SGTCid condition conc unit SFL1|YOR140W.score SFL1|YOR140W.strain.pval SFL1|YOR140W.strain.significant SFL1|YOR140W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 6.15026956124098 2.87874606549036e-10 yes 1 3.86756840480076e-10 12 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1030 k029-0042 36.7 µM 5.80590902044869 2.44578420116312e-09 yes 2 3.20088593316259e-09 6 6080581
SGTC_2318 6029776 164 µM 5.47797467356835 1.6832867093498e-08 yes 3 2.15110845722987e-08 9 818325
SGTC_2071 5230951 39.92 µM 5.27696807907226 5.21151512559755e-08 yes 4 6.56693767596802e-08 3 1799272
SGTC_580 1123-0028 41 µM 5.08587286250212 1.47101407299236e-07 yes 5 1.82969569057214e-07 11 1677248 YPR107C YTH1
SGTC_887 0885-0007 9.62 µM 4.76949653514185 7.57909568212068e-07 yes 6 9.23434598346846e-07 23 5719458
SGTC_1767 st044992 70.3 µM 4.58935737630829 1.84532167612993e-06 yes 7 2.22306330339988e-06 12 9600693
SGTC_2587 piperic acid 92.2 µM 4.37954284254593 4.9993170000409e-06 yes 8 5.94642697093978e-06 16 5370536
SGTC_1237 0330-0133 46.1 µM 4.1692613005234 1.30049902932178e-05 yes 9 1.52794238564666e-05 20 X1237 YHR072W ERG7
SGTC_917 harmaline 728.087 nM 4.14601047409242 1.44170966329117e-05 yes 10 1.6915917844202e-05 23 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2985 9022375 71.43 µM 4.02379653410708 2.45733378923444e-05 yes 11 2.86336988090958e-05 28 4939335
SGTC_1048 3161-0300 24.5 µM 4.00076001770652 2.71278715120475e-05 yes 12 3.15696829529678e-05 22 2165101
SGTC_1616 st002734 56.1 µM 3.91034593286347 3.97967020425971e-05 yes 13 4.60820156291589e-05 32 4026101
SGTC_2342 7990637 118.86 µM 3.83870030985522 5.36172085462024e-05 yes 14 6.18436434696138e-05 40 2033102 YER133W GLC7
SGTC_855 0428-0020 25 µM 3.73432301426142 8.20488677439333e-05 yes 15 9.41103987267522e-05 27 6812414
SGTC_1867 st057372 64 µM 3.711339829206 8.99803553877783e-05 yes 16 0.000103082552166888 12 688837
SGTC_1680 diphenhydramine 100 µM 3.70975931137058 9.05514749092286e-05 yes 17 0.000103728188784599 36 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1827 berberine 7.24 µM 3.6408861325286 0.000119021831045246 yes 18 0.000135850644719618 25 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_668 1682-0499 62.6 µM 3.50231918051296 0.000203486511806749 yes 19 0.000230613364125166 39 682214
SGTC_1703 st026983 48.3 µM 3.49311232093633 0.000210731228455344 yes 20 0.000238712824985149 19 1104023
SGTC_1843 st055809 45.5 µM 3.46624976563056 0.000233269131486296 yes 21 0.000263886377366139 31 16413835
SGTC_2144 5628481 200 µM 3.42591579876915 0.000271365824470208 yes 22 0.00030636514888511 43 2818399
SGTC_3003 9075612 71.4286 µM 3.36981165579594 0.000334058300841147 yes 23 0.00037609788735462 38 6501993
SGTC_26 0302-0163 425.158 µM 3.34971166035757 0.000359621289111181 yes 24 0.000404478614983735 22 3100915
SGTC_907 3448-6986 75.5 µM 3.33515496543578 0.000379256412251361 yes 25 0.000426259382260632 47 590582
SGTC_1875 nocodazole 6 µM 3.33213389696791 0.000383454224411653 yes 26 0.000430913901192288 63 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1958 st076513 41.9 µM 3.26849961198928 0.000482542639487163 yes 27 0.000540596628664763 62 732122 YGL099W LSG1
SGTC_2236 dapsone 200 µM 3.20768951306959 0.000598922073585274 yes 28 0.00066902934775242 23 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1878 temozolomide 1 mM 3.1151145977055 0.00082661730403502 yes 29 0.000919367292999622 34 5394 DNA alkylating agent.
SGTC_800 3448-7362 155 µM 3.11007434435538 0.000841051034686073 yes 30 0.000935201302400555 256 15991913
SGTC_3029 9088683 49.47 µM 3.0359959138032 0.00108172148411637 no 31 0.0011987130668653 57 25236615
SGTC_2856 9022925 19.48 µM 3.00274689983616 0.00120903970819058 no 32 0.00133777422616001 75 4944862
SGTC_932 2857-0803 154 µM 2.98841060252664 0.00126805500919022 no 33 0.00140216263270548 69 674898
SGTC_2963 9082507 9 µM 2.97741009611935 0.00131511226314943 no 34 0.00145347443548714 70 16459611
SGTC_1696 st025591 34.7925 µM 2.9579205646525 0.00140242045653421 no 35 0.00154860963352864 72 2787147
SGTC_3265 9137266 49.47 µM 2.95314839991683 0.00142459017580596 no 36 0.0015727535410716 39 17224265
SGTC_1738 st035555 74 µM 2.9495447682076 0.00144154285340943 no 37 0.00159121231359977 84 5331140
SGTC_735 3076-0345 636 µM 2.94123751367956 0.0014813267132225 no 38 0.00163451884661258 93 2888990
SGTC_2065 5221596 34.26 µM 2.93888063320201 0.00149279497418688 no 39 0.00164699955034838 58 788581
SGTC_1294 1000-1494 117 µM 2.93667640286225 0.00150359370411184 no 40 0.00165875039796674 70 712797 YDL207W GLE1
SGTC_2623 humulene 100 µM 2.92173918215373 0.00157867027899404 no 41 0.00174041447418471 63 6187145 An anti-inflammatory.
SGTC_1155 4088-0394 48.2 µM 2.89535605801257 0.00171967124880968 no 42 0.00189364339524594 79 2326248
SGTC_2793 7325131 81.82 µM 2.87606804908958 0.00182990519185654 no 43 0.00201331446556205 55 4176441
SGTC_1203 3992-3522 103 µM 2.86009484362373 0.00192601651769325 no 44 0.00211757163504841 98 5322312
SGTC_1191 1487-1166 10.6 µM 2.84924335313843 0.00199390254727768 no 45 0.00219116732282628 84 3955771
SGTC_1040 k898-0338 155 µM 2.82696754387633 0.00214011009432159 no 46 0.0023495545175517 73 20969351
SGTC_1051 3253-3903 78 µM 2.81552018311611 0.00221896689361142 no 47 0.00243491689663016 85 5509239
SGTC_2845 9003024 42.97 µM 2.78963475886627 0.0024070765671377 no 48 0.00263837658628526 125 2990173
SGTC_572 0960-0087 17.7 µM 2.78261314059327 0.00246053237830697 no 49 0.00269615302286451 109 6796365
SGTC_1427 4048-4900 550 nM 2.78183980269365 0.00246648499209529 no 50 0.0027025856668286 80 24132586
SGTC_1745 st081495 74 µM 2.77102751262102 0.00255108552849144 no 51 0.00279398525315292 179 13842402 YBL026W LSM2
SGTC_2781 5567276 71.43 µM 2.76470005718145 0.00260180270948634 no 52 0.00284875790759522 132 2853274
SGTC_1298 1079-1278 263 µM 2.74050477476937 0.00280424791395343 no 53 0.00306724453277658 75 2840950
SGTC_1712 st032288 53.4 µM 2.74034778115507 0.00280560666592753 no 54 0.00306871018231082 304 2883011
SGTC_2741 miltefosine 3.04 µM 2.72911737274455 0.00290435860885358 no 55 0.00317520483708269 80 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2185 6113692 200 µM 2.7227208142028 0.00296199576934195 no 56 0.00323733740997708 72 874150
SGTC_2460 5552655 174.22 µM 2.70162057449278 0.00315950371666704 no 57 0.0034501228023659 106 5401989
SGTC_3341 9147222 25.867 µM 2.69039366128947 0.0032693545811381 no 58 0.00356838880376759 68 1939759
SGTC_454 lyso-paf C-16 6.67 µM 2.67847264194585 0.00338974620216487 no 59 0.00369793868553813 95 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.66915858945744 0.00348656643126663 no 60 0.00380207682477659 88 5393153
SGTC_3303 9125618 40.5795 µM 2.66106569943315 0.0035727015233552 no 61 0.00389468782524698 156 22695467
SGTC_2843 9000894 45.46 µM 2.65136282658509 0.00367848704176997 no 62 0.00400838350528497 46 2242070
SGTC_1217 1183-1422 255 µM 2.62435286341078 0.00398791642084071 no 63 0.00434068964380508 83 2849664
SGTC_2376 9072922 81.32 µM 2.61697881303771 0.00407634952829896 no 64 0.00443559237203547 134 17087968
SGTC_1866 st057638 64 µM 2.60974823731801 0.00416476220687543 no 65 0.00453044398008895 83 688802
SGTC_625 k213-0058 121 µM 2.57712264327125 0.00458539565304069 no 66 0.00498132976166977 270 3655420
SGTC_2777 climbazole 1.536 µM 2.56225153444145 0.00478940699549149 no 67 0.00519979847922715 144 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1013 4112-3890 241 µM 2.5483624756861 0.00498721487566177 no 68 0.00541149751757556 130 705171
SGTC_1621 st003705 32.4 µM 2.54491893152667 0.00503736995390528 no 69 0.00546515555334929 134 24207032
SGTC_2700 st077718 96.8 µM 2.52604465368904 0.00532033305784521 no 70 0.00576774090621059 73 904970
SGTC_2839 9003951 25.97 µM 2.52434057697144 0.00534656339704879 no 71 0.00579577838023874 78 2990634
SGTC_1600 coumarin 106 71.1 µM 2.5189248055471 0.00543069182494626 no 72 0.00588568961567473 127 100336 A hepatotoxic, DNA x-linker.
SGTC_263 alizarin 107.927 µM 2.50111678469883 0.0057156763836091 no 73 0.00619011729343216 202 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1174 0739-0097 51.1 µM 2.49351409166871 0.00584133387045595 no 74 0.00632427817507236 139 728447
SGTC_1407 3909-7909 12.3 µM 2.49049603052484 0.00589189209828141 no 75 0.0063782460375858 98 4411780
SGTC_1324 1418-0026 34.4 µM 2.48536592218577 0.0059787221252695 no 76 0.00647091642192146 103 1372513
SGTC_3091 9116372 49.47 µM 2.4830448703064 0.00601837865431122 no 77 0.0065132338985761 122 17169793
SGTC_2265 7929201 200 µM 2.48187789664977 0.00603840502820143 no 78 0.00653460252001253 123 1265108
SGTC_1479 0549-0158 134 µM 2.47552661003543 0.00614843804171987 no 79 0.00665199236097271 145 5440202
SGTC_2315 7733312 200 µM 2.47104022751847 0.00622722936076697 no 80 0.00673603315330519 119 726316
SGTC_1787 fluconazole 80 µM 2.46025825869653 0.00642025345557863 no 81 0.00694185344949534 175 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_656 4090-1979 187 µM 2.45721750030488 0.00647563912022257 no 82 0.0070008943046642 137 22330961
SGTC_1081 sertraline 6 µM 2.44365250866661 0.00672789912527228 no 83 0.00726971150337476 133 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1521 st012942 49.4 µM 2.44105015775405 0.00677727428008054 no 84 0.00732231030638436 153 24207259
SGTC_663 1486-0733 13.9 µM 2.43137853606955 0.00696359398362172 no 85 0.00752074534920244 176 722445 YPR165W RHO1
SGTC_2382 9035899 200 µM 2.42674773020797 0.00705439475867872 no 86 0.00761742260557997 112 6462679
SGTC_296 1222-0039 74.9 µM 2.42389636965184 0.0071108225128425 no 87 0.00767749324210626 110 5984176
SGTC_3349 9149703 23.001 µM 2.42232056102282 0.00714217794050488 no 88 0.00771086995667288 102 4910494
SGTC_744 1594-0068 283 µM 2.41769309614367 0.00723496130153302 no 89 0.00780962216135772 156 668392
SGTC_689 0833-0039 98 µM 2.40204757218578 0.00755658261593811 no 90 0.00815179402311896 124 5374726
SGTC_157 1348-1695 65.819 µM 2.39260709740538 0.00775668183697781 no 91 0.00836457247073505 204 5380510
SGTC_2387 9077560 195.08 µM 2.35985444623184 0.00848751187554348 no 92 0.00914105332045857 130 5303272
SGTC_136 0097-0015 404.482 µM 2.35395404781989 0.00862540940148247 no 93 0.00928745358588541 153 4861337
SGTC_1071 trifluoperazine 6.31 µM 2.35182254618568 0.00867570549476386 no 94 0.0093408424752138 143 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_315 k915-0449 187 µM 2.33656070737638 0.00904340567587655 no 95 0.00973101877881265 199 20970215 YNL149C PGA2
SGTC_1188 1403-0014 4.57 µM 2.32972892092298 0.00921237738816163 no 96 0.00991024148918757 216 9614867
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.32582821839357 0.00931008818480604 no 97 0.0100138583105511 159 5106787 A p450 inhibitor.
SGTC_977 1348-1378 135 µM 2.32200523528268 0.00940673078806004 no 98 0.0101163268670741 151 X977
SGTC_1862 st057513 3.81 µM 2.30663851088597 0.00980409835609197 no 99 0.0105374903827091 116 5393163
SGTC_1286 0929-0070 131 µM 2.29681778437591 0.0100656635595675 no 100 0.010814583298761 167 1420408
SGTC_1359 1582-0056 520 nM 2.29617787045891 0.0100829164139664 no 101 0.0108328566552003 165 3661189
SGTC_884 0851-0618 334 µM 2.29571187664313 0.0100954964041427 no 102 0.0108461804622315 154 9642473
SGTC_1638 st008370 60.6 µM 2.29419508934384 0.0101365385495053 no 103 0.0108896476300082 175 24207134
SGTC_2565 isoliquiritigenin 100 µM 2.28714274783198 0.0103292826769616 no 104 0.0110937462260313 158 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_370 0180-0345 38.7 µM 2.25213056615534 0.0113342218806582 no 105 0.0121570111050581 132 3989527
SGTC_1506 4226-2149 212 µM 2.24429415591841 0.0115704453125355 no 106 0.0124067406623155 193 991114
SGTC_1514 1189-1591 158 µM 2.24308527435325 0.0116072642928926 no 107 0.0124456580380687 208 767698 YMR146C TIF34
SGTC_902 1120-0002 2.07 µM 2.24165815289398 0.0116508611156064 no 108 0.0124917372118706 199 3280475
SGTC_1713 st033146 12.748 µM 2.21958783669282 0.0123434022251909 no 109 0.0132233793460619 181 674619
SGTC_784 4579-0127 173 µM 2.1944026923157 0.0131769877577426 no 110 0.0141032362670642 165 1948547
SGTC_21 0849-0113 22.993 µM 2.18414316866942 0.013530255637206 no 111 0.0144758647163624 210 1560156
SGTC_120 rhodamine 6G 52.259 µM 2.17132153892777 0.0139832127681478 no 112 0.014953437629869 230 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_249 wiskostatin 11.211 µM 2.16773912635315 0.0141120838550014 no 113 0.0150892703694492 146 2775510 A n-wasp and actin depolymerizer.
SGTC_1242 0402-0103 60.1 µM 2.16325538436268 0.01427481972953 no 114 0.0152607712872615 164 432868
SGTC_529 4076-0302 30.3 µM 2.1592496127657 0.0144215723577384 no 115 0.0154154034633547 175 5816522
SGTC_1454 4239-0054 42.6 µM 2.13920246014215 0.0151756761969616 no 116 0.0162096375203769 221 1340767
SGTC_2847 9005661 71.43 µM 2.12468762793738 0.0157425967567414 no 117 0.0168063432448287 90 2991449
SGTC_1824 st053723 68.6 µM 2.1243346343251 0.0157566072669882 no 118 0.0168210857919199 196 675225
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.12299875915551 0.0158097257522445 no 119 0.0168769779185124 179 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_659 k018-0002 107 µM 2.11882735272404 0.0159765832569486 no 120 0.0170525301193526 186 6797879 YHR007C ERG11
SGTC_725 1497-0963 19 µM 2.11192591064339 0.0162559579923897 no 121 0.0173464022908094 161 3549977
SGTC_1770 st043884 66.3 µM 2.10482924573793 0.0165475889139246 no 122 0.017653087213887 180 670149
SGTC_230 MPP+ 141.667 µM 2.10101914100856 0.0167060009956615 no 123 0.0178196430176606 188 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3024 9090631 49.47 µM 2.10010269647552 0.0167442968442998 no 124 0.0178599040895712 121 25236383
SGTC_3144 9087057 49.47 µM 2.09825157201498 0.0168218796390608 no 125 0.0179414640273356 181 17249618
SGTC_1005 4092-0690 4.4 µM 2.09351173857013 0.0170219343801854 no 126 0.0181517486506167 188 1529343
SGTC_3329 9141233 27.5565 µM 2.08749390423469 0.017278857118618 no 127 0.0184217557513513 179 4909101 YNL103W MET4
SGTC_1667 st014849 34.6 µM 2.07902297897087 0.0176461197382193 no 128 0.0188076192233066 161 5348460
SGTC_227 fluconazole 33.516 µM 2.07466516585581 0.0178376369300802 no 129 0.0190087889713607 273 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_156 3474-0145 5.642 µM 2.06096039416638 0.0184515305422569 no 130 0.0196534093645374 240 2265471
SGTC_2970 9090938 41.86 µM 2.05996985507004 0.0184965898646335 no 131 0.019700711368954 298 17217104
SGTC_1509 1326-1131 80 µM 2.05575094642407 0.0186895576408974 no 132 0.0199032642331471 162 768313
SGTC_2955 9076254 12.21 µM 2.04466764410682 0.0192046752533453 no 133 0.0204438178031991 177 16459619
SGTC_1788 fluconazole 20 µM 2.03807753912587 0.0195166470474888 no 134 0.0207710895078072 241 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2343 7990716 14.84 µM 2.0263679320552 0.0200815950915932 no 135 0.0213635472952991 200 6456862
SGTC_1837 st055472 66.5 µM 2.0214879604509 0.0203210991531248 no 136 0.0216146387046011 221 676091
SGTC_1949 st076024 69.1 µM 2.0173091590909 0.0205281107625101 no 137 0.0218316302004497 222 2921930
SGTC_288 1315-0019 35.1 µM 2.01729134449706 0.0205289970814343 no 138 0.0218325591780185 224 6811474
SGTC_2372 9071633 200 µM 2.01513506127316 0.0206365170900278 no 139 0.0219452497216072 188 21321366
SGTC_2184 6075246 200 µM 2.00888845729694 0.0209506910694651 no 140 0.0222744821577449 212 2267320
SGTC_1036 k216-0215 33.5 µM 1.98230073764256 0.0223335815482659 no 141 0.0237227957646258 279 622330
SGTC_910 3454-3003 490 µM 1.97079514704965 0.0229554621171852 no 142 0.0243736560150629 258 820824
SGTC_3090 9117696 49.47 µM 1.96836213376856 0.023088818937748 no 143 0.024513192759572 192 7923821
SGTC_1822 st052468 42 µM 1.9642813189111 0.023313958632821 no 144 0.0247487384378046 188 2873678
SGTC_199 4063-0024 41.6 µM 1.96124776574795 0.0234825153957666 no 145 0.0249250636539257 185 306215
SGTC_2576 guaiol 23.12 µM 1.95702458509724 0.0237188789977801 no 146 0.0251722889698107 243 227829
SGTC_2804 7954240 19.48 µM 1.95548139352671 0.0238057461624481 no 147 0.0252631387038577 257 828705
SGTC_1024 4507-0395 26 µM 1.95461549608811 0.0238546050696026 no 148 0.025314235449778 226 4201836
SGTC_3002 9075603 71.4286 µM 1.95189979022975 0.024008387852717 no 149 0.0254750516026456 241 20105405
SGTC_310 1273-0058 1.06 µM 1.94827043988689 0.0242152075755889 no 150 0.0256913061058042 552 2734232
SGTC_2233 sulbentine 40.3845 µM 1.94458762067528 0.0244266017698954 no 151 0.025912315207702 301 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2167 5876490 200 µM 1.93783901454723 0.0248179932779871 no 152 0.0263214331209019 244 686534
SGTC_2852 9023854 51.95 µM 1.93766540491759 0.0248281309219094 no 153 0.0263320286160848 229 19798528
SGTC_1930 st074634 34.3 µM 1.93188175072368 0.0251678481582405 no 154 0.0266870513643595 257 684253 YOR116C RPO31
SGTC_1522 st012842 45.6 µM 1.93149883105677 0.0251904767234343 no 155 0.0267106968688936 243 3491067 YOR116C RPO31
SGTC_2324 6149169 200 µM 1.93006998545878 0.0252750646469372 no 156 0.0267990834010053 211 2888231
SGTC_597 k018-0003 82.8 µM 1.92758997305511 0.0254224468263336 no 157 0.026953073523411 235 6786234
SGTC_836 0330-0104 1.35 µM 1.92203088215018 0.0257554290530141 no 158 0.0273009360023457 226 46494820
SGTC_1677 st019204 53.9 µM 1.91035556111425 0.0264666587686381 no 159 0.0280437242370474 246 3945625
SGTC_404 fumagillin 50 µM 1.90930938141645 0.0265311828307913 no 160 0.0281110964039373 259 12015870 A methionine aminopeptidase binder.
SGTC_3278 9139605 49.47 µM 1.90689216657394 0.026680769483701 no 161 0.0282672763890175 239 7958859
SGTC_1759 st043059 70 µM 1.90020572453219 0.0270982258609259 no 162 0.0287030636711338 253 669426
SGTC_451 chloral hydrate 100 µM 1.89506217751746 0.0274230510219897 no 163 0.0290420823579053 339 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1507 4075-3230 155 µM 1.89259200291763 0.0275801977473452 no 164 0.0292060740413607 179 659771
SGTC_192 3455-0609 60.9 µM 1.89051115579458 0.0277131582241117 no 165 0.0293448150022404 235 3769639
SGTC_1137 ixabepilone 100 µM 1.88941416707465 0.0277834675782677 no 166 0.0294181770207373 297 154225 A novel microtubule stabilizer.
SGTC_528 3492-0019 172 µM 1.88881691914082 0.0278218094667426 no 167 0.0294581824455045 523 2869262
SGTC_3125 9127534 49.47 µM 1.8850743071156 0.0280630811159077 no 168 0.0297099031448369 169 1639235
SGTC_695 3505-6186 243 µM 1.87620610448301 0.0286417414829669 no 169 0.0303134920876842 238 1819379
SGTC_1962 st076595 64.5 µM 1.87167884990553 0.0289409552374485 no 170 0.0306255236640698 277 279619
SGTC_1557 sumaresinolic acid 42.3 µM 1.8681063151915 0.029178899872184 no 171 0.0308736267393747 253 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2391 6285546 200 µM 1.86556079966266 0.0293494307092269 no 172 0.0310514191871082 296 846083
SGTC_3129 9127257 49.47 µM 1.8574126931374 0.0299008671677407 no 173 0.0316262309875509 245 837894
SGTC_1173 0443-0020 122 µM 1.85682062528005 0.0299412690213141 no 174 0.0316683391503169 281 5331295
SGTC_1664 st014217 9.02 µM 1.85673502811055 0.0299471137924719 no 175 0.0316744306952592 262 3982782
SGTC_786 4544-0069 423 µM 1.85227101027868 0.0302532411762328 no 176 0.0319934581827061 304 748821 YLR208W SEC13
SGTC_1160 4092-0570 10.5 µM 1.84607534494565 0.0306824128506989 no 177 0.0324406330869719 301 4994975
SGTC_1341 1486-1360 280 µM 1.84593472257412 0.0306922119254679 no 178 0.0324508421132469 286 3976547
SGTC_383 2324-0395 7.37 µM 1.8415990354416 0.0309956122408285 no 179 0.0327669111242108 294 3146421
SGTC_372 0155-0182 15.9 µM 1.83433748714922 0.0315093138684245 no 180 0.0333019564024055 281 771486
SGTC_2572 astragaloside iv 100 µM 1.83101310525298 0.0317468272999914 no 181 0.0335492935119831 285 45006101 An anti-inflammatory agent.
SGTC_672 1441-0018 53.7 µM 1.83018663386655 0.0318061043168924 no 182 0.0336110178857096 258 251141
SGTC_2489 cantharidin 73.42 µM 1.82976341424434 0.0318364942841193 no 183 0.0336426618818675 330 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1193 1488-0126 41.5 µM 1.82607743059087 0.032102187738056 no 184 0.0339192996517108 298 1384710
SGTC_176 1486-1328 72.834 µM 1.82318494844561 0.032311963558034 no 185 0.0341376919712233 337 22310231
SGTC_2389 9091542 195.52 µM 1.82206046334949 0.0323938210706096 no 186 0.0342229059373972 304 3626624 YOL127W RPL25
SGTC_2157 5649910 96.377 µM 1.817788410968 0.0327063687584149 no 187 0.0345482393003144 294 2858091
SGTC_3038 9091290 49.47 µM 1.81702726992456 0.0327623147480649 no 188 0.0346064689443886 271 25236843
SGTC_2189 6047310 154.431 µM 1.81563272813749 0.0328650221636921 no 189 0.0347133648474837 261 711535
SGTC_142 0335-0849 62.6745 µM 1.81476921672152 0.0329287523645779 no 190 0.0347796914705422 426 3889043 YPR107C YTH1
SGTC_2028 5153890 36.43 µM 1.81443910051146 0.0329531430071813 no 191 0.0348050752938924 278 2830968 YPR165W RHO1
SGTC_782 0083-0095 30.5 µM 1.81399819165184 0.0329857427886104 no 192 0.0348390020858 331 3591729 An indicator and reagent.
SGTC_2268 7933382 153.85 µM 1.81301348928052 0.0330586453701087 no 193 0.0349148704111884 343 935025 YOR257W CDC31
SGTC_958 1222-0007 33 µM 1.81300702375386 0.0330591244846617 no 194 0.0349153690081724 302 7312461
SGTC_865 0488-0499 301 µM 1.80967180711048 0.033307037656389 no 195 0.0351733485281419 281 9634651
SGTC_2341 7987486 176.74 µM 1.80890169120404 0.0333644989315188 no 196 0.0352331388187886 303 1258686
SGTC_574 1315-0397 40 µM 1.80649552494448 0.0335445583175591 no 197 0.0354204862626048 358 6794277
SGTC_3093 9117344 49.47 µM 1.80384266069388 0.033744005041044 no 198 0.0356279879739002 257 24824913
SGTC_3168 9103419 49.47 µM 1.79948410674547 0.0340738061266662 no 199 0.0359710678821153 159 16649256
SGTC_88 0180-0332 8.668 µM 1.79886065390647 0.0341211972285524 no 200 0.0360203629483222 283 3101745
SGTC_118 0083-0097 135.343 µM 1.79468941982009 0.0344396651119339 no 201 0.0363515985900871 545 5207356
SGTC_2175 5807670 165.306 µM 1.79082096686273 0.0347371949588736 no 202 0.0366610147631595 265 241186
SGTC_1264 0783-0040 158 µM 1.7897846064255 0.0348172608402212 no 203 0.0367442723956515 273 2855798
SGTC_1614 st002383 48.6 µM 1.78618653898269 0.03509641293767 no 204 0.0370345299381939 288 1947235
SGTC_1694 st024011 44.9 µM 1.78379762024979 0.0352827670575629 no 205 0.0372282782110775 313 2787533
SGTC_1020 4335-0961 93.3 µM 1.78285519011784 0.0353565067945202 no 206 0.0373049394943644 272 669075
SGTC_1365 1672-3266 55.4 µM 1.78026438729065 0.0355598737481962 no 207 0.0375163512146104 302 6415873
SGTC_3282 9108498 15.4605 µM 1.77884926318261 0.0356713592696149 no 208 0.0376322390648961 307 16459645
SGTC_2716 st080858 38.6235 µM 1.76957384160891 0.0364092021618603 no 209 0.0383990798426782 256 5296050
SGTC_18 0111-0177 500 nM 1.76808831141211 0.036528525717777 no 210 0.0385230705964308 414 721752
SGTC_1169 aniline yellow 25.8 µM 1.75409683003583 0.0376681462827964 no 211 0.0397069583833818 255 6051 A DNA damaging agent.
SGTC_467 ro 31-8220 72.8 µM 1.74972200465519 0.0380303797840561 no 212 0.0400831473916298 369 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1038 k292-0204 154 µM 1.7407371333707 0.0387832348508608 no 213 0.0408648330571278 301 4454212
SGTC_2311 7694451 200 µM 1.73371112454144 0.0393803749354445 no 214 0.0414846758399533 319 2163142
SGTC_1757 st041620 31.8375 µM 1.72874210081329 0.0398071913505591 no 215 0.0419276313765093 320 5289815
SGTC_1641 st009299 47.1 µM 1.72783022267921 0.0398859244142175 no 216 0.0420093336119801 224 4046054
SGTC_952 1185-0122 232 µM 1.72522077560612 0.0401119279417013 no 217 0.0422438464910288 326 678600
SGTC_1881 5652484 16 µM 1.71977267383337 0.0405871405532148 no 218 0.0427368858194475 338 2255129
SGTC_3133 9127736 49.47 µM 1.71810197377216 0.0407337801281604 no 219 0.0428890084458816 308 27243420
SGTC_367 0335-0881 7.1 µM 1.71761115066514 0.0407769419389462 no 220 0.0429337825390322 359 23828853
SGTC_565 1418-0001 44.5 µM 1.70222805221113 0.0421486081557476 no 221 0.0443563130240445 374 2862145
SGTC_3076 9116187 49.47 µM 1.70105396669095 0.0422548135917801 no 222 0.0444664269319054 291 27241210
SGTC_396 dithiazanine 1.25 µM 1.68954644780691 0.0433072621849663 no 223 0.0455573793014993 273 10578 An antihelmenthic.
SGTC_1062 mesoridazine 14.2 µM 1.68809559424574 0.0434414433129175 no 224 0.0456964400300552 345 4078 A neuroleptic.
SGTC_293 4049-0273 38.5 µM 1.68393179278208 0.0438283939405794 no 225 0.0460974256073827 286 1380311
SGTC_767 0929-0023 86 µM 1.6823467929668 0.0439764199077067 no 226 0.0462508061881543 456 1204563
SGTC_19 0279-0214 38.434 µM 1.67795598785195 0.0443885913634551 no 227 0.046677845669235 418 3566274 YBR002C RER2
SGTC_1027 k015-0025 8.67 µM 1.675577936261 0.0446131188446063 no 228 0.0469104467631928 350 3598955
SGTC_1039 k821-0043 94 µM 1.67282129938093 0.0448745349214091 no 229 0.0471812402669021 336 15992768
SGTC_1068 loratadine 26.9 µM 1.66495846901593 0.0456269595810327 no 230 0.0479605209247068 331 3957 A H1 histamine antagonist.
SGTC_344 k064-0035 6.43 µM 1.6639107493668 0.0457279813042851 no 231 0.0480651332714495 334 5088750
SGTC_2069 5228469 200 µM 1.66335677341117 0.0457814685963611 no 232 0.0481205202281713 310 2835210
SGTC_2148 5546263 113.568 µM 1.66245402558193 0.0458687381099087 no 233 0.0482108870873738 339 792097
SGTC_623 k072-0108 16.9 µM 1.6620219070563 0.0459105587120804 no 234 0.0482541910379284 352 5382803
SGTC_2730 imipramine 71.33 µM 1.66136869074296 0.0459738354022388 no 235 0.048319710956726 421 3696 A tricyclic antidepressant.
SGTC_2625 euphol 100 µM 1.65888515373126 0.0462150540852056 no 236 0.0485694684091451 391 6708538 A triterpene alcohol.
SGTC_2192 5915882 198.485 µM 1.65601568816067 0.0464950213099752 no 237 0.0488593209159349 278 2876149
SGTC_2837 9008476 45.46 µM 1.65389545206764 0.0467027611659995 no 238 0.049074378440634 387 2992805
SGTC_2950 9072895 21.46 µM 1.65275715717371 0.0468145976752951 no 239 0.0491901483105097 398 17332245
SGTC_2463 5473429 200 µM 1.64759480868066 0.0473244930222163 no 240 0.0497179232184277 307 5399405
SGTC_791 1348-1292 225 µM 1.64714856115133 0.0473687779585825 no 241 0.0497637568687003 436 5437054
SGTC_561 1550-0330 72.9 µM 1.64683224748463 0.0474001885598473 no 242 0.0497962655482054 320 6812934
SGTC_1954 st077032 68.9 µM 1.64490202318023 0.0475922256444102 no 243 0.0499950088226204 319 698907
SGTC_2543 pimpinellin 60.67 µM 1.64406917177228 0.0476752778541936 no 244 0.0500809574980135 333 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.63565704662198 0.0485206599130295 no 245 0.0509556919466899 362 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1149 3909-7961 23.3 µM 1.62913603003849 0.0491842064649511 no 246 0.0516421126759372 346 735261
SGTC_2638 epoxomicin 18 µM 1.62828597602965 0.0492712351715313 no 247 0.0517321308548743 372 9915668 A protesome inhibitor.
SGTC_1846 st056244 14.8 µM 1.62823728720318 0.0492762236645382 no 248 0.0517372906303408 394 5393182
SGTC_1935 st074532 41.6 µM 1.62781041924653 0.0493199763853152 no 249 0.0517825452780367 435 2829742
SGTC_2089 5281248 129.67 µM 1.62523852425568 0.0495842449220357 no 250 0.0520558723785791 360 2737878
SGTC_2026 5148700 152 µM 1.62176680883182 0.0499427630777943 no 251 0.0524266438687494 349 79838
SGTC_1128 3448-9350 235 µM 1.62032913312278 0.0500918334124631 no 252 0.0525807969807805 350 619386
SGTC_2540 epiandrosterone 100 µM 1.61830534718691 0.0503022775238481 no 253 0.0527984044507724 497 441302 A steroid.
SGTC_2508 celastrol 40.54 µM 1.61778729519984 0.0503562604614689 no 254 0.0528542226593356 315 122724 Celastrol is a natural product and antioxidant.
SGTC_1493 4348-0038 111 µM 1.61333172026516 0.0508224560938624 no 255 0.0533362293150218 396 800424
SGTC_577 r071-0003 38.6 µM 1.60939178212448 0.0512375566813299 no 256 0.0537653505399595 506 4568517 YMR134W ERG29
SGTC_2709 st078560 56 µM 1.60849670260044 0.0513322346894844 no 257 0.0538632188989749 342 17250903
SGTC_3041 9091929 49.47 µM 1.60825187335156 0.0513581559934925 no 258 0.0538900131826721 381 25236887
SGTC_1916 st067606 49.2 µM 1.60536487367751 0.051664603061373 no 259 0.0542067649846993 420 19590279
SGTC_1050 3232-1156 69.3 µM 1.60415883296706 0.0517930506649214 no 260 0.0543395231799427 369 700529
SGTC_1072 oxiconazole 14.9 nM 1.59991913822161 0.052246608645099 no 261 0.0548082615357424 408 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_765 1319-0117 244 µM 1.59198605700266 0.0531037491915177 no 262 0.0556939187354878 340 3487746 YGL099W LSG1
SGTC_3251 9135047 49.47 µM 1.59014860206835 0.0533038612337087 no 263 0.0559006564197616 285 17682963
SGTC_1335 1486-0900 202 µM 1.5881512592442 0.0535220636977374 no 264 0.0561260697989913 417 X1335
SGTC_1291 0993-0025 5.79 µM 1.58601404711496 0.0537563295200962 no 265 0.0563680615399275 358 4353356
SGTC_1870 st057514 26.5 µM 1.58316845526633 0.0540695023851897 no 266 0.0566915371172562 374 5393161
SGTC_2939 9044578 71.43 µM 1.58214930359989 0.0541820161540689 no 267 0.0568077452496625 383 2653634
SGTC_1011 4112-3381 17.4 µM 1.57873651518118 0.0545601355789797 no 268 0.0571982527800181 382 2877139
SGTC_558 k064-0027 21.3 µM 1.56481981033142 0.0561236822468505 no 269 0.0588125826719548 389 5088526
SGTC_1602 st001878 87.6 µM 1.55721539717416 0.0569928495283083 no 270 0.0597096769725105 359 595405 YLR310C CDC25
SGTC_939 1165-0479 45.3 µM 1.55551930489857 0.0571881471103041 no 271 0.0599112202619491 421 1377347
SGTC_2676 harmalol 100 µM 1.55105739696973 0.0577044320380976 no 272 0.0604439648052274 398 5459187 A monoamine oxidase inhibitor
SGTC_98 0074-0023 107.663 µM 1.55050104470563 0.0577690634324298 no 273 0.060510651473113 421 3563821
SGTC_2819 7996655 46.38 µM 1.55029101565136 0.0577934772832136 no 274 0.0605358413806314 348 6456960
SGTC_2517 totarol 10 µM 1.53821512975844 0.059210873238055 no 275 0.0619980114292051 372 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2267 7931562 200 µM 1.52748629789392 0.0604928994569509 no 276 0.0633200659328506 374 934880
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.52593012897758 0.060680641732422 no 277 0.0635136331588846 437 16486 A toxic proline analog.
SGTC_2327 6189656 200 µM 1.52350748905188 0.0609738250824469 no 278 0.0638158942459061 370 5349088
SGTC_44 0929-0055 61.211 µM 1.52115494668816 0.0612595840021379 no 279 0.0641104792150275 375 1379590
SGTC_2675 theaflavin digallate 100 µM 1.52042960443851 0.0613479007037757 no 280 0.0642015193574538 411 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_73 0327-0325 16.231 µM 1.51113662905467 0.0624882216220788 no 281 0.0653768220053344 473 53298
SGTC_1945 st075991 56.6 µM 1.5009627194695 0.0637555173912635 no 282 0.0666826021642619 388 1084980
SGTC_2761 levamisole 97.89 µM 1.49870769552365 0.0640390991400778 no 283 0.0669747397214501 394 26879 An alkaline phosphatase inhibitor.
SGTC_3045 9092950 49.47 µM 1.49774293008983 0.06416072287348 no 284 0.0671000267043622 449 44120432
SGTC_1421 4029-0249 71.4 µM 1.49614988393215 0.0643619441310873 no 285 0.0673073005013571 449 2894095
SGTC_2687 chenodiol 100 µM 1.49593464246982 0.064389169329935 no 286 0.0673353438287509 408 5702181 A cholesterol synthesis inhibitor.
SGTC_116 0155-0182 31.788 µM 1.49507698407484 0.0644977406516134 no 287 0.0674471759204446 579 771486
SGTC_2662 daunorubicin 22.37 µM 1.49507624180058 0.064497834677971 no 288 0.0674472727694603 368 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1820 st053765 18.6 µM 1.48459416031005 0.0658362857128146 no 289 0.0688256816677715 406 3690829
SGTC_1250 0485-0349 40.2 µM 1.48448487775875 0.0658503524706013 no 290 0.0688401660273509 444 6842794 YDL195W SEC31
SGTC_1661 st013063 9.66 µM 1.48443676521331 0.0658565462153173 no 291 0.0688465436312653 471 721395
SGTC_2447 5741742 33.78 µM 1.48426056932708 0.0658792325599441 no 292 0.0688699033321051 445 1776504
SGTC_122 0236-0016 402.397 µM 1.48243096873518 0.0661151634206771 no 293 0.0691128294280536 507 6808838
SGTC_268 camptothecin 39.6153 µM 1.47946499686531 0.0664990216777086 no 294 0.0695080399060729 553 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_729 4092-0585 94.1 µM 1.47786297281798 0.0667070732100887 no 295 0.0697222294070943 404 2169061
SGTC_3277 9138724 49.47 µM 1.47635644461739 0.0669031821331828 no 296 0.0699241143832879 320 15943418
SGTC_1158 4092-0494 91.8 µM 1.4762424237019 0.0669180426855644 no 297 0.0699394122495481 448 1148199
SGTC_2667 digitoxin 100 µM 1.45645605201893 0.0695357135798016 no 298 0.0726332950866263 337 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1861 st057647 17.4 µM 1.45520033801501 0.0697044643444359 no 299 0.0728069036780648 444 688668
SGTC_431 k089-0097 107 µM 1.45316381524834 0.0699788151159935 no 300 0.0730891381001932 529 5499420
SGTC_1973 st070275 50.2 µM 1.44366810126343 0.0712690135260773 no 301 0.0744161792106796 413 17118334
SGTC_1049 3226-0134 66 µM 1.44239863499505 0.0714428729952145 no 302 0.0745949743573921 493 5702385
SGTC_354 2783-3500 4.88 µM 1.43790611056684 0.0720607606060897 no 303 0.0752303478464858 462 6740761
SGTC_589 1227-0070 34.1 µM 1.43606045966418 0.0723157896574576 no 304 0.075492569046945 450 2841384
SGTC_1510 1123-0200 71.5 µM 1.43207299491917 0.0728691316686747 no 305 0.0760614660383302 537 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.43142696743448 0.072959085455802 no 306 0.0761539420733044 466 115019
SGTC_2083 5306046 65.942 µM 1.43068863455197 0.0730619960303316 no 307 0.0762597359941575 484 539837
SGTC_3083 9117465 49.47 µM 1.42821425233133 0.0734076913103058 no 308 0.0766150997944885 470 16420915
SGTC_730 1436-0052 41.2 µM 1.42803857229178 0.0734322830044346 no 309 0.0766403782716055 407 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3205 9113483 49.47 µM 1.42725315129648 0.0735423033016209 no 310 0.076753469521485 503 17018033
SGTC_3118 9124250 49.47 µM 1.42398179790521 0.0740019045064638 no 311 0.077225870612855 412 1504786
SGTC_3217 9129673 49.47 µM 1.42101545607289 0.0744205480137614 no 312 0.0776561330908854 464 17248312
SGTC_2021 4019055 173 µM 1.41973236400785 0.0746021916236587 no 313 0.0778428061302813 652 44827708 YER133W GLC7
SGTC_1801 st050089 28.441 µM 1.41899433203986 0.074706825846929 no 314 0.0779503342587686 591 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2029 5175081 200 µM 1.41547924572099 0.0752067134031804 no 315 0.0784640146624672 507 1380876
SGTC_16 erodoxin 22.806 µM 1.41418171590892 0.0753918808098029 no 316 0.0786542775022893 544 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1219 1469-0211 33.1 µM 1.41055403376941 0.0759114225537016 no 317 0.0791880766816322 442 6822282
SGTC_2894 9048625 32.47 µM 1.40768785638895 0.0763238291580732 no 318 0.0796117596176164 450 4092861
SGTC_1670 st016595 4.04 µM 1.40627047545222 0.0765284012921676 no 319 0.079821911895128 489 597879
SGTC_1633 st005664 67.9 µM 1.40148643945436 0.0772219667119389 no 320 0.0805343299189459 499 2063822
SGTC_778 3456-2434 196 µM 1.39621640957526 0.0779915056583271 no 321 0.0813246683371804 574 5539063
SGTC_1235 benzylparaben 21.5 µM 1.39573897657264 0.0780615076791858 no 322 0.0813965562728489 480 7180
SGTC_217 ketoconazole 989 nM 1.3942324165985 0.0782827145430114 no 323 0.0816237159462922 484 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3065 9113888 49.47 µM 1.39000693994281 0.0789056738188999 no 324 0.0822633849856795 442 16648368
SGTC_664 1222-0054 14.9 µM 1.38787580208519 0.0792212873061915 no 325 0.0825874337132095 491 6813991
SGTC_3284 9108171 64.8615 µM 1.3870618873129 0.0793420769184627 no 326 0.0827114461990748 448 8687505
SGTC_1776 st049249 45.9 µM 1.3841330150581 0.0797778919220571 no 327 0.0831588646905487 513 1822314
SGTC_3011 9081274 71.4286 µM 1.38024509099744 0.0803592074576922 no 328 0.0837555974563676 532 6625322
SGTC_1159 4092-0538 61.2 µM 1.37965884531833 0.0804471388690657 no 329 0.0838458549577782 535 717301
SGTC_1736 st036774 51 µM 1.37950872799059 0.080469666761069 no 330 0.0838689785389946 510 1272247
SGTC_355 1311-2252 105 µM 1.37849259517457 0.080622281686254 no 331 0.0840256262550362 504 5338538
SGTC_2412 st077135 33.4 µM 1.37720671024965 0.0808157244323138 no 332 0.0842241739034681 501 13258915
SGTC_1902 st060212 70.5 µM 1.37211673911575 0.0815848767586653 no 333 0.0850135496485139 503 688944
SGTC_2778 tioconazole 65.09 nM 1.36993208264087 0.0819166909906678 no 334 0.0853540518358822 529 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3347 9188721 44.724 µM 1.36576873726229 0.0825518504681744 no 335 0.086005780901142 454 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1315 1237-0019 3.69 µM 1.36385054745411 0.0828457337471113 no 336 0.0863073038506917 513 825140
SGTC_1715 st032160 10.2275 µM 1.36307886373671 0.0829641841476516 no 337 0.086428828638882 494 5289825
SGTC_198 3454-2873 16.191 µM 1.36301426219199 0.0829741060051805 no 338 0.0864390078938542 494 710957
SGTC_903 1134-0042 114 µM 1.36113711923139 0.0832627977660564 no 339 0.0867351805839963 495 701009
SGTC_2238 6671620 73.2395 µM 1.35957130848225 0.083504185900137 no 340 0.0869828113474092 483 729941
SGTC_1684 st024538 14.6195 µM 1.35932871859206 0.0835416309872027 no 341 0.0870212237972679 511 6732859
SGTC_412 gemfibrozil 100 µM 1.35924284806022 0.0835548886004824 no 342 0.0870348238444888 430 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2488 5268135 45.7 µM 1.35398191974784 0.0843701459240919 no 343 0.0878710730248294 615 1270356 YLR208W SEC13
SGTC_1186 1319-0216 26 µM 1.35169445661306 0.084726477742925 no 344 0.0882365395714063 553 4565136
SGTC_2186 6124449 200 µM 1.35048453213399 0.0849154106763746 no 345 0.0884303059751025 484 3834182 YLR033W RSC58
SGTC_286 k060-0067 22.9 µM 1.34946908331724 0.0850742193390445 no 346 0.088593172139979 481 5985051
SGTC_2812 7970281 58.44 µM 1.34736764855677 0.0854035749498128 no 347 0.0889309272756444 515 2233435
SGTC_847 0342-0274 5.54 µM 1.34609073625455 0.0856041699890158 no 348 0.0891366279226564 513 18097
SGTC_316 k060-0003 58.6 µM 1.34581126214456 0.0856481206649207 no 349 0.089181696221079 494 6152314
SGTC_2552 juarezic acid 87.02 µM 1.34284370301711 0.0861158477409469 no 350 0.0896612943990408 601 1549512
SGTC_711 k292-0785 179 µM 1.3420516653962 0.0862410059520118 no 351 0.089789622142496 516 4146315
SGTC_797 k781-0471 270 µM 1.34023404511577 0.0865287415709526 no 352 0.0900846332133358 518 23738129
SGTC_90 0870-0863 4.608 µM 1.33893338959505 0.086735079968576 no 353 0.0902961793083281 566 1738164
SGTC_1400 3771-8998 51.5 µM 1.33817447508431 0.0868556453158157 no 354 0.090419783852301 481 670767
SGTC_1078 idebenone 36.1 µM 1.33558133765397 0.0872685503439753 no 355 0.0908430766800602 586 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2581 avocatin a 64 µM 1.33533609550983 0.0873076759532724 no 356 0.0908831849498725 566 6710728 A skin care supplement.
SGTC_2561 acetosyringone 100 µM 1.33389003407294 0.0875386449959338 no 357 0.0911199490785225 591 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1474 0330-0125 5.35 µM 1.33370443242543 0.0875683228059467 no 358 0.0911503707926887 507 X1474
SGTC_20 0481-0013 4.944 µM 1.3235696203324 0.0892003060131471 no 359 0.0928230101082871 530 182045
SGTC_1931 st074438 57.1 µM 1.3226088453994 0.0893561838837119 no 360 0.0929827455755399 495 2787313
SGTC_2859 9028643 45.46 µM 1.31926367981721 0.0899004906752757 no 361 0.0935404878499684 483 17151580
SGTC_2431 5490079 200 µM 1.31110556057299 0.091238261081716 no 362 0.0949110511940681 551 5722345
SGTC_3326 9140064 16.379 µM 1.31070879121052 0.0913036978022791 no 363 0.0949780837104307 512 1868434
SGTC_2735 sertaconazole 140 nM 1.30735876716036 0.0918575842404571 no 364 0.0955454470374416 456 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2641 levomentholum 100 µM 1.30636084097373 0.0920230595384158 no 365 0.0957149379877207 469 16666
SGTC_179 1273-0063 6.77 µM 1.30574092560052 0.0921259644813466 no 366 0.0958203377095728 485 3108139
SGTC_1653 st012112 65 µM 1.30066832127918 0.0929712110270064 no 367 0.0966860050556065 508 720429
SGTC_465 cgp-37157 41 µM 1.29444689055696 0.0940156966327411 no 368 0.0977555514188311 407 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1360 1598-0022 39.8 µM 1.29271050645068 0.0943087494046704 no 369 0.0980556013076513 645 761525
SGTC_2800 7887935 81.82 µM 1.29254234535731 0.0943371660069978 no 370 0.0980846956093811 543 2961002
SGTC_2993 9054257 71.4286 µM 1.2904153807564 0.0946971350542226 no 371 0.098453237335722 575 6470217 YGL055W OLE1
SGTC_1222 0366-0074 1.18 µM 1.29024327644499 0.0947263063249905 no 372 0.098483102338948 576 286520
SGTC_816 0325-0417 81.3 µM 1.28686526115495 0.0953002132296276 no 373 0.0990706276646502 513 68101
SGTC_2736 butenafine 14.65 µM 1.28680644033437 0.0953102292020257 no 374 0.0990808808056465 600 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_885 0865-0106 16.8 µM 1.28404055895576 0.0957820771867747 no 375 0.0995638821870859 552 2793380
SGTC_812 4251-0442 148 µM 1.28275954929233 0.0960011934890652 no 376 0.0997881649313611 539 5723007
SGTC_376 3970-0862 59.1 µM 1.27969527516228 0.0965268316427289 no 377 0.100326163485004 575 3135186
SGTC_2977 9011197 71.43 µM 1.27684083836452 0.0970183741812451 no 378 0.100829222205304 482 2704722
SGTC_79 0052-0007 94.094 µM 1.2766602436645 0.0970495348160695 no 379 0.100861111513576 579 2801472
SGTC_1339 1486-1321 22.7 µM 1.27349409478614 0.0975970305049465 no 380 0.101421383355475 580 3469382
SGTC_2038 4100038 30.985 µM 1.27231567462713 0.0978013821673022 no 381 0.10163049076728 575 3596803
SGTC_1527 coumarin 137 µM 1.27043530646707 0.0981281089854296 no 382 0.101964806751103 511 323 A hepatotoxic, DNA x-linker.
SGTC_3096 9117468 49.47 µM 1.27016997580789 0.0981742763048724 no 383 0.102012044998337 443 41316311
SGTC_2466 5983409 37.09 µM 1.2695965631241 0.0982741039947718 no 384 0.102114187140078 554 2879657
SGTC_2695 st077686 51.995 µM 1.26761858651156 0.0986190283489127 no 385 0.102467095586603 527 2876092
SGTC_269 exalamide 29 µM 1.26293649649769 0.0994390324239058 no 386 0.103306001249788 552 3316 A derivative of salicylamide.
SGTC_2407 paclitaxel 400 µM 1.26192265077289 0.0996172482038224 no 387 0.103488310296423 599 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3261 9137475 49.47 µM 1.26152401835383 0.0996873844757102 no 388 0.103560056025011 355 17027690
SGTC_1439 4092-1168 46 µM 1.26044216381167 0.0998779101729479 no 389 0.103754949735143 574 2886240
SGTC_3139 9095020 49.47 µM 1.2599046713509 0.0999726669496094 no 390 0.103851876693296 434 25236292
SGTC_2364 9055074 200 µM 1.2592512234219 0.100087954398297 no 391 0.103969802541769 530 6470630
SGTC_477 mead ethanolamide 10 µM 1.25595965590021 0.100670159960866 no 392 0.104565298849837 399 16061185
SGTC_1026 k007-1105 30.6 µM 1.25471425836321 0.100891086150537 no 393 0.104791253910031 667 7066794
SGTC_2418 pentamidine 31.67 µM 1.25413651479373 0.100993694403083 no 394 0.104896195096917 547 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2362 9071156 126 µM 1.25395276111827 0.101026345311737 no 395 0.104929588007885 559 653133
SGTC_772 k072-0172 35.3 µM 1.25389506735843 0.101036598414421 no 396 0.104940074079827 529 5861980
SGTC_641 4092-0595 30 µM 1.25293689887726 0.101206991174323 no 397 0.105114335973798 601 786260
SGTC_2754 granisetron 64.02 µM 1.24952035975174 0.101816264626365 no 398 0.105737405783463 595 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_670 4204-0025 119 µM 1.24748631557238 0.102180262513222 no 399 0.106109617405084 611 719039
SGTC_2938 9059746 27.26 µM 1.24370933424695 0.102858673052043 no 400 0.106803279677102 557 6471769
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.24102526227364 0.103342763636527 no 401 0.107298208367042 608 94937 An inhibitor of serotonin biosynthesis.
SGTC_1175 0741-0056 27.6 µM 1.24057319029714 0.103424460365836 no 402 0.107381730488015 656 765927
SGTC_752 1896-0090 130 µM 1.23920044599607 0.103672824788023 no 403 0.107635637727835 589 772567
SGTC_3244 9134489 49.47 µM 1.23714219123601 0.10404602591236 no 404 0.108017149288184 587 16584271
SGTC_2398 5228213 48.84 µM 1.23678706972245 0.104110514673217 no 405 0.108083071849757 683 80771 YMR134W ERG29
SGTC_403 arphamenine a 50 µM 1.23373423776207 0.104666093364329 no 406 0.108650975730333 602 5487158 An arginine aminopeptidase inhibitor.
SGTC_1950 st077106 7.18 µM 1.23224335588946 0.104938195014233 no 407 0.10892909607461 612 13831864
SGTC_2235 salicylic acid 500 µM 1.23191822910087 0.104997602034445 no 408 0.10898981559015 564 338 A COX inhibitor and kinase inhibitor.
SGTC_55 0767-0285 6.563 µM 1.23045316928082 0.105265599117906 no 409 0.109263726731841 633 3116166
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.23025428489935 0.105302018300519 no 410 0.109300948731642 634 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1573 oleylamine 1.06 µM 1.22900568569384 0.105530866762297 no 411 0.10953483714041 593 5356789 An amine of the fatty acid oleic acid.
