SGTCid condition conc unit AZF1|YOR113W.score AZF1|YOR113W.strain.pval AZF1|YOR113W.strain.significant AZF1|YOR113W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_8 0354-0001 70 µM 7.40535360591572 7.172341070451e-13 yes 1 6.54007311873396e-14 13 4993152 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 6.82236976953667 3.51679830258499e-11 yes 2 4.47754004172783e-12 5 16725076 SGTC_1937 st074714 47.2 µM 5.46831373693462 9.06572549417584e-08 yes 3 2.271685833055e-08 18 17250970 SGTC_1282 0886-0010 32.4 µM 5.3688593892692 1.51251842160807e-07 yes 4 3.96180822147964e-08 15 2836211 YNL267W PIK1 SGTC_2332 7982454 138.89 µM 5.31725390303631 1.96576213053921e-07 yes 5 5.2672510714409e-08 24 2981748 SGTC_1087 pterostilbene 9.05 µM 4.91121592136756 1.42255471004078e-06 yes 6 4.5256674517233e-07 7 5281727 Similar to reservatol, lowers cholesterol. SGTC_1028 k015-0029 4.8 µM 4.62389714472875 5.28093643663742e-06 yes 7 1.88298329119177e-06 13 4588309 SGTC_3333 9141820 12.094 µM 4.56626526312526 6.80981156902355e-06 yes 8 2.48245215003094e-06 10 1939433 SGTC_1015 4130-4525 82 µM 4.43044757417887 1.22547710408425e-05 yes 9 4.70188537595154e-06 11 1363237 SGTC_812 4251-0442 148 µM 4.31251797025931 2.01425267186088e-05 yes 10 8.07028795064984e-06 7 5723007 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 4.20612050032743 3.12060589982838e-05 yes 11 1.29895875620467e-05 33 6710655 SGTC_2210 7115885 190.385 µM 3.94483092107319 8.76521118205408e-05 yes 12 3.99281521452493e-05 33 2927039 SGTC_550 4123-0385 25.7 µM 3.92923739739343 9.30477156212561e-05 yes 13 4.26078400755115e-05 24 5731123 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 3.85936481197792 0.000121287836344102 yes 14 5.6841062061107e-05 35 688664 SGTC_2560 caryophyllene 100 µM 3.76466330831316 0.00017253174642992 yes 15 8.33868222358548e-05 21 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_6 0844-0013 19.835 µM 3.73367021298882 0.000193294124359335 yes 16 9.43547787224814e-05 111 1584900 SGTC_836 0330-0104 1.35 µM 3.55677339557184 0.000363848020756881 yes 17 0.000187718868422319 25 46494820 SGTC_756 0508-1999 28.3 µM 3.54649611916671 0.000377151364843332 yes 18 0.000195195246173345 43 6753853 SGTC_1549 4'-methoxyflavonol 74.6 µM 3.43563939306075 0.000552339895287956 yes 19 0.000295578630555195 16 97141 SGTC_1631 benzylvanillin 81.9 µM 3.41853189607114 0.000585279707155986 yes 20 0.000314799690476346 46 75506 SGTC_3006 9075424 71.4286 µM 3.1943377004535 0.00122148481553306 no 21 0.000700760328791363 38 7465181 SGTC_1608 st001473 40.5 µM 3.1683588035236 0.00132646653501287 no 22 0.000766510969512843 68 7292267 SGTC_615 k087-0205 167 µM 3.13812569564121 0.00145898552684074 no 23 0.000850159726472895 39 9642773 SGTC_1853 st056710 91.2 µM 3.12605796983403 0.00151517465239205 no 24 0.00088583312169808 57 269167 SGTC_1774 st048371 48.465 µM 3.10842281238453 0.00160084119552334 no 25 0.000940443850685809 59 4242727 SGTC_703 3875-0075 71.8 µM 3.10714585550075 0.00160721248076497 no 26 0.000944515855305269 23 2850814 SGTC_1019 4262-0212 3.4 µM 3.10552619580576 0.00161532689659072 no 27 0.000949703978443669 125 4677213 SGTC_1405 3909-7894 12 µM 3.07396015687404 0.00178111052793349 no 28 0.00105618820932505 36 7104060 SGTC_1443 4112-3303 14 µM 3.04627495405134 0.00193909630201416 no 29 0.00115847926077514 34 704433 SGTC_1865 st057639 52.2 µM 3.0397867908625 0.00197791589460908 no 30 0.0011837284048581 43 688818 SGTC_3339 9145883 14.936 µM 3.02435811906207 0.00207307773448529 no 31 0.00124580654446964 47 2030670 SGTC_1619 st003326 88.7 µM 3.01659536982004 0.00212251147817849 no 32 0.0012781539499206 49 2849032 SGTC_1207 2099-0101 141 µM 2.98239970382071 0.00235324612521741 no 33 0.00142999169736822 70 5837381 SGTC_1934 st074720 32.6 µM 2.92882807238415 0.00276062096823428 no 34 0.00170121280913041 110 17250992 SGTC_1752 st044819 83.042 µM 2.92364064754186 0.00280326751763509 no 35 0.00172981944910727 69 441209 YML126C ERG13 SGTC_2236 dapsone 200 µM 2.9211982988357 0.00282355146998848 no 36 0.00174343906354939 40 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1336 1486-0901 104 µM 2.85730944003985 0.00340344824928711 no 37 0.00213624546120753 67 5006114 SGTC_1159 4092-0538 61.2 µM 2.8105873657888 0.00389305248193523 no 38 0.0024725580620571 83 717301 SGTC_2441 5730946 39.09 µM 2.79960933675284 0.00401687736594738 no 39 0.00255822429823818 74 1774275 SGTC_237 nikkomycin 200 µM 2.79250752671136 0.00409884801749634 no 40 0.0026150625407975 71 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_533 1222-0222 6.71 µM 2.78720173512781 0.00416106225863015 no 41 0.00265826853529364 85 3982874 SGTC_1816 st051957 91.6 µM 2.78596714416541 0.00417565933859146 no 42 0.00266841403741443 60 674121 SGTC_2163 5671233 125 µM 2.76235955283421 0.00446373503760631 no 43 0.00286926224015625 97 701023 SGTC_1782 st039423 80.636 µM 2.75307437453035 0.00458181773251056 no 44 0.00295192411123624 98 2068169 SGTC_2691 st077356 60.2 µM 2.73881035124788 0.00476865374089437 no 45 0.00308309657470686 96 2839272 SGTC_1673 st016611 27.3 µM 2.72775283413858 0.00491813321981056 no 46 0.00318836842521008 129 5226799 SGTC_2290 7904846 200 µM 2.72417017998296 0.00496745260890635 no 47 0.0032231640281342 106 2962154 SGTC_1986 st071812 45 µM 2.72409011475353 0.00496855981492448 no 48 0.00322394552871098 52 11838594 SGTC_1688 st021091 57.6 µM 2.72290250662327 0.00498500884479604 no 49 0.00323555756714005 37 3656366 SGTC_821 1114-0266 29.2 µM 2.71280950292043 0.00512677198399196 no 50 0.0033357723492673 81 3123235 SGTC_1680 diphenhydramine 100 µM 2.69816834039677 0.00533879608855023 no 51 0.00348610867425248 106 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_883 0850-0245 24.6 µM 2.66312057302981 0.00587831561463918 no 52 0.00387098338886837 105 6823229 YPR165W RHO1 SGTC_3321 9137793 26.8275 µM 2.65278526466702 0.00604639137257381 no 53 0.00399153197886999 159 4904192 SGTC_624 k048-0052 28 µM 2.64305460319722 0.00620851285043136 no 54 0.00410808920343784 92 6835531 SGTC_1757 st041620 31.8375 µM 2.63522970504487 0.0063416632813399 no 55 0.00420401807826584 108 5289815 SGTC_369 0957-0393 4.5 µM 2.61577193135171 0.00668377804186533 no 56 0.00445130000814532 105 6997992 SGTC_814 3342-0569 96 µM 2.61492301342596 0.00669906858585654 no 57 0.00446237847112512 115 4346283 SGTC_2449 5812982 45.77 µM 2.60952481232615 0.00679702526480022 no 58 0.00453340352595787 65 776185 SGTC_1513 0337-0559 19 µM 2.60061917811193 0.00696139591370302 no 59 0.00465278451307716 108 775073 SGTC_2097 5376186 200 µM 2.58296884445795 0.00729756705179805 no 60 0.00489770841239512 106 742755 SGTC_3010 9080089 71.4286 µM 2.57002812993776 0.00755305194560353 no 61 0.00508451286568186 95 17027233 SGTC_459 nigericin 15.3 µM 2.56926442258098 0.00756837281967376 no 62 0.00509573294854461 151 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1344 1488-0097 29.1 µM 2.56450567153864 0.00766445703666071 no 63 0.00516614453603338 101 747966 SGTC_1602 st001878 87.6 µM 2.56285170145846 0.00769810303619574 no 64 0.00519081906965295 93 595405 YLR310C CDC25 SGTC_2308 7584454 197.62 µM 2.54742705818282 0.0080181921622999 no 65 0.00542602686773501 137 893577 SGTC_2652 actinonin 100 µM 2.54169175758212 0.0081401608252358 no 66 0.00551587071414598 55 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2552 juarezic acid 87.02 µM 2.52491293927263 0.00850639460681004 no 67 0.00578634774374748 141 1549512 SGTC_1373 2887-0003 58.5 µM 2.51585613935402 0.00871002535946501 no 68 0.00593718202715542 123 776948 SGTC_2291 7917025 104.35 µM 2.51096748142169 0.00882170709730648 no 69 0.00602003937186848 165 2964612 SGTC_2502 avocadyne acetate 18.59 µM 2.49790774881333 0.00912623463864375 no 70 0.00624643498686819 148 3952079 SGTC_1277 0873-0036 22 µM 2.49282751566658 0.00924715940527718 no 71 0.0063365196304053 125 5965735 SGTC_1836 st055642 81 µM 2.48520154823963 0.00943131237161315 no 72 0.00647390526936279 142 8571 SGTC_619 1652-1634 108 µM 2.48379051653721 0.00946573558310361 no 73 0.0064996126477658 112 5400454 SGTC_1331 1472-0049 76.2 µM 2.47658084888327 0.00964334122849819 no 74 0.0066323789221972 138 24051409 SGTC_95 0471-0001 561.058 µM 2.45968496541768 0.0100710114825173 no 75 0.00695295104857881 132 4015405 SGTC_427 1354-0053 47.3 µM 2.44729169527042 0.0103951463231174 no 76 0.00719671490886911 135 6813657 SGTC_1678 st019265 80.2 µM 2.42311846591767 0.0110536215876304 no 77 0.00769395385235431 146 5367020 SGTC_180 1486-1293 102.781 µM 2.39904780954529 0.0117450568930198 no 78 0.00821888416317252 159 4140536 SGTC_604 1000-0114 314 µM 2.39504785635436 0.0118635216026498 no 79 0.00830909805365129 132 1572745 SGTC_1124 fisetin 1.16336 µM 2.39348275808746 0.0119101557543826 no 80 0.00834463285942483 155 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_923 1900-2434 73.3 µM 2.38402886483225 0.0121952418790425 no 81 0.00856212957493613 153 5910570 SGTC_1842 st055362 61.2 µM 2.38165747425706 0.0122676732025644 no 82 0.00861746003546683 129 676032 SGTC_1121 fusaric acid 630.51 nM 2.3759956222455 0.0124421168593051 no 83 0.00875083522682759 150 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2242 6630449 61.2675 µM 2.35952956653797 0.0129617030374186 no 84 0.00914906133810392 145 691249 YDR170C SEC7 SGTC_1554 st069299 38.7 µM 2.35148708625854 0.0132222321093158 no 85 0.00934926933171152 143 24207999 SGTC_2529 gangaleoidin 93.61 µM 2.34402899801427 0.0134678610563712 no 86 0.00953834407507783 107 4565183 SGTC_1381 2324-0066 62.1 µM 2.34066561627265 0.0135799152454749 no 87 0.00962469938929162 170 10885928 SGTC_1206 3978-0017 132 µM 2.3376928339549 0.0136796252317309 no 88 0.00970159409213239 144 3873677 SGTC_1256 0570-0116 285 µM 2.33599736194021 0.0137367753767495 no 89 0.00974568951340244 147 410638 SGTC_78 0336-0123 156.75 µM 2.33357271523638 0.0138188620155758 no 90 0.00980905333571245 124 6765896 SGTC_901 1112-0062 60.1 µM 2.32542834384978 0.01409769499812 no 91 0.0100245336771738 108 1908457 SGTC_799 1310-0557 151 µM 2.31304123575873 0.0145310745857273 no 92 0.0103601860425444 154 5354492 SGTC_1627 st003713 25.6 µM 2.29006521596129 0.0153653294027357 no 93 0.0110087682030512 272 16195070 YER133W GLC7 SGTC_1723 st034307 2.5525 µM 2.28336940355815 0.0156160621203364 no 94 0.0112043089799482 161 867466 SGTC_666 0272-0154 136 µM 2.28205727849148 0.0156656054693296 no 95 0.0112429793997041 213 6870312 SGTC_1826 st055655 41.6 µM 2.27937993645577 0.015767115252697 no 96 0.0113222449682613 173 676168 SGTC_880 0833-0487 87.2 µM 2.27716361988447 0.0158515718556042 no 97 0.0113882283601038 145 76075 SGTC_2100 5377183 190 µM 2.27543899483111 0.0159175598077309 no 98 0.0114398041879193 148 2844202 SGTC_1911 st060208 74.3 µM 2.27447608388402 0.0159545052557177 no 99 0.0114686887323773 168 688783 SGTC_1560 lithocholic acid 53.1 µM 2.26310344038238 0.0163964473449416 no 100 0.0118146567659849 70 9903 A bile acid which acts as a detergent. SGTC_2403 6032726 181.2 µM 2.24702630459291 0.0170390638372172 no 101 0.012319173030638 180 2881040 SGTC_1883 5-benzylidenerhodanine 20 µM 2.24375167987994 0.0171725597135479 no 102 0.0124241914712346 240 1273210 SGTC_2666 tannic acid 100 µM 2.24323155393008 0.0171938456056138 no 103 0.0124409432624067 187 16134267 A thiamine antagonist. SGTC_2404 5161160 200 µM 2.24101453464745 0.0172848290230459 no 104 0.0125125667691015 169 2831543 SGTC_13 0199-0087 65 µM 2.22990172730675 0.0177471049424058 no 105 0.0128769838520401 134 4589825 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.22805433062864 0.0178249674697642 no 106 0.0129384461060413 125 61125 An anti-inflammatory. SGTC_2979 9012552 45.46 µM 2.22308681174008 0.0180357809569747 no 107 0.0131049733834902 99 17100905 SGTC_2036 5160441 105 µM 2.19797231160794 0.0191344245445214 no 108 0.0139755395629617 232 134534 YIL048W NEO1 SGTC_124 0136-0217 7.121 µM 2.19118482692536 0.0194409337589849 no 109 0.014219210074799 214 3976905 SGTC_3294 9122953 26.2835 µM 2.18484358647603 0.019731050298535 no 110 0.0144501584983372 166 16459826 SGTC_689 0833-0039 98 µM 2.16867102734225 0.0204876416510491 no 111 0.0150538342526976 173 5374726 SGTC_1357 1503-1303 39.5 µM 2.1639608463798 0.020712564503693 no 112 0.0152336772294124 211 292895 SGTC_825 1988-2224 89.6 µM 2.16373462796605 0.0207234194182872 no 113 0.015242360896586 200 1180859 SGTC_2164 5685496 200 µM 2.15210995979481 0.0212877406159129 no 114 0.0156943474488513 161 759046 SGTC_333 3486-0131 40.1 µM 2.14742373436845 0.0215188816615626 no 115 0.0158797813993096 154 6744690 SGTC_2894 9048625 32.47 µM 2.14366779754382 0.0217056657297468 no 116 0.0160297571004022 157 4092861 SGTC_1348 1493-0373 93.8 µM 2.14315873913676 0.0217310864774957 no 117 0.0160501770847203 171 3010129 SGTC_2244 6635614 200 µM 2.14281078889901 0.0217484764655339 no 118 0.0160641473213295 85 836499 SGTC_2005 4024620 188 µM 2.12091229266659 0.0228668257771765 no 119 0.0169645919983854 180 236743 SGTC_660 4031-1742 102 µM 2.10397765031642 0.0237645498382358 no 120 0.0176901983166626 233 6738706 SGTC_551 k048-0028 34.9 µM 2.0928635066483 0.0243696837537308 no 121 0.0181806703700592 201 6836383 SGTC_2892 9047358 58.44 µM 2.08928216558654 0.0245674128581783 no 122 0.018341165415681 131 6466771 SGTC_1310 1188-0297 994 nM 2.08848625315126 0.0246115382869797 no 123 0.0183769970846111 198 1588352 SGTC_3222 9128301 49.47 µM 2.08405298224959 0.0248585376427768 no 124 0.0185776740938669 193 4911358 SGTC_1943 st076331 65.2 µM 2.08339776463433 0.0248952187792513 no 125 0.0186074909306922 180 24208415 SGTC_2023 5144124 124 µM 2.06994134581512 0.0256586471019763 no 126 0.0192289187377509 195 2830192 SGTC_1623 st003709 20.3 µM 2.06830809071072 0.02575262708469 no 127 0.0193055307268884 301 16192618 SGTC_2569 tetrandrine 100 µM 2.06230143814162 0.0261007406401688 no 128 0.0195895231010901 185 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_573 3702-0553 84.7 µM 2.05905922296063 0.0262902718666625 no 129 0.0197442827481648 177 1222756 SGTC_1711 st032263 62.8 µM 2.05785794872719 0.0263607866345493 no 130 0.0198018857061464 177 3958979 SGTC_1545 lovastatin 49.4 µM 2.05295887095979 0.0266500013645299 no 131 0.0200382832939594 237 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_912 3474-0017 2.18 µM 2.04813672140767 0.0269372582634943 no 132 0.0202733023293183 213 3360550 SGTC_2018 5133068 143 µM 2.04697902617497 0.0270066059463492 no 133 0.020330071957131 221 785362 SGTC_1002 4049-0206 172 µM 2.03675991390319 0.0276252326128743 no 134 0.0208370535964674 253 4662749 SGTC_2457 5731572 11.68 µM 2.0228392673723 0.0284868988969938 no 135 0.0215448608734401 154 2865357 SGTC_403 arphamenine a 50 µM 2.01479739812922 0.0289947882688474 no 136 0.0219629408945411 228 5487158 An arginine aminopeptidase inhibitor. SGTC_542 3381-0244 89.3 µM 2.01378618243476 0.0290591816120893 no 137 0.0220159935241726 245 1112843 SGTC_3255 9139072 49.47 µM 2.00866026875178 0.0293874258267597 no 138 0.0222865874955025 196 17646060 SGTC_3000 9075062 71.4286 µM 2.0055242491486 0.029589758426971 no 139 0.0224535155106154 208 17057871 SGTC_2582 agaric acid 100 µM 2.00451706868001 0.0296549854062638 no 140 0.0225073501849465 662 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.00307413725157 0.0297486403562947 no 141 0.0225846657548157 130 4620898 SGTC_2674 ligustilide 100 µM 2.00167978126506 0.029839375487912 no 142 0.0226595911506568 157 5319022 A signalling regulator. SGTC_1214 0358-0031 63.7 µM 1.99628365372804 0.0301926844480242 no 143 0.0229515281433977 227 4301366 SGTC_1827 berberine 7.24 µM 1.98150658090248 0.03117799233814 no 144 0.023767246047856 215 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_417 st075190 100 µM 1.97678616730029 0.0314982909147483 no 145 0.0240329029653137 234 222757 SGTC_191 3914-0123 66.505 µM 1.97677696054848 0.03149891827674 no 146 0.0240334235336543 104 3144412 SGTC_1265 0819-1001 68.8 µM 1.96707660031367 0.032165677699316 no 147 0.0245871902339064 222 3106768 SGTC_1287 0971-0001 34.6 µM 1.96517266738958 0.0322979038487883 no 148 0.0246971281544175 278 4665869 SGTC_1126 isoteolin 1.0172 µM 1.96484748693661 0.0323205320788047 no 149 0.0247159460713795 243 133323 SGTC_2072 5231554 129 µM 1.96360830588378 0.0324068825330243 no 150 0.0247877667210299 188 789545 SGTC_1819 st053448 58.6 µM 1.96254716132459 0.0324809779921469 no 151 0.0248494077611237 216 2857616 SGTC_2471 5466956 24.79 µM 1.96036995930431 0.0326334408267487 no 152 0.0249762822145396 174 724419 SGTC_257 daunorubicin 18.5 µM 1.96027501316707 0.0326401030232759 no 153 0.0249818274500763 177 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2280 7785178 200 µM 1.95949824192628 0.0326946497740658 no 154 0.0250272327862691 198 2954328 SGTC_1616 st002734 56.1 µM 1.95392812174853 0.0330880028863958 no 155 0.0253548591402163 269 4026101 SGTC_177 1327-0068 8.361 µM 1.95357370334281 0.0331131627353953 no 156 0.0253758265290847 273 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2070 5230947 200 µM 1.95079646238288 0.0333108627634134 no 157 0.0255406314249136 210 2835538 SGTC_3204 9114183 49.47 µM 1.95046405784093 0.0333345902373191 no 158 0.0255604166410863 240 17027248 SGTC_2153 5569715 200 µM 1.95000292578168 0.0333675294960682 no 159 0.0255878851610365 193 2054701 SGTC_1272 0839-0021 27 µM 1.94824146868022 0.0334935994705369 no 160 0.0256930385154505 240 5027250 SGTC_1904 st060225 78 µM 1.94670172483173 0.0336041220661261 no 161 0.0257852523604522 208 66595 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.93566131611721 0.0344054227602989 no 162 0.0264545976255477 276 23847180 SGTC_840 0245-0196 390 µM 1.93326085955673 0.0345817071467753 no 163 0.0266020354424788 262 3827528 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.9330231487828 0.0345992044177683 no 164 0.0266166730952838 114 279621 SGTC_444 curcumin 90.4 µM 1.93088119609772 0.0347571961733233 no 165 0.0267488730457167 251 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2016 5121758 140 µM 1.9278695809311 0.0349803363061721 no 166 0.0269356751171497 308 2795203 SGTC_1965 Pectolinarigenin 58.4 µM 1.92767340128496 0.0349949125759648 no 167 0.0269478812779948 214 5320438 An anti-inflammatory. SGTC_995 3931-2021 34.6 µM 1.92643149651516 0.0350873025783455 no 168 0.0270252589029431 239 730143 SGTC_2495 cafestol 54.53 µM 1.92495954883807 0.0351970654452055 no 169 0.0271172095365185 245 16667697 An anti-infammatory. SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.9238785224039 0.0352778566693627 no 170 0.0271849059740329 268 1273210 SGTC_2889 9059656 51.95 µM 1.92263831628951 0.0353707315889072 no 171 0.0272627442299821 229 3949838 SGTC_2414 st077232 92.9 µM 1.91913907289591 0.0356338598372502 no 172 0.0274833678563272 257 729801 SGTC_2756 carbadox 75.1 µM 1.9166053287806 0.0358253864012397 no 173 0.0276440452629056 316 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.91639274013311 0.0358414943288789 no 174 0.0276575621022006 196 364106 SGTC_760 0568-0725 82.9 µM 1.91508158416195 0.0359409723534282 no 175 0.0277410499986512 211 3916171 SGTC_1010 4112-3296 15.2 µM 1.91440041726652 0.0359927420129637 no 176 0.0277845061458225 258 704384 SGTC_1728 st035614 33.7865 µM 1.91080999008467 0.0362666299811963 no 177 0.028014501711373 330 15945546 SGTC_2270 7924575 90.91 µM 1.9037366520462 0.0368111958010586 no 178 0.0284722452159499 242 1262135 SGTC_860 0443-0016 25.1 µM 1.89716501328065 0.0373231111059788 no 179 0.0289030814259466 250 5337942 SGTC_1427 4048-4900 550 nM 1.89439229643526 0.0375408367469414 no 180 0.029086479099149 235 24132586 SGTC_223 busulfan 5 mM 1.89156602731954 0.0377638337841293 no 181 0.0292744129530854 164 2478 A DNA alkylator. SGTC_2051 5263410 176 µM 1.88761019801783 0.038077769361169 no 182 0.0295391500026787 254 227584 SGTC_2360 9040895 200 µM 1.88654321896289 0.0381628086408139 no 183 0.029610895059491 241 4914414 SGTC_3221 9128209 49.47 µM 1.88149595215063 0.0385671824634439 no 184 0.0299522426974299 221 16460723 SGTC_3316 9136639 10.545 µM 1.87034329541118 0.0394730908270669 no 185 0.0307180804420129 235 4903665 SGTC_44 0929-0055 61.211 µM 1.86135587838757 0.0402156508838607 no 186 0.0313469684839683 250 1379590 SGTC_2800 7887935 81.82 µM 1.85889168162551 0.0404212184451301 no 187 0.0315212467107991 263 2961002 SGTC_71 0417-1750 47.813 µM 1.85555912348527 0.0407005825256928 no 188 0.0317582123149839 305 6811472 SGTC_2104 5389443 200 µM 1.85243334397446 0.0409640347171566 no 189 0.0319818104535062 295 2244536 SGTC_888 0916-0002 6.97 µM 1.8481654398119 0.0413259812418643 no 190 0.0322892066763743 251 2802138 YIL048W NEO1 SGTC_2765 myclobutanil 7.74 µM 1.84269979785956 0.0417932846707947 no 191 0.0326864267805408 290 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1612 st002233 45.4 µM 1.83976803484599 0.0420457034681753 no 192 0.0329011501159869 262 1035021 SGTC_2120 5538279 151.968 µM 1.83614196017445 0.0423596065153096 no 193 0.0331683319539494 273 2058197 SGTC_1594 piperine 70.1 µM 1.8352650508335 0.0424358030237056 no 194 0.0332332133855961 296 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_961 1252-1571 372 µM 1.83421195807557 0.0425274549472775 no 195 0.0333112685243252 287 6813498 SGTC_3138 9097216 49.47 µM 1.82095488169173 0.0436949813069844 no 196 0.0343068577812424 257 25237486 SGTC_599 1935-0052 86.5 µM 1.81600493602114 0.0441374904244691 no 197 0.0346848074791002 296 9557311 SGTC_3130 9127414 49.47 µM 1.80856045512469 0.0448097984711786 no 198 0.0352596583631137 249 1494646 SGTC_841 0251-0215 91.2 µM 1.80664471632043 0.0449841354766721 no 199 0.0354088463078804 356 3888614 SGTC_151 3013-0144 2.285 µM 1.8031879451972 0.0453000913109252 no 200 0.0356793515131744 293 906558 YHR107C CDC12 SGTC_2197 6588183 93.1375 µM 1.80129456879081 0.0454739049542963 no 201 0.0358282317199232 210 884136 SGTC_135 0933-0004 26.348 µM 1.79736360795 0.0458364832192439 no 202 0.0361389570960387 294 21230617 YGL099W LSG1 SGTC_2710 st078562 53.7235 µM 1.79429166328832 0.0461214429610449 no 203 0.0363833140234235 266 17250908 SGTC_3268 9137683 49.47 µM 1.79249893934236 0.0462883960143385 no 204 0.0365265394659247 203 1953228 SGTC_588 3970-1144 52.9 µM 1.79225971677097 0.046310711019073 no 205 0.0365456864272185 301 1888707 SGTC_1181 1222-0449 220 µM 1.78959890637615 0.0465594977759021 no 206 0.0367592072233166 278 658318 SGTC_70 0141-0289 43.283 µM 1.78612725518871 0.0468857098777608 no 207 0.0370393280344055 550 352408 SGTC_1186 1319-0216 26 µM 1.7846136180738 0.0470285107607085 no 208 0.0371620054897201 295 4565136 SGTC_2368 9071271 200 µM 1.78006756470819 0.0474594960507394 no 209 0.0375324520111543 311 27209959 SGTC_688 0527-0193 473 µM 1.77381688292044 0.0480572477850397 no 210 0.0380467222935977 250 4007154 SGTC_2091 4-phenylthiadiazole 200 µM 1.77114546035464 0.0483145464523715 no 211 0.0382682579951716 308 270010 SGTC_2031 5180455 200 µM 1.76537246362768 0.0488743375661837 no 212 0.0387505940738993 247 29949 SGTC_400 oxethazaine 37.5 µM 1.76499958338235 0.0489106721597586 no 213 0.0387819178660139 283 4621 A local anesthetic. SGTC_2198 6589944 200 µM 1.7624796123351 0.0491567920003419 no 214 0.0389941490204999 229 5290268 SGTC_1308 1187-1617 41.4 µM 1.75794889986339 0.0496017834331197 no 215 0.03937810220603 344 2882570 SGTC_1006 4099-6547 255 µM 1.75778618260571 0.0496178245802544 no 216 0.0393919486216898 298 3146833 SGTC_2701 st077767 14.721 µM 1.75685007828079 0.049710188933096 no 217 0.0394716833290281 355 5721188 SGTC_3008 9078912 71.4286 µM 1.75579818340513 0.0498141418354168 no 218 0.0395614373471781 266 16648731 SGTC_2587 piperic acid 92.2 µM 1.75463120079818 0.0499296710410358 no 219 0.0396612054982936 291 5370536 SGTC_2621 lithochol-11-enic acid 100 µM 1.7530758352116 0.050083981553939 no 220 0.0397944954036597 348 6708711 SGTC_3005 9076496 71.4286 µM 1.74846891896428 0.0505432736101469 no 221 0.0401914315075037 251 21368410 SGTC_3036 9090181 49.47 µM 1.74432203755578 0.0509595656308121 no 222 0.0405514754963602 243 25236586 SGTC_2319 6033012 152.6 µM 1.73950186107463 0.0514468725778524 no 223 0.0409732625764967 254 847246 SGTC_898 1000-0849 28.3 µM 1.73639781760094 0.0517626398844823 no 224 0.0412467589447008 262 6751807 SGTC_722 3534-0461 190 µM 1.73398033495256 0.0520096304102303 no 225 0.0414607862156072 323 658262 SGTC_2883 9059145 45.46 µM 1.73127628404787 0.0522870075965799 no 226 0.0417012496192043 266 16476510 SGTC_48 0382-0018 55 µM 1.72824453783744 0.0525993947086299 no 227 0.0419721959418007 263 762596 SGTC_1039 k821-0043 94 µM 1.71813984808446 0.0536512750272477 no 228 0.042885555026584 317 15992768 SGTC_2425 5628681 7.85 µM 1.71724526981217 0.0537451962571429 no 229 0.0429671836576531 372 5714958 SGTC_2081 5214970 32.255 µM 1.71571530800575 0.053906127758305 no 230 0.0431070807946 302 2063512 SGTC_804 1595-0054 20.9 µM 1.71205693460725 0.0542924866090628 no 231 0.0434430883445375 310 761523 Stimulates phospholipase C. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.7056235558208 0.0549772230129347 no 232 0.0440390953598811 366 23665772 A membrane-active detergent. SGTC_2465 5809242 33.21 µM 1.68834640983126 0.0568499117879473 no 233 0.0456723756113843 241 2731748 SGTC_3348 9149464 3.537 µM 1.68346005777453 0.0573885626807867 no 234 0.0461430326844194 321 1951442 SGTC_574 1315-0397 40 µM 1.6827048415776 0.057472171638537 no 235 0.046216122008154 431 6794277 SGTC_282 k297-0036 65.7 µM 1.67748550657033 0.058052619319259 no 236 0.0467237906313752 278 5061378 SGTC_2265 7929201 200 µM 1.67685132666714 0.0581234599063446 no 237 0.0467857790283203 337 1265108 SGTC_1683 st010134 710 nM 1.67470451311455 0.0583637723423919 no 238 0.0469961107578635 356 3818134 SGTC_2211 7117706 200 µM 1.67351269958658 0.0584975193765803 no 239 0.0471132043045517 292 822771 SGTC_1822 st052468 42 µM 1.67229267031732 0.0586346819812786 no 240 0.0472333121450836 294 2873678 SGTC_2432 5630864 12.22 µM 1.66974108166754 0.0589223621274089 no 241 0.0474853009589623 332 5714970 SGTC_2849 9019321 12.99 µM 1.66898800078508 0.0590074799363068 no 242 0.0475598789292337 332 16489627 SGTC_360 0957-0399 1.01 µM 1.66390286392755 0.0595847604450116 no 243 0.0480659213058466 366 6752301 YPR165W RHO1 SGTC_2234 tolnaftate 200 µM 1.66292170632841 0.0596966521875031 no 244 0.0481640543764298 240 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1747 st037496 66.6 µM 1.6623466130017 0.0597623126304501 no 245 0.0482216483335799 377 723305 SGTC_2773 thioridazine 9.09 µM 1.65885565837875 0.0601621021949746 no 246 0.0485724408060433 324 5452 An antipsychotic. SGTC_2984 9022109 38.96 µM 1.65779104019437 0.0602844396613035 no 247 0.0486798252023338 247 6459207 SGTC_2943 9068529 45.32 µM 1.65525748528128 0.0605763587153478 no 248 0.0489361394742436 384 3270634 SGTC_1692 fluoroquinolonic acid 71 µM 1.65485467278867 0.0606228729418591 no 249 0.0489769903124805 294 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1526 st051518 75 µM 1.65229391422353 0.0609192267318563 no 250 0.0492373246651517 311 673993 SGTC_1957 st077035 62.4 µM 1.65142747611197 0.0610197547205245 no 251 0.0493256591281476 316 705593 SGTC_1539 benzyladenosine 56 µM 1.64664814722153 0.0615766058624232 no 252 0.0498151939843224 311 92208 A nucleotide analog. SGTC_949 1165-0505 146 µM 1.64435176530031 0.0618455704835386 no 253 0.0500517811900591 388 6244267 SGTC_2135 5326629 150.42 µM 1.63577387588453 0.0628583760574685 no 254 0.0509434607168097 340 5020077 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.63352920469141 0.0631255299217455 no 255 0.0511788718094746 376 688761 SGTC_2132 5317594 122.667 µM 1.63156389360706 0.063360160480628 no 256 0.051385694827389 299 794577 SGTC_500 h-89 112 µM 1.62751398164959 0.0638458035165504 no 257 0.0518139907841827 372 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1718 roemerine 11.9335 µM 1.61871956602152 0.0649103467839242 no 258 0.0527538075390617 425 235224 An aporphine alkaloid with mutagenic activity. SGTC_2813 7971799 71.43 µM 1.61745558238652 0.0650644750459291 no 259 0.0528899880787713 336 2234054 SGTC_129 0088-0017 176.636 µM 1.61607616471892 0.065233003126204 no 260 0.053038923434689 384 182446 SGTC_1648 st011736 69.8 µM 1.61232062091172 0.0656935468647252 no 261 0.0534460941561597 357 2855514 SGTC_970 1315-0089 19.5 µM 1.60589484497983 0.0664873832314875 no 262 0.0541485081906784 341 6811083 YLR033W RSC58 SGTC_3053 9095903 49.47 µM 1.60579958878736 0.0664992067354777 no 263 0.0541589755193389 317 17174018 SGTC_810 3825-7150 143 µM 1.60529179393906 0.0665622633282351 no 264 0.0542148021230228 361 22330411 YGL099W LSG1 SGTC_690 glyoxal 20.3 µM 1.59631627749076 0.0676844732780889 no 265 0.0552090988558728 431 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1527 coumarin 137 µM 1.59577697694274 0.0677523647833967 no 266 0.0552692976358488 360 323 A hepatotoxic, DNA x-linker. SGTC_413 propylparaben 100 µM 1.59395625808762 0.067981960181968 no 267 0.0554729162271949 326 7175 A pharmaceutical preservative. SGTC_3196 9111891 49.47 µM 1.58954197108134 0.0685411020773596 no 268 0.0559690431052895 326 18891510 SGTC_3185 9108267 49.47 µM 1.5894361010942 0.0685545556781257 no 269 0.055980984794519 387 4910486 SGTC_1456 k015-0012 13 µM 1.58572391603378 0.0690275766593356 no 270 0.0564009757369014 416 2989616 SGTC_1659 st012954 42.1 µM 1.58145299379045 0.069574901491488 no 271 0.0568872493621667 332 24207262 SGTC_2683 piperine 63.03 µM 1.57889362198523 0.0699044862397902 no 272 0.0571802295981189 326 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1353 1498-1206 8.11 µM 1.57519281247495 0.070383183337711 no 273 0.0576059728724406 457 6756808 SGTC_1905 st060207 84.5 µM 1.57047441881401 0.0709971546518294 no 274 0.058152390591946 360 1948547 SGTC_656 4090-1979 187 µM 1.56870446409535 0.0712285244136386 no 275 0.0583584089729622 424 22330961 SGTC_2105 5350118 200 µM 1.56149900975714 0.0721764054197379 no 276 0.0592030286538588 375 2133313 SGTC_316 k060-0003 58.6 µM 1.56039424064208 0.0723225892295274 no 277 0.0593333725096419 372 6152314 SGTC_40 0327-0103 19.753 µM 1.55266177382258 0.0733521130848353 no 278 0.0602519796144011 387 409036 SGTC_160 3453-0671 289.699 µM 1.54640696263712 0.0741930685040639 no 279 0.0610031568382703 420 5322268 SGTC_605 1315-0399 119 µM 1.54617661502797 0.0742241785989387 no 280 0.0610309597800325 430 24020461 SGTC_2006 4011487 200 µM 1.5409739496846 0.0749294924458034 no 281 0.0616615631172835 457 45595294 SGTC_1856 st057054 55.7 µM 1.53937394009571 0.0751474269148504 no 282 0.0618565161407353 405 1266018 SGTC_3092 9117248 49.47 µM 1.53797547909094 0.0753383043552611 no 283 0.0620273052089539 360 17141857 SGTC_349 k015-0014 24 µM 1.53380537920057 0.0759096799604282 no 284 0.0625387696250992 386 2196908 SGTC_1645 Cervolide 78 µM 1.52993162897662 0.0764434014401197 no 285 0.0630168266951474 365 23173 A fragrance. SGTC_3325 9138760 55.175 µM 1.52882042512916 0.076597027720102 no 286 0.0631544837212444 408 43844959 SGTC_2165 5727197 32.143 µM 1.52774750395593 0.0767455840565556 no 287 0.0632876203478633 410 1361712 SGTC_595 3909-8003 73.7 µM 1.52557520403555 0.077047030713937 no 288 0.0635578456436657 404 699517 SGTC_2865 9030313 51.95 µM 1.52535467985938 0.0770776827503785 no 289 0.0635853280809463 378 42562754 SGTC_424 splitomicin 100 mM 1.52109819862547 0.0776711349536779 no 290 0.0641175982342059 396 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2231 micatex 6.853 µM 1.51794747087382 0.0781126489270636 no 291 0.0645138207345256 355 20737 An antifungal of unknown mechanism. SGTC_2259 7964009 200 µM 1.51705482922909 0.0782380809533853 no 292 0.0646264207492516 374 313134 SGTC_1377 2944-0135 198 µM 1.51465881930769 0.07857551823396 no 293 0.0649294141184518 446 1894137 SGTC_2377 9073351 62.6 µM 1.51429065558353 0.0786274654642221 no 294 0.0649760687567862 405 7337946 YHR072W ERG7 SGTC_201 4262-0159 12.803 µM 1.51200354605802 0.0789507556971628 no 295 0.0652664802202357 342 1341029 SGTC_3169 9102970 49.47 µM 1.50667984130039 0.0797071767467068 no 296 0.0659463705633054 363 17027839 SGTC_3082 9117008 49.47 µM 1.50103078901344 0.0805158066127871 no 297 0.0666737991364974 415 41448529 SGTC_1775 st081588 35.1725 µM 1.50098057904649 0.0805230215678425 no 298 0.0666802924047515 459 1426443 YGL099W LSG1 SGTC_2614 arthonioic acid 13.39 µM 1.50057403189806 0.0805814586222654 no 299 0.0667328860407426 386 6710684 SGTC_2464 5717415 7.67 µM 1.49801562131503 0.0809499396448027 no 300 0.067064595942561 441 5285744 SGTC_952 1185-0122 232 µM 1.49727496069631 0.0810568520569562 no 301 0.067160863685878 434 678600 SGTC_764 1951-2361 146 µM 1.49037325781503 0.0820582230521039 no 302 0.0680630599921479 447 5438930 SGTC_1425 4048-4433 7.33 µM 1.48994285185673 0.082120978205109 no 303 0.068119631463272 487 23734946 SGTC_1685 st024049 53.0905 µM 1.48913178725541 0.0822393333706379 no 304 0.0682263343800667 373 1941139 SGTC_633 0437-0093 97.7 µM 1.48893933805251 0.0822674355034872 no 305 0.0682516717468266 401 2831118 SGTC_1813 st051246 8.6015 µM 1.47898121325061 0.0837314458485917 no 306 0.0695726679679466 378 5291959 SGTC_2528 xanthyletin 44.79 µM 1.47589684779537 0.0841888455501267 no 307 0.0699857929302093 400 65188 An natural product with antifungal activity of unknown mechanism. SGTC_31 0508-1974 57.237 µM 1.47585408974142 0.0841951995612443 no 308 0.069991533249541 435 6810525 SGTC_464 bw-b 70c 158 µM 1.47390097590184 0.0844858236765952 no 309 0.0702541274834571 473 5353454 SGTC_2170 morpholine 200 µM 1.47360375552761 0.0845301160861655 no 310 0.0702941548073339 393 121171 Reacts with secondary amines. SGTC_984 1492-0255 2.91 µM 1.4671151361243 0.0855014100065931 no 311 0.0711723686455673 410 1585198 SGTC_2712 st079126 47.7 µM 1.46602565520334 0.0856653127653247 no 312 0.0713206488568964 408 3152970 SGTC_2437 5741531 144.16 µM 1.46361895192771 0.0860282135618416 no 313 0.071649045681218 470 2262990 SGTC_2940 9060638 45.86 µM 1.46151952584312 0.086345719087445 no 314 0.0719364605132759 453 4027022 SGTC_2990 9074105 71.4286 µM 1.46128282669153 0.0863815710472411 no 315 0.071968920387999 399 6502001 SGTC_2364 9055074 200 µM 1.45559722241087 0.0872460971286739 no 316 0.0727519981677566 415 6470630 SGTC_1992 st073643 23.3 µM 1.4555777969051 0.087249061912365 no 317 0.0727546847797041 422 3161292 SGTC_3023 9089636 49.47 µM 1.45335506384306 0.0875887995908351 no 318 0.0730625980719256 436 17249241 SGTC_2846 9008642 19.48 µM 1.45276402615044 0.087679303745432 no 319 0.0731446416261551 421 2992898 SGTC_657 3534-0529 86.7 µM 1.45039148475893 0.0880433074296304 no 320 0.0734746901590695 439 1049549 SGTC_1304 1165-0502 251 µM 1.44689349790281 0.0885820344479873 no 321 0.0739633772511011 521 767425 SGTC_1647 st011722 22.4 µM 1.44542064579912 0.0888096024586695 no 322 0.0741698838636275 419 2854783 SGTC_1940 st075990 51.1 µM 1.44302126821801 0.08918125820621 no 323 0.0745072400423632 506 1084979 SGTC_2066 5222451 176 µM 1.43977633071402 0.0896857277858165 no 324 0.0749653448794326 528 2281147 SGTC_643 k048-0106 28.4 µM 1.43589677332103 0.0902916385164636 no 325 0.0755158583982191 451 6763920 SGTC_3115 9123671 49.47 µM 1.43458575524414 0.0904970795673232 no 326 0.0757025880898201 426 3286988 SGTC_2684 capsaicin 100 µM 1.43409804150934 0.0905735944906751 no 327 0.0757721433648938 433 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2352 9027995 87.8 µM 1.42985406449887 0.0912414385646735 no 328 0.0763794541305263 396 2997347 SGTC_2440 5628896 157.78 µM 1.42506215428869 0.091999887838945 no 329 0.0770696176365083 429 5522048 SGTC_1887 st057648 70.8 µM 1.41855251725926 0.0930376788222783 no 330 0.0780147587078782 466 688672 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.41562025203225 0.0935079682927351 no 331 0.0784433592875531 477 5377381 SGTC_830 4076-0286 57.8 µM 1.41213946776932 0.0940685079250498 no 332 0.0789544498254134 636 6866659 SGTC_1909 st060837 51.5 µM 1.40776051535488 0.0947772034824785 no 333 0.0796009979064713 494 678937 SGTC_17 0960-0276 49.807 µM 1.40581374540414 0.0950935317452983 no 334 0.0798897196643777 513 6821114 SGTC_483 fpl-64176 144 µM 1.40500554838374 0.0952250828592488 no 335 0.0800098141990376 388 3423 SGTC_981 1488-1094 54.9 µM 1.40384211087947 0.0954146920864708 no 336 0.0801829355229078 416 3449522 SGTC_2271 7849410 118.62 µM 1.40297335613966 0.0955564570315579 no 337 0.0803123921263999 459 972430 SGTC_1044 1222-0021 1.78 µM 1.40165780561818 0.0957714259022374 no 338 0.0805087281400615 484 4306703 SGTC_2556 citropten 84.59 µM 1.39773001953382 0.0964153662333307 no 339 0.0810970779981513 534 2775 A potential DNA crosslinker. SGTC_3031 9088762 49.47 µM 1.39511384250503 0.0968460367709417 no 340 0.0814907562731625 485 205253 SGTC_453 enantio-paf c16 10 µM 1.39159158532212 0.0974280934273523 no 341 0.0820230542125332 672 13871343 A lipid and platelet activating factor SGTC_200 k038-0079 37.545 µM 1.38925943671553 0.0978148928513632 no 342 0.0823769368755708 470 3436683 SGTC_2383 9036125 200 µM 1.38872009034628 0.0979045064040329 no 343 0.082458941297809 423 79580 SGTC_504 lovastatin 124 µM 1.38844943383764 0.0979494992295484 no 344 0.0825001161699169 413 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2661 dactinomycin 12.96 µM 1.38810735828699 0.0980063861391134 no 345 0.0825521781347125 523 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1570 verbenone 133 µM 1.38708048758415 0.0981772993877423 no 346 0.082708610596703 490 29025 A natural terpanoid with antifungal properties. SGTC_3227 9130768 49.47 µM 1.38310350139134 0.0988412928070465 no 347 0.0833165661212859 449 17720899 SGTC_2950 9072895 21.46 µM 1.37497719156196 0.100208258212024 no 348 0.084569257994429 527 17332245 SGTC_3304 9125678 46.087 µM 1.37497530279182 0.10020857752716 no 349 0.0845695507865296 520 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3145 9085516 49.47 µM 1.3749548854227 0.10021202933128 no 350 0.0845727158810762 480 25236195 SGTC_445 e6 berbamine 66 µM 1.37461614982455 0.100269309361846 no 351 0.0846252395401936 636 6610268 A calcium/calmodulin antagonist. SGTC_2939 9044578 71.43 µM 1.37373654270294 0.10041816210223 no 352 0.084761743897419 487 2653634 SGTC_2381 9035592 200 µM 1.37329901740644 0.100492262952107 no 353 0.08482970397596 422 4749657 SGTC_3301 9125354 19.7965 µM 1.37228617382156 0.100663954825785 no 354 0.0849871840338743 442 41905162 SGTC_1896 st058441 89 µM 1.36812029356599 0.101372382620872 no 355 0.0856372127422343 456 688759 SGTC_54 0159-0055 9 µM 1.3637749636533 0.102115189391764 no 356 0.0863192011429871 502 3319099 SGTC_1148 3909-7663 27.7 µM 1.36216265271238 0.102391808603924 no 357 0.0865732796671559 507 4084526 SGTC_2028 5153890 36.43 µM 1.36116965961585 0.102562444280543 no 358 0.0867300399618685 498 2830968 YPR165W RHO1 SGTC_1327 1436-0082 2.18 µM 1.35858875406137 0.103006913117217 no 359 0.0871384703863758 488 15992205 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.35488065633894 0.103647947309555 no 360 0.0877277917826533 493 75037 A free radical scavenger. SGTC_626 0214-0009 33 µM 1.35233365662886 0.104089931466842 no 361 0.0881343011147298 527 3437874 SGTC_449 xestospongin c 11.1929 µM 1.34796614140707 0.104851009796216 no 362 0.0888346364517173 544 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_441 propafenone 146 µM 1.34645082618157 0.105116006130318 no 363 0.0890785844208501 457 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2359 9039622 200 µM 1.34363687210258 0.105609391859184 no 364 0.0895329200401435 540 6463596 SGTC_2219 9098279 200 µM 1.34354076208903 0.105626272869239 no 365 0.0895484681568961 487 902349 SGTC_374 0880-0231 82.3 µM 1.33774353017161 0.106648124576397 no 366 0.0904900278312557 533 6833587 SGTC_909 3448-9333 149 µM 1.33344443244857 0.107410501220263 no 367 0.0911929997012388 496 3344074 SGTC_2796 7949634 45.45 µM 1.33121741255145 0.10780696880719 no 368 0.0915587417811017 503 2971588 SGTC_2470 5664817 21.68 µM 1.33051067142554 0.107933007211662 no 369 0.0916750363517047 493 2859561 SGTC_1857 st056007 79.3 µM 1.32733343579012 0.108500938142152 no 370 0.092199204054907 486 619834 SGTC_2445 5742597 35.57 µM 1.32097120819452 0.109644642511745 no 371 0.0932554822769392 509 1774255 SGTC_1395 3486-0190 4.35 µM 1.31819939151914 0.110145615119903 no 372 0.0937184545866259 570 6748079 SGTC_1378 2093-0007 380 nM 1.31544785075899 0.110644544975397 no 373 0.0941797163895104 539 3618014 SGTC_1118 chelidonine 707.474 nM 1.31441863238137 0.110831586135178 no 374 0.0943526818147731 576 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_607 4491-0986 66.8 µM 1.31364071765078 0.110973107806523 no 375 0.0944835697379961 550 698981 YDR232W HEM1 SGTC_499 genistein 192 µM 1.31268049414976 0.111147974326902 no 376 0.0946453165424493 473 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1949 st076024 69.1 µM 1.3091501323327 0.111792585376549 no 377 0.0952417501924112 540 2921930 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.30854719375004 0.111902943113241 no 378 0.0953438891693396 594 66535 A nucleotide analog. SGTC_2131 toluylene red 5.2905 µM 1.30828797044245 0.11195041350588 no 379 0.0953878268844734 538 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1473 k844-0725 134 µM 1.30773155383704 0.112052356184312 no 380 0.095482188465627 607 54682906 SGTC_127 0180-0333 59.125 µM 1.30126880514435 0.11324127915799 no 381 0.0965832305165154 641 771601 SGTC_792 4534-1957 155 µM 1.30117603222745 0.113258411449027 no 382 0.0965991036240775 541 1717904 SGTC_1037 k284-1091 78.7 µM 1.29763351611726 0.113913988567908 no 383 0.0972066496665699 484 3334711 SGTC_2513 baicalein 25.65 µM 1.29483461383691 0.114433861475332 no 384 0.0976886442565051 549 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_612 0302-0167 22.4 µM 1.28940263253906 0.115447622005548 no 385 0.0986290733448431 627 235821 SGTC_570 0987-0065 62.6 µM 1.28810615793798 0.11569052114472 no 386 0.0988545060257639 443 3104428 SGTC_3276 9139060 49.47 µM 1.28808927113011 0.115693687341456 no 387 0.0988574448110367 491 4870619 SGTC_1574 spiramycin 23.7 µM 1.28687598798381 0.115921333295792 no 388 0.0990687579395065 567 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2679 rapamycin 1 nM 1.28581466955904 0.116120727030678 no 389 0.0992538746615854 655 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1471 k673-0312 37 µM 1.28532592842733 0.116212630411162 no 390 0.099339206611417 533 24099884 SGTC_2607 solasodine 47.35 µM 1.28406171378706 0.116450594026635 no 391 0.0995601814348139 567 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1431 4049-0260 9.09 µM 1.28332515892837 0.1165893952815 no 392 0.0996890909571384 548 3854841 SGTC_2334 9017922 200 µM 1.28244056675713 0.1167562486791 no 393 0.0998440706327609 557 3163164 SGTC_2102 5377816 72.7585 µM 1.27512122128177 0.118143334444013 no 394 0.101133169607903 592 1379702 SGTC_336 4111-0029 111 µM 1.27116336141376 0.118898222678992 no 395 0.101835268977278 503 3131175 SGTC_2486 5283202 22.39 µM 1.27048481402946 0.119027984300525 no 396 0.101955994415456 544 1377751 SGTC_2040 5100729 123 µM 1.26495618185004 0.120088976259498 no 397 0.10294351794905 595 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2247 cerulenin 830 nM 1.26435794619379 0.120204181184412 no 398 0.103050789929343 571 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_655 k060-0012 42 µM 1.25999159544095 0.121047387510135 no 399 0.10383619706942 580 5994525 SGTC_3113 9123498 49.47 µM 1.2563996179823 0.121744164009862 no 400 0.104485560043097 564 8897275 SGTC_555 4296-0685 37 µM 1.25554987978973 0.121909408720759 no 401 0.104639606387149 596 2908540 YHR072W ERG7 SGTC_685 1278-0033 54.9 µM 1.25183988915499 0.122632718994241 no 402 0.105314105927573 604 3590572 SGTC_926 2268-1401 59.4 µM 1.24842095379687 0.123301945097666 no 403 0.105938469713251 580 2931578 SGTC_982 1491-0518 27.5 µM 1.24812214186719 0.123360556230078 no 404 0.105993165403533 529 3091256 SGTC_2922 7999257 32.47 µM 1.2450714844887 0.123960051226935 no 405 0.10655273743085 525 2988377 SGTC_169 k015-0017 16.025 µM 1.24393427966056 0.124184048025195 no 406 0.106761875867714 524 1840002 SGTC_2119 5528445 120.635 µM 1.24346056566494 0.124277439614103 no 407 0.106849081907068 570 791935 SGTC_524 r073-0010 27.8 µM 1.24242178735141 0.124482404231044 no 408 0.107040490564526 577 2772106 SGTC_1224 0823-0416 294 µM 1.24204634550586 0.124556541958743 no 409 0.10710973150543 590 3598164 SGTC_1762 st045503 25.4615 µM 1.24156607479276 0.12465142501794 no 410 0.107198352613631 595 4645554 SGTC_34 0469-0683 81.75 µM 1.24018762445366 0.124924034444207 no 411 0.107453002354582 572 3690923 SGTC_1116 jasmonic acid  1.58368 µM 1.23844878899412 0.125268509197802 no 412 0.107774849785931 589 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_235 0330-0087 5 mM 1.2370456058112 0.125546972129727 no 413 0.108035075942229 615 46494818 YHR062C RPP1 SGTC_3141 9094609 49.47 µM 1.23573460604843 0.125807531241494 no 414 0.108278614812293 554 25236309 YDL196W YDL196W SGTC_339 3091-4833 71.4 µM 1.23068502840502 0.126814649946299 no 415 0.109220344876309 595 3240077 SGTC_2566 crystal violet carbinol 226 nM 1.22945920602169 0.127059979857425 no 416 0.109449841891385 526 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1356 1502-0781 85.8 µM 1.22495253723211 0.127964760187392 no 417 0.110296551933891 595 567702 SGTC_1817 st052116 64.4 µM 1.22091713537522 0.128778716989451 no 418 0.111058697953914 572 4361398 SGTC_362 0310-0100 9.03 µM 1.2179955833905 0.129370242740795 no 419 0.111612825556324 589 790235 SGTC_866 0495-0101 262 µM 1.21641849221509 0.129690337286273 no 420 0.111912771548175 578 635694 SGTC_2482 5981709 142.65 µM 1.21582804607938 0.129810318280237 no 421 0.112025216297539 635 877755 SGTC_3223 9129970 49.47 µM 1.21411713050398 0.130158417047889 no 422 0.112351499675113 651 17248386 SGTC_1952 st077036 64.1 µM 1.21002843651098 0.130992907553047 no 423 0.113133990704444 619 2937007 SGTC_2317 5986382 200 µM 1.20884274144705 0.131235594382727 no 424 0.113361633725629 630 877883 SGTC_2895 9054447 58.44 µM 1.20801932131947 0.131404313747987 no 425 0.113519915251137 579 2697450 SGTC_1441 4106-0040 13 µM 1.20775872089281 0.131457742143901 no 426 0.113570041852191 590 2904180 SGTC_1902 st060212 70.5 µM 1.20694349274933 0.131624977349442 no 427 0.113726953224224 621 688944 SGTC_2274 7947094 46.08 µM 1.2063513166634 0.131746547871992 