SGTCid condition conc unit DED1|YOR204W.score DED1|YOR204W.strain.pval DED1|YOR204W.strain.significant DED1|YOR204W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_217 ketoconazole 989 nM 7.13341864467791 2.04994638358016e-11 yes 1 4.89530941080635e-13 2 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1378 2093-0007 380 nM 7.09740288065507 2.56407405789012e-11 yes 2 6.35615388073305e-13 1 3618014
SGTC_2950 9072895 21.46 µM 6.81499478061305 1.42792387300107e-10 yes 3 4.71335940428878e-12 1 17332245
SGTC_2158 5657123 3.6195 µM 6.22743750522735 4.10976825367249e-09 yes 4 2.37062882297678e-10 3 2858827
SGTC_2612 dictamnine 15.46 µM 5.99999627240842 1.39692440060269e-08 yes 5 9.86610293700726e-10 18 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_689 0833-0039 98 µM 5.43386385276499 2.43766753590732e-07 yes 6 2.7573331871121e-08 2 5374726
SGTC_256 clotrimazole 625 nM 5.3142789228886 4.3109337382479e-07 yes 7 5.35402475143445e-08 11 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2921 7974240 10.71 µM 5.20663079704047 7.12979083272086e-07 yes 8 9.61500813844542e-08 6 2979074 YDR527W RBA50
SGTC_932 2857-0803 154 µM 5.14827511045867 9.32816865727388e-07 yes 9 1.31446363054046e-07 3 674898
SGTC_2584 androsterone 48.74 µM 5.10892625260449 1.11638251126522e-06 yes 10 1.61997386998929e-07 18 2754130 A steroid.
SGTC_3304 9125678 46.087 µM 4.95323996027506 2.24426064174636e-06 yes 11 3.64939378952395e-07 24 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2778 tioconazole 65.09 nM 4.94421589941645 2.335534166574e-06 yes 12 3.82254706645323e-07 19 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1158 4092-0494 91.8 µM 4.86263254416678 3.33879620571585e-06 yes 13 5.79173814429811e-07 1 1148199
SGTC_1080 nisoldipine 24.4 µM 4.5682301864102 1.15872521863855e-05 yes 14 2.45929849775588e-06 3 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3351 9150312 21.596 µM 4.54853249744812 1.25614183283659e-05 yes 15 2.70106510866578e-06 6 4904905
SGTC_2404 5161160 200 µM 4.51564155808272 1.43638883862941e-05 yes 16 3.1562680735673e-06 6 2831543
SGTC_2926 9010726 65.15 µM 4.49848530754563 1.53990909120087e-05 yes 17 3.42196626588472e-06 2 2994293
SGTC_265 mycophenolic acid 32.932 µM 4.44718970553027 1.89338000777153e-05 yes 18 4.35005000603792e-06 4 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1053 3366-3204 134 µM 4.32881302480388 3.02544285436842e-05 yes 19 7.4957569951233e-06 5 3632071 YPR165W RHO1
SGTC_576 1073-0113 22.7 µM 4.31017890995488 3.25371692391616e-05 yes 20 8.15612602092434e-06 38 5439563
SGTC_2831 7999036 19.48 µM 4.17920116756605 5.38236767728471e-05 yes 21 1.46267418195361e-05 4 2988270
SGTC_391 gliotoxin 8.33 µM 4.12412672442884 6.62345100418348e-05 yes 22 1.86071986764508e-05 2 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_57 miconazole 162.5 nM 4.10561156478663 7.09804142972993e-05 yes 23 2.01623301656025e-05 24 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2994 9053520 71.4286 µM 3.99551015323395 0.000106504845153777 yes 24 3.22775451330952e-05 8 4647384
SGTC_2709 st078560 56 µM 3.99524688201784 0.000106606985314432 yes 25 3.2313435781814e-05 5 17250903
SGTC_61 0978-8327 98.565 µM 3.94980179181544 0.000125684386545439 yes 26 3.91079680244781e-05 8 6150059 YHR072W ERG7
SGTC_2261 9010538 184.68 µM 3.93849577547222 0.000130904880211074 yes 27 4.0997018789566e-05 5 6457250
SGTC_2932 9016711 44.54 µM 3.93039089395698 0.000134771635303279 yes 28 4.24039357206462e-05 9 7117328
SGTC_2367 9070478 135.38 µM 3.91003687600932 0.000144959572406169 yes 29 4.61410159951397e-05 10 572802
SGTC_3266 9136860 49.47 µM 3.80667525153288 0.000208797688677436 yes 30 7.0423748121791e-05 14 4871271 YPR165W RHO1
SGTC_395 anisomycin 6.25 µM 3.7804078701096 0.000228773015484214 yes 31 7.82858250452587e-05 4 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2735 sertaconazole 140 nM 3.77355068058806 0.00023427367847381 yes 32 8.04702534168176e-05 4 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3339 9145883 14.936 µM 3.73328702956445 0.00026914177003154 yes 33 9.44985033710736e-05 1 2030670
SGTC_2311 7694451 200 µM 3.68654648012739 0.000315662233123023 yes 34 0.000113658969536548 13 2163142
SGTC_227 fluconazole 33.516 µM 3.65279228573891 0.000353795836060066 yes 35 0.000129702031120346 52 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1092 toremifene 6.32 µM 3.65141413513025 0.000355440205628259 yes 36 0.000130400147996466 6 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_176 1486-1328 72.834 µM 3.62617506357215 0.00038683916642699 yes 37 0.000143825190355421 12 22310231
SGTC_682 0kpi-0099 17 µM 3.55541276171016 0.000489128874001021 yes 38 0.000188693076192255 40 1714895 YML126C ERG13
SGTC_1680 diphenhydramine 100 µM 3.51567404533419 0.000557033851225137 yes 39 0.000219319575169407 18 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2470 5664817 21.68 µM 3.43037678409224 0.000733191232681913 yes 40 0.000301371824838242 8 2859561
SGTC_2325 6158266 200 µM 3.40226087183439 0.000801679637684697 yes 41 0.000334154058558264 11 3623240
SGTC_1037 k284-1091 78.7 µM 3.39579221288114 0.000818248354625478 yes 42 0.000342151432599662 9 3334711
SGTC_526 4469-0568 170 µM 3.38200234224745 0.000854626478815639 yes 43 0.000359797655290607 10 2901964
SGTC_3137 9097352 49.47 µM 3.36674501482549 0.000896605236866132 yes 44 0.000380304905608872 16 44120435
SGTC_1882 5615643 20 µM 3.35387108605509 0.000933491782271858 yes 45 0.000398447400303303 7 2253075
SGTC_2400 5203494 178.7 µM 3.34202179673687 0.0009686693807457 yes 46 0.000415852646626457 25 6777674
SGTC_3209 9113616 49.47 µM 3.30729031713169 0.00107890876554809 no 47 0.000471016034988833 14 16649353
SGTC_2805 7950783 58.44 µM 3.26196690417424 0.00124006209020045 no 48 0.000553210301124969 13 1178958 YDL195W SEC31
SGTC_1226 3909-7979 35.4 µM 3.24227170927344 0.00131672489678944 no 49 0.000592904546105498 12 6615510
SGTC_2401 5128683 200 µM 3.20709598787799 0.00146450624429946 no 50 0.000670411244671292 22 708373
SGTC_2382 9035899 200 µM 3.18895203628883 0.00154651194567226 no 51 0.000713947836614073 12 6462679
SGTC_197 4544-0043 41.561 µM 3.17910667218133 0.00159274243246696 no 52 0.000738648568720613 30 896523
SGTC_2900 5328528 85.29 µM 3.17802085197618 0.00159791744635679 no 53 0.000741420430034568 10 795359
SGTC_1567 st069303 68.4 µM 3.16139642374225 0.0016790862268532 no 54 0.000785073241645211 20 5581319
SGTC_1193 1488-0126 41.5 µM 3.15848608061573 0.00169367620567816 no 55 0.000792954413027202 10 1384710
SGTC_1867 st057372 64 µM 3.14845697390774 0.00174484217822846 no 56 0.000820674420119961 6 688837
SGTC_2130 NSC 7 2.4545 µM 3.13607280206864 0.00180996240498297 no 57 0.000856133463782017 7 21448
SGTC_3103 9120822 49.47 µM 3.12525003018107 0.00186867385432623 no 58 0.000888269938529288 20 17141819
SGTC_2127 5253358 187.912 µM 3.10897173934295 0.00196024492284825 no 59 0.0009386983741811 13 20612
SGTC_143 4032-1194 15.74 µM 3.08136789082625 0.0021248829245461 no 60 0.00103025944931706 39 1806963
SGTC_745 0469-0705 296 µM 3.07757743778273 0.00214844419972372 no 61 0.00104345304356535 41 3486736
SGTC_1139 k015-0024 46.9 µM 3.03141710772934 0.00245499785508172 no 62 0.00121704371823167 8 2766652
SGTC_1373 2887-0003 58.5 µM 3.02583878469912 0.00249460653840957 no 63 0.00123972232218281 30 776948
SGTC_46 0329-0187a 2.197 µM 3.02565089439802 0.00249595065004076 no 64 0.00124049287571417 21 46494817
SGTC_1227 3909-8010 46.6 µM 3.01288603858478 0.00258881475667253 no 65 0.00129388037190129 7 15982272
SGTC_2086 5274770 176.623 µM 2.99902333569209 0.00269319242689101 no 66 0.00135423280643209 20 689278
SGTC_2052 5265182 7.135 µM 2.99227148849848 0.00274539313100601 no 67 0.00138454943346293 20 1239884
SGTC_660 4031-1742 102 µM 2.9874468612463 0.00278325144639661 no 68 0.00140659097625427 28 6738706
SGTC_364 0083-0097 67.7 µM 2.97318730026877 0.00289791400515225 no 69 0.00147362271379321 20 5207356
SGTC_398 bronopol 33.3 µM 2.96615340350055 0.00295602822283353 no 70 0.00150775018689526 25 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1238 0333-0287 48.8 µM 2.95457970128478 0.00305393953511799 no 71 0.00156547634910859 10 7226
SGTC_1088 bifonazole 369 nM 2.94133118788411 0.00316959763994499 no 72 0.00163402458607333 10 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_514 4466-0038 2.65 nM 2.93764913902022 0.00320243407239824 no 73 0.00165355531768569 60 5722064
SGTC_70 0141-0289 43.283 µM 2.91814749321423 0.0033815068651822 no 74 0.00176058875955572 39 352408
SGTC_2199 6590217 200 µM 2.91232388850834 0.00343669987817593 no 75 0.00179375217124471 11 703109
SGTC_1564 D-Arginine 115 µM 2.88477110083645 0.0037089586139258 no 76 0.00195849172674526 21 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.88355430635517 0.00372141638129522 no 77 0.00196607420333648 18 23665772 A membrane-active detergent.
SGTC_3264 9137442 49.47 µM 2.86624070333501 0.00390278761400982 no 78 0.00207689141983701 18 17015726
SGTC_252 miconazole 1.30953 nM 2.85075855885271 0.00407163809520474 no 79 0.00218075368874142 35 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3032 9089427 49.47 µM 2.85054579451863 0.00407400339143915 no 80 0.00218221325265884 12 17173707
SGTC_381 3461-2219 42.7 µM 2.81081062852645 0.00453790387095515 no 81 0.00247084309078679 15 2883159
SGTC_2830 7992007 71.43 µM 2.79912783703317 0.00468299154762514 no 82 0.00256204232959911 24 1952075
SGTC_160 3453-0671 289.699 µM 2.75664839661671 0.00524604297594416 no 83 0.0029198553873182 21 5322268
SGTC_121 0557-0495 61.343 µM 2.74150654116443 0.00546085072629336 no 84 0.00305790715139968 30 3104427
SGTC_2038 4100038 30.985 µM 2.73381665345607 0.00557290683661956 no 85 0.00313024470579195 36 3596803
SGTC_3246 9135460 32.98 µM 2.73224071582697 0.0055961217839187 no 86 0.00314525813280515 10 41446951
SGTC_2774 tamoxifen 10.92 µM 2.69998106590981 0.0060905859351093 no 87 0.00346717111900381 15 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_528 3492-0019 172 µM 2.69613932460733 0.00615197788249204 no 88 0.00350741596423197 47 2869262
SGTC_3056 9094900 49.47 µM 2.67498257815669 0.00649998976298208 no 89 0.00373665668286432 23 25236784
SGTC_2058 5236698 133 µM 2.66797473840468 0.0066190430982836 no 90 0.00381549977320983 18 766665
SGTC_906 1165-0455 526 µM 2.65238057000653 0.00689090747233801 no 91 0.00399631989992449 19 3252859
SGTC_90 0870-0863 4.608 µM 2.64635596180937 0.00699855096840747 no 92 0.00406820738520114 24 1738164
SGTC_2539 epi(13)torulosol 80 µM 2.63479426445791 0.00720929162109186 no 93 0.00420941471426293 25 6708597
SGTC_1667 st014849 34.6 µM 2.62396327744033 0.00741177018903476 no 94 0.00434565777263224 20 5348460
SGTC_621 3584-0052 32.1 µM 2.60536762798754 0.00777111004712984 no 95 0.00458878643412663 25 2273927
SGTC_525 k781-2675 26.7 µM 2.60435805775333 0.00779105032383018 no 96 0.00460232695188591 70 3651118 YDL195W SEC31
SGTC_787 4152-0075 138 µM 2.59532381178741 0.00797150132840334 no 97 0.00472509200009851 25 9566539
SGTC_2178 5812956 200 µM 2.58533271485665 0.00817533457363564 no 98 0.00486425343030508 14 5403383
SGTC_1800 st050079 29.0735 µM 2.58234806743959 0.00823710760353494 no 99 0.004906527965114 51 3645560
SGTC_1775 st081588 35.1725 µM 2.57894515455352 0.00830803731893733 no 100 0.00495512598598045 33 1426443 YGL099W LSG1
SGTC_539 4859-0462 2.54 µM 2.57830606938557 0.00832141795827218 no 101 0.00496430063618395 41 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1886 st057356 49.9 µM 2.57804796355132 0.00832682732817066 no 102 0.00496801026873718 23 24207747
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.57443931510014 0.00840278121838894 no 103 0.00502013489300584 17 756377
SGTC_2852 9023854 51.95 µM 2.57299101940029 0.00843343518042333 no 104 0.00504119119383117 32 19798528
SGTC_60 0986-0278 202 µM 2.56973809374838 0.00850264315886911 no 105 0.00508877136824847 21 3110598
SGTC_1936 st074407 74.3 µM 2.55354007381004 0.00885473660509782 no 106 0.00533170035394123 39 809813
SGTC_998 3996-0085 177 µM 2.54376018289114 0.00907345159752054 no 107 0.00548331745022417 23 715391
SGTC_1611 st001856 99.4 µM 2.5423750116028 0.00910480860749741 no 108 0.00550509859303216 33 647478
SGTC_2552 juarezic acid 87.02 µM 2.52445742230148 0.00951905349589035 no 109 0.00579385204875234 11 1549512
SGTC_1371 2421-0008 32.7 µM 2.52291557227642 0.00955545846268599 no 110 0.00581931701206641 60 2827552
SGTC_2161 5662504 8.5105 µM 2.52019455717376 0.00962000195521718 no 111 0.00586449922258401 31 2859334
SGTC_3316 9136639 10.545 µM 2.49698568963071 0.0101861853689211 no 112 0.00626270056340129 22 4903665
SGTC_2289 7946404 165.07 µM 2.48149004965699 0.0105801934766386 no 113 0.00654171815690188 49 1246120 YPR165W RHO1
SGTC_802 4112-3352 742 µM 2.47846500322677 0.0106586416264331 no 114 0.00659745274268352 17 704594
SGTC_1405 3909-7894 12 µM 2.47180748253557 0.0108330765788021 no 115 0.00672159444193728 14 7104060
SGTC_974 1326-0144 138 µM 2.46625532933202 0.0109804446105076 no 116 0.00682669851872732 35 5411856
SGTC_835 0312-0010 67.2 µM 2.46461658225435 0.0110242730902176 no 117 0.00685799676482609 22 1626196
SGTC_3088 9117578 49.47 µM 2.46015943543552 0.0111442506647006 no 118 0.00694376531734441 30 678341
SGTC_600 1495-0418 41.6 µM 2.45661660519308 0.0112404249897475 no 119 0.00701261388805933 30 5377768
SGTC_153 4077-0274 519.67 µM 2.45559570002758 0.0112682722340083 no 120 0.00703256486075469 31 3121976
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2.44962563432675 0.0114323214339987 no 121 0.00715024056641484 22 2374 Ca(2+)-ATPase inhibitor.
SGTC_2170 morpholine 200 µM 2.4384893134765 0.0117438827657145 no 122 0.00737439738556621 19 121171 Reacts with secondary amines.
SGTC_3257 9139206 32.98 µM 2.42503546868785 0.0121300881620831 no 123 0.00765344559535581 23 4910041
SGTC_2240 6690706 185.951 µM 2.4218855543585 0.0122220839786299 no 124 0.00772010616313566 25 805876
SGTC_1458 k015-0034 6.33 µM 2.4124143489809 0.0125023495712607 no 125 0.00792363019367852 23 3598957
SGTC_404 fumagillin 50 µM 2.41132553426271 0.0125349229371219 no 126 0.00794732719150534 27 12015870 A methionine aminopeptidase binder.
SGTC_2944 9067346 25.62 µM 2.40222101489392 0.0128101845494345 no 127 0.00814792970893694 41 6473075
SGTC_3343 9148379 18.9835 µM 2.3909909376977 0.0131568988131537 no 128 0.0084014838089883 17 1955036
SGTC_2046 4110841 106 µM 2.38856237397228 0.0132329350391251 no 129 0.00845721843993365 42 44119630 YMR134W ERG29
SGTC_3263 9137018 49.47 µM 2.38394219362746 0.0133786374345426 no 130 0.00856414632970683 38 43844957
SGTC_2938 9059746 27.26 µM 2.35686945495865 0.0142605482063795 no 131 0.00921486224977107 41 6471769
SGTC_62 0180-0423 3.232 µM 2.34825565143048 0.0145514516319833 no 132 0.00943078516264481 49 30102 YGL099W LSG1
SGTC_2839 9003951 25.97 µM 2.33877658576563 0.0148774649671963 no 133 0.00967349955624238 22 2990634
SGTC_75 0159-0059 199.013 µM 2.33352577156904 0.0150607446764404 no 134 0.0098102836673378 45 5377270
SGTC_1479 0549-0158 134 µM 2.32657885601768 0.0153062061508448 no 135 0.00999384548925567 36 5440202
SGTC_2536 dehydroabietamide 32.04 µM 2.32416846844404 0.0153921736146055 no 136 0.0100582332800845 29 3983547
SGTC_866 0495-0101 262 µM 2.31323406751183 0.0157873785259574 no 137 0.010354886732462 38 635694
SGTC_1612 st002233 45.4 µM 2.31308131701238 0.015792960497958 no 138 0.0103590843540831 27 1035021
SGTC_944 3370-0224 231 µM 2.30861511048835 0.0159569193123322 no 139 0.0104824743472269 31 4580514
SGTC_922 1866-0035 480 µM 2.29896210860274 0.0163162817633542 no 140 0.0107535455246815 44 3156169
SGTC_2499 avocadenofuran 51.48 µM 2.27622055986567 0.0171904016241908 no 141 0.0114164059819971 28 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2487 5918373 44.05 µM 2.27539377915552 0.0172229204031846 no 142 0.0114411591120113 46 2876279
SGTC_191 3914-0123 66.505 µM 2.2549854160339 0.0180424393582162 no 143 0.0120671221045943 41 3144412
SGTC_1624 st003710 6.25 µM 2.2535865040779 0.0180998117305732 no 144 0.0121110965748442 27 24207033
SGTC_1336 1486-0901 104 µM 2.24370282776887 0.0185096098825206 no 145 0.0124257640284049 22 5006114
SGTC_2844 9010103 25.97 µM 2.23784091874781 0.0187563696029989 no 146 0.0126157154817804 42 2480525
SGTC_1884 5633444 25 µM 2.23542655386467 0.0188588143589929 no 147 0.0126946792207647 53 5724239
SGTC_1357 1503-1303 39.5 µM 2.22298796254822 0.019394175412089 no 148 0.0131083058383591 49 292895
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.20385368600877 0.0202429053103125 no 149 0.013767317785782 27 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1334 1486-0610 236 µM 2.20221979388741 0.0203168165721034 no 150 0.0138248932615249 42 3742339
SGTC_3331 9141060 1.957 µM 2.20107495161002 0.0203687412120063 no 151 0.01386535910541 30 4906567 YPR165W RHO1
SGTC_1081 sertraline 6 µM 2.19671030462938 0.0205677340040706 no 152 0.0140205712267248 39 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2558 carylophyllene oxide 100 µM 2.19167919271544 0.020799153184332 no 153 0.0142013395966192 26 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1518 st038567 90.8 µM 2.18153275858909 0.0212725761755623 no 154 0.014572017108876 30 77966
SGTC_842 0271-0008 11.1 µM 2.17331775809924 0.0216625271214739 no 155 0.0148782049271645 50 1221709
SGTC_54 0159-0055 9 µM 2.17115519464835 0.02176617856385 no 156 0.0149597214811977 39 3319099
SGTC_1383 3049-0032 20.7 µM 2.15890414177134 0.0223613109095196 no 157 0.0154288022437974 54 712864
SGTC_1511 0906-3109 28.5 µM 2.15466073087941 0.0225706225624345 no 158 0.0155941964326742 56 2882180
SGTC_304 1310-0298 97 µM 2.14965744941069 0.0228195354445273 no 159 0.0157911602710047 44 1550234
SGTC_3267 9137951 49.47 µM 2.14456183226301 0.0230754154163294 no 160 0.0159939483593503 27 16643986
SGTC_727 3032-0951 202 µM 2.13917238205309 0.0233486753103413 no 161 0.01621085501727 29 3652836
SGTC_8 0354-0001 70 µM 2.13646290701934 0.0234870786181605 no 162 0.0163208506429955 57 4993152
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.13272920214501 0.0236789311887336 no 163 0.0164734734643856 19 4620898
SGTC_1502 4534-4282 27.7 µM 2.1315385636366 0.0237403873657353 no 164 0.0165223994781013 26 3278949
SGTC_2692 st077426 47.7 µM 2.11119389274143 0.0248113973026856 no 165 0.0173778247816303 60 25238571
SGTC_3034 9090421 49.47 µM 2.1082281978256 0.0249708549975156 no 166 0.0175056276570527 24 17173761
SGTC_1198 1612-1005 86.7 µM 2.10552156067759 0.0251171328907362 no 167 0.017622966269295 51 6998509
SGTC_1366 1683-0113 21.9 µM 2.10468672606328 0.0251623954815787 no 168 0.0176592933496258 35 708623
SGTC_1742 st038235 28.8875 µM 2.10296513104563 0.0252559518043028 no 169 0.0177344088246923 58 564103 YBR002C RER2
SGTC_538 2922-0838 53.3 µM 2.10245604362063 0.0252836728222039 no 170 0.017756673143796 47 777039
SGTC_309 k408-0051 1.48 µM 2.09629880377379 0.0256209725596319 no 171 0.0180278464017905 91 3640463
SGTC_346 4513-0042 7.16 µM 2.07355175044729 0.026899914899211 no 172 0.0190604801015678 56 2827372
SGTC_1078 idebenone 36.1 µM 2.06544165223989 0.0273686037379609 no 173 0.019440615469831 56 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2683 piperine 63.03 µM 2.05980004428144 0.0276986372622115 no 174 0.0197088301763962 42 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3334 9142812 21.919 µM 2.05888476519907 0.0277524924322109 no 175 0.0197526394287826 53 45283678
SGTC_2203 7227154 166.4 µM 2.05293977027884 0.0281044247074301 no 176 0.0200392096329752 24 896304
SGTC_748 act1.228 77.9 µM 2.05136348686165 0.0281983584283126 no 177 0.020115781040215 44 4421505 YNR035C ARC35
SGTC_656 4090-1979 187 µM 2.04974758003034 0.0282949245295311 no 178 0.0201945346725177 41 22330961
SGTC_402 epigallocatechin gallate 10 µM 2.03964916946074 0.0289046559658235 no 179 0.0206926405109262 60 65064 An antioxidant.
SGTC_1441 4106-0040 13 µM 2.03252794290511 0.0293411623692967 no 180 0.021050118956363 52 2904180
SGTC_339 3091-4833 71.4 µM 2.03241396955224 0.0293481928017134 no 181 0.0210558825262157 80 3240077
SGTC_1045 1348-1485 165 µM 2.02555307977244 0.0297739897854725 no 182 0.0214053019283153 41 6810614
SGTC_312 4092-0653 6.84 µM 2.02319737870362 0.0299213649607691 no 183 0.0215264009176335 85 1148278
SGTC_2087 5276107 200 µM 2.02224360757982 0.0299812057246852 no 184 0.0215755956335565 44 144405
SGTC_3001 9076041 71.4286 µM 2.01741316292622 0.0302857998044546 no 185 0.021826207379135 40 16004211
SGTC_2972 9093619 59.92 µM 2.01438025526093 0.0304783537022797 no 186 0.0219848128707356 37 25236256
SGTC_2588 indole-3-carbinol 100 µM 2.01270386835229 0.030585219003971 no 187 0.0220728960964171 49 3712 Induces cell cycle arrest.
SGTC_340 k038-0059 454 µM 2.00854958042458 0.0308513820220669 no 188 0.0222924614787778 45 23733424
SGTC_2362 9071156 126 µM 2.00608263597801 0.0310103431825409 no 189 0.0224237160663107 45 653133
SGTC_2595 hexamethylquercetagetin 100 µM 2.00263766796396 0.0312334582118636 no 190 0.0226080968412223 64 386331
SGTC_930 2810-3379 265 µM 2.00232363968303 0.0312538622709476 no 191 0.0226249675708088 55 1015764
SGTC_863 0466-0191 129 µM 2.0005964581988 0.031366283437437 no 192 0.0227179477957684 62 765160 YPR165W RHO1
SGTC_2619 obliquin 87.91 µM 1.99277788369826 0.0318793800899261 no 193 0.0231428872817959 77 6708593 A bioactive alkalod. YER133W GLC7
SGTC_733 4069-0007 56.1 µM 1.98971339460117 0.0320823704263754 no 194 0.0233112581633386 63 5717425 YNL287W SEC21
SGTC_1522 st012842 45.6 µM 1.98425723012002 0.0324464253020649 no 195 0.0236135857500745 57 3491067 YOR116C RPO31
SGTC_87 0100-0052 35.5 µM 1.97629062717195 0.0329841008987733 no 196 0.0240609352764696 79 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2815 7968870 71.43 µM 1.9734294131112 0.0331789909534413 no 197 0.0242233296395381 56 2977326 YHR190W ERG9
SGTC_3094 9117742 49.47 µM 1.96847273577374 0.0335188569581477 no 198 0.0245068350633118 61 17149698
SGTC_3201 9113999 49.47 µM 1.96629403295024 0.0336691487935665 no 199 0.0246323278509122 57 16649224
SGTC_2012 4023501 200 µM 1.96130071484923 0.034015691769931 no 200 0.0249219769795942 80 3477460
SGTC_382 3229-0966 23.2 µM 1.95611391950514 0.0343787627905442 no 201 0.02522586788927 45 5722370
SGTC_2767 sibutramine 71.45 µM 1.9404167043336 0.035496998882346 no 202 0.0261645340640656 36 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_711 k292-0785 179 µM 1.93351854581366 0.0359977545976873 no 203 0.0265861753445675 63 4146315
SGTC_2846 9008642 19.48 µM 1.9308884766367 0.0361901955534526 no 204 0.0267484227684614 70 2992898
SGTC_2710 st078562 53.7235 µM 1.92883619598893 0.0363409443660471 no 205 0.0268756003756386 61 17250908
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.92858398394113 0.0363595058344519 no 206 0.0268912644582802 34 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2954 9074818 52.69 µM 1.92059938838557 0.0369511524523422 no 207 0.0273911161707824 60 16648742
SGTC_1235 benzylparaben 21.5 µM 1.9196635628545 0.0370210081205812 no 208 0.0274502047809034 58 7180
SGTC_1005 4092-0690 4.4 µM 1.91581209658472 0.0373096420132003 no 209 0.0276945087278123 78 1529343
SGTC_3068 9116768 49.47 µM 1.90904445138039 0.037821269929157 no 210 0.0281281788091991 61 41904888
SGTC_1406 3909-7906 11.9 µM 1.89458853929525 0.0389333082560742 no 211 0.0290734671581656 53 X1406
SGTC_652 0437-0092 114 µM 1.89299806270353 0.0390572669721277 no 212 0.0291790635496853 53 3091274
SGTC_541 4513-1321 94 µM 1.88599849592298 0.0396066238253675 no 213 0.0296475786711472 74 747515
SGTC_2292 7671323 168.05 µM 1.88237693734827 0.0398933169778333 no 214 0.0298924274870991 102 937504
SGTC_1801 st050089 28.441 µM 1.8790549846985 0.0401577734898949 no 215 0.0301184929026848 67 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1550 gossypolone 36.6 µM 1.87660513878921 0.0403537136841381 no 216 0.0302861162757138 58 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1987 st072290 61.9 µM 1.86986846349612 0.0408965224568291 no 217 0.0307510430678237 52 54697379
SGTC_666 0272-0154 136 µM 1.85568012097901 0.0420591275114284 no 218 0.03174958296476 84 6870312
SGTC_1337 1486-1011 40.3 µM 1.85242069711066 0.0423299513019978 no 219 0.0319827177625064 47 X1337
SGTC_2681 menadione 3.18 µM 1.85173982213629 0.0423867025908741 no 220 0.0320315963573681 61 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_980 1473-0395 201 µM 1.85146707866818 0.0424094531609437 no 221 0.0320511933375437 57 768876
SGTC_2865 9030313 51.95 µM 1.84973080335023 0.0425545141605597 no 222 0.0321761792495586 42 42562754
SGTC_2736 butenafine 14.65 µM 1.84932747227971 0.0425882687189526 no 223 0.0322052705800057 65 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_157 1348-1695 65.819 µM 1.84824692031998 0.0426788062284541 no 224 0.0322833152846691 96 5380510
SGTC_2434 5670830 169.91 µM 1.83378830175463 0.0439053030291492 no 225 0.0333427124495833 63 1549830
SGTC_2555 cholic acid 100 µM 1.83365663908488 0.0439166009747029 no 226 0.0333524894774494 43 6708657 Influences liver metabolism.
SGTC_2027 5150920 200 µM 1.83277634315729 0.0439921992409878 no 227 0.0334179193109149 48 786715
SGTC_236 1509-0011 5.31 µM 1.82999412157161 0.0442318217516759 no 228 0.0336254089301118 109 3107280
SGTC_2208 7283366 200 µM 1.82751752939194 0.0444460055652581 no 229 0.0338109965109259 48 898663
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.82669586005038 0.0445172505639039 no 230 0.0338727555377907 43 6708561
SGTC_1579 chlormadinone acetate 49.4 µM 1.82605279113293 0.0445730737000255 no 231 0.0339211551508019 73 45114258 A steroidal progestin.
SGTC_1113 artemisinin 1.17947 µM 1.81929423781552 0.0451631829279905 no 232 0.0344332760129401 96 2240 An anti-malaria and mitochondrial poison.
SGTC_2982 9019404 25.97 µM 1.81206405976268 0.0458014138899926 no 233 0.0349881494383567 56 22333232
SGTC_771 0250-0039 27.3 µM 1.80731627225677 0.04622444485448 no 234 0.0353564901494962 73 3005115
SGTC_2904 7225135 42.03 µM 1.80551876128646 0.046385420784349 no 235 0.0354967711898762 72 4446116
SGTC_2842 9000675 19.48 µM 1.79948332445523 0.0469292186026474 no 236 0.0359711297014681 64 2989072
SGTC_846 0335-0850 148 µM 1.79873598157519 0.0469969091075983 no 237 0.0360302271550164 58 6819598
SGTC_3311 9131146 2.8755 µM 1.79402491671043 0.0474254175149065 no 238 0.0364045959575513 95 4900406 YPR165W RHO1
SGTC_2594 a-mangostin 100 µM 1.78814286585584 0.0479648244102974 no 239 0.0368764806508548 73 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2726 cimetidine 79.27 µM 1.78269738140898 0.0484685634925257 no 240 0.0373177889239816 52 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_348 k064-0012 10.7 µM 1.78240688198349 0.048495554801783 no 241 0.0373414520275123 87 5066323
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.78125756199574 0.0486024599736322 no 242 0.0374351919611261 75 688801
SGTC_141 0443-0274 32.331 µM 1.78002788626713 0.0487170480607987 no 243 0.0375356985339294 59 1627241
SGTC_2189 6047310 154.431 µM 1.77982173989259 0.0487362790552612 no 244 0.0375525692910121 57 711535
SGTC_1673 st016611 27.3 µM 1.77896423808816 0.0488163388543046 no 245 0.0376228126037864 81 5226799
SGTC_228 caffeine 993.056 µM 1.77836199268034 0.0488726296989071 no 246 0.0376722103735613 35 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_565 1418-0001 44.5 µM 1.77560203169318 0.0491312623445603 no 247 0.037899267453495 66 2862145
SGTC_1706 st031321 9.9705 µM 1.77502856944154 0.0491851377299583 no 248 0.0379465850100632 62 6103185
SGTC_2570 licareol 100 µM 1.75667398571065 0.0509345650604846 no 249 0.0394866970554047 79 443158
SGTC_741 4582-0002 126 µM 1.75546643430896 0.0510513750279309 no 250 0.0395897785881822 61 2912688
SGTC_2386 9075165 157.42 µM 1.75534973210301 0.0510626752614554 no 251 0.0395997523531321 70 16452277
SGTC_3232 9132874 49.47 µM 1.75487917704273 0.0511082591392963 no 252 0.0396399883117536 78 3784940
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.7540540973698 0.0511882648935934 no 253 0.0397106190114677 107 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2511 berberine 10.47 µM 1.7499419091832 0.0515884998033694 no 254 0.0400641690384983 78 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_510 ag-490 170 µM 1.74993166426287 0.0515895000288237 no 255 0.0400650530405399 37 5328779
SGTC_1755 st041960 45.185 µM 1.74958288406554 0.0516235611110279 no 256 0.0400951576450773 82 2257073
SGTC_2808 7946468 45.46 µM 1.74752061492993 0.0518253231771194 no 257 0.0402735360918411 81 2970879
SGTC_2126 5251174 33.877 µM 1.74487488514757 0.0520850852883173 no 258 0.0405033249753804 73 790722
SGTC_3289 9119912 71.43 µM 1.74022205671929 0.052544415451313 no 259 0.0409100170374391 68 17014829
SGTC_2970 9090938 41.86 µM 1.73923681356466 0.0526420905486689 no 260 0.0409965582514669 85 17217104
SGTC_3235 9132602 49.47 µM 1.73906611747663 0.052659027663063 no 261 0.0410115668349784 77 4912240
SGTC_1981 st071826 47 µM 1.73525321114465 0.0530384870313195 no 262 0.0413479826143308 70 11838600
SGTC_1539 benzyladenosine 56 µM 1.73340886860306 0.053222811951785 no 263 0.041511511201544 72 92208 A nucleotide analog.
SGTC_742 0kpi-0133 140 µM 1.73250249186529 0.0533135818065907 no 264 0.0415920669027419 67 2728852
SGTC_1698 5-fluorocytosine 1.055 µM 1.72722399820263 0.0538446413442118 no 265 0.0420637212496545 81 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_178 4092-0806 87.505 µM 1.72484713843965 0.0540851365348738 no 266 0.0422775120587344 91 2169044
SGTC_903 1134-0042 114 µM 1.72409823546626 0.054161087851626 no 267 0.0423450552944873 68 701009
SGTC_1512 0259-0544 12.2 µM 1.7222628397458 0.0543475846784204 no 268 0.0425109580073296 83 18476
SGTC_671 0560-0003 407 µM 1.72070233376336 0.0545065488976609 no 269 0.0426524263426165 46 3238678
SGTC_1634 st006576 41 µM 1.71785366457603 0.0547976827063494 no 270 0.0429116551042225 64 3915356
SGTC_2848 9016370 25.97 µM 1.71696416293532 0.0548888411202117 no 271 0.0429928600532706 59 7894410
SGTC_2269 7935389 174.42 µM 1.71371748667463 0.055222586295182 no 272 0.0432903118875464 78 97605
SGTC_1820 st053765 18.6 µM 1.71088011408955 0.0555155673658467 no 273 0.0435516231519848 58 3690829
SGTC_208 k072-0098 12.366 µM 1.71042345837894 0.0555628350960187 no 274 0.0435937981025017 97 5948901
SGTC_1440 4100-1550 40 µM 1.70725650346352 0.0558915163973833 no 275 0.043887193459194 66 742806
SGTC_296 1222-0039 74.9 µM 1.70573971930154 0.0560494776069011 no 276 0.0440282754812177 62 5984176
SGTC_97 0535-0701 19.132 µM 1.70361456373254 0.0562713879390498 no 277 0.0442265594193978 73 2832013 YGL099W LSG1
SGTC_618 k072-0232 33.2 µM 1.70355929412281 0.0562771684607831 no 278 0.0442317258418122 85 5872756 YGL099W LSG1
SGTC_2286 7945697 125 µM 1.70351664972029 0.056281628860982 no 279 0.044235712433607 70 1245733
SGTC_362 0310-0100 9.03 µM 1.70333469482617 0.056300663602756 no 280 0.04425272565517 62 790235
SGTC_935 2996-0153 430 µM 1.69497831340984 0.0571803260972508 no 281 0.0450397674174434 70 23738523
SGTC_1303 1160-0052 261 µM 1.69299381506759 0.0573908123243833 no 282 0.0452283222432228 63 3562476
SGTC_297 0986-0032 24 µM 1.68269556769139 0.0584929038949718 no 283 0.0462170201062253 83 2847425
SGTC_319 1348-1596 45.5 µM 1.68235536362141 0.0585295932415574 no 284 0.0462499757044699 85 5380505
SGTC_1268 0828-0275 2.46 µM 1.67899168568689 0.0588933227119678 no 285 0.0465768320801871 87 745337
SGTC_148 3253-0744 288.01 µM 1.6783325810133 0.0589648020164456 no 286 0.0466410955005767 71 6893655
SGTC_2918 7977171 22.06 µM 1.67541555143365 0.0592819687569285 no 287 0.0469263637325482 67 2236483
SGTC_579 4491-1009 110 µM 1.67049814807281 0.0598196613134222 no 288 0.0474104227647031 97 1271041
SGTC_1774 st048371 48.465 µM 1.66447381324615 0.060483589670659 no 289 0.0480088899896238 104 4242727
SGTC_169 k015-0017 16.025 µM 1.65887703932693 0.0611055508104707 no 290 0.0485702861244957 77 1840002
SGTC_967 1306-0166 352 µM 1.6505487224803 0.0620403039887725 no 291 0.0494153783688101 91 4437607
SGTC_2459 5811157 9.22 µM 1.64979427988954 0.062125529231077 no 292 0.0494925095560236 76 2870684 YBR192W RIM2
SGTC_1084 voriconazole 435 nM 1.64847120342592 0.0622752104326647 no 293 0.049628007592666 86 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2895 9054447 58.44 µM 1.64634165118823 0.0625167197070349 no 294 0.0498467193840125 72 2697450
SGTC_1401 3807-4679 7.6 µM 1.63884722749087 0.0633724608931328 no 295 0.0506225402965333 88 3291456
SGTC_620 0109-0052 432 µM 1.63350945833648 0.0639874870824093 no 296 0.0511809465532773 79 493037
SGTC_2507 purpurin 79.67 µM 1.62909866022127 0.0644992000124018 no 297 0.0516460674092041 82 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2090 5301565 104.445 µM 1.62667742523298 0.0647814448389572 no 298 0.0519028128637222 96 2056344
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.62483360615592 0.0649970224585647 no 299 0.0520990091239734 72 97141
SGTC_445 e6 berbamine 66 µM 1.62155385222209 0.0653818639294264 no 300 0.0524494552317907 116 6610268 A calcium/calmodulin antagonist.
SGTC_2948 9070189 9.45 µM 1.61900593781812 0.0656820504547829 no 301 0.0527229927690081 69 6473636 YDL196W YDL196W
SGTC_1034 k072-0165 12.7 µM 1.61515341226086 0.06613796959576 no 302 0.0531387382834347 90 5835461
SGTC_594 1487-1584 10.8 µM 1.61365842193693 0.0663155499213325 no 303 0.0533007685903263 91 5013332
SGTC_3065 9113888 49.47 µM 1.61133531518656 0.0665922292790434 no 304 0.0535533287398897 90 16648368
SGTC_728 3030-5151 22.5 µM 1.60869952811836 0.0669072295428837 no 305 0.0538410295230372 57 3125388
SGTC_192 3455-0609 60.9 µM 1.59838020412476 0.0681515819339489 no 306 0.05497919375442 76 3769639
SGTC_2432 5630864 12.22 µM 1.59836766414522 0.0681531048566166 no 307 0.054980588321115 90 5714970
SGTC_2270 7924575 90.91 µM 1.59296284910756 0.0688119435968879 no 308 0.0555842627647383 89 1262135
SGTC_1299 1079-1439 3.74 µM 1.59075469493546 0.0690825229201314 no 309 0.0558323962461081 91 323161
SGTC_2698 st077697 67.5 µM 1.58601475047914 0.0696661070396547 no 310 0.0563679817645074 81 3154499
SGTC_1548 st061468 90.8 µM 1.58512336893697 0.0697762770932096 no 311 0.0564691535025112 57 390799
SGTC_2245 6637752 200 µM 1.58487969526281 0.0698064172005894 no 312 0.0564968353388796 79 681890
SGTC_1709 st033179 39.1045 µM 1.58294483646723 0.0700460965449966 no 313 0.0567170190609355 72 573381
SGTC_26 0302-0163 425.158 µM 1.58062079221253 0.0703348223380619 no 314 0.0569823844039008 110 3100915
SGTC_3309 9129340 25.759 µM 1.57939408637332 0.0704875897130845 no 315 0.0571228464731597 66 17158987
SGTC_825 1988-2224 89.6 µM 1.57802970153621 0.0706578023785477 no 316 0.0572793932560855 100 1180859
SGTC_2070 5230947 200 µM 1.57796873406662 0.0706654156896013 no 317 0.0572863964137197 84 2835538
SGTC_1520 flindersine 88 µM 1.57544362399742 0.0709812928236753 no 318 0.0575770408369152 95 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1666 st014829 29 µM 1.57480235318357 0.0710616846374195 no 319 0.0576510365478943 80 3858230
SGTC_1477 0139-0234 16 µM 1.57366525748623 0.0712044065819745 no 320 0.0577824289348232 87 620880
SGTC_2198 6589944 200 µM 1.56928131131181 0.0717567157270634 no 321 0.0582912024985585 85 5290268
SGTC_117 lucigenin 22.078 µM 1.56872574794434 0.0718269420478306 no 322 0.0583559281844781 83 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1344 1488-0097 29.1 µM 1.56089092068818 0.0728229298145293 no 323 0.0592747449493815 78 747966
SGTC_1807 st050092 58.9 µM 1.56035074903842 0.0728919858272173 no 324 0.0593385083742549 91 5008496
SGTC_425 3825-7017 13.1 µM 1.55993525125535 0.0729451375251297 no 325 0.0593875915177097 105 3397440
SGTC_3118 9124250 49.47 µM 1.55820424580869 0.0731668921246984 no 326 0.0595924194161486 82 1504786
SGTC_272 doxorubicin 8.13 µM 1.55584572853452 0.0734698653527796 no 327 0.0598723906379196 93 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1822 st052468 42 µM 1.55525777335484 0.0735455427930239 no 328 0.0599423448966859 81 2873678
SGTC_923 1900-2434 73.3 µM 1.55148536757282 0.0740325190370303 no 329 0.0603927056348782 116 5910570
SGTC_1114 scopoletin 1.73284 µM 1.5511225205859 0.074079488170681 no 330 0.0604361625822671 78 5280460 A coumarin with genotoxic properties.
SGTC_120 rhodamine 6G 52.259 µM 1.54416799692094 0.0749841297968951 no 331 0.061273819800074 148 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1236 0330-0013 258 µM 1.53975049849957 0.0755631169930937 no 332 0.061810591182592 71 4617066
SGTC_1367 1812-0510 76.9 µM 1.53190825394339 0.0765993571396831 no 333 0.0627725382061138 85 1142582 YDR527W RBA50
SGTC_988 1497-1057 103 µM 1.53137361168944 0.0766703940599631 no 334 0.0628385410181873 91 3533044
SGTC_401 neomycin 50 µM 1.53088824953519 0.0767349266007738 no 335 0.0628985069044801 83 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1796 st049173 110.4 µM 1.52802214676106 0.0771168388008603 no 336 0.0632535196852981 89 94134
SGTC_1410 3909-8106 77.9 µM 1.52743100043152 0.0771957892505358 no 337 0.0633269363410633 109 1039210
SGTC_2149 5554786 194.827 µM 1.52556892536341 0.0774448797828749 no 338 0.0635586279842678 80 745063 YPR165W RHO1
SGTC_1508 1080-0625 72.9 µM 1.52363706949397 0.0777039495901538 no 339 0.0637996988485932 93 767111
SGTC_1001 4048-4355 44.4 µM 1.51782529798758 0.0784872988746246 no 340 0.0645292229147355 112 21824233
SGTC_571 k831-0106 44.2 µM 1.5164925163568 0.0786677810551479 no 341 0.0646974306066446 100 4783639
SGTC_3319 9138450 16.7555 µM 1.51636154030078 0.0786855344865862 no 342 0.0647139791904859 93 2029690
SGTC_1859 st055998 20 µM 1.5150970286025 0.0788570916371711 no 343 0.0648739170303251 92 676301
SGTC_1475 4092-1048 11.7 µM 1.514975410098 0.0788736066276035 no 344 0.064889315732441 102 2881759
SGTC_667 1498-1044 59 µM 1.51445438358317 0.0789443882496488 no 345 0.0649553175186042 92 6739982
SGTC_3127 9126946 49.47 µM 1.51419898491127 0.0789791018109394 no 346 0.0649876895415518 94 27243249
SGTC_342 k048-0088 23.3 µM 1.51263051506743 0.0791925404163923 no 347 0.0651867692516253 106 6820570
SGTC_1777 st045864 34.765 µM 1.50730239131014 0.0799208578918724 no 348 0.0658665824659742 120 4691462
SGTC_1308 1187-1617 41.4 µM 1.50313244517676 0.0804943850673999 no 349 0.0664024468117324 106 2882570
SGTC_2955 9076254 12.21 µM 1.5005902013995 0.0808455632840516 no 350 0.0667307936339833 90 16459619
SGTC_3249 9135183 49.47 µM 1.49978487423755 0.0809570497565256 no 351 0.0668350683361131 91 4902779
SGTC_1908 st060353 56.5 µM 1.49965467626515 0.0809750847678745 no 352 0.0668519383534161 116 4227716
SGTC_1072 oxiconazole 14.9 nM 1.49939374179002 0.081011238516746 no 353 0.0668857580836273 115 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2528 xanthyletin 44.79 µM 1.49860007739352 0.0811212794900356 no 354 0.0669887063227894 90 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1722 st034304 3.6505 µM 1.49853038454927 0.0811309477352679 no 355 0.0669977522103278 108 4036148 YLR033W RSC58
SGTC_972 1319-0219 195 µM 1.49724513535634 0.0813094017866763 no 356 0.0671647424865782 112 23903702
SGTC_1776 st049249 45.9 µM 1.4959622441027 0.0814878235800405 no 357 0.067331747169145 113 1822314
SGTC_718 1130-0073 349 µM 1.49392445608952 0.0817718415751592 no 358 0.0675976827392364 93 6740020
SGTC_47 0149-0135 24.25 µM 1.4935569336542 0.0818231445744633 no 359 0.0676457314453555 103 5239155
SGTC_289 k017-0060 526 µM 1.48852051064567 0.0825286323757839 no 360 0.0683068385841751 91 5512909
SGTC_2062 5245942 200 µM 1.48431874936291 0.0831206986904064 no 361 0.0688621892628362 86 1376160
SGTC_2853 9015042 58.44 µM 1.48098112505419 0.0835932721633255 no 362 0.0693058016383021 79 6457456
SGTC_1671 st016596 74.5 µM 1.47931531256356 0.0838298880954881 no 363 0.0695280311080207 102 2829167
SGTC_198 3454-2873 16.191 µM 1.47733157162461 0.0841123191273311 no 364 0.0697933894816352 114 710957
SGTC_3296 9122258 64.045 µM 1.47676858198947 0.0841926036027513 no 365 0.0698688405417461 89 4730474
SGTC_2272 7805186 180 µM 1.47621878290698 0.0842710625554742 no 366 0.069942584390972 109 2956062 YPR165W RHO1
SGTC_2914 7968218 45.32 µM 1.4688166296773 0.0853327338785884 no 367 0.070941266131862 73 2977111
SGTC_460 trequinsin 123 µM 1.46424348367122 0.0859936369869727 no 368 0.071563716513509 102 5537 A vasodilator.
SGTC_1880 MG-132 525 µM 1.46253396514461 0.0862416746648063 no 369 0.0717974719376778 116 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1772 st048439 82.2 µM 1.46115459819102 0.0864421997081891 no 370 0.0719865097667079 109 2927068 YDL195W SEC31
SGTC_764 1951-2361 146 µM 1.4605541644766 0.0865295963942444 no 371 0.0720689164031937 130 5438930
SGTC_2157 5649910 96.377 µM 1.45805179264347 0.086894542838409 no 372 0.0724131338134286 91 2858091
SGTC_2206 7254556 146.969 µM 1.45618161627809 0.0871680397162313 no 373 0.0726712100685423 84 4398905
SGTC_2338 7999974 200 µM 1.44958178687364 0.0881383442870276 no 374 0.0735875889849945 110 315925
SGTC_1738 st035555 74 µM 1.44856873506414 0.0882879928637112 no 375 0.073729028844477 112 5331140
SGTC_3082 9117008 49.47 µM 1.44814237679454 0.0883510313336058 no 376 0.073788618057502 98 41448529
SGTC_331 k048-0133 24.5 µM 1.44573195083224 0.088708051695486 no 377 0.07412619954049 108 6813582
SGTC_3005 9076496 71.4286 µM 1.44536938158142 0.0887618464883551 no 378 0.0741770794734417 88 21368410
SGTC_3236 9132701 49.47 µM 1.44486341540755 0.0888369578380275 no 379 0.074248127110235 110 24282524
SGTC_2238 6671620 73.2395 µM 1.44453422486425 0.0888858520163522 no 380 0.0742943798580007 91 729941
SGTC_3115 9123671 49.47 µM 1.4403207930492 0.0895134370989466 no 381 0.0748883306412265 87 3286988
SGTC_2995 9067767 71.4286 µM 1.44009554412103 0.089547080187698 no 382 0.074920184796034 79 11673567
SGTC_2322 7413319 38.22 µM 1.43456183218866 0.0903765488847539 no 383 0.0757059987406776 129 1840400
SGTC_2036 5160441 105 µM 1.43390017519589 0.0904761077558195 no 384 0.0758003759374106 136 134534 YIL048W NEO1
SGTC_2616 abietic acid 100 µM 1.43033894301614 0.0910133617547514 no 385 0.076309881458168 106 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_298 1391-0729 10 µM 1.42815071519216 0.0913446534829487 no 386 0.076624241376593 96 3237558
SGTC_2685 mycophenolic acid 18.85 µM 1.42545956871589 0.0917533104776928 no 387 0.077012199693793 88 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_118 0083-0097 135.343 µM 1.42421336396694 0.0919430077923306 no 388 0.077192358742811 149 5207356
SGTC_1111 tnp00062 510.699 nM 1.42190005552431 0.0922959093682965 no 389 0.0775276335450969 100 676306
SGTC_908 3448-7491 47.7 µM 1.42048366310523 0.0925124781816031 no 390 0.0777334607014013 103 1203031
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.42040561412618 0.0925244229234863 no 391 0.0777448146610131 97 6710655
SGTC_860 0443-0016 25.1 µM 1.41985655036293 0.092608484777131 no 392 0.0778247237749704 136 5337942
SGTC_1478 0453-0656 35.7 µM 1.41966776381254 0.092637401111601 no 393 0.0778522136069685 115 5258496
SGTC_194 1486-1323 56.904 µM 1.41460871591766 0.0934147821100432 no 394 0.0785916259414482 124 5178754
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.41353662413079 0.0935801383701363 no 395 0.078749000347247 101 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1292 0kpi-0043 232 µM 1.40974570728789 0.0941665715944751 no 396 0.0793073915800453 106 3333905
SGTC_1964 st076914 61 µM 1.40425145605432 0.0950213063393188 no 397 0.080121992063651 135 24208661
SGTC_1546 5-methoxyflavanone 78.7 µM 1.40415173803214 0.0950368719927647 no 398 0.0801368348923001 94 147795
SGTC_583 1488-1091 88.9 µM 1.40248999253798 0.0952965414679686 no 399 0.0803844884152044 132 4303273
SGTC_2891 9063876 19.48 µM 1.39701430813364 0.0961558850647352 no 400 0.0812046342537221 81 6472478
SGTC_1219 1469-0211 33.1 µM 1.39701128804428 0.0961563605986138 no 401 0.0812050883370804 111 6822282
SGTC_615 k087-0205 167 µM 1.39570851178453 0.0963616529587569 no 402 0.0814011450364057 112 9642773
SGTC_2457 5731572 11.68 µM 1.39371125385651 0.0966770073464936 no 403 0.0817024082294267 122 2865357
SGTC_3349 9149703 23.001 µM 1.39167087323894 0.0969999525992955 no 404 0.0820110431455675 85 4910494
SGTC_3333 9141820 12.094 µM 1.39160104584518 0.097011018664684 no 405 0.0820216209992307 108 1939433
SGTC_1248 0469-0687 58.6 µM 1.38603446816761 0.0978961797472467 no 406 0.0828681894050204 115 4017482
SGTC_1118 chelidonine 707.474 nM 1.3850284581753 0.0980567784987466 no 407 0.0830218828607126 91 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2867 9039098 71.43 µM 1.38473852104704 0.0981030996804994 no 408 0.0830662178606088 118 6463460
SGTC_1043 0916-0009 19.3 µM 1.38165201728414 0.0985972023727615 no 409 0.083539286983001 121 3101130
SGTC_812 4251-0442 148 µM 1.37923845955342 0.0989848439442653 no 410 0.0839106218764507 117 5723007
SGTC_695 3505-6186 243 µM 1.37709801816498 0.0993295520527917 no 411 0.0842409726810945 130 1819379
SGTC_3036 9090181 49.47 µM 1.37614196875843 0.0994838025793936 no 412 0.0843888421310942 109 25236586
SGTC_1729 st035615 45.989 µM 1.36958994976259 0.100545629148245 no 413 0.0854074693165067 117 17385451
SGTC_455 paf C-16 10 µM 1.36943472202598 0.100570885382301 no 414 0.0854317134035799 109 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2204 7233102 200 µM 1.36629244034087 0.101083143887734 no 415 0.0859235964133129 103 2172480
SGTC_2284 7945075 39.21 µM 1.3654940141585 0.101213606745424 no 416 0.0860489165872056 115 1245402
SGTC_109 0132-0036 33.701 µM 1.36525130879171 0.101253289115378 no 417 0.0860870384689754 103 67274 A color developer.