SGTC_2863 9028737 58.44 µM 1.22807990518961 0.105700779726044 no 412 0.109708486823631 549 6460917
SGTC_1898 st060199 18.6 µM 1.22568763069493 0.106140761094513 no 413 0.110158123360719 575 688866
SGTC_123 0083-0120 66.675 µM 1.22542193678463 0.106189708390224 no 414 0.11020814292114 626 16001701
SGTC_2519 cryptotanshinone 88.04 µM 1.22422212613948 0.106410945826737 no 415 0.110434222265758 582 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_490 phenamil 164 µM 1.22414338834513 0.106425476203037 no 416 0.110449070382355 481 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_522 1273-0010 11.6 µM 1.22231905923966 0.106762541528692 no 417 0.110793497258526 574 5705015
SGTC_2375 9072683 200 µM 1.22190857772522 0.106838488658161 no 418 0.110871100661089 672 16798029
SGTC_2329 6138490 200 µM 1.21900811734748 0.107376241746405 no 419 0.11142055578516 539 720019
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.21844274036108 0.107481290979495 no 420 0.111527885804319 633 442882
SGTC_2125 5246583 200 µM 1.21637585967732 0.107865955719756 no 421 0.111920887797821 705 835267
SGTC_61 0978-8327 98.565 µM 1.21252677744176 0.108584944465506 no 422 0.112655399388508 633 6150059 YHR072W ERG7
SGTC_3010 9080089 71.4286 µM 1.21090618034772 0.108888692669277 no 423 0.112965681848009 616 17027233
SGTC_1358 1509-0022 2.48 µM 1.2103970032217 0.10898425363585 no 424 0.113063295638336 616 3258434
SGTC_1836 st055642 81 µM 1.21039560603178 0.108984515939529 no 425 0.113063563574873 613 8571
SGTC_69 0096-0274 206.684 µM 1.20917691849448 0.109213481040226 no 426 0.113297441634039 683 6741392
SGTC_3260 9137109 49.47 µM 1.20493031788401 0.110014025758257 no 427 0.114115101695204 497 17478346
SGTC_3310 9130229 44.1445 µM 1.2039383127023 0.110201637984884 no 428 0.114306711072449 610 7761258
SGTC_2747 doxorubicin 7.63 µM 1.203638371148 0.110258409360276 no 429 0.114364690944637 419 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_262 fenpropimorph 62.5 µM 1.20157658167388 0.110649221830152 no 430 0.114763809592654 563 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.20129355878418 0.110702946254161 no 431 0.114818674071909 599 756377
SGTC_2608 thymoquinone 42.66 µM 1.19405197065863 0.112083933815208 no 432 0.116228819623344 568 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2630 antimycin a 100 µM 1.19397298757021 0.112099063662015 no 433 0.116244267357341 650 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1177 0983-0204 23.6 µM 1.19134246644038 0.112603795438717 no 434 0.116759584548104 683 766818
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.19029549651744 0.112805133896492 no 435 0.116965135109828 549 77254
SGTC_3236 9132701 49.47 µM 1.18524122852571 0.113780714650026 no 436 0.117961041606915 626 24282524
SGTC_2650 prasterone 100 µM 1.18074402317691 0.114653813375958 no 437 0.118852213629986 534 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2142 5622915 118.518 µM 1.18015311382249 0.114768887424318 no 438 0.118969661513441 591 5322196
SGTC_1567 st069303 68.4 µM 1.17877924520844 0.115036752997047 no 439 0.119243045433675 654 5581319
SGTC_2428 5615643 7.78 µM 1.176045496007 0.115571078676869 no 440 0.11978834806192 608 2253075
SGTC_1292 0kpi-0043 232 µM 1.17599724774852 0.115580524861137 no 441 0.119797987936198 614 3333905
SGTC_1055 3448-0672 86 µM 1.17482506161752 0.115810187430324 no 442 0.120032355711234 630 748378
SGTC_2022 5136654 200 µM 1.17204725088188 0.116355728213608 no 443 0.120589043061861 632 1713771
SGTC_1812 st052057 4.327 µM 1.17141498741731 0.116480154229335 no 444 0.1207160054323 665 3645418
SGTC_692 k241-0027 77.8 µM 1.17120819898768 0.116520869542942 no 445 0.120757550226973 628 3600480
SGTC_2034 5197015 53.07 µM 1.17109576732367 0.11654301085101 no 446 0.120780142514522 647 780676
SGTC_492 tmb-8 126 µM 1.16803777766585 0.11714636918908 no 447 0.121395763442193 472 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2064 5220758 200 µM 1.16473197775562 0.117801107448 no 448 0.122063750328975 693 788518
SGTC_2744 captopril 92.04 µM 1.1628932591405 0.118166398033183 no 449 0.122436406355945 575 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1284 0929-0043 16 µM 1.16264157741675 0.118216460853773 no 450 0.122487477146557 663 1239883
SGTC_2593 nobiletin 86.24 µM 1.16078800612929 0.118585622659525 no 451 0.122864060860749 593 72344 An anti-infammatory.
SGTC_1019 4262-0212 3.4 µM 1.15695687797876 0.119351219647868 no 452 0.123644989366059 732 4677213
SGTC_2121 5257820 149.641 µM 1.15570614839252 0.119601913908461 no 453 0.123900686208515 711 791256
SGTC_1991 st073000 8.92 µM 1.15075551842747 0.120597854242369 no 454 0.12491641457777 718 4301969 YIL048W NEO1
SGTC_927 2425-1185 123 µM 1.1505419773607 0.120640944231318 no 455 0.124960357622669 651 730375
SGTC_3342 9147791 14.508 µM 1.1486442687621 0.121024354966742 no 456 0.125351347541795 666 1838168
SGTC_803 4488-1585 147 µM 1.14845586911276 0.121062465729979 no 457 0.125390210568863 659 747204
SGTC_401 neomycin 50 µM 1.14674776403109 0.121408378148872 no 458 0.125742941819142 633 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3249 9135183 49.47 µM 1.144682901936 0.121827465284783 no 459 0.126170268350466 693 4902779
SGTC_2815 7968870 71.43 µM 1.13580360366965 0.12364119741292 no 460 0.128019384272444 704 2977326 YHR190W ERG9
SGTC_2393 9031399 185.94 µM 1.13458772164858 0.123891024101646 no 461 0.128274050028295 669 1526623 YDL150W RPC53
SGTC_74 000s-0487 160.283 µM 1.13003939272961 0.12482869904511 no 462 0.129229812945766 650 677548
SGTC_1029 k015-0030 64.7 µM 1.12101654888068 0.12670348034714 no 463 0.131140409131142 671 2208316
SGTC_1825 st052143 62.6 µM 1.11861201212323 0.127206390932213 no 464 0.131652848328214 651 674173
SGTC_2605 digitonin 300 nM 1.11843523498141 0.127243418724899 no 465 0.131690576375302 793 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_969 1313-0238 134 µM 1.11687257003167 0.127571061102549 no 466 0.132024407187095 726 5212874
SGTC_1458 k015-0034 6.33 µM 1.1151756496932 0.127927516484346 no 467 0.132387579317721 654 3598957
SGTC_177 1327-0068 8.361 µM 1.11456318849992 0.128056339990727 no 468 0.132518826199363 702 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2308 7584454 197.62 µM 1.11285544571908 0.128416018043522 no 469 0.132885258959921 738 893577
SGTC_2910 7948405 25.97 µM 1.11279782125288 0.128428166900744 no 470 0.132897635678162 637 2971328
SGTC_2725 haloperidol 53.21 µM 1.11205200092337 0.128585478782671 no 471 0.133057896336925 693 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2533 agelasine 13.65 µM 1.11126547545119 0.128751521200576 no 472 0.133227047708953 729 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_802 4112-3352 742 µM 1.10922870956873 0.129182191486087 no 473 0.133665765201466 748 704594
SGTC_2336 9001819 198.65 µM 1.10685374852361 0.129685632396819 no 474 0.134178582763302 717 2989602
SGTC_2215 7188065 200 µM 1.10668544190971 0.129721361287175 no 475 0.134214975870619 661 940217
SGTC_1655 st012546 55.1 µM 1.10399201669968 0.130294061369699 no 476 0.134798300382406 664 720985 YLR208W SEC13
SGTC_2645 abamectin 100 µM 1.10358183219997 0.130381431696856 no 477 0.134887287867132 680 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2255 7941087 197.44 µM 1.10112010977143 0.130906636142654 no 478 0.135422192913455 792 935561
SGTC_2441 5730946 39.09 µM 1.10095349742078 0.130942235363405 no 479 0.135458448384894 714 1774275
SGTC_1162 k048-0130 20.1 µM 1.10060656934325 0.131016383201599 no 480 0.135533962577188 704 6797406
SGTC_3071 9117417 49.47 µM 1.09773494591797 0.131631240020271 no 481 0.136160122723616 606 45595590 YGL055W OLE1
SGTC_1615 st002656 86.5 µM 1.09254922296282 0.132746618244479 no 482 0.13729588366769 715 1584458
SGTC_2397 5161689 200 µM 1.09040883092514 0.133208879731974 no 483 0.137766546770113 732 2259942
SGTC_2487 5918373 44.05 µM 1.08973904913109 0.133353760103048 no 484 0.137914054835041 752 2876279
SGTC_649 1123-0311 367 µM 1.08786443608325 0.133759833434997 no 485 0.138327479132092 761 693629 YIL048W NEO1
SGTC_1459 k035-0031 35.7 µM 1.08382513520453 0.134637702056658 no 486 0.139221169209431 640 3877128 YMR208W ERG12
SGTC_3140 9094243 49.47 µM 1.08150416770861 0.135143907082098 no 487 0.139736453894005 736 19291112
SGTC_2862 9027634 71.43 µM 1.08054772675042 0.135352886892806 no 488 0.139949172880831 677 5012562
SGTC_3040 9091894 49.47 µM 1.08000245261958 0.13547212692611 no 489 0.140070544005162 648 25236966
SGTC_36 0335-0881 14.2 µM 1.07982108517967 0.135511804135671 no 490 0.140110929948245 769 23828853
SGTC_2496 diffractaic acid 79.83 µM 1.07727873027648 0.136068825648562 no 491 0.140677880798872 765 94870 An apoptosis inducer which activates caspases.
SGTC_385 1494-0393 12.4 µM 1.07531524177728 0.136500090650715 no 492 0.14111680727025 754 3090647
SGTC_2740 felodipine 17.08 µM 1.0746751370394 0.136640886535589 no 493 0.141260099478081 667 3333 L-type calcium channel blocker
SGTC_734 2023-0417 80 µM 1.07228618818331 0.137167230628411 no 494 0.14179575425226 719 3935732
SGTC_165 k038-0023 64.381 µM 1.07144863370622 0.137352091924701 no 495 0.141983877610156 719 46368543
SGTC_2467 5474540 200 µM 1.06959936246854 0.137760857137156 no 496 0.142399841139782 722 5413519
SGTC_2246 7293507 91.5585 µM 1.06893481144806 0.137907952863941 no 497 0.142549522246117 758 887656
SGTC_2151 5563267 85.4165 µM 1.06857401109555 0.13798785944862 no 498 0.142630832183243 763 5310824
SGTC_3193 9111931 49.47 µM 1.0677745044844 0.13816503897129 no 499 0.142811120647871 721 17087244
SGTC_1103 duloxetine 36.1 µM 1.06540955315614 0.138690046169434 no 500 0.143345317785057 821 60835 A selective serotonin reuptake inhibitor.
SGTC_956 1185-0240 191 µM 1.06254652376819 0.139327440382102 no 501 0.143993824558518 711 1416193
SGTC_2123 5259487 200 µM 1.05844488869821 0.140244052543427 no 502 0.144926331833851 781 2173474
SGTC_856 0433-0016 11.3 µM 1.05644677687488 0.140692060569787 no 503 0.145382072333173 759 3911780
SGTC_3018 9082602 49.47 µM 1.05535772053687 0.140936652599468 no 504 0.145630875863048 770 17332089
SGTC_590 k048-0076 22.4 µM 1.05446629709796 0.141137072650234 no 505 0.145834741544354 735 6832814
SGTC_2349 9023730 187.07 µM 1.05391819875671 0.141260398308726 no 506 0.145960185055404 730 4126287
SGTC_1402 3909-7673 35.9 µM 1.05244154145104 0.141593019166772 no 507 0.146298508979677 730 5328014
SGTC_2522 biochanin a 4.94 µM 1.05211616504259 0.141666382323638 no 508 0.14637312824833 715 5280373 A possible chelator.
SGTC_1153 4055-0057 267 µM 1.05044165452378 0.14204434417676 no 509 0.146757551429458 764 882706
SGTC_1314 1222-0010 41.1 µM 1.04551324682061 0.14316071702339 no 510 0.147892910715546 756 3526027
SGTC_2626 ethyl orsellinate 100 µM 1.04500029286326 0.143277249911108 no 511 0.148011417083809 713 75653 A natural product.
SGTC_2820 7989630 71.43 µM 1.04399149280396 0.143506615959194 no 512 0.148244662801212 635 2984098
SGTC_323 4013-0906 34.3 µM 1.04372461603073 0.143567335893191 no 513 0.148306408769132 764 2910086
SGTC_1265 0819-1001 68.8 µM 1.04340291181739 0.143640553241274 no 514 0.148380862757871 723 3106768
SGTC_1482 3346-2049 8.48 µM 1.04146481596803 0.144082181775787 no 515 0.148829937146012 728 3826804
SGTC_2430 5571206 200 µM 1.03861603775576 0.144732985399902 no 516 0.149491671987115 854 1731771
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.0359177647444 0.145351229086108 no 517 0.15012025455953 702 2374 Ca(2+)-ATPase inhibitor.
SGTC_2118 5526350 200 µM 1.03377545061428 0.145843351713148 no 518 0.150620575424538 786 743594
SGTC_824 1304-0008 100 µM 1.0329105082573 0.146042359289105 no 519 0.150822890341382 772 768245
SGTC_3160 9100216 49.47 µM 1.03038124448991 0.146625343420166 no 520 0.151415537028258 783 17191039
SGTC_2870 9038528 12.99 µM 1.02555754911439 0.147741508038791 no 521 0.152550092921803 687 6463316
SGTC_475 α-linolenic acid 10 µM 1.0252920949029 0.147803096764788 no 522 0.152612692328384 820 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3004 9076122 71.4286 µM 1.02384011610463 0.148140278315953 no 523 0.152955399450979 791 44782551
SGTC_2692 st077426 47.7 µM 1.0213001901726 0.148731342042684 no 524 0.153556118179375 799 25238571
SGTC_439 amiodarone 34.4 µM 1.02129861050762 0.148731710134796 no 525 0.153556492271953 786 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_900 1112-0045 141 µM 1.01807858608681 0.149483303096097 no 526 0.154320305495771 651 56211 YIL048W NEO1
SGTC_1277 0873-0036 22 µM 1.0171955913432 0.149689846946575 no 527 0.154530196442282 814 5965735
SGTC_2049 5262831 67.185 µM 1.01545849168271 0.150096732434049 no 528 0.154943661614013 775 763417
SGTC_1491 4138-0063 26.5 µM 1.01143158797773 0.151042798167594 no 529 0.155904954475286 762 23883227
SGTC_1899 st063254 59.6 µM 1.01106382102553 0.151129397279177 no 530 0.155992942433135 698 3093813
SGTC_1104 tacrolimus 29.8 µM 1.01091011115943 0.15116560155757 no 531 0.156029727095809 831 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_405 ebelactone b 50 µM 1.00950574107177 0.151496649096584 no 532 0.156366074842966 799 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1977 st070720 65.3 µM 1.00836062089668 0.1517669409998 no 533 0.156640685211917 750 682188
SGTC_1805 st050013 60.3 µM 1.00798125733427 0.151856555848997 no 534 0.156731730054294 766 4037144
SGTC_622 1348-1566 26.3 µM 1.00511903455463 0.152533815198277 no 535 0.157419767780315 845 7340407
SGTC_2914 7968218 45.32 µM 1.00296914302109 0.153043838770031 no 536 0.157937874825878 763 2977111
SGTC_3225 9130819 49.47 µM 1.00236275697836 0.153187897241157 no 537 0.158084211328282 806 4547121
SGTC_186 3455-3465 67.277 µM 1.00119696202756 0.153465106251226 no 538 0.158365797500303 736 755278
SGTC_377 3970-0964 33.1 µM 1.00013574792566 0.153717736170714 no 539 0.158622409136992 889 16481235
SGTC_1247 0448-0043 5.84 µM 0.999249346331411 0.153928961575602 no 540 0.158836958316446 825 3089013 YGL099W LSG1
SGTC_501 nsc-95397 161 µM 0.99847424866226 0.154113821104133 no 541 0.159024722731876 786 262093
SGTC_1274 0865-0114 173 µM 0.997444261495409 0.154359698511607 no 542 0.159274458080339 795 870624
SGTC_1117 retinoic acid 1.10837 µM 0.992265147841283 0.155599980028788 no 543 0.160534099944806 868 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1746 st038117 42 µM 0.990737245807884 0.155967130493491 no 544 0.1609069495022 780 2898218
SGTC_2711 st079103 59.1 µM 0.989077467504845 0.156366617005094 no 545 0.161312620506616 799 54693780
SGTC_2560 caryophyllene 100 µM 0.988408260120793 0.156527876769601 no 546 0.161476371877159 905 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2601 securinine 100 µM 0.987961577353308 0.15663557540573 no 547 0.161585732993469 776 442872 A GABA receptor antagonist.
SGTC_89 0302-0250 142.109 µM 0.987628394521111 0.156715940092961 no 548 0.161667337409987 875 4203518 YLR208W SEC13
SGTC_950 1165-0508 94.1 µM 0.98573961679016 0.157172031779155 no 549 0.162130451757751 745 6148369
SGTC_1190 1486-1332 13 µM 0.985349813056056 0.157266267996282 no 550 0.162226136192662 817 4150046
SGTC_609 0986-0026 86.3 µM 0.984583505367911 0.157451633443401 no 551 0.162414347550832 821 2848610
SGTC_2173 5763948 167 µM 0.98414857457085 0.157556904567822 no 552 0.162521233262402 825 2867177
SGTC_2975 9084847 53.72 µM 0.98385304743879 0.157628460659901 no 553 0.162593886163281 825 27211724
SGTC_1420 4'-methoxyflavone 42 µM 0.983760987846629 0.157650755443272 no 554 0.162616522568283 839 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_202 3594-0513 34.79 µM 0.981678974038368 0.158155526037272 no 555 0.163129013522987 785 708429
SGTC_185 k048-0037 25.491 µM 0.981459847356098 0.158208713491485 no 556 0.163183012885065 850 6827589
SGTC_2621 lithochol-11-enic acid 100 µM 0.980133464049955 0.158530909997074 no 557 0.16351012128772 862 6708711
SGTC_832 4083-0019 164 µM 0.979056931700078 0.158792730471134 no 558 0.163775925091358 993 1990758
SGTC_1654 st012436 41.8 µM 0.977840398913457 0.15908894100567 no 559 0.16407663338848 777 4323132
SGTC_1630 st005209 31.3 µM 0.97665071417953 0.159378964241067 no 560 0.164371051423955 896 3367314
SGTC_2010 4012422 159 µM 0.975537253536132 0.159650718868241 no 561 0.164646915943176 828 952393
SGTC_3355 9151058 44.0485 µM 0.975486825027405 0.159663033778377 no 562 0.164659416913434 806 17015728
SGTC_1338 1486-1223 76 µM 0.974266922217175 0.159961129930779 no 563 0.16496201197317 865 3444526
SGTC_1725 st036284 20.55 µM 0.972887456676797 0.16029865515408 no 564 0.165304619859371 908 707914
SGTC_121 0557-0495 61.343 µM 0.972871670589041 0.160302520358331 no 565 0.165308543198753 1037 3104427
SGTC_3195 9113082 49.47 µM 0.972757467121855 0.16033048475167 no 566 0.165336928147515 800 17018038
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.972504067995631 0.160392544627065 no 567 0.165399921044976 860 688751
SGTC_3235 9132602 49.47 µM 0.971555485335894 0.160625000957956 no 568 0.165635868576155 855 4912240
SGTC_1967 st070177 51.4 µM 0.970942693301287 0.160775286549925 no 569 0.16578840824551 808 5729214
SGTC_547 1120-0019 610 nM 0.970520054914055 0.160878990953599 no 570 0.165893666690096 811 3676939
SGTC_2365 9042475 200 µM 0.967877091819175 0.16152849510449 no 571 0.166552878215914 814 6464479
SGTC_548 1436-0017 110 µM 0.967827676474755 0.16154065510861 no 572 0.16656521954033 917 9677137
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.96749715574928 0.161622004166051 no 573 0.166647781212663 783 6708760
SGTC_1431 4049-0260 9.09 µM 0.966172953040829 0.161948189892489 no 574 0.166978822227192 854 3854841
SGTC_2869 9037858 32.47 µM 0.964764440623094 0.162295613642895 no 575 0.16733140519438 837 27187042
SGTC_1722 st034304 3.6505 µM 0.961606771698232 0.163076246210681 no 576 0.168123584318582 829 4036148 YLR033W RSC58
SGTC_3034 9090421 49.47 µM 0.958753720312741 0.163783667066917 no 577 0.168841414302639 811 17173761
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.958289623541289 0.163898929037271 no 578 0.168958367362665 858 5282309
SGTC_3021 9087658 49.47 µM 0.956223336011662 0.164412746001969 no 579 0.16947970624696 855 25237042
SGTC_605 1315-0399 119 µM 0.95608361051538 0.16444752873662 no 580 0.169514997194644 892 24020461
SGTC_194 1486-1323 56.904 µM 0.953931600071254 0.164983844449542 no 581 0.170059133328292 833 5178754
SGTC_2971 9092186 9.93 µM 0.953431162428466 0.165108723708227 no 582 0.170185829310852 774 25236400
SGTC_1768 st044301 37.178 µM 0.952750120010662 0.165278769372821 no 583 0.170358346205483 869 3931349
SGTC_493 zm226600 134 µM 0.952298699622771 0.165391544434024 no 584 0.170472758566006 854 5240098 A potassium channel opener. YCR052W RSC6
SGTC_452 diindolylmethane 8 µM 0.951944938971303 0.165479956662405 no 585 0.170562453478053 792 3071 Inhibits expression of several cancer promoting factors.
SGTC_2925 9010536 32.5 µM 0.950827989662614 0.165759306399966 no 586 0.170845850771241 910 2994177
SGTC_2585 alliin 100 µM 0.950629702545694 0.165808929982435 no 587 0.170896192526794 852 87310 A garlic compound which reacts with lipids.
SGTC_1280 0880-0253 10.1 µM 0.949522615807037 0.166086167368441 no 588 0.171177437587674 850 6836607
SGTC_916 4466-0038 42 nM 0.948342615486678 0.166381993354596 no 589 0.171477531328555 962 5722064 YGL116W CDC20
SGTC_2143 5623677 140.463 µM 0.947118816296967 0.166689158892699 no 590 0.171789118796393 838 5375313
SGTC_1201 1889-3372 45.9 µM 0.94476686849942 0.167280509021111 no 591 0.172388955001141 837 5392199
SGTC_1340 1486-1359 257 µM 0.943657177370905 0.167559987526089 no 592 0.172672431800144 863 4309068
SGTC_557 1315-0110 16.2 µM 0.939633101776566 0.168575982442628 no 593 0.173702895427277 881 6833801
SGTC_2524 avocatin b 10.57 µM 0.93836774131403 0.168896276226973 no 594 0.174027728969798 830 6710748
SGTC_2712 st079126 47.7 µM 0.938033640147537 0.168980910630137 no 595 0.174113561239454 825 3152970
SGTC_3114 9122766 49.47 µM 0.937562660658562 0.169100265267324 no 596 0.17423460393335 786 17176985
SGTC_556 4058-0063 51.5 µM 0.935390111965559 0.169651528631675 no 597 0.174793645428692 903 6615692
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.934515890143622 0.169873678917835 no 598 0.175018921593788 851 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1231 0242-0792 125 µM 0.934206547312875 0.169952331309023 no 599 0.175098679523533 869 3707635
SGTC_1225 1216-0074 20.6 µM 0.931289250681099 0.170695220539585 no 600 0.175851980427288 882 4241466
SGTC_1951 sophoraflavanone G 9.2 µM 0.927386448204127 0.171692313952201 no 601 0.1768629621283 876 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.926700138003478 0.171868037336784 no 602 0.177041122933673 867 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1891 st059073 26.2 µM 0.925666417348988 0.17213292863778 no 603 0.177309682728056 977 688754
SGTC_3001 9076041 71.4286 µM 0.923777026322758 0.17261775874788 no 604 0.177801209378906 867 16004211
SGTC_1141 3253-0389 52.6 µM 0.923322455840801 0.172734534323104 no 605 0.177919594421001 882 5402031
SGTC_697 0508-1955 564 µM 0.923068838374879 0.172799708531959 no 606 0.177985666315325 919 6243113
SGTC_2506 ethyl hematommate 54.16 µM 0.922518321655185 0.172941233360163 no 607 0.17812913901871 793 3940691 An allergen.
SGTC_3234 9132280 49.47 µM 0.920840460715959 0.173373027134275 no 608 0.17856686364683 869 17612295
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.919708655542192 0.173664681954278 no 609 0.178862514132039 911 23665772 A membrane-active detergent.
SGTC_2499 avocadenofuran 51.48 µM 0.91951215883345 0.173715348964773 no 610 0.178913874431902 875 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1617 st002906 78 µM 0.919235483364498 0.173786706145604 no 611 0.178986207585637 903 5150859
SGTC_1789 tunicamycin 25 nM 0.918155102002942 0.174065525073474 no 612 0.179268835236262 890 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_124 0136-0217 7.121 µM 0.917027259622354 0.174356895685514 no 613 0.179564177931132 1001 3976905
SGTC_3081 9117243 49.47 µM 0.9164195693238 0.174514016833085 no 614 0.179723437587609 896 45595589
SGTC_913 3487-1245 167 µM 0.915935157239704 0.174639328217173 no 615 0.179850452810254 844 4016153
SGTC_2874 9043904 71.43 µM 0.912401908618204 0.175555063160471 no 616 0.18077859258811 809 4463428
SGTC_3 0833-0587 95.581 µM 0.912158338092973 0.175618302836312 no 617 0.180842685929918 887 5382644
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.909772598869889 0.176238489594625 no 618 0.1814712240547 977 368090
SGTC_2130 NSC 7 2.4545 µM 0.909197854065401 0.17638810477045 no 619 0.181622848377328 936 21448
SGTC_893 0958-0369 48.9 µM 0.907401221998911 0.176856314566007 no 620 0.18209733173068 923 6819948
SGTC_2401 5128683 200 µM 0.907104801388706 0.176933638435248 no 621 0.182175689637365 839 708373
SGTC_3181 9108277 49.47 µM 0.905975635717464 0.177228386686553 no 622 0.182474374237728 887 17097298
SGTC_425 3825-7017 13.1 µM 0.903539702784143 0.177865298232506 no 623 0.183119763278454 927 3397440
SGTC_3214 9129694 49.47 µM 0.902124842441694 0.178235896825759 no 624 0.183495276808423 862 17158655
SGTC_2831 7999036 19.48 µM 0.902119260537281 0.178237359873738 no 625 0.183496759233599 947 2988270
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.897171328182275 0.179537216373585 no 626 0.1848137510748 897 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_822 1487-0950 154 µM 0.897145944545212 0.17954390015748 no 627 0.184820522553033 921 1958375
SGTC_642 0335-0876 158 µM 0.896124767145433 0.179812916809249 no 628 0.185093065316428 923 6812350
SGTC_381 3461-2219 42.7 µM 0.894916630360543 0.180131512406627 no 629 0.185415828022922 939 2883159
SGTC_1921 5740136 50 µM 0.893324247932386 0.180551977702633 no 630 0.185841778173502 953 1774243
SGTC_2671 danthron 100 µM 0.892863688345837 0.18067370218447 no 631 0.185965087406493 904 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_502 l-744,832 89.3 µM 0.891512264427815 0.181031176298244 no 632 0.186327207471574 937 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1082 camptothecin 424.86 nM 0.891491158391906 0.181036762708209 no 633 0.186332866390535 835 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1269 0831-0796 3.05 µM 0.890732556853503 0.181237623381959 no 634 0.186536332193764 929 927758
SGTC_2739 tacrine 100.86 µM 0.89062422403588 0.181266318867172 no 635 0.186565399545252 895 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2437 5741531 144.16 µM 0.890515636227091 0.181295084750297 no 636 0.186594538129344 961 2262990
SGTC_608 k048-0125 159 µM 0.890299325857188 0.181352395823197 no 637 0.186652591513243 952 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1475 4092-1048 11.7 µM 0.88948336990451 0.181568684082341 no 638 0.186871678429606 935 2881759
SGTC_2900 5328528 85.29 µM 0.888023043509006 0.181956180661072 no 639 0.187264178048084 993 795359
SGTC_2825 7998094 58.44 µM 0.887876164154854 0.181995183596528 no 640 0.187303683778961 875 2987815
SGTC_2750 bromebric acid 70.15 µM 0.887634475025166 0.182059374079179 no 641 0.187368701445433 964 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2659 sanguinarine 24.21 µM 0.887202958825227 0.182174016134627 no 642 0.187484819864998 881 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2136 5328288 199.296 µM 0.885915741143016 0.182516262655752 no 643 0.187831466543639 817 262395
SGTC_708 3448-5400 146 µM 0.885721357568684 0.182567980404162 no 644 0.187883848260184 929 3462195
SGTC_3068 9116768 49.47 µM 0.885367414236246 0.18266217416872 no 645 0.187979250671924 877 41904888
SGTC_2241 6772625 37.8075 µM 0.883641695233073 0.183121868580334 no 646 0.18844483179025 919 2285411
SGTC_1119 parthenolide 318.541 nM 0.882203082899622 0.183505635000072 no 647 0.188833497550397 983 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1363 1636-0063 10.4 µM 0.880626432948693 0.183926799829325 no 648 0.189260023431128 966 6072185
SGTC_1398 3558-0053 112 µM 0.879514936999186 0.184224071201631 no 649 0.189561068907955 878 4532369
SGTC_581 0958-0271 211 µM 0.878644607764804 0.184457050760479 no 650 0.18979700061988 1000 4591145
SGTC_2158 5657123 3.6195 µM 0.877522783687281 0.18475762353273 no 651 0.190101374631497 954 2858827
SGTC_3306 9127676 59.7925 µM 0.87684341826305 0.184939795327711 no 652 0.190285846232744 903 41905287
SGTC_1308 1187-1617 41.4 µM 0.876297664786306 0.185086219905568 no 653 0.190434117112988 967 2882570
SGTC_717 1532-0246 73.2 µM 0.875411206563059 0.185324208330266 no 654 0.190675102178281 910 9561992
SGTC_925 2064-1272 59.6 µM 0.874579767854994 0.185547598196595 no 655 0.19090130012631 872 6815817
SGTC_3138 9097216 49.47 µM 0.873510510810996 0.185835130309037 no 656 0.191192439860353 1019 25237486
SGTC_2138 5575593 77.673 µM 0.866341950331948 0.187769945127165 no 657 0.193151333779782 957 762213
SGTC_839 0122-0028 230 µM 0.863141416526164 0.188637781170502 no 658 0.194029859477311 983 759448
SGTC_1762 st045503 25.4615 µM 0.862386460803178 0.188842849945552 no 659 0.194237444241064 968 4645554
SGTC_2607 solasodine 47.35 µM 0.86219572320992 0.188894681766138 no 660 0.194289911384213 960 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1666 st014829 29 µM 0.861939768039074 0.18896424985233 no 661 0.194360331811565 976 3858230
SGTC_3262 9137218 49.47 µM 0.861587969349838 0.189059893760958 no 662 0.194457146825917 831 17650664
SGTC_1152 3909-8331 15.9 µM 0.858594948337375 0.189874815212298 no 663 0.195282013065403 924 16001939
SGTC_1613 st002381 52.1 µM 0.857952155313923 0.190050112274189 no 664 0.195459441527602 1015 551167
SGTC_864 0469-0573 172 µM 0.857556997983054 0.190157925582371 no 665 0.195568564343556 910 689425
SGTC_3187 9109394 49.47 µM 0.857082456795426 0.190287447350101 no 666 0.195699657910965 962 17098090
SGTC_1199 1638-0010 4.46 µM 0.855764110195298 0.190647562564859 no 667 0.196064135360258 937 3111136
SGTC_1714 st033236 13.627 µM 0.852388543068195 0.191571526382309 no 668 0.196999238449738 980 2916566
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.851496379748356 0.191816187824065 no 669 0.19724683675317 1011 3256 An antibiotic and ribosome inhibitor.
SGTC_2879 9041815 71.43 µM 0.851057973886499 0.191936483649499 no 670 0.19736857462666 899 4942971
SGTC_2477 5967686 25.23 µM 0.850783486847613 0.192011824676834 no 671 0.197444818149377 964 776118
SGTC_505 gw-5074 63.9 µM 0.850663851786447 0.192044667694517 no 672 0.197478054428965 978 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1157 4092-0394 27.6 µM 0.849749889861316 0.192295688071894 no 673 0.197732077351394 1041 3659885
SGTC_610 4215-0184 155 µM 0.848018180211054 0.192771853512342 no 674 0.198213922992488 989 5605015
SGTC_606 k015-0008 38.6 µM 0.846376753347421 0.193223858431975 no 675 0.198671301294412 1052 1970475
SGTC_1424 4048-1941 275 µM 0.846241118650813 0.193261237501672 no 676 0.198709123912147 1062 X1424
SGTC_553 k007-0256 45.7 µM 0.845632785281834 0.193428940146172 no 677 0.19887881503075 996 6287000
SGTC_1075 aripiprazole 15.2 µM 0.845521177407378 0.193459717345511 no 678 0.198909956889604 1028 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2291 7917025 104.35 µM 0.841823488585557 0.194481087433576 no 679 0.199943381117664 943 2964612
SGTC_1904 st060225 78 µM 0.841357384682364 0.194610066493011 no 680 0.200073875843401 952 66595
SGTC_1785 bathophenanthroline 24 µM 0.840500574293903 0.194847296576763 no 681 0.200313889860771 939 72812 An iron chelator.
SGTC_2161 5662504 8.5105 µM 0.839263668752694 0.195190075875921 no 682 0.200660683001957 932 2859334
SGTC_2616 abietic acid 100 µM 0.839011692202994 0.195259950160193 no 683 0.200731374228359 1027 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2915 7971052 15.16 µM 0.837204433406299 0.195761556847986 no 684 0.201238832946044 847 5741558
SGTC_2614 arthonioic acid 13.39 µM 0.836414108681259 0.19598115792821 no 685 0.201460989090114 975 6710684
SGTC_232 clozapine 119 µM 0.835907801762448 0.196121919804108 no 686 0.201603386518024 965 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2848 9016370 25.97 µM 0.833763131154328 0.196718854098285 no 687 0.20220723755356 1025 7894410
SGTC_2384 9036245 200 µM 0.830310986159644 0.197682010813296 no 688 0.203181489103307 1006 6462766
SGTC_518 1021-0119 62.6 µM 0.829736906071351 0.19784245646919 no 689 0.203343775150273 910 1097762
SGTC_2473 5854593 8.94 µM 0.82460279196059 0.199280849513729 no 690 0.204798567898051 960 2872951
SGTC_1124 fisetin 1.16336 µM 0.82168494578429 0.200101123730858 no 691 0.205628114633886 953 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_652 0437-0092 114 µM 0.821395295332281 0.200182661777074 no 692 0.205710571245808 998 3091274
SGTC_259 usnic acid 108.925 µM 0.820091258466201 0.200550001903743 no 693 0.206082042578201 1043 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1984 st072354 53.1 µM 0.818620747648411 0.200964722067315 no 694 0.206501412929073 1000 5762938
SGTC_218 alverine citrate 93.75 µM 0.817447071783893 0.201296096394811 no 695 0.206836492348416 981 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1855 st056195 39.6 µM 0.817057427118441 0.201406180616373 no 696 0.206947805348612 970 4028379
SGTC_511 blebbistatin 171 µM 0.814261314033053 0.202197209424346 no 697 0.207747633426004 1006 3476986 A myosin inhibitor.
SGTC_247 mechlorethamine 29.705 µM 0.814213713237735 0.202210691902979 no 698 0.207761265420576 976 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_152 4469-0003 551.229 µM 0.813616401889775 0.202379920451197 no 699 0.207932369342017 1035 697280
SGTC_934 2950-0684 338 µM 0.812163644095768 0.202791864987729 no 700 0.208348868857445 1056 1121253
SGTC_1719 st032227 49.2 µM 0.810976071641527 0.203128985328028 no 701 0.208689706137151 1054 3125804
SGTC_1511 0906-3109 28.5 µM 0.807669701358697 0.204069337021015 no 702 0.209640375013987 1127 2882180
SGTC_1579 chlormadinone acetate 49.4 µM 0.802874761699516 0.205437644738531 no 703 0.211023562448159 1058 45114258 A steroidal progestin.
SGTC_2082 5219693 150 µM 0.80111504351437 0.205941170143164 no 704 0.211532523992341 1067 2834649
SGTC_2307 7538926 6.34 µM 0.800678341336941 0.206066241299166 no 705 0.211658942153893 1029 96582
SGTC_3032 9089427 49.47 µM 0.799763350405628 0.206328439982879 no 706 0.211923960461062 1031 17173707
SGTC_2919 7978188 46.38 µM 0.799012565297119 0.206543731649651 no 707 0.212141563041837 1054 2980291
SGTC_1936 st074407 74.3 µM 0.798221054635367 0.206770845614742 no 708 0.21237111063883 1102 809813
SGTC_67 0335-0847 266 µM 0.797382744396774 0.207011549273624 no 709 0.21261438886835 1101 4552207 YOR254C SEC63
SGTC_3263 9137018 49.47 µM 0.796417409563338 0.207288930733764 no 710 0.212894731238033 1019 43844957
SGTC_485 niflumic acid 177 µM 0.795646285681419 0.207510665006473 no 711 0.213118827823513 1023 4488 A COX2 inhibitor.
SGTC_3119 9125183 49.47 µM 0.793361513890736 0.208168466482343 no 712 0.213783613427566 914 22695334
SGTC_1637 st007924 17.4 µM 0.793062789040384 0.208254562284074 no 713 0.213870620692798 1021 683336
SGTC_3055 9094636 49.47 µM 0.790887003097508 0.20888228132642 no 714 0.214504966667208 1056 25236176
SGTC_3153 9100258 49.47 µM 0.788510617617066 0.20956914575016 no 715 0.215199045245472 993 25236848
SGTC_2160 5660466 132.927 µM 0.787861953437988 0.209756864550854 no 716 0.215388728915283 1004 2859134
SGTC_1495 4469-0029 237 µM 0.782711060172698 0.211251002199674 no 717 0.216898402930193 1117 793680
SGTC_634 1611-4317 11.2 µM 0.782123047104323 0.211421964862869 no 718 0.217071131674341 1113 2843522
SGTC_184 1494-0393 24.714 µM 0.781167852029029 0.211699857017327 no 719 0.217351889434636 1072 3090647
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.780774274353973 0.211814421597633 no 720 0.217467633567907 1057 641818 YHR062C RPP1
SGTC_879 0831-1030 162 µM 0.780415394350112 0.21191891781697 no 721 0.217573204745919 1057 1549252
SGTC_2913 7966556 36.57 µM 0.779401107368104 0.212214413951195 no 722 0.217871735863518 1019 2976516
SGTC_3000 9075062 71.4286 µM 0.778831931178175 0.212380339692077 no 723 0.218039362687148 1006 17057871
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.778114315471363 0.212589646392661 no 724 0.218250812029758 1063 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1021 4476-0760 85.3 µM 0.776903469051063 0.21294308651186 no 725 0.218607862205005 1077 746768
SGTC_2298 7976326 193.81 µM 0.775111135200021 0.213466888910563 no 726 0.219136996160636 988 2235818
SGTC_1000 4048-0884 8.67 µM 0.774882797585198 0.21353367355121 no 727 0.2192044589797 1028 13040088
SGTC_1380 2291-0730 164 µM 0.772674518612126 0.214180183384338 no 728 0.219857515333445 1052 2999191
SGTC_1181 1222-0449 220 µM 0.772649985782389 0.21418737216272 no 729 0.219864776715661 1090 658318
SGTC_513 4245-1575 41.7 µM 0.772493797968316 0.214233142681329 no 730 0.219911009400952 1116 719745
SGTC_325 2810-4341 181 µM 0.771822107449452 0.214430045053518 no 731 0.220109898067639 1098 774970
SGTC_147 4466-0538 29.23 µM 0.771540324248638 0.214512679569098 no 732 0.220193365247567 1194 6742687 YHR072W ERG7
SGTC_200 k038-0079 37.545 µM 0.770286522377043 0.214880588440883 no 733 0.220564974683256 1050 3436683
SGTC_1096 rimcazole 32.2 µM 0.769667354089718 0.215062408960919 no 734 0.220748620009556 1000 18528119 A dopamine reuptake inhibitor.
SGTC_2239 6685329 187.64 µM 0.768981960000878 0.215263781005596 no 735 0.220952009991586 1041 805680
SGTC_683 panaxydol 45 µM 0.768632262029711 0.215366566076953 no 736 0.221055823813416 1087 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1903 st060211 78.3 µM 0.768419910169687 0.215428995548381 no 737 0.221118877712994 1106 688960
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.766777859644199 0.215912097456321 no 738 0.22160680112788 1032 279621
SGTC_2440 5628896 157.78 µM 0.766587945485478 0.215968011904019 no 739 0.221663272414271 1071 5522048
SGTC_2031 5180455 200 µM 0.765613369902495 0.216255077996865 no 740 0.221953193398683 1095 29949
SGTC_3318 9139014 38.6185 µM 0.765260260869026 0.216359142518313 no 741 0.222058291224555 1052 16643984
SGTC_3075 9116269 49.47 µM 0.763736054945802 0.216808672665139 no 742 0.222512275043898 1090 17015205 YNL244C SUI1
SGTC_2697 mebhydrolin 72.4 µM 0.763711564883398 0.216815899861853 no 743 0.222519573711834 1092 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_607 4491-0986 66.8 µM 0.762761627216149 0.217096340893298 no 744 0.222802784872265 1115 698981 YDR232W HEM1
SGTC_2252 omeprazole 400 µM 0.762271328621398 0.217241169034444 no 745 0.222949041142063 1020 4594 A proton pump inhibitor.
SGTC_2047 4141938 200 µM 0.762004778226863 0.21731992813471 no 746 0.223028576174385 1046 3807862
SGTC_2085 5307070 144.047 µM 0.760085928882488 0.217887387428011 no 747 0.223601611504364 1055 2840351
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.758336551170272 0.218405472887756 no 748 0.224124765553625 1164 6708561
SGTC_410 α-linolenic acid 100 µM 0.757386342504259 0.218687178229052 no 749 0.224409217994841 1112 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2011 4012611 177 µM 0.756131481574812 0.219059523131571 no 750 0.224785184269954 1137 2049887
SGTC_512 prima-1 270 µM 0.753152685937591 0.219944855851774 no 751 0.225679083740292 1104 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1309 pyrazolanthrone 13.4 µM 0.752417955451939 0.220163541550717 no 752 0.2258998760166 1129 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_324 1315-0088 19.6 µM 0.747898171813406 0.221511553214091 no 753 0.227260790188977 1052 6787421
SGTC_1447 4239-0816 81.9 µM 0.746407070666674 0.221957302426544 no 754 0.227710774652563 1091 1341554
SGTC_801 0866-0028 10.1 µM 0.74556414804188 0.222209511835456 no 755 0.227965373550432 1153 6849771
SGTC_821 1114-0266 29.2 µM 0.74311313853879 0.222943802524412 no 756 0.228706592906054 1095 3123235
SGTC_768 0384-0033 77.3 µM 0.741712886810804 0.223363919404566 no 757 0.229130655128102 1086 3965305 YMR134W ERG29
SGTC_2994 9053520 71.4286 µM 0.740643070607442 0.223685199207032 no 758 0.229454942861385 1111 4647384
SGTC_320 4092-0846 5.34 µM 0.740564111733527 0.223708921997312 no 759 0.22947888743581 1127 1359356
SGTC_2803 7707263 71.43 µM 0.739793391049289 0.223940556200392 no 760 0.22971268489798 1089 2199229
SGTC_197 4544-0043 41.561 µM 0.738939289823645 0.224197408908271 no 761 0.229971931535836 1153 896523
SGTC_1668 st014914 51.6 µM 0.738739716375485 0.224257450464903 no 762 0.23003253195986 1147 2839556
SGTC_2685 mycophenolic acid 18.85 µM 0.734536542830431 0.225524091816107 no 763 0.231310898482876 1110 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3248 9135562 49.47 µM 0.73451931063887 0.225529293119313 no 764 0.231316147679633 1167 17650701
SGTC_2226 7298446 200 µM 0.734030156189355 0.225676966067043 no 765 0.231465179532007 1118 3283010
SGTC_2771 fluoxetine 41.05 µM 0.733344050665316 0.225884189576194 no 766 0.231674307116095 1123 3386 A selective serotonin reuptake inhibitor.
SGTC_859 0439-0102 54.6 µM 0.732662280784154 0.22609021013562 no 767 0.231882217433543 1168 610143
SGTC_1115 galangin 695.678 nM 0.732228533313004 0.226221337325935 no 768 0.232014545716475 1201 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1076 itraconazole 331 nM 0.731277954396326 0.226508859231508 no 769 0.232304696644577 1171 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1596 piperlongumine 63 µM 0.731268453935449 0.226511733879867 no 770 0.232307597546011 1167 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3111 9122088 49.47 µM 0.731174937433648 0.226540031191448 no 771 0.232336153252498 1060 16876704
SGTC_2361 9034121 116 µM 0.730749110595643 0.226668908063316 no 772 0.232466206180111 1126 6496917
SGTC_54 0159-0055 9 µM 0.725858370813505 0.228152058209732 no 773 0.233962799501561 1161 3319099
SGTC_686 1319-0111 510 µM 0.724651876706189 0.228518773063632 no 774 0.234332812428135 1185 4562600
SGTC_674 0498-0004 451 µM 0.724617314572404 0.2285292831282 no 775 0.23434341686517 1118 4231473
SGTC_1381 2324-0066 62.1 µM 0.724053674735185 0.228700719747538 no 776 0.234516391673467 1121 10885928
SGTC_720 r052-1644 49.9 µM 0.722197298095053 0.22926586529698 no 777 0.235086592135971 1118 1422863 YOR257W CDC31
SGTC_2381 9035592 200 µM 0.721897003413125 0.22935735895275 no 778 0.235178901878304 1102 4749657
SGTC_80 0159-0065 512.242 µM 0.721721714810414 0.22941077526872 no 779 0.235232794353673 1092 1548079
SGTC_2296 7971656 126.45 µM 0.720346269524575 0.229830161505776 no 780 0.235655911559052 1181 666570
SGTC_2067 5224629 34.075 µM 0.719959067054382 0.22994830057192 no 781 0.235775099223843 1163 2835000
SGTC_3213 9129884 49.47 µM 0.719272555403911 0.230157845178222 no 782 0.23598650115222 1120 17190742
SGTC_350 k064-0020 19.8 µM 0.718543830005069 0.230380391555862 no 783 0.236211016471102 1172 2790705
SGTC_2472 5377652 49.4 µM 0.718370374779896 0.230433380989242 no 784 0.236264474169667 1167 1610903
SGTC_759 3486-0358 89.3 µM 0.718326329485932 0.230446837622247 no 785 0.23627804968466 1189 875103
SGTC_2802 7925815 54.55 µM 0.717949678777265 0.230561929156453 no 786 0.236394157432795 1152 1262923
SGTC_2921 7974240 10.71 µM 0.717542129597643 0.230686498378187 no 787 0.23651982542962 1155 2979074 YDR527W RBA50
SGTC_3240 9133527 49.47 µM 0.716481262260408 0.23101093346034 no 788 0.236847116747008 1135 17617455
SGTC_3128 9127691 49.47 µM 0.715335383804737 0.231361652641794 no 789 0.237200914669123 1080 41316314
SGTC_3330 9141424 71.43 µM 0.714119138560304 0.231734233641337 no 790 0.237576756213928 1176 27261020
SGTC_1154 4088-0362 150 µM 0.713494002874184 0.231925865869094 no 791 0.237770061411132 1201 6618304
SGTC_2930 9013230 14.89 µM 0.713306298095592 0.231983423055999 no 792 0.237828120541519 1148 2995857
SGTC_2286 7945697 125 µM 0.713260805732848 0.231997373884456 no 793 0.237842192994738 1148 1245733
SGTC_1811 st050069 61.5 µM 0.713207391913293 0.232013754527531 no 794 0.237858716427363 1159 3877702
SGTC_137 0438-0332 85.389 µM 0.712713239524085 0.232165328873631 no 795 0.238011611090139 1217 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_745 0469-0705 296 µM 0.712403004439285 0.232260517308581 no 796 0.238107627803553 1245 3486736
SGTC_2024 5144227 134 µM 0.712102067271446 0.232352873639006 no 797 0.238200787121693 1170 3475211
SGTC_3180 9109287 49.47 µM 0.710311917276526 0.232902685030479 no 798 0.238755365640269 1158 18891271
SGTC_2432 5630864 12.22 µM 0.708952642239815 0.233320643421791 no 799 0.239176932849697 1144 5714970
SGTC_2434 5670830 169.91 µM 0.707960049324358 0.233626114846932 no 800 0.239485033610573 1151 1549830
SGTC_3162 9099653 49.47 µM 0.707300062176917 0.23382934920492 no 801 0.239690013458414 1155 25237511
SGTC_2461 5755302 26.15 µM 0.706798116183683 0.233983982438734 no 802 0.239845972713064 1170 2788904
SGTC_1405 3909-7894 12 µM 0.706683466735435 0.234019310149979 no 803 0.239881603119625 1175 7104060
SGTC_1674 st016616 23.6 µM 0.706335782355434 0.23412646255674 no 804 0.239989673064335 1177 625830
SGTC_3132 9126706 49.47 µM 0.705728952895811 0.234313545628851 no 805 0.240178356072685 1195 850858
SGTC_1319 1306-0155 43.7 µM 0.705680948010039 0.234328348872097 no 806 0.240193285802593 1219 3122360
SGTC_1933 st074711 15.9 µM 0.7050909346162 0.234510333285017 no 807 0.240376823858379 1196 17250958
SGTC_1554 st069299 38.7 µM 0.704615424913845 0.234657056926216 no 808 0.24052479832645 1179 24207999
SGTC_84 0443-0269 128.823 µM 0.702312696414448 0.23536830627409 no 809 0.241242088537262 1151 6150058
SGTC_1971 st069429 63.5 µM 0.701547707838592 0.23560485320395 no 810 0.241480636251565 1180 1246522 YGL099W LSG1
SGTC_210 3551-0445 56.827 µM 0.700599935277079 0.235898101713676 no 811 0.241776359414276 1210 2865180 YOR207C RET1
SGTC_2399 5884133 200 µM 0.698942672046705 0.236411355505026 no 812 0.242293929182616 1213 722445
SGTC_57 miconazole 162.5 nM 0.698764620790314 0.236466534456777 no 813 0.24234957098291 1140 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_422 cantharidin 155 µM 0.698621046364962 0.236511034032555 no 814 0.2423944436641 1183 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.69787228903518 0.236743179166669 no 815 0.242628532852346 1222 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2639 lactacystin 53 µM 0.697406555803892 0.23688763854771 no 816 0.242774199982092 1211 3870 A proteasome inhibitor.
SGTC_3269 9137823 49.47 µM 0.697263514162049 0.236932016391782 no 817 0.242818948538287 1139 17682936
SGTC_2776 terbinafine 19.92 µM 0.69589847282088 0.237355742411065 no 818 0.24324620689466 1212 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1587 estradiol valerate 56.1 µM 0.694522003461999 0.237783436833664 no 819 0.243677453394745 1206 13791 A steroid.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.693928274845488 0.23796804967258 no 820 0.243863595339716 1238 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1195 1502-0147 41.1 µM 0.693686192686536 0.238043344780176 no 821 0.243939513384099 1221 817940
SGTC_794 k038-0031 316 µM 0.690883581558419 0.238915994299118 no 822 0.244819352370972 1237 6624242
SGTC_1361 1608-0041 5.61 µM 0.690558534473389 0.239017317359264 no 823 0.244921506600283 1202 X1361
SGTC_2053 5265679 138 µM 0.686694697832145 0.24022354269255 no 824 0.246137569452435 1198 764595
SGTC_1982 st072467 71.9 µM 0.685571740467372 0.240574732391578 no 825 0.246491603479555 1185 3163533
SGTC_1399 3562-5772 25 µM 0.68508307136027 0.240727644274242 no 826 0.246645751023715 1163 23847490
SGTC_39 0986-0283 58.349 µM 0.685030185981024 0.24074419607287 no 827 0.246662436473852 1236 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2728 chlorpromazine 9.18 µM 0.682706155882 0.241472170522957 no 828 0.247396269544575 1213 2726 A thorazine and dopamine antagonist.
SGTC_458 nppb 133 µM 0.68238782510795 0.24157197682171 no 829 0.247496876085991 1248 4549 A chloride channel blocker.
SGTC_3327 9140648 26.9345 µM 0.681853300744363 0.241739616704115 no 830 0.247665858481462 1207 8029710
SGTC_65 0798-0905 34.986 µM 0.680787348650945 0.242074113713526 no 831 0.24800302819757 1330 3602145
SGTC_1622 st003707 19.4 µM 0.680684308368774 0.242106461172251 no 832 0.248035633692596 1240 10140899
SGTC_284 0988-0104 32.6 µM 0.679621545875984 0.242440231146382 no 833 0.248372061760828 1237 4666532
SGTC_858 0438-0351 2.77 µM 0.679265795647253 0.242552013317526 no 834 0.248484732358075 1229 2799119
SGTC_1987 st072290 61.9 µM 0.676891672548648 0.243298713347217 no 835 0.249237344026173 1228 54697379
SGTC_2745 rifampicin 24.3 µM 0.676620450477049 0.243384096070205 no 836 0.249323400178691 1146 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1327 1436-0082 2.18 µM 0.67643990341919 0.2434409426005 no 837 0.249380694778669 1210 15992205
SGTC_2415 st077333 57.7 µM 0.675587983010871 0.243709272578867 no 838 0.249651136635907 1270 2766255
SGTC_3152 9099253 49.47 µM 0.675440765502684 0.24375565795778 no 839 0.249697886566547 1240 25236131
SGTC_3209 9113616 49.47 µM 0.674490759476595 0.244055100986682 no 840 0.249999679274407 1250 16649353
SGTC_2249 haloperidol 116.36 µM 0.674339469583465 0.244102806048697 no 841 0.250047758078242 1242 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_961 1252-1571 372 µM 0.674219079544567 0.24414077129352 no 842 0.250086020642837 1237 6813498
SGTC_1735 st034310 56.75 µM 0.67324435867149 0.244448268730416 no 843 0.250395922412899 1268 871153
SGTC_975 1335-0046 28.5 µM 0.671559958146932 0.24498014195077 no 844 0.250931938448838 1210 16486740
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.671311033676848 0.245058796134588 no 845 0.251011203567811 1210 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1371 2421-0008 32.7 µM 0.670954287360112 0.245171543124813 no 846 0.251124825536243 1213 2827552
SGTC_2269 7935389 174.42 µM 0.670223987951235 0.245402435732053 no 847 0.251357507174073 1210 97605
SGTC_1098 clofazimine 15.1 µM 0.670154594302173 0.245424381414826 no 848 0.251379622701824 1279 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1737 st035557 69.7 µM 0.670137224066883 0.245429874902059 no 849 0.251385158699635 1168 5716916
SGTC_1003 4049-0218 100 µM 0.669522799386404 0.245624234523472 no 850 0.251581020965474 1264 295161
SGTC_2991 9074669 71.4286 µM 0.665498003435232 0.246899431215705 no 851 0.252866010069312 1250 17333109
SGTC_406 estrone 100 µM 0.665355104579863 0.246944771634446 no 852 0.252911696543836 1265 5870 A steroid.
