SGTCid condition conc unit RPB2|YOR151C.score RPB2|YOR151C.strain.pval RPB2|YOR151C.strain.significant RPB2|YOR151C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1723 st034307 2.5525 µM 5.3283379591803 4.71455242050133e-07 yes 1 4.95577841633444e-08 8 867466
SGTC_526 4469-0568 170 µM 5.27393613779702 6.07167942226384e-07 yes 2 6.67641945266896e-08 4 2901964
SGTC_2163 5671233 125 µM 5.21718129897228 7.88525761053678e-07 yes 3 9.08332130056703e-08 7 701023
SGTC_2111 5486399 200 µM 4.18093951468925 5.89276778805764e-05 yes 4 1.45153543540532e-05 21 689674
SGTC_2969 9091408 28.7 µM 4.02426309870982 0.000104944620187418 yes 5 2.8576997040835e-05 5 4286311
SGTC_2109 5483026 200 µM 3.94618422083137 0.000138895919850511 yes 6 3.97032638045314e-05 36 759335
SGTC_1308 1187-1617 41.4 µM 3.80328298451012 0.000229098657643194 yes 7 7.13955421520347e-05 11 2882570
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.76982635407742 0.000256973032215769 yes 8 8.16805837034144e-05 15 16725076
SGTC_121 0557-0495 61.343 µM 3.70509362426424 0.000320090722280548 yes 9 0.000105656332841669 8 3104427
SGTC_3000 9075062 71.4286 µM 3.66772492708595 0.000362811143925244 yes 10 0.000122359123445396 10 17057871
SGTC_1133 3473-0247 50 µM 3.66029927818611 0.00037190750196091 yes 11 0.000125960416715789 56 711311
SGTC_1493 4348-0038 111 µM 3.62686288013539 0.000415551731640261 yes 12 0.000143442770448414 41 800424
SGTC_589 1227-0070 34.1 µM 3.53032167016967 0.000569655402694293 yes 13 0.000207527355071355 17 2841384
SGTC_2001 4023502 57.655 µM 3.5280842508472 0.000573784924052296 yes 14 0.000209289453663221 9 108941 YCR052W RSC6
SGTC_624 k048-0052 28 µM 3.44709983164031 0.000743255299993198 yes 15 0.000283319577849107 12 6835531
SGTC_682 0kpi-0099 17 µM 3.40102649731881 0.000859166747092628 yes 16 0.000335666600915267 42 1714895 YML126C ERG13
SGTC_77 0828-0286 12.516 µM 3.38756255577899 0.000896052284409751 yes 17 0.000352583171704319 10 745345
SGTC_1213 1315-0166 115 µM 3.21783528397789 0.00150374276948154 no 18 0.000645809844764029 27 768401
SGTC_1674 st016616 23.6 µM 3.17348480633943 0.00171518987617437 no 19 0.000753103924850103 17 625830
SGTC_1374 2889-5571 141 µM 3.12556340057389 0.0019737959844182 no 20 0.00088732405535414 54 2853281
SGTC_303 1348-1668 34.2 µM 3.12152958497896 0.00199710393717774 no 21 0.000899570847806598 13 5380509
SGTC_584 0986-0246 15.4 µM 3.11829005546603 0.00201600301720479 no 22 0.000909518435002442 43 53315 YDR232W HEM1
SGTC_623 k072-0108 16.9 µM 3.10188821478908 0.00211420493546769 no 23 0.00096145277906247 27 5382803
SGTC_191 3914-0123 66.505 µM 3.07694902261999 0.00227185375461421 no 24 0.00104565531246599 11 3144412
SGTC_2979 9012552 45.46 µM 3.04907779662157 0.00246057777776683 no 25 0.00114772515170879 5 17100905
SGTC_1316 1272-0050 65.9 µM 3.04784018033395 0.00246927774500648 no 26 0.00115246238538949 6 7340392
SGTC_2487 5918373 44.05 µM 3.01113880002972 0.0027402580752487 no 27 0.00130134925103343 10 2876279
SGTC_1747 st037496 66.6 µM 3.00214550754128 0.00281062733218661 no 28 0.00134042001019531 24 723305
SGTC_1738 st035555 74 µM 2.98521314220056 0.00294755618314556 no 29 0.00141690395198642 19 5331140
SGTC_1689 st020265 53.493 µM 2.98509958181848 0.0029484944771247 no 30 0.00141743009454153 15 5758320 YPR016C TIF6
SGTC_2984 9022109 38.96 µM 2.98486708328638 0.002950416338799 no 31 0.00141850785220825 12 6459207
SGTC_1175 0741-0056 27.6 µM 2.93514185445955 0.00338835170727446 no 32 0.0016669761722095 20 765927
SGTC_2897 9048598 12.99 µM 2.93099950322529 0.00342734654976518 no 33 0.00168936660893073 5 6467404
SGTC_254 nsc-64875 3.808 µM 2.90844923495191 0.00364678570057257 no 34 0.00181613071660428 10 56993
SGTC_767 0929-0023 86 µM 2.89275725537619 0.0038068402851844 no 35 0.00190938154475144 27 1204563
SGTC_2051 5263410 176 µM 2.82089065219854 0.00462321244632985 no 36 0.00239452620078112 14 227584
SGTC_2498 4'-Methoxychalcone 54.63 µM 2.81553951705504 0.00468983411150458 no 37 0.00243477038942295 12 641818 YHR062C RPP1
SGTC_2607 solasodine 47.35 µM 2.80580170883549 0.00481327034787216 no 38 0.002509578433732 37 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2904 7225135 42.03 µM 2.78895228213021 0.00503370854221099 no 39 0.00264394277666598 18 4446116
SGTC_3221 9128209 49.47 µM 2.77101779238432 0.00527817820608102 no 40 0.00279406866108767 22 16460723
SGTC_3317 9138495 8.753 µM 2.75830990476265 0.00545773928927898 no 41 0.00290505434531826 25 17020139
SGTC_1168 k815-0004 80.5 µM 2.75769731812504 0.00546653062346411 no 42 0.00291050349726963 42 642433
SGTC_1165 k072-0275 30.3 µM 2.75385854897003 0.0055219085270456 no 43 0.00294486086782543 26 6153523 YGL055W OLE1
SGTC_143 4032-1194 15.74 µM 2.74999844789125 0.0055780961798066 no 44 0.00297977734928264 50 1806963
SGTC_901 1112-0062 60.1 µM 2.7446718874739 0.00565646332040167 no 45 0.00302857123095681 18 1908457
SGTC_1292 0kpi-0043 232 µM 2.71843146237499 0.00605697024018269 no 46 0.00327961216177114 16 3333905
SGTC_2990 9074105 71.4286 µM 2.69049093640138 0.00651086467520013 no 47 0.00356734865395134 16 6502001
SGTC_709 3807-1509 243 µM 2.68850022514533 0.00654432335296984 no 48 0.00358868936415095 32 1886677 YPL242C IQG1
SGTC_1889 st059080 5.18 µM 2.67326859873477 0.00680539971662651 no 49 0.00375580397842212 17 176925 Isolated from Daphnopsis sellowiana.
SGTC_1822 st052468 42 µM 2.67257069048831 0.00681757957165975 no 50 0.00376362565963477 10 2873678
SGTC_538 2922-0838 53.3 µM 2.65815994641741 0.00707341532864491 no 51 0.00392842975495479 24 777039
SGTC_815 1582-0027 36.9 µM 2.65716040767173 0.00709147044217165 no 52 0.00394009690062145 24 3128206
SGTC_2446 5162541 200 µM 2.64323829432764 0.00734721254650311 no 53 0.00410586097776022 20 1549321
SGTC_1857 st056007 79.3 µM 2.6171084069944 0.00784922647475861 no 54 0.00443390864637195 9 619834
SGTC_1051 3253-3903 78 µM 2.6127279339275 0.00793627551156443 no 55 0.00449113872548645 28 5509239
SGTC_1287 0971-0001 34.6 µM 2.57552205862107 0.00871050856977762 no 56 0.00500444444108953 29 4665869
SGTC_804 1595-0054 20.9 µM 2.55500317745412 0.00916521425341626 no 57 0.00530934143201304 24 761523 Stimulates phospholipase C.
SGTC_351 caspofungin 25 nM 2.5481716143479 0.00932114804194681 no 58 0.0054144592553889 63 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1204 4049-0315 18.3 µM 2.53080045214487 0.00972815144879056 no 59 0.00569012859019662 32 588402
SGTC_524 r073-0010 27.8 µM 2.51001463682299 0.0102354934225429 no 60 0.00603630787334332 42 2772106
SGTC_757 1066-0008 322 µM 2.50370964890613 0.0103938796406347 no 61 0.00614494222269977 20 6842497
SGTC_2566 crystal violet carbinol 226 nM 2.4915878506701 0.0107043990636447 no 62 0.00635867563816541 59 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2313 7726885 200 µM 2.47649135063759 0.0111023912178104 no 63 0.00663404199165436 39 726423
SGTC_681 1642-0006 26.6 µM 2.47081530634707 0.011255325094945 no 64 0.00674027106004682 20 4446530
SGTC_1378 2093-0007 380 nM 2.46756232948805 0.0113437953082694 no 65 0.00680182678230162 32 3618014
SGTC_755 1995-0008 37.3 µM 2.45057103120358 0.0118157902229504 no 66 0.00713149090774803 17 689533
SGTC_627 1391-0720 175 µM 2.4450867806366 0.0119717297832848 no 67 0.00724086458779764 35 997839
SGTC_2171 5739187 198.077 µM 2.43841466883139 0.01216384905349 no 68 0.00737592052892615 25 2262761
SGTC_382 3229-0966 23.2 µM 2.4326960576984 0.0123306339247615 no 69 0.00749343770112202 21 5722370
SGTC_1387 3342-1166 1.8 µM 2.41768037655341 0.0127780320560938 no 70 0.00780989512961455 17 3418228
SGTC_2750 bromebric acid 70.15 µM 2.40617201240909 0.0131303703012482 no 71 0.00806033614717841 41 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2105 5350118 200 µM 2.4037159259937 0.0132066432213165 no 72 0.00811468966820405 39 2133313
SGTC_3356 9151811 4.48 µM 2.40289772128029 0.0132321371500665 no 73 0.00813286803631648 27 1859254 YPR165W RHO1
SGTC_2173 5763948 167 µM 2.38027847020608 0.0139539459080755 no 74 0.00864977965332099 26 2867177
SGTC_1812 st052057 4.327 µM 2.38013609307235 0.0139585947707264 no 75 0.00865312258285062 39 3645418
SGTC_1947 st076332 61.6 µM 2.36591931269048 0.0144295710268275 no 76 0.00899268184605087 23 24208416
SGTC_2481 5478948 45.16 µM 2.36248722861489 0.0145452986599037 no 77 0.009076383448685 37 77792
SGTC_771 0250-0039 27.3 µM 2.34083303701567 0.0152940405365342 no 78 0.00962038473229621 33 3005115
SGTC_88 0180-0332 8.668 µM 2.33994264357261 0.0153255237300698 no 79 0.00964335079126685 38 3101745
SGTC_1816 st051957 91.6 µM 2.3359295340552 0.0154681138833214 no 80 0.00974745720099269 19 674121
SGTC_1256 0570-0116 285 µM 2.32278509962853 0.01594315118168 no 81 0.0100953499654396 39 410638
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.29145113233436 0.0171262511307311 no 82 0.0109686675691754 31 442882
SGTC_2349 9023730 187.07 µM 2.2885118366145 0.0172409862202534 no 83 0.011053865800583 29 4126287
SGTC_1819 st053448 58.6 µM 2.27899234951146 0.0176170962988739 no 84 0.011333760042172 32 2857616
SGTC_194 1486-1323 56.904 µM 2.2738501860342 0.0178231579205987 no 85 0.0114874978123645 46 5178754
SGTC_596 1155-0152 116 µM 2.27136708181992 0.0179233971058525 no 86 0.0115623827140819 39 280313
SGTC_379 3970-0972 5.9 µM 2.25585330511635 0.0185606116768204 no 87 0.012039909853757 33 2898042 YBL034C STU1
SGTC_362 0310-0100 9.03 µM 2.22089847355732 0.0200673446903756 no 88 0.0131789193256222 31 790235
SGTC_1694 st024011 44.9 µM 2.21616913106669 0.0202789614762397 no 89 0.0133399605636934 35 2787533
SGTC_1993 st073995 70.8 µM 2.21382631491103 0.0203844907454175 no 90 0.0134203645594801 36 3098394
SGTC_197 4544-0043 41.561 µM 2.21251850933295 0.0204436014011971 no 91 0.0134654293643517 69 896523
SGTC_1719 st032227 49.2 µM 2.20610515990167 0.0207355811021916 no 92 0.0136883187617069 49 3125804
SGTC_3005 9076496 71.4286 µM 2.20609998451967 0.0207358181396603 no 93 0.0136884999044978 24 21368410
SGTC_1519 esterone 74 µM 2.20003962099247 0.0210149676763982 no 94 0.0139020420361787 38 698 A steroid.
SGTC_1289 0976-0073 69.1 µM 2.18614775331689 0.0216668673460624 no 95 0.0144023986280761 38 3391136
SGTC_166 k072-0058 166.424 µM 2.17884465750153 0.0220163761072937 no 96 0.0146716050917443 58 5846229
SGTC_2991 9074669 71.4286 µM 2.17707425460348 0.0221018164928162 no 97 0.0147375138071842 80 17333109
SGTC_95 0471-0001 561.058 µM 2.17677319434384 0.0221163735929219 no 98 0.0147487470048645 36 4015405
SGTC_528 3492-0019 172 µM 2.1752776416238 0.0221888077221489 no 99 0.0148046584797835 72 2869262
SGTC_2864 9034755 47.6 µM 2.17504464000565 0.0222001106974945 no 100 0.0148133856736227 31 4930451
SGTC_231 b-estradiol 524 µM 2.16166608696084 0.0228573056406879 no 101 0.0153219617260872 32 450 A steroid.
SGTC_2676 harmalol 100 µM 2.16118884087441 0.0228810490191229 no 102 0.0153403775340294 46 5459187 A monoamine oxidase inhibitor
SGTC_1597 7-benzyloxygramine 47.5 µM 2.15465184005375 0.0232083670877302 no 103 0.0155945445587886 95 260807
SGTC_2992 9074591 71.4286 µM 2.15289418860532 0.0232970449369854 no 104 0.0156634976633277 33 17741321
SGTC_1077 5-fluorocytosine 377 nM 2.13204535337562 0.0243708504882743 no 105 0.0165015591652426 63 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_140 0062-0056 502.533 µM 2.12627233613984 0.0246754291730977 no 106 0.0167402950415723 34 3758964
SGTC_1864 st057645 30.4 µM 2.12251190357843 0.0248755385703519 no 107 0.0168973870806778 38 688666
SGTC_1153 4055-0057 267 µM 2.10732711907574 0.0256974841014036 no 108 0.0175446170998141 56 882706
SGTC_2294 7971431 200 µM 2.10119597253033 0.0260357431556355 no 109 0.017811883405035 40 5741572
SGTC_1072 oxiconazole 14.9 nM 2.09396127541347 0.0264396678444677 no 110 0.0181317150072095 63 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_312 4092-0653 6.84 µM 2.08927541042841 0.026704071365828 no 111 0.0183414692796706 82 1148278
SGTC_2781 5567276 71.43 µM 2.07685369144514 0.0274156807580161 no 112 0.0189075324741911 50 2853274
SGTC_1836 st055642 81 µM 2.06712602867001 0.027983933605747 no 113 0.0193611400251682 54 8571
SGTC_1025 k007-0731 70 µM 2.0563197988867 0.0286266591815924 no 114 0.0198758505604736 41 6256118
SGTC_1659 st012954 42.1 µM 2.05543325060455 0.0286799292738588 no 115 0.0199185883281316 39 24207262
SGTC_1073 triclabendazole 3.09 µM 2.04862468911166 0.0290917893291087 no 116 0.0202494142642428 41 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1286 0929-0070 131 µM 2.04135267084415 0.0295370997856987 no 117 0.0206078926169639 45 1420408
SGTC_1471 k673-0312 37 µM 2.03791771435762 0.0297494026072566 no 118 0.0207790813582151 38 24099884
SGTC_752 1896-0090 130 µM 2.02984115449919 0.0302535786597021 no 119 0.0211863440924833 45 772567
SGTC_1905 st060207 84.5 µM 2.01716256942282 0.0310593041097024 no 120 0.0218392754043763 49 1948547
SGTC_1036 k216-0215 33.5 µM 2.01515736546529 0.031188346654426 no 121 0.0219440815626312 38 622330
SGTC_948 3448-0295 75.3 µM 2.00925800604587 0.0315705668389743 no 122 0.0222548894680329 52 678569
SGTC_1189 1431-2119 7.28 µM 2.0034577860415 0.0319501301261156 no 123 0.0225640871537384 71 3107275
SGTC_572 0960-0087 17.7 µM 1.99994377172477 0.0321819130958224 no 124 0.0227531679378079 76 6796365
SGTC_2715 st079500 56.4 µM 1.9951471680558 0.0325005338242505 no 125 0.0230134156088831 48 28246688
SGTC_2760 etidronate 98.04 µM 1.99459162381715 0.032537604158901 no 126 0.0230437189445698 44 3305 A chelator and antioxidant.
SGTC_839 0122-0028 230 µM 1.9856268164449 0.0331406451254933 no 127 0.0235373882770859 106 759448
SGTC_2560 caryophyllene 100 µM 1.98303930764059 0.0333164030593505 no 128 0.0236815195174495 53 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1448 4255-0083 152 µM 1.97712233698401 0.0337212023001562 no 129 0.0240139017400145 57 5399660
SGTC_1288 0973-0013 65.5 µM 1.97692757559035 0.0337345950589641 no 130 0.0240249086451955 39 4315430
SGTC_2170 morpholine 200 µM 1.97428637951655 0.0339166493039236 no 131 0.0241745943803772 42 121171 Reacts with secondary amines.
SGTC_2601 securinine 100 µM 1.97089628658642 0.0341515075682589 no 132 0.0243678699863799 80 442872 A GABA receptor antagonist.
SGTC_2653 dihydrofissinolide 100 µM 1.95215842356997 0.035473858906137 no 133 0.025459699321967 37 6857746
SGTC_2885 9057732 51.95 µM 1.95214575010876 0.03547476729386 no 134 0.0254604514285143 51 6471414
SGTC_1342 1486-1464 234 µM 1.95090890633951 0.0355635115698129 no 135 0.025533941495624 57 3253938
SGTC_12 0849-0099 9.267 µM 1.94939129782747 0.0356726494524739 no 136 0.0256243564838805 52 6071388
SGTC_1299 1079-1439 3.74 µM 1.94355998545359 0.0360945613175149 no 137 0.0259742675646638 57 323161
SGTC_2319 6033012 152.6 µM 1.94181170765008 0.0362218474376717 no 138 0.0260799495177267 48 847246
SGTC_2378 9074213 121.43 µM 1.94031631281792 0.0363310134017554 no 139 0.0261706300351362 75 657714
SGTC_2951 9072950 58.06 µM 1.94002555390744 0.0363522704585653 no 140 0.0261882921914389 53 16488155
SGTC_3301 9125354 19.7965 µM 1.93966770383952 0.0363784464476005 no 141 0.0262100434822568 42 41905162
SGTC_835 0312-0010 67.2 µM 1.93728408369868 0.036553197158348 no 142 0.0263553133839072 64 1626196
SGTC_171 k064-0041 9.68 µM 1.93454996030974 0.0367544894607118 no 143 0.0265227728137726 54 53325
SGTC_1180 1193-0155 285 µM 1.93453735074551 0.0367554199010114 no 144 0.0265235471783247 51 2921347
SGTC_2071 5230951 39.92 µM 1.93287387840338 0.0368783339572477 no 145 0.0266258682416848 58 1799272
SGTC_2492 derrusnin 100 µM 1.92637411361628 0.0373618279005349 no 146 0.0270288386563362 61 1715307 Part of coumarin class of compounds.
SGTC_1429 4049-0205 9.46 µM 1.92047559646406 0.0378050670692961 no 147 0.0273989263775824 49 22774478
SGTC_2694 st077685 81.9 µM 1.91304595623093 0.0383694584426062 no 148 0.0278710847176984 50 2838096
SGTC_812 4251-0442 148 µM 1.90903952783295 0.0386766454226346 no 149 0.0281284963560538 57 5723007
SGTC_6 0844-0013 19.835 µM 1.90605562861972 0.0389067309579145 no 150 0.0283214943411924 86 1584900
SGTC_2894 9048625 32.47 µM 1.90390446416366 0.0390732956277208 no 151 0.0284613138079212 72 4092861
SGTC_1425 4048-4433 7.33 µM 1.90031554875025 0.0393524771890775 no 152 0.0286958610335178 56 23734946
SGTC_13 0199-0087 65 µM 1.89998948849063 0.0393779216267378 no 153 0.0287172495441415 63 4589825
SGTC_1986 st071812 45 µM 1.89932797302882 0.0394295847719655 no 154 0.0287606835736888 40 11838594
SGTC_1065 prochlorperazine maleate 2.48 µM 1.89675253700969 0.0396312470865288 no 155 0.0289303031100964 66 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_772 k072-0172 35.3 µM 1.88701419152852 0.0404013753149476 no 156 0.0295792084431457 41 5861980
SGTC_2339 9000433 200 µM 1.88567186307361 0.0405084760096034 no 157 0.0296695933856616 55 2988954
SGTC_2036 5160441 105 µM 1.8788932597184 0.0410528481053729 no 158 0.0301295346890086 86 134534 YIL048W NEO1
SGTC_2005 4024620 188 µM 1.8771903809065 0.0411905302486496 no 159 0.030246002711386 57 236743
SGTC_2783 7738165 71.43 µM 1.86792880068857 0.0419459214114526 no 160 0.0308859979120752 56 17201110
SGTC_905 2-aminofluorene 215 µM 1.8620605962464 0.0424303198996633 no 161 0.0312972746798431 46 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2985 9022375 71.43 µM 1.8552689522169 0.0429965828228062 no 162 0.0317789147676323 63 4939335
SGTC_3051 9093778 49.47 µM 1.85046708095262 0.0434006183053968 no 163 0.0321231292053491 56 17217378
SGTC_1992 st073643 23.3 µM 1.84787707382639 0.0436198140063466 no 164 0.0323100639063323 64 3161292
SGTC_7 0192-1582 4.227 µM 1.83776923458135 0.0444838141262734 no 165 0.0330482084339623 83 252616
SGTC_531 3788-1495 174 µM 1.83684851608458 0.0445631959261021 no 166 0.0331161307023251 51 2896655
SGTC_1290 0986-0249 10.2 µM 1.83550098597823 0.0446795819214138 no 167 0.0332157465667192 54 53329
SGTC_1726 st035556 14.5795 µM 1.83102541433347 0.0450678942100058 no 168 0.0335483749235111 51 5919439
SGTC_1899 st063254 59.6 µM 1.82891967119019 0.045251531206393 no 169 0.0337058214471443 65 3093813
SGTC_2414 st077232 92.9 µM 1.82099352168687 0.0459481561201919 no 170 0.0343039208189036 57 729801
SGTC_1436 4092-1007 8.32 µM 1.81574392354054 0.0464142651099419 no 171 0.0347048314424842 56 2881121
SGTC_877 0771-0151 33.1 µM 1.81537238772095 0.0464473968795675 no 172 0.0347333507424561 61 6166523
SGTC_2956 9076196 2.52 µM 1.81376399090185 0.046591044977389 no 173 0.0348570342636257 56 16423868
SGTC_1547 harmine 94.2 µM 1.80995108768113 0.0469330050545135 no 174 0.0351516863100201 87 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1669 st015249 58.4 µM 1.80817135469326 0.0470933079079385 no 175 0.0352899177167218 49 722793
SGTC_607 4491-0986 66.8 µM 1.80706683367215 0.0471930140979686 no 176 0.0353759295808873 50 698981 YDR232W HEM1
SGTC_2580 diallyl disulphide 81.36 µM 1.80666301340777 0.0472295095616511 no 177 0.0354074189797465 85 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1868 st057644 42.7 µM 1.80603785876172 0.047286052847637 no 178 0.0354562130896798 75 688665
SGTC_1728 st035614 33.7865 µM 1.8012651286941 0.0477195215572082 no 179 0.035830550669928 78 15945546
SGTC_2259 7964009 200 µM 1.79884351858539 0.0479406706399735 no 180 0.0360217185819215 49 313134
SGTC_1683 st010134 710 nM 1.78931633652843 0.0488186968837807 no 181 0.0367819422771068 63 3818134
SGTC_320 4092-0846 5.34 µM 1.78413112753481 0.049301939641606 no 182 0.0372011801618116 91 1359356
SGTC_870 0573-2213 57.6 µM 1.77971437977388 0.0497165701158827 no 183 0.0375613579582127 61 3916321
SGTC_1645 Cervolide 78 µM 1.77846654630793 0.0498342154969592 no 184 0.0376636308109604 67 23173 A fragrance.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.77548714408789 0.0501160108215384 no 185 0.0379087432089696 54 279621
SGTC_1943 st076331 65.2 µM 1.77494205584936 0.0501677031082633 no 186 0.0379537276080508 56 24208415
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.77303817733104 0.05034858695598 no 187 0.0381111904858705 67 5379071
SGTC_1826 st055655 41.6 µM 1.77226376349774 0.0504223110666098 no 188 0.0381753917042203 72 676168
SGTC_1336 1486-0901 104 µM 1.77107938482488 0.0505352301302572 no 189 0.0382737508072277 49 5006114
SGTC_1557 sumaresinolic acid 42.3 µM 1.76894226144229 0.0507394938304413 no 190 0.0384517552849471 47 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_481 bay k-8644 50 µM 1.76423228470174 0.0511919889960869 no 191 0.0388464396537408 64 2303 A calcium channel antagonist.
SGTC_3156 9099931 49.47 µM 1.75775090031622 0.0518199088498217 no 192 0.0393949514885972 60 18111053
SGTC_3120 9124077 49.47 µM 1.75604166991072 0.0519865158964803 no 193 0.0395406468586464 52 18774327 YGL155W CDC43
SGTC_2059 5238311 157 µM 1.74627310138322 0.0529468877916705 no 194 0.0403817537951939 70 703021
SGTC_1651 st011928 86.1 µM 1.7447314655504 0.053099727242039 no 195 0.040515811711717 76 720198
SGTC_1219 1469-0211 33.1 µM 1.74094838123577 0.053476268979765 no 196 0.0408463135081116 62 6822282
SGTC_799 1310-0557 151 µM 1.73979786817816 0.0535912016048774 no 197 0.0409472584795397 81 5354492
SGTC_2146 5545642 200 µM 1.73906994816138 0.053664019531056 no 198 0.0410112299702307 73 825326
SGTC_2044 5102272 200 µM 1.73231347705757 0.0543436527435633 no 199 0.0416088818484631 75 592666
SGTC_2796 7949634 45.45 µM 1.72539132504862 0.0550469954090161 no 200 0.0422284868059385 85 2971588
SGTC_1163 k060-0048 49.9 µM 1.72477278793233 0.0551101918826146 no 201 0.0422842137991691 68 6809982
SGTC_2600 tangeritin 87.95 µM 1.71958666805428 0.055642319763839 no 202 0.0427538006388919 85 68077 A bioactive flavone.
SGTC_1440 4100-1550 40 µM 1.71497668295045 0.0561187297136872 no 203 0.04317475100053 64 742806
SGTC_1662 st014054 52 µM 1.71166865699528 0.0564625691433589 no 204 0.0434788739217703 54 2838777
SGTC_1670 st016595 4.04 µM 1.7113030822481 0.0565006689962614 no 205 0.0435125888361122 70 597879
SGTC_44 0929-0055 61.211 µM 1.70873787279101 0.0567685828192888 no 206 0.043749757699589 82 1379590
SGTC_2166 5933061 31.504 µM 1.70684156744533 0.0569672779165726 no 207 0.0439257519993928 53 2877375
SGTC_2712 st079126 47.7 µM 1.70193794610115 0.0574836190315052 no 208 0.0443835007320058 61 3152970
SGTC_574 1315-0397 40 µM 1.69948662502658 0.057743114604097 no 209 0.0446137662740977 94 6794277
SGTC_54 0159-0055 9 µM 1.69674948603502 0.0580339541762152 no 210 0.0448720162667967 74 3319099
SGTC_1879 gemcitabine 100 µM 1.69523812384978 0.0581950392797919 no 211 0.045015128731092 67 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1447 4239-0816 81.9 µM 1.69468318282037 0.0582542745030224 no 212 0.0450677687969145 88 1341554
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.68556696901367 0.0592341475283056 no 213 0.0459396178924463 73 688751
SGTC_3077 9117319 49.47 µM 1.67451122808879 0.0604397832504071 no 214 0.0470150847959132 79 17154678
SGTC_2396 5342950 42.78 µM 1.6703809816241 0.0608950849207803 no 215 0.0474220050043539 131 1886677
SGTC_1131 3454-3128 32.3 µM 1.66991019262319 0.0609471526034136 no 216 0.0474685667062171 85 710982
SGTC_1373 2887-0003 58.5 µM 1.66965943535142 0.0609748997183781 no 217 0.0474933819029123 100 776948
SGTC_3203 9113543 49.47 µM 1.66811112657055 0.0611464439569385 no 218 0.0476468344085627 97 17018012
SGTC_2882 9058044 58.44 µM 1.66770458433208 0.0611915490989597 no 219 0.0476871924635685 78 18076804
SGTC_1745 st081495 74 µM 1.66679628764721 0.0612924169446501 no 220 0.0477774593412914 108 13842402 YBL026W LSM2
SGTC_1121 fusaric acid 630.51 nM 1.66651342761629 0.0613238555309754 no 221 0.0478055980018226 68 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_787 4152-0075 138 µM 1.65820846311135 0.0622525408871511 no 222 0.0486376985847099 75 9566539
SGTC_2512 diallyl trisulfide 49.23 µM 1.6571148783922 0.0623756417498754 no 223 0.048748125815472 83 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2271 7849410 118.62 µM 1.65627624828269 0.0624701718333341 no 224 0.0488329441019284 70 972430
SGTC_1472 k841-0093 193 µM 1.65614059543757 0.0624854730626082 no 225 0.0488466749819512 63 X1472
SGTC_1652 st011932 78 µM 1.65497343988564 0.0626172454208809 no 226 0.0489649428312939 97 1551076
SGTC_2147 5545932 89.7195 µM 1.65417549649037 0.0627074581627984 no 227 0.0490459300087544 95 797404
SGTC_2470 5664817 21.68 µM 1.65053659608411 0.0631201445587699 no 228 0.0494166173637414 69 2859561
SGTC_555 4296-0685 37 µM 1.64803071778793 0.0634055629515759 no 229 0.04967318394209 86 2908540 YHR072W ERG7
SGTC_523 1934-0222 13.7 µM 1.64715101494529 0.0635059985987337 no 230 0.0497635047497714 93 1361595
SGTC_203 k066-0004 30.888 µM 1.64059468617339 0.0642584389783666 no 231 0.0504407893901137 101 6795412
SGTC_1588 farnesol 29.9 µM 1.63986237327677 0.0643429116369463 no 232 0.0505168929137675 75 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1574 spiramycin 23.7 µM 1.63812862195181 0.0645432446968145 no 233 0.0506974327211985 86 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_860 0443-0016 25.1 µM 1.63686584591763 0.0646894618058986 no 234 0.0508292518519146 104 5337942
SGTC_428 3448-4153 16.5 µM 1.63531145553978 0.0648697980693009 no 235 0.0509918866698865 88 3834874
SGTC_363 0455-0021 3.06 µM 1.63118042075589 0.0653509669283463 no 236 0.0514261276843449 105 4597466
SGTC_2656 pseudo-anisatin 100 µM 1.6306371998668 0.0654144448788001 no 237 0.0514834474631817 56 6708809 A neurotoxin.
SGTC_149 3970-0822 46.1 µM 1.62619858464137 0.0659349114879704 no 238 0.0519537085890604 99 3114250 YBL034C STU1
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.6253784044772 0.0660314351250932 no 239 0.0520409772508443 97 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1018 4259-0013 28.1 µM 1.6181449937441 0.0668874522004513 no 240 0.0528156769485701 82 6801262
SGTC_332 4112-0506 40.9 µM 1.61349892648017 0.0674417893778514 no 241 0.0533180781483716 117 2790355
SGTC_1980 st071811 45.7 µM 1.6097338951535 0.06789360636687 no 242 0.0537279809830921 92 4974850
SGTC_1111 tnp00062 510.699 nM 1.60321042449251 0.0686819748664242 no 243 0.0544441023738967 72 676306
SGTC_1056 3448-1962 115 µM 1.59425830485068 0.0697753160321928 no 244 0.0554390961606798 96 715507
SGTC_168 3970-0862 530.542 µM 1.59330522929818 0.069892501773111 no 245 0.0555458670741524 151 3135186
SGTC_298 1391-0729 10 µM 1.59259974678714 0.069979342127277 no 246 0.0556250051929905 77 3237558
SGTC_729 4092-0585 94.1 µM 1.58823205244953 0.0705188263242828 no 247 0.0561169378607216 79 2169061
SGTC_553 k007-0256 45.7 µM 1.58334203913974 0.0711266128362726 no 248 0.0566717630017926 100 6287000
SGTC_3279 9140807 49.47 µM 1.57389296408258 0.072312437113013 no 249 0.0577560984057473 69 45595718
SGTC_3052 9092717 49.47 µM 1.57354295585087 0.0723566510875581 no 250 0.0577965750061356 86 25237534
SGTC_907 3448-6986 75.5 µM 1.57115865839063 0.0726583932676853 no 251 0.0580729001083768 105 590582
SGTC_1049 3226-0134 66 µM 1.57079883733929 0.0727040135972274 no 252 0.0581146911160879 92 5702385
SGTC_387 norethindrone acetate 66.7 µM 1.56721713636563 0.0731593202924325 no 253 0.0585319731425357 86 541197
SGTC_330 1488-0319 80.1 µM 1.5643065942436 0.0735309132969965 no 254 0.0588727921303406 108 6846614
SGTC_1627 st003713 25.6 µM 1.5633501289665 0.0736533411101276 no 255 0.0589851317313879 87 16195070 YER133W GLC7
SGTC_3355 9151058 44.0485 µM 1.55236945062998 0.0750700566068638 no 256 0.0602869243951551 87 17015728
SGTC_138 0850-0259 40.9225 µM 1.55098414445739 0.0752502536945111 no 257 0.0604527418634484 134 6813004
SGTC_1978 st071761 42 µM 1.54671162503096 0.0758080891410941 no 258 0.0609663993155122 106 5147680
SGTC_2464 5717415 7.67 µM 1.54219226004149 0.0764015755320696 no 259 0.0615134401865967 84 5285744
SGTC_2853 9015042 58.44 µM 1.54120785720065 0.0765313156712518 no 260 0.0616331029152845 71 6457456
SGTC_711 k292-0785 179 µM 1.53317426858349 0.0775963805228819 no 261 0.0626164612233427 92 4146315
SGTC_1314 1222-0010 41.1 µM 1.53270061632798 0.0776595252370556 no 262 0.0626748186303964 81 3526027
SGTC_3245 9134821 49.47 µM 1.53250666657276 0.0776853928063297 no 263 0.0626987268816428 108 17014901
SGTC_3267 9137951 49.47 µM 1.52550838566704 0.0786231534926154 no 264 0.0635661717889957 81 16643986
SGTC_1102 cgs 12066b 26.1 µM 1.51716519362976 0.0797523122370004 no 265 0.0646124908480086 86 6438352 A 5-HT1B full agonist.
SGTC_172 1112-0046 2.638 µM 1.51548491690853 0.0799811958180274 no 266 0.0648248235846793 90 2802135 YIL048W NEO1
SGTC_3036 9090181 49.47 µM 1.51341716859353 0.0802635411891512 no 267 0.0650868633427142 91 25236586
SGTC_2072 5231554 129 µM 1.5133871792351 0.0802676416884885 no 268 0.0650906698460058 99 789545
SGTC_1632 st005650 90 µM 1.5112063577988 0.0805662539058964 no 269 0.0653679415355756 100 2759605
SGTC_209 4077-0173 175.592 µM 1.50941437298811 0.0808122515044439 no 270 0.0655964611520634 71 15993494
SGTC_2826 7992541 19.48 µM 1.50811497956761 0.0809909822292884 no 271 0.0657625510120879 99 2985066
SGTC_3070 9117005 49.47 µM 1.50566891629239 0.081328245894285 no 272 0.0660760936312068 55 8779016
SGTC_2540 epiandrosterone 100 µM 1.50566629545075 0.0813286078237341 no 273 0.0660764301973803 97 441302 A steroid.
SGTC_909 3448-9333 149 µM 1.5014877815884 0.0819071931213467 no 274 0.0666147223005843 95 3344074
SGTC_1480 1070-0044 41.2 µM 1.49747324018793 0.0824659901788864 no 275 0.0671350817398733 86 3124987
SGTC_837 0091-0265 12.5 µM 1.49713324630521 0.0825134465405584 no 276 0.067179295258655 113 759367
SGTC_1771 st048882 4.1505 µM 1.4914225656271 0.0833136191840983 no 277 0.0679252936288953 104 4580403
SGTC_2769 toremifene 3.73 µM 1.48815335134696 0.0837743149496691 no 278 0.0683552281338126 98 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2265 7929201 200 µM 1.48247942349084 0.0845784200179636 no 279 0.0691063873236841 105 1265108
SGTC_2180 6301957 200 µM 1.48209814991153 0.084632660717133 no 280 0.0691570905033447 96 845462
SGTC_665 3914-0008 307 µM 1.48137208983371 0.0847360235349759 no 281 0.0692537239358509 84 1069549
SGTC_1554 st069299 38.7 µM 1.48074674067931 0.0848251248755726 no 282 0.0693370368135359 88 24207999
SGTC_3350 9150499 3.57 µM 1.4786792668778 0.0851202038645286 no 283 0.0696130280593416 113 4910996 YPR165W RHO1
SGTC_873 0591-4978 488 µM 1.47862781108943 0.0851275576602264 no 284 0.0696199077678522 104 3305145
SGTC_2365 9042475 200 µM 1.47823603782749 0.0851835634856247 no 285 0.0696723055495171 93 6464479
SGTC_1104 tacrolimus 29.8 µM 1.47513407951668 0.0856279780689321 no 286 0.0700882498936046 114 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2680 butyl paraben 22.24 µM 1.47445943234695 0.0857248635513863 no 287 0.0701789663334726 110 7184 An antifungal and steroid mimetic.
SGTC_3191 9110352 49.47 µM 1.47426796098693 0.0857523755286544 no 288 0.070204728977968 84 17122424
SGTC_2018 5133068 143 µM 1.47424647121697 0.0857554637453127 no 289 0.0702076208998829 94 785362
SGTC_1214 0358-0031 63.7 µM 1.47051208007662 0.0862933846833986 no 290 0.0707115581967714 105 4301366
SGTC_3171 9103192 49.47 µM 1.46868335998055 0.0865577216028184 no 291 0.0709593464339663 84 13018434
SGTC_3115 9123671 49.47 µM 1.46772353669159 0.0866967036533024 no 292 0.0710896673537064 84 3286988
SGTC_1479 0549-0158 134 µM 1.46683901181691 0.086824930124103 no 293 0.0712099272221365 94 5440202
SGTC_3121 9125696 49.47 µM 1.46519011645659 0.0870643429133117 no 294 0.0714345276865313 74 1235365
SGTC_2333 9017922 200 µM 1.46383102106123 0.0872620483532823 no 295 0.0716200621327754 84 3163164
SGTC_2635 hydroquinidine 100 µM 1.46374327391724 0.0872748243000896 no 296 0.07163205346861 68 442912 An experimental heart treatment.
SGTC_2849 9019321 12.99 µM 1.46225090197165 0.0874923269239802 no 297 0.0718362337581783 93 16489627
SGTC_227 fluconazole 33.516 µM 1.45887305216416 0.0879861182196561 no 298 0.0723000256745475 161 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_289 k017-0060 526 µM 1.45686090106174 0.0882812507102221 no 299 0.0725773903684964 92 5512909
SGTC_1964 st076914 61 µM 1.45602058314181 0.0884047226064199 no 300 0.072693464839728 127 24208661
SGTC_212 3807-4682 38.772 µM 1.4559958306056 0.0884083615639309 no 301 0.0726968861016792 114 3125501 YBL034C STU1
SGTC_2419 paclitaxel 166.5 µM 1.45408293998497 0.0886899200675167 no 302 0.0729616563921506 110 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2417 cerulenin 830 nM 1.45301457178101 0.0888474636287866 no 303 0.0731098541001608 103 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1904 st060225 78 µM 1.44677760547196 0.0897713391729497 no 304 0.0739796104320009 88 66595
SGTC_2922 7999257 32.47 µM 1.44454446482126 0.0901038624254706 no 305 0.0742929407666198 101 2988377
SGTC_2714 st079313 56.9 µM 1.4408045366602 0.0906628003033475 no 306 0.074819955719319 87 2939799
SGTC_2528 xanthyletin 44.79 µM 1.44047100413153 0.0907127719499801 no 307 0.0748670938987771 98 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2011 4012611 177 µM 1.43665514309661 0.0912859403107758 no 308 0.0754080033396508 95 2049887
SGTC_1594 piperine 70.1 µM 1.42541868017348 0.0929893233469594 no 309 0.0770181057187269 89 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_339 3091-4833 71.4 µM 1.42173335505074 0.0935530828540108 no 310 0.0775518365967572 131 3240077
SGTC_1190 1486-1332 13 µM 1.41934729594251 0.0939194319440106 no 311 0.077898894861363 112 4150046
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.41683187893312 0.0943067875762309 no 312 0.0782660434251204 100 4213774
SGTC_260 nsc-65238 3.989 µM 1.40800777865161 0.0956749502240438 no 313 0.0795643833334503 108 3246252
SGTC_750 4073-0104 132 µM 1.4068479599645 0.0958558586580839 no 314 0.0797362388125442 74 22330957
SGTC_2242 6630449 61.2675 µM 1.40376018041412 0.0963387166656475 no 315 0.0801951375676904 100 691249 YDR170C SEC7
SGTC_204 PMA1.184 62.41 µM 1.4016483845265 0.0966699809789935 no 316 0.0805101354735051 110 2252213 YGL008C PMA1
SGTC_3023 9089636 49.47 µM 1.40118030365105 0.09674351905919 no 317 0.080580081331493 98 17249241
SGTC_62 0180-0423 3.232 µM 1.39788518796738 0.0972623627323032 no 318 0.0810737736580368 133 30102 YGL099W LSG1
SGTC_2975 9084847 53.72 µM 1.39457097033758 0.0977862707217581 no 319 0.0815726270966812 109 27211724
SGTC_2787 5284540 71.43 µM 1.3941659949202 0.0978504303729215 no 320 0.0816337420216795 114 736958
SGTC_3140 9094243 49.47 µM 1.39335459974821 0.0979790713326091 no 321 0.0817562937006254 121 19291112
SGTC_2912 7964298 10.93 µM 1.39302662312025 0.0980311048624953 no 322 0.0818058700444406 144 2975850
SGTC_2655 perillic acid 100 µM 1.39012592171368 0.0984921831692604 no 323 0.0822453215562339 106 5702197 An apoptosis inducer.
SGTC_1682 st012968 530 nM 1.38625484456771 0.09910997730287 no 324 0.0828345499391074 91 24207270
SGTC_279 1273-0055 2.93 µM 1.38622114835491 0.0991153673733816 no 325 0.0828396928488999 134 2847562
SGTC_818 4072-2707 53.5 µM 1.38288452647848 0.0996501580213068 no 326 0.083350137786615 101 882871
SGTC_1442 4112-3290 3 µM 1.38067262512107 0.100005839754601 no 327 0.0836898209814175 102 704353
SGTC_2883 9059145 45.46 µM 1.37866218254244 0.100329929633432 no 328 0.0839994672916991 132 16476510
SGTC_1021 4476-0760 85.3 µM 1.37776661408593 0.100474544696878 no 329 0.0841376784566728 101 746768
SGTC_1735 st034310 56.75 µM 1.37008173498283 0.101721743529841 no 330 0.0853306943649717 125 871153
SGTC_2800 7887935 81.82 µM 1.36881544899575 0.101928329310997 no 331 0.085528485238374 119 2961002
SGTC_420 mitomycin C 81.9 mM 1.36695047453473 0.102233142719184 no 332 0.0858204147377592 125 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_688 0527-0193 473 µM 1.36559115737265 0.102455728341365 no 333 0.086033661782524 116 4007154
SGTC_2795 7780010 54.55 µM 1.36499218361017 0.102553920930554 no 334 0.086127753366155 124 953673
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.3637699288476 0.102754503110661 no 335 0.0863199936917537 110 61125 An anti-inflammatory.
SGTC_2950 9072895 21.46 µM 1.36078115112292 0.103246187043055 no 336 0.0867914301165778 114 17332245
SGTC_148 3253-0744 288.01 µM 1.36075526753666 0.103250452601071 no 337 0.0867955212638598 108 6893655
SGTC_321 4534-3890 65.3 µM 1.35944114735185 0.103467184906128 no 338 0.0870034198970965 124 699746
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.35922569200121 0.103502750533367 no 339 0.0870375411858802 127 688803
SGTC_396 dithiazanine 1.25 µM 1.35318092039943 0.104504191677677 no 340 0.0879989195205759 98 10578 An antihelmenthic.
SGTC_1817 st052116 64.4 µM 1.35173640182644 0.1047445417771 no 341 0.0882298278296769 92 4361398
SGTC_806 3966-4455 5.86 µM 1.35136412116337 0.104806549523051 no 342 0.0882894105412264 99 714982
SGTC_1384 3089-0840 101 µM 1.34635876425995 0.10564283333515 no 343 0.0890934213597459 80 1069836
SGTC_1518 st038567 90.8 µM 1.34585507059866 0.105727255784344 no 344 0.0891746305017561 119 77966
SGTC_3278 9139605 49.47 µM 1.34518520765316 0.105839604871689 no 345 0.0892827159813788 117 7958859
SGTC_317 4495-0002 170 µM 1.34313375765076 0.106184209803184 no 346 0.0896143332143981 107 15991618
SGTC_2817 7995342 71.43 µM 1.34215712388322 0.106348550339028 no 347 0.0897725276428851 107 18879975
SGTC_2710 st078562 53.7235 µM 1.33947771541397 0.10680036394193 no 348 0.0902076021763615 122 17250908
SGTC_76 0433-0009 400.328 µM 1.33877339073846 0.106919359819354 no 349 0.0903222279060464 118 2841569
SGTC_2293 7624732 200 µM 1.33800109245422 0.107049949767708 no 350 0.090448040334681 113 894453
SGTC_1416 3966-0321 25.3 µM 1.33677926221427 0.107256787164059 no 351 0.0906473501515751 124 582530 YLR208W SEC13
SGTC_3295 9122362 53.5725 µM 1.33620044635796 0.107354872461422 no 352 0.0907418826148281 135 4730473
SGTC_1157 4092-0394 27.6 µM 1.33544163154752 0.107483558047824 no 353 0.0908659233867857 114 3659885
SGTC_1839 st053978 48 µM 1.33509694906727 0.107542048628456 no 354 0.0909223089456936 103 3788398
SGTC_3227 9130768 49.47 µM 1.33384112371662 0.107755348792676 no 355 0.0911279651778494 100 17720899
SGTC_2099 5377090 177.372 µM 1.33198120324354 0.108071813311701 no 356 0.0914331826369635 134 2243829
SGTC_1412 3909-8563 178 µM 1.33109755140012 0.108222400475435 no 357 0.0915784572854112 131 23767530
SGTC_1782 st039423 80.636 µM 1.32969763615829 0.1084612755107 no 358 0.0918089569997491 109 2068169
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.32735700021988 0.108861517701196 no 359 0.0921953083401676 130 7104
SGTC_2628 lathosterol 100 µM 1.32671146147518 0.108972089600659 no 360 0.0923020740479025 117 6710616
SGTC_1720 st037298 9.481 µM 1.32459160918073 0.109335758892969 no 361 0.0926533202137508 128 597396
SGTC_610 4215-0184 155 µM 1.32434037225544 0.109378917329165 no 362 0.0926950140292266 126 5605015
SGTC_820 1582-0060 59.9 µM 1.32365209133472 0.10949721552749 no 363 0.0928093081965943 129 3848840
SGTC_2409 alverine citrate 63.97 µM 1.32224664300805 0.109739062097113 no 364 0.0930430169365605 99 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_997 3996-0078 137 µM 1.31924836575213 0.110256280314537 no 365 0.0935430468458099 131 735687
SGTC_929 2805-0021 398 µM 1.31586750749711 0.110841590204263 no 366 0.094109258093083 139 3098024
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.31567554870036 0.110874889662713 no 367 0.0941414822008099 116 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_82 0054-0107 293.755 µM 1.3115637595928 0.111589891163648 no 368 0.0948336837704486 114 3104697
SGTC_307 1501-1223 22.3 µM 1.31108890231048 0.1116726764002 no 369 0.094913864836356 112 2830329
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.30715123958055 0.112360850167202 no 370 0.0955806759770126 124 688669
SGTC_1936 st074407 74.3 µM 1.30658272574406 0.112460457449423 no 371 0.0956772332633128 146 809813
SGTC_2343 7990716 14.84 µM 1.30598672240131 0.112564948784123 no 372 0.0957785364494021 126 6456862
SGTC_3130 9127414 49.47 µM 1.30393773496115 0.112924706309625 no 373 0.0961274064630508 124 1494646
SGTC_397 arbidol 50 µM 1.30331406043586 0.113034372709608 no 374 0.0962337813874035 111 131410 A RNA synthesis inhibitor.
SGTC_1570 verbenone 133 µM 1.30304000520231 0.11308258637958 no 375 0.096280552041075 125 29025 A natural terpanoid with antifungal properties.
SGTC_2626 ethyl orsellinate 100 µM 1.30112048512459 0.1134206928665 no 376 0.0966086084478226 147 75653 A natural product.
SGTC_1439 4092-1168 46 µM 1.29676448646632 0.114190636402628 no 377 0.0973561167378016 119 2886240
SGTC_3290 9121031 71.43 µM 1.29225824217218 0.114991046259903 no 378 0.0981338639390095 112 17014854
SGTC_554 4483-2211 187 µM 1.29144800631127 0.115135384465528 no 379 0.0982741866192522 112 747107
SGTC_2806 7952793 58.44 µM 1.28418865656006 0.116434339409368 no 380 0.0995379766210787 120 2972490
SGTC_666 0272-0154 136 µM 1.28376573201543 0.116510334776302 no 381 0.0996119685882492 144 6870312
SGTC_2962 9082311 13.18 µM 1.28053956657406 0.117091202755186 no 382 0.100177719320669 142 16459453
SGTC_1697 st025554 27.742 µM 1.2785728959052 0.117446304976606 no 383 0.100523749803306 121 1269519
SGTC_2062 5245942 200 µM 1.27118578943414 0.118786930744556 no 384 0.101831280417718 118 1376160
SGTC_1777 st045864 34.765 µM 1.27101294947993 0.118818426952556 no 385 0.101862020908704 157 4691462
SGTC_2451 5856223 45.7 µM 1.2706870744908 0.118877826410242 no 386 0.101919997853727 152 2179896
SGTC_1995 st072814 61.1 µM 1.26964675609709 0.119067592676766 no 387 0.102105243283112 120 5769371
SGTC_2189 6047310 154.431 µM 1.26367496994441 0.120161054183458 no 388 0.103173356309282 113 711535
SGTC_3092 9117248 49.47 µM 1.2630246311834 0.120280560073773 no 389 0.103290163953569 142 17141857
SGTC_2966 9084041 48.03 µM 1.26273124195691 0.12033450051423 no 390 0.103342891144166 121 17741380
SGTC_2558 carylophyllene oxide 100 µM 1.26073295376645 0.120702344750358 no 391 0.103702538437401 126 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2606 farnesol 9.78 µM 1.2581705578463 0.121175187056284 no 392 0.104165040154996 155 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2197 6588183 93.1375 µM 1.25745109275595 0.121308184850201 no 393 0.104295169048671 122 884136
SGTC_1237 0330-0133 46.1 µM 1.25540055752751 0.121687802672032 no 394 0.104666693532094 150 X1237 YHR072W ERG7
SGTC_3046 9092212 49.47 µM 1.25189328479529 0.12233904140521 no 395 0.105304376008379 126 25236637
SGTC_1182 1222-0449 220 µM 1.25142756064225 0.122425701811823 no 396 0.105389263612549 116 658318
SGTC_2534 helenine 20.12 µM 1.24992088882927 0.122706353397567 no 397 0.105664223964294 138 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3099 9120367 49.47 µM 1.24857699299176 0.122957064802463 no 398 0.105909915804117 140 24824940
SGTC_1344 1488-0097 29.1 µM 1.24819539281367 0.123028319906157 no 399 0.105979755379605 144 747966
SGTC_112 phenothiazine 287.218 µM 1.2438197935163 0.123847432316407 no 400 0.106782946921305 129 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_409 arachidonic acid 100 µM 1.24226384116091 0.124139624699515 no 401 0.107069615888687 129 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3104 9120930 49.47 µM 1.24195477051491 0.124197722462423 no 402 0.107126625141443 137 17014836
SGTC_2291 7917025 104.35 µM 1.24095209810404 0.124386331417084 no 403 0.107311722564948 120 2964612
SGTC_2421 5690543 90.72 µM 1.24087985730379 0.124399928094893 no 404 0.107325067410665 152 3397993
SGTC_327 1273-0057 3.96 µM 1.23714291590089 0.125104687912809 no 405 0.108017014795482 122 3108138
SGTC_1074 carmofur 3.8 µM 1.22923814189878 0.126604645717327 no 406 0.109491266089064 151 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3072 9116419 49.47 µM 1.22768771142142 0.126900308423459 no 407 0.109782110610963 132 17170162
SGTC_954 1189-0853 2.85 µM 1.22424760681887 0.12755804205705 no 408 0.110429417508816 133 2828194
SGTC_1852 st056254 31.4 µM 1.22409163580093 0.127587919130799 no 409 0.110458830487948 128 442583
SGTC_836 0330-0104 1.35 µM 1.22208156269204 0.127973394685053 no 410 0.110838392318011 130 46494820
SGTC_2264 7948757 110.76 µM 1.22172952767103 0.12804098828807 no 411 0.110904963085248 120 2971411
SGTC_630 4356-0227 183 µM 1.2214154241554 0.12810131966518 no 412 0.110964385078289 174 779312
SGTC_460 trequinsin 123 µM 1.21978788206311 0.128414245737912 no 413 0.111272648153896 145 5537 A vasodilator.
