SGTCid condition conc unit GEP3|YOR205C.score GEP3|YOR205C.strain.pval GEP3|YOR205C.strain.significant GEP3|YOR205C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1622 st003707 19.4 µM 9.48393955176613 1.22129309347593e-20 yes 1 1.22430007957981e-21 5 10140899 SGTC_236 1509-0011 5.31 µM 8.20111652646289 6.36996510825787e-16 yes 2 1.19082265011335e-16 244 3107280 SGTC_173 1273-0061 2.693 µM 6.99803598691045 4.23047919051575e-12 yes 3 1.29787713505946e-12 86 2847414 YPL266W DIM1 SGTC_10 0279-0212 42.575 µM 6.85458293908517 1.10510061564718e-11 yes 4 3.57604335720893e-12 15 39851 YBR002C RER2 SGTC_1627 st003713 25.6 µM 6.37268896039461 2.42090474616358e-10 yes 5 9.28711743984602e-11 25 16195070 YER133W GLC7 SGTC_385 1494-0393 12.4 µM 5.85710756453395 5.19570240188688e-09 yes 6 2.35499043583512e-09 1 3090647 SGTC_1624 st003710 6.25 µM 5.79555604546848 7.37140713832442e-09 yes 7 3.40475909885016e-09 16 24207033 SGTC_1051 3253-3903 78 µM 5.72583924109682 1.09091054946031e-08 yes 8 5.14618251458766e-09 3 5509239 SGTC_831 k061-1017 217 µM 5.61089606372953 2.06180981409923e-08 yes 9 1.0064081741408e-08 14 1240153 SGTC_1052 3253-3998 198 µM 5.45412236542167 4.81798579854225e-08 yes 10 2.46076521143156e-08 3 5450317 SGTC_63 0099-0242 26.702 µM 5.35910682361931 7.97132471522018e-08 yes 11 4.18171974089075e-08 44 3898502 YLR359W ADE13 SGTC_3157 9099274 49.47 µM 5.31015480979586 1.02989069682866e-07 yes 12 5.47660776619526e-08 4 17217662 SGTC_314 1671-0008 2.74 µM 5.07623897219557 3.39907400890844e-07 yes 13 1.92489527644604e-07 19 3913060 SGTC_832 4083-0019 164 µM 4.66283636435696 2.48338230052668e-06 yes 14 1.55940369738493e-06 54 1990758 SGTC_310 1273-0058 1.06 µM 4.58717726329156 3.51424775588729e-06 yes 15 2.24639596617731e-06 203 2734232 SGTC_1329 1447-1697 50.6 µM 4.55917133987265 3.9909699132376e-06 yes 16 2.56779297701869e-06 9 2840515 SGTC_727 3032-0951 202 µM 4.50333530797405 5.13222484926949e-06 yes 17 3.3447605963627e-06 20 3652836 SGTC_2232 chlorophetanol 41.5365 µM 4.49799478068886 5.25640525821547e-06 yes 18 3.42986905083534e-06 99 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1921 5740136 50 µM 4.44465156295444 6.66479089513314e-06 yes 19 4.40172140739488e-06 42 1774243 SGTC_2622 2-methoxyxanthone 59.94 µM 4.42598193168557 7.23779784794095e-06 yes 20 4.80022800910854e-06 9 71034 A hepatoprotective. SGTC_908 3448-7491 47.7 µM 4.2302116325254 1.6865701971807e-05 yes 21 1.16735779594966e-05 105 1203031 SGTC_1203 3992-3522 103 µM 4.22504369599505 1.72385254647282e-05 yes 22 1.19447209853492e-05 24 5322312 SGTC_275 trichlorophene 5.69 µM 4.20869025944025 1.84705422572897e-05 yes 23 1.28427600120013e-05 212 62616 SGTC_556 4058-0063 51.5 µM 4.15789208011821 2.2852768293681e-05 yes 24 1.60598844992366e-05 22 6615692 SGTC_211 3455-0679 143.504 µM 4.14643563250263 2.3969113265705e-05 yes 25 1.68845527415847e-05 15 748649 SGTC_700 3453-2283 142 µM 4.09784194888416 2.93049087515918e-05 yes 26 2.08509927013366e-05 23 565664 SGTC_2980 9014342 25.29 µM 4.05843464518773 3.44391257044996e-05 yes 27 2.47013774392783e-05 28 2996599 SGTC_2231 micatex 6.853 µM 4.00090142363426 4.34838183955653e-05 yes 28 3.15508213511629e-05 15 20737 An antifungal of unknown mechanism. SGTC_2391 6285546 200 µM 3.97882460299871 4.75168638809517e-05 yes 29 3.46284041301124e-05 18 846083 SGTC_2010 4012422 159 µM 3.91836193688185 6.04470329717155e-05 yes 30 4.45763850910287e-05 22 952393 SGTC_3203 9113543 49.47 µM 3.90567552123097 6.35516746324119e-05 yes 31 4.69812631152067e-05 31 17018012 SGTC_3115 9123671 49.47 µM 3.89829109562328 6.54273775003805e-05 yes 32 4.84369608549341e-05 4 3286988 SGTC_2101 5377231 179.231 µM 3.88213944503032 6.97134152802536e-05 yes 33 5.17707355172418e-05 8 2844213 SGTC_3104 9120930 49.47 µM 3.768039327511 0.000108419242648358 yes 34 8.22673927747634e-05 15 17014836 SGTC_458 nppb 133 µM 3.74371739254872 0.000118942549018132 yes 35 9.06587918220495e-05 16 4549 A chloride channel blocker. SGTC_1623 st003709 20.3 µM 3.73096591667408 0.000124835477835765 yes 36 9.5373515445966e-05 86 16192618 SGTC_1159 4092-0538 61.2 µM 3.715153354374 0.000132523503356586 yes 37 0.000101540246672117 38 717301 SGTC_3209 9113616 49.47 µM 3.70571935367087 0.000137319412916269 yes 38 0.000105395803276395 33 16649353 SGTC_1883 5-benzylidenerhodanine 20 µM 3.67454389486658 0.000154350128739266 yes 39 0.000119137339919588 81 1273210 SGTC_3158 9100007 49.47 µM 3.67392366550164 0.00015470820511312 yes 40 0.000119427058304163 27 19297233 SGTC_58 0957-0393 9 µM 3.6652243094746 0.000159813261575566 yes 41 0.00012356094656523 405 6997992 SGTC_1904 st060225 78 µM 3.64575992226992 0.000171812158911058 yes 42 0.00013330139428669 28 66595 SGTC_118 0083-0097 135.343 µM 3.62794643153643 0.000183527078574206 yes 43 0.000142842257423361 169 5207356 SGTC_2403 6032726 181.2 µM 3.57768637210987 0.000220731758696774 yes 44 0.000173324518971942 48 2881040 SGTC_1583 clindamycin 39.6 µM 3.57534627236141 0.000222624808895739 yes 45 0.000174882325080277 26 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_894 0960-0238 55.9 µM 3.55427221727666 0.000240368756613241 yes 46 0.00018951333984359 17 6741907 YDL195W SEC31 SGTC_19 0279-0214 38.434 µM 3.48888077273479 0.000304180654476242 yes 47 0.000242523721923841 61 3566274 YBR002C RER2 SGTC_2680 butyl paraben 22.24 µM 3.47597281379881 0.000318508941441103 yes 48 0.000254501940726317 15 7184 An antifungal and steroid mimetic. SGTC_2037 5169046 200 µM 3.35839678553948 0.000481129511587567 yes 49 0.000391979961616866 25 5718022 SGTC_1165 k072-0275 30.3 µM 3.32808841138168 0.000534048970276289 yes 50 0.000437220553926574 63 6153523 YGL055W OLE1 SGTC_2673 kobusone 100 µM 3.3047156864052 0.000578481398747131 yes 51 0.000475363955472673 14 6710676 An epoxy ketone and protein crosslinker. SGTC_767 0929-0023 86 µM 3.29832781408281 0.000591206195022903 yes 52 0.000486312558680237 130 1204563 SGTC_1727 st034309 9.9045 µM 3.29769905710105 0.000592472575715128 yes 53 0.000487402757566825 76 870305 SGTC_933 2914-0560 114 µM 3.26922577490475 0.000652517500157805 yes 54 0.000539211068628216 52 463887 SGTC_330 1488-0319 80.1 µM 3.25773008634452 0.000678313648787479 yes 55 0.000561535861246793 32 6846614 SGTC_2345 9052315 157.45 µM 3.2544131696759 0.000685929764618484 yes 56 0.000568134448418533 48 6469265 SGTC_1318 1280-3875 124 µM 3.24803006069751 0.000700808675027112 yes 57 0.000581034963985054 57 373245 SGTC_120 rhodamine 6G 52.259 µM 3.22119894155206 0.000766663521279899 yes 58 0.000638277511270044 71 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3117 9124945 49.47 µM 3.20154718751748 0.000818462798541922 yes 59 0.000683458424032641 19 17592065 SGTC_1742 st038235 28.8875 µM 3.18228517177049 0.000872342526049835 yes 60 0.000730589350413188 160 564103 YBR002C RER2 SGTC_2987 9018338 71.43 µM 3.13343913372478 0.00102392176615101 no 61 0.000863853734955627 59 5055682 SGTC_1457 k015-0032 57.3 µM 3.10083473219029 0.00113816537730713 no 62 0.000964879819650074 81 4302660 SGTC_3205 9113483 49.47 µM 3.07879779756791 0.00122187229016251 no 63 0.0010391884644698 75 17018033 SGTC_2032 5185112 25.99 µM 3.07789150811138 0.00122543247352022 no 64 0.00104235398529413 34 5718189 SGTC_820 1582-0060 59.9 µM 3.07232864076061 0.00124749387695424 no 65 0.00106197871224432 76 3848840 SGTC_2225 6654152 15.4 µM 3.0228300837499 0.00146040137451222 no 66 0.00125211404631061 37 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2713 st079149 53.4 µM 3.02129620951603 0.00146749972380242 no 67 0.00125847501977312 61 3103253 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 3.01582649401534 0.00149306914684086 no 68 0.00128139931200915 48 7104 SGTC_1922 5578187 25 µM 2.98917178985894 0.00162358653127392 no 69 0.00139867401793114 87 1350412 SGTC_3258 9138477 49.47 µM 2.978066646566 0.00168096807620107 no 70 0.00145036451164877 36 4970355 SGTC_601 0986-0029 62.9 µM 2.96376308454682 0.00175759607909796 no 71 0.00151951080753585 93 24747981 SGTC_2193 5925765 200 µM 2.94163513715068 0.00188241907773275 no 72 0.00163242177228923 26 877370 SGTC_2691 st077356 60.2 µM 2.93866080973018 0.00189979784441319 no 73 0.00164816802552266 80 2839272 SGTC_1831 st055328 12 µM 2.92362264317903 0.00198991725069638 no 74 0.00172991949408426 75 1103068 SGTC_1258 0671-0043 57.1 µM 2.89612001313277 0.00216483342753643 no 75 0.00188903941451617 82 4298767 SGTC_2826 7992541 19.48 µM 2.87585951426661 0.00230248249570196 no 76 0.00201464500398174 62 2985066 SGTC_40 0327-0103 19.753 µM 2.87512833707507 0.00230759508557448 no 77 0.00201931652536624 85 409036 SGTC_386 1509-0011 3.07 µM 2.8168904164483 0.00274938855441901 no 78 0.00242455337418357 215 3107280 SGTC_932 2857-0803 154 µM 2.81184165795839 0.0027910727770187 no 79 0.00246293728450943 80 674898 SGTC_2183 6420625 130.508 µM 2.80848172009217 0.00281912867638331 no 80 0.00248878541074772 141 2897619 SGTC_2333 9017922 200 µM 2.79929708899128 0.0028971243876489 no 81 0.00256069966687549 91 3163164 SGTC_68 0986-0284 82.829 µM 2.79720967359979 0.00291511979379056 no 82 0.00257730350097867 159 423278 YIL048W NEO1 SGTC_1764 st044502 93.5 µM 2.7912832087234 0.00296676176005922 no 83 0.00262497568171568 103 8407 SGTC_51 1013-0126 23.419 µM 2.7831920166887 0.00303859778206738 no 84 0.00269134696759669 73 1627850 SGTC_2053 5265679 138 µM 2.78294416830506 0.00304082277799073 no 85 0.00269340375382908 97 764595 SGTC_954 1189-0853 2.85 µM 2.74722782455131 0.00337722481050696 no 86 0.00300506848793244 111 2828194 SGTC_1821 st053465 65.6 µM 2.7355724895364 0.00349403143837014 no 87 0.00311359345192641 51 675086 SGTC_116 0155-0182 31.788 µM 2.71868026906694 0.00366976364696291 no 88 0.00327714648889285 191 771486 SGTC_2823 7987624 58.44 µM 2.70548076794336 0.00381255532519631 no 89 0.00341027987747165 122 2239440 SGTC_2749 bexarotene 57.39 µM 2.67177095370622 0.00420008538826698 no 90 0.00377260652128937 108 82146 An retinoic acid receptor inhibitor. SGTC_1228 0124-0032 52.5 µM 2.66930915720115 0.0042297211235433 no 91 0.00380037266899637 96 X1228 SGTC_1768 st044301 37.178 µM 2.65741116768982 0.00437560434073162 no 92 0.00393716698395092 93 3931349 SGTC_2144 5628481 200 µM 2.64955264906772 0.00447440823545983 no 93 0.00402992065579609 93 2818399 SGTC_1273 0849-0096 14.1 µM 2.64621167714576 0.00451701395542169 no 94 0.00406994313698476 85 5286025 SGTC_537 1334-0398 209 µM 2.6418983658041 0.00457255498361031 no 95 0.00412213955194152 104 5846986 SGTC_3281 9140613 49.47 µM 2.63676189151119 0.00463949024343977 no 96 0.00418507807648862 90 16013766 SGTC_708 3448-5400 146 µM 2.62770137914779 0.00475969511885094 no 97 0.00429819714916781 141 3462195 SGTC_2181 6316240 54.2555 µM 2.60754588080525 0.00503710860027767 no 98 0.00455969241628482 98 12779990 SGTC_119 0121-0043 24.815 µM 2.60258685655514 0.00510753256069655 no 99 0.00462616876858071 272 1092378 SGTC_1909 st060837 51.5 µM 2.59056056991277 0.0052819728440123 no 100 0.00479098788904342 145 678937 SGTC_1478 0453-0656 35.7 µM 2.58469744977291 0.00536892292613358 no 101 0.00487322402920584 76 5258496 SGTC_2373 9071805 200 µM 2.56846384884501 0.00561634306094446 no 102 0.00510751831679195 76 10149009 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.56826048567714 0.00561950574740775 no 103 0.00511051591913548 117 5355888 SGTC_2250 alverine citrate 130 µM 2.56352590283977 0.00569358598305126 no 104 0.0051807484523486 322 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1758 st042942 75.2445 µM 2.55531894988996 0.00582405280084083 no 105 0.00530452680165472 91 669317 SGTC_2921 7974240 10.71 µM 2.54742523598411 0.00595203549657837 no 106 0.00542605520479848 146 2979074 YDR527W RBA50 SGTC_1175 0741-0056 27.6 µM 2.51760936589366 0.00645823054959902 no 107 0.00590771407273302 124 765927 SGTC_2265 7929201 200 µM 2.51569524706549 0.00649199150357412 no 108 0.00593989279770203 118 1265108 SGTC_3140 9094243 49.47 µM 2.51539194884999 0.00649735533841445 no 109 0.00594500585857548 134 19291112 SGTC_995 3931-2021 34.6 µM 2.51323674441125 0.00653558319900377 no 110 0.00598145125110088 117 730143 SGTC_1098 clofazimine 15.1 µM 2.50832463369523 0.00662345580688798 no 111 0.0060652582040244 141 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2254 7938975 95.19 µM 2.50688582090939 0.00664939170293142 no 112 0.00609000246378312 163 2969277 SGTC_2383 9036125 200 µM 2.50188994472053 0.00674014526163433 no 113 0.00617661596481181 57 79580 SGTC_1148 3909-7663 27.7 µM 2.50018265522693 0.00677140934402166 no 114 0.00620646442097273 100 4084526 SGTC_3124 9127567 49.47 µM 2.49660638090062 0.00683731407960252 no 115 0.00626940263546664 99 17592030 SGTC_1770 st043884 66.3 µM 2.4958270033786 0.00685175166499483 no 116 0.00628319352595301 103 670149 SGTC_1144 3486-0183 12.5 µM 2.48100878189615 0.00713142154978334 no 117 0.00655055726498057 128 6744069 SGTC_539 4859-0462 2.54 µM 2.47746340826742 0.00719980953237365 no 118 0.00661599880230043 124 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1364 1653-0028 37.6 µM 2.47540705317666 0.00723973977666079 no 119 0.00665421987352719 127 5718652 SGTC_1166 k206-0078 225 µM 2.46259439347461 0.0074929630649572 no 120 0.00689679295648607 119 5404595 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.46162863897248 0.00751236224389064 no 121 0.00691538948208828 157 23665772 A membrane-active detergent. SGTC_141 0443-0274 32.331 µM 2.45658776962688 0.00761433834579437 no 122 0.00701317671891843 201 1627241 SGTC_1735 st034310 56.75 µM 2.44155796038338 0.0079256596601612 no 123 0.00731202031602651 132 871153 SGTC_1554 st069299 38.7 µM 2.44093898541569 0.00793871745574914 no 124 0.00732456477842053 124 24207999 SGTC_2016 5121758 140 µM 2.41829141904455 0.00842968022863068 no 125 0.00779679135743265 184 2795203 SGTC_334 1502-1024 68.5 µM 2.40344091800038 0.00876590317569899 no 126 0.00812079563850496 126 3296216 SGTC_3131 9127911 49.47 µM 2.38880283328638 0.00910876471002726 no 127 0.00845168555099712 138 45595681 SGTC_3010 9080089 71.4286 µM 2.38624335913261 0.00916990528439044 no 128 0.00851074157719968 125 17027233 SGTC_2702 st077768 96.8 µM 2.3850174806606 0.00919931602758697 no 129 0.00853915490990189 131 6484119 SGTC_1081 sertraline 6 µM 2.37815547969762 0.00936547556504251 no 130 0.0086997438471753 151 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1240 0356-0016 42.1 µM 2.36422459078742 0.00971089695881613 no 131 0.00903392781086946 150 4305613 SGTC_2707 st078556 66.6 µM 2.3527550047968 0.0100035931548348 no 132 0.00931745372480391 95 17250899 SGTC_2496 diffractaic acid 79.83 µM 2.34137251431328 0.0103016502290311 no 133 0.00960649317702023 159 94870 An apoptosis inducer which activates caspases. SGTC_1479 0549-0158 134 µM 2.34071745684733 0.0103190365030478 no 134 0.0096233632074562 169 5440202 SGTC_2650 prasterone 100 µM 2.33442613193206 0.0104873253752112 no 135 0.00978670989312679 68 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2156 5649887 115 µM 2.3342516885892 0.0104920255014642 no 136 0.00979127340467994 144 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2215 7188065 200 µM 2.32600865963115 0.01071622495374 no 137 0.0100090443586323 94 940217 SGTC_1833 st055984 71 µM 2.31103635319907 0.011134135978422 no 138 0.010415423498069 137 676288 SGTC_2832 7992762 51.95 µM 2.31013739942939 0.011159672766284 no 139 0.010440274233959 143 2985177 SGTC_1452 4194-0072 190 µM 2.30855385841039 0.0112047806643956 no 140 0.0104841754522973 152 1343545 SGTC_1903 st060211 78.3 µM 2.3003844671382 0.0114400163767468 no 141 0.0107132240206253 164 688960 SGTC_1021 4476-0760 85.3 µM 2.28836694384908 0.0117938521360582 no 142 0.0110580804987056 166 746768 SGTC_104 0074-0074 590.992 µM 2.28291400217917 0.0119575122001734 no 143 0.0112177172631745 74 3943124 SGTC_2753 fluvastatin 17.09 µM 2.27777487391846 0.0121135530178072 no 144 0.0113699970384111 171 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.27741463995717 0.0121245568087798 no 145 0.0113807383399071 147 165521 SGTC_2853 9015042 58.44 µM 2.26893209803646 0.0123861823647515 no 146 0.011636227713081 144 6457456 SGTC_284 0988-0104 32.6 µM 2.26838704525355 0.0124031592747503 no 147 0.0116528133326929 136 4666532 SGTC_1188 1403-0014 4.57 µM 2.26075451295307 0.0126430173085554 no 148 0.0118872313773723 231 9614867 SGTC_169 k015-0017 16.025 µM 2.25129826737774 0.0129457462588371 no 149 0.0121833262377433 124 1840002 SGTC_1695 st026914 34.495 µM 2.24471452315553 0.0131601989551469 no 150 0.0123932325511138 161 3289191 SGTC_2221 6807166 181.081 µM 2.23721011551307 0.0134083778147633 no 151 0.0126363052712559 75 674925 SGTC_2629 bisabolol 100 µM 2.23662236374724 0.013427984947239 no 152 0.0126555160033223 187 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2882 9058044 58.44 µM 2.23163376845802 0.0135954012957179 no 153 0.0128195889525929 142 18076804 SGTC_365 0121-0052 13.6 µM 2.22755102602367 0.013733754833579 no 154 0.0129552347832771 268 3101739 SGTC_1285 0929-0069 