SGTC_3287 9117173 37.0625 µM 0.665317383138265 0.246956741024744 no 853 0.252923757264951 1218 2789709
SGTC_805 3852-0218 479 µM 0.66493412607281 0.247078369919875 no 854 0.253046313658785 1209 6615355
SGTC_2602 kawain 100 µM 0.664165173676576 0.247322498121238 no 855 0.253292300341358 1230 5369129
SGTC_2330 7979373 200 µM 0.663830902958109 0.247428663105692 no 856 0.253399272218103 1212 1863007
SGTC_2420 aureobasidin a 50 nM 0.662706313957022 0.247786013332585 no 857 0.253759332594398 1323 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_757 1066-0008 322 µM 0.661169961004365 0.24827465098287 no 858 0.254251661517896 1276 6842497
SGTC_2965 9082772 38.63 µM 0.659723484222097 0.248735172630349 no 859 0.254715646671073 1281 16459634
SGTC_2208 7283366 200 µM 0.658342216057696 0.249175357715635 no 860 0.255159128393561 1253 898663
SGTC_2358 9037157 4 µM 0.658123511307697 0.249245092922389 no 861 0.255229384614665 1274 2388925
SGTC_3291 9121177 71.43 µM 0.655759041226441 0.249999679274407 no 862 0.255989586945664 1212 17015612
SGTC_2902 5787006 60.46 µM 0.654374163769805 0.250442205120988 no 863 0.256435387752167 1231 591003
SGTC_2199 6590217 200 µM 0.652740018288029 0.250964915919972 no 864 0.256961949325443 1215 703109
SGTC_793 0488-0545 106 µM 0.652677008120817 0.250985082407937 no 865 0.25698226399702 1243 292548
SGTC_841 0251-0215 91.2 µM 0.65114306995333 0.251476285786251 no 866 0.257477068001696 1302 3888614
SGTC_728 3030-5151 22.5 µM 0.651107264642996 0.251487757560077 no 867 0.257488623665516 1283 3125388
SGTC_2032 5185112 25.99 µM 0.649614033372603 0.251966424674886 no 868 0.257970782993293 1205 5718189
SGTC_7 0192-1582 4.227 µM 0.646637746984751 0.252921929156057 no 869 0.258933211025646 1315 252616
SGTC_631 k072-0230 41.5 µM 0.645582644341662 0.253261115697873 no 870 0.259274840103395 1291 5773147
SGTC_1608 st001473 40.5 µM 0.64323784285667 0.25401576052712 no 871 0.260034890752426 1236 7292267
SGTC_1997 st073024 93.8 µM 0.642793601388801 0.254158866865716 no 872 0.26017901778966 1271 686268
SGTC_1094 duloxetine 25.4 µM 0.642415512768392 0.254280696264144 no 873 0.26030171501874 1272 60834 A selective serotonin reuptake inhibitor.
SGTC_1037 k284-1091 78.7 µM 0.642105832094602 0.254380505753107 no 874 0.260402234722018 1252 3334711
SGTC_3299 9121982 43.1275 µM 0.641887409433469 0.254450915305818 no 875 0.260473144875612 1285 17594604 YPL160W CDC60
SGTC_125 0133-0007 11.75 µM 0.641627062254291 0.254534852759172 no 876 0.260557678665526 1350 26541
SGTC_117 lucigenin 22.078 µM 0.64022979769874 0.254985586746868 no 877 0.261011606625994 1246 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2995 9067767 71.4286 µM 0.639201511576042 0.255317561071905 no 878 0.26134592445292 1282 11673567
SGTC_826 1683-5028 118 µM 0.63617188099515 0.256296966007169 no 879 0.262332199284022 1302 722377
SGTC_1860 st056228 74.6 µM 0.636060878286527 0.2563328876028 no 880 0.262368371598952 1260 688679
SGTC_712 r015-0009 80.6 µM 0.632572566055856 0.257463076135208 no 881 0.263506403456319 1269 6813872 YLR060W FRS1
SGTC_2371 9071574 200 µM 0.632251991063967 0.257567069900009 no 882 0.263611114548234 1270 45596039
SGTC_2156 5649887 115 µM 0.631811833939477 0.25770989135535 no 883 0.263754919956902 1335 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2699 st077704 54.6 µM 0.631450589030638 0.257827138215395 no 884 0.263872973540067 1304 645852
SGTC_1705 st027868 56.3335 µM 0.630423601910662 0.258160611754711 no 885 0.264208736454659 1308 292948
SGTC_1775 st081588 35.1725 µM 0.630190036565081 0.258236484083086 no 886 0.264285128610051 1309 1426443 YGL099W LSG1
SGTC_3270 9137563 49.47 µM 0.629425694397139 0.258484856917751 no 887 0.264535200398666 1298 17015724
SGTC_2932 9016711 44.54 µM 0.62929298631475 0.25852799298587 no 888 0.264578631105576 1292 7117328
SGTC_2326 6164455 177.58 µM 0.62816790813149 0.258893843490585 no 889 0.264946975463453 1299 2888790
SGTC_1273 0849-0096 14.1 µM 0.627812206575351 0.259009565459927 no 890 0.265063484374686 1295 5286025
SGTC_1800 st050079 29.0735 µM 0.626934296608036 0.259295294264063 no 891 0.265351152333541 1271 3645560
SGTC_1436 4092-1007 8.32 µM 0.62636202033197 0.259481637711174 no 892 0.265538757462514 1267 2881121
SGTC_1707 st032323 6.317 µM 0.623775240445734 0.26032480181484 no 893 0.266387601098131 1252 3132057 YMR211W DML1
SGTC_1838 st055369 84.5 µM 0.623593022476746 0.260384249159924 no 894 0.266447447069662 1269 676036
SGTC_1779 st039427 55 µM 0.623419328519912 0.26044092211428 no 895 0.266504499825021 1401 1124498
SGTC_2 0422-0095 29 µM 0.622052070700295 0.260887253419369 no 896 0.266953814718974 1194 6790840
SGTC_1974 st069448 26.9 µM 0.621662894632025 0.261014368988543 no 897 0.267081777565137 1290 6323587 YNR016C ACC1
SGTC_1908 st060353 56.5 µM 0.620883589054579 0.261269007241195 no 898 0.267338109818725 1362 4227716
SGTC_3194 9111903 49.47 µM 0.620527861991855 0.261385283540674 no 899 0.267455158206938 1349 17087251
SGTC_429 1112-0049 25.5 µM 0.619937815491331 0.261578210285338 no 900 0.267649364006444 1281 2836170
SGTC_1334 1486-0610 236 µM 0.618741203733071 0.261969689189526 no 901 0.268043430642969 1314 3742339
SGTC_583 1488-1091 88.9 µM 0.616050810230678 0.262850963595863 no 902 0.268930492849086 1389 4303273
SGTC_1830 st055982 50.3 µM 0.615995334798875 0.262869151255412 no 903 0.268948799409832 1289 455313 An antimicrobial agent.
SGTC_2907 7721985 69.9 µM 0.614437329910754 0.263380206942158 no 904 0.269463187078306 1272 3267881
SGTC_2279 7948423 32.93 µM 0.613693206890558 0.263624472535544 no 905 0.269709039082613 1402 1247112
SGTC_149 3970-0822 46.1 µM 0.613458380709262 0.263701580490017 no 906 0.269786646998001 1377 3114250 YBL034C STU1
SGTC_466 geldanamycin 89.2 µM 0.613054937431137 0.263834082717561 no 907 0.269920007433067 1237 5288382 HSP90 inhibitor.
SGTC_761 k216-0224 480 µM 0.612721732970683 0.26394354211306 no 908 0.270030174907753 1368 1340404
SGTC_2310 7668677 200 µM 0.611084938764968 0.264481573424524 no 909 0.270571675091583 1372 2197143
SGTC_290 2043-6722 48.1 µM 0.610725572170851 0.264599775644442 no 910 0.270690636824449 1323 773758 YLR208W SEC13
SGTC_539 4859-0462 2.54 µM 0.609677222234483 0.264944750514651 no 911 0.271037823041086 1319 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1300 1094-0077 113 µM 0.609639926908763 0.264957027295553 no 912 0.271050178372717 1294 5532636
SGTC_591 4299-0174 154 µM 0.609083125334522 0.265140348195516 no 913 0.271234671029164 1321 5509088
SGTC_2997 9067075 71.4286 µM 0.608681563901687 0.265272597926595 no 914 0.2713677646954 1346 27209819
SGTC_3199 9111318 49.47 µM 0.607405499823535 0.265693077424115 no 915 0.271790919735243 1338 8548020
SGTC_1980 st071811 45.7 µM 0.606692006480625 0.265928329853481 no 916 0.272027663990258 1371 4974850
SGTC_1426 4048-4480 71.7 µM 0.605718603397374 0.266249449626826 no 917 0.272350814203262 1360 14224343
SGTC_255 tunicamycin 200.472 nM 0.605166903821144 0.266431539079604 no 918 0.272534051982032 1321 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.604051772412261 0.266799782503336 no 919 0.272904611005815 1318 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2595 hexamethylquercetagetin 100 µM 0.603446658691022 0.266999713316611 no 920 0.273105795286792 1322 386331
SGTC_2204 7233102 200 µM 0.602548767429608 0.26729651779867 no 921 0.273404455732704 1300 2172480
SGTC_1392 3455-1037 33.9 µM 0.600866850357024 0.267852935339438 no 922 0.273964337025671 1359 981132
SGTC_3063 1327-0034 4 µM 0.599783392022763 0.268211677438787 no 923 0.274325301547282 1245 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_130 0136-0219 337.655 µM 0.599385359720032 0.268343529952437 no 924 0.274457968770975 1321 234244
SGTC_726 3448-4391 34.2 µM 0.598369637185078 0.268680146730142 no 925 0.274796660319042 1441 1356692
SGTC_2753 fluvastatin 17.09 µM 0.598185093507121 0.268741328422705 no 926 0.274858218313839 1370 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3059 1327-0034 3 µM 0.597454300563202 0.268983676630729 no 927 0.27510205469384 1292 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1942 st076330 65.2 µM 0.596447501306647 0.269317734638228 no 928 0.275438157732417 1372 24208414
SGTC_515 4092-1064 102 µM 0.59641930398593 0.269327093559747 no 929 0.275447573842192 1425 717353
SGTC_563 tetrahydrosecaminediol 614 µM 0.596373161896813 0.269342408848548 no 930 0.275462982703644 1392 334274 A psychoactive constituent of the cannabis plant.
SGTC_1892 st058411 7.36 µM 0.596143682333601 0.269418583229163 no 931 0.275539622263356 1389 3934738
SGTC_981 1488-1094 54.9 µM 0.596071081926109 0.269442684752708 no 932 0.275563870890321 1307 3449522
SGTC_3062 9077494 49.47 µM 0.594427046682255 0.269988752605272 no 933 0.276113261500823 1357 16459633
SGTC_543 3844-1095 191 µM 0.59351894895135 0.270290615380642 no 934 0.276416952729305 1386 4230703
SGTC_2571 chrysanthemic acid 100 µM 0.592712893280959 0.270558699416846 no 935 0.276686655637023 1287 2743 An insecticide.
SGTC_1287 0971-0001 34.6 µM 0.590995935224289 0.271130180639606 no 936 0.27726157224202 1362 4665869
SGTC_2717 st081029 62.2815 µM 0.589949590923842 0.271478746251781 no 937 0.277612222792444 1317 5292846
SGTC_737 1950-0117 57.9 µM 0.58974032689876 0.271548484539618 no 938 0.277682377271937 1326 5393513
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.589361693110036 0.271674688823342 no 939 0.277809333929286 1318 688667
SGTC_449 xestospongin c 11.1929 µM 0.585323058025021 0.27302264008826 no 940 0.279165256752967 1366 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2791 5663188 71.43 µM 0.584469958908 0.273307797475235 no 941 0.279452085467157 1408 54690634
SGTC_2212 7123476 200 µM 0.584016856071629 0.273459311839142 no 942 0.27960448573384 1349 1085715
SGTC_1383 3049-0032 20.7 µM 0.581899502480573 0.27416789050385 no 943 0.28031718782302 1426 712864
SGTC_1271 0832-2808 169 µM 0.581710630340835 0.274231141156114 no 944 0.280380804978547 1389 3663794
SGTC_1059 3448-6867 171 µM 0.580202466744405 0.274736462526235 no 945 0.280889045181733 1349 3934407
SGTC_1727 st034309 9.9045 µM 0.579544790966857 0.274956965328683 no 946 0.281110816513229 1486 870305
SGTC_402 epigallocatechin gallate 10 µM 0.578912527034036 0.275169030330819 no 947 0.281324098561108 1364 65064 An antioxidant.
SGTC_1688 st021091 57.6 µM 0.575309201071042 0.276379141917844 no 948 0.282541099917856 1395 3656366
SGTC_750 4073-0104 132 µM 0.57526678822721 0.276393401029567 no 949 0.282555439655869 1257 22330957
SGTC_2202 7226349 200 µM 0.573932847127398 0.276842053354128 no 950 0.28300662220115 1340 844334
SGTC_50 0929-0078 56.389 µM 0.573813906509613 0.276882074670941 no 951 0.283046868598718 1400 1377751
SGTC_208 k072-0098 12.366 µM 0.57201105366037 0.277489047998969 no 952 0.283657243051818 1366 5948901
SGTC_2115 tiliquinol 12.7705 µM 0.571713998877519 0.277589120933141 no 953 0.283757874484975 1403 71208 A bioactive hydroxyquinoline.
SGTC_3348 9149464 3.537 µM 0.570906383363397 0.277861282596468 no 954 0.284031551840415 1367 1951442
SGTC_1607 st000305 50.6 µM 0.570431689640719 0.278021312341441 no 955 0.284192470607849 1426 5457690
SGTC_2738 aclarubicin 5.55 µM 0.570424887517977 0.278023605814124 no 956 0.284194776809771 1363 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2567 aureobasidin a 60 nM 0.570369455602486 0.278042296144999 no 957 0.284213570863332 1461 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2023 5144124 124 µM 0.569407027652002 0.278366901769603 no 958 0.284539974362487 1364 2830192
SGTC_687 k029-0044 34.9 µM 0.566889751019339 0.279216795693703 no 959 0.28539454390802 1439 5829338
SGTC_2008 4012253 172 µM 0.566686956804967 0.279285318817369 no 960 0.285463442014062 1389 603940
SGTC_1018 4259-0013 28.1 µM 0.565292942680531 0.279756570053284 no 961 0.285937264061441 1408 6801262
SGTC_3328 9140624 29.0385 µM 0.563251339462957 0.280447436487944 no 962 0.286631874030879 1446 4904392
SGTC_72 0744-0168 198.391 µM 0.56301804432292 0.280526434732218 no 963 0.286711298418665 1426 677577
SGTC_2842 9000675 19.48 µM 0.562786654285424 0.280604798508506 no 964 0.286790084527579 1333 2989072
SGTC_1678 st019265 80.2 µM 0.560746934330273 0.281296038693159 no 965 0.287485033334041 1487 5367020
SGTC_2456 5770359 74.46 µM 0.559870487761468 0.28159330973869 no 966 0.287783890054211 1456 3118787
SGTC_387 norethindrone acetate 66.7 µM 0.556147562175441 0.282857728598436 no 967 0.289054991545048 1402 541197
SGTC_2760 etidronate 98.04 µM 0.555573379799457 0.283052980849409 no 968 0.289251266812505 1373 3305 A chelator and antioxidant.
SGTC_1504 k297-0033 30 µM 0.554979274747447 0.283255075929789 no 969 0.289454418253522 1311 4388117
SGTC_3050 9093513 49.47 µM 0.554408569101311 0.28344927644884 no 970 0.289649631465253 1391 25236664
SGTC_1848 st056003 16.4 µM 0.553498565745845 0.28375906561826 no 971 0.289961031213914 1436 146492
SGTC_1845 st056753 3.01 µM 0.553162608724888 0.283873475219676 no 972 0.290076034112382 1338 5375839
SGTC_183 3914-0051 30.55 µM 0.551710071266772 0.284368388363399 no 973 0.290573504348521 1483 1596232
SGTC_998 3996-0085 177 µM 0.550726767209203 0.28470365669625 no 974 0.290910496268639 1491 715391
SGTC_3238 9133470 49.47 µM 0.549298336736376 0.285191031641099 no 975 0.291400364310674 1482 3534688
SGTC_2201 6605497 169.863 µM 0.548295821254807 0.285533323314884 no 976 0.291744398115571 1444 670741
SGTC_2262 9014885 67.46 µM 0.547108228602853 0.285939059270522 no 977 0.292152189702347 1382 6457424
SGTC_1597 7-benzyloxygramine 47.5 µM 0.546759889938515 0.28605811964877 no 978 0.292271851356374 1409 260807
SGTC_427 1354-0053 47.3 µM 0.546569039042186 0.286123361498626 no 979 0.292337422316901 1498 6813657
SGTC_1133 3473-0247 50 µM 0.544759618302617 0.286742257895965 no 980 0.292959427627632 1360 711311
SGTC_848 0368-0089 85.6 µM 0.544746458484423 0.286746761419345 no 981 0.292963953686895 1376 762535
SGTC_1356 1502-0781 85.8 µM 0.5432079198087 0.287273507638668 no 982 0.293493327137855 1400 567702
SGTC_1929 genistein trimethyl ether 50.5 µM 0.541472682456079 0.287868146041504 no 983 0.294090910840921 1532 136420
SGTC_2338 7999974 200 µM 0.540981604936294 0.288036536013416 no 984 0.29426013090902 1474 315925
SGTC_571 k831-0106 44.2 µM 0.540498282571257 0.288202312133091 no 985 0.294426722535956 1493 4783639
SGTC_2223 6903751 107.57 µM 0.539431664587046 0.28856831365808 no 986 0.294794518561521 1427 5598863
SGTC_949 1165-0505 146 µM 0.538959815668616 0.288730294717678 no 987 0.29495729118572 1410 6244267
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.538049058606832 0.289043069611424 no 988 0.295271589983121 1407 4620898
SGTC_2128 5255449 168.493 µM 0.537947679141208 0.289077895503632 no 989 0.295306585183009 1396 736008
SGTC_2176 5809774 33.9695 µM 0.537589778784432 0.289200857276919 no 990 0.295430144145932 1437 2870539
SGTC_56 0957-0365 83.25 µM 0.537437564029396 0.289253160278944 no 991 0.295482700887536 1384 6752360
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.535657957438374 0.28986498623367 no 992 0.296097482575355 1456 66535 A nucleotide analog.
SGTC_2620 irigenin 100 µM 0.534776553117347 0.290168236258453 no 993 0.296402189113491 1531 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1814 st052110 31.539 µM 0.532950571058843 0.290796943846508 no 994 0.297033898496599 1485 674163
SGTC_1391 3442-0225 151 µM 0.532253720773933 0.291037045576271 no 995 0.297275140240583 1441 5227075
SGTC_3271 9137798 49.47 µM 0.532143510331128 0.291075027374927 no 996 0.297313302056706 1470 6498326
SGTC_3127 9126946 49.47 µM 0.531768299311489 0.291204353614928 no 997 0.297443240588592 1380 27243249
SGTC_3150 9097574 49.47 µM 0.530951999213999 0.291485805312261 no 998 0.29772602129172 1502 17217476
SGTC_2890 9046729 58.44 µM 0.530820531644333 0.291531145808984 no 999 0.297771575433854 1372 903329
SGTC_2140 5586273 200 µM 0.53058761923346 0.291611480646712 no 1000 0.29785228850395 1428 854421
SGTC_3064 1327-0027 10 µM 0.530304330649312 0.291709204858777 no 1001 0.297950472291772 1369 16000455 YPR107C YTH1
SGTC_3319 9138450 16.7555 µM 0.528599965992704 0.292297470294299 no 1002 0.298541491947844 1427 2029690
SGTC_596 1155-0152 116 µM 0.525829226691867 0.293254973196386 no 1003 0.2995034329108 1432 280313
SGTC_1389 3405-0187 19 µM 0.523337450003051 0.294117312832659 no 1004 0.300369722026339 1393 799890
SGTC_1996 st072960 66.8 µM 0.523258535072135 0.29414464238916 no 1005 0.300397176016557 1437 1719405
SGTC_1966 st070145 16.1 µM 0.52274813316021 0.294321431414856 no 1006 0.300574768888291 1377 3748532
SGTC_3117 9124945 49.47 µM 0.521908331696048 0.294612422023543 no 1007 0.300867078503315 1345 17592065
SGTC_2182 6325192 200 µM 0.521241265365099 0.294843654570868 no 1008 0.301099355545303 1410 736248
SGTC_1772 st048439 82.2 µM 0.519176053208465 0.295560071676238 no 1009 0.301818988323763 1429 2927068 YDL195W SEC31
SGTC_620 0109-0052 432 µM 0.518966943426323 0.295632655955373 no 1010 0.301891896678854 1492 493037
SGTC_343 4130-2827 29.8 µM 0.518443146363308 0.295814507569225 no 1011 0.302074558837973 1437 1118244
SGTC_2532 xanthone 78.9 µM 0.515009067500235 0.297008020139323 no 1012 0.303273341866622 1503 7020 An insecticide.
SGTC_2101 5377231 179.231 µM 0.514533666113624 0.297173419095786 no 1013 0.303439464480161 1544 2844213
SGTC_1404 3909-7820 48.3 µM 0.514345413798025 0.297238926410448 no 1014 0.303505257951448 1500 23741373
SGTC_274 sirtinol 40.1 µM 0.51333009419475 0.297592347135825 no 1015 0.303860218104571 1418 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1683 st010134 710 nM 0.513017338173195 0.297701252430944 no 1016 0.3039695962645 1434 3818134
SGTC_2294 7971431 200 µM 0.511357586748013 0.29827950130046 no 1017 0.304550344021877 1476 5741572
SGTC_1829 berberine 14.4 µM 0.509492098371269 0.298930037576642 no 1018 0.305203667750018 1560 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1306 1185-0270 9.02 µM 0.508905491083007 0.299134733377048 no 1019 0.305409235431698 1516 1548076
SGTC_2861 9024595 19.48 µM 0.508443783564836 0.299295890306381 no 1020 0.305571077039922 1447 16482810
SGTC_2967 9089538 49.85 µM 0.508153348478891 0.299397285540481 no 1021 0.305672902262875 1605 728216
SGTC_489 paxilline 115 µM 0.506755490760256 0.299885516336157 no 1022 0.306163194960581 1413 105008 A toxic potassium channel blocker.
SGTC_2300 7976697 71.57 µM 0.504204035428406 0.300777592933571 no 1023 0.307059002475801 1403 2236109
SGTC_566 0958-0068 16.5 µM 0.502120474171478 0.301506964482567 no 1024 0.307791389470676 1485 6815365
SGTC_1471 k673-0312 37 µM 0.501787576795567 0.301623572252063 no 1025 0.307908476418609 1465 24099884
SGTC_2784 7567673 72.73 µM 0.500733467823903 0.301992940781328 no 1026 0.308279357504843 1473 3471247
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.498926610911703 0.302626550545898 no 1027 0.308915543160911 1508 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1122 capsaicin 818.572 nM 0.498253943761277 0.302862586529096 no 1028 0.30915253268825 1574 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_446 go6976 132 µM 0.497720621442936 0.303049785574525 no 1029 0.309340485655495 1537 3501 A protein kinase C inhibitor.
SGTC_1826 st055655 41.6 µM 0.495603764338939 0.303793323937759 no 1030 0.31008699820561 1500 676168
SGTC_1749 st037932 54.2 µM 0.495128574721588 0.303960344360982 no 1031 0.310254682256205 1471 594497
SGTC_273 hydroxyurea 18.1 mM 0.495013316359241 0.304000861727479 no 1032 0.310295360365126 1515 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2297 7971671 152.32 µM 0.494945757495239 0.30402461216257 no 1033 0.310319204979342 1575 909016
SGTC_1841 st054148 70 µM 0.494567539382017 0.304157590666551 no 1034 0.310452710180894 1441 675442
SGTC_1088 bifonazole 369 nM 0.494234014571841 0.304274876855515 no 1035 0.310570460053981 1453 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_613 3914-0030 117 µM 0.493288272839617 0.30460756262184 no 1036 0.310904456691808 1417 1145395
SGTC_102 gallobenzophenone 83.616 µM 0.493003141068693 0.304707895821187 no 1037 0.311005183959813 1571 70837
SGTC_119 0121-0043 24.815 µM 0.491673133335467 0.305176097749628 no 1038 0.311475217016656 1507 1092378
SGTC_2918 7977171 22.06 µM 0.490577115540453 0.305562168131401 no 1039 0.311862787679769 1469 2236483
SGTC_1161 k007-0610 110 µM 0.489870109948295 0.305811324426898 no 1040 0.312112907586873 1545 5843850
SGTC_1257 0669-0121 16 µM 0.48886892117197 0.306164307804344 no 1041 0.31246724993217 1599 4307855
SGTC_2767 sibutramine 71.45 µM 0.487363804837215 0.306695296725568 no 1042 0.313000269467962 1609 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2270 7924575 90.91 µM 0.486951089295011 0.306840969313489 no 1043 0.313146496271922 1628 1262135
SGTC_792 4534-1957 155 µM 0.485087393558803 0.307499161327674 no 1044 0.31380717702996 1521 1717904
SGTC_1709 st033179 39.1045 µM 0.483973295975292 0.307892917934268 no 1045 0.314202410484228 1492 573381
SGTC_92 0063-0024 660.874 µM 0.483223091896079 0.308158188019746 no 1046 0.314468670442257 1511 3594437
SGTC_1540 guanosine 70.6 µM 0.480729550256595 0.309040617140481 no 1047 0.315354363101702 1499 6802 Guanosine is a purine nucleoside
SGTC_1885 st057546 99.9 µM 0.480180986426463 0.309234894326376 no 1048 0.315549352749672 1581 702008
SGTC_1913 st060213 96.1 µM 0.480028081985672 0.309289055865601 no 1049 0.315603712524142 1589 688959
SGTC_3317 9138495 8.753 µM 0.479204275701886 0.309580934351021 no 1050 0.315896656392559 1496 17020139
SGTC_867 0518-0118 155 µM 0.478996815176963 0.309654457545907 no 1051 0.315970447179036 1531 6848158
SGTC_2586 curcumin 80 µM 0.478117479237722 0.30996617528455 no 1052 0.316283295970201 1585 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_8 0354-0001 70 µM 0.477381918777179 0.310227030715502 no 1053 0.316545093600517 1548 4993152
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.476962382283386 0.310375855793426 no 1054 0.31669445447382 1516 688662
SGTC_1206 3978-0017 132 µM 0.476191477873616 0.310649404980267 no 1055 0.316968985160601 1588 3873677
SGTC_2886 9058944 51.95 µM 0.475599229064305 0.310859630814226 no 1056 0.317179962365577 1456 4949929
SGTC_3101 9120531 49.47 µM 0.474480539279894 0.311256891644804 no 1057 0.317578636120181 1575 24824904
SGTC_3283 9109332 35.8195 µM 0.473718084929061 0.311527774852017 no 1058 0.317850477574571 1462 17027281
SGTC_1220 1838-0075 193 µM 0.473639625614898 0.3115556555083 no 1059 0.317878456619571 1535 5529645
SGTC_2829 7992743 58.44 µM 0.473053284609573 0.311764047024509 no 1060 0.318087582122259 1636 16462845
SGTC_2046 4110841 106 µM 0.471776938835695 0.312217881593062 no 1061 0.318543006555763 1541 44119630 YMR134W ERG29
SGTC_2957 9076800 11.52 µM 0.470178878179577 0.312786511312202 no 1062 0.319113611653063 1481 16459615
SGTC_1132 3456-3614 2.5 µM 0.469618950313595 0.312985853102672 no 1063 0.319313641567289 1730 3125502
SGTC_1374 2889-5571 141 µM 0.467597936525301 0.313705815545411 no 1064 0.320036070417015 1511 2853281
SGTC_1408 3909-7976 48.8 µM 0.467555220086706 0.313721040447233 no 1065 0.3200513471563 1557 24152374
SGTC_928 2764-0428 58.7 µM 0.467167967197484 0.313859078766951 no 1066 0.320189854863599 1566 662578
SGTC_2643 anethole 100 µM 0.467006397770253 0.313916678739731 no 1067 0.320247650379216 1516 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1143 3454-2408 5.08 µM 0.466903788400001 0.313953261634441 no 1068 0.320284357368973 1501 X1143
SGTC_2746 daunorubicin 9.88 µM 0.466323471891692 0.314160193888354 no 1069 0.320491990135673 1543 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_657 3534-0529 86.7 µM 0.465224683908479 0.314552165403508 no 1070 0.320885281884335 1622 1049549
SGTC_1747 st037496 66.6 µM 0.464943217140761 0.314652606930428 no 1071 0.320986060310845 1515 723305
SGTC_1780 st038448 24.544 µM 0.464942110791406 0.314653001758699 no 1072 0.320986456462312 1638 728868 YDL195W SEC31
SGTC_2328 6201408 200 µM 0.463641775657514 0.315117205079934 no 1073 0.32145220935151 1504 2890418
SGTC_24 0417-1663 219 µM 0.463636385402932 0.315119129941614 no 1074 0.321454140613141 1524 4329390
SGTC_3215 9129942 49.47 µM 0.461326429157851 0.315944477546573 no 1075 0.322282213044291 1585 17682944
SGTC_2983 9022671 12.99 µM 0.45988138556476 0.316461259010157 no 1076 0.322800680980807 1674 6405161
SGTC_942 3253-1115 227 µM 0.459420547345935 0.316626141018047 no 1077 0.322966097888503 1627 46497897
SGTC_1350 1495-0454 146 µM 0.459106054322676 0.316738683514342 no 1078 0.323079004605681 1604 1069057
SGTC_2070 5230947 200 µM 0.458402872757337 0.316990381006142 no 1079 0.323331514075504 1598 2835538
SGTC_430 0958-0115 16.4 µM 0.456473451997782 0.317681434560804 no 1080 0.32402477858934 1553 6833180
SGTC_1545 lovastatin 49.4 µM 0.456258772746927 0.317758364782185 no 1081 0.324101953275882 1581 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2640 pentamidine 10.38 µM 0.454278223255598 0.318468464647219 no 1082 0.324814293927769 1631 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2830 7992007 71.43 µM 0.452580208959038 0.319077796777016 no 1083 0.325425526256813 1544 1952075
SGTC_1251 0490-5699 265 µM 0.45250717761558 0.319104015045299 no 1084 0.325451825818703 1661 3883818
SGTC_2986 9022445 71.43 µM 0.451885857714663 0.319327105612495 no 1085 0.325675606550459 1656 6459286
SGTC_3095 9117207 49.47 µM 0.451498512817399 0.319466218438564 no 1086 0.325815148329847 1641 17015229
SGTC_334 1502-1024 68.5 µM 0.451475955586561 0.31947432052931 no 1087 0.325823275369883 1560 3296216
SGTC_3061 glucosamine 200 µM 0.449908618490755 0.320037486444675 no 1088 0.326388166463224 1615 91431 and experimental redox chemotherapeutic
SGTC_305 1682-2595 20.8 µM 0.448563505665821 0.320521135040708 no 1089 0.326873282474146 1576 226033
SGTC_2912 7964298 10.93 µM 0.446335071473496 0.321323061326846 no 1090 0.327677613035229 1543 2975850
SGTC_987 1497-1013 404 µM 0.445159280940868 0.32174651858867 no 1091 0.328102325396238 1589 1676435
SGTC_636 0kpi-0074 126 µM 0.442495527532881 0.322706717225637 no 1092 0.329065333002058 1557 616434
SGTC_1940 st075990 51.1 µM 0.442108553913603 0.322846307538777 no 1093 0.329205327404273 1644 1084979
SGTC_3202 9113761 49.47 µM 0.441176391981908 0.323182662315556 no 1094 0.329542651422465 1723 4798415
SGTC_1480 1070-0044 41.2 µM 0.440905722117238 0.323280356035345 no 1095 0.329640625479945 1615 3124987
SGTC_333 3486-0131 40.1 µM 0.44055958609255 0.323405305749623 no 1096 0.329765932972785 1681 6744690
SGTC_2174 5790901 200 µM 0.440265116082053 0.323511620519098 no 1097 0.329872551480006 1564 786020
SGTC_2345 9052315 157.45 µM 0.440098817630971 0.323571666893011 no 1098 0.329932769127437 1581 6469265
SGTC_955 1216-0110 33 µM 0.439124184693042 0.323923675743302 no 1099 0.330285778011906 1502 3619719
SGTC_349 k015-0014 24 µM 0.439107925433577 0.323929549447953 no 1100 0.330291668345136 1520 2196908
SGTC_2220 6782180 200 µM 0.43857179287997 0.324123253437708 no 1101 0.330485919644456 1592 833803
SGTC_2895 9054447 58.44 µM 0.437051467455789 0.324672803876748 no 1102 0.331037011533473 1576 2697450
SGTC_630 4356-0227 183 µM 0.436548053439964 0.324854856636655 no 1103 0.331219571256239 1572 779312
SGTC_251 melphalan 456.522 µM 0.436435942382911 0.324895405757312 no 1104 0.331260233044785 1662 460612 A DNA alkylator.
SGTC_1873 rapamycin 2 nM 0.433946222272843 0.325796439232599 no 1105 0.332163746674977 1568 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1572 epiandrosterone 68.9 µM 0.429238157208553 0.327503075998989 no 1106 0.333874958544912 1632 441302 A steroid.
SGTC_1353 1498-1206 8.11 µM 0.429120160456078 0.327545895427328 no 1107 0.333917890704842 1565 6756808
SGTC_3173 9105693 49.47 µM 0.426206521459518 0.328603934057786 no 1108 0.334978682945059 1644 17096658
SGTC_1413 3910-0535 34.4 µM 0.42496824273239 0.329054011044274 no 1109 0.33542991271413 1669 2876951
SGTC_2952 9073731 13.78 µM 0.423953946296258 0.329422861978331 no 1110 0.335799700136363 1528 16457353
SGTC_3035 9091303 49.47 µM 0.4237280989447 0.329505014435507 no 1111 0.335882060162071 1594 25237002
SGTC_2661 dactinomycin 12.96 µM 0.422632601486644 0.329903620689566 no 1112 0.336281668319289 1595 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.422534755084581 0.329939232358053 no 1113 0.336317369076792 1673 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3336 9143619 71.43 µM 0.421273512517762 0.33039840553326 no 1114 0.336777684768952 1638 45595730
SGTC_1460 k062-0059 9.15 µM 0.420818927711217 0.330563966223731 no 1115 0.336943654593043 1543 1373085
SGTC_3289 9119912 71.43 µM 0.419385180400664 0.331086356951964 no 1116 0.337467326481421 1605 17014829
SGTC_2504 purpurogallin 52.29 µM 0.419315686453837 0.331111685675824 no 1117 0.33749271694684 1575 5281571 An antioxidant.
SGTC_995 3931-2021 34.6 µM 0.419143055178818 0.331174608599365 no 1118 0.337555793101137 1632 730143
SGTC_3231 9132313 49.47 µM 0.418357280324079 0.331461078396632 no 1119 0.337842957796075 1625 4905967
SGTC_2682 pyrogallin 40.03 µM 0.41790143282919 0.331627311852031 no 1120 0.338009592446321 1635 822798 An ATP competetive kinase inhibitor.
SGTC_2214 7179297 48.276 µM 0.417827066834444 0.331654433973254 no 1121 0.338036779882963 1648 769744
SGTC_1357 1503-1303 39.5 µM 0.416185335948283 0.332253416423642 no 1122 0.338637194635518 1588 292895
SGTC_1492 4158-0558 28.5 µM 0.416063633393508 0.332297836462031 no 1123 0.33868172011799 1706 3967268
SGTC_871 0574-0004 149 µM 0.415859552959698 0.332372328769957 no 1124 0.338756389015595 1603 9551173
SGTC_654 1124-0271 80.9 µM 0.415179589171865 0.332620573154111 no 1125 0.339005219713584 1561 5403748
SGTC_148 3253-0744 288.01 µM 0.415066601873109 0.332661830205622 no 1126 0.339046573884548 1563 6893655
SGTC_346 4513-0042 7.16 µM 0.414218279069418 0.332971658025272 no 1127 0.339357128100084 1575 2827372
SGTC_384 k007-0144 5.16 µM 0.413696625496869 0.333162235062495 no 1128 0.339548149370388 1623 6824886
SGTC_1798 st045719 60.953 µM 0.413621500434393 0.333189684244838 no 1129 0.339575662374808 1620 3980186
SGTC_289 k017-0060 526 µM 0.412904574516755 0.333451679446725 no 1130 0.339838264693754 1596 5512909
SGTC_1448 4255-0083 152 µM 0.411742020407783 0.333876698817675 no 1131 0.340264261074773 1746 5399660
SGTC_1804 st050076 49.1 µM 0.410259406553383 0.334419038452925 no 1132 0.340807833265997 1642 3895976
SGTC_1258 0671-0043 57.1 µM 0.409077916607836 0.33485147469552 no 1133 0.341241240941508 1561 4298767
SGTC_2337 9009472 200 µM 0.408637226249248 0.335012827570051 no 1134 0.341402953705111 1706 5742383
SGTC_2207 7258803 200 µM 0.407913807590135 0.335277763647901 no 1135 0.341668477673382 1669 3666799
SGTC_868 0527-0199 213 µM 0.407868193798861 0.335294471437644 no 1136 0.341685222411112 1618 2849450
SGTC_3186 9110464 49.47 µM 0.405593505934795 0.336128075217821 no 1137 0.342520650616407 1670 17018021
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.405564514623347 0.336138704863556 no 1138 0.3425313032855 1674 676296 Flavone; oxidizing agent.
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.405238493667354 0.336258249257606 no 1139 0.342651106190579 1717 165506
SGTC_3100 9120536 49.47 µM 0.402617209185427 0.337220014954123 no 1140 0.343614923833407 1680 16421196
SGTC_141 0443-0274 32.331 µM 0.400710867345735 0.337920132917064 no 1141 0.344316504410807 1710 1627241
SGTC_601 0986-0029 62.9 µM 0.40049644656485 0.337998915661842 no 1142 0.344395450102605 1624 24747981
SGTC_2475 5812728 15.03 µM 0.399259230316648 0.338453633670714 no 1143 0.344851102140824 1583 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3170 9103054 49.47 µM 0.399126907324546 0.338502280720477 no 1144 0.344899848463228 1584 16432970
SGTC_1634 st006576 41 µM 0.398648833790457 0.338678061495571 no 1145 0.345075986898484 1763 3915356
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.397448276907543 0.339119643904266 no 1146 0.345518460536369 1601 91467 include heat shock
SGTC_570 0987-0065 62.6 µM 0.394599208004722 0.340168457192781 no 1147 0.346569349060159 1688 3104428
SGTC_2891 9063876 19.48 µM 0.394302813991915 0.340277638441715 no 1148 0.346678742985038 1720 6472478
SGTC_1879 gemcitabine 100 µM 0.391796894466638 0.34120126650508 no 1149 0.347604144925845 1673 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2651 TUB2.036 5 µM 0.391347690112593 0.341366934376198 no 1150 0.347770126194961 1710 15992207 YFL037W TUB2
SGTC_1783 st039459 87.517 µM 0.390732743913491 0.341593777893769 no 1151 0.347997396484195 1774 729761
SGTC_2588 indole-3-carbinol 100 µM 0.39022800918748 0.341780008980645 no 1152 0.348183975903981 1773 3712 Induces cell cycle arrest.
SGTC_3023 9089636 49.47 µM 0.386584738101095 0.343125400168745 no 1153 0.349531829192069 1716 17249241
SGTC_1466 k213-0079 57.5 µM 0.386343002974115 0.343214739005145 no 1154 0.349621328143847 1643 3657981
SGTC_129 0088-0017 176.636 µM 0.38571815644667 0.343445706157337 no 1155 0.349852707295056 1748 182446
SGTC_2178 5812956 200 µM 0.385376246864437 0.343572113760882 no 1156 0.349979339196357 1664 5403383
SGTC_612 0302-0167 22.4 µM 0.383107373715361 0.344411382927474 no 1157 0.350820076270841 1744 235821
SGTC_2703 st077852 53.4 µM 0.381347789334041 0.345062791364597 no 1158 0.351472598566213 1665 6281836
SGTC_2821 7996764 71.43 µM 0.380518687930585 0.345369888913743 no 1159 0.351780213517904 1681 2987135
SGTC_2906 7926292 26.41 µM 0.378244797292083 0.346212655670352 no 1160 0.352624374834784 1635 2966319
SGTC_968 1309-0633 340 µM 0.377658513464468 0.34643007242191 no 1161 0.35284214533292 1756 3761976
SGTC_1732 st034308 51.822 µM 0.377395744630376 0.34652753371143 no 1162 0.352939764395297 1621 830119
SGTC_2896 9052656 71.43 µM 0.377278155331406 0.346571151020714 no 1163 0.35298345215286 1655 6469436
SGTC_3313 9133968 57.047 µM 0.377149263021292 0.346618963284186 no 1164 0.353031341526035 1668 1494643
SGTC_3210 9128157 49.47 µM 0.376769084024046 0.346760003912988 no 1165 0.353172608924805 1592 17590849
SGTC_2423 st077119 87.2 µM 0.376677410773153 0.346794016474498 no 1166 0.35320667601762 1629 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1066 ketoconazole 628 nM 0.376010604913548 0.347041451573758 no 1167 0.35345450600672 1737 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1354 1498-1681 81 µM 0.374789596854271 0.347494706371208 no 1168 0.35390847589488 1675 5754243
SGTC_2191 5911152 200 µM 0.374733214770148 0.34751564144139 no 1169 0.353929443735432 1667 2875902
SGTC_1863 st057641 20.1 µM 0.373986183597862 0.347793063329629 no 1170 0.354207297727921 1740 3921635
SGTC_2439 5492030 7.2 µM 0.373933201945566 0.34781274200475 no 1171 0.354227006901895 1769 5722370
SGTC_938 3126-1755 342 µM 0.3733787725688 0.348018695152888 no 1172 0.3544332780368 1765 1777771
SGTC_2019 4016004 108 µM 0.371790818518793 0.348608818297022 no 1173 0.355024300110825 1627 45595336
SGTC_1519 esterone 74 µM 0.370812262056553 0.348972656799764 no 1174 0.355388683836401 1582 698 A steroid.
SGTC_1751 st044839 27.194 µM 0.368700208400888 0.349758415590848 no 1175 0.356175596697366 1706 5291326
SGTC_205 1486-1330 71.903 µM 0.367965588900095 0.350031871196792 no 1176 0.356449446438081 1699 4118834
SGTC_584 0986-0246 15.4 µM 0.36634734765213 0.350634521420542 no 1177 0.35705295161905 1717 53315 YDR232W HEM1
SGTC_3226 9131256 49.47 µM 0.36449949044258 0.351323142954451 no 1178 0.357742527116779 1653 17178073
SGTC_1611 st001856 99.4 µM 0.363838548164032 0.351569568065323 no 1179 0.357989287664823 1638 647478
SGTC_1956 st077085 54 µM 0.363832536838613 0.351571809608812 no 1180 0.35799153224517 1650 24208685
SGTC_3036 9090181 49.47 µM 0.362160525301644 0.352195480631586 no 1181 0.358616038171098 1700 25236586
SGTC_1457 k015-0032 57.3 µM 0.361930859429413 0.35228117857936 no 1182 0.358701849277766 1661 4302660
SGTC_3177 9107506 49.47 µM 0.361858395920674 0.35230821930376 no 1183 0.358728925629394 1775 8897194
SGTC_507 nimesulide 162 µM 0.36177962517948 0.352337614502955 no 1184 0.358758359515275 1791 4495 A COX2 inhibitor.
SGTC_2127 5253358 187.912 µM 0.361587663120179 0.35240925346236 no 1185 0.358830092571813 1629 20612
SGTC_2210 7115885 190.385 µM 0.357129997833711 0.35407429223288 no 1186 0.360497244122464 1708 2927039
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.356074844970848 0.354468825838818 no 1187 0.360892257531777 1774 6710655
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.355987324397198 0.354501557793921 no 1188 0.360925028935357 1834 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2390 9097792 176.6 µM 0.354300098112518 0.355132775942257 no 1189 0.361556997114385 1629 4497149
SGTC_1575 cyproterone acetate 48 µM 0.354283942003013 0.355138822124645 no 1190 0.361563050382586 1625 9880 An androgen receptor antagonist and liver toxin.
SGTC_676 falcarinol 140 µM 0.353410651646572 0.355465692212408 no 1191 0.361890300767486 1819 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2689 tacrolimus 100 µM 0.349408232901769 0.356965143402665 no 1192 0.363391426700077 1680 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3297 9117502 71.43 µM 0.349000739208881 0.357117929783859 no 1193 0.363544377305541 1727 7453720
SGTC_1681 tripelennamine 100 µM 0.348548839998586 0.357287392441771 no 1194 0.363714020724954 1645 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2583 asiatic acid 100 µM 0.348481677344758 0.357312580908069 no 1195 0.363739235934612 1733 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1411 3909-8223 150 µM 0.345355532520188 0.358485686533567 no 1196 0.364913551416631 1803 X1411
SGTC_846 0335-0850 148 µM 0.345148906231953 0.358563271569972 no 1197 0.364991214009292 1728 6819598
SGTC_190 3970-0790 3.722 µM 0.34277109523033 0.359456522933262 no 1198 0.365885336351801 1794 2832352
SGTC_2319 6033012 152.6 µM 0.342685364327378 0.359488743091349 no 1199 0.365917587172854 1630 847246
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.341340033581373 0.35999448808649 no 1200 0.366423806600466 1827 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2655 perillic acid 100 µM 0.340656505657376 0.360251538090343 no 1201 0.366681092791575 1706 5702197 An apoptosis inducer.
SGTC_93 0109-0045 59.227 µM 0.339241163404193 0.360783997629312 no 1202 0.367214030977623 1796 88733
SGTC_974 1326-0144 138 µM 0.338168416930802 0.361187750674635 no 1203 0.367618137451858 1693 5411856
SGTC_159 3970-0959 50 µM 0.337561876701735 0.361416104660393 no 1204 0.367846687697727 1780 6615653
SGTC_234 nsc-17383 10.7 µM 0.334831824258589 0.362444541804307 no 1205 0.368875976261872 1828 408974
SGTC_2068 5226020 147 µM 0.334361436651626 0.362621841900692 no 1206 0.369053417775965 1687 1810509
SGTC_1255 0566-0045 221 µM 0.333112698365854 0.363092663416162 no 1207 0.369524607179155 1782 2788469
SGTC_1433 4060-0023 7.6 µM 0.33155527985597 0.36368015902612 no 1208 0.370112546275521 1781 3840627
SGTC_1047 2043-3044 82 µM 0.328666562470892 0.364770700631846 no 1209 0.371203865365729 1667 669592
SGTC_681 1642-0006 26.6 µM 0.328125999036358 0.364974894729379 no 1210 0.371408198442203 1710 4446530
SGTC_1268 0828-0275 2.46 µM 0.326442208721147 0.365611180081254 no 1211 0.372044903537804 1800 745337
SGTC_694 1315-0438 43.2 µM 0.323548662524134 0.366705481859136 no 1212 0.373139880086026 1786 6793154
SGTC_2098 5376439 882.5 nM 0.321854855516009 0.367346561520542 no 1213 0.373781327424249 1854 2844116
SGTC_2520 obtusaquinone 4.71 µM 0.320994143381694 0.36767246957221 no 1214 0.37410741457996 1831 5967872
SGTC_2827 7993847 71.43 µM 0.320253056302387 0.367953158053529 no 1215 0.374388253097705 1765 2985692
SGTC_167 3672-0051 66.205 µM 0.319786971109457 0.36812972505459 no 1216 0.374564912480744 1686 3237971
SGTC_1665 st014639 11.4 µM 0.319582179218191 0.36820731515602 no 1217 0.374642542690343 1813 981133 YIL048W NEO1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.319170992070273 0.368363119060941 no 1218 0.374798426234605 1823 5377381
SGTC_2146 5545642 200 µM 0.318188862340589 0.368735347748417 no 1219 0.375170840328175 1768 825326
SGTC_453 enantio-paf c16 10 µM 0.315097430185549 0.369907807948213 no 1220 0.376343839814326 1758 13871343 A lipid and platelet activating factor
SGTC_831 k061-1017 217 µM 0.313620441950797 0.370468400174766 no 1221 0.376904665945793 1870 1240153
SGTC_3204 9114183 49.47 µM 0.313517451926191 0.370507500408871 no 1222 0.37694378191719 1685 17027248
SGTC_2411 st077133 39.94 µM 0.313107828942258 0.370663027295512 no 1223 0.37709937065662 1904 1403142 YNL221C POP1
SGTC_3116 9124943 49.47 µM 0.311043732438609 0.371447050805111 no 1224 0.377883687865175 1661 41905195 YPL160W CDC60
SGTC_393 acivicin 6.25 µM 0.3108466846261 0.3715219251239 no 1225 0.377958588652816 1763 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2009 4012297 12.05 µM 0.309602572905963 0.371994775406053 no 1226 0.378431599738326 1736 45595307
SGTC_1773 st048542 73.5835 µM 0.309198579366946 0.372148363042964 no 1227 0.378585237246952 1693 3237138
SGTC_1662 st014054 52 µM 0.308327921827822 0.372479433096929 no 1228 0.378916410871741 1800 2838777
SGTC_2370 9071495 200 µM 0.307399025932746 0.372832752372514 no 1229 0.379269834757565 1733 21791103
SGTC_1970 st070122 35.8 µM 0.306458870905193 0.373190463189039 no 1230 0.379627645261749 1841 102928
SGTC_1648 st011736 69.8 µM 0.30638817524318 0.373217365945468 no 1231 0.379654555262488 1857 2855514
SGTC_2248 tofa 1.1 µM 0.306144045191963 0.373310272738565 no 1232 0.37974748680123 1796 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2247 cerulenin 830 nM 0.305913489493064 0.373398020402381 no 1233 0.379835257449152 1848 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_459 nigericin 15.3 µM 0.305831412807405 0.373429259720465 no 1234 0.379866504859053 1791 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_270 tamoxifen 5.46 µM 0.305406435870888 0.373591024065779 no 1235 0.380028310342924 1907 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2648 atorvastatin 78.68 µM 0.305141569381615 0.373691854816266 no 1236 0.380129166089154 1854 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2116 5511452 16.8835 µM 0.304340182440934 0.3739969835866 no 1237 0.380434367476237 1799 870744
SGTC_1799 st045822 46.1415 µM 0.304239407318762 0.374035359394958 no 1238 0.380472752095837 1881 3674992
SGTC_1261 0712-0010 12.7 µM 0.303935483295141 0.37415110315763 no 1239 0.380588521998563 1893 2840123
SGTC_1239 0337-0584 35.4 µM 0.301109663876841 0.375227805336188 no 1240 0.381665436051687 1916 914301 YML130C ERO1
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.301018227480693 0.37526266099926 no 1241 0.381700297630295 1857 140250 A respiratory chain inhibitor.
SGTC_2774 tamoxifen 10.92 µM 0.300747770563444 0.375365765458738 no 1242 0.38180341924214 1784 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1781 st038725 66.3 µM 0.300647628362714 0.375403944251073 no 1243 0.381841604254666 1740 4270275 YIL048W NEO1
SGTC_166 k072-0058 166.424 µM 0.300222968943963 0.375565857422254 no 1244 0.382003543017348 1900 5846229
SGTC_1116 jasmonic acid 1.58368 µM 0.299088445470362 0.375998533364448 no 1245 0.382436281094038 1848 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_904 1141-0088 396 µM 0.298458474735338 0.376238854183648 no 1246 0.382676632496035 1720 1378119
SGTC_842 0271-0008 11.1 µM 0.298351329709185 0.376279732575237 no 1247 0.382717515810678 1852 1221709
SGTC_891 0929-0073 133 µM 0.298051002732188 0.376394321900043 no 1248 0.382832118503325 1855 5603632
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.297501295589901 0.37660409008136 no 1249 0.383041909505133 1840 6708630 An antioxidant.
SGTC_2110 5483698 200 µM 0.296725230433153 0.376900298482838 no 1250 0.383338146496333 1796 2848765 YHR062C RPP1
SGTC_1828 st055811 49 µM 0.295696078437091 0.377293216771049 no 1251 0.383731096146864 1924 5877589
SGTC_2811 7967822 32.47 µM 0.294975049428508 0.377568572999446 no 1252 0.384006469897913 1854 2232244
SGTC_468 gf-109203x 121 µM 0.294894565964035 0.377599312968235 no 1253 0.384037211595149 1883 2396 A protein kinase C inhibitor.
SGTC_1765 st044815 90.4 µM 0.293751463135457 0.378035994907106 no 1254 0.384473913150518 1722 645695
SGTC_2564 betulinic acid 100 µM 0.293712204718394 0.3780509949662 no 1255 0.384488913719617 2002 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_303 1348-1668 34.2 µM 0.292773723918958 0.378409629242789 no 1256 0.384847556951833 1817 5380509
SGTC_2701 st077767 14.721 µM 0.292460068122378 0.37852951411955 no 1257 0.384967443436569 1786 5721188
SGTC_1165 k072-0275 30.3 µM 0.291338089028638 0.378958450311326 no 1258 0.38539637969908 1883 6153523 YGL055W OLE1
SGTC_1330 1469-0054 61.8 µM 0.289535313016159 0.379647969410482 no 1259 0.386085880314075 1941 7102664
SGTC_2782 7736369 71.43 µM 0.289306033715197 0.379735690798928 no 1260 0.38617359770825 1751 2950836 YOL077C BRX1
SGTC_37 0566-0070 1.56 µM 0.288553651209839 0.380023592941985 no 1261 0.386461484138691 1886 1626686
SGTC_633 0437-0093 97.7 µM 0.286291447706713 0.380889634037391 no 1262 0.387327453933391 1790 2831118
SGTC_1553 gossypol 38.6 µM 0.285063321847315 0.381360048743346 no 1263 0.387797814808665 1830 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2141 5621638 7.665 µM 0.282229629673531 0.382446118852889 no 1264 0.388883720105342 1924 2856238
SGTC_164 4100-3994 89.624 µM 0.281640536027507 0.382672017425058 no 1265 0.389109577300694 1954 4615967
SGTC_852 0418-0143 439 µM 0.28037468025865 0.383157567602345 no 1266 0.389595030281914 1915 5369229
SGTC_1481 3346-2004 36 µM 0.279984419942746 0.383307298631396 no 1267 0.389744729065233 1826 2770522
SGTC_799 1310-0557 151 µM 0.277586547948598 0.384227671108235 no 1268 0.390664879825726 1836 5354492
SGTC_579 4491-1009 110 µM 0.277171992802293 0.38438685570513 no 1269 0.390824021977489 2007 1271041
SGTC_2691 st077356 60.2 µM 0.276948069381549 0.384472847937891 no 1270 0.390909990778903 1897 2839272
SGTC_2981 9013952 38.96 µM 0.276682485481662 0.384574846213885 no 1271 0.391011960805483 1697 2996344
SGTC_1689 st020265 53.493 µM 0.276104188061425 0.384796970669947 no 1272 0.39123402202775 1933 5758320 YPR016C TIF6
SGTC_1455 4262-0120 131 µM 0.275993516080102 0.384839484171292 no 1273 0.391276523158653 1900 1529587
SGTC_2164 5685496 200 µM 0.274808925680836 0.385294618998251 no 1274 0.391731520163292 1908 759046
SGTC_369 0957-0393 4.5 µM 0.273090443419498 0.385955162711025 no 1275 0.392391846334806 1750 6997992
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.271301138258065 0.386643280570934 no 1276 0.393079715542322 1793 2724 A muscle relaxant with antifungal properties.