SGTC_2502 avocadyne acetate 18.59 µM 1.36518470810039 0.101264180321993 no 418 0.086097501689694 104 3952079
SGTC_2981 9013952 38.96 µM 1.36486480336067 0.101316506219791 no 419 0.0861477731960057 101 2996344
SGTC_1402 3909-7673 35.9 µM 1.36079418266973 0.101984046730886 no 420 0.0867893704110495 97 5328014
SGTC_2770 toltrazuril 17.5 µM 1.35532848466374 0.102885391710675 no 421 0.0876564617659336 100 68591 Kills coccidiodes.
SGTC_1959 st077091 55.8 µM 1.35044585770345 0.103695465234714 no 422 0.08843650481411 151 821356 YKL052C ASK1
SGTC_765 1319-0117 244 µM 1.35006780560964 0.103758380096203 no 423 0.0884971170458389 111 3487746 YGL099W LSG1
SGTC_92 0063-0024 660.874 µM 1.34974239931561 0.103812555894853 no 424 0.0885493134765113 103 3594437
SGTC_1009 4106-0057 9.87 µM 1.34498379810606 0.104607144524217 no 425 0.0893152333930968 144 2928005
SGTC_3112 9123419 49.47 µM 1.34416866733688 0.104743695392451 no 426 0.0894469255981326 125 17015854
SGTC_2435 5706476 10.6 µM 1.3430416293335 0.104932709583671 no 427 0.0896292472319937 105 5725375
SGTC_3272 9137413 49.47 µM 1.33019853345159 0.10710406896682 no 428 0.0917264336238552 122 17614870
SGTC_135 0933-0004 26.348 µM 1.32864568846118 0.1073687856673 no 429 0.0919824455358206 131 21230617 YGL099W LSG1
SGTC_1556 plumbagin 1.48 µM 1.32236471843061 0.108444327252128 no 430 0.0930233657267352 134 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2001 4023502 57.655 µM 1.31406534836045 0.109877354278651 no 431 0.0944121069798537 105 108941 YCR052W RSC6
SGTC_1614 st002383 48.6 µM 1.31147120798795 0.110328052100621 no 432 0.0948493074673083 97 1947235
SGTC_3075 9116269 49.47 µM 1.31027334449652 0.110536611958819 no 433 0.0950516907366337 109 17015205 YNL244C SUI1
SGTC_1609 st001574 46.4 µM 1.30796004810191 0.110940179270529 no 434 0.0954434302689825 133 3960012
SGTC_2636 apigenin dimethyl ether 100 µM 1.30653598589453 0.111189139024015 no 435 0.0956851748246792 126 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_813 k007-0158 173 µM 1.30549605068418 0.111371196843639 no 436 0.095861995532856 114 6523916
SGTC_2446 5162541 200 µM 1.30369750852083 0.111686564753769 no 437 0.0961683696282437 116 1549321
SGTC_3076 9116187 49.47 µM 1.3030838892414 0.111794306712771 no 438 0.0962730616056683 105 27241210
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.30246892912136 0.111902358665321 no 439 0.0963780663687562 126 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3240 9133527 49.47 µM 1.30173461922187 0.112031478849015 no 440 0.0965035603894014 110 17617455
SGTC_2249 haloperidol 116.36 µM 1.29953991846097 0.112418027265243 no 441 0.0968793516914919 161 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2471 5466956 24.79 µM 1.29807225140934 0.112677055741939 no 442 0.0971312542360329 148 724419
SGTC_1119 parthenolide 318.541 nM 1.29664626170587 0.112929136548392 no 443 0.0973764635981199 144 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2617 dihydrotanshinone i 20.83 µM 1.2951404360056 0.113195767158315 no 444 0.0976358939855181 144 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_442 cape 100 µM 1.29250768979652 0.113663015654793 no 445 0.0980906923086964 115 5281787
SGTC_2737 bleomycin 30.5 nM 1.29196217945338 0.113760002200878 no 446 0.0981851212566226 138 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1258 0671-0043 57.1 µM 1.29128192862388 0.113881026941624 no 447 0.0983029673301769 142 4298767
SGTC_3152 9099253 49.47 µM 1.28801228581598 0.114464015730163 no 448 0.0988708432571833 162 25236131
SGTC_834 0312-0008 75.7 µM 1.28479371543303 0.115039970062476 no 449 0.0994321895365848 124 6385573 YIL048W NEO1
SGTC_1865 st057639 52.2 µM 1.28479028933254 0.115040584249814 no 450 0.0994327883165741 139 688818
SGTC_527 4476-4215 268 µM 1.28343497043364 0.115283731374899 no 451 0.0996698643601678 100 4418754
SGTC_819 1013-0258 27.7 µM 1.28103645292664 0.115714925395149 no 452 0.100090431246721 125 5753198
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.27846292339422 0.116178854833066 no 453 0.100543124886687 175 16725076
SGTC_1100 amiodarone 5.07 µM 1.27745189134808 0.116361473965549 no 454 0.100721377343511 96 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2064 5220758 200 µM 1.27683649246593 0.116472730939237 no 455 0.100829989515237 147 788518
SGTC_3030 9087619 49.47 µM 1.2735184575273 0.117073893304786 no 456 0.101417063563215 143 25236973
SGTC_1608 st001473 40.5 µM 1.27124051645821 0.117487881953315 no 457 0.101821548337616 161 7292267
SGTC_865 0488-0499 301 µM 1.27019372228479 0.117678471511111 no 458 0.102007816636353 117 9634651
SGTC_910 3454-3003 490 µM 1.2699462496247 0.117723560761672 no 459 0.102051888549761 157 820824
SGTC_3195 9113082 49.47 µM 1.26779156156744 0.118116659313713 no 460 0.102436198225206 114 17018038
SGTC_1827 berberine 7.24 µM 1.26637060028597 0.118376405122209 no 461 0.102690215725961 105 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_916 4466-0038 42 nM 1.26623730323654 0.118400791967478 no 462 0.102714067979724 168 5722064 YGL116W CDC20
SGTC_2693 st077581 40.7 µM 1.26373518277712 0.118859216827192 no 463 0.103162546308496 131 25238761
SGTC_413 propylparaben 100 µM 1.26217933029569 0.119144902968732 no 464 0.103442132299348 133 7175 A pharmaceutical preservative.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.25930871476408 0.119673277855937 no 465 0.103959423352057 145 5024745
SGTC_1853 st056710 91.2 µM 1.25879159477779 0.119768636045013 no 466 0.104052808541051 138 269167
SGTC_271 rotenone 740 µM 1.25630227540317 0.120228422341189 no 467 0.104503198633117 115 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1846 st056244 14.8 µM 1.25510364756263 0.120450256254601 no 468 0.10472056825972 113 5393182
SGTC_1913 st060213 96.1 µM 1.25384102941957 0.120684244652644 no 469 0.104949896379689 141 688959
SGTC_506 n9-isopropylolomoucine 153 µM 1.25106256374582 0.121200276304988 no 470 0.105455826236476 107 6610355
SGTC_1387 3342-1166 1.8 µM 1.25047627196326 0.12130936357339 no 471 0.10556280892102 109 3418228
SGTC_3113 9123498 49.47 µM 1.24978265941327 0.121438508411009 no 472 0.10568947611878 142 8897275
SGTC_1552 6-methylflavone 10.6 µM 1.24813551338573 0.121745580404792 no 473 0.105990717393057 122 689013
SGTC_2402 5553605 200 µM 1.24806965440852 0.121757869609408 no 474 0.106002775017382 122 6758546
SGTC_3180 9109287 49.47 µM 1.24466318815328 0.122394700842567 no 475 0.106627791393076 139 18891271
SGTC_3024 9090631 49.47 µM 1.24385019101339 0.122547033744656 no 476 0.106777352001572 103 25236383
SGTC_1164 k060-0068 93.7 µM 1.24361265255845 0.122591566901182 no 477 0.106821078621539 130 5963676
SGTC_2388 9080168 200 µM 1.23991914638945 0.123285477926672 no 478 0.107502650671061 136 15943073
SGTC_1407 3909-7909 12.3 µM 1.23847024448389 0.123558437995784 no 479 0.107770874283947 130 4411780
SGTC_126 0417-1624 672.48 µM 1.23485291874005 0.124241756135783 no 480 0.108442624190706 180 41912 YDL195W SEC31
SGTC_706 4262-0057 46.9 µM 1.23414252968941 0.124376259602921 no 481 0.108574899038866 128 883298
SGTC_2184 6075246 200 µM 1.23386234064902 0.124429337958245 no 482 0.108627102300853 125 2267320
SGTC_1633 st005664 67.9 µM 1.23310033520779 0.124573770589581 no 483 0.108769166217034 121 2063822
SGTC_2824 7998404 51.95 µM 1.23205434907971 0.124772220502196 no 484 0.108964391350061 141 837851
SGTC_807 1315-0151 48 µM 1.23073124611493 0.125023562781452 no 485 0.109211698820307 173 4011080
SGTC_1291 0993-0025 5.79 µM 1.22961690879086 0.125235521231114 no 486 0.109420297568585 131 4353356
SGTC_1032 k061-1018 98.7 µM 1.22545897948438 0.126028616413227 no 487 0.110201168281909 123 4005393
SGTC_1499 4480-0877 67.3 µM 1.22430119873169 0.126250076737919 no 488 0.110419312454392 121 2861909
SGTC_901 1112-0062 60.1 µM 1.22237598797689 0.126618931271885 no 489 0.110782737694949 129 1908457
SGTC_2642 cholecalciferol 100 µM 1.21950858477053 0.127169692422789 no 490 0.111325609765463 113 9821465 A vitamin D precursor, similar to steriods.
SGTC_1651 st011928 86.1 µM 1.21493389536643 0.128051830298085 no 491 0.112195652385261 134 720198
SGTC_3089 9117425 49.47 µM 1.21445648015688 0.128144134681724 no 492 0.112286729434596 120 9401657
SGTC_14 0354-0009 295 µM 1.21241308832921 0.128539730164335 no 493 0.112677146641236 147 1713507
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.210658132954 0.128880161006977 no 494 0.113013227226146 123 641818 YHR062C RPP1
SGTC_1403 3909-7815 62.9 µM 1.21063774119857 0.128884120325149 no 495 0.11301713652457 132 6615483
SGTC_136 0097-0015 404.482 µM 1.20997834053045 0.129012196810426 no 496 0.113143602087612 145 4861337
SGTC_2212 7123476 200 µM 1.2078806548453 0.129420220633469 no 497 0.113546585841229 111 1085715
SGTC_3130 9127414 49.47 µM 1.20745945086558 0.129502257300471 no 498 0.113627626032542 136 1494646
SGTC_1931 st074438 57.1 µM 1.20509391643737 0.129963654831523 no 499 0.11408352403397 180 2787313
SGTC_982 1491-0518 27.5 µM 1.204248623435 0.130128804886768 no 500 0.114246748829037 122 3091256
SGTC_1404 3909-7820 48.3 µM 1.20302861196957 0.13036742195746 no 501 0.114482624316238 147 23741373
SGTC_1916 st067606 49.2 µM 1.20291559219277 0.130389542343215 no 502 0.114504492949678 161 19590279
SGTC_2857 9024691 58.44 µM 1.19848597686583 0.131258558155519 no 503 0.115363939526289 149 16478292
SGTC_2898 9056270 58.44 µM 1.19496394510189 0.131952369827404 no 504 0.116050558614549 99 19154699
SGTC_2596 sinensetin 100 µM 1.19465791412418 0.132012774667094 no 505 0.116110355957092 138 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2150 5556613 200 µM 1.19083897100828 0.132768167196556 no 506 0.116858403317555 142 743190
SGTC_522 1273-0010 11.6 µM 1.1906175201181 0.132812061636545 no 507 0.116901885247161 154 5705015
SGTC_3021 9087658 49.47 µM 1.18856420090575 0.133219532065446 no 508 0.117305601070446 122 25237042
SGTC_2902 5787006 60.46 µM 1.188499107334 0.133232463595844 no 509 0.117318415649619 141 591003
SGTC_482 fipronil 114 µM 1.18358585817516 0.134211026563909 no 510 0.118288520574367 113 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1137 ixabepilone 100 µM 1.18195295362896 0.134537339478124 no 511 0.118612184404419 144 154225 A novel microtubule stabilizer.
SGTC_418 lividomycin a 100 µM 1.17955154981088 0.135018214811189 no 512 0.11908931125567 138 72394 An antibiotic.
SGTC_1461 k072-0203 53.8 µM 1.17884284101156 0.135160357049304 no 513 0.119230380827231 126 5418714
SGTC_521 r062-0005 13.8 µM 1.1785398169772 0.135221164392413 no 514 0.119290734208128 128 2832033
SGTC_172 1112-0046 2.638 µM 1.17847294298731 0.135234586413718 no 515 0.119304056422875 133 2802135 YIL048W NEO1
SGTC_2181 6316240 54.2555 µM 1.17335965512252 0.13626356030269 no 516 0.120325804465428 129 12779990
SGTC_1179 1021-1431 9.29 µM 1.16786037202219 0.13737617499642 no 517 0.121431545544365 172 2840958
SGTC_251 melphalan 456.522 µM 1.16740232861531 0.137469125383965 no 518 0.121523965593706 169 460612 A DNA alkylator.
SGTC_2421 5690543 90.72 µM 1.16553625881499 0.137848249191111 no 519 0.12190099606113 163 3397993
SGTC_918 glabranin 770.725 nM 1.16403612585676 0.138153543475236 no 520 0.122204685952111 136 124049 Also referred to as licorice root.
SGTC_301 4119-0100 24.5 µM 1.16364684074998 0.138232842749819 no 521 0.12228358032986 146 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1984 st072354 53.1 µM 1.16226022549715 0.138515555131705 no 522 0.122564888855081 149 5762938
SGTC_1904 st060225 78 µM 1.16114399867864 0.138743424959999 no 523 0.122791672158488 143 66595
SGTC_2676 harmalol 100 µM 1.15661118252222 0.139671390096333 no 524 0.123715625726069 144 5459187 A monoamine oxidase inhibitor
SGTC_975 1335-0046 28.5 µM 1.15644824639591 0.139704825021075 no 525 0.123748928451481 147 16486740
SGTC_1485 3909-9022 254 µM 1.15505178702125 0.139991605359078 no 526 0.124034610003974 153 714516
SGTC_3344 9148862 3.898 µM 1.15504168794703 0.139993680785749 no 527 0.124036677707828 148 4905352
SGTC_249 wiskostatin 11.211 µM 1.15312966116457 0.140386991695924 no 528 0.124428584386299 142 2775510 A n-wasp and actin depolymerizer.
SGTC_2974 9094440 9.66 µM 1.15168923058409 0.140683788633194 no 529 0.124724399632669 147 25236134
SGTC_1251 0490-5699 265 µM 1.1516064796429 0.140700852172077 no 530 0.124741408766158 155 3883818
SGTC_2011 4012611 177 µM 1.15039285805583 0.140951266616578 no 531 0.12499105018994 129 2049887
SGTC_2587 piperic acid 92.2 µM 1.14988837891075 0.141055447979443 no 532 0.12509492394314 124 5370536
SGTC_1283 0922-0125 16.4 µM 1.14799624986674 0.141446661870573 no 533 0.125485055983172 142 3360884
SGTC_2751 anetholtrithion 17.25 µM 1.14522969636472 0.142019992906915 no 534 0.126057009951678 136 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2089 5281248 129.67 µM 1.1444669903675 0.142178329725585 no 535 0.126215009984688 149 2737878
SGTC_3350 9150499 3.57 µM 1.14352664867373 0.142373707877278 no 536 0.126409998454931 147 4910996 YPR165W RHO1
SGTC_2651 TUB2.036 5 µM 1.14321462056357 0.14243857918699 no 537 0.126474746696593 165 15992207 YFL037W TUB2
SGTC_1920 st075728 45.7 µM 1.14305975057547 0.142470784411152 no 538 0.126506891992826 139 3400306
SGTC_473 2-arachidonoylglycerol 10 µM 1.14156650237682 0.142781558146228 no 539 0.126817127242918 162 5282280 An endocannabinoid.
SGTC_1335 1486-0900 202 µM 1.1394433123109 0.143224223382988 no 540 0.127259149743108 137 X1335
SGTC_1933 st074711 15.9 µM 1.13876020289917 0.143366842177546 no 541 0.127401592484633 163 17250958
SGTC_1105 epirubicin 18.1 µM 1.13808455682953 0.143507997082106 no 542 0.127542588000603 162 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1711 st032263 62.8 µM 1.13365131489815 0.144436509893874 no 543 0.12847041948752 153 3958979
SGTC_848 0368-0089 85.6 µM 1.13235182333137 0.144709445249908 no 544 0.128743275321057 153 762535
SGTC_2462 5162487 171.77 µM 1.131645497882 0.144857942118294 no 545 0.128891751880447 151 2259986
SGTC_951 1171-0579 82.7 µM 1.12838178193594 0.145545433248628 no 546 0.129579359161463 162 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1770 st043884 66.3 µM 1.1270698090809 0.145822413338118 no 547 0.129856483430673 188 670149
SGTC_629 3448-6466 76.7 µM 1.12441924601773 0.146383073132998 no 548 0.130417605541093 171 573744
SGTC_2034 5197015 53.07 µM 1.12087737361739 0.147134523285408 no 549 0.131170031638258 157 780676
SGTC_2442 5158906 48.48 µM 1.11969488746642 0.147385976557602 no 550 0.131421902218004 164 1893835
SGTC_553 k007-0256 45.7 µM 1.11818253750762 0.147707994138279 no 551 0.131744520409339 163 6287000
SGTC_1488 4013-0813 75.9 µM 1.11781515075396 0.147786291155527 no 552 0.131822974677067 151 2910057
SGTC_36 0335-0881 14.2 µM 1.1169510958544 0.147970547007683 no 553 0.132007617867124 170 23828853
SGTC_2659 sanguinarine 24.21 µM 1.1126148460597 0.148897554413673 no 554 0.132936940781326 152 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_965 1291-5240 308 µM 1.11054439470357 0.149341543231273 no 555 0.133382254398477 156 2834598
SGTC_1691 st019933 84.6 µM 1.11053711564189 0.149343105715117 no 556 0.133383821790406 175 6176082
SGTC_2759 disulfiram 3.38 µM 1.11047052634573 0.149357399918335 no 557 0.133398160974622 173 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_810 3825-7150 143 µM 1.11005687008774 0.149446216730753 no 558 0.133487260504925 119 22330411 YGL099W LSG1
SGTC_480 am 92016 50 µM 1.10997916612489 0.149462904608168 no 559 0.133504002123084 192 2129 K+ channel blocker.
SGTC_38 0929-0051 58.268 µM 1.09948933815868 0.151727143273963 no 560 0.135777340987038 162 1379719
SGTC_1572 epiandrosterone 68.9 µM 1.091733540252 0.153415822297623 no 561 0.137475119155932 147 441302 A steroid.
SGTC_1985 st071382 65.5 µM 1.09117424744814 0.153538077193163 no 562 0.137598108633501 171 6123237
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.08821109835471 0.154186863229277 no 563 0.13825096316791 144 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.08799347430688 0.154234583720754 no 564 0.138298994194875 157 6708784 An antioxidant flavonoid
SGTC_721 1187-1332 279 µM 1.08744204162533 0.154355545329338 no 565 0.13842074985804 161 25730
SGTC_2522 biochanin a 4.94 µM 1.08636209116019 0.154592623630561 no 566 0.13865941318335 149 5280373 A possible chelator.
SGTC_175 3793-3120 23.7 µM 1.08348440913793 0.155225526978862 no 567 0.139296733699572 177 5322297
SGTC_698 k064-0052 127 µM 1.08337309644122 0.155250042860944 no 568 0.139321426108461 172 5088751
SGTC_2639 lactacystin 53 µM 1.08242725821566 0.155458460563629 no 569 0.139531360827718 155 3870 A proteasome inhibitor.
SGTC_1494 4358-1428 177 µM 1.08126554592076 0.155714699128319 no 570 0.139789504414893 150 1564571
SGTC_3085 9117376 49.47 µM 1.07745521772785 0.156557096053805 no 571 0.140638473484404 181 16480349
SGTC_1386 3228-0095 33.8 µM 1.0740030473943 0.157322896369635 no 572 0.141410657864598 155 870181
SGTC_679 0422-0091 41.4 µM 1.07203741097282 0.157760034970969 no 573 0.141851614542922 190 627384 YHR062C RPP1
SGTC_96 0929-0093 37.281 µM 1.06876832850883 0.158488812516867 no 574 0.142587036931432 187 6991579
SGTC_1670 st016595 4.04 µM 1.06807838099703 0.158642904472326 no 575 0.142742578460193 187 597879
SGTC_1325 1431-0015 227 µM 1.06803222639218 0.15865321608447 no 576 0.142752987630074 145 1103340
SGTC_2389 9091542 195.52 µM 1.06504318925837 0.159321946370145 no 577 0.14342819290968 176 3626624 YOL127W RPL25
SGTC_550 4123-0385 25.7 µM 1.06473773739892 0.15939038819718 no 578 0.143497313855249 161 5731123
SGTC_681 1642-0006 26.6 µM 1.06453845681544 0.159435050869206 no 579 0.143542421337079 190 4446530
SGTC_2407 paclitaxel 400 µM 1.06398164023615 0.159559887768055 no 580 0.143668508397953 162 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1326 1431-2094 10.8 µM 1.06371993017159 0.15961858461223 no 581 0.143727796549915 174 616278
SGTC_3317 9138495 8.753 µM 1.06341444477209 0.159687117345952 no 582 0.143797022505397 179 17020139
SGTC_190 3970-0790 3.722 µM 1.06236565595152 0.159922549609303 no 583 0.144034859398656 157 2832352
SGTC_2788 5282734 71.43 µM 1.06196349987582 0.160012885847599 no 584 0.14412612782765 171 743706
SGTC_2351 9026858 72.31 µM 1.05819336038181 0.160861393964526 no 585 0.144983648839115 178 1409300
SGTC_3275 9138069 49.47 µM 1.05534416055075 0.161504580450904 no 586 0.145633975552477 197 17617007
SGTC_1358 1509-0022 2.48 µM 1.05367613119647 0.16188190324646 no 587 0.146015610240569 186 3258434
SGTC_2591 skatole 100 µM 1.05256650208456 0.162133228896056 no 588 0.146269858279988 168 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2749 bexarotene 57.39 µM 1.05249906767486 0.16214851065071 no 589 0.146285319025322 165 82146 An retinoic acid receptor inhibitor.
SGTC_2363 9053361 176 µM 1.05159911156307 0.162352545399683 no 590 0.146491757788976 174 6469797 YMR079W SEC14
SGTC_2766 oltipraz 83.91 µM 1.05095596927389 0.162498458603509 no 591 0.146639406403471 184 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2114 5491910 81.25 µM 1.04943592391627 0.162843658669934 no 592 0.146988765795003 165 2849228
SGTC_1803 st050068 52.4 µM 1.04731763001571 0.163325514820522 no 593 0.147476553768972 182 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_200 k038-0079 37.545 µM 1.03913263556435 0.165196080514859 no 594 0.149371527369658 190 3436683
SGTC_3000 9075062 71.4286 µM 1.0384445412798 0.165353964199952 no 595 0.149531571000797 160 17057871
SGTC_2566 crystal violet carbinol 226 nM 1.03716273820991 0.165648335004699 no 596 0.149830010219239 211 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2329 6138490 200 µM 1.03705138180678 0.16567392440271 no 597 0.149855955814 172 720019
SGTC_732 3970-1727 52.7 µM 1.03348307586683 0.166495264515772 no 598 0.150688943303002 193 1275699
SGTC_1379 2144-0755 36.5 µM 1.03251782438467 0.166717893639542 no 599 0.15091480100755 189 5392327
SGTC_1486 3970-0793 4.53 µM 1.03036124679847 0.167215988224019 no 600 0.1514202289669 197 2844330
SGTC_2923 7992654 58.14 µM 1.02917600062504 0.167490147021042 no 601 0.151698488857271 174 2985126
SGTC_490 phenamil 164 µM 1.02900165538892 0.167530499163228 no 602 0.151739448489748 177 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1492 4158-0558 28.5 µM 1.02812598883484 0.167733266585574 no 603 0.151945283530101 154 3967268
SGTC_164 4100-3994 89.624 µM 1.02387181972601 0.168720600354656 no 604 0.152947911075673 199 4615967
SGTC_1988 st071872 53.4 µM 1.02361721147262 0.168779809628442 no 605 0.153008056246458 152 16414116
SGTC_1066 ketoconazole 628 nM 1.02256340368052 0.1690250151213 no 606 0.153257160110028 192 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_956 1185-0240 191 µM 1.02223651998844 0.1691011225941 no 607 0.15333448493476 173 1416193
SGTC_1955 wogonin 32.4 µM 1.01959856985346 0.169716114814796 no 608 0.153959441775667 133 5281703 A flavanone.
SGTC_1530 rhein 70.4 µM 1.0195835448445 0.169719621737963 no 609 0.153963006171549 188 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1446 4239-0190 62 µM 1.01876420664862 0.16991093033593 no 610 0.154157461159056 174 1340085
SGTC_1559 coumarin 343 70.1 µM 1.01345904030705 0.171152986110478 no 611 0.155420475523275 164 108770 A hepatotoxic, DNA x-linker.
SGTC_1247 0448-0043 5.84 µM 1.01209479207312 0.171473322737783 no 612 0.155746366122334 175 3089013 YGL099W LSG1
SGTC_3298 9116858 71.43 µM 1.01202722795127 0.171489197297107 no 613 0.155762517491484 194 2506942
SGTC_2734 clemastine 41.6 µM 1.01200934274757 0.171493399680577 no 614 0.155766793178196 194 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2191 5911152 200 µM 1.00847323393814 0.172325551436947 no 615 0.156613665500635 163 2875902
SGTC_2224 6650123 117.647 µM 1.00808937750318 0.172416039037325 no 616 0.156705778353469 170 2908370
SGTC_1963 st076565 50.3 µM 1.00518876749249 0.173100787846519 no 617 0.157402981413518 191 4914280
SGTC_662 k832-1615 104 µM 1.00382268720989 0.173423878446803 no 618 0.157732043484904 177 5878478
SGTC_1184 1269-1718 139 µM 1.00249451626463 0.173738370921201 no 619 0.158052406867693 182 5403821
SGTC_2567 aureobasidin a 60 nM 1.00192972677541 0.173872215114092 no 620 0.158188767075996 208 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_149 3970-0822 46.1 µM 0.998352903418254 0.174721375135781 no 621 0.159054131309021 187 3114250 YBL034C STU1
SGTC_2800 7887935 81.82 µM 0.997563481247603 0.174909142915578 no 622 0.159245538383129 183 2961002
SGTC_622 1348-1566 26.3 µM 0.995471617765201 0.175407321466489 no 623 0.159753470808785 180 7340407
SGTC_333 3486-0131 40.1 µM 0.995445587537353 0.175413526241809 no 624 0.159759797965912 185 6744690
SGTC_419 nsc-638432 893 µM 0.995280554736936 0.17545286803032 no 625 0.159799916237842 183 368090
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.995032907158056 0.175511914658186 no 626 0.159860129925115 208 688798
SGTC_2783 7738165 71.43 µM 0.991870668261983 0.176266994398156 no 627 0.160630309576579 183 17201110
SGTC_66 0109-0187 42.4 µM 0.991220996356487 0.176422377304632 no 628 0.160788840135009 143 759417
SGTC_2654 protoveratrine a 100 µM 0.986378680584097 0.177583248955253 no 629 0.161973661428961 205 5702278 A heart drug and vasodilator.
SGTC_1766 st045414 44.774 µM 0.985561487935215 0.177779632839944 no 630 0.162174172172671 186 253960
SGTC_1047 2043-3044 82 µM 0.984284945381325 0.178086679570588 no 631 0.162487714750693 212 669592
SGTC_1294 1000-1494 117 µM 0.984158663594741 0.178117072285523 no 632 0.162518753332279 158 712797 YDL207W GLE1
SGTC_1417 3966-0327 90.4 µM 0.983838232310019 0.178194206367787 no 633 0.16259752889626 183 651118
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.982557278657317 0.17850276725053 no 634 0.162912689597689 203 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.981406477650516 0.178780263292465 no 635 0.163196166534115 186 279621
SGTC_601 0986-0029 62.9 µM 0.98071658391657 0.17894674953275 no 636 0.163366261716953 186 24747981
SGTC_1638 st008370 60.6 µM 0.979326771013006 0.179282437506222 no 637 0.163709273443503 185 24207134
SGTC_3111 9122088 49.47 µM 0.978644951284608 0.179447265291919 no 638 0.163877720265389 173 16876704
SGTC_1767 st044992 70.3 µM 0.978105698849141 0.179577695325449 no 639 0.164011024784655 192 9600693
SGTC_3139 9095020 49.47 µM 0.977184259609168 0.179800703468218 no 640 0.164238969574872 156 25236292
SGTC_2251 lansoprazole 556 µM 0.97680247634096 0.17989315419386 no 641 0.16433347493302 176 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_779 1360-0071 233 µM 0.973123129962109 0.180785656054596 no 642 0.165246054799087 203 7566
SGTC_1818 st052136 56.3 µM 0.972154064106999 0.181021184141551 no 643 0.165486954607898 201 674169
SGTC_3095 9117207 49.47 µM 0.971261223438293 0.181238356052097 no 644 0.165709106586271 148 17015229
SGTC_2391 6285546 200 µM 0.970053400879461 0.181532402776928 no 645 0.166009937432396 176 846083
SGTC_2508 celastrol 40.54 µM 0.969574499731523 0.181649074804385 no 646 0.166129314380934 155 122724 Celastrol is a natural product and antioxidant.
SGTC_2239 6685329 187.64 µM 0.969370420894175 0.181698807653213 no 647 0.16618020249688 161 805680
SGTC_2744 captopril 92.04 µM 0.968391534377116 0.181937475133478 no 648 0.166424432888696 127 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1237 0330-0133 46.1 µM 0.966164488918206 0.182481192802093 no 649 0.166980939559245 218 X1237 YHR072W ERG7
SGTC_2869 9037858 32.47 µM 0.965574202810094 0.182625477044308 no 650 0.167128644555727 195 27187042
SGTC_1910 st062352 60.4 µM 0.964638859542295 0.182854249794592 no 651 0.167362864299179 177 2245730
SGTC_1496 4469-0713 57.4 µM 0.963950296281243 0.183022777632277 no 652 0.167535422857137 183 746691
SGTC_1362 1611-0397 101 µM 0.962880614609474 0.18328477744241 no 653 0.167803719480929 193 27816
SGTC_3110 9122132 49.47 µM 0.958886540039993 0.184265121640614 no 654 0.16880795311396 164 918317
SGTC_276 colchicine 750 µM 0.956289005506813 0.184904433320131 no 655 0.169463121506101 200 2833 A microtubule depolymerizer.
SGTC_305 1682-2595 20.8 µM 0.955937714760352 0.184990999567012 no 656 0.169551851617446 203 226033
SGTC_699 0375-0592 111 µM 0.95496665691434 0.185230421885873 no 657 0.16979727947967 163 762578
SGTC_2624 nerol 100 µM 0.95310614869862 0.185689682777603 no 658 0.17026814554374 207 637566 A natural product oil.
SGTC_2259 7964009 200 µM 0.952273065776974 0.185895555592404 no 659 0.170479256932556 164 313134
SGTC_1992 st073643 23.3 µM 0.949096595740201 0.186681828058393 no 660 0.171285742829374 202 3161292
SGTC_556 4058-0063 51.5 µM 0.945452676948639 0.187586339707656 no 661 0.172213909913633 194 6615692
SGTC_3258 9138477 49.47 µM 0.94331622205993 0.188117918243863 no 662 0.172759590387793 206 4970355
SGTC_2060 5238662 140 µM 0.942746704000079 0.188259778747453 no 663 0.172905239121505 200 790130
SGTC_1264 0783-0040 158 µM 0.941626710434406 0.188538948937759 no 664 0.173191894804478 190 2855798
SGTC_41 0478-0632 82.643 µM 0.941538975107709 0.188560828668057 no 665 0.173214362914537 204 3750424
SGTC_2190 6049624 200 µM 0.93905860717385 0.189180038781817 no 666 0.173850327397493 197 2265554
SGTC_2496 diffractaic acid 79.83 µM 0.937185998906245 0.189648353543508 no 667 0.1743314452497 193 94870 An apoptosis inducer which activates caspases.
SGTC_308 4092-1169 104 µM 0.936702100478468 0.189769486045297 no 668 0.174455907743289 209 2268590 YDL196W YDL196W
SGTC_2694 st077685 81.9 µM 0.930990695077632 0.191202793614829 no 669 0.175929188717198 179 2838096
SGTC_1630 st005209 31.3 µM 0.930568215982906 0.191309079963307 no 670 0.176038481048852 209 3367314
SGTC_1669 st015249 58.4 µM 0.926197509860614 0.192410776508727 no 671 0.177171673204771 203 722793
SGTC_3010 9080089 71.4286 µM 0.925316143298222 0.192633406163291 no 672 0.17740074196602 191 17027233
SGTC_1128 3448-9350 235 µM 0.92403804155844 0.192956529071218 no 673 0.177733254925315 168 619386
SGTC_2359 9039622 200 µM 0.922991484408612 0.193221360441845 no 674 0.178005821488323 218 6463596
SGTC_2017 5132927 60.65 µM 0.921934920388975 0.19348894897828 no 675 0.178281261458611 171 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1596 piperlongumine 63 µM 0.921504522095181 0.193598017693259 no 676 0.178393540687978 179 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1714 st033236 13.627 µM 0.916135885461099 0.194961651121043 no 677 0.179797814047171 203 2916566
SGTC_3295 9122362 53.5725 µM 0.913030021673386 0.195753200195541 no 678 0.180613376139833 217 4730473
SGTC_884 0851-0618 334 µM 0.912469572471592 0.195896241697799 no 679 0.180760789995652 218 9642473
SGTC_99 0109-0120 622.8 µM 0.911737945904791 0.196083067612374 no 680 0.180953341766767 206 759414
SGTC_714 4296-0578 26.1 µM 0.911731352458837 0.19608475178569 no 681 0.180955077634721 221 1589775
SGTC_3052 9092717 49.47 µM 0.911529657726928 0.196136275198195 no 682 0.181008183198593 218 25237534
SGTC_1990 st072050 59.8 µM 0.910849170834867 0.19631016780862 no 683 0.181187425216657 205 17233948
SGTC_472 calcifediol 10 µM 0.90949117900049 0.196657470263724 no 684 0.181545455966124 184 5283731 A vitamin D metabolite.
SGTC_3142 9086498 49.47 µM 0.909315091056661 0.196702531486121 no 685 0.181591913469399 220 25236367
SGTC_947 3447-0010 211 µM 0.907787149794059 0.197093796919457 no 686 0.181995344444999 214 748350
SGTC_1788 fluconazole 20 µM 0.904682547945558 0.197890252886891 no 687 0.18281679467501 214 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2293 7624732 200 µM 0.903759023232632 0.198127549018725 no 688 0.183061597087399 193 894453
SGTC_438 sphingosine 6.67 µM 0.90365045516926 0.198155456447187 no 689 0.183090389089029 182 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_905 2-aminofluorene 215 µM 0.902783949469042 0.198378276845844 no 690 0.183320285654246 212 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1015 4130-4525 82 µM 0.901755464138452 0.198642946156856 no 691 0.183593391270411 209 1363237
SGTC_889 0919-1524 82.7 µM 0.900261983584145 0.199027655757816 no 692 0.183990423597745 188 3905452
SGTC_2156 5649887 115 µM 0.898641998336519 0.199445459232326 no 693 0.184421690355292 213 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2047 4141938 200 µM 0.89782824949861 0.199655528788524 no 694 0.18463856078086 236 3807862
SGTC_552 k242-0005 476 µM 0.897312546477684 0.199788726603171 no 695 0.184776081723267 235 4088318
SGTC_1937 st074714 47.2 µM 0.896976296789143 0.19987560328294 no 696 0.184865782678113 183 17250970
SGTC_3303 9125618 40.5795 µM 0.896179064510793 0.200081674598104 no 697 0.185078567572527 203 22695467
SGTC_2378 9074213 121.43 µM 0.895467569144641 0.200265692152333 no 698 0.18526859732652 226 657714
SGTC_2860 9025725 38.96 µM 0.892775056551727 0.200962990028954 no 699 0.185988823311812 206 40546248
SGTC_2893 9048488 25.97 µM 0.892307814828009 0.20108414286732 no 700 0.186113983333385 206 6467338
SGTC_1625 st003711 30.1 µM 0.891071600156779 0.201404896757988 no 701 0.186445379816154 206 24207034 YER133W GLC7
SGTC_205 1486-1330 71.903 µM 0.890046256317276 0.2016711696454 no 702 0.186720524516923 210 4118834
SGTC_1214 0358-0031 63.7 µM 0.887858962756451 0.202239894998024 no 703 0.187308310728225 206 4301366
SGTC_469 w7 172 µM 0.887495690264147 0.202334443485119 no 704 0.187406042740842 197 45115570 A P450 inhibitor.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.885299022296528 0.202906730592238 no 705 0.187997688584123 194 2724 A muscle relaxant with antifungal properties.
SGTC_1710 st031758 61.5 µM 0.882677009575383 0.203591094942071 no 706 0.188705403615089 214 5394341
SGTC_3150 9097574 49.47 µM 0.881279839924556 0.203956327862853 no 707 0.18908318748869 190 17217476
SGTC_3218 9131285 49.47 µM 0.881239073349214 0.203966990477093 no 708 0.189094217444927 222 17156417
SGTC_560 2332-1943 155 µM 0.879784502381491 0.204347654982273 no 709 0.189488030852106 216 21177716
SGTC_1456 k015-0012 13 µM 0.879098556237349 0.204527315295486 no 710 0.189673920253032 232 2989616
SGTC_1222 0366-0074 1.18 µM 0.87741611297078 0.204968372041011 no 711 0.190130332206384 228 286520
SGTC_1147 3809-1045 12.3 µM 0.877042849995734 0.205066300455219 no 712 0.190231682105959 205 325925
SGTC_509 pifithrin 175 µM 0.875997295127119 0.205340757825825 no 713 0.190515752119881 233 4817 A p53 inhibitor.
SGTC_613 3914-0030 117 µM 0.874932271423948 0.205620549948407 no 714 0.190805379296138 188 1145395
SGTC_2991 9074669 71.4286 µM 0.873881093247553 0.205896926503331 no 715 0.191091506024762 237 17333109
SGTC_1693 xanthone 101.9 µM 0.873417091218543 0.206018992338014 no 716 0.19121788928291 248 7020 An insecticide.
SGTC_783 0848-0141 92.7 µM 0.870547956391599 0.206774733370759 no 717 0.192000511762002 246 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_485 niflumic acid 177 µM 0.870078322929229 0.206898592737545 no 718 0.192128801528633 214 4488 A COX2 inhibitor.
SGTC_2946 9065502 71.43 µM 0.868535709121887 0.207305744802679 no 719 0.192550566252707 170 16489101
SGTC_3185 9108267 49.47 µM 0.868374158948506 0.207348411175754 no 720 0.19259476826194 228 4910486
SGTC_2625 euphol 100 µM 0.86700298563971 0.207710755292654 no 721 0.192970186910816 227 6708538 A triterpene alcohol.
SGTC_2128 5255449 168.493 µM 0.866348001772306 0.20788397224146 no 722 0.193149675002129 206 736008
SGTC_836 0330-0104 1.35 µM 0.866156397776408 0.207934659931103 no 723 0.193202200343732 206 46494820
SGTC_755 1995-0008 37.3 µM 0.865619275201439 0.208076791386723 no 724 0.193349490857163 190 689533
SGTC_3126 9127922 49.47 µM 0.865290735682106 0.20816375659736 no 725 0.193439617192818 255 45595682
SGTC_2729 fluphenazine 10.66 µM 0.864978351291453 0.20824646539581 no 726 0.19352533555188 239 3372 An atypical antipsychotic.
SGTC_1615 st002656 86.5 µM 0.864678278709957 0.208325932699504 no 727 0.193607697360541 200 1584458
SGTC_1435 4092-0789 56.7 µM 0.864613135278818 0.208343186798062 no 728 0.193625580294343 229 2248285
SGTC_2440 5628896 157.78 µM 0.864184702873296 0.208456683782774 no 729 0.193743217069214 225 5522048
SGTC_484 loperamide 105 µM 0.863646790913113 0.208599234856471 no 730 0.193890975860981 176 3955 An opioid-receptor agonist.
SGTC_791 1348-1292 225 µM 0.861508246399813 0.209166534786355 no 731 0.194479090664442 224 5437054
SGTC_683 panaxydol 45 µM 0.860808101513882 0.209352462101096 no 732 0.194671871129506 193 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.860478168942512 0.209440111209611 no 733 0.194762756265456 232 7104
SGTC_311 1315-0136 58 µM 0.859926417907307 0.209586736322467 no 734 0.194914802460897 202 6759207
SGTC_1019 4262-0212 3.4 µM 0.859080840370068 0.209811561503731 no 735 0.195147958537197 229 4677213
SGTC_1157 4092-0394 27.6 µM 0.858209349737998 0.210043424845089 no 736 0.195388437081948 219 3659885
SGTC_1431 4049-0260 9.09 µM 0.857177552479963 0.210318132905187 no 737 0.195673383141714 244 3854841
SGTC_2164 5685496 200 µM 0.855426306827118 0.210784871128143 no 738 0.196157592586696 201 759046
SGTC_1453 4237-0541 195 µM 0.855093816587761 0.210873554282132 no 739 0.196249606250288 211 739892
SGTC_1657 st012939 43.4 µM 0.853982161362602 0.211170218324079 no 740 0.196557436730651 205 24207257
SGTC_3144 9087057 49.47 µM 0.852005803847606 0.211698246322996 no 741 0.197105435392939 205 17249618
SGTC_3187 9109394 49.47 µM 0.851989174418345 0.211702692521844 no 742 0.197110050271617 232 17098090
SGTC_447 ml7 120 µM 0.851723679493856 0.211773685114976 no 743 0.197183737353465 231 4216 Selective myosin light chain kinase inhibitor.
SGTC_369 0957-0393 4.5 µM 0.849754507388137 0.212300670854115 no 744 0.197730793478371 226 6997992
SGTC_1952 st077036 64.1 µM 0.849074658988038 0.212482788292566 no 745 0.197919875089477 205 2937007
SGTC_2708 st078559 56 µM 0.847489761031923 0.21290770414753 no 746 0.19836109587022 203 17250902
SGTC_2223 6903751 107.57 µM 0.846223029840142 0.213247674833661 no 747 0.198714168422823 225 5598863
SGTC_424 splitomicin 100 mM 0.845928981127395 0.213326638120469 no 748 0.198796181983317 221 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2076 5212012 200 µM 0.844528280544627 0.213703013549167 no 749 0.199187133490974 213 604802
SGTC_1481 3346-2004 36 µM 0.842430418769047 0.214267442661308 no 750 0.199773536106059 253 2770522
SGTC_2192 5915882 198.485 µM 0.841396248323942 0.214546004743235 no 751 0.200062993265608 206 2876149
SGTC_2424 5537928 59.2 µM 0.839046316130827 0.215179759905204 no 752 0.200721659708774 242 5382802
SGTC_1961 st076550 68.7 µM 0.838955490318247 0.215204276585662 no 753 0.200747143528586 242 1579337
SGTC_2265 7929201 200 µM 0.838917705707988 0.215214476291678 no 754 0.200757745670444 252 1265108
SGTC_1971 st069429 63.5 µM 0.838491615610326 0.21532951592046 no 755 0.200877327335961 215 1246522 YGL099W LSG1
SGTC_641 4092-0595 30 µM 0.838057390565642 0.215446788596312 no 756 0.200999236026833 218 786260
SGTC_2568 diosmetin 100 µM 0.837294856528211 0.215652818462536 no 757 0.201213424846809 249 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2093 5331342 194.4 µM 0.837032678495012 0.215723683000424 no 758 0.201287099857088 225 33839
SGTC_3097 9117246 49.47 µM 0.834618992353178 0.216376716166335 no 759 0.201966132605971 227 16423892
SGTC_2803 7707263 71.43 µM 0.832962936055308 0.216825430384495 no 760 0.202432816469482 198 2199229
SGTC_98 0074-0023 107.663 µM 0.832024392451023 0.217079970710914 no 761 0.202697588163235 207 3563821
SGTC_516 3992-2719 87.3 µM 0.831696508111402 0.217168936174439 no 762 0.202790136075804 197 5350887 YDR037W KRS1
SGTC_180 1486-1293 102.781 µM 0.829399550734063 0.217792764197883 no 763 0.203439177816954 223 4140536
SGTC_33 0986-0033 35.816 µM 0.828320375819031 0.218086212615432 no 764 0.203744543217108 197 2848082
SGTC_124 0136-0217 7.121 µM 0.827371686866074 0.218344367523644 no 765 0.204013211618637 240 3976905
SGTC_2519 cryptotanshinone 88.04 µM 0.826860851112651 0.218483447777179 no 766 0.204157967524899 223 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_830 4076-0286 57.8 µM 0.826838892896175 0.218489427269354 no 767 0.204164191211969 235 6866659
SGTC_2340 7987427 183.45 µM 0.82601437071016 0.218714022988472 no 768 0.20439796993012 219 2239331
SGTC_2875 9039966 71.43 µM 0.825992945512394 0.218719860875885 no 769 0.204404046790273 229 6463691
SGTC_2684 capsaicin 100 µM 0.824093814483839 0.219237687808152 no 770 0.20494312725044 237 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1607 st000305 50.6 µM 0.824082833376277 0.219240684021678 no 771 0.204946246763708 224 5457690
SGTC_768 0384-0033 77.3 µM 0.822980161962013 0.21954166958252 no 772 0.205259637402517 221 3965305 YMR134W ERG29
SGTC_2059 5238311 157 µM 0.822828880354354 0.219582981967948 no 773 0.205302655400779 241 703021
SGTC_2065 5221596 34.26 µM 0.821558701448867 0.219930021887031 no 774 0.205664050988818 222 788581
SGTC_3058 9093861 49.47 µM 0.820288194927796 0.220277465968949 no 775 0.2060259172598 227 17217477
SGTC_2415 st077333 57.7 µM 0.820043855538764 0.220344321268241 no 776 0.206095553387513 250 2766255
SGTC_1448 4255-0083 152 µM 0.819767441058009 0.22041996686415 no 777 0.206174347660059 247 5399660
SGTC_2897 9048598 12.99 µM 0.815239773457156 0.221661158232789 no 778 0.207467537665179 229 6467404
SGTC_2316 5844804 197.44 µM 0.814365061162297 0.221901406819359 no 779 0.207717923982104 234 776813
SGTC_658 3253-0951 102 µM 0.812306766716487 0.222467324504637 no 780 0.208307814367703 228 1184878
SGTC_79 0052-0007 94.094 µM 0.811835871437786 0.22259691038455 no 781 0.20844290788794 223 2801472
SGTC_1286 0929-0070 131 µM 0.810927578339871 0.222846985480531 no 782 0.20870363085765 235 1420408
SGTC_1188 1403-0014 4.57 µM 0.810491534214571 0.222967095837756 no 783 0.208828864347637 229 9614867
SGTC_707 0865-0008 204 µM 0.809773087700111 0.223165075636072 no 784 0.209035301401281 255 723043
SGTC_1023 4482-3888 16 µM 0.809261818956483 0.223306025109583 no 785 0.209182281556398 248 3303168
SGTC_347 4534-1311 26.2 µM 0.808918762209062 0.223400629339538 no 786 0.209280938024235 241 2862016
SGTC_2003 4023581 200 µM 0.808702063121985 0.22346039986252 no 787 0.209343270590363 217 16641307
SGTC_2116 5511452 16.8835 µM 0.806619445321668 0.22403529674325 no 788 0.20994288355985 236 870744
SGTC_2978 9011784 42.97 µM 0.803803703350513 0.224813903405151 no 789 0.210755175326721 214 2994934
SGTC_134 0269-0018 6.916 µM 0.801257288921665 0.225519355048557 no 790 0.211491355812814 234 4378915
SGTC_1181 1222-0449 220 µM 0.800092991651566 0.225842325696728 no 791 0.211828460689512 237 658318
SGTC_423 5-fluorouracil 457 µM 0.797977738128237 0.226429755961339 no 792 0.212441704503423 238 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1824 st053723 68.6 µM 0.797318921202975 0.226612893077017 no 793 0.212632917069445 238 675225
SGTC_396 dithiazanine 1.25 µM 0.790583060262748 0.228490109730535 no 794 0.214593667578255 215 10578 An antihelmenthic.
SGTC_72 0744-0168 198.391 µM 0.790318682278933 0.228563966954547 no 795 0.214670839448209 251 677577
SGTC_3170 9103054 49.47 µM 0.788824350348619 0.228981678866234 no 796 0.215107337694959 242 16432970
SGTC_2512 diallyl trisulfide 49.23 µM 0.786996165863973 0.229493294934139 no 797 0.215642055315283 280 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_624 k048-0052 28 µM 0.786109561920201 0.22974164085289 no 798 0.21590165145665 227 6835531
SGTC_3158 9100007 49.47 µM 0.783174244922489 0.230564923174022 no 799 0.216762398444684 243 19297233
SGTC_3162 9099653 49.47 µM 0.780505637860459 0.23131482871565 no 800 0.217546655168127 213 25237511
SGTC_1618 st003135 44.5 µM 0.780084836477759 0.231433202203897 no 801 0.217670470609721 266 1270615
SGTC_2187 6125751 200 µM 0.780045104330527 0.231444380796299 no 802 0.217682163387902 244 874498
SGTC_1529 apigenin 74 µM 0.779966685300838 0.231466444780572 no 803 0.217705242396651 244 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_588 3970-1144 52.9 µM 0.779196391952271 0.231683236903767 no 804 0.217932017588815 214 1888707
SGTC_1102 cgs 12066b 26.1 µM 0.776479529580125 0.232448775945378 no 805 0.21873295143331 228 6438352 A 5-HT1B full agonist.
SGTC_2347 9049783 174.81 µM 0.775757093489265 0.232652575605944 no 806 0.218946211118394 271 6467988 YPL169C MEX67
SGTC_678 1218-2179 85.9 µM 0.774012722590219 0.233145072895386 no 807 0.21946163382788 272 6820081 YOR116C RPO31
SGTC_790 1575-0012 79.1 µM 0.773468055444451 0.233298970088558 no 808 0.219622713521414 258 378741 YLR208W SEC13
SGTC_1875 nocodazole 6 µM 0.773042941823462 0.233419126266317 no 809 0.219748483655399 239 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1610 st001799 48.1 µM 0.769321719274101 0.234472374911042 no 810 0.220851173376404 239 621897
SGTC_2614 arthonioic acid 13.39 µM 0.766928798435609 0.235151049857859 no 811 0.22156192509551 239 6710684
SGTC_799 1310-0557 151 µM 0.766530862581464 0.235264016665793 no 812 0.221680247716443 252 5354492
SGTC_1434 4073-0095 163 µM 0.76607631813441 0.235393090283173 no 813 0.221815446554467 240 24133745
SGTC_1814 st052110 31.539 µM 0.766006855224251 0.235412818593111 no 814 0.221836111618649 256 674163
SGTC_3128 9127691 49.47 µM 0.765293963724152 0.235615341166364 no 815 0.222048258828191 246 41316314
SGTC_378 3970-0959 8.33 µM 0.765185029693872 0.235646296273868 no 816 0.222080686372517 251 6615653
SGTC_3047 9092122 49.47 µM 0.763290687561745 0.236184958246133 no 817 0.222645027299725 249 17173831
SGTC_1295 1013-0063 9.78 µM 0.760598826587194 0.236951562338338 no 818 0.223448360425339 249 6826038
SGTC_1004 4084-0029 199 µM 0.759977399188734 0.237128730230674 no 819 0.223634047254447 244 716894 YLR208W SEC13
SGTC_1885 st057546 99.9 µM 0.758748593741389 0.237479274721194 no 820 0.224001481050416 230 702008
SGTC_1641 st009299 47.1 µM 0.758247621805421 0.237622269857021 no 821 0.224151378569739 245 4046054
SGTC_1893 st059353 36.1 µM 0.757933587995259 0.237711930315064 no 822 0.224245370735724 268 3112488
SGTC_1784 st039334 36.3 µM 0.757209226431591 0.237918815078538 no 823 0.224462261731567 283 3496984
SGTC_3178 9107506 49.47 µM 0.756420225822459 0.238144273671615 no 824 0.22469864258352 239 8897194
SGTC_890 0929-0006 47.2 µM 0.755468129967785 0.238416492879078 no 825 0.224984073883035 234 1378169
SGTC_3096 9117468 49.47 µM 0.754598997790975 0.238665140153339 no 826 0.225244812601667 251 41316311
SGTC_338 4055-0136 114 µM 0.75413814393171 0.238797041923447 no 827 0.225383137669236 245 2900563
SGTC_269 exalamide 29 µM 0.753011625851197 0.239119632392661 no 828 0.225721463930624 245 3316 A derivative of salicylamide.
