3159 1714895 YML126C ERG13
SGTC_525 k781-2675 26.7 µM -0.380057777229475 0.344132467942714 no 2189 0.351951263568397 3160 3651118 YDL195W SEC31
SGTC_1412 3909-8563 178 µM -0.380139651494972 0.344097495875568 no 2190 0.351920876757168 3193 23767530
SGTC_1439 4092-1168 46 µM -0.381760735947371 0.343405334961489 no 2191 0.351319422510297 3145 2886240
SGTC_2152 5568786 200 µM -0.382352882906959 0.343152634353653 no 2192 0.351099817044716 3126 5399883
SGTC_456 gingerol 170 µM -0.38254183851625 0.343072011696585 no 2193 0.351029750839094 3262 442793 A herb.
SGTC_1309 pyrazolanthrone 13.4 µM -0.382787572079868 0.342967173985201 no 2194 0.350938638503656 3191 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_508 roscovitine 141 µM -0.383474019600761 0.342674377831523 no 2195 0.350684165024091 3068 160355 A CDKinase inhibitor.
SGTC_2508 celastrol 40.54 µM -0.383910694758222 0.342488168316959 no 2196 0.350522319695164 3115 122724 Celastrol is a natural product and antioxidant.
SGTC_3203 9113543 49.47 µM -0.385015546355303 0.342017202216748 no 2197 0.350112948717182 3218 17018012
SGTC_1153 4055-0057 267 µM -0.385963726541355 0.341613216447332 no 2198 0.349761766628942 3084 882706
SGTC_1279 0874-0590 65.2 µM -0.385979887390489 0.341606332456382 no 2199 0.349755782169919 3131 3523074
SGTC_2147 5545932 89.7195 µM -0.386602967624932 0.341340960932439 no 2200 0.349525080312294 3118 797404
SGTC_3022 9087993 49.47 µM -0.38686307723242 0.341230202758694 no 2201 0.349428788493621 3169 17173644
SGTC_1039 k821-0043 94 µM -0.387090024243534 0.341133576836787 no 2202 0.349344781286134 3217 15992768
SGTC_418 lividomycin a 100 µM -0.387121827893731 0.341120036811858 no 2203 0.349333009366105 3223 72394 An antibiotic.
SGTC_2728 chlorpromazine 9.18 µM -0.387350618137161 0.34102263812381 no 2204 0.3492483283763 3072 2726 A thorazine and dopamine antagonist.
SGTC_2455 5377712 9.75 µM -0.388068044962118 0.340717289832763 no 2205 0.348982839447069 3149 2243908
SGTC_2250 alverine citrate 130 µM -0.391119212712331 0.339419831818477 no 2206 0.347854559924333 3111 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1944 st076371 56.9 µM -0.391490042492307 0.33926227193434 no 2207 0.34771752374833 3063 24208455
SGTC_578 3460-0051 92 µM -0.391495381304794 0.339260003759955 no 2208 0.347715550992541 3227 2876744
SGTC_2359 9039622 200 µM -0.391846538568595 0.339110828712601 no 2209 0.347585803193327 3039 6463596
SGTC_236 1509-0011 5.31 µM -0.393346454458941 0.338473933901976 no 2210 0.347031805958537 3242 3107280
SGTC_2732 terfenadine 20 µM -0.393646726044442 0.338346487890745 no 2211 0.346920939208454 3111 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1516 st013856 110 µM -0.394268412716873 0.338082680677641 no 2212 0.346691440731366 3181 5281404 A mutagen and neurotoxin.
SGTC_1013 4112-3890 241 µM -0.394635446287657 0.337926970552947 no 2213 0.346555975011673 3036 705171
SGTC_1276 0871-0068 94.2 µM -0.396317939981233 0.337213545571727 no 2214 0.345935247141783 3175 3414906
SGTC_2767 sibutramine 71.45 µM -0.396521713875663 0.337127179333958 no 2215 0.345860096237869 3306 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_835 0312-0010 67.2 µM -0.398724661094906 0.336194044950602 no 2216 0.345048047317686 3076 1626196
SGTC_2386 9075165 157.42 µM -0.398884297937746 0.336126464368953 no 2217 0.344989229756926 3157 16452277
SGTC_1245 0418-0076 17.2 µM -0.400195638625062 0.335571522670216 no 2218 0.344506213345231 3259 6790114
SGTC_275 trichlorophene 5.69 µM -0.400909936210621 0.335269392290712 no 2219 0.344243217076906 3195 62616
SGTC_2429 5902844 64.44 µM -0.401261165826804 0.335120869822909 no 2220 0.344113925926692 3219 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_79 0052-0007 94.094 µM -0.401454097570356 0.335039296841468 no 2221 0.344042913565923 3261 2801472
SGTC_671 0560-0003 407 µM -0.402150806569238 0.334744787879028 no 2222 0.343786521786505 3108 3238678
SGTC_3182 9108849 49.47 µM -0.403023345466711 0.334376096420016 no 2223 0.34346552519714 3215 17133045
SGTC_2565 isoliquiritigenin 100 µM -0.404529394383367 0.333740091071083 no 2224 0.342911733510992 3215 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.404718975344159 0.333660064712688 no 2225 0.342842046268458 3253 5377381
SGTC_1879 gemcitabine 100 µM -0.404962902233439 0.33355710885617 no 2226 0.342752390107668 3122 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2715 st079500 56.4 µM -0.406289222254495 0.332997519613007 no 2227 0.342265051760849 3080 28246688
SGTC_2387 9077560 195.08 µM -0.407276284297372 0.332581308254885 no 2228 0.341902539525558 3124 5303272
SGTC_644 1498-1197 63.3 µM -0.407358248930082 0.332546755754911 no 2229 0.341872443424376 3215 6741615
SGTC_1310 1188-0297 994 nM -0.408173510600164 0.332203156614578 no 2230 0.341573147120172 3138 1588352
SGTC_1607 st000305 50.6 µM -0.40833829798872 0.332133722654735 no 2231 0.341512662984343 3248 5457690
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.408778270838002 0.331948366214046 no 2232 0.341351193763251 3160 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1015 4130-4525 82 µM -0.409104701339781 0.331810870669727 no 2233 0.341231413136255 3131 1363237
SGTC_855 0428-0020 25 µM -0.410171043013335 0.331361875634824 no 2234 0.340840240531542 3143 6812414
SGTC_2172 5754775 163.918 µM -0.411066025565289 0.330985220237976 no 2235 0.340512060651849 3116 2263357
SGTC_728 3030-5151 22.5 µM -0.411386079162332 0.330850566459265 no 2236 0.340394729944902 3120 3125388
SGTC_3239 9133757 49.47 µM -0.41227143640814 0.330478190697193 no 2237 0.340070241084213 3133 17036923
SGTC_963 1269-2853 151 µM -0.412398299590996 0.330424846564004 no 2238 0.340023754644547 3116 3668223
SGTC_3348 9149464 3.537 µM -0.414349839583088 0.329604686950166 no 2239 0.339308959240234 3167 1951442
SGTC_3151 9099821 49.47 µM -0.414409965382392 0.329579431298001 no 2240 0.339286945977192 3224 17174189
SGTC_1364 1653-0028 37.6 µM -0.415760613132485 0.32901230099409 no 2241 0.338792591375711 3183 5718652
SGTC_2011 4012611 177 µM -0.416522375766485 0.328692614038468 no 2242 0.338513898721077 3110 2049887
SGTC_673 1082-0474 110 µM -0.416806590222802 0.328573370581399 no 2243 0.338409940832523 3161 3098046
SGTC_318 1488-0629 67.2 µM -0.416970556095815 0.328504585898804 no 2244 0.338349972193691 3226 3662576
SGTC_972 1319-0219 195 µM -0.417033705697056 0.328478095806379 no 2245 0.338326877044301 3199 23903702
SGTC_2383 9036125 200 µM -0.41754895679881 0.328261989701646 no 2246 0.3381384615146 3119 79580
SGTC_907 3448-6986 75.5 µM -0.418290871839772 0.327950917378276 no 2247 0.337867231382344 3316 590582
SGTC_2368 9071271 200 µM -0.418881669290207 0.327703291407808 no 2248 0.337651307174381 3164 27209959
SGTC_2040 5100729 123 µM -0.418922542429255 0.32768616270124 no 2249 0.337636370865596 3123 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_640 3381-0960 37.1 µM -0.41903026523572 0.327641021041446 no 2250 0.337597006846669 3219 1745025
SGTC_204 PMA1.184 62.41 µM -0.421004617436437 0.326814107877825 no 2251 0.336875855064431 3171 2252213 YGL008C PMA1
SGTC_2653 dihydrofissinolide 100 µM -0.421812659117487 0.326475922579057 no 2252 0.336580882465554 3240 6857746
SGTC_296 1222-0039 74.9 µM -0.423580970194156 0.325736338639259 no 2253 0.335935718020877 3183 5984176
SGTC_1254 0550-0035 264 µM -0.42414860465443 0.325499074598725 no 2254 0.335728720165551 3261 15121435
SGTC_3026 9090633 49.47 µM -0.424805717898335 0.325224497845102 no 2255 0.335489154539847 3138 25236842
SGTC_3085 9117376 49.47 µM -0.425247184538757 0.32504008294104 no 2256 0.335328245348722 3251 16480349
SGTC_1936 st074407 74.3 µM -0.425952624808828 0.324745486675756 no 2257 0.335071183705035 3137 809813
SGTC_2796 7949634 45.45 µM -0.426373392790565 0.324569823500385 no 2258 0.334917893088341 3123 2971588
SGTC_2610 ononetin 44.17 µM -0.427185443458179 0.324230917083459 no 2259 0.334622131452612 3213 259632
SGTC_2674 ligustilide 100 µM -0.429058209511259 0.323449880289325 no 2260 0.33394043192323 3237 5319022 A signalling regulator.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.430524528696107 0.322838894401093 no 2261 0.333407063896787 3083 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2862 9027634 71.43 µM -0.430845861388326 0.322705065272296 no 2262 0.333290225283911 3123 5012562
SGTC_1883 5-benzylidenerhodanine 20 µM -0.431967313488501 0.322238181191196 no 2263 0.332882584952544 3264 1273210
SGTC_2353 9059630 146.67 µM -0.432494529435752 0.322018786931812 no 2264 0.332691013682956 3249 4779114
SGTC_59 0330-0160 1.33 µM -0.433314699452331 0.321677606832014 no 2265 0.332393080305039 3262 4293482
SGTC_2481 5478948 45.16 µM -0.433457669054139 0.321618148708621 no 2266 0.332341156274113 3293 77792
SGTC_3115 9123671 49.47 µM -0.43375603443784 0.321494079386814 no 2267 0.332232805608831 3293 3286988
SGTC_1028 k015-0029 4.8 µM -0.434363885883584 0.321241378042274 no 2268 0.332012109220339 3141 4588309
SGTC_1550 gossypolone 36.6 µM -0.434490334549834 0.321188820084067 no 2269 0.331966206038554 3172 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3078 9116413 49.47 µM -0.435145907214326 0.320916390968579 no 2270 0.33172826159791 3108 17177322
SGTC_51 1013-0126 23.419 µM -0.435464935686176 0.320783850675862 no 2271 0.331612492646038 3416 1627850
SGTC_3212 9128307 49.47 µM -0.435724405069894 0.320676071031569 no 2272 0.331518348335839 3045 27243542
SGTC_3253 9135987 49.47 µM -0.436211473161518 0.320473791163406 no 2273 0.331341652225081 3263 4182430
SGTC_2680 butyl paraben 22.24 µM -0.436467764733421 0.320367374420406 no 2274 0.331248691129164 3247 7184 An antifungal and steroid mimetic.
SGTC_1677 st019204 53.9 µM -0.436600014486452 0.320312467786308 no 2275 0.331200726072908 3247 3945625
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.438047749310159 0.319711663641233 no 2276 0.330675835015845 3293 5282362
SGTC_738 1315-0003 72.4 µM -0.4391179206481 0.319267850616561 no 2277 0.330288047317662 3308 6251474
SGTC_1341 1486-1360 280 µM -0.440181343656847 0.318827092593072 no 2278 0.329902885417014 3151 3976547
SGTC_1859 st055998 20 µM -0.440297166237375 0.318779102945687 no 2279 0.329860946436893 3337 676301
SGTC_863 0466-0191 129 µM -0.441041286124962 0.31847085861657 no 2280 0.329591554071081 3286 765160 YPR165W RHO1
SGTC_3349 9149703 23.001 µM -0.442203291209584 0.317989760743251 no 2281 0.329171052333435 3213 4910494
SGTC_3120 9124077 49.47 µM -0.44650929218142 0.316209655146699 no 2282 0.327614700966603 3237 18774327 YGL155W CDC43
SGTC_2215 7188065 200 µM -0.44668452337859 0.31613730412982 no 2283 0.327551428941154 3307 940217
SGTC_982 1491-0518 27.5 µM -0.448193414917629 0.315514591103118 no 2284 0.32700680738804 3181 3091256
SGTC_1182 1222-0449 220 µM -0.449204301967451 0.31509769511053 no 2285 0.326642142217516 3254 658318
SGTC_849 0386-0493 241 µM -0.450335254981557 0.314631562188216 no 2286 0.326234360946969 3180 726119
SGTC_531 3788-1495 174 µM -0.451808012174252 0.314024994122491 no 2287 0.325703648602792 3128 2896655
SGTC_405 ebelactone b 50 µM -0.453026486703901 0.313523534051572 no 2288 0.325264834571846 3230 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_923 1900-2434 73.3 µM -0.454395161303045 0.312960670263875 no 2289 0.324772217198583 3201 5910570
SGTC_171 k064-0041 9.68 µM -0.454730881580504 0.312822672683546 no 2290 0.324651430520517 3197 53325
SGTC_480 am 92016 50 µM -0.45507947781958 0.312679410202789 no 2291 0.324526030794177 3249 2129 K+ channel blocker.
SGTC_478 N-arachidonylglycine 10 µM -0.455473484715259 0.312517519383534 no 2292 0.32438431954436 3251 5283389
SGTC_1562 morin hydrate 59.1 µM -0.45566205191427 0.312440053083573 no 2293 0.324316507155375 3350 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_21 0849-0113 22.993 µM -0.455942213912022 0.31232497353934 no 2294 0.324215766275813 3232 1560156
SGTC_1792 st045773 43.6 µM -0.458023774302358 0.311470524128038 no 2295 0.323467680477806 3174 2919270
SGTC_55 0767-0285 6.563 µM -0.458532290829502 0.311261939702985 no 2296 0.323285034487989 3303 3116166
SGTC_1436 4092-1007 8.32 µM -0.458925983843771 0.311100495444294 no 2297 0.323143659379054 3208 2881121
SGTC_177 1327-0068 8.361 µM -0.460952886309057 0.31026988605355 no 2298 0.322416203596369 3309 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1032 k061-1018 98.7 µM -0.463953268857088 0.309042127449676 no 2299 0.32134061338582 3384 4005393
SGTC_1669 st015249 58.4 µM -0.464864914465263 0.308669502726458 no 2300 0.321014098720503 3328 722793
SGTC_596 1155-0152 116 µM -0.465013961498199 0.308608600174592 no 2301 0.32096072924093 3250 280313
SGTC_932 2857-0803 154 µM -0.467274858660835 0.307685414657409 no 2302 0.320151620774574 3408 674898
SGTC_2556 citropten 84.59 µM -0.467521104462373 0.307584939185577 no 2303 0.32006354819358 3232 2775 A potential DNA crosslinker.
SGTC_1151 3909-8316 15.3 µM -0.467778296507328 0.30748001273617 no 2304 0.319971571390398 3325 800431
SGTC_1930 st074634 34.3 µM -0.467925852585266 0.307419821501739 no 2305 0.319918807504516 3191 684253 YOR116C RPO31
SGTC_1250 0485-0349 40.2 µM -0.469002589503371 0.306980754889882 no 2306 0.319533892539299 3211 6842794 YDL195W SEC31
SGTC_1900 st060200 72.8 µM -0.469096125840017 0.306942626144266 no 2307 0.319500464073563 3207 688945
SGTC_2499 avocadenofuran 51.48 µM -0.469852138162185 0.306634525238793 no 2308 0.319230330610872 3186 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_389 tpck 16.7 µM -0.470659478189929 0.306305657348074 no 2309 0.318941962994908 3278 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2145 5634607 200 µM -0.471792677770233 0.305844314562752 no 2310 0.318537388933085 3210 308662
SGTC_1402 3909-7673 35.9 µM -0.472412544201733 0.30559208774162 no 2311 0.318316176154253 3280 5328014
SGTC_653 0203-0016 55.2 µM -0.472887981643746 0.305398692302638 no 2312 0.318146549879245 3268 295302
SGTC_317 4495-0002 170 µM -0.473722251572189 0.305059464507949 no 2313 0.317848991754621 3265 15991618
SGTC_3245 9134821 49.47 µM -0.479808368039857 0.302589830539213 no 2314 0.315681831044711 3238 17014901
SGTC_1820 st053765 18.6 µM -0.480178070371762 0.302440101208096 no 2315 0.31555038941262 3307 3690829
SGTC_1985 st071382 65.5 µM -0.480486397361833 0.30231525428548 no 2316 0.315440786624615 3308 6123237
SGTC_1955 wogonin 32.4 µM -0.481076484051458 0.30207638248671 no 2317 0.315231070355763 3439 5281703 A flavanone.
SGTC_1643 st009866 20.2 µM -0.484164386109371 0.300827759719124 no 2318 0.314134604844921 3322 3156273 YOR207C RET1
SGTC_2673 kobusone 100 µM -0.484223485358194 0.300803885092258 no 2319 0.314113635579861 3323 6710676 An epoxy ketone and protein crosslinker.
SGTC_2236 dapsone 200 µM -0.484513783785155 0.300686624160671 no 2320 0.314010642229209 3338 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2924 9010168 62.78 µM -0.486859999349957 0.299739669922994 no 2321 0.313178773771743 3323 2993929
SGTC_1527 coumarin 137 µM -0.487556720190079 0.29945872728201 no 2322 0.312931928854836 3385 323 A hepatotoxic, DNA x-linker.
SGTC_1812 st052057 4.327 µM -0.487638312589596 0.299425834132868 no 2323 0.312903026533584 3257 3645418
SGTC_3122 9126309 49.47 µM -0.487851078969965 0.299340067229364 no 2324 0.3128276641108 3360 17591206
SGTC_2411 st077133 39.94 µM -0.488187164580314 0.299204612601293 no 2325 0.312708637623366 3483 1403142 YNL221C POP1
SGTC_1459 k035-0031 35.7 µM -0.488707979600941 0.298994760322828 no 2326 0.312524226823912 3209 3877128 YMR208W ERG12
SGTC_582 0987-0078 156 µM -0.490124048885008 0.298424520982502 no 2327 0.312023060721318 3405 1625765
SGTC_879 0831-1030 162 µM -0.491777714386032 0.297759230791404 no 2328 0.311438246272755 3334 1549252
SGTC_2934 9036370 36.88 µM -0.492047261325573 0.297650852866048 no 2329 0.311342966735864 3303 6462800
SGTC_3001 9076041 71.4286 µM -0.492151782293955 0.297608832503997 no 2330 0.311306024030736 3289 16004211
SGTC_1747 st037496 66.6 µM -0.492180651268912 0.297597226843236 no 2331 0.311295820690285 3247 723305
SGTC_445 e6 berbamine 66 µM -0.493727275736429 0.296975768205008 no 2332 0.310749399735296 3349 6610268 A calcium/calmodulin antagonist.
SGTC_1975 st070967 30.8 µM -0.49401470167143 0.296860341279288 no 2333 0.310647898355025 3404 261391
SGTC_1114 scopoletin 1.73284 µM -0.494857598688476 0.296521962052407 no 2334 0.310350321454958 3383 5280460 A coumarin with genotoxic properties.
