SGTCid condition conc unit HEM15|YOR176W.score HEM15|YOR176W.strain.pval HEM15|YOR176W.strain.significant HEM15|YOR176W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1310 1188-0297 994 nM 9.69211985350862 8.33741783183243e-22 yes 1 1.62848603691501e-22 2 1588352 SGTC_547 1120-0019 610 nM 6.32984195088473 2.71016691428611e-10 yes 2 1.22706222283577e-10 2 3676939 SGTC_2018 5133068 143 µM 6.21265624862037 5.61738782968636e-10 yes 3 2.60481673375185e-10 3 785362 SGTC_1626 st003712 1.76 µM 5.98495519589602 2.23040564488399e-09 yes 4 1.08224717493803e-09 4 24207035 SGTC_288 1315-0019 35.1 µM 5.24808120264318 1.3805132153046e-07 yes 5 7.68457780646756e-08 10 6811474 SGTC_348 k064-0012 10.7 µM 4.42092522633238 7.69861381815075e-06 yes 6 4.91395902820582e-06 1 5066323 SGTC_1608 st001473 40.5 µM 4.3432479468201 1.08672235506813e-05 yes 7 7.01957658704834e-06 3 7292267 SGTC_1044 1222-0021 1.78 µM 4.11283322100452 2.92305115449237e-05 yes 8 1.95416372084065e-05 33 4306703 SGTC_1473 k844-0725 134 µM 3.92024746054724 6.43542527035266e-05 yes 9 4.42290447600204e-05 5 54682906 SGTC_771 0250-0039 27.3 µM 3.77340755504943 0.000114786609879387 yes 10 8.05164528056101e-05 3 3005115 SGTC_3005 9076496 71.4286 µM 3.7557128431624 0.000122911329958857 yes 11 8.64243954847096e-05 1 21368410 SGTC_902 1120-0002 2.07 µM 3.73528695703223 0.000132960013848128 yes 12 9.37506286926557e-05 21 3280475 SGTC_1905 st060207 84.5 µM 3.73123575720693 0.00013504243651827 yes 13 9.52714013043885e-05 4 1948547 SGTC_6 0844-0013 19.835 µM 3.634083723778 0.00019514526722938 yes 14 0.000139485134740071 12 1584900 SGTC_1555 citronellol 128 µM 3.61974644115062 0.000205889559574436 yes 15 0.000147445920099499 3 8842 A terpine precursor. SGTC_157 1348-1695 65.819 µM 3.60736408107582 0.00021561095954754 yes 16 0.000154661740166379 39 5380510 SGTC_2023 5144124 124 µM 3.59032648518859 0.000229689016883595 yes 17 0.000165132012485016 9 2830192 SGTC_311 1315-0136 58 µM 3.44889497429444 0.000384329348562632 yes 18 0.000281442793885712 9 6759207 SGTC_995 3931-2021 34.6 µM 3.42637453484764 0.000416454666073212 yes 19 0.000305848141819898 11 730143 SGTC_2039 Aminomethylbenzodioxan 200 µM 3.36851702711714 0.000510757394780373 yes 20 0.000377868644477763 4 15053 SGTC_399 oxolinic acid 75 µM 3.32709779061948 0.000590011276553532 yes 21 0.000438777857325199 6 4628 A DNA gyrase inhibitor. SGTC_13 0199-0087 65 µM 3.22441959679974 0.000837974905621826 yes 22 0.000631141486676127 11 4589825 SGTC_2294 7971431 200 µM 3.20049406819502 0.000908107443789336 yes 23 0.000685960966461117 9 5741572 SGTC_2607 solasodine 47.35 µM 3.15833053652474 0.00104496635806155 no 24 0.000793377667872071 26 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_757 1066-0008 322 µM 3.12166245240607 0.00117910358950993 no 25 0.000899164996138758 10 6842497 SGTC_2992 9074591 71.4286 µM 3.11017821070374 0.00122424987800136 no 26 0.000934872492761252 9 17741321 SGTC_271 rotenone 740 µM 3.0897226257494 0.00130860081478468 no 27 0.0010017174920014 5 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1266 0828-0227 32.9 µM 3.07870884057794 0.00135618677375393 no 28 0.00103949878593444 23 3913820 SGTC_3008 9078912 71.4286 µM 3.0360461736719 0.00155581439467017 no 29 0.00119851326788207 10 16648731 SGTC_1821 st053465 65.6 µM 2.92920114623295 0.00217863827527852 no 30 0.00169917214643445 9 675086 SGTC_2857 9024691 58.44 µM 2.92584601286943 0.00220142850673338 no 31 0.0017176046326394 12 16478292 SGTC_1287 0971-0001 34.6 µM 2.9058301058767 0.00234193675244669 no 32 0.00183140132853419 17 4665869 SGTC_2854 9024559 71.43 µM 2.88466485646632 0.00249930052334656 no 33 0.00195915273059264 24 3163529 SGTC_541 4513-1321 94 µM 2.87697928215707 0.00255876844113122 no 34 0.00200750977550943 26 747515 SGTC_2138 5575593 77.673 µM 2.8767187409243 0.00256080663307018 no 35 0.00200916790889251 6 762213 SGTC_2990 9074105 71.4286 µM 2.86872198927979 0.00262408262052557 no 36 0.0020606693781607 12 6502001 SGTC_528 3492-0019 172 µM 2.82309694259934 0.00301288459135286 no 37 0.00237810938412399 45 2869262 SGTC_441 propafenone 146 µM 2.81215603666486 0.00311351664506571 no 38 0.00246053122327645 11 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1607 st000305 50.6 µM 2.74645486649894 0.00378405095744449 no 39 0.00301215871752134 15 5457690 SGTC_322 k048-0136 19.3 µM 2.74467576167328 0.00380388504367603 no 40 0.00302853548137486 22 6823282 SGTC_947 3447-0010 211 µM 2.7220779542036 0.00406404727482595 no 41 0.00324364188273796 20 748350 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.64682573402518 0.00504905040979503 no 42 0.0040625605915207 32 16725076 SGTC_1006 4099-6547 255 µM 2.64092982981146 0.00513454056801824 no 43 0.00413394207264743 21 3146833 SGTC_999 SEC7.066 22.7 µM 2.62477983322395 0.00537534897282843 no 44 0.00433525061471551 31 740511 YDR170C SEC7 SGTC_2448 5185112 27.17 µM 2.61958790271969 0.00545486981382582 no 45 0.00440180402721677 21 5718189 SGTC_1781 st038725 66.3 µM 2.61392303128386 0.00554282545712834 no 46 0.00447545992197251 37 4270275 YIL048W NEO1 SGTC_309 k408-0051 1.48 µM 2.59303132177961 0.00587818985410005 no 47 0.00475670530088391 58 3640463 SGTC_2796 7949634 45.45 µM 2.55227073681434 0.00658468628096015 no 48 0.00535116595433668 28 2971588 SGTC_1539 benzyladenosine 56 µM 2.54181018059569 0.00677769192518959 no 49 0.00551400232703632 23 92208 A nucleotide analog. SGTC_374 0880-0231 82.3 µM 2.53416091627868 0.00692197399329034 no 50 0.00563584786557834 37 6833587 SGTC_444 curcumin 90.4 µM 2.47575002511003 0.00811606105315289 no 51 0.00664783159036169 48 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2040 5100729 123 µM 2.39600701504215 0.0100367024274847 no 52 0.00828738654800414 31 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_530 4358-1714 28 µM 2.39219407661734 0.0101377343098075 no 53 0.00837399184953803 47 1564641 SGTC_2762 leflunomide 42.06 µM 2.39200074215872 0.0101428806680303 no 54 0.00837840424663611 34 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_689 0833-0039 98 µM 2.38467151584309 0.0103396652563554 no 55 0.00854718870423572 29 5374726 SGTC_431 k089-0097 107 µM 2.38244607079162 0.0104000719830247 no 56 0.00859902540306174 45 5499420 SGTC_1516 st013856 110 µM 2.38123984116436 0.0104329418500755 no 57 0.00862723687156634 28 5281404 A mutagen and neurotoxin. SGTC_1819 st053448 58.6 µM 2.37352150468314 0.010645418312384 no 58 0.00880968350666666 29 2857616 SGTC_1816 st051957 91.6 µM 2.36029131194277 0.0110184034487494 no 59 0.00913029461371863 17 674121 SGTC_590 k048-0076 22.4 µM 2.35526031683755 0.0111631921258755 no 60 0.00925486687469988 39 6832814 SGTC_1605 st000082 49.1 µM 2.3531451705666 0.0112245568620796 no 61 0.00930768245783084 30 1114022 SGTC_3206 9114350 49.47 µM 2.34921170251738 0.0113394548878392 no 62 0.00940660341676774 27 17087243 SGTC_2811 7967822 32.47 µM 2.34527187367165 0.0114555618863363 no 63 0.00950660489204744 32 2232244 SGTC_3220 9131269 49.47 µM 2.32591860297246 0.0120410201263383 no 64 0.0100114467077904 23 17722206 SGTC_1914 st062367 72.6 µM 2.32580256159535 0.0120446073371782 no 65 0.0100145429666769 36 978205 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.30555731875816 0.0126848065064452 no 66 0.0105676902465002 61 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1740 st038286 13.222 µM 2.29759842018562 0.012944432950663 no 67 0.0107923278298735 42 716786 SGTC_397 arbidol 50 µM 2.29102522726545 0.0131623085710805 no 68 0.0109809773209953 32 131410 A RNA synthesis inhibitor. SGTC_353 1988-1175 58.3 µM 2.26990730448566 0.0138838631207652 no 69 0.011606603917819 52 2788357 SGTC_2979 9012552 45.46 µM 2.26749445055383 0.0139684370336695 no 70 0.0116800187630948 24 17100905 SGTC_2984 9022109 38.96 µM 2.26554823443828 0.0140369778734754 no 71 0.011739528796953 33 6459207 SGTC_2484 5809818 12.04 µM 2.24939297866231 0.0146171990615712 no 72 0.0122437524629406 33 2870548 SGTC_113 0099-0221 2.5 µM 2.24491175653396 0.0147817548129696 no 73 0.0123868990312226 36 89219 SGTC_332 4112-0506 40.9 µM 2.22251573766282 0.0156282476848982 no 74 0.0131242358353348 71 2790355 SGTC_3245 9134821 49.47 µM 2.21190532670357 0.0160435946721565 no 75 0.0134866035665123 46 17014901 SGTC_305 1682-2595 20.8 µM 2.20637762987745 0.016263701287152 no 76 0.0136787850000244 35 226033 SGTC_2449 5812982 45.77 µM 2.17092922850999 0.0177375921264322 no 77 0.0149682612547408 28 776185 SGTC_1025 k007-0731 70 µM 2.1666333032507 0.0179237243725027 no 78 0.0151314129580923 34 6256118 SGTC_2795 7780010 54.55 µM 2.16419726368567 0.0180300103973351 no 79 0.0152246066069914 42 953673 SGTC_412 gemfibrozil 100 µM 2.15828658248105 0.0182901331546114 no 80 0.0154527786347723 46 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1560 lithocholic acid 53.1 µM 2.14213905045006 0.0190171220879223 no 81 0.0160911471682254 25 9903 A bile acid which acts as a detergent. SGTC_307 1501-1223 22.3 µM 2.13455414089859 0.0193670021261774 no 82 0.0163987233849991 37 2830329 SGTC_3241 9133421 49.47 µM 2.13329918938636 0.0194254152326505 no 83 0.0164500953404122 14 17018221 SGTC_481 bay k-8644 50 µM 2.12669661925394 0.0197352101721677 no 84 0.0167226493026991 37 2303 A calcium channel antagonist. SGTC_1651 st011928 86.1 µM 2.11856944672663 0.0201222892427735 no 85 0.0170634350516297 44 720198 SGTC_479 n-linoleoylglycine 10 µM 2.11772012606354 0.0201631095906107 no 86 0.0170993886694388 39 6433346 An anti-infammatory. SGTC_1185 1319-0113 81.3 µM 2.10325273775048 0.0208693044418568 no 87 0.0177218412278502 41 4672763 SGTC_1648 st011736 69.8 µM 2.09680065442052 0.0211909369540887 no 88 0.0180056128235816 40 2855514 SGTC_2956 9076196 2.52 µM 2.08564650565607 0.0217568545837574 no 89 0.018505327713964 38 16423868 SGTC_555 4296-0685 37 µM 2.07339412797783 0.0223931533175701 no 90 0.0190678074902039 51 2908540 YHR072W ERG7 SGTC_1042 0350-0096 82 µM 2.05807926281004 0.0232104992470352 no 91 0.0197912626476942 47 3122515 SGTC_523 1934-0222 13.7 µM 2.05725667406925 0.023255101967909 no 92 0.0198307712801873 59 1361595 SGTC_263 alizarin 107.927 µM 2.04304236256862 0.0240373019817097 no 93 0.0205241223717767 70 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_231 b-estradiol 524 µM 2.03324158692964 0.0245894091375165 no 94 0.0210140607104694 41 450 A steroid. SGTC_1476 4112-3294 3.34 µM 2.03265934952337 0.0246225404875561 no 95 0.0210434754527571 36 704369 SGTC_2621 lithochol-11-enic acid 100 µM 2.02389427566063 0.0251258471432381 no 96 0.0214905155281663 50 6708711 SGTC_1728 st035614 33.7865 µM 2.00887663264376 0.0260082248054074 no 97 0.0222751093159386 59 15945546 SGTC_2343 7990716 14.84 µM 2.00886092820519 0.0260091609313489 no 98 0.0222759422739557 52 6456862 SGTC_1734 st037168 69.4 µM 2.00500092185003 0.0262401084302028 no 99 0.0224814742424827 53 708907 SGTC_741 4582-0002 126 µM 2.00488149534444 0.026247281076257 no 100 0.0224878587094871 39 2912688 SGTC_820 1582-0060 59.9 µM 2.00275159623187 0.0263754763987822 no 101 0.0226019788268483 56 3848840 SGTC_2291 7917025 104.35 µM 2.00077998959215 0.0264946103539617 no 102 0.0227080523906476 49 2964612 SGTC_2446 5162541 200 µM 1.99915075981732 0.0265933952371861 no 103 0.0227960222017455 36 1549321 SGTC_2273 7815444 169.05 µM 1.99075971417428 0.0271070540279327 no 104 0.0232536551461636 61 2824616 SGTC_2428 5615643 7.78 µM 1.98726141465013 0.027323634797119 no 105 0.0234467176017634 73 2253075 SGTC_383 2324-0395 7.37 µM 1.98577609597121 0.0274160268241881 no 106 0.0235290955664122 35 3146421 SGTC_602 3130-1533 38.1 µM 1.98200751474084 0.0276516153844764 no 107 0.0237391997950761 68 720941 SGTC_3088 9117578 49.47 µM 1.96785153303657 0.0285516833233432 no 108 0.0245425613920586 55 678341 SGTC_1206 3978-0017 132 µM 1.96750287762623 0.0285741555143352 no 109 0.0245626322470159 64 3873677 SGTC_3204 9114183 49.47 µM 1.96150183416684 0.0289632574249509 no 110 0.024910255625158 62 17027248 SGTC_3353 9151644 39.2805 µM 1.9528675195672 0.0295308154350785 no 111 0.0254176476566421 53 4909158 SGTC_2253 7938677 135.83 µM 1.93960339154215 0.0304206662746202 no 112 0.0262139541936574 42 2301972 SGTC_1887 st057648 70.8 µM 1.93901677354108 0.030460528223382 no 113 0.0262496478704145 66 688672 SGTC_3203 9113543 49.47 µM 1.93589084325666 0.0306736721909309 no 114 0.026440535736484 67 17018012 SGTC_3191 9110352 49.47 µM 1.92507421018601 0.0314207640614734 no 115 0.027110037429636 39 17122424 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.91223952971482 0.0323266914853813 no 116 0.0279227390043611 36 140250 A respiratory chain inhibitor. SGTC_703 3875-0075 71.8 µM 1.90576841494406 0.0327915611494725 no 117 0.0283401292681207 65 2850814 SGTC_390 dec-rvkr-cmk 16.7 µM 1.90453477625961 0.0328808053577842 no 118 0.0284202859861489 68 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3227 9130768 49.47 µM 1.89996291734618 0.0332132914083537 no 119 0.0287189931102659 38 17720899 SGTC_2853 9015042 58.44 µM 1.89533426286945 0.0335527241093712 no 120 0.0290240658374682 41 6457456 SGTC_174 3553-0389 74.3 µM 1.89234794490367 0.0337732311295186 no 121 0.0292223184072034 62 738071 SGTC_3211 9128781 49.47 µM 1.89170459600934 0.0338208911955274 no 122 0.0292651753213177 73 17194361 SGTC_1033 k072-0102 21.3 µM 1.88825561006973 0.0340773405632988 no 123 0.0294958217400273 52 5965931 SGTC_1780 st038448 24.544 µM 1.88455938865784 0.0343539458660687 no 124 0.0297446748078429 60 728868 YDL195W SEC31 SGTC_1733 st037357 54.9 µM 1.87276233789913 0.0352491396238947 no 125 0.0305506054265091 64 1272339 YGL099W LSG1 SGTC_369 0957-0393 4.5 µM 1.86197976259409 0.036084004969563 no 126 0.0313029714265625 70 6997992 SGTC_472 calcifediol 10 µM 1.86027399981934 0.0362175491958054 no 127 0.0314233850642648 35 5283731 A vitamin D metabolite. SGTC_2155 5570423 76 µM 1.86026148396346 0.036218530555944 no 128 0.0314242699999948 56 797402 SGTC_724 3910-0327 137 µM 1.8582220934899 0.0363787288653331 no 129 0.0315687409042719 72 2885483 SGTC_169 k015-0017 16.025 µM 1.85817802857867 0.0363821966448917 no 130 0.031571868521781 51 1840002 SGTC_2394 5221648 200 µM 1.85496535851693 0.036635754217857 no 131 0.0318005867857404 70 788586 SGTC_2404 5161160 200 µM 1.85360806889561 0.036743310771516 no 132 0.031897626188531 82 2831543 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.85008117801211 0.0370240022190734 no 133 0.0321509251516376 62 442882 SGTC_3256 9138902 49.47 µM 1.84447978144203 0.0374733957926367 no 134 0.0325566248669025 40 17228773 SGTC_34 0469-0683 81.75 µM 1.8420316781985 0.0376711983363598 no 135 0.0327352581559908 56 3690923 SGTC_2813 7971799 71.43 µM 1.84180054666672 0.0376899173210093 no 136 0.0327521650410616 74 2234054 SGTC_75 0159-0059 199.013 µM 1.83270671867972 0.0384324596004122 no 137 0.0334230988025028 81 5377270 SGTC_420 mitomycin C 81.9 mM 1.82164444669635 0.0393517619982594 no 138 0.0342544761359121 79 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1782 st039423 80.636 µM 1.8215366106222 0.0393608107363041 no 139 0.0342626633827743 46 2068169 SGTC_1502 4534-4282 27.7 µM 1.81859266525425 0.0396084976961015 no 140 0.0344867988383286 47 3278949 SGTC_423 5-fluorouracil 457 µM 1.81754713092552 0.0396967674967398 no 141 0.0345666892504995 98 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2395 5646831 180.19 µM 1.80879953464948 0.0404415716490677 no 142 0.0352410763133818 66 6808628 SGTC_3161 9100388 49.47 µM 1.8029013101273 0.0409501441713484 no 143 0.0357018576131629 63 25236368 SGTC_128 0906-2981 13.371 µM 1.79433119666964 0.0416983319585632 no 144 0.036380160784593 84 6740226 SGTC_2587 piperic acid 92.2 µM 1.78922285390988 0.042149542058687 no 145 0.0367894662487799 53 5370536 SGTC_3023 9089636 49.47 µM 1.78573224445469 0.0424601272337689 no 146 0.0370713109503862 56 17249241 SGTC_3228 9131799 49.47 µM 1.78557659698909 0.0424740193260423 no 147 0.0370839194886946 71 17015818 SGTC_339 3091-4833 71.4 µM 1.78419308218305 0.0425976645869308 no 148 0.0371961480139844 100 3240077 SGTC_1747 st037496 66.6 µM 1.78190867405871 0.0428024599069716 no 149 0.0373820628999967 88 723305 SGTC_1928 4'-methoxychalcone 40.3 µM 1.77295237104692 0.0436130734398632 no 150 0.0381182997418325 72 641818 SGTC_1752 st044819 83.042 µM 1.7683132402645 0.0440377951481234 no 151 0.0385042758267993 75 441209 YML126C ERG13 SGTC_1380 2291-0730 164 µM 1.75966552243177 0.0448384104543531 no 152 0.0392322674260163 62 2999191 SGTC_488 nitrendipine 139 µM 1.75906164760949 0.044894752779138 no 153 0.0392835191017675 48 4507 Dihydropyridine L-type calcium channel blocker. SGTC_171 k064-0041 9.68 µM 1.75548809528625 0.0452293375569581 no 154 0.0395879275926624 78 53325 SGTC_260 nsc-65238 3.989 µM 1.75377621365692 0.0453903269089262 no 155 0.0397344301866108 65 3246252 SGTC_3239 9133757 49.47 µM 1.74709666227146 0.0460228999353148 no 156 0.0403102861400455 44 17036923 SGTC_1366 1683-0113 21.9 µM 1.7459363002398 0.046133508214334 no 157 0.0404110106336783 58 708623 SGTC_387 norethindrone acetate 66.7 µM 1.74330981985743 0.0463846587633243 no 158 0.0406397554892615 66 541197 SGTC_1731 st035964 63 µM 1.74058482017159 0.0466463889332047 no 159 0.0408781901837537 89 6739575 SGTC_3221 9128209 49.47 µM 1.7345523181775 0.0472300130407204 no 160 0.0414100656575709 65 16460723 SGTC_1623 st003709 20.3 µM 1.72933896125386 0.0477390893012557 no 161 0.0418742237136178 70 16192618 SGTC_1149 3909-7961 23.3 µM 1.72777720813167 0.047892444459565 no 162 0.0420140875578622 69 735261 SGTC_2417 cerulenin 830 nM 1.72750375544677 0.0479193364646287 no 163 0.0420386156545535 76 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2846 9008642 19.48 µM 1.72559080205216 0.04810779918148 no 164 0.0422105276381644 85 2992898 SGTC_3141 9094609 49.47 µM 1.72423937486895 0.0482412979344753 no 165 0.0423323193215059 91 25236309 YDL196W YDL196W SGTC_3229 9132204 49.47 µM 1.71704412654021 0.0489570670145634 no 166 0.0429855548896519 47 17682924 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.71544326424452 0.0491174658985472 no 167 0.0431319945049784 90 65057 A dermal irritant. YDR527W RBA50 SGTC_1413 3910-0535 34.4 µM 1.71526458766577 0.0491353944614944 no 168 0.0431483639955727 73 2876951 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.71338642569838 0.0493241672563155 no 169 0.0433207359523018 90 5282362 SGTC_1264 0783-0040 158 µM 1.70982502371686 0.0496837110851886 no 170 0.0436491171000234 64 2855798 SGTC_3057 9095946 49.47 µM 1.70774741549116 0.0498944213522636 no 171 0.0438416099980195 82 24540043 SGTC_2987 9018338 71.43 µM 1.70690943397622 0.0499796105860664 no 172 0.043919443533807 93 5055682 SGTC_2962 9082311 13.18 µM 1.7068272223876 0.0499879744635522 no 173 0.0439270855234629 91 16459453 SGTC_3092 9117248 49.47 µM 1.69942466078532 0.0507456676071877 no 174 0.0446195993484288 59 17141857 SGTC_1412 3909-8563 178 µM 1.69589846127648 0.051109795422587 no 175 0.0449525555643178 68 23767530 SGTC_1289 0976-0073 69.1 µM 1.69333919272772 0.0513753744031439 no 176 0.045195461012794 72 3391136 SGTC_50 0929-0078 56.389 µM 1.684537105227 0.0522971679841007 no 177 0.0460389573839288 58 1377751 SGTC_360 0957-0399 1.01 µM 1.68115137474896 0.0526552149887519 no 178 0.0463667577995992 89 6752301 YPR165W RHO1 SGTC_1953 st076800 12.1 µM 1.67665846926673 0.0531333480168061 no 179 0.0468046430979233 102 297591 SGTC_482 fipronil 114 µM 1.6725327141722 0.0535754348800385 no 180 0.0472096612490885 43 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2597 laccaic acid a 100 µM 1.67197502678598 0.053635415658271 no 181 0.0472646233323394 84 5491415 A textile dye. SGTC_1163 k060-0048 49.9 µM 1.67039043622994 0.0538061329580336 no 182 0.0474210703053556 72 6809982 SGTC_1604 st002052 72.4 µM 1.66622109643265 0.0542573765081439 no 183 0.0478346927853315 63 6254834 YHR062C RPP1 SGTC_2349 9023730 187.07 µM 1.66034150708215 0.0548988012339181 no 184 0.0484228850451743 62 4126287 SGTC_2222 6885208 172.143 µM 1.65363258821957 0.055638004710608 no 185 0.0491010935677816 55 609514 SGTC_302 1094-0063 18.9 µM 1.65200628267548 0.0558183723646196 no 186 0.049266635047888 109 5440289 SGTC_1011 4112-3381 17.4 µM 1.65098157034398 0.0559322562119554 no 187 0.0493711690761513 79 2877139 SGTC_3356 9151811 4.48 µM 1.65068390518 0.055965372271673 no 188 0.0494015679740099 80 1859254 YPR165W RHO1 SGTC_2971 9092186 9.93 µM 1.64345485305141 0.0567743825745081 no 189 0.0501444294812505 86 25236400 SGTC_162 k030-0015 37.8 µM 1.64251000617547 0.0568807985445677 no 190 0.0502421770939751 83 1809920 YMR134W ERG29 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.64170931125871 0.0569711019081963 no 191 0.0503251305303678 95 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3222 9128301 49.47 µM 1.63352395363625 0.0579007447390249 no 192 0.0511794235297904 98 4911358 SGTC_2424 5537928 59.2 µM 1.63264767378778 0.0580009698060618 no 193 0.051271559220023 89 5382802 SGTC_3051 9093778 49.47 µM 1.63167934847467 0.0581118811595553 no 194 0.051373526376525 88 17217378 SGTC_649 1123-0311 367 µM 1.6254135345517 0.0588335964035393 no 195 0.0520372369613072 89 693629 YIL048W NEO1 SGTC_52 0329-0193 875 nM 1.62411447397486 0.0589841027474744 no 196 0.0521756897229601 77 3739292 SGTC_2326 6164455 177.58 µM 1.62288957577052 0.0591262933280735 no 197 0.0523065061706131 97 2888790 SGTC_475 α-linolenic acid 10 µM 1.61606156831843 0.0599238450779792 no 198 0.0530405011805099 97 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1444 4112-3581 28 µM 1.61217246566648 0.0603818674614598 no 199 0.0534622075797571 80 2877249 SGTC_1943 st076331 65.2 µM 1.61002088404306 0.0606364353051997 no 200 0.0536966485936125 72 24208415 SGTC_2016 5121758 140 µM 1.60929174929966 0.0607228942565244 no 201 0.0537762811748601 115 2795203 SGTC_3352 9151559 45.5865 µM 1.60764971687393 0.0609179553484969 no 202 0.0539559585052017 72 17159339 SGTC_773 4358-1457 44.6 µM 1.60396369257873 0.0613576112822273 no 203 0.0543610279428593 106 1186886 SGTC_191 3914-0123 66.505 µM 1.60267499687792 0.0615119058360594 no 204 0.0545032132257428 93 3144412 SGTC_2317 5986382 200 µM 1.59984072603946 0.0618523169410006 no 205 0.0548169607514097 90 877883 SGTC_1311 1190-0148 100 µM 1.59781805526615 0.0620961483415298 no 206 0.0550417375950481 94 1961333 SGTC_2589 lobaric acid 100 µM 1.59760657864066 0.0621216849283224 no 207 0.0550652807147422 71 73157 A novel microtubule depolymerizer. SGTC_1594 piperine 70.1 µM 1.59302653299882 0.0626767549695334 no 208 0.0555771194489095 70 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2903 5923464 63.88 µM 1.59296822343491 0.0626838465258482 no 209 0.0555836599074085 77 2876576 SGTC_1204 4049-0315 18.3 µM 1.59194925831187 0.0628078731151869 no 210 0.0556980531396567 77 588402 SGTC_764 1951-2361 146 µM 1.58914770058144 0.0631498593273471 no 211 0.0560135253535809 120 5438930 SGTC_982 1491-0518 27.5 µM 1.58181707660174 0.0640515707524427 no 212 0.0568456677469311 72 3091256 SGTC_3198 9112019 49.47 µM 1.58149329123924 0.0640916279800614 no 213 0.0568826458433182 95 45595555 SGTC_2228 7354201 200 µM 1.57701092879811 0.0646481682665562 no 214 0.057396505209338 95 753451 SGTC_3120 9124077 49.47 µM 1.57384653463106 0.0650433216569176 no 215 0.0577614664436574 71 18774327 YGL155W CDC43 SGTC_2270 7924575 90.91 µM 1.57308459237165 0.0651387485792761 no 216 0.0578496160409583 91 1262135 SGTC_184 1494-0393 24.714 µM 1.57294304044756 0.0651564887394371 no 217 0.0578660039177134 132 3090647 SGTC_1112 tnp00069 1.16933 µM 1.56883772203026 0.0656726253692071 no 218 0.0583428781487665 78 145826 SGTC_3247 9135149 49.47 µM 1.55833024766664 0.0670081048543359 no 219 0.0595774911016122 125 8934436 YOR116C RPO31 SGTC_1241 0364-0022 50.8 µM 1.55124982567784 0.0679197933417617 no 220 0.060420912899508 88 4563895 SGTC_1428 4049-0204 61.7 µM 1.55066293827294 0.0679957898767863 no 221 0.0604912403095972 91 X1428 SGTC_621 3584-0052 32.1 µM 1.54611172759227 0.0685873604581737 no 222 0.0610387934771975 92 2273927 SGTC_3217 9129673 49.47 µM 1.54376469191371 0.0688939777701315 no 223 0.0613226739123805 93 17248312 SGTC_818 4072-2707 53.5 µM 1.54346731643497 0.0689329022802718 no 224 0.0613587158021323 82 882871 SGTC_2942 9052777 62.25 µM 1.5425526152294 0.0690527369711909 no 225 0.0614696812750652 108 6469503 SGTC_1824 st053723 68.6 µM 1.5368333803017 0.0698056554181745 no 226 0.0621670584414899 80 675225 SGTC_347 4534-1311 26.2 µM 1.53636340312091 0.069867806220379 no 227 0.0622246386158114 86 2862016 SGTC_1842 st055362 61.2 µM 1.5336204249971 0.0702313934996793 no 228 0.0625615302503712 74 676032 SGTC_3223 9129970 49.47 µM 1.52931519985041 0.0708049918148024 no 229 0.0630931616492537 93 17248386 SGTC_2961 9083290 32.55 µM 1.52708885741884 0.0711030227233006 no 230 0.0633694586495341 82 17741490 SGTC_2242 6630449 61.2675 µM 1.52534062063134 0.0713377261628595 no 231 0.0635870805009985 83 691249 YDR170C SEC7 SGTC_1667 st014849 34.6 µM 1.52426474273623 0.0714824597203019 no 232 0.0637212953914525 87 5348460 SGTC_300 r073-0011 5.04 µM 1.52244093089106 0.0717283244778719 no 233 0.0639493177589867 87 2735780 SGTC_1964 st076914 61 µM 1.52183150953917 0.0718106238921395 no 234 0.0640256520342298 113 24208661 SGTC_2261 9010538 184.68 µM 1.51764003997753 0.0723786249172308 no 235 0.0645525836058707 91 6457250 SGTC_1437 4092-1038 11.6 µM 1.51648382427001 0.072535912009537 no 236 0.0646985287340052 98 3977136 SGTC_1077 5-fluorocytosine 377 nM 1.51284847058214 0.0730321573568259 no 237 0.0651590767392923 118 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3192 9110362 49.47 µM 1.51231962468764 0.0731045636356123 no 238 0.0652262854797827 85 16649480 SGTC_1550 gossypolone 36.6 µM 1.51199532582637 0.0731489917749852 no 239 0.065267525817962 95 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_918 glabranin 770.725 nM 1.51099651962547 0.0732859555529309 no 240 0.0653946688036526 91 124049 Also referred to as licorice root. SGTC_2776 terbinafine 19.92 µM 1.50706040273167 0.0738276158250474 no 241 0.0658975876406879 100 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1275 0867-0008 21.1 µM 1.50609573641983 0.0739608319762411 no 242 0.066021299485216 83 3422836 SGTC_1213 1315-0166 115 µM 1.49861319683995 0.0750003826008859 no 243 0.0669870035701683 111 768401 SGTC_1490 4089-0339 670 nM 1.49602204936471 0.0753629572329882 no 244 0.0673239546914833 95 742542 SGTC_3079 9117512 49.47 µM 1.49032855879443 0.0761643283364081 no 245 0.0680689334300916 102 7185044 SGTC_1094 duloxetine 25.4 µM 1.48999104086777 0.0762120375862237 no 246 0.0681132958176341 87 60834 A selective serotonin reuptake inhibitor. SGTC_1308 1187-1617 41.4 µM 1.4896726254028 0.0762570674889076 no 247 0.0681551678889983 107 2882570 SGTC_2656 pseudo-anisatin 100 µM 1.48619737655316 0.0767498499591306 no 248 0.0686134606339104 71 6708809 A neurotoxin. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.47908483428803 0.0777659363485814 no 249 0.0695588214678826 91 115019 SGTC_3036 9090181 49.47 µM 1.47854809960261 0.0778430257814252 no 250 0.0696305663350171 96 25236586 SGTC_3046 9092212 49.47 µM 1.47643876521123 0.0781465444249324 no 251 0.0699130712608711 86 25236637 SGTC_1471 k673-0312 37 µM 1.47082870693973 0.0789581612547417 no 252 0.0706687234436868 89 24099884 SGTC_553 k007-0256 45.7 µM 1.47020378506965 0.0790489635664116 no 253 0.070753284945766 111 6287000 SGTC_1425 4048-4433 7.33 µM 1.46983987024489 0.0791018774921695 no 254 0.070802564004991 117 23734946 SGTC_906 1165-0455 526 µM 1.46714274806822 0.0794948806956272 no 255 0.0711686136908331 94 3252859 SGTC_2790 5423970 71.43 µM 1.46686429453054 0.0795355387336715 no 256 0.0712064876210997 114 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_364 0083-0097 67.7 µM 1.46647779666278 0.0795919988025919 no 257 0.0712590828729776 100 5207356 SGTC_688 0527-0193 473 µM 1.46532704852875 0.0797602810194226 no 258 0.0714158551260896 91 4007154 SGTC_722 3534-0461 190 µM 1.46385719811476 0.0799756191199161 no 259 0.0716164851312534 78 658262 SGTC_3022 9087993 49.47 µM 1.46057511758822 0.080458041418059 no 260 0.0720660394722161 94 17173644 SGTC_3196 9111891 49.47 µM 1.45264936162316 0.0816320834225543 no 261 0.0731605666836085 105 18891510 SGTC_2673 kobusone 100 µM 1.4509985628003 0.0818782334399455 no 262 0.0733901302040576 93 6710676 An epoxy ketone and protein crosslinker. SGTC_3138 9097216 49.47 µM 1.45062891021172 0.0819334287771215 no 263 0.0734416102790182 108 25237486 SGTC_228 caffeine 993.056 µM 1.44971051474613 0.082070681998796 no 264 0.0735696311744713 60 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2244 6635614 200 µM 1.44834081681176 0.0822757036067692 no 265 0.0737608788601044 65 836499 SGTC_962 1254-0300 21.5 µM 1.44765977644272 0.0823777877881791 no 266 0.0738561122526113 95 7340576 SGTC_2512 diallyl trisulfide 49.23 µM 1.44671256903833 0.0825199274639448 no 267 0.0739887213495358 116 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1005 4092-0690 4.4 µM 1.44456131883551 0.0828434337148969 no 268 0.0742905722027691 127 1529343 SGTC_3301 9125354 19.7965 µM 1.44010931403144 0.0835159580265541 no 269 0.0749182371922837 94 41905162 SGTC_3184 9108758 49.47 µM 1.43915073148912 0.0836612977833065 no 270 0.0750539105047167 105 902885 SGTC_1757 st041620 31.8375 µM 1.43887289075553 0.0837034593427417 no 271 0.0750932697942959 81 5289815 SGTC_2969 9091408 28.7 µM 1.43697315245734 0.083992167144525 no 272 0.0753628111244363 104 4286311 SGTC_355 1311-2252 105 µM 1.43521931399209 0.0842593653922096 no 273 0.075612305776671 96 5338538 SGTC_1347 1493-0251 600 nM 1.43396909264446 0.0844502264189062 no 274 0.0757905415359624 98 3986378 SGTC_1779 st039427 55 µM 1.43381936948141 0.0844731051558861 no 275 0.0758119080118005 99 1124498 SGTC_1486 3970-0793 4.53 µM 1.43154293396561 0.0848215333370858 no 276 0.0761373356675442 115 2844330 SGTC_1960 st011366 51.8 µM 1.42845498896872 0.0852958908406703 no 277 0.0765804706684814 122 3972846 SGTC_1937 st074714 47.2 µM 1.42486601290238 0.0858497087159563 no 278 0.0770979678881559 92 17250970 SGTC_2894 9048625 32.47 µM 1.42116281215034 0.086423969352516 no 279 0.0776347164922724 120 4092861 SGTC_729 4092-0585 94.1 µM 1.4179348925337 0.0869268661701639 no 280 0.0781048870711212 103 2169061 SGTC_2757 clomiphene 4.22 µM 1.41398666877652 0.087544951819767 no 281 0.0786829083764258 141 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_678 1218-2179 85.9 µM 1.41274288902015 0.0877403404954679 no 282 0.0788656679977819 103 6820081 YOR116C RPO31 SGTC_543 3844-1095 191 µM 1.410635984782 0.0880720616805496 no 283 0.0791759877053263 122 4230703 SGTC_711 k292-0785 179 µM 1.40708575485162 0.0886331408930021 no 284 0.0797009808256047 114 4146315 SGTC_1063 disulfiram 1.84 µM 1.40692424360847 0.0886587293396508 no 285 0.0797249269069229 105 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2120 5538279 151.968 µM 1.4061253428821 0.0887853811951247 no 286 0.0798434540733082 92 2058197 SGTC_1904 st060225 78 µM 1.40250340244273 0.0893612673465913 no 287 0.0803824875962613 95 66595 SGTC_3156 9099931 49.47 µM 1.40101695742614 0.0895984136580195 no 288 0.0806045011444444 103 18111053 SGTC_664 1222-0054 14.9 µM 1.40100192116323 0.0896008149205256 no 289 0.0806067493054538 123 6813991 SGTC_3332 9141069 11.198 µM 1.39754072948376 0.0901548347973357 no 290 0.0811255138188693 102 17332883 SGTC_2564 betulinic acid 100 µM 1.39654205264808 0.0903151613109334 no 291 0.0812756631621512 106 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_504 lovastatin 124 µM 1.39469151677908 0.0906128039039098 no 292 0.0815544420726491 115 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_317 4495-0002 170 µM 1.39134068519956 0.0911536078346761 no 293 0.0820610709836786 102 15991618 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.38952378344987 0.0914478437411189 no 294 0.082336766950805 122 279621 SGTC_984 1492-0255 2.91 µM 1.38792463807966 0.0917073973206239 no 295 0.0825799972483014 105 1585198 SGTC_2492 derrusnin 100 µM 1.38671272190686 0.0919044638785038 no 296 0.0827646898745101 118 1715307 Part of coumarin class of compounds. SGTC_2087 5276107 200 µM 1.38318211928671 0.0924803535481022 no 297 0.0833045154688789 103 144405 SGTC_71 0417-1750 47.813 µM 1.38077320267302 0.0928748103494897 no 298 0.0836743526828514 101 6811472 SGTC_1512 0259-0544 12.2 µM 1.37780765776212 0.0933621208970731 no 299 0.0841313405436154 127 18476 SGTC_903 1134-0042 114 µM 1.37691668928056 0.0935088968566743 no 300 0.0842690033510254 102 701009 SGTC_2178 5812956 200 µM 1.37654924715878 0.0935694779779092 no 301 0.0843258257418907 104 5403383 SGTC_2165 5727197 32.143 µM 1.37411301361214 0.0939718793350846 no 302 0.0847032999809322 114 1361712 SGTC_978 1416-0512 87.4 µM 1.37133158027865 0.0944328582311761 no 303 0.0851358076944797 115 6814003 SGTC_2007 4011539 71.82 µM 1.37066920854241 0.0945428813550213 no 304 0.0852390488302014 89 45595301 SGTC_2059 5238311 157 µM 1.37044694054093 0.0945798223049195 no 305 0.0852737138331831 119 703021 SGTC_1852 st056254 31.4 µM 1.36657156495081 0.0952256209250871 no 306 0.0858798175305065 102 442583 SGTC_1047 2043-3044 82 µM 1.36543844288611 0.0954150582323355 no 307 0.0860576440861629 132 669592 SGTC_1940 st075990 51.1 µM 1.36411670467753 0.0956363790542124 no 308 0.08626541905026 109 1084979 SGTC_909 3448-9333 149 µM 1.36177827687754 0.0960288662292662 no 309 0.0866339345723439 113 3344074 SGTC_1865 st057639 52.2 µM 1.36047918629812 0.0962474197351032 no 310 0.0868391674984706 125 688818 SGTC_1254 0550-0035 264 µM 1.35590474426561 0.097019914828678 no 311 0.0875647389157325 128 15121435 SGTC_1293 1000-1278 195 µM 1.35472112797989 0.0972205335945493 no 312 0.0877532118888915 127 678847 SGTC_2805 7950783 58.44 µM 1.35305452099398 0.0975035334079455 no 313 0.0880191066342163 118 1178958 YDL195W SEC31 SGTC_1141 3253-0389 52.6 µM 1.35286596811206 0.0975355888177835 no 314 0.0880492266300498 127 5402031 SGTC_224 benfluorex 43.875 µM 1.35219706990407 0.0976493688930695 no 315 0.0881561403999077 98 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1170 0310-0127 64.8 µM 1.35146847924417 0.0977734134031011 no 316 0.0882727052329647 126 774975 SGTC_378 3970-0959 8.33 µM 1.35122111307609 0.0978155544113395 no 317 0.0883123066456147 128 6615653 SGTC_620 0109-0052 432 µM 1.35114059501815 0.0978292742443663 no 318 0.0883251998205722 123 493037 SGTC_805 3852-0218 479 µM 1.35024855819665 0.0979813667889159 no 319 0.0884681335348002 108 6615355 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.34488370777513 0.0988997314431843 no 320 0.0893313961744995 130 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2904 7225135 42.03 µM 1.3436116753091 0.0991184009172044 no 321 0.0895369960360684 145 4446116 SGTC_2680 butyl paraben 22.24 µM 1.3419111701299 0.0994112792738164 no 322 0.0898123997562577 126 7184 An antifungal and steroid mimetic. SGTC_474 dl-dihydrosphingosine 5 µM 1.3401980880953 0.0997069628752664 no 323 0.0900904765165963 121 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1427 4048-4900 550 nM 1.33541749449779 0.100535506601982 no 324 0.0908698710483754 125 24132586 SGTC_2600 tangeritin 87.95 µM 1.3346695998535 0.100665580262255 no 325 0.0909922537418354 137 68077 A bioactive flavone. SGTC_1853 st056710 91.2 µM 1.33008456894861 0.101465691445397 no 326 0.0917452045692504 124 269167 SGTC_2712 st079126 47.7 µM 1.32760482602496 0.101900344386982 no 327 0.0921543447027113 108 3152970 SGTC_2333 9017922 200 µM 1.32741314557623 0.10193399875201 no 328 0.092186026777922 99 3163164 SGTC_2031 5180455 200 µM 1.32275379245177 0.102754556061292 no 329 0.0929586341202362 119 29949 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.3166119005557 0.103843522802554 no 330 0.0939843738560628 120 165521 SGTC_736 0958-0254 92.6 µM 1.31154508399493 0.10474815896293 no 331 0.0948368362575939 137 6812352 SGTC_576 1073-0113 22.7 µM 1.30993096128975 0.10503754173072 no 332 0.0951095959975302 162 5439563 SGTC_2070 5230947 200 µM 1.30476781824041 0.105967084137159 no 333 0.0959859602625601 132 2835538 SGTC_1208 2323-2347 50.3 µM 1.30385029690295 0.106132889506601 no 334 0.0961423148256089 104 5412760 SGTC_526 4469-0568 170 µM 1.30383399902757 0.106135836390415 no 335 0.0961450938336593 120 2901964 SGTC_980 1473-0395 201 µM 1.30341803450748 0.106211068601256 no 336 0.0962160413959172 127 768876 SGTC_1724 st037281 8.293 µM 1.30320153545129 0.10625024031022 no 337 0.0962529830391785 124 574124 YDL195W SEC31 SGTC_1007 4101-0031 70 µM 1.30260139664783 0.106358879456445 no 338 0.0963554403600076 137 1146276 SGTC_830 4076-0286 57.8 µM 1.30194679405663 0.106477469261794 no 339 0.0964672872508527 132 6866659 SGTC_1080 nisoldipine 24.4 µM 1.29273145913045 0.108157088752156 no 340 0.0980519766340333 131 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_990 3985-0011 41.3 µM 1.29243414029361 0.10821159494104 no 341 0.0981034199947166 126 5399565 YGL099W LSG1 SGTC_2005 4024620 188 µM 1.291086117981 0.108458970136359 no 342 0.0983369085928206 130 236743 SGTC_681 1642-0006 26.6 µM 1.29044370516087 0.10857700217556 no 343 0.0984483228798215 135 4446530 SGTC_2601 securinine 100 µM 1.28963688986033 0.108725371128145 no 344 0.0985883805504128 158 442872 A GABA receptor antagonist. SGTC_3171 9103192 49.47 µM 1.28836501227812 0.108959558497571 no 345 0.0988094660017293 113 13018434 SGTC_304 1310-0298 97 µM 1.28779108527545 0.109065352762705 no 346 0.0989093481687222 145 1550234 SGTC_25 0118-0223 35.662 µM 1.28706238548861 0.109199783261871 no 347 0.0990362722996926 117 5333628 SGTC_1313 1220-0047 237 µM 1.28365131883317 0.109830639735996 no 348 0.0996319924365819 137 3528706 SGTC_1316 1272-0050 65.9 µM 1.28306884961702 0.109938624893567 no 349 0.0997339779990966 130 7340392 SGTC_2098 5376439 882.5 nM 1.28195474595721 0.110145383031462 no 350 0.0999292607889602 115 2844116 SGTC_44 0929-0055 61.211 µM 1.28181640230739 0.110171076646821 no 351 0.0999535294769793 135 1379590 SGTC_1929 genistein trimethyl ether 50.5 µM 1.28099029678047 0.110324593036396 no 352 0.100098537161087 128 136420 SGTC_2528 xanthyletin 44.79 µM 1.28004125489423 0.110501144136305 no 353 0.100265313578846 134 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2258 7960471 200 µM 1.27611628971501 0.111233459725853 no 354 0.100957207020669 117 2974708 SGTC_2695 st077686 51.995 µM 1.27548577523143 0.111351423582288 no 355 0.101068677909121 115 2876092 SGTC_2166 5933061 31.504 µM 1.2754348479487 0.111360955547498 no 356 0.101077685437822 122 2877375 SGTC_1236 0330-0013 258 µM 1.27463984591251 0.111509830334589 no 357 0.101218373630354 108 4617066 SGTC_3163 9099914 49.47 µM 1.2744910882429 0.111537703012818 no 358 0.101244714494572 145 16268368 SGTC_617 3770-0098 35 µM 1.27210565037423 0.111985342858854 no 359 0.101667791929955 121 5962639 SGTC_2051 5263410 176 µM 1.27021332378798 0.112341360365338 no 360 0.102004326435698 118 227584 SGTC_1910 st062352 60.4 µM 1.26586918755734 0.113161712643836 no 361 0.102779959733054 116 2245730 SGTC_1509 1326-1131 80 µM 1.2610619415771 0.114074491070802 no 362 0.103643265609724 113 768313 SGTC_3325 9138760 55.175 µM 1.26069975706981 0.114143472900606 no 363 0.103708520760525 112 43844959 SGTC_1152 3909-8331 15.9 µM 1.2579234877231 0.114673229326123 no 364 0.104209714192144 115 16001939 SGTC_819 1013-0258 27.7 µM 1.25449660341687 0.115329543048775 no 365 0.104830779767143 131 5753198 SGTC_1093 fluphenazine 7.97 µM 1.25365486646538 0.115491159364187 no 366 0.104983739708436 143 6602611 An atypical antipsychotic. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.25339929703557 0.115540261383984 no 367 0.105030213591936 140 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2364 9055074 200 µM 1.25089116888445 0.11602292996182 no 368 0.105487093133439 113 6470630 SGTC_2387 9077560 195.08 µM 1.25011310146555 0.116172953100913 no 369 0.105629117247865 121 5303272 SGTC_1934 st074720 32.6 µM 1.24994000207381 0.116206347988356 no 370 0.105660732644136 139 17250992 SGTC_2285 7945142 200 µM 1.24988840948844 0.116216302712366 no 371 0.105670156993271 126 2970608 SGTC_2869 9037858 32.47 µM 1.24202498739627 0.117740621256976 no 372 0.107113671450085 125 27187042 SGTC_3077 9117319 49.47 µM 1.24010336192607 0.118115268669573 no 373 0.10746858282601 146 17154678 SGTC_538 2922-0838 53.3 µM 1.23921929615112 0.118287912365098 no 374 0.107632148215294 151 777039 SGTC_3115 9123671 49.47 µM 1.23600765087085 0.118916595652104 no 375 0.108227859884543 134 3286988 SGTC_3172 9105863 49.47 µM 1.23515429769925 0.11908403660051 no 376 0.108386542298342 128 2348785 SGTC_346 4513-0042 7.16 µM 1.2349996872051 0.119114391347188 no 377 0.108415310276293 145 2827372 SGTC_2558 carylophyllene oxide 100 µM 1.2306034862943 0.119979786128032 no 378 0.109235600350555 132 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2464 5717415 7.67 µM 1.22808668177609 0.120477210779929 no 379 0.109707215014138 132 5285744 SGTC_1443 4112-3303 14 µM 1.22546438588517 0.120997027951535 no 380 0.110200150356258 147 704433 SGTC_2314 7727897 200 µM 1.22302524744351 0.121481952573147 no 381 0.110660080245477 110 900724 SGTC_1440 4100-1550 40 µM 1.21985434932976 0.122114398395409 no 382 0.111260046988702 142 742806 SGTC_1414 3917-0015 5.4 µM 1.2159621706715 0.122893861896979 no 383 0.111999666480142 132 6618702 SGTC_3035 9091303 49.47 µM 1.21564973444357 0.122956582566277 no 384 0.112059189896618 137 25237002 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.21417844645077 0.12325224104665 no 385 0.112339794582734 125 4174840 SGTC_508 roscovitine 141 µM 1.21342134410684 0.123404576369556 no 386 0.112484384969542 152 160355 A CDKinase inhibitor. SGTC_804 1595-0054 20.9 µM 1.21111732949988 0.123868974656474 no 387 0.112925220323988 144 761523 Stimulates phospholipase C. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.21041857011972 0.124010058373909 no 388 0.11305915985148 133 364106 SGTC_1321 1326-2144 215 µM 1.21035194627099 0.124023515998763 no 389 0.113071936355143 141 3513030 SGTC_883 0850-0245 24.6 µM 1.20987819428723 0.124119240578426 no 390 0.113162817829069 154 6823229 YPR165W RHO1 SGTC_2072 5231554 129 µM 1.20593368789246 0.124918260105423 no 391 0.113921530002131 149 789545 SGTC_278 4092-0821 23.9 µM 1.20405726829515 0.125299615968351 no 392 0.114283722289905 132 877900 SGTC_3082 9117008 49.47 µM 1.20156288739508 0.125807821065583 no 393 0.114766463822918 135 41448529 SGTC_1485 3909-9022 254 µM 1.20113975659758 0.125894172149804 no 394 0.11484849671714 141 714516 SGTC_1228 0124-0032 52.5 µM 1.20091154157987 0.125940762643885 no 395 0.114892758358019 119 X1228 SGTC_781 4335-2806 94.4 µM 1.20084166042962 0.125955031406857 no 396 0.114906314030688 155 845254 SGTC_2058 5236698 133 µM 1.19978805308957 0.126170300065748 no 397 0.115110832590122 137 766665 SGTC_1993 st073995 70.8 µM 1.19917646425085 0.126295374918724 no 398 0.115229668407406 149 3098394 SGTC_1513 0337-0559 19 µM 1.19826399444138 0.126482142940125 no 399 0.115407129499822 130 775073 SGTC_2197 6588183 93.1375 µM 1.19716011960794 0.126708345594283 no 400 0.115622075373907 132 884136 SGTC_2146 5545642 200 µM 1.1971548184073 0.126709432579351 no 401 0.115623108306355 140 825326 SGTC_201 4262-0159 12.803 µM 1.19694778652686 0.126751888525022 no 402 0.115663453341822 132 1341029 SGTC_589 1227-0070 34.1 µM 1.19501362637607 0.127149004538129 no 403 0.116040853136701 136 2841384 SGTC_3122 9126309 49.47 µM 1.19228040043578 0.127711657115125 no 404 0.116575658490696 171 17591206 SGTC_1144 3486-0183 12.5 µM 1.1919758377361 0.127774460355829 no 405 0.116635359786088 156 6744069 SGTC_3109 9122853 49.47 µM 1.19134747513084 0.127904101519838 no 406 0.116758601812789 169 1234709 SGTC_510 ag-490 170 µM 1.18471116573794 0.129278858267378 no 407 0.118065833105126 125 5328779 SGTC_1699 st031318 29.054 µM 1.18122262911632 0.13000562483421 no 408 0.118757146977797 155 5340658 SGTC_3294 9122953 26.2835 µM 1.17996008015213 0.130269347205243 no 409 0.11900804622765 138 16459826 SGTC_983 1491-0821 12.2 µM 1.1787842695568 0.130515284232839 no 410 0.119242044839481 132 46495113 SGTC_3097 9117246 49.47 µM 1.17794804624978 0.130690387148824 no 411 0.119408659507327 126 16423892 SGTC_972 1319-0219 195 µM 1.17794105813492 0.130691851125263 no 412 0.11941005255736 160 23903702 SGTC_1716 st033144 30.6155 µM 1.17411704098447 0.131494665345614 no 413 0.120174074337341 152 674617 SGTC_2170 morpholine 200 µM 1.17234437987521 0.131867970284751 no 414 0.120529410228429 129 121171 Reacts with secondary amines. SGTC_1018 4259-0013 28.1 µM 1.17222785650396 0.131892534538963 no 415 0.120552793618869 141 6801262 SGTC_1323 1348-1351 11.2 µM 1.17202515626845 0.131935273230826 no 416 0.120593478209382 142 6989654 SGTC_1873 rapamycin 2 nM 1.17127226316815 0.132094101944631 no 417 0.12074467834773 139 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1857 st056007 79.3 µM 1.17026273547987 0.132307276581803 no 418 0.120947626609594 134 619834 SGTC_2334 9017922 200 µM 1.16859511379873 0.132659935295133 no 419 0.121283398909647 136 3163164 SGTC_70 0141-0289 43.283 µM 1.16853768050832 0.132672092468822 no 420 0.121294974653505 160 352408 SGTC_2842 9000675 19.48 µM 1.16760293966604 0.132870061328195 no 421 0.121483481942066 151 2989072 SGTC_3121 9125696 49.47 µM 1.16286722476941 0.133876163959395 no 422 0.122441688509412 131 1235365 SGTC_2793 7325131 81.82 µM 1.16147034459458 0.134173928562924 no 423 0.122725338183742 148 4176441 SGTC_1758 st042942 75.2445 µM 1.16135032611861 0.134199533390636 no 424 0.122749730548921 158 669317 SGTC_1732 st034308 51.822 µM 1.15636177600217 0.135266763971807 no 425 0.123766604796008 151 830119 SGTC_1409 3909-8004 61.9 µM 1.15565059619109 0.135419383496137 no 426 0.123912051775694 143 2119279 SGTC_1838 st055369 84.5 µM 1.15545875491349 0.135460572928002 no 427 0.123951306684996 136 676036 SGTC_3053 9095903 49.47 µM 1.15469354433371 0.135624953480337 no 428 0.124107972047706 175 17174018 SGTC_2649 anisomycin 9.56 µM 1.15461725201383 0.135641349886936 no 429 0.1241235993448 150 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_106 0092-0003 11.579 µM 1.15314017081586 0.135959065282705 no 430 0.124426427867174 140 1072148 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.15210978233288 0.136180999968557 no 431 0.124637981910761 143 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1588 farnesol 29.9 µM 1.15188822657505 0.136228753083346 no 432 0.124683503417984 154 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1822 st052468 42 µM 1.15183556608218 0.136240104970398 no 433 0.124694324909004 151 2873678 SGTC_2945 9067681 61.76 µM 1.14954896352239 0.136733646350762 no 434 0.125164844496711 182 16456930 SGTC_1419 3993-2473 62.6 µM 1.14907151031628 0.136836854143116 no 435 0.125263247430343 150 704026 SGTC_181 1447-1644 8.07 µM 1.14868514176796 0.136920411758903 no 436 0.125342917379649 171 534600 SGTC_1368 1852-0141 284 µM 1.1462116755082 0.137456159639357 no 437 0.125853789043785 153 2838987 SGTC_1949 st076024 69.1 µM 1.14608484362826 0.137483669696121 no 438 0.125880024085314 174 2921930 SGTC_787 4152-0075 138 µM 1.14492685312557 0.137735013689551 no 439 0.126119729592506 148 9566539 SGTC_1986 st071812 45 µM 1.14403475877411 0.137928858128637 no 440 0.12630461111882 136 11838594 SGTC_661 1304-0007 33.6 µM 1.14288497190192 0.138178971316495 no 441 0.126543176433174 160 3117130 SGTC_1244 0416-0015 52.5 µM 1.14058990699969 0.138679141096431 no 442 0.127020309656 144 96201 SGTC_3169 9102970 49.47 µM 1.14031849981653 0.138738371050173 no 443 0.127076816614326 158 17027839 SGTC_2141 5621638 7.665 µM 1.14019127954851 0.138766140617849 no 444 0.12710330988697 151 2856238 SGTC_2922 7999257 32.47 µM 1.13953435951548 0.138909592989502 no 445 0.127240172848478 151 2988377 SGTC_2786 7743617 45.45 µM 1.13922060944706 0.138978142565006 no 446 0.127305575817183 138 583674 SGTC_303 1348-1668 34.2 µM 1.13758305329337 0.139336297216516 no 447 0.127647313144876 148 5380509 SGTC_222 nsc-310342 10.666 µM 1.13480112582343 0.139946179092237 no 448 0.128229327218762 137 432556 SGTC_566 0958-0068 16.5 µM 1.1331874964954 0.140300765106857 no 449 0.128567761900858 163 6815365 SGTC_1908 st060353 56.5 µM 1.13303546653695 0.140334204262769 no 450 0.128599679841326 171 4227716 SGTC_1692 fluoroquinolonic acid 71 µM 1.13226702196061 0.140503307301632 no 451 0.128761095132841 152 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2047 4141938 200 µM 1.13042292683609 0.140909680902964 no 452 0.12914902895734 165 3807862 SGTC_3052 9092717 49.47 µM 1.12992267639877 0.141020055819285 no 453 0.129254403917327 148 25237534 SGTC_3268 9137683 49.47 µM 1.12935457433047 0.141145472561789 no 454 0.129374143693813 185 1953228 SGTC_1102 cgs 12066b 26.1 µM 1.12791364194856 0.141463918321747 no 455 0.129678195981607 135 6438352 A 5-HT1B full agonist. SGTC_2726 cimetidine 79.27 µM 1.12773247041102 0.141503991623229 no 456 0.129716460128594 166 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2989 9073649 71.4286 µM 1.12655197919224 0.141765292615421 no 457 0.129965976019202 173 21367202 SGTC_325 2810-4341 181 µM 1.12164976764002 0.14285388889619 no 458 0.131005691172336 144 774970 SGTC_2655 perillic acid 100 µM 1.12003494878745 0.143213713094262 no 459 0.131349434680146 152 5702197 An apoptosis inducer. SGTC_1362 1611-0397 101 µM 1.11971392182228 0.143285319245551 no 460 0.131417845241311 157 27816 SGTC_2388 9080168 200 µM 1.11662819521167 0.143974834124463 no 461 0.132076665498755 165 15943073 SGTC_3243 9134147 49.47 µM 1.11608674467704 0.144096053283186 no 462 0.132192502748086 155 24282180 SGTC_2683 piperine 63.03 µM 1.11428533295514 0.144499845976244 no 463 0.132578398583107 177 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_447 ml7 120 µM 1.11307815078384 0.144770866303245 no 464 0.132837433303687 138 4216 Selective myosin light chain kinase inhibitor. SGTC_1209 2323-2347 50.3 µM 1.11290712063172 0.144809291363408 no 465 0.13287416077575 154 5412760 SGTC_2521 angolensin 13.4 µM 1.11094368986208 0.145250904065227 no 466 0.133296294044159 126 821428 A flavenoid. SGTC_753 1322-0200 289 µM 1.11031205952884 0.145393162107651 no 467 0.133432289114816 140 5403907 SGTC_2062 5245942 200 µM 1.11025441714785 0.145406149195885 no 468 0.13344470473175 150 1376160 SGTC_2256 7954252 200 µM 1.10687959045776 0.146167873190905 no 469 0.134172995536401 154 2972920 SGTC_1802 st050112 57.9 µM 1.10632477274313 0.146293355824787 no 470 0.134292986554788 144 4662563 SGTC_1715 st032160 10.2275 µM 1.10528121760558 0.146529571707248 no 471 0.134518876950975 146 5289825 SGTC_693 4161-2696 114 µM 1.10042889716769 0.147631289132989 no 472 0.135572646805058 177 805759 SGTC_424 splitomicin 100 mM 1.10033736952517 0.147652123623391 no 473 0.135592577898116 166 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_98 0074-0023 107.663 µM 1.09870041234373 0.148025077708137 no 474 0.135949381328393 136 3563821 SGTC_1881 5652484 16 µM 1.09312414155625 0.14930026910983 no 475 0.137169648835918 150 2255129 SGTC_1175 0741-0056 27.6 µM 1.0916298709297 0.149643223930472 no 476 0.137497910555067 164 765927 SGTC_1978 st071761 42 µM 1.08794055878275 0.15049221914788 no 477 0.138310674710354 166 5147680 SGTC_2214 7179297 48.276 µM 1.08228866114978 0.151799061751082 no 478 0.139562141378035 151 769744 SGTC_170 4197-0004 226 µM 1.080758980145 0.152154050288664 no 479 0.139902169761556 182 218692 SGTC_2339 9000433 200 µM 1.07997653745446 0.152335842370498 no 480 0.14007631417281 152 2988954 SGTC_1276 0871-0068 94.2 µM 1.07955208920263 0.152434518617645 no 481 0.1401708431171 175 3414906 SGTC_1636 st007707 68.9 µM 1.0785576969308 0.152665862215999 no 482 0.140392474044876 179 403051 SGTC_2028 5153890 36.43 µM 1.07776638618856 0.152850125587706 no 483 0.140569011932671 170 2830968 YPR165W RHO1 SGTC_2036 5160441 105 µM 1.07646002416752 0.15315464556975 no 484 0.140860785054309 193 134534 YIL048W NEO1 SGTC_2560 caryophyllene 100 µM 1.07607980147989 0.153243353006196 no 485 0.140945784106546 178 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2293 7624732 200 µM 1.07587349211959 0.153291500030371 no 486 0.140991919268255 155 894453 SGTC_186 3455-3465 67.277 µM 1.07517000247833 0.153455750832973 no 487 0.141149311519874 170 755278 SGTC_838 0109-0203 71.4 µM 1.07457181036226 0.153595508433904 no 488 0.141283239166431 159 759422 SGTC_3006 9075424 71.4286 µM 1.07411287066593 0.153702789150794 no 489 0.141386048336981 180 7465181 SGTC_1129 3453-1384 223 µM 1.07387020269209 0.153759534718764 no 490 0.141440429982749 172 1084452 SGTC_2951 9072950 58.06 µM 1.0718269970241 0.154237868580704 no 491 0.141898872399502 187 16488155 SGTC_2227 7312221 64.1025 µM 1.0712384803977 0.154375828276833 no 492 0.142031106711827 190 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3274 9138298 49.47 µM 1.06914611947144 0.154866978704186 no 493 0.142501916446043 184 17015756 SGTC_2929 9013348 24.6 µM 1.06779228784597 0.155185319817787 no 494 0.142807108831684 148 2995952 SGTC_948 3448-0295 75.3 µM 1.06758903830324 0.155233149355092 no 495 0.142852965209449 166 678569 SGTC_2872 9044037 25.97 µM 1.06517657670723 0.155801603087182 no 496 0.143398015609923 155 6465195 SGTC_1045 1348-1485 165 µM 1.06039828782907 0.156931568522673 no 497 0.144481720402167 170 6810614 SGTC_2824 7998404 51.95 µM 1.05902363785961 0.157257640675146 no 498 0.144794507332232 161 837851 SGTC_2181 6316240 54.2555 µM 1.05837170872038 0.157412436333352 no 499 0.144943006144658 153 12779990 SGTC_2234 tolnaftate 200 µM 1.05746832341077 0.157627103852103 no 500 0.145148951991024 160 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_690 glyoxal 20.3 µM 1.05700219740959 0.157737942532938 no 501 0.145255292283273 181 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_835 0312-0010 67.2 µM 1.05670168056239 0.157809428653827 no 502 0.145323878889629 182 1626196 SGTC_3276 9139060 49.47 µM 1.0533199500001 0.158615332105989 no 503 0.146097189249596 199 4870619 SGTC_2875 9039966 71.43 µM 1.0520759588368 0.158912466607052 no 504 0.146382350597185 155 6463691 SGTC_1864 st057645 30.4 µM 1.05180665580345 0.158976839199126 no 505 0.14644413237562 190 688666 SGTC_2830 7992007 71.43 µM 1.05168478522534 0.159005976030873 no 506 0.146472096896157 175 1952075 SGTC_1157 4092-0394 27.6 µM 1.05081802926734 0.159213301073622 no 507 0.146671086815717 150 3659885 SGTC_647 0140-0236 81 µM 1.04897657404464 0.159654358220865 no 508 0.147094450138359 174 990837 SGTC_129 0088-0017 176.636 µM 1.04115647171026 0.161536293060771 no 509 0.148901466965423 155 182446 SGTC_1092 toremifene 6.32 µM 1.03595388893124 0.162796291795415 no 510 0.1501118275448 177 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2727 riluzole 51.77 µM 1.0357627007203 0.162842716558554 no 511 0.150156431324582 193 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1330 1469-0054 61.8 µM 1.03491076421508 0.163049690389927 no 512 0.15035529357853 170 7102664 SGTC_3320 9137005 35.139 µM 1.03380358258681 0.163318930185596 no 513 0.150613998233063 187 4908713 SGTC_3037 9091026 49.47 µM 1.02991873014242 0.16426591566218 no 514 0.15152407874088 180 25236398 YIL048W NEO1 SGTC_1472 k841-0093 193 µM 1.02910312313324 0.164465182269164 no 515 0.151715609367695 179 X1472 SGTC_705 1124-0212 310 µM 1.02780613323316 0.164782381416554 no 516 0.152020515329426 213 9554485 SGTC_1111 tnp00062 510.699 nM 1.02751323807118 0.164854068320427 no 517 0.152089427581642 170 676306 SGTC_3193 9111931 49.47 µM 1.02725856450025 0.164916416798447 no 518 0.152149363932671 186 17087244 SGTC_2319 6033012 152.6 µM 1.02410711403766 0.165689209601448 no 519 0.152892342304534 183 847246 SGTC_453 enantio-paf c16 10 µM 1.0216913749224 0.166283175420131 no 520 0.153463497299165 206 13871343 A lipid and platelet activating factor SGTC_1274 0865-0114 173 µM 1.01962416552196 0.166792537556122 no 521 0.153953369818814 174 870624 SGTC_3329 9141233 27.5565 µM 1.01899990892287 0.166946552592666 no 522 0.154101504882956 176 4909101 YNL103W MET4 SGTC_457 grayanotoxin iii 135 µM 1.01864477997707 0.16703421004322 no 523 0.15418581846211 195 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_149 3970-0822 46.1 µM 1.01603185575831 0.167680077623496 no 524 0.154807108556586 183 3114250 YBL034C STU1 SGTC_2434 5670830 169.91 µM 1.01597800338071 0.167693405850077 no 525 0.15481993071773 185 1549830 SGTC_2943 9068529 45.32 µM 1.01586517658511 0.167721332197739 no 526 0.154846796863941 219 3270634 SGTC_969 1313-0238 134 µM 1.01573098429306 0.16775455072966 no 527 0.154878754539332 208 5212874 SGTC_629 3448-6466 76.7 µM 1.01533972685901 0.167851428443828 no 528 0.154971956725692 191 573744 SGTC_509 pifithrin 175 µM 1.009987130552 0.16918037943038 no 529 0.156250727931685 201 4817 A p53 inhibitor. SGTC_1663 st014140 55.4 µM 1.0092568556536 0.169362215549313 no 530 0.156425732874671 174 4207120 SGTC_109 0132-0036 33.701 µM 1.00835289404417 0.169587472774985 no 531 0.156642539259985 161 67274 A color developer. SGTC_823 0417-1665 178 µM 1.00748415401329 0.169804134204417 no 532 0.1568510843993 183 3429856 SGTC_81 0411-0046 9.971 µM 1.00623233009365 0.170116647746822 no 533 0.157151911778859 197 12925265 SGTC_2162 5663267 200 µM 1.00547785550641 0.170305177642278 no 534 0.157333403643405 182 6456493 SGTC_3316 9136639 10.545 µM 1.00321527380384 0.17087135910635 no 535 0.157878502542397 188 4903665 SGTC_2950 9072895 21.46 µM 1.00129402592023 0.171353070698219 no 536 0.158342340132297 178 17332245 SGTC_698 k064-0052 127 µM 1.00040469770806 0.171576344255905 no 537 0.158557348748836 197 5088751 SGTC_2091 4-phenylthiadiazole 200 µM 0.999256980065837 0.171864763334502 no 538 0.158835109796685 171 270010 SGTC_1766 st045414 44.774 µM 0.998764164058195 0.171988701936883 no 539 0.158954474829427 182 253960 SGTC_2517 totarol 10 µM 0.998167472351938 0.172138840650223 no 540 0.159099078261844 173 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_929 2805-0021 398 µM 0.99721438557505 0.172378828434765 no 541 0.159330229874669 204 3098024 SGTC_2981 9013952 38.96 µM 0.997206979904139 0.172380694022096 no 542 0.159332026828545 182 2996344 SGTC_2113 5491891 107.031 µM 0.996039931219129 0.172674850093696 no 543 0.159615371948511 185 789979 SGTC_641 4092-0595 30 µM 0.994329388707895 0.173106572338416 no 544 0.160031266218435 183 786260 SGTC_1999 st074831 12.5 µM 0.993894052091303 0.173216556205129 no 545 0.160137225191589 186 17112523 SGTC_37 0566-0070 1.56 µM 0.993865649824011 0.173223733327587 no 546 0.160144139769087 180 1626686 SGTC_854 0422-0053 192 µM 0.993782523325093 0.173244740100134 no 547 0.160164378170104 209 3596728 SGTC_193 1273-0060 1.558 µM 0.991306547725065 0.173871183807271 no 548 0.160767958364967 185 2847393 YHR072W ERG7 SGTC_2596 sinensetin 100 µM 0.990749806334907 0.174012242432003 no 549 0.160903882090166 188 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1151 3909-8316 15.3 µM 0.988221960143503 0.174653624251176 no 550 0.161521977738389 196 800431 SGTC_3290 9121031 71.43 µM 0.987389663014021 0.17486512821772 no 551 0.161725824961968 176 17014854 SGTC_1945 st075991 56.6 µM 0.987072098918385 0.17494587066808 no 552 0.161803647317377 169 1084980 SGTC_2540 epiandrosterone 100 µM 0.986902212033 0.1749890750721 no 553 0.161845289867321 211 441302 A steroid. SGTC_1633 st005664 67.9 µM 0.985896920936228 0.175244871971654 no 554 0.162091848996667 175 2063822 SGTC_3280 9140961 49.47 µM 0.985448160200033 0.175359135913312 no 555 0.162201991625552 200 4901226 SGTC_153 4077-0274 519.67 µM 0.984698293194371 0.175550173239799 no 556 0.16238614568744 201 3121976 SGTC_2110 5483698 200 µM 0.98453163953746 0.17559264810121 no 557 0.1624270913506 177 2848765 YHR062C RPP1 SGTC_77 0828-0286 12.516 µM 0.983166102549969 0.175940926503092 no 558 0.162762847513705 160 745345 SGTC_2271 7849410 118.62 µM 0.981866563751313 0.176272778099879 no 559 0.163082795040039 202 972430 SGTC_524 r073-0010 27.8 µM 0.978536614498845 0.177124923853509 no 560 0.163904495738026 196 2772106 SGTC_841 0251-0215 91.2 µM 0.974788139021432 0.178087279758378 no 561 0.164832680897005 190 3888614 SGTC_1168 k815-0004 80.5 µM 0.974064717705108 0.178273384371449 no 562 0.165012203266174 204 642433 SGTC_3167 9103034 49.47 µM 0.97328641578271 0.178473744167181 no 563 0.16520548597599 178 5127859 SGTC_1336 1486-0901 104 µM 0.971842936279011 0.178845717266696 no 564 0.165564345939118 182 5006114 SGTC_1182 1222-0449 220 µM 0.970210604207329 0.179266943618751 no 565 0.165970763032681 188 658318 SGTC_94 0334-0113 514.748 µM 0.969307862666777 0.179500165477942 no 566 0.166195803731326 203 6795178 SGTC_1429 4049-0205 9.46 µM 0.968762213881058 0.179641225419866 no 567 0.166331921782493 187 22774478 SGTC_1951 sophoraflavanone G 9.2 µM 0.968753915252622 0.179643371300932 no 568 0.166333992521653 181 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2893 9048488 25.97 µM 0.968046097567704 0.179826459926473 no 569 0.166510674031551 190 6467338 SGTC_2728 chlorpromazine 9.18 µM 0.967102030419612 0.180070840693725 no 570 0.166746515297034 227 2726 A thorazine and dopamine antagonist. SGTC_2111 5486399 200 µM 0.965655812758834 0.180445612042956 no 571 0.167108218599206 192 689674 SGTC_828 2074-0507 139 µM 0.964586347907502 0.180723066532557 no 572 0.167376020030286 188 X828 SGTC_3135 9127742 49.47 µM 0.963197388954537 0.181083807371076 no 573 0.167724237600053 197 3643468 SGTC_2133 5320837 200 µM 0.96182067283934 0.18144181333729 no 574 0.168069845867749 156 2841355 SGTC_1262 0737-0114 49.6 µM 0.959675433562071 0.182000551138463 no 575 0.168609295498491 204 765919 SGTC_1464 k208-0027 110 µM 0.9584552287759 0.182318838777367 no 576 0.168916628633092 203 X1464 SGTC_1078 idebenone 36.1 µM 0.952191193699348 0.183958268573291 no 577 0.170500013162762 219 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1207 2099-0101 141 µM 0.952113392466698 0.183978688338246 no 578 0.170519738850788 198 5837381 SGTC_2332 7982454 138.89 µM 0.951160806480013 0.184228819128941 no 579 0.170761375526103 211 2981748 SGTC_215 1287-0124 461.5 µM 0.949450109534312 0.184678546306769 no 580 0.171195867451239 192 5560863 SGTC_1050 3232-1156 69.3 µM 0.948736502370568 0.184866348934098 no 581 0.171377321969296 206 700529 SGTC_3003 9075612 71.4286 µM 0.948289551681139 0.184984035022881 no 582 0.171491034233416 218 6501993 SGTC_850 0388-0143 75.9 µM 0.947981578341946 0.185065154222556 no 583 0.171569416221704 188 67273 SGTC_3099 9120367 49.47 µM 0.947788411743236 0.18511604496671 no 584 0.171618590540279 220 24824940 SGTC_1790 st045711 43.5 µM 0.947058869976501 0.185308324936045 no 585 0.171804390815405 157 585119 SGTC_677 0929-0063 136 µM 0.944841315176406 0.185893550556212 no 586 0.172369947813495 212 1539583 SGTC_726 3448-4391 34.2 µM 0.944310119289801 0.186033906216251 no 587 0.172505598171364 205 1356692 SGTC_752 1896-0090 130 µM 0.943447155436559 0.186262063550474 no 588 0.172726116502884 207 772567 SGTC_1097 itavastatin 7.23 µM 0.94306023130514 0.186364417943482 no 589 0.172825047868396 207 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2568 diosmetin 100 µM 0.941910715880276 0.186668708756082 no 590 0.173119176675134 225 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_155 k072-0202 43.6 µM 0.940631787201007 0.187007618100881 no 591 0.173446793173386 207 5857737 SGTC_3189 9110682 49.47 µM 0.939240104681982 0.187376838799635 no 592 0.173803741277871 183 17122418 SGTC_1489 4065-0444 182 µM 0.938913827955517 0.187463466897678 no 593 0.173887494493657 197 2877968 SGTC_486 niguldipine 82 µM 0.937207491890497 0.187916910735945 no 594 0.174325918393443 206 1236 A calcium channel blocker. SGTC_126 0417-1624 672.48 µM 0.936891822012816 0.18800087140691 no 595 0.174407103142751 243 41912 YDL195W SEC31 SGTC_1981 st071826 47 µM 0.936567877073158 0.188087057119998 no 596 0.174490441059009 197 11838600 SGTC_1640 st009078 66.4 µM 0.935495033694938 0.18837266171403 no 597 0.174766620770897 216 690618 SGTC_2713 st079149 53.4 µM 0.93423879860932 0.188707427330266 no 598 0.175090363088281 200 3103253 SGTC_701 4424-0219 185 µM 0.933810006678628 0.188821777095353 no 599 0.175200953397446 201 2911779 SGTC_604 1000-0114 314 µM 0.933445132591191 0.188919114939084 no 600 0.175295093448174 211 1572745 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.933048419807045 0.189024981497587 no 601 0.17539748449204 204 97141 SGTC_3074 9116018 49.47 µM 0.932762370785659 0.189101339053712 no 602 0.175471336886198 226 17027303 SGTC_2913 7966556 36.57 µM 0.932434954195617 0.18918876252739 no 603 0.17555589378525 200 2976516 SGTC_1477 0139-0234 16 µM 0.930713054496468 0.18964893628072 no 604 0.176001007516009 199 620880 SGTC_1109 tnp00067 928.257 nM 0.929974204651124 0.189846603136398 no 605 0.176192220239379 189 676295 SGTC_2163 5671233 125 µM 0.928215649088702 0.190317584439725 no 606 0.17664785922853 197 701023 SGTC_2721 ifenprodil 61.44 µM 0.927708619502017 0.190453511715266 no 607 0.176779368053872 200 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2818 7996756 12.99 µM 0.927502195495749 0.19050886806772 no 608 0.176832926199978 235 2241621 SGTC_2511 berberine 10.47 µM 0.924107357264583 0.191420672343339 no 609 0.177715211564229 219 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2450 5739737 12.93 µM 0.92383515013462 0.191493898853294 no 610 0.177786075618372 205 2262825 SGTC_2822 7994718 71.43 µM 0.922441551694825 0.191869059911727 no 611 0.178149152183019 228 1018011 SGTC_2416 tofa 880 nM 0.922045221321051 0.191975835408755 no 612 0.178252494110496 174 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_608 k048-0125 159 µM 0.921489708203537 0.192125557578046 no 613 0.178397406023023 204 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1498 4478-3555 97.6 µM 0.921358969980981 0.192160804590946 no 614 0.178431521361204 186 3437919 SGTC_1957 st077035 62.4 µM 0.920950691812936 0.192270901812618 no 615 0.178538085503722 207 705593 SGTC_2507 purpurin 79.67 µM 0.920537578885777 0.192382342047489 no 616 0.178645952351041 221 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2152 5568786 200 µM 0.919310744206433 0.192713522422062 no 617 0.178966529808989 216 5399883 SGTC_3250 9135583 49.47 µM 0.9173777461505 0.193236035836898 no 618 0.179472364966006 186 7699353 SGTC_1839 st053978 48 µM 0.915073258476047 0.193860096205152 no 619 0.180076586258663 194 3788398 SGTC_289 k017-0060 526 µM 0.914161958909341 0.194107216699806 no 620 0.18031587488194 209 5512909 SGTC_2513 baicalein 25.65 µM 0.913137538462925 0.194385241596473 no 621 0.180585104830409 206 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_521 r062-0005 13.8 µM 0.908961405184545 0.195521139173085 no 622 0.181685249334581 189 2832033 SGTC_1352 1496-0991 99 µM 0.908380647179438 0.195679422510702 no 623 0.181838573453204 218 3000039 SGTC_121 0557-0495 61.343 µM 0.907725652905158 0.195858031963289 no 624 0.182011593539938 233 3104427 SGTC_950 1165-0508 94.1 µM 0.906935708089388 0.196073572441275 no 625 0.182220398387051 205 6148369 SGTC_2677 mitomycin C 100 µM 0.906909845289598 0.19608063166972 no 626 0.18222723718953 222 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2826 7992541 19.48 µM 0.906265253983733 0.196256622094267 no 627 0.182397735852143 251 2985066 SGTC_2210 7115885 190.385 µM 0.902803113085278 0.197203515372884 no 628 0.18331519932256 207 2927039 SGTC_777 1315-0167 517 µM 0.902492161892104 0.19728869538349 no 629 0.183397741636001 216 4221767 SGTC_1100 amiodarone 5.07 µM 0.898812013654657 0.198298501500884 no 630 0.1843763999643 194 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_994 3910-0338 138 µM 0.898789405260799 0.198304714706132 no 631 0.184382422216784 224 3479481 SGTC_147 4466-0538 29.23 µM 0.896262672812288 0.198999847691513 no 632 0.185056245000627 226 6742687 YHR072W ERG7 SGTC_277 nystatin 15.5 µM 0.896164184038984 0.199026972778181 no 633 0.185082540683519 215 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1059 3448-6867 171 µM 0.894585465161949 0.199462076454622 no 634 0.185504362237918 226 3934407 SGTC_331 k048-0133 24.5 µM 0.894138557171883 0.199585350685905 no 635 0.1856238808963 209 6813582 SGTC_1990 st072050 59.8 µM 0.893993153846974 0.199625468339736 no 636 0.185662777075386 217 17233948 SGTC_750 4073-0104 132 µM 0.892421644392213 0.20005936682614 no 637 0.186083487003638 186 22330957 SGTC_2720 fluspirilene 36.88 µM 0.890589650458767 0.200565900927963 no 638 0.186574676755034 208 3396 An atypical antipsychotic. SGTC_1348 1493-0373 93.8 µM 0.889429378237413 0.200887106408121 no 639 0.186886180984996 240 3010129 SGTC_3026 9090633 49.47 µM 0.889304459307014 0.200921706899216 no 640 0.186919737790137 214 25236842 SGTC_3113 9123498 49.47 µM 0.889149008947757 0.200964769087428 no 641 0.18696150141833 252 8897275 SGTC_3248 9135562 49.47 µM 0.888920451666829 0.201028093094075 no 642 0.187022916593168 214 17650701 SGTC_706 4262-0057 46.9 µM 0.888760529312759 0.201072408246448 no 643 0.187065896433153 211 883298 SGTC_2100 5377183 190 µM 0.88830742113456 0.201197998230137 no 644 0.187187704435444 208 2844202 SGTC_2897 9048598 12.99 µM 0.887867142282038 0.201320077299421 no 645 0.187306110534927 199 6467404 SGTC_1457 k015-0032 57.3 µM 0.886963422451575 0.201570796824984 no 646 0.187549296857278 210 4302660 SGTC_1578 josamycin 24.2 µM 0.886895307748693 0.201589701505255 no 647 0.187567634074244 217 5282165 A P450 substrate. SGTC_105 0111-0055 734.78 µM 0.886888134080481 0.201591692560184 no 648 0.18756956536803 183 5179370 SGTC_1963 st076565 50.3 µM 0.886786850787107 0.201619805042458 no 649 0.187596834151167 232 4914280 SGTC_1743 st037606 46.3785 µM 0.88527591499038 0.20203946350323 no 650 0.188003918378747 173 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_31 0508-1974 57.237 µM 0.88523156168087 0.202051790411655 no 651 0.188015876512608 189 6810525 SGTC_569 4130-2812 160 µM 0.884978555695469 0.20212211579131 no 652 0.188084098651539 201 743552 SGTC_880 0833-0487 87.2 µM 0.880558288915295 0.203353131983753 no 653 0.189278471572319 228 76075 SGTC_843 0310-0051 143 µM 0.879242678463803 0.203720383245587 no 654 0.189634854245598 220 2065037 SGTC_2355 9061122 103.12 µM 0.878474449748955 0.203935016221152 no 655 0.189843148708992 228 5302957 SGTC_1921 5740136 50 µM 0.877542913141007 0.204195455951577 no 656 0.190095910453934 183 1774243 SGTC_2714 st079313 56.9 µM 0.876423847683154 0.204508586907971 no 657 0.190399829306471 191 2939799 SGTC_1625 st003711 30.1 µM 0.875441926988116 0.204783577982152 no 658 0.190666747652727 209 24207034 YER133W GLC7 SGTC_2496 diffractaic acid 79.83 µM 0.87363056315635 0.205291434789174 no 659 0.191159738176058 209 94870 An apoptosis inducer which activates caspases. SGTC_2213 7173844 200 µM 0.871306225154899 0.205944210349452 no 660 0.191793486183332 220 892728 SGTC_1860 st056228 74.6 µM 0.870763604850768 0.20609677888982 no 661 0.191941620642891 232 688679 SGTC_1034 k072-0165 12.7 µM 0.870539515745911 0.206159805567736 no 662 0.192002817030322 227 5835461 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.869972437358131 0.206319351495548 no 663 0.192157733532386 252 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1706 st031321 9.9705 µM 0.868066981306793 0.206855982024874 no 664 0.192678832748745 209 6103185 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.866134311603351 0.207401119748164 no 665 0.193208255494874 230 4620898 SGTC_2877 9040724 71.43 µM 0.864295614613764 0.207920538607794 no 666 0.193712759312592 199 6463895 SGTC_1387 3342-1166 1.8 µM 0.862675495263878 0.208378846758604 no 667 0.194157954533868 191 3418228 SGTC_1681 tripelennamine 100 µM 0.862601146207388 0.208399893312963 no 668 0.1941783999767 192 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2154 5570129 200 µM 0.859883144633409 0.209170159095222 no 669 0.194926730341454 242 673366 SGTC_2159 5658611 73.75 µM 0.859732755156651 0.209212827475492 no 670 0.194968187271243 201 793844 SGTC_460 trequinsin 123 µM 0.859036619915546 0.209410401142365 no 671 0.195160156366011 234 5537 A vasodilator. SGTC_1958 st076513 41.9 µM 0.858555263957769 0.209547081394257 no 672 0.195292964204849 224 732122 YGL099W LSG1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.857905152872131 0.209731762665757 no 673 0.195472419327952 228 688751 SGTC_2931 9014674 55.67 µM 0.856519952848632 0.21012558446688 no 674 0.195855120553461 218 2996810 SGTC_2529 gangaleoidin 93.61 µM 0.855810194264585 0.210327541867927 no 675 0.196051387760961 225 4565183 SGTC_2251 lansoprazole 556 µM 0.85234953277857 0.211313882928667 no 676 0.197010060875343 203 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_954 1189-0853 2.85 µM 0.852153242178995 0.211369909814595 no 677 0.197064522235633 225 2828194 SGTC_2653 dihydrofissinolide 100 µM 0.85206400587749 0.211395383254168 no 678 0.197089284102351 227 6857746 SGTC_2622 2-methoxyxanthone 59.94 µM 0.85148751271376 0.211559992606404 no 679 0.197249298528139 210 71034 A hepatoprotective. SGTC_1647 st011722 22.4 µM 0.849529418949796 0.212119658208194 no 680 0.197793383703492 216 2854783 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.849329977210987 0.21217671151185 no 681 0.197848852365789 231 1377 SGTC_3317 9138495 8.753 µM 0.846720326325856 0.212924067605958 no 682 0.198575513162359 234 17020139 SGTC_922 1866-0035 480 µM 0.846694331364534 0.212931519804707 no 683 0.198582759582262 237 3156169 SGTC_1870 st057514 26.5 µM 0.846193646681726 0.213075085077587 no 684 0.198722362805319 228 5393161 SGTC_2283 7944793 200 µM 0.845295848238196 0.21333265927633 no 685 0.198972839269565 228 2970533 SGTC_2835 9006588 71.43 µM 0.844768283474895 0.213484099792449 no 686 0.199120113078373 200 2345538 SGTC_924 2046-0044 21.3 µM 0.842660573803403 0.214089754883454 no 687 0.199709151591068 215 3623589 SGTC_3298 9116858 71.43 µM 0.840517974638355 0.21470645925399 no 688 0.20030901386888 242 2506942 SGTC_2367 9070478 135.38 µM 0.839826542244616 0.214905694364552 no 689 0.200502824611187 218 572802 SGTC_48 0382-0018 55 µM 0.839597100158129 0.214971831447302 no 690 0.200567162849852 204 762596 SGTC_2401 5128683 200 µM 0.83831161484091 0.215342593403736 no 691 0.200927857171147 229 708373 SGTC_836 0330-0104 1.35 µM 0.837683437198007 0.215523908386763 no 692 0.20110425900375 217 46494820 SGTC_931 2812-0076 566 µM 0.837508172483555 0.215574511970433 no 693 0.201153492567714 228 3450959 SGTC_253 dyclonine 31.25 µM 0.836324865087006 0.215916344532016 no 694 0.201486084228872 207 3180 An oral anasthetic. SGTC_514 4466-0038 2.65 nM 0.836016166484669 0.216005572678477 no 695 0.20157290416757 229 5722064 SGTC_1130 3454-2858 15.9 µM 0.834520225263238 0.216438271214371 no 696 0.201993947529721 247 715628 YIL048W NEO1 SGTC_3273 9137859 49.47 µM 0.834003853176379 0.216587747367712 no 697 0.202139406272636 249 2377234 SGTC_2635 hydroquinidine 100 µM 0.833687834598264 0.21667925589389 no 698 0.202228457609596 209 442912 An experimental heart treatment. SGTC_1029 k015-0030 64.7 µM 0.833050147398977 0.216863977083262 no 699 0.202408223861043 231 2208316 SGTC_295 k015-0027 31 µM 0.832726117012481 0.216957875026255 no 700 0.202499605762298 210 3887424 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.832169703245771 0.217119168132798 no 701 0.202656581130642 222 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2224 6650123 117.647 µM 0.831183639588461 0.217405178172674 no 702 0.202934947835057 227 2908370 SGTC_2470 5664817 21.68 µM 0.830158641562697 0.217702711667032 no 703 0.203224547686292 228 2859561 SGTC_709 3807-1509 243 µM 0.829603216488699 0.217864036963138 no 704 0.203381578806612 256 1886677 YPL242C IQG1 SGTC_2414 st077232 92.9 µM 0.827404021144537 0.218503478050786 no 705 0.20400405108846 204 729801 SGTC_2304 7443016 91.4 µM 0.826835085586763 0.218669078328403 no 706 0.204165270341269 223 939854 SGTC_2352 9027995 87.8 µM 0.825303677226398 0.219115184670254 no 707 0.204599602338514 212 2997347 SGTC_3288 9119690 36.221 µM 0.822925498987908 0.219808995254087 no 708 0.205275180589029 239 17595618 YKL019W RAM2 SGTC_2376 9072922 81.32 µM 0.822475441566792 0.219940436929867 no 709 0.205403179097243 214 17087968 SGTC_2259 7964009 200 µM 0.821962584219269 0.220090274627453 no 710 0.205549095976899 211 313134 SGTC_107 0358-0022 2.6945 µM 0.819615313761222 0.22077680592322 no 711 0.206217720443667 225 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2243 6634756 200 µM 0.819364644128787 0.220850194357067 no 712 0.206289200281378 193 885676 SGTC_2095 5432005 200 µM 0.816452290449297 0.221703866034891 no 713 0.207120749988731 246 783734 SGTC_3059 1327-0034 3 µM 0.816017207148367 0.221831559706891 no 714 0.207245147153741 228 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2465 5809242 33.21 µM 0.814167670801157 0.222374853319973 no 715 0.207774451632478 256 2731748 SGTC_343 4130-2827 29.8 µM 0.813562350507566 0.222552828355947 no 716 0.20794785683427 221 1118244 SGTC_131 0141-0277 33.849 µM 0.812541401479304 0.222853189632642 no 717 0.208240520095531 237 1547771 SGTC_2784 7567673 72.73 µM 0.810850371402696 0.223351195218311 no 718 0.208725801750921 226 3471247 SGTC_101 0490-5701 117.494 µM 0.81023410676758 0.223532841470198 no 719 0.208902819246796 212 4661669 SGTC_2202 7226349 200 µM 0.809321449221011 0.223802004917218 no 720 0.209165135842369 205 844334 SGTC_2563 tomatine 8.54 µM 0.807885765271461 0.224225793351237 no 721 0.209578173254356 228 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2947 9072639 7.68 µM 0.806370032036937 0.224673704982568 no 722 0.210014760528073 248 16488146 SGTC_2636 apigenin dimethyl ether 100 µM 0.805624488545875 0.224894205277486 no 723 0.210229700574948 241 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2939 9044578 71.43 µM 0.805535544270148 0.224920519427994 no 724 0.210255351815716 240 2653634 SGTC_1708 st033234 31.827 µM 0.80369871029296 0.225464336519263 no 725 0.210785499575883 221 674664 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.803287155553233 0.225586284302607 no 726 0.210904390093997 214 5379071 SGTC_2440 5628896 157.78 µM 0.802400553438457 0.225849120148385 no 727 0.211160646527214 253 5522048 SGTC_1710 st031758 61.5 µM 0.801522632224678 0.226109553079051 no 728 0.211414573600569 244 5394341 SGTC_2912 7964298 10.93 µM 0.800984461041161 0.226269283964842 no 729 0.211570320855708 243 2975850 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.800125385092623 0.226524392433504 no 730 0.211819077403001 250 2346 DNA damaging agent; causes G2/M arrest. SGTC_796 1234-0020 70.7 µM 0.799963904214432 0.226572363406912 no 731 0.211865855378542 237 46495034 SGTC_403 arphamenine a 50 µM 0.799062048754428 0.226840382189868 no 732 0.212127217064532 244 5487158 An arginine aminopeptidase inhibitor. SGTC_2865 9030313 51.95 µM 0.798619213031747 0.22697205219534 no 733 0.212255621785619 230 42562754 SGTC_338 4055-0136 114 µM 0.797888348041932 0.227189457261822 no 734 0.212467642856331 230 2900563 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.797402337321156 0.227334092270239 no 735 0.212608701130889 223 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3267 9137951 49.47 µM 0.797370407198917 0.227343596373362 no 736 0.212617970346763 256 16643986 SGTC_914 3820-6779 408 µM 0.797083521465332 0.227428998871491 no 737 0.212701262974681 228 2893481 SGTC_2105 5350118 200 µM 0.796765041342597 0.227523827809248 no 738 0.212793750832972 229 2133313 SGTC_1459 k035-0031 35.7 µM 0.796298251825493 0.227662856786252 no 739 0.212929350724382 224 3877128 YMR208W ERG12 SGTC_707 0865-0008 204 µM 0.796271428251759 0.227670847394538 no 740 0.212937144362784 264 723043 SGTC_362 0310-0100 9.03 µM 0.795254729780104 0.227973833157674 no 741 0.213232670675048 221 790235 SGTC_3331 9141060 1.957 µM 0.794834678226548 0.228099078677183 no 742 0.213354837908698 226 4906567 YPR165W RHO1 SGTC_2145 5634607 200 µM 0.794169038262257 0.228297629779546 no 743 0.213548515289424 232 308662 SGTC_236 1509-0011 5.31 µM 0.793696203880031 0.228438728660522 no 744 0.213686155366904 277 3107280 SGTC_1227 3909-8010 46.6 µM 0.792537148162784 0.22878481057067 no 745 0.214023770075833 213 15982272 SGTC_755 1995-0008 37.3 µM 0.790726716092107 0.229325975106955 no 746 0.214551741238832 214 689533 SGTC_104 0074-0074 590.992 µM 0.78924682379709 0.229768869009235 no 747 0.21498387988399 215 3943124 SGTC_2265 7929201 200 µM 0.788727455340597 0.22992441617123 no 748 0.215135658756587 263 1265108 SGTC_3050 9093513 49.47 µM 0.788019984253245 0.230136393532128 no 749 0.215342508294838 254 25236664 SGTC_636 0kpi-0074 126 µM 0.785076378252055 0.23101954986904 no 750 0.216204394240401 248 616434 SGTC_2873 9040596 71.43 µM 0.784587198912755 0.231166499154934 no 751 0.216347818941154 261 6463863 SGTC_1702 st027038 51 µM 0.783373819484742 0.231531222905768 no 752 0.216703812766125 235 5521182 SGTC_2321 7390090 138.78 µM 0.782752156803548 0.231718209638675 no 753 0.216886333772771 227 649046 SGTC_1072 oxiconazole 14.9 nM 0.780860998058384 0.232287558599068 no 754 0.217442126626431 233 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2371 9071574 200 µM 0.780563929670136 0.232377064172289 no 755 0.217529506752431 243 45596039 SGTC_3098 9119039 49.47 µM 0.779708949086986 0.232634773593791 no 756 0.217781105055883 245 17161528 SGTC_849 0386-0493 241 µM 0.779308792319772 0.232755443954182 no 757 0.217898918314026 251 726119 SGTC_1441 4106-0040 13 µM 0.774761928151055 0.234129026324181 no 758 0.219240174935349 233 2904180 SGTC_1879 gemcitabine 100 µM 0.774447193237187 0.234224271813148 no 759 0.219333192290817 253 60750 A nucleoside analog which inhibits DNA replication. SGTC_2878 9043973 25.97 µM 0.774382328445551 0.234243903946361 no 760 0.219352365373093 241 6465167 SGTC_1378 2093-0007 380 nM 0.774015317288745 0.234355001578757 no 761 0.21946086663501 269 3618014 SGTC_3272 9137413 49.47 µM 0.771209230078643 0.235205392932841 no 762 0.220291462050673 258 17614870 SGTC_659 k018-0002 107 µM 0.770977942412288 0.235275561136974 no 763 0.220360002978351 246 6797879 YHR007C ERG11 SGTC_275 trichlorophene 5.69 µM 0.769619376445971 0.235687957004425 no 764 0.220762853834339 238 62616 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.768695028029287 0.235968772860627 no 765 0.221037188598124 281 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2652 actinonin 100 µM 0.768284877597494 0.236093435068337 no 766 0.221158978453104 252 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_544 k015-0020 52.4 µM 0.767726547306903 0.236263193752636 no 767 0.221324830445767 252 3008304 SGTC_997 3996-0078 137 µM 0.767352727047205 0.236376890261327 no 768 0.221435913483569 239 735687 SGTC_888 0916-0002 6.97 µM 0.76453282197472 0.237235527294095 no 769 0.222274892473253 231 2802138 YIL048W NEO1 SGTC_54 0159-0055 9 µM 0.763457811600079 0.23756330926274 no 770 0.22259520674596 257 3319099 SGTC_2444 5485484 36.41 µM 0.76164276279077 0.238117300376304 no 771 0.223136622555306 265 6790631 SGTC_2136 5328288 199.296 µM 0.760903920519582 0.238343013178976 no 772 0.223357228348945 244 262395 SGTC_963 1269-2853 151 µM 0.759242885390078 0.238850879083824 no 773 0.223853638195127 227 3668223 SGTC_1670 st016595 4.04 µM 0.758809005834018 0.23898363634039 no 774 0.223983408791117 277 597879 SGTC_1628 st004252 77.7 µM 0.758344697709589 0.239125748721239 no 775 0.224122327708682 249 692968 SGTC_2276 7947513 42.08 µM 0.757807421625849 0.239290252284661 no 776 0.224283139372513 258 2105100 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.757719097443427 0.23931730135993 no 777 0.224309581879399 236 521171 SGTC_1829 berberine 14.4 µM 0.755876656398873 0.239881925286846 no 778 0.22486157551645 256 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2561 acetosyringone 100 µM 0.755109327323946 0.2401172907049 no 779 0.225091693552356 278 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1394 3474-0001 65.7 µM 0.755073037669985 0.240128425068718 no 780 0.225102579936046 221 5017666 YIL048W NEO1 SGTC_1174 0739-0097 51.1 µM 0.752557246366368 0.240901003858247 no 781 0.225858008623041 255 728447 SGTC_3110 9122132 49.47 µM 0.75191895027973 0.241097234157415 no 782 0.22604990060936 231 918317 SGTC_2571 chrysanthemic acid 100 µM 0.75097922691093 0.241386289825945 no 783 0.226332578803612 277 2743 An insecticide. SGTC_1446 4239-0190 62 µM 0.750242087368679 0.241613163107158 no 784 0.226554457426824 241 1340085 SGTC_3307 9126885 69.2785 µM 0.74949258209573 0.241843960903669 no 785 0.226780183974246 234 24824909 SGTC_1684 st024538 14.6195 µM 0.748749715505792 0.242072832416273 no 786 0.227004036323986 247 6732859 SGTC_1786 berberine 21.6 µM 0.748625220807486 0.242111199768097 no 787 0.227041563228713 261 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_146 3448-8650 53.125 µM 0.748514318285079 0.242145380996984 no 788 0.227074995938498 276 2891488 YIL048W NEO1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.747711976800416 0.24239274830948 no 789 0.227316952720349 241 688664 SGTC_1481 3346-2004 36 µM 0.747698497364812 0.242396905279831 no 790 0.227321018864395 284 2770522 SGTC_308 4092-1169 104 µM 0.746887877866267 0.242646966057079 no 791 0.227565621908629 265 2268590 YDL196W YDL196W SGTC_29 0299-0004 12.984 µM 0.744677073272105 0.243329666778568 no 792 0.228233481142766 242 16871 A napthoquinone isolated from Swertia calycina. SGTC_2026 5148700 152 µM 0.743586141841701 0.243666930624133 no 793 0.228563444844483 256 79838 SGTC_2675 theaflavin digallate 100 µM 0.742493917104758 0.244004846987322 no 794 0.228894067972295 256 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2180 6301957 200 µM 0.742105714213549 0.244125011438879 no 795 0.229011643988902 247 845462 SGTC_1696 st025591 34.7925 µM 0.741609835499825 0.244278552305981 no 796 0.229161881335043 247 2787147 SGTC_209 4077-0173 175.592 µM 0.741349561418673 0.244359162815268 no 797 0.229240759198818 238 15993494 SGTC_90 0870-0863 4.608 µM 0.74108326501975 0.244441653355482 no 798 0.229321477921346 267 1738164 SGTC_1683 st010134 710 nM 0.739379366279476 0.244969824422966 no 799 0.22983833401797 256 3818134 SGTC_1067 clotrimazole 1.36 µM 0.737997300167204 0.245398685064873 no 800 0.230258044877753 247 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1610 st001799 48.1 µM 0.737810101966784 0.245456804425889 no 801 0.230314926851265 252 621897 SGTC_2092 5303694 80.6725 µM 0.737662502218828 0.245502634883268 no 802 0.230359781993913 249 1963699 SGTC_499 genistein 192 µM 0.737503309822822 0.245552070068413 no 803 0.230408165583745 277 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_456 gingerol 170 µM 0.735390680402821 0.246208626480911 no 804 0.231050798015276 287 442793 A herb. SGTC_1439 4092-1168 46 µM 0.734503463565402 0.246484633384458 no 805 0.231320975006264 272 2886240 SGTC_2216 7189485 200 µM 0.73426248218325 0.246559629614015 no 806 0.231394389543301 245 731273 SGTC_834 0312-0008 75.7 µM 0.73409863925212 0.24661062643388 no 807 0.231444311411654 255 6385573 YIL048W NEO1 SGTC_1571 st070080 73.4 µM 0.73409356786438 0.246612205015354 no 808 0.231445856726105 261 4315245 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.733303806112807 0.246858101844959 no 809 0.231686577077682 257 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2486 5283202 22.39 µM 0.733269718529362 0.24686871816234 no 810 0.231696970154823 254 1377751 SGTC_1218 1348-1416 30.7 µM 0.73296143649701 0.246964741343407 no 811 0.231790975091 256 6787668 SGTC_2471 5466956 24.79 µM 0.732961051508943 0.246964861271351 no 812 0.231791092499313 257 724419 SGTC_3286 9117135 37.221 µM 0.732463814795559 0.247119781892057 no 813 0.23194276049672 253 3438150 SGTC_3038 9091290 49.47 µM 0.731700097734984 0.247357829155594 no 814 0.232175818378224 250 25236843 SGTC_1015 4130-4525 82 µM 0.730095142337968 0.247858485911236 no 815 0.232666015204374 264 1363237 SGTC_1126 isoteolin 1.0172 µM 0.729308708769754 0.248104006731318 no 816 0.232906423151134 247 133323 SGTC_2832 7992762 51.95 µM 0.728907823295787 0.248229211173036 no 817 0.23302902447446 258 2985177 SGTC_788 1182-0090 188 µM 0.728877306481868 0.248238743555851 no 818 0.233038358786608 251 5715185 SGTC_2755 lomerizine 42.69 µM 0.728649922490239 0.248309776488515 no 819 0.233107916265439 253 3949 A calcium channel blocker. SGTC_2460 5552655 174.22 µM 0.727860761189295 0.248556388183748 no 820 0.233349412593991 259 5401989 SGTC_2553 4-methylesculetin 85.09 µM 0.727038394617715 0.248813515248228 no 821 0.233601217915639 252 5319502 SGTC_2101 5377231 179.231 µM 0.726888357189717 0.24886044230311 no 822 0.233647175016636 268 2844213 SGTC_2895 9054447 58.44 µM 0.723913949343255 0.249791716528085 no 823 0.23455928276709 274 2697450 SGTC_1014 4130-3005 69.3 µM 0.72325053977579 0.249999679274407 no 824 0.234762986851475 264 743608 SGTC_810 3825-7150 143 µM 0.722553548567826 0.250218267974192 no 825 0.234977107700557 231 22330411 YGL099W LSG1 SGTC_79 0052-0007 94.094 µM 0.720281927068127 0.250931391316879 no 826 0.235675714985326 254 2801472 SGTC_812 4251-0442 148 µM 0.720225952945665 0.250948976674564 no 827 0.235692943538621 274 5723007 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.719976814301811 0.251027256329555 no 828 0.235769635585241 280 688801 SGTC_1211 1056-0033 32.3 µM 0.719724368992698 0.25110658811896 no 829 0.235847359551513 251 6741922 SGTC_1792 st045773 43.6 µM 0.719245684560948 0.251257052724569 no 830 0.235994777786683 214 2919270 SGTC_2552 juarezic acid 87.02 µM 0.719176874124223 0.251278685788469 no 831 0.236015973192778 255 1549512 SGTC_2817 7995342 71.43 µM 0.716966683754191 0.251974063040731 no 832 0.236697327032363 270 18879975 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.716646872959426 0.252074766983316 no 833 0.236796007303623 280 7104 SGTC_190 3970-0790 3.722 µM 0.716637691233453 0.252077658493812 no 834 0.236798840735312 256 2832352 SGTC_3031 9088762 49.47 µM 0.71577537369497 0.25234929763184 no 835 0.237065030413371 266 205253 SGTC_966 1300-0360 30.2 µM 0.715088160135348 0.252565887601799 no 836 0.237277284749176 269 70588 SGTC_1342 1486-1464 234 µM 0.714942284554558 0.252611875991457 no 837 0.237322353636753 274 3253938 SGTC_2112 5488546 200 µM 0.713739446476868 0.252991247945377 no 838 0.237694154764821 277 600757 SGTC_2001 4023502 57.655 µM 0.713475739636712 0.253074460436083 no 839 0.237775710087768 256 108941 YCR052W RSC6 SGTC_2240 6690706 185.951 µM 0.713276866371677 0.253137224264366 no 840 0.237837224799039 253 805876 SGTC_2173 5763948 167 µM 0.712804248588795 0.253286413913425 no 841 0.237983448118104 266 2867177 SGTC_710 3448-4187 58 µM 0.712460347598615 0.253395001020123 no 842 0.23808987868994 248 3946412 SGTC_400 oxethazaine 37.5 µM 0.712349470968285 0.253430015650385 no 843 0.238124198379664 262 4621 A local anesthetic. SGTC_2734 clemastine 41.6 µM 0.712173332835928 0.253485644967406 no 844 0.23817872406297 295 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1085 doxorubicin 7.67 µM 0.711476618073801 0.253705749719936 no 845 0.238394467551618 272 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_860 0443-0016 25.1 µM 0.71095933053189 0.253869235076316 no 846 0.238554719114995 279 5337942 SGTC_2892 9047358 58.44 µM 0.710668187054205 0.253961273388205 no 847 0.238644938973291 256 6466771 SGTC_643 k048-0106 28.4 µM 0.709844195627214 0.254221854192958 no 848 0.238900379510078 271 6763920 SGTC_3175 9106517 49.47 µM 0.707267625683421 0.2550375778907 no 849 0.239700090103518 272 41468073 SGTC_2377 9073351 62.6 µM 0.707257568874593 0.25504076448531 no 850 0.239703214375144 273 7337946 YHR072W ERG7 SGTC_1121 fusaric acid 630.51 nM 0.707101917157776 0.255090086853755 no 851 0.239751572333085 242 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_806 3966-4455 5.86 µM 0.706216489206107 0.255370753033928 no 852 0.240026758798806 262 714982 SGTC_429 1112-0049 25.5 µM 0.705812224427199 0.2554989520035 no 853 0.240152459461044 261 2836170 SGTC_2132 5317594 122.667 µM 0.705035852632159 0.25574524644819 no 854 0.240393962351039 284 794577 SGTC_1452 4194-0072 190 µM 0.704693071783663 0.255854028906752 no 855 0.240500631910488 269 1343545 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.70298733893742 