no 428 0.113841029410624 624 2971028 SGTC_1321 1326-2144 215 µM 1.20530580045916 0.131961375744329 no 429 0.114042635602406 581 3513030 SGTC_3135 9127742 49.47 µM 1.20383084520113 0.132264853434252 no 430 0.114327482552916 575 3643468 SGTC_2148 5546263 113.568 µM 1.20119409505275 0.13280857288286 no 431 0.11483795971949 606 792097 SGTC_1664 st014217 9.02 µM 1.19908073398595 0.13324547499961 no 432 0.115248277331665 668 3982782 SGTC_1884 5633444 25 µM 1.19773191105151 0.133524838091938 no 433 0.115510700995058 640 5724239 SGTC_1249 0481-0015 10.2 µM 1.19713529417931 0.133648535518725 no 434 0.115626912634786 557 4227577 SGTC_2256 7954252 200 µM 1.19449616935954 0.134196654016945 no 435 0.116141969129397 523 2972920 SGTC_2117 5521686 200 µM 1.19200305542932 0.134715864046589 no 436 0.116630023610073 621 803312 SGTC_2688 kanamycin b 96.69 µM 1.19063506996052 0.135001342440528 no 437 0.116898438913528 1088 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2718 lomofungin 53.02 µM 1.18932654020031 0.135274801306505 no 438 0.117155597716309 597 5351222 A RNA synthesis inhibitor. SGTC_2459 5811157 9.22 µM 1.18745600568027 0.135666367896994 no 439 0.117523900037801 613 2870684 YBR192W RIM2 SGTC_3326 9140064 16.379 µM 1.18699925005091 0.135762100233121 no 440 0.117613958160547 617 1868434 SGTC_2929 9013348 24.6 µM 1.1857506617372 0.136024030445877 no 441 0.117860390524032 616 2995952 SGTC_1438 4092-1045 4 µM 1.18513578364142 0.136153147288801 no 442 0.117981882435221 643 1351342 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.18510513359714 0.136159585615479 no 443 0.117987940802411 685 1377 SGTC_3189 9110682 49.47 µM 1.1826718967669 0.136671374581814 no 444 0.118469603097816 619 17122418 SGTC_3163 9099914 49.47 µM 1.18181971670956 0.13685092640148 no 445 0.118638621355793 581 16268368 SGTC_1436 4092-1007 8.32 µM 1.17938362229571 0.137365093248202 no 446 0.119122726827138 615 2881121 SGTC_2379 9035213 200 µM 1.17924961094427 0.137393416175018 no 447 0.119149398235254 686 646551 SGTC_513 4245-1575 41.7 µM 1.17891573514581 0.137463997239474 no 448 0.119215865698711 758 719745 SGTC_3171 9103192 49.47 µM 1.17579826119821 0.138124223307217 no 449 0.119837750701888 622 13018434 SGTC_2597 laccaic acid a 100 µM 1.17560759219298 0.138164673694708 no 450 0.119875860131554 661 5491415 A textile dye. SGTC_3009 9080819 71.4286 µM 1.17503074342636 0.138287101213959 no 451 0.119991208175648 638 17027216 SGTC_1994 st072947 40.9 µM 1.17285237496848 0.138750094127419 no 452 0.120427505353228 657 5286565 YDL195W SEC31 SGTC_147 4466-0538 29.23 µM 1.17269037364046 0.138784568203265 no 453 0.120459996565199 660 6742687 YHR072W ERG7 SGTC_2138 5575593 77.673 µM 1.17247726156504 0.138829927591118 no 454 0.120502748021737 599 762213 SGTC_1983 st071813 46.9 µM 1.1716476329219 0.139006604285354 no 455 0.120669277854672 645 11838595 SGTC_139 0099-0334 718.624 µM 1.17142261562229 0.139054550068859 no 456 0.120714473081508 741 97690 SGTC_3104 9120930 49.47 µM 1.17098497169292 0.139147833717586 no 457 0.1208024089639 571 17014836 SGTC_1516 st013856 110 µM 1.17031198905305 0.139291362815599 no 458 0.120937719455535 608 5281404 A mutagen and neurotoxin. SGTC_1962 st076595 64.5 µM 1.1666065279256 0.140083441981141 no 459 0.121684652947192 649 279619 SGTC_493 zm226600 134 µM 1.1656128736316 0.140296364786883 no 460 0.121885500247199 662 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3074 9116018 49.47 µM 1.16411089101916 0.140618630521086 no 461 0.122189537779066 588 17027303 SGTC_3099 9120367 49.47 µM 1.16390369073563 0.14066312686651 no 462 0.122231521874214 642 24824940 SGTC_1651 st011928 86.1 µM 1.16256267161058 0.140951342319428 no 463 0.122503491644462 649 720198 SGTC_1785 bathophenanthroline 24 µM 1.16137227645379 0.141207520649536 no 464 0.122745269143468 639 72812 An iron chelator. SGTC_2227 7312221 64.1025 µM 1.16122358204192 0.141239542512202 no 465 0.122775493505825 630 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3161 9100388 49.47 µM 1.16027589399809 0.141443746123318 no 466 0.122968247914184 651 25236368 SGTC_3159 9100096 49.47 µM 1.15986313663948 0.141532747763064 no 467 0.123052266727344 631 25236875 SGTC_3311 9131146 2.8755 µM 1.15965406766024 0.141577843159108 no 468 0.123094839107997 668 4900406 YPR165W RHO1 SGTC_3312 9133330 71.43 µM 1.1594017757708 0.141632274535364 no 469 0.123146226645176 701 17617324 SGTC_2232 chlorophetanol 41.5365 µM 1.1586999934117 0.141783756968808 no 470 0.123289246765723 788 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2007 4011539 71.82 µM 1.15555712777034 0.142463502383623 no 471 0.123931176365994 654 45595301 SGTC_1466 k213-0079 57.5 µM 1.15238101980173 0.1431526733958 no 472 0.124582268469022 673 3657981 SGTC_284 0988-0104 32.6 µM 1.14742504055747 0.144232543615024 no 473 0.125602998494921 684 4666532 SGTC_1953 st076800 12.1 µM 1.1471696407208 0.144288341697716 no 474 0.125655758117688 677 297591 SGTC_1294 1000-1494 117 µM 1.14064026986987 0.145719777342362 no 475 0.127009826033499 643 712797 YDL207W GLE1 SGTC_1463 k081-0032 34.1 µM 1.14025841712322 0.145803785470054 no 476 0.127089328191853 547 977755 SGTC_76 0433-0009 400.328 µM 1.14004126143475 0.145851574536188 no 477 0.127134555686659 598 2841569 SGTC_2956 9076196 2.52 µM 1.13913028332824 0.146052166567874 no 478 0.127324409139822 666 16423868 SGTC_269 exalamide 29 µM 1.13842111327883 0.146208449891004 no 479 0.12747234100085 643 3316 A derivative of salicylamide. SGTC_629 3448-6466 76.7 µM 1.13806494209742 0.146286983456135 no 480 0.127546682872039 690 573744 SGTC_2173 5763948 167 µM 1.13791916986571 0.146319133508509 no 481 0.127577117890061 689 2867177 SGTC_3051 9093778 49.47 µM 1.13260007894425 0.147495503904707 no 482 0.128691117742664 610 17217378 SGTC_2810 7959871 45.46 µM 1.13162501260956 0.147711834962865 no 483 0.128896059857798 721 2974535 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.13021784351957 0.148024408023903 no 484 0.129192221406816 663 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1419 3993-2473 62.6 µM 1.12901488419146 0.148291970921198 no 485 0.129445777437103 696 704026 SGTC_1268 0828-0275 2.46 µM 1.1289687290575 0.148302243213045 no 486 0.129455512736733 708 745337 SGTC_407 eburnamonine 100 µM 1.12657408998448 0.148835847377276 no 487 0.129961299494929 611 3195 SGTC_440 fluspirilene 35.1 µM 1.12637620639463 0.148879999656184 no 488 0.130003156838921 689 3396 An atypical antipsychotic. SGTC_1859 st055998 20 µM 1.12150756574636 0.149969059556323 no 489 0.131035936446562 713 676301 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.11910762173727 0.150507849751629 no 490 0.131547114342329 741 165506 SGTC_2762 leflunomide 42.06 µM 1.11893932517876 0.1505456808436 no 491 0.131583012369928 713 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2714 st079313 56.9 µM 1.11854462988679 0.150634428558421 no 492 0.13166722826801 673 2939799 SGTC_2047 4141938 200 µM 1.11812047887284 0.150729838259358 no 493 0.131757770570686 628 3807862 SGTC_3207 9114163 49.47 µM 1.11741585266028 0.150888427754734 no 494 0.131908280055317 747 849233 SGTC_2903 5923464 63.88 µM 1.11660959274037 0.15107002805026 no 495 0.13208064412672 661 2876576 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.11644544336134 0.151107018524025 no 496 0.132115755372748 684 390807 SGTC_3057 9095946 49.47 µM 1.11409170147372 0.151638088535444 no 497 0.132619924187631 701 24540043 SGTC_382 3229-0966 23.2 µM 1.11364775695294 0.151738393732883 no 498 0.13271516496496 733 5722370 SGTC_2844 9010103 25.97 µM 1.11208480777039 0.152091878585378 no 499 0.133050844059223 678 2480525 SGTC_2155 5570423 76 µM 1.11087293148187 0.152366339043891 no 500 0.13331152414529 665 797402 SGTC_752 1896-0090 130 µM 1.11084448765727 0.152372784823324 no 501 0.133317646758533 699 772567 SGTC_515 4092-1064 102 µM 1.10960893456929 0.152652953598687 no 502 0.133583789769596 764 717353 SGTC_1363 1636-0063 10.4 µM 1.10944702311291 0.152689693263155 no 503 0.133618693193112 727 6072185 SGTC_130 0136-0219 337.655 µM 1.10825857959262 0.15295954496765 no 504 0.133875079155993 716 234244 SGTC_2867 9039098 71.43 µM 1.10727466114929 0.15318319567538 no 505 0.134087598081196 685 6463460 SGTC_1080 nisoldipine 24.4 µM 1.10575636721797 0.153528738230673 no 506 0.134415992626209 716 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3143 9086658 49.47 µM 1.10447501805727 0.153820756801101 no 507 0.13469356729355 786 25236626 SGTC_2106 5357045 167.29 µM 1.10438203773156 0.153841961248843 no 508 0.134713724627693 717 668842 SGTC_197 4544-0043 41.561 µM 1.1042951774179 0.153861771756877 no 509 0.134732557066002 721 896523 SGTC_111 0083-0039 52.457 µM 1.10287541626676 0.154185820531044 no 510 0.135040635733532 559 759313 SGTC_1518 st038567 90.8 µM 1.1003931555713 0.154753459839866 no 511 0.13558042966933 685 77966 SGTC_351 caspofungin 25 nM 1.10021292378364 0.154794728645804 no 512 0.135619680468665 836 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1085 doxorubicin 7.67 µM 1.09974653645112 0.154901554033308 no 513 0.135721286230034 751 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3345 9148410 3.559 µM 1.09965580090789 0.154922342543493 no 514 0.135741059663525 687 4903596 SGTC_463 ikarugamyin 104 µM 1.09913201762401 0.155042383069461 no 515 0.13585524307221 656 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.09779693866133 0.155348633862211 no 516 0.136146584273819 722 688667 SGTC_3229 9132204 49.47 µM 1.09746487340397 0.155424867525167 no 517 0.136219113976688 671 17682924 SGTC_292 k038-0015 474 µM 1.09650030242345 0.155646448239742 no 518 0.136429945531938 671 46368540 SGTC_3146 9095609 49.47 µM 1.09561231285871 0.155850620816088 no 519 0.136624235505106 719 17173999 SGTC_1750 st081859 2.357 µM 1.09535531709588 0.155909743954436 no 520 0.136680500842607 866 5291695 SGTC_648 0375-0473 33.3 µM 1.09197849048066 0.156687972836718 no 521 0.137421277807525 746 1713139 SGTC_2893 9048488 25.97 µM 1.09181691213148 0.156725274430822 no 522 0.137456791961878 682 6467338 SGTC_2593 nobiletin 86.24 µM 1.09128278968089 0.156848622261258 no 523 0.137574234132964 644 72344 An anti-infammatory. SGTC_1756 st041558 35.5 µM 1.08405623574697 0.158523767221492 no 524 0.139169932788428 800 3955792 SGTC_431 k089-0097 107 µM 1.08324924373549 0.158711556930158 no 525 0.139348903757823 771 5499420 SGTC_175 3793-3120 23.7 µM 1.08185755081373 0.159035750967913 no 526 0.139657914724173 668 5322297 SGTC_1061 3448-9325 110 µM 1.08060089881418 0.159328859811346 no 527 0.139937341277672 699 723482 SGTC_1679 SEC14.276 6.7 µM 1.07924084448255 0.159646485158933 no 528 0.140240188015791 764 1005053 YMR079W SEC14 SGTC_2853 9015042 58.44 µM 1.07800729061332 0.159934925849019 no 529 0.140515251285941 668 6457456 SGTC_2961 9083290 32.55 µM 1.07661449910604 0.160261010343199 no 530 0.140826262008272 685 17741490 SGTC_258 haloperidol 50.781 µM 1.07321094516429 0.161059687644731 no 531 0.141588240480323 708 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2136 5328288 199.296 µM 1.07165269699513 0.161426211192026 no 532 0.141938027333239 644 262395 SGTC_768 0384-0033 77.3 µM 1.07073155262732 0.16164313388805 no 533 0.142145075605002 751 3965305 YMR134W ERG29 SGTC_1045 1348-1485 165 µM 1.07049143955459 0.161699709948749 no 534 0.142199080080792 803 6810614 SGTC_74 000s-0487 160.283 µM 1.06932174697947 0.16197550047319 no 535 0.142462357329058 715 677548 SGTC_929 2805-0021 398 µM 1.068365816724 0.162201117437367 no 536 0.142677765115554 710 3098024 SGTC_1437 4092-1038 11.6 µM 1.06565395605267 0.162842279047243 no 537 0.14329004942544 775 3977136 SGTC_2205 7238770 200 µM 1.06387694422088 0.163263308176749 no 538 0.143692224393925 729 279867 SGTC_2925 9010536 32.5 µM 1.06154294523652 0.163817378398552 no 539 0.144221613472912 804 2994177 SGTC_450 aminopyrene 156 nM 1.06068923710713 0.164020345450097 no 540 0.144415576422178 764 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2824 7998404 51.95 µM 1.05871102931415 0.164491286320372 no 541 0.144865701664092 691 837851 SGTC_1748 st037455 53.6035 µM 1.05500095922233 0.165376882711807 no 542 0.145712443022167 739 580690 SGTC_2417 cerulenin 830 nM 1.05287138162386 0.165886605356111 no 543 0.146199971980571 724 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_908 3448-7491 47.7 µM 1.05208579831155 0.166074893877384 no 544 0.146380093619276 807 1203031 SGTC_154 3389-1638 511.116 µM 1.04906079353735 0.166801215664187 no 545 0.147075069631367 659 5238686 SGTC_2402 5553605 200 µM 1.0458825650354 0.167566531666816 no 546 0.147807627466759 788 6758546 SGTC_2307 7538926 6.34 µM 1.04490462429653 0.167802473719266 no 547 0.148033526164931 757 96582 SGTC_293 4049-0273 38.5 µM 1.0439577596393 0.168031121938866 no 548 0.148252466528091 711 1380311 SGTC_1650 st011916 45.8 µM 1.04309196266077 0.168240369397874 no 549 0.148452851393982 763 242528 SGTC_3156 9099931 49.47 µM 1.03924050528485 0.169173227250043 no 550 0.149346448357933 798 18111053 SGTC_1109 tnp00067 928.257 nM 1.03762856524144 0.169564637706783 no 551 0.149721506875906 756 676295 SGTC_1791 st048313 56.1 µM 1.03742080446207 0.169615128307744 no 552 0.149769893337224 711 1204976 SGTC_1144 3486-0183 12.5 µM 1.03715319031405 0.169680178851443 no 553 0.149832234723189 801 6744069 SGTC_280 3448-3607 3.04 µM 1.03678132973221 0.169770595751232 no 554 0.149918889307606 791 626179 SGTC_2172 5754775 163.918 µM 1.03484873765816 0.170240997758177 no 555 0.150369778903243 688 2263357 SGTC_2869 9037858 32.47 µM 1.03075201515442 0.171240917689679 no 556 0.151328562839438 713 27187042 SGTC_1477 0139-0234 16 µM 1.02991346705643 0.171446050908808 no 557 0.151525314166356 785 620880 SGTC_2267 7931562 200 µM 1.0294376482121 0.171562519830669 no 558 0.15163703271981 692 934880 SGTC_1778 st046819 58.9 µM 1.02687880867804 0.172189728446157 no 559 0.152238766991499 823 671715 SGTC_2968 9090663 33.37 µM 1.02524013121117 0.172592159617659 no 560 0.152624948399362 764 25236811 SGTC_62 0180-0423 3.232 µM 1.02441523329383 0.172794967188238 no 561 0.15281959492433 760 30102 YGL099W LSG1 SGTC_325 2810-4341 181 µM 1.02332710555578 0.17306272408564 no 562 0.153076606007777 798 774970 SGTC_3140 9094243 49.47 µM 1.02214158676275 0.173354746788948 no 563 0.153356946373236 822 19291112 SGTC_1780 st038448 24.544 µM 1.02151459005266 0.173509318394315 no 564 0.153505350099491 782 728868 YDL195W SEC31 SGTC_822 1487-0950 154 µM 1.01968003772107 0.173962088644673 no 565 0.153940116033621 778 1958375 SGTC_2388 9080168 200 µM 1.0172011035389 0.174575085520514 no 566 0.154528885589025 728 15943073 SGTC_692 k241-0027 77.8 µM 1.01618860083737 0.17482585371825 no 567 0.154769791807827 761 3600480 SGTC_2926 9010726 65.15 µM 1.01590482724316 0.174896177386408 no 568 0.154837354958167 763 2994293 SGTC_3192 9110362 49.47 µM 1.01496919666338 0.175128168864952 no 569 0.155060255578667 812 16649480 SGTC_2520 obtusaquinone 4.71 µM 1.01452222594616 0.175239065016252 no 570 0.15516681471701 795 5967872 SGTC_1449 4112-4002 201 µM 1.01371906934382 0.175438444926885 no 571 0.15535841107177 738 2059539 SGTC_558 k064-0027 21.3 µM 1.01354128291439 0.175482599016645 no 572 0.155400843861035 805 5088526 SGTC_2639 lactacystin 53 µM 1.01292723409341 0.175635155078744 no 573 0.155547459443164 833 3870 A proteasome inhibitor. SGTC_659 k018-0002 107 µM 1.01182931945779 0.175908133549301 no 574 0.155809834358146 809 6797879 YHR007C ERG11 SGTC_2261 9010538 184.68 µM 1.00982882416049 0.176406214287209 no 575 0.156288653926176 675 6457250 SGTC_2433 5607874 27.82 µM 1.00619280823039 0.177313786837021 no 576 0.157161415501877 772 2252428 SGTC_3258 9138477 49.47 µM 1.00431042819645 0.177784797007916 no 577 0.157614504373594 792 4970355 SGTC_3193 9111931 49.47 µM 1.00316361923073 0.178072138719722 no 578 0.157890961572456 798 17087244 SGTC_1025 k007-0731 70 µM 1.00156554926106 0.17847303527887 no 579 0.158276733370773 770 6256118 SGTC_1274 0865-0114 173 µM 1.00127430295042 0.178546159392403 no 580 0.158347106385074 790 870624 SGTC_248 streptozotocin 5.23457 mM 1.0004611879373 0.178750410561293 no 581 0.158543685685026 846 5300 DNA alkylating agent. SGTC_2154 5570129 200 µM 1.00044667470068 0.178754057562756 no 582 0.158547195869301 838 673366 SGTC_110 0850-0284 111.64 µM 1.00042048748555 0.178760638212854 no 583 0.158553529661317 666 3906265 SGTC_2871 9038510 12.99 µM 0.999370877544397 0.179024522846477 no 584 0.158807531033257 822 4945164 SGTC_2643 anethole 100 µM 0.999312597163112 0.179039182418215 no 585 0.158821642462256 840 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2654 protoveratrine a 100 µM 0.998082247880059 0.179348834920914 no 586 0.159119738757816 794 5702278 A heart drug and vasodilator. SGTC_1844 rapamycin 4 nM 0.99317025442517 0.18058843122555 no 587 0.160313495786142 881 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2966 9084041 48.03 µM 0.99095090702866 0.181150266331911 no 588 0.160854776396011 739 17741380 SGTC_1860 st056228 74.6 µM 0.990751524852721 0.181200794132223 no 589 0.160903462413116 785 688679 SGTC_220 paclitaxel 373.376 µM 0.990097782963786 0.181366528526442 no 590 0.161063163454686 730 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_302 1094-0063 18.9 µM 0.990032036145667 0.181383201684571 no 591 0.161079230310106 737 5440289 SGTC_740 k014-0057 261 µM 0.988646546302612 0.181734780125679 no 592 0.16141805213601 889 4012779 SGTC_506 n9-isopropylolomoucine 153 µM 0.987952523865867 0.181911053690569 no 593 0.161587950053341 837 6610355 SGTC_731 3966-0296 387 µM 0.987805515247013 0.181948405875994 no 594 0.16162395297905 813 660956 SGTC_2816 7982706 58.44 µM 0.987049821699211 0.182140489390413 no 595 0.161809107495387 769 2981853 SGTC_732 3970-1727 52.7 µM 0.986885773864045 0.182182204096876 no 596 0.161849319549851 822 1275699 SGTC_1990 st072050 59.8 µM 0.986735635558662 0.182220387068298 no 597 0.161886127751398 812 17233948 SGTC_1784 st039334 36.3 µM 0.985902100704838 0.182432461481479 no 598 0.162090577972598 794 3496984 SGTC_1390 3413-2614 145 µM 0.984747487668496 0.182726481706046 no 599 0.162374060226149 832 3421432 SGTC_2526 patulin 37.61 µM 0.984240408105524 0.182855702086665 no 600 0.162498661050209 850 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2904 7225135 42.03 µM 0.981523888508413 0.183548930550938 no 601 0.16316723003037 871 4446116 SGTC_979 1426-2828 121 µM 0.981513348822193 0.183551623358624 no 602 0.163169827453473 866 747872 SGTC_3077 9117319 49.47 µM 0.980737623954818 0.183749882605379 no 603 0.163361072536134 779 17154678 SGTC_698 k064-0052 127 µM 0.979956844979012 0.183949568235828 no 604 0.163553710621665 830 5088751 SGTC_3028 9087778 49.47 µM 0.97990711546418 0.183962291224669 no 605 0.163565985156044 855 17217395 SGTC_2431 5490079 200 µM 0.978147561932584 0.184412814761578 no 606 0.164000673610177 836 5722345 SGTC_3338 9144300 39.5675 µM 0.977529746742983 0.184571165451434 no 607 0.164153479224029 835 4901274 SGTC_2878 9043973 25.97 µM 0.976242106199839 0.184901469099263 no 608 0.164472250930623 798 6465167 SGTC_670 4204-0025 119 µM 0.974488743270741 0.185351829403734 no 609 0.16490696282562 859 719039 SGTC_3102 9121669 49.47 µM 0.97320581604746 0.185681786946825 no 610 0.165225510402032 793 41905072 SGTC_3134 9127454 49.47 µM 0.972243421347535 0.185929545421926 no 611 0.16546473181336 856 24262820 SGTC_2553 4-methylesculetin 85.09 µM 0.970896935539767 0.186276527998618 no 612 0.165799802169749 841 5319502 SGTC_162 k030-0015 37.8 µM 0.967312333301323 0.187202216031122 no 613 0.166693960026609 903 1809920 YMR134W ERG29 SGTC_3302 9125395 16.351 µM 0.966989915635006 0.187285616412262 no 614 0.166774537459643 808 17599668 SGTC_2540 epiandrosterone 100 µM 0.966798711849787 0.18733508630286 no 615 0.166822334272341 1010 441302 A steroid. SGTC_1141 3253-0389 52.6 µM 0.966247298954633 0.187477797833486 no 616 0.166960225061714 836 5402031 SGTC_3201 9113999 49.47 µM 0.96613717974889 0.187506305903717 no 617 0.166987771168542 784 16649224 SGTC_733 4069-0007 56.1 µM 0.966050682963391 0.187528700392267 no 618 0.167009410227701 877 5717425 YNL287W SEC21 SGTC_1655 st012546 55.1 µM 0.964466970549691 0.187939024284909 no 619 0.167405930099253 805 720985 YLR208W SEC13 SGTC_544 k015-0020 52.4 µM 0.964430162555432 0.18794856745118 no 620 0.167415153059047 819 3008304 SGTC_1102 cgs 12066b 26.1 µM 0.964043710022403 0.188048780613753 no 621 0.167512006031419 801 6438352 A 5-HT1B full agonist. SGTC_2349 9023730 187.07 µM 0.960369426501209 0.189003226366715 no 622 0.168434659863353 840 4126287 SGTC_1933 st074711 15.9 µM 0.960296113701866 0.189022300690665 no 623 0.168453102720733 873 17250958 SGTC_531 3788-1495 174 µM 0.959549520112161 0.189216614888684 no 624 0.168640992693116 802 2896655 SGTC_3210 9128157 49.47 µM 0.959055274851085 0.189345318602231 no 625 0.168765450006779 741 17590849 SGTC_486 niguldipine 82 µM 0.957926425363449 0.189639478169615 no 626 0.169049930119372 813 1236 A calcium channel blocker. SGTC_647 0140-0236 81 µM 0.955373951772871 0.19030564643734 no 627 0.16969431091932 941 990837 SGTC_2818 7996756 12.99 µM 0.952448762513492 0.191070854681087 no 628 0.170434719713088 786 2241621 SGTC_2455 5377712 9.75 µM 0.950585418247356 0.191559274335792 no 629 0.170907436859866 758 2243908 SGTC_3103 9120822 49.47 µM 0.949921069979072 0.191733598043515 no 630 0.171076179946942 897 17141819 SGTC_2913 7966556 36.57 µM 0.94971689630047 0.191787192333151 no 631 0.171128061039242 844 2976516 SGTC_2079 5212404 121 µM 0.94910089794685 0.191948943551425 no 632 0.171284648879027 888 758462 SGTC_1108 betulinic acid 729.144 nM 0.949074686029945 0.191955828229021 no 633 0.171291314024631 851 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3184 9108758 49.47 µM 0.948178122881747 0.192191405551055 no 634 0.171519391223912 852 902885 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.94748846702763 0.192372737038782 no 635 0.171694965152248 843 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3286 9117135 37.221 µM 0.945264233990685 0.192958267955708 no 636 0.172261996607917 808 3438150 SGTC_2620 irigenin 100 µM 0.944646988559873 0.193120950985008 no 637 0.172419564690804 889 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2517 totarol 10 µM 0.943969307776575 0.193299658936343 no 638 0.17259266632127 791 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_480 am 92016 50 µM 0.943567355312043 0.193405703559155 no 639 0.172695390340628 793 2129 K+ channel blocker. SGTC_2732 terfenadine 20 µM 0.943168458398825 0.193510977138069 no 640 0.172797371999575 837 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2353 9059630 146.67 µM 0.941689000983714 0.193901728443944 no 641 0.173175943965539 889 4779114 SGTC_3109 9122853 49.47 µM 0.941632048293319 0.193916780279464 no 642 0.173190527893898 933 1234709 SGTC_881 0833-0569 170 µM 0.940914304166505 0.194106531494903 no 643 0.173374388336258 827 5418700 SGTC_2932 9016711 44.54 µM 0.940388399089898 0.194245637675243 no 644 0.173509185305727 913 7117328 SGTC_474 dl-dihydrosphingosine 5 µM 0.939401789720229 0.194506767625358 no 645 0.173762247238795 868 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2618 avocadyne 43.43 µM 0.939040299897943 0.194602498078651 no 646 0.1738550268833 854 3015189 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.937665134071187 0.194966934138757 no 647 0.174208263505688 868 6312947 SGTC_2157 5649910 96.377 µM 0.934599978126496 0.195780730554755 no 648 0.174997245155739 854 2858091 SGTC_3273 9137859 49.47 µM 0.933966844142814 0.195949083659185 no 649 0.175160498096663 878 2377234 SGTC_1588 farnesol 29.9 µM 0.933942863366468 0.195955461978727 no 650 0.175166683413035 853 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_343 4130-2827 29.8 µM 0.932738398358749 0.196275983217279 no 651 0.175477527004003 866 1118244 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.932060361566719 0.196456555925736 no 652 0.175652665788592 951 6708784 An antioxidant flavonoid SGTC_2183 6420625 130.508 µM 0.931871650676274 0.196506830743202 no 653 0.175701430031258 919 2897619 SGTC_1210 3013-0140 750 nM 0.927979223505363 0.197545557442423 no 654 0.176709173494585 937 905973 SGTC_787 4152-0075 138 µM 0.926390760236022 0.197970404086426 no 655 0.177121472067344 866 9566539 SGTC_1573 oleylamine 1.06 µM 0.92577793695107 0.198134455767364 no 656 0.177280697652226 856 5356789 An amine of the fatty acid oleic acid. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.9240993276379 0.19858423656954 no 657 0.177717301672794 917 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2598 perillyl alcohol 100 µM 0.92326880406536 0.19880700163606 no 658 0.177933570379706 893 10819 An apoptosis inducer. SGTC_1999 st074831 12.5 µM 0.922768579594226 0.198941245731053 no 659 0.178063909106494 883 17112523 SGTC_1950 st077106 7.18 µM 0.921134250020002 0.199380227690133 no 660 0.178490170261076 891 13831864 SGTC_3307 9126885 69.2785 µM 0.917223329722882 0.200433068310428 no 661 0.179512812042107 874 24824909 SGTC_3054 9094397 49.47 µM 0.916861670027413 0.200530597425716 no 662 0.179607565818026 922 2598354 SGTC_2401 5128683 200 µM 0.915040328374569 0.201022193366914 no 663 0.180085229556268 829 708373 SGTC_2314 7727897 200 µM 0.915031741650521 0.201024512709146 no 664 0.180087483391447 881 900724 SGTC_2026 5148700 152 µM 0.913858705330816 0.201341509978349 no 665 0.180395547293388 897 79838 SGTC_3295 9122362 53.5725 µM 0.911849346804333 0.201885207787462 no 666 0.180924014636295 836 4730473 SGTC_2293 7624732 200 µM 0.908885162323531 0.202688867886861 no 667 0.181705373361775 856 894453 SGTC_1292 0kpi-0043 232 µM 0.907640712378784 0.203026836532025 no 668 0.182034038551977 868 3333905 SGTC_1259 0671-0132 43 µM 0.905607895800799 0.203579633625398 no 669 0.182571714046945 864 X1259 SGTC_3172 9105863 49.47 µM 0.904549570661209 0.20386778586355 no 670 0.182852030900215 867 2348785 SGTC_568 1193-0097 7.48 µM 0.9045117548597 0.203878086541168 no 671 0.182862052078193 897 3646150 SGTC_597 k018-0003 82.8 µM 0.903845492131233 0.204059621269667 no 672 0.18303866775454 997 6786234 SGTC_1237 0330-0133 46.1 µM 0.903690083411417 0.204101978891631 no 673 0.183079879442643 870 X1237 YHR072W ERG7 SGTC_1065 prochlorperazine maleate 2.48 µM 0.90283468268323 0.204335217462977 no 674 0.183306820435866 924 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3088 9117578 49.47 µM 0.902686956236759 0.204375513483328 no 675 0.183346030566458 925 678341 SGTC_1323 1348-1351 11.2 µM 0.902143407116397 0.204523820589586 no 676 0.183490346512345 873 6989654 SGTC_578 3460-0051 92 µM 0.901736611919692 0.204634856346227 no 677 0.183598399683525 1011 2876744 SGTC_2774 tamoxifen 10.92 µM 0.899924737658192 0.205129847353507 no 678 0.184080152224032 908 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2842 9000675 19.48 µM 0.899149848437357 0.205341758552046 no 679 0.184286424674389 850 2989072 SGTC_749 1000-0129 128 µM 0.898563004860134 0.205502330858067 no 680 0.184442735786892 974 708470 SGTC_2059 5238311 157 µM 0.896170264090138 0.2061578045549 no 681 0.185080917293237 865 703021 SGTC_3062 9077494 49.47 µM 0.895905746382673 0.206230343241816 no 682 0.185151552422954 885 16459633 SGTC_2603 homopterocarpin 100 µM 0.894891654686708 0.206508577743615 no 683 0.185422504143448 903 101795 A weak amylase inhibitor. SGTC_2987 9018338 71.43 µM 0.894355427729032 0.206655791198692 no 684 0.185565876239941 921 5055682 SGTC_745 0469-0705 296 µM 0.893696865488232 0.206836675064104 no 685 0.18574205146973 1008 3486736 SGTC_562 3772-2733 112 µM 0.892980459879177 0.207033552856481 no 686 0.18593381844779 982 2876874 YIL048W NEO1 SGTC_964 1287-0107 19.4 µM 0.892033706850897 0.207293903199307 no 687 0.186187432917373 929 51516812 YPR165W RHO1 SGTC_1082 camptothecin 424.86 nM 0.890528226850893 0.207708297931329 no 688 0.186591159401687 837 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2600 tangeritin 87.95 µM 0.889847396236608 0.207895862282342 no 689 0.186773916481303 870 68077 A bioactive flavone. SGTC_2619 obliquin 87.91 µM 0.88845790188567 0.208278969029406 no 690 0.187147245611412 963 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3247 9135149 49.47 µM 0.886703625655626 0.208763246617263 no 691 0.187619242918281 875 8934436 YOR116C RPO31 SGTC_1393 3470-5649 58.2 µM 0.885535768119351 0.209086007696053 no 692 0.187933868587208 830 4108395 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.885352380930993 0.209136717139701 no 693 0.187983303433351 935 5357218 A potent inhibitor of glutathione S-transferases. SGTC_709 3807-1509 243 µM 0.884099507545968 0.209483350025277 no 694 0.188321249512871 944 1886677 YPL242C IQG1 SGTC_1189 1431-2119 7.28 µM 0.884076572092956 0.209489698733294 no 695 0.188327439540286 958 3107275 SGTC_2255 7941087 197.44 µM 0.883829217170786 0.209558175652068 no 696 0.188394205899117 995 935561 SGTC_1421 4029-0249 71.4 µM 0.883599247203977 0.209621851586365 no 697 0.188456292783528 1011 2894095 SGTC_2558 carylophyllene oxide 100 µM 0.883144573631122 0.209747778746788 no 698 0.188579081882113 997 6708694 An oxygenated terpenoid and antifungal agent. SGTC_918 glabranin 770.725 nM 0.881985201676417 0.210069081595624 no 699 0.188892404937179 932 124049 Also referred to as licorice root. SGTC_2822 7994718 71.43 µM 0.881683974303133 0.210152609623685 no 700 0.188973864824438 833 1018011 SGTC_2845 9003024 42.97 µM 0.880877969972959 0.210376204325192 no 701 0.189191936217381 944 2990173 SGTC_340 k038-0059 454 µM 0.879085816661778 0.21087386812573 no 702 0.189677373701423 950 23733424 SGTC_3191 9110352 49.47 µM 0.878904384182754 0.210924288640089 no 703 0.189726560675863 902 17122424 SGTC_618 k072-0232 33.2 µM 0.877928212720246 0.211195690297424 no 704 0.189991338774302 905 5872756 YGL099W LSG1 SGTC_3329 9141233 27.5565 µM 0.877498822668265 0.211315136936644 no 705 0.190107879020395 933 4909101 YNL103W MET4 SGTC_2159 5658611 73.75 µM 0.877405551395491 0.211341088134256 no 706 0.190133199472563 976 793844 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.876941895217615 0.211470120543014 no 707 0.19025909946436 926 7104 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.8767300600639 0.211529088197236 no 708 0.190316637671314 946 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2617 dihydrotanshinone i 20.83 µM 0.876463034428185 0.211603432706871 no 709 0.190389181824104 964 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3091 9116372 49.47 µM 0.87497731757224 0.212017360948913 no 710 0.190793123781595 897 17169793 SGTC_3098 9119039 49.47 µM 0.873938952710036 0.212306935579162 no 711 0.191075750058369 943 17161528 SGTC_2729 fluphenazine 10.66 µM 0.872304182537616 0.212763301207811 no 712 0.191521228257745 973 3372 An atypical antipsychotic. SGTC_2808 7946468 45.46 µM 0.87072733421418 0.213204039398954 no 713 0.191951524963974 944 2970879 SGTC_208 k072-0098 12.366 µM 0.869028420872069 0.213679490806787 no 714 0.192415792880434 1032 5948901 SGTC_2735 sertaconazole 140 nM 0.867381051013546 0.214141106726505 no 715 0.19286663038629 937 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2171 5739187 198.077 µM 0.866351330338061 0.214429943248479 no 716 0.193148762603141 925 2262761 SGTC_2088 5278280 127.392 µM 0.86427053013647 0.215014298370587 no 717 0.193719647569557 972 791502 SGTC_2856 9022925 19.48 µM 0.864046631986318 0.215077231175385 no 718 0.193781137147818 937 4944862 SGTC_2585 alliin 100 µM 0.863952837181787 0.215103597993065 no 719 0.193806899730657 963 87310 A garlic compound which reacts with lipids. SGTC_1839 st053978 48 µM 0.863804296995211 0.215145358217559 no 720 0.193847703477661 959 3788398 SGTC_2996 9066192 71.4286 µM 0.863281007497212 0.215292512035386 no 721 0.19399149196073 935 6472854 SGTC_3243 9134147 49.47 µM 0.862921064748011 0.215393765141306 no 722 0.194090434053248 1011 24282180 SGTC_1001 4048-4355 44.4 µM 0.862081963374756 0.215629914422821 no 723 0.194321207978759 937 21824233 SGTC_1093 fluphenazine 7.97 µM 0.861588698948037 0.215768804441804 no 724 0.194456946010089 973 6602611 An atypical antipsychotic. SGTC_2817 7995342 71.43 µM 0.857491534538581 0.21692445844803 no 725 0.195586645664626 904 18879975 SGTC_2294 7971431 200 µM 0.857376314459913 0.216957009281668 no 726 0.195618472474942 873 5741572 SGTC_1707 st032323 6.317 µM 0.855748544110342 0.217417172394542 no 727 0.196068441304834 948 3132057 YMR211W DML1 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.853742523296923 0.217985039530623 no 728 0.196623833655422 1004 5282309 SGTC_5 0352-0601 109.883 µM 0.851014141725316 0.218758764366611 no 729 0.197380748572758 926 762456 SGTC_1770 st043884 66.3 µM 0.848914455050427 0.219355276129384 no 730 0.197964447416728 1009 670149 SGTC_922 1866-0035 480 µM 0.847666882107382 0.219710148353053 no 731 0.198311757577818 1046 3156169 SGTC_1235 benzylparaben 21.5 µM 0.847335392608041 0.219804495966036 no 732 0.198404102295815 923 7180 SGTC_2419 paclitaxel 166.5 µM 0.847292926583205 0.219816584207343 no 733 0.198415934147199 1004 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_215 1287-0124 461.5 µM 0.846495698187805 0.220043591479991 no 734 0.198638136324891 964 5560863 SGTC_1 0258-0098 57.368 µM 0.84395159270431 0.220768913044406 no 735 0.199348228134939 862 6790032 YDR047W HEM12 SGTC_2731 amoxapine 43.43 µM 0.842736594859683 0.22111579004801 no 736 0.199687887891505 962 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.841976779172345 0.221332872770556 no 737 0.199900475664599 914 6857784 SGTC_181 1447-1644 8.07 µM 0.839410014289413 0.222067109568874 no 738 0.200619633084909 981 534600 SGTC_2680 butyl paraben 22.24 µM 0.838572234638568 0.222307061552351 no 739 0.200854698426329 994 7184 An antifungal and steroid mimetic. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.83829272222613 0.222387150771236 no 740 0.200933161150166 1070 6708561 SGTC_1446 4239-0190 62 µM 0.835879266611442 0.223079366965131 no 741 0.201611413745218 1002 1340085 SGTC_1318 1280-3875 124 µM 0.8353806429258 0.2232225326812 no 742 0.201751712544278 981 373245 SGTC_2356 9061756 188.97 µM 0.834878736832501 0.223366693651395 no 743 0.20189299395205 986 20104043 SGTC_231 b-estradiol 524 µM 0.834681419824337 0.223423382923602 no 744 0.201948552878236 923 450 A steroid. SGTC_2418 pentamidine 31.67 µM 0.833972563696877 0.223627105144601 no 745 0.202148222334096 995 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_601 0986-0029 62.9 µM 0.833966475978802 0.223628855186121 no 746 0.202149937624157 1002 24747981 SGTC_1734 st037168 69.4 µM 0.833260696673739 0.223831798949604 no 747 0.202348858720313 946 708907 SGTC_878 0828-0289 13.7 µM 0.832967620449182 0.223916102489988 no 748 0.202431495478207 973 745350 YLR208W SEC13 SGTC_321 4534-3890 65.3 µM 0.83294249825077 0.223923329743964 no 749 0.202438579956645 1023 699746 SGTC_2789 5281112 71.43 µM 0.832900274455906 0.223935477151853 no 750 0.202450487431838 963 765948 SGTC_3239 9133757 49.47 µM 0.832883506996743 0.22394030110366 no 751 0.202455216116451 1007 17036923 SGTC_2190 6049624 200 µM 0.832370591722656 0.224087893941749 no 752 0.202599898117171 950 2265554 SGTC_2382 9035899 200 µM 0.831883377319215 0.224228142435877 no 753 0.202737387690548 995 6462679 SGTC_2043 5101342 149 µM 0.831573938272392 0.224317242770294 no 754 0.202824738850635 955 678451 SGTC_3154 9100113 49.47 µM 0.828158592967523 0.225301996506346 no 755 0.20379034514381 998 25237525 SGTC_2238 6671620 73.2395 µM 0.827918525446558 0.225371307650529 no 756 0.203858321351661 1044 729941 SGTC_708 3448-5400 146 µM 0.826698163844644 0.225723831220056 no 757 0.204204081176954 1016 3462195 SGTC_2049 5262831 67.185 µM 0.826692711198344 0.22572540701545 no 758 0.204205626835162 997 763417 SGTC_2724 maprotiline 69.64 µM 0.824948450374611 0.226229811495248 no 759 0.204700428872909 1024 4011 A tricyclic antidepressant. SGTC_1166 k206-0078 225 µM 0.824622773228461 0.226324061153069 no 760 0.204792894072591 1033 5404595 SGTC_173 1273-0061 2.693 µM 0.823069358093783 0.226773918324132 no 761 0.205234276359385 971 2847414 YPL266W DIM1 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.8218363712301 0.227131340764526 no 762 0.20558501521244 947 688803 SGTC_771 0250-0039 27.3 µM 0.821460758214907 0.227240287820439 no 763 0.20569193380005 974 3005115 SGTC_3121 9125696 49.47 µM 0.821207063536794 0.227313888960192 no 764 0.205764166890591 1044 1235365 SGTC_1302 1159-0335 255 µM 0.820047874922417 0.227650360137688 no 765 0.206094407760121 990 649284 SGTC_1171 0368-0077 21.4 µM 0.819401770789462 0.227838022789325 no 766 0.206278612481593 957 3239779 SGTC_766 1391-0721 126 µM 0.818987026585349 0.22795853219892 no 767 0.206396907739821 1017 1020919 YIL115C NUP159 SGTC_947 3447-0010 211 µM 0.817834308560864 0.228293657906767 no 768 0.20672590235071 1042 748350 SGTC_1777 st045864 34.765 µM 0.81744258492336 0.228407605369185 no 769 0.206837773945071 1019 4691462 SGTC_1213 1315-0166 115 µM 0.81514705649084 0.229075987607339 no 770 0.207494069432835 896 768401 SGTC_2733 amorolfine 100 µM 0.815116749439294 0.229084819354215 no 771 0.207502742494545 999 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_476 mead acid 10 µM 0.815068237402326 0.229098956594809 no 772 0.207516625778627 1009 5312531 An omega 9 fatty acid. SGTC_1729 st035615 45.989 µM 0.814909662225574 0.229145171538379 no 773 0.207562011010111 961 17385451 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.814259831017168 0.229334612108475 no 774 0.207748058126574 1048 115019 SGTC_446 go6976 132 µM 0.813677401904938 0.229504478018819 no 775 0.207914891656761 1013 3501 A protein kinase C inhibitor. SGTC_2975 9084847 53.72 µM 0.813250524222318 0.22962902199125 no 776 0.208037218581203 1002 27211724 SGTC_1328 1441-0025 69.2 µM 0.810829038429341 0.230336220181534 no 777 0.20873192801352 991 4562601 SGTC_2897 9048598 12.99 µM 0.809590090604242 0.230698526999686 no 778 0.209087902636965 1022 6467404 SGTC_1638 st008370 60.6 µM 0.809122940579303 0.230835218781315 no 779 0.20922221698555 1032 24207134 SGTC_1511 0906-3109 28.5 µM 0.80863184000961 0.23097896743619 no 780 0.209363472312203 1125 2882180 SGTC_2202 7226349 200 µM 0.808315809157952 0.231071498350417 no 781 0.209454401981559 1008 844334 SGTC_3220 9131269 49.47 µM 0.807881758970458 0.231198617949169 no 782 0.209579326513246 1043 17722206 SGTC_2348 9022543 33.42 µM 0.807308562077427 0.231366548994616 no 783 0.209744366166195 1020 3162678 YDL140C RPO21 SGTC_112 phenothiazine 287.218 µM 0.806408921838914 0.231630256148159 no 784 0.210003552150136 1056 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1199 1638-0010 4.46 µM 0.804617031237839 0.232156003059569 no 785 0.210520355474631 1001 3111136 SGTC_3279 9140807 49.47 µM 0.804008050270916 0.232334831285681 no 786 0.210696162886287 1070 45595718 SGTC_3078 9116413 49.47 µM 0.803877947540354 0.23237304609099 no 787 0.210733733555328 1021 17177322 SGTC_781 4335-2806 94.4 µM 0.801440849203559 0.233089535764947 no 788 0.211438237357462 1115 845254 SGTC_2779 methotrexate 400 µM 0.801297293607848 0.233131778315133 no 789 0.211479778638595 1141 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_103 0844-0104 51.839 µM 0.800480568836026 0.233372187923637 no 790 0.211716208614297 1114 5375804 SGTC_870 0573-2213 57.6 µM 0.798486447694365 0.233959751287605 no 791 0.212294127295481 1058 3916321 SGTC_355 1311-2252 105 µM 0.798435400739447 0.233974802909636 no 792 0.212308933368517 1004 5338538 SGTC_2110 5483698 200 µM 0.79831955397195 0.234008963288884 no 793 0.212342536743788 1041 2848765 YHR062C RPP1 SGTC_1024 4507-0395 26 µM 0.798264385458311 0.234025232105688 no 794 0.212358540425739 998 4201836 SGTC_3280 9140961 49.47 µM 0.797952866719704 0.23411710860339 no 795 0.212448921263049 992 4901226 SGTC_1160 4092-0570 10.5 µM 0.797057755487347 0.234381215672846 no 796 0.212708744641504 1022 4994975 SGTC_1330 1469-0054 61.8 µM 0.796512936709296 0.234542047874375 no 797 0.212866979636856 1087 7102664 SGTC_974 1326-0144 138 µM 0.795531299536496 0.234831984254488 no 798 0.213152255772474 1063 5411856 SGTC_726 3448-4391 34.2 µM 0.793605222566263 0.235401445663939 no 799 0.213712645567654 1083 1356692 SGTC_1046 2001-0062 216 µM 0.792401368178759 0.235757762384102 no 800 0.214063340956661 994 739778 SGTC_851 0394-0702 453 µM 0.792239785184225 0.235805610332197 no 801 0.214110437255969 1095 762646 SGTC_3288 9119690 36.221 µM 0.792154282094089 0.235830931668864 no 802 0.21413536112435 992 17595618 YKL019W RAM2 SGTC_3112 9123419 49.47 µM 0.790611475319852 0.23628808407245 no 803 0.214585374189753 1112 17015854 SGTC_2330 7979373 200 µM 0.789269857957775 0.236686017946384 no 804 0.214977149881836 1025 1863007 SGTC_1225 1216-0074 20.6 µM 0.787825623658325 0.237114800468698 no 805 0.21539935540943 1041 4241466 SGTC_3120 9124077 49.47 µM 0.785569846860698 0.237785377066341 no 806 0.216059767746555 1147 18774327 YGL155W CDC43 SGTC_1724 st037281 8.293 µM 0.784633827761268 0.238063933273707 no 807 0.216334145244237 1065 574124 YDL195W SEC31 SGTC_2649 anisomycin 9.56 µM 0.783540927154305 0.238389403099073 no 808 0.21665476488087 1027 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2321 7390090 138.78 µM 0.781428088197233 0.239019304618344 no 809 0.21727537818649 1011 649046 SGTC_2260 7964312 200 µM 0.781229660379629 0.239078508687665 no 810 0.217333715939949 1007 231951 SGTC_59 0330-0160 1.33 µM 0.780172499233458 0.239394064465021 no 811 0.217644673609151 1121 4293482 SGTC_2056 5235370 200 µM 0.780130028041167 0.239406746592882 no 812 0.217657171619848 1005 5511916 SGTC_122 0236-0016 402.397 µM 0.778649033691349 0.239849208918407 no 813 0.218093243202233 1171 6808838 SGTC_1873 rapamycin 2 nM 0.77860087454586 0.239863604444238 no 814 0.218107431877285 1066 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1522 st012842 45.6 µM 0.777487045006242 0.240196677071939 no 815 0.218435737396873 956 3491067 YOR116C RPO31 SGTC_3046 9092212 49.47 µM 0.777101092628777 0.240312148635565 no 816 0.218549564700238 1066 25236637 SGTC_1068 loratadine 26.9 µM 0.776977283381961 0.240349197040011 no 817 0.218586086471866 1038 3957 A H1 histamine antagonist. SGTC_2323 6148992 148.28 µM 0.776977276084883 0.240349199223664 no 818 0.218586088624493 985 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_636 0kpi-0074 126 µM 0.775530043408888 0.240782496600313 no 819 0.219013259911178 1042 616434 SGTC_514 4466-0038 2.65 nM 0.774769678739349 0.241010317847157 no 820 0.219237884597839 1067 5722064 SGTC_706 4262-0057 46.9 µM 0.773716167441914 0.241326165617369 no 821 0.219549328537547 1082 883298 SGTC_1226 3909-7979 35.4 µM 0.771321205136367 0.242045022907284 no 822 0.220258283201619 1097 6615510 SGTC_741 4582-0002 126 µM 0.770889527046651 0.242174716178234 no 823 0.220386207653324 1054 2912688 SGTC_2124 5246320 200 µM 0.770810595584026 0.242198434402963 no 824 0.22040960298432 1036 579342 SGTC_2182 6325192 200 µM 0.769860435779131 0.242484048031419 no 825 0.220691342582682 1050 736248 SGTC_3350 9150499 3.57 µM 0.76956847935555 0.24257184540527 no 826 0.220777954363985 1110 4910996 YPR165W RHO1 SGTC_1848 st056003 16.4 µM 0.768991180087772 0.242745501975044 no 827 0.220949273228802 1167 146492 SGTC_869 0564-0080 44.1 µM 0.766875525546323 0.243382483793231 no 828 0.221577763213438 1044 6843321 SGTC_2721 ifenprodil 61.44 µM 0.766783248787007 0.243410287045169 no 829 0.221605198777408 1076 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2992 9074591 71.4286 µM 0.766777295387228 0.243412080880507 no 830 0.221606968898436 1072 17741321 SGTC_1149 3909-7961 23.3 µM 0.766450355760549 0.243510602928878 no 831 0.221704190080689 1069 735261 SGTC_2484 5809818 12.04 µM 0.765400490696957 0.243827121479187 no 832 0.222016550432429 1044 2870548 SGTC_820 1582-0060 59.9 µM 0.764758379245318 0.244020817816851 no 833 0.222207717945998 1056 3848840 SGTC_429 1112-0049 25.5 µM 0.764007600324522 0.244247399495401 no 834 0.222431356691828 1009 2836170 SGTC_686 1319-0111 510 µM 0.759536638198461 0.245599061319744 no 835 0.223765802876152 1121 4562600 SGTC_1605 st000082 49.1 µM 0.758169010004783 0.246013323852782 no 836 0.224174905444276 1096 1114022 SGTC_2277 7947813 106.88 µM 0.757299118745675 0.246277013904051 no 837 0.224435339376914 1061 1246798 SGTC_815 1582-0027 36.9 µM 0.757128112541939 0.246328868813628 no 838 0.224486556559413 1115 3128206 SGTC_2912 7964298 10.93 µM 0.756954569656511 0.246381498914528 no 839 0.224538540270298 1127 2975850 SGTC_3212 9128307 49.47 µM 0.755775889385319 0.246739115001531 no 840 0.224891787415191 1003 27243542 SGTC_196 k015-0023 18.111 µM 0.755384427659669 0.246857947433166 no 841 0.225009177039367 1098 5211998 SGTC_1901 st060216 58.6 µM 0.754271025877512 0.247196099964684 no 842 0.225343248282296 1131 688792 SGTC_2254 7938975 95.19 µM 0.753894628249034 0.247310472119913 no 843 0.225456248202931 1134 2969277 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.750500772649981 0.24834300510707 no 844 0.22647657930867 1104 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_51 1013-0126 23.419 µM 0.750315661826222 0.248399388494419 no 845 0.226532306038051 1093 1627850 SGTC_281 1672-3440 14.9 µM 0.75016170830709 0.248446286793789 no 846 0.226578658905587 1133 6833000 SGTC_2857 9024691 58.44 µM 0.749536058017927 0.248636924905081 no 847 0.226767086978377 1115 16478292 SGTC_2058 5236698 133 µM 0.749283524076983 0.248713895059108 no 848 0.226843168057898 1088 766665 SGTC_1919 st067113 52.3 µM 0.748887377015138 0.248834662806501 no 849 0.226962544570345 1067 1268243 SGTC_1914 st062367 72.6 µM 0.747721284957042 0.249190333902142 no 850 0.2273141448889 1062 978205 SGTC_1840 st055363 71 µM 0.747365748555483 0.249298830233207 no 851 0.227421407318965 1078 676033 SGTC_1637 st007924 17.4 µM 0.746823912048426 0.249464226637909 no 852 0.227584929791419 1111 683336 SGTC_2723 salbutamol 83.58 µM 0.746421860067307 0.249586991285078 no 853 0.227706309046505 1066 9884233 β2-adrenoceptor agonist SGTC_2699 st077704 54.6 µM 0.745888854961683 0.249749791306012 no 854 0.227867279134026 1104 645852 SGTC_1316 1272-0050 65.9 µM 0.743601798857988 0.250448984761806 no 855 0.228558707320599 1120 7340392 SGTC_1591 genipin 88.4 µM 0.74250727997353 0.250783965179736 no 856 0.2288900213288 1070 442424 A DNA cross-linking agent. SGTC_691 1548-0686 185 µM 0.742008204106965 0.25093678738612 no 857 0.229041182451507 1122 46495133 