SGTC_2707 st078556 66.6 µM 0.752241980513581 0.239340165423625 no 829 0.225952775991536 242 17250899
SGTC_1067 clotrimazole 1.36 µM 0.750770505926878 0.239762108644178 no 830 0.226395391252781 242 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1433 4060-0023 7.6 µM 0.749920374421206 0.240006067487302 no 831 0.22665133133517 253 3840627
SGTC_2449 5812982 45.77 µM 0.748974974080519 0.240277524124555 no 832 0.226936144675923 248 776185
SGTC_680 0417-1641 114 µM 0.748798026418898 0.240328350404514 no 833 0.226989474725961 248 2835990
SGTC_2360 9040895 200 µM 0.748289047567326 0.240474581661581 no 834 0.227142914665235 239 4914414
SGTC_2441 5730946 39.09 µM 0.747853490404693 0.240599757096899 no 835 0.227274266856251 248 1774275
SGTC_2222 6885208 172.143 µM 0.74640653953061 0.241015853053969 no 836 0.227710935028095 237 609514
SGTC_1420 4'-methoxyflavone 42 µM 0.745615243359737 0.241243569478306 no 837 0.227949936008424 252 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2480 5767542 37.17 µM 0.745119153879021 0.241386391971898 no 838 0.228099845488679 257 2867358
SGTC_2722 naftopidil 47.16 µM 0.744033541163643 0.241699096408824 no 839 0.228428091807148 270 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2935 9038016 29.96 µM 0.743722754960641 0.241788657037548 no 840 0.228522110097451 249 6463195
SGTC_928 2764-0428 58.7 µM 0.743086096221771 0.241972182011853 no 841 0.228714778419035 265 662578
SGTC_811 0416-0114 265 µM 0.743078148274673 0.241974473586054 no 842 0.22871718423618 245 6612453
SGTC_850 0388-0143 75.9 µM 0.742044019285412 0.242272736914566 no 843 0.229030332811785 253 67273
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.741637414375236 0.242390064393038 no 844 0.22915352425773 228 6312947
SGTC_2648 atorvastatin 78.68 µM 0.739019493498023 0.243146212620173 no 845 0.229947580228802 254 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_712 r015-0009 80.6 µM 0.738047414205129 0.243427307910941 no 846 0.230242818578696 257 6813872 YLR060W FRS1
SGTC_1887 st057648 70.8 µM 0.737764976587322 0.243509013047398 no 847 0.230328639807081 270 688672
SGTC_1151 3909-8316 15.3 µM 0.737054639374887 0.243714568838422 no 848 0.230544561249521 259 800431
SGTC_1036 k216-0215 33.5 µM 0.735482704551639 0.244169784646504 no 849 0.231022784728312 223 622330
SGTC_2790 5423970 71.43 µM 0.735439418285064 0.244182326377414 no 850 0.231035961366085 254 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2266 7929956 200 µM 0.73418726504405 0.244545274638803 no 851 0.231417306967517 262 2967153
SGTC_1734 st037168 69.4 µM 0.731419292527846 0.245348627347687 no 852 0.232261542382883 244 708907
SGTC_1073 triclabendazole 3.09 µM 0.730589530785406 0.245589726358401 no 853 0.232514954308902 249 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2962 9082311 13.18 µM 0.72687927066423 0.246669349870389 no 854 0.233649958418935 271 16459453
SGTC_2931 9014674 55.67 µM 0.726401080854183 0.24680867975934 no 855 0.233796464397304 276 2996810
SGTC_1196 1588-0294 184 µM 0.725987601286737 0.246929189018654 no 856 0.233923185730967 258 6144269
SGTC_1769 st044406 64.4 µM 0.725709340979734 0.24701030613838 no 857 0.234008487099271 280 670903
SGTC_1205 4161-2785 76 µM 0.725440401952514 0.247088719509966 no 858 0.234090947378015 253 3498106
SGTC_2333 9017922 200 µM 0.725267521264534 0.247139132603315 no 859 0.234143963389589 274 3163164
SGTC_2104 5389443 200 µM 0.724343967714909 0.24740853978185 no 860 0.234427295161466 255 2244536
SGTC_263 alizarin 107.927 µM 0.724145238589229 0.247466531003897 no 861 0.234488286939174 274 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2028 5153890 36.43 µM 0.723792544092144 0.247569468801921 no 862 0.234596553703471 265 2830968 YPR165W RHO1
SGTC_1289 0976-0073 69.1 µM 0.72311905668386 0.247766097093987 no 863 0.234803371172053 258 3391136
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.720517477518498 0.248526424702824 no 864 0.235603221353777 260 16623 A steroid.
SGTC_2837 9008476 45.46 µM 0.71962457797606 0.248787666386085 no 865 0.23587808754129 266 2992805
SGTC_165 k038-0023 64.381 µM 0.719524500600549 0.248816955812717 no 866 0.235908905923893 263 46368543
SGTC_2099 5377090 177.372 µM 0.719127413534521 0.248933188506137 no 867 0.23603120899014 266 2243829
SGTC_817 1391-0715 46 µM 0.717644715559538 0.249367449301977 no 868 0.236488189534221 283 1353946
SGTC_774 k060-0086 136 µM 0.714001825033197 0.250436107086599 no 869 0.237613025466665 262 5911235
SGTC_2110 5483698 200 µM 0.713432291241967 0.25060340142715 no 870 0.237789148632587 253 2848765 YHR062C RPP1
SGTC_782 0083-0095 30.5 µM 0.712596086869983 0.250849134571213 no 871 0.238047866947562 268 3591729 An indicator and reagent.
SGTC_489 paxilline 115 µM 0.712346800964323 0.250922416227912 no 872 0.238125024860532 268 105008 A toxic potassium channel blocker.
SGTC_1757 st041620 31.8375 µM 0.711991428490055 0.251026903347399 no 873 0.238235041926941 277 5289815
SGTC_3186 9110464 49.47 µM 0.711544946300034 0.251158211299102 no 874 0.238373304419437 255 17018021
SGTC_1473 k844-0725 134 µM 0.71115774957797 0.251272113127694 no 875 0.238493243503757 276 54682906
SGTC_300 r073-0011 5.04 µM 0.709437248854923 0.251778563711732 no 876 0.239026589724136 263 2735780
SGTC_1897 st060201 15 µM 0.709032691612055 0.25189772833774 no 877 0.239152094973276 274 611878
SGTC_2998 9066762 71.4286 µM 0.70811042441814 0.252169498607132 no 878 0.23943834326941 263 4945196
SGTC_1728 st035614 33.7865 µM 0.707718736771202 0.252284966435121 no 879 0.239559969741023 260 15945546
SGTC_519 k048-0011 62.8 µM 0.705864834395172 0.252831866854967 no 880 0.240136099072854 260 6836379
SGTC_7 0192-1582 4.227 µM 0.705650440710386 0.252895153138583 no 881 0.240202773969358 295 252616
SGTC_344 k064-0035 6.43 µM 0.705180643078656 0.253033860560327 no 882 0.240348912929376 255 5088750
SGTC_1678 st019265 80.2 µM 0.704259474778749 0.253305950998459 no 883 0.240635599354738 264 5367020
SGTC_3014 9081533 49.47 µM 0.702802617577698 0.253736584548024 no 884 0.241089382871126 292 21367265
SGTC_387 norethindrone acetate 66.7 µM 0.701548011460981 0.254107742377571 no 885 0.241480541547062 268 541197
SGTC_3055 9094636 49.47 µM 0.695318713502669 0.255954802617485 no 886 0.24342779461615 277 25236176
SGTC_2812 7970281 58.44 µM 0.69468353922838 0.256143532060695 no 887 0.243626823027318 280 2233435
SGTC_2254 7938975 95.19 µM 0.6942011679545 0.256286907589505 no 888 0.243778030134202 286 2969277
SGTC_2775 cyproheptadine 69.59 µM 0.691682843761653 0.257036109494392 no 889 0.244568261660782 272 2913 A selective serotonin reuptake inhibitor.
SGTC_1256 0570-0116 285 µM 0.69158435287922 0.257065433680521 no 890 0.244599195383199 275 410638
SGTC_730 1436-0052 41.2 µM 0.691143245361137 0.257196788185963 no 891 0.244737762965034 242 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_6 0844-0013 19.835 µM 0.691126720642651 0.257201709651178 no 892 0.244742954788794 296 1584900
SGTC_3177 9107506 49.47 µM 0.690776816064176 0.257305931283425 no 893 0.244852903585774 267 8897194
SGTC_320 4092-0846 5.34 µM 0.690728303426379 0.257320382859015 no 894 0.244868149571762 274 1359356
SGTC_1297 1068-0111 14.1 µM 0.690294016781994 0.257449772602422 no 895 0.245004654868605 275 767057
SGTC_2883 9059145 45.46 µM 0.688722710570017 0.257918203952698 no 896 0.24549889082893 294 16476510
SGTC_486 niguldipine 82 µM 0.688113608574472 0.258099905794205 no 897 0.245690620690726 262 1236 A calcium channel blocker.
SGTC_1206 3978-0017 132 µM 0.684951050055781 0.259044397816691 no 898 0.246687405156361 267 3873677
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.684047555283339 0.259314552664068 no 899 0.246972568492442 270 803109
SGTC_2394 5221648 200 µM 0.679480646705306 0.260682332770215 no 900 0.248416683053225 281 788586
SGTC_1507 4075-3230 155 µM 0.678521722955921 0.260969999474305 no 901 0.248720477619099 275 659771
SGTC_2274 7947094 46.08 µM 0.677911429082086 0.261153165970899 no 902 0.248913926481001 272 2971028
SGTC_2653 dihydrofissinolide 100 µM 0.677643130798576 0.261233710796267 no 903 0.248998996086051 278 6857746
SGTC_1125 tnp00248 1.32998 µM 0.676200075563828 0.261667143861612 no 904 0.249456812301432 285 24207736
SGTC_441 propafenone 146 µM 0.674514926464579 0.262173758422326 no 905 0.249991999639613 291 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3101 9120531 49.47 µM 0.673232310245105 0.262559694132719 no 906 0.250399754350592 301 24824904
SGTC_3290 9121031 71.43 µM 0.673086999264216 0.262603436139021 no 907 0.250445972180277 275 17014854
SGTC_3241 9133421 49.47 µM 0.672992582258641 0.262631859866188 no 908 0.250476005018406 307 17018221
SGTC_1970 st070122 35.8 µM 0.672836046936834 0.262678987443668 no 909 0.250525801100683 295 102928
SGTC_627 1391-0720 175 µM 0.671788142773909 0.262994587916072 no 910 0.250859289165943 306 997839
SGTC_754 3474-0146 171 µM 0.671608605536429 0.263048679131528 no 911 0.250916449188671 268 24762078
SGTC_766 1391-0721 126 µM 0.670035603279775 0.263522838331468 no 912 0.251417547143145 295 1020919 YIL115C NUP159
SGTC_1189 1431-2119 7.28 µM 0.668940872654077 0.263853086562084 no 913 0.251766598057132 291 3107275
SGTC_316 k060-0003 58.6 µM 0.668344745696208 0.264033009334318 no 914 0.251956778537205 287 6152314
SGTC_645 0845-0943 5.41 µM 0.667765825233875 0.264207798667962 no 915 0.25214154222111 266 1885106
SGTC_1153 4055-0057 267 µM 0.667202783347085 0.26437785040692 no 916 0.252321306752557 290 882706
SGTC_2711 st079103 59.1 µM 0.666154193434209 0.264694697369734 no 917 0.252656274060349 281 54693780
SGTC_2602 kawain 100 µM 0.664504581567169 0.265193542578232 no 918 0.253183708785442 277 5369129
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.662884469509924 0.265683931233366 no 919 0.253702274516375 285 676296 Flavone; oxidizing agent.
SGTC_1185 1319-0113 81.3 µM 0.662428158697085 0.265822134032815 no 920 0.253848431160431 289 4672763
SGTC_248 streptozotocin 5.23457 mM 0.661572149814321 0.266081491588214 no 921 0.254122730530291 303 5300 DNA alkylating agent.
SGTC_3217 9129673 49.47 µM 0.660337288214634 0.266455861351439 no 922 0.254518703138817 287 17248312
SGTC_2419 paclitaxel 166.5 µM 0.659575050901973 0.26668707976907 no 923 0.254763284573928 293 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_290 2043-6722 48.1 µM 0.658063049734634 0.267146032828404 no 924 0.255248808938586 279 773758 YLR208W SEC13
SGTC_2560 caryophyllene 100 µM 0.657659442753072 0.267268611137111 no 925 0.255378494445228 281 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_475 α-linolenic acid 10 µM 0.655200191443147 0.268016116046882 no 926 0.256169435549778 277 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_640 3381-0960 37.1 µM 0.655164597131953 0.268026942884311 no 927 0.256180892714899 289 1745025
SGTC_273 hydroxyurea 18.1 mM 0.652839162730759 0.268734754592228 no 928 0.256929986543997 303 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1225 1216-0074 20.6 µM 0.651744754595671 0.269068193302778 no 929 0.257282922996211 283 4241466
SGTC_2115 tiliquinol 12.7705 µM 0.651137256371369 0.269253372347365 no 930 0.257478944235756 301 71208 A bioactive hydroxyquinoline.
SGTC_2664 lyso-paf C-16 73.48 µM 0.648122937300763 0.270173148640709 no 931 0.258452719802737 302 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1074 carmofur 3.8 µM 0.6462495756286 0.27074556886066 no 932 0.259058868989246 293 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1218 1348-1416 30.7 µM 0.646019631656758 0.270815871728179 no 933 0.259133320807481 285 6787668
SGTC_2299 7976368 114.88 µM 0.644762748664575 0.271200310981745 no 934 0.259540472837368 287 2979718
SGTC_1663 st014140 55.4 µM 0.643783042327456 0.27150015957117 no 935 0.259858065787632 283 4207120
SGTC_2868 9035608 32.47 µM 0.640502661672901 0.272505352327535 no 936 0.260922929638046 285 6462614
SGTC_1699 st031318 29.054 µM 0.639302955443123 0.272873434022182 no 937 0.261312933104126 290 5340658
SGTC_2896 9052656 71.43 µM 0.638947678332392 0.272982483845252 no 938 0.261428484909054 292 6469436
SGTC_1701 st028638 40.4 µM 0.638182991928944 0.273217272262866 no 939 0.26167728368186 283 3490878
SGTC_929 2805-0021 398 µM 0.638135739486231 0.273231783878963 no 940 0.261692661746637 324 3098024
SGTC_2739 tacrine 100.86 µM 0.637440145756612 0.273445450641389 no 941 0.261919092798784 280 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_919 tnp00227 403.569 nM 0.636718900499837 0.273667084146285 no 942 0.262153980030969 320 1269246 A methoxyflavone. YNL221C POP1
SGTC_44 0929-0055 61.211 µM 0.635792710418416 0.273951826007587 no 943 0.262455769667121 281 1379590
SGTC_692 k241-0027 77.8 µM 0.634521776677732 0.274342791812298 no 944 0.262870179824965 283 3600480
SGTC_3231 9132313 49.47 µM 0.634407563466185 0.274377939669816 no 945 0.262907437416961 291 4905967
SGTC_371 0195-0006 7.36 µM 0.633810109212411 0.27456183585169 no 946 0.263102377484992 277 3928593
SGTC_2124 5246320 200 µM 0.62972101184082 0.275822088187782 no 947 0.26443856636262 295 579342
SGTC_1331 1472-0049 76.2 µM 0.629057687500843 0.27602679115866 no 948 0.264655645082053 303 24051409
SGTC_1991 st073000 8.92 µM 0.627792732373472 0.276417365028544 no 949 0.26506986383884 314 4301969 YIL048W NEO1
SGTC_1737 st035557 69.7 µM 0.626619391179814 0.276779893863024 no 950 0.26545437714282 298 5716916
SGTC_2730 imipramine 71.33 µM 0.625722661732847 0.277057114521363 no 951 0.265748433242955 280 3696 A tricyclic antidepressant.
SGTC_1269 0831-0796 3.05 µM 0.624723939221496 0.277366025839787 no 952 0.266076129235765 295 927758
SGTC_801 0866-0028 10.1 µM 0.617965057211852 0.279461006801665 no 953 0.268299186286882 290 6849771
SGTC_762 1165-0429 115 µM 0.616261934621871 0.279990115773893 no 954 0.268860828783989 298 5967793
SGTC_997 3996-0078 137 µM 0.615359909877011 0.28027054433214 no 955 0.269158530446577 289 735687
SGTC_166 k072-0058 166.424 µM 0.614629477038038 0.280497726688495 no 956 0.269399721532027 303 5846229
SGTC_2101 5377231 179.231 µM 0.612085543683245 0.281289646807098 no 957 0.270240580800738 323 2844213
SGTC_29 0299-0004 12.984 µM 0.611738369010598 0.281397805063448 no 958 0.270355435905479 283 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1491 4138-0063 26.5 µM 0.605706918590937 0.283280029708516 no 959 0.272354694481629 301 23883227
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.602795942912073 0.28419060831128 no 960 0.273322223033703 316 279621
SGTC_2864 9034755 47.6 µM 0.602319549537925 0.284339761474243 no 961 0.273480725074863 287 4930451
SGTC_1829 berberine 14.4 µM 0.600865853920582 0.284795127587788 no 962 0.273964668890132 304 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2899 9053889 58.44 µM 0.599760802488866 0.285141514526476 no 963 0.274332829964926 306 6470052
SGTC_2061 5245884 80.95 µM 0.599736081912723 0.285149265678489 no 964 0.274341068712253 324 573863
SGTC_2524 avocatin b 10.57 µM 0.59961966694108 0.285185769015167 no 965 0.274379868541248 288 6710748
SGTC_448 monastrol 171 µM 0.598518105693085 0.285531287189354 no 966 0.27474714080569 309 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1716 st033144 30.6155 µM 0.597804009676095 0.285755378554197 no 967 0.274985357456842 327 674617
SGTC_1254 0550-0035 264 µM 0.595545397960533 0.286464706511223 no 968 0.275739481295816 304 15121435
SGTC_1870 st057514 26.5 µM 0.595019581524618 0.286629961530005 no 969 0.275915190961962 297 5393161
SGTC_1396 3511-0007 98.6 µM 0.594918172894163 0.286661837709821 no 970 0.275949084544289 302 X1396
SGTC_3025 9087895 49.47 µM 0.5946208439836 0.286755307982354 no 971 0.276048471914898 304 17173641
SGTC_900 1112-0045 141 µM 0.594461122386209 0.286805525079066 no 972 0.276101868898585 292 56211 YIL048W NEO1
SGTC_1694 st024011 44.9 µM 0.593208084656961 0.287199629600408 no 973 0.276520951366707 333 2787533
SGTC_547 1120-0019 610 nM 0.587976462353419 0.288847838840152 no 974 0.27827404589683 288 3676939
SGTC_21 0849-0113 22.993 µM 0.587739517594316 0.288922592950332 no 975 0.278353573167258 288 1560156
SGTC_800 3448-7362 155 µM 0.587633994443044 0.288955887560819 no 976 0.278388994135821 307 15991913
SGTC_719 2810-4230 27.3 µM 0.58458226625747 0.289919547372414 no 977 0.279414317346314 315 721079
SGTC_1112 tnp00069 1.16933 µM 0.584129961783302 0.290062502011371 no 978 0.279566439067195 303 145826
SGTC_3143 9086658 49.47 µM 0.58283554557764 0.290471795625424 no 979 0.28000200684872 321 25236626
SGTC_2234 tolnaftate 200 µM 0.581959448086471 0.290748970425677 no 980 0.280296998011595 316 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1013 4112-3890 241 µM 0.581846514386642 0.29078470875194 no 981 0.280335034915582 301 705171
SGTC_2167 5876490 200 µM 0.580254955933853 0.29128858216113 no 982 0.280871349227818 314 686534
SGTC_1802 st050112 57.9 µM 0.580109521093726 0.291334645865935 no 983 0.280920381755268 312 4662563
SGTC_1725 st036284 20.55 µM 0.579175022663886 0.291630711441472 no 984 0.281235541238804 310 707914
SGTC_2942 9052777 62.25 µM 0.578986440212586 0.29169047469066 no 985 0.281299161343866 333 6469503
SGTC_2976 9009005 19.48 µM 0.578247252007643 0.29192478421697 no 986 0.281548600566294 287 2993148
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.577542849299933 0.292148148888747 no 987 0.281786400648239 320 688761
SGTC_499 genistein 192 µM 0.576978381442716 0.292327197883531 no 988 0.281977029812154 332 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_736 0958-0254 92.6 µM 0.575695288248992 0.292734384295026 no 989 0.282410580339737 333 6812352
SGTC_1949 st076024 69.1 µM 0.574939920715161 0.292974221397649 no 990 0.282665964956144 304 2921930
SGTC_876 0720-0963 56.8 µM 0.573009062252258 0.293587703211465 no 991 0.283319279031503 340 765861
SGTC_77 0828-0286 12.516 µM 0.572542668630981 0.293735977216059 no 992 0.283477193780346 301 745345
SGTC_2029 5175081 200 µM 0.572265061680918 0.293824249361973 no 993 0.283571207867725 300 1380876
SGTC_614 0462-0418 107 µM 0.571106300097204 0.294192839345696 no 994 0.283963794127746 305 5188303
SGTC_674 0498-0004 451 µM 0.568988615052247 0.294867004258543 no 995 0.284681933096295 312 4231473
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.566742759211393 0.295582749354466 no 996 0.285444482694731 291 6708739 YPR165W RHO1
SGTC_288 1315-0019 35.1 µM 0.566424643641814 0.295684196036973 no 997 0.285552573067453 325 6811474
SGTC_1845 st056753 3.01 µM 0.565474546031273 0.29598727627103 no 998 0.285875516345014 305 5375839
SGTC_985 1493-0307 8.71 µM 0.565222472246121 0.296067711501184 no 999 0.285961226716531 330 3278274
SGTC_2364 9055074 200 µM 0.562488542762362 0.29694073565153 no 1000 0.286891603792799 318 6470630
SGTC_345 1362-0200 395 µM 0.560054502914208 0.29771898583907 no 1001 0.287721131143343 309 1419823
SGTC_71 0417-1750 47.813 µM 0.559681326121831 0.297838386124915 no 1002 0.287848410929447 282 6811472
SGTC_582 0987-0078 156 µM 0.559136035919189 0.298012894446513 no 1003 0.288034441414224 326 1625765
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.556850952587269 0.298744692159537 no 1004 0.288814633941393 317 616764
SGTC_3302 9125395 16.351 µM 0.556239379342078 0.298940686902446 no 1005 0.289023611092817 305 17599668
SGTC_882 0843-0131 351 µM 0.556046255014397 0.299002590807885 no 1006 0.289089617262358 312 5425421
SGTC_756 0508-1999 28.3 µM 0.555188868904429 0.299277486874448 no 1007 0.289382740862015 336 6753853
SGTC_439 amiodarone 34.4 µM 0.555073070909994 0.29931462294004 no 1008 0.289422340640138 340 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3212 9128307 49.47 µM 0.552195356275111 0.300238167878719 no 1009 0.290407257798885 314 27243542
SGTC_1245 0418-0076 17.2 µM 0.551595979215067 0.300430687940668 no 1010 0.290612595906295 345 6790114
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.549716795455839 0.301034643426971 no 1011 0.291256817609655 321 15053
SGTC_1376 2910-0861 41.3 µM 0.549553482981125 0.301087156662495 no 1012 0.29131283585578 332 1112859
SGTC_3029 9088683 49.47 µM 0.549033872979647 0.301254265062871 no 1013 0.291491102105852 290 25236615
SGTC_3100 9120536 49.47 µM 0.548664817887585 0.301372979840757 no 1014 0.291617747320886 320 16421196
SGTC_1743 st037606 46.3785 µM 0.547545863702189 0.301733044999653 no 1015 0.292001885167226 292 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_221 trifluoperazine 10.304 µM 0.546558485357866 0.302050931270375 no 1016 0.292341048463413 327 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1232 0279-0259 161 µM 0.545026081103786 0.302544586116366 no 1017 0.292867789996558 333 1560000
SGTC_1467 k284-1082 293 µM 0.544861834133697 0.302597518745013 no 1018 0.292924273618432 328 3334705
SGTC_223 busulfan 5 mM 0.544058133798618 0.302856590778648 no 1019 0.293200734571638 318 2478 A DNA alkylator.
SGTC_231 b-estradiol 524 µM 0.544023453710266 0.302867772106677 no 1020 0.293212666728032 296 450 A steroid.
SGTC_1203 3992-3522 103 µM 0.543412739990684 0.303064704718991 no 1021 0.293422827974571 360 5322312
SGTC_1606 st000094 49.2 µM 0.541576909342237 0.303657036903821 no 1022 0.294055001155975 316 1242210
SGTC_2781 5567276 71.43 µM 0.541569839936611 0.303659318851602 no 1023 0.29405743674107 332 2853274
SGTC_1563 conessine 56.1 µM 0.540692397172167 0.303942609795964 no 1024 0.29435980985394 353 441082 An anti-amoebic, histamine inhibitor.
SGTC_2467 5474540 200 µM 0.540409429516644 0.304033993784557 no 1025 0.294457353157565 305 5413519
SGTC_2874 9043904 71.43 µM 0.53949481241251 0.304329451767067 no 1026 0.294772737745407 318 4463428
SGTC_1130 3454-2858 15.9 µM 0.537185273644096 0.30507609370386 no 1027 0.295569821231886 341 715628 YIL048W NEO1
SGTC_2280 7785178 200 µM 0.53659991503211 0.305265461165631 no 1028 0.295772001415737 314 2954328
SGTC_630 4356-0227 183 µM 0.534855026466467 0.305830253569598 no 1029 0.296375054597572 343 779312
SGTC_1345 1488-0192 31.4 µM 0.534726104307122 0.30587200195087 no 1030 0.296419633905261 335 658348
SGTC_646 4092-0839 27.3 µM 0.5337960283511 0.306173259691017 no 1031 0.296741330951828 352 877796
SGTC_3214 9129694 49.47 µM 0.533730736131161 0.306194413199537 no 1032 0.296763920394944 356 17158655
SGTC_3016 9080866 49.47 µM 0.533479979133497 0.306275659976064 no 1033 0.296850683238419 328 17066299
SGTC_1841 st054148 70 µM 0.531277344696922 0.306989735825104 no 1034 0.29761330119695 341 675442
SGTC_635 k038-0028 24.7 µM 0.528715991455292 0.307821026853893 no 1035 0.298501241082243 350 4035102
SGTC_1046 2001-0062 216 µM 0.525199189249002 0.308964018463359 no 1036 0.299722364239742 320 739778
SGTC_293 4049-0273 38.5 µM 0.522559362163033 0.309823203294939 no 1037 0.300640463218331 318 1380311
SGTC_1733 st037357 54.9 µM 0.522101886143173 0.309972203918488 no 1038 0.300799696656122 344 1272339 YGL099W LSG1
SGTC_1573 oleylamine 1.06 µM 0.51967246260301 0.310763993373941 no 1039 0.301645941596476 334 5356789 An amine of the fatty acid oleic acid.
SGTC_593 1203-0218 61.7 µM 0.517747755220356 0.311391910471782 no 1040 0.302317137123904 350 3666956
SGTC_1035 k081-0041 55.2 µM 0.513590568616645 0.31275002430721 no 1041 0.303769137454675 335 731709
SGTC_1687 st020778 55.3625 µM 0.51333518388339 0.312833539289292 no 1042 0.303858438265545 314 4259299
SGTC_870 0573-2213 57.6 µM 0.512985103949536 0.312948036760926 no 1043 0.303980870330852 320 3916321
SGTC_487 nimodipine 119 µM 0.512574985816412 0.313082193333384 no 1044 0.304124327285441 336 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2100 5377183 190 µM 0.512212535889085 0.31320077743246 no 1045 0.304251135283086 332 2844202
SGTC_1017 4239-0030 168 µM 0.511274641977478 0.313507721350542 no 1046 0.30457937938059 310 1149593
SGTC_3262 9137218 49.47 µM 0.510706807820458 0.313693618856844 no 1047 0.304778186497994 299 17650664
SGTC_1415 3966-0071 78.1 µM 0.510657314837776 0.313709824108429 no 1048 0.304795517454197 336 2893185
SGTC_1451 4152-0210 104 µM 0.510427792164084 0.31378498032245 no 1049 0.304875895127016 355 659563
SGTC_2408 sulbentine 18.36 µM 0.509370158609944 0.314131397695734 no 1050 0.305246394645476 307 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2855 9016525 58.44 µM 0.508852262300962 0.314301089261436 no 1051 0.305427891694132 343 43811474
SGTC_1146 3579-1023 7 µM 0.508610827414528 0.314380210143136 no 1052 0.305512519034616 349 X1146
SGTC_3280 9140961 49.47 µM 0.507089324775307 0.314879019470661 no 1053 0.30604607248254 348 4901226
SGTC_723 4182-0001 115 µM 0.504616793402837 0.315690334439274 no 1054 0.306914006218369 342 744821 YLR208W SEC13
SGTC_1513 0337-0559 19 µM 0.503208392789936 0.316152872481536 no 1055 0.30740888234244 328 775073
SGTC_3022 9087993 49.47 µM 0.501382570968213 0.316752925806876 no 1056 0.308050951785955 357 17173644
SGTC_335 4077-0256 27.6 µM 0.497877794217532 0.317906115860918 no 1057 0.309285089781422 346 3121989
SGTC_1377 2944-0135 198 µM 0.495327294669085 0.318746428820942 no 1058 0.310184553519663 324 1894137
SGTC_1547 harmine 94.2 µM 0.493631474716885 0.319305667168489 no 1059 0.310783234036996 343 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2091 4-phenylthiadiazole 200 µM 0.49294101609266 0.319533480797169 no 1060 0.311027132460474 336 270010
SGTC_1514 1189-1591 158 µM 0.488950061143072 0.320851610621333 no 1061 0.312438526279363 366 767698 YMR146C TIF34
SGTC_1468 k284-1086 134 µM 0.488888880690012 0.320871834899497 no 1062 0.312460184131764 340 15996457
SGTC_2118 5526350 200 µM 0.485779449978769 0.321900411007732 no 1063 0.313561772956331 346 743594
SGTC_3015 9080845 49.47 µM 0.485020241748202 0.322151759131516 no 1064 0.313830993533104 348 5296973
SGTC_358 0075-0058 9.45 µM 0.48400024891344 0.322489572267439 no 1065 0.31419284623429 381 1069125
SGTC_1443 4112-3303 14 µM 0.482765234163997 0.322898795090087 no 1066 0.314631219245862 344 704433
SGTC_1462 k081-0014 26.5 µM 0.482569933980955 0.322963527570052 no 1067 0.31470056571573 322 3270634
SGTC_2477 5967686 25.23 µM 0.482203860170299 0.323084877620446 no 1068 0.314830567462207 357 776118
SGTC_969 1313-0238 134 µM 0.482158922162251 0.323099775448555 no 1069 0.314846527627694 351 5212874
SGTC_1646 st011709 75.6 µM 0.481636007399543 0.323273152771643 no 1070 0.315032271249954 340 5757843
SGTC_1672 st016598 6.51 µM 0.481572238595907 0.323294298547125 no 1071 0.315054925654644 369 4665860 YNL267W PIK1
SGTC_2384 9036245 200 µM 0.481516223880559 0.323312873533019 no 1072 0.31507482592811 321 6462766
SGTC_1091 telmisartan 47.6 µM 0.480276630998151 0.323724046388936 no 1073 0.315515351728638 355 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_315 k915-0449 187 µM 0.478879470167904 0.324187742556465 no 1074 0.316012188392997 346 20970215 YNL149C PGA2
SGTC_1591 genipin 88.4 µM 0.475997235133234 0.325145173371268 no 1075 0.317038173833544 349 442424 A DNA cross-linking agent.
SGTC_13 0199-0087 65 µM 0.475809140347115 0.325207695583861 no 1076 0.317105178720801 348 4589825
SGTC_573 3702-0553 84.7 µM 0.474098499167731 0.325776533925025 no 1077 0.317714834404494 332 1222756
SGTC_831 k061-1017 217 µM 0.473583367444465 0.325947909895893 no 1078 0.317898519248446 366 1240153
SGTC_270 tamoxifen 5.46 µM 0.473552189316334 0.325958283534165 no 1079 0.317909638134112 367 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2023 5144124 124 µM 0.47337619551022 0.326016843010224 no 1080 0.31797240492317 351 2830192
SGTC_2465 5809242 33.21 µM 0.470439745194754 0.32699453793206 no 1081 0.319020436899792 365 2731748
SGTC_2025 5147754 141 µM 0.470231316744709 0.327063979710383 no 1082 0.319094881075611 341 315777 YLR208W SEC13
SGTC_2520 obtusaquinone 4.71 µM 0.468462479090408 0.327653541392714 no 1083 0.319726948471307 380 5967872
SGTC_2411 st077133 39.94 µM 0.466529333044933 0.328298359532227 no 1084 0.320418328169803 371 1403142 YNL221C POP1
SGTC_1921 5740136 50 µM 0.466275282958675 0.328383138304428 no 1085 0.320509234291635 371 1774243
SGTC_1850 st056238 17 µM 0.464863547032155 0.328854408038738 no 1086 0.321014588376309 359 5393177
SGTC_3320 9137005 35.139 µM 0.464824673610615 0.328867388730457 no 1087 0.321028508453629 358 4908713
SGTC_1288 0973-0013 65.5 µM 0.463900036442332 0.329176206266905 no 1088 0.321359683358899 342 4315430
SGTC_909 3448-9333 149 µM 0.461859099324134 0.329858266866318 no 1089 0.32209118315101 353 3344074
SGTC_2523 spermine 47.74 µM 0.460288458901641 0.330383544662493 no 1090 0.322654592020747 338 1103 A DNA binding polyamine.
SGTC_2638 epoxomicin 18 µM 0.457436640363999 0.331338148030927 no 1091 0.323678616727203 381 9915668 A protesome inhibitor.
SGTC_1968 st069590 43.6 µM 0.456163287502311 0.331764738378423 no 1092 0.324136281536629 357 6384066
SGTC_379 3970-0972 5.9 µM 0.452899310230782 0.332859210308604 no 1093 0.325310623826388 337 2898042 YBL034C STU1
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.452789026970409 0.332896215274814 no 1094 0.325350332899208 398 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1917 st066507 28.5 µM 0.451176161761828 0.333437589487281 no 1095 0.325931294554392 350 3156428
SGTC_1328 1441-0025 69.2 µM 0.449503409936537 0.333999431941855 no 1096 0.326534274393195 353 4562601
SGTC_254 nsc-64875 3.808 µM 0.448965148597915 0.33418030192948 no 1097 0.326728398938671 351 56993
SGTC_163 TUB2.036 7.546 µM 0.448733272557189 0.334258230258195 no 1098 0.326812039750416 349 15992207 YJR013W GPI14
SGTC_1424 4048-1941 275 µM 0.44826749193047 0.334414790250807 no 1099 0.326980079394509 382 X1424
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.446916944247998 0.334868904339917 no 1100 0.327467514658135 369 5282309
SGTC_3064 1327-0027 10 µM 0.444564191446632 0.335660580966471 no 1101 0.328317365013505 365 16000455 YPR107C YTH1
SGTC_885 0865-0106 16.8 µM 0.444267075434808 0.335760609373212 no 1102 0.328424751195116 351 2793380
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.443819275137826 0.335911389811472 no 1103 0.328586625745791 339 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_751 0833-0568 350 µM 0.443252585409124 0.33610223979662 no 1104 0.328791523548934 375 6954252
SGTC_392 N-ethylmaleimide 8.33 µM 0.442089440126307 0.3364940966492 no 1105 0.329212242768445 335 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_665 3914-0008 307 µM 0.440141180506875 0.337150851756491 no 1106 0.329917428862445 360 1069549
SGTC_2772 vinpocetine 57.06 µM 0.439140455586265 0.33748838767369 no 1107 0.33027988350615 400 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_543 3844-1095 191 µM 0.438840911174421 0.337589446878001 no 1108 0.33038840711549 358 4230703
SGTC_2250 alverine citrate 130 µM 0.438067928416421 0.337850287089101 no 1109 0.330668521224016 335 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_877 0771-0151 33.1 µM 0.437983438191473 0.337878802731492 no 1110 0.33069914461302 365 6166523
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.437899895536556 0.33790699948173 no 1111 0.330729425670566 345 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2120 5538279 151.968 µM 0.436948428248497 0.338228196403561 no 1112 0.331074374744515 345 2058197
SGTC_1171 0368-0077 21.4 µM 0.43604601958047 0.33853294091304 no 1113 0.331401670434265 375 3239779
SGTC_1597 7-benzyloxygramine 47.5 µM 0.435322216780852 0.338777446450976 no 1114 0.331664280450255 359 260807
SGTC_1976 st070609 63.5 µM 0.434104573934792 0.339188927806698 no 1115 0.332106252093327 365 682556
SGTC_1862 st057513 3.81 µM 0.433947041211483 0.339242177295627 no 1116 0.332163449323225 358 5393163
SGTC_95 0471-0001 561.058 µM 0.433096543325122 0.339529719529206 no 1117 0.332472316951235 331 4015405
SGTC_1998 st075797 76.8 µM 0.433079849685907 0.339535364366241 no 1118 0.33247838056853 350 24208315
SGTC_156 3474-0145 5.642 µM 0.432382347339144 0.339771252054737 no 1119 0.332731772956216 356 2265471
SGTC_2008 4012253 172 µM 0.432290256963029 0.339802400707976 no 1120 0.33276523375511 354 603940
SGTC_2928 9011484 9.79 µM 0.43181039177544 0.339964728028849 no 1121 0.332939613074482 379 2994751
SGTC_2977 9011197 71.43 µM 0.429738941765288 0.340665791976761 no 1122 0.333692776354365 407 2704722
SGTC_2738 aclarubicin 5.55 µM 0.428717295031552 0.34101176225426 no 1123 0.334064486395792 340 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2453 5731132 22.18 µM 0.42530767763456 0.342167361025439 no 1124 0.335306198707615 376 1362040
SGTC_3207 9114163 49.47 µM 0.42493568538257 0.342293527582884 no 1125 0.335441779845691 405 849233
SGTC_1439 4092-1168 46 µM 0.423356234503775 0.342829417122632 no 1126 0.336017685587395 379 2886240
SGTC_2551 apiole 73.87 µM 0.423064805808191 0.34292833013748 no 1127 0.3361239896237 361 10659 A possible DNA adduct former.
SGTC_2748 diazoxide 86.69 µM 0.418926185276967 0.344334167236587 no 1128 0.337635039668819 363 3019 A potassium channel activatior.
SGTC_464 bw-b 70c 158 µM 0.418175891533134 0.344589263701395 no 1129 0.337909260504078 389 5353454
SGTC_2267 7931562 200 µM 0.41545649969342 0.345514436273348 no 1130 0.338903876657912 351 934880
SGTC_2015 5119600 184 µM 0.412452839470177 0.346537394126095 no 1131 0.340003770359768 397 2828786
SGTC_2473 5854593 8.94 µM 0.410097598608376 0.347340303532734 no 1132 0.340867177108762 374 2872951
SGTC_215 1287-0124 461.5 µM 0.40967328038371 0.347485028003507 no 1133 0.341022816560798 384 5560863
SGTC_1360 1598-0022 39.8 µM 0.407869565407211 0.348100478579012 no 1134 0.341684718891701 401 761525
SGTC_858 0438-0351 2.77 µM 0.406709564931921 0.348496497165643 no 1135 0.342110657284903 357 2799119
SGTC_1965 Pectolinarigenin 58.4 µM 0.406578911228137 0.348541112070397 no 1136 0.342158644375962 367 5320438 An anti-inflammatory.
SGTC_668 1682-0499 62.6 µM 0.406552844177945 0.348550013553367 no 1137 0.342168218706667 370 682214
SGTC_2429 5902844 64.44 µM 0.405320147237563 0.348971055090068 no 1138 0.342621099470867 388 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3222 9128301 49.47 µM 0.404878033906638 0.349122109231627 no 1139 0.34278358274652 358 4911358
SGTC_2626 ethyl orsellinate 100 µM 0.403185778867664 0.349700512307781 no 1140 0.343405780352834 370 75653 A natural product.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.402927119459402 0.34978895139714 no 1141 0.343500920057247 381 688669
SGTC_2894 9048625 32.47 µM 0.402627273657773 0.349891482862816 no 1142 0.343611221287133 411 4092861
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.400692835568216 0.350553221597367 no 1143 0.344323143110394 359 688664
SGTC_2074 5212007 75.395 µM 0.399404096480061 0.350994329557006 no 1144 0.344797738006278 393 758611
SGTC_359 0081-0058 15.9 µM 0.397851074893234 0.351526162651039 no 1145 0.34536998295364 437 3494159
SGTC_128 0906-2981 13.371 µM 0.396291318625337 0.352060594730198 no 1146 0.345945065427476 374 6740226
SGTC_1746 st038117 42 µM 0.396254094731397 0.352073352634038 no 1147 0.345958794234161 371 2898218
SGTC_1864 st057645 30.4 µM 0.394475706622342 0.352683060942738 no 1148 0.346614929738814 382 688666
SGTC_2905 7799065 20.05 µM 0.393886679538406 0.352885088431414 no 1149 0.346832352618958 392 1296806
SGTC_2082 5219693 150 µM 0.392480532076928 0.353367543641745 no 1150 0.34735159649572 368 2834649
SGTC_960 1222-0186 7.7 µM 0.392296125566998 0.353430831804019 no 1151 0.347419713016464 387 3126296
SGTC_2085 5307070 144.047 µM 0.392187238552959 0.353468203640648 no 1152 0.347459936278022 402 2840351
SGTC_2213 7173844 200 µM 0.391980866963532 0.353539037682788 no 1153 0.347536175411158 375 892728
SGTC_3045 9092950 49.47 µM 0.39084476888975 0.353929077562456 no 1154 0.347955990501123 368 44120432
SGTC_1574 spiramycin 23.7 µM 0.390724685881801 0.353970312867033 no 1155 0.348000374914213 373 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_186 3455-3465 67.277 µM 0.389630948582355 0.35434597011637 no 1156 0.348404731806877 390 755278
SGTC_2906 7926292 26.41 µM 0.389490547739042 0.354394202751154 no 1157 0.348456650773862 393 2966319
SGTC_2742 clothiapine 36.27 µM 0.388401106890013 0.35476854336758 no 1158 0.348859612609814 391 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_607 4491-0986 66.8 µM 0.388154219730896 0.354853395285868 no 1159 0.348950954826802 368 698981 YDR232W HEM1
SGTC_1148 3909-7663 27.7 µM 0.386752040688039 0.355335442526642 no 1160 0.349469892713855 382 4084526
SGTC_3046 9092212 49.47 µM 0.386465595664617 0.355433946356788 no 1161 0.349575938919575 398 25236637
SGTC_18 0111-0177 500 nM 0.386225966647955 0.355516358335761 no 1162 0.349664662162698 380 721752
SGTC_2541 muurolladie-3-one 83.07 µM 0.385996966604662 0.355595121165663 no 1163 0.349749457675406 404 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1792 st045773 43.6 µM 0.385182274461812 0.355875378327274 no 1164 0.35005118752177 362 2919270
SGTC_3176 9106582 49.47 µM 0.383284604743776 0.356528485708729 no 1165 0.35075437646243 363 17018027
SGTC_1312 1218-2183 165 µM 0.382910330925456 0.356657346602841 no 1166 0.350893125565877 373 6744073
SGTC_1233 0325-0408 14.2 µM 0.381775376894176 0.357048206464526 no 1167 0.351313992124279 400 12874
SGTC_1997 st073024 93.8 µM 0.380904476232834 0.357348232397637 no 1168 0.351637065442567 395 686268
SGTC_3120 9124077 49.47 µM 0.376525777776544 0.358858030514386 no 1169 0.353263027592643 409 18774327 YGL155W CDC43
SGTC_1309 pyrazolanthrone 13.4 µM 0.375527034997646 0.359202712316054 no 1170 0.353634272053174 415 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1721 st082152 9.2685 µM 0.375518812714021 0.35920555043124 no 1171 0.353637328951299 376 5296051
SGTC_234 nsc-17383 10.7 µM 0.374440334634845 0.35957787987539 no 1172 0.354038369573789 376 408974
SGTC_1942 st076330 65.2 µM 0.371533451649605 0.360582103673396 no 1173 0.355120122624713 397 24208414
SGTC_3276 9139060 49.47 µM 0.371427847816308 0.360618604165335 no 1174 0.355159443564681 416 4870619
SGTC_3 0833-0587 95.581 µM 0.369611464555078 0.36124661021593 no 1175 0.355836003827689 369 5382644
SGTC_122 0236-0016 402.397 µM 0.368394810605173 0.361667471987605 no 1176 0.356289433174224 393 6808838
SGTC_89 0302-0250 142.109 µM 0.368251561391828 0.361717035407504 no 1177 0.356342833473239 384 4203518 YLR208W SEC13
SGTC_1854 st056233 32.9 µM 0.367298285075964 0.362046922687454 no 1178 0.356698266571787 396 5393174
SGTC_3287 9117173 37.0625 µM 0.367165350830197 0.362092933570978 no 1179 0.356747841561919 376 2789709
SGTC_1054 3429-0080 167 µM 0.366910357489932 0.362181196833883 no 1180 0.35684294265842 404 1162877
SGTC_2123 5259487 200 µM 0.366046682429794 0.362480203294572 no 1181 0.357165120854792 398 2173474
SGTC_1712 st032288 53.4 µM 0.365110803259101 0.362804301714861 no 1182 0.357514348470483 382 2883011
SGTC_2828 7998861 71.43 µM 0.361982271249703 0.363888436342797 no 1183 0.358682639425201 378 2988188
SGTC_1888 azatryptophan 97.5 µM 0.359418500838575 0.364777676791093 no 1184 0.359641018233043 366 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1627 st003713 25.6 µM 0.355632868274332 0.366092048463398 no 1185 0.361057762735031 376 16195070 YER133W GLC7
SGTC_3183 9108214 49.47 µM 0.353856925685259 0.366709198749231 no 1186 0.361723054692441 392 4974831
SGTC_854 0422-0053 192 µM 0.352508991890272 0.367177843734393 no 1187 0.362228288080001 389 3596728
SGTC_1838 st055369 84.5 µM 0.352489361173477 0.367184670338602 no 1188 0.36223564785348 348 676036
SGTC_2757 clomiphene 4.22 µM 0.352373706058977 0.367224890389202 no 1189 0.362279009272585 432 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_577 r071-0003 38.6 µM 0.35012198323187 0.368008235988563 no 1190 0.363123576771355 400 4568517 YMR134W ERG29
SGTC_2132 5317594 122.667 µM 0.347819900675289 0.368809668902135 no 1191 0.363987721586885 418 794577
SGTC_196 k015-0023 18.111 µM 0.347814343485761 0.368811604240068 no 1192 0.363989808457419 379 5211998
SGTC_2827 7993847 71.43 µM 0.347047392367646 0.369078733301404 no 1193 0.364277857401181 399 2985692
SGTC_2305 7443522 69.23 µM 0.346739361525037 0.369186038246978 no 1194 0.364393568189313 403 5415886
SGTC_133 0724-0033 378.92 µM 0.346238162291745 0.369360656692142 no 1195 0.364581868468776 415 280309
SGTC_2816 7982706 58.44 µM 0.34560598111768 0.369580947849761 no 1196 0.364819425192853 376 2981853
SGTC_3279 9140807 49.47 µM 0.345524684379597 0.369609279787704 no 1197 0.364849978094481 407 45595718
SGTC_1168 k815-0004 80.5 µM 0.345470002039634 0.36962833699807 no 1198 0.364870529268399 402 642433
SGTC_914 3820-6779 408 µM 0.344199643742204 0.370071156556876 no 1199 0.365348075102822 360 2893481
SGTC_993 3909-8757 62.7 µM 0.343594902708247 0.370282016833378 no 1200 0.365575479316156 369 4288324 YLR208W SEC13
SGTC_2438 5259590 200 µM 0.34333924733064 0.37037117012927 no 1201 0.365671629078944 418 1201127
SGTC_2731 amoxapine 43.43 µM 0.343257885185686 0.370399544564197 no 1202 0.365702230444344 417 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1863 st057641 20.1 µM 0.342927468117427 0.370514782271811 no 1203 0.365826513400449 411 3921635
SGTC_2217 6934799 96.0675 µM 0.342456840683909 0.370678940421935 no 1204 0.366003559344831 392 675606
SGTC_2202 7226349 200 µM 0.342454723588852 0.370679678932762 no 1205 0.366004355842065 370 844334
SGTC_2715 st079500 56.4 µM 0.341520227190865 0.371005707810267 no 1206 0.366355990063059 403 28246688
SGTC_2320 7373003 200 µM 0.340834621705156 0.371244962068816 no 1207 0.36661404249803 376 5415828
SGTC_2717 st081029 62.2815 µM 0.340439277069131 0.371382947257296 no 1208 0.366762872179709 434 5292846
SGTC_2482 5981709 142.65 µM 0.340416948506776 0.371390740978665 no 1209 0.366771278488738 404 877755
SGTC_1070 indatraline 8.81 µM 0.340351241937529 0.371413675976216 no 1210 0.366796016221237 420 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3356 9151811 4.48 µM 0.338284090525301 0.372135451668238 no 1211 0.367574555838421 405 1859254 YPR165W RHO1
SGTC_446 go6976 132 µM 0.33786812468354 0.372280746539292 no 1212 0.367731284631482 428 3501 A protein kinase C inhibitor.
SGTC_2024 5144227 134 µM 0.336182246102563 0.372869801821425 no 1213 0.368366720070083 395 3475211
SGTC_3192 9110362 49.47 µM 0.335221586262909 0.373205594773526 no 1214 0.368728969832643 413 16649480
SGTC_504 lovastatin 124 µM 0.335191625306832 0.373216068998392 no 1215 0.368740269517115 416 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1363 1636-0063 10.4 µM 0.334284638652244 0.373533192053321 no 1216 0.369082390478938 407 6072185
SGTC_1534 6-azauridine 81.6 µM 0.333150346361394 0.373929911846016 no 1217 0.369510398501582 398 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_864 0469-0573 172 µM 0.332582145173747 0.374128690989355 no 1218 0.369724861462194 408 689425
SGTC_3348 9149464 3.537 µM 0.329979960173149 0.375039464661393 no 1219 0.370707552144522 375 1951442
SGTC_1476 4112-3294 3.34 µM 0.329306846015257 0.37527517063328 no 1220 0.370961885035674 417 704369
SGTC_123 0083-0120 66.675 µM 0.328962428505893 0.375395794143363 no 1221 0.371092043318382 388 16001701
SGTC_2174 5790901 200 µM 0.328305159495742 0.375626019769609 no 1222 0.371340471737555 399 786020
SGTC_2304 7443016 91.4 µM 0.326462794653226 0.376271591990251 no 1223 0.372037117097623 396 939854
SGTC_520 3584-0023 682 µM 0.325455840624843 0.376624579309843 no 1224 0.372418049497135 363 1340790
SGTC_83 0170-0301 39.027 µM 0.324826895475178 0.376845108142885 no 1225 0.372656043874269 402 3089716
SGTC_2478 5763493 32.33 µM 0.324737082978885 0.376876602635553 no 1226 0.372690033111375 411 1365576 YLR208W SEC13
SGTC_1509 1326-1131 80 µM 0.323760660273069 0.377219057014786 no 1227 0.37305962092179 401 768313
SGTC_3131 9127911 49.47 µM 0.320728644605985 0.378283070639316 no 1228 0.374208018947988 390 45595681
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.320215107314171 0.378463376001228 no 1229 0.374402635844884 435 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3204 9114183 49.47 µM 0.319923786264049 0.37856567196104 no 1230 0.37451305296135 378 17027248
SGTC_415 dibenzyl ketone 100 µM 0.31966230750404 0.378657496193914 no 1231 0.374612167954631 431 7593
SGTC_2592 piperlongumine 83.33 µM 0.319078562043265 0.378862516444128 no 1232 0.374833469836279 405 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2256 7954252 200 µM 0.318545697747783 0.379049696222187 no 1233 0.375035518313677 415 2972920
SGTC_1754 st042065 16.137 µM 0.318360785967321 0.379114657001218 no 1234 0.375105640138281 408 1126236 YIL048W NEO1
SGTC_2811 7967822 32.47 µM 0.317922251427996 0.379268730844296 no 1235 0.375271956708595 381 2232244
SGTC_367 0335-0881 7.1 µM 0.31641138643383 0.379799701834418 no 1236 0.375845137735643 428 23828853
SGTC_3070 9117005 49.47 µM 0.314404234896569 0.380505435830525 no 1237 0.376607020066588 410 8779016
SGTC_3125 9127534 49.47 µM 0.314149108964848 0.380595169138738 no 1238 0.3767038962617 402 1639235
SGTC_2564 betulinic acid 100 µM 0.313072644970437 0.380973855495854 no 1239 0.377112735656645 394 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_467 ro 31-8220 72.8 µM 0.309944107056334 0.382075081479647 no 1240 0.378301730332312 407 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3062 9077494 49.47 µM 0.309271811951022 0.382311850124221 no 1241 0.378557385694086 376 16459633
SGTC_2073 5212005 126 µM 0.307415669612812 0.382965773894445 no 1242 0.379263501324757 439 691789
SGTC_1525 8-methoxypsoralen 92.5 µM 0.307311614709774 0.383002442602268 no 1243 0.379303097951675 448 4114 Related to psoralen; DNA damaging agent.
SGTC_2102 5377816 72.7585 µM 0.30676104711895 0.383196478794694 no 1244 0.379512629754336 431 1379702
SGTC_2605 digitonin 300 nM 0.306567580056166 0.38326466923203 no 1245 0.379586266726926 402 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2437 5741531 144.16 µM 0.305081464919707 0.383788593787205 no 1246 0.380152053774953 437 2262990
SGTC_847 0342-0274 5.54 µM 0.303170510547414 0.384462606094305 no 1247 0.380879960625969 431 18097
SGTC_1744 st037937 38.9 µM 0.303155307321677 0.384467969824581 no 1248 0.380885753422783 379 1016152
SGTC_63 0099-0242 26.702 µM 0.303005797449921 0.384520718402516 no 1249 0.380942721723068 402 3898502 YLR359W ADE13
SGTC_2691 st077356 60.2 µM 0.302860415599496 0.384572012623718 no 1250 0.380998119583058 416 2839272
SGTC_3122 9126309 49.47 µM 0.302227787709163 0.384795242512239 no 1251 0.381239211288891 460 17591206
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.301814870577131 0.384940965587422 no 1252 0.381396597061632 430 551469
SGTC_3244 9134489 49.47 µM 0.301237723067841 0.385144674631534 no 1253 0.381616613064245 417 16584271
SGTC_589 1227-0070 34.1 µM 0.300810312803775 0.385295553095442 no 1254 0.381779571975023 412 2841384
SGTC_1197 1601-0112 267 µM 0.299856329399518 0.385632377730053 no 1255 0.382143373208187 411 7350313
SGTC_2197 6588183 93.1375 µM 0.299340341108235 0.385814594606472 no 1256 0.382340188552248 396 884136
SGTC_1002 4049-0206 172 µM 0.29901446876636 0.385929686637366 no 1257 0.382464502924616 404 4662749
SGTC_1008 4106-0037 6 µM 0.297785771648994 0.386363729760454 no 1258 0.382933337377125 440 2905394
SGTC_474 dl-dihydrosphingosine 5 µM 0.296944369149814 0.38666104129501 no 1259 0.383254490680192 384 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3190 9110366 49.47 µM 0.295706288828776 0.387098640801125 no 1260 0.383727197038642 436 17123768
SGTC_2517 totarol 10 µM 0.29535021134012 0.387224522995253 no 1261 0.3838631816001 384 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2332 7982454 138.89 µM 0.294599862955527 0.387489828512503 no 1262 0.384149783435831 433 2981748
SGTC_2667 digitoxin 100 µM 0.293888953389363 0.387741237874415 no 1263 0.38442137974081 410 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1753 st043925 64 µM 0.293800010161148 0.387772695485975 no 1264 0.38445536366034 419 670181
SGTC_1692 fluoroquinolonic acid 71 µM 0.291810012956819 0.388476713763877 no 1265 0.385215944528375 422 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_958 1222-0007 33 µM 0.288993186030939 0.389473872778047 no 1266 0.386293295977685 426 7312461
SGTC_1569 carminic acid 40.6 µM 0.287826598351366 0.389887059370309 no 1267 0.386739737996651 438 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1835 st008666 49.2 µM 0.287582484664529 0.389973536273988 no 1268 0.38683317697258 410 690455
SGTC_2635 hydroquinidine 100 µM 0.287366099775046 0.390050194846543 no 1269 0.386916007729136 392 442912 An experimental heart treatment.