65.5 µM 2.2219451045142 0.0139257027288988 no 155 0.0131435078500608 168 1206237 SGTC_2001 4023502 57.655 µM 2.21820521871251 0.0140550396178792 no 156 0.0132704215402244 180 108941 YCR052W RSC6 SGTC_291 SEC14.278 35.5 µM 2.21204594454779 0.0142703032230114 no 157 0.0134817452632703 146 1068044 SGTC_1062 mesoridazine 14.2 µM 2.20836335987719 0.0144003594904144 no 158 0.0136094769032616 176 4078 A neuroleptic. SGTC_2397 5161689 200 µM 2.19455820968706 0.014897034030437 no 159 0.0140976520363364 193 2259942 SGTC_1454 4239-0054 42.6 µM 2.18993716939082 0.0150665452178692 no 160 0.0142643969227377 207 1340767 SGTC_3083 9117465 49.47 µM 2.18029885312134 0.015425443050346 no 161 0.0146176580170823 191 16420915 SGTC_1796 st049173 110.4 µM 2.1784031868182 0.0154968883659729 no 162 0.0146880164228205 116 94134 SGTC_2620 irigenin 100 µM 2.17127378554785 0.0157681351891249 no 163 0.0149552413378693 199 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.16531962280796 0.0159977794938961 no 164 0.0151816083229158 226 140250 A respiratory chain inhibitor. SGTC_2041 5107442 45.335 µM 2.16271446538043 0.0160991550998756 no 165 0.0152815739112305 206 793005 SGTC_1980 st071811 45.7 µM 2.16159190109258 0.0161430073479141 no 166 0.0153248231380352 163 4974850 SGTC_582 0987-0078 156 µM 2.15933267139073 0.016231573032353 no 167 0.0154121835996407 310 1625765 SGTC_467 ro 31-8220 72.8 µM 2.15564479220052 0.0163770384991597 no 168 0.0155557060613562 260 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2064 5220758 200 µM 2.14628170907279 0.0167513816810381 no 169 0.0159252549975377 214 788518 SGTC_741 4582-0002 126 µM 2.13327155421739 0.0172836730371781 no 170 0.0164512281460579 185 2912688 SGTC_862 0452-0056 10.2 µM 2.11790444895299 0.0179309451901482 no 171 0.0170915803787124 168 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2172 5754775 163.918 µM 2.10678280094617 0.0184121912268297 no 172 0.0175682055001481 206 2263357 SGTC_1070 indatraline 8.81 µM 2.0866625601181 0.0193107902302751 no 173 0.0184593239382205 195 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2192 5915882 198.485 µM 2.07796092860064 0.0197108111947352 no 174 0.0188564789685662 148 2876149 SGTC_2012 4023501 200 µM 2.07300568293058 0.0199417356680238 no 175 0.0190858753430773 203 3477460 SGTC_800 3448-7362 155 µM 2.06572581322711 0.0202851531667625 no 176 0.0194271882452195 487 15991913 SGTC_161 4065-0411 162.148 µM 2.05515694100168 0.0207926390424916 no 177 0.0199319242928278 286 1906281 YLR208W SEC13 SGTC_2589 lobaric acid 100 µM 2.02637284119037 0.0222295604536686 no 178 0.021363295950408 222 73157 A novel microtubule depolymerizer. SGTC_2809 7964133 12.99 µM 2.01972766584631 0.0225729427425383 no 179 0.0217058218764216 261 1253665 SGTC_2400 5203494 178.7 µM 2.0189502644513 0.0226134047700585 no 180 0.0217461945608825 205 6777674 SGTC_857 0438-0306 1.35 µM 1.99925154476351 0.0236592655389462 no 181 0.0227905720260515 195 4686136 SGTC_3189 9110682 49.47 µM 1.99669726604382 0.0237978127500021 no 182 0.0229290396559416 210 17122418 SGTC_305 1682-2595 20.8 µM 1.99434793695683 0.0239258447944612 no 183 0.0230570219590668 218 226033 SGTC_736 0958-0254 92.6 µM 1.98050323956632 0.0246921553126671 no 184 0.0238235048441575 254 6812352 SGTC_802 4112-3352 742 µM 1.97779343929926 0.0248445287215405 no 185 0.0239760069635359 242 704594 SGTC_1168 k815-0004 80.5 µM 1.97324110493084 0.0251022837023039 no 186 0.0242340496842526 204 642433 SGTC_735 3076-0345 636 µM 1.97114160888825 0.0252219111054504 no 187 0.0243538402866548 266 2888990 SGTC_2177 5811945 192 µM 1.96858674810707 0.0253681287961557 no 188 0.0245002827810526 223 5343475 SGTC_899 1083-0020 478 µM 1.96798458811873 0.0254026943313774 no 189 0.024534905512546 240 767123 SGTC_147 4466-0538 29.23 µM 1.96496831072033 0.0255764306844724 no 190 0.0247089526976242 255 6742687 YHR072W ERG7 SGTC_204 PMA1.184 62.41 µM 1.96291874343568 0.0256950517420356 no 191 0.0248278082425198 244 2252213 YGL008C PMA1 SGTC_2711 st079103 59.1 µM 1.9575880410336 0.02600573039475 no 192 0.0251391858796372 181 54693780 SGTC_2819 7996655 46.38 µM 1.95563210964142 0.0261205092248601 no 193 0.0252542537577375 198 6456960 SGTC_1512 0259-0544 12.2 µM 1.95353191751356 0.0262442249840348 no 194 0.0253782995351579 249 18476 SGTC_1961 st076550 68.7 µM 1.9523647115493 0.0263131929730159 no 195 0.02544745977813 200 1579337 SGTC_1268 0828-0275 2.46 µM 1.95045583011761 0.0264263116244238 no 196 0.0255609065302132 229 745337 SGTC_1840 st055363 71 µM 1.95033160666225 0.026433687060626 no 197 0.0255683039084375 193 676033 SGTC_2233 sulbentine 40.3845 µM 1.94865957855481 0.0265331267799159 no 198 0.0256680460094102 298 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_773 4358-1457 44.6 µM 1.94243775496632 0.0269059036792437 no 199 0.0260420642156312 292 1186886 SGTC_3133 9127736 49.47 µM 1.93075287446394 0.0276178146099647 no 200 0.0267568103533829 227 27243420 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.92881223004473 0.02773755698524 no 201 0.0268770884960811 232 66535 A nucleotide analog. SGTC_3105 9121040 49.47 µM 1.92416471510145 0.0280260791872567 no 202 0.0271669702006249 99 41448907 SGTC_2592 piperlongumine 83.33 µM 1.92401696600877 0.0280352924299212 no 203 0.0271762284428231 250 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2484 5809818 12.04 µM 1.92021580228692 0.0282731914708304 no 204 0.0274153231967518 232 2870548 SGTC_534 k292-0788 63.4 µM 1.91906024764372 0.0283458450070414 no 205 0.0274883547994394 270 4146317 SGTC_503 tyrphostin 8 294 µM 1.91770661959369 0.0284311496035998 no 206 0.0275741109562836 262 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1162 k048-0130 20.1 µM 1.91639173901722 0.0285142167731318 no 207 0.0276576257683115 232 6797406 SGTC_427 1354-0053 47.3 µM 1.91555202356637 0.0285673710997694 no 208 0.0277110706303192 261 6813657 SGTC_1335 1486-0900 202 µM 1.91467771847286 0.0286228025212174 no 209 0.0277668084251265 289 X1335 SGTC_157 1348-1695 65.819 µM 1.90954056842939 0.0289503104591945 no 210 0.0280961967711413 345 5380510 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.90614670718098 0.0291683826497719 no 211 0.0283155871344863 246 6708760 SGTC_2517 totarol 10 µM 1.89776691413665 0.0297126750272567 no 212 0.0288633967266582 240 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1365 1672-3266 55.4 µM 1.89612895553624 0.0298200439244448 no 213 0.0289714972983468 257 6415873 SGTC_1969 st069479 40.1 µM 1.89002498820925 0.0302230000252574 no 214 0.0293773090910621 200 3895485 SGTC_596 1155-0152 116 µM 1.88485521342779 0.0305678054120159 no 215 0.0297246940848892 324 280313 SGTC_1284 0929-0043 16 µM 1.8694844294947 0.0316122733356407 no 216 0.0307777239575583 273 1239883 SGTC_2723 salbutamol 83.58 µM 1.86477220759138 0.0319383215542521 no 217 0.0311066702542572 143 9884233 β2-adrenoceptor agonist SGTC_947 3447-0010 211 µM 1.8647673896936 0.0319386563302717 no 218 0.0311070080600771 242 748350 SGTC_581 0958-0271 211 µM 1.86097708691276 0.0322029283994845 no 219 0.0313737062493214 346 4591145 SGTC_1625 st003711 30.1 µM 1.8597038753516 0.0322921047654443 no 220 0.0314637167246328 269 24207034 YER133W GLC7 SGTC_138 0850-0259 40.9225 µM 1.85308101630253 0.0327592661374574 no 221 0.0319353736730746 483 6813004 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.84898288189619 0.0330511199073378 no 222 0.0322301422762964 270 6708514 SGTC_383 2324-0395 7.37 µM 1.84737527002938 0.0331661915421823 no 223 0.0323463853919768 290 3146421 SGTC_1812 st052057 4.327 µM 1.84346552318491 0.0334474261062476 no 224 0.0326305355102778 278 3645418 SGTC_168 3970-0862 530.542 µM 1.84142846991058 0.0335947309277076 no 225 0.032779396956543 503 3135186 SGTC_1570 verbenone 133 µM 1.83236363666354 0.0342567221468029 no 226 0.0334486309519955 262 29025 A natural terpanoid with antifungal properties. SGTC_3235 9132602 49.47 µM 1.83172364233145 0.0343038623867183 no 227 0.0334963022204863 295 4912240 SGTC_545 4218-0007 221 µM 1.8305323544486 0.0343917513880297 no 228 0.0335851866506197 267 2840508 SGTC_1986 st071812 45 µM 1.82997531130038 0.0344329115031197 no 229 0.0336268153431218 216 11838594 SGTC_166 k072-0058 166.424 µM 1.82512138017457 0.0347932858259226 no 230 0.0339913572380462 291 5846229 SGTC_1511 0906-3109 28.5 µM 1.81835077718486 0.0353011279780237 no 231 0.0345052682671293 389 2882180 SGTC_602 3130-1533 38.1 µM 1.81628613220154 0.0354571948791247 no 232 0.0346632457110121 314 720941 SGTC_2704 st078022 71.1 µM 1.81544779835401 0.0355207259809375 no 233 0.0347275606234131 266 54697681 SGTC_1319 1306-0155 43.7 µM 1.8079559674862 0.0360926297221047 no 234 0.0353066769901287 324 3122360 SGTC_2862 9027634 71.43 µM 1.80306481177567 0.0364700582324927 no 235 0.0356890183156965 280 5012562 SGTC_614 0462-0418 107 µM 1.80236313813075 0.0365244671874643 no 236 0.0357441453963787 277 5188303 SGTC_3255 9139072 49.47 µM 1.80130139464002 0.0366069228305272 no 237 0.0358276940761029 268 17646060 SGTC_192 3455-0609 60.9 µM 1.7949348585485 0.0371045516003508 no 238 0.0363320396299166 273 3769639 SGTC_324 1315-0088 19.6 µM 1.78514896604347 0.0378802159179457 no 239 0.0371185786435337 223 6787421 SGTC_1057 3448-5381 134 µM 1.77460488142575 0.0387307341751631 no 240 0.0379815753370333 317 5497911 SGTC_1540 guanosine 70.6 µM 1.7741301305694 0.0387693920990164 no 241 0.0380208139629738 252 6802 Guanosine is a purine nucleoside SGTC_2933 9026794 32.47 µM 1.77059148139519 0.0390585278072726 no 242 0.0383143297758713 331 17586027 SGTC_2256 7954252 200 µM 1.77053903845379 0.0390628259768045 no 243 0.0383186935466678 218 2972920 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.76941985995415 0.039154644526708 no 244 0.0384119168909544 333 6708561 SGTC_3240 9133527 49.47 µM 1.76763734010117 0.0393012469284317 no 245 0.0385607757100432 266 17617455 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.76585340511357 0.0394484126044903 no 246 0.0387102230385132 285 75037 A free radical scavenger. SGTC_1137 ixabepilone 100 µM 1.76441998886572 0.0395669867996979 no 247 0.0388306476260048 336 154225 A novel microtubule stabilizer. SGTC_2015 5119600 184 µM 1.75949416794823 0.0399766689360995 no 248 0.0392468049805271 310 2828786 SGTC_1108 betulinic acid 729.144 nM 1.75507383494844 0.040347238010278 no 249 0.0396233395825399 289 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_944 3370-0224 231 µM 1.74968084910574 0.0408031199496172 no 250 0.0400867000377166 298 4580514 SGTC_1635 st007035 42.4 µM 1.74824126892176 0.0409255152446529 no 251 0.0402111291360973 550 3716403 SGTC_356 1634-0012 32.5 µM 1.74022954791722 0.0416121351610841 no 252 0.040909359598069 336 735457 SGTC_523 1934-0222 13.7 µM 1.73845058513412 0.0417658548688692 no 253 0.0410657249967646 331 1361595 SGTC_2369 9071472 200 µM 1.73295576749227 0.0422435666204419 no 254 0.0415517654807278 322 17296037 SGTC_2834 9001755 58.44 µM 1.72850112704558 0.0426340833935711 no 255 0.0419492095692517 300 2989575 SGTC_3001 9076041 71.4286 µM 1.7282908767588 0.0426525869111589 no 256 0.0419680439462462 283 16004211 SGTC_2747 doxorubicin 7.63 µM 1.72630267684858 0.0428278837934555 no 257 0.0421464870236994 171 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1887 st057648 70.8 µM 1.72226004306364 0.0431861129071808 no 258 0.0425112112019086 303 688672 SGTC_430 0958-0115 16.4 µM 1.71933257798552 0.0434470315211009 no 259 0.0427769155885616 331 6833180 SGTC_2380 9035439 200 µM 1.71306208852468 0.0440101890103076 no 260 0.0433505588486383 354 6462575 SGTC_1036 k216-0215 33.5 µM 1.71214077459627 0.0440934267035055 no 261 0.043435364360384 394 622330 SGTC_2598 perillyl alcohol 100 µM 1.70569063985515 0.0446797360710504 no 262 0.0440328466534141 340 10819 An apoptosis inducer. SGTC_84 0443-0269 128.823 µM 1.69552527900299 0.0456164842577958 no 263 0.0449879094771157 341 6150058 SGTC_2982 9019404 25.97 µM 1.6919591248942 0.0459488261243742 no 264 0.0453268837276421 303 22333232 SGTC_1882 5615643 20 µM 1.69068212407504 0.0460683060981493 no 265 0.0454487651182039 284 2253075 SGTC_928 2764-0428 58.7 µM 1.68989051729523 0.0461424963853665 no 266 0.0455244510552277 368 662578 SGTC_1461 k072-0203 53.8 µM 1.68939023499681 0.0461894328767064 no 267 0.0455723355485479 318 5418714 SGTC_2972 9093619 59.92 µM 1.68789708355934 0.0463297483942871 no 268 0.0457154932970794 319 25236256 SGTC_949 1165-0505 146 µM 1.68680006298646 0.0464330563365798 no 269 0.0458209016802239 367 6244267 SGTC_730 1436-0052 41.2 µM 1.68679419206486 0.04643360970642 no 270 0.0458214663189449 276 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2800 7887935 81.82 µM 1.68249014632686 0.0468407187053502 no 271 0.046236917035562 322 2961002 SGTC_2661 dactinomycin 12.96 µM 1.67926006635661 0.047148120547331 no 272 0.0465506850399359 360 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2201 6605497 169.863 µM 1.67449424193649 0.0476046280229275 no 273 0.047016752553903 288 670741 SGTC_270 tamoxifen 5.46 µM 1.67005212759375 0.0480333093821451 no 274 0.0474545252806481 375 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3223 9129970 49.47 µM 1.66925194940505 0.0481108570875494 no 275 0.0475337292953646 358 17248386 SGTC_2817 7995342 71.43 µM 1.66367098794826 0.0486545148931019 no 276 0.0480890985434674 292 18879975 SGTC_2361 9034121 116 µM 1.65867266924409 0.0491455742955068 no 277 0.0485908848034045 331 6496917 SGTC_1743 st037606 46.3785 µM 1.6556706573638 0.0494424042221075 no 278 0.0488942663161091 361 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3254 9136651 49.47 µM 1.64867582546546 0.0501395849562895 no 279 0.049607032645753 372 16454030 SGTC_2845 9003024 42.97 µM 1.64859813110334 0.0501473726009593 no 280 0.04961499593566 382 2990173 SGTC_629 3448-6466 76.7 µM 1.64152902530498 0.0508599844404636 no 281 0.0503438235270443 390 573744 SGTC_1004 4084-0029 199 µM 1.64123504530311 0.0508897932554821 no 282 0.0503743167885255 373 716894 YLR208W SEC13 SGTC_2791 5663188 71.43 µM 1.63795979514333 0.0512228366874053 no 283 0.0507150404940138 340 54690634 SGTC_1068 loratadine 26.9 µM 1.63308081095225 0.0517221687432643 no 284 0.0512260009066627 342 3957 A H1 histamine antagonist. SGTC_2357 9067248 200 µM 1.63094449312666 0.0519420213678599 no 285 0.0514510161433837 333 9150235 SGTC_98 0074-0023 107.663 µM 1.62947794816501 0.0520933757359243 no 286 0.0516059397059395 380 3563821 SGTC_882 0843-0131 351 µM 1.62702579225478 0.052347232229705 no 287 0.0518658100120816 376 5425421 SGTC_1374 2889-5571 141 µM 1.61775497700926 0.0533158694887123 no 288 0.0528577063769028 426 2853281 SGTC_1913 st060213 96.1 µM 1.61046272673102 0.0540877190458886 no 289 0.0536484381315376 405 688959 SGTC_2340 7987427 183.45 µM 1.60911150512697 0.0542317058030125 no 290 0.0537959809845839 354 2239331 SGTC_3282 9108498 15.4605 µM 1.60845753574156 0.0543015018976713 no 291 0.0538675046383983 386 16459645 SGTC_2950 9072895 21.46 µM 1.60594758640185 0.0545700409274716 no 292 0.0541427133317377 420 17332245 SGTC_625 k213-0058 121 µM 1.60063364464484 0.0551420434214986 no 293 0.0547290429275882 561 3655420 SGTC_872 0588-0139 234 µM 1.59864413469196 0.0553574126107312 no 294 0.0549498486140056 399 2047100 SGTC_2815 7968870 71.43 µM 1.59660702857834 0.0555786219137183 no 295 0.0551766656069012 419 2977326 YHR190W ERG9 SGTC_559 1550-0661 158 µM 1.5952286378788 0.0557286967063152 no 296 0.0553305584693553 353 5830875 SGTC_253 dyclonine 31.25 µM 1.59415938209776 0.0558453339760087 no 297 0.0554501707122092 417 3180 An oral anasthetic. SGTC_1463 k081-0032 34.1 µM 1.59283449454199 0.0559901233169293 no 298 0.0555986622845036 280 977755 SGTC_1473 k844-0725 134 µM 1.59152112062155 0.0561339464858474 no 299 0.0557461730424986 411 54682906 SGTC_2234 tolnaftate 200 µM 1.58660713817335 0.056674645794602 no 300 0.056300824869906 273 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3065 9113888 49.47 µM 1.580607527658 0.0573403530954208 no 301 0.0569839017856415 344 16648368 SGTC_665 3914-0008 307 µM 1.57417334429095 0.0580611011436545 no 302 0.0577236899990378 389 1069549 SGTC_3029 9088683 49.47 µM 1.57354006870667 0.0581324229025902 no 303 0.0577969089818067 360 25236615 SGTC_1689 st020265 53.493 µM 1.57266737462157 0.0582308216033906 no 304 0.0578979290235724 355 5758320 YPR016C TIF6 SGTC_1723 st034307 2.5525 µM 1.57209355788485 0.0582955923157311 no 305 0.0579644276567008 379 867466 SGTC_288 1315-0019 35.1 µM 1.5688217148209 0.0586659900482387 no 306 0.0583447435708201 388 6811474 SGTC_127 0180-0333 59.125 µM 1.56804414483455 0.0587542880534654 no 307 0.0584354151746811 486 771601 SGTC_782 0083-0095 30.5 µM 1.5680371987413 0.0587550772962062 no 308 0.0584362256495632 433 3591729 An indicator and reagent. SGTC_1973 st070275 50.2 µM 1.56752127896851 0.0588137214174154 no 309 0.0584964482007365 350 17118334 SGTC_3356 9151811 4.48 µM 1.56668782871491 0.0589085559645839 no 310 0.0585938385560441 378 1859254 YPR165W RHO1 SGTC_1278 