SGTC_2704 st078022 71.1 µM 0.741426123147421 0.251115088857877 no 858 0.229217555056115 1129 54697681 SGTC_2268 7933382 153.85 µM 0.74098401715609 0.251250558342067 no 859 0.229351565620808 1192 935025 YOR257W CDC31 SGTC_963 1269-2853 151 µM 0.738674870330765 0.251958751369268 no 860 0.23005222436729 1116 3668223 SGTC_847 0342-0274 5.54 µM 0.73848130172709 0.252018164807768 no 861 0.230111012773496 1156 18097 SGTC_960 1222-0186 7.7 µM 0.738266944556619 0.252083967659071 no 862 0.230176124648069 1117 3126296 SGTC_2752 diclazuril 33.15 µM 0.73665598081496 0.252578787334372 no 863 0.230665791168661 1215 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1358 1509-0022 2.48 µM 0.734880182784173 0.253124829423383 no 864 0.231206234219197 1153 3258434 SGTC_774 k060-0086 136 µM 0.732324649098067 0.253911721680545 no 865 0.231985218953163 1181 5911235 SGTC_2936 9038235 15.59 µM 0.731486225593385 0.254170165940565 no 866 0.232241107507974 1147 4749415 SGTC_2606 farnesol 9.78 µM 0.730702165965365 0.254411977292288 no 867 0.232480546143979 1140 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3298 9116858 71.43 µM 0.730350878929431 0.254520356609467 no 868 0.232587867817574 1150 2506942 SGTC_668 1682-0499 62.6 µM 0.729979932065572 0.254634827642072 no 869 0.232701225656646 1164 682214 SGTC_3228 9131799 49.47 µM 0.729487165431764 0.254786932905223 no 870 0.232851857937175 1083 17015818 SGTC_2300 7976697 71.57 µM 0.729336130006029 0.254833563447564 no 871 0.232898038325242 1047 2236109 SGTC_779 1360-0071 233 µM 0.729306342289406 0.254842760607939 no 872 0.232907146777926 1217 7566 SGTC_2963 9082507 9 µM 0.72683477262189 0.255606479436201 no 873 0.233663589411943 1129 16459611 SGTC_1056 3448-1962 115 µM 0.726475183898916 0.255717692430012 no 874 0.233773757654787 1116 715507 SGTC_1111 tnp00062 510.699 nM 0.725167572305948 0.256122321216757 no 875 0.234174617012654 1198 676306 SGTC_1870 st057514 26.5 µM 0.725150812257456 0.256127509631258 no 876 0.234179757415896 1158 5393161 SGTC_1103 duloxetine 36.1 µM 0.724805094409423 0.256234545860589 no 877 0.234285805002361 1216 60835 A selective serotonin reuptake inhibitor. SGTC_2033 5192550 145 µM 0.722425941456466 0.256971777232432 no 878 0.235016321231003 1147 182073 SGTC_1208 2323-2347 50.3 µM 0.721685861490621 0.25720133163874 no 879 0.235243818295672 1157 5412760 SGTC_2838 9002687 71.43 µM 0.721396512106738 0.257291109604593 no 880 0.235332795972998 1132 6457060 SGTC_401 neomycin 50 µM 0.721074022692672 0.257391189293041 no 881 0.235431986411179 1115 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1915 st067105 30.6 µM 0.719471934660479 0.257888672653398 no 882 0.235925094260282 1178 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2760 etidronate 98.04 µM 0.718857373583181 0.258079639615145 no 883 0.236114401419491 1169 3305 A chelator and antioxidant. SGTC_2229 7354935 190 µM 0.715708403913711 0.259059290794491 no 884 0.237085710262056 1126 318112 SGTC_1184 1269-1718 139 µM 0.713705287372001 0.259683463788377 no 885 0.237704718118623 1181 5403821 SGTC_97 0535-0701 19.132 µM 0.713273393308331 0.259818144037939 no 886 0.23783829915113 1131 2832013 YGL099W LSG1 SGTC_1392 3455-1037 33.9 µM 0.712568205077933 0.260038124767724 no 887 0.238056496120549 1173 981132 SGTC_1632 st005650 90 µM 0.712446174507526 0.260076201475188 no 888 0.238094265541632 1152 2759605 SGTC_3256 9138902 49.47 µM 0.711351359029299 0.260417940875459 no 889 0.238433266396841 1197 17228773 SGTC_3017 9080681 49.47 µM 0.711243274954625 0.260451691142672 no 890 0.238466748093578 1154 16451914 SGTC_2355 9061122 103.12 µM 0.708986186674752 0.261157002488637 no 891 0.239166524444961 1162 5302957 SGTC_3079 9117512 49.47 µM 0.707917819749826 0.261491195502339 no 892 0.239498146471427 1207 7185044 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.707882572841995 0.261502224734013 no 893 0.239509091418849 1142 5711223 A potent inhibitor of glutathione S-transferases. SGTC_842 0271-0008 11.1 µM 0.706891328282193 0.261812496268517 no 894 0.239817006668655 1198 1221709 SGTC_2794 7785382 27.27 µM 0.705562068234432 0.262228866935919 no 895 0.24023026011098 1185 2205081 SGTC_2890 9046729 58.44 µM 0.703340794729203 0.262925403669607 no 896 0.240921696678352 1115 903329 SGTC_1722 st034304 3.6505 µM 0.70298437765603 0.263037255295863 no 897 0.24103274264747 1206 4036148 YLR033W RSC58 SGTC_2480 5767542 37.17 µM 0.702240802085745 0.263270684157893 no 898 0.241264502016609 1189 2867358 SGTC_165 k038-0023 64.381 µM 0.702098915887833 0.263315238162445 no 899 0.241308739192721 1198 46368543 SGTC_225 nsc-122657 1.016 µM 0.702025720171767 0.263338224019498 no 900 0.241331561823303 1112 275685 SGTC_705 1124-0212 310 µM 0.701542033581105 0.263490143234359 no 901 0.241482406143657 1193 9554485 SGTC_3275 9138069 49.47 µM 0.7012060729543 0.263595690102467 no 902 0.241587210218589 1180 17617007 SGTC_1347 1493-0251 600 nM 0.698801425053709 0.264351774116513 no 903 0.242338068921162 1200 3986378 SGTC_1366 1683-0113 21.9 µM 0.698559744862557 0.264427825683849 no 904 0.242413604177125 1206 708623 SGTC_1559 coumarin 343 70.1 µM 0.69736418900104 0.264804205171119 no 905 0.242787453372398 1204 108770 A hepatotoxic, DNA x-linker. SGTC_1131 3454-3128 32.3 µM 0.695994050928703 0.265235880507288 no 906 0.243216277692548 1230 710982 SGTC_1014 4130-3005 69.3 µM 0.694981604721144 0.265555090934637 no 907 0.24353341488203 1225 743608 SGTC_508 roscovitine 141 µM 0.694473405648819 0.265715392567724 no 908 0.243692686582757 1219 160355 A CDKinase inhibitor. SGTC_222 nsc-310342 10.666 µM 0.693809383206269 0.265924919593539 no 909 0.243900878694478 1163 432556 SGTC_3198 9112019 49.47 µM 0.693712779460647 0.26595540911466 no 910 0.243931175029918 1233 45595555 SGTC_552 k242-0005 476 µM 0.693438329325437 0.266042039157053 no 911 0.244017257649508 1205 4088318 SGTC_2215 7188065 200 µM 0.692035725644904 0.266484993331564 no 912 0.244457446873818 1205 940217 SGTC_1285 0929-0069 65.5 µM 0.691963594379761 0.266507783080212 no 913 0.244480095909767 1198 1206237 SGTC_2087 5276107 200 µM 0.691824360368214 0.266551776613396 no 914 0.244523818236563 1193 144405 SGTC_2416 tofa 880 nM 0.690470206103425 0.26697983789397 no 915 0.244949269976933 1134 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1289 0976-0073 69.1 µM 0.688454444163358 0.267617682205469 no 916 0.245583324383809 1237 3391136 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.68703271986368 0.268068017636755 no 917 0.24603105489531 1188 6708760 SGTC_1134 3477-0009 42.5 µM 0.686250879451768 0.26831583039879 no 918 0.246277459178774 1249 3973534 SGTC_1988 st071872 53.4 µM 0.685524729945752 0.268546094494613 no 919 0.246506430403541 1220 16414116 SGTC_2786 7743617 45.45 µM 0.681297133722954 0.269888646859783 no 920 0.247841748291366 1146 583674 SGTC_3022 9087993 49.47 µM 0.681221882932891 0.269912574557923 no 921 0.247865551743328 1234 17173644 SGTC_672 1441-0018 53.7 µM 0.679047199375505 0.270604523012447 no 922 0.248553978069352 1204 251141 SGTC_1122 capsaicin 818.572 nM 0.677925549122935 0.270961759651473 no 923 0.248909449854038 1255 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2149 5554786 194.827 µM 0.677853968263302 0.27098456556767 no 924 0.248932144338481 1255 745063 YPR165W RHO1 SGTC_2512 diallyl trisulfide 49.23 µM 0.677547191164005 0.271082316686798 no 925 0.24902941951658 1233 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3182 9108849 49.47 µM 0.676416433185166 0.271442771977529 no 926 0.249388143310285 1244 17133045 SGTC_14 0354-0009 295 µM 0.67579895725239 0.271639707475326 no 927 0.249584148422748 1262 1713507 SGTC_2720 fluspirilene 36.88 µM 0.673322930129966 0.272430116278865 no 928 0.250370933942273 1204 3396 An atypical antipsychotic. SGTC_3173 9105693 49.47 µM 0.672644130030657 0.272647005305586 no 929 0.250586859718505 1282 17096658 SGTC_2872 9044037 25.97 µM 0.67254688730545 0.272678083148408 no 930 0.250617800629297 1223 6465195 SGTC_2310 7668677 200 µM 0.672234905940019 0.272777801268227 no 931 0.25071708122742 1264 2197143 SGTC_1874 staurosporine 7.6 µM 0.671465568460342 0.273023780701673 no 932 0.250961993435296 1243 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2194 5927483 104.545 µM 0.67110635513444 0.273138669231559 no 933 0.251076389362525 1252 760979 SGTC_1699 st031318 29.054 µM 0.668996873268022 0.273813835697576 no 934 0.251748736255526 1269 5340658 SGTC_1888 azatryptophan 97.5 µM 0.668877322390348 0.273852124171571 no 935 0.251786868684771 1207 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_387 norethindrone acetate 66.7 µM 0.667532574874949 0.274282987766765 no 936 0.252216004756401 1232 541197 SGTC_209 4077-0173 175.592 µM 0.667206192988942 0.274387612555192 no 937 0.252320217939885 1185 15993494 SGTC_876 0720-0963 56.8 µM 0.666650099016909 0.274565919080009 no 938 0.252497830078822 1259 765861 SGTC_2123 5259487 200 µM 0.665170881249272 0.275040495013131 no 939 0.252970601357653 1223 2173474 SGTC_3123 9126162 49.47 µM 0.665056636374253 0.275077164882134 no 940 0.253007134413178 1299 25239884 SGTC_2188 6126565 140.678 µM 0.664462108019759 0.275268033108984 no 941 0.253197296606448 1204 874518 SGTC_1428 4049-0204 61.7 µM 0.661795890716144 0.276124800156315 no 942 0.254051020022548 1292 X1428 SGTC_3067 9117431 49.47 µM 0.661613835030362 0.276183349966844 no 943 0.254109369325306 1240 17150885 SGTC_1462 k081-0014 26.5 µM 0.661505098729356 0.276218322886781 no 944 0.254144222934541 1063 3270634 SGTC_1694 st024011 44.9 µM 0.660668349517408 0.276487519711032 no 945 0.254412512809848 1301 2787533 SGTC_1153 4055-0057 267 µM 0.660154097636579 0.276653027315079 no 946 0.254577472831977 1242 882706 SGTC_838 0109-0203 71.4 µM 0.657919420227478 0.277372802676382 no 947 0.255294955495453 1253 759422 SGTC_1092 toremifene 6.32 µM 0.656358799269377 0.27787601115101 no 948 0.255796646587334 1265 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3037 9091026 49.47 µM 0.653453110586443 0.278814110478578 no 949 0.256732104420246 1282 25236398 YIL048W NEO1 SGTC_2427 5545055 42.75 µM 0.653276021349827 0.27887133339297 no 950 0.256789174079007 1282 5372858 SGTC_2098 5376439 882.5 nM 0.653260037319065 0.278876498600251 no 951 0.2567943254972 1307 2844116 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.653230952603458 0.278885897386813 no 952 0.256803699211562 1281 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3308 9128332 17.569 µM 0.650276830944867 0.279841329930421 no 953 0.257756710107141 1286 17332805 YDL196W YDL196W SGTC_2370 9071495 200 µM 0.648888901495664 0.280290766558272 no 954 0.258205094453693 1220 21791103 SGTC_1299 1079-1439 3.74 µM 0.647670632405846 0.280685551989919 no 955 0.258599001301436 1242 323161 SGTC_530 4358-1714 28 µM 0.647231156789016 0.280828031973166 no 956 0.258741174691273 1296 1564641 SGTC_782 0083-0095 30.5 µM 0.646271943584732 0.281139134633499 no 957 0.259051627228405 1276 3591729 An indicator and reagent. SGTC_1617 st002906 78 µM 0.644185061622413 0.28181654979652 no 958 0.259727718306264 1290 5150859 SGTC_2635 hydroquinidine 100 µM 0.643561772683693 0.282019025800674 no 959 0.25992982286197 1293 442912 An experimental heart treatment. SGTC_472 calcifediol 10 µM 0.642726683459263 0.282290415095828 no 960 0.26020073180896 1282 5283731 A vitamin D metabolite. SGTC_148 3253-0744 288.01 µM 0.642619793204888 0.282325161616318 no 961 0.260235418277974 1245 6893655 SGTC_2320 7373003 200 µM 0.641417295351911 0.282716195997366 no 962 0.260625799495405 1267 5415828 SGTC_896 0964-0007 44.5 µM 0.641194986736511 0.282788515938746 no 963 0.260698003193033 1260 6756758 SGTC_2134 5324836 1.464 µM 0.640555039236628 0.282996748947317 no 964 0.260905909432683 1263 699272 SGTC_2055 5235184 200 µM 0.640223235980822 0.283104743632237 no 965 0.261013739283627 1288 2836034 SGTC_2075 5212009 200 µM 0.639831437182415 0.283232291009398 no 966 0.261141096059395 1241 780898 SGTC_2222 6885208 172.143 µM 0.638964427185464 0.283514638039054 no 967 0.261423036853147 1257 609514 SGTC_2286 7945697 125 µM 0.638513761124644 0.283661453416555 no 968 0.261569649531771 1240 1245733 SGTC_2295 7971645 200 µM 0.638293165454085 0.283733331068675 no 969 0.261641430075131 1308 2978226 YKL099C UTP11 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.635703542789373 0.284577770658493 no 970 0.262484833417232 1278 16486 A toxic proline analog. SGTC_87 0100-0052 35.5 µM 0.635080114720176 0.284781240893418 no 971 0.262688082749147 1351 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3317 9138495 8.753 µM 0.634804118738117 0.284871340759727 no 972 0.262778088361418 1277 17020139 SGTC_2949 9072542 2.23 µM 0.633661327578652 0.285244553643306 no 973 0.263150934111396 1302 16457352 SGTC_724 3910-0327 137 µM 0.632825780606553 0.285517574034645 no 974 0.263423709667102 1279 2885483 SGTC_1852 st056254 31.4 µM 0.63212736566018 0.285745881052609 no 975 0.263651827327904 1239 442583 SGTC_118 0083-0097 135.343 µM 0.630786019225571 0.286184601309132 no 976 0.264090222987454 1361 5207356 SGTC_2830 7992007 71.43 µM 0.630407711487454 0.286308393950855 no 977 0.264213933374596 1263 1952075 SGTC_1507 4075-3230 155 µM 0.630070378725637 0.286418799896443 no 978 0.264324269424061 1239 659771 SGTC_3167 9103034 49.47 µM 0.629077694464148 0.286743813592587 no 979 0.264649096302103 1302 5127859 SGTC_3035 9091303 49.47 µM 0.628986024358123 0.286773836020565 no 980 0.264679102899031 1316 25237002 SGTC_1100 amiodarone 5.07 µM 0.628671351729153 0.286876904248365 no 981 0.264782118612046 1330 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1301 naphtanilide LB 4.81 µM 0.626886434980015 0.28746186981115 no 982 0.265366839881305 1354 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2953 9074162 66.49 µM 0.626519447706964 0.287582211357148 no 983 0.265487142494391 1292 16451992 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.626154779553666 0.287701816008205 no 984 0.265606712275642 1323 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_119 0121-0043 24.815 µM 0.624982106295047 0.288086591165011 no 985 0.265991401097084 1342 1092378 SGTC_1621 st003705 32.4 µM 0.623757668705125 0.288488610104139 no 986 0.266393371900538 1320 24207032 SGTC_1389 3405-0187 19 µM 0.621693864891198 0.289166815429902 no 987 0.267071593270162 1269 799890 SGTC_3341 9147222 25.867 µM 0.621611278538414 0.289193970473851 no 988 0.267098751495323 1294 1939759 SGTC_3332 9141069 11.198 µM 0.620850536493566 0.289444164822403 no 989 0.267348984340098 1281 17332883 SGTC_2784 7567673 72.73 µM 0.62005280764366 0.289706632621993 no 990 0.267611510324262 1321 3471247 SGTC_92 0063-0024 660.874 µM 0.618640357096639 0.290171629193373 no 991 0.268076654667256 1327 3594437 SGTC_1863 st057641 20.1 µM 0.617356742439932 0.290594514427872 no 992 0.268499723820365 1306 3921635 SGTC_1333 1482-0047 286 µM 0.616734342018225 0.290799667214089 no 993 0.268704982801951 1291 3811116 SGTC_2799 7812892 81.82 µM 0.615775028653546 0.291116004255851 no 994 0.26902150529522 1328 20205235 SGTC_109 0132-0036 33.701 µM 0.615672581998544 0.291149795905264 no 995 0.269055318310248 1208 67274 A color developer. SGTC_521 r062-0005 13.8 µM 0.615003128587824 0.291370657709602 no 996 0.269276327148245 1273 2832033 SGTC_1596 piperlongumine 63 µM 0.614545590879101 0.291521650594528 no 997 0.269427427924925 1362 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_123 0083-0120 66.675 µM 0.612448186078417 0.292214285737932 no 998 0.270120634599663 1265 16001701 SGTC_1715 st032160 10.2275 µM 0.612174901454026 0.292304590061159 no 999 0.270211022696249 1278 5289825 SGTC_314 1671-0008 2.74 µM 0.61205895298972 0.29234290805743 no 1000 0.270249376883972 1253 3913060 SGTC_1628 st004252 77.7 µM 0.611620546253845 0.292487811358486 no 1001 0.270394420518128 1365 692968 SGTC_179 1273-0063 6.77 µM 0.611566005410952 0.292505840670185 no 1002 0.270412467674508 1285 3108139 SGTC_2213 7173844 200 µM 0.610677622558154 0.292799581938777 no 1003 0.270706511640705 1301 892728 SGTC_2657 nystatin 74.44 µM 0.610670795541635 0.292801839802602 no 1004 0.270708771918514 1332 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1161 k007-0610 110 µM 0.610363187099623 0.292903581936594 no 1005 0.270810624210707 1386 5843850 SGTC_1411 3909-8223 150 µM 0.610268404500003 0.292934934785642 no 1006 0.270842011550659 1326 X1411 SGTC_1029 k015-0030 64.7 µM 0.609808597279163 0.29308705512293 no 1007 0.270994302874618 1361 2208316 SGTC_1254 0550-0035 264 µM 0.608597370509503 0.293487946648983 no 1008 0.271395673909998 1362 15121435 SGTC_652 0437-0092 114 µM 0.606694143178254 0.294118388900579 no 1009 0.272026954859472 1295 3091274 SGTC_2924 9010168 62.78 µM 0.606159139067475 0.294295721132204 no 1010 0.27220454161522 1341 2993929 SGTC_1738 st035555 74 µM 0.60482867517107 0.294736930071726 no 1011 0.272646419223325 1339 5331140 SGTC_1959 st077091 55.8 µM 0.604321111136355 0.294905328988658 no 1012 0.272815086658841 1336 821356 YKL052C ASK1 SGTC_1779 st039427 55 µM 0.604069844541791 0.294988710288924 no 1013 0.272898603632004 1451 1124498 SGTC_806 3966-4455 5.86 µM 0.604012458775752 0.295007754931897 no 1014 0.272917679515716 1263 714982 SGTC_1579 chlormadinone acetate 49.4 µM 0.602979226042878 0.295350751265995 no 1015 0.273261254562427 1361 45114258 A steroidal progestin. SGTC_251 melphalan 456.522 µM 0.602875073753122 0.295385336281383 no 1016 0.273295899618899 1409 460612 A DNA alkylator. SGTC_919 tnp00227 403.569 nM 0.602359497868802 0.29555656686308 no 1017 0.273467432017358 1356 1269246 A methoxyflavone. YNL221C POP1 SGTC_2400 5203494 178.7 µM 0.601560484811964 0.295822021364824 no 1018 0.273733369385077 1295 6777674 SGTC_2884 9058502 51.95 µM 0.59741876173127 0.29719976951835 no 1019 0.275113915296636 1339 6471554 SGTC_2725 haloperidol 53.21 µM 0.595170888813065 0.297948752408272 no 1020 0.275864623663672 1308 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1499 4480-0877 67.3 µM 0.595007882560373 0.298003098929762 no 1021 0.275919100976561 1303 2861909 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.594665584787915 0.298117236206791 no 1022 0.276033515397908 1345 688798 SGTC_3274 9138298 49.47 µM 0.593021293094524 0.298665793474324 no 1023 0.276583451100948 1309 17015756 SGTC_1177 0983-0204 23.6 µM 0.592131102873732 0.298962963962806 no 1024 0.276881400401983 1371 766818 SGTC_330 1488-0319 80.1 µM 0.591833293658683 0.299062411010486 no 1025 0.276981113103517 1354 6846614 SGTC_3019 9081971 49.47 µM 0.591224811835214 0.299265647240205 no 1026 0.277184900074346 1423 16451803 SGTC_2522 biochanin a 4.94 µM 0.588872696410934 0.300051855139065 no 1027 0.277973337412196 1342 5280373 A possible chelator. SGTC_2726 cimetidine 79.27 µM 0.588678696542353 0.300116742385162 no 1028 0.278038415671634 1349 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1172 0370-0043 85 µM 0.588237445074602 0.300264351641811 no 1029 0.278186463434761 1404 376585 SGTC_2358 9037157 4 µM 0.588082981098315 0.300316031320417 no 1030 0.278238297945296 1393 2388925 SGTC_772 k072-0172 35.3 µM 0.587985626752204 0.300348605648939 no 1031 0.278270970214131 1274 5861980 SGTC_345 1362-0200 395 µM 0.587886825959896 0.300381665584185 no 1032 0.278304129824741 1334 1419823 SGTC_1814 st052110 31.539 µM 0.587218823881943 0.300605230251655 no 1033 0.278528375805519 1363 674163 SGTC_270 tamoxifen 5.46 µM 0.585475596107184 0.301189001296768 no 1034 0.279113985533841 1462 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1478 0453-0656 35.7 µM 0.585031116651241 0.301337929975639 no 1035 0.279263397079716 1368 5258496 SGTC_2483 5729050 27.16 µM 0.584738572590482 0.301435968794371 no 1036 0.279361756823662 1440 2865180 SGTC_3259 9138485 49.47 µM 0.583285090233631 0.301923279728723 no 1037 0.279850698925206 1469 17646153 SGTC_2833 9001315 45.46 µM 0.582487241020615 0.302190926057849 no 1038 0.280119266600505 1402 2989378 SGTC_2301 7769476 200 µM 0.581496810531786 0.302523323724455 no 1039 0.280452833607783 1416 977820 SGTC_3293 9120939 62.045 µM 0.581296042253944 0.302590723396792 no 1040 0.280520473772541 1391 934087 SGTC_677 0929-0063 136 µM 0.58079433472306 0.302759180430041 no 1041 0.280689536877344 1342 1539583 SGTC_1073 triclabendazole 3.09 µM 0.580696492740073 0.302792037472182 no 1042 0.280722512962535 1402 50248 An antihelmetic and likely tubulin inhibitor. SGTC_753 1322-0200 289 µM 0.577541672448545 0.303852335700344 no 1043 0.281786798023776 1371 5403907 SGTC_1067 clotrimazole 1.36 µM 0.577476828740098 0.303874146274092 no 1044 0.281808693562141 1376 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_226 1,3-diallylurea 8.28947 mM 0.577302457584213 0.303932800530886 no 1045 0.281867576900658 1343 74537 YKL182W FAS1 SGTC_1928 4'-methoxychalcone 40.3 µM 0.576283113749198 0.304275784214674 no 1046 0.282211917361394 1505 641818 SGTC_2715 st079500 56.4 µM 0.575194363912975 0.304642311534362 no 1047 0.282579927049361 1331 28246688 SGTC_1243 0416-0003 5.65 µM 0.573874034553073 0.305087063279067 no 1048 0.283026522496396 1360 2141977 SGTC_152 4469-0003 551.229 µM 0.573847024415481 0.305096164627789 no 1049 0.283035662088665 1373 697280 SGTC_2875 9039966 71.43 µM 0.573407860451249 0.30524416243486 no 1050 0.283184284669548 1489 6463691 SGTC_1143 3454-2408 5.08 µM 0.571173747737633 0.305997548829063 no 1051 0.283940935866312 1329 X1143 SGTC_511 blebbistatin 171 µM 0.569584802477849 0.306533872298333 no 1052 0.284479669279605 1446 3476986 A myosin inhibitor. SGTC_3066 9117245 49.47 µM 0.568526938860911 0.306891167509933 no 1053 0.284838609494006 1477 17176980 SGTC_575 k072-0246 11.9 µM 0.565774810143414 0.307821562710074 no 1054 0.285773436195205 1399 6796779 SGTC_308 4092-1169 104 µM 0.564231403674994 0.308343874435537 no 1055 0.286298329172401 1393 2268590 YDL196W YDL196W SGTC_2241 6772625 37.8075 µM 0.562198753892456 0.30903234562544 no 1056 0.286990305169829 1332 2285411 SGTC_448 monastrol 171 µM 0.562003474043135 0.309098523515122 no 1057 0.287056826076816 1389 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1497 4476-2978 41.3 µM 0.561735970406821 0.309189187195731 no 1058 0.287147961433031 1405 1528379 SGTC_1420 4'-methoxyflavone 42 µM 0.56037946459085 0.309649119776291 no 1059 0.287610317800848 1403 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2343 7990716 14.84 µM 0.560297588416368 0.30967689000379 no 1060 0.287638236030643 1432 6456862 SGTC_1450 4112-4260 37.6 µM 0.559982483444253 0.309783775390837 no 1061 0.287745692825896 1405 1633175 SGTC_2062 5245942 200 µM 0.558513015763082 0.31028243941212 no 1062 0.288247059578692 1443 1376160 SGTC_384 k007-0144 5.16 µM 0.558148843811446 0.310406075202918 no 1063 0.288371374856299 1423 6824886 SGTC_845 0330-0138 4.51 µM 0.557828449223022 0.310514866367021 no 1064 0.288480767005384 1419 9039800 SGTC_2656 pseudo-anisatin 100 µM 0.556539284452554 0.310952774474508 no 1065 0.288921123366712 1395 6708809 A neurotoxin. SGTC_613 3914-0030 117 µM 0.555791021087866 0.311207070144983 no 1066 0.28917686216897 1290 1145395 SGTC_1831 st055328 12 µM 0.555150717826047 0.311424747385083 no 1067 0.289395787216452 1445 1103068 SGTC_41 0478-0632 82.643 µM 0.554234840694038 0.3117362232145 no 1068 0.289709068552246 1417 3750424 SGTC_507 nimesulide 162 µM 0.553057540055356 0.312136803075228 no 1069 0.290112005010331 1461 4495 A COX2 inhibitor. SGTC_1047 2043-3044 82 µM 0.552992609096571 0.312158902487135 no 1070 0.290134235563976 1365 669592 SGTC_416 estradiol valerate 100 µM 0.552559282022609 0.312306403730002 no 1071 0.290282615133315 1414 13791 A steroid. SGTC_957 1187-1561 14.1 µM 0.550605408949716 0.312971860657047 no 1072 0.29095210008445 1390 1538454 SGTC_189 3970-0742 2.116 µM 0.550251888208452 0.313092329197232 no 1073 0.291073309259465 1433 2891807 SGTC_1515 3460-0031 42.1 µM 0.549112927645605 0.313480586115752 no 1074 0.291463976985346 1370 2876596 SGTC_903 1134-0042 114 µM 0.548407869402085 0.313721034989216 no 1075 0.291705937095658 1407 701009 SGTC_1059 3448-6867 171 µM 0.548088264732166 0.313830057143845 no 1076 0.291815649048185 1405 3934407 SGTC_755 1995-0008 37.3 µM 0.54643101935127 0.314395629998064 no 1077 0.292384846234307 1404 689533 SGTC_1751 st044839 27.194 µM 0.545512800874313 0.314709180812034 no 1078 0.292700439463018 1428 5291326 SGTC_2160 5660466 132.927 µM 0.545478427325888 0.314720921196877 no 1079 0.29271225678077 1395 2859134 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.544838012459683 0.314939690986618 no 1080 0.292932466179751 1418 616764 SGTC_377 3970-0964 33.1 µM 0.544795280714603 0.314954290734569 no 1081 0.292947162409278 1457 16481235 SGTC_85 0868-0259 160.055 µM 0.544031963168221 0.315215134860175 no 1082 0.293209738912366 1445 83173 SGTC_849 0386-0493 241 µM 0.54273146052891 0.315659760366725 no 1083 0.293657354897635 1378 726119 SGTC_1993 st073995 70.8 µM 0.542372549244756 0.315782514652788 no 1084 0.293780943133648 1450 3098394 SGTC_621 3584-0052 32.1 µM 0.539946358165142 0.316612849247068 no 1085 0.294617013153874 1448 2273927 SGTC_729 4092-0585 94.1 µM 0.539944687531906 0.316613421320263 no 1086 0.294617589235233 1385 2169061 SGTC_482 fipronil 114 µM 0.539695450940449 0.316698772059754 no 1087 0.294703538847719 1450 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_117 lucigenin 22.078 µM 0.537970003253431 0.317289916773369 no 1088 0.29529887895396 1381 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1942 st076330 65.2 µM 0.535192786184201 0.318242380669405 no 1089 0.296258277038392 1453 24208414 SGTC_2326 6164455 177.58 µM 0.534595318745793 0.318447443301354 no 1090 0.296464860689075 1428 2888790 SGTC_386 1509-0011 3.07 µM 0.53370685843466 0.318752483301113 no 1091 0.296772181665631 1429 3107280 SGTC_1447 4239-0816 81.9 µM 0.531724429925803 0.319433564092535 no 1092 0.297458434595696 1382 1341554 SGTC_37 0566-0070 1.56 µM 0.530882499466099 0.319723001297259 no 1093 0.297750102890892 1499 1626686 SGTC_2727 riluzole 51.77 µM 0.530828326611111 0.319741628497492 no 1094 0.29776887435189 1439 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2224 6650123 117.647 µM 0.528898088746634 0.32040563235219 no 1095 0.298438073948194 1427 2908370 SGTC_359 0081-0058 15.9 µM 0.527088953075184 0.321028499363782 no 1096 0.299065908870911 1598 3494159 SGTC_82 0054-0107 293.755 µM 0.524918185415782 0.321776537660304 no 1097 0.299820033459653 1493 3104697 SGTC_402 epigallocatechin gallate 10 µM 0.524486705811359 0.321925310122967 no 1098 0.299970031971896 1432 65064 An antioxidant. SGTC_728 3030-5151 22.5 µM 0.524194615462999 0.322026037926189 no 1099 0.300071592815842 1478 3125388 SGTC_1989 st071868 50.2 µM 0.52315057254303 0.322386184581581 no 1100 0.300434737313291 1525 16414057 SGTC_260 nsc-65238 3.989 µM 0.522574485495978 0.322584979463861 no 1101 0.300635199897569 1484 3246252 SGTC_2673 kobusone 100 µM 0.521963658459121 0.322795817757794 no 1102 0.300847816977442 1508 6710676 An epoxy ketone and protein crosslinker. SGTC_2020 4017018 200 µM 0.521521741528717 0.322948389116697 no 1103 0.301001681987897 1443 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1180 1193-0155 285 µM 0.521459156260025 0.322969999024924 no 1104 0.30102347556392 1420 2921347 SGTC_328 k915-0120 63.5 µM 0.52121635866599 0.32305383964457 no 1105 0.301108029792445 1517 6624543 SGTC_466 geldanamycin 89.2 µM 0.520219664402776 0.323398103060101 no 1106 0.301455240519789 1398 5288382 HSP90 inhibitor. SGTC_777 1315-0167 517 µM 0.519806738748153 0.323540774071519 no 1107 0.301599141030138 1407 4221767 SGTC_274 sirtinol 40.1 µM 0.519376149880214 0.323689575578394 no 1108 0.301749229896159 1408 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2304 7443016 91.4 µM 0.518565071839326 0.32396994185102 no 1109 0.302032035705704 1430 939854 SGTC_1864 st057645 30.4 µM 0.515496941641811 0.325031408424854 no 1110 0.303102903099324 1472 688666 SGTC_914 3820-6779 408 µM 0.514708088097667 0.325304554490052 no 1111 0.303378510344857 1417 2893481 SGTC_829 1635-0120 117 µM 0.513615346183985 0.325683079105369 no 1112 0.303760474064086 1562 285054 SGTC_727 3032-0951 202 µM 0.512933097123082 0.32591950064333 no 1113 0.303999060348 1477 3652836 SGTC_719 2810-4230 27.3 µM 0.509939990368543 0.326957535954504 no 1114 0.305046752105718 1476 721079 SGTC_2452 5863136 48.41 µM 0.509689144976477 0.327044592288689 no 1115 0.305134629517876 1421 2184096 SGTC_2873 9040596 71.43 µM 0.509335205966556 0.327167443453074 no 1116 0.305258642312704 1449 6463863 SGTC_1502 4534-4282 27.7 µM 0.50911028130981 0.327245523856886 no 1117 0.305337462807646 1469 3278949 SGTC_2174 5790901 200 µM 0.508875365171655 0.327327080777482 no 1118 0.30541979426064 1458 786020 SGTC_1925 st057770 10.1 µM 0.507925796605078 0.32765683085318 no 1119 0.305752691417696 1381 5989122 SGTC_502 l-744,832 89.3 µM 0.505326416488589 0.328560186741805 no 1120 0.306664795884506 1535 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.505168447171351 0.328615117791507 no 1121 0.306720264912 1373 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_917 harmaline 728.087 nM 0.50422291021894 0.328943989021022 no 1122 0.307052371360229 1523 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1157 4092-0394 27.6 µM 0.502562939480354 0.329521670808562 no 1123 0.307635795489619 1574 3659885 SGTC_582 0987-0078 156 µM 0.501232684499608 0.32998490304202 no 1124 0.30810368707901 1473 1625765 SGTC_1197 1601-0112 267 µM 0.497830507052577 0.331170822183136 no 1125 0.309301755786051 1447 7350313 SGTC_1380 2291-0730 164 µM 0.493460028344455 0.332696755532559 no 1126 0.310843788203703 1460 2999191 SGTC_1000 4048-0884 8.67 µM 0.492383423278324 0.33307307453457 no 1127 0.311224157809994 1526 13040088 SGTC_132 0417-1715 25.805 µM 0.492268172929442 0.333113369376106 no 1128 0.311264888254279 1614 6769098 SGTC_2877 9040724 71.43 µM 0.489804626571663 0.333975156255851 no 1129 0.312136078261665 1581 6463895 SGTC_2214 7179297 48.276 µM 0.489171774369908 0.334196679455901 no 1130 0.312360045326991 1540 769744 SGTC_2698 st077697 67.5 µM 0.488769491864902 0.334337524215499 no 1131 0.3125024495867 1445 3154499 SGTC_1460 k062-0059 9.15 µM 0.488264426471114 0.334514387733022 no 1132 0.312681277678352 1463 1373085 SGTC_3158 9100007 49.47 µM 0.488102247593331 0.334571187234795 no 1133 0.312738709577922 1477 19297233 SGTC_305 1682-2595 20.8 µM 0.487352534953867 0.334833806403531 no 1134 0.313004262043222 1524 226033 SGTC_622 1348-1566 26.3 µM 0.484150909985559 0.335956221501333 no 1135 0.314139386451841 1587 7340407 SGTC_1482 3346-2049 8.48 µM 0.483581430797532 0.336156021334038 no 1136 0.314341477930381 1533 3826804 SGTC_1440 4100-1550 40 µM 0.483399551765306 0.336219842729313 no 1137 0.31440603319974 1520 742806 SGTC_1329 1447-1697 50.6 µM 0.483013314568097 0.336355389107737 no 1138 0.314543141196771 1485 2840515 SGTC_190 3970-0790 3.722 µM 0.480303636680014 0.337306922824019 no 1139 0.315505751667723 1560 2832352 SGTC_367 0335-0881 7.1 µM 0.480047012949752 0.337397093203169 no 1140 0.315596982071922 1573 23828853 SGTC_3110 9122132 49.47 µM 0.477578291324779 0.338265009115916 no 1141 0.316475192496151 1592 918317 SGTC_2521 angolensin 13.4 µM 0.476046437768253 0.338803987840015 no 1142 0.317020647399611 1551 821428 A flavenoid. SGTC_2074 5212007 75.395 µM 0.474666737722918 0.339289714444298 no 1143 0.317512264842393 1575 758611 SGTC_1629 st005085 44.9 µM 0.474584937003204 0.339318520974965 no 1144 0.317541422356864 1456 24207091 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.472483603547412 0.340058837504436 no 1145 0.318290821222491 1561 65057 A dermal irritant. YDR527W RBA50 SGTC_1496 4469-0713 57.4 µM 0.472347928331949 0.34010665820261 no 1146 0.318339232705909 1590 746691 SGTC_1362 1611-0397 101 µM 0.472089173134922 0.340197867356328 no 1147 0.318431570055533 1513 27816 SGTC_3147 9097027 49.47 µM 0.471985785102555 0.340234313432275 no 1148 0.318468467451916 1634 25236841 SGTC_2908 7930301 100 µM 0.471449571575513 0.340423361946651 no 1149 0.31865986164254 1419 2223178 SGTC_376 3970-0862 59.1 µM 0.468935333666311 0.341310320939901 no 1150 0.319557929660073 1617 3135186 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.468487511042115 0.341468393526595 no 1151 0.319718000023092 1497 803109 SGTC_1147 3809-1045 12.3 µM 0.468325943060458 0.341525430678171 no 1152 0.319775759360793 1490 325925 SGTC_1733 st037357 54.9 µM 0.46763533365856 0.341769272199886 no 1153 0.320022696278793 1436 1272339 YGL099W LSG1 SGTC_962 1254-0300 21.5 µM 0.46665362894031 0.342116007774966 no 1154 0.320373855597905 1543 7340576 SGTC_1313 1220-0047 237 µM 0.465197603150966 0.342630517498586 no 1155 0.320894977503815 1588 3528706 SGTC_2537 larixol 68.93 µM 0.464653347911839 0.34282291373878 no 1156 0.321089861001961 1592 6708759 SGTC_1218 1348-1416 30.7 µM 0.463819962782378 0.343117597464304 no 1157 0.321388369823001 1535 6787668 SGTC_1165 k072-0275 30.3 µM 0.462959766801711 0.343421861559036 no 1158 0.321696603013023 1531 6153523 YGL055W OLE1 SGTC_462 ag-879 158 µM 0.462020720335373 0.343754132123446 no 1159 0.322033230785809 1610 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2769 toremifene 3.73 µM 0.459114212183828 0.344783330094265 no 1160 0.32307607563098 1565 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2546 rhodinyl acetate 100 µM 0.458498340414909 0.345001558891835 no 1161 0.323297227273012 1632 6708682 SGTC_1127 asiatic acid 681.4 nM 0.456838172017873 0.345590081781047 no 1162 0.323893683335427 1511 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1071 trifluoperazine 6.31 µM 0.456494802436776 0.34571185153856 no 1163 0.324017103768969 1629 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1250 0485-0349 40.2 µM 0.455538717216737 0.346050993794087 no 1164 0.32436086002404 1531 6842794 YDL195W SEC31 SGTC_1495 4469-0029 237 µM 0.453891187786206 0.346635694625897 no 1165 0.324953573237985 1524 793680 SGTC_1354 1498-1681 81 µM 0.453800554041963 0.346667870756465 no 1166 0.324986192403862 1566 5754243 SGTC_3249 9135183 49.47 µM 0.453087548299359 0.346921035414729 no 1167 0.325242850586435 1578 4902779 SGTC_1266 0828-0227 32.9 µM 0.452661407312249 0.347072376567472 no 1168 0.325396286666169 1596 3913820 SGTC_1408 3909-7976 48.8 µM 0.452172107655684 0.34724617818931 no 1169 0.325572500124934 1579 24152374 SGTC_1958 st076513 41.9 µM 0.451810821689025 0.347374529347148 no 1170 0.325702636523032 1498 732122 YGL099W LSG1 SGTC_3107 9121808 49.47 µM 0.450583408943192 0.347810713065775 no 1171 0.326144913253273 1562 662681 SGTC_1951 sophoraflavanone G 9.2 µM 0.449461173158073 0.348209696581302 no 1172 0.326549505436542 1524 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1387 3342-1166 1.8 µM 0.447186519029951 0.349018909426968 no 1173 0.327370197075826 1573 3418228 SGTC_2287 7945887 168.79 µM 0.445829825013414 0.349501883459373 no 1174 0.327860088008881 1621 1245853 SGTC_1931 st074438 57.1 µM 0.445427743822675 0.349645068542512 no 1175 0.328005333156763 1516 2787313 SGTC_1175 0741-0056 27.6 µM 0.445320281691255 0.349683340492294 no 1176 0.328044156472238 1659 765927 SGTC_409 arachidonic acid 100 µM 0.445158165386983 0.349741080066283 no 1177 0.328102728455918 1567 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_140 0062-0056 502.533 µM 0.444246128819236 0.350065977053407 no 1178 0.328432322433067 1465 3758964 SGTC_853 0419-0306 21 µM 0.443896473285447 0.350190564813293 no 1179 0.32855871722568 1502 762713 SGTC_2092 5303694 80.6725 µM 0.442777260203031 0.350589466370642 no 1180 0.328963426411111 1540 1963699 SGTC_1052 3253-3998 198 µM 0.442620608995902 0.35064531198018 no 1181 0.329020087743854 1531 5450317 SGTC_1043 0916-0009 19.3 µM 0.441869987170306 0.350912950814442 no 1182 0.329291644987656 1757 3101130 SGTC_1050 3232-1156 69.3 µM 0.44043048529398 0.351426420976763 no 1183 0.329812674687352 1525 700529 SGTC_835 0312-0010 67.2 µM 0.440159701751829 0.351523039776547 no 1184 0.329910722117619 1561 1626196 SGTC_2682 pyrogallin 40.03 µM 0.44015848352985 0.351523474474371 no 1185 0.329911163247406 1587 822798 An ATP competetive kinase inhibitor. SGTC_1021 4476-0760 85.3 µM 0.437062494419016 0.35262884134247 no 1186 0.331033013128437 1536 746768 SGTC_2900 5328528 85.29 µM 0.436594620529 0.352795995804423 no 1187 0.331202682328424 1516 795359 SGTC_1963 st076565 50.3 µM 0.436419465275015 0.352858579770732 no 1188 0.331266209328448 1559 4914280 SGTC_198 3454-2873 16.191 µM 0.435600971195771 0.35315108510071 no 1189 0.331563133013205 1589 710957 SGTC_2907 7721985 69.9 µM 0.435524409898668 0.35317845026205 no 1190 0.331590912440662 1522 3267881 SGTC_2258 7960471 200 µM 0.434971556512003 0.353376078142949 no 1191 0.331791536718803 1534 2974708 SGTC_2826 7992541 19.48 µM 0.434880266752236 0.353408715196114 no 1192 0.331824669389088 1629 2985066 SGTC_862 0452-0056 10.2 µM 0.434828676022585 0.353427159903509 no 1193 0.331843394290408 1551 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2563 tomatine 8.54 µM 0.434444711328655 0.353564445696187 no 1194 0.331982767812668 1818 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1893 st059353 36.1 µM 0.434102881767334 0.353686682188308 no 1195 0.33210686646738 1538 3112488 SGTC_2969 9091408 28.7 µM 0.43086324935266 0.354845905557119 no 1196 0.333283903370579 1505 4286311 SGTC_370 0180-0345 38.7 µM 0.430326860992391 0.355037969126223 no 1197 0.33347894516339 1550 3989527 SGTC_300 r073-0011 5.04 µM 0.429907233638893 0.35518824998833 no 1198 0.333631561655554 1606 2735780 SGTC_789 1309-1135 70.6 µM 0.429691119245701 0.355265655680224 no 1199 0.333710172185936 1540 3092424 SGTC_3070 9117005 49.47 µM 0.4290723329553 0.355487319384355 no 1200 0.333935292971691 1647 8779016 SGTC_3125 9127534 49.47 µM 0.427196206480385 0.356159690274636 no 1201 0.33461821207897 1554 1639235 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.426527482755236 0.356399457444506 no 1202 0.334861763219286 1609 688801 SGTC_1509 1326-1131 80 µM 0.425812725455772 0.35665579246649 no 1203 0.335122156736445 1671 768313 SGTC_2695 st077686 51.995 µM 0.423817607651066 0.357371648383778 no 1204 0.335849417971227 1544 2876092 SGTC_1758 st042942 75.2445 µM 0.422091397429481 0.35799142459426 no 1205 0.336479153395964 1592 669317 SGTC_2658 polymyxin b sulfate 77.05 µM 0.420468526604507 0.358574439548224 no 1206 0.337071608411749 1584 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2282 7944268 200 µM 0.419658784125601 0.358865462242155 no 1207 0.337367369199131 1673 2970414 SGTC_2612 dictamnine 15.46 µM 0.419284953808335 0.358999845092703 no 1208 0.337503945731593 1596 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3206 9114350 49.47 µM 0.418747652896034 0.359193022183967 no 1209 0.337700282702296 1565 17087243 SGTC_541 4513-1321 94 µM 0.418572458434012 0.35925601805711 no 1210 0.337764310665511 1555 747515 SGTC_1168 k815-0004 80.5 µM 0.418263716691338 0.359367043753466 no 1211 0.33787715730889 1571 642433 SGTC_1837 st055472 66.5 µM 0.41731835276435 0.359707077065835 no 1212 0.338222783121356 1658 676091 SGTC_1771 st048882 4.1505 µM 0.415153515202381 0.360486154946372 no 1213 0.339014762803395 1526 4580403 SGTC_153 4077-0274 519.67 µM 0.414868758218977 0.360588675979709 no 1214 0.339118990768132 1726 3121976 SGTC_1391 3442-0225 151 µM 0.409394926982388 0.362561358985158 no 1215 0.341124930976502 1627 5227075 SGTC_1807 st050092 58.9 µM 0.408624457159121 0.362839318806024 no 1216 0.341407639798649 1581 5008496 SGTC_1244 0416-0015 52.5 µM 0.406943208330635 0.36344610810822 no 1217 0.342024850024213 1608 96201 SGTC_877 0771-0151 33.1 µM 0.405688467261629 0.363899187480194 no 1218 0.34248575857078 1637 6166523 SGTC_2338 7999974 200 µM 0.405313644681241 0.364034570587771 no 1219 0.342623489046889 1784 315925 SGTC_1312 1218-2183 165 µM 0.404511075999103 0.36432450943736 no 1220 0.342918467369552 1637 6744073 SGTC_776 4476-4378 112 µM 0.404484098111659 0.364334256915982 no 1221 0.342928384562027 1599 2892008 SGTC_352 k048-0007 5.11 µM 0.403600188696044 0.364653673940561 no 1222 0.343253373452666 1604 6811911 SGTC_2539 epi(13)torulosol 80 µM 0.403104372524074 0.364832887449858 no 1223 0.343435722038881 1572 6708597 SGTC_1737 st035557 69.7 µM 0.401753081215333 0.365321463591266 no 1224 0.343932877562621 1574 5716916 SGTC_422 cantharidin 155 µM 0.401205989439095 0.365519333640367 no 1225 0.344134235703325 1550 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.400402935125429 0.365809844054927 no 1226 0.344429881376099 1610 3256 An antibiotic and ribosome inhibitor. SGTC_1300 1094-0077 113 µM 0.397342652638328 0.366917626512631 no 1227 0.345557399214601 1602 5532636 SGTC_3097 9117246 49.47 µM 0.39708110157545 0.367012356171778 no 1228 0.345653827768528 1612 16423892 SGTC_2864 9034755 47.6 µM 0.396758289404578 0.367129284799784 no 1229 0.345772855854347 1623 4930451 SGTC_1749 st037932 54.2 µM 0.395506295323395 0.367582897067001 no 1230 0.346234638279702 1610 594497 SGTC_1546 5-methoxyflavanone 78.7 µM 0.39545279316783 0.367602285652695 no 1231 0.346254376983651 1712 147795 SGTC_3122 9126309 49.47 µM 0.395298415280583 0.367658232372288 no 1232 0.346311334401979 1648 17591206 SGTC_549 1661-1316 519 µM 0.394865803732903 0.367815026241621 no 1233 0.346470964097587 1742 2857282 SGTC_3072 9116419 49.47 µM 0.394630339054472 0.367900376307571 no 1234 0.346557859868216 1579 17170162 SGTC_2044 5102272 200 µM 0.39334078352647 0.368367923561049 no 1235 0.347033899915221 1624 592666 SGTC_1587 estradiol valerate 56.1 µM 0.393022516915207 0.368483345811597 no 1236 0.347151425375097 1758 13791 A steroid. SGTC_1454 4239-0054 42.6 µM 0.392866891425355 0.368539789117001 no 1237 0.347208898135908 1720 1340767 SGTC_1104 tacrolimus 29.8 µM 0.392206988480688 0.36877915868271 no 1238 0.347452640454888 1650 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_894 0960-0238 55.9 µM 0.390676665691238 0.369334455361349 no 1239 0.348018124452736 1668 6741907 YDL195W SEC31 SGTC_3188 9110789 49.47 µM 0.390401783502577 0.369434228713716 no 1240 0.348119734622085 1722 849217 SGTC_2022 5136654 200 µM 0.389813906605046 0.369647638538932 no 1241 0.348337079840396 1649 1713771 SGTC_1947 st076332 61.6 µM 0.3895159176511 0.36975582919956 no 1242 0.348447268998746 1704 24208416 SGTC_769 0302-0231 76 µM 0.388391800892336 0.370164054308815 no 1243 0.348863055442776 1690 571869 YER009W NTF2 SGTC_326 k292-0812 17.5 µM 0.387696848822085 0.370416500668994 no 1244 0.349120194014762 1752 3579357 SGTC_932 2857-0803 154 µM 0.387593685437305 0.370453980274321 no 1245 0.349158371312211 1756 674898 SGTC_750 4073-0104 132 µM 0.386838626877188 0.370728333009773 no 1246 0.34943783953138 1574 22330957 SGTC_2473 5854593 8.94 µM 0.385787823064172 0.371110255035165 no 1247 0.349826907151924 1634 2872951 SGTC_983 1491-0821 12.2 µM 0.385039378691359 0.371382359853694 no 1248 0.350104120247332 1760 46495113 SGTC_1209 2323-2347 50.3 µM 0.384633676606475 0.371529883991238 no 1249 0.350254419901171 1702 5412760 SGTC_590 k048-0076 22.4 µM 0.382845273052425 0.372180420078654 no 1250 0.350917245556645 1737 6832814 SGTC_560 2332-1943 155 µM 0.382627841704324 0.372259536173813 no 1251 0.350997861866836 1660 21177716 SGTC_1755 st041960 45.185 µM 0.380378494172896 0.373078315401581 no 1252 0.351832238100555 1664 2257073 SGTC_2811 7967822 32.47 µM 0.378478932518843 0.373770216878166 no 1253 0.352537420642458 1739 2232244 SGTC_1486 3970-0793 4.53 µM 0.377993455449848 0.373947113748779 no 1254 0.352717727867915 1745 2844330 SGTC_2911 7942208 15.64 µM 0.377384320469217 0.374169106321324 no 1255 0.35294400870996 1632 1243384 SGTC_1742 st038235 28.8875 µM 0.375721793048529 0.374775208420574 no 1256 0.353561867250047 1666 564103 YBR002C RER2 SGTC_3038 9091290 49.47 µM 0.375033469665847 0.375026238861262 no 1257 0.353817787539648 1718 25236843 SGTC_2424 5537928 59.2 µM 0.374447649862564 0.375239928124162 no 1258 0.35403564880229 1613 5382802 SGTC_905 2-aminofluorene 215 µM 0.373336049971319 0.375645511207081 no 1259 0.354449174419556 1643 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1633 st005664 67.9 µM 0.37281131545 0.375837015871033 no 1260 0.354644440263341 1624 2063822 SGTC_1452 4194-0072 190 µM 0.367101591102879 0.377922778066605 no 1261 0.35677162025026 1819 1343545 SGTC_943 3253-1379 105 µM 0.366809341199217 0.378029633335784 no 1262 0.35688061967203 1750 668464 SGTC_1230 0170-0365 3.77 µM 0.366590209716485 0.37810976045463 no 1263 0.356962356038907 1747 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1815 st051655 58.2 µM 0.36422705890829 0.378974197288553 no 1264 0.357844231306429 1778 5984156 SGTC_1695 st026914 34.495 µM 0.362620666371529 0.379562159217845 no 1265 0.358444135044054 1665 3289191 SGTC_371 0195-0006 7.36 µM 0.362091843376885 0.379755776784452 no 1266 0.358641699363839 1598 3928593 SGTC_874 0599-0792 117 µM 0.360650542591875 0.380283632097258 no 1267 0.359180350505986 1837 765305 SGTC_3347 9188721 44.724 µM 0.36061173386913 0.380297848311685 no 1268 0.359194858199446 1725 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2832 7992762 51.95 µM 0.360498032880986 0.380339499611575 no 1269 0.359237363706526 1502 2985177 SGTC_2478 5763493 32.33 µM 0.360427412206599 0.380365370295373 no 1270 0.359263765124489 1737 1365576 YLR208W SEC13 SGTC_2998 9066762 71.4286 µM 0.359540703892368 0.380690246322913 no 1271 0.359595316660359 1790 4945196 SGTC_1879 gemcitabine 100 µM 0.358711456015893 0.38099414589929 no 1272 0.359905478674814 1731 60750 A nucleoside analog which inhibits DNA replication. SGTC_1451 4152-0210 104 µM 0.358710722787449 0.380994414642549 no 1273 0.35990575296372 1792 659563 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.358612380661374 0.381030459568266 no 1274 0.359942541816787 1672 442882 SGTC_1656 st012921 11 µM 0.358538319346231 0.381057605631994 no 1275 0.359970248306153 1761 6732821 SGTC_1898 st060199 18.6 µM 0.358488172090688 0.381075986688393 no 1276 0.359989008914689 1649 688866 SGTC_1672 st016598 6.51 µM 0.358452285640393 0.381089140730827 no 1277 0.360002434615076 1645 4665860 YNL267W PIK1 SGTC_990 3985-0011 41.3 µM 0.357214854949079 0.381542800222044 no 1278 0.360465482959854 1690 5399565 YGL099W LSG1 SGTC_2697 mebhydrolin 72.4 µM 0.356910653943614 0.381654349538952 no 1279 0.360579346787857 1831 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2030 5175110 200 µM 0.356336299907288 0.381864989705825 no 1280 0.36079436383131 1750 2831986 SGTC_747 3448-8087 38.7 µM 0.352858081840666 