SGTC_336 4111-0029 111 µM 0.287216828133874 0.390103079732943 no 1270 0.386973150964366 429 3131175
SGTC_2687 chenodiol 100 µM 0.285050543248876 0.390870793113183 no 1271 0.387802709760881 397 5702181 A cholesterol synthesis inhibitor.
SGTC_608 k048-0125 159 µM 0.28373965104533 0.391335569284185 no 1272 0.388304952913969 431 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2537 larixol 68.93 µM 0.282855452370992 0.391649149165352 no 1273 0.388643822207269 427 6708759
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.281233357726858 0.392224605815261 no 1274 0.389265710464543 431 689007
SGTC_1773 st048542 73.5835 µM 0.280732335159349 0.392402397027545 no 1275 0.389457852894971 407 3237138
SGTC_1136 pergolide 1.05886 µM 0.279896664515648 0.392698990306325 no 1276 0.38977839315961 451 47811 A dopamine receptor agonist.
SGTC_1903 st060211 78.3 µM 0.277822853344375 0.393435288936388 no 1277 0.39057417355129 405 688960
SGTC_1028 k015-0029 4.8 µM 0.277459837298332 0.393564215663986 no 1278 0.390713520400169 407 4588309
SGTC_1190 1486-1332 13 µM 0.276705412030104 0.393832190392161 no 1279 0.391003157940314 438 4150046
SGTC_1352 1496-0991 99 µM 0.276043569442699 0.394067320809167 no 1280 0.391257301109049 456 3000039
SGTC_278 4092-0821 23.9 µM 0.274785866976016 0.39451424655736 no 1281 0.3917403784025 423 877900
SGTC_2417 cerulenin 830 nM 0.271105162504906 0.39582298429167 no 1282 0.393155075557685 449 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2988 9073640 71.4286 µM 0.270652953134434 0.395983856472813 no 1283 0.39332898226812 430 9102229
SGTC_1010 4112-3296 15.2 µM 0.270515612874198 0.396032718383704 no 1284 0.393381803595509 412 704384
SGTC_353 1988-1175 58.3 µM 0.26955415798373 0.396374823460649 no 1285 0.393751635895473 425 2788357
SGTC_154 3389-1638 511.116 µM 0.269399592449535 0.396429828453444 no 1286 0.393811099875331 452 5238686
SGTC_325 2810-4341 181 µM 0.268475319213405 0.396758791096485 no 1287 0.394166735078125 416 774970
SGTC_1935 st074532 41.6 µM 0.268223054621426 0.396848588606563 no 1288 0.394263814975732 460 2829742
SGTC_2349 9023730 187.07 µM 0.266958893742649 0.397298668655897 no 1289 0.39475040541609 420 4126287
SGTC_743 1275-0778 158 µM 0.265880721657134 0.397682639098572 no 1290 0.395165536376465 434 2849257 YMR203W TOM40
SGTC_502 l-744,832 89.3 µM 0.265596671246888 0.397783814755473 no 1291 0.395274924755472 456 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3114 9122766 49.47 µM 0.264837033053889 0.398054423353082 no 1292 0.395567503462167 396 17176985
SGTC_2561 acetosyringone 100 µM 0.263106533369572 0.398671068306931 no 1293 0.396234234204797 453 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_363 0455-0021 3.06 µM 0.262417713848793 0.398916592232057 no 1294 0.39649970870047 434 4597466
SGTC_1707 st032323 6.317 µM 0.261703261483716 0.39917129503157 no 1295 0.396775112924409 417 3132057 YMR211W DML1
SGTC_1096 rimcazole 32.2 µM 0.259004137735563 0.40013392126015 no 1296 0.397816023977206 451 18528119 A dopamine reuptake inhibitor.
SGTC_815 1582-0027 36.9 µM 0.255625900349624 0.401339604134761 no 1297 0.399119858561956 430 3128206
SGTC_809 3998-0021 90 µM 0.254444957559612 0.401761301431525 no 1298 0.39957591120608 459 715485
SGTC_2675 theaflavin digallate 100 µM 0.253076265762251 0.402250184251912 no 1299 0.40010463958571 427 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2365 9042475 200 µM 0.253040530713767 0.402262950500647 no 1300 0.40011844656414 411 6464479
SGTC_995 3931-2021 34.6 µM 0.252425791471778 0.402482580731926 no 1301 0.400355983375776 432 730143
SGTC_2960 9079389 5.97 µM 0.251112881216119 0.402951752181818 no 1302 0.400863418577549 427 16457355
SGTC_2141 5621638 7.665 µM 0.248351079410673 0.403939143786259 no 1303 0.401931390481037 438 2856238
SGTC_2903 5923464 63.88 µM 0.247894933942506 0.404102282722508 no 1304 0.402107849861915 437 2876576
SGTC_2051 5263410 176 µM 0.247185629624531 0.404355996218721 no 1305 0.402382283096939 426 227584
SGTC_1323 1348-1351 11.2 µM 0.247166990470648 0.404362663864569 no 1306 0.402389495324214 457 6989654
SGTC_2152 5568786 200 µM 0.247001267890709 0.40442194779139 no 1307 0.402453621418448 453 5399883
SGTC_3189 9110682 49.47 µM 0.246777779909463 0.404501899606275 no 1308 0.402540103901361 432 17122418
SGTC_955 1216-0110 33 µM 0.246256875210855 0.404688266381744 no 1309 0.402741695359442 429 3619719
SGTC_1311 1190-0148 100 µM 0.244795690171533 0.405211157406443 no 1310 0.40330731557837 440 1961333
SGTC_1368 1852-0141 284 µM 0.244323315790003 0.405380234751684 no 1311 0.403490213581077 422 2838987
SGTC_102 gallobenzophenone 83.616 µM 0.244088617362156 0.405464247118573 no 1312 0.403581094002477 438 70837
SGTC_3013 9080133 71.4286 µM 0.243321780612305 0.405738773423356 no 1313 0.403878066421135 413 17050193
SGTC_3227 9130768 49.47 µM 0.243160623000163 0.405796473485982 no 1314 0.403940484887577 454 17720899
SGTC_1969 st069479 40.1 µM 0.243004542145504 0.40585235784284 no 1315 0.404000939390658 463 3895485
SGTC_740 k014-0057 261 µM 0.241136622259612 0.406521310423549 no 1316 0.404724614810539 461 4012779
SGTC_2779 methotrexate 400 µM 0.239784214583472 0.407005814595001 no 1317 0.405248772480187 456 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3321 9137793 26.8275 µM 0.239582779629208 0.407077991479039 no 1318 0.405326857942493 438 4904192
SGTC_2418 pentamidine 31.67 µM 0.236838163336048 0.408061738266607 no 1319 0.4063911718121 438 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_554 4483-2211 187 µM 0.236674441210828 0.408120439214784 no 1320 0.406454682317067 426 747107
SGTC_1941 st076221 61.8 µM 0.236525009821003 0.408174018161236 no 1321 0.40651265135895 414 2828568
SGTC_2137 5261020 140 µM 0.235161511286595 0.408662982681473 no 1322 0.40704168895495 435 763655
SGTC_1804 st050076 49.1 µM 0.234597849767782 0.408865159056033 no 1323 0.407260439310261 450 3895976
SGTC_587 k089-0003 57 µM 0.231059406934259 0.410134893819773 no 1324 0.408634325200631 467 9659696
SGTC_1750 st081859 2.357 µM 0.230774035621527 0.410237337715347 no 1325 0.408745176691067 447 5291695
SGTC_2475 5812728 15.03 µM 0.229786861430522 0.410591765215295 no 1326 0.409128697314037 423 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2069 5228469 200 µM 0.22978102589352 0.410593860579431 no 1327 0.40913096469959 444 2835210
SGTC_611 3453-1652 23.7 µM 0.229703219061632 0.410621798893903 no 1328 0.409161196669959 434 1560575
SGTC_701 4424-0219 185 µM 0.229170175727196 0.410813212428169 no 1329 0.409368326041279 433 2911779
SGTC_770 0389-1121 67.2 µM 0.228703078968122 0.410980962298488 no 1330 0.40954985077123 423 6753108
SGTC_823 0417-1665 178 µM 0.226201034553513 0.411879805514228 no 1331 0.410522533003102 458 3429856
SGTC_559 1550-0661 158 µM 0.225945035954494 0.411971797512673 no 1332 0.41062208488431 453 5830875
SGTC_669 0108-0021 26.2 µM 0.225768187144692 0.41203535019954 no 1333 0.410690860622951 443 17201
SGTC_832 4083-0019 164 µM 0.225706928125484 0.412057364882184 no 1334 0.410714684631508 425 1990758
SGTC_2414 st077232 92.9 µM 0.225077298009952 0.412283651382676 no 1335 0.410959570724915 383 729801
SGTC_1098 clofazimine 15.1 µM 0.224330929175165 0.412551931074191 no 1336 0.411249905707887 439 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_466 geldanamycin 89.2 µM 0.224233996209411 0.412586776293339 no 1337 0.411287615877904 444 5288382 HSP90 inhibitor.
SGTC_1370 2001-0092 44.6 µM 0.224134817971826 0.412622429350205 no 1338 0.411326200382219 466 790957
SGTC_2531 methyl deoxycholate 70.07 µM 0.223285203149492 0.412927882372649 no 1339 0.411656771378303 444 16667744 Haematoxylin.
SGTC_2836 9010338 19.48 µM 0.222995105583953 0.41303219016335 no 1340 0.411769657890647 431 2994051
SGTC_3098 9119039 49.47 µM 0.222615579195921 0.413168662346852 no 1341 0.411917355127111 436 17161528
SGTC_852 0418-0143 439 µM 0.22258099586306 0.413181098533545 no 1342 0.411930814265706 438 5369229
SGTC_654 1124-0271 80.9 µM 0.222449014059986 0.413228560067522 no 1343 0.411982179884827 450 5403748
SGTC_2346 9031566 143.75 µM 0.222422758043266 0.413238002056972 no 1344 0.411992398568489 449 4771086
SGTC_962 1254-0300 21.5 µM 0.22082004912607 0.413814450894224 no 1345 0.41261627597903 429 7340576
SGTC_2956 9076196 2.52 µM 0.220769304494531 0.413832705336146 no 1346 0.412636032668708 483 16423868
SGTC_3138 9097216 49.47 µM 0.220758630593718 0.413836545098094 no 1347 0.412640188426064 466 25237486
SGTC_64 000l-0018 272.079 µM 0.220013323556823 0.414104677514075 no 1348 0.412930389116281 420 6811119
SGTC_1149 3909-7961 23.3 µM 0.219334496529454 0.414348927862877 no 1349 0.41319474585767 432 735261
SGTC_2835 9006588 71.43 µM 0.219014934357838 0.414463921752947 no 1350 0.413319207121056 382 2345538
SGTC_597 k018-0003 82.8 µM 0.218987942649472 0.414473635008051 no 1351 0.413329720097785 458 6786234
SGTC_201 4262-0159 12.803 µM 0.217604913833965 0.414971402596136 no 1352 0.413868477775641 459 1341029
SGTC_2444 5485484 36.41 µM 0.216394422734247 0.415407184003319 no 1353 0.414340156650602 450 6790631
SGTC_2673 kobusone 100 µM 0.215886394099661 0.415590107283381 no 1354 0.414538151483079 459 6710676 An epoxy ketone and protein crosslinker.
SGTC_2580 diallyl disulphide 81.36 µM 0.215882428844005 0.415591535104767 no 1355 0.414539696954141 450 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1261 0712-0010 12.7 µM 0.21488266558335 0.415951568432447 no 1356 0.414929400034936 461 2840123
SGTC_2215 7188065 200 µM 0.213759200858177 0.416356233129008 no 1357 0.41536742126483 466 940217
SGTC_3155 9099265 49.47 µM 0.21358119490954 0.416420357864364 no 1358 0.415436832653634 457 25236499
SGTC_1855 st056195 39.6 µM 0.213453876128483 0.416466224455447 no 1359 0.415486480778646 436 4028379
SGTC_818 4072-2707 53.5 µM 0.210979799421476 0.41735773565408 no 1360 0.416451517146814 428 882871
SGTC_1951 sophoraflavanone G 9.2 µM 0.210656250317583 0.417474355174853 no 1361 0.416577757825686 441 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2856 9022925 19.48 µM 0.209894547945145 0.417748930602033 no 1362 0.416874988781017 431 4944862
SGTC_295 k015-0027 31 µM 0.209688367986921 0.417823260431714 no 1363 0.416955452356877 436 3887424
SGTC_3037 9091026 49.47 µM 0.209442821918946 0.417911785947069 no 1364 0.417051283448 442 25236398 YIL048W NEO1
SGTC_873 0591-4978 488 µM 0.20798991197369 0.418435681394377 no 1365 0.417618422097123 477 3305145
SGTC_2677 mitomycin C 100 µM 0.206846600739908 0.418848042434273 no 1366 0.418064830471363 440 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2939 9044578 71.43 µM 0.206185078490843 0.419086676142507 no 1367 0.418323171536703 443 2653634
SGTC_1040 k898-0338 155 µM 0.205415880415687 0.419364189632788 no 1368 0.418623607020827 459 20969351
SGTC_1353 1498-1206 8.11 µM 0.205118987158253 0.41947131437236 no 1369 0.418739581107478 458 6756808
SGTC_1077 5-fluorocytosine 377 nM 0.204829989760356 0.419575595868344 no 1370 0.41885247765348 469 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1239 0337-0584 35.4 µM 0.204803781832489 0.419585052987004 no 1371 0.418862716085079 463 914301 YML130C ERO1
SGTC_1304 1165-0502 251 µM 0.204720779831206 0.41961500452727 no 1372 0.418895142144092 429 767425
SGTC_1939 st074455 53.6 µM 0.203031451525363 0.420224705061896 no 1373 0.419555224688381 481 1644229
SGTC_2949 9072542 2.23 µM 0.202449102015812 0.420434927021305 no 1374 0.419782822580914 429 16457352
SGTC_2479 5617353 43.85 µM 0.201668652268405 0.420716696634226 no 1375 0.420087885455118 466 2731746
SGTC_2641 levomentholum 100 µM 0.201424657728105 0.420804795526109 no 1376 0.420183268113748 475 16666
SGTC_2317 5986382 200 µM 0.200753690096522 0.42104708165049 no 1377 0.420445587795046 467 877883
SGTC_107 0358-0022 2.6945 µM 0.200594020037122 0.421104742848869 no 1378 0.420508017176743 467 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.200143921467418 0.421267294781454 no 1379 0.420684011932725 468 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_862 0452-0056 10.2 µM 0.19920375902248 0.421606875275577 no 1380 0.421051679538306 451 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3199 9111318 49.47 µM 0.198445815516153 0.421880681951032 no 1381 0.421348137269405 455 8548020
SGTC_2495 cafestol 54.53 µM 0.195729777562698 0.422862158417549 no 1382 0.422410838030108 457 16667697 An anti-infammatory.
SGTC_2312 7706453 155.7 µM 0.195166585502225 0.423065735526901 no 1383 0.422631268466925 454 976098
SGTC_1071 trifluoperazine 6.31 µM 0.193905425986387 0.423521681459406 no 1384 0.423124967507391 471 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2393 9031399 185.94 µM 0.193740674219662 0.423581251603115 no 1385 0.423189470890604 449 1526623 YDL150W RPC53
SGTC_2247 cerulenin 830 nM 0.192225192041693 0.424129294046448 no 1386 0.423782906731361 474 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1438 4092-1045 4 µM 0.188097192201862 0.4256228401627 no 1387 0.425400231056051 454 1351342
SGTC_3017 9080681 49.47 µM 0.187339886335085 0.425896956537555 no 1388 0.425697075885292 468 16451914
SGTC_2733 amorolfine 100 µM 0.187043880298069 0.42600410938425 no 1389 0.425813114255275 486 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_144 4161-2749 112.381 µM 0.186115707572574 0.426340139104166 no 1390 0.426177012130052 451 797501 YMR168C CEP3
SGTC_1310 1188-0297 994 nM 0.185887856110252 0.426422637176216 no 1391 0.426266352822705 458 1588352
SGTC_1300 1094-0077 113 µM 0.185887052954163 0.42642292798026 no 1392 0.426266667747376 450 5532636
SGTC_1946 st076057 65.1 µM 0.185829198260871 0.426443875917453 no 1393 0.426289353212675 466 953009
SGTC_2476 5806916 10.51 µM 0.183938968431763 0.427128401196557 no 1394 0.427030666973239 474 2870194
SGTC_2644 guaiazulene 100 µM 0.183797935902739 0.427179483350454 no 1395 0.427085987732313 466 3515 A coloring agent.
SGTC_2071 5230951 39.92 µM 0.182297867204215 0.427722885458049 no 1396 0.427674486183032 479 1799272
SGTC_2297 7971671 152.32 µM 0.178743382062068 0.429011048575966 no 1397 0.429069601862139 451 909016
SGTC_1131 3454-3128 32.3 µM 0.178701531092756 0.42902622010824 no 1398 0.429086033449924 432 710982
SGTC_3327 9140648 26.9345 µM 0.1786602266059 0.429041193636178 no 1399 0.429102250597473 478 8029710
SGTC_1052 3253-3998 198 µM 0.178440398659083 0.429120886451448 no 1400 0.429188562416217 442 5450317
SGTC_386 1509-0011 3.07 µM 0.178060447755037 0.429258634425833 no 1401 0.429337751854873 466 3107280
SGTC_116 0155-0182 31.788 µM 0.177652931990375 0.429406385380947 no 1402 0.429497775978614 443 771486
SGTC_1649 st011737 51.3 µM 0.177285163293295 0.429539733930905 no 1403 0.429642202088993 470 1761035
SGTC_2007 4011539 71.82 µM 0.176872040640969 0.429689536872446 no 1404 0.429804450339389 466 45595301
SGTC_976 1348-1067 47.6 µM 0.176393895668824 0.429862930280019 no 1405 0.42999225001329 442 5310671 YGL099W LSG1
SGTC_3213 9129884 49.47 µM 0.176287497544839 0.429901516095592 no 1406 0.430034041865225 430 17190742
SGTC_2043 5101342 149 µM 0.174962379629346 0.430382132762599 no 1407 0.430554597132554 456 678451
SGTC_2792 7535235 81.82 µM 0.169439626532815 0.432386323245596 no 1408 0.432725428311985 445 1281891
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.168846134533428 0.432601804217816 no 1409 0.432958834569344 479 5355888
SGTC_2665 lovastatin 100 µM 0.166654233472375 0.433397797742353 no 1410 0.433821059106597 454 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1025 k007-0731 70 µM 0.16655504496483 0.433433824674916 no 1411 0.433860084208191 470 6256118
SGTC_1255 0566-0045 221 µM 0.164276376997512 0.434261626890205 no 1412 0.434756788732998 469 2788469
SGTC_1287 0971-0001 34.6 µM 0.164221957833922 0.434281400007939 no 1413 0.434778207959126 453 4665869
SGTC_2940 9060638 45.86 µM 0.16352264234168 0.434535509810144 no 1414 0.435053473537172 445 4027022
SGTC_429 1112-0049 25.5 µM 0.162491292806628 0.434910319931048 no 1415 0.43545949224614 423 2836170
SGTC_1249 0481-0015 10.2 µM 0.162073966295509 0.43506200019091 no 1416 0.435623803505094 491 4227577
SGTC_2436 5633522 8.09 µM 0.161877605978845 0.435133372038508 no 1417 0.435701119024925 462 5724242
SGTC_40 0327-0103 19.753 µM 0.161481514043862 0.435277347542772 no 1418 0.435857084967053 455 409036
SGTC_2166 5933061 31.504 µM 0.16003065451969 0.435804793780134 no 1419 0.436428463292733 454 2877375
SGTC_1891 st059073 26.2 µM 0.159911702391909 0.43584804277758 no 1420 0.436475314988415 496 688754
SGTC_595 3909-8003 73.7 µM 0.15988850294865 0.435856477795243 no 1421 0.436484452661126 481 699517
SGTC_2943 9068529 45.32 µM 0.159751207391219 0.435906397282227 no 1422 0.436538530595139 496 3270634
SGTC_2924 9010168 62.78 µM 0.159131995664685 0.436131550030988 no 1423 0.436782440252344 452 2993929
SGTC_2652 actinonin 100 µM 0.159087996146116 0.436147549567772 no 1424 0.436799772731748 478 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1103 duloxetine 36.1 µM 0.159032457079873 0.436167745377318 no 1425 0.436821651092574 454 60835 A selective serotonin reuptake inhibitor.
SGTC_3124 9127567 49.47 µM 0.158382097552521 0.436404249609636 no 1426 0.437077859903238 466 17592030
SGTC_938 3126-1755 342 µM 0.158047601253879 0.43652589855782 no 1427 0.43720964483739 485 1777771
SGTC_1097 itavastatin 7.23 µM 0.155604823735566 0.437414464312837 no 1428 0.438172261235428 490 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3161 9100388 49.47 µM 0.155226942254809 0.437551947854676 no 1429 0.438321204434075 477 25236368
SGTC_1924 st058459 75.1 µM 0.154801271926994 0.437706827306346 no 1430 0.438488994223252 495 688683
SGTC_3345 9148410 3.559 µM 0.153941033683357 0.438019852692325 no 1431 0.438828114752826 489 4903596
SGTC_262 fenpropimorph 62.5 µM 0.153029761575605 0.438351490695963 no 1432 0.439187402680255 480 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2314 7727897 200 µM 0.151662901497755 0.438849011307414 no 1433 0.439726409467316 462 900724
SGTC_2866 9034245 58.44 µM 0.148065653457885 0.44015882609599 no 1434 0.441145477595829 481 6462273
SGTC_1444 4112-3581 28 µM 0.146033050083156 0.440899219678089 no 1435 0.441947648949869 479 2877249
SGTC_1056 3448-1962 115 µM 0.145348652291802 0.441148564197971 no 1436 0.442217801783819 470 715507
SGTC_1262 0737-0114 49.6 µM 0.145238750561381 0.441188606530346 no 1437 0.442261185880723 499 765919
SGTC_1636 st007707 68.9 µM 0.144464904137017 0.441470571915636 no 1438 0.442566684070207 500 403051
SGTC_459 nigericin 15.3 µM 0.143879004710969 0.441684075046091 no 1439 0.442798007491506 483 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3123 9126162 49.47 µM 0.142269722330835 0.442270588341289 no 1440 0.443433480652179 491 25239884
SGTC_2769 toremifene 3.73 µM 0.141821164666373 0.442434090672373 no 1441 0.44361063302925 481 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_964 1287-0107 19.4 µM 0.141389496891187 0.442591445782844 no 1442 0.443781125592385 497 51516812 YPR165W RHO1
SGTC_1736 st036774 51 µM 0.141231373397675 0.442649088535272 no 1443 0.443843581040879 492 1272247
SGTC_849 0386-0493 241 µM 0.140679745616962 0.442850189868694 no 1444 0.44406147330253 473 726119
SGTC_3337 9144342 33.5465 µM 0.140117274727533 0.443055259325076 no 1445 0.44428366598926 486 17682949
SGTC_1644 st010134 20.9 µM 0.139397598617982 0.443317665966666 no 1446 0.44456798492978 500 3818134
SGTC_1395 3486-0190 4.35 µM 0.138906372227569 0.443496790081347 no 1447 0.444762067739306 483 6748079
SGTC_1301 naphtanilide LB 4.81 µM 0.138331814384945 0.44370631538821 no 1448 0.444989091481331 487 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1282 0886-0010 32.4 µM 0.138054414037939 0.443807481236643 no 1449 0.445098706517239 505 2836211 YNL267W PIK1
SGTC_2618 avocadyne 43.43 µM 0.136563735154632 0.444351183317125 no 1450 0.445687821514735 484 3015189
SGTC_2933 9026794 32.47 µM 0.136182232983599 0.444490347210005 no 1451 0.445838610167668 491 17586027
SGTC_2817 7995342 71.43 µM 0.135442564125624 0.44476018218759 no 1452 0.446130986428549 468 18879975
SGTC_3167 9103034 49.47 µM 0.134805728721757 0.444992523509927 no 1453 0.446382738160756 455 5127859
SGTC_3313 9133968 57.047 µM 0.133754368300514 0.445376140345484 no 1454 0.446798405842756 501 1494643
SGTC_1696 st025591 34.7925 µM 0.133299442986101 0.445542147832643 no 1455 0.446978284051248 463 2787147
SGTC_261 5-fluorouridine 15.376 µM 0.1325758240448 0.445806224381501 no 1456 0.447264426616871 469 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2820 7989630 71.43 µM 0.132275157279063 0.445915956394548 no 1457 0.44738332815842 494 2984098
SGTC_3151 9099821 49.47 µM 0.132074408608208 0.445989224383865 no 1458 0.447462718769304 471 17174189
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.131678459148923 0.44613374093512 no 1459 0.447619312122551 471 390807
SGTC_2786 7743617 45.45 µM 0.131291879166903 0.446274844649543 no 1460 0.447772207835105 471 583674
SGTC_946 3434-1334 87.4 µM 0.131060545472601 0.446359285912302 no 1461 0.447863706016579 473 4047976
SGTC_3326 9140064 16.379 µM 0.131048764946095 0.446363586096945 no 1462 0.447868365579629 470 1868434
SGTC_1526 st051518 75 µM 0.13042458185838 0.446591437428958 no 1463 0.448115259592558 458 673993
SGTC_2134 5324836 1.464 µM 0.12969552251745 0.446857595032517 no 1464 0.448403662580447 515 699272
SGTC_2702 st077768 96.8 µM 0.129519542665511 0.446921843566389 no 1465 0.44847328119069 467 6484119
SGTC_483 fpl-64176 144 µM 0.129464356545334 0.446941991769612 no 1466 0.448495113454343 500 3423
SGTC_1764 st044502 93.5 µM 0.128866324527365 0.447160339330629 no 1467 0.448731711786856 459 8407
SGTC_1454 4239-0054 42.6 µM 0.128818984852167 0.447177624211617 no 1468 0.448750441477409 515 1340767
SGTC_2776 terbinafine 19.92 µM 0.126407628037857 0.448058201957169 no 1469 0.449704632144371 486 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3164 9100705 49.47 µM 0.125777497318597 0.448288355060637 no 1470 0.449954027415503 492 17174235
SGTC_2148 5546263 113.568 µM 0.124821100836833 0.448637708859458 no 1471 0.450332590992256 472 792097
SGTC_2589 lobaric acid 100 µM 0.123746054489738 0.449030450778639 no 1472 0.450758172832601 473 73157 A novel microtubule depolymerizer.
SGTC_511 blebbistatin 171 µM 0.12369791938094 0.449048036935775 no 1473 0.450777229551265 481 3476986 A myosin inhibitor.
SGTC_1953 st076800 12.1 µM 0.12293969357773 0.449325067841264 no 1474 0.451077426547686 461 297591
SGTC_1351 1496-0003 46.5 µM 0.122181569551657 0.449602086259551 no 1475 0.451377611227324 489 3891978
SGTC_3282 9108498 15.4605 µM 0.122168317154649 0.449606928902489 no 1476 0.451382858857348 483 16459645
SGTC_2303 7774051 200 µM 0.120800762265539 0.450106696076235 no 1477 0.451924423163568 492 2953184
SGTC_1785 bathophenanthroline 24 µM 0.120595118890696 0.450181854445293 no 1478 0.45200586759356 479 72812 An iron chelator.
SGTC_2000 st075254 36.4 µM 0.117919997049799 0.451159717573411 no 1479 0.453065524219234 461 17234175
SGTC_1847 st056231 15 µM 0.117789207211836 0.451207534096245 no 1480 0.45311734070502 469 5393180
SGTC_2958 9077254 16.72 µM 0.114484400365034 0.45241599849434 no 1481 0.454426905897705 481 16457351
SGTC_2662 daunorubicin 22.37 µM 0.114085831063193 0.452561772827325 no 1482 0.454584877029518 486 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1180 1193-0155 285 µM 0.113638260707162 0.452725476623174 no 1483 0.454762278067573 488 2921347
SGTC_1418 3966-3099 2.4 µM 0.112645601664477 0.453088581255658 no 1484 0.455155765103674 505 740335
SGTC_1700 st030840 7.9285 µM 0.111958091356426 0.45334008857988 no 1485 0.455428317920338 483 5499307
SGTC_2323 6148992 148.28 µM 0.111704625309625 0.453432817105814 no 1486 0.455528805909968 467 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2066 5222451 176 µM 0.110943642968438 0.453711231643117 no 1487 0.455830518556961 509 2281147
SGTC_2607 solasodine 47.35 µM 0.110614656080352 0.45383160250256 no 1488 0.455960962469902 483 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2160 5660466 132.927 µM 0.110472771132211 0.453883517167284 no 1489 0.456017221581644 511 2859134
SGTC_3328 9140624 29.0385 µM 0.110359709304814 0.453924886227113 no 1490 0.456062052605987 507 4904392
SGTC_2244 6635614 200 µM 0.109739603422181 0.454151790406016 no 1491 0.456307945543893 496 836499
SGTC_878 0828-0289 13.7 µM 0.109524394602832 0.454230541395458 no 1492 0.456393287029596 475 745350 YLR208W SEC13
SGTC_1109 tnp00067 928.257 nM 0.108273338711445 0.454688373639445 no 1493 0.456889435445517 497 676295
SGTC_318 1488-0629 67.2 µM 0.107884512474392 0.45483067948428 no 1494 0.45704365133276 489 3662576
SGTC_500 h-89 112 µM 0.107671845647714 0.454908515503526 no 1495 0.457128001782775 489 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_898 1000-0849 28.3 µM 0.106874093933635 0.455200507886788 no 1496 0.457444432751454 497 6751807
SGTC_1676 st018489 23.4 µM 0.105743271161842 0.455614452082182 no 1497 0.457893023684185 516 3696235
SGTC_1108 betulinic acid 729.144 nM 0.104135162687614 0.456203192343759 no 1498 0.458531043375608 460 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2302 7771753 200 µM 0.103254271517211 0.456525733888166 no 1499 0.458880583802739 497 2203047
SGTC_3221 9128209 49.47 µM 0.103056780759745 0.45659804979455 no 1500 0.458958953138042 507 16460723
SGTC_411 enrofloxacin 100 µM 0.100051958460291 0.457698512399167 no 1501 0.460151537733387 508 71188 A bacterial gyrase inhibitor.
SGTC_209 4077-0173 175.592 µM 0.0993093864039681 0.457970516491849 no 1502 0.460446312993932 498 15993494
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0988660300890374 0.458132927272566 no 1503 0.460622320394198 514 5106787 A p450 inhibitor.
SGTC_365 0121-0052 13.6 µM 0.0982836038601008 0.458346292918652 no 1504 0.460853548683375 490 3101739
SGTC_1628 st004252 77.7 µM 0.0974508261918976 0.45865139298327 no 1505 0.461184191650454 490 692968
SGTC_2686 alizarin 95.37 µM 0.0973294353446266 0.458695868302879 no 1506 0.461232390470001 471 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_244 nsc-207895 1.295 µM 0.0967522860987222 0.458907331977516 no 1507 0.461461558131099 492 42640
SGTC_2095 5432005 200 µM 0.0949284151067108 0.459575662427915 no 1508 0.462185843219313 521 783734
SGTC_1280 0880-0253 10.1 µM 0.0932666730898309 0.460184682639257 no 1509 0.46284585383398 505 6836607
SGTC_2657 nystatin 74.44 µM 0.0917495184978366 0.460740793895582 no 1510 0.463448526603328 504 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0906196444989549 0.461154997849679 no 1511 0.463897411051178 486 165521
SGTC_3049 9092223 49.47 µM 0.0893487410763335 0.461620952551446 no 1512 0.464402379578662 499 8623917
SGTC_3020 9089140 49.47 µM 0.0891114679273278 0.461707950492562 no 1513 0.464496661783478 497 17217859
SGTC_1675 st018485 24.5 µM 0.0890711076112313 0.461722749081066 no 1514 0.464512699446025 517 3323024
SGTC_3018 9082602 49.47 µM 0.0885029724724555 0.461931068180931 no 1515 0.464738460960183 497 17332089
SGTC_2315 7733312 200 µM 0.0878341992808375 0.462176301789568 no 1516 0.465004227851252 475 726316
SGTC_3285 9112818 20.8695 µM 0.084986172414104 0.463220809610306 no 1517 0.466136191875176 510 17017947 YPR165W RHO1
SGTC_2886 9058944 51.95 µM 0.0848059630917329 0.463286909604341 no 1518 0.466207826380198 515 4949929
SGTC_2313 7726885 200 µM 0.0840951700554835 0.463547635258207 no 1519 0.46649038239007 505 726423
SGTC_1191 1487-1166 10.6 µM 0.0835027069839107 0.463764968323598 no 1520 0.466725912524782 517 3955771
SGTC_1209 2323-2347 50.3 µM 0.0832848517997301 0.463844886803475 no 1521 0.466812522478928 507 5412760
SGTC_3093 9117344 49.47 µM 0.0831119350624992 0.463908321002328 no 1522 0.466881267937016 512 24824913
SGTC_2640 pentamidine 10.38 µM 0.0818733016260661 0.464362738214474 no 1523 0.467373732680269 503 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_992 3909-8734 162 µM 0.0818691234994205 0.464364271122002 no 1524 0.467375393934694 501 4288319
SGTC_1762 st045503 25.4615 µM 0.0813291404621652 0.464562389249859 no 1525 0.467590100003757 502 4645554
SGTC_1339 1486-1321 22.7 µM 0.0801458693426684 0.464996558465078 no 1526 0.468060620797874 496 3469382
SGTC_1684 st024538 14.6195 µM 0.0793384360080698 0.465292848161317 no 1527 0.468381717563504 517 6732859
SGTC_1957 st077035 62.4 µM 0.0785669263783051 0.465575973542999 no 1528 0.468688547558757 518 705593
SGTC_2133 5320837 200 µM 0.0768477733419882 0.466206923610422 no 1529 0.469372322722812 504 2841355
SGTC_1031 k035-0009 16 µM 0.0755217174828789 0.466693660347103 no 1530 0.469899809412451 517 5180959
SGTC_2833 9001315 45.46 µM 0.0747310514653566 0.466983902792065 no 1531 0.470214350623574 514 2989378
SGTC_2671 danthron 100 µM 0.0742841743434444 0.467147952913541 no 1532 0.470392134640965 507 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2014 4013930 200 µM 0.074060913301921 0.467229914898515 no 1533 0.470480958238993 510 64556
SGTC_2309 7664088 163.95 µM 0.0739338929047787 0.467276546331886 no 1534 0.470531493500449 510 704922
SGTC_1267 0828-0272 9.49 µM 0.0738636171933736 0.467302345980955 no 1535 0.470559453004894 500 745334
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0727465862186259 0.467712449240032 no 1536 0.471003888143808 503 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2795 7780010 54.55 µM 0.0724822352687792 0.467809507252279 no 1537 0.471109071240903 502 953673
SGTC_1749 st037932 54.2 µM 0.0717889353786354 0.468064065477016 no 1538 0.471384939194719 510 594497
SGTC_34 0469-0683 81.75 µM 0.0715543853119427 0.468150187951092 no 1539 0.471478271109927 509 3690923
SGTC_2724 maprotiline 69.64 µM 0.0706042609919921 0.468499071348306 no 1540 0.47185635954876 521 4011 A tricyclic antidepressant.
SGTC_1464 k208-0027 110 µM 0.0698205135396487 0.468786879775786 no 1541 0.472168259788734 523 X1464
SGTC_428 3448-4153 16.5 µM 0.0683322490614909 0.469333446339021 no 1542 0.472760576538465 505 3834874
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0673590875823627 0.469690872145295 no 1543 0.473147919280194 519 6708514
SGTC_2859 9028643 45.46 µM 0.0670538452682701 0.469802987547198 no 1544 0.473269418645868 502 17151580
SGTC_2021 4019055 173 µM 0.0670527512231754 0.469803389393913 no 1545 0.47326985412662 514 44827708 YER133W GLC7
SGTC_902 1120-0002 2.07 µM 0.0654447803399493 0.470394035933593 no 1546 0.473909935460317 506 3280475
SGTC_1779 st039427 55 µM 0.0632946454993701 0.471183933951914 no 1547 0.474765939744228 513 1124498
SGTC_2377 9073351 62.6 µM 0.0621852954669826 0.471591521946525 no 1548 0.47520763617158 512 7337946 YHR072W ERG7
SGTC_1186 1319-0216 26 µM 0.0621012476850049 0.47162240328878 no 1549 0.475241101704582 518 4565136
SGTC_2861 9024595 19.48 µM 0.0620819478222129 0.4716294945847 no 1550 0.475248786407894 530 16482810
SGTC_3119 9125183 49.47 µM 0.0613620668441488 0.471894004893161 no 1551 0.475535430839181 523 22695334
SGTC_409 arachidonic acid 100 µM 0.0601165841654487 0.472351669488673 no 1552 0.476031390798887 516 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3179 9107801 49.47 µM 0.0596100313464074 0.472537817673831 no 1553 0.476233114359637 504 4818259
SGTC_2549 cedrol 20.94 µM 0.0595079033837222 0.472575348416726 no 1554 0.476273785322482 513 6708665 A sedative which affects the nervous system.
SGTC_2368 9071271 200 µM 0.0587293089816777 0.47286148005501 no 1555 0.476583857215083 524 27209959
SGTC_677 0929-0063 136 µM 0.0586264307597107 0.472899288613805 no 1556 0.476624829091811 526 1539583
SGTC_177 1327-0068 8.361 µM 0.05846569249956 0.472958361682071 no 1557 0.476688844574671 512 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.0583580829275512 0.472997909708927 no 1558 0.476731701407645 521 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1375 2910-0797 186 µM 0.0575365238683656 0.473299852929819 no 1559 0.477058906222701 533 742508
SGTC_53 0973-0023 39.979 µM 0.0573374526993873 0.473373018810838 no 1560 0.477138193236529 520 674768
SGTC_786 4544-0069 423 µM 0.0569170909689127 0.473527519954329 no 1561 0.477305619879094 509 748821 YLR208W SEC13
SGTC_1718 roemerine 11.9335 µM 0.056664313777455 0.473620428439768 no 1562 0.47740630089964 514 235224 An aporphine alkaloid with mutagenic activity.
SGTC_581 0958-0271 211 µM 0.0565222990797777 0.473672626700268 no 1563 0.47746286591109 509 4591145
SGTC_1828 st055811 49 µM 0.0563838187043535 0.473723526337051 no 1564 0.477518023625365 529 5877589
SGTC_31 0508-1974 57.237 µM 0.0552968732264954 0.474123057200763 no 1565 0.477950976580349 521 6810525
SGTC_354 2783-3500 4.88 µM 0.0543761077782282 0.474461525296345 no 1566 0.478317756958522 526 6740761
SGTC_688 0527-0193 473 µM 0.0540432042769368 0.474583903263313 no 1567 0.478450371240724 532 4007154
SGTC_1120 ficusin 1.78878 µM 0.0538287461281102 0.474662741050256 no 1568 0.478535803308324 508 6199 A DNA cross-linker.
SGTC_1044 1222-0021 1.78 µM 0.053709346281299 0.474706634518457 no 1569 0.478583368148142 497 4306703
SGTC_1761 st044296 37 µM 0.0519426901162274 0.475356123759519 no 1570 0.479287179187107 514 1826700
SGTC_1771 st048882 4.1505 µM 0.0498171380793258 0.476137643264119 no 1571 0.480134054713719 528 4580403
SGTC_1978 st071761 42 µM 0.0497034765894265 0.476179436747726 no 1572 0.480179342984071 518 5147680
SGTC_171 k064-0041 9.68 µM 0.0490717598434864 0.476411724612749 no 1573 0.480431054332606 520 53325
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0488909222590929 0.476478221679865 no 1574 0.480503111600061 530 140250 A respiratory chain inhibitor.
SGTC_2201 6605497 169.863 µM 0.0470415496150519 0.477158304851337 no 1575 0.481240056181044 530 670741
SGTC_1152 3909-8331 15.9 µM 0.0469323527708185 0.477198462695785 no 1576 0.481283571356723 524 16001939
SGTC_664 1222-0054 14.9 µM 0.0467650845948025 0.47725997709626 no 1577 0.481350228514426 529 6813991
SGTC_3042 9091578 49.47 µM 0.0466992320415851 0.477284195123296 no 1578 0.481376471210879 528 25236497
SGTC_2049 5262831 67.185 µM 0.0463185595008556 0.477424193430461 no 1579 0.481528173420882 522 763417
SGTC_1724 st037281 8.293 µM 0.0459451872999846 0.477561509629584 no 1580 0.481676968963408 528 574124 YDL195W SEC31
SGTC_1616 st002734 56.1 µM 0.0455417922192957 0.477709870425552 no 1581 0.481837732031999 525 4026101
SGTC_3233 9132340 49.47 µM 0.0447219682898697 0.478011395078607 no 1582 0.482164461525821 533 17682950
SGTC_3239 9133757 49.47 µM 0.0439034143979847 0.478312465179902 no 1583 0.482490696815503 524 17036923
SGTC_3023 9089636 49.47 µM 0.0438721816685297 0.478323953052181 no 1584 0.482503144877691 538 17249241
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0432233094416978 0.478562622172171 no 1585 0.482761762101078 507 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_132 0417-1715 25.805 µM 0.0429425808541557 0.478665882554337 no 1586 0.482873652713068 533 6769098
SGTC_1747 st037496 66.6 µM 0.0428434216979427 0.47870235660436 no 1587 0.482913175119376 525 723305
SGTC_617 3770-0098 35 µM 0.0416182552954263 0.479153028354526 no 1588 0.483401510114151 532 5962639
SGTC_349 k015-0014 24 µM 0.0409601675177077 0.479395113916139 no 1589 0.483663825455382 524 2196908
SGTC_1510 1123-0200 71.5 µM 0.0395922354399678 0.479898348521754 no 1590 0.484209108904139 536 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3072 9116419 49.47 µM 0.0371368179358641 0.48080172691315 no 1591 0.485187957898682 522 17170162
SGTC_1837 st055472 66.5 µM 0.0354966012687959 0.481405238079465 no 1592 0.485841878231848 510 676091
SGTC_453 enantio-paf c16 10 µM 0.0347049322520317 0.481696544864429 no 1593 0.486157513964894 531 13871343 A lipid and platelet activating factor
SGTC_2680 butyl paraben 22.24 µM 0.0338680435808608 0.48200450153972 no 1594 0.486491188044936 536 7184 An antifungal and steroid mimetic.
SGTC_2843 9000894 45.46 µM 0.0336040494544347 0.482101647824591 no 1595 0.486596446547946 532 2242070
SGTC_3048 9093155 49.47 µM 0.0335535780121469 0.482120220757141 no 1596 0.48661657039184 534 25236002
SGTC_3251 9135047 49.47 µM 0.033437047597128 0.482163102809207 no 1597 0.486663033229841 529 17682963
SGTC_3242 9133940 49.47 µM 0.0321832423084948 0.482624503835639 no 1598 0.487162959978732 529 17248444
SGTC_214 4373-3496 70 µM 0.0319584582008068 0.482707226987259 no 1599 0.487252589757327 531 3779166
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0315522077312013 0.482856733745156 no 1600 0.487414578549535 525 1273210
SGTC_796 1234-0020 70.7 µM 0.0309334131469818 0.483084464807839 no 1601 0.487661321414253 536 46495034
SGTC_551 k048-0028 34.9 µM 0.0306351248892258 0.483194243927353 no 1602 0.487780264838594 536 6836383
SGTC_1812 st052057 4.327 µM 0.0303576787345891 0.483296353665056 no 1603 0.487890898381609 525 3645418
SGTC_2395 5646831 180.19 µM 0.0302238162341485 0.483345620066486 no 1604 0.487944277298775 532 6808628
SGTC_1332 1480-0653 17.5 µM 0.0295120144949295 0.483607593953112 no 1605 0.488228118467312 540 5749438
SGTC_659 k018-0002 107 µM 0.0283262372359772 0.484044027029763 no 1606 0.488700977352321 527 6797879 YHR007C ERG11
SGTC_2207 7258803 200 µM 0.0281168552246164 0.484121093449419 no 1607 0.488784475431375 533 3666799
SGTC_2798 7813637 45.45 µM 0.0278981416157684 0.484201595147127 no 1608 0.488871695321848 536 956368
SGTC_2237 6667747 47.222 µM 0.0276851492619352 0.484279991647207 no 1609 0.488956634168355 538 729940 YDL015C TSC13
SGTC_1911 st060208 74.3 µM 0.0276320108802205 0.484299550487092 no 1610 0.488977825208439 526 688783
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0275119343755897 0.484343747627493 no 1611 0.489025710597966 532 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2793 7325131 81.82 µM 0.0259273646312927 0.484927005696156 no 1612 0.489657636780271 530 4176441
SGTC_2468 5987765 72.9 µM 0.0258918614953419 0.484940074280408 no 1613 0.489671795728982 525 26772094
SGTC_570 0987-0065 62.6 µM 0.0251662730927764 0.485207164440682 no 1614 0.489961169302029 537 3104428
SGTC_3329 9141233 27.5565 µM 0.0250040483976661 0.485266880502045 no 1615 0.490025867232479 541 4909101 YNL103W MET4
SGTC_3335 9143315 29.6265 µM 0.0248045413721917 0.485340320906657 no 1616 0.490105434341509 536 4899691
SGTC_1938 st074717 56.4 µM 0.0246353794040459 0.485402591401109 no 1617 0.490172899586397 539 17250979
SGTC_1683 st010134 710 nM 0.0227414224393834 0.486099803012153 no 1618 0.490928267020693 532 3818134
SGTC_2276 7947513 42.08 µM 0.0215931160348571 0.486522543348837 no 1619 0.491386262430648 518 2105100
SGTC_389 tpck 16.7 µM 0.0210419611845049 0.486725452255952 no 1620 0.491606091445776 525 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1020 4335-0961 93.3 µM 0.0205239941111861 0.486916146141142 no 1621 0.491812685786681 532 669075
SGTC_147 4466-0538 29.23 µM 0.0196651810314653 0.487232331889118 no 1622 0.492155233458555 530 6742687 YHR072W ERG7
SGTC_3278 9139605 49.47 µM 0.0195179838067115 0.48728652570889 no 1623 0.49221394538623 521 7958859
SGTC_1445 4239-0156 97.7 µM 0.0187838796962386 0.487556805389326 no 1624 0.492506756847117 540 4008346
SGTC_3225 9130819 49.47 µM 0.0176976900655792 0.487956725035319 no 1625 0.492940011710401 544 4547121
SGTC_3141 9094609 49.47 µM 0.0176058202583035 0.487990550758932 no 1626 0.492976656751345 537 25236309 YDL196W YDL196W
SGTC_399 oxolinic acid 75 µM 0.0169562382127332 0.488229724090741 no 1627 0.493235763797386 525 4628 A DNA gyrase inhibitor.
SGTC_512 prima-1 270 µM 0.0158545029907473 0.488635387921492 no 1628 0.493675233394456 534 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2409 alverine citrate 63.97 µM 0.0155931226201665 0.488731631082896 no 1629 0.493779496185577 522 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_533 1222-0222 6.71 µM 0.0147440463873189 0.489044274900203 no 1630 0.494118189617429 533 3982874
SGTC_2010 4012422 159 µM 0.012556368636093 0.489849844340072 no 1631 0.494990865288463 536 952393
SGTC_422 cantharidin 155 µM 0.0113141655187702 0.490307279924573 no 1632 0.495486397305278 543 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1132 3456-3614 2.5 µM 0.010926930678184 0.490449880008309 no 1633 0.495640872102687 533 3125502
SGTC_1195 1502-0147 41.1 µM 0.0105857386688824 0.490575525730106 no 1634 0.49577698014628 544 817940
SGTC_1986 st071812 45 µM 0.010448744655918 0.490625974747632 no 1635 0.495831629827621 545 11838594
SGTC_2147 5545932 89.7195 µM 0.00926208498248879 0.491062976783292 no 1636 0.49630501552568 544 797404
SGTC_2990 9074105 71.4286 µM 0.00892167576532058 0.491188338671896 no 1637 0.496440813541588 544 6502001
SGTC_1980 st071811 45.7 µM 0.00848284029871208 0.491349949100416 no 1638 0.496615876933114 545 4974850
SGTC_3220 9131269 49.47 µM 0.00808073894049207 0.491498032665014 no 1639 0.496776286663646 544 17722206
SGTC_1354 1498-1681 81 µM 0.00784157755172573 0.491586110196286 no 1640 0.496871695229689 538 5754243
SGTC_2750 bromebric acid 70.15 µM 0.00755361169100385 0.491692161814107 no 1641 0.496986573582955 543 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1643 st009866 20.2 µM 0.00709332574817663 0.491861676419294 no 1642 0.497170196180803 547 3156273 YOR207C RET1
SGTC_3284 9108171 64.8615 µM 0.00670914060082291 0.492003165667817 no 1643 0.497323460228843 543 8687505
SGTC_1340 1486-1359 257 µM 0.00663719716578072 0.492029661397303 no 1644 0.497352160867829 539 4309068
SGTC_977 1348-1378 135 µM 0.00589699997084557 0.492302267369487 no 1645 0.49764745101894 546 X977
SGTC_949 1165-0505 146 µM 0.00585575313605002 0.492317458203397 no 1646 0.497663905841162 542 6244267
SGTC_1647 st011722 22.4 µM 0.00547679693525107 0.492457024842273 no 1647 0.497815085064226 545 2854783
SGTC_458 nppb 133 µM 0.00435237181457008 0.492871147289669 no 1648 0.498263660345097 544 4549 A chloride channel blocker.
SGTC_2586 curcumin 80 µM 0.0039583561229501 0.493016263944715 no 1649 0.498420848505515 544 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3159 9100096 49.47 µM 0.00350898670596727 0.493181768598806 no 1650 0.498600119714408 543 25236875
SGTC_2571 chrysanthemic acid 100 µM 0.00320940223027772 0.493292107480267 no 1651 0.498719635953542 545 2743 An insecticide.
SGTC_1068 loratadine 26.9 µM 0.00219686217356624 0.493665036218295 no 1652 0.499123579499714 546 3957 A H1 histamine antagonist.
SGTC_828 2074-0507 139 µM 0.00210519008790739 0.493698800252309 no 1653 0.499160151285996 546 X828
SGTC_3194 9111903 49.47 µM 0.000480511335358158 0.494297198056218 no 1654 0.49980830371949 548 17087251
SGTC_1242 0402-0103 60.1 µM -8.52301324326099e-05 0.494505573685517 no 1655 0.49996599809665 549 432868
SGTC_648 0375-0473 33.3 µM -0.00051041152022096 0.494662178785696 no 1656 0.499796375273021 549 1713139
SGTC_636 0kpi-0074 126 µM -0.00131314321127194 0.49495784747152 no 1657 0.499476131803356 549 616434
SGTC_226 1,3-diallylurea 8.28947 mM -0.00163349296950291 0.495075842090496 no 1658 0.499348330879535 549 74537 YKL182W FAS1
SGTC_746 1095-0025 46.6 µM -0.00267620444570161 0.495459907564658 no 1659 0.498932350170042 549 6749286
SGTC_804 1595-0054 20.9 µM -0.0030289112791559 0.495589822245775 no 1660 0.498791641074802 551 761523 Stimulates phospholipase C.
SGTC_59 0330-0160 1.33 µM -0.00310385654065832 0.495617427356425 no 1661 0.498761742381845 550 4293482
SGTC_797 k781-0471 270 µM -0.0031626740511088 0.4956390920348 no 1662 0.498738277705282 552 23738129
SGTC_1524 corynanthine 62.1 µM -0.00395772191352003 0.495931938991177 no 1663 0.498421101516489 555 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_657 3534-0529 86.7 µM -0.00411920302240814 0.495991419018114 no 1664 0.498356680400068 552 1049549
SGTC_1144 3486-0183 12.5 µM -0.00453246398998744 0.496143640158313 no 1665 0.498191814670994 554 6744069
SGTC_2281 7943571 200 µM -0.0045422339812396 0.496147238857848 no 1666 0.498187917048525 553 1244024
SGTC_703 3875-0075 71.8 µM -0.00496151810971331 0.496301679164708 no 1667 0.498020648771898 552 2850814
SGTC_1075 aripiprazole 15.2 µM -0.00612480932109918 0.49673017198443 no 1668 0.497556569879276 549 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2705 st078069 42.8 µM -0.00615649025578994 0.496741841562001 no 1669 0.497543931253234 553 1530061
SGTC_2597 laccaic acid a 100 µM -0.00661666281303685 0.496911345056873 no 1670 0.49736035270946 553 5491415 A textile dye.
SGTC_2746 daunorubicin 9.88 µM -0.00700861193857275 0.497055719049724 no 1671 0.497203991261086 549 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1400 3771-8998 51.5 µM -0.00709341869875126 0.497086957570068 no 1672 0.497170159099821 555 670767
SGTC_384 k007-0144 5.16 µM -0.0071352338056789 0.497102360146753 no 1673 0.497153477707868 555 6824886
SGTC_1169 aniline yellow 25.8 µM -0.00935113947714422 0.497918593659715 no 1674 0.496269489461058 552 6051 A DNA damaging agent.
SGTC_984 1492-0255 2.91 µM -0.0115058148822395 0.498712281260896 no 1675 0.495409945248023 550 1585198
SGTC_945 3381-0768 11.3 µM -0.0115286879959431 0.498720706742334 no 1676 0.495400820801068 552 1126236 YIL048W NEO1
SGTC_1759 st043059 70 µM -0.012259411240304 0.49898987436043 no 1677 0.495109325029557 555 669426
SGTC_1284 0929-0043 16 µM -0.0147911583555898 0.499922465975422 no 1678 0.494099396710684 554 1239883
SGTC_2263 7948595 193.29 µM -0.0152121278647755 0.499922465975422 no 1679 0.493931473072561 573 2971371
SGTC_2144 5628481 200 µM -0.0155276117818122 0.499806254535413 no 1680 0.493805628065034 551 2818399
SGTC_1170 0310-0127 64.8 µM -0.0168581262163901 0.499316147445081 no 1681 0.49327489922704 562 774975
SGTC_805 3852-0218 479 µM -0.0170951297200199 0.499228845136483 no 1682 0.493180362133116 555 6615355
SGTC_1645 Cervolide 78 µM -0.0206270199698293 0.49792784921594 no 1683 0.491771593114955 558 23173 A fragrance.