SGTC_3351 9150312 21.596 µM 0.270801102636117 0.386835644442591 no 1277 0.393272005887063 1896 4904905
SGTC_1248 0469-0687 58.6 µM 0.270422105500528 0.386981463293655 no 1278 0.393417767833679 1877 4017482
SGTC_2402 5553605 200 µM 0.269872816986118 0.387192829930226 no 1279 0.393629050198416 1880 6758546
SGTC_2898 9056270 58.44 µM 0.267563805885791 0.388081704322361 no 1280 0.394517547057045 1850 19154699
SGTC_1938 st074717 56.4 µM 0.267322768632411 0.388174527655952 no 1281 0.394610328811454 1807 17250979
SGTC_1419 3993-2473 62.6 µM 0.266101150321918 0.388645070429452 no 1282 0.39508065455081 1858 704026
SGTC_2899 9053889 58.44 µM 0.265755356321396 0.388778293024032 no 1283 0.395213813799129 1975 6470052
SGTC_764 1951-2361 146 µM 0.265104401003756 0.38902911930985 no 1284 0.395464518547014 1760 5438930
SGTC_2442 5158906 48.48 µM 0.263620519804129 0.389601061581266 no 1285 0.396036172592367 1929 1893835
SGTC_1101 ebselen 5.29 µM 0.263239159393957 0.389748090562608 no 1286 0.396183124989809 1972 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_112 phenothiazine 287.218 µM 0.263108036578563 0.389798647054695 no 1287 0.396233654913083 1976 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1484 3473-2379 286 µM 0.26256727568149 0.390007165732755 no 1288 0.396442062737658 1950 671917
SGTC_740 k014-0057 261 µM 0.26154192010669 0.390402632134543 no 1289 0.396837313282087 1953 4012779
SGTC_3216 9129716 49.47 µM 0.261371320073635 0.390468441380286 no 1290 0.396903085893541 1800 8056934
SGTC_342 k048-0088 23.3 µM 0.260102176159693 0.390958114141006 no 1291 0.39739247967623 1790 6820570
SGTC_2474 5321570 43.32 µM 0.260016098365071 0.390991331737035 no 1292 0.397425677939554 1940 2841384
SGTC_2075 5212009 200 µM 0.259270103503117 0.391279245960329 no 1293 0.39771342242642 1939 780898
SGTC_1525 8-methoxypsoralen 92.5 µM 0.258387280452124 0.391620045534019 no 1294 0.398054016059863 1999 4114 Related to psoralen; DNA damaging agent.
SGTC_2518 prenyletin 46.28 µM 0.258231092201363 0.391680348153334 no 1295 0.398114281672117 1966 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_614 0462-0418 107 µM 0.255935552908155 0.392566930929056 no 1296 0.399000300699001 1886 5188303
SGTC_1006 4099-6547 255 µM 0.255885524785615 0.39258625900883 no 1297 0.399019616078868 1908 3146833
SGTC_632 0781-2353 4.65 µM 0.255797238518102 0.39262036855092 no 1298 0.39905370316596 1899 6811515 YHR007C ERG11
SGTC_2570 licareol 100 µM 0.255389713636123 0.392777827133903 no 1299 0.399211057385388 1813 443158
SGTC_2052 5265182 7.135 µM 0.255297527233293 0.392813448351721 no 1300 0.39924665483265 1944 1239884
SGTC_312 4092-0653 6.84 µM 0.255129010066042 0.392878566421528 no 1301 0.39931172929487 1930 1148278
SGTC_3218 9131285 49.47 µM 0.255066406174806 0.392902758456986 no 1302 0.399335905079155 1967 17156417
SGTC_1850 st056238 17 µM 0.25444616416372 0.393142461051596 no 1303 0.399575445173584 1947 5393177
SGTC_2092 5303694 80.6725 µM 0.253897444021949 0.393354556641617 no 1304 0.399787394740321 1815 1963699
SGTC_1763 st044482 94.5 µM 0.252558546086149 0.393872210643953 no 1305 0.400304683530412 1923 88505
SGTC_1435 4092-0789 56.7 µM 0.252444442433081 0.393916334876224 no 1306 0.400348776054079 1947 2248285
SGTC_2150 5556613 200 µM 0.25191411132005 0.39412143340872 no 1307 0.400553726006545 1889 743190
SGTC_1963 st076565 50.3 µM 0.251589422722437 0.39424701691898 no 1308 0.400679217571951 1822 4914280
SGTC_2866 9034245 58.44 µM 0.25138193396617 0.394327275469373 no 1309 0.400759416976755 1998 6462273
SGTC_559 1550-0661 158 µM 0.249730610037299 0.394966182361846 no 1310 0.401397842333067 1904 5830875
SGTC_1469 k284-2957 126 µM 0.249072312748713 0.39522096029814 no 1311 0.401652422947268 1918 23884841
SGTC_1920 st075728 45.7 µM 0.243807761943931 0.397260079523593 no 1312 0.403689854273872 2008 3400306
SGTC_3183 9108214 49.47 µM 0.243273546152182 0.397467155447352 no 1313 0.403896748006449 1977 4974831
SGTC_2684 capsaicin 100 µM 0.242946893156268 0.397593788879322 no 1314 0.404023269044879 1907 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_42 0133-0086 60.653 µM 0.242836858443225 0.397636448421802 no 1315 0.404065890557793 1822 162923 Model of phenazepam hydroxylation.
SGTC_3122 9126309 49.47 µM 0.241848175691257 0.398019807353696 no 1316 0.404448903961142 2021 17591206
SGTC_365 0121-0052 13.6 µM 0.24122414632821 0.398261823685235 no 1317 0.404690698660515 1920 3101739
SGTC_1909 st060837 51.5 µM 0.241137254878618 0.398295525766837 no 1318 0.404724369663961 1837 678937
SGTC_2780 5215298 71.43 µM 0.239043172851646 0.399107974100312 no 1319 0.405536052933775 2048 2834131
SGTC_576 1073-0113 22.7 µM 0.238215966936549 0.399429028747273 no 1320 0.405856796857247 2012 5439563
SGTC_2016 5121758 140 µM 0.236469134015654 0.400107231712423 no 1321 0.406534327832417 1935 2795203
SGTC_2485 5633444 17.78 µM 0.236418693745343 0.400126819492036 no 1322 0.40655389588908 1809 5724239
SGTC_2834 9001755 58.44 µM 0.236329589867335 0.400161422361558 no 1323 0.406588463873806 1849 2989575
SGTC_2927 9011802 47.9 µM 0.236166016240019 0.400224947078799 no 1324 0.406651924405369 1803 43912568
SGTC_1236 0330-0013 258 µM 0.235814068596561 0.400361636829099 no 1325 0.406788475414245 1871 4617066
SGTC_3088 9117578 49.47 µM 0.23476676027916 0.400768463535463 no 1326 0.407194884104105 2020 678341
SGTC_1202 1988-0068 29.6 µM 0.233098350598194 0.401416779123919 no 1327 0.407842517831965 1812 2850480
SGTC_3007 9078383 71.4286 µM 0.233008801491639 0.401451584074131 no 1328 0.407877285630649 1875 6496995
SGTC_1485 3909-9022 254 µM 0.232159866497639 0.4017815774841 no 1329 0.408206924037812 1982 714516
SGTC_1905 st060207 84.5 µM 0.23179256184033 0.401924375881926 no 1330 0.408349567267011 1874 1948547
SGTC_3208 9114115 49.47 µM 0.228798398171006 0.403088914821084 no 1331 0.40951280592252 1769 650895
SGTC_510 ag-490 170 µM 0.228763814757673 0.403102370610093 no 1332 0.409526246324624 2043 5328779
SGTC_1724 st037281 8.293 µM 0.22773796003668 0.403501564492824 no 1333 0.409924979958492 1848 574124 YDL195W SEC31
SGTC_299 1273-0059 1.44 µM 0.227166131715149 0.403724125415938 no 1334 0.410147281120115 2002 2848077
SGTC_59 0330-0160 1.33 µM 0.227154694131463 0.403728577348593 no 1335 0.410151727833631 1945 4293482
SGTC_3196 9111891 49.47 µM 0.226079150333723 0.404147274623331 no 1336 0.410569930213353 1981 18891510
SGTC_2858 9025781 8.96 µM 0.224708444828723 0.404681034195386 no 1337 0.411103047294199 2013 4894980 YPL153C RAD53
SGTC_297 0986-0032 24 µM 0.224336861615442 0.404825761164556 no 1338 0.411247597816564 1902 2847425
SGTC_491 tetrandrine 80.3 µM 0.224116491277957 0.404911598779973 no 1339 0.411333330330571 1991 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2122 5258151 111.688 µM 0.223283044425052 0.405236280413056 no 1340 0.411657611382053 1904 2173356
SGTC_2996 9066192 71.4286 µM 0.222911970342076 0.405380858847772 no 1341 0.411802009896651 1821 6472854
SGTC_1043 0916-0009 19.3 µM 0.222565505427462 0.405515860677978 no 1342 0.411936842865735 2079 3101130
SGTC_1307 1187-1599 12.2 µM 0.222383969716308 0.405586601487335 no 1343 0.412007494861056 1878 1538471
SGTC_3179 9107801 49.47 µM 0.222269072255401 0.405631376306779 no 1344 0.412052213348776 1895 4818259
SGTC_478 N-arachidonylglycine 10 µM 0.222042960669866 0.405719494178053 no 1345 0.412140220091699 2003 5283389
SGTC_2033 5192550 145 µM 0.218986993858871 0.406910900875675 no 1346 0.413330089642531 1882 182073
SGTC_1711 st032263 62.8 µM 0.218331168157296 0.407166695407729 no 1347 0.413585545750905 1956 3958979
SGTC_14 0354-0009 295 µM 0.217720297454878 0.407404991569977 no 1348 0.413823523972205 1958 1713507
SGTC_352 k048-0007 5.11 µM 0.217156305977542 0.407625030921062 no 1349 0.414043267456792 2011 6811911
SGTC_2200 6600604 21.907 µM 0.216948307102448 0.407706188332939 no 1350 0.414124315190382 1928 2904777
SGTC_2095 5432005 200 µM 0.216402817885912 0.407919047199204 no 1351 0.414336884977056 1923 783734
SGTC_783 0848-0141 92.7 µM 0.216248582595093 0.407979237278997 no 1352 0.414396992941969 1892 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_126 0417-1624 672.48 µM 0.216201759424932 0.407997510377333 no 1353 0.414415241078625 2065 41912 YDL195W SEC31
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.216055594833529 0.408054553508156 no 1354 0.414472206189386 2038 1241132 A phosphatase inhibitor.
SGTC_1470 k295-0292 231 µM 0.216006363649949 0.408073767224396 no 1355 0.414491393593155 1999 5045612
SGTC_1803 st050068 52.4 µM 0.21522940674983 0.408377023574953 no 1356 0.414794232434065 1978 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2502 avocadyne acetate 18.59 µM 0.213217561703338 0.409162527384175 no 1357 0.415578635473274 2035 3952079
SGTC_256 clotrimazole 625 nM 0.209979732445838 0.410427468833639 no 1358 0.416841745782779 1999 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2864 9034755 47.6 µM 0.208519962672095 0.410998071260942 no 1359 0.417411498618698 2081 4930451
SGTC_504 lovastatin 124 µM 0.20665233904191 0.41172837225367 no 1360 0.418140690886028 1872 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2789 5281112 71.43 µM 0.206598627836042 0.411749379602111 no 1361 0.418161665987217 1854 765948
SGTC_2882 9058044 58.44 µM 0.206418705178716 0.411819752196802 no 1362 0.418231930412403 1846 18076804
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.205584944897015 0.412145895276973 no 1363 0.418557569277687 1956 364106
SGTC_992 3909-8734 162 µM 0.204538690089475 0.412555245946695 no 1364 0.418966280343328 1898 4288319
SGTC_3314 9135860 59.4275 µM 0.204394068737797 0.412611837024656 no 1365 0.419022782407693 2068 25252478
SGTC_3272 9137413 49.47 µM 0.204316912187388 0.412642029522424 no 1366 0.419052927356188 2026 17614870
SGTC_2288 7946289 167.31 µM 0.201833853492878 0.413613962082655 no 1367 0.42002330744483 2032 1246052
SGTC_2773 thioridazine 9.09 µM 0.201485610513077 0.413750315749681 no 1368 0.420159439933394 2071 5452 An antipsychotic.
SGTC_445 e6 berbamine 66 µM 0.200575905757205 0.414106557398608 no 1369 0.420515099803686 1948 6610268 A calcium/calmodulin antagonist.
SGTC_892 0929-0076 29 µM 0.19951759921463 0.414521080644619 no 1370 0.420928938956535 1905 5751038
SGTC_1774 st048371 48.465 µM 0.198871612929607 0.414774150883981 no 1371 0.421181587780643 1883 4242727
SGTC_2131 toluylene red 5.2905 µM 0.196859267509727 0.415562729412362 no 1372 0.421968834847999 1909 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1952 st077036 64.1 µM 0.196118072050616 0.415853267839823 no 1373 0.422258875738307 2094 2937007
SGTC_789 1309-1135 70.6 µM 0.195376137221763 0.416144142158977 no 1374 0.422549248182071 2035 3092424
SGTC_1109 tnp00067 928.257 nM 0.193574815321606 0.416850538271965 no 1375 0.423254409816059 1931 676295
SGTC_2232 chlorophetanol 41.5365 µM 0.192312482465187 0.417345727700219 no 1376 0.423748720650327 2047 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2748 diazoxide 86.69 µM 0.190386255769698 0.418101602645208 no 1377 0.424503233505077 2038 3019 A potassium channel activatior.
SGTC_1839 st053978 48 µM 0.190297745168741 0.418136342581903 no 1378 0.424537910231636 2077 3788398
SGTC_2948 9070189 9.45 µM 0.188963844041442 0.418659968821949 no 1379 0.4250605772486 2093 6473636 YDL196W YDL196W
SGTC_1146 3579-1023 7 µM 0.188691462998839 0.418766910438359 no 1380 0.425167321468055 2081 X1146
SGTC_702 1488-0190 94 µM 0.188549490301665 0.418822653811657 no 1381 0.425222961747508 2106 949357
SGTC_506 n9-isopropylolomoucine 153 µM 0.187716165988792 0.419149878478124 no 1382 0.425549578461826 2115 6610355
SGTC_1556 plumbagin 1.48 µM 0.185071784988123 0.420188627060279 no 1383 0.426586365806306 2066 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.184990862304417 0.420220423390441 no 1384 0.426618101351362 2044 616764
SGTC_541 4513-1321 94 µM 0.183633901321118 0.420753681083625 no 1385 0.427150332972611 1914 747515
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.183092418489822 0.420966513328323 no 1386 0.427362752196006 2043 2333 A French combination drug.
SGTC_359 0081-0058 15.9 µM 0.182767845383129 0.421094099314427 no 1387 0.427490089632986 2061 3494159
SGTC_2841 9004761 38.96 µM 0.181831788003142 0.421462099159534 no 1388 0.427857368567134 1843 2991039
SGTC_2557 derrustone 83.84 µM 0.181401765841233 0.421631180285756 no 1389 0.428026116466115 1893 629853 An antioxidant.
SGTC_978 1416-0512 87.4 µM 0.180726573945672 0.421896689249803 no 1390 0.428291099624792 1985 6814003
SGTC_2285 7945142 200 µM 0.179972033299498 0.422193442910145 no 1391 0.428587261937155 1974 2970608
SGTC_1260 0700-1617 7.75 µM 0.179862049491846 0.422236702188658 no 1392 0.428630434688797 1990 2853078
SGTC_1911 st060208 74.3 µM 0.179428742784771 0.422407141268495 no 1393 0.428800532057936 2058 688783
SGTC_1716 st033144 30.6155 µM 0.175530576115935 0.423941115724969 no 1394 0.43033137372987 2105 674617
SGTC_818 4072-2707 53.5 µM 0.175092367276405 0.424113628590035 no 1395 0.430503527829245 2030 882871
SGTC_2892 9047358 58.44 µM 0.174485471225054 0.424352573787531 no 1396 0.430741973954604 1983 6466771
SGTC_1080 nisoldipine 24.4 µM 0.173845952375448 0.424604393217609 no 1397 0.430993264720569 1991 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_943 3253-1379 105 µM 0.173470473611057 0.424752257542395 no 1398 0.431140817330597 2036 668464
SGTC_2257 7960413 200 µM 0.172097763957958 0.425292923448209 no 1399 0.431680335320259 2044 2974689 YIL048W NEO1
SGTC_2102 5377816 72.7585 µM 0.171076433498928 0.425695283694585 no 1400 0.432081833012814 2107 1379702
SGTC_1882 5615643 20 µM 0.170767889281427 0.42581685207693 no 1401 0.432203139395555 2122 2253075
SGTC_2332 7982454 138.89 µM 0.169754288248061 0.42621626689579 no 1402 0.432601688874924 2095 2981748
SGTC_341 1486-1430 230 µM 0.16960983792774 0.426273194476279 no 1403 0.43265849255474 1992 2054753 YPL210C SRP72
SGTC_1865 st057639 52.2 µM 0.169459978532902 0.42633225538574 no 1404 0.432717424771211 2111 688818
SGTC_1403 3909-7815 62.9 µM 0.168537160670846 0.426695982408009 no 1405 0.433080355888434 2021 6615483
SGTC_3308 9128332 17.569 µM 0.168390858842926 0.426753652747275 no 1406 0.433137899504867 2104 17332805 YDL196W YDL196W
SGTC_933 2914-0560 114 µM 0.167802907941239 0.426985431371611 no 1407 0.433369167367118 2159 463887
SGTC_2806 7952793 58.44 µM 0.167112800873369 0.427257513568546 no 1408 0.433640647004842 2030 2972490
SGTC_1168 k815-0004 80.5 µM 0.165299213653902 0.42797270464562 no 1409 0.43435423885983 2006 642433
SGTC_483 fpl-64176 144 µM 0.164579626647834 0.42825654067364 no 1410 0.434637434051866 2110 3423
SGTC_287 k060-0039 29.6 µM 0.163803049398532 0.428562897744429 no 1411 0.434943095516933 2125 5861974
SGTC_833 3852-0053 558 µM 0.163197205398927 0.428801931036125 no 1412 0.435181583239815 2058 3123681
SGTC_66 0109-0187 42.4 µM 0.16202043378404 0.429266296057002 no 1413 0.435644881318281 2068 759417
SGTC_363 0455-0021 3.06 µM 0.161879066522066 0.429322087492705 no 1414 0.435700543937034 2035 4597466
SGTC_2309 7664088 163.95 µM 0.161213471525433 0.429584787494581 no 1415 0.43596263557942 2155 704922
SGTC_1901 st060216 58.6 µM 0.159883780900991 0.430109688983026 no 1416 0.436486312560171 2083 688792
SGTC_2119 5528445 120.635 µM 0.159622070130856 0.430213015092822 no 1417 0.43658939622399 2089 791935
SGTC_3151 9099821 49.47 µM 0.159219184066926 0.430372088002753 no 1418 0.43674809498085 2005 17174189
SGTC_3233 9132340 49.47 µM 0.159066050972476 0.430432553041802 no 1419 0.436808417514187 1993 17682950
SGTC_2086 5274770 176.623 µM 0.158133810348595 0.430800686051216 no 1420 0.437175679490011 2013 689278
SGTC_2403 6032726 181.2 µM 0.157836854582801 0.430917963720249 no 1421 0.437292678441318 2020 2881040
SGTC_3084 9116877 49.47 µM 0.157728725087508 0.430960669153437 no 1422 0.437335282234932 2130 27241325
SGTC_1581 himbacine 57.9 µM 0.156959613630532 0.431264450774026 no 1423 0.437638338579986 1975 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1240 0356-0016 42.1 µM 0.155961506173125 0.43165874123525 no 1424 0.43803168174181 2038 4305613
SGTC_1089 terbinafine 2.25 µM 0.155802981380288 0.43172137084312 no 1425 0.43809416026268 2123 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3105 9121040 49.47 µM 0.15351743310803 0.432624529947303 no 1426 0.4389951218138 2153 41448907
SGTC_1097 itavastatin 7.23 µM 0.152557617828048 0.433003916588045 no 1427 0.439373574868931 2067 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1332 1480-0653 17.5 µM 0.151939025874755 0.433248460472356 no 1428 0.439617513706386 2168 5749438
SGTC_554 4483-2211 187 µM 0.150829548882213 0.433687126681854 no 1429 0.440055088138042 2032 747107
SGTC_1120 ficusin 1.78878 µM 0.150117383860811 0.433968746339333 no 1430 0.440336002530653 2076 6199 A DNA cross-linker.
SGTC_828 2074-0507 139 µM 0.149173399091399 0.434342088802794 no 1431 0.440708404781974 2139 X828
SGTC_95 0471-0001 561.058 µM 0.149068112398383 0.434383732934542 no 1432 0.440749943668178 1943 4015405
SGTC_2732 terfenadine 20 µM 0.148670927578287 0.434540838321724 no 1433 0.440906651340111 2166 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2936 9038235 15.59 µM 0.148159949780689 0.434742969416191 no 1434 0.441108269180298 2121 4749415
SGTC_97 0535-0701 19.132 µM 0.146847330508192 0.435262289554456 no 1435 0.441626262631265 2117 2832013 YGL099W LSG1
SGTC_1914 st062367 72.6 µM 0.146518213539131 0.435392517797535 no 1436 0.441756156375112 2033 978205
SGTC_2012 4023501 200 µM 0.143999340132192 0.436389441453663 no 1437 0.442750495352143 2025 3477460
SGTC_788 1182-0090 188 µM 0.143730719765166 0.436495780404874 no 1438 0.442856556097381 2143 5715185
SGTC_1570 verbenone 133 µM 0.142377964313021 0.437031366346494 no 1439 0.443390733493706 2169 29025 A natural terpanoid with antifungal properties.
SGTC_1281 0884-0031 11.8 µM 0.140664270131663 0.437710021567733 no 1440 0.444067586343409 2059 1548255
SGTC_1223 0764-0573 147 µM 0.140385039455584 0.437820619599914 no 1441 0.444177888790358 2113 1609797
SGTC_3323 9138564 53.9225 µM 0.140284750108441 0.437860343514906 no 1442 0.44421750641177 2148 43912313 YNL103W MET4
SGTC_1740 st038286 13.222 µM 0.13879543556454 0.438450324165968 no 1443 0.44480590048316 2114 716786
SGTC_47 0149-0135 24.25 µM 0.137805334999322 0.438842620778488 no 1444 0.445197133935822 2139 5239155
SGTC_1163 k060-0048 49.9 µM 0.135610815910649 0.439712344477309 no 1445 0.446064477293883 2152 6809982
SGTC_233 rapamycin 362 pM 0.134940656779916 0.439977997671814 no 1446 0.446329397025023 2169 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3078 9116413 49.47 µM 0.134391219229404 0.440195816617303 no 1447 0.446546612344354 2143 17177322
SGTC_496 calpeptin 138 µM 0.133025842101537 0.440737184775131 no 1448 0.44708647154096 2056 73364 A calpain inhibitor.
SGTC_953 1188-0045 9.7 µM 0.132059249034934 0.441120503215997 no 1449 0.447468714051593 2106 6144426
SGTC_474 dl-dihydrosphingosine 5 µM 0.131903619340831 0.4411822259064 no 1450 0.447530262912521 2147 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2539 epi(13)torulosol 80 µM 0.131876770832053 0.44119287416153 no 1451 0.447540881162697 2054 6708597
SGTC_869 0564-0080 44.1 µM 0.13187066169986 0.441195297080366 no 1452 0.447543297253493 1999 6843321
SGTC_1752 st044819 83.042 µM 0.130942413351348 0.441563471519901 no 1453 0.447910431254355 2068 441209 YML126C ERG13
SGTC_187 1488-2104 32.728 µM 0.129588868272848 0.442100423332063 no 1454 0.448445855404499 2153 2852859
SGTC_2580 diallyl disulphide 81.36 µM 0.129084845022894 0.442300396773522 no 1455 0.448645256797409 2073 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3169 9102970 49.47 µM 0.128329843357071 0.442599974499009 no 1456 0.448943974386466 2190 17027839
SGTC_516 3992-2719 87.3 µM 0.127692461585265 0.442852907289831 no 1457 0.449196178018898 2127 5350887 YDR037W KRS1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.126815009512671 0.443201145479931 no 1458 0.449543407890343 2217 688664
SGTC_280 3448-3607 3.04 µM 0.126319008445642 0.443398014991819 no 1459 0.4497397051087 2179 626179
SGTC_2634 4'-methoxyflavone 100 µM 0.125796970390273 0.44360523402621 no 1460 0.449946320000721 2059 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_313 3474-0040 5.03 µM 0.123630482764311 0.444465368983626 no 1461 0.450803927939374 2131 1043375 YIL048W NEO1
SGTC_153 4077-0274 519.67 µM 0.122968615500655 0.444728194669059 no 1462 0.4510659752565 2203 3121976
SGTC_3232 9132874 49.47 µM 0.118540503624948 0.446487205442871 no 1463 0.45281970203259 2059 3784940
SGTC_2351 9026858 72.31 µM 0.118396248858747 0.446544526708865 no 1464 0.452876848926212 2143 1409300
SGTC_1953 st076800 12.1 µM 0.117032341217008 0.447086545906359 no 1465 0.453417212494441 1974 297591
SGTC_1937 st074714 47.2 µM 0.116727239341963 0.44720780747105 no 1466 0.453538101976603 2180 17250970
SGTC_60 0986-0278 202 µM 0.114079275833375 0.448260436449842 no 1467 0.454587475225183 1932 3110598
SGTC_2438 5259590 200 µM 0.113676388409073 0.448420625982867 no 1468 0.454747165244777 2187 1201127
SGTC_2765 myclobutanil 7.74 µM 0.113664000620466 0.448425551546933 no 1469 0.454752075432667 2100 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1671 st016596 74.5 µM 0.113096027027201 0.448651394595978 no 1470 0.454977212378831 2188 2829167
SGTC_3285 9112818 20.8695 µM 0.111002881523517 0.449483834077142 no 1471 0.455807030865125 2204 17017947 YPR165W RHO1
SGTC_2493 resveratrol 26.09 µM 0.110649555783349 0.449624373003275 no 1472 0.455947124447439 2179 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2737 bleomycin 30.5 nM 0.110380215924652 0.449731509931686 no 1473 0.456053921325153 2173 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3048 9093155 49.47 µM 0.109905221429382 0.449920460260804 no 1474 0.456242270765602 2233 25236002
SGTC_1238 0333-0287 48.8 µM 0.109773494927579 0.449972862387918 no 1475 0.456294505983557 2148 7226
SGTC_11 0438-0307 1.3 µM 0.109747624088268 0.449983154170475 no 1476 0.456304764971723 2223 4011476
SGTC_2263 7948595 193.29 µM 0.10966616779419 0.450015558845852 no 1477 0.456337066362016 2167 2971371
SGTC_1539 benzyladenosine 56 µM 0.108847686578474 0.450341182817923 no 1478 0.456661650032765 2182 92208 A nucleotide analog.
SGTC_2908 7930301 100 µM 0.108371428822164 0.450530672257972 no 1479 0.456850532064972 2215 2223178
SGTC_1176 0848-0131 83.3 µM 0.106483292428004 0.451282018683176 no 1480 0.457599455374525 2231 6769040
SGTC_2677 mitomycin C 100 µM 0.106024438076239 0.451464637140346 no 1481 0.457781481342753 2200 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1211 1056-0033 32.3 µM 0.105572045299046 0.451644694025618 no 1482 0.45796095269595 2226 6741922
SGTC_1778 st046819 58.9 µM 0.105079496640938 0.451840744666869 no 1483 0.458156364266336 2196 671715
SGTC_2513 baicalein 25.65 µM 0.10277532115672 0.452758037865967 no 1484 0.459070646194074 2115 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_378 3970-0959 8.33 µM 0.10210736481219 0.453023998923061 no 1485 0.459335727648228 2147 6615653
SGTC_2250 alverine citrate 130 µM 0.101585459520187 0.453231821312586 no 1486 0.45954286067913 2162 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_983 1491-0821 12.2 µM 0.101402937248234 0.453304504603304 no 1487 0.459615302453927 2222 46495113
SGTC_2205 7238770 200 µM 0.100144705569031 0.453805595032648 no 1488 0.460114721894512 2240 279867
SGTC_704 1310-0270 142 µM 0.0987284493514914 0.454369706634717 no 1489 0.460676939947933 2139 5718033
SGTC_1627 st003713 25.6 µM 0.0986406387282606 0.4544046856868 no 1490 0.460711801153887 2131 16195070 YER133W GLC7
SGTC_2794 7785382 27.27 µM 0.0980951944922202 0.454621969384111 no 1491 0.460928351681834 2283 2205081
SGTC_22 0964-0034 14.468 µM 0.0971938564547955 0.45498105701187 no 1492 0.461286223393225 2153 138402
SGTC_1948 st076329 66.6 µM 0.097069004538187 0.455030800168564 no 1493 0.461335797694334 2244 24208413
SGTC_3158 9100007 49.47 µM 0.0960303121736662 0.455444660380559 no 1494 0.461748249087139 2151 19297233
SGTC_2649 anisomycin 9.56 µM 0.0952432079429366 0.45575830916869 no 1495 0.462060825489391 2167 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0947189602222187 0.455967229039111 no 1496 0.46226902880358 2256 4000243
SGTC_1074 carmofur 3.8 µM 0.0937859356938254 0.456339082125623 no 1497 0.462639602064026 2235 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1022 4477-0945 21.3 µM 0.0932321831778132 0.456559796016635 no 1498 0.462859553625495 2197 4648966
SGTC_2857 9024691 58.44 µM 0.0930907651321633 0.456616164371532 no 1499 0.462915726967479 2168 16478292
SGTC_986 1493-0483 84 µM 0.0925341922530148 0.456838019333758 no 1500 0.463136813129265 2243 40079
SGTC_1464 k208-0027 110 µM 0.0920983600616535 0.457011755366395 no 1501 0.463309945698741 2222 X1464
SGTC_1761 st044296 37 µM 0.0915509351576592 0.45722998730311 no 1502 0.463527417863037 2235 1826700
SGTC_261 5-fluorouridine 15.376 µM 0.0915079221745666 0.457247135054676 no 1503 0.463544505832079 2228 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1721 st082152 9.2685 µM 0.0910040550404881 0.457448014938311 no 1504 0.463744684486321 2245 5296051
SGTC_63 0099-0242 26.702 µM 0.0906755639095841 0.45757898242373 no 1505 0.463875193900784 2267 3898502 YLR359W ADE13
SGTC_2331 7980721 200 µM 0.0884930336824031 0.458449260720694 no 1506 0.464742410467363 2205 2981221
SGTC_3044 9093193 49.47 µM 0.0882249595076998 0.458556168427103 no 1507 0.464848939922523 2140 25236277
SGTC_2388 9080168 200 µM 0.0879209393068502 0.458677414999256 no 1508 0.464969756945001 2226 15943073
SGTC_2974 9094440 9.66 µM 0.0876225123626287 0.458796434658755 no 1509 0.465088354359374 2180 25236134
SGTC_327 1273-0057 3.96 µM 0.0860915460941238 0.459407077738698 no 1510 0.465696821956862 2249 3108138
SGTC_1126 isoteolin 1.0172 µM 0.0854065046165564 0.459680345323926 no 1511 0.465969111061718 2247 133323
SGTC_2363 9053361 176 µM 0.0852127788907118 0.459757627260518 no 1512 0.466046115724234 2259 6469797 YMR079W SEC14
SGTC_3069 9117009 49.47 µM 0.0851817566163756 0.459770002946832 no 1513 0.466058446986099 2265 41904981
SGTC_1919 st067113 52.3 µM 0.0850246084823909 0.459832694500632 no 1514 0.466120913402766 2178 1268243
SGTC_1999 st074831 12.5 µM 0.0846753078306857 0.45997204558164 no 1515 0.466259763473281 2109 17112523
SGTC_1888 azatryptophan 97.5 µM 0.0844319505169557 0.460069134207329 no 1516 0.466356502566739 2145 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_531 3788-1495 174 µM 0.0844074223483145 0.460078919975892 no 1517 0.466366253083869 2156 2896655
SGTC_285 1486-1325 46 µM 0.0837026808691683 0.460360094240577 no 1518 0.466646412801237 2251 22310230
SGTC_628 1636-0253 16 µM 0.0828006257110513 0.460720020645072 no 1519 0.467005035796183 2240 4456143
SGTC_2060 5238662 140 µM 0.0817727632446354 0.461130184270357 no 1520 0.467413707650797 2173 790130
SGTC_2486 5283202 22.39 µM 0.0816193655557328 0.461191400444857 no 1521 0.467474700593576 2143 1377751
SGTC_1296 1068-0102 11.9 µM 0.0813126760835245 0.461313793286023 no 1522 0.467596646657883 2237 767053
SGTC_3124 9127567 49.47 µM 0.0811456349782051 0.461380457160349 no 1523 0.467663066929117 2259 17592030
SGTC_3343 9148379 18.9835 µM 0.0808834803084476 0.461485081775229 no 1524 0.467767308860079 2273 1955036
SGTC_798 1287-0182 476 µM 0.0804248468584362 0.461668126493258 no 1525 0.467949682986753 2260 1649755
SGTC_532 1548-0774 215 µM 0.0788596761102992 0.462292861064887 no 1526 0.468572118557221 2267 5932993
SGTC_469 w7 172 µM 0.0785321010880597 0.46242362376209 no 1527 0.468702398044555 2266 45115570 A P450 inhibitor.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.077628573970894 0.462784318308461 no 1528 0.469061756109382 2175 4213774
SGTC_2663 amphotericin b 100 µM 0.0775297079552967 0.462823788198232 no 1529 0.469101079430695 2237 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1351 1496-0003 46.5 µM 0.0771188799189926 0.462987805372276 no 1530 0.469264486861962 2249 3891978
SGTC_428 3448-4153 16.5 µM 0.0754972073998567 0.463635295935164 no 1531 0.469909559684744 2229 3834874
SGTC_639 0833-0042 114 µM 0.0743566042539137 0.464090766145329 no 1532 0.47036331897926 2203 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_212 3807-4682 38.772 µM 0.0740341603897123 0.46421953427784 no 1533 0.470491601887 2239 3125501 YBL034C STU1
SGTC_442 cape 100 µM 0.0737896605252684 0.464317177930833 no 1534 0.470588877151071 2268 5281787
SGTC_3245 9134821 49.47 µM 0.0733270669548296 0.464501925528015 no 1535 0.470772926678545 2266 17014901
SGTC_3006 9075424 71.4286 µM 0.0729283120616248 0.464661183794983 no 1536 0.470931582078777 2207 7465181
SGTC_1232 0279-0259 161 µM 0.0709323999321808 0.465458413468425 no 1537 0.471725778447299 2208 1560000
SGTC_937 3122-0005 46.7 µM 0.0707097180423719 0.46554736822999 no 1538 0.471814393160185 2290 759535
SGTC_1395 3486-0190 4.35 µM 0.0702834550618829 0.46571765235256 no 1539 0.471984025443639 2281 6748079
SGTC_536 3852-0578 10.6 µM 0.0699591998472597 0.46584719047757 no 1540 0.472113066919028 2268 2869208
SGTC_193 1273-0060 1.558 µM 0.0697084608881485 0.465947361755819 no 1541 0.472212853675783 2281 2847393 YHR072W ERG7
SGTC_2727 riluzole 51.77 µM 0.0689156423032709 0.466264110310805 no 1542 0.472528383682306 2305 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_972 1319-0219 195 µM 0.0685478303977249 0.466411066568869 no 1543 0.472674773217296 2194 23903702
SGTC_1180 1193-0155 285 µM 0.0675522293452448 0.466808873797248 no 1544 0.473071041970206 2215 2921347
SGTC_819 1013-0258 27.7 µM 0.0668622331052112 0.467084591548308 no 1545 0.473345689671297 2241 5753198
SGTC_1337 1486-1011 40.3 µM 0.0666877726886961 0.467154307237479 no 1546 0.473415134311512 2306 X1337
SGTC_295 k015-0027 31 µM 0.0661497490719573 0.46736931184048 no 1547 0.473629301761445 2226 3887424
SGTC_64 000l-0018 272.079 µM 0.0661084862631297 0.467385801647745 no 1548 0.473645727286296 2231 6811119
SGTC_1342 1486-1464 234 µM 0.06578829152383 0.467513762591128 no 1549 0.473773189025966 2295 3253938
SGTC_2237 6667747 47.222 µM 0.0648281175365993 0.467897501554047 no 1550 0.474155426988219 2134 729940 YDL015C TSC13
SGTC_2183 6420625 130.508 µM 0.064239109797868 0.468132916613526 no 1551 0.474389918286835 2287 2897619
SGTC_2928 9011484 9.79 µM 0.0637597765832167 0.468324505104879 no 1552 0.474580753346865 2219 2994751
SGTC_691 1548-0686 185 µM 0.0636913933915158 0.468351838323727 no 1553 0.474607978956215 2243 46495133
SGTC_1978 st071761 42 µM 0.0633908721699622 0.46847196043165 no 1554 0.474727627793606 2135 5147680
SGTC_2956 9076196 2.52 µM 0.063226418806287 0.468537695723123 no 1555 0.474793103848384 2312 16423868
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0629936079884153 0.468630756319543 no 1556 0.474885797149974 2306 16623 A steroid.
SGTC_901 1112-0062 60.1 µM 0.0620965181748344 0.468989362653533 no 1557 0.47524298487165 2307 1908457
SGTC_336 4111-0029 111 µM 0.0620506653754359 0.46900769271655 no 1558 0.475261242284 2193 3131175
SGTC_472 calcifediol 10 µM 0.061827671232559 0.469096837537754 no 1559 0.475350033590057 2204 5283731 A vitamin D metabolite.
SGTC_3325 9138760 55.175 µM 0.0611503652921007 0.469367608914414 no 1560 0.475619729233061 2266 43844959
SGTC_398 bronopol 33.3 µM 0.0610834501135843 0.469394360838692 no 1561 0.475646374716345 2190 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1730 st033808 45.1 µM 0.0598997767977344 0.46986760264209 no 1562 0.476117728833532 2098 1045166
SGTC_235 0330-0087 5 mM 0.0596694950296488 0.469959676052113 no 1563 0.476209433934188 2287 46494818 YHR062C RPP1
SGTC_1196 1588-0294 184 µM 0.0585689575209883 0.470399725346252 no 1564 0.476647718265812 2212 6144269
SGTC_1679 SEC14.276 6.7 µM 0.0559595226791895 0.471443249872389 no 1565 0.477687026413935 2301 1005053 YMR079W SEC14
SGTC_1390 3413-2614 145 µM 0.0559534646930966 0.471445672718716 no 1566 0.477689439420046 2254 3421432
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0559136220862589 0.471461607498298 no 1567 0.477705309475826 2285 390807
SGTC_371 0195-0006 7.36 µM 0.0553069086311416 0.471704264047536 no 1568 0.477946979150479 2256 3928593
SGTC_2881 9058953 51.95 µM 0.0548288061022932 0.471895489742889 no 1569 0.478137425481477 2296 17122249
SGTC_617 3770-0098 35 µM 0.0540015777207623 0.472226369872668 no 1570 0.478466953619143 2251 5962639
SGTC_618 k072-0232 33.2 µM 0.0537635690010633 0.472321573692481 no 1571 0.47856176762211 2265 5872756 YGL099W LSG1
SGTC_3135 9127742 49.47 µM 0.0533943718616085 0.472469256190227 no 1572 0.478708844710883 2199 3643468
SGTC_2035 5154463 94.595 µM 0.0525420083186632 0.472810224437635 no 1573 0.479048411872135 2307 2769623
SGTC_399 oxolinic acid 75 µM 0.0523984037398105 0.472867672083556 no 1574 0.479105623001395 2200 4628 A DNA gyrase inhibitor.
SGTC_2597 laccaic acid a 100 µM 0.052304199748939 0.472905357800727 no 1575 0.479143153491935 2265 5491415 A textile dye.
SGTC_920 mycophenolic acid 780.421 nM 0.051680895347341 0.47315471292213 no 1576 0.479391480099001 2270 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_946 3434-1334 87.4 µM 0.0502076950797476 0.473744113518449 no 1577 0.479978439751402 2288 4047976
SGTC_1610 st001799 48.1 µM 0.0472529175695929 0.474926438147582 no 1578 0.481155826235213 2289 621897
SGTC_2960 9079389 5.97 µM 0.0453492502305639 0.475688289199018 no 1579 0.481914465891967 2329 16457355
SGTC_1189 1431-2119 7.28 µM 0.0450178405168244 0.475820929118133 no 1580 0.482046544346906 2332 3107275
SGTC_2228 7354201 200 µM 0.0446644033258638 0.475962388033907 no 1581 0.482187403699107 2262 753451
SGTC_544 k015-0020 52.4 µM 0.043997709246567 0.476229232423619 no 1582 0.482453114928688 2274 3008304
SGTC_2796 7949634 45.45 µM 0.0426865464838381 0.476754056472835 no 1583 0.482975702072798 2312 2971588
SGTC_3302 9125395 16.351 µM 0.0424685332622142 0.476841325379228 no 1584 0.483062597964237 2254 17599668
SGTC_3176 9106582 49.47 µM 0.0422350948032107 0.476934770113006 no 1585 0.483155642951477 2321 17018027
SGTC_158 k038-0087 26.446 µM 0.041973522714562 0.477039478163161 no 1586 0.483259902661356 2238 X158
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0417297571208078 0.477137059649992 no 1587 0.483357065932061 2341 229346 A bile salt which induces apoptosis.
SGTC_408 cantharidin 100 µM 0.040140827293648 0.477773155404262 no 1588 0.483990426271392 2249 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_83 0170-0301 39.027 µM 0.0395963060076226 0.477991156541488 no 1589 0.484207486255013 2332 3089716
SGTC_555 4296-0685 37 µM 0.0394847056623464 0.478035836973193 no 1590 0.484251973560757 2340 2908540 YHR072W ERG7
SGTC_1515 3460-0031 42.1 µM 0.0394262281694764 0.478059249194053 no 1591 0.484275284553542 2303 2876596
SGTC_2408 sulbentine 18.36 µM 0.039302006670009 0.478108983129718 no 1592 0.484324803381369 2209 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2606 farnesol 9.78 µM 0.0389098086864969 0.478266007693283 no 1593 0.484481148145726 2327 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_569 4130-2812 160 µM 0.0386618625473301 0.478365279793654 no 1594 0.484579989969775 2359 743552
SGTC_1764 st044502 93.5 µM 0.0382911886678705 0.478513691843575 no 1595 0.484727758030097 2298 8407
SGTC_2807 7945238 51.95 µM 0.0361855035488787 0.479356831307072 no 1596 0.485567222456152 2319 17148797
SGTC_991 3996-0057 64.7 µM 0.0357314218789573 0.479538662835892 no 1597 0.485748257753323 2318 715343
SGTC_2953 9074162 66.49 µM 0.0353868584810278 0.479676641936945 no 1598 0.485885631781433 2345 16451992
SGTC_2808 7946468 45.46 µM 0.0346935078297287 0.479954298929875 no 1599 0.486162068906997 2322 2970879
SGTC_2124 5246320 200 µM 0.0336851791091208 0.480358108359007 no 1600 0.486564098811861 2316 579342
SGTC_542 3381-0244 89.3 µM 0.0330591685786527 0.480608819464343 no 1601 0.486813701845964 2352 1112843
SGTC_1835 st008666 49.2 µM 0.0328538548042786 0.480691047301623 no 1602 0.486895565721619 2304 690455
SGTC_161 4065-0411 162.148 µM 0.032156471976587 0.480970354119443 no 1603 0.48717363427115 2312 1906281 YLR208W SEC13
SGTC_2020 4017018 200 µM 0.0304679393062079 0.481646661973798 no 1604 0.487846931115972 2330 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2414 st077232 92.9 µM 0.0280524871902231 0.482614214160491 no 1605 0.488810144436602 2318 729801
SGTC_2636 apigenin dimethyl ether 100 µM 0.027474203018967 0.482845871549261 no 1606 0.489040757543586 2336 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2323 6148992 148.28 µM 0.0274538207559626 0.482854036675381 no 1607 0.489048885824023 2331 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3340 9146634 11.102 µM 0.0273337878206566 0.482902121965327 no 1608 0.489096754072901 2312 4907387
SGTC_638 3970-0837 4.09 µM 0.0273015166321909 0.482915049871702 no 1609 0.489109623611549 2338 4118451 YLR208W SEC13
SGTC_2624 nerol 100 µM 0.0268177999436462 0.483108829945493 no 1610 0.489302528010813 2348 637566 A natural product oil.
SGTC_3149 9097855 49.47 µM 0.0262736424279499 0.483326827777377 no 1611 0.48951953897374 2340 25236625 YMR079W SEC14
SGTC_2419 paclitaxel 166.5 µM 0.0260198571017792 0.483428499772898 no 1612 0.4896207500677 2341 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_49 0717-0965 32.132 µM 0.0254667490291053 0.483650090782715 no 1613 0.489841335155783 2342 5889349 YGL099W LSG1
SGTC_1818 st052136 56.3 µM 0.0244056130790677 0.484075226458247 no 1614 0.490264535535426 2326 674169
SGTC_1129 3453-1384 223 µM 0.0235676888506782 0.484410946950018 no 1615 0.490598722775411 2315 1084452
SGTC_252 miconazole 1.30953 nM 0.0232647670779415 0.484532317513669 no 1616 0.490719537950535 2362 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_699 0375-0592 111 µM 0.0226085305537538 0.484795254312372 no 1617 0.490981269585047 2368 762578
SGTC_1023 4482-3888 16 µM 0.0217014430172138 0.485158711407222 no 1618 0.491343056341773 2357 3303168
SGTC_3274 9138298 49.47 µM 0.0213719444255532 0.485290739882703 no 1619 0.491474476778874 2370 17015756
SGTC_2266 7929956 200 µM 0.0201286184698046 0.485788948919099 no 1620 0.491970385264819 2372 2967153
SGTC_3192 9110362 49.47 µM 0.0196910806562106 0.48596427856763 no 1621 0.492144903003517 2381 16649480
SGTC_1995 st072814 61.1 µM 0.01959793627443 0.486001603628408 no 1622 0.492182055066271 2353 5769371
SGTC_2628 lathosterol 100 µM 0.0186343341534094 0.486387747932846 no 1623 0.492566406446433 2359 6710616
SGTC_3264 9137442 49.47 µM 0.0180358048675582 0.48662760303898 no 1624 0.492805144948751 2364 17015726
SGTC_1465 k213-0056 144 µM 0.0168407798124512 0.487106512723458 no 1625 0.493281818458716 2342 24048857 YMR208W ERG12
SGTC_3211 9128781 49.47 µM 0.0162405448427133 0.487347065650559 no 1626 0.493521244807738 2306 17194361
SGTC_2980 9014342 25.29 µM 0.0159268599191732 0.48747278130033 no 1627 0.493646370800764 2325 2996599
SGTC_731 3966-0296 387 µM 0.0156513320015623 0.487583205776751 no 1628 0.493756276835786 2376 660956
SGTC_1926 methyl fluorone black 53.6 µM 0.0152243287741309 0.487754339524626 no 1629 0.493926606177566 2378 72721 Reacts with homocysteine.
SGTC_1379 2144-0755 36.5 µM 0.0146251238909295 0.48799449180289 no 1630 0.49416562771432 2380 5392327
SGTC_3103 9120822 49.47 µM 0.0144366465090435 0.488070031598487 no 1631 0.494240811372936 2386 17141819
SGTC_921 1561-0023 372 µM 0.0120173850380459 0.489039683761847 no 1632 0.495205872401426 2389 24050882
SGTC_602 3130-1533 38.1 µM 0.0113001844827768 0.489327154059139 no 1633 0.495491974575115 2382 720941
SGTC_2646 retinol 96.75 µM 0.0106122688325133 0.48960289151177 no 1634 0.495766396736783 2378 445354 A vitamin A analog and teratogen.
SGTC_707 0865-0008 204 µM 0.0099035625885167 0.489886967660191 no 1635 0.496049114741112 2377 723043
SGTC_853 0419-0306 21 µM 0.00973661528328162 0.489953887178328 no 1636 0.4961157138684 2382 762713
SGTC_919 tnp00227 403.569 nM 0.00956390711101333 0.490023116192416 no 1637 0.496184611252206 2385 1269246 A methoxyflavone. YNL221C POP1
SGTC_500 h-89 112 µM 0.0081024092655559 0.490608960486811 no 1638 0.496767641737759 2393 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_271 rotenone 740 µM 0.00801264156409761 0.490644944720317 no 1639 0.496803452706764 2353 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3106 9121286 49.47 µM 0.00775157221052449 0.490749597275482 no 1640 0.496907601074431 2372 15943471
SGTC_754 3474-0146 171 µM 0.00760356814545642 0.490808926635026 no 1641 0.496966644413421 2399 24762078
SGTC_2877 9040724 71.43 µM 0.00704870455255101 0.491031352741478 no 1642 0.497187997017319 2397 6463895
SGTC_3345 9148410 3.559 µM 0.00598709547041884 0.491456923742816 no 1643 0.497611508749428 2390 4903596
SGTC_1107 amlodipine 47 µM 0.0056719048004443 0.491583277239688 no 1644 0.497737249497001 2387 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_521 r062-0005 13.8 µM 0.0041324906910238 0.492200408789183 no 1645 0.498351379432367 2399 2832033
SGTC_2421 5690543 90.72 µM 0.00393410212749128 0.49227994163187 no 1646 0.498430524374432 2372 3397993
SGTC_2816 7982706 58.44 µM 0.00385232513681693 0.492312725650144 no 1647 0.498463148426322 2393 2981853
SGTC_1207 2099-0101 141 µM 0.00156526357187274 0.493229618306983 no 1648 0.499375550436197 2403 5837381
SGTC_78 0336-0123 156.75 µM 0.00107194459865864 0.493427396826407 no 1649 0.499572356059246 2403 6765896
SGTC_1375 2910-0797 186 µM 0 0.493857160006939 no 1650 0.5 2406 742508
SGTC_1943 st076331 65.2 µM -0.00132068054346928 0.49438665595616 no 1651 0.499473124845469 2407 24208415
SGTC_294 k038-0071 157 µM -0.00147279475813085 0.494447643242639 no 1652 0.499412440113043 2410 24152826
SGTC_2523 spermine 47.74 µM -0.00155911898757458 0.49448225335003 no 1653 0.499378001767677 2409 1103 A DNA binding polyamine.
SGTC_2933 9026794 32.47 µM -0.00218843137474618 0.494734565781443 no 1654 0.499126942893736 2410 17586027
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.00282940948223877 0.494991557555897 no 1655 0.498871230435038 2411 688788
SGTC_2719 novobiocin 32.65 µM -0.00324036806721009 0.495156327116655 no 1656 0.49870728243618 2406 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_599 1935-0052 86.5 µM -0.00330960464394671 0.495184086882469 no 1657 0.498679661186502 2412 9557311
SGTC_849 0386-0493 241 µM -0.00522428330810838 0.495951768370871 no 1658 0.49791582198423 2418 726119
SGTC_6 0844-0013 19.835 µM -0.0063830323605361 0.496416370867397 no 1659 0.497453555805896 2419 1584900
SGTC_139 0099-0334 718.624 µM -0.00678599986278179 0.496577942576378 no 1660 0.497292798517632 2419 97690
SGTC_2929 9013348 24.6 µM -0.00679355350188678 0.496580971248829 no 1661 0.497289785121084 2431 2995952
SGTC_311 1315-0136 58 µM -0.00680786941771772 0.496586711293244 no 1662 0.497284074029046 2422 6759207
SGTC_655 k060-0012 42 µM -0.00695866042590369 0.496647171811859 no 1663 0.497223918545513 2413 5994525
SGTC_3200 9114385 49.47 µM -0.00711553612097615 0.496710072102256 no 1664 0.497161335747639 2429 17018030 YLR208W SEC13
SGTC_2924 9010168 62.78 µM -0.00722180971709466 0.496752683211385 no 1665 0.497118939806252 2433 2993929
SGTC_2386 9075165 157.42 µM -0.00732139731250371 0.496792613557448 no 1666 0.49707921115422 2420 16452277
SGTC_667 1498-1044 59 µM -0.00862651698545696 0.497315913280626 no 1667 0.496558560325438 2431 6739982
SGTC_328 k915-0120 63.5 µM -0.00926341128710034 0.497571283634704 no 1668 0.496304486429392 2421 6624543
SGTC_1847 st056231 15 µM -0.0103392166049626 0.498002642792754 no 1669 0.495875322837768 2421 5393180
SGTC_815 1582-0027 36.9 µM -0.0109449177947044 0.49824550819885 no 1670 0.495633696710485 2436 3128206
SGTC_2109 5483026 200 µM -0.0114606813307732 0.498452312206095 no 1671 0.495427949742846 2434 759335
SGTC_345 1362-0200 395 µM -0.0118482499208709 0.498607714584567 no 1672 0.495273342746893 2442 1419823
SGTC_2054 5233173 129 µM -0.012327478770857 0.498799870030708 no 1673 0.495082172065577 2440 6889
SGTC_1523 st012844 44.7 µM -0.0132637288176225 0.499175277126561 no 1674 0.494708692926184 2465 4274103
SGTC_229 benomyl 22.8748 µM -0.0134875270814864 0.499265013377605 no 1675 0.494619418322936 2444 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1552 6-methylflavone 10.6 µM -0.0139239756547591 0.499440015994153 no 1676 0.494445316888257 2427 689013
SGTC_1233 0325-0408 14.2 µM -0.0143644731388329 0.499616642210062 no 1677 0.494269601396489 2436 12874
SGTC_682 0kpi-0099 17 µM -0.0153205489268045 0.5 no 1678 0.493888224366942 2453 1714895 YML126C ERG13
SGTC_840 0245-0196 390 µM -0.0153932589564696 0.499970845448766 no 1679 0.493859220682142 2486 3827528
SGTC_1127 asiatic acid 681.4 nM -0.0157429498248632 0.499830629855037 no 1680 0.49371973111516 2443 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_162 k030-0015 37.8 µM -0.0157807708281236 0.499815464763305 no 1681 0.493704644592009 2452 1809920 YMR134W ERG29
SGTC_1430 4049-0248 69.1 µM -0.0158493494458062 0.499787966788316 no 1682 0.493677289103128 2436 22774488
SGTC_971 1315-0384 26.7 µM -0.0170434861605211 0.499309153949964 no 1683 0.493200961931298 2442 6769120
SGTC_1989 st071868 50.2 µM -0.0171949305137375 0.499248429384728 no 1684 0.493140553228286 2433 16414057
SGTC_837 0091-0265 12.5 µM -0.0180140221961122 0.498919998947311 no 1685 0.492813833565801 2435 759367
SGTC_1409 3909-8004 61.9 µM -0.0195202737483011 0.49831604072297 no 1686 0.492213032005725 2454 2119279
SGTC_1164 k060-0068 93.7 µM -0.0197201556923966 0.498235894779051 no 1687 0.492133305994122 2436 5963676
SGTC_1336 1486-0901 104 µM -0.0197570013912787 0.498221120899422 no 1688 0.492118609550219 2503 5006114
SGTC_2755 lomerizine 42.69 µM -0.0197726960350818 0.498214827878577 no 1689 0.492112349516088 2456 3949 A calcium channel blocker.