0.383141346148234 no 1281 0.362097418893198 1657 5168703 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.350863316057312 0.383873913208568 no 1282 0.362845446785459 1666 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_405 ebelactone b 50 µM 0.348775865335699 0.384640962869961 no 1283 0.363628791842246 1685 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1371 2421-0008 32.7 µM 0.348081754787139 0.384896119321929 no 1284 0.363889393068716 1712 2827552 SGTC_2734 clemastine 41.6 µM 0.347644345520021 0.385056937475293 no 1285 0.364053649104429 1744 26987 Clemastine is a selective histamine H1 antagonist. SGTC_826 1683-5028 118 µM 0.347459600058468 0.385124867043335 no 1286 0.3641230322704 1709 722377 SGTC_1550 gossypolone 36.6 µM 0.346870213498686 0.385341603766373 no 1287 0.364344412558788 1719 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1023 4482-3888 16 µM 0.345423476686687 0.385873767961201 no 1288 0.364888015120989 1803 3303168 SGTC_548 1436-0017 110 µM 0.34512983024962 0.385981808423583 no 1289 0.364998384190657 1832 9677137 SGTC_2655 perillic acid 100 µM 0.343399676617628 0.38661855801842 no 1290 0.365648901388049 1698 5702197 An apoptosis inducer. SGTC_2504 purpurogallin 52.29 µM 0.342670302812307 0.386887081551257 no 1291 0.365923253211587 1683 5281571 An antioxidant. SGTC_1564 D-Arginine 115 µM 0.342401615428401 0.38698601414946 no 1292 0.366024336476742 1623 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2749 bexarotene 57.39 µM 0.341896783512581 0.387171916691651 no 1293 0.366214285161219 1649 82146 An retinoic acid receptor inhibitor. SGTC_803 4488-1585 147 µM 0.340751382603624 0.387593802383017 no 1294 0.366645376653734 1800 747204 SGTC_857 0438-0306 1.35 µM 0.340345625835142 0.387743286705803 no 1295 0.366798130641857 1726 4686136 SGTC_3165 9101544 49.47 µM 0.339308455231021 0.388125464956622 no 1296 0.367188686862604 1776 5002184 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.339067207999045 0.388214375663368 no 1297 0.36727955046784 1753 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2945 9067681 61.76 µM 0.339065382535946 0.388215048452864 no 1298 0.367280238040477 1747 16456930 SGTC_1759 st043059 70 µM 0.337512473026245 0.388787507402832 no 1299 0.367865305544387 1644 669426 SGTC_1288 0973-0013 65.5 µM 0.336784440547799 0.389055969916824 no 1300 0.3681397016125 1757 4315430 SGTC_3242 9133940 49.47 µM 0.336646965989939 0.389106669711657 no 1301 0.368191523448245 1766 17248444 SGTC_2570 licareol 100 µM 0.336497674947036 0.389161729494119 no 1302 0.368247802293339 1678 443158 SGTC_976 1348-1067 47.6 µM 0.335967392435047 0.389357320096089 no 1303 0.368447727874692 1713 5310671 YGL099W LSG1 SGTC_2636 apigenin dimethyl ether 100 µM 0.334891005185985 0.389754423362746 no 1304 0.368853653771642 1755 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2677 mitomycin C 100 µM 0.332338913184355 0.39069640634839 no 1305 0.369816679809524 1741 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.331198084778398 0.391117696632838 no 1306 0.370247433395124 1725 521171 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.328601695093855 0.392076978840105 no 1307 0.37122838333047 1785 676296 Flavone; oxidizing agent. SGTC_3187 9109394 49.47 µM 0.327614908536392 0.39244173707881 no 1308 0.371601424080819 1681 17098090 SGTC_1269 0831-0796 3.05 µM 0.325951234829455 0.393056915405947 no 1309 0.372230625412965 1827 927758 SGTC_2085 5307070 144.047 µM 0.325661890039655 0.393163934041164 no 1310 0.372340090485589 1698 2840351 SGTC_2964 9083345 53.42 µM 0.325408360926285 0.393257712332961 no 1311 0.37243601423199 1678 17741579 SGTC_1563 conessine 56.1 µM 0.32354428855877 0.393947406913044 no 1312 0.373141536061606 1862 441082 An anti-amoebic, histamine inhibitor. SGTC_681 1642-0006 26.6 µM 0.323063620009487 0.394125305182688 no 1313 0.373323530600508 1717 4446530 SGTC_651 3253-0966 34.4 µM 0.321625755986771 0.394657598896915 no 1314 0.373868114662603 1736 781462 SGTC_1975 st070967 30.8 µM 0.321319652655972 0.394770943026904 no 1315 0.373984082378459 1879 261391 SGTC_2492 derrusnin 100 µM 0.320329694511913 0.39513756627741 no 1316 0.374359207586398 1721 1715307 Part of coumarin class of compounds. SGTC_3217 9129673 49.47 µM 0.319409097845727 0.395478585377867 no 1317 0.374708156394511 1755 17248312 SGTC_145 3737-0113 38.366 µM 0.317560523776412 0.396163599150823 no 1318 0.375409161309933 1879 6849351 SGTC_921 1561-0023 372 µM 0.317350870673806 0.396241309193525 no 1319 0.375488690703027 1687 24050882 SGTC_2460 5552655 174.22 µM 0.316374546652287 0.396603247822976 no 1320 0.375859117173054 1708 5401989 SGTC_966 1300-0360 30.2 µM 0.315373312866907 0.396974513441761 no 1321 0.376239113491099 1731 70588 SGTC_642 0335-0876 158 µM 0.314916878153988 0.397143794152748 no 1322 0.37641238311771 1753 6812350 SGTC_1404 3909-7820 48.3 µM 0.313935416795111 0.39750786027889 no 1323 0.376785045240836 1851 23741373 SGTC_1781 st038725 66.3 µM 0.313289165023833 0.397747631565872 no 1324 0.377030490582919 1720 4270275 YIL048W NEO1 SGTC_1279 0874-0590 65.2 µM 0.312707798994996 0.397963362060497 no 1325 0.377251334895589 1794 3523074 SGTC_2166 5933061 31.504 µM 0.312677255046515 0.397974697024424 no 1326 0.37726293877807 1858 2877375 SGTC_2178 5812956 200 µM 0.312461790078449 0.398054659258095 no 1327 0.377344798735169 1762 5403383 SGTC_2653 dihydrofissinolide 100 µM 0.312212818168522 0.398147061745473 no 1328 0.377439395591776 1795 6857746 SGTC_1763 st044482 94.5 µM 0.311249417864884 0.398504668242699 no 1329 0.377805508689661 1829 88505 SGTC_902 1120-0002 2.07 µM 0.310903271855423 0.3986331757081 no 1330 0.377937078540388 1726 3280475 SGTC_228 caffeine 993.056 µM 0.310134307411428 0.39891869475611 no 1331 0.378229412023756 1850 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2993 9054257 71.4286 µM 0.309494322862664 0.399156364395364 no 1332 0.378472765015436 1742 6470217 YGL055W OLE1 SGTC_2803 7707263 71.43 µM 0.308945088120564 0.399360362295038 no 1333 0.378681648994485 1723 2199229 SGTC_2371 9071574 200 µM 0.308720949586118 0.399443620190714 no 1334 0.378766903150525 1856 45596039 SGTC_101 0490-5701 117.494 µM 0.307580711896932 0.399867240543856 no 1335 0.379200699407312 1864 4661669 SGTC_3033 9090887 49.47 µM 0.306967563618876 0.400095085755396 no 1336 0.379434030758304 1723 19325384 SGTC_1201 1889-3372 45.9 µM 0.306581856139365 0.400238431653965 no 1337 0.379580832848862 1769 5392199 SGTC_25 0118-0223 35.662 µM 0.305766457947858 0.400541513777955 no 1338 0.379891234375606 1845 5333628 SGTC_2221 6807166 181.081 µM 0.305150125434533 0.400770643282686 no 1339 0.380125907991613 1828 674925 SGTC_1291 0993-0025 5.79 µM 0.305126920812502 0.400779270565523 no 1340 0.380134744202852 1856 4353356 SGTC_186 3455-3465 67.277 µM 0.304181870938081 0.401130673217322 no 1341 0.380494667874525 1781 755278 SGTC_1658 st012944 20 µM 0.302609764949401 0.401715414398409 no 1342 0.381093635923248 1846 24207260 SGTC_2299 7976368 114.88 µM 0.301083263610763 0.402283403689591 no 1343 0.381675501473986 1881 2979718 SGTC_2009 4012297 12.05 µM 0.300937685855894 0.402337581885958 no 1344 0.381731006199117 1745 45595307 SGTC_3291 9121177 71.43 µM 0.299717877370368 0.402791619260918 no 1345 0.382196180496536 1753 17015612 SGTC_1429 4049-0205 9.46 µM 0.299631808800652 0.402823660681952 no 1346 0.382229009200763 1810 22774478 SGTC_1016 4226-1401 38 µM 0.299408304368139 0.40290686947629 no 1347 0.38231426333231 1761 2901613 SGTC_2881 9058953 51.95 µM 0.298502078428837 0.403244294690942 no 1348 0.382659995014248 1755 17122249 SGTC_1339 1486-1321 22.7 µM 0.295571988544648 0.404335779639438 no 1349 0.383778484096408 1770 3469382 SGTC_3241 9133421 49.47 µM 0.294995186556875 0.404550731623895 no 1350 0.383998778376166 1808 17018221 SGTC_795 0685-0265 78 µM 0.294660412826728 0.404675502174896 no 1351 0.384126653554391 1765 302754 SGTC_185 k048-0037 25.491 µM 0.294422634365541 0.404764128366795 no 1352 0.384217486632435 1917 6827589 SGTC_158 k038-0087 26.446 µM 0.293402205482693 0.405144524064704 no 1353 0.384607369932268 1805 X158 SGTC_2140 5586273 200 µM 0.293204475925672 0.405218244109395 no 1354 0.384682931535763 1795 854421 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.292589653273429 0.405447491574291 no 1355 0.384917911667097 1840 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_120 rhodamine 6G 52.259 µM 0.291995483521217 0.405669069066037 no 1356 0.385145038600058 1755 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1850 st056238 17 µM 0.290433500548103 0.406251706999705 no 1357 0.3857423089529 1793 5393177 SGTC_454 lyso-paf C-16 6.67 µM 0.290009793367763 0.40640979059666 no 1358 0.385904372700577 1699 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2011 4012611 177 µM 0.289733775994258 0.406512779875499 no 1359 0.386009957292344 1739 2049887 SGTC_276 colchicine 750 µM 0.287553071859824 0.407326684284766 no 1360 0.386844435704147 1830 2833 A microtubule depolymerizer. SGTC_1720 st037298 9.481 µM 0.285995996738598 0.407908076734286 no 1361 0.387440593848897 1773 597396 SGTC_2836 9010338 19.48 µM 0.285693566195845 0.408021024095838 no 1362 0.387556416422715 1656 2994051 SGTC_1843 st055809 45.5 µM 0.285598308473554 0.408056601148222 no 1363 0.387592899581477 1808 16413835 SGTC_2730 imipramine 71.33 µM 0.28550469705632 0.408091564073671 no 1364 0.387628753181862 1901 3696 A tricyclic antidepressant. SGTC_1388 3346-4487 254 µM 0.283915154662837 0.408685353708844 no 1365 0.38823770122563 1859 3345614 SGTC_1987 st072290 61.9 µM 0.282561384902815 0.409191233481599 no 1366 0.388756542409659 1805 54697379 SGTC_3157 9099274 49.47 µM 0.282392065709568 0.409254515724541 no 1367 0.38882144909099 1941 17217662 SGTC_2139 5578692 56.4705 µM 0.282363043427526 0.409265362901846 no 1368 0.38883257478052 1928 650991 YMR113W FOL3 SGTC_3213 9129884 49.47 µM 0.280710988901066 0.409882938227018 no 1369 0.389466039797374 1699 17190742 SGTC_2645 abamectin 100 µM 0.280678136212494 0.409895221577337 no 1370 0.38947863984172 1893 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3240 9133527 49.47 µM 0.280305598048178 0.410034516719748 no 1371 0.389621528127241 1819 17617455 SGTC_2071 5230951 39.92 µM 0.280181479465372 0.410080928220564 no 1372 0.389669137548501 1907 1799272 SGTC_230 MPP+ 141.667 µM 0.279625443794892 0.410288861370804 no 1373 0.389882442092535 1751 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2187 6125751 200 µM 0.279217173746243 0.410441552669819 no 1374 0.390039082403796 1838 874498 SGTC_2203 7227154 166.4 µM 0.278128931671305 0.410848616938959 no 1375 0.390456693657256 1829 896304 SGTC_1708 st033234 31.827 µM 0.276706760462752 0.411380734340434 no 1376 0.391002640198581 1912 674664 SGTC_942 3253-1115 227 µM 0.275871640442511 0.411693277621933 no 1377 0.391323328308352 1913 46497897 SGTC_93 0109-0045 59.227 µM 0.275498321838248 0.411833010072628 no 1378 0.391466707466795 1944 88733 SGTC_1674 st016616 23.6 µM 0.273359657383213 0.412633723132352 no 1379 0.392288380447462 1710 625830 SGTC_1690 st023502 41.2 µM 0.272926584782391 0.412795909312808 no 1380 0.392454825170503 1921 24207482 SGTC_707 0865-0008 204 µM 0.271909553139017 0.413176847304848 no 1381 0.39284578277853 1880 723043 SGTC_1881 5652484 16 µM 0.271088561828646 0.413484416351186 no 1382 0.393161459323303 1935 2255129 SGTC_2228 7354201 200 µM 0.265180386140104 0.415699358690181 no 1383 0.39543525188746 1916 753451 SGTC_1133 3473-0247 50 µM 0.264775338392517 0.415851307843608 no 1384 0.395591268077181 1726 711311 SGTC_951 1171-0579 82.7 µM 0.264130472782711 0.41609324794948 no 1385 0.395839691768016 1789 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_395 anisomycin 6.25 µM 0.263554325567991 0.416309433250009 no 1386 0.396061678642743 1822 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_586 0957-0265 8.15 µM 0.262014366757655 0.416887389644254 no 1387 0.396655182977077 1961 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_390 dec-rvkr-cmk 16.7 µM 0.26081135474577 0.417339012824351 no 1388 0.397118993804511 1884 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2947 9072639 7.68 µM 0.26018989128227 0.417572359416466 no 1389 0.397358650697065 1793 16488146 SGTC_2516 gossypol 71.55 µM 0.258991076901242 0.418022571198558 no 1390 0.397821062634275 1947 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2511 berberine 10.47 µM 0.258753251332407 0.418111898794677 no 1391 0.397912814843632 1813 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_473 2-arachidonoylglycerol 10 µM 0.258400215582529 0.418244507274413 no 1392 0.398049025117713 1791 5282280 An endocannabinoid. SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.258101426375735 0.418356746746591 no 1393 0.398164315389519 1929 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.258071820977364 0.418367868307938 no 1394 0.398175739360166 1902 5393153 SGTC_1241 0364-0022 50.8 µM 0.2578437310262 0.418453554746551 no 1395 0.398263756400111 1876 4563895 SGTC_10 0279-0212 42.575 µM 0.255832835512231 0.419209153870459 no 1396 0.399039959170982 1854 39851 YBR002C RER2 SGTC_379 3970-0972 5.9 µM 0.255498057798512 0.419334976467221 no 1397 0.399169221748805 1877 2898042 YBL034C STU1 SGTC_2792 7535235 81.82 µM 0.253216895484454 0.420192545706277 no 1398 0.400050305583489 1779 1281891 SGTC_1555 citronellol 128 µM 0.25239911574154 0.420500070413016 no 1399 0.400366291781124 1994 8842 A terpine precursor. SGTC_1553 gossypol 38.6 µM 0.252379597288738 0.420507410888309 no 1400 0.400373834416111 1908 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_762 1165-0429 115 µM 0.250350593405652 0.421270626463501 no 1401 0.401158116968702 1978 5967793 SGTC_2389 9091542 195.52 µM 0.250272370043721 0.42130005634571 no 1402 0.401188361092061 1840 3626624 YOL127W RPL25 SGTC_2942 9052777 62.25 µM 0.250043770948442 0.421386064430252 no 1403 0.401276749579479 1862 6469503 SGTC_1303 1160-0052 261 µM 0.249245513369018 0.421686430118907 no 1404 0.401585437729735 1956 3562476 SGTC_2534 helenine 20.12 µM 0.249129904518691 0.421729934811739 no 1405 0.401630149050136 1838 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_885 0865-0106 16.8 µM 0.249093001779522 0.421743821859172 no 1406 0.401644421327206 1799 2793380 SGTC_3225 9130819 49.47 µM 0.248981316003915 0.421785851463971 no 1407 0.401687617032094 1944 4547121 SGTC_456 gingerol 170 µM 0.247584211724866 0.422311685047418 no 1408 0.402228063843805 1896 442793 A herb. SGTC_1603 st002045 67.8 µM 0.245130428515867 0.423235559691823 no 1409 0.403177721488875 1987 5887985 SGTC_1170 0310-0127 64.8 µM 0.243341920270972 0.423909217817596 no 1410 0.403870266238008 1904 774975 SGTC_1825 st052143 62.6 µM 0.241417815987263 0.424634197750671 no 1411 0.404615652944355 1964 674173 SGTC_1396 3511-0007 98.6 µM 0.241195159528357 0.424718108603448 no 1412 0.404701931156082 1879 X1396 SGTC_2147 5545932 89.7195 µM 0.240579984809705 0.424949962561641 no 1413 0.404940332211807 1887 797404 SGTC_83 0170-0301 39.027 µM 0.239498624482429 0.425357580673634 no 1414 0.405359481468125 1964 3089716 SGTC_3061 glucosamine 200 µM 0.236230771639794 0.42658987901869 no 1415 0.406626801406473 2012 91431 and experimental redox chemotherapeutic SGTC_1922 5578187 25 µM 0.236119435628745 0.426631876220429 no 1416 0.406669996412264 1988 1350412 SGTC_794 k038-0031 316 µM 0.235033733694571 0.427041458796591 no 1417 0.407091275385089 1850 6624242 SGTC_2768 sulfasalazine 50.2 µM 0.234483560316114 0.42724904253538 no 1418 0.407304797221523 2003 5384001 An antioxidant and salicylic acid derivative. SGTC_1264 0783-0040 158 µM 0.233748128374316 0.427526556902207 no 1419 0.407590260766821 1813 2855798 SGTC_2428 5615643 7.78 µM 0.233491105100037 0.427623552792214 no 1420 0.407690037901309 1934 2253075 SGTC_3085 9117376 49.47 µM 0.232770801510485 0.427895405503013 no 1421 0.407969693600546 1909 16480349 SGTC_420 mitomycin C 81.9 mM 0.231000182497618 0.42856380726823 no 1422 0.408657330125586 1881 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3015 9080845 49.47 µM 0.228165983439068 0.429634132193371 no 1423 0.409758602628443 1991 5296973 SGTC_3055 9094636 49.47 µM 0.228101439149412 0.429658513164299 no 1424 0.409783690652951 1948 25236176 SGTC_1089 terbinafine 2.25 µM 0.227591155132103 0.429851277373028 no 1425 0.409982048350941 2008 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.227243189613727 0.429982733955342 no 1426 0.410117322785909 1909 4213774 SGTC_1786 berberine 21.6 µM 0.225736931897808 0.430551866725017 no 1427 0.410703015939134 1854 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1500 4488-1866 171 µM 0.225293367194396 0.430719493226415 no 1428 0.410875529630142 2006 2900003 SGTC_1114 scopoletin 1.73284 µM 0.223086634627 0.431553619330416 no 1429 0.411734040137985 2023 5280460 A coumarin with genotoxic properties. SGTC_1681 tripelennamine 100 µM 0.221242714769807 0.43225083962496 no 1430 0.412451725818664 2008 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_743 1275-0778 158 µM 0.220862587704653 0.432394599026659 no 1431 0.412599714368171 2011 2849257 YMR203W TOM40 SGTC_1394 3474-0001 65.7 µM 0.217196809907544 0.433781407896968 no 1432 0.414027485336936 1908 5017666 YIL048W NEO1 SGTC_944 3370-0224 231 µM 0.216952710289407 0.433873782937266 no 1433 0.414122599430104 1865 4580514 SGTC_52 0329-0193 875 nM 0.216554535967236 0.434024472482392 no 1434 0.414277759966362 1994 3739292 SGTC_350 k064-0020 19.8 µM 0.216130437578094 0.434184983566033 no 1435 0.414443037304824 2048 2790705 SGTC_2315 7733312 200 µM 0.215867835748362 0.434284377511186 no 1436 0.414545384671191 1894 726316 SGTC_1642 st009582 77.7 µM 0.214483474442018 0.434808422331362 no 1437 0.415085026301123 2047 6739311 SGTC_335 4077-0256 27.6 µM 0.214380262977182 0.434847497246991 no 1438 0.41512526587328 1999 3121989 SGTC_1981 st071826 47 µM 0.214142066496725 0.434937678682036 no 1439 0.415218136129288 1923 11838600 SGTC_2351 9026858 72.31 µM 0.213628804051282 0.435132011875826 no 1440 0.415418267753376 1883 1409300 SGTC_3263 9137018 49.47 µM 0.212651130111602 0.435502225461037 no 1441 0.415799543678308 1834 43844957 SGTC_133 0724-0033 378.92 µM 0.211940869139413 0.435771213854718 no 1442 0.416076582908099 2032 280309 SGTC_2689 tacrolimus 100 µM 0.210830153702404 0.436191920962351 no 1443 0.416509904052031 1902 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_834 0312-0008 75.7 µM 0.210684547550995 0.436247077753781 no 1444 0.416566716617203 1923 6385573 YIL048W NEO1 SGTC_2776 terbinafine 19.92 µM 0.210639094671378 0.436264295927291 no 1445 0.416584451765355 2020 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_47 0149-0135 24.25 µM 0.210566738428644 0.436291705712485 no 1446 0.416612684621377 1807 5239155 SGTC_937 3122-0005 46.7 µM 0.208872199464946 0.436933713327459 no 1447 0.417274003544683 2054 759535 SGTC_1155 4088-0394 48.2 µM 0.208463875186194 0.43708843948035 no 1448 0.417433393212467 1879 2326248 SGTC_43 0570-0105 72.5 µM 0.205299500032823 0.438287839356523 no 1449 0.418669067327517 1947 1114046 YDL195W SEC31 SGTC_2128 5255449 168.493 µM 0.204720716286147 0.438507278666308 no 1450 0.418895166969197 1949 736008 SGTC_68 0986-0284 82.829 µM 0.204652818339392 0.438533022645013 no 1451 0.418921692797867 1754 423278 YIL048W NEO1 SGTC_1660 st012960 28.1 µM 0.204549335569399 0.438572259357138 no 1452 0.418962121330596 1946 24207266 SGTC_295 k015-0027 31 µM 0.202667534595652 0.439285871313528 no 1453 0.419697450089308 1985 3887424 SGTC_1342 1486-1464 234 µM 0.202048496178663 0.43952066479908 no 1454 0.419939405728936 1918 3253938 SGTC_1306 1185-0270 9.02 µM 0.201893927968295 0.439579293899879 no 1455 0.419999824556473 2039 1548076 SGTC_1091 telmisartan 47.6 µM 0.201175854945215 0.43985168276095 no 1456 0.420280535244023 2023 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_296 1222-0039 74.9 µM 0.201025949099818 0.439908550605885 no 1457 0.420339141888619 1922 5984176 SGTC_171 k064-0041 9.68 µM 0.200226765966249 0.440211747287492 no 1458 0.420651617398134 1894 53325 SGTC_1649 st011737 51.3 µM 0.200002053640259 0.440297005699407 no 1459 0.420739487500043 1938 1761035 SGTC_1360 1598-0022 39.8 µM 0.199940926701675 0.44032019843413 no 1460 0.420763390879063 2012 761525 SGTC_2067 5224629 34.075 µM 0.199509667056172 0.440483832441688 no 1461 0.420932041070518 1890 2835000 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.198743073263438 0.440774728261572 no 1462 0.421231864233284 2032 91467 include heat shock SGTC_1297 1068-0111 14.1 µM 0.196703838696649 0.44154870240233 no 1463 0.422029652970323 1905 767057 SGTC_1640 st009078 66.4 µM 0.196685150193631 0.441555796501601 no 1464 0.422036965765864 2044 690618 SGTC_2448 5185112 27.17 µM 0.194787297322772 0.442276312952917 no 1465 0.422779733541315 1938 5718189 SGTC_2345 9052315 157.45 µM 0.193195923736071 0.442880622415423 no 1466 0.4234027654941 1935 6469265 SGTC_1689 st020265 53.493 µM 0.192382483619882 0.443189570226366 no 1467 0.423721306085723 2075 5758320 YPR016C TIF6 SGTC_2467 5474540 200 µM 0.191896979234494 0.443373983206781 no 1468 0.423911451846411 2038 5413519 SGTC_897 1000-0139 31.4 µM 0.191770362416898 0.443422079094655 no 1469 0.423961043707475 2082 6151020 SGTC_1461 k072-0203 53.8 µM 0.190852786247632 0.443770648814901 no 1470 0.424320465629448 2078 5418714 SGTC_410 α-linolenic acid 100 µM 0.190460879032241 0.443919540181094 no 1471 0.424473998020755 2038 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.18941821413773 0.444315702535745 no 1472 0.424882525026158 2138 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2152 5568786 200 µM 0.188822752758582 0.444541974117649 no 1473 0.425115869247018 2010 5399883 SGTC_2365 9042475 200 µM 0.187024921533659 0.445225248054394 no 1474 0.425820546566371 1951 6464479 SGTC_1439 4092-1168 46 µM 0.186790467471984 0.445314365426699 no 1475 0.425912460615439 2045 2886240 SGTC_675 1309-0189 238 µM 0.185052810672322 0.44597494487534 no 1476 0.426593806943638 1960 4246530 SGTC_2630 antimycin a 100 µM 0.184182054396701 0.446306024018225 no 1477 0.426935318580598 1995 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1190 1486-1332 13 µM 0.184058709481885 0.446352925281243 no 1478 0.426983699036337 2058 4150046 SGTC_2622 2-methoxyxanthone 59.94 µM 0.184057725992699 0.446353299250913 no 1479 0.42698408480173 2058 71034 A hepatoprotective. SGTC_785 1270-0111 65.3 µM 0.183569187837542 0.446539070736881 no 1480 0.42717571842538 2126 6741994 SGTC_1609 st001574 46.4 µM 0.183262916819804 0.44665553931975 no 1481 0.427295864840826 1937 3960012 SGTC_1505 k297-0037 20.6 µM 0.180556379432054 0.44768497882946 no 1482 0.428357898602375 1940 4089396 SGTC_2957 9076800 11.52 µM 0.180361627307386 0.447759067053534 no 1483 0.428434338618761 1942 16459615 SGTC_3282 9108498 15.4605 µM 0.179559706548259 0.448064155480557 no 1484 0.428749119983911 1956 16459645 SGTC_1845 st056753 3.01 µM 0.179501136142853 0.448086439627532 no 1485 0.428772112652827 1908 5375839 SGTC_2860 9025725 38.96 µM 0.179241153499815 0.448185356600309 no 1486 0.428874175557076 1885 40546248 SGTC_2580 diallyl disulphide 81.36 µM 0.179169136099137 0.448212758012171 no 1487 0.428902448690097 1962 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2544 sphondin 68.51 µM 0.177450113747656 0.448866890203604 no 1488 0.429577423380398 2059 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3346 9158254 43.5805 µM 0.176782026070533 0.449121152348916 no 1489 0.429839803900204 2006 17639500 SGTC_994 3910-0338 138 µM 0.176513652716316 0.449223296305775 no 1490 0.429945211881603 2048 3479481 SGTC_3094 9117742 49.47 µM 0.175557683973224 0.449587169074864 no 1491 0.430320724610306 2103 17149698 SGTC_900 1112-0045 141 µM 0.175132238459984 0.449749121112892 no 1492 0.430487863546216 2103 56211 YIL048W NEO1 SGTC_2981 9013952 38.96 µM 0.174769518449306 0.449887202384887 no 1493 0.43063037021153 1865 2996344 SGTC_291 SEC14.278 35.5 µM 0.174581705025427 0.449958702111634 no 1494 0.43070416253621 2087 1068044 SGTC_2446 5162541 200 µM 0.173236837526572 0.450470734451831 no 1495 0.431232634602767 1963 1549321 SGTC_2184 6075246 200 µM 0.172993496420113 0.450563390714477 no 1496 0.431328269828595 2021 2267320 SGTC_18 0111-0177 500 nM 0.172218576838167 0.45085847244531 no 1497 0.431632846935371 2023 721752 SGTC_1077 5-fluorocytosine 377 nM 0.169950171786314 0.451722414243314 no 1498 0.432524661809026 2022 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1613 st002381 52.1 µM 0.169798436049016 0.451780212324556 no 1499 0.432584328460567 2141 551167 SGTC_679 0422-0091 41.4 µM 0.168718891969616 0.452191453891598 no 1500 0.433008879084569 1968 627384 YHR062C RPP1 SGTC_1504 k297-0033 30 µM 0.168575442012762 0.452246103594929 no 1501 0.433065299257699 1936 4388117 SGTC_1005 4092-0690 4.4 µM 0.168271922539839 0.452361737486811 no 1502 0.433184680723883 1972 1529343 SGTC_2235 salicylic acid 500 µM 0.167767654929916 0.452553860699825 no 1503 0.433383034707597 2116 338 A COX inhibitor and kinase inhibitor. SGTC_1476 4112-3294 3.34 µM 0.1674377069908 0.452679575082869 no 1504 0.43351282902385 2084 704369 SGTC_3233 9132340 49.47 µM 0.167184352819278 0.452776109481537 no 1505 0.433612497891813 1974 17682950 SGTC_989 1501-0895 10.3 µM 0.166260514749021 0.453128138943123 no 1506 0.433975969088462 2125 2830112 SGTC_149 3970-0822 46.1 µM 0.166049721156201 0.453208467233506 no 1507 0.434058910719923 2031 3114250 YBL034C STU1 SGTC_2713 st079149 53.4 µM 0.164224834954662 0.453903966489262 no 1508 0.434777075527892 2024 3103253 SGTC_2507 purpurin 79.67 µM 0.164164793629464 0.453926851807945 no 1509 0.434800707831584 1912 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2719 novobiocin 32.65 µM 0.163428597449669 0.454207472355674 no 1510 0.435090494028171 2104 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_906 1165-0455 526 µM 0.162570928361656 0.454534424318709 no 1511 0.435428139120928 2011 3252859 SGTC_526 4469-0568 170 µM 0.162505313027886 0.454559438806106 no 1512 0.435453972348699 1921 2901964 SGTC_303 1348-1668 34.2 µM 0.161622389555226 0.45489605258638 no 1513 0.435801612403302 2044 5380509 SGTC_1512 0259-0544 12.2 µM 0.160999787430538 0.455133438574164 no 1514 0.436046784031374 2006 18476 SGTC_1483 3453-0561 55.9 µM 0.160610747104609 0.455281780164711 no 1515 0.436199994915124 2085 4546991 SGTC_347 4534-1311 26.2 µM 0.160124997548359 0.45546700586325 no 1516 0.436391305021436 2086 2862016 SGTC_1034 k072-0165 12.7 µM 0.158930032765035 0.455922710159534 no 1517 0.436861999344955 2122 5835461 SGTC_172 1112-0046 2.638 µM 0.158844077795984 0.455955491651767 no 1518 0.436895860295928 2016 2802135 YIL048W NEO1 SGTC_931 2812-0076 566 µM 0.158667743535947 0.456022742921647 no 1519 0.436965326554362 1961 3450959 SGTC_2759 disulfiram 3.38 µM 0.156668954228904 0.45678513912378 no 1520 0.437752877908452 2037 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3089 9117425 49.47 µM 0.155242737186183 0.457329237088935 no 1521 0.438314978636065 1964 9401657 SGTC_3305 9127027 53.8275 µM 0.15474600780628 0.457518756844616 no 1522 0.438510778923788 2030 41905295 SGTC_640 3381-0960 37.1 µM 0.154167218779175 0.457739597429565 no 1523 0.438738944383681 2116 1745025 SGTC_1727 st034309 9.9045 µM 0.152234114190717 0.458477279799944 no 1524 0.439501144146448 2154 870305 SGTC_1769 st044406 64.4 µM 0.151433483696362 0.458782846428952 no 1525 0.439816888925069 1985 670903 SGTC_773 4358-1457 44.6 µM 0.150646781805964 0.459083120826944 no 1526 0.440127177969678 2164 1186886 SGTC_565 1418-0001 44.5 µM 0.150643154500386 0.459084505378896 no 1527 0.440128608728032 2120 2862145 SGTC_1236 0330-0013 258 µM 0.150029127218629 0.459318888325082 no 1528 0.440370817569144 2008 4617066 SGTC_1007 4101-0031 70 µM 0.149595491287665 0.459484421851385 no 1529 0.440541882792761 2150 1146276 SGTC_3034 9090421 49.47 µM 0.149345256416478 0.459579948177596 no 1530 0.440640603105637 2144 17173761 SGTC_1897 st060201 15 µM 0.149284704604306 0.459603063980492 no 1531 0.440664491992907 1962 611878 SGTC_2438 5259590 200 µM 0.148616077048839 0.459858323252886 no 1532 0.440928293123465 2130 1201127 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.148377899745908 0.459949255253232 no 1533 0.441022270225133 1986 2374 Ca(2+)-ATPase inhibitor. SGTC_12 0849-0099 9.267 µM 0.148350773162921 0.459959611849323 no 1534 0.441032973712898 2139 6071388 SGTC_2285 7945142 200 µM 0.147886964518826 0.460136692488422 no 1535 0.441215987944946 2035 2970608 SGTC_116 0155-0182 31.788 µM 0.14673636906391 0.460576020172909 no 1536 0.441670055471317 1998 771486 SGTC_2251 lansoprazole 556 µM 0.145845554977581 0.460916189563758 no 1537 0.442021656348286 1945 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1899 st063254 59.6 µM 0.144049740034896 0.461602032447876 no 1538 0.442730596159162 1976 3093813 SGTC_2930 9013230 14.89 µM 0.143706559322078 0.461733110265612 no 1539 0.442866095688794 2121 2995857 SGTC_1247 0448-0043 5.84 µM 0.143232755507929 0.461914086383806 no 1540 0.443053180683016 2030 3089013 YGL099W LSG1 SGTC_2408 sulbentine 18.36 µM 0.143224932116213 0.461917074706033 no 1541 0.443056269914656 2042 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1035 k081-0041 55.2 µM 0.142781555192692 0.462086436104632 no 1542 0.443231352319229 2177 731709 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.142741057674961 0.462101905715247 no 1543 0.443247344689542 2056 15053 SGTC_329 k048-0121 21.3 µM 0.142387610844158 0.46223692098541 no 1544 0.443386923896663 2052 6832902 SGTC_580 1123-0028 41 µM 0.142020863005468 0.46237702178708 no 1545 0.443531763212697 2150 1677248 YPR107C YTH1 SGTC_1667 st014849 34.6 µM 0.141205626030762 0.462688465957992 no 1546 0.443853750840435 2148 5348460 SGTC_1731 st035964 63 µM 0.138696008622344 0.463647355370042 no 1547 0.444845186136759 1972 6739575 SGTC_3349 9149703 23.001 µM 0.137239126133093 0.46420410687944 no 1548 0.445420892650231 2162 4910494 SGTC_2962 9082311 13.18 µM 0.136861101443038 0.464348581516329 no 1549 0.445570292998707 2063 16459453 SGTC_1620 st003704 16.5 µM 0.136660292423251 0.464425329237146 no 1550 0.445649658519508 2157 2834414 SGTC_2276 7947513 42.08 µM 0.136537481612203 0.464472267272462 no 1551 0.445698197970407 1903 2105100 SGTC_2807 7945238 51.95 µM 0.136187210771585 0.464606142769564 no 1552 0.445836642647523 2088 17148797 SGTC_805 3852-0218 479 µM 0.135903604544243 0.464714541610544 no 1553 0.445948742951264 1983 6615355 SGTC_3059 1327-0034 3 µM 0.134671599055709 0.465185464128656 no 1554 0.446435764629622 2051 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1233 0325-0408 14.2 µM 0.134135045157739 0.465390572094641 no 1555 0.446647894004573 2136 12874 SGTC_2303 7774051 200 µM 0.132857780117083 0.465878867925282 no 1556 0.447152928703616 2148 2953184 SGTC_1534 6-azauridine 81.6 µM 0.132188060198445 0.466134921066795 no 1557 0.447417772413864 2150 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_207 4185-0010 4.486 µM 0.132007320191841 0.466204025563927 no 1558 0.447489250873222 2169 3761753 SGTC_311 1315-0136 58 µM 0.131706803242167 0.466318928072582 no 1559 0.447608102095508 2144 6759207 SGTC_1324 1418-0026 34.4 µM 0.131202313383177 0.466511825830758 no 1560 0.44780763298211 2088 1372513 SGTC_1600 coumarin 106 71.1 µM 0.129257801586407 0.467255406470537 no 1561 0.448576830354976 2125 100336 A hepatotoxic, DNA x-linker. SGTC_3026 9090633 49.47 µM 0.128663461590623 0.467482704803453 no 1562 0.448811974231931 2104 25236842 SGTC_2053 5265679 138 µM 0.128445702020621 0.467565987044865 no 1563 0.448898132840976 2122 764595 SGTC_591 4299-0174 154 µM 0.126081206766868 0.46847037990956 no 1564 0.449833821787346 2119 5509088 SGTC_1652 st011932 78 µM 0.126076094882728 0.468472335325777 no 1565 0.449835844989754 2170 1551076 SGTC_627 1391-0720 175 µM 0.12481755086613 0.468953781116094 no 1566 0.450333996236161 2093 997839 SGTC_64 000l-0018 272.079 µM 0.12448012052526 0.469082870099459 no 1567 0.450467569736089 1996 6811119 SGTC_2928 9011484 9.79 µM 0.124462080863351 0.469089771531423 no 1568 0.450474710985243 2084 2994751 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.122803214645502 0.469724443270503 no 1569 0.451131464305931 2093 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_53 0973-0023 39.979 µM 0.122660393874806 0.46977908921509 no 1570 0.451188014034937 2227 674768 SGTC_2601 securinine 100 µM 0.122309164753573 0.469913478579394 no 1571 0.451327087035434 2088 442872 A GABA receptor antagonist. SGTC_144 4161-2749 112.381 µM 0.121442972419444 0.470244920831258 no 1572 0.451670090835733 2111 797501 YMR168C CEP3 SGTC_639 0833-0042 114 µM 0.120673708303786 0.47053929149063 no 1573 0.451974742258101 2067 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1824 st053723 68.6 µM 0.120456873636689 0.47062226950228 no 1574 0.452060620339351 2051 675225 SGTC_1684 st024538 14.6195 µM 0.119868436578453 0.470847458256663 no 1575 0.452293684058482 2072 6732859 SGTC_77 0828-0286 12.516 µM 0.119848210928949 0.470855198568919 no 1576 0.452301695174138 2201 745345 SGTC_972 1319-0219 195 µM 0.114361331096287 0.472955412547602 no 1577 0.454475683075117 2082 23903702 SGTC_1833 st055984 71 µM 0.111935638562473 0.473884138511702 no 1578 0.455437219337317 2080 676288 SGTC_2206 7254556 146.969 µM 0.110814866663985 0.474313297193892 no 1579 0.455881578034867 2201 4398905 SGTC_170 4197-0004 226 µM 0.109861030948389 0.474678557258823 no 1580 0.456259794105832 2145 218692 SGTC_249 wiskostatin 11.211 µM 0.109331429092021 0.474881371212596 no 1581 0.456469809597591 2202 2775510 A n-wasp and actin depolymerizer. SGTC_674 0498-0004 451 µM 0.108644560498744 0.475144421019235 no 1582 0.456742207875853 2065 4231473 SGTC_2436 5633522 8.09 µM 0.10655157118083 0.475946038678295 no 1583 0.457572370183629 2226 5724242 SGTC_3047 9092122 49.47 µM 0.106458261286438 0.47598177878162 no 1584 0.457609384914656 2102 17173831 SGTC_1916 st067606 49.2 µM 0.106415288521544 0.475998238527214 no 1585 0.457626431733593 2182 19590279 SGTC_545 4218-0007 221 µM 0.106226184370754 0.476070671081134 no 1586 0.457701448177491 2143 2840508 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.106225849855458 0.476070799211213 no 1587 0.457701580878971 2211 2346 DNA damaging agent; causes G2/M arrest. SGTC_3170 9103054 49.47 µM 0.105684714121252 0.476278074770483 no 1588 0.457916254393356 2124 16432970 SGTC_2054 5233173 129 µM 0.105490394723948 0.476352508056633 no 1589 0.4579933456817 2145 6889 SGTC_1156 4092-0367 4.88 µM 0.105009567068977 0.476536690753236 no 1590 0.458184108635608 2083 1357585 SGTC_2788 5282734 71.43 µM 0.104931788535082 0.476566484561759 no 1591 0.458214967298695 2192 743706 SGTC_2821 7996764 71.43 µM 0.104520804514081 0.476723918078062 no 1592 0.458378029543297 2152 2987135 SGTC_1057 3448-5381 134 µM 0.103295915878842 0.477193151265522 no 1593 0.458864058469047 2200 5497911 SGTC_3032 9089427 49.47 µM 0.103295210786439 0.477193421383129 no 1594 0.45886433826353 2135 17173707 SGTC_924 2046-0044 21.3 µM 0.102419711393364 0.477528829156769 no 1595 0.459211769256894 2238 3623589 SGTC_1467 k284-1082 293 µM 0.102145183295906 0.477634005400872 no 1596 0.459320718730358 2248 3334705 SGTC_1960 st011366 51.8 µM 0.100802024326636 0.478148614084971 no 1597 0.45985380992401 2221 3972846 SGTC_138 0850-0259 40.9225 µM 0.100550799706365 0.478244870627533 no 1598 0.459953527408704 2239 6813004 SGTC_1367 1812-0510 76.9 µM 0.0991961678730175 0.4787639186224 no 1599 0.460491258723967 2186 1142582 YDR527W RBA50 SGTC_99 0109-0120 622.8 µM 0.0988201820511088 0.478907989788818 no 1600 0.460640521983078 2216 759414 SGTC_102 gallobenzophenone 83.616 µM 0.0986480099104505 0.478973964051675 no 1601 0.460708874750329 2231 70837 SGTC_1374 2889-5571 141 µM 0.0975497387664485 0.479394821631259 no 1602 0.461144918358709 2136 2853281 SGTC_218 alverine citrate 93.75 µM 0.0964884021066281 0.47980154774631 no 1603 0.461566342362953 2215 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2611 pyromycin 23.93 µM 0.0953345004430695 0.480243770530215 no 1604 0.46202457002461 2141 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3254 9136651 49.47 µM 0.0952429122975505 0.480278871939756 no 1605 0.462060942901091 2251 16454030 SGTC_767 0929-0023 86 µM 0.0951966405614496 0.480296605768483 no 1606 0.462079319156918 2246 1204563 SGTC_1205 4161-2785 76 µM 0.0936165665637029 0.480902198645174 no 1607 0.462706874597883 2053 3498106 SGTC_1273 0849-0096 14.1 µM 0.0931256971043933 0.481090342574244 no 1608 0.462901851401987 2143 5286025 SGTC_1119 parthenolide 318.541 nM 0.0926760166265503 0.481262702996111 no 1609 0.463080475476517 2168 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2787 5284540 71.43 µM 0.0919413424658316 0.481544307683863 no 1610 0.463372322006108 2141 736958 SGTC_3029 9088683 49.47 µM 0.0913417513072713 0.481774141137713 no 1611 0.46361052194156 2171 25236615 SGTC_309 k408-0051 1.48 µM 0.0904494220748392 0.482116197250131 no 1612 0.463965042234861 2188 3640463 SGTC_3203 9113543 49.47 µM 0.0880594977457651 0.483032389888819 no 1613 0.464914693696075 2164 17018012 SGTC_1263 0774-1208 64.8 µM 0.0864526009059145 0.483648454652012 no 1614 0.465553316967151 2253 906585 SGTC_904 1141-0088 396 µM 0.0854229806963931 0.484043219169089 no 1615 0.46596256199044 2088 1378119 SGTC_2868 9035608 32.47 µM 0.0852710192942396 0.484101483704327 no 1616 0.466022965424948 2258 6462614 SGTC_2328 6201408 200 µM 0.083823232092445 0.484656606303523 no 1617 0.466598488241529 2175 2890418 SGTC_3018 9082602 49.47 µM 0.0837613969185294 0.484680316329568 no 1618 0.466623070457424 2163 17332089 SGTC_975 1335-0046 28.5 µM 0.0831911405950865 0.484898977467369 no 1619 0.466849778551235 2169 16486740 SGTC_3153 9100258 49.47 µM 0.0822681606221222 0.48525289782544 no 1620 0.467216736356899 2175 25236848 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0814715926057367 0.485558354363594 no 1621 0.467533457788215 2220 6708514 SGTC_1578 josamycin 24.2 µM 0.080392244131955 0.485972261003569 no 1622 0.467962647613366 2102 5282165 A P450 substrate. SGTC_2226 7298446 200 µM 0.0802130409078069 0.486040983013267 no 1623 0.46803390921961 2273 3283010 SGTC_3267 9137951 49.47 µM 0.0786903644591044 0.486624925331945 no 1624 0.468639454880999 2127 16643986 SGTC_2980 9014342 25.29 µM 0.0782451378245447 0.486795674022199 no 1625 0.468816528630257 2165 2996599 SGTC_2627 acetyl isogambogic acid 100 µM 0.0775244743794107 0.487072060491072 no 1626 0.46910316106022 2183 6857789 A caspase activator and apoptosis inducer. SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0775213271524609 0.487073267518892 no 1627 0.469104412854941 2241 641818 YHR062C RPP1 SGTC_765 1319-0117 244 µM 0.0756647943977742 0.487785307190951 no 1628 0.469842892834685 2285 3487746 YGL099W LSG1 SGTC_2686 alizarin 95.37 µM 0.0744012125129177 0.488269953652804 no 1629 0.470345572016715 2191 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2398 5228213 48.84 µM 0.0739186257491114 0.488455054274706 no 1630 0.470537567593909 2285 80771 YMR134W ERG29 SGTC_953 1188-0045 9.7 µM 0.0738748545627743 0.488471843242139 no 1631 0.47055498215773 2214 6144426 SGTC_623 k072-0108 16.9 µM 0.0736990813899075 0.488539263371997 no 1632 0.470624914873779 2204 5382803 SGTC_1880 MG-132 525 µM 0.0711554458972954 0.489514944167567 no 1633 0.4716370202563 2278 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1961 st076550 68.7 µM 0.0702813889227387 0.489850227348642 no 1634 0.471984847680622 2226 1579337 SGTC_600 1495-0418 41.6 µM 0.0697812636802566 0.490042075729399 no 1635 0.472183880118353 2232 5377768 SGTC_324 1315-0088 19.6 µM 0.0692372733644564 0.49025075339622 no 1636 0.472400377213535 2274 6787421 SGTC_2974 9094440 9.66 µM 0.0659822962871466 0.491499434217072 no 1637 0.473695960125821 2225 25236134 SGTC_1820 st053765 18.6 µM 0.0659513166268034 0.491511319116005 no 1638 0.473708292360354 2210 3690829 SGTC_1492 4158-0558 28.5 µM 0.0659058976000336 0.491528743482792 no 1639 0.473726372594135 2273 3967268 SGTC_187 1488-2104 32.728 µM 0.0636996760040414 0.492375148001114 no 1640 0.474604681368033 2255 2852859 SGTC_2012 4023501 200 µM 0.0632070043546209 0.492564163535056 no 1641 0.47480083363309 2214 3477460 SGTC_2624 nerol 100 µM 0.0631679369473414 0.492579151980868 no 1642 0.474816388190621 2280 637566 A natural product oil. SGTC_632 0781-2353 4.65 µM 0.0630117460674218 0.49263907565598 no 1643 0.474878575450286 2238 6811515 YHR007C ERG11 SGTC_1687 st020778 55.3625 µM 0.0618297439626195 0.493092563953648 no 1644 0.475349208269422 2221 4259299 SGTC_1808 st050063 61.5 µM 0.0617205625434254 0.493134453082836 no 1645 0.475392682322382 2290 4011993 SGTC_2099 5377090 177.372 µM 0.0615715561044273 0.493191621814912 no 1646 0.475452014445666 2224 2243829 SGTC_2090 5301565 104.445 µM 0.0615436787474878 0.493202317429677 no 1647 0.475463114850472 2251 2056344 SGTC_1433 4060-0023 7.6 µM 0.0613994566260184 0.493257650739283 no 1648 0.475520542547321 2263 3840627 SGTC_509 pifithrin 175 µM 0.0590048722093196 0.494176392588051 no 1649 0.476474113706801 2305 4817 A p53 inhibitor. SGTC_2835 9006588 71.43 µM 0.0584238151794265 0.49439933440745 no 1650 0.476705522699443 2169 2345538 SGTC_1920 st075728 45.7 µM 0.0583885852148914 0.494412851609852 no 1651 0.476719553469939 2304 3400306 SGTC_3327 9140648 26.9345 µM 0.0581730093194617 0.494495564946419 no 1652 0.476805409873074 2292 8029710 SGTC_430 0958-0115 16.4 µM 0.0561922980427175 0.49525554568515 no 1653 0.477594308370757 2142 6833180 SGTC_1956 st077085 54 µM 0.0553570999019282 0.49557600886732 no 1654 0.477926986359166 2257 24208685 SGTC_3016 9080866 49.47 µM 0.055346668743794 0.495580011291896 no 1655 0.4779311414191 2319 17066299 SGTC_2137 5261020 140 µM 0.054699596506821 0.495828293093096 no 1656 0.478188895412019 2304 763655 SGTC_2001 4023502 57.655 µM 0.0535841717581851 0.496256285625235 no 1657 0.478633233750184 2276 108941 YCR052W RSC6 SGTC_2959 9079155 11 µM 0.0529007890829801 0.496518504202899 no 1658 0.478905477840569 2263 16189457 SGTC_161 4065-0411 162.148 µM 0.0528311591239553 0.496545221777817 no 1659 0.47893321738471 2261 1906281 YLR208W SEC13 SGTC_1984 st072354 53.1 µM 0.052307248090474 0.496746251140803 no 1660 0.479141939042048 2234 5762938 SGTC_1955 wogonin 32.4 µM 0.051127447192045 0.497198954275517 no 1661 0.479611982446345 2282 5281703 A flavanone. SGTC_2626 ethyl orsellinate 100 µM 0.0504632607098814 0.497453811869877 no 1662 0.479876612895478 2292 75653 A natural product. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0497707091530489 0.497719554643135 no 1663 0.480152554227052 2272 6708739 YPR165W RHO1 SGTC_2728 chlorpromazine 9.18 µM 0.0495204603874161 0.497815579230714 no 1664 0.480252266085161 2328 2726 A thorazine and dopamine antagonist. SGTC_2572 astragaloside iv 100 µM 0.0494184476375489 0.497854723245569 no 1665 0.480292913517019 2244 45006101 An anti-inflammatory agent. SGTC_1855 st056195 39.6 µM 0.0487065391319862 0.498127895115539 no 1666 0.480576582294579 2334 4028379 SGTC_1571 st070080 73.4 µM 0.0483565191797432 0.498262204284417 no 1667 0.480716055703537 2306 4315245 SGTC_1575 cyproterone acetate 48 µM 0.0480845909054839 0.498366548360049 no 1668 0.480824413338009 2268 9880 An androgen receptor antagonist and liver toxin. SGTC_3309 9129340 25.759 µM 0.0479465566838135 0.498419514772072 no 1669 0.480879417582558 2266 17158987 SGTC_2168 5727979 200 µM 0.0479262031513204 0.498427324820214 no 1670 0.480887528143255 2313 695210 SGTC_3175 9106517 49.47 µM 0.04693305788797 0.498808414738959 no 1671 0.481283290365316 2274 41468073 SGTC_2923 7992654 58.14 µM 0.046804206453938 0.498857857726628 no 1672 0.481334638222109 2303 2985126 SGTC_625 k213-0058 121 µM 0.0457941585224117 0.499245434771312 no 1673 0.481737157375944 2265 3655420 SGTC_2015 5119600 184 µM 0.0451772064019303 0.49948217289984 no 1674 0.481983031176319 2296 2828786 SGTC_1319 1306-0155 43.7 µM 0.0448491599577308 0.499608051631389 no 1675 0.482113770254257 2334 3122360 SGTC_2325 6158266 200 µM 0.0448210560235611 0.499618835739252 no 1676 0.482124970838549 2271 3623240 SGTC_2077 5212015 200 µM 0.0442626119755628 0.49983312325313 no 1677 0.482347536885368 2329 780900 SGTC_322 k048-0136 19.3 µM 0.0440444372887545 0.499916841793249 no 1678 0.482434491190777 2275 6823282 SGTC_3087 9117406 49.47 µM 0.043611008447427 0.499916841793249 no 1679 0.482607238287781 2231 42546093 SGTC_520 3584-0023 682 µM 0.0432084511178351 0.499762371486804 no 1680 0.482767684182024 2159 1340790 SGTC_1907 st060210 83.7 µM 0.042138495238094 0.499351805573042 no 1681 0.483194146324286 2303 688793 SGTC_1932 st074806 40.9 µM 0.0411779061009432 0.498983206687743 no 1682 0.483577033553963 2281 17251235 SGTC_3132 9126706 49.47 µM 0.0411172132340268 0.498959917544246 no 1683 0.483601226015629 2280 850858 SGTC_1041 0206-0046 107 µM 0.0404970855744922 0.498721961593139 no 1684 0.483848415255943 2231 50494 SGTC_271 rotenone 740 µM 0.0404680099215687 0.49871080466758 no 1685 0.483860005262268 2274 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1335 1486-0900 202 µM 0.0386934220879324 0.498029861085672 no 1686 0.484567408948552 2338 X1335 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0381042339938279 0.497803779420622 no 1687 0.484802287762277 2346 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2489 cantharidin 73.42 µM 0.0375787059166697 0.497602125798364 no 1688 0.485011793072294 2324 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3080 9117754 49.47 µM 0.0373363850924817 0.497509143582478 no 1689 0.485108397299335 2359 9550191 SGTC_428 3448-4153 16.5 µM 0.0362046560091061 0.497074883653286 no 1690 0.48555958673335 2332 3834874 SGTC_1185 1319-0113 81.3 µM 0.0359325405393639 0.496970469722979 no 1691 0.485668074507843 2295 4672763 SGTC_234 nsc-17383 10.7 µM 0.0352872029958314 0.496722846903055 no 1692 0.485925363753419 2335 408974 SGTC_1697 st025554 27.742 µM 0.0349196382631134 0.496581808997753 no 1693 0.486071910546286 2337 1269519 SGTC_950 1165-0508 94.1 µM 0.0347881746687191 0.496531365332907 no 1694 0.48612432508626 2298 6148369 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0347731210667825 0.496525589145278 no 1695 0.486130326973225 2316 17037758 SGTC_584 0986-0246 15.4 µM 0.0346622366997784 0.496483041948097 no 1696 0.486174536783983 2348 53315 YDR232W HEM1 SGTC_1811 st050069 61.5 µM 0.0343889303944277 0.496378172357138 no 1697 0.486283505258912 2345 3877702 SGTC_69 0096-0274 206.684 µM 0.0338057194791222 0.496154390989104 no 1698 0.486516037534611 2307 6741392 SGTC_1384 3089-0840 101 µM 0.0332488006433601 0.495940699171057 no 1699 0.486738091164295 2341 1069836 SGTC_2434 5670830 169.91 µM 0.0327119231857566 0.495734698405908 no 1700 0.486952157826683 2309 1549830 SGTC_2076 5212012 200 µM 0.0321356178923074 0.495513570382391 no 1701 0.487181949549606 2358 604802 SGTC_2376 9072922 81.32 µM 0.0319976434905895 0.495460629882447 no 1702 0.487236965079372 2305 17087968 SGTC_3127 9126946 49.47 µM 0.0316330683433151 0.495320743520158 no 1703 0.487382335927165 2252 27243249 SGTC_489 paxilline 115 µM 0.0295100826513693 0.494506172421868 no 1704 0.488228888825861 2258 105008 A toxic potassium channel blocker. SGTC_1182 1222-0449 220 µM 0.0292625690767892 0.494411205047422 no 1705 0.488327589829352 2325 658318 SGTC_1641 st009299 47.1 µM 0.0291253775445542 0.494358566779198 no 1706 0.488382298013496 2365 4046054 SGTC_45 0kpi-0036 14.9 µM 0.0290524311821161 0.494330578428533 no 1707 0.488411387091993 2326 2795021 SGTC_255 tunicamycin 200.472 nM 0.028568828850492 0.494145028673554 no 1708 0.488604236452951 2346 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2595 hexamethylquercetagetin 100 µM 0.0285003309001302 0.494118747309725 no 1709 0.488631552058715 2329 386331 SGTC_1622 st003707 19.4 µM 0.028323561749005 0.494050924458792 no 1710 0.488702044289107 2300 10140899 SGTC_723 4182-0001 115 µM 0.0271322341268971 0.493593840034627 no 1711 0.489177132551627 2313 744821 YLR208W SEC13 SGTC_1120 ficusin 1.78878 µM 0.0266593328330514 0.493412401215249 no 1712 0.489365724645931 2308 6199 A DNA cross-linker. SGTC_757 1066-0008 322 µM 0.0262519705055248 0.493256108930395 no 1713 0.489528181838736 2343 6842497 SGTC_641 4092-0595 30 µM 0.0250753339516565 0.492804675893499 no 1714 0.489997437324993 2343 786260 SGTC_831 k061-1017 217 µM 0.0246314623370986 0.492634380715874 no 1715 0.490174461795967 2353 1240153 SGTC_199 4063-0024 41.6 µM 0.0234416513195548 0.492177906153085 no 1716 0.490648990587825 2344 306215 SGTC_725 1497-0963 19 µM 0.0232661012752848 0.492110556705257 no 1717 0.490719005826838 2360 3549977 SGTC_2937 9044753 11.33 µM 0.0231681127985994 0.492072963706194 no 1718 0.490758087038693 2371 6465530 YGL099W LSG1 SGTC_1677 st019204 53.9 µM 0.0219439134045563 0.49160330914928 no 1719 0.491246347683243 2258 3945625 SGTC_2477 5967686 25.23 µM 0.0219205456359979 0.491594344398132 no 1720 0.491255667832248 2352 776118 SGTC_1234 0326-0494 15.5 µM 0.0216762827104648 0.491500636247191 no 1721 0.491353091491344 2347 1547813 SGTC_543 3844-1095 191 µM 0.0214929749404307 0.491430313020869 no 1722 0.491426203677706 2350 4230703 SGTC_2771 fluoxetine 41.05 µM 0.0206050574263798 0.491089680837311 no 1723 0.491780353040348 2353 3386 A selective serotonin reuptake inhibitor. SGTC_1200 1643-0193 18.4 µM 0.0205954956453513 0.491086012682 no 1724 0.491784166829758 2362 5403974 SGTC_2411 st077133 39.94 µM 0.0193980247910096 0.490626636848881 no 1725 0.492261793050727 2359 1403142 YNL221C POP1 SGTC_2344 7990960 76.95 µM 0.0193628622329357 0.490613147912662 no 1726 0.492275818247638 2348 140813 SGTC_925 2064-1272 59.6 µM 0.0191789464520016 0.490542594966251 no 1727 0.492349176405891 2345 6815817 SGTC_1693 xanthone 101.9 µM 0.0176953569748026 0.489973478040604 no 1728 0.492940942333224 2328 7020 An insecticide. SGTC_2409 alverine citrate 63.97 µM 0.0173631565152374 0.489846046012876 no 1729 0.493073450781684 2342 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_744 1594-0068 283 µM 0.0171932740362076 0.489780879528706 no 1730 0.493141213969532 2359 668392 SGTC_2122 5258151 111.688 µM 0.0171343165562096 0.489758263653946 no 1731 0.49316473113676 2353 2173356 SGTC_3290 9121031 71.43 µM 0.0148244188147793 0.488872221932416 no 1732 0.49408612916192 2370 17014854 SGTC_366 0181-0206 4.31 µM 0.0144823546589705 0.48874101587574 no 1733 0.494222578365525 2378 274874 SGTC_3012 9080433 71.4286 µM 0.0138858456809786 0.488512214963939 no 1734 0.494460527076458 2381 17688859 SGTC_1457 k015-0032 57.3 µM 0.013555135162011 0.488385367083672 no 1735 0.494592449066582 2382 4302660 SGTC_1326 1431-2094 10.8 µM 0.0118447987754394 0.487729366630722 no 1736 0.495274719458114 2391 616278 SGTC_3343 9148379 18.9835 µM 0.0116010247031481 0.487635869614227 no 1737 0.495371964559912 2390 1955036 SGTC_397 arbidol 50 µM 0.0115695847596684 0.48762381119943 no 1738 0.495384506440949 2377 131410 A RNA synthesis inhibitor. SGTC_1211 1056-0033 32.3 µM 0.0109273692872324 0.487377499617324 no 1739 0.495640697133439 2388 6741922 SGTC_1223 0764-0573 147 µM 0.010448365386108 0.487193788380408 no 1740 0.495831781126125 2382 1609797 SGTC_2753 fluvastatin 17.09 µM 0.00999287345292615 0.487019097153193 no 1741 0.49601348662426 2370 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1868 st057644 42.7 µM 0.00769087129513681 0.486136267223977 no 1742 0.496931816514195 2395 688665 SGTC_1568 digitonin 820 nM 0.00746325123270226 0.486048977353982 no 1743 0.497022621174102 2393 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_383 2324-0395 7.37 µM 0.0072146119231885 0.485953627590598 no 1744 0.497121811235761 2382 3146421 SGTC_997 3996-0078 137 µM 0.00649250099781843 0.485676712531905 no 1745 0.497409885043101 2395 735687 SGTC_3238 9133470 49.47 µM 0.00542542343168655 0.485267522367554 no 1746 0.497835579822389 2394 3534688 SGTC_837 0091-0265 12.5 µM 0.00351219201467135 0.484533898353352 no 1747 0.498598840989124 2398 759367 SGTC_2337 9009472 200 µM 0.00333290466310415 0.484465153691155 no 1748 0.498670365874993 2398 5742383 SGTC_1700 st030840 7.9285 µM 0.00122815057105241 0.48365815688227 no 1749 0.49951003893368 2404 5499307 SGTC_539 4859-0462 2.54 µM 7.63477864451332e-05 0.483216565166969 no 1750 0.499969541640002 2405 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2848 9016370 25.97 µM 0 0.483187294775112 no 1751 0.5 2406 7894410 SGTC_2750 bromebric acid 70.15 µM -0.0001037773324987 0.483147508525445 no 1752 0.499958598834393 2406 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_278 4092-0821 23.9 µM -0.00119548918735101 0.482728977269605 no 1753 0.499523068931007 2402 877900 SGTC_1361 1608-0041 5.61 µM -0.00271013305646223 0.48214833753353 no 1754 0.498918814661783 2410 X1361 SGTC_969 1313-0238 134 µM -0.00293248839957426 0.482063100622481 no 1755 0.498830108067369 2408 5212874 SGTC_538 2922-0838 53.3 µM -0.00400753933994804 0.481651006031154 no 1756 0.498401227396404 2412 777039 SGTC_2696 st077691 74.316 µM -0.00470489221730836 0.481383703248059 no 1757 0.498123026494571 2426 757133 SGTC_203 k066-0004 30.888 µM -0.00481342393977355 0.481342102632835 no 1758 0.498079729092073 2406 6795412 SGTC_3328 9140624 29.0385 µM -0.0058775712644148 0.480934221815245 no 1759 0.497655201817066 2412 4904392 SGTC_606 k015-0008 38.6 µM -0.00622614779877717 0.480800618993035 no 1760 0.497516142446805 2419 1970475 SGTC_2862 9027634 71.43 µM -0.00703074439293203 0.480492240527299 no 1761 0.497195161906813 2423 5012562 SGTC_2475 5812728 15.03 µM -0.00747773982818177 0.480320925214407 no 1762 0.497016841222068 2415 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2372 9071633 200 µM -0.00775495822022686 0.480214680415321 no 1763 0.496906250292599 2425 21321366 SGTC_585 0kpi-0023 191 µM -0.00895041535728694 0.479756533995401 no 1764 0.496429348560997 2416 64601 SGTC_3174 9107204 49.47 µM -0.00953586896807131 0.479532174751954 no 1765 0.496195796342836 2427 3938802 SGTC_2493 resveratrol 26.09 µM -0.0100533877443387 0.479333855091663 no 1766 0.495989346127496 2414 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1219 1469-0211 33.1 µM -0.0104507234679006 0.47918159454789 no 1767 0.495830840438957 2425 6822282 SGTC_2253 7938677 135.83 µM -0.0111785439292897 0.47890269890453 no 1768 0.495540499069899 2434 2301972 SGTC_701 4424-0219 185 µM -0.0126115289714698 0.478353619509375 no 1769 0.494968861240786 2429 2911779 SGTC_635 k038-0028 24.7 µM -0.0130947466050304 0.478168473370793 no 1770 0.494776101220937 2434 4035102 SGTC_2505 galangin 7.89 µM -0.0133427734544945 0.478073443042237 no 1771 0.494677161468792 2431 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_496 calpeptin 138 µM -0.0133436269930192 0.478073116015089 no 1772 0.494676820986498 2462 73364 A calpain inhibitor. SGTC_1036 k216-0215 33.5 µM -0.0139000098752742 0.477859945065956 no 1773 0.494454876925789 2428 622330 SGTC_2375 9072683 200 µM -0.0141696837095016 0.47775662527833 no 1774 0.494347303227014 2429 16798029 SGTC_1761 st044296 37 µM -0.0143092948344187 0.477703136835341 no 1775 0.494291612092854 2427 1826700 SGTC_479 n-linoleoylglycine 10 µM -0.0143262009630193 0.47769665971045 no 1776 0.494284868214633 2431 6433346 An anti-infammatory. SGTC_1572 epiandrosterone 68.9 µM -0.0148723984282409 0.477487402137136 no 1777 0.494066990175467 2433 441302 A steroid. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0149461468020419 0.477459148350483 no 1778 0.494037572100854 2431 165521 SGTC_828 2074-0507 139 µM -0.0154604993960265 0.477262097557776 no 1779 0.493832398819694 2457 X828 SGTC_3300 9124615 50.48 µM -0.016067901520568 0.477029406233804 no 1780 0.493590110542135 2452 24824903 SGTC_2675 theaflavin digallate 100 µM -0.0162646280121732 0.476954043424875 no 1781 0.493511638282044 2454 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1364 1653-0028 37.6 µM -0.0181644154648246 0.476226307697318 no 1782 0.492753845147783 2455 5718652 SGTC_98 0074-0023 107.663 µM -0.0188631210365774 0.475958680198251 no 1783 0.492475149726188 2459 3563821 SGTC_2781 5567276 71.43 µM -0.0191087121788773 0.475864613182968 no 1784 0.492377190693072 2462 2853274 SGTC_3045 9092950 49.47 µM -0.019458707193581 0.475730559426317 no 1785 0.492237588843177 2440 44120432 SGTC_2185 6113692 200 µM -0.0196182192759683 0.475669464626813 no 1786 0.492173964874778 2461 874150 SGTC_2610 ononetin 44.17 µM -0.0197208168449458 0.475630168984698 no 1787 0.4921330422837 2455 259632 SGTC_2331 7980721 200 µM -0.0224057907918592 0.474601889133451 no 1788 0.491062130564287 2480 2981221 SGTC_1795 st049545 62.3 µM -0.0224532609843098 0.474583710703677 no 1789 0.491043197460528 2445 5291882 SGTC_2082 5219693 150 µM -0.0232239200666915 0.474288598790204 no 1790 0.490735829148692 2438 2834649 SGTC_1776 st049249 45.9 µM -0.023863505599581 0.474043690160391 no 1791 0.490480742150013 2462 1822314 SGTC_2121 5257820 149.641 µM -0.024786574064473 0.473690248213087 no 1792 0.490112600057072 2447 791256 SGTC_7 0192-1582 4.227 µM -0.0257494151185327 0.473321599454476 no 1793 0.489728604670764 2449 252616 SGTC_3324 9138759 60.749 µM -0.0265940186490142 0.47299823980975 no 1794 0.489391772000287 2518 45595710 SGTC_2019 4016004 108 µM -0.0267513539469352 0.472938005357603 no 1795 0.489329026621323 2484 45595336 SGTC_2971 9092186 9.93 µM -0.0268359603561092 0.472905614784533 no 1796 0.489295285661014 2463 25236400 SGTC_492 tmb-8 126 µM -0.0270640701898117 0.472818286498977 no 1797 0.489204316045738 2447 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3278 9139605 49.47 µM -0.027904465089092 0.472496565748706 no 1798 0.488869173602729 2583 7958859 SGTC_2162 5663267 200 µM -0.0295901648052153 0.471851298929801 no 1799 0.488196954614473 2466 6456493 SGTC_1368 1852-0141 284 µM -0.0302947803050182 0.471581601869058 no 1800 0.487915979688489 2469 2838987 SGTC_1376 2910-0861 41.3 µM -0.0307384087635363 0.471411806304668 no 1801 0.487739079930286 2472 1112859 SGTC_1802 st050112 57.9 µM -0.0308256764061865 0.471378405860117 no 1802 0.487704281668109 2444 4662563 SGTC_704 1310-0270 142 µM -0.0311615178685544 0.471249869214426 no 1803 0.487570364645888 2501 5718033 SGTC_1583 clindamycin 39.6 µM -0.0312028373852284 0.471234055197171 no 1804 0.487553888555713 2467 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_566 0958-0068 16.5 µM -0.0322041863971442 0.470850827697389 no 1805 0.487154608825082 2472 6815365 SGTC_2809 7964133 12.99 µM -0.0330936036553138 0.470510460359301 no 1806 0.486799971750697 2483 1253665 SGTC_3253 9135987 49.47 µM -0.0348484069942169 0.469838985489565 no 1807 0.486100310426035 2473 4182430 SGTC_783 0848-0141 92.7 µM -0.0359708944220936 0.469409510931626 no 1808 0.485652783407672 2475 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1995 st072814 61.1 µM -0.036044129597041 0.469381491675943 no 1809 0.485623585734105 2481 5769371 SGTC_895 0964-0006 13.7 µM -0.0382750603228789 0.468528026802806 no 1810 0.484734187595522 2467 6738897 SGTC_2568 diosmetin 100 µM -0.040217228642996 0.467785148487517 no 1811 0.483959971135479 2475 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_930 2810-3379 265 µM -0.0402761325318736 0.467762619522054 no 1812 0.483936490908012 2480 1015764 SGTC_1829 berberine 14.4 µM -0.0410773040160127 0.467456205814524 no 1813 0.483617134050184 2580 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_510 ag-490 170 µM -0.0411052653572838 0.467445512148732 no 1814 0.483605988502502 2480 5328779 SGTC_1941 st076221 61.8 µM -0.0425303102508205 0.466900542613188 no 1815 0.483037974758802 2474 2828568 SGTC_3272 9137413 49.47 µM -0.0438308616761042 0.466403236331381 no 1816 0.482519613328028 2475 17614870 SGTC_46 0329-0187a 2.197 µM -0.045710310156264 0.465684663624464 no 1817 0.48177057304207 2498 46494817 SGTC_3353 9151644 39.2805 µM -0.0460584393284359 0.465551575020748 no 1818 0.48163183572095 2547 4909158 SGTC_1875 nocodazole 6 µM -0.0462264232666728 0.46548735670717 no 1819 0.481564891130251 2483 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_193 1273-0060 1.558 µM -0.0464802862149732 0.465390309548864 no 1820 0.48146372321181 2480 2847393 YHR072W ERG7 SGTC_928 2764-0428 58.7 µM -0.0476051873088372 0.464960305298606 no 1821 0.481015448922112 2606 662578 SGTC_2240 6690706 185.951 µM -0.0476498568692815 0.4649432307713 no 1822 0.480997648546274 2475 805876 SGTC_1194 1488-0194 225 µM -0.0488444138324878 0.464486646437834 no 1823 0.480521643636905 2487 1391452 SGTC_1783 st039459 87.517 µM -0.0489198811090587 0.464457802850753 no 1824 0.480491572497929 2596 729761 SGTC_2133 5320837 200 µM -0.0500082111767607 0.464041864029699 no 1825 0.480057922468891 2540 2841355 SGTC_1654 st012436 41.8 µM -0.0522848893582042 0.463171889029627 no 1826 0.479150846696676 2504 4323132 SGTC_279 1273-0055 2.93 µM -0.0527406014307915 0.462997771203934 no 1827 0.478969294380735 2507 2847562 SGTC_2245 6637752 200 µM -0.053214182502721 0.462816833527858 no 1828 0.478780627811738 2524 681890 SGTC_2447 5741742 33.78 µM -0.0536642550143118 0.462644884725424 no 1829 0.478601331055359 2557 1776504 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.0551474736099528 0.462078275253854 no 1830 0.478010487595719 2489 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1406 3909-7906 11.9 µM -0.055295684773535 0.462021660803936 no 1831 0.477951449980177 2515 X1406 SGTC_50 0929-0078 56.389 µM -0.0553274352544284 0.462009532694688 no 1832 0.477938802732028 2606 1377751 SGTC_1070 indatraline 8.81 µM -0.055636260394608 0.461891568923094 no 1833 0.477815788805539 2523 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1725 st036284 20.55 µM -0.0566445506709447 0.461506449695892 no 1834 0.477414172595288 2510 707914 SGTC_780 0109-0199 192 µM -0.056854200182735 0.46142637801241 no 1835 0.477330669110574 2510 610414 SGTC_443 clozapine 122 µM -0.0571313306987141 0.461320535630099 no 1836 0.47722028944282 2497 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1423 4048-0112 5.59 µM -0.05734879757814 0.461237482051676 no 1837 0.477133674719809 2524 X1423 SGTC_1480 1070-0044 41.2 µM -0.0590279756935675 0.46059623813821 no 1838 0.476464912787188 2604 3124987 SGTC_1084 voriconazole 435 nM -0.0602104825570496 0.460144724238976 no 1839 0.475993998495245 2516 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1434 4073-0095 163 µM -0.0608611025682248 0.45989632136166 no 1840 0.475734913822588 2518 24133745 SGTC_3002 9075603 71.4286 µM -0.0609888859575412 0.459847536254344 no 1841 0.475684030149984 2509 20105405 SGTC_1979 st071809 45.3 µM -0.0611869782399296 0.459771909832319 no 1842 0.475605150080417 2631 4976333 SGTC_1809 st050081 57.6 µM -0.0624782981348333 0.45927895365938 no 1843 0.475090971874944 2601 5036894 SGTC_2442 5158906 48.48 µM -0.0626267873247246 0.459222272507688 no 1844 0.475031849040712 2603 1893835 SGTC_1469 k284-2957 126 µM -0.0634939994829332 0.458891257705062 no 1845 0.474686568661743 2561 23884841 SGTC_1838 st055369 84.5 µM -0.0648139328279838 0.458387494044555 no 1846 0.474161073992057 2510 676036 SGTC_3334 9142812 21.919 µM -0.065023989948334 0.458307330121297 no 1847 0.474077449727441 2608 45283678 SGTC_2354 9060492 162 µM -0.066053626543455 0.457914415356632 no 1848 0.473667565415528 2564 6471895 SGTC_2583 asiatic acid 100 µM -0.0685430420990202 0.456964611883628 no 1849 0.472676678989724 2610 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2596 sinensetin 100 µM -0.0687208283066303 0.456896789254562 no 1850 0.472605919402076 2571 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2112 5488546 200 µM -0.069467840935846 0.456611829483225 no 1851 0.472308615004476 2528 600757 SGTC_893 0958-0369 48.9 µM -0.0701241488671998 0.456361488859284 no 1852 0.472047422997743 2677 6819948 SGTC_1426 4048-4480 71.7 µM -0.0705051037844042 0.456216186209268 no 1853 0.471895819214546 2545 14224343 SGTC_79 0052-0007 94.094 µM -0.071048680164954 0.456008867124275 no 1854 0.47167950609152 2544 2801472 SGTC_1653 st012112 65 µM -0.073007829637153 0.455261750701843 no 1855 0.470899943495363 2593 720429 SGTC_3336 9143619 71.43 µM -0.0736709242382652 0.455008917047593 no 1856 0.470636117498535 2517 45595730 SGTC_1562 morin hydrate 59.1 µM -0.0740402273068482 0.454868112086594 no 1857 0.470489188161741 2642 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2472 5377652 49.4 µM -0.074543301123604 0.454676313196394 no 1858 0.470289043835897 2578 1610903 SGTC_1964 st076914 61 µM -0.0751704398016926 0.454437228886686 no 1859 0.470039551706717 2521 24208661 SGTC_1212 0520-0165 585 µM -0.0758592056883905 0.454174669435978 no 1860 0.469765556221456 2745 5403258 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0764458550981158 0.453951052853452 no 1861 0.469532194609697 2548 689007 SGTC_2369 9071472 200 µM -0.0765533595448642 0.45391007633592 no 1862 0.469489431851715 2638 17296037 SGTC_2181 6316240 54.2555 µM -0.0780031103301422 0.453357535767202 no 1863 0.468912789423832 2593 12779990 SGTC_2413 inermin 26.06 µM -0.0781524309173065 0.45330063062566 no 1864 0.468853400426267 2748 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1976 st070609 63.5 µM -0.0782723139258765 0.453254944655057 no 1865 0.468805720083233 2515 682556 SGTC_3234 9132280 49.47 µM -0.0795249436627335 0.452777619667932 no 1866 0.468307546132384 2612 17612295 SGTC_478 N-arachidonylglycine 10 µM -0.0795555008235785 0.452765976457187 no 1867 0.468295394090658 2553 5283389 SGTC_1797 st048695 56.8 µM -0.0809007935878867 0.452253419254803 no 1868 0.467760424422076 2543 592262 YIL048W NEO1 SGTC_460 trequinsin 123 µM -0.0812762562821721 0.452110381949326 no 1869 0.467611128124848 2543 5537 A vasodilator. SGTC_1766 st045414 44.774 µM -0.0814286806259918 0.452052315722972 no 1870 0.467550520499219 2553 253960 SGTC_2702 st077768 96.8 µM -0.0821186841122424 0.451789470961959 no 1871 0.467276167764996 2626 6484119 SGTC_1031 k035-0009 16 µM -0.0828644412650129 0.451505411582036 no 1872 0.466979664262981 2670 5180959 SGTC_2118 5526350 200 µM -0.0830456423983485 0.45143639569741 no 1873 0.466907623771389 2675 743594 SGTC_848 0368-0089 85.6 µM -0.0832165318027883 0.451371308688833 no 1874 0.466839683927404 2546 762535 SGTC_788 1182-0090 188 µM -0.0835877648246386 0.451229920890299 no 1875 0.466692097572919 2769 5715185 SGTC_2531 methyl deoxycholate 70.07 µM -0.0849256946969836 0.450720408414566 no 1876 0.466160232081603 2575 16667744 Haematoxylin. SGTC_1193 1488-0126 41.5 µM -0.0851678904258592 0.450628183726239 no 1877 0.466063958766163 2589 1384710 SGTC_2037 5169046 200 µM -0.085237934700978 0.450601512359364 no 1878 0.466036116388337 2638 5718022 SGTC_192 3455-0609 60.9 µM -0.087399299631502 0.449778620890332 no 1879 0.46517706303147 2659 3769639 SGTC_451 chloral hydrate 100 µM -0.0875588842325798 0.449717871130559 no 1880 0.465113641122705 2653 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3292 9120825 59.784 µM -0.0876083781279321 0.449699030314863 no 1881 0.465093971501864 2559 24824900 SGTC_1705 st027868 56.3335 µM -0.0893188286459179 0.449047983955887 no 1882 0.464414265389607 2643 292948 SGTC_1222 0366-0074 1.18 µM -0.0893892272020193 0.44902119118002 no 1883 0.464386292322773 2625 286520 SGTC_971 1315-0384 26.7 µM -0.0903980652713302 0.448637266111053 no 1884 0.463985447044924 2605 6769120 SGTC_2189 6047310 154.431 µM -0.0907412039681587 0.448506691629602 no 1885 0.463849114816627 2545 711535 SGTC_1464 k208-0027 110 µM -0.0923595935229548 0.447890921689991 no 1886 0.463206170929826 2581 X1464 SGTC_809 3998-0021 90 µM -0.0928798249689305 0.447693008990505 no 1887 0.462999516897972 2559 715485 SGTC_2305 7443522 69.23 µM -0.0934640485038314 0.447470767176476 no 1888 0.462767454887462 2597 5415886 SGTC_553 k007-0256 45.7 µM -0.0946806270240701 0.447008027087997 no 1889 0.46228425311757 2623 6287000 SGTC_433 pimozide 108 µM -0.0950851776431846 0.446854167406195 no 1890 0.462123585628174 2568 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2581 avocatin a 64 µM -0.0955326632793243 0.446683987892173 no 1891 0.461945873674356 2622 6710728 A skin care supplement. SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0960073146345302 0.446503487942011 no 1892 0.461757381581632 2575 2724 A muscle relaxant with antifungal properties. SGTC_1123 mangostin 811.285 nM -0.0976317125331431 0.445885847603274 no 1893 0.461112370917015 2670 5281650 An antioxidant. SGTC_978 1416-0512 87.4 µM -0.097821972856888 0.445813514005216 no 1894 0.461036829622286 2619 6814003 SGTC_447 ml7 120 µM -0.0980571544374823 0.445724104635365 no 1895 0.460943454655794 2617 4216 Selective myosin light chain kinase inhibitor. SGTC_2564 betulinic acid 100 µM -0.0987215929594572 0.445471518874496 no 1896 0.460679661955033 2644 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2034 5197015 53.07 µM -0.0989669189008652 0.44537826400752 no 1897 0.460582268007313 2684 780676 SGTC_665 3914-0008 307 µM -0.0995784309701992 0.445145825292893 no 1898 0.46033950914571 2577 1069549 SGTC_693 4161-2696 114 µM -0.0997562027824042 0.445078256895923 no 1899 0.460268939828299 2690 805759 SGTC_3266 9136860 49.47 µM -0.10009719623898 0.444948654869627 no 1900 0.460133580615866 2591 4871271 YPR165W RHO1 SGTC_3151 9099821 49.47 µM -0.10029335048387 0.444874104820913 no 1901 0.460055718210726 2689 17174189 SGTC_465 cgp-37157 41 µM -0.100629409272191 0.444746387422456 no 1902 0.459922324988057 2558 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_206 4546-0025 72.014 µM -0.101274463580141 0.444501253963372 no 1903 0.459666293531393 2607 6620745 YIL048W NEO1 SGTC_2466 5983409 37.09 µM -0.104157557473713 0.443405881731396 no 1904 0.458522157469813 2639 2879657 SGTC_2233 sulbentine 40.3845 µM -0.105293291756156 0.442974501075437 no 1905 0.458071542895379 2591 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1152 3909-8331 15.9 µM -0.106291039278448 0.442595587037944 no 1906 0.457675720467885 2604 16001939 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.108081193442671 0.441915872991323 no 1907 0.456965643106766 2698 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2819 7996655 46.38 µM -0.108183115111941 0.44187717888589 no 1908 0.456925219264948 2667 6456960 SGTC_2451 5856223 45.7 µM -0.109872708305803 0.441235813474178 no 1909 0.45625516354586 2640 2179896 SGTC_528 3492-0019 172 µM -0.110532816402533 0.440985279832424 no 1910 0.45599341279222 2580 2869262 SGTC_3319 9138450 16.7555 µM -0.112806942107015 0.440122352645166 no 1911 0.455091807236451 2635 2029690 SGTC_1163 k060-0048 49.9 µM -0.114225549103077 0.439584199611174 no 1912 0.454529499600286 2605 6809982 SGTC_2089 5281248 129.67 µM -0.115172582614193 0.43922500153417 no 1913 0.454154164971601 2611 2737878 SGTC_364 0083-0097 67.7 µM -0.115437747655259 0.439124436673226 no 1914 0.454049080317806 2738 5207356 SGTC_1939 st074455 53.6 µM -0.116316532455081 0.43879118228341 no 1915 0.453700841771406 2772 1644229 SGTC_2887 9044784 58.44 µM -0.118411651190186 0.437996842955148 no 1916 0.452870747206758 2629 6465546 SGTC_554 4483-2211 187 µM -0.118571151721472 0.437936380418394 no 1917 0.452807560836792 2712 747107 SGTC_2499 avocadenofuran 51.48 µM -0.118690167718745 0.437891265467959 no 1918 0.452760413252914 2620 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2000 st075254 36.4 µM -0.119599092913447 0.437546749249876 no 1919 0.45240036915861 2618 17234175 SGTC_833 3852-0053 558 µM -0.119850661641477 0.437451403764706 no 1920 0.452300724477874 2745 3123681 SGTC_667 1498-1044 59 µM -0.119888441571808 0.437437085343909 no 1921 0.452285760360951 2666 6739982 SGTC_2916 7875993 68.79 µM -0.12119277378455 0.436942799771571 no 1922 0.451769173807027 2635 1299250 SGTC_2469 5655019 90.81 µM -0.122335512198489 0.436509832127649 no 1923 0.451316654269828 2785 2788239 SGTC_818 4072-2707 53.5 µM -0.122565173453211 0.436422825843826 no 1924 0.451225717007924 2623 882871 SGTC_1643 st009866 20.2 µM -0.125127155896819 0.435452438139458 no 1925 0.450211442473952 2650 3156273 YOR207C RET1 SGTC_2278 7948257 134.34 µM -0.125264356441623 0.435400482368824 no 1926 0.450157134657634 2620 1247028 SGTC_16 erodoxin 22.806 µM -0.126395552332709 0.434972158178121 no 1927 0.449709411321491 2632 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2366 9070441 60.58 µM -0.126493600586816 0.434935036064395 no 1928 0.449670607175464 2650 6837235 SGTC_2700 st077718 96.8 µM -0.12708428417716 0.434711409109867 no 1929 0.449436845006058 2699 904970 SGTC_391 gliotoxin 8.33 µM -0.128787388834111 0.434066747731885 no 1930 0.448762942337361 2755 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_992 3909-8734 162 µM -0.12897426618528 0.433996021318324 no 1931 0.448689005671715 2678 4288319 SGTC_2488 5268135 45.7 µM -0.131364005188093 0.43309177736473 no 1932 0.447743680782943 2751 1270356 YLR208W SEC13 SGTC_594 1487-1584 10.8 µM -0.131522957565716 0.433031644368091 no 1933 0.447680813403655 2674 5013332 SGTC_927 2425-1185 123 µM -0.132422109722006 0.432691516918608 no 1934 0.447325213821133 2611 730375 SGTC_1413 3910-0535 34.4 µM -0.132784958668519 0.432554274071388 no 1935 0.447181725128499 2761 2876951 SGTC_73 0327-0325 16.231 µM -0.132795949857452 0.432550116925451 no 1936 0.447177378768295 2819 53298 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.134123738394724 0.432047968746878 no 1937 0.446652364356621 2641 5106787 A p450 inhibitor. SGTC_2775 cyproheptadine 69.59 µM -0.134212347890553 0.432014461964632 no 1938 0.446617331024212 2646 2913 A selective serotonin reuptake inhibitor. SGTC_1789 tunicamycin 25 nM -0.134600332594843 0.431867755245022 no 1939 0.446463939314265 2751 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1239 0337-0584 35.4 µM -0.135429293410005 0.431554335937772 no 1940 0.446136232344164 2783 914301 YML130C ERO1 SGTC_534 k292-0788 63.4 µM -0.135798372274637 0.431414805867374 no 1941 0.445990338939226 2627 4146317 SGTC_167 3672-0051 66.205 µM -0.137550780715447 0.430752425849069 no 1942 0.445297728472594 2638 3237971 SGTC_418 lividomycin a 100 µM -0.138443825688877 0.430414945124506 no 1943 0.44494483128962 2667 72394 An antibiotic. SGTC_503 tyrphostin 8 294 µM -0.13887748369508 0.430251084550706 no 1944 0.444773481967902 2654 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_536 3852-0578 10.6 µM -0.140304702258102 0.429711885445524 no 1945 0.444209624605878 2825 2869208 SGTC_1459 k035-0031 35.7 µM -0.14175059348251 0.42916576552861 no 1946 0.443638505284246 2638 3877128 YMR208W ERG12 SGTC_2970 9090938 41.86 µM -0.14262791263555 0.428834463970192 no 1947 0.443292025877654 2777 17217104 SGTC_2179 6298986 200 µM -0.143017542187922 0.428687344435942 no 1948 0.443138163474521 2744 738374 SGTC_2814 7977482 42.97 µM -0.14309395609569 0.428658492605062 no 1949 0.443107989079694 2792 6456762 SGTC_1917 st066507 28.5 µM -0.143106483849426 0.428653762499467 no 1950 0.443103042140146 2664 3156428 SGTC_236 1509-0011 5.31 µM -0.145206670739467 0.427860940052832 no 1951 0.442273849634512 2732 3107280 SGTC_2703 st077852 53.4 µM -0.146928862852102 0.427211028095344 no 1952 0.44159408494596 2799 6281836 SGTC_2755 lomerizine 42.69 µM -0.148388774669241 0.426660248723613 no 1953 0.441017979257828 2711 3949 A calcium channel blocker. SGTC_2292 7671323 168.05 µM -0.149241291243341 0.426338686760349 no 1954 0.440681619555194 2806 937504 SGTC_338 4055-0136 114 µM -0.149731157112772 0.42615393567934 no 1955 0.440488362729151 2673 2900563 SGTC_3248 9135562 49.47 µM -0.149752945671008 0.426145718582216 no 1956 0.44047976726099 2702 17650701 SGTC_57 miconazole 162.5 nM -0.14981816329222 0.426121123317747 no 1957 0.440454039430438 2633 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_334 1502-1024 68.5 µM -0.150954921150993 0.425692468545836 no 1958 0.44000563800767 2775 3296216 SGTC_2487 5918373 44.05 µM -0.15180678778273 0.425371299615344 no 1959 0.439669664155921 2659 2876279 SGTC_1657 st012939 43.4 µM -0.152028794789424 0.425287607134915 no 1960 0.439582112331233 2805 24207257 SGTC_2252 omeprazole 400 µM -0.152590157303716 0.425075999016145 no 1961 0.439360743715709 2741 4594 A proton pump inhibitor. SGTC_1982 st072467 71.9 µM -0.152615833770795 0.425066320672428 no 1962 0.439350618868483 2648 3163533 SGTC_2944 9067346 25.62 µM -0.153503475782737 0.42473176567042 no 1963 0.439000624757779 2824 6473075 SGTC_3106 9121286 49.47 µM -0.154548106600076 0.424338110562387 no 1964 0.438588791617759 2891 15943471 SGTC_1196 1588-0294 184 µM -0.156039273480677 0.423776315169576 no 1965 0.438001032297343 2734 6144269 SGTC_1944 st076371 56.9 µM -0.157205819203561 0.423336928341175 no 1966 0.437541321133394 2689 24208455 SGTC_1489 4065-0444 182 µM -0.157423769561295 0.423254846511935 no 1967 0.437455440803646 2686 2877968 SGTC_1416 3966-0321 25.3 µM -0.157616434572108 0.423182290117892 no 1968 0.437379526269288 2745 582530 YLR208W SEC13 SGTC_2991 9074669 71.4286 µM -0.158111944914422 0.422995696107289 no 1969 0.437184294164511 2833 17333109 SGTC_683 panaxydol 45 µM -0.158424493673494 0.422878008703377 no 1970 0.437061157167273 2738 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1929 genistein trimethyl ether 50.5 µM -0.158601067750599 0.422811524375977 no 1971 0.436991593750829 2705 136420 SGTC_1290 0986-0249 10.2 µM -0.162584058654715 0.421312421482279 no 1972 0.435422969663411 2737 53329 SGTC_2896 9052656 71.43 µM -0.164353956299816 0.420646638686911 no 1973 0.434726254074023 2719 6469436 SGTC_2068 5226020 147 µM -0.164414465284588 0.420623881009437 no 1974 0.434702438440282 2726 1810509 SGTC_2716 st080858 38.6235 µM -0.164717639670424 0.420509859874938 no 1975 0.434583116091877 2809 5296050 SGTC_2761 levamisole 97.89 µM -0.166405240266945 0.419875290755186 no 1976 0.433919025157208 2792 26879 An alkaline phosphatase inhibitor. SGTC_1529 apigenin 74 µM -0.16739828196664 0.419501985884153 no 1977 0.433528338447552 2920 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_628 1636-0253 16 µM -0.167541729996521 0.419448066788801 no 1978 0.433471907869648 2796 4456143 SGTC_985 1493-0307 8.71 µM -0.167598124189967 0.419426869812513 no 1979 0.433449723503204 2781 3278274 SGTC_323 4013-0906 34.3 µM -0.171615711871088 0.417917377940287 no 1980 0.431869827216645 2822 2910086 SGTC_2706 st078239 82.5 µM -0.172598429680514 0.4175483333642 no 1981 0.431483543153382 2711 15434492 SGTC_2347 9049783 174.81 µM -0.173391736261019 0.417250472215779 no 1982 0.431171760117727 2858 6467988 YPL169C MEX67 SGTC_2982 9019404 25.97 µM -0.174061818816738 0.416998914717479 no 1983 0.430908439630131 2741 22333232 SGTC_1309 pyrazolanthrone 13.4 µM -0.17434276634353 0.416893453552734 no 1984 0.430798045588822 2791 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1675 st018485 24.5 µM -0.175144151056065 0.416592665260162 no 1985 0.430483183438586 2797 3323024 SGTC_1332 1480-0653 17.5 µM -0.175394717497575 0.416498628741438 no 1986 0.430384745538056 2670 5749438 SGTC_2885 9057732 51.95 µM -0.176875680059795 0.415942927561521 no 1987 0.429803020955804 2862 6471414 SGTC_1661 st013063 9.66 µM -0.177996686235082 0.415522404381974 no 1988 0.429362789093313 2730 721395 SGTC_1581 himbacine 57.9 µM -0.178207983018469 0.415443151415233 no 1989 0.429279820267408 2720 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1003 4049-0218 100 µM -0.178479485295611 0.415341321687724 no 1990 0.429173215445255 2879 295161 SGTC_414 piperonyl butoxide 100 µM -0.180288949341619 0.41466280909121 no 1991 0.428462865336595 2723 5794 A potent inhibitor of cytochrome P450. SGTC_1977 st070720 65.3 µM -0.180824479001552 0.414462044969815 no 1992 0.428252674183939 2833 682188 SGTC_2339 9000433 200 µM -0.181155147916827 0.414338092020925 no 1993 0.428122899411926 2787 2988954 SGTC_1064 honokiol 6.76 µM -0.181213724788454 0.414316135067515 no 1994 0.428099911063367 2803 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1382 3002-2117 298 µM -0.183432668396548 0.413484584086593 no 1995 0.427229272516927 2838 1497314 SGTC_2532 xanthone 78.9 µM -0.18398723128242 0.413276821618514 no 1996 0.427011735943085 2843 7020 An insecticide. SGTC_3209 9113616 49.47 µM -0.185139497972837 0.412845211995933 no 1997 0.426559811089836 2878 16649353 SGTC_484 loperamide 105 µM -0.185469114792546 0.412721765322222 no 1998 0.426430551404323 2694 3955 An opioid-receptor agonist. SGTC_358 0075-0058 9.45 µM -0.18660119518169 0.41229784924791 no 1999 0.425986664794212 2649 1069125 SGTC_1383 3049-0032 20.7 µM -0.189465570727489 0.411225720075734 no 2000 0.424863968466765 2893 712864 SGTC_3352 9151559 45.5865 µM -0.191002097926315 0.410650874046698 no 2001 0.424261974755204 2829 17159339 SGTC_2264 7948757 110.76 µM -0.19117668420137 0.410585569891925 no 2002 0.424193585007894 2725 2971411 SGTC_1765 st044815 90.4 µM -0.19356491472983 0.409692499706974 no 2003 0.423258286272125 2833 645695 SGTC_221 trifluoperazine 10.304 µM -0.194165519532296 0.40946797922883 no 2004 0.423023140238046 2763 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_426 0988-0037 14.6 µM -0.194519691033527 0.40933559533943 no 2005 0.42288448948543 2739 5383008 SGTC_3235 9132602 49.47 µM -0.194611869810773 0.409301142017499 no 2006 0.422848404983369 2843 4912240 SGTC_256 clotrimazole 625 nM -0.194991329192912 0.409159320263092 no 2007 0.422699867819213 2741 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_455 paf C-16 10 µM -0.195103755733833 0.409117303478303 no 2008 0.422655861214351 2738 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_614 0462-0418 107 µM -0.195853979093633 0.408836951834696 no 2009 0.422362229465973 2769 5188303 SGTC_29 0299-0004 12.984 µM -0.197542097334587 0.408206288145041 no 2010 0.421701670751367 2728 16871 A napthoquinone isolated from Swertia calycina. SGTC_839 0122-0028 230 µM -0.198045614019264 0.408018225417772 no 2011 0.421504687816297 2763 759448 SGTC_3322 9139058 2.11 µM -0.199543097225789 0.407459043058108 no 2012 0.420918967210054 2932 4908926 YPR165W RHO1 SGTC_3289 9119912 71.43 µM -0.200001836093346 0.407287780853378 no 2013 0.42073957257014 2866 17014829 SGTC_1229 0139-0193 12.2 µM -0.20025801340252 0.407192149204908 no 2014 0.420639398909175 2865 3090752 SGTC_1767 st044992 70.3 µM -0.201663735122028 0.406667488281564 no 2015 0.420089807625966 2813 9600693 SGTC_2273 7815444 169.05 µM -0.20171223520653 0.406649389461161 no 2016 0.420070848450927 2972 2824616 SGTC_2841 9004761 38.96 µM -0.202166701207471 0.406479805665959 no 2017 0.419893202098564 2778 2991039 SGTC_754 3474-0146 171 µM -0.203562075245657 0.405959232164304 no 2018 0.419347866056797 2747 24762078 SGTC_3244 9134489 49.47 µM -0.206709357730383 0.404785684179709 no 2019 0.418118424413742 2843 16584271 SGTC_1220 1838-0075 193 µM -0.207103002852054 0.404638963130551 no 2020 0.417964708501379 2794 5529645 SGTC_2069 5228469 200 µM -0.211683412348926 0.402932724630912 no 2021 0.416177014937545 2905 2835210 SGTC_3116 9124943 49.47 µM -0.211823046544132 0.402880738641279 no 2022 0.416122543969539 2789 41905195 YPL160W CDC60 SGTC_289 k017-0060 526 µM -0.213937229979064 0.402093835737022 no 2023 0.415298003481869 2791 5512909 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.214921075364261 0.401727781752086 no 2024 0.41491442653155 2950 551469 SGTC_3199 9111318 49.47 µM -0.215211046051699 0.401619910373758 no 2025 0.414801389599424 2902 8548020 SGTC_2340 7987427 183.45 µM -0.216518956991971 0.401133450478365 no 2026 0.414291625029966 2911 2239331 SGTC_1129 3453-1384 223 µM -0.216555914049585 0.40111970702005 no 2027 0.414277222932262 3011 1084452 SGTC_1115 galangin 695.678 nM -0.21718819264677 0.400884596485018 no 2028 0.414030842990661 2811 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.217913795963145 0.400614827724539 no 2029 0.413748138910436 2799 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1385 3091-4834 14.1 µM -0.218004179459814 0.400581227772006 no 2030 0.413712927503243 2901 4072814 SGTC_3315 9136395 68.55 µM -0.218574594564603 0.400369193646758 no 2031 0.413490722437418 2832 16876844 SGTC_1849 st056239 19.2 µM -0.220779293125657 0.399549941902768 no 2032 0.41263214372189 2799 5393181 SGTC_3186 9110464 49.47 µM -0.221781147344616 0.399177805215772 no 2033 0.412242128121202 2917 17018021 SGTC_32 0928-0142 34.1 µM -0.222207203854301 0.399019575144972 no 2034 0.412076293216758 2824 2244242 SGTC_1112 tnp00069 1.16933 µM -0.223066376813323 0.398700543552826 no 2035 0.411741923232114 2900 145826 SGTC_2905 7799065 20.05 µM -0.224995475135893 0.397984469795911 no 2036 0.410991397172124 2975 1296806 SGTC_2565 isoliquiritigenin 100 µM -0.225675581228407 0.397732098845221 no 2037 0.410726875759592 2944 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1498 4478-3555 97.6 µM -0.226760148997168 0.397329730504004 no 2038 0.410305126495791 2820 3437919 SGTC_346 4513-0042 7.16 µM -0.227694947533782 0.396983013309124 no 2039 0.409941700281289 2809 2827372 SGTC_1448 4255-0083 152 µM -0.228497392438222 0.396685451059822 no 2040 0.409629791521732 2953 5399660 SGTC_2650 prasterone 100 µM -0.229726668078147 0.396229728346037 no 2041 0.409152085459778 2815 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_748 act1.228 77.9 µM -0.231162400421394 0.395697646563272 no 2042 0.408594319534555 2804 4421505 YNR035C ARC35 SGTC_205 1486-1330 71.903 µM -0.232180787524969 0.395320350487031 no 2043 0.408198799696286 2800 4118834 SGTC_2543 pimpinellin 60.67 µM -0.234457055771854 0.394477384830999 no 2044 0.407315084309392 2836 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1049 3226-0134 66 µM -0.234498321042774 0.394462107695931 no 2045 0.407299068235728 2799 5702385 SGTC_2266 7929956 200 µM -0.235404295398877 0.394126740866933 no 2046 0.406947476248188 2795 2967153 SGTC_2450 5739737 12.93 µM -0.235673702399291 0.394027028921271 no 2047 0.406842938795849 2908 2262825 SGTC_2249 haloperidol 116.36 µM -0.236189187569876 0.393836258778141 no 2048 0.406642934635322 2797 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1626 st003712 1.76 µM -0.236337691796228 0.393781305233962 no 2049 0.406585320688105 2992 24207035 SGTC_2851 9015922 71.43 µM -0.236930488904358 0.393561963523976 no 2050 0.406355358291563 3024 2996893 SGTC_2468 5987765 72.9 µM -0.236983329158101 0.393542413664045 no 2051 0.40633486166202 2874 26772094 SGTC_2602 kawain 100 µM -0.237335017106086 0.393412302844449 no 2052 0.406198449146633 2787 5369129 SGTC_3320 9137005 35.139 µM -0.238021017710976 0.393158543648367 no 2053 0.405932396412486 2871 4908713 SGTC_2972 9093619 59.92 µM -0.238413528988667 0.393013369801872 no 2054 0.405780187653058 2820 25236256 SGTC_3264 9137442 49.47 µM -0.239676279535751 0.392546431111985 no 2055 0.405290612605169 3071 17015726 SGTC_2262 9014885 67.46 µM -0.240003645072356 0.392425403410399 no 2056 0.405163715412214 2838 6457424 SGTC_3355 9151058 44.0485 µM -0.240430737320854 0.392267522183164 no 2057 0.404998175994709 2807 17015728 SGTC_999 SEC7.066 22.7 µM -0.242304059099313 0.391575229725377 no 2058 0.404272284385731 2848 740511 YDR170C SEC7 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.24249744312281 0.391503783508291 no 2059 0.404197368918501 2853 688669 SGTC_823 0417-1665 178 µM -0.243098407013225 0.391281779246519 no 2060 0.403964582613537 2938 3429856 SGTC_2350 9023895 38.85 µM -0.243188385657329 0.391248542953877 no 2061 0.403929731870245 2982 2997209 SGTC_3232 9132874 49.47 µM -0.243853884492337 0.391002745805615 no 2062 0.403671992968152 2837 3784940 SGTC_1455 4262-0120 131 µM -0.245499256446518 0.39039522671725 no 2063 0.4030349419152 3040 1529587 SGTC_2318 6029776 164 µM -0.24672071399658 0.389944402057665 no 2064 0.402562187293462 3025 818325 SGTC_832 4083-0019 164 µM -0.247461302832932 0.389671132040394 no 2065 0.40227561808947 2971 1990758 SGTC_2094 5332512 191.667 µM -0.247572184932086 0.389630222323825 no 2066 0.4022327170239 2985 755774 SGTC_811 0416-0114 265 µM -0.249316445238424 0.388986842364463 no 2067 0.401558005713862 2926 6612453 SGTC_2476 5806916 10.51 µM -0.250368038335464 0.388599103410912 no 2068 0.401151372176885 2847 2870194 SGTC_2239 6685329 187.64 µM -0.251920821409677 0.388026770809324 no 2069 0.400551132677049 2988 805680 SGTC_959 1222-0044 107 µM -0.253687657070598 0.387375837383539 no 2070 0.399868435208259 2983 6083612 SGTC_2978 9011784 42.97 µM -0.254149657304303 0.387205680474765 no 2071 0.399689970741938 2982 2994934 SGTC_1635 st007035 42.4 µM -0.254592723553437 0.387042517399402 no 2072 0.39951883990139 2879 3716403 SGTC_1927 st060202 13.8 µM -0.256324784324066 0.386404862421831 no 2073 0.39885003062094 2818 688887 SGTC_868 0527-0199 213 µM -0.256637844131951 0.386289642702106 no 2074 0.398729178895752 2884 2849450 SGTC_3214 9129694 49.47 µM -0.256755986663601 0.386246163681738 no 2075 0.398683574386262 3010 17158655 SGTC_920 mycophenolic acid 780.421 nM -0.259309847005096 0.385306637593246 no 2076 0.397698091192555 2899 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_557 1315-0110 16.2 µM -0.26044476563223 0.384889333999352 no 2077 0.397260358014261 2864 6833801 SGTC_2095 5432005 200 µM -0.261184403445813 0.384617444791115 no 2078 0.396975152521674 2877 783734 SGTC_3020 9089140 49.47 µM -0.261201783773476 0.384611056503323 no 2079 0.396968451302184 2945 17217859 SGTC_1818 st052136 56.3 µM -0.262541773280997 0.38411862637646 no 2080 0.39645189202676 2962 674169 SGTC_3351 9150312 21.596 µM -0.263134767812287 0.383900767615711 no 2081 0.39622335353465 2910 4904905 SGTC_1422 4031-0024 15.5 µM -0.263179668076873 0.383884273314294 no 2082 0.396206050545089 2925 782427 SGTC_288 1315-0019 35.1 µM -0.263864412583343 0.383632755615556 no 2083 0.395942199346858 2954 6811474 SGTC_2378 9074213 121.43 µM -0.266210510806609 0.382771368230705 no 2084 0.395038544281913 2880 657714 SGTC_2474 5321570 43.32 µM -0.266727669967766 0.382581567210006 no 2085 0.394839423964778 2996 2841384 SGTC_27 0485-0001 32.618 µM -0.268081658635287 0.382084777594393 no 2086 0.394318231778976 2853 2054479 SGTC_650 1328-0195 38 µM -0.269441749903753 0.38158594426353 no 2087 0.393794880942773 2946 2780821 SGTC_571 k831-0106 44.2 µM -0.269898222746544 0.38141857020773 no 2088 0.393619277248989 2961 4783639 SGTC_406 estrone 100 µM -0.271458620382297 0.380846589714423 no 2089 0.393019160672013 3067 5870 A steroid. SGTC_1730 st033808 45.1 µM -0.271907961609669 0.380681927082779 no 2090 0.392846394663904 2875 1045166 SGTC_3131 9127911 49.47 µM -0.273033126659839 0.380269701369216 no 2091 0.392413875630017 3127 45595681 SGTC_2423 st077119 87.2 µM -0.273547568657377 0.380081270975388 no 2092 0.392216165797622 2857 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1744 st037937 38.9 µM -0.275536895266184 0.379352886380192 no 2093 0.391451892023029 3084 1016152 SGTC_128 0906-2981 13.371 µM -0.27611689332661 0.379140602706861 no 2094 0.391229142934269 3062 6740226 SGTC_425 3825-7017 13.1 µM -0.277107333795755 0.378778178291057 no 2095 0.39084884535071 3140 3397440 SGTC_1101 ebselen 5.29 µM -0.278575221783958 0.378241241192703 no 2096 0.390285415182857 3059 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_775 4577-0580 57.3 µM -0.278746184330303 0.378178720257656 no 2097 0.390219808335087 3077 2006902 SGTC_1670 st016595 4.04 µM -0.279121668994113 0.378041416864037 no 2098 0.390075727136176 2942 597879 SGTC_2048 5246248 200 µM -0.280021180075964 0.377712555523935 no 2099 0.389730627657887 3023 677046 SGTC_2985 9022375 71.43 µM -0.280656894513887 0.377480191694955 no 2100 0.389486786766309 3096 4939335 SGTC_2397 5161689 200 µM -0.281439600366644 0.377194161057422 no 2101 0.389186624161747 3112 2259942 SGTC_2144 5628481 200 µM -0.282970137787166 0.376635038963051 no 2102 0.388599864212659 2908 2818399 SGTC_2850 9015429 58.44 µM -0.283577627415106 0.376413187992756 no 2103 0.388367042143982 2962 6457570 SGTC_33 0986-0033 35.816 µM -0.284676079824651 0.376012144522492 no 2104 0.387946159115133 2906 2848082 SGTC_751 0833-0568 350 µM -0.285445816425644 0.375731194487184 no 2105 0.387651305223297 2988 6954252 SGTC_2129 girgensonine 121.053 µM -0.286119161189266 0.375485481002813 no 2106 0.387393428124222 2980 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_155 k072-0202 43.6 µM -0.286862570500985 0.375214258584126 no 2107 0.387108775458236 2861 5857737 SGTC_3162 9099653 49.47 µM -0.287044938670907 0.375147733541927 no 2108 0.387038955647405 3012 25237511 SGTC_589 1227-0070 34.1 µM -0.287970866668049 0.374810026892591 no 2109 0.386684519747347 3036 2841384 SGTC_2150 5556613 200 µM -0.288113687903462 0.374757945331092 no 2110 0.386629857623492 2946 743190 SGTC_1097 itavastatin 7.23 µM -0.289105217250228 0.374396434697205 no 2111 0.386250430605624 2953 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2145 5634607 200 µM -0.291245177848178 0.373616583760568 no 2112 0.385431906239925 2919 308662 SGTC_3076 9116187 49.47 µM -0.292337627129313 0.373218669285898 no 2113 0.385014246195272 3025 27241210 SGTC_1261 