0874-0585 172 µM 1.56661820891424 0.0589164831146013 no 311 0.0586019795285533 364 766306 SGTC_206 4546-0025 72.014 µM 1.56523786006183 0.0590738272574329 no 312 0.0587635736576025 464 6620745 YIL048W NEO1 SGTC_641 4092-0595 30 µM 1.56411247369904 0.0592023523169301 no 313 0.0588955785576628 392 786260 SGTC_1415 3966-0071 78.1 µM 1.55880625248084 0.059811307626072 no 314 0.0595211219555458 372 2893185 SGTC_1049 3226-0134 66 µM 1.55274998292077 0.0605123246192858 no 315 0.0602414380726709 434 5702385 SGTC_3166 9102297 49.47 µM 1.54421749205434 0.0615108541516908 no 316 0.0612678263321276 425 25237072 SGTC_2785 7756463 72.73 µM 1.53879183871984 0.0621524637396866 no 317 0.0619275614643242 389 2201551 SGTC_2513 baicalein 25.65 µM 1.53513742039748 0.0625875505977898 no 318 0.0623750380896114 391 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_600 1495-0418 41.6 µM 1.53470062195728 0.0626397133004094 no 319 0.0624286915051426 383 5377768 SGTC_1414 3917-0015 5.4 µM 1.53468390380499 0.0626417104641591 no 320 0.0624307457665857 355 6618702 SGTC_830 4076-0286 57.8 µM 1.53459224476458 0.0626526610079303 no 321 0.0624420094091656 583 6866659 SGTC_311 1315-0136 58 µM 1.53367538234872 0.0627622810679595 no 322 0.0625547664766304 381 6759207 SGTC_3164 9100705 49.47 µM 1.53109505066975 0.0630715877705832 no 323 0.0628729514345318 322 17174235 SGTC_2856 9022925 19.48 µM 1.52087989384291 0.0643077536995174 no 324 0.0641449902013789 416 4944862 SGTC_3290 9121031 71.43 µM 1.51782035433511 0.064681638546444 no 325 0.0645298462148363 357 17014854 SGTC_2214 7179297 48.276 µM 1.51448839986801 0.0650907313405518 no 326 0.0649510068671391 349 769744 SGTC_2973 9094665 17.96 µM 1.51220186306972 0.0653726290150856 no 327 0.0652412586145952 470 25237061 YIL048W NEO1 SGTC_3045 9092950 49.47 µM 1.51179165032731 0.065423302487372 no 328 0.0652934371018669 440 44120432 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.50632259583386 0.0661018075807965 no 329 0.0659921901492119 461 688664 SGTC_1020 4335-0961 93.3 µM 1.5045893893369 0.0663179674075062 no 330 0.066214837958152 391 669075 SGTC_1881 5652484 16 µM 1.49970496279913 0.0669300823769906 no 331 0.0668454222340238 444 2255129 SGTC_1557 sumaresinolic acid 42.3 µM 1.48805194515702 0.0684080817703879 no 332 0.0683685975651238 415 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1440 4100-1550 40 µM 1.48609612365219 0.0686585958295176 no 333 0.0686268487404746 356 742806 SGTC_977 1348-1378 135 µM 1.48462727487943 0.0688472000714787 no 334 0.0688212931114203 429 X977 SGTC_295 k015-0027 31 µM 1.4829339376848 0.0690651246241439 no 335 0.0690459817687537 401 3887424 SGTC_85 0868-0259 160.055 µM 1.47973805052401 0.0694778682743183 no 336 0.0694715834171963 401 83173 SGTC_965 1291-5240 308 µM 1.47834503863054 0.0696583668407666 no 337 0.0696577241711645 450 2834598 SGTC_3308 9128332 17.569 µM 1.47400463781678 0.0702230865086916 no 338 0.0702401712281794 540 17332805 YDL196W YDL196W SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.46797332103132 0.0710136448595356 no 339 0.0710557349686678 483 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2283 7944793 200 µM 1.46779459086832 0.0710371758744985 no 340 0.071080013610174 460 2970533 SGTC_1886 st057356 49.9 µM 1.46584341351922 0.0712944510213368 no 341 0.0713454753953455 412 24207747 SGTC_456 gingerol 170 µM 1.46295817660922 0.0716761979363271 no 342 0.0717394117315051 436 442793 A herb. SGTC_2166 5933061 31.504 µM 1.46158374857623 0.0718585996061714 no 343 0.0719276552281905 442 2877375 SGTC_1078 idebenone 36.1 µM 1.46121658794191 0.0719073860458668 no 344 0.0719780060879786 509 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1102 cgs 12066b 26.1 µM 1.45980718881385 0.0720948957462474 no 345 0.0721715361413065 405 6438352 A 5-HT1B full agonist. SGTC_358 0075-0058 9.45 µM 1.45902400301061 0.0721992544773461 no 346 0.0722792506748035 567 1069125 SGTC_3307 9126885 69.2785 µM 1.45730463705261 0.0724287643345185 no 347 0.0725161537012262 488 24824909 SGTC_2686 alizarin 95.37 µM 1.45565224469488 0.0726498605269987 no 348 0.0727443888154948 422 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.45170156230254 0.0731805713288807 no 349 0.0732923023667784 487 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1654 st012436 41.8 µM 1.45011161019213 0.0733949910835941 no 350 0.0735136989965293 392 4323132 SGTC_1002 4049-0206 172 µM 1.4474242367773 0.0737585002652259 no 351 0.0738890708407586 510 4662749 SGTC_1246 0422-0085 105 µM 1.44230817361521 0.0744543290667808 no 352 0.0746077276924838 499 264295 SGTC_2576 guaiol 23.12 µM 1.44063343201555 0.0746831938207606 no 353 0.0748441351233704 483 227829 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.43905580985751 0.0748992772445812 no 354 0.0750673554601649 472 688751 SGTC_21 0849-0113 22.993 µM 1.43637225228156 0.0752679333539898 no 355 0.0754482222253653 477 1560156 SGTC_3184 9108758 49.47 µM 1.43442590780026 0.075536178477094 no 356 0.0757253793665277 419 902885 SGTC_726 3448-4391 34.2 µM 1.42827629583357 0.0763885053593824 no 357 0.0766061739140307 501 1356692 SGTC_1645 Cervolide 78 µM 1.42723248981949 0.0765338988898412 no 358 0.0767564462395809 426 23173 A fragrance. SGTC_2664 lyso-paf C-16 73.48 µM 1.42591897136491 0.0767171601301644 no 359 0.0769458662908784 476 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.42554976916626 0.0767687310113264 no 360 0.0769991721729631 396 17037758 SGTC_657 3534-0529 86.7 µM 1.42264766520037 0.0771750208653871 no 361 0.0774191594877059 460 1049549 SGTC_1565 sinapyl alcohol 95.1 µM 1.41789857225835 0.0778434076020099 no 362 0.0781101896520614 452 5280507 A phenol propionate derived from cinnamic acid. SGTC_3354 9151612 71.43 µM 1.41757592395056 0.0778889759639031 no 363 0.0781573067014592 499 27261949 SGTC_640 3381-0960 37.1 µM 1.41319304578906 0.0785099866981608 no 364 0.0787994853616669 483 1745025 SGTC_1955 wogonin 32.4 µM 1.41282645948579 0.0785620979856024 no 365 0.078853378176582 446 5281703 A flavanone. SGTC_1850 st056238 17 µM 1.41257106891243 0.078598417975558 no 366 0.0788909403156697 527 5393177 SGTC_55 0767-0285 6.563 µM 1.40725098153764 0.0793579031359864 no 367 0.0796764895135315 527 3116166 SGTC_123 0083-0120 66.675 µM 1.40306907880542 0.0799587926576256 no 368 0.0802981203728015 494 16001701 SGTC_2954 9074818 52.69 µM 1.40165783008737 0.0801623467529169 no 369 0.0805087244848502 468 16648742 SGTC_2089 5281248 129.67 µM 1.40147976932223 0.0801880574833729 no 370 0.0805353265483292 484 2737878 SGTC_3253 9135987 49.47 µM 1.39955457703901 0.0804664399306572 no 371 0.0808233720812923 418 4182430 SGTC_1487 3970-0795 2.82 µM 1.39875535776721 0.0805822211196685 no 372 0.0809431787706437 491 3765103 SGTC_1293 1000-1278 195 µM 1.39142187517112 0.0816504881546091 no 373 0.0820487675021902 499 678847 SGTC_3 0833-0587 95.581 µM 1.39101444675071 0.0817101497584891 no 374 0.0821105229842199 471 5382644 SGTC_920 mycophenolic acid 780.421 nM 1.38945611933714 0.081938646008411 no 375 0.0823470477320237 491 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3221 9128209 49.47 µM 1.3876854395957 0.0821988633172628 no 376 0.0826164258322649 445 16460723 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.38746689944613 0.0822310228612338 no 377 0.0826497188402357 474 521171 SGTC_2645 abamectin 100 µM 1.38536223349008 0.082541222807504 no 378 0.082970866496183 489 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_186 3455-3465 67.277 µM 1.38517669224707 0.0825686113275601 no 379 0.0829992229008088 360 755278 SGTC_1458 k015-0034 6.33 µM 1.3847218923874 0.0826357751742408 no 380 0.0830687611296692 459 3598957 SGTC_745 0469-0705 296 µM 1.38199851395822 0.0830388182973216 no 381 0.083486078695784 559 3486736 SGTC_574 1315-0397 40 µM 1.38023294061236 0.0833009010462253 no 382 0.0837574673704033 571 6794277 SGTC_180 1486-1293 102.781 µM 1.37429177108772 0.0841873791438722 no 383 0.0846755599823836 482 4140536 SGTC_710 3448-4187 58 µM 1.37017163260979 0.0848062878853387 no 384 0.0853166656058304 605 3946412 SGTC_1621 st003705 32.4 µM 1.36842313634361 0.0850699678671974 no 385 0.0855898331537969 538 24207032 SGTC_2870 9038528 12.99 µM 1.3633839026197 0.0858333406342241 no 386 0.086380775818919 450 6463316 SGTC_1270 0831-1170 17.3 µM 1.35895159628684 0.0865090004308656 no 387 0.087080963691355 559 6764716 SGTC_1063 disulfiram 1.84 µM 1.35501312033482 0.0871127102271674 no 388 0.087706688432317 499 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_901 1112-0062 60.1 µM 1.35495685260873 0.0871213579713104 no 389 0.0877156521981445 479 1908457 SGTC_1975 st070967 30.8 µM 1.35000620744457 0.0878847309095423 no 390 0.0885069958709586 558 261391 SGTC_974 1326-0144 138 µM 1.34629801611369 0.0884597812750742 no 391 0.0891032126962775 534 5411856 SGTC_3292 9120825 59.784 µM 1.34577747485511 0.0885407284505509 no 392 0.0891871459447538 507 24824900 SGTC_220 paclitaxel 373.376 µM 1.34479240026846 0.0886940642424756 no 393 0.0893461425861515 450 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2026 5148700 152 µM 1.34388034604607 0.0888362099955138 no 394 0.0894935412323781 535 79838 SGTC_931 2812-0076 566 µM 1.33604061685763 0.0900650517951454 no 395 0.090767998925635 542 3450959 SGTC_482 fipronil 114 µM 1.33556325908042 0.0901402813445453 no 396 0.0908460329024681 438 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1776 st049249 45.9 µM 1.33314903298256 0.0905214682491853 no 397 0.0912414505542068 544 1822314 SGTC_117 lucigenin 22.078 µM 1.33205405245851 0.0906947508274892 no 398 0.0914212136636635 581 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2595 hexamethylquercetagetin 100 µM 1.33137626997324 0.0908021343744207 no 399 0.0915326167758983 505 386331 SGTC_233 rapamycin 362 pM 1.32998926377112 0.0910221768445243 no 400 0.0917609043461983 518 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3033 9090887 49.47 µM 1.32823035683801 0.0913017882493656 no 401 0.0920510093547932 556 19325384 SGTC_1155 4088-0394 48.2 µM 1.32733750943777 0.0914439666088071 no 402 0.0921985305832959 533 2326248 SGTC_2652 actinonin 100 µM 1.3272200008329 0.0914626910691032 no 403 0.0922179590351907 480 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2047 4141938 200 µM 1.32407195841333 0.0919653756518533 no 404 0.0927395737558842 465 3807862 SGTC_3088 9117578 49.47 µM 1.32080007049885 0.0924900013117105 no 405 0.0932840181072615 505 678341 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.31867334714258 0.0928321927590054 no 406 0.0936391704600281 518 688662 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.31701156592757 0.0931002254862402 no 407 0.0939173738621898 592 4174840 SGTC_3273 9137859 49.47 µM 1.31696840464744 0.0931071946865891 no 408 0.0939246077306957 475 2377234 SGTC_218 alverine citrate 93.75 µM 1.31513094927924 0.093404244120467 no 409 0.0942329483673558 499 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2296 7971656 126.45 µM 1.31004820614912 0.0942295837726326 no 410 0.0950897641387169 543 666570 SGTC_3320 9137005 35.139 µM 1.30693468790722 0.0947378090317751 no 411 0.0956174469960413 514 4908713 SGTC_34 0469-0683 81.75 µM 1.30642208705863 0.0948216751103608 no 412 0.0957045293910714 526 3690923 SGTC_2706 st078239 82.5 µM 1.30613211375281 0.094869141553864 no 413 0.0957538168865558 536 15434492 SGTC_1424 4048-1941 275 µM 1.3036223655921 0.0952807000967311 no 414 0.0961811855574632 586 X1424 SGTC_1824 st053723 68.6 µM 1.29876657725292 0.0960807010583998 no 415 0.0970120240026316 538 675225 SGTC_1867 st057372 64 µM 1.2984395537498 0.0961347558130934 no 416 0.0970681673700862 554 688837 SGTC_742 0kpi-0133 140 µM 1.29682843310524 0.0964013894926315 no 417 0.0973451126160585 571 2728852 SGTC_3090 9117696 49.47 µM 1.29192441599318 0.0972163276022971 no 418 0.0981916606519152 513 7923821 SGTC_492 tmb-8 126 µM 1.28978567594329 0.0975733172302656 no 419 0.0985625413312487 379 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_684 1140-0066 328 µM 1.28942517820051 0.0976335845749086 no 420 0.0986251564076985 619 6813534 SGTC_808 0711-0032 135 µM 1.28642455512741 0.0981362826139362 no 421 0.0991474666367949 538 4252555 SGTC_3017 9080681 49.47 µM 1.28341819685105 0.0986418405435104 no 422 0.0996728010256633 530 16451914 SGTC_2310 7668677 200 µM 1.27988973450079 0.0992376255890652 no 423 0.100291959227498 556 2197143 SGTC_1089 terbinafine 2.25 µM 1.27744692951223 0.099651634728794 no 424 0.100722252719987 541 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1288 0973-0013 65.5 µM 1.27687157830029 0.0997493292187479 no 425 0.10082379489741 585 4315430 SGTC_2306 7482397 179.52 µM 1.27309120769535 0.100392975868814 no 426 0.101492839273903 571 891448 SGTC_350 k064-0020 19.8 µM 1.27102921009757 0.100745326818176 no 427 0.101859128584902 609 2790705 SGTC_1848 st056003 16.4 µM 1.27011827317154 0.10090127319917 no 428 0.102021251750925 599 146492 SGTC_3035 9091303 49.47 µM 1.26727785846399 0.10138866326694 no 429 0.102527977346212 533 25237002 SGTC_2725 haloperidol 53.21 µM 1.26678297260579 0.101473756446093 no 430 0.102616451068314 569 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_351 caspofungin 25 nM 1.26299729865413 0.102126405749044 no 431 0.103295075263328 714 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1738 st035555 74 µM 1.26194522203203 0.102308324618543 no 432 0.10348424900822 578 5331140 SGTC_3332 9141069 11.198 µM 1.25820416209461 0.102957115494979 no 433 0.104158965068378 509 17332883 SGTC_26 0302-0163 425.158 µM 1.25446413402847 0.103608709923239 no 434 0.104836677091322 567 3100915 SGTC_2654 protoveratrine a 100 µM 1.25303599432337 0.103858310837883 no 435 0.105096303802856 568 5702278 A heart drug and vasodilator. SGTC_744 1594-0068 283 µM 1.25064748562071 0.104276732938242 no 436 0.105531558864135 643 668392 SGTC_512 prima-1 270 µM 1.24596741278658 0.105100133950911 no 437 0.106388179524615 612 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1093 fluphenazine 7.97 µM 1.24513884293202 0.105246399531842 no 438 0.106540359114106 615 6602611 An atypical antipsychotic. SGTC_1750 st081859 2.357 µM 1.2447869451137 0.105308563804123 no 439 0.106605038077666 767 5291695 SGTC_3198 9112019 49.47 µM 1.24448376537898 0.105362143114768 no 440 0.106660785362056 565 45595555 SGTC_1223 0764-0573 147 µM 1.24036379205869 0.106092199295897 no 441 0.107420433534405 622 1609797 SGTC_1920 st075728 45.7 µM 1.23934217517179 0.106273793186001 no 442 0.107609403032087 578 3400306 SGTC_3053 9095903 49.47 µM 1.23397977177663 0.107230650459728 no 443 0.108605220989834 577 17174018 SGTC_791 1348-1292 225 µM 1.23108521861795 0.107749723286215 no 444 0.109145496655312 686 5437054 SGTC_1014 4130-3005 69.3 µM 1.23069675767753 0.107819522519569 no 445 0.109218150607069 613 743608 SGTC_144 4161-2749 112.381 µM 1.2283455630069 0.108242683800539 no 446 0.109658636883887 519 797501 YMR168C CEP3 SGTC_532 1548-0774 215 µM 1.22640738254781 0.108592409750092 no 447 0.11002270462321 631 5932993 SGTC_2018 5133068 143 µM 1.22640629493365 0.108592606227471 no 448 0.110022909163778 573 785362 SGTC_1337 1486-1011 40.3 µM 1.21973812627071 0.109802021140612 no 449 0.111282081750845 581 X1337 SGTC_1314 1222-0010 41.1 µM 1.21804423181758 0.110110779155896 no 450 0.111603582295782 592 3526027 SGTC_1897 st060201 15 µM 1.21753925649327 0.11020294494743 no 451 0.111699554889747 570 611878 SGTC_363 0455-0021 3.06 µM 1.2171795773745 0.110268625672072 no 452 0.111767949347314 627 4597466 SGTC_714 4296-0578 26.1 µM 1.2167700742361 0.110343438893618 no 453 0.111845854506115 534 1589775 SGTC_1227 3909-8010 46.6 µM 1.21600166200163 0.110483920389805 no 454 0.111992144445889 582 15982272 SGTC_177 1327-0068 8.361 µM 1.21085658322145 0.111427850331545 no 455 0.112975187413808 626 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_345 1362-0200 395 µM 1.21039988158389 0.111511916100755 no 456 0.113062743661545 580 1419823 SGTC_2783 7738165 71.43 µM 1.20968503233435 0.111643590595083 no 457 0.113199887704718 506 17201110 SGTC_411 enrofloxacin 100 µM 1.20891203250639 0.111786101502936 no 458 0.113348321470056 598 71188 A bacterial gyrase inhibitor. SGTC_1682 st012968 530 nM 1.2088506933578 0.111797415610177 no 459 0.113360105941323 565 24207270 SGTC_921 1561-0023 372 µM 1.20740714893357 0.112063916242015 no 460 0.113637691869302 625 24050882 SGTC_1591 genipin 88.4 µM 1.20541076514491 0.112433227478113 no 461 0.114022383853828 580 442424 A DNA cross-linking agent. SGTC_734 2023-0417 80 µM 1.20247142710248 0.112978557175958 no 462 0.114590464974425 621 3935732 SGTC_327 1273-0057 3.96 µM 1.20035105584338 0.113373115924537 no 463 0.115001514430705 582 3108138 SGTC_2519 cryptotanshinone 88.04 µM 1.19856463560214 0.113706295065259 no 464 0.115348638059172 605 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_694 1315-0438 43.2 µM 1.19819239669476 0.113775807852011 no 465 0.115421062354044 530 6793154 SGTC_1298 1079-1278 263 