SGTC_353 1988-1175 58.3 µM -0.0209552498059269 0.497740665239471 no 1690 0.491640676655005 2397 2788357
SGTC_877 0771-0151 33.1 µM -0.0213013764159028 0.497601881167077 no 1691 0.49150262293402 2490 6166523
SGTC_1396 3511-0007 98.6 µM -0.0217375119849191 0.497427007219555 no 1692 0.491328670299151 2469 X1396
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0218819612510124 0.497369088608099 no 1693 0.491271057083497 2458 641818
SGTC_2471 5466956 24.79 µM -0.0220290019942383 0.497310130970741 no 1694 0.491212410450943 2495 724419
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.0228971897519202 0.496962022579406 no 1695 0.490866141031131 2437 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2462 5162487 171.77 µM -0.023413859607614 0.496754859817353 no 1696 0.490660074834497 2434 2259986
SGTC_1125 tnp00248 1.32998 µM -0.0242233832676958 0.496430276845496 no 1697 0.490337213225319 2463 24207736
SGTC_1041 0206-0046 107 µM -0.0244632833719103 0.496334088021139 no 1698 0.490241535284377 2517 50494
SGTC_3164 9100705 49.47 µM -0.0253137521743849 0.495993091198947 no 1699 0.489902352398835 2481 17174235
SGTC_929 2805-0021 398 µM -0.0253476741139061 0.495979490202278 no 1700 0.489888823843888 2513 3098024
SGTC_3312 9133330 71.43 µM -0.0256805883152991 0.495846008552583 no 1701 0.489756053515663 2461 17617324
SGTC_424 splitomicin 100 mM -0.0262341465586061 0.495624060909555 no 1702 0.489535290116615 2499 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_662 k832-1615 104 µM -0.0266707924645433 0.49544898989628 no 1703 0.489361154539432 2477 5878478
SGTC_1151 3909-8316 15.3 µM -0.0272914630729829 0.495200136606608 no 1704 0.489113632907447 2523 800431
SGTC_373 0844-0104 25.9 µM -0.0273180319030033 0.495189484071726 no 1705 0.489103037428274 2458 5375804
SGTC_914 3820-6779 408 µM -0.0275955375260756 0.495078220879399 no 1706 0.488992370424944 2466 2893481
SGTC_2555 cholic acid 100 µM -0.0285886078577931 0.494680062143864 no 1707 0.488596348992347 2570 6708657 Influences liver metabolism.
SGTC_1524 corynanthine 62.1 µM -0.0287038565090616 0.494633855019874 no 1708 0.488550390293497 2593 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2435 5706476 10.6 µM -0.0287673085731972 0.494608414948989 no 1709 0.488525087031374 2471 5725375
SGTC_1425 4048-4433 7.33 µM -0.0288454025056668 0.49457710448976 no 1710 0.488493944983489 2459 23734946
SGTC_2369 9071472 200 µM -0.0293531734467878 0.494373523026472 no 1711 0.48829145943584 2507 17296037
SGTC_2366 9070441 60.58 µM -0.0302242647894797 0.49402427834202 no 1712 0.487944098432803 2469 6837235
SGTC_380 3970-0968 6 µM -0.0303235125361609 0.493984487452756 no 1713 0.487904522450448 2463 2891601
SGTC_1994 st072947 40.9 µM -0.0303754158561717 0.49396367814509 no 1714 0.487883825555652 2541 5286565 YDL195W SEC31
SGTC_253 dyclonine 31.25 µM -0.0313623904889519 0.493567979118861 no 1715 0.487490267214337 2459 3180 An oral anasthetic.
SGTC_1726 st035556 14.5795 µM -0.0318049941606416 0.493390531968406 no 1716 0.487313781944277 2648 5919439
SGTC_1453 4237-0541 195 µM -0.0328181957013869 0.492984327652185 no 1717 0.486909783978282 2462 739892
SGTC_1477 0139-0234 16 µM -0.0334805397078318 0.492718790120009 no 1718 0.486645692097355 2454 620880
SGTC_248 streptozotocin 5.23457 mM -0.0337884882062774 0.492595332882558 no 1719 0.48652290789296 2526 5300 DNA alkylating agent.
SGTC_3087 9117406 49.47 µM -0.0345645089153646 0.492284227627841 no 1720 0.486213501180806 2558 42546093
SGTC_1434 4073-0095 163 µM -0.0346269082697159 0.492259212044424 no 1721 0.486188622332832 2466 24133745
SGTC_443 clozapine 122 µM -0.036780694587004 0.49139578941066 no 1722 0.485329933559907 2464 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_134 0269-0018 6.916 µM -0.0374939921210438 0.491109847152099 no 1723 0.485045565186636 2508 4378915
SGTC_1644 st010134 20.9 µM -0.037620049141215 0.491059314672334 no 1724 0.484995311166479 2486 3818134
SGTC_1204 4049-0315 18.3 µM -0.0386653427263603 0.490640293419833 no 1725 0.484578602616563 2662 588402
SGTC_1299 1079-1439 3.74 µM -0.0396041255576713 0.490263977354548 no 1726 0.484204369150929 2485 323161
SGTC_2476 5806916 10.51 µM -0.039869362599837 0.490157657238383 no 1727 0.484098638388654 2501 2870194
SGTC_888 0916-0002 6.97 µM -0.039992332361753 0.490108365116689 no 1728 0.484049619646548 2612 2802138 YIL048W NEO1
SGTC_661 1304-0007 33.6 µM -0.0410275939591586 0.489693389156457 no 1729 0.48363694878966 2502 3117130
SGTC_1809 st050081 57.6 µM -0.0422875763261294 0.489188350849164 no 1730 0.483134724541745 2542 5036894
SGTC_671 0560-0003 407 µM -0.0432655204993357 0.488796373723013 no 1731 0.482744938063987 2551 3238678
SGTC_3028 9087778 49.47 µM -0.0448642279054354 0.488155607314782 no 1732 0.482107765057476 2495 17217395
SGTC_2154 5570129 200 µM -0.0455614744982023 0.487876158403627 no 1733 0.481829888080899 2484 673366
SGTC_151 3013-0144 2.285 µM -0.0459581200832721 0.487717189780288 no 1734 0.48167181497369 2629 906558 YHR107C CDC12
SGTC_464 bw-b 70c 158 µM -0.0477033579358067 0.487017752452077 no 1735 0.480976328952914 2594 5353454
SGTC_86 0417-1630 471.922 µM -0.0485968152653769 0.486659697719109 no 1736 0.480620304009148 2474 3634867
SGTC_226 1,3-diallylurea 8.28947 mM -0.0498018701999114 0.486176786736521 no 1737 0.480140138165186 2561 74537 YKL182W FAS1
SGTC_488 nitrendipine 139 µM -0.0507185216249703 0.485809463458413 no 1738 0.479774908760234 2488 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0512503195113972 0.485596365330653 no 1739 0.479563027663281 2516 4330530
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0512799013461814 0.485584511636146 no 1740 0.479551241716226 2520 6728940
SGTC_2061 5245884 80.95 µM -0.0517285356605408 0.48540474159226 no 1741 0.479372499751598 2512 573863
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.053240183149873 0.484799038828363 no 1742 0.47877026973757 2618 61125 An anti-inflammatory.
SGTC_2304 7443016 91.4 µM -0.0535257755169956 0.484684608581218 no 1743 0.478656497094666 2487 939854
SGTC_175 3793-3120 23.7 µM -0.0535648463224109 0.484668953912242 no 1744 0.47864093242719 2522 5322297
SGTC_3322 9139058 2.11 µM -0.0567401125411883 0.483396787383314 no 1745 0.477376110140796 2637 4908926 YPR165W RHO1
SGTC_660 4031-1742 102 µM -0.0572050113357402 0.483210540124586 no 1746 0.477190943115503 2501 6738706
SGTC_414 piperonyl butoxide 100 µM -0.0575087077991376 0.483088875547422 no 1747 0.477069984884797 2503 5794 A potent inhibitor of cytochrome P450.
SGTC_1854 st056233 32.9 µM -0.0584597120300677 0.482707901672842 no 1748 0.476691226362986 2500 5393174
SGTC_960 1222-0186 7.7 µM -0.0587131218585845 0.482606387924367 no 1749 0.476590303818767 2572 3126296
SGTC_456 gingerol 170 µM -0.0593228154843239 0.482362154653208 no 1750 0.476347494492647 2591 442793 A herb.
SGTC_751 0833-0568 350 µM -0.0594205877335426 0.48232298930649 no 1751 0.476308557695196 2559 6954252
SGTC_292 k038-0015 474 µM -0.0594545158442721 0.482309398514271 no 1752 0.476295046225237 2570 46368540
SGTC_3016 9080866 49.47 µM -0.0613608476979059 0.481545800920617 no 1753 0.475535916293379 2518 17066299
SGTC_1571 st070080 73.4 µM -0.0613675606876176 0.48154311209292 no 1754 0.475533243235484 2564 4315245
SGTC_2406 ethylparaben 405.7 µM -0.0614063536334745 0.481527573943557 no 1755 0.475517796221581 2537 8434 A possible steroid mimic.
SGTC_1669 st015249 58.4 µM -0.0615018731321066 0.481489314627028 no 1756 0.475479761344253 2536 722793
SGTC_1178 0988-0033 191 µM -0.0620249191384932 0.4812798171592 no 1757 0.475271493800043 2607 5392207
SGTC_3223 9129970 49.47 µM -0.0626436184794722 0.481032014001754 no 1758 0.475025147539915 2534 17248386
SGTC_2353 9059630 146.67 µM -0.0628121061977262 0.480964532104313 no 1759 0.474958062777419 2574 4779114
SGTC_2424 5537928 59.2 µM -0.0645684517595324 0.480261121796196 no 1760 0.474258802061398 2538 5382802
SGTC_2455 5377712 9.75 µM -0.0646251033334035 0.48023843404871 no 1761 0.474236248457658 2583 2243908
SGTC_627 1391-0720 175 µM -0.0656655490013519 0.479821769201473 no 1762 0.473822050552106 2574 997839
SGTC_3219 9131112 49.47 µM -0.0660007080873091 0.479687553497987 no 1763 0.473688630856703 2531 17612988 YMR079W SEC14
SGTC_2076 5212012 200 µM -0.0664716831166031 0.479498953689867 no 1764 0.47350115071722 2506 604802
SGTC_575 k072-0246 11.9 µM -0.0687652757509764 0.478580561330562 no 1765 0.472588229284964 2530 6796779
SGTC_3292 9120825 59.784 µM -0.0688331502359971 0.478553384974551 no 1766 0.472561215291943 2527 24824900
SGTC_335 4077-0256 27.6 µM -0.0707671963706266 0.477779052037955 no 1767 0.471791519924519 2629 3121989
SGTC_58 0957-0393 9 µM -0.0709321675870438 0.477713006448419 no 1768 0.471725870906706 2529 6997992
SGTC_3027 9089541 49.47 µM -0.071478262278373 0.477494383923844 no 1769 0.471508562244107 2612 9943819
SGTC_362 0310-0100 9.03 µM -0.0719026746749901 0.47732448013481 no 1770 0.471339680739343 2604 790235
SGTC_438 sphingosine 6.67 µM -0.0720006664582138 0.477285251951789 no 1771 0.47130068873628 2554 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1355 1499-0035 1.68 µM -0.0720110581145843 0.477281091964896 no 1772 0.4712965537986 2550 1548538
SGTC_560 2332-1943 155 µM -0.0728136832574172 0.476959792658629 no 1773 0.470977191098295 2520 21177716
SGTC_2284 7945075 39.21 µM -0.0729339330586264 0.47691165668044 no 1774 0.470929345581239 2600 1245402
SGTC_2278 7948257 134.34 µM -0.0729507483581965 0.476904925545264 no 1775 0.470922655069697 2534 1247028
SGTC_3148 9097893 49.47 µM -0.0737059836434652 0.476602612997016 no 1776 0.470622168741724 2565 17174100
SGTC_254 nsc-64875 3.808 µM -0.0740202496811451 0.47647681964543 no 1777 0.470497136271714 2663 56993
SGTC_2525 harmine 47.85 µM -0.0755637240733374 0.475859037177623 no 1778 0.469883098956355 2606 5280953 A monoamine oxidase inhibitor
SGTC_1503 4585-0012 61.3 µM -0.0759097514481202 0.475720546096945 no 1779 0.469745449356459 2699 2922052
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0759266398886755 0.475713786884743 no 1780 0.469738731231594 2548 803109
SGTC_2752 diclazuril 33.15 µM -0.0763637503272926 0.475538845862525 no 1781 0.469564854206567 2582 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1496 4469-0713 57.4 µM -0.078108928864894 0.474840435113481 no 1782 0.468870702344641 2531 746691
SGTC_1197 1601-0112 267 µM -0.0785692380298426 0.474656234741171 no 1783 0.468687628185225 2533 7350313
SGTC_688 0527-0193 473 µM -0.0789773915468646 0.474492909849479 no 1784 0.468525302906872 2590 4007154
SGTC_3073 9114972 49.47 µM -0.07987327424192 0.474134432493418 no 1785 0.468169022982776 2550 41905075
SGTC_1702 st027038 51 µM -0.0813260413873732 0.473553168747321 no 1786 0.46759133227375 2607 5521182
SGTC_552 k242-0005 476 µM -0.0818223710620694 0.47335459611921 no 1787 0.467393983092438 2639 4088318
SGTC_1769 st044406 64.4 µM -0.0818361021785662 0.473349102638914 no 1788 0.467388523478994 2557 670903
SGTC_935 2996-0153 430 µM -0.0822466787290971 0.473184843456185 no 1789 0.467225277447637 2557 23738523
SGTC_1067 clotrimazole 1.36 µM -0.0837365061882319 0.472588847324425 no 1790 0.466632965659296 2571 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2617 dihydrotanshinone i 20.83 µM -0.0840590220977571 0.47245983489164 no 1791 0.466504752458187 2583 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1322 1348-1070 12 µM -0.0849018207215408 0.472122713256992 no 1792 0.466169722144741 2542 6758089
SGTC_1562 morin hydrate 59.1 µM -0.0856172204462153 0.471836567173455 no 1793 0.4658853543948 2675 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2823 7987624 58.44 µM -0.0856231497611431 0.471834195622449 no 1794 0.465882997594866 2641 2239440
SGTC_756 0508-1999 28.3 µM -0.0868467824120778 0.471344800160909 no 1795 0.465396650543543 2566 6753853
SGTC_2868 9035608 32.47 µM -0.0871588160847813 0.47122000827414 no 1796 0.465272637366486 2531 6462614
SGTC_160 3453-0671 289.699 µM -0.0876648556939735 0.471017633444288 no 1797 0.465071526569105 2577 5322268
SGTC_3108 9121785 49.47 µM -0.0887252184268379 0.470593598625457 no 1798 0.464650145082467 2520 17140271
SGTC_3141 9094609 49.47 µM -0.0895598372549592 0.470259861316784 no 1799 0.464318500662679 2560 25236309 YDL196W YDL196W
SGTC_3155 9099265 49.47 µM -0.0902229943036239 0.46999470095739 no 1800 0.464055006015556 2636 25236499
SGTC_2450 5739737 12.93 µM -0.0904612181462244 0.46989945146887 no 1801 0.463960355496351 2623 2262825
SGTC_497 capsazepine 133 µM -0.0912799924223352 0.469572092571546 no 1802 0.463635057672964 2575 2733484 A calcium channel blocker.
SGTC_2878 9043973 25.97 µM -0.0917829239899831 0.469371022763672 no 1803 0.463435255735166 2742 6465167
SGTC_718 1130-0073 349 µM -0.0921008808465821 0.469243909050796 no 1804 0.463308944307145 2652 6740020
SGTC_2810 7959871 45.46 µM -0.0923019889995834 0.469163511068632 no 1805 0.463229054062496 2645 2974535
SGTC_3033 9090887 49.47 µM -0.0945158654763417 0.468278542754416 no 1806 0.462349690017269 2579 19325384
SGTC_732 3970-1727 52.7 µM -0.0948883420638205 0.468129665369354 no 1807 0.46220175821083 2640 1275699
SGTC_2680 butyl paraben 22.24 µM -0.0961165829292592 0.4676387741586 no 1808 0.461713990505767 2571 7184 An antifungal and steroid mimetic.
SGTC_2515 chrysin 20.77 µM -0.0970119525625095 0.467280952612176 no 1809 0.461358451225604 2671 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1990 st072050 59.8 µM -0.0970713788315192 0.467257204694197 no 1810 0.461334854940424 2556 17233948
SGTC_1148 3909-7663 27.7 µM -0.0999899900406768 0.466091014741526 no 1811 0.460176136203813 2730 4084526
SGTC_2030 5175110 200 µM -0.100242879878446 0.465989981069019 no 1812 0.460075752108254 2684 2831986
SGTC_3104 9120930 49.47 µM -0.100428583006015 0.465915790993759 no 1813 0.460002039257763 2654 17014836
SGTC_626 0214-0009 33 µM -0.100531946875677 0.465874496708042 no 1814 0.45996101068164 2669 3437874
SGTC_1992 st073643 23.3 µM -0.100652381138862 0.46582638319426 no 1815 0.459913206833332 2585 3161292
SGTC_1210 3013-0140 750 nM -0.101283356458603 0.46557431659959 no 1816 0.459662763934953 2695 905973
SGTC_3013 9080133 71.4286 µM -0.101711801747112 0.465403166036784 no 1817 0.459492717145985 2730 17050193
SGTC_830 4076-0286 57.8 µM -0.102050807250187 0.465267748419006 no 1818 0.459358173600828 2611 6866659
SGTC_390 dec-rvkr-cmk 16.7 µM -0.102205567375048 0.465205929969876 no 1819 0.459296754386746 2647 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1295 1013-0063 9.78 µM -0.102383815206826 0.465134730470106 no 1820 0.459226014876615 2591 6826038
SGTC_3049 9092223 49.47 µM -0.102549971195428 0.46506836195391 no 1821 0.45916007530302 2687 8623917
SGTC_876 0720-0963 56.8 µM -0.104712877764585 0.464204510708183 no 1822 0.458301821582026 2731 765861
SGTC_1144 3486-0183 12.5 µM -0.10544241234183 0.463913177045323 no 1823 0.458012381717233 2621 6744069
SGTC_250 brefeldin a 552.239 µM -0.105926429768981 0.46371989931452 no 1824 0.457820362055567 2579 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.107501456858193 0.463091019349838 no 1825 0.457195584807965 2669 5379071
SGTC_964 1287-0107 19.4 µM -0.108012926066771 0.462886818664254 no 1826 0.456992719340974 2688 51516812 YPR165W RHO1
SGTC_338 4055-0136 114 µM -0.109257730761649 0.462389879625422 no 1827 0.456499035896705 2593 2900563
SGTC_2344 7990960 76.95 µM -0.109453545471106 0.462311713670959 no 1828 0.456421382834128 2639 140813
SGTC_1628 st004252 77.7 µM -0.109833663474358 0.462159981084204 no 1829 0.456270646475688 2709 692968
SGTC_41 0478-0632 82.643 µM -0.109994772864298 0.462095672334903 no 1830 0.456206760205584 2594 3750424
SGTC_2276 7947513 42.08 µM -0.110786323747641 0.461779729711722 no 1831 0.455892895327439 2685 2105100
SGTC_2003 4023581 200 µM -0.110826735099873 0.461763600416621 no 1832 0.455876872199662 2689 16641307
SGTC_15 0266-0086 27.098 µM -0.112553314833795 0.461074533486611 no 1833 0.455192349565108 2631 1712902 YIL048W NEO1
SGTC_2198 6589944 200 µM -0.112809441594193 0.460972324837452 no 1834 0.45509081640991 2645 5290268
SGTC_2312 7706453 155.7 µM -0.114184451742469 0.460423664482332 no 1835 0.454545788501623 2640 976098
SGTC_1682 st012968 530 nM -0.116103100822447 0.459658205952581 no 1836 0.453785415667629 2633 24207270
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.117638523445388 0.459045745871739 no 1837 0.453177039782499 2629 65057 A dermal irritant. YDR527W RBA50
SGTC_1782 st039423 80.636 µM -0.118345502025954 0.45876377391759 no 1838 0.452896952645609 2660 2068169
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.120182717577852 0.458031114622812 no 1839 0.452169203956284 2636 689007
SGTC_1512 0259-0544 12.2 µM -0.120270659287442 0.457996048090869 no 1840 0.452134372933738 2623 18476
SGTC_3086 9117350 49.47 µM -0.120383599869335 0.457951013802086 no 1841 0.452089641162563 2618 2679265
SGTC_1531 st059297 52.4 µM -0.120749942765295 0.457804940782529 no 1842 0.451944549883212 2718 7566702
SGTC_2731 amoxapine 43.43 µM -0.121088678867916 0.457669880574567 no 1843 0.451810398073352 2612 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1370 2001-0092 44.6 µM -0.122271079993095 0.457198474281296 no 1844 0.451342167470978 2697 790957
SGTC_2417 cerulenin 830 nM -0.12359941998555 0.456668956120738 no 1845 0.450816225875045 2603 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1499 4480-0877 67.3 µM -0.124000712208994 0.456509003489206 no 1846 0.450657355577489 2627 2861909
SGTC_2385 9074692 200 µM -0.125072369799683 0.456081881920471 no 1847 0.450233128605373 2661 17046906
SGTC_1652 st011932 78 µM -0.126223892275395 0.455622985847659 no 1848 0.449777349659703 2637 1551076
SGTC_1886 st057356 49.9 µM -0.12633207826153 0.455579875415149 no 1849 0.4497345324447 2619 24207747
SGTC_1171 0368-0077 21.4 µM -0.126967327992589 0.455326748847994 no 1850 0.449483128854864 2626 3239779
SGTC_926 2268-1401 59.4 µM -0.127334215955084 0.455180564061168 no 1851 0.449337940147845 2636 2931578
SGTC_779 1360-0071 233 µM -0.128371458835608 0.454767312399583 no 1852 0.448927508402087 2825 7566
SGTC_1693 xanthone 101.9 µM -0.128891697735751 0.454560060555469 no 1853 0.448721673059022 2673 7020 An insecticide.
SGTC_1226 3909-7979 35.4 µM -0.129089358174789 0.45448132018238 no 1854 0.448643471249171 2756 6615510
SGTC_3250 9135583 49.47 µM -0.130494876865804 0.453921466953527 no 1855 0.448087453577279 2773 7699353
SGTC_1052 3253-3998 198 µM -0.130973009316638 0.45373103565904 no 1856 0.447898329448899 2624 5450317
SGTC_709 3807-1509 243 µM -0.131344655483019 0.453583023223584 no 1857 0.447751333889601 2619 1886677 YPL242C IQG1
SGTC_2818 7996756 12.99 µM -0.131542319027942 0.45350430402847 no 1858 0.447673155826338 2635 2241621
SGTC_1985 st071382 65.5 µM -0.132058968058448 0.453298558002132 no 1859 0.44746882517181 2643 6123237
SGTC_2426 5582046 32.21 µM -0.132771586229448 0.453014791430443 no 1860 0.447187013139776 2766 2251934
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.132839139601069 0.452987892729464 no 1861 0.44716029986003 2744 6708739 YPR165W RHO1
SGTC_3157 9099274 49.47 µM -0.13326776130922 0.452817227269262 no 1862 0.446990811444476 2665 17217662
SGTC_1802 st050112 57.9 µM -0.13372831012331 0.452633859021799 no 1863 0.446808708993201 2616 4662563
SGTC_180 1486-1293 102.781 µM -0.134152007744031 0.452465172056178 no 1864 0.446641187523814 2663 4140536
SGTC_2954 9074818 52.69 µM -0.13502428802113 0.452117917678616 no 1865 0.446296335557484 2751 16648742
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.135096377537661 0.452089220510175 no 1866 0.446267837114553 2756 521171
SGTC_3126 9127922 49.47 µM -0.135132821547468 0.452074713088403 no 1867 0.446253430166496 2895 45595682
SGTC_3241 9133421 49.47 µM -0.135825844873281 0.451798850549989 no 1868 0.445979479571446 2626 17018221
SGTC_2356 9061756 188.97 µM -0.135946861425666 0.451750681490406 no 1869 0.445931644635574 2686 20104043
SGTC_462 ag-879 158 µM -0.136773835580763 0.451421534267537 no 1870 0.44560478271854 2734 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2556 citropten 84.59 µM -0.137806204380491 0.451010684009174 no 1871 0.445196790380583 2644 2775 A potential DNA crosslinker.
SGTC_1710 st031758 61.5 µM -0.138135175789428 0.450879774757273 no 1872 0.445066792993515 2803 5394341
SGTC_1428 4049-0204 61.7 µM -0.140117836350876 0.450090918274945 no 1873 0.444283444122634 2759 X1428
SGTC_45 0kpi-0036 14.9 µM -0.140561604569766 0.449914379676533 no 1874 0.444108141064524 2758 2795021
SGTC_1179 1021-1431 9.29 µM -0.140982640523305 0.44974689352491 no 1875 0.443941828107839 2740 2840958
SGTC_1252 0493-0875 34.8 µM -0.142978378283545 0.448953120567918 no 1876 0.443153628681261 2646 3960963
SGTC_2876 9059903 25.97 µM -0.143805357312463 0.448624262488213 no 1877 0.442827086163956 2651 6916095
SGTC_739 1486-1183 203 µM -0.144105487678954 0.448504920784164 no 1878 0.442708585707025 2676 4346692
SGTC_723 4182-0001 115 µM -0.144708196033968 0.448265278206301 no 1879 0.44247063388921 2694 744821 YLR208W SEC13
SGTC_420 mitomycin C 81.9 mM -0.14542705540885 0.44797947757018 no 1880 0.442186852299497 2666 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3009 9080819 71.4286 µM -0.145604927459667 0.447908764221345 no 1881 0.442116638947677 2732 17027216
SGTC_2693 st077581 40.7 µM -0.146684797639408 0.447479495531268 no 1882 0.441690409262621 2678 25238761
SGTC_2844 9010103 25.97 µM -0.14680453292326 0.447431902284971 no 1883 0.441643153348818 2848 2480525
SGTC_762 1165-0429 115 µM -0.146867914217138 0.447406709336374 no 1884 0.441618138995395 2785 5967793
SGTC_317 4495-0002 170 µM -0.146868209189609 0.447406592090505 no 1885 0.441618022580745 2713 15991618
SGTC_2036 5160441 105 µM -0.147640201272769 0.447099755901168 no 1886 0.441313363361797 2708 134534 YIL048W NEO1
SGTC_182 3448-4371 550.524 µM -0.148165718407423 0.44689090181479 no 1887 0.441105992952939 2645 3491403
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.148281006070872 0.446845085486828 no 1888 0.441060502302954 2623 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1646 st011709 75.6 µM -0.149045373098856 0.446541337303881 no 1889 0.440758915117118 2688 5757843
SGTC_219 mitoxanthrone 164.414 µM -0.14929915903987 0.446440493440602 no 1890 0.440658789412626 2741 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2582 agaric acid 100 µM -0.150704113513199 0.445882286441188 no 1891 0.440104564092619 2747 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.151398189798963 0.44560656026073 no 1892 0.439830808667619 2658 97141
SGTC_2708 st078559 56 µM -0.152729258780802 0.445077858426645 no 1893 0.439305893139573 2696 17250902
SGTC_2944 9067346 25.62 µM -0.152795497976768 0.445051550700219 no 1894 0.439279774070423 2822 6473075
SGTC_2801 7907800 81.82 µM -0.153291422572909 0.444854595731007 no 1895 0.439084232264486 2765 6620925
SGTC_1084 voriconazole 435 nM -0.153788235489586 0.444657301617739 no 1896 0.438888355100728 2695 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3230 9131665 49.47 µM -0.15388553063877 0.444618665417462 no 1897 0.438849996540857 2665 15943720
SGTC_2050 5263056 171 µM -0.155066592100569 0.44414970438023 no 1898 0.438384409603601 2776 763468 YGL055W OLE1
SGTC_2282 7944268 200 µM -0.155885451155531 0.443824607977107 no 1899 0.438061656702668 2824 2970414
SGTC_2976 9009005 19.48 µM -0.157899874183856 0.443025020327759 no 1900 0.437267848603638 2880 2993148
SGTC_3332 9141069 11.198 µM -0.158529834906458 0.442775016630089 no 1901 0.437019656526013 2683 17332883
SGTC_33 0986-0033 35.816 µM -0.159145953762481 0.442530528197456 no 1902 0.436776941843841 2681 2848082
SGTC_463 ikarugamyin 104 µM -0.159676264046085 0.442320107864884 no 1903 0.436568049758495 2680 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2295 7971645 200 µM -0.159753615593014 0.442289417119583 no 1904 0.436537582043097 2772 2978226 YKL099C UTP11
SGTC_2264 7948757 110.76 µM -0.160551518055775 0.441972853895284 no 1905 0.436223321190596 2673 2971411
SGTC_1660 st012960 28.1 µM -0.160759552007837 0.441890323700368 no 1906 0.43614139181016 2770 24207266
SGTC_2187 6125751 200 µM -0.161225509245334 0.441705480619828 no 1907 0.435957895230951 2735 874498
SGTC_395 anisomycin 6.25 µM -0.161762491175583 0.441492478118937 no 1908 0.435746445827318 2748 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_499 genistein 192 µM -0.162185407709938 0.44132473339541 no 1909 0.435579925311384 2748 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1700 st030840 7.9285 µM -0.162595051527711 0.441162263168412 no 1910 0.435418641726613 2806 5499307
SGTC_2134 5324836 1.464 µM -0.163141983842239 0.440945357923823 no 1911 0.435203322127265 2740 699272
SGTC_860 0443-0016 25.1 µM -0.165664587879729 0.439945160845461 no 1912 0.43421045784148 2713 5337942
SGTC_1243 0416-0003 5.65 µM -0.166428741902581 0.439642253766188 no 1913 0.433909778295866 2770 2141977
SGTC_2968 9090663 33.37 µM -0.168136773636581 0.438965325982789 no 1914 0.433237839981697 2806 25236811
SGTC_2347 9049783 174.81 µM -0.169460030817064 0.438441014784125 no 1915 0.4327174042102 2844 6467988 YPL169C MEX67
SGTC_415 dibenzyl ketone 100 µM -0.169571696188803 0.438396774796259 no 1916 0.432673491653929 2794 7593
SGTC_2575 plumbagin 510 nM -0.171017306975846 0.43782411720857 no 1917 0.432105078535889 2673 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_517 1365-0151 113 µM -0.17146646777591 0.43764621517612 no 1918 0.431928497390214 2872 768657
SGTC_537 1334-0398 209 µM -0.172370214062409 0.437288300749548 no 1919 0.431573243705083 2760 5846986
SGTC_435 c-PAF 6.7 µM -0.172902332606744 0.43707758759684 no 1920 0.431364099057531 2799 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_533 1222-0222 6.71 µM -0.174389411969158 0.436488815175314 no 1921 0.430779717425557 2894 3982874
SGTC_2368 9071271 200 µM -0.175094114626523 0.436209854575843 no 1922 0.430502841341518 2741 27209959
SGTC_771 0250-0039 27.3 µM -0.175855931854899 0.43590832053776 no 1923 0.430203563502142 2712 3005115
SGTC_1957 st077035 62.4 µM -0.175906640848795 0.435888250787123 no 1924 0.430183644032199 2727 705593
SGTC_3316 9136639 10.545 µM -0.176554832231937 0.435631722308236 no 1925 0.429929037635405 2811 4903665
SGTC_411 enrofloxacin 100 µM -0.176606056350278 0.435611450984106 no 1926 0.429908918293775 2871 71188 A bacterial gyrase inhibitor.
SGTC_1955 wogonin 32.4 µM -0.177722041677945 0.435169855397047 no 1927 0.429470637028693 2970 5281703 A flavanone.
SGTC_174 3553-0389 74.3 µM -0.177987034724119 0.435065009459816 no 1928 0.42936657897725 2857 738071
SGTC_2048 5246248 200 µM -0.179799841773878 0.434347885330972 no 1929 0.4286548539193 2767 677046
SGTC_2258 7960471 200 µM -0.180758599124945 0.433968699907563 no 1930 0.428278530417324 2776 2974708
SGTC_2551 apiole 73.87 µM -0.180945692749025 0.433894712059638 no 1931 0.42820510157019 2711 10659 A possible DNA adduct former.
SGTC_1446 4239-0190 62 µM -0.181076659973708 0.433842921276531 no 1932 0.428153702193704 2741 1340085
SGTC_3089 9117425 49.47 µM -0.181650855597599 0.433615869936717 no 1933 0.427928367867495 2803 9401657
SGTC_3134 9127454 49.47 µM -0.182339132962942 0.433343736688874 no 1934 0.427658294875622 2729 24262820
SGTC_1625 st003711 30.1 µM -0.182669132289803 0.433213271727237 no 1935 0.427528818530949 2915 24207034 YER133W GLC7
SGTC_2849 9019321 12.99 µM -0.182949026622197 0.433102621437714 no 1936 0.427419007165794 2854 16489627
SGTC_1530 rhein 70.4 µM -0.183344850736078 0.432946149721589 no 1937 0.427263722495402 2710 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3237 9133362 49.47 µM -0.184491989887447 0.432492737997855 no 1938 0.426813755224587 2833 43845137
SGTC_2647 atorvastatin 60.16 µM -0.184816516360446 0.432364483605336 no 1939 0.426686476421569 2809 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_945 3381-0768 11.3 µM -0.18497216979065 0.432302971163631 no 1940 0.426625432084256 2822 1126236 YIL048W NEO1
SGTC_2696 st077691 74.316 µM -0.185407341572802 0.432131005001968 no 1941 0.426454775255449 2878 757133
SGTC_2679 rapamycin 1 nM -0.185515225902552 0.432088374505516 no 1942 0.42641246949935 2793 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2846 9008642 19.48 µM -0.185650469293001 0.432034934192323 no 1943 0.426359436358521 2867 2992898
SGTC_2002 4023503 131 µM -0.185848877434508 0.431956537098056 no 1944 0.426281636763603 2773 4736863 YCR052W RSC6
SGTC_3097 9117246 49.47 µM -0.186359811376307 0.431754663891821 no 1945 0.426081303088428 2718 16423892
SGTC_337 1315-0038 354 µM -0.186399479284774 0.431738991597116 no 1946 0.426065750372354 2749 1626437
SGTC_2770 toltrazuril 17.5 µM -0.186740741798891 0.431604167484898 no 1947 0.42593195530566 2721 68591 Kills coccidiodes.
SGTC_886 0866-0150 153 µM -0.187013058592065 0.43149658778258 no 1948 0.425825197150378 2923 271463
SGTC_3017 9080681 49.47 µM -0.187766057221678 0.431199139512034 no 1949 0.425530022437319 2817 16451914
SGTC_2759 disulfiram 3.38 µM -0.189026123879245 0.430701477422726 no 1950 0.425036170988587 2737 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2851 9015922 71.43 µM -0.190412607658402 0.430154014183333 no 1951 0.424492909462097 2921 2996893
SGTC_2321 7390090 138.78 µM -0.19111141626012 0.429878135322804 no 1952 0.424219151802216 2831 649046
SGTC_1004 4084-0029 199 µM -0.191536264002516 0.429710428709581 no 1953 0.424052735930758 2889 716894 YLR208W SEC13
SGTC_1896 st058441 89 µM -0.192963119723545 0.429147277238437 no 1954 0.423493925709332 2777 688759
SGTC_1876 myriocin 605 nM -0.193191037185812 0.429057336090999 no 1955 0.423404678902572 2867 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1588 farnesol 29.9 µM -0.193510923147591 0.428931108403215 no 1956 0.423279426148946 2753 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2194 5927483 104.545 µM -0.193643224561245 0.428878904105073 no 1957 0.423227625214914 2735 760979
SGTC_1698 5-fluorocytosine 1.055 µM -0.193788594335992 0.428821544647968 no 1958 0.423170709060705 2842 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1282 0886-0010 32.4 µM -0.195077332623362 0.428313105030428 no 1959 0.422666203804446 2885 2836211 YNL267W PIK1
SGTC_1 0258-0098 57.368 µM -0.195488152839832 0.428151051106551 no 1960 0.422505405715098 2813 6790032 YDR047W HEM12
SGTC_2027 5150920 200 µM -0.195981232529785 0.42795656475496 no 1961 0.422312427708689 2834 786715
SGTC_13 0199-0087 65 µM -0.196134531760983 0.427896102214353 no 1962 0.422252434348647 2747 4589825
SGTC_1983 st071813 46.9 µM -0.196357976826982 0.427807976583374 no 1963 0.422164992781805 2816 11838595
SGTC_2779 methotrexate 400 µM -0.197017800558877 0.427547766394831 no 1964 0.421906803978501 2783 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2340 7987427 183.45 µM -0.19712558160523 0.427505264509305 no 1965 0.421864632477495 2877 2239331
SGTC_2670 beta-carotene 100 µM -0.198378784197123 0.427011144209771 no 1966 0.421374357668641 2839 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_146 3448-8650 53.125 µM -0.198695878662571 0.426886136406448 no 1967 0.421250324049058 2796 2891488 YIL048W NEO1
SGTC_1623 st003709 20.3 µM -0.200118757324385 0.426325287086165 no 1968 0.420693851928444 2747 16192618
SGTC_780 0109-0199 192 µM -0.200134645668061 0.426319025292116 no 1969 0.420687639065218 2945 610414
SGTC_2106 5357045 167.29 µM -0.200697213693205 0.426097322213153 no 1970 0.420467669270089 2868 668842
SGTC_592 k241-0073 46.5 µM -0.200968268268224 0.425990510337614 no 1971 0.42036169304754 2869 4230158
SGTC_1961 st076550 68.7 µM -0.20334578589472 0.425053858304147 no 1972 0.419432385517574 2892 1579337
SGTC_1777 st045864 34.765 µM -0.203584110626234 0.424959990607378 no 1973 0.419339255492687 2763 4691462
SGTC_905 2-aminofluorene 215 µM -0.203784262770847 0.424881161031429 no 1974 0.419261045639327 2768 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.204321762434405 0.424669482591767 no 1975 0.419051032357955 2923 23847180
SGTC_2531 methyl deoxycholate 70.07 µM -0.205182905104845 0.424330392173025 no 1976 0.418714612528648 2774 16667744 Haematoxylin.
SGTC_1925 st057770 10.1 µM -0.206431742838149 0.423838739408873 no 1977 0.418226838783349 2759 5989122
SGTC_2978 9011784 42.97 µM -0.20675674379419 0.423710809751167 no 1978 0.418099919795002 2910 2994934
SGTC_2104 5389443 200 µM -0.207240939362734 0.423520231464005 no 1979 0.417910848136337 2948 2244536
SGTC_651 3253-0966 34.4 µM -0.207418231667763 0.423450454083499 no 1980 0.41784162269127 2805 781462
SGTC_1750 st081859 2.357 µM -0.207516929083452 0.423411610532251 no 1981 0.417803086461547 2803 5291695
SGTC_2797 7859098 81.82 µM -0.210132327410921 0.422382561503966 no 1982 0.416782197537911 2799 972681
SGTC_2751 anetholtrithion 17.25 µM -0.210882653017712 0.422087437443715 no 1983 0.416489420312392 2923 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1289 0976-0073 69.1 µM -0.211344417865351 0.421905834139495 no 1984 0.416309262577955 2890 3391136
SGTC_2218 6965428 192.983 µM -0.211729171813073 0.421754530433205 no 1985 0.416159164101818 2769 675684
SGTC_1550 gossypolone 36.6 µM -0.212013890270626 0.421642572914348 no 1986 0.416048098890905 2787 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_820 1582-0060 59.9 µM -0.212853648435579 0.4213123985765 no 1987 0.41572055851356 2833 3848840
SGTC_758 0868-0029 16 µM -0.214263786150149 0.420758088178371 no 1988 0.415170678348178 2913 762687
SGTC_368 fentichlor 4.58 µM -0.214861633136772 0.420523128125611 no 1989 0.414937599285594 2863 7329 A pesticide.
SGTC_2715 st079500 56.4 µM -0.21645195137367 0.419898254651267 no 1990 0.414317737290644 2753 28246688
SGTC_1205 4161-2785 76 µM -0.217240744706771 0.419588393983511 no 1991 0.414010366555895 2918 3498106
SGTC_1626 st003712 1.76 µM -0.218507706646968 0.419090799378938 no 1992 0.41351677717709 2951 24207035
SGTC_2707 st078556 66.6 µM -0.21979223459186 0.418586437882741 no 1993 0.413016483831127 2878 17250899
SGTC_2512 diallyl trisulfide 49.23 µM -0.21993609471233 0.418529960464223 no 1994 0.412960462485928 2777 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3031 9088762 49.47 µM -0.220343926133443 0.418369860834408 no 1995 0.41280165629185 2754 205253
SGTC_127 0180-0333 59.125 µM -0.222063083344752 0.41769513183321 no 1996 0.412132387801344 2762 771601
SGTC_967 1306-0166 352 µM -0.223132019506751 0.417275721388619 no 1997 0.411716379265735 2939 4437607
SGTC_264 promethazine 12.5 mM -0.223452885871408 0.417149843808298 no 1998 0.411591523845473 2823 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_705 1124-0212 310 µM -0.223757095342173 0.417030508657815 no 1999 0.41147315821704 2904 9554485
SGTC_545 4218-0007 221 µM -0.224217324086039 0.416849984871845 no 2000 0.411294101974877 2923 2840508
SGTC_3352 9151559 45.5865 µM -0.225061483826647 0.416518910532033 no 2001 0.410965721884204 2890 17159339
SGTC_1821 st053465 65.6 µM -0.225428907598067 0.416374827634218 no 2002 0.410822812659732 2876 675086
SGTC_3228 9131799 49.47 µM -0.225452602269931 0.416365536304631 no 2003 0.410813597039397 2864 17015818
SGTC_807 1315-0151 48 µM -0.225621958045008 0.416299128629348 no 2004 0.41074773056264 3029 4011080
SGTC_1964 st076914 61 µM -0.227149979967913 0.415700069926382 no 2005 0.410153560613509 2789 24208661
SGTC_1054 3429-0080 167 µM -0.227579161203103 0.415531845238141 no 2006 0.40998671091055 2981 1162877
SGTC_2865 9030313 51.95 µM -0.227771504880715 0.415456457972039 no 2007 0.409911940128366 2784 42562754
SGTC_10 0279-0212 42.575 µM -0.229391239698797 0.414821742097092 no 2008 0.409282422180993 2839 39851 YBR002C RER2
SGTC_1352 1496-0991 99 µM -0.229979853677354 0.414591140411297 no 2009 0.409053712298366 2796 3000039
SGTC_1266 0828-0227 32.9 µM -0.230437016191019 0.414412057855074 no 2010 0.408876100113933 2931 3913820
SGTC_2168 5727979 200 µM -0.233115805446771 0.413363064496785 no 2011 0.407835741001719 2759 695210
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.233341936559903 0.413274541472847 no 2012 0.407747948281033 3012 688798
SGTC_1560 lithocholic acid 53.1 µM -0.233430331135112 0.413239939051164 no 2013 0.407713631395449 2818 9903 A bile acid which acts as a detergent.
SGTC_509 pifithrin 175 µM -0.233485991781312 0.413218150807004 no 2014 0.407692022966323 2857 4817 A p53 inhibitor.
SGTC_75 0159-0059 199.013 µM -0.233981486090681 0.4130242023779 no 2015 0.407499675857966 3128 5377270
SGTC_417 st075190 100 µM -0.235273417593239 0.412518609152798 no 2016 0.406998262891035 2962 222757
SGTC_2941 9056145 11.23 µM -0.236030567201229 0.41222236848875 no 2017 0.406704475489968 2794 2119517
SGTC_17 0960-0276 49.807 µM -0.237684820680726 0.411575303170174 no 2018 0.406062778835089 2826 6821114
SGTC_322 k048-0136 19.3 µM -0.238870050123619 0.411111845483099 no 2019 0.405603174949145 2920 6823282
SGTC_1806 st050005 60.3 µM -0.2409832719133 0.410285825091976 no 2020 0.40478404080012 2832 5194765
SGTC_976 1348-1067 47.6 µM -0.242126712031929 0.409839040556439 no 2021 0.404340990346756 2853 5310671 YGL099W LSG1
SGTC_2790 5423970 71.43 µM -0.242626587509775 0.409643757368269 no 2022 0.404147341343285 3011 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1208 2323-2347 50.3 µM -0.242712266903571 0.409610287790772 no 2023 0.40411415197501 2996 5412760
SGTC_738 1315-0003 72.4 µM -0.242886245291009 0.409542327349112 no 2024 0.404046760615831 2999 6251474
SGTC_2292 7671323 168.05 µM -0.242932260894656 0.409524352922913 no 2025 0.404028936728139 2985 937504
SGTC_2726 cimetidine 79.27 µM -0.243463136164859 0.40931699836656 no 2026 0.403823319568152 2827 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.243981811298052 0.409114433561374 no 2027 0.403622453396481 2954 16725076
SGTC_2946 9065502 71.43 µM -0.245143975456669 0.408660646975854 no 2028 0.403172477008881 2857 16489101
SGTC_2395 5646831 180.19 µM -0.246113213573409 0.408282285215148 no 2029 0.402797297334463 3016 6808628
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.246278330820897 0.408217836861144 no 2030 0.402733391472161 2898 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2724 maprotiline 69.64 µM -0.248519879135603 0.407343164900447 no 2031 0.401866095555412 2899 4011 A tricyclic antidepressant.
SGTC_206 4546-0025 72.014 µM -0.248948162714613 0.407176097275599 no 2032 0.401700439663426 2901 6620745 YIL048W NEO1
SGTC_2884 9058502 51.95 µM -0.251303948466974 0.406257439829955 no 2033 0.400789561333444 2952 6471554
SGTC_2001 4023502 57.655 µM -0.254868803604671 0.404868278470345 no 2034 0.399412215920568 2982 108941 YCR052W RSC6
SGTC_646 4092-0839 27.3 µM -0.255443584801397 0.404644408044455 no 2035 0.399190255616995 2996 877796
SGTC_3113 9123498 49.47 µM -0.256217795548012 0.404342911531849 no 2036 0.398891334148591 2828 8897275
SGTC_2444 5485484 36.41 µM -0.256960063992643 0.404053907458738 no 2037 0.398604801218477 2982 6790631
SGTC_1960 st011366 51.8 µM -0.260485546401362 0.402681969586762 no 2038 0.397244631453621 2836 3972846
SGTC_519 k048-0011 62.8 µM -0.262341172002724 0.401960334730001 no 2039 0.396529211276401 2989 6836379
SGTC_62 0180-0423 3.232 µM -0.264295845579044 0.401200542417806 no 2040 0.395775980625689 2899 30102 YGL099W LSG1
SGTC_2775 cyproheptadine 69.59 µM -0.264941550342726 0.400949635365828 no 2041 0.395527244574178 2960 2913 A selective serotonin reuptake inhibitor.
SGTC_520 3584-0023 682 µM -0.265988299960148 0.400542977698014 no 2042 0.395124109913989 2931 1340790
SGTC_2464 5717415 7.67 µM -0.266168338248637 0.40047304445791 no 2043 0.395054783071293 2882 5285744
SGTC_3074 9116018 49.47 µM -0.269190405953597 0.399299644386699 no 2044 0.393891581407652 2849 17027303
SGTC_1755 st041960 45.185 µM -0.269371942479548 0.39922918673089 no 2045 0.393821737548399 3004 2257073
SGTC_2783 7738165 71.43 µM -0.26967709968028 0.399110757021181 no 2046 0.393704339910682 2951 17201110
SGTC_1733 st037357 54.9 µM -0.270601767926826 0.398751955469452 no 2047 0.393348667967631 2838 1272339 YGL099W LSG1
SGTC_677 0929-0063 136 µM -0.272281788927148 0.398100271439186 no 2048 0.392702678880385 2909 1539583
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.272446784587584 0.39803628453586 no 2049 0.39263925189001 2897 4174840
SGTC_1754 st042065 16.137 µM -0.272569139158065 0.39798883602783 no 2050 0.392592218662672 2927 1126236 YIL048W NEO1
SGTC_2025 5147754 141 µM -0.273442866853588 0.397650052564374 no 2051 0.392256402436491 2976 315777 YLR208W SEC13
SGTC_2099 5377090 177.372 µM -0.275100379407828 0.397007572787881 no 2052 0.39161956004903 2975 2243829
SGTC_2155 5570423 76 µM -0.275639574234902 0.39679863194197 no 2053 0.391412455422162 2911 797402
SGTC_2093 5331342 194.4 µM -0.276582448573981 0.39643333438032 no 2054 0.391050371575913 3035 33839
SGTC_1486 3970-0793 4.53 µM -0.277128213228076 0.396221930433847 no 2055 0.390840829435943 2991 2844330
SGTC_85 0868-0259 160.055 µM -0.278622178451186 0.395643393763605 no 2056 0.390267395258555 2945 83173
SGTC_2404 5161160 200 µM -0.279363122163826 0.395356549177138 no 2057 0.389983084557687 2838 2831543
SGTC_540 1187-0821 17.3 µM -0.279541007384763 0.39528769217249 no 2058 0.389914836207995 2895 847520
SGTC_3239 9133757 49.47 µM -0.279753875354234 0.395205298107896 no 2059 0.389833170659393 2882 17036923
SGTC_1423 4048-0112 5.59 µM -0.280110111224072 0.395067421611252 no 2060 0.389696513737035 2980 X1423
SGTC_1872 amphotericin b 148 nM -0.280211661964071 0.39502812011332 no 2061 0.389657559989555 3031 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_441 propafenone 146 µM -0.280212359019804 0.395027850347096 no 2062 0.389657292610469 2881 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.280404983216958 0.394953305148511 no 2063 0.389583407146088 2856 5355888
SGTC_770 0389-1121 67.2 µM -0.280416993488724 0.39494865732346 no 2064 0.389578800460809 3080 6753108
SGTC_1297 1068-0111 14.1 µM -0.28222749766159 0.394248186177742 no 2065 0.388884537446328 2913 767057
SGTC_2505 galangin 7.89 µM -0.283607582459351 0.393714470714761 no 2066 0.388355562827875 2858 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1028 k015-0029 4.8 µM -0.285407026157591 0.393018877942854 no 2067 0.387666162603684 2892 4588309
SGTC_857 0438-0306 1.35 µM -0.285511633719653 0.392978451334969 no 2068 0.387626096375244 3010 4686136
SGTC_1697 st025554 27.742 µM -0.286389114756243 0.392639385759694 no 2069 0.387290055443418 2889 1269519
SGTC_1045 1348-1485 165 µM -0.286478664365796 0.392604787662909 no 2070 0.387255766188125 2893 6810614
SGTC_1501 4491-0275 38.4 µM -0.286830503933715 0.392468860288348 no 2071 0.387121052548778 3008 5104718
SGTC_2828 7998861 71.43 µM -0.287105908412556 0.39236247149225 no 2072 0.387015614144425 3028 2988188
SGTC_2920 7982904 15.77 µM -0.287346862866648 0.392269397343939 no 2073 0.386923371744423 3025 6456808
SGTC_2147 5545932 89.7195 µM -0.288735039834106 0.391733302538446 no 2074 0.386392073127932 2946 797404
SGTC_564 3555-0129 330 µM -0.289753928401131 0.391339952541895 no 2075 0.386002248130697 2933 563260
SGTC_1135 dihydrocapsaicin 536.708 nM -0.291287578086573 0.390748084521488 no 2076 0.385415693499162 2865 107982 A Capsaicinoid.
SGTC_2836 9010338 19.48 µM -0.293105389348945 0.390046880268105 no 2077 0.384720798744756 2931 2994051
SGTC_2657 nystatin 74.44 µM -0.294655104091295 0.389449374116302 no 2078 0.384128681459974 2984 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1418 3966-3099 2.4 µM -0.295645030874407 0.389067835784384 no 2079 0.383750590185893 3018 740335
SGTC_2335 9018011 154.17 µM -0.296999703030004 0.388545890388747 no 2080 0.383233367930288 3025 6458208
SGTC_1090 efavirenz 20.7 µM -0.298180119025196 0.388091248609391 no 2081 0.382782847363192 2976 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_225 nsc-122657 1.016 µM -0.300199197372595 0.387313948527598 no 2082 0.382012608630722 3053 275685
SGTC_3174 9107204 49.47 µM -0.300419320032755 0.387229233461708 no 2083 0.381928664322913 3068 3938802
SGTC_736 0958-0254 92.6 µM -0.303172376316631 0.386170163840771 no 2084 0.380879249724599 3049 6812352
SGTC_237 nikkomycin 200 µM -0.303545735964531 0.38602660170219 no 2085 0.380736999128765 3075 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1884 5633444 25 µM -0.305896736733902 0.385122967462845 no 2086 0.379841635327333 3107 5724239
SGTC_1766 st045414 44.774 µM -0.306371811875106 0.384940442421311 no 2087 0.379660783991488 2945 253960
SGTC_2916 7875993 68.79 µM -0.306843487093969 0.38475924885863 no 2088 0.379481252975118 3002 1299250
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.306914519774905 0.384731963904936 no 2089 0.379454218465842 3096 5282362
SGTC_912 3474-0017 2.18 µM -0.307140664617932 0.384645101331589 no 2090 0.379368153348682 3116 3360550
SGTC_2694 st077685 81.9 µM -0.307679629248221 0.384438107562026 no 2091 0.379163060888161 2898 2838096
SGTC_844 0330-0132 15.3 µM -0.308089779518762 0.38428060807248 no 2092 0.379007008999602 3072 2828079
SGTC_2359 9039622 200 µM -0.308166877005757 0.38425100443412 no 2093 0.378977677540803 2909 6463596
SGTC_231 b-estradiol 524 µM -0.311488823547624 0.382976097839655 no 2094 0.377714519051812 2955 450 A steroid.