SGTC_2087 5276107 200 µM 1.21943236954286 0.128482670372323 no 414 0.111340065173822 130 144405
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.21876221627053 0.128611721956581 no 415 0.111467228058602 130 97141
SGTC_3138 9097216 49.47 µM 1.2182916815811 0.128702386674583 no 416 0.111556575016484 151 25237486
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.21762844498763 0.128830257344956 no 417 0.111682599965724 173 2346 DNA damaging agent; causes G2/M arrest.
SGTC_921 1561-0023 372 µM 1.21576465926291 0.129190063145333 no 418 0.112037292502437 154 24050882
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.21574525754735 0.129193812326902 no 419 0.11204098902637 126 16486 A toxic proline analog.
SGTC_601 0986-0029 62.9 µM 1.21378947580618 0.129572134061483 no 420 0.112414063076267 141 24747981
SGTC_1460 k062-0059 9.15 µM 1.21275261989875 0.12977301196388 no 421 0.112612207547509 133 1373085
SGTC_105 0111-0055 734.78 µM 1.21162488449121 0.129991741359165 no 422 0.112828002258345 121 5179370
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.20532921840845 0.131217502507172 no 423 0.114038117151978 134 4620898
SGTC_2721 ifenprodil 61.44 µM 1.20282368433796 0.131707541630033 no 424 0.114522278747801 138 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2317 5986382 200 µM 1.20073337600508 0.132117334878138 no 425 0.114927321487501 150 877883
SGTC_89 0302-0250 142.109 µM 1.19960744562302 0.132338431162855 no 426 0.11514591676272 156 4203518 YLR208W SEC13
SGTC_2728 chlorpromazine 9.18 µM 1.19891100525203 0.132475317095584 no 427 0.115281276006343 140 2726 A thorazine and dopamine antagonist.
SGTC_1228 0124-0032 52.5 µM 1.19833962747383 0.132587694705107 no 428 0.115392412681009 120 X1228
SGTC_2019 4016004 108 µM 1.19775391727695 0.132702959338108 no 429 0.115506416113931 159 45595336
SGTC_2727 riluzole 51.77 µM 1.19719663087529 0.132812694378526 no 430 0.115614961376255 143 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2348 9022543 33.42 µM 1.19622628756572 0.133003913380369 no 431 0.115804132545334 174 3162678 YDL140C RPO21
SGTC_2232 chlorophetanol 41.5365 µM 1.1957895863909 0.133090032941386 no 432 0.11588934035806 144 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2903 5923464 63.88 µM 1.19458498945107 0.13332778413771 no 433 0.116124608399564 143 2876576
SGTC_2775 cyproheptadine 69.59 µM 1.19260759737879 0.133718695034766 no 434 0.116511544514008 136 2913 A selective serotonin reuptake inhibitor.
SGTC_673 1082-0474 110 µM 1.19224350228385 0.133790758853677 no 435 0.116582890223333 179 3098046
SGTC_1431 4049-0260 9.09 µM 1.19173166105392 0.133892110583497 no 436 0.11668323968926 163 3854841
SGTC_2092 5303694 80.6725 µM 1.19160289775185 0.133917615824936 no 437 0.116708494126333 149 1963699
SGTC_3113 9123498 49.47 µM 1.19099276631538 0.1340385151362 no 438 0.116828212322356 156 8897275
SGTC_3338 9144300 39.5675 µM 1.18978427003928 0.134278203495182 no 439 0.117065596824586 116 4901274
SGTC_1386 3228-0095 33.8 µM 1.18635104554097 0.13496074093122 no 440 0.117741847936692 129 870181
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.1850043507524 0.135229117392502 no 441 0.118007863352214 173 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_510 ag-490 170 µM 1.18399484734619 0.135430536347387 no 442 0.118207551251822 126 5328779
SGTC_1990 st072050 59.8 µM 1.18250743855884 0.135727682797451 no 443 0.118502207874112 143 17233948
SGTC_1940 st075990 51.1 µM 1.18191427643525 0.135846305962363 no 444 0.11861985832811 142 1084979
SGTC_3028 9087778 49.47 µM 1.18088278983964 0.136052756209606 no 445 0.118824644541746 147 17217395
SGTC_2227 7312221 64.1025 µM 1.18042136674701 0.136145178729482 no 446 0.118916333980309 167 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2234 tolnaftate 200 µM 1.17951440880085 0.136326966585736 no 447 0.119096701303395 134 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2342 7990637 118.86 µM 1.17904443491024 0.136421232000187 no 448 0.119190241254937 162 2033102 YER133W GLC7
SGTC_1068 loratadine 26.9 µM 1.17644709024572 0.136943000678529 no 449 0.119708131819301 150 3957 A H1 histamine antagonist.
SGTC_2823 7987624 58.44 µM 1.17545644794048 0.137142365084356 no 450 0.119906075733067 158 2239440
SGTC_1755 st041960 45.185 µM 1.17519325298602 0.137195365762516 no 451 0.119958704467107 174 2257073
SGTC_2624 nerol 100 µM 1.17505988284967 0.137222228410082 no 452 0.119985379512124 155 637566 A natural product oil.
SGTC_3169 9102970 49.47 µM 1.17478301546805 0.137278004918847 no 453 0.120040768449473 142 17027839
SGTC_2135 5326629 150.42 µM 1.16659484305331 0.138934561291342 no 454 0.121687013457731 134 5020077
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.16298722778587 0.139668722944919 no 455 0.122417342243679 163 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2561 acetosyringone 100 µM 1.16291315106514 0.139683825389219 no 456 0.122432370560628 164 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2047 4141938 200 µM 1.16086278922763 0.140102285088814 no 457 0.122848851735906 152 3807862
SGTC_880 0833-0487 87.2 µM 1.16058409061109 0.140159230555834 no 458 0.122905539193876 151 76075
SGTC_276 colchicine 750 µM 1.15779787124717 0.140729392864909 no 459 0.123473266155641 154 2833 A microtubule depolymerizer.
SGTC_300 r073-0011 5.04 µM 1.15776915727493 0.140735276975082 no 460 0.123479126532875 149 2735780
SGTC_1842 st055362 61.2 µM 1.15734474162081 0.140822268336806 no 461 0.123565770354857 140 676032
SGTC_2622 2-methoxyxanthone 59.94 µM 1.15602591942856 0.141092816635569 no 462 0.123835277621396 151 71034 A hepatoprotective.
SGTC_497 capsazepine 133 µM 1.15369207085566 0.141572454682817 no 463 0.124313217919414 137 2733484 A calcium channel blocker.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.15278076488436 0.141760040167108 no 464 0.124500190703096 137 2374 Ca(2+)-ATPase inhibitor.
SGTC_1787 fluconazole 80 µM 1.1518406940837 0.141953722994635 no 465 0.124693271099239 147 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_902 1120-0002 2.07 µM 1.14876241808111 0.142589193732968 no 466 0.125326980023664 160 3280475
SGTC_3053 9095903 49.47 µM 1.14570717465284 0.14322180909449 no 467 0.125958167104129 177 17174018
SGTC_2214 7179297 48.276 µM 1.14340655882314 0.143699421433565 no 468 0.126434915291629 138 769744
SGTC_3196 9111891 49.47 µM 1.13991978856474 0.14442532848341 no 469 0.127159859993549 155 18891510
SGTC_2043 5101342 149 µM 1.13510653873335 0.145431447536933 no 470 0.128165341108588 162 678451
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.13504058098899 0.145445267422654 no 471 0.128179157833018 158 91467 include heat shock
SGTC_1539 benzyladenosine 56 µM 1.13394460773714 0.145675031979499 no 472 0.128408891994269 157 92208 A nucleotide analog.
SGTC_1337 1486-1011 40.3 µM 1.12905814375483 0.146702419590226 no 473 0.129436653348009 140 X1337
SGTC_579 4491-1009 110 µM 1.12824318509861 0.146874237961951 no 474 0.129608615206043 169 1271041
SGTC_1762 st045503 25.4615 µM 1.1265833687815 0.147224595601231 no 475 0.12995933702557 138 4645554
SGTC_1339 1486-1321 22.7 µM 1.12645710097567 0.147251271395407 no 476 0.129986044477947 158 3469382
SGTC_402 epigallocatechin gallate 10 µM 1.12317933967339 0.147944876786204 no 477 0.130680667656704 180 65064 An antioxidant.
SGTC_3241 9133421 49.47 µM 1.12250817451463 0.148087171023056 no 478 0.13082321692255 156 17018221
SGTC_469 w7 172 µM 1.12067493190989 0.148476304796263 no 479 0.131213128227402 134 45115570 A P450 inhibitor.
SGTC_3264 9137442 49.47 µM 1.12060132364413 0.148491943542174 no 480 0.131228800669446 149 17015726
SGTC_457 grayanotoxin iii 135 µM 1.11861679268628 0.148913990383215 no 481 0.131651828156757 171 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_509 pifithrin 175 µM 1.11774926569557 0.149098737402756 no 482 0.131837047628522 175 4817 A p53 inhibitor.
SGTC_3037 9091026 49.47 µM 1.11499916559614 0.149685405376293 no 483 0.132425389645025 162 25236398 YIL048W NEO1
SGTC_3268 9137683 49.47 µM 1.11495723365929 0.149694362454591 no 484 0.132434374326122 187 1953228
SGTC_1474 0330-0125 5.35 µM 1.11431426682015 0.149831751338844 no 485 0.132572194285878 143 X1474
SGTC_879 0831-1030 162 µM 1.11367132013575 0.14996921999118 no 486 0.132710108699667 187 1549252
SGTC_651 3253-0966 34.4 µM 1.1095779356668 0.150846399696228 no 487 0.133590471750404 161 781462
SGTC_2582 agaric acid 100 µM 1.10951400296415 0.150860126999387 no 488 0.133604253515475 187 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.10903770675528 0.150962421060981 no 489 0.133706957915155 152 229346 A bile salt which induces apoptosis.
SGTC_1821 st053465 65.6 µM 1.10878618910774 0.151016458087711 no 490 0.133761214901761 141 675086
SGTC_1937 st074714 47.2 µM 1.10770208423288 0.151249518678879 no 491 0.133995249478921 140 17250970
SGTC_2529 gangaleoidin 93.61 µM 1.10441680708218 0.151957247105242 no 492 0.134706186689509 159 4565183
SGTC_1960 st011366 51.8 µM 1.10403480509847 0.152039682137457 no 493 0.134789019972928 176 3972846
SGTC_1368 1852-0141 284 µM 1.10182916473791 0.152516234331339 no 494 0.13526797427384 164 2838987
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.10029917477732 0.152847386642178 no 495 0.135600895794065 173 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2833 9001315 45.46 µM 1.09996345471646 0.152920113916551 no 496 0.135674022575988 156 2989378
SGTC_1242 0402-0103 60.1 µM 1.0946880211721 0.154065947568385 no 497 0.136826669165466 157 432868
SGTC_788 1182-0090 188 µM 1.09454744492837 0.154096558476851 no 498 0.136857475411962 163 5715185
SGTC_1040 k898-0338 155 µM 1.09433958644573 0.154141827671641 no 499 0.13690303475136 173 20969351
SGTC_2945 9067681 61.76 µM 1.09020250038544 0.155044667440895 no 500 0.137811976089104 202 16456930
SGTC_2280 7785178 200 µM 1.08651367737379 0.155852621346225 no 501 0.138625896532404 154 2954328
SGTC_2881 9058953 51.95 µM 1.08053278568295 0.157168489864723 no 502 0.139952497620818 159 17122249
SGTC_703 3875-0075 71.8 µM 1.07606759883654 0.158155634433824 no 503 0.140948512592224 185 2850814
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.07497860693794 0.158397000044935 no 504 0.141192153191521 160 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.07283456083522 0.158872915126767 no 505 0.141672675591693 154 6708514
SGTC_2654 protoveratrine a 100 µM 1.07185315464606 0.159091070736948 no 506 0.141892996956207 183 5702278 A heart drug and vasodilator.
SGTC_2686 alizarin 95.37 µM 1.07138547670552 0.159195099317784 no 507 0.141998070170598 142 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_208 k072-0098 12.366 µM 1.06830097955086 0.159882319346571 no 508 0.142692383390296 175 5948901
SGTC_2756 carbadox 75.1 µM 1.06782405919403 0.159988749238528 no 509 0.142799941602041 188 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_479 n-linoleoylglycine 10 µM 1.0673699514357 0.160090131305149 no 510 0.142902405887994 178 6433346 An anti-infammatory.
SGTC_2673 kobusone 100 µM 1.06734775940369 0.160095086875239 no 511 0.142907414542462 194 6710676 An epoxy ketone and protein crosslinker.
SGTC_3019 9081971 49.47 µM 1.06497600138723 0.160625288134304 no 512 0.143443394977965 157 16451803
SGTC_1928 4'-methoxychalcone 40.3 µM 1.06468455736648 0.160690518833115 no 513 0.143509350305286 187 641818
SGTC_969 1313-0238 134 µM 1.06459834052045 0.160709819113675 no 514 0.143528865557948 200 5212874
SGTC_1621 st003705 32.4 µM 1.06306598549422 0.161053100692376 no 515 0.143876014219607 168 24207032
SGTC_3192 9110362 49.47 µM 1.06073245227294 0.161576782513285 no 516 0.14440575369095 161 16649480
SGTC_2502 avocadyne acetate 18.59 µM 1.05917321996939 0.161927316929797 no 517 0.144760449426109 150 3952079
SGTC_43 0570-0105 72.5 µM 1.05659310469587 0.162508445599669 no 518 0.145348664388766 155 1114046 YDL195W SEC31
SGTC_2436 5633522 8.09 µM 1.05485731169604 0.16290016718632 no 519 0.145745294157038 177 5724242
SGTC_1268 0828-0275 2.46 µM 1.05458591985174 0.162961468447391 no 520 0.145807373067193 179 745337
SGTC_157 1348-1695 65.819 µM 1.05281003235499 0.163362971247863 no 521 0.146214033021852 186 5380510
SGTC_1932 st074806 40.9 µM 1.04398038190199 0.165368760246447 no 522 0.148247233132853 206 17251235
SGTC_2236 dapsone 200 µM 1.0434471126378 0.165490408555986 no 523 0.148370631608373 156 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3109 9122853 49.47 µM 1.04062810256098 0.166134436953785 no 524 0.149024091641565 211 1234709
SGTC_1147 3809-1045 12.3 µM 1.04043729289167 0.166178087580571 no 525 0.149068391600713 167 325925
SGTC_3273 9137859 49.47 µM 1.03956466299385 0.166377809405967 no 526 0.149271100706583 212 2377234
SGTC_1453 4237-0541 195 µM 1.03918556893843 0.166464622246939 no 527 0.14935922035156 177 739892
SGTC_1281 0884-0031 11.8 µM 1.03820372531402 0.166689601146102 no 528 0.149587609334021 179 1548255
SGTC_354 2783-3500 4.88 µM 1.03687455464573 0.166994478750701 no 529 0.149897161989354 181 6740761
SGTC_1113 artemisinin 1.17947 µM 1.03530291531085 0.167355436137604 no 530 0.150263734393299 212 2240 An anti-malaria and mitochondrial poison.
SGTC_1282 0886-0010 32.4 µM 1.03524811184803 0.167368031878701 no 531 0.150276527636471 191 2836211 YNL267W PIK1
SGTC_2433 5607874 27.82 µM 1.03472586155491 0.167488093801691 no 532 0.150398477425902 172 2252428
SGTC_3182 9108849 49.47 µM 1.03390572555529 0.167676749659084 no 533 0.150590119046424 176 17133045
SGTC_2387 9077560 195.08 µM 1.03384747162741 0.167690155011801 no 534 0.150603737456752 170 5303272
SGTC_2388 9080168 200 µM 1.0337554813864 0.167711325146513 no 535 0.150625244300877 191 15943073
SGTC_2098 5376439 882.5 nM 1.03345802049793 0.167779792961011 no 536 0.15069480312315 170 2844116
SGTC_3167 9103034 49.47 µM 1.03326942965163 0.167823211024622 no 537 0.150738914644647 167 5127859
SGTC_1671 st016596 74.5 µM 1.03309770313426 0.167862752813663 no 538 0.150779089066552 190 2829167
SGTC_1093 fluphenazine 7.97 µM 1.03257054875469 0.167984172969749 no 539 0.150902458298898 190 6602611 An atypical antipsychotic.
SGTC_3286 9117135 37.221 µM 1.03249946500345 0.168000550106971 no 540 0.150919099073309 194 3438150
SGTC_447 ml7 120 µM 1.0317900565389 0.168164048536384 no 541 0.151085239194993 176 4216 Selective myosin light chain kinase inhibitor.
SGTC_663 1486-0733 13.9 µM 1.03062812768127 0.168432061094488 no 542 0.151357620267046 181 722445 YPR165W RHO1
SGTC_1249 0481-0015 10.2 µM 1.03037637171835 0.168490167753064 no 543 0.151416680288575 189 4227577
SGTC_2964 9083345 53.42 µM 1.03003540014154 0.168568886411993 no 544 0.151496694039362 190 17741579
SGTC_2865 9030313 51.95 µM 1.02886419912242 0.168839456660549 no 545 0.15177174682818 153 42562754
SGTC_3008 9078912 71.4286 µM 1.02817487763386 0.168998833723254 no 546 0.151933786794648 186 16648731
SGTC_982 1491-0518 27.5 µM 1.02660855002471 0.169361341274111 no 547 0.152302413193372 162 3091256
SGTC_200 k038-0079 37.545 µM 1.02468612637697 0.169806944585842 no 548 0.152755655660186 197 3436683
SGTC_2731 amoxapine 43.43 µM 1.02174078152297 0.170491110218308 no 549 0.153451801922293 199 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3304 9125678 46.087 µM 1.02055233411944 0.170767670357473 no 550 0.153733291199256 182 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_583 1488-1091 88.9 µM 1.01809936579043 0.171339400806502 no 551 0.154315368358773 213 4303273
SGTC_3352 9151559 45.5865 µM 1.01623362073137 0.171775081364099 no 552 0.154759074891728 170 17159339
SGTC_2597 laccaic acid a 100 µM 1.01561448274217 0.171919815960883 no 553 0.154906502726235 164 5491415 A textile dye.
SGTC_1911 st060208 74.3 µM 1.00767889757538 0.173781792194992 no 554 0.156804319410136 192 688783
SGTC_2118 5526350 200 µM 1.00759217425211 0.173802211232794 no 555 0.156825143690665 187 743594
SGTC_2142 5622915 118.518 µM 1.00632599883693 0.174100506461337 no 556 0.157129389001166 165 5322196
SGTC_1514 1189-1591 158 µM 1.00622253018016 0.17412489676892 no 557 0.157154268304161 199 767698 YMR146C TIF34
SGTC_1713 st033146 12.748 µM 1.00374669344875 0.174709164837091 no 558 0.157750362156788 173 674619
SGTC_1328 1441-0025 69.2 µM 1.00271794385163 0.17495230312708 no 559 0.157998484832715 169 4562601
SGTC_3210 9128157 49.47 µM 1.00003536258315 0.175587323129552 no 560 0.158646697372885 166 17590849
SGTC_1863 st057641 20.1 µM 0.996349686601833 0.176462174245078 no 561 0.159540135009842 207 3921635
SGTC_3274 9138298 49.47 µM 0.996124331391603 0.176515755022877 no 562 0.15959486956587 202 17015756
SGTC_773 4358-1457 44.6 µM 0.9957150594979 0.176613090405901 no 563 0.159694305460237 197 1186886
SGTC_2356 9061756 188.97 µM 0.995144430781301 0.176748857230881 no 564 0.159833011939777 177 20104043
SGTC_795 0685-0265 78 µM 0.994140260019711 0.176987934705386 no 565 0.160077293656439 196 302754
SGTC_3143 9086658 49.47 µM 0.993115663502297 0.177232085746741 no 566 0.160326795767313 201 25236626
SGTC_1800 st050079 29.0735 µM 0.988051359088147 0.178441980321652 no 567 0.161563747900474 201 3645560
SGTC_931 2812-0076 566 µM 0.986394987739341 0.17883882453686 no 568 0.161969661862553 177 3450959
SGTC_704 1310-0270 142 µM 0.984428644320122 0.179310654459739 no 569 0.16245239993001 194 5718033
SGTC_1473 k844-0725 134 µM 0.983765519170463 0.179469949645038 no 570 0.162615408319399 209 54682906
SGTC_1773 st048542 73.5835 µM 0.98336800193776 0.179565483425696 no 571 0.162713176382076 217 3237138
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.981875420369702 0.179924475013631 no 572 0.163080613150714 195 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_371 0195-0006 7.36 µM 0.980547083288438 0.180244341755799 no 573 0.163408070176595 179 3928593
SGTC_2279 7948423 32.93 µM 0.979818985557225 0.180419820754614 no 574 0.163587739372727 176 1247112
SGTC_951 1171-0579 82.7 µM 0.977461976882204 0.180988618689359 no 575 0.164170246513811 194 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1780 st038448 24.544 µM 0.975592775780377 0.181440495923278 no 576 0.164633152973131 185 728868 YDL195W SEC31
SGTC_1038 k292-0204 154 µM 0.97509191190341 0.181561699073711 no 577 0.164757335128668 181 4454212
SGTC_696 1560-0013 611 µM 0.973092418057959 0.182046057751074 no 578 0.165253685978687 220 1650269
SGTC_1443 4112-3303 14 µM 0.972388917978723 0.18221666601106 no 579 0.165428551503915 205 704433
SGTC_1041 0206-0046 107 µM 0.970612905547861 0.182647817380943 no 580 0.165870538460441 193 50494
SGTC_2930 9013230 14.89 µM 0.966643967412826 0.183613631638796 no 581 0.16686102350575 190 2995857
SGTC_753 1322-0200 289 µM 0.964175102246142 0.184216015789635 no 582 0.167479072381878 180 5403907
SGTC_2408 sulbentine 18.36 µM 0.963619082748319 0.184351849779575 no 583 0.167618467994577 186 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2674 ligustilide 100 µM 0.962654027481618 0.184587757948187 no 584 0.167860587353433 194 5319022 A signalling regulator.
SGTC_1687 st020778 55.3625 µM 0.961950631592756 0.184759821595956 no 585 0.168037201687885 174 4259299
SGTC_3088 9117578 49.47 µM 0.961930719014346 0.184764694031802 no 586 0.168042203239305 203 678341
SGTC_1481 3346-2004 36 µM 0.961755211141097 0.184807642746108 no 587 0.168086290656867 216 2770522
SGTC_1769 st044406 64.4 µM 0.959305726267254 0.185407706250041 no 588 0.16870237574412 235 670903
SGTC_448 monastrol 171 µM 0.95905114165279 0.185470142526709 no 589 0.168766491048068 216 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_14 0354-0009 295 µM 0.956729950999735 0.186040010833682 no 590 0.169351788301937 208 1713507
SGTC_1144 3486-0183 12.5 µM 0.955793098482088 0.186270321723909 no 591 0.16958838790721 207 6744069
SGTC_1202 1988-0068 29.6 µM 0.953630864879248 0.186802547876652 no 592 0.170135263317495 173 2850480
SGTC_275 trichlorophene 5.69 µM 0.953552105479558 0.186821951973827 no 593 0.170155204573229 188 62616
SGTC_2575 plumbagin 510 nM 0.95336808732537 0.186867293724663 no 594 0.170201802348814 192 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1906 st060206 94.7 µM 0.950038491457855 0.187688876299331 no 595 0.171046347383813 208 5133468
SGTC_2095 5432005 200 µM 0.949944897774355 0.187712002872829 no 596 0.171070125894347 197 783734
SGTC_2649 anisomycin 9.56 µM 0.949177790661325 0.187901617882435 no 597 0.171265097616747 192 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1757 st041620 31.8375 µM 0.947601116000742 0.188291714537189 no 598 0.171666278915502 181 5289815
SGTC_515 4092-1064 102 µM 0.947236791043542 0.188381925865933 no 599 0.171759065896448 214 717353
SGTC_144 4161-2749 112.381 µM 0.946746139506739 0.188503459325589 no 600 0.171884076582609 208 797501 YMR168C CEP3
SGTC_26 0302-0163 425.158 µM 0.944201935239283 0.189134428988549 no 601 0.172533233243411 229 3100915
SGTC_96 0929-0093 37.281 µM 0.943586108287355 0.189287351057106 no 602 0.172690596914773 225 6991579
SGTC_756 0508-1999 28.3 µM 0.940739420008089 0.189995229001079 no 603 0.17341920623913 197 6753853
SGTC_2364 9055074 200 µM 0.940396301723989 0.19008066100631 no 604 0.173507159254453 183 6470630
SGTC_3135 9127742 49.47 µM 0.940308341684493 0.190102565717219 no 605 0.173529711008258 207 3643468
SGTC_3163 9099914 49.47 µM 0.938602610038849 0.190527651166353 no 606 0.173967406118368 219 16268368
SGTC_508 roscovitine 141 µM 0.937065258187611 0.190911274278478 no 607 0.174362495431708 218 160355 A CDKinase inhibitor.
SGTC_3184 9108758 49.47 µM 0.936397497131065 0.191078051545136 no 608 0.174534283067327 199 902885
SGTC_1141 3253-0389 52.6 µM 0.935260624771114 0.191362197591866 no 609 0.174827001062438 211 5402031
SGTC_229 benomyl 22.8748 µM 0.934924300332372 0.191446306999231 no 610 0.174913656415741 182 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2762 leflunomide 42.06 µM 0.934600394731177 0.191527332061625 no 611 0.174997137766446 222 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_975 1335-0046 28.5 µM 0.927279590157563 0.193364232103777 no 612 0.176890694197837 207 16486740
SGTC_850 0388-0143 75.9 µM 0.92615128284131 0.193648294415029 no 613 0.17718368304606 194 67273
SGTC_726 3448-4391 34.2 µM 0.924030436633737 0.19418292626088 no 614 0.177735234610538 211 1356692
SGTC_350 k064-0020 19.8 µM 0.920773298515351 0.195005747841843 no 615 0.178584399182125 204 2790705
SGTC_2943 9068529 45.32 µM 0.920712824444894 0.19502104488005 no 616 0.178600189425791 240 3270634
SGTC_2224 6650123 117.647 µM 0.918387581943119 0.19560977282359 no 617 0.17920799482177 194 2908370
SGTC_246 cycloheximide 667 µM 0.918367586739768 0.195614840082313 no 618 0.179213227091598 205 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_416 estradiol valerate 100 µM 0.916489065057073 0.196091257430461 no 619 0.179705220089478 225 13791 A steroid.
SGTC_2260 7964312 200 µM 0.916117946814647 0.196185460988204 no 620 0.179802517865591 210 231951
SGTC_1952 st077036 64.1 µM 0.915266769302672 0.196401624997194 no 621 0.180025799947558 190 2937007
SGTC_776 4476-4378 112 µM 0.914088436143976 0.196701111195086 no 622 0.180335189150367 209 2892008
SGTC_781 4335-2806 94.4 µM 0.910025754998149 0.197735804865948 no 623 0.181404463686345 211 845254
SGTC_743 1275-0778 158 µM 0.909938512777087 0.197758059942513 no 624 0.181427468790819 233 2849257 YMR203W TOM40
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.909033592230575 0.197988990139538 no 625 0.181666197110349 181 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_284 0988-0104 32.6 µM 0.908019030049224 0.198248093782752 no 626 0.181934083743473 221 4666532
SGTC_1516 st013856 110 µM 0.906663642068747 0.198594558295224 no 627 0.182292347809103 200 5281404 A mutagen and neurotoxin.
SGTC_1614 st002383 48.6 µM 0.905671447910312 0.198848414506434 no 628 0.182554889649686 188 1947235
SGTC_24 0417-1663 219 µM 0.905209692993557 0.198966622722658 no 629 0.182677153867043 202 4329390
SGTC_2366 9070441 60.58 µM 0.904060702180815 0.19926094550921 no 630 0.182981607352509 190 6837235
SGTC_2900 5328528 85.29 µM 0.90294001623 0.199548270234105 no 631 0.183278865587925 219 795359
SGTC_990 3985-0011 41.3 µM 0.902812855295593 0.199580887868852 no 632 0.183312613617136 213 5399565 YGL099W LSG1
SGTC_1335 1486-0900 202 µM 0.902382027486727 0.199691421947493 no 633 0.183426982482917 212 X1335
SGTC_1310 1188-0297 994 nM 0.902067184009084 0.199772222133143 no 634 0.183510589919073 195 1588352
SGTC_3159 9100096 49.47 µM 0.900531220387816 0.200166687689944 no 635 0.183918809227957 190 25236875
SGTC_513 4245-1575 41.7 µM 0.898702495292316 0.200636950107766 no 636 0.184405573774425 224 719745
SGTC_147 4466-0538 29.23 µM 0.898242388143788 0.20075537246574 no 637 0.184528169786468 225 6742687 YHR072W ERG7
SGTC_1515 3460-0031 42.1 µM 0.896769781033929 0.201134673937079 no 638 0.184920888068934 209 2876596
SGTC_1239 0337-0584 35.4 µM 0.895722217286443 0.201404757814376 no 639 0.185200570705366 217 914301 YML130C ERO1
SGTC_1934 st074720 32.6 µM 0.895266169238917 0.201522404432219 no 640 0.185322410218343 195 17250992
SGTC_1419 3993-2473 62.6 µM 0.893069665688867 0.202089612492504 no 641 0.185909933206382 221 704026
SGTC_1870 st057514 26.5 µM 0.892706917760366 0.20218337753665 no 642 0.186007072396162 215 5393161
SGTC_614 0462-0418 107 µM 0.891978453025155 0.202371753636592 no 643 0.186202240829271 200 5188303
SGTC_3057 9095946 49.47 µM 0.890336154339984 0.202796825941308 no 644 0.186642706694079 238 24540043
SGTC_2070 5230947 200 µM 0.88675736358616 0.203724961695199 no 645 0.187604773532741 235 2835538
SGTC_3074 9116018 49.47 µM 0.886506700548541 0.203790064260994 no 646 0.18767227253684 250 17027303
SGTC_560 2332-1943 155 µM 0.884820764981321 0.20422825999367 no 647 0.188126654075652 211 21177716
SGTC_2254 7938975 95.19 µM 0.884780164181983 0.204238819563208 no 648 0.188137604884164 205 2969277
SGTC_1648 st011736 69.8 µM 0.884064499536864 0.204425004996402 no 649 0.188330697841292 215 2855514
SGTC_1269 0831-0796 3.05 µM 0.88348976832777 0.204574598675474 no 650 0.18848585412976 211 927758
SGTC_1564 D-Arginine 115 µM 0.880556188206398 0.205339178568834 no 651 0.189279040299631 232 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_693 4161-2696 114 µM 0.880388207475868 0.205383010756623 no 652 0.189324521319561 246 805759
SGTC_3098 9119039 49.47 µM 0.879896489476166 0.205511349528434 no 653 0.189457693325256 205 17161528
SGTC_2244 6635614 200 µM 0.878888492439652 0.205774586328818 no 654 0.189730869356174 189 836499
SGTC_698 k064-0052 127 µM 0.877484588617792 0.20614154674433 no 655 0.190111743019308 240 5088751
SGTC_1629 st005085 44.9 µM 0.877401934838179 0.206163163349219 no 656 0.190134181304977 234 24207091
SGTC_2017 5132927 60.65 µM 0.874573208430781 0.206903775422789 no 657 0.190903085311713 187 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_108 0509-0257 621.132 µM 0.872597274262509 0.207422043819383 no 658 0.191441313387714 206 536624
SGTC_3161 9100388 49.47 µM 0.871909884939605 0.207602519148615 no 659 0.191628770322941 234 25236368
SGTC_2373 9071805 200 µM 0.871884429910183 0.207609204194508 no 660 0.191635714284791 226 10149009
SGTC_1203 3992-3522 103 µM 0.871605981708229 0.207682339070637 no 661 0.191711683155981 232 5322312
SGTC_2004 4023728 41.89 µM 0.871283495011733 0.207767059748414 no 662 0.191799690070366 248 360084 YDR527W RBA50
SGTC_438 sphingosine 6.67 µM 0.8694248481095 0.208255743748382 no 663 0.192307398471863 191 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_582 0987-0078 156 µM 0.869377712471928 0.20826814567793 no 664 0.192320284730543 230 1625765
SGTC_281 1672-3440 14.9 µM 0.869337741951466 0.208278662723984 no 665 0.19233121255492 212 6833000
SGTC_1355 1499-0035 1.68 µM 0.868789780091299 0.208422874073878 no 666 0.192481062022339 218 1548538
SGTC_10 0279-0212 42.575 µM 0.86805367346601 0.208616693594855 no 667 0.192682475176755 216 39851 YBR002C RER2
SGTC_838 0109-0203 71.4 µM 0.867684123417124 0.208714037498672 no 668 0.192783639831503 206 759422
SGTC_2726 cimetidine 79.27 µM 0.867641772233316 0.208725195016656 no 669 0.192795235577946 230 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.867572076903599 0.208743557178773 no 670 0.192814319074161 195 688664
SGTC_2927 9011802 47.9 µM 0.866955148118339 0.208906136782424 no 671 0.192983292586741 218 43912568
SGTC_181 1447-1644 8.07 µM 0.866362056963428 0.209062504746924 no 672 0.19314582232698 237 534600
SGTC_1181 1222-0449 220 µM 0.865928709566598 0.209176799975681 no 673 0.193264628962611 220 658318
SGTC_1844 rapamycin 4 nM 0.864948733312123 0.209435404000851 no 674 0.193533463935514 229 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2222 6885208 172.143 µM 0.862295638605966 0.210136467327037 no 675 0.194262426080595 204 609514
SGTC_3229 9132204 49.47 µM 0.862176891291335 0.210167877743256 no 676 0.194295092042237 204 17682924
SGTC_1608 st001473 40.5 µM 0.860335685669375 0.210655256568134 no 677 0.194802013511415 249 7292267
SGTC_2725 haloperidol 53.21 µM 0.860333664060213 0.210655792065105 no 678 0.19480257054341 229 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1323 1348-1351 11.2 µM 0.859551217600368 0.210863111535316 no 679 0.195018237738826 222 6989654
SGTC_1664 st014217 9.02 µM 0.858527833404393 0.211134451133699 no 680 0.195300534046507 216 3982782
SGTC_2416 tofa 880 nM 0.858102990103492 0.211247153962583 no 681 0.195417798209009 213 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3348 9149464 3.537 µM 0.855788480625969 0.211861767986754 no 682 0.196057394042139 196 1951442
SGTC_2429 5902844 64.44 µM 0.852216143680332 0.212812446577252 no 683 0.197047069051158 223 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2140 5586273 200 µM 0.851693202868897 0.212951821441537 no 684 0.19719219708828 203 854421
SGTC_198 3454-2873 16.191 µM 0.848592574578606 0.213779298413403 no 685 0.198054020106534 233 710957
SGTC_3175 9106517 49.47 µM 0.848190205177666 0.21388681743453 no 686 0.198166025616273 219 41468073
SGTC_343 4130-2827 29.8 µM 0.846925334274396 0.214225014530093 no 687 0.1985183702271 206 1118244
SGTC_2138 5575593 77.673 µM 0.844748853799 0.214807682510505 no 688 0.199125538277096 223 762213
SGTC_1675 st018485 24.5 µM 0.84470029905705 0.21482069164433 no 689 0.199139096232954 241 3323024
SGTC_2434 5670830 169.91 µM 0.842871355230929 0.215311048593662 no 690 0.199650197681853 226 1549830
SGTC_1981 st071826 47 µM 0.842372902443743 0.215444800990747 no 691 0.199789627909088 218 11838600
SGTC_1164 k060-0068 93.7 µM 0.842369376043957 0.215445747419386 no 692 0.199790614543569 235 5963676
SGTC_768 0384-0033 77.3 µM 0.841444228090925 0.215694125461011 no 693 0.200049558485713 216 3965305 YMR134W ERG29
SGTC_648 0375-0473 33.3 µM 0.840278027882413 0.216007456130432 no 694 0.200376258966254 235 1713139
SGTC_3220 9131269 49.47 µM 0.840035466444347 0.216072659814704 no 695 0.200444250610392 248 17722206
SGTC_1770 st043884 66.3 µM 0.83960836212984 0.216187498741346 no 696 0.200564004572275 258 670149
SGTC_1910 st062352 60.4 µM 0.838877876274839 0.216383992164447 no 697 0.200768921941558 224 2245730
SGTC_405 ebelactone b 50 µM 0.838582601784951 0.21646344738947 no 698 0.200851788588858 202 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2120 5538279 151.968 µM 0.837879133566297 0.216652811216357 no 699 0.201049294530152 195 2058197
SGTC_912 3474-0017 2.18 µM 0.836466935813795 0.21703324425271 no 700 0.20144613507769 219 3360550
SGTC_3035 9091303 49.47 µM 0.832770096748393 0.218030964591881 no 701 0.202487201306553 232 25237002
SGTC_1914 st062367 72.6 µM 0.832057302354145 0.218223640511244 no 702 0.202688300480361 230 978205
SGTC_1865 st057639 52.2 µM 0.831343065282412 0.218416804776427 no 703 0.202889926340573 241 688818
SGTC_2229 7354935 190 µM 0.83091656932239 0.218532196865754 no 704 0.203010381308428 250 318112
SGTC_620 0109-0052 432 µM 0.83032535074438 0.218692214094252 no 705 0.203177429386901 254 493037
SGTC_2060 5238662 140 µM 0.829576619383603 0.218894959953974 no 706 0.203389100220443 242 790130
SGTC_964 1287-0107 19.4 µM 0.828594817058623 0.219160981925143 no 707 0.203666860900508 207 51516812 YPR165W RHO1
SGTC_2872 9044037 25.97 µM 0.827390485840687 0.219487552390153 no 708 0.204007885706116 220 6465195
SGTC_521 r062-0005 13.8 µM 0.826700415375703 0.219674800104915 no 709 0.204203442938897 221 2832033
SGTC_2569 tetrandrine 100 µM 0.826620951403855 0.219696368206843 no 710 0.204225969188059 217 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_129 0088-0017 176.636 µM 0.826595899587006 0.219703168020107 no 711 0.204233071121595 219 182446
SGTC_228 caffeine 993.056 µM 0.826403195799783 0.21975547763803 no 712 0.204287705588404 187 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2810 7959871 45.46 µM 0.825929083310079 0.219884206334789 no 713 0.204422160758056 225 2974535
SGTC_2657 nystatin 74.44 µM 0.823587180954324 0.220520702662565 no 714 0.20508708110608 224 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.819852690335392 0.221537865944332 no 715 0.206150044732118 214 6708739 YPR165W RHO1
SGTC_235 0330-0087 5 mM 0.819504574079314 0.22163281882552 no 716 0.206249296668375 232 46494818 YHR062C RPP1
SGTC_1396 3511-0007 98.6 µM 0.818158255606056 0.222000262150644 no 717 0.206633414012028 231 X1396
SGTC_1002 4049-0206 172 µM 0.817569565832278 0.222161039252611 no 718 0.206801505788508 239 4662749
SGTC_3239 9133757 49.47 µM 0.817282084940372 0.222239577320927 no 719 0.206883621171735 258 17036923
SGTC_1781 st038725 66.3 µM 0.81502998750609 0.222855384862552 no 720 0.207527572607201 244 4270275 YIL048W NEO1
SGTC_2134 5324836 1.464 µM 0.814181090123962 0.223087757157937 no 721 0.207770608387045 246 699272
SGTC_1438 4092-1045 4 µM 0.814159325751129 0.223093716625813 no 722 0.207776841645748 248 1351342
SGTC_1859 st055998 20 µM 0.81412713645787 0.223102530786336 no 723 0.207786060776514 238 676301
SGTC_1458 k015-0034 6.33 µM 0.814068672139865 0.223118540153278 no 724 0.20780280578792 226 3598957
SGTC_3078 9116413 49.47 µM 0.812963605981471 0.223421264983787 no 725 0.208119462316163 256 17177322
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.812359937731465 0.223586734153819 no 726 0.20829256356488 242 23847180
SGTC_724 3910-0327 137 µM 0.812350210524054 0.223589401011478 no 727 0.208295353526754 248 2885483
SGTC_2210 7115885 190.385 µM 0.812291392397017 0.223605527255621 no 728 0.208312224237304 239 2927039
SGTC_2773 thioridazine 9.09 µM 0.812013689445782 0.22368167437632 no 729 0.208391888223173 235 5452 An antipsychotic.
SGTC_1159 4092-0538 61.2 µM 0.811236263693578 0.223894925632707 no 730 0.208615002044513 254 717301
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.808287744705254 0.224704766410568 no 731 0.209462477922056 243 5355888
SGTC_2698 st077697 67.5 µM 0.808130184663894 0.224748088589845 no 732 0.209507821438611 238 3154499
SGTC_1550 gossypolone 36.6 µM 0.807805030600721 0.224837506829321 no 733 0.209601414359427 246 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2450 5739737 12.93 µM 0.807744440702528 0.224854171442994 no 734 0.209618857380631 235 2262825
SGTC_3335 9143315 29.6265 µM 0.807623193223798 0.224887521388272 no 735 0.209653765471351 228 4899691
SGTC_395 anisomycin 6.25 µM 0.805079584004519 0.225587804571253 no 736 0.210386878137371 243 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2784 7567673 72.73 µM 0.804631121020138 0.225711399129034 no 737 0.210516288898541 228 3471247
SGTC_3280 9140961 49.47 µM 0.804345311078262 0.225790187158301 no 738 0.210598788038763 245 4901226
SGTC_3198 9112019 49.47 µM 0.802227002394354 0.226374617100978 no 739 0.211210829687888 274 45595555
SGTC_2893 9048488 25.97 µM 0.800796953781797 0.22676964239068 no 740 0.211624601410994 250 6467338
SGTC_2093 5331342 194.4 µM 0.799864719492183 0.227027364670518 no 741 0.211894590324358 238 33839
SGTC_1037 k284-1091 78.7 µM 0.799753760295454 0.227058051062597 no 742 0.211926739171561 231 3334711
SGTC_980 1473-0395 201 µM 0.798591030069873 0.22737975128351 no 743 0.212263795259377 267 768876
SGTC_1527 coumarin 137 µM 0.79832393946667 0.227453685247886 no 744 0.212341264597961 252 323 A hepatotoxic, DNA x-linker.
SGTC_2376 9072922 81.32 µM 0.797724900914161 0.227619555719745 no 745 0.212515075151143 223 17087968
SGTC_2989 9073649 71.4286 µM 0.797343237152493 0.227725271818962 no 746 0.212625857913176 252 21367202
SGTC_1840 st055363 71 µM 0.796876466871062 0.227854598921502 no 747 0.212761389759284 247 676033
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.796749880999506 0.227889678936502 no 748 0.212798154040469 248 364106
SGTC_1942 st076330 65.2 µM 0.796596408649885 0.227932213921746 no 749 0.212842731923267 252 24208414
SGTC_31 0508-1974 57.237 µM 0.796439385814095 0.227975737549245 no 750 0.212888346728126 209 6810525
SGTC_2521 angolensin 13.4 µM 0.79558132651967 0.22821365718822 no 751 0.213137711910219 245 821428 A flavenoid.
SGTC_723 4182-0001 115 µM 0.795499088291786 0.228236467240493 no 752 0.21316162054327 220 744821 YLR208W SEC13
SGTC_1305 1181-0477 144 µM 0.794659150222749 0.228469510513041 no 753 0.213405900324999 266 6252086
SGTC_914 3820-6779 408 µM 0.794563046040254 0.228496183419855 no 754 0.213433860772027 230 2893481
SGTC_1195 1502-0147 41.1 µM 0.794095249781831 0.228626041312144 no 755 0.213569991399611 219 817940
SGTC_2993 9054257 71.4286 µM 0.790412406894265 0.229649826345386 no 756 0.214643479410308 250 6470217 YGL055W OLE1
SGTC_421 streptovitacin 30 mM 0.790005542900036 0.229763086838975 no 757 0.214762265619421 239 91467 include heat shock
SGTC_1784 st039334 36.3 µM 0.788637761343347 0.230144071359937 no 758 0.215161876992211 273 3496984
SGTC_3134 9127454 49.47 µM 0.788440754703591 0.230198975073568 no 759 0.215219470037447 236 24262820
SGTC_721 1187-1332 279 µM 0.788012302781448 0.230318405483944 no 760 0.215344754827334 246 25730
SGTC_1241 0364-0022 50.8 µM 0.787686329036341 0.230409293440977 no 761 0.215440102033851 239 4563895
SGTC_2929 9013348 24.6 µM 0.786316883528988 0.23079134104056 no 762 0.215840931822763 233 2995952
SGTC_3152 9099253 49.47 µM 0.785647235262741 0.230978288092066 no 763 0.216037091726026 250 25236131
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.785558165180349 0.231003160334242 no 764 0.21606319078262 251 616764
SGTC_621 3584-0052 32.1 µM 0.784514120002914 0.231294814615898 no 765 0.216369250004166 248 2273927
SGTC_400 oxethazaine 37.5 µM 0.784078869213073 0.231416462669046 no 766 0.216496916755201 244 4621 A local anesthetic.
SGTC_2240 6690706 185.951 µM 0.783407604380611 0.231604144105049 no 767 0.216693896020576 228 805876
SGTC_2868 9035608 32.47 µM 0.783301518010094 0.231633812949988 no 768 0.216725036011062 241 6462614
SGTC_2478 5763493 32.33 µM 0.782710666225962 0.231799093373703 no 769 0.216898518625379 240 1365576 YLR208W SEC13
SGTC_1774 st048371 48.465 µM 0.782055660246028 0.231982396569741 no 770 0.217090931628179 259 4242727
SGTC_1226 3909-7979 35.4 µM 0.781544812761062 0.232125413064626 no 771 0.217241065404602 256 6615510
SGTC_947 3447-0010 211 µM 0.781352125570697 0.232179370375981 no 772 0.217297710120676 251 748350
SGTC_1628 st004252 77.7 µM 0.779912423456177 0.232582744407017 no 773 0.217721212683373 239 692968
SGTC_677 0929-0063 136 µM 0.779258995974465 0.232765949409165 no 774 0.217913581813351 278 1539583
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.778729836172824 0.232914371556326 no 775 0.218069438324058 243 115019
SGTC_2164 5685496 200 µM 0.776225924318149 0.23361739732394 no 776 0.21880780087553 244 759046
SGTC_132 0417-1715 25.805 µM 0.77453459980677 0.234092937170155 no 777 0.219307357712512 244 6769098
SGTC_58 0957-0393 9 µM 0.773768141097004 0.234308614276179 no 778 0.219533957885755 248 6997992
SGTC_1685 st024049 53.0905 µM 0.773391755178698 0.234414567378019 no 779 0.219645283959004 246 1941139
SGTC_2552 juarezic acid 87.02 µM 0.771233700918289 0.235022573807595 no 780 0.220284210956467 233 1549512
SGTC_585 0kpi-0023 191 µM 0.770478228100236 0.235235625098535 no 781 0.22050813251389 211 64601
SGTC_2855 9016525 58.44 µM 0.769876340770659 0.235405439960139 no 782 0.220686624767574 245 43811474
SGTC_3276 9139060 49.47 µM 0.769226099479006 0.235588973281812 no 783 0.220879549559022 275 4870619
SGTC_2889 9059656 51.95 µM 0.768384035702165 0.235826766556354 no 784 0.221129530978891 254 3949838
SGTC_1090 efavirenz 20.7 µM 0.767879576588685 0.235969285849943 no 785 0.221279366028465 243 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1921 5740136 50 µM 0.767528241631216 0.236068572691635 no 786 0.221383754253477 238 1774243
SGTC_1076 itraconazole 331 nM 0.767041949296038 0.236206036296929 no 787 0.221528287304711 241 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1957 st077035 62.4 µM 0.766965100146359 0.236227763808867 no 788 0.221551132907677 255 705593
SGTC_1495 4469-0029 237 µM 0.766819313101514 0.236268985113187 no 789 0.221594475967676 249 793680
SGTC_1623 st003709 20.3 µM 0.764337221500259 0.236971404267116 no 790 0.22233315477146 253 16192618
SGTC_1956 st077085 54 µM 0.76232106253143 0.237542810689727 no 791 0.222934203004678 272 24208685
SGTC_353 1988-1175 58.3 µM 0.761599991175915 0.237747355396762 no 792 0.223149390051533 260 2788357
SGTC_2090 5301565 104.445 µM 0.761094865531524 0.237890700790653 no 793 0.223300203511415 248 2056344
SGTC_802 4112-3352 742 µM 0.75853793980674 0.238617036009156 no 794 0.224064504591826 225 704594
SGTC_2334 9017922 200 µM 0.757159492886107 0.239009108624973 no 795 0.224477157498205 253 3163164
SGTC_1430 4049-0248 69.1 µM 0.756448083405729 0.239211593025315 no 796 0.224690294179622 263 22774488
SGTC_1067 clotrimazole 1.36 µM 0.756261861722759 0.239264611710168 no 797 0.224746104725841 237 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2425 5628681 7.85 µM 0.754852441104867 0.239666092240976 no 798 0.225168762208082 269 5714958
SGTC_3050 9093513 49.47 µM 0.754669399466964 0.239718259531091 no 799 0.22522368580647 260 25236664
SGTC_962 1254-0300 21.5 µM 0.753824725866246 0.239959073713645 no 800 0.225477237423455 224 7340576
SGTC_2618 avocadyne 43.43 µM 0.753638606737762 0.240012153510548 no 801 0.225533127827257 254 3015189
SGTC_3300 9124615 50.48 µM 0.753328281055841 0.24010067033119 no 802 0.225626334111581 230 24824903
SGTC_1078 idebenone 36.1 µM 0.752132874367819 0.240441812548219 no 803 0.225985577999315 270 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2857 9024691 58.44 µM 0.751399080503376 0.240651351523179 no 804 0.226206257972118 251 16478292
SGTC_248 streptozotocin 5.23457 mM 0.750858249454171 0.240805852484164 no 805 0.226368984534758 269 5300 DNA alkylating agent.
SGTC_340 k038-0059 454 µM 0.749850142843078 0.241093985575771 no 806 0.22667248251223 258 23733424
SGTC_3112 9123419 49.47 µM 0.749678738910546 0.241142994215636 no 807 0.226724107770669 279 17015854
SGTC_1063 disulfiram 1.84 µM 0.74766126953004 0.241720245611502 no 808 0.227332249053307 274 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_178 4092-0806 87.505 µM 0.746457056142199 0.242065160068418 no 809 0.227695681917177 242 2169044
SGTC_2720 fluspirilene 36.88 µM 0.744690697992192 0.242571568211654 no 810 0.228229361896431 253 3396 An atypical antipsychotic.
SGTC_71 0417-1750 47.813 µM 0.744574529777683 0.242604893290465 no 811 0.228264485095963 233 6811472
SGTC_386 1509-0011 3.07 µM 0.743171954494809 0.24300744448231 no 812 0.228688790311227 243 3107280
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.742882880391644 0.243090456123515 no 813 0.228776295637332 260 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2323 6148992 148.28 µM 0.742841063327197 0.243102465743498 no 814 0.228788955594186 256 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2418 pentamidine 31.67 µM 0.742093703914185 0.243317157159812 no 815 0.229015282119726 249 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2924 9010168 62.78 µM 0.741635525808791 0.243448827087434 no 816 0.229154096534344 260 2993929
SGTC_2513 baicalein 25.65 µM 0.739200511591507 0.244149240060018 no 817 0.229892625119442 257 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1977 st070720 65.3 µM 0.738623628550092 0.244315335065945 no 818 0.230067786107294 238 682188
SGTC_430 0958-0115 16.4 µM 0.738121705277675 0.24445989733811 no 819 0.230220247534639 259 6833180
SGTC_2314 7727897 200 µM 0.736609507006976 0.244895714103601 no 820 0.230679925920745 244 900724
SGTC_1362 1611-0397 101 µM 0.736417072136203 0.244951203962909 no 821 0.230738459074002 258 27816
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.735417832224062 0.245239450095072 no 822 0.231042532468526 273 6708784 An antioxidant flavonoid
SGTC_906 1165-0455 526 µM 0.735150506959781 0.245316595090353 no 823 0.231123918706793 265 3252859
SGTC_2066 5222451 176 µM 0.734583127257302 0.245480373313561 no 824 0.231296708465878 254 2281147
SGTC_2181 6316240 54.2555 µM 0.734003375971504 0.245647783347548 no 825 0.231473340270246 260 12779990
SGTC_2058 5236698 133 µM 0.732538518804394 0.246071051198946 no 826 0.231919970624338 235 766665
SGTC_2383 9036125 200 µM 0.732161503370437 0.246180052400817 no 827 0.23203499905491 255 79580
SGTC_2149 5554786 194.827 µM 0.732119872219899 0.246192090220619 no 828 0.232047702778816 252 745063 YPR165W RHO1
SGTC_3022 9087993 49.47 µM 0.732076655665775 0.246204586800343 no 829 0.232060890697402 262 17173644
SGTC_3204 9114183 49.47 µM 0.73190036896791 0.246255565715441 no 830 0.232114690484506 246 17027248
SGTC_2981 9013952 38.96 µM 0.731664856546639 0.246323680465236 no 831 0.232186575815608 238 2996344
SGTC_1779 st039427 55 µM 0.730720706410978 0.24659684832667 no 832 0.232474882619147 272 1124498
SGTC_1818 st052136 56.3 µM 0.729910475035289 0.246831399226427 no 833 0.232722454478052 255 674169
SGTC_221 trifluoperazine 10.304 µM 0.728704724795349 0.247180668405865 no 834 0.233091151013578 275 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_928 2764-0428 58.7 µM 0.728553119740041 0.247224602478095 no 835 0.233137532029327 269 662578
SGTC_374 0880-0231 82.3 µM 0.728338926373522 0.247286681316552 no 836 0.233203069617976 264 6833587
SGTC_562 3772-2733 112 µM 0.727535363762576 0.247519649034467 no 837 0.23344902996094 254 2876874 YIL048W NEO1
SGTC_2304 7443016 91.4 µM 0.727304561999649 0.247586584421203 no 838 0.233519702051587 264 939854
SGTC_1953 st076800 12.1 µM 0.727211967411142 0.247613440722999 no 839 0.233548058086389 259 297591
SGTC_3259 9138485 49.47 µM 0.725816302756891 0.248018430244144 no 840 0.233975695670032 237 17646153
SGTC_3351 9150312 21.596 µM 0.725202086781038 0.248196773407948 no 841 0.234164031421491 269 4904905
SGTC_73 0327-0325 16.231 µM 0.723973444878255 0.248553725827686 no 842 0.234541019066856 225 53298
SGTC_3224 9130643 49.47 µM 0.721030900357928 0.249409722211283 no 843 0.235445251613119 265 17644395
SGTC_2185 6113692 200 µM 0.720400508537838 0.249593308954116 no 844 0.235639218499984 278 874150
SGTC_1612 st002233 45.4 µM 0.720056745891915 0.249693451952534 no 845 0.235745028841775 259 1035021
SGTC_830 4076-0286 57.8 µM 0.719825355498682 0.249760871312931 no 846 0.235816265689269 264 6866659
SGTC_2194 5927483 104.545 µM 0.719378671985056 0.249891047166323 no 847 0.235953817170273 230 760979
SGTC_433 pimozide 108 µM 0.71914088651957 0.249960359072176 no 848 0.23602705872975 259 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2703 st077852 53.4 µM 0.718124931295499 0.250256613974559 no 849 0.236340129533019 275 6281836
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.717574173077582 0.250417294139508 no 850 0.236509943474833 264 5377381
SGTC_336 4111-0029 111 µM 0.716601251588574 0.250701271279313 no 851 0.23681008599929 270 3131175
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.716360018323467 0.250771709023546 no 852 0.236884537922115 274 165521
SGTC_2091 4-phenylthiadiazole 200 µM 0.716011916090235 0.250873369924383 no 853 0.236991995538626 256 270010
SGTC_991 3996-0057 64.7 µM 0.715786356747786 0.25093925464921 no 854 0.237061639010117 255 715343
SGTC_3079 9117512 49.47 µM 0.715666103572263 0.250974383725894 no 855 0.237098772853135 315 7185044
SGTC_1014 4130-3005 69.3 µM 0.715557466339384 0.251006121721294 no 856 0.237132322473442 271 743608
SGTC_868 0527-0199 213 µM 0.714468434352209 0.251324396001983 no 857 0.237468784124539 258 2849450
SGTC_840 0245-0196 390 µM 0.713993007190932 0.251463408506588 no 858 0.237615751758846 257 3827528
SGTC_3228 9131799 49.47 µM 0.713933578057504 0.251480788142194 no 859 0.23763412645011 266 17015818
SGTC_3321 9137793 26.8275 µM 0.71317030349394 0.251704058881475 no 860 0.237870190008208 269 4904192
SGTC_1461 k072-0203 53.8 µM 0.712780464358434 0.251818133806605 no 861 0.237990808028559 268 5418714
SGTC_811 0416-0114 265 µM 0.710814679335506 0.252393778388028 no 862 0.238599541451673 256 6612453
SGTC_1653 st012112 65 µM 0.709223968979706 0.252860096343711 no 863 0.239092750764849 268 720429
SGTC_1684 st024538 14.6195 µM 0.707549731559658 0.253351389744482 no 864 0.239612459491079 267 6732859
SGTC_49 0717-0965 32.132 µM 0.706483780568686 0.25366444692781 no 865 0.239943667871505 288 5889349 YGL099W LSG1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.70631808780591 0.253713127167898 no 866 0.239995173730759 263 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_689 0833-0039 98 µM 0.702653051690504 0.254791161399994 no 867 0.241135996141581 305 5374726
SGTC_2776 terbinafine 19.92 µM 0.702272998534507 0.25490308735351 no 868 0.24125446444464 248 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_309 k408-0051 1.48 µM 0.701484622694558 0.255135346682965 no 869 0.241500313917981 276 3640463
SGTC_256 clotrimazole 625 nM 0.701474685445223 0.255138274950778 no 870 0.241503413647544 250 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1259 0671-0132 43 µM 0.700570892220148 0.255404674504958 no 871 0.241785424505943 257 X1259
SGTC_3258 9138477 49.47 µM 0.699144030016757 0.255825548115231 no 872 0.242231012274805 275 4970355
SGTC_1965 Pectolinarigenin 58.4 µM 0.698757373139994 0.255939660452377 no 873 0.242351836052141 282 5320438 An anti-inflammatory.