SGTC_332 4112-0506 40.9 µM -0.0219533889719177 0.497439277073852 no 1684 0.491242568389226 559 2790355
SGTC_1654 st012436 41.8 µM -0.022293812783087 0.497313881495623 no 1685 0.491106792170505 563 4323132
SGTC_2870 9038528 12.99 µM -0.0230421000224571 0.49703824981384 no 1686 0.490808345446019 586 6463316
SGTC_2336 9001819 198.65 µM -0.0231970155370457 0.496981186840372 no 1687 0.490746559612323 552 2989602
SGTC_1123 mangostin 811.285 nM -0.023334185423888 0.496930660502496 no 1688 0.490691851553323 562 5281650 An antioxidant.
SGTC_1506 4226-2149 212 µM -0.0237784098718574 0.496767031384278 no 1689 0.490514680803266 579 991114
SGTC_1121 fusaric acid 630.51 nM -0.025150404950232 0.496261663508499 no 1690 0.489967497771907 567 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3172 9105863 49.47 µM -0.0258441471780127 0.496006129084116 no 1691 0.489690824619852 559 2348785
SGTC_2791 5663188 71.43 µM -0.0269875737507362 0.49558496063843 no 1692 0.489234822566637 562 54690634
SGTC_357 1325-0123 420 µM -0.0291425132947605 0.494791226406027 no 1693 0.488375464738844 566 1098503
SGTC_1107 amlodipine 47 µM -0.0313117071877592 0.493992262666643 no 1694 0.487510477000542 565 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_957 1187-1561 14.1 µM -0.0313181476963156 0.493989890514287 no 1695 0.487507908868867 556 1538454
SGTC_1480 1070-0044 41.2 µM -0.0319637340557175 0.493752110818115 no 1696 0.487250486070483 561 3124987
SGTC_1717 st033143 58.0435 µM -0.0325154190392789 0.493548918243878 no 1697 0.487030509958095 561 674616
SGTC_555 4296-0685 37 µM -0.0329256373202162 0.493397830731958 no 1698 0.486866944125708 570 2908540 YHR072W ERG7
SGTC_2372 9071633 200 µM -0.0334177721810585 0.493216573772715 no 1699 0.486670718713235 558 21321366
SGTC_2162 5663267 200 µM -0.0334846092767958 0.493191957276405 no 1700 0.486644069484029 584 6456493
SGTC_2957 9076800 11.52 µM -0.0338079577299352 0.493072866503043 no 1701 0.48651514511185 570 16459615
SGTC_3038 9091290 49.47 µM -0.0339701523048103 0.493013129701465 no 1702 0.486450475984229 567 25236843
SGTC_1727 st034309 9.9045 µM -0.034222661795227 0.492920129928346 no 1703 0.486349797812037 611 870305
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0346365918671132 0.492767679452452 no 1704 0.486184761452388 566 165506
SGTC_1024 4507-0395 26 µM -0.03589193903004 0.492305341552087 no 1705 0.485684261724955 558 4201836
SGTC_2600 tangeritin 87.95 µM -0.0360025658772327 0.492264598740078 no 1706 0.485640156503986 574 68077 A bioactive flavone.
SGTC_1889 st059080 5.18 µM -0.0363051059104331 0.492153176546646 no 1707 0.485519539348785 589 176925 Isolated from Daphnopsis sellowiana.
SGTC_602 3130-1533 38.1 µM -0.0367753590552608 0.491979988662606 no 1708 0.485332060690018 563 720941
SGTC_2975 9084847 53.72 µM -0.0368313808599691 0.491959356688462 no 1709 0.485309726354417 560 27211724
SGTC_210 3551-0445 56.827 µM -0.0376848952988239 0.491645023063045 no 1710 0.484969459623966 563 2865180 YOR207C RET1
SGTC_1452 4194-0072 190 µM -0.0382016180645706 0.491454726107821 no 1711 0.484763465405121 595 1343545
SGTC_2628 lathosterol 100 µM -0.0389673551320519 0.491172726576624 no 1712 0.484458207833306 571 6710616
SGTC_1860 st056228 74.6 µM -0.039400703823202 0.491013138327765 no 1713 0.484285459388477 561 688679
SGTC_1215 3852-0577 11.2 µM -0.0410078525552304 0.490421290408166 no 1714 0.483644817847914 572 2884876
SGTC_145 3737-0113 38.366 µM -0.0415968457460681 0.490204393233927 no 1715 0.483410043898602 568 6849351
SGTC_2107 5363541 170.161 µM -0.0420881781606266 0.490023461925413 no 1716 0.483214202141196 561 244052
SGTC_3312 9133330 71.43 µM -0.0421329401432384 0.490006978595614 no 1717 0.48319636052006 590 17617324
SGTC_2165 5727197 32.143 µM -0.0429986550781764 0.48968818768928 no 1718 0.482851302977899 577 1361712
SGTC_1065 prochlorperazine maleate 2.48 µM -0.0430457116590009 0.489670859758777 no 1719 0.482832547483623 567 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3310 9130229 44.1445 µM -0.0439902624328843 0.489323046258697 no 1720 0.482456082903916 597 7761258
SGTC_3256 9138902 49.47 µM -0.0440816207913879 0.489289405645038 no 1721 0.482419671513006 565 17228773
SGTC_3260 9137109 49.47 µM -0.0475310690429005 0.488019283582555 no 1722 0.481044984397871 564 17478346
SGTC_2232 chlorophetanol 41.5365 µM -0.0477383382830083 0.487942968673479 no 1723 0.480962389694265 579 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2035 5154463 94.595 µM -0.048405826990364 0.487697207579125 no 1724 0.480696407741955 571 2769623
SGTC_2370 9071495 200 µM -0.0488498801104805 0.487533715289126 no 1725 0.480519465507604 590 21791103
SGTC_775 4577-0580 57.3 µM -0.0490510436849394 0.487459651204193 no 1726 0.480439308943645 606 2006902
SGTC_3181 9108277 49.47 µM -0.0510644760090268 0.486718373143597 no 1727 0.479637071541037 573 17097298
SGTC_2505 galangin 7.89 µM -0.0524156161968137 0.486220954342756 no 1728 0.479098765647858 590 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2098 5376439 882.5 nM -0.053399955158442 0.485858585927867 no 1729 0.478706620470913 583 2844116
SGTC_3273 9137859 49.47 µM -0.0536864304896429 0.48575312686401 no 1730 0.478592497055396 565 2377234
SGTC_1786 berberine 21.6 µM -0.0539006561643048 0.485674265439578 no 1731 0.478507156942035 595 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_616 4092-0450 108 µM -0.0541682532712469 0.485575757544196 no 1732 0.478400556877221 580 787165
SGTC_2716 st080858 38.6235 µM -0.0549115826524349 0.485302127635158 no 1733 0.478104452090314 562 5296050
SGTC_1928 4'-methoxychalcone 40.3 µM -0.055055441634896 0.485249171933263 no 1734 0.478047147346811 563 641818
SGTC_1805 st050013 60.3 µM -0.0554581351968786 0.485100938431052 no 1735 0.477886740932465 569 4037144
SGTC_104 0074-0074 590.992 µM -0.0561945627612761 0.484829861123344 no 1736 0.477593406304124 594 3943124
SGTC_2789 5281112 71.43 µM -0.0567747404980028 0.48461630395209 no 1737 0.477362317817973 574 765948
SGTC_1930 st074634 34.3 µM -0.0586830954062285 0.483913890536856 no 1738 0.476602262021585 593 684253 YOR116C RPO31
SGTC_2696 st077691 74.316 µM -0.0602742693204334 0.483328260868563 no 1739 0.475968597392378 581 757133
SGTC_1856 st057054 55.7 µM -0.0607669851480748 0.483146924627592 no 1740 0.475772391873242 580 1266018
SGTC_2989 9073649 71.4286 µM -0.0610584528514569 0.4830396562036 no 1741 0.475656328601474 571 21367202
SGTC_1029 k015-0030 64.7 µM -0.0619611503692458 0.482707445606227 no 1742 0.475296885020392 578 2208316
SGTC_3009 9080819 71.4286 µM -0.06301904305776 0.482318135403011 no 1743 0.474875670146444 584 17027216
SGTC_1503 4585-0012 61.3 µM -0.0654744167833246 0.481414610263489 no 1744 0.473898137533927 597 2922052
SGTC_1246 0422-0085 105 µM -0.0654841461068043 0.481411030266862 no 1745 0.473894264407423 585 264295
SGTC_911 3456-4043 236 µM -0.0663295239498618 0.48109997124672 no 1746 0.473557739131429 574 914281
SGTC_693 4161-2696 114 µM -0.0669086149587394 0.480886899803167 no 1747 0.473327227332218 575 805759
SGTC_2514 salinomycin 42.74 µM -0.0669266604984509 0.480880260192954 no 1748 0.473320044304166 596 23682228 A polyether potassium ionophore.
SGTC_420 mitomycin C 81.9 mM -0.0677575474482965 0.480574552446759 no 1749 0.472989319142498 572 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2603 homopterocarpin 100 µM -0.0679079925775832 0.48051920047525 no 1750 0.47292943814296 584 101795 A weak amylase inhibitor.
SGTC_1834 st055981 52.8 µM -0.0687752510258166 0.480200124953283 no 1751 0.472584259125316 577 471719 YDL150W RPC53
SGTC_230 MPP+ 141.667 µM -0.0691574118889692 0.480059527078003 no 1752 0.472432161146448 597 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_100 0086-0128 49.5915 µM -0.0693098836328905 0.480003433058193 no 1753 0.472371479328723 607 93297
SGTC_1797 st048695 56.8 µM -0.0727959649091962 0.47872102164717 no 1754 0.47098424098764 572 592262 YIL048W NEO1
SGTC_2992 9074591 71.4286 µM -0.0737272339900326 0.478378475977075 no 1755 0.470613714083134 571 17741321
SGTC_3140 9094243 49.47 µM -0.0741763101902413 0.478213299434458 no 1756 0.470435047820609 582 19291112
SGTC_1175 0741-0056 27.6 µM -0.0767769596982683 0.477256818442792 no 1757 0.469400490061012 589 765927
SGTC_2443 5493264 126.67 µM -0.0778218609120048 0.476872555584524 no 1758 0.468984878344852 607 5340055
SGTC_2439 5492030 7.2 µM -0.0779436525020568 0.476827768068814 no 1759 0.468936437667109 586 5722370
SGTC_2004 4023728 41.89 µM -0.0782248031046508 0.476724379150293 no 1760 0.468824616220969 577 360084 YDR527W RBA50
SGTC_3306 9127676 59.7925 µM -0.0782523841750848 0.476714236709471 no 1761 0.46881364659134 583 41905287
SGTC_1285 0929-0069 65.5 µM -0.0793079830965842 0.476326070657298 no 1762 0.468393828355867 582 1206237
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0797827751704802 0.476151486870812 no 1763 0.468205012035457 585 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_37 0566-0070 1.56 µM -0.0803607811335623 0.47593895692364 no 1764 0.467975159053995 600 1626686
SGTC_1241 0364-0022 50.8 µM -0.0815004746012886 0.475519917358041 no 1765 0.467521973729332 600 4563895
SGTC_705 1124-0212 310 µM -0.0822368001694112 0.475249201433098 no 1766 0.467229205117482 577 9554485
SGTC_1055 3448-0672 86 µM -0.0844714944881012 0.474427668851112 no 1767 0.466340782961631 599 748378
SGTC_5 0352-0601 109.883 µM -0.0847441979828504 0.474327423226407 no 1768 0.466232378708363 596 762456
SGTC_2105 5350118 200 µM -0.0849014530582662 0.474269617102969 no 1769 0.466169868293475 591 2133313
SGTC_1557 sumaresinolic acid 42.3 µM -0.085763202710737 0.473952852196772 no 1770 0.465827329322499 585 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2532 xanthone 78.9 µM -0.0859540754427733 0.47388269276099 no 1771 0.465751462270407 601 7020 An insecticide.
SGTC_1881 5652484 16 µM -0.0860520680019447 0.47384667377311 no 1772 0.465712513206018 628 2255129
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0864802413058591 0.473689293222755 no 1773 0.465542331187095 583 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3071 9117417 49.47 µM -0.0872209408145969 0.473417049396338 no 1774 0.465247947211897 599 45595590 YGL055W OLE1
SGTC_260 nsc-65238 3.989 µM -0.0889117903636834 0.472795625002408 no 1775 0.464576006655009 587 3246252
SGTC_2768 sulfasalazine 50.2 µM -0.0892799735666793 0.472660318303998 no 1776 0.464429704641382 606 5384001 An antioxidant and salicylic acid derivative.
SGTC_897 1000-0139 31.4 µM -0.0896908385441671 0.472509329851563 no 1777 0.464266448191033 610 6151020
SGTC_2863 9028737 58.44 µM -0.0897107353212754 0.472502018100455 no 1778 0.464258542395396 630 6460917
SGTC_937 3122-0005 46.7 µM -0.0941476720978084 0.470871749928834 no 1779 0.462495925834497 583 759535
SGTC_1394 3474-0001 65.7 µM -0.0941529645245448 0.47086980561311 no 1780 0.462493823798901 593 5017666 YIL048W NEO1
SGTC_1760 st045453 10.4495 µM -0.0942822832037361 0.470822297123842 no 1781 0.462442461586998 591 3323419 YIL048W NEO1
SGTC_704 1310-0270 142 µM -0.0945974937453637 0.470706498295866 no 1782 0.462317270305694 598 5718033
SGTC_1135 dihydrocapsaicin 536.708 nM -0.0947280843202341 0.470658523989944 no 1783 0.462265405108517 625 107982 A Capsaicinoid.
SGTC_361 000s-0510 1.45 µM -0.0947437557806525 0.470652766884566 no 1784 0.462259181093063 601 660
SGTC_2720 fluspirilene 36.88 µM -0.0955693069214278 0.470349499134024 no 1785 0.461931321558414 601 3396 An atypical antipsychotic.
SGTC_1642 st009582 77.7 µM -0.0967871578893723 0.469902150757152 no 1786 0.461447711284992 608 6739311
SGTC_3205 9113483 49.47 µM -0.0978500388688507 0.469511757916275 no 1787 0.461025686362292 629 17018033
SGTC_1658 st012944 20 µM -0.098288170210522 0.469350842161487 no 1788 0.460851735750875 614 24207260
SGTC_1317 1273-0028 910 nM -0.0990568492809102 0.469068535797029 no 1789 0.46054656640374 609 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2930 9013230 14.89 µM -0.0997203228317382 0.468824879886509 no 1790 0.460283182838419 601 2995857
SGTC_792 4534-1957 155 µM -0.0998451665976386 0.468779033209937 no 1791 0.460233624712045 583 1717904
SGTC_1830 st055982 50.3 µM -0.101186252396393 0.468286569279727 no 1792 0.459701304851073 622 455313 An antimicrobial agent.
SGTC_558 k064-0027 21.3 µM -0.101454224405034 0.468188172309083 no 1793 0.459594946815334 600 5088526
SGTC_1342 1486-1464 234 µM -0.102387551925467 0.467845477842433 no 1794 0.459224531934677 599 3253938
SGTC_65 0798-0905 34.986 µM -0.10256429939707 0.467780583277767 no 1795 0.459154389159683 663 3602145
SGTC_1207 2099-0101 141 µM -0.103300027934121 0.46751046256193 no 1796 0.458862426725339 592 5837381
SGTC_206 4546-0025 72.014 µM -0.103798835569524 0.467327335207842 no 1797 0.458664495279944 625 6620745 YIL048W NEO1
SGTC_237 nikkomycin 200 µM -0.104943134397322 0.466907254725035 no 1798 0.458210465807815 610 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_427 1354-0053 47.3 µM -0.104995395927431 0.466888070011052 no 1799 0.458189731022668 636 6813657
SGTC_2983 9022671 12.99 µM -0.105066916928553 0.466861815451886 no 1800 0.458161355218298 621 6405161
SGTC_2469 5655019 90.81 µM -0.10861418411094 0.46555983659145 no 1801 0.456754255011019 590 2788239
SGTC_1745 st081495 74 µM -0.109489672981124 0.465238555815167 no 1802 0.456407056146357 592 13842402 YBL026W LSM2
SGTC_2461 5755302 26.15 µM -0.109924247991101 0.46507908692232 no 1803 0.456234725978834 632 2788904
SGTC_232 clozapine 119 µM -0.110163563621066 0.464991271567629 no 1804 0.45613982918295 601 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1093 fluphenazine 7.97 µM -0.110202891627667 0.464976840567699 no 1805 0.456124234528436 619 6602611 An atypical antipsychotic.
SGTC_400 oxethazaine 37.5 µM -0.111740953968371 0.464412501024121 no 1806 0.455514403041257 620 4621 A local anesthetic.
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.112288509521341 0.464211611399743 no 1807 0.455297326128469 628 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1558 st069300 45.6 µM -0.112423096128687 0.464162235059605 no 1808 0.455243971674215 599 24208000
SGTC_476 mead acid 10 µM -0.112473892059076 0.464143599491904 no 1809 0.455223834745564 599 5312531 An omega 9 fatty acid.
SGTC_2706 st078239 82.5 µM -0.113808128800025 0.463654134650973 no 1810 0.454694947307273 580 15434492
SGTC_2399 5884133 200 µM -0.114018215594957 0.463577069289627 no 1811 0.454611676826483 613 722445
SGTC_1330 1469-0054 61.8 µM -0.114202596079624 0.463509434804945 no 1812 0.45453859700074 599 7102664
SGTC_837 0091-0265 12.5 µM -0.114714381009701 0.463321707291559 no 1813 0.45433575739209 605 759367
SGTC_534 k292-0788 63.4 µM -0.115111325253737 0.463176110040904 no 1814 0.454178441661943 630 4146317
SGTC_2854 9024559 71.43 µM -0.115617050322279 0.462990619651978 no 1815 0.453978024663699 622 3163529
SGTC_1806 st050005 60.3 µM -0.117459538076525 0.462314898355543 no 1816 0.453247952985942 600 5194765
SGTC_74 000s-0487 160.283 µM -0.117790553600612 0.46219351187112 no 1817 0.45311680728692 602 677548
SGTC_2427 5545055 42.75 µM -0.118956268603346 0.461766061401232 no 1818 0.452655001146872 626 5372858
SGTC_1306 1185-0270 9.02 µM -0.11931706767499 0.461633770638013 no 1819 0.452512081022449 614 1548076
SGTC_2732 terfenadine 20 µM -0.119912013856026 0.461415636659402 no 1820 0.452276423733889 592 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2999 9069765 71.4286 µM -0.120155668109234 0.461326305418445 no 1821 0.452179917497869 600 2097066
SGTC_1324 1418-0026 34.4 µM -0.121467121323411 0.460845519436872 no 1822 0.451660527612799 634 1372513
SGTC_2819 7996655 46.38 µM -0.121639997739181 0.460782146243436 no 1823 0.451592067532149 609 6456960
SGTC_2294 7971431 200 µM -0.122420262071259 0.460496128652404 no 1824 0.451283096194228 633 5741572
SGTC_2913 7966556 36.57 µM -0.123379801925641 0.460144422966086 no 1825 0.450903175294941 611 2976516
SGTC_3092 9117248 49.47 µM -0.123955278048386 0.459933505318619 no 1826 0.450675342418822 590 17141857
SGTC_1270 0831-1170 17.3 µM -0.12496170898697 0.459564665636844 no 1827 0.450276932232186 598 6764716
SGTC_1495 4469-0029 237 µM -0.125880533972791 0.459227962413233 no 1828 0.449913245864956 617 793680
SGTC_495 decylubiquinone 155 µM -0.126371170680301 0.459048180656353 no 1829 0.449719060820412 645 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2387 9077560 195.08 µM -0.126422654103956 0.459029316306593 no 1830 0.449698685319121 595 5303272
SGTC_2019 4016004 108 µM -0.1286238195572 0.458222860925914 no 1831 0.448827658793343 615 45595336
SGTC_1613 st002381 52.1 µM -0.129189530713101 0.458015625271676 no 1832 0.448603840034751 592 551167
SGTC_1793 st048256 72.231 µM -0.130012312437011 0.457714237938647 no 1833 0.44827834272876 602 672022
SGTC_2953 9074162 66.49 µM -0.130524608519752 0.457526594668383 no 1834 0.44807569294933 594 16451992
SGTC_3012 9080433 71.4286 µM -0.13120443744432 0.457277602269907 no 1835 0.447806792866534 601 17688859
SGTC_871 0574-0004 149 µM -0.131416818750454 0.457199819470499 no 1836 0.447722792303856 601 9551173
SGTC_444 curcumin 90.4 µM -0.132750053897029 0.456711571307138 no 1837 0.447195527927533 616 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_286 k060-0067 22.9 µM -0.133058761444416 0.456598527852072 no 1838 0.447073454338431 611 5985051
SGTC_1471 k673-0312 37 µM -0.133396883334971 0.456474717395309 no 1839 0.446939755059727 607 24099884
SGTC_2525 harmine 47.85 µM -0.133661116706113 0.456377965717994 no 1840 0.446835276784077 598 5280953 A monoamine oxidase inhibitor
SGTC_829 1635-0120 117 µM -0.134525174201424 0.45606160055702 no 1841 0.446493652939363 598 285054
SGTC_2385 9074692 200 µM -0.135639796641212 0.455653534963455 no 1842 0.446053021501345 596 17046906
SGTC_3054 9094397 49.47 µM -0.136244827205932 0.455432051575284 no 1843 0.445813869276625 634 2598354
SGTC_2258 7960471 200 µM -0.137256843226627 0.455061614117492 no 1844 0.445413890810928 646 2974708
SGTC_1348 1493-0373 93.8 µM -0.137510027648231 0.454968944811376 no 1845 0.445313833560912 632 3010129
SGTC_1686 st019653 115.5 µM -0.13781648827106 0.454856778893056 no 1846 0.445192726476405 620 97252
SGTC_950 1165-0508 94.1 µM -0.139471430391437 0.454251125314978 no 1847 0.444538815254606 620 6148369
SGTC_3121 9125696 49.47 µM -0.139661929313437 0.454181415867299 no 1848 0.444463553765433 607 1235365
SGTC_2804 7954240 19.48 µM -0.13987737000064 0.454102581157009 no 1849 0.444378440804559 620 828705
SGTC_2032 5185112 25.99 µM -0.139966937898521 0.454069806731865 no 1850 0.444343056465064 595 5718189
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.141339124953478 0.453567739258355 no 1851 0.443801021295032 620 4174840
SGTC_717 1532-0246 73.2 µM -0.141770454039422 0.453409936192823 no 1852 0.443630661282398 615 9561992
SGTC_2458 5808907 16.39 µM -0.142643718700496 0.453090472193911 no 1853 0.443285783989642 600 2731747
SGTC_1059 3448-6867 171 µM -0.142862838440838 0.453010316980812 no 1854 0.443199254043213 603 3934407
SGTC_1399 3562-5772 25 µM -0.143408853013109 0.452810590166443 no 1855 0.442983645775882 604 23847490
SGTC_1217 1183-1422 255 µM -0.144194634962554 0.452523179745596 no 1856 0.442673388676455 611 2849664
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.144219814241066 0.452513970492987 no 1857 0.442663447503871 626 6708760
SGTC_55 0767-0285 6.563 µM -0.145309980508507 0.45211526970933 no 1858 0.442233067528093 614 3116166
SGTC_3074 9116018 49.47 µM -0.145396600324254 0.452083592764446 no 1859 0.442198874345473 605 17027303
SGTC_2858 9025781 8.96 µM -0.145790001184985 0.451939729555787 no 1860 0.442043584731652 637 4894980 YPL153C RAD53
SGTC_2321 7390090 138.78 µM -0.146419731941611 0.451709455741939 no 1861 0.441795025669436 626 649046
SGTC_465 cgp-37157 41 µM -0.146665314277016 0.45161965798293 no 1862 0.441698098838052 621 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1825 st052143 62.6 µM -0.14710089756585 0.451460392019942 no 1863 0.441526190715579 636 674173
SGTC_405 ebelactone b 50 µM -0.147865697441064 0.451180770758727 no 1864 0.441224380021507 610 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2183 6420625 130.508 µM -0.149195418450625 0.450694664379428 no 1865 0.440699717540047 608 2897619
SGTC_2927 9011802 47.9 µM -0.15043509282211 0.450241542957455 no 1866 0.440210678110493 622 43912568
SGTC_2185 6113692 200 µM -0.150745128837899 0.450128229797243 no 1867 0.44008838615755 621 874150
SGTC_131 0141-0277 33.849 µM -0.151597447563074 0.449816742037329 no 1868 0.439752223344421 637 1547771
SGTC_3299 9121982 43.1275 µM -0.152658654802503 0.449428957269692 no 1869 0.439333733596199 630 17594604 YPL160W CDC60
SGTC_323 4013-0906 34.3 µM -0.154327740079276 0.448819140468051 no 1870 0.438675662950721 612 2910086
SGTC_1176 0848-0131 83.3 µM -0.15642531973767 0.448052940608888 no 1871 0.437848890282239 621 6769040
SGTC_1778 st046819 58.9 µM -0.156718875006396 0.447945726696229 no 1872 0.437733205397583 594 671715
SGTC_3149 9097855 49.47 µM -0.156754550943744 0.447932697187956 no 1873 0.437719146510818 603 25236625 YMR079W SEC14
SGTC_623 k072-0108 16.9 µM -0.156976748238901 0.447851547915405 no 1874 0.437631586556327 636 5382803
SGTC_1145 3546-0597 10.2 µM -0.157235563340817 0.447757028106904 no 1875 0.437529600693238 616 875334
SGTC_1906 st060206 94.7 µM -0.157349550575423 0.447715400674575 no 1876 0.437484685439811 611 5133468
SGTC_2661 dactinomycin 12.96 µM -0.157501504090521 0.447659909087246 no 1877 0.437424811298164 607 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.158951769492225 0.447130341388404 no 1878 0.43685343648973 605 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2216 7189485 200 µM -0.160220265823326 0.446667224314002 no 1879 0.436353782899053 623 731273
SGTC_1587 estradiol valerate 56.1 µM -0.160240666762352 0.4466597766996 no 1880 0.436345747911131 626 13791 A steroid.
SGTC_292 k038-0015 474 µM -0.160627865976189 0.446518428421174 no 1881 0.436193253002599 629 46368540
SGTC_891 0929-0073 133 µM -0.161276504366653 0.446281656191905 no 1882 0.435937813901691 656 5603632
SGTC_1116 jasmonic acid 1.58368 µM -0.161558241036774 0.446178819921487 no 1883 0.435826872015071 642 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1085 doxorubicin 7.67 µM -0.161720997867569 0.446119413949214 no 1884 0.435762784149987 618 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2967 9089538 49.85 µM -0.162048301547295 0.445999952313946 no 1885 0.435633908682902 624 728216
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.165165942249978 0.44486230077451 no 1886 0.434406685603248 649 6728940
SGTC_1705 st027868 56.3335 µM -0.165971457118814 0.444568435512456 no 1887 0.434089706261131 632 292948
SGTC_1064 honokiol 6.76 µM -0.166026915952628 0.444548204323851 no 1888 0.434067884130659 635 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2980 9014342 25.29 µM -0.169059337803761 0.443442208763556 no 1889 0.43287498410862 624 2996599
SGTC_941 3237-0776 460 µM -0.169563231697704 0.443258469254094 no 1890 0.432676820297217 614 760008
SGTC_2355 9061122 103.12 µM -0.169917087720294 0.44312944673627 no 1891 0.432537671239621 645 5302957
SGTC_3346 9158254 43.5805 µM -0.169947681751296 0.443118291863908 no 1892 0.432525640946642 611 17639500
SGTC_2026 5148700 152 µM -0.170429744328417 0.442942533257189 no 1893 0.432336090861329 613 79838
SGTC_1393 3470-5649 58.2 µM -0.171450334225078 0.442570466250786 no 1894 0.431934839829764 629 4108395
SGTC_2318 6029776 164 µM -0.172928145452132 0.442031804144913 no 1895 0.431353954028061 650 818325
SGTC_1679 SEC14.276 6.7 µM -0.173802921738576 0.441712998671378 no 1896 0.431010174064199 625 1005053 YMR079W SEC14
SGTC_752 1896-0090 130 µM -0.175347106019717 0.441150324887987 no 1897 0.430403449920505 624 772567
SGTC_3208 9114115 49.47 µM -0.175864893776988 0.440961678605379 no 1898 0.430200043073529 652 650895
SGTC_2195 6536160 144.242 µM -0.177923587380473 0.440211765028955 no 1899 0.429391493172919 618 3834386
SGTC_185 k048-0037 25.491 µM -0.178112048345053 0.440143125642906 no 1900 0.42931749005735 610 6827589
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.178148727114789 0.440129767073703 no 1901 0.429303087664605 637 5377381
SGTC_827 3253-0474 693 µM -0.179242949416195 0.439731277910207 no 1902 0.428873470507374 647 5402065
SGTC_647 0140-0236 81 µM -0.180391914424827 0.439312918499687 no 1903 0.428422450778722 636 990837
SGTC_3090 9117696 49.47 µM -0.180632069961142 0.4392254819751 no 1904 0.428328190869709 658 7923821
SGTC_1974 st069448 26.9 µM -0.180686829435417 0.439205545401773 no 1905 0.428306698608036 610 6323587 YNR016C ACC1
SGTC_1483 3453-0561 55.9 µM -0.181033377271484 0.439079379464272 no 1906 0.428170688781429 632 4546991
SGTC_2504 purpurogallin 52.29 µM -0.181198775713587 0.439019165861649 no 1907 0.42810577776768 622 5281571 An antioxidant.
SGTC_1602 st001878 87.6 µM -0.18127944871597 0.438989797220824 no 1908 0.428074118160878 672 595405 YLR310C CDC25
SGTC_1392 3455-1037 33.9 µM -0.18138290315608 0.438952135592414 no 1909 0.42803351880131 621 981132
SGTC_1665 st014639 11.4 µM -0.182383009326824 0.438588084772497 no 1910 0.427641079387455 617 981133 YIL048W NEO1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.184039880614837 0.437985077931816 no 1911 0.426991084513813 606 66535 A nucleotide analog.
SGTC_590 k048-0076 22.4 µM -0.186479148596029 0.437097585618227 no 1912 0.426034514533524 644 6832814
SGTC_258 haloperidol 50.781 µM -0.188072417227352 0.436518068479166 no 1913 0.42540994155408 621 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1799 st045822 46.1415 µM -0.188141707952283 0.436492868552914 no 1914 0.425382783317025 624 3674992
SGTC_410 α-linolenic acid 100 µM -0.188240881576418 0.436456801143582 no 1915 0.425343913206905 641 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_896 0964-0007 44.5 µM -0.189256233034229 0.436087569125617 no 1916 0.424945998168234 621 6756758
SGTC_86 0417-1630 471.922 µM -0.191651653395707 0.435216697031224 no 1917 0.424007539424883 622 3634867
SGTC_2211 7117706 200 µM -0.191954121614195 0.435106754811144 no 1918 0.42388907135185 613 822771
SGTC_1211 1056-0033 32.3 µM -0.192283479287522 0.434987044422449 no 1919 0.423760079278069 629 6741922
SGTC_496 calpeptin 138 µM -0.19229411868862 0.434983177458844 no 1920 0.423755912520507 628 73364 A calpain inhibitor.
SGTC_2569 tetrandrine 100 µM -0.192756484972816 0.434815133260841 no 1921 0.423574842128425 636 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2352 9027995 87.8 µM -0.193920809026061 0.434392019029242 no 1922 0.42311894486619 640 2997347
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.196079655366042 0.433607695545904 no 1923 0.422273909913321 626 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2433 5607874 27.82 µM -0.196882162311023 0.433316205815323 no 1924 0.42195987644213 622 2252428
SGTC_1898 st060199 18.6 µM -0.197569913487857 0.43306642698209 no 1925 0.421690788162244 619 688866
SGTC_2057 5236571 38.335 µM -0.197824194976774 0.432974083292782 no 1926 0.421591307698654 638 54684039 YBR257W POP4
SGTC_1915 st067105 30.6 µM -0.198008294880393 0.432907228707161 no 1927 0.421519286924296 655 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3133 9127736 49.47 µM -0.198824110765026 0.432610994039677 no 1928 0.42120016742349 652 27243420
SGTC_2287 7945887 168.79 µM -0.200210823702904 0.432107545297449 no 1929 0.420657851230799 645 1245853
SGTC_540 1187-0821 17.3 µM -0.201623612045997 0.431594743188858 no 1930 0.420105492283573 654 847520
SGTC_2383 9036125 200 µM -0.202001455972495 0.431457616056695 no 1931 0.419957792971912 644 79580
SGTC_1900 st060200 72.8 µM -0.202629192661021 0.431229816102821 no 1932 0.419712435430708 621 688945
SGTC_2682 pyrogallin 40.03 µM -0.202756003859867 0.431183800242979 no 1933 0.419662873714823 652 822798 An ATP competetive kinase inhibitor.
SGTC_481 bay k-8644 50 µM -0.203303072306105 0.430985296747452 no 1934 0.419449077160309 685 2303 A calcium channel antagonist.
SGTC_1231 0242-0792 125 µM -0.203584948446488 0.430883024941492 no 1935 0.419338928106092 661 3707635
SGTC_101 0490-5701 117.494 µM -0.203699167007598 0.430841584872584 no 1936 0.419294296590457 628 4661669
SGTC_2214 7179297 48.276 µM -0.204075322543262 0.430705115843046 no 1937 0.419147319140495 628 769744
SGTC_426 0988-0037 14.6 µM -0.206282837614946 0.42990439783388 no 1938 0.418284991919986 666 5383008
SGTC_330 1488-0319 80.1 µM -0.206367333144705 0.429873755009959 no 1939 0.418251992991963 629 6846614
SGTC_2796 7949634 45.45 µM -0.207064683586429 0.429620872726418 no 1940 0.417979671380316 634 2971588
SGTC_1026 k007-1105 30.6 µM -0.207588036434879 0.429431106673145 no 1941 0.417775323212286 605 7066794
SGTC_2083 5306046 65.942 µM -0.207767236595702 0.429366133018693 no 1942 0.417705357880221 647 539837
SGTC_3314 9135860 59.4275 µM -0.208125063598324 0.429236399308266 no 1943 0.417565658853723 625 25252478
SGTC_869 0564-0080 44.1 µM -0.208808023586437 0.428988806652884 no 1944 0.417299053744055 632 6843321
SGTC_3099 9120367 49.47 µM -0.209349345185099 0.428792581834166 no 1945 0.417087766604051 646 24824940
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.209529616058076 0.428727238965634 no 1946 0.417017409090021 628 688664
SGTC_1871 st057448 67.3 µM -0.209847428571935 0.428612046072501 no 1947 0.416893377231715 657 691747
SGTC_1183 1254-0324 198 µM -0.21021202382356 0.428479904009421 no 1948 0.416751097785167 638 5799357
SGTC_761 k216-0224 480 µM -0.211271496530371 0.42809595962271 no 1949 0.416337711697063 710 1340404
SGTC_1385 3091-4834 14.1 µM -0.21154101521292 0.427998299065233 no 1950 0.416232565380383 637 4072814
SGTC_2155 5570423 76 µM -0.21168112202198 0.427947532864236 no 1951 0.416177908402072 671 797402
SGTC_1756 st041558 35.5 µM -0.212716071717492 0.427572566929601 no 1952 0.415774215113446 682 3955792
SGTC_1397 3532-0190 20.1 µM -0.213639596848724 0.427238025723264 no 1953 0.415414059192776 634 5322280
SGTC_2358 9037157 4 µM -0.215026262826821 0.426735812965943 no 1954 0.414873421337486 630 2388925
SGTC_2760 etidronate 98.04 µM -0.216182282655445 0.426317224707212 no 1955 0.414422831707311 630 3305 A chelator and antioxidant.
SGTC_1470 k295-0292 231 µM -0.21710942890716 0.425981570227102 no 1956 0.414061533006885 633 5045612
SGTC_785 1270-0111 65.3 µM -0.21772847929522 0.425757485437901 no 1957 0.413820336345635 632 6741994
SGTC_2159 5658611 73.75 µM -0.218019764040823 0.425652054038335 no 1958 0.413706856165994 667 793844
SGTC_1122 capsaicin 818.572 nM -0.218839121469495 0.425355513653658 no 1959 0.4133876854438 669 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_788 1182-0090 188 µM -0.219104148143945 0.425259604699772 no 1960 0.413284459764264 633 5715185
SGTC_632 0781-2353 4.65 µM -0.21912015447588 0.425253812403453 no 1961 0.413278225623324 651 6811515 YHR007C ERG11
SGTC_1568 digitonin 820 nM -0.219285040500054 0.42519414516184 no 1962 0.413214007141447 673 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2909 7941780 10.49 µM -0.219400686959578 0.42515229724463 no 1963 0.413168967474247 662 1243215
SGTC_1932 st074806 40.9 µM -0.219822430860389 0.424999691819971 no 1964 0.41300472479246 635 17251235
SGTC_2342 7990637 118.86 µM -0.219882681889217 0.424977891274389 no 1965 0.412981262054557 689 2033102 YER133W GLC7
SGTC_2175 5807670 165.306 µM -0.220031485986225 0.424924050679044 no 1966 0.412923316632865 632 241186
SGTC_3184 9108758 49.47 µM -0.222529164836972 0.424020545330477 no 1967 0.411950986054098 636 902885
SGTC_1142 3253-1408 9.78 µM -0.222988622840734 0.423854385244139 no 1968 0.411772180622892 648 256655
SGTC_1156 4092-0367 4.88 µM -0.223478823083068 0.423677122347674 no 1969 0.411581431556604 632 1357585
SGTC_610 4215-0184 155 µM -0.224669766305469 0.423246525922009 no 1970 0.411118093161582 656 5605015
SGTC_2246 7293507 91.5585 µM -0.225015589365131 0.423121507578406 no 1971 0.410983573334265 639 887656
SGTC_2826 7992541 19.48 µM -0.225069064120754 0.423102176633519 no 1972 0.410962773414541 671 2985066
SGTC_1500 4488-1866 171 µM -0.226681919513423 0.422519222021454 no 1973 0.41033554365386 682 2900003
SGTC_2282 7944268 200 µM -0.227524366815256 0.422214793070041 no 1974 0.410008012023898 686 2970414
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.227661732931134 0.422165158493778 no 1975 0.40995461196185 651 6857784
SGTC_403 arphamenine a 50 µM -0.228268999278305 0.421945749423458 no 1976 0.40971856168126 653 5487158 An arginine aminopeptidase inhibitor.
SGTC_1660 st012960 28.1 µM -0.229499373092886 0.421501282120031 no 1977 0.409240403912516 672 24207266
SGTC_1861 st057647 17.4 µM -0.229808455051286 0.421389643271416 no 1978 0.409120307184825 656 688668
SGTC_887 0885-0007 9.62 µM -0.231423660765293 0.420806342086691 no 1979 0.40849284269127 650 5719458
SGTC_2068 5226020 147 µM -0.232175383559791 0.420534930723315 no 1980 0.408200898234705 676 1810509
SGTC_822 1487-0950 154 µM -0.232858279516154 0.420288402199763 no 1981 0.407935728023928 657 1958375
SGTC_2078 5212016 200 µM -0.233002608825982 0.420236302666562 no 1982 0.407879689984674 658 1899708
SGTC_772 k072-0172 35.3 µM -0.234002954625488 0.419875239494862 no 1983 0.407491342440326 642 5861980
SGTC_2129 girgensonine 121.053 µM -0.23477582274551 0.419596327902415 no 1984 0.407191366978754 673 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1007 4101-0031 70 µM -0.236246263117255 0.419065789016528 no 1985 0.40662079127166 683 1146276
SGTC_2081 5214970 32.255 µM -0.237415109259583 0.418644171062211 no 1986 0.406167384640154 659 2063512
SGTC_2255 7941087 197.44 µM -0.2385000201414 0.418252913246356 no 1987 0.405746649865901 669 935561
SGTC_1826 st055655 41.6 µM -0.240343663721484 0.41758821487002 no 1988 0.405031924029736 642 676168
SGTC_183 3914-0051 30.55 µM -0.2405420696316 0.417516696555166 no 1989 0.404955026783786 637 1596232
SGTC_257 daunorubicin 18.5 µM -0.240926056108694 0.417378290760214 no 1990 0.404806213505745 646 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1619 st003326 88.7 µM -0.241766953595406 0.417075229703614 no 1991 0.404480373288725 622 2849032
SGTC_584 0986-0246 15.4 µM -0.241906001784307 0.417025121213355 no 1992 0.404426499741583 675 53315 YDR232W HEM1
SGTC_2968 9090663 33.37 µM -0.243396595536249 0.41648804404906 no 1993 0.403849090447176 702 25236811
SGTC_2489 cantharidin 73.42 µM -0.244037151480962 0.416257292589728 no 1994 0.403601023425985 655 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_760 0568-0725 82.9 µM -0.244098562169222 0.41623517174968 no 1995 0.403577243047596 677 3916171
SGTC_1554 st069299 38.7 µM -0.244570651987496 0.416065128402941 no 1996 0.403394445175491 652 24207999
SGTC_1768 st044301 37.178 µM -0.24488760712743 0.415950972261226 no 1997 0.403271728832336 672 3931349
SGTC_1626 st003712 1.76 µM -0.244996455695403 0.415911770454204 no 1998 0.403229587846661 684 24207035
SGTC_2262 9014885 67.46 µM -0.246014857704086 0.415545033601038 no 1999 0.402835365559003 660 6457424
SGTC_3051 9093778 49.47 µM -0.246644659256474 0.415318272486372 no 2000 0.402591619473598 672 17217378
SGTC_3153 9100258 49.47 µM -0.246868011660096 0.415237860846079 no 2001 0.402505186613413 686 25236848
SGTC_2917 7979103 53.79 µM -0.247246075834513 0.415101757753261 no 2002 0.402358894291541 688 2980565
SGTC_638 3970-0837 4.09 µM -0.24843222988714 0.414674808523377 no 2003 0.401899999600409 645 4118451 YLR208W SEC13
SGTC_3069 9117009 49.47 µM -0.249720859546534 0.414211088021697 no 2004 0.401401612795345 642 41904981
SGTC_2802 7925815 54.55 µM -0.250092638668973 0.414077323446682 no 2005 0.401257854312244 654 1262923
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.250779526226091 0.413830210403382 no 2006 0.400992285778248 661 1377
SGTC_291 SEC14.278 35.5 µM -0.251641327080346 0.413520219232833 no 2007 0.400659155941212 652 1068044
SGTC_3342 9147791 14.508 µM -0.253946666626172 0.412691250260634 no 2008 0.399768380727675 653 1838168
SGTC_1505 k297-0037 20.6 µM -0.254130203731021 0.412625269475955 no 2009 0.399697484972899 652 4089396
SGTC_2623 humulene 100 µM -0.254385248708844 0.412533586023776 no 2010 0.399598973020811 669 6187145 An anti-inflammatory.
SGTC_253 dyclonine 31.25 µM -0.254577250444441 0.4124645684758 no 2011 0.399524815942474 646 3180 An oral anasthetic.
SGTC_1329 1447-1697 50.6 µM -0.260136768660616 0.41046730871561 no 2012 0.397379138338447 660 2840515
SGTC_1194 1488-0194 225 µM -0.260191020605642 0.410447830021971 no 2013 0.397358215157398 648 1391452
SGTC_2235 salicylic acid 500 µM -0.262450161583231 0.409636901590943 no 2014 0.396487202102975 655 338 A COX inhibitor and kinase inhibitor.
SGTC_188 3229-0966 278.469 µM -0.263503972066153 0.409258763711392 no 2015 0.396081081218481 665 5722370
SGTC_1223 0764-0573 147 µM -0.264615809224904 0.408859895692948 no 2016 0.395652720076241 655 1609797
SGTC_78 0336-0123 156.75 µM -0.265624109387771 0.408498252822374 no 2017 0.395264357912517 645 6765896
SGTC_604 1000-0114 314 µM -0.266199158372034 0.408292037235256 no 2018 0.395042915585118 685 1572745
SGTC_518 1021-0119 62.6 µM -0.266531034923931 0.408173036113549 no 2019 0.394915130561586 691 1097762
SGTC_2179 6298986 200 µM -0.266685072443825 0.408117805688983 no 2020 0.394855824130678 667 738374
SGTC_952 1185-0122 232 µM -0.266861751108408 0.408054459489768 no 2021 0.394787803566946 656 678600
SGTC_414 piperonyl butoxide 100 µM -0.267937221617111 0.407668913218219 no 2022 0.39437382106516 671 5794 A potent inhibitor of cytochrome P450.
SGTC_2575 plumbagin 510 nM -0.269471561487094 0.40711902135653 no 2023 0.393783411859055 696 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1049 3226-0134 66 µM -0.271374399462694 0.406437317847933 no 2024 0.39305154489461 662 5702385
SGTC_259 usnic acid 108.925 µM -0.272856641073233 0.405906491901533 no 2025 0.392481708794128 713 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_505 gw-5074 63.9 µM -0.273793353870118 0.405571121908096 no 2026 0.392121715689435 667 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_130 0136-0219 337.655 µM -0.274045509829194 0.405480854686401 no 2027 0.392024824041935 705 234244
SGTC_959 1222-0044 107 µM -0.27463171135735 0.405271024694536 no 2028 0.391799600314555 672 6083612
SGTC_2572 astragaloside iv 100 µM -0.275117556707164 0.405097137682048 no 2029 0.391612961777662 660 45006101 An anti-inflammatory agent.
SGTC_1519 esterone 74 µM -0.275148421590616 0.40508609158463 no 2030 0.391601105808522 660 698 A steroid.
SGTC_1143 3454-2408 5.08 µM -0.275226554843508 0.405058129156338 no 2031 0.391571093333502 664 X1143
SGTC_649 1123-0311 367 µM -0.275867007581548 0.40482894139542 no 2032 0.391325107544462 681 693629 YIL048W NEO1
SGTC_925 2064-1272 59.6 µM -0.276456093114477 0.404618164347946 no 2033 0.39109888929411 690 6815817
SGTC_3182 9108849 49.47 µM -0.278548246552796 0.403869807966263 no 2034 0.390295767208631 665 17133045
SGTC_82 0054-0107 293.755 µM -0.279976399250901 0.40335916428359 no 2035 0.389747805869969 678 3104697
SGTC_3091 9116372 49.47 µM -0.281296521719108 0.402887293874873 no 2036 0.389241488959434 672 17169793
SGTC_1940 st075990 51.1 µM -0.281639027248168 0.402764890261125 no 2037 0.389110155811485 688 1084979
SGTC_722 3534-0461 190 µM -0.281761261509431 0.402721208848905 no 2038 0.389063288363653 661 658262
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.282241680452745 0.402549538983423 no 2039 0.388879100255017 656 88881 An O-methylated flavonoid and antioxidant.
SGTC_1655 st012546 55.1 µM -0.28231393482834 0.402523721686706 no 2040 0.388851400765798 677 720985 YLR208W SEC13
SGTC_3230 9131665 49.47 µM -0.282352127754554 0.402510075098644 no 2041 0.388836759326487 677 15943720
SGTC_2829 7992743 58.44 µM -0.283017180122272 0.402272466496948 no 2042 0.388581833677752 689 16462845
SGTC_2005 4024620 188 µM -0.285175039797251 0.40150175969652 no 2043 0.387755021044984 687 236743
SGTC_2138 5575593 77.673 µM -0.285211477544913 0.401488748775343 no 2044 0.387741063794373 691 762213
SGTC_709 3807-1509 243 µM -0.285290638643689 0.401460482892632 no 2045 0.38771074213207 698 1886677 YPL242C IQG1
SGTC_1600 coumarin 106 71.1 µM -0.287633568059022 0.400624132216167 no 2046 0.386813623326649 713 100336 A hepatotoxic, DNA x-linker.
SGTC_2464 5717415 7.67 µM -0.287659117610912 0.400615014348483 no 2047 0.386803843604872 679 5285744
SGTC_43 0570-0105 72.5 µM -0.288382582813211 0.400356853841582 no 2048 0.386526949292307 679 1114046 YDL195W SEC31
SGTC_2755 lomerizine 42.69 µM -0.288522791189052 0.400306827074759 no 2049 0.386473293538812 666 3949 A calcium channel blocker.
SGTC_2959 9079155 11 µM -0.288588695302357 0.400283312855549 no 2050 0.386448073720784 686 16189457
SGTC_575 k072-0246 11.9 µM -0.288805193309587 0.400206070121325 no 2051 0.386365228848939 667 6796779
SGTC_986 1493-0483 84 µM -0.28928315786575 0.40003555448317 no 2052 0.386182349842019 699 40079
SGTC_694 1315-0438 43.2 µM -0.291032035013172 0.399411798708615 no 2053 0.385513409510471 700 6793154
SGTC_883 0850-0245 24.6 µM -0.291647235353765 0.399192441860011 no 2054 0.38527817803469 660 6823229 YPR165W RHO1
SGTC_375 3970-0961 9.27 µM -0.29170633419725 0.399171371153336 no 2055 0.38525558288769 662 2898222
SGTC_3077 9117319 49.47 µM -0.291828503576215 0.399127814630835 no 2056 0.385208875339322 678 17154678
SGTC_2488 5268135 45.7 µM -0.293338712036199 0.398589490390505 no 2057 0.384631633235392 706 1270356 YLR208W SEC13
SGTC_383 2324-0395 7.37 µM -0.293552920036605 0.398513150065702 no 2058 0.384549777878523 693 3146421
SGTC_2557 derrustone 83.84 µM -0.294655786041674 0.398120167687872 no 2059 0.38412842095878 727 629853 An antioxidant.
SGTC_784 4579-0127 173 µM -0.295016995369198 0.397991481021786 no 2060 0.383990448394185 711 1948547
SGTC_1819 st053448 58.6 µM -0.295695688509193 0.397749715634411 no 2061 0.383731245051383 667 2857616
SGTC_1265 0819-1001 68.8 µM -0.295699512059813 0.397748353712928 no 2062 0.383729784925863 680 3106768
SGTC_2343 7990716 14.84 µM -0.296710449156374 0.397388308894803 no 2063 0.383343789418387 649 6456862
SGTC_2529 gangaleoidin 93.61 µM -0.29853002805692 0.396740487084531 no 2064 0.382649330631831 663 4565183
SGTC_2253 7938677 135.83 µM -0.298860236060574 0.39662295413873 no 2065 0.382523344121331 677 2301972
SGTC_2540 epiandrosterone 100 µM -0.300602449405684 0.396002993271902 no 2066 0.381858831724371 668 441302 A steroid.
SGTC_2521 angolensin 13.4 µM -0.300888165710218 0.395901347124945 no 2067 0.381749887399577 665 821428 A flavenoid.
SGTC_51 1013-0126 23.419 µM -0.301454642162052 0.395699838963896 no 2068 0.381533916244134 717 1627850
SGTC_1877 wortmannin 25 µM -0.302835692910179 0.395208685693426 no 2069 0.381007540424528 696 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2936 9038235 15.59 µM -0.303016173525714 0.39514451231981 no 2070 0.380938768005117 665 4749415
SGTC_568 1193-0097 7.48 µM -0.306713427651674 0.393830510334097 no 2071 0.379530754157192 685 3646150
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.307402416673488 0.393585777103441 no 2072 0.379268544473666 667 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1384 3089-0840 101 µM -0.308586114601464 0.393165418345879 no 2073 0.378818192322616 679 1069836
SGTC_2094 5332512 191.667 µM -0.308684960833615 0.39313032136913 no 2074 0.378780592514356 713 755774
SGTC_1042 0350-0096 82 µM -0.310467086146819 0.392497697800171 no 2075 0.378102892578694 668 3122515
SGTC_275 trichlorophene 5.69 µM -0.311438944931655 0.392152824330017 no 2076 0.377733475591311 680 62616
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.311642869895226 0.392080470330292 no 2077 0.377655975067338 732 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_789 1309-1135 70.6 µM -0.311949752980841 0.391971593104279 no 2078 0.377539355177662 669 3092424
SGTC_759 3486-0358 89.3 µM -0.313117299854151 0.391557443464486 no 2079 0.37709577305674 711 875103
SGTC_1731 st035964 63 µM -0.31417436832698 0.391182588453489 no 2080 0.376694304452439 720 6739575
SGTC_1909 st060837 51.5 µM -0.314384160481843 0.391108204485291 no 2081 0.376614642424172 717 678937
SGTC_2154 5570129 200 µM -0.31441240888604 0.391098189026984 no 2082 0.376603916374908 712 673366
SGTC_2084 5306078 60.6385 µM -0.315802645695515 0.390605370588577 no 2083 0.376076154917967 706 679340
SGTC_2608 thymoquinone 42.66 µM -0.318010138328842 0.389823208247672 no 2084 0.3752386232723 682 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1852 st056254 31.4 µM -0.318327546135804 0.389710780400336 no 2085 0.375118245709342 689 442583
SGTC_840 0245-0196 390 µM -0.318578173845954 0.389622013004052 no 2086 0.37502320322797 671 3827528
SGTC_2784 7567673 72.73 µM -0.318789087524243 0.389547315996668 no 2087 0.37494322689292 687 3471247
SGTC_2663 amphotericin b 100 µM -0.319614676585769 0.389254965352171 no 2088 0.374630223614067 687 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1425 4048-4433 7.33 µM -0.321362946281936 0.388636089890124 no 2089 0.373967679829138 709 23734946
SGTC_114 0364-0001 490.298 µM -0.321634909717884 0.388539842058842 no 2090 0.373864646933303 683 4003655
SGTC_2196 6573537 42.6665 µM -0.322892130481711 0.3880950007809 no 2091 0.373388468168375 721 2903087
SGTC_2283 7944793 200 µM -0.323900422324386 0.387738343833208 no 2092 0.373006712120582 663 2970533
SGTC_757 1066-0008 322 µM -0.327821570572041 0.386352242658628 no 2093 0.37152328841479 690 6842497
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.32787249903346 0.386334249263295 no 2094 0.3715040339772 712 364106
SGTC_1033 k072-0102 21.3 µM -0.331070893887793 0.385204724337344 no 2095 0.37029546818199 720 5965931
SGTC_1365 1672-3266 55.4 µM -0.331141973777437 0.385179633232011 no 2096 0.37026862397127 714 6415873
SGTC_1892 st058411 7.36 µM -0.331200727000473 0.385158893786264 no 2097 0.370246435557581 691 3934738
SGTC_3145 9085516 49.47 µM -0.332528985603751 0.384690116254123 no 2098 0.369744928187976 675 25236195
SGTC_2426 5582046 32.21 µM -0.333133222017267 0.384476921001574 no 2099 0.36951686135436 705 2251934
SGTC_1474 0330-0125 5.35 µM -0.333151458754368 0.384470487000426 no 2100 0.369509978677609 691 X1474
SGTC_2719 novobiocin 32.65 µM -0.334887743241231 0.383858064187735 no 2101 0.368854884135061 703 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3229 9132204 49.47 µM -0.337117217131434 0.383072108804813 no 2102 0.368014269474786 680 17682924
SGTC_2963 9082507 9 µM -0.338385116118208 0.382625351358522 no 2103 0.367536494455581 723 16459611
SGTC_1349 flufenamic acid 69 µM -0.33884049601944 0.382464931577689 no 2104 0.36736494627538 691 3371 A non-steroidal anti-inflammatory.