SGTC_2935 9038016 29.96 µM -0.311523461135916 0.382962811171326 no 2095 0.377701355090559 3112 6463195
SGTC_862 0452-0056 10.2 µM -0.312441767454077 0.382610607367077 no 2096 0.37735240605761 3031 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1042 0350-0096 82 µM -0.312598216355621 0.382550613204168 no 2097 0.377292966703021 2942 3122515
SGTC_1893 st059353 36.1 µM -0.314910601548286 0.381664201903643 no 2098 0.37641476598731 3022 3112488
SGTC_2078 5212016 200 µM -0.316671022931681 0.380989791528612 no 2099 0.375746619184716 2984 1899708
SGTC_2153 5569715 200 µM -0.316910537447062 0.380898062359704 no 2100 0.375655743062256 2985 2054701
SGTC_298 1391-0729 10 µM -0.317382151169543 0.38071746350334 no 2101 0.375476824485738 2958 3237558
SGTC_2181 6316240 54.2555 µM -0.317524318307753 0.380663027387575 no 2102 0.375422895042635 3044 12779990
SGTC_2457 5731572 11.68 µM -0.317706812456873 0.38059315343195 no 2103 0.375353671587326 3100 2865357
SGTC_3082 9117008 49.47 µM -0.319359490116598 0.379960548434473 no 2104 0.37472696293963 2984 41448529
SGTC_1057 3448-5381 134 µM -0.321806481798587 0.379024489271745 no 2105 0.373799651771286 3103 5497911
SGTC_291 SEC14.278 35.5 µM -0.322062795493187 0.378926481324364 no 2106 0.373702561364572 3098 1068044
SGTC_2172 5754775 163.918 µM -0.325771313655571 0.377509310723232 no 2107 0.372298692072526 2964 2263357
SGTC_374 0880-0231 82.3 µM -0.326281866289991 0.377314337088865 no 2108 0.372105553383977 3046 6833587
SGTC_1234 0326-0494 15.5 µM -0.326424316031674 0.377259942899876 no 2109 0.372051671326153 3121 1547813
SGTC_2400 5203494 178.7 µM -0.326586363251175 0.377198068408361 no 2110 0.371990379507586 2956 6777674
SGTC_763 3453-1109 128 µM -0.327879166326722 0.37670455042531 no 2111 0.371501513308671 3132 1560353
SGTC_733 4069-0007 56.1 µM -0.327897646039694 0.376697497390279 no 2112 0.371494526809495 3009 5717425 YNL287W SEC21
SGTC_3178 9107506 49.47 µM -0.329031661127663 0.376264763870252 no 2113 0.37106587854174 3135 8897194
SGTC_1012 4112-3522 18 µM -0.329521809949041 0.376077774045885 no 2114 0.370880655832334 3147 3112398
SGTC_1276 0871-0068 94.2 µM -0.330573813777783 0.375676537041429 no 2115 0.370483214361754 3065 3414906
SGTC_314 1671-0008 2.74 µM -0.333664573026516 0.374498492406954 no 2116 0.369316342780307 2981 3913060
SGTC_82 0054-0107 293.755 µM -0.334091003545248 0.374336049818218 no 2117 0.369155444283007 3056 3104697
SGTC_2211 7117706 200 µM -0.334200437831112 0.374294365992362 no 2118 0.36911415681462 3091 822771
SGTC_2832 7992762 51.95 µM -0.335419037480905 0.373830297361106 no 2119 0.368654504538537 2941 2985177
SGTC_1182 1222-0449 220 µM -0.336552341171179 0.373398875311194 no 2120 0.368227194218729 3064 658318
SGTC_1414 3917-0015 5.4 µM -0.337889008989766 0.372890241245441 no 2121 0.367723415257752 3105 6618702
SGTC_727 3032-0951 202 µM -0.338460460817693 0.372672857701043 no 2122 0.367508109194 3057 3652836
SGTC_1064 honokiol 6.76 µM -0.338538306208522 0.372643248005579 no 2123 0.367478782585584 3076 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3229 9132204 49.47 µM -0.338834707087242 0.372530514247771 no 2124 0.367367126883647 3001 17682924
SGTC_1079 idarubicin 2.36 µM -0.339164870080444 0.372404952190229 no 2125 0.367242766025489 3138 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2452 5863136 48.41 µM -0.339730899439445 0.372189720949531 no 2126 0.367029594959596 2965 2184096
SGTC_2041 5107442 45.335 µM -0.339929492664255 0.37211421583222 no 2127 0.366954812914261 3166 793005
SGTC_189 3970-0742 2.116 µM -0.341627781994973 0.371468727543301 no 2128 0.366315513399915 3046 2891807
SGTC_675 1309-0189 238 µM -0.341812326550698 0.371398607309535 no 2129 0.366246066245406 3044 4246530
SGTC_276 colchicine 750 µM -0.341821435501101 0.371395146349469 no 2130 0.366242638510837 3146 2833 A microtubule depolymerizer.
SGTC_1058 3448-5425 97.3 µM -0.341943118250292 0.371348913794416 no 2131 0.366196849827954 3006 7279705
SGTC_936 3005-4620 401 µM -0.34313553136616 0.370895962636589 no 2132 0.365748250922899 3207 777207
SGTC_2416 tofa 880 nM -0.343178447811694 0.370879663685972 no 2133 0.365732108702812 2999 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3019 9081971 49.47 µM -0.343425807914831 0.370785724958805 no 2134 0.365639073451156 3172 16451803
SGTC_2451 5856223 45.7 µM -0.343433365890164 0.370782854824991 no 2135 0.365636230925798 3040 2179896
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.344048181471049 0.370549403298561 no 2136 0.365405025883105 3026 688669
SGTC_1606 st000094 49.2 µM -0.345838633262859 0.369869822905278 no 2137 0.364731994717788 3156 1242210
SGTC_2958 9077254 16.72 µM -0.346496603176443 0.369620187072531 no 2138 0.364484768285349 3214 16457351
SGTC_2984 9022109 38.96 µM -0.347404999966778 0.369275628816864 no 2139 0.364143538781026 3134 6459207
SGTC_1603 st002045 67.8 µM -0.350268182543347 0.368190301228715 no 2140 0.363068720637735 3144 5887985
SGTC_2283 7944793 200 µM -0.350668212627966 0.368038747975543 no 2141 0.362918637823295 3094 2970533
SGTC_3025 9087895 49.47 µM -0.35290166242575 0.367192973183194 no 2142 0.362081082242062 3149 17173641
SGTC_2718 lomofungin 53.02 µM -0.353441215266651 0.366988748837598 no 2143 0.361878845874922 3170 5351222 A RNA synthesis inhibitor.
SGTC_503 tyrphostin 8 294 µM -0.355055362976989 0.366378008086233 no 2144 0.361274057980092 3130 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2000 st075254 36.4 µM -0.355242231651723 0.366307324904089 no 2145 0.361204064490814 3030 17234175
SGTC_1432 4049-0298 68.4 µM -0.355961766235786 0.366035202913063 no 2146 0.360934599184348 3125 741646
SGTC_2261 9010538 184.68 µM -0.356093649358907 0.36598533311554 no 2147 0.360885216507023 3122 6457250
SGTC_1007 4101-0031 70 µM -0.356771098414844 0.365729200730779 no 2148 0.360631587198122 3179 1146276
SGTC_1333 1482-0047 286 µM -0.357323983308307 0.365520208359807 no 2149 0.360424638730607 3167 3811116
SGTC_881 0833-0569 170 µM -0.357949867198025 0.365283670293374 no 2150 0.360190415592739 3053 5418700
SGTC_1529 apigenin 74 µM -0.359119106614745 0.36484192113818 no 2151 0.359752994349898 3275 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_244 nsc-207895 1.295 µM -0.360495398709634 0.364322175462373 no 2152 0.359238348474899 2974 42640
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.360879736097468 0.364177078033587 no 2153 0.359094676251049 3206 1273210
SGTC_91 0417-1751 58.384 µM -0.360996252927812 0.36413309372312 no 2154 0.359051124100753 3093 6795624
SGTC_2206 7254556 146.969 µM -0.361237137418209 0.364042167142246 no 2155 0.358961091092941 3081 4398905
SGTC_2289 7946404 165.07 µM -0.362101468237159 0.363715971535355 no 2156 0.358638103249775 3006 1246120 YPR165W RHO1
SGTC_2105 5350118 200 µM -0.364912734552293 0.362655692954626 no 2157 0.357588274030726 3070 2133313
SGTC_2822 7994718 71.43 µM -0.365409023931704 0.362468624793204 no 2158 0.357403053086264 3060 1018011
SGTC_1001 4048-4355 44.4 µM -0.36603991701423 0.362230867368127 no 2159 0.357167644971812 3025 21824233
SGTC_2234 tolnaftate 200 µM -0.366140160861543 0.362193094511721 no 2160 0.357130245514311 3081 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3335 9143315 29.6265 µM -0.366164402830686 0.362183960103508 no 2161 0.357121201409773 3061 4899691
SGTC_1092 toremifene 6.32 µM -0.366845708242366 0.361927275376772 no 2162 0.356867055346727 3026 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2729 fluphenazine 10.66 µM -0.367887514362938 0.361534890573062 no 2163 0.356478555236157 3035 3372 An atypical antipsychotic.
SGTC_2043 5101342 149 µM -0.367930035072696 0.361518878705253 no 2164 0.35646270199008 3072 678451
SGTC_1739 st037196 92.5 µM -0.369946648833308 0.360759768800232 no 2165 0.355711121283106 3235 612214
SGTC_471 1-acyl-paf 4 µM -0.370485320701415 0.36055709028384 no 2166 0.355510456027414 3054 16759367
SGTC_1859 st055998 20 µM -0.371349115518534 0.36023216409396 no 2167 0.355188760056743 3253 676301
SGTC_135 0933-0004 26.348 µM -0.374423509836682 0.359076516259066 no 2168 0.354044627292615 3177 21230617 YGL099W LSG1
SGTC_2055 5235184 200 µM -0.374453074814203 0.359065409185332 no 2169 0.354033631090858 3213 2836034
SGTC_582 0987-0078 156 µM -0.374932868964013 0.35888517510834 no 2170 0.35385519665916 3209 1625765
SGTC_3077 9117319 49.47 µM -0.375321181655203 0.35873932892498 no 2171 0.35371080748694 3081 17154678
SGTC_2139 5578692 56.4705 µM -0.377012690924002 0.358104256244463 no 2172 0.353082086830713 3143 650991 YMR113W FOL3
SGTC_834 0312-0008 75.7 µM -0.377109900449103 0.358067771093015 no 2173 0.353045966981366 3067 6385573 YIL048W NEO1
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.377704012618771 0.357844814206427 no 2174 0.352825243304534 3138 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_693 4161-2696 114 µM -0.377739655926574 0.357831439618577 no 2175 0.352812002729455 3182 805759
SGTC_87 0100-0052 35.5 µM -0.378532424037998 0.357534011053475 no 2176 0.352517555802885 3190 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2809 7964133 12.99 µM -0.378677057136091 0.357479757330125 no 2177 0.352463846250556 3105 1253665
SGTC_1140 3229-1848 2.98 µM -0.380335489658742 0.356857864202963 no 2178 0.351848197226682 3175 2849525
SGTC_2018 5133068 143 µM -0.380959768020522 0.356623865406357 no 2179 0.351616550957636 3018 785362
SGTC_940 3232-1287 54.8 µM -0.381678285294524 0.356354609743943 no 2180 0.351350004355572 3159 1585493 YIL048W NEO1
SGTC_1288 0973-0013 65.5 µM -0.382172383164089 0.356169494074832 no 2181 0.351166752477072 3193 4315430
SGTC_133 0724-0033 378.92 µM -0.382531809277203 0.356034854990648 no 2182 0.351033469631477 2983 280309
SGTC_1316 1272-0050 65.9 µM -0.382675388537693 0.355981075990398 no 2183 0.350980232509755 3067 7340392
SGTC_3253 9135987 49.47 µM -0.389074510422913 0.353587146942341 no 2184 0.348610514293818 3178 4182430
SGTC_2840 9008771 71.43 µM -0.389181943509744 0.353547004999864 no 2185 0.348570779815449 3162 2992978
SGTC_523 1934-0222 13.7 µM -0.390239350873314 0.353151995943059 no 2186 0.348179782951001 3089 1361595
SGTC_1106 tegaserod maleate 11.7 µM -0.390589149115461 0.353021358797063 no 2187 0.348050473761238 3131 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2114 5491910 81.25 µM -0.392599035447636 0.352271074192866 no 2188 0.347307826037045 3215 2849228
SGTC_2275 7947463 200 µM -0.393669804288721 0.351871593759837 no 2189 0.346912418764732 3229 1225414
SGTC_1594 piperine 70.1 µM -0.394752987255868 0.351467648198383 no 2190 0.346512596827654 3090 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_104 0074-0074 590.992 µM -0.394948857934515 0.351394621096206 no 2191 0.346440315742518 3066 3943124
SGTC_1166 k206-0078 225 µM -0.395019980024822 0.351368105773314 no 2192 0.346414071330181 3084 5404595
SGTC_1183 1254-0324 198 µM -0.396582440602631 0.350785781032538 no 2193 0.34583770166593 3220 5799357
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.396585825224512 0.350784519973132 no 2194 0.345836453513783 3118 165521
SGTC_595 3909-8003 73.7 µM -0.396621146485385 0.350771359898597 no 2195 0.345823428138784 3214 699517
SGTC_931 2812-0076 566 µM -0.398036141032844 0.350244305468075 no 2196 0.34530177268087 3072 3450959
SGTC_3334 9142812 21.919 µM -0.398730231574921 0.349985877286025 no 2197 0.345045994833397 3202 45283678
SGTC_105 0111-0055 734.78 µM -0.398871743460432 0.349933197207009 no 2198 0.344993855268563 3183 5179370
SGTC_896 0964-0007 44.5 µM -0.399725310163888 0.349615504537581 no 2199 0.34467942401062 3216 6756758
SGTC_1346 1488-2224 62.4 µM -0.401038144387068 0.349127080679308 no 2200 0.34419602024843 3210 3722427
SGTC_1118 chelidonine 707.474 nM -0.401111138700403 0.349099931364564 no 2201 0.344169150190699 3213 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1502 4534-4282 27.7 µM -0.401301584984923 0.349029100906118 no 2202 0.344099048397317 3151 3278949
SGTC_2903 5923464 63.88 µM -0.401978338162736 0.348777446581716 no 2203 0.343849984184603 3204 2876576
SGTC_3276 9139060 49.47 µM -0.401985765430836 0.348774685080769 no 2204 0.343847251116602 3084 4870619
SGTC_748 act1.228 77.9 µM -0.403720773361056 0.348129818966877 no 2205 0.343209030992147 3103 4421505 YNR035C ARC35
SGTC_3354 9151612 71.43 µM -0.405462654863422 0.347482839543951 no 2206 0.342568731985779 3241 27261949
SGTC_1959 st077091 55.8 µM -0.408020559158833 0.346533573551493 no 2207 0.341629290589406 3050 821356 YKL052C ASK1
SGTC_787 4152-0075 138 µM -0.408446127708339 0.346375733723573 no 2208 0.341473086992044 3156 9566539
SGTC_2658 polymyxin b sulfate 77.05 µM -0.408913104814205 0.34620256650131 no 2209 0.341301715755468 3145 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1073 triclabendazole 3.09 µM -0.409812948386981 0.345868971857228 no 2210 0.340971583504354 3203 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2904 7225135 42.03 µM -0.41123009623131 0.345343842106582 no 2211 0.340451910899375 3239 4446116
SGTC_760 0568-0725 82.9 µM -0.411568945507417 0.345218324209282 no 2212 0.340327698614681 3243 3916171
SGTC_897 1000-0139 31.4 µM -0.412226032266885 0.344974972041696 no 2213 0.340086879101505 3270 6151020
SGTC_1619 st003326 88.7 µM -0.413849386908947 0.344374037444633 no 2214 0.339492206291703 3276 2849032
SGTC_3305 9127027 53.8275 µM -0.41641353454933 0.34342563978291 no 2215 0.338553713126192 3134 41905295
SGTC_2179 6298986 200 µM -0.416440666021639 0.343415609959679 no 2216 0.338543788192996 3245 738374
SGTC_1385 3091-4834 14.1 µM -0.417025028075515 0.343199612772822 no 2217 0.338330050598618 3224 4072814
SGTC_394 menadione 8.33 µM -0.418454212955538 0.342671560456608 no 2218 0.33780752825385 3239 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2073 5212005 126 µM -0.418492264865635 0.342657505309547 no 2219 0.337793620412269 3159 691789
SGTC_1663 st014140 55.4 µM -0.419014454024845 0.342464647505739 no 2220 0.337602784460904 3206 4207120
SGTC_2713 st079149 53.4 µM -0.420372115456448 0.341963420725691 no 2221 0.337106817586043 3210 3103253
SGTC_3296 9122258 64.045 µM -0.420674718127273 0.341851742592029 no 2222 0.336996312436819 3223 4730474
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.420732886199477 0.341830276747067 no 2223 0.336975072096076 3258 5024745
SGTC_484 loperamide 105 µM -0.421124892484579 0.341685627458297 no 2224 0.336831942745674 3155 3955 An opioid-receptor agonist.
SGTC_2600 tangeritin 87.95 µM -0.423059756440465 0.340972008591907 no 2225 0.336125831590019 3128 68077 A bioactive flavone.
SGTC_2453 5731132 22.18 µM -0.423205183904657 0.340918394801027 no 2226 0.336072782465773 3287 1362040
SGTC_684 1140-0066 328 µM -0.423839270724043 0.340684667718754 no 2227 0.335841518030166 3224 6813534
SGTC_1868 st057644 42.7 µM -0.423965050178343 0.340638312146009 no 2228 0.335795651073659 3104 688665
SGTC_1216 1165-0504 9.65 µM -0.424231358298453 0.340540173174269 no 2229 0.335698546759376 3270 6304004
SGTC_2171 5739187 198.077 µM -0.425196519380271 0.340184585765521 no 2230 0.335346710645488 3063 2262761
SGTC_1500 4488-1866 171 µM -0.426757255025538 0.339609875821142 no 2231 0.334778071645666 3299 2900003
SGTC_2196 6573537 42.6665 µM -0.427557938982639 0.339315184402017 no 2232 0.334486497029138 3277 2903087
SGTC_1605 st000082 49.1 µM -0.428059294007954 0.339130710887643 no 2233 0.334303975919505 3251 1114022
SGTC_644 1498-1197 63.3 µM -0.428246049304971 0.339062004155578 no 2234 0.334235996616022 3257 6741615
SGTC_3309 9129340 25.759 µM -0.428278698119687 0.339049993300915 no 2235 0.334224112940081 3184 17158987
SGTC_980 1473-0395 201 µM -0.428804217210966 0.338856687712909 no 2236 0.334032854790052 3118 768876
SGTC_1832 st054113 55 µM -0.430309473139591 0.338303233213178 no 2237 0.333485268496449 3276 1251267
SGTC_1947 st076332 61.6 µM -0.430539775568871 0.338218586079125 no 2238 0.333401519671389 3280 24208416
SGTC_2558 carylophyllene oxide 100 µM -0.431099943166303 0.338012731891154 no 2239 0.333197850982279 3240 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.433518824319049 0.337124381780157 no 2240 0.332318946745949 3248 279621
SGTC_2240 6690706 185.951 µM -0.434333565872995 0.336825366611628 no 2241 0.332023116314284 3050 805876
SGTC_1844 rapamycin 4 nM -0.434512770812998 0.336759611122008 no 2242 0.331958061527514 3151 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2714 st079313 56.9 µM -0.43515057005776 0.336525624576301 no 2243 0.331726569430983 3172 2939799
SGTC_1659 st012954 42.1 µM -0.435924523729424 0.336241772665048 no 2244 0.331445745754864 3263 24207262
SGTC_653 0203-0016 55.2 µM -0.439371153897297 0.334978836650761 no 2245 0.330196312263113 3220 295302
SGTC_2137 5261020 140 µM -0.43950997517837 0.334928007831593 no 2246 0.330146027866653 3161 763655
SGTC_1792 st045773 43.6 µM -0.440479070019291 0.334573262165838 no 2247 0.329795083985675 3142 2919270
SGTC_3333 9141820 12.094 µM -0.440718200415908 0.33448574908372 no 2248 0.329708509350016 3158 1939433
SGTC_3142 9086498 49.47 µM -0.440853856500795 0.334436107857173 no 2249 0.329659400552212 3240 25236367
SGTC_1656 st012921 11 µM -0.441677281940589 0.334134850311585 no 2250 0.329361375724458 3257 6732821
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.442829210883362 0.333713586113395 no 2251 0.32894463652171 3330 551469
SGTC_68 0986-0284 82.829 µM -0.44439094793594 0.33314278841352 no 2252 0.328379978424722 3293 423278 YIL048W NEO1
SGTC_397 arbidol 50 µM -0.445104021232075 0.332882296347549 no 2253 0.328122291468038 3316 131410 A RNA synthesis inhibitor.
SGTC_835 0312-0010 67.2 µM -0.445853548664221 0.332608574183044 no 2254 0.327851519047467 3151 1626196
SGTC_2306 7482397 179.52 µM -0.446341136050556 0.332430558574817 no 2255 0.327675423000458 3321 891448
SGTC_196 k015-0023 18.111 µM -0.447518795898192 0.332000757040897 no 2256 0.327250259929504 3185 5211998
SGTC_1546 5-methoxyflavanone 78.7 µM -0.447754701863828 0.331914686785192 no 2257 0.327165119210069 3262 147795
SGTC_283 0987-0079 11.7 µM -0.450015054090471 0.331090447813418 no 2258 0.326349792900793 3295 411556
SGTC_495 decylubiquinone 155 µM -0.450313086110119 0.330981831177749 no 2259 0.326242352256598 3250 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2860 9025725 38.96 µM -0.451148552589535 0.330677424447892 no 2260 0.325941243193587 3139 40546248
SGTC_2242 6630449 61.2675 µM -0.452561578370306 0.330162835740325 no 2261 0.325432235297984 3304 691249 YDR170C SEC7
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.452575318579758 0.33015783347398 no 2262 0.325427287320534 3253 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2888 9058547 12.99 µM -0.452624139836501 0.330140059832612 no 2263 0.325409706579978 3164 16476514
SGTC_741 4582-0002 126 µM -0.453588067899025 0.329789215175305 no 2264 0.325062671616825 3182 2912688
SGTC_1734 st037168 69.4 µM -0.455378682862896 0.329137875584661 no 2265 0.324418414312869 3268 708907
SGTC_1706 st031321 9.9705 µM -0.456293014880203 0.328805485356263 no 2266 0.324089643121589 3305 6103185
SGTC_1362 1611-0397 101 µM -0.456460355814188 0.328744665984099 no 2267 0.324029486298015 3213 27816
SGTC_1014 4130-3005 69.3 µM -0.45664197604522 0.328678661992707 no 2268 0.323964201458249 3176 743608
SGTC_604 1000-0114 314 µM -0.457559229970514 0.328345397444029 no 2269 0.323634569978946 3330 1572745
SGTC_203 k066-0004 30.888 µM -0.460052152416506 0.327440337981738 no 2270 0.322739393478928 3313 6795412
SGTC_1441 4106-0040 13 µM -0.460212240998761 0.327382252136235 no 2271 0.322681942735316 3261 2904180
SGTC_1285 0929-0069 65.5 µM -0.460271998052796 0.327360571217464 no 2272 0.322660498897873 3242 1206237
SGTC_1695 st026914 34.495 µM -0.460301672893193 0.327349804875589 no 2273 0.322649850291321 3197 3289191
SGTC_1192 1488-0095 21.4 µM -0.461136574707635 0.327046952671559 no 2274 0.322350311323451 3291 915875
SGTC_101 0490-5701 117.494 µM -0.463542569303189 0.32617483982025 no 2275 0.32148775453577 3275 4661669
SGTC_111 0083-0039 52.457 µM -0.463965559662502 0.326021614426703 no 2276 0.32133621039627 3184 759313
SGTC_114 0364-0001 490.298 µM -0.464286267774197 0.325905459660432 no 2277 0.321221330588541 3291 4003655
SGTC_685 1278-0033 54.9 µM -0.466198577243505 0.325213206256226 no 2278 0.320536683827187 3348 3590572
SGTC_588 3970-1144 52.9 µM -0.46663121406631 0.325056675847442 no 2279 0.320381875359125 3292 1888707
SGTC_382 3229-0966 23.2 µM -0.46757502491374 0.324715306999377 no 2280 0.320044264290552 3370 5722370
SGTC_1941 st076221 61.8 µM -0.469757981857495 0.323926313133016 no 2281 0.31926396870863 3309 2828568
SGTC_2945 9067681 61.76 µM -0.469877490489538 0.323883141493784 no 2282 0.319221273542128 3339 16456930
SGTC_3080 9117754 49.47 µM -0.472009548256411 0.323113349464961 no 2283 0.318459986634897 3417 9550191
SGTC_1035 k081-0041 55.2 µM -0.473634491505086 0.322527162174924 no 2284 0.317880287509057 3371 731709
SGTC_2673 kobusone 100 µM -0.47402377121615 0.322386797559642 no 2285 0.317741477997077 3302 6710676 An epoxy ketone and protein crosslinker.
SGTC_3279 9140807 49.47 µM -0.474870491005915 0.322081578834722 no 2286 0.317439642783897 3289 45595718
SGTC_2546 rhodinyl acetate 100 µM -0.474960147174297 0.322049267321782 no 2287 0.317407689620422 3348 6708682
SGTC_3203 9113543 49.47 µM -0.475323707378975 0.321918256324235 no 2288 0.317278131907015 3331 17018012
SGTC_479 n-linoleoylglycine 10 µM -0.477183443324381 0.321248436303503 no 2289 0.316615749917374 3250 6433346 An anti-infammatory.
SGTC_2733 amorolfine 100 µM -0.47721365611523 0.321237559370751 no 2290 0.316604993875714 3295 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1302 1159-0335 255 µM -0.478092539573429 0.320921218922433 no 2291 0.316292170885099 3249 649284
SGTC_3042 9091578 49.47 µM -0.478493485075424 0.320776947968668 no 2292 0.316149505079463 3329 25236497
SGTC_624 k048-0052 28 µM -0.480512721943324 0.320050784062464 no 2293 0.315431429624735 3258 6835531
SGTC_2591 skatole 100 µM -0.481747649685979 0.319607014976695 no 2294 0.314992611062625 3334 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_51 1013-0126 23.419 µM -0.482030749247451 0.319505320005851 no 2295 0.31489205137006 3490 1627850
SGTC_2652 actinonin 100 µM -0.482228507555061 0.319434289355675 no 2296 0.314821813853467 3230 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3112 9123419 49.47 µM -0.482447103041129 0.319355782135694 no 2297 0.314744183421696 3332 17015854
SGTC_706 4262-0057 46.9 µM -0.482955135327555 0.319173356759223 no 2298 0.314563796109286 3253 883298
SGTC_2923 7992654 58.14 µM -0.483260863680324 0.319063596230715 no 2299 0.314455262296192 3276 2985126
SGTC_389 tpck 16.7 µM -0.483378960166501 0.319021202274207 no 2300 0.314413342240542 3300 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1422 4031-0024 15.5 µM -0.483751614647544 0.318887443301036 no 2301 0.314281078834462 3290 782427
SGTC_1369 1866-0067 208 µM -0.485706157961993 0.318186274648603 no 2302 0.313587758493542 3381 3531355
SGTC_899 1083-0020 478 µM -0.486159119657072 0.318023872973953 no 2303 0.313427176647125 3390 767123
SGTC_724 3910-0327 137 µM -0.486243792630625 0.317993518806711 no 2304 0.313397162705187 3325 2885483
SGTC_1889 st059080 5.18 µM -0.486870401336118 0.317768925695209 no 2305 0.313175087780918 3391 176925 Isolated from Daphnopsis sellowiana.
SGTC_281 1672-3440 14.9 µM -0.487414510634755 0.317573956919819 no 2306 0.312982306224771 3338 6833000
SGTC_1489 4065-0444 182 µM -0.488178658202098 0.317300228021464 no 2307 0.31271164996115 3348 2877968
SGTC_1253 0550-0034 176 µM -0.488868954360252 0.317053039662524 no 2308 0.312467238183243 3348 5969915
SGTC_1877 wortmannin 25 µM -0.489086993164923 0.316974979037517 no 2309 0.312390054754075 3393 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2743 auranofin 4.32 µM -0.489899227933738 0.316684260521011 no 2310 0.312102604701266 3260 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2165 5727197 32.143 µM -0.490053274945218 0.316629136124825 no 2311 0.31204810032877 3538 1361712
SGTC_1612 st002233 45.4 µM -0.490397908682034 0.316505826658234 no 2312 0.311926178130978 3365 1035021
SGTC_1145 3546-0597 10.2 µM -0.492505405054125 0.315752211503097 no 2313 0.311181050940444 3302 875334
SGTC_470 aa-861 153 µM -0.492681229598774 0.315689373324898 no 2314 0.311118921250721 3294 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2566 crystal violet carbinol 226 nM -0.492896179264289 0.315612559403406 no 2315 0.311042973546691 3353 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2688 kanamycin b 96.69 µM -0.493328900868712 0.315457947160018 no 2316 0.310890105356567 3447 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1640 st009078 66.4 µM -0.49419755627883 0.315147672480671 no 2317 0.310583332715436 3352 690618
SGTC_2635 hydroquinidine 100 µM -0.495223795194003 0.314781278598972 no 2318 0.310221077866498 3285 442912 An experimental heart treatment.
SGTC_629 3448-6466 76.7 µM -0.495903206819192 0.314538811290648 no 2319 0.309981351765192 3340 573744
SGTC_1131 3454-3128 32.3 µM -0.497277319032919 0.314048664870432 no 2320 0.309496751865335 3377 710982
SGTC_2152 5568786 200 µM -0.497468415318491 0.313980526690155 no 2321 0.309429385288982 3322 5399883
SGTC_526 4469-0568 170 µM -0.498968715220337 0.3134457932737 no 2322 0.308900711900254 3284 2901964
SGTC_2951 9072950 58.06 µM -0.50298386505581 0.312016652878491 no 2323 0.307487808116712 3382 16488155
SGTC_2274 7947094 46.08 µM -0.502994343242748 0.312012926990872 no 2324 0.307484124636153 3373 2971028
SGTC_1401 3807-4679 7.6 µM -0.503757968178909 0.311741445103262 no 2325 0.307215733757878 3346 3291456
SGTC_2197 6588183 93.1375 µM -0.504262192531573 0.311562240667312 no 2326 0.307038570850218 3311 884136
SGTC_3246 9135460 32.98 µM -0.504283838040296 0.311554548719101 no 2327 0.3070309665507 3334 41446951
SGTC_1468 k284-1086 134 µM -0.504778856293875 0.311378661479057 no 2328 0.306857083985824 3325 15996457
SGTC_959 1222-0044 107 µM -0.506703487809142 0.310695221022459 no 2329 0.306181441483707 3383 6083612
SGTC_2618 avocadyne 43.43 µM -0.508439737304584 0.310079235274103 no 2330 0.305572495537141 3315 3015189
SGTC_224 benfluorex 43.875 µM -0.509056442090267 0.30986056914843 no 2331 0.30535633105965 3394 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1450 4112-4260 37.6 µM -0.509332388316221 0.309762748172438 no 2332 0.305259629647918 3405 1633175
SGTC_1415 3966-0071 78.1 µM -0.510549731895032 0.309331369387389 no 2333 0.304833191280765 3359 2893185
SGTC_2702 st077768 96.8 µM -0.513206942868417 0.308390671082742 no 2334 0.303903284933693 3349 6484119
SGTC_3115 9123671 49.47 µM -0.514554563928252 0.307914069940346 no 2335 0.303432161166044 3437 3286988
SGTC_3280 9140961 49.47 µM -0.514755645075105 0.30784298310786 no 2336 0.303361891861409 3266 4901226
SGTC_2887 9044784 58.44 µM -0.515383564291712 0.307621045583421 no 2337 0.303142507640031 3350 6465546
SGTC_1456 k015-0012 13 µM -0.51716493280106 0.306991805675106 no 2338 0.302520514543825 3464 2989616
SGTC_3257 9139206 32.98 µM -0.518582435850254 0.306491501159337 no 2339 0.302025979994518 3372 4910041
SGTC_796 1234-0020 70.7 µM -0.518594397618358 0.306487280812627 no 2340 0.302021808351088 3370 46495034
SGTC_1293 1000-1278 195 µM -0.519012848375828 0.306339659323707 no 2341 0.301875890750842 3442 678847
SGTC_679 0422-0091 41.4 µM -0.520845638780506 0.305693456178236 no 2342 0.301237153583344 3318 627384 YHR062C RPP1
SGTC_918 glabranin 770.725 nM -0.521851737595415 0.30533898391957 no 2343 0.300886781817062 3363 124049 Also referred to as licorice root.
SGTC_103 0844-0104 51.839 µM -0.522229652680126 0.305205882673838 no 2344 0.300755221195543 3430 5375804
SGTC_2091 4-phenylthiadiazole 200 µM -0.522798228808137 0.305005679362562 no 2345 0.300557336154279 3296 270010
SGTC_2084 5306078 60.6385 µM -0.523361322220853 0.304807464094641 no 2346 0.300361417260691 3293 679340
SGTC_2433 5607874 27.82 µM -0.523950597041395 0.304600094005361 no 2347 0.300156450804491 3345 2252428
SGTC_2231 micatex 6.853 µM -0.523961443099491 0.304596277786945 no 2348 0.300152678831456 3375 20737 An antifungal of unknown mechanism.
SGTC_2469 5655019 90.81 µM -0.525298504459944 0.304125991712445 no 2349 0.299687848445205 3439 2788239
SGTC_813 k007-0158 173 µM -0.526367271643573 0.303750305897205 no 2350 0.299316525402923 3359 6523916
SGTC_3145 9085516 49.47 µM -0.526446181859199 0.303722576122793 no 2351 0.299289117808582 3372 25236195
SGTC_3161 9100388 49.47 µM -0.526864046790337 0.303575753383983 no 2352 0.299144001303101 3381 25236368
SGTC_806 3966-4455 5.86 µM -0.52830316846431 0.303070340389562 no 2353 0.29864446642042 3315 714982
SGTC_546 peri-Naphthalide 147 µM -0.529523258682987 0.302642145343043 no 2354 0.298221257096138 3320 223824 A penicillin ester.
SGTC_2243 6634756 200 µM -0.529684326261761 0.302585638358134 no 2355 0.298165408443623 3493 885676
SGTC_525 k781-2675 26.7 µM -0.530009771535424 0.302471477539544 no 2356 0.298052577927729 3435 3651118 YDL195W SEC31
SGTC_1647 st011722 22.4 µM -0.530297532319001 0.302370551906549 no 2357 0.297952828677484 3439 2854783
SGTC_2824 7998404 51.95 µM -0.531091531360409 0.302092152943277 no 2358 0.29767767621342 3320 837851
SGTC_3058 9093861 49.47 µM -0.531907625468242 0.301806126813359 no 2359 0.297394987815812 3457 17217477
SGTC_1609 st001574 46.4 µM -0.532115826054627 0.301733175790323 no 2360 0.297322888453486 3330 3960012
SGTC_1310 1188-0297 994 nM -0.532701552260695 0.301527986792597 no 2361 0.297120095726992 3361 1588352
SGTC_2962 9082311 13.18 µM -0.533407269433392 0.301280846520707 no 2362 0.296875843233055 3297 16459453
SGTC_714 4296-0578 26.1 µM -0.533452546687296 0.301264993661656 no 2363 0.296860175670146 3352 1589775
SGTC_890 0929-0006 47.2 µM -0.53518846613772 0.300657482254466 no 2364 0.296259770524602 3338 1378169
SGTC_2112 5488546 200 µM -0.535495520144552 0.300550081617233 no 2365 0.296153627275403 3329 600757
SGTC_9 0092-0002 10.449 µM -0.53554908682139 0.300531346964345 no 2366 0.296135111991056 3422 759368
SGTC_1635 st007035 42.4 µM -0.535688924833263 0.300482441868398 no 2367 0.296086779583422 3416 3716403
SGTC_2596 sinensetin 100 µM -0.535773447953389 0.300452883613818 no 2368 0.296057567494656 3320 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2853 9015042 58.44 µM -0.53704934007998 0.300006855947834 no 2369 0.295616766397561 3290 6457456
SGTC_332 4112-0506 40.9 µM -0.537266142385144 0.299931095765774 no 2370 0.295541894535381 3383 2790355
SGTC_615 k087-0205 167 µM -0.5377917420176 0.299747464278947 no 2371 0.295360416878301 3348 9642773
SGTC_245 methotrexate 289.6 µM -0.53967485917524 0.299089968220326 no 2372 0.294710640465981 3392 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2611 pyromycin 23.93 µM -0.540180461849175 0.298913547072746 no 2373 0.294536292753736 3332 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1871 st057448 67.3 µM -0.540305411542931 0.298869955363788 no 2374 0.294493213503103 3533 691747
SGTC_1813 st051246 8.6015 µM -0.540543133519077 0.298787028304924 no 2375 0.294411261471853 3391 5291959
SGTC_2969 9091408 28.7 µM -0.541441783220672 0.298473637399294 no 2376 0.294101557061338 3296 4286311
SGTC_2480 5767542 37.17 µM -0.541719827732781 0.298376703757428 no 2377 0.29400576423539 3377 2867358
SGTC_1275 0867-0008 21.1 µM -0.542398938929271 0.298140007962246 no 2378 0.29377185523677 3313 3422836
SGTC_3012 9080433 71.4286 µM -0.54271766840567 0.298028948252158 no 2379 0.293662103660525 3455 17688859
SGTC_331 k048-0133 24.5 µM -0.54286719057759 0.297976854488382 no 2380 0.293610623611019 3380 6813582
SGTC_329 k048-0121 21.3 µM -0.543571548199666 0.29773151101325 no 2381 0.293368171545309 3422 6832902
SGTC_993 3909-8757 62.7 µM -0.544318746909199 0.297471345815684 no 2382 0.293111074287468 3325 4288324 YLR208W SEC13
SGTC_1518 st038567 90.8 µM -0.544753867463623 0.297319890153685 no 2383 0.292961405511003 3432 77966
SGTC_673 1082-0474 110 µM -0.545993600632271 0.296888560286539 no 2384 0.292535168048033 3384 3098046
SGTC_3338 9144300 39.5675 µM -0.546616216410845 0.296672046917471 no 2385 0.292321212873208 3366 4901274
SGTC_2045 5106652 78.05 µM -0.548109215134908 0.296153154478837 no 2386 0.291808456732267 3427 673349
SGTC_621 3584-0052 32.1 µM -0.548867376823361 0.295889814526022 no 2387 0.291548233872496 3466 2273927
SGTC_1246 0422-0085 105 µM -0.550071678903332 0.295471733353153 no 2388 0.291135105433479 3477 264295
SGTC_1526 st051518 75 µM -0.55044870817248 0.295340901096003 no 2389 0.291005824069693 3334 673993
SGTC_2987 9018338 71.43 µM -0.550892891161218 0.295186800156222 no 2390 0.290853550468505 3497 5055682
SGTC_1442 4112-3290 3 µM -0.552250990835491 0.294715862779394 no 2391 0.290388201630523 3418 704353
SGTC_3121 9125696 49.47 µM -0.554614504511974 0.293897113284415 no 2392 0.289579182924669 3459 1235365
SGTC_715 0868-0130 184 µM -0.555473762457349 0.293599716986766 no 2393 0.289285325819304 3504 2876258
SGTC_1218 1348-1416 30.7 µM -0.555920103069492 0.293445289805609 no 2394 0.289132737391047 3428 6787668
SGTC_3290 9121031 71.43 µM -0.556527945161551 0.293235046058928 no 2395 0.288924998075115 3374 17014854
SGTC_360 0957-0399 1.01 µM -0.556710524621637 0.29317190811731 no 2396 0.288862612476612 3456 6752301 YPR165W RHO1
SGTC_1629 st005085 44.9 µM -0.557209853825954 0.292999266907643 no 2397 0.28869202900615 3359 24207091
SGTC_1416 3966-0321 25.3 µM -0.557981369892781 0.292732610889292 no 2398 0.288428552945205 3420 582530 YLR208W SEC13
SGTC_2943 9068529 45.32 µM -0.558093072361892 0.292694012952464 no 2399 0.288390415465915 3484 3270634
SGTC_3136 9095672 49.47 µM -0.560527863270068 0.291853277431951 no 2400 0.287559719917619 3364 17217380
SGTC_1874 staurosporine 7.6 µM -0.561140070605086 0.291642058803624 no 2401 0.287351026746042 3467 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_562 3772-2733 112 µM -0.561714697797292 0.29144387061665 no 2402 0.287155209349898 3481 2876874 YIL048W NEO1
SGTC_2325 6158266 200 µM -0.561753903269922 0.291430350988871 no 2403 0.287141851488243 3421 3623240
SGTC_1321 1326-2144 215 µM -0.563278785189765 0.290904737359061 no 2404 0.286622530930107 3444 3513030
SGTC_1279 0874-0590 65.2 µM -0.566015397414762 0.289962563426511 no 2405 0.285691656766491 3423 3523074
SGTC_204 PMA1.184 62.41 µM -0.566261853037082 0.289877782785308 no 2406 0.285607894138635 3444 2252213 YGL008C PMA1
SGTC_440 fluspirilene 35.1 µM -0.567263736849282 0.28953325488685 no 2407 0.285267505260045 3556 3396 An atypical antipsychotic.
SGTC_38 0929-0051 58.268 µM -0.567729673176447 0.289373094191769 no 2408 0.285109269797434 3433 1379719
SGTC_1658 st012944 20 µM -0.568162177171373 0.289224462771332 no 2409 0.28496242565956 3451 24207260
SGTC_2044 5102272 200 µM -0.569270660679661 0.288843692710895 no 2410 0.284586237139445 3473 592666
SGTC_1016 4226-1401 38 µM -0.569628858850203 0.288720700170766 no 2411 0.284464725345086 3465 2901613
SGTC_2521 angolensin 13.4 µM -0.573107408897979 0.287527574104647 no 2412 0.283285985536436 3503 821428 A flavenoid.
SGTC_2627 acetyl isogambogic acid 100 µM -0.573835212330918 0.287278236212739 no 2413 0.283039659063466 3436 6857789 A caspase activator and apoptosis inducer.
SGTC_1906 st060206 94.7 µM -0.575460207494504 0.286721899322439 no 2414 0.282490047645163 3477 5133468
SGTC_866 0495-0101 262 µM -0.575633230395873 0.286662692926508 no 2415 0.282431557492079 3372 635694
SGTC_195 4234-0266 16.654 µM -0.575752360051731 0.286621931533782 no 2416 0.282391289262337 3415 2303354
SGTC_1463 k081-0032 34.1 µM -0.578352874632705 0.285732825366717 no 2417 0.281512951655784 3390 977755
SGTC_948 3448-0295 75.3 µM -0.579898683547131 0.285204941570391 no 2418 0.280991471778149 3498 678569
SGTC_1687 st020778 55.3625 µM -0.580424804037081 0.285025380873846 no 2419 0.280814091145687 3479 4259299
SGTC_444 curcumin 90.4 µM -0.58090421066481 0.284861810195084 no 2420 0.280652507171368 3473 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1061 3448-9325 110 µM -0.581747949751836 0.284574040272429 no 2421 0.28036823425507 3499 723482
SGTC_100 0086-0128 49.5915 µM -0.582156867008145 0.284434622846069 no 2422 0.280230511865722 3462 93297
SGTC_2072 5231554 129 µM -0.582399820744146 0.284351804956798 no 2423 0.280148701130807 3558 789545
SGTC_2177 5811945 192 µM -0.582729095420272 0.284239580445811 no 2424 0.280037841692844 3507 5343475
SGTC_2425 5628681 7.85 µM -0.584194033749932 0.283740552030472 no 2425 0.279544887559494 3472 5714958
SGTC_3259 9138485 49.47 µM -0.584769581868613 0.28354460753622 no 2426 0.279351330025321 3645 17646153
SGTC_1010 4112-3296 15.2 µM -0.585281226527246 0.283370473338495 no 2427 0.279179317988509 3546 704384
SGTC_3047 9092122 49.47 µM -0.586117554225386 0.283085946300345 no 2428 0.27889826026235 3440 17173831
SGTC_2135 5326629 150.42 µM -0.586496473283806 0.282957079398345 no 2429 0.278770965403102 3444 5020077
SGTC_3275 9138069 49.47 µM -0.586892302261459 0.282822491673506 no 2430 0.278638019998325 3503 17617007
SGTC_4 0960-0234 25.671 µM -0.58787469311966 0.282488597128663 no 2431 0.278308201992263 3499 6821112
SGTC_1631 benzylvanillin 81.9 µM -0.589089603448355 0.282075936315501 no 2432 0.277900583627298 3501 75506
SGTC_1325 1431-0015 227 µM -0.589283286541516 0.282010176054933 no 2433 0.277835627348138 3418 1103340
SGTC_2988 9073640 71.4286 µM -0.590261029547008 0.28167832058435 no 2434 0.277507830942367 3562 9102229
SGTC_3008 9078912 71.4286 µM -0.590299428078148 0.281665291593349 no 2435 0.277494961376359 3492 16648731
SGTC_2982 9019404 25.97 µM -0.590449483899309 0.281614378996453 no 2436 0.277444671799659 3395 22333232
SGTC_2883 9059145 45.46 µM -0.591128884837029 0.281383919892133 no 2437 0.277217033728603 3444 16476510
SGTC_2553 4-methylesculetin 85.09 µM -0.591879471920817 0.28112941965784 no 2438 0.27696565051212 3479 5319502
SGTC_2665 lovastatin 100 µM -0.593287589145374 0.280652272001221 no 2439 0.276494351573364 3506 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.594186746459904 0.28034779308779 no 2440 0.276193608134024 3539 7104
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.594193209213809 0.280345605204172 no 2441 0.276191447101495 3430 6708514
SGTC_419 nsc-638432 893 µM -0.594532191649221 0.280230858579249 no 2442 0.276078108904015 3454 368090
SGTC_845 0330-0138 4.51 µM -0.59516577505909 0.280016449618335 no 2443 0.275866332619509 3484 9039800
SGTC_2880 9042983 58.44 µM -0.595247156006111 0.279988915513537 no 2444 0.275839136690921 3521 6464714
SGTC_2132 5317594 122.667 µM -0.595316147644932 0.279965574185955 no 2445 0.275816082059815 3469 794577
SGTC_2610 ononetin 44.17 µM -0.595648740016555 0.279853064405666 no 2446 0.275704954422739 3477 259632
SGTC_25 0118-0223 35.662 µM -0.595781010639517 0.279808325823113 no 2447 0.275660765534606 3544 5333628
SGTC_930 2810-3379 265 µM -0.597233853823654 0.279317151575035 no 2448 0.275175629864519 3575 1015764
SGTC_696 1560-0013 611 µM -0.597688487595666 0.27916353602412 no 2449 0.275023904248142 3581 1650269
SGTC_2062 5245942 200 µM -0.60132293941601 0.277936974995389 no 2450 0.273812456830535 3581 1376160
SGTC_3043 9092303 49.47 µM -0.60137821557656 0.277918340626055 no 2451 0.273794052390704 3466 25236084
SGTC_1215 3852-0577 11.2 µM -0.602491829007334 0.277543055858662 no 2452 0.27342340028637 3562 2884876
SGTC_3175 9106517 49.47 µM -0.604516980078299 0.276861220636191 no 2453 0.27274999176917 3499 41468073
SGTC_2867 9039098 71.43 µM -0.604763822820245 0.276778168847367 no 2454 0.27266796727441 3509 6463460
SGTC_2350 9023895 38.85 µM -0.607155390447276 0.275974143445167 no 2455 0.271873896864844 3523 2997209
SGTC_1136 pergolide 1.05886 µM -0.607454066419613 0.275873811668144 no 2456 0.271774808578988 3493 47811 A dopamine receptor agonist.
SGTC_3165 9101544 49.47 µM -0.608322179855037 0.275582295198118 no 2457 0.271486906662619 3530 5002184
SGTC_3066 9117245 49.47 µM -0.60842751191638 0.275546934516756 no 2458 0.271451984581047 3515 17176980
SGTC_2934 9036370 36.88 µM -0.60867013823597 0.275465491720216 no 2459 0.271371552098266 3494 6462800
SGTC_2195 6536160 144.242 µM -0.61062556664121 0.274809542314161 no 2460 0.270723746469191 3416 3834386
SGTC_3123 9126162 49.47 µM -0.610803166531959 0.274750004508248 no 2461 0.270664948420866 3558 25239884
SGTC_1692 fluoroquinolonic acid 71 µM -0.611754030657462 0.274431349220037 no 2462 0.27035025406857 3548 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.61286978001934 0.274057670033353 no 2463 0.269981223297407 3460 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1070 indatraline 8.81 µM -0.614149025141343 0.273629543570413 no 2464 0.269558427224669 3523 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1923 st058458 19.1 µM -0.614796848430672 0.273412862085666 no 2465 0.269344445434571 3601 3534982
SGTC_3147 9097027 49.47 µM -0.616132767535188 0.272966297323042 no 2466 0.268903448573609 3514 25236841
SGTC_70 0141-0289 43.283 µM -0.617842846810712 0.272395188311585 no 2467 0.268339468216761 3541 352408
SGTC_2973 9094665 17.96 µM -0.618661968242995 0.272121839666908 no 2468 0.268069534679164 3579 25237061 YIL048W NEO1
SGTC_2443 5493264 126.67 µM -0.618943513753421 0.272027916741986 no 2469 0.267976785657413 3546 5340055
SGTC_635 k038-0028 24.7 µM -0.619748692006435 0.271759400162034 no 2470 0.267711626473994 3527 4035102
SGTC_1008 4106-0037 6 µM -0.620752399364047 0.271424861497755 no 2471 0.267381273449936 3534 2905394
SGTC_1534 6-azauridine 81.6 µM -0.62084276625073 0.271394752014939 no 2472 0.267351540836176 3550 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2653 dihydrofissinolide 100 µM -0.620974119411537 0.271350989219842 no 2473 0.267308325847334 3563 6857746
SGTC_1147 3809-1045 12.3 µM -0.621049841773764 0.271325762477726 no 2474 0.267283414907709 3501 325925
SGTC_1786 berberine 21.6 µM -0.621492829044363 0.271178205644702 no 2475 0.267137705619393 3542 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2545 solidagenone 89.61 µM -0.621525341424018 0.271167377510691 no 2476 0.267127013086637 3402 6708572 An anti ulcer agent
SGTC_669 0108-0021 26.2 µM -0.624000556214894 0.270343649415535 no 2477 0.266313609892192 3686 17201
SGTC_1156 4092-0367 4.88 µM -0.626338949046614 0.269566605099501 no 2478 0.265546322163255 3522 1357585
SGTC_755 1995-0008 37.3 µM -0.629921256141749 0.268378384513062 no 2479 0.264373052467385 3575 689533
SGTC_3020 9089140 49.47 µM -0.632353226020005 0.267573224737956 no 2480 0.263578045349915 3577 17217859
SGTC_2511 berberine 10.47 µM -0.632542544764776 0.267510597524982 no 2481 0.263516208567207 3565 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1085 doxorubicin 7.67 µM -0.633277441763473 0.2672675614314 no 2482 0.263276240880613 3589 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2785 7756463 72.73 µM -0.633353270587802 0.267242490598515 no 2483 0.263251486665428 3540 2201551
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.634231617186797 0.266952174610577 no 2484 0.262964838289967 3538 688664
SGTC_1563 conessine 56.1 µM -0.634392272400677 0.266899091196894 no 2485 0.262912425733784 3628 441082 An anti-amoebic, histamine inhibitor.
SGTC_1856 st057054 55.7 µM -0.634878181206183 0.266738570524169 no 2486 0.262753934150647 3648 1266018
SGTC_2805 7950783 58.44 µM -0.635025891738061 0.266689783810442 no 2487 0.262705764271353 3554 1178958 YDL195W SEC31
SGTC_3154 9100113 49.47 µM -0.636865285019042 0.266082636112952 no 2488 0.262106298399731 3530 25237525
SGTC_766 1391-0721 126 µM -0.637468036718835 0.265883831969316 no 2489 0.261910011744384 3585 1020919 YIL115C NUP159
SGTC_3094 9117742 49.47 µM -0.638985149972203 0.265383779524194 no 2490 0.261416296239408 3536 17149698
SGTC_2221 6807166 181.081 µM -0.639158850162794 0.265326557043408 no 2491 0.261359799341864 3530 674925
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.639415380033279 0.265242059233715 no 2492 0.261276373128461 3560 6312947
SGTC_2396 5342950 42.78 µM -0.639436281006074 0.265235175310251 no 2493 0.261269576514961 3562 1886677
SGTC_775 4577-0580 57.3 µM -0.640007134208309 0.265047194750492 no 2494 0.26108398063625 3647 2006902
SGTC_1743 st037606 46.3785 µM -0.640754000857226 0.264801355638189 no 2495 0.26084126161792 3592 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3053 9095903 49.47 µM -0.643022484404311 0.264055371570749 no 2496 0.260104755215416 3629 17174018
SGTC_1723 st034307 2.5525 µM -0.643389573871458 0.263934756028942 no 2497 0.259985673485477 3590 867466
SGTC_2764 methyldopa 94.69 µM -0.64501343157196 0.263401537965558 no 2498 0.259459240780022 3623 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1187 1391-0724 117 µM -0.64624603071008 0.262997163004747 no 2499 0.259060016687629 3607 6997986
SGTC_3255 9139072 49.47 µM -0.646277350301125 0.262986892219414 no 2500 0.259049876787041 3605 17646060
SGTC_1311 1190-0148 100 µM -0.647383716367941 0.262624207822008 no 2501 0.258691816032408 3635 1961333
SGTC_302 1094-0063 18.9 µM -0.648233790975126 0.262345713822475 no 2502 0.258416874771695 3544 5440289
SGTC_2380 9035439 200 µM -0.648585375293724 0.262230575074948 no 2503 0.258303205451319 3662 6462575
SGTC_2897 9048598 12.99 µM -0.648806802393155 0.262158074211032 no 2504 0.258231630041917 3565 6467404
SGTC_2166 5933061 31.504 µM -0.649324609830049 0.261988570990398 no 2505 0.258064291033615 3802 2877375
SGTC_277 nystatin 15.5 µM -0.652875121417862 0.260827833552863 no 2506 0.256918394477496 3584 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_603 3794-0023 45.9 µM -0.653703178358587 0.26055750514863 no 2507 0.256651527582162 3594 3802260
SGTC_1807 st050092 58.9 µM -0.657055194636496 0.259464677822158 no 2508 0.25557271357151 3564 5008496
SGTC_551 k048-0028 34.9 µM -0.658040398815559 0.259143931422697 no 2509 0.255256086136304 3622 6836383
SGTC_1490 4089-0339 670 nM -0.658315659177511 0.259054353379689 no 2510 0.255167658926404 3569 742542
SGTC_1241 0364-0022 50.8 µM -0.660253423640577 0.258424199669144 no 2511 0.25454560699886 3603 4563895
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.660895063503493 0.258215715947211 no 2512 0.25433980604123 3625 6708784 An antioxidant flavonoid
SGTC_1578 josamycin 24.2 µM -0.66124558865185 0.258101859006319 no 2513 0.254227414696563 3548 5282165 A P450 substrate.
SGTC_743 1275-0778 158 µM -0.661904785718407 0.257887810349479 no 2514 0.254016122261724 3606 2849257 YMR203W TOM40
SGTC_2678 equilin 100 µM -0.663484634354103 0.257375190981799 no 2515 0.25351010863948 3638 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2855 9016525 58.44 µM -0.667131097565951 0.256194034120386 no 2516 0.252344198993298 3640 43811474
SGTC_1272 0839-0021 27 µM -0.66987973229581 0.255305572308276 no 2517 0.2514672304236 3624 5027250
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.670675737684895 0.255048574605878 no 2518 0.251213561164934 3596 17037758
SGTC_2367 9070478 135.38 µM -0.670775279831868 0.255016446025681 no 2519 0.251181848813039 3607 572802
SGTC_1263 0774-1208 64.8 µM -0.670887022574396 0.254980382060289 no 2520 0.251146252091666 3666 906585
SGTC_3107 9121808 49.47 µM -0.671614092111708 0.254745792089518 no 2521 0.2509147023026 3580 662681
SGTC_1290 0986-0249 10.2 µM -0.671642441886013 0.254736647286006 no 2522 0.250905676041113 3587 53329
SGTC_1443 4112-3303 14 µM -0.671943634827901 0.254639501914663 no 2523 0.250809790079656 3634 704433
SGTC_873 0591-4978 488 µM -0.672202413026494 0.254556052296753 no 2524 0.250727422516431 3688 3305145
SGTC_2569 tetrandrine 100 µM -0.673933437470842 0.253998208049564 no 2525 0.250176816313121 3598 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1002 4049-0206 172 µM -0.674343572505183 0.253866130966124 no 2526 0.250046454135495 3665 4662749
SGTC_3220 9131269 49.47 µM -0.675464333602614 0.253505392656071 no 2527 0.249690402042013 3670 17722206
SGTC_53 0973-0023 39.979 µM -0.675754718637352 0.253411970652214 no 2528 0.249598194207743 3618 674768
SGTC_1077 5-fluorocytosine 377 nM -0.676847720822452 0.253060494802156 no 2529 0.249251288413335 3626 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2799 7812892 81.82 µM -0.677342497360884 0.252901474266408 no 2530 0.249094336607186 3626 20205235
SGTC_1328 1441-0025 69.2 µM -0.679455786415148 0.252222858419913 no 2531 0.248424556490281 3587 4562601
SGTC_1516 st013856 110 µM -0.679485083702403 0.252213457277103 no 2532 0.248415277837541 3627 5281404 A mutagen and neurotoxin.