SGTC_1427 4048-4900 550 nM 0.696992259015622 0.256460927965132 no 874 0.242903819134398 282 24132586
SGTC_1224 0823-0416 294 µM 0.696906743336621 0.256486196205996 no 875 0.242930578697332 265 3598164
SGTC_1546 5-methoxyflavanone 78.7 µM 0.696874588496016 0.256495697679402 no 876 0.242940641001381 255 147795
SGTC_1681 tripelennamine 100 µM 0.696634959000742 0.256566511868452 no 877 0.243015636029456 250 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3331 9141060 1.957 µM 0.695828855594707 0.256804802504004 no 878 0.243268007993768 261 4906567 YPR165W RHO1
SGTC_550 4123-0385 25.7 µM 0.694995979038527 0.257051128439242 no 879 0.243528910729051 266 5731123
SGTC_444 curcumin 90.4 µM 0.694647696566035 0.257154170534452 no 880 0.243638056749637 260 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2465 5809242 33.21 µM 0.69411840407467 0.257310806972466 no 881 0.243803978906408 306 2731748
SGTC_1302 1159-0335 255 µM 0.693820930759487 0.257398861647883 no 882 0.243897257350206 266 649284
SGTC_1349 flufenamic acid 69 µM 0.693207277353428 0.257580557818328 no 883 0.244089740927226 274 3371 A non-steroidal anti-inflammatory.
SGTC_2942 9052777 62.25 µM 0.693061267788046 0.257623799487096 no 884 0.244135551551823 304 6469503
SGTC_2329 6138490 200 µM 0.691707212414249 0.258024991162803 no 885 0.244560608352286 276 720019
SGTC_2453 5731132 22.18 µM 0.691679781291433 0.258033122049499 no 886 0.244569223480547 285 1362040
SGTC_678 1218-2179 85.9 µM 0.691424866849985 0.258108687850351 no 887 0.244649290747801 294 6820081 YOR116C RPO31
SGTC_1333 1482-0047 286 µM 0.691260396545965 0.25815744884827 no 888 0.24470095748432 275 3811116
SGTC_549 1661-1316 519 µM 0.690258369754669 0.258454625849553 no 889 0.245015861286199 286 2857282
SGTC_3232 9132874 49.47 µM 0.68878409866912 0.258892181074374 no 890 0.245479571872135 253 3784940
SGTC_1734 st037168 69.4 µM 0.68834702524498 0.259021975578345 no 891 0.245617137541113 268 708907
SGTC_823 0417-1665 178 µM 0.687126829611267 0.259384506201799 no 892 0.24600140425304 288 3429856
SGTC_2511 berberine 10.47 µM 0.686842128504855 0.259469131050762 no 893 0.246091109342693 285 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3252 9135871 49.47 µM 0.686236033251636 0.259649334905952 no 894 0.24628213937658 290 17682838
SGTC_125 0133-0007 11.75 µM 0.68430945466384 0.260222572792404 no 895 0.246889888988253 277 26541
SGTC_2082 5219693 150 µM 0.682493941774504 0.260763360246649 no 896 0.247463336117948 271 2834649
SGTC_3094 9117742 49.47 µM 0.682388560719149 0.26079476788524 no 897 0.247496643575264 298 17149698
SGTC_1615 st002656 86.5 µM 0.681422136524666 0.261082890488054 no 898 0.247802209899692 270 1584458
SGTC_1949 st076024 69.1 µM 0.680782586111692 0.261273651276931 no 899 0.248004535178648 281 2921930
SGTC_2683 piperine 63.03 µM 0.679517355778464 0.261651246501635 no 900 0.248405057262484 282 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_657 3534-0529 86.7 µM 0.678965642499985 0.261815987401321 no 901 0.248579815835939 280 1049549
SGTC_1321 1326-2144 215 µM 0.677712574812003 0.262190349400935 no 902 0.248976975919469 287 3513030
SGTC_1116 jasmonic acid 1.58368 µM 0.677651007988183 0.26220874995019 no 903 0.248996498237248 289 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1376 2910-0861 41.3 µM 0.676098075303155 0.262673095483837 no 904 0.249489189293506 290 1112859
SGTC_1046 2001-0062 216 µM 0.675382361147113 0.262887244162084 no 905 0.249716434558738 287 739778
SGTC_1364 1653-0028 37.6 µM 0.674759251778329 0.263073757245248 no 906 0.249914366495193 265 5718652
SGTC_3246 9135460 32.98 µM 0.674422051146202 0.263174718487473 no 907 0.250021513663207 283 41446951
SGTC_2390 9097792 176.6 µM 0.67356842662198 0.263430390660228 no 908 0.250292865993738 263 4497149
SGTC_1888 azatryptophan 97.5 µM 0.672134863470918 0.2638600474395 no 909 0.250748921757013 262 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1625 st003711 30.1 µM 0.671432406761623 0.264070712836981 no 910 0.250972553032692 285 24207034 YER133W GLC7
SGTC_3298 9116858 71.43 µM 0.66856138838392 0.264932615620904 no 911 0.251887654943854 306 2506942
SGTC_456 gingerol 170 µM 0.668392436591319 0.264983380811027 no 912 0.251941561073727 306 442793 A herb.
SGTC_981 1488-1094 54.9 µM 0.667310197691229 0.265308679893103 no 913 0.252287006950413 280 3449522
SGTC_1193 1488-0126 41.5 µM 0.666624689778497 0.265514834496459 no 914 0.252505947167753 274 1384710
SGTC_2824 7998404 51.95 µM 0.665916674733483 0.265727843006697 no 915 0.252732180856864 300 837851
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.663738100757555 0.266383816675643 no 916 0.253428974589466 268 6312947
SGTC_1698 5-fluorocytosine 1.055 µM 0.662581429426849 0.266732425774877 no 917 0.253799333518958 281 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3165 9101544 49.47 µM 0.662084079578563 0.266882392873574 no 918 0.253958669143027 283 5002184
SGTC_169 k015-0017 16.025 µM 0.660487413115231 0.267364127276974 no 919 0.254470546603945 328 1840002
SGTC_2507 purpurin 79.67 µM 0.658828304489883 0.26786516557566 no 920 0.255003014667435 290 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_364 0083-0097 67.7 µM 0.658757342286373 0.267886606168374 no 921 0.255025802001656 279 5207356
SGTC_1534 6-azauridine 81.6 µM 0.657009906250126 0.268414850843098 no 922 0.255587273399206 279 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3193 9111931 49.47 µM 0.65575729870841 0.268793832390313 no 923 0.255990147619068 321 17087244
SGTC_1441 4106-0040 13 µM 0.655132171598415 0.268983067642942 no 924 0.256191330140359 278 2904180
SGTC_1210 3013-0140 750 nM 0.654856967847039 0.269066397098464 no 925 0.256279924151344 278 905973
SGTC_1301 naphtanilide LB 4.81 µM 0.65280759434964 0.269687337874701 no 926 0.256940163523998 289 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2300 7976697 71.57 µM 0.649611385316326 0.270657189474009 no 927 0.257971638457539 272 2236109
SGTC_675 1309-0189 238 µM 0.648902600706031 0.270872497446415 no 928 0.258200666813242 267 4246530
SGTC_758 0868-0029 16 µM 0.645715422562345 0.271841723806194 no 929 0.259231835362978 268 762687
SGTC_3325 9138760 55.175 µM 0.640872117262742 0.273317877129782 no 930 0.260802886418452 276 43844959
SGTC_87 0100-0052 35.5 µM 0.640301532297915 0.273492042326792 no 931 0.260988292379955 304 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2553 4-methylesculetin 85.09 µM 0.638631106517579 0.274002238252616 no 932 0.26153147014517 282 5319502
SGTC_2228 7354201 200 µM 0.636543995678456 0.274640362031912 no 933 0.262210957369197 316 753451
SGTC_983 1491-0821 12.2 µM 0.634086682389978 0.275392611676764 no 934 0.263012126760641 275 46495113
SGTC_3154 9100113 49.47 µM 0.631124748881134 0.276300684516776 no 935 0.263979480073048 304 25237525
SGTC_268 camptothecin 39.6153 µM 0.630144092145462 0.276601658716777 no 936 0.264300156962782 301 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_261 5-fluorouridine 15.376 µM 0.629882323577974 0.276682025496142 no 937 0.264385789380853 266 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_473 2-arachidonoylglycerol 10 µM 0.628665539198294 0.277055746239397 no 938 0.264784021676656 284 5282280 An endocannabinoid.
SGTC_1235 benzylparaben 21.5 µM 0.628049998286592 0.277244896314039 no 939 0.264985593573709 312 7180
SGTC_32 0928-0142 34.1 µM 0.627140471917266 0.277524500992118 no 940 0.265283579884078 303 2244242
SGTC_2818 7996756 12.99 µM 0.627069540106592 0.277546312491042 no 941 0.265306826280442 316 2241621
SGTC_1849 st056239 19.2 µM 0.627046770253858 0.27755331438782 no 942 0.26531428883593 290 5393181
SGTC_1446 4239-0190 62 µM 0.626520729860473 0.277715099695854 no 943 0.265486722141688 300 1340085
SGTC_733 4069-0007 56.1 µM 0.622260175775373 0.279027140484221 no 944 0.26688540154106 298 5717425 YNL287W SEC21
SGTC_1565 sinapyl alcohol 95.1 µM 0.620445360424295 0.279586928302977 no 945 0.267482308204136 298 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1696 st025591 34.7925 µM 0.61811688621778 0.280305953993157 no 946 0.268249145967334 291 2787147
SGTC_2706 st078239 82.5 µM 0.617851114462433 0.280388080405374 no 947 0.268336743009353 300 15434492
SGTC_2203 7227154 166.4 µM 0.615886130931641 0.280995643285948 no 948 0.268984837860775 292 896304
SGTC_1218 1348-1416 30.7 µM 0.612774773646312 0.281958958255559 no 949 0.27001263655025 293 6787668
SGTC_878 0828-0289 13.7 µM 0.612734843001648 0.281971331612419 no 950 0.270025839909753 308 745350 YLR208W SEC13
SGTC_3332 9141069 11.198 µM 0.611394144185185 0.282386927308166 no 951 0.270469339203648 297 17332883
SGTC_3211 9128781 49.47 µM 0.610647451424639 0.282618518080904 no 952 0.27071650072297 308 17194361
SGTC_2496 diffractaic acid 79.83 µM 0.610463762888041 0.282675504055974 no 953 0.270777320436897 302 94870 An apoptosis inducer which activates caspases.
SGTC_124 0136-0217 7.121 µM 0.610374609008146 0.282703164390488 no 954 0.270806841958394 291 3976905
SGTC_2585 alliin 100 µM 0.609954869658292 0.28283340761268 no 955 0.270945851820451 324 87310 A garlic compound which reacts with lipids.
SGTC_2944 9067346 25.62 µM 0.607226256734908 0.283680785768296 no 956 0.271850384746858 312 6473075
SGTC_548 1436-0017 110 µM 0.606194589472866 0.284001489330449 no 957 0.272192772591636 302 9677137
SGTC_1109 tnp00067 928.257 nM 0.604891755052559 0.284406735459644 no 958 0.272625460909475 297 676295
SGTC_1916 st067606 49.2 µM 0.60383645241242 0.284735189333195 no 959 0.272976190777312 292 19590279
SGTC_1158 4092-0494 91.8 µM 0.602588512287293 0.285123833444047 no 960 0.273391232207574 296 1148199
SGTC_1778 st046819 58.9 µM 0.602555741702653 0.285134042544032 no 961 0.273402135297035 315 671715
SGTC_2592 piperlongumine 83.33 µM 0.60244426139172 0.285168773581079 no 962 0.273439227483213 308 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1962 st076595 64.5 µM 0.601568774818466 0.285441596354685 no 963 0.273730609546426 307 279619
SGTC_2202 7226349 200 µM 0.601238208256833 0.285544641196632 no 964 0.273840669628775 282 844334
SGTC_1752 st044819 83.042 µM 0.600421058538894 0.285799440628414 no 965 0.274112828411555 299 441209 YML126C ERG13
SGTC_3031 9088762 49.47 µM 0.600024348729336 0.285923179623654 no 966 0.274245004213677 297 205253
SGTC_1062 mesoridazine 14.2 µM 0.599324325414858 0.28614158818063 no 967 0.274478314773146 293 4078 A neuroleptic.
SGTC_2139 5578692 56.4705 µM 0.597849150590206 0.2866021047307 no 968 0.274970295800811 300 650991 YMR113W FOL3
SGTC_2326 6164455 177.58 µM 0.597229721676791 0.286795581306721 no 969 0.275177009081118 317 2888790
SGTC_854 0422-0053 192 µM 0.595678552100832 0.287280355437111 no 970 0.275694994516069 312 3596728
SGTC_2537 larixol 68.93 µM 0.595231082248629 0.287420271497569 no 971 0.27584450812343 306 6708759
SGTC_2029 5175081 200 µM 0.593800299167609 0.287867868706904 no 972 0.276322844470917 288 1380876
SGTC_2815 7968870 71.43 µM 0.593137566771839 0.288075305248047 no 973 0.276544545564685 311 2977326 YHR190W ERG9
SGTC_2497 7-hydroxyflavone 100 µM 0.592674763755218 0.288220205319847 no 974 0.276699416812752 344 5281894
SGTC_1803 st050068 52.4 µM 0.591607210240739 0.288554579181315 no 975 0.277056822257245 322 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1545 lovastatin 49.4 µM 0.590735753515176 0.288827667993494 no 976 0.277348744009412 288 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1640 st009078 66.4 µM 0.586867994771855 0.290041175206136 no 977 0.278646183162248 318 690618
SGTC_2591 skatole 100 µM 0.586531654087604 0.290146814768891 no 978 0.278759148125307 327 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_656 4090-1979 187 µM 0.58642725732694 0.290179607891364 no 979 0.278794215844891 309 22330961
SGTC_301 4119-0100 24.5 µM 0.586067092974135 0.290292756087238 no 980 0.278915214454041 326 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1087 pterostilbene 9.05 µM 0.586016221536241 0.290308739376945 no 981 0.278932306969568 319 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2837 9008476 45.46 µM 0.583717512402685 0.291031400155768 no 982 0.279705191527077 315 2992805
SGTC_499 genistein 192 µM 0.580340358206354 0.292094620622734 no 983 0.280842558266587 330 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2113 5491891 107.031 µM 0.579674523793947 0.292304456663328 no 984 0.281067063304683 308 789979
SGTC_1149 3909-7961 23.3 µM 0.578601603659883 0.292642732174391 no 985 0.281429011210171 300 735261
SGTC_706 4262-0057 46.9 µM 0.577838658906108 0.292883387712409 no 986 0.281686526169427 325 883298
SGTC_652 0437-0092 114 µM 0.577607279442499 0.292956389847383 no 987 0.281764645584085 293 3091274
SGTC_52 0329-0193 875 nM 0.576504020632558 0.293304593188073 no 988 0.282137276509955 342 3739292
SGTC_1845 st056753 3.01 µM 0.57648084160068 0.293311910859612 no 989 0.282145107882415 303 5375839
SGTC_311 1315-0136 58 µM 0.576401277218366 0.293337030154451 no 990 0.282171990660279 314 6759207
SGTC_1663 st014140 55.4 µM 0.574202908927816 0.294031471612822 no 991 0.282915250544898 312 4207120
SGTC_92 0063-0024 660.874 µM 0.571793542599841 0.294793436861657 no 992 0.283730926268497 311 3594437
SGTC_2253 7938677 135.83 µM 0.571550499726007 0.294870350008873 no 993 0.283813269386131 302 2301972
SGTC_3097 9117246 49.47 µM 0.570810043396472 0.295104731201624 no 994 0.284064207075244 293 16423892
SGTC_2053 5265679 138 µM 0.570399203180517 0.295234813977602 no 995 0.284203484946849 322 764595
SGTC_593 1203-0218 61.7 µM 0.569987363210918 0.295365239786612 no 996 0.284343134504177 332 3666956
SGTC_1763 st044482 94.5 µM 0.567558319106496 0.296135033707455 no 997 0.285167458057254 326 88505
SGTC_2932 9016711 44.54 µM 0.567439579874512 0.29617268721753 no 998 0.285207782737653 328 7117328
SGTC_1348 1493-0373 93.8 µM 0.566968014517174 0.296322247432201 no 999 0.285367956476672 340 3010129
SGTC_2394 5221648 200 µM 0.566371277253071 0.296511556405393 no 1000 0.285570707985713 319 788586
SGTC_1958 st076513 41.9 µM 0.56630243796858 0.296533398549818 no 1001 0.285594101699063 333 732122 YGL099W LSG1
SGTC_2037 5169046 200 µM 0.564908411466632 0.296975870336937 no 1002 0.286068031051963 291 5718022
SGTC_2677 mitomycin C 100 µM 0.563517973910567 0.297417503593401 no 1003 0.286541112190301 332 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3303 9125618 40.5795 µM 0.563250091344803 0.297502623382072 no 1004 0.286632298919897 323 22695467
SGTC_2723 salbutamol 83.58 µM 0.563246820469042 0.297503662772841 no 1005 0.286633412404991 321 9884233 β2-adrenoceptor agonist
SGTC_304 1310-0298 97 µM 0.562855660922604 0.297627974042673 no 1006 0.286766587349554 337 1550234
SGTC_3256 9138902 49.47 µM 0.561066522424313 0.298196867709177 no 1007 0.287376094535266 346 17228773
SGTC_789 1309-1135 70.6 µM 0.560740373605874 0.29830062683224 no 1008 0.287487269909242 305 3092424
SGTC_957 1187-1561 14.1 µM 0.560394634840082 0.298410636133445 no 1009 0.2876051451729 304 1538454
SGTC_441 propafenone 146 µM 0.559483864508663 0.298700519018482 no 1010 0.287915770118235 325 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3020 9089140 49.47 µM 0.559404955859321 0.298725640340155 no 1011 0.287942689950894 312 17217859
SGTC_414 piperonyl butoxide 100 µM 0.557612317283451 0.299296602487323 no 1012 0.288554571859624 325 5794 A potent inhibitor of cytochrome P450.
SGTC_1838 st055369 84.5 µM 0.557591315306116 0.299303294629312 no 1013 0.288561744100681 297 676036
SGTC_2100 5377183 190 µM 0.557018462488866 0.299485856582137 no 1014 0.288757407514788 317 2844202
SGTC_2007 4011539 71.82 µM 0.55689696416877 0.299524583260892 no 1015 0.288798914467792 314 45595301
SGTC_578 3460-0051 92 µM 0.553952286069757 0.300463870604049 no 1016 0.28980575019218 346 2876744
SGTC_2379 9035213 200 µM 0.55284069537759 0.300818789108785 no 1017 0.290186249712853 313 646551
SGTC_2870 9038528 12.99 µM 0.552222184655303 0.301016354538434 no 1018 0.29039806836353 321 6463316
SGTC_380 3970-0968 6 µM 0.552072454382509 0.301064190352255 no 1019 0.290449356713433 308 2891601
SGTC_145 3737-0113 38.366 µM 0.551485257026731 0.301251821165525 no 1020 0.290650535194224 343 6849351
SGTC_736 0958-0254 92.6 µM 0.550544882489282 0.301552414529914 no 1021 0.290972850693606 342 6812352
SGTC_2423 st077119 87.2 µM 0.550495014579473 0.301568358714486 no 1022 0.290989947694567 302 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_970 1315-0089 19.5 µM 0.549762340625724 0.301802659054658 no 1023 0.291241195936597 313 6811083 YLR033W RSC58
SGTC_1179 1021-1431 9.29 µM 0.548720722513113 0.302135896799217 no 1024 0.291598561400211 347 2840958
SGTC_3093 9117344 49.47 µM 0.547193704998277 0.30262472338131 no 1025 0.292122830247454 308 24824913
SGTC_525 k781-2675 26.7 µM 0.54704129999344 0.30267353049022 no 1026 0.292175179317249 321 3651118 YDL195W SEC31
SGTC_2241 6772625 37.8075 µM 0.545618759557365 0.30312926349852 no 1027 0.292664013212173 314 2285411
SGTC_1754 st042065 16.137 µM 0.542502717828307 0.304128606819908 no 1028 0.29373611783957 323 1126236 YIL048W NEO1
SGTC_2735 sertaconazole 140 nM 0.540023568247179 0.304924739975629 no 1029 0.294590389511523 352 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1043 0916-0009 19.3 µM 0.539808133894895 0.304993966448878 no 1030 0.294664678529602 349 3101130
SGTC_2689 tacrolimus 100 µM 0.539164668581849 0.305200775551921 no 1031 0.29488661846589 312 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_643 k048-0106 28.4 µM 0.539059199397891 0.305234679176968 no 1032 0.294923003569262 330 6763920
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.538208558954017 0.305508183102864 no 1033 0.295216535887557 331 5106787 A p450 inhibitor.
SGTC_2877 9040724 71.43 µM 0.537606920263629 0.305701691790762 no 1034 0.295424225801906 323 6463895
SGTC_3247 9135149 49.47 µM 0.536583450432859 0.306031001248467 no 1035 0.295777689131534 343 8934436 YOR116C RPO31
SGTC_1853 st056710 91.2 µM 0.536176991548315 0.306161826112945 no 1036 0.295918116775983 355 269167
SGTC_3015 9080845 49.47 µM 0.536042993670558 0.306204960751432 no 1037 0.295964418466208 326 5296973
SGTC_3002 9075603 71.4286 µM 0.535646957821005 0.306332462526566 no 1038 0.296101284320373 328 20105405
SGTC_1848 st056003 16.4 µM 0.534399357184487 0.306734274627467 no 1039 0.296532631818713 305 146492
SGTC_2791 5663188 71.43 µM 0.534115563680955 0.306825707857301 no 1040 0.296630791231761 352 54690634
SGTC_2459 5811157 9.22 µM 0.53210260869436 0.307474590937646 no 1041 0.297327465356147 330 2870684 YBR192W RIM2
SGTC_2068 5226020 147 µM 0.531568550240688 0.307646847839199 no 1042 0.29751242584218 331 1810509
SGTC_2261 9010538 184.68 µM 0.530767876464607 0.30790517914807 no 1043 0.297789821597327 352 6457250
SGTC_2544 sphondin 68.51 µM 0.530746789484132 0.307911983989668 no 1044 0.297797128837086 304 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2652 actinonin 100 µM 0.530582029266516 0.3079651549565 no 1045 0.297854225764161 319 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2564 betulinic acid 100 µM 0.529983214098128 0.308158436898176 no 1046 0.298061784551114 333 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1883 5-benzylidenerhodanine 20 µM 0.529658659787061 0.308263216816771 no 1047 0.29817430773075 313 1273210
SGTC_1059 3448-6867 171 µM 0.528932578050632 0.308497683412504 no 1048 0.298426110751454 328 3934407
SGTC_793 0488-0545 106 µM 0.528414334802156 0.308665082507337 no 1049 0.298605895154232 335 292548
SGTC_1462 k081-0014 26.5 µM 0.524508645277823 0.309927946707448 no 1050 0.299962404170147 311 3270634
SGTC_3006 9075424 71.4286 µM 0.522472475654935 0.310587212753861 no 1051 0.300670702832318 321 7465181
SGTC_1485 3909-9022 254 µM 0.522076850409712 0.310715378033491 no 1052 0.300808411928699 338 714516
SGTC_2106 5357045 167.29 µM 0.521040993546087 0.311051059152254 no 1053 0.301169107327113 329 668842
SGTC_133 0724-0033 378.92 µM 0.519771944500472 0.311462523164113 no 1054 0.301611267893005 329 280309
SGTC_3122 9126309 49.47 µM 0.518662765725604 0.311822345388119 no 1055 0.301997965602913 353 17591206
SGTC_2751 anetholtrithion 17.25 µM 0.518019361478622 0.312031150787258 no 1056 0.302222380361524 344 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_842 0271-0008 11.1 µM 0.516701858110888 0.312458911519013 no 1057 0.30268214938942 313 1221709
SGTC_646 4092-0839 27.3 µM 0.514649377983747 0.313125804610617 no 1058 0.303399026782027 356 877796
SGTC_707 0865-0008 204 µM 0.513189775711206 0.313600431839691 no 1059 0.303909288617704 332 723043
SGTC_2030 5175110 200 µM 0.511994151607543 0.313989449862665 no 1060 0.304327551338104 350 2831986
SGTC_1130 3454-2858 15.9 µM 0.511751114842816 0.314068551595071 no 1061 0.304412603726076 354 715628 YIL048W NEO1
SGTC_117 lucigenin 22.078 µM 0.510807079849184 0.314375889839348 no 1062 0.304743075587635 352 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3327 9140648 26.9345 µM 0.509442069101573 0.314820507725824 no 1063 0.305221197358072 365 8029710
SGTC_1555 citronellol 128 µM 0.506206573365578 0.31587546084177 no 1064 0.30635582046353 346 8842 A terpine precursor.
SGTC_1234 0326-0494 15.5 µM 0.503029033351938 0.316912978920601 no 1065 0.307471929884143 366 1547813
SGTC_2145 5634607 200 µM 0.501495244946424 0.317414301917199 no 1066 0.308011311755519 342 308662
SGTC_2162 5663267 200 µM 0.499934909725044 0.317924645709679 no 1067 0.308560455127799 368 6456493
SGTC_616 4092-0450 108 µM 0.499911185527226 0.317932407931093 no 1068 0.308568807916608 355 787165
SGTC_355 1311-2252 105 µM 0.498883167924432 0.31826883752187 no 1069 0.308930846298269 346 5338538
SGTC_442 cape 100 µM 0.498262272903409 0.318472104615715 no 1070 0.30914959773548 334 5281787
SGTC_2046 4110841 106 µM 0.497666327825174 0.318667255063984 no 1071 0.309359622562084 330 44119630 YMR134W ERG29
SGTC_1101 ebselen 5.29 µM 0.497495778386241 0.318723113094082 no 1072 0.309419739596312 356 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1484 3473-2379 286 µM 0.496467569674403 0.319059957303545 no 1073 0.309782281293336 337 671917
SGTC_483 fpl-64176 144 µM 0.495897453651702 0.319246793429532 no 1074 0.309983381395109 357 3423
SGTC_488 nitrendipine 139 µM 0.495606266781157 0.319342237734881 no 1075 0.31008611525283 340 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2038 4100038 30.985 µM 0.493752435061055 0.319950161319592 no 1076 0.310740514414798 332 3596803
SGTC_3172 9105863 49.47 µM 0.493678037309243 0.319974568544627 no 1077 0.310766789202141 337 2348785
SGTC_1352 1496-0991 99 µM 0.493634533046542 0.319988841088716 no 1078 0.310782153893824 370 3000039
SGTC_551 k048-0028 34.9 µM 0.491757580099032 0.320604870872423 no 1079 0.311445363853894 345 6836383
SGTC_426 0988-0037 14.6 µM 0.491634208467679 0.320645379687154 no 1080 0.311488977942588 356 5383008
SGTC_2301 7769476 200 µM 0.491282022260918 0.320761031036328 no 1081 0.311613496648823 335 977820
SGTC_1951 sophoraflavanone G 9.2 µM 0.48963840929035 0.32130099264262 no 1082 0.312194896015153 348 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_814 3342-0569 96 µM 0.489174778862059 0.321453373427912 no 1083 0.312358981870151 352 4346283
SGTC_174 3553-0389 74.3 µM 0.488469644662691 0.321685186536289 no 1084 0.312608610919188 315 738071
SGTC_826 1683-5028 118 µM 0.487925547825534 0.321864106024717 no 1085 0.312801288890209 346 722377
SGTC_173 1273-0061 2.693 µM 0.484767779368659 0.322903313458224 no 1086 0.313920540442001 348 2847414 YPL266W DIM1
SGTC_1052 3253-3998 198 µM 0.483703835144228 0.3232537649135 no 1087 0.314298035516173 321 5450317
SGTC_2284 7945075 39.21 µM 0.483606641299053 0.323285787316705 no 1088 0.31433253028416 361 1245402
SGTC_2471 5466956 24.79 µM 0.482177211497751 0.323756891894044 no 1089 0.314840031952667 331 724419
SGTC_1512 0259-0544 12.2 µM 0.480283541692953 0.324381433451412 no 1090 0.315512895082235 348 18476
SGTC_532 1548-0774 215 µM 0.480226928643552 0.324400112330449 no 1091 0.315533020396416 368 5932993
SGTC_903 1134-0042 114 µM 0.479695604967437 0.324575438504886 no 1092 0.31572192675669 344 701009
SGTC_3141 9094609 49.47 µM 0.478529810168629 0.324960263658747 no 1093 0.316136581111829 361 25236309 YDL196W YDL196W
SGTC_3294 9122953 26.2835 µM 0.477692720526316 0.325236699558365 no 1094 0.316434463106648 345 16459826
SGTC_2690 usnic acid 100 µM 0.476510213418066 0.325627368147299 no 1095 0.31685546639668 362 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_591 4299-0174 154 µM 0.476065425434975 0.325774363764321 no 1096 0.317013883926782 370 5509088
SGTC_2340 7987427 183.45 µM 0.475606802099315 0.325925960121851 no 1097 0.317177264242793 325 2239331
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.475516019980271 0.325955971250476 no 1098 0.317209608758547 355 6710655
SGTC_924 2046-0044 21.3 µM 0.472771102122207 0.326863929267263 no 1099 0.31818824654853 331 3623589
SGTC_236 1509-0011 5.31 µM 0.472701643189172 0.326886918076047 no 1100 0.318213027054983 370 3107280
SGTC_1126 isoteolin 1.0172 µM 0.472004002679081 0.327117852441932 no 1101 0.31846196578399 332 133323
SGTC_832 4083-0019 164 µM 0.471949807833744 0.327135794901138 no 1102 0.318481307537754 337 1990758
SGTC_637 1181-0519 7.26 µM 0.471758778257918 0.327199042854043 no 1103 0.318549488575822 353 6252091 YGR060W ERG25
SGTC_923 1900-2434 73.3 µM 0.470121291882753 0.327741401381853 no 1104 0.319134181485394 364 5910570
SGTC_2563 tomatine 8.54 µM 0.46645926782299 0.328955629762926 no 1105 0.320443398361303 395 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2980 9014342 25.29 µM 0.466343393331608 0.328994080180521 no 1106 0.320484861466494 368 2996599
SGTC_1026 k007-1105 30.6 µM 0.466147973663358 0.329058930025713 no 1107 0.320554793116585 339 7066794
SGTC_1338 1486-1223 76 µM 0.464319702789433 0.329665889116779 no 1108 0.321209354925064 355 3444526
SGTC_1609 st001574 46.4 µM 0.463991509877318 0.329774891915468 no 1109 0.321326914218586 384 3960012
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.462537009911513 0.33025814930316 no 1110 0.321848134086843 377 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2913 7966556 36.57 µM 0.462160214586137 0.330383385721155 no 1111 0.321983215881192 356 2976516
SGTC_3118 9124250 49.47 µM 0.46183961731241 0.33048995841147 no 1112 0.322098169098403 369 1504786
SGTC_960 1222-0186 7.7 µM 0.461760118508748 0.330516387467934 no 1113 0.322126676788558 352 3126296
SGTC_215 1287-0124 461.5 µM 0.459715510035009 0.331196399392156 no 1114 0.322860217616316 365 5560863
SGTC_542 3381-0244 89.3 µM 0.459332903782089 0.33132371152336 no 1115 0.322997561325992 377 1112843
SGTC_2733 amorolfine 100 µM 0.458630355400554 0.331557535075141 no 1116 0.323249817125923 381 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3206 9114350 49.47 µM 0.458447100445656 0.331618537154611 no 1117 0.323315629703102 335 17087243
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.458209807826599 0.33169753397727 no 1118 0.323400857108193 350 688667
SGTC_2516 gossypol 71.55 µM 0.458189376507027 0.331704336095245 no 1119 0.323408195773812 347 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2892 9047358 58.44 µM 0.457991205084328 0.331770315397922 no 1120 0.323479379949033 368 6466771
SGTC_78 0336-0123 156.75 µM 0.456297857432023 0.332334312130443 no 1121 0.324087902224547 340 6765896
SGTC_2190 6049624 200 µM 0.456205511651849 0.332365080315767 no 1122 0.324121101188808 359 2265554
SGTC_266 formosanin C 406 nM 0.452944399557794 0.333452355485722 no 1123 0.325294389337381 336 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_36 0335-0881 14.2 µM 0.452575630636139 0.333575393666483 no 1124 0.325427174946481 346 23828853
SGTC_3146 9095609 49.47 µM 0.451420111846801 0.333961043477699 no 1125 0.325843395407847 348 17173999
SGTC_394 menadione 8.33 µM 0.450435296189584 0.334289860277631 no 1126 0.326198299649441 363 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1318 1280-3875 124 µM 0.450234952160109 0.334356768052539 no 1127 0.326270518177883 354 373245
SGTC_1080 nisoldipine 24.4 µM 0.448545128549832 0.334921318199035 no 1128 0.326879912224659 376 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3223 9129970 49.47 µM 0.447836949437872 0.335158023553914 no 1129 0.327135437387903 355 17248386
SGTC_2022 5136654 200 µM 0.445878302566528 0.335813032286219 no 1130 0.327842578056758 386 1713771
SGTC_1929 genistein trimethyl ether 50.5 µM 0.445643184760293 0.335891693737207 no 1131 0.327927505462061 354 136420
SGTC_537 1334-0398 209 µM 0.444358536796444 0.336321614829698 no 1132 0.328391692945756 364 5846986
SGTC_1591 genipin 88.4 µM 0.444028211491715 0.33643219633342 no 1133 0.328511093701105 361 442424 A DNA cross-linking agent.
SGTC_638 3970-0837 4.09 µM 0.443410124668053 0.336639148458454 no 1134 0.328734556967172 348 4118451 YLR208W SEC13
SGTC_573 3702-0553 84.7 µM 0.44269722634541 0.336877907481348 no 1135 0.328992374468477 344 1222756
SGTC_1092 toremifene 6.32 µM 0.442071777040866 0.33708743282781 no 1136 0.329218633320945 384 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1806 st050005 60.3 µM 0.441287266933029 0.337350314964194 no 1137 0.329502521522059 349 5194765
SGTC_1775 st081588 35.1725 µM 0.440614669306553 0.337575759494731 no 1138 0.329745990575508 356 1426443 YGL099W LSG1
SGTC_1311 1190-0148 100 µM 0.438960578394646 0.338130433570431 no 1139 0.330345050501646 373 1961333
SGTC_2844 9010103 25.97 µM 0.43723262914976 0.33871025037833 no 1140 0.330971324283007 376 2480525
SGTC_2256 7954252 200 µM 0.436858663109054 0.338835785815293 no 1141 0.33110692599581 379 2972920
SGTC_66 0109-0187 42.4 µM 0.43593608058171 0.339145561063455 no 1142 0.331441553149335 334 759417
SGTC_423 5-fluorouracil 457 µM 0.435895803762213 0.339159087277988 no 1143 0.331456164902517 346 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2803 7707263 71.43 µM 0.431507610974942 0.340634017884689 no 1144 0.333049659885498 362 2199229
SGTC_2596 sinensetin 100 µM 0.431419878478641 0.340663530910561 no 1145 0.333081549275579 353 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1044 1222-0021 1.78 µM 0.430671365684353 0.340915368677412 no 1146 0.333353671026705 347 4306703
SGTC_305 1682-2595 20.8 µM 0.42876574821576 0.34155683512447 no 1147 0.334046853788443 366 226033
SGTC_94 0334-0113 514.748 µM 0.428273248889685 0.341722694139113 no 1148 0.33422609636603 354 6795178
SGTC_299 1273-0059 1.44 µM 0.428255248288195 0.34172875678136 no 1149 0.334232648308113 356 2848077
SGTC_2732 terfenadine 20 µM 0.427643751565034 0.341934734465337 no 1150 0.334455253700531 392 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_603 3794-0023 45.9 µM 0.426932053605968 0.342174523370356 no 1151 0.334714409022405 362 3802260
SGTC_2939 9044578 71.43 µM 0.426640147331928 0.34227289233456 no 1152 0.334820725581216 374 2653634
SGTC_2802 7925815 54.55 µM 0.426536309711238 0.342307886966569 no 1153 0.334858547963357 356 1262923
SGTC_2675 theaflavin digallate 100 µM 0.424772768697961 0.34290242985206 no 1154 0.335501165331006 352 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_131 0141-0277 33.849 µM 0.424670557884055 0.342936900148459 no 1155 0.335538424747482 367 1547771
SGTC_1114 scopoletin 1.73284 µM 0.424334966239817 0.343050086635273 no 1156 0.335660771009975 380 5280460 A coumarin with genotoxic properties.
SGTC_2895 9054447 58.44 µM 0.424283642226389 0.343067398155578 no 1157 0.335679483683343 365 2697450
SGTC_1134 3477-0009 42.5 µM 0.423832676163273 0.343219522557956 no 1158 0.335843922881736 407 3973534
SGTC_641 4092-0595 30 µM 0.421974011058422 0.343846774080876 no 1159 0.336521993577173 373 786260
SGTC_1563 conessine 56.1 µM 0.421387157973692 0.344044911268734 no 1160 0.336736197549818 391 441082 An anti-amoebic, histamine inhibitor.
SGTC_2031 5180455 200 µM 0.421030749189161 0.344165265247658 no 1161 0.33686631419443 361 29949
SGTC_629 3448-6466 76.7 µM 0.420946872302231 0.344193591527836 no 1162 0.336896938554383 384 573744
SGTC_244 nsc-207895 1.295 µM 0.420319933585217 0.344405344298502 no 1163 0.337125874904842 357 42640
SGTC_2878 9043973 25.97 µM 0.420067342116705 0.344490672555925 no 1164 0.337218129634592 372 6465167
SGTC_2822 7994718 71.43 µM 0.417541809577656 0.345344260569004 no 1165 0.338141074812599 396 1018011
SGTC_1716 st033144 30.6155 µM 0.417049957276087 0.345510590191014 no 1166 0.338320933595343 399 674617
SGTC_1743 st037606 46.3785 µM 0.416114319754972 0.345827076929587 no 1167 0.338663175987594 329 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_193 1273-0060 1.558 µM 0.415815080031835 0.345928319869226 no 1168 0.33877266160029 361 2847393 YHR072W ERG7
SGTC_18 0111-0177 500 nM 0.415189274089259 0.346140086831026 no 1169 0.339001675053823 368 721752
SGTC_640 3381-0960 37.1 µM 0.415038048579016 0.346191267371281 no 1170 0.339057024904322 364 1745025
SGTC_1173 0443-0020 122 µM 0.414406287389569 0.346405110075969 no 1171 0.339288292548506 380 5331295
SGTC_586 0957-0265 8.15 µM 0.413193659511051 0.346815705526919 no 1172 0.339732366582194 399 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2136 5328288 199.296 µM 0.413040037365053 0.346867734795056 no 1173 0.339788640136167 357 262395
SGTC_741 4582-0002 126 µM 0.4125247420193 0.34704227784928 no 1174 0.339977424801787 375 2912688
SGTC_2250 alverine citrate 130 µM 0.410911726857122 0.347588854944463 no 1175 0.340568631620084 351 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2122 5258151 111.688 µM 0.40649086380639 0.349088505433625 no 1176 0.342190984274344 362 2173356
SGTC_2851 9015922 71.43 µM 0.406207988777407 0.349184543215072 no 1177 0.342294892362671 402 2996893
SGTC_391 gliotoxin 8.33 µM 0.40439928654323 0.349798836639414 no 1178 0.342959562379981 372 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_613 3914-0030 117 µM 0.403632647376335 0.350059330755844 no 1179 0.343241437247107 382 1145395
SGTC_2719 novobiocin 32.65 µM 0.403528614155048 0.350094685345601 no 1180 0.343279694497201 381 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1991 st073000 8.92 µM 0.40213521779997 0.350568341497247 no 1181 0.343792257732579 389 4301969 YIL048W NEO1
SGTC_165 k038-0023 64.381 µM 0.399821686311567 0.35135529150597 no 1182 0.344643928338327 369 46368543
SGTC_930 2810-3379 265 µM 0.399784026028287 0.351368106971752 no 1183 0.344657798589595 390 1015764
SGTC_719 2810-4230 27.3 µM 0.398584112608912 0.351776515429502 no 1184 0.345099834948393 379 721079
SGTC_3323 9138564 53.9225 µM 0.397202095206451 0.352247117713057 no 1185 0.345609218633935 360 43912313 YNL103W MET4
SGTC_1211 1056-0033 32.3 µM 0.397094986711008 0.352283599580349 no 1186 0.34564870834985 362 6741922
SGTC_899 1083-0020 478 µM 0.396729253062912 0.352408181141098 no 1187 0.345783562952101 401 767123
SGTC_1274 0865-0114 173 µM 0.396723791124331 0.352410041786796 no 1188 0.345785577045723 353 870624
SGTC_2749 bexarotene 57.39 µM 0.396638417290829 0.352439125409917 no 1189 0.345817059272959 361 82146 An retinoic acid receptor inhibitor.
SGTC_492 tmb-8 126 µM 0.392829384895273 0.353737593792539 no 1190 0.347222749887457 392 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_783 0848-0141 92.7 µM 0.392171923275114 0.353961889953624 no 1191 0.347465593935521 403 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1248 0469-0687 58.6 µM 0.391546876871696 0.354175174514111 no 1192 0.347696522969417 375 4017482
SGTC_47 0149-0135 24.25 µM 0.391430771701628 0.354214798117719 no 1193 0.347739425299357 352 5239155
SGTC_1016 4226-1401 38 µM 0.387751895034358 0.355471116083854 no 1194 0.349099823888514 358 2901613
SGTC_769 0302-0231 76 µM 0.386029800984247 0.356059743613607 no 1195 0.349737299103532 387 571869 YER009W NTF2
SGTC_2846 9008642 19.48 µM 0.385598144946048 0.356207341458318 no 1196 0.349897153649258 410 2992898
SGTC_2064 5220758 200 µM 0.384613138929523 0.356544229087404 no 1197 0.3502620290779 356 788518
SGTC_2842 9000675 19.48 µM 0.38372452972571 0.356848243552232 no 1198 0.350591314902116 368 2989072
SGTC_1433 4060-0023 7.6 µM 0.38370800773575 0.356853896981959 no 1199 0.350597438406827 363 3840627
SGTC_3320 9137005 35.139 µM 0.383290618418817 0.356996728047801 no 1200 0.350752147262334 389 4908713
SGTC_15 0266-0086 27.098 µM 0.381606121072314 0.357573368340685 no 1201 0.35137677164148 398 1712902 YIL048W NEO1
SGTC_2108 5365811 200 µM 0.380565323587061 0.357929818762086 no 1202 0.351762908080263 344 780283
SGTC_1604 st002052 72.4 µM 0.380063501749337 0.358101726080324 no 1203 0.351949138939605 340 6254834 YHR062C RPP1
SGTC_472 calcifediol 10 µM 0.378623190227627 0.358595288165248 no 1204 0.35248384940243 379 5283731 A vitamin D metabolite.
SGTC_1915 st067105 30.6 µM 0.378422230421706 0.358664171332924 no 1205 0.352558478215122 390 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1613 st002381 52.1 µM 0.376436332921028 0.3593451260433 no 1206 0.353296269613694 367 551167
SGTC_484 loperamide 105 µM 0.375796887644123 0.35956448399618 no 1207 0.353533950900596 369 3955 An opioid-receptor agonist.
SGTC_1611 st001856 99.4 µM 0.375594483953705 0.359633927042025 no 1208 0.353609196092882 415 647478
SGTC_2144 5628481 200 µM 0.375321265960775 0.359727673244979 no 1209 0.353710776141261 367 2818399
SGTC_2400 5203494 178.7 µM 0.373697924331764 0.360284846002809 no 1210 0.35431453488765 372 6777674
SGTC_1655 st012546 55.1 µM 0.373502991608286 0.360351771933634 no 1211 0.354387059595778 402 720985 YLR208W SEC13
SGTC_1692 fluoroquinolonic acid 71 µM 0.372561098675896 0.360675210740465 no 1212 0.354737565162948 388 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2940 9060638 45.86 µM 0.371553052849106 0.361021476383149 no 1213 0.355112824407973 370 4027022
SGTC_2437 5741531 144.16 µM 0.371499648623171 0.361039824015619 no 1214 0.355132708806532 401 2262990
SGTC_2121 5257820 149.641 µM 0.36934123222259 0.361781639831297 no 1215 0.355936697922624 377 791256
SGTC_2133 5320837 200 µM 0.369099886484927 0.361864619148038 no 1216 0.356026636778072 389 2841355
SGTC_346 4513-0042 7.16 µM 0.368903844559133 0.361932026921572 no 1217 0.356099698809104 372 2827372
SGTC_904 1141-0088 396 µM 0.366554440229208 0.362740187420682 no 1218 0.356975698734004 382 1378119
SGTC_1712 st032288 53.4 µM 0.365346243397285 0.363156027794926 no 1219 0.357426481654043 381 2883011
SGTC_2974 9094440 9.66 µM 0.364407920954703 0.363479093442414 no 1220 0.357776710728135 365 25236134
SGTC_691 1548-0686 185 µM 0.363313942394476 0.363855874306678 no 1221 0.358185189693224 396 46495133
SGTC_192 3455-0609 60.9 µM 0.362655689922913 0.364082648748908 no 1222 0.358431051843922 365 3769639
SGTC_1377 2944-0135 198 µM 0.362408884433445 0.364167687938547 no 1223 0.358523250648904 360 1894137
SGTC_2734 clemastine 41.6 µM 0.361284590673363 0.364555158668885 no 1224 0.35894335588372 426 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1833 st055984 71 µM 0.36072025971419 0.364749698946732 no 1225 0.359154288972035 378 676288
SGTC_2836 9010338 19.48 µM 0.358970258640759 0.365353193334881 no 1226 0.359808669304637 367 2994051
SGTC_1003 4049-0218 100 µM 0.358543971069783 0.365500250768863 no 1227 0.35996813395889 381 295161
SGTC_1963 st076565 50.3 µM 0.357369216192836 0.365905611013553 no 1228 0.36040770957149 403 4914280
SGTC_2832 7992762 51.95 µM 0.355800335283337 0.366447201630993 no 1229 0.360995048987273 339 2985177
SGTC_476 mead acid 10 µM 0.355760034782849 0.366461117205582 no 1230 0.36101014054633 404 5312531 An omega 9 fatty acid.
SGTC_1558 st069300 45.6 µM 0.355493672979044 0.366553095106513 no 1231 0.361109892015471 393 24208000
SGTC_3263 9137018 49.47 µM 0.353562166296147 0.367220296355655 no 1232 0.361833516036869 420 43844957
SGTC_872 0588-0139 234 µM 0.350687096726616 0.368214175432563 no 1233 0.362911553429663 370 2047100
SGTC_2587 piperic acid 92.2 µM 0.348972593890559 0.368807280260567 no 1234 0.363554942305519 391 5370536
SGTC_2272 7805186 180 µM 0.348180192636435 0.369081504508046 no 1235 0.363852431109427 436 2956062 YPR165W RHO1
SGTC_265 mycophenolic acid 32.932 µM 0.348011650846862 0.369139839928149 no 1236 0.363915716835597 392 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2713 st079149 53.4 µM 0.347282855490955 0.369392124112954 no 1237 0.364189414782486 387 3103253
SGTC_2006 4011487 200 µM 0.345451900034265 0.370026186642479 no 1238 0.36487733260085 376 45595294
SGTC_163 TUB2.036 7.546 µM 0.343973039220236 0.370538576409578 no 1239 0.365433280950298 389 15992207 YJR013W GPI14
SGTC_2049 5262831 67.185 µM 0.343532343024682 0.370691311534059 no 1240 0.365599006688485 390 763417
SGTC_2486 5283202 22.39 µM 0.342303742376321 0.371117223687841 no 1241 0.366061159748869 389 1377751
SGTC_849 0386-0493 241 µM 0.341639126620513 0.371347688186407 no 1242 0.366311244104227 400 726119
SGTC_2067 5224629 34.075 µM 0.338715579941376 0.372362014328905 no 1243 0.367412001331504 383 2835000
SGTC_2192 5915882 198.485 µM 0.338645115263553 0.37238647305149 no 1244 0.367438545785536 383 2876149
SGTC_1197 1601-0112 267 µM 0.338525728727783 0.372427914026319 no 1245 0.367483520833718 388 7350313
SGTC_1478 0453-0656 35.7 µM 0.336293608644901 0.373202990085535 no 1246 0.368324734561683 409 5258496
SGTC_2276 7947513 42.08 µM 0.334923836402267 0.373678880938008 no 1247 0.368841270335864 397 2105100
SGTC_2318 6029776 164 µM 0.334418851363389 0.373854373175428 no 1248 0.369031758070238 409 818325
SGTC_2397 5161689 200 µM 0.334204942040259 0.373928718761985 no 1249 0.369112457494786 385 2259942
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.333313754742996 0.374238507191779 no 1250 0.369448728837488 397 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2267 7931562 200 µM 0.332684551064162 0.374457275597759 no 1251 0.369686206187896 378 934880
SGTC_2368 9071271 200 µM 0.330530171459009 0.375206639581932 no 1252 0.370499699453642 410 27209959
SGTC_42 0133-0086 60.653 µM 0.328901086547903 0.375773601882734 no 1253 0.371115226509483 443 162923 Model of phenazepam hydroxylation.
SGTC_2695 st077686 51.995 µM 0.327572680138835 0.376236119212749 no 1254 0.371617390624967 366 2876092
SGTC_2154 5570129 200 µM 0.323626448774843 0.377611142871134 no 1255 0.373110430740019 427 673366
SGTC_1454 4239-0054 42.6 µM 0.323146089084201 0.377778625596728 no 1256 0.373292303495618 432 1340767
SGTC_2679 rapamycin 1 nM 0.322368115568323 0.378049923411491 no 1257 0.373586918034173 394 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_356 1634-0012 32.5 µM 0.322092869007143 0.378145922826567 no 1258 0.373691170185946 432 735457
SGTC_2665 lovastatin 100 µM 0.322074823998369 0.378152216756743 no 1259 0.373698005220933 400 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_744 1594-0068 283 µM 0.321322385816253 0.378414688919184 no 1260 0.373983046866014 391 668392
SGTC_625 k213-0058 121 µM 0.321090689164492 0.378495522705138 no 1261 0.374070833005672 397 3655420
SGTC_1019 4262-0212 3.4 µM 0.32104594840877 0.378511132367938 no 1262 0.374087785311835 401 4677213
SGTC_1862 st057513 3.81 µM 0.320370649924659 0.378746762232794 no 1263 0.374343685975082 400 5393163
SGTC_898 1000-0849 28.3 µM 0.317511089329314 0.379745038720392 no 1264 0.375427913198358 426 6751807
SGTC_1350 1495-0454 146 µM 0.316620544292937 0.380056093288575 no 1265 0.375765772569328 426 1069057
SGTC_2729 fluphenazine 10.66 µM 0.316585341009135 0.380068390884847 no 1266 0.375779130124072 411 3372 An atypical antipsychotic.