SGTC_412 gemfibrozil 100 µM -0.339671944546736 0.38217208358544 no 2105 0.367051795920231 681 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2620 irigenin 100 µM -0.339920992703168 0.382084378392761 no 2106 0.366958013546826 673 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1355 1499-0035 1.68 µM -0.342080657303213 0.381324081670966 no 2107 0.366145096781534 702 1548538
SGTC_39 0986-0283 58.349 µM -0.34307877291766 0.380972855662177 no 2108 0.365769599919165 677 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3297 9117502 71.43 µM -0.343611263499534 0.380785518115644 no 2109 0.365569326452402 679 7453720
SGTC_1220 1838-0075 193 µM -0.344312277954476 0.380538934158939 no 2110 0.365305725845189 691 5529645
SGTC_1954 st077032 68.9 µM -0.344788502781609 0.380371448308911 no 2111 0.365126688567153 740 698907
SGTC_2452 5863136 48.41 µM -0.344982749862551 0.380303139035361 no 2112 0.365053669589179 705 2184096
SGTC_843 0310-0051 143 µM -0.345080184103092 0.380268876542898 no 2113 0.365017045148184 723 2065037
SGTC_417 st075190 100 µM -0.345833003785273 0.38000418118607 no 2114 0.36473411018757 715 222757
SGTC_2630 antimycin a 100 µM -0.345955573711063 0.379961090272702 no 2115 0.364688051254664 718 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3286 9117135 37.221 µM -0.348939971514788 0.378912350859585 no 2116 0.363567188003002 686 3438150
SGTC_1866 st057638 64 µM -0.349422612137844 0.378742830863382 no 2117 0.363386029927388 694 688802
SGTC_1216 1165-0504 9.65 µM -0.349921379428504 0.378567671134534 no 2118 0.363198850840778 702 6304004
SGTC_2219 9098279 200 µM -0.351263954825377 0.378096302457082 no 2119 0.362695166996496 702 902349
SGTC_655 k060-0012 42 µM -0.351726820363454 0.377933835672306 no 2120 0.36252157224775 705 5994525
SGTC_2951 9072950 58.06 µM -0.351964462146033 0.377850431287904 no 2121 0.362432457199516 703 16488155
SGTC_1048 3161-0300 24.5 µM -0.352264237130838 0.377745228332032 no 2122 0.362320052994438 670 2165101
SGTC_2330 7979373 200 µM -0.352907313343119 0.377519577931377 no 2123 0.362078963953297 681 1863007
SGTC_1632 st005650 90 µM -0.353284054359193 0.377387401875419 no 2124 0.361937749289347 686 2759605
SGTC_609 0986-0026 86.3 µM -0.354020875733915 0.377128936520738 no 2125 0.361661619250855 697 2848610
SGTC_457 grayanotoxin iii 135 µM -0.354654192008432 0.376906823108126 no 2126 0.361424336173079 710 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1934 st074720 32.6 µM -0.355479187307354 0.376617546114844 no 2127 0.361115317114575 681 17250992
SGTC_170 4197-0004 226 µM -0.356304712068304 0.376328152804102 no 2128 0.360806190434713 691 218692
SGTC_284 0988-0104 32.6 µM -0.357177929193071 0.376022116261115 no 2129 0.360479303779675 703 4666532
SGTC_619 1652-1634 108 µM -0.358068846497858 0.375709956670078 no 2130 0.360145896166283 712 5400454
SGTC_853 0419-0306 21 µM -0.358132813204543 0.375687547143539 no 2131 0.360121962021188 699 762713
SGTC_2497 7-hydroxyflavone 100 µM -0.358935984114153 0.37540620710871 no 2132 0.359821489737413 697 5281894
SGTC_1967 st070177 51.4 µM -0.359846433065079 0.375087369131851 no 2133 0.359480988674629 742 5729214
SGTC_2761 levamisole 97.89 µM -0.365820234961359 0.372997477982704 no 2134 0.357249609809089 734 26879 An alkaline phosphatase inhibitor.
SGTC_84 0443-0269 128.823 µM -0.366565457527057 0.372737027853101 no 2135 0.356971589054943 724 6150058
SGTC_574 1315-0397 40 µM -0.36706800424678 0.372561424085161 no 2136 0.356784146427644 696 6794277
SGTC_139 0099-0334 718.624 µM -0.367407223839755 0.372442906318252 no 2137 0.35665764198913 702 97690
SGTC_3039 9090270 49.47 µM -0.368259041466953 0.372145348467506 no 2138 0.356340044988571 685 17173750
SGTC_939 1165-0479 45.3 µM -0.369231007122895 0.371805913622161 no 2139 0.35597777293573 714 1377347
SGTC_1995 st072814 61.1 µM -0.37048799482753 0.371367089670595 no 2140 0.355509459965713 693 5769371
SGTC_532 1548-0774 215 µM -0.370712096553512 0.371288871597098 no 2141 0.355425989793363 751 5932993
SGTC_374 0880-0231 82.3 µM -0.370835149894613 0.37124592463344 no 2142 0.355380159612025 714 6833587
SGTC_3219 9131112 49.47 µM -0.375065840158676 0.369770345833503 no 2143 0.35380575063115 716 17612988 YMR079W SEC14
SGTC_173 1273-0061 2.693 µM -0.375493961191082 0.369621132287083 no 2144 0.353646568360824 714 2847414 YPL266W DIM1
SGTC_1442 4112-3290 3 µM -0.376255694265377 0.369355693081376 no 2145 0.353363407060498 724 704353
SGTC_3288 9119690 36.221 µM -0.376476547805617 0.36927874444308 no 2146 0.353281323685046 732 17595618 YKL019W RAM2
SGTC_1465 k213-0056 144 µM -0.376595515082926 0.369237296655147 no 2147 0.353237110623766 719 24048857 YMR208W ERG12
SGTC_2911 7942208 15.64 µM -0.377178768790332 0.369034115083563 no 2148 0.353020378581315 702 1243384
SGTC_1224 0823-0416 294 µM -0.377205903284902 0.369024663433423 no 2149 0.353010296797443 723 3598164
SGTC_1210 3013-0140 750 nM -0.378031760815672 0.368737033688488 no 2150 0.352703499969888 725 905973
SGTC_1516 st013856 110 µM -0.379587454953333 0.368195416155495 no 2151 0.352125837268512 717 5281404 A mutagen and neurotoxin.
SGTC_2838 9002687 71.43 µM -0.382539463415485 0.367168390082887 no 2152 0.351030631513457 730 6457060
SGTC_3281 9140613 49.47 µM -0.382841939286453 0.367063209958321 no 2153 0.35091848155551 686 16013766
SGTC_307 1501-1223 22.3 µM -0.384341279508512 0.366541990876756 no 2154 0.350362758224739 728 2830329
SGTC_3008 9078912 71.4286 µM -0.385923814754115 0.365992117409296 no 2155 0.349776546362224 736 16648731
SGTC_731 3966-0296 387 µM -0.38684796439532 0.365671136176984 no 2156 0.349434382956805 705 660956
SGTC_1578 josamycin 24.2 µM -0.387741920657295 0.365360731356901 no 2157 0.349103514924396 734 5282165 A P450 substrate.
SGTC_1250 0485-0349 40.2 µM -0.388774116629642 0.365002435806585 no 2158 0.348721624733738 731 6842794 YDL195W SEC31
SGTC_651 3253-0966 34.4 µM -0.390368140433556 0.364449350344352 no 2159 0.348132171527801 711 781462
SGTC_1016 4226-1401 38 µM -0.390540765520129 0.364389470766079 no 2160 0.348068358571979 721 2901613
SGTC_2242 6630449 61.2675 µM -0.390817359783041 0.364293533628354 no 2161 0.347966121119152 715 691249 YDR170C SEC7
SGTC_1484 3473-2379 286 µM -0.390920187263162 0.364257869929144 no 2162 0.347928115846617 719 671917
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.390981362810384 0.364236652945344 no 2163 0.347905505948801 706 17037758
SGTC_3324 9138759 60.749 µM -0.391996560170153 0.363884621645779 no 2164 0.347530377708125 722 45595710
SGTC_1278 0874-0585 172 µM -0.393175133436522 0.363476081957361 no 2165 0.347095067245415 701 766306
SGTC_162 k030-0015 37.8 µM -0.397281632349055 0.36205382378118 no 2166 0.345579895257381 723 1809920 YMR134W ERG29
SGTC_2650 prasterone 100 µM -0.397304988662851 0.362045739902999 no 2167 0.345571284538358 709 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1414 3917-0015 5.4 µM -0.399256462366303 0.361370530993398 no 2168 0.344852121796657 738 6618702
SGTC_1447 4239-0816 81.9 µM -0.399645628388851 0.361235931294434 no 2169 0.344708772119755 734 1341554
SGTC_1126 isoteolin 1.0172 µM -0.400099822241697 0.361078862334978 no 2170 0.344541497572696 701 133323
SGTC_824 1304-0008 100 µM -0.400764513547279 0.360849041536352 no 2171 0.344296753950765 704 768245
SGTC_2031 5180455 200 µM -0.401541764556399 0.360580366301016 no 2172 0.344010647807448 719 29949
SGTC_2108 5365811 200 µM -0.402329045415516 0.36030829415838 no 2173 0.343720940691369 696 780283
SGTC_1011 4112-3381 17.4 µM -0.402690632613892 0.360183358882873 no 2174 0.343587912961446 753 2877139
SGTC_1212 0520-0165 585 µM -0.403142408254688 0.360027282762468 no 2175 0.343421732172605 795 5403258
SGTC_2226 7298446 200 µM -0.405155038863481 0.359332257788188 no 2176 0.342681775868334 740 3283010
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.405353733343648 0.359263667495411 no 2177 0.342608757263009 732 521171
SGTC_2045 5106652 78.05 µM -0.406298378379445 0.358937633545549 no 2178 0.342261688378263 722 673349
SGTC_155 k072-0202 43.6 µM -0.411283114174208 0.357218912621554 no 2179 0.340432474921649 745 5857737
SGTC_158 k038-0087 26.446 µM -0.411725432283841 0.357066541991704 no 2180 0.340270340962015 693 X158
SGTC_2403 6032726 181.2 µM -0.412021931063701 0.356964416256508 no 2181 0.340161674348648 720 2881040
SGTC_3223 9129970 49.47 µM -0.412881859899354 0.356668281241874 no 2182 0.339846586087165 704 17248386
SGTC_794 k038-0031 316 µM -0.413412694373809 0.35648552006221 no 2183 0.339652137777198 721 6624242
SGTC_1989 st071868 50.2 µM -0.41407489506679 0.35625757695795 no 2184 0.339409628938146 738 16414057
SGTC_1177 0983-0204 23.6 µM -0.414770753460456 0.35601810351351 no 2185 0.33915486573625 721 766818
SGTC_531 3788-1495 174 µM -0.415294927298941 0.355837751269295 no 2186 0.338963007123245 694 2896655
SGTC_2231 micatex 6.853 µM -0.416167892682622 0.355537462101785 no 2187 0.33864357620222 719 20737 An antifungal of unknown mechanism.
SGTC_3135 9127742 49.47 µM -0.417560846753413 0.355058489044527 no 2188 0.338134114108748 713 3643468
SGTC_724 3910-0327 137 µM -0.417978973348429 0.354914759115123 no 2189 0.337981245336219 768 2885483
SGTC_1302 1159-0335 255 µM -0.418511627850424 0.354731690420595 no 2190 0.337786543393295 724 649284
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.41878251894195 0.354638600385978 no 2191 0.337687540839861 729 688667
SGTC_1982 st072467 71.9 µM -0.420001459857313 0.354219826423375 no 2192 0.337242193617029 739 3163533
SGTC_168 3970-0862 530.542 µM -0.420535699802942 0.354036340819328 no 2193 0.337047077726619 731 3135186
SGTC_35 0133-0054 64.071 µM -0.421667140234064 0.353647857639958 no 2194 0.336633996173893 744 99677
SGTC_2096 5468907 200 µM -0.423852322263731 0.352898000998711 no 2195 0.335836758519091 718 759785
SGTC_2450 5739737 12.93 µM -0.424209064650692 0.352775637126311 no 2196 0.335706675303695 729 2262825
SGTC_2516 gossypol 71.55 µM -0.425612436168367 0.352294423732667 no 2197 0.335195138429029 749 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3102 9121669 49.47 µM -0.426017436747292 0.352155593729396 no 2198 0.335047570179462 733 41905072
SGTC_3132 9126706 49.47 µM -0.427700308255115 0.351578934005781 no 2199 0.334434662717078 779 850858
SGTC_3301 9125354 19.7965 µM -0.428155153666637 0.351423133340472 no 2200 0.334269082132099 704 41905162
SGTC_2398 5228213 48.84 µM -0.428769341343857 0.351212791915781 no 2201 0.334045546227112 737 80771 YMR134W ERG29
SGTC_2472 5377652 49.4 µM -0.42884488039663 0.351186925131842 no 2202 0.334018057569332 756 1610903
SGTC_894 0960-0238 55.9 µM -0.429000365536743 0.351133684636288 no 2203 0.333961479337038 744 6741907 YDL195W SEC31
SGTC_2713 st079149 53.4 µM -0.429308662788601 0.351028127572049 no 2204 0.33384930670007 712 3103253
SGTC_1006 4099-6547 255 µM -0.431171441661579 0.350390580538419 no 2205 0.333171858720279 737 3146833
SGTC_3116 9124943 49.47 µM -0.432288595349369 0.350008430075071 no 2206 0.332765837510351 705 41905195 YPL160W CDC60
SGTC_1076 itraconazole 331 nM -0.432964556952576 0.349777274155934 no 2207 0.332520259453168 711 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.433704176987527 0.34952441300017 no 2208 0.332251636509601 741 77254
SGTC_151 3013-0144 2.285 µM -0.43445900123929 0.34926642265448 no 2209 0.331977580369151 740 906558 YHR107C CDC12
SGTC_3011 9081274 71.4286 µM -0.435592059548779 0.348879286951908 no 2210 0.331566366458995 717 6625322
SGTC_3163 9099914 49.47 µM -0.435967719656592 0.348750968640335 no 2211 0.331430075204647 730 16268368
SGTC_225 nsc-122657 1.016 µM -0.436052915795099 0.348721869674114 no 2212 0.331399168749142 756 275685
SGTC_948 3448-0295 75.3 µM -0.436984756807665 0.348403655044676 no 2213 0.33106120139581 730 678569
SGTC_936 3005-4620 401 µM -0.437782541340273 0.348131304138194 no 2214 0.330771964006035 759 777207
SGTC_2277 7947813 106.88 µM -0.439868599885817 0.347419527436511 no 2215 0.330016139600958 758 1246798
SGTC_85 0868-0259 160.055 µM -0.440265254012963 0.347284247241008 no 2216 0.329872501536242 736 83173
SGTC_564 3555-0129 330 µM -0.441168713971642 0.346976191889178 no 2217 0.329545430461757 727 563260
SGTC_777 1315-0167 517 µM -0.442255895830846 0.346605626401126 no 2218 0.329152021091663 713 4221767
SGTC_2669 eugenol 100 µM -0.443047567959473 0.346335877584605 no 2219 0.328865664317636 730 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_224 benfluorex 43.875 µM -0.444013749591178 0.346006773213073 no 2220 0.328516321559938 747 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.444628371555609 0.345797478898368 no 2221 0.328294170358288 733 71034 A hepatoprotective.
SGTC_12 0849-0099 9.267 µM -0.444770992211342 0.345748919692442 no 2222 0.328242629703432 759 6071388
SGTC_2466 5983409 37.09 µM -0.446173652657612 0.345271479875792 no 2223 0.32773590663558 735 2879657
SGTC_3338 9144300 39.5675 µM -0.447482040094386 0.344826350700126 no 2224 0.327263526260143 735 4901274
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.447814667131765 0.34471322117875 no 2225 0.327143478604621 740 75037 A free radical scavenger.
SGTC_1051 3253-3903 78 µM -0.449995419031599 0.343971871681512 no 2226 0.326356871852245 737 5509239
SGTC_280 3448-3607 3.04 µM -0.451288685881235 0.34353250683986 no 2227 0.325890749098614 741 626179
SGTC_924 2046-0044 21.3 µM -0.452886234503423 0.342990059357531 no 2228 0.325315331826313 737 3623589
SGTC_1926 methyl fluorone black 53.6 µM -0.454670325467939 0.342384653756949 no 2229 0.324673216259112 723 72721 Reacts with homocysteine.
SGTC_2847 9005661 71.43 µM -0.454703882195018 0.342373270637968 no 2230 0.324661143777231 741 2991449
SGTC_515 4092-1064 102 µM -0.454990543680623 0.34227603511473 no 2231 0.324558020978636 787 717353
SGTC_739 1486-1183 203 µM -0.456026518295034 0.341924719925128 no 2232 0.324185454555335 734 4346692
SGTC_2882 9058044 58.44 µM -0.456371759806955 0.34180767351236 no 2233 0.324061334803237 740 18076804
SGTC_899 1083-0020 478 µM -0.457086358359928 0.341565453173782 no 2234 0.323804487526609 770 767123
SGTC_1620 st003704 16.5 µM -0.45728805907074 0.341497096497471 no 2235 0.323732005663786 749 2834414
SGTC_3253 9135987 49.47 µM -0.458013305187957 0.341251352457345 no 2236 0.323471441160138 743 4182430
SGTC_973 1325-0077 65.9 µM -0.458300022023625 0.341154219232704 no 2237 0.323368454157396 745 2835149
SGTC_803 4488-1585 147 µM -0.459299509490045 0.340815697656884 no 2238 0.323009549980758 748 747204
SGTC_1413 3910-0535 34.4 µM -0.460964513802372 0.340252053386239 no 2239 0.322412032443719 735 2876951
SGTC_303 1348-1668 34.2 µM -0.461538214605769 0.340057924346486 no 2240 0.322206255443857 753 5380509
SGTC_115 0527-0192 112.043 µM -0.461579427530302 0.340043980337047 no 2241 0.322191475145476 766 4233931
SGTC_199 4063-0024 41.6 µM -0.463003114693303 0.339562423478094 no 2242 0.321681067266054 743 306215
SGTC_2290 7904846 200 µM -0.464205172334468 0.339156035776972 no 2243 0.321250377906429 723 2962154
SGTC_1315 1237-0019 3.69 µM -0.464536530336327 0.339044044219764 no 2244 0.321131696732499 740 825140
SGTC_628 1636-0253 16 µM -0.464684236133684 0.338994127562052 no 2245 0.32107879942172 758 4456143
SGTC_2353 9059630 146.67 µM -0.464690118319128 0.338992139756569 no 2246 0.321076692932368 734 4779114
SGTC_3004 9076122 71.4286 µM -0.465119233744781 0.338847138063253 no 2247 0.320923036489149 765 44782551
SGTC_3198 9112019 49.47 µM -0.465316285152331 0.33878056074181 no 2248 0.32085248714864 796 45595555
SGTC_3086 9117350 49.47 µM -0.465522351988158 0.33871094278508 no 2249 0.320778716978128 737 2679265
SGTC_2241 6772625 37.8075 µM -0.465548486619462 0.338702113812185 no 2250 0.32076936150851 740 2285411
SGTC_68 0986-0284 82.829 µM -0.466351695442401 0.338430811770054 no 2251 0.320481890666587 701 423278 YIL048W NEO1
SGTC_535 2293-4129 48.2 µM -0.466582334112912 0.338352923803369 no 2252 0.320399364285243 780 396118 YIL048W NEO1
SGTC_1409 3909-8004 61.9 µM -0.466943510211596 0.338230966514308 no 2253 0.32027014726773 724 2119279
SGTC_2877 9040724 71.43 µM -0.467070588015547 0.338188060555049 no 2254 0.320224688159451 754 6463895
SGTC_478 N-arachidonylglycine 10 µM -0.468364465377654 0.337751321520803 no 2255 0.31976198752541 715 5283389
SGTC_3292 9120825 59.784 µM -0.470065516312548 0.337177476294632 no 2256 0.319154105056849 772 24824900
SGTC_1455 4262-0120 131 µM -0.470922500710683 0.336888518114536 no 2257 0.318848039642904 734 1529587
SGTC_1929 genistein trimethyl ether 50.5 µM -0.471309318736675 0.336758122245257 no 2258 0.318709930988361 744 136420
SGTC_91 0417-1751 58.384 µM -0.473560057067001 0.335999790851306 no 2259 0.317906832285647 759 6795624
SGTC_3265 9137266 49.47 µM -0.474954991723905 0.33553013624681 no 2260 0.317409526969114 718 17224265
SGTC_524 r073-0010 27.8 µM -0.475024937626196 0.335506593215786 no 2261 0.317384599363408 761 2772106
SGTC_3168 9103419 49.47 µM -0.476294188734238 0.33507948934943 no 2262 0.316932402451106 760 16649256
SGTC_2044 5102272 200 µM -0.476380375892541 0.335050495034321 no 2263 0.316901706398882 738 592666
SGTC_1527 coumarin 137 µM -0.481118114746174 0.333458183454292 no 2264 0.315216277092238 800 323 A hepatotoxic, DNA x-linker.
SGTC_1789 tunicamycin 25 nM -0.48276237493741 0.332906261178699 no 2265 0.314632234442357 764 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1 0258-0098 57.368 µM -0.484351633918626 0.332373144766003 no 2266 0.31406816868547 731 6790032 YDR047W HEM12
SGTC_1436 4092-1007 8.32 µM -0.486026093587188 0.331811814490877 no 2267 0.313474332756709 719 2881121
SGTC_861 0443-0273 110 µM -0.487964256621709 0.331162553961957 no 2268 0.312787579469788 750 6149169
SGTC_2714 st079313 56.9 µM -0.489734139724492 0.330570108142505 no 2269 0.31216102019782 759 2939799
SGTC_2356 9061756 188.97 µM -0.489823922843661 0.330540065682766 no 2270 0.3121292503807 723 20104043
SGTC_1902 st060212 70.5 µM -0.490172211246929 0.330423534729809 no 2271 0.312006021518881 734 688944
SGTC_268 camptothecin 39.6153 µM -0.490731543984756 0.330236426594874 no 2272 0.311808166513089 773 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2335 9018011 154.17 µM -0.491210565609341 0.330076217891822 no 2273 0.311638763441727 735 6458208
SGTC_1763 st044482 94.5 µM -0.493150207505807 0.329427823718956 no 2274 0.310953228666719 769 88505
SGTC_2841 9004761 38.96 µM -0.493837267505975 0.329198272348423 no 2275 0.310710555622007 732 2991039
SGTC_1432 4049-0298 68.4 µM -0.495349488143403 0.328693256137142 no 2276 0.310176721818867 773 741646
SGTC_2593 nobiletin 86.24 µM -0.497654866173406 0.327923961608124 no 2277 0.309363662524004 738 72344 An anti-infammatory.
SGTC_1907 st060210 83.7 µM -0.498576873144339 0.327616495973797 no 2278 0.309038750479128 760 688793
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.499842319567684 0.327194692390442 no 2279 0.308593054727103 762 688803
SGTC_672 1441-0018 53.7 µM -0.501455139947527 0.326657420527872 no 2280 0.308025420909 738 251141
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.501596753064361 0.326610262707116 no 2281 0.307975601923882 747 5379071
SGTC_2136 5328288 199.296 µM -0.502402833749297 0.326341886906979 no 2282 0.307692093058709 745 262395
SGTC_1419 3993-2473 62.6 µM -0.502578363621286 0.326283458057276 no 2283 0.307630372177548 764 704026
SGTC_696 1560-0013 611 µM -0.502719376495809 0.326236522012037 no 2284 0.30758079231681 755 1650269
SGTC_1740 st038286 13.222 µM -0.503801577377253 0.325876403789096 no 2285 0.307200409569247 728 716786
SGTC_2260 7964312 200 µM -0.510169914624441 0.323760544645882 no 2286 0.30496621376362 762 231951
SGTC_1635 st007035 42.4 µM -0.510607455551113 0.323615381007909 no 2287 0.304812977121955 770 3716403
SGTC_983 1491-0821 12.2 µM -0.511175240054278 0.323427046262929 no 2288 0.304614177295127 745 46495113
SGTC_2670 beta-carotene 100 µM -0.511311059852268 0.323382001388505 no 2289 0.304566630914001 746 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_106 0092-0003 11.579 µM -0.511745941512169 0.323237789539244 no 2290 0.304414414283733 767 1072148
SGTC_1412 3909-8563 178 µM -0.512372238118302 0.323030148922053 no 2291 0.304195258401067 770 23767530
SGTC_184 1494-0393 24.714 µM -0.512495516903238 0.322989283912912 no 2292 0.304152128541193 773 3090647
SGTC_431 k089-0097 107 µM -0.512886399682097 0.322859726451611 no 2293 0.30401539375677 775 5499420
SGTC_920 mycophenolic acid 780.421 nM -0.514057697477658 0.322471630461845 no 2294 0.303605826024331 757 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1429 4049-0205 9.46 µM -0.514540583702128 0.322311687961376 no 2295 0.303437046930557 755 22774478
SGTC_1162 k048-0130 20.1 µM -0.514688504743246 0.322262699850137 no 2296 0.303385353741816 778 6797406
SGTC_642 0335-0876 158 µM -0.515041114906007 0.322145935771453 no 2297 0.303262144795005 773 6812350
SGTC_710 3448-4187 58 µM -0.515297397808989 0.322061080719606 no 2298 0.303172608532799 747 3946412
SGTC_1272 0839-0021 27 µM -0.515714051147663 0.321923146951335 no 2299 0.303027069700533 763 5027250
SGTC_2806 7952793 58.44 µM -0.515795214796071 0.321896280447229 no 2300 0.302998722521701 764 2972490
SGTC_2840 9008771 71.43 µM -0.516374211877867 0.321704649895846 no 2301 0.302796536701131 727 2992978
SGTC_343 4130-2827 29.8 µM -0.517574076941334 0.321307681798876 no 2302 0.302377736201421 745 1118244
SGTC_562 3772-2733 112 µM -0.51805067296252 0.321150059484462 no 2303 0.302211457409615 767 2876874 YIL048W NEO1
SGTC_32 0928-0142 34.1 µM -0.519790451674625 0.320574944442384 no 2304 0.301604817547675 777 2244242
SGTC_2227 7312221 64.1025 µM -0.520215255354325 0.320434583309006 no 2305 0.301456776866387 769 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3354 9151612 71.43 µM -0.521274630095472 0.320084662846725 no 2306 0.301087735799122 765 27261949
SGTC_2601 securinine 100 µM -0.521843931724637 0.319896683754167 no 2307 0.300889499487346 786 442872 A GABA receptor antagonist.
SGTC_2697 mebhydrolin 72.4 µM -0.523667287494247 0.319294936862989 no 2308 0.300254985986919 757 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2381 9035592 200 µM -0.523687167984237 0.319288378489565 no 2309 0.300248071066922 772 4749657
SGTC_1553 gossypol 38.6 µM -0.524225200072795 0.319110908600517 no 2310 0.30006095771014 762 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1617 st002906 78 µM -0.525866389751426 0.318569818366531 no 2311 0.299490521406071 760 5150859
SGTC_2228 7354201 200 µM -0.526119873765864 0.318486280677576 no 2312 0.299402460574884 779 753451
SGTC_2996 9066192 71.4286 µM -0.527803902814998 0.317931529844592 no 2313 0.298817724021139 765 6472854
SGTC_1979 st071809 45.3 µM -0.529256413753734 0.317453373337689 no 2314 0.298313793522516 800 4976333
SGTC_2337 9009472 200 µM -0.52984793193549 0.317258736849892 no 2315 0.298108684608537 772 5742383
SGTC_317 4495-0002 170 µM -0.530840352122742 0.316932298823989 no 2316 0.297764707339686 767 15991618
SGTC_3147 9097027 49.47 µM -0.531203311382239 0.316812945739351 no 2317 0.297638949271791 765 25236841
SGTC_2777 climbazole 1.536 µM -0.531295309124045 0.316782696847856 no 2318 0.297607077759382 777 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2416 tofa 880 nM -0.532909385124351 0.316252187480825 no 2319 0.297048154114793 772 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_216 k038-0035 28.382 µM -0.533755128406837 0.315974362114968 no 2320 0.296755481197458 760 4444231 YPR107C YTH1
SGTC_580 1123-0028 41 µM -0.533877487291049 0.315934176010116 no 2321 0.296713149339685 777 1677248 YPR107C YTH1
SGTC_3318 9139014 38.6185 µM -0.535630073792076 0.315358816119718 no 2322 0.296107119909928 785 16643984
SGTC_3059 1327-0034 3 µM -0.535962747770083 0.315249652447105 no 2323 0.295992148265015 751 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1381 2324-0066 62.1 µM -0.535982296509512 0.315243238223425 no 2324 0.295985392886534 794 10885928
SGTC_195 4234-0266 16.654 µM -0.536156159931762 0.31518619357464 no 2325 0.295925314724286 767 2303354
SGTC_2872 9044037 25.97 µM -0.537984245073131 0.314586665172855 no 2326 0.295293962760916 774 6465195
SGTC_2646 retinol 96.75 µM -0.539576070966308 0.314065016821064 no 2327 0.294744711306443 781 445354 A vitamin A analog and teratogen.
SGTC_3006 9075424 71.4286 µM -0.539843475366944 0.313977423617651 no 2328 0.294652491007656 774 7465181
SGTC_2425 5628681 7.85 µM -0.541953678931883 0.313286555837529 no 2329 0.293925208207306 790 5714958
SGTC_1583 clindamycin 39.6 µM -0.547293845952396 0.31154114683526 no 2330 0.292088435552834 789 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_781 4335-2806 94.4 µM -0.547684083837578 0.311413764633083 no 2331 0.291954421335452 805 845254
SGTC_2814 7977482 42.97 µM -0.548625469643945 0.311106568596786 no 2332 0.291631251606114 785 6456762
SGTC_1482 3346-2049 8.48 µM -0.549374008293425 0.310862396933051 no 2333 0.291374403744301 767 3826804
SGTC_2171 5739187 198.077 µM -0.552110354748933 0.30997051583297 no 2334 0.290436373986357 751 2262761
SGTC_2534 helenine 20.12 µM -0.552144831237806 0.30995928572778 no 2335 0.290424564340571 772 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2973 9094665 17.96 µM -0.552153233602898 0.309956548833146 no 2336 0.290421686211616 796 25237061 YIL048W NEO1
SGTC_341 1486-1430 230 µM -0.552626206006435 0.309802504952967 no 2337 0.290259696746598 794 2054753 YPL210C SRP72
SGTC_3043 9092303 49.47 µM -0.554012919409751 0.309351054423291 no 2338 0.289785002022982 767 25236084
SGTC_1723 st034307 2.5525 µM -0.555083289883918 0.309002787336155 no 2339 0.289418845925393 784 867466
SGTC_738 1315-0003 72.4 µM -0.556986849227372 0.308383849203732 no 2340 0.288768207148171 800 6251474
SGTC_1950 st077106 7.18 µM -0.559900897968883 0.307437407298128 no 2341 0.287773518117202 746 13831864
SGTC_1253 0550-0034 176 µM -0.562884481935539 0.306469707939427 no 2342 0.286756773890218 767 5969915
SGTC_2643 anethole 100 µM -0.56300614252192 0.306430276952855 no 2343 0.286715350618454 811 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.56335555999621 0.306317040942349 no 2344 0.286596395943664 787 1241132 A phosphatase inhibitor.
SGTC_708 3448-5400 146 µM -0.56366777964698 0.306215875308356 no 2345 0.286490124595449 799 3462195
SGTC_3255 9139072 49.47 µM -0.563748082403579 0.306189857940188 no 2346 0.286462794674705 779 17646060
SGTC_1472 k841-0093 193 µM -0.563799107248911 0.306173326858785 no 2347 0.286445429724631 796 X1472
SGTC_294 k038-0071 157 µM -0.564713356407578 0.305877194396413 no 2348 0.286134374013296 777 24152826
SGTC_1958 st076513 41.9 µM -0.565878952381904 0.305499832718039 no 2349 0.28573803523022 789 732122 YGL099W LSG1
SGTC_3041 9091929 49.47 µM -0.566195548999459 0.305397370220129 no 2350 0.285630427676932 795 25236887
SGTC_3243 9134147 49.47 µM -0.568034268748466 0.304802593330172 no 2351 0.285005849483651 799 24282180
SGTC_661 1304-0007 33.6 µM -0.568738584795199 0.304574902295425 no 2352 0.284766779321778 774 3117130
SGTC_2818 7996756 12.99 µM -0.569778975282987 0.304238703749639 no 2353 0.28441380862283 799 2241621
SGTC_146 3448-8650 53.125 µM -0.570119031786282 0.304128851534704 no 2354 0.284298483843014 813 2891488 YIL048W NEO1
SGTC_591 4299-0174 154 µM -0.570912322856349 0.303872654678595 no 2355 0.284029538658545 791 5509088
SGTC_1165 k072-0275 30.3 µM -0.571171078267767 0.303789109299952 no 2356 0.283941840543049 777 6153523 YGL055W OLE1
SGTC_1369 1866-0067 208 µM -0.571690606708045 0.303621398059668 no 2357 0.283765799633285 783 3531355
SGTC_2431 5490079 200 µM -0.571934306813577 0.303542742411389 no 2358 0.283683240474219 827 5722345
SGTC_471 1-acyl-paf 4 µM -0.572798428774001 0.303263915313748 no 2359 0.283390591534374 769 16759367
SGTC_1781 st038725 66.3 µM -0.573878917024787 0.30291543427709 no 2360 0.283024870398467 767 4270275 YIL048W NEO1
SGTC_3157 9099274 49.47 µM -0.574064735831818 0.302855521725568 no 2361 0.282961997721541 787 17217662
SGTC_328 k915-0120 63.5 µM -0.57432203169374 0.302772571974801 no 2362 0.282874951515601 775 6624543
SGTC_2140 5586273 200 µM -0.575105145317736 0.302520166192092 no 2363 0.282610094161565 789 854421
SGTC_1956 st077085 54 µM -0.575200025496343 0.302489591717102 no 2364 0.282578012773979 807 24208685
SGTC_2832 7992762 51.95 µM -0.577836377998064 0.301640600224606 no 2365 0.281687296209284 753 2985177
SGTC_1063 disulfiram 1.84 µM -0.578215872612997 0.301518478866716 no 2366 0.28155919191018 797 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_27 0485-0001 32.618 µM -0.578497262175224 0.301427942078158 no 2367 0.281464222641018 790 2054479
SGTC_1388 3346-4487 254 µM -0.578893545791483 0.301300459006313 no 2368 0.281330502724837 811 3345614
SGTC_337 1315-0038 354 µM -0.581477263272043 0.300469881896225 no 2369 0.280459418862328 793 1626437
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.581559880203094 0.300443340439634 no 2370 0.280431586646907 797 5282362
SGTC_1322 1348-1070 12 µM -0.582811818657763 0.300041273275281 no 2371 0.280009993966832 787 6758089
SGTC_1163 k060-0048 49.9 µM -0.584740004634104 0.299422502016798 no 2372 0.279361275298129 785 6809982
SGTC_3245 9134821 49.47 µM -0.58610239311827 0.298985649132171 no 2373 0.278903354104673 810 17014901
SGTC_2455 5377712 9.75 µM -0.586971864529446 0.298707002599429 no 2374 0.27861130148277 766 2243908
SGTC_2188 6126565 140.678 µM -0.588111738413155 0.298341876950918 no 2375 0.278228647303905 782 874518
SGTC_744 1594-0068 283 µM -0.588371430486428 0.298258720526293 no 2376 0.278141504867523 804 668392
SGTC_321 4534-3890 65.3 µM -0.588918517039275 0.298083571590288 no 2377 0.277957967730636 793 699746
SGTC_1780 st038448 24.544 µM -0.589756027546644 0.297815534686875 no 2378 0.277677113425672 810 728868 YDL195W SEC31
SGTC_129 0088-0017 176.636 µM -0.593050779280348 0.296762150609518 no 2379 0.276573584676993 805 182446
SGTC_1426 4048-4480 71.7 µM -0.593153676804724 0.296729280132644 no 2380 0.276539155308891 786 14224343
SGTC_806 3966-4455 5.86 µM -0.593551015065303 0.296602366605395 no 2381 0.276406226206816 803 714982
SGTC_2849 9019321 12.99 µM -0.593581939045492 0.296592490242171 no 2382 0.276395881935957 775 16489627
SGTC_2176 5809774 33.9695 µM -0.593836673588911 0.296511139989226 no 2383 0.27631067881266 778 2870539
SGTC_2180 6301957 200 µM -0.594028171042961 0.296449991426468 no 2384 0.276246635595831 799 845462
SGTC_643 k048-0106 28.4 µM -0.595095375603767 0.296109319825255 no 2385 0.275889859809944 799 6763920
SGTC_750 4073-0104 132 µM -0.595258542455021 0.296057249759938 no 2386 0.275835331666362 785 22330957
SGTC_1702 st027038 51 µM -0.595739703591464 0.295903725326195 no 2387 0.275674564993842 786 5521182
SGTC_2583 asiatic acid 100 µM -0.596079025932274 0.295795479487126 no 2388 0.275561217531188 813 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2009 4012297 12.05 µM -0.596221501824339 0.295750034255873 no 2389 0.275513631621399 798 45595307
SGTC_1127 asiatic acid 681.4 nM -0.597107082065927 0.295467634584394 no 2390 0.275217944942196 801 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_488 nitrendipine 139 µM -0.597701775318908 0.295278064509102 no 2391 0.27501947033609 796 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1983 st071813 46.9 µM -0.598682286688295 0.294965629677893 no 2392 0.274692385743898 802 11838595
SGTC_3073 9114972 49.47 µM -0.604766587493008 0.293030313069255 no 2393 0.272667048658082 779 41905075
SGTC_3066 9117245 49.47 µM -0.6052128733574 0.292888589020177 no 2394 0.272518781632823 799 17176980
SGTC_1182 1222-0449 220 µM -0.609587397011167 0.291501087850657 no 2395 0.271067581145413 806 658318
SGTC_1689 st020265 53.493 µM -0.610874417124495 0.291093458242391 no 2396 0.270641361258717 806 5758320 YPR016C TIF6
SGTC_3050 9093513 49.47 µM -0.611114615009181 0.291017411400449 no 2397 0.270561852481636 813 25236664
SGTC_808 0711-0032 135 µM -0.611210122310039 0.290987176291948 no 2398 0.270530241504454 803 4252555
SGTC_934 2950-0684 338 µM -0.612524223252799 0.290571315475892 no 2399 0.270095488214666 809 1121253
SGTC_2553 4-methylesculetin 85.09 µM -0.612961519721432 0.290432990184548 no 2400 0.269950891884305 802 5319502
SGTC_1899 st063254 59.6 µM -0.614844347185926 0.289837767988259 no 2401 0.269328759525648 802 3093813
SGTC_537 1334-0398 209 µM -0.617341684277828 0.289049163590654 no 2402 0.268504688861676 799 5846986
SGTC_1018 4259-0013 28.1 µM -0.617357400823657 0.289044203846762 no 2403 0.268499506736334 801 6801262
SGTC_2915 7971052 15.16 µM -0.620599145862358 0.28802204791985 no 2404 0.267431700900604 791 5741558
SGTC_1629 st005085 44.9 µM -0.621547272130498 0.287723416652635 no 2405 0.26711980073145 818 24207091
SGTC_3156 9099931 49.47 µM -0.624613412341234 0.286758677589969 no 2406 0.266112407353449 818 18111053
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.624718035392453 0.28672578576856 no 2407 0.266078066979826 815 688662
SGTC_2753 fluvastatin 17.09 µM -0.625187199150374 0.28657831015253 no 2408 0.265924101188144 822 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_463 ikarugamyin 104 µM -0.625560721326832 0.286460923973672 no 2409 0.265801554443551 828 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_880 0833-0487 87.2 µM -0.627149412206536 0.285961903865082 no 2410 0.265280649967289 819 76075
SGTC_851 0394-0702 453 µM -0.628130815129864 0.285653844214383 no 2411 0.264959123942407 822 762646
SGTC_416 estradiol valerate 100 µM -0.628425428927593 0.285561396588131 no 2412 0.264862641591091 812 13791 A steroid.
SGTC_1281 0884-0031 11.8 µM -0.628856139258146 0.285426268511701 no 2413 0.264721621464542 819 1548255
SGTC_1057 3448-5381 134 µM -0.633206378913153 0.284063164159795 no 2414 0.263299440329173 793 5497911
SGTC_2460 5552655 174.22 µM -0.633218403685875 0.284059400636427 no 2415 0.263295514602727 807 5401989
SGTC_530 4358-1714 28 µM -0.634011181923261 0.283811328884136 no 2416 0.263036762329332 804 1564641
SGTC_700 3453-2283 142 µM -0.634124430716627 0.283775900170461 no 2417 0.262999810040679 813 565664
SGTC_1359 1582-0056 520 nM -0.634876118652542 0.283540796065362 no 2418 0.262754606801965 825 3661189
SGTC_2581 avocatin a 64 µM -0.635663610290589 0.28329459385509 no 2419 0.262497849752922 826 6710728 A skin care supplement.
SGTC_561 1550-0330 72.9 µM -0.636176599952378 0.283134267396365 no 2420 0.262330661579885 810 6812934
SGTC_933 2914-0560 114 µM -0.6363758669784 0.283072001516324 no 2421 0.262265733284845 789 463887
SGTC_1389 3405-0187 19 µM -0.636403289403726 0.283063433219975 no 2422 0.262256798726297 800 799890
SGTC_963 1269-2853 151 µM -0.636904034900585 0.282906994269364 no 2423 0.262093677197323 790 3668223
SGTC_2018 5133068 143 µM -0.6373184636837 0.282777553111237 no 2424 0.261958713310665 832 785362
SGTC_3129 9127257 49.47 µM -0.637606044378596 0.282687747942157 no 2425 0.261865080028325 822 837894
SGTC_503 tyrphostin 8 294 µM -0.638155913166917 0.282516074096569 no 2426 0.261686096269149 838 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.638514044325214 0.282404289379286 no 2427 0.261569557386456 827 442882
SGTC_1421 4029-0249 71.4 µM -0.641506757233063 0.281470996201242 no 2428 0.2605967460428 820 2894095
SGTC_2782 7736369 71.43 µM -0.641561464649872 0.281453949266668 no 2429 0.260578980198581 814 2950836 YOL077C BRX1
SGTC_1605 st000082 49.1 µM -0.644720080619693 0.280470564178049 no 2430 0.259554300429109 809 1114022
SGTC_181 1447-1644 8.07 µM -0.646581910611183 0.279891693037618 no 2431 0.258951284309983 826 534600
SGTC_2986 9022445 71.43 µM -0.647540637836044 0.27959383639642 no 2432 0.258641051226985 829 6459286
SGTC_285 1486-1325 46 µM -0.650014241263931 0.278826050597446 no 2433 0.257841511292537 815 22310230
SGTC_3134 9127454 49.47 µM -0.652147265060794 0.278164802805433 no 2434 0.257153087821409 826 24262820
SGTC_2937 9044753 11.33 µM -0.653779833711597 0.277659215776965 no 2435 0.256626830331499 807 6465530 YGL099W LSG1
SGTC_1089 terbinafine 2.25 µM -0.654766944442993 0.277353737281508 no 2436 0.2563089080889 830 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1809 st050081 57.6 µM -0.654946874430742 0.277298072546138 no 2437 0.256250979530569 821 5036894
SGTC_2173 5763948 167 µM -0.655689290185226 0.277068450028078 no 2438 0.256012030573242 814 2867177
SGTC_585 0kpi-0023 191 µM -0.656980080689437 0.276669441815269 no 2439 0.255596862297707 801 64601
SGTC_443 clozapine 122 µM -0.657911288598803 0.276381762464235 no 2440 0.255297568227389 831 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.658391926503161 0.27623333575915 no 2441 0.255143160932819 829 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2919 7978188 46.38 µM -0.65930930189845 0.275950147943285 no 2442 0.25484858519544 800 2980291
SGTC_1244 0416-0015 52.5 µM -0.660482472889301 0.275588205595312 no 2443 0.25447213123618 809 96201
SGTC_2699 st077704 54.6 µM -0.661805785922374 0.275180222350656 no 2444 0.254047848785611 815 645852
SGTC_2585 alliin 100 µM -0.662727964944182 0.274896086427543 no 2445 0.253752398048908 834 87310 A garlic compound which reacts with lipids.
SGTC_2810 7959871 45.46 µM -0.66345013933869 0.274673675649107 no 2446 0.253521151474607 819 2974535
SGTC_2984 9022109 38.96 µM -0.663737921422596 0.274585071047094 no 2447 0.253429031989376 848 6459207
SGTC_3270 9137563 49.47 µM -0.664031582208666 0.274494671001163 no 2448 0.25333504885964 805 17015724
SGTC_3078 9116413 49.47 µM -0.664491755118169 0.274353041685012 no 2449 0.253187812087075 823 17177322
SGTC_202 3594-0513 34.79 µM -0.664998241711664 0.274197199929982 no 2450 0.253025808843225 822 708429
SGTC_763 3453-1109 128 µM -0.664999251278584 0.274196889338219 no 2451 0.253025485980728 817 1560353
SGTC_1437 4092-1038 11.6 µM -0.665242488393407 0.274122062866018 no 2452 0.252947704347356 829 3977136
SGTC_2300 7976697 71.57 µM -0.665252370266413 0.274119023141486 no 2453 0.252944544617722 807 2236109
SGTC_1449 4112-4002 201 µM -0.667727974985946 0.273358037062228 no 2454 0.252153624695868 824 2059539
SGTC_2556 citropten 84.59 µM -0.668738498362136 0.273047709178581 no 2455 0.251831152382085 787 2775 A potential DNA crosslinker.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.670102773143438 0.272629022805817 no 2456 0.251396138605503 826 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1720 st037298 9.481 µM -0.670350518447901 0.27255302570878 no 2457 0.251317184968459 841 597396
SGTC_2506 ethyl hematommate 54.16 µM -0.670912389558246 0.272380707951782 no 2458 0.251138171567527 821 3940691 An allergen.
SGTC_2 0422-0095 29 µM -0.671444445088436 0.272217584103132 no 2459 0.250968719670986 795 6790840
SGTC_250 brefeldin a 552.239 µM -0.671729351351692 0.272130254150926 no 2460 0.250878006078374 822 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2971 9092186 9.93 µM -0.673996358439803 0.271435863990381 no 2461 0.250156814426447 804 25236400
SGTC_3203 9113543 49.47 µM -0.674259571867893 0.271355298265475 no 2462 0.250073150957895 822 17018012
SGTC_1087 pterostilbene 9.05 µM -0.675974608087322 0.270830643078998 no 2463 0.249528383328268 843 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2771 fluoxetine 41.05 µM -0.676127882982581 0.270783778658886 no 2464 0.249479727488719 831 3386 A selective serotonin reuptake inhibitor.
SGTC_913 3487-1245 167 µM -0.676307390348803 0.270728898701787 no 2465 0.249422750780048 817 4016153
SGTC_2892 9047358 58.44 µM -0.677731943119076 0.270293573773915 no 2466 0.248970834561957 829 6466771
SGTC_2850 9015429 58.44 µM -0.678132460506604 0.270171243892751 no 2467 0.248843855448982 848 6457570
SGTC_3057 9095946 49.47 µM -0.678963693859121 0.269917448991174 no 2468 0.24858043319597 838 24540043
SGTC_2369 9071472 200 µM -0.680039663957982 0.269589107567666 no 2469 0.248239673295128 833 17296037
SGTC_2430 5571206 200 µM -0.680194759370841 0.269541795391571 no 2470 0.248190575101237 836 1731771
SGTC_734 2023-0417 80 µM -0.680609811407981 0.26941520338035 no 2471 0.248059208521864 838 3935732
SGTC_1590 st077108 57.8 µM -0.681663529074117 0.26909395054398 no 2472 0.247725866957035 800 5489485
SGTC_1919 st067113 52.3 µM -0.682510401028341 0.268835899326389 no 2473 0.247458134109858 840 1268243
SGTC_536 3852-0578 10.6 µM -0.686953048437848 0.267484214965136 no 2474 0.246056158033233 840 2869208
SGTC_778 3456-2434 196 µM -0.687467442028999 0.267327931357007 no 2475 0.245894105394264 799 5539063
SGTC_2518 prenyletin 46.28 µM -0.687521203122856 0.26731160026372 no 2476 0.24587717200637 808 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2543 pimpinellin 60.67 µM -0.687804338389408 0.267225600119185 no 2477 0.245788001870931 828 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2888 9058547 12.99 µM -0.688176661417095 0.267112531141158 no 2478 0.245670769524648 819 16476514
SGTC_1498 4478-3555 97.6 µM -0.689926613634294 0.266581420371635 no 2479 0.24512016925509 816 3437919
SGTC_1795 st049545 62.3 µM -0.690011857629869 0.266555562452107 no 2480 0.245093365275354 801 5291882
SGTC_2745 rifampicin 24.3 µM -0.690371862798247 0.266446372451072 no 2481 0.244980183240557 802 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1575 cyproterone acetate 48 µM -0.691911286339238 0.265979718825084 no 2482 0.244496521210174 846 9880 An androgen receptor antagonist and liver toxin.
SGTC_3332 9141069 11.198 µM -0.691966386936971 0.265963023566771 no 2483 0.244479219032786 834 17332883
SGTC_406 estrone 100 µM -0.692068338200315 0.26593213414623 no 2484 0.24444720698452 829 5870 A steroid.
SGTC_1279 0874-0590 65.2 µM -0.69337470150832 0.265536490219982 no 2485 0.244037217163464 836 3523074
SGTC_3307 9126885 69.2785 µM -0.694320021215858 0.265250377936602 no 2486 0.243740768947485 824 24824909
SGTC_3104 9120930 49.47 µM -0.694484849293635 0.265200506782497 no 2487 0.243689099478098 836 17014836
SGTC_586 0957-0265 8.15 µM -0.694765410692704 0.265115629764384 no 2488 0.243601164116084 829 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2871 9038510 12.99 µM -0.695035849975573 0.265033828007671 no 2489 0.24351641751564 855 4945164
SGTC_971 1315-0384 26.7 µM -0.695344260789723 0.264940556375416 no 2490 0.243419791350558 852 6769120
SGTC_999 SEC7.066 22.7 µM -0.695398905038308 0.264924032241152 no 2491 0.243402673280814 833 740511 YDR170C SEC7
SGTC_3294 9122953 26.2835 µM -0.695479876235335 0.264899547938802 no 2492 0.243377309124902 834 16459826
SGTC_833 3852-0053 558 µM -0.695869424912742 0.264781771172654 no 2493 0.243255303312603 849 3123681
SGTC_2146 5545642 200 µM -0.696315407015407 0.264646964930836 no 2494 0.243115663273899 830 825326
SGTC_549 1661-1316 519 µM -0.69737894617421 0.264325631726281 no 2495 0.242782836916929 842 2857282
SGTC_2328 6201408 200 µM -0.698297729370762 0.264048194486046 no 2496 0.242495509480736 861 2890418
SGTC_631 k072-0230 41.5 µM -0.698694000244227 0.263928581715625 no 2497 0.242371642131573 843 5773147
SGTC_1682 st012968 530 nM -0.698794009765549 0.263898398608941 no 2498 0.242340386321882 822 24207270
SGTC_492 tmb-8 126 µM -0.699381539306877 0.263721116363612 no 2499 0.24215681080315 824 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_626 0214-0009 33 µM -0.699452422087597 0.263699732169875 no 2500 0.242134668345034 848 3437874
SGTC_9 0092-0002 10.449 µM -0.701259862528091 0.263154755462473 no 2501 0.241570428715355 844 759368
SGTC_1314 1222-0010 41.1 µM -0.701783772725501 0.262996894490755 no 2502 0.241407010063994 844 3526027
SGTC_2050 5263056 171 µM -0.702356438837603 0.262824398113677 no 2503 0.241228452133592 828 763468 YGL055W OLE1
SGTC_2413 inermin 26.06 µM -0.702890359823813 0.262663624536698 no 2504 0.241062039657473 847 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2121 5257820 149.641 µM -0.703424418537528 0.262502859841297 no 2505 0.240895646719487 812 791256
SGTC_557 1315-0110 16.2 µM -0.706313563671394 0.261634030841995 no 2506 0.239996580149728 828 6833801
SGTC_3210 9128157 49.47 µM -0.708135831355894 0.261086795141631 no 2507 0.239430455096314 847 17590849
SGTC_1570 verbenone 133 µM -0.708396037729371 0.261008701956731 no 2508 0.23934967616272 842 29025 A natural terpanoid with antifungal properties.
SGTC_3216 9129716 49.47 µM -0.708650516500996 0.260932339358665 no 2509 0.239270689716669 819 8056934
SGTC_113 0099-0221 2.5 µM -0.709601652345897 0.260647029473436 no 2510 0.238975597341684 837 89219
SGTC_2881 9058953 51.95 µM -0.710395926640902 0.260408896054069 no 2511 0.238729324219088 799 17122249
SGTC_2756 carbadox 75.1 µM -0.712117270695797 0.2598932003209 no 2512 0.2381960802097 832 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1653 st012112 65 µM -0.712325005309965 0.259831000960066 no 2513 0.238131771610184 848 720429
SGTC_2979 9012552 45.46 µM -0.714725436641311 0.259112827549891 no 2514 0.237389358418682 856 17100905
SGTC_1327 1436-0082 2.18 µM -0.717726729270525 0.258216331340094 no 2515 0.236462899472302 848 15992205
SGTC_3226 9131256 49.47 µM -0.718215535964302 0.258070475541952 no 2516 0.236312200047256 807 17178073
SGTC_1101 ebselen 5.29 µM -0.719240192200708 0.257764865469062 no 2517 0.235996469538118 843 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2703 st077852 53.4 µM -0.719442938639069 0.257704417356847 no 2518 0.235934024208471 854 6281836
SGTC_3053 9095903 49.47 µM -0.720427230328444 0.257411058996156 no 2519 0.235630994614737 879 17174018
SGTC_211 3455-0679 143.504 µM -0.720541125803119 0.257377124785227 no 2520 0.235595943974486 814 748649
SGTC_2279 7948423 32.93 µM -0.721709012794188 0.257029296728649 no 2521 0.235236699853113 818 1247112
SGTC_715 0868-0130 184 µM -0.723569305935683 0.256475756902625 no 2522 0.23466509549078 855 2876258
SGTC_2889 9059656 51.95 µM -0.724275298592614 0.256265847836415 no 2523 0.234448369347598 866 3949838
SGTC_2445 5742597 35.57 µM -0.724323611919284 0.256251486365072 no 2524 0.234433542136899 850 1774255
SGTC_2907 7721985 69.9 µM -0.726562168931781 0.255586520162614 no 2525 0.233747105157824 832 3267881
SGTC_749 1000-0129 128 µM -0.728027840509457 0.255151629309633 no 2526 0.233298271994908 859 708470
SGTC_1141 3253-0389 52.6 µM -0.730009399685116 0.254564281286014 no 2527 0.232692219509336 855 5402031
SGTC_3336 9143619 71.43 µM -0.730034710807179 0.254556783476013 no 2528 0.232684483861205 858 45595730
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.731514743066513 0.254118560821623 no 2529 0.232232401337892 869 5393153
SGTC_233 rapamycin 362 pM -0.73189124692973 0.254007144984783 no 2530 0.232117474568726 855 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2301 7769476 200 µM -0.731988557454248 0.253978352812861 no 2531 0.232087775947975 849 977820
SGTC_1501 4491-0275 38.4 µM -0.732349124919437 0.253871683286509 no 2532 0.231977751241941 851 5104718
SGTC_1895 st058434 18.3 µM -0.732363806742184 0.253867340345009 no 2533 0.231973271799198 876 5393175
SGTC_1408 3909-7976 48.8 µM -0.734569609933752 0.253215298295485 no 2534 0.231300825908858 854 24152374
SGTC_2063 5246145 200 µM -0.735143537393407 0.253045788110534 no 2535 0.231126040780776 849 711240
SGTC_282 k297-0036 65.7 µM -0.735913858974973 0.252818366553257 no 2536 0.23089156125157 857 5061378
SGTC_3166 9102297 49.47 µM -0.736878723583789 0.252533662048191 no 2537 0.230598051903265 843 25237072
SGTC_1905 st060207 84.5 µM -0.738088671273974 0.252176879269684 no 2538 0.230230283741884 837 1948547
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.739776976585962 0.251679485634207 no 2539 0.229717665661836 857 61125 An anti-inflammatory.