0712-0010 12.7 µM -0.292773035134981 0.373060113626703 no 2114 0.384847820208909 3101 2840123 SGTC_579 4491-1009 110 µM -0.294776280668424 0.37233090068731 no 2115 0.384082393513424 3043 1271041 SGTC_497 capsazepine 133 µM -0.295636258725674 0.372017995329547 no 2116 0.383753940122952 2935 2733484 A calcium channel blocker. SGTC_1341 1486-1360 280 µM -0.296575859289855 0.3716762157086 no 2117 0.383395171783074 2903 3976547 SGTC_3049 9092223 49.47 µM -0.296635941565894 0.371654364223177 no 2118 0.38337223392293 3023 8623917 SGTC_1485 3909-9022 254 µM -0.296708829345094 0.371627856024821 no 2119 0.383344407801438 2964 714516 SGTC_556 4058-0063 51.5 µM -0.297723272640599 0.371258981369558 no 2120 0.382957189739883 2986 6615692 SGTC_368 fentichlor 4.58 µM -0.298473474335216 0.370986266995512 no 2121 0.382670909204839 3006 7329 A pesticide. SGTC_1876 myriocin 605 nM -0.299034308348296 0.370782434137675 no 2122 0.382456934138469 3105 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2180 6301957 200 µM -0.300154079735408 0.370375566267965 no 2123 0.382029815035719 3059 845462 SGTC_1154 4088-0362 150 µM -0.300563228883777 0.370226938451822 no 2124 0.381873787335757 2915 6618304 SGTC_2823 7987624 58.44 µM -0.300711631077599 0.370173034550244 no 2125 0.381817199381084 3165 2239440 SGTC_2545 solidagenone 89.61 µM -0.301437999461595 0.369909233675629 no 2126 0.381540260807186 2857 6708572 An anti ulcer agent SGTC_2017 5132927 60.65 µM -0.302755431350565 0.369430927895814 no 2127 0.381038125424353 2948 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2798 7813637 45.45 µM -0.304180064504873 0.368913929061073 no 2128 0.380495355956522 3077 956368 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.30562395458324 0.368390183809243 no 2129 0.37994548976316 3122 94937 An inhibitor of serotonin biosynthesis. SGTC_1026 k007-1105 30.6 µM -0.306665516534273 0.368012527580624 no 2130 0.379548989831897 2941 7066794 SGTC_3306 9127676 59.7925 µM -0.307392328444707 0.367749070969007 no 2131 0.379272383367156 3028 41905287 SGTC_2880 9042983 58.44 µM -0.309627355809645 0.366939302917161 no 2132 0.378422175501078 3080 6464714 SGTC_1669 st015249 58.4 µM -0.31153039620209 0.366250282555387 no 2133 0.377698719446574 3051 722793 SGTC_1355 1499-0035 1.68 µM -0.311687336041439 0.366193479666159 no 2134 0.37763907661502 2953 1548538 SGTC_2462 5162487 171.77 µM -0.312207219306639 0.366005333789444 no 2135 0.377441522963448 2922 2259986 SGTC_3137 9097352 49.47 µM -0.312225410261955 0.365998751061515 no 2136 0.37743461105032 3250 44120435 SGTC_224 benfluorex 43.875 µM -0.312498402519248 0.36589996858833 no 2137 0.377330888461825 3059 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2825 7998094 58.44 µM -0.313070096457794 0.3656931294734 no 2138 0.37711370374157 3011 2987815 SGTC_105 0111-0055 734.78 µM -0.313204560843921 0.365644485869214 no 2139 0.377062626790011 3048 5179370 SGTC_320 4092-0846 5.34 µM -0.314517374917787 0.365169678142169 no 2140 0.376564061123621 3050 1359356 SGTC_1787 fluconazole 80 µM -0.314919376366376 0.36502432687419 no 2141 0.376411434690102 3045 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2111 5486399 200 µM -0.315006342114202 0.364992885305022 no 2142 0.376378419260921 2969 689674 SGTC_3245 9134821 49.47 µM -0.315770326699753 0.364716713593058 no 2143 0.376088421223008 2964 17014901 SGTC_142 0335-0849 62.6745 µM -0.316044979413998 0.364617446914294 no 2144 0.375984183917492 3040 3889043 YPR107C YTH1 SGTC_1314 1222-0010 41.1 µM -0.318733202740769 0.363646332788371 no 2145 0.374964417314477 3013 3526027 SGTC_802 4112-3352 742 µM -0.320002071636552 0.363188260709049 no 2146 0.374483380063448 3112 704594 SGTC_1862 st057513 3.81 µM -0.32165669265737 0.362591222876992 no 2147 0.373856394892605 2962 5393163 SGTC_3252 9135871 49.47 µM -0.322462570291898 0.362300558443708 no 2148 0.373551144575384 3123 17682838 SGTC_1740 st038286 13.222 µM -0.323732477080727 0.361842688828323 no 2149 0.373070290337784 3190 716786 SGTC_2186 6124449 200 µM -0.324635208071582 0.361517325985774 no 2150 0.372728588527317 3119 3834182 YLR033W RSC58 SGTC_1146 3579-1023 7 µM -0.325600100810149 0.361169669459629 no 2151 0.372363467956184 3094 X1146 SGTC_1834 st055981 52.8 µM -0.325797653730849 0.361098504109781 no 2152 0.372288727009722 3121 471719 YDL150W RPC53 SGTC_1179 1021-1431 9.29 µM -0.327631105064667 0.360438261587426 no 2153 0.371595300237059 3064 2840958 SGTC_2931 9014674 55.67 µM -0.331094136899029 0.35919232831574 no 2154 0.370286690098121 2965 2996810 SGTC_3303 9125618 40.5795 µM -0.331414102086514 0.359077286198845 no 2155 0.370165857147551 3065 22695467 SGTC_3218 9131285 49.47 µM -0.3317871818509 0.358943163099026 no 2156 0.370024981973047 3167 17156417 SGTC_1117 retinoic acid 1.10837 µM -0.331854488456719 0.358918968058373 no 2157 0.36999956880873 3144 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1424 4048-1941 275 µM -0.332000995240191 0.358866304492581 no 2158 0.369944253749844 3123 X1424 SGTC_879 0831-1030 162 µM -0.332502197018544 0.358686161981259 no 2159 0.369755040503392 3005 1549252 SGTC_1227 3909-8010 46.6 µM -0.334531173544637 0.357957226494695 no 2160 0.36898938571886 2996 15982272 SGTC_246 cycloheximide 667 µM -0.33469225983359 0.357899376350633 no 2161 0.368928620404238 2971 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3195 9113082 49.47 µM -0.3352695292478 0.357692091172329 no 2162 0.368710888516193 3093 17018038 SGTC_1710 st031758 61.5 µM -0.336157985896418 0.357373147282762 no 2163 0.368375866774983 3161 5394341 SGTC_164 4100-3994 89.624 µM -0.336503523580564 0.357249130829603 no 2164 0.368245597457208 3119 4615967 SGTC_2541 muurolladie-3-one 83.07 µM -0.336861762980391 0.357120571540238 no 2165 0.368110555525099 3159 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_710 3448-4187 58 µM -0.336885816095645 0.357111940319613 no 2166 0.36810148904586 3038 3946412 SGTC_2108 5365811 200 µM -0.337159321069763 0.357013800930212 no 2167 0.367998400409355 3105 780283 SGTC_1713 st033146 12.748 µM -0.337266242472586 0.356975437833422 no 2168 0.367958102513814 3152 674619 SGTC_2954 9074818 52.69 µM -0.338959887130853 0.356367956034631 no 2169 0.367319974298906 3166 16648742 SGTC_35 0133-0054 64.071 µM -0.339372121001421 0.356220149757609 no 2170 0.367164708961643 3043 99677 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.339422626175629 0.35620204263396 no 2171 0.36714568799328 3013 4174840 SGTC_2935 9038016 29.96 µM -0.339461278886844 0.356188185076394 no 2172 0.367131131051653 3173 6463195 SGTC_261 5-fluorouridine 15.376 µM -0.339538493432913 0.356160503110461 no 2173 0.367102051965117 3216 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_736 0958-0254 92.6 µM -0.34204353876045 0.355262838478575 no 2174 0.366159063466899 3113 6812352 SGTC_872 0588-0139 234 µM -0.342742223975462 0.355012612669964 no 2175 0.365896197226579 3009 2047100 SGTC_2641 levomentholum 100 µM -0.343014992825015 0.354914940709734 no 2176 0.365793590517052 3063 16666 SGTC_608 k048-0125 159 µM -0.344240334061555 0.354476293204615 no 2177 0.365332775789037 3125 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_817 1391-0715 46 µM -0.344467122036508 0.354395128815919 no 2178 0.365247508809494 3051 1353946 SGTC_2876 9059903 25.97 µM -0.344948153552574 0.35422299594821 no 2179 0.365066674251245 2998 6916095 SGTC_294 k038-0071 157 µM -0.34573141090955 0.353942777975923 no 2180 0.364772287911824 3068 24152826 SGTC_3237 9133362 49.47 µM -0.346152663777751 0.353792103344812 no 2181 0.364613993477993 3110 43845137 SGTC_1618 st003135 44.5 µM -0.348321099147514 0.35301685550104 no 2182 0.363799524999151 3095 1270615 SGTC_394 menadione 8.33 µM -0.350916033635436 0.352089929445927 no 2183 0.362825671189792 3148 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2283 7944793 200 µM -0.353965935909195 0.35100160896198 no 2184 0.361682205931402 3105 2970533 SGTC_1372 2752-0194 270 µM -0.354338694098792 0.350868678307227 no 2185 0.361542536356353 3012 823334 SGTC_2109 5483026 200 µM -0.354594061540692 0.350777621328276 no 2186 0.361446862821775 3072 759335 SGTC_2497 7-hydroxyflavone 100 µM -0.354672882761968 0.350749517587818 no 2187 0.361417334162785 3181 5281894 SGTC_1810 st050138 53 µM -0.35535099555913 0.35050776992737 no 2188 0.361163328044827 3162 3444541 SGTC_1753 st043925 64 µM -0.355653561536305 0.350399924481388 no 2189 0.361050013233232 3135 670181 SGTC_2705 st078069 42.8 µM -0.356386036724229 0.350138893808469 no 2190 0.360775742453452 3101 1530061 SGTC_2395 5646831 180.19 µM -0.357220638763159 0.34984155468163 no 2191 0.36046331817161 3203 6808628 SGTC_730 1436-0052 41.2 µM -0.357673952465105 0.349680093646332 no 2192 0.360293664088405 3027 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1195 1502-0147 41.1 µM -0.357983001688359 0.349570032239912 no 2193 0.360178017207684 3045 817940 SGTC_1174 0739-0097 51.1 µM -0.358885171851425 0.349248815593539 no 2194 0.359840496422861 3061 728447 SGTC_1676 st018489 23.4 µM -0.359739917384205 0.348944584016169 no 2195 0.359520818982009 3031 3696235 SGTC_157 1348-1695 65.819 µM -0.360405029953189 0.34870791609227 no 2196 0.359272132831778 3063 5380510 SGTC_477 mead ethanolamide 10 µM -0.36152658149693 0.348308966211975 no 2197 0.358852918811692 3063 16061185 SGTC_3139 9095020 49.47 µM -0.369613188536498 0.345437448764183 no 2198 0.355835361469223 2945 25236292 SGTC_411 enrofloxacin 100 µM -0.370103245823683 0.345263715170356 no 2199 0.355652781876101 3224 71188 A bacterial gyrase inhibitor. SGTC_3117 9124945 49.47 µM -0.370294098146616 0.345196063613847 no 2200 0.355581685391843 2991 17592065 SGTC_2490 carminic acid 95.39 µM -0.370350227263017 0.345176168427883 no 2201 0.355560777077372 3027 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1745 st081495 74 µM -0.371862369489476 0.344640344872312 no 2202 0.354997661970622 3091 13842402 YBL026W LSM2 SGTC_2225 6654152 15.4 µM -0.373216706429007 0.344160703613456 no 2203 0.35449358155138 3119 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2429 5902844 64.44 µM -0.373450708972441 0.344077856491104 no 2204 0.354406512245498 3182 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1113 artemisinin 1.17947 µM -0.374680653159192 0.34364252564661 no 2205 0.353948991185509 3166 2240 An anti-malaria and mitochondrial poison. SGTC_319 1348-1596 45.5 µM -0.375683083800708 0.34328787503625 no 2206 0.35357625768633 3236 5380505 SGTC_2342 7990637 118.86 µM -0.377325302292286 0.342707171697457 no 2207 0.352965935487746 3172 2033102 YER133W GLC7 SGTC_739 1486-1183 203 µM -0.379220051804032 0.342037632700058 no 2208 0.352262231247558 3202 4346692 SGTC_1076 itraconazole 331 nM -0.379680213930314 0.341875102143572 no 2209 0.352091404625953 3125 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_933 2914-0560 114 µM -0.382901306141071 0.340738225214092 no 2210 0.35089647143888 3244 463887 SGTC_3314 9135860 59.4275 µM -0.383166054312827 0.340644847100985 no 2211 0.350798322791143 3214 25252478 SGTC_94 0334-0113 514.748 µM -0.383877435065151 0.340393987646555 no 2212 0.350534645812671 3105 6795178 SGTC_2659 sanguinarine 24.21 µM -0.385250759287565 0.339909901974078 no 2213 0.35002581979458 3056 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1846 st056244 14.8 µM -0.385523280856688 0.339813871676524 no 2214 0.349924880665755 3122 5393182 SGTC_286 k060-0067 22.9 µM -0.385967961359352 0.33965719887407 no 2215 0.349760198446918 3109 5985051 SGTC_80 0159-0065 512.242 µM -0.386017396615392 0.339639783225179 no 2216 0.349741892423627 3166 1548079 SGTC_1286 0929-0070 131 µM -0.387045008724669 0.339277841200528 no 2217 0.349361443743546 3186 1420408 SGTC_372 0155-0182 15.9 µM -0.387481645089982 0.339124095488816 no 2218 0.349199835404047 3041 771486 SGTC_458 nppb 133 µM -0.387774943928963 0.339020835942798 no 2219 0.349091294658888 3274 4549 A chloride channel blocker. SGTC_1945 st075991 56.6 µM -0.38974670728592 0.338326966089197 no 2220 0.348361927417283 3113 1084980 SGTC_1506 4226-2149 212 µM -0.390978105482156 0.337893911257747 no 2221 0.347906709812565 3187 991114 SGTC_2586 curcumin 80 µM -0.391060165680362 0.337865060162632 no 2222 0.34787638195788 3191 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1410 3909-8106 77.9 µM -0.393734913906977 0.336925182478222 no 2223 0.346888380835271 3194 1039210 SGTC_304 1310-0298 97 µM -0.395163450128587 0.336423626606948 no 2224 0.34636113237759 3155 1550234 SGTC_254 nsc-64875 3.808 µM -0.396272653890842 0.336034388239988 no 2225 0.345951949274444 3256 56993 SGTC_2994 9053520 71.4286 µM -0.396797465919967 0.335850284046834 no 2226 0.345758409781611 3205 4647384 SGTC_1662 st014054 52 µM -0.396964110056021 0.33579183347774 no 2227 0.345696963402948 3133 2838777 SGTC_2722 naftopidil 47.16 µM -0.397410525316187 0.335635272530326 no 2228 0.345532377576976 3214 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_678 1218-2179 85.9 µM -0.399301006447627 0.334972584094936 no 2229 0.344835712812435 3170 6820081 YOR116C RPO31 SGTC_2021 4019055 173 µM -0.402159723288741 0.333971466471486 no 2230 0.343783240862313 3269 44827708 YER133W GLC7 SGTC_3200 9114385 49.47 µM -0.40280988580902 0.333743945198792 no 2231 0.343544044023596 3240 17018030 YLR208W SEC13 SGTC_204 PMA1.184 62.41 µM -0.403072609974265 0.333652023464249 no 2232 0.34344740474008 3134 2252213 YGL008C PMA1 SGTC_3013 9080133 71.4286 µM -0.403259642643052 0.333586590697566 no 2233 0.34337861371384 3330 17050193 SGTC_1754 st042065 16.137 µM -0.403619272740714 0.33346078951083 no 2234 0.343246355555054 3203 1126236 YIL048W NEO1 SGTC_3050 9093513 49.47 µM -0.404155470146004 0.333273258592967 no 2235 0.343049198363135 3130 25236664 SGTC_2281 7943571 200 µM -0.404754426482016 0.333063827495242 no 2236 0.34282901553189 3334 1244024 SGTC_2444 5485484 36.41 µM -0.405368434101056 0.332849187596395 no 2237 0.342603355087851 3224 6790631 SGTC_2396 5342950 42.78 µM -0.405630823222856 0.332757480392265 no 2238 0.342506938805672 3182 1886677 SGTC_1232 0279-0259 161 µM -0.405732668743747 0.332721887221626 no 2239 0.342469517889983 3152 1560000 SGTC_104 0074-0074 590.992 µM -0.406328501738863 0.33251368456833 no 2240 0.342250623044995 3115 3943124 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.406624833814624 0.332410156119101 no 2241 0.342141777427383 3045 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_146 3448-8650 53.125 µM -0.407418149853474 0.332133061150892 no 2242 0.341850449399614 3123 2891488 YIL048W NEO1 SGTC_1075 aripiprazole 15.2 µM -0.40790885861214 0.331961708890157 no 2243 0.34167029441891 3108 60795 An atypical antipschotic. YIL048W NEO1 SGTC_620 0109-0052 432 µM -0.40829245038551 0.331827785641625 no 2244 0.341529490639395 3270 493037 SGTC_1349 flufenamic acid 69 µM -0.408829233831243 0.331640414717325 no 2245 0.341332492315151 3102 3371 A non-steroidal anti-inflammatory. SGTC_49 0717-0965 32.132 µM -0.409554209579277 0.331387419792566 no 2246 0.341066496461917 3369 5889349 YGL099W LSG1 SGTC_696 1560-0013 611 µM -0.410029066199814 0.331221750673247 no 2247 0.340892312886759 3306 1650269 SGTC_1484 3473-2379 286 µM -0.410163438835429 0.331174876419464 no 2248 0.34084302941328 3240 671917 SGTC_4 0960-0234 25.671 µM -0.41022894067307 0.331152027861957 no 2249 0.340819006473273 3201 6821112 SGTC_808 0711-0032 135 µM -0.410581816412548 0.331028947452314 no 2250 0.340689599643982 3220 4252555 SGTC_354 2783-3500 4.88 µM -0.410750389806957 0.330970156760943 no 2251 0.340627786911419 3146 6740761 SGTC_3093 9117344 49.47 µM -0.4113246056378 0.330769927822588 no 2252 0.340417264759853 3250 24824913 SGTC_1281 0884-0031 11.8 µM -0.411430420393701 0.330733035520401 no 2253 0.340378475798042 3143 1548255 SGTC_58 0957-0393 9 µM -0.413545395557865 0.329995994941743 no 2254 0.339603535087645 3257 6997992 SGTC_1276 0871-0068 94.2 µM -0.415764490414703 0.329223378876678 no 2255 0.338791172639241 3200 3414906 SGTC_2038 4100038 30.985 µM -0.418259279970674 0.328355645164507 no 2256 0.33787877905861 3221 3596803 SGTC_2664 lyso-paf C-16 73.48 µM -0.419948256502587 0.327768712877854 no 2257 0.337261627021768 3131 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2837 9008476 45.46 µM -0.420845034108709 0.327457248520473 no 2258 0.336934122235315 3294 2992805 SGTC_1402 3909-7673 35.9 µM -0.421389285101594 0.327268280487613 no 2259 0.336735421043021 3149 5328014 SGTC_108 0509-0257 621.132 µM -0.421400017165322 0.327264554679318 no 2260 0.336731503320045 3169 536624 SGTC_2029 5175081 200 µM -0.421573142158472 0.327204453935615 no 2261 0.33666830676223 3147 1380876 SGTC_1646 st011709 75.6 µM -0.421977973041407 0.32706393344186 no 2262 0.33652054761603 3242 5757843 SGTC_1624 st003710 6.25 µM -0.422436093799979 0.326904945112281 no 2263 0.336353368651177 3252 24207033 SGTC_1278 0874-0585 172 µM -0.423013138912017 0.326704729439854 no 2264 0.336142837453003 3205 766306 SGTC_529 4076-0302 30.3 µM -0.424801983822601 0.326084376387145 no 2265 0.335490515693532 3156 5816522 SGTC_1370 2001-0092 44.6 µM -0.426137865003012 0.325621420109551 no 2266 0.335003695184305 3370 790957 SGTC_317 4495-0002 170 µM -0.427197034969228 0.325254550514976 no 2267 0.334617910384034 3193 15991618 SGTC_1298 1079-1278 263 µM -0.428801253044911 0.324699212570172 no 2268 0.334033933451965 3217 2840950 SGTC_2024 5144227 134 µM -0.429576238223629 0.324431072596069 no 2269 0.333751962555489 3278 3475211 SGTC_2113 5491891 107.031 µM -0.430787943879604 0.324012012504877 no 2270 0.333311283264205 3208 789979 SGTC_948 3448-0295 75.3 µM -0.432214563546206 0.323518911621945 no 2271 0.332792737758892 3199 678569 SGTC_1150 3909-7983 10.9 µM -0.432943470337224 0.323267089706603 no 2272 0.332527919172739 3179 23965914 SGTC_1788 fluconazole 20 µM -0.433168350641016 0.323189414642273 no 2273 0.332446234936874 3249 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1892 st058411 7.36 µM -0.433333949147598 0.323132220809449 no 2274 0.332386088968732 3267 3934738 SGTC_1008 4106-0037 6 µM -0.434762907332226 0.322638866046721 no 2275 0.331867265704288 3086 2905394 SGTC_673 1082-0474 110 µM -0.435228957080913 0.32247802755177 no 2276 0.331698122940543 3186 3098046 SGTC_746 1095-0025 46.6 µM -0.43612860063679 0.322167645411171 no 2277 0.331371713653332 3324 6749286 SGTC_2456 5770359 74.46 µM -0.436523144371199 0.322031564673023 no 2278 0.331228605405387 3311 3118787 SGTC_954 1189-0853 2.85 µM -0.438869968081218 0.321222623218564 no 2279 0.330377879302315 3242 2828194 SGTC_3060 1327-0027 12.5 µM -0.440293689178308 0.320732284564978 no 2280 0.329862205437549 3209 16000455 YPR107C YTH1 SGTC_1032 k061-1018 98.7 µM -0.440576076450063 0.320635065706206 no 2281 0.329759962731895 3356 4005393 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.441627513342384 0.320273190567626 no 2282 0.329379385546419 3211 688664 SGTC_1430 4049-0248 69.1 µM -0.442501551917168 0.319972500989969 no 2283 0.329063153766249 3276 22774488 SGTC_2519 cryptotanshinone 88.04 µM -0.443708950502866 0.319557322318188 no 2284 0.328626511747136 3318 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_843 0310-0051 143 µM -0.44371083632524 0.319556674031943 no 2285 0.328625829943625 3222 2065037 SGTC_1556 plumbagin 1.48 µM -0.443813552105935 0.319521364419679 no 2286 0.328588694762921 3258 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_596 1155-0152 116 µM -0.443915164444609 0.319486435736948 no 2287 0.32855196017896 3216 280313 SGTC_2208 7283366 200 µM -0.444304412956139 0.319352648521457 no 2288 0.32841125557347 3282 898663 SGTC_2888 9058547 12.99 µM -0.444543766554457 0.319270392826039 no 2289 0.328324746696852 3152 16476514 SGTC_1910 st062352 60.4 µM -0.446995008138482 0.31842851750459 no 2290 0.32743933207284 3138 2245730 SGTC_353 1988-1175 58.3 µM -0.447534256428512 0.318243439022907 no 2291 0.32724467980094 3086 2788357 SGTC_2161 5662504 8.5105 µM -0.448193733409839 0.318017157832396 no 2292 0.32700669246982 3191 2859334 SGTC_471 1-acyl-paf 4 µM -0.449037282595339 0.317727816391023 no 2293 0.326702381009457 3183 16759367 SGTC_252 miconazole 1.30953 nM -0.449528170758021 0.317559490589358 no 2294 0.326525345505142 3251 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_658 3253-0951 102 µM -0.449556180947283 0.317549887018148 no 2295 0.326515244997047 3232 1184878 SGTC_965 1291-5240 308 µM -0.449779570745662 0.317473300005037 no 2296 0.326434694918385 3313 2834598 SGTC_1794 st048918 76.9 µM -0.449930705738418 0.317421489277782 no 2297 0.326380203127055 3253 672303 SGTC_136 0097-0015 404.482 µM -0.451427769272547 0.316908472864578 no 2298 0.325840636470621 3299 4861337 SGTC_1936 st074407 74.3 µM -0.451479665253135 0.316890695360808 no 2299 0.325821938825639 3172 809813 SGTC_1706 st031321 9.9705 µM -0.454371439854826 0.315900757216008 no 2300 0.324780752485753 3301 6103185 SGTC_2804 7954240 19.48 µM -0.455560213367555 0.315494187735818 no 2301 0.324353129530588 3297 828705 SGTC_285 1486-1325 46 µM -0.456534057035285 0.31516129220465 no 2302 0.324002993153965 3313 22310230 SGTC_649 1123-0311 367 µM -0.456607332197253 0.315136250129726 no 2303 0.323976654047726 3271 693629 YIL048W NEO1 SGTC_1978 st071761 42 µM -0.457566323320494 0.314808589490382 no 2304 0.323632021396395 3189 5147680 SGTC_662 k832-1615 104 µM -0.458114637452378 0.314621311242164 no 2305 0.323435041660449 3279 5878478 SGTC_2854 9024559 71.43 µM -0.458127467046864 0.314616929828451 no 2306 0.323430433270293 3281 3163529 SGTC_793 0488-0545 106 µM -0.458418849958846 0.31451742715934 no 2307 0.323325775827096 3188 292548 SGTC_1098 clofazimine 15.1 µM -0.459283286224981 0.31422231509248 no 2308 0.323015374249769 3323 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_273 hydroxyurea 18.1 mM -0.459832606936271 0.314034842796174 no 2309 0.322818188308426 3187 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_481 bay k-8644 50 µM -0.461486627640742 0.313470648133615 no 2310 0.322224756607581 3228 2303 A calcium channel antagonist. SGTC_1203 3992-3522 103 µM -0.461514172427172 0.313461256159018 no 2311 0.322214877882781 3498 5322312 SGTC_183 3914-0051 30.55 µM -0.462918887850702 0.312982449344675 no 2312 0.32171125418516 3336 1596232 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.464552179630802 0.312426127098513 no 2313 0.321126092138758 3232 2333 A French combination drug. SGTC_1258 0671-0043 57.1 µM -0.464909568535433 0.312304452319599 no 2314 0.320998108987108 3253 4298767 SGTC_2200 6600604 21.907 µM -0.465670467639444 0.312045468726086 no 2315 0.320725697208605 3218 2904777 SGTC_3179 9107801 49.47 µM -0.465968604481943 0.31194401863059 no 2316 0.320618986648024 3221 4818259 SGTC_1663 st014140 55.4 µM -0.466780965051377 0.311667660733161 no 2317 0.320328297923939 3316 4207120 SGTC_2387 9077560 195.08 µM -0.466781121635828 0.311667607474729 no 2318 0.320328241903608 3211 5303272 SGTC_610 4215-0184 155 µM -0.46712147024574 0.311551855399896 no 2319 0.320206486989647 3282 5605015 SGTC_603 3794-0023 45.9 µM -0.469279165945302 0.310818459805502 no 2320 0.319435052564301 3309 3802260 SGTC_1173 0443-0020 122 µM -0.4723262677692 0.309784036578154 no 2321 0.318346961891668 3227 5331295 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.472549207804116 0.309708412366106 no 2322 0.318267413495703 3329 5024745 SGTC_1062 mesoridazine 14.2 µM -0.475256812691789 0.308790600596574 no 2323 0.317301968706913 3295 4078 A neuroleptic. SGTC_2815 7968870 71.43 µM -0.477405613523673 0.308063058320461 no 2324 0.316536658830761 3249 2977326 YHR190W ERG9 SGTC_1558 st069300 45.6 µM -0.478037063956748 0.307849404593739 no 2325 0.316311912563869 3322 24208000 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.478145312156825 0.307812784928896 no 2326 0.316273391599828 3266 16623 A steroid. SGTC_2651 TUB2.036 5 µM -0.479546287309134 0.307339016919677 no 2327 0.315775023697335 3406 15992207 YFL037W TUB2 SGTC_495 decylubiquinone 155 µM -0.479950830749586 0.307202272145654 no 2328 0.315631177990431 3302 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1090 efavirenz 20.7 µM -0.480156152505774 0.307132879031228 no 2329 0.315558181301785 3294 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2367 9070478 135.38 µM -0.483696381240793 0.30593746686602 no 2330 0.314300680900653 3301 572802 SGTC_859 0439-0102 54.6 µM -0.485859804130062 0.305207969369338 no 2331 0.313533284616707 3363 610143 SGTC_1743 st037606 46.3785 µM -0.48613823171269 0.305114140801008 no 2332 0.313434580965306 3253 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_684 1140-0066 328 µM -0.488810699497243 0.304214186006022 no 2333 0.312487861181072 3326 6813534 SGTC_734 2023-0417 80 µM -0.489297730107491 0.304050305677226 no 2334 0.312315463928354 3329 3935732 SGTC_2496 diffractaic acid 79.83 µM -0.489782541596128 0.303887211151054 no 2335 0.312143892989417 3457 94870 An apoptosis inducer which activates caspases. SGTC_217 ketoconazole 989 nM -0.489915505361618 0.303842487878318 no 2336 0.312096845284531 3322 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_967 1306-0166 352 µM -0.490380527493885 0.303686097596627 no 2337 0.311932326637158 3369 4437607 SGTC_2125 5246583 200 µM -0.490840967259776 0.303531283806492 no 2338 0.311769466129534 3422 835267 SGTC_3024 9090631 49.47 µM -0.49115189195611 0.303426761450402 no 2339 0.311659510879441 3359 25236383 SGTC_3108 9121785 49.47 µM -0.49264578723791 0.302924788839149 no 2340 0.311131444796563 3349 17140271 SGTC_2638 epoxomicin 18 µM -0.492689017807086 0.302910268214621 no 2341 0.311116169319338 3344 9915668 A protesome inhibitor. SGTC_875 0709-0210 25.7 µM -0.492842914215165 0.302858578804348 no 2342 0.311061792822413 3378 6251364 SGTC_2248 tofa 1.1 µM -0.494370251187682 0.302345804146797 no 2343 0.310522359804525 3189 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_72 0744-0168 198.391 µM -0.494719201061258 0.302228705465197 no 2344 0.310399172930545 3170 677577 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.494754264158572 0.302216940308987 no 2345 0.310386796072177 3328 5355888 SGTC_2855 9016525 58.44 µM -0.496013213130254 0.301794645795226 no 2346 0.309942544327133 3315 43811474 SGTC_11 0438-0307 1.3 µM -0.49640017979492 0.301664897262843 no 2347 0.309806049124182 3373 4011476 SGTC_2951 9072950 58.06 µM -0.499538706891624 0.300613488581494 no 2348 0.308699962759713 3371 16488155 SGTC_2279 7948423 32.93 µM -0.500611143445166 0.300254601223166 no 2349 0.308322409193082 3422 1247112 SGTC_2767 sibutramine 71.45 µM -0.501538236869031 0.29994450864448 no 2350 0.307996187281954 3450 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1719 st032227 49.2 µM -0.501786006819142 0.299861659536699 no 2351 0.3079090286584 3275 3125804 SGTC_3197 9113331 49.47 µM -0.502015204662154 0.299785029779732 no 2352 0.307828412836641 3453 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1524 corynanthine 62.1 µM -0.502070505056612 0.299766542034107 no 2353 0.307808963402158 3397 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1012 4112-3522 18 µM -0.504131605655887 0.299077853978025 no 2354 0.307084449181906 3400 3112398 SGTC_2744 captopril 92.04 µM -0.505374475960021 0.298662913662153 no 2355 0.306647921257011 3338 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3044 9093193 49.47 µM -0.505802353631435 0.298520124517078 no 2356 0.306497703045738 3354 25236277 SGTC_2057 5236571 38.335 µM -0.50612065959999 0.298413921228473 no 2357 0.306385974075943 3439 54684039 YBR257W POP4 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.509011647400838 0.297450126915534 no 2358 0.305372030000217 3261 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1414 3917-0015 5.4 µM -0.510296800230535 0.297022140995573 no 2359 0.304921772056951 3370 6618702 SGTC_327 1273-0057 3.96 µM -0.511146146165467 0.296739443630063 no 2360 0.304624362610212 3333 3108138 SGTC_2584 androsterone 48.74 µM -0.511752186299536 0.29653780381366 no 2361 0.304412228739206 3390 2754130 A steroid. SGTC_1490 4089-0339 670 nM -0.51275662374216 0.296203748787097 no 2362 0.304060787666056 3382 742542 SGTC_2795 7780010 54.55 µM -0.513204305080078 0.296054914911841 no 2363 0.303904207415408 3393 953673 SGTC_1798 st045719 60.953 µM -0.514169635223412 0.295734102990365 no 2364 0.30356669764919 3351 3980186 SGTC_2289 7946404 165.07 µM -0.515658155545981 0.295239730557421 no 2365 0.303046592462853 3302 1246120 YPR165W RHO1 SGTC_2311 7694451 200 µM -0.515956445192758 0.295140707357636 no 2366 0.302942414787114 3301 2163142 SGTC_1053 3366-3204 134 µM -0.515959907664317 0.295139558010913 no 2367 0.302941205612845 3317 3632071 YPR165W RHO1 SGTC_3148 9097893 49.47 µM -0.517216426955456 0.294722600103847 no 2368 0.302502543052962 3257 17174100 SGTC_195 4234-0266 16.654 µM -0.517666992720145 0.294573152511944 no 2369 0.302345315750137 3309 2303354 SGTC_113 0099-0221 2.5 µM -0.518880632007134 0.294170776061672 no 2370 0.301921992382539 3461 89219 SGTC_3216 9129716 49.47 µM -0.520226057390575 0.29372500360125 no 2371 0.301453012869634 3306 8056934 SGTC_1322 1348-1070 12 µM -0.522102718217639 0.293103742463352 no 2372 0.300799407001863 3408 6758089 SGTC_1468 k284-1086 134 µM -0.522435532932246 0.2929936291251 no 2373 0.30068356063772 3365 15996457 SGTC_3052 9092717 49.47 µM -0.524033369627843 0.292465244685513 no 2374 0.300127665223771 3427 25237534 SGTC_3081 9117243 49.47 µM -0.524997889317098 0.292146504726597 no 2375 0.299792329107155 3448 45595589 SGTC_2380 9035439 200 µM -0.525111916651018 0.292108833375921 no 2376 0.299752696256684 3460 6462575 SGTC_1409 3909-8004 61.9 µM -0.526999559322137 0.291485539294557 no 2377 0.29909694724913 3358 2119279 SGTC_646 4092-0839 27.3 µM -0.528757670543888 0.290905574661408 no 2378 0.298486782622696 3470 877796 SGTC_993 3909-8757 62.7 µM -0.528837547824582 0.290879237606794 no 2379 0.298459074115739 3303 4288324 YLR208W SEC13 SGTC_856 0433-0016 11.3 µM -0.529759414337221 0.290575361415988 no 2380 0.298139373995193 3391 3911780 SGTC_1017 4239-0030 168 µM -0.530856705386487 0.290213853526031 no 2381 0.297759040742005 3327 1149593 SGTC_277 nystatin 15.5 µM -0.53119694941516 0.290101801282129 no 2382 0.297641153356437 3281 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_980 1473-0395 201 µM -0.531412346054484 0.290030875393479 no 2383 0.29756653397236 3332 768876 SGTC_1841 st054148 70 µM -0.531417749164406 0.290029096359871 no 2384 0.297564662294669 3374 675442 SGTC_2453 5731132 22.18 µM -0.533476268756042 0.289351678601561 no 2385 0.296851967129822 3449 1362040 SGTC_2592 piperlongumine 83.33 µM -0.534102334546227 0.28914580036831 no 2386 0.296635367330611 3347 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_525 k781-2675 26.7 µM -0.536169187457673 0.288466616856702 no 2387 0.295920813313943 3453 3651118 YDL195W SEC31 SGTC_1027 k015-0025 8.67 µM -0.537197511394851 0.288128982166242 no 2388 0.295565595046996 3392 3598955 SGTC_3007 9078383 71.4286 µM -0.537884356038058 0.287903570979573 no 2389 0.295328444667211 3329 6496995 SGTC_687 k029-0044 34.9 µM -0.539297155058326 0.287440175417445 no 2390 0.294840915780656 3438 5829338 SGTC_583 1488-1091 88.9 µM -0.542006398459742 0.286552536579904 no 2391 0.293907049027268 3461 4303273 SGTC_2738 aclarubicin 5.55 µM -0.54231450709758 0.286451672280301 no 2392 0.293800931744171 3335 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1051 3253-3903 78 µM -0.542407602170634 0.28642119943109 no 2393 0.29376887187804 3330 5509239 SGTC_532 1548-0774 215 µM -0.543971495620248 0.285909519681273 no 2394 0.293230544037351 3546 5932993 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.544464672773539 0.285748250551142 no 2395 0.293060876095295 3373 5379071 SGTC_522 1273-0010 11.6 µM -0.54528504651335 0.285480083895579 no 2396 0.292778743499744 3497 5705015 SGTC_581 0958-0271 211 µM -0.546342524868963 0.285134588517464 no 2397 0.292415255045778 3375 4591145 SGTC_1491 4138-0063 26.5 µM -0.546693348865397 0.285020012654654 no 2398 0.292294712206964 3418 23883227 SGTC_611 3453-1652 23.7 µM -0.54694351315312 0.284938324729799 no 2399 0.292208770080671 3460 1560575 SGTC_363 0455-0021 3.06 µM -0.547111588704156 0.284883448096463 no 2400 0.292151035547936 3433 4597466 SGTC_1020 4335-0961 93.3 µM -0.547624901142232 0.284715882908852 no 2401 0.291974743821009 3277 669075 SGTC_2634 4'-methoxyflavone 100 µM -0.548307888827707 0.284493002073921 no 2402 0.291740255754492 3378 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_569 4130-2812 160 µM -0.548583112988908 0.284403211148505 no 2403 0.2916457887015 3388 743552 SGTC_2802 7925815 54.55 µM -0.55350632476429 0.282799322384 no 2404 0.2899583754434 3361 1262923 SGTC_315 k915-0449 187 µM -0.554735246221388 0.28239964185836 no 2405 0.289537882078472 3430 20970215 YNL149C PGA2 SGTC_2064 5220758 200 µM -0.555354209529998 0.282198440165487 no 2406 0.289326203258358 3504 788518 SGTC_1702 st027038 51 µM -0.555746930843726 0.282070817023622 no 2407 0.289191934496161 3443 5521182 SGTC_2390 9097792 176.6 µM -0.556608683948031 0.281790869469615 no 2408 0.288897409647167 3366 4497149 SGTC_3030 9087619 49.47 µM -0.556881459086712 0.281702284142134 no 2409 0.288804211604944 3401 25236973 SGTC_1998 st075797 76.8 µM -0.557260314855918 0.281579270784645 no 2410 0.288674792883225 3475 24208315 SGTC_1283 0922-0125 16.4 µM -0.557299639579422 0.281566503646549 no 2411 0.288661360957392 3424 3360884 SGTC_523 1934-0222 13.7 µM -0.558965360781956 0.281025968279752 no 2412 0.28809268037685 3369 1361595 SGTC_907 3448-6986 75.5 µM -0.558993480430119 0.281016847609957 no 2413 0.288083084811727 3518 590582 SGTC_3202 9113761 49.47 µM -0.561370876456118 0.280246251664718 no 2414 0.287272366767249 3459 4798415 SGTC_2685 mycophenolic acid 18.85 µM -0.56348005496665 0.279563452288916 no 2415 0.286554018892462 3400 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_587 k089-0003 57 µM -0.567249336025125 0.278345246943055 no 2416 0.28527239655417 3445 9659696 SGTC_1903 st060211 78.3 µM -0.568458470228133 0.277955012045762 no 2417 0.284861848803367 3510 688960 SGTC_3356 9151811 4.48 µM -0.57039282658674 0.277331275374168 no 2418 0.284205646916591 3390 1859254 YPR165W RHO1 SGTC_2793 7325131 81.82 µM -0.570474308504696 0.277305016414108 no 2419 0.2841780212478 3397 4176441 SGTC_266 formosanin C 406 nM -0.574163264129067 0.276117461859723 no 2420 0.282928662924331 3431 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1481 3346-2004 36 µM -0.574859466835985 0.275893619525957 no 2421 0.282693172403303 3482 2770522 SGTC_854 0422-0053 192 µM -0.575768466210001 0.275601493286152 no 2422 0.28238584526748 3493 3596728 SGTC_535 2293-4129 48.2 µM -0.57646524133704 0.275377672834523 no 2423 0.282150378716904 3511 396118 YIL048W NEO1 SGTC_1520 flindersine 88 µM -0.578934929048001 0.274585072516162 no 2424 0.281316540339018 3564 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2508 celastrol 40.54 µM -0.579504021126787 0.274402592666922 no 2425 0.281124567076553 3438 122724 Celastrol is a natural product and antioxidant. SGTC_2870 9038528 12.99 µM -0.579654385651992 0.274354388155536 no 2426 0.281073854803481 3483 6463316 SGTC_174 3553-0389 74.3 µM -0.579708793509443 0.274336946878744 no 2427 0.281055506177818 3507 738071 SGTC_2250 alverine citrate 130 µM -0.580063043825435 0.274223399869794 no 2428 0.280936052173693 3441 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_213 1246-0773 967 nM -0.580609627026608 0.274048250405132 no 2429 0.280751791240697 3437 6251622 SGTC_337 1315-0038 354 µM -0.580680758958464 0.274025460649624 no 2430 0.280727815958421 3437 1626437 SGTC_159 3970-0959 50 µM -0.583765378681635 0.273038090048441 no 2431 0.279689087076018 3590 6615653 SGTC_2116 5511452 16.8835 µM -0.583849815512411 0.273011087080005 no 2432 0.279660679680938 3497 870744 SGTC_3084 9116877 49.47 µM -0.584604268740916 0.272769871091939 no 2433 0.279406918366309 3438 27241325 SGTC_312 4092-0653 6.84 µM -0.58647625589226 0.272171810937245 no 2434 0.278777756561568 3487 1148278 SGTC_1800 st050079 29.0735 µM -0.587317321209788 0.271903320785555 no 2435 0.278495305062614 3474 3645560 SGTC_1151 3909-8316 15.3 µM -0.587797447346642 0.271750111003679 no 2436 0.278334128814487 3513 800431 SGTC_3111 9122088 49.47 µM -0.587823421038883 0.271741823940861 no 2437 0.27832541085591 3410 16876704 SGTC_1415 3966-0071 78.1 µM -0.588161021215696 0.271634122016464 no 2438 0.278212108912112 3499 2893185 SGTC_671 0560-0003 407 µM -0.588514673389714 0.271521321947365 no 2439 0.278093443885318 3413 3238678 SGTC_540 1187-0821 17.3 µM -0.588874100018987 0.271406703981208 no 2440 0.2779728665917 3433 847520 SGTC_1548 st061468 90.8 µM -0.590238342982099 0.270971878511053 no 2441 0.277515434657915 3465 390799 SGTC_250 brefeldin a 552.239 µM -0.591040007096101 0.270716526151372 no 2442 0.277246807646841 3425 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_819 1013-0258 27.7 µM -0.591218412643151 0.270659715362064 no 2443 0.27718704362087 3489 5753198 SGTC_20 0481-0013 4.944 µM -0.594168201722328 0.269721259568458 no 2444 0.276199809217876 3490 182045 SGTC_3133 9127736 49.47 µM -0.59564846569646 0.269250938297391 no 2445 0.275705046071045 3527 27243420 SGTC_178 4092-0806 87.505 µM -0.597119624713127 0.268783917835559 no 2446 0.275213758195859 3517 2169044 SGTC_3101 9120531 49.47 µM -0.597458554606574 0.268676381999024 no 2447 0.275100634981479 3596 24824904 SGTC_602 3130-1533 38.1 µM -0.597463825761635 0.268674709735188 no 2448 0.275098875830939 3545 720941 SGTC_2313 7726885 200 µM -0.598076732758975 0.26848030182959 no 2449 0.274894367234587 3488 726423 SGTC_2551 apiole 73.87 µM -0.600275532533578 0.267783447229557 no 2450 0.274161311121073 3422 10659 A possible DNA adduct former. SGTC_1701 st028638 40.4 µM -0.600716230968889 0.267643888587872 no 2451 0.274014503264887 3524 3490878 SGTC_2046 4110841 106 µM -0.602149250043269 0.267190339325921 no 2452 0.273537396887198 3540 44119630 YMR134W ERG29 SGTC_955 1216-0110 33 µM -0.602395137458343 0.267112555188874 no 2453 0.27345557299052 3494 3619719 SGTC_1954 st077032 68.9 µM -0.603226111712788 0.266849769042832 no 2454 0.273179139586946 3468 698907 SGTC_713 1488-1073 324 µM -0.603282572195169 0.266831918798478 no 2455 0.273160362365074 3507 3312542 SGTC_341 1486-1430 230 µM -0.603698802437381 0.266700344291172 no 2456 0.273021955238924 3472 2054753 YPL210C SRP72 SGTC_2571 chrysanthemic acid 100 µM -0.603729946319719 0.266690500720028 no 2457 0.273011600505238 3452 2743 An insecticide. SGTC_2820 7989630 71.43 µM -0.604797087020939 0.266353323152499 no 2458 0.272656914698312 3439 2984098 SGTC_399 oxolinic acid 75 µM -0.605364839691798 0.266174021955564 no 2459 0.272468303855907 3464 4628 A DNA gyrase inhibitor. SGTC_1895 st058434 18.3 µM -0.605505002342282 0.266129766787271 no 2460 0.272421750956767 3560 5393175 SGTC_1343 1487-0095 224 µM -0.605958320881929 0.26598666081891 no 2461 0.272271215131902 3533 4560101 YGL055W OLE1 SGTC_2103 5378138 10 µM -0.606572308750366 0.265792896091909 no 2462 0.272067390941485 3584 244142 SGTC_1125 tnp00248 1.32998 µM -0.607445208908051 0.265517546016637 no 2463 0.271777746874921 3556 24207736 SGTC_39 0986-0283 58.349 µM -0.608109770528253 0.265308011899875 no 2464 0.271557336241479 3588 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2777 climbazole 1.536 µM -0.608932934669879 0.265048587351069 no 2465 0.271284446467709 3498 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3231 9132313 49.47 µM -0.609279237889133 0.264939486577635 no 2466 0.271169683242004 3487 4905967 SGTC_680 0417-1641 114 µM -0.610192410401009 0.264651906473307 no 2467 0.270867178373773 3475 2835990 SGTC_2362 9071156 126 µM -0.612063934893659 0.264063014707568 no 2468 0.270247728881393 3557 653133 SGTC_3211 9128781 49.47 µM -0.612913697386895 0.263795849978883 no 2469 0.269966702917358 3468 17194361 SGTC_3284 9108171 64.8615 µM -0.613214466516364 0.263701321414177 no 2470 0.269867270256589 3479 8687505 SGTC_778 3456-2434 196 µM -0.616786675884488 0.262579936452903 no 2471 0.268687720787274 3535 5539063 SGTC_2114 5491910 81.25 µM -0.618090844064421 0.262171142065119 no 2472 0.26825772869507 3583 2849228 SGTC_1128 3448-9350 235 µM -0.618566373138588 0.262022167600978 no 2473 0.268101030073705 3475 619386 SGTC_2191 5911152 200 µM -0.618675484996206 0.261987990995881 no 2474 0.268065081510667 3500 2875902 SGTC_3 0833-0587 95.581 µM -0.619165314675236 0.261834592063376 no 2475 0.267903729566657 3501 5382644 SGTC_527 4476-4215 268 µM -0.619622275399485 0.261691528178902 no 2476 0.26775324890689 3442 4418754 SGTC_488 nitrendipine 139 µM -0.620089304686365 0.261545353516009 no 2477 0.267599496612493 3562 4507 Dihydropyridine L-type calcium channel blocker. SGTC_166 k072-0058 166.424 µM -0.620336007847376 0.261468155255755 no 2478 0.267518296597454 3574 5846229 SGTC_1607 st000305 50.6 µM -0.620802157078198 0.261322319959662 no 2479 0.267364901905015 3550 5457690 SGTC_2357 9067248 200 µM -0.621200439612399 0.261197749943276 no 2480 0.267233875116494 3530 9150235 SGTC_1202 1988-0068 29.6 µM -0.621933997687536 0.26096839636274 no 2481 0.266992634385384 3458 2850480 SGTC_2995 9067767 71.4286 µM -0.622483734171223 0.260796584178743 no 2482 0.266811918055166 3503 11673567 SGTC_1013 4112-3890 241 µM -0.622532265148854 0.26078141931987 no 2483 0.266795967308039 3484 705171 SGTC_1985 st071382 65.5 µM -0.622732148923043 0.260718964836949 no 2484 0.266730276296745 3588 6123237 SGTC_2891 9063876 19.48 µM -0.623059850631963 0.260616589786242 no 2485 0.266622596118483 3494 6472478 SGTC_2204 7233102 200 µM -0.623880672640282 0.260360253251236 no 2486 0.266352977037047 3493 2172480 SGTC_106 0092-0003 11.579 µM -0.624622334646654 0.260128749535598 no 2487 0.266109478701911 3502 1072148 SGTC_637 1181-0519 7.26 µM -0.625413498004982 0.259881911401638 no 2488 0.26584985267936 3561 6252091 YGR060W ERG25 SGTC_1614 st002383 48.6 µM -0.625619663992406 0.259817608724466 no 2489 0.265782218898324 3560 1947235 SGTC_344 k064-0035 6.43 µM -0.626204052351312 0.259635384020242 no 2490 0.265590554792527 3500 5088750 SGTC_2748 diazoxide 86.69 µM -0.626913455225375 0.25941426582562 no 2491 0.265357983430399 3499 3019 A potassium channel activatior. SGTC_663 1486-0733 13.9 µM -0.627399879046663 0.259262705597054 no 2492 0.265198573506479 3533 722445 YPR165W RHO1 SGTC_505 gw-5074 63.9 µM -0.627955256348876 0.259089716769301 no 2493 0.265016625748629 3555 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2415 st077333 57.7 µM -0.628136063098929 0.259033411993703 no 2494 0.264957405141647 3630 2766255 SGTC_2709 st078560 56 µM -0.629603319483318 0.258576729888863 no 2495 0.264477075606959 3596 17250903 SGTC_2312 7706453 155.7 µM -0.629716195005819 0.258541614772336 no 2496 0.264440142387504 3552 976098 SGTC_3330 9141424 71.43 µM -0.630383502356526 0.258334068634827 no 2497 0.264221851005472 3565 27261020 SGTC_1432 4049-0298 68.4 µM -0.633588875222173 0.257338337294108 no 2498 0.263174581442904 3584 741646 SGTC_2676 harmalol 100 µM -0.634171474961937 0.257157570357346 no 2499 0.262984460612791 3595 5459187 A monoamine oxidase inhibitor SGTC_1198 1612-1005 86.7 µM -0.634304706568487 0.25711624101492 no 2500 0.262940992766249 3640 6998509 SGTC_3041 9091929 49.47 µM -0.63555160163905 0.256729613260089 no 2501 0.26253436168328 3634 25236887 SGTC_3285 9112818 20.8695 µM -0.635930292307168 0.256612251681897 no 2502 0.262410928759637 3612 17017947 YPR165W RHO1 SGTC_1704 st028805 70.8 µM -0.636183878476841 0.256533677374284 no 2503 0.262328289832501 3552 2876101 SGTC_2481 5478948 45.16 µM -0.637040543533352 0.256268330278393 no 2504 0.262049217527859 3588 77792 SGTC_3083 9117465 49.47 µM -0.637624934945096 0.256087400511801 no 2505 0.261858930057235 3573 16420915 SGTC_2988 9073640 71.4286 µM -0.639568817137283 0.255486047054139 no 2506 0.261226480307131 3620 9102229 SGTC_3283 9109332 35.8195 µM -0.63980460204701 0.255413155560083 no 2507 0.261149820165138 3476 17027281 SGTC_2575 plumbagin 510 nM -0.639983340043869 0.255357907020401 no 2508 0.261091715244792 3550 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1094 duloxetine 25.4 µM -0.641010315269139 0.255040586477355 no 2509 0.260757990533979 3593 60834 A selective serotonin reuptake inhibitor. SGTC_2764 methyldopa 94.69 µM -0.641074140653724 0.255020872164135 no 2510 0.260737257155544 3619 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3126 9127922 49.47 µM -0.641315731917635 0.254946256946285 no 2511 0.260658785043718 3614 45595682 SGTC_873 0591-4978 488 µM -0.641420458535343 0.254913915785904 no 2512 0.260624772198165 3652 3305145 SGTC_3299 9121982 43.1275 µM -0.642098329274172 0.2547046310056 no 2513 0.260404670321532 3560 17594604 YPL160W CDC60 SGTC_2647 atorvastatin 60.16 µM -0.642811143471554 0.254484654923711 no 2514 0.260173325760833 3571 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_36 0335-0881 14.2 µM -0.64351268997738 0.254268253313473 no 2515 0.259945741619645 3538 23828853 SGTC_945 3381-0768 11.3 µM -0.643638954755196 0.254229315463934 no 2516 0.259904791789593 3610 1126236 YIL048W NEO1 SGTC_188 3229-0966 278.469 µM -0.644411696729081 0.253991083488722 no 2517 0.259654250850506 3654 5722370 SGTC_1191 1487-1166 10.6 µM -0.645325939759985 0.253709378885299 no 2518 0.259357993061433 3631 3955771 SGTC_1145 3546-0597 10.2 µM -0.645381191124911 0.253692359607686 no 2519 0.259340094615331 3551 875334 SGTC_2399 5884133 200 µM -0.645844432674716 0.253549689228766 no 2520 0.259190054584001 3600 722445 SGTC_2858 9025781 8.96 µM -0.647088935812793 0.253166612637212 no 2521 0.258787192820024 3631 4894980 YPL153C RAD53 SGTC_2086 5274770 176.623 µM -0.648190260011383 0.252827862705924 no 2522 0.258430950396256 3573 689278 SGTC_2363 9053361 176 µM -0.64878550121877 0.252644875294844 no 2523 0.258238515112956 3646 6469797 YMR079W SEC14 SGTC_435 c-PAF 6.7 µM -0.652737617129792 0.25143169804152 no 2524 0.256962723450926 3545 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2322 7413319 38.22 µM -0.653308880257249 0.251256592978704 no 2525 0.256778584305031 3624 1840400 SGTC_1966 st070145 16.1 µM -0.654230441827107 0.250974249498955 no 2526 0.256481675911664 3556 3748532 SGTC_1806 st050005 60.3 µM -0.654664383307293 0.250841358819601 no 2527 0.256341930756839 3562 5194765 SGTC_2130 NSC 7 2.4545 µM -0.6548892574423 0.250772507792668 no 2528 0.256269528608723 3587 21448 SGTC_3331 9141060 1.957 µM -0.655244550899598 0.250663745917998 no 