SGTC_2033 5192550 145 µM 0.31628969192866 0.380171675040717 no 1267 0.375891317259015 385 182073
SGTC_1731 st035964 63 µM 0.316081160628601 0.380244529990407 no 1268 0.375970452951342 411 6739575
SGTC_2661 dactinomycin 12.96 µM 0.315878351379126 0.380315389892839 no 1269 0.376047422182118 405 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1469 k284-2957 126 µM 0.315541116939288 0.380433225755114 no 1270 0.376175418756391 393 23884841
SGTC_1001 4048-4355 44.4 µM 0.310024702993999 0.382362329183948 no 1271 0.378271085484587 422 21824233
SGTC_2640 pentamidine 10.38 µM 0.306566069804925 0.383573315893303 no 1272 0.37958684157234 410 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2987 9018338 71.43 µM 0.305752528815317 0.383858330421796 no 1273 0.379896537517982 421 5055682
SGTC_3177 9107506 49.47 µM 0.305235995583948 0.384039324394543 no 1274 0.380093209585659 432 8897194
SGTC_34 0469-0683 81.75 µM 0.304686620177418 0.384231854068601 no 1275 0.380302420471031 403 3690923
SGTC_1646 st011709 75.6 µM 0.304610476712269 0.384258540948464 no 1276 0.38033141987734 404 5757843
SGTC_230 MPP+ 141.667 µM 0.301167377148154 0.385465855345623 no 1277 0.381643432444238 411 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2132 5317594 122.667 µM 0.301057083042985 0.385504548123746 no 1278 0.381685483212648 431 794577
SGTC_1581 himbacine 57.9 µM 0.295045947647532 0.387615055644535 no 1279 0.383979390013406 418 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1463 k081-0032 34.1 µM 0.294711004261881 0.387732752521698 no 1280 0.384107328084111 402 977755
SGTC_1389 3405-0187 19 µM 0.292587234176528 0.388479270862144 no 1281 0.384918836309467 424 799890
SGTC_541 4513-1321 94 µM 0.29247275211231 0.388519523747649 no 1282 0.384962595109413 397 747515
SGTC_296 1222-0039 74.9 µM 0.291233316851364 0.388955396481534 no 1283 0.385436441610324 399 5984176
SGTC_376 3970-0862 59.1 µM 0.290387524777773 0.389252916832934 no 1284 0.385759893259953 423 3135186
SGTC_3055 9094636 49.47 µM 0.289750504490914 0.389477041385374 no 1285 0.386003557920318 424 25236176
SGTC_2424 5537928 59.2 µM 0.289077868770546 0.389713736517972 no 1286 0.38626089454966 438 5382802
SGTC_2963 9082507 9 µM 0.288009879282849 0.390089637493273 no 1287 0.386669588184423 420 16459611
SGTC_3131 9127911 49.47 µM 0.287493847409118 0.390271302434657 no 1288 0.386867106125984 400 45595681
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.28664646793069 0.390569667646873 no 1289 0.387191515241812 401 803109
SGTC_2258 7960471 200 µM 0.286451474514695 0.390638334623434 no 1290 0.387266177304642 448 2974708
SGTC_357 1325-0123 420 µM 0.286080222191996 0.390769080641933 no 1291 0.387408339601431 434 1098503
SGTC_1253 0550-0034 176 µM 0.284894068499934 0.391186897753043 no 1292 0.387862650207121 396 5969915
SGTC_2243 6634756 200 µM 0.282309810192115 0.392097625029388 no 1293 0.388852981974093 372 885676
SGTC_1710 st031758 61.5 µM 0.282237106034332 0.392123255526165 no 1294 0.388880853926354 429 5394341
SGTC_1394 3474-0001 65.7 µM 0.281426579620705 0.392409023189378 no 1295 0.389191616992838 413 5017666 YIL048W NEO1
SGTC_1569 carminic acid 40.6 µM 0.281343291197327 0.392438391516586 no 1296 0.389223554538255 441 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1000 4048-0884 8.67 µM 0.280340031884526 0.392792198821481 no 1297 0.389608320285531 423 13040088
SGTC_61 0978-8327 98.565 µM 0.27859980356987 0.393406114030222 no 1298 0.390275981734358 425 6150059 YHR072W ERG7
SGTC_1815 st051655 58.2 µM 0.27789199018375 0.393655891338506 no 1299 0.390547636370105 415 5984156
SGTC_2475 5812728 15.03 µM 0.276626697085672 0.394102504312587 no 1300 0.391033381521154 407 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2830 7992007 71.43 µM 0.274739331060236 0.394768950265449 no 1301 0.391758255825299 398 1952075
SGTC_2069 5228469 200 µM 0.27465051714863 0.394800318862219 no 1302 0.391792375565755 430 2835210
SGTC_871 0574-0004 149 µM 0.274644098234983 0.394802586014488 no 1303 0.391794841559294 412 9551173
SGTC_2233 sulbentine 40.3845 µM 0.273954892849513 0.395046033204714 no 1304 0.392059643104807 418 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2403 6032726 181.2 µM 0.273818756103678 0.39509412547331 no 1305 0.392111954505533 399 2881040
SGTC_101 0490-5701 117.494 µM 0.273510404622124 0.395203060988979 no 1306 0.39223044771064 442 4661669
SGTC_2517 totarol 10 µM 0.273109981094677 0.395344536270144 no 1307 0.392384337244962 391 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_432 NS 1619 61.3 µM 0.272662455258679 0.39550266978495 no 1308 0.392556348908393 387 4552 A K+/calcium channel activator.
SGTC_271 rotenone 740 µM 0.272015493695384 0.395731304440376 no 1309 0.392805053068305 437 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1285 0929-0069 65.5 µM 0.271665855875416 0.395854880543864 no 1310 0.39293947863044 403 1206237
SGTC_1123 mangostin 811.285 nM 0.271277490521616 0.395992156791151 no 1311 0.393088808769959 416 5281650 An antioxidant.
SGTC_2701 st077767 14.721 µM 0.270162929135668 0.396386194522847 no 1312 0.393517455425803 409 5721188
SGTC_2961 9083290 32.55 µM 0.270004243106124 0.396442304387544 no 1313 0.393578494638402 435 17741490
SGTC_3082 9117008 49.47 µM 0.269439310297367 0.39664207663612 no 1314 0.393795819509877 401 41448529
SGTC_1477 0139-0234 16 µM 0.26834848882499 0.397027891028012 no 1315 0.394215542854916 407 620880
SGTC_2936 9038235 15.59 µM 0.268291051134098 0.39704820905364 no 1316 0.394237646984294 428 4749415
SGTC_1979 st071809 45.3 µM 0.265666123043109 0.397977049241065 no 1317 0.395248177967792 450 4976333
SGTC_1411 3909-8223 150 µM 0.263703884654946 0.398671772505327 no 1318 0.396004050971342 434 X1411
SGTC_2648 atorvastatin 78.68 µM 0.263566539367717 0.398720411150839 no 1319 0.396056972371843 445 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_577 r071-0003 38.6 µM 0.263076279489802 0.398894041700337 no 1320 0.39624589319246 426 4568517 YMR134W ERG29
SGTC_2869 9037858 32.47 µM 0.261589125863137 0.399420854639132 no 1321 0.396819114238381 406 27187042
SGTC_162 k030-0015 37.8 µM 0.260340025114411 0.399863480744238 no 1322 0.397300750565766 434 1809920 YMR134W ERG29
SGTC_1385 3091-4834 14.1 µM 0.256546676731917 0.401208462419938 no 1323 0.398764371608952 423 4072814
SGTC_2792 7535235 81.82 µM 0.254350788581315 0.401987579950385 no 1324 0.399612282983832 399 1281891
SGTC_1444 4112-3581 28 µM 0.252651048283978 0.402590928221841 no 1325 0.400268939285338 421 2877249
SGTC_615 k087-0205 167 µM 0.252191524676937 0.40275408292116 no 1326 0.400446514368215 451 9642773
SGTC_1375 2910-0797 186 µM 0.250642085171817 0.403304338933648 no 1327 0.401045420395475 457 742508
SGTC_2292 7671323 168.05 µM 0.249488792884708 0.403714034658748 no 1328 0.401491354432699 448 937504
SGTC_2330 7979373 200 µM 0.2485728648027 0.404039484396385 no 1329 0.401845600262167 402 1863007
SGTC_1148 3909-7663 27.7 µM 0.247628731692542 0.404375025544096 no 1330 0.402210839137183 433 4084526
SGTC_3062 9077494 49.47 µM 0.247276123434631 0.404500359171336 no 1331 0.40234726792803 405 16459633
SGTC_3275 9138069 49.47 µM 0.245773805487584 0.405034463598926 no 1332 0.402928667697604 452 17617007
SGTC_950 1165-0508 94.1 µM 0.245619746434302 0.405089244729004 no 1333 0.40298830098937 428 6148369
SGTC_2816 7982706 58.44 µM 0.242782644839566 0.406098407678862 no 1334 0.404086890402565 420 2981853
SGTC_1902 st060212 70.5 µM 0.241864936647794 0.406424972331126 no 1335 0.404442410041263 414 688944
SGTC_1931 st074438 57.1 µM 0.241280368604848 0.406633023672396 no 1336 0.404668912537664 463 2787313
SGTC_1261 0712-0010 12.7 µM 0.24021364312904 0.407012745686313 no 1337 0.405082318799331 454 2840123
SGTC_1297 1068-0111 14.1 µM 0.239463357079859 0.407279877224135 no 1338 0.405373153400392 445 767057
SGTC_1293 1000-1278 195 µM 0.239389176960315 0.40730629062844 no 1339 0.405401910802004 448 678847
SGTC_2184 6075246 200 µM 0.238790373655338 0.407519522664633 no 1340 0.405634067522793 452 2267320
SGTC_3318 9139014 38.6185 µM 0.238761356153537 0.407529856405459 no 1341 0.405645318485154 470 16643984
SGTC_5 0352-0601 109.883 µM 0.23838868629916 0.407662577672139 no 1342 0.405789820775816 426 762456
SGTC_2688 kanamycin b 96.69 µM 0.238093732059175 0.407767629101254 no 1343 0.405904198032288 446 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2065 5221596 34.26 µM 0.236771270321859 0.408238720860014 no 1344 0.40641712041499 407 788581
SGTC_1908 st060353 56.5 µM 0.236437666254995 0.408357579400183 no 1345 0.406546535569186 435 4227716
SGTC_653 0203-0016 55.2 µM 0.234829569719435 0.408930640166865 no 1346 0.407170508037781 447 295302
SGTC_1635 st007035 42.4 µM 0.232219202996962 0.409861283708579 no 1347 0.408183881773782 418 3716403
SGTC_2778 tioconazole 65.09 nM 0.231362074226182 0.410166976862003 no 1348 0.408516763134601 445 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1232 0279-0259 161 µM 0.230085329485187 0.410622426341116 no 1349 0.409012732239193 444 1560000
SGTC_1382 3002-2117 298 µM 0.22722772385495 0.411642247751889 no 1350 0.410123335474247 463 1497314
SGTC_754 3474-0146 171 µM 0.226179681026547 0.412016422993762 no 1351 0.410530836671155 407 24762078
SGTC_1393 3470-5649 58.2 µM 0.22556833058862 0.412234726040147 no 1352 0.410768587279857 468 4108395
SGTC_594 1487-1584 10.8 µM 0.224749263584743 0.412527243764384 no 1353 0.411087169022419 434 5013332
SGTC_3059 1327-0034 3 µM 0.224667828870038 0.412556329632414 no 1354 0.411118846823488 417 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2467 5474540 200 µM 0.223369231621508 0.413020211693784 no 1355 0.411624074499056 407 5413519
SGTC_686 1319-0111 510 µM 0.22311922477457 0.413109532555641 no 1356 0.411721358133372 463 4562600
SGTC_944 3370-0224 231 µM 0.222812210581395 0.413219226793898 no 1357 0.411840832110828 418 4580514
SGTC_341 1486-1430 230 µM 0.222135458233124 0.413461050062017 no 1358 0.412104217822889 445 2054753 YPL210C SRP72
SGTC_1354 1498-1681 81 µM 0.221809760471721 0.41357744303862 no 1359 0.41223099048015 435 5754243
SGTC_1357 1503-1303 39.5 µM 0.221324070106457 0.413751025873394 no 1360 0.412420054714353 420 292895
SGTC_1505 k297-0037 20.6 µM 0.22040025093288 0.414081239818623 no 1361 0.412779725000113 415 4089396
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.220117536746892 0.41418230655882 no 1362 0.412889808692598 462 1241132 A phosphatase inhibitor.
SGTC_2316 5844804 197.44 µM 0.219811682637198 0.414291651928439 no 1363 0.413008910359357 440 776813
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.219419966885691 0.414431703245543 no 1364 0.413161458825834 454 5282309
SGTC_2931 9014674 55.67 µM 0.219176026392202 0.414518925526244 no 1365 0.413256464818963 429 2996810
SGTC_731 3966-0296 387 µM 0.218654683839854 0.414705348581904 no 1366 0.413459525895915 433 660956
SGTC_1007 4101-0031 70 µM 0.218279064241271 0.41483967554629 no 1367 0.413605842749331 453 1146276
SGTC_1082 camptothecin 424.86 nM 0.218034606222072 0.414927102595824 no 1368 0.413701074067076 497 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_978 1416-0512 87.4 µM 0.217840031359503 0.41499669263197 no 1369 0.4137768764792 438 6814003
SGTC_819 1013-0258 27.7 µM 0.217663728928535 0.415059749804697 no 1370 0.413845563098005 429 5753198
SGTC_516 3992-2719 87.3 µM 0.21559543373268 0.415799669177832 no 1371 0.414651557727409 416 5350887 YDR037W KRS1
SGTC_590 k048-0076 22.4 µM 0.215324713153885 0.415896539888759 no 1372 0.414757081594604 448 6832814
SGTC_2925 9010536 32.5 µM 0.214343480002295 0.416247692863055 no 1373 0.415139606851657 433 2994177
SGTC_2612 dictamnine 15.46 µM 0.21325871453647 0.416635974655972 no 1374 0.415562586915477 466 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2472 5377652 49.4 µM 0.21301579325814 0.416722937248627 no 1375 0.415657322070202 452 1610903
SGTC_253 dyclonine 31.25 µM 0.211983421898262 0.417092557904068 no 1376 0.416059983912593 424 3180 An oral anasthetic.
SGTC_2911 7942208 15.64 µM 0.211948331975359 0.417105122463928 no 1377 0.416073671791538 431 1243384
SGTC_2370 9071495 200 µM 0.211828694037853 0.417147961553648 no 1378 0.416120340929539 453 21791103
SGTC_861 0443-0273 110 µM 0.211368765743945 0.417312658514593 no 1379 0.416299763731298 453 6149169
SGTC_2084 5306078 60.6385 µM 0.211354616362759 0.417317725534784 no 1380 0.416305283828534 461 679340
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.211126942497496 0.417399259473533 no 1381 0.416394108489116 406 6708561
SGTC_735 3076-0345 636 µM 0.209784942363411 0.417879924928244 no 1382 0.416917762907931 465 2888990
SGTC_3217 9129673 49.47 µM 0.209200840978267 0.418089171439716 no 1383 0.417145727972088 407 17248312
SGTC_1105 epirubicin 18.1 µM 0.208815769858895 0.418227130705338 no 1384 0.417296030071964 438 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_966 1300-0360 30.2 µM 0.207434697551886 0.418722009527235 no 1385 0.417835193561377 460 70588
SGTC_217 ketoconazole 989 nM 0.207370809168497 0.418744905733235 no 1386 0.417860139002047 446 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3103 9120822 49.47 µM 0.207213415012005 0.418801313547238 no 1387 0.417921595505646 481 17141819
SGTC_413 propylparaben 100 µM 0.205964533950228 0.419248953738723 no 1388 0.418409307561011 436 7175 A pharmaceutical preservative.
SGTC_1057 3448-5381 134 µM 0.205748341461927 0.419326454893017 no 1389 0.418493747642569 453 5497911
SGTC_1667 st014849 34.6 µM 0.205212085837127 0.419518706482375 no 1390 0.418703213625921 472 5348460
SGTC_1871 st057448 67.3 µM 0.20426271877283 0.419859108651591 no 1391 0.419074100926082 475 691747
SGTC_2838 9002687 71.43 µM 0.204157260171134 0.419896925272627 no 1392 0.419115304668242 460 6457060
SGTC_295 k015-0027 31 µM 0.202691156069374 0.420422735082133 no 1393 0.419688218066225 440 3887424
SGTC_792 4534-1957 155 µM 0.201783233708601 0.420748427493906 no 1394 0.420043094750733 435 1717904
SGTC_1504 k297-0033 30 µM 0.201387587252324 0.420890371867057 no 1395 0.420197760162041 423 4388117
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.201028888757255 0.421019069469132 no 1396 0.420337992593847 473 140250 A respiratory chain inhibitor.
SGTC_3237 9133362 49.47 µM 0.200863788592373 0.421078308672416 no 1397 0.420402541559926 480 43845137
SGTC_963 1269-2853 151 µM 0.19975708352917 0.421475448991459 no 1398 0.420835283578645 415 3668223
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.197875890403708 0.422150696911784 no 1399 0.421571083932184 447 688801
SGTC_2687 chenodiol 100 µM 0.197281525596167 0.422364089832261 no 1400 0.421803617842376 437 5702181 A cholesterol synthesis inhibitor.
SGTC_2283 7944793 200 µM 0.196686923188402 0.422577590861412 no 1401 0.422036271993345 485 2970533
SGTC_2642 cholecalciferol 100 µM 0.196447308027759 0.42266363475952 no 1402 0.422130035552752 447 9821465 A vitamin D precursor, similar to steriods.
SGTC_53 0973-0023 39.979 µM 0.195747496942105 0.422914952464987 no 1403 0.422403903151273 463 674768
SGTC_3244 9134489 49.47 µM 0.194554649958279 0.423343402578589 no 1404 0.422870804313508 469 16584271
SGTC_2805 7950783 58.44 µM 0.194140138265162 0.423492309299229 no 1405 0.423033076840868 438 1178958 YDL195W SEC31
SGTC_2186 6124449 200 µM 0.193049026829763 0.423884325881756 no 1406 0.423460286163084 472 3834182 YLR033W RSC58
SGTC_3218 9131285 49.47 µM 0.191232176528465 0.424537254278377 no 1407 0.424171847773512 470 17156417
SGTC_180 1486-1293 102.781 µM 0.189042469307553 0.425324452787911 no 1408 0.425029765579981 447 4140536
SGTC_3003 9075612 71.4286 µM 0.188553854215021 0.425500150388334 no 1409 0.425221251471418 468 6501993
SGTC_2054 5233173 129 µM 0.18829648338701 0.425592702471538 no 1410 0.425322120950768 439 6889
SGTC_126 0417-1624 672.48 µM 0.187561722677731 0.425856949343399 no 1411 0.425610117256234 479 41912 YDL195W SEC31
SGTC_1467 k284-1082 293 µM 0.185695995351933 0.42652808261019 no 1412 0.426341584474002 449 3334705
SGTC_2217 6934799 96.0675 µM 0.185641305199437 0.426547758790769 no 1413 0.426363029842658 464 675606
SGTC_1707 st032323 6.317 µM 0.185345653670435 0.426654130151101 no 1414 0.426478965926946 451 3132057 YMR211W DML1
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.18456376990572 0.426935466883116 no 1415 0.426785602550687 435 5282362
SGTC_490 phenamil 164 µM 0.184174630223806 0.427075500645487 no 1416 0.426938230585809 466 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2371 9071574 200 µM 0.183951267300823 0.427155883006555 no 1417 0.427025842744499 477 45596039
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.182961469946032 0.427512121039673 no 1418 0.427414125388289 482 688798
SGTC_1223 0764-0573 147 µM 0.182238849617413 0.427772236717087 no 1419 0.427697642927372 447 1609797
SGTC_1356 1502-0781 85.8 µM 0.180176206856946 0.428514881539818 no 1420 0.428507118457441 438 567702
SGTC_2722 naftopidil 47.16 µM 0.179717968455029 0.428679902588024 no 1421 0.428686993168352 470 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1631 benzylvanillin 81.9 µM 0.178830343812883 0.428999589874719 no 1422 0.42903545920751 428 75506
SGTC_1097 itavastatin 7.23 µM 0.178527212422164 0.429108776492283 no 1423 0.429154476018799 479 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_127 0180-0333 59.125 µM 0.178056413711767 0.42927836690623 no 1424 0.429339335894374 461 771601
SGTC_748 act1.228 77.9 µM 0.177500074060524 0.429478787576554 no 1425 0.429557803532341 422 4421505 YNR035C ARC35
SGTC_2287 7945887 168.79 µM 0.176947206907002 0.429677975292797 no 1426 0.429774928937165 467 1245853
SGTC_3026 9090633 49.47 µM 0.176156890627142 0.429962742572479 no 1427 0.430085343700111 446 25236842
SGTC_993 3909-8757 62.7 µM 0.174682766239603 0.430493997294423 no 1428 0.430664455052689 439 4288324 YLR208W SEC13
SGTC_79 0052-0007 94.094 µM 0.174516846257744 0.430553800533627 no 1429 0.430729646256871 479 2801472
SGTC_827 3253-0474 693 µM 0.17439485744412 0.430597770492564 no 1430 0.430777577780102 446 5402065
SGTC_3189 9110682 49.47 µM 0.174394523522741 0.430597890853219 no 1431 0.430777708985011 465 17122418
SGTC_1409 3909-8004 61.9 µM 0.174109814763519 0.430700515356222 no 1432 0.430889579973022 444 2119279
SGTC_1724 st037281 8.293 µM 0.1739932575992 0.430742530240524 no 1433 0.430935380533618 457 574124 YDL195W SEC31
SGTC_316 k060-0003 58.6 µM 0.171798691773857 0.431533742221415 no 1434 0.431797897023451 460 6152314
SGTC_91 0417-1751 58.384 µM 0.171510677272819 0.431637601232281 no 1435 0.431911117793255 490 6795624
SGTC_690 glyoxal 20.3 µM 0.171495307279249 0.431643143837248 no 1436 0.431917160016117 466 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3208 9114115 49.47 µM 0.17127343379808 0.431723155588035 no 1437 0.432004384273946 472 650895
SGTC_1205 4161-2785 76 µM 0.171111348336299 0.431781608425205 no 1438 0.432068106395941 429 3498106
SGTC_2281 7943571 200 µM 0.170566825762517 0.431977990387285 no 1439 0.432282192407469 483 1244024
SGTC_369 0957-0393 4.5 µM 0.17012209004678 0.432138396711659 no 1440 0.432457060695398 453 6997992
SGTC_2268 7933382 153.85 µM 0.16969043803938 0.432294094731048 no 1441 0.432626797175134 413 935025 YOR257W CDC31
SGTC_999 SEC7.066 22.7 µM 0.169596471267084 0.43232799018856 no 1442 0.432663748934061 462 740511 YDR170C SEC7
SGTC_2448 5185112 27.17 µM 0.169376064884011 0.432407496577929 no 1443 0.432750424472652 432 5718189
SGTC_2110 5483698 200 µM 0.169202489018632 0.432470111892407 no 1444 0.432818686033141 449 2848765 YHR062C RPP1
SGTC_2457 5731572 11.68 µM 0.167451403498912 0.433101888608349 no 1445 0.433507440973813 476 2865357
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.167047824028355 0.433247520946098 no 1446 0.433666209711728 441 6857784
SGTC_2508 celastrol 40.54 µM 0.165601529439902 0.433769493121297 no 1447 0.434235271797169 452 122724 Celastrol is a natural product and antioxidant.
SGTC_1881 5652484 16 µM 0.165510588317485 0.433802317922467 no 1448 0.434271058247982 475 2255129
SGTC_3293 9120939 62.045 µM 0.164550394840066 0.434148923381077 no 1449 0.43464893900982 477 934087
SGTC_805 3852-0218 479 µM 0.16398556068221 0.434352837836295 no 1450 0.434871255418561 474 6615355
SGTC_700 3453-2283 142 µM 0.163802304079976 0.434419000250465 no 1451 0.434943388893656 456 565664
SGTC_1329 1447-1697 50.6 µM 0.1634810959491 0.434534972701299 no 1452 0.435069828080407 459 2840515
SGTC_1776 st049249 45.9 µM 0.162879534977495 0.434752181915241 no 1453 0.435306642179339 473 1822314
SGTC_1457 k015-0032 57.3 µM 0.162406357395204 0.434923048813563 no 1454 0.435492932412336 466 4302660
SGTC_1513 0337-0559 19 µM 0.161844685387145 0.435125887285374 no 1455 0.435714081521392 463 775073
SGTC_2179 6298986 200 µM 0.161792659500542 0.435144676430798 no 1456 0.435734566876366 483 738374
SGTC_97 0535-0701 19.132 µM 0.161379114236687 0.435294033479747 no 1457 0.435897407741124 454 2832013 YGL099W LSG1
SGTC_2445 5742597 35.57 µM 0.159994825180726 0.435794053853442 no 1458 0.436442575307 464 1774255
SGTC_201 4262-0159 12.803 µM 0.159321752695309 0.436037212149302 no 1459 0.436707691738212 478 1341029
SGTC_1975 st070967 30.8 µM 0.157727473600468 0.436613267496017 no 1460 0.437335775334021 502 261391
SGTC_1358 1509-0022 2.48 µM 0.157645583134322 0.436642860335461 no 1461 0.437368041252623 439 3258434
SGTC_1391 3442-0225 151 µM 0.157492195349555 0.436698291186225 no 1462 0.437428479173935 460 5227075
SGTC_685 1278-0033 54.9 µM 0.156759564154147 0.43696306453647 no 1463 0.437717170951439 494 3590572
SGTC_3045 9092950 49.47 µM 0.156355460058502 0.437109120088635 no 1464 0.437876421516087 466 44120432
SGTC_3174 9107204 49.47 µM 0.155138219091273 0.437549119839761 no 1465 0.438356176221041 448 3938802
SGTC_1371 2421-0008 32.7 µM 0.155056887548059 0.437578521755993 no 1466 0.438388234894443 474 2827552
SGTC_2040 5100729 123 µM 0.155032707599148 0.437587263041488 no 1467 0.438397766047994 486 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_431 k089-0097 107 µM 0.152849133679615 0.438376771207798 no 1468 0.439258624933848 475 5499420
SGTC_1843 st055809 45.5 µM 0.151481787856028 0.438871283372691 no 1469 0.439797838118555 453 16413835
SGTC_251 melphalan 456.522 µM 0.150459066069345 0.439241221772679 no 1470 0.440201221795089 483 460612 A DNA alkylator.
SGTC_949 1165-0505 146 µM 0.150015812488866 0.439401571734848 no 1471 0.440376069937127 464 6244267
SGTC_1298 1079-1278 263 µM 0.147258940792755 0.440399110836228 no 1472 0.441463819799074 488 2840950
SGTC_3043 9092303 49.47 µM 0.14650506961948 0.440671955720785 no 1473 0.441761344061961 455 25236084
SGTC_177 1327-0068 8.361 µM 0.146327670260537 0.440736165096852 no 1474 0.441831361620374 468 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_46 0329-0187a 2.197 µM 0.145576595570534 0.441008032461715 no 1475 0.442127822577952 477 46494817
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.144288602788356 0.441474313335149 no 1476 0.442636288894621 459 4330530
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.1442594859786 0.441484855181779 no 1477 0.442647784555268 495 676296 Flavone; oxidizing agent.
SGTC_2206 7254556 146.969 µM 0.144249172675069 0.441488589160688 no 1478 0.442651856380984 482 4398905
SGTC_727 3032-0951 202 µM 0.143390328107258 0.441799555997792 no 1479 0.442990960547657 482 3652836
SGTC_3311 9131146 2.8755 µM 0.140961814656828 0.442679055474799 no 1480 0.443950054279001 467 4900406 YPR165W RHO1
SGTC_2131 toluylene red 5.2905 µM 0.140687822311922 0.442778301124333 no 1481 0.444058282896303 456 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2353 9059630 146.67 µM 0.139523589122522 0.443200050244718 no 1482 0.444518208410082 473 4779114
SGTC_885 0865-0106 16.8 µM 0.138669772267788 0.443509390475586 no 1483 0.44485555275669 498 2793380
SGTC_2811 7967822 32.47 µM 0.138313499131427 0.443638479418825 no 1484 0.444996328643228 473 2232244
SGTC_3083 9117465 49.47 µM 0.13802175789657 0.443744190882772 no 1485 0.445111610901841 486 16420915
SGTC_2290 7904846 200 µM 0.136127371693019 0.444430712469372 no 1486 0.445860294726046 465 2962154
SGTC_2880 9042983 58.44 µM 0.136114488730883 0.444435381801008 no 1487 0.445865386889023 470 6464714
SGTC_325 2810-4341 181 µM 0.135085430243229 0.444808381077623 no 1488 0.446272164783435 467 774970
SGTC_3145 9085516 49.47 µM 0.134710932650876 0.444944136074171 no 1489 0.446420214490415 468 25236195
SGTC_3151 9099821 49.47 µM 0.133348144838941 0.445438199658799 no 1490 0.446959026737471 470 17174189
SGTC_398 bronopol 33.3 µM 0.131548728279325 0.446090687857278 no 1491 0.447670620932318 495 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1172 0370-0043 85 µM 0.131202135695294 0.446216382958191 no 1492 0.44780770326181 477 376585
SGTC_2488 5268135 45.7 µM 0.130451842267872 0.446488502511556 no 1493 0.448104476387343 478 1270356 YLR208W SEC13
SGTC_2428 5615643 7.78 µM 0.129579719202227 0.446804839410104 no 1494 0.448449474838733 505 2253075
SGTC_224 benfluorex 43.875 µM 0.126227397730435 0.448021108454604 no 1495 0.4497759622821 500 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3349 9149703 23.001 µM 0.126158092568438 0.448046258531906 no 1496 0.449803391767746 473 4910494
SGTC_1706 st031321 9.9705 µM 0.125797902573329 0.44817697086106 no 1497 0.449945951044433 469 6103185
SGTC_2718 lomofungin 53.02 µM 0.125147277038076 0.448413096000043 no 1498 0.450203477904623 492 5351222 A RNA synthesis inhibitor.
SGTC_3155 9099265 49.47 µM 0.124889752582996 0.448506561876074 no 1499 0.450305415553039 499 25236499
SGTC_1967 st070177 51.4 µM 0.124717650042683 0.448569026332514 no 1500 0.450373541894737 505 5729214
SGTC_2020 4017018 200 µM 0.124674096970738 0.448584834081562 no 1501 0.450390782496599 482 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3307 9126885 69.2785 µM 0.12339643411256 0.449048602773909 no 1502 0.450896590330456 470 24824909
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.119256401083655 0.450551835569224 no 1503 0.452536111909438 501 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2835 9006588 71.43 µM 0.118124268367646 0.450963033818244 no 1504 0.452984597345555 424 2345538
SGTC_1526 st051518 75 µM 0.117279713420841 0.451269816179895 no 1505 0.453319200212434 464 673993
SGTC_1260 0700-1617 7.75 µM 0.116942848006022 0.451392189786114 no 1506 0.453452671639321 502 2853078
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.116559830844739 0.451531334618292 no 1507 0.453604435508221 492 5024745
SGTC_1127 asiatic acid 681.4 nM 0.115415599435335 0.451947053450356 no 1508 0.454057857513301 458 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2274 7947094 46.08 µM 0.114916646677082 0.45212834804295 no 1509 0.45425559518405 511 2971028
SGTC_2730 imipramine 71.33 µM 0.11374359308968 0.452554616574171 no 1510 0.454720527228399 495 3696 A tricyclic antidepressant.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.113059355580257 0.452803282604641 no 1511 0.454991748935473 473 2724 A muscle relaxant with antifungal properties.
SGTC_2902 5787006 60.46 µM 0.112803157828248 0.452896394922738 no 1512 0.455093307370238 469 591003
SGTC_3255 9139072 49.47 µM 0.111617532471272 0.453327331358155 no 1513 0.455563334995419 490 17646060
SGTC_547 1120-0019 610 nM 0.110165849308744 0.453855045995182 no 1514 0.456138922842012 504 3676939
SGTC_2484 5809818 12.04 µM 0.109461491246164 0.454111123058913 no 1515 0.456418231860981 484 2870548
SGTC_660 4031-1742 102 µM 0.108174747082635 0.454578982130952 no 1516 0.456928538148795 487 6738706
SGTC_2611 pyromycin 23.93 µM 0.10791435821139 0.45467366698865 no 1517 0.457031813715808 488 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_150 3970-0969 77.2 µM 0.106095590423181 0.455335094615199 no 1518 0.45775325486646 474 6615640
SGTC_895 0964-0006 13.7 µM 0.105795509771159 0.455444236292687 no 1519 0.457872299740154 505 6738897
SGTC_1122 capsaicin 818.572 nM 0.105795065411271 0.455444397912345 no 1520 0.45787247602479 511 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1813 st051246 8.6015 µM 0.105593159492238 0.45551783456883 no 1521 0.457952576171364 497 5291959
SGTC_1571 st070080 73.4 µM 0.104912024218457 0.455765586384565 no 1522 0.458222808839017 493 4315245
SGTC_3067 9117431 49.47 µM 0.10461253862501 0.455874524821181 no 1523 0.458341632459131 496 17150885
SGTC_22 0964-0034 14.468 µM 0.10387698128766 0.456142099221365 no 1524 0.458633487269393 504 138402
SGTC_2777 climbazole 1.536 µM 0.103772409539534 0.456180141004519 no 1525 0.45867498111441 513 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2367 9070478 135.38 µM 0.103399483373468 0.456315809752056 no 1526 0.458822961079081 500 572802
SGTC_205 1486-1330 71.903 µM 0.102495244997198 0.456644788443653 no 1527 0.459181793458369 505 4118834
SGTC_841 0251-0215 91.2 µM 0.102046664280013 0.456808001470445 no 1528 0.459359817823049 512 3888614
SGTC_1749 st037932 54.2 µM 0.101861966900199 0.456875204468476 no 1529 0.459433119451514 493 594497
SGTC_389 tpck 16.7 µM 0.0999237974525755 0.457580490423837 no 1530 0.460202411633518 461 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2473 5854593 8.94 µM 0.0996880458216443 0.45766628790923 no 1531 0.460295995658257 505 2872951
SGTC_2617 dihydrotanshinone i 20.83 µM 0.0978640039753286 0.458330180891416 no 1532 0.461020141702348 506 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1847 st056231 15 µM 0.0955348996499969 0.459178069249371 no 1533 0.461944985553608 500 5393180
SGTC_2277 7947813 106.88 µM 0.0952900021857019 0.459267232708158 no 1534 0.462042241809298 508 1246798
SGTC_919 tnp00227 403.569 nM 0.0940593819911379 0.459715313815291 no 1535 0.46253099287908 500 1269246 A methoxyflavone. YNL221C POP1
SGTC_273 hydroxyurea 18.1 mM 0.0929969791713761 0.460102186475368 no 1536 0.462952980547881 504 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2249 haloperidol 116.36 µM 0.0919486233778156 0.460483980959768 no 1537 0.463369429594404 514 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2178 5812956 200 µM 0.0908884775133159 0.460870106249531 no 1538 0.463790602954376 517 5403383
SGTC_2205 7238770 200 µM 0.0903169078437485 0.461078298127054 no 1539 0.464017692272419 498 279867
SGTC_75 0159-0059 199.013 µM 0.0896618454452731 0.461316915000222 no 1540 0.464277968349098 520 5377270
SGTC_1919 st067113 52.3 µM 0.0885442847611271 0.461724036314274 no 1541 0.464722044192166 508 1268243
SGTC_1035 k081-0041 55.2 µM 0.088239089027713 0.461835224460264 no 1542 0.46484332495812 520 731709
SGTC_1665 st014639 11.4 µM 0.0875992208503233 0.462068349306067 no 1543 0.465097610735734 508 981133 YIL048W NEO1
SGTC_1255 0566-0045 221 µM 0.0861510068018539 0.462596028918164 no 1544 0.465673188372901 510 2788469
SGTC_2441 5730946 39.09 µM 0.0842433443425824 0.463291216125195 no 1545 0.466431478423625 502 1774275
SGTC_366 0181-0206 4.31 µM 0.0841907528261758 0.463310383036653 no 1546 0.466452385130963 482 274874
SGTC_2198 6589944 200 µM 0.0840526053435517 0.463360731117081 no 1547 0.466507303345313 489 5290268
SGTC_745 0469-0705 296 µM 0.083963619345826 0.463393162523168 no 1548 0.466542678573746 511 3486736
SGTC_1170 0310-0127 64.8 µM 0.0837071426242507 0.463486638148276 no 1549 0.466644639043315 505 774975
SGTC_489 paxilline 115 µM 0.0824659452352458 0.463939033916601 no 1550 0.467138098916611 497 105008 A toxic potassium channel blocker.
SGTC_1680 diphenhydramine 100 µM 0.0819285788737235 0.464134909500622 no 1551 0.4673517540864 513 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3353 9151644 39.2805 µM 0.0818796476957409 0.46415274585247 no 1552 0.467371209436559 516 4909158
SGTC_3106 9121286 49.47 µM 0.0817218288697559 0.464210274328921 no 1553 0.467433959744755 489 15943471
SGTC_2593 nobiletin 86.24 µM 0.0811413901339819 0.464421863601079 no 1554 0.467664754811059 493 72344 An anti-infammatory.
SGTC_2336 9001819 198.65 µM 0.0810185605401593 0.464466640375327 no 1555 0.46771359592533 527 2989602
SGTC_3250 9135583 49.47 µM 0.0799060416019498 0.464872222751292 no 1556 0.468155992346951 471 7699353
SGTC_834 0312-0008 75.7 µM 0.0786312691746343 0.465337001466272 no 1557 0.468662957663932 511 6385573 YIL048W NEO1
SGTC_3116 9124943 49.47 µM 0.0785864343263557 0.465353349000034 no 1558 0.468680789002292 515 41905195 YPL160W CDC60
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0767406798097148 0.466026392325744 no 1559 0.469414921066661 513 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2556 citropten 84.59 µM 0.0753482555506462 0.466534195901613 no 1560 0.469968814098187 504 2775 A potential DNA crosslinker.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.074881894105812 0.466704285602379 no 1561 0.470154341258242 484 16623 A steroid.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0745512546276018 0.466824878951969 no 1562 0.470285879651258 513 6708760
SGTC_1108 betulinic acid 729.144 nM 0.0741488551526823 0.466971649261888 no 1563 0.470445970716112 503 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1766 st045414 44.774 µM 0.0732995528405658 0.467281436659464 no 1564 0.470783873763044 512 253960
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0731715603688963 0.467328124296502 no 1565 0.470834798621867 509 165506
SGTC_2917 7979103 53.79 µM 0.0721445130267012 0.467702775156275 no 1566 0.471243451110713 521 2980565
SGTC_3179 9107801 49.47 µM 0.0707055032270855 0.468227751551149 no 1567 0.47181607043015 494 4818259
SGTC_1765 st044815 90.4 µM 0.070401671249611 0.468338601961737 no 1568 0.471936980543126 525 645695
SGTC_1944 st076371 56.9 µM 0.068779755826499 0.468930384783018 no 1569 0.472582466215419 527 24208455
SGTC_196 k015-0023 18.111 µM 0.0679896069874254 0.469218708680244 no 1570 0.472896953781606 519 5211998
SGTC_2789 5281112 71.43 µM 0.0679630374854362 0.469228404125346 no 1571 0.472907529018149 502 765948
SGTC_223 busulfan 5 mM 0.0678865216539309 0.469256325527562 no 1572 0.472937984080936 519 2478 A DNA alkylator.
SGTC_2957 9076800 11.52 µM 0.0664151415891679 0.469793276268605 no 1573 0.473523657786952 513 16459615
SGTC_2476 5806916 10.51 µM 0.0657295795802991 0.470043477239579 no 1574 0.473796561114701 521 2870194
SGTC_2213 7173844 200 µM 0.0654225706847255 0.470155526267241 no 1575 0.473918776882977 518 892728
SGTC_1278 0874-0585 172 µM 0.064953038609298 0.470326895942873 no 1576 0.474105695505282 511 766306
SGTC_1319 1306-0155 43.7 µM 0.0648630134488976 0.470359753927687 no 1577 0.474141534772135 524 3122360
SGTC_1887 st057648 70.8 µM 0.0648062039642543 0.470380488737005 no 1578 0.474164150893764 524 688672
SGTC_2671 danthron 100 µM 0.0640030885007988 0.470673625222061 no 1579 0.474483883792092 514 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1445 4239-0156 97.7 µM 0.0635150046990948 0.470851783182961 no 1580 0.474678205673142 524 4008346
SGTC_1124 fisetin 1.16336 µM 0.0625316426208021 0.471210742877831 no 1581 0.475069732035279 496 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2639 lactacystin 53 µM 0.0604653452850722 0.471965085637589 no 1582 0.475892507892449 498 3870 A proteasome inhibitor.
SGTC_3066 9117245 49.47 µM 0.0601733443971437 0.47207169451726 no 1583 0.476008787662099 522 17176980
SGTC_3110 9122132 49.47 µM 0.0596782680583603 0.472252450364041 no 1584 0.476205940228143 517 918317
SGTC_1827 berberine 7.24 µM 0.0595212016668256 0.472309797602124 no 1585 0.476268489462326 522 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3025 9087895 49.47 µM 0.0593113275109515 0.472386426623521 no 1586 0.476352069475285 515 17173641
SGTC_118 0083-0097 135.343 µM 0.0592835540426548 0.472396567318415 no 1587 0.476363130023483 530 5207356
SGTC_2089 5281248 129.67 µM 0.0565076664919944 0.473410193165006 no 1588 0.477468694154054 506 2737878
SGTC_1572 epiandrosterone 68.9 µM 0.0547141767169825 0.474065184721881 no 1589 0.478183087447399 509 441302 A steroid.
SGTC_2083 5306046 65.942 µM 0.0545605847873463 0.474121280557497 no 1590 0.478244270370852 528 539837
SGTC_1802 st050112 57.9 µM 0.054227811698737 0.474242819850866 no 1591 0.47837683137391 528 4662563
SGTC_2813 7971799 71.43 µM 0.0531831806338538 0.474624367792495 no 1592 0.478792978279102 523 2234054
SGTC_2937 9044753 11.33 µM 0.0530223492198524 0.474683112995486 no 1593 0.478857050327876 522 6465530 YGL099W LSG1
SGTC_512 prima-1 270 µM 0.0516971612024121 0.475167171352973 no 1594 0.479384999624593 502 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2681 menadione 3.18 µM 0.0515353150586427 0.475226292266472 no 1595 0.479449480940232 526 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3068 9116768 49.47 µM 0.0509578662512979 0.475437233461198 no 1596 0.47967954738088 532 41904888
SGTC_2385 9074692 200 µM 0.0509420213347678 0.475443021683077 no 1597 0.479685860388735 517 17046906
SGTC_1575 cyproterone acetate 48 µM 0.0490948996850239 0.476117819028245 no 1598 0.480421833984855 517 9880 An androgen receptor antagonist and liver toxin.
SGTC_2947 9072639 7.68 µM 0.0480226665344042 0.476509562773569 no 1599 0.480849089081351 511 16488146
SGTC_139 0099-0334 718.624 µM 0.0460527876505804 0.477229323100152 no 1600 0.481634088024232 528 97690
SGTC_1258 0671-0043 57.1 µM 0.0458114345805319 0.477317514573263 no 1601 0.481730272451639 519 4298767
SGTC_1998 st075797 76.8 µM 0.0453342800758709 0.477491872192399 no 1602 0.481920431983693 530 24208315
SGTC_599 1935-0052 86.5 µM 0.0449887141470572 0.477618148558906 no 1603 0.482058152326535 524 9557311
SGTC_2907 7721985 69.9 µM 0.0447773577221662 0.477695383327018 no 1604 0.482142386453485 520 3267881
SGTC_1156 4092-0367 4.88 µM 0.0412938653892637 0.478968454518484 no 1605 0.483530811805474 525 1357585
SGTC_730 1436-0052 41.2 µM 0.0390456928116456 0.479790182606812 no 1606 0.484426979386994 508 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2841 9004761 38.96 µM 0.0383416795240834 0.480047523868511 no 1607 0.484707629873774 529 2991039
SGTC_40 0327-0103 19.753 µM 0.0371860832138967 0.480469952358727 no 1608 0.485168317462464 528 409036
SGTC_412 gemfibrozil 100 µM 0.0362443744788785 0.480814210439195 no 1609 0.485543751749311 534 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2643 anethole 100 µM 0.0335966460011742 0.48178220968727 no 1610 0.486599398431688 528 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2867 9039098 71.43 µM 0.0327819684900651 0.482080074496397 no 1611 0.486924228772306 510 6463460
SGTC_334 1502-1024 68.5 µM 0.0322321786965866 0.482281095935764 no 1612 0.487143447307704 533 3296216
SGTC_2724 maprotiline 69.64 µM 0.0310881124892194 0.482699418984643 no 1613 0.487599634973997 536 4011 A tricyclic antidepressant.
SGTC_1649 st011737 51.3 µM 0.0309312504474033 0.482756776432728 no 1614 0.48766218379389 534 1761035
SGTC_1367 1812-0510 76.9 µM 0.0307726634100479 0.482814764997479 no 1615 0.487725420765143 533 1142582 YDR527W RBA50
SGTC_908 3448-7491 47.7 µM 0.0302723593243046 0.482997707394809 no 1616 0.487924920265046 537 1203031
SGTC_1700 st030840 7.9285 µM 0.0293698701791863 0.483327722776739 no 1617 0.488284801273957 525 5499307
SGTC_2952 9073731 13.78 µM 0.0287736204744278 0.483545761124272 no 1618 0.488522569989047 525 16457353
SGTC_2766 oltipraz 83.91 µM 0.0282212295095304 0.483747765471177 no 1619 0.488742852633171 533 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2468 5987765 72.9 µM 0.0273123296404258 0.484080150933359 no 1620 0.489105311453405 524 26772094
SGTC_463 ikarugamyin 104 µM 0.0264813594231424 0.484384047141729 no 1621 0.489436700705459 540 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3354 9151612 71.43 µM 0.025160318630228 0.48486718689472 no 1622 0.489963544036947 534 27261949
SGTC_1896 st058441 89 µM 0.024452886888952 0.485125922677058 no 1623 0.490245681640641 538 688759
SGTC_575 k072-0246 11.9 µM 0.0232374626317962 0.485570465986115 no 1624 0.490730427904514 535 6796779
SGTC_1737 st035557 69.7 µM 0.0220076730030179 0.486020281702278 no 1625 0.491220917424968 540 5716916
SGTC_1704 st028805 70.8 µM 0.021594614003699 0.486171368821391 no 1626 0.491385664966856 535 2876101
SGTC_1656 st012921 11 µM 0.0214978993064555 0.486206745035934 no 1627 0.491424239593703 536 6732821
SGTC_1050 3232-1156 69.3 µM 0.0204243191510609 0.486599445442002 no 1628 0.491852442008956 538 700529
SGTC_2239 6685329 187.64 µM 0.0187023247539254 0.487229353565916 no 1629 0.492539286847313 534 805680
SGTC_2303 7774051 200 µM 0.0186896365929345 0.487233995034344 no 1630 0.492544347806612 538 2953184
SGTC_1152 3909-8331 15.9 µM 0.0175150834408067 0.487663666863477 no 1631 0.493012849923356 543 16001939
SGTC_1873 rapamycin 2 nM 0.0167346829605154 0.487949158786442 no 1632 0.493324139014773 541 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3248 9135562 49.47 µM 0.0162357376967137 0.488131689908767 no 1633 0.493523162328705 531 17650701
SGTC_285 1486-1325 46 µM 0.0159719834088826 0.488228181191555 no 1634 0.493628371422404 539 22310230
SGTC_1925 st057770 10.1 µM 0.0155680572883115 0.488375953959993 no 1635 0.493789494592572 527 5989122
SGTC_347 4534-1311 26.2 µM 0.0147535394686436 0.488673942871857 no 1636 0.494114402837803 541 2862016
SGTC_1470 k295-0292 231 µM 0.0141810942857819 0.488883374025608 no 1637 0.494342751523028 542 5045612
SGTC_1325 1431-0015 227 µM 0.0137802503092692 0.489030026081528 no 1638 0.494502649504504 528 1103340
SGTC_569 4130-2812 160 µM 0.0136697557343426 0.489070451689482 no 1639 0.494546726310479 539 743552
SGTC_888 0916-0002 6.97 µM 0.0132808631187195 0.489212733053027 no 1640 0.494701857931063 534 2802138 YIL048W NEO1
SGTC_2013 4024628 200 µM 0.0129981598127388 0.489316164555056 no 1641 0.494814630496923 542 5230760
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0126288149726888 0.489451296322175 no 1642 0.494961965673187 545 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3001 9076041 71.4286 µM 0.0125922924214639 0.489464658851562 no 1643 0.494976534904568 540 16004211
SGTC_3312 9133330 71.43 µM 0.0118100320508484 0.489750867772762 no 1644 0.495288588404422 542 17617324
SGTC_1094 duloxetine 25.4 µM 0.0110994799927716 0.490010845047323 no 1645 0.495572039060259 544 60834 A selective serotonin reuptake inhibitor.
SGTC_2000 st075254 36.4 µM 0.0108249436890069 0.490111293721203 no 1646 0.495681556618427 541 17234175
SGTC_3091 9116372 49.47 µM 0.00906231125575482 0.490756228887616 no 1647 0.496384710366559 540 17169793
SGTC_2097 5376186 200 µM 0.00803931264570505 0.491130548282373 no 1648 0.496792812827344 541 742755
SGTC_1829 berberine 14.4 µM 0.00789873226502011 0.491181987839149 no 1649 0.496848894504177 542 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_520 3584-0023 682 µM 0.00704288799375841 0.491495151668815 no 1650 0.49719031743095 541 1340790
SGTC_775 4577-0580 57.3 µM 0.006950485001678 0.491528963364631 no 1651 0.497227179989025 541 2006902
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.00632070217676793 0.491759412330252 no 1652 0.49747842144992 543 688662
SGTC_668 1682-0499 62.6 µM 0.00575792910063735 0.491965343542044 no 1653 0.497702931326948 543 682214
SGTC_3102 9121669 49.47 µM 0.00558413663219772 0.492028938515106 no 1654 0.497772263375647 545 41905072
SGTC_384 k007-0144 5.16 µM 0.00300943767180883 0.492971107562674 no 1655 0.498799409884717 546 6824886
SGTC_462 ag-879 158 µM 0.00258604956147591 0.493126043423481 no 1656 0.498968316640637 547 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2231 micatex 6.853 µM 0.000937940057725836 0.493729167008191 no 1657 0.499625816109355 545 20737 An antifungal of unknown mechanism.
SGTC_1679 SEC14.276 6.7 µM 0.000878736385515759 0.493750832791989 no 1658 0.499649434947607 547 1005053 YMR079W SEC14
SGTC_3123 9126162 49.47 µM 0.000184980732314447 0.494004716372976 no 1659 0.499926203365241 547 25239884
SGTC_445 e6 berbamine 66 µM -0.000178531008220315 0.494137746409085 no 1660 0.499928776432837 549 6610268 A calcium/calmodulin antagonist.
SGTC_855 0428-0020 25 µM -0.000225491584577925 0.4941549320564 no 1661 0.4999100418738 549 6812414
SGTC_1756 st041558 35.5 µM -0.00100764359144034 0.494441169222427 no 1662 0.499598008435826 550 3955792
SGTC_1725 st036284 20.55 µM -0.00193210557443273 0.494779489975077 no 1663 0.499229201875729 551 707914
SGTC_1033 k072-0102 21.3 µM -0.0031062056557743 0.495209174921857 no 1664 0.498760805225021 550 5965931
SGTC_2610 ononetin 44.17 µM -0.00320478793525659 0.495245253299922 no 1665 0.498721476781454 549 259632
SGTC_1733 st037357 54.9 µM -0.00377735801302481 0.495454798815815 no 1666 0.498493055764014 553 1272339 YGL099W LSG1
SGTC_722 3534-0461 190 µM -0.00408600806641316 0.495567757101893 no 1667 0.498369923160062 549 658262
SGTC_2786 7743617 45.45 µM -0.00524683185120149 0.495992593004855 no 1668 0.497906826540317 551 583674
SGTC_1502 4534-4282 27.7 µM -0.00700917672929899 0.496637580889829 no 1669 0.49720376594772 554 3278949
SGTC_1024 4507-0395 26 µM -0.00739668971841583 0.496779405210062 no 1670 0.497049174643448 550 4201836
SGTC_314 1671-0008 2.74 µM -0.00798646025099062 0.496995253730278 no 1671 0.496813897205327 554 3913060
SGTC_401 neomycin 50 µM -0.00983613007777282 0.497672214795219 no 1672 0.49607601511045 556 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2137 5261020 140 µM -0.0101197203221077 0.49777600669211 no 1673 0.495962884603774 554 763655
SGTC_1933 st074711 15.9 µM -0.0103307582563611 0.497853245087172 no 1674 0.49587869705044 554 17250958
SGTC_3030 9087619 49.47 µM -0.0125780748264125 0.49867575151051 no 1675 0.494982206455192 554 25236973
SGTC_2583 asiatic acid 100 µM -0.0127458474217463 0.498737155695319 no 1676 0.494915280238696 552 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_529 4076-0302 30.3 µM -0.0143573721863387 0.499326969450502 no 1677 0.494272433974565 565 5816522
SGTC_1243 0416-0003 5.65 µM -0.0159499908095371 0.499909865058764 no 1678 0.493637144082636 562 2141977
SGTC_3041 9091929 49.47 µM -0.0164425335796861 0.499909865058764 no 1679 0.493440673719339 556 25236887
SGTC_2821 7996764 71.43 µM -0.0164692244540235 0.499900096240753 no 1680 0.493430027042702 556 2987135
SGTC_1744 st037937 38.9 µM -0.0166505186053525 0.499833742868507 no 1681 0.493357711056909 558 1016152
SGTC_882 0843-0131 351 µM -0.017077947878378 0.49967730445305 no 1682 0.493187215695681 570 5425421
SGTC_2440 5628896 157.78 µM -0.0171676710573242 0.499644465921671 no 1683 0.493151426572981 553 5522048
SGTC_3289 9119912 71.43 µM -0.0180363930948295 0.499326515286636 no 1684 0.492804910318188 562 17014829
SGTC_1140 3229-1848 2.98 µM -0.0187288575989332 0.499073074874588 no 1685 0.492528703627292 555 2849525
SGTC_728 3030-5151 22.5 µM -0.0216010174782585 0.498021876119834 no 1686 0.491383110945863 566 3125388
SGTC_1326 1431-2094 10.8 µM -0.0219295057223743 0.497901651505516 no 1687 0.49125209413401 570 616278
SGTC_2094 5332512 191.667 µM -0.0220107434308122 0.497871919048347 no 1688 0.491219692798146 561 755774
SGTC_1759 st043059 70 µM -0.0239814654299443 0.49715065201004 no 1689 0.490433696450028 560 669426
SGTC_2405 ticlatone 3.52 µM -0.0241045915260428 0.497105589218997 no 1690 0.490384590439843 582 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_782 0083-0095 30.5 µM -0.0242371454331726 0.497057075994558 no 1691 0.4903317245271 588 3591729 An indicator and reagent.