µM 1.19723313074706 0.113955083059572 no 466 0.115607849909774 658 2840950 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.19481412168567 0.114408060077163 no 467 0.116079830834495 663 688801 SGTC_1820 st053765 18.6 µM 1.1924527361572 0.114851481706532 no 468 0.11654188632734 597 3690829 SGTC_780 0109-0199 192 µM 1.18911196722502 0.115480898426431 no 469 0.117197804887606 676 610414 SGTC_648 0375-0473 33.3 µM 1.18825418097267 0.11564290414546 no 470 0.117366641709818 662 1713139 SGTC_3020 9089140 49.47 µM 1.18703564409125 0.115873320469321 no 471 0.117606780587635 604 17217859 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.18514742616044 0.116231012175265 no 472 0.11797958120241 693 1273210 SGTC_1171 0368-0077 21.4 µM 1.18458831669973 0.116337076425853 no 473 0.118090129311755 595 3239779 SGTC_2750 bromebric acid 70.15 µM 1.18429471239972 0.116392801274177 no 474 0.118148210600532 689 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.17856170335371 0.117484698579606 no 475 0.119286374370192 647 4213774 SGTC_2766 oltipraz 83.91 µM 1.17636227612935 0.117905515944608 no 476 0.11972506981684 620 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1663 st014140 55.4 µM 1.17626944826291 0.117923300164968 no 477 0.119743610155801 735 4207120 SGTC_477 mead ethanolamide 10 µM 1.17456070012708 0.11825100591592 no 478 0.120085256975312 471 16061185 SGTC_772 k072-0172 35.3 µM 1.17327250559335 0.118498482727266 no 479 0.120343272131592 589 5861980 SGTC_91 0417-1751 58.384 µM 1.170058411547 0.119117542062919 no 480 0.120988731628322 754 6795624 SGTC_401 neomycin 50 µM 1.16873759120043 0.119372603027174 no 481 0.121254685784285 614 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1949 st076024 69.1 µM 1.1686459116718 0.119390321369378 no 482 0.121273161189015 618 2921930 SGTC_54 0159-0055 9 µM 1.16577455601809 0.119946190172489 no 483 0.121852803539777 636 3319099 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.16292242456875 0.120500140953663 no 484 0.122430489127411 633 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1710 st031758 61.5 µM 1.1625086220651 0.120580660513512 no 485 0.122514462234249 623 5394341 SGTC_811 0416-0114 265 µM 1.16104915189265 0.120864953222864 no 486 0.12281095569399 623 6612453 SGTC_195 4234-0266 16.654 µM 1.16075923036023 0.120921483651158 no 487 0.12286991352773 702 2303354 SGTC_1156 4092-0367 4.88 µM 1.1580860881478 0.121443583723264 no 488 0.123414453328623 666 1357585 SGTC_1230 0170-0365 3.77 µM 1.15570764726447 0.121909455331804 no 489 0.123900379560574 802 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1339 1486-1321 22.7 µM 1.15403359344056 0.122238108575498 no 490 0.124243198294271 663 3469382 SGTC_1224 0823-0416 294 µM 1.1532460967967 0.122392926252388 no 491 0.124404693933101 669 3598164 SGTC_3269 9137823 49.47 µM 1.15208173662025 0.122622085377619 no 492 0.1246437436243 583 17682936 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.14855436369537 0.123318148430147 no 493 0.125369892084866 613 2346 DNA damaging agent; causes G2/M arrest. SGTC_1978 st071761 42 µM 1.1483175733091 0.123364973676407 no 494 0.125418743540904 627 5147680 SGTC_1297 1068-0111 14.1 µM 1.14550900639142 0.123921317371699 no 495 0.125999183381369 642 767057 SGTC_469 w7 172 µM 1.1444064981149 0.124140190377305 no 496 0.126227547295166 618 45115570 A P450 inhibitor. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.14166307801358 0.124685995116361 no 497 0.126797046811002 647 1609 A potent and irreversible inhibitor of serine proteases. SGTC_871 0574-0004 149 µM 1.14094757387764 0.124828620348929 no 498 0.126945870145685 719 9551173 SGTC_3079 9117512 49.47 µM 1.13618348095847 0.125781178782336 no 499 0.127939891263431 722 7185044 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.13509086129346 0.126000355947682 no 500 0.128168625100295 652 2724278 An inhibitor of dopamine biosynthesis. SGTC_1135 dihydrocapsaicin 536.708 nM 1.13067067240339 0.126889753514515 no 501 0.129096864794908 658 107982 A Capsaicinoid. SGTC_2330 7979373 200 µM 1.13045266653092 0.126933731842329 no 502 0.129142766332878 674 1863007 SGTC_1158 4092-0494 91.8 µM 1.12842945356339 0.127342380785107 no 503 0.129569297339517 703 1148199 SGTC_2883 9059145 45.46 µM 1.12689711317469 0.127652491555956 no 504 0.129892992032034 637 16476510 SGTC_611 3453-1652 23.7 µM 1.12339438516578 0.128363334347924 no 505 0.130635016708503 720 1560575 SGTC_1397 3532-0190 20.1 µM 1.11904304047702 0.129250216518842 no 506 0.131560888868381 602 5322280 SGTC_2971 9092186 9.93 µM 1.11769868720944 0.129525076645546 no 507 0.131847851821892 623 25236400 SGTC_1960 st011366 51.8 µM 1.11642846972117 0.129785151142018 no 508 0.132119386369835 674 3972846 SGTC_2734 clemastine 41.6 µM 1.11391036610859 0.130301796272347 no 509 0.132658820929026 565 26987 Clemastine is a selective histamine H1 antagonist. SGTC_56 0957-0365 83.25 µM 1.11368684526867 0.130347725216809 no 510 0.132706777338075 710 6752360 SGTC_2558 carylophyllene oxide 100 µM 1.11130431080928 0.130837983058197 no 511 0.13321869224632 731 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2085 5307070 144.047 µM 1.1077250934495 0.131576876960758 no 512 0.133990279370637 644 2840351 SGTC_2213 7173844 200 µM 1.10565203880685 0.132006153218513 no 513 0.134438578266018 723 892728 SGTC_1116 jasmonic acid  1.58368 µM 1.10547043698639 0.132043804241014 no 514 0.134477898731458 713 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2737 bleomycin 30.5 nM 1.10419773975668 0.132307876982888 no 515 0.134753684959785 755 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1683 st010134 710 nM 1.10385167302164 0.132379745490692 no 516 0.134828742710294 693 3818134 SGTC_879 0831-1030 162 µM 1.10155200901823 0.132858005619379 no 517 0.135328240985508 739 1549252 SGTC_224 benfluorex 43.875 µM 1.09726676695198 0.133752376563239 no 518 0.136262396984038 632 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.09658895220226 0.133894221197467 no 519 0.136410559555426 725 2333 A French combination drug. SGTC_2762 leflunomide 42.06 µM 1.09346862163336 0.134548538337867 no 520 0.137094049368665 736 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2418 pentamidine 31.67 µM 1.09204173429116 0.134848479354846 no 521 0.137407378824287 664 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2780 5215298 71.43 µM 1.09133360821436 0.13499750225862 no 522 0.137563057270452 753 2834131 SGTC_1579 chlormadinone acetate 49.4 µM 1.08889888548879 0.135510743615597 no 523 0.138099238895365 733 45114258 A steroidal progestin. SGTC_2617 dihydrotanshinone i 20.83 µM 1.08773207547311 0.135757181346823 no 524 0.138356701634329 745 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3182 9108849 49.47 µM 1.0855331959211 0.136222432619291 no 525 0.138842784675446 740 17133045 SGTC_3101 9120531 49.47 µM 1.08490781558676 0.136354953153739 no 526 0.138981243044532 728 24824904 SGTC_1151 3909-8316 15.3 µM 1.0837468386221 0.13660120249171 no 527 0.139238530957322 726 800431 SGTC_978 1416-0512 87.4 µM 1.08278748751167 0.136804915262073 no 528 0.139451380326683 753 6814003 SGTC_826 1683-5028 118 µM 1.08262818260697 0.136838762850337 no 529 0.139486746412899 721 722377 SGTC_585 0kpi-0023 191 µM 1.08200339465006 0.136971567088394 no 530 0.139625509776143 670 64601 SGTC_1325 1431-0015 227 µM 1.08159697829842 0.137058001765047 no 531 0.139715823892636 679 1103340 SGTC_3056 9094900 49.47 µM 1.08052921611283 0.137285265840763 no 532 0.139953291942323 701 25236784 SGTC_3051 9093778 49.47 µM 1.07956179934451 0.137491394356723 no 533 0.140168680085484 658 17217378 SGTC_187 1488-2104 32.728 µM 1.07538580738356 0.138383601255009 no 534 0.141101016668233 751 2852859 SGTC_3174 9107204 49.47 µM 1.074188502935 0.13864013339944 no 535 0.141369102119532 700 3938802 SGTC_849 0386-0493 241 µM 1.07083496782523 0.139360379026156 no 536 0.142121820492401 707 726119 SGTC_1968 st069590 43.6 µM 1.06555660873355 0.14049917158659 no 537 0.143312061460474 713 6384066 SGTC_1041 0206-0046 107 µM 1.06163163566581 0.141350058999363 no 538 0.144201473034346 738 50494 SGTC_1686 st019653 115.5 µM 1.06072937287033 0.141546151540459 no 539 0.144406453618851 750 97252 SGTC_1662 st014054 52 µM 1.06064024230996 0.141565532655849 no 540 0.144426713398073 711 2838777 SGTC_2297 7971671 152.32 µM 1.06013723603048 0.141674943241886 no 541 0.144541084905059 724 909016 SGTC_342 k048-0088 23.3 µM 1.06006868797159 0.141689857794121 no 542 0.144556675805057 728 6820570 SGTC_1410 3909-8106 77.9 µM 1.05921446100976 0.141875808029153 no 543 0.14475106032503 735 1039210 SGTC_2885 9057732 51.95 µM 1.05896182687728 0.141930833698788 no 544 0.144808582466585 717 6471414 SGTC_2382 9035899 200 µM 1.05756338660916 0.142235686160107 no 545 0.145127271051933 758 6462679 SGTC_64 000l-0018 272.079 µM 1.05681966988119 0.142397992756544 no 546 0.145296947728938 828 6811119 SGTC_2104 5389443 200 µM 1.05492402916884 0.142812258401956 no 547 0.145730035741595 778 2244536 SGTC_865 0488-0499 301 µM 1.05344412617558 0.143136236103582 no 548 0.146068744717885 801 9634651 SGTC_1518 st038567 90.8 µM 1.05001017133566 0.143889902692928 no 549 0.146856718179967 732 77966 SGTC_489 paxilline 115 µM 1.04561443951116 0.14485855511438 no 550 0.147869539945031 712 105008 A toxic potassium channel blocker. SGTC_2715 st079500 56.4 µM 1.04295745586209 0.145446177716521 no 551 0.148483998643408 706 28246688 SGTC_1198 1612-1005 86.7 µM 1.03899087673235 0.146326411991409 no 552 0.149404489655276 784 6998509 SGTC_1368 1852-0141 284 µM 1.03736358257903 0.146688561844589 no 553 0.149783221863632 736 2838987 SGTC_2889 9059656 51.95 µM 1.0368529467932 0.146802326305302 no 554 0.149902197802643 798 3949838 SGTC_418 lividomycin a 100 µM 1.03609802120566 0.146970624461448 no 555 0.150078207649043 822 72394 An antibiotic. SGTC_1562 morin hydrate 59.1 µM 1.03604711375832 0.146981978088812 no 556 0.150090081605994 745 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2370 9071495 200 µM 1.03019300215587 0.148291514161155 no 557 0.151459707028551 729 21791103 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.02892013796817 0.148577277489974 no 558 0.151758602228895 696 61125 An anti-inflammatory. SGTC_2937 9044753 11.33 µM 1.02549853848356 0.149347264885372 no 559 0.152564007334585 812 6465530 YGL099W LSG1 SGTC_282 k297-0036 65.7 µM 1.02452592158837 0.149566625333314 no 560 0.152793466870969 766 5061378 SGTC_969 1313-0238 134 µM 1.02338984805358 0.149823123309588 no 561 0.153061778720846 810 5212874 SGTC_2455 5377712 9.75 µM 1.02199630098465 0.150138153045471 no 562 0.153391325571852 694 2243908 SGTC_1467 k284-1082 293 µM 1.02081943358977 0.150404543146404 no 563 0.153669997691091 821 3334705 SGTC_1681 tripelennamine 100 µM 1.01495057205508 0.151737689319465 no 564 0.15506469477528 718 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1032 k061-1018 98.7 µM 1.01100768611585 0.152637735775956 no 565 0.156006375545277 877 4005393 SGTC_1386 3228-0095 33.8 µM 1.00943260489799 0.152998269113738 no 566 0.156383604086739 755 870181 SGTC_2212 7123476 200 µM 1.00769481956257 0.153396699661023 no 567 0.15680049636959 708 1085715 SGTC_5 0352-0601 109.883 µM 1.00569696162084 0.153855606896541 no 568 0.157280682604193 761 762456 SGTC_2227 7312221 64.1025 µM 1.00393840543539 0.154260297743292 no 569 0.157704151718433 825 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1237 0330-0133 46.1 µM 1.00229836624652 0.154638348485699 no 570 0.158099755688666 773 X1237 YHR072W ERG7 SGTC_1411 3909-8223 150 µM 0.999616979208826 0.155257761445059 no 571 0.158747951498952 852 X1411 SGTC_134 0269-0018 6.916 µM 0.999442426731141 0.155298140579303 no 572 0.158790207952185 780 4378915 SGTC_1197 1601-0112 267 µM 0.997937713988147 0.155646512379416 no 573 0.159154781325146 823 7350313 SGTC_851 0394-0702 453 µM 0.997871481502715 0.155661858389288 no 574 0.159170841229176 861 762646 SGTC_778 3456-2434 196 µM 0.996563052702252 0.155965224788661 no 575 0.159488323708916 903 5539063 SGTC_2917 7979103 53.79 µM 0.996450162807938 0.155991417179885 no 576 0.159515735183721 854 2980565 SGTC_787 4152-0075 138 µM 0.995300499428166 0.156258323892727 no 577 0.159795067478559 780 9566539 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.99513182465602 0.156297508847093 no 578 0.159836077083161 842 5393153 SGTC_573 3702-0553 84.7 µM 0.992475831354242 0.156915377852271 no 579 0.160482731763434 792 1222756 SGTC_1783 st039459 87.517 µM 0.991478601060078 0.15714777990957 no 580 0.160725968160482 858 729761 SGTC_463 ikarugamyin 104 µM 0.989196556662613 0.157680455958716 no 581 0.16128349140034 788 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1103 duloxetine 36.1 µM 0.98543740593826 0.158560502247626 no 582 0.16220463172041 896 60835 A selective serotonin reuptake inhibitor. SGTC_623 k072-0108 16.9 µM 0.985333183014933 0.158584947443764 no 583 0.162230219157085 795 5382803 SGTC_2094 5332512 191.667 µM 0.984998799976452 0.158663392736655 no 584 0.162312330207871 862 755774 SGTC_1289 0976-0073 69.1 µM 0.984775840249772 0.15871571257869 no 585 0.162367095197116 854 3391136 SGTC_842 0271-0008 11.1 µM 0.983447999191758 0.159027538674441 no 586 0.162693498246935 862 1221709 SGTC_1076 itraconazole 331 nM 0.983254984846892 0.159072898959347 no 587 0.162740979544602 844 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_272 doxorubicin 8.13 µM 0.981827815921035 0.159408560835994 no 588 0.16309234105968 853 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_422 cantharidin 155 µM 0.979647981041088 0.159922139786246 no 589 0.163629955933689 810 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1501 4491-0275 38.4 µM 0.979627920082389 0.159926871258848 no 590 0.163634908925413 843 5104718 SGTC_1474 0330-0125 5.35 µM 0.978684123450851 0.160149573663545 no 591 0.163868039550234 835 X1474 SGTC_2239 6685329 187.64 µM 0.976215126513001 0.160733127504139 no 592 0.164478934382182 812 805680 SGTC_1459 k035-0031 35.7 µM 0.973944654543443 0.161270983443517 no 593 0.165042010075074 740 3877128 YMR208W ERG12 SGTC_3300 9124615 50.48 µM 0.972213721452785 0.161681814891902 no 594 0.165472117846264 826 24824903 SGTC_2614 arthonioic acid 13.39 µM 0.969894750430551 0.162233283423124 no 595 0.166049478505639 785 6710684 SGTC_552 k242-0005 476 µM 0.966338800073273 0.163081290692981 no 596 0.166937338462874 819 4088318 SGTC_1303 1160-0052 261 µM 0.965546722866395 0.16327057339833 no 597 0.167135522806569 850 3562476 SGTC_2049 5262831 67.185 µM 0.96489752620979 0.163425818333365 no 598 0.16729807030813 830 763417 SGTC_2842 9000675 19.48 µM 0.963251166536533 0.163819948498433 no 599 0.16771074666947 775 2989072 SGTC_786 4544-0069 423 µM 0.956824296252951 0.165364407772253 no 600 0.169327973407663 867 748821 YLR208W SEC13 SGTC_1985 st071382 65.5 µM 0.953912424891295 0.166067258931739 no 601 0.170063986801607 857 6123237 SGTC_2359 9039622 200 µM 0.953504325192844 0.166165917733256 no 602 0.170167302892995 889 6463596 SGTC_2903 5923464 63.88 µM 0.95247737079909 0.166414353199887 no 603 0.170427468528099 835 2876576 SGTC_603 3794-0023 45.9 µM 0.952472020294819 0.166415648193737 no 604 0.170428824676002 842 3802260 SGTC_825 1988-2224 89.6 µM 0.949819158135376 0.167058527346633 no 605 0.171102074768582 850 1180859 SGTC_2162 5663267 200 µM 0.949306526062455 0.167182939997638 no 606 0.17123236767617 889 6456493 SGTC_2084 5306078 60.6385 µM 0.948373854406929 0.167409446822961 no 607 0.171469582420584 832 679340 SGTC_2056 5235370 200 µM 0.948001849309203 0.167499846397803 no 608 0.171564256374332 809 5511916 SGTC_2029 5175081 200 µM 0.947763975890427 0.167557667613511 no 609 0.171624811803904 898 1380876 SGTC_2168 5727979 200 µM 0.947634838602268 0.167589063117017 no 610 0.171657691997931 781 695210 SGTC_2157 5649910 96.377 µM 0.946480721366624 0.167869817179024 no 611 0.171951725370885 842 2858091 SGTC_770 0389-1121 67.2 µM 0.94647991299913 0.167870013931008 no 612 0.171951931430547 903 6753108 SGTC_2841 9004761 38.96 µM 0.946404153125978 0.16788845410592 no 613 0.17197124395808 779 2991039 SGTC_2080 5212524 12.4 µM 0.946124551995551 0.167956521125949 no 614 0.172042531202221 849 260183 SGTC_274 sirtinol 40.1 µM 0.946093562681375 0.167964066359955 no 615 0.172050433414327 851 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2436 5633522 8.09 µM 0.945471239812478 0.168115634825661 no 616 0.172209173523233 891 5724242 SGTC_3193 9111931 49.47 µM 0.945434844758653 0.16812450166536 no 617 0.172218459947902 859 17087244 SGTC_3075 9116269 49.47 µM 0.944573513965483 0.168334433446655 no 618 0.172438327128857 850 17015205 YNL244C SUI1 SGTC_1597 7-benzyloxygramine 47.5 µM 0.943354342376507 0.168631869691816 no 619 0.172749844278847 949 260807 SGTC_1642 st009582 77.7 µM 0.941048693995541 0.169195292097585 no 620 0.173339953004465 837 6739311 SGTC_867 0518-0118 155 µM 0.93755813405018 0.170050563908491 no 621 0.174235767540363 869 6848158 SGTC_608 k048-0125 159 µM 0.936944829143808 0.170201124196272 no 622 0.174393468961814 885 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_41 0478-0632 82.643 µM 0.93674555760397 0.170250061767039 no 623 0.174444727921446 949 3750424 SGTC_226 1,3-diallylurea 8.28947 mM 0.935932658037785 0.170449788928959 no 624 0.17465393060673 825 74537 YKL182W FAS1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.93545654208416 0.170566838947056 no 625 0.174776534735286 860 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2456 5770359 74.46 µM 0.932718995489788 0.171240845345006 no 626 0.175482537279963 908 3118787 SGTC_2986 9022445 71.43 µM 0.932232875908773 0.171360709776732 no 627 0.17560809435361 880 6459286 SGTC_1613 st002381 52.1 µM 0.928365906285618 0.172316113317096 no 628 0.176608898738574 934 551167 SGTC_2732 terfenadine 20 µM 0.928090382709423 0.172384315761834 no 629 0.176680343952929 857 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_80 0159-0065 512.242 µM 0.926896565755717 0.172680029256743 no 630 0.176990120234073 809 1548079 SGTC_2352 9027995 87.8 µM 0.924918282697417 0.173170769821605 no 631 0.177504207880695 831 2997347 SGTC_439 amiodarone 34.4 µM 0.922421378107275 0.173791428321428 no 632 0.17815441147159 878 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1932 st074806 40.9 µM 0.921642797123739 0.173985250136041 no 633 0.178357463630945 940 17251235 SGTC_1868 st057644 42.7 µM 0.921128174867826 0.174113436846175 no 634 0.178491755962978 954 688665 SGTC_1705 st027868 56.3335 µM 0.920979086742544 0.174150584260804 no 635 0.178530672884134 910 292948 SGTC_1940 st075990 51.1 µM 0.920193627772162 0.174346375640009 no 636 0.178735791836206 932 1084979 SGTC_333 3486-0131 40.1 µM 0.919301602746586 0.17456890027135 no 637 0.178968919871785 939 6744690 SGTC_2262 9014885 67.46 µM 0.919128251253637 0.174612165470143 no 638 0.17901424695467 845 6457424 SGTC_8 0354-0001 70 µM 0.918472155551449 0.174775975984544 no 639 0.179185864979768 960 4993152 SGTC_1174 0739-0097 51.1 µM 0.915878606392657 0.175424474229016 no 640 0.179865284393941 880 728447 SGTC_446 go6976 132 µM 0.915676006804096 0.175475196945596 no 641 0.179918426469075 868 3501 A protein kinase C inhibitor. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.914573909316068 0.175751280243585 no 642 0.180207680431393 971 551469 SGTC_2406 ethylparaben 405.7 µM 0.913713719519133 0.175966955031145 no 643 0.180433646548566 741 8434 A possible steroid mimic. SGTC_991 3996-0057 64.7 µM 0.911075880379806 0.176629383010494 no 644 0.181127696987111 859 715343 SGTC_682 0kpi-0099 17 µM 0.908583901559289 0.177256628298029 no 645 0.181784903691705 916 1714895 YML126C ERG13 SGTC_2464 5717415 7.67 µM 0.907117353122339 0.177626423607234 no 646 0.182172371196652 902 5285744 SGTC_3150 9097574 49.47 µM 0.907091705289287 0.177632895126293 no 647 0.18217915203836 896 17217476 SGTC_1181 1222-0449 220 µM 0.907014710008484 0.177652323642867 no 648 0.182199509201311 908 658318 SGTC_860 0443-0016 25.1 µM 0.906628112329165 0.177749895595951 no 649 0.182301745163232 965 5337942 SGTC_1475 4092-1048 11.7 µM 0.904979998404704 0.178166236133431 no 650 0.182737991811362 917 2881759 SGTC_2744 captopril 92.04 µM 0.90472135551751 0.178231629315072 no 651 0.182806512271502 860 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1578 josamycin 24.2 µM 0.90374874141013 0.178477672594399 no 652 0.18306432368207 826 5282165 A P450 substrate. SGTC_1825 st052143 62.6 µM 0.903415686951147 0.178561974907067 no 653 0.183152658741174 880 674173 SGTC_1766 st045414 44.774 µM 0.903213490483679 0.178613166846772 no 654 0.183206299686369 963 253960 SGTC_2216 7189485 200 µM 0.903090875747544 0.17864421484868 no 655 0.183238833069873 940 731273 SGTC_2655 perillic acid 100 µM 0.903069429506055 0.178649645727396 no 656 0.18324452377403 875 5702197 An apoptosis inducer. SGTC_1437 4092-1038 11.6 µM 0.901210864821171 0.179120688990161 no 657 0.183738107652759 952 3977136 SGTC_321 4534-3890 65.3 µM 0.897224912660035 0.180133538942215 no 658 0.184799457092004 934 699746 SGTC_2543 pimpinellin 60.67 µM 0.896728318543618 0.180259977318812 no 659 0.184931952894492 866 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_717 1532-0246 73.2 µM 0.894988356072981 0.180703430395742 no 660 0.185396656216604 888 9561992 SGTC_3162 9099653 49.47 µM 0.894593961088785 0.180804042329203 no 661 0.185502090595863 888 25237511 SGTC_3126 9127922 49.47 µM 0.893196399133366 0.18116084927984 no 662 0.185876003050317 890 45595682 SGTC_609 0986-0026 86.3 µM 0.893031146767624 0.181203068458897 no 663 0.185920246580739 919 2848610 SGTC_2290 7904846 200 µM 0.892912440047335 0.181233399817341 no 664 0.18595203233056 910 2962154 SGTC_2774 tamoxifen 10.92 µM 0.892822851793283 0.181256293073557 no 665 0.185976023345155 919 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3286 9117135 37.221 µM 0.892556210521132 0.181324440924586 no 666 0.18604743909076 872 3438150 SGTC_1826 st055655 41.6 µM 0.892032482267783 0.181458341449667 no 667 0.186187761095226 920 676168 SGTC_1665 st014639 11.4 µM 0.891314052219145 0.181642121646303 no 668 0.186380356029633 973 981133 YIL048W NEO1 SGTC_1129 3453-1384 223 µM 0.890990496014017 0.181724927957503 no 669 0.186467134462164 945 1084452 SGTC_405 ebelactone b 50 µM 0.883603311363168 0.183621918712315 no 670 0.188455195439504 918 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2926 9010726 65.15 µM 0.880273661864405 0.184480975164538 no 671 0.189355538562897 911 2994293 SGTC_3206 9114350 49.47 µM 0.879429149533845 0.184699257887801 no 672 0.189584316436646 858 17087243 SGTC_1444 4112-3581 28 µM 0.879221200252685 0.184753031565447 no 673 0.189640675850908 965 2877249 SGTC_1009 4106-0057 9.87 µM 0.878009644957386 0.185066521570845 no 674 0.189969242301921 991 2928005 SGTC_607 4491-0986 66.8 µM 0.877765324647553 0.185129779480885 no 675 0.190035542862865 977 698981 YDR232W HEM1 SGTC_3167 9103034 49.47 µM 0.876507994900097 0.185455531917458 no 676 0.190376966005242 912 5127859 SGTC_2148 5546263 113.568 µM 0.875872310959384 0.185620361982313 no 677 0.190549726871463 940 792097 SGTC_1947 st076332 61.6 µM 0.873983789859571 0.186110583184598 no 678 0.191063540803572 934 24208416 SGTC_44 0929-0055 61.211 µM 0.872935873177495 0.186382946648457 no 679 0.191349015894241 875 1379590 SGTC_1704 st028805 70.8 µM 0.869600613502888 0.187251454587777 no 680 0.192259351198612 931 2876101 SGTC_2534 helenine 20.12 µM 0.866211180056378 0.188136628645203 no 681 0.193187181719114 913 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3310 9130229 44.1445 µM 0.865871476870386 0.188225486645901 no 682 0.193280323227128 933 7761258 SGTC_501 nsc-95397 161 µM 0.863175378073439 0.188931637810882 no 683 0.194020524492224 919 262093 SGTC_2859 9028643 45.46 µM 0.861792855703168 0.189294374635633 no 684 0.194400758523432 928 17151580 SGTC_2194 5927483 104.545 µM 0.859621911272758 0.189864836779153 no 685 0.194998746345401 1012 760979 SGTC_1845 st056753 3.01 µM 0.857835376473872 0.190335079011442 no 686 0.195491686189271 974 5375839 SGTC_2066 5222451 176 µM 0.85772025227849 0.190365405906982 no 687 0.195523477136875 1030 2281147 SGTC_1428 4049-0204 61.7 µM 0.856684662508089 0.190638342283346 no 688 0.195809590983961 1010 X1428 SGTC_2450 5739737 12.93 µM 0.855888681977142 0.190848291275244 no 689 0.196029677946862 917 2262825 SGTC_1499 4480-0877 67.3 µM 0.853506763558742 0.191477396497928 no 690 0.19668916926289 916 2861909 SGTC_1105 epirubicin 18.1 µM 0.852274880504533 0.191803255697645 no 691 0.197030772278052 934 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3249 9135183 49.47 µM 0.850795125959056 0.192195130741632 no 692 0.197441584823316 1004 4902779 SGTC_627 1391-0720 175 µM 0.850764296916078 0.192203300227985 no 693 0.197450149150782 938 997839 SGTC_2429 5902844 64.44 µM 0.850760279475354 0.192204364838051 no 694 0.197451265214878 1009 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_681 1642-0006 26.6 µM 0.850681887679695 0.192225139157013 no 695 0.197473043591084 983 4446530 SGTC_2276 7947513 42.08 µM 0.850669256825095 0.192228486541412 no 696 0.197476552761288 928 2105100 SGTC_2313 7726885 200 µM 0.850295854841102 0.192327460321447 no 697 0.197580310289828 922 726423 SGTC_3137 9097352 49.47 µM 0.849955474411152 0.192417708568794 no 698 0.19767492079766 1011 44120435 SGTC_2907 7721985 69.9 µM 0.849640187052344 0.192501326751849 no 699 0.197762580978876 987 3267881 SGTC_3335 9143315 29.6265 µM 0.847517612922542 0.193064838157914 no 700 0.198353337043965 946 4899691 SGTC_2890 9046729 58.44 µM 0.847470122142397 0.193077457752193 no 701 0.198366566873972 895 903329 SGTC_200 k038-0079 37.545 µM 0.846670420327042 0.193290035951284 no 702 0.198589425223215 956 3436683 SGTC_966 1300-0360 30.2 µM 0.846284680803919 0.193392624981254 no 703 0.198696975849011 936 70588 SGTC_2171 5739187 198.077 µM 0.845174065085998 0.193688183321625 no 704 0.199006830155327 957 2262761 SGTC_370 0180-0345 38.7 µM 0.844555255694398 0.193852981006642 no 705 0.199179600048305 908 3989527 SGTC_1504 k297-0033 30 µM 0.844247581710192 0.193934950737092 no 706 0.19926553540242 864 4388117 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.843379557181886 0.194166321484824 no 707 0.199508100655838 1073 6708784 An antioxidant flavonoid SGTC_631 k072-0230 41.5 µM 0.842943001591593 0.19428274829435 no 708 0.199630161142572 1001 5773147 SGTC_145 3737-0113 38.366 µM 0.841455216837538 0.194679850951026 no 709 0.200046481611047 1091 6849351 SGTC_3352 9151559 45.5865 µM 0.841092360254729 0.194776775374491 no 710 0.200148097340342 947 17159339 SGTC_2451 5856223 45.7 µM 0.840585342856613 0.194912256460618 no 711 0.200290136358459 954 2179896 SGTC_329 k048-0121 21.3 µM 0.84045801201504 0.194946289778397 no 712 0.200325817127896 961 6832902 SGTC_673 1082-0474 110 µM 0.840140305654538 0.195031222913155 no 713 0.20041486175649 1084 3098046 SGTC_722 3534-0461 190 µM 0.839047348841227 0.195323577208811 no 714 0.200721369963041 1015 658262 SGTC_624 k048-0052 28 µM 0.836902158970194 0.195898166233449 no 715 0.201323783357268 949 6835531 SGTC_2109 5483026 200 µM 0.835096089771977 0.196382716140322 no 716 0.201831804063413 996 759335 SGTC_36 0335-0881 14.2 µM 0.834090840907832 0.196652728551395 no 717 0.202114897991424 1002 23828853 SGTC_2565 isoliquiritigenin 100 µM 0.82954256158829 0.197877216051721 no 718 0.203398731690358 845 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2611 pyromycin 23.93 µM 0.828357618379583 0.198196981107762 no 719 0.203734000440667 972 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1331 1472-0049 76.2 µM 0.828232378118518 0.198230796269267 no 720 0.203769455258384 980 24051409 SGTC_2642 cholecalciferol 100 µM 0.827517463341957 0.198423891590999 no 721 0.203971914048427 999 9821465 A vitamin D precursor, similar to steriods. SGTC_1091 telmisartan 47.6 µM 0.825419037097618 0.198991322335729 no 722 0.204566865292611 1056 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3214 9129694 49.47 µM 0.824273356680293 0.199301535459769 no 723 0.204892126903623 972 17158655 SGTC_2873 9040596 71.43 µM 0.822500988680249 0.199782008600939 no 724 0.205395912105839 1027 6463863 SGTC_149 3970-0822 46.1 µM 0.819851334831949 0.200501604181737 no 725 0.206150431146768 1102 3114250 YBL034C STU1 SGTC_1722 st034304 3.6505 µM 0.819563625379149 0.200579834173936 no 726 0.206232458471127 1012 4036148 YLR033W RSC58 SGTC_3084 9116877 49.47 µM 0.81944165609423 0.200613003913205 no 727 0.206267238329178 945 27241325 SGTC_940 3232-1287 54.8 µM 0.819129675697534 0.200697862458304 no 728 0.206356216166425 1022 1585493 YIL048W NEO1 SGTC_1488 4013-0813 75.9 µM 0.818721797283524 0.200808837721037 no 729 0.206472578735107 961 2910057 SGTC_2062 5245942 200 µM 0.818468202750972 0.200877854099884 no 730 0.206544945651704 1108 1376160 SGTC_1363 1636-0063 10.4 µM 0.818063516376415 0.200988019972596 no 731 0.206660459952578 1049 6072185 SGTC_1809 st050081 57.6 µM 0.817779342873167 0.20106540084898 no 732 0.206741597733748 1015 5036894 SGTC_148 3253-0744 288.01 µM 0.815729927264831 0.201623988767078 no 733 0.207327309208235 1045 6893655 SGTC_892 0929-0076 29 µM 0.815379667283287 0.20171954842116 no 734 0.207427509623656 1038 5751038 SGTC_655 k060-0012 42 µM 0.815168248613781 0.201777241829773 no 735 0.207488004945436 989 5994525 SGTC_795 0685-0265 78 µM 0.813142610788742 0.202330512792909 no 736 0.20806814919721 1098 302754 SGTC_761 k216-0224 480 µM 0.812521878525673 0.202500237452766 no 737 0.208246118874409 1076 1340404 SGTC_889 0919-1524 82.7 µM 0.809518405994146 0.203322668051175 no 738 0.209108510001381 980 3905452 SGTC_3091 9116372 49.47 µM 0.80768567310686 0.20382549677902 no 739 0.209635776600889 986 17169793 SGTC_1854 st056233 32.9 µM 0.807434448114885 0.20389448060393 no 740 0.209708113456599 992 5393174 SGTC_839 0122-0028 230 µM 0.806639695596819 0.204112803167035 no 741 0.209937048385088 1044 759448 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.806413423550906 0.204174986706923 no 742 0.210002254740428 1013 5357218 A potent inhibitor of glutathione S-transferases. SGTC_237 nikkomycin 200 µM 0.805605980298475 0.20439697827122 no 743 0.210235038142059 1040 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_265 mycophenolic acid 32.932 µM 0.805582667248298 0.204403389895806 no 744 0.210241761472659 1082 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1316 1272-0050 65.9 µM 0.80505561306853 0.204548373854159 no 745 0.21039379413098 1029 7340392 SGTC_520 3584-0023 682 µM 0.804596957376662 0.204674592294649 no 746 0.21052614924803 944 1340790 SGTC_1839 st053978 48 µM 0.804005760453978 0.204837353372651 no 747 0.210696824098654 1051 3788398 SGTC_883 0850-0245 24.6 µM 0.804002158990557 0.20483834511915 no 748 0.210697864067286 1049 6823229 YPR165W RHO1 SGTC_1044 1222-0021 1.78 µM 0.802762957469315 0.20517975749932 no 749 0.211055878103659 988 4306703 SGTC_1033 k072-0102 21.3 µM 0.802560803354008 0.205235485036245 no 750 0.211114315660084 1038 5965931 SGTC_2755 lomerizine 42.69 µM 0.802216558242533 0.205330403288084 no 751 0.211213849890024 1067 3949 A calcium channel blocker. SGTC_2583 asiatic acid 100 µM 0.801155887196697 0.205623024619756 no 752 0.211520702673252 1035 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.80051868383087 0.205798937293223 no 753 0.211705171436089 1087 3256 An antibiotic and ribosome inhibitor. SGTC_2411 st077133 39.94 µM 0.800293287770551 0.205861183736248 no 754 0.211770445561621 1068 1403142 YNL221C POP1 SGTC_2855 9016525 58.44 µM 0.799927636478303 0.205962187482631 no 755 0.211876362291139 1082 43811474 SGTC_554 4483-2211 187 µM 0.799867616702361 0.205978769535223 no 756 0.211893750937186 986 747107 SGTC_731 3966-0296 387 µM 0.799535109070887 0.206070647917471 no 757 0.211990098600438 1055 660956 SGTC_3243 9134147 49.47 µM 0.798757667274505 0.20628556515549 no 758 0.212215470689198 1106 24282180 SGTC_599 1935-0052 86.5 µM 0.797805857558622 0.206548865739526 no 759 0.212491580790391 1074 9557311 SGTC_89 0302-0250 142.109 µM 0.797541740649411 0.206621964074515 no 760 0.212568235539663 1149 4203518 YLR208W SEC13 SGTC_2093 5331342 194.4 µM 0.797271177539698 0.206696862376761 no 761 0.212646777916691 1053 33839 SGTC_1390 3413-2614 145 µM 0.796326756561594 0.206958426525894 no 762 0.212921068803625 1102 3421432 SGTC_16 erodoxin 22.806 µM 0.7932830215536 0.207802742560374 no 763 0.213806473283595 1093 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1400 3771-8998 51.5 µM 0.791074466604838 0.208416655715526 no 764 0.214450269035981 1004 670767 SGTC_1862 st057513 3.81 µM 0.790708842501376 0.208518391536235 no 765 0.214556957434875 1072 5393163 SGTC_2282 7944268 200 µM 0.789174711386968 0.208945586438032 no 766 0.215004950106791 1047 2970414 SGTC_1661 st013063 9.66 µM 0.787223203820812 0.209489748527466 no 767 0.215575608101667 1122 721395 SGTC_1609 st001574 46.4 µM 0.784719733032731 0.210189040491883 no 768 0.216308955225445 1085 3960012 SGTC_3154 9100113 49.47 µM 0.780810930517431 0.211283619533129 no 769 0.217456852145476 1084 25237525 SGTC_756 0508-1999 28.3 µM 0.780735422265363 0.211304796876805 no 770 0.217479061199383 1037 6753853 SGTC_1666 st014829 29 µM 0.7786847792271 0.211880403640169 no 771 0.218082712176011 1097 3858230 SGTC_1253 0550-0034 176 µM 0.778021099603748 0.21206689198136 no 772 0.218278287256378 1016 5969915 SGTC_2261 9010538 184.68 µM 0.777893927286045 0.212102637278098 no 773 0.218315774305601 1003 6457250 SGTC_1356 1502-0781 85.8 µM 0.777557038440887 0.212197346230256 no 774 0.218415098187158 1014 567702 SGTC_3252 9135871 49.47 µM 0.777152166001712 0.212311199989287 no 775 0.218534499885853 1113 17682838 SGTC_1471 k673-0312 37 µM 0.776691311335575 0.212440839889345 no 776 0.218670457136757 1110 24099884 SGTC_2271 7849410 118.62 µM 0.773488300200093 0.213343134111429 no 777 0.219616725128984 1083 972430 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.773046367493314 