SGTC_306 1672-3436 11.6 µM -0.741139002143858 0.251278595598682 no 2540 0.229304581783997 864 6797378
SGTC_3060 1327-0027 12.5 µM -0.74152350092379 0.251165485787124 no 2541 0.229188043939283 832 16000455 YPR107C YTH1
SGTC_94 0334-0113 514.748 µM -0.741650612513466 0.251128098697602 no 2542 0.229149524957826 850 6795178
SGTC_2139 5578692 56.4705 µM -0.741868847669407 0.251063916473643 no 2543 0.229083401015452 841 650991 YMR113W FOL3
SGTC_2887 9044784 58.44 µM -0.743169711830801 0.250681516820571 no 2544 0.228689469113411 841 6465546
SGTC_1922 5578187 25 µM -0.744685460685279 0.250236339470702 no 2545 0.228230945319047 815 1350412
SGTC_1200 1643-0193 18.4 µM -0.745112336551579 0.250111041191477 no 2546 0.22810190595073 863 5403974
SGTC_987 1497-1013 404 µM -0.745871319783223 0.249888343673658 no 2547 0.227872575929315 848 1676435
SGTC_1275 0867-0008 21.1 µM -0.74621028112101 0.249788921139862 no 2548 0.227770199236267 852 3422836
SGTC_978 1416-0512 87.4 µM -0.74691323335515 0.249582801481435 no 2549 0.227557968688605 870 6814003
SGTC_1106 tegaserod maleate 11.7 µM -0.748526763260552 0.249110024175773 no 2550 0.227071244133969 852 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_189 3970-0742 2.116 µM -0.749511213607799 0.248821806435926 no 2551 0.226774571232843 842 2891807
SGTC_111 0083-0039 52.457 µM -0.749645477123707 0.248782511839145 no 2552 0.226734126677834 828 759313
SGTC_1901 st060216 58.6 µM -0.749671084174898 0.248775017857097 no 2553 0.22672641346008 851 688792
SGTC_816 0325-0417 81.3 µM -0.749745827241609 0.248753144756876 no 2554 0.226703900603776 844 68101
SGTC_1428 4049-0204 61.7 µM -0.750944469866909 0.248402509276941 no 2555 0.226343037897986 862 X1428
SGTC_1752 st044819 83.042 µM -0.751705710525139 0.248179962586867 no 2556 0.226114027752037 846 441209 YML126C ERG13
SGTC_1832 st054113 55 µM -0.752128893693879 0.248056292110909 no 2557 0.225986774812291 851 1251267
SGTC_1912 st060209 90.8 µM -0.752750390575857 0.247874726319485 no 2558 0.225799961526509 864 688787
SGTC_19 0279-0214 38.434 µM -0.752970306494007 0.24781049647989 no 2559 0.225733878799491 854 3566274 YBR002C RER2
SGTC_1178 0988-0033 191 µM -0.755834805725018 0.246974687480945 no 2560 0.224874122878173 851 5392207
SGTC_2885 9057732 51.95 µM -0.760085098614359 0.245737313851033 no 2561 0.22360185963247 850 6471414
SGTC_2194 5927483 104.545 µM -0.76093024089873 0.245491667723644 no 2562 0.223349367398062 821 760979
SGTC_1810 st050138 53 µM -0.761657213541084 0.245280473970065 no 2563 0.223132309043172 880 3444541
SGTC_1277 0873-0036 22 µM -0.762381650252384 0.245070114133043 no 2564 0.222916127387381 864 5965735
SGTC_219 mitoxanthrone 164.414 µM -0.763392255129928 0.244776819798967 no 2565 0.222614748716478 878 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_477 mead ethanolamide 10 µM -0.764706531071478 0.244395677901953 no 2566 0.222223158127761 813 16061185
SGTC_2787 5284540 71.43 µM -0.765584688829226 0.244141189243237 no 2567 0.221961728847729 864 736958
SGTC_675 1309-0189 238 µM -0.765603923105619 0.244135616781603 no 2568 0.221956004732099 839 4246530
SGTC_2809 7964133 12.99 µM -0.766364376711152 0.243915356808545 no 2569 0.221729761492365 877 1253665
SGTC_3277 9138724 49.47 µM -0.766970261366868 0.243739943408678 no 2570 0.221549598545401 830 15943418
SGTC_1202 1988-0068 29.6 µM -0.767109553495399 0.243699625716169 no 2571 0.221508191140444 852 2850480
SGTC_548 1436-0017 110 µM -0.767375182425954 0.243622750193064 no 2572 0.221429239827002 854 9677137
SGTC_3003 9075612 71.4286 µM -0.767998418407156 0.243442431228885 no 2573 0.221244062261648 874 6501993
SGTC_174 3553-0389 74.3 µM -0.768750140476096 0.243225033749841 no 2574 0.221020826462754 852 738071
SGTC_421 streptovitacin 30 mM -0.769898146673467 0.242893233809413 no 2575 0.220680156689665 893 91467 include heat shock
SGTC_1364 1653-0028 37.6 µM -0.771723894905249 0.242366055836408 no 2576 0.220138987606858 841 5718652
SGTC_2405 ticlatone 3.52 µM -0.772803763923849 0.242054539725901 no 2577 0.219819262760823 883 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1708 st033234 31.827 µM -0.77396328339143 0.241720288278475 no 2578 0.219476252159911 836 674664
SGTC_931 2812-0076 566 µM -0.775006765672426 0.241419700853493 no 2579 0.219167830871449 868 3450959
SGTC_380 3970-0968 6 µM -0.775500604292299 0.241277515610647 no 2580 0.219021954264263 850 2891601
SGTC_1993 st073995 70.8 µM -0.776384433196314 0.241023158618141 no 2581 0.218761016597521 864 3098394
SGTC_2773 thioridazine 9.09 µM -0.778689793236305 0.240360386141776 no 2582 0.21808123501744 869 5452 An antipsychotic.
SGTC_2131 toluylene red 5.2905 µM -0.779499504244791 0.240127836548146 no 2583 0.21784276475314 840 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_360 0957-0399 1.01 µM -0.779653998450498 0.240083479636012 no 2584 0.217797281322271 869 6752301 YPR165W RHO1
SGTC_1944 st076371 56.9 µM -0.780953668292615 0.239710507653248 no 2585 0.217414872616647 857 24208455
SGTC_3341 9147222 25.867 µM -0.781168079249131 0.239649007594211 no 2586 0.217351822623556 861 1939759
SGTC_1316 1272-0050 65.9 µM -0.781508363323508 0.239551420699079 no 2587 0.217251779879169 868 7340392
SGTC_2153 5569715 200 µM -0.782031583893258 0.239401413485933 no 2588 0.217098006119192 857 2054701
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.782666906045891 0.239219335763842 no 2589 0.216911370438135 880 91467 include heat shock
SGTC_2491 paeonol 100 µM -0.782673018829471 0.23921758426161 no 2590 0.216909575164274 874 11092 Increases levels of cortical cytochrome oxidase.
SGTC_48 0382-0018 55 µM -0.783222579833128 0.239060146613014 no 2591 0.21674820875422 853 762596
SGTC_1274 0865-0114 173 µM -0.783512989930619 0.238976973118323 no 2592 0.216662964307275 846 870624
SGTC_3160 9100216 49.47 µM -0.783899747806225 0.23886623017663 no 2593 0.216549468887592 851 17191039
SGTC_1555 citronellol 128 µM -0.783987594184275 0.238841080454039 no 2594 0.21652369486233 853 8842 A terpine precursor.
SGTC_3283 9109332 35.8195 µM -0.784552951163928 0.238679257886119 no 2595 0.216357862255766 843 17027281
SGTC_1221 2958-7315 257 µM -0.785587818301361 0.238383202541053 no 2596 0.21605450170852 870 4562705
SGTC_2807 7945238 51.95 µM -0.785962920662393 0.238275942733443 no 2597 0.215944605215486 873 17148797
SGTC_56 0957-0365 83.25 µM -0.787258943476361 0.237905551019405 no 2598 0.215565149256114 873 6752360
SGTC_93 0109-0045 59.227 µM -0.788151018560215 0.237650787497125 no 2599 0.215304187938122 880 88733
SGTC_2200 6600604 21.907 µM -0.791221443620167 0.236775064597026 no 2600 0.214407390124154 904 2904777
SGTC_725 1497-0963 19 µM -0.791799559852221 0.236610377507122 no 2601 0.21423877951537 857 3549977
SGTC_2656 pseudo-anisatin 100 µM -0.793629297747587 0.236089558479918 no 2602 0.213705635630202 897 6708809 A neurotoxin.
SGTC_1022 4477-0945 21.3 µM -0.795159882324207 0.235654376439878 no 2603 0.213260252416452 846 4648966
SGTC_2952 9073731 13.78 µM -0.795895285493785 0.235445441079557 no 2604 0.213046450862032 877 16457353
SGTC_3117 9124945 49.47 µM -0.796934469664243 0.235150372887375 no 2605 0.21274454527145 856 17592065
SGTC_3007 9078383 71.4286 µM -0.79783314884946 0.234895364745572 no 2606 0.212483660949459 870 6496995
SGTC_2690 usnic acid 100 µM -0.797954237455708 0.234861016473363 no 2607 0.212448523522608 879 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2486 5283202 22.39 µM -0.798495989970545 0.234707375709048 no 2608 0.212291359643214 864 1377751
SGTC_1423 4048-0112 5.59 µM -0.79971174647513 0.234362790099123 no 2609 0.211938912822388 855 X1423
SGTC_1240 0356-0016 42.1 µM -0.799715160981862 0.234361822709388 no 2610 0.211937923441895 829 4305613
SGTC_3027 9089541 49.47 µM -0.79974263013319 0.23435404029671 no 2611 0.211929964135031 886 9943819
SGTC_2627 acetyl isogambogic acid 100 µM -0.800694574470751 0.234084428908648 no 2612 0.211654242135062 885 6857789 A caspase activator and apoptosis inducer.
SGTC_1390 3413-2614 145 µM -0.801109939323192 0.233966842377578 no 2613 0.211534001317099 892 3421432
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.801320123414256 0.233907353380921 no 2614 0.211473171962784 890 368090
SGTC_1943 st076331 65.2 µM -0.804414768912764 0.233032437881036 no 2615 0.210578737265635 878 24208415
SGTC_3044 9093193 49.47 µM -0.805448377948912 0.232740622192747 no 2616 0.210280492083352 857 25236277
SGTC_1138 3761-0006 1.03 µM -0.805590944587663 0.232700387731626 no 2617 0.210239374327877 865 12061087
SGTC_299 1273-0059 1.44 µM -0.807341576500054 0.232206648241445 no 2618 0.209734858303596 861 2848077
SGTC_1150 3909-7983 10.9 µM -0.808583882485119 0.231856628403268 no 2619 0.20937726934898 874 23965914
SGTC_690 glyoxal 20.3 µM -0.809010701599171 0.231736439936906 no 2620 0.20925449535261 871 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1960 st011366 51.8 µM -0.809674657003316 0.231549545019374 no 2621 0.2090635936482 879 3972846
SGTC_88 0180-0332 8.668 µM -0.810826177442577 0.231225606125011 no 2622 0.20873274962089 869 3101745
SGTC_3026 9090633 49.47 µM -0.811551451746607 0.23102170610531 no 2623 0.208524529093369 867 25236842
SGTC_1816 st051957 91.6 µM -0.811924722825193 0.230916805657661 no 2624 0.208417413666204 896 674121
SGTC_2163 5671233 125 µM -0.812483211936499 0.230759903023805 no 2625 0.208257207913731 863 701023
SGTC_1581 himbacine 57.9 µM -0.812799401648783 0.230671098695323 no 2626 0.208166539331278 897 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2985 9022375 71.43 µM -0.814221620444954 0.230271893712239 no 2627 0.207759000904887 893 4939335
SGTC_2366 9070441 60.58 µM -0.815025859703418 0.230046321574262 no 2628 0.207528753973245 876 6837235
SGTC_1082 camptothecin 424.86 nM -0.815475486431225 0.229920264674584 no 2629 0.207400095373985 867 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2142 5622915 118.518 µM -0.818000294286045 0.229213130675821 no 2630 0.206678509617828 882 5322196
SGTC_2941 9056145 11.23 µM -0.818689309765786 0.22902036712659 no 2631 0.206481848685434 863 2119517
SGTC_1459 k035-0031 35.7 µM -0.81917944473665 0.228883299088818 no 2632 0.206342020347829 859 3877128 YMR208W ERG12
SGTC_966 1300-0360 30.2 µM -0.819331584002064 0.228840762152062 no 2633 0.206298628656065 856 70588
SGTC_1973 st070275 50.2 µM -0.819608516654383 0.228763345360691 no 2634 0.206219658482746 849 17118334
SGTC_3300 9124615 50.48 µM -0.820416310884602 0.22853760971642 no 2635 0.205989410102802 884 24824903
SGTC_2412 st077135 33.4 µM -0.821755659567706 0.22816360865483 no 2636 0.20560798707733 905 13258915
SGTC_450 aminopyrene 156 nM -0.821995696876451 0.228096616779936 no 2637 0.205539672989099 866 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_491 tetrandrine 80.3 µM -0.824677150338274 0.227349003855462 no 2638 0.204777453772555 876 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1382 3002-2117 298 µM -0.825378292550684 0.227153747143613 no 2639 0.204578427502386 913 1497314
SGTC_2397 5161689 200 µM -0.827841194362965 0.226468618739714 no 2640 0.203880220876212 884 2259942
SGTC_1878 temozolomide 1 mM -0.827886204227321 0.226456108791653 no 2641 0.203867474283621 861 5394 DNA alkylating agent.
SGTC_1271 0832-2808 169 µM -0.828295749846708 0.226342298464231 no 2642 0.203751514616755 879 3663794
SGTC_2243 6634756 200 µM -0.829473196402396 0.226015272992549 no 2643 0.203418348854481 862 885676
SGTC_324 1315-0088 19.6 µM -0.829773829610859 0.225931817576269 no 2644 0.203333334950097 906 6787421
SGTC_3188 9110789 49.47 µM -0.830813166853777 0.225643433090151 no 2645 0.20303959162892 900 849217
SGTC_3271 9137798 49.47 µM -0.833235472546728 0.224972125924071 no 2646 0.202355970206425 836 6498326
SGTC_720 r052-1644 49.9 µM -0.834445994523164 0.224637071818172 no 2647 0.202014854001958 879 1422863 YOR257W CDC31
SGTC_3084 9116877 49.47 µM -0.834785136558225 0.224543253235191 no 2648 0.201919348018806 861 27241325
SGTC_2357 9067248 200 µM -0.835369687828659 0.224381598043066 no 2649 0.201754795659352 910 9150235
SGTC_1159 4092-0538 61.2 µM -0.83552739321115 0.224337996601136 no 2650 0.20171041503618 908 717301
SGTC_1741 st038134 10.228 µM -0.835612247572624 0.224314538564473 no 2651 0.201686538185545 890 1272587
SGTC_390 dec-rvkr-cmk 16.7 µM -0.837696745558913 0.223738715344304 no 2652 0.201100520850899 881 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2056 5235370 200 µM -0.838904396843945 0.223405497706826 no 2653 0.200761480140316 889 5511916
SGTC_1104 tacrolimus 29.8 µM -0.838951874847234 0.223392403249277 no 2654 0.200748157994182 871 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3293 9120939 62.045 µM -0.839956205222414 0.223115510763844 no 2655 0.200466471081123 878 934087
SGTC_2376 9072922 81.32 µM -0.840517508978164 0.222960845265048 no 2656 0.200309144357053 900 17087968
SGTC_49 0717-0965 32.132 µM -0.841383637267068 0.222722306181008 no 2657 0.200066524568548 895 5889349 YGL099W LSG1
SGTC_1821 st053465 65.6 µM -0.842713786802381 0.222356255067553 no 2658 0.199694267345144 886 675086
SGTC_207 4185-0010 4.486 µM -0.842824192579826 0.222325887331562 no 2659 0.199663387795343 870 3761753
SGTC_3136 9095672 49.47 µM -0.843853333486523 0.222042930124928 no 2660 0.199375684138393 846 17217380
SGTC_366 0181-0206 4.31 µM -0.843966999946873 0.22201169070574 no 2661 0.199343923184975 898 274874
SGTC_2079 5212404 121 µM -0.847006513369022 0.221177259981284 no 2662 0.198495745496386 862 758462
SGTC_3261 9137475 49.47 µM -0.848180528915845 0.220855441133095 no 2663 0.198168719618513 825 17027690
SGTC_351 caspofungin 25 nM -0.850939387566528 0.220100244373321 no 2664 0.1974015118433 865 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2740 felodipine 17.08 µM -0.852208045708971 0.219753465759432 no 2665 0.197049315930559 848 3333 L-type calcium channel blocker
SGTC_747 3448-8087 38.7 µM -0.852645501350075 0.219633963158848 no 2666 0.196927960816857 914 5168703
SGTC_1058 3448-5425 97.3 µM -0.857132363230664 0.218410414175793 no 2667 0.195685868584232 882 7279705
SGTC_352 k048-0007 5.11 µM -0.857825593664083 0.218221723815568 no 2668 0.195494387539245 915 6811911
SGTC_1134 3477-0009 42.5 µM -0.859010034055362 0.217899548489452 no 2669 0.195167490067974 863 3973534
SGTC_76 0433-0009 400.328 µM -0.859674495719297 0.21771893085349 no 2670 0.194984248727798 943 2841569
SGTC_2701 st077767 14.721 µM -0.859926142733716 0.21765054933034 no 2671 0.194914878308568 880 5721188
SGTC_2688 kanamycin b 96.69 µM -0.860849780748865 0.21739966998569 no 2672 0.194660391762201 871 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_994 3910-0338 138 µM -0.861967211503593 0.217096375795364 no 2673 0.194352780603113 876 3479481
SGTC_1758 st042942 75.2445 µM -0.862151965064707 0.217046253359169 no 2674 0.194301949372857 884 669317
SGTC_1787 fluconazole 80 µM -0.86261406713595 0.216920917364824 no 2675 0.194174846722388 853 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_856 0433-0016 11.3 µM -0.863523591557185 0.216674349204809 no 2676 0.193924827099888 881 3911780
SGTC_3169 9102970 49.47 µM -0.864075301026059 0.21652486216095 no 2677 0.193773263050313 908 17027839
SGTC_2145 5634607 200 µM -0.864511553723127 0.216406700673376 no 2678 0.193653468097297 906 308662
SGTC_397 arbidol 50 µM -0.864734048698979 0.216346451035691 no 2679 0.193592388389708 888 131410 A RNA synthesis inhibitor.
SGTC_3146 9095609 49.47 µM -0.866226405006515 0.215942585422197 no 2680 0.193183007908199 903 17173999
SGTC_1487 3970-0795 2.82 µM -0.867450302350638 0.215611697180347 no 2681 0.192847665314857 880 3765103
SGTC_1213 1315-0166 115 µM -0.867694126875434 0.215545812843843 no 2682 0.192780900948643 881 768401
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.872499594688177 0.214249701876213 no 2683 0.191467944590183 898 16486 A toxic proline analog.
SGTC_1347 1493-0251 600 nM -0.873118148376001 0.214083198118517 no 2684 0.191299341429636 850 3986378
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.875262546469297 0.213506547316996 no 2685 0.19071553397783 904 4213774
SGTC_716 1683-5115 658 µM -0.875521171453847 0.213437061607769 no 2686 0.19064519788426 894 723597
SGTC_1489 4065-0444 182 µM -0.875999251373073 0.213308648857437 no 2687 0.19051522037833 868 2877968
SGTC_2493 resveratrol 26.09 µM -0.881763253727776 0.211763980980785 no 2688 0.188952423463009 863 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_926 2268-1401 59.4 µM -0.882785909457029 0.211490609580261 no 2689 0.188675977486858 900 2931578
SGTC_1545 lovastatin 49.4 µM -0.884616339549493 0.211001824104504 no 2690 0.188181795502413 884 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2103 5378138 10 µM -0.885949016078671 0.210646372285515 no 2691 0.187822500649779 887 244142
SGTC_3315 9136395 68.55 µM -0.888166471754549 0.21005571120129 no 2692 0.187225605524589 914 16876844
SGTC_2218 6965428 192.983 µM -0.888500890253296 0.209966717054558 no 2693 0.187135688589535 883 675684
SGTC_17 0960-0276 49.807 µM -0.888876891694396 0.20986668348286 no 2694 0.187034622923011 898 6821114
SGTC_1290 0986-0249 10.2 µM -0.893661744064677 0.208596142414599 no 2695 0.185751449888121 896 53329
SGTC_3080 9117754 49.47 µM -0.893904220469823 0.208531877631005 no 2696 0.185686569728901 887 9550191
SGTC_2379 9035213 200 µM -0.894369734283035 0.208408532806688 no 2697 0.185562050174375 877 646551
SGTC_1813 st051246 8.6015 µM -0.894705121647097 0.208319693599305 no 2698 0.18547237006169 876 5291959
SGTC_3171 9103192 49.47 µM -0.894712532182541 0.208317730909143 no 2699 0.185470388842871 902 13018434
SGTC_220 paclitaxel 373.376 µM -0.895419320846237 0.208130587131923 no 2700 0.185281488109343 888 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_45 0kpi-0036 14.9 µM -0.895687304884664 0.208059656164201 no 2701 0.185209896275231 895 2795021
SGTC_393 acivicin 6.25 µM -0.896570506116019 0.207825988350124 no 2702 0.184974071035175 880 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2143 5623677 140.463 µM -0.896750450777981 0.207778399553222 no 2703 0.184926046557629 868 5375313
SGTC_2361 9034121 116 µM -0.896855155069452 0.207750712051197 no 2704 0.184898106150135 925 6496917
SGTC_2799 7812892 81.82 µM -0.898821045653786 0.2072312660629 no 2705 0.184373994123085 908 20205235
SGTC_1333 1482-0047 286 µM -0.903056106095017 0.206114851910219 no 2706 0.183248059161849 925 3811116
SGTC_2879 9041815 71.43 µM -0.903070176089518 0.206111148839652 no 2707 0.183244325668207 879 4942971
SGTC_229 benomyl 22.8748 µM -0.903698339567536 0.205945863195679 no 2708 0.183077689908127 901 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_961 1252-1571 372 µM -0.905617921695521 0.205441260212596 no 2709 0.182569059788489 912 6813498
SGTC_981 1488-1094 54.9 µM -0.905710145125285 0.205417035821625 no 2710 0.182544645659705 894 3449522
SGTC_3019 9081971 49.47 µM -0.910329372358572 0.204205871894593 no 2711 0.181324416355667 912 16451803
SGTC_2474 5321570 43.32 µM -0.91503725811769 0.202975848176716 no 2712 0.180086035432346 914 2841384
SGTC_637 1181-0519 7.26 µM -0.915254807586425 0.202919116446057 no 2713 0.180028939001771 903 6252091 YGR060W ERG25
SGTC_281 1672-3440 14.9 µM -0.915619613266136 0.202824005054788 no 2714 0.17993322030478 908 6833000
SGTC_2420 aureobasidin a 50 nM -0.919225366923731 0.201885353677868 no 2715 0.178988852744377 904 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2278 7948257 134.34 µM -0.9210969865407 0.201399159858215 no 2716 0.178499896703653 904 1247028
SGTC_1872 amphotericin b 148 nM -0.921467658394135 0.201302953119772 no 2717 0.178403159497579 894 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1343 1487-0095 224 µM -0.923599399745012 0.200750201242016 no 2718 0.177847463241591 917 4560101 YGL055W OLE1
SGTC_2727 riluzole 51.77 µM -0.926988683521487 0.19987325168869 no 2719 0.176966204944793 921 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_546 peri-Naphthalide 147 µM -0.927376051143986 0.199773170389104 no 2720 0.176865660278867 883 223824 A penicillin ester.
SGTC_182 3448-4371 550.524 µM -0.928158042798919 0.199571224880414 no 2721 0.176662797520028 886 3491403
SGTC_433 pimozide 108 µM -0.932628093970706 0.198419216283355 no 2722 0.175506011392244 909 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1914 st062367 72.6 µM -0.932913293087215 0.198345852015874 no 2723 0.175432369174366 914 978205
SGTC_2448 5185112 27.17 µM -0.933173239967274 0.198278997864354 no 2724 0.17536526448683 898 5718189
SGTC_2220 6782180 200 µM -0.934147035847667 0.198028674177237 no 2725 0.175114026021681 890 833803
SGTC_1798 st045719 60.953 µM -0.934809168072651 0.197858575713 no 2726 0.174943326969955 882 3980186
SGTC_508 roscovitine 141 µM -0.937233453474658 0.197236542504851 no 2727 0.174319242598614 931 160355 A CDKinase inhibitor.
SGTC_1668 st014914 51.6 µM -0.938948333069766 0.196797246844083 no 2728 0.173878636031023 912 2839556
SGTC_2845 9003024 42.97 µM -0.941603273382193 0.196118308439822 no 2729 0.173197896609544 898 2990173
SGTC_3238 9133470 49.47 µM -0.94220006305039 0.195965889323796 no 2730 0.173045110827101 890 3534688
SGTC_1260 0700-1617 7.75 µM -0.943410839476771 0.195656879867313 no 2731 0.172735400476425 898 2853078
SGTC_1350 1495-0454 146 µM -0.947256005780402 0.194677495263975 no 2732 0.171754171450283 900 1069057
SGTC_2484 5809818 12.04 µM -0.947609333543585 0.194587650652629 no 2733 0.171664186425226 912 2870548
SGTC_2067 5224629 34.075 µM -0.948043403897633 0.19447730926397 no 2734 0.171553679224869 919 2835000
SGTC_2910 7948405 25.97 µM -0.948907681089537 0.194257722036817 no 2735 0.171333783803124 872 2971328
SGTC_578 3460-0051 92 µM -0.950883120014176 0.193756388797338 no 2736 0.17083185579069 940 2876744
SGTC_2862 9027634 71.43 µM -0.951973355354179 0.193480043469545 no 2737 0.170555247476711 902 5012562
SGTC_1857 st056007 79.3 µM -0.952793800394226 0.193272241356083 no 2738 0.170347278035993 907 619834
SGTC_2513 baicalein 25.65 µM -0.953781505355019 0.193022256461796 no 2739 0.170097126514811 938 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_606 k015-0008 38.6 µM -0.953836517190639 0.193008338953263 no 2740 0.170083200843315 943 1970475
SGTC_2483 5729050 27.16 µM -0.954392404187286 0.192867738836602 no 2741 0.169942524854588 907 2865180
SGTC_3237 9133362 49.47 µM -0.954673556948269 0.192796650891446 no 2742 0.169871403117474 924 43845137
SGTC_3148 9097893 49.47 µM -0.958369822236516 0.191863559584383 no 2743 0.16893815345666 887 17174100
SGTC_904 1141-0088 396 µM -0.959548131311184 0.191566687390982 no 2744 0.168641342328391 947 1378119
SGTC_3035 9091303 49.47 µM -0.960228958311714 0.191395282969905 no 2745 0.168469997735392 927 25237002
SGTC_2428 5615643 7.78 µM -0.961918489207457 0.190970334296495 no 2746 0.168045275114397 912 2253075
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.963071430638894 0.190680680404661 no 2747 0.167755838909093 949 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1380 2291-0730 164 µM -0.963472689868794 0.190579935189688 no 2748 0.167655181515049 937 2999191
SGTC_3191 9110352 49.47 µM -0.963557614672919 0.190558617085289 no 2749 0.167633882795623 906 17122424
SGTC_1469 k284-2957 126 µM -0.96787922196058 0.189475726483961 no 2750 0.166552346233173 889 23884841
SGTC_2233 sulbentine 40.3845 µM -0.970015261490722 0.188941887723754 no 2751 0.166019442506177 895 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_798 1287-0182 476 µM -0.973313119673098 0.188119509207643 no 2752 0.165198851932407 951 1649755
SGTC_2111 5486399 200 µM -0.974783851027904 0.18775347004154 no 2753 0.164833744621595 896 689674
SGTC_2033 5192550 145 µM -0.975424034612246 0.187594277121419 no 2754 0.164674983196854 884 182073
SGTC_1252 0493-0875 34.8 µM -0.976517291597666 0.187322612411391 no 2755 0.164404091614241 911 3960963
SGTC_3193 9111931 49.47 µM -0.977477033022786 0.187084325727285 no 2756 0.164166521300666 946 17087244
SGTC_3154 9100113 49.47 µM -0.977975141243346 0.186960728277128 no 2757 0.164043309518698 922 25237525
SGTC_1172 0370-0043 85 µM -0.978016189795122 0.186950545000647 no 2758 0.164033158447246 934 376585
SGTC_1531 st059297 52.4 µM -0.978356328102675 0.186866177093241 no 2759 0.163949059873332 918 7566702
SGTC_1457 k015-0032 57.3 µM -0.97948906439357 0.186585383104351 no 2760 0.16366919465535 929 4302660
SGTC_1782 st039423 80.636 µM -0.979994156413954 0.186460260116623 no 2761 0.163544501584317 937 2068169
SGTC_563 tetrahydrosecaminediol 614 µM -0.984689317431274 0.185299648292044 no 2762 0.162388350799828 931 334274 A psychoactive constituent of the cannabis plant.
SGTC_670 4204-0025 119 µM -0.987120556949992 0.184700429088735 no 2763 0.161791770599745 932 719039
SGTC_1923 st058458 19.1 µM -0.989138054327932 0.18420409921818 no 2764 0.161297800592658 953 3534982
SGTC_1565 sinapyl alcohol 95.1 µM -0.989227349082555 0.184182150779141 no 2765 0.16127596015903 921 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1229 0139-0193 12.2 µM -0.989612878582222 0.184087407227778 no 2766 0.161181686379327 919 3090752
SGTC_2182 6325192 200 µM -0.98988305294751 0.184021030188042 no 2767 0.161115641896529 892 736248
SGTC_2344 7990960 76.95 µM -0.991711398566109 0.183572229893235 no 2768 0.160669164535273 906 140813
SGTC_879 0831-1030 162 µM -0.991879679369721 0.183530956654334 no 2769 0.160628111437134 929 1549252
SGTC_1631 benzylvanillin 81.9 µM -0.993155407239578 0.183218254559855 no 2770 0.16031711293312 904 75506
SGTC_2151 5563267 85.4165 µM -0.993508284611991 0.183131817156045 no 2771 0.160231157581149 956 5310824
SGTC_3323 9138564 53.9225 µM -0.995800662745907 0.182570918089468 no 2772 0.159673504111364 928 43912313 YNL103W MET4
SGTC_1014 4130-3005 69.3 µM -0.996312506628738 0.18244582680729 no 2773 0.159549164481882 938 743608
SGTC_179 1273-0063 6.77 µM -0.996520038042611 0.182395122752267 no 2774 0.159498767993724 951 3108139
SGTC_287 k060-0039 29.6 µM -0.997025461881233 0.182271674481892 no 2775 0.159376075537192 924 5861974
SGTC_2186 6124449 200 µM -0.999652371224355 0.181630900924434 no 2776 0.158739384538732 915 3834182 YLR033W RSC58
SGTC_2298 7976326 193.81 µM -1.00099865685715 0.181303052811412 no 2777 0.158413728868747 920 2235818
SGTC_1463 k081-0032 34.1 µM -1.0023020570292 0.180986001474635 no 2778 0.158098864681534 886 977755
SGTC_912 3474-0017 2.18 µM -1.00530418016735 0.180257059432867 no 2779 0.157375201439213 943 3360550
SGTC_2125 5246583 200 µM -1.00647128058838 0.179974175206411 no 2780 0.157094460004778 926 835267
SGTC_3215 9129942 49.47 µM -1.00696800022615 0.179853863885542 no 2781 0.156975076026397 950 17682944
SGTC_881 0833-0569 170 µM -1.00737394022541 0.179755577978911 no 2782 0.156877554791424 932 5418700
SGTC_3175 9106517 49.47 µM -1.00949056124469 0.179243650012536 no 2783 0.156369713030361 943 41468073
SGTC_3322 9139058 2.11 µM -1.01031261504811 0.179045074752579 no 2784 0.156172769565789 918 4908926 YPR165W RHO1
SGTC_1817 st052116 64.4 µM -1.0106311693429 0.178968162024077 no 2785 0.156096495904814 944 4361398
SGTC_895 0964-0006 13.7 µM -1.01150334393188 0.178757687917713 no 2786 0.155887790734148 948 6738897
SGTC_3202 9113761 49.47 µM -1.01203427252277 0.178629639996266 no 2787 0.155760833417803 931 4798415
SGTC_2658 polymyxin b sulfate 77.05 µM -1.01248368421356 0.17852129725057 no 2788 0.155653421974915 935 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1735 st034310 56.75 µM -1.01399106411241 0.178158205199345 no 2789 0.155293508110447 908 871153
SGTC_2135 5326629 150.42 µM -1.01481718139539 0.177959410755196 no 2790 0.155096491043741 939 5020077
SGTC_2037 5169046 200 µM -1.01496535449286 0.177923769615008 no 2791 0.155061171357519 931 5718022
SGTC_1341 1486-1360 280 µM -1.01512544843365 0.177885266128508 no 2792 0.155023016096331 957 3976547
SGTC_1361 1608-0041 5.61 µM -1.01594161465205 0.17768905529262 no 2793 0.154828595210421 928 X1361
SGTC_52 0329-0193 875 nM -1.01600441766426 0.177673962764197 no 2794 0.154813641433281 931 3739292
SGTC_1263 0774-1208 64.8 µM -1.01746989400938 0.177322015962999 no 2795 0.154464973542553 942 906585
SGTC_187 1488-2104 32.728 µM -1.02022422398114 0.176661731965619 no 2796 0.15381106578267 924 2852859
SGTC_1313 1220-0047 237 µM -1.02202180540589 0.176231644793996 no 2797 0.15338529005174 929 3528706
SGTC_1321 1326-2144 215 µM -1.02307621547121 0.175979676517024 no 2798 0.153135905786886 942 3513030
SGTC_1540 guanosine 70.6 µM -1.02329452755757 0.17592753584399 no 2799 0.153084305205348 911 6802 Guanosine is a purine nucleoside
SGTC_517 1365-0151 113 µM -1.02357992951476 0.175859386485515 no 2800 0.153016864542031 942 768657
SGTC_2295 7971645 200 µM -1.02494002168392 0.175534848276201 no 2801 0.152695744514865 965 2978226 YKL099C UTP11
SGTC_2563 tomatine 8.54 µM -1.02807364244414 0.174788565606919 no 2802 0.151957593996666 936 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3109 9122853 49.47 µM -1.02819392512624 0.174759960061918 no 2803 0.151929307725055 963 1234709
SGTC_942 3253-1115 227 µM -1.03445591788087 0.173274843103697 no 2804 0.150461537361638 943 46497897
SGTC_159 3970-0959 50 µM -1.03559619526105 0.173005278176563 no 2805 0.150195283870418 907 6615653
SGTC_1346 1488-2224 62.4 µM -1.03644310513226 0.172805239195214 no 2806 0.149997734725038 914 3722427
SGTC_545 4218-0007 221 µM -1.0376595786143 0.172518167837214 no 2807 0.149714284908927 952 2840508
SGTC_2878 9043973 25.97 µM -1.03960024390432 0.172060826959299 no 2808 0.149262831778386 958 6465167
SGTC_544 k015-0020 52.4 µM -1.04037495609429 0.171878473141704 no 2809 0.149082866135942 930 3008304
SGTC_2674 ligustilide 100 µM -1.04088656830713 0.171758116181766 no 2810 0.14896409811136 940 5319022 A signalling regulator.
SGTC_684 1140-0066 328 µM -1.04090195922914 0.171754496295989 no 2811 0.148960526171277 931 6813534
SGTC_1515 3460-0031 42.1 µM -1.04181024680118 0.171540956840135 no 2812 0.148749831244873 931 2876596
SGTC_2666 tannic acid 100 µM -1.04187826155455 0.171524973323474 no 2813 0.148734061923224 921 16134267 A thiamine antagonist.
SGTC_25 0118-0223 35.662 µM -1.04440487115494 0.170931892620197 no 2814 0.1481490554394 939 5333628
SGTC_605 1315-0399 119 µM -1.04533786741435 0.17071321894304 no 2815 0.147933420998099 940 24020461
SGTC_58 0957-0393 9 µM -1.05137934462292 0.169301566797782 no 2816 0.146542199291072 942 6997992
SGTC_1021 4476-0760 85.3 µM -1.05238031931175 0.169068404600527 no 2817 0.14631254723268 955 746768
SGTC_776 4476-4378 112 µM -1.05323533419252 0.16886940496249 no 2818 0.146116573980145 971 2892008
SGTC_1497 4476-2978 41.3 µM -1.05667718285738 0.168069858028199 no 2819 0.145329470932265 919 1528379
SGTC_2225 6654152 15.4 µM -1.05760668048573 0.167854352704263 no 2820 0.145117397796586 913 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1422 4031-0024 15.5 µM -1.0579397536804 0.167777172533112 no 2821 0.145041454903764 957 782427
SGTC_2934 9036370 36.88 µM -1.05808506930336 0.167743506960946 no 2822 0.145008330362938 918 6462800
SGTC_2780 5215298 71.43 µM -1.05908165256372 0.167512743668897 no 2823 0.144781297496125 960 2834131
SGTC_1688 st021091 57.6 µM -1.05954821150987 0.167404780186616 no 2824 0.14467509243376 982 3656366
SGTC_3330 9141424 71.43 µM -1.06217409703292 0.166797977035919 no 2825 0.144078328407854 927 27261020
SGTC_3325 9138760 55.175 µM -1.06284592981295 0.166642954717902 no 2826 0.143925913390842 920 43844959
SGTC_2423 st077119 87.2 µM -1.06354193357473 0.166482453150387 no 2827 0.143768129571143 925 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_639 0833-0042 114 µM -1.06489868880494 0.166169866334147 no 2828 0.143460889230612 970 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1050 3232-1156 69.3 µM -1.06636517129693 0.16583242578116 no 2829 0.143129299742093 944 700529
SGTC_758 0868-0029 16 µM -1.06679751609443 0.165733026982524 no 2830 0.143031640236237 918 762687
SGTC_137 0438-0332 85.389 µM -1.06684693437694 0.165721667860998 no 2831 0.143020480335264 953 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2048 5246248 200 µM -1.06735605971852 0.165604671316186 no 2832 0.142905541180116 927 677046
SGTC_2113 5491891 107.031 µM -1.06796525104139 0.165464749913018 no 2833 0.142768093380086 940 789979
SGTC_1972 st070201 17.4 µM -1.06802068544072 0.1654520213245 no 2834 0.14275559052151 943 2829099
SGTC_218 alverine citrate 93.75 µM -1.06907262782574 0.1652105992792 no 2835 0.142518472234166 936 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1208 2323-2347 50.3 µM -1.0691012570884 0.165204032017507 no 2836 0.142512022638857 941 5412760
SGTC_1174 0739-0097 51.1 µM -1.07081419884648 0.164811408094647 no 2837 0.142126490633523 958 728447
SGTC_1062 mesoridazine 14.2 µM -1.07160280496327 0.164630854785882 no 2838 0.141949236475922 924 4078 A neuroleptic.
SGTC_2645 abamectin 100 µM -1.07267549425384 0.164385465755708 no 2839 0.14170836959349 892 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2576 guaiol 23.12 µM -1.07302710263828 0.164305083242186 no 2840 0.141629478011868 915 227829
SGTC_1398 3558-0053 112 µM -1.07363394479587 0.164166410738185 no 2841 0.14149338875338 932 4532369
SGTC_1840 st055363 71 µM -1.07467446057296 0.163928814044591 no 2842 0.141260250962283 972 676033
SGTC_1896 st058441 89 µM -1.0802146640351 0.16266749468901 no 2843 0.140023299930645 934 688759
SGTC_2741 miltefosine 3.04 µM -1.08041101986168 0.162622907170015 no 2844 0.139979595389903 921 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3340 9146634 11.102 µM -1.08074103429966 0.16254798702132 no 2845 0.139906162230443 930 4907387
SGTC_112 phenothiazine 287.218 µM -1.08154091258117 0.162366491195341 no 2846 0.139728285970969 952 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3083 9117465 49.47 µM -1.08160435101321 0.162352102389712 no 2847 0.139714185169335 962 16420915
SGTC_1356 1502-0781 85.8 µM -1.08177803445748 0.162312712577972 no 2848 0.139675584566057 953 567702
SGTC_24 0417-1663 219 µM -1.08211203457107 0.16223698190273 no 2849 0.139601374465147 983 4329390
SGTC_2966 9084041 48.03 µM -1.0822461748624 0.162206573613948 no 2850 0.139571577937579 958 17741380
SGTC_1656 st012921 11 µM -1.08376113029102 0.16186340571329 no 2851 0.139235361764604 929 6732821
SGTC_2544 sphondin 68.51 µM -1.08456666043315 0.161681129690314 no 2852 0.139056813952934 934 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1319 1306-0155 43.7 µM -1.08565544539766 0.161434971241253 no 2853 0.138815729784534 949 3122360
SGTC_1012 4112-3522 18 µM -1.08657184039229 0.161227977168857 no 2854 0.138613037793955 941 3112398
SGTC_1243 0416-0003 5.65 µM -1.0881646480352 0.160868608114799 no 2855 0.138261214097435 947 2141977
SGTC_1460 k062-0059 9.15 µM -1.08838928835137 0.160817966903913 no 2856 0.138211643958455 922 1373085
SGTC_2451 5856223 45.7 µM -1.08841689651549 0.160811743846837 no 2857 0.138205552653413 946 2179896
SGTC_826 1683-5028 118 µM -1.08892080130454 0.160698188102818 no 2858 0.138094406183853 947 722377
SGTC_1879 gemcitabine 100 µM -1.09223940341782 0.159951644231066 no 2859 0.137363943609554 963 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2054 5233173 129 µM -1.0950307368082 0.159325472424003 no 2860 0.136751585427874 837 6889
SGTC_2122 5258151 111.688 µM -1.09547139314643 0.15922676815212 no 2861 0.136655085784377 961 2173356
SGTC_2545 solidagenone 89.61 µM -1.09697036950564 0.158891306689587 no 2862 0.136327172530904 888 6708572 An anti ulcer agent
SGTC_2463 5473429 200 µM -1.09720896762201 0.158837952697556 no 2863 0.136275026961874 935 5399405
SGTC_3197 9113331 49.47 µM -1.09933697186436 0.158362619612492 no 2864 0.13581055574444 941 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3250 9135583 49.47 µM -1.09943137530474 0.158341554322029 no 2865 0.135789975817023 952 7699353
SGTC_449 xestospongin c 11.1929 µM -1.10153120034727 0.157873472233947 no 2866 0.135332766513649 948 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2785 7756463 72.73 µM -1.10169102520089 0.157837882159047 no 2867 0.135298010017436 953 2201551
SGTC_1273 0849-0096 14.1 µM -1.10220612333206 0.157723215074815 no 2868 0.135186035248621 972 5286025
SGTC_1811 st050069 61.5 µM -1.10487111940265 0.157130828809229 no 2869 0.134607719123192 931 3877702
SGTC_2030 5175110 200 µM -1.1055784917036 0.156973837241408 no 2870 0.134454501749544 980 2831986
SGTC_2598 perillyl alcohol 100 µM -1.10951071306955 0.156103016392072 no 2871 0.133604962733818 963 10819 An apoptosis inducer.
SGTC_1305 1181-0477 144 µM -1.11293146017348 0.155348059605565 no 2872 0.132868933610814 969 6252086
SGTC_2097 5376186 200 µM -1.11339409375718 0.155246141938818 no 2873 0.132769605250781 954 742755
SGTC_1677 st019204 53.9 µM -1.1136465960188 0.155190534591774 no 2874 0.132715414085456 956 3945625
SGTC_793 0488-0545 106 µM -1.11380347483325 0.155155992555258 no 2875 0.132681752968741 959 292548
SGTC_1783 st039459 87.517 µM -1.11544347437046 0.154795196550325 no 2876 0.132330214204494 974 729761
SGTC_2582 agaric acid 100 µM -1.11754726770109 0.154333179200717 no 2877 0.131880200562594 940 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1338 1486-1223 76 µM -1.11800256247506 0.154233311345838 no 2878 0.131782949476293 965 3444526
SGTC_3353 9151644 39.2805 µM -1.11848685522617 0.154127129771389 no 2879 0.13167955873284 950 4909158
SGTC_138 0850-0259 40.9225 µM -1.118732358416 0.154073321473978 no 2880 0.131627168106876 937 6813004
SGTC_142 0335-0849 62.6745 µM -1.11940048221017 0.153926948011181 no 2881 0.131484662674354 913 3889043 YPR107C YTH1
SGTC_773 4358-1457 44.6 µM -1.1196360673034 0.153875357662538 no 2882 0.131434439675721 981 1186886
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.1202831379062 0.153733715742597 no 2883 0.131296562655864 973 65057 A dermal irritant. YDR527W RBA50
SGTC_855 0428-0020 25 µM -1.12041202608291 0.153705512797881 no 2884 0.131269111252365 953 6812414
SGTC_3033 9090887 49.47 µM -1.12119514381958 0.153534226835682 no 2885 0.131102403184495 959 19325384
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.12670599488403 0.152332452047352 no 2886 0.129933403481818 944 3256 An antibiotic and ribosome inhibitor.
SGTC_264 promethazine 12.5 mM -1.12714165236684 0.152237713414136 no 2887 0.129841297567126 963 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_697 0508-1955 564 µM -1.13072661929869 0.151459607517174 no 2888 0.129085086897247 948 6243113
SGTC_1808 st050063 61.5 µM -1.13127515229379 0.151340783813382 no 2889 0.128969649611549 973 4011993
SGTC_2621 lithochol-11-enic acid 100 µM -1.13253012266121 0.151069164255542 no 2890 0.128705813812972 981 6708711
SGTC_2834 9001755 58.44 µM -1.13394972365375 0.150762304098296 no 2891 0.128407818949738 959 2989575
SGTC_373 0844-0104 25.9 µM -1.13765515293326 0.149963297156766 no 2892 0.127632253450858 951 5375804
SGTC_3291 9121177 71.43 µM -1.13879873924997 0.149717275278782 no 2893 0.127393553891396 964 17015612
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.13890285495626 0.149694890051713 no 2894 0.127371837361018 973 688751
SGTC_2210 7115885 190.385 µM -1.13924154082961 0.149622086896864 no 2895 0.127301211824742 987 2927039
SGTC_479 n-linoleoylglycine 10 µM -1.1400717347934 0.149443730215743 no 2896 0.127128208257511 981 6433346 An anti-infammatory.
SGTC_3268 9137683 49.47 µM -1.14240530837819 0.148943151784507 no 2897 0.126642792889733 1015 1953228
SGTC_3106 9121286 49.47 µM -1.14326892252239 0.148758180937655 no 2898 0.126463476960702 930 15943471
SGTC_1560 lithocholic acid 53.1 µM -1.14372340792069 0.14866089990381 no 2899 0.12636918126766 928 9903 A bile acid which acts as a detergent.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.14639883404106 0.148089096330604 no 2900 0.125815082463234 933 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_844 0330-0132 15.3 µM -1.14747573758508 0.147859351879911 no 2901 0.125592527515657 953 2828079
SGTC_1966 st070145 16.1 µM -1.14799950185585 0.147747699356112 no 2902 0.125484384738287 970 3748532
SGTC_2876 9059903 25.97 µM -1.14974178794877 0.147376696961838 no 2903 0.125125118758739 955 6916095
SGTC_81 0411-0046 9.971 µM -1.15071820859378 0.147169051158954 no 2904 0.12492409151548 949 12925265
SGTC_2822 7994718 71.43 µM -1.15092120962126 0.147125905560155 no 2905 0.124882325645163 1000 1018011
SGTC_1661 st013063 9.66 µM -1.15198570601295 0.146899797594031 no 2906 0.12466347357036 977 721395
SGTC_4 0960-0234 25.671 µM -1.15243833839703 0.146803725337083 no 2907 0.124570497190641 941 6821112
SGTC_1815 st051655 58.2 µM -1.15361098513974 0.146555024482114 no 2908 0.124329846324109 960 5984156
SGTC_735 3076-0345 636 µM -1.15440808591262 0.146386132849166 no 2909 0.12416645083386 953 2888990
SGTC_1790 st045711 43.5 µM -1.16057403196568 0.145084093275442 no 2910 0.122907585470974 903 585119
SGTC_468 gf-109203x 121 µM -1.16207140433242 0.14476907871096 no 2911 0.122603230902022 985 2396 A protein kinase C inhibitor.
SGTC_979 1426-2828 121 µM -1.16412810122387 0.144337145806103 no 2912 0.122186051005354 984 747872
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.1650957525839 0.144134227297503 no 2913 0.121990117985046 949 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2193 5925765 200 µM -1.16671009443593 0.143796124759008 no 2914 0.121663732444302 967 877370
SGTC_685 1278-0033 54.9 µM -1.16769470170048 0.143590174711844 no 2915 0.121464967367678 962 3590572
SGTC_2801 7907800 81.82 µM -1.16779367121837 0.143569484300565 no 2916 0.121445000782664 952 6620925
SGTC_634 1611-4317 11.2 µM -1.16785712594388 0.143556219614532 no 2917 0.121432200336157 979 2843522
SGTC_1391 3442-0225 151 µM -1.16854034288645 0.143413451162351 no 2918 0.121294438031046 969 5227075
SGTC_1637 st007924 17.4 µM -1.16968328625966 0.143174830352775 no 2919 0.121064223322337 934 683336
SGTC_3252 9135871 49.47 µM -1.17010045000063 0.143087802813173 no 2920 0.120980273708229 979 17682838
SGTC_663 1486-0733 13.9 µM -1.1720148068872 0.142688893365853 no 2921 0.120595555725036 972 722445 YPR165W RHO1
SGTC_820 1582-0060 59.9 µM -1.17513084275332 0.142041190084155 no 2922 0.119971186469461 964 3848840
SGTC_1640 st009078 66.4 µM -1.17601795610525 0.141857158068902 no 2923 0.119793850394359 970 690618
SGTC_3105 9121040 49.47 µM -1.17852064374096 0.141338845104385 no 2924 0.119294553672038 911 41448907
SGTC_523 1934-0222 13.7 µM -1.17922632791246 0.141192928416957 no 2925 0.119154032535516 988 1361595
SGTC_1187 1391-0724 117 µM -1.18788807903114 0.139410229372496 no 2926 0.11743875344456 983 6997986
SGTC_1466 k213-0079 57.5 µM -1.18887479220537 0.139208126977325 no 2927 0.117244470483446 994 3657981
SGTC_2168 5727979 200 µM -1.18947106396149 0.139086092994505 no 2928 0.117127175513089 980 695210
SGTC_1307 1187-1599 12.2 µM -1.19285180347852 0.138395562194765 no 2929 0.116463708827601 977 1538471
SGTC_1996 st072960 66.8 µM -1.19313190521384 0.13833845519162 no 2930 0.116408858971485 957 1719405
SGTC_989 1501-0895 10.3 µM -1.19424963222543 0.138110733506465 no 2931 0.116190166804349 952 2830112
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.19676850346114 0.137598485276744 no 2932 0.115698398946037 985 94937 An inhibitor of serotonin biosynthesis.
SGTC_970 1315-0089 19.5 µM -1.20040905834228 0.136860420943799 no 2933 0.114990256290731 965 6811083 YLR033W RSC58
SGTC_2040 5100729 123 µM -1.20097019695294 0.136746900189892 no 2934 0.11488138116016 985 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1994 st072947 40.9 µM -1.20378178200433 0.136179073893439 no 2935 0.114336966455003 988 5286565 YDL195W SEC31
SGTC_1155 4088-0394 48.2 µM -1.20403533549516 0.1361279457957 no 2936 0.114287960669186 967 2326248
SGTC_1173 0443-0020 122 µM -1.20420921329645 0.136092891593041 no 2937 0.114254362922474 977 5331295
SGTC_2825 7998094 58.44 µM -1.20714409950807 0.13550214336029 no 2938 0.113688327029262 978 2987815
SGTC_279 1273-0055 2.93 µM -1.20877176904129 0.13517527665104 no 2939 0.113375270158888 996 2847562
SGTC_1276 0871-0068 94.2 µM -1.21054475331513 0.134819843637366 no 2940 0.113034964432344 972 3414906
SGTC_235 0330-0087 5 mM -1.21243805901807 0.134440998131159 no 2941 0.112672369815412 985 46494818 YHR062C RPP1
SGTC_2285 7945142 200 µM -1.21268757913436 0.134391124373948 no 2942 0.112624645228629 965 2970608
SGTC_814 3342-0569 96 µM -1.21710947285046 0.13350938911957 no 2943 0.111781283497109 963 4346283
SGTC_2712 st079126 47.7 µM -1.21768962974736 0.133394000494666 no 2944 0.111670969676493 982 3152970
SGTC_161 4065-0411 162.148 µM -1.21805775505912 0.133320818863051 no 2945 0.111601012960664 979 1906281 YLR208W SEC13
SGTC_1849 st056239 19.2 µM -1.21993951764758 0.132947164555699 no 2946 0.11124390188688 964 5393181
SGTC_2721 ifenprodil 61.44 µM -1.22391406787892 0.132160324861278 no 2947 0.110492323042827 992 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2969 9091408 28.7 µM -1.22470119524895 0.132004879331572 no 2948 0.110343911817665 970 4286311
SGTC_2485 5633444 17.78 µM -1.22608872140809 0.131731171433644 no 2949 0.110082644835685 970 5724239
SGTC_10 0279-0212 42.575 µM -1.2267804222735 0.131594870651243 no 2950 0.109952565546144 996 39851 YBR002C RER2
SGTC_1298 1079-1278 263 µM -1.22917579834668 0.131123610228356 no 2951 0.109502950398074 984 2840950
SGTC_653 0203-0016 55.2 µM -1.23106782691974 0.130752202172727 no 2952 0.109148748686372 1000 295302
SGTC_726 3448-4391 34.2 µM -1.2315640001917 0.1306549230876 no 2953 0.109055997801953 984 1356692
SGTC_2629 bisabolol 100 µM -1.23211257921541 0.130547427656715 no 2954 0.10895351653412 993 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2248 tofa 1.1 µM -1.23389688625738 0.130198211265603 no 2955 0.108620664979922 942 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_529 4076-0302 30.3 µM -1.23524243710236 0.129935294103827 no 2956 0.108370144884155 989 5816522
SGTC_2112 5488546 200 µM -1.23808660208639 0.129380761773418 no 2957 0.107841975582861 1012 600757
SGTC_1204 4049-0315 18.3 µM -1.24113798839133 0.128787653068552 no 2958 0.107277389059441 976 588402
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.24132705431483 0.128750965816062 no 2959 0.107242477145752 987 1273210
SGTC_1836 st055642 81 µM -1.24175743891254 0.128667478978817 no 2960 0.107163035151912 973 8571
SGTC_2987 9018338 71.43 µM -1.24198337163671 0.128623667150558 no 2961 0.107121348637108 972 5055682
SGTC_368 fentichlor 4.58 µM -1.24265045670965 0.128494369511859 no 2962 0.10699833399342 1021 7329 A pesticide.