SGTC_2216 7189485 200 µM -0.496413971131421 0.295897624518728 no 2335 0.309801184973711 3350 731273
SGTC_1646 st011709 75.6 µM -0.497492903544756 0.295465166285558 no 2336 0.309420752993961 3365 5757843
SGTC_1977 st070720 65.3 µM -0.497633134236777 0.295408980302291 no 2337 0.309371322582375 3372 682188
SGTC_2865 9030313 51.95 µM -0.498607626909673 0.295018667876518 no 2338 0.30902791553165 3220 42562754
SGTC_2119 5528445 120.635 µM -0.500676627516392 0.294190762103335 no 2339 0.308299361948018 3399 791935
SGTC_2927 9011802 47.9 µM -0.501736781871579 0.293766960152473 no 2340 0.307926343772674 3368 43912568
SGTC_2656 pseudo-anisatin 100 µM -0.502399129752754 0.293502326769789 no 2341 0.307693395539149 3314 6708809 A neurotoxin.
SGTC_191 3914-0123 66.505 µM -0.503366904925156 0.293115862111522 no 2342 0.30735316767784 3239 3144412
SGTC_1214 0358-0031 63.7 µM -0.503967016920586 0.292876336135379 no 2343 0.307142277492645 3440 4301366
SGTC_1255 0566-0045 221 µM -0.504329394399798 0.292731742442828 no 2344 0.307014962383874 3407 2788469
SGTC_1195 1502-0147 41.1 µM -0.505181680882457 0.292391798934234 no 2345 0.306715617883469 3341 817940
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.505672010856323 0.292196308831663 no 2346 0.306543460015723 3310 65057 A dermal irritant. YDR527W RBA50
SGTC_2666 tannic acid 100 µM -0.506562758523519 0.291841331501834 no 2347 0.306230822249413 3406 16134267 A thiamine antagonist.
SGTC_2154 5570129 200 µM -0.50748574384095 0.291473719020837 no 2348 0.305907018386303 3384 673366
SGTC_2724 maprotiline 69.64 µM -0.507511969422885 0.291463276885195 no 2349 0.305897820080952 3408 4011 A tricyclic antidepressant.
SGTC_3344 9148862 3.898 µM -0.508318035965577 0.291142413716108 no 2350 0.305615161732231 3429 4905352
SGTC_3280 9140961 49.47 µM -0.50892564877121 0.290900656207292 no 2351 0.30540217045511 3260 4901226
SGTC_133 0724-0033 378.92 µM -0.509153508932642 0.290810019205136 no 2352 0.305322313822665 3217 280309
SGTC_1703 st026983 48.3 µM -0.509342336398018 0.290734918426503 no 2353 0.305256143738575 3412 1104023
SGTC_94 0334-0113 514.748 µM -0.510524897838914 0.290264794479707 no 2354 0.304841888064169 3332 6795178
SGTC_2343 7990716 14.84 µM -0.510772602853286 0.29016636517642 no 2355 0.304755147731659 3286 6456862
SGTC_2951 9072950 58.06 µM -0.510782794711999 0.290162315623473 no 2356 0.304751579023128 3397 16488155
SGTC_35 0133-0054 64.071 µM -0.510907474210994 0.290112778595974 no 2357 0.304707923643157 3323 99677
SGTC_2687 chenodiol 100 µM -0.511780940676912 0.289765848514383 no 2358 0.304402165400678 3392 5702181 A cholesterol synthesis inhibitor.
SGTC_983 1491-0821 12.2 µM -0.51189067008709 0.289722279116154 no 2359 0.304363764114688 3378 46495113
SGTC_2658 polymyxin b sulfate 77.05 µM -0.51275320544559 0.289379906059144 no 2360 0.304061983381869 3338 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2777 climbazole 1.536 µM -0.513579510398812 0.289052092615125 no 2361 0.303773003957815 3373 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_17 0960-0276 49.807 µM -0.514895161000911 0.288530505691576 no 2362 0.303313141255483 3341 6821114
SGTC_1885 st057546 99.9 µM -0.514945521653624 0.288510549132287 no 2363 0.303295544753034 3462 702008
SGTC_2305 7443522 69.23 µM -0.516473338111233 0.287905426373781 no 2364 0.302761927871844 3360 5415886
SGTC_2473 5854593 8.94 µM -0.517610440355394 0.287455443294355 no 2365 0.302365047984585 3257 2872951
SGTC_3196 9111891 49.47 µM -0.519678709826372 0.28663782514049 no 2366 0.301643764118724 3387 18891510
SGTC_558 k064-0027 21.3 µM -0.521107420204644 0.286073679178767 no 2367 0.301145971074551 3363 5088526
SGTC_123 0083-0120 66.675 µM -0.521123409452381 0.286067368590417 no 2368 0.301140402175882 3327 16001701
SGTC_1112 tnp00069 1.16933 µM -0.522183419469283 0.285649154636742 no 2369 0.300771314607979 3392 145826
SGTC_1197 1601-0112 267 µM -0.52326711021569 0.285221898717777 no 2370 0.30039419272509 3302 7350313
SGTC_5 0352-0601 109.883 µM -0.523875693455125 0.284982092287048 no 2371 0.300182500882034 3343 762456
SGTC_2784 7567673 72.73 µM -0.525392954444915 0.284384649077187 no 2372 0.299655025171314 3437 3471247
SGTC_3161 9100388 49.47 µM -0.525393822601039 0.284384307399691 no 2373 0.299654723477113 3377 25236368
SGTC_3123 9126162 49.47 µM -0.52676915274822 0.283843269468916 no 2374 0.299176953387705 3346 25239884
SGTC_751 0833-0568 350 µM -0.527304180897283 0.283632929196925 no 2375 0.298991185682829 3383 6954252
SGTC_2153 5569715 200 µM -0.527530670172719 0.2835439099976 no 2376 0.298912561879918 3376 2054701
SGTC_24 0417-1663 219 µM -0.527614805841758 0.283510844779012 no 2377 0.298883357299132 3395 4329390
SGTC_689 0833-0039 98 µM -0.527850009087842 0.283418419985686 no 2378 0.298801722083295 3379 5374726
SGTC_2111 5486399 200 µM -0.528181826736216 0.283288054441507 no 2379 0.298686570816803 3386 689674
SGTC_2525 harmine 47.85 µM -0.528601178250117 0.283123339472066 no 2380 0.298541071385927 3313 5280953 A monoamine oxidase inhibitor
SGTC_488 nitrendipine 139 µM -0.528926786173705 0.282995477278358 no 2381 0.298428119746397 3397 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_290 2043-6722 48.1 µM -0.52893384825713 0.282992704392936 no 2382 0.298425670163075 3405 773758 YLR208W SEC13
SGTC_859 0439-0102 54.6 µM -0.529541430228343 0.282754189760372 no 2383 0.298214956047037 3447 610143
SGTC_517 1365-0151 113 µM -0.529883131206239 0.282620092802581 no 2384 0.298096481287986 3455 768657
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.53065968869997 0.282315454697306 no 2385 0.297827312607892 3470 688664
SGTC_1612 st002233 45.4 µM -0.531506381275221 0.281983483232941 no 2386 0.297533960235702 3438 1035021
SGTC_2268 7933382 153.85 µM -0.532613991110902 0.281549495323479 no 2387 0.297150407516204 3422 935025 YOR257W CDC31
SGTC_3179 9107801 49.47 µM -0.533199238891577 0.281320311472016 no 2388 0.29694783416671 3347 4818259
SGTC_1326 1431-2094 10.8 µM -0.53424363729355 0.280911547478275 no 2389 0.296586490874548 3310 616278
SGTC_1372 2752-0194 270 µM -0.534449564030121 0.280830984319907 no 2390 0.296515267662405 3408 823334
SGTC_635 k038-0028 24.7 µM -0.534653578703253 0.280751180221097 no 2391 0.296444713498815 3354 4035102
SGTC_68 0986-0284 82.829 µM -0.535149884500784 0.280557086868426 no 2392 0.296273108761696 3405 423278 YIL048W NEO1
SGTC_375 3970-0961 9.27 µM -0.535163473801848 0.280551773330553 no 2393 0.296268410709822 3348 2898222
SGTC_140 0062-0056 502.533 µM -0.5351807844526 0.280545004782306 no 2394 0.296262426173723 3320 3758964
SGTC_1768 st044301 37.178 µM -0.535704434442132 0.280340292462684 no 2395 0.296081419198645 3352 3931349
SGTC_2528 xanthyletin 44.79 µM -0.536675659643352 0.27996079961708 no 2396 0.295745835995195 3329 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2939 9044578 71.43 µM -0.53678786378615 0.279916973451946 no 2397 0.295707077851634 3362 2653634
SGTC_2155 5570423 76 µM -0.537062163376309 0.279809847932176 no 2398 0.295612337677713 3319 797402
SGTC_957 1187-1561 14.1 µM -0.538035558890212 0.279429856661222 no 2399 0.295276249843089 3413 1538454
SGTC_2779 methotrexate 400 µM -0.538670995445314 0.27918193210279 no 2400 0.295056945254202 3468 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2884 9058502 51.95 µM -0.539296928190764 0.278937820176904 no 2401 0.294840994038357 3440 6471554
SGTC_2440 5628896 157.78 µM -0.53986625552774 0.278715874408014 no 2402 0.294644635382578 3363 5522048
SGTC_2301 7769476 200 µM -0.540225044554152 0.278576048774162 no 2403 0.294520921517862 3379 977820
SGTC_693 4161-2696 114 µM -0.541699216550871 0.278001899978538 no 2404 0.294012864773727 3407 805759
SGTC_377 3970-0964 33.1 µM -0.544087258259475 0.277073051514583 no 2405 0.293190714078419 3420 16481235
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.544133430930454 0.277055107252386 no 2406 0.293174828343701 3398 2333 A French combination drug.
SGTC_479 n-linoleoylglycine 10 µM -0.544892628221786 0.276760139089737 no 2407 0.292913683317301 3385 6433346 An anti-infammatory.
SGTC_1727 st034309 9.9045 µM -0.545297539356215 0.276602883371692 no 2408 0.292774448093745 3505 870305
SGTC_25 0118-0223 35.662 µM -0.546136303193673 0.276277271262966 no 2409 0.292486123429101 3483 5333628
SGTC_731 3966-0296 387 µM -0.546308249226469 0.276210544232065 no 2410 0.292427033367776 3417 660956
SGTC_962 1254-0300 21.5 µM -0.546576143611859 0.276106598323959 no 2411 0.29233498126547 3380 7340576
SGTC_711 k292-0785 179 µM -0.547686071904588 0.275676138904394 no 2412 0.291953738673297 3428 4146315
SGTC_1978 st071761 42 µM -0.549661778210327 0.274910725202698 no 2413 0.291275688659652 3349 5147680
SGTC_1692 fluoroquinolonic acid 71 µM -0.549786282165842 0.274862525889784 no 2414 0.291232984313508 3447 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2597 laccaic acid a 100 µM -0.551013533768184 0.274387642017963 no 2415 0.29081219853174 3411 5491415 A textile dye.
SGTC_74 000s-0487 160.283 µM -0.551647177209703 0.274142612904144 no 2416 0.290595053544181 3435 677548
SGTC_2695 st077686 51.995 µM -0.553341046393851 0.2734881270032 no 2417 0.290014949681483 3396 2876092
SGTC_2867 9039098 71.43 µM -0.553768536456413 0.273323073507379 no 2418 0.28986863186946 3420 6463460
SGTC_1842 st055362 61.2 µM -0.553987442534432 0.27323857318809 no 2419 0.289793719889626 3392 676032
SGTC_516 3992-2719 87.3 µM -0.554960102569863 0.272863271558016 no 2420 0.289460975205995 3285 5350887 YDR037W KRS1
SGTC_2622 2-methoxyxanthone 59.94 µM -0.555178554862769 0.27277901674397 no 2421 0.289386267881672 3374 71034 A hepatoprotective.
SGTC_3145 9085516 49.47 µM -0.555623524275872 0.272607436525195 no 2422 0.289234123211002 3420 25236195
SGTC_2431 5490079 200 µM -0.556733654628964 0.272179603913701 no 2423 0.288854709634015 3402 5722345
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.557108919988668 0.272035056086803 no 2424 0.288726506729004 3408 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2933 9026794 32.47 µM -0.557312410653836 0.271956689828107 no 2425 0.288656998876265 3361 17586027
SGTC_1719 st032227 49.2 µM -0.557518179791789 0.271877457526709 no 2426 0.288586720763441 3397 3125804
SGTC_2159 5658611 73.75 µM -0.558139718505666 0.271638201098907 no 2427 0.288374490233873 3486 793844
SGTC_1931 st074438 57.1 µM -0.558751413300355 0.271402836406123 no 2428 0.288165692879008 3430 2787313
SGTC_2587 piperic acid 92.2 µM -0.558986006554043 0.271312597817308 no 2429 0.288085635186837 3351 5370536
SGTC_245 methotrexate 289.6 µM -0.560499094046866 0.27073093341446 no 2430 0.287569528717834 3429 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2991 9074669 71.4286 µM -0.562243243804804 0.270061216950752 no 2431 0.286975150969915 3487 17333109
SGTC_2112 5488546 200 µM -0.562447562976543 0.269982816999495 no 2432 0.286905560430665 3368 600757
SGTC_1724 st037281 8.293 µM -0.562588725035393 0.269928657916203 no 2433 0.286857485698562 3424 574124 YDL195W SEC31
SGTC_881 0833-0569 170 µM -0.563264687977435 0.26966938930376 no 2434 0.286627329898673 3367 5418700
SGTC_2944 9067346 25.62 µM -0.564852970775126 0.269060687643607 no 2435 0.286086887033698 3452 6473075
SGTC_3248 9135562 49.47 µM -0.566304639772555 0.268504946334391 no 2436 0.285593353444002 3466 17650701
SGTC_1762 st045503 25.4615 µM -0.569014865379689 0.267468939489335 no 2437 0.284673025909646 3445 4645554
SGTC_1104 tacrolimus 29.8 µM -0.570002961732705 0.267091733320937 no 2438 0.284337844651603 3495 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3055 9094636 49.47 µM -0.570528609266048 0.266891176672717 no 2439 0.284159611804469 3534 25236176
SGTC_914 3820-6779 408 µM -0.571355559620625 0.266575814390799 no 2440 0.283879323515157 3412 2893481
SGTC_194 1486-1323 56.904 µM -0.572631921395151 0.266089436624338 no 2441 0.28344697070392 3442 5178754
SGTC_378 3970-0959 8.33 µM -0.573158554336294 0.26588888589302 no 2442 0.283268671906215 3473 6615653
SGTC_3134 9127454 49.47 µM -0.576049663497763 0.264789268791858 no 2443 0.282290806740764 3564 24262820
SGTC_3187 9109394 49.47 µM -0.576551552904392 0.264598613772232 no 2444 0.282121217369123 3413 17098090
SGTC_1234 0326-0494 15.5 µM -0.577311234243508 0.264310163062959 no 2445 0.281864612971772 3540 1547813
SGTC_1518 st038567 90.8 µM -0.5777708671498 0.264135718397228 no 2446 0.281709413257084 3494 77966
SGTC_2817 7995342 71.43 µM -0.578201554664056 0.263972312630727 no 2447 0.281564024645999 3356 18879975
SGTC_1420 4'-methoxyflavone 42 µM -0.578346934810945 0.263917166049245 no 2448 0.281514956359519 3481 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2869 9037858 32.47 µM -0.57844638592977 0.263879444960612 no 2449 0.281481392282003 3463 27187042
SGTC_2400 5203494 178.7 µM -0.579470748082064 0.263491071840692 no 2450 0.281135789414524 3473 6777674
SGTC_3278 9139605 49.47 µM -0.579881672995807 0.263335357221969 no 2451 0.280997207760205 3546 7958859
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.581178575135665 0.262844221488139 no 2452 0.28056005288484 3500 66535 A nucleotide analog.
SGTC_947 3447-0010 211 µM -0.581261723659595 0.262812749199144 no 2453 0.280532036724767 3496 748350
SGTC_3257 9139206 32.98 µM -0.581328910279319 0.262787320008706 no 2454 0.280509399776274 3472 4910041
SGTC_3103 9120822 49.47 µM -0.581567816539327 0.262696907544479 no 2455 0.280428913102864 3591 17141819
SGTC_804 1595-0054 20.9 µM -0.583153230078741 0.262097321956241 no 2456 0.279895076359351 3407 761523 Stimulates phospholipase C.
SGTC_2478 5763493 32.33 µM -0.583564878722159 0.261941755840227 no 2457 0.27975654762848 3454 1365576 YLR208W SEC13
SGTC_2701 st077767 14.721 µM -0.583719989544969 0.26188315020097 no 2458 0.279704358089717 3471 5721188
SGTC_1316 1272-0050 65.9 µM -0.58573888220362 0.261120964293339 no 2459 0.279025500378144 3507 7340392
SGTC_1937 st074714 47.2 µM -0.587154993783039 0.260587025517524 no 2460 0.278549807954477 3376 17250970
SGTC_2630 antimycin a 100 µM -0.587578057818064 0.260427620152696 no 2461 0.278407771280071 3448 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_214 4373-3496 70 µM -0.588131942117024 0.260218999252351 no 2462 0.278221867258731 3567 3779166
SGTC_428 3448-4153 16.5 µM -0.588508609569208 0.260077176414514 no 2463 0.278095478341476 3405 3834874
SGTC_1243 0416-0003 5.65 µM -0.588707080503477 0.260002464167996 no 2464 0.278028893660836 3432 2141977
SGTC_836 0330-0104 1.35 µM -0.589579528414512 0.259674171854267 no 2465 0.277736289859241 3499 46494820
SGTC_1159 4092-0538 61.2 µM -0.589608328503628 0.259663338354681 no 2466 0.277726633376775 3525 717301
SGTC_3166 9102297 49.47 µM -0.589679612573249 0.259636524998737 no 2467 0.277702732997318 3455 25237072
SGTC_1818 st052136 56.3 µM -0.589820291280825 0.259583613186811 no 2468 0.27765556868159 3466 674169
SGTC_2244 6635614 200 µM -0.590152784709172 0.259458578514438 no 2469 0.277544111610757 3335 836499
SGTC_606 k015-0008 38.6 µM -0.590691052438852 0.259256228056259 no 2470 0.277363722090696 3545 1970475
SGTC_2804 7954240 19.48 µM -0.59153153278397 0.258940430285482 no 2471 0.277082166830266 3510 828705
SGTC_905 2-aminofluorene 215 µM -0.592061469983618 0.258741416735574 no 2472 0.27690471336306 3547 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1037 k284-1091 78.7 µM -0.593591350143517 0.258167327335893 no 2473 0.276392733900643 3513 3334711
SGTC_2070 5230947 200 µM -0.593789914438452 0.258092864289323 no 2474 0.276326317758339 3568 2835538
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.593826113525434 0.258079290570277 no 2475 0.276314210666479 3499 442882
SGTC_747 3448-8087 38.7 µM -0.59433466927668 0.257888634490506 no 2476 0.27614414739513 3464 5168703
SGTC_654 1124-0271 80.9 µM -0.596167266471178 0.257202205763451 no 2477 0.275531745357717 3474 5403748
SGTC_888 0916-0002 6.97 µM -0.596679829713837 0.257010387099045 no 2478 0.275360580865128 3553 2802138 YIL048W NEO1
SGTC_2404 5161160 200 µM -0.597626814861979 0.256656188775429 no 2479 0.275044483966567 3504 2831543
SGTC_1681 tripelennamine 100 µM -0.598408790063242 0.256363900401577 no 2480 0.274783601018341 3524 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1623 st003709 20.3 µM -0.598525293932164 0.256320368187546 no 2481 0.274744743384672 3520 16192618
SGTC_1461 k072-0203 53.8 µM -0.598665691802434 0.25626791298813 no 2482 0.274697919964598 3458 5418714
SGTC_1377 2944-0135 198 µM -0.599563405281126 0.25593264322712 no 2483 0.274398620904213 3529 1894137
SGTC_695 3505-6186 243 µM -0.599595620537039 0.255920616025586 no 2484 0.274387883280626 3511 1819379
SGTC_2846 9008642 19.48 µM -0.600338987259321 0.255643170408693 no 2485 0.274140170344073 3517 2992898
SGTC_1896 st058441 89 µM -0.600913384049828 0.255428896808355 no 2486 0.273948839139681 3444 688759
SGTC_1848 st056003 16.4 µM -0.601389569547803 0.255251331233112 no 2487 0.273790272111972 3562 146492
SGTC_3141 9094609 49.47 µM -0.602385481842007 0.254880172632935 no 2488 0.273458785859091 3416 25236309 YDL196W YDL196W
SGTC_486 niguldipine 82 µM -0.606586965603244 0.253317470086376 no 2489 0.27206252626586 3510 1236 A calcium channel blocker.