SGTC_141 0443-0274 32.331 µM -0.0249217786303619 0.496806508729313 no 1692 0.49005867789652 562 1627241
SGTC_829 1635-0120 117 µM -0.0259494097584895 0.496430410867918 no 1693 0.489648845005006 560 285054
SGTC_517 1365-0151 113 µM -0.0265539560051463 0.496209157304153 no 1694 0.489407749040486 573 768657
SGTC_211 3455-0679 143.504 µM -0.0266590722836323 0.496170686665112 no 1695 0.48936582855318 563 748649
SGTC_1789 tunicamycin 25 nM -0.0268160017829388 0.496113253399471 no 1696 0.489303245115248 562 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2389 9091542 195.52 µM -0.0271644201579853 0.495985739071626 no 1697 0.489164296913996 557 3626624 YOL127W RPL25
SGTC_1047 2043-3044 82 µM -0.0280128964404222 0.495675215047074 no 1698 0.488825932655948 566 669592
SGTC_2774 tamoxifen 10.92 µM -0.0300183219677863 0.494941283300886 no 1699 0.488026220468779 559 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2152 5568786 200 µM -0.0300356526327103 0.494934940815206 no 1700 0.488019309649962 568 5399883
SGTC_2455 5377712 9.75 µM -0.0301233773095828 0.494902836324797 no 1701 0.487984328396035 560 2243908
SGTC_2875 9039966 71.43 µM -0.0309051455251221 0.494616735069755 no 1702 0.487672593174579 583 6463691
SGTC_897 1000-0139 31.4 µM -0.0309306117920086 0.494607415305929 no 1703 0.487662438458678 579 6151020
SGTC_427 1354-0053 47.3 µM -0.0311199585072427 0.494538121117037 no 1704 0.487586936395122 587 6813657
SGTC_323 4013-0906 34.3 µM -0.0320193111262903 0.494208992210187 no 1705 0.487228325370383 557 2910086
SGTC_3272 9137413 49.47 µM -0.0323108092232198 0.494102315811046 no 1706 0.487112094596489 591 17614870
SGTC_1011 4112-3381 17.4 µM -0.0346586025637971 0.493243135360818 no 1707 0.486175985723879 596 2877139
SGTC_1324 1418-0026 34.4 µM -0.034815633085671 0.493185670749113 no 1708 0.486113377394565 602 1372513
SGTC_1907 st060210 83.7 µM -0.0348177027670037 0.493184913359499 no 1709 0.48611255221147 564 688793
SGTC_927 2425-1185 123 µM -0.0348682651439615 0.493166410316189 no 1710 0.486092392982211 578 730375
SGTC_1701 st028638 40.4 µM -0.0359016916750294 0.49278823643902 no 1711 0.485680373488485 570 3490878
SGTC_556 4058-0063 51.5 µM -0.0360115359607314 0.49274804020786 no 1712 0.485636580277474 571 6615692
SGTC_1381 2324-0066 62.1 µM -0.0381649991258877 0.491960020942429 no 1713 0.484778063602313 568 10885928
SGTC_3170 9103054 49.47 µM -0.0384170445712721 0.491867791653198 no 1714 0.484677585705304 587 16432970
SGTC_3310 9130229 44.1445 µM -0.0393264304783894 0.491535029853713 no 1715 0.484315067218611 593 7761258
SGTC_881 0833-0569 170 µM -0.0397783454371291 0.491369667652469 no 1716 0.484134920201301 561 5418700
SGTC_1221 2958-7315 257 µM -0.0402171871421183 0.49120909056256 no 1717 0.483959987678549 567 4562705
SGTC_2363 9053361 176 µM -0.0406703300708695 0.491043281990242 no 1718 0.483779357595274 565 6469797 YMR079W SEC14
SGTC_2797 7859098 81.82 µM -0.0408169939324017 0.490989616856471 no 1719 0.483720895724795 563 972681
SGTC_2128 5255449 168.493 µM -0.041870444873789 0.490604158069943 no 1720 0.483300988650985 571 736008
SGTC_2117 5521686 200 µM -0.0442983727193151 0.489715810777506 no 1721 0.482333284392432 576 803312
SGTC_631 k072-0230 41.5 µM -0.0450197707775656 0.489451870220899 no 1722 0.482045775064229 579 5773147
SGTC_1984 st072354 53.1 µM -0.045321650116431 0.489341421882926 no 1723 0.481925465434931 578 5762938
SGTC_1187 1391-0724 117 µM -0.0483427581740259 0.488236138056546 no 1724 0.480721539137514 575 6997986
SGTC_664 1222-0054 14.9 µM -0.0487475000690273 0.488088068377577 no 1725 0.480560260632899 567 6813991
SGTC_3137 9097352 49.47 µM -0.0503096238570413 0.487516600820519 no 1726 0.479937827377037 566 44120435
SGTC_48 0382-0018 55 µM -0.0505537436520751 0.487427297416313 no 1727 0.479840561439129 563 762596
SGTC_1945 st075991 56.6 µM -0.0516786080533146 0.487015810035887 no 1728 0.47939239137956 573 1084980
SGTC_2845 9003024 42.97 µM -0.0523208332772359 0.486780883378604 no 1729 0.479136526747803 577 2990173
SGTC_2328 6201408 200 µM -0.052660449690758 0.486656653189173 no 1730 0.479001225925407 579 2890418
SGTC_3009 9080819 71.4286 µM -0.0531034735621654 0.486494598954834 no 1731 0.478824731928824 578 17027216
SGTC_536 3852-0578 10.6 µM -0.0537827342054757 0.486246135728036 no 1732 0.478554132857899 576 2869208
SGTC_2782 7736369 71.43 µM -0.0549954534188872 0.485802554796221 no 1733 0.478071042979506 575 2950836 YOL077C BRX1
SGTC_467 ro 31-8220 72.8 µM -0.0553466930487543 0.485674083793659 no 1734 0.477931131737664 585 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2630 antimycin a 100 µM -0.0565525108121442 0.485233049807556 no 1735 0.477450832421456 589 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_504 lovastatin 124 µM -0.0573376119383462 0.484945904748911 no 1736 0.477138129813716 598 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1954 st077032 68.9 µM -0.0573490837263849 0.484941709082908 no 1737 0.477133560750746 619 698907
SGTC_104 0074-0074 590.992 µM -0.0582710576801172 0.484604513890194 no 1738 0.476766360477542 598 3943124
SGTC_2321 7390090 138.78 µM -0.0583912293437099 0.484560564097329 no 1739 0.476718500411827 584 649046
SGTC_1045 1348-1485 165 µM -0.0599770394053754 0.483980611336924 no 1740 0.476086960831086 576 6810614
SGTC_2460 5552655 174.22 µM -0.0607087029129951 0.483713043182745 no 1741 0.475795600272616 581 5401989
SGTC_25 0118-0223 35.662 µM -0.062880890073208 0.482918721547542 no 1742 0.474930676119024 574 5333628
SGTC_559 1550-0661 158 µM -0.0629202981809343 0.482904311475622 no 1743 0.474914985628977 588 5830875
SGTC_894 0960-0238 55.9 µM -0.0631822243733049 0.482808535426258 no 1744 0.47481069969531 566 6741907 YDL195W SEC31
SGTC_1395 3486-0190 4.35 µM -0.0640297136891547 0.482498648927849 no 1745 0.47447328362128 587 6748079
SGTC_1785 bathophenanthroline 24 µM -0.0642678487780503 0.482411576156951 no 1746 0.474378476735216 578 72812 An iron chelator.
SGTC_1825 st052143 62.6 µM -0.0653665041709203 0.482009869850987 no 1747 0.473941096410665 590 674173
SGTC_377 3970-0964 33.1 µM -0.0655120882143845 0.481956640664898 no 1748 0.473883141004631 568 16481235
SGTC_274 sirtinol 40.1 µM -0.0657554536580863 0.481867660859515 no 1749 0.473786261133836 578 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2812 7970281 58.44 µM -0.0660901155088893 0.481745302538236 no 1750 0.473653040164011 603 2233435
SGTC_315 k915-0449 187 µM -0.0663537398947823 0.481648917987054 no 1751 0.473548099603302 589 20970215 YNL149C PGA2
SGTC_2850 9015429 58.44 µM -0.0667468361337934 0.481505198813333 no 1752 0.473391623789313 579 6457570
SGTC_1520 flindersine 88 µM -0.0672499802706178 0.481321248745244 no 1753 0.47319134832383 594 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0673513386544369 0.481284192484977 no 1754 0.47315100365076 601 65057 A dermal irritant. YDR527W RBA50
SGTC_188 3229-0966 278.469 µM -0.0678831964318114 0.481089749854107 no 1755 0.472939307599494 576 5722370
SGTC_3054 9094397 49.47 µM -0.0686603844754947 0.480805624690055 no 1756 0.472629976180158 602 2598354
SGTC_1901 st060216 58.6 µM -0.069939774080059 0.480337925493582 no 1757 0.472120797742547 576 688792
SGTC_2691 st077356 60.2 µM -0.0699465220899163 0.480335458733107 no 1758 0.472118112252913 586 2839272
SGTC_495 decylubiquinone 155 µM -0.070123984382148 0.480270586992902 no 1759 0.472047488456643 611 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3124 9127567 49.47 µM -0.0704288507972409 0.480159143609783 no 1760 0.471926164320768 608 17592030
SGTC_480 am 92016 50 µM -0.0708751231743293 0.479996012324393 no 1761 0.471748571202116 624 2129 K+ channel blocker.
SGTC_368 fentichlor 4.58 µM -0.0714161957809253 0.479798232072125 no 1762 0.471533260076023 577 7329 A pesticide.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0718239732772889 0.47964917895383 no 1763 0.471370997085824 572 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3233 9132340 49.47 µM -0.0719239435167484 0.479612637704565 no 1764 0.471331217611063 609 17682950
SGTC_965 1291-5240 308 µM -0.0726403832881887 0.479350768759119 no 1765 0.471046145185068 584 2834598
SGTC_17 0960-0276 49.807 µM -0.0726755443893875 0.479337917104121 no 1766 0.471032154912538 578 6821114
SGTC_3288 9119690 36.221 µM -0.0742808414559845 0.478751191673923 no 1767 0.470393460607369 594 17595618 YKL019W RAM2
SGTC_1786 berberine 21.6 µM -0.075250074798623 0.478396965527256 no 1768 0.470007871666662 608 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0772575606653896 0.477663343353235 no 1769 0.469209325819132 596 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3281 9140613 49.47 µM -0.0774551838747486 0.477591127335637 no 1770 0.469130721103285 582 16013766
SGTC_3292 9120825 59.784 µM -0.0782078501391143 0.477316092714047 no 1771 0.46883135881921 582 24824900
SGTC_1013 4112-3890 241 µM -0.0789493595366983 0.477045145529796 no 1772 0.468536451250539 575 705171
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0798984591679962 0.476698360472144 no 1773 0.468159007659629 569 66535 A nucleotide analog.
SGTC_1118 chelidonine 707.474 nM -0.0801111504106865 0.476620649076948 no 1774 0.468074427253837 582 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1184 1269-1718 139 µM -0.0804147423139322 0.476509726679307 no 1775 0.467953701102482 575 5403821
SGTC_2026 5148700 152 µM -0.0806475906330925 0.476424652870446 no 1776 0.467861108793578 585 79838
SGTC_1145 3546-0597 10.2 µM -0.082086851545899 0.475898826355627 no 1777 0.467288824391333 583 875334
SGTC_1866 st057638 64 µM -0.0825710204074311 0.475721947159977 no 1778 0.467096322464427 591 688802
SGTC_123 0083-0120 66.675 µM -0.0828038611710705 0.475636886210248 no 1779 0.467003749451677 587 16001701
SGTC_1347 1493-0251 600 nM -0.0830996699996155 0.475528823487338 no 1780 0.466886144121199 586 3986378
SGTC_505 gw-5074 63.9 µM -0.0832125590664477 0.475487584151233 no 1781 0.466841263341966 573 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1280 0880-0253 10.1 µM -0.0838056397059222 0.475270931074099 no 1782 0.466605481980118 605 6836607
SGTC_1236 0330-0013 258 µM -0.0839827626971805 0.475206229245488 no 1783 0.466535068360556 612 4617066
SGTC_1498 4478-3555 97.6 µM -0.0841378211274094 0.475149587988202 no 1784 0.466473427164475 579 3437919
SGTC_1227 3909-8010 46.6 µM -0.0850543559130308 0.474814797509316 no 1785 0.466109088728672 583 15982272
SGTC_3160 9100216 49.47 µM -0.0861826861874866 0.474402667132367 no 1786 0.46566059695733 583 17191039
SGTC_2306 7482397 179.52 µM -0.0864331861628086 0.474311173997186 no 1787 0.465561033444911 597 891448
SGTC_2352 9027995 87.8 µM -0.0875382856016224 0.473907561403709 no 1788 0.46512182735459 597 2997347
SGTC_1722 st034304 3.6505 µM -0.0895032956518285 0.473189952307721 no 1789 0.464340967273011 594 4036148 YLR033W RSC58
SGTC_2995 9067767 71.4286 µM -0.0898593075928776 0.473059948266036 no 1790 0.464199509058991 604 11673567
SGTC_1895 st058434 18.3 µM -0.090054050607376 0.472988835631531 no 1791 0.464122131548348 631 5393175
SGTC_3341 9147222 25.867 µM -0.0904679138601014 0.472837711602629 no 1792 0.463957695201003 607 1939759
SGTC_1053 3366-3204 134 µM -0.0915454132836022 0.472444276234466 no 1793 0.463529611560015 590 3632071 YPR165W RHO1
SGTC_676 falcarinol 140 µM -0.0917565886458602 0.472367171344573 no 1794 0.463445717870103 596 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1607 st000305 50.6 µM -0.0920850751295214 0.472247235576364 no 1795 0.463315223193434 615 5457690
SGTC_3018 9082602 49.47 µM -0.0921320267326852 0.472230092986214 no 1796 0.463296571502189 593 17332089
SGTC_785 1270-0111 65.3 µM -0.0922951524110039 0.472170534256042 no 1797 0.463231769874027 587 6741994
SGTC_1801 st050089 28.441 µM -0.0928237341705924 0.471977548331113 no 1798 0.46302179763549 595 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2235 salicylic acid 500 µM -0.093719850688544 0.471650390016998 no 1799 0.462665850555933 579 338 A COX inhibitor and kinase inhibitor.
SGTC_511 blebbistatin 171 µM -0.094188159393992 0.471479425330814 no 1800 0.462479845196828 603 3476986 A myosin inhibitor.
SGTC_478 N-arachidonylglycine 10 µM -0.0942672442880402 0.471450554456913 no 1801 0.462448434643794 584 5283389
SGTC_234 nsc-17383 10.7 µM -0.095954373716589 0.470834683932324 no 1802 0.461778404892036 585 408974
SGTC_2543 pimpinellin 60.67 µM -0.0963784541293404 0.470679888329582 no 1803 0.46161000178369 593 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1283 0922-0125 16.4 µM -0.096979934320836 0.470460346795363 no 1804 0.461371164709482 586 3360884
SGTC_893 0958-0369 48.9 µM -0.0971031979267972 0.470415356426415 no 1805 0.461322220643603 588 6819948
SGTC_883 0850-0245 24.6 µM -0.0973528761801261 0.470324226737836 no 1806 0.461223083129177 584 6823229 YPR165W RHO1
SGTC_69 0096-0274 206.684 µM -0.0991220511853437 0.469678543023957 no 1807 0.460520681995612 606 6741392
SGTC_920 mycophenolic acid 780.421 nM -0.0992557305248716 0.46962975820718 no 1808 0.460467613354464 590 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1437 4092-1038 11.6 µM -0.100017859318283 0.469351636348032 no 1809 0.460165073427413 594 3977136
SGTC_3302 9125395 16.351 µM -0.100980705759446 0.46900028846867 no 1810 0.459782888224334 607 17599668
SGTC_844 0330-0132 15.3 µM -0.103216025419731 0.468184701759524 no 1811 0.45889576069837 595 2828079
SGTC_995 3931-2021 34.6 µM -0.103803395831732 0.467970413706882 no 1812 0.458662685773266 609 730143
SGTC_45 0kpi-0036 14.9 µM -0.104647576412669 0.467662450873638 no 1813 0.458327730707223 580 2795021
SGTC_514 4466-0038 2.65 nM -0.105223785345294 0.467452257027579 no 1814 0.458099118756076 611 5722064
SGTC_1835 st008666 49.2 µM -0.105792545762932 0.467244789206751 no 1815 0.457873475609522 599 690455
SGTC_50 0929-0078 56.389 µM -0.105825398452681 0.467232805739831 no 1816 0.457860442443791 602 1377751
SGTC_3236 9132701 49.47 µM -0.106542711356819 0.466971163491193 no 1817 0.457575884736184 609 24282524
SGTC_2968 9090663 33.37 µM -0.108829703089284 0.46613707154153 no 1818 0.456668782039225 652 25236811
SGTC_740 k014-0057 261 µM -0.1089000851466 0.466111404743128 no 1819 0.456640869555139 598 4012779
SGTC_2312 7706453 155.7 µM -0.108988486402899 0.466079166936303 no 1820 0.456605811226082 608 976098
SGTC_310 1273-0058 1.06 µM -0.109548928038444 0.465874792571139 no 1821 0.456383558145208 591 2734232
SGTC_917 harmaline 728.087 nM -0.109585842755462 0.465861331320831 no 1822 0.456368919437 595 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_237 nikkomycin 200 µM -0.112522216700917 0.46479068520698 no 1823 0.455204677611654 613 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3225 9130819 49.47 µM -0.113164643038616 0.464556480610098 no 1824 0.454950013163077 624 4547121
SGTC_2983 9022671 12.99 µM -0.113274972576126 0.464516259823591 no 1825 0.454906279252508 632 6405161
SGTC_1112 tnp00069 1.16933 µM -0.113791280271645 0.46432804395954 no 1826 0.454701625514665 609 145826
SGTC_770 0389-1121 67.2 µM -0.114156107159542 0.464195054029528 no 1827 0.454557022895717 602 6753108
SGTC_16 erodoxin 22.806 µM -0.114311959637698 0.464138242521732 no 1828 0.454495251113262 607 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1129 3453-1384 223 µM -0.114693547974511 0.463999148632469 no 1829 0.454344014075016 663 1084452
SGTC_1185 1319-0113 81.3 µM -0.114820545888073 0.463952857223764 no 1830 0.454293681749056 600 4672763
SGTC_2153 5569715 200 µM -0.117681517115623 0.462910148645779 no 1831 0.453160006104765 608 2054701
SGTC_175 3793-3120 23.7 µM -0.118093634432192 0.462759969338164 no 1832 0.452996733573213 625 5322297
SGTC_170 4197-0004 226 µM -0.118205791146967 0.462719099326657 no 1833 0.452952300729409 613 218692
SGTC_2247 cerulenin 830 nM -0.119428689851666 0.46227349952929 no 1834 0.452467866368558 585 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1820 st053765 18.6 µM -0.119578080634176 0.46221906775388 no 1835 0.452408692116821 608 3690829
SGTC_1459 k035-0031 35.7 µM -0.119585106399218 0.462216507875304 no 1836 0.452405909210835 589 3877128 YMR208W ERG12
SGTC_1245 0418-0076 17.2 µM -0.120103922630354 0.4620274784797 no 1837 0.452200412538706 629 6790114
SGTC_977 1348-1378 135 µM -0.120538938798295 0.461868988036246 no 1838 0.452028117898837 590 X977
SGTC_2402 5553605 200 µM -0.121142282603528 0.461649180424354 no 1839 0.451789169549401 624 6758546
SGTC_1415 3966-0071 78.1 µM -0.121410876985017 0.461551331042325 no 1840 0.451682801012693 612 2893185
SGTC_2311 7694451 200 µM -0.121807448198596 0.461406863743129 no 1841 0.451525757534753 599 2163142
SGTC_1206 3978-0017 132 µM -0.122325428323124 0.46121817595058 no 1842 0.451320647165677 644 3873677
SGTC_543 3844-1095 191 µM -0.12279024645189 0.461048861234705 no 1843 0.451136599007181 602 4230703
SGTC_3285 9112818 20.8695 µM -0.123132925692664 0.460924041366749 no 1844 0.45100091936461 597 17017947 YPR165W RHO1
SGTC_2008 4012253 172 µM -0.123141168375831 0.460921039041918 no 1845 0.450997655845748 597 603940
SGTC_597 k018-0003 82.8 µM -0.124825450895739 0.460307600924039 no 1846 0.45033086903699 618 6786234
SGTC_3187 9109394 49.47 µM -0.125433696518358 0.460086092909472 no 1847 0.450090106401907 600 17098090
SGTC_415 dibenzyl ketone 100 µM -0.126111939353089 0.459839108251566 no 1848 0.449821658346194 600 7593
SGTC_1999 st074831 12.5 µM -0.126394137150123 0.459736349431074 no 1849 0.449709971405885 654 17112523
SGTC_796 1234-0020 70.7 µM -0.126928647771849 0.459541721408561 no 1850 0.449498436187155 588 46495034
SGTC_287 k060-0039 29.6 µM -0.127879382973159 0.459195560112381 no 1851 0.44912221353821 611 5861974
SGTC_98 0074-0023 107.663 µM -0.128133974614206 0.459102868908494 no 1852 0.449021474895895 648 3563821
SGTC_606 k015-0008 38.6 µM -0.128408354557913 0.459002975709191 no 1853 0.448912909955859 626 1970475
SGTC_68 0986-0284 82.829 µM -0.128661754563553 0.458910722951585 no 1854 0.448812649623763 585 423278 YIL048W NEO1
SGTC_2996 9066192 71.4286 µM -0.128698335545761 0.458897405468856 no 1855 0.448798176249795 618 6472854
SGTC_843 0310-0051 143 µM -0.12890977625187 0.458820430365953 no 1856 0.448714520443871 605 2065037
SGTC_1312 1218-2183 165 µM -0.129638736276257 0.458555063931962 no 1857 0.448426127360421 594 6744073
SGTC_1372 2752-0194 270 µM -0.130098997492872 0.458387522578366 no 1858 0.448244051632623 600 823334
SGTC_418 lividomycin a 100 µM -0.130124100288554 0.45837838503105 no 1859 0.448234121476693 600 72394 An antibiotic.
SGTC_2195 6536160 144.242 µM -0.130979619125445 0.458066984934314 no 1860 0.447895715037991 598 3834386
SGTC_109 0132-0036 33.701 µM -0.131417426232639 0.457907637573364 no 1861 0.447722552037269 584 67274 A color developer.
SGTC_302 1094-0063 18.9 µM -0.131758405043498 0.457783537206812 no 1862 0.447587693803105 614 5440289
SGTC_876 0720-0963 56.8 µM -0.132307197467769 0.457583811035791 no 1863 0.447370657334761 666 765861
SGTC_278 4092-0821 23.9 µM -0.133043835270966 0.457315737724867 no 1864 0.447079356545864 634 877900
SGTC_1042 0350-0096 82 µM -0.133865407756679 0.457016778349387 no 1865 0.446754502321736 602 3122515
SGTC_1488 4013-0813 75.9 µM -0.13418274308344 0.456901310718618 no 1866 0.446629035762325 609 2910057
SGTC_2016 5121758 140 µM -0.135181447889526 0.456537939488117 no 1867 0.446234207442073 621 2795203
SGTC_2887 9044784 58.44 µM -0.135415237267353 0.456452882219977 no 1868 0.44614178874947 608 6465546
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.138470607332608 0.455341462129856 no 1869 0.444934248881789 668 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1804 st050076 49.1 µM -0.138638235914974 0.455280495661908 no 1870 0.444868013584372 601 3895976
SGTC_1489 4065-0444 182 µM -0.138873881500843 0.455194793210261 no 1871 0.44477490524412 601 2877968
SGTC_1070 indatraline 8.81 µM -0.139333985095971 0.455027463154966 no 1872 0.444593117788759 628 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_59 0330-0160 1.33 µM -0.139504523511485 0.454965443924993 no 1873 0.444525740824452 606 4293482
SGTC_392 N-ethylmaleimide 8.33 µM -0.140740210309368 0.454516098038195 no 1874 0.444037589000704 604 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1530 rhein 70.4 µM -0.141682609591151 0.45417344248776 no 1875 0.443665355945661 602 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_926 2268-1401 59.4 µM -0.141811327587323 0.454126643379029 no 1876 0.443614518190021 605 2931578
SGTC_2603 homopterocarpin 100 µM -0.142291122661981 0.453952205774473 no 1877 0.443425029134743 613 101795 A weak amylase inhibitor.
SGTC_65 0798-0905 34.986 µM -0.143132412161486 0.453646362226759 no 1878 0.44309280363753 711 3602145
SGTC_766 1391-0721 126 µM -0.14363526995292 0.45346356572419 no 1879 0.442894244018487 657 1020919 YIL115C NUP159
SGTC_1587 estradiol valerate 56.1 µM -0.144653367272913 0.453093501995767 no 1880 0.4424922796601 608 13791 A steroid.
SGTC_454 lyso-paf C-16 6.67 µM -0.144942953845719 0.452988248869624 no 1881 0.44237795611945 630 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1207 2099-0101 141 µM -0.145402813452044 0.452821115102036 no 1882 0.442196421729084 610 5837381
SGTC_1985 st071382 65.5 µM -0.146482655283261 0.452428684677414 no 1883 0.441770190651349 643 6123237
SGTC_2085 5307070 144.047 µM -0.146652457826169 0.452366980150688 no 1884 0.441703172956217 632 2840351
SGTC_566 0958-0068 16.5 µM -0.146819977595658 0.452306106288064 no 1885 0.441637057861808 645 6815365
SGTC_2332 7982454 138.89 µM -0.146946997908383 0.452259949993126 no 1886 0.441586927788029 614 2981748
SGTC_1030 k029-0042 36.7 µM -0.147387494579823 0.452099888515908 no 1887 0.441413087803191 605 6080581
SGTC_2345 9052315 157.45 µM -0.149632033796822 0.451284420909149 no 1888 0.440527466694094 609 6469265
SGTC_1830 st055982 50.3 µM -0.149887023061742 0.451191793235249 no 1889 0.440426875074306 645 455313 An antimicrobial agent.
SGTC_1693 xanthone 101.9 µM -0.151532737767064 0.450594033292389 no 1890 0.439777743998154 630 7020 An insecticide.
SGTC_1867 st057372 64 µM -0.151869577240746 0.450471699522741 no 1891 0.439644901882964 621 688837
SGTC_3344 9148862 3.898 µM -0.152933850537981 0.45008520642722 no 1892 0.439225220515391 648 4905352
SGTC_291 SEC14.278 35.5 µM -0.153729629418225 0.449796248556038 no 1893 0.438911460789631 616 1068044
SGTC_2266 7929956 200 µM -0.154067258521391 0.449673658981657 no 1894 0.438778351959977 608 2967153
SGTC_717 1532-0246 73.2 µM -0.154988350383532 0.44933924467747 no 1895 0.43841525068705 625 9561992
SGTC_2539 epi(13)torulosol 80 µM -0.155421377489765 0.449182041009821 no 1896 0.438244566069582 646 6708597
SGTC_500 h-89 112 µM -0.156054194923924 0.448952320964623 no 1897 0.437995151540328 653 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1729 st035615 45.989 µM -0.15611945635215 0.448928631283665 no 1898 0.437969431226676 606 17385451
SGTC_833 3852-0053 558 µM -0.156574612503254 0.448763416185315 no 1899 0.437790056007195 632 3123681
SGTC_1494 4358-1428 177 µM -0.157104959980694 0.448570918932625 no 1900 0.437581064314015 648 1564571
SGTC_809 3998-0021 90 µM -0.159454624755963 0.447718220534418 no 1901 0.436655352523992 617 715485
SGTC_1028 k015-0029 4.8 µM -0.160468056517126 0.447350518299126 no 1902 0.436256191364601 605 4588309
SGTC_985 1493-0307 8.71 µM -0.16098092739862 0.447164451193285 no 1903 0.436054211220617 640 3278274
SGTC_3132 9126706 49.47 µM -0.161035638179813 0.447144603068912 no 1904 0.436032665861915 620 850858
SGTC_1085 doxorubicin 7.67 µM -0.161643385718726 0.446924131695749 no 1905 0.43579334485009 617 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1673 st016611 27.3 µM -0.162312136046797 0.446681549418385 no 1906 0.435530029111278 650 5226799
SGTC_3212 9128307 49.47 µM -0.162495743710274 0.446614951120786 no 1907 0.435457739880732 664 27243542
SGTC_3038 9091290 49.47 µM -0.162810555860547 0.446500765746806 no 1908 0.435333798396632 615 25236843
SGTC_2623 humulene 100 µM -0.163717444090179 0.446171853550525 no 1909 0.434976792221727 629 6187145 An anti-inflammatory.
SGTC_2216 7189485 200 µM -0.164420941476355 0.445916733083217 no 1910 0.434699889500442 628 731273
SGTC_20 0481-0013 4.944 µM -0.164775365232367 0.445788211223757 no 1911 0.434560397335586 617 182045
SGTC_1178 0988-0033 191 µM -0.164896727040074 0.445744204068034 no 1912 0.434512634290005 614 5392207
SGTC_2449 5812982 45.77 µM -0.168308390824318 0.444507371916916 no 1913 0.433170336553095 602 776185
SGTC_2709 st078560 56 µM -0.168989293203062 0.444260588318024 no 1914 0.432902531533184 648 17250903
SGTC_2651 TUB2.036 5 µM -0.169161278559912 0.444198258031535 no 1915 0.432834893017594 613 15992207 YFL037W TUB2
SGTC_1252 0493-0875 34.8 µM -0.17039480863225 0.443751247238824 no 1916 0.432349827277405 623 3960963
SGTC_2041 5107442 45.335 µM -0.170929045689168 0.443557670783907 no 1917 0.432139778794337 622 793005
SGTC_778 3456-2434 196 µM -0.173719017122135 0.442546967173167 no 1918 0.431043145633848 630 5539063
SGTC_233 rapamycin 362 pM -0.174860285277511 0.442133635225903 no 1919 0.430594708584691 616 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2282 7944268 200 µM -0.176451691356295 0.441557382530041 no 1920 0.42996954891906 656 2970414
SGTC_2971 9092186 9.93 µM -0.176661395156748 0.441481457380366 no 1921 0.429887183027029 604 25236400
SGTC_2023 5144124 124 µM -0.176962880769069 0.44137230556776 no 1922 0.429768773108327 611 2830192
SGTC_2614 arthonioic acid 13.39 µM -0.178244767362949 0.440908252819529 no 1923 0.429265376666406 646 6710684
SGTC_114 0364-0001 490.298 µM -0.179564605809451 0.440430545981687 no 1924 0.428747196718263 637 4003655
SGTC_225 nsc-122657 1.016 µM -0.180421340790389 0.440120502749752 no 1925 0.428410900850165 661 275685
SGTC_1139 k015-0024 46.9 µM -0.181160376680296 0.439853083047901 no 1926 0.428120847386704 665 2766652
SGTC_2906 7926292 26.41 µM -0.181208220900956 0.439835771589194 no 1927 0.428102071040033 667 2966319
SGTC_2160 5660466 132.927 µM -0.181550340309927 0.439711985989523 no 1928 0.42796781186613 699 2859134
SGTC_2344 7990960 76.95 µM -0.182421245656792 0.439396901756684 no 1929 0.427626076955645 641 140813
SGTC_647 0140-0236 81 µM -0.182819687140159 0.439252762679919 no 1930 0.427469750421342 638 990837
SGTC_2361 9034121 116 µM -0.186117786991741 0.438059962301605 no 1931 0.42617619680601 645 6496917
SGTC_972 1319-0219 195 µM -0.186932864957075 0.437765265106823 no 1932 0.425856635427585 626 23903702
SGTC_1959 st077091 55.8 µM -0.187165108910678 0.437681301976638 no 1933 0.425765590222147 626 821356 YKL052C ASK1
SGTC_2431 5490079 200 µM -0.188373902084664 0.437244332511306 no 1934 0.425291778288517 668 5722345
SGTC_695 3505-6186 243 µM -0.189232483528656 0.436934008359414 no 1935 0.424955304699734 648 1819379
SGTC_2270 7924575 90.91 µM -0.190060848874999 0.436634642235031 no 1936 0.424630724450471 657 1262135
SGTC_2705 st078069 42.8 µM -0.190241401424852 0.436569396468381 no 1937 0.424559984915455 660 1530061
SGTC_3147 9097027 49.47 µM -0.193263633965293 0.43547751835567 no 1938 0.423376252635175 628 25236841
SGTC_2765 myclobutanil 7.74 µM -0.19526396275841 0.434755105540443 no 1939 0.422593153782008 661 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2257 7960413 200 µM -0.202055765298101 0.432303905160255 no 1940 0.419936564365283 630 2974689 YIL048W NEO1
SGTC_1897 st060201 15 µM -0.202127619044123 0.432277986483799 no 1941 0.419908478296279 631 611878
SGTC_2325 6158266 200 µM -0.202734482991394 0.432059093592658 no 1942 0.41967128464222 626 3623240
SGTC_2174 5790901 200 µM -0.203037068703125 0.431949960177083 no 1943 0.419553029474742 642 786020
SGTC_2647 atorvastatin 60.16 µM -0.203910341933161 0.431635026369018 no 1944 0.419211781590278 657 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2251 lansoprazole 556 µM -0.203995975356019 0.431604146205676 no 1945 0.419178321992251 675 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1633 st005664 67.9 µM -0.204305643127403 0.431492480781354 no 1946 0.419057330200795 665 2063822
SGTC_259 usnic acid 108.925 µM -0.205157541767667 0.431185316533775 no 1947 0.418724520293415 695 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1807 st050092 58.9 µM -0.207021558122616 0.43051336415391 no 1948 0.417996511122015 667 5008496
SGTC_2490 carminic acid 95.39 µM -0.208035726335064 0.430147854762775 no 1949 0.417600535987564 667 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1032 k061-1018 98.7 µM -0.208278306053617 0.430060437132638 no 1950 0.417505834738915 678 4005393
SGTC_113 0099-0221 2.5 µM -0.20942170135788 0.429648441877944 no 1951 0.417059526556804 622 89219
SGTC_190 3970-0790 3.722 µM -0.209996097661367 0.429441500735873 no 1952 0.416835359374137 631 2832352
SGTC_214 4373-3496 70 µM -0.210087522020506 0.429408564530189 no 1953 0.416799682073864 658 3779166
SGTC_2737 bleomycin 30.5 nM -0.210186725020445 0.429372826575675 no 1954 0.416760970024052 631 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.210250243209777 0.429349944404678 no 1955 0.416736183704447 621 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_667 1498-1044 59 µM -0.211035959549303 0.429066912922458 no 1956 0.416429605762358 628 6739982
SGTC_3347 9188721 44.724 µM -0.211832832575756 0.428779899815004 no 1957 0.416118726522239 668 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1291 0993-0025 5.79 µM -0.21228323449124 0.428617693311714 no 1958 0.415943037153805 650 4353356
SGTC_270 tamoxifen 5.46 µM -0.212509997000018 0.428536032248959 no 1959 0.415854589706795 656 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2926 9010726 65.15 µM -0.212791649303009 0.428434608691857 no 1960 0.415744738737847 680 2994293
SGTC_1715 st032160 10.2275 µM -0.212988724331696 0.42836364439056 no 1961 0.415667878793432 663 5289825
SGTC_725 1497-0963 19 µM -0.213486197217053 0.42818452081324 no 1962 0.415473877000113 615 3549977
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.21356780417622 0.428155138250697 no 1963 0.415442054324071 652 390807
SGTC_825 1988-2224 89.6 µM -0.214026799810038 0.427989884427875 no 1964 0.415263079076798 651 1180859
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.214300645311833 0.427891296875784 no 1965 0.415156307420688 638 23665772 A membrane-active detergent.
SGTC_747 3448-8087 38.7 µM -0.214934166111503 0.427663239313619 no 1966 0.414909323319328 675 5168703
SGTC_1930 st074634 34.3 µM -0.215055489316125 0.42761956761559 no 1967 0.414862028149365 665 684253 YOR116C RPO31
SGTC_2167 5876490 200 µM -0.216344234429331 0.427155723673498 no 1968 0.414359715652846 642 686534
SGTC_85 0868-0259 160.055 µM -0.216902401387708 0.426954859952805 no 1969 0.414142203059416 664 83173
SGTC_2101 5377231 179.231 µM -0.217828817726609 0.426621518676164 no 1970 0.41378124518063 675 2844213
SGTC_2772 vinpocetine 57.06 µM -0.218158186490273 0.42650301848091 no 1971 0.413652931375749 629 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1468 k284-1086 134 µM -0.219029938170744 0.426189411966864 no 1972 0.41331336332605 647 15996457
SGTC_1482 3346-2049 8.48 µM -0.219856805123264 0.425891995539889 no 1973 0.412991338853161 669 3826804
SGTC_679 0422-0091 41.4 µM -0.222677186672948 0.424877848364906 no 1974 0.411893378991066 639 627384 YHR062C RPP1
SGTC_21 0849-0113 22.993 µM -0.222763721029605 0.424846740337724 no 1975 0.411859702473441 634 1560156
SGTC_1330 1469-0054 61.8 µM -0.223683447771445 0.424516138948331 no 1976 0.411501813196895 663 7102664
SGTC_1201 1889-3372 45.9 µM -0.224226582997922 0.424320930598222 no 1977 0.41129049989919 642 5392199
SGTC_358 0075-0058 9.45 µM -0.224493945176263 0.424224844714527 no 1978 0.411186488873234 732 1069125
SGTC_1939 st074455 53.6 µM -0.226994516753865 0.423326396269718 no 1979 0.41021400294433 674 1644229
SGTC_1006 4099-6547 255 µM -0.227918775956875 0.42299441312579 no 1980 0.409854692872658 648 3146833
SGTC_187 1488-2104 32.728 µM -0.229690667798943 0.422358123281152 no 1981 0.409166073533992 641 2852859
SGTC_1767 st044992 70.3 µM -0.230130441811091 0.422200230881522 no 1982 0.408995205246048 656 9600693
SGTC_2086 5274770 176.623 µM -0.231324204597268 0.421771696417766 no 1983 0.408531472010079 648 689278
SGTC_1955 wogonin 32.4 µM -0.232537569240325 0.421336220234216 no 1984 0.408060255383679 640 5281703 A flavanone.
SGTC_3013 9080133 71.4286 µM -0.232716721244104 0.421271930775401 no 1985 0.407990691995307 646 17050193
SGTC_592 k241-0073 46.5 µM -0.234166460468508 0.420751763046141 no 1986 0.407427875930185 672 4230158
SGTC_2034 5197015 53.07 µM -0.234180520881589 0.420746718833235 no 1987 0.407422418346623 696 780676
SGTC_3242 9133940 49.47 µM -0.23481928157444 0.420517575366451 no 1988 0.407174500796788 673 17248444
SGTC_2928 9011484 9.79 µM -0.234864229113806 0.420501452289626 no 1989 0.407157057033859 674 2994751
SGTC_3107 9121808 49.47 µM -0.235118460447548 0.420410259790568 no 1990 0.407058395453542 636 662681
SGTC_1199 1638-0010 4.46 µM -0.235364877913466 0.420321874194065 no 1991 0.406962771891315 647 3111136
SGTC_1610 st001799 48.1 µM -0.235423913593071 0.420300699733977 no 1992 0.406939863616153 637 621897
SGTC_545 4218-0007 221 µM -0.235760512632687 0.420179975407198 no 1993 0.406809255410478 676 2840508
SGTC_2621 lithochol-11-enic acid 100 µM -0.235768980673167 0.42017693836375 no 1994 0.406805969748679 681 6708711
SGTC_2555 cholic acid 100 µM -0.236734672279036 0.419830626486585 no 1995 0.406431317408907 657 6708657 Influences liver metabolism.
SGTC_1524 corynanthine 62.1 µM -0.238727127669472 0.419116297751772 no 1996 0.40565859000302 693 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_501 nsc-95397 161 µM -0.238962527862607 0.419031920387308 no 1997 0.405567319737653 670 262093
SGTC_1638 st008370 60.6 µM -0.23956329048095 0.418816598597651 no 1998 0.405334413033626 641 24207134
SGTC_381 3461-2219 42.7 µM -0.240013519460873 0.418655246123404 no 1999 0.405159887943044 696 2883159
SGTC_2515 chrysin 20.77 µM -0.24006133507333 0.418638110829981 no 2000 0.405141353983691 654 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1264 0783-0040 158 µM -0.242741754416888 0.417677798492525 no 2001 0.404102729645571 645 2855798
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.245338054507039 0.416748091280132 no 2002 0.403097344342213 668 4174840
SGTC_1360 1598-0022 39.8 µM -0.245516627203245 0.416684163361809 no 2003 0.403028217718043 678 761525
SGTC_1107 amlodipine 47 µM -0.24612864269295 0.416465082336233 no 2004 0.402791325642403 673 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1432 4049-0298 68.4 µM -0.246449755747327 0.416350145003165 no 2005 0.402667047077971 665 741646
SGTC_2807 7945238 51.95 µM -0.246654898940602 0.416276720989121 no 2006 0.402587656818887 689 17148797
SGTC_932 2857-0803 154 µM -0.246801439975159 0.41622427340918 no 2007 0.402530948009913 673 674898
SGTC_262 fenpropimorph 62.5 µM -0.248418495493792 0.415645622492409 no 2008 0.401905312336833 663 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_226 1,3-diallylurea 8.28947 mM -0.248706983377466 0.415542408501794 no 2009 0.401793723297281 658 74537 YKL182W FAS1
SGTC_557 1315-0110 16.2 µM -0.24897973151115 0.415444831171779 no 2010 0.40168822986078 644 6833801
SGTC_1509 1326-1131 80 µM -0.249894581837933 0.415117575924707 no 2011 0.401334436696339 631 768313
SGTC_1831 st055328 12 µM -0.250757674567697 0.41480888909837 no 2012 0.401000733491968 681 1103068
SGTC_943 3253-1379 105 µM -0.254876535123041 0.41333649802524 no 2013 0.399409230063899 684 668464
SGTC_701 4424-0219 185 µM -0.25492444890126 0.413319377157923 no 2014 0.399390726239318 676 2911779
SGTC_1672 st016598 6.51 µM -0.255533948132685 0.413101601266689 no 2015 0.399155363435808 693 4665860 YNL267W PIK1
SGTC_3153 9100258 49.47 µM -0.258992636240682 0.411866309952171 no 2016 0.397820461065631 695 25236848
SGTC_1922 5578187 25 µM -0.259283447404367 0.411762484604631 no 2017 0.39770827493914 629 1350412
SGTC_765 1319-0117 244 µM -0.260399005998901 0.411364265442674 no 2018 0.397278004806456 639 3487746 YGL099W LSG1
SGTC_2779 methotrexate 400 µM -0.260610426079856 0.411288805434262 no 2019 0.397196474307483 670 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1413 3910-0535 34.4 µM -0.260719127377029 0.411250009068663 no 2020 0.397154557279883 660 2876951
SGTC_2684 capsaicin 100 µM -0.260728241695566 0.411246756134641 no 2021 0.397151042701081 684 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1736 st036774 51 µM -0.261246563570917 0.411061775186103 no 2022 0.396951185988145 711 1272247
SGTC_83 0170-0301 39.027 µM -0.261522376058739 0.410963350092962 no 2023 0.39684484808535 649 3089716
SGTC_1331 1472-0049 76.2 µM -0.263249958164337 0.410346981353083 no 2024 0.396178963617541 656 24051409
SGTC_195 4234-0266 16.654 µM -0.263422081967059 0.410285582926643 no 2025 0.396112636253872 670 2303354
SGTC_2351 9026858 72.31 µM -0.264273047132708 0.409982066764632 no 2026 0.395784763737128 678 1409300
SGTC_2427 5545055 42.75 µM -0.265088930732952 0.409691113876849 no 2027 0.395470477194451 665 5372858
SGTC_1676 st018489 23.4 µM -0.268751375466232 0.408385661395655 no 2028 0.394060506883658 660 3696235
SGTC_1761 st044296 37 µM -0.269580649385976 0.408090213139594 no 2029 0.393741444452836 675 1826700
SGTC_710 3448-4187 58 µM -0.27049413506079 0.407764822954348 no 2030 0.393390064181195 649 3946412
SGTC_1721 st082152 9.2685 µM -0.270714231181156 0.407686432630724 no 2031 0.393305415247263 660 5296051
SGTC_2506 ethyl hematommate 54.16 µM -0.271821919458765 0.40729197006564 no 2032 0.392879475147749 667 3940691 An allergen.
SGTC_1970 st070122 35.8 µM -0.272281637579147 0.407128285892107 no 2033 0.392702737062304 712 102928
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.273523971165832 0.406686030076715 no 2034 0.392225234153469 692 15053
SGTC_2386 9075165 157.42 µM -0.273851089384521 0.406569599691967 no 2035 0.392099530062425 667 16452277
SGTC_3201 9113999 49.47 µM -0.274694281529565 0.406269522487249 no 2036 0.391775562450209 694 16649224
SGTC_404 fumagillin 50 µM -0.274877182294055 0.406204438591934 no 2037 0.391705299010571 665 12015870 A methionine aminopeptidase binder.
SGTC_1071 trifluoperazine 6.31 µM -0.275367783502522 0.406029874555056 no 2038 0.391516846345383 686 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_732 3970-1727 52.7 µM -0.275829971915472 0.405865437349817 no 2039 0.391339331060707 689 1275699
SGTC_633 0437-0093 97.7 µM -0.276566569453559 0.40560340531345 no 2040 0.391056468715875 675 2831118
SGTC_1568 digitonin 820 nM -0.276657046067481 0.405571222712349 no 2041 0.39102172857458 701 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3033 9090887 49.47 µM -0.277292906162664 0.405345064806255 no 2042 0.39077760307257 658 19325384
SGTC_2874 9043904 71.43 µM -0.279181215264737 0.404673631857912 no 2043 0.390052879392425 670 4463428
SGTC_474 dl-dihydrosphingosine 5 µM -0.279576268274535 0.404533196846575 no 2044 0.389901308238428 659 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3254 9136651 49.47 µM -0.279814614595215 0.404448474497824 no 2045 0.389809869297292 687 16454030
SGTC_408 cantharidin 100 µM -0.282847115710615 0.403370937065937 no 2046 0.388647017637525 649 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2801 7907800 81.82 µM -0.283427841667626 0.403164671335956 no 2047 0.388424444221054 704 6620925
SGTC_1366 1683-0113 21.9 µM -0.284563358487917 0.402761429547577 no 2048 0.387989343371827 675 708623
SGTC_1768 st044301 37.178 µM -0.284845429531762 0.402661277228797 no 2049 0.387881282776729 692 3931349
SGTC_422 cantharidin 155 µM -0.285799710087198 0.40232249718216 no 2050 0.387515765093481 651 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2015 5119600 184 µM -0.286581571482901 0.402044982483589 no 2051 0.387216363323579 704 2828786
SGTC_3337 9144342 33.5465 µM -0.288665858636918 0.401305425041333 no 2052 0.386418545896427 652 17682949
SGTC_1295 1013-0063 9.78 µM -0.289343898313266 0.401064915592627 no 2053 0.386159111115461 675 6826038
SGTC_808 0711-0032 135 µM -0.289460369347846 0.401023605579641 no 2054 0.386114551530535 706 4252555
SGTC_1254 0550-0035 264 µM -0.290902758021081 0.400512110190147 no 2055 0.385562845949336 698 15121435
SGTC_3308 9128332 17.569 µM -0.295265969887573 0.398965883286469 no 2056 0.383895355164789 679 17332805 YDL196W YDL196W
SGTC_1055 3448-0672 86 µM -0.295427286297049 0.398908746496058 no 2057 0.383833745770534 703 748378
SGTC_692 k241-0027 77.8 µM -0.29580044903092 0.398776583986486 no 2058 0.383691240028987 691 3600480
SGTC_2337 9009472 200 µM -0.296074663442519 0.398679473258898 no 2059 0.383586531322618 691 5742383
SGTC_1841 st054148 70 µM -0.296372366310849 0.398574051393704 no 2060 0.383472863179143 711 675442
SGTC_318 1488-0629 67.2 µM -0.296768370996295 0.398433830582628 no 2061 0.383321677232767 692 3662576
SGTC_2619 obliquin 87.91 µM -0.296827443463205 0.398412914809061 no 2062 0.383299126176392 671 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1657 st012939 43.4 µM -0.297702082438771 0.398103265785372 no 2063 0.382965276951041 677 24207257
SGTC_671 0560-0003 407 µM -0.298235399169021 0.397914486782955 no 2064 0.382761752884897 682 3238678
SGTC_519 k048-0011 62.8 µM -0.299899293195131 0.397325669249857 no 2065 0.382126986739497 671 6836379
SGTC_2079 5212404 121 µM -0.301065268522996 0.396913194104016 no 2066 0.381682362365754 685 758462
SGTC_761 k216-0224 480 µM -0.301525538548889 0.396750400807687 no 2067 0.381506889340516 742 1340404
SGTC_1824 st053723 68.6 µM -0.301879677007244 0.396625157522328 no 2068 0.381371894414559 705 675225
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.30388871833495 0.395914849684072 no 2069 0.380606336528142 691 1377
SGTC_738 1315-0003 72.4 µM -0.306037938033759 0.395155363509538 no 2070 0.379787880149665 726 6251474
SGTC_1317 1273-0028 910 nM -0.306476699133265 0.395000363991292 no 2071 0.379620859115192 693 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2884 9058502 51.95 µM -0.30658145269369 0.39496336054268 no 2072 0.379580986411286 704 6471554
SGTC_2519 cryptotanshinone 88.04 µM -0.307403389016941 0.394673050299161 no 2073 0.379268174466533 683 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_576 1073-0113 22.7 µM -0.307519972784559 0.394631877313384 no 2074 0.379223811493819 698 5439563
SGTC_1506 4226-2149 212 µM -0.307864169771918 0.394510326799061 no 2075 0.379092845409924 699 991114
SGTC_1428 4049-0204 61.7 µM -0.3078788714031 0.394505135259893 no 2076 0.379087251785337 696 X1428
SGTC_1987 st072290 61.9 µM -0.308080658294526 0.394433880805633 no 2077 0.379010479182313 691 54697379
SGTC_2854 9024559 71.43 µM -0.309067875255007 0.394085328314164 no 2078 0.378634947731675 712 3163529
SGTC_348 k064-0012 10.7 µM -0.309599369843505 0.393897710885143 no 2079 0.378432817777652 676 5066323
SGTC_2191 5911152 200 µM -0.310021986944785 0.393748544747949 no 2080 0.378272118190605 678 2875902
SGTC_2048 5246248 200 µM -0.310071449636719 0.393731087507876 no 2081 0.37825331144395 661 677046
SGTC_1678 st019265 80.2 µM -0.310320062880863 0.393643345800054 no 2082 0.378158787874702 713 5367020
SGTC_2359 9039622 200 µM -0.310726325891413 0.393499977249111 no 2083 0.378004341045035 679 6463596
SGTC_1548 st061468 90.8 µM -0.310928470953822 0.393428646463369 no 2084 0.377927499903033 683 390799
SGTC_794 k038-0031 316 µM -0.31189633118677 0.393087167905618 no 2085 0.377559655408676 659 6624242
SGTC_2541 muurolladie-3-one 83.07 µM -0.311915998807566 0.393080229665831 no 2086 0.377552181692107 709 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_136 0097-0015 404.482 µM -0.311966035463571 0.393062578150708 no 2087 0.377533167916954 682 4861337
SGTC_2479 5617353 43.85 µM -0.312431879827207 0.392898252009451 no 2088 0.377356162743839 699 2731746
SGTC_2546 rhodinyl acetate 100 µM -0.312522998944091 0.392866112061318 no 2089 0.377321543558474 688 6708682
SGTC_1208 2323-2347 50.3 µM -0.313020215978212 0.392690744286724 no 2090 0.377132651631335 702 5412760
SGTC_518 1021-0119 62.6 µM -0.313537744312607 0.392508235879827 no 2091 0.376936074697962 710 1097762
SGTC_3065 9113888 49.47 µM -0.31413137081402 0.392298920262013 no 2092 0.376710632065542 720 16648368
SGTC_90 0870-0863 4.608 µM -0.314666299063754 0.392110328621473 no 2093 0.376507517381081 700 1738164
SGTC_2395 5646831 180.19 µM -0.314926095768099 0.392018745128549 no 2094 0.376408883723305 722 6808628
SGTC_672 1441-0018 53.7 µM -0.315894484725099 0.391677421553105 no 2095 0.376041299148513 678 251141
SGTC_2965 9082772 38.63 µM -0.316416652369027 0.391493410118655 no 2096 0.375843139506607 665 16459634
SGTC_1039 k821-0043 94 µM -0.316810521280514 0.391354627109215 no 2097 0.375693690159322 709 15992768
SGTC_956 1185-0240 191 µM -0.316908661132717 0.391320048862043 no 2098 0.375656454942924 686 1416193
SGTC_153 4077-0274 519.67 µM -0.317655397070612 0.391056974721082 no 2099 0.375373174002165 648 3121976
SGTC_3085 9117376 49.47 µM -0.317817707949592 0.390999799390493 no 2100 0.375311608806234 682 16480349
SGTC_1746 st038117 42 µM -0.31993387472536 0.390254578402762 no 2101 0.374509229039475 673 2898218
SGTC_455 paf C-16 10 µM -0.321275287365095 0.389782400345325 no 2102 0.374000891183544 698 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1983 st071813 46.9 µM -0.323072392093387 0.389150073366535 no 2103 0.373320208991211 692 11838595
SGTC_1690 st023502 41.2 µM -0.324608438512264 0.388609834564847 no 2104 0.372738719903875 691 24207482
SGTC_294 k038-0071 157 µM -0.324911115111215 0.388503406351661 no 2105 0.37262417213718 681 24152826
SGTC_1146 3579-1023 7 µM -0.327582221621978 0.387564546163112 no 2106 0.371613782973806 687 X1146
SGTC_202 3594-0513 34.79 µM -0.328303976835747 0.38731097086009 no 2107 0.371340918796716 683 708429
SGTC_913 3487-1245 167 µM -0.328991157113199 0.387069587491482 no 2108 0.371081185971332 668 4016153
SGTC_3100 9120536 49.47 µM -0.331316611201473 0.386253057941282 no 2109 0.37020267264392 728 16421196
SGTC_760 0568-0725 82.9 µM -0.331517206378566 0.386182647111637 no 2110 0.370126923153714 707 3916171
SGTC_1275 0867-0008 21.1 µM -0.335063542928948 0.384938469904418 no 2111 0.368788576680093 706 3422836
SGTC_863 0466-0191 129 µM -0.338377316644693 0.383776953238691 no 2112 0.367539432860167 704 765160 YPR165W RHO1
SGTC_1171 0368-0077 21.4 µM -0.342429114273392 0.382358169149601 no 2113 0.366013990669614 681 3239779
SGTC_1874 staurosporine 7.6 µM -0.34515726977572 0.381403761366693 no 2114 0.364988070378697 710 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2358 9037157 4 µM -0.345425462446632 0.381309976655035 no 2115 0.364887268797305 690 2388925
SGTC_2711 st079103 59.1 µM -0.34637460687227 0.380978124879844 no 2116 0.364530603075023 696 54693780
SGTC_2183 6420625 130.508 µM -0.347269783993782 0.380665222023044 no 2117 0.364194324395472 684 2897619
SGTC_1380 2291-0730 164 µM -0.348176503961517 0.380348364004215 no 2118 0.363853816129564 704 2999191
SGTC_851 0394-0702 453 µM -0.348250857035552 0.380322384493122 no 2119 0.363825898451781 693 762646
SGTC_1926 methyl fluorone black 53.6 µM -0.348699570613194 0.380165612131415 no 2120 0.363657433328549 675 72721 Reacts with homocysteine.