SGTC_1944 st076371 56.9 µM -0.682777543539873 0.251158125363977 no 2533 0.24737371090222 3638 24208455
SGTC_1853 st056710 91.2 µM -0.68350320445827 0.250925843832105 no 2534 0.247144463009056 3720 269167
SGTC_2066 5222451 176 µM -0.684079011283669 0.250741611008284 no 2535 0.246962637306179 3665 2281147
SGTC_3247 9135149 49.47 µM -0.68461812202775 0.250569184262212 no 2536 0.246792464233808 3623 8934436 YOR116C RPO31
SGTC_1969 st069479 40.1 µM -0.684742844885996 0.250529302415869 no 2537 0.246753103767238 3620 3895485
SGTC_107 0358-0022 2.6945 µM -0.685700339649915 0.250223242374743 no 2538 0.246451046271097 3641 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_257 daunorubicin 18.5 µM -0.685864553482787 0.250170771891063 no 2539 0.246399262224468 3687 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_447 ml7 120 µM -0.687411887816894 0.249676646028437 no 2540 0.245911604226668 3686 4216 Selective myosin light chain kinase inhibitor.
SGTC_216 k038-0035 28.382 µM -0.688111926345782 0.249453266093863 no 2541 0.245691150324975 3592 4444231 YPR107C YTH1
SGTC_3337 9144342 33.5465 µM -0.689017962803207 0.249164310679078 no 2542 0.245405981848089 3663 17682949
SGTC_3156 9099931 49.47 µM -0.69244885225025 0.248071738198009 no 2543 0.244327747940606 3683 18111053
SGTC_2149 5554786 194.827 µM -0.694686557754193 0.247360516633776 no 2544 0.243625876980878 3706 745063 YPR165W RHO1
SGTC_722 3534-0461 190 µM -0.696288056890439 0.246852173793344 no 2545 0.243124225536809 3649 658262
SGTC_530 4358-1714 28 µM -0.696906446617825 0.246656036214978 no 2546 0.242930671549343 3730 1564641
SGTC_985 1493-0307 8.71 µM -0.697733934035362 0.246393708760949 no 2547 0.242671801128737 3665 3278274
SGTC_330 1488-0319 80.1 µM -0.698912280393628 0.246020411329368 no 2548 0.242303426217754 3689 6846614
SGTC_951 1171-0579 82.7 µM -0.69945210022434 0.245849499036996 no 2549 0.242134768886629 3667 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2113 5491891 107.031 µM -0.700402575114861 0.245548724253569 no 2550 0.241837964273803 3682 789979
SGTC_1221 2958-7315 257 µM -0.700555078476598 0.245500483454485 no 2551 0.241790360463192 3684 4562705
SGTC_1139 k015-0024 46.9 µM -0.702163247102793 0.24499208778402 no 2552 0.24128868150695 3662 2766652
SGTC_1093 fluphenazine 7.97 µM -0.704043141874945 0.24439850922586 no 2553 0.240702953562425 3721 6602611 An atypical antipsychotic.
SGTC_3286 9117135 37.221 µM -0.704806309661797 0.244157759625323 no 2554 0.240465390700873 3663 3438150
SGTC_2690 usnic acid 100 µM -0.706186813336458 0.243722589768701 no 2555 0.24003598488868 3725 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1123 mangostin 811.285 nM -0.706538490007326 0.243611799299286 no 2556 0.239926662679288 3672 5281650 An antioxidant.
SGTC_379 3970-0972 5.9 µM -0.707704459529926 0.243244672703235 no 2557 0.239564403733276 3700 2898042 YBL034C STU1
SGTC_2316 5844804 197.44 µM -0.708303479016992 0.243056176939217 no 2558 0.239378408549567 3746 776813
SGTC_1326 1431-2094 10.8 µM -0.708583230277999 0.242968173604283 no 2559 0.239291572979893 3665 616278
SGTC_191 3914-0123 66.505 µM -0.708737108269402 0.242919774464167 no 2560 0.2392438161604 3625 3144412
SGTC_3085 9117376 49.47 µM -0.709303360725999 0.242741716386893 no 2561 0.239068121671382 3752 16480349
SGTC_1130 3454-2858 15.9 µM -0.70946976581197 0.242689403744104 no 2562 0.23901650359592 3705 715628 YIL048W NEO1
SGTC_1150 3909-7983 10.9 µM -0.709504628047328 0.242678444902485 no 2563 0.239005690266406 3691 23965914
SGTC_1213 1315-0166 115 µM -0.70967510744899 0.242624859060165 no 2564 0.23895281598462 3690 768401
SGTC_2129 girgensonine 121.053 µM -0.710643541921778 0.242320578043278 no 2565 0.238652576890897 3746 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3222 9128301 49.47 µM -0.710957562402803 0.242221957579884 no 2566 0.238555266968412 3735 4911358
SGTC_963 1269-2853 151 µM -0.711355797192423 0.242096920284577 no 2567 0.238431891621828 3689 3668223
SGTC_573 3702-0553 84.7 µM -0.713234252670723 0.241507597200713 no 2568 0.237850407039978 3674 1222756
SGTC_2126 5251174 33.877 µM -0.714120952041609 0.241229686165166 no 2569 0.237576195572578 3715 790722
SGTC_1699 st031318 29.054 µM -0.714670420698489 0.241057557897314 no 2570 0.237406359686433 3765 5340658
SGTC_2873 9040596 71.43 µM -0.716880294656912 0.240365960779024 no 2571 0.236723980874245 3676 6463863
SGTC_2394 5221648 200 µM -0.719569799058886 0.239525719926412 no 2572 0.235894956190228 3783 788586
SGTC_3054 9094397 49.47 µM -0.720992571218705 0.2390818743017 no 2573 0.235457042688567 3711 2598354
SGTC_1417 3966-0327 90.4 µM -0.722008333877908 0.238765273933979 no 2574 0.235144676871252 3767 651118
SGTC_1473 k844-0725 134 µM -0.723083566691793 0.238430387520403 no 2575 0.234814272389293 3782 54682906
SGTC_957 1187-1561 14.1 µM -0.726637810846326 0.237325233535747 no 2576 0.233723929598435 3700 1538454
SGTC_3159 9100096 49.47 µM -0.727622304298759 0.237019614140945 no 2577 0.233422411622865 3691 25236875
SGTC_1686 st019653 115.5 µM -0.727838033978755 0.236952673402095 no 2578 0.233356369549855 3709 97252
SGTC_2926 9010726 65.15 µM -0.729047840401743 0.236577464106523 no 2579 0.232986199488032 3731 2994293
SGTC_2087 5276107 200 µM -0.729325987706034 0.236491245760423 no 2580 0.232901139603496 3687 144405
SGTC_550 4123-0385 25.7 µM -0.729818605670503 0.236338589595928 no 2581 0.232750535050436 3742 5731123
SGTC_2484 5809818 12.04 µM -0.729912721675707 0.236309430393506 no 2582 0.23272176779885 3723 2870548
SGTC_2885 9057732 51.95 µM -0.730021876408765 0.236275614344513 no 2583 0.232688406324133 3732 6471414
SGTC_221 trifluoperazine 10.304 µM -0.732834251132711 0.235405262314937 no 2584 0.231829764119091 3727 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_809 3998-0021 90 µM -0.733291025928382 0.23526407039702 no 2585 0.231690473640346 3651 715485
SGTC_1440 4100-1550 40 µM -0.73459100136304 0.23486249594177 no 2586 0.231294309993536 3741 742806
SGTC_1108 betulinic acid 729.144 nM -0.735005849111306 0.234734425412873 no 2587 0.231167965951043 3741 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_776 4476-4378 112 µM -0.736406052965937 0.23430244398254 no 2588 0.230741811039802 3779 2892008
SGTC_2096 5468907 200 µM -0.736757991078401 0.234193935653228 no 2589 0.230634767007128 3764 759785
SGTC_1121 fusaric acid 630.51 nM -0.73694667186606 0.234135773710165 no 2590 0.230577390070601 3748 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3030 9087619 49.47 µM -0.737871483241596 0.2338508109716 no 2591 0.230296274694805 3741 25236973
SGTC_1840 st055363 71 µM -0.738155508269917 0.233763332744187 no 2592 0.230209977950896 3737 676033
SGTC_1172 0370-0043 85 µM -0.740917083832887 0.232913728056073 no 2593 0.229371858185657 3764 376585
SGTC_110 0850-0284 111.64 µM -0.742224971403693 0.232511952942777 no 2594 0.228975520648999 3581 3906265
SGTC_2145 5634607 200 µM -0.746592056214437 0.231173206747447 no 2595 0.227654922483119 3719 308662
SGTC_1624 st003710 6.25 µM -0.747511965179872 0.230891754622873 no 2596 0.227377291505736 3749 24207033
SGTC_1672 st016598 6.51 µM -0.747530267814827 0.23088615675477 no 2597 0.227371769657702 3780 4665860 YNL267W PIK1
SGTC_278 4092-0821 23.9 µM -0.751143415591091 0.229782559357377 no 2598 0.226283174814733 3757 877900
SGTC_1720 st037298 9.481 µM -0.753242987952407 0.229142626743481 no 2599 0.22565195570384 3781 597396
SGTC_1032 k061-1018 98.7 µM -0.753389522642978 0.229098001505405 no 2600 0.225607938481582 3883 4005393
SGTC_3339 9145883 14.936 µM -0.753634157165244 0.22902351210058 no 2601 0.225534464101863 3681 2030670
SGTC_77 0828-0286 12.516 µM -0.754838606032688 0.228656964524774 no 2602 0.225172913304161 3723 745345
SGTC_2379 9035213 200 µM -0.754968866349817 0.228617342406712 no 2603 0.225133831518104 3747 646551
SGTC_611 3453-1652 23.7 µM -0.756071925474203 0.228281972440718 no 2604 0.22480303662276 3738 1560575
SGTC_2479 5617353 43.85 µM -0.756273480395079 0.228220722331631 no 2605 0.224742622385574 3787 2731746
SGTC_747 3448-8087 38.7 µM -0.756410217631904 0.228179174795223 no 2606 0.224701641896592 3804 5168703
SGTC_409 arachidonic acid 100 µM -0.756437026045346 0.228171029571745 no 2607 0.22469360784553 3767 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_356 1634-0012 32.5 µM -0.756621421037244 0.228115009111098 no 2608 0.224638352041511 3739 735457
SGTC_3070 9117005 49.47 µM -0.758255896418345 0.227618782556201 no 2609 0.224148902232013 3789 8779016
SGTC_96 0929-0093 37.281 µM -0.758670235952912 0.227493085747277 no 2610 0.224024922993297 3740 6991579
SGTC_3353 9151644 39.2805 µM -0.758772758414424 0.227461989882922 no 2611 0.223994252096352 3817 4909158
SGTC_2074 5212007 75.395 µM -0.758969091800887 0.22740244711417 no 2612 0.223935523128717 3653 758611
SGTC_1278 0874-0585 172 µM -0.759453392125178 0.227255609071858 no 2613 0.223790692377642 3828 766306
SGTC_1185 1319-0113 81.3 µM -0.760660153067873 0.226889956226577 no 2614 0.223430040402774 3815 4672763
SGTC_3252 9135871 49.47 µM -0.760827206685218 0.226839364550264 no 2615 0.223380140911096 3782 17682838
SGTC_3056 9094900 49.47 µM -0.7608882763332 0.226820871383007 no 2616 0.223361900779517 3754 25236784
SGTC_2698 st077697 67.5 µM -0.761099951288527 0.226756778361139 no 2617 0.22329868478709 3760 3154499
SGTC_1254 0550-0035 264 µM -0.762244952654767 0.226410260797644 no 2618 0.222956910653418 3848 15121435
SGTC_3298 9116858 71.43 µM -0.762376560120459 0.226370450934204 no 2619 0.22291764593485 3801 2506942
SGTC_769 0302-0231 76 µM -0.763981133325984 0.225885402596003 no 2620 0.222439242907543 3750 571869 YER009W NTF2
SGTC_2826 7992541 19.48 µM -0.764410659615943 0.225755660373518 no 2621 0.222311279194782 3835 2985066
SGTC_1444 4112-3581 28 µM -0.766370506742679 0.225164206437935 no 2622 0.221727938276625 3801 2877249
SGTC_2854 9024559 71.43 µM -0.766991812668793 0.224976888574487 no 2623 0.22154319169534 3799 3163529
SGTC_2889 9059656 51.95 µM -0.768354733687997 0.224566290296511 no 2624 0.221138232709859 3872 3949838
SGTC_1065 prochlorperazine maleate 2.48 µM -0.76892374576316 0.224394993640429 no 2625 0.220969289946961 3824 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_476 mead acid 10 µM -0.76945292454591 0.224235755064396 no 2626 0.220812240225419 3803 5312531 An omega 9 fatty acid.
SGTC_984 1492-0255 2.91 µM -0.770495962699316 0.223922075721301 no 2627 0.220502874497905 3757 1585198
SGTC_1347 1493-0251 600 nM -0.773391243694543 0.223052667818037 no 2628 0.219645435266001 3826 3986378
SGTC_854 0422-0053 192 µM -0.773744175513034 0.222946819479132 no 2629 0.219541045373716 3826 3596728
SGTC_2117 5521686 200 µM -0.774126460845966 0.222832199968236 no 2630 0.21942800547972 3760 803312
SGTC_982 1491-0518 27.5 µM -0.776190660477797 0.22221387735175 no 2631 0.218818209865953 3747 3091256
SGTC_2999 9069765 71.4286 µM -0.776445973492793 0.222137467472332 no 2632 0.218742854381918 3819 2097066
SGTC_3052 9092717 49.47 µM -0.776450760469718 0.222136034972856 no 2633 0.218741441651182 3766 25237534
SGTC_3224 9130643 49.47 µM -0.777215485244919 0.221907259330963 no 2634 0.218515823808847 3813 17644395
SGTC_76 0433-0009 400.328 µM -0.778716716393689 0.221458541449438 no 2635 0.218073303384984 3883 2841569
SGTC_1915 st067105 30.6 µM -0.778806040549765 0.221431858826512 no 2636 0.218046989446466 3785 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1406 3909-7906 11.9 µM -0.778850300385694 0.221418638352563 no 2637 0.218033951651626 3816 X1406
SGTC_413 propylparaben 100 µM -0.780005362127974 0.221073779428194 no 2638 0.2176938594878 3761 7175 A pharmaceutical preservative.
SGTC_1331 1472-0049 76.2 µM -0.780329443522387 0.220977075897334 no 2639 0.217598493158059 3754 24051409
SGTC_23 0213-0011 39.996 µM -0.780922723966012 0.22080010807564 no 2640 0.217423973021552 3816 627608
SGTC_2742 clothiapine 36.27 µM -0.780980765902064 0.220782799282029 no 2641 0.217406903671895 3734 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2449 5812982 45.77 µM -0.781408687627482 0.220655211933078 no 2642 0.217281081552636 3767 776185
SGTC_895 0964-0006 13.7 µM -0.78203703536743 0.220467942965456 no 2643 0.217096404270014 3765 6738897
SGTC_1270 0831-1170 17.3 µM -0.782731529185304 0.220261066230833 no 2644 0.21689239159241 3802 6764716
SGTC_1033 k072-0102 21.3 µM -0.782786667250804 0.220244646401811 no 2645 0.216876199129437 3760 5965931
SGTC_1704 st028805 70.8 µM -0.782910800535304 0.220207682724444 no 2646 0.216839747314133 3827 2876101
SGTC_2537 larixol 68.93 µM -0.783078105010278 0.220157869413519 no 2647 0.216790623856857 3804 6708759
SGTC_1741 st038134 10.228 µM -0.783412279946075 0.220058391363745 no 2648 0.216692523641194 3852 1272587
SGTC_2260 7964312 200 µM -0.784756362719564 0.219658541888002 no 2649 0.216298214811915 3836 231951
SGTC_2723 salbutamol 83.58 µM -0.784781853790108 0.219650962615159 no 2650 0.216290740602077 3773 9884233 β2-adrenoceptor agonist
SGTC_1445 4239-0156 97.7 µM -0.785489334374179 0.219440666987458 no 2651 0.216083360636243 3910 4008346
SGTC_2094 5332512 191.667 µM -0.78741615734225 0.218868513853223 no 2652 0.215519145716633 3858 755774
SGTC_1437 4092-1038 11.6 µM -0.787980970671542 0.21870096031106 no 2653 0.215353918394801 3819 3977136
SGTC_1367 1812-0510 76.9 µM -0.788228627493561 0.218627515472357 no 2654 0.215281493442553 3848 1142582 YDR527W RBA50
SGTC_710 3448-4187 58 µM -0.789159578864349 0.218351560576295 no 2655 0.215009371767356 3810 3946412
SGTC_2619 obliquin 87.91 µM -0.793434001587629 0.217087104089989 no 2656 0.213762503607986 3788 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2374 9071832 200 µM -0.796757989465602 0.216106735594029 no 2657 0.21279579899093 3753 17381698
SGTC_214 4373-3496 70 µM -0.796995948071451 0.216036651181799 no 2658 0.212726692286729 3896 3779166
SGTC_46 0329-0187a 2.197 µM -0.79817311243735 0.215690142280652 no 2659 0.212385019112236 3894 46494817
SGTC_2998 9066762 71.4286 µM -0.798970202322804 0.215455694783702 no 2660 0.212153845137743 3842 4945196
SGTC_1377 2944-0135 198 µM -0.798988670137565 0.215450264610834 no 2661 0.212148490800825 3886 1894137
SGTC_348 k064-0012 10.7 µM -0.799097580566602 0.215418242812601 no 2662 0.212116916222893 3747 5066323
SGTC_2909 7941780 10.49 µM -0.800807632211839 0.214915816285503 no 2663 0.211621509945855 3788 1243215
SGTC_863 0466-0191 129 µM -0.801750664807417 0.214639037355964 no 2664 0.211348601011845 3874 765160 YPR165W RHO1
SGTC_2795 7780010 54.55 µM -0.802319652011775 0.214472140554007 no 2665 0.211184038713765 3846 953673
SGTC_407 eburnamonine 100 µM -0.806707075062 0.213187746742602 no 2666 0.209917633485485 3716 3195
SGTC_400 oxethazaine 37.5 µM -0.807012580814343 0.213098478994978 no 2667 0.209829617479673 3863 4621 A local anesthetic.
SGTC_924 2046-0044 21.3 µM -0.807416785027285 0.212980405406078 no 2668 0.209713199857149 3828 3623589
SGTC_2301 7769476 200 µM -0.807439978113013 0.21297363154619 no 2669 0.209706521010092 3891 977820
SGTC_2302 7771753 200 µM -0.807902547318433 0.212838558101924 no 2670 0.209573342393584 3860 2203047
SGTC_172 1112-0046 2.638 µM -0.808243327349553 0.212739079945049 no 2671 0.209475260014526 3810 2802135 YIL048W NEO1
SGTC_1988 st071872 53.4 µM -0.808345460655875 0.212709271182248 no 2672 0.209445869545539 3858 16414116
SGTC_2159 5658611 73.75 µM -0.808423928074779 0.212686371233501 no 2673 0.209423290956885 3810 793844
SGTC_3254 9136651 49.47 µM -0.808542526892745 0.212651762060761 no 2674 0.209389167486727 3833 16454030
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.808880723707174 0.212553088481684 no 2675 0.209291878846156 3658 88881 An O-methylated flavonoid and antioxidant.
SGTC_416 estradiol valerate 100 µM -0.812961212115842 0.211364659277178 no 2676 0.208120148586951 3890 13791 A steroid.
SGTC_2598 perillyl alcohol 100 µM -0.812982613357017 0.211358436511606 no 2677 0.208114013349875 3881 10819 An apoptosis inducer.
SGTC_2063 5246145 200 µM -0.813941405324952 0.211079761966999 no 2678 0.207839259567763 3899 711240
SGTC_1483 3453-0561 55.9 µM -0.814621478554549 0.210882228123227 no 2679 0.207644506037856 3869 4546991
SGTC_1376 2910-0861 41.3 µM -0.815438496892964 0.210645060645672 no 2680 0.207410677978156 3819 1112859
SGTC_2352 9027995 87.8 µM -0.816451162439688 0.210351317185048 no 2681 0.207121072447315 3823 2997347
SGTC_258 haloperidol 50.781 µM -0.817161908761159 0.210145295014218 no 2682 0.206917953739347 3886 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1034 k072-0165 12.7 µM -0.818585060463436 0.209733126221905 no 2683 0.206511596724462 3872 5835461
SGTC_882 0843-0131 351 µM -0.819225952793094 0.209547668300405 no 2684 0.206328755195244 3832 5425421
SGTC_2529 gangaleoidin 93.61 µM -0.81948295355774 0.20947332592873 no 2685 0.206255461861048 3882 4565183
SGTC_2120 5538279 151.968 µM -0.820819929912771 0.209086830432093 no 2686 0.20587442232436 3841 2058197
SGTC_2492 derrusnin 100 µM -0.823121592108865 0.208422446449706 no 2687 0.205219425580726 3773 1715307 Part of coumarin class of compounds.
SGTC_1349 flufenamic acid 69 µM -0.823984317014299 0.208173738621768 no 2688 0.204974234556572 3811 3371 A non-steroidal anti-inflammatory.
SGTC_2458 5808907 16.39 µM -0.824253704773157 0.208096114947992 no 2689 0.204897708811724 3969 2731747
SGTC_1142 3253-1408 9.78 µM -0.824541182194422 0.208013297611057 no 2690 0.204816063025059 3802 256655
SGTC_1817 st052116 64.4 µM -0.826616135055618 0.207416116392334 no 2691 0.204227334562044 3853 4361398
SGTC_1986 st071812 45 µM -0.826632573885134 0.207411389269766 no 2692 0.204222674383577 3797 11838594
SGTC_2103 5378138 10 µM -0.827572132564034 0.207141317190681 no 2693 0.203956427881737 3901 244142
SGTC_154 3389-1638 511.116 µM -0.827615651216642 0.207128812984883 no 2694 0.203944100840996 3864 5238686
SGTC_2305 7443522 69.23 µM -0.827674593472139 0.207111877830279 no 2695 0.203927405637093 3802 5415886
SGTC_3167 9103034 49.47 µM -0.829325826255672 0.206637782364878 no 2696 0.203460030343367 3900 5127859
SGTC_94 0334-0113 514.748 µM -0.829454028541455 0.206601000334764 no 2697 0.20342376991515 3893 6795178
SGTC_207 4185-0010 4.486 µM -0.830148041905756 0.206401950925078 no 2698 0.203227543769439 3921 3761753
SGTC_3120 9124077 49.47 µM -0.831861018434636 0.205911140141516 no 2699 0.20274369859847 3944 18774327 YGL155W CDC43
SGTC_1895 st058434 18.3 µM -0.833375054547451 0.205477907724939 no 2700 0.202316619462391 3905 5393175
SGTC_2280 7785178 200 µM -0.833544585998173 0.205429431028851 no 2701 0.202268831570963 3893 2954328
SGTC_1382 3002-2117 298 µM -0.836690287221201 0.20453116584089 no 2702 0.201383340047787 3923 1497314
SGTC_1924 st058459 75.1 µM -0.837297651001398 0.204358000746727 no 2703 0.201212639655148 3817 688683
SGTC_2612 dictamnine 15.46 µM -0.83753562175673 0.204290176863681 no 2704 0.201145781322413 3881 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2465 5809242 33.21 µM -0.839056386309959 0.203857061392118 no 2705 0.200718834347115 3908 2731748
SGTC_2006 4011487 200 µM -0.840714055236144 0.203385579346037 no 2706 0.200254072334313 3942 45595294
SGTC_2133 5320837 200 µM -0.842103312144884 0.20299094188753 no 2707 0.199865063737962 3906 2841355
SGTC_2875 9039966 71.43 µM -0.844123407789249 0.2024179226389 no 2708 0.19930022431324 3931 6463691
SGTC_1819 st053448 58.6 µM -0.847991542948155 0.201323392452164 no 2709 0.19822134030236 3821 2857616
SGTC_3197 9113331 49.47 µM -0.848809484183558 0.201092402476174 no 2710 0.197993655952813 3893 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_319 1348-1596 45.5 µM -0.850408852220206 0.200641193883417 no 2711 0.197548908134589 3993 5380505
SGTC_825 1988-2224 89.6 µM -0.851554436475992 0.200318379240769 no 2712 0.19723071879118 3896 1180859
SGTC_1348 1493-0373 93.8 µM -0.851681133626876 0.200282696374421 no 2713 0.197195547342351 3903 3010129
SGTC_2005 4024620 188 µM -0.851869124259575 0.200229757907649 no 2714 0.197143367661323 3885 236743
SGTC_2429 5902844 64.44 µM -0.852007755641552 0.200190724473147 no 2715 0.197104893749518 3949 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2313 7726885 200 µM -0.8526124226852 0.200020526231407 no 2716 0.196937135628847 3948 726423
SGTC_1717 st033143 58.0435 µM -0.852789486783797 0.19997070370754 no 2717 0.196888027537555 3915 674616
SGTC_3079 9117512 49.47 µM -0.852917315214964 0.199934739817614 no 2718 0.196852579390296 3923 7185044
SGTC_1227 3909-8010 46.6 µM -0.853864757213137 0.19966830301414 no 2719 0.196589964399649 3904 15982272
SGTC_965 1291-5240 308 µM -0.854082134921179 0.19960720284984 no 2720 0.19652974090375 3904 2834598
SGTC_2850 9015429 58.44 µM -0.856178514404141 0.199018533666298 no 2721 0.195949522516978 3977 6457570
SGTC_357 1325-0123 420 µM -0.856259779593333 0.198995735256984 no 2722 0.195927051561661 3948 1098503
SGTC_1657 st012939 43.4 µM -0.856564193666702 0.198910347899936 no 2723 0.195842890734413 3921 24207257
SGTC_1559 coumarin 343 70.1 µM -0.858846979697275 0.198270736326506 no 2724 0.195212472229784 3918 108770 A hepatotoxic, DNA x-linker.
SGTC_1728 st035614 33.7865 µM -0.860165978105529 0.197901733981403 no 2725 0.194848777922313 3910 15945546
SGTC_2251 lansoprazole 556 µM -0.861856973099958 0.197429269373984 no 2726 0.19438311434133 3834 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2225 6654152 15.4 µM -0.863553491337273 0.196955947646597 no 2727 0.193916611266562 3800 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1691 st019933 84.6 µM -0.864163741802927 0.196785858359779 no 2728 0.193748973570353 3859 6176082
SGTC_966 1300-0360 30.2 µM -0.864399379044463 0.196720205252849 no 2729 0.193684266940387 3906 70588
SGTC_1134 3477-0009 42.5 µM -0.864446316579845 0.196707129129542 no 2730 0.19367137933895 4024 3973534
SGTC_1472 k841-0093 193 µM -0.864553409442731 0.196677296566763 no 2731 0.193641976895083 4025 X1472
SGTC_1487 3970-0795 2.82 µM -0.86468750212744 0.196639946602533 no 2732 0.193605165463488 3966 3765103
SGTC_1851 st056236 18.9 µM -0.865794855760076 0.196331670355291 no 2733 0.193301335371228 3884 5393171
SGTC_1979 st071809 45.3 µM -0.867737912085888 0.195791451322334 no 2734 0.192768913118013 4017 4976333
SGTC_487 nimodipine 119 µM -0.868854264848167 0.195481485346686 no 2735 0.192463423866839 3830 4497 L-type voltage-gated calcium channels inhibitor
SGTC_593 1203-0218 61.7 µM -0.869952692241698 0.195176787591646 no 2736 0.192163128951203 3974 3666956
SGTC_2592 piperlongumine 83.33 µM -0.872978344563077 0.194338981920078 no 2737 0.191337440693082 3957 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_994 3910-0338 138 µM -0.874002443903119 0.194055904688992 no 2738 0.191058461407265 4026 3479481
SGTC_1198 1612-1005 86.7 µM -0.875214360935287 0.19372123641887 no 2739 0.190728640357942 4012 6998509
SGTC_742 0kpi-0133 140 µM -0.876037897387078 0.193494019543642 no 2740 0.190504715908815 3998 2728852
SGTC_1368 1852-0141 284 µM -0.876247812731223 0.193436129102931 no 2741 0.190447664507357 3943 2838987
SGTC_1009 4106-0057 9.87 µM -0.877289401139529 0.193149036240089 no 2742 0.190164733803789 3881 2928005
SGTC_163 TUB2.036 7.546 µM -0.879288463792903 0.192598764057352 no 2743 0.189622444635145 3939 15992207 YJR013W GPI14
SGTC_1244 0416-0015 52.5 µM -0.879869403019011 0.192439031623362 no 2744 0.189465030826351 3925 96201
SGTC_2360 9040895 200 µM -0.880666338822541 0.192220041555792 no 2745 0.189249220516555 3984 4914414
SGTC_265 mycophenolic acid 32.932 µM -0.880815802534192 0.192178987390149 no 2746 0.189208762586031 4003 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2107 5363541 170.161 µM -0.882484686247076 0.191720948707661 no 2747 0.188757378724935 3932 244052
SGTC_3163 9099914 49.47 µM -0.883278962599706 0.191503188112385 no 2748 0.188542783676834 3938 16268368
SGTC_874 0599-0792 117 µM -0.883473517539567 0.191449871605232 no 2749 0.188490242390547 3936 765305
SGTC_318 1488-0629 67.2 µM -0.885510313360667 0.190892247235624 no 2750 0.187940729830383 3992 3662576
SGTC_1478 0453-0656 35.7 µM -0.886150322473627 0.190717234494604 no 2751 0.187768264505292 3952 5258496
SGTC_2536 dehydroabietamide 32.04 µM -0.889409569536553 0.189827510443122 no 2752 0.186891501921089 4037 3983547
SGTC_2949 9072542 2.23 µM -0.890200680845953 0.189611934838099 no 2753 0.186679069576626 4032 16457352
SGTC_1864 st057645 30.4 µM -0.890380881141519 0.189562851832804 no 2754 0.186630702390338 3992 688666
SGTC_810 3825-7150 143 µM -0.891885063551138 0.189153447251638 no 2755 0.186227270675877 4023 22330411 YGL099W LSG1
SGTC_1497 4476-2978 41.3 µM -0.892234042069602 0.189058541030646 no 2756 0.186133749610271 3999 1528379
SGTC_29 0299-0004 12.984 µM -0.893381605746358 0.18874666296341 no 2757 0.185826424867498 3850 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2111 5486399 200 µM -0.895403399938552 0.188197963713274 no 2758 0.18528574191448 3923 689674
SGTC_1462 k081-0014 26.5 µM -0.896033907222313 0.188027050473638 no 2759 0.185117327075054 3618 3270634
SGTC_2959 9079155 11 µM -0.899362696340532 0.187126296176046 no 2760 0.184229751080515 4027 16189457
SGTC_875 0709-0210 25.7 µM -0.899836942842719 0.186998184906603 no 2761 0.184103515634726 3967 6251364
SGTC_2642 cholecalciferol 100 µM -0.900121007785236 0.186921474601118 no 2762 0.184027928713315 3961 9821465 A vitamin D precursor, similar to steriods.
SGTC_1917 st066507 28.5 µM -0.900768447706694 0.186746709492209 no 2763 0.183855723457431 3945 3156428
SGTC_3098 9119039 49.47 µM -0.901412357288337 0.186572997691005 no 2764 0.183684556776869 3966 17161528
SGTC_1744 st037937 38.9 µM -0.902290943703304 0.186336137014225 no 2765 0.183451167557255 4056 1016152
SGTC_1771 st048882 4.1505 µM -0.903067601125843 0.186126910878169 no 2766 0.183245008935042 3995 4580403
SGTC_1228 0124-0032 52.5 µM -0.90335549449529 0.186049391403015 no 2767 0.183168626246348 4047 X1228
SGTC_843 0310-0051 143 µM -0.907040720014326 0.185058859474871 no 2768 0.182192632128259 4000 2065037
SGTC_2528 xanthyletin 44.79 µM -0.908395720790322 0.184695481390598 no 2769 0.181834592893209 4017 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_222 nsc-310342 10.666 µM -0.908459994189954 0.184678255863407 no 2770 0.18181762052309 3929 432556
SGTC_1025 k007-0731 70 µM -0.912441133403874 0.183613242355866 no 2771 0.180768272278245 3954 6256118
SGTC_2409 alverine citrate 63.97 µM -0.913174422151679 0.183417495001847 no 2772 0.180575406982859 4172 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_790 1575-0012 79.1 µM -0.914347353499748 0.183104658092084 no 2773 0.180267177895255 4060 378741 YLR208W SEC13
SGTC_2497 7-hydroxyflavone 100 µM -0.91922673506564 0.181806835621509 no 2774 0.178988495013119 4033 5281894
SGTC_178 4092-0806 87.505 µM -0.919523939942783 0.181727971149771 no 2775 0.178910794824598 3905 2169044
SGTC_1965 Pectolinarigenin 58.4 µM -0.919884347097748 0.181632364426591 no 2776 0.178816599741055 3975 5320438 An anti-inflammatory.
SGTC_2100 5377183 190 µM -0.920503362117671 0.181468229177259 no 2777 0.17865488844269 4022 2844202
SGTC_746 1095-0025 46.6 µM -0.921003279392667 0.181335741145668 no 2778 0.178524357440778 4024 6749286
SGTC_246 cycloheximide 667 µM -0.924893145019649 0.18030691943944 no 2779 0.177510746355996 3873 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2710 st078562 53.7235 µM -0.925860947045379 0.180051517820516 no 2780 0.177259124429312 3965 17250908
SGTC_155 k072-0202 43.6 µM -0.926919746523508 0.179772362415803 no 2781 0.17698410193266 3899 5857737
SGTC_1852 st056254 31.4 µM -0.926981533167429 0.179756080597251 no 2782 0.176968061221378 3939 442583
SGTC_1618 st003135 44.5 µM -0.930977635698576 0.178705008517782 no 2783 0.175932566441792 3902 1270615
SGTC_1636 st007707 68.9 µM -0.934363367830659 0.177817513290419 no 2784 0.175058243574038 4055 403051
SGTC_1568 digitonin 820 nM -0.934443032707649 0.177796664428598 no 2785 0.175037704367065 3990 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1397 3532-0190 20.1 µM -0.934467187165887 0.177790343340683 no 2786 0.175031477164162 3947 5322280
SGTC_272 doxorubicin 8.13 µM -0.935061596205091 0.177634834459493 no 2787 0.174878278286468 3994 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2603 homopterocarpin 100 µM -0.93689921509164 0.177154620931313 no 2788 0.174405201498079 4046 101795 A weak amylase inhibitor.
SGTC_1797 st048695 56.8 µM -0.937557908054625 0.176982688625145 no 2789 0.174235825634763 4002 592262 YIL048W NEO1
SGTC_658 3253-0951 102 µM -0.93771612759628 0.176941405806003 no 2790 0.174195156743784 4029 1184878
SGTC_3320 9137005 35.139 µM -0.938196159585353 0.176816192566811 no 2791 0.174071805818089 4031 4908713
SGTC_1675 st018485 24.5 µM -0.938324797584046 0.176782647694917 no 2792 0.174038759923124 4071 3323024
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.941189342160686 0.176036704172983 no 2793 0.173303918733642 4070 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2162 5663267 200 µM -0.941745162550853 0.175892196596775 no 2794 0.173161563386765 3992 6456493
SGTC_567 1080-0542 68.4 µM -0.942614524690336 0.175666322092497 no 2795 0.17293905388525 3896 5950415
SGTC_1816 st051957 91.6 µM -0.943768803011877 0.175366705842581 no 2796 0.17264390297045 4000 674121
SGTC_2346 9031566 143.75 µM -0.944831356210337 0.175091185272255 no 2797 0.172372490387293 3990 4771086
SGTC_2244 6635614 200 µM -0.945639325511441 0.17488186232665 no 2798 0.17216628955597 3943 836499
SGTC_2734 clemastine 41.6 µM -0.945801948129082 0.174839750421732 no 2799 0.172124805880298 4049 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_339 3091-4833 71.4 µM -0.947353180473275 0.174438374940799 no 2800 0.171729420131126 3906 3240077
SGTC_1100 amiodarone 5.07 µM -0.948067791350062 0.174253669170254 no 2801 0.171547471928002 4119 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2757 clomiphene 4.22 µM -0.949333083529369 0.173926933537714 no 2802 0.171225616151417 4105 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_418 lividomycin a 100 µM -0.949398527332504 0.173910044626674 no 2803 0.171208979543599 4045 72394 An antibiotic.
SGTC_785 1270-0111 65.3 µM -0.950930324883459 0.173515035544097 no 2804 0.170819873297072 3971 6741994
SGTC_1810 st050138 53 µM -0.95436294060465 0.172631932287705 no 2805 0.169949979207236 4031 3444541
SGTC_3221 9128209 49.47 µM -0.956363467489816 0.172118584176795 no 2806 0.169444317494477 4075 16460723
SGTC_1386 3228-0095 33.8 µM -0.957053096168295 0.171941847059328 no 2807 0.169270228017513 4068 870181
SGTC_2526 patulin 37.61 µM -0.957218616088587 0.171899445083674 no 2808 0.169228461354113 4083 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2348 9022543 33.42 µM -0.958168518571232 0.171656233456259 no 2809 0.168988894550198 4092 3162678 YDL140C RPO21
SGTC_2656 pseudo-anisatin 100 µM -0.958555367346541 0.171557248291927 no 2810 0.168891393171869 4068 6708809 A neurotoxin.
SGTC_2664 lyso-paf C-16 73.48 µM -0.960346311345101 0.17109946481717 no 2811 0.168440474663167 4014 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1934 st074720 32.6 µM -0.962607432079939 0.170522616337706 no 2812 0.167872283206797 3994 17250992
SGTC_260 nsc-65238 3.989 µM -0.963732940566635 0.1702359456692 no 2813 0.167589917444551 4041 3246252
SGTC_2972 9093619 59.92 µM -0.965615018433516 0.169757264620935 no 2814 0.167118428710936 4031 25236256
SGTC_1323 1348-1351 11.2 µM -0.966000251313944 0.169659392376265 no 2815 0.167022027640251 3990 6989654
SGTC_997 3996-0078 137 µM -0.966678947010722 0.169487051059991 no 2816 0.166852277393786 4095 735687
SGTC_3014 9081533 49.47 µM -0.967213145662677 0.169351480937556 no 2817 0.166718745959232 4094 21367265
SGTC_1345 1488-0192 31.4 µM -0.967345610089066 0.169317874593096 no 2818 0.166685645045122 4102 658348
SGTC_2193 5925765 200 µM -0.967864985161902 0.169186149967999 no 2819 0.166555901760304 4040 877370
SGTC_2947 9072639 7.68 µM -0.968629491247964 0.168992374617615 no 2820 0.166365041775703 4084 16488146
SGTC_2514 salinomycin 42.74 µM -0.969031421572436 0.16889055664196 no 2821 0.166264755987591 4114 23682228 A polyether potassium ionophore.
SGTC_1907 st060210 83.7 µM -0.969126575970964 0.168866457667125 no 2822 0.16624101969443 4105 688793
SGTC_340 k038-0059 454 µM -0.971002409584583 0.168391831769432 no 2823 0.165773539337022 4035 23733424
SGTC_2705 st078069 42.8 µM -0.972640178579764 0.167978143484179 no 2824 0.165366083165375 4110 1530061
SGTC_568 1193-0097 7.48 µM -0.975675626694559 0.167213143090617 no 2825 0.164612617101401 3919 3646150
SGTC_1758 st042942 75.2445 µM -0.976459697232707 0.167015905436633 no 2826 0.164418355363606 3989 669317
SGTC_2217 6934799 96.0675 µM -0.977385686635808 0.166783160546972 no 2827 0.164189123205012 4029 675606
SGTC_361 000s-0510 1.45 µM -0.977569650700531 0.166736946613284 no 2828 0.164143606900236 4032 660
SGTC_508 roscovitine 141 µM -0.977820554756241 0.166673929888405 no 2829 0.164081541527556 4130 160355 A CDKinase inhibitor.
SGTC_2817 7995342 71.43 µM -0.979770921327145 0.166184602620193 no 2830 0.163599604464617 4065 18879975
SGTC_2413 inermin 26.06 µM -0.981647102328663 0.165714764369993 no 2831 0.163136866942783 4174 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1373 2887-0003 58.5 µM -0.981708453356844 0.165699415197294 no 2832 0.163121749824432 4045 776948
SGTC_326 k292-0812 17.5 µM -0.982193703781067 0.165578044690517 no 2833 0.163002214419583 4052 3579357
SGTC_3110 9122132 49.47 µM -0.98381651983693 0.165172564822942 no 2834 0.162602867639121 4175 918317
SGTC_1910 st062352 60.4 µM -0.985870320185874 0.164660320635281 no 2835 0.162098376454974 3999 2245730
SGTC_2357 9067248 200 µM -0.986782521340125 0.164433136416588 no 2836 0.161874632555619 4071 9150235
SGTC_2942 9052777 62.25 µM -0.987098349529438 0.164354526600487 no 2837 0.161797213409479 4134 6469503
SGTC_1461 k072-0203 53.8 µM -0.987291779708929 0.164306393751347 no 2838 0.161749809673828 3979 5418714
SGTC_3171 9103192 49.47 µM -0.987559605037756 0.164239763625339 no 2839 0.161684188938871 4109 13018434
SGTC_1796 st049173 110.4 µM -0.98761881396145 0.164225035875076 no 2840 0.161669684314626 4023 94134
SGTC_1946 st076057 65.1 µM -0.98782328368025 0.164174182239798 no 2841 0.16161960114972 4013 953009
SGTC_2256 7954252 200 µM -0.989015570231213 0.163877852251041 no 2842 0.161327761882065 4103 2972920
SGTC_1912 st060209 90.8 µM -0.991023635507994 0.163379554327719 no 2843 0.160837019630009 4094 688787
SGTC_1209 2323-2347 50.3 µM -0.992023218534752 0.16313187682302 no 2844 0.160593099622929 4098 5412760
SGTC_640 3381-0960 37.1 µM -0.992192163263847 0.163090039678601 no 2845 0.16055189731608 4131 1745025
SGTC_1394 3474-0001 65.7 µM -0.993121207310674 0.16286009764853 no 2846 0.160325445096928 4071 5017666 YIL048W NEO1
SGTC_2445 5742597 35.57 µM -0.99340545884936 0.162789786420464 no 2847 0.16025620120153 4051 1774255
SGTC_275 trichlorophene 5.69 µM -0.995286224218935 0.162325065978952 no 2848 0.159798537918747 4127 62616
SGTC_1105 epirubicin 18.1 µM -0.996590345621667 0.162003336660104 no 2849 0.159481697013741 4121 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3344 9148862 3.898 µM -0.997289842705093 0.161830940610545 no 2850 0.159311921286325 4142 4905352
SGTC_364 0083-0097 67.7 µM -0.998045131710823 0.161644928512259 no 2851 0.159128737174209 4172 5207356
SGTC_3256 9138902 49.47 µM -0.998858535923496 0.16144475976254 no 2852 0.158931612457724 4160 17228773
SGTC_3131 9127911 49.47 µM -0.99887995275481 0.161439491529233 no 2853 0.158926424351682 4157 45595681
SGTC_3243 9134147 49.47 µM -0.999463757678988 0.161295927069924 no 2854 0.158785043664434 4147 24282180
SGTC_1645 Cervolide 78 µM -1.00297765339281 0.160433578650549 no 2855 0.157935821688051 4069 23173 A fragrance.
SGTC_3060 1327-0027 12.5 µM -1.00431195852318 0.160106916162336 no 2856 0.157614135675724 3992 16000455 YPR107C YTH1
SGTC_2872 9044037 25.97 µM -1.00495159245182 0.159950476294471 no 2857 0.15746007985777 4087 6465195
SGTC_215 1287-0124 461.5 µM -1.00610576183255 0.159668445820925 no 2858 0.157182348663038 4116 5560863
SGTC_2427 5545055 42.75 µM -1.0088114711807 0.159008560604635 no 2859 0.156532529292887 4069 5372858
SGTC_2966 9084041 48.03 µM -1.00914900852322 0.158926365442434 no 2860 0.156451588571392 4000 17741380
SGTC_1591 genipin 88.4 µM -1.00992249375939 0.158738115773233 no 2861 0.156266212452988 4133 442424 A DNA cross-linking agent.
SGTC_954 1189-0853 2.85 µM -1.01046547512094 0.158606053152874 no 2862 0.15613616615592 4042 2828194
SGTC_1604 st002052 72.4 µM -1.01194620503323 0.158246279822155 no 2863 0.15578188767522 4167 6254834 YHR062C RPP1
SGTC_2644 guaiazulene 100 µM -1.01283149385435 0.158031436967098 no 2864 0.155570327426957 4102 3515 A coloring agent.
SGTC_2229 7354935 190 µM -1.0139348745969 0.15776393550417 no 2865 0.155306914496947 4025 318112
SGTC_1897 st060201 15 µM -1.0150920019264 0.157483723505939 no 2866 0.155030986905137 4154 611878
SGTC_223 busulfan 5 mM -1.01568295919405 0.157340742504244 no 2867 0.154890192696781 4108 2478 A DNA alkylator.
SGTC_2040 5100729 123 µM -1.01767855624058 0.156858542379726 no 2868 0.154415370625626 4124 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3166 9102297 49.47 µM -1.01952703938972 0.156412758083622 no 2869 0.15397641149832 4120 25237072
SGTC_2254 7938975 95.19 µM -1.01968793692969 0.156373995186762 no 2870 0.153938242275078 4199 2969277
SGTC_2756 carbadox 75.1 µM -1.02090476527896 0.156081045847274 no 2871 0.153649780614116 4071 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2541 muurolladie-3-one 83.07 µM -1.02273391014833 0.155641363217487 no 2872 0.153216836806246 4126 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1113 artemisinin 1.17947 µM -1.02598551861616 0.154861773180056 no 2873 0.152449205043655 4156 2240 An anti-malaria and mitochondrial poison.
SGTC_1060 3448-7350 82 µM -1.03188105257881 0.15345487731883 no 2874 0.151063921549662 4086 570178
SGTC_2287 7945887 168.79 µM -1.03220240565104 0.153378434478395 no 2875 0.15098865417015 4141 1245853
SGTC_716 1683-5115 658 µM -1.03334509646232 0.153106817786807 no 2876 0.150721215095823 4057 723597
SGTC_2277 7947813 106.88 µM -1.0353698633039 0.152626315730315 no 2877 0.150248107133033 4191 1246798
SGTC_1849 st056239 19.2 µM -1.03576927098418 0.152531649643431 no 2878 0.150154898350222 4128 5393181
SGTC_2299 7976368 114.88 µM -1.03644367331027 0.152371893823234 no 2879 0.149997602250724 4159 2979718
SGTC_2549 cedrol 20.94 µM -1.03822065202913 0.151951486167234 no 2880 0.149583669997386 4089 6708665 A sedative which affects the nervous system.
SGTC_457 grayanotoxin iii 135 µM -1.03913941433926 0.151734422665619 no 2881 0.14936995126559 3971 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2378 9074213 121.43 µM -1.04043516254361 0.15142864422761 no 2882 0.149068886249676 4099 657714
SGTC_2766 oltipraz 83.91 µM -1.04201065726603 0.151057401891652 no 2883 0.148703368985365 4103 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_923 1900-2434 73.3 µM -1.04306098713445 0.150810243728852 no 2884 0.1484600238965 4087 5910570
SGTC_1731 st035964 63 µM -1.04328650894596 0.150757210237952 no 2885 0.148407808750185 4071 6739575
SGTC_1372 2752-0194 270 µM -1.04493400293155 0.150370163863903 no 2886 0.148026736504089 4075 823334
SGTC_2355 9061122 103.12 µM -1.04700472452313 0.149884628339838 no 2887 0.147548699593098 4154 5302957
SGTC_3182 9108849 49.47 µM -1.04797588034081 0.149657275708864 no 2888 0.147324859834932 4178 17133045
SGTC_3266 9136860 49.47 µM -1.05076715998149 0.149005104278444 no 2889 0.146682771024441 3987 4871271 YPR165W RHO1
SGTC_1547 harmine 94.2 µM -1.05324157689915 0.148428556426223 no 2890 0.146115143772433 4114 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2354 9060492 162 µM -1.05376628425493 0.14830648975276 no 2891 0.145994966623923 4190 6471895
SGTC_1998 st075797 76.8 µM -1.05507523263215 0.148002271894947 no 2892 0.145695459190951 4142 24208315
SGTC_2203 7227154 166.4 µM -1.05527460168242 0.147955972427535 no 2893 0.145649876774169 4146 896304
SGTC_698 k064-0052 127 µM -1.06484061674929 0.145745847894593 no 2894 0.143474030693746 4239 5088751
SGTC_486 niguldipine 82 µM -1.06537723052146 0.145622529894816 no 2895 0.143352628182748 4215 1236 A calcium channel blocker.
SGTC_1114 scopoletin 1.73284 µM -1.06585771490238 0.145512170412243 no 2896 0.143243983160507 4198 5280460 A coumarin with genotoxic properties.
SGTC_145 3737-0113 38.366 µM -1.06643297703113 0.14538011601511 no 2897 0.143113980575839 4123 6849351
SGTC_2293 7624732 200 µM -1.0684903668809 0.144908491411548 no 2898 0.142649686713388 4050 894453
SGTC_3331 9141060 1.957 µM -1.06887470373666 0.144820502486615 no 2899 0.142563065938323 4119 4906567 YPR165W RHO1
SGTC_678 1218-2179 85.9 µM -1.07164309684871 0.144187777883471 no 2900 0.141940184132308 4169 6820081 YOR116C RPO31
SGTC_1393 3470-5649 58.2 µM -1.07396692003901 0.143658101977255 no 2901 0.141418754025096 4141 4108395
SGTC_2108 5365811 200 µM -1.07577674918149 0.143246492952935 no 2902 0.141013556574368 4172 780283
SGTC_749 1000-0129 128 µM -1.07601032789723 0.143193428290734 no 2903 0.140961318733836 4229 708470
SGTC_2768 sulfasalazine 50.2 µM -1.07615011215222 0.143161678305764 no 2904 0.140930063484364 4118 5384001 An antioxidant and salicylic acid derivative.
SGTC_2594 a-mangostin 100 µM -1.07649888617327 0.143082480034583 no 2905 0.140852099384531 4211 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1505 k297-0037 20.6 µM -1.07809112768529 0.142721295988587 no 2906 0.140496545334837 4177 4089396
SGTC_3022 9087993 49.47 µM -1.07818625532917 0.142699736765195 no 2907 0.140475322248713 4232 17173644
SGTC_2563 tomatine 8.54 µM -1.07935533960401 0.142434961526337 no 2908 0.140214675950323 4126 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1900 st060200 72.8 µM -1.08083179099824 0.14210104864385 no 2909 0.139885972095501 4162 688945
SGTC_1087 pterostilbene 9.05 µM -1.08254757778824 0.141713674012889 no 2910 0.139504643207802 4214 5281727 Similar to reservatol, lowers cholesterol.
SGTC_347 4534-1311 26.2 µM -1.08448710526554 0.141276647269515 no 2911 0.139074440619484 4179 2862016
SGTC_700 3453-2283 142 µM -1.08529579310139 0.141094698717804 no 2912 0.138895334276962 4231 565664
SGTC_1329 1447-1697 50.6 µM -1.08742249814582 0.140616965119086 no 2913 0.138425066374482 4195 2840515
SGTC_201 4262-0159 12.803 µM -1.0888304589596 0.140301291744101 no 2914 0.138114328543167 4214 1341029
SGTC_2056 5235370 200 µM -1.08981661045945 0.140080477391313 no 2915 0.137896967756026 4114 5511916
SGTC_2813 7971799 71.43 µM -1.09037922932899 0.13995460428819 no 2916 0.13777306374426 4211 2234054
SGTC_1815 st051655 58.2 µM -1.09441082281078 0.139054876520515 no 2917 0.136887419683201 4147 5984156
SGTC_481 bay k-8644 50 µM -1.0957585000848 0.138754996373154 no 2918 0.136592237089711 4169 2303 A calcium channel antagonist.
SGTC_170 4197-0004 226 µM -1.0972921836848 0.138414263010772 no 2919 0.136256843319021 4216 218692
SGTC_71 0417-1750 47.813 µM -1.10101555661603 0.137589427952394 no 2920 0.135444943294316 4200 6811472
SGTC_2940 9060638 45.86 µM -1.10135539292544 0.137514311793411 no 2921 0.135371005745524 4183 4027022
SGTC_106 0092-0003 11.579 µM -1.10343500954458 0.137055250935904 no 2922 0.134919150103069 4116 1072148
SGTC_3321 9137793 26.8275 µM -1.10531413994025 0.136641347499289 no 2923 0.134511746522836 4170 4904192
SGTC_814 3342-0569 96 µM -1.10780542412778 0.136093927981931 no 2924 0.133972928527059 4267 4346283
SGTC_2516 gossypol 71.55 µM -1.1107002476937 0.135459725079118 no 2925 0.133348697794334 4227 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2992 9074591 71.4286 µM -1.11200092427497 0.135175431087557 no 2926 0.133068876468886 4169 17741321
SGTC_171 k064-0041 9.68 µM -1.11480745590787 0.134563390922533 no 2927 0.132466470366948 4224 53325
SGTC_473 2-arachidonoylglycerol 10 µM -1.11524676188853 0.134467760814878 no 2928 0.132372346193287 4047 5282280 An endocannabinoid.
SGTC_1063 disulfiram 1.84 µM -1.11662674974984 0.134167662367409 no 2929 0.132076974645841 4234 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2534 helenine 20.12 µM -1.12015134889993 0.133403276203744 no 2930 0.131324635994899 4221 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1229 0139-0193 12.2 µM -1.1215856369198 0.133093078795847 no 2931 0.13101933069744 4294 3090752
SGTC_973 1325-0077 65.9 µM -1.12938897536745 0.131414129531337 no 2932 0.129366890746788 4224 2835149
SGTC_3005 9076496 71.4286 µM -1.1316460388387 0.130931242962642 no 2933 0.128891638120598 4185 21368410
SGTC_3191 9110352 49.47 µM -1.13445400695964 0.130332206753231 no 2934 0.128302077944315 4174 17122424
SGTC_3046 9092212 49.47 µM -1.13736769262683 0.129712624541325 no 2935 0.127692303606202 4293 25236637
SGTC_2213 7173844 200 µM -1.13834575320205 0.129505102377831 no 2936 0.127488068027819 4203 892728
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.13895172819578 0.129376643760656 no 2937 0.127361644232926 4320 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3037 9091026 49.47 µM -1.13932478340983 0.129297604957763 no 2938 0.127283857575257 4152 25236398 YIL048W NEO1
SGTC_1015 4130-4525 82 µM -1.13935937312073 0.12929027816903 no 2939 0.127276646864353 4233 1363237
SGTC_2704 st078022 71.1 µM -1.13976983476722 0.12920335619613 no 2940 0.127191102064044 4277 54697681
SGTC_1643 st009866 20.2 µM -1.13994075154082 0.129167173720142 no 2941 0.127155492895202 4181 3156273 YOR207C RET1
SGTC_113 0099-0221 2.5 µM -1.14013952571786 0.129125102766316 no 2942 0.127114088580301 4201 89219
SGTC_1520 flindersine 88 µM -1.14310478040788 0.128498628457108 no 2943 0.126497544874022 4303 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_455 paf C-16 10 µM -1.14568585346583 0.127955040838907 no 2944 0.125962579652965 4206 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_883 0850-0245 24.6 µM -1.14599194061595 0.127890683394675 no 2945 0.125899243396017 4305 6823229 YPR165W RHO1
SGTC_2749 bexarotene 57.39 µM -1.14778844692417 0.127513405996931 no 2946 0.125527953900807 4263 82146 An retinoic acid receptor inhibitor.