SGTC_3079 9117512 49.47 µM -1.24350750429222 0.128328384873807 no 2963 0.10684043867893 1028 7185044
SGTC_821 1114-0266 29.2 µM -1.24351281718058 0.128327356389777 no 2964 0.106839460401187 969 3123235
SGTC_886 0866-0150 153 µM -1.24751869076305 0.127553516436419 no 2965 0.106103685635214 987 271463
SGTC_80 0159-0065 512.242 µM -1.24781946488632 0.127495545225717 no 2966 0.106048589368065 973 1548079
SGTC_767 0929-0023 86 µM -1.24872053127477 0.127321983339039 no 2967 0.105883654372567 988 1204563
SGTC_1086 cerivastatin 2.18 µM -1.25245107374493 0.12660516160984 no 2968 0.105202772856685 961 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1257 0669-0121 16 µM -1.25571455938568 0.125980393636524 no 2969 0.104609739301032 971 4307855
SGTC_246 cycloheximide 667 µM -1.25636727668516 0.125855694606956 no 2970 0.104491420084954 985 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1703 st026983 48.3 µM -1.26300202344472 0.124593036605197 no 2971 0.103294226266105 975 1104023
SGTC_612 0302-0167 22.4 µM -1.26436793161072 0.124334193777637 no 2972 0.103048998739049 985 235821
SGTC_2092 5303694 80.6725 µM -1.26540593784388 0.12413774080123 no 2973 0.102862923875751 986 1963699
SGTC_1947 st076332 61.6 µM -1.26713294426067 0.123811369127983 no 2974 0.102553878786293 980 24208416
SGTC_2288 7946289 167.31 µM -1.26931948912856 0.123399015674414 no 2975 0.102163569053452 995 1246052
SGTC_1868 st057644 42.7 µM -1.27213914436876 0.122868687594887 no 2976 0.101661842592123 1008 688665
SGTC_872 0588-0139 234 µM -1.27333528150657 0.12264419850381 no 2977 0.101449546048317 980 2047100
SGTC_3174 9107204 49.47 µM -1.27457081789639 0.122412617286813 no 2978 0.101230595959585 1000 3938802
SGTC_2055 5235184 200 µM -1.27460379804688 0.122406439901549 no 2979 0.101224756250719 981 2836034
SGTC_507 nimesulide 162 µM -1.27643677634112 0.122063455700062 no 2980 0.100900581423918 995 4495 A COX2 inhibitor.
SGTC_1962 st076595 64.5 µM -1.27845272113606 0.121687015009058 no 2981 0.100544922470344 983 279619
SGTC_644 1498-1197 63.3 µM -1.27958837315731 0.121475312429492 no 2982 0.100344970547077 996 6741615
SGTC_2257 7960413 200 µM -1.28136759473457 0.121144159637157 no 2983 0.100032290376473 965 2974689 YIL048W NEO1
SGTC_2177 5811945 192 µM -1.28292638843604 0.120854555685475 no 2984 0.0997589333825993 978 5343475
SGTC_274 sirtinol 40.1 µM -1.28741364018378 0.120023602869731 no 2985 0.0989750762764981 986 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1523 st012844 44.7 µM -1.28819008892598 0.119880229140354 no 2986 0.0988399005930568 997 4274103
SGTC_3247 9135149 49.47 µM -1.28971225001247 0.119599507727056 no 2987 0.0985752923660272 984 8934436 YOR116C RPO31
SGTC_1664 st014217 9.02 µM -1.2911101306998 0.119342115188891 no 2988 0.0983327458344537 965 3982782
SGTC_432 NS 1619 61.3 µM -1.29365130568342 0.118875208978898 no 2989 0.097892946074732 978 4552 A K+/calcium channel activator.
SGTC_69 0096-0274 206.684 µM -1.29448545625168 0.118722226827372 no 2990 0.0977488948559117 999 6741392
SGTC_1794 st048918 76.9 µM -1.29808133242956 0.118064339976323 no 2991 0.0971296941416314 922 672303
SGTC_1791 st048313 56.1 µM -1.29875417523493 0.117941526333656 no 2992 0.09701415274509 960 1204976
SGTC_1681 tripelennamine 100 µM -1.29949291376975 0.117806788899929 no 2993 0.096887411883825 968 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_385 1494-0393 12.4 µM -1.30479878620156 0.116842258718987 no 2994 0.0959806862846861 1002 3090647
SGTC_127 0180-0333 59.125 µM -1.30520904469027 0.116767913540309 no 2995 0.0959108375980166 924 771601
SGTC_1192 1488-0095 21.4 µM -1.30616046575828 0.116595630422562 no 2996 0.0957489970010731 1011 915875
SGTC_213 1246-0773 967 nM -1.3079414849479 0.116273608584444 no 2997 0.0954465786001092 987 6251622
SGTC_193 1273-0060 1.558 µM -1.31332503269942 0.115304060516667 no 2998 0.0945367234299352 990 2847393 YHR072W ERG7
SGTC_2728 chlorpromazine 9.18 µM -1.31333013003905 0.115303145244437 no 2999 0.0945358649864568 1031 2726 A thorazine and dopamine antagonist.
SGTC_713 1488-1073 324 µM -1.31731813970903 0.114588644794473 no 3000 0.093866003659309 1011 3312542
SGTC_497 capsazepine 133 µM -1.31810687758279 0.114447706848776 no 3001 0.093733936259366 998 2733484 A calcium channel blocker.
SGTC_1732 st034308 51.822 µM -1.32350956512178 0.113485628758191 no 3002 0.0928329887527558 968 830119
SGTC_1851 st056236 18.9 µM -1.32604446182649 0.113036222827589 no 3003 0.0924124852670636 973 5393171
SGTC_2490 carminic acid 95.39 µM -1.32628432438423 0.11299376402229 no 3004 0.0923727685750503 981 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1848 st056003 16.4 µM -1.32854716966618 0.112593770995887 no 3005 0.0919987058036165 968 146492
SGTC_1000 4048-0884 8.67 µM -1.32987212831023 0.112360033955022 no 3006 0.0917802029874044 1004 13040088
SGTC_838 0109-0203 71.4 µM -1.33135704250358 0.112098491272548 no 3007 0.091535778548588 989 759422
SGTC_408 cantharidin 100 µM -1.33273604984312 0.111855992315617 no 3008 0.0913092192470257 997 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3087 9117406 49.47 µM -1.33505502086342 0.111449046720082 no 3009 0.090929169623534 985 42546093
SGTC_1320 1313-0481 95.3 µM -1.33699485631976 0.111109448651308 no 3010 0.0906121579165517 987 6813365 YLR208W SEC13
SGTC_1999 st074831 12.5 µM -1.33718382192691 0.111076406963352 no 3011 0.0905813206921932 990 17112523
SGTC_954 1189-0853 2.85 µM -1.337997787176 0.110934161047987 no 3012 0.0904485790655599 977 2828194
SGTC_1571 st070080 73.4 µM -1.33951853594481 0.110668749682404 no 3013 0.0902009621295456 977 4315245
SGTC_3173 9105693 49.47 µM -1.33966296556672 0.11064356653019 no 3014 0.0901774714877343 997 17096658
SGTC_917 harmaline 728.087 nM -1.34094289733206 0.110420573510832 no 3015 0.0899694965471886 975 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1674 st016616 23.6 µM -1.34289149136506 0.110081703432396 no 3016 0.0896535559861149 987 625830
SGTC_2236 dapsone 200 µM -1.34524737619664 0.109673000586227 no 3017 0.089272680698502 994 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_921 1561-0023 372 µM -1.34553356867499 0.109623425740565 no 3018 0.0892264941640484 990 24050882
SGTC_3259 9138485 49.47 µM -1.34969959404613 0.108903599416192 no 3019 0.088556181314107 992 17646153
SGTC_2763 lisinopril 49.32 µM -1.35037213731198 0.108787713378347 no 3020 0.0884483218082858 986 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2447 5741742 33.78 µM -1.35256153992613 0.108411071307342 no 3021 0.0880978731092777 1000 1776504
SGTC_2764 methyldopa 94.69 µM -1.36087892537132 0.106988788841972 no 3022 0.0867759772657767 1001 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2526 patulin 37.61 µM -1.36179075125972 0.106833688065984 no 3023 0.0866319656033511 1008 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1945 st075991 56.6 µM -1.36229829325323 0.106747425939095 no 3024 0.0865518830284187 1000 1084980
SGTC_968 1309-0633 340 µM -1.36759796311748 0.105849692337812 no 3025 0.0857189771969232 999 3761976
SGTC_2291 7917025 104.35 µM -1.36909207485129 0.105597587308965 no 3026 0.0854852476525345 997 2964612
SGTC_430 0958-0115 16.4 µM -1.36983611822872 0.105472205167481 no 3027 0.0853690323104665 991 6833180
SGTC_859 0439-0102 54.6 µM -1.37269001122932 0.104992281252757 no 3028 0.0849243678948269 994 610143
SGTC_1843 st055809 45.5 µM -1.37525815256704 0.104561763701954 no 3029 0.0845257126388686 1011 16413835
SGTC_2813 7971799 71.43 µM -1.37597619174122 0.104441622280983 no 3030 0.0844145021933973 1007 2234054
SGTC_1493 4348-0038 111 µM -1.37741839152756 0.104200617473805 no 3031 0.0841914649687227 1003 800424
SGTC_2647 atorvastatin 60.16 µM -1.37868150421879 0.103989871130024 no 3032 0.0839964872984548 986 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_67 0335-0847 266 µM -1.37913993133122 0.103913460517826 no 3033 0.0839258071038814 1017 4552207 YOR254C SEC63
SGTC_2916 7875993 68.79 µM -1.38248174717305 0.103357676870672 no 3034 0.0834119155773888 982 1299250
SGTC_572 0960-0087 17.7 µM -1.38367911475301 0.103159066483071 no 3035 0.0832283656847851 1015 6796365
SGTC_247 mechlorethamine 29.705 µM -1.38553818224304 0.102851247715769 no 3036 0.0829439828512939 996 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_327 1273-0057 3.96 µM -1.38707519999015 0.102597257387364 no 3037 0.0827094166804121 990 3108138
SGTC_2319 6033012 152.6 µM -1.39017311259488 0.102086717283198 no 3038 0.0822381580159941 1004 847246
SGTC_2765 myclobutanil 7.74 µM -1.3912846807652 0.101903980726516 no 3039 0.0820695586734247 1023 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_687 k029-0044 34.9 µM -1.39143713854939 0.101878935963897 no 3040 0.0820464546538494 1016 5829338
SGTC_451 chloral hydrate 100 µM -1.39205806561481 0.101776980426151 no 3041 0.0819524076765505 1008 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1124 fisetin 1.16336 µM -1.39491832247445 0.101308288466462 no 3042 0.0815202356039192 1009 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2752 diclazuril 33.15 µM -1.39518132866392 0.101265270403399 no 3043 0.0814805829837789 984 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2851 9015922 71.43 µM -1.39602663126821 0.101127100364863 no 3044 0.0813532378568655 991 2996893
SGTC_691 1548-0686 185 µM -1.3965662492565 0.101038968284111 no 3045 0.0812720227671443 995 46495133
SGTC_334 1502-1024 68.5 µM -1.39676479688842 0.101006554963445 no 3046 0.0812421557965527 1017 3296216
SGTC_625 k213-0058 121 µM -1.3976069211264 0.100869160653684 no 3047 0.0811155694208514 1012 3655420
SGTC_493 zm226600 134 µM -1.39910364649611 0.100625303227093 no 3048 0.0808909521984005 1018 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1166 k206-0078 225 µM -1.40247900335626 0.10007694443682 no 3049 0.0803861280792859 994 5404595
SGTC_1140 3229-1848 2.98 µM -1.40450776940624 0.0997484037027232 no 3050 0.0800838498687129 1006 2849525
SGTC_567 1080-0542 68.4 µM -1.40488866278494 0.0996868093406085 no 3051 0.0800271941787238 978 5950415
SGTC_1751 st044839 27.194 µM -1.410313814381 0.0988125215730872 no 3052 0.0792235206171261 1005 5291326
SGTC_1039 k821-0043 94 µM -1.41093448466865 0.0987128565418964 no 3053 0.0791319664085557 1031 15992768
SGTC_599 1935-0052 86.5 µM -1.41438913562856 0.0981594651143451 no 3054 0.0786238391254785 1013 9557311
SGTC_940 3232-1287 54.8 µM -1.41622940775213 0.0978656062084984 no 3055 0.0783541741993436 1010 1585493 YIL048W NEO1
SGTC_2634 4'-methoxyflavone 100 µM -1.41683945074989 0.0977683355784474 no 3056 0.0782649362820896 1012 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_167 3672-0051 66.205 µM -1.42124418937894 0.0970681078652144 no 3057 0.0776228911218554 998 3237971
SGTC_907 3448-6986 75.5 µM -1.42135001648739 0.0970513297758429 no 3058 0.0776075148512696 1009 590582
SGTC_2884 9058502 51.95 µM -1.42350319131037 0.0967104222781093 no 3059 0.0772951688235331 1007 6471554
SGTC_2310 7668677 200 µM -1.42390522576838 0.096646866592188 no 3060 0.0772369544414876 1013 2197143
SGTC_1695 st026914 34.495 µM -1.42589676840866 0.0963324855943678 no 3061 0.0769490711889422 1024 3289191
SGTC_2106 5357045 167.29 µM -1.42605771810197 0.0963071112550928 no 3062 0.0769258411140421 1012 668842
SGTC_1765 st044815 90.4 µM -1.43793650883429 0.0944479086996945 no 3063 0.0752260348270003 1017 645695
SGTC_152 4469-0003 551.229 µM -1.43821032392412 0.0944053669359343 no 3064 0.0751871934180458 1012 697280
SGTC_3061 glucosamine 200 µM -1.44852501407899 0.0928130821610162 no 3065 0.0737351377378478 999 91431 and experimental redox chemotherapeutic
SGTC_2075 5212009 200 µM -1.44867258105841 0.0927904471406776 no 3066 0.0737145205642131 1014 780898
SGTC_2747 doxorubicin 7.63 µM -1.45093042594148 0.0924446294606869 no 3067 0.0733996172833398 966 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_435 c-PAF 6.7 µM -1.45909525127193 0.091202041417032 no 3068 0.0722694465383319 999 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2649 anisomycin 9.56 µM -1.46251864702945 0.0906847429207318 no 3069 0.0717995691437018 1024 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_633 0437-0093 97.7 µM -1.46312093028404 0.0905939595118201 no 3070 0.0717171458181277 1018 2831118
SGTC_2762 leflunomide 42.06 µM -1.46414415498521 0.0904398814145931 no 3071 0.0715772824788629 1028 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1521 st012942 49.4 µM -1.46799051024618 0.0898624340470334 no 3072 0.0710534003276062 1008 24207259
SGTC_1697 st025554 27.742 µM -1.47098741987408 0.0894144154191066 no 3073 0.0706472595249167 1016 1269519
SGTC_1090 efavirenz 20.7 µM -1.47156411078809 0.0893283947981867 no 3074 0.0705693115403686 1003 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1411 3909-8223 150 µM -1.47663908710409 0.0885740522004682 no 3075 0.0698862041362648 1027 X1411
SGTC_1160 4092-0570 10.5 µM -1.47959625702266 0.0881366932468322 no 3076 0.0694905129977676 1033 4994975
SGTC_780 0109-0199 192 µM -1.48275069487139 0.0876719355710327 no 3077 0.0690703300904651 1004 610414
SGTC_2117 5521686 200 µM -1.48604920854593 0.0871879087495096 no 3078 0.0686330527464045 1029 803312
SGTC_3028 9087778 49.47 µM -1.48757130132331 0.0869652295110162 no 3079 0.0684319932812852 1008 17217395
SGTC_3254 9136651 49.47 µM -1.48808303142307 0.086890459890224 no 3080 0.0683644989253444 1040 16454030
SGTC_50 0929-0078 56.389 µM -1.48932566663027 0.086709096598136 no 3081 0.0682008160618751 979 1377751
SGTC_470 aa-861 153 µM -1.49111960163567 0.0864477700224922 no 3082 0.0679650484336176 996 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3107 9121808 49.47 µM -1.49411728288768 0.0860124058267288 no 3083 0.0675724837305331 968 662681
SGTC_2072 5231554 129 µM -1.49500591884385 0.0858836617599802 no 3084 0.067456448718722 1018 789545
SGTC_2341 7987486 176.74 µM -1.49564669280543 0.0857909170471097 no 3085 0.0673728742673165 1016 1258686
SGTC_1715 st032160 10.2275 µM -1.50314306121918 0.08471146610144 no 3086 0.066401078310421 1013 5289825
SGTC_1588 farnesol 29.9 µM -1.50622617849647 0.084270475925422 no 3087 0.0660045606693823 1017 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_119 0121-0043 24.815 µM -1.50794853576822 0.0840248717905364 no 3088 0.065783849568332 1023 1092378
SGTC_245 methotrexate 289.6 µM -1.50803391993154 0.0840127102045976 no 3089 0.0657729229338632 1007 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2306 7482397 179.52 µM -1.50823218620712 0.0839844754946381 no 3090 0.065747556170976 1040 891448
SGTC_3234 9132280 49.47 µM -1.50899426543965 0.0838760156166474 no 3091 0.0656501241323635 1011 17612295
SGTC_2390 9097792 176.6 µM -1.50928583352767 0.0838345471890136 no 3092 0.0656128766936353 1015 4497149
SGTC_2823 7987624 58.44 µM -1.51127024425304 0.0835527222640475 no 3093 0.0653598059459275 1030 2239440
SGTC_16 erodoxin 22.806 µM -1.5114483667157 0.083527460270513 no 3094 0.0653371271746808 1033 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1948 st076329 66.6 µM -1.51401106019917 0.0831646445690898 no 3095 0.0650115171725619 1029 24208413
SGTC_1739 st037196 92.5 µM -1.5148908095127 0.0830403668674934 no 3096 0.0649000290916681 1007 612214
SGTC_1562 morin hydrate 59.1 µM -1.51710269246661 0.0827285225627247 no 3097 0.064620379292242 1016 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1427 4048-4900 550 nM -1.51744438059532 0.0826804280409921 no 3098 0.0645772630232178 1029 24132586
SGTC_2109 5483026 200 µM -1.52332589231425 0.0818558673669515 no 3099 0.0638385961945307 1016 759335
SGTC_222 nsc-310342 10.666 µM -1.52865454705888 0.0811141795429653 no 3100 0.0631750529317021 1033 432556
SGTC_1831 st055328 12 µM -1.53006931655351 0.080918114383174 no 3101 0.0629997861088562 1020 1103068
SGTC_1129 3453-1384 223 µM -1.53196916885096 0.0806553873104317 no 3102 0.062765021550613 1033 1084452
SGTC_603 3794-0023 45.9 µM -1.53233771902763 0.0806044958784634 no 3103 0.0627195588940748 1041 3802260
SGTC_753 1322-0200 289 µM -1.53283314235873 0.0805361233241982 no 3104 0.0626584861890054 1034 5403907
SGTC_542 3381-0244 89.3 µM -1.53283543489294 0.080535807037211 no 3105 0.0626582036874343 1039 1112843
SGTC_1719 st032227 49.2 µM -1.5393793884353 0.0796367962705258 no 3106 0.0618558514729215 1004 3125804
SGTC_3002 9075603 71.4286 µM -1.53939066394118 0.0796352538168879 no 3107 0.0618544759402006 1011 20105405
SGTC_302 1094-0063 18.9 µM -1.54096075594901 0.0794206908179051 no 3108 0.0616631687428085 1025 5440289
SGTC_3165 9101544 49.47 µM -1.54371261147582 0.0790456882485438 no 3109 0.0613289848632673 1035 5002184
SGTC_2345 9052315 157.45 µM -1.55067636781364 0.0781027108195171 no 3110 0.060489630316179 1017 6469265
SGTC_3347 9188721 44.724 µM -1.55104268722098 0.0780533439930437 no 3111 0.060445727235696 1042 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1927 st060202 13.8 µM -1.55157846501934 0.0779811828401734 no 3112 0.0603815596137988 1009 688887
SGTC_1925 st057770 10.1 µM -1.56580836584909 0.0760831044917182 no 3113 0.0586967435633858 1017 5989122
SGTC_2723 salbutamol 83.58 µM -1.5684307259802 0.0757371872326769 no 3114 0.058390322538982 1018 9884233 β2-adrenoceptor agonist
SGTC_2565 isoliquiritigenin 100 µM -1.57054424911577 0.0754592639064275 no 3115 0.0581442742486386 997 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1622 st003707 19.4 µM -1.57344135929401 0.0750795644850737 no 3116 0.0578083282858686 1002 10140899
SGTC_2797 7859098 81.82 µM -1.57780872539401 0.0745099273414283 no 3117 0.0573047793537863 1009 972681
SGTC_3040 9091894 49.47 µM -1.5850240446874 0.0735760665276486 no 3118 0.0564804356531312 1022 25236966
SGTC_845 0330-0138 4.51 µM -1.5891021489939 0.0730522207570417 no 3119 0.0560186663552067 1030 9039800
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.59146250509948 0.0727503321594704 no 3120 0.0557527635998159 1031 229346 A bile salt which induces apoptosis.
SGTC_310 1273-0058 1.06 µM -1.59302842044541 0.0725505799157599 no 3121 0.0555769077482309 954 2734232
SGTC_596 1155-0152 116 µM -1.60094055688877 0.0715477056233076 no 3122 0.0546950428210438 1036 280313
SGTC_2326 6164455 177.58 µM -1.6023556240061 0.0713694706201917 no 3123 0.0545384959381579 1031 2888790
SGTC_356 1634-0012 32.5 µM -1.60243624181019 0.0713593266620731 no 3124 0.0545295879838159 1034 735457
SGTC_456 gingerol 170 µM -1.60271742205776 0.0713239550410001 no 3125 0.0544985276633614 1032 442793 A herb.
SGTC_1977 st070720 65.3 µM -1.60595381900448 0.0709177945224414 no 3126 0.0541420285693362 1023 682188
SGTC_3355 9151058 44.0485 µM -1.60608111870066 0.0709018550895404 no 3127 0.0541280439300749 1046 17015728
SGTC_2606 farnesol 9.78 µM -1.60977432476154 0.0704406189852182 no 3128 0.0537235661514132 1016 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_462 ag-879 158 µM -1.61333839886378 0.0699977004405348 no 3129 0.0533355042220259 1032 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1201 1889-3372 45.9 µM -1.6158438224415 0.0696876284671664 no 3130 0.0530640420630868 1022 5392199
SGTC_1293 1000-1278 195 µM -1.61598913984714 0.0696696764365993 no 3131 0.0530483306281745 1036 678847
SGTC_2271 7849410 118.62 µM -1.61762524134735 0.069467803493429 no 3132 0.0528716929783751 1043 972430
SGTC_2006 4011487 200 µM -1.61863969123663 0.0693428604404078 no 3133 0.0527624049389308 1030 45595294
SGTC_3206 9114350 49.47 µM -1.6187600683393 0.0693280458885164 no 3134 0.0527494484575586 1021 17087243
SGTC_2268 7933382 153.85 µM -1.61957564390207 0.0692277389601967 no 3135 0.0526617325460038 1012 935025 YOR257W CDC31
SGTC_1690 st023502 41.2 µM -1.62286872342521 0.0688238628500244 no 3136 0.0523087354079523 1041 24207482
SGTC_15 0266-0086 27.098 µM -1.62338408063736 0.0687608221596931 no 3137 0.0522536628196461 1058 1712902 YIL048W NEO1
SGTC_2678 equilin 100 µM -1.62556337424713 0.0684947338078981 no 3138 0.0520212859674806 1010 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3308 9128332 17.569 µM -1.62979543994901 0.0679802750998203 no 3139 0.0515723689430097 1023 17332805 YDL196W YDL196W
SGTC_2327 6189656 200 µM -1.63080707651133 0.0678577414097268 no 3140 0.0514655169003779 1032 5349088
SGTC_1296 1068-0102 11.9 µM -1.6312185324523 0.0678079529535537 no 3141 0.0514221081067227 1040 767053
SGTC_283 0987-0079 11.7 µM -1.63325079307375 0.0675624518604531 no 3142 0.0512081306183259 1036 411556
SGTC_1167 k781-0610 148 µM -1.63383302151752 0.0674922442352501 no 3143 0.0511469582986269 1010 4525169
SGTC_2205 7238770 200 µM -1.63600638096794 0.0672306690929756 no 3144 0.0509191259684314 1036 279867
SGTC_2890 9046729 58.44 µM -1.63608842734069 0.0672208097588783 no 3145 0.0509105409338561 1036 903329
SGTC_370 0180-0345 38.7 µM -1.63677064815152 0.0671388720563418 no 3146 0.05083920044315 1009 3989527
SGTC_769 0302-0231 76 µM -1.63888950882788 0.0668848800091052 no 3147 0.0506181365199547 1045 571869 YER009W NTF2
SGTC_377 3970-0964 33.1 µM -1.64006192455475 0.0667446600041482 no 3148 0.0504961460564543 1045 16481235
SGTC_3211 9128781 49.47 µM -1.64464989570148 0.066198128134847 no 3149 0.0500210154738182 1012 17194361
SGTC_953 1188-0045 9.7 µM -1.66081291310692 0.0643003283313988 no 3150 0.0483755134439556 1022 6144426
SGTC_3067 9117431 49.47 µM -1.66595434042881 0.0637055890353306 no 3151 0.0478612545224652 1052 17150885
SGTC_1604 st002052 72.4 µM -1.6689418855044 0.0633619730924567 no 3152 0.0475644487950358 1039 6254834 YHR062C RPP1
SGTC_2348 9022543 33.42 µM -1.67046807371452 0.063186994457742 no 3153 0.0474133954850631 1011 3162678 YDL140C RPO21
SGTC_355 1311-2252 105 µM -1.67059911603136 0.0631719879150367 no 3154 0.047400443610616 1052 5338538
SGTC_2880 9042983 58.44 µM -1.67374278650304 0.0628128161860679 no 3155 0.0470905804763779 1049 6464714
SGTC_927 2425-1185 123 µM -1.6788849739042 0.0622287417987935 no 3156 0.0465872317711485 1040 730375
SGTC_2375 9072683 200 µM -1.67965571371469 0.06214156371461 no 3157 0.0465121605022377 1042 16798029
SGTC_1704 st028805 70.8 µM -1.68416530271918 0.0616333940756369 no 3158 0.0460748633981508 1039 2876101
SGTC_2119 5528445 120.635 µM -1.68880720090835 0.0611137099999098 no 3159 0.045628191713803 1056 791935
SGTC_513 4245-1575 41.7 µM -1.68956516228488 0.0610291785862923 no 3160 0.045555587790308 1014 719745
SGTC_1874 staurosporine 7.6 µM -1.69971033648988 0.0599065193892697 no 3161 0.0445927120526448 1029 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2611 pyromycin 23.93 µM -1.70794554272746 0.0590071644338916 no 3162 0.0438232237847727 1049 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_893 0958-0369 48.9 µM -1.71779575322159 0.0579453875883763 no 3163 0.0429169382096372 1039 6819948
SGTC_943 3253-1379 105 µM -1.72031149644703 0.057676631703868 no 3164 0.0426879174035271 1019 668464
SGTC_2380 9035439 200 µM -1.72147986754046 0.0575521488607082 no 3165 0.0425818911822443 1041 6462575
SGTC_1594 piperine 70.1 µM -1.72324937429947 0.057364021161932 no 3166 0.0424217192364888 1050 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_874 0599-0792 117 µM -1.72786343671002 0.056875745849373 no 3167 0.0420063554493749 1042 765305
SGTC_1199 1638-0010 4.46 µM -1.72842802507073 0.0568162246675161 no 3168 0.0419557573223608 1039 3111136
SGTC_2492 derrusnin 100 µM -1.73467507190538 0.0561609056081599 no 3169 0.0413991870389492 1046 1715307 Part of coumarin class of compounds.
SGTC_1504 k297-0033 30 µM -1.73548389006464 0.0560764976333816 no 3170 0.0413275662601559 1013 4388117
SGTC_11 0438-0307 1.3 µM -1.73935000029441 0.0556744130075673 no 3171 0.0409866086786159 1047 4011476
SGTC_1117 retinoic acid 1.10837 µM -1.74415385262106 0.0551779750286193 no 3172 0.0405661328569786 1066 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_266 formosanin C 406 nM -1.74717765357463 0.0548672880236769 no 3173 0.0403032633602373 1016 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1662 st014054 52 µM -1.75695160643384 0.0538724914813875 no 3174 0.0394630291068686 1062 2838777
SGTC_3031 9088762 49.47 µM -1.75769072406061 0.0537978484373604 no 3175 0.0394000735044855 1051 205253
SGTC_1061 3448-9325 110 µM -1.76056756530093 0.0535080974574446 no 3176 0.0391558111930022 1043 723482
SGTC_1038 k292-0204 154 µM -1.7618849211887 0.0533758288163947 no 3177 0.0390443713890581 1048 4454212
SGTC_2252 omeprazole 400 µM -1.76814548823504 0.0527507771247258 no 3178 0.0385182922650404 1062 4594 A proton pump inhibitor.
SGTC_1873 rapamycin 2 nM -1.7762973417783 0.0519456204935644 no 3179 0.0378419605682993 1024 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2350 9023895 38.85 µM -1.78234213662379 0.051354906683413 no 3180 0.0373467276361515 1029 2997209
SGTC_2077 5212015 200 µM -1.78352194506508 0.0512402382229085 no 3181 0.0372506894746211 1042 780900
SGTC_1234 0326-0494 15.5 µM -1.78832740956397 0.0507752865726884 no 3182 0.0368616000954853 1056 1547813
SGTC_277 nystatin 15.5 µM -1.79215931260079 0.0504069443622642 no 3183 0.0365537250497179 1065 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1094 duloxetine 25.4 µM -1.8011799689401 0.0495482369258931 no 3184 0.0358372592618652 1047 60834 A selective serotonin reuptake inhibitor.
SGTC_2961 9083290 32.55 µM -1.81354570407704 0.0483901165202448 no 3185 0.034873848054357 1056 17741490
SGTC_2406 ethylparaben 405.7 µM -1.81548146720619 0.0482107972380548 no 3186 0.0347249757444281 1050 8434 A possible steroid mimic.
SGTC_2296 7971656 126.45 µM -1.82330766522895 0.0474912312365249 no 3187 0.0341284030070595 1048 666570
SGTC_2456 5770359 74.46 µM -1.82428829907608 0.0474016783605506 no 3188 0.0340542492181239 1048 3118787
SGTC_2354 9060492 162 µM -1.82431989222432 0.0473987954807686 no 3189 0.0340518624050861 1046 6471895
SGTC_3200 9114385 49.47 µM -1.82522656200966 0.0473161215713139 no 3190 0.0339834235177264 1037 17018030 YLR208W SEC13
SGTC_2221 6807166 181.081 µM -1.83053022127063 0.0468348245326472 no 3191 0.0335853459853516 1059 674925
SGTC_2945 9067681 61.76 µM -1.83170299278352 0.0467289297194217 no 3192 0.0334978412746605 1054 16456930
SGTC_3063 1327-0034 4 µM -1.84278052969652 0.0457381383954202 no 3193 0.0326805303403024 1041 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2546 rhodinyl acetate 100 µM -1.84490708053772 0.045549882351123 no 3194 0.0325255282577052 1039 6708682
SGTC_867 0518-0118 155 µM -1.84582067644379 0.0454691964868444 no 3195 0.0324591236806128 1035 6848158
SGTC_990 3985-0011 41.3 µM -1.84632535288854 0.0454246743862665 no 3196 0.0324224893342677 1031 5399565 YGL099W LSG1
SGTC_1490 4089-0339 670 nM -1.85044579638183 0.0450624829223363 no 3197 0.0321246617804376 1060 742542
SGTC_1748 st037455 53.6035 µM -1.85849518279055 0.0443616395956242 no 3198 0.0315493634176118 1059 580690
SGTC_3081 9117243 49.47 µM -1.86030935670727 0.0442049024825012 no 3199 0.0314208852607722 1062 45595589
SGTC_729 4092-0585 94.1 µM -1.86042813052515 0.0441946565059209 no 3200 0.0314124889154415 1039 2169061
SGTC_592 k241-0073 46.5 µM -1.86188069168289 0.0440695066956031 no 3201 0.0313099546125019 1069 4230158
SGTC_2053 5265679 138 µM -1.86251804208794 0.0440146841124003 no 3202 0.031265052364592 1032 764595
SGTC_1041 0206-0046 107 µM -1.86350261626247 0.0439301027043331 no 3203 0.0311957923977058 1054 50494
SGTC_1430 4049-0248 69.1 µM -1.87749609439443 0.0427420840748231 no 3204 0.0302250660656087 1056 22774488
SGTC_3248 9135562 49.47 µM -1.8776319168768 0.0427306815607911 no 3205 0.0302157681808638 1061 17650701
SGTC_795 0685-0265 78 µM -1.87782264699824 0.0427146736140084 no 3206 0.0302027155325373 1051 302754
SGTC_1230 0170-0365 3.77 µM -1.87863166595375 0.0426468266754513 no 3207 0.0301474021290077 1027 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2689 tacrolimus 100 µM -1.87880993700342 0.0426318880113954 no 3208 0.0301352248640124 1018 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_841 0251-0215 91.2 µM -1.87916366667851 0.0426022588835829 no 3209 0.0301110745164699 1070 3888614
SGTC_2016 5121758 140 µM -1.88414398009402 0.042186862408106 no 3210 0.0297727513204629 1038 2795203
SGTC_22 0964-0034 14.468 µM -1.89049662131978 0.0416617665071954 no 3211 0.0293457860131169 1061 138402
SGTC_1318 1280-3875 124 µM -1.8971475572749 0.041117699946721 no 3212 0.0289042330166882 1055 373245
SGTC_2700 st077718 96.8 µM -1.90932414591354 0.040136555214307 no 3213 0.028110144659122 1067 904970
SGTC_996 3970-0799 1.8 µM -1.91731029771328 0.039503450884665 no 3214 0.0275992612317699 1046 6615648 YGL040C HEM2
SGTC_2655 perillic acid 100 µM -1.91854196250767 0.0394065372554605 no 3215 0.0275211633182953 1076 5702197 An apoptosis inducer.
SGTC_598 3937-0236 20.2 µM -1.92893772236071 0.0385962303140835 no 3216 0.0268692970485549 1062 1379313
SGTC_2371 9071574 200 µM -1.93096929240094 0.0384394746619539 no 3217 0.0267434250058359 1071 45596039
SGTC_892 0929-0076 29 µM -1.9354379434271 0.0380965000392299 no 3218 0.0264682884645119 1057 5751038
SGTC_1648 st011736 69.8 µM -1.93667262601959 0.0380021779512855 no 3219 0.0263926869879295 1072 2855514
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.93785705920001 0.0379118737358283 no 3220 0.0263203320498876 1050 6708630 An antioxidant.
SGTC_2515 chrysin 20.77 µM -1.94034814614658 0.0377225182572166 no 3221 0.0261686969239885 1044 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_702 1488-0190 94 µM -1.94205929815985 0.0375928959407301 no 3222 0.0260649610522609 1065 949357
SGTC_2088 5278280 127.392 µM -1.94382761597631 0.0374593255545219 no 3223 0.0259581211816537 1069 791502
SGTC_1621 st003705 32.4 µM -1.94498598878052 0.0373720378324491 no 3224 0.0258883323312949 1055 24207032
SGTC_3196 9111891 49.47 µM -1.96007140823613 0.0362503925784016 no 3225 0.0249937222754964 1070 18891510
SGTC_1450 4112-4260 37.6 µM -1.96361777507588 0.0359907503653421 no 3226 0.0247872172410986 1052 1633175
SGTC_2922 7999257 32.47 µM -1.96800337463489 0.0356717735602597 no 3227 0.0245338247134207 1058 2988377
SGTC_1659 st012954 42.1 µM -1.96906672207768 0.0355947833667864 no 3228 0.0244727148270149 1061 24207262
SGTC_2533 agelasine 13.65 µM -1.97082810276007 0.0354675527706081 no 3229 0.0243717705457013 1052 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1027 k015-0025 8.67 µM -1.9750730867511 0.0351624547283899 no 3230 0.0241299272588487 1066 3598955
SGTC_2041 5107442 45.335 µM -1.97859854067355 0.0349107109047923 no 3231 0.0239306120501706 1067 793005
SGTC_650 1328-0195 38 µM -1.98034061744564 0.0347868608177012 no 3232 0.0238326338353423 1071 2780821
SGTC_2704 st078022 71.1 µM -1.981905279879 0.0346759314463866 no 3233 0.0237449214530626 1068 54697681
SGTC_2965 9082772 38.63 µM -1.98813023217201 0.0342374763956833 no 3234 0.0233986442823491 916 16459634
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.99447556206024 0.0337952430309993 no 3235 0.023050054020366 1055 688788
SGTC_2718 lomofungin 53.02 µM -1.99559649366564 0.0337176110396113 no 3236 0.0229889307496985 1064 5351222 A RNA synthesis inhibitor.
SGTC_329 k048-0121 21.3 µM -1.99993839510115 0.0334182892385374 no 3237 0.0227534582611209 1073 6832902
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.00520894114683 0.0330578918678851 no 3238 0.0224703573096366 1065 2333 A French combination drug.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.00774281824508 0.0328857699264808 no 3239 0.0223353140178379 1048 4000243
SGTC_452 diindolylmethane 8 µM -2.00996303684124 0.0327355620956078 no 3240 0.0222175505639122 1068 3071 Inhibits expression of several cancer promoting factors.
SGTC_1079 idarubicin 2.36 µM -2.01318820350602 0.0325183730992037 no 3241 0.0220474168881294 1066 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_23 0213-0011 39.996 µM -2.01656702111828 0.0322921132883503 no 3242 0.0218703587514644 1062 627608
SGTC_1561 5-methoxyflavone 52.9 µM -2.03354926497554 0.0311745025250713 no 3243 0.0209985308146194 1045 94525
SGTC_2275 7947463 200 µM -2.03964083288101 0.0307814919692827 no 3244 0.0206930559740707 1043 1225414
SGTC_888 0916-0002 6.97 µM -2.04774371679889 0.030265082561003 no 3245 0.0202925589177006 1069 2802138 YIL048W NEO1
SGTC_1713 st033146 12.748 µM -2.05889187878809 0.0295663470375334 no 3246 0.0197522986228899 1071 674619
SGTC_2002 4023503 131 µM -2.0606818267292 0.0294554154549757 no 3247 0.0196667022614654 1060 4736863 YCR052W RSC6
SGTC_3228 9131799 49.47 µM -2.06567650396124 0.0291476976402406 no 3248 0.0194295176501516 1078 17015818
SGTC_3352 9151559 45.5865 µM -2.06658205489224 0.0290921944079467 no 3249 0.0193867765922827 1073 17159339
SGTC_3274 9138298 49.47 µM -2.07447658855342 0.0286120309122628 no 3250 0.019017535416294 1076 17015756
SGTC_313 3474-0040 5.03 µM -2.08074018150162 0.0282357707352231 no 3251 0.0187288470352085 1075 1043375 YIL048W NEO1
SGTC_868 0527-0199 213 µM -2.09117833957037 0.0276178952252637 no 3252 0.0182560401266911 1073 2849450
SGTC_1652 st011932 78 µM -2.09217241822863 0.0275596441021126 no 3253 0.018211547432643 1058 1551076
SGTC_3108 9121785 49.47 µM -2.09973784725544 0.0271196718250676 no 3254 0.0178759541575366 1013 17140271
SGTC_1603 st002045 67.8 µM -2.13476516033556 0.0251583183492677 no 3255 0.0163900987226949 1077 5887985
SGTC_2080 5212524 12.4 µM -2.14068482385101 0.0248388841170784 no 3256 0.0161497315847556 1066 260183
SGTC_1839 st053978 48 µM -2.16163250621447 0.0237357033213197 no 3257 0.0153232569071527 1081 3788398
SGTC_566 0958-0068 16.5 µM -2.16333684400278 0.0236477878989475 no 3258 0.0152576406264219 1053 6815365
SGTC_1003 4049-0218 100 µM -2.16773929328139 0.0234219613814261 no 3259 0.015089264015485 1067 295161
SGTC_2172 5754775 163.918 µM -2.17018302353836 0.0232973936947488 no 3260 0.0149964918104789 1059 2263357
SGTC_2308 7584454 197.62 µM -2.17255500121515 0.0231770173046918 no 3261 0.0149069128933275 1071 893577
SGTC_737 1950-0117 57.9 µM -2.18617910450811 0.0224957001262427 no 3262 0.0144012521915462 1065 5393513
SGTC_2013 4024628 200 µM -2.1934202389099 0.0221405096883913 no 3263 0.0141385577294639 1070 5230760
SGTC_569 4130-2812 160 µM -2.2116575946335 0.0212668512927715 no 3264 0.0134951663101856 1077 743552
SGTC_1161 k007-0610 110 µM -2.21199193683717 0.0212511108092431 no 3265 0.0134836110343139 1045 5843850
SGTC_2821 7996764 71.43 µM -2.24139232647271 0.0199049770054335 no 3266 0.0125003365679221 1053 2987135
SGTC_1133 3473-0247 50 µM -2.25713513565585 0.0192144044680671 no 3267 0.0119998159976664 1047 711311
SGTC_991 3996-0057 64.7 µM -2.25884986205538 0.0191404312441163 no 3268 0.0119463628396363 1076 715343
SGTC_1842 st055362 61.2 µM -2.25981336186606 0.0190989722471736 no 3269 0.0119164183820912 1082 676032
SGTC_394 menadione 8.33 µM -2.26416750406944 0.0189125662286497 no 3270 0.0117819072098072 1064 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2022 5136654 200 µM -2.29668114477353 0.0175689426334414 no 3271 0.010818482919253 1080 1713771
SGTC_2725 haloperidol 53.21 µM -2.30019511630274 0.017428730411905 no 3272 0.0107185841948376 1070 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2912 7964298 10.93 µM -2.30850978191332 0.0171007645592833 no 3273 0.0104853997025021 1063 2975850
SGTC_1266 0828-0227 32.9 µM -2.31522912970332 0.016839592088798 no 3274 0.0103001979428301 1083 3913820
SGTC_2754 granisetron 64.02 µM -2.31832479933804 0.016720419885619 no 3275 0.0102158378057181 1071 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_255 tunicamycin 200.472 nM -2.32033564491941 0.0166433966880188 no 3276 0.0101613636454991 1058 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1060 3448-7350 82 µM -2.32105316974212 0.0166159862932151 no 3277 0.0101419872066063 1076 570178
SGTC_2020 4017018 200 µM -2.32857598733337 0.0163309229333732 no 3278 0.00994076969555812 1081 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_125 0133-0007 11.75 µM -2.33847465032957 0.0159622205315742 no 3279 0.00968131959725968 1082 26541
SGTC_1975 st070967 30.8 µM -2.3404902412706 0.0158880252782228 no 3280 0.00962922085178659 1076 261391
SGTC_875 0709-0210 25.7 µM -2.35517885767825 0.0153562045805736 no 3281 0.00925689605840741 1086 6251364
SGTC_2794 7785382 27.27 µM -2.36559726703695 0.0149883234792156 no 3282 0.0090005070410823 1061 2205081
SGTC_2339 9000433 200 µM -2.37112434819809 0.0147962523260961 no 3283 0.00886703179844462 1073 2988954
SGTC_3224 9130643 49.47 µM -2.37335936503964 0.0147191866361451 no 3284 0.00881355217243081 1070 17644395
SGTC_103 0844-0104 51.839 µM -2.38592392656672 0.0142923439232202 no 3285 0.00851813736115122 1061 5375804
SGTC_2908 7930301 100 µM -2.39172726715536 0.0140988198807889 no 3286 0.00838464914579161 1070 2223178
SGTC_2873 9040596 71.43 µM -2.39334283777598 0.014045348908712 no 3287 0.00834781617127399 1078 6463863
SGTC_42 0133-0086 60.653 µM -2.3968174836804 0.0139309395453179 no 3288 0.00826907964122506 1071 162923 Model of phenazepam hydroxylation.
SGTC_2743 auranofin 4.32 µM -2.40021977561939 0.0138196920535566 no 3289 0.00819261545066357 1078 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2997 9067075 71.4286 µM -2.41739742776867 0.0132696464195414 no 3290 0.00781596951139699 1070 27209819
SGTC_140 0062-0056 502.533 µM -2.42622996673056 0.0129942556480029 no 3291 0.00762829966560036 1082 3758964
SGTC_150 3970-0969 77.2 µM -2.42872196991111 0.0129174565363318 no 3292 0.0075760734229877 1073 6615640
SGTC_212 3807-4682 38.772 µM -2.43612379372425 0.0126916554633935 no 3293 0.00742280146256764 1086 3125501 YBL034C STU1
SGTC_2610 ononetin 44.17 µM -2.43629402368122 0.0126865028394423 no 3294 0.00741930883352354 1078 259632
SGTC_440 fluspirilene 35.1 µM -2.44392529288995 0.0124573669671022 no 3295 0.00726421731717616 1082 3396 An atypical antipsychotic.
SGTC_203 k066-0004 30.888 µM -2.47712952641924 0.0115016151148009 no 3296 0.00662219136978137 1089 6795412
SGTC_350 k064-0020 19.8 µM -2.47797041186999 0.0114782616353101 no 3297 0.00660660510384061 1049 2790705
SGTC_2334 9017922 200 µM -2.52406055251787 0.0102596503501711 no 3298 0.00580039722292241 1078 3163164
SGTC_407 eburnamonine 100 µM -2.5269648120078 0.0101867896816341 no 3299 0.0057526514789826 1076 3195
SGTC_376 3970-0862 59.1 µM -2.53821887623548 0.00990869960391642 no 3300 0.00557091387322372 1079 3135186
SGTC_2481 5478948 45.16 µM -2.54395105719675 0.00976962132723272 no 3301 0.00548032205587257 1079 77792
SGTC_1876 myriocin 605 nM -2.54738986107727 0.00968700752070021 no 3302 0.00542660534703649 1080 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_454 lyso-paf C-16 6.67 µM -2.57339934749087 0.00908168527613216 no 3303 0.00503524669768129 1086 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1228 0124-0032 52.5 µM -2.58505958434775 0.00882124513423821 no 3304 0.00486810850990019 1086 X1228
SGTC_2993 9054257 71.4286 µM -2.58672872298408 0.00878450441919714 no 3305 0.00484459204462802 1070 6470217 YGL055W OLE1
SGTC_2374 9071832 200 µM -2.60274838055764 0.00843865005466307 no 3306 0.0046239899651074 1083 17381698
SGTC_1259 0671-0132 43 µM -2.62035981497972 0.00807227589180291 no 3307 0.00439185175396471 1086 X1259
SGTC_2964 9083345 53.42 µM -2.62959016599534 0.00788589743200795 no 3308 0.00427439292457579 1071 17741579
SGTC_372 0155-0182 15.9 µM -2.63612656969856 0.00775621430503839 no 3309 0.00419292227439571 962 771486
SGTC_2929 9013348 24.6 µM -2.6400694461336 0.00767889784901184 no 3310 0.0041444520066853 1079 2995952
SGTC_2273 7815444 169.05 µM -2.64764415033379 0.00753226598105415 no 3311 0.00405273975448305 1082 2824616
SGTC_501 nsc-95397 161 µM -2.6803606081344 0.00692689327398408 no 3312 0.00367714434007137 1080 262093
SGTC_2925 9010536 32.5 µM -2.68081782300582 0.00691874669996197 no 3313 0.00367212431108476 1009 2994177
SGTC_1115 galangin 695.678 nM -2.68385405456701 0.00686486196636388 no 3314 0.00363894345089082 1094 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_326 k292-0812 17.5 µM -2.68662265776615 0.00681605032255675 no 3315 0.00360892209031887 1085 3579357
SGTC_3305 9127027 53.8275 µM -2.69511865626276 0.00666817088450666 no 3316 0.00351817845318417 1083 41905295
SGTC_1623 st003709 20.3 µM -2.70141341460083 0.00656044188002456 no 3317 0.00345227277553409 1088 16192618
SGTC_322 k048-0136 19.3 µM -2.70807344036529 0.00644814006215223 no 3318 0.00338375225523043 1091 6823282
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.75340843709943 0.00572787495657933 no 3319 0.00294891326648975 1080 23847180
SGTC_1833 st055984 71 µM -2.79004056245373 0.00519900916928276 no 3320 0.00263507192595094 1088 676288
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.79509642926665 0.00512953685931113 no 3321 0.00259421183159312 1069 4330530
SGTC_2324 6149169 200 µM -2.80015130935131 0.00506090540786695 no 3322 0.00255393290226102 1083 2888231
SGTC_1154 4088-0362 150 µM -2.80341033171171 0.00501709146957801 no 3323 0.00252826454097736 1084 6618304
SGTC_676 falcarinol 140 µM -2.83872595039191 0.00456353583259628 no 3324 0.00226470194570765 1078 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2229 7354935 190 µM -2.84119252871442 0.00453326977695378 no 3325 0.00224725846132008 1092 318112
SGTC_1416 3966-0321 25.3 µM -2.84177737340287 0.00452611979951598 no 3326 0.00224314037106233 1093 582530 YLR208W SEC13
SGTC_3269 9137823 49.47 µM -2.84467112468227 0.00449089039959621 no 3327 0.00222286492027882 1087 17682936
SGTC_2264 7948757 110.76 µM -2.85081708788552 0.00441687880364446 no 3328 0.00218035233465012 1090 2971411
SGTC_839 0122-0028 230 µM -2.85110693398265 0.00441341544993561 no 3329 0.00217836574508845 1087 759448
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.85617716165461 0.00435322276928007 no 3330 0.00214387904824538 1086 115019
SGTC_1650 st011916 45.8 µM -2.87955986201065 0.00408501667285939 no 3331 0.00199115344474104 1092 242528
SGTC_1730 st033808 45.1 µM -2.90998443328546 0.00375821624851452 no 3332 0.00180723379112791 1084 1045166
SGTC_2679 rapamycin 1 nM -2.92102546194139 0.00364554675068737 no 3333 0.00174440656583628 1055 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2331 7980721 200 µM -2.96504831139509 0.00322584195868319 no 3334 0.00151317699754695 1084 2981221
SGTC_2396 5342950 42.78 µM -3.02857932238271 0.00269662272393858 no 3335 0.00122853281914871 1066 1886677
SGTC_1374 2889-5571 141 µM -3.0313357490224 0.0026755465447727 no 3336 0.00121737173445919 1091 2853281
SGTC_314 1671-0008 2.74 µM -3.09659165456891 0.00221809675797891 no 3337 0.000978796669581046 1081 3913060
SGTC_110 0850-0284 111.64 µM -3.18792132548169 0.00169653730823178 no 3338 0.000716497602602619 1090 3906265
SGTC_105 0111-0055 734.78 µM -3.19399318641369 0.0016661812822168 no 3339 0.000701597145612696 1093 5179370
SGTC_2695 st077686 51.995 µM -3.2234944480447 0.00152561267253997 no 3340 0.000633183766820367 1089 2876092
SGTC_1685 st024049 53.0905 µM -3.26031548719364 0.00136536636970214 no 3341 0.000556441749942663 1095 1941139
SGTC_1726 st035556 14.5795 µM -3.26115650137798 0.00136189288199885 no 3342 0.000554793901167994 1089 5919439
SGTC_1844 rapamycin 4 nM -3.3394613289175 0.0010717052540499 no 3343 0.00041970518562175 1075 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2920 7982904 15.77 µM -3.34023785014808 0.00106913556315922 no 3344 0.000418533330502458 1092 6456808
SGTC_1030 k029-0042 36.7 µM -3.41689730522199 0.000841555179863623 yes 3345 0.000316695837446969 1095 6080581
SGTC_108 0509-0257 621.132 µM -3.4485519127141 0.000761318817100501 yes 3346 0.000281800560217889 1093 536624
SGTC_73 0327-0325 16.231 µM -3.48942428623985 0.000668137471576972 yes 3347 0.000242031081890984 1067 53298
SGTC_857 0438-0306 1.35 µM -3.53958842981223 0.000568177328012714 yes 3348 0.000200375741249205 1094 4686136
SGTC_2373 9071805 200 µM -3.60270116590645 0.000462055936719658 yes 3349 0.000157463753848536 1092 10149009
SGTC_204 PMA1.184 62.41 µM -3.61932124827767 0.000437340136623501 yes 3350 0.000147688382608193 1093 2252213 YGL008C PMA1
SGTC_2307 7538926 6.34 µM -3.7540733030904 0.00027777649749712 yes 3351 8.69919735246528e-05 1091 96582
SGTC_686 1319-0111 510 µM -3.91732591137465 0.00015717878120605 yes 3352 4.47683310606078e-05 1093 4562600
SGTC_673 1082-0474 110 µM -4.19561831898792 5.66632832655089e-05 yes 3353 1.36064090208569e-05 1092 3098046
SGTC_1372 2752-0194 270 µM -4.7802614340672 5.41367485481906e-06 yes 3354 8.75336946269224e-07 1095 823334
SGTC_20 0481-0013 4.944 µM -4.78227637127171 5.36745030948577e-06 yes 3355 8.66605791877092e-07 1095 182045
SGTC_2947 9072639 7.68 µM -5.0769154422592 1.4779028142943e-06 yes 3356 1.91805743273226e-07 1094 16488146