SGTC_292 k038-0015 474 µM -0.348910627259058 0.380091879584313 no 2121 0.363578203287911 725 46368540
SGTC_3127 9126946 49.47 µM -0.350023928343531 0.379703020513782 no 2122 0.363160369982053 712 27243249
SGTC_160 3453-0671 289.699 µM -0.351471414384332 0.379197617652493 no 2123 0.362617357128245 742 5322268
SGTC_3216 9129716 49.47 µM -0.352044939053637 0.37899742336543 no 2124 0.362402280258411 684 8056934
SGTC_326 k292-0812 17.5 µM -0.35260561101121 0.378801746810246 no 2125 0.36219206524207 718 3579357
SGTC_636 0kpi-0074 126 µM -0.352967938252575 0.3786753098029 no 2126 0.362056238517008 693 616434
SGTC_2988 9073640 71.4286 µM -0.35351177388655 0.378485558355644 no 2127 0.36185240178995 723 9102229
SGTC_618 k072-0232 33.2 µM -0.354166265185718 0.378257236529296 no 2128 0.361607141828119 731 5872756 YGL099W LSG1
SGTC_3282 9108498 15.4605 µM -0.354665311395544 0.378083170881127 no 2129 0.361420170574971 717 16459645
SGTC_1486 3970-0793 4.53 µM -0.355462256094974 0.377805250559786 no 2130 0.361121658140383 716 2844330
SGTC_2155 5570423 76 µM -0.355796034304723 0.377688870113725 no 2131 0.360996659589035 718 797402
SGTC_2666 tannic acid 100 µM -0.355971834687702 0.377627577205232 no 2132 0.360930829043927 706 16134267 A thiamine antagonist.
SGTC_482 fipronil 114 µM -0.35627278811513 0.377522656766616 no 2133 0.360818143015748 677 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3243 9134147 49.47 µM -0.35767919014085 0.377032467208414 no 2134 0.36029170403241 717 24282180
SGTC_1279 0874-0590 65.2 µM -0.35995546075735 0.376239512403561 no 2135 0.3594402206107 699 3523074
SGTC_2297 7971671 152.32 µM -0.360205425275608 0.376152467269783 no 2136 0.359346758933512 732 909016
SGTC_2571 chrysanthemic acid 100 µM -0.360941345979893 0.375896234224247 no 2137 0.3590716472222 755 2743 An insecticide.
SGTC_1137 ixabepilone 100 µM -0.361986769983723 0.375532332331637 no 2138 0.358680958505477 669 154225 A novel microtubule stabilizer.
SGTC_2407 paclitaxel 400 µM -0.362328547313399 0.375413386976292 no 2139 0.358553263861503 768 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2196 6573537 42.6665 µM -0.363659696583143 0.374950233353907 no 2140 0.358056071499706 737 2903087
SGTC_1661 st013063 9.66 µM -0.366060381734605 0.374115406732859 no 2141 0.357160009783848 718 721395
SGTC_2165 5727197 32.143 µM -0.366368803142478 0.374008197372009 no 2142 0.357044947687058 712 1361712
SGTC_119 0121-0043 24.815 µM -0.366559331934877 0.37394197314809 no 2143 0.356973874024968 725 1092378
SGTC_2568 diosmetin 100 µM -0.368494956158193 0.373269397800504 no 2144 0.356252102688356 748 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_762 1165-0429 115 µM -0.369862028479497 0.372794610772566 no 2145 0.355742647569392 737 5967793
SGTC_2456 5770359 74.46 µM -0.370722872351062 0.372495736999689 no 2146 0.355421976354715 744 3118787
SGTC_3346 9158254 43.5805 µM -0.371712392288776 0.372152283414086 no 2147 0.355053498696621 715 17639500
SGTC_2871 9038510 12.99 µM -0.372980924022051 0.371712136070352 no 2148 0.354581320812735 766 4945164
SGTC_2557 derrustone 83.84 µM -0.374363297968057 0.371232679348175 no 2149 0.354067022472283 753 629853 An antioxidant.
SGTC_1730 st033808 45.1 µM -0.374979827903177 0.371018909089804 no 2150 0.353837734452605 721 1045166
SGTC_2888 9058547 12.99 µM -0.376920386906371 0.370346316482836 no 2151 0.353116385180755 696 16476514
SGTC_2375 9072683 200 µM -0.37762930658691 0.370100705496206 no 2152 0.352852995258486 744 16798029
SGTC_1927 st060202 13.8 µM -0.377717332005476 0.370070212068819 no 2153 0.352820295472975 689 688887
SGTC_1856 st057054 55.7 µM -0.377872412203994 0.370016491769178 no 2154 0.352762688744416 742 1266018
SGTC_137 0438-0332 85.389 µM -0.378590384489063 0.369767816830878 no 2155 0.352496031815662 740 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2426 5582046 32.21 µM -0.379628676889474 0.369408293020235 no 2156 0.352110535309347 723 2251934
SGTC_135 0933-0004 26.348 µM -0.3798653250774 0.369326366116501 no 2157 0.352022693974714 713 21230617 YGL099W LSG1
SGTC_1475 4092-1048 11.7 µM -0.38035067807335 0.369158356912508 no 2158 0.3518425607229 731 2881759
SGTC_2299 7976368 114.88 µM -0.383084533544702 0.36821247650678 no 2159 0.350828543480943 713 2979718
SGTC_146 3448-8650 53.125 µM -0.383724837290233 0.367991054447037 no 2160 0.350591200910598 738 2891488 YIL048W NEO1
SGTC_2790 5423970 71.43 µM -0.385648133068328 0.367326227632737 no 2161 0.349878640258651 718 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_122 0236-0016 402.397 µM -0.386337258794672 0.367088113756369 no 2162 0.349623454945308 723 6808838
SGTC_654 1124-0271 80.9 µM -0.386808002352764 0.366925486933034 no 2163 0.349449176245182 722 5403748
SGTC_3194 9111903 49.47 µM -0.386879388893026 0.366900827254012 no 2164 0.349422750287199 750 17087251
SGTC_2977 9011197 71.43 µM -0.388993837667738 0.366170664116956 no 2165 0.348640352467933 754 2704722
SGTC_2505 galangin 7.89 µM -0.389380230464581 0.366037286909767 no 2166 0.348497447100038 724 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2081 5214970 32.255 µM -0.390004510796246 0.365821828572955 no 2167 0.348266605699235 713 2063512
SGTC_2088 5278280 127.392 µM -0.390552916636359 0.365632591766549 no 2168 0.348063866926614 720 791502
SGTC_2466 5983409 37.09 µM -0.391410552859078 0.365336715296631 no 2169 0.347746896616952 720 2879657
SGTC_1884 5633444 25 µM -0.391754528363765 0.365218069470562 no 2170 0.347619797978326 704 5724239
SGTC_2415 st077333 57.7 µM -0.392944707539394 0.364807646257685 no 2171 0.34718016007196 725 2766255
SGTC_2187 6125751 200 µM -0.393257441830372 0.364699828159959 no 2172 0.347064673858912 720 874498
SGTC_659 k018-0002 107 µM -0.394989153199759 0.364102998210547 no 2173 0.346425446494581 724 6797879 YHR007C ERG11
SGTC_378 3970-0959 8.33 µM -0.395982023772378 0.363760956369749 no 2174 0.346059144790256 748 6615653
SGTC_86 0417-1630 471.922 µM -0.396605455420957 0.363546240923994 no 2175 0.345829214489488 717 3634867
SGTC_1912 st060209 90.8 µM -0.39755371524725 0.363219733928548 no 2176 0.345479592031867 754 688787
SGTC_2565 isoliquiritigenin 100 µM -0.397558615861399 0.363218046795754 no 2177 0.345477785522335 683 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_264 promethazine 12.5 mM -0.397624646143274 0.363195314831476 no 2178 0.345453445174766 734 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2124 5246320 200 µM -0.399860582968934 0.362425843270139 no 2179 0.344629602950749 722 579342
SGTC_3324 9138759 60.749 µM -0.401761273374807 0.361772179450387 no 2180 0.343929862759322 727 45595710
SGTC_3075 9116269 49.47 µM -0.401889431666719 0.361728119194063 no 2181 0.343882700413571 738 17015205 YNL244C SUI1
SGTC_2458 5808907 16.39 µM -0.404690406662185 0.360765615066028 no 2182 0.34285254736417 742 2731747
SGTC_411 enrofloxacin 100 µM -0.405418915756445 0.360515420326647 no 2183 0.342584804537419 722 71188 A bacterial gyrase inhibitor.
SGTC_1334 1486-0610 236 µM -0.408001770729975 0.3596288620314 no 2184 0.341636187448509 689 3742339
SGTC_946 3434-1334 87.4 µM -0.408511228604666 0.359454080919132 no 2185 0.341449194306475 709 4047976
SGTC_714 4296-0578 26.1 µM -0.408755359075676 0.35937033682546 no 2186 0.341359601621124 720 1589775
SGTC_1973 st070275 50.2 µM -0.409706308753688 0.35904419691966 no 2187 0.3410107008201 726 17118334
SGTC_544 k015-0020 52.4 µM -0.409877993581196 0.358985326431899 no 2188 0.340947724608597 718 3008304
SGTC_2890 9046729 58.44 µM -0.413332443495369 0.357801513685322 no 2189 0.339681531488038 728 903329
SGTC_3039 9090270 49.47 µM -0.414946997362649 0.357248686642683 no 2190 0.339090352116136 711 17173750
SGTC_971 1315-0384 26.7 µM -0.41705034962886 0.35652894323667 no 2191 0.338320790106481 741 6769120
SGTC_1167 k781-0610 148 µM -0.41879384354982 0.355932726212943 no 2192 0.33768340228052 727 4525169
SGTC_1603 st002045 67.8 µM -0.419736264447274 0.355610596090497 no 2193 0.337339064935522 734 5887985
SGTC_1353 1498-1206 8.11 µM -0.419785154891307 0.355593887594782 no 2194 0.337321205286942 735 6756808
SGTC_2412 st077135 33.4 µM -0.421943386257451 0.354856580700763 no 2195 0.336533170453887 763 13258915
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.422574874018071 0.354640950986422 no 2196 0.336302730891274 729 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.423180890209862 0.354434062659143 no 2197 0.336081644108322 759 5393153
SGTC_470 aa-861 153 µM -0.423926374440551 0.35417962014248 no 2198 0.335809754375686 707 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1783 st039459 87.517 µM -0.424160186653289 0.354099830693335 no 2199 0.335724497105223 771 729761
SGTC_1636 st007707 68.9 µM -0.42526003079765 0.353724590013171 no 2200 0.335323563496603 760 403051
SGTC_890 0929-0006 47.2 µM -0.42572044422257 0.353567550060407 no 2201 0.335155781529084 729 1378169
SGTC_417 st075190 100 µM -0.425723491439976 0.353566510784302 no 2202 0.33515467118415 742 222757
SGTC_2327 6189656 200 µM -0.426627809267998 0.353258134740537 no 2203 0.334825219577305 755 5349088
SGTC_3305 9127027 53.8275 µM -0.427225327933899 0.353054431289281 no 2204 0.334607607540323 734 41905295
SGTC_952 1185-0122 232 µM -0.427544231329929 0.352945729366472 no 2205 0.334491487926723 722 678600
SGTC_293 4049-0273 38.5 µM -0.429463328257802 0.352291836605731 no 2206 0.333793037921833 727 1380311
SGTC_390 dec-rvkr-cmk 16.7 µM -0.431803504290274 0.351495060438632 no 2207 0.332942116196769 722 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2021 4019055 173 µM -0.432261615014434 0.351339160471915 no 2208 0.332775641004309 753 44827708 YER133W GLC7
SGTC_567 1080-0542 68.4 µM -0.432297444551046 0.35132696835251 no 2209 0.332762622115749 708 5950415
SGTC_3222 9128301 49.47 µM -0.432894730414064 0.351123745715169 no 2210 0.332545624232566 736 4911358
SGTC_552 k242-0005 476 µM -0.43294167625619 0.351107774500799 no 2211 0.332528570876459 765 4088318
SGTC_2685 mycophenolic acid 18.85 µM -0.437737151054024 0.349477719572779 no 2212 0.33078841758053 718 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3326 9140064 16.379 µM -0.440409342181416 0.348570601657776 no 2213 0.32982032993073 746 1868434
SGTC_2420 aureobasidin a 50 nM -0.441553024965906 0.348182624369873 no 2214 0.329406341483595 736 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2526 patulin 37.61 µM -0.44348712010989 0.347526873094766 no 2215 0.328706716674461 733 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2374 9071832 200 µM -0.443627171962426 0.347479406463884 no 2216 0.328656078652082 753 17381698
SGTC_2148 5546263 113.568 µM -0.444747418411217 0.347099816606866 no 2217 0.328251148644305 719 792097
SGTC_116 0155-0182 31.788 µM -0.445060725751089 0.34699368142253 no 2218 0.328137935047448 737 771486
SGTC_2896 9052656 71.43 µM -0.447539716730677 0.346154328633985 no 2219 0.327242709037661 753 6469436
SGTC_1982 st072467 71.9 µM -0.44912105883633 0.345619301823337 no 2220 0.326672164910431 751 3163533
SGTC_816 0325-0417 81.3 µM -0.449136839383895 0.3456139642291 no 2221 0.326666473369217 729 68101
SGTC_493 zm226600 134 µM -0.450349240502863 0.345203974904931 no 2222 0.32622931956624 764 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2755 lomerizine 42.69 µM -0.451191771880216 0.344919168800702 no 2223 0.325925669687414 730 3949 A calcium channel blocker.
SGTC_288 1315-0019 35.1 µM -0.453899366747716 0.344004499163439 no 2224 0.324950629688405 741 6811474
SGTC_2104 5389443 200 µM -0.454228037215151 0.34389353089887 no 2225 0.324832352589118 754 2244536
SGTC_2381 9035592 200 µM -0.454686767463626 0.343738673326341 no 2226 0.324667301007995 745 4749657
SGTC_2788 5282734 71.43 µM -0.456353333311314 0.343176296943545 no 2227 0.324067958924273 772 743706
SGTC_712 r015-0009 80.6 µM -0.457237021252973 0.342878240519883 no 2228 0.323750345652183 720 6813872 YLR060W FRS1
SGTC_1966 st070145 16.1 µM -0.458162512380284 0.342566189231288 no 2229 0.323417845125081 738 3748532
SGTC_1209 2323-2347 50.3 µM -0.459343765690843 0.342168057718741 no 2230 0.322993661906581 716 5412760
SGTC_2238 6671620 73.2395 µM -0.460340676965965 0.341832193581718 no 2231 0.32263585417696 714 729941
SGTC_2168 5727979 200 µM -0.462252255430447 0.341188523971097 no 2232 0.321950216902802 726 695210
SGTC_1740 st038286 13.222 µM -0.462304968331521 0.34117078093761 no 2233 0.321931318622343 712 716786
SGTC_797 k781-0471 270 µM -0.463101908001671 0.340902575803002 no 2234 0.32164566122256 714 23738129
SGTC_2753 fluvastatin 17.09 µM -0.464105889013513 0.340564806620463 no 2235 0.321285941372568 739 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_367 0335-0881 7.1 µM -0.464149943740576 0.340549988220832 no 2236 0.321270160686946 772 23828853
SGTC_2119 5528445 120.635 µM -0.464168629738516 0.340543703008586 no 2237 0.321263467340166 743 791935
SGTC_2973 9094665 17.96 µM -0.467496093877542 0.339425186423929 no 2238 0.320072493048075 768 25237061 YIL048W NEO1
SGTC_258 haloperidol 50.781 µM -0.467861848576346 0.339302325161543 no 2239 0.319941693950564 743 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3056 9094900 49.47 µM -0.467965411641154 0.339267540224703 no 2240 0.319904662386464 748 25236784
SGTC_2335 9018011 154.17 µM -0.467981121573464 0.339262263665793 no 2241 0.319899045063995 727 6458208
SGTC_1150 3909-7983 10.9 µM -0.468054717409459 0.339237545152521 no 2242 0.319872730316373 741 23965914
SGTC_2581 avocatin a 64 µM -0.468183770925176 0.339194201829244 no 2243 0.319826588444483 783 6710728 A skin care supplement.
SGTC_440 fluspirilene 35.1 µM -0.468555209795847 0.339069463947252 no 2244 0.319693799527665 752 3396 An atypical antipsychotic.
SGTC_210 3551-0445 56.827 µM -0.468942189510855 0.338939525847082 no 2245 0.319555479358293 771 2865180 YOR207C RET1
SGTC_1313 1220-0047 237 µM -0.469447470182431 0.338769894090012 no 2246 0.319374912046911 740 3528706
SGTC_801 0866-0028 10.1 µM -0.470515417543791 0.338411472677664 no 2247 0.318993410890411 747 6849771
SGTC_2495 cafestol 54.53 µM -0.472256658928117 0.337827396204306 no 2248 0.31837180110134 769 16667697 An anti-infammatory.
SGTC_3238 9133470 49.47 µM -0.476638035669184 0.336359450276074 no 2249 0.316809946903585 743 3534688
SGTC_2663 amphotericin b 100 µM -0.47679268290535 0.33630768231964 no 2250 0.31675487832309 750 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2960 9079389 5.97 µM -0.477617467157294 0.336031639324385 no 2251 0.31646124818477 748 16457355
SGTC_3265 9137266 49.47 µM -0.478552581301745 0.335718777501867 no 2252 0.316128479570986 720 17224265
SGTC_1027 k015-0025 8.67 µM -0.478720325779589 0.335662667144883 no 2253 0.316068801961778 743 3598955
SGTC_1641 st009299 47.1 µM -0.478746218539087 0.335654006369607 no 2254 0.316059590651865 728 4046054
SGTC_2372 9071633 200 µM -0.47878748142467 0.335640204676987 no 2255 0.316044911678886 739 21321366
SGTC_2514 salinomycin 42.74 µM -0.479447064397382 0.335419616154151 no 2256 0.315810309189345 752 23682228 A polyether potassium ionophore.
SGTC_1422 4031-0024 15.5 µM -0.481003972581704 0.334899154543506 no 2257 0.315256837658924 771 782427
SGTC_1399 3562-5772 25 µM -0.483047084222248 0.334216640058726 no 2258 0.314531152491573 760 23847490
SGTC_1647 st011722 22.4 µM -0.483193894352253 0.33416761826632 no 2259 0.314479035090756 756 2854783
SGTC_1402 3909-7673 35.9 µM -0.483654047372007 0.334013985580186 no 2260 0.314315705338369 730 5328014
SGTC_2010 4012422 159 µM -0.484706436176596 0.333662725908563 no 2261 0.313942300163671 741 952393
SGTC_1089 terbinafine 2.25 µM -0.484981453489165 0.333570956379415 no 2262 0.313844750785807 752 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1559 coumarin 343 70.1 µM -0.485026761913786 0.333555838530837 no 2263 0.313828681014258 774 108770 A hepatotoxic, DNA x-linker.
SGTC_2905 7799065 20.05 µM -0.485828156284094 0.333288485735778 no 2264 0.313544504745385 775 1296806
SGTC_2682 pyrogallin 40.03 µM -0.486523976554714 0.333056422139609 no 2265 0.313297855008055 753 822798 An ATP competetive kinase inhibitor.
SGTC_1658 st012944 20 µM -0.488638780598905 0.332351504720157 no 2266 0.312548726185793 769 24207260
SGTC_2908 7930301 100 µM -0.489950934359175 0.331914428583285 no 2267 0.312084309656762 760 2223178
SGTC_1017 4239-0030 168 µM -0.493894696625648 0.330602146485107 no 2268 0.310690275095331 732 1149593
SGTC_1511 0906-3109 28.5 µM -0.493999774598022 0.330567210292551 no 2269 0.310653169335864 734 2882180
SGTC_1012 4112-3522 18 µM -0.49525297007606 0.330150663298044 no 2270 0.310210782035307 746 3112398
SGTC_1250 0485-0349 40.2 µM -0.496783758015688 0.329642133480896 no 2271 0.309670775004499 759 6842794 YDL195W SEC31
SGTC_1100 amiodarone 5.07 µM -0.49733302583104 0.32945974266746 no 2272 0.30947711306069 741 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_979 1426-2828 121 µM -0.497781153078592 0.329310966810878 no 2273 0.30931915064037 765 747872
SGTC_2377 9073351 62.6 µM -0.498012152891287 0.329234286658024 no 2274 0.309237738221587 783 7337946 YHR072W ERG7
SGTC_713 1488-1073 324 µM -0.502368747287982 0.327789467819693 no 2275 0.30770407937874 771 3312542
SGTC_63 0099-0242 26.702 µM -0.503768072239121 0.327325941512402 no 2276 0.30721218318054 771 3898502 YLR359W ADE13
SGTC_1898 st060199 18.6 µM -0.505031988240844 0.32690749811599 no 2277 0.306768184389262 745 688866
SGTC_1708 st033234 31.827 µM -0.506466225859319 0.32643293002835 no 2278 0.306264696814532 755 674664
SGTC_2193 5925765 200 µM -0.507186244210963 0.326194792388046 no 2279 0.306012072936478 756 877370
SGTC_617 3770-0098 35 µM -0.507809465671779 0.325988726383252 no 2280 0.30579348544592 774 5962639
SGTC_1066 ketoconazole 628 nM -0.509859916798818 0.325311127121256 no 2281 0.305074802657942 779 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_759 3486-0358 89.3 µM -0.509860610297386 0.325310898042799 no 2282 0.305074559713715 799 875103
SGTC_1540 guanosine 70.6 µM -0.510787605794483 0.325004749246277 no 2283 0.304749894415266 763 6802 Guanosine is a purine nucleoside
SGTC_2567 aureobasidin a 60 nM -0.510974365358502 0.324943084470824 no 2284 0.304684503469126 755 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1900 st060200 72.8 µM -0.512737180805872 0.324361269788362 no 2285 0.304067588808503 745 688945
SGTC_580 1123-0028 41 µM -0.513754856575502 0.324025582378553 no 2286 0.303711696797086 768 1677248 YPR107C YTH1
SGTC_199 4063-0024 41.6 µM -0.515932618274419 0.323307713412024 no 2287 0.302950735750594 763 306215
SGTC_2891 9063876 19.48 µM -0.516524366379044 0.323112765314261 no 2288 0.302744112606658 774 6472478
SGTC_3283 9109332 35.8195 µM -0.51747548886777 0.32279952513707 no 2289 0.302412137551585 752 17027281
SGTC_1154 4088-0362 150 µM -0.517988308512259 0.32263068660019 no 2290 0.302233213305064 768 6618304
SGTC_780 0109-0199 192 µM -0.518974031733952 0.322306254033533 no 2291 0.301889425135248 788 610414
SGTC_2050 5263056 171 µM -0.520656729387077 0.321752737962515 no 2292 0.301302961363324 761 763468 YGL055W OLE1
SGTC_3178 9107506 49.47 µM -0.523064225785916 0.320961490163416 no 2293 0.300464779783068 762 8897194
SGTC_1169 aniline yellow 25.8 µM -0.524090851087325 0.320624326334911 no 2294 0.300107675799026 771 6051 A DNA damaging agent.
SGTC_539 4859-0462 2.54 µM -0.525098407564492 0.320293568918215 no 2295 0.299757391529817 753 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1600 coumarin 106 71.1 µM -0.525634290669441 0.320117709049496 no 2296 0.299571163366352 791 100336 A hepatotoxic, DNA x-linker.
SGTC_3117 9124945 49.47 µM -0.526621585364636 0.319793816003005 no 2297 0.29922819963386 767 17592065
SGTC_1650 st011916 45.8 µM -0.526939516368742 0.319689544414141 no 2298 0.299117795565926 795 242528
SGTC_1456 k015-0012 13 µM -0.529093849997457 0.318983365032619 no 2299 0.298370173753187 775 2989616
SGTC_2354 9060492 162 µM -0.530723297995694 0.318449676339787 no 2300 0.297805269403689 781 6471895
SGTC_372 0155-0182 15.9 µM -0.530807765139408 0.318422021300149 no 2301 0.297775999258273 756 771486
SGTC_1225 1216-0074 20.6 µM -0.53150221010608 0.318194694297927 no 2302 0.297535405091358 779 4241466
SGTC_3114 9122766 49.47 µM -0.533005406113154 0.317702856696048 no 2303 0.297014919017175 748 17176985
SGTC_3044 9093193 49.47 µM -0.535067254150457 0.31702875422451 no 2304 0.296301676210802 792 25236277
SGTC_486 niguldipine 82 µM -0.536261611875958 0.316638547220242 no 2305 0.295888878741454 765 1236 A calcium channel blocker.
SGTC_658 3253-0951 102 µM -0.536550072522216 0.316544335193717 no 2306 0.29578921972547 770 1184878
SGTC_3200 9114385 49.47 µM -0.538031036168541 0.316060835978225 no 2307 0.295277811013033 760 17018030 YLR208W SEC13
SGTC_1424 4048-1941 275 µM -0.538367315645344 0.315951092545051 no 2308 0.295161743169591 770 X1424
SGTC_2793 7325131 81.82 µM -0.5390638080384 0.31572384668846 no 2309 0.29492141362219 756 4176441
SGTC_282 k297-0036 65.7 µM -0.540416653333285 0.315282650435039 no 2310 0.294454862811275 782 5061378
SGTC_1296 1068-0102 11.9 µM -0.541116140124411 0.315054633741811 no 2311 0.294213767047392 768 767053
SGTC_546 peri-Naphthalide 147 µM -0.541982235099545 0.314772404225027 no 2312 0.293915372004169 759 223824 A penicillin ester.
SGTC_2073 5212005 126 µM -0.54227022885147 0.314678581268345 no 2313 0.293816180752275 792 691789
SGTC_1060 3448-7350 82 µM -0.543555093937597 0.314260142167327 no 2314 0.293373834328271 786 570178
SGTC_393 acivicin 6.25 µM -0.543873244064868 0.314156567768883 no 2315 0.293264350999965 779 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_407 eburnamonine 100 µM -0.544593739232032 0.313922063259358 no 2316 0.293016480827081 787 3195
SGTC_2057 5236571 38.335 µM -0.544885930812934 0.313826983066943 no 2317 0.292915986587678 768 54684039 YBR257W POP4
SGTC_206 4546-0025 72.014 µM -0.545461194332299 0.313639826377295 no 2318 0.292718181412844 812 6620745 YIL048W NEO1
SGTC_365 0121-0052 13.6 µM -0.546860089006351 0.313184909046534 no 2319 0.292237428534541 752 3101739
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.547974509134776 0.31282270550194 no 2320 0.291854703017978 769 688761
SGTC_3080 9117754 49.47 µM -0.548010677350863 0.312810953304417 no 2321 0.291842285673417 797 9550191
SGTC_2638 epoxomicin 18 µM -0.548802599027601 0.312553680606656 no 2322 0.291570463243469 762 9915668 A protesome inhibitor.
SGTC_867 0518-0118 155 µM -0.54885415881338 0.312536933472324 no 2323 0.29155276974604 786 6848158
SGTC_3266 9136860 49.47 µM -0.550011434023895 0.312161140813356 no 2324 0.291155765572443 766 4871271 YPR165W RHO1
SGTC_1240 0356-0016 42.1 µM -0.550019931270271 0.312158382293 no 2325 0.29115285151915 756 4305613
SGTC_3185 9108267 49.47 µM -0.550226459007453 0.312091338992219 no 2326 0.291082028900331 782 4910486
SGTC_1426 4048-4480 71.7 µM -0.551969029124939 0.311525911584035 no 2327 0.290484786298928 775 14224343
SGTC_821 1114-0266 29.2 µM -0.553141251897534 0.311145799719385 no 2328 0.290083345582827 777 3123235
SGTC_313 3474-0040 5.03 µM -0.553809366401521 0.31092924301994 no 2329 0.289854658740486 777 1043375 YIL048W NEO1
SGTC_777 1315-0167 517 µM -0.555296330566597 0.310447506718245 no 2330 0.289345994161227 773 4221767
SGTC_252 miconazole 1.30953 nM -0.556242514752987 0.310141137662575 no 2331 0.28902253952834 784 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3234 9132280 49.47 µM -0.5571591255379 0.309844469926127 no 2332 0.288709356905708 773 17612295
SGTC_3149 9097855 49.47 µM -0.558314482514072 0.309470706618431 no 2333 0.288314828594429 765 25236625 YMR079W SEC14
SGTC_167 3672-0051 66.205 µM -0.558429862316359 0.309433391533481 no 2334 0.288275442963986 768 3237971
SGTC_1466 k213-0079 57.5 µM -0.560817250975958 0.308661725439229 no 2335 0.287461062646284 811 3657981
SGTC_1814 st052110 31.539 µM -0.56203804024832 0.308267460564317 no 2336 0.287045050774935 795 674163
SGTC_1198 1612-1005 86.7 µM -0.562252607431822 0.308198186993592 no 2337 0.28697196156989 781 6998509
SGTC_3063 1327-0034 4 µM -0.562357728120856 0.308164250999966 no 2338 0.286936156946677 788 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2761 levamisole 97.89 µM -0.563364438370387 0.307839338947364 no 2339 0.2865933737206 800 26879 An alkaline phosphatase inhibitor.
SGTC_1271 0832-2808 169 µM -0.564431271434658 0.307495186841836 no 2340 0.286230330887517 788 3663794
SGTC_1188 1403-0014 4.57 µM -0.56503683480809 0.307299912116145 no 2341 0.286024355146149 777 9614867
SGTC_219 mitoxanthrone 164.414 µM -0.565426150300535 0.307174399223017 no 2342 0.2858919709606 798 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2150 5556613 200 µM -0.566636283370607 0.306784404118128 no 2343 0.285480659243037 786 743190
SGTC_2866 9034245 58.44 µM -0.570776117376064 0.305451896047145 no 2344 0.284075707010208 770 6462273
SGTC_1452 4194-0072 190 µM -0.571038725651635 0.305367455686369 no 2345 0.28398669624692 793 1343545
SGTC_1246 0422-0085 105 µM -0.57223975861419 0.304981401648403 no 2346 0.283579777721408 801 264295
SGTC_3016 9080866 49.47 µM -0.572580781490252 0.304871824486184 no 2347 0.283464287684562 796 17066299
SGTC_1315 1237-0019 3.69 µM -0.573441760795344 0.304595253266611 no 2348 0.283172810726705 774 825140
SGTC_8 0354-0001 70 µM -0.574914888238923 0.304122301562964 no 2349 0.282674430165422 778 4993152
SGTC_360 0957-0399 1.01 µM -0.57500863202037 0.304092215936059 no 2350 0.28264272954396 799 6752301 YPR165W RHO1
SGTC_1365 1672-3266 55.4 µM -0.575545482003718 0.303919947733609 no 2351 0.282461219987051 781 6415873
SGTC_128 0906-2981 13.371 µM -0.576249496514212 0.303694104582888 no 2352 0.282223276912771 799 6740226
SGTC_2972 9093619 59.92 µM -0.576654618711756 0.303564178051884 no 2353 0.282086397311199 757 25236256
SGTC_2188 6126565 140.678 µM -0.576923890541303 0.303477833756446 no 2354 0.281995435484582 779 874518
SGTC_1212 0520-0165 585 µM -0.577290767130597 0.303360209326409 no 2355 0.281871524858156 835 5403258
SGTC_2949 9072542 2.23 µM -0.578584501613093 0.302945587361572 no 2356 0.281434782379162 807 16457352
SGTC_3061 glucosamine 200 µM -0.579309932666869 0.302713208927924 no 2357 0.281190032314108 786 91431 and experimental redox chemotherapeutic
SGTC_3010 9080089 71.4286 µM -0.58068997790107 0.302271357532817 no 2358 0.280724708752003 786 17027233
SGTC_3173 9105693 49.47 µM -0.582779094222022 0.301603032883561 no 2359 0.280021010071512 822 17096658
SGTC_338 4055-0136 114 µM -0.582814517642224 0.301591706387016 no 2360 0.280009085410649 786 2900563
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.582988713054319 0.301536010886754 no 2361 0.279950449222777 778 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2598 perillyl alcohol 100 µM -0.583480996662485 0.30137863806958 no 2362 0.279784773069017 773 10819 An apoptosis inducer.
SGTC_1022 4477-0945 21.3 µM -0.583623403402758 0.301333120496538 no 2363 0.279736855500484 780 4648966
SGTC_55 0767-0285 6.563 µM -0.583758564067236 0.301289921855449 no 2364 0.279691379802996 811 3116166
SGTC_3158 9100007 49.47 µM -0.58675389925153 0.300333300748279 no 2365 0.27868450132158 780 19297233
SGTC_1272 0839-0021 27 µM -0.586900844871673 0.300286406020956 no 2366 0.27863515116833 791 5027250
SGTC_1875 nocodazole 6 µM -0.587471386491629 0.300104360564052 no 2367 0.278443581066085 793 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2696 st077691 74.316 µM -0.590207250157707 0.299232109834121 no 2368 0.277525856012825 807 757133
SGTC_2825 7998094 58.44 µM -0.590846532896503 0.299028459003349 no 2369 0.277311626639679 780 2987815
SGTC_1709 st033179 39.1045 µM -0.591268694217375 0.298894009196756 no 2370 0.277170200948478 789 573381
SGTC_2634 4'-methoxyflavone 100 µM -0.591997606547882 0.29866193009364 no 2371 0.276926095566616 776 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1166 k206-0078 225 µM -0.592101456202737 0.298628871970676 no 2372 0.276891325934358 781 5404595
SGTC_329 k048-0121 21.3 µM -0.595216927969121 0.297637908710173 no 2373 0.275849238158779 784 6832902
SGTC_2482 5981709 142.65 µM -0.597159183927646 0.297020880102026 no 2374 0.275200553501709 804 877755
SGTC_3309 9129340 25.759 µM -0.597450902104783 0.296928255717493 no 2375 0.275103188872321 790 17158987
SGTC_1119 parthenolide 318.541 nM -0.597798176437069 0.296818008751874 no 2376 0.2749873037971 823 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1015 4130-4525 82 µM -0.598163514171337 0.296702047540822 no 2377 0.274865416948647 790 1363237
SGTC_2848 9016370 25.97 µM -0.598422201924121 0.296619950460962 no 2378 0.274779127611077 785 7894410
SGTC_33 0986-0033 35.816 µM -0.599382957449983 0.296315136452061 no 2379 0.274458769562148 767 2848082
SGTC_1294 1000-1494 117 µM -0.599879881424628 0.296157536292796 no 2380 0.274293145656967 782 712797 YDL207W GLE1
SGTC_2659 sanguinarine 24.21 µM -0.602976637228488 0.295176263468736 no 2381 0.273262115675272 812 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_506 n9-isopropylolomoucine 153 µM -0.607426558808795 0.293768838453953 no 2382 0.271783933710608 805 6610355
SGTC_853 0419-0306 21 µM -0.607849583200249 0.293635205713706 no 2383 0.271643620198687 801 762713
SGTC_2391 6285546 200 µM -0.60850911926747 0.293426915464533 no 2384 0.271424929793839 802 846083
SGTC_1160 4092-0570 10.5 µM -0.609304551626011 0.293175798457626 no 2385 0.271161295340519 808 4994975
SGTC_207 4185-0010 4.486 µM -0.609508917129874 0.293111296615451 no 2386 0.271093581997015 798 3761753
SGTC_595 3909-8003 73.7 µM -0.609714262262648 0.293046492212524 no 2387 0.271025552563416 814 699517
SGTC_154 3389-1638 511.116 µM -0.610798670148661 0.29270437667502 no 2388 0.270666436961125 835 5238686
SGTC_1383 3049-0032 20.7 µM -0.611251151500779 0.29256167999984 no 2389 0.270516662242079 811 712864
SGTC_1273 0849-0096 14.1 µM -0.612857146457478 0.292055466943788 no 2390 0.269985400398833 813 5286025
SGTC_2499 avocadenofuran 51.48 µM -0.614804260786843 0.291442279733373 no 2391 0.26934199756039 806 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_634 1611-4317 11.2 µM -0.615906969317756 0.291095280232334 no 2392 0.268977960782044 811 2843522
SGTC_1797 st048695 56.8 µM -0.625252260141768 0.28816228788312 no 2393 0.265902753642593 832 592262 YIL048W NEO1
SGTC_1605 st000082 49.1 µM -0.62534629084021 0.288132847601961 no 2394 0.265871902210121 799 1114022
SGTC_916 4466-0038 42 nM -0.626539320219191 0.287759442660881 no 2395 0.265480627349734 818 5722064 YGL116W CDC20
SGTC_103 0844-0104 51.839 µM -0.629767859030045 0.286750094012583 no 2396 0.264423238634993 809 5375804
SGTC_3047 9092122 49.47 µM -0.631386852280627 0.286244575491817 no 2397 0.263893805284246 815 17173831
SGTC_406 estrone 100 µM -0.631941510884404 0.286071484876359 no 2398 0.263712548552069 811 5870 A steroid.
SGTC_100 0086-0128 49.5915 µM -0.632335406921768 0.285948593151089 no 2399 0.263583865945648 838 93297
SGTC_2177 5811945 192 µM -0.637082347110311 0.284469571153389 no 2400 0.262035603241169 804 5343475
SGTC_2157 5649910 96.377 µM -0.637811185472037 0.284242808275913 no 2401 0.261798298713043 811 2858091
SGTC_2764 methyldopa 94.69 µM -0.638736911314282 0.283954912607049 no 2402 0.261497048048929 818 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1913 st060213 96.1 µM -0.638765339152546 0.283946073913725 no 2403 0.261487799849721 827 688959
SGTC_1390 3413-2614 145 µM -0.63988349569496 0.283598524703295 no 2404 0.261124172257872 836 3421432
SGTC_3073 9114972 49.47 µM -0.640263377732399 0.283480494879466 no 2405 0.261000692747079 791 41905075
SGTC_2570 licareol 100 µM -0.641529787560065 0.283087189923597 no 2406 0.260589267032035 813 443158
SGTC_609 0986-0026 86.3 µM -0.6416151552125 0.283060686981885 no 2407 0.260561545176779 810 2848610
SGTC_425 3825-7017 13.1 µM -0.641880212977678 0.2829784056684 no 2408 0.260475481349031 813 3397440
SGTC_1810 st050138 53 µM -0.64197312806246 0.282949564956275 no 2409 0.260445315436866 841 3444541
SGTC_896 0964-0007 44.5 µM -0.642216587011602 0.282874002333944 no 2410 0.260366282324863 800 6756758
SGTC_373 0844-0104 25.9 µM -0.642989049384886 0.282634316511454 no 2411 0.260115602742063 813 5375804
SGTC_2785 7756463 72.73 µM -0.645331797691114 0.281907987307877 no 2412 0.259356095379162 842 2201551
SGTC_2199 6590217 200 µM -0.64620634396026 0.281637079830627 no 2413 0.259072865799559 788 703109
SGTC_2997 9067075 71.4286 µM -0.646851135294242 0.281437423782862 no 2414 0.258864146872054 819 27209819
SGTC_1161 k007-0610 110 µM -0.646951584962629 0.281406326251792 no 2415 0.258831639152961 825 5843850
SGTC_458 nppb 133 µM -0.646961975254814 0.281403109686389 no 2416 0.258828276746738 812 4549 A chloride channel blocker.
SGTC_2934 9036370 36.88 µM -0.647357369754835 0.2812807189743 no 2417 0.258700339786702 804 6462800
SGTC_2852 9023854 51.95 µM -0.64838379763683 0.280963117715294 no 2418 0.258368373548199 833 19798528
SGTC_3180 9109287 49.47 µM -0.648570069635799 0.280905499302679 no 2419 0.258308153322872 809 18891271
SGTC_1423 4048-0112 5.59 µM -0.651318876236885 0.280055891962262 no 2420 0.257420332888288 802 X1423
SGTC_1401 3807-4679 7.6 µM -0.654397514871029 0.279105820571406 no 2421 0.256427867533632 833 3291456
SGTC_3129 9127257 49.47 µM -0.655211198686061 0.278854978897116 no 2422 0.256165892571417 829 837894
SGTC_130 0136-0219 337.655 µM -0.655696550651886 0.27870540730504 no 2423 0.256009694342191 860 234244
SGTC_159 3970-0959 50 µM -0.655901974203533 0.278642113408729 no 2424 0.255943598946827 816 6615653
SGTC_1750 st081859 2.357 µM -0.65649326594928 0.278459967152897 no 2425 0.255753399480657 825 5291695
SGTC_2413 inermin 26.06 µM -0.65664171122921 0.278414247989326 no 2426 0.255705661017056 833 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_27 0485-0001 32.618 µM -0.657483172588874 0.278155158286144 no 2427 0.255435143726242 816 2054479
SGTC_3322 9139058 2.11 µM -0.658258930457081 0.277916403203801 no 2428 0.255185881679823 800 4908926 YPR165W RHO1
SGTC_1860 st056228 74.6 µM -0.658649885510417 0.277796116843949 no 2429 0.255060310475882 844 688679
SGTC_2923 7992654 58.14 µM -0.658939773332102 0.277706942569844 no 2430 0.254967222020193 803 2985126
SGTC_2759 disulfiram 3.38 µM -0.65936420305894 0.277576406212586 no 2431 0.254830961691246 813 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_308 4092-1169 104 µM -0.663074206121787 0.2764366467361 no 2432 0.253641514768887 830 2268590 YDL196W YDL196W
SGTC_628 1636-0253 16 µM -0.663285147552347 0.276371911902859 no 2433 0.253573973531301 823 4456143
SGTC_2862 9027634 71.43 µM -0.663427720554684 0.276328162549861 no 2434 0.253528328500234 809 5012562
SGTC_277 nystatin 15.5 µM -0.664317432630867 0.276055226016071 no 2435 0.253243582957241 838 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2858 9025781 8.96 µM -0.665110234900049 0.27581213003449 no 2436 0.252989994410962 811 4894980 YPL153C RAD53
SGTC_222 nsc-310342 10.666 µM -0.666361473357379 0.275428678476166 no 2437 0.252590040858143 825 432556
SGTC_3202 9113761 49.47 µM -0.666827288432696 0.275285992922588 no 2438 0.252441229991428 822 4798415
SGTC_1642 st009582 77.7 µM -0.666974701300865 0.275240845916916 no 2439 0.252394146601905 836 6739311
SGTC_1837 st055472 66.5 µM -0.667326224478006 0.275133202327438 no 2440 0.252281889449765 809 676091
SGTC_1196 1588-0294 184 µM -0.669680732503765 0.274412738711658 no 2441 0.251530668386474 832 6144269
SGTC_2315 7733312 200 µM -0.670051818692166 0.274299273836414 no 2442 0.251412378840368 820 726316
SGTC_2438 5259590 200 µM -0.670546575753467 0.274148030874123 no 2443 0.251254713007551 819 1201127
SGTC_2237 6667747 47.222 µM -0.670566725394625 0.274141872175892 no 2444 0.251248292964422 827 729940 YDL015C TSC13
SGTC_2531 methyl deoxycholate 70.07 µM -0.671445327395075 0.273873395682756 no 2445 0.2509684387195 834 16667744 Haematoxylin.
SGTC_443 clozapine 122 µM -0.671566185912431 0.273836474832753 no 2446 0.250929955508847 834 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_269 exalamide 29 µM -0.671666121844204 0.27380594744461 no 2447 0.250898136730298 818 3316 A derivative of salicylamide.
SGTC_1764 st044502 93.5 µM -0.671733045814065 0.273785505147856 no 2448 0.250876829882838 816 8407
SGTC_1668 st014914 51.6 µM -0.672061560523048 0.273685169460495 no 2449 0.250772253254893 829 2839556
SGTC_70 0141-0289 43.283 µM -0.672492897746745 0.273553457121481 no 2450 0.25063498002316 816 352408
SGTC_2360 9040895 200 µM -0.673981717182984 0.273099075118078 no 2451 0.250161468645858 807 4914414
SGTC_2322 7413319 38.22 µM -0.674026797995999 0.273085322463055 no 2452 0.250147138329459 819 1840400
SGTC_1029 k015-0030 64.7 µM -0.67483954064705 0.272837440635465 no 2453 0.249888857902998 826 2208316
SGTC_156 3474-0145 5.642 µM -0.675264345333744 0.272707922079924 no 2454 0.249753916126202 811 2265471
SGTC_1435 4092-0789 56.7 µM -0.675783424260524 0.272549701711698 no 2455 0.249589080108511 832 2248285
SGTC_626 0214-0009 33 µM -0.679987293025831 0.271270002707382 no 2456 0.248256253408851 838 3437874
SGTC_2602 kawain 100 µM -0.680849638343886 0.271007866985714 no 2457 0.247983318702046 823 5369129
SGTC_1177 0983-0204 23.6 µM -0.681106184621306 0.270929906446493 no 2458 0.247902152001238 824 766818
SGTC_742 0kpi-0133 140 µM -0.681944931318682 0.270675102117274 no 2459 0.247636886382528 828 2728852
SGTC_2700 st077718 96.8 µM -0.685655941126682 0.269549165958407 no 2460 0.246465048134473 827 904970
SGTC_866 0495-0101 262 µM -0.687682771740582 0.268935209450122 no 2461 0.24582628573601 815 635694
SGTC_650 1328-0195 38 µM -0.689505409888054 0.268383706006403 no 2462 0.245252634995481 839 2780821
SGTC_1233 0325-0408 14.2 µM -0.690295963907999 0.268144672985156 no 2463 0.24500404275518 835 12874
SGTC_764 1951-2361 146 µM -0.690358402249106 0.268125798607114 no 2464 0.244984414596857 824 5438930
SGTC_2305 7443522 69.23 µM -0.691328054458749 0.267832769969282 no 2465 0.244679702701842 824 5415886
SGTC_847 0342-0274 5.54 µM -0.691508238572464 0.267778336157914 no 2466 0.244623102580926 837 18097
SGTC_1798 st045719 60.953 µM -0.691579485496189 0.267756813924734 no 2467 0.244600724170976 818 3980186
SGTC_503 tyrphostin 8 294 µM -0.693952181271316 0.267040569439403 no 2468 0.243856098869794 855 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3089 9117425 49.47 µM -0.695073508731077 0.266702411858463 no 2469 0.243504617788114 852 9401657
SGTC_1666 st014829 29 µM -0.695101589750717 0.266693946272966 no 2470 0.243495819281477 831 3858230
SGTC_2736 butenafine 14.65 µM -0.695479319659091 0.266580085234787 no 2471 0.243377483467044 831 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3101 9120531 49.47 µM -0.695525391983582 0.266566199102974 no 2472 0.243363051984086 856 24824904
SGTC_3340 9146634 11.102 µM -0.695606612532041 0.266541720238246 no 2473 0.243337611959372 816 4907387
SGTC_857 0438-0306 1.35 µM -0.696249820572314 0.266347905480483 no 2474 0.243136196117726 827 4686136
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.698134015124433 0.265780561019804 no 2475 0.242546693700241 843 94937 An inhibitor of serotonin biosynthesis.
SGTC_798 1287-0182 476 µM -0.69982925338889 0.265270636683683 no 2476 0.242016971710121 861 1649755
SGTC_9 0092-0002 10.449 µM -0.701076306069822 0.264895843016922 no 2477 0.24162769805636 843 759368
SGTC_2432 5630864 12.22 µM -0.701662844920227 0.264719655644353 no 2478 0.241444724667574 848 5714970
SGTC_1917 st066507 28.5 µM -0.702016487336282 0.264613455631011 no 2479 0.241334440730729 833 3156428
SGTC_604 1000-0114 314 µM -0.703126605228035 0.264280224328636 no 2480 0.240988426622511 847 1572745
SGTC_2798 7813637 45.45 µM -0.703761851884821 0.264089634378221 no 2481 0.240790547188456 834 956368
SGTC_1583 clindamycin 39.6 µM -0.704606468644504 0.263836336633477 no 2482 0.240527585915119 847 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.705125980017056 0.263680598458595 no 2483 0.240365919998033 832 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1096 rimcazole 32.2 µM -0.706959733996892 0.263131254165755 no 2484 0.239795750524659 847 18528119 A dopamine reuptake inhibitor.
SGTC_2369 9071472 200 µM -0.709542586392202 0.262358492856216 no 2485 0.238993916910986 851 17296037
SGTC_831 k061-1017 217 µM -0.710935048438691 0.261942366083036 no 2486 0.238562242962827 848 1240153
SGTC_2269 7935389 174.42 µM -0.712347497768571 0.261520612271989 no 2487 0.238124809169547 832 97605
SGTC_1522 st012842 45.6 µM -0.712532927425694 0.261465269343023 no 2488 0.238067414493853 842 3491067 YOR116C RPO31
SGTC_2127 5253358 187.912 µM -0.712574724241532 0.261452795587556 no 2489 0.23805447848056 832 20612
SGTC_2958 9077254 16.72 µM -0.713586545850491 0.261150922897463 no 2490 0.237741439723181 833 16457351
SGTC_306 1672-3436 11.6 µM -0.71453545857779 0.260867981664928 no 2491 0.237448069103715 858 6797378
SGTC_81 0411-0046 9.971 µM -0.717046148443498 0.260120120144293 no 2492 0.236672811052858 841 12925265
SGTC_2588 indole-3-carbinol 100 µM -0.717062277269289 0.260115319411298 no 2493 0.236667835252729 836 3712 Induces cell cycle arrest.
SGTC_2645 abamectin 100 µM -0.71760949386966 0.259952467864673 no 2494 0.236499051086271 820 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1217 1183-1422 255 µM -0.72307854659578 0.258327772764381 no 2495 0.234815814400309 838 2849664
SGTC_807 1315-0151 48 µM -0.723787990273959 0.25811740409099 no 2496 0.234597951771541 856 4011080
SGTC_2625 euphol 100 µM -0.724294793363537 0.257967178084006 no 2497 0.234442386400186 834 6708538 A triterpene alcohol.
SGTC_1420 4'-methoxyflavone 42 µM -0.726501383023514 0.257313632262271 no 2498 0.23376572998055 829 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1277 0873-0036 22 µM -0.727987042269213 0.256874096217804 no 2499 0.233310759180909 850 5965735
SGTC_533 1222-0222 6.71 µM -0.727989216570234 0.256873453231796 no 2500 0.233310093679583 867 3982874
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.728089906132259 0.256843678152794 no 2501 0.233279276176659 842 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2116 5511452 16.8835 µM -0.729610854738096 0.256394134474734 no 2502 0.232814042651089 857 870744
SGTC_1553 gossypol 38.6 µM -0.73042272236355 0.256154340371125 no 2503 0.232565916695614 831 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2967 9089538 49.85 µM -0.730530002549329 0.256122662729077 no 2504 0.232533140333799 852 728216
SGTC_502 l-744,832 89.3 µM -0.730647256143339 0.256088042480695 no 2505 0.232497319823123 874 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_642 0335-0876 158 µM -0.732706677450258 0.255480376721724 no 2506 0.231868675208668 848 6812350
SGTC_1106 tegaserod maleate 11.7 µM -0.732782402297448 0.255458047242429 no 2507 0.231845578028827 846 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2211 7117706 200 µM -0.735435432459518 0.25467637512731 no 2508 0.231037174699933 843 822771
SGTC_1880 MG-132 525 µM -0.735955923012326 0.254523168170424 no 2509 0.230878761131634 836 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2605 digitonin 300 nM -0.736453178282633 0.254376845657827 no 2510 0.23072747599043 839 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_530 4358-1714 28 µM -0.736540422515728 0.254351177685905 no 2511 0.230700938481575 847 1564641
SGTC_1238 0333-0287 48.8 µM -0.738308690159816 0.25383123152921 no 2512 0.230163443440873 840 7226
SGTC_51 1013-0126 23.419 µM -0.739442819728573 0.253498042957771 no 2513 0.229819074533552 837 1627850
SGTC_3315 9136395 68.55 µM -0.740259603942524 0.253258227643844 no 2514 0.22957124367628 872 16876844
SGTC_1711 st032263 62.8 µM -0.741095551935141 0.253012909244163 no 2515 0.229317753209031 859 3958979
SGTC_2485 5633444 17.78 µM -0.741457988388776 0.252906587033618 no 2516 0.229207897804375 837 5724239
SGTC_911 3456-4043 236 µM -0.742310733123802 0.252656523672377 no 2517 0.22894954515802 844 914281
SGTC_2982 9019404 25.97 µM -0.744488706546166 0.252018434794161 no 2518 0.228290435509227 819 22333232
SGTC_1267 0828-0272 9.49 µM -0.744522990319571 0.252008397353133 no 2519 0.228280068908692 851 745334
SGTC_1005 4092-0690 4.4 µM -0.745186538711586 0.251814168351495 no 2520 0.228079479729053 868 1529343
SGTC_1994 st072947 40.9 µM -0.747443902593562 0.251154001622879 no 2521 0.227397826439147 856 5286565 YDL195W SEC31
SGTC_370 0180-0345 38.7 µM -0.747731488633306 0.251069962790659 no 2522 0.227311066943903 838 3989527
SGTC_1531 st059297 52.4 µM -0.748659634901228 0.250798839986818 no 2523 0.227031189309312 862 7566702
SGTC_2226 7298446 200 µM -0.749968900937954 0.250416651182058 no 2524 0.226636717577771 856 3283010
SGTC_1717 st033143 58.0435 µM -0.750520642087243 0.250255684521219 no 2525 0.226470598169533 852 674616
SGTC_2380 9035439 200 µM -0.751263653664122 0.250039002758513 no 2526 0.226246999324989 863 6462575
SGTC_1155 4088-0394 48.2 µM -0.753780751537757 0.249305691095531 no 2527 0.225490441930347 861 2326248
SGTC_1892 st058411 7.36 µM -0.754179510543225 0.249189624764441 no 2528 0.225370719535919 861 3934738
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.754280611064089 0.249160202117966 no 2529 0.225340371091778 862 521171
SGTC_2296 7971656 126.45 µM -0.754467321832935 0.249105869718891 no 2530 0.225284330170871 846 666570
SGTC_2589 lobaric acid 100 µM -0.755233866288342 0.248882873135689 no 2531 0.22505433589039 873 73157 A novel microtubule depolymerizer.