0.256395706858671 no 856 0.241031819910461 259 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2654 protoveratrine a 100 µM 0.702664862423065 0.256498180655776 no 857 0.241132315064777 291 5702278 A heart drug and vasodilator. SGTC_197 4544-0043 41.561 µM 0.702054272383817 0.256692267105819 no 858 0.241322659023592 272 896523 SGTC_2323 6148992 148.28 µM 0.701143263479742 0.256981988901122 no 859 0.241606806590449 277 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.701043625578129 0.257013686363795 no 860 0.241637895093937 261 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2405 ticlatone 3.52 µM 0.700906948678864 0.257057170223384 no 861 0.241680543846732 252 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.700871331936597 0.257068502345524 no 862 0.241691658390377 287 91467 include heat shock SGTC_1548 st061468 90.8 µM 0.700747400151096 0.257107935549119 no 863 0.241730334646698 267 390799 SGTC_2883 9059145 45.46 µM 0.700408704932366 0.257215719244413 no 864 0.24183605075775 290 16476510 SGTC_480 am 92016 50 µM 0.699413381107409 0.257532599142598 no 865 0.242146863882988 313 2129 K+ channel blocker. SGTC_1237 0330-0133 46.1 µM 0.699380567263133 0.257543049493269 no 866 0.242157114459109 285 X1237 YHR072W ERG7 SGTC_1193 1488-0126 41.5 µM 0.69848406782272 0.257828646290074 no 867 0.242437259066906 260 1384710 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.697787652243375 0.258050615974804 no 868 0.242655001136612 280 6708784 An antioxidant flavonoid SGTC_1721 st082152 9.2685 µM 0.697343305583718 0.258192295091294 no 869 0.242793986369138 282 5296051 SGTC_1381 2324-0066 62.1 µM 0.696389878010909 0.258496429757081 no 870 0.243092350121248 274 10885928 SGTC_3275 9138069 49.47 µM 0.696239855390321 0.258544302489699 no 871 0.243139315953133 272 17617007 SGTC_1484 3473-2379 286 µM 0.695659204682058 0.258729633388041 no 872 0.243321139732146 269 671917 SGTC_2801 7907800 81.82 µM 0.695284658255944 0.258849216818551 no 873 0.243438463413643 283 6620925 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.6946881986391 0.259039710671051 no 874 0.243625362706392 252 6312947 SGTC_2804 7954240 19.48 µM 0.693863379279301 0.259303256142067 no 875 0.243883945627654 269 828705 SGTC_2806 7952793 58.44 µM 0.69254223747567 0.259725674581117 no 876 0.244298435278589 273 2972490 SGTC_1344 1488-0097 29.1 µM 0.691885270126076 0.259935863745582 no 877 0.2445046908088 294 747966 SGTC_3019 9081971 49.47 µM 0.691727132523081 0.259986471154693 no 878 0.244554352265603 275 16451803 SGTC_3212 9128307 49.47 µM 0.690407809976766 0.260408880477796 no 879 0.244968883350443 260 27243542 SGTC_130 0136-0219 337.655 µM 0.690219482480264 0.260469206370851 no 880 0.245028086660349 307 234244 SGTC_772 k072-0172 35.3 µM 0.689473235541602 0.260708318214928 no 881 0.245262755192629 252 5861980 SGTC_255 tunicamycin 200.472 nM 0.687804221638782 0.261243510853328 no 882 0.245788038636595 266 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2426 5582046 32.21 µM 0.687651917611602 0.261292377360206 no 883 0.245836002851948 260 2251934 SGTC_2189 6047310 154.431 µM 0.687257846855993 0.261418836130253 no 884 0.245960128560629 272 711535 SGTC_2236 dapsone 200 µM 0.687097844092711 0.261470190581554 no 885 0.246010536357159 263 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_768 0384-0033 77.3 µM 0.684815631730452 0.262203252406094 no 886 0.246730134998897 272 3965305 YMR134W ERG29 SGTC_1749 st037932 54.2 µM 0.682373528181497 0.262988836927475 no 887 0.247501395057174 291 594497 SGTC_1377 2944-0135 198 µM 0.680824222318091 0.263487846129094 no 888 0.247991360654657 263 1894137 SGTC_2134 5324836 1.464 µM 0.680607189969301 0.263557787707108 no 889 0.248060038107268 292 699272 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.680139493170996 0.263708541456376 no 890 0.248208069999563 277 688803 SGTC_1720 st037298 9.481 µM 0.679903429697702 0.263784649019593 no 891 0.248282804930194 294 597396 SGTC_2735 sertaconazole 140 nM 0.679619602769306 0.263876170489592 no 892 0.248372677093318 299 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_878 0828-0289 13.7 µM 0.6785241417887 0.264229559333616 no 893 0.248719711065087 279 745350 YLR208W SEC13 SGTC_187 1488-2104 32.728 µM 0.675413739790623 0.265234267524356 no 894 0.249706469272057 273 2852859 SGTC_220 paclitaxel 373.376 µM 0.67517363999982 0.265311904055514 no 895 0.249782725974584 266 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2964 9083345 53.42 µM 0.67473505242445 0.265453751605344 no 896 0.249922055147695 277 17741579 SGTC_1184 1269-1718 139 µM 0.674611711004875 0.265493649493709 no 897 0.249961245306304 272 5403821 SGTC_809 3998-0021 90 µM 0.674288902127683 0.265598084553359 no 898 0.250063829133744 283 715485 SGTC_1798 st045719 60.953 µM 0.674094780643866 0.265660896725073 no 899 0.250125528787229 269 3980186 SGTC_3123 9126162 49.47 µM 0.673468459769663 0.265863607628847 no 900 0.250324653921072 264 25239884 SGTC_2303 7774051 200 µM 0.673380707245754 0.265892015294168 no 901 0.250352559643038 302 2953184 SGTC_989 1501-0895 10.3 µM 0.672803622366649 0.266078870270973 no 902 0.250536116467179 281 2830112 SGTC_2267 7931562 200 µM 0.672583088434274 0.266150294765343 no 903 0.250606281835592 264 934880 SGTC_3159 9100096 49.47 µM 0.671463257752912 0.266513124927139 no 904 0.250962729220505 268 25236875 SGTC_3085 9117376 49.47 µM 0.671271061980576 0.266575422362708 no 905 0.251023933005529 278 16480349 SGTC_1966 st070145 16.1 µM 0.671021886450503 0.266656199910042 no 906 0.251103293465472 288 3748532 SGTC_1564 D-Arginine 115 µM 0.670895812294805 0.266697075254775 no 907 0.251143452155209 296 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3066 9117245 49.47 µM 0.670398343062203 0.266858393979495 no 908 0.251301945312447 272 17176980 SGTC_2937 9044753 11.33 µM 0.669759967756029 0.267065477756416 no 909 0.251505408437495 273 6465530 YGL099W LSG1 SGTC_2403 6032726 181.2 µM 0.668879116509915 0.26735135192663 no 910 0.251786296402632 275 2881040 SGTC_3130 9127414 49.47 µM 0.666296643534324 0.268190364449026 no 911 0.252610755276348 284 1494646 SGTC_1299 1079-1439 3.74 µM 0.665849986662494 0.268335611849431 no 912 0.252753495349628 290 323161 SGTC_2856 9022925 19.48 µM 0.66361489490833 0.269063030455961 no 913 0.253468410811976 268 4944862 SGTC_2534 helenine 20.12 µM 0.663406365969998 0.269130947382798 no 914 0.253535164938236 271 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_46 0329-0187a 2.197 µM 0.662726592010731 0.269352406377836 no 915 0.25375283777969 285 46494817 SGTC_2342 7990637 118.86 µM 0.661829653454458 0.269644753723361 no 916 0.254040199753145 300 2033102 YER133W GLC7 SGTC_1526 st051518 75 µM 0.661770364952437 0.269664083763771 no 917 0.254059200669985 283 673993 SGTC_401 neomycin 50 µM 0.661502480700484 0.26975143166858 no 918 0.254145062130976 264 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2308 7584454 197.62 µM 0.6610030906926 0.269914303511827 no 919 0.254305165747204 284 893577 SGTC_1818 st052136 56.3 µM 0.658793388027112 0.270635569672928 no 920 0.255014226884933 277 674169 SGTC_1269 0831-0796 3.05 µM 0.657351952049094 0.27110658511066 no 921 0.255477319330606 281 927758 SGTC_2658 polymyxin b sulfate 77.05 µM 0.656898434965115 0.271254864572939 no 922 0.255623112306513 281 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1467 k284-1082 293 µM 0.65659264106171 0.271354868086866 no 923 0.255721440959568 297 3334705 SGTC_2691 st077356 60.2 µM 0.654878103894371 0.271915911741942 no 924 0.256273119436651 309 2839272 SGTC_970 1315-0089 19.5 µM 0.653991584504452 0.272206231383917 no 925 0.256558613707878 272 6811083 YLR033W RSC58 SGTC_515 4092-1064 102 µM 0.653545106174087 0.272352503560104 no 926 0.256702460070573 321 717353 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.653258455858613 0.272446434552885 no 927 0.256794835181585 289 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_826 1683-5028 118 µM 0.653249303892966 0.272449433779253 no 928 0.256797784752868 289 722377 SGTC_1370 2001-0092 44.6 µM 0.652449297014573 0.272711670499401 no 929 0.257055685722491 290 790957 SGTC_1349 flufenamic acid 69 µM 0.651862004751285 0.272904260529461 no 930 0.257245098861697 286 3371 A non-steroidal anti-inflammatory. SGTC_837 0091-0265 12.5 µM 0.651546060329423 0.273007895690732 no 931 0.25734702706837 294 759367 SGTC_904 1141-0088 396 µM 0.649602834188387 0.273645735731789 no 932 0.257974400940684 297 1378119 SGTC_1527 coumarin 137 µM 0.648814983777396 0.273904547821511 no 933 0.258228985639691 324 323 A hepatotoxic, DNA x-linker. SGTC_2357 9067248 200 µM 0.647452823375073 0.274352308383404 no 934 0.258669458967153 301 9150235 SGTC_463 ikarugamyin 104 µM 0.646131752856337 0.274786907023403 no 935 0.25909701655104 311 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2044 5102272 200 µM 0.645892166797377 0.274865761092018 no 936 0.259174596454622 285 592666 SGTC_314 1671-0008 2.74 µM 0.644021884702986 0.275481703147647 no 937 0.259780621400616 298 3913060 SGTC_1046 2001-0062 216 µM 0.64385217215845 0.275537628347955 no 938 0.259835649288499 298 739778 SGTC_3007 9078383 71.4286 µM 0.64281888625859 0.275878246428159 no 939 0.26017081341327 280 6496995 SGTC_2905 7799065 20.05 µM 0.642400340918265 0.276016276872298 no 940 0.260306639206012 284 1296806 SGTC_2526 patulin 37.61 µM 0.641692120750912 0.276249915268824 no 941 0.260536553082659 288 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1411 3909-8223 150 µM 0.638308559039852 0.27736747332597 no 942 0.261636420764108 296 X1411 SGTC_1794 st048918 76.9 µM 0.638245288687159 0.277388391954241 no 943 0.261657010230575 271 672303 SGTC_2490 carminic acid 95.39 µM 0.638100905225413 0.277436131323141 no 944 0.261703998674827 268 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1847 st056231 15 µM 0.637514551232801 0.277630046382114 no 945 0.261894867382891 284 5393180 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.637383761107028 0.277673309445441 no 946 0.261937451642752 276 6857784 SGTC_1900 st060200 72.8 µM 0.636793224403096 0.277868689547375 no 947 0.262129770051137 286 688945 SGTC_1778 st046819 58.9 µM 0.636033019589603 0.278120303400842 no 948 0.262377450278893 299 671715 SGTC_2203 7227154 166.4 µM 0.634689234564568 0.278565343264003 no 949 0.262815558122218 283 896304 SGTC_2855 9016525 58.44 µM 0.634418656616109 0.278654996237956 no 950 0.26290381859241 302 43811474 SGTC_1992 st073643 23.3 µM 0.634033680534407 0.278782577962869 no 951 0.263029420978773 296 3161292 SGTC_3072 9116419 49.47 µM 0.633970929303732 0.2788033765214 no 952 0.263049897116514 279 17170162 SGTC_51 1013-0126 23.419 µM 0.632877168808911 0.279166018811872 no 953 0.26340692913196 293 1627850 SGTC_1355 1499-0035 1.68 µM 0.631707048858094 0.279554232190914 no 954 0.263789160584455 300 1548538 SGTC_500 h-89 112 µM 0.631042815720894 0.27977472290362 no 955 0.26400626480153 312 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3028 9087778 49.47 µM 0.630939598282585 0.279808993275303 no 956 0.264040009533978 281 17217395 SGTC_651 3253-0966 34.4 µM 0.629820322684317 0.280180747150115 no 957 0.264406073817428 294 781462 SGTC_2779 methotrexate 400 µM 0.628832232144313 0.280509128245235 no 958 0.264729447961529 297 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2516 gossypol 71.55 µM 0.628128179058116 0.280743226192208 no 959 0.264959987303697 299 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1920 st075728 45.7 µM 0.6263832616226 0.281323818902604 no 960 0.265531792884054 296 3400306 SGTC_2731 amoxapine 43.43 µM 0.623489341116083 0.282287999371768 no 961 0.266481502245227 320 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_95 0471-0001 561.058 µM 0.623150591882304 0.282400965846424 no 962 0.26659278315063 277 4015405 SGTC_1680 diphenhydramine 100 µM 0.622914073923469 0.28247985300998 no 963 0.266670494472733 287 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2593 nobiletin 86.24 µM 0.622153681742196 0.282733542659558 no 964 0.266920409649083 278 72344 An anti-infammatory. SGTC_430 0958-0115 16.4 µM 0.62125592174503 0.283033203179235 no 965 0.267215625204189 305 6833180 SGTC_69 0096-0274 206.684 µM 0.621065074324058 0.283096925189698 no 966 0.267278403885698 313 6741392 SGTC_349 k015-0014 24 µM 0.618439779995984 0.283974182238076 no 967 0.26814274115287 299 2196908 SGTC_1826 st055655 41.6 µM 0.618161513815722 0.284067242656764 no 968 0.268234438344977 298 676168 SGTC_1553 gossypol 38.6 µM 0.61799159129324 0.284124076933494 no 969 0.268290440755603 291 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_74 000s-0487 160.283 µM 0.615667996648278 0.284901798731124 no 970 0.269056831777196 262 677548 SGTC_3070 9117005 49.47 µM 0.614828673632595 0.285182974887623 no 971 0.269333935482859 303 8779016 SGTC_218 alverine citrate 93.75 µM 0.614793864469511 0.285194638934951 no 972 0.269345430868171 304 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1056 3448-1962 115 µM 0.614506744012302 0.285290857519785 no 973 0.269440258970712 303 715507 SGTC_99 0109-0120 622.8 µM 0.613048735302639 0.285779697694342 no 974 0.269922057838876 307 759414 SGTC_3232 9132874 49.47 µM 0.612987645057757 0.28580018868313 no 975 0.269942254514366 286 3784940 SGTC_489 paxilline 115 µM 0.61160037782469 0.286265696094456 no 976 0.27040109403012 299 105008 A toxic potassium channel blocker. SGTC_188 3229-0966 278.469 µM 0.611181460529491 0.286406337520696 no 977 0.270539727778021 303 5722370 SGTC_527 4476-4215 268 µM 0.610109464921107 0.286766383569226 no 978 0.2708946486047 287 4418754 SGTC_3349 9149703 23.001 µM 0.609572499409138 0.286946812229514 no 979 0.271072516713956 294 4910494 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.609349046152779 0.287021911799711 no 980 0.271146552050276 278 6708739 YPR165W RHO1 SGTC_775 4577-0580 57.3 µM 0.607968898840207 0.287485966542791 no 981 0.271604050760316 313 2006902 SGTC_14 0354-0009 295 µM 0.607657148782268 0.287590837130313 no 982 0.271707444549949 314 1713507 SGTC_2231 micatex 6.853 µM 0.605903929844002 0.288180944546817 no 983 0.27228927486192 313 20737 An antifungal of unknown mechanism. SGTC_3293 9120939 62.045 µM 0.605230327881963 0.288407820746373 no 984 0.2725129836285 313 934087 SGTC_1637 st007924 17.4 µM 0.604900614033461 0.288518902509984 no 985 0.272622517573847 290 683336 SGTC_2700 st077718 96.8 µM 0.603378854045698 0.289031849912697 no 986 0.273128343113779 297 904970 SGTC_2022 5136654 200 µM 0.602297329448839 0.289396665502679 no 987 0.273488119087223 314 1713771 SGTC_9 0092-0002 10.449 µM 0.59879511306542 0.290579501269771 no 988 0.274654760786057 318 759368 SGTC_1320 1313-0481 95.3 µM 0.598004925756465 0.290846690935801 no 989 0.2749183231923 293 6813365 YLR208W SEC13 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.596883672803939 0.29122602232761 no 990 0.275292524397418 311 5377381 SGTC_1104 tacrolimus 29.8 µM 0.59546109167368 0.291707628273702 no 991 0.275767649838529 307 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2798 7813637 45.45 µM 0.594861829074307 0.291910615936104 no 992 0.275967917098331 304 956368 SGTC_1621 st003705 32.4 µM 0.594768235564864 0.291942324717016 no 993 0.275999201513097 313 24207032 SGTC_779 1360-0071 233 µM 0.594733781160247 0.291953998015483 no 994 0.276010718625109 292 7566 SGTC_1070 indatraline 8.81 µM 0.59223268828919 0.292801958831044 no 995 0.276847391519365 317 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_92 0063-0024 660.874 µM 0.591372230392619 0.293093949271043 no 996 0.277135521314665 305 3594437 SGTC_1677 st019204 53.9 µM 0.588454788802705 0.294084966722522 no 997 0.278113535920709 291 3945625 SGTC_1519 esterone 74 µM 0.586764486798577 0.294659848292576 no 998 0.278680945462119 317 698 A steroid. SGTC_2719 novobiocin 32.65 µM 0.586204579318922 0.294850390316549 no 999 0.278869022369247 320 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1645 Cervolide 78 µM 0.586202444106507 0.294851117059035 no 1000 0.278869739720491 326 23173 A fragrance. SGTC_1925 st057770 10.1 µM 0.586027694097346 0.294910597901 no 1001 0.278928452209396 291 5989122 SGTC_1950 st077106 7.18 µM 0.582607019637224 0.296076027835801 no 1002 0.280078939405144 292 13831864 SGTC_2725 haloperidol 53.21 µM 0.581750468273237 0.296368186988669 no 1003 0.28036738592257 301 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.581636040115267 0.296407227034053 no 1004 0.280405930874015 325 6710655 SGTC_1122 capsaicin 818.572 nM 0.579993515505159 0.296967875219589 no 1005 0.280959495344282 325 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1783 st039459 87.517 µM 0.579637843974768 0.297089341591196 no 1006 0.281079433469852 356 729761 SGTC_1302 1159-0335 255 µM 0.57930079660024 0.297204468536235 no 1007 0.281193114053145 307 649284 SGTC_3147 9097027 49.47 µM 0.578664705441812 0.297421796889714 no 1008 0.281407717700588 339 25236841 SGTC_586 0957-0265 8.15 µM 0.578096666928138 0.297615935549076 no 1009 0.281599428612637 313 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2472 5377652 49.4 µM 0.57802988802906 0.29763876238827 no 1010 0.281621970382778 331 1610903 SGTC_725 1497-0963 19 µM 0.577288313055967 0.297892306515137 no 1011 0.28187235362171 312 3549977 SGTC_100 0086-0128 49.5915 µM 0.577089820412429 0.297960187757851 no 1012 0.281939390299245 328 93297 SGTC_1901 st060216 58.6 µM 0.576441321648823 0.298182012878723 no 1013 0.282158460513255 310 688792 SGTC_2232 chlorophetanol 41.5365 µM 0.575905503922924 0.298365351116826 no 1014 0.282339527598193 306 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3146 9095609 49.47 µM 0.57534309901962 0.298557841737299 no 1015 0.282529639308573 311 17173999 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.573409608664799 0.299220035229608 no 1016 0.283183692962065 297 6708514 SGTC_1833 st055984 71 µM 0.572004466689882 0.299701694520321 no 1017 0.283659474294212 313 676288 SGTC_1290 0986-0249 10.2 µM 0.571536914229487 0.299862041560859 no 1018 0.283817872500695 323 53329 SGTC_2838 9002687 71.43 µM 0.570352730527729 0.300268330806102 no 1019 0.284219241575169 317 6457060 SGTC_2732 terfenadine 20 µM 0.569117022681931 0.300692562910855 no 1020 0.284638363450014 329 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2733 amorolfine 100 µM 0.568894218383749 0.30076908285413 no 1021 0.284713964605465 348 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_597 k018-0003 82.8 µM 0.568091384426055 0.3010448811129 no 1022 0.284986458805907 332 6786234 SGTC_551 k048-0028 34.9 µM 0.566431305919674 0.301615530574934 no 1023 0.285550309136666 318 6836383 SGTC_1076 itraconazole 331 nM 0.56632107239324 0.301653440402702 no 1024 0.285587769056452 314 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1744 st037937 38.9 µM 0.566173536067178 0.301704182191564 no 1025 0.285637908995909 315 1016152 SGTC_405 ebelactone b 50 µM 0.565061768263103 0.302086672990165 no 1026 0.286015875814882 309 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2295 7971645 200 µM 0.564309489504621 0.30234560919923 no 1027 0.28627176218155 324 2978226 YKL099C UTP11 SGTC_1883 5-benzylidenerhodanine 20 µM 0.56424768580195 0.302366886611575 no 1028 0.286292789439231 299 1273210 SGTC_5 0352-0601 109.883 µM 0.563057084789091 0.302776910690581 no 1029 0.286698006522754 310 762456 SGTC_1328 1441-0025 69.2 µM 0.562199298840421 0.303072472786096 no 1030 0.286990119546798 318 4562601 SGTC_1114 scopoletin 1.73284 µM 0.56126283230698 0.303395292662486 no 1031 0.287309187574245 315 5280460 A coumarin with genotoxic properties. SGTC_2067 5224629 34.075 µM 0.560439009733371 0.30367940874074 no 1032 0.287590014835882 312 2835000 SGTC_548 1436-0017 110 µM 0.559733342340723 0.30392287039811 no 1033 0.287830668110131 321 9677137 SGTC_740 k014-0057 261 µM 0.559204506373464 0.304105380644471 no 1034 0.288011079009413 336 4012779 SGTC_833 3852-0053 558 µM 0.559149671177303 0.304124307993594 no 1035 0.288029788935913 324 3123681 SGTC_1501 4491-0275 38.4 µM 0.558364938419752 0.304395230033112 no 1036 0.288297604837449 333 5104718 SGTC_3016 9080866 49.47 µM 0.556565939664871 0.305016723498658 no 1037 0.288912015206144 320 17066299 SGTC_161 4065-0411 162.148 µM 0.556074875640109 0.305186467434937 no 1038 0.289079834837173 322 1906281 YLR208W SEC13 SGTC_246 cycloheximide 667 µM 0.555791131520032 0.305284567121248 no 1039 0.289176824418005 310 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1817 st052116 64.4 µM 0.553877024643464 0.305946702064232 no 1040 0.289831504926838 310 4361398 SGTC_2142 5622915 118.518 µM 0.55332603159917 0.306137421361034 no 1041 0.290020089452304 313 5322196 SGTC_2056 5235370 200 µM 0.552090552824967 0.306565257752954 no 1042 0.290443157078825 309 5511916 SGTC_639 0833-0042 114 µM 0.551590054831528 0.306738651294617 no 1043 0.290614625855308 334 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_874 0599-0792 117 µM 0.550568776836623 0.307092599073673 no 1044 0.290964658784494 328 765305 SGTC_2106 5357045 167.29 µM 0.550488608823771 0.307120390790074 no 1045 0.290992143914706 320 668842 SGTC_112 phenothiazine 287.218 µM 0.550447231656465 0.307134735379826 no 1046 0.291006330306992 340 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3279 9140807 49.47 µM 0.54931652572537 0.307526841415221 no 1047 0.291394124133654 312 45595718 SGTC_2219 9098279 200 µM 0.547731727749566 0.308076787685258 no 1048 0.291938061580568 300 902349 SGTC_2090 5301565 104.445 µM 0.547439136946832 0.308178367830828 no 1049 0.292038536849469 327 2056344 SGTC_385 1494-0393 12.4 µM 0.546587828582648 0.308474004167516 no 1050 0.292330966459575 320 3090647 SGTC_1295 1013-0063 9.78 µM 0.54631511219061 0.308568737465154 no 1051 0.292424674993113 328 6826038 SGTC_599 1935-0052 86.5 µM 0.545909590297266 0.308709626877561 no 1052 0.292564042861862 306 9557311 SGTC_2703 st077852 53.4 µM 0.544366967189175 0.309245833575839 no 1053 0.293094486170849 329 6281836 SGTC_1707 st032323 6.317 µM 0.543322048182203 0.309609272300106 no 1054 0.293454043152315 302 3132057 YMR211W DML1 SGTC_2816 7982706 58.44 µM 0.543057650149149 0.309701263496872 no 1055 0.293545054984975 317 2981853 SGTC_1406 3909-7906 11.9 µM 0.542908267860107 0.30975324288904 no 1056 0.293596481553572 340 X1406 SGTC_2037 5169046 200 µM 0.54080963118907 0.310483890919444 no 1057 0.294319401856639 303 5718022 SGTC_1682 st012968 530 nM 0.538286064651476 0.311363470806089 no 1058 0.295189785262718 307 24207270 SGTC_1010 4112-3296 15.2 µM 0.53741410866577 0.31166763871449 no 1059 0.295490799942605 316 704384 SGTC_2787 5284540 71.43 µM 0.537214486113966 0.31173729194085 no 1060 0.29555973304343 339 736958 SGTC_682 0kpi-0099 17 µM 0.536616301327616 0.311946053674444 no 1061 0.295766340799956 319 1714895 YML126C ERG13 SGTC_2936 9038235 15.59 µM 0.535617010848802 0.312294932865509 no 1062 0.296111634862314 313 4749415 SGTC_2674 ligustilide 100 µM 0.53459026196106 0.312653573900558 no 1063 0.296466609432687 323 5319022 A signalling regulator. SGTC_1643 st009866 20.2 µM 0.5322700264084 0.313464680106003 no 1064 0.297269494390161 301 3156273 YOR207C RET1 SGTC_1245 0418-0076 17.2 µM 0.531381404181773 0.313775563334004 no 1065 0.297577252572014 353 6790114 SGTC_2043 5101342 149 µM 0.530968318400238 0.313920125858483 no 1066 0.297720366837415 334 678451 SGTC_496 calpeptin 138 µM 0.530794246148991 0.313981052328582 no 1067 0.29778068386518 316 73364 A calpain inhibitor. SGTC_1392 3455-1037 33.9 µM 0.529761746286766 0.314342538493586 no 1068 0.298138565480993 335 981132 SGTC_1856 st057054 55.7 µM 0.529414432716918 0.314464175704766 no 1069 0.298258994162416 350 1266018 SGTC_2799 7812892 81.82 µM 0.528119709081417 0.314917795173321 no 1070 0.298708126081639 331 20205235 SGTC_2889 9059656 51.95 µM 0.527002569692063 0.315309420758761 no 1071 0.299095901995697 330 3949838 SGTC_2079 5212404 121 µM 0.526339005279686 0.315542138927721 no 1072 0.299326343331845 308 758462 SGTC_961 1252-1571 372 µM 0.52582662862318 0.315721884226301 no 1073 0.299504335563251 355 6813498 SGTC_2850 9015429 58.44 µM 0.522798345003294 0.31678511627859 no 1074 0.300557295720174 340 6457570 SGTC_1325 1431-0015 227 µM 0.520768223363912 0.317498742108225 no 1075 0.301264120949617 320 1103340 SGTC_1458 k015-0034 6.33 µM 0.518393708400518 0.318334289903842 no 1076 0.302091801751351 340 3598957 SGTC_2930 9013230 14.89 µM 0.517909982621842 0.31850461759155 no 1077 0.302260538359137 329 2995857 SGTC_2887 9044784 58.44 µM 0.515869933817957 0.319223373582396 no 1078 0.302972627239283 322 6465546 SGTC_245 methotrexate 289.6 µM 0.514868617747358 0.319576409180576 no 1079 0.303322415910368 314 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3009 9080819 71.4286 µM 0.514472622045387 0.319716071167708 no 1080 0.303460798452711 325 17027216 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.512505688903868 0.320410158758231 no 1081 0.304148569924349 330 1241132 A phosphatase inhibitor. SGTC_1292 0kpi-0043 232 µM 0.512421984923107 0.320439710020499 no 1082 0.304177853839981 343 3333905 SGTC_3145 9085516 49.47 µM 0.511017225569526 0.320935822884124 no 1083 0.304669497515528 336 25236195 SGTC_2614 arthonioic acid 13.39 µM 0.510139561067189 0.321245946333096 no 1084 0.304976845529031 317 6710684 SGTC_2458 5808907 16.39 µM 0.508978248949486 0.32165648851881 no 1085 0.305383735198845 365 2731747 SGTC_2135 5326629 150.42 µM 0.508887898673012 0.321688437910399 no 1086 0.305415401374804 327 5020077 SGTC_1815 st051655 58.2 µM 0.508232126422933 0.321920369618345 no 1087 0.305645281587581 329 5984156 SGTC_1697 st025554 27.742 µM 0.507394112893551 0.322216856904396 no 1088 0.305939157792814 326 1269519 SGTC_1775 st081588 35.1725 µM 0.507366539866555 0.322226614102603 no 1089 0.305948829279901 338 1426443 YGL099W LSG1 SGTC_1358 1509-0022 2.48 µM 0.506439552632245 0.322554716013391 no 1090 0.306274057088248 342 3258434 SGTC_626 0214-0009 33 µM 0.506055908734523 0.322690545068711 no 1091 0.306408700898963 341 3437874 SGTC_3333 9141820 12.094 µM 0.504384858761329 0.323282455829517 no 1092 0.306995477984933 353 1939433 SGTC_2975 9084847 53.72 µM 0.504374345111423 0.323286181339231 no 1093 0.30699917134444 310 27211724 SGTC_2307 7538926 6.34 µM 0.504213769687431 0.323343083410162 no 1094 0.307055582615579 333 96582 SGTC_1612 st002233 45.4 µM 0.502788797375918 0.32384822252794 no 1095 0.307556385357261 330 1035021 SGTC_476 mead acid 10 µM 0.501776786098902 0.324207168094268 no 1096 0.307912272058955 355 5312531 An omega 9 fatty acid. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.501239756372964 0.324397711071677 no 1097 0.308101198857979 335 688669 SGTC_3078 9116413 49.47 µM 0.49837990296866 0.325413186299156 no 1098 0.309108149547173 329 17177322 SGTC_719 2810-4230 27.3 µM 0.496813655880938 0.325969878891881 no 1099 0.309660232194925 341 721079 SGTC_3143 9086658 49.47 µM 0.496794182294527 0.325976802851444 no 1100 0.309667099099299 345 25236626 SGTC_2385 9074692 200 µM 0.496440730923211 0.326102485198674 no 1101 0.309791746994752 324 17046906 SGTC_3020 9089140 49.47 µM 0.496419508310314 0.326110032290834 no 1102 0.309799232041731 331 17217859 SGTC_1840 st055363 71 µM 0.494532149844257 0.326781490905685 no 1103 0.310465203423734 337 676033 SGTC_1569 carminic acid 40.6 µM 0.49330662774087 0.327217791177211 no 1104 0.310897973020456 326 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1600 coumarin 106 71.1 µM 0.49260541126385 0.327467538760446 no 1105 0.311145711899352 366 100336 A hepatotoxic, DNA x-linker. SGTC_2760 etidronate 98.04 µM 0.491779512054013 0.327761792809681 no 1106 0.311437610790668 339 3305 A chelator and antioxidant. SGTC_1210 3013-0140 750 nM 0.490877632111798 0.32808323972149 no 1107 0.311756499117115 353 905973 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.490611220026876 0.32817821836069 no 1108 0.311850724605296 345 5106787 A p450 inhibitor. SGTC_2275 7947463 200 µM 0.490449660511705 0.328235821395616 no 1109 0.311907871496939 335 1225414 SGTC_2379 9035213 200 µM 0.489770894044816 0.328477875948636 no 1110 0.312148014487955 347 646551 SGTC_613 3914-0030 117 µM 0.48774746760812 0.329199875922226 no 1111 0.312864362556221 333 1145395 SGTC_210 3551-0445 56.827 µM 0.487575393397529 0.329261304971567 no 1112 0.31292531417844 344 2865180 YOR207C RET1 SGTC_2864 9034755 47.6 µM 0.485914024141084 0.329854636745128 no 1113 0.313514062366609 319 4930451 SGTC_3285 9112818 20.8695 µM 0.485802806113507 0.329894371819933 no 1114 0.313553492280096 341 17017947 YPR165W RHO1 SGTC_2689 tacrolimus 100 µM 0.485521246423305 0.329994973762281 no 1115 0.313653322618669 346 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1479 0549-0158 134 µM 0.483219357886888 0.330817904596203 no 1116 0.314469995946035 309 5440202 SGTC_1656 st012921 11 µM 0.483059257914159 0.330875171211843 no 1117 0.314526830706595 341 6732821 SGTC_2381 9035592 200 µM 0.482811760788401 0.330963706952319 no 1118 0.314614699707613 340 4749657 SGTC_1962 st076595 64.5 µM 0.482734553271523 0.330991327893471 no 1119 0.314642112871373 348 279619 SGTC_2353 9059630 146.67 µM 0.482416486003564 0.33110512596023 no 1120 0.314755056043689 349 4779114 SGTC_2250 alverine citrate 130 µM 0.481881713927706 0.331296491811275 no 1121 0.314944988441915 322 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1172 0370-0043 85 µM 0.481350991157423 0.331486452200738 no 1122 0.315133531064776 334 376585 SGTC_1134 3477-0009 42.5 µM 0.480510927621646 0.331787222836073 no 1123 0.315432067407667 391 3973534 SGTC_1658 st012944 20 µM 0.480207889995795 0.331895746995262 no 1124 0.315539788548495 347 24207260 SGTC_723 4182-0001 115 µM 0.47942006270174 0.332177950535934 no 1125 0.315819911779419 352 744821 YLR208W SEC13 SGTC_1836 st055642 81 µM 0.479020284528879 0.332321189428124 no 1126 0.315962099093232 375 8571 SGTC_2718 lomofungin 53.02 µM 0.478758265113319 0.332415083208251 no 1127 0.316055305140275 344 5351222 A RNA synthesis inhibitor. SGTC_2300 7976697 71.57 µM 0.478518921205069 0.332500860488046 no 1128 0.316140455231446 324 2236109 SGTC_2841 9004761 38.96 µM 0.477679436420477 0.332801788604527 no 1129 0.316439191274319 307 2991039 SGTC_831 k061-1017 217 µM 0.476755680101413 0.333133049845594 no 1130 0.316768054340953 364 1240153 SGTC_2457 5731572 11.68 µM 0.475977626115622 0.333412162935519 no 1131 0.317045158861482 374 2865357 SGTC_573 3702-0553 84.7 µM 0.475042656246161 0.333747688857437 no 1132 0.317378284860891 331 1222756 SGTC_3321 9137793 26.8275 µM 0.474889552668591 0.33380264471727 no 1133 0.317432849156145 349 4904192 SGTC_525 k781-2675 26.7 µM 0.473430828996981 0.334326425861945 no 1134 0.317952919765524 347 3651118 YDL195W SEC31 SGTC_1897 st060201 15 µM 0.47322558587652 0.334400148041487 no 1135 0.318026122801807 334 611878 SGTC_1035 k081-0041 55.2 µM 0.47316550938405 0.334421728389661 no 1136 0.318047551328947 361 731709 SGTC_3134 9127454 49.47 µM 0.473012425210737 0.334476720920311 no 1137 0.318102157276319 363 24262820 SGTC_1178 0988-0033 191 µM 0.472784210026817 0.334558709408473 no 1138 0.318183570200058 346 5392207 SGTC_2694 st077685 81.9 µM 0.472438627753821 0.334682878165508 no 1139 0.318306869092622 321 2838096 SGTC_2580 diallyl disulphide 81.36 µM 0.471695952209301 0.334949784903263 no 1140 0.318571913384751 327 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2778 tioconazole 65.09 nM 0.471122846278281 0.335155807808772 no 1141 0.318776505561468 346 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1831 st055328 12 µM 0.471089109047356 0.335167937378978 no 1142 0.318788551084381 338 1103068 SGTC_1442 4112-3290 3 µM 0.470212247702466 0.335483256207444 no 1143 0.319101692310236 347 704353 SGTC_653 0203-0016 55.2 µM 0.469837399882952 0.335618086644235 no 1144 0.319235595881534 365 295302 SGTC_1391 3442-0225 151 µM 0.469423334964168 0.335767047833902 no 1145 0.319383536044897 354 5227075 SGTC_1396 3511-0007 98.6 µM 0.468000672165344 0.336279051911134 no 1146 0.319892054513638 358 X1396 SGTC_2681 menadione 3.18 µM 0.465544896311032 0.337163578929939 no 1147 0.32077064673212 363 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1118 chelidonine 707.474 nM 0.464714815118299 0.337462763471613 no 1148 0.32106784874081 348 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2171 5739187 198.077 µM 0.464551801320359 0.337521530296224 no 1149 0.321126227625301 322 2262761 SGTC_227 fluconazole 33.516 µM 0.464129314549591 0.337673856126924 no 1150 0.321277550155218 372 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3345 9148410 3.559 µM 0.463350714087351 0.337954646910057 no 1151 0.321556500021627 356 4903596 SGTC_908 3448-7491 47.7 µM 0.463002229668927 0.338080351906779 no 1152 0.321681384452867 311 1203031 SGTC_1965 Pectolinarigenin 58.4 µM 0.462881205533066 0.338124011852694 no 1153 0.321724759917274 353 5320438 An anti-inflammatory. SGTC_2157 5649910 96.377 µM 0.462825198294691 0.33814421742713 no 1154 0.321744833925648 344 2858091 SGTC_3112 9123419 49.47 µM 0.461946689074082 0.33846121571459 no 1155 0.32205977560113 363 17015854 SGTC_111 0083-0039 52.457 µM 0.461793535588715 0.338516490826024 no 1156 0.322114693540333 380 759313 SGTC_2144 5628481 200 µM 0.459669051265732 0.339283603624004 no 1157 0.322876893577083 334 2818399 SGTC_2418 pentamidine 31.67 µM 0.459001068723919 0.339524937913218 no 1158 0.323116699308143 336 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_926 2268-1401 59.4 µM 0.458507199053151 0.339703409583572 no 1159 0.323294045806915 345 2931578 SGTC_1199 1638-0010 4.46 µM 0.455692621623838 0.340721209859854 no 1160 0.324305514249059 350 3111136 SGTC_1272 0839-0021 27 µM 0.454842577695444 0.341028829122254 no 1161 0.324611248168048 381 5027250 SGTC_2705 st078069 42.8 µM 0.453232497280385 0.341611784786235 no 1162 0.3251906670898 350 1530061 SGTC_658 3253-0951 102 µM 0.451630891537464 0.342192047118079 no 1163 0.325767455883298 364 1184878 SGTC_133 0724-0033 378.92 µM 0.451420482186075 0.342268306236803 no 1164 0.325843261975996 350 280309 SGTC_2366 9070441 60.58 µM 0.451236701327005 0.342334919596151 no 1165 0.3259094802708 336 6837235 SGTC_413 propylparaben 100 µM 0.450417004143117 0.342632087410619 no 1166 0.326204893160249 335 7175 A pharmaceutical preservative. SGTC_3305 9127027 53.8275 µM 0.449666151520642 0.342904382253634 no 1167 0.326475590705376 356 41905295 SGTC_2338 7999974 200 µM 0.448036160845403 0.343495775086838 no 1168 0.327063549736943 370 315925 SGTC_2348 9022543 33.42 µM 0.445225369764211 0.344516485470731 no 1169 0.328078447265484 382 3162678 YDL140C RPO21 SGTC_145 3737-0113 38.366 µM 0.444386831572033 0.344821211945619 no 1170 0.328381466213463 384 6849351 SGTC_18 0111-0177 500 nM 0.444313085953289 0.344848016072606 no 1171 0.3284081207566 360 721752 SGTC_484 loperamide 105 µM 0.443753367623403 0.345051480805048 no 1172 0.328610453255417 340 3955 An opioid-receptor agonist. SGTC_1646 st011709 75.6 µM 0.443074413660693 0.34529834934334 no 1173 0.328855955683074 352 5757843 SGTC_3311 9131146 2.8755 µM 0.442785005052218 0.345403598705884 no 1174 0.328960625171878 354 4900406 YPR165W RHO1 SGTC_1071 trifluoperazine 6.31 µM 0.442564165329733 0.345483919632255 no 1175 0.329040504593805 392 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_320 4092-0846 5.34 µM 0.442441538132816 0.345528522992119 no 1176 0.329084863163235 359 1359356 SGTC_1880 MG-132 525 µM 0.442066002658706 0.345665130368671 no 1177 0.329220722518988 380 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1142 3253-1408 9.78 µM 0.43836184623959 0.347013654250807 no 1178 0.330561999863274 374 256655 SGTC_1529 apigenin 74 µM 0.438060908680355 0.347123298086473 no 1179 0.330671065476454 378 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1195 1502-0147 41.1 µM 0.437304407372171 0.347398978897548 no 1180 0.330945299722966 345 817940 SGTC_1534 6-azauridine 81.6 µM 0.43686800586433 0.347558047110733 no 1181 0.331103538002214 351 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1173 0443-0020 122 µM 0.436552754290158 0.347672972913923 no 1182 0.331217866338737 369 5331295 SGTC_425 3825-7017 13.1 µM 0.435680220694083 0.347991130335121 no 1183 0.331534379177204 407 3397440 SGTC_296 1222-0039 74.9 µM 0.435122430281321 0.348194577069391 no 1184 0.331736781535019 340 5984176 SGTC_1662 st014054 52 µM 0.434992714944574 0.34824189530061 no 1185 0.331783857673218 368 2838777 SGTC_952 1185-0122 232 µM 0.433527724929676 0.348776465780542 no 1186 0.332315714393656 354 678600 SGTC_3258 9138477 49.47 µM 0.432871868508783 0.349015883225536 no 1187 0.332553929080991 374 4970355 SGTC_276 colchicine 750 µM 0.431428118680605 0.349543129334952 no 1188 0.333078554039696 384 2833 A microtubule depolymerizer. SGTC_451 chloral hydrate 100 µM 0.430683946660491 0.34981500859919 no 1189 0.333349096488807 371 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3032 9089427 49.47 µM 0.43031347429492 0.349950387423037 no 1190 0.333483813416806 359 17173707 SGTC_767 0929-0023 86 µM 0.428010445590943 0.350792392503087 no 1191 0.334321757738219 371 1204563 SGTC_516 3992-2719 87.3 µM 0.427748835298895 0.350888085707109 no 1192 0.334416995539247 352 5350887 YDR037W KRS1 SGTC_3304 9125678 46.087 µM 0.426401724735621 0.351380988613247 no 1193 0.334907572422678 357 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2264 7948757 110.76 µM 0.423054362897773 0.352606857364479 no 1194 0.336127799112779 339 2971411 SGTC_1131 3454-3128 32.3 µM 0.422740059707782 0.352722040166588 no 1195 0.336242462243445 337 710982 SGTC_237 nikkomycin 200 µM 0.422559943392038 0.352788053543654 no 1196 0.336308178596177 372 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2286 7945697 125 µM 0.421771419846605 0.353077102848878 no 1197 0.336595934274558 359 1245733 SGTC_212 3807-4682 38.772 µM 0.421751523388838 0.35308439739668 no 1198 0.336603196322041 364 3125501 YBL034C STU1 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.421564024007411 0.353153142093309 no 1199 0.336671635084921 378 689007 SGTC_1225 1216-0074 20.6 µM 0.419902090820213 0.353762681869902 no 1200 0.337278490152197 359 4241466 SGTC_1975 st070967 30.8 µM 0.419858571007251 0.353778648482629 no 1201 0.337294387114254 394 261391 SGTC_1657 st012939 43.4 µM 0.419810997085234 0.353796102767081 no 1202 0.337311765297762 360 24207257 SGTC_1711 st032263 62.8 µM 0.418791057124039 0.354170380009942 no 1203 0.337684420573423 384 3958979 SGTC_760 0568-0725 82.9 µM 0.418697283381604 0.354204798308439 no 1204 0.337718690665129 380 3916171 SGTC_166 k072-0058 166.424 µM 0.418440573198607 0.354299026167736 no 1205 0.33781251359177 375 5846229 SGTC_1947 st076332 61.6 µM 0.417642091769573 0.354592173201972 no 1206 0.338104408512535 375 24208416 SGTC_1884 5633444 25 µM 0.416759403781051 0.354916335296209 no 1207 0.338427199492302 352 5724239 SGTC_1545 lovastatin 49.4 µM 0.416157828900319 0.355137320431072 no 1208 0.338647258028026 347 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3140 9094243 49.47 µM 0.416063058455139 0.355172138263937 no 1209 0.338681930467391 402 19291112 SGTC_3000 9075062 71.4286 µM 0.415015223945842 0.355557184036452 no 1210 0.339065379220121 353 17057871 SGTC_3312 9133330 71.43 µM 0.41440480092772 0.355781563031713 no 1211 0.339288836766269 384 17617324 SGTC_2432 5630864 12.22 µM 0.412697487375854 0.356409401654856 no 1212 0.339914132982572 374 5714970 SGTC_1447 4239-0816 81.9 µM 0.412145758706976 0.356612374819203 no 1213 0.34011629552559 356 1341554 SGTC_3041 9091929 49.47 µM 0.411351667699625 0.356904580936442 no 1214 0.340407344344906 369 25236887 SGTC_3102 9121669 49.47 µM 0.411294941465072 0.356925458022409 no 1215 0.340428139183897 381 41905072 SGTC_8 0354-0001 70 µM 0.410945250304304 0.357054165120944 no 1216 0.340556340519567 374 4993152 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.409677509199782 0.357520905388149 no 1217 0.34102126530225 371 616764 SGTC_2390 9097792 176.6 µM 0.409364688960213 0.357636108253865 no 1218 0.341136024546911 368 4497149 SGTC_2119 5528445 120.635 µM 0.409345657287465 0.357643117500516 no 1219 0.341143006859762 369 791935 SGTC_897 1000-0139 31.4 µM 0.409179172961357 0.357704434688632 no 1220 0.341204088709951 391 6151020 SGTC_2190 6049624 200 µM 0.408376321344182 0.358000181346328 no 1221 0.341498707337626 383 2265554 SGTC_2722 naftopidil 47.16 µM 0.408092741239537 0.358104664203701 no 1222 0.341602794472851 386 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.407963519721255 0.35815227838035 no 1223 0.341650228797543 394 688667 SGTC_2783 7738165 71.43 µM 0.406450916336103 0.358709790338025 no 1224 0.342205657398369 364 17201110 SGTC_2924 9010168 62.78 µM 0.406273216900241 0.358775306189494 no 1225 0.342270931148169 365 2993929 SGTC_45 0kpi-0036 14.9 µM 0.405760398486394 0.358964400060937 no 1226 0.34245932946856 392 2795021 SGTC_1876 myriocin 605 nM 0.405711557632773 0.358982411174965 no 1227 0.342477274580307 395 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_469 w7 172 µM 0.40566917518058 0.358998040868774 no 1228 0.342492847033668 374 45115570 A P450 inhibitor. SGTC_3207 9114163 49.47 µM 0.404052799395353 0.359594299796842 no 1229 0.343086946596003 410 849233 SGTC_1054 3429-0080 167 µM 0.402168555222417 0.360289803335149 no 1230 0.343779991146829 386 1162877 SGTC_2890 9046729 58.44 µM 0.401844931021396 0.360409304624503 no 1231 0.343899076408549 362 903329 SGTC_615 k087-0205 167 µM 0.401454432669864 0.360553517979368 no 1232 0.344042790230676 379 9642773 SGTC_2069 5228469 200 µM 0.39901967068117 0.361453136699123 no 1233 0.344939355141752 388 2835210 SGTC_1898 st060199 18.6 µM 0.399007370586921 0.361457683403509 no 1234 0.344943886684739 358 688866 SGTC_268 camptothecin 39.6153 µM 0.397468823153964 0.362026558368604 no 1235 0.345510886295844 380 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1235 benzylparaben 21.5 µM 0.39498600296974 0.362945219042937 no 1236 0.346426608943998 402 7180 SGTC_623 k072-0108 16.9 µM 0.394928287363384 0.362966583623962 no 1237 0.346447906525132 396 5382803 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.393925210588853 0.363337960531145 no 1238 0.346818128416086 352 16623 A steroid. SGTC_951 1171-0579 82.7 µM 0.39344546881606 0.363515624501 no 1239 0.346995246273333 379 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2117 5521686 200 µM 0.392315677273452 0.363934138947925 no 1240 0.347412490726473 371 803312 SGTC_2756 carbadox 75.1 µM 0.392271771680257 0.363950406401415 no 1241 0.34742870928222 365 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3340 9146634 11.102 µM 0.391178040825577 0.364355723486346 no 1242 0.347832819297822 390 4907387 SGTC_1146 3579-1023 7 µM 0.390881998017831 0.364465457765317 no 1243 0.347942230500988 388 X1146 SGTC_1922 5578187 25 µM 0.389461349443417 0.364992204427004 no 1244 0.348467448397194 357 1350412 SGTC_76 0433-0009 400.328 µM 0.389233420976879 0.365076739269275 no 1245 0.348551741294648 410 2841569 SGTC_2723 salbutamol 83.58 µM 0.388772866718816 0.365247571121154 no 1246 0.348722087081131 383 9884233 β2-adrenoceptor agonist SGTC_2425 5628681 7.85 µM 0.388311793927993 0.365418622098778 no 1247 0.348892655212818 379 5714958 SGTC_2575 plumbagin 510 nM 0.385853302195747 0.366331136255693 no 1248 0.349802658422932 368 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1255 0566-0045 221 µM 0.38571931258368 0.366380890729335 no 1249 0.349852279128804 394 2788469 SGTC_960 1222-0186 7.7 µM 0.384647114249199 0.366779111859112 no 1250 0.35024944130839 391 3126296 SGTC_964 1287-0107 19.4 µM 0.383646014501884 0.367151056018254 no 1251 0.350620415153496 382 51516812 YPR165W RHO1 SGTC_502 l-744,832 89.3 µM 0.381593564570019 0.367914003770564 no 1252 0.351381429197676 417 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2537 larixol 68.93 µM 0.379100697842673 0.368841366663516 no 1253 0.352306544053777 383 6708759 SGTC_866 0495-0101 262 µM 0.378456508436328 0.369081133847093 no 1254 0.352545748265385 391 635694 SGTC_3142 9086498 49.47 µM 0.376805410407666 0.369695904686688 no 1255 0.353159109845943 397 25236367 SGTC_1436 4092-1007 8.32 µM 0.374072500668391 0.370714209578023 no 1256 0.354175188615202 358 2881121 SGTC_2139 5578692 56.4705 µM 0.370488164194671 0.372051136134426 no 1257 0.35550939687967 376 650991 YMR113W FOL3 SGTC_840 0245-0196 390 µM 0.367842384768831 0.373038980528616 no 1258 0.356495381439197 377 3827528 SGTC_483 fpl-64176 144 µM 0.367465050860925 0.373179932433658 no 1259 0.356636078254101 404 3423 SGTC_1859 st055998 20 µM 0.367149241923453 0.373297914927124 no 1260 0.356753849199317 378 676301 SGTC_1171 0368-0077 21.4 µM 0.366675461489858 0.37347493598503 no 1261 0.356930556220909 404 3239779 SGTC_1062 mesoridazine 14.2 µM 0.365902529834249 0.373763787778152 no 1262 0.357218904272019 383 4078 A neuroleptic. SGTC_344 k064-0035 6.43 µM 0.365350187094097 0.373970246886244 no 1263 0.357425009921411 398 5088750 SGTC_640 3381-0960 37.1 µM 0.364959637260993 0.374116251568723 no 1264 0.357570767960595 384 1745025 SGTC_244 nsc-207895 1.295 µM 0.363356476918838 0.374715772333537 no 1265 0.358169304756036 381 42640 SGTC_743 1275-0778 158 µM 0.361554849387603 0.375389873726974 no 1266 0.358842355021035 407 2849257 YMR203W TOM40 SGTC_1967 st070177 51.4 µM 0.359833710736591 0.376034214800636 no 1267 0.359485745962003 417 5729214 SGTC_2437 5741531 144.16 µM 0.359288695588566 0.376238323775975 no 1268 0.359689565078247 410 2262990 SGTC_896 0964-0007 44.5 µM 0.35802365706673 0.376712215907071 no 1269 0.360162804830099 387 6756758 SGTC_49 0717-0965 32.132 µM 0.355887960592632 0.377512683871262 no 1270 0.360962236183019 402 5889349 YGL099W LSG1 SGTC_1356 1502-0781 85.8 µM 0.355740884600822 0.377567827981125 no 1271 0.361017311900428 379 567702 SGTC_2033 5192550 145 µM 0.355126971338588 0.377798033211107 no 1272 0.36124723581913 359 182073 SGTC_32 0928-0142 34.1 µM 0.354479500300564 0.378040868969075 no 1273 0.361489782174217 408 2244242 SGTC_618 k072-0232 33.2 µM 0.352554955942729 0.378762958700445 no 1274 0.362211055846116 410 5872756 YGL099W LSG1 SGTC_665 3914-0008 307 µM 0.352404496581921 0.378819428983624 no 1275 