2529 0.25615515741689 3580 4906567 YPR165W RHO1 SGTC_298 1391-0729 10 µM -0.655494273571433 0.250587316160289 no 2530 0.256074786054663 3585 3237558 SGTC_3181 9108277 49.47 µM -0.65590763055659 0.250460831858332 no 2531 0.255941779131076 3563 17097298 SGTC_973 1325-0077 65.9 µM -0.656597866991107 0.250249699852579 no 2532 0.25571976038547 3631 2835149 SGTC_233 rapamycin 362 pM -0.659173746600262 0.249462614540766 no 2533 0.254892101750183 3622 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2671 danthron 100 µM -0.659644876770294 0.249318798537179 no 2534 0.254740874213705 3579 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1063 disulfiram 1.84 µM -0.659750943094855 0.249286427079164 no 2535 0.25470683458479 3615 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1972 st070201 17.4 µM -0.660254943956823 0.249132636484801 no 2536 0.254545119266251 3597 2829099 SGTC_1444 4112-3581 28 µM -0.660519593339876 0.249051901704081 no 2537 0.254460224566676 3633 2877249 SGTC_1293 1000-1278 195 µM -0.660678678181011 0.249003377476927 no 2538 0.254409200189159 3655 678847 SGTC_23 0213-0011 39.996 µM -0.660729580577212 0.24898785223641 no 2539 0.254392875045214 3642 627608 SGTC_2013 4024628 200 µM -0.660743618186209 0.248983570853612 no 2540 0.254388373075008 3627 5230760 SGTC_1716 st033144 30.6155 µM -0.661680863718627 0.248697805485077 no 2541 0.254087885645459 3624 674617 SGTC_1872 amphotericin b 148 nM -0.663360827738137 0.248186023331598 no 2542 0.253549743831302 3611 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1325 1431-0015 227 µM -0.663624671264475 0.248105697430697 no 2543 0.253465281438896 3569 1103340 SGTC_1228 0124-0032 52.5 µM -0.665152293698639 0.247640892799652 no 2544 0.25297654506775 3650 X1228 SGTC_2041 5107442 45.335 µM -0.665403067977768 0.247564635004191 no 2545 0.252896361587061 3634 793005 SGTC_759 3486-0358 89.3 µM -0.666421018394698 0.247255215950557 no 2546 0.252571015822516 3650 875103 SGTC_2662 daunorubicin 22.37 µM -0.666993656893516 0.247081246072249 no 2547 0.252388092557569 3544 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1530 rhein 70.4 µM -0.667450172262796 0.246942601789942 no 2548 0.252242313628831 3658 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1350 1495-0454 146 µM -0.667941829377449 0.246793331491713 no 2549 0.252085362568589 3641 1069057 SGTC_1644 st010134 20.9 µM -0.668779108539368 0.246539239310011 no 2550 0.251818197651675 3616 3818134 SGTC_2663 amphotericin b 100 µM -0.669077773131723 0.246448636394361 no 2551 0.251722933839395 3607 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1735 st034310 56.75 µM -0.669454925636598 0.246334248875883 no 2552 0.251602662257491 3648 871153 SGTC_1867 st057372 64 µM -0.669957182439019 0.246181962360875 no 2553 0.25144254283793 3626 688837 SGTC_67 0335-0847 266 µM -0.670704797766347 0.245955375578183 no 2554 0.251204302922671 3694 4552207 YOR254C SEC63 SGTC_2257 7960413 200 µM -0.673188953636705 0.245203283559135 no 2555 0.250413543945613 3609 2974689 YIL048W NEO1 SGTC_1636 st007707 68.9 µM -0.674599080873157 0.244776910521339 no 2556 0.249965258553194 3658 403051 SGTC_2952 9073731 13.78 µM -0.676777036811154 0.244119158035603 no 2557 0.249273714914951 3648 16457353 SGTC_2199 6590217 200 µM -0.678317222954115 0.243654590881993 no 2558 0.248785290409041 3596 703109 SGTC_3194 9111903 49.47 µM -0.680838448514544 0.242895143751191 no 2559 0.247986859288691 3655 17087251 SGTC_3129 9127257 49.47 µM -0.681445579973392 0.242712454287078 no 2560 0.247794795110842 3565 837894 SGTC_214 4373-3496 70 µM -0.68271081781954 0.242331975843954 no 2561 0.247394796329452 3718 3779166 SGTC_63 0099-0242 26.702 µM -0.684712711331024 0.241730633413187 no 2562 0.24676261310973 3664 3898502 YLR359W ADE13 SGTC_2126 5251174 33.877 µM -0.685381708014872 0.241529856330528 no 2563 0.246551541866866 3676 790722 SGTC_3118 9124250 49.47 µM -0.685550500841167 0.24147921309402 no 2564 0.246498302310594 3591 1504786 SGTC_1967 st070177 51.4 µM -0.685587884727869 0.241467997514722 no 2565 0.246486511756829 3691 5729214 SGTC_2879 9041815 71.43 µM -0.687450202638396 0.240909639826277 no 2566 0.245899535499788 3609 4942971 SGTC_2692 st077426 47.7 µM -0.689682886155121 0.240241166378619 no 2567 0.245196815213915 3638 25238571 SGTC_442 cape 100 µM -0.691824888538705 0.239600794397694 no 2568 0.24452365237227 3628 5281787 SGTC_2302 7771753 200 µM -0.692430532016531 0.239419900635033 no 2569 0.244333498696005 3658 2203047 SGTC_1221 2958-7315 257 µM -0.697008506309785 0.238054965601118 no 2570 0.242898735212037 3678 4562705 SGTC_114 0364-0001 490.298 µM -0.697399463548251 0.237938598670232 no 2571 0.242776418588871 3678 4003655 SGTC_1022 4477-0945 21.3 µM -0.697783609651529 0.237824289430942 no 2572 0.242656265406896 3657 4648966 SGTC_2329 6138490 200 µM -0.700780446069896 0.236933564300354 no 2573 0.241720021448001 3687 720019 SGTC_2642 cholecalciferol 100 µM -0.700908834710389 0.236895445405981 no 2574 0.241679955300367 3661 9821465 A vitamin D precursor, similar to steriods. SGTC_1970 st070122 35.8 µM -0.703237103418522 0.236204762143586 no 2575 0.240954000066227 3705 102928 SGTC_2096 5468907 200 µM -0.704001735699389 0.235978175370566 no 2576 0.240715846345553 3713 759785 SGTC_1772 st048439 82.2 µM -0.704085717419215 0.235953296008998 no 2577 0.240689697060857 3659 2927068 YDL195W SEC31 SGTC_1162 k048-0130 20.1 µM -0.705224093048706 0.235616197896665 no 2578 0.240335395006313 3671 6797406 SGTC_2882 9058044 58.44 µM -0.705685056346272 0.235479772108284 no 2579 0.240192008072225 3635 18076804 SGTC_176 1486-1328 72.834 µM -0.706992907625142 0.235092940402877 no 2580 0.239785442641703 3705 22310231 SGTC_1105 epirubicin 18.1 µM -0.708047574172329 0.234781250628874 no 2581 0.239457857195677 3680 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3069 9117009 49.47 µM -0.708156571765483 0.234749051169029 no 2582 0.239424015860332 3590 41904981 SGTC_824 1304-0008 100 µM -0.70974853835202 0.234279039635253 no 2583 0.238930043319917 3704 768245 SGTC_3166 9102297 49.47 µM -0.710385629844909 0.234091091058723 no 2584 0.238732515960663 3664 25237072 SGTC_3105 9121040 49.47 µM -0.712540750625878 0.233455927557659 no 2585 0.238064993203033 3543 41448907 SGTC_2284 7945075 39.21 µM -0.712918003339319 0.233344840936421 no 2586 0.237948249008255 3763 1245402 SGTC_2806 7952793 58.44 µM -0.713105596293685 0.233289612843946 no 2587 0.237890208392802 3712 2972490 SGTC_1606 st000094 49.2 µM -0.713140990620817 0.233279193430425 no 2588 0.237879258380193 3709 1242210 SGTC_65 0798-0905 34.986 µM -0.714343745126953 0.232925279028393 no 2589 0.237507324171427 3792 3602145 SGTC_2801 7907800 81.82 µM -0.715659624789388 0.232538419069366 no 2590 0.237100773573832 3743 6620925 SGTC_1255 0566-0045 221 µM -0.716672835743025 0.232240785331837 no 2591 0.236787995427903 3737 2788469 SGTC_2999 9069765 71.4286 µM -0.718078603873257 0.231828188064849 no 2592 0.236354410968151 3729 2097066 SGTC_2955 9076254 12.21 µM -0.722364361934178 0.230572828336307 no 2593 0.23503524584635 3649 16459619 SGTC_1305 1181-0477 144 µM -0.72339125854798 0.230272600800786 no 2594 0.234719770095925 3718 6252086 SGTC_2917 7979103 53.79 µM -0.726305359571252 0.229421814387738 no 2595 0.233825797235098 3743 2980565 SGTC_227 fluconazole 33.516 µM -0.726977120964536 0.229225940448017 no 2596 0.233619985690125 3707 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_714 4296-0578 26.1 µM -0.727501247239181 0.229073179489266 no 2597 0.233459475780417 3738 1589775 SGTC_598 3937-0236 20.2 µM -0.728824793367365 0.228687675272816 no 2598 0.233054421690039 3790 1379313 SGTC_2420 aureobasidin a 50 nM -0.731236746441252 0.227986092625417 no 2599 0.232317279360657 3763 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_331 k048-0133 24.5 µM -0.731690242972251 0.227854316082821 no 2600 0.232178826534686 3696 6813582 SGTC_168 3970-0862 530.542 µM -0.733784494386556 0.227246326997084 no 2601 0.23154004608904 3732 3135186 SGTC_2002 4023503 131 µM -0.734848587561509 0.226937757196575 no 2602 0.231215856242471 3770 4736863 YCR052W RSC6 SGTC_2035 5154463 94.595 µM -0.736500731603459 0.226459130771817 no 2603 0.230713011250785 3720 2769623 SGTC_1337 1486-1011 40.3 µM -0.736642592710692 0.226418060173529 no 2604 0.230669863037029 3749 X1337 SGTC_2093 5331342 194.4 µM -0.738643291704229 0.225839280498604 no 2605 0.230061814486928 3747 33839 SGTC_2921 7974240 10.71 µM -0.738995826052922 0.225737383060748 no 2606 0.22995476594925 3775 2979074 YDR527W RBA50 SGTC_1488 4013-0813 75.9 µM -0.741295752705803 0.225073244991345 no 2607 0.229257068200881 3701 2910057 SGTC_229 benomyl 22.8748 µM -0.741731749832563 0.224947469280733 no 2608 0.229124939587119 3758 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_283 0987-0079 11.7 µM -0.742445981130655 0.224741515158794 no 2609 0.228908584631516 3768 411556 SGTC_1851 st056236 18.9 µM -0.744206306555234 0.224234368525009 no 2610 0.228375836639314 3728 5393171 SGTC_2405 ticlatone 3.52 µM -0.744798494924073 0.224063906287278 no 2611 0.228196772453271 3665 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1514 1189-1591 158 µM -0.744976049264452 0.224012811373264 no 2612 0.228143099476597 3760 767698 YMR146C TIF34 SGTC_850 0388-0143 75.9 µM -0.745186194077721 0.223952346434603 no 2613 0.228079583885357 3711 67273 SGTC_2275 7947463 200 µM -0.745694513782108 0.223806126026747 no 2614 0.227925987023429 3696 1225414 SGTC_813 k007-0158 173 µM -0.746133368748091 0.223679931117795 no 2615 0.227793426854931 3775 6523916 SGTC_2918 7977171 22.06 µM -0.746926787881597 0.22345188226015 no 2616 0.227553877492955 3692 2236483 SGTC_2977 9011197 71.43 µM -0.74774977476161 0.223215474699976 no 2617 0.227305550981208 3766 2704722 SGTC_3180 9109287 49.47 µM -0.748916584918938 0.222880546137149 no 2618 0.226953741736223 3760 18891271 SGTC_1508 1080-0625 72.9 µM -0.749770432279328 0.222635633917231 no 2619 0.226696489761891 3674 767111 SGTC_2167 5876490 200 µM -0.750068759481068 0.222550099792645 no 2620 0.226606646857212 3902 686534 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.750944559307427 0.222299105344557 no 2621 0.226343010983183 3784 804 An inhibitor of viral and cellular DNA polymerases. SGTC_816 0325-0417 81.3 µM -0.75241162191127 0.221879023653639 no 2622 0.225901779826115 3784 68101 SGTC_592 k241-0073 46.5 µM -0.752953606401928 0.221723945470639 no 2623 0.225738896640915 3754 4230158 SGTC_3250 9135583 49.47 µM -0.753143625949586 0.221669589786266 no 2624 0.225681805594087 3795 7699353 SGTC_469 w7 172 µM -0.754845144860943 0.221183204469275 no 2625 0.225170951378793 3797 45115570 A P450 inhibitor. SGTC_2827 7993847 71.43 µM -0.754872975752097 0.22117525398687 no 2626 0.225162601041247 3783 2985692 SGTC_107 0358-0022 2.6945 µM -0.755948371875041 0.22086816958997 no 2627 0.224840075231842 3781 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1519 esterone 74 µM -0.756986104660661 0.220572071703125 no 2628 0.22452909364475 3771 698 A steroid. SGTC_2707 st078556 66.6 µM -0.757202984259839 0.220510217859853 no 2629 0.224464131302735 3751 17250899 SGTC_1081 sertraline 6 µM -0.757356119959485 0.220466549699931 no 2630 0.22441826871235 3765 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2791 5663188 71.43 µM -0.758958243283196 0.220009985633612 no 2631 0.223938768004256 3737 54690634 SGTC_3340 9146634 11.102 µM -0.758981230508001 0.220003438813871 no 2632 0.223931892379216 3789 4907387 SGTC_2625 euphol 100 µM -0.759251441349968 0.219926490462434 no 2633 0.223851079592034 3761 6708538 A triterpene alcohol. SGTC_2906 7926292 26.41 µM -0.759338422528181 0.219901723986663 no 2634 0.223825069390632 3741 2966319 SGTC_2681 menadione 3.18 µM -0.759395052517794 0.219885600378486 no 2635 0.22380813610511 3796 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1790 st045711 43.5 µM -0.759965985971601 0.21972308294289 no 2636 0.223637458423493 3758 585119 SGTC_26 0302-0163 425.158 µM -0.76003899058995 0.219702306995303 no 2637 0.223615639398839 3803 3100915 SGTC_1567 st069303 68.4 µM -0.760622163228995 0.219536385879745 no 2638 0.223441388983694 3847 5581319 SGTC_3224 9130643 49.47 µM -0.761927755253313 0.219165186974297 no 2639 0.223051561796753 3788 17644395 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.761976876897433 0.219151228019546 no 2640 0.223036902487822 3755 77254 SGTC_938 3126-1755 342 µM -0.763196627721288 0.218804773977078 no 2641 0.222673069827486 3789 1777771 SGTC_3149 9097855 49.47 µM -0.764443004903589 0.218451082843494 no 2642 0.222301644644567 3789 25236625 YMR079W SEC14 SGTC_1474 0330-0125 5.35 µM -0.764925041738907 0.218314381013145 no 2643 0.222158090659363 3784 X1474 SGTC_661 1304-0007 33.6 µM -0.765787953163836 0.218069789280525 no 2644 0.221901241696389 3788 3117130 SGTC_2518 prenyletin 46.28 µM -0.767069302746035 0.21770688309034 no 2645 0.221520156036008 3742 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2297 7971671 152.32 µM -0.768483813708913 0.217306667619664 no 2646 0.221099901673929 3756 909016 SGTC_577 r071-0003 38.6 µM -0.76965847855735 0.216974636310733 no 2647 0.220751253129104 3827 4568517 YMR134W ERG29 SGTC_1861 st057647 17.4 µM -0.770088232974006 0.216853235027123 no 2648 0.220623777794324 3822 688668 SGTC_2176 5809774 33.9695 µM -0.773379242387844 0.215924860825207 no 2649 0.219648985503971 3787 2870539 SGTC_2458 5808907 16.39 µM -0.773438940344099 0.21590804167995 no 2650 0.219631325923453 3838 2731747 SGTC_3063 1327-0034 4 µM -0.776165086870767 0.215140793548335 no 2651 0.21882575872374 3678 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1178 0988-0033 191 µM -0.776353318195981 0.215087876102887 no 2652 0.218770199810857 3834 5392207 SGTC_2840 9008771 71.43 µM -0.777244920394382 0.214837322798754 no 2653 0.218507142193659 3768 2992978 SGTC_244 nsc-207895 1.295 µM -0.777344376353476 0.214809384729886 no 2654 0.218477810081165 3653 42640 SGTC_3287 9117173 37.0625 µM -0.777598565078907 0.214737990434195 no 2655 0.218402853612556 3781 2789709 SGTC_501 nsc-95397 161 µM -0.778793380955004 0.214402585827983 no 2656 0.218050718716 3803 262093 SGTC_2737 bleomycin 30.5 nM -0.779522802080988 0.214197975088013 no 2657 0.217835905468633 3832 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1671 st016596 74.5 µM -0.780060843808566 0.214047121232747 no 2658 0.217677531371753 3851 2829167 SGTC_487 nimodipine 119 µM -0.782115172593447 0.213471706325865 no 2659 0.217073445349846 3673 4497 L-type voltage-gated calcium channels inhibitor SGTC_3226 9131256 49.47 µM -0.782245379782459 0.213435265863176 no 2660 0.217035189923415 3682 17178073 SGTC_2223 6903751 107.57 µM -0.782603425339877 0.213335080062087 no 2661 0.216930014702963 3757 5598863 SGTC_1732 st034308 51.822 µM -0.784489398366198 0.212807813045558 no 2662 0.216376500129834 3690 830119 SGTC_2346 9031566 143.75 µM -0.784731761220007 0.212740110154022 no 2663 0.216305428333365 3790 4771086 SGTC_150 3970-0969 77.2 µM -0.787281963291429 0.212028486198483 no 2664 0.215558412897909 3906 6615640 SGTC_2805 7950783 58.44 µM -0.789269842103211 0.211474743120752 no 2665 0.214977154514099 3849 1178958 YDL195W SEC31 SGTC_131 0141-0277 33.849 µM -0.790975977687301 0.211000158395241 no 2666 0.21447900487371 3766 1547771 SGTC_306 1672-3436 11.6 µM -0.79158244252891 0.210831612513272 no 2667 0.214302093866099 3824 6797378 SGTC_1764 st044502 93.5 µM -0.791639361847957 0.210815797815452 no 2668 0.214285494369553 3867 8407 SGTC_1204 4049-0315 18.3 µM -0.792615508719729 0.210544689446062 no 2669 0.214000935096329 3926 588402 SGTC_2743 auranofin 4.32 µM -0.792996335378139 0.210438976756231 no 2670 0.213889978937662 3765 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1240 0356-0016 42.1 µM -0.793109060923496 0.210407691539994 no 2671 0.213857142091686 3826 4305613 SGTC_1804 st050076 49.1 µM -0.796177260267984 0.209557209723438 no 2672 0.212964506360671 3860 3895976 SGTC_1038 k292-0204 154 µM -0.798004151957129 0.209051770965519 no 2673 0.212434040347486 3788 4454212 SGTC_2785 7756463 72.73 µM -0.798397638967608 0.208943000544384 no 2674 0.212319886487573 3800 2201551 SGTC_163 TUB2.036 7.546 µM -0.799491656673811 0.20864075979428 no 2675 0.21200269129263 3864 15992207 YJR013W GPI14 SGTC_2394 5221648 200 µM -0.80095812180898 0.208236028707489 no 2676 0.211577945178524 3923 788586 SGTC_3144 9087057 49.47 µM -0.801341822078496 0.208130207420291 no 2677 0.211466892738157 3704 17249618 SGTC_1386 3228-0095 33.8 µM -0.802063552027534 0.207931246422246 no 2678 0.211258098575927 3847 870181 SGTC_735 3076-0345 636 µM -0.803185708199186 0.207622122123954 no 2679 0.210933702389463 3882 2888990 SGTC_1352 1496-0991 99 µM -0.803527299235149 0.207528076780189 no 2680 0.210835012268558 3828 3000039 SGTC_1968 st069590 43.6 µM -0.803920775543437 0.207419777819508 no 2681 0.210721365381563 3831 6384066 SGTC_3177 9107506 49.47 µM -0.80506784869864 0.207104252377537 no 2682 0.210390263941778 3739 8897194 SGTC_3075 9116269 49.47 µM -0.805639947448065 0.206946991340302 no 2683 0.210225242465158 3846 17015205 YNL244C SUI1 SGTC_1590 st077108 57.8 µM -0.806416086102823 0.206733755916382 no 2684 0.210001487385535 3804 5489485 SGTC_2919 7978188 46.38 µM -0.806829734181369 0.206620163889562 no 2685 0.209882292867346 3794 2980291 SGTC_2711 st079103 59.1 µM -0.807956715695049 0.206310870750718 no 2686 0.209557749993789 3816 54693780 SGTC_2052 5265182 7.135 µM -0.808229968456871 0.20623591956396 no 2687 0.209479104425925 3860 1239884 SGTC_2514 salinomycin 42.74 µM -0.808822467516641 0.206073456960127 no 2688 0.209308635432188 3935 23682228 A polyether potassium ionophore. SGTC_935 2996-0153 430 µM -0.809606267102622 0.205858656598235 no 2689 0.209083252501587 3814 23738523 SGTC_121 0557-0495 61.343 µM -0.81039531357611 0.205642552553007 no 2690 0.208856505234004 3987 3104427 SGTC_716 1683-5115 658 µM -0.810464888245184 0.205623503905298 no 2691 0.208836518604134 3830 723597 SGTC_1889 st059080 5.18 µM -0.811198622675492 0.205422680649684 no 2692 0.208625808232794 3802 176925 Isolated from Daphnopsis sellowiana. SGTC_1847 st056231 15 µM -0.811285774768188 0.205398834846781 no 2693 0.20860078863828 3851 5393180 SGTC_1665 st014639 11.4 µM -0.812054812871424 0.205188488548948 no 2694 0.208380090110445 3893 981133 YIL048W NEO1 SGTC_2772 vinpocetine 57.06 µM -0.813621956933211 0.204760241732111 no 2695 0.20793077767863 3840 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1340 1486-1359 257 µM -0.813642000137643 0.204754768055816 no 2696 0.207925034842809 3787 4309068 SGTC_3056 9094900 49.47 µM -0.814761521555271 0.204449171828624 no 2697 0.207604415118053 3835 25236784 SGTC_1739 st037196 92.5 µM -0.814763098250148 0.204448741629091 no 2698 0.207603963774529 3891 612214 SGTC_1721 st082152 9.2685 µM -0.817708196276447 0.203646115508689 no 2699 0.206761914602649 3798 5296051 SGTC_3190 9110366 49.47 µM -0.819107343699637 0.203265465809867 no 2700 0.206362586198046 3827 17123768 SGTC_202 3594-0513 34.79 µM -0.819440489921062 0.203174893238268 no 2701 0.206267570883261 3834 708429 SGTC_1135 dihydrocapsaicin 536.708 nM -0.819553147260912 0.203144270502256 no 2702 0.206235446197231 3790 107982 A Capsaicinoid. SGTC_784 4579-0127 173 µM -0.820026589250122 0.203015608708772 no 2703 0.206100474765406 3965 1948547 SGTC_1418 3966-3099 2.4 µM -0.822389725616911 0.202374134729341 no 2704 0.205427562500603 3827 740335 SGTC_861 0443-0273 110 µM -0.823255723460122 0.202139363210594 no 2705 0.205181293298096 3892 6149169 SGTC_2629 bisabolol 100 µM -0.823361296672827 0.202110753521569 no 2706 0.205151282787101 3891 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1696 st025591 34.7925 µM -0.824310185877693 0.201853719178668 no 2707 0.204881666218635 3864 2787147 SGTC_342 k048-0088 23.3 µM -0.82496433723254 0.201676637209666 no 2708 0.204695918963065 3866 6820570 SGTC_2217 6934799 96.0675 µM -0.826341317672182 0.201304186092126 no 2709 0.204305250828265 3792 675606 SGTC_2874 9043904 71.43 µM -0.826372242476886 0.201295826165578 no 2710 0.204296482139286 3842 4463428 SGTC_2333 9017922 200 µM -0.828560823710948 0.200704714008243 no 2711 0.203676481972705 3927 3163164 SGTC_1597 7-benzyloxygramine 47.5 µM -0.82871424580482 0.200663315476975 no 2712 0.203633061359331 3849 260807 SGTC_1803 st050068 52.4 µM -0.830134158075391 0.200280417879077 no 2713 0.203231468192006 3937 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2115 tiliquinol 12.7705 µM -0.831645262544843 0.199873411708683 no 2714 0.202804602817577 3872 71208 A bioactive hydroxyquinoline. SGTC_452 diindolylmethane 8 µM -0.834375186866666 0.199139386588344 no 2715 0.202034797597918 3890 3071 Inhibits expression of several cancer promoting factors. SGTC_563 tetrahydrosecaminediol 614 µM -0.834804243062831 0.199024169322305 no 2716 0.201913968229494 3938 334274 A psychoactive constituent of the cannabis plant. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.836491377261919 0.198571501800404 no 2717 0.201439262816706 3885 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1033 k072-0102 21.3 µM -0.8368065340103 0.198487012374211 no 2718 0.201350662019353 3843 5965931 SGTC_3096 9117468 49.47 µM -0.838996015328699 0.197900639828803 no 2719 0.200735772819899 3826 41316311 SGTC_392 N-ethylmaleimide 8.33 µM -0.839365965859502 0.197801665545134 no 2720 0.200631988137255 3835 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1830 st055982 50.3 µM -0.840176677316947 0.197584877409294 no 2721 0.20040466654358 3792 455313 An antimicrobial agent. SGTC_356 1634-0012 32.5 µM -0.840581833746448 0.197476590481117 no 2722 0.200291119633474 3856 735457 SGTC_2623 humulene 100 µM -0.843828038037903 0.196610267513318 no 2723 0.199382752667411 3874 6187145 An anti-inflammatory. SGTC_977 1348-1378 135 µM -0.844567642522631 0.196413209866087 no 2724 0.199176140793765 3885 X977 SGTC_664 1222-0054 14.9 µM -0.844675208757091 0.196384560266649 no 2725 0.199146102423217 3856 6813991 SGTC_1996 st072960 66.8 µM -0.844760069094724 0.196361960029468 no 2726 0.199122406705603 3867 1719405 SGTC_3068 9116768 49.47 µM -0.845961621708585 0.196042128470894 no 2727 0.198787077143899 3849 41904888 SGTC_301 4119-0100 24.5 µM -0.849648010578959 0.195062852123895 no 2728 0.19776040549884 3918 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_798 1287-0182 476 µM -0.851802460039648 0.194491909430459 no 2729 0.197161870381067 3893 1649755 SGTC_1048 3161-0300 24.5 µM -0.852025559637256 0.194432844804259 no 2730 0.197099952994366 3895 2165101 SGTC_991 3996-0057 64.7 µM -0.852247740692948 0.194374034210968 no 2731 0.197038302228853 3967 715343 SGTC_1365 1672-3266 55.4 µM -0.854310196585209 0.193828625962544 no 2732 0.196466569484609 3925 6415873 SGTC_1401 3807-4679 7.6 µM -0.855132216975088 0.193611506193861 no 2733 0.196238977954301 3855 3291456 SGTC_609 0986-0026 86.3 µM -0.855269678285991 0.193575213098026 no 2734 0.196200934857691 3871 2848610 SGTC_404 fumagillin 50 µM -0.857827551926739 0.192900630049772 no 2735 0.195493846797818 3896 12015870 A methionine aminopeptidase binder. SGTC_264 promethazine 12.5 mM -0.858891059730667 0.192620576331497 no 2736 0.19520031115338 3862 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1267 0828-0272 9.49 µM -0.859991030834266 0.192331182290671 no 2737 0.194896993327081 3990 745334 SGTC_742 0kpi-0133 140 µM -0.862146905808914 0.191764759759909 no 2738 0.194303341217625 3983 2728852 SGTC_1470 k295-0292 231 µM -0.863546466709273 0.191397594327726 no 2739 0.193918541468143 3994 5045612 SGTC_1686 st019653 115.5 µM -0.864065275150092 0.191261597926208 no 2740 0.193776016685935 3867 97252 SGTC_1611 st001856 99.4 µM -0.865666789485473 0.190842163221357 no 2741 0.193336458661055 3905 647478 SGTC_2316 5844804 197.44 µM -0.866536855665183 0.190614530690089 no 2742 0.193097912091187 3982 776813 SGTC_287 k060-0039 29.6 µM -0.868438189007567 0.190117671536348 no 2743 0.192577248150063 3963 5861974 SGTC_3236 9132701 49.47 µM -0.869163911492646 0.189928234749826 no 2744 0.192378741714862 3930 24282524 SGTC_1018 4259-0013 28.1 µM -0.869588761024743 0.189817389300178 no 2745 0.192262590964202 4006 6801262 SGTC_1615 st002656 86.5 µM -0.870431433537817 0.189597649394669 no 2746 0.192032337417325 3923 1584458 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.872338594714526 0.189100905791733 no 2747 0.191511844318416 3858 756377 SGTC_245 methotrexate 289.6 µM -0.872629295232567 0.189025259723547 no 2748 0.191432583735798 3922 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_682 0kpi-0099 17 µM -0.875868181995704 0.188183698105004 no 2749 0.190550849321213 3987 1714895 YML126C ERG13 SGTC_313 3474-0040 5.03 µM -0.876057168458575 0.188134665149149 no 2750 0.19049947792366 3939 1043375 YIL048W NEO1 SGTC_3271 9137798 49.47 µM -0.877661053189722 0.187718851183607 no 2751 0.190063843064109 3861 6498326 SGTC_2485 5633444 17.78 µM -0.877959725000245 0.187641481988092 no 2752 0.189982787793657 3966 5724239 SGTC_2741 miltefosine 3.04 µM -0.878103060328276 0.187604358801956 no 2753 0.189943896176126 3901 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1547 harmine 94.2 µM -0.878678877426274 0.187455270577399 no 2754 0.189787707273554 3932 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2736 butenafine 14.65 µM -0.879017767039245 0.187367560895432 no 2755 0.189695821270834 3882 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1167 k781-0610 148 µM -0.879982905997533 0.187117907589865 no 2756 0.189434284960939 3958 4525169 SGTC_1338 1486-1223 76 µM -0.884713957696904 0.185897100992446 no 2757 0.188155462877356 3974 3444526 SGTC_2745 rifampicin 24.3 µM -0.886331071650648 0.18548095407918 no 2758 0.187719575147137 3945 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3318 9139014 38.6185 µM -0.887524926222946 0.185174099735869 no 2759 0.187398176159236 3950 16643984 SGTC_630 4356-0227 183 µM -0.887765524671095 0.185112297334386 no 2760 0.187333445575097 3931 779312 SGTC_1741 st038134 10.228 µM -0.888506811604203 0.184921963899388 no 2761 0.187134096724134 4020 1272587 SGTC_3142 9086498 49.47 µM -0.888846125477465 0.184834881982006 no 2762 0.187042891325419 3886 25236367 SGTC_2863 9028737 58.44 µM -0.890022865892663 0.184533079431448 no 2763 0.186726804124187 3935 6460917 SGTC_3136 9095672 49.47 µM -0.891335120453874 0.184196882798717 no 2764 0.186374706353902 3690 17217380 SGTC_2386 9075165 157.42 µM -0.89161249699758 0.184125868394886 no 2765 0.186300334717577 3924 16452277 SGTC_2207 7258803 200 µM -0.89305350205511 0.183757214196271 no 2766 0.185914260948086 3925 3666799 SGTC_3183 9108214 49.47 µM -0.894122011017845 0.183484153262171 no 2767 0.185628306827402 3907 4974831 SGTC_1792 st045773 43.6 µM -0.895676776419937 0.183087279945774 no 2768 0.18521270862633 3884 2919270 SGTC_2412 st077135 33.4 µM -0.895896933039003 0.183031125531153 no 2769 0.185153906170505 4058 13258915 SGTC_3262 9137218 49.47 µM -0.896405742058292 0.182901386894855 no 2770 0.185018050837288 3768 17650664 SGTC_1604 st002052 72.4 µM -0.896601975505541 0.182851365661198 no 2771 0.184965671777455 4029 6254834 YHR062C RPP1 SGTC_699 0375-0592 111 µM -0.896982723772626 0.182754334710357 no 2772 0.184864067905229 4034 762578 SGTC_2628 lathosterol 100 µM -0.898188720635676 0.182447207313258 no 2773 0.184542472848336 4060 6710616 SGTC_634 1611-4317 11.2 µM -0.898388799614758 0.182396285035153 no 2774 0.184489152805313 3958 2843522 SGTC_941 3237-0776 460 µM -0.89977212314536 0.18204445710782 no 2775 0.18412076623423 4012 760008 SGTC_2938 9059746 27.26 µM -0.900303517086142 0.181909417779826 no 2776 0.183979374957892 3995 6471769 SGTC_3065 9113888 49.47 µM -0.901399988192534 0.181630977504804 no 2777 0.183687843844962 4039 16648368 SGTC_1369 1866-0067 208 µM -0.902387072481779 0.181380543404194 no 2778 0.183425642965782 3944 3531355 SGTC_2986 9022445 71.43 µM -0.904681705818985 0.180799205720741 no 2779 0.182817017807767 3990 6459286 SGTC_1768 st044301 37.178 µM -0.910054164744952 0.179442686154762 no 2780 0.181396972648244 3982 3931349 SGTC_1736 st036774 51 µM -0.913319489491221 0.178621342237736 no 2781 0.180537267520227 4065 1272247 SGTC_393 acivicin 6.25 µM -0.913727343122058 0.178518919294366 no 2782 0.180430066334263 3837 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_546 peri-Naphthalide 147 µM -0.914160475951475 0.178410188579885 no 2783 0.180316264438876 3893 223824 A penicillin ester. SGTC_2004 4023728 41.89 µM -0.91458224854255 0.178304349766321 no 2784 0.180205490641939 3989 360084 YDR527W RBA50 SGTC_126 0417-1624 672.48 µM -0.914677274958949 0.178280509480085 no 2785 0.18018053892621 4032 41912 YDL195W SEC31 SGTC_1946 st076057 65.1 µM -0.916186664391931 0.177902102311477 no 2786 0.179784499366356 3892 953009 SGTC_827 3253-0474 693 µM -0.920362114546354 0.176857949248509 no 2787 0.178691779804614 4028 5402065 SGTC_899 1083-0020 478 µM -0.921162903061504 0.176658139956145 no 2788 0.178482691525665 4062 767123 SGTC_1130 3454-2858 15.9 µM -0.921304012834232 0.176622945652804 no 2789 0.178445863318813 4046 715628 YIL048W NEO1 SGTC_290 2043-6722 48.1 µM -0.921787417143181 0.1765024130043 no 2790 0.178319736033873 4012 773758 YLR208W SEC13 SGTC_2742 clothiapine 36.27 µM -0.921875027886912 0.176480573599826 no 2791 0.178296883118398 3949 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1311 1190-0148 100 µM -0.92389997749739 0.17597627520749 no 2792 0.177769197405548 4060 1961333 SGTC_2533 agelasine 13.65 µM -0.924470039052284 0.175834470445813 no 2793 0.17762082181306 4064 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1938 st074717 56.4 µM -0.924899859029088 0.175727599128644 no 2794 0.177508999983109 3836 17250979 SGTC_438 sphingosine 6.67 µM -0.926863805518965 0.175239803204313 no 2795 0.176998625823384 3958 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2839 9003951 25.97 µM -0.927728402877168 0.17502533100853 no 2796 0.176774235657932 4058 2990634 SGTC_81 0411-0046 9.971 µM -0.930152901277659 0.174424798171146 no 2797 0.17614596189325 3931 12925265 SGTC_3114 9122766 49.47 µM -0.930416236641168 0.174359650570686 no 2798 0.176077807532537 4006 17176985 SGTC_855 0428-0020 25 µM -0.930460971084769 0.174348585072089 no 2799 0.176066231379328 4035 6812414 SGTC_2142 5622915 118.518 µM -0.931584663868579 0.174070775134012 no 2800 0.175775605911655 4010 5322196 SGTC_299 1273-0059 1.44 µM -0.934022170975926 0.173469119488363 no 2801 0.175146228279544 3889 2848077 SGTC_268 camptothecin 39.6153 µM -0.936732743111952 0.172801618846122 no 2802 0.174448024542656 3979 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_439 amiodarone 34.4 µM -0.938969671707221 0.172251991470004 no 2803 0.17387315792811 3877 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2515 chrysin 20.77 µM -0.940828936113252 0.171796008395176 no 2804 0.173396264851786 4045 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1192 1488-0095 21.4 µM -0.941635768145862 0.171598373576985 no 2805 0.173189575323926 4067 915875 SGTC_3155 9099265 49.47 µM -0.944667456842223 0.170857055554523 no 2806 0.172414338151709 4057 25236499 SGTC_1501 4491-0275 38.4 µM -0.945242677466524 0.170716632443695 no 2807 0.172267497927211 3944 5104718 SGTC_2080 5212524 12.4 µM -0.945597621298686 0.170630020265181 no 2808 0.172176928981248 3921 260183 SGTC_2309 7664088 163.95 µM -0.945784630030829 0.170584398351876 no 2809 0.172129223279427 4048 704922 SGTC_2740 felodipine 17.08 µM -0.946078199573622 0.17051279603751 no 2810 0.172054351061468 4028 3333 L-type calcium channel blocker SGTC_1317 1273-0028 910 nM -0.948251272485542 0.169983376958673 no 2811 0.171500775387817 3999 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1217 1183-1422 255 µM -0.95010268469938 0.1695331552962 no 2812 0.171030039603095 4049 2849664 SGTC_2491 paeonol 100 µM -0.952398247718945 0.168975989640135 no 2813 0.170447523903009 3901 11092 Increases levels of cortical cytochrome oxidase. SGTC_381 3461-2219 42.7 µM -0.952474766620954 0.16895743769807 no 2814 0.170428128586651 4043 2883159 SGTC_263 alizarin 107.927 µM -0.95431852367206 0.168510815996433 no 2815 0.16996121718722 4044 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2384 9036245 200 µM -0.954408795832443 0.168488968467539 no 2816 0.169938377822256 3983 6462766 SGTC_1078 idebenone 36.1 µM -0.955154091291629 0.168308662804134 no 2817 0.169749889059416 4088 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1096 rimcazole 32.2 µM -0.955698506527571 0.168177033572965 no 2818 0.1696122886341 3965 18528119 A dopamine reuptake inhibitor. SGTC_1246 0422-0085 105 µM -0.957089564452853 0.167841003178305 no 2819 0.169261025181786 4074 264295 SGTC_2927 9011802 47.9 µM -0.960338190076036 0.167057934909134 no 2820 0.16844251766309 4072 43912568 SGTC_1442 4112-3290 3 µM -0.961552082841232 0.166765936477416 no 2821 0.16813732559179 4011 704353 SGTC_3313 9133968 57.047 µM -0.962248924751013 0.166598462017042 no 2822 0.16796228922799 4036 1494643 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.962740015001914 0.166480501803436 no 2823 0.167839005111101 4096 688788 SGTC_24 0417-1663 219 µM -0.963098680221974 0.166394384251477 no 2824 0.167749002016864 4051 4329390 SGTC_1060 3448-7350 82 µM -0.965312833186823 0.165863390584828 no 2825 0.167194072958672 4019 570178 SGTC_2605 digitonin 300 nM -0.96640476230799 0.165601930069284 no 2826 0.166920840999502 4098 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_194 1486-1323 56.904 µM -0.967024138830556 0.165453739988388 no 2827 0.166765983332972 4105 5178754 SGTC_2739 tacrine 100.86 µM -0.967656166415831 0.165302611513442 no 2828 0.166608058209114 4096 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2591 skatole 100 µM -0.967975758149138 0.165226225745777 no 2829 0.166528238381023 4101 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2374 9071832 200 µM -0.968262235917868 0.165157773981909 no 2830 0.166456709935686 3956 17381698 SGTC_219 mitoxanthrone 164.414 µM -0.968520125494265 0.165096168859492 no 2831 0.16639233642511 4008 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2886 9058944 51.95 µM -0.970864545004506 0.164536812165239 no 2832 0.165807867890049 3899 4949929 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.971120484624701 0.164475821799526 no 2833 0.165744142071655 4071 229346 A bile salt which induces apoptosis. SGTC_2958 9077254 16.72 µM -0.973859633277671 0.1638240009512 no 2834 0.165063119511924 4138 16457351 SGTC_485 niflumic acid 177 µM -0.973993180561801 0.163792264324042 no 2835 0.165029962614997 4114 4488 A COX2 inhibitor. SGTC_415 dibenzyl ketone 100 µM -0.974104634230901 0.163765781153133 no 2836 0.165002294385357 4052 7593 SGTC_1523 st012844 44.7 µM -0.977923856990328 0.162859952511577 no 2837 0.164055992392979 4174 4274103 SGTC_84 0443-0269 128.823 µM -0.978081733509359 0.16282257821876 no 2838 0.164016950707438 3943 6150058 SGTC_1569 carminic acid 40.6 µM -0.978633778874394 0.162691935728266 no 2839 0.163880481399013 4166 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_988 1497-1057 103 µM -0.979681021967137 0.162444291253962 no 2840 0.163621798438372 3999 3533044 SGTC_1238 0333-0287 48.8 µM -0.980023528587798 0.162363351030155 no 2841 0.163537252315874 4028 7226 SGTC_2101 5377231 179.231 µM -0.983221854293281 0.161608798803523 no 2842 0.162749130527316 4111 2844213 SGTC_638 3970-0837 4.09 µM -0.984164950231001 0.161386739758002 no 2843 0.162517208059598 4040 4118451 YLR208W SEC13 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.986952973884872 0.160731442794251 no 2844 0.161832846427588 4062 140250 A respiratory chain inhibitor. SGTC_310 1273-0058 1.06 µM -0.988341679956674 0.160405690546913 no 2845 0.161492669603719 3949 2734232 SGTC_2298 7976326 193.81 µM -0.98865863393609 0.160331402369097 no 2846 0.161415094094498 3951 2235818 SGTC_1138 3761-0006 1.03 µM -0.989895695180386 0.160041673153629 no 2847 0.161112551918424 4090 12061087 SGTC_408 cantharidin 100 µM -0.990191256482185 0.159972501134405 no 2848 0.161040322697127 4029 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_644 1498-1197 63.3 µM -0.991224893323699 0.159730746559937 no 2849 0.1607878889069 4121 6741615 SGTC_3003 9075612 71.4286 µM -0.99279157586839 0.15936477532352 no 2850 0.160405768052899 4102 6501993 SGTC_1709 st033179 39.1045 µM -0.993173073375314 0.159275742108204 no 2851 0.160312809025175 4049 573381 SGTC_1435 4092-0789 56.7 µM -0.993442054136332 0.159212987436465 no 2852 0.16024728798171 4070 2248285 SGTC_2847 9005661 71.43 µM -0.994110805925389 0.159057034205936 no 2853 0.160084462551995 4073 2991449 SGTC_737 1950-0117 57.9 µM -0.995102632620861 0.158825924105132 no 2854 0.159843175190815 4044 5393513 SGTC_2443 5493264 126.67 µM -0.995282526057366 0.158784029901124 no 2855 0.159799436985312 4109 5340055 SGTC_3208 9114115 49.47 µM -0.996278339471045 0.158552252484598 no 2856 0.159557462561056 4100 650895 SGTC_1040 k898-0338 155 µM -0.998653225485984 0.158000389368989 no 2857 0.158981353379754 4107 20969351 SGTC_1231 0242-0792 125 µM -0.998817505908735 0.1579622614663 no 2858 0.158941552056318 4080 3707635 SGTC_1188 1403-0014 4.57 µM -0.999087578897498 0.15789959325883 no 2859 0.15887613384848 4080 9614867 SGTC_1821 st053465 65.6 µM -0.999226106412719 0.157867455427989 no 2860 0.158842585982964 4092 675086 SGTC_3119 9125183 49.47 µM -0.999340372414197 0.157840949404687 no 2861 0.158814917138069 3898 22695334 SGTC_125 0133-0007 11.75 µM -1.00269064612489 0.157065093231766 no 2862 0.15800507222093 4168 26541 SGTC_770 0389-1121 67.2 µM -1.00326313405962 0.156932767869349 no 2863 0.157866959274012 4194 6753108 SGTC_2983 9022671 12.99 µM -1.00886150979732 0.155642620929852 no 2864 0.15652052840096 4120 6405161 SGTC_3205 9113483 49.47 µM -1.01067693513787 0.155225762050255 no 2865 0.156085539900585 4151 17018033 SGTC_653 0203-0016 55.2 µM -1.01242042370828 0.154826115705891 no 2866 0.155668538569071 4145 295302 SGTC_790 1575-0012 79.1 µM -1.01480681384603 0.154280204869492 no 2867 0.155098962531856 4168 378741 YLR208W SEC13 SGTC_3344 9148862 3.898 µM -1.01547164206584 0.154128345685979 no 2868 0.154940528812334 4166 4905352 SGTC_2141 5621638 7.665 µM -1.01605676673293 0.153994774117042 no 2869 0.154801177532465 4132 2856238 SGTC_797 k781-0471 270 µM -1.01687408841372 0.153808325139046 no 2870 0.154606665653319 4080 23738129 SGTC_2763 lisinopril 49.32 µM -1.01750819346351 0.15366377486185 no 2871 0.154455868256468 3979 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3071 9117417 49.47 µM -1.01876059328674 0.153378542746854 no 2872 0.154158319084277 4060 45595590 YGL055W OLE1 SGTC_998 3996-0085 177 µM -1.02296974005622 0.152422487854733 no 2873 0.153161076661923 4141 715391 SGTC_1854 st056233 32.9 µM -1.02310245888199 0.152392406898302 no 2874 0.15312970224432 4028 5393174 SGTC_1345 1488-0192 31.4 µM -1.02435549125372 0.152108599115085 no 2875 0.152833698307979 4175 658348 SGTC_1004 4084-0029 199 µM -1.0245238153514 0.152070501010548 no 2876 0.152793964022104 4134 716894 YLR208W SEC13 SGTC_297 0986-0032 24 µM -1.02463175718615 0.15204607302937 no 2877 0.152768487071087 4055 2847425 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.025258381498 0.151904315110195 no 2878 0.152620643842293 4058 4330530 SGTC_2589 lobaric acid 100 µM -1.02869705511822 0.151127965456464 no 2879 0.151811027100605 4120 73157 A novel microtubule depolymerizer. SGTC_1726 st035556 14.5795 µM -1.03064693774748 0.150688915206814 no 2880 0.151353208184687 4216 5919439 SGTC_1253 0550-0034 176 µM -1.03165396523054 0.150462498249323 no 2881 0.151117125045653 4159 5969915 SGTC_1009 4106-0057 9.87 µM -1.03292102679234 0.150177938167248 no 2882 0.150820428910309 4135 2928005 SGTC_3342 9147791 14.508 µM -1.03293253237832 0.15017535585645 no 2883 0.15081773653113 4028 1838168 SGTC_2269 7935389 174.42 µM -1.0330628002854 0.150146120625026 no 2884 0.15078725525703 4082 97605 SGTC_516 3992-2719 87.3 µM -1.0357785586462 0.149537503524135 no 2885 0.150152731370162 4050 5350887 YDR037W KRS1 SGTC_2640 pentamidine 10.38 µM -1.03597398833375 0.149493770196593 no 2886 0.150107138912523 4121 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1487 3970-0795 2.82 µM -1.03867475420987 0.148890265983259 no 2887 0.149478013114299 4163 3765103 SGTC_2373 9071805 200 µM -1.03995672831907 0.148604370841103 no 2888 0.149180002439031 4148 10149009 SGTC_518 1021-0119 62.6 µM -1.04062773339541 0.148454875323904 no 2889 0.14902417734162 4099 1097762 SGTC_2060 5238662 140 µM -1.04193759345854 0.148163337002234 no 2890 0.148720306645659 4129 790130 SGTC_3039 9090270 49.47 µM -1.04228614100334 0.148085824614682 no 2891 0.148639517910198 4155 17173750 SGTC_143 4032-1194 15.74 µM -1.04358654110236 0.147796872277 no 2892 0.148338361238954 4148 1806963 SGTC_3269 9137823 49.47 µM -1.04543975813209 0.14738573534586 no 2893 0.147909884709492 4046 17682936 SGTC_3073 9114972 49.47 µM -1.04606653742584 0.147246857713829 no 2894 0.147765156709254 4145 41905075 SGTC_490 phenamil 164 µM -1.04722133625506 0.146991214736152 no 2895 0.147498753458589 4113 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1320 1313-0481 95.3 µM -1.0475240647259 0.146924247651885 no 2896 0.147428969584825 4132 6813365 YLR208W SEC13 SGTC_1280 0880-0253 10.1 µM -1.04772773106351 0.146879205787996 no 2897 0.147382033606452 4120 6836607 SGTC_1565 sinapyl alcohol 95.1 µM -1.04988920800495 0.146401754757328 no 2898 0.146884526958326 4183 5280507 A phenol propionate derived from cinnamic acid. SGTC_3152 9099253 49.47 µM -1.05015507823404 0.146343098436414 no 2899 0.146823409561927 4070 25236131 SGTC_3323 9138564 53.9225 µM -1.05038788465717 0.146291749615957 no 2900 0.146769906778409 4165 43912313 YNL103W MET4 SGTC_2973 9094665 17.96 µM -1.05184762514894 0.145970058543531 no 2901 0.146434732321789 4186 25237061 YIL048W NEO1 SGTC_936 3005-4620 401 µM -1.05304784396571 0.145705916021718 no 2902 0.14615953248232 4212 777207 SGTC_1760 st045453 10.4495 µM -1.0557026479815 0.145122792441236 no 2903 0.145552043503091 4198 3323419 YIL048W NEO1 SGTC_791 1348-1292 225 µM -1.05779088471849 0.144665219526068 no 2904 0.145075394705523 4131 5437054 SGTC_3246 9135460 32.98 µM -1.05870954643053 0.144464231165157 no 2905 0.144866039436256 4121 41446951 SGTC_2997 9067075 71.4286 µM -1.05881403446648 0.144441382792336 no 2906 0.144842240383524 4160 27209819 SGTC_2694 st077685 81.9 µM -1.06046866891804 0.144079888894921 no 2907 0.144465718197726 4095 2838096 SGTC_1351 1496-0003 46.5 µM -1.06124028991751 0.143911518864519 no 2908 0.144290356821312 4169 3891978 SGTC_864 0469-0573 172 µM -1.06141736753114 0.143872898726078 no 2909 0.144250133773613 4138 689425 SGTC_373 0844-0104 25.9 µM -1.06328473068995 0.143466057604918 no 2910 0.143826423777851 4174 5375804 SGTC_1552 6-methylflavone 10.6 µM -1.06556338423681 0.142970662005324 no 2911 0.143310529319543 4076 689013 SGTC_512 prima-1 270 µM -1.06843685223514 0.142347599228744 no 2912 0.142661750517736 4168 322968 A re-activator of the apoptotic function of mutant p53. SGTC_801 0866-0028 10.1 µM -1.07148026989178 0.141689691736039 no 2913 0.141976768728007 4185 6849771 SGTC_1158 4092-0494 91.8 µM -1.07237624500418 0.141496398361499 no 2914 0.141775536618907 4268 1148199 SGTC_2915 7971052 15.16 µM -1.07298269478345 0.141365667241586 no 2915 0.141639440312927 4078 5741558 SGTC_1900 st060200 72.8 µM -1.07333486058083 0.141289789176248 no 2916 0.141560449728057 4154 688945 SGTC_2687 chenodiol 100 µM -1.07867421304453 0.140142748139229 no 2917 0.140366492542016 4256 5702181 A cholesterol synthesis inhibitor. SGTC_2648 atorvastatin 78.68 µM -1.08005204149368 0.139847782096856 no 2918 0.14005950319375 4179 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1169 aniline yellow 25.8 µM -1.08067157408435 0.139715289950607 no 2919 0.139921615993789 4099 6051 A DNA damaging agent. SGTC_1307 1187-1599 12.2 µM -1.08150703937427 0.139536753999485 no 2920 0.139735815547154 4150 1538471 SGTC_2341 7987486 176.74 µM -1.08208580028162 0.139413165870811 no 2921 0.139607202382726 4210 1258686 SGTC_42 0133-0086 60.653 µM -1.0820996911157 0.139410200548841 no 2922 0.139604116529116 4053 162923 Model of phenazepam hydroxylation. SGTC_262 fenpropimorph 62.5 µM -1.08288891319899 0.139241793187159 no 2923 0.139428866749255 4148 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_517 1365-0151 113 µM -1.08290856415685 0.139237601754359 no 2924 0.139424505089289 4224 768657 SGTC_56 0957-0365 83.25 µM -1.08293431101004 0.139232110233171 no 2925 0.13941879054554 4152 6752360 SGTC_1878 temozolomide 1 mM -1.08353419696138 0.139104202865055 no 2926 0.139285690269285 4095 5394 DNA alkylating agent. SGTC_1074 carmofur 3.8 µM -1.08578538438502 0.138624919243302 no 2927 0.138786977073214 4219 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3128 9127691 49.47 µM -1.08744936151231 0.138271378139312 no 2928 0.138419133157646 4224 41316314 SGTC_1801 st050089 28.441 µM -1.08833476338508 0.138083509755267 no 2929 0.138223674568164 4221 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_375 3970-0961 9.27 µM -1.08857304665884 0.138032979524831 no 2930 0.138171104037598 4130 2898222 SGTC_2576 guaiol 23.12 µM -1.09016988343169 0.137694680574251 no 2931 0.137819158540229 4094 227829 SGTC_1458 k015-0034 6.33 µM -1.09110033870117 0.137497819454411 no 2932 0.137614366914092 4215 3598957 SGTC_1245 0418-0076 17.2 µM -1.09409456450811 0.136865620478012 no 2933 0.136956753050578 4235 6790114 SGTC_2778 tioconazole 65.09 nM -1.09470360336127 0.136737271940125 no 2934 0.136823254735535 4080 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2177 5811945 192 µM -1.0962442341293 0.136412967633152 no 2935 0.136485953253985 4244 5343475 SGTC_3310 9130229 44.1445 µM -1.09724868964863 0.136201812321725 no 2936 0.136266347046525 4227 7761258 SGTC_519 k048-0011 62.8 µM -1.09791350978423 0.136062177789928 no 2937 0.136121129074846 4235 6836379 SGTC_2780 5215298 71.43 µM -1.0992878399878 0.135773833090535 no 2938 0.135821267326859 4215 2834131 SGTC_2406 ethylparaben 405.7 µM -1.09996373529445 0.135632178858892 no 2939 0.135673961449013 4194 8434 A possible steroid mimic. SGTC_1398 3558-0053 112 µM -1.10355804554604 0.134880583851065 no 2940 0.134892449499222 4113 4532369 SGTC_3164 9100705 49.47 µM -1.10584373274949 0.13440411982161 no 2941 0.134397081216652 4216 17174235 SGTC_1106 tegaserod maleate 11.7 µM -1.10987808455493 0.133565959917185 no 