SGTC_1231 0242-0792 125 µM -0.755712576513714 0.248743664752646 no 2532 0.224910771015129 856 3707635
SGTC_319 1348-1596 45.5 µM -0.756472175145064 0.248522859463225 no 2533 0.224683074471551 859 5380505
SGTC_2738 aclarubicin 5.55 µM -0.758975059906103 0.247796043521112 no 2534 0.223933738033684 823 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_280 3448-3607 3.04 µM -0.761944333539416 0.246935266214511 no 2535 0.223046614298863 828 626179
SGTC_2080 5212524 12.4 µM -0.762660063936866 0.24672801921911 no 2536 0.222833076749396 863 260183
SGTC_1950 st077106 7.18 µM -0.764513392374036 0.246191802287381 no 2537 0.222280679458005 843 13831864
SGTC_1266 0828-0227 32.9 µM -0.764807324040349 0.246106817534063 no 2538 0.222193142940746 879 3913820
SGTC_419 nsc-638432 893 µM -0.766419836950651 0.245640870161107 no 2539 0.221713266622841 855 368090
SGTC_345 1362-0200 395 µM -0.767271993272334 0.245394824848327 no 2540 0.221459908216599 865 1419823
SGTC_2218 6965428 192.983 µM -0.768112158612484 0.245152371445967 no 2541 0.221210277024018 852 675684
SGTC_1617 st002906 78 µM -0.769556071702223 0.244735990723488 no 2542 0.220781635649091 872 5150859
SGTC_2452 5863136 48.41 µM -0.770148370597013 0.244565299883768 no 2543 0.220605942915583 867 2184096
SGTC_245 methotrexate 289.6 µM -0.77022437873283 0.244543400227299 no 2544 0.220583402536525 836 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3126 9127922 49.47 µM -0.771402758148412 0.244204017740525 no 2545 0.220234120381895 877 45595682
SGTC_2215 7188065 200 µM -0.77231707279293 0.24394086303439 no 2546 0.219963328015815 864 940217
SGTC_922 1866-0035 480 µM -0.774460163604621 0.243324646526598 no 2547 0.219329358555738 863 3156169
SGTC_429 1112-0049 25.5 µM -0.776945538999166 0.242611065600772 no 2548 0.218595451129146 874 2836170
SGTC_56 0957-0365 83.25 µM -0.779941525330333 0.241752390642245 no 2549 0.21771264736759 871 6752360
SGTC_186 3455-3465 67.277 µM -0.780983840571618 0.24145404150183 no 2550 0.217405999474675 858 755278
SGTC_1634 st006576 41 µM -0.782060506726516 0.241146069967576 no 2551 0.21708950757549 850 3915356
SGTC_179 1273-0063 6.77 µM -0.783365047317576 0.240773203113537 no 2552 0.216706387668239 880 3108139
SGTC_2576 guaiol 23.12 µM -0.783721151738372 0.24067147504719 no 2553 0.216601874238747 843 227829
SGTC_2955 9076254 12.21 µM -0.783982056362525 0.24059695748273 no 2554 0.216525319600377 850 16459619
SGTC_2910 7948405 25.97 µM -0.786424016273318 0.239900113083878 no 2555 0.215809559034821 836 2971328
SGTC_1850 st056238 17 µM -0.786547759994174 0.2398648305639 no 2556 0.215773325172673 854 5393177
SGTC_1496 4469-0713 57.4 µM -0.787393345830132 0.239623808049492 no 2557 0.215525820412708 875 746691
SGTC_446 go6976 132 µM -0.787582647784799 0.239569868268022 no 2558 0.215470433896321 874 3501 A protein kinase C inhibitor.
SGTC_670 4204-0025 119 µM -0.788074192262937 0.239429838326407 no 2559 0.215326654941613 860 719039
SGTC_1418 3966-3099 2.4 µM -0.788496472845974 0.239309575810079 no 2560 0.215203180453217 852 740335
SGTC_1405 3909-7894 12 µM -0.790654428287929 0.238695520897648 no 2561 0.214572838033292 845 7104060
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.790990958661105 0.238599837592774 no 2562 0.214474633772256 883 6728940
SGTC_608 k048-0125 159 µM -0.791772140282422 0.238377810681597 no 2563 0.21424677483269 858 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3087 9117406 49.47 µM -0.792793709678444 0.238087631725212 no 2564 0.213949010994996 859 42546093
SGTC_3277 9138724 49.47 µM -0.793680899452393 0.237835780735222 no 2565 0.213690611283935 844 15943418
SGTC_1602 st001878 87.6 µM -0.793710124607673 0.237827486930905 no 2566 0.21368210236411 871 595405 YLR310C CDC25
SGTC_459 nigericin 15.3 µM -0.795465718155049 0.23732955824989 no 2567 0.21317132249166 883 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1363 1636-0063 10.4 µM -0.795872740286766 0.237214198756564 no 2568 0.213053003503724 849 6072185
SGTC_1414 3917-0015 5.4 µM -0.795875875915816 0.237213310166286 no 2569 0.213052092143171 858 6618702
SGTC_790 1575-0012 79.1 µM -0.796207750965621 0.237119272089813 no 2570 0.212955646581364 867 378741 YLR208W SEC13
SGTC_2308 7584454 197.62 µM -0.796340030458509 0.237081795894771 no 2571 0.212917212197715 874 893577
SGTC_2406 ethylparaben 405.7 µM -0.797158750865659 0.236849916075144 no 2572 0.21267941949356 886 8434 A possible steroid mimic.
SGTC_1695 st026914 34.495 µM -0.79954280591099 0.236175409464102 no 2573 0.21198786806857 873 3289191
SGTC_925 2064-1272 59.6 µM -0.800624692860426 0.235869666943949 no 2574 0.211674475562723 883 6815817
SGTC_1031 k035-0009 16 µM -0.800939045938278 0.235780871320772 no 2575 0.211583467102645 884 5180959
SGTC_1244 0416-0015 52.5 µM -0.80102393708813 0.235756895195303 no 2576 0.211558894167555 867 96201
SGTC_286 k060-0067 22.9 µM -0.80124126098691 0.23569552171908 no 2577 0.211495994328355 861 5985051
SGTC_1369 1866-0067 208 µM -0.801939441573605 0.235498411280096 no 2578 0.211293994731144 858 3531355
SGTC_3024 9090631 49.47 µM -0.802462407600326 0.235350827041094 no 2579 0.211142762773043 844 25236383
SGTC_349 k015-0014 24 µM -0.803044370462315 0.235186653566156 no 2580 0.210974544632179 880 2196908
SGTC_2024 5144227 134 µM -0.803907933716939 0.234943156364743 no 2581 0.210725073890384 864 3475211
SGTC_611 3453-1652 23.7 µM -0.803949792178625 0.234931357159028 no 2582 0.210712985994331 881 1560575
SGTC_1262 0737-0114 49.6 µM -0.804110562958321 0.234886041588459 no 2583 0.210666562353734 878 765919
SGTC_468 gf-109203x 121 µM -0.804264949602174 0.234842530026125 no 2584 0.210621987823582 870 2396 A protein kinase C inhibitor.
SGTC_106 0092-0003 11.579 µM -0.804616746650028 0.234743397943494 no 2585 0.210520437612499 868 1072148
SGTC_1361 1608-0041 5.61 µM -0.807358713727786 0.233971538740773 no 2586 0.209729923033037 866 X1361
SGTC_3262 9137218 49.47 µM -0.810503291535612 0.233088078730452 no 2587 0.20882548702069 822 17650664
SGTC_1909 st060837 51.5 µM -0.812078610613466 0.232646194725954 no 2588 0.208373262832853 865 678937
SGTC_3181 9108277 49.47 µM -0.812204755290227 0.232610830731544 no 2589 0.20833707568998 891 17097298
SGTC_2102 5377816 72.7585 µM -0.815328024859249 0.231736192195037 no 2590 0.207442285620445 866 1379702
SGTC_1923 st058458 19.1 µM -0.816027445283186 0.231540578335647 no 2591 0.207242219402292 900 3534982
SGTC_2298 7976326 193.81 µM -0.816515837063046 0.23140403955035 no 2592 0.207102584709001 871 2235818
SGTC_2829 7992743 58.44 µM -0.817134299505331 0.231231201597863 no 2593 0.206925841774133 883 16462845
SGTC_3168 9103419 49.47 µM -0.817232169770874 0.231203856989424 no 2594 0.206897880792427 864 16649256
SGTC_1510 1123-0200 71.5 µM -0.817787820237424 0.231048644403851 no 2595 0.206739176987024 885 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_19 0279-0214 38.434 µM -0.817804930750382 0.231043865763072 no 2596 0.206734291059798 882 3566274 YBR002C RER2
SGTC_3215 9129942 49.47 µM -0.818749129059895 0.230780254665337 no 2597 0.206464780108966 890 17682944
SGTC_1772 st048439 82.2 µM -0.818916160790529 0.230733638504448 no 2598 0.206417124429497 866 2927068 YDL195W SEC31
SGTC_1741 st038134 10.228 µM -0.822279410234152 0.229796123808163 no 2599 0.205458946173155 884 1272587
SGTC_1624 st003710 6.25 µM -0.825159376796296 0.228995023614601 no 2600 0.204640556579762 889 24207033
SGTC_1162 k048-0130 20.1 µM -0.825217830689799 0.228978780144045 no 2601 0.204623966056424 873 6797406
SGTC_612 0302-0167 22.4 µM -0.825987235831475 0.228765034128855 no 2602 0.204405666253564 899 235821
SGTC_828 2074-0507 139 µM -0.827832114230939 0.228252970860536 no 2603 0.203882792386627 872 X828
SGTC_720 r052-1644 49.9 µM -0.828717143337799 0.228007551613652 no 2604 0.2036322413698 877 1422863 YOR257W CDC31
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.831918384990623 0.227121085342914 no 2605 0.202727506834532 877 688664
SGTC_1404 3909-7820 48.3 µM -0.832207869886041 0.227041019038815 no 2606 0.202645811241248 852 23741373
SGTC_1 0258-0098 57.368 µM -0.832397648243953 0.226988538403484 no 2607 0.202592264530082 839 6790032 YDR047W HEM12
SGTC_845 0330-0138 4.51 µM -0.834415048164894 0.226431076829727 no 2608 0.202023570169564 879 9039800
SGTC_1643 st009866 20.2 µM -0.836180565697461 0.225943852105866 no 2609 0.201526664921394 852 3156273 YOR207C RET1
SGTC_874 0599-0792 117 µM -0.836557102952396 0.225840016960863 no 2610 0.20142078326254 874 765305
SGTC_2914 7968218 45.32 µM -0.836903103286926 0.225744626574221 no 2611 0.201323517935513 855 2977111
SGTC_1143 3454-2408 5.08 µM -0.837207620404131 0.225660691742057 no 2612 0.201237937395077 843 X1143
SGTC_1392 3455-1037 33.9 µM -0.839402296391208 0.225056290048415 no 2613 0.200621797829091 851 981132
SGTC_3014 9081533 49.47 µM -0.839892212196169 0.224921495277486 no 2614 0.2004844122721 893 21367265
SGTC_1151 3909-8316 15.3 µM -0.842289729362066 0.224262505996105 no 2615 0.199812899287282 890 800431
SGTC_3296 9122258 64.045 µM -0.842346492686936 0.224246917141662 no 2616 0.199797017039482 892 4730474
SGTC_1251 0490-5699 265 µM -0.84323740943521 0.224002326201364 no 2617 0.199547840084248 872 3883818
SGTC_680 0417-1641 114 µM -0.844426410759996 0.223676135811717 no 2618 0.199215584563243 884 2835990
SGTC_2820 7989630 71.43 µM -0.845333785139572 0.223427388706671 no 2619 0.198962251418831 825 2984098
SGTC_1247 0448-0043 5.84 µM -0.845817903529261 0.223294737174547 no 2620 0.198827168109623 909 3089013 YGL099W LSG1
SGTC_961 1252-1571 372 µM -0.846629315719052 0.223072505601478 no 2621 0.19860088420318 899 6813498
SGTC_2393 9031399 185.94 µM -0.8467372454054 0.223042955045988 no 2622 0.198570796843462 902 1526623 YDL150W RPC53
SGTC_1128 3448-9350 235 µM -0.850296716668063 0.222069641252445 no 2623 0.197580070775296 872 619386
SGTC_297 0986-0032 24 µM -0.852054866590161 0.221589782798042 no 2624 0.197091820237266 883 2847425
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.853497107419099 0.221196589438864 no 2625 0.196691845529146 884 551469
SGTC_1322 1348-1070 12 µM -0.853505538326582 0.221194292122401 no 2626 0.196689508843282 872 6758089
SGTC_1084 voriconazole 435 nM -0.8552997482944 0.220705703060898 no 2627 0.196192613430537 891 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1450 4112-4260 37.6 µM -0.855899370477089 0.220542555269344 no 2628 0.196026721605235 879 1633175
SGTC_3081 9117243 49.47 µM -0.856304172364632 0.220432454107905 no 2629 0.195914777003191 889 45595589
SGTC_2754 granisetron 64.02 µM -0.858437788764608 0.219852657419562 no 2630 0.195325384366842 900 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1760 st045453 10.4495 µM -0.858968194515528 0.219708658989693 no 2631 0.19517903183232 887 3323419 YIL048W NEO1
SGTC_2746 daunorubicin 9.88 µM -0.859915002214506 0.219451747369811 no 2632 0.194917949048683 845 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_335 4077-0256 27.6 µM -0.861744947760812 0.218955690092599 no 2633 0.194413942734054 884 3121989
SGTC_471 1-acyl-paf 4 µM -0.862926551041226 0.218635726876619 no 2634 0.194088925734594 871 16759367
SGTC_2757 clomiphene 4.22 µM -0.863295621453165 0.218535842471056 no 2635 0.193987475484055 899 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2941 9056145 11.23 µM -0.864750622600723 0.218142320223026 no 2636 0.193587838963634 880 2119517
SGTC_953 1188-0045 9.7 µM -0.86534949085371 0.217980467947215 no 2637 0.193423497346652 895 6144426
SGTC_1714 st033236 13.627 µM -0.86552142821353 0.21793401233748 no 2638 0.193376329972755 906 2916566
SGTC_155 k072-0202 43.6 µM -0.866129940511285 0.217769644778229 no 2639 0.193209453888381 888 5857737
SGTC_2664 lyso-paf C-16 73.48 µM -0.866356895691719 0.21770835936996 no 2640 0.193147237080182 892 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2204 7233102 200 µM -0.866523063564201 0.217663494856666 no 2641 0.193101692077607 872 2172480
SGTC_1020 4335-0961 93.3 µM -0.866718206240303 0.217610814099789 no 2642 0.193048213734655 908 669075
SGTC_1230 0170-0365 3.77 µM -0.868959263347733 0.217006345536369 no 2643 0.192434706328027 865 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3071 9117417 49.47 µM -0.869329914951533 0.216906465225901 no 2644 0.192333352478462 901 45595590 YGL055W OLE1
SGTC_2362 9071156 126 µM -0.870264423052885 0.216654759248836 no 2645 0.192077958288036 914 653133
SGTC_779 1360-0071 233 µM -0.870408978320765 0.216615838965813 no 2646 0.19203847093709 863 7566
SGTC_737 1950-0117 57.9 µM -0.871000542983542 0.216456607332353 no 2647 0.191876928307104 896 5393513
SGTC_2933 9026794 32.47 µM -0.873296786835369 0.215839168808891 no 2648 0.191250665735635 893 17586027
SGTC_1327 1436-0082 2.18 µM -0.873531853356963 0.215776019261587 no 2649 0.191186626002326 909 15992205
SGTC_2002 4023503 131 µM -0.874135750435511 0.215613834175544 no 2650 0.191022165161826 903 4736863 YCR052W RSC6
SGTC_399 oxolinic acid 75 µM -0.874202638971454 0.215595874664207 no 2651 0.191003954574109 870 4628 A DNA gyrase inhibitor.
SGTC_2286 7945697 125 µM -0.878538834260526 0.214433462277103 no 2652 0.189825686350738 902 1245733
SGTC_1578 josamycin 24.2 µM -0.878551841754428 0.214429980824122 no 2653 0.189822158579985 880 5282165 A P450 substrate.
SGTC_941 3237-0776 460 µM -0.879557743622828 0.21416085096909 no 2654 0.189549469405233 894 760008
SGTC_649 1123-0311 367 µM -0.879709397248267 0.214120292975958 no 2655 0.189508378656771 887 693629 YIL048W NEO1
SGTC_2063 5246145 200 µM -0.880805132201588 0.213827384288463 no 2656 0.189211650733157 908 711240
SGTC_1876 myriocin 605 nM -0.880941927776332 0.213790832882938 no 2657 0.189174626226518 899 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3336 9143619 71.43 µM -0.881144864328699 0.213736615491679 no 2658 0.189119708503843 908 45595730
SGTC_2278 7948257 134.34 µM -0.881782796018611 0.213566235116293 no 2659 0.188947138421301 893 1247028
SGTC_1968 st069590 43.6 µM -0.883481793249221 0.213112848977459 no 2660 0.188488007662013 889 6384066
SGTC_184 1494-0393 24.714 µM -0.885529324018288 0.212567201592703 no 2661 0.187935605557997 898 3090647
SGTC_220 paclitaxel 373.376 µM -0.886377631206941 0.212341375112473 no 2662 0.18770703441745 885 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1702 st027038 51 µM -0.889148404724634 0.211604749496999 no 2663 0.186961663761479 897 5521182
SGTC_856 0433-0016 11.3 µM -0.889301201143115 0.211564171284291 no 2664 0.186920613076233 892 3911780
SGTC_655 k060-0012 42 µM -0.891115198851165 0.211082775303816 no 2665 0.186433685944106 916 5994525
SGTC_1961 st076550 68.7 µM -0.891809869916033 0.210898594683358 no 2666 0.186247425266856 905 1579337
SGTC_708 3448-5400 146 µM -0.892304434173389 0.210767526540586 no 2667 0.186114889099391 910 3462195
SGTC_1523 st012844 44.7 µM -0.895291138844082 0.209977013878662 no 2668 0.185315737957066 915 4274103
SGTC_2355 9061122 103.12 µM -0.895363168014012 0.209957970939716 no 2669 0.185296491494409 921 5302957
SGTC_2112 5488546 200 µM -0.897359372172605 0.209430622102509 no 2670 0.184763592231353 919 600757
SGTC_2704 st078022 71.1 µM -0.897699162169559 0.20934093548978 no 2671 0.1846729781301 913 54697681
SGTC_3209 9113616 49.47 µM -0.898133667040071 0.209226282091194 no 2672 0.184557146036266 902 16649353
SGTC_1703 st026983 48.3 µM -0.898145034484833 0.209223283044159 no 2673 0.184554116262756 885 1104023
SGTC_2739 tacrine 100.86 µM -0.89825715582504 0.209193703682384 no 2674 0.184524234135753 864 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3199 9111318 49.47 µM -0.89873421906482 0.209067874469839 no 2675 0.184397122811039 870 8548020
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.899778501514773 0.20879259230646 no 2676 0.184119068701015 878 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1075 aripiprazole 15.2 µM -0.900235565348824 0.208672173436469 no 2677 0.183997451526566 909 60795 An atypical antipschotic. YIL048W NEO1
SGTC_375 3970-0961 9.27 µM -0.900486223739804 0.208606151904658 no 2678 0.183930776690183 879 2898222
SGTC_74 000s-0487 160.283 µM -0.902251900035648 0.208141435069304 no 2679 0.183461535258361 895 677548
SGTC_1677 st019204 53.9 µM -0.9037068999515 0.20775894621636 no 2680 0.183075419709567 906 3945625
SGTC_1851 st056236 18.9 µM -0.907531057994549 0.206755637229801 no 2681 0.182063016608014 856 5393171
SGTC_2707 st078556 66.6 µM -0.90988077832633 0.206140588177308 no 2682 0.181442693926837 882 17250899
SGTC_176 1486-1328 72.834 µM -0.90999318435035 0.206111192647266 no 2683 0.181413052102683 898 22310231
SGTC_984 1492-0255 2.91 µM -0.910391168142094 0.206007135069417 no 2684 0.181308126888868 912 1585198
SGTC_2584 androsterone 48.74 µM -0.910782312686573 0.205904896058456 no 2685 0.181205041822912 849 2754130 A steroid.
SGTC_2697 mebhydrolin 72.4 µM -0.911441415532724 0.20573268508535 no 2686 0.181031420150494 915 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2245 6637752 200 µM -0.912465530770274 0.205465273004412 no 2687 0.180761853350299 919 681890
SGTC_2767 sibutramine 71.45 µM -0.913836754226611 0.205107549056326 no 2688 0.180401315262667 910 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1948 st076329 66.6 µM -0.914207740662291 0.205010829993735 no 2689 0.180303848772155 894 24208413
SGTC_1809 st050081 57.6 µM -0.917152863693173 0.204243975791113 no 2690 0.179531271469504 894 5036894
SGTC_35 0133-0054 64.071 µM -0.917574331571983 0.204134373428129 no 2691 0.17942088064178 909 99677
SGTC_1064 honokiol 6.76 µM -0.917674726855429 0.204108270887357 no 2692 0.179394591412902 911 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1491 4138-0063 26.5 µM -0.917929702918654 0.204041986639779 no 2693 0.179327834978739 911 23883227
SGTC_2347 9049783 174.81 µM -0.920668751119077 0.203330745632791 no 2694 0.178611697863108 932 6467988 YPL169C MEX67
SGTC_2860 9025725 38.96 µM -0.92103189804158 0.203236559483263 no 2695 0.178516886780897 921 40546248
SGTC_115 0527-0192 112.043 µM -0.921358594067774 0.203151849529059 no 2696 0.178431619459377 923 4233931
SGTC_2524 avocatin b 10.57 µM -0.921489163183733 0.203117999782841 no 2697 0.178397548234071 879 6710748
SGTC_2595 hexamethylquercetagetin 100 µM -0.922211118877518 0.202930895202724 no 2698 0.178209232235862 932 386331
SGTC_2302 7771753 200 µM -0.927220341970492 0.2016355247175 no 2699 0.176906071620895 899 2203047
SGTC_3260 9137109 49.47 µM -0.930205748952748 0.200865868376506 no 2700 0.176132282939911 886 17478346
SGTC_439 amiodarone 34.4 µM -0.931535471040712 0.200523626055605 no 2701 0.175788322498918 902 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_803 4488-1585 147 µM -0.933018991653185 0.200142212819425 no 2702 0.175405081369856 899 747204
SGTC_2357 9067248 200 µM -0.933630332027279 0.199985164127191 no 2703 0.175247306698619 948 9150235
SGTC_1622 st003707 19.4 µM -0.937498787171661 0.1989931064272 no 2704 0.17425102366724 890 10140899
SGTC_1529 apigenin 74 µM -0.93827474593529 0.198794471006612 no 2705 0.174051617248066 907 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_361 000s-0510 1.45 µM -0.940600240482822 0.19819989077015 no 2706 0.173454879315838 912 660
SGTC_989 1501-0895 10.3 µM -0.941471357776792 0.197977441006288 no 2707 0.17323168028035 898 2830112
SGTC_1186 1319-0216 26 µM -0.942921369778578 0.197607498425256 no 2708 0.172860561722136 922 4565136
SGTC_1972 st070201 17.4 µM -0.943747781139258 0.19739684258169 no 2709 0.172649275425909 915 2829099
SGTC_111 0083-0039 52.457 µM -0.945267293471156 0.197009866885569 no 2710 0.172261215824197 875 759313
SGTC_1560 lithocholic acid 53.1 µM -0.946750687526546 0.196632532743611 no 2711 0.171882917548355 886 9903 A bile acid which acts as a detergent.
SGTC_3299 9121982 43.1275 µM -0.947525668697652 0.196435573344089 no 2712 0.171685491350311 917 17594604 YPL160W CDC60
SGTC_2055 5235184 200 µM -0.949725814818025 0.195877063971839 no 2713 0.171125794609303 903 2836034
SGTC_257 daunorubicin 18.5 µM -0.950768350090525 0.195612752124416 no 2714 0.17086099125503 892 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2831 7999036 19.48 µM -0.950844346852986 0.195593493291528 no 2715 0.170841698380145 945 2988270
SGTC_2172 5754775 163.918 µM -0.951610337938783 0.195399442807169 no 2716 0.170647318329166 898 2263357
SGTC_684 1140-0066 328 µM -0.951967911893223 0.195308897732715 no 2717 0.170556627847964 908 6813534
SGTC_810 3825-7150 143 µM -0.954594225559956 0.194644642648217 no 2718 0.169891469229056 881 22330411 YGL099W LSG1
SGTC_1351 1496-0003 46.5 µM -0.955238311260257 0.194481948707225 no 2719 0.16972859786402 924 3891978
SGTC_3111 9122088 49.47 µM -0.957558223902219 0.193896632682368 no 2720 0.169142786733843 891 16876704
SGTC_3319 9138450 16.7555 µM -0.959683368692027 0.193361400044812 no 2721 0.168607298053375 896 2029690
SGTC_3027 9089541 49.47 µM -0.960845982118284 0.193068969572602 no 2722 0.16831480730325 929 9943819
SGTC_3240 9133527 49.47 µM -0.961093125677815 0.19300684073046 no 2723 0.168252672914155 918 17617455
SGTC_2819 7996655 46.38 µM -0.96162688891534 0.192872700900181 no 2724 0.168118529792865 893 6456960
SGTC_216 k038-0035 28.382 µM -0.962061968108648 0.192763403456294 no 2725 0.168009238450526 919 4444231 YPR107C YTH1
SGTC_2834 9001755 58.44 µM -0.962231809210828 0.192720747476209 no 2726 0.167966586992639 930 2989575
SGTC_715 0868-0130 184 µM -0.963998183987569 0.192277460418726 no 2727 0.167523418170609 959 2876258
SGTC_527 4476-4215 268 µM -0.96454496772917 0.19214036680247 no 2728 0.167386387468925 882 4418754
SGTC_3166 9102297 49.47 µM -0.965715420887889 0.191847103321472 no 2729 0.167093300442085 923 25237072
SGTC_1552 6-methylflavone 10.6 µM -0.966142632030126 0.191740131517341 no 2730 0.166986407221949 912 689013
SGTC_2404 5161160 200 µM -0.968123352080344 0.191244645269367 no 2731 0.166491384302521 912 2831543
SGTC_2125 5246583 200 µM -0.96813502997409 0.19124172631984 no 2732 0.166488468567227 910 835267
SGTC_134 0269-0018 6.916 µM -0.971531727167075 0.190393863994871 no 2733 0.165641780902597 928 4378915
SGTC_2809 7964133 12.99 µM -0.972307100987953 0.190200644150907 no 2734 0.165448896115181 947 1253665
SGTC_38 0929-0051 58.268 µM -0.972375718419276 0.190183550784699 no 2735 0.165431833596605 925 1379719
SGTC_1091 telmisartan 47.6 µM -0.972397414151432 0.190178146332638 no 2736 0.165426438938544 947 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_687 k029-0044 34.9 µM -0.973169794075906 0.189985806367317 no 2737 0.165234460310347 916 5829338
SGTC_491 tetrandrine 80.3 µM -0.975976918170017 0.189287776909377 no 2738 0.164537951375555 924 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1125 tnp00248 1.32998 µM -0.979292991566268 0.188465227441685 no 2739 0.163717616169974 920 24207736
SGTC_1525 8-methoxypsoralen 92.5 µM -0.979766729252641 0.188347897387515 no 2740 0.163600639342788 951 4114 Related to psoralen; DNA damaging agent.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.980346098723155 0.188204466898771 no 2741 0.163457653364527 942 689007
SGTC_3343 9148379 18.9835 µM -0.982502521066597 0.187671208870914 no 2742 0.162926170782116 893 1955036
SGTC_937 3122-0005 46.7 µM -0.983494532816749 0.187426209742056 no 2743 0.162682052379174 902 759535
SGTC_2594 a-mangostin 100 µM -0.983561441480618 0.187409692294956 no 2744 0.162665595784654 942 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_475 α-linolenic acid 10 µM -0.983889786797776 0.187328648175514 no 2745 0.16258485294578 912 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_93 0109-0045 59.227 µM -0.984641873688562 0.18714309534147 no 2746 0.162400006821689 932 88733
SGTC_1792 st045773 43.6 µM -0.984643818903482 0.187142615570759 no 2747 0.162399528908813 862 2919270
SGTC_1805 st050013 60.3 µM -0.988544156117098 0.186182160938427 no 2748 0.161443110106145 909 4037144
SGTC_2873 9040596 71.43 µM -0.990019156658082 0.185819740852699 no 2749 0.161082377852835 927 6463863
SGTC_1120 ficusin 1.78878 µM -0.990806816006045 0.185626385643419 no 2750 0.160889960212183 946 6199 A DNA cross-linker.
SGTC_598 3937-0236 20.2 µM -0.991330266200946 0.185497957771138 no 2751 0.160762169364231 947 1379313
SGTC_1058 3448-5425 97.3 µM -0.991958486983608 0.185343897391314 no 2752 0.160608888208968 902 7279705
SGTC_2644 guaiazulene 100 µM -0.992864274923143 0.18512190831184 no 2753 0.160388050847844 907 3515 A coloring agent.
SGTC_142 0335-0849 62.6745 µM -0.993296690998096 0.185015990727433 no 2754 0.160282694825359 894 3889043 YPR107C YTH1
SGTC_1507 4075-3230 155 µM -0.996997205485025 0.184111113555806 no 2755 0.159382933191965 913 659771
SGTC_41 0478-0632 82.643 µM -0.997573318612981 0.183970486354453 no 2756 0.159243152240642 909 3750424
SGTC_2208 7283366 200 µM -0.998101586314617 0.183841596854028 no 2757 0.159115050494247 903 898663
SGTC_1417 3966-0327 90.4 µM -0.998766555370926 0.18367943422581 no 2758 0.158953895487356 948 651118
SGTC_570 0987-0065 62.6 µM -0.999714903580996 0.183448319601966 no 2759 0.158724248752207 880 3104428
SGTC_1616 st002734 56.1 µM -1.00067304260237 0.183215003115169 no 2760 0.158492452130041 930 4026101
SGTC_2636 apigenin dimethyl ether 100 µM -1.0016579118274 0.182975370534953 no 2761 0.158254420354273 941 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2536 dehydroabietamide 32.04 µM -1.00179506608596 0.182942014489665 no 2762 0.158221290336435 934 3983547
SGTC_2627 acetyl isogambogic acid 100 µM -1.00297201884278 0.182655934482108 no 2763 0.157937181028334 947 6857789 A caspase activator and apoptosis inducer.
SGTC_3076 9116187 49.47 µM -1.00357676149418 0.182509049362199 no 2764 0.157791330150673 917 27241210
SGTC_1748 st037455 53.6035 µM -1.00424299518348 0.182347314206836 no 2765 0.157630751406709 937 580690
SGTC_694 1315-0438 43.2 µM -1.00811238975694 0.181409749800781 no 2766 0.156700255168852 921 6793154
SGTC_2430 5571206 200 µM -1.00820373817648 0.181387652367985 no 2767 0.156678331844535 927 1731771
SGTC_322 k048-0136 19.3 µM -1.00856806075057 0.181299538504357 no 2768 0.156590915692322 943 6823282
SGTC_1828 st055811 49 µM -1.01022857569323 0.180898271381367 no 2769 0.156192895783492 938 5877589
SGTC_2876 9059903 25.97 µM -1.01456007261406 0.179854177777748 no 2770 0.155157790086734 903 6916095
SGTC_1098 clofazimine 15.1 µM -1.01488486033705 0.179776041572374 no 2771 0.155080357908486 946 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_333 3486-0131 40.1 µM -1.015087965711 0.179727190086756 no 2772 0.155031948814643 906 6744690
SGTC_2808 7946468 45.46 µM -1.0162588905393 0.179445718561931 no 2773 0.154753059667894 941 2970879
SGTC_784 4579-0127 173 µM -1.01665523509509 0.179350506505185 no 2774 0.154658734041178 939 1948547
SGTC_272 doxorubicin 8.13 µM -1.01691766941697 0.179287480579982 no 2775 0.154596298482072 944 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3186 9110464 49.47 µM -1.01773752664704 0.179090674345751 no 2776 0.154401354165383 931 17018021
SGTC_1192 1488-0095 21.4 µM -1.01831042264149 0.178953231707111 no 2777 0.154265228393656 960 915875
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.01963489384703 0.178635733961579 no 2778 0.153950824828805 935 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2223 6903751 107.57 µM -1.02458328949655 0.177452662305834 no 2779 0.152779926299765 922 5598863
SGTC_1449 4112-4002 201 µM -1.02507563262495 0.17733522313914 no 2780 0.15266375107101 930 2059539
SGTC_2921 7974240 10.71 µM -1.02539706631136 0.177258577680834 no 2781 0.152587935936217 931 2979074 YDR527W RBA50
SGTC_2799 7812892 81.82 µM -1.0255259648069 0.177227847874249 no 2782 0.152557540239433 937 20205235
SGTC_1718 roemerine 11.9335 µM -1.02686976164397 0.176907682884928 no 2783 0.152240897291992 880 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1699 st031318 29.054 µM -1.02721968907527 0.176824371292303 no 2784 0.152158514479656 932 5340658
SGTC_1941 st076221 61.8 µM -1.03621382457781 0.174691540365047 no 2785 0.150051199311836 887 2828568
SGTC_933 2914-0560 114 µM -1.03850644775731 0.174150500612242 no 2786 0.149517167509773 925 463887
SGTC_1490 4089-0339 670 nM -1.03911620150089 0.174006783355892 no 2787 0.149375348429803 928 742542
SGTC_864 0469-0573 172 µM -1.04477903518339 0.172675673002391 no 2788 0.148062553263112 971 689425
SGTC_2014 4013930 200 µM -1.04525385304096 0.172564357666825 no 2789 0.147952829818937 955 64556
SGTC_2077 5212015 200 µM -1.04728427131707 0.172088866874292 no 2790 0.147484244073577 929 780900
SGTC_967 1306-0166 352 µM -1.04734525662049 0.172074598060725 no 2791 0.147470185108626 924 4437607
SGTC_2716 st080858 38.6235 µM -1.04902960427307 0.171680807451936 no 2792 0.147082246674612 931 5296050
SGTC_2156 5649887 115 µM -1.05011300446309 0.171427819319203 no 2793 0.146833080209196 962 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3144 9087057 49.47 µM -1.05024006107512 0.171398165554636 no 2794 0.146803877577173 934 17249618
SGTC_662 k832-1615 104 µM -1.05085408418985 0.171254904806916 no 2795 0.146662805708686 949 5878478
SGTC_1686 st019653 115.5 µM -1.05280587203852 0.170800032236757 no 2796 0.146214986584952 962 97252
SGTC_2442 5158906 48.48 µM -1.05307549617194 0.170737256008601 no 2797 0.146153196166223 922 1893835
SGTC_2 0422-0095 29 µM -1.05852137430502 0.169472461809164 no 2798 0.144908905704375 924 6790840
SGTC_2285 7945142 200 µM -1.05876064524142 0.169417029845195 no 2799 0.144854400422708 925 2970608
SGTC_2212 7123476 200 µM -1.05984070821279 0.169166956185135 no 2800 0.144608536767265 930 1085715
SGTC_3330 9141424 71.43 µM -1.06099515056954 0.16889992320325 no 2801 0.144346052517437 925 27261020
SGTC_359 0081-0058 15.9 µM -1.06238257239187 0.168579358448771 no 2802 0.144031021104499 925 3494159
SGTC_2056 5235370 200 µM -1.06310687098971 0.168412164257071 no 2803 0.143866744432101 963 5511916
SGTC_2743 auranofin 4.32 µM -1.06363535607164 0.168290238185839 no 2804 0.143746959610062 924 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2840 9008771 71.43 µM -1.06736869648167 0.167430542125469 no 2805 0.142902689123026 911 2992978
SGTC_3207 9114163 49.47 µM -1.06914997367514 0.167021356938615 no 2806 0.142501048228424 972 849233
SGTC_2702 st077768 96.8 µM -1.06956241603918 0.166926704972897 no 2807 0.142408160029809 914 6484119
SGTC_862 0452-0056 10.2 µM -1.07064104409589 0.166679332723436 no 2808 0.142165430491551 952 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1307 1187-1599 12.2 µM -1.07090019850868 0.166619933589386 no 2809 0.142107153306606 936 1538471
SGTC_852 0418-0143 439 µM -1.07195133167578 0.166379150145274 no 2810 0.141870946208031 916 5369229
SGTC_3 0833-0587 95.581 µM -1.07629592693222 0.165386317048648 no 2811 0.140897464841447 942 5382644
SGTC_940 3232-1287 54.8 µM -1.08407207170992 0.163618892216593 no 2812 0.139166422327275 953 1585493 YIL048W NEO1
SGTC_2954 9074818 52.69 µM -1.08619041779404 0.163139550730021 no 2813 0.138697377893723 965 16648742
SGTC_2141 5621638 7.665 µM -1.08625399234766 0.163125179135995 no 2814 0.138683317872196 954 2856238
SGTC_3064 1327-0027 10 µM -1.08653112246489 0.163062541016363 no 2815 0.138622039668855 913 16000455 YPR107C YTH1
SGTC_2221 6807166 181.081 µM -1.08729558465047 0.162889835100205 no 2816 0.138453099653474 927 674925
SGTC_2225 6654152 15.4 µM -1.08842549267157 0.162634786216966 no 2817 0.138203656084812 918 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2346 9031566 143.75 µM -1.08939717426407 0.16241566093606 no 2818 0.137989388485249 951 4771086
SGTC_558 k064-0027 21.3 µM -1.08998751765092 0.162282625646424 no 2819 0.137859321297693 923 5088526
SGTC_3040 9091894 49.47 µM -1.09162597530367 0.161913767087404 no 2820 0.137498767047411 915 25236966
SGTC_1476 4112-3294 3.34 µM -1.09181421838912 0.16187142378174 no 2821 0.137457384086766 918 704369
SGTC_817 1391-0715 46 µM -1.09691840281496 0.160726041461882 no 2822 0.13633853165065 955 1353946
SGTC_213 1246-0773 967 nM -1.09923406019477 0.160208155880556 no 2823 0.135832992897139 950 6251622
SGTC_3316 9136639 10.545 µM -1.09953916208671 0.160140002735225 no 2824 0.135766480935885 931 4903665
SGTC_1229 0139-0193 12.2 µM -1.09963251584258 0.160119153318524 no 2825 0.135746134351349 948 3090752
SGTC_2970 9090938 41.86 µM -1.10070357165738 0.159880073126733 no 2826 0.135512845638287 956 17217104
SGTC_2549 cedrol 20.94 µM -1.10072566343267 0.159875144278004 no 2827 0.135508036679882 935 6708665 A sedative which affects the nervous system.
SGTC_1808 st050063 61.5 µM -1.10078058500018 0.159862891275258 no 2828 0.135496081808185 961 4011993
SGTC_2075 5212009 200 µM -1.10086438459675 0.159844196767392 no 2829 0.135477842399079 944 780898
SGTC_2443 5493264 126.67 µM -1.10087987363173 0.159840741538784 no 2830 0.135474471315946 965 5340055
SGTC_661 1304-0007 33.6 µM -1.10096087660686 0.159822672532557 no 2831 0.135456842505608 955 3117130
SGTC_383 2324-0395 7.37 µM -1.10607866118776 0.158683778269505 no 2832 0.134346236951701 896 3146421
SGTC_3058 9093861 49.47 µM -1.10651647043908 0.158586597373873 no 2833 0.134251519560098 940 17217477
SGTC_2012 4023501 200 µM -1.10899432034834 0.158037322569738 no 2834 0.133716316081758 966 3477460
SGTC_3270 9137563 49.47 µM -1.10928145704198 0.157973752686145 no 2835 0.133654390929981 908 17015724
SGTC_859 0439-0102 54.6 µM -1.11088622053931 0.157618779388344 no 2836 0.133308663704607 952 610143
SGTC_1410 3909-8106 77.9 µM -1.11530964438252 0.156643034318939 no 2837 0.132358876980568 956 1039210
SGTC_507 nimesulide 162 µM -1.11642984709655 0.156396565681063 no 2838 0.132119091719453 959 4495 A COX2 inhibitor.
SGTC_247 mechlorethamine 29.705 µM -1.116501082984 0.156380900898861 no 2839 0.132103853440288 936 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3345 9148410 3.559 µM -1.11767595549601 0.156122695324648 no 2840 0.131852707797397 923 4903596
SGTC_2827 7993847 71.43 µM -1.11769394148957 0.156118744668511 no 2841 0.131848865597993 935 2985692
SGTC_875 0709-0210 25.7 µM -1.11935468401764 0.155754243415338 no 2842 0.131494427659136 967 6251364
SGTC_2525 harmine 47.85 µM -1.11968526742869 0.155681753697888 no 2843 0.131423952662749 930 5280953 A monoamine oxidase inhibitor
SGTC_3291 9121177 71.43 µM -1.12001479485026 0.155609517682779 no 2844 0.131353728742726 962 17015612
SGTC_918 glabranin 770.725 nM -1.1200282408721 0.155606570637247 no 2845 0.131350863879371 960 124049 Also referred to as licorice root.
SGTC_2856 9022925 19.48 µM -1.12052495324223 0.155497728996961 no 2846 0.131245062583367 958 4944862
SGTC_1304 1165-0502 251 µM -1.12176473153705 0.155226282905591 no 2847 0.130981242741624 955 767425
SGTC_869 0564-0080 44.1 µM -1.12470321991644 0.154584158814549 no 2848 0.130357408402932 946 6843321
SGTC_352 k048-0007 5.11 µM -1.12591400264733 0.154320087697508 no 2849 0.130100960878072 966 6811911
SGTC_2650 prasterone 100 µM -1.12791521613024 0.153884278349462 no 2850 0.129677863542455 940 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_564 3555-0129 330 µM -1.12987627100763 0.153458005365016 no 2851 0.129264181973387 917 563260
SGTC_1103 duloxetine 36.1 µM -1.13128580873912 0.153152098800503 no 2852 0.128967407700592 978 60835 A selective serotonin reuptake inhibitor.
SGTC_1732 st034308 51.822 µM -1.13284035985503 0.152815189500286 no 2853 0.128640649583784 933 830119
SGTC_3084 9116877 49.47 µM -1.13368875878568 0.152631528147174 no 2854 0.128462563302906 947 27241325
SGTC_2200 6600604 21.907 µM -1.13415183558387 0.152531343111288 no 2855 0.128365431702881 986 2904777
SGTC_2641 levomentholum 100 µM -1.1364705065428 0.152030363152967 no 2856 0.127879851125431 956 16666
SGTC_2532 xanthone 78.9 µM -1.13654312599277 0.152014690417011 no 2857 0.127864663660879 975 7020 An insecticide.
SGTC_3164 9100705 49.47 µM -1.13942188700751 0.151394260432057 no 2858 0.12726361568779 933 17174235
SGTC_1521 st012942 49.4 µM -1.13995596864921 0.151279340710464 no 2859 0.127152322866375 951 24207259
SGTC_2504 purpurogallin 52.29 µM -1.14139258352028 0.150970508603506 no 2860 0.126853294801396 953 5281571 An antioxidant.
SGTC_3032 9089427 49.47 µM -1.14379072009436 0.150455911624703 no 2861 0.1263552196431 913 17173707
SGTC_2717 st081029 62.2815 µM -1.14600284654279 0.149982266357413 no 2862 0.12589698712639 947 5292846
SGTC_2483 5729050 27.16 µM -1.14662863152547 0.149848458198776 no 2863 0.125767569004329 967 2865180
SGTC_1370 2001-0092 44.6 µM -1.14689653188493 0.149791198886224 no 2864 0.125712193110112 961 790957
SGTC_699 0375-0592 111 µM -1.147157531094 0.149735428618869 no 2865 0.125658260066767 928 762578
SGTC_1008 4106-0037 6 µM -1.14863204700471 0.149420614520124 no 2866 0.125353868387428 958 2905394
SGTC_1215 3852-0577 11.2 µM -1.14991260066724 0.149147570731223 no 2867 0.125089935234153 956 2884876
SGTC_900 1112-0045 141 µM -1.15271131588998 0.148551980294724 no 2868 0.124514447622191 939 56211 YIL048W NEO1
SGTC_3219 9131112 49.47 µM -1.15335997539004 0.148414167339301 no 2869 0.124381331240177 933 17612988 YMR079W SEC14
SGTC_3090 9117696 49.47 µM -1.15418697519217 0.148238588584049 no 2870 0.12421176064754 933 7923821
SGTC_2255 7941087 197.44 µM -1.15575336613568 0.14790641212088 no 2871 0.123891026383175 994 935561
SGTC_1903 st060211 78.3 µM -1.15666887230456 0.147712496349274 no 2872 0.123703835941221 948 688960
SGTC_344 k064-0035 6.43 µM -1.15853448473765 0.147317863278764 no 2873 0.123322993650781 937 5088750
SGTC_2763 lisinopril 49.32 µM -1.16031496041942 0.146941898741751 no 2874 0.122960297833829 955 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_290 2043-6722 48.1 µM -1.1653254322945 0.145887345577676 no 2875 0.121943644154 964 773758 YLR208W SEC13
SGTC_2794 7785382 27.27 µM -1.16629642810698 0.145683570042707 no 2876 0.121747308429482 951 2205081
SGTC_588 3970-1144 52.9 µM -1.16832666344823 0.145258118525808 no 2877 0.12133751204891 945 1888707
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.16856609060771 0.145207999875805 no 2878 0.121289248469126 957 688788
SGTC_2289 7946404 165.07 µM -1.16864896945459 0.145190653778767 no 2879 0.12127254494784 952 1246120 YPR165W RHO1
SGTC_1573 oleylamine 1.06 µM -1.16999473209156 0.144909188034024 no 2880 0.121001544398805 964 5356789 An amine of the fatty acid oleic acid.
SGTC_410 α-linolenic acid 100 µM -1.17007154312046 0.144893134126419 no 2881 0.120986089578776 966 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1799 st045822 46.1415 µM -1.17051140419672 0.144801223920111 no 2882 0.120897613754347 926 3674992
SGTC_716 1683-5115 658 µM -1.17135419038811 0.144625231080231 no 2883 0.120728218804888 966 723597
SGTC_2678 equilin 100 µM -1.17446935901424 0.143975964360486 no 2884 0.120103539024885 916 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3306 9127676 59.7925 µM -1.17459173471738 0.143950498881733 no 2885 0.12007904580571 953 41905287
SGTC_2307 7538926 6.34 µM -1.17485911790792 0.143894868988491 no 2886 0.120025541916092 958 96582
SGTC_2461 5755302 26.15 µM -1.17723216557871 0.143401784659735 no 2887 0.11955142676546 1002 2788904
SGTC_1988 st071872 53.4 µM -1.17859323601764 0.143119489691435 no 2888 0.119280093157915 971 16414116
SGTC_2074 5212007 75.395 µM -1.17958500884341 0.142914026075173 no 2889 0.119082654098214 950 758611
SGTC_994 3910-0338 138 µM -1.18109555789534 0.142601471803258 no 2890 0.11878238220162 971 3479481
SGTC_581 0958-0271 211 µM -1.18195539314075 0.142423766145146 no 2891 0.118611700393799 972 4591145
SGTC_2382 9035899 200 µM -1.1826955575355 0.14227091337455 no 2892 0.118464912737477 980 6462679
SGTC_3136 9095672 49.47 µM -1.18352910488869 0.142098908843207 no 2893 0.118299759360878 919 17217380
SGTC_1487 3970-0795 2.82 µM -1.18586500807295 0.141617639664731 no 2894 0.117837806940902 960 3765103
SGTC_1303 1160-0052 261 µM -1.19127271670189 0.140507723747952 no 2895 0.116773270477442 945 3562476
SGTC_37 0566-0070 1.56 µM -1.19383195345393 0.13998451229631 no 2896 0.116271854828694 963 1626686
SGTC_1997 st073024 93.8 µM -1.19426818329977 0.139895461519567 no 2897 0.116186539600723 969 686268
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.19810540695986 0.139113800047714 no 2898 0.11543799208312 976 1273210
SGTC_1464 k208-0027 110 µM -1.1981752413425 0.139099602035173 no 2899 0.115424400946989 939 X1464
SGTC_2742 clothiapine 36.27 µM -1.20017708220967 0.138693027565433 no 2900 0.115035286979511 969 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1976 st070609 63.5 µM -1.20067550872479 0.138591922987742 no 2901 0.114938549008603 960 682556
SGTC_3142 9086498 49.47 µM -1.20349973917459 0.138019983359416 no 2902 0.114391496120026 936 25236367
SGTC_1637 st007924 17.4 µM -1.20746548666701 0.13721959386785 no 2903 0.113626464445392 940 683336
SGTC_3119 9125183 49.47 µM -1.20845298276227 0.137020785844477 no 2904 0.11343653526428 948 22695334
SGTC_561 1550-0330 72.9 µM -1.20972907354563 0.136764168017536 no 2905 0.11319143495579 978 6812934
SGTC_3157 9099274 49.47 µM -1.20992318150796 0.136725162327391 no 2906 0.113154185536723 963 17217662
SGTC_3213 9129884 49.47 µM -1.21083897615017 0.136541237426261 no 2907 0.112978562044496 974 17190742
SGTC_2028 5153890 36.43 µM -1.21223896654946 0.13626039558151 no 2908 0.112710459691066 988 2830968 YPR165W RHO1
SGTC_3271 9137798 49.47 µM -1.2123559147369 0.136236953361194 no 2909 0.112688084340783 916 6498326
SGTC_1048 3161-0300 24.5 µM -1.21324306381931 0.136059214533574 no 2910 0.112518452028679 967 2165101
SGTC_1891 st059073 26.2 µM -1.21484109640626 0.135739452014707 no 2911 0.112213351614413 977 688754
SGTC_1191 1487-1166 10.6 µM -1.2179549067763 0.135117865535999 no 2912 0.111620554583124 1017 3955771
SGTC_2273 7815444 169.05 µM -1.21891700739301 0.134926203969423 no 2913 0.111437846915461 980 2824616
SGTC_3007 9078383 71.4286 µM -1.22214815796087 0.134283886706575 no 2914 0.110825802194761 981 6496995
SGTC_23 0213-0011 39.996 µM -1.22244146160224 0.13422568529984 no 2915 0.110770364068395 987 627608
SGTC_942 3253-1115 227 µM -1.22277412821344 0.134159693915461 no 2916 0.110707509892195 985 46497897
SGTC_2533 agelasine 13.65 µM -1.22520876688148 0.133677410810088 no 2917 0.110248286083645 960 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2130 NSC 7 2.4545 µM -1.22542911632174 0.133633820187321 no 2918 0.110206791086696 981 21448
SGTC_3150 9097574 49.47 µM -1.22699025155822 0.133325268567816 no 2919 0.109913127463148 962 17217476
SGTC_102 gallobenzophenone 83.616 µM -1.22705418960673 0.13331264194609 no 2920 0.109901112121253 957 70837
SGTC_734 2023-0417 80 µM -1.22795899422617 0.133134047403802 no 2921 0.109731180811053 989 3935732
SGTC_2078 5212016 200 µM -1.23131610186214 0.132472845150735 no 2922 0.109102330960364 978 1899708
SGTC_2935 9038016 29.96 µM -1.2313993881782 0.132456470232564 no 2923 0.109086762847401 967 6463195
SGTC_2768 sulfasalazine 50.2 µM -1.23164488264097 0.132408211694276 no 2924 0.109040883618963 997 5384001 An antioxidant and salicylic acid derivative.
SGTC_1216 1165-0504 9.65 µM -1.23234582350423 0.132270489611753 no 2925 0.108909964630224 1000 6304004
SGTC_800 3448-7362 155 µM -1.23432575604093 0.131882002536379 no 2926 0.108540771085684 992 15991913
SGTC_1795 st049545 62.3 µM -1.23543081675275 0.131665518628862 no 2927 0.108335104805172 930 5291882
SGTC_697 0508-1955 564 µM -1.23642267120215 0.131471421025421 no 2928 0.10815074664241 976 6243113
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.23670946068054 0.131415335560681 no 2929 0.108097482568274 985 2333 A French combination drug.
SGTC_403 arphamenine a 50 µM -1.23717622912301 0.131324088161277 no 2930 0.108010832226106 989 5487158 An arginine aminopeptidase inhibitor.
SGTC_2998 9066762 71.4286 µM -1.23847329020714 0.131070758655976 no 2931 0.10777030994842 978 4945196
SGTC_3197 9113331 49.47 µM -1.23881114155075 0.131004828236369 no 2932 0.107707723411689 967 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2744 captopril 92.04 µM -1.23922998559805 0.130923124211707 no 2933 0.107630169437064 985 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2474 5321570 43.32 µM -1.23998731717556 0.130775480741731 no 2934 0.107490042620097 994 2841384
SGTC_2804 7954240 19.48 µM -1.24484044877806 0.129832083896221 no 2935 0.106595202255531 968 828705
SGTC_3257 9139206 32.98 µM -1.24640995005661 0.129528000517122 no 2936 0.106306965086276 987 4910041
SGTC_848 0368-0089 85.6 µM -1.24768416037678 0.129281491515666 no 2937 0.106073372098045 977 762535
SGTC_935 2996-0153 430 µM -1.24868312664191 0.129088458816808 no 2938 0.105890497384038 988 23738523
SGTC_3011 9081274 71.4286 µM -1.25164528719721 0.128517248466511 no 2939 0.105349572404711 988 6625322
SGTC_2350 9023895 38.85 µM -1.2519672275841 0.128455272721604 no 2940 0.105290902997991 949 2997209
SGTC_2398 5228213 48.84 µM -1.25299923324832 0.128256744368979 no 2941 0.105102992870098 993 80771 YMR134W ERG29
SGTC_1556 plumbagin 1.48 µM -1.25512275197893 0.127848910655116 no 2942 0.104717101132284 941 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1996 st072960 66.8 µM -1.2560670676576 0.127667839312662 no 2943 0.104545827457405 968 1719405
SGTC_1220 1838-0075 193 µM -1.25670083453441 0.127546415328831 no 2944 0.104430992913374 956 5529645
SGTC_2469 5655019 90.81 µM -1.26113134522419 0.126699812408802 no 2945 0.103630764486318 989 2788239
SGTC_955 1216-0110 33 µM -1.26252870465492 0.126433611941577 no 2946 0.103379302049251 979 3619719
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.26373871258568 0.126203417411892 no 2947 0.103161912628019 971 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1618 st003135 44.5 µM -1.26654868516636 0.125669969502059 no 2948 0.102658355393261 1001 1270615
SGTC_107 0358-0022 2.6945 µM -1.26680863991 0.125620699059676 no 2949 0.102611861005854 1011 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_120 rhodamine 6G 52.259 µM -1.27021300345528 0.124976697928626 no 2950 0.102004383472738 998 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2771 fluoxetine 41.05 µM -1.2714171963357 0.124749454709887 no 2951 0.101790134061896 972 3386 A selective serotonin reuptake inhibitor.
SGTC_2863 9028737 58.44 µM -1.27212819972787 0.124615416931032 no 2952 0.101663786595313 985 6460917
SGTC_1284 0929-0043 16 µM -1.27539382998576 0.12400107614229 no 2953 0.101084940726605 993 1239883
SGTC_29 0299-0004 12.984 µM -1.27592905464574 0.123900590466195 no 2954 0.100990299611657 988 16871 A napthoquinone isolated from Swertia calycina.