SGTC_1367 1812-0510 76.9 µM -0.607018100627792 0.25315739887928 no 2490 0.27191944995535 3479 1142582 YDR527W RBA50
SGTC_2287 7945887 168.79 µM -0.607970143994972 0.252804114085076 no 2491 0.271603637836501 3521 1245853
SGTC_950 1165-0508 94.1 µM -0.608484520541346 0.252613347001425 no 2492 0.271433084717988 3486 6148369
SGTC_1429 4049-0205 9.46 µM -0.608594011925812 0.252572749668248 no 2493 0.271396787274456 3557 22774478
SGTC_331 k048-0133 24.5 µM -0.609190936524754 0.252351481786965 no 2494 0.271198943591206 3520 6813582
SGTC_2968 9090663 33.37 µM -0.609523933593851 0.252228090921554 no 2495 0.27108860685693 3436 25236811
SGTC_1666 st014829 29 µM -0.60958619566658 0.252205023465608 no 2496 0.271067979148648 3546 3858230
SGTC_2276 7947513 42.08 µM -0.611356313947781 0.251549678601304 no 2497 0.270481858614971 3440 2105100
SGTC_355 1311-2252 105 µM -0.613042817488337 0.250926128094922 no 2498 0.269924014258499 3481 5338538
SGTC_1788 fluconazole 20 µM -0.613549100763204 0.250739099893108 no 2499 0.269756663520462 3523 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1292 0kpi-0043 232 µM -0.614307074651853 0.250459231665279 no 2500 0.269506214211455 3495 3333905
SGTC_877 0771-0151 33.1 µM -0.614367741505721 0.250436838677947 no 2501 0.269486173741528 3492 6166523
SGTC_2185 6113692 200 µM -0.614715259543937 0.250308585342771 no 2502 0.269371390280257 3538 874150
SGTC_2972 9093619 59.92 µM -0.616226506822768 0.249751256918738 no 2503 0.268872518152966 3483 25236256
SGTC_2017 5132927 60.65 µM -0.61702706691179 0.249456287930358 no 2504 0.268608436394309 3494 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2853 9015042 58.44 µM -0.61748208617153 0.249288717148414 no 2505 0.268458396742812 3482 6457456
SGTC_3308 9128332 17.569 µM -0.618372020357814 0.248961152516112 no 2506 0.268165068566817 3560 17332805 YDL196W YDL196W
SGTC_76 0433-0009 400.328 µM -0.618682588612379 0.248846893309689 no 2507 0.268062741200276 3526 2841569
SGTC_2957 9076800 11.52 µM -0.618840356467676 0.248788860627813 no 2508 0.268010766697426 3474 16459615
SGTC_1821 st053465 65.6 µM -0.619025856453091 0.248720636290603 no 2509 0.267949662706976 3511 675086
SGTC_908 3448-7491 47.7 µM -0.620799294579613 0.248068893433784 no 2510 0.267365843725652 3577 1203031
SGTC_2534 helenine 20.12 µM -0.621026218695702 0.247985564063509 no 2511 0.267291186238848 3546 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1190 1486-1332 13 µM -0.621941849538726 0.247649484757886 no 2512 0.266990052790447 3532 4150046
SGTC_3033 9090887 49.47 µM -0.622475971173866 0.247453549559422 no 2513 0.266814469575524 3515 19325384
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.622587531141715 0.247412635775662 no 2514 0.266777803540497 3559 616764
SGTC_2931 9014674 55.67 µM -0.622670708044136 0.247382133621656 no 2515 0.26675046772814 3520 2996810
SGTC_390 dec-rvkr-cmk 16.7 µM -0.622956097175999 0.247277492645935 no 2516 0.266656686301944 3555 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2897 9048598 12.99 µM -0.624542590230411 0.246696219699033 no 2517 0.266135654534476 3512 6467404
SGTC_1557 sumaresinolic acid 42.3 µM -0.624553986630885 0.246692046836572 no 2518 0.266131913625057 3516 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2733 amorolfine 100 µM -0.625336269455047 0.246405699515287 no 2519 0.265875190136001 3547 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_484 loperamide 105 µM -0.625744080374286 0.246256494802722 no 2520 0.265741407703669 3510 3955 An opioid-receptor agonist.
SGTC_2654 protoveratrine a 100 µM -0.625887814744315 0.246203918632685 no 2521 0.265694263757311 3529 5702278 A heart drug and vasodilator.
SGTC_544 k015-0020 52.4 µM -0.626141644871345 0.246111085564004 no 2522 0.26561101947078 3551 3008304
SGTC_2787 5284540 71.43 µM -0.627146595541185 0.245743730223973 no 2523 0.26528157304472 3541 736958
SGTC_785 1270-0111 65.3 µM -0.627927223316927 0.245458578428647 no 2524 0.265025808160432 3554 6741994
SGTC_2833 9001315 45.46 µM -0.628239238135912 0.245344653776339 no 2525 0.264923614680826 3482 2989378
SGTC_3185 9108267 49.47 µM -0.62830871234282 0.245319290821886 no 2526 0.264900862683575 3549 4910486
SGTC_1611 st001856 99.4 µM -0.628953492707758 0.245083968052485 no 2527 0.264689751978579 3514 647478
SGTC_2012 4023501 200 µM -0.62903633452531 0.245053742428165 no 2528 0.264662634536426 3498 3477460
SGTC_3068 9116768 49.47 µM -0.632039527858915 0.243959353988426 no 2529 0.26368052421551 3556 41904888
SGTC_3163 9099914 49.47 µM -0.633708075337242 0.243352462900791 no 2530 0.263135676940331 3585 16268368
SGTC_1667 st014849 34.6 µM -0.634333538083216 0.243125177382367 no 2531 0.262931586744059 3601 5348460
SGTC_1392 3455-1037 33.9 µM -0.634590099892797 0.243031979166222 no 2532 0.262847893339661 3599 981132
SGTC_1781 st038725 66.3 µM -0.634940508842936 0.242904721418324 no 2533 0.262733607935012 3564 4270275 YIL048W NEO1
SGTC_88 0180-0332 8.668 µM -0.636407966190794 0.242372177930435 no 2534 0.262255274987948 3614 3101745
SGTC_1775 st081588 35.1725 µM -0.638042078529888 0.241779900222986 no 2535 0.261723144594284 3612 1426443 YGL099W LSG1
SGTC_866 0495-0101 262 µM -0.639854488808852 0.241123918873856 no 2536 0.261133602092474 3526 635694
SGTC_235 0330-0087 5 mM -0.64043346471695 0.240914569205832 no 2537 0.26094541621765 3592 46494818 YHR062C RPP1
SGTC_36 0335-0881 14.2 µM -0.642406604128843 0.24020185253735 no 2538 0.260304606407784 3537 23828853
SGTC_1272 0839-0021 27 µM -0.643364743274375 0.239856178507335 no 2539 0.259993727502925 3575 5027250
SGTC_3093 9117344 49.47 µM -0.644558453762151 0.23942589579464 no 2540 0.259606682894412 3589 24824913
SGTC_1106 tegaserod maleate 11.7 µM -0.644643624214957 0.239395211527535 no 2541 0.259579078891575 3574 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2719 novobiocin 32.65 µM -0.646408473739683 0.238759874683049 no 2542 0.259007427036125 3597 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2210 7115885 190.385 µM -0.64748182615457 0.238373924844207 no 2543 0.258660076467936 3596 2927039
SGTC_2408 sulbentine 18.36 µM -0.649011787759747 0.237824381209905 no 2544 0.258165378520904 3532 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1966 st070145 16.1 µM -0.64924220867448 0.237741677057493 no 2545 0.258090916721362 3551 3748532
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.650510660370483 0.237286678835426 no 2546 0.257681208997569 3617 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2585 alliin 100 µM -0.650735938380644 0.237205920836257 no 2547 0.257608479913033 3670 87310 A garlic compound which reacts with lipids.
SGTC_2043 5101342 149 µM -0.653205309667608 0.236321687441256 no 2548 0.256811963822293 3573 678451
SGTC_2418 pentamidine 31.67 µM -0.654023189377367 0.236029221359642 no 2549 0.256548432843157 3593 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_427 1354-0053 47.3 µM -0.654834947782529 0.23573914151439 no 2550 0.25628701357405 3655 6813657
SGTC_362 0310-0100 9.03 µM -0.655580319901289 0.235472957867584 no 2551 0.256047095738271 3618 790235
SGTC_647 0140-0236 81 µM -0.656112337676715 0.235283067764025 no 2552 0.255875923351611 3620 990837
SGTC_315 k915-0449 187 µM -0.656798264341053 0.235038368644692 no 2553 0.255655320200004 3633 20970215 YNL149C PGA2
SGTC_95 0471-0001 561.058 µM -0.656850581178296 0.235019710783279 no 2554 0.255638498485856 3549 4015405
SGTC_346 4513-0042 7.16 µM -0.658324667203791 0.234494340916055 no 2555 0.255164765374624 3608 2827372
SGTC_690 glyoxal 20.3 µM -0.658349806112742 0.234485386951423 no 2556 0.255156690362977 3531 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2146 5545642 200 µM -0.658468359425243 0.234443163238435 no 2557 0.25511861098176 3631 825326
SGTC_2486 5283202 22.39 µM -0.659542785460358 0.234060689676831 no 2558 0.254773640399535 3578 1377751
SGTC_2366 9070441 60.58 µM -0.659806072597409 0.233967017619284 no 2559 0.254689142937275 3603 6837235
SGTC_2036 5160441 105 µM -0.662120009314336 0.233144661246372 no 2560 0.253947156599812 3627 134534 YIL048W NEO1
SGTC_1011 4112-3381 17.4 µM -0.66336875914015 0.23270153211165 no 2561 0.253547204591207 3666 2877139
SGTC_2228 7354201 200 µM -0.664950810540005 0.232140800992967 no 2562 0.253040977716981 3642 753451
SGTC_1513 0337-0559 19 µM -0.665142287898211 0.232072986167233 no 2563 0.252979744636308 3533 775073
SGTC_2553 4-methylesculetin 85.09 µM -0.66546142428675 0.231959983328514 no 2564 0.252877704447229 3622 5319502
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.666366490587232 0.231639675594769 no 2565 0.252588437790697 3621 688664
SGTC_1047 2043-3044 82 µM -0.669266245450093 0.23061509893578 no 2566 0.251662827397569 3616 669592
SGTC_60 0986-0278 202 µM -0.670313271712086 0.230245774058615 no 2567 0.251329054246134 3465 3110598
SGTC_2323 6148992 148.28 µM -0.670560684397907 0.230158550801084 no 2568 0.251250217727038 3590 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1787 fluconazole 80 µM -0.670753975066049 0.230090420668336 no 2569 0.251188635953202 3554 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1411 3909-8223 150 µM -0.671817017127771 0.229715926642655 no 2570 0.250850096960366 3638 X1411
SGTC_455 paf C-16 10 µM -0.673820080767613 0.229011205376869 no 2571 0.250212853307624 3604 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2388 9080168 200 µM -0.677966968369509 0.227556102392602 no 2572 0.248896318516292 3605 15943073
SGTC_889 0919-1524 82.7 µM -0.678224976781337 0.227465742084487 no 2573 0.248814529203905 3628 3905452
SGTC_1166 k206-0078 225 µM -0.681410349122875 0.226351819929409 no 2574 0.247805938111591 3653 5404595
SGTC_1729 st035615 45.989 µM -0.681616619241632 0.226279793807939 no 2575 0.24774070170364 3642 17385451
SGTC_92 0063-0024 660.874 µM -0.681904035951532 0.226179454228917 no 2576 0.247649816609546 3697 3594437
SGTC_1401 3807-4679 7.6 µM -0.682178295951608 0.226083731213583 no 2577 0.24756310845354 3631 3291456
SGTC_679 0422-0091 41.4 µM -0.682557135385812 0.225951545248821 no 2578 0.24744336386175 3665 627384 YHR062C RPP1
SGTC_2170 morpholine 200 µM -0.68276853104987 0.225877803341579 no 2579 0.247376558806405 3666 121171 Reacts with secondary amines.
SGTC_1308 1187-1617 41.4 µM -0.682866410914038 0.225843664167743 no 2580 0.247345630170964 3654 2882570
SGTC_1564 D-Arginine 115 µM -0.683856576220694 0.225498472004154 no 2581 0.247032868368857 3614 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1693 xanthone 101.9 µM -0.685329855535974 0.224985409455173 no 2582 0.24656789808167 3695 7020 An insecticide.
SGTC_913 3487-1245 167 µM -0.685761048991703 0.224835373620403 no 2583 0.24643190119114 3620 4016153
SGTC_1511 0906-3109 28.5 µM -0.685973363941857 0.224761518460752 no 2584 0.246364952579174 3705 2882180
SGTC_482 fipronil 114 µM -0.687517031799339 0.224224957195162 no 2585 0.245878485845617 3688 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1027 k015-0025 8.67 µM -0.687686336658723 0.224166153057523 no 2586 0.245825163023618 3634 3598955
SGTC_175 3793-3120 23.7 µM -0.688295271197344 0.223954726103493 no 2587 0.245633429490929 3658 5322297
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.688840103801074 0.223765651935025 no 2588 0.245461947658348 3750 5282309
SGTC_1148 3909-7663 27.7 µM -0.6890106038231 0.223706501674549 no 2589 0.245408297317593 3705 4084526
SGTC_2438 5259590 200 µM -0.690092300829428 0.223331444024252 no 2590 0.245068072295769 3673 1201127
SGTC_719 2810-4230 27.3 µM -0.690483655340442 0.223195837571335 no 2591 0.244945042502948 3636 721079
SGTC_306 1672-3436 11.6 µM -0.698047748533373 0.220584063034852 no 2592 0.242573666755774 3686 6797378
SGTC_1816 st051957 91.6 µM -0.700151660711196 0.219860736533841 no 2593 0.241916298083308 3679 674121
SGTC_2328 6201408 200 µM -0.700844616702086 0.219622796130151 no 2594 0.241699995315852 3656 2890418
SGTC_1457 k015-0032 57.3 µM -0.70236134155169 0.219102514474062 no 2595 0.241226923771844 3676 4302660
SGTC_1600 coumarin 106 71.1 µM -0.702543265769781 0.219040156702289 no 2596 0.241170214820921 3744 100336 A hepatotoxic, DNA x-linker.
SGTC_3062 9077494 49.47 µM -0.703866246134644 0.218586988669159 no 2597 0.24075803682369 3649 16459633
SGTC_2700 st077718 96.8 µM -0.704860234113625 0.218246867684519 no 2598 0.240448609646688 3681 904970
SGTC_348 k064-0012 10.7 µM -0.705550401216889 0.218010887049795 no 2599 0.240233888985367 3627 5066323
SGTC_429 1112-0049 25.5 µM -0.705581786866909 0.218000159225547 no 2600 0.240224126954173 3663 2836170
SGTC_1679 SEC14.276 6.7 µM -0.705749237577084 0.217942928601147 no 2601 0.240172047599905 3720 1005053 YMR079W SEC14
SGTC_1683 st010134 710 nM -0.70601852220076 0.217850911765536 no 2602 0.240088309477371 3713 3818134
SGTC_3036 9090181 49.47 µM -0.706580499735147 0.217658951475169 no 2603 0.239913605351231 3700 25236586
SGTC_3208 9114115 49.47 µM -0.70757754920798 0.217318619606126 no 2604 0.239603819435935 3680 650895
SGTC_1018 4259-0013 28.1 µM -0.707976950144053 0.217182374744091 no 2605 0.239479785784593 3734 6801262
SGTC_272 doxorubicin 8.13 µM -0.709346572858867 0.21671553977256 no 2606 0.23905471688519 3697 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1147 3809-1045 12.3 µM -0.71013292724753 0.216447773865317 no 2607 0.238810854574739 3657 325925
SGTC_2195 6536160 144.242 µM -0.710664246376518 0.216266959868854 no 2608 0.238646160242851 3609 3834386
SGTC_1950 st077106 7.18 µM -0.711361471222409 0.216029818973919 no 2609 0.238430134028344 3697 13831864
SGTC_2118 5526350 200 µM -0.712636348102838 0.215596596165106 no 2610 0.238035406747468 3719 743594
SGTC_2337 9009472 200 µM -0.714439162814313 0.214984832669803 no 2611 0.2374778313216 3712 5742383
SGTC_2232 chlorophetanol 41.5365 µM -0.714737857798895 0.214883571554374 no 2612 0.237385520070634 3759 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2394 5221648 200 µM -0.715061457688272 0.214773898655399 no 2613 0.237285534233462 3773 788586
SGTC_2334 9017922 200 µM -0.716921140302594 0.214144254893561 no 2614 0.236711378460405 3743 3163164
SGTC_2198 6589944 200 µM -0.716964626654493 0.214129544325283 no 2615 0.236697961695235 3683 5290268
SGTC_3146 9095609 49.47 µM -0.717358578526831 0.213996305035337 no 2616 0.236576435500757 3764 17173999
SGTC_1575 cyproterone acetate 48 µM -0.718045607435728 0.213764059048685 no 2617 0.236364583127114 3678 9880 An androgen receptor antagonist and liver toxin.
SGTC_2058 5236698 133 µM -0.718769474948625 0.213519518883933 no 2618 0.236141484233782 3724 766665
SGTC_1660 st012960 28.1 µM -0.718909254886614 0.213472316585827 no 2619 0.236098416858152 3691 24207266
SGTC_581 0958-0271 211 µM -0.719897184611578 0.213138875953512 no 2620 0.235794150797693 3722 4591145
SGTC_1887 st057648 70.8 µM -0.72045742044517 0.212949923282457 no 2621 0.235621703509607 3724 688672
SGTC_1766 st045414 44.774 µM -0.721209659232899 0.212696366916058 no 2622 0.235390264872984 3751 253960
SGTC_1443 4112-3303 14 µM -0.721796124913475 0.212498809869526 no 2623 0.23520991613693 3710 704433
SGTC_2227 7312221 64.1025 µM -0.722882186449868 0.212133241967753 no 2624 0.234876134272999 3736 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3220 9131269 49.47 µM -0.724728317809539 0.211512679299877 no 2625 0.234309359528206 3757 17722206
SGTC_926 2268-1401 59.4 µM -0.726299052507263 0.210985526966853 no 2626 0.233827730043919 3713 2931578
SGTC_767 0929-0023 86 µM -0.726381515376811 0.210957873001253 no 2627 0.233802459877966 3786 1204563
SGTC_3193 9111931 49.47 µM -0.726483998327567 0.210923508252891 no 2628 0.233771056808491 3769 17087244
SGTC_2852 9023854 51.95 µM -0.727919848291046 0.210442381974266 no 2629 0.233331326163238 3796 19798528
SGTC_616 4092-0450 108 µM -0.729668458666892 0.209857326419348 no 2630 0.232796432680964 3761 787165
SGTC_1786 berberine 21.6 µM -0.730801716965266 0.209478668426809 no 2631 0.232450137334824 3692 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_667 1498-1044 59 µM -0.731119452157259 0.20937257508737 no 2632 0.232353096867246 3741 6739982
SGTC_2338 7999974 200 µM -0.731345142157592 0.209297235299286 no 2633 0.23228418189163 3770 315925
SGTC_952 1185-0122 232 µM -0.731351096092872 0.209295247973918 no 2634 0.232282363997383 3694 678600
SGTC_2581 avocatin a 64 µM -0.734068506321473 0.208389381098038 no 2635 0.231453493372081 3743 6710728 A skin care supplement.