0.213467802541387 no 778 0.219747470003575 1114 16623 A steroid. SGTC_2526 patulin 37.61 µM 0.772472893660895 0.213629641769187 no 779 0.219917197645437 1095 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_918 glabranin 770.725 nM 0.771759977553337 0.213830932436978 no 780 0.220128300043674 1070 124049 Also referred to as licorice root. SGTC_1614 st002383 48.6 µM 0.769551551796696 0.214455178296547 no 781 0.220782976689885 1130 1947235 SGTC_3272 9137413 49.47 µM 0.767551868009864 0.215021333048764 no 782 0.22137673352892 1080 17614870 SGTC_2025 5147754 141 µM 0.766843487415414 0.215222099270146 no 783 0.221587288514231 1079 315777 YLR208W SEC13 SGTC_2349 9023730 187.07 µM 0.765337342387543 0.215649325898525 no 784 0.222035346595462 1069 4126287 SGTC_2303 7774051 200 µM 0.765326960817289 0.215652272395443 no 785 0.222038436768098 1070 2953184 SGTC_2991 9074669 71.4286 µM 0.761687295490134 0.216686719877002 no 786 0.223123329810342 1099 17333109 SGTC_423 5-fluorouracil 457 µM 0.761005582067882 0.216880791670083 no 787 0.223326866570119 1059 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2114 5491910 81.25 µM 0.759537836690625 0.217298973796734 no 788 0.223765444553955 1094 2849228 SGTC_529 4076-0302 30.3 µM 0.757723648996751 0.217816505351829 no 789 0.224308219191437 1042 5816522 SGTC_2533 agelasine 13.65 µM 0.757372062425508 0.217916884287688 no 790 0.224413494410989 1132 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_298 1391-0729 10 µM 0.75569452224716 0.21839619376353 no 791 0.224916184535358 1083 3237558 SGTC_3011 9081274 71.4286 µM 0.75293100610536 0.219187112677824 no 792 0.225745687404803 1123 6625322 SGTC_3165 9101544 49.47 µM 0.752757555546428 0.219236809122778 no 793 0.225797808345799 1097 5002184 SGTC_691 1548-0686 185 µM 0.752129044712281 0.219416942085994 no 794 0.225986729407657 1108 46495133 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.750190230323459 0.219973147168493 no 795 0.226570070992433 1116 2724 A muscle relaxant with antifungal properties. SGTC_1733 st037357 54.9 µM 0.74935647503465 0.220212582560193 no 796 0.226821188592238 1127 1272339 YGL099W LSG1 SGTC_66 0109-0187 42.4 µM 0.747655711313575 0.220701465976786 no 797 0.227333925777718 1030 759417 SGTC_124 0136-0217 7.121 µM 0.747393012004998 0.220777034107295 no 798 0.22741318114961 1249 3976905 SGTC_3353 9151644 39.2805 µM 0.74636570460267 0.22107269177042 no 799 0.227723265247819 1108 4909158 SGTC_890 0929-0006 47.2 µM 0.745414029167419 0.221346784709249 no 800 0.22801073270189 1117 1378169 SGTC_1371 2421-0008 32.7 µM 0.743975655486257 0.221761420668298 no 801 0.228445601595017 1079 2827552 SGTC_3314 9135860 59.4275 µM 0.743897681249128 0.221783910755473 no 802 0.228469189145769 1135 25252478 SGTC_2796 7949634 45.45 µM 0.743302285888442 0.221955683423725 no 803 0.228649343975987 1090 2971588 SGTC_1629 st005085 44.9 µM 0.735955470363417 0.224081495863135 no 804 0.230878898870948 1136 24207091 SGTC_502 l-744,832 89.3 µM 0.735175553200573 0.224307843132558 no 805 0.231116292787529 1121 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2683 piperine 63.03 µM 0.733485148324143 0.224798877075399 no 806 0.231631291412648 1092 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_957 1187-1561 14.1 µM 0.733348599606182 0.224838568749711 no 807 0.231672920234902 1147 1538454 SGTC_3014 9081533 49.47 µM 0.733170872969719 0.224890235879564 no 808 0.231727108976397 1137 21367265 SGTC_3130 9127414 49.47 µM 0.731845138649226 0.225275854029873 no 809 0.232131547293282 1178 1494646 SGTC_3285 9112818 20.8695 µM 0.729699888038439 0.225900638537121 no 810 0.232786824789141 1200 17017947 YPR165W RHO1 SGTC_47 0149-0135 24.25 µM 0.729400232155637 0.225987988480329 no 811 0.232878437917023 1122 5239155 SGTC_222 nsc-310342 10.666 µM 0.728915677641017 0.226129276925631 no 812 0.233026622064922 1105 432556 SGTC_306 1672-3436 11.6 µM 0.727936282994939 0.226415005305794 no 813 0.233326295675111 1164 6797378 SGTC_2641 levomentholum 100 µM 0.727452958787895 0.226556085305365 no 814 0.23347426121324 1118 16666 SGTC_1254 0550-0035 264 µM 0.727217480485343 0.226624838258501 no 815 0.233546369716943 1170 15121435 SGTC_394 menadione 8.33 µM 0.726046993360419 0.226966761840151 no 816 0.233904981178716 1127 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3040 9091894 49.47 µM 0.725464606025032 0.227136997598617 no 817 0.23408352542892 1065 25236966 SGTC_2557 derrustone 83.84 µM 0.724311989366914 0.227474127343558 no 818 0.234437109014919 1163 629853 An antioxidant. SGTC_1034 k072-0165 12.7 µM 0.724287225852803 0.227481373534351 no 819 0.234444708860059 1161 5835461 SGTC_2448 5185112 27.17 µM 0.723565016370557 0.227692760478855 no 820 0.234666412643144 1132 5718189 SGTC_1194 1488-0194 225 µM 0.723365102557195 0.227751293742586 no 821 0.234727802643446 1137 1391452 SGTC_1912 st060209 90.8 µM 0.723156558615703 0.227812362867449 no 822 0.234791852265082 1134 688787 SGTC_1606 st000094 49.2 µM 0.722455251061898 0.228017798388774 no 823 0.235007314100408 1189 1242210 SGTC_2304 7443016 91.4 µM 0.716187152497086 0.229858546619577 no 824 0.236937897487956 1094 939854 SGTC_2619 obliquin 87.91 µM 0.715986144322474 0.229917713902707 no 825 0.236999952234171 1163 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1133 3473-0247 50 µM 0.714481869249419 0.230360771740352 no 826 0.237464631752749 1148 711311 SGTC_3153 9100258 49.47 µM 0.714472267073931 0.23036360142521 no 827 0.237467599527449 1117 25236848 SGTC_2603 homopterocarpin 100 µM 0.713161936456978 0.230749927684148 no 828 0.237872778455835 1182 101795 A weak amylase inhibitor. SGTC_261 5-fluorouridine 15.376 µM 0.712978408190309 0.230804066409239 no 829 0.237929559107512 1186 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2807 7945238 51.95 µM 0.711585704486815 0.231215129057022 no 830 0.23836068097717 1186 17148797 SGTC_1482 3346-2049 8.48 µM 0.704759847149676 0.233235706507129 no 831 0.24047985014349 1169 3826804 SGTC_824 1304-0008 100 µM 0.70310335045301 0.233727533194943 no 832 0.24099567216622 1175 768245 SGTC_1784 st039334 36.3 µM 0.703043124532412 0.233745425561138 no 833 0.241014437445443 1214 3496984 SGTC_1381 2324-0066 62.1 µM 0.70100598341166 0.234351081617996 no 834 0.241649640573508 1164 10885928 SGTC_2133 5320837 200 µM 0.700142334028142 0.234608112428646 no 835 0.241919210077091 1154 2841355 SGTC_2351 9026858 72.31 µM 0.699750828323435 0.234724679832344 no 836 0.24204146384412 1146 1409300 SGTC_917 harmaline 728.087 nM 0.697074286192987 0.235522454051904 no 837 0.242878152691915 1155 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_269 exalamide 29 µM 0.696293798804976 0.235755368724913 no 838 0.243122427952638 1157 3316 A derivative of salicylamide. SGTC_1096 rimcazole 32.2 µM 0.695506287726801 0.235990508093873 no 839 0.243369036057466 1135 18528119 A dopamine reuptake inhibitor. SGTC_1527 coumarin 137 µM 0.694925959569926 0.236163868329481 no 840 0.243550851561989 1193 323 A hepatotoxic, DNA x-linker. SGTC_231 b-estradiol 524 µM 0.693621075540508 0.236553929719263 no 841 0.24395993658756 1159 450 A steroid. SGTC_2122 5258151 111.688 µM 0.692189758562508 0.236982192351198 no 842 0.24440908470981 1199 2173356 SGTC_2811 7967822 32.47 µM 0.691625249869204 0.237151215427823 no 843 0.24458635032281 1200 2232244 SGTC_1206 3978-0017 132 µM 0.691619358342609 0.237152979795781 no 844 0.244588200730354 1239 3873677 SGTC_2326 6164455 177.58 µM 0.691287553137966 0.237252358969536 no 845 0.244692426101774 1183 2888790 SGTC_748 act1.228 77.9 µM 0.68869145816483 0.238030705985618 no 846 0.245508726336725 1176 4421505 YNR035C ARC35 SGTC_1857 st056007 79.3 µM 0.688531165514671 0.238078809887293 no 847 0.245559175688854 1219 619834 SGTC_2481 5478948 45.16 µM 0.688252909305799 0.238162327360447 no 848 0.245646765262664 1209 77792 SGTC_2772 vinpocetine 57.06 µM 0.687414677915354 0.238414016107625 no 849 0.245910725367101 1234 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1046 2001-0062 216 µM 0.687081574987383 0.238514074569327 no 850 0.246015662140001 1162 739778 SGTC_2264 7948757 110.76 µM 0.686170980655729 0.23878771891847 no 851 0.246302647477004 1205 2971411 SGTC_3218 9131285 49.47 µM 0.684746479889883 0.239216142478525 no 852 0.246751956670676 1229 17156417 SGTC_2727 riluzole 51.77 µM 0.682794165319236 0.239803989514024 no 853 0.247368458544578 1215 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1640 st009078 66.4 µM 0.681923375588055 0.240066440516603 no 854 0.247643701791511 1206 690618 SGTC_2572 astragaloside iv 100 µM 0.680767792460734 0.240414968264375 no 855 0.248009216274023 1228 45006101 An anti-inflammatory agent. SGTC_2426 5582046 32.21 µM 0.679590252485759 0.240770401588962 no 856 0.248381971680851 1226 2251934 SGTC_2587 piperic acid 92.2 µM 0.678935221589161 0.240968242410104 no 857 0.248589453751433 1186 5370536 SGTC_3067 9117431 49.47 µM 0.677965076910107 0.241261420305388 no 858 0.248896918166491 1221 17150885 SGTC_3004 9076122 71.4286 µM 0.677926067022177 0.241273213153171 no 859 0.248909285659739 1206 44782551 SGTC_72 0744-0168 198.391 µM 0.676628418438575 0.24166567606322 no 860 0.249320871796 1162 677577 SGTC_1942 st076330 65.2 µM 0.675554940451692 0.2419906022055 no 861 0.249661629122825 1266 24208414 SGTC_1835 st008666 49.2 µM 0.67547636406222 0.242014395436965 no 862 0.249686581573338 1166 690455 SGTC_3161 9100388 49.47 µM 0.674173332233737 0.242409143375869 no 863 0.250100560944442 1268 25236368 SGTC_2127 5253358 187.912 µM 0.67340068434749 0.242643378405937 no 864 0.250346206684241 1180 20612 SGTC_575 k072-0246 11.9 µM 0.672513711281124 0.2429124231401 no 865 0.250628357114911 1248 6796779 SGTC_2444 5485484 36.41 µM 0.672175226273793 0.243015138023684 no 866 0.250736075224848 1277 6790631 SGTC_2327 6189656 200 µM 0.670419272919904 0.243548367261518 no 867 0.251295276017032 1273 5349088 SGTC_1782 st039423 80.636 µM 0.669979011774461 0.243682160100403 no 868 0.251435584869296 1211 2068169 SGTC_1558 st069300 45.6 µM 0.66982354105421 0.243729416240603 no 869 0.251485142439384 1190 24208000 SGTC_1455 4262-0120 131 µM 0.666734671331902 0.244669319131637 no 870 0.2524708140847 1316 1529587 SGTC_25 0118-0223 35.662 µM 0.666149075869882 0.244847728042832 no 871 0.252657909417261 1278 5333628 SGTC_2251 lansoprazole 556 µM 0.666137120121741 0.244851371238804 no 872 0.252661729989958 1160 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2916 7875993 68.79 µM 0.665007255107271 0.24519579914918 no 873 0.253022926340235 1240 1299250 SGTC_1225 1216-0074 20.6 µM 0.664702733435078 0.245288674047599 no 874 0.253120322583585 1239 4241466 SGTC_2990 9074105 71.4286 µM 0.662037546910521 0.246102325502573 no 875 0.253973579466312 1220 6502001 SGTC_1631 benzylvanillin 81.9 µM 0.661005789964269 0.246417697539213 no 876 0.254304300223039 1260 75506 SGTC_2959 9079155 11 µM 0.660884730588744 0.246454715350909 no 877 0.254343119551545 1243 16189457 SGTC_2243 6634756 200 µM 0.658860716411834 0.24707406417305 no 878 0.254992606927656 1306 885676 SGTC_421 streptovitacin 30 mM 0.657242558051574 0.247569819301441 no 879 0.255512482445011 1293 91467 include heat shock SGTC_1392 3455-1037 33.9 µM 0.655231921491977 0.24818655757152 no 880 0.256159222446091 1277 981132 SGTC_1944 st076371 56.9 µM 0.654424483041115 0.248434459877147 no 881 0.256419182581624 1236 24208455 SGTC_2961 9083290 32.55 µM 0.653913291886962 0.248591475596263 no 882 0.256583834982882 1240 17741490 SGTC_2134 5324836 1.464 µM 0.653085852937045 0.248845740898499 no 883 0.256850466050292 1234 699272 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.651928147483307 0.24920172665854 no 884 0.257223762923613 1216 4620898 SGTC_2395 5646831 180.19 µM 0.651721175556917 0.249265397501371 no 885 0.257290529789234 1295 6808628 SGTC_508 roscovitine 141 µM 0.650441376665132 0.249659294493008 no 886 0.257703578794279 1310 160355 A CDKinase inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.650217396290895 0.249728265235299 no 887 0.257775902773945 1361 5282309 SGTC_2205 7238770 200 µM 0.650004282448507 0.249793899216454 no 888 0.25784472769529 1292 279867 SGTC_1726 st035556 14.5795 µM 0.64953552311248 0.249938298134911 no 889 0.257996146644363 1341 5919439 SGTC_881 0833-0569 170 µM 0.64913567243229 0.250061505096348 no 890 0.258125343115987 1245 5418700 SGTC_3271 9137798 49.47 µM 0.644547523360354 0.251477565738498 no 891 0.259610225580607 1213 6498326 SGTC_2941 9056145 11.23 µM 0.644297190304959 0.251554948856429 no 892 0.259691368629364 1176 2119517 SGTC_2488 5268135 45.7 µM 0.64158920462486 0.252392846639958 no 893 0.26056997207739 1299 1270356 YLR208W SEC13 SGTC_1079 idarubicin 2.36 µM 0.641419105101475 0.252445527445422 no 894 0.260625211748416 1258 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3262 9137218 49.47 µM 0.641027640615235 0.252566788269699 no 895 0.260752362392241 1158 17650664 SGTC_2052 5265182 7.135 µM 0.638098326456225 0.253475151545291 no 896 0.261704837954013 1316 1239884 SGTC_2944 9067346 25.62 µM 0.637043548109601 0.253802652031872 no 897 0.262048239007097 1259 6473075 SGTC_2110 5483698 200 µM 0.636935146486441 0.253836322477937 no 898 0.262083544085402 1292 2848765 YHR062C RPP1 SGTC_3298 9116858 71.43 µM 0.636910629793039 0.253843937892002 no 899 0.26209152920958 1315 2506942 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.636618306883169 0.253934748935719 no 900 0.262186748830017 1153 6708630 An antioxidant. SGTC_406 estrone 100 µM 0.636617601552502 0.253934968069555 no 901 0.262186978601895 1339 5870 A steroid. SGTC_2879 9041815 71.43 µM 0.636517546483727 0.253966054425562 no 902 0.262219574063058 1234 4942971 SGTC_1506 4226-2149 212 µM 0.634578360899009 0.254568938958019 no 903 0.26285172243663 1332 991114 SGTC_2507 purpurin 79.67 µM 0.633674367734856 0.254850242571362 no 904 0.263146678120847 1272 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.633125687470841 0.255021059613107 no 905 0.263325784430207 1287 5106787 A p450 inhibitor. SGTC_654 1124-0271 80.9 µM 0.629420073223713 0.256176270728773 no 906 0.264537039938261 1289 5403748 SGTC_1923 st058458 19.1 µM 0.627387264221673 0.256811148234401 no 907 0.265202706999547 1385 3534982 SGTC_2091 4-phenylthiadiazole 200 µM 0.626910956334983 0.256960024844825 no 908 0.265358802487727 1301 270010 SGTC_1153 4055-0057 267 µM 0.626054543627542 0.257227821372301 no 909 0.265639583071887 1282 882706 SGTC_705 1124-0212 310 µM 0.624548834414392 0.257699001635785 no 910 0.266133604855342 1311 9554485 SGTC_3239 9133757 49.47 µM 0.622715687614801 0.258273250896072 no 911 0.26673568593162 1320 17036923 SGTC_1354 1498-1681 81 µM 0.62243147939506 0.258362340951626 no 912 0.266829093247339 1342 5754243 SGTC_1172 0370-0043 85 µM 0.62205552541504 0.258480214785092 no 913 0.266952678931871 1356 376585 SGTC_3107 9121808 49.47 µM 0.621422402613759 0.258678782367005 no 914 0.267160867904407 1260 662681 SGTC_2646 retinol 96.75 µM 0.621352340479632 0.258700760947351 no 915 0.267183911383176 1314 445354 A vitamin A analog and teratogen. SGTC_516 3992-2719 87.3 µM 0.621064324316437 0.258791122136728 no 916 0.267278650613115 1237 5350887 YDR037W KRS1 SGTC_2007 4011539 71.82 µM 0.620208862182675 0.259059608124085 no 917 0.267560143840382 1340 45595301 SGTC_3183 9108214 49.47 µM 0.618351874492843 0.259642917263452 no 918 0.268171706992057 1241 4974831 SGTC_1092 toremifene 6.32 µM 0.618001109606679 0.259753174130148 no 919 0.268287303591012 1322 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_121 0557-0495 61.343 µM 0.617899312054065 0.259785176950687 no 920 0.268320856256138 1405 3104427 SGTC_2886 9058944 51.95 µM 0.617783247230575 0.25982166755675 no 921 0.268359114015593 1208 4949929 SGTC_3279 9140807 49.47 µM 0.61753397652732 0.259900046829266 no 922 0.268441288911463 1340 45595718 SGTC_515 4092-1064 102 µM 0.616734337881122 0.260151562983327 no 923 0.268704984166572 1373 717353 SGTC_2335 9018011 154.17 µM 0.616699049985454 0.260162665231367 no 924 0.268716623983713 1352 6458208 SGTC_1691 st019933 84.6 µM 0.615490716867051 0.26054297728119 no 925 0.269115349031918 1308 6176082 SGTC_219 mitoxanthrone 164.414 µM 0.615336869162508 0.260591420005382 no 926 0.269166136903588 1336 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2867 9039098 71.43 µM 0.615259579531381 0.2606157582916 no 927 0.269191653404123 1290 6463460 SGTC_1023 4482-3888 16 µM 0.61336200633529 0.261213665521622 no 928 0.269818501087417 1362 3303168 SGTC_2081 5214970 32.255 µM 0.610765645478321 0.262032894573741 no 929 0.27067736999583 1305 2063512 SGTC_3031 9088762 49.47 µM 0.610723478710553 0.262046210303075 no 930 0.270691329902669 1287 205253 SGTC_2387 9077560 195.08 µM 0.609643588990993 0.262387343896994 no 931 0.271048965172312 1289 5303272 SGTC_2721 ifenprodil 61.44 µM 0.608999821115443 0.262590816177942 no 932 0.271262278734309 1336 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.607095145218459 0.263193289445066 no 933 0.27189388590839 