SGTC_522 1273-0010 11.6 µM -1.28154705727316 0.122849277481809 no 2955 0.100000791196403 954 5705015
SGTC_1483 3453-0561 55.9 µM -1.28208527494801 0.122748888600508 no 2956 0.099906366919456 987 4546991
SGTC_1023 4482-3888 16 µM -1.28335674552698 0.122511961231804 no 2957 0.0996835602681264 984 3303168
SGTC_2201 6605497 169.863 µM -1.2840641276725 0.122380285795011 no 2958 0.0995597591645185 994 670741
SGTC_249 wiskostatin 11.211 µM -1.28454101577202 0.122291571675059 no 2959 0.099476360958692 961 2775510 A n-wasp and actin depolymerizer.
SGTC_3133 9127736 49.47 µM -1.28577838355659 0.122061598259011 no 2960 0.0992602081879744 962 27243420
SGTC_324 1315-0088 19.6 µM -1.28657415810204 0.121913858580104 no 2961 0.0991213778363792 995 6787421
SGTC_2938 9059746 27.26 µM -1.28805587287981 0.121639105310867 no 2962 0.0988632572455474 998 6471769
SGTC_2151 5563267 85.4165 µM -1.29108158222144 0.121079402578396 no 2963 0.0983376949102379 1016 5310824
SGTC_1194 1488-0194 225 µM -1.2911173668286 0.12107279391699 no 2964 0.0983314914305555 991 1391452
SGTC_644 1498-1197 63.3 µM -1.29326614139776 0.120676425636836 no 2965 0.0979595133900083 1002 6741615
SGTC_2747 doxorubicin 7.63 µM -1.29369161672156 0.120598049879013 no 2966 0.0978859811007415 939 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3034 9090421 49.47 µM -1.29555414117704 0.120255380716561 no 2967 0.0975645685683124 971 17173761
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.30292639919102 0.118905758409004 no 2968 0.096299945101183 972 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2207 7258803 200 µM -1.30327312808444 0.118842547993068 no 2969 0.0962407658992838 988 3666799
SGTC_1688 st021091 57.6 µM -1.30400876422183 0.118708516441248 no 2970 0.096115297084206 1032 3656366
SGTC_1265 0819-1001 68.8 µM -1.30503635969474 0.118521469269348 no 2971 0.0959402335781093 986 3106768
SGTC_1359 1582-0056 520 nM -1.30582759184233 0.118377587930008 no 2972 0.0958055973446764 1008 3661189
SGTC_161 4065-0411 162.148 µM -1.30762309268239 0.118051543814463 no 2973 0.095500590175045 995 1906281 YLR208W SEC13
SGTC_945 3381-0768 11.3 µM -1.30964574166821 0.117685013370629 no 2974 0.095157853349653 1000 1126236 YIL048W NEO1
SGTC_632 0781-2353 4.65 µM -1.30983219389784 0.117651266380227 no 2975 0.095126304773729 1013 6811515 YHR007C ERG11
SGTC_571 k831-0106 44.2 µM -1.31220927564311 0.11722162583105 no 2976 0.0947247665185902 984 4783639
SGTC_1132 3456-3614 2.5 µM -1.31429390096813 0.116845760402041 no 2977 0.0943736594734906 994 3125502
SGTC_858 0438-0351 2.77 µM -1.31474005616416 0.116765428125928 no 2978 0.0942986397623646 1003 2799119
SGTC_786 4544-0069 423 µM -1.31582172068396 0.116570832054318 no 2979 0.0941169435825772 971 748821 YLR208W SEC13
SGTC_2295 7971645 200 µM -1.31969005662325 0.115876784268204 no 2980 0.0934692606087903 1010 2978226 YKL099C UTP11
SGTC_2545 solidagenone 89.61 µM -1.32086532500044 0.11566650269287 no 2981 0.0932731366845915 950 6708572 An anti ulcer agent
SGTC_2401 5128683 200 µM -1.32216642268282 0.115434023773286 no 2982 0.0930563696994807 1006 708373
SGTC_2462 5162487 171.77 µM -1.32602231718408 0.114747006896418 no 2983 0.092416152637054 1006 2259986
SGTC_1276 0871-0068 94.2 µM -1.32676186856755 0.114615571883932 no 2984 0.0922937339223998 992 3414906
SGTC_1135 dihydrocapsaicin 536.708 nM -1.32818411245861 0.114363108190257 no 2985 0.092058645814968 1000 107982 A Capsaicinoid.
SGTC_3339 9145883 14.936 µM -1.32854453450007 0.114299192304227 no 2986 0.0919991407600727 956 2030670
SGTC_958 1222-0007 33 µM -1.32958240355016 0.114115282613435 no 2987 0.0918279494765126 991 7312461
SGTC_774 k060-0086 136 µM -1.33121264415252 0.113826830821046 no 2988 0.0915595260568005 1010 5911235
SGTC_2959 9079155 11 µM -1.33383173320428 0.113364502646246 no 2989 0.0911295042835171 1000 16189457
SGTC_337 1315-0038 354 µM -1.33850900169772 0.112542194244471 no 2990 0.0903652839666074 992 1626437
SGTC_751 0833-0568 350 µM -1.34013157742413 0.112257927767835 no 2991 0.090101285774508 1010 6954252
SGTC_3096 9117468 49.47 µM -1.34035788580403 0.112218320577574 no 2992 0.0900645102665052 969 41316311
SGTC_1644 st010134 20.9 µM -1.34061551473251 0.11217324400281 no 2993 0.0900226586902707 1000 3818134
SGTC_3049 9092223 49.47 µM -1.34098671174707 0.112108319513731 no 2994 0.08996238349782 1004 8623917
SGTC_3108 9121785 49.47 µM -1.34233182115772 0.111873277200844 no 2995 0.0897442150701616 936 17140271
SGTC_1010 4112-3296 15.2 µM -1.34407671394063 0.111568902737209 no 2996 0.0894617906128941 978 704384
SGTC_2780 5215298 71.43 µM -1.34437560580893 0.111516824332272 no 2997 0.0894134790297355 1001 2834131
SGTC_1061 3448-9325 110 µM -1.3462628860786 0.111188389537963 no 2998 0.0891088752920572 995 723482
SGTC_2518 prenyletin 46.28 µM -1.34757088220044 0.110961171633761 no 2999 0.088898220540355 987 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1455 4262-0120 131 µM -1.34976738586544 0.110580355655377 no 3000 0.0885453047243754 988 1529587
SGTC_67 0335-0847 266 µM -1.354032677817 0.10984354388958 no 3001 0.087862976263161 1012 4552207 YOR254C SEC63
SGTC_1142 3253-1408 9.78 µM -1.35493409806674 0.109688279288982 no 3002 0.0877192773189736 1012 256655
SGTC_2129 girgensonine 121.053 µM -1.35775538839039 0.109203346223487 no 3003 0.0872706574846691 1003 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2586 curcumin 80 µM -1.36059882412086 0.108716167292989 no 3004 0.0868202517030394 1023 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2126 5251174 33.877 µM -1.36280999439357 0.108338399068748 no 3005 0.0864712002360388 1007 790722
SGTC_939 1165-0479 45.3 µM -1.3672994086984 0.107574311304662 no 3006 0.0857657384876956 981 1377347
SGTC_2493 resveratrol 26.09 µM -1.36905668047588 0.107276287733096 no 3007 0.085490779003381 982 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3048 9093155 49.47 µM -1.37082266866282 0.106977386071434 no 3008 0.085215121292877 984 25236002
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.37087093043397 0.10696922598537 no 3009 0.0852075973467402 1022 75037 A free radical scavenger.
SGTC_2669 eugenol 100 µM -1.37539360698431 0.10620652458294 no 3010 0.0845047249502511 997 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2920 7982904 15.77 µM -1.37755660814048 0.105843149165195 no 3011 0.0841701129204091 1012 6456808
SGTC_2288 7946289 167.31 µM -1.37869090546434 0.105652951391421 no 3012 0.083995037367662 1015 1246052
SGTC_2520 obtusaquinone 4.71 µM -1.37940005519893 0.105534167527688 no 3013 0.0838857211280188 981 5967872
SGTC_936 3005-4620 401 µM -1.37941761383389 0.105531227650318 no 3014 0.0838830158005935 1000 777207
SGTC_1406 3909-7906 11.9 µM -1.38170915353516 0.105148058666497 no 3015 0.0835305113436157 976 X1406
SGTC_1885 st057546 99.9 µM -1.38311371413681 0.104913699935498 no 3016 0.0833150006244313 969 702008
SGTC_2158 5657123 3.6195 µM -1.38390453393817 0.104781913782419 no 3017 0.083193844151718 1023 2858827
SGTC_3231 9132313 49.47 µM -1.38563269502218 0.104494341706379 no 3018 0.0829295447156072 1001 4905967
SGTC_1969 st069479 40.1 µM -1.38692762225872 0.104279236326496 no 3019 0.0827319170118604 998 3895485
SGTC_3148 9097893 49.47 µM -1.38719048286525 0.104235610746648 no 3020 0.0826918433646985 974 17174100
SGTC_2620 irigenin 100 µM -1.38737452406884 0.104205074279357 no 3021 0.0826637945952524 992 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_4 0960-0234 25.671 µM -1.38947952234735 0.103856270107399 no 3022 0.0823434918053043 987 6821112
SGTC_2003 4023581 200 µM -1.39711425906655 0.102598279309446 no 3023 0.0811896072841887 995 16641307
SGTC_1465 k213-0056 144 µM -1.39849689103892 0.102371649921404 no 3024 0.0809819528097132 963 24048857 YMR208W ERG12
SGTC_232 clozapine 119 µM -1.40041865578736 0.10205725539292 no 3025 0.0806939933321899 1015 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1705 st027868 56.3335 µM -1.40895373531727 0.100669431442903 no 3026 0.079424424372704 982 292948
SGTC_158 k038-0087 26.446 µM -1.40961160238476 0.100563034895229 no 3027 0.0793271995992382 977 X158
SGTC_3162 9099653 49.47 µM -1.41201924662863 0.100174347169066 no 3028 0.0789721470937742 1004 25237511
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.4156485485024 0.0995905106309068 no 3029 0.0784392147626759 982 6708630 An antioxidant.
SGTC_2338 7999974 200 µM -1.42116433130331 0.098707968034983 no 3030 0.0776344957233128 999 315925
SGTC_3139 9095020 49.47 µM -1.42121902765703 0.0986992452011221 no 3031 0.0776265473633004 980 25236292
SGTC_3287 9117173 37.0625 µM -1.42173876079744 0.0986163876451398 no 3032 0.0775510516525613 963 2789709
SGTC_283 0987-0079 11.7 µM -1.42497262873717 0.0981019776619167 no 3033 0.077082556665675 1013 411556
SGTC_2748 diazoxide 86.69 µM -1.42885763707924 0.097486593989303 no 3034 0.0765225777512739 985 3019 A potassium channel activatior.
SGTC_2839 9003951 25.97 µM -1.42914959343018 0.0974404628645944 no 3035 0.0764806209682744 987 2990634
SGTC_674 0498-0004 451 µM -1.43003982931843 0.0972998982836674 no 3036 0.0763527940110691 970 4231473
SGTC_11 0438-0307 1.3 µM -1.43463535032904 0.0965766501528359 no 3037 0.0756955178140708 1015 4011476
SGTC_2551 apiole 73.87 µM -1.4352316023907 0.0964831015577923 no 3038 0.0756105554874853 1010 10659 A possible DNA adduct former.
SGTC_3188 9110789 49.47 µM -1.43617717548983 0.096334882996566 no 3039 0.075475966020776 1019 849217
SGTC_683 panaxydol 45 µM -1.43697302876459 0.0962102627626216 no 3040 0.0753628286983615 1015 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1886 st057356 49.9 µM -1.43864936460088 0.0959481582131699 no 3041 0.0751249462317978 1010 24207747
SGTC_2331 7980721 200 µM -1.44109197671703 0.0955671826622449 no 3042 0.0747793499616212 996 2981221
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.44840225843863 0.0944336469510478 no 3043 0.0737522917781213 1003 17037758
SGTC_57 miconazole 162.5 nM -1.44883892904975 0.0943662517319362 no 3044 0.0736912847041736 986 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_424 splitomicin 100 mM -1.45189597253465 0.093895424424877 no 3045 0.0732652662896787 1027 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3183 9108214 49.47 µM -1.45499040960947 0.0934206060084242 no 3046 0.0728359582758425 1018 4974831
SGTC_976 1348-1067 47.6 µM -1.45767927552655 0.0930094616415716 no 3047 0.0724644834831158 1021 5310671 YGL099W LSG1
SGTC_1791 st048313 56.1 µM -1.45783029573495 0.0929864094438517 no 3048 0.0724436627220179 991 1204976
SGTC_1872 amphotericin b 148 nM -1.45809238833743 0.0929464128336606 no 3049 0.0724075395798038 1001 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1753 st043925 64 µM -1.45904303389799 0.0928014464091124 no 3050 0.0722766318245848 1026 670181
SGTC_1086 cerivastatin 2.18 µM -1.45990123143671 0.0926707212802299 no 3051 0.0721586103786622 998 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1400 3771-8998 51.5 µM -1.46519595982661 0.0918672116842038 no 3052 0.0714337307865985 1038 670767
SGTC_3095 9117207 49.47 µM -1.46520744796229 0.0918654739127124 no 3053 0.0714321640916491 1025 17015229
SGTC_1079 idarubicin 2.36 µM -1.46549398825315 0.0918221378071474 no 3054 0.0713930956795903 1007 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2384 9036245 200 µM -1.46556813447536 0.0918109264632278 no 3055 0.0713829888646744 989 6462766
SGTC_1855 st056195 39.6 µM -1.46577909208846 0.0917790339807136 no 3056 0.0713542394006022 981 4028379
SGTC_1403 3909-7815 62.9 µM -1.46695534455445 0.0916013590694651 no 3057 0.0711941017260816 1003 6615483
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.46964024522203 0.0911967554069358 no 3058 0.0708296071693953 1010 77254
SGTC_2692 st077426 47.7 µM -1.47281323061036 0.0907203096282575 no 3059 0.0704007018968242 1029 25238571
SGTC_487 nimodipine 119 µM -1.47308058989497 0.0906802483191824 no 3060 0.0703646532776768 1051 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3060 1327-0027 12.5 µM -1.47460424887035 0.0904521927537881 no 3061 0.070159485969574 980 16000455 YPR107C YTH1
SGTC_3029 9088683 49.47 µM -1.47580128131987 0.0902733243358465 no 3062 0.0699986233425966 1011 25236615
SGTC_2159 5658611 73.75 µM -1.47633669583841 0.090193404281785 no 3063 0.0699267638371659 1014 793844
SGTC_2463 5473429 200 µM -1.47868706071195 0.0898431925972573 no 3064 0.0696119860588183 1005 5399405
SGTC_1567 st069303 68.4 µM -1.47886311672143 0.0898170004508153 no 3065 0.0695884513626048 1010 5581319
SGTC_496 calpeptin 138 µM -1.47904522429912 0.0897899139746903 no 3066 0.0695641141552097 1007 73364 A calpain inhibitor.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.48400428441366 0.0890546411510879 no 3067 0.0689038919842523 976 4000243
SGTC_2828 7998861 71.43 µM -1.4848202769405 0.0889340856909686 no 3068 0.0687957195262046 995 2988188
SGTC_110 0850-0284 111.64 µM -1.48532593067627 0.0888594409542453 no 3069 0.0687287530234038 989 3906265
SGTC_987 1497-1013 404 µM -1.48765195257474 0.0885166737370573 no 3070 0.0684213524180458 1023 1676435
SGTC_1004 4084-0029 199 µM -1.48823089176156 0.0884315134017757 no 3071 0.0683450065366479 1027 716894 YLR208W SEC13
SGTC_1790 st045711 43.5 µM -1.49544767183459 0.0873750636436791 no 3072 0.0673988234725376 992 585119
SGTC_3333 9141820 12.094 µM -1.49694899120807 0.0871564772483073 no 3073 0.0672032655836776 1002 1939433
SGTC_1727 st034309 9.9045 µM -1.5023776389291 0.0863694942397461 no 3074 0.0664998039669602 1027 870305
SGTC_3284 9108171 64.8615 µM -1.50455577051827 0.0860552318183114 no 3075 0.0662191623786003 997 8687505
SGTC_986 1493-0483 84 µM -1.50641934098206 0.0857870342868359 no 3076 0.0659797793759983 1016 40079
SGTC_639 0833-0042 114 µM -1.50780678167448 0.0855877660907647 no 3077 0.0658019929849326 1029 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_968 1309-0633 340 µM -1.51202935963427 0.0849834399858895 no 3078 0.0652631968672405 1021 3761976
SGTC_255 tunicamycin 200.472 nM -1.51317205513779 0.0848204511185006 no 3079 0.0651179802827594 994 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2522 biochanin a 4.94 µM -1.51459138683676 0.084618330626691 no 3080 0.0649379573858326 1023 5280373 A possible chelator.
SGTC_452 diindolylmethane 8 µM -1.5195363568427 0.0839169617375845 no 3081 0.0643137719008897 1025 3071 Inhibits expression of several cancer promoting factors.
SGTC_3342 9147791 14.508 µM -1.51987639937958 0.0838688927731985 no 3082 0.0642710215051026 1010 1838168
SGTC_1989 st071868 50.2 µM -1.52058445210835 0.0837688676559247 no 3083 0.0641820754745878 1015 16414057
SGTC_2572 astragaloside iv 100 µM -1.52063837053349 0.0837612543868426 no 3084 0.0641753061305225 1018 45006101 An anti-inflammatory agent.
SGTC_1497 4476-2978 41.3 µM -1.52123213299102 0.083677449640003 no 3085 0.0641007972140593 1004 1528379
SGTC_1739 st037196 92.5 µM -1.52138447145507 0.0836559584611344 no 3086 0.064081691704055 1009 612214
SGTC_2745 rifampicin 24.3 µM -1.52248754670587 0.0835004656159715 no 3087 0.0639434817180518 1027 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2320 7373003 200 µM -1.52253380690047 0.083493949386723 no 3088 0.0639376906082449 1008 5415828
SGTC_477 mead ethanolamide 10 µM -1.52486439288683 0.0831661565196937 no 3089 0.0636464623641693 1038 16061185
SGTC_465 cgp-37157 41 µM -1.52543219891695 0.0830864423819026 no 3090 0.0635756663511033 1027 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_72 0744-0168 198.391 µM -1.5258404795478 0.0830291594952064 no 3091 0.063524798398271 1037 677577
SGTC_2629 bisabolol 100 µM -1.52647240981264 0.0829405565288494 no 3092 0.0634461282486905 1033 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_992 3909-8734 162 µM -1.53007256989918 0.0824371343350052 no 3093 0.0629993835094247 1039 4288319
SGTC_2161 5662504 8.5105 µM -1.53191674162072 0.0821801504738693 no 3094 0.0627714908186828 980 2859334
SGTC_2262 9014885 67.46 µM -1.53258531145356 0.0820871349833556 no 3095 0.0626890314442599 1040 6457424
SGTC_2770 toltrazuril 17.5 µM -1.53351965037197 0.0819572769876251 no 3096 0.062573934380924 1003 68591 Kills coccidiodes.
SGTC_892 0929-0076 29 µM -1.53469718736856 0.0817938389459441 no 3097 0.0624291135297259 1019 5751038
SGTC_568 1193-0097 7.48 µM -1.53634614882253 0.0815653818683984 no 3098 0.0622267533513453 960 3646150
SGTC_3021 9087658 49.47 µM -1.5380912803276 0.0813241252248389 no 3099 0.062013148857727 1018 25237042
SGTC_2219 9098279 200 µM -1.54724489330409 0.08006748867196 no 3100 0.0609021021697817 1028 902349
SGTC_2741 miltefosine 3.04 µM -1.54780219240578 0.0799914576633117 no 3101 0.0608349642498732 1023 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_645 0845-0943 5.41 µM -1.54951664704715 0.0797579009205208 no 3102 0.0606287864393086 1024 1885106
SGTC_2246 7293507 91.5585 µM -1.5504805448057 0.0796268177705633 no 3103 0.0605131097745028 1030 887656
SGTC_2324 6149169 200 µM -1.55200585694258 0.0794197194512745 no 3104 0.060330411098409 1027 2888231
SGTC_2843 9000894 45.46 µM -1.55900451361274 0.0784747048845363 no 3105 0.0594976559340217 1000 2242070
SGTC_791 1348-1292 225 µM -1.56145716645978 0.0781455531007207 no 3106 0.0592079613522657 1040 5437054
SGTC_435 c-PAF 6.7 µM -1.5664218518968 0.0774824874871256 no 3107 0.0586249452673108 1008 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1341 1486-1360 280 µM -1.57399359816201 0.0764794712998871 no 3108 0.0577444647331488 1039 3976547
SGTC_250 brefeldin a 552.239 µM -1.57488734372041 0.0763617331341629 no 3109 0.0576412252630507 1048 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_540 1187-0821 17.3 µM -1.57698671566526 0.0760857134911811 no 3110 0.0573992908948568 1031 847520
SGTC_2182 6325192 200 µM -1.57729960476355 0.0760446408108918 no 3111 0.0573633016547395 1010 736248
SGTC_2909 7941780 10.49 µM -1.57851641535998 0.075885071595707 no 3112 0.0572235099957776 1009 1243215
SGTC_2009 4012297 12.05 µM -1.5786292465658 0.0758702881477504 no 3113 0.0572105611283842 1008 45595307
SGTC_702 1488-0190 94 µM -1.57864008943115 0.0758688676018979 no 3114 0.0572093168881971 1023 949357
SGTC_2341 7987486 176.74 µM -1.58014885959428 0.075671397990785 no 3115 0.0570363901040427 1029 1258686
SGTC_1174 0739-0097 51.1 µM -1.58280440910886 0.0753247879526762 no 3116 0.056733025735013 1037 728447
SGTC_973 1325-0077 65.9 µM -1.58618702406705 0.0748850334278724 no 3117 0.056348445210078 1044 2835149
SGTC_2859 9028643 45.46 µM -1.5889778409177 0.0745236919656747 no 3118 0.0560326977932257 993 17151580
SGTC_1054 3429-0080 167 µM -1.5938043427633 0.0739019232088064 no 3119 0.0554899322862931 1042 1162877
SGTC_1340 1486-1359 257 µM -1.59583768011587 0.0736411706914895 no 3120 0.0552625191284875 1018 4309068
SGTC_3190 9110366 49.47 µM -1.59716337980948 0.073471543866886 no 3121 0.0551146466487707 1034 17123768
SGTC_1596 piperlongumine 63 µM -1.5990793603945 0.0732269172229269 no 3122 0.0549014850467237 1013 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1924 st058459 75.1 µM -1.59938839804005 0.0731875186532668 no 3123 0.0548671642986128 1019 688683
SGTC_1974 st069448 26.9 µM -1.60060443006607 0.0730326467055213 no 3124 0.0547322802244284 1021 6323587 YNR016C ACC1
SGTC_622 1348-1566 26.3 µM -1.60996574728308 0.0718487894956438 no 3125 0.053702667098511 1035 7340407
SGTC_2616 abietic acid 100 µM -1.61044225930782 0.0717889244787642 no 3126 0.0536506706211056 1039 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_959 1222-0044 107 µM -1.61106412827721 0.0717108555735412 no 3127 0.0535828729410269 1019 6083612
SGTC_84 0443-0269 128.823 µM -1.6113142191854 0.0716794777402239 no 3128 0.0535556265607417 1022 6150058
SGTC_535 2293-4129 48.2 µM -1.61316725282969 0.0714473136052081 no 3129 0.0533540879493231 1049 396118 YIL048W NEO1
SGTC_2646 retinol 96.75 µM -1.61926782848346 0.0706870568759391 no 3130 0.0526948247725232 1015 445354 A vitamin A analog and teratogen.
SGTC_2752 diclazuril 33.15 µM -1.62104014259409 0.0704673597024289 no 3131 0.0525045149117751 1011 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1306 1185-0270 9.02 µM -1.6230011771479 0.0702248807895912 no 3132 0.0522945766146865 1041 1548076
SGTC_1796 st049173 110.4 µM -1.62413983950026 0.0700843817087826 no 3133 0.0521729834891222 1029 94134
SGTC_1345 1488-0192 31.4 µM -1.62987327426164 0.0693802190648952 no 3134 0.0515641415942304 1035 658348
SGTC_385 1494-0393 12.4 µM -1.63426937356225 0.0688440045788315 no 3135 0.0511011507368622 1047 3090647
SGTC_3261 9137475 49.47 µM -1.63428426132726 0.0688421940867195 no 3136 0.0510995884185052 1011 17027690
SGTC_1200 1643-0193 18.4 µM -1.63465399040448 0.0687972433315494 no 3137 0.0510608013335858 1040 5403974
SGTC_1388 3346-4487 254 µM -1.6349677029369 0.0687591206804081 no 3138 0.0510279091421845 1051 3345614
SGTC_2107 5363541 170.161 µM -1.63514783215094 0.0687372385663752 no 3139 0.0510090305429175 1031 244052
SGTC_2411 st077133 39.94 µM -1.63549959935385 0.0686945213362503 no 3140 0.0509721793036101 1034 1403142 YNL221C POP1
SGTC_2096 5468907 200 µM -1.63834064502746 0.0683502658901155 no 3141 0.0506753266954665 1051 759785
SGTC_718 1130-0073 349 µM -1.63910852601889 0.068257449049199 no 3142 0.0505953298552442 1043 6740020
SGTC_1397 3532-0190 20.1 µM -1.64010712233491 0.0681368902656475 no 3143 0.0504914478970346 1047 5322280
SGTC_1626 st003712 1.76 µM -1.64061730753607 0.0680753599734232 no 3144 0.0504384399849856 1031 24207035
SGTC_2444 5485484 36.41 µM -1.64063634636793 0.0680730646477911 no 3145 0.0504364627212249 1051 6790631
SGTC_453 enantio-paf c16 10 µM -1.64169942420767 0.0679449945407707 no 3146 0.0503261555284864 1022 13871343 A lipid and platelet activating factor
SGTC_1920 st075728 45.7 µM -1.64508831579483 0.0675379729089487 no 3147 0.0499757998873448 1018 3400306
SGTC_2035 5154463 94.595 µM -1.6457631943228 0.0674571422866377 no 3148 0.049906261338557 1039 2769623
SGTC_1893 st059353 36.1 µM -1.64832028293126 0.0671515563546145 no 3149 0.0496434823537261 1040 3112488
SGTC_464 bw-b 70c 158 µM -1.65341995462247 0.0665453153509436 no 3150 0.0491227122398305 1044 5353454
SGTC_263 alizarin 107.927 µM -1.65349492302505 0.0665364349280471 no 3151 0.0491150892592768 1041 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_749 1000-0129 128 µM -1.65614006911831 0.0662236895499029 no 3152 0.0488467282623792 1044 708470
SGTC_1606 st000094 49.2 µM -1.65783798775538 0.0660235391323448 no 3153 0.0486750857658605 1031 1242210
SGTC_2670 beta-carotene 100 µM -1.66022019298105 0.0657435155885751 no 3154 0.0484350819019392 1020 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2435 5706476 10.6 µM -1.66059652661695 0.0656993626412753 no 3155 0.0483972535226428 1024 5725375
SGTC_2740 felodipine 17.08 µM -1.66704235445923 0.0649466764294386 no 3156 0.047752991624847 1047 3333 L-type calcium channel blocker
SGTC_1877 wortmannin 25 µM -1.66785819425628 0.064851889108782 no 3157 0.0476719401604375 1043 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1878 temozolomide 1 mM -1.67279099246991 0.0642810643755512 no 3158 0.0471842243634563 1029 5394 DNA alkylating agent.
SGTC_485 niflumic acid 177 µM -1.67434683022579 0.0641018347659575 no 3159 0.0470312279274237 1064 4488 A COX2 inhibitor.
SGTC_1751 st044839 27.194 µM -1.67519076096647 0.0640047781713675 no 3160 0.0469484048536421 1030 5291326
SGTC_938 3126-1755 342 µM -1.67576157473706 0.0639391963105139 no 3161 0.0468924517274928 1029 1777771
SGTC_466 geldanamycin 89.2 µM -1.67990415461807 0.0634648121984831 no 3162 0.0464879826706864 1045 5288382 HSP90 inhibitor.
SGTC_3334 9142812 21.919 µM -1.68297603594074 0.0631148104661072 no 3163 0.0461898653061154 1036 45283678
SGTC_1503 4585-0012 61.3 µM -1.68564915395255 0.0628114675482517 no 3164 0.0459316978524259 1041 2922052
SGTC_1320 1313-0481 95.3 µM -1.6865846513082 0.0627055769506267 no 3165 0.0458416226640125 1037 6813365 YLR208W SEC13
SGTC_2608 thymoquinone 42.66 µM -1.69027104500266 0.0622896613392631 no 3166 0.045488055962597 1039 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_99 0109-0120 622.8 µM -1.6949725932729 0.0617623370140821 no 3167 0.0450403099991027 1039 759414
SGTC_2708 st078559 56 µM -1.69930884023186 0.0612790801710781 no 3168 0.0446305038951418 1020 17250902
SGTC_602 3130-1533 38.1 µM -1.69964787666559 0.0612414208353513 no 3169 0.0445985895466013 1043 720941
SGTC_3249 9135183 49.47 µM -1.70354953584492 0.060809334547321 no 3170 0.0442326380642503 999 4902779
SGTC_565 1418-0001 44.5 µM -1.70383400901651 0.0607779242618189 no 3171 0.0442060511913392 1049 2862145
SGTC_2076 5212012 200 µM -1.70661125622065 0.060471938962424 no 3172 0.0439471657976714 1042 604802
SGTC_152 4469-0003 551.229 µM -1.71373247913962 0.0596928600457641 no 3173 0.0432889345083656 1038 697280
SGTC_1882 5615643 20 µM -1.71375425481414 0.0596904898533895 no 3174 0.0432869340090602 1006 2253075
SGTC_1561 5-methoxyflavone 52.9 µM -1.72126149299509 0.058877743692869 no 3175 0.0426016918299154 1020 94525
SGTC_887 0885-0007 9.62 µM -1.7218623635382 0.0588130696095159 no 3176 0.042547227103589 1060 5719458
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.72406313194925 0.0585766681055522 no 3177 0.0423482234060535 1058 368090
SGTC_705 1124-0212 310 µM -1.72537499700481 0.0584361058548347 no 3178 0.0422299571141539 1035 9554485
SGTC_3269 9137823 49.47 µM -1.72858930426792 0.0580928224165426 no 3179 0.0419413126251215 1025 17682936
SGTC_2899 9053889 58.44 µM -1.73353671748452 0.0575675446905785 no 3180 0.0415001586053314 1035 6470052
SGTC_2114 5491910 81.25 µM -1.7348958840666 0.0574238950408455 no 3181 0.0413796241659644 1047 2849228
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.73718301197184 0.0571828063202554 no 3182 0.0411774362498561 1026 88881 An O-methylated flavonoid and antioxidant.
SGTC_2978 9011784 42.97 µM -1.73846868605813 0.0570476321731447 no 3183 0.0410641315435377 1017 2994934
SGTC_2667 digitoxin 100 µM -1.74083448507731 0.0567995525304291 no 3184 0.0408562976409776 1032 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2248 tofa 1.1 µM -1.74365841037875 0.0565045466902817 no 3185 0.0406093357720912 1016 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1408 3909-7976 48.8 µM -1.74402227163719 0.0564666233171852 no 3186 0.0405776031719701 1050 24152374
SGTC_1854 st056233 32.9 µM -1.74733093528299 0.0561226982857923 no 3187 0.0402899749779186 1050 5393174
SGTC_2061 5245884 80.95 µM -1.74992414474282 0.055854298872265 no 3188 0.0400657018864244 1063 573863
SGTC_2489 cantharidin 73.42 µM -1.7584051073781 0.0549835785972767 no 3189 0.0393393023677334 1039 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_185 k048-0037 25.491 µM -1.76094958164401 0.054724445810294 no 3190 0.0391234684556607 1051 6827589
SGTC_3105 9121040 49.47 µM -1.76879909083906 0.0539311207372461 no 3191 0.0384637042740736 1021 41448907
SGTC_2123 5259487 200 µM -1.77300337644229 0.0535099668181315 no 3192 0.0381140736924039 1049 2173474
SGTC_2879 9041815 71.43 µM -1.78063195289271 0.052752450558253 no 3193 0.0374862981257147 1064 4942971
SGTC_3253 9135987 49.47 µM -1.78249048641171 0.0525691935289848 no 3194 0.0373346406369096 1044 4182430
SGTC_2275 7947463 200 µM -1.78727682164779 0.0520995721280804 no 3195 0.0369463791549598 1017 1225414
SGTC_2032 5185112 25.99 µM -1.79338729601914 0.0515048799859074 no 3196 0.0364555087534634 1034 5718189
SGTC_3251 9135047 49.47 µM -1.79597584398996 0.0512545870398252 no 3197 0.0362491794430901 1059 17682963
SGTC_1300 1094-0077 113 µM -1.80116935367516 0.0507553330162437 no 3198 0.0358380955679861 1055 5532636
SGTC_1500 4488-1866 171 µM -1.80209012244588 0.050667224665161 no 3199 0.0357656137581874 1059 2900003
SGTC_1579 chlormadinone acetate 49.4 µM -1.80265652098677 0.0506130865390165 no 3200 0.0357210872515014 1052 45114258 A steroidal progestin.
SGTC_3297 9117502 71.43 µM -1.80495941511335 0.0503934431498613 no 3201 0.0355405165681185 1047 7453720
SGTC_846 0335-0850 148 µM -1.80728070379014 0.0501728146742739 no 3202 0.0353592615617549 1050 6819598
SGTC_605 1315-0399 119 µM -1.80970213436006 0.0499434894075027 no 3203 0.0351709956845512 1062 24020461
SGTC_3205 9113483 49.47 µM -1.8109291427355 0.0498276032458127 no 3204 0.0350759103711226 1036 17018033
SGTC_2994 9053520 71.4286 µM -1.81333597807423 0.0496009100968179 no 3205 0.0348900087089499 1044 4647384
SGTC_1946 st076057 65.1 µM -1.81405495339467 0.0495333516872033 no 3206 0.0348346328949965 1052 953009
SGTC_3004 9076122 71.4286 µM -1.8189364229617 0.0490766050646148 no 3207 0.0344605650997306 1050 44782551
SGTC_2220 6782180 200 µM -1.81894742266364 0.049075579662571 no 3208 0.0344597259324543 1046 833803
SGTC_2662 daunorubicin 22.37 µM -1.819733714999 0.0490023251132891 no 3209 0.0343997831713779 1029 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2477 5967686 25.23 µM -1.81986556671972 0.0489900497676301 no 3210 0.0343897398882521 1057 776118
SGTC_3235 9132602 49.47 µM -1.83157720815473 0.0479094648008554 no 3211 0.0335072175245891 1053 4912240
SGTC_1590 st077108 57.8 µM -1.83533726288233 0.0475666146570418 no 3212 0.0332278665590692 1059 5489485
SGTC_1660 st012960 28.1 µM -1.8368848866374 0.0474260710468508 no 3213 0.0331134454323121 1050 24207266
SGTC_1935 st074532 41.6 µM -1.83983464717469 0.0471591174211774 no 3214 0.0328962585296452 1043 2829742
SGTC_1176 0848-0131 83.3 µM -1.85355934293072 0.0459328335463264 no 3215 0.0319011143933931 1065 6769040
SGTC_218 alverine citrate 93.75 µM -1.85908815609521 0.0454461377183713 no 3216 0.0315073218998517 1046 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_563 tetrahydrosecaminediol 614 µM -1.86541564223671 0.0448942339391439 no 3217 0.0310615832389649 1064 334274 A psychoactive constituent of the cannabis plant.
SGTC_1971 st069429 63.5 µM -1.86584199148246 0.0448572412637028 no 3218 0.0310317377149146 1050 1246522 YGL099W LSG1
SGTC_1834 st055981 52.8 µM -1.86876045068472 0.0446046763519425 no 3219 0.0308280747469543 1055 471719 YDL150W RPC53
SGTC_3176 9106582 49.47 µM -1.87311689222329 0.0442298000887874 no 3220 0.0305261226063168 1066 17018027
SGTC_2263 7948595 193.29 µM -1.87459120897852 0.0441035102832774 no 3221 0.030424491755642 1052 2971371
SGTC_182 3448-4371 550.524 µM -1.87464209558242 0.0440991565385357 no 3222 0.0304209889390869 1051 3491403
SGTC_1407 3909-7909 12.3 µM -1.87731282583054 0.0438711407175646 no 3223 0.030237615685232 1024 4411780
SGTC_2399 5884133 200 µM -1.87865771425577 0.0437566802800603 no 3224 0.0301456225779534 1065 722445
SGTC_328 k915-0120 63.5 µM -1.8787958316075 0.0437449390766021 no 3225 0.0301361882209742 1060 6624543
SGTC_1793 st048256 72.231 µM -1.88167011531343 0.0435011757351389 no 3226 0.029940409881405 1038 672022
SGTC_2814 7977482 42.97 µM -1.88226713397043 0.0434506813279457 no 3227 0.0298998772681083 1058 6456762
SGTC_889 0919-1524 82.7 µM -1.88452650677374 0.043260017189195 no 3228 0.0297468964181064 1060 3905452
SGTC_1758 st042942 75.2445 µM -1.88777102960961 0.0429874004745362 no 3229 0.0295283480021988 1053 669317
SGTC_183 3914-0051 30.55 µM -1.88819332387829 0.0429520200749035 no 3230 0.0295000008796917 1053 1596232
SGTC_1832 st054113 55 µM -1.89063207592698 0.0427481580951982 no 3231 0.0293367376735049 1055 1251267
SGTC_3042 9091578 49.47 µM -1.8955660460015 0.042338105978543 no 3232 0.0290087253129614 1043 25236497
SGTC_331 k048-0133 24.5 µM -1.90364599542729 0.0416734751099779 no 3233 0.0284781521096361 1062 6813582
SGTC_2027 5150920 200 µM -1.92245821435747 0.0401587600140709 no 3234 0.0272740632956805 1044 786715
SGTC_80 0159-0065 512.242 µM -1.93469791073142 0.0391974880116101 no 3235 0.0265136884577814 1062 1548079
SGTC_824 1304-0008 100 µM -1.9385494400808 0.0388989025756855 no 3236 0.0262781125661949 1062 768245
SGTC_1421 4029-0249 71.4 µM -1.93886294757115 0.0388746800071567 no 3237 0.0262590143702479 1059 2894095
SGTC_1332 1480-0653 17.5 µM -1.94339487621416 0.0385258993478562 no 3238 0.0259842329390174 1060 5749438
SGTC_534 k292-0788 63.4 µM -1.94950298276059 0.0380598541443121 no 3239 0.0256176934747637 1074 4146317
SGTC_3069 9117009 49.47 µM -1.96020350089873 0.0372545014605104 no 3240 0.0249860047350813 1060 41904981
SGTC_619 1652-1634 108 µM -1.96047894577114 0.0372339559122244 no 3241 0.0249699182396285 1070 5400454
SGTC_2175 5807670 165.306 µM -1.96607234285524 0.0368187411000365 no 3242 0.024645127320692 1046 241186
SGTC_1138 3761-0006 1.03 µM -1.97250547243826 0.0363458801014157 no 3243 0.0242759661064778 1069 12061087
SGTC_1117 retinoic acid 1.10837 µM -1.97474792653367 0.0361822235905934 no 3244 0.0241483805689285 1079 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2523 spermine 47.74 µM -1.97804184323085 0.0359429248006339 no 3245 0.023961993219652 1061 1103 A DNA binding polyamine.
SGTC_934 2950-0684 338 µM -1.98420123679909 0.0354989319323451 no 3246 0.0236167053696276 1056 1121253
SGTC_1742 st038235 28.8875 µM -1.98601849463051 0.0353687993865936 no 3247 0.0235156351782297 1056 564103 YBR002C RER2
SGTC_2861 9024595 19.48 µM -1.99158070029855 0.0349729231768054 no 3248 0.0232085413382745 1070 16482810
SGTC_988 1497-1057 103 µM -1.99265424940425 0.0348969362479882 no 3249 0.0231496601914021 1071 3533044
SGTC_1343 1487-0095 224 µM -1.99488744837951 0.0347393022577091 no 3250 0.0230275783878874 1067 4560101 YGL055W OLE1
SGTC_1257 0669-0121 16 µM -1.99679632323035 0.0346050251429631 no 3251 0.0229236565801885 1050 4307855
SGTC_587 k089-0003 57 µM -2.00776922148827 0.0338413974099247 no 3252 0.0223339104657911 1052 9659696
SGTC_746 1095-0025 46.6 µM -2.00838903129322 0.0337986804436967 no 3253 0.0223009837851391 1067 6749286
SGTC_3226 9131256 49.47 µM -2.00931245309093 0.0337351209862124 no 3254 0.0222520040306932 1055 17178073
SGTC_635 k038-0028 24.7 µM -2.01191240088611 0.0335566937430106 no 3255 0.0221145859719572 1072 4035102
SGTC_865 0488-0499 301 µM -2.02082626382456 0.0329508478528398 no 3256 0.0216488765173639 1061 9634651
SGTC_813 k007-0158 173 µM -2.02173880876928 0.0328893370951287 no 3257 0.0216016711610765 1063 6523916
SGTC_1861 st057647 17.4 µM -2.02517379475208 0.0326586474370612 no 3258 0.0214247607575821 1074 688668
SGTC_974 1326-0144 138 µM -2.031675285942 0.0322256677901228 no 3259 0.0210932697318421 1067 5411856
SGTC_3086 9117350 49.47 µM -2.03186849757537 0.0322128733258961 no 3260 0.0210834852358073 1068 2679265
SGTC_1508 1080-0625 72.9 µM -2.03546886585216 0.0319752231644421 no 3261 0.0209018590909461 1029 767111
SGTC_2252 omeprazole 400 µM -2.03865233001556 0.0317662995205094 no 3262 0.0207423692703674 1082 4594 A proton pump inhibitor.
SGTC_1034 k072-0165 12.7 µM -2.04213504640861 0.0315390297487794 no 3263 0.0205690686623838 1070 5835461
SGTC_151 3013-0144 2.285 µM -2.04468718908409 0.0313733406125503 no 3264 0.0204428537155493 1049 906558 YHR107C CDC12
SGTC_2847 9005661 71.43 µM -2.05202232629788 0.0309011347528285 no 3265 0.0200837463466118 1068 2991449
SGTC_1115 galangin 695.678 nM -2.05576949881762 0.0306621866083051 no 3266 0.0199023696655119 1078 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2699 st077704 54.6 µM -2.07047266210416 0.0297393353385041 no 3267 0.0192040517662396 1067 645852
SGTC_342 k048-0088 23.3 µM -2.0748957634455 0.0294662689130102 no 3268 0.0189980982239294 1069 6820570
SGTC_1346 1488-2224 62.4 µM -2.07875556977119 0.029229682143507 no 3269 0.0188199112551815 1060 3722427
SGTC_39 0986-0283 58.349 µM -2.08055662725871 0.0291198274405878 no 3270 0.0187372536830762 1052 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2916 7875993 68.79 µM -2.08618742066601 0.0287785901252676 no 3271 0.0184808246324072 1054 1299250
SGTC_1654 st012436 41.8 µM -2.0893183376767 0.0285902929210494 no 3272 0.0183395383771217 1078 4323132
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.09689237609692 0.0281390155953163 no 3273 0.0180015517898742 1049 279621
SGTC_2693 st077581 40.7 µM -2.09783214781463 0.0280834378297239 no 3274 0.0179599877920684 1028 25238761
SGTC_2480 5767542 37.17 µM -2.1008205658089 0.0279073109938802 no 3275 0.0178283602101613 1069 2867358
SGTC_3125 9127534 49.47 µM -2.10858100900607 0.0274542306859953 no 3276 0.0174903817738436 1059 1639235
SGTC_1938 st074717 56.4 µM -2.11825194995629 0.0268982096028367 no 3277 0.0170768678208269 1047 17250979
SGTC_2447 5741742 33.78 µM -2.12340740635458 0.0266056637622666 no 3278 0.016859863556141 1068 1776504
SGTC_60 0986-0278 202 µM -2.12714492151684 0.0263952447728349 no 3279 0.0167040219101797 1077 3110598
SGTC_1309 pyrazolanthrone 13.4 µM -2.15054643630083 0.0251091474759587 no 3280 0.0157560085038235 1072 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_763 3453-1109 128 µM -2.16065333662388 0.0245701605389016 no 3281 0.0153610640143463 1078 1560353
SGTC_449 xestospongin c 11.1929 µM -2.16600118311342 0.0242889172504949 no 3282 0.0151555482652563 1081 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_64 000l-0018 272.079 µM -2.20915007405996 0.0221171302774673 no 3283 0.0135821020874765 1052 6811119
SGTC_1222 0366-0074 1.18 µM -2.20972753423329 0.0220892147887397 no 3284 0.0135620388114182 1082 286520
SGTC_1619 st003326 88.7 µM -2.21443160761097 0.0218629171945514 no 3285 0.0133995513024603 1038 2849032
SGTC_2103 5378138 10 µM -2.2469636747065 0.0203508902015125 no 3286 0.0123211743583343 1076 244142
SGTC_3230 9131665 49.47 µM -2.25606836905937 0.0199439450180706 no 3287 0.0120331748577381 1069 15943720
SGTC_600 1495-0418 41.6 µM -2.26327623955605 0.0196266965221529 no 3288 0.0118093330187632 1076 5377768
SGTC_3012 9080433 71.4286 µM -2.26875846972145 0.019388279021007 no 3289 0.0116415088896334 1070 17688859
SGTC_886 0866-0150 153 µM -2.27375841576669 0.0191729855925027 no 3290 0.0114902578845419 1075 271463
SGTC_3195 9113082 49.47 µM -2.27384130327205 0.0191694337211612 no 3291 0.0114877649441385 1077 17018038
SGTC_1088 bifonazole 369 nM -2.27946967497302 0.018929553465075 no 3292 0.0113195803179773 1074 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2310 7668677 200 µM -2.27974937123798 0.0189176997522422 no 3293 0.0113112786542984 1069 2197143
SGTC_3128 9127691 49.47 µM -2.28892474832888 0.018532327416377 no 3294 0.0110418625248626 1069 41316314
SGTC_2045 5106652 78.05 µM -2.28941451243642 0.0185119462755561 no 3295 0.0110276398633624 1072 673349
SGTC_189 3970-0742 2.116 µM -2.29807499382216 0.018154687929385 no 3296 0.0107787606044533 1071 2891807
SGTC_2919 7978188 46.38 µM -2.31360265128519 0.0175288530071145 no 3297 0.010344764064512 1081 2980291
SGTC_1811 st050069 61.5 µM -2.31392888905127 0.0175159042001019 no 3298 0.010335811572543 1085 3877702
SGTC_164 4100-3994 89.624 µM -2.31417390688422 0.0175061844897747 no 3299 0.0103290923292908 1083 4615967
SGTC_1846 st056244 14.8 µM -2.3249026356838 0.0170850742016616 no 3300 0.0100385835097774 1077 5393182
SGTC_998 3996-0085 177 µM -2.33378110841062 0.0167431637532728 no 3301 0.00980359325230029 1086 715391
SGTC_2915 7971052 15.16 µM -2.3448821939656 0.0163239097973542 no 3302 0.00951654614916382 1069 5741558
SGTC_1451 4152-0210 104 µM -2.347880577898 0.0162122241771401 no 3303 0.00944028687139676 1075 659563
SGTC_2986 9022445 71.43 µM -2.36663678537088 0.0155283321603766 no 3304 0.00897526983020761 1063 6459286
SGTC_1270 0831-1170 17.3 µM -2.37226755338193 0.0153279167686963 no 3305 0.00883964168737834 1077 6764716
SGTC_891 0929-0073 133 µM -2.39499494622656 0.0145414015026847 no 3306 0.00831029717908199 1088 5603632
SGTC_3017 9080681 49.47 µM -2.40620449005483 0.0141664398200117 no 3307 0.00805961956149565 1081 16451914
SGTC_1263 0774-1208 64.8 µM -2.41723287176382 0.0138056975467803 no 3308 0.00781950413272523 1082 906585
SGTC_2918 7977171 22.06 µM -2.41781510071617 0.0137868748222575 no 3309 0.00780700431349671 1082 2236483
SGTC_1398 3558-0053 112 µM -2.433020176472 0.0133030915535751 no 3310 0.00748673324624006 1091 4532369
SGTC_1492 4158-0558 28.5 µM -2.44754048265737 0.0128548543097622 no 3311 0.00719174829950178 1080 3967268
SGTC_822 1487-0950 154 µM -2.44896482452269 0.0128115971334771 no 3312 0.00716337193683485 1071 1958375
SGTC_2025 5147754 141 µM -2.45500918605855 0.012629428284688 no 3313 0.00704404941451079 1066 315777 YLR208W SEC13
SGTC_1788 fluconazole 20 µM -2.45887845202069 0.0125139944433536 no 3314 0.00696858975232319 1080 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.47063980462037 0.012168703067984 no 3315 0.00674357945455306 1075 3256 An antibiotic and ribosome inhibitor.
SGTC_2115 tiliquinol 12.7705 µM -2.50118310624914 0.011310320148589 no 3316 0.00618895812737576 1083 71208 A bioactive hydroxyquinoline.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.50481112443263 0.011211941885352 no 3317 0.00612583994386212 1074 756377
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -2.51450591995059 0.0109526969740797 no 3318 0.00595996506818501 1082 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_451 chloral hydrate 100 µM -2.52919636838542 0.0105698063634389 no 3319 0.00571620221016539 1088 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1794 st048918 76.9 µM -2.5502541666556 0.0100413138446556 no 3320 0.00538222051744081 1070 672303
SGTC_1009 4106-0057 9.87 µM -2.56754574015145 0.00962473541490987 no 3321 0.00512106379983764 1084 2928005
SGTC_996 3970-0799 1.8 µM -2.5689631294502 0.0095912680929848 no 3322 0.00510016548657207 1062 6615648 YGL040C HEM2
SGTC_1630 st005209 31.3 µM -2.5819578729547 0.0092891482146734 no 3323 0.00491207880815801 1069 3367314
SGTC_2143 5623677 140.463 µM -2.60865680758141 0.00869443801465413 no 3324 0.00454491772994737 1079 5375313
SGTC_1501 4491-0275 38.4 µM -2.66404889851427 0.00756612576286257 no 3325 0.00386031694984671 1091 5104718
SGTC_1562 morin hydrate 59.1 µM -2.67408737023343 0.00737605953461707 no 3326 0.00374664632745934 1081 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3214 9129694 49.47 µM -2.67769179062419 0.00730884813571334 no 3327 0.00370656989125443 1084 17158655
SGTC_669 0108-0021 26.2 µM -2.72999975493429 0.00639249217341013 no 3328 0.00316671863140994 1074 17201
SGTC_739 1486-1183 203 µM -2.73801809582109 0.00626140042865034 no 3329 0.00309053373619271 1091 4346692
SGTC_1620 st003704 16.5 µM -2.74493102098963 0.0061502977464961 no 3330 0.00302618088667358 1086 2834414
SGTC_910 3454-3003 490 µM -2.7477814871378 0.00610499671912067 no 3331 0.00299999906959317 1082 820824
SGTC_1434 4073-0095 163 µM -2.75828587326373 0.00594059771362853 no 3332 0.00290526793964541 1090 24133745
SGTC_3328 9140624 29.0385 µM -2.75869102127095 0.00593433632076996 no 3333 0.00290166883643792 1087 4904392
SGTC_450 aminopyrene 156 nM -2.76128867496577 0.00589432953741393 no 3334 0.00287868812483734 1088 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1379 2144-0755 36.5 µM -2.76494939253851 0.00583835648636542 no 3335 0.00284658137640957 1079 5392327
SGTC_2052 5265182 7.135 µM -2.84681281275925 0.00470387633651066 no 3336 0.00220796599971113 1089 1239884
SGTC_1183 1254-0324 198 µM -2.86124146451121 0.00452569338699431 no 3337 0.00210992760273508 1084 5799357
SGTC_1081 sertraline 6 µM -2.88468732658819 0.00424898136004918 no 3338 0.00195901291488533 1084 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2491 paeonol 100 µM -2.9112311308496 0.00395404690645794 no 3339 0.00180003799844482 1090 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3313 9133968 57.047 µM -2.93021225399224 0.0037545291910485 no 3340 0.00169365272569843 1080 1494643
SGTC_1136 pergolide 1.05886 µM -2.9549905664301 0.00350767592519477 no 3341 0.00156339305785914 1088 47811 A dopamine receptor agonist.
SGTC_2176 5809774 33.9695 µM -3.15455406978975 0.00199343595026066 no 3342 0.000803717947496797 1091 2870539
SGTC_2309 7664088 163.95 µM -3.19833369349653 0.00175373773110635 no 3343 0.000691121167963721 1085 704922
SGTC_2953 9074162 66.49 µM -3.20149425756176 0.00173749235049989 no 3344 0.000683584000983862 1086 16451992
SGTC_3314 9135860 59.4275 µM -3.20913783956212 0.00169876873998321 no 3345 0.000665668251636622 1083 25252478
SGTC_2946 9065502 71.43 µM -3.22788519657257 0.00160709624192505 no 3346 0.000623545063340232 1079 16489101
SGTC_1691 st019933 84.6 µM -3.2698030831746 0.00141821345343249 no 3347 0.000538111876273099 1093 6176082
SGTC_2886 9058944 51.95 µM -3.36819854228541 0.00105180458938579 no 3348 0.000378305444098612 1093 4949929
SGTC_2976 9009005 19.48 µM -3.43046559316641 0.000867136242624208 yes 3349 0.000301273191352587 1089 2993148
SGTC_3329 9141233 27.5565 µM -3.46232332893486 0.000784651580214441 yes 3350 0.00026776668909619 1086 4909101 YNL103W MET4
SGTC_2999 9069765 71.4286 µM -3.47635441843109 0.000750667591100674 yes 3351 0.000254140048971008 1090 2097066
SGTC_884 0851-0618 334 µM -3.71048983176744 0.000350450693144879 yes 3352 0.00010342930284912 1092 9642473
SGTC_2898 9056270 58.44 µM -3.80641326800507 0.000253312850548394 yes 3353 7.049835321768e-05 1093 19154699
SGTC_1499 4480-0877 67.3 µM -3.8531319674241 0.000215700726101137 yes 3354 5.83082479350215e-05 1095 2861909
SGTC_2439 5492030 7.2 µM -3.92566544992551 0.000167487521461599 yes 3355 4.32451482359392e-05 1094 5722370
SGTC_2948 9070189 9.45 µM -4.40675429173558 2.8127310218424e-05 yes 3356 5.24655516820024e-06 1090 6473636 YDL196W YDL196W