SGTC_2037 5169046 200 µM -0.735596118713259 0.207881158302997 no 2636 0.230988262665583 3784 5718022
SGTC_2203 7227154 166.4 µM -0.737486389976285 0.207253296440459 no 2637 0.230413308392725 3740 896304
SGTC_1873 rapamycin 2 nM -0.73950472471637 0.206584137259885 no 2638 0.229800285911219 3720 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3054 9094397 49.47 µM -0.741255369635019 0.206004765671807 no 2639 0.229269308422647 3747 2598354
SGTC_2128 5255449 168.493 µM -0.741559771894786 0.205904122940029 no 2640 0.229177052275015 3744 736008
SGTC_2655 perillic acid 100 µM -0.741882465761566 0.205797464417292 no 2641 0.229079275170085 3756 5702197 An apoptosis inducer.
SGTC_1124 fisetin 1.16336 µM -0.742177495449657 0.205699978302052 no 2642 0.228989900866585 3758 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_126 0417-1624 672.48 µM -0.744876614852327 0.204809386290729 no 2643 0.228173156672562 3825 41912 YDL195W SEC31
SGTC_1097 itavastatin 7.23 µM -0.745348027408159 0.204654076211993 no 2644 0.228030677062459 3760 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1349 flufenamic acid 69 µM -0.746683093421307 0.204214609982272 no 2645 0.2276274387056 3709 3371 A non-steroidal anti-inflammatory.
SGTC_3335 9143315 29.6265 µM -0.746942554681853 0.204129267892035 no 2646 0.227549118613438 3750 4899691
SGTC_2105 5350118 200 µM -0.747076800015636 0.204085120209345 no 2647 0.227508601732014 3768 2133313
SGTC_2419 paclitaxel 166.5 µM -0.747192404156668 0.204047107394504 no 2648 0.227473714246369 3696 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1919 st067113 52.3 µM -0.747891910299508 0.20381718661823 no 2649 0.227262678740156 3784 1268243
SGTC_3258 9138477 49.47 µM -0.74798236916825 0.203787464959759 no 2650 0.227235396069054 3797 4970355
SGTC_2665 lovastatin 100 µM -0.748197800488499 0.203716692076135 no 2651 0.227170428757928 3768 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_420 mitomycin C 81.9 mM -0.749420967358302 0.203315138654916 no 2652 0.226801758637331 3733 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_554 4483-2211 187 µM -0.749682585846822 0.203229313284685 no 2653 0.226722949036729 3774 747107
SGTC_174 3553-0389 74.3 µM -0.750690821253816 0.202898758471066 no 2654 0.226419374138033 3737 738071
SGTC_1853 st056710 91.2 µM -0.751768829540001 0.202545683770001 no 2655 0.226095045032368 3842 269167
SGTC_369 0957-0393 4.5 µM -0.752452306968842 0.202322018176836 no 2656 0.225889550395093 3778 6997992
SGTC_618 k072-0232 33.2 µM -0.753565756661696 0.201957962176017 no 2657 0.225555006381951 3769 5872756 YGL099W LSG1
SGTC_1053 3366-3204 134 µM -0.754304859781499 0.201716520046135 no 2658 0.225333092434342 3779 3632071 YPR165W RHO1
SGTC_69 0096-0274 206.684 µM -0.754446276032801 0.201670343441239 no 2659 0.225290646637396 3861 6741392
SGTC_448 monastrol 171 µM -0.754727558627739 0.201578515146077 no 2660 0.225206233706681 3678 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1175 0741-0056 27.6 µM -0.755603949853174 0.201292566694171 no 2661 0.224943343523516 3830 765927
SGTC_2264 7948757 110.76 µM -0.755667164888024 0.201271950334011 no 2662 0.224924387702064 3756 2971411
SGTC_1122 capsaicin 818.572 nM -0.756111941097294 0.201126930971829 no 2663 0.224791041574542 3861 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2682 pyrogallin 40.03 µM -0.75902334703099 0.200179215080563 no 2664 0.223919295370739 3804 822798 An ATP competetive kinase inhibitor.
SGTC_579 4491-1009 110 µM -0.759178684805618 0.200128725325806 no 2665 0.223872837484624 3905 1271041
SGTC_1042 0350-0096 82 µM -0.759449486899063 0.200040724272658 no 2666 0.223791860028489 3776 3122515
SGTC_752 1896-0090 130 µM -0.759848288947373 0.199911170148906 no 2667 0.223672637298797 3758 772567
SGTC_1613 st002381 52.1 µM -0.760169751838279 0.199806777023281 no 2668 0.223576561570052 3737 551167
SGTC_820 1582-0060 59.9 µM -0.762293721407033 0.199117855200548 no 2669 0.222942360173444 3787 3848840
SGTC_2280 7785178 200 µM -0.762767030581582 0.198964529829105 no 2670 0.222801173350797 3785 2954328
SGTC_777 1315-0167 517 µM -0.762784319795939 0.198958930449954 no 2671 0.222796016990505 3821 4221767
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.762884239247687 0.198926571852361 no 2672 0.222766218200867 3836 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.76418036108443 0.198507114394042 no 2673 0.222379884103148 3857 4213774
SGTC_1765 st044815 90.4 µM -0.7649992389783 0.198242380269272 no 2674 0.22213599889528 3810 645695
SGTC_1963 st076565 50.3 µM -0.766068503934908 0.197897019784658 no 2675 0.221817771206873 3792 4914280
SGTC_1448 4255-0083 152 µM -0.766777506582509 0.197668220474954 no 2676 0.221606906103723 3833 5399660
SGTC_527 4476-4215 268 µM -0.768159515998242 0.197222697731702 no 2677 0.221196210920122 3785 4418754
SGTC_2729 fluphenazine 10.66 µM -0.768236657396149 0.197197847329866 no 2678 0.221173299456256 3707 3372 An atypical antipsychotic.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.76897748874445 0.196959291698761 no 2679 0.22095333718435 3816 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1265 0819-1001 68.8 µM -0.77028529548672 0.196538590552652 no 2680 0.220565338492375 3764 3106768
SGTC_1252 0493-0875 34.8 µM -0.771293003745976 0.196214798136196 no 2681 0.220266639164683 3786 3960963
SGTC_295 k015-0027 31 µM -0.771402818662483 0.196179532441926 no 2682 0.220234102453133 3754 3887424
SGTC_2735 sertaconazole 140 nM -0.771763039591507 0.196063878956741 no 2683 0.220127393091612 3858 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_16 erodoxin 22.806 µM -0.771837386014537 0.196040014246827 no 2684 0.220105372912963 3816 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3316 9136639 10.545 µM -0.771979271867401 0.195994474717103 no 2685 0.220063352181045 3824 4903665
SGTC_2106 5357045 167.29 µM -0.772767952162961 0.195741457741486 no 2686 0.219829861540095 3822 668842
SGTC_343 4130-2827 29.8 µM -0.773435985859458 0.195527300632734 no 2687 0.219632199886614 3861 1118244
SGTC_2883 9059145 45.46 µM -0.7750447519626 0.195012149365102 no 2688 0.219156607994126 3786 16476510
SGTC_1440 4100-1550 40 µM -0.775857153888915 0.194752319820302 no 2689 0.218916666632608 3800 742806
SGTC_2022 5136654 200 µM -0.77679389924719 0.194452983210802 no 2690 0.218640188350214 3837 1713771
SGTC_951 1171-0579 82.7 µM -0.777323729062178 0.194283800370253 no 2691 0.218483899310275 3771 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2617 dihydrotanshinone i 20.83 µM -0.777409029772688 0.194256570915793 no 2692 0.218458743346246 3816 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1025 k007-0731 70 µM -0.777660943357459 0.194176169332572 no 2693 0.218384461451137 3779 6256118
SGTC_3112 9123419 49.47 µM -0.77905272034662 0.19373233056761 no 2694 0.217974329731602 3840 17015854
SGTC_3204 9114183 49.47 µM -0.77927480250774 0.193661565659621 no 2695 0.217908927211528 3825 17027248
SGTC_1904 st060225 78 µM -0.780093141266954 0.193400943884375 no 2696 0.217668026638145 3762 66595
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.78018199560251 0.193372658739084 no 2697 0.217641879166385 3792 688667
SGTC_529 4076-0302 30.3 µM -0.780348675589682 0.193319606036329 no 2698 0.217592834560953 3776 5816522
SGTC_3143 9086658 49.47 µM -0.780504453376434 0.19327003143394 no 2699 0.21754700363039 3883 25236626
SGTC_2471 5466956 24.79 µM -0.781134957978773 0.193069459401268 no 2700 0.217361561622205 3769 724419
SGTC_2725 haloperidol 53.21 µM -0.782038720768607 0.192782181989455 no 2701 0.217095909036821 3766 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2821 7996764 71.43 µM -0.782404186219987 0.19266608635447 no 2702 0.216988537189989 3833 2987135
SGTC_2887 9044784 58.44 µM -0.782550022253805 0.192619771258609 no 2703 0.216945699891132 3808 6465546
SGTC_532 1548-0774 215 µM -0.782817346157768 0.19253489130857 no 2704 0.216867189920001 3929 5932993
SGTC_2000 st075254 36.4 µM -0.783515150787322 0.192313434064476 no 2705 0.216662330100934 3765 17234175
SGTC_1363 1636-0063 10.4 µM -0.783964866175651 0.192170793707325 no 2706 0.216530363063447 3809 6072185
SGTC_1609 st001574 46.4 µM -0.78494410737581 0.191860422772799 no 2707 0.216243169904602 3816 3960012
SGTC_3035 9091303 49.47 µM -0.784978529402635 0.19184951828215 no 2708 0.216233078581001 3843 25237002
SGTC_212 3807-4682 38.772 µM -0.785046610962318 0.191827951967283 no 2709 0.216213120273104 3895 3125501 YBL034C STU1
SGTC_273 hydroxyurea 18.1 mM -0.787404784725752 0.191081865469315 no 2710 0.215522473352979 3873 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_441 propafenone 146 µM -0.787691397866252 0.190991307332 no 2711 0.215438619215455 3776 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1755 st041960 45.185 µM -0.788059169287822 0.190875145033704 no 2712 0.215331048404038 3855 2257073
SGTC_1744 st037937 38.9 µM -0.789409859841388 0.190448895237984 no 2713 0.214936247486093 3863 1016152
SGTC_2623 humulene 100 µM -0.789562928172155 0.190400626963394 no 2714 0.214891532821656 3771 6187145 An anti-inflammatory.
SGTC_1617 st002906 78 µM -0.78986718949125 0.190304704092906 no 2715 0.214802667368577 3832 5150859
SGTC_555 4296-0685 37 µM -0.790054475248653 0.190245674256714 no 2716 0.214747977527425 3770 2908540 YHR072W ERG7
SGTC_2013 4024628 200 µM -0.790425462005624 0.190128777664236 no 2717 0.214639668530234 3838 5230760
SGTC_1587 estradiol valerate 56.1 µM -0.791510600041204 0.189787108016549 no 2718 0.214323046504383 3824 13791 A steroid.
SGTC_1953 st076800 12.1 µM -0.792289607813782 0.189542060393165 no 2719 0.214095914902489 3861 297591
SGTC_1336 1486-0901 104 µM -0.793968884745563 0.189014483234012 no 2720 0.213606772819976 3840 5006114
SGTC_2214 7179297 48.276 µM -0.794001413905283 0.189004272511475 no 2721 0.213597304114814 3835 769744
SGTC_2094 5332512 191.667 µM -0.795266287205299 0.188607499323259 no 2722 0.213229309905657 3869 755774
SGTC_266 formosanin C 406 nM -0.796062458800608 0.188358014901713 no 2723 0.212997866518783 3762 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2730 imipramine 71.33 µM -0.797395821649014 0.187940655056349 no 2724 0.212610592591223 3822 3696 A tricyclic antidepressant.
SGTC_37 0566-0070 1.56 µM -0.798601982959673 0.18756360321473 no 2725 0.212260618738269 3840 1626686
SGTC_770 0389-1121 67.2 µM -0.798920059418154 0.187464248918311 no 2726 0.212168383369138 3964 6753108
SGTC_322 k048-0136 19.3 µM -0.799691351773306 0.187223463297904 no 2727 0.211944822405772 3878 6823282
SGTC_453 enantio-paf c16 10 µM -0.800654022318161 0.186923200794697 no 2728 0.211665983413034 3760 13871343 A lipid and platelet activating factor
SGTC_3356 9151811 4.48 µM -0.802015306038929 0.186499117448515 no 2729 0.211272052217663 3818 1859254 YPR165W RHO1
SGTC_2749 bexarotene 57.39 µM -0.802332083490099 0.186400516689649 no 2730 0.211180444123906 3868 82146 An retinoic acid receptor inhibitor.
SGTC_232 clozapine 119 µM -0.802450298473052 0.186363729142087 no 2731 0.211146263787796 3795 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2317 5986382 200 µM -0.804270211048819 0.185797954803164 no 2732 0.210620468835598 3869 877883
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.805889508308093 0.185295444441446 no 2733 0.210153280632179 3865 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3206 9114350 49.47 µM -0.807189855518718 0.184892524179955 no 2734 0.209778554702039 3769 17087243
SGTC_1504 k297-0033 30 µM -0.809448802853473 0.184193871694953 no 2735 0.209128520144576 3762 4388117
SGTC_1351 1496-0003 46.5 µM -0.810333169099702 0.183920800982036 no 2736 0.208874358354377 3898 3891978
SGTC_289 k017-0060 526 µM -0.810948300791302 0.183731012072209 no 2737 0.208697680394728 3834 5512909
SGTC_2552 juarezic acid 87.02 µM -0.811521749607925 0.183554193668682 no 2738 0.2085330539371 3877 1549512
SGTC_802 4112-3352 742 µM -0.812650652689541 0.18320641535501 no 2739 0.208209190749643 3950 704594
SGTC_93 0109-0045 59.227 µM -0.814447745041587 0.182653638145966 no 2740 0.20769424809224 3924 88733
SGTC_483 fpl-64176 144 µM -0.815404485624107 0.182359774480812 no 2741 0.20742040878941 3881 3423
SGTC_252 miconazole 1.30953 nM -0.81559504588415 0.182301279035554 no 2742 0.207365891929904 3794 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1342 1486-1464 234 µM -0.816933562803905 0.181890730875208 no 2743 0.206983198112032 3879 3253938
SGTC_1857 st056007 79.3 µM -0.817273961918191 0.181786416400976 no 2744 0.206885941693497 3861 619834
SGTC_162 k030-0015 37.8 µM -0.817616736012534 0.181681411944646 no 2745 0.206788034049219 3919 1809920 YMR134W ERG29
SGTC_1494 4358-1428 177 µM -0.818503228562442 0.181410022337845 no 2746 0.206534949628907 3863 1564571
SGTC_3109 9122853 49.47 µM -0.818988636385482 0.181261527846125 no 2747 0.206396448507494 3918 1234709
SGTC_3229 9132204 49.47 µM -0.821820412200949 0.180396757668912 no 2748 0.205589557293426 3879 17682924
SGTC_1482 3346-2049 8.48 µM -0.822894187781199 0.180069525104528 no 2749 0.205284084113773 3872 3826804
SGTC_1394 3474-0001 65.7 µM -0.824814174659737 0.179485339685888 no 2750 0.204738548989466 3861 5017666 YIL048W NEO1
SGTC_2773 thioridazine 9.09 µM -0.825917928876333 0.179150045469897 no 2751 0.204425324715855 3874 5452 An antipsychotic.
SGTC_2626 ethyl orsellinate 100 µM -0.82675862613651 0.178894926203152 no 2752 0.204186942436187 3890 75653 A natural product.
SGTC_878 0828-0289 13.7 µM -0.826807140089441 0.178880211066809 no 2753 0.204173191210724 3848 745350 YLR208W SEC13
SGTC_397 arbidol 50 µM -0.826901119994717 0.178851707473754 no 2754 0.204146554281324 3926 131410 A RNA synthesis inhibitor.
SGTC_2762 leflunomide 42.06 µM -0.826942343229368 0.178839205593423 no 2755 0.204134870943176 3842 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.826955886162995 0.178835098511861 no 2756 0.204131032741454 3858 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_901 1112-0062 60.1 µM -0.827452155697323 0.178684638875441 no 2757 0.203990414682591 3869 1908457
SGTC_3165 9101544 49.47 µM -0.828336734077609 0.178416648982023 no 2758 0.203739912414276 3882 5002184
SGTC_622 1348-1566 26.3 µM -0.829195151028145 0.178156827124005 no 2759 0.203496994180257 3929 7340407
SGTC_3267 9137951 49.47 µM -0.830246268240803 0.17783900459992 no 2760 0.203199780270627 3884 16643986
SGTC_2202 7226349 200 µM -0.830693125269071 0.17770399845335 no 2761 0.203073505506329 3826 844334
SGTC_1838 st055369 84.5 µM -0.830909456887328 0.177638662757772 no 2762 0.203012390430644 3866 676036
SGTC_2723 salbutamol 83.58 µM -0.833921213874936 0.176730637749807 no 2763 0.202162691056282 3865 9884233 β2-adrenoceptor agonist
SGTC_1863 st057641 20.1 µM -0.834707512732042 0.17649405770139 no 2764 0.201941205323399 3894 3921635
SGTC_2233 sulbentine 40.3845 µM -0.83508452302548 0.176380694671563 no 2765 0.201835060090792 3854 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_795 0685-0265 78 µM -0.836594552595184 0.175927106566246 no 2766 0.201410254307545 3922 302754
SGTC_1221 2958-7315 257 µM -0.837100647686531 0.175775249326893 no 2767 0.201267998188265 3904 4562705
SGTC_314 1671-0008 2.74 µM -0.838300478424939 0.175415563930973 no 2768 0.200930983637511 3800 3913060
SGTC_2812 7970281 58.44 µM -0.839372328415975 0.175094639499761 no 2769 0.200630203488818 3930 2233435
SGTC_2698 st077697 67.5 µM -0.842171438204695 0.174258310953833 no 2770 0.19984599932127 3858 3154499
SGTC_2689 tacrolimus 100 µM -0.842180581039569 0.174255583389129 no 2771 0.199843440870903 3912 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3355 9151058 44.0485 µM -0.843232258042171 0.173942019619659 no 2772 0.199549280319033 3880 17015728
SGTC_1583 clindamycin 39.6 µM -0.844143694664376 0.173670559749738 no 2773 0.199294556774878 3865 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2892 9047358 58.44 µM -0.844642446478502 0.173522126994207 no 2774 0.19915525115265 3887 6466771
SGTC_2067 5224629 34.075 µM -0.845621863630929 0.173230879193497 no 2775 0.198881862360824 3895 2835000
SGTC_1745 st081495 74 µM -0.846694755041139 0.172912192586967 no 2776 0.198582641475842 3816 13842402 YBL026W LSM2
SGTC_476 mead acid 10 µM -0.846935477843019 0.172840740766024 no 2777 0.198515543114856 3904 5312531 An omega 9 fatty acid.