1300 688667 SGTC_1846 st056244 14.8 µM 0.606557257135535 0.263363558077089 no 934 0.272072386685395 1359 5393182 SGTC_2910 7948405 25.97 µM 0.604540049570382 0.264002606307175 no 935 0.272742325384382 1324 2971328 SGTC_1765 st044815 90.4 µM 0.603484458945008 0.26433733045564 no 936 0.273093225551694 1284 645695 SGTC_2228 7354201 200 µM 0.602107554801927 0.264774266495303 no 937 0.27355127300427 1356 753451 SGTC_1071 trifluoperazine 6.31 µM 0.601455499237251 0.264981312780629 no 938 0.273768321482931 1392 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1737 st035557 69.7 µM 0.601302979409996 0.265029754055744 no 939 0.273819102752321 1304 5716916 SGTC_2346 9031566 143.75 µM 0.600389373746566 0.265320015231226 no 940 0.274123383996342 1341 4771086 SGTC_1123 mangostin 811.285 nM 0.597809861363632 0.266140420813885 no 941 0.274983404967804 1337 5281650 An antioxidant. SGTC_1336 1486-0901 104 µM 0.597239778898003 0.266321906856131 no 942 0.275173652215461 1378 5006114 SGTC_1313 1220-0047 237 µM 0.596874917016533 0.266438093681894 no 943 0.275295447495147 1395 3528706 SGTC_1085 doxorubicin 7.67 µM 0.596119596125968 0.266678699958335 no 944 0.275547666970523 1372 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2743 auranofin 4.32 µM 0.59609765486051 0.266685690955134 no 945 0.275554995375216 1318 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_527 4476-4215 268 µM 0.595830744064792 0.266770742351824 no 946 0.275644151523319 1367 4418754 SGTC_1653 st012112 65 µM 0.595774686733682 0.266788606819129 no 947 0.275662878141909 1364 720429 SGTC_452 diindolylmethane 8 µM 0.595219841483924 0.266965458660534 no 948 0.275848264525744 1353 3071 Inhibits expression of several cancer promoting factors. SGTC_1193 1488-0126 41.5 µM 0.59449613300322 0.267196223062468 no 949 0.276090163965244 1342 1384710 SGTC_3351 9150312 21.596 µM 0.593770249615243 0.267427782053806 no 950 0.276332894934442 1343 4904905 SGTC_3225 9130819 49.47 µM 0.593066322956926 0.267652433410252 no 951 0.276568383649768 1383 4547121 SGTC_970 1315-0089 19.5 µM 0.59102692635005 0.268303823559346 no 952 0.277251189810416 1280 6811083 YLR033W RSC58 SGTC_1389 3405-0187 19 µM 0.590522176056196 0.268465165525066 no 953 0.277420311415704 1304 799890 SGTC_3338 9144300 39.5675 µM 0.588287964610042 0.269179910052962 no 954 0.278169511278079 1369 4901274 SGTC_2740 felodipine 17.08 µM 0.586051467122538 0.269896340743795 no 955 0.278920464597613 1385 3333 L-type calcium channel blocker SGTC_2311 7694451 200 µM 0.585556285659768 0.270055094165184 no 956 0.279086865950075 1388 2163142 SGTC_2491 paeonol 100 µM 0.584355185608599 0.270440356579889 no 957 0.279490685429942 1309 11092 Increases levels of cortical cytochrome oxidase. SGTC_2956 9076196 2.52 µM 0.584350870680648 0.270441741122396 no 958 0.279492136654704 1393 16423868 SGTC_3018 9082602 49.47 µM 0.582809703285185 0.270936486099355 no 959 0.280010706063386 1354 17332089 SGTC_2606 farnesol 9.78 µM 0.580811763749197 0.271578535391984 no 960 0.280683662897737 1422 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_71 0417-1750 47.813 µM 0.579484345137335 0.272005527463826 no 961 0.281131203371351 1461 6811472 SGTC_1990 st072050 59.8 µM 0.577791639736557 0.272550505580134 no 962 0.281702400155522 1360 17233948 SGTC_1214 0358-0031 63.7 µM 0.577596570329666 0.272613344331461 no 963 0.281768261497585 1557 4301366 SGTC_2688 kanamycin b 96.69 µM 0.576833348683753 0.272859274092498 no 964 0.282026019553623 1413 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_480 am 92016 50 µM 0.575183476253765 0.273391281435014 no 965 0.282583608365318 1301 2129 K+ channel blocker. SGTC_70 0141-0289 43.283 µM 0.574379477040736 0.273650719895398 no 966 0.282855518837621 1475 352408 SGTC_560 2332-1943 155 µM 0.572188151669738 0.274358445482459 no 967 0.283597256776414 1376 21177716 SGTC_3293 9120939 62.045 µM 0.571075502021963 0.274718140043743 no 968 0.283974232005212 1411 934087 SGTC_13 0199-0087 65 µM 0.569345862464708 0.275277754829412 no 969 0.284560724334361 1400 4589825 SGTC_3274 9138298 49.47 µM 0.569006443686549 0.275387637617415 no 970 0.28467588352018 1347 17015756 SGTC_33 0986-0033 35.816 µM 0.568540546922102 0.275538501282606 no 971 0.284833990816038 1373 2848082 SGTC_671 0560-0003 407 µM 0.568377164938706 0.275591416200292 no 972 0.284889446246656 1381 3238678 SGTC_2106 5357045 167.29 µM 0.567987839464257 0.275717528119163 no 973 0.285021612612146 1453 668842 SGTC_2812 7970281 58.44 µM 0.567142863985742 0.275991333625065 no 974 0.285308561422816 1483 2233435 SGTC_834 0312-0008 75.7 µM 0.566967763857963 0.276048089696746 no 975 0.285368041627954 1397 6385573 YIL048W NEO1 SGTC_1377 2944-0135 198 µM 0.566528497177471 0.27619049659837 no 976 0.285517283223718 1456 1894137 SGTC_2951 9072950 58.06 µM 0.565358065683017 0.276570117481052 no 977 0.285915120587311 1371 16488155 SGTC_1807 st050092 58.9 µM 0.565306470659802 0.276586857833245 no 978 0.285932664137969 1361 5008496 SGTC_2207 7258803 200 µM 0.564075624414062 0.276986361361343 no 979 0.286351333145961 1381 3666799 SGTC_335 4077-0256 27.6 µM 0.563440784002079 0.277192525884265 no 980 0.286567386080837 1406 3121989 SGTC_2200 6600604 21.907 µM 0.56183846811685 0.27771321183262 no 981 0.287113040044835 1348 2904777 SGTC_1420 4'-methoxyflavone 42 µM 0.559144942346213 0.278589570551214 no 982 0.288031402453539 1405 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_271 rotenone 740 µM 0.557267598434335 0.279201173862553 no 983 0.288672305049877 1426 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1260 0700-1617 7.75 µM 0.556521723309116 0.279444346964494 no 984 0.288927124132354 1426 2853078 SGTC_2142 5622915 118.518 µM 0.554174146872987 0.280210383621845 no 985 0.289729834864161 1380 5322196 SGTC_2005 4024620 188 µM 0.551092436966812 0.2812175167742 no 986 0.290785154846304 1392 236743 SGTC_2476 5806916 10.51 µM 0.55057607851856 0.281386438621741 no 987 0.290962155506197 1397 2870194 SGTC_576 1073-0113 22.7 µM 0.549746435371132 0.281657951139645 no 988 0.291246651282652 1514 5439563 SGTC_677 0929-0063 136 µM 0.548870249361928 0.281944832552669 no 989 0.291547248140591 1386 1539583 SGTC_2694 st077685 81.9 µM 0.548770918257387 0.281977364491074 no 990 0.291581335213198 1351 2838096 SGTC_1525 8-methoxypsoralen 92.5 µM 0.5478257215041 0.282287016383747 no 991 0.29190578767457 1535 4114 Related to psoralen; DNA damaging agent. SGTC_87 0100-0052 35.5 µM 0.5459330704046 0.282907551158456 no 992 0.292555972486588 1483 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2790 5423970 71.43 µM 0.545567476605354 0.283027492150798 no 993 0.292681642893469 1515 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1797 st048695 56.8 µM 0.542796434095337 0.283937385606658 no 994 0.293634984341583 1452 592262 YIL048W NEO1 SGTC_341 1486-1430 230 µM 0.54165912511046 0.284311234644816 no 995 0.294026676475123 1381 2054753 YPL210C SRP72 SGTC_2768 sulfasalazine 50.2 µM 0.538582517899223 0.285323734934353 no 996 0.295087476508146 1554 5384001 An antioxidant and salicylic acid derivative. SGTC_1283 0922-0125 16.4 µM 0.538096464229359 0.285483850410581 no 997 0.295255226680887 1500 3360884 SGTC_896 0964-0007 44.5 µM 0.536280870121249 0.28608232024023 no 998 0.295882224813563 1412 6756758 SGTC_549 1661-1316 519 µM 0.534703481880743 0.286602754281785 no 999 0.296427456710713 1510 2857282 SGTC_1184 1269-1718 139 µM 0.534541423121709 0.286656248406289 no 1000 0.296483499184415 1534 5403821 SGTC_506 n9-isopropylolomoucine 153 µM 0.53191482109288 0.287523925441938 no 1001 0.297392495855078 1533 6610355 SGTC_2741 miltefosine 3.04 µM 0.531321015155742 0.28772025646412 no 1002 0.297598172491968 1398 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1965 Pectolinarigenin 58.4 µM 0.53081392714911 0.287887965923488 no 1003 0.297773864006931 1418 5320438 An anti-inflammatory. SGTC_1 0258-0098 57.368 µM 0.530128792078626 0.28811463426843 no 1004 0.298011318862376 1396 6790032 YDR047W HEM12 SGTC_579 4491-1009 110 µM 0.528600040196718 0.288620706017465 no 1005 0.298541466204639 1535 1271041 SGTC_505 gw-5074 63.9 µM 0.527885177074647 0.288857494964902 no 1006 0.298789516718751 1494 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1361 1608-0041 5.61 µM 0.527049204439671 0.289134515762847 no 1007 0.299079709802186 1404 X1361 SGTC_1521 st012942 49.4 µM 0.526597795182774 0.289284153625676 no 1008 0.299236461707091 1595 24207259 SGTC_797 k781-0471 270 µM 0.5258534497448 0.289530976496953 no 1009 0.299495017104075 1501 23738129 SGTC_2078 5212016 200 µM 0.525377682285975 0.289688791447121 no 1010 0.299660332444049 1436 1899708 SGTC_711 k292-0785 179 µM 0.524495620522394 0.289981483440884 no 1011 0.299966932540066 1423 4146315 SGTC_907 3448-6986 75.5 µM 0.521924973290357 0.290835283752223 no 1012 0.300861284820157 1544 590582 SGTC_1247 0448-0043 5.84 µM 0.521852158955609 0.290859485001423 no 1013 0.300886635117782 1464 3089013 YGL099W LSG1 SGTC_3054 9094397 49.47 µM 0.521248516205222 0.291060153558104 no 1014 0.301096830318984 1389 2598354 SGTC_626 0214-0009 33 µM 0.520645737166208 0.291260599498394 no 1015 0.301306790772167 1549 3437874 SGTC_2320 7373003 200 µM 0.518173941211405 0.292083234612682 no 1016 0.302168457236101 1389 5415828 SGTC_2325 6158266 200 µM 0.51649599138066 0.292642286375331 no 1017 0.302754018981795 1452 3623240 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.516085579190672 0.292779101280823 no 1018 0.302897319703376 1522 688798 SGTC_2701 st077767 14.721 µM 0.515823127896434 0.292866607544727 no 1019 0.302988973879228 1426 5721188 SGTC_1107 amlodipine 47 µM 0.513400683772696 0.293674869141053 no 1020 0.303835533692164 1399 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_131 0141-0277 33.849 µM 0.513109092951386 0.293772229576906 no 1021 0.303937505634125 1525 1547771 SGTC_1011 4112-3381 17.4 µM 0.512937257813953 0.293829611297212 no 1022 0.30399760507814 1503 2877139 SGTC_23 0213-0011 39.996 µM 0.510637623333235 0.294598037630121 no 1023 0.304802412949536 1531 627608 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.510363995287156 0.294689532543063 no 1024 0.30489823814149 1511 6708739 YPR165W RHO1 SGTC_2368 9071271 200 µM 0.510319157957012 0.294704526362624 no 1025 0.304913941557342 1427 27209959 SGTC_3169 9102970 49.47 µM 0.509472940150633 0.294987571635606 no 1026 0.305210380489577 1506 17027839 SGTC_448 monastrol 171 µM 0.509111276442563 0.29510858010414 no 1027 0.305337114062741 1493 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_326 k292-0812 17.5 µM 0.508039921849784 0.295467176974241 no 1028 0.305712673205441 1500 3579357 SGTC_254 nsc-64875 3.808 µM 0.507680797865891 0.295587425461558 no 1029 0.305838608479642 1593 56993 SGTC_810 3825-7150 143 µM 0.503664359987857 0.296933813112243 no 1030 0.307248628633485 1626 22330411 YGL099W LSG1 SGTC_73 0327-0325 16.231 µM 0.503513868177931 0.296984315370768 no 1031 0.307301516245382 1497 53298 SGTC_1251 0490-5699 265 µM 0.503158956687761 0.297103432637205 no 1032 0.307426259308368 1567 3883818 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.502637770225461 0.297278395570684 no 1033 0.307609484499171 1537 5377381 SGTC_1819 st053448 58.6 µM 0.499073541532585 0.298476171398084 no 1034 0.308863788140684 1508 2857616 SGTC_3190 9110366 49.47 µM 0.498702752358618 0.298600902841491 no 1035 0.308994402663025 1551 17123768 SGTC_2669 eugenol 100 µM 0.497259655412418 0.2990865782433 no 1036 0.309502979089525 1514 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_861 0443-0273 110 µM 0.497125177958816 0.299131854996004 no 1037 0.309550390260258 1510 6149169 SGTC_1739 st037196 92.5 µM 0.496262344630008 0.299422433380299 no 1038 0.309854664877432 1570 612214 SGTC_3037 9091026 49.47 µM 0.496142609973955 0.29946276680922 no 1039 0.309896899110909 1495 25236398 YIL048W NEO1 SGTC_1302 1159-0335 255 µM 0.491677117987933 0.300968753386408 no 1040 0.311473808356019 1480 649284 SGTC_1550 gossypolone 36.6 µM 0.490295314068611 0.301435457424375 no 1041 0.311962471207637 1486 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2424 5537928 59.2 µM 0.488897454912243 0.301907915261262 no 1042 0.312457148821983 1478 5382802 SGTC_1276 0871-0068 94.2 µM 0.488578741601653 0.302015682689206 no 1043 0.312569983191285 1559 3414906 SGTC_1916 st067606 49.2 µM 0.488196934879666 0.302144806810367 no 1044 0.312705177712479 1601 19590279 SGTC_992 3909-8734 162 µM 0.487600744123145 0.302346483522274 no 1045 0.312916334197517 1486 4288319 SGTC_2927 9011802 47.9 µM 0.483384463171635 0.303774468037003 no 1046 0.314411388927634 1439 43912568 SGTC_300 r073-0011 5.04 µM 0.481990731828981 0.304247162677008 no 1047 0.31490626511018 1517 2735780 SGTC_225 nsc-122657 1.016 µM 0.481890363601122 0.304281215971351 no 1048 0.31494191598987 1511 275685 SGTC_2139 5578692 56.4705 µM 0.48010413239853 0.304887538605651 no 1049 0.315576674986582 1574 650991 YMR113W FOL3 SGTC_819 1013-0258 27.7 µM 0.477143387231278 0.305893721495328 no 1050 0.316630010507589 1500 5753198 SGTC_1164 k060-0068 93.7 µM 0.474863547039027 0.306669505024185 no 1051 0.317442117647619 1543 5963676 SGTC_1861 st057647 17.4 µM 0.473338016720523 0.30718909654571 no 1052 0.317986021774712 1628 688668 SGTC_893 0958-0369 48.9 µM 0.472973517946248 0.307313301217014 no 1053 0.318116036336911 1626 6819948 SGTC_2773 thioridazine 9.09 µM 0.472548557218054 0.307458136490525 no 1054 0.318267645622517 1530 5452 An antipsychotic. SGTC_2291 7917025 104.35 µM 0.471157706382071 0.307932376651575 no 1055 0.318764059329746 1473 2964612 SGTC_93 0109-0045 59.227 µM 0.469234298553437 0.308588732199788 no 1056 0.319451085928575 1537 88733 SGTC_1358 1509-0022 2.48 µM 0.469232387499946 0.308589384644171 no 1057 0.319451768851111 1520 3258434 SGTC_2531 methyl deoxycholate 70.07 µM 0.468916728336895 0.308697160745881 no 1058 0.319564579306756 1489 16667744 Haematoxylin. SGTC_855 0428-0020 25 µM 0.468149249983879 0.308959271054481 no 1059 0.319838930809566 1517 6812414 SGTC_2854 9024559 71.43 µM 0.465325901746421 0.309924341632102 no 1060 0.320849044332561 1489 3163529 SGTC_685 1278-0033 54.9 µM 0.463972816642138 0.310387315374403 no 1061 0.321333610708168 1605 3590572 SGTC_1418 3966-3099 2.4 µM 0.461380704073375 0.311275075795206 no 1062 0.322262746446378 1593 740335 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.459198022865735 0.312023464520609 no 1063 0.323045985123231 1573 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_856 0433-0016 11.3 µM 0.459098474420869 0.312057615820153 no 1064 0.323081726081375 1542 3911780 SGTC_1419 3993-2473 62.6 µM 0.458213192076453 0.312361393682226 no 1065 0.323399641536069 1573 704026 SGTC_1534 6-azauridine 81.6 µM 0.45738923104792 0.312644244243184 no 1066 0.323695651673881 1536 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2375 9072683 200 µM 0.457234414610085 0.312697402182017 no 1067 0.323751282337737 1682 16798029 SGTC_1677 st019204 53.9 µM 0.45593356466354 0.313144217237939 no 1068 0.324218876187172 1485 3945625 SGTC_2849 9019321 12.99 µM 0.455344537916466 0.313346626075635 no 1069 0.324430694644918 1550 16489627 SGTC_2367 9070478 135.38 µM 0.45476776954005 0.313544877030547 no 1070 0.324638159958625 1543 572802 SGTC_179 1273-0063 6.77 µM 0.452773795860915 0.314230674704316 no 1071 0.325355817234924 1498 3108139 SGTC_2657 nystatin 74.44 µM 0.45239739532566 0.314360204170369 no 1072 0.325491361522321 1599 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1929 genistein trimethyl ether 50.5 µM 0.451766570865268 0.314577338952547 no 1073 0.325718577276495 1722 136420 SGTC_2556 citropten 84.59 µM 0.451280887983212 0.314744558563292 no 1074 0.325893558823858 1508 2775 A potential DNA crosslinker. SGTC_48 0382-0018 55 µM 0.449961289025532 0.315199085539189 no 1075 0.326369176759515 1689 762596 SGTC_1045 1348-1485 165 µM 0.447740048359332 0.315964808806667 no 1076 0.327170407538093 1533 6810614 SGTC_15 0266-0086 27.098 µM 0.447490139786088 0.316051008740897 no 1077 0.32726060280681 1612 1712902 YIL048W NEO1 SGTC_3151 9099821 49.47 µM 0.447020400429549 0.316213061065178 no 1078 0.327430165173029 1510 17174189 SGTC_1889 st059080 5.18 µM 0.445399082566412 0.316772660058782 no 1079 0.328015687552798 1691 176925 Isolated from Daphnopsis sellowiana. SGTC_2130 NSC 7 2.4545 µM 0.444342730828311 0.317137486405365 no 1080 0.328397405837455 1678 21448 SGTC_927 2425-1185 123 µM 0.442653618008378 0.317721215299915 no 1081 0.329008147932729 1507 730375 SGTC_963 1269-2853 151 µM 0.442102586636562 0.317911740591844 no 1082 0.329207486357561 1524 3668223 SGTC_870 0573-2213 57.6 µM 0.439392968267645 0.318849322245657 no 1083 0.330188410372003 1528 3916321 SGTC_2307 7538926 6.34 µM 0.439032294230127 0.31897421025802 no 1084 0.330319068238676 1559 96582 SGTC_2173 5763948 167 µM 0.438308864095375 0.319224769171596 no 1085 0.330581200577548 1573 2867177 SGTC_2909 7941780 10.49 µM 0.437681343118279 0.319442176997616 no 1086 0.330808647908258 1671 1243215 