0.36226746511614 386 1069549 SGTC_3030 9087619 49.47 µM 0.35180414774667 0.379044777157147 no 1276 0.362492573863075 392 25236973 SGTC_1384 3089-0840 101 µM 0.350353794658984 0.379589354184782 no 1277 0.363036599015826 361 1069836 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.350237944731352 0.379632863711126 no 1278 0.363080066079498 378 5355888 SGTC_1226 3909-7979 35.4 µM 0.348037435601464 0.38045959336914 no 1279 0.363906034682191 390 6615510 SGTC_301 4119-0100 24.5 µM 0.347553658681875 0.380641421385194 no 1280 0.364087706975424 415 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_912 3474-0017 2.18 µM 0.345299953211247 0.381488825685817 no 1281 0.364934440920641 415 3360550 SGTC_55 0767-0285 6.563 µM 0.345276343292325 0.381497706146505 no 1282 0.364943314838807 409 3116166 SGTC_3281 9140613 49.47 µM 0.345044898135773 0.381584763522365 no 1283 0.365030308606337 357 16013766 SGTC_375 3970-0961 9.27 µM 0.344929702711493 0.381628096156095 no 1284 0.36507360993741 375 2898222 SGTC_1032 k061-1018 98.7 µM 0.343972704889072 0.381988143771724 no 1285 0.365433406667482 388 4005393 SGTC_657 3534-0529 86.7 µM 0.343599589478304 0.38212854722855 no 1286 0.365573716741539 406 1049549 SGTC_356 1634-0012 32.5 µM 0.343010622508477 0.382350207242711 no 1287 0.365795234411375 427 735457 SGTC_1765 st044815 90.4 µM 0.342897296128621 0.38239286249291 no 1288 0.365837862983264 391 645695 SGTC_1296 1068-0102 11.9 µM 0.341454137276671 0.382936181943262 no 1289 0.366380862764391 407 767053 SGTC_1431 4049-0260 9.09 µM 0.341399122078992 0.382956898592875 no 1290 0.366401567964121 396 3854841 SGTC_1466 k213-0079 57.5 µM 0.340579218219516 0.383265683125485 no 1291 0.366710188265693 411 3657981 SGTC_898 1000-0849 28.3 µM 0.340252118137717 0.383388893213079 no 1292 0.366833336185626 420 6751807 SGTC_1189 1431-2119 7.28 µM 0.340207415291618 0.383405732528114 no 1293 0.366850167153078 401 3107275 SGTC_1212 0520-0165 585 µM 0.338831971294767 0.383923962183545 no 1294 0.367368157419176 419 5403258 SGTC_1609 st001574 46.4 µM 0.338730179888001 0.383962322662885 no 1295 0.367406501525911 444 3960012 SGTC_1303 1160-0052 261 µM 0.33814023775804 0.384184666979213 no 1296 0.367628754599995 401 3562476 SGTC_1669 st015249 58.4 µM 0.336689936031029 0.384731435626286 no 1297 0.36817532538313 411 722793 SGTC_3254 9136651 49.47 µM 0.335467167520608 0.385192601729878 no 1298 0.368636353878288 429 16454030 SGTC_1791 st048313 56.1 µM 0.334363264333488 0.385609077401619 no 1299 0.369052728276392 401 1204976 SGTC_1393 3470-5649 58.2 µM 0.33416441870224 0.385684111030105 no 1300 0.369127745978124 411 4108395 SGTC_132 0417-1715 25.805 µM 0.333648964886376 0.385878635441713 no 1301 0.369322232395298 425 6769098 SGTC_2205 7238770 200 µM 0.332481324495976 0.386319391195551 no 1302 0.369762919650521 406 279867 SGTC_868 0527-0199 213 µM 0.332447117365591 0.386332305767526 no 1303 0.369775832583308 373 2849450 SGTC_2485 5633444 17.78 µM 0.331202856253372 0.386802150030307 no 1304 0.370245631443944 376 5724239 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.330384934766414 0.387111095035147 no 1305 0.370554561684163 377 5711223 A potent inhibitor of glutathione S-transferases. SGTC_421 streptovitacin 30 mM 0.329582547511345 0.387414241961481 no 1306 0.370857705751173 390 91467 include heat shock SGTC_229 benomyl 22.8748 µM 0.329506132132865 0.387443115753414 no 1307 0.37088657987127 397 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1143 3454-2408 5.08 µM 0.329424132210652 0.387474100375346 no 1308 0.370917564961502 394 X1143 SGTC_2911 7942208 15.64 µM 0.328273726456172 0.387908870015299 no 1309 0.371352353849163 385 1243384 SGTC_394 menadione 8.33 µM 0.325018686137343 0.389139798131152 no 1310 0.372583464663235 425 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1907 st060210 83.7 µM 0.324934085875249 0.389171805518583 no 1311 0.372615479325878 428 688793 SGTC_2088 5278280 127.392 µM 0.323418373455068 0.389745382457127 no 1312 0.373189208302671 381 791502 SGTC_1932 st074806 40.9 µM 0.322336924255066 0.390154772119648 no 1313 0.373598731564684 438 17251235 SGTC_1331 1472-0049 76.2 µM 0.321492117337417 0.390474664100338 no 1314 0.373918742466124 399 24051409 SGTC_3188 9110789 49.47 µM 0.321106523267878 0.390620696621991 no 1315 0.374064833510273 405 849217 SGTC_2643 anethole 100 µM 0.320152091233294 0.390982226274793 no 1316 0.374426519459523 436 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1911 st060208 74.3 µM 0.320137286632807 0.39098783485771 no 1317 0.374432130595172 400 688783 SGTC_562 3772-2733 112 µM 0.320014781013681 0.391034245823168 no 1318 0.374478562834537 430 2876874 YIL048W NEO1 SGTC_1283 0922-0125 16.4 µM 0.319461059577705 0.391244041236211 no 1319 0.374688457754348 404 3360884 SGTC_2383 9036125 200 µM 0.319171618235663 0.391353718120598 no 1320 0.374798188835943 412 79580 SGTC_455 paf C-16 10 µM 0.317600402491285 0.391949243323238 no 1321 0.37539403439639 411 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2419 paclitaxel 166.5 µM 0.315900066715157 0.392593993123774 no 1322 0.376039180642188 407 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1930 st074634 34.3 µM 0.313892214843353 0.393355729450355 no 1323 0.376801451717881 386 684253 YOR116C RPO31 SGTC_1789 tunicamycin 25 nM 0.313817679748018 0.393384014361031 no 1324 0.376829757867877 420 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1751 st044839 27.194 µM 0.313347722575665 0.393562368759986 no 1325 0.37700824847366 381 5291326 SGTC_2772 vinpocetine 57.06 µM 0.311639545312802 0.394210830441234 no 1326 0.377657238516518 439 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_738 1315-0003 72.4 µM 0.311347157309532 0.3943218568148 no 1327 0.377768360562225 425 6251474 SGTC_1899 st063254 59.6 µM 0.310392620349676 0.394684375933534 no 1328 0.378131202661976 390 3093813 SGTC_1575 cyproterone acetate 48 µM 0.309253568911519 0.395117090287114 no 1329 0.378564323762235 422 9880 An androgen receptor antagonist and liver toxin. SGTC_2459 5811157 9.22 µM 0.30903668114963 0.395199498477607 no 1330 0.378646812032471 404 2870684 YBR192W RIM2 SGTC_1959 st077091 55.8 µM 0.308848752136748 0.395270907356964 no 1331 0.378718290979904 397 821356 YKL052C ASK1 SGTC_2378 9074213 121.43 µM 0.308808369213671 0.395286252436076 no 1332 0.378733651197996 415 657714 SGTC_3302 9125395 16.351 µM 0.304799598197188 0.396810346990231 no 1333 0.380259393783239 414 17599668 SGTC_1746 st038117 42 µM 0.299856212793692 0.398691942798484 no 1334 0.382143417682146 426 2898218 SGTC_1863 st057641 20.1 µM 0.298318695862729 0.399277648964128 no 1335 0.382729968163185 434 3921635 SGTC_208 k072-0098 12.366 µM 0.297841619078647 0.399459434147077 no 1336 0.382912023924111 395 5948901 SGTC_1546 5-methoxyflavanone 78.7 µM 0.295874708880465 0.400209134772605 no 1337 0.383662883084582 411 147795 SGTC_1203 3992-3522 103 µM 0.295457374903697 0.40036825173664 no 1338 0.38382225476083 435 5322312 SGTC_1635 st007035 42.4 µM 0.294019736539513 0.400916506701924 no 1339 0.384371411006455 389 3716403 SGTC_2191 5911152 200 µM 0.293422137013625 0.401144463592024 no 1340 0.384599753416153 411 2875902 SGTC_2482 5981709 142.65 µM 0.293150580001427 0.4012480613002 no 1341 0.384703528419579 426 877755 SGTC_2821 7996764 71.43 µM 0.291861231466182 0.401740036255448 no 1342 0.385196363161798 367 2987135 SGTC_2917 7979103 53.79 µM 0.291380534225576 0.401923495146902 no 1343 0.38538015020673 414 2980565 SGTC_391 gliotoxin 8.33 µM 0.29035336893605 0.40231558685201 no 1344 0.385772956962684 417 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1389 3405-0187 19 µM 0.288415006663764 0.4030557700917 no 1345 0.386514540952465 425 799890 SGTC_1065 prochlorperazine maleate 2.48 µM 0.28737836871554 0.403451763573629 no 1346 0.386911311119135 450 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_214 4373-3496 70 µM 0.286783529744545 0.403679035522928 no 1347 0.387139037414636 441 3779166 SGTC_3355 9151058 44.0485 µM 0.286511707576358 0.403782902284735 no 1348 0.387243113903054 399 17015728 SGTC_3126 9127922 49.47 µM 0.285923309351389 0.404007760078937 no 1349 0.387468430203434 446 45595682 SGTC_1944 st076371 56.9 µM 0.284497811340824 0.404552648948597 no 1350 0.388014455535228 436 24208455 SGTC_1795 st049545 62.3 µM 0.283909994651297 0.404777392665963 no 1351 0.388239678456089 409 5291882 SGTC_1229 0139-0193 12.2 µM 0.283520938900533 0.404926160123738 no 1352 0.388388766477532 417 3090752 SGTC_1675 st018485 24.5 µM 0.281250938838852 0.405794437944582 no 1353 0.389258968589804 407 3323024 SGTC_2844 9010103 25.97 µM 0.280725268287723 0.405995573852454 no 1354 0.389460563237532 433 2480525 SGTC_3350 9150499 3.57 µM 0.277314684463822 0.407301156900054 no 1355 0.390769242500254 433 4910996 YPR165W RHO1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.276243416529406 0.407711455262193 no 1356 0.391180556253269 392 16486 A toxic proline analog. SGTC_1418 3966-3099 2.4 µM 0.275711551756535 0.407915198472539 no 1357 0.391384811197606 436 740335 SGTC_1844 rapamycin 4 nM 0.275093084245034 0.408152148196348 no 1358 0.391622362330394 408 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2320 7373003 200 µM 0.274741585041679 0.408286830940361 no 1359 0.391757389921541 396 5415828 SGTC_3087 9117406 49.47 µM 0.274613403283834 0.408335948601712 no 1360 0.39180663388758 372 42546093 SGTC_2506 ethyl hematommate 54.16 µM 0.274602499843604 0.40834012673138 no 1361 0.391810822774554 414 3940691 An allergen. SGTC_2627 acetyl isogambogic acid 100 µM 0.273683581048625 0.408692288028744 no 1362 0.392163898299954 412 6857789 A caspase activator and apoptosis inducer. SGTC_2081 5214970 32.255 µM 0.273210236135956 0.408873718875868 no 1363 0.392345805956602 414 2063512 SGTC_3158 9100007 49.47 µM 0.273016931158492 0.408947817369544 no 1364 0.392420100320022 403 19297233 SGTC_1942 st076330 65.2 µM 0.272683483534088 0.409075643590982 no 1365 0.392548265980477 435 24208414 SGTC_1021 4476-0760 85.3 µM 0.27195537417893 0.409354795884562 no 1366 0.392828166362317 412 746768 SGTC_591 4299-0174 154 µM 0.271680425033578 0.409460221526392 no 1367 0.392933876958248 434 5509088 SGTC_2397 5161689 200 µM 0.269999891080871 0.410104742265953 no 1368 0.393580168699083 413 2259942 SGTC_2690 usnic acid 100 µM 0.269665054922301 0.410233188177054 no 1369 0.393708973490576 434 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2916 7875993 68.79 µM 0.269592489119401 0.410261026287578 no 1370 0.393736889641449 436 1299250 SGTC_127 0180-0333 59.125 µM 0.269149161748546 0.410431107897845 no 1371 0.393907450064555 405 771601 SGTC_685 1278-0033 54.9 µM 0.267869366874775 0.410922192907278 no 1372 0.394399936973859 454 3590572 SGTC_981 1488-1094 54.9 µM 0.266069880779245 0.411612930756362 no 1373 0.395092695403541 406 3449522 SGTC_1282 0886-0010 32.4 µM 0.265815453119087 0.411710615696007 no 1374 0.3951906706898 448 2836211 YNL267W PIK1 SGTC_1395 3486-0190 4.35 µM 0.264388503244544 0.412258579985176 no 1375 0.395740284764132 427 6748079 SGTC_1652 st011932 78 µM 0.264199344707662 0.412331231789336 no 1376 0.395813157990707 431 1551076 SGTC_2966 9084041 48.03 µM 0.262909056459587 0.412826884303466 no 1377 0.396310337881761 399 17741380 SGTC_3296 9122258 64.045 µM 0.26253295081994 0.412971388071113 no 1378 0.396455292448265 433 4730474 SGTC_473 2-arachidonoylglycerol 10 µM 0.261769952750583 0.413264576214924 no 1379 0.396749402861871 428 5282280 An endocannabinoid. SGTC_2729 fluphenazine 10.66 µM 0.259739764462299 0.414044927574447 no 1380 0.397532258711676 438 3372 An atypical antipsychotic. SGTC_82 0054-0107 293.755 µM 0.259716791334503 0.414053759793144 no 1381 0.397541119690664 412 3104697 SGTC_2923 7992654 58.14 µM 0.256353370192139 0.415347323096811 no 1382 0.398838995101862 443 2985126 SGTC_1052 3253-3998 198 µM 0.255478867193186 0.41568380569969 no 1383 0.39917663185776 413 5450317 SGTC_3154 9100113 49.47 µM 0.255365559460147 0.415727407656854 no 1384 0.399220384352388 409 25237525 SGTC_3063 1327-0034 4 µM 0.251582652109043 0.41718370083312 no 1385 0.400681834511142 457 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_879 0831-1030 162 µM 0.251355044283911 0.417271358714486 no 1386 0.400769810793255 443 1549252 SGTC_15 0266-0086 27.098 µM 0.249938591430921 0.417816964975812 no 1387 0.40131741923509 451 1712902 YIL048W NEO1 SGTC_943 3253-1379 105 µM 0.248829276454449 0.41824437473382 no 1388 0.401746421934372 450 668464 SGTC_1754 st042065 16.137 µM 0.248748660935374 0.418275438986853 no 1389 0.401777602801274 433 1126236 YIL048W NEO1 SGTC_1686 st019653 115.5 µM 0.246638653662163 0.419088686481025 no 1390 0.402593943582816 460 97252 SGTC_691 1548-0686 185 µM 0.246105102018057 0.419294385020138 no 1391 0.402800436842903 458 46495133 SGTC_213 1246-0773 967 nM 0.244146501084699 0.420049667170193 no 1392 0.403558679661194 443 6251622 SGTC_266 formosanin C 406 nM 0.243738142062841 0.420207177121539 no 1393 0.40371681547979 433 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1339 1486-1321 22.7 µM 0.243055247157792 0.420470608057186 no 1394 0.40398129966235 431 3469382 SGTC_1190 1486-1332 13 µM 0.238737078873498 0.422137188330628 no 1395 0.405654731580179 456 4150046 SGTC_2789 5281112 71.43 µM 0.238245173733838 0.422327126284439 no 1396 0.405845471026425 433 765948 SGTC_3255 9139072 49.47 µM 0.236796028811908 0.422886785389507 no 1397 0.406407516251697 415 17646060 SGTC_2880 9042983 58.44 µM 0.236173625434952 0.423127205142953 no 1398 0.406648972264132 437 6464714 SGTC_2765 myclobutanil 7.74 µM 0.235471357998281 0.423398508872013 no 1399 0.406921453463611 456 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_993 3909-8757 62.7 µM 0.235223511515627 0.423494266935043 no 1400 0.407017629169649 407 4288324 YLR208W SEC13 SGTC_2131 toluylene red 5.2905 µM 0.234711506565146 0.423692099669365 no 1401 0.407216328123628 399 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2249 haloperidol 116.36 µM 0.234235050249258 0.423876214106034 no 1402 0.407401252809827 458 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2871 9038510 12.99 µM 0.234041199998225 0.423951127368113 no 1403 0.407476496879606 471 4945164 SGTC_2676 harmalol 100 µM 0.234026753041887 0.423956710491983 no 1404 0.407482104684026 425 5459187 A monoamine oxidase inhibitor SGTC_2993 9054257 71.4286 µM 0.233321995253334 0.42422908741221 no 1405 0.407755690070445 454 6470217 YGL055W OLE1 SGTC_2868 9035608 32.47 µM 0.231951083274005 0.424759025185156 no 1406 0.408288003776571 433 6462614 SGTC_2124 5246320 200 µM 0.231534895182758 0.424919933216519 no 1407 0.408449639689349 449 579342 SGTC_842 0271-0008 11.1 µM 0.23112490027763 0.425078459050055 no 1408 0.408608885570883 444 1221709 SGTC_1518 st038567 90.8 µM 0.230293349721511 0.425400017895801 no 1409 0.408931913952204 464 77966 SGTC_1985 st071382 65.5 µM 0.229739489385651 0.42561422206906 no 1410 0.409147103709659 436 6123237 SGTC_1233 0325-0408 14.2 µM 0.228067294119794 0.426261072587256 no 1411 0.409796962795022 456 12874 SGTC_2867 9039098 71.43 µM 0.22733030147854 0.426546224447221 no 1412 0.410083456333183 440 6463460 SGTC_2704 st078022 71.1 µM 0.227250731259891 0.426577013479786 no 1413 0.410114390795952 449 54697681 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.227014542289394 0.426668407466784 no 1414 0.41020621712399 427 23847180 SGTC_63 0099-0242 26.702 µM 0.225577875591282 0.427224414331036 no 1415 0.410764875031979 440 3898502 YLR359W ADE13 SGTC_2066 5222451 176 µM 0.225137782109956 0.42739476465322 no 1416 0.410936044746265 459 2281147 SGTC_534 k292-0788 63.4 µM 0.22273177151756 0.428326315931958 no 1417 0.411872136168065 463 4146317 SGTC_3326 9140064 16.379 µM 0.222201339061963 0.428531740959219 no 1418 0.412078575876171 433 1868434 SGTC_1587 estradiol valerate 56.1 µM 0.221981038744365 0.428617064206247 no 1419 0.412164322002604 459 13791 A steroid. SGTC_2049 5262831 67.185 µM 0.221160257095844 0.428934985760096 no 1420 0.412483826637434 441 763417 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.220960083841771 0.429012527867974 no 1421 0.412561756632741 401 6708561 SGTC_2949 9072542 2.23 µM 0.220508267988906 0.429187560085971 no 1422 0.412737666960205 424 16457352 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.220040885897761 0.429368637273619 no 1423 0.412919656301123 429 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3151 9099821 49.47 µM 0.219842532327796 0.429445489613388 no 1424 0.41299689691712 424 17174189 SGTC_1723 st034307 2.5525 µM 0.219511990841281 0.429573564267104 no 1425 0.413125620146499 432 867466 SGTC_2988 9073640 71.4286 µM 0.217952861869459 0.43017777848775 no 1426 0.413732919614014 457 9102229 SGTC_1674 st016616 23.6 µM 0.217238133467458 0.430454814216173 no 1427 0.414011383996152 418 625830 SGTC_144 4161-2749 112.381 µM 0.216934404352753 0.430572552968508 no 1428 0.4141297325922 437 797501 YMR168C CEP3 SGTC_872 0588-0139 234 µM 0.216809542848041 0.430620956565571 no 1429 0.414178387364602 414 2047100 SGTC_1256 0570-0116 285 µM 0.214093019666285 0.431674296099472 no 1430 0.415237259551365 430 410638 SGTC_733 4069-0007 56.1 µM 0.213627549362626 0.431854832503833 no 1431 0.415418757009296 460 5717425 YNL287W SEC21 SGTC_2053 5265679 138 µM 0.213266079725732 0.431995041232595 no 1432 0.415559714693929 447 764595 SGTC_905 2-aminofluorene 215 µM 0.213160456922938 0.432036012374456 no 1433 0.415600905117881 431 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1124 fisetin 1.16336 µM 0.212779955005078 0.432183615329253 no 1434 0.415749299655918 430 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_965 1291-5240 308 µM 0.212070096110103 0.432459006562379 no 1435 0.416026174467925 447 2834598 SGTC_2862 9027634 71.43 µM 0.211449113885412 0.4326999448206 no 1436 0.416268417828758 452 5012562 SGTC_1139 k015-0024 46.9 µM 0.209454850011074 0.433473878857765 no 1437 0.417046589040137 456 2766652 SGTC_1057 3448-5381 134 µM 0.208729114803448 0.433755585699792 no 1438 0.41732985519657 449 5497911 SGTC_2315 7733312 200 µM 0.207661785248948 0.434169949476931 no 1439 0.417746529059754 420 726316 SGTC_1460 k062-0059 9.15 µM 0.207073956783759 0.434398189972608 no 1440 0.417976050378086 421 1373085 SGTC_17 0960-0276 49.807 µM 0.206322463570425 0.434690009626787 no 1441 0.418269516307144 449 6821114 SGTC_1279 0874-0590 65.2 µM 0.205666234712606 0.434944865360442 no 1442 0.418525817736542 445 3523074 SGTC_60 0986-0278 202 µM 0.20494118128781 0.435226481513341 no 1443 0.418809040002389 466 3110598 SGTC_1028 k015-0029 4.8 µM 0.204717883347209 0.435313218721845 no 1444 0.418896273711831 468 4588309 SGTC_1023 4482-3888 16 µM 0.20341609893632 0.435818941938077 no 1445 0.4194049088592 463 3303168 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.203130170504627 0.43593003482303 no 1446 0.419516645314474 423 641818 YHR062C RPP1 SGTC_1581 himbacine 57.9 µM 0.203099285329767 0.435942035062748 no 1447 0.419528715156673 450 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1087 pterostilbene 9.05 µM 0.202635840043222 0.436122110878941 no 1448 0.419709837397705 448 5281727 Similar to reservatol, lowers cholesterol. SGTC_2682 pyrogallin 40.03 µM 0.202428381069175 0.436202725213918 no 1449 0.419790921380474 446 822798 An ATP competetive kinase inhibitor. SGTC_1617 st002906 78 µM 0.202424803553832 0.436204115386822 no 1450 0.419792319658818 466 5150859 SGTC_2715 st079500 56.4 µM 0.199894171032487 0.437187680581724 no 1451 0.420781674643338 463 28246688 SGTC_1197 1601-0112 267 µM 0.19890303525535 0.437573005325543 no 1452 0.421169297582643 472 7350313 SGTC_885 0865-0106 16.8 µM 0.196010517880503 0.438697869143364 no 1453 0.422300966803549 449 2793380 SGTC_1243 0416-0003 5.65 µM 0.195774459851299 0.438789691141827 no 1454 0.422393350654695 451 2141977 SGTC_901 1112-0062 60.1 µM 0.194648045627021 0.439227889727393 no 1455 0.422834243697521 466 1908457 SGTC_1159 4092-0538 61.2 µM 0.194096245851144 0.439442578543027 no 1456 0.423050260554171 441 717301 SGTC_2591 skatole 100 µM 0.190719757990519 0.440756654803677 no 1457 0.424372579092872 467 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_867 0518-0118 155 µM 0.190159233829244 0.440974865592865 no 1458 0.424592177444115 478 6848158 SGTC_404 fumagillin 50 µM 0.188874239289649 0.441475178594483 no 1459 0.425095692116101 440 12015870 A methionine aminopeptidase binder. SGTC_894 0960-0238 55.9 µM 0.187165482628787 0.442140628052967 no 1460 0.425765443718864 481 6741907 YDL195W SEC31 SGTC_567 1080-0542 68.4 µM 0.186925799967282 0.442233981946134 no 1461 0.425859405135172 467 5950415 SGTC_1116 jasmonic acid  1.58368 µM 0.185965164836432 0.442608171439779 no 1462 0.42623603960124 474 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2354 9060492 162 µM 0.184938425008048 0.44300816683681 no 1463 0.426638666001887 455 6471895 SGTC_792 4534-1957 155 µM 0.184098465166341 0.443335440052496 no 1464 0.426968105260659 438 1717904 SGTC_607 4491-0986 66.8 µM 0.181541462018157 0.444331961205232 no 1465 0.427971295901391 458 698981 YDR232W HEM1 SGTC_2797 7859098 81.82 µM 0.181422678103881 0.444378262550388 no 1466 0.428017909839218 447 972681 SGTC_2409 alverine citrate 63.97 µM 0.181053512009451 0.444522166395374 no 1467 0.428162786751474 386 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1286 0929-0070 131 µM 0.180891402622032 0.444585360220514 no 1468 0.428226408622096 441 1420408 SGTC_1803 st050068 52.4 µM 0.180500862314798 0.444737607252458 no 1469 0.428379688742234 473 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_821 1114-0266 29.2 µM 0.180476901785662 0.4447469482171 no 1470 0.428389093175533 463 3123235 SGTC_513 4245-1575 41.7 µM 0.178119888241819 0.44566597441766 no 1471 0.429314411612704 454 719745 SGTC_2907 7721985 69.9 µM 0.176632250110437 0.446246171965965 no 1472 0.429898630218085 445 3267881 SGTC_1843 st055809 45.5 µM 0.176150493530088 0.446434087814573 no 1473 0.430087856482616 445 16413835 SGTC_2082 5219693 150 µM 0.174690923331826 0.447003486716598 no 1474 0.430661250118744 475 2834649 SGTC_1249 0481-0015 10.2 µM 0.17382234403016 0.447342383674955 no 1475 0.43100254185375 481 4227577 SGTC_165 k038-0023 64.381 µM 0.173243444948665 0.447568276345485 no 1476 0.43123003788313 452 46368543 SGTC_560 2332-1943 155 µM 0.172609335048452 0.44781573238868 no 1477 0.431479256867672 491 21177716 SGTC_2661 dactinomycin 12.96 µM 0.1725764321084 0.447828573038791 no 1478 0.431492189184151 465 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_731 3966-0296 387 µM 0.172149857967318 0.447995052142636 no 1479 0.431659858405911 460 660956 SGTC_1745 st081495 74 µM 0.171948289093036 0.448073721622464 no 1480 0.431739091348502 467 13842402 YBL026W LSM2 SGTC_2108 5365811 200 µM 0.171212867684658 0.44836076348925 no 1481 0.4320281949704 446 780283 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.170928782254672 0.448471651942103 no 1482 0.432139882365388 483 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_192 3455-0609 60.9 µM 0.16882179534521 0.449294207517224 no 1483 0.43296840709178 451 3769639 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.168057943564326 0.449592464877232 no 1484 0.433268847436629 475 61125 An anti-inflammatory. SGTC_1166 k206-0078 225 µM 0.16689070410296 0.450048285949958 no 1485 0.433728023810134 431 5404595 SGTC_3165 9101544 49.47 µM 0.164545668380241 0.450964249267308 no 1486 0.434650799239401 479 5002184 SGTC_2611 pyromycin 23.93 µM 0.163468425476757 0.451385104681897 no 1487 0.435074815774724 448 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_624 k048-0052 28 µM 0.163044281400354 0.451550823584794 no 1488 0.435241784803933 449 6835531 SGTC_1013 4112-3890 241 µM 0.162893522914421 0.4516097290266 no 1489 0.435301135340384 461 705171 SGTC_930 2810-3379 265 µM 0.161111797967404 0.452305977788809 no 1490 0.436002674101332 470 1015764 SGTC_335 4077-0256 27.6 µM 0.160728757394321 0.452455678667156 no 1491 0.436153519386719 484 3121989 SGTC_2436 5633522 8.09 µM 0.160557553473341 0.452522591200207 no 1492 0.43622094424184 463 5724242 SGTC_3067 9117431 49.47 µM 0.160093280886032 0.452704052089415 no 1493 0.436403796993046 471 17150885 SGTC_2168 5727979 200 µM 0.159891923358109 0.452782755730237 no 1494 0.4364831054464 479 695210 SGTC_2455 5377712 9.75 µM 0.159875110996219 0.452789327180581 no 1495 0.436489727427201 472 2243908 SGTC_714 4296-0578 26.1 µM 0.158360492561664 0.453381399146997 no 1496 0.437086371632108 471 1589775 SGTC_1694 st024011 44.9 µM 0.157850414522354 0.453580814612719 no 1497 0.437287335779561 478 2787533 SGTC_290 2043-6722 48.1 µM 0.157567316284713 0.453691497175949 no 1498 0.437398879808051 476 773758 YLR208W SEC13 SGTC_1360 1598-0022 39.8 µM 0.157446921493084 0.453738568867374 no 1499 0.437446318277582 482 761525 SGTC_1570 verbenone 133 µM 0.156196044454053 0.454227672358418 no 1500 0.437939247268951 487 29025 A natural terpanoid with antifungal properties. SGTC_1906 st060206 94.7 µM 0.156161860838189 0.45424103941883 no 1501 0.43795271924925 477 5133468 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.155147620798189 0.454637668371157 no 1502 0.438352470350987 485 676296 Flavone; oxidizing agent. SGTC_1504 k297-0033 30 µM 0.154073268780978 0.455057854052613 no 1503 0.438775982503525 440 4388117 SGTC_96 0929-0093 37.281 µM 0.153494493109482 0.455284237649606 no 1504 0.439004166355737 451 6991579 SGTC_1727 st034309 9.9045 µM 0.153457668432974 0.455298641827197 no 1505 0.439018685269411 495 870305 SGTC_549 1661-1316 519 µM 0.152641068289567 0.455618074594136 no 1506 0.439340668330737 479 2857282 SGTC_2710 st078562 53.7235 µM 0.151470253315635 0.456076117013389 no 1507 0.439802387244073 491 17250908 SGTC_256 clotrimazole 625 nM 0.15142632752571 0.456093302657804 no 1508 0.439819711278174 474 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2423 st077119 87.2 µM 0.151240916992354 0.456165844079228 no 1509 0.439892837206353 471 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2301 7769476 200 µM 0.150934900251832 0.456285575581374 no 1510 0.440013534715717 451 977820 SGTC_1552 6-methylflavone 10.6 µM 0.15065840807135 0.45639375877652 no 1511 0.440122592098193 501 689013 SGTC_625 k213-0058 121 µM 0.149918765805321 0.456683174740302 no 1512 0.440414353035724 485 3655420 SGTC_2603 homopterocarpin 100 µM 0.149694116248415 0.456771082829577 no 1513 0.440502975213785 462 101795 A weak amylase inhibitor. SGTC_1784 st039334 36.3 µM 0.148619651259649 0.457191563160617 no 1514 0.44092688288018 499 3496984 SGTC_2623 humulene 100 µM 0.147978870550708 0.457442348652306 no 1515 0.441179721749411 459 6187145 An anti-inflammatory. SGTC_2706 st078239 82.5 µM 0.14773653678663 0.457537196429061 no 1516 0.441275347914929 491 15434492 SGTC_2322 7413319 38.22 µM 0.147456266678442 0.457646895246961 no 1517 0.441385948228577 476 1840400 SGTC_2679 rapamycin 1 nM 0.147248968862429 0.457728034500287 no 1518 0.441467755125299 471 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2116 5511452 16.8835 µM 0.146327015540321 0.458088921171317 no 1519 0.441831620034545 485 870744 SGTC_2002 4023503 131 µM 0.145221421627957 0.458521737107425 no 1520 0.442268026601717 493 4736863 YCR052W RSC6 SGTC_1979 st071809 45.3 µM 0.143829244342998 0.459066814084945 no 1521 0.442817654661464 491 4976333 SGTC_2701 st077767 14.721 µM 0.143659361053714 0.45913333351066 no 1522 0.442884731708938 450 5721188 SGTC_2194 5927483 104.545 µM 0.143486840124219 0.459200886900585 no 1523 0.44295285188276 427 760979 SGTC_2206 7254556 146.969 µM 0.142740043151329 0.459493321024535 no 1524 0.44324774532362 484 4398905 SGTC_1774 st048371 48.465 µM 0.141738052387627 0.459885719486423 no 1525 0.443643458448338 492 4242727 SGTC_363 0455-0021 3.06 µM 0.139546134618204 0.460744251498878 no 1526 0.444509301193715 483 4597466 SGTC_2279 7948423 32.93 µM 0.138910700689576 0.460993173136861 no 1527 0.444760357512563 446 1247112 SGTC_1156 4092-0367 4.88 µM 0.134958147102264 0.462541865704509 no 1528 0.44632248264354 488 1357585 SGTC_795 0685-0265 78 µM 0.134411626746585 0.462756048957113 no 1529 0.446538544124114 480 302754 SGTC_3094 9117742 49.47 µM 0.134393837201622 0.462763020924252 no 1530 0.446545577313904 494 17149698 SGTC_3174 9107204 49.47 µM 0.132678525640372 0.463435328507455 no 1531 0.447223813376309 456 3938802 SGTC_2280 7785178 200 µM 0.131633025616297 0.46384515824086 no 1532 0.447637281072867 466 2954328 SGTC_1107 amlodipine 47 µM 0.131370354286661 0.463948129873091 no 1533 0.447741169620819 497 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2340 7987427 183.45 µM 0.131325987869206 0.4639655225025 no 1534 0.447758717237083 477 2239331 SGTC_944 3370-0224 231 µM 0.130612930182802 0.464245066512271 no 1535 0.448040756776023 466 4580514 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.130263239718597 0.464382164088299 no 1536 0.448179081333549 487 6708760 SGTC_2468 5987765 72.9 µM 0.128546363350358 0.465055333532381 no 1537 0.448858304945322 461 26772094 SGTC_2012 4023501 200 µM 0.128370436458751 0.465124318326854 no 1538 0.448927912924589 492 3477460 SGTC_1649 st011737 51.3 µM 0.128182323148975 0.465198082842839 no 1539 0.449002344372789 492 1761035 SGTC_1991 st073000 8.92 µM 0.127503770996092 0.465464172132648 no 1540 0.449270844360149 483 4301969 YIL048W NEO1 SGTC_1704 st028805 70.8 µM 0.126251883151929 0.46595513128051 no 1541 0.449766271538686 471 2876101 SGTC_402 epigallocatechin gallate 10 µM 0.125783319792144 0.466138903495187 no 1542 0.449951722886564 490 65064 An antioxidant. SGTC_605 1315-0399 119 µM 0.124494616509462 0.466644374621303 no 1543 0.450461831312286 471 24020461 SGTC_2370 9071495 200 µM 0.123756660877588 0.466933848976804 no 1544 0.450753973772502 495 21791103 SGTC_2753 fluvastatin 17.09 µM 0.123225411872598 0.467142250340881 no 1545 0.450964301576368 471 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_103 0844-0104 51.839 µM 0.12253659602772 0.467412476318772 no 1546 0.451237032459579 476 5375804 SGTC_2833 9001315 45.46 µM 0.122490595616289 0.467430523051747 no 1547 0.451255246759886 479 2989378 SGTC_1098 clofazimine 15.1 µM 0.122444358926855 0.467448662548009 no 1548 0.451273554720138 495 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2015 5119600 184 µM 0.122166067347823 0.467557842834852 no 1549 0.451383749727507 493 2828786 SGTC_3002 9075603 71.4286 µM 0.121732817857313 0.467727821584401 no 1550 0.451555310811562 505 20105405 SGTC_1371 2421-0008 32.7 µM 0.120816411824886 0.468087378694144 no 1551 0.451918225286226 488 2827552 SGTC_118 0083-0097 135.343 µM 0.120666663022029 0.468146135969711 no 1552 0.451977532529756 509 5207356 SGTC_108 0509-0257 621.132 µM 0.119725160516475 0.468515571276909 no 1553 0.452350434254026 462 536624 SGTC_679 0422-0091 41.4 µM 0.119644368798665 0.468547274332846 no 1554 0.452382435463655 502 627384 YHR062C RPP1 SGTC_2344 7990960 76.95 µM 0.119434784466027 0.468629517155298 no 1555 0.452465452248184 490 140813 SGTC_1492 4158-0558 28.5 µM 0.11925191048169 0.468701279684883 no 1556 0.452537890706718 498 3967268 SGTC_1868 st057644 42.7 µM 0.117347350486156 0.469448717973026 no 1557 0.453292401968233 468 688665 SGTC_2218 6965428 192.983 µM 0.117267219239492 0.469480167595314 no 1558 0.453324150511428 481 675684 SGTC_2356 9061756 188.97 µM 0.11723969312755 0.469490970988264 no 1559 0.453335056612452 482 20104043 SGTC_138 0850-0259 40.9225 µM 0.114971028104861 0.470381448537764 no 1560 0.454234042979336 497 6813004 SGTC_1128 3448-9350 235 µM 0.114745727404096 0.470469889856213 no 1561 0.454323334023991 455 619386 SGTC_1482 3346-2049 8.48 µM 0.113821673660062 0.470832640410738 no 1562 0.4546895785756 495 3826804 SGTC_2900 5328528 85.29 µM 0.112968430869558 0.471167614608521 no 1563 0.455027791738514 507 795359 SGTC_1376 2910-0861 41.3 µM 0.11248146039719 0.471358803282987 no 1564 0.455220834454335 479 1112859 SGTC_395 anisomycin 6.25 µM 0.11046122606424 0.472152034157683 no 1565 0.456021799380659 498 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_299 1273-0059 1.44 µM 0.110205826529109 0.472252322928745 no 1566 0.456123070760643 494 2848077 SGTC_1469 k284-2957 126 µM 0.110012117125406 0.472328388759247 no 1567 0.456199882584857 493 23884841 SGTC_2858 9025781 8.96 µM 0.108569396436308 0.472894948045151 no 1568 0.456772017668512 497 4894980 YPL153C RAD53 SGTC_2663 amphotericin b 100 µM 0.10833882733011 0.472985498104217 no 1569 0.456863462050916 493 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_293 4049-0273 38.5 µM 0.108245915190227 0.473021987341396 no 1570 0.456900311923531 478 1380311 SGTC_78 0336-0123 156.75 µM 0.107965063568608 0.473132287127999 no 1571 0.457011702703397 491 6765896 SGTC_40 0327-0103 19.753 µM 0.107895244213188 0.473159707834514 no 1572 0.457039394833947 480 409036 SGTC_178 4092-0806 87.505 µM 0.107307599216797 0.473390503319502 no 1573 0.457272478026059 493 2169044 SGTC_1614 st002383 48.6 µM 0.106747704273242 0.473610408380769 no 1574 0.457494568127105 500 1947235 SGTC_342 k048-0088 23.3 µM 0.106485127836681 0.473713541015381 no 1575 0.457598727291949 496 6820570 SGTC_3259 9138485 49.47 µM 0.106338525987355 0.473771122862878 no 1576 0.457656882772998 447 17646153 SGTC_1202 1988-0068 29.6 µM 0.106016470423744 0.473897620831966 no 1577 0.45778464216186 500 2850480 SGTC_614 0462-0418 107 µM 0.105101603440464 0.474256979398394 no 1578 0.458147593495589 496 5188303 SGTC_438 sphingosine 6.67 µM 0.104193154045334 0.474613837872578 no 1579 0.458508033341754 473 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1407 3909-7909 12.3 µM 0.102136879394817 0.475421661598302 no 1580 0.459324014271834 509 4411780 SGTC_648 0375-0473 33.3 µM 0.0988244001357866 0.476723206298162 no 1581 0.460638847407577 494 1713139 SGTC_432 NS 1619 61.3 µM 0.0964143306661425 0.477670331566755 no 1582 0.461595755460589 479 4552 A K+/calcium channel activator. SGTC_36 0335-0881 14.2 µM 0.0963165970174066 0.477708742289013 no 1583 0.461634564928051 504 23828853 SGTC_340 k038-0059 454 µM 0.0957955476954854 0.477913525613488 no 1584 0.461841476761287 493 23733424 SGTC_1619 st003326 88.7 µM 0.0956009880286967 0.477989993146107 no 1585 0.46191874023149 506 2849032 SGTC_1074 carmofur 3.8 µM 0.0953384157430783 0.47809319287395 no 1586 0.462023015128235 504 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_545 4218-0007 221 µM 0.094784666531726 0.478310839721154 no 1587 0.462242933183962 496 2840508 SGTC_759 3486-0358 89.3 µM 0.092460295907062 0.47922448543462 no 1588 0.463166167662169 506 875103 SGTC_1474 0330-0125 5.35 µM 0.0923123366992269 0.479282647847781 no 1589 0.463224943477312 514 X1474 SGTC_674 0498-0004 451 µM 0.091517550793359 0.479595083818168 no 1590 0.463540680619797 486 4231473 SGTC_550 4123-0385 25.7 µM 0.0914049646201815 0.479639343258713 no 1591 0.463585408534543 493 5731123 SGTC_675 1309-0189 238 µM 0.0906923017251556 0.479919508338468 no 1592 0.463868543878245 491 4246530 SGTC_839 0122-0028 230 µM 0.0898922031836061 0.48023405830694 no 1593 0.464186438513415 515 759448 SGTC_2657 nystatin 74.44 µM 0.0888211377955113 0.48065515515248 no 1594 0.464612029276277 505 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2546 rhodinyl acetate 100 µM 0.0871764570862577 0.481301814735148 no 1595 0.465265626311477 498 6708682 SGTC_3054 9094397 49.47 µM 0.0870286910928836 0.481359916163915 no 1596 0.465324353214359 491 2598354 SGTC_341 1486-1430 230 µM 0.0867393558302313 0.481473683621775 no 1597 0.465439346430977 502 2054753 YPL210C SRP72 SGTC_3185 9108267 49.47 µM 0.0860651530128954 0.481738787947837 no 1598 0.465707312336652 498 4910486 SGTC_789 1309-1135 70.6 µM 0.08505066191208 0.482137712733538 no 1599 0.466110557101167 490 3092424 SGTC_2566 crystal violet carbinol 226 nM 0.0848642527756252 0.482211015702916 no 1600 0.466184655690661 513 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0835236623547718 0.482738203020559 no 1601 0.466717581643723 496 4330530 SGTC_354 2783-3500 4.88 µM 0.0824262156707148 0.483169796548732 no 1602 0.467153894942742 507 6740761 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0823975599734307 0.483181066258722 no 1603 0.467165288156441 509 2374 Ca(2+)-ATPase inhibitor. SGTC_612 0302-0167 22.4 µM 0.0820860763355107 0.48330356738014 no 1604 0.467289132615346 500 235821 SGTC_2709 st078560 56 µM 0.0812910634314098 0.483616239307786 no 1605 0.467605240409294 512 17250903 SGTC_2306 7482397 179.52 µM 0.0810969385681507 0.483692588531172 no 1606 0.467682430169577 513 891448 SGTC_928 2764-0428 58.7 µM 0.080401384727667 0.483966154440569 no 1607 0.467959012809317 512 662578 SGTC_265 mycophenolic acid 32.932 µM 0.0800768249454772 0.484093808532385 no 1608 0.468088077280131 512 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2164 5685496 200 µM 0.0795510572470219 0.484300604083665 no 1609 0.468297161220527 486 759046 SGTC_372 0155-0182 15.9 µM 0.0778907912445575 0.484953649262106 no 1610 0.468957462339379 504 771486 SGTC_1426 4048-4480 71.7 µM 0.0772560776700573 0.485203316786195 no 1611 0.469209915685699 503 14224343 SGTC_568 1193-0097 7.48 µM 0.0770985127850204 0.485265296565982 no 1612 0.469272588053166 489 3646150 SGTC_2238 6671620 73.2395 µM 0.0769182843385463 0.485336191728811 no 1613 0.46934427592 477 729941 SGTC_406 estrone 100 µM 0.0769168606408381 0.485336751760349 no 1614 0.46934484221554 518 5870 A steroid. SGTC_1511 0906-3109 28.5 µM 0.076572807350324 0.485472090811385 no 1615 0.469481696006514 504 2882180 SGTC_286 k060-0067 22.9 µM 0.0761283398063494 0.485646931944579 no 1616 0.469658496826642 498 5985051 SGTC_3182 9108849 49.47 µM 0.0749654187135156 0.486104405631058 no 1617 0.470121113155671 508 17133045 SGTC_2927 9011802 47.9 µM 0.0744781614648273 0.486296089945372 no 1618 0.47031495876209 498 43912568 SGTC_1895 st058434 18.3 µM 0.0741402926469913 0.486429007536503 no 1619 0.470449377285111 513 5393175 SGTC_3338 9144300 39.5675 µM 0.0735617792619969 0.486656598191679 no 1620 0.470679542217426 504 4901274 SGTC_603 3794-0023 45.9 µM 0.0733710080426601 0.486731649696565 no 1621 0.470755443813693 504 3802260 SGTC_1250 0485-0349 40.2 µM 0.0724575815116971 0.48709100824863 no 1622 0.471118880873578 506 6842794 YDL195W SEC31 SGTC_1613 st002381 52.1 µM 0.0717199861211036 0.487381199306581 no 1623 0.471412375247715 525 551167 SGTC_471 1-acyl-paf 4 µM 0.070430492187571 0.487888538946391 no 1624 0.471925511122819 511 16759367 SGTC_329 k048-0121 21.3 µM 0.0700037705118297 0.488056433058471 no 1625 0.472095329283909 496 6832902 SGTC_1813 st051246 8.6015 µM 0.0699450796317706 0.488079525215953 no 1626 0.472118686304487 513 5291959 SGTC_1164 k060-0068 93.7 µM 0.0699435536387446 0.488080125624442 no 1627 0.472119293600298 521 5963676 SGTC_1147 3809-1045 12.3 µM 0.0693079762455015 0.48833019860295 no 1628 0.472372238440722 504 325925 SGTC_114 0364-0001 490.298 µM 0.0675192387588875 0.489034015895792 no 1629 0.473084173329226 477 4003655 SGTC_2724 maprotiline 69.64 µM 0.0672463701841353 0.489141384970505 no 1630 0.473192785287086 523 4011 A tricyclic antidepressant. SGTC_1263 0774-1208 64.8 µM 0.0663935531714166 0.489476958783698 no 1631 0.473532251351836 520 906585 SGTC_73 0327-0325 16.231 µM 0.0649482705709306 0.490045677963735 no 1632 0.47410759366937 517 53298 SGTC_1318 1280-3875 124 µM 0.0644488592660002 0.490242201240554 no 1633 0.474306413396216 508 373245 SGTC_3242 9133940 49.47 µM 0.0642793322941179 0.490308912317854 no 1634 0.474373904928172 504 17248444 SGTC_206 4546-0025 72.014 µM 0.0641306116045561 0.490367436074642 no 1635 0.474433113735705 527 6620745 YIL048W NEO1 SGTC_1655 st012546 55.1 µM 0.0634517531072957 0.490634579392554 no 1636 0.474703388610872 522 720985 YLR208W SEC13 SGTC_1230 0170-0365 3.77 µM 0.0631158327259483 0.49076677180884 no 1637 0.474837133371816 523 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1714 st033236 13.627 µM 0.0628278938385141 0.490880083208597 no 1638 0.474951776835517 520 2916566 SGTC_799 1310-0557 151 µM 0.0627396515925131 0.490914808962549 no 1639 0.474986911083942 523 5354492 SGTC_1408 3909-7976 48.8 µM 0.0624992405204839 0.491009417688798 no 1640 0.475082633368053 523 24152374 SGTC_2481 5478948 45.16 µM 0.06151314552049 0.491397479892288 no 1641 0.475475272810413 516 77792 SGTC_1155 4088-0394 48.2 µM 0.0613289954578688 0.491469950171184 no 1642 0.475548599611262 520 2326248 SGTC_1154 4088-0362 150 µM 0.0604319977387226 0.491822957969483 no 1643 0.475905787354603 524 6618304 SGTC_2925 9010536 32.5 µM 0.0595702557976383 0.492162097113675 no 1644 0.476248954358983 508 2994177 SGTC_125 0133-0007 11.75 µM 0.0592156779853912 0.492301643119116 no 1645 0.476390161164243 529 26541 SGTC_1510 1123-0200 71.5 µM 0.0585869025566996 0.492549103377449 no 1646 0.476640571504473 521 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_832 4083-0019 164 µM 0.0584294916234189 0.492611054326813 no 1647 0.476703261987893 526 1990758 SGTC_1468 k284-1086 134 µM 0.0583951921713224 0.492624553308785 no 1648 0.476716922165364 504 15996457 SGTC_1756 st041558 35.5 µM 0.0582306305689007 0.492689318720144 no 1649 0.476782461222086 512 3955792 SGTC_1933 st074711 15.9 µM 0.0574644052221861 0.492990879425349 no 1650 0.477087629876033 533 17250958 SGTC_2963 9082507 9 µM 0.0569752751983504 0.493183386771843 no 1651 0.477282445336391 512 16459611 SGTC_1214 0358-0031 63.7 µM 0.0569070071753788 0.493210255206748 no 1652 0.477309636220984 505 4301366 SGTC_2 0422-0095 29 µM 0.0552333053446161 0.493868988008774 no 1653 0.477976297798148 493 6790840 SGTC_1810 st050138 53 µM 0.0550554636657823 0.493938983657063 no 1654 0.47804713857107 533 3444541 SGTC_158 k038-0087 26.446 µM 0.0550248919907263 0.493951016199616 no 1655 0.4780593164449 489 X158 SGTC_932 2857-0803 154 µM 0.0546324800097729 0.494105464023416 no 1656 0.478215631042484 518 674898 SGTC_3106 9121286 49.47 µM 0.0532473224204248 0.494650649432009 no 1657 0.478767425614951 520 15943471 SGTC_200 k038-0079 37.545 µM 0.0530694976443758 0.494720640389013 no 1658 0.478838267273018 524 3436683 SGTC_1417 3966-0327 90.4 µM 0.0519126738653867 0.495175964408148 no 1659 0.479299137804681 516 651118 SGTC_3044 9093193 49.47 µM 0.0505779168786986 0.495701330429016 no 1660 0.479830930038129 526 25236277 SGTC_2768 sulfasalazine 50.2 µM 0.0492724567649917 0.496215172294504 no 1661 0.480351084582947 529 5384001 An antioxidant and salicylic acid derivative. SGTC_2815 7968870 71.43 µM 0.0491613423870717 0.496258908302111 no 1662 0.480395359150537 521 2977326 YHR190W ERG9 SGTC_2153 5569715 200 µM 0.0484941726633917 0.496521515569252 no 1663 0.480661204260332 528 2054701 SGTC_2618 avocadyne 43.43 µM 0.0481106289019761 0.496672484409039 no 1664 0.480814037688665 513 3015189 SGTC_207 4185-0010 4.486 µM 0.0469964314087238 0.497111052641922 no 1665 0.481258035855572 521 3761753 SGTC_1113 artemisinin 1.17947 µM 0.0464257678357168 0.497335677504185 no 1666 0.481485449444359 527 2240 An anti-malaria and mitochondrial poison. SGTC_1909 st060837 51.5 µM 0.0438747390792769 0.498339823956012 no 1667 0.482502125599882 526 678937 SGTC_1161 k007-0610 110 µM 0.0433197453677778 0.498558284480663 no 1668 0.482723325734288 533 5843850 SGTC_2420 aureobasidin a 50 nM 0.0433098951662099 0.49856216179032 no 1669 0.482727251711529 482 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_732 3970-1727 52.7 µM 0.0416912562340685 0.499199304068436 no 1670 0.483372412208337 533 1275699 SGTC_2290 7904846 200 µM 0.0415723250547557 0.499246118860439 no 1671 0.483419817784575 514 2962154 SGTC_1854 st056233 32.9 µM 0.0412376642438374 0.499377851201123 no 1672 0.483553213736752 527 5393174 SGTC_2327 6189656 200 µM 0.041061981066256 0.499447005296369 no 1673 0.483623241869453 527 5349088 SGTC_1995 st072814 61.1 µM 0.0408754596140992 0.499520425675213 no 1674 0.48369759074171 508 5769371 SGTC_1165 k072-0275 30.3 µM 0.0401678182565301 0.499798974440412 no 1675 0.483979667112478 531 6153523 YGL055W OLE1 SGTC_35 0133-0054 64.071 µM 0.0399584779501649 0.499881377059813 no 1676 0.484063114815536 523 99677 SGTC_2651 TUB2.036 5 µM 0.0396639002020957 0.499997331698958 no 1677 0.484180541240423 521 15992207 YFL037W TUB2 SGTC_765 1319-0117 244 µM 0.0396571214987517 0.5 no 1678 0.484183243425748 519 3487746 YGL099W LSG1 SGTC_173 1273-0061 2.693 µM 0.0391388127588819 0.499795978136237 no 1679 0.484389858278064 526 2847414 YPL266W DIM1 SGTC_1804 st050076 49.1 µM 0.0391147999159057 0.499786525961994 no 1680 0.484399430686361 530 3895976 SGTC_1568 digitonin 820 nM 0.0383592845867761 0.499489132587495 no 1681 0.484700611632887 535 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3148 9097893 49.47 µM 0.0369060773088943 0.498917107787399 no 1682 0.485279947029197 532 17174100 SGTC_1 0258-0098 57.368 µM 0.0367049338577332 0.498837932002939 no 1683 0.485360137323058 510 6790032 YDR047W HEM12 SGTC_1040 k898-0338 155 µM 0.0364765452056249 0.498748031787982 no 1684 0.485451190237578 533 20969351 SGTC_900 1112-0045 141 µM 0.0357884533769075 0.498477179840047 no 1685 0.485725520020329 531 56211 YIL048W NEO1 SGTC_529 4076-0302 30.3 µM 0.0354241811516972 0.498333792507739 no 1686 0.485870751519592 505 5816522 SGTC_637 1181-0519 7.26 µM 0.0347612795346641 0.49807285719078 no 1687 0.486135048206775 535 6252091 YGR060W ERG25 SGTC_1915 st067105 30.6 µM 0.0345690156968416 0.497997177293182 no 1688 0.486211704308953 536 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_715 0868-0130 184 µM 0.0335219031693371 0.497585008718596 no 1689 0.486629199721255 529 2876258 SGTC_1562 morin hydrate 59.1 µM 0.0326663519861052 0.497248245171656 no 1690 0.486970328394047 525 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2006 4011487 200 µM 0.0324882207982573 0.497178129101897 no 1691 0.487041354756827 531 45595294 SGTC_1385 3091-4834 14.1 µM 0.0316226908429059 0.496837440133422 no 1692 0.487386473880681 528 4072814 SGTC_2565 isoliquiritigenin 100 µM 0.0312695779734742 0.496698448874569 no 1693 0.487527275899409 534 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2229 7354935 190 µM 0.0312055591658806 0.496673250020469 no 1694 0.487552803250843 533 318112 SGTC_2064 5220758 200 µM 0.0302165668350791 0.496283968143986 