SGTC_954 1189-0853 2.85 µM -0.847842068681681 0.172571813578789 no 2778 0.198262965440175 3853 2828194
SGTC_469 w7 172 µM -0.848121931337745 0.172488850254437 no 2779 0.19818503444963 3934 45115570 A P450 inhibitor.
SGTC_1128 3448-9350 235 µM -0.850805779666809 0.171694534191786 no 2780 0.197438625268849 3957 619386
SGTC_1303 1160-0052 261 µM -0.85219257684263 0.17128501257539 no 2781 0.197053607996388 3879 3562476
SGTC_883 0850-0245 24.6 µM -0.853778756007277 0.170817379678481 no 2782 0.196613793725206 4003 6823229 YPR165W RHO1
SGTC_1206 3978-0017 132 µM -0.8558492295149 0.170208198986058 no 2783 0.196040590372335 4022 3873677
SGTC_1868 st057644 42.7 µM -0.856992609625202 0.169872387735795 no 2784 0.195724484492576 3910 688665
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.85796922719964 0.169585891334163 no 2785 0.195454727954724 3894 15053
SGTC_1267 0828-0272 9.49 µM -0.858361192084087 0.169470993396707 no 2786 0.195346524861192 3986 745334
SGTC_1158 4092-0494 91.8 µM -0.859723755062939 0.169071969645391 no 2787 0.194970668440988 4012 1148199
SGTC_1628 st004252 77.7 µM -0.862207116866379 0.168346275587894 no 2788 0.194286777031843 3951 692968
SGTC_3003 9075612 71.4286 µM -0.862433998959859 0.168280075567201 no 2789 0.194224369026088 3949 6501993
SGTC_493 zm226600 134 µM -0.862932627489799 0.168134643785074 no 2790 0.194087255175867 3949 5240098 A potassium channel opener. YCR052W RSC6
SGTC_680 0417-1641 114 µM -0.863717034216453 0.167906024637506 no 2791 0.193871676862136 3882 2835990
SGTC_2173 5763948 167 µM -0.864485664552421 0.167682197802652 no 2792 0.193660576000598 3913 2867177
SGTC_1314 1222-0010 41.1 µM -0.866084497921685 0.167217229903016 no 2793 0.193221912852475 3924 3526027
SGTC_2838 9002687 71.43 µM -0.86939899301606 0.166255968560174 no 2794 0.192314466846395 3909 6457060
SGTC_2445 5742597 35.57 µM -0.870660501801201 0.165891048576187 no 2795 0.191969775522878 3899 1774255
SGTC_691 1548-0686 185 µM -0.872832046272965 0.165264093725004 no 2796 0.191377314807301 3951 46495133
SGTC_2098 5376439 882.5 nM -0.87396936647959 0.164936346348357 no 2797 0.191067468269583 3956 2844116
SGTC_1164 k060-0068 93.7 µM -0.874635328307293 0.164744628251699 no 2798 0.190886179437231 3925 5963676
SGTC_178 4092-0806 87.505 µM -0.877026345242629 0.16405748884204 no 2799 0.19023616431059 3864 2169044
SGTC_2877 9040724 71.43 µM -0.880071609624182 0.163185025245002 no 2800 0.189410258920639 3907 6463895
SGTC_3184 9108758 49.47 µM -0.880346750326411 0.163106346640017 no 2801 0.189335746936221 3960 902885
SGTC_2793 7325131 81.82 µM -0.881427853142575 0.162797435763548 no 2802 0.189043143813191 3924 4176441
SGTC_393 acivicin 6.25 µM -0.882228631991002 0.162568869214937 no 2803 0.188826590720164 3802 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2274 7947094 46.08 µM -0.88271062176336 0.162431395435089 no 2804 0.188696320874089 3900 2971028
SGTC_3243 9134147 49.47 µM -0.882936807553057 0.162366908506544 no 2805 0.188635207584345 3998 24282180
SGTC_2082 5219693 150 µM -0.88492670800831 0.161800294231377 no 2806 0.188098081076957 3931 2834649
SGTC_244 nsc-207895 1.295 µM -0.885280256984893 0.161699757877252 no 2807 0.18800274775511 3763 42640
SGTC_1694 st024011 44.9 µM -0.887603518475725 0.161040120643363 no 2808 0.187377030186526 3968 2787533
SGTC_416 estradiol valerate 100 µM -0.888082488328178 0.160904346702679 no 2809 0.187248190805229 3974 13791 A steroid.
SGTC_550 4123-0385 25.7 µM -0.889345433759598 0.160546697016064 no 2810 0.186908730466887 3970 5731123
SGTC_2071 5230951 39.92 µM -0.889525541157926 0.160495735289992 no 2811 0.186860351407942 3977 1799272
SGTC_2593 nobiletin 86.24 µM -0.890227029099865 0.160297348712913 no 2812 0.186671997012291 3984 72344 An anti-infammatory.
SGTC_2601 securinine 100 µM -0.891250608105255 0.160008159795221 no 2813 0.186397369897917 3919 442872 A GABA receptor antagonist.
SGTC_1302 1159-0335 255 µM -0.892103244866541 0.159767527338708 no 2814 0.186168797909141 3965 649284
SGTC_807 1315-0151 48 µM -0.892298682229971 0.159712404077219 no 2815 0.186116430202116 3972 4011080
SGTC_1300 1094-0077 113 µM -0.892424837798502 0.159676828410091 no 2816 0.186082631495784 3916 5532636
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.893119965718334 0.15948089646777 no 2817 0.185896465994864 3997 6708784 An antioxidant flavonoid
SGTC_815 1582-0027 36.9 µM -0.893542476631401 0.159361882539003 no 2818 0.185783367801846 4032 3128206
SGTC_3347 9188721 44.724 µM -0.894023717677581 0.159226396218511 no 2819 0.185654600664979 3993 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1294 1000-1494 117 µM -0.895155704019665 0.158907999678199 no 2820 0.185351930007864 3956 712797 YDL207W GLE1
SGTC_2774 tamoxifen 10.92 µM -0.895826159226251 0.158719616004662 no 2821 0.185172808148412 3974 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1982 st072467 71.9 µM -0.896012779040204 0.158667205859732 no 2822 0.185122969084831 3941 3163533
SGTC_1835 st008666 49.2 µM -0.896509132390845 0.158527865650554 no 2823 0.184990452515656 3902 690455
SGTC_3321 9137793 26.8275 µM -0.897252420354027 0.158319354138345 no 2824 0.184792119515573 3922 4904192
SGTC_710 3448-4187 58 µM -0.897363137478473 0.158288310524188 no 2825 0.184762587960305 3943 3946412
SGTC_1199 1638-0010 4.46 µM -0.898028836689309 0.158101741497882 no 2826 0.184585088005599 3951 3111136
SGTC_2086 5274770 176.623 µM -0.898725477895122 0.157906655284731 no 2827 0.184399451365821 4034 689278
SGTC_1942 st076330 65.2 µM -0.899695481708371 0.157635280462906 no 2828 0.184141164275753 3979 24208414
SGTC_47 0149-0135 24.25 µM -0.901494466191207 0.157132795974789 no 2829 0.183662737391977 4002 5239155
SGTC_1223 0764-0573 147 µM -0.903253268367459 0.156642554480532 no 2830 0.183195746189394 3961 1609797
SGTC_18 0111-0177 500 nM -0.903558377716708 0.156557612109219 no 2831 0.183114810032288 4016 721752
SGTC_2423 st077119 87.2 µM -0.903853149304902 0.156475576575512 no 2832 0.183036637354957 3898 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_854 0422-0053 192 µM -0.907057620882692 0.155585592320193 no 2833 0.182188163607751 3997 3596728
SGTC_14 0354-0009 295 µM -0.907119076626998 0.155568556790409 no 2834 0.182171915537604 4044 1713507
SGTC_2140 5586273 200 µM -0.908065119197678 0.155306469090931 no 2835 0.181921908936762 3949 854421
SGTC_2984 9022109 38.96 µM -0.910440604983824 0.154649659629419 no 2836 0.181295095918583 4009 6459207
SGTC_481 bay k-8644 50 µM -0.913765087403463 0.153733543958853 no 2837 0.180420147559795 3951 2303 A calcium channel antagonist.
SGTC_2589 lobaric acid 100 µM -0.914915057144303 0.153417488930101 no 2838 0.180118112385257 4005 73157 A novel microtubule depolymerizer.
SGTC_1414 3917-0015 5.4 µM -0.915126821487124 0.153359335067291 no 2839 0.180062527913754 3933 6618702
SGTC_681 1642-0006 26.6 µM -0.917491556871951 0.152710933185339 no 2840 0.179442557615417 4015 4446530
SGTC_1647 st011722 22.4 µM -0.918601384968849 0.152407250230676 no 2841 0.179152053654217 3961 2854783
SGTC_2467 5474540 200 µM -0.92094353137736 0.151767683566747 no 2842 0.178539954797105 3948 5413519
SGTC_3216 9129716 49.47 µM -0.922456043204367 0.151355613179621 no 2843 0.178145374282248 3970 8056934
SGTC_3171 9103192 49.47 µM -0.922992473103648 0.151209646537188 no 2844 0.178005563867121 4019 13018434
SGTC_2652 actinonin 100 µM -0.927583015037712 0.149964355696276 no 2845 0.176811955785359 3990 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_557 1315-0110 16.2 µM -0.928574407915598 0.149696317911567 no 2846 0.176554844935211 3981 6833801
SGTC_956 1185-0240 191 µM -0.930168456128147 0.149266013815391 no 2847 0.176141935646795 4001 1416193
SGTC_3304 9125678 46.087 µM -0.932616734795687 0.148606725031056 no 2848 0.175508944888496 3953 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_211 3455-0679 143.504 µM -0.933046984635277 0.148491065923191 no 2849 0.175397854976789 4056 748649
SGTC_3298 9116858 71.43 µM -0.934114911926021 0.148204247523081 no 2850 0.175122310321238 4081 2506942
SGTC_1286 0929-0070 131 µM -0.934353111748956 0.148140323636859 no 2851 0.17506088790919 4107 1420408
SGTC_1684 st024538 14.6195 µM -0.934877681940595 0.147999613761941 no 2852 0.174925669983669 4003 6732859
SGTC_1074 carmofur 3.8 µM -0.936919628497943 0.147452737345216 no 2853 0.17439995083856 4036 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2566 crystal violet carbinol 226 nM -0.937167335392023 0.147386488413079 no 2854 0.174336244606557 4076 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_776 4476-4378 112 µM -0.937420791918711 0.147318722396925 no 2855 0.174271074967519 4077 2892008
SGTC_3099 9120367 49.47 µM -0.938629810446862 0.146995757652354 no 2856 0.17396042092102 4026 24824940
SGTC_615 k087-0205 167 µM -0.939854370417161 0.146669125686017 no 2857 0.173646132702668 4004 9642773
SGTC_1067 clotrimazole 1.36 µM -0.941140937338765 0.14632647937512 no 2858 0.17331631958331 4035 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3070 9117005 49.47 µM -0.94204785671412 0.146085266343977 no 2859 0.1730840694357 4084 8779016
SGTC_2081 5214970 32.255 µM -0.942407593370591 0.145989661342947 no 2860 0.172992000538698 3949 2063512
SGTC_3083 9117465 49.47 µM -0.94277340125576 0.145892485947658 no 2861 0.172898409809173 4020 16420915
SGTC_1740 st038286 13.222 µM -0.944917212292295 0.1453238651212 no 2862 0.172350571686519 4087 716786
SGTC_419 nsc-638432 893 µM -0.945037756770437 0.14529193644164 no 2863 0.172319800183297 3996 368090
SGTC_3094 9117742 49.47 µM -0.945299582684923 0.145222602732761 no 2864 0.172252975709091 3954 17149698
SGTC_1004 4084-0029 199 µM -0.949420964791206 0.1441341593019 no 2865 0.171203275907638 4055 716894 YLR208W SEC13
SGTC_90 0870-0863 4.608 µM -0.952470518765055 0.143332331796564 no 2866 0.170429205257529 4040 1738164
SGTC_2109 5483026 200 µM -0.952790886303296 0.143248271871611 no 2867 0.17034801642296 4045 759335
SGTC_803 4488-1585 147 µM -0.953937963043633 0.142947568181233 no 2868 0.17005752280153 4036 747204
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.955268158495688 0.142599394822316 no 2869 0.169721052756704 4071 23665772 A membrane-active detergent.
SGTC_1633 st005664 67.9 µM -0.955537966131968 0.14252884376159 no 2870 0.169652857623092 4034 2063822
SGTC_2937 9044753 11.33 µM -0.9556133498616 0.142509136152139 no 2871 0.169633807177117 4000 6465530 YGL099W LSG1
SGTC_304 1310-0298 97 µM -0.956932282823855 0.142164624993537 no 2872 0.169300717772024 3880 1550234
SGTC_2090 5301565 104.445 µM -0.957647342324574 0.141978084085337 no 2873 0.169120308982401 4039 2056344
SGTC_1473 k844-0725 134 µM -0.959036029790231 0.141616284293409 no 2874 0.168770297354211 4094 54682906
SGTC_2391 6285546 200 µM -0.960242192274963 0.141302545670743 no 2875 0.168466668236581 4027 846083
SGTC_2537 larixol 68.93 µM -0.961102709017106 0.141079002208373 no 2876 0.168250263862987 4036 6708759
SGTC_678 1218-2179 85.9 µM -0.962898124949688 0.140613364901585 no 2877 0.1677993253267 4023 6820081 YOR116C RPO31
SGTC_2349 9023730 187.07 µM -0.963926329085385 0.140347172607103 no 2878 0.167541431260126 4076 4126287
SGTC_2224 6650123 117.647 µM -0.965321965339204 0.139986403427359 no 2879 0.167191786637521 4011 2908370
SGTC_2696 st077691 74.316 µM -0.965754756061237 0.139874656015587 no 2880 0.167083456478326 4112 757133
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.966418894003891 0.139703292234705 no 2881 0.166917306733053 4059 7104
SGTC_1782 st039423 80.636 µM -0.967202435467262 0.139501303044008 no 2882 0.166721422465043 4076 2068169
SGTC_765 1319-0117 244 µM -0.970540695065865 0.138642959533437 no 2883 0.165888525240007 4008 3487746 YGL099W LSG1
SGTC_3016 9080866 49.47 µM -0.971144221188216 0.138488163903697 no 2884 0.165738232761692 4039 17066299
SGTC_1897 st060201 15 µM -0.971594263249136 0.138372811375304 no 2885 0.165626218812369 4105 611878
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.971911491342925 0.138291540418934 no 2886 0.165547291234736 4100 91467 include heat shock
SGTC_3156 9099931 49.47 µM -0.977382217304977 0.13689510851453 no 2887 0.164189981663892 4077 18111053
SGTC_119 0121-0043 24.815 µM -0.977399975845519 0.136890591301604 no 2888 0.164185587482098 4070 1092378
SGTC_1415 3966-0071 78.1 µM -0.978001509583047 0.136737640248678 no 2889 0.164036788732695 3994 2893185
SGTC_2560 caryophyllene 100 µM -0.978269519959325 0.136669531302996 no 2890 0.16397052036854 4095 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_724 3910-0327 137 µM -0.980119427729559 0.136200050553434 no 2891 0.16351358515552 4127 2885483
SGTC_3023 9089636 49.47 µM -0.980269690940853 0.136161964372852 no 2892 0.163476505840112 4128 17249241
SGTC_253 dyclonine 31.25 µM -0.980497716460563 0.136104182240008 no 2893 0.163420248140443 4161 3180 An oral anasthetic.
SGTC_2072 5231554 129 µM -0.980575186854864 0.136084554903938 no 2894 0.163401137764042 4101 789545
SGTC_1933 st074711 15.9 µM -0.980715975108797 0.136048890775001 no 2895 0.163366411871013 4034 17250958
SGTC_2041 5107442 45.335 µM -0.983724435583255 0.135288323988749 no 2896 0.162625510922064 4118 793005
SGTC_2001 4023502 57.655 µM -0.983899512744109 0.135244152775725 no 2897 0.16258246165255 4110 108941 YCR052W RSC6
SGTC_277 nystatin 15.5 µM -0.984828660773898 0.135009898208021 no 2898 0.162354119948887 4063 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1829 berberine 14.4 µM -0.985268331680648 0.134899146489898 no 2899 0.162246141927098 4070 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3053 9095903 49.47 µM -0.985464214558272 0.134849824283438 no 2900 0.162198050446729 4162 17174018
SGTC_857 0438-0306 1.35 µM -0.985991734775792 0.134717059188164 no 2901 0.162068584376855 4135 4686136
SGTC_899 1083-0020 478 µM -0.987883928535685 0.134241574201747 no 2902 0.161604748639324 4147 767123
SGTC_385 1494-0393 12.4 µM -0.988261813254458 0.134146754676972 no 2903 0.161512221070647 4071 3090647
SGTC_166 k072-0058 166.424 µM -0.988586624830714 0.134065289139359 no 2904 0.161432716421711 3996 5846229
SGTC_1921 5740136 50 µM -0.989006344732635 0.133960070125318 no 2905 0.161330018712496 4019 1774243
SGTC_2381 9035592 200 µM -0.989240785629035 0.133901323161639 no 2906 0.161272673906751 4071 4749657
SGTC_2844 9010103 25.97 µM -0.991556766153722 0.133321928588876 no 2907 0.160706894068312 4111 2480525
SGTC_2259 7964009 200 µM -0.993847826408144 0.132750467769151 no 2908 0.160148479007925 4131 313134
SGTC_1281 0884-0031 11.8 µM -0.994676821887569 0.132544107076181 no 2909 0.159946735448332 4104 1548255
SGTC_677 0929-0063 136 µM -0.996181174203157 0.13217019542291 no 2910 0.159581062353658 4054 1539583
SGTC_2996 9066192 71.4286 µM -0.996546819531565 0.132079423059173 no 2911 0.15949226519298 4126 6472854
SGTC_2122 5258151 111.688 µM -0.996802657573733 0.13201593619538 no 2912 0.159430154025956 4076 2173356
SGTC_2775 cyproheptadine 69.59 µM -0.997103352489357 0.131941344891586 no 2913 0.159357172962627 4082 2913 A selective serotonin reuptake inhibitor.
SGTC_2992 9074591 71.4286 µM -0.997125798724934 0.131935777975692 no 2914 0.159351725959088 4039 17741321
SGTC_880 0833-0487 87.2 µM -0.998529559108138 0.131587951646133 no 2915 0.159011319173446 4081 76075
SGTC_2267 7931562 200 µM -0.998975135112273 0.131477678451131 no 2916 0.15890336830759 4013 934880
SGTC_499 genistein 192 µM -0.999348973579612 0.131385208418508 no 2917 0.158812834543955 4135 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_379 3970-0972 5.9 µM -0.999427500865449 0.131365790174029 no 2918 0.158793821615418 4082 2898042 YBL034C STU1
SGTC_2731 amoxapine 43.43 µM -0.999440063046696 0.131362683978958 no 2919 0.158790780214198 4191 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2925 9010536 32.5 µM -1.00133096571443 0.13089570706545 no 2920 0.15833341351507 4036 2994177
SGTC_665 3914-0008 307 µM -1.00151506590706 0.130850303081611 no 2921 0.158288930048914 4029 1069549
SGTC_867 0518-0118 155 µM -1.00259355001292 0.13058453899189 no 2922 0.158028504563083 4065 6848158
SGTC_1380 2291-0730 164 µM -1.00304880128848 0.130472466373419 no 2923 0.157918657854871 4130 2999191
SGTC_2710 st078562 53.7235 µM -1.00309672624539 0.130460672198761 no 2924 0.157907097051324 4041 17250908
SGTC_3233 9132340 49.47 µM -1.00459650067142 0.130091955190809 no 2925 0.157545591481515 4091 17682950
SGTC_2539 epi(13)torulosol 80 µM -1.0065465548231 0.12961361708154 no 2926 0.157076364396469 4135 6708597
SGTC_1076 itraconazole 331 nM -1.00989791629693 0.128794394512674 no 2927 0.156272100545059 4094 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.01014294416483 0.128734639975645 no 2928 0.156213405061506 4088 5106787 A p450 inhibitor.