SGTC_3190 9110366 49.47 µM -1.14815197741683 0.1274371565942 no 2947 0.12545291498591 4247 17123768
SGTC_2629 bisabolol 100 µM -1.14856380793859 0.127350814723598 no 2948 0.125367943949188 4277 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1102 cgs 12066b 26.1 µM -1.14875045311802 0.127311697237818 no 2949 0.125329447567924 4248 6438352 A 5-HT1B full agonist.
SGTC_3242 9133940 49.47 µM -1.14952656696936 0.127149127317972 no 2950 0.125169459211175 4254 17248444
SGTC_3039 9090270 49.47 µM -1.15101805365992 0.126837116335747 no 2951 0.12486240418091 4254 17173750
SGTC_1756 st041558 35.5 µM -1.15144543280744 0.126747809256497 no 2952 0.12477451596278 4327 3955792
SGTC_3092 9117248 49.47 µM -1.15304513145172 0.126413917707109 no 2953 0.124445930340623 4372 17141857
SGTC_2490 carminic acid 95.39 µM -1.15321507919371 0.126378481998621 no 2954 0.124411057862102 4214 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_236 1509-0011 5.31 µM -1.15498942709409 0.126008927042158 no 2955 0.124047378080594 4301 3107280
SGTC_817 1391-0715 46 µM -1.16016426637366 0.124935435374496 no 2956 0.12299096630353 4228 1353946
SGTC_811 0416-0114 265 µM -1.1613224211758 0.124696060124386 no 2957 0.122755402392523 4285 6612453
SGTC_3294 9122953 26.2835 µM -1.16149725427928 0.12465995230451 no 2958 0.122719869568626 4234 16459826
SGTC_2281 7943571 200 µM -1.16283298433181 0.124384328693919 no 2959 0.122448635847766 4363 1244024
SGTC_534 k292-0788 63.4 µM -1.16438675038307 0.124064250581418 no 2960 0.122133657306315 4301 4146317
SGTC_2478 5763493 32.33 µM -1.16643793801698 0.12364258613087 no 2961 0.121718713625735 4192 1365576 YLR208W SEC13
SGTC_1708 st033234 31.827 µM -1.16769149057843 0.123385386822012 no 2962 0.121465615233486 4343 674664
SGTC_3067 9117431 49.47 µM -1.16991377878837 0.122930347603888 no 2963 0.121017834171545 4283 17150885
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.17485072402092 0.121923664957421 no 2964 0.120027221293488 4314 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2090 5301565 104.445 µM -1.17865482801935 0.121151937759601 no 2965 0.119267824888803 4257 2056344
SGTC_2088 5278280 127.392 µM -1.1814524741061 0.120586584601197 no 2966 0.118711511410982 4315 791502
SGTC_872 0588-0139 234 µM -1.18217660339133 0.120440554417898 no 2967 0.118567817039949 4222 2047100
SGTC_1508 1080-0625 72.9 µM -1.18588899471198 0.119693858027945 no 2968 0.117833069930102 4171 767111
SGTC_188 3229-0966 278.469 µM -1.18591919102563 0.119687797870846 no 2969 0.117827106790864 4313 5722370
SGTC_645 0845-0943 5.41 µM -1.18904850102231 0.11906094334268 no 2970 0.117210290950936 4287 1885106
SGTC_996 3970-0799 1.8 µM -1.18993282817412 0.11888421826519 no 2971 0.117036397191437 4278 6615648 YGL040C HEM2
SGTC_2763 lisinopril 49.32 µM -1.192707773512 0.118330872661296 no 2972 0.116491920083228 4181 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1791 st048313 56.1 µM -1.19393457710855 0.118086819843401 no 2973 0.116251780309693 4281 1204976
SGTC_922 1866-0035 480 µM -1.19397635650736 0.118078514777887 no 2974 0.116243608421418 4203 3156169
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.19480246564183 0.117914382545907 no 2975 0.116082108390334 4268 75037 A free radical scavenger.
SGTC_3057 9095946 49.47 µM -1.19489939893595 0.117895134323218 no 2976 0.116063168881699 4324 24540043
SGTC_1976 st070609 63.5 µM -1.20151717479335 0.116586283364118 no 2977 0.114775324172789 4233 682556
SGTC_2259 7964009 200 µM -1.20156455015768 0.116576950853935 no 2978 0.114766141543317 4324 313134
SGTC_52 0329-0193 875 nM -1.20192321401163 0.116506314567823 no 2979 0.114696639726047 4357 3739292
SGTC_2322 7413319 38.22 µM -1.20278918487188 0.116335892931615 no 2980 0.114528955513245 4281 1840400
SGTC_2219 9098279 200 µM -1.20477682324059 0.115945398041732 no 2981 0.114144734768366 4228 902349
SGTC_1312 1218-2183 165 µM -1.20538071237903 0.115826941461656 no 2982 0.114028181933214 4355 6744073
SGTC_2170 morpholine 200 µM -1.20603900067098 0.115697912083174 no 2983 0.113901226473383 4320 121171 Reacts with secondary amines.
SGTC_366 0181-0206 4.31 µM -1.20760924275784 0.115390545316771 no 2984 0.113598801155118 4312 274874
SGTC_108 0509-0257 621.132 µM -1.20789266676562 0.115335128416248 no 2985 0.113544275336749 4244 536624
SGTC_870 0573-2213 57.6 µM -1.20836330749402 0.115243147478632 no 2986 0.113453773524746 4279 3916321
SGTC_827 3253-0474 693 µM -1.21511580278591 0.113929193495386 no 2987 0.112160963592868 4327 5402065
SGTC_2681 menadione 3.18 µM -1.21588229797742 0.113780720149037 no 2988 0.112014881180208 4314 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2769 toremifene 3.73 µM -1.217635128707 0.113441707856227 no 2989 0.111681329450499 4333 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2786 7743617 45.45 µM -1.22491305315301 0.112041801680503 no 2990 0.110303990877274 4260 583674
SGTC_3146 9095609 49.47 µM -1.22503352204791 0.112018733905987 no 2991 0.110281295227291 4350 17173999
SGTC_2814 7977482 42.97 µM -1.22684135941301 0.11167297109665 no 2992 0.109941111170389 4319 6456762
SGTC_3026 9090633 49.47 µM -1.22883034417497 0.111293445298631 no 2993 0.109567710984604 4311 25236842
SGTC_1138 3761-0006 1.03 µM -1.23055874428178 0.110964393232251 no 2994 0.109243971652854 4342 12061087
SGTC_2448 5185112 27.17 µM -1.23148802092558 0.110787766275291 no 2995 0.109070197118009 4322 5718189
SGTC_1784 st039334 36.3 µM -1.2370390479329 0.109736881432499 no 2996 0.1080362931892 4359 3496984
SGTC_3315 9136395 68.55 µM -1.23854377981857 0.109453251999782 no 2997 0.107757249674279 4302 16876844
SGTC_32 0928-0142 34.1 µM -1.23933329134909 0.109304646419676 no 2998 0.107611047331503 4303 2244242
SGTC_578 3460-0051 92 µM -1.24572594888832 0.108106726340435 no 2999 0.106432511865993 4374 2876744
SGTC_861 0443-0273 110 µM -1.24613477885066 0.108030438516122 no 3000 0.106357459238721 4321 6149169
SGTC_3307 9126885 69.2785 µM -1.24630343467919 0.107998978571299 no 3001 0.106326508695292 4287 24824909
SGTC_1249 0481-0015 10.2 µM -1.24673689457024 0.107918154090444 no 3002 0.106246992995872 4239 4227577
SGTC_2224 6650123 117.647 µM -1.24810362385579 0.107663594093801 no 3003 0.10599655568325 4333 2908370
SGTC_600 1495-0418 41.6 µM -1.25031998331866 0.107251706448655 no 3004 0.105591340694124 4308 5377768
SGTC_2483 5729050 27.16 µM -1.25094997745554 0.107134836145082 no 3005 0.10547636415938 4347 2865180
SGTC_2436 5633522 8.09 µM -1.25216695795607 0.106909334031724 no 3006 0.105254516645157 4312 5724242
SGTC_2871 9038510 12.99 µM -1.25235948587163 0.106873690695329 no 3007 0.10521945102954 4311 4945164
SGTC_3188 9110789 49.47 µM -1.25272144848735 0.106806702559969 no 3008 0.105153548712955 4313 849217
SGTC_1887 st057648 70.8 µM -1.25779570727193 0.105870801267041 no 3009 0.104232824289794 4329 688672
SGTC_1968 st069590 43.6 µM -1.25801326568432 0.105830807512075 no 3010 0.104193479364762 4288 6384066
SGTC_423 5-fluorouracil 457 µM -1.25867198105387 0.105709782479022 no 3011 0.10407441789326 4266 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2931 9014674 55.67 µM -1.26043524795996 0.10538631190885 no 3012 0.103756196465896 4295 2996810
SGTC_358 0075-0058 9.45 µM -1.26279986783023 0.104953648171763 no 3013 0.103330556120491 4278 1069125
SGTC_1017 4239-0030 168 µM -1.26298704744079 0.104919454191638 no 3014 0.103296917320407 4357 1149593
SGTC_2317 5986382 200 µM -1.26312792450724 0.104893724082378 no 3015 0.103271604980966 4358 877883
SGTC_804 1595-0054 20.9 µM -1.26324039029048 0.104873186354348 no 3016 0.103251400722734 4299 761523 Stimulates phospholipase C.
SGTC_3130 9127414 49.47 µM -1.26585801629126 0.104395995696962 no 3017 0.102781959840877 4351 1494646
SGTC_1111 tnp00062 510.699 nM -1.26950810105891 0.103733218354092 no 3018 0.102129951532038 4373 676306
SGTC_1410 3909-8106 77.9 µM -1.27009604192186 0.103626746955252 no 3019 0.10202521068301 4384 1039210
SGTC_1452 4194-0072 190 µM -1.27153776620512 0.103365997871995 no 3020 0.101768700384641 4407 1343545
SGTC_2013 4024628 200 µM -1.27304488276633 0.103093931531364 no 3021 0.101501057797508 4379 5230760
SGTC_3281 9140613 49.47 µM -1.27446007925529 0.102838932532079 no 3022 0.1012502059567 4349 16013766
SGTC_3258 9138477 49.47 µM -1.27528320191895 0.102690828079353 no 3023 0.101104510596387 4366 4970355
SGTC_266 formosanin C 406 nM -1.27587456706626 0.102584519491003 no 3024 0.100999931425175 4192 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_721 1187-1332 279 µM -1.27634246304327 0.102500463428828 no 3025 0.100917242886661 4308 25730
SGTC_3268 9137683 49.47 µM -1.27801240742616 0.102200871396843 no 3026 0.100622525749047 4426 1953228
SGTC_2721 ifenprodil 61.44 µM -1.28139140387902 0.101596620738366 no 3027 0.100028110989896 4348 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2253 7938677 135.83 µM -1.28567839203659 0.100833747573642 no 3028 0.0992776626986358 4415 2301972
SGTC_460 trequinsin 123 µM -1.28643193966974 0.100700085895105 no 3029 0.0991461787514688 4439 5537 A vasodilator.
SGTC_648 0375-0473 33.3 µM -1.288620753635 0.100312574528472 no 3030 0.0987649823776614 4330 1713139
SGTC_1262 0737-0114 49.6 µM -1.29143552623546 0.0998158435845653 no 3031 0.0982763491603985 4399 765919
SGTC_989 1501-0895 10.3 µM -1.29199877575371 0.0997166614500602 no 3032 0.0981787842796224 4322 2830112
SGTC_1467 k284-1082 293 µM -1.29203002539845 0.0997111608353163 no 3033 0.0981733733610557 4330 3334705
SGTC_2937 9044753 11.33 µM -1.29330988701802 0.0994860678815454 no 3034 0.0979519512363704 4287 6465530 YGL099W LSG1
SGTC_1649 st011737 51.3 µM -1.30039165264728 0.0982472876744514 no 3035 0.0967333847079389 4382 1761035
SGTC_829 1635-0120 117 µM -1.30064853310031 0.0982025660890168 no 3036 0.0966893932258596 4380 285054
SGTC_2544 sphondin 68.51 µM -1.30089522484899 0.0981596323438258 no 3037 0.0966471604202053 4323 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1939 st074455 53.6 µM -1.302177132074 0.0979367531092802 no 3038 0.0964279202996914 4352 1644229
SGTC_2798 7813637 45.45 µM -1.30349383982902 0.0977082096214629 no 3039 0.0962031090543498 4363 956368
SGTC_450 aminopyrene 156 nM -1.30645580458102 0.0971955253399358 no 3040 0.0956987995501853 4321 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2334 9017922 200 µM -1.3082794041148 0.0968808632419867 no 3041 0.0953892791103856 4407 3163164
SGTC_3273 9137859 49.47 µM -1.3087356524984 0.0968022546870801 no 3042 0.0953119552284451 4458 2377234
SGTC_2481 5478948 45.16 µM -1.31530496760374 0.0956755932253055 no 3043 0.0942037146444921 4385 77792
SGTC_3311 9131146 2.8755 µM -1.32044797455933 0.0948003047272906 no 3044 0.0933427475546484 4330 4900406 YPR165W RHO1
SGTC_719 2810-4230 27.3 µM -1.32216686537953 0.0945090862886314 no 3045 0.0930562960082331 4394 721079
SGTC_3072 9116419 49.47 µM -1.32222405340021 0.0944994087120619 no 3046 0.0930467768588115 4400 17170162
SGTC_144 4161-2749 112.381 µM -1.32266887227879 0.0944241596940918 no 3047 0.0929727597449898 4351 797501 YMR168C CEP3
SGTC_524 r073-0010 27.8 µM -1.32392703780639 0.0942115578793328 no 3048 0.0927636387963934 4312 2772106
SGTC_1429 4049-0205 9.46 µM -1.32495668552817 0.0940378333520502 no 3049 0.0925927589968522 4432 22774478
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.32803380126334 0.0935200642164723 no 3050 0.0920834703516659 4249 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3227 9130768 49.47 µM -1.32967731308587 0.0932443836827715 no 3051 0.0918123064086728 4447 17720899
SGTC_2188 6126565 140.678 µM -1.33133317771474 0.0929672388237002 no 3052 0.0915397029964455 4289 874518
SGTC_3350 9150499 3.57 µM -1.33278855270854 0.0927241534791929 no 3053 0.0913006016908469 4392 4910996 YPR165W RHO1
SGTC_27 0485-0001 32.618 µM -1.33297588172576 0.0926928988561054 no 3054 0.0912698593622488 4384 2054479
SGTC_2303 7774051 200 µM -1.33367699311831 0.092575992150995 no 3055 0.0911548689712918 4391 2953184
SGTC_321 4534-3890 65.3 µM -1.33454617446067 0.092431212121837 no 3056 0.091012462361469 4385 699746
SGTC_34 0469-0683 81.75 µM -1.33601751042737 0.0921865128113859 no 3057 0.0907717750024162 4362 3690923
SGTC_1364 1653-0028 37.6 µM -1.33657614313686 0.0920937317723441 no 3058 0.0906805153213812 4380 5718652
SGTC_838 0109-0203 71.4 µM -1.33899397239433 0.0916929614058313 no 3059 0.0902863175881864 4411 759422
SGTC_1412 3909-8563 178 µM -1.34015980349844 0.0915001799581298 no 3060 0.0900966983791502 4482 23767530
SGTC_1438 4092-1045 4 µM -1.34203569797168 0.0911906134721088 no 3061 0.0897922106242919 4395 1351342
SGTC_1046 2001-0062 216 µM -1.34229689513894 0.0911475714980648 no 3062 0.0897498748762072 4340 739778
SGTC_220 paclitaxel 373.376 µM -1.34306912971983 0.0910204051717636 no 3063 0.0896247951909902 4368 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1343 1487-0095 224 µM -1.34775539803239 0.090251523785766 no 3064 0.0888685338512178 4402 4560101 YGL055W OLE1
SGTC_2507 purpurin 79.67 µM -1.34831556961687 0.0901599395555432 no 3065 0.0887784532550738 4398 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_173 1273-0061 2.693 µM -1.35175228900402 0.0895995700175128 no 3066 0.0882272857883715 4363 2847414 YPL266W DIM1
SGTC_209 4077-0173 175.592 µM -1.35684988643562 0.0887731639552921 no 3067 0.0874144563718938 4385 15993494
SGTC_1569 carminic acid 40.6 µM -1.35969039357807 0.0883151396230796 no 3068 0.0869639596723922 4489 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2788 5282734 71.43 µM -1.35997587352256 0.0882692043050182 no 3069 0.086918779416549 4435 743706
SGTC_3015 9080845 49.47 µM -1.3610080667033 0.088103267239994 no 3070 0.0867555701170127 4460 5296973
SGTC_1378 2093-0007 380 nM -1.36581040392394 0.0873342928020263 no 3071 0.0859992400178288 4451 3618014
SGTC_1880 MG-132 525 µM -1.36883167224586 0.0868530863916305 no 3072 0.0855259490358273 4369 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1564 D-Arginine 115 µM -1.37529108802867 0.0858309256547786 no 3073 0.0845206091659908 4421 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2666 tannic acid 100 µM -1.37640853343371 0.0856550144531473 no 3074 0.0843475937616168 4396 16134267 A thiamine antagonist.
SGTC_2669 eugenol 100 µM -1.37918891708704 0.0852184906946709 no 3075 0.0839182571325154 4436 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2058 5236698 133 µM -1.38050345838546 0.0850126873100282 no 3076 0.0837158427808699 4383 766665
SGTC_1729 st035615 45.989 µM -1.38118286714765 0.0849064658299809 no 3077 0.0836113706321187 4434 17385451
SGTC_1794 st048918 76.9 µM -1.38229592986062 0.0847326602337648 no 3078 0.0834404276049363 4382 672303
SGTC_1245 0418-0076 17.2 µM -1.38512167410224 0.0842926167228768 no 3079 0.0830076327654075 4438 6790114
SGTC_2468 5987765 72.9 µM -1.38898369140847 0.0836939747255479 no 3080 0.0824188546416729 4481 26772094
SGTC_1267 0828-0272 9.49 µM -1.39150219512016 0.0833053116656006 no 3081 0.0820365972309915 4483 745334
SGTC_309 k408-0051 1.48 µM -1.39292920491422 0.0830856942795415 no 3082 0.0818205999651284 4350 3640463
SGTC_2792 7535235 81.82 µM -1.39361783585886 0.0829798695841829 no 3083 0.0817165197998219 4403 1281891
SGTC_619 1652-1634 108 µM -1.39407085373242 0.0829103078069316 no 3084 0.0816481048047518 4416 5400454
SGTC_586 0957-0265 8.15 µM -1.39547903051766 0.0826943596313363 no 3085 0.0814357169595285 4320 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_375 3970-0961 9.27 µM -1.39571429595648 0.0826583222679341 no 3086 0.0814002737795806 4398 2898222
SGTC_598 3937-0236 20.2 µM -1.39817907641415 0.0822814837331792 no 3087 0.0810296491744618 4504 1379313
SGTC_823 0417-1665 178 µM -1.39897810891381 0.0821595983421208 no 3088 0.080909773870044 4444 3429856
SGTC_1091 telmisartan 47.6 µM -1.39960092697876 0.0820646872738358 no 3089 0.0808164281192083 4455 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1344 1488-0097 29.1 µM -1.39997833415244 0.0820072145081963 no 3090 0.0807599032554152 4466 747966
SGTC_3288 9119690 36.221 µM -1.40045526915081 0.0819346287131717 no 3091 0.0806885146591853 4422 17595618 YKL019W RAM2
SGTC_2446 5162541 200 µM -1.40494139106283 0.0812542436430645 no 3092 0.0800193535404416 4413 1549321
SGTC_1555 citronellol 128 µM -1.4173184483843 0.0793991928467161 no 3093 0.0781949218943146 4416 8842 A terpine precursor.
SGTC_213 1246-0773 967 nM -1.41855744814504 0.0792152733630351 no 3094 0.0780140394742287 4475 6251622
SGTC_549 1661-1316 519 µM -1.41895563582978 0.0791562341661817 no 3095 0.0779559752405703 4460 2857282
SGTC_3293 9120939 62.045 µM -1.42175912404647 0.0787415043422684 no 3096 0.077548094850802 4433 934087
SGTC_988 1497-1057 103 µM -1.42303618940219 0.0785531303403062 no 3097 0.0773628322980119 4436 3533044
SGTC_947 3447-0010 211 µM -1.42514880631663 0.0782422582264551 no 3098 0.0770570954865633 4410 748350
SGTC_703 3875-0075 71.8 µM -1.42748370170679 0.0778997642277371 no 3099 0.0767202598648878 4494 2850814
SGTC_713 1488-1073 324 µM -1.43337849581766 0.0770401496169591 no 3100 0.0758748502142045 4500 3312542
SGTC_3207 9114163 49.47 µM -1.4368382764077 0.0765389916445313 no 3101 0.07538197579784 4441 849233
SGTC_680 0417-1641 114 µM -1.44202722556998 0.0757920131770129 no 3102 0.0746473466367048 4484 2835990
SGTC_1230 0170-0365 3.77 µM -1.45081320769535 0.0745399000116517 no 3103 0.0734159404358887 4498 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_308 4092-1169 104 µM -1.45434766135715 0.074040672786312 no 3104 0.0729249713813412 4440 2268590 YDL196W YDL196W
SGTC_2059 5238311 157 µM -1.45590390947258 0.0738216707257934 no 3105 0.0727095923950877 4431 703021
SGTC_2190 6049624 200 µM -1.4559866212782 0.0738100450281044 no 3106 0.0726981590338816 4365 2265554
SGTC_2491 paeonol 100 µM -1.45632897351939 0.0737619400119962 no 3107 0.0726508498774488 4435 11092 Increases levels of cortical cytochrome oxidase.
SGTC_795 0685-0265 78 µM -1.45900331736738 0.0733869837493699 no 3108 0.0722820973193039 4472 302754
SGTC_2720 fluspirilene 36.88 µM -1.45952267007046 0.0733143372653063 no 3109 0.0722106528516711 4457 3396 An atypical antipsychotic.
SGTC_1488 4013-0813 75.9 µM -1.46157403670019 0.073027932032628 no 3110 0.0719289867260348 4455 2910057
SGTC_3184 9108758 49.47 µM -1.46424339323886 0.0726565281032531 no 3111 0.0715637288635484 4503 902885
SGTC_228 caffeine 993.056 µM -1.4668768942078 0.0722915322265915 no 3112 0.071204773538524 4468 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1449 4112-4002 201 µM -1.46793298237462 0.0721455567052181 no 3113 0.0710612140008243 4504 2059539
SGTC_2097 5376186 200 µM -1.4684642764299 0.0720722051998495 no 3114 0.0709890765371061 4446 742755
SGTC_3356 9151811 4.48 µM -1.46880423726993 0.0720252995398895 no 3115 0.0709429472235528 4498 1859254 YPR165W RHO1
SGTC_944 3370-0224 231 µM -1.47010610479729 0.071845892441389 no 3116 0.0707665096062388 4459 4580514
SGTC_2683 piperine 63.03 µM -1.47057930707947 0.071780766615442 no 3117 0.0707024617475357 4497 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1200 1643-0193 18.4 µM -1.47243178583476 0.0715262494237665 no 3118 0.0704521574830543 4490 5403974
SGTC_99 0109-0120 622.8 µM -1.4773385837475 0.0708554373404658 no 3119 0.0697924501225935 4487 759414
SGTC_990 3985-0011 41.3 µM -1.4779277902395 0.0707752125830366 no 3120 0.0697135535119638 4450 5399565 YGL099W LSG1
SGTC_1304 1165-0502 251 µM -1.4795065123166 0.070560602093419 no 3121 0.0695024960622222 4475 767425
SGTC_1808 st050063 61.5 µM -1.47971954107919 0.0705316814395662 no 3122 0.0694740542220393 4450 4011993
SGTC_2051 5263410 176 µM -1.48215535883201 0.0702016437295192 no 3123 0.0691494808208598 4452 227584
SGTC_2383 9036125 200 µM -1.48254512999812 0.070148942651551 no 3124 0.0690976523222515 4431 79580
SGTC_391 gliotoxin 8.33 µM -1.48626653393268 0.0696473017251902 no 3125 0.068604317497081 4530 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2314 7727897 200 µM -1.48699467792977 0.069549472606397 no 3126 0.068508108291893 4463 900724
SGTC_1632 st005650 90 µM -1.48800185458215 0.0694143287544177 no 3127 0.0683752022703212 4515 2759605
SGTC_1651 st011928 86.1 µM -1.49108508006014 0.0690018759569443 no 3128 0.0679695794798889 4504 720198
SGTC_2405 ticlatone 3.52 µM -1.49420004793724 0.0685870976552357 no 3129 0.0675616700475617 4304 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2180 6301957 200 µM -1.4959200095491 0.0683588990717027 no 3130 0.067337250647008 4516 845462
SGTC_3051 9093778 49.47 µM -1.49647181463981 0.0682858117336697 no 3131 0.0672653737230965 4586 17217378
SGTC_1972 st070201 17.4 µM -1.49802936864501 0.0680798369083832 no 3132 0.0670628101356027 4507 2829099
SGTC_1366 1683-0113 21.9 µM -1.49910296189156 0.0679381417316304 no 3133 0.0669234616722654 4492 708623
SGTC_1313 1220-0047 237 µM -1.50234812248932 0.0675112227099051 no 3134 0.0665036133290439 4487 3528706
SGTC_1742 st038235 28.8875 µM -1.50377628112618 0.067323998664957 no 3135 0.0663194901823011 4528 564103 YBR002C RER2
SGTC_1574 spiramycin 23.7 µM -1.50465374663343 0.0672091667882884 no 3136 0.0662065602283573 4463 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1975 st070967 30.8 µM -1.5109282155513 0.0663924497718642 no 3137 0.0654033705805412 4487 261391
SGTC_1053 3366-3204 134 µM -1.51185042113728 0.0662730612573552 no 3138 0.065285959550751 4507 3632071 YPR165W RHO1
SGTC_1790 st045711 43.5 µM -1.51219566086954 0.0662284094010779 no 3139 0.0652420472848418 4481 585119
SGTC_2320 7373003 200 µM -1.51446271570661 0.0659357767020626 no 3140 0.0649542616249683 4485 5415828
SGTC_3109 9122853 49.47 µM -1.52437842001488 0.0646676135038106 no 3141 0.063707103839274 4523 1234709
SGTC_109 0132-0036 33.701 µM -1.52604357626585 0.0644565194586658 no 3142 0.0634995062439438 4402 67274 A color developer.
SGTC_3189 9110682 49.47 µM -1.52789921011696 0.0642219094737428 no 3143 0.0632687821829301 4519 17122418
SGTC_1303 1160-0052 261 µM -1.53049609573831 0.0638946972041395 no 3144 0.0629469895695848 4465 3562476
SGTC_2037 5169046 200 µM -1.53152032528388 0.0637659995338801 no 3145 0.062820423507561 4568 5718022
SGTC_143 4032-1194 15.74 µM -1.53522005087058 0.0633027965457667 no 3146 0.0623648923575734 4542 1806963
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.53584047744315 0.0632253767052507 no 3147 0.0622887547633089 4491 688761
SGTC_421 streptovitacin 30 mM -1.54087003705421 0.0626004823803113 no 3148 0.06167420975803 4509 91467 include heat shock
SGTC_2911 7942208 15.64 µM -1.54134229572947 0.0625420550331884 no 3149 0.061616750034168 4531 1243384
SGTC_2893 9048488 25.97 µM -1.54457420580938 0.0621433467856154 no 3150 0.0612246446725369 4545 6467338
SGTC_808 0711-0032 135 µM -1.552392676108 0.0611870134315641 no 3151 0.0602841474044797 4486 4252555
SGTC_889 0919-1524 82.7 µM -1.55251580102382 0.0611720456448846 no 3152 0.0602694274532209 4536 3905452
SGTC_701 4424-0219 185 µM -1.55275335576158 0.0611431751843013 no 3153 0.0602410350256496 4541 2911779
SGTC_3172 9105863 49.47 µM -1.553553776914 0.0610459769229298 no 3154 0.0601454461419646 4618 2348785
SGTC_665 3914-0008 307 µM -1.56187826136751 0.0600422483476234 no 3155 0.0591583352626684 4499 1069549
SGTC_2227 7312221 64.1025 µM -1.56700712027483 0.0594302970439712 no 3156 0.0585565136571325 4626 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1981 st071826 47 µM -1.56710968801045 0.0594181091975862 no 3157 0.0585445275425448 4566 11838600
SGTC_1283 0922-0125 16.4 µM -1.57197110041623 0.0588426848274373 no 3158 0.0579786268112005 4533 3360884
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.57372954119221 0.0586356260461561 no 3159 0.0577749946238098 4513 688803
SGTC_637 1181-0519 7.26 µM -1.57888181056887 0.0580322315269025 no 3160 0.057181584440073 4539 6252091 YGR060W ERG25
SGTC_1558 st069300 45.6 µM -1.59413707608379 0.056274237226275 no 3161 0.0554526681454624 4504 24208000
SGTC_2961 9083290 32.55 µM -1.59996079534504 0.0556142989224582 no 3162 0.0548036404489997 4516 17741490
SGTC_169 k015-0017 16.025 µM -1.60039266014551 0.0555656047338009 no 3163 0.0547557511883222 4515 1840002
SGTC_3099 9120367 49.47 µM -1.60330376263652 0.0552382457645886 no 3164 0.0544338030971972 4577 24824940
SGTC_643 k048-0106 28.4 µM -1.60600697813769 0.0549356298562638 no 3165 0.0541361883703163 4574 6763920
SGTC_1318 1280-3875 124 µM -1.61149761694418 0.0543250053187505 no 3166 0.0535356531027453 4570 373245
SGTC_3102 9121669 49.47 µM -1.61478159523469 0.0539623618688333 no 3167 0.0531790000913462 4581 41905072
SGTC_351 caspofungin 25 nM -1.61623346907316 0.0538026463738231 no 3168 0.0530219225435409 4549 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.62166281536273 0.053208698287198 no 3169 0.0524377823968857 4631 688801
SGTC_1184 1269-1718 139 µM -1.6249197400137 0.0528549059845624 no 3170 0.0520898307327811 4605 5403821
SGTC_527 4476-4215 268 µM -1.62689837275909 0.0526408844625269 no 3171 0.0518793418248927 4545 4418754
SGTC_1650 st011916 45.8 µM -1.62786216488031 0.0525368839432349 no 3172 0.0517770577602088 4519 242528
SGTC_1031 k035-0009 16 µM -1.63114716259678 0.0521836324173157 no 3173 0.051429635571595 4594 5180959
SGTC_1167 k781-0610 148 µM -1.63158306709446 0.0521368996260002 no 3174 0.0513836738648232 4591 4525169
SGTC_1565 sinapyl alcohol 95.1 µM -1.63263681454765 0.0520240659493518 no 3175 0.0512727018326986 4557 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2470 5664817 21.68 µM -1.63352986693541 0.0519285912126645 no 3176 0.0511788022288489 4617 2859561
SGTC_2833 9001315 45.46 µM -1.64004438394296 0.0512363407418695 no 3177 0.050497969438709 4500 2989378
SGTC_2245 6637752 200 µM -1.64251623426549 0.0509756045255062 no 3178 0.050241532280056 4576 681890
SGTC_2772 vinpocetine 57.06 µM -1.64311193679837 0.0509129267121663 no 3179 0.050179887788912 4560 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1056 3448-1962 115 µM -1.6433125338128 0.0508918343837189 no 3180 0.0501591431834172 4525 715507
SGTC_2080 5212524 12.4 µM -1.64431657071566 0.0507863666734877 no 3181 0.0500554141083581 4532 260183
SGTC_5 0352-0601 109.883 µM -1.64558018504891 0.0506538794328198 no 3182 0.049925110730254 4473 762456
SGTC_2222 6885208 172.143 µM -1.64738797733488 0.0504648150935943 no 3183 0.0497391624757827 4590 609514
SGTC_1498 4478-3555 97.6 µM -1.64817389976831 0.0503827965103799 no 3184 0.0496584955537995 4574 3437919
SGTC_2706 st078239 82.5 µM -1.64899083697825 0.0502976538656044 no 3185 0.0495747559658996 4546 15434492
SGTC_2762 leflunomide 42.06 µM -1.65073603850415 0.0501161500281663 no 3186 0.0493962428067328 4539 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1476 4112-3294 3.34 µM -1.6663466546961 0.0485157507087505 no 3187 0.0478221946383425 4553 704369
SGTC_962 1254-0300 21.5 µM -1.66803369340241 0.0483452703800202 no 3188 0.047654519205109 4557 7340576
SGTC_392 N-ethylmaleimide 8.33 µM -1.67440812535958 0.047705436454533 no 3189 0.0470252085011325 4553 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1387 3342-1166 1.8 µM -1.67485234526526 0.0476611018201471 no 3190 0.0469816027960636 4571 3418228
SGTC_979 1426-2828 121 µM -1.67678497110192 0.0474686032260669 no 3191 0.0467922688142724 4637 747872
SGTC_898 1000-0849 28.3 µM -1.67699800003529 0.047447422714208 no 3192 0.0467714364669804 4580 6751807
SGTC_3300 9124615 50.48 µM -1.67764794672299 0.047382848218262 no 3193 0.0467079234001998 4572 24824903
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.67807491775965 0.0473404654797748 no 3194 0.0466662372823218 4609 15053
SGTC_3198 9112019 49.47 µM -1.67882415178855 0.0472661671463463 no 3195 0.0465931600777797 4613 45595555
SGTC_43 0570-0105 72.5 µM -1.68097895076274 0.047053005754511 no 3196 0.0463835015973817 4542 1114046 YDL195W SEC31
SGTC_81 0411-0046 9.971 µM -1.68345006213645 0.0468095030088023 no 3197 0.0461439994490677 4603 12925265
SGTC_2979 9012552 45.46 µM -1.68456924121507 0.0466995524433173 no 3198 0.0460358549768228 4598 17100905
SGTC_300 r073-0011 5.04 µM -1.68591825612708 0.0465672978236113 no 3199 0.0459057725541162 4590 2735780
SGTC_894 0960-0238 55.9 µM -1.68867315199333 0.0462981472977068 no 3200 0.0456410417232593 4583 6741907 YDL195W SEC31
SGTC_1214 0358-0031 63.7 µM -1.68986336583423 0.0461822516695511 no 3201 0.0455270488171762 4591 4301366
SGTC_535 2293-4129 48.2 µM -1.69997575308043 0.045206943497223 no 3202 0.0445677432059569 4571 396118 YIL048W NEO1
SGTC_1494 4358-1428 177 µM -1.70411019354905 0.0448129928261917 no 3203 0.0441802513007728 4607 1564571
SGTC_3324 9138759 60.749 µM -1.7055143354752 0.044679829500622 no 3204 0.0440492704858809 4594 45595710
SGTC_3304 9125678 46.087 µM -1.705609351071 0.0446708301176987 no 3205 0.0440404185877736 4538 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3267 9137951 49.47 µM -1.70682268207001 0.0445560380213476 no 3206 0.0439275076005631 4612 16643986
SGTC_666 0272-0154 136 µM -1.70879398116853 0.0443700420593259 no 3207 0.0437445590125374 4588 6870312
SGTC_1833 st055984 71 µM -1.71572206403077 0.0437213221369446 no 3208 0.0431064622272105 4627 676288
SGTC_1620 st003704 16.5 µM -1.71864228625081 0.043450185985297 no 3209 0.0428397634508706 4607 2834414
SGTC_594 1487-1584 10.8 µM -1.72857289019039 0.0425382930345556 no 3210 0.0419427825400312 4575 5013332
SGTC_279 1273-0055 2.93 µM -1.75127061940695 0.0405121002855782 no 3211 0.0399496530482007 4648 2847562
SGTC_2163 5671233 125 µM -1.7516031628995 0.0404830074351078 no 3212 0.0399210341710401 4562 701023
SGTC_482 fipronil 114 µM -1.75259608351623 0.0403962418494604 no 3213 0.0398356820137287 4711 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2216 7189485 200 µM -1.7579622663651 0.0399299320147673 no 3214 0.0393769649603657 4635 731273
SGTC_115 0527-0192 112.043 µM -1.76466569163294 0.0393535746969407 no 3215 0.0388099839309862 4574 4233931
SGTC_2654 protoveratrine a 100 µM -1.7664555353837 0.0392008350859795 no 3216 0.0386597275240472 4631 5702278 A heart drug and vasodilator.
SGTC_1259 0671-0132 43 µM -1.78229455741245 0.0378701073892509 no 3217 0.0373506048935637 4559 X1259
SGTC_999 SEC7.066 22.7 µM -1.7871291116642 0.0374713509045794 no 3218 0.0369583116461036 4603 740511 YDR170C SEC7
SGTC_3143 9086658 49.47 µM -1.78932391512945 0.03729145752532 no 3219 0.0367813323666768 4576 25236626
SGTC_1993 st073995 70.8 µM -1.79169916048029 0.0370975701234036 no 3220 0.0365905845510508 4618 3098394
SGTC_40 0327-0103 19.753 µM -1.79767710525594 0.0366132443173627 no 3221 0.0361140957923418 4476 409036
SGTC_647 0140-0236 81 µM -1.82728913256346 0.0342898247519186 no 3222 0.0338281541687914 4652 990837
SGTC_2004 4023728 41.89 µM -1.82877316383169 0.0341766487193781 no 3223 0.0337167983959985 4582 360084 YDR527W RBA50
SGTC_301 4119-0100 24.5 µM -1.83198626802416 0.0339326612042188 no 3224 0.0334767332537443 4643 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3137 9097352 49.47 µM -1.83895483286761 0.0334084235081778 no 3225 0.0329609148529938 4607 44120435
SGTC_3201 9113999 49.47 µM -1.84133372885509 0.0332309957463388 no 3226 0.0327863339379868 4607 16649224
SGTC_2838 9002687 71.43 µM -1.84855664928345 0.0326970312625591 no 3227 0.0322609286413395 4626 6457060
SGTC_2964 9083345 53.42 µM -1.85022368302576 0.0325748036048756 no 3228 0.0321406584414187 4605 17741579
SGTC_1388 3346-4487 254 µM -1.85642084651121 0.0321237249354567 no 3229 0.0316967978106836 4666 3345614
SGTC_880 0833-0487 87.2 µM -1.86469189166475 0.0315297388870058 no 3230 0.0311123019838179 4641 76075
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.88364188557332 0.0302030188659642 no 3231 0.0298067160830463 4687 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_941 3237-0776 460 µM -1.88451183638963 0.0301432403230938 no 3232 0.0297478876428242 4649 760008
SGTC_753 1322-0200 289 µM -1.88478225939754 0.0301246782411225 no 3233 0.0297296205423058 4696 5403907
SGTC_1212 0520-0165 585 µM -1.88637303155504 0.0300156779250308 no 3234 0.029622352044285 4662 5403258
SGTC_1513 0337-0559 19 µM -1.89238608781791 0.029606611448292 no 3235 0.0292197791413353 4629 775073
SGTC_2377 9073351 62.6 µM -1.89239597723692 0.0296059425043451 no 3236 0.0292191208087621 4649 7337946 YHR072W ERG7
SGTC_168 3970-0862 530.542 µM -1.89260589054719 0.0295917464248617 no 3237 0.0292051499140508 4584 3135186
SGTC_2339 9000433 200 µM -1.90789338306936 0.0285729648467785 no 3238 0.0282024988441589 4617 2988954
SGTC_585 0kpi-0023 191 µM -1.90872950460074 0.0285180964620229 no 3239 0.0281484974839453 4617 64601
SGTC_307 1501-1223 22.3 µM -1.91061201362397 0.0283948822902956 no 3240 0.0280272296738514 4669 2830329
SGTC_1561 5-methoxyflavone 52.9 µM -1.91317577924129 0.0282277911790357 no 3241 0.0278627765678992 4646 94525
SGTC_538 2922-0838 53.3 µM -1.91640104022575 0.0280187509785313 no 3242 0.0276570342613065 4678 777039
SGTC_2495 cafestol 54.53 µM -1.91715944893943 0.0279697835778453 no 3243 0.0276088389992664 4646 16667697 An anti-infammatory.
SGTC_773 4358-1457 44.6 µM -1.91795154072465 0.027918717512633 no 3244 0.027558578007008 4656 1186886
SGTC_2290 7904846 200 µM -1.9243565240251 0.0275086353692604 no 3245 0.0271549550105111 4686 2962154
SGTC_970 1315-0089 19.5 µM -1.92930361913433 0.0271953433356666 no 3246 0.0268465903617241 4649 6811083 YLR033W RSC58
SGTC_1834 st055981 52.8 µM -1.9365090745785 0.0267443624636128 no 3247 0.0264026911075917 4636 471719 YDL150W RPC53
SGTC_1690 st023502 41.2 µM -1.94156870749241 0.0264314326560264 no 3248 0.0260946671041598 4685 24207482
SGTC_131 0141-0277 33.849 µM -1.94380892676027 0.026293859388173 no 3249 0.0259592484455949 4620 1547771
SGTC_2015 5119600 184 µM -1.94669704253963 0.0261173821693709 no 3250 0.0257855332004927 4640 2828786
SGTC_132 0417-1715 25.805 µM -1.94984290760484 0.0259262834680641 no 3251 0.025597422830774 4646 6769098
SGTC_386 1509-0011 3.07 µM -1.9530331408539 0.0257336856727084 no 3252 0.0254078341687941 4677 3107280
SGTC_2674 ligustilide 100 µM -1.95639675031679 0.0255319193500537 no 3253 0.0252092173452676 4707 5319022 A signalling regulator.
SGTC_3212 9128307 49.47 µM -1.95681796212554 0.0255067465148255 no 3254 0.0251844372398496 4566 27243542
SGTC_1857 st056007 79.3 µM -1.9660021820141 0.0249630171791702 no 3255 0.0246491792800071 4671 619834
SGTC_1685 st024049 53.0905 µM -1.96905151122982 0.0247846519133145 no 3256 0.0244735880829603 4702 1941139
SGTC_1086 cerivastatin 2.18 µM -1.97349262551882 0.0245267896986018 no 3257 0.024219731964281 4684 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1932 st074806 40.9 µM -1.98250293446504 0.0240105429479778 no 3258 0.0237114896404231 4683 17251235
SGTC_2622 2-methoxyxanthone 59.94 µM -1.99531923442296 0.0232919852994972 no 3259 0.0230040366950075 4660 71034 A hepatoprotective.
SGTC_587 k089-0003 57 µM -1.99694885549745 0.0232019295521315 no 3260 0.0229153695840006 4637 9659696
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -2.00903057345737 0.0225433726885966 no 3261 0.0222669457393405 4664 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1795 st049545 62.3 µM -2.01343765370121 0.0223071049909109 no 3262 0.0220343038596385 4662 5291882
SGTC_1112 tnp00069 1.16933 µM -2.01736012299947 0.0220985781132172 no 3263 0.0218289727700328 4677 145826
SGTC_878 0828-0289 13.7 µM -2.02120414031413 0.0218958205644012 no 3264 0.021629318649442 4674 745350 YLR208W SEC13
SGTC_1701 st028638 40.4 µM -2.02448537624212 0.0217239925542024 no 3265 0.0214601175688706 4691 3490878
SGTC_211 3455-0679 143.504 µM -2.02731279090642 0.0215768447675763 no 3266 0.0213152171153355 4652 748649
SGTC_48 0382-0018 55 µM -2.03624823824102 0.0211173409586982 no 3267 0.0208627173089171 4690 762596
SGTC_1301 naphtanilide LB 4.81 µM -2.03995344392475 0.0209292442194278 no 3268 0.0206774814728039 4725 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2271 7849410 118.62 µM -2.0417486570316 0.0208386204627925 no 3269 0.0205882347765646 4641 972430
SGTC_1642 st009582 77.7 µM -2.05346513481459 0.0202552863740164 no 3270 0.0200137439005069 4698 6739311
SGTC_1590 st077108 57.8 µM -2.05520435715836 0.0201698861356934 no 3271 0.0199296352339888 4705 5489485
SGTC_1760 st045453 10.4495 µM -2.06468315552852 0.0197098013289091 no 3272 0.0194764947021854 4703 3323419 YIL048W NEO1
SGTC_2990 9074105 71.4286 µM -2.06498003716685 0.0196955362909638 no 3273 0.0194624445917861 4636 6502001
SGTC_2722 naftopidil 47.16 µM -2.06880004425386 0.0195127671724747 no 3274 0.0192824271413792 4661 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2905 7799065 20.05 µM -2.07047874379289 0.0194329061875424 no 3275 0.0192037672858455 4626 1296806
SGTC_2686 alizarin 95.37 µM -2.07497314642213 0.0192204590934503 no 3276 0.0189945118136227 4674 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1194 1488-0194 225 µM -2.07911871481622 0.0190262545879409 no 3277 0.0188032201827461 4710 1391452
SGTC_3301 9125354 19.7965 µM -2.08552941928397 0.0187292233477851 no 3278 0.0185106352875535 4683 41905162
SGTC_1320 1313-0481 95.3 µM -2.09008134605942 0.0185207199390602 no 3279 0.0183052465224901 4674 6813365 YLR208W SEC13
SGTC_616 4092-0450 108 µM -2.09526355886813 0.018285755045648 no 3280 0.0180737849934093 4714 787165
SGTC_1305 1181-0477 144 µM -2.10046385312756 0.0180525281817277 no 3281 0.0178440285684384 4720 6252086
SGTC_1718 roemerine 11.9335 µM -2.10284579231112 0.0179465508264036 no 3282 0.017739625820583 4341 235224 An aporphine alkaloid with mutagenic activity.
SGTC_282 k297-0036 65.7 µM -2.10309377949046 0.0179355479230087 no 3283 0.017728786313055 4699 5061378
SGTC_781 4335-2806 94.4 µM -2.1092113290804 0.0176659350661529 no 3284 0.0174631722312391 4716 845254
SGTC_1256 0570-0116 285 µM -2.13603223190224 0.0165243365059803 no 3285 0.0163383933563909 4698 410638
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.14624202687037 0.016106674431124 no 3286 0.0159268370835696 4698 1377
SGTC_1451 4152-0210 104 µM -2.15262510319237 0.0158501780394032 no 3287 0.0156740770058465 4722 659563
SGTC_2989 9073649 71.4286 µM -2.16849376171754 0.0152276463365506 no 3288 0.0150605693750943 4678 21367202
SGTC_777 1315-0167 517 µM -2.16978903855083 0.0151777723591844 no 3289 0.0150114155710077 4732 4221767
SGTC_2079 5212404 121 µM -2.17008250150934 0.015166492236299 no 3290 0.015000298272912 4688 758462
SGTC_150 3970-0969 77.2 µM -2.21106115385188 0.0136604607033525 no 3291 0.0135158012623211 4716 6615640
SGTC_3346 9158254 43.5805 µM -2.21601738253783 0.0134873677960649 no 3292 0.0133451558490104 4711 17639500
SGTC_1883 5-benzylidenerhodanine 20 µM -2.21721056601743 0.0134459805821402 no 3293 0.013304352949287 4724 1273210
SGTC_426 0988-0037 14.6 µM -2.22127626637388 0.0133057784887125 no 3294 0.0131661276722401 4709 5383008
SGTC_128 0906-2981 13.371 µM -2.22155147699495 0.0132963338905648 no 3295 0.0131568160959928 4719 6740226
SGTC_774 k060-0086 136 µM -2.24306265449853 0.0125758124575836 no 3296 0.0124463872426965 4722 5911235
SGTC_1793 st048256 72.231 µM -2.25030806688776 0.0123408567876096 no 3297 0.0122146981074474 4742 672022
SGTC_690 glyoxal 20.3 µM -2.25495656936519 0.0121921248920041 no 3298 0.0120680274931311 4565 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3185 9108267 49.47 µM -2.30946695491605 0.0105606871700274 no 3299 0.0104588416727557 4740 4910486
SGTC_2482 5981709 142.65 µM -2.32669079220203 0.0100863752975213 no 3300 0.00999086414111917 4715 877755
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.32693115124282 0.01007988996219 no 3301 0.00998446495612816 4722 6857784
SGTC_2007 4011539 71.82 µM -2.34458803396423 0.00961331766588111 no 3302 0.00952405658837318 4733 45595301
SGTC_1831 st055328 12 µM -2.34517967842075 0.00959801618533268 no 3303 0.00950895609741398 4733 1103068
SGTC_12 0849-0099 9.267 µM -2.35438426111336 0.00936268881836713 no 3304 0.00927671024172518 4746 6071388
SGTC_1842 st055362 61.2 µM -2.36369629632308 0.0091297658983556 no 3305 0.00904681921646799 4746 676032
SGTC_3206 9114350 49.47 µM -2.36396241012905 0.00912318479857753 no 3306 0.00904032351312606 4650 17087243
SGTC_514 4466-0038 2.65 nM -2.38446050869359 0.00862857878639167 no 3307 0.00855209184493522 4606 5722064
SGTC_140 0062-0056 502.533 µM -2.38511684816932 0.00861313804901186 no 3308 0.00853684868034275 4673 3758964
SGTC_2835 9006588 71.43 µM -2.39415379181188 0.00840299034475838 no 3309 0.00832938105247634 4682 2345538
SGTC_1384 3089-0840 101 µM -2.40727373436217 0.00810590855459456 no 3310 0.0080360590388748 4752 1069836
SGTC_1317 1273-0028 910 nM -2.41966006103764 0.00783394978472423 no 3311 0.00776751107569351 4752 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_304 1310-0298 97 µM -2.4331666328301 0.00754657379092582 no 3312 0.00748370550401838 4551 1550234
SGTC_1548 st061468 90.8 µM -2.45955239350385 0.00701184235703176 no 3313 0.00695551955530679 4780 390799
SGTC_1224 0823-0416 294 µM -2.46245909282154 0.00695503091948774 no 3314 0.00689939563692568 4765 3598164
SGTC_432 NS 1619 61.3 µM -2.48523623276445 0.00652374300100559 no 3315 0.00647327449141458 4732 4552 A K+/calcium channel activator.
SGTC_480 am 92016 50 µM -2.49082724914171 0.00642156198312014 no 3316 0.00637230346330689 4764 2129 K+ channel blocker.
SGTC_2584 androsterone 48.74 µM -2.52945288051413 0.00575351764343055 no 3317 0.00571202561691412 4691 2754130 A steroid.
SGTC_433 pimozide 108 µM -2.54570305141447 0.00549141408920349 no 3318 0.00545289582819374 4726 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_906 1165-0455 526 µM -2.54580785147515 0.0054897587510901 no 3319 0.00545125913082667 4756 3252859
SGTC_2081 5214970 32.255 µM -2.5558909469092 0.00533255297194936 no 3320 0.00529581536259655 4748 2063512
SGTC_1170 0310-0127 64.8 µM -2.60578776420427 0.00461204881349894 no 3321 0.00458316198546016 4765 774975
SGTC_1753 st043925 64 µM -2.61269575249288 0.00451946861995795 no 3322 0.00449156159974748 4775 670181
SGTC_2273 7815444 169.05 µM -2.62972760090278 0.0042982605296434 no 3323 0.00427266545277233 4734 2824616
SGTC_1748 st037455 53.6035 µM -2.63582977063845 0.00422139298100925 no 3324 0.00419659130092636 4750 580690
SGTC_2017 5132927 60.65 µM -2.63720875040951 0.00420419354037037 no 3325 0.00417956866061278 4751 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2459 5811157 9.22 µM -2.64687309520174 0.00408540285969164 no 3326 0.00406199168640295 4758 2870684 YBR192W RIM2
SGTC_1583 clindamycin 39.6 µM -2.65231022167243 0.00401990026644543 no 3327 0.00399715271181974 4766 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2057 5236571 38.335 µM -2.66358159429254 0.00388709775658864 no 3328 0.00386568296820244 4737 54684039 YBR257W POP4
SGTC_3295 9122362 53.5725 µM -2.66462628867467 0.00387499018604603 no 3329 0.00385369604283733 4766 4730473
SGTC_2373 9071805 200 µM -2.6688413224927 0.0038264822214323 no 3330 0.00380566995837172 4778 10149009
SGTC_1676 st018489 23.4 µM -2.67944504542799 0.00370684945496642 no 3331 0.00368721534965377 4763 3696235
SGTC_138 0850-0259 40.9225 µM -2.69735377239103 0.00351240027104587 no 3332 0.00349464868443447 4727 6813004
SGTC_2077 5212015 200 µM -2.7396094506498 0.00308941882961828 no 3333 0.00307561149591068 4765 780900
SGTC_35 0133-0054 64.071 µM -2.75981314135653 0.00290387037843406 no 3334 0.00289172153901831 4741 99677
SGTC_851 0394-0702 453 µM -2.98131612028287 0.00143620604496631 no 3335 0.00143506175643116 4782 762646
SGTC_850 0388-0143 75.9 µM -2.99542293504791 0.00137109739592861 no 3336 0.00137032272541039 4798 67273
SGTC_2014 4013930 200 µM -2.9976106305279 0.00136124533463849 no 3337 0.00136052538835487 4772 64556
SGTC_911 3456-4043 236 µM -3.06900735901027 0.00107313182737074 no 3338 0.00107385650396979 4774 914281
SGTC_2568 diosmetin 100 µM -3.07159518280735 0.0010638255207671 no 3339 0.0010645913410892 4789 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1927 st060202 13.8 µM -3.07959606286125 0.00103551895383599 no 3340 0.00103640756113789 4781 688887
SGTC_181 1447-1644 8.07 µM -3.10707692950795 0.000943473949715408 yes 3341 0.000944736108882342 4772 534600
SGTC_2272 7805186 180 µM -3.14283447693526 0.000834954756090691 yes 3342 0.000836602137351258 4786 2956062 YPR165W RHO1
SGTC_2917 7979103 53.79 µM -3.25551873336871 0.000563640086277489 yes 3343 0.000565927146549826 4792 2980565
SGTC_1673 st016611 27.3 µM -3.30271266871956 0.000476405308629482 yes 3344 0.000478772241746228 4787 5226799
SGTC_306 1672-3436 11.6 µM -3.30508223862305 0.000472373897094085 yes 3345 0.000474742677120682 4800 6797378
SGTC_1922 5578187 25 µM -3.31737670249537 0.000451959641063239 yes 3346 0.000454335059048143 4795 1350412
SGTC_2922 7999257 32.47 µM -3.38162956399997 0.000357944881142282 yes 3347 0.000360286214645206 4786 2988377
SGTC_31 0508-1974 57.237 µM -3.41232263320364 0.000319766515901235 yes 3348 0.000322059142642405 4797 6810525
SGTC_2333 9017922 200 µM -3.44730988272114 0.000280880995279063 yes 3349 0.000283099373308312 4792 3163164
SGTC_650 1328-0195 38 µM -3.59303424246465 0.000161636238919572 yes 3350 0.000163424808079429 4805 2780821
SGTC_908 3448-7491 47.7 µM -3.67601421030691 0.000116936886854082 yes 3351 0.000118453166066001 4804 1203031
SGTC_2589 lobaric acid 100 µM -3.6815242733015 0.000114423432895391 yes 3352 0.000115921855726417 4782 73157 A novel microtubule depolymerizer.
SGTC_2787 5284540 71.43 µM -3.75996591107958 8.3715623900959e-05 yes 3353 8.49682558786499e-05 4794 736958
SGTC_1044 1222-0021 1.78 µM -4.44819374194498 4.18672969482485e-06 yes 3354 4.32977030840049e-06 4796 4306703
SGTC_909 3448-9333 149 µM -9.09898884255684 3.42998114620946e-20 yes 3355 4.55883552422697e-20 4810 3344074