no 1695 0.487947168070257 536 788518 SGTC_2477 5967686 25.23 µM 0.0289216576357813 0.495774278311654 no 1696 0.488463536275001 526 776118 SGTC_571 k831-0106 44.2 µM 0.0280540977755287 0.49543280146574 no 1697 0.488809502158809 538 4783639 SGTC_2011 4012611 177 µM 0.0275103413461233 0.495218777312882 no 1698 0.489026345884316 532 2049887 SGTC_2282 7944268 200 µM 0.0262893181740372 0.494738184057594 no 1699 0.489513287415249 529 2970414 SGTC_2225 6654152 15.4 µM 0.026162134578114 0.494688125174046 no 1700 0.489564008883175 535 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_895 0964-0006 13.7 µM 0.0251622500732043 0.49429457816773 no 1701 0.489962773746552 535 6738897 SGTC_3029 9088683 49.47 µM 0.0244783108621048 0.494025388023108 no 1702 0.490235541977895 538 25236615 SGTC_1247 0448-0043 5.84 µM 0.0242046559688555 0.493917681544831 no 1703 0.490344682146719 532 3089013 YGL099W LSG1 SGTC_2544 sphondin 68.51 µM 0.0241053354671843 0.493878590588223 no 1704 0.49038429373648 536 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2759 disulfiram 3.38 µM 0.0236670605139024 0.49370609330255 no 1705 0.490559090272151 533 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2810 7959871 45.46 µM 0.022570640347991 0.493274566903506 no 1706 0.490996381733861 534 2974535 SGTC_357 1325-0123 420 µM 0.0222436955943903 0.493145890278028 no 1707 0.49112678107921 538 1098503 SGTC_2659 sanguinarine 24.21 µM 0.0207486803678188 0.492557501949632 no 1708 0.491723068023545 538 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1367 1812-0510 76.9 µM 0.0202427681253535 0.492358395300529 no 1709 0.491924855417744 536 1142582 YDR527W RBA50 SGTC_785 1270-0111 65.3 µM 0.0200023184779942 0.492263764683985 no 1710 0.492020761529191 542 6741994 SGTC_1596 piperlongumine 63 µM 0.0199081201814655 0.492226692413319 no 1711 0.492058333730831 523 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0198844593596589 0.492217380574041 no 1712 0.492067771164891 525 2724 A muscle relaxant with antifungal properties. SGTC_389 tpck 16.7 µM 0.0194064317699322 0.492029251249372 no 1713 0.492258439782607 527 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3173 9105693 49.47 µM 0.017873386143885 0.491425928286844 no 1714 0.49286993020151 533 17096658 SGTC_1797 st048695 56.8 µM 0.0175956355843545 0.49131662290689 no 1715 0.4929807192191 539 592262 YIL048W NEO1 SGTC_2572 astragaloside iv 100 µM 0.0172912653576452 0.49119684242734 no 1716 0.493102126898958 539 45006101 An anti-inflammatory agent. SGTC_1726 st035556 14.5795 µM 0.0164545896271363 0.490867584975072 no 1717 0.493435864702873 514 5919439 SGTC_137 0438-0332 85.389 µM 0.0158628251535539 0.490634711325901 no 1718 0.493671913749315 537 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_254 nsc-64875 3.808 µM 0.0154663895419179 0.490478706094264 no 1719 0.493830049272386 540 56993 SGTC_1357 1503-1303 39.5 µM 0.0144224539435284 0.490067903877723 no 1720 0.494246472797968 545 292895 SGTC_684 1140-0066 328 µM 0.0143751226591794 0.490049278648976 no 1721 0.494265353291177 538 6813534 SGTC_2374 9071832 200 µM 0.0135444860393447 0.489722420242755 no 1722 0.494596697061884 541 17381698 SGTC_2386 9075165 157.42 µM 0.0103298495178546 0.488457516583538 no 1723 0.495879059565309 543 16452277 SGTC_2803 7707263 71.43 µM 0.00997061229518263 0.488316169951057 no 1724 0.49602236709888 545 2199229 SGTC_292 k038-0015 474 µM 0.0093905455088754 0.488087938114165 no 1725 0.496253769419123 541 46368540 SGTC_122 0236-0016 402.397 µM 0.00903444858176484 0.487947830906637 no 1726 0.496395825510232 545 6808838 SGTC_1480 1070-0044 41.2 µM 0.00878656356571034 0.487850300817412 no 1727 0.496494713397777 541 3124987 SGTC_86 0417-1630 471.922 µM 0.00829303702951758 0.487656125509067 no 1728 0.496691594818333 544 3634867 SGTC_4 0960-0234 25.671 µM 0.00723856619161297 0.487241259605677 no 1729 0.497112255114821 526 6821112 SGTC_2198 6589944 200 µM 0.00578393433540685 0.486668979040815 no 1730 0.497692556912042 547 5290268 SGTC_258 haloperidol 50.781 µM 0.00446479415749951 0.486150027250229 no 1731 0.498218810755105 546 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1234 0326-0494 15.5 µM 0.0042768885031808 0.486076106762541 no 1732 0.498293773549172 544 1547813 SGTC_377 3970-0964 33.1 µM 0.00321937364427844 0.485660098399302 no 1733 0.498715657955453 546 16481235 SGTC_749 1000-0129 128 µM 0.0029725435358639 0.485563001861518 no 1734 0.498814128449607 546 708470 SGTC_83 0170-0301 39.027 µM 0.0025601673447172 0.485400785717618 no 1735 0.49897864211703 546 3089716 SGTC_1337 1486-1011 40.3 µM 0.00253697552141793 0.485391662837249 no 1736 0.498987894285856 545 X1337 SGTC_2406 ethylparaben 405.7 µM 0.00242891902219089 0.485349157159139 no 1737 0.499031002459168 540 8434 A possible steroid mimic. SGTC_135 0933-0004 26.348 µM 0.00115607972185304 0.484848478995436 no 1738 0.499538791022174 548 21230617 YGL099W LSG1 SGTC_211 3455-0679 143.504 µM 0.000783336335588487 0.484701862872342 no 1739 0.499687494047919 539 748649 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.000237502944585701 0.484487166688588 no 1740 0.499905250034576 546 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_315 k915-0449 187 µM -0.000648145277091614 0.484138818532051 no 1741 0.49974142746323 549 20970215 YNL149C PGA2 SGTC_3278 9139605 49.47 µM -0.00115011045379046 0.483941388113933 no 1742 0.499541172414004 551 7958859 SGTC_3027 9089541 49.47 µM -0.00215324635769149 0.483546851590522 no 1743 0.4991409796516 549 9943819 SGTC_2438 5259590 200 µM -0.00250608675988663 0.483408082154314 no 1744 0.499000217079645 550 1201127 SGTC_2583 asiatic acid 100 µM -0.00298479402088743 0.483219813459877 no 1745 0.498809241234856 549 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_881 0833-0569 170 µM -0.00432766157052161 0.482691703031201 no 1746 0.498273518213366 551 5418700 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0046449050959243 0.482566944855618 no 1747 0.498146957632062 550 688664 SGTC_1709 st033179 39.1045 µM -0.00490887969649277 0.482463136347905 no 1748 0.498041648204768 552 573381 SGTC_326 k292-0812 17.5 µM -0.00524066527401231 0.482332662733205 no 1749 0.497909286614861 551 3579357 SGTC_3170 9103054 49.47 µM -0.00563996053030078 0.482175643663851 no 1750 0.497749993213143 555 16432970 SGTC_1322 1348-1070 12 µM -0.00704458319786224 0.481623311264822 no 1751 0.497189641159136 552 6758089 SGTC_1956 st077085 54 µM -0.0070995240811327 0.481601707859586 no 1752 0.497167723465981 553 24208685 SGTC_2982 9019404 25.97 µM -0.00720473650260164 0.481560337241685 no 1753 0.497125750856179 555 22333232 SGTC_2985 9022375 71.43 µM -0.00741010242876091 0.481479585797057 no 1754 0.497043823892837 567 4939335 SGTC_876 0720-0963 56.8 µM -0.00769833694369513 0.481366251075293 no 1755 0.496928838239503 550 765861 SGTC_24 0417-1663 219 µM -0.00865376141499931 0.480990585975402 no 1756 0.496547691776276 557 4329390 SGTC_1017 4239-0030 168 µM -0.00941880409469814 0.480689789595526 no 1757 0.496242496373004 554 1149593 SGTC_203 k066-0004 30.888 µM -0.0112656500441266 0.479963699829351 no 1758 0.495505750945899 549 6795412 SGTC_2345 9052315 157.45 µM -0.012064041610252 0.479649831638725 no 1759 0.495187260471332 554 6469265 SGTC_408 cantharidin 100 µM -0.0140261937611102 0.478878513341227 no 1760 0.494404541745777 552 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2998 9066762 71.4286 µM -0.0152105239130664 0.478412993492656 no 1761 0.493932112882688 558 4945196 SGTC_1127 asiatic acid 681.4 nM -0.0155455316702017 0.47828131866826 no 1762 0.493798479926674 563 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2086 5274770 176.623 µM -0.0156267569128764 0.478249393436984 no 1763 0.493766079678845 558 689278 SGTC_816 0325-0417 81.3 µM -0.016150877182988 0.478043393590328 no 1764 0.493557012337137 558 68101 SGTC_2254 7938975 95.19 µM -0.0164172387201635 0.477938705291716 no 1765 0.493450763546358 567 2969277 SGTC_730 1436-0052 41.2 µM -0.0170280155010441 0.477698656939716 no 1766 0.493207132935939 557 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1814 st052110 31.539 µM -0.0178179380524793 0.477388212475553 no 1767 0.492892047267471 562 674163 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0180578200751202 0.477293940059671 no 1768 0.492796363581749 565 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1363 1636-0063 10.4 µM -0.0182394729653978 0.477222552242043 no 1769 0.49272390649726 555 6072185 SGTC_3083 9117465 49.47 µM -0.0186356384241492 0.477066865611526 no 1770 0.492565886208027 556 16420915 SGTC_414 piperonyl butoxide 100 µM -0.0190353343218076 0.476909795122713 no 1771 0.492406458899173 562 5794 A potent inhibitor of cytochrome P450. SGTC_1068 loratadine 26.9 µM -0.0206684353115509 0.476268064819683 no 1772 0.491755074305682 563 3957 A H1 histamine antagonist. SGTC_1386 3228-0095 33.8 µM -0.0209740819840757 0.476147967135242 no 1773 0.491633165353764 557 870181 SGTC_102 gallobenzophenone 83.616 µM -0.0217115889449776 0.475858187618945 no 1774 0.491339009655671 555 70837 SGTC_163 TUB2.036 7.546 µM -0.0226832941652981 0.475476406986834 no 1775 0.49095145086643 557 15992207 YJR013W GPI14 SGTC_537 1334-0398 209 µM -0.022953189820045 0.475370369616799 no 1776 0.490843806106245 570 5846986 SGTC_1294 1000-1494 117 µM -0.0237902155676486 0.475041527695318 no 1777 0.490509972344027 566 712797 YDL207W GLE1 SGTC_3091 9116372 49.47 µM -0.0238856528588895 0.475004034366057 no 1778 0.490471909189613 561 17169793 SGTC_1307 1187-1599 12.2 µM -0.0243758774050147 0.474811449094225 no 1779 0.490276394824922 561 1538471 SGTC_433 pimozide 108 µM -0.0245823888971736 0.474730322578333 no 1780 0.490194033339806 567 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_770 0389-1121 67.2 µM -0.0250887736861758 0.474531397491914 no 1781 0.489992077332932 563 6753108 SGTC_1807 st050092 58.9 µM -0.0260987572765559 0.474134660759203 no 1782 0.489589284137933 567 5008496 SGTC_1520 flindersine 88 µM -0.0263858195297185 0.474021903056297 no 1783 0.489474802294621 566 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_291 SEC14.278 35.5 µM -0.0264307940557873 0.474004237305653 no 1784 0.489456866309989 560 1068044 SGTC_1369 1866-0067 208 µM -0.0265467301942176 0.47395869845321 no 1785 0.489410630706124 564 3531355 SGTC_2785 7756463 72.73 µM -0.0266290365754883 0.473926369325628 no 1786 0.489377806814608 559 2201551 SGTC_2467 5474540 200 µM -0.0283023842391042 0.473269132543922 no 1787 0.488710489507575 561 5413519 SGTC_2475 5812728 15.03 µM -0.0300923096594109 0.472566188379488 no 1788 0.487996716978953 563 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2149 5554786 194.827 µM -0.0307940655650228 0.472290616168544 no 1789 0.487716886585151 567 745063 YPR165W RHO1 SGTC_2767 sibutramine 71.45 µM -0.0310269711192186 0.472199159516234 no 1790 0.487624015090557 570 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3348 9149464 3.537 µM -0.0313447172062436 0.472074390303626 no 1791 0.487497314369355 560 1951442 SGTC_996 3970-0799 1.8 µM -0.0322275781757922 0.471727732108139 no 1792 0.487145281696963 564 6615648 YGL040C HEM2 SGTC_2539 epi(13)torulosol 80 µM -0.0326280538639687 0.471570491088259 no 1793 0.48698559899405 573 6708597 SGTC_136 0097-0015 404.482 µM -0.0328838905995324 0.471470042791292 no 1794 0.48688358964397 565 4861337 SGTC_3240 9133527 49.47 µM -0.0331610830080408 0.471361211738571 no 1795 0.48677306615128 589 17617455 SGTC_627 1391-0720 175 µM -0.0352131060404672 0.470555615216926 no 1796 0.485954905801972 569 997839 SGTC_721 1187-1332 279 µM -0.0356469926674252 0.470385292509221 no 1797 0.48578191869137 568 25730 SGTC_927 2425-1185 123 µM -0.038192670106401 0.469386093980949 no 1798 0.484767032520758 581 730375 SGTC_1108 betulinic acid 729.144 nM -0.0382161170894078 0.469376891740967 no 1799 0.484757685351829 562 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1650 st011916 45.8 µM -0.0387576194451191 0.469164372813533 no 1800 0.484541817105289 562 242528 SGTC_917 harmaline 728.087 nM -0.0396189049453189 0.468826369377418 no 1801 0.484198477652225 570 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2933 9026794 32.47 µM -0.0408012500921804 0.468362405726994 no 1802 0.483727171380449 563 17586027 SGTC_594 1487-1584 10.8 µM -0.0426906352018817 0.467621082219622 no 1803 0.482974072395868 577 5013332 SGTC_123 0083-0120 66.675 µM -0.0437441483671486 0.467207771954095 no 1804 0.482554173785176 568 16001701 SGTC_3339 9145883 14.936 µM -0.0440156762961146 0.467101252865253 no 1805 0.482445954050167 568 2030670 SGTC_1300 1094-0077 113 µM -0.0441835728311972 0.46703538904765 no 1806 0.482379038123588 561 5532636 SGTC_2389 9091542 195.52 µM -0.0453741121695196 0.466568380594773 no 1807 0.481904557612635 564 3626624 YOL127W RPL25 SGTC_3237 9133362 49.47 µM -0.046267686840465 0.466217891571624 no 1808 0.481548446940767 575 43845137 SGTC_2515 chrysin 20.77 µM -0.0463604392609569 0.466181512554422 no 1809 0.481511483742792 581 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2619 obliquin 87.91 µM -0.0489216992901889 0.465177057149531 no 1810 0.480490848016052 575 6708593 A bioactive alkalod. YER133W GLC7 SGTC_495 decylubiquinone 155 µM -0.0493307526501251 0.465016658103712 no 1811 0.480327856136849 594 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_975 1335-0046 28.5 µM -0.0496495998774798 0.46489163485722 no 1812 0.48020081017812 581 16486740 SGTC_1084 voriconazole 435 nM -0.0517314459663027 0.464075407542406 no 1813 0.479371340260014 576 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1622 st003707 19.4 µM -0.0519123577181227 0.464004484742759 no 1814 0.479299263759359 569 10140899 SGTC_1465 k213-0056 144 µM -0.0551252585911267 0.462745124446462 no 1815 0.478019336645122 569 24048857 YMR208W ERG12 SGTC_110 0850-0284 111.64 µM -0.0563397985580735 0.462269157943156 no 1816 0.477535557251648 571 3906265 SGTC_937 3122-0005 46.7 µM -0.0571311098501097 0.461959079699693 no 1817 0.477220377404996 569 759535 SGTC_1893 st059353 36.1 µM -0.0592419902816793 0.461132037035082 no 1818 0.4763796824728 597 3112488 SGTC_3335 9143315 29.6265 µM -0.0594512421154759 0.461050061293385 no 1819 0.476296349947933 578 4899691 SGTC_700 3453-2283 142 µM -0.0607407790558227 0.460544913624099 no 1820 0.475782827314877 570 565664 SGTC_680 0417-1641 114 µM -0.060839778091763 0.460506135555303 no 1821 0.475743405322233 571 2835990 SGTC_3231 9132313 49.47 µM -0.0609820526560226 0.460450407055916 no 1822 0.475686751178106 598 4905967 SGTC_2585 alliin 100 µM -0.062671834703945 0.459788584446525 no 1823 0.475013912970048 579 87310 A garlic compound which reacts with lipids. SGTC_2068 5226020 147 µM -0.0634713818415861 0.45947547131219 no 1824 0.474695573631617 587 1810509 SGTC_1763 st044482 94.5 µM -0.0638568124880266 0.459324540587893 no 1825 0.474542120348937 573 88505 SGTC_1730 st033808 45.1 µM -0.0652780692910566 0.458768041698717 no 1826 0.473976301632751 571 1045166 SGTC_87 0100-0052 35.5 µM -0.0659538267719006 0.458503474378735 no 1827 0.473707293132901 572 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_585 0kpi-0023 191 µM -0.0662517241433404 0.458386849744526 no 1828 0.473588708641904 572 64601 SGTC_2336 9001819 198.65 µM -0.0668816528214528 0.458140249099178 no 1829 0.473337959628574 566 2989602 SGTC_3299 9121982 43.1275 µM -0.0671105941425866 0.458050628530947 no 1830 0.473246830002483 599 17594604 YPL160W CDC60 SGTC_3234 9132280 49.47 µM -0.0690663751034145 0.457285112753288 no 1831 0.472468392936122 578 17612295 SGTC_845 0330-0138 4.51 µM -0.0696354038919399 0.457062417794574 no 1832 0.472241928547434 575 9039800 SGTC_2495 cafestol 54.53 µM -0.0697910087868122 0.457001522648039 no 1833 0.472180001838643 622 16667697 An anti-infammatory. SGTC_1892 st058411 7.36 µM -0.0699698056881751 0.456931552679996 no 1834 0.472108846143734 585 3934738 SGTC_3295 9122362 53.5725 µM -0.0700578716193346 0.456897089651745 no 1835 0.472073798925336 588 4730473 SGTC_1927 st060202 13.8 µM -0.0711906806587739 0.456453814074686 no 1836 0.47162299917784 580 688887 SGTC_1989 st071868 50.2 µM -0.0718821223989983 0.456183275000849 no 1837 0.47134785874977 578 16414057 SGTC_1038 k292-0204 154 µM -0.0721040711165126 0.456096437855449 no 1838 0.471259543189308 568 4454212 SGTC_2217 6934799 96.0675 µM -0.0721277753732625 0.456087163719871 no 1839 0.471250111117699 590 675606 SGTC_1796 st049173 110.4 µM -0.072250391193374 0.456039191463442 no 1840 0.471201321775673 574 94134 SGTC_333 3486-0131 40.1 µM -0.0733937954714772 0.455591876516461 no 1841 0.470746377389014 575 6744690 SGTC_2266 7929956 200 µM -0.0741564097334085 0.455293562939935 no 1842 0.470442965149044 578 2967153 SGTC_1450 4112-4260 37.6 µM -0.0743814065139759 0.455205555239206 no 1843 0.470353451633741 582 1633175 SGTC_2541 muurolladie-3-one 83.07 µM -0.0748956070903648 0.455004433463648 no 1844 0.470148885888126 605 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_756 0508-1999 28.3 µM -0.075016342859716 0.454957211164225 no 1845 0.470100854404704 585 6753853 SGTC_2968 9090663 33.37 µM -0.0754162719009574 0.454800795052257 no 1846 0.469941756486856 616 25236811 SGTC_2456 5770359 74.46 µM -0.0755165801223239 0.45476156463607 no 1847 0.469901853086787 580 3118787 SGTC_2991 9074669 71.4286 µM -0.0767288201956065 0.454287494102806 no 1848 0.469419638459166 589 17333109 SGTC_1759 st043059 70 µM -0.0769030711957213 0.454219355128455 no 1849 0.469350327162086 602 669426 SGTC_1350 1495-0454 146 µM -0.0771932742028542 0.4541058773637 no 1850 0.469234896045884 577 1069057 SGTC_1167 k781-0610 148 µM -0.0782155155701918 0.453706181339944 no 1851 0.46882831009356 596 4525169 SGTC_3249 9135183 49.47 µM -0.0793832373420054 0.453249659918804 no 1852 0.468363900612463 588 4902779 SGTC_2445 5742597 35.57 µM -0.0794569760378496 0.453220833805538 no 1853 0.468334575759025 586 1774255 SGTC_1346 1488-2224 62.4 µM -0.0816405613982141 0.452367333591849 no 1854 0.467466272801759 597 3722427 SGTC_1298 1079-1278 263 µM -0.083297281216866 0.451719916449873 no 1855 0.466807581029085 604 2840950 SGTC_2837 9008476 45.46 µM -0.0835087324766926 0.451637294196748 no 1856 0.466723517067536 607 2992805 SGTC_2433 5607874 27.82 µM -0.0836954019259689 0.451564356904248 no 1857 0.466649306525627 580 2252428 SGTC_2029 5175081 200 µM -0.083793133645917 0.451526170873411 no 1858 0.466610453689024 586 1380876 SGTC_2730 imipramine 71.33 µM -0.0841384262114475 0.451391260720305 no 1859 0.466473186623798 594 3696 A tricyclic antidepressant. SGTC_2972 9093619 59.92 µM -0.0842140062685763 0.451361731388706 no 1860 0.466443141177781 584 25236256 SGTC_2085 5307070 144.047 µM -0.0845386762669742 0.451234885010486 no 1861 0.466314076835694 608 2840351 SGTC_1664 st014217 9.02 µM -0.0860091239081276 0.45066045357043 no 1862 0.465729582137882 593 3982782 SGTC_1341 1486-1360 280 µM -0.0877450939043742 0.449982428723089 no 1863 0.465039639032687 587 3976547 SGTC_1514 1189-1591 158 µM -0.0878558421497905 0.449939178263976 no 1864 0.464995626845756 613 767698 YMR146C TIF34 SGTC_824 1304-0008 100 µM -0.088041648913711 0.449866616573591 no 1865 0.464921786800398 590 768245 SGTC_977 1348-1378 135 µM -0.0886866874708109 0.449614727638119 no 1866 0.464665456351028 578 X977 SGTC_2774 tamoxifen 10.92 µM -0.0887805068343211 0.449578092664791 no 1867 0.464628174900073 579 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2557 derrustone 83.84 µM -0.0895223896763707 0.449288414343275 no 1868 0.464333380315719 621 629853 An antioxidant. SGTC_3104 9120930 49.47 µM -0.089866869005518 0.449153916847564 no 1869 0.464196504647188 570 17014836 SGTC_2160 5660466 132.927 µM -0.089960827158974 0.449117233115991 no 1870 0.464159171980588 620 2859134 SGTC_1438 4092-1045 4 µM -0.0915065239329726 0.448513815147809 no 1871 0.463545061319188 583 1351342 SGTC_533 1222-0222 6.71 µM -0.0919023431077088 0.448359312086732 no 1872 0.46338781490591 610 3982874 SGTC_3103 9120822 49.47 µM -0.0919534248288659 0.448339373546319 no 1873 0.463367522173255 576 17141819 SGTC_3179 9107801 49.47 µM -0.0930258907192453 0.4479207920863 no 1874 0.462941496292514 586 4818259 SGTC_1653 st012112 65 µM -0.0947053463198965 0.447265420332274 no 1875 0.462274435659543 586 720429 SGTC_2365 9042475 200 µM -0.0950121064934446 0.447145729209437 no 1876 0.462152605416833 586 6464479 SGTC_1001 4048-4355 44.4 µM -0.0968518814573039 0.446427990566123 no 1877 0.461422011057161 611 21824233 SGTC_53 0973-0023 39.979 µM -0.0975043506297815 0.44617348932329 no 1878 0.461162939696136 614 674768 SGTC_1016 4226-1401 38 µM -0.0978321751471718 0.446045626897871 no 1879 0.461032778926638 580 2901613 SGTC_2556 citropten 84.59 µM -0.0979906676177152 0.445983811593275 no 1880 0.460969851932561 584 2775 A potential DNA crosslinker. SGTC_2272 7805186 180 µM -0.0993676225021966 0.44544682644043 no 1881 0.460423194502219 585 2956062 YPR165W RHO1 SGTC_1770 st043884 66.3 µM -0.0997879625433913 0.445282922034805 no 1882 0.460256332423255 586 670149 SGTC_2287 7945887 168.79 µM -0.100109719470658 0.445157464745591 no 1883 0.460128609538605 607 1245853 SGTC_1297 1068-0111 14.1 µM -0.100264457017873 0.44509713248078 no 1884 0.460067187225333 582 767057 SGTC_1253 0550-0034 176 µM -0.101735361489537 0.444523689617466 no 1885 0.459483366671872 593 5969915 SGTC_1181 1222-0449 220 µM -0.102635573977478 0.444172792389309 no 1886 0.459126103983973 609 658318 SGTC_1936 st074407 74.3 µM -0.103414737476092 0.443869114620303 no 1887 0.458816908022025 582 809813 SGTC_233 rapamycin 362 pM -0.103568495574086 0.443809191527117 no 1888 0.458755895032554 588 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2368 9071271 200 µM -0.104369046167621 0.44349721920116 no 1889 0.458438243039972 617 27209959 SGTC_802 4112-3352 742 µM -0.104407334068527 0.443482299389235 no 1890 0.458423051374357 584 704594 SGTC_3263 9137018 49.47 µM -0.104618742084278 0.443399920556556 no 1891 0.45833917114272 591 43844957 SGTC_1239 0337-0584 35.4 µM -0.104813194625193 0.443324150880984 no 1892 0.458262019962538 608 914301 YML130C ERO1 SGTC_1364 1653-0028 37.6 µM -0.106156195286697 0.442800898814671 no 1893 0.457729212795318 581 5718652 SGTC_2030 5175110 200 µM -0.107614931359311 0.44223266763438 no 1894 0.457150576133566 631 2831986 SGTC_780 0109-0199 192 µM -0.108116283275055 0.442037400063458 no 1895 0.456951725840997 594 610414 SGTC_668 1682-0499 62.6 µM -0.108243075716093 0.441988018913248 no 1896 0.456901438092863 593 682214 SGTC_958 1222-0007 33 µM -0.108481088137726 0.441895323967954 no 1897 0.456807040728007 619 7312461 SGTC_2102 5377816 72.7585 µM -0.110268166449855 0.441199440731815 no 1898 0.456098351385078 591 1379702 SGTC_601 0986-0029 62.9 µM -0.110451705750511 0.441127981288893 no 1899 0.456025574337517 603 24747981 SGTC_1374 2889-5571 141 µM -0.11058311929606 0.441076817736239 no 1900 0.455973467113081 588 2853281 SGTC_985 1493-0307 8.71 µM -0.111122597095859 0.440866791857521 no 1901 0.455759564910988 613 3278274 SGTC_1273 0849-0096 14.1 µM -0.111743749265624 0.44062498966337 no 1902 0.455513294819463 613 5286025 SGTC_1695 st026914 34.495 µM -0.111924689029412 0.440554557569068 no 1903 0.455441560291138 601 3289191 SGTC_1242 0402-0103 60.1 µM -0.113536022160631 0.439927417849389 no 1904 0.4548028030738 600 432868 SGTC_1801 st050089 28.441 µM -0.116120970157182 0.438921657300181 no 1905 0.453778334728354 605 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2299 7976368 114.88 µM -0.117444052880951 0.43840701979715 no 1906 0.453254088221344 605 2979718 SGTC_1889 st059080 5.18 µM -0.117975643987683 0.438200276877331 no 1907 0.453043478186284 623 176925 Isolated from Daphnopsis sellowiana. SGTC_2421 5690543 90.72 µM -0.118335291247303 0.438060414790048 no 1908 0.452900997732919 608 3397993 SGTC_1507 4075-3230 155 µM -0.119511746015051 0.437602961147373 no 1909 0.452434967378951 590 659771 SGTC_1753 st043925 64 µM -0.119803553803114 0.437489507249708 no 1910 0.452319383347302 600 670181 SGTC_22 0964-0034 14.468 µM -0.123651453754754 0.435993940740274 no 1911 0.450795625428388 600 138402 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.123988986089376 0.435862795094924 no 1912 0.450661997798441 590 551469 SGTC_1850 st056238 17 µM -0.126031055385346 0.435069515360197 no 1913 0.449853670962542 604 5393177 SGTC_1232 0279-0259 161 µM -0.126548284306878 0.434868629525324 no 1914 0.449648965438111 604 1560000 SGTC_564 3555-0129 330 µM -0.127163829887691 0.434629580530592 no 1915 0.449405366245977 607 563260 SGTC_811 0416-0114 265 µM -0.127853353789041 0.434361830211497 no 1916 0.449132513136951 591 6612453 SGTC_2592 piperlongumine 83.33 µM -0.129644630426823 0.433666397216437 no 1917 0.448423795611926 614 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_827 3253-0474 693 µM -0.130250370749163 0.433431275078413 no 1918 0.448184171940119 615 5402065 SGTC_1785 bathophenanthroline 24 µM -0.13051975195785 0.43332672053199 no 1919 0.44807761400374 602 72812 An iron chelator. SGTC_2362 9071156 126 µM -0.130887779029866 0.433183886250036 no 1920 0.447932041215431 611 653133 SGTC_371 0195-0006 7.36 µM -0.131304401267622 0.433022202324647 no 1921 0.447767255114679 598 3928593 SGTC_2502 avocadyne acetate 18.59 µM -0.132832166557059 0.432429399026457 no 1922 0.447163057266826 601 3952079 SGTC_600 1495-0418 41.6 µM -0.133076286059664 0.432334689863823 no 1923 0.447066524652707 608 5377768 SGTC_1224 0823-0416 294 µM -0.1334935463178 0.432172817621173 no 1924 0.446901533942164 627 3598164 SGTC_175 3793-3120 23.7 µM -0.134514644842634 0.431776740005584 no 1925 0.44649781571093 640 5322297 SGTC_1624 st003710 6.25 µM -0.13489607046491 0.431628805006015 no 1926 0.4463470232343 654 24207033 SGTC_1304 1165-0502 251 µM -0.135185356943898 0.431516612341792 no 1927 0.446232662139569 599 767425 SGTC_1522 st012842 45.6 µM -0.136544722943703 0.430989489704036 no 1928 0.445695335901296 591 3491067 YOR116C RPO31 SGTC_3209 9113616 49.47 µM -0.13667267346293 0.430939880524627 no 1929 0.445644765112222 622 16649353 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.136945153810013 0.430834237641815 no 1930 0.445537073724553 599 2333 A French combination drug. SGTC_766 1391-0721 126 µM -0.137149660000681 0.430754952151994 no 1931 0.445456250147638 654 1020919 YIL115C NUP159 SGTC_33 0986-0033 35.816 µM -0.141018520636926 0.429255553746657 no 1932 0.44392765559903 592 2848082 SGTC_3062 9077494 49.47 µM -0.14230245718397 0.428758181396397 no 1933 0.44342055286349 599 16459633 SGTC_2055 5235184 200 µM -0.142866081638052 0.428539879791601 no 1934 0.443197973331464 627 2836034 SGTC_1288 0973-0013 65.5 µM -0.142878795536655 0.428534955728295 no 1935 0.443192952723809 612 4315430 SGTC_1268 0828-0275 2.46 µM -0.143108285388683 0.428446076756806 no 1936 0.443102330751907 627 745337 SGTC_1597 7-benzyloxygramine 47.5 µM -0.143329873092599 0.428360261646779 no 1937 0.443014832039487 617 260807 SGTC_2441 5730946 39.09 µM -0.145197736285177 0.427637022205838 no 1938 0.442277376588826 604 1774275 SGTC_2483 5729050 27.16 µM -0.145399477689599 0.427558922132662 no 1939 0.442197738512548 630 2865180 SGTC_150 3970-0969 77.2 µM -0.145753934480886 0.427421708286664 no 1940 0.44205782119976 609 6615640 SGTC_2223 6903751 107.57 µM -0.146097841698393 0.427288586679171 no 1941 0.441922075105883 616 5598863 SGTC_2473 5854593 8.94 µM -0.147757510812935 0.42664626894612 no 1942 0.441267071319491 624 2872951 SGTC_2114 5491910 81.25 µM -0.148066213079481 0.426526817773572 no 1943 0.441145256773036 619 2849228 SGTC_217 ketoconazole 989 nM -0.14839509795218 0.426399564432525 no 1944 0.441015484254884 601 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_979 1426-2828 121 µM -0.149096954216272 0.426128025271396 no 1945 0.440738564606065 620 747872 SGTC_769 0302-0231 76 µM -0.149479342005107 0.425980099083265 no 1946 0.440587704458443 615 571869 YER009W NTF2 SGTC_998 3996-0085 177 µM -0.150019083095726 0.425771318718089 no 1947 0.440374779753698 599 715391 SGTC_2665 lovastatin 100 µM -0.151554243945087 0.425177608240853 no 1948 0.4397692622295 612 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_936 3005-4620 401 µM -0.152563484134466 0.424787385472718 no 1949 0.439371261628533 624 777207 SGTC_2938 9059746 27.26 µM -0.155276054798859 0.423738936139974 no 1950 0.438301846072776 645 6471769 SGTC_817 1391-0715 46 µM -0.156316075674509 0.423337095145591 no 1951 0.437891942771833 613 1353946 SGTC_68 0986-0284 82.829 µM -0.157864557541204 0.422738943949526 no 1952 0.437281763394786 595 423278 YIL048W NEO1 SGTC_2316 5844804 197.44 µM -0.1600954102501 0.421877518384466 no 1953 0.436402958316573 646 776813 SGTC_2277 7947813 106.88 µM -0.160370669726481 0.421771254998019 no 1954 0.436294546363249 654 1246798 SGTC_97 0535-0701 19.132 µM -0.160387289125117 0.421764839293699 no 1955 0.436288000905315 605 2832013 YGL099W LSG1 SGTC_776 4476-4378 112 µM -0.160794871939619 0.421607503712658 no 1956 0.43612748214053 625 2892008 SGTC_3127 9126946 49.47 µM -0.161528619004197 0.421324293395649 no 1957 0.435838536301773 650 27243249 SGTC_294 k038-0071 157 µM -0.162329496331274 0.421015218724671 no 1958 0.435523194001446 618 24152826 SGTC_2488 5268135 45.7 µM -0.162550613791442 0.420929893614919 no 1959 0.435436137083556 638 1270356 YLR208W SEC13 SGTC_3300 9124615 50.48 µM -0.163042416837682 0.420740129301325 no 1960 0.435242518835263 634 24824903 SGTC_1037 k284-1091 78.7 µM -0.163375555950797 0.420611596606225 no 1961 0.43511137390684 616 3334711 SGTC_3080 9117754 49.47 µM -0.163442746244728 0.420585674078099 no 1962 0.435084924360863 611 9550191 SGTC_172 1112-0046 2.638 µM -0.164163294262206 0.420307702826288 no 1963 0.434801297986469 646 2802135 YIL048W NEO1 SGTC_1312 1218-2183 165 µM -0.164414310537337 0.420210875708434 no 1964 0.434702499346701 613 6744073 SGTC_2177 5811945 192 µM -0.164489792307492 0.420181760284431 no 1965 0.434672790929884 602 5343475 SGTC_734 2023-0417 80 µM -0.164926627819806 0.420013269226801 no 1966 0.434500866712342 640 3935732 SGTC_2073 5212005 126 µM -0.167957426881253 0.418844670355154 no 1967 0.433308385818366 622 691789 SGTC_2595 hexamethylquercetagetin 100 µM -0.170965824828076 0.417685416497615 no 1968 0.432125318873228 660 386331 SGTC_1285 0929-0069 65.5 µM -0.170977507774587 0.41768091598677 no 1969 0.432120725677464 617 1206237 SGTC_708 3448-5400 146 µM -0.171039955565426 0.417656859998558 no 1970 0.43209617424173 618 3462195 SGTC_616 4092-0450 108 µM -0.171111378915144 0.417629346844846 no 1971 0.432068094374036 631 787165 SGTC_134 0269-0018 6.916 µM -0.172201917301619 0.417209308188023 no 1972 0.431639395304956 609 4378915 SGTC_1497 4476-2978 41.3 µM -0.173153904876435 0.416842711848748 no 1973 0.431265227421585 608 1528379 SGTC_1627 st003713 25.6 µM -0.173465267096964 0.416722826536311 no 1974 0.43114286341203 624 16195070 YER133W GLC7 SGTC_67 0335-0847 266 µM -0.173855717566788 0.416572500436619 no 1975 0.430989427403014 688 4552207 YOR254C SEC63 SGTC_2255 7941087 197.44 µM -0.174054041206615 0.416496149150595 no 1976 0.430911495800119 637 935561 SGTC_1454 4239-0054 42.6 µM -0.17416156991749 0.416454753711362 no 1977 0.430869243339477 642 1340767 SGTC_1725 st036284 20.55 µM -0.175414608112609 0.415972438724911 no 1978 0.430376931467054 639 707914 SGTC_419 nsc-638432 893 µM -0.176782200067233 0.41544617454368 no 1979 0.429839735561804 641 368090 SGTC_2980 9014342 25.29 µM -0.177274394067352 0.415256810025434 no 1980 0.429646431403919 634 2996599 SGTC_1002 4049-0206 172 µM -0.180838515028087 0.413886156028652 no 1981 0.428247165428085 616 4662749 SGTC_3315 9136395 68.55 µM -0.181678052401544 0.413563447084476 no 1982 0.42791769547844 653 16876844 SGTC_1049 3226-0134 66 µM -0.18303547398641 0.413041792723785 no 1983 0.42738509227728 608 5702385 SGTC_428 3448-4153 16.5 µM -0.183630922970461 0.412813011269313 no 1984 0.427151501297159 620 3834874 SGTC_2885 9057732 51.95 µM -0.185042013997112 0.412270964877093 no 1985 0.426598041075984 646 6471414 SGTC_1055 3448-0672 86 µM -0.185255940234231 0.412188803364876 no 1986 0.426514147196362 660 748378 SGTC_745 0469-0705 296 µM -0.185349652935365 0.412152812838118 no 1987 0.42647739762234 647 3486736 SGTC_1800 st050079 29.0735 µM -0.185356360910448 0.412150236656888 no 1988 0.426474767104491 636 3645560 SGTC_2761 levamisole 97.89 µM -0.189493616670669 0.410562059199956 no 1989 0.424852978813676 643 26879 An alkaline phosphatase inhibitor. SGTC_2312 7706453 155.7 µM -0.189710831252627 0.410478716823781 no 1990 0.424767866417996 649 976098 SGTC_2313 7726885 200 µM -0.189785856258056 0.410449931655701 no 1991 0.424738469768261 628 726423 SGTC_807 1315-0151 48 µM -0.193821059307398 0.408902442447225 no 1992 0.42315799837522 670 4011080 SGTC_1353 1498-1206 8.11 µM -0.196278551739348 0.407960694522781 no 1993 0.422196074049712 636 6756808 SGTC_1137 ixabepilone 100 µM -0.19652912554238 0.407864700654871 no 1994 0.422098019129661 606 154225 A novel microtubule stabilizer. SGTC_1026 k007-1105 30.6 µM -0.199017636210067 0.406911662816166 no 1995 0.421124474421583 600 7066794 SGTC_1591 genipin 88.4 µM -0.199544670789263 0.406709892160662 no 1996 0.420918351823483 628 442424 A DNA cross-linking agent. SGTC_2351 9026858 72.31 µM -0.200117369097358 0.406490667614466 no 1997 0.420694394771659 641 1409300 SGTC_1631 benzylvanillin 81.9 µM -0.200152499241211 0.406477221016499 no 1998 0.420680657756416 646 75506 SGTC_2581 avocatin a 64 µM -0.200421983982606 0.406374075293554 no 1999 0.420575283775541 678 6710728 A skin care supplement. SGTC_3289 9119912 71.43 µM -0.201059296235197 0.406130168854235 no 2000 0.420326104460959 691 17014829 SGTC_151 3013-0144 2.285 µM -0.201451315710477 0.405980156758646 no 2001 0.420172846712882 662 906558 YHR107C CDC12 SGTC_554 4483-2211 187 µM -0.201551577841763 0.40594179217538 no 2002 0.420133651754764 631 747107 SGTC_1567 st069303 68.4 µM -0.202731368561094 0.405490421687866 no 2003 0.419672501847398 656 5581319 SGTC_204 PMA1.184 62.41 µM -0.202808339557842 0.405460978082208 no 2004 0.419642419686196 633 2252213 YGL008C PMA1 SGTC_3346 9158254 43.5805 µM -0.202980433596885 0.405395149130176 no 2005 0.419575162796275 627 17639500 SGTC_692 k241-0027 77.8 µM -0.202980783726906 0.405395015202103 no 2006 0.41957502596269 632 3600480 SGTC_2687 chenodiol 100 µM -0.203749234427464 0.405101102195673 no 2007 0.419274732804808 625 5702181 A cholesterol synthesis inhibitor. SGTC_2750 bromebric acid 70.15 µM -0.20444464568725 0.404835171056202 no 2008 0.419003022327355 660 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2996 9066192 71.4286 µM -0.205814646507279 0.404311399845655 no 2009 0.418467849935151 656 6472854 SGTC_1583 clindamycin 39.6 µM -0.205946099027787 0.404261152638502 no 2010 0.41841650769399 659 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3137 9097352 49.47 µM -0.205983014265881 0.404247042218429 no 2011 0.418402089726232 639 44120435 SGTC_1980 st071811 45.7 µM -0.206500412541827 0.404049285866006 no 2012 0.418200021262057 679 4974850 SGTC_676 falcarinol 140 µM -0.206671100863015 0.40398405194516 no 2013 0.418133364143999 656 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2870 9038528 12.99 µM -0.207228888460338 0.403770894466691 no 2014 0.417915553616665 655 6463316 SGTC_3236 9132701 49.47 µM -0.208574676381971 0.403256721912589 no 2015 0.417390140545797 663 24282524 SGTC_1554 st069299 38.7 µM -0.208986206117876 0.403099525952145 no 2016 0.417229503394409 634 24207999 SGTC_971 1315-0384 26.7 µM -0.210151114886183 0.402654639553816 no 2017 0.416774866096561 671 6769120 SGTC_2626 ethyl orsellinate 100 µM -0.210907692725637 0.402365764918114 no 2018 0.416479650610416 631 75653 A natural product. SGTC_43 0570-0105 72.5 µM -0.21173584765563 0.402049622016781 no 2019 0.41615655986006 641 1114046 YDL195W SEC31 SGTC_2965 9082772 38.63 µM -0.211768624881525 0.402037110835109 no 2020 0.416143773539365 638 16459634 SGTC_3341 9147222 25.867 µM -0.212103314667884 0.401909364321575 no 2021 0.416013216903145 671 1939759 SGTC_1558 st069300 45.6 µM -0.212718523940135 0.401674574700752 no 2022 0.415773258702925 632 24208000 SGTC_2075 5212009 200 µM -0.213819555725322 0.401254463506002 no 2023 0.415343887172426 636 780898 SGTC_877 0771-0151 33.1 µM -0.214846228971468 0.400862827476199 no 2024 0.414943604440841 661 6166523 SGTC_1690 st023502 41.2 µM -0.216106872355048 0.400382077200289 no 2025 0.414452221461102 628 24207482 SGTC_3210 9128157 49.47 µM -0.216715688258781 0.400149957347517 no 2026 0.414214960541953 676 17590849 SGTC_2823 7987624 58.44 µM -0.218300619308332 0.399545845119829 no 2027 0.413597445978907 680 2239440 SGTC_3015 9080845 49.47 µM -0.219182591746333 0.399209776580127 no 2028 0.413253907784611 671 5296973 SGTC_2874 9043904 71.43 µM -0.219377263358252 0.399135608573255 no 2029 0.413178089937154 647 4463428 SGTC_1106 tegaserod maleate 11.7 µM -0.221106705836078 0.398476867815817 no 2030 0.412504674486488 650 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1896 st058441 89 µM -0.222132417022972 0.398086313214728 no 2031 0.412105401523019 638 688759 SGTC_1503 4585-0012 61.3 µM -0.222716351651949 0.397864017104243 no 2032 0.411878137102018 658 2922052 SGTC_21 0849-0113 22.993 µM -0.223242034404047 0.397663925061125 no 2033 0.411673569295349 637 1560156 SGTC_2411 st077133 39.94 µM -0.223249591390546 0.397661048821135 no 2034 0.411670628692474 698 1403142 YNL221C POP1 SGTC_2413 inermin 26.06 µM -0.223439589371314 0.397588736137879 no 2035 0.411596697597759 681 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3043 9092303 49.47 µM -0.224372062450113 0.397233890635607 no 2036 0.411233903734149 652 25236084 SGTC_446 go6976 132 µM -0.225533289259517 0.396792113575939 no 2037 0.410782215642086 665 3501 A protein kinase C inhibitor. SGTC_2952 9073731 13.78 µM -0.226342815705639 0.396484215686971 no 2038 0.41046740010165 659 16457353 SGTC_458 nppb 133 µM -0.226680506505626 0.396355796349516 no 2039 0.410336093063973 648 4549 A chloride channel blocker. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.227310176033081 0.396116371410164 no 2040 0.410091280436822 660 1273210 SGTC_2567 aureobasidin a 60 nM -0.228045398311418 0.395836860781581 no 2041 0.409805473730287 638 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_673 1082-0474 110 µM -0.228994860479338 0.395475981485696 no 2042 0.409436455372954 664 3098046 SGTC_3291 9121177 71.43 µM -0.229425153380844 0.395312461751735 no 2043 0.409269243954763 661 17015612 SGTC_3033 9090887 49.47 µM -0.229758191264768 0.395185913481873 no 2044 0.409139837075495 639 19325384 SGTC_65 0798-0905 34.986 µM -0.229785308503194 0.395175609916567 no 2045 0.409129300700367 748 3602145 SGTC_2520 obtusaquinone 4.71 µM -0.231608315191023 0.394483102042683 no 2046 0.40842112426195 629 5967872 SGTC_3246 9135460 32.98 µM -0.23315995821352 0.393893939935825 no 2047 0.407818598850348 641 41446951 SGTC_2666 tannic acid 100 µM -0.233400218943461 0.393802734105431 no 2048 0.407725321588031 648 16134267 A thiamine antagonist. SGTC_1629 st005085 44.9 µM -0.233491807997565 0.393767967344535 no 2049 0.407689765026408 664 24207091 SGTC_1837 st055472 66.5 µM -0.233760837456009 0.393665849963938 no 2050 0.407585327222201 654 676091 SGTC_216 k038-0035 28.382 µM -0.233762497523672 0.393665219863216 no 2051 0.407584682800808 638 4444231 YPR107C YTH1 SGTC_2944 9067346 25.62 µM -0.233768162981798 0.39366306946546 no 2052 0.407582483529432 674 6473075 SGTC_873 0591-4978 488 µM -0.233983831193291 0.393581212224192 no 2053 0.407498765560018 642 3305145 SGTC_1632 st005650 90 µM -0.234660712751448 0.393324331221385 no 2054 0.40723604149689 648 2759605 SGTC_2896 9052656 71.43 µM -0.234887622233152 0.393238227967118 no 2055 0.40714797843336 668 6469436 SGTC_2781 5567276 71.43 µM -0.235469714394425 0.393017370697385 no 2056 0.406922091238169 682 2853274 SGTC_485 niflumic acid 177 µM -0.235701107114676 0.392929585286707 no 2057 0.406832305371471 660 4488 A COX2 inhibitor. SGTC_337 1315-0038 354 µM -0.235820056961551 0.392884460397399 no 2058 0.406786151913381 673 1626437 SGTC_491 tetrandrine 80.3 µM -0.23584052316085 0.392876696472191 no 2059 0.40677821100071 664 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1977 st070720 65.3 µM -0.23637197688177 0.392675102551018 no 2060 0.406572019676423 658 682188 SGTC_1335 1486-0900 202 µM -0.236582224757531 0.392595358125705 no 2061 0.406490455679465 629 X1335 SGTC_2122 5258151 111.688 µM -0.236769310718315 0.392524402519978 no 2062 0.406417880574916 662 2173356 SGTC_2688 kanamycin b 96.69 µM -0.23691310872476 0.392469867052096 no 2063 0.406362100084815 656 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_582 0987-0078 156 µM -0.236938616807469 0.39246019331908 no 2064 0.406352205477378 641 1625765 SGTC_1041 0206-0046 107 µM -0.239877047347012 0.391346263571028 no 2065 0.405212787496431 685 50494 SGTC_2054 5233173 129 µM -0.240905353028711 0.390956653009675 no 2066 0.404814236596745 644 6889 SGTC_2773 thioridazine 9.09 µM -0.241944480894963 0.390563053224676 no 2067 0.404411591516655 639 5452 An antipsychotic. SGTC_2372 9071633 200 µM -0.242595220289537 0.390316623889544 no 2068 0.404159492141296 623 21321366 SGTC_3197 9113331 49.47 µM -0.244337092650292 0.389657209090747 no 2069 0.40348487903799 667 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3330 9141424 71.43 µM -0.244595761723171 0.389559312635606 no 2070 0.403384723026918 647 27261020 SGTC_1912 st060209 90.8 µM -0.245454390074509 0.389234404566342 no 2071 0.403052309761665 689 688787 SGTC_3056 9094900 49.47 µM -0.248384648460949 0.388126168500368 no 2072 0.401918405119484 660 25236784 SGTC_1970 st070122 35.8 µM -0.249512005625408 0.387700039278787 no 2073 0.40148237768596 701 102928 SGTC_2361 9034121 116 µM -0.249583686005427 0.387672949411619 no 2074 0.401454658038033 665 6496917 SGTC_1133 3473-0247 50 µM -0.249748235660782 0.387610763914951 no 2075 0.401391026622669 669 711311 SGTC_287 k060-0039 29.6 µM -0.251977541293441 0.386768564483593 no 2076 0.4005292116327 658 5861974 SGTC_2807 7945238 51.95 µM -0.25449300330837 0.385818899391568 no 2077 0.399557354376516 691 17148797 SGTC_1051 3253-3903 78 µM -0.256020856586755 0.385242420769468 no 2078 0.398967366334549 632 5509239 SGTC_861 0443-0273 110 µM -0.256280771054484 0.385144376905454 no 2079 0.398867022016624 659 6149169 SGTC_7 0192-1582 4.227 µM -0.257669615592162 0.384620607265235 no 2080 0.398330948837851 665 252616 SGTC_298 1391-0729 10 µM -0.258040776695888 0.384480668305563 no 2081 0.398187718652976 652 3237558 SGTC_2754 granisetron 64.02 µM -0.258350455917322 0.384363921392876 no 2082 0.398068224676135 692 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1994 st072947 40.9 µM -0.261037349654208 0.38335142250404 no 2083 0.397031852309583 698 5286565 YDL195W SEC31 SGTC_64 000l-0018 272.079 µM -0.26119997363878 0.383290166590538 no 2084 0.396969149222584 667 6811119 SGTC_2429 5902844 64.44 µM -0.261820545636234 0.383056441272112 no 2085 0.396729899164487 675 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_808 0711-0032 135 µM -0.263217027897959 0.382530641555248 no 2086 0.396191653534228 682 4252555 SGTC_2451 5856223 45.7 µM -0.264775054423639 0.381944273143676 no 2087 0.395591377462115 642 2179896 SGTC_310 1273-0058 1.06 µM -0.265314501857807 0.381741313351712 no 2088 0.395383596920583 662 2734232 SGTC_704 1310-0270 142 µM -0.266112721971435 0.381441053491161 no 2089 0.39507619872186 694 5718033 SGTC_1926 methyl fluorone black 53.6 µM -0.267391928293282 0.380960013864505 no 2090 0.394583706776675 645 72721 Reacts with homocysteine. SGTC_1787 fluconazole 80 µM -0.268186303384025 0.380661385300968 no 2091 0.394277958636022 669 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_226 1,3-diallylurea 8.28947 mM -0.268249186400928 0.380637748791034 no 2092 0.394253758283188 666 74537 YKL182W FAS1 SGTC_1496 4469-0713 57.4 µM -0.269055971348851 0.380334533488478 no 2093 0.393943305604259 696 746691 SGTC_628 1636-0253 16 µM -0.269364460163215 0.380218613053518 no 2094 0.393824616206554 691 4456143 SGTC_2128 5255449 168.493 µM -0.270378314718571 0.379837714093188 no 2095 0.393434610690974 651 736008 SGTC_2908 7930301 100 µM -0.270581424387274 0.379761421033316 no 2096 0.393356492116467 684 2223178 SGTC_2246 7293507 91.5585 µM -0.271405488520092 0.379451930024752 no 2097 0.393039590593717 689 887656 SGTC_916 4466-0038 42 nM -0.271531750271343 0.37940451713938 no 2098 0.392991041719635 676 5722064 YGL116W CDC20 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.272831160636333 0.37891667759764 no 2099 0.392491502604065 708 5282309 SGTC_493 zm226600 134 µM -0.274601461908016 0.378252361209159 no 2100 0.391811221529617 708 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1019 4262-0212 3.4 µM -0.274663883042054 0.378228943851031 no 2101 0.391787240722216 666 4677213 SGTC_2373 9071805 200 µM -0.275956901516323 0.377743967242741 no 2102 0.391290584459279 714 10149009 SGTC_2094 5332512 191.667 µM -0.275962516246794 0.377741861727239 no 2103 0.391288428192957 696 755774 SGTC_2940 9060638 45.86 µM -0.276515950459052 0.377534342562634 no 2104 0.391075905178598 666 4027022 SGTC_1729 st035615 45.989 µM -0.278027707982555 0.376967664796796 no 2105 0.390495544528346 645 17385451 SGTC_644 1498-1197 63.3 µM -0.278112249443132 0.376935982494674 no 2106 0.390463096422119 673 6741615 SGTC_358 0075-0058 9.45 µM -0.280481672634008 0.376048368004913 no 2107 0.389553992257613 754 1069125 SGTC_373 0844-0104 25.9 µM -0.280814244756896 0.375923834817763 no 2108 0.389426438669949 670 5375804 SGTC_1390 3413-2614 145 µM -0.281321807933877 0.375733800323483 no 2109 0.389231792571676 699 3421432 SGTC_2617 dihydrotanshinone i 20.83 µM -0.28178178845379 0.375561607073959 no 2110 0.389055418015868 642 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1572 epiandrosterone 68.9 µM -0.281962015403614 0.375494146050904 no 2111 0.388986318172083 646 441302 A steroid. SGTC_1373 2887-0003 58.5 µM -0.28219587337171 0.375406615994846 no 2112 0.388896661183025 657 776948 SGTC_409 arachidonic acid 100 µM -0.282346911689272 0.37535008768669 no 2113 0.38883875892053 667 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2684 capsaicin 100 µM -0.282445284202939 0.375313271768182 no 2114 0.388801048022664 698 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1319 1306-0155 43.7 µM -0.283213693627572 0.375025733606326 no 2115 0.388506515956566 651 3122360 SGTC_656 4090-1979 187 µM -0.287887105326888 0.373278447771788 no 2116 0.386716578860812 678 22330961 SGTC_59 0330-0160 1.33 µM -0.290130049189794 0.372440782407577 no 2117 0.385858374029313 665 4293482 SGTC_583 1488-1091 88.9 µM -0.292127587419268 0.371695275471816 no 2118 0.385094537242649 700 4303273 SGTC_1952 st077036 64.1 µM -0.293602481186211 0.371145134619133 no 2119 0.384530839797076 689 2937007 SGTC_991 3996-0057 64.7 µM -0.294460493052106 0.370825214030044 no 2120 0.384203023916794 661 715343 SGTC_1031 k035-0009 16 µM -0.295001204850679 0.370623648633685 no 2121 0.38399647965421 717 5180959 SGTC_1105 epirubicin 18.1 µM -0.295989166381882 0.370255450173193 no 2122 0.383619177442733 672 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_748 act1.228 77.9 µM -0.297065770145866 0.369854351411994 no 2123 0.383208148408326 678 4421505 YNR035C ARC35 SGTC_2697 mebhydrolin 72.4 µM -0.299490087593836 0.368951668168599 no 2124 0.382283067056775 673 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1455 4262-0120 131 µM -0.299805700274238 0.368834204302924 no 2125 0.382162683518321 669 1529587 SGTC_720 r052-1644 49.9 µM -0.300189626400379 0.368691332242523 no 2126 0.382016258669949 696 1422863 YOR257W CDC31 SGTC_250 brefeldin a 552.239 µM -0.300579572864852 0.368546238384298 no 2127 0.381867555009975 665 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_248 streptozotocin 5.23457 mM -0.302996596848821 0.367647314922371 no 2128 0.380946227546498 693 5300 DNA alkylating agent. SGTC_3233 9132340 49.47 µM -0.304113364948053 0.367232218405152 no 2129 0.38052076251029 724 17682950 SGTC_2569 tetrandrine 100 µM -0.306111427814253 0.366489936825543 no 2130 0.37975990359107 663 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_815 1582-0027 36.9 µM -0.306591511335582 0.366311659771979 no 2131 0.379577157823595 669 3128206 SGTC_1563 conessine 56.1 µM -0.307422929267206 0.366002984382522 no 2132 0.379260738812849 687 441082 An anti-amoebic, histamine inhibitor. SGTC_596 1155-0152 116 µM -0.308107164205855 0.365749017744066 no 2133 0.379000394997719 677 280313 SGTC_2013 4024628 200 µM -0.308801211222068 0.36549146926728 no 2134 0.378736373861707 713 5230760 SGTC_1433 4060-0023 7.6 µM -0.309004619066311 0.365415999725984 no 2135 0.378659006577374 663 3840627 SGTC_252 miconazole 1.30953 nM -0.30920629555059 0.365341177707981 no 2136 0.378582302626027 694 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_327 1273-0057 3.96 µM -0.310032134003133 0.365034844956244 no 2137 0.378268260043964 683 3108138 SGTC_1735 st034310 56.75 µM -0.310062087271204 0.365023735844716 no 2138 0.378256871188373 702 871153 SGTC_3282 9108498 15.4605 µM -0.310210088020745 0.364968846774964 no 2139 0.378200599777424 698 16459645 SGTC_1136 pergolide 1.05886 µM -0.310918369092096 0.364706204745654 no 2140 0.37793133979609 682 47811 A dopamine receptor agonist. SGTC_235 0330-0087 5 mM -0.312041579349813 0.364289830496787 no 2141 0.377504462035205 682 46494818 YHR062C RPP1 SGTC_2834 9001755 58.44 µM -0.313252369215968 0.363841169794659 no 2142 0.377044467065506 713 2989575 SGTC_1060 3448-7350 82 µM -0.314242837176247 0.363474288566005 no 2143 0.376668304964837 707 570178 SGTC_1261 0712-0010 12.7 µM -0.314529715110667 0.363368048898764 no 2144 0.376559375680072 700 2840123 SGTC_1039 k821-0043 94 µM -0.315459306961013 0.363023864860107 no 2145 0.37620647160338 708 15992768 SGTC_899 1083-0020 478 µM -0.315692378515374 0.36293758678201 no 2146 0.376118006079523 719 767123 SGTC_2099 5377090 177.372 µM -0.318545939514901 0.361881825029247 no 2147 0.375035426634004 705 2243829 SGTC_1240 0356-0016 42.1 µM -0.319096729283393 0.361678164265235 no 2148 0.374826581889894 680 4305613 SGTC_650 1328-0195 38 µM -0.319279281625743 0.361610672107176 no 2149 0.374757371021125 710 2780821 SGTC_2185 6113692 200 µM -0.319541050197515 0.36151390011291 no 2150 0.374658134030242 692 874150 SGTC_2792 7535235 81.82 µM -0.321534106189044 0.36077738748129 no 2151 0.373902835131948 673 1281891 SGTC_2610 ononetin 44.17 µM -0.32208001051392 0.360575744263688 no 2152 0.373696040683863 697 259632 SGTC_3089 9117425 49.47 µM -0.3223491379048 0.360476349690533 no 2153 0.37359410570094 720 9401657 SGTC_747 3448-8087 38.7 µM -0.322580071831238 0.360391068305758 no 2154 0.37350664396528 718 5168703 SGTC_261 5-fluorouridine 15.376 µM -0.324394392393124 0.359721301400428 no 2155 0.372819732316286 672 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3187 9109394 49.47 µM -0.325474610396633 0.359322737050645 no 2156 0.372410947717875 676 17098090 SGTC_1941 st076221 61.8 µM -0.327296812426447 0.358650752357283 no 2157 0.37172170155548 662 2828568 SGTC_2123 5259487 200 µM -0.327397255703551 0.358613723969378 no 2158 0.371683720914299 688 2173474 SGTC_1660 st012960 28.1 µM -0.329711894835199 0.357760801695195 no 2159 0.370808832558445 733 24207266 SGTC_536 3852-0578 10.6 µM -0.33178199499196 0.35699859069626 no 2160 0.370026940415049 688 2869208 SGTC_1848 st056003 16.4 µM -0.334410182330349 0.356031714053828 no 2161 0.369035028437161 657 146492 SGTC_1955 wogonin 32.4 µM -0.33458519907073 0.355967360411094 no 2162 0.368969005729271 682 5281703 A flavanone. SGTC_852 0418-0143 439 µM -0.3347124236331 0.355920582524281 no 2163 0.368921014403312 708 5369229 SGTC_921 1561-0023 372 µM -0.334734806247026 0.355912353116224 no 2164 0.368912571501965 699 24050882 SGTC_1611 st001856 99.4 µM -0.335103247208022 0.355776898204284 no 2165 0.368773601712304 721 647478 SGTC_117 lucigenin 22.078 µM -0.33527099782683 0.355715231816428 no 2166 0.368710334657849 727 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1737 st035557 69.7 µM -0.335821895442176 0.35551274428198 no 2167 0.36850258896057 678 5716916 SGTC_1470 k295-0292 231 µM -0.336185496647291 0.355379121615174 no 2168 0.368365494539034 679 5045612 SGTC_1701 st028638 40.4 µM -0.336359040608865 0.355315350845795 no 2169 0.368300066369373 704 3490878 SGTC_687 k029-0044 34.9 µM -0.338011166973136 0.354708460675265 no 2170 0.367677386264412 714 5829338 SGTC_3131 9127911 49.47 µM -0.338554418638611 0.354508983690593 no 2171 0.36747271266406 722 45595681 SGTC_1081 sertraline 6 µM -0.338712116462685 0.354451085978378 no 2172 0.367413306029271 699 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_712 r015-0009 80.6 µM -0.342329077996922 0.353124068093427 no 2173 0.366051627482164 683 6813872 YLR060W FRS1 SGTC_611 3453-1652 23.7 µM -0.343152569459995 0.352822188156131 no 2174 0.36574184233341 706 1560575 SGTC_1741 st038134 10.228 µM -0.343238435226577 0.352790716350867 no 2175 0.365709545954585 718 1272587 SGTC_1685 st024049 53.0905 µM -0.343515582287537 0.352689142365596 no 2176 0.365605310132713 713 1941139 SGTC_1661 st013063 9.66 µM -0.343564876741611 0.352671077121325 no 2177 0.36558677138332 710 721395 SGTC_93 0109-0045 59.227 µM -0.346701243472135 0.351522357964647 no 2178 0.364407887971944 703 88733 SGTC_2104 5389443 200 µM -0.347985686980425 0.351052310721205 no 2179 0.363925466333133 715 2244536 SGTC_1004 4084-0029 199 µM -0.348684809802304 0.350796559621753 no 2180 0.363662974711508 686 716894 YLR208W SEC13 SGTC_3065 9113888 49.47 µM -0.3492099324519 0.350604505209574 no 2181 0.363465855007969 733 16648368 SGTC_2399 5884133 200 µM -0.354265917092911 0.348757327158158 no 2182 0.361569803881983 720 722445 SGTC_3200 9114385 49.47 µM -0.354780263830458 0.348569613081231 no 2183 0.361377107505558 711 17018030 YLR208W SEC13 SGTC_285 1486-1325 46 µM -0.354995480597407 0.348491079367373 no 2184 0.361296488493543 690 22310230 SGTC_2035 5154463 94.595 µM -0.355326299223362 0.348370374599319 no 2185 0.361172577675031 734 2769623 SGTC_1998 st075797 76.8 µM -0.355369950670985 0.348354448777148 no 2186 0.361156228756213 723 24208315 SGTC_1150 3909-7983 10.9 µM -0.356070002316195 0.348099078027022 no 2187 0.360894070799762 692 23965914 SGTC_2453 5731132 22.18 µM -0.360436370365444 0.346507835753014 no 2188 0.359260416094955 737 1362040 SGTC_2393 9031399 185.94 µM -0.36048696380644 0.346489413705983 no 2189 0.359241501816639 729 1526623 YDL150W RPC53 SGTC_696 1560-0013 611 µM -0.360923172532446 0.346330596765343 no 2190 0.359078440183792 703 1650269 SGTC_542 3381-0244 89.3 µM -0.361256120960151 0.346209393501399 no 2191 0.358953996135633 732 1112843 SGTC_1416 3966-0321 25.3 µM -0.362481464351228 0.345763467297105 no 2192 0.358496136207383 711 582530 YLR208W SEC13 SGTC_1849 st056239 19.2 µM -0.362834797467951 0.345634922231486 no 2193 0.358364148038657 729 5393181 SGTC_2487 5918373 44.05 µM -0.362847886083346 0.345630160843162 no 2194 0.358359259089687 713 2876279 SGTC_957 1187-1561 14.1 µM -0.363675960479018 0.345328972866335 no 2195 0.358049998321891 706 1538454 SGTC_1089 terbinafine 2.25 µM -0.36384257912292 0.345268382008438 no 2196 0.35798778254009 707 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_557 1315-0110 16.2 µM -0.363952232149251 0.34522850885689 no 2197 0.357946839907579 694 6833801 SGTC_2009 4012297 12.05 µM -0.364670757346952 0.344967273927055 no 2198 0.357678594894623 724 45595307 SGTC_1659 st012954 42.1 µM -0.365906162598203 0.344518289162955 no 2199 0.357217548850825 729 24207262 SGTC_156 3474-0145 5.642 µM -0.36768400972553 0.343872548527313 no 2200 0.356554432499193 711 2265471 SGTC_662 k832-1615 104 µM -0.367999743148477 0.343757916972524 no 2201 0.356436712855167 715 5878478 SGTC_967 1306-0166 352 µM -0.370203169586287 0.342958331750381 no 2202 0.35561555755692 683 4437607 SGTC_1030 k029-0042 36.7 µM -0.370387342628657 0.342891530327025 no 2203 0.35554695169783 718 6080581 SGTC_2525 harmine 47.85 µM -0.370919649355677 0.342698484915254 no 2204 0.355348689709925 703 5280953 A monoamine oxidase inhibitor SGTC_663 1486-0733 13.9 µM -0.373275322035626 0.341844674495195 no 2205 0.354471770731776 720 722445 YPR165W RHO1 SGTC_1064 honokiol 6.76 µM -0.373428629504524 0.341789136375672 no 2206 0.354414727403599 718 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_814 3342-0569 96 µM -0.37585965991371 0.340908914479961 no 2207 0.353510615969424 703 4346283 SGTC_376 3970-0862 59.1 µM -0.376617387909113 0.340634734737131 no 2208 0.353228982010735 732 3135186 SGTC_2612 dictamnine 15.46 µM -0.376857265723593 0.340547953795367 no 2209 0.353139840452743 709 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2977 9011197 71.43 µM -0.377310100243049 0.340384154210679 no 2210 0.352971583520955 745 2704722 SGTC_12 0849-0099 9.267 µM -0.377877654506799 0.340178900646062 no 2211 0.352760741476026 722 6071388 SGTC_754 3474-0146 171 µM -0.37927302203637 0.339674473375655 no 2212 0.35224256551611 691 24762078 SGTC_2150 5556613 200 µM -0.380985672756028 0.339055740169515 no 2213 0.351606939872347 712 743190 SGTC_119 0121-0043 24.815 µM -0.38304406020781 0.33831267599835 no 2214 0.350843547764757 732 1092378 SGTC_1043 0916-0009 19.3 µM -0.383259172613698 0.338235058118592 no 2215 0.350763803917033 753 3101130 SGTC_497 capsazepine 133 µM -0.38329567206326 0.338221888895945 no 2216 0.350750273938501 685 2733484 A calcium channel blocker. SGTC_1009 4106-0057 9.87 µM -0.383680747752892 0.338082963314655 no 2217 0.350607541792436 737 2928005 SGTC_1405 3909-7894 12 µM -0.386967238754929 0.336898179085419 no 2218 0.349390230918109 719 7104060 SGTC_2629 bisabolol 100 µM -0.387371896522443 0.336752410979115 no 2219 0.349240453095218 745 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1923 st058458 19.1 µM -0.389028502754916 0.336155914798794 no 2220 0.348627530888191 748 3534982 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.389948758813893 0.335824735135376 no 2221 0.348287218938383 760 6728940 SGTC_159 3970-0959 50 µM -0.390361889037266 0.335676100202857 no 2222 0.348134482512915 701 6615653 SGTC_2080 5212524 12.4 µM -0.390739461169746 0.335540280749996 no 2223 0.347994913642146 714 260183 SGTC_3319 9138450 16.7555 µM -0.391718540184377 0.335188188639771 no 2224 0.347633094776199 724 2029690 SGTC_249 wiskostatin 11.211 µM -0.39209385995114 0.335053256150922 no 2225 0.347494432043533 707 2775510 A n-wasp and actin depolymerizer. SGTC_870 0573-2213 57.6 µM -0.392158055198542 0.335030179229917 no 2226 0.347470717007867 705 3916321 SGTC_588 3970-1144 52.9 µM -0.392788751015291 0.334803489692636 no 2227 0.347237756848841 699 1888707 SGTC_949 1165-0505 146 µM -0.394482739923413 0.334194921291731 no 2228 0.346612333897414 705 6244267 SGTC_1448 4255-0083 152 µM -0.395573320615365 0.333803358703588 no 2229 0.346209911035571 752 5399660 SGTC_47 0149-0135 24.25 µM -0.396220840769176 0.333570958337861 no 2230 0.345971059033607 709 5239155 SGTC_361 000s-0510 1.45 µM -0.396310890674748 0.333538643733553 no 2231 0.34593784700322 711 660 SGTC_630 4356-0227 183 µM -0.397746444385887 0.333023659086419 no 2232 0.345408549094285 742 779312 SGTC_2836 9010338 19.48 µM -0.397917686605355 0.33296224934869 no 2233 0.345345431135843 694 2994051 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.397973543038861 0.33294221945747 no 2234 0.345324844012045 708 66535 A nucleotide analog. SGTC_1767 st044992 70.3 µM -0.398646953688398 0.332700774650236 no 2235 0.345076679657873 735 9600693 SGTC_2260 7964312 200 µM -0.400881435657111 0.331900120429563 no 2236 0.344253709215797 724 231951 SGTC_2125 5246583 200 µM -0.401003170928267 0.331856522539923 no 2237 0.344208894665079 760 835267 SGTC_164 4100-3994 89.624 µM -0.402310649715722 0.331388409825561 no 2238 0.343727708976612 745 4615967 SGTC_1012 4112-3522 18 µM -0.403178805370302 0.331077732061053 no 2239 0.343408345203762 710 3112398 SGTC_1618 st003135 44.5 µM -0.403265466283417 0.331046726007184 no 2240 0.343376471849405 759 1270615 SGTC_694 1315-0438 43.2 µM -0.404074418982819 0.33075735003939 no 2241 0.343078997744147 745 6793154 SGTC_2158 5657123 3.6195 µM -0.404878485424802 0.330469822161586 no 2242 0.342783416791985 770 2858827 SGTC_638 3970-0837 4.09 µM -0.405684967943105 0.3301815308019 no 2243 0.342487044316468 708 4118451 YLR208W SEC13 SGTC_2179 6298986 200 µM -0.405813454392641 0.330135610364573 no 2244 0.342439836064708 717 738374 SGTC_284 0988-0104 32.6 µM -0.406264796218409 0.329974323257864 no 2245 0.342274024406516 722 4666532 SGTC_727 3032-0951 202 µM -0.408776411328422 0.329077374913636 no 2246 0.341351876138738 730 3652836 SGTC_2809 7964133 12.99 µM -0.41144935047493 0.328123894305136 no 2247 0.340371536696305 738 1253665 SGTC_2812 7970281 58.44 µM -0.412394280337079 0.327787089896372 no 2248 0.340025227381305 741 2233435 SGTC_2462 5162487 171.77 µM -0.412524157285968 0.327740808376127 no 2249 0.339977639048702 735 2259986 SGTC_3108 9121785 49.47 µM -0.413360031745733 0.327443008693859 no 2250 0.339671426553412 677 17140271 SGTC_2174 5790901 200 µM -0.413721283335155 0.327314338388534 no 2251 0.339539119132146 721 786020 SGTC_2330 7979373 200 µM -0.413754975533407 0.327302338973704 no 2252 0.339526780463153 709 1863007 SGTC_580 1123-0028 41 µM -0.415002982527945 0.326857989386427 no 2253 0.339069859879868 735 1677248 YPR107C YTH1 SGTC_578 3460-0051 92 µM -0.415576998811957 0.326653694766109 no 2254 0.338859780316418 759 2876744 SGTC_319 1348-1596 45.5 µM -0.418835407401352 0.3254950007942 no 2255 0.337668213007483 749 5380505 SGTC_367 0335-0881 7.1 µM -0.419469504833533 0.325269710440859 no 2256 0.337436518509839 756 23828853 SGTC_259 usnic acid 108.925 µM -0.419743430442173 0.32517240634411 no 2257 0.337336447179151 771 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_124 0136-0217 7.121 µM -0.420236073293469 0.324997439315596 no 2258 0.337156502361626 747 3976905 SGTC_660 4031-1742 102 µM -0.420308130232366 0.324971850808192 no 2259 0.33713018566024 710 6738706 SGTC_1547 harmine 94.2 µM -0.420659365322434 0.324847133745218 no 2260 0.33700191867125 707 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_503 tyrphostin 8 294 µM -0.4207736964944 0.324806541101704 no 2261 0.336960170338311 765 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1982 st072467 71.9 µM -0.420890620236418 0.32476503013226 no 2262 0.336917477398685 740 3163533 SGTC_1420 4'-methoxyflavone 42 µM -0.420901808604343 0.324761058084725 no 2263 0.336913392245138 742 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2017 5132927 60.65 µM -0.421504642576257 0.324547071962564 no 2264 0.3366933109068 736 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_920 mycophenolic acid 780.421 nM -0.421725347351555 0.324468743544852 no 2265 0.336612750458498 722 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_398 bronopol 33.3 µM -0.42181409007522 0.324437250822998 no 2266 0.336580360188894 716 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2038 4100038 30.985 µM -0.422136288370155 0.324322920722514 no 2267 0.336462770998612 716 3596803 SGTC_3081 9117243 49.47 µM -0.423680838610073 0.323775076616009 no 2268 0.3358992956426 740 45595589 SGTC_2329 6138490 200 µM -0.425453265327823 0.323146876096113 no 2269 0.335253141760997 754 720019 SGTC_3055 9094636 49.47 µM -0.425741641368502 0.323044714715633 no 2270 0.335148057743896 722 25236176 SGTC_1638 st008370 60.6 µM -0.426753113840573 0.322686491527037 no 2271 0.33477957994605 705 24207134 SGTC_2624 nerol 100 µM -0.427360172701204 0.322471574469489 no 2272 0.334558505717248 767 637566 A natural product oil. SGTC_2060 5238662 140 µM -0.427391887533003 0.322460348096813 no 2273 0.334546957618848 749 790130 SGTC_2109 5483026 200 µM -0.428748973581366 0.321980120424667 no 2274 0.334052958207335 761 759335 SGTC_1712 st032288 53.4 µM -0.428882663636427 0.321932828019704 no 2275 0.334004308584212 739 2883011 SGTC_1602 st001878 87.6 µM -0.429469276586271 0.321725349770052 no 2276 0.333790873937622 771 595405 YLR310C CDC25 SGTC_3061 glucosamine 200 µM -0.430486001115197 0.321365877682012 no 2277 0.333421073855974 732 91431 and experimental redox chemotherapeutic SGTC_2057 5236571 38.335 µM -0.430618236554675 0.321319136939287 no 2278 0.33337298945267 728 54684039 YBR257W POP4 SGTC_1187 1391-0724 117 µM -0.430825690826167 0.321245814592816 no 2279 0.333297558953058 728 6997986 SGTC_2777 climbazole 1.536 µM -0.432429829182248 0.320679085582158 no 2280 0.332714521072444 738 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1196 1588-0294 184 µM -0.432661731379854 0.320597190953909 no 2281 0.332630267644203 755 6144269 SGTC_800 3448-7362 155 µM -0.435037884949102 0.31975857277712 no 2282 0.331767464326558 752 15991913 SGTC_1776 st049249 45.9 µM -0.43584221426546 0.319474908380396 no 2283 0.331475606668992 723 1822314 SGTC_2140 5586273 200 µM -0.436667910024421 0.31918381848483 no 2284 0.331176102427523 735 854421 SGTC_1423 4048-0112 5.59 µM -0.439163898871482 0.318304563446011 no 2285 0.330271390710287 730 X1423 SGTC_598 3937-0236 20.2 µM -0.439327451398623 0.318246984900802 no 2286 0.330212142990777 750 1379313 SGTC_1717 st033143 58.0435 µM -0.4393900453093 0.318224949923032 no 2287 0.330189469160422 753 674616 SGTC_853 0419-0306 21 µM -0.439480308939719 0.318193175487261 no 2288 0.330156773431857 745 762713 SGTC_422 cantharidin 155 µM -0.439589552061155 0.318154721715625 no 2289 0.33011720459505 729 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2337 9009472 200 µM -0.441203471915856 0.317586847626417 no 2290 0.329532849973801 752 5742383 SGTC_89 0302-0250 142.109 µM -0.441555454822469 0.31746305579648 no 2291 0.329405462150388 736 4203518 YLR208W SEC13 SGTC_2514 salinomycin 42.74 µM -0.442217585272312 0.317230240889838 no 2292 0.329165880999405 738 23682228 A polyether potassium ionophore. SGTC_312 4092-0653 6.84 µM -0.442257450380817 0.317216226032193 no 2293 0.329151458695027 742 1148278 SGTC_2207 7258803 200 µM -0.443009021789617 0.316952054920867 no 2294 0.32887960457924 760 3666799 SGTC_251 melphalan 456.522 µM -0.443095661511946 0.316921607771825 no 2295 0.328848271569201 736 460612 A DNA alkylator. SGTC_1693 xanthone 101.9 µM -0.444855379851688 0.316303471674516 no 2296 0.328212134999382 759 7020 An insecticide. SGTC_1630 st005209 31.3 µM -0.445179515601938 0.316189668432419 no 2297 0.328095014465434 741 3367314 SGTC_1777 st045864 34.765 µM -0.446132966295093 0.315855015265594 no 2298 0.327750600470932 746 4691462 SGTC_1672 st016598 6.51 µM -0.446373659721752 0.315770557740436 no 2299 0.327663678181869 755 4665860 YNL267W PIK1 SGTC_2391 6285546 200 µM -0.447039287714868 0.315537043940617 no 2300 0.327423346720207 725 846083 SGTC_855 0428-0020 25 µM -0.447296115514159 0.31544696399448 no 2301 0.327330635657286 715 6812414 SGTC_574 1315-0397 40 µM -0.449801444948602 0.314568819120436 no 2302 0.326426807935134 726 6794277 SGTC_848 0368-0089 85.6 µM -0.449835931743635 0.314556738429324 no 2303 0.326414373501393 757 762535 SGTC_2570 licareol 100 µM -0.450296468207241 0.314395431981754 no 2304 0.326248342636732 746 443158 SGTC_1053 3366-3204 134 µM -0.451367196468088 0.314020538142004 no 2305 0.325862460849539 726 3632071 YPR165W RHO1 SGTC_1931 st074438 57.1 µM -0.458031324720779 0.311691553580261 no 2306 0.323464968251451 778 2787313 SGTC_907 3448-6986 75.5 µM -0.458306343170689 0.311595600715594 no 2307 0.323366183790941 764 590582 SGTC_1862 st057513 3.81 µM -0.458673828113914 0.311467406619626 no 2308 0.323234205528568 730 5393163 SGTC_859 0439-0102 54.6 µM -0.460082552219556 0.310976196644972 no 2309 0.322728483622804 750 610143 SGTC_3303 9125618 40.5795 µM -0.460627338550774 0.310786324540493 no 2310 0.322532997032719 747 22695467 SGTC_2071 5230951 39.92 µM -0.460771533287645 0.310736077380408 no 2311 0.32248126360175 743 1799272 SGTC_655 k060-0012 42 µM -0.461731461657155 0.3104016636719 no 2312 0.322136953182782 735 5994525 SGTC_230 MPP+ 141.667 µM -0.462215204004913 0.31023319995563 no 2313 0.321963500610289 758 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3068 9116768 49.47 µM -0.464199932281184 0.309542433589757 no 2314 0.321252254862079 774 41904888 SGTC_974 1326-0144 138 µM -0.464613363855035 0.309398627071433 no 2315 0.321104180186063 757 5411856 SGTC_3218 9131285 49.47 µM -0.465093408545475 0.309231686710025 no 2316 0.320932283036794 773 17156417 SGTC_3324 9138759 60.749 µM -0.467229746643151 0.308489231609506 no 2317 0.320167756693691 742 45595710 SGTC_2127 5253358 187.912 µM -0.468096105567547 0.308188363224841 no 2318 0.319857932065719 741 20612 SGTC_782 0083-0095 30.5 µM -0.46844070521383 0.308068726756233 no 2319 0.319734732304761 758 3591729 An indicator and reagent. SGTC_1719 st032227 49.2 µM -0.469963867592363 0.307540166877236 no 2320 0.319190416303221 718 3125804 SGTC_858 0438-0351 2.77 µM -0.472908733743201 0.30651938778323 no 2321 0.318139146826424 741 2799119 SGTC_587 k089-0003 57 µM -0.473216682212714 0.306412730048672 no 2322 0.318029298587936 745 9659696 SGTC_1488 4013-0813 75.9 µM -0.473969003194177 0.306152233190114 no 2323 0.317761005652001 734 2910057 SGTC_1835 st008666 49.2 µM -0.4756562753979 0.305568358806125 no 2324 0.31715963812288 738 690455 SGTC_1689 st020265 53.493 µM -0.476190394549342 0.305383631713941 no 2325 0.316969371019666 762 5758320 YPR016C TIF6 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.477741730907567 0.304847377333588 no 2326 0.316417019263978 748 75037 A free radical scavenger. SGTC_416 estradiol valerate 100 µM -0.477855252077747 0.304808152618544 no 2327 0.31637661622081 756 13791 A steroid. SGTC_2193 5925765 200 µM -0.478031562389753 0.304747236960192 no 2328 0.316313870392513 745 877370 SGTC_466 geldanamycin 89.2 µM -0.478387789060418 0.304624176262601 no 2329 0.316187111542918 734 5288382 HSP90 inhibitor. SGTC_531 3788-1495 174 µM -0.478914819674951 0.304442150841926 no 2330 0.315999613846187 711 2896655 SGTC_1148 3909-7663 27.7 µM -0.479231478534634 0.304332806739619 no 2331 0.315886981272065 780 4084526 SGTC_847 0342-0274 5.54 µM -0.480528590514492 0.303885089245367 no 2332 0.315425789242061 743 18097 SGTC_487 nimodipine 119 µM -0.480966311693133 0.303734069589988 no 2333 0.315270220993315 741 4497 L-type voltage-gated calcium channels inhibitor SGTC_632 0781-2353 4.65 µM -0.481583296509803 0.303521258480014 no 2334 0.315050997187716 754 6811515 YHR007C ERG11 SGTC_1258 0671-0043 57.1 µM -0.483916504310511 0.302717088567262 no 2335 0.314222563414517 776 4298767 SGTC_2959 9079155 11 µM -0.484558227413076 0.302496077955714 no 2336 0.313994875602158 784 16189457 SGTC_2167 5876490 200 µM -0.485789397494654 0.30207226339112 no 2337 0.313558246155874 784 686534 SGTC_392 N-ethylmaleimide 8.33 µM -0.486311742874698 0.301892533263875 no 2338 0.313373077345707 732 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1231 0242-0792 125 µM -0.48651736546396 0.301821795224408 no 2339 0.313300198070805 770 3707635 SGTC_3347 9188721 44.724 µM -0.487046607893174 0.301639760143384 no 2340 0.313112651027459 769 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1820 st053765 18.6 µM -0.48768927863707 0.3014187773444 no 2341 0.312884973510526 749 3690829 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.488122555810338 0.301269835813047 no 2342 0.312731517643412 776 229346 A bile salt which induces apoptosis. SGTC_829 1635-0120 117 µM -0.488898636018388 0.301003136649683 no 2343 0.312456730706568 768 285054 SGTC_3216 9129716 49.47 µM -0.489653751206178 0.300743744301948 no 2344 0.312189466914449 732 8056934 SGTC_1135 dihydrocapsaicin 536.708 nM -0.490178771594848 0.300563452118342 no 2345 0.312003700586255 767 107982 A Capsaicinoid. SGTC_1082 camptothecin 424.86 nM -0.490829522112893 0.300340051924435 no 2346 0.311773513905699 773 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2686 alizarin 95.37 µM -0.491448566731876 0.300127605915914 no 2347 0.311554610617331 723 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2888 9058547 12.99 µM -0.4915728515672 0.300084961582577 no 2348 0.311510669694528 735 16476514 SGTC_1871 st057448 67.3 µM -0.492027284540481 0.299929060898957 no 2349 0.311350027702658 787 691747 SGTC_1123 mangostin 811.285 nM -0.492234824047767 0.299857873263083 no 2350 0.311276674461129 727 5281650 An antioxidant. SGTC_180 1486-1293 102.781 µM -0.493219022769456 0.299520389780711 no 2351 0.310928919062441 762 4140536 SGTC_1432 4049-0298 68.4 µM -0.494833791138988 0.298967056140716 no 2352 0.31035872478509 772 741646 SGTC_183 3914-0051 30.55 µM -0.496002089309133 0.298567004411779 no 2353 0.309946468433027 765 1596232 SGTC_3252 9135871 49.47 µM -0.4963523731763 0.29844710675145 no 2354 0.309822910589463 765 17682838 SGTC_570 0987-0065 62.6 µM -0.496700402436824 0.298328002516733 no 2355 0.309700169301013 733 3104428 SGTC_1281 0884-0031 11.8 µM -0.499500475213601 0.297370536645418 no 2356 0.308713426039927 748 1548255 SGTC_2519 cryptotanshinone 88.04 µM -0.500209360964865 0.297128360834777 no 2357 0.308463833847817 769 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2685 mycophenolic acid 18.85 µM -0.500701765303809 0.296960194406205 no 2358 0.308290514855996 750 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1198 1612-1005 86.7 µM -0.501201953788175 0.296789414122367 no 2359 0.308114499705744 757 6998509 SGTC_923 1900-2434 73.3 µM -0.502710999422751 0.296274450502656 no 2360 0.307583737581713 801 5910570 SGTC_1874 staurosporine 7.6 µM -0.504697394564685 0.295597216226894 no 2361 0.306885695651013 785 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2325 6158266 200 µM -0.505794293972175 0.295223548622563 no 2362 0.306500532310212 740 3623240 SGTC_2200 6600604 21.907 µM -0.505857938096182 0.295201874415639 no 2363 0.306478190977665 792 2904777 SGTC_2594 a-mangostin 100 µM -0.508181099180415 0.294411216507099 no 2364 0.305663172343372 789 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2934 9036370 36.88 µM -0.509142778397833 0.294084207747664 no 2365 0.305326074273859 744 6462800 SGTC_1248 0469-0687 58.6 µM -0.509551364916402 0.293945323093254 no 2366 0.305182902098488 766 4017482 SGTC_3017 9080681 49.47 µM -0.511265878573131 0.293362865251505 no 2367 0.304582447139446 780 16451914 SGTC_2606 farnesol 9.78 µM -0.51290008954816 0.292808186315701 no 2368 0.30401060539864 781 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1463 k081-0032 34.1 µM -0.513067687189946 0.292751328371399 no 2369 0.303951986839897 770 977755 SGTC_955 1216-0110 33 µM -0.513289294748995 0.292676155291965 no 2370 0.303874485637657 754 3619719 SGTC_2347 9049783 174.81 µM -0.514855938452257 0.292144978838031 no 2371 0.303326846311993 798 6467988 YPL169C MEX67 SGTC_1430 4049-0248 69.1 µM -0.515241552880639 0.292014303645406 no 2372 0.303192117785755 775 22774488 SGTC_1410 3909-8106 77.9 µM -0.518239490708945 0.290999306069259 no 2373 0.302145592452078 782 1039210 SGTC_2195 6536160 144.242 µM -0.518579050566819 0.290884446898402 no 2374 0.30202716061025 745 3834386 SGTC_462 ag-879 158 µM -0.518777437116921 0.290817350674476 no 2375 0.301957976908848 783 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_517 1365-0151 113 µM -0.519672177142123 0.29051483100202 no 2376 0.301646041094405 764 768657 SGTC_2800 7887935 81.82 µM -0.520721764030603 0.290160144036469 no 2377 0.30128030540391 789 2961002 SGTC_2549 cedrol 20.94 µM -0.521119190787479 0.290025894568024 no 2378 0.301141871491118 777 6708665 A sedative which affects the nervous system. SGTC_1565 sinapyl alcohol 95.1 µM -0.523115002417348 0.289352156550002 no 2379 0.300447112997907 771 5280507 A phenol propionate derived from cinnamic acid. SGTC_426 0988-0037 14.6 µM -0.5245496391524 0.288868312447072 no 2380 0.299948151864246 783 5383008 SGTC_2648 atorvastatin 78.68 µM -0.525031238148093 0.288705974280135 no 2381 0.299780737700247 787 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2882 9058044 58.44 µM -0.525890635505909 0.288416394014126 no 2382 0.299482097876824 766 18076804 SGTC_2598 perillyl alcohol 100 µM -0.526798885914921 0.288110501247057 no 2383 0.299166628328098 751 10819 An apoptosis inducer. SGTC_1478 0453-0656 35.7 µM -0.528426293488444 0.287562784305504 no 2384 0.298601745996519 792 5258496 SGTC_1806 st050005 60.3 µM -0.529920845539258 0.287060214973157 no 2385 0.298083406266981 759 5194765 SGTC_1742 st038235 28.8875 µM -0.531193129822717 0.286632715104647 no 2386 0.297642476646502 791 564103 YBR002C RER2 SGTC_1827 berberine 7.24 µM -0.532516786741001 0.286188274252069 no 2387 0.297184059236839 763 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1760 st045453 10.4495 µM -0.53560487595153 0.285152669032445 no 2388 0.296115829081946 781 3323419 YIL048W NEO1 SGTC_2302 7771753 200 µM -0.535682328396516 0.285126717968089 no 2389 0.296089059437724 750 2203047 SGTC_3075 9116269 49.47 µM -0.535963872813076 0.285032393732813 no 2390 0.295991759486558 790 17015205 YNL244C SUI1 SGTC_3181 9108277 49.47 µM -0.536058836231523 0.28500058203109 no 2391 0.295958944046802 789 17097298 SGTC_519 k048-0011 62.8 µM -0.538008669654684 0.284347783815016 no 2392 0.2952855316256 761 6836379 SGTC_160 3453-0671 289.699 µM -0.539248335805097 0.283933119334705 no 2393 0.29485775614574 802 5322268 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.539325342393499 0.283907370419431 no 2394 0.294831192666778 775 5024745 SGTC_2645 abamectin 100 µM -0.540570588758853 0.283491149028805 no 2395 0.294401797258777 777 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_683 panaxydol 45 µM -0.541412055786604 0.283210055847353 no 2396 0.294111799709929 762 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2699 st077704 54.6 µM -0.543724630496543 0.282438226587536 no 2397 0.293315490247702 777 645852 SGTC_2478 5763493 32.33 µM -0.544583980788078 0.282151673689819 no 2398 0.293019837351066 770 1365576 YLR208W SEC13 SGTC_3215 9129942 49.47 µM -0.54667797245361 0.281454012568838 no 2399 0.292299995045179 797 17682944 SGTC_2852 9023854 51.95 µM -0.547418595045234 0.28120745665866 no 2400 0.292045591514225 806 19798528 SGTC_1768 st044301 37.178 µM -0.548191506235186 0.280950263027524 no 2401 0.291780206829325 821 3931349 SGTC_3100 9120536 49.47 µM -0.549525334447292 0.280506686427801 no 2402 0.291322491667213 794 16421196 SGTC_2906 7926292 26.41 µM -0.550240382043461 0.280269030547783 no 2403 0.291077254693777 817 2966319 SGTC_1075 aripiprazole 15.2 µM -0.551356533515949 0.279898257343036 no 2404 0.290694645601238 765 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3093 9117344 49.47 µM -0.552020175513952 0.279677915616781 no 2405 0.290467265225715 750 24824913 SGTC_452 diindolylmethane 8 µM -0.553951357579337 0.279037205875944 no 2406 0.289806067918447 777 3071 Inhibits expression of several cancer promoting factors. SGTC_1333 1482-0047 286 µM -0.554668937568341 0.278799315847017 no 2407 0.28956056323937 793 3811116 SGTC_380 3970-0968 6 µM -0.555067469883016 0.278667238221145 no 2408 0.289424256104221 788 2891601 SGTC_365 0121-0052 13.6 µM -0.555722421010013 0.278450247012976 no 2409 0.289200313385468 761 3101739 SGTC_2402 5553605 200 µM -0.555964903740496 0.278369931187685 no 2410 0.289117423680362 771 6758546 SGTC_1140 3229-1848 2.98 µM -0.556615806858897 0.278154393038335 no 2411 0.288894975809393 789 2849525 SGTC_1788 fluconazole 20 µM -0.556715079374523 0.27812152738357 no 2412 0.288861056243588 805 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2775 cyproheptadine 69.59 µM -0.559231613243987 0.277289024306143 no 2413 0.288001830279197 793 2913 A selective serotonin reuptake inhibitor. SGTC_2245 6637752 200 µM -0.55936173637184 0.277246010994193 no 2414 0.287957434863208 760 681890 SGTC_1641 st009299 47.1 µM -0.559373999552467 0.277241957463323 no 2415 0.287953251077163 767 4046054 SGTC_382 3229-0966 23.2 µM -0.561338023058837 0.276593134036507 no 2416 0.287283562774455 799 5722370 SGTC_2802 7925815 54.55 µM -0.561760090562803 0.276453799481164 no 2417 0.287139743416511 774 1262923 SGTC_2297 7971671 152.32 µM -0.563132126241721 0.276001095711345 no 2418 0.286672458386681 797 909016 SGTC_892 0929-0076 29 µM -0.563522975382973 0.275872201524061 no 2419 0.286539409829227 769 5751038 SGTC_1700 st030840 7.9285 µM -0.563781404815644 0.275786992938135 no 2420 0.286451454220744 775 5499307 SGTC_2247 cerulenin 830 nM -0.564244814048568 0.275634231417489 no 2421 0.286293766503673 753 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1919 st067113 52.3 µM -0.56457508472868 0.275525384034528 no 2422 0.286181407995019 777 1268243 SGTC_1688 st021091 57.6 µM -0.565638914767877 0.275174921112836 no 2423 0.285819634108546 806 3656366 SGTC_3225 9130819 49.47 µM -0.567616626763446 0.27452397730832 no 2424 0.285147657360657 804 4547121 SGTC_1968 st069590 43.6 µM -0.56803529107489 0.274386275708396 no 2425 0.285005502399997 788 6384066 SGTC_699 0375-0592 111 µM -0.568162676010669 0.274344384684292 no 2426 0.284962256314029 764 762578 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.570194949999328 0.273676490910134 no 2427 0.284272740435224 807 165506 SGTC_2782 7736369 71.43 µM -0.570974193600997 0.273420611032572 no 2428 0.284008568072114 786 2950836 YOL077C BRX1 SGTC_1351 1496-0003 46.5 µM -0.5721965967702 0.273019449844547 no 2429 0.283594396421089 789 3891978 SGTC_11 0438-0307 1.3 µM -0.572703417424682 0.272853209988012 no 2430 0.28342276158798 788 4011476 SGTC_2863 9028737 58.44 µM -0.573348161575675 0.272641803079509 no 2431 0.283204490950222 781 6460917 SGTC_856 0433-0016 11.3 µM -0.573510617406403 0.272588547822272 no 2432 0.283149506138994 787 3911780 SGTC_42 0133-0086 60.653 µM -0.573631658146591 0.272548872358981 no 2433 0.283108542012258 813 162923 Model of phenazepam hydroxylation. SGTC_1271 0832-2808 169 µM -0.573786508887126 0.272498118630462 no 2434 0.283056139627625 793 3663794 SGTC_2008 4012253 172 µM -0.575541610724372 0.271923196400605 no 2435 0.282462528670084 776 603940 SGTC_3213 9129884 49.47 µM -0.576070485221402 0.271750070301641 no 2436 0.282283770066101 787 17190742 SGTC_1091 telmisartan 47.6 µM -0.576618461311433 0.271570749217464 no 2437 0.282098612598885 814 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_935 2996-0153 430 µM -0.577202427512149 0.27137971551918 no 2438 0.281901358698658 801 23738523 SGTC_3199 9111318 49.47 µM -0.577679970036427 0.271223546133063 no 2439 0.281740102321449 777 8548020 SGTC_1877 wortmannin 25 µM -0.577936177763757 0.271139777712398 no 2440 0.281653604525767 788 312145 A covalent inhibitor of PI 3-kinase. SGTC_2954 9074818 52.69 µM -0.578490445833023 0.270958601101427 no 2441 0.28146652298091 811 16648742 SGTC_2958 9077254 16.72 µM -0.579668263621279 0.270573802073808 no 2442 0.281069174511578 777 16457351 SGTC_1855 st056195 39.6 µM -0.580639427656765 0.27025672333915 no 2443 0.280741746706903 784 4028379 SGTC_695 3505-6186 243 µM -0.58098205619172 0.270144901707084 no 2444 0.280626273586808 800 1819379 SGTC_1557 sumaresinolic acid 42.3 µM -0.581292604923802 0.270043569766658 no 2445 0.280521631900613 772 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2274 7947094 46.08 µM -0.581837205575827 0.269865912700026 no 2446 0.280338170303307 772 2971028 SGTC_2241 6772625 37.8075 µM -0.58290815074563 0.269516724746514 no 2447 0.279977566686428 788 2285411 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.582910612284263 0.269515922408309 no 2448 0.279976738107841 807 23665772 A membrane-active detergent. SGTC_2702 st077768 96.8 µM -0.583009183682611 0.269483794057287 no 2449 0.279943558963796 760 6484119 SGTC_2640 pentamidine 10.38 µM -0.584446659722995 0.269015481495858 no 2450 0.279459921119174 798 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_584 0986-0246 15.4 µM -0.585287993649592 0.268741574565329 no 2451 0.279177043265328 814 53315 YDR232W HEM1 SGTC_1186 1319-0216 26 µM -0.586373673805123 0.268388324784495 no 2452 0.278812215818752 805 4565136 SGTC_3323 9138564 53.9225 µM -0.588626824482446 0.267655958888304 no 2453 0.278055817681881 775 43912313 YNL103W MET4 SGTC_1461 k072-0203 53.8 µM -0.589357829744611 0.267418568948092 no 2454 0.277810629469391 797 5418714 SGTC_797 k781-0471 270 µM -0.591088405605101 0.266856997572558 no 2455 0.277230594020414 774 23738129 SGTC_2188 6126565 140.678 µM -0.591518353966774 0.266717571911781 no 2456 0.277086580565709 785 874518 SGTC_803 4488-1585 147 µM -0.592894945524884 0.266271412195279 no 2457 0.276625730434546 783 747204 SGTC_1379 2144-0755 36.5 µM -0.593469244101084 0.266085391093024 no 2458 0.276433580036651 807 5392327 SGTC_3264 9137442 49.47 µM -0.594925562926092 0.265613969972117 no 2459 0.275946614521177 792 17015726 SGTC_2884 9058502 51.95 µM -0.596226381571194 0.265193243851043 no 2460 0.275512001893094 795 6471554 SGTC_2083 5306046 65.942 µM -0.599015485862692 0.264292300898482 no 2461 0.274581278943773 803 539837 SGTC_3001 9076041 71.4286 µM -0.59979670460783 0.264040229486236 no 2462 0.274320864907654 787 16004211 SGTC_633 0437-0093 97.7 µM -0.602136748477211 0.26328591457942 no 2463 0.273541557354051 809 2831118 SGTC_168 3970-0862 530.542 µM -0.602203467735227 0.263264423723943 no 2464 0.273519353837395 809 3135186 SGTC_2020 4017018 200 µM -0.607123388603256 0.261682147006244 no 2465 0.27188451481388 809 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3253 9135987 49.47 µM -0.608156190479247 0.261350612389504 no 2466 0.271541943778835 794 4182430 SGTC_91 0417-1751 58.384 µM -0.609007900241195 0.261077371665801 no 2467 0.271259601184078 814 6795624 SGTC_2442 5158906 48.48 µM -0.609118951767411 0.261041755566328 no 2468 0.271222798284617 798 1893835 SGTC_2698 st077697 67.5 µM -0.610566587948463 0.260577702825008 no 2469 0.270743273972944 806 3154499 SGTC_2505 galangin 7.89 µM -0.611304538170854 0.260341309803911 no 2470 0.27049899358549 799 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2427 5545055 42.75 µM -0.611709182772579 0.260211733938005 no 2471 0.270365092642178 794 5372858 SGTC_1867 st057372 64 µM -0.611897793839072 0.260151347994548 no 2472 0.270302690677678 775 688837 SGTC_2881 9058953 51.95 µM -0.612161535378936 0.260066920303286 no 2473 0.270215443874751 768 17122249 SGTC_2504 purpurogallin 52.29 µM -0.61301727191007 0.259793083291874 no 2474 0.269932459665882 778 5281571 An antioxidant. SGTC_3343 9148379 18.9835 µM -0.614806865789051 0.259220891783112 no 2475 0.269341137280898 798 1955036 SGTC_794 k038-0031 316 µM -0.61505238620501 0.259142441744186 no 2476 0.269260062467769 808 6624242 SGTC_2235 salicylic acid 500 µM -0.615293412399782 0.259065439664459 no 2477 0.269180483627093 798 338 A COX inhibitor and kinase inhibitor. SGTC_1540 guanosine 70.6 µM -0.615354256232107 0.259046003391994 no 2478 0.269160396880747 808 6802 Guanosine is a purine nucleoside SGTC_3260 9137109 49.47 µM -0.616553285232552 0.258663133197856 no 2479 0.268764707604342 798 17478346 SGTC_1259 0671-0132 43 µM -0.618336845355815 0.258094154828311 no 2480 0.268176659417171 787 X1259 SGTC_3116 9124943 49.47 µM -0.619482044741463 0.257729164100838 no 2481 0.267799423404733 781 41905195 YPL160W CDC60 SGTC_1372 2752-0194 270 µM -0.620164113725103 0.257511906759424 no 2482 0.267574872611551 796 823334 SGTC_316 k060-0003 58.6 µM -0.620637173522876 0.257361280361589 no 2483 0.267419187603841 805 6152314 SGTC_3178 9107506 49.47 µM -0.620842285681904 0.257295985079674 no 2484 0.267351698949055 797 8897194 SGTC_2497 7-hydroxyflavone 100 µM -0.621960764243151 0.256940080834397 no 2485 0.266983833913196 814 5281894 SGTC_851 0394-0702 453 µM -0.622908353693016 0.2566387547231 no 2486 0.26667237407721 821 762646 SGTC_1996 st072960 66.8 µM -0.623331994275808 0.256504099846414 no 2487 0.266533188587726 779 1719405 SGTC_2848 9016370 25.97 µM -0.627432885611824 0.255202529645043 no 2488 0.265187758417418 796 7894410 SGTC_761 k216-0224 480 µM -0.629020820429471 0.254699468654948 no 2489 0.264667712813324 847 1340404 SGTC_324 1315-0088 19.6 µM -0.629068635238051 0.254684328883483 no 2490 0.264652061603385 817 6787421 SGTC_1761 st044296 37 µM -0.630143311437462 0.254344174736994 no 2491 0.264300412334991 818 1826700 SGTC_3166 9102297 49.47 µM -0.630663990065281 0.254179456362706 no 2492 0.264130124510136 803 25237072 SGTC_152 4469-0003 551.229 µM -0.631528416800155 0.253906115742253 no 2493 0.263847537418502 801 697280 SGTC_735 3076-0345 636 µM -0.634183343854329 0.25306756601717 no 2494 0.262980588145425 803 2888990 SGTC_3219 9131112 49.47 µM -0.635141235972015 0.2527653770811 no 2495 0.262668152506522 807 17612988 YMR079W SEC14 SGTC_511 blebbistatin 171 µM -0.637142215097706 0.252134736041557 no 2496 0.262016106499349 810 3476986 A myosin inhibitor. SGTC_2182 6325192 200 µM -0.638779293060289 0.251619402282538 no 2497 0.26148326039897 799 736248 SGTC_634 1611-4317 11.2 µM -0.639727417534609 0.251321197968581 no 2498 0.261174913694369 828 2843522 SGTC_631 k072-0230 41.5 µM -0.640236980921387 0.251161007208742 no 2499 0.261009271980191 811 5773147 SGTC_1917 st066507 28.5 µM -0.64214148726896 0.250562768538997 no 2500 0.260390660338379 797 3156428 SGTC_116 0155-0182 31.788 µM -0.643207332583437 0.250228297695937 no 2501 0.260044788005707 787 771486 SGTC_2148 5546263 113.568 µM -0.645329897086703 0.249562925737042 no 2502 0.259356711080953 803 792097 SGTC_2151 5563267 85.4165 µM -0.649338395996039 0.24830892781075 no 2503 0.258059836548893 829 5310824 SGTC_2995 9067767 71.4286 µM -0.649735412516187 0.24818491032237 no 2504 0.257931572597582 804 11673567 SGTC_3045 9092950 49.47 µM -0.649855260904664 0.248147479339306 no 2505 0.257892859731903 813 44120432 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.649956751218025 0.248115784294878 no 2506 0.257860079163364 819 688761 SGTC_418 lividomycin a 100 µM -0.650956334227233 0.247803733671926 no 2507 0.257537337310346 814 72394 An antibiotic. SGTC_992 3909-8734 162 µM -0.651021897764344 0.24778327331917 no 2508 0.257516175720116 827 4288319 SGTC_1073 triclabendazole 3.09 µM -0.651553088605932 0.247617538343063 no 2509 0.257344759417229 806 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1222 0366-0074 1.18 µM -0.651865869892097 0.247519976265562 no 2510 0.257243852041728 821 286520 SGTC_2766 oltipraz 83.91 µM -0.652080555830401 0.247453023769758 no 2511 0.257174603427158 819 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2074 5212007 75.395 µM -0.652095225782996 0.247448449114783 no 2512 0.257169871873967 805 758611 SGTC_1483 3453-0561 55.9 µM -0.652469873360857 0.247331634919468 no 2513 0.257049050767467 839 4546991 SGTC_223 busulfan 5 mM -0.654160719953798 0.246804800049698 no 2514 0.256504132625505 814 2478 A DNA alkylator. SGTC_3208 9114115 49.47 µM -0.655175411624483 0.246488930559281 no 2515 0.256177411697054 821 650895 SGTC_646 4092-0839 27.3 µM -0.656138103380161 0.2461894487925 no 2516 0.255867634962791 828 877796 SGTC_2788 5282734 71.43 µM -0.65634386614116 0.246125463803995 no 2517 0.255801449608099 832 743706 SGTC_3201 9113999 49.47 µM -0.657753433221788 0.24568737790826 no 2518 0.255348290698885 820 16649224 SGTC_1024 4507-0395 26 µM -0.657865273690937 0.245652636428104 no 2519 0.255312353304955 800 4201836 SGTC_2161 5662504 8.5105 µM -0.659325474478038 0.245199290234474 no 2520 0.254843393662864 810 2859334 SGTC_783 0848-0141 92.7 µM -0.660728977988463 0.244763971108682 no 2521 0.25439306830104 831 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1961 st076550 68.7 µM -0.660865008987652 0.244721801040283 no 2522 0.254349443844276 825 1579337 SGTC_1505 k297-0037 20.6 µM -0.664362643062001 0.243638867229175 no 2523 0.253229118195581 813 4089396 SGTC_439 amiodarone 34.4 µM -0.664925507151845 0.243464835877918 no 2524 0.253049070141628 830 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3117 9124945 49.47 µM -0.667855846521004 0.242559893257063 no 2525 0.252112807046273 809 17592065 SGTC_3101 9120531 49.47 µM -0.668390395695346 0.24239501132938 no 2526 0.251942212283692 848 24824904 SGTC_2408 sulbentine 18.36 µM -0.669066759100871 0.242186473796396 no 2527 0.251726446601351 814 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3235 9132602 49.47 µM -0.669327940675666 