SGTC_929 2805-0021 398 µM -1.01614164339577 0.127277744237284 no 2929 0.154780970476537 4176 3098024
SGTC_1484 3473-2379 286 µM -1.0167950716357 0.127119742529662 no 2930 0.154625463557712 4215 671917
SGTC_101 0490-5701 117.494 µM -1.01964435008483 0.126432370338464 no 2931 0.153948581628405 3896 4661669
SGTC_1093 fluphenazine 7.97 µM -1.02170145239121 0.125937718594438 no 2932 0.153461111744153 4117 6602611 An atypical antipsychotic.
SGTC_1163 k060-0048 49.9 µM -1.02255992151124 0.125731690356662 no 2933 0.153257983686186 4102 6809982
SGTC_861 0443-0273 110 µM -1.02427324223972 0.125321205256661 no 2934 0.152853116355294 4107 6149169
SGTC_1852 st056254 31.4 µM -1.02502963480111 0.125140283333849 no 2935 0.152674602416747 4037 442583
SGTC_1438 4092-1045 4 µM -1.02715941508402 0.124631840236111 no 2936 0.152172702570886 4115 1351342
SGTC_789 1309-1135 70.6 µM -1.0279090794929 0.124453216681133 no 2937 0.151996299102579 4103 3092424
SGTC_2321 7390090 138.78 µM -1.02862020945484 0.124283940290661 no 2938 0.151829088756181 4167 649046
SGTC_1565 sinapyl alcohol 95.1 µM -1.02881375881133 0.124237895962905 no 2939 0.151783600021657 4163 5280507 A phenol propionate derived from cinnamic acid.
SGTC_627 1391-0720 175 µM -1.02946047000787 0.124084133472534 no 2940 0.151631673090477 4106 997839
SGTC_2558 carylophyllene oxide 100 µM -1.03332298729156 0.123168551274596 no 2941 0.150726386603854 4245 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2401 5128683 200 µM -1.03390476138429 0.123031057218384 no 2942 0.150590344440451 4123 708373
SGTC_2688 kanamycin b 96.69 µM -1.03737190794737 0.122213877649165 no 2943 0.149781282610671 4185 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1358 1509-0022 2.48 µM -1.03898905067822 0.121834035656117 no 2944 0.149404914287781 4160 3258434
SGTC_1021 4476-0760 85.3 µM -1.03931103749061 0.121758505013072 no 2945 0.14933005159674 4124 746768
SGTC_1554 st069299 38.7 µM -1.03973051871189 0.12166015380145 no 2946 0.149232558799218 4115 24207999
SGTC_2291 7917025 104.35 µM -1.03977097989125 0.121650670260683 no 2947 0.149223157352002 4053 2964612
SGTC_2979 9012552 45.46 µM -1.03982139909741 0.121638853423236 no 2948 0.149211442638851 4157 17100905
SGTC_91 0417-1751 58.384 µM -1.03997408086912 0.121603074049889 no 2949 0.149175971348601 4252 6795624
SGTC_3121 9125696 49.47 µM -1.0416697588361 0.12120620687462 no 2950 0.148782407126183 4227 1235365
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.04391381732471 0.120682395032362 no 2951 0.148262632420579 4124 2724 A muscle relaxant with antifungal properties.
SGTC_864 0469-0573 172 µM -1.04595953686154 0.120206270194421 no 2952 0.147789857220416 4124 689425
SGTC_2168 5727979 200 µM -1.04661142990673 0.120054825760439 no 2953 0.147639414063271 4031 695210
SGTC_1594 piperine 70.1 µM -1.04783017774847 0.119772053356016 no 2954 0.147358428014886 4116 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2367 9070478 135.38 µM -1.04804560285777 0.119722119565798 no 2955 0.147308798392326 4095 572802
SGTC_523 1934-0222 13.7 µM -1.04941191214898 0.119405761991311 no 2956 0.146994289010461 4096 1361595
SGTC_1657 st012939 43.4 µM -1.04991106913832 0.119290333573361 no 2957 0.146879500947241 4169 24207257
SGTC_1960 st011366 51.8 µM -1.05751540489207 0.117541587890323 no 2958 0.145138213906851 4154 3972846
SGTC_2300 7976697 71.57 µM -1.05790387559809 0.117452742309061 no 2959 0.145049634058174 4042 2236109
SGTC_2482 5981709 142.65 µM -1.06179876256557 0.116564586025053 no 2960 0.144163525850747 4100 877755
SGTC_1479 0549-0158 134 µM -1.06233165390784 0.116443441501195 no 2961 0.144042574578263 4201 5440202
SGTC_2880 9042983 58.44 µM -1.06261281301445 0.116379560372937 no 2962 0.143978786993924 4149 6464714
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.06348333007147 0.116181931058221 no 2963 0.143781410464134 4194 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1777 st045864 34.765 µM -1.06905912716166 0.114921732029678 no 2964 0.142521513729914 4148 4691462
SGTC_703 3875-0075 71.8 µM -1.06957809574323 0.1148049352066 no 2965 0.142404629533916 4211 2850814
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.07152258316066 0.114368068327259 no 2966 0.14196726100387 4173 4620898
SGTC_392 N-ethylmaleimide 8.33 µM -1.07205203724222 0.114249321460631 no 2967 0.141848329956624 4100 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3020 9089140 49.47 µM -1.07326881206131 0.113976753943555 no 2968 0.141575262098421 4193 17217859
SGTC_2131 toluylene red 5.2905 µM -1.07418817240755 0.113771117201606 no 2969 0.141369176174742 4141 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2945 9067681 61.76 µM -1.07566676867556 0.11344094895504 no 2970 0.141038157300176 4240 16456930
SGTC_1771 st048882 4.1505 µM -1.07930659683503 0.112631093928893 no 2971 0.140225536540478 4198 4580403
SGTC_2881 9058953 51.95 µM -1.07990102119124 0.112499228815319 no 2972 0.140093129244746 4122 17122249
SGTC_2947 9072639 7.68 µM -1.08087119183408 0.112284246350909 no 2973 0.139877207428516 4177 16488146
SGTC_1227 3909-8010 46.6 µM -1.08160846777701 0.112121068029165 no 2974 0.139713270147525 4153 15982272
SGTC_2240 6690706 185.951 µM -1.08224805571285 0.11197964797185 no 2975 0.139571160175795 4039 805876
SGTC_2134 5324836 1.464 µM -1.08403025078322 0.11158625762847 no 2976 0.139175693175335 4131 699272
SGTC_2714 st079313 56.9 µM -1.08459890905533 0.111460943977119 no 2977 0.139049669209676 4154 2939799
SGTC_2513 baicalein 25.65 µM -1.08610531823267 0.111129467619842 no 2978 0.138716199862743 4190 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_153 4077-0274 519.67 µM -1.08659186707557 0.111022556417575 no 2979 0.138608610462806 4194 3121976
SGTC_1274 0865-0114 173 µM -1.0871585146486 0.110898137699231 no 2980 0.138483380697168 4179 870624
SGTC_2062 5245942 200 µM -1.08760682917472 0.110799772147699 no 2981 0.13838435731715 4227 1376160
SGTC_707 0865-0008 204 µM -1.0891547901595 0.110460611668481 no 2982 0.138042815903329 4190 723043
SGTC_40 0327-0103 19.753 µM -1.08961648287466 0.110359598382683 no 2983 0.137941059628957 4035 409036
SGTC_507 nimesulide 162 µM -1.09036452377766 0.110196075893406 no 2984 0.137776301340379 4256 4495 A COX2 inhibitor.
SGTC_2664 lyso-paf C-16 73.48 µM -1.0922377682922 0.109787345475458 no 2985 0.137364302868641 4152 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_89 0302-0250 142.109 µM -1.09311852082 0.10959554724825 no 2986 0.137170882596642 4288 4203518 YLR208W SEC13
SGTC_3072 9116419 49.47 µM -1.09325389637875 0.109566088357396 no 2987 0.137141169549225 4231 17170162
SGTC_1992 st073643 23.3 µM -1.09344274357069 0.109525003076263 no 2988 0.1370997275694 4156 3161292
SGTC_2087 5276107 200 µM -1.09374519956143 0.109459224304737 no 2989 0.137033372287654 4150 144405
SGTC_2339 9000433 200 µM -1.09732839692242 0.108682101305576 no 2990 0.136248930839002 4216 2988954
SGTC_149 3970-0822 46.1 µM -1.09899662881089 0.108321652424808 no 2991 0.135884768179908 4193 3114250 YBL034C STU1
SGTC_1002 4049-0206 172 µM -1.09962278849796 0.108186582644915 no 2992 0.135748254342538 4155 4662749
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.10252793898326 0.107561494618912 no 2993 0.135116109510018 4155 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_837 0091-0265 12.5 µM -1.10263914965453 0.107537617753628 no 2994 0.135091950858117 4142 759367
SGTC_1911 st060208 74.3 µM -1.10430362003923 0.107180713244205 no 2995 0.134730726517353 4233 688783
SGTC_62 0180-0423 3.232 µM -1.10449675423262 0.107139355762961 no 2996 0.134688855376368 4161 30102 YGL099W LSG1
SGTC_3008 9078912 71.4286 µM -1.10485906571634 0.107061801944885 no 2997 0.134610330998732 4190 16648731
SGTC_1769 st044406 64.4 µM -1.10689906583294 0.106625889769561 no 2998 0.134168784914611 4171 670903
SGTC_2222 6885208 172.143 µM -1.10723426776179 0.106554385727643 no 2999 0.134096327696807 4160 609514
SGTC_1152 3909-8331 15.9 µM -1.10775303991131 0.106443791413592 no 3000 0.133984242962543 4159 16001939
SGTC_636 0kpi-0074 126 µM -1.10826492077186 0.106334747476506 no 3001 0.133873710260557 4203 616434
SGTC_139 0099-0334 718.624 µM -1.10861462360895 0.106260298073078 no 3002 0.133798233420074 4239 97690
SGTC_2450 5739737 12.93 µM -1.11020174713942 0.105922883209603 no 3003 0.133456050041981 4228 2262825
SGTC_124 0136-0217 7.121 µM -1.11143797692815 0.10566060362323 no 3004 0.133189936615643 4254 3976905
SGTC_2822 7994718 71.43 µM -1.11259773378683 0.105414975787872 no 3005 0.132940617096746 4172 1018011
SGTC_597 k018-0003 82.8 µM -1.1126867907829 0.105396131271781 no 3006 0.132921485301282 4276 6786234
SGTC_1232 0279-0259 161 µM -1.11373711882302 0.105174065024446 no 3007 0.132695990103431 4208 1560000
SGTC_268 camptothecin 39.6153 µM -1.12357131937101 0.10311127320752 no 3008 0.130597464486573 4196 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2980 9014342 25.29 µM -1.12369918716268 0.103084646952089 no 3009 0.130570330685347 4280 2996599
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.1262797216402 0.102548362224838 no 3010 0.130023569169051 4157 97141
SGTC_2600 tangeritin 87.95 µM -1.12765984326515 0.102262380209474 no 3011 0.129731801465103 4159 68077 A bioactive flavone.
SGTC_120 rhodamine 6G 52.259 µM -1.1288965245018 0.102006614377548 no 3012 0.12947074354401 4230 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1103 duloxetine 36.1 µM -1.13088267198373 0.101596821355679 no 3013 0.129052238742586 4294 60835 A selective serotonin reuptake inhibitor.
SGTC_583 1488-1091 88.9 µM -1.13144835100096 0.101480326946004 no 3014 0.128933215287734 4331 4303273
SGTC_900 1112-0045 141 µM -1.1315909390995 0.101450978096414 no 3015 0.12890322561268 4095 56211 YIL048W NEO1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.13489419450182 0.100772800119216 no 3016 0.128209826339421 4211 364106
SGTC_3037 9091026 49.47 µM -1.13633617378292 0.100477792044769 no 3017 0.127907948473458 4150 25236398 YIL048W NEO1
SGTC_3336 9143619 71.43 µM -1.14098630793495 0.0995307351929926 no 3018 0.1269378104328 4270 45595730
SGTC_2782 7736369 71.43 µM -1.14141441326448 0.0994438753460316 no 3019 0.126848754769914 4252 2950836 YOL077C BRX1
SGTC_1870 st057514 26.5 µM -1.1436199222255 0.098997269516249 no 3020 0.126390647957428 4230 5393161
SGTC_1520 flindersine 88 µM -1.14788098581265 0.0981385819275958 no 3021 0.125508849319389 4310 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1237 0330-0133 46.1 µM -1.14926198068882 0.0978614586829265 no 3022 0.12522398508128 4181 X1237 YHR072W ERG7
SGTC_755 1995-0008 37.3 µM -1.14987124507072 0.0977393805500345 no 3023 0.125098452909925 4212 689533
SGTC_1444 4112-3581 28 µM -1.1510971755351 0.0974940796144857 no 3024 0.124846129931981 4295 2877249
SGTC_1150 3909-7983 10.9 µM -1.15148309065096 0.0974169539610179 no 3025 0.124766773903155 4215 23965914
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.15197950008565 0.0973178116928982 no 3026 0.124664748682796 4373 16725076
SGTC_909 3448-9333 149 µM -1.15448079148383 0.0968193829853673 no 3027 0.124151554598804 4164 3344074
SGTC_1983 st071813 46.9 µM -1.15569847472459 0.0965774165203668 no 3028 0.123902256140457 4298 11838595
SGTC_825 1988-2224 89.6 µM -1.15939130628134 0.0958463288745289 no 3029 0.123148359425742 4234 1180859
SGTC_3223 9129970 49.47 µM -1.16381015365248 0.0949768682137905 no 3030 0.122250478205265 4262 17248386
SGTC_15 0266-0086 27.098 µM -1.1645056550937 0.0948405509569561 no 3031 0.122109576468598 4314 1712902 YIL048W NEO1
SGTC_3274 9138298 49.47 µM -1.16538719066068 0.0946679785192117 no 3032 0.121931149970056 4240 17015756
SGTC_2357 9067248 200 µM -1.16575237677417 0.0945965562677571 no 3033 0.121857288439469 4240 9150235
SGTC_1530 rhein 70.4 µM -1.16642196587197 0.0944657027870561 no 3034 0.121721940869078 4317 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1366 1683-0113 21.9 µM -1.16665068143268 0.0944210369726047 no 3035 0.121675733600745 4256 708623
SGTC_307 1501-1223 22.3 µM -1.16715773824518 0.0943220694886712 no 3036 0.121573337175043 4285 2830329
SGTC_237 nikkomycin 200 µM -1.16785544919254 0.0941860151688681 no 3037 0.121432538567731 4260 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_350 k064-0020 19.8 µM -1.16915641600967 0.093932712099183 no 3038 0.121170308718102 4287 2790705
SGTC_1512 0259-0544 12.2 µM -1.17445112999917 0.0929069975346192 no 3039 0.120107187822136 4238 18476
SGTC_1001 4048-4355 44.4 µM -1.17520391379318 0.0927618400037983 no 3040 0.119956572404767 4240 21824233
SGTC_2354 9060492 162 µM -1.17963912927452 0.0919100114618345 no 3041 0.11907188661349 4293 6471895
SGTC_246 cycloheximide 667 µM -1.17978503250659 0.0918820880058838 no 3042 0.11904286198354 4163 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.17992158855827 0.0918559591378718 no 3043 0.119015701320486 4276 16486 A toxic proline analog.
SGTC_3057 9095946 49.47 µM -1.18047094605751 0.0917508997400743 no 3044 0.118906479674256 4303 24540043
SGTC_976 1348-1067 47.6 µM -1.18243558795169 0.0913759090615643 no 3045 0.118516454656583 4271 5310671 YGL099W LSG1
SGTC_1785 bathophenanthroline 24 µM -1.18412149576958 0.0910550270686342 no 3046 0.118182486074678 4194 72812 An iron chelator.
SGTC_3097 9117246 49.47 µM -1.18518261222686 0.0908534918051244 no 3047 0.117972626600613 4281 16423892
SGTC_20 0481-0013 4.944 µM -1.185248892127 0.0908409144160729 no 3048 0.117959527023304 4319 182045
SGTC_447 ml7 120 µM -1.18565857884823 0.0907632002233679 no 3049 0.117878579266957 4317 4216 Selective myosin light chain kinase inhibitor.
SGTC_1431 4049-0260 9.09 µM -1.1890965857838 0.0901129819746881 no 3050 0.117200830878614 4278 3854841
SGTC_1485 3909-9022 254 µM -1.19139490165718 0.0896802435732877 no 3051 0.11674929673256 4339 714516
SGTC_1850 st056238 17 µM -1.19434416193951 0.08912720793996 no 3052 0.116171684696007 4299 5393177
SGTC_3211 9128781 49.47 µM -1.19516140241572 0.0889744117025378 no 3053 0.116011987776545 4259 17194361
SGTC_2253 7938677 135.83 µM -1.19788957945554 0.0884657471443268 no 3054 0.115480003523379 4340 2301972
SGTC_3268 9137683 49.47 µM -1.20428875025966 0.087281137463021 no 3055 0.114238996642119 4362 1953228
SGTC_2376 9072922 81.32 µM -1.20432637440921 0.0872742077019655 no 3056 0.11423172829264 4296 17087968
SGTC_215 1287-0124 461.5 µM -1.20813205953457 0.0865753822102214 no 3057 0.11349823489766 4303 5560863
SGTC_1865 st057639 52.2 µM -1.20989610220197 0.0862528791932703 no 3058 0.113159381544604 4284 688818
SGTC_463 ikarugamyin 104 µM -1.21202408962172 0.0858650363800534 no 3059 0.112751579726468 4438 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2484 5809818 12.04 µM -1.21238009833163 0.0858002785785839 no 3060 0.112683457761059 4253 2870548
SGTC_1629 st005085 44.9 µM -1.21763825935922 0.0848480747652696 no 3061 0.111680734345093 4243 24207091
SGTC_363 0455-0021 3.06 µM -1.22069280341813 0.0842985756857668 no 3062 0.11110117679042 4267 4597466
SGTC_250 brefeldin a 552.239 µM -1.22525079273525 0.083483585527074 no 3063 0.110240371140937 4196 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2465 5809242 33.21 µM -1.22725286789547 0.0831274824364432 no 3064 0.109863782189933 4355 2731748
SGTC_2849 9019321 12.99 µM -1.22920086252369 0.0827820960619017 no 3065 0.109498252810443 4332 16489627
SGTC_3307 9126885 69.2785 µM -1.22937877100663 0.082750606146938 no 3066 0.109464912939114 4271 24824909
SGTC_2868 9035608 32.47 µM -1.23312688855882 0.0820892805344258 no 3067 0.108764213517281 4291 6462614
SGTC_999 SEC7.066 22.7 µM -1.23366440175367 0.081994767955229 no 3068 0.108663992053754 4274 740511 YDR170C SEC7
SGTC_1016 4226-1401 38 µM -1.23543878534816 0.081683354735268 no 3069 0.108333622764254 4300 2901613
SGTC_1446 4239-0190 62 µM -1.23830970487214 0.0811813836261482 no 3070 0.107800623337464 4338 1340085
SGTC_2031 5180455 200 µM -1.23887781026597 0.0810823286647291 no 3071 0.107695376209983 4301 29949
SGTC_1409 3909-8004 61.9 µM -1.24031859856845 0.0808315215793648 no 3072 0.107428787959765 4359 2119279
SGTC_1418 3966-3099 2.4 µM -1.24305320526886 0.0803571029360427 no 3073 0.106924113999163 4326 740335
SGTC_1495 4469-0029 237 µM -1.24712624676346 0.0796543882242192 no 3074 0.106175605222431 4337 793680
SGTC_2446 5162541 200 µM -1.24772277603998 0.0795518615855876 no 3075 0.106066298724914 4285 1549321
SGTC_3031 9088762 49.47 µM -1.248722529427 0.0793802560033992 no 3076 0.105883288828484 4293 205253
SGTC_1297 1068-0111 14.1 µM -1.25019148149011 0.0791286219470654 no 3077 0.105614803933234 4321 767057
SGTC_1301 naphtanilide LB 4.81 µM -1.25159343042296 0.0788890294218906 no 3078 0.105359024831715 4384 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1581 himbacine 57.9 µM -1.25665095173288 0.0780292671891103 no 3079 0.104440028045984 4337 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_832 4083-0019 164 µM -1.25763004853736 0.0778636483324532 no 3080 0.104262790501853 4420 1990758
SGTC_460 trequinsin 123 µM -1.25892171612425 0.0776455649480348 no 3081 0.104029304582003 4417 5537 A vasodilator.