2942 0.1335257826978 4226 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2525 harmine 47.85 µM -1.11021347895075 0.133496441980337 no 2943 0.133453522909978 4184 5280953 A monoamine oxidase inhibitor SGTC_2690 usnic acid 100 µM -1.11237667480423 0.133048669469942 no 2944 0.132988114599351 4233 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3219 9131112 49.47 µM -1.11323256470271 0.132871789600128 no 2945 0.132804280051286 4111 17612988 YMR079W SEC14 SGTC_1610 st001799 48.1 µM -1.11441432051659 0.132627831871843 no 2946 0.13255074128399 4132 621897 SGTC_3011 9081274 71.4286 µM -1.11486354099526 0.132535177283468 no 2947 0.132454451203527 4201 6625322 SGTC_396 dithiazanine 1.25 µM -1.11544073290127 0.132416193249818 no 2948 0.132330801310375 4198 10578 An antihelmenthic. SGTC_2426 5582046 32.21 µM -1.11700177403042 0.13209476449289 no 2949 0.131996783332821 4227 2251934 SGTC_2361 9034121 116 µM -1.12054518243416 0.131367150995223 no 2950 0.131240754949556 4225 6496917 SGTC_3025 9087895 49.47 µM -1.12274797236343 0.130916221292978 no 2951 0.130772273745122 4202 17173641 SGTC_2667 digitoxin 100 µM -1.12300300457661 0.130864083216207 no 2952 0.130718109194353 4150 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2797 7859098 81.82 µM -1.12371560589402 0.130718477057471 no 2953 0.130566846880136 4205 972681 SGTC_1011 4112-3381 17.4 µM -1.12435231407326 0.130588472950506 no 2954 0.130431796656944 4290 2877139 SGTC_1668 st014914 51.6 µM -1.12494087482884 0.130468379202499 no 2955 0.130307044796388 4226 2839556 SGTC_21 0849-0113 22.993 µM -1.12761154345623 0.12992439845823 no 2956 0.129742004731895 4177 1560156 SGTC_890 0929-0006 47.2 µM -1.12894677581926 0.129653018429554 no 2957 0.129460143414855 4192 1378169 SGTC_357 1325-0123 420 µM -1.12905893586232 0.12963024028891 no 2958 0.129436486284843 4232 1098503 SGTC_2812 7970281 58.44 µM -1.13094439401133 0.129247744951425 no 2959 0.129039248225506 4263 2233435 SGTC_2385 9074692 200 µM -1.13206378663699 0.129021028709803 no 2960 0.128803809133605 4245 17046906 SGTC_75 0159-0059 199.013 µM -1.13231922250152 0.128969332661792 no 2961 0.128750125723095 4307 5377270 SGTC_2960 9079389 5.97 µM -1.13401151545377 0.128627203041801 no 2962 0.128394858840577 4231 16457355 SGTC_3257 9139206 32.98 µM -1.13568993608804 0.128288500576967 no 2963 0.128043176985085 4222 4910041 SGTC_2008 4012253 172 µM -1.13702275781444 0.128019980899395 no 2964 0.127764386043586 4222 603940 SGTC_1295 1013-0063 9.78 µM -1.13806273729816 0.127810730659357 no 2965 0.127547143162884 4255 6826038 SGTC_3281 9140613 49.47 µM -1.13884113722715 0.127654267442835 no 2966 0.127384710179431 4243 16013766 SGTC_1717 st033143 58.0435 µM -1.13950062297846 0.127521810947252 no 2967 0.127247204297787 4294 674616 SGTC_91 0417-1751 58.384 µM -1.14119998254391 0.12718093821794 no 2968 0.126893355807033 4334 6795624 SGTC_1479 0549-0158 134 µM -1.14166157716234 0.127088457032965 no 2969 0.12679735885767 4288 5440202 SGTC_1072 oxiconazole 14.9 nM -1.14169563073428 0.12708163620198 no 2970 0.126790278804771 4219 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_134 0269-0018 6.916 µM -1.14544955168462 0.126331298208182 no 2971 0.126011490955673 4195 4378915 SGTC_564 3555-0129 330 µM -1.14565822499413 0.126289679115239 no 2972 0.125968297692913 4095 563260 SGTC_2859 9028643 45.46 µM -1.14582030959329 0.126257358556341 no 2973 0.12593475494613 4089 17151580 SGTC_3001 9076041 71.4286 µM -1.14741772625608 0.125939133261979 no 2974 0.125604509243201 4214 16004211 SGTC_2665 lovastatin 100 µM -1.14803318929047 0.125816674748664 no 2975 0.125477431443552 4253 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_419 nsc-638432 893 µM -1.15054463966981 0.125317833175168 no 2976 0.124959809699197 4192 368090 SGTC_2746 daunorubicin 9.88 µM -1.15117154280979 0.125193528998146 no 2977 0.124830834988242 4192 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_348 k064-0012 10.7 µM -1.15129693659078 0.125168675891185 no 2978 0.12480504850722 4165 5066323 SGTC_645 0845-0943 5.41 µM -1.15192627869544 0.125043992026724 no 2979 0.124675684289378 4251 1885106 SGTC_2828 7998861 71.43 µM -1.15650626989524 0.124139227012464 no 2980 0.123737068233985 4226 2988188 SGTC_2616 abietic acid 100 µM -1.15677085168159 0.124087099882977 no 2981 0.123682996828207 4287 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1691 st019933 84.6 µM -1.15691317460349 0.124059066172986 no 2982 0.123653917768454 4241 6176082 SGTC_1746 st038117 42 µM -1.15888502798933 0.123671121148982 no 2983 0.123251526249641 4294 2898218 SGTC_3043 9092303 49.47 µM -1.16076286493981 0.12330246345296 no 2984 0.122869174284437 4249 25236084 SGTC_96 0929-0093 37.281 µM -1.16178081979803 0.123102940306827 no 2985 0.122662253468487 4262 6991579 SGTC_1334 1486-0610 236 µM -1.16397655141871 0.122673339096346 no 2986 0.122216757275584 4323 3742339 SGTC_1510 1123-0200 71.5 µM -1.16435313332438 0.12259976554046 no 2987 0.122140466109925 4291 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_700 3453-2283 142 µM -1.16472707368037 0.12252673870689 no 2988 0.122064743185188 4308 565664 SGTC_210 3551-0445 56.827 µM -1.16575586573041 0.122325983360925 no 2989 0.12185658292447 4298 2865180 YOR207C RET1 SGTC_2920 7982904 15.77 µM -1.16691776220686 0.12209953217163 no 2990 0.121621791034342 4257 6456808 SGTC_1164 k060-0068 93.7 µM -1.16749111714095 0.121987895031835 no 2991 0.121506046748438 4252 5963676 SGTC_2078 5212016 200 µM -1.16942607503295 0.121611671356118 no 2992 0.121116004671695 4137 1899708 SGTC_916 4466-0038 42 nM -1.17209316628054 0.121094433095556 no 2993 0.120579826632205 4307 5722064 YGL116W CDC20 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.17358964377262 0.120804894723359 no 2994 0.120279715661689 4132 4000243 SGTC_2237 6667747 47.222 µM -1.17499145533026 0.120534114622987 no 2995 0.119999067160936 4270 729940 YDL015C TSC13 SGTC_1400 3771-8998 51.5 µM -1.17551766533808 0.1204325799904 no 2996 0.119893836972876 4191 670767 SGTC_1296 1068-0102 11.9 µM -1.17871287766681 0.119817342509639 no 2997 0.119256263022565 4256 767053 SGTC_1625 st003711 30.1 µM -1.1790111757105 0.119760018587476 no 2998 0.119196862871915 4332 24207034 YER133W GLC7 SGTC_468 gf-109203x 121 µM -1.18055164223723 0.119464295015252 no 2999 0.118890441861298 4279 2396 A protein kinase C inhibitor. SGTC_697 0508-1955 564 µM -1.18170887900405 0.119242479260993 no 3000 0.118660617013524 4267 6243113 SGTC_2989 9073649 71.4286 µM -1.18243943636491 0.119102597935577 no 3001 0.118515691549458 4242 21367202 SGTC_2588 indole-3-carbinol 100 µM -1.18614936345225 0.11839403847896 no 3002 0.117781659576741 4296 3712 Induces cell cycle arrest. SGTC_2523 spermine 47.74 µM -1.18677372610268 0.118275084920848 no 3003 0.117658442537763 4304 1103 A DNA binding polyamine. SGTC_1703 st026983 48.3 µM -1.18970689896706 0.117717387900726 no 3004 0.117080806429884 4305 1104023 SGTC_695 3505-6186 243 µM -1.19050971299988 0.117565070279457 no 3005 0.116923057347484 4264 1819379 SGTC_2783 7738165 71.43 µM -1.19373734799111 0.116954100475107 no 3006 0.116290363064129 4276 17201110 SGTC_2747 doxorubicin 7.63 µM -1.19465954112366 0.11677994950509 no 3007 0.116110037989484 4274 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_559 1550-0661 158 µM -1.19871711731905 0.116015883232178 no 3008 0.115318979931999 4338 5830875 SGTC_2263 7948595 193.29 µM -1.19874097386778 0.116011401417851 no 3009 0.11531434025587 4294 2971371 SGTC_2754 granisetron 64.02 µM -1.20048809304601 0.115683512631859 no 3010 0.114974917114111 4282 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2201 6605497 169.863 µM -1.20214374863187 0.115373397162279 no 3011 0.114653919439036 4220 670741 SGTC_1712 st032288 53.4 µM -1.20323088000604 0.11517009172969 no 3012 0.114443494113953 4123 2883011 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.20450454811603 0.114932226060764 no 3013 0.114197312617915 4315 5282362 SGTC_423 5-fluorouracil 457 µM -1.20499089069931 0.114841490722036 no 3014 0.114103409253348 4221 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_717 1532-0246 73.2 µM -1.20591830821596 0.11466860674305 no 3015 0.11392449530638 4264 9561992 SGTC_631 k072-0230 41.5 µM -1.20842645093145 0.114201980768454 no 3016 0.113441635278701 4287 5773147 SGTC_2524 avocatin b 10.57 µM -1.20879552116512 0.114133431610612 no 3017 0.113370706364101 4278 6710748 SGTC_3027 9089541 49.47 µM -1.21308635679272 0.113338624838001 no 3018 0.112548402802147 4294 9943819 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.22005157068541 0.112056853281754 no 3019 0.111222662884754 4294 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1891 st059073 26.2 µM -1.22331754194539 0.111459415933627 no 3020 0.110604892043383 4385 688754 SGTC_265 mycophenolic acid 32.932 µM -1.23027045465188 0.110195134213408 no 3021 0.109297922158248 4362 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_561 1550-0330 72.9 µM -1.23120291574685 0.110026365687798 no 3022 0.109123490587376 4258 6812934 SGTC_1773 st048542 73.5835 µM -1.23237524078293 0.109814446822701 no 3023 0.108904472657954 4276 3237138 SGTC_2084 5306078 60.6385 µM -1.23247733935353 0.109796004544948 no 3024 0.108885413210425 4254 679340 SGTC_2212 7123476 200 µM -1.23370689970168 0.109574081071231 no 3025 0.108656070977264 4305 1085715 SGTC_1557 sumaresinolic acid 42.3 µM -1.23422851297379 0.109480032405529 no 3026 0.108558882731299 4284 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2158 5657123 3.6195 µM -1.2376226396738 0.108869475423424 no 3027 0.107928007897899 4291 2858827 SGTC_137 0438-0332 85.389 µM -1.23796835923884 0.108807422848145 no 3028 0.107863896602674 4275 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2463 5473429 200 µM -1.23834984447368 0.108738980275618 no 3029 0.107793184648878 4304 5399405 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.24071884726686 0.108314648593538 no 3030 0.107354814659611 4261 1241132 A phosphatase inhibitor. SGTC_2146 5545642 200 µM -1.24104169978537 0.108256912202172 no 3031 0.107295172353136 4275 825326 SGTC_2506 ethyl hematommate 54.16 µM -1.24351083706557 0.107816083597023 no 3032 0.106839825004825 4370 3940691 An allergen. SGTC_2336 9001819 198.65 µM -1.24470772446357 0.107602862628203 no 3033 0.106619602773431 4376 2989602 SGTC_1054 3429-0080 167 µM -1.24891143257757 0.106856395815983 no 3034 0.1058487348051 4347 1162877 SGTC_3178 9107506 49.47 µM -1.25197767238856 0.106314274640301 no 3035 0.105288999965555 4326 8897194 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.25220675011711 0.106273852838714 no 3036 0.105247268501113 4348 6728940 SGTC_2063 5246145 200 µM -1.25500681238109 0.105780665997034 no 3037 0.104738143480957 4371 711240 SGTC_3100 9120536 49.47 µM -1.25880465639956 0.105114382490541 no 3038 0.104050449032395 4209 16421196 SGTC_2678 equilin 100 µM -1.26060376494258 0.104799814098407 no 3039 0.103725820755582 4323 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2770 toltrazuril 17.5 µM -1.26080054270926 0.104765449533879 no 3040 0.103690359116908 4290 68591 Kills coccidiodes. SGTC_378 3970-0959 8.33 µM -1.26493361227137 0.104045549790596 no 3041 0.102947563515563 4359 6615653 SGTC_3296 9122258 64.045 µM -1.26880325104069 0.103374792011748 no 3042 0.10225562266695 4320 4730474 SGTC_2646 retinol 96.75 µM -1.27441933155241 0.102406900762644 no 3043 0.101257422403165 4359 445354 A vitamin A analog and teratogen. SGTC_3168 9103419 49.47 µM -1.27462964763188 0.102370782738699 no 3044 0.101220179304009 4367 16649256 SGTC_1445 4239-0156 97.7 µM -1.27762046200462 0.101858166074955 no 3045 0.100691641085351 4415 4008346 SGTC_1666 st014829 29 µM -1.28293483426766 0.100951912628522 no 3046 0.0997574537719016 4334 3858230 SGTC_537 1334-0398 209 µM -1.2840460906876 0.100763156799874 no 3047 0.099562914475539 4380 5846986 SGTC_2151 5563267 85.4165 µM -1.28607819606296 0.10041865327834 no 3048 0.0992078863944487 4412 5310824 SGTC_738 1315-0003 72.4 µM -1.28916959732152 0.0998962164878722 no 3049 0.0986695660450326 4381 6251474 SGTC_1835 st008666 49.2 µM -1.29277463462131 0.0992894874967821 no 3050 0.0980445078721532 4301 690455 SGTC_858 0438-0351 2.77 µM -1.29793602659718 0.098425520081112 no 3051 0.0971546594928279 4338 2799119 SGTC_702 1488-0190 94 µM -1.29815153037671 0.0983895669189201 no 3052 0.0971176349471079 4397 949357 SGTC_1271 0832-2808 169 µM -1.29985006284218 0.0981065320605071 no 3053 0.0968261816094742 4401 3663794 SGTC_2567 aureobasidin a 60 nM -1.30158532786121 0.0978179927637274 no 3054 0.0965290890549839 4467 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2933 9026794 32.47 µM -1.30661123189407 0.0969857978975413 no 3055 0.0956723900253963 4308 17586027 SGTC_2831 7999036 19.48 µM -1.30959311499184 0.096494517304728 no 3056 0.0951667594198584 4372 2988270 SGTC_1176 0848-0131 83.3 µM -1.31042228658349 0.0963582324740832 no 3057 0.0950265091428825 4424 6769040 SGTC_1930 st074634 34.3 µM -1.31059957146823 0.0963291118270198 no 3058 0.0949965420469599 4283 684253 YOR116C RPO31 SGTC_3040 9091894 49.47 µM -1.31612328077406 0.0954250300221404 no 3059 0.0940663341001574 4236 25236966 SGTC_1793 st048256 72.231 µM -1.31854310271625 0.0950309439888124 no 3060 0.0936609530391944 4332 672022 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.3185699096315 0.0950265850068449 no 3061 0.0936564694417618 4332 279621 SGTC_1472 k841-0093 193 µM -1.32071678792078 0.0946779664147367 no 3062 0.0932979071388355 4494 X1472 SGTC_475 α-linolenic acid 10 µM -1.32241791828833 0.0944024002263215 no 3063 0.0930145127143 4388 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2976 9009005 19.48 µM -1.32424052426738 0.0941078129802846 no 3064 0.0927115880719712 4387 2993148 SGTC_3270 9137563 49.47 µM -1.32748563347064 0.0935849867200606 no 3065 0.0921740446032629 4376 17015724 SGTC_1136 pergolide 1.05886 µM -1.3285498969143 0.0934139889724432 no 3066 0.0919982556498499 4322 47811 A dopamine receptor agonist. SGTC_2220 6782180 200 µM -1.32992411686836 0.0931935313251874 no 3067 0.0917716372466252 4315 833803 SGTC_2910 7948405 25.97 µM -1.33036719714282 0.0931225327129393 no 3068 0.091698658467735 4336 2971328 SGTC_1521 st012942 49.4 µM -1.33118632524421 0.09299138195791 no 3069 0.0915638549117484 4333 24207259 SGTC_1066 ketoconazole 628 nM -1.33317062185794 0.0926742419453153 no 3070 0.0912379089419705 4449 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1503 4585-0012 61.3 µM -1.3345288760075 0.0924576207683326 no 3071 0.0910152949284157 4414 2922052 SGTC_15 0266-0086 27.098 µM -1.33566962338598 0.0922759783040469 no 3072 0.0908286411538804 4460 1712902 YIL048W NEO1 SGTC_958 1222-0007 33 µM -1.33855346240014 0.0918179595016063 no 3073 0.0903580424240465 4446 7312461 SGTC_2327 6189656 200 µM -1.33985949320611 0.0916110871838908 no 3074 0.0901455147043084 4463 5349088 SGTC_2852 9023854 51.95 µM -1.34083793283438 0.0914563310064037 no 3075 0.0899865387040567 4419 19798528 SGTC_2 0422-0095 29 µM -1.34252291548378 0.0911902778392518 no 3076 0.0897132526874039 4294 6790840 SGTC_1248 0469-0687 58.6 µM -1.34334956627698 0.0910599624665851 no 3077 0.0895794046690777 4366 4017482 SGTC_2391 6285546 200 µM -1.34479825025046 0.0908319213894523 no 3078 0.0893451977437946 4402 846083 SGTC_3335 9143315 29.6265 µM -1.34724460563387 0.0904477966831672 no 3079 0.0889507331351482 4405 4899691 SGTC_1139 k015-0024 46.9 µM -1.34772163171871 0.0903730351724176 no 3080 0.0888739659500432 4427 2766652 SGTC_2965 9082772 38.63 µM -1.34867940055357 0.0902230682384461 no 3081 0.0887199824227113 4403 16459634 SGTC_211 3455-0679 143.504 µM -1.34872679350363 0.0902156522781401 no 3082 0.0887123680703902 4398 748649 SGTC_2829 7992743 58.44 µM -1.34888940802658 0.0901902101034036 no 3083 0.0886862454314292 4384 16462845 SGTC_1262 0737-0114 49.6 µM -1.35439974855129 0.0893312262731129 no 3084 0.0878044388985632 4434 765919 SGTC_1980 st071811 45.7 µM -1.35480073211134 0.0892689570054296 no 3085 0.0877405266519423 4471 4974850 SGTC_1453 4237-0541 195 µM -1.36149559514647 0.0882340686866061 no 3086 0.0866785623077768 4406 739892 SGTC_3124 9127567 49.47 µM -1.36665692618586 0.0874423572706331 no 3087 0.0858664325088549 4371 17592030 SGTC_786 4544-0069 423 µM -1.36796724136376 0.0872422107391757 no 3088 0.0856611651450957 4393 748821 YLR208W SEC13 SGTC_1924 st058459 75.1 µM -1.37094293537245 0.0867889535490377 no 3089 0.0851963727976325 4373 688683 SGTC_2246 7293507 91.5585 µM -1.37135175866649 0.0867268193892688 no 3090 0.0851326640443008 4470 887656 SGTC_2757 clomiphene 4.22 µM -1.3754422991715 0.0861069563793048 no 3091 0.0844971814010773 4432 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2669 eugenol 100 µM -1.37614977390057 0.0860000857153655 no 3092 0.0843876341438959 4430 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2306 7482397 179.52 µM -1.38779694496957 0.0842549111583419 no 3093 0.0825994426861928 4437 891448 SGTC_2557 derrustone 83.84 µM -1.39312005352701 0.0834662203030243 no 3094 0.0817917449685386 4406 629853 An antioxidant. SGTC_986 1493-0483 84 µM -1.39469626750862 0.0832337508462023 no 3095 0.08155372546433 4381 40079 SGTC_1906 st060206 94.7 µM -1.39639399563689 0.0829839046668838 no 3096 0.0812979411123002 4459 5133468 SGTC_2083 5306046 65.942 µM -1.40265538360801 0.0820673231672128 no 3097 0.0803598139432212 4416 539837 SGTC_1540 guanosine 70.6 µM -1.40850421981142 0.081218042980829 no 3098 0.0794909091599351 4373 6802 Guanosine is a purine nucleoside SGTC_2782 7736369 71.43 µM -1.41047995978809 0.0809326591133956 no 3099 0.0791990048827803 4438 2950836 YOL077C BRX1 SGTC_2461 5755302 26.15 µM -1.41177901680515 0.0807454309631344 no 3100 0.0790075193557541 4467 2788904 SGTC_934 2950-0684 338 µM -1.41266647827436 0.0806177126774628 no 3101 0.0788769061849046 4446 1121253 SGTC_3251 9135047 49.47 µM -1.41304171853216 0.080563756204546 no 3102 0.0788217289956777 4487 17682963 SGTC_2909 7941780 10.49 µM -1.41581649672846 0.0801656121790347 no 3103 0.0784146191536071 4407 1243215 SGTC_2025 5147754 141 µM -1.4171439154366 0.0799756718620122 no 3104 0.0782204276181835 4413 315777 YLR208W SEC13 SGTC_3064 1327-0027 10 µM -1.41740077575508 0.0799389570498951 no 3105 0.0781828930079066 4388 16000455 YPR107C YTH1 SGTC_2435 5706476 10.6 µM -1.4243266205168 0.0789537967015583 no 3106 0.0771759724601764 4440 5725375 SGTC_2934 9036370 36.88 µM -1.42576212675494 0.0787507599444285 no 3107 0.076968508286652 4426 6462800 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.4258655088425 0.0787361529581998 no 3108 0.0769535835403881 4448 688751 SGTC_807 1315-0151 48 µM -1.42625367085974 0.0786813273796163 no 3109 0.0768975661985176 4466 4011080 SGTC_761 k216-0224 480 µM -1.4289138639388 0.0783063691940586 no 3110 0.0765144960791768 4455 1340404 SGTC_1877 wortmannin 25 µM -1.42935551809432 0.0782442487575018 no 3111 0.0764510382476434 4480 312145 A covalent inhibitor of PI 3-kinase. SGTC_1796 st049173 110.4 µM -1.43256707719202 0.0777936535451227 no 3112 0.0759907980151202 4447 94134 SGTC_432 NS 1619 61.3 µM -1.43492624361314 0.0774639093841413 no 3113 0.0756540581924138 4426 4552 A K+/calcium channel activator. SGTC_1971 st069429 63.5 µM -1.43517431297463 0.0774292981324936 no 3114 0.0756187157276282 4457 1246522 YGL099W LSG1 SGTC_253 dyclonine 31.25 µM -1.4359214242431 0.0773251302695186 no 3115 0.0755123507061077 4545 3180 An oral anasthetic. SGTC_572 0960-0087 17.7 µM -1.43728367575598 0.077135468994767 no 3116 0.0753187026747841 4408 6796365 SGTC_2175 5807670 165.306 µM -1.43900750273673 0.0768959738308838 no 3117 0.0750741985159971 4416 241186 SGTC_365 0121-0052 13.6 µM -1.4464963244635 0.075862093112166 no 3118 0.074019021095069 4456 3101739 SGTC_232 clozapine 119 µM -1.44771706610909 0.0756945699498352 no 3119 0.0738480975246096 4484 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_547 1120-0019 610 nM -1.44817387748341 0.0756319539406657 no 3120 0.0737842141601931 4444 3676939 SGTC_3277 9138724 49.47 µM -1.44870975859516 0.0755585499996761 no 3121 0.0737093270366942 4423 15943418 SGTC_3230 9131665 49.47 µM -1.45169851919069 0.0751501507486284 no 3122 0.0732927256243323 4477 15943720 SGTC_2549 cedrol 20.94 µM -1.45286912371241 0.074990652985613 no 3123 0.0731300475960599 4415 6708665 A sedative which affects the nervous system. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.45362298793569 0.0748880738792324 no 3124 0.0730254300041374 4464 688662 SGTC_457 grayanotoxin iii 135 µM -1.46015672772836 0.0740035003669502 no 3125 0.0721235024478262 4298 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1042 0350-0096 82 µM -1.46083588635773 0.073912012110857 no 3126 0.0720302424302874 4458 3122515 SGTC_1055 3448-0672 86 µM -1.46249478487375 0.073688908229461 no 3127 0.0718028362095238 4442 748378 SGTC_3042 9091578 49.47 µM -1.46352473844048 0.0735506498930257 no 3128 0.07166192475159 4458 25236497 SGTC_1216 1165-0504 9.65 µM -1.46775017525456 0.0729855134325776 no 3129 0.0710860479994441 4497 6304004 SGTC_3160 9100216 49.47 µM -1.47312538580252 0.072271409472965 no 3130 0.0703586147389729 4461 17191039 SGTC_1397 3532-0190 20.1 µM -1.4799230855659 0.0713760081377364 no 3131 0.069446887018378 4450 5322280 SGTC_216 k038-0035 28.382 µM -1.48230472518555 0.0710643179373718 no 3132 0.0691296157976835 4412 4444231 YPR107C YTH1 SGTC_887 0885-0007 9.62 µM -1.48504950762933 0.0707064001750913 no 3133 0.0687653550152532 4513 5719458 SGTC_38 0929-0051 58.268 µM -1.48516553322771 0.0706913010878563 no 3134 0.0687499898932438 4448 1379719 SGTC_182 3448-4371 550.524 µM -1.48658765407761 0.0705064334671594 no 3135 0.0685618752586627 4418 3491403 SGTC_212 3807-4682 38.772 µM -1.49634708617068 0.069247773965525 no 3136 0.0672816153900364 4555 3125501 YBL034C STU1 SGTC_2156 5649887 115 µM -1.49634727505419 0.0692477497741313 no 3137 0.0672815907920528 4512 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_55 0767-0285 6.563 µM -1.49928404071319 0.068872407779035 no 3138 0.0668999803969979 4413 3116166 SGTC_421 streptovitacin 30 mM -1.50244189992816 0.0684705603105079 no 3139 0.0664915110911509 4492 91467 include heat shock SGTC_1107 amlodipine 47 µM -1.50351793799163 0.0683340450620815 no 3140 0.0663527673942019 4093 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2861 9024595 19.48 µM -1.50403765433896 0.0682681847343815 no 3141 0.0662858358192802 4429 16482810 SGTC_361 000s-0510 1.45 µM -1.50656966712368 0.0679480194341724 no 3142 0.0659604986521233 4395 660 SGTC_884 0851-0618 334 µM -1.50915071354242 0.0676228485687912 no 3143 0.0656301360558357 4517 9642473 SGTC_89 0302-0250 142.109 µM -1.51008482300114 0.0675054623601232 no 3144 0.0655108908131916 4572 4203518 YLR208W SEC13 SGTC_576 1073-0113 22.7 µM -1.5102840739557 0.0674804435911354 no 3145 0.0654854768680902 4572 5439563 SGTC_2708 st078559 56 µM -1.51035203768 0.0674719114256736 no 3146 0.0654768100194259 4458 17250902 SGTC_3095 9117207 49.47 µM -1.51493441631424 0.066898560534755 no 3147 0.0648945067913856 4499 17015229 SGTC_380 3970-0968 6 µM -1.51745283284219 0.0665850631522537 no 3148 0.0645761967510202 4401 2891601 SGTC_1969 st069479 40.1 µM -1.51790962963206 0.0665283222293004 no 3149 0.0645185910263622 4494 3895485 SGTC_2045 5106652 78.05 µM -1.5194516231547 0.0663370602136841 no 3150 0.0643244281205799 4505 673349 SGTC_718 1130-0073 349 µM -1.52143671016831 0.0660914660819837 no 3151 0.064075141211625 4518 6740020 SGTC_1088 bifonazole 369 nM -1.52194255392276 0.0660289960606173 no 3152 0.0640117376746196 4500 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2790 5423970 71.43 µM -1.52356431802569 0.0658290220177884 no 3153 0.0638087911769334 4526 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_763 3453-1109 128 µM -1.52426604477552 0.0657426401849829 no 3154 0.0637211328300211 4539 1560353 SGTC_2195 6536160 144.242 µM -1.52690497813917 0.0654185765952817 no 3155 0.0633923207635059 4507 3834386 SGTC_2272 7805186 180 µM -1.53133147301464 0.0648777825399543 no 3156 0.0628437454322454 4517 2956062 YPR165W RHO1 SGTC_3297 9117502 71.43 µM -1.53215270204258 0.064777834063076 no 3157 0.0627423785304107 4534 7453720 SGTC_1412 3909-8563 178 µM -1.53305513911656 0.064668140008496 no 3158 0.0626311348529593 4598 23767530 SGTC_1493 4348-0038 111 µM -1.54523205165533 0.0632020662524652 no 3159 0.0611450721148746 4507 800424 SGTC_2296 7971656 126.45 µM -1.54768305475081 0.0629101241216738 no 3160 0.0608493119181881 4518 666570 SGTC_1886 st057356 49.9 µM -1.54821296851502 0.0628471437534344 no 3161 0.0607855150408853 4507 24207747 SGTC_2216 7189485 200 µM -1.5591716906751 0.0615556801179368 no 3162 0.0594778746326225 4547 731273 SGTC_275 trichlorophene 5.69 µM -1.56092928377861 0.0613504936446655 no 3163 0.0592702185032926 4560 62616 SGTC_987 1497-1013 404 µM -1.56313834639189 0.0610933596097666 no 3164 0.0590100289315308 4542 1676435 SGTC_2479 5617353 43.85 µM -1.563660123469 0.061032748105993 no 3165 0.0589487035788831 4545 2731746 SGTC_3215 9129942 49.47 µM -1.57461171863101 0.0597713880090496 no 3166 0.0576730481262208 4504 17682944 SGTC_1183 1254-0324 198 µM -1.5746846124515 0.0597630613427831 no 3167 0.0576646306763812 4568 5799357 SGTC_2834 9001755 58.44 µM -1.58054619191435 0.0590964624282362 no 3168 0.056990918623219 4397 2989575 SGTC_721 1187-1332 279 µM -1.58255350000069 0.0588695298041298 no 3169 0.056761634578672 4544 25730 SGTC_398 bronopol 33.3 µM -1.58601453078846 0.0584798557598097 no 3170 0.0563680066817698 4464 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_617 3770-0098 35 µM -1.58832258146293 0.0582211223114792 no 3171 0.0561067068902681 4470 5962639 SGTC_758 0868-0029 16 µM -1.59086510827266 0.0579371458843368 no 3172 0.055819968217038 4490 762687 SGTC_2644 guaiazulene 100 µM -1.59367766539403 0.0576242791073228 no 3173 0.0555041245886277 4575 3515 A coloring agent. SGTC_1465 k213-0056 144 µM -1.59758098077547 0.0571922805870574 no 3174 0.0550681309954442 4465 24048857 YMR208W ERG12 SGTC_712 r015-0009 80.6 µM -1.59831124297531 0.0571117427642418 no 3175 0.0549868632453044 4572 6813872 YLR060W FRS1 SGTC_2717 st081029 62.2815 µM -1.60985744719284 0.0558501853530725 no 3176 0.0537144902521213 4522 5292846 SGTC_1525 8-methoxypsoralen 92.5 µM -1.61330910777355 0.0554773506301321 no 3177 0.0533386844029276 4574 4114 Related to psoralen; DNA damaging agent. SGTC_115 0527-0192 112.043 µM -1.61615609670292 0.0551713112894156 no 3178 0.0530302841320517 4527 4233931 SGTC_3150 9097574 49.47 µM -1.62223771570926 0.0545220306365533 no 3179 0.0523762295027317 4581 17217476 SGTC_22 0964-0034 14.468 µM -1.62581946012013 0.0541424762067495 no 3180 0.0519940336650887 4562 138402 SGTC_1140 3229-1848 2.98 µM -1.62604729156807 0.0541184040154177 no 3181 0.0519697976951404 4554 2849525 SGTC_1417 3966-0327 90.4 µM -1.6273964799688 0.053976025168467 no 3182 0.0518264593263012 4615 651118 SGTC_2127 5253358 187.912 µM -1.63015196524035 0.0536861622063513 no 3183 0.05153469157784 4495 20612 SGTC_2288 7946289 167.31 µM -1.63118892700297 0.0535773989625639 no 3184 0.0514252305228636 4569 1246052 SGTC_1682 st012968 530 nM -1.63562401270013 0.0531141871411559 no 3185 0.0509591507977286 4538 24207270 SGTC_88 0180-0332 8.668 µM -1.64114091588865 0.0525424255154496 no 3186 0.0503840835316772 4624 3101745 SGTC_491 tetrandrine 80.3 µM -1.64254959549494 0.0523972182968933 no 3187 0.0502380783984231 4581 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2967 9089538 49.85 µM -1.64522668814008 0.0521221407988052 no 3188 0.0499615358988968 4550 728216 SGTC_968 1309-0633 340 µM -1.64663984110706 0.0519773993064568 no 3189 0.0498160481203383 4593 3761976 SGTC_2561 acetosyringone 100 µM -1.65068885612267 0.051564448852924 no 3190 0.0494010622394334 4525 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2073 5212005 126 µM -1.65143425045611 0.0514887127605487 no 3191 0.0493249679847299 4503 691789 SGTC_1832 st054113 55 µM -1.65467288621694 0.0511606764995452 no 3192 0.0489954349412103 4587 1251267 SGTC_259 usnic acid 108.925 µM -1.66538502003431 0.0500874950340875 no 3193 0.0479179830439154 4602 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1079 idarubicin 2.36 µM -1.66824300874943 0.0498042251328784 no 3194 0.0476337481457032 4593 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3021 9087658 49.47 µM -1.66902516658801 0.0497269246027073 no 3195 0.047556196181865 4603 25237042 SGTC_720 r052-1644 49.9 µM -1.67380065748593 0.0492570378384986 no 3196 0.0470848915492387 4578 1422863 YOR257W CDC31 SGTC_1403 3909-7815 62.9 µM -1.67582077199735 0.0490593378380834 no 3197 0.0468866520709405 4603 6615483 SGTC_1251 0490-5699 265 µM -1.67690083627682 0.0489538968826255 no 3198 0.0467809373009281 4587 3883818 SGTC_60 0986-0278 202 µM -1.68061938781374 0.0485922585511977 no 3199 0.0464184337546353 4534 3110598 SGTC_1142 3253-1408 9.78 µM -1.68460083793054 0.0482074237311614 no 3200 0.0460328047948145 4587 256655 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.69193423606493 0.047504984610223 no 3201 0.0453292566891617 4636 368090 SGTC_3086 9117350 49.47 µM -1.69362585692167 0.0473441200309162 no 3202 0.0451682007131838 4568 2679265 SGTC_1260 0700-1617 7.75 µM -1.69515862382811 0.0471987388928884 no 3203 0.0450226668298659 4556 2853078 SGTC_2014 4013930 200 µM -1.69527926509227 0.0471873114186274 no 3204 0.0450112281656347 4555 64556 SGTC_3058 9093861 49.47 µM -1.69572794884175 0.0471448303141416 no 3205 0.044968706508009 4595 17217477 SGTC_654 1124-0271 80.9 µM -1.6988408962119 0.0468509419630166 no 3206 0.0446745828499529 4592 5403748 SGTC_1399 3562-5772 25 µM -1.70376027829722 0.0463895088034462 no 3207 0.0442129408300135 4600 23847490 SGTC_9 0092-0002 10.449 µM -1.70680027822258 0.046106188482393 no 3208 0.0439295903553977 4592 759368 SGTC_844 0330-0132 15.3 µM -1.71175708750301 0.0456472085985508 no 3209 0.0434707216387839 4636 2828079 SGTC_272 doxorubicin 8.13 µM -1.7148454946564 0.0453630970844926 no 3210 0.0431867789744548 4623 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2050 5263056 171 µM -1.71933977622213 0.0449521978475391 no 3211 0.0427762606153207 4574 763468 YGL055W OLE1 SGTC_1799 st045822 46.1415 µM -1.72075529619709 0.0448234031195416 no 3212 0.0426476187786474 4578 3674992 SGTC_3048 9093155 49.47 µM -1.72133872712269 0.0447704046972033 no 3213 0.0425946879388611 4595 25236002 SGTC_2003 4023581 200 µM -1.72459705515843 0.0444753477988617 no 3214 0.0423000572614542 4603 16641307 SGTC_2899 9053889 58.44 µM -1.73148518319345 0.0438567522356092 no 3215 0.0416826326511382 4607 6470052 SGTC_3176 9106582 49.47 µM -1.73282846267193 0.0437369300972848 no 3216 0.0415630811485429 4626 17018027 SGTC_1494 4358-1428 177 µM -1.73646525904622 0.0434138486855011 no 3217 0.0412408010095639 4626 1564571 SGTC_1315 1237-0019 3.69 µM -1.73656202236243 0.0434052789256087 no 3218 0.0412322539303423 4611 825140 SGTC_2594 a-mangostin 100 µM -1.73680863048006 0.0433834444652126 no 3219 0.0412104775912237 4593 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_385 1494-0393 12.4 µM -1.73794120961978 0.0432832807861416 no 3220 0.0411105866998827 4563 3090647 SGTC_863 0466-0191 129 µM -1.74052696104384 0.0430553004357173 no 3221 0.0408832650759732 4645 765160 YPR165W RHO1 SGTC_694 1315-0438 43.2 µM -1.74237438303593 0.0428930119669126 no 3222 0.0407214777026622 4633 6793154 SGTC_3090 9117696 49.47 µM -1.75956128509286 0.0414067891712338 no 3223 0.0392411103023994 4580 7923821 SGTC_156 3474-0145 5.642 µM -1.76297535470935 0.0411165874515702 no 3224 0.0389523232034006 4545 2265471 SGTC_1561 5-methoxyflavone 52.9 µM -1.76446988756933 0.0409900696837068 no 3225 0.0388264504013112 4585 94525 SGTC_1058 3448-5425 97.3 µM -1.76462690612645 0.0409767958277811 no 3226 0.0388132452111917 4568 7279705 SGTC_2766 oltipraz 83.91 µM -1.78182675012597 0.0395437501457648 no 3227 0.0373887442920888 4597 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1866 st057638 64 µM -1.78188684872984 0.0395388152923481 no 3228 0.0373838427922327 4632 688802 SGTC_956 1185-0240 191 µM -1.78862739113889 0.0389885023650859 no 3229 0.0368374217643335 4609 1416193 SGTC_892 0929-0076 29 µM -1.80032474851719 0.0380483164156909 no 3230 0.0359046876586654 4629 5751038 SGTC_1714 st033236 13.627 µM -1.80068689067455 0.0380195066803032 no 3231 0.0358761225010348 4610 2916566 SGTC_2946 9065502 71.43 µM -1.80517712962744 0.037663767837485 no 3232 0.0355234842880105 4527 16489101 SGTC_2065 5221596 34.26 µM -1.81158339106077 0.0371609407736773 no 3233 0.035025296591847 4597 788581 SGTC_86 0417-1630 471.922 µM -1.81259150207573 0.0370823160288876 no 3234 0.0349474247296913 4643 3634867 SGTC_1908 st060353 56.5 µM -1.81360946683197 0.0370030607833461 no 3235 0.0348689359674707 4620 4227716 SGTC_2608 thymoquinone 42.66 µM -1.8242182806914 0.0361853078674395 no 3236 0.0340595394881037 4590 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2218 6965428 192.983 µM -1.82497103368177 0.0361278505343202 no 3237 0.0340027003107435 4548 675684 SGTC_1257 0669-0121 16 µM -1.82614462376034 0.0360384199263963 no 3238 0.033914240026948 4625 4307855 SGTC_800 3448-7362 155 µM -1.82796470038805 0.0359000840653593 no 3239 0.0337774248005958 4690 15991913 SGTC_1871 st057448 67.3 µM -1.82970500808709 0.0357682182189773 no 3240 0.0336470308162977 4624 691747 SGTC_332 4112-0506 40.9 µM -1.83050498415155 0.0357077360734854 no 3241 0.0335872310837312 4638 2790355 SGTC_846 0335-0850 148 µM -1.83560277561674 0.0353242839214935 no 3242 0.0332082131820631 4639 6819598 SGTC_889 0919-1524 82.7 µM -1.84167771992786 0.0348717482433943 no 3243 0.0327611525407278 4664 3905452 SGTC_913 3487-1245 167 µM -1.84221151470366 0.0348322132225629 no 3244 0.0327221083945717 4573 4016153 SGTC_1359 1582-0056 520 nM -1.84268290277751 0.0347973309007063 no 3245 0.0326876608637298 4685 3661189 SGTC_1379 2144-0755 36.5 µM -1.86637090745358 0.0330810323117098 no 3246 0.0309947452430121 4658 5392327 SGTC_2536 dehydroabietamide 32.04 µM -1.87133181065294 0.0327305733822263 no 3247 0.0306495519873716 4658 3983547 SGTC_2439 5492030 7.2 µM -1.87243398767632 0.0326531280534625 no 3248 0.0305732932944494 4650 5722370 SGTC_100 0086-0128 49.5915 µM -1.87389843584585 0.0325504613057741 no 3249 0.030472212551062 4634 93297 SGTC_307 1501-1223 22.3 µM -1.87518201578273 0.0324606936228377 no 3250 0.0303838437136941 4662 2830329 SGTC_1086 cerivastatin 2.18 µM -1.87863244177493 0.0322203986631528 no 3251 0.0301473491256991 4656 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2407 paclitaxel 400 µM -1.88063866451249 0.0320813573867957 no 3252 0.0300105442038041 4649 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_412 gemfibrozil 100 µM -1.88733106118811 0.0316211189667911 no 3253 0.0295579055745927 4621 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1407 3909-7909 12.3 µM -1.89012644399328 0.0314305018232957 no 3254 0.029370525602954 4668 4411780 SGTC_2143 5623677 140.463 µM -1.89914837776301 0.0308217666739415 no 3255 0.0287724849297201 4638 5375313 SGTC_1275 0867-0008 21.1 µM -1.90272822081017 0.0305829446160363 no 3256 0.0285380087765746 4648 3422836 SGTC_1630 st005209 31.3 µM -1.90636938211508 0.0303416061364826 no 3257 0.0283011491200553 4658 3367314 SGTC_2866 9034245 58.44 µM -1.90659878616178 0.03032645408601 no 3258 0.0282862812050479 4682 6462273 SGTC_1187 1391-0724 117 µM -1.9149171942548 0.0297812479652663 no 3259 0.0277515323312269 4688 6997986 SGTC_2243 6634756 200 µM -1.91576458670486 0.0297261673394872 no 3260 0.0276975336236841 4661 885676 SGTC_1284 0929-0043 16 µM -1.91817381766994 0.0295700286130437 no 3261 0.0275444874711347 4663 1239883 SGTC_467 ro 31-8220 72.8 µM -1.91824822365828 0.0295652173268772 no 3262 0.0275397720834589 4645 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_891 0929-0073 133 µM -1.93275892314651 0.0286392595795159 no 3263 0.0266329513641076 4684 5603632 SGTC_1215 3852-0577 11.2 µM -1.93406496639758 0.0285571145643373 no 3264 0.0265525703332455 4679 2884876 SGTC_3004 9076122 71.4286 µM -1.93562859917827 0.0284590260502428 no 3265 0.0264566025246171 4654 44782551 SGTC_886 0866-0150 153 µM -1.9457830857329 0.027828822419961 no 3266 0.0258404006179357 4689 271463 SGTC_1948 st076329 66.6 µM -1.95116457481098 0.0274995797749548 no 3267 0.0255187357879118 4600 24208413 SGTC_616 4092-0450 108 µM -1.95237416532365 0.0274260250552733 no 3268 0.0254468989819086 4685 787165 SGTC_1242 0402-0103 60.1 µM -1.95390033398835 0.0273334534939858 no 3269 0.0253565025392925 4605 432868 SGTC_1828 st055811 49 µM -1.96594958990973 0.0266117042570511 no 3270 0.0246522169685439 4671 5877589 SGTC_796 1234-0020 70.7 µM -1.96635465411483 0.0265877202256314 no 3271 0.0246288288067385 4638 46495034 SGTC_2843 9000894 45.46 µM -1.98231316866736 0.0256570804659474 no 3272 0.0237221005353633 4703 2242070 SGTC_3260 9137109 49.47 µM -1.98977735223647 0.0252312485002122 no 3273 0.0233077336616636 4687 17478346 SGTC_1531 st059297 52.4 µM -1.99402824178016 0.0249913929303404 no 3274 0.0230744841212738 4686 7566702 SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.00195894580091 0.0245490138832994 no 3275 0.0226445735568132 4670 6708630 An antioxidant. SGTC_2550 chrysin dimethyl ether 71.87 µM -2.00871220073063 0.0241775119461438 no 3276 0.0222838320309895 4602 88881 An O-methylated flavonoid and antioxidant. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.00972837473249 0.0241220222404505 no 3277 0.0222299725532722 4658 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1882 5615643 20 µM -2.01153288211747 0.0240237480820495 no 3278 0.0221346003625364 4690 2253075 SGTC_1475 4092-1048 11.7 µM -2.01175012808873 0.0240119395040902 no 3279 0.0221231417581798 4685 2881759 SGTC_939 1165-0479 45.3 µM -2.01787037948857 0.023681267078702 no 3280 0.0218023813298014 4672 1377347 SGTC_1812 st052057 4.327 µM -2.02521453162288 0.0232895309407758 no 3281 0.0214226700775937 4718 3645418 SGTC_2670 beta-carotene 100 µM -2.02675803809447 0.0232078978517427 no 3282 0.0213435818844656 4708 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_911 3456-4043 236 µM -2.02963405237047 0.0230564335026179 no 3283 0.0211968754385548 4664 914281 SGTC_2107 5363541 170.161 µM -2.03185029407814 0.0229402845377894 no 3284 0.0210844069214137 4642 244052 SGTC_1137 ixabepilone 100 µM -2.03373587567078 0.0228418532609046 no 3285 0.0209891164655452 4652 154225 A novel microtubule stabilizer. SGTC_247 mechlorethamine 29.705 µM -2.04010614597653 0.0225119399073884 no 3286 0.0206698773594125 4694 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1974 st069448 26.9 µM -2.04127892498007 0.022451642269015 no 3287 0.020611555319554 4684 6323587 YNR016C ACC1 SGTC_852 0418-0143 439 µM -2.04790929747052 0.0221133022001187 no 3288 0.0202844438439693 4680 5369229 SGTC_2751 anetholtrithion 17.25 µM -2.05550307261605 0.0217310975082223 no 3289 0.0199152195971948 4651 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2914 7968218 45.32 µM -2.06090008903292 0.0214628638922486 no 3290 0.0196562864044834 4683 2977111 SGTC_567 1080-0542 68.4 µM -2.06473217344478 0.0212741116219193 no 3291 0.0194741743047802 4618 5950415 SGTC_3265 9137266 49.47 µM -2.07144429349661 0.0209468836735874 no 3292 0.0191586476124312 4680 17224265 SGTC_996 3970-0799 1.8 µM -2.07686720154151 0.0206856277502251 no 3293 0.0189069088303899 4653 6615648 YGL040C HEM2 SGTC_2192 5915882 198.485 µM -2.07888091144986 0.020589319725009 no 3294 0.0188141488078531 4716 2876149 SGTC_2061 5245884 80.95 µM -2.0870439599931 0.0202027940427651 no 3295 0.0184420805015527 4679 573863 SGTC_1885 st057546 99.9 µM -2.08762913892102 0.0201753233571221 no 3296 0.0184156506994893 4711 702008 SGTC_2941 9056145 11.23 µM -2.08888334569971 0.0201165524565584 no 3297 0.0183591126856526 4673 2119517 SGTC_1252 0493-0875 34.8 µM -2.10503530370347 0.0193725716389876 no 3298 0.0176441175424385 4679 3960963 SGTC_1634 st006576 41 µM -2.10784440733107 0.019245596731331 no 3299 0.0175222251188184 4673 3915356 SGTC_2393 9031399 185.94 µM -2.10785610951014 0.0192450692616192 no 3300 0.0175217188461171 4681 1526623 YDL150W RPC53 SGTC_2324 6149169 200 µM -2.12058109384965 0.0186787213646099 no 3301 0.0169785352699215 4703 2888231 SGTC_1132 3456-3614 2.5 µM -2.12921910486868 0.018302407374267 no 3302 0.016618068487859 4673 3125502 SGTC_2010 4012422 159 µM -2.14769616508083 0.017519096464834 no 3303 0.0158689501119425 4678 952393 SGTC_3014 9081533 49.47 µM -2.1754304216869 0.0163971382618364 no 3304 0.0147989384255882 4719 21367265 SGTC_871 0574-0004 149 µM -2.18942348373617 0.0158548068117187 no 3305 0.0142830371696173 4694 9551173 SGTC_940 3232-1287 54.8 µM -2.19946794987619 0.0154750604352793 no 3306 0.0139223328246931 4713 1585493 YIL048W NEO1 SGTC_3261 9137475 49.47 µM -2.19965694327354 0.0154679907438002 no 3307 0.0139156219045336 4746 17027690 SGTC_1030 k029-0042 36.7 µM -2.20469784037659 0.0152804460374398 no 3308 0.0137376523930241 4710 6080581 SGTC_318 1488-0629 67.2 µM -2.20580235392795 0.0152396148726866 no 3309 0.0136989207095432 4749 3662576 SGTC_593 1203-0218 61.7 µM -2.21012617290655 0.015080674162081 no 3310 0.0135482034384769 4754 3666956 SGTC_715 0868-0130 184 µM -2.21642677977697 0.0148516193263167 no 3311 0.013331143664586 4760 2876258 SGTC_1912 st060209 90.8 µM -2.22142815300918 0.0146719333213267 no 3312 0.0131609879806642 4690 688787 SGTC_61 0978-8327 98.565 µM -2.22684895536149 0.0144792936539121 no 3313 0.0129786851399851 4691 6150059 YHR072W ERG7 SGTC_865 0488-0499 301 µM -2.22916164294143 0.0143977723633368 no 3314 0.0129015758222841 4684 9634651 SGTC_2902 5787006 60.46 µM -2.25434773308974 0.0135352571030741 no 3315 0.0120871503202446 4725 591003 SGTC_2027 5150920 200 µM -2.27593550752955 0.0128318330173633 no 3316 0.0114249349525788 4721 786715 SGTC_2948 9070189 9.45 µM -2.31438028812312 0.0116572361268774 no 3317 0.0103234355914934 4695 6473636 YDL196W YDL196W SGTC_90 0870-0863 4.608 µM -2.31771620359421 0.0115598612816285 no 3318 0.0102323749042966 4757 1738164 SGTC_676 falcarinol 140 µM -2.32696183034466 0.0112936658408884 no 3319 0.0099836484303681 4740 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_910 3454-3003 490 µM -2.339225411873 0.0109488092056857 no 3320 0.0096618852899866 4677 820824 SGTC_1973 st070275 50.2 µM -2.36452003945945 0.0102663451879213 no 3321 0.0090267253094556 4751 17118334 SGTC_2555 cholic acid 100 µM -2.36612041862597 0.0102244419172732 no 3322 0.00898779831622343 4727 6708657 Influences liver metabolism. SGTC_1921 5740136 50 µM -2.37350703627319 0.0100329630530984 no 3323 0.00881002866367084 4706 1774243 SGTC_1997 st073024 93.8 µM -2.38834008913469 0.00965788706745487 no 3324 0.00846233596760319 4774 686268 SGTC_867 0518-0118 155 µM -2.38888650409556 0.00964430732789148 no 3325 0.00844976105867532 4741 6848158 SGTC_1991 st073000 8.92 µM -2.40518076906761 0.00924695114699968 no 3326 0.0080822338616629 4756 4301969 YIL048W NEO1 SGTC_2193 5925765 200 µM -2.42499554044862 0.00878310642477154 no 3327 0.0076542874021027 4767 877370 SGTC_19 0279-0214 38.434 µM -2.43460547861858 0.00856558484288629 no 3328 0.00745401706353301 4785 3566274 YBR002C RER2 SGTC_1346 1488-2224 62.4 µM -2.43506952641251 0.00855520176701224 no 3329 0.0074444642833548 4752 3722427 SGTC_2693 st077581 40.7 µM -2.45825635074739 0.0080502590121056 no 3330 0.0069806738169647 4719 25238761 SGTC_1913 st060213 96.1 µM -2.47433923758529 0.00771558806868725 no 3331 0.00667414404227557 4734 688959 SGTC_882 0843-0131 351 µM -2.51006749476298 0.00701560263408494 no 3332 0.00603540437741096 4772 5425421 SGTC_3337 9144342 33.5465 µM -2.51242246778162 0.00697149817652191 no 3333 0.00599527247600458 4754 17682949 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.54077955496676 0.00645932760746936 no 3334 0.00553028160827136 4772 2724278 An inhibitor of dopamine biosynthesis. SGTC_141 0443-0274 32.331 µM -2.54465088218778 0.00639205304243391 no 3335 0.00546935212297593 4725 1627241 SGTC_2032 5185112 25.99 µM -2.56096093077587 0.00611538364102489 no 3336 0.00521915470190197 4733 5718189 SGTC_946 3434-1334 87.4 µM -2.58439032026578 0.00573651982414043 no 3337 0.00487756630005451 4745 4047976 SGTC_470 aa-861 153 µM -2.61596767971137 0.00525890874359084 no 3338 0.00444874896076699 4752 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_711 k292-0785 179 µM -2.62357838601585 0.00514922427640644 no 3339 0.00435057102487908 4730 4146315 SGTC_2421 5690543 90.72 µM -2.62665055796688 0.00510552854675813 no 3340 0.00431149180540757 4727 3397993 SGTC_2430 5571206 200 µM -2.63090991552346 0.00504549352119607 no 3341 0.00425783025232093 4744 1731771 SGTC_2898 9056270 58.44 µM -2.65445751960196 0.00472480046096456 no 3342 0.00397180204083378 4784 19154699 SGTC_1270 0831-1170 17.3 µM -2.69658451003239 0.00419615746973089 no 3343 0.00350273095163306 4782 6764716 SGTC_1698 5-fluorocytosine 1.055 µM -2.77772436596125 0.00332471941890611 no 3344 0.00273705162906855 4786 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1375 2910-0797 186 µM -2.7947533882692 0.00316394547587573 no 3345 0.00259696598153372 4783 742508 SGTC_2196 6573537 42.6665 µM -2.87615985743083 0.00248795356284438 no 3346 0.00201272894332082 4791 2903087 SGTC_389 tpck 16.7 µM -2.87895156898381 0.00246728285003329 no 3347 0.00199499801395798 4781 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1805 st050013 60.3 µM -3.01946135017133 0.00160735774006506 no 3348 0.00126612300103393 4776 4037144 SGTC_669 0108-0021 26.2 µM -3.11355939745404 0.00119499663368269 no 3349 0.000924226496188738 4771 17201 SGTC_3354 9151612 71.43 µM -3.19677264660488 0.000913598679608328 yes 3350 0.000694872088271604 4790 27261949 SGTC_184 1494-0393 24.714 µM -3.47893194460714 0.000351552455548262 yes 3351 0.000251708207298372 4781 3090647 SGTC_1926 methyl fluorone black 53.6 µM -3.4878171284585 0.00034075469928541 yes 3352 0.000243490514875951 4691 72721 Reacts with homocysteine. SGTC_2335 9018011 154.17 µM -3.61119216675796 0.000219397261696846 yes 3353 0.00015239635531287 4802 6458208 SGTC_66 0109-0187 42.4 µM -3.64347524904247 0.000195094989610398 yes 3354 0.00013449076428154 4746 759417 SGTC_1923 st058458 19.1 µM -4.55103734144241 4.94487727713133e-06 yes 3355 2.66910360323863e-06 4806 3534982 SGTC_1935 st074532 41.6 µM -5.06418046976884 4.48154231035187e-07 yes 3356 2.050804790004e-07 4809 2829742