0.242105971879695 no 2528 0.251643153579615 823 4912240 SGTC_1812 st052057 4.327 µM -0.669456854730112 0.242066243076054 no 2529 0.25160204715964 815 3645418 SGTC_2737 bleomycin 30.5 nM -0.669819623381881 0.241954463809372 no 2530 0.251486391296311 821 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1524 corynanthine 62.1 µM -0.670794553943154 0.241654198953436 no 2531 0.251175708669769 842 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1676 st018489 23.4 µM -0.670795324546065 0.24165396169865 no 2532 0.251175463180865 821 3696235 SGTC_1120 ficusin 1.78878 µM -0.672942960786705 0.240993234625238 no 2533 0.250491789737056 839 6199 A DNA cross-linker. SGTC_1500 4488-1866 171 µM -0.673664357732139 0.240771515210653 no 2534 0.250262363383057 849 2900003 SGTC_2480 5767542 37.17 µM -0.674285340960383 0.240580746618428 no 2535 0.250064960943935 826 2867358 SGTC_1317 1273-0028 910 nM -0.674538252920456 0.24050307461721 no 2536 0.249984587222601 825 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_334 1502-1024 68.5 µM -0.675629384696462 0.240168132829533 no 2537 0.249637990083962 823 3296216 SGTC_1559 coumarin 343 70.1 µM -0.675857116256377 0.240098258767401 no 2538 0.249565683545383 831 108770 A hepatotoxic, DNA x-linker. SGTC_2678 equilin 100 µM -0.676767871234951 0.239818925882072 no 2539 0.249276623031795 799 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3 0833-0587 95.581 µM -0.67729721465679 0.239656655238417 no 2540 0.249108698890047 826 5382644 SGTC_185 k048-0037 25.491 µM -0.67783939876631 0.239490510414702 no 2541 0.248936763686158 811 6827589 SGTC_844 0330-0132 15.3 µM -0.679953865713966 0.238843162563091 no 2542 0.24826683647043 824 2828079 SGTC_2522 biochanin a 4.94 µM -0.680812876031874 0.238580448650616 no 2543 0.247994950808315 815 5280373 A possible chelator. SGTC_2156 5649887 115 µM -0.680902028268529 0.238553191995056 no 2544 0.24796674230512 837 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1327 1436-0082 2.18 µM -0.68146783142769 0.238380247834187 no 2545 0.247787757440388 830 15992205 SGTC_221 trifluoperazine 10.304 µM -0.681850290618854 0.2382633837425 no 2546 0.247666810264955 844 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_667 1498-1044 59 µM -0.685723230218228 0.23708173954649 no 2547 0.246443827490095 849 6739982 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.686813873966309 0.23674956326959 no 2548 0.24610001288506 834 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2298 7976326 193.81 µM -0.687234003074219 0.236621673291876 no 2549 0.245967640032594 810 2235818 SGTC_619 1652-1634 108 µM -0.687860210355694 0.236431122370684 no 2550 0.245770407700799 835 5400454 SGTC_976 1348-1067 47.6 µM -0.688707575919289 0.236173408914231 no 2551 0.245503653859108 841 5310671 YGL099W LSG1 SGTC_2493 resveratrol 26.09 µM -0.688873523089764 0.236122956709296 no 2552 0.245451431290869 801 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_713 1488-1073 324 µM -0.690055176448909 0.23576387543243 no 2553 0.245079744782312 844 3312542 SGTC_1388 3346-4487 254 µM -0.691121246706147 0.235440176125985 no 2554 0.244744674632293 845 3345614 SGTC_2019 4016004 108 µM -0.692220441722555 0.235106675863859 no 2555 0.244399451644459 837 45595336 SGTC_1886 st057356 49.9 µM -0.696273949611562 0.233879083188134 no 2556 0.243128642042191 827 24207747 SGTC_2014 4013930 200 µM -0.696545090208615 0.233797095999196 no 2557 0.24304376481298 839 64556 SGTC_875 0709-0210 25.7 µM -0.696901878151047 0.233689235137341 no 2558 0.24293210115896 840 6251364 SGTC_2396 5342950 42.78 µM -0.697083079135799 0.233634466680314 no 2559 0.24287540145233 831 1886677 SGTC_862 0452-0056 10.2 µM -0.699078292446297 0.2330318792472 no 2560 0.24225155185713 835 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1314 1222-0010 41.1 µM -0.699421723004647 0.232928244669663 no 2561 0.242144258030981 841 3526027 SGTC_505 gw-5074 63.9 µM -0.702695110554153 0.231941743916684 no 2562 0.241122887703028 834 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_825 1988-2224 89.6 µM -0.703249876355682 0.231774785030355 no 2563 0.240950020732452 834 1180859 SGTC_2769 toremifene 3.73 µM -0.703269442805998 0.231768897655063 no 2564 0.240943924988753 836 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.706774278733962 0.230715667975712 no 2565 0.239853380605402 838 803109 SGTC_1306 1185-0270 9.02 µM -0.70798930680634 0.230351167932395 no 2566 0.239475948991883 840 1548076 SGTC_886 0866-0150 153 µM -0.70837105844845 0.230236711583283 no 2567 0.239357430129533 842 271463 SGTC_1101 ebselen 5.29 µM -0.708633352302459 0.230158089373182 no 2568 0.239276016782071 836 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1878 temozolomide 1 mM -0.708848316760973 0.2300936652824 no 2569 0.239209305279807 827 5394 DNA alkylating agent. SGTC_887 0885-0007 9.62 µM -0.711894588555842 0.229181793704245 no 2570 0.238265026694229 841 5719458 SGTC_3025 9087895 49.47 µM -0.713983235604165 0.228557750655741 no 2571 0.237618772948905 850 17173641 SGTC_913 3487-1245 167 µM -0.716014336891471 0.227951817490052 no 2572 0.236991248155514 837 4016153 SGTC_1713 st033146 12.748 µM -0.718211712508235 0.227297299032888 no 2573 0.236313378616037 855 674619 SGTC_2137 5261020 140 µM -0.718795186858978 0.227123681291079 no 2574 0.236133561852959 839 763655 SGTC_297 0986-0032 24 µM -0.723942004547605 0.225595444160986 no 2575 0.234550670395195 836 2847425 SGTC_330 1488-0319 80.1 µM -0.724326255898642 0.225481582871874 no 2576 0.234432730722777 843 6846614 SGTC_1493 4348-0038 111 µM -0.725064050238598 0.225263051008457 no 2577 0.234206368824756 865 800424 SGTC_2331 7980721 200 µM -0.725218194199569 0.225217409309566 no 2578 0.234159091366134 841 2981221 SGTC_1179 1021-1431 9.29 µM -0.725709485735652 0.225071973889013 no 2579 0.234008442719517 856 2840958 SGTC_1475 4092-1048 11.7 µM -0.725720825972186 0.225068617504484 no 2580 0.234004966006265 857 2881759 SGTC_2310 7668677 200 µM -0.726815624833171 0.224744722026108 no 2581 0.233669455050015 856 2197143 SGTC_2118 5526350 200 µM -0.727074523035267 0.224668165837154 no 2582 0.233590152376853 850 743594 SGTC_2634 4'-methoxyflavone 100 µM -0.728780540381941 0.224164066587779 no 2583 0.233067958432329 834 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2739 tacrine 100.86 µM -0.72952117703306 0.223945421113754 no 2584 0.23284145929768 830 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3328 9140624 29.0385 µM -0.729570033587135 0.223931002291746 no 2585 0.232826522443283 840 4904392 SGTC_3124 9127567 49.47 µM -0.729812707841549 0.223859390714161 no 2586 0.232752337831178 837 17592030 SGTC_863 0466-0191 129 µM -0.731318906601215 0.223415212550861 no 2587 0.232292192396637 859 765160 YPR165W RHO1 SGTC_2184 6075246 200 µM -0.733323170175995 0.222824933338536 no 2588 0.231680673219501 833 2267320 SGTC_20 0481-0013 4.944 µM -0.733670861657212 0.222722624628954 no 2589 0.231574680748148 844 182045 SGTC_141 0443-0274 32.331 µM -0.735467921351338 0.222194264251756 no 2590 0.231027284789167 809 1627241 SGTC_2974 9094440 9.66 µM -0.735843943813711 0.222083799015959 no 2591 0.230912837367229 852 25236134 SGTC_1205 4161-2785 76 µM -0.73604749104981 0.222024015420006 no 2592 0.230850898275366 838 3498106 SGTC_1125 tnp00248 1.32998 µM -0.736893317673235 0.221775687213348 no 2593 0.230593614019748 862 24207736 SGTC_1808 st050063 61.5 µM -0.737530618371374 0.221588685478031 no 2594 0.230399865250886 864 4011993 SGTC_1738 st035555 74 µM -0.738584733530172 0.221279576684605 no 2595 0.230079598622953 855 5331140 SGTC_3351 9150312 21.596 µM -0.738783058656857 0.2212214473902 no 2596 0.230019370328173 851 4904905 SGTC_3194 9111903 49.47 µM -0.739344319146361 0.221056988723737 no 2597 0.229848971962857 860 17087251 SGTC_2662 daunorubicin 22.37 µM -0.740234696011114 0.220796237069753 no 2598 0.229578799093575 820 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1361 1608-0041 5.61 µM -0.742999408920156 0.219987699480796 no 2599 0.228741019144478 846 X1361 SGTC_281 1672-3440 14.9 µM -0.744258329103824 0.219620093133404 no 2600 0.228360103050427 847 6833000 SGTC_1866 st057638 64 µM -0.746102430216945 0.219082250545354 no 2601 0.227802770700293 834 688802 SGTC_2524 avocatin b 10.57 µM -0.746865197980761 0.218860006606228 no 2602 0.227572467655851 832 6710748 SGTC_654 1124-0271 80.9 µM -0.747626745853536 0.218638247556208 no 2603 0.227342663782261 852 5403748 SGTC_368 fentichlor 4.58 µM -0.747909707722498 0.218555883401346 no 2604 0.227257310837166 870 7329 A pesticide. SGTC_1192 1488-0095 21.4 µM -0.749171759032604 0.218188744826612 no 2605 0.226876844188205 875 915875 SGTC_3238 9133470 49.47 µM -0.753930429063406 0.216807618763358 no 2606 0.225445498909154 830 3534688 SGTC_272 doxorubicin 8.13 µM -0.754324443646963 0.216693489524477 no 2607 0.22532721410729 863 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2268 7933382 153.85 µM -0.754387981255485 0.216675088640038 no 2608 0.225308143146323 855 935025 YOR257W CDC31 SGTC_3114 9122766 49.47 µM -0.755137018504946 0.216458230956531 no 2609 0.225083386789785 821 17176985 SGTC_3064 1327-0027 10 µM -0.757793589176014 0.215690126704328 no 2610 0.224287280416525 825 16000455 YPR107C YTH1 SGTC_3024 9090631 49.47 µM -0.758205412054406 0.215571196436703 no 2611 0.224164010894706 826 25236383 SGTC_3152 9099253 49.47 µM -0.758719663770282 0.215422739167059 no 2612 0.224010135735894 847 25236131 SGTC_3244 9134489 49.47 µM -0.758748648410038 0.215414373473438 no 2613 0.224001464695932 874 16584271 SGTC_2876 9059903 25.97 µM -0.759933700118398 0.215072499252399 no 2614 0.223647108141934 832 6916095 SGTC_199 4063-0024 41.6 µM -0.760080044689567 0.215030302337628 no 2615 0.22360337001634 853 306215 SGTC_1462 k081-0014 26.5 µM -0.761592730829208 0.214594416971968 no 2616 0.223151557335037 819 3270634 SGTC_3318 9139014 38.6185 µM -0.762949558258262 0.214203880098262 no 2617 0.222746739463287 874 16643984 SGTC_1453 4237-0541 195 µM -0.763307195468371 0.214101009957941 no 2618 0.222640105923139 845 739892 SGTC_1561 5-methoxyflavone 52.9 µM -0.763489950843669 0.214048453623449 no 2619 0.222585626597312 847 94525 SGTC_1523 st012844 44.7 µM -0.763942707523178 0.213918283336417 no 2620 0.222450692701569 868 4274103 SGTC_540 1187-0821 17.3 µM -0.766561004837369 0.213166411458424 no 2621 0.221671283926068 854 847520 SGTC_2602 kawain 100 µM -0.76794793706373 0.212768764398973 no 2622 0.221259058117656 844 5369129 SGTC_1902 st060212 70.5 µM -0.768010401220501 0.212750865509922 no 2623 0.221240502763796 847 688944 SGTC_336 4111-0029 111 µM -0.769312529279119 0.212377945405905 no 2624 0.220853900513669 864 3131175 SGTC_890 0929-0006 47.2 µM -0.772651467611703 0.211423444751939 no 2625 0.219864338110536 871 1378169 SGTC_177 1327-0068 8.361 µM -0.77406125540219 0.211021184938128 no 2626 0.219447284043141 854 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_925 2064-1272 59.6 µM -0.774093498153815 0.211011990248857 no 2627 0.219437751068186 873 6815817 SGTC_306 1672-3436 11.6 µM -0.774516852017473 0.210891283903611 no 2628 0.219312603248245 871 6797378 SGTC_622 1348-1566 26.3 µM -0.777594359146178 0.21001504500557 no 2629 0.218404093758936 863 7340407 SGTC_1238 0333-0287 48.8 µM -0.779943689129344 0.209347577502936 no 2630 0.21771201052215 855 7226 SGTC_1180 1193-0155 285 µM -0.780444544554525 0.209205441218724 no 2631 0.21756462857166 866 2921347 SGTC_801 0866-0028 10.1 µM -0.781368535148192 0.208943373781369 no 2632 0.217292885825523 850 6849771 SGTC_1861 st057647 17.4 µM -0.783440554749922 0.208356399381698 no 2633 0.216684224483096 842 688668 SGTC_522 1273-0010 11.6 µM -0.78345921466949 0.208351117708425 no 2634 0.216678747565332 845 5705015 SGTC_1305 1181-0477 144 µM -0.783796520505928 0.208255657215507 no 2635 0.21657975792586 874 6252086 SGTC_2211 7117706 200 µM -0.785561227017964 0.207756650707759 no 2636 0.216062293581553 859 822771 SGTC_2489 cantharidin 73.42 µM -0.788013119726997 0.207064501998689 no 2637 0.215344515901809 868 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1445 4239-0156 97.7 µM -0.788201923703209 0.207011260853159 no 2638 0.21528930203968 892 4008346 SGTC_686 1319-0111 510 µM -0.789008680383078 0.206783853473495 no 2639 0.215053466568423 908 4562600 SGTC_751 0833-0568 350 µM -0.789238144250205 0.206719199562633 no 2640 0.214986415860928 869 6954252 SGTC_3214 9129694 49.47 µM -0.790017979484984 0.206499562082413 no 2641 0.214758634123353 878 17158655 SGTC_3076 9116187 49.47 µM -0.790211051401356 0.206445205505913 no 2642 0.214702261494559 855 27241210 SGTC_2143 5623677 140.463 µM -0.790836276997284 0.206269240560931 no 2643 0.214519768795521 842 5375313 SGTC_1267 0828-0272 9.49 µM -0.791449439455489 0.206096757065614 no 2644 0.21434088473807 869 745334 SGTC_2743 auranofin 4.32 µM -0.79146828840168 0.206091456184781 no 2645 0.21433538712007 821 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_941 3237-0776 460 µM -0.791478466453349 0.206088593849408 no 2646 0.214332418551072 866 760008 SGTC_1830 st055982 50.3 µM -0.793465811844763 0.205530151926887 no 2647 0.213753240229043 888 455313 An antimicrobial agent. SGTC_2278 7948257 134.34 µM -0.794144980283094 0.205339512500237 no 2648 0.213555517217178 854 1247028 SGTC_2845 9003024 42.97 µM -0.794595229826984 0.205213187460358 no 2649 0.213424497018091 857 2990173 SGTC_2647 atorvastatin 60.16 µM -0.794987914999857 0.205103050773976 no 2650 0.213310266002938 857 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_115 0527-0192 112.043 µM -0.796159754851462 0.204774592928304 no 2651 0.212969593062598 888 4233931 SGTC_1326 1431-2094 10.8 µM -0.79691087601596 0.204564223974151 no 2652 0.212751396966874 890 616278 SGTC_195 4234-0266 16.654 µM -0.798345001227323 0.204162921197142 no 2653 0.212335155057201 868 2303354 SGTC_2147 5545932 89.7195 µM -0.800496939176743 0.203561637544995 no 2654 0.211711468119353 878 797404 SGTC_728 3030-5151 22.5 µM -0.800510898717405 0.203557740491536 no 2655 0.21170742578879 871 3125388 SGTC_2588 indole-3-carbinol 100 µM -0.802639697899903 0.202963969355353 no 2656 0.211091508147427 872 3712 Induces cell cycle arrest. SGTC_3129 9127257 49.47 µM -0.805245319336708 0.202238611120719 no 2657 0.210339064528128 882 837894 SGTC_1939 st074455 53.6 µM -0.806122623361525 0.201994734820353 no 2658 0.210086074083042 874 1644229 SGTC_1000 4048-0884 8.67 µM -0.806344176357127 0.201933174528667 no 2659 0.210022212553581 886 13040088 SGTC_454 lyso-paf C-16 6.67 µM -0.807001659615016 0.201750553617357 no 2660 0.20983276349606 875 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2048 5246248 200 µM -0.807004261803721 0.201749831036463 no 2661 0.209832013893791 859 677046 SGTC_478 N-arachidonylglycine 10 µM -0.809840650869324 0.200963138771691 no 2662 0.209015882810704 836 5283389 SGTC_3180 9109287 49.47 µM -0.812109933124771 0.200335064713851 no 2663 0.208364276993225 859 18891271 SGTC_988 1497-1057 103 µM -0.812183749045495 0.200314654349092 no 2664 0.208343101497369 869 3533044 SGTC_1119 parthenolide 318.541 nM -0.814146272091755 0.199772468023068 no 2665 0.207780580232189 916 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2926 9010726 65.15 µM -0.814581265394059 0.199652412032757 no 2666 0.207656018937174 892 2994293 SGTC_2508 celastrol 40.54 µM -0.815920131600862 0.199283164150439 no 2667 0.207272908608735 826 122724 Celastrol is a natural product and antioxidant. SGTC_1762 st045503 25.4615 µM -0.816220437606823 0.199200398816726 no 2668 0.207187034868086 876 4645554 SGTC_411 enrofloxacin 100 µM -0.81651217400137 0.199120015125879 no 2669 0.207103631797262 857 71188 A bacterial gyrase inhibitor. SGTC_2183 6420625 130.508 µM -0.818169011788038 0.198663868482511 no 2670 0.206630343494085 881 2897619 SGTC_2097 5376186 200 µM -0.818228032424 0.198647631049561 no 2671 0.206613495624734 877 742755 SGTC_2671 danthron 100 µM -0.818285855744455 0.198631723791662 no 2672 0.206596990326807 880 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3344 9148862 3.898 µM -0.819313248333012 0.198349215085869 no 2673 0.206303857891857 889 4905352 SGTC_520 3584-0023 682 µM -0.821187026372157 0.197834595169116 no 2674 0.205769872603596 873 1340790 SGTC_2350 9023895 38.85 µM -0.822930689372171 0.197356435760519 no 2675 0.205273704695076 866 2997209 SGTC_1764 st044502 93.5 µM -0.82479311678312 0.196846480705584 no 2676 0.204744527584619 882 8407 SGTC_911 3456-4043 236 µM -0.826223378653551 0.19645539993729 no 2677 0.204338694343615 872 914281 SGTC_3287 9117173 37.0625 µM -0.827903639966899 0.195996563073468 no 2678 0.203862536687665 843 2789709 SGTC_2928 9011484 9.79 µM -0.828689287814231 0.195782245754864 no 2679 0.203640124446222 869 2994751 SGTC_3090 9117696 49.47 µM -0.829334118073522 0.195606448467785 no 2680 0.203457684988798 853 7923821 SGTC_3195 9113082 49.47 µM -0.82974766349442 0.195493755826231 no 2681 0.203340733435667 863 17018038 SGTC_1573 oleylamine 1.06 µM -0.830195398280311 0.195371790921814 no 2682 0.203214158291797 883 5356789 An amine of the fatty acid oleic acid. SGTC_2902 5787006 60.46 µM -0.830293215056303 0.195345151360008 no 2683 0.203186511636407 884 591003 SGTC_889 0919-1524 82.7 µM -0.831668359721029 0.19497087610041 no 2684 0.202798082355083 884 3905452 SGTC_2973 9094665 17.96 µM -0.832018574156897 0.19487562739857 no 2685 0.202699230202142 868 25237061 YIL048W NEO1 SGTC_1301 naphtanilide LB 4.81 µM -0.835253518719343 0.193997149950854 no 2686 0.201787491101939 872 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_871 0574-0004 149 µM -0.838347948599865 0.193159092482402 no 2687 0.200917656940187 893 9551173 SGTC_933 2914-0560 114 µM -0.838583545444329 0.193095376985527 no 2688 0.200851523724999 873 463887 SGTC_2825 7998094 58.44 µM -0.839465223830498 0.192857047200097 no 2689 0.200604148120846 883 2987815 SGTC_1252 0493-0875 34.8 µM -0.842346882830231 0.192079349395879 no 2690 0.199796907880912 874 3960963 SGTC_1191 1487-1166 10.6 µM -0.843130034590153 0.191868325653945 no 2691 0.199577861410657 918 3955771 SGTC_1679 SEC14.276 6.7 µM -0.843470852840507 0.19177653499169 no 2692 0.199482580165702 881 1005053 YMR079W SEC14 SGTC_1811 st050069 61.5 µM -0.846619002397634 0.190929933396011 no 2693 0.198603759372696 879 3877702 SGTC_3049 9092223 49.47 µM -0.847182616173152 0.190778608482984 no 2694 0.198446670738604 883 8623917 SGTC_2986 9022445 71.43 µM -0.850680051095256 0.189841226869183 no 2695 0.197473553838253 858 6459286 SGTC_1606 st000094 49.2 µM -0.850836897303974 0.189799255445461 no 2696 0.197429981075887 872 1242210 SGTC_386 1509-0011 3.07 µM -0.851366467018295 0.189657586852118 no 2697 0.197282906578416 877 3107280 SGTC_26 0302-0163 425.158 µM -0.853223728523878 0.189161253197776 no 2698 0.196767623542707 917 3100915 SGTC_2096 5468907 200 µM -0.854049143893192 0.188940926563708 no 2699 0.196538880196967 888 759785 SGTC_1246 0422-0085 105 µM -0.855782981306805 0.188478631599995 no 2700 0.19605891524466 892 264295 SGTC_1703 st026983 48.3 µM -0.856426651700734 0.188307186761637 no 2701 0.195880914004371 871 1104023 SGTC_3186 9110464 49.47 µM -0.856691481889246 0.188236675856718 no 2702 0.195807706087355 878 17018021 SGTC_2328 6201408 200 µM -0.857673444930884 0.187975370907844 no 2703 0.195536403640076 908 2890418 SGTC_3266 9136860 49.47 µM -0.859125754525419 0.187589315307278 no 2704 0.19513556983136 873 4871271 YPR165W RHO1 SGTC_3162 9099653 49.47 µM -0.860635319212951 0.187188559708959 no 2705 0.194719463523626 853 25237511 SGTC_139 0099-0334 718.624 µM -0.861044357117028 0.187080060546162 no 2706 0.194606806650485 906 97690 SGTC_2093 5331342 194.4 µM -0.861500670432934 0.186959067279983 no 2707 0.194481176036918 875 33839 SGTC_2749 bexarotene 57.39 µM -0.862685988233551 0.186645001908256 no 2708 0.194155069150098 899 82146 An retinoic acid receptor inhibitor. SGTC_1825 st052143 62.6 µM -0.862867101373065 0.186597042410417 no 2709 0.194105270309655 904 674173 SGTC_3153 9100258 49.47 µM -0.864924647223654 0.186052731768293 no 2710 0.193540074295806 902 25236848 SGTC_2994 9053520 71.4286 µM -0.867744889969381 0.185308255599264 no 2711 0.192767002704832 895 4647384 SGTC_2208 7283366 200 µM -0.869908893714244 0.184738266712695 no 2712 0.192175097375479 869 898663 SGTC_2828 7998861 71.43 µM -0.870249315649136 0.184648700417554 no 2713 0.192082085379429 840 2988188 SGTC_1117 retinoic acid 1.10837 µM -0.870548284668814 0.184570062813626 no 2714 0.192000422104859 899 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3224 9130643 49.47 µM -0.871009034090483 0.184448913016372 no 2715 0.191874610187899 886 17644395 SGTC_490 phenamil 164 µM -0.872153657824972 0.184148158944367 no 2716 0.191562278514734 878 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1132 3456-3614 2.5 µM -0.872544557090772 0.184045518694039 no 2717 0.191455685830924 915 3125502 SGTC_1451 4152-0210 104 µM -0.87279852905044 0.18397885117945 no 2718 0.191386450761279 905 659563 SGTC_120 rhodamine 6G 52.259 µM -0.875265021521667 0.183332180477682 no 2719 0.190714860782883 920 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2126 5251174 33.877 µM -0.875492483571974 0.183272615412349 no 2720 0.190652999104508 903 790722 SGTC_1219 1469-0211 33.1 µM -0.876899559985158 0.182904415210973 no 2721 0.190270597614252 908 6822282 SGTC_2957 9076800 11.52 µM -0.87802589149834 0.182610012547889 no 2722 0.189964834025019 924 16459615 SGTC_774 k060-0086 136 µM -0.878529872514331 0.182478376919256 no 2723 0.18982811689512 886 5911235 SGTC_2318 6029776 164 µM -0.878965573825611 0.182364623163227 no 2724 0.189709971074769 898 818325 SGTC_1903 st060211 78.3 µM -0.88078397565283 0.1818903497083 no 2725 0.189217377272735 877 688960 SGTC_2363 9053361 176 µM -0.880876320049497 0.181866285150186 no 2726 0.189192382777204 896 6469797 YMR079W SEC14 SGTC_1153 4055-0057 267 µM -0.882712632700437 0.181388163446481 no 2727 0.188695777483891 895 882706 SGTC_1642 st009582 77.7 µM -0.884750404161211 0.180858509940997 no 2728 0.188145631978173 903 6739311 SGTC_1277 0873-0036 22 µM -0.887366542318377 0.18017995124087 no 2729 0.187440795295589 905 5965735 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.887629015505598 0.18011196078799 no 2730 0.187370170291647 882 17037758 SGTC_3257 9139206 32.98 µM -0.888417730594902 0.179907750770483 no 2731 0.187158045687406 899 4910041 SGTC_2533 agelasine 13.65 µM -0.889357111012311 0.179664721080509 no 2732 0.186905593578464 857 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1556 plumbagin 1.48 µM -0.889904926073038 0.179523089614271 no 2733 0.186758469317972 873 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1736 st036774 51 µM -0.8909079441827 0.179263952414682 no 2734 0.186489279037592 909 1272247 SGTC_194 1486-1323 56.904 µM -0.890993360583398 0.179241895326053 no 2735 0.186466366069047 897 5178754 SGTC_1359 1582-0056 520 nM -0.891682973792845 0.179063878937574 no 2736 0.18628144104399 913 3661189 SGTC_2084 5306078 60.6385 µM -0.893113070875051 0.178695069095226 no 2737 0.185898311968198 923 679340 SGTC_445 e6 berbamine 66 µM -0.8934220851567 0.178615439830394 no 2738 0.18581558997735 896 6610268 A calcium/calmodulin antagonist. SGTC_986 1493-0483 84 µM -0.89355692371802 0.178580700558115 no 2739 0.18577950134436 898 40079 SGTC_16 erodoxin 22.806 µM -0.893846493830376 0.178506111244892 no 2740 0.185702014548491 885 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1022 4477-0945 21.3 µM -0.894126283924625 0.178434059774493 no 2741 0.185627163861203 875 4648966 SGTC_1066 ketoconazole 628 nM -0.894638485963299 0.178302205120508 no 2742 0.185490185811295 894 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_38 0929-0051 58.268 µM -0.89805551156968 0.177424142096342 no 2743 0.184577977709374 905 1379719 SGTC_1404 3909-7820 48.3 µM -0.89930041416047 0.177104922730333 no 2744 0.184246333419197 875 23741373 SGTC_2257 7960413 200 µM -0.904069087945069 0.17588549344912 no 2745 0.182979384190889 883 2974689 YIL048W NEO1 SGTC_2630 antimycin a 100 µM -0.904252560462942 0.175838682947331 no 2746 0.182930747755059 927 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2582 agaric acid 100 µM -0.906697923518622 0.175215535639442 no 2747 0.182283280905349 887 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1954 st077032 68.9 µM -0.907336221994934 0.175053110006451 no 2748 0.182114512484597 919 698907 SGTC_1678 st019265 80.2 µM -0.910442468031231 0.174264038325832 no 2749 0.181294604852657 899 5367020 SGTC_3039 9090270 49.47 µM -0.911382295477952 0.174025742440706 no 2750 0.181046989370439 867 17173750 SGTC_1158 4092-0494 91.8 µM -0.912577439584148 0.173723009679384 no 2751 0.180732412060203 908 1148199 SGTC_3012 9080433 71.4286 µM -0.913296745945654 0.173540969308784 no 2752 0.180543246661761 909 17688859 SGTC_2532 xanthone 78.9 µM -0.913770646446165 0.173421102039055 no 2753 0.180418686734529 907 7020 An insecticide. SGTC_744 1594-0068 283 µM -0.913850628892294 0.173400876667859 no 2754 0.18039766948066 907 668392 SGTC_3071 9117417 49.47 µM -0.917103668017436 0.172579544798321 no 2755 0.179544159578034 913 45595590 YGL055W OLE1 SGTC_670 4204-0025 119 µM -0.918408193059653 0.172250874488527 no 2756 0.179202601482656 915 719039 SGTC_3058 9093861 49.47 µM -0.919600702101771 0.171950775862873 no 2757 0.178890729848092 887 17217477 SGTC_956 1185-0240 191 µM -0.921052263753103 0.171585936587776 no 2758 0.178511570601492 909 1416193 SGTC_2187 6125751 200 µM -0.921053292273449 0.171585678252279 no 2759 0.178511302123526 912 874498 SGTC_1771 st048882 4.1505 µM -0.921727799186449 0.171416314534583 no 2760 0.178335288197031 914 4580403 SGTC_2311 7694451 200 µM -0.921938974760649 0.1713633118736 no 2761 0.178280203994891 906 2163142 SGTC_1875 nocodazole 6 µM -0.923514722969299 0.170968147825301 no 2762 0.177869515698351 898 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1284 0929-0043 16 µM -0.923698351378603 0.170922135691881 no 2763 0.177821695354629 915 1239883 SGTC_572 0960-0087 17.7 µM -0.924897438142685 0.170621872959282 no 2764 0.177509629675697 921 6796365 SGTC_1793 st048256 72.231 µM -0.926915403904598 0.170117317992002 no 2765 0.176985229374235 882 672022 SGTC_1718 roemerine 11.9335 µM -0.927735349964413 0.169912579135472 no 2766 0.176772433399217 863 235224 An aporphine alkaloid with mutagenic activity. SGTC_2628 lathosterol 100 µM -0.927766973184451 0.169904686047146 no 2767 0.176764229643859 913 6710616 SGTC_1160 4092-0570 10.5 µM -0.927903366106826 0.169870645357931 no 2768 0.176728849092554 915 4994975 SGTC_1973 st070275 50.2 µM -0.932168237572442 0.168808433334213 no 2769 0.175624793710418 886 17118334 SGTC_1888 azatryptophan 97.5 µM -0.93220603627877 0.16879903828148 no 2770 0.175615028267553 911 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_869 0564-0080 44.1 µM -0.932352829239049 0.168762555361701 no 2771 0.175577106997991 896 6843321 SGTC_2646 retinol 96.75 µM -0.934975094365423 0.168111689361206 no 2772 0.174900567380352 891 445354 A vitamin A analog and teratogen. SGTC_1221 2958-7315 257 µM -0.935066643612102 0.168088995364902 no 2773 0.174876977767149 918 4562705 SGTC_2860 9025725 38.96 µM -0.935607059731504 0.167955072644805 no 2774 0.17473776918679 927 40546248 SGTC_3060 1327-0027 12.5 µM -0.93798120106531 0.167367540892329 no 2775 0.17412703554614 893 16000455 YPR107C YTH1 SGTC_2910 7948405 25.97 µM -0.939095922576256 0.167092136837017 no 2776 0.173840748767386 870 2971328 SGTC_27 0485-0001 32.618 µM -0.943545365258917 0.16599576649877 no 2777 0.172701011300161 886 2054479 SGTC_2461 5755302 26.15 µM -0.944873672892747 0.165669366320314 no 2778 0.172361686891987 956 2788904 SGTC_558 k064-0027 21.3 µM -0.948987556149135 0.164661111817237 no 2779 0.171313470533792 887 5088526 SGTC_1834 st055981 52.8 µM -0.950408911714248 0.164313683777382 no 2780 0.170952258762893 907 471719 YDL150W RPC53 SGTC_3269 9137823 49.47 µM -0.951276378846008 0.164101878795162 no 2781 0.170732047313495 867 17682936 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.952340141552507 0.163842387186733 no 2782 0.17046225307061 898 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_669 0108-0021 26.2 µM -0.952670813232137 0.163761778251364 no 2783 0.170378442922208 915 17201 SGTC_2346 9031566 143.75 µM -0.953416676292554 0.163580051265884 no 2784 0.170189497671711 920 4771086 SGTC_3157 9099274 49.47 µM -0.953936201990973 0.163453548005131 no 2785 0.170057968539158 887 17217662 SGTC_2960 9079389 5.97 µM -0.954173587948625 0.163395766249443 no 2786 0.16999789085714 916 16457355 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.957491619266805 0.162589518313288 no 2787 0.169159587233962 921 4213774 SGTC_737 1950-0117 57.9 µM -0.959205756211148 0.162174016138555 no 2788 0.168727550616781 920 5393513 SGTC_2664 lyso-paf C-16 73.48 µM -0.960444996064806 0.161874058731481 no 2789 0.168415650644482 919 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2292 7671323 168.05 µM -0.960695263386447 0.161813525546468 no 2790 0.16835270675964 930 937504 SGTC_3160 9100216 49.47 µM -0.963638992968779 0.161102620861956 no 2791 0.167613475158021 903 17191039 SGTC_535 2293-4129 48.2 µM -0.963884459648685 0.161043433355519 no 2792 0.167551927958724 948 396118 YIL048W NEO1 SGTC_592 k241-0073 46.5 µM -0.967675986678065 0.160131014110696 no 2793 0.166603107269356 916 4230158 SGTC_1103 duloxetine 36.1 µM -0.968020926319634 0.160048173503613 no 2794 0.166516959368299 938 60835 A selective serotonin reuptake inhibitor. SGTC_273 hydroxyurea 18.1 mM -0.96969718270115 0.159646003292031 no 2795 0.166098727592057 943 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2041 5107442 45.335 µM -0.970418879630741 0.159473056401326 no 2796 0.165918870885484 912 793005 SGTC_2518 prenyletin 46.28 µM -0.971601558433878 0.159189905452771 no 2797 0.165624403468839 905 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1138 3761-0006 1.03 µM -0.973772976076165 0.158670893516144 no 2798 0.165084636924447 925 12061087 SGTC_1334 1486-0610 236 µM -0.975310952599778 0.158303958542822 no 2799 0.164703019604048 895 3742339 SGTC_2089 5281248 129.67 µM -0.977533724159512 0.157774627743729 no 2800 0.164152495185458 919 2737878 SGTC_1278 0874-0585 172 µM -0.977680075482677 0.157739816479421 no 2801 0.164116289582103 929 766306 SGTC_3190 9110366 49.47 µM -0.977786804358502 0.15771443302939 no 2802 0.164089889374471 921 17123768 SGTC_2281 7943571 200 µM -0.979135543054196 0.157393892182604 no 2803 0.163756505879283 928 1244024 SGTC_1223 0764-0573 147 µM -0.980245413670864 0.157130442049309 no 2804 0.163482496188389 911 1609797 SGTC_1365 1672-3266 55.4 µM -0.982344323703319 0.156633016738849 no 2805 0.162965122659247 902 6415873 SGTC_270 tamoxifen 5.46 µM -0.983095862704081 0.156455160161443 no 2806 0.162780130178385 947 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1722 st034304 3.6505 µM -0.983830731798992 0.156281377272744 no 2807 0.162599373136646 943 4036148 YLR033W RSC58 SGTC_2076 5212012 200 µM -0.985718004721801 0.155835655107959 no 2808 0.162135755871516 918 604802 SGTC_1772 st048439 82.2 µM -0.987241765799585 0.155476396598785 no 2809 0.16176206566362 913 2927068 YDL195W SEC31 SGTC_1434 4073-0095 163 µM -0.987437522515832 0.155430282503825 no 2810 0.161714098613234 908 24133745 SGTC_189 3970-0742 2.116 µM -0.989067656509398 0.155046624972122 no 2811 0.161315020420708 914 2891807 SGTC_3327 9140648 26.9345 µM -0.990242530777329 0.154770502429687 no 2812 0.161027794444853 928 8029710 SGTC_2196 6573537 42.6665 µM -0.992217542225581 0.154307061749479 no 2813 0.160545708481561 945 2903087 SGTC_449 xestospongin c 11.1929 µM -0.992620666419344 0.154212580674682 no 2814 0.160447424769719 920 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2359 9039622 200 µM -0.994788170318839 0.153705234215359 no 2815 0.159919650466381 935 6463596 SGTC_532 1548-0774 215 µM -0.995406436740846 0.153560719714504 no 2816 0.159769314643178 955 5932993 SGTC_2499 avocadenofuran 51.48 µM -0.99697872682948 0.153193615806921 no 2817 0.159387417953282 941 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_934 2950-0684 338 µM -1.00050989329512 0.152371267898387 no 2818 0.158531906136533 935 1121253 SGTC_450 aminopyrene 156 nM -1.0015900668455 0.152120300377657 no 2819 0.158270810193502 921 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_459 nigericin 15.3 µM -1.0067483513552 0.150925611743966 no 2820 0.157027860126129 945 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2814 7977482 42.97 µM -1.01010603719666 0.150151316749919 no 2821 0.156222245054603 935 6456762 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.01158376512245 0.149811387720932 no 2822 0.155868555783102 915 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_559 1550-0661 158 µM -1.01310730630663 0.149461457881855 no 2823 0.155504454398483 930 5830875 SGTC_23 0213-0011 39.996 µM -1.02614470789804 0.146489322477179 no 2824 0.152411689677814 945 627608 SGTC_786 4544-0069 423 µM -1.02789329503298 0.146093735582179 no 2825 0.152000011942079 923 748821 YLR208W SEC13 SGTC_1058 3448-5425 97.3 µM -1.02939524325271 0.145754519817259 no 2826 0.151646991729915 922 7279705 SGTC_857 0438-0306 1.35 µM -1.03302310624954 0.144937350500852 no 2827 0.150796542795401 920 4686136 SGTC_1603 st002045 67.8 µM -1.03437592589451 0.144633421464461 no 2828 0.150480227196322 950 5887985 SGTC_2551 apiole 73.87 µM -1.03488773683269 0.144518548305619 no 2829 0.150360671152211 916 10659 A possible DNA adduct former. SGTC_501 nsc-95397 161 µM -1.03946010485282 0.143495033323747 no 2830 0.149295401567024 936 262093 SGTC_2716 st080858 38.6235 µM -1.04264741610776 0.142784461726006 no 2831 0.148555810064814 925 5296050 SGTC_1456 k015-0012 13 µM -1.04390523849277 0.142504701439459 no 2832 0.148264617156131 940 2989616 SGTC_2077 5212015 200 µM -1.04404481608515 0.142473679965687 no 2833 0.1482323277174 928 780900 SGTC_2531 methyl deoxycholate 70.07 µM -1.04463453621676 0.142342663590209 no 2834 0.148095955660953 969 16667744 Haematoxylin. SGTC_465 cgp-37157 41 µM -1.04760173459285 0.141684686973443 no 2835 0.147411068974262 909 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3177 9107506 49.47 µM -1.04888554577495 0.141400641221394 no 2836 0.147115399399894 939 8897194 SGTC_2932 9016711 44.54 µM -1.04928683800479 0.141311933751527 no 2837 0.147023060965412 952 7117328 SGTC_2431 5490079 200 µM -1.05020688388772 0.141108695844392 no 2838 0.146811502630444 962 5722345 SGTC_1851 st056236 18.9 µM -1.05056769959069 0.141029045880544 no 2839 0.146728591273711 894 5393171 SGTC_2382 9035899 200 µM -1.0543732785734 0.140190822213227 no 2840 0.145856025628804 954 6462679 SGTC_3034 9090421 49.47 µM -1.05561393973311 0.139918284935619 no 2841 0.145572314824064 926 17173761 SGTC_666 0272-0154 136 µM -1.05793683885092 0.139408980140028 no 2842 0.145042119388127 954 6870312 SGTC_2000 st075254 36.4 µM -1.05816777962768 0.139358414474647 no 2843 0.144989478907233 922 17234175 SGTC_987 1497-1013 404 µM -1.05822482464627 0.139345926097783 no 2844 0.144976478086147 953 1676435 SGTC_366 0181-0206 4.31 µM -1.05914385116944 0.139144836441439 no 2845 0.144767135895227 964 274874 SGTC_2400 5203494 178.7 µM -1.06392958121695 0.138100876983431 no 2846 0.143680300603374 935 6777674 SGTC_1003 4049-0218 100 µM -1.06651733463274 0.137538614780905 no 2847 0.14309492343721 939 295161 SGTC_257 daunorubicin 18.5 µM -1.06994766976189 0.13679568976834 no 2848 0.142321432125671 916 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_435 c-PAF 6.7 µM -1.07121719732212 0.13652143852716 no 2849 0.142035890386966 928 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2192 5915882 198.485 µM -1.07279524221492 0.136181064000868 no 2850 0.141681497990141 936 2876149 SGTC_1673 st016611 27.3 µM -1.0754794897496 0.135603423493863 no 2851 0.141080055035549 975 5226799 SGTC_2620 irigenin 100 µM -1.07617896225366 0.135453175608884 no 2852 0.140923613292219 924 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1654 st012436 41.8 µM -1.07642522845822 0.135400304372419 no 2853 0.140868562213944 963 4323132 SGTC_2667 digitoxin 100 µM -1.07723136995493 0.135227331662153 no 2854 0.140688457007669 907 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2469 5655019 90.81 µM -1.07782399942697 0.135100268603677 no 2855 0.140556153592995 952 2788239 SGTC_39 0986-0283 58.349 µM -1.07869250726738 0.13491420363854 no 2856 0.140362413476631 909 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2827 7993847 71.43 µM -1.08038673752013 0.13455174596111 no 2857 0.139984999609198 924 2985692 SGTC_3262 9137218 49.47 µM -1.08136396033588 0.134342986572951 no 2858 0.139767623211894 917 17650664 SGTC_2078 5212016 200 µM -1.08180419034475 0.13424901506842 no 2859 0.139669772130052 947 1899708 SGTC_1215 3852-0577 11.2 µM -1.08470347076517 0.133631262404021 no 2860 0.139026505083723 937 2884876 SGTC_3308 9128332 17.569 µM -1.08640503213148 0.133269620536738 no 2861 0.138649918108217 934 17332805 YDL196W YDL196W SGTC_3292 9120825 59.784 µM -1.08870900021937 0.132781020042405 no 2862 0.138141115801078 930 24824900 SGTC_1422 4031-0024 15.5 µM -1.08877368145426 0.132767320975497 no 2863 0.138126850162629 960 782427 SGTC_379 3970-0972 5.9 µM -1.08898655253021 0.132722243132541 no 2864 0.138079907908171 961 2898042 YBL034C STU1 SGTC_2479 5617353 43.85 µM -1.08915627094037 0.132686310904986 no 2865 0.138042489459981 932 2731746 SGTC_1687 st020778 55.3625 µM -1.09015286229969 0.132475451034397 no 2866 0.13782290679819 953 4259299 SGTC_606 k015-0008 38.6 µM -1.0907069811821 0.132358309900933 no 2867 0.137700918879216 985 1970475 SGTC_2536 dehydroabietamide 32.04 µM -1.09530403142838 0.131389242956382 no 2868 0.136691730960272 952 3983547 SGTC_1987 st072290 61.9 µM -1.09540089429038 0.13136887691504 no 2869 0.136670521249284 962 54697379 SGTC_2335 9018011 154.17 µM -1.09754649994577 0.130918308320654 no 2870 0.136201282654632 945 6458208 SGTC_1579 chlormadinone acetate 49.4 µM -1.09866153446767 0.130684577704392 no 2871 0.135957863248706 968 45114258 A steroidal progestin. SGTC_232 clozapine 119 µM -1.09873072605809 0.130670083456416 no 2872 0.135942768088096 951 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3322 9139058 2.11 µM -1.1003322243631 0.13033491227634 no 2873 0.13559369837009 951 4908926 YPR165W RHO1 SGTC_2744 captopril 92.04 µM -1.10051046738126 0.130297645320175 no 2874 0.135554885737047 948 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2233 sulbentine 40.3845 µM -1.10073355297214 0.130251013090608 no 2875 0.135506319305855 923 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_739 1486-1183 203 µM -1.10077699470571 0.130241933682126 no 2876 0.135496863291654 946 4346692 SGTC_1750 st081859 2.357 µM -1.1022158823607 0.129941450743004 no 2877 0.135183914392602 937 5291695 SGTC_938 3126-1755 342 µM -1.10464702929338 0.129434845421106 no 2878 0.134656282195137 936 1777771 SGTC_2415 st077333 57.7 µM -1.10497157064822 0.129367320787181 no 2879 0.134585954010151 923 2766255 SGTC_2736 butenafine 14.65 µM -1.10539996064061 0.129278226611503 no 2880 0.134493160411436 949 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_945 3381-0768 11.3 µM -1.11125317456448 0.128065166878413 no 2881 0.133229694331121 958 1126236 YIL048W NEO1 SGTC_2953 9074162 66.49 µM -1.11206986503808 0.127896541063071 no 2882 0.133054056170739 912 16451992 SGTC_2412 st077135 33.4 µM -1.11547851048983 0.127194408516931 no 2883 0.132322711118774 978 13258915 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.11590224196243 0.12710731362606 no 2884 0.132231991022963 967 94937 An inhibitor of serotonin biosynthesis. SGTC_793 0488-0545 106 µM -1.11768389860423 0.126741561318269 no 2885 0.131851010967201 961 292548 SGTC_1280 0880-0253 10.1 µM -1.11831644386062 0.126611883967915 no 2886 0.131715933148232 952 6836607 SGTC_2491 paeonol 100 µM -1.12416153771003 0.125417959928597 no 2887 0.130472251506175 980 11092 Increases levels of cortical cytochrome oxidase. SGTC_41 0478-0632 82.643 µM -1.12424206526216 0.125401566363244 no 2888 0.130455174275956 938 3750424 SGTC_321 4534-3890 65.3 µM -1.12459231159818 0.125330281631207 no 2889 0.130380916597534 958 699746 SGTC_791 1348-1292 225 µM -1.12577922844776 0.125088921896357 no 2890 0.130129489188668 976 5437054 SGTC_635 k038-0028 24.7 µM -1.12612420260284 0.125018832273423 no 2891 0.130056475471004 973 4035102 SGTC_140 0062-0056 502.533 µM -1.12721977621224 0.124796422609842 no 2892 0.129824785546894 965 3758964 SGTC_1530 rhein 70.4 µM -1.12910764780577 0.124413819520549 no 2893 0.129426212749831 952 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_742 0kpi-0133 140 µM -1.12943261490368 0.124348043313407 no 2894 0.129357690405052 969 2728852 SGTC_3277 9138724 49.47 µM -1.13112795713533 0.124005285496002 no 2895 0.129000619404337 958 15943418 SGTC_595 3909-8003 73.7 µM -1.13226526085571 0.123775720629801 no 2896 0.128761465222328 976 699517 SGTC_1194 1488-0194 225 µM -1.13284498517699 0.123658817769183 no 2897 0.128639678224447 952 1391452 SGTC_798 1287-0182 476 µM -1.13541091860101 0.123142319352663 no 2898 0.128101593494106 983 1649755 SGTC_3337 9144342 33.5465 µM -1.13572074151347 0.123080057351899 no 2899 0.1280367285403 948 17682949 SGTC_1201 1889-3372 45.9 µM -1.13993405099607 0.122235540777363 no 2900 0.127156888770478 958 5392199 SGTC_3283 9109332 35.8195 µM -1.14007123190549 0.122208112758103 no 2901 0.127128313004442 926 17027281 SGTC_440 fluspirilene 35.1 µM -1.14196646087789 0.121829621886175 no 2902 0.126733980509958 981 3396 An atypical antipsychotic. SGTC_2003 4023581 200 µM -1.14316264673456 0.121591159296253 no 2903 0.126485533911677 955 16641307 SGTC_1615 st002656 86.5 µM -1.14376326512747 0.121471548335877 no 2904 0.126360914113834 975 1584458 SGTC_2324 6149169 200 µM -1.14709821976083 0.120808909040974 no 2905 0.125670514780886 966 2888231 SGTC_1424 4048-1941 275 µM -1.14723601839698 0.120781583961476 no 2906 0.125642044558039 956 X1424 SGTC_2358 9037157 4 µM -1.14800520761669 0.120629135831014 no 2907 0.125483207015064 946 2388925 SGTC_3150 9097574 49.47 µM -1.14917231819382 0.12039808117385 no 2908 0.12524246646619 947 17217476 SGTC_1251 0490-5699 265 µM -1.14984138204983 0.120265766240444 no 2909 0.125104603805244 966 3883818 SGTC_3265 9137266 49.47 µM -1.15273448106618 0.119694802574058 no 2910 0.124509692004686 931 17224265 SGTC_1976 st070609 63.5 µM -1.15357987243037 0.119528323000032 no 2911 0.124336227080567 946 682556 SGTC_3047 9092122 49.47 µM -1.15527384116548 0.119195228181083 no 2912 0.123989152307347 971 17173831 SGTC_1698 5-fluorocytosine 1.055 µM -1.15557094230887 0.119136875075977 no 2913 0.1239283496407 957 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2476 5806916 10.51 µM -1.15642545448295 0.118969154289868 no 2914 0.123753587420348 937 2870194 SGTC_1531 st059297 52.4 µM -1.15707506807278 0.118841761917644 no 2915 0.123620845924297 953 7566702 SGTC_1188 1403-0014 4.57 µM -1.15821431361503 0.118618583058585 no 2916 0.123388294265824 944 9614867 SGTC_2920 7982904 15.77 µM -1.15838971016092 0.118584249098443 no 2917 0.12335251820138 976 6456808 SGTC_813 k007-0158 173 µM -1.15952730342084 0.11836173513316 no 2918 0.123120656933558 969 6523916 SGTC_2641 levomentholum 100 µM -1.15974307927558 0.118319562562761 no 2919 0.123076712553781 962 16666 SGTC_3202 9113761 49.47 µM -1.16236852101191 0.117807280807529 no 2920 0.122542902152246 969 4798415 SGTC_3128 9127691 49.47 µM -1.16310180311837 0.117664482062121 no 2921 0.122394100319444 964 41316314 SGTC_3133 9127736 49.47 µM -1.16326921519397 0.117631897559802 no 2922 0.12236014588391 940 27243420 SGTC_593 1203-0218 61.7 µM -1.16401608685262 0.117486606877685 no 2923 0.122208746279711 975 3666956 SGTC_3069 9117009 49.47 µM -1.16668836110787 0.116967803881409 no 2924 0.121668122381233 957 41904981 SGTC_2763 lisinopril 49.32 µM -1.16922210945051 0.116477396165449 no 2925 0.121157077768047 958 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2921 7974240 10.71 µM -1.17175621208287 0.11598838038289 no 2926 0.12064747374933 965 2979074 YDR527W RBA50 SGTC_205 1486-1330 71.903 µM -1.17228203389281 0.115887093334487 no 2927 0.120541921144803 976 4118834 SGTC_3073 9114972 49.47 µM -1.17300380330246 0.115748163941388 no 2928 0.120397140257377 952 41905075 SGTC_2252 omeprazole 400 µM -1.17471878971001 0.115418530280662 no 2929 0.120053619762294 960 4594 A proton pump inhibitor. SGTC_2745 rifampicin 24.3 µM -1.17492081627651 0.11537974317751 no 2930 0.120013198340422 935 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.17740458297043 0.11490364143945 no 2931 0.119517030760482 988 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_672 1441-0018 53.7 µM -1.17939983124994 0.114522194964862 no 2932 0.119119501150094 950 251141 SGTC_3155 9099265 49.47 µM -1.17943025658347 0.114516385312484 no 2933 0.119113446496624 976 25236499 SGTC_1841 st054148 70 µM -1.17967555517777 0.114469553733916 no 2934 0.11906463991566 992 675442 SGTC_1383 3049-0032 20.7 µM -1.18643927278683 0.113183614517912 no 2935 0.117724435049846 967 712864 SGTC_1332 1480-0653 17.5 µM -1.18659842803487 0.113153480046528 no 2936 0.117693028134437 975 5749438 SGTC_1983 st071813 46.9 µM -1.18962148586212 0.112582180703222 no 2937 0.117097598563913 980 11838595 SGTC_1506 4226-2149 212 µM -1.19250514693322 0.112039147322839 no 2938 0.116531616906046 970 991114 SGTC_846 0335-0850 148 µM -1.19349825024966 0.111852566398082 no 2939 0.116337148510098 958 6819598 SGTC_3270 9137563 49.47 µM -1.19351207420278 0.111849970769146 no 2940 0.116334443144657 931 17015724 SGTC_2523 spermine 47.74 µM -1.19684222344774 0.11122594603731 no 2941 0.115684028641694 952 1103 A DNA binding polyamine. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.19775080575367 0.111056123692447 no 2942 0.115507021958698 920 4000243 SGTC_778 3456-2434 196 µM -1.19785874020493 0.111035962102849 no 2943 0.115486007358575 881 5539063 SGTC_2918 7977171 22.06 µM -1.20188009291461 0.110286661890884 no 2944 0.114704994140214 956 2236483 SGTC_2248 tofa 1.1 µM -1.20218440858427 0.110230106581822 no 2945 0.114646044339152 937 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1809 st050081 57.6 µM -1.21191519023854 0.108432651082039 no 2946 0.112772423403217 981 5036894 SGTC_1375 2910-0797 186 µM -1.21207425031625 0.108403445958651 no 2947 0.112741979740718 983 742508 SGTC_973 1325-0077 65.9 µM -1.21237290134061 0.108348625742729 no 2948 0.11268483460806 984 2835149 SGTC_1449 4112-4002 201 µM -1.21496277226268 0.107874066951393 no 2949 0.112190145200404 980 2059539 SGTC_946 3434-1334 87.4 µM -1.21740607128203 0.107427739489584 no 2950 0.111724877111711 960 4047976 SGTC_3164 9100705 49.47 µM -1.21771070198289 0.10737218480831 no 2951 0.111666964366647 945 17174235 SGTC_2740 felodipine 17.08 µM -1.22023971031686 0.106911775849319 no 2952 0.111187008640858 970 3333 L-type calcium channel blocker SGTC_1755 st041960 45.185 µM -1.22088468987372 0.106794584828827 no 2953 0.111064841018603 982 2257073 SGTC_2738 aclarubicin 5.55 µM -1.22438842290562 0.106159585413571 no 2954 0.110402867266986 983 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2642 cholecalciferol 100 µM -1.22615473342052 0.10584050401101 no 2955 0.110070226041892 964 9821465 A vitamin D precursor, similar to steriods. SGTC_2976 9009005 19.48 µM -1.22675901990887 0.105731499849682 no 2956 0.109956588759417 956 2993148 SGTC_784 4579-0127 173 µM -1.22799601533097 0.105508617703251 no 2957 0.109724231898079 977 1948547 SGTC_2466 5983409 37.09 µM -1.22853650350628 0.105411339150737 no 2958 0.109622817484124 1002 2879657 SGTC_470 aa-861 153 µM -1.23204955228379 0.10478063191232 no 2959 0.108965287214333 964 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_565 1418-0001 44.5 µM -1.23216452326929 0.104760037137293 no 2960 0.108943816338866 986 2862145 SGTC_2829 7992743 58.44 µM -1.23246514776978 0.104706200065909 no 2961 0.108887688971742 981 16462845 SGTC_718 1130-0073 349 µM -1.23653142957921 0.103979961286851 no 2962 0.108130545232159 986 6740020 SGTC_3306 9127676 59.7925 µM -1.23908064885422 0.103526536988519 no 2963 0.107657816300926 972 41905287 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.24343354873062 0.102755615933029 no 2964 0.10685405700493 965 756377 SGTC_1984 st072354 53.1 µM -1.24415839618137 0.102627647959674 no 2965 0.106720636145582 965 5762938 SGTC_579 4491-1009 110 µM -1.24467603860594 0.102536331863799 no 2966 0.106625428612158 1006 1271041 SGTC_3042 9091578 49.47 µM -1.25009477234647 0.101583969408126 no 2967 0.105632464609761 961 25236497 SGTC_3144 9087057 49.47 µM -1.25142804472216 0.10135063245977 no 2968 0.105389175353548 975 17249618 SGTC_1090 efavirenz 20.7 µM -1.25327267148708 0.101028447176901 no 2969 0.105053245261737 973 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1265 0819-1001 68.8 µM -1.254138120753 0.100877544072077 no 2970 0.104895903285491 976 3106768 SGTC_2919 7978188 46.38 µM -1.25519478038412 0.100693523683861 no 2971 0.104704029946351 953 2980291 SGTC_2794 7785382 27.27 µM -1.25592240737381 0.100566947724125 no 2972 0.104572051802993 967 2205081 SGTC_610 4215-0184 155 µM -1.25618123258771 0.100521951211941 no 2973 0.104525134742838 938 5605015 SGTC_1620 st003704 16.5 µM -1.25760117917048 0.100275356189149 no 2974 0.104268013355949 986 2834414 SGTC_1343 1487-0095 224 µM -1.25929159254819 0.0999823666001174 no 2975 0.103962514429828 989 4560101 YGL055W OLE1 SGTC_1177 0983-0204 23.6 µM -1.26066036134637 0.0997455842373652 no 2976 0.10371562052513 967 766818 SGTC_3021 9087658 49.47 µM -1.26204591990544 0.0995063149268956 no 2977 0.103466131663742 971 25237042 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.26358569886613 0.0992409060340082 no 2978 0.103189384646308 976 688788 SGTC_384 k007-0144 5.16 µM -1.26369295168343 0.0992224383632407 no 2979 0.103170127964242 993 6824886 SGTC_2820 7989630 71.43 µM -1.26509665384206 0.0989809690286181 no 2980 0.102918341130504 960 2984098 SGTC_2978 9011784 42.97 µM -1.26522802831587 0.0989583915900119 no 2981 0.10289479891023 960 2994934 SGTC_1340 1486-1359 257 µM -1.26718039281784 0.0986233107355714 no 2982 0.10254539747923 966 4309068 SGTC_919 tnp00227 403.569 nM -1.27088973784231 0.0979889717849421 no 2983 0.101883938867038 994 1269246 A methoxyflavone. YNL221C POP1 SGTC_2751 anetholtrithion 17.25 µM -1.27290625628176 0.0976453818951327 no 2984 0.101525654471294 995 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2746 daunorubicin 9.88 µM -1.27472084380148 0.0973369544070909 no 2985 0.101204033246993 966 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_507 nimesulide 162 µM -1.27509492529113 0.0972734603095654 no 2986 0.101137822679908 994 4495 A COX2 inhibitor. SGTC_506 n9-isopropylolomoucine 153 µM -1.27912552754808 0.0965912595851588 no 2987 0.100426427761855 984 6610355 SGTC_1872 amphotericin b 148 nM -1.27926148171398 0.0965683100548682 no 2988 0.100402495886442 974 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2742 clothiapine 36.27 µM -1.28238871926572 0.0960415268681924 no 2989 0.0998531597188261 987 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2638 epoxomicin 18 µM -1.28259020164203 0.0960076597558953 no 2990 0.0998178423889485 975 9915668 A protesome inhibitor. SGTC_3084 9116877 49.47 µM -1.28379932729027 0.0958046026570308 no 2991 0.099606089521093 974 27241325 SGTC_2430 5571206 200 µM -1.28387014455038 0.0957927196099716 no 2992 0.0995936975544638 984 1731771 SGTC_3118 9124250 49.47 µM -1.28402759891678 0.0957663028509169 no 2993 0.0995661494206811 964 1504786 SGTC_3297 9117502 71.43 µM -1.28535150730695 0.095544397302876 no 2994 0.0993347393272584 986 7453720 SGTC_2741 miltefosine 3.04 µM -1.28640974165768 0.0953672947410401 no 2995 0.099150050185215 963 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2452 5863136 48.41 µM -1.28783511952182 0.095129130409316 no 2996 0.0989016821467654 981 2184096 SGTC_2639 lactacystin 53 µM -1.29030271338043 0.0947178597546231 no 2997 0.098472787586901 958 3870 A proteasome inhibitor. SGTC_1845 st056753 3.01 µM -1.29172285137442 0.0944817620913986 no 2998 0.0982265704429841 984 5375839 SGTC_1382 3002-2117 298 µM -1.29417299912655 0.0940754460796525 no 2999 0.0978028355213821 1021 1497314 SGTC_539 4859-0462 2.54 µM -1.29650702774335 0.0936895868952066 no 3000 0.0974004302095501 964 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1216 1165-0504 9.65 µM -1.29756948664928 0.093514329812718 no 3001 0.0972176565413041 1009 6304004 SGTC_2708 st078559 56 µM -1.29782577823283 0.0934720897045917 no 3002 0.0971736046762654 962 17250902 SGTC_2970 9090938 41.86 µM -1.2990257525381 0.0932745061413585 no 3003 0.096967545746004 983 17217104 SGTC_2010 4012422 159 µM -1.30078138636387 0.0929859858908548 no 3004 0.0966666475057246 982 952393 SGTC_1354 1498-1681 81 µM -1.30183817970679 0.0928126312216456 no 3005 0.0964858545695702 1002 5754243 SGTC_2215 7188065 200 µM -1.30213901921064 0.0927633257224393 no 3006 0.0964344333342534 1000 940217 SGTC_552 k242-0005 476 µM -1.30325093269336 0.0925812589443067 no 3007 0.0962445533765383 1005 4088318 SGTC_2644 guaiazulene 100 µM -1.30354516353521 0.0925331252989374 no 3008 0.0961943539868502 973 3515 A coloring agent. SGTC_763 3453-1109 128 µM -1.30418639005154 0.0924282902769439 no 3009 0.0960850195655096 986 1560353 SGTC_556 4058-0063 51.5 µM -1.30772236415871 0.091851767052419 no 3010 0.0954837475013463 1003 6615692 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.30784610267779 0.0918316404389689 no 3011 0.0954627567424407 1006 368090 SGTC_2262 9014885 67.46 µM -1.308700328766 0.0916927859240734 no 3012 0.0953179401613078 1008 6457424 SGTC_2289 7946404 165.07 µM -1.31122536602812 0.0912832504769859 no 3013 0.0948908174187988 972 1246120 YPR165W RHO1 SGTC_2915 7971052 15.16 µM -1.31405247722183 0.090826332688303 no 3014 0.0944142725280588 957 5741558 SGTC_1176 0848-0131 83.3 µM -1.31493237959787 0.0906844697066383 no 3015 0.0942663147006674 995 6769040 SGTC_2851 9015922 71.43 µM -1.31733539717954 0.0902978791537182 no 3016 0.0938631125748345 974 2996893 SGTC_2172 5754775 163.918 µM -1.31916257314918 0.0900047485009982 no 3017 0.0935573838330996 969 2263357 SGTC_3040 9091894 49.47 µM -1.32182135261271 0.0895794690445657 no 3018 0.0931138231491637 975 25236966 SGTC_512 prima-1 270 µM -1.32391295667278 0.0892459624598615 no 3019 0.0927659773093703 1000 322968 A re-activator of the apoptotic function of mutant p53. SGTC_202 3594-0513 34.79 µM -1.32526222605051 0.0890313119991042 no 3020 0.0925420964788491 1007 708429 SGTC_1748 st037455 53.6035 µM -1.32557965803645 0.0889808687571329 no 3021 0.0924894839274492 1011 580690 SGTC_581 0958-0271 211 µM -1.32697737217275 0.0887590105115228 no 3022 0.0922580839771039 993 4591145 SGTC_359 0081-0058 15.9 µM -1.32860545908316 0.0885011050198178 no 3023 0.0919890850316703 996 3494159 SGTC_345 1362-0200 395 µM -1.32910972848648 0.0884213369796849 no 3024 0.0919058855699354 1015 1419823 SGTC_2879 9041815 71.43 µM -1.33016486617168 0.0882546029779354 no 3025 0.0917319786217031 994 4942971 SGTC_546 peri-Naphthalide 147 µM -1.33056953727793 0.088190718619933 no 3026 0.0916653457729687 985 223824 A penicillin ester. SGTC_2050 5263056 171 µM -1.33061300733664 0.08818385816749 no 3027 0.0916581901584542 992 763468 YGL055W OLE1 SGTC_2891 9063876 19.48 µM -1.33074804393951 0.0881625492040108 no 3028 0.0916359643976919 990 6472478 SGTC_274 sirtinol 40.1 µM -1.33088638357928 0.0881407229973748 no 3029 0.0916131991293011 992 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2226 7298446 200 µM -1.33123378048914 0.0880859310377038 no 3030 0.0915560497254763 1007 3283010 SGTC_746 1095-0025 46.6 µM -1.33247076453383 0.0878910382548029 no 3031 0.0913527710644494 985 6749286 SGTC_154 3389-1638 511.116 µM -1.33468144258011 0.0875435365329217 no 3032 0.0909903148899538 1016 5238686 SGTC_2063 5246145 200 µM -1.33615596039108 0.0873123242530268 no 3033 0.090749151109135 999 711240 SGTC_1435 4092-0789 56.7 µM -1.33660188409517 0.0872424908918589 no 3034 0.0906763118537846 992 2248285 SGTC_2997 9067075 71.4286 µM -1.33744240651039 0.087110975258018 no 3035 0.0905391349991766 980 27209819 SGTC_1401 3807-4679 7.6 µM -1.34001094069918 0.086709997062647 no 3036 0.0901208940115298 987 3291456 SGTC_1291 0993-0025 5.79 µM -1.34009919770537 0.0866962436664937 no 3037 0.0901065484476705 988 4353356 SGTC_2692 st077426 47.7 µM -1.34073885625254 0.0865966121749892 no 3038 0.0900026270927517 1014 25238571 SGTC_2237 6667747 47.222 µM -1.34125042203315 0.0865169936795152 no 3039 0.0899195802893835 1018 729940 YDL015C TSC13 SGTC_468 gf-109203x 121 µM -1.34395982996717 0.0860962221752389 no 3040 0.0894806885103947 1028 2396 A protein kinase C inhibitor. SGTC_1882 5615643 20 µM -1.34478896982475 0.0859677630562222 no 3041 0.0893466966474723 949 2253075 SGTC_1345 1488-0192 31.4 µM -1.34496589155446 0.0859403710464292 no 3042 0.0893181248180889 1003 658348 SGTC_2543 pimpinellin 60.67 µM -1.34898229855263 0.0853202843828393 no 3043 0.0886713259302759 994 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.35090417697625 0.085024756952272 no 3044 0.0883630650146091 1013 5393153 SGTC_3132 9126706 49.47 µM -1.35200860388094 0.0848552766152984 no 3045 0.0881862814541052 994 850858 SGTC_577 r071-0003 38.6 µM -1.35923082625954 0.0837532258695544 no 3046 0.0870367279660933 1029 4568517 YMR134W ERG29 SGTC_2909 7941780 10.49 µM -1.36075394858557 0.0835221890916556 no 3047 0.0867957297404966 972 1243215 SGTC_3183 9108214 49.47 µM -1.3611176469366 0.0834670919393267 no 3048 0.0867382568615068 1001 4974831 SGTC_280 3448-3607 3.04 µM -1.36129218490226 0.0834406606500463 no 3049 0.0867106858657304 979 626179 SGTC_3251 9135047 49.47 µM -1.36204741620792 0.0833263641221346 no 3050 0.0865914607742276 1008 17682963 SGTC_2212 7123476 200 µM -1.36284808041046 0.0832053203599893 no 3051 0.0864651972490412 998 1085715 SGTC_1270 0831-1170 17.3 µM -1.36678841483539 0.082611549521596 no 3052 0.0858458175582343 995 6764716 SGTC_1616 st002734 56.1 µM -1.37117019257997 0.0819550088845506 no 3053 0.0851609538873345 1000 4026101 SGTC_1145 3546-0597 10.2 µM -1.38123481956779 0.0804618799371336 no 3054 0.0836033859830256 1008 875334 SGTC_2435 5706476 10.6 µM -1.38143648496853 0.0804321734782249 no 3055 0.0835723971390413 979 5725375 SGTC_2625 euphol 100 µM -1.38268094692203 0.0802490404774551 no 3056 0.0833813582665976 993 6708538 A triterpene alcohol. SGTC_2748 diazoxide 86.69 µM -1.3871788915685 0.0795897576457293 no 3057 0.0826936101741044 972 3019 A potassium channel activatior. SGTC_3125 9127534 49.47 µM -1.38741554773746 0.0795551837690683 no 3058 0.0826575433657946 996 1639235 SGTC_2555 cholic acid 100 µM -1.38980595668017 0.0792065979614679 no 3059 0.0822939044036251 993 6708657 Influences liver metabolism. SGTC_247 mechlorethamine 29.705 µM -1.39299175371897 0.0787438224626804 no 3060 0.081811142171289 998 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_381 3461-2219 42.7 µM -1.39690127615068 0.0781787204505304 no 3061 0.0812216304019662 1029 2883159 SGTC_2107 5363541 170.161 µM -1.39915036928724 0.0778550220000039 no 3062 0.0808839479606888 999 244052 SGTC_2129 girgensonine 121.053 µM -1.40167980346683 0.0774921921221033 no 3063 0.0805054421486436 1011 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1590 st077108 57.8 µM -1.40176198509766 0.0774804253085467 no 3064 0.0804931669293056 996 5489485 SGTC_1828 st055811 49 µM -1.40626299071253 0.0768380388463249 no 3065 0.0798230227553 1006 5877589 SGTC_2103 5378138 10 µM -1.41024909920457 0.0762725268439256 no 3066 0.0792330712776174 993 244142 SGTC_1329 1447-1697 50.6 µM -1.41091918742319 0.0761777727382317 no 3067 0.0791342219205046 1021 2840515 SGTC_2747 doxorubicin 7.63 µM -1.41239051946994 0.0759700327937383 no 3068 0.0789175032057259 961 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3284 9108171 64.8615 µM -1.41269803639252 0.0759266684917408 no 3069 0.0788722645959553 984 8687505 SGTC_3309 9129340 25.759 µM -1.4141990558537 0.0757152736863167 no 3070 0.0786517325624007 1009 17158987 SGTC_3014 9081533 49.47 µM -1.41429297715283 0.0757020612790387 no 3071 0.0786379490550509 1019 21367265 SGTC_2669 eugenol 100 µM -1.41439922171441 0.0756871174102655 no 3072 0.0786223592427374 1004 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1399 3562-5772 25 µM -1.4149720543769 0.0756065841360764 no 3073 0.0785383449118781 1001 23847490 SGTC_443 clozapine 122 µM -1.41911494058499 0.0750260872806829 no 3074 0.0779327544050042 1023 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_882 0843-0131 351 µM -1.4208845500272 0.0747791700330915 no 3075 0.0776751626187191 1001 5425421 SGTC_10 0279-0212 42.575 µM -1.42235462577622 0.0745745192298975 no 3076 0.0774616641541834 1029 39851 YBR002C RER2 SGTC_142 0335-0849 62.6745 µM -1.42327492281767 0.0744466214487303 no 3077 0.0773282368153799 977 3889043 YPR107C YTH1 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.4291875647398 0.0736289059900994 no 3078 0.0764751654320301 1002 77254 SGTC_2115 tiliquinol 12.7705 µM -1.43135415602033 0.0733309926892227 no 3079 0.0761643700757188 1010 71208 A bioactive hydroxyquinoline. SGTC_1515 3460-0031 42.1 µM -1.4379678386491 0.0724272922245298 no 3080 0.0752215898333803 998 2876596 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.43900037321628 0.072286978971832 no 3081 0.0750752085048302 1029 688798 SGTC_2819 7996655 46.38 µM -1.44156117293652 0.0719398856344298 no 3082 0.074713104206549 997 6456960 SGTC_2771 fluoxetine 41.05 µM -1.44518099501474 0.0714514331593122 no 3083 0.0742035265953785 1008 3386 A selective serotonin reuptake inhibitor. SGTC_1574 spiramycin 23.7 µM -1.45063507148265 0.0707202814688834 no 3084 0.0734407519965739 1003 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1217 1183-1422 255 µM -1.4516773054551 0.0705812203406236 no 3085 0.0732956762329102 1010 2849664 SGTC_1324 1418-0026 34.4 µM -1.45705341877361 0.0698672428561069 no 3086 0.0725508175842106 1029 1372513 SGTC_1421 4029-0249 71.4 µM -1.45798814500572 0.0697436752506531 no 3087 0.0724219053549539 1019 2894095 SGTC_518 1021-0119 62.6 µM -1.45860992332578 0.0696615715010182 no 3088 0.0723362503995943 1008 1097762 SGTC_182 3448-4371 550.524 µM -1.46101107595963 0.0693452056957207 no 3089 0.0720062009283042 1003 3491403 SGTC_2861 9024595 19.48 µM -1.47012993810661 0.0681538174708693 no 3090 0.0707632827055999 1017 16482810 SGTC_72 0744-0168 198.391 µM -1.47224947984565 0.067879173469465 no 3091 0.0704767601422152 1033 677577 SGTC_2375 9072683 200 µM -1.47450064921017 0.0675884103461881 no 3092 0.0701734215185354 1018 16798029 SGTC_652 0437-0092 114 µM -1.47539474738139 0.0674731951657811 no 3093 0.0700532233566377 1011 3091274 SGTC_143 4032-1194 15.74 µM -1.47704302455026 0.0672611929531093 no 3094 0.0698320523070979 1015 1806963 SGTC_1088 bifonazole 369 nM -1.47794588324312 0.0671452853269573 no 3095 0.06971113188856 1019 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2474 5321570 43.32 µM -1.47821435791767 0.067110848765372 no 3096 0.0696752060190039 1030 2841384 SGTC_1525 8-methoxypsoralen 92.5 µM -1.47866846090906 0.0670526332222731 no 3097 0.0696144727885597 1040 4114 Related to psoralen; DNA damaging agent. SGTC_407 eburnamonine 100 µM -1.48245031024979 0.0665693199388725 no 3098 0.0691102579003903 1003 3195 SGTC_2866 9034245 58.44 µM -1.48286729592758 0.0665161954223488 no 3099 0.06905483600232 1016 6462273 SGTC_1668 st014914 51.6 µM -1.48388663375207 0.0663864686353074 no 3100 0.0689194992122986 1030 2839556 SGTC_864 0469-0573 172 µM -1.48530750036628 0.066205967948867 no 3101 0.0687311929676414 1045 689425 SGTC_179 1273-0063 6.77 µM -1.48919383866746 0.0657142061298435 no 3102 0.0682181663987527 1036 3108139 SGTC_85 0868-0259 160.055 µM -1.49012885260388 0.0655963168146251 no 3103 0.0680951795433139 997 83173 SGTC_282 k297-0036 65.7 µM -1.49090048852974 0.0654991502436623 no 3104 0.0679938115548526 1018 5061378 SGTC_1169 aniline yellow 25.8 µM -1.4934562417765 0.0651781195511727 no 3105 0.0676589001827541 1012 6051 A DNA damaging agent. SGTC_1634 st006576 41 µM -1.49518071239726 0.0649621978451504 no 3106 0.0674336429152938 1014 3915356 SGTC_1799 st045822 46.1415 µM -1.49545919813594 0.0649273806603151 no 3107 0.0673973204133706 981 3674992 SGTC_2999 9069765 71.4286 µM -1.49797933728501 0.0646129630991831 no 3108 0.0670693094906921 1005 2097066 SGTC_1969 st069479 40.1 µM -1.49799684345698 0.0646107831379712 no 3109 0.0670670352850792 1016 3895485 SGTC_198 3454-2873 16.191 µM -1.50018988594301 0.064338145439279 no 3110 0.0667826112003633 1011 710957 SGTC_2707 st078556 66.6 µM -1.50059362922624 0.0642880499082191 no 3111 0.0667303500641918 1001 17250899 SGTC_1805 st050013 60.3 µM -1.50243323197639 0.0640601799011302 no 3112 0.0664926296427864 1010 4037144 SGTC_1086 cerivastatin 2.18 µM -1.50442651238946 0.0638139833471533 no 3113 0.0662357910113498 1001 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1115 galangin 695.678 nM -1.50517858212373 0.0637212842217996 no 3114 0.0661390850358391 1037 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3107 9121808 49.47 µM -1.50750958457298 0.0634346333718037 no 3115 0.0658400444821806 973 662681 SGTC_2967 9089538 49.85 µM -1.50854835381364 0.0633072163221731 no 3116 0.0657071204594924 1019 728216 SGTC_2941 9056145 11.23 µM -1.50902904447622 0.0632483215341307 no 3117 0.0656456802953862 1009 2119517 SGTC_884 0851-0618 334 µM -1.50912690650747 0.0632363365905657 no 3118 0.065633177378829 1013 9642473 SGTC_1415 3966-0071 78.1 µM -1.50961997685184 0.0631759782679576 no 3119 0.0655702104759809 1015 2893185 SGTC_2586 curcumin 80 µM -1.50974894952859 0.0631601977131866 no 3120 0.065553747920252 1038 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_279 1273-0055 2.93 µM -1.51041368553094 0.0630789120854874 no 3121 0.065468949351013 1036 2847562 SGTC_2983 9022671 12.99 µM -1.51276731293923 0.0627917592945007 no 3122 0.0651693872216299 1010 6405161 SGTC_2186 6124449 200 µM -1.51642337113968 0.0623477256233872 no 3123 0.0647061665681151 1020 3834182 YLR033W RSC58 SGTC_1974 st069448 26.9 µM -1.51823035702251 0.0621291706288546 no 3124 0.0644781686003027 1013 6323587 YNR016C ACC1 SGTC_2360 9040895 200 µM -1.52131713467033 0.0617572079019646 no 3125 0.0640901361927241 1017 4914414 SGTC_563 tetrahydrosecaminediol 614 µM -1.52341750015315 0.0615051052761004 no 3126 0.0638271432409617 1036 334274 A psychoactive constituent of the cannabis plant. SGTC_2130 NSC 7 2.4545 µM -1.52534801410692 0.0612740991457948 no 3127 0.0635861589325671 1034 21448 SGTC_1665 st014639 11.4 µM -1.52549630152754 0.0612563830829276 no 3128 0.0635676776676849 1021 981133 YIL048W NEO1 SGTC_1499 4480-0877 67.3 µM -1.53433002123124 0.0602082115280965 no 3129 0.062474241846207 1015 2861909 SGTC_2955 9076254 12.21 µM -1.53808263102203 0.0597672142275283 no 3130 0.0620142061220674 1017 16459619 SGTC_1924 st058459 75.1 µM -1.54208081441681 0.0593001463526446 no 3131 0.0615269782566236 1012 688683 SGTC_313 3474-0040 5.03 µM -1.54331899515985 0.059156083909139 no 3132 0.0613766985159013 1036 1043375 YIL048W NEO1 SGTC_1508 1080-0625 72.9 µM -1.54361069933085 0.0591221840853073 no 3133 0.0613413357385363 988 767111 SGTC_671 0560-0003 407 µM -1.54599841219631 0.0588452732639303 no 3134 0.0610524756451187 1036 3238678 SGTC_3096 9117468 49.47 µM -1.54660270029913 0.0587753536431321 no 3135 0.0609795390970624 1009 41316311 SGTC_464 bw-b 70c 158 µM -1.55673258467039 0.0576129494968065 no 3136 0.0597669944654334 1034 5353454 SGTC_269 exalamide 29 µM -1.55757535172989 0.0575170624579266 no 3137 0.0596669726951445 1037 3316 A derivative of salicylamide. SGTC_2935 9038016 29.96 µM -1.5616814351418 0.0570516814375562 no 3138 0.0591815271969588 1010 6463195 SGTC_1309 pyrazolanthrone 13.4 µM -1.56567653818821 0.056601729174921 no 3139 0.0587121807949398 1030 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2545 solidagenone 89.61 µM -1.56977414967197 0.0561431410816483 no 3140 0.0582338317776984 1001 6708572 An anti ulcer agent SGTC_3168 9103419 49.47 µM -1.57283942073103 0.0558020078798618 no 3141 0.0578780025861676 1037 16649256 SGTC_3010 9080089 71.4286 µM -1.57750311337856 0.0552861263083857 no 3142 0.0573399031461756 1026 17027233 SGTC_1691 st019933 84.6 µM -1.57876388688182 0.0551473126258712 no 3143 0.0571951123962099 1047 6176082 SGTC_758 0868-0029 16 µM -1.58108635239421 0.0548923254053348 no 3144 0.0569291473932117 1007 762687 SGTC_1644 st010134 20.9 µM -1.58269437113879 0.0547163250194628 no 3145 0.0567455709477841 1031 3818134 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.58296350950101 0.0546869110000732 no 3146 0.0567148908749881 990 279621 SGTC_2407 paclitaxel 400 µM -1.58416399018926 0.0545558631819953 no 3147 0.0565782027581039 1030 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2463 5473429 200 µM -1.58920031067404 0.0540087887676181 no 3148 0.0560075881845079 1028 5399405 SGTC_492 tmb-8 126 µM -1.5898576888544 0.0539377020665338 no 3149 0.0559334433989212 1032 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1061 3448-9325 110 µM -1.59385349935985 0.0535072006091775 no 3150 0.0554844257973629 1025 723482 SGTC_2199 6590217 200 µM -1.59612647448189 0.0532635318218405 no 3151 0.0552302794812687 992 703109 SGTC_762 1165-0429 115 µM -1.5994886869884 0.0529047077829841 no 3152 0.0548560301688447 1023 5967793 SGTC_3261 9137475 49.47 µM -1.60257542291937 0.0525769740048197 no 3153 0.0545142117197584 1004 17027690 SGTC_2024 5144227 134 µM -1.60534084018183 0.0522847265500824 no 3154 0.0542094080281609 1024 3475211 SGTC_1666 st014829 29 µM -1.60744623118223 0.0520630962928885 no 3155 0.0539782577300229 1045 3858230 SGTC_1773 st048542 73.5835 µM -1.6145658869331 0.0513191492778118 no 3156 0.0532023689162313 1035 3237138 SGTC_415 dibenzyl ketone 100 µM -1.62013523773966 0.0507431119522224 no 3157 0.0526016146905004 1033 7593 SGTC_2061 5245884 80.95 µM -1.62524026841223 0.0502196332052427 no 3158 0.0520556866314399 1054 573863 SGTC_1020 4335-0961 93.3 µM -1.62738653226775 0.0500008408654439 no 3159 0.0518275150234816 1040 669075 SGTC_2849 9019321 12.99 µM -1.63134589547114 0.0495992143633209 no 3160 0.0514086771524659 1030 16489627 SGTC_2288 7946289 167.31 µM -1.63246231682746 0.0494864342726754 no 3161 0.0512910653162564 1052 1246052 SGTC_225 nsc-122657 1.016 µM -1.63253843685863 0.049478752141176 no 3162 0.0512830540872848 1029 275685 SGTC_1162 k048-0130 20.1 µM -1.63320135997003 0.0494118893236929 no 3163 0.0512133270286973 1027 6797406 SGTC_2914 7968218 45.32 µM -1.63406315386493 0.0493250761350684 no 3164 0.0511227952908164 1015 2977111 SGTC_1988 st071872 53.4 µM -1.63489737362961 0.0492411566766909 no 3165 0.0510352815758609 1041 16414116 SGTC_80 0159-0065 512.242 µM -1.63539031293322 0.0491916223991681 no 3166 0.0509836259124321 1029 1548079 SGTC_697 0508-1955 564 µM -1.63830534881975 0.0488995104578089 no 3167 0.0506790062285834 1035 6243113 SGTC_717 1532-0246 73.2 µM -1.64077240005577 0.0486533748402631 no 3168 0.0504223347639553 1037 9561992 SGTC_351 caspofungin 25 nM -1.64468589626401 0.0482649613207048 no 3169 0.0500173013983334 1033 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1008 4106-0037 6 µM -1.65074958841582 0.0476680449620395 no 3170 0.0493948588237277 1027 2905394 SGTC_2717 st081029 62.2815 µM -1.65124457695292 0.047619579932611 no 3171 0.0493443220933655 1034 5292846 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.66271638936326 0.0465073746917558 no 3172 0.0481846099645808 1015 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.66333357105405 0.0464481342840917 no 3173 0.0481228411321576 1020 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3105 9121040 49.47 µM -1.66381752175295 0.0464017244834591 no 3174 0.0480744506703366 1010 41448907 SGTC_2004 4023728 41.89 µM -1.66532310068387 0.0462575808051777 no 3175 0.047924156088296 1021 360084 YDR527W RBA50 SGTC_283 0987-0079 11.7 µM -1.66722392647905 0.046076110083951 no 3176 0.0477349433989154 1041 411556 SGTC_66 0109-0187 42.4 µM -1.67233291053131 0.0455911913936093 no 3177 0.0472293467191367 1025 759417 SGTC_3119 9125183 49.47 µM -1.67505295725451 0.0453346971368213 no 3178 0.0469619208667997 1033 22695334 SGTC_2034 5197015 53.07 µM -1.67570256237076 0.0452736128681969 no 3179 0.0468982338423289 1043 780676 SGTC_3048 9093155 49.47 µM -1.67646596309782 0.0452019127111486 no 3180 0.0468234788964609 1028 25236002 SGTC_393 acivicin 6.25 µM -1.68244379234937 0.0446436165050072 no 3181 0.0462414077913661 990 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2204 7233102 200 µM -1.68643288389771 0.0442741568287253 no 3182 0.0458562260688811 1032 2172480 SGTC_88 0180-0332 8.668 µM -1.68807259853057 0.0441230070135667 no 3183 0.0456986468563337 1039 3101745 SGTC_3310 9130229 44.1445 µM -1.68885548050299 0.0440509873919615 no 3184 0.0456235643153613 1047 7761258 SGTC_2443 5493264 126.67 µM -1.69166853963714 0.0437929876547274 no 3185 0.0453545950608035 1056 5340055 SGTC_2305 7443522 69.23 µM -1.69203959037821 0.0437590479196741 no 3186 0.0453192126364219 1028 5415886 SGTC_2752 diclazuril 33.15 µM -1.69237221454395 0.0437286410762252 no 3187 0.045287513346255 1024 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3176 9106582 49.47 µM -1.698393692839 0.0431811293901154 no 3188 0.0447167408552298 1049 17018027 SGTC_2831 7999036 19.48 µM -1.7001520082006 0.0430223006304039 no 3189 0.0445511683745913 1043 2988270 SGTC_2201 6605497 169.863 µM -1.70301613020041 0.0427645951472078 no 3190 0.0442825249161236 1056 670741 SGTC_2121 5257820 149.641 µM -1.70383375705936 0.0426912568103739 no 3191 0.0442060747335626 1038 791256 SGTC_442 cape 100 µM -1.70462669826092 0.0426202298430988 no 3192 0.0441320343806429 1059 5281787 SGTC_1200 1643-0193 18.4 µM -1.70886672362023 0.0422420533432414 no 3193 0.043737819847574 1048 5403974 SGTC_1948 st076329 66.6 µM -1.71744083831875 0.0414856076768371 no 3194 0.0429493276748596 1038 24208413 SGTC_3342 9147791 14.508 µM -1.7177325204932 0.041460068529286 no 3195 0.0429227073706999 1034 1838168 SGTC_2650 prasterone 100 µM -1.71922461135919 0.0413296230475977 no 3196 0.0427867405299149 1051 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3011 9081274 71.4286 µM -1.72300056876855 0.0410009971257633 no 3197 0.0424442110911619 1051 6625322 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.72422014202409 0.0408953101780127 no 3198 0.042334054650165 1031 3256 An antibiotic and ribosome inhibitor. SGTC_1997 st073024 93.8 µM -1.72784108053228 0.0405828249838749 no 3199 0.0420083600151071 1058 686268 SGTC_2696 st077691 74.316 µM -1.73183123404957 0.0402407243004506 no 3200 0.0416518076172543 1040 757133 SGTC_702 1488-0190 94 µM -1.73410008134528 0.0400472488773006 no 3201 0.0414501635513218 1043 949357 SGTC_609 0986-0026 86.3 µM -1.73578586477023 0.0399039840896435 no 3202 0.0413008521868099 1027 2848610 SGTC_2380 9035439 200 µM -1.73619590017166 0.0398692006562297 no 3203 0.0412646009750065 1042 6462575 SGTC_1487 3970-0795 2.82 µM -1.73683807238501 0.0398147745105372 no 3204 0.0412078783936094 1036 3765103 SGTC_323 4013-0906 34.3 µM -1.74075176976433 0.0394843805606412 no 3205 0.0408635497030993 1037 2910086 SGTC_467 ro 31-8220 72.8 µM -1.74309045126445 0.0392880161426809 no 3206 0.040658908147216 1035 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_642 0335-0876 158 µM -1.74371343276783 0.0392358425475636 no 3207 0.0406045359380289 1055 6812350 SGTC_3271 9137798 49.47 µM -1.74551085921345 0.0390856272450369 no 3208 0.0404479919349465 1011 6498326 SGTC_2948 9070189 9.45 µM -1.75490355271749 0.0383082553235553 no 3209 0.0396379031940325 1015 6473636 YDL196W YDL196W SGTC_1971 st069429 63.5 µM -1.75495131157238 0.0383043350849438 no 3210 0.0396338181160696 1041 1246522 YGL099W LSG1 SGTC_3226 9131256 49.47 µM -1.75559770030156 0.0382513090667707 no 3211 0.0395785625942304 1032 17178073 SGTC_2576 guaiol 23.12 µM -1.75600517586877 0.0382179128821332 no 3212 0.0395437623950856 1024 227829 SGTC_2584 androsterone 48.74 µM -1.76005802257815 0.0378870393404716 no 3213 0.0391989845955882 994 2754130 A steroid. SGTC_3086 9117350 49.47 µM -1.76215126130771 0.0377170653629017 no 3214 0.0390218721445562 1036 2679265 SGTC_2065 5221596 34.26 µM -1.76438707794501 0.0375362018830104 no 3215 0.0388334161272076 1036 788581 SGTC_477 mead ethanolamide 10 µM -1.76479793472273 0.0375030433095656 no 3216 0.038798865945619 1067 16061185 SGTC_942 3253-1115 227 µM -1.77041980328029 0.0370517235672923 no 3217 0.0383286165990029 1046 46497897 SGTC_865 0488-0499 301 µM -1.77616007331947 0.036595489009256 no 3218 0.0378532685160544 1035 9634651 SGTC_575 k072-0246 11.9 µM -1.78369646488708 0.0360034879246001 no 3219 0.037236500447899 1058 6796779 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.78608513678161 0.0358174975307971 no 3220 0.0370427371696448 1064 390807 SGTC_1400 3771-8998 51.5 µM -1.78658313044512 0.035778821335294 no 3221 0.0370024451258889 1074 670767 SGTC_410 α-linolenic acid 100 µM -1.7868935724046 0.0357547284821421 no 3222 0.0369773457880397 1052 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2221 6807166 181.081 µM -1.79556707740054 0.0350869499791106 no 3223 0.0362816979125791 1056 674925 SGTC_1769 st044406 64.4 µM -1.79640401888354 0.0350230583324026 no 3224 0.0362151425818704 1063 670903 SGTC_3149 9097855 49.47 µM -1.79807403369741 0.0348958556663639 no 3225 0.0360826382361094 1042 25236625 YMR079W SEC14 SGTC_2384 9036245 200 µM -1.79848931381035 0.0348642833157371 no 3226 0.0360497502884785 1031 6462766 SGTC_1048 3161-0300 24.5 µM -1.82049383073097 0.0332246006383337 no 3227 0.034341917451609 1039 2165101 SGTC_1846 st056244 14.8 µM -1.82093198746416 0.0331926074292626 no 3228 0.0343085980312375 1052 5393182 SGTC_84 0443-0269 128.823 µM -1.82174011642445 0.0331336662564048 no 3229 0.0342472139417377 1040 6150058 SGTC_2764 methyldopa 94.69 µM -1.82408720552918 0.032962969198839 no 3230 0.0340694447465212 1056 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_939 1165-0479 45.3 µM -1.82752605690894 0.0327141807953989 no 3231 0.0338103560442939 1039 1377347 SGTC_2309 7664088 163.95 µM -1.83227021329929 0.032373501645512 no 3232 0.0334555862959422 1033 704922 SGTC_1671 st016596 74.5 µM -1.83342226777934 0.0322912155439617 no 3233 0.0333698993014062 1067 2829167 SGTC_1096 rimcazole 32.2 µM -1.83556838287915 0.032138388413979 no 3234 0.0332107584086619 1054 18528119 A dopamine reuptake inhibitor. SGTC_3095 9117207 49.47 µM -1.83691320850328 0.0320429266301268 no 3235 0.0331113545281963 1060 17015229 SGTC_3111 9122088 49.47 µM -1.84880586796058 0.0312088811539275 no 3236 0.0322429248744521 1063 16876704 SGTC_1972 st070201 17.4 µM -1.85062526581578 0.0310828826022225 no 3237 0.0321117411472804 1058 2829099 SGTC_196 k015-0023 18.111 µM -1.85828452121043 0.0305570637418498 no 3238 0.0315643103787456 1053 5211998 SGTC_1935 st074532 41.6 µM -1.85902898599655 0.0305063503728079 no 3239 0.0315115149499075 1047 2829742 SGTC_2220 6782180 200 µM -1.85978091816126 0.0304551991134503 no 3240 0.0314582640741736 1051 833803 SGTC_3334 9142812 21.919 µM -1.88405240532349 0.0288418758261563 no 3241 0.0297789436061331 1055 45283678 SGTC_3205 9113483 49.47 µM -1.88535911609608 0.0287570736507549 no 3242 0.0296906849176336 1042 17018033 SGTC_891 0929-0073 133 µM -1.88987134996671 0.0284658336951316 no 3243 0.0293875840544072 1067 5603632 SGTC_167 3672-0051 66.205 µM -1.8942104839684 0.0281880850857808 no 3244 0.0290985385462658 1053 3237971 SGTC_1398 3558-0053 112 µM -1.90011911859822 0.0278135035797638 no 3245 0.0287087446365631 1073 4532369 SGTC_1402 3909-7673 35.9 µM -1.90539100471805 0.0274827988322648 no 3246 0.0283646318181672 1063 5328014 SGTC_1494 4358-1428 177 µM -1.91136653834045 0.0271119249400459 no 3247 0.0279787468513653 1054 1564571 SGTC_2711 st079103 59.1 µM -1.91271188041494 0.0270290042385466 no 3248 0.0278924737132304 1060 54693780 SGTC_1495 4469-0029 237 µM -1.93725052232411 0.0255533148708174 no 3249 0.0263573635791 1061 793680 SGTC_940 3232-1287 54.8 µM -1.93754439609629 0.0255360592841854 no 3250 0.0263394159621071 1055 1585493 YIL048W NEO1 SGTC_1885 st057546 99.9 µM -1.94162791766194 0.0252972924446621 no 3251 0.0260910803316592 1047 702008 SGTC_2021 4019055 173 µM -1.94239355932541 0.0252527336226553 no 3252 0.0260447372073436 1042 44827708 YER133W GLC7 SGTC_2670 beta-carotene 100 µM -1.94432037175858 0.0251408878933396 no 3253 0.0259284147573553 1052 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_716 1683-5115 658 µM -1.95382923481252 0.0245949892682415 no 3254 0.0253607078299573 1058 723597 SGTC_2780 5215298 71.43 µM -1.9592794850549 0.024286602433122 no 3255 0.0250400324647257 1062 2834131 SGTC_959 1222-0044 107 µM -1.96378076169608 0.0240343648501544 no 3256 0.0247777610263151 1057 6083612 SGTC_234 nsc-17383 10.7 µM -1.9690400436904 0.0237424429790801 no 3257 0.0244742464525719 1055 408974 SGTC_1403 3909-7815 62.9 µM -1.97249878209387 0.0235520916720497 no 3258 0.024276347602253 1064 6615483 SGTC_2263 7948595 193.29 µM -1.9842180449531 0.0229166407344602 no 3259 0.0236157688814267 1057 2971371 SGTC_2175 5807670 165.306 µM -1.98722037640009 0.0227561899758004 no 3260 0.0234489903796873 1047 241186 SGTC_3314 9135860 59.4275 µM -1.99365875787168 0.0224152996881648 no 3261 0.0230946796801539 1053 25252478 SGTC_3136 9095672 49.47 µM -1.99460652158937 0.0223654843514818 no 3262 0.0230429058757934 1057 17217380 SGTC_2808 7946468 45.46 µM -1.99511454778182 0.0223388204906642 no 3263 0.0230151940227712 1057 2970879 SGTC_2341 7987486 176.74 µM -1.99986896502199 0.0220905811753861 no 3264 0.0227572075803837 1054 1258686 SGTC_2296 7971656 126.45 µM -2.01038436370923 0.0215498076987053 no 3265 0.0221952620543901 1064 666570 SGTC_2052 5265182 7.135 µM -2.01359159830786 0.0213871131231257 no 3266 0.0220262146281131 1070 1239884 SGTC_318 1488-0629 67.2 µM -2.01752149209754 0.0211891769305503 no 3267 0.0218205602418937 1072 3662576 SGTC_790 1575-0012 79.1 µM -2.02637259229574 0.0207490444202805 no 3268 0.0213633086936095 1040 378741 YLR208W SEC13 SGTC_219 mitoxanthrone 164.414 µM -2.04564421276462 0.0198174593789156 no 3269 0.0203956940798044 1077 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1739 st037196 92.5 µM -2.05147883626108 0.0195425128833532 no 3270 0.0201101692888583 1059 612214 SGTC_953 1188-0045 9.7 µM -2.08277856399682 0.0181222614004837 no 3271 0.0186357061837935 1048 6144426 SGTC_2946 9065502 71.43 µM -2.08622804987454 0.0179712596337505 no 3272 0.0184789852730425 1033 16489101 SGTC_62 0180-0423 3.232 µM -2.08767331435816 0.0179083126200077 no 3273 0.0184136568113747 1062 30102 YGL099W LSG1 SGTC_1705 st027868 56.3335 µM -2.09079878598592 0.0177728286696365 no 3274 0.0182730524960116 1052 292948 SGTC_2369 9071472 200 µM -2.09230803894468 0.0177077187940464 no 3275 0.0182054845278779 1072 17296037 SGTC_2770 toltrazuril 17.5 µM -2.10482505009506 0.0171755308721977 no 3276 0.0176532698899908 1048 68591 Kills coccidiodes. SGTC_1079 idarubicin 2.36 µM -2.11582375833932 0.0167192365749013 no 3277 0.0171798998345702 1073 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2791 5663188 71.43 µM -2.11641131742306 0.0166951555883858 no 3278 0.0171549201816874 1066 54690634 SGTC_968 1309-0633 340 µM -2.12045602205405 0.0165301881188798 no 3279 0.0169838032654181 1071 3761976 SGTC_1260 0700-1617 7.75 µM -2.12371457890421 0.0163983012100437 no 3280 0.0168470087793565 1062 2853078 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.13010954581604 0.0161420888786902 no 3281 0.0165812852112916 1050 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2398 5228213 48.84 µM -2.13203889215925 0.0160654669228807 no 3282 0.016501824723046 1069 80771 YMR134W ERG29 SGTC_262 fenpropimorph 62.5 µM -2.13607166297198 0.0159063158798881 no 3283 0.0163367865371732 1084 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_561 1550-0330 72.9 µM -2.14438931061096 0.0155823297479031 no 3284 0.0160008530189003 1078 6812934 SGTC_1315 1237-0019 3.69 µM -2.15214533655802 0.0152853384922264 no 3285 0.0156929546852746 1054 825140 SGTC_3018 9082602 49.47 µM -2.15389089860333 0.0152191722536059 no 3286 0.0156243644423762 1041 17332089 SGTC_3336 9143619 71.43 µM -2.15461650049298 0.0151917404982906 no 3287 0.0155959283684243 1082 45595730 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.16107295903864 0.014949515764371 no 3288 0.01534485200936 1061 88881 An O-methylated flavonoid and antioxidant. SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.16362252706856 0.0148547829748104 no 3289 0.0152466656002989 1068 6708630 An antioxidant. SGTC_2447 5741742 33.78 µM -2.16994112991076 0.0146222285501992 no 3290 0.0150056529891069 1073 1776504 SGTC_1946 st076057 65.1 µM -2.18984449067138 0.0139100542081297 no 3291 0.0142677584298773 1077 953009 SGTC_1521 st012942 49.4 µM -2.19023764465085 0.013896293181885 no 3292 0.0142535032136235 1077 24207259 SGTC_1220 1838-0075 193 µM -2.2063149240225 0.013343528313669 no 3293 0.0136809785787781 1059 5529645 SGTC_822 1487-0950 154 µM -2.22760722203211 0.0126407621841034 no 3294 0.012953359325419 1059 1958375 SGTC_2605 digitonin 300 nM -2.2330546302589 0.0124661982202166 no 3295 0.0127726710013377 1078 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2616 abietic acid 100 µM -2.24071754434172 0.0122241732212267 no 3296 0.0125221884663255 1075 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_417 st075190 100 µM -2.24187831723993 0.0121878688621662 no 3297 0.0124846188803601 1082 222757 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.24367605079679 0.0121318273403676 no 3298 0.0124266260565003 1073 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_19 0279-0214 38.434 µM -2.25118889568317 0.0119000367511061 no 3299 0.0121867879549218 1086 3566274 YBR002C RER2 SGTC_2239 6685329 187.64 µM -2.2526245637781 0.0118561826013371 no 3300 0.0121414154888014 1061 805680 SGTC_352 k048-0007 5.11 µM -2.25632753209483 0.0117437177746853 no 3301 0.0120250631840004 1062 6811911 SGTC_148 3253-0744 288.01 µM -2.26275861688296 0.0115505953609344 no 3302 0.0118252866125412 1065 6893655 SGTC_3313 9133968 57.047 µM -2.28564719490852 0.0108854651933503 no 3303 0.0111374533952566 1063 1494643 SGTC_2284 7945075 39.21 µM -2.2951378751169 0.0106196014159667 no 3304 0.0108626120554963 1067 1245402 SGTC_3230 9131665 49.47 µM -2.305047683308 0.0103480502901332 no 3305 0.0105819515150463 1075 15943720 SGTC_1832 st054113 55 µM -2.31492481930605 0.0100834382979996 no 3306 0.0103085234088181 1080 1251267 SGTC_328 k915-0120 63.5 µM -2.32323458552395 0.00986540950483726 no 3307 0.0100832768802022 1081 6624543 SGTC_1257 0669-0121 16 µM -2.33539770312383 0.00955370334015315 no 3308 0.00976132715461177 1072 4307855 SGTC_1397 3532-0190 20.1 µM -2.35832869884934 0.00898939901053042 no 3309 0.00917871507238387 1086 5322280 SGTC_3013 9080133 71.4286 µM -2.35927587210483 0.00896673165814247 no 3310 0.00915531896740054 1082 17050193 SGTC_910 3454-3003 490 µM -2.36033069837241 0.00894154694457585 no 3311 0.0091293251878026 1074 820824 SGTC_2840 9008771 71.43 µM -2.37500383955418 0.00859758882351962 no 3312 0.00877438382265328 1079 2992978 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.38143650294179 0.00845049497539451 no 3313 0.00862263178661623 1080 688662 SGTC_1338 1486-1223 76 µM -2.4182263238963 0.00765093600990107 no 3314 0.00779818639800896 1076 3444526 SGTC_370 0180-0345 38.7 µM -2.4247872105516 0.00751556711813174 no 3315 0.00765868094197315 1058 3989527 SGTC_2176 5809774 33.9695 µM -2.44465497221062 0.00711842275236537 no 3316 0.00724953873257096 1065 2870539 SGTC_2032 5185112 25.99 µM -2.4495914548855 0.00702266424523163 no 3317 0.00715091924663885 1086 5718189 SGTC_645 0845-0943 5.41 µM -2.45667818461637 0.00688718288646621 no 3318 0.00701141207531961 1079 1885106 SGTC_396 dithiazanine 1.25 µM -2.51431612826068 0.00586832839859378 no 3319 0.00596317374029136 1082 10578 An antihelmenthic. SGTC_176 1486-1328 72.834 µM -2.54551792743037 0.00537455263852447 no 3320 0.00545578803808341 1080 22310231 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.55233899225159 0.00527166036859401 no 3321 0.0053501176347331 1091 2724278 An inhibitor of dopamine biosynthesis. SGTC_2899 9053889 58.44 µM -2.58996147001254 0.00473501356684069 no 3322 0.00479933373428321 1082 6470052 SGTC_2859 9028643 45.46 µM -2.64733908929322 0.00401012124099003 no 3323 0.00405639794064784 1073 17151580 SGTC_427 1354-0053 47.3 µM -2.67871497827454 0.00365726429627749 no 3324 0.00369526366881651 1086 6813657 SGTC_58 0957-0393 9 µM -2.69040295481714 0.0035331138718896 no 3325 0.00356828941755215 1084 6997992 SGTC_1891 st059073 26.2 µM -2.69753914726662 0.00345918630947653 no 3326 0.0034927035464781 1089 688754 SGTC_264 promethazine 12.5 mM -2.70422252259185 0.00339121296348223 no 3327 0.00342322118233154 1086 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2839 9003951 25.97 µM -2.70941531732717 0.00333923084181053 no 3328 0.00337009544223075 1084 2990634 SGTC_2045 5106652 78.05 µM -2.71641863862606 0.00327025923972399 no 3329 0.00329962065725177 1083 673349 SGTC_2843 9000894 45.46 µM -2.74156651956302 0.00303302865692484 no 3330 0.00305734891085839 1086 2242070 SGTC_2847 9005661 71.43 µM -2.74868278419067 0.00296877231572564 no 3331 0.00299176313663917 1086 2991449 SGTC_3354 9151612 71.43 µM -2.77685794598532 0.00272623690450592 no 3332 0.00274435808510542 1086 27261949 SGTC_3139 9095020 49.47 µM -2.7789166089115 0.00270923719546906 no 3333 0.00272702623637886 1085 25236292 SGTC_2886 9058944 51.95 µM -2.79994880489674 0.002540965391714 no 3334 0.00255553559183457 1090 4949929 SGTC_1916 st067606 49.2 µM -2.8464863523211 0.00220173848888063 no 3335 0.00221023120037265 1074 19590279 SGTC_2027 5150920 200 µM -2.87952272154132 0.00198643205093745 no 3336 0.00199138798914203 1092 786715 SGTC_2693 st077581 40.7 µM -2.94416877015471 0.00161951024923596 no 3337 0.00161911680982741 1069 25238761 SGTC_2046 4110841 106 µM -2.9524586393828 0.00157721923656508 no 3338 0.00157627150288709 1089 44119630 YMR134W ERG29 SGTC_3004 9076122 71.4286 µM -2.9776088889536 0.00145500040536157 no 3339 0.00145253215911691 1087 44782551 SGTC_1491 4138-0063 26.5 µM -3.00524215443503 0.00133072855151029 no 3340 0.00132684743109459 1091 23883227 SGTC_1938 st074717 56.4 µM -3.0303897113086 0.00122614782156182 no 3341 0.00122119184653865 1081 17250979 SGTC_1183 1254-0324 198 µM -3.03491873275807 0.00120813238796652 no 3342 0.00120300254057722 1088 5799357 SGTC_2269 7935389 174.42 µM -3.09830959874096 0.000980150392116402 yes 3343 0.00097313993985972 1088 97605 SGTC_2608 thymoquinone 42.66 µM -3.17037318014325 0.000769344893652831 yes 3344 0.000761216368325211 1088 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_61 0978-8327 98.565 µM -3.28983959344049 0.000509619686909098 yes 3345 0.000501222556623422 1089 6150059 YHR072W ERG7 SGTC_2898 9056270 58.44 µM -3.32222938178182 0.000454752763126549 yes 3346 0.000446506241824155 1091 19154699 SGTC_1913 st060213 96.1 µM -3.4620964835859 0.000275019263854597 yes 3347 0.00026799248613897 1090 688959 SGTC_2025 5147754 141 µM -3.46803073506068 0.000269106547632022 yes 3348 0.000262143660549745 1092 315777 YLR208W SEC13 SGTC_2439 5492030 7.2 µM -3.73735562281609 9.69944786397808e-05 yes 3349 9.29829050750436e-05 1092 5722370 SGTC_1027 k015-0025 8.67 µM -3.98994917634484 3.5049650787268e-05 yes 3350 3.30437273188198e-05 1095 3598955 SGTC_1036 k216-0215 33.5 µM -4.29525108973438 9.46357416822164e-06 yes 3351 8.72478620800461e-06 1075 622330 SGTC_57 miconazole 162.5 nM -4.64633727607214 1.88571869798232e-06 yes 3352 1.68940211727306e-06 1091 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_56 0957-0365 83.25 µM -4.86150619763131 6.62722940990442e-07 yes 3353 5.82479662948163e-07 1095 6752360 SGTC_893 0958-0369 48.9 µM -5.28987923639184 7.25904320039994e-08 yes 3354 6.11985737777342e-08 1091 6819948 SGTC_350 k064-0020 19.8 µM -6.98318858031619 2.1141887511691e-12 yes 3355 1.44277330024465e-12 1095 2790705