SGTC_2120 5538279 151.968 µM -1.26556258588145 0.0765316446458063 no 3082 0.102834864081315 4300 2058197
SGTC_771 0250-0039 27.3 µM -1.26833305596796 0.0760705438020276 no 3083 0.102339518550568 4305 3005115
SGTC_407 eburnamonine 100 µM -1.26845142788518 0.0760508898876407 no 3084 0.102318392993645 4183 3195
SGTC_997 3996-0078 137 µM -1.27653953542078 0.074717114745252 no 3085 0.100882430205716 4388 735687
SGTC_3138 9097216 49.47 µM -1.28032175885899 0.0740995629214355 no 3086 0.100215999136661 4288 25237486
SGTC_3299 9121982 43.1275 µM -1.28075475750416 0.0740291134751783 no 3087 0.100139909889542 4371 17594604 YPL160W CDC60
SGTC_122 0236-0016 402.397 µM -1.28101975044441 0.0739860240252271 no 3088 0.100093364471172 4344 6808838
SGTC_1945 st075991 56.6 µM -1.28297127999712 0.0736692835598676 no 3089 0.099751069091182 4326 1084980
SGTC_524 r073-0010 27.8 µM -1.28456190747813 0.0734118864832572 no 3090 0.0994727085842751 4277 2772106
SGTC_2993 9054257 71.4286 µM -1.28796765248968 0.0728630787915189 no 3091 0.0988786118045521 4272 6470217 YGL055W OLE1
SGTC_3309 9129340 25.759 µM -1.29543932966297 0.0716700894081019 no 3092 0.0975843589757424 4373 17158987
SGTC_2759 disulfiram 3.38 µM -1.30843522173007 0.0696308340610837 no 3093 0.0953628663239185 4285 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1165 k072-0275 30.3 µM -1.30891737378465 0.0695560454480156 no 3094 0.0952811703944455 4342 6153523 YGL055W OLE1
SGTC_1393 3470-5649 58.2 µM -1.30944949184313 0.0694735782161568 no 3095 0.0951910680464652 4355 4108395
SGTC_2635 hydroquinidine 100 µM -1.311635525198 0.0691355783876506 no 3096 0.0948215702771363 4302 442912 An experimental heart treatment.
SGTC_330 1488-0319 80.1 µM -1.31485600411904 0.0686399450465063 no 3097 0.0942791506501288 4410 6846614
SGTC_1704 st028805 70.8 µM -1.31563683113254 0.0685201891228635 no 3098 0.0941479827021784 4409 2876101
SGTC_3089 9117425 49.47 µM -1.31787892938489 0.0681772129214976 no 3099 0.0937720901304435 4358 9401657
SGTC_165 k038-0023 64.381 µM -1.31814103922804 0.0681372043571603 no 3100 0.0937282192855469 4369 46368543
SGTC_1622 st003707 19.4 µM -1.31844213357511 0.0680912675503706 no 3101 0.0936778420812401 4392 10140899
SGTC_1864 st057645 30.4 µM -1.31977531510157 0.0678881564121793 no 3102 0.093455022788146 4417 688666
SGTC_1705 st027868 56.3335 µM -1.32195248001302 0.067557470161431 no 3103 0.093091987622002 4313 292948
SGTC_3046 9092212 49.47 µM -1.3234835733286 0.0673256611534495 no 3104 0.0928373077390632 4456 25236637
SGTC_1052 3253-3998 198 µM -1.32414709753382 0.0672253941167241 no 3105 0.0927270982177094 4317 5450317
SGTC_1957 st077035 62.4 µM -1.32671218560852 0.0668388619067684 no 3106 0.0923019542321844 4391 705593
SGTC_340 k038-0059 454 µM -1.32809866613094 0.0666306507487974 no 3107 0.0920727570335386 4347 23733424
SGTC_3339 9145883 14.936 µM -1.33307065483925 0.0658881210680721 no 3108 0.0912543091901465 4306 2030670
SGTC_1626 st003712 1.76 µM -1.33611969034586 0.0654359522658909 no 3109 0.0907550775362588 4419 24207035
SGTC_2133 5320837 200 µM -1.33831637340426 0.0651116807485066 no 3110 0.0903966633029558 4412 2841355
SGTC_2713 st079149 53.4 µM -1.34270525608976 0.0644675357974354 no 3111 0.0896837160459506 4434 3103253
SGTC_1137 ixabepilone 100 µM -1.34614190624031 0.0639666124895767 no 3112 0.0891283780312587 4345 154225 A novel microtubule stabilizer.
SGTC_3240 9133527 49.47 µM -1.34819527103269 0.0636687633454833 no 3113 0.0887977926070372 4361 17617455
SGTC_1329 1447-1697 50.6 µM -1.3537951217592 0.0628619646156751 no 3114 0.087900875223241 4406 2840515
SGTC_2956 9076196 2.52 µM -1.35726008501755 0.0623667532479302 no 3115 0.0873492925950834 4402 16423868
SGTC_2005 4024620 188 µM -1.36234197685753 0.0616459604157691 no 3116 0.0865449929929309 4365 236743
SGTC_1374 2889-5571 141 µM -1.36293918731106 0.0615616836162318 no 3117 0.0864508385568356 4420 2853281
SGTC_308 4092-1169 104 µM -1.36480778804954 0.0612985726057343 no 3118 0.0861567351856247 4371 2268590 YDL196W YDL196W
SGTC_526 4469-0568 170 µM -1.36678407056175 0.0610212561606981 no 3119 0.0858464985995692 4366 2901964
SGTC_3051 9093778 49.47 µM -1.36749213737741 0.0609221375868337 no 3120 0.085735550041959 4496 17217378
SGTC_741 4582-0002 126 µM -1.37382255108685 0.0600415603887133 no 3121 0.0847483891608088 4436 2912688
SGTC_3350 9150499 3.57 µM -1.37506810273239 0.0598694801117012 no 3122 0.0845551660867709 4419 4910996 YPR165W RHO1
SGTC_698 k064-0052 127 µM -1.37960453386358 0.0592460093968788 no 3123 0.0838542203634135 4504 5088751
SGTC_1082 camptothecin 424.86 nM -1.38226814218818 0.0588823119848289 no 3124 0.0834446920076954 4299 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1862 st057513 3.81 µM -1.38422534946646 0.0586161871394023 no 3125 0.0831447318342125 4410 5393163
SGTC_2464 5717415 7.67 µM -1.38437944992769 0.0585952739983436 no 3126 0.0831211489869661 4385 5285744
SGTC_2818 7996756 12.99 µM -1.38727838640382 0.058202946795467 no 3127 0.0826784455469451 4440 2241621
SGTC_2427 5545055 42.75 µM -1.39024443212055 0.0578036763378133 no 3128 0.0822273326574637 4352 5372858
SGTC_1526 st051518 75 µM -1.39066732535731 0.0577469249238715 no 3129 0.0821631651190768 4423 673993
SGTC_2016 5121758 140 µM -1.39125407233111 0.0576682572420563 no 3130 0.0820741977801095 4362 2795203
SGTC_2294 7971431 200 µM -1.39478557680387 0.0571965519938051 no 3131 0.0815402547782949 4416 5741572
SGTC_2091 4-phenylthiadiazole 200 µM -1.39532516840935 0.057124746613053 no 3132 0.081458902869348 4441 270010
SGTC_1085 doxorubicin 7.67 µM -1.39655890938553 0.0569608348999458 no 3133 0.0812731270423655 4439 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2990 9074105 71.4286 µM -1.39936721612529 0.0565891112622606 no 3134 0.0808514463329272 4342 6502001
SGTC_302 1094-0063 18.9 µM -1.40019789333574 0.0564795251215394 no 3135 0.0807270332704735 4401 5440289
SGTC_666 0272-0154 136 µM -1.40178069847607 0.0562711783597302 no 3136 0.0804903719667475 4431 6870312
SGTC_3130 9127414 49.47 µM -1.40581180439362 0.0557432947596557 no 3137 0.0798900079266373 4451 1494646
SGTC_543 3844-1095 191 µM -1.40721963997018 0.055559858530425 no 3138 0.0796811347910093 4447 4230703
SGTC_1425 4048-4433 7.33 µM -1.40889106199403 0.0553426969157112 no 3139 0.0794336914328659 4503 23734946
SGTC_1167 k781-0610 148 µM -1.41114284256707 0.0550511919271503 no 3140 0.0791012497945817 4470 4525169
SGTC_2068 5226020 147 µM -1.41788577692524 0.0541855344589262 no 3141 0.0781120577725912 4452 1810509
SGTC_2100 5377183 190 µM -1.42455250030666 0.0533402860932075 no 3142 0.0771432994162619 4480 2844202
SGTC_3302 9125395 16.351 µM -1.42646243238151 0.0531000686454536 no 3143 0.0768674517407999 4403 17599668
SGTC_129 0088-0017 176.636 µM -1.43091245427047 0.0525437044715343 no 3144 0.0762276536045355 4305 182446
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.43240666393553 0.0523579319096188 no 3145 0.0760137362574665 4463 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1238 0333-0287 48.8 µM -1.43926711748293 0.0515116681259102 no 3146 0.075037427785643 4445 7226
SGTC_2234 tolnaftate 200 µM -1.44131590806176 0.0512610619964428 no 3147 0.0747477275348948 4569 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2178 5812956 200 µM -1.44192008258551 0.0511873454237528 no 3148 0.0746624600357396 4434 5403383
SGTC_1038 k292-0204 154 µM -1.44561149680631 0.0507387787837986 no 3149 0.0741431000919724 4403 4454212
SGTC_948 3448-0295 75.3 µM -1.44641978557588 0.0506409775859671 no 3150 0.0740297478379838 4446 678569
SGTC_3088 9117578 49.47 µM -1.44700077648935 0.0505707717346668 no 3151 0.073948353046782 4527 678341
SGTC_2417 cerulenin 830 nM -1.44736322832431 0.0505270130210229 no 3152 0.0738976094623333 4475 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_142 0335-0849 62.6745 µM -1.45476219751309 0.0496403130319301 no 3153 0.0728675534497256 4436 3889043 YPR107C YTH1
SGTC_984 1492-0255 2.91 µM -1.45487375895688 0.0496270390346167 no 3154 0.0728521068438171 4436 1585198
SGTC_2377 9073351 62.6 µM -1.45640063987316 0.0494456495577407 no 3155 0.0726409493937401 4466 7337946 YHR072W ERG7
SGTC_2018 5133068 143 µM -1.45788227989144 0.0492701408986287 no 3156 0.0724364968627602 4435 785362
SGTC_1773 st048542 73.5835 µM -1.45891189701759 0.0491484701273294 no 3157 0.0722946791141608 4455 3237138
SGTC_2313 7726885 200 µM -1.46168692480371 0.0488217373528831 no 3158 0.0719135109381605 4490 726423
SGTC_1109 tnp00067 928.257 nM -1.46327826629085 0.0486351567772326 no 3159 0.0716956261217802 4477 676295
SGTC_1068 loratadine 26.9 µM -1.46495787861924 0.0484388454758912 no 3160 0.071466205057226 4519 3957 A H1 histamine antagonist.
SGTC_1105 epirubicin 18.1 µM -1.46632259456464 0.0482798059917603 no 3161 0.0712802114149746 4512 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2857 9024691 58.44 µM -1.46654645605821 0.0482537578387753 no 3162 0.0712497374141224 4500 16478292
SGTC_2971 9092186 9.93 µM -1.46678804098092 0.048225660031526 no 3163 0.0712168619660904 4443 25236400
SGTC_303 1348-1668 34.2 µM -1.46954376933973 0.0479060773319007 no 3164 0.0708426795831034 4485 5380509
SGTC_814 3342-0569 96 µM -1.47504814172128 0.0472728096440167 no 3165 0.0700998005041902 4509 4346283
SGTC_1833 st055984 71 µM -1.48232324546514 0.0464461359585116 no 3166 0.0691271529939815 4513 676288
SGTC_2904 7225135 42.03 µM -1.48942841228779 0.0456500126423485 no 3167 0.0681872957102995 4551 4446116
SGTC_433 pimozide 108 µM -1.49710282405759 0.0448024687149154 no 3168 0.0671832525288055 4408 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_118 0083-0097 135.343 µM -1.49968695151774 0.0445199518100141 no 3169 0.066847756075915 4472 5207356
SGTC_2319 6033012 152.6 µM -1.50401135589668 0.0440503863271976 no 3170 0.0662892214029483 4451 847246
SGTC_2470 5664817 21.68 µM -1.50532484430669 0.043908554536118 no 3171 0.0661202904114391 4544 2859561
SGTC_2824 7998404 51.95 µM -1.50797079529576 0.0436239604688424 no 3172 0.0657810008749938 4474 837851
SGTC_1737 st035557 69.7 µM -1.50944453431991 0.0434660941500468 no 3173 0.0655926097643478 4341 5716916
SGTC_1474 0330-0125 5.35 µM -1.51222556579599 0.0431694475743289 no 3174 0.0652382446499137 4562 X1474
SGTC_1339 1486-1321 22.7 µM -1.51410345266542 0.0429700639294994 no 3175 0.0649998015616239 4539 3469382
SGTC_520 3584-0023 682 µM -1.51475502114574 0.0429010581109961 no 3176 0.0649172274646248 4502 1340790
SGTC_3011 9081274 71.4286 µM -1.51525869502552 0.0428477767924489 no 3177 0.0648534520614934 4502 6625322
SGTC_144 4161-2749 112.381 µM -1.51733242165526 0.0426289700108743 no 3178 0.0645913882154316 4493 797501 YMR168C CEP3
SGTC_3250 9135583 49.47 µM -1.51782476558066 0.0425771538595231 no 3179 0.0645292900408489 4512 7699353
SGTC_298 1391-0729 10 µM -1.51868748217731 0.0424864810912067 no 3180 0.064420589483409 4455 3237558
SGTC_1483 3453-0561 55.9 µM -1.52110830151997 0.0422328831470805 no 3181 0.0641163307856291 4529 4546991
SGTC_2517 totarol 10 µM -1.52339588995058 0.041994368969747 no 3182 0.0638298448378324 4509 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1144 3486-0183 12.5 µM -1.52456105210767 0.041873303769413 no 3183 0.0636843090678113 4519 6744069
SGTC_1391 3442-0225 151 µM -1.5291320730313 0.0414010820082987 no 3184 0.0631158528658829 4488 5227075
SGTC_3092 9117248 49.47 µM -1.53359561937364 0.0409441372035514 no 3185 0.0625645833430323 4624 17141857
SGTC_2569 tetrandrine 100 µM -1.53496817098868 0.0408044507911956 no 3186 0.0623958232927163 4510 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1723 st034307 2.5525 µM -1.5384528204068 0.0404515497852045 no 3187 0.0619689678976674 4504 867466
SGTC_1700 st030840 7.9285 µM -1.53899322784441 0.0403970436955788 no 3188 0.0619029747719968 4565 5499307
SGTC_3273 9137859 49.47 µM -1.53964207233931 0.0403316793280503 no 3189 0.0618238120775902 4593 2377234
SGTC_655 k060-0012 42 µM -1.54142611423124 0.0401523982310426 no 3190 0.0616065562045124 4502 5994525
SGTC_2406 ethylparaben 405.7 µM -1.5481567716991 0.0394818446319932 no 3191 0.0607922781544472 4470 8434 A possible steroid mimic.
SGTC_1045 1348-1485 165 µM -1.54962958537035 0.0393363344739695 no 3192 0.0606152238542401 4498 6810614
SGTC_1819 st053448 58.6 µM -1.55045603831518 0.0392548743906489 no 3193 0.060516048639663 4461 2857616
SGTC_3032 9089427 49.47 µM -1.55713722699494 0.0386013662507126 no 3194 0.059718954088009 4500 17173707
SGTC_3169 9102970 49.47 µM -1.55739923784487 0.0385759198894814 no 3195 0.0596878634976723 4595 17027839
SGTC_2171 5739187 198.077 µM -1.55917591787014 0.0384037300278833 no 3196 0.0594773745146912 4495 2262761
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.5643646609792 0.0379044385401216 no 3197 0.0588659774343725 4536 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1224 0823-0416 294 µM -1.56505145457483 0.037838749944542 no 3198 0.0587854224774442 4555 3598164
SGTC_856 0433-0016 11.3 µM -1.56663893200924 0.0376872706554991 no 3199 0.0585995561862441 4555 3911780
SGTC_1986 st071812 45 µM -1.56864966259287 0.0374961149504577 no 3200 0.058364796870648 4475 11838594
SGTC_2694 st077685 81.9 µM -1.56867814653258 0.0374934127436155 no 3201 0.058361476592185 4456 2838096
SGTC_709 3807-1509 243 µM -1.57934905462428 0.0364922213644267 no 3202 0.05712800794595 4600 1886677 YPL242C IQG1
SGTC_2241 6772625 37.8075 µM -1.57953838301937 0.036474657216259 no 3203 0.0571063098766118 4336 2285411
SGTC_2023 5144124 124 µM -1.58219056385046 0.036229338663151 no 3204 0.0568030369341754 4496 2830192
SGTC_2326 6164455 177.58 µM -1.58593382770056 0.0358853985598832 no 3205 0.0563771605931117 4472 2888790
SGTC_313 3474-0040 5.03 µM -1.59358522094661 0.0351906908968997 no 3206 0.055514483413227 4560 1043375 YIL048W NEO1
SGTC_1696 st025591 34.7925 µM -1.59511747411892 0.0350529046926259 no 3207 0.0553429842991826 4538 2787147
SGTC_708 3448-5400 146 µM -1.59512548091635 0.0350521858545007 no 3208 0.0553420892297065 4503 3462195
SGTC_2614 arthonioic acid 13.39 µM -1.60272923645425 0.0343749727895388 no 3209 0.0544972229031722 4417 6710684
SGTC_1910 st062352 60.4 µM -1.61595009548559 0.0332231009430709 no 3210 0.0530525516660485 4475 2245730
SGTC_251 melphalan 456.522 µM -1.61789718669472 0.0330561771061593 no 3211 0.0528423783422919 4585 460612 A DNA alkylator.
SGTC_1437 4092-1038 11.6 µM -1.62161138760891 0.0327396756331498 no 3212 0.0524432914127984 4608 3977136
SGTC_1253 0550-0034 176 µM -1.62441883864519 0.0325021034632019 no 3213 0.052143224581486 4546 5969915
SGTC_141 0443-0274 32.331 µM -1.62560123054657 0.0324024735544399 no 3214 0.0520172566381063 4491 1627241
SGTC_1116 jasmonic acid 1.58368 µM -1.62628259942194 0.032345175042709 no 3215 0.0519447758329862 4594 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3241 9133421 49.47 µM -1.62667923872981 0.0323118588802962 no 3216 0.051902620183395 4636 17018221
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.63037022592743 0.0320031861833804 no 3217 0.0515116367312655 4551 1377
SGTC_1107 amlodipine 47 µM -1.63467116547449 0.0316465799017269 no 3218 0.0510590001220587 4137 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1003 4049-0218 100 µM -1.63902922299797 0.0312885935891797 no 3219 0.0506035868798251 4567 295161
SGTC_136 0097-0015 404.482 µM -1.64543327776639 0.0307686237833751 no 3220 0.0499402458359105 4554 4861337
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.64602036266119 0.0307213161925097 no 3221 0.0498797833840357 4535 16623 A steroid.
SGTC_3290 9121031 71.43 µM -1.6470631786394 0.030637434065873 no 3222 0.049772530264129 4571 17014854
SGTC_3332 9141069 11.198 µM -1.65413583750266 0.0300735151665105 no 3223 0.0490499579829967 4516 17332883
SGTC_1202 1988-0068 29.6 µM -1.66358650479888 0.0293334508105127 no 3224 0.0480975453062335 4553 2850480
SGTC_1638 st008370 60.6 µM -1.66839743974847 0.0289625629814311 no 3225 0.0476184280919707 4527 24207134
SGTC_1352 1496-0991 99 µM -1.66894814787047 0.0289203571149961 no 3226 0.0475638281954451 4584 3000039
SGTC_1721 st082152 9.2685 µM -1.67028223446933 0.0288183255804668 no 3227 0.0474317682043786 4515 5296051
SGTC_2621 lithochol-11-enic acid 100 µM -1.67196840372277 0.0286897949318436 no 3228 0.0472652763668788 4524 6708711
SGTC_3077 9117319 49.47 µM -1.68353600779572 0.0278208328737842 no 3229 0.0461356874320962 4538 17154678
SGTC_662 k832-1615 104 µM -1.68549871590752 0.0276755919198141 no 3230 0.0459461961765052 4607 5878478
SGTC_1902 st060212 70.5 µM -1.68599423704684 0.0276390232918455 no 3231 0.0458984546827587 4575 688944
SGTC_3288 9119690 36.221 µM -1.68654486299543 0.0275984352702665 no 3232 0.0458454508243076 4565 17595618 YKL019W RAM2
SGTC_843 0310-0051 143 µM -1.69316307072456 0.0271144660952151 no 3233 0.0452122158788404 4598 2065037
SGTC_970 1315-0089 19.5 µM -1.71911971317357 0.0252841718763451 no 3234 0.0427962879906249 4583 6811083 YLR033W RSC58
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.72283776665741 0.0250306753275402 no 3235 0.0424589335135014 4587 6312947
SGTC_1187 1391-0724 117 µM -1.72477744789353 0.0248992759570664 no 3236 0.0422837937384524 4640 6997986
SGTC_1597 7-benzyloxygramine 47.5 µM -1.74061532538516 0.0238478677928879 no 3237 0.0408755147413111 4506 260807
SGTC_1299 1079-1439 3.74 µM -1.74778346216007 0.0233844183962172 no 3238 0.0402507650271336 4603 323161
SGTC_78 0336-0123 156.75 µM -1.75917982150012 0.0226632105652989 no 3239 0.0392734852377099 4491 6765896
SGTC_819 1013-0258 27.7 µM -1.7611644726057 0.0225395505269946 no 3240 0.0391052846520028 4618 5753198
SGTC_1905 st060207 84.5 µM -1.76316023173862 0.0224157725528673 no 3241 0.0389367344714025 4603 1948547
SGTC_1335 1486-0900 202 µM -1.7685679160542 0.0220832632421364 no 3242 0.038483004462766 4615 X1335
SGTC_509 pifithrin 175 µM -1.77293324317631 0.0218178924613426 no 3243 0.0381198846791094 4692 4817 A p53 inhibitor.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.77571563845047 0.021650158430302 no 3244 0.0378898992410255 4622 390807
SGTC_1259 0671-0132 43 µM -1.77644302925386 0.0216064884595419 no 3245 0.0378299620916033 4558 X1259
SGTC_1547 harmine 94.2 µM -1.7782588801838 0.0214977959321768 no 3246 0.0376806732409848 4546 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2424 5537928 59.2 µM -1.78753086814747 0.0209499755178056 no 3247 0.0369258638223206 4620 5382802
SGTC_1126 isoteolin 1.0172 µM -1.7994766498147 0.0202616363680518 no 3248 0.0359716571588051 4562 133323
SGTC_3285 9112818 20.8695 µM -1.80059399956232 0.0201982444777791 no 3249 0.0358834478180482 4620 17017947 YPR165W RHO1
SGTC_396 dithiazanine 1.25 µM -1.80142567653152 0.0201511692337821 no 3250 0.0358179060630551 4594 10578 An antihelmenthic.
SGTC_924 2046-0044 21.3 µM -1.80328847892797 0.0200460668974149 no 3251 0.0356714605299492 4595 3623589
SGTC_3191 9110352 49.47 µM -1.80643586262614 0.0198695429491484 no 3252 0.0354251420123183 4586 17122424
SGTC_1574 spiramycin 23.7 µM -1.81213713647569 0.0195531399498569 no 3253 0.0349825047390383 4608 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1943 st076331 65.2 µM -1.81729024426646 0.0192708502436489 no 3254 0.0345863414860911 4615 24208415
SGTC_1189 1431-2119 7.28 µM -1.82917873509178 0.0186327802002401 no 3255 0.033686418485138 4642 3107275
SGTC_2961 9083290 32.55 µM -1.83224722242586 0.0184710411932315 no 3256 0.0334572981427496 4613 17741490
SGTC_3000 9075062 71.4286 µM -1.83459843491969 0.0183479199811388 no 3257 0.0332826053772513 4626 17057871
SGTC_2132 5317594 122.667 µM -1.84609827926324 0.0177557553436223 no 3258 0.032438968332611 4584 794577
SGTC_399 oxolinic acid 75 µM -1.8484655237961 0.0176359032456947 no 3259 0.0322675136943648 4633 4628 A DNA gyrase inhibitor.
SGTC_1092 toremifene 6.32 µM -1.85221800495364 0.0174473323494599 no 3260 0.0319972621669016 4649 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_233 rapamycin 362 pM -1.85400813683453 0.0173579823279014 no 3261 0.0318689979491419 4658 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2059 5238311 157 µM -1.85801963907622 0.0171591762316089 no 3262 0.0315831127284811 4603 703021
SGTC_980 1473-0395 201 µM -1.85807409091466 0.017156491093022 no 3263 0.0315792467724657 4583 768876
SGTC_1247 0448-0043 5.84 µM -1.85943931363783 0.0170892862496362 no 3264 0.031482446841629 4606 3089013 YGL099W LSG1
SGTC_231 b-estradiol 524 µM -1.86760153265275 0.0166921666680978 no 3265 0.0309088163213737 4662 450 A steroid.
SGTC_1934 st074720 32.6 µM -1.86834208959986 0.0166565299227153 no 3266 0.0308572017143422 4595 17250992
SGTC_2832 7992762 51.95 µM -1.87099564568365 0.0165293707622942 no 3267 0.0306728422800212 4559 2985177
SGTC_1171 0368-0077 21.4 µM -1.87128065775014 0.016515762449303 no 3268 0.0306530950347482 4626 3239779
SGTC_850 0388-0143 75.9 µM -1.8806283538892 0.0160747280197279 no 3269 0.0300112459700031 4662 67273
SGTC_3005 9076496 71.4286 µM -1.8853794336033 0.0158544620230181 no 3270 0.0296893143352399 4630 21368410
SGTC_510 ag-490 170 µM -1.88845433940831 0.015713289339725 no 3271 0.0294824911285286 4740 5328779
SGTC_594 1487-1584 10.8 µM -1.89134930338881 0.0155813649096734 no 3272 0.0292888656315303 4645 5013332
SGTC_3276 9139060 49.47 µM -1.89594287850517 0.0153739850512703 no 3273 0.0289837991046407 4698 4870619
SGTC_1915 st067105 30.6 µM -1.89872678090187 0.0152494609464366 no 3274 0.0288002042339224 4594 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2051 5263410 176 µM -1.91877207463561 0.0143781510600764 no 3275 0.0275065927183207 4618 227584
SGTC_624 k048-0052 28 µM -1.92058748464207 0.0143014005131676 no 3276 0.0273918671140472 4670 6835531
SGTC_1488 4013-0813 75.9 µM -1.94019374566727 0.013494734905801 no 3277 0.0261780741645795 4699 2910057
SGTC_2434 5670830 169.91 µM -1.94984519652495 0.0131122803887474 no 3278 0.0255972863817673 4661 1549830
SGTC_195 4234-0266 16.654 µM -1.95679066988949 0.0128428841501433 no 3279 0.0251860422373022 4699 2303354
SGTC_2512 diallyl trisulfide 49.23 µM -1.96277796024237 0.0126145087383192 no 3280 0.0248359899078371 4700 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.96385838363319 0.0125736743040873 no 3281 0.0247732585934272 4610 5355888
SGTC_787 4152-0075 138 µM -1.96623609053634 0.0124842120583375 no 3282 0.0246356726678812 4692 9566539
SGTC_664 1222-0054 14.9 µM -1.96652518432462 0.0124733724512135 no 3283 0.0246189880662922 4672 6813991
SGTC_269 exalamide 29 µM -1.97203891826136 0.0122681888389179 no 3284 0.0243025819546714 4674 3316 A derivative of salicylamide.
SGTC_1674 st016616 23.6 µM -1.97256322432634 0.0122488308755702 no 3285 0.0242726731966096 4655 625830
SGTC_2197 6588183 93.1375 µM -1.97627432301418 0.0121125681439654 no 3286 0.0240618580563175 4708 884136
SGTC_1193 1488-0126 41.5 µM -1.98192840412997 0.0119074902031758 no 3287 0.0237436271839097 4669 1384710
SGTC_1637 st007924 17.4 µM -1.98793194792505 0.0116930404805936 no 3288 0.0234096084147688 4619 683336
SGTC_2265 7929201 200 µM -1.99448194735001 0.011462902782041 no 3289 0.0230497054497407 4663 1265108
SGTC_2805 7950783 58.44 µM -1.99851808770763 0.0113230586804912 no 3290 0.0228302604806272 4666 1178958 YDL195W SEC31
SGTC_3331 9141060 1.957 µM -2.00039933075896 0.0112583855826556 no 3291 0.0227285803024983 4665 4906567 YPR165W RHO1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -2.01128851496754 0.0108903112098149 no 3292 0.022147495454647 4725 279621
SGTC_2826 7992541 19.48 µM -2.01600906108905 0.010734030438007 no 3293 0.0218995141502247 4672 2985066
SGTC_1387 3342-1166 1.8 µM -2.04926118671187 0.00968746950349128 no 3294 0.0202182909065945 4707 3418228
SGTC_2304 7443016 91.4 µM -2.0545118351175 0.00953063711091852 no 3295 0.0199630895463895 4654 939854
SGTC_423 5-fluorouracil 457 µM -2.06650237684218 0.00918078793006417 no 3296 0.0193905341050612 4634 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_834 0312-0008 75.7 µM -2.08794595358494 0.00858308712751125 no 3297 0.0184013551250698 4725 6385573 YIL048W NEO1
SGTC_2315 7733312 200 µM -2.10195500293854 0.00821129918882809 no 3298 0.0177786088289784 4644 726316
SGTC_347 4534-1311 26.2 µM -2.10299182882365 0.00818435362393391 no 3299 0.0177332418874611 4700 2862016
SGTC_631 k072-0230 41.5 µM -2.11837798755511 0.00779352403411422 no 3300 0.0170715342947012 4714 5773147
SGTC_3279 9140807 49.47 µM -2.12344019939673 0.0076685768001243 no 3301 0.0168584908096008 4741 45595718
SGTC_504 lovastatin 124 µM -2.13037363929683 0.00750030629486883 no 3302 0.0165703891650847 4700 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1898 st060199 18.6 µM -2.13727414199643 0.00733607315678662 no 3303 0.0162878503721557 4722 688866
SGTC_668 1682-0499 62.6 µM -2.14344402481676 0.00719192171661171 no 3304 0.0160387306061277 4719 682214
SGTC_1722 st034304 3.6505 µM -2.15708266059936 0.0068821059821079 no 3305 0.0154996121913088 4655 4036148 YLR033W RSC58
SGTC_2459 5811157 9.22 µM -2.1625594969806 0.0067610492538949 no 3306 0.0152875381613747 4688 2870684 YBR192W RIM2
SGTC_1065 prochlorperazine maleate 2.48 µM -2.16915852736041 0.00661769033099158 no 3307 0.0150353252698148 4749 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3159 9100096 49.47 µM -2.17802434046894 0.00642932071883802 no 3308 0.0147021123316462 4676 25236875
SGTC_2900 5328528 85.29 µM -2.1963434883653 0.00605506321660206 no 3309 0.0140336836138377 4686 795359
SGTC_1478 0453-0656 35.7 µM -2.19698155227997 0.00604238301895834 no 3310 0.0140108818732265 4763 5258496
SGTC_1337 1486-1011 40.3 µM -2.23641272026964 0.0053030282506423 no 3311 0.0126623743367972 4734 X1337
SGTC_981 1488-1094 54.9 µM -2.24902767757037 0.00508409929090312 no 3312 0.0122553676080831 4708 3449522
SGTC_2356 9061756 188.97 µM -2.26732447290622 0.00478086033626104 no 3313 0.0116852057635439 4748 20104043
SGTC_1839 st053978 48 µM -2.26895740973246 0.00475459734371759 no 3314 0.011635457992029 4754 3788398
SGTC_1049 3226-0134 66 µM -2.26930330382216 0.00474905077078767 no 3315 0.0116249438855625 4731 5702385
SGTC_1051 3253-3903 78 µM -2.29297144908926 0.00438295936358747 no 3316 0.0109248243723888 4735 5509239
SGTC_309 k408-0051 1.48 µM -2.3007884034312 0.00426771123102837 no 3317 0.0107017971266486 4670 3640463
SGTC_1947 st076332 61.6 µM -2.30615941467619 0.00419010266193424 no 3318 0.0105508632102545 4656 24208416
SGTC_2987 9018338 71.43 µM -2.31487722745425 0.00406681916018327 no 3319 0.0103098259793693 4733 5055682
SGTC_2449 5812982 45.77 µM -2.3208435894922 0.00398432721416839 no 3320 0.0101476434926735 4689 776185
SGTC_430 0958-0115 16.4 µM -2.33400905782419 0.00380757834965595 no 3321 0.0097976238185066 4696 6833180
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.36049730473916 0.00347311450950874 no 3322 0.00912522546940633 4701 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1447 4239-0816 81.9 µM -2.37922086384782 0.00325287046461683 no 3323 0.00867463867982815 4762 1341554
SGTC_750 4073-0104 132 µM -2.38208486807273 0.00322031236630067 no 3324 0.00860746476290425 4519 22330957
SGTC_2760 etidronate 98.04 µM -2.39700713092316 0.00305537185126906 no 3325 0.00826480101107951 4718 3305 A chelator and antioxidant.
SGTC_3294 9122953 26.2835 µM -2.40586996834462 0.00296104825368042 no 3326 0.00806700311993611 4732 16459826
SGTC_2907 7721985 69.9 µM -2.41027858135349 0.00291511355530314 no 3327 0.00797017185713871 4735 3267881
SGTC_860 0443-0016 25.1 µM -2.41638650071689 0.00285253476994032 no 3328 0.00783770619564225 4763 5337942
SGTC_286 k060-0067 22.9 µM -2.45914562661551 0.00244731685021954 no 3329 0.00696340566535635 4773 5985051
SGTC_1752 st044819 83.042 µM -2.46517540469284 0.00239456936646733 no 3330 0.00684730966719636 4717 441209 YML126C ERG13
SGTC_2332 7982454 138.89 µM -2.47550508363245 0.00230659313971116 no 3331 0.00665239337949625 4707 2981748
SGTC_1995 st072814 61.1 µM -2.49966405873104 0.00211215330246047 no 3332 0.00621555627859731 4765 5769371
SGTC_599 1935-0052 86.5 µM -2.51797500369224 0.00197481977103786 no 3333 0.00590158486206858 4766 9557311
SGTC_2964 9083345 53.42 µM -2.52083328002007 0.00195412971605963 no 3334 0.00585386542924602 4740 17741579
SGTC_301 4119-0100 24.5 µM -2.52540517947164 0.00192144438183389 no 3335 0.00577824814769604 4770 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2314 7727897 200 µM -2.56982323748117 0.00162879758475716 no 3336 0.00508752090268075 4735 900724
SGTC_1135 dihydrocapsaicin 536.708 nM -2.57361026900726 0.00160582935899109 no 3337 0.00503217851912244 4729 107982 A Capsaicinoid.
SGTC_2135 5326629 150.42 µM -2.59775868450405 0.00146617963102894 no 3338 0.00469172059427354 4748 5020077
SGTC_1743 st037606 46.3785 µM -2.62910436494575 0.00130144621038462 no 3339 0.00428050414918924 4740 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_630 4356-0227 183 µM -2.63723931173349 0.00126155366937443 no 3340 0.00417919210086086 4756 779312
SGTC_521 r062-0005 13.8 µM -2.67281976205987 0.00109988408879776 no 3341 0.0037608325602006 4749 2832033
SGTC_2806 7952793 58.44 µM -2.73934690816834 0.000847491002621641 yes 3342 0.00307806889630471 4762 2972490
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -2.75971262622778 0.000781618983611614 yes 3343 0.00289261132361942 4773 688761
SGTC_157 1348-1695 65.819 µM -2.76631541775216 0.000761296230879546 yes 3344 0.00283468348512401 4737 5380510
SGTC_2911 7942208 15.64 µM -2.80888434997414 0.000641530509264312 yes 3345 0.0024856750800612 4776 1243384
SGTC_1695 st026914 34.495 µM -2.81560245445521 0.00062430265809824 yes 3346 0.00243429352255781 4798 3289191
SGTC_1071 trifluoperazine 6.31 µM -2.82424037514137 0.000602779342388586 yes 3347 0.00236964134038636 4789 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3154 9100113 49.47 µM -2.84231659829208 0.000559938901733014 yes 3348 0.00223934956478065 4768 25237525
SGTC_2903 5923464 63.88 µM -2.85705794955727 0.000527105207288307 yes 3349 0.00213793882557321 4780 2876576
SGTC_2293 7624732 200 µM -3.06416312123804 0.000219067017364416 yes 3350 0.00109139928198081 4765 894453
SGTC_300 r073-0011 5.04 µM -3.14119179837608 0.000155855525810225 yes 3351 0.000841309004990348 4807 2735780
SGTC_1573 oleylamine 1.06 µM -3.20657067515982 0.000116052668294497 yes 3352 0.000671636519666135 4786 5356789 An amine of the fatty acid oleic acid.
SGTC_1993 st073995 70.8 µM -3.96098815169997 2.5981744037023e-06 yes 3353 3.73201183823551e-05 4805 3098394
SGTC_614 0462-0418 107 µM -4.38313475682524 2.24894091962801e-07 yes 3354 5.84918501599616e-06 4751 5188303
SGTC_613 3914-0030 117 µM -6.28548223865902 2.02083009743631e-13 yes 3355 1.63418765976605e-10 4771 1145395