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.437664227932303 0.319448107510678 no 1087 0.330814852247167 1579 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_493 zm226600 134 µM 0.437363224741622 0.319552414441931 no 1088 0.330923974975664 1589 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2593 nobiletin 86.24 µM 0.436410967909719 0.319882494936995 no 1089 0.331269291358527 1531 72344 An anti-infammatory. SGTC_2459 5811157 9.22 µM 0.436352557220488 0.319902746462884 no 1090 0.331290477470114 1540 2870684 YBR192W RIM2 SGTC_859 0439-0102 54.6 µM 0.435132397131383 0.320325909888181 no 1091 0.331733164487371 1658 610143 SGTC_209 4077-0173 175.592 µM 0.435104548889584 0.320335570660491 no 1092 0.331743270870905 1577 15993494 SGTC_1324 1418-0026 34.4 µM 0.434166735418913 0.320660976528652 no 1093 0.332083683479667 1604 1372513 SGTC_2252 omeprazole 400 µM 0.431177691650304 0.321699044636136 no 1094 0.333169586663768 1652 4594 A proton pump inhibitor. SGTC_1753 st043925 64 µM 0.430172165014648 0.322048568671846 no 1095 0.333535204156237 1646 670181 SGTC_1248 0469-0687 58.6 µM 0.429718684327949 0.322206251440245 no 1096 0.333700145118787 1660 4017482 SGTC_1349 flufenamic acid 69 µM 0.429585195386469 0.322252673861019 no 1097 0.333748704126415 1554 3371 A non-steroidal anti-inflammatory. SGTC_2918 7977171 22.06 µM 0.428960103451611 0.322470094147812 no 1098 0.333976129620093 1554 2236483 SGTC_2469 5655019 90.81 µM 0.42864761430552 0.322578807301375 no 1099 0.334089844563994 1705 2788239 SGTC_100 0086-0128 49.5915 µM 0.427383480649421 0.323018746769831 no 1100 0.334550018742928 1487 93297 SGTC_159 3970-0959 50 µM 0.427037882644278 0.323139063749289 no 1101 0.334675867801906 1638 6615653 SGTC_2061 5245884 80.95 µM 0.425462541242638 0.323687739610321 no 1102 0.335249761423725 1578 573863 SGTC_210 3551-0445 56.827 µM 0.425461782933334 0.323688003814393 no 1103 0.335250037766988 1621 2865180 YOR207C RET1 SGTC_876 0720-0963 56.8 µM 0.425288486262132 0.323748384787115 no 1104 0.335313192920405 1717 765861 SGTC_2628 lathosterol 100 µM 0.424662028652603 0.323966697258962 no 1105 0.335541534023771 1609 6710616 SGTC_1865 st057639 52.2 µM 0.42226652175045 0.324802058833999 no 1106 0.336415245683111 1580 688818 SGTC_133 0724-0033 378.92 µM 0.421501465887522 0.32506903524077 no 1107 0.336694470499045 1539 280309 SGTC_2824 7998404 51.95 µM 0.419788688440458 0.325667057238291 no 1108 0.337319914497853 1616 837851 SGTC_1634 st006576 41 µM 0.419515905121321 0.325762341933517 no 1109 0.337419566607439 1730 3915356 SGTC_1353 1498-1206 8.11 µM 0.419489331483716 0.325771624858066 no 1110 0.337429274992004 1574 6756808 SGTC_1959 st077091 55.8 µM 0.4194421151797 0.325788119117368 no 1111 0.337446525213387 1568 821356 YKL052C ASK1 SGTC_2071 5230951 39.92 µM 0.418965894153197 0.325954498363055 no 1112 0.337620529084735 1611 1799272 SGTC_1493 4348-0038 111 µM 0.417015974093365 0.326636110958035 no 1113 0.338333361806676 1652 800424 SGTC_1412 3909-8563 178 µM 0.415468979528729 0.327177289340259 no 1114 0.338899309591895 1716 23767530 SGTC_2649 anisomycin 9.56 µM 0.413894425927582 0.327728481926027 no 1115 0.339475713132782 1598 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2435 5706476 10.6 µM 0.413767195423995 0.327773037003643 no 1116 0.339522305369188 1729 5725375 SGTC_740 k014-0057 261 µM 0.412453878529626 0.328233092983419 no 1117 0.340003389636117 1728 4012779 SGTC_357 1325-0123 420 µM 0.411290012431697 0.328641014104008 no 1118 0.340429946103673 1702 1098503 SGTC_3146 9095609 49.47 µM 0.410941895637776 0.328763064579272 no 1119 0.340557570473268 1673 17173999 SGTC_2532 xanthone 78.9 µM 0.40946215972216 0.329282066786278 no 1120 0.341100265466085 1678 7020 An insecticide. SGTC_2640 pentamidine 10.38 µM 0.405728687602013 0.33059300493373 no 1121 0.342470980644657 1753 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2013 4024628 200 µM 0.40448430216256 0.331030410574649 no 1122 0.342928309551594 1656 5230760 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.403154697149751 0.331498026149584 no 1123 0.34341721225799 1749 688664 SGTC_2467 5474540 200 µM 0.401600589092111 0.332044931401726 no 1124 0.343988998124638 1583 5413519 SGTC_553 k007-0256 45.7 µM 0.40125203921394 0.332167638572774 no 1125 0.344117285294058 1645 6287000 SGTC_589 1227-0070 34.1 µM 0.401007855494421 0.332253614303239 no 1126 0.344207170173855 1645 2841384 SGTC_1231 0242-0792 125 µM 0.398938659256793 0.332982520814528 no 1127 0.344969201399576 1595 3707635 SGTC_900 1112-0045 141 µM 0.398239911340815 0.333228808397209 no 1128 0.345226674379553 1584 56211 YIL048W NEO1 SGTC_1730 st033808 45.1 µM 0.398039801571743 0.333299354314466 no 1129 0.345300423557899 1628 1045166 SGTC_637 1181-0519 7.26 µM 0.398021254994034 0.333305892951272 no 1130 0.345307259078253 1605 6252091 YGR060W ERG25 SGTC_2399 5884133 200 µM 0.397374749709493 0.333533851461066 no 1131 0.345545566367901 1580 722445 SGTC_1719 st032227 49.2 µM 0.395782277346999 0.334095621140794 no 1132 0.346132826074059 1572 3125804 SGTC_2881 9058953 51.95 µM 0.395444869174723 0.334214694970183 no 1133 0.346257300440699 1553 17122249 SGTC_2043 5101342 149 µM 0.393439463384306 0.334922761417333 no 1134 0.346997463655579 1648 678451 SGTC_2386 9075165 157.42 µM 0.392540999452526 0.335240180692914 no 1135 0.34732926198408 1651 16452277 SGTC_460 trequinsin 123 µM 0.391850134642582 0.335484337102391 no 1136 0.347584474585565 1654 5537 A vasodilator. SGTC_3066 9117245 49.47 µM 0.391650127848138 0.335555033864352 no 1137 0.347658372065098 1735 17176980 SGTC_2998 9066762 71.4286 µM 0.390823572919208 0.335847259447719 no 1138 0.347963824686413 1735 4945196 SGTC_2475 5812728 15.03 µM 0.390592033295052 0.335929137273659 no 1139 0.348049407645971 1598 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_732 3970-1727 52.7 µM 0.389568104683827 0.336291315693679 no 1140 0.348427970563326 1775 1275699 SGTC_1841 st054148 70 µM 0.389100343221957 0.33645682031238 no 1141 0.348600959796956 1590 675442 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.389037773694721 0.336478961234642 no 1142 0.348624101873934 1542 5711223 A potent inhibitor of glutathione S-transferases. SGTC_942 3253-1115 227 µM 0.389011009959853 0.33648843205267 no 1143 0.348634000928682 1741 46497897 SGTC_2336 9001819 198.65 µM 0.388838069520994 0.336549632567502 no 1144 0.348697968583882 1730 2989602 SGTC_2594 a-mangostin 100 µM 0.386981404202767 0.337206945563494 no 1145 0.34938498740008 1768 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2630 antimycin a 100 µM 0.386866749201985 0.337247553057726 no 1146 0.349427429210532 1576 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2775 cyproheptadine 69.59 µM 0.386632623293699 0.33733047959007 no 1147 0.349514101380954 1682 2913 A selective serotonin reuptake inhibitor. SGTC_174 3553-0389 74.3 µM 0.384501117127214 0.338085814250823 no 1148 0.350303534035893 1697 738071 SGTC_1080 nisoldipine 24.4 µM 0.383638616972074 0.338391641069642 no 1149 0.350623156959664 1644 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_83 0170-0301 39.027 µM 0.383347468525744 0.338494901079793 no 1150 0.350731073836171 1679 3089716 SGTC_3050 9093513 49.47 µM 0.383167940658855 0.338558579289512 no 1151 0.350797623512068 1634 25236664 SGTC_1056 3448-1962 115 µM 0.38303759739217 0.338604814702862 no 1152 0.350845943682644 1681 715507 SGTC_2390 9097792 176.6 µM 0.382446610173874 0.338814480424978 no 1153 0.351065061614236 1584 4497149 SGTC_2582 agaric acid 100 µM 0.380406931302594 0.339538484738874 no 1154 0.351821685125311 1590 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_593 1203-0218 61.7 µM 0.377317995991613 0.340636060695373 no 1155 0.352968650001212 1762 3666956 SGTC_833 3852-0053 558 µM 0.377284431407335 0.340647994466507 no 1156 0.352981120363793 1719 3123681 SGTC_3215 9129942 49.47 µM 0.374108504755391 0.341777904274679 no 1157 0.354161795750577 1787 17682944 SGTC_653 0203-0016 55.2 µM 0.372681260895635 0.342286142231431 no 1158 0.354692842478475 1710 295302 SGTC_163 TUB2.036 7.546 µM 0.37150250904169 0.342706108343752 no 1159 0.355131643755314 1699 15992207 YJR013W GPI14 SGTC_113 0099-0221 2.5 µM 0.369294071164047 0.343493454527505 no 1160 0.355954272128011 1774 89219 SGTC_2116 5511452 16.8835 µM 0.36887381207889 0.343643361207161 no 1161 0.356110891953168 1694 870744 SGTC_999 SEC7.066 22.7 µM 0.368452366092146 0.343793715951869 no 1162 0.356267978490654 1724 740511 YDR170C SEC7 SGTC_1387 3342-1166 1.8 µM 0.368241398448591 0.343868989887464 no 1163 0.356346622112122 1696 3418228 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.368044306614437 0.34393931848162 no 1164 0.356420098688654 1756 6710655 SGTC_2515 chrysin 20.77 µM 0.367822654947375 0.344018417251064 no 1165 0.356502737630818 1749 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_32 0928-0142 34.1 µM 0.367356683971737 0.344184726236472 no 1166 0.356676488715043 1742 2244242 SGTC_3177 9107506 49.47 µM 0.364429326791518 0.345230213093198 no 1167 0.357768719658415 1770 8897194 SGTC_3116 9124943 49.47 µM 0.364170507073274 0.345322705895746 no 1168 0.357865344512849 1595 41905195 YPL160W CDC60 SGTC_2876 9059903 25.97 µM 0.362717446758065 0.34584214846507 no 1169 0.35840798271408 1683 6916095 SGTC_2754 granisetron 64.02 µM 0.362002918990776 0.346097685650239 no 1170 0.358674924567281 1808 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1064 honokiol 6.76 µM 0.360931535037275 0.346480976945385 no 1171 0.359075314399603 1694 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_613 3914-0030 117 µM 0.360181755548534 0.346749306689759 no 1172 0.359355608678542 1695 1145395 SGTC_1221 2958-7315 257 µM 0.359830031520617 0.34687520756063 no 1173 0.359487121743124 1712 4562705 SGTC_286 k060-0067 22.9 µM 0.358865359412472 0.347220602133415 no 1174 0.359847907499388 1682 5985051 SGTC_1405 3909-7894 12 µM 0.358721491302911 0.347272124057804 no 1175 0.359901724643438 1780 7104060 SGTC_652 0437-0092 114 µM 0.357790311178698 0.34760566570663 no 1176 0.36025012090771 1649 3091274 SGTC_2486 5283202 22.39 µM 0.356011832842345 0.34824303088924 no 1177 0.360915851834217 1635 1377751 SGTC_1017 4239-0030 168 µM 0.354622081306748 0.348741384043319 no 1178 0.361436365730301 1606 1149593 SGTC_1560 lithocholic acid 53.1 µM 0.353796777898721 0.349037454495276 no 1179 0.361745594193867 1804 9903 A bile acid which acts as a detergent. SGTC_2922 7999257 32.47 µM 0.353738291370495 0.349058439520824 no 1180 0.36176751162305 1662 2988377 SGTC_371 0195-0006 7.36 µM 0.35344811507033 0.34916256189641 no 1181 0.361876259925143 1608 3928593 SGTC_2280 7785178 200 µM 0.353151947756427 0.34926884570433 no 1182 0.361987264959161 1711 2954328 SGTC_3108 9121785 49.47 µM 0.352723554455987 0.349422601583081 no 1183 0.362147849515066 1812 17140271 SGTC_2292 7671323 168.05 µM 0.351005018388728 0.350039654512681 no 1184 0.36279229175903 1679 937504 SGTC_638 3970-0837 4.09 µM 0.350958671708538 0.35005630112021 no 1185 0.362809676919635 1657 4118451 YLR208W SEC13 SGTC_2323 6148992 148.28 µM 0.350392831344049 0.350259560530716 no 1186 0.363021952791395 1669 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_755 1995-0008 37.3 µM 0.348914026760371 0.350790974525017 no 1187 0.363576927172907 1688 689533 SGTC_1863 st057641 20.1 µM 0.348758107361053 0.350847021785193 no 1188 0.363635458222034 1809 3921635 SGTC_3039 9090270 49.47 µM 0.345875892628231 0.351883654839081 no 1189 0.364717993333867 1843 17173750 SGTC_1505 k297-0037 20.6 µM 0.345354484609414 0.35207130522127 no 1190 0.364913945270579 1673 4089396 SGTC_566 0958-0068 16.5 µM 0.345244783514942 0.352110790316126 no 1191 0.364955176868073 1752 6815365 SGTC_375 3970-0961 9.27 µM 0.345023734343154 0.352190358153236 no 1192 0.365038263831399 1739 2898222 SGTC_2989 9073649 71.4286 µM 0.343499458003156 0.352739205603532 no 1193 0.365611374251523 1857 21367202 SGTC_2837 9008476 45.46 µM 0.343088435920531 0.352887255205678 no 1194 0.365765965269445 1775 2992805 SGTC_1953 st076800 12.1 µM 0.34264552774036 0.353046815074435 no 1195 0.365932573487453 1654 297591 SGTC_2344 7990960 76.95 µM 0.342361170733028 0.353149269720716 no 1196 0.366039553038928 1717 140813 SGTC_1130 3454-2858 15.9 µM 0.341645780689895 0.353407073874765 no 1197 0.366308740001974 1651 715628 YIL048W NEO1 SGTC_775 4577-0580 57.3 µM 0.341329183238995 0.353521187155754 no 1198 0.366427890300483 1753 2006902 SGTC_2355 9061122 103.12 µM 0.340804474618278 0.353710340290256 no 1199 0.366625390830135 1827 5302957 SGTC_1242 0402-0103 60.1 µM 0.340762379389091 0.353725516839381 no 1200 0.366641237021959 1698 432868 SGTC_2712 st079126 47.7 µM 0.337011082922394 0.355078898741046 no 1201 0.368054272687232 1701 3152970 SGTC_1781 st038725 66.3 µM 0.334378919972301 0.356029616787653 no 1202 0.369046822147466 1696 4270275 YIL048W NEO1 SGTC_1352 1496-0991 99 µM 0.332102503581913 0.356852564522971 no 1203 0.369905929867421 1691 3000039 SGTC_2028 5153890 36.43 µM 0.331773600440392 0.356971521567909 no 1204 0.370030110017233 1712 2830968 YPR165W RHO1 SGTC_283 0987-0079 11.7 µM 0.331684056354238 0.357003910106882 no 1205 0.370063920488165 1827 411556 SGTC_1199 1638-0010 4.46 µM 0.328187234628737 0.358269531705714 no 1206 0.371385049555719 1700 3111136 SGTC_45 0kpi-0036 14.9 µM 0.327113699441103 0.35865839487026 no 1207 0.371790945326674 1750 2795021 SGTC_936 3005-4620 401 µM 0.32341578477925 0.359998998272933 no 1208 0.373190188411798 1867 777207 SGTC_3179 9107801 49.47 µM 0.322083014859141 0.360482590261678 no 1209 0.373694902706022 1722 4818259 SGTC_3135 9127742 49.47 µM 0.321722209066703 0.36061354610734 no 1210 0.37383157563047 1713 3643468 SGTC_2054 5233173 129 µM 0.321241488702904 0.360788050806284 no 1211 0.37401369674048 1782 6889 SGTC_2868 9035608 32.47 µM 0.317872402872713 0.362011863094723 no 1212 0.375290863508224 1695 6462614 SGTC_2983 9022671 12.99 µM 0.317064969068454 0.362305371721285 no 1213 0.37559715257989 1900 6405161 SGTC_968 1309-0633 340 µM 0.314914008207171 0.363087657872528 no 1214 0.376413472672428 1873 3761976 SGTC_387 norethindrone acetate 66.7 µM 0.314455300028918 0.363254560182546 no 1215 0.37658763059242 1722 541197 SGTC_3326 9140064 16.379 µM 0.313975323072985 0.363429229000672 no 1216 0.376769890534524 1704 1868434 SGTC_407 eburnamonine 100 µM 0.3135866249523 0.363570701273594 no 1217 0.376917509620749 1726 3195 SGTC_1263 0774-1208 64.8 µM 0.312403331611253 0.364001492373484 no 1218 0.377367009364073 1901 906585 SGTC_2682 pyrogallin 40.03 µM 0.311996355894129 0.3641496961713 no 1219 0.377521646391151 1812 822798 An ATP competetive kinase inhibitor. SGTC_666 0272-0154 136 µM 0.311583318040784 0.364300128324001 no 1220 0.377678606902322 1789 6870312 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.311321288865828 0.364395572579032 no 1221 0.377778192350164 1868 77254 SGTC_3106 9121286 49.47 µM 0.308742503215543 0.365335344259734 no 1222 0.37875870467645 1851 15943471 SGTC_3339 9145883 14.936 µM 0.308694443378005 0.365352866121189 no 1223 0.378776985539336 1847 2030670 SGTC_2908 7930301 100 µM 0.308338864258317 0.365482513409641 no 1224 0.378912248126941 1711 2223178 SGTC_1131 3454-3128 32.3 µM 0.308268823658054 0.365508052643755 no 1225 0.378938893377364 1849 710982 SGTC_378 3970-0959 8.33 µM 0.307356511432296 0.365840767778463 no 1226 0.379286012981317 1813 6615653 SGTC_988 1497-1057 103 µM 0.306772946253137 0.366053643662002 no 1227 0.379508100876857 1939 3533044 SGTC_2931 9014674 55.67 µM 0.30610800768552 0.366296253607821 no 1228 0.379761205573539 1711 2996810 SGTC_1038 k292-0204 154 µM 0.304714682089227 0.366804796596772 no 1229 0.380291733199801 1722 4454212 SGTC_1957 st077035 62.4 µM 0.304047200226412 0.367048500395203 no 1230 0.380545965848961 1811 705593 SGTC_1332 1480-0653 17.5 µM 0.299557056443352 0.368689281545994 no 1231 0.382257522305648 1910 5749438 SGTC_228 caffeine 993.056 µM 0.297582090005789 0.369411731348589 no 1232 0.383011072859071 1877 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1059 3448-6867 171 µM 0.297254746423968 0.369531519445565 no 1233 0.38313601402241 1949 3934407 SGTC_2000 st075254 36.4 µM 0.297138156099759 0.369574187563514 no 1234 0.383180517391165 1771 17234175 SGTC_1489 4065-0444 182 µM 0.295744362106444 0.370084393295363 no 1235 0.383712657853977 1917 2877968 SGTC_2070 5230947 200 µM 0.29571468223892 0.370095260259363 no 1236 0.383723991801712 1892 2835538 SGTC_3325 9138760 55.175 µM 0.29511055701627 0.370316476734102 no 1237 0.383954712676054 1739 43844959 SGTC_2938 9059746 27.26 µM 0.294430902204286 0.37056540164771 no 1238 0.384214328151978 1810 6471769 SGTC_973 1325-0077 65.9 µM 0.294316049098191 0.370607472180162 no 1239 0.384258205033663 1887 2835149 SGTC_3119 9125183 49.47 µM 0.293948430503238 0.370742140758498 no 1240 0.384398654892483 1909 22695334 SGTC_1706 st031321 9.9705 µM 0.292932286497853 0.371114463977914 no 1241 0.384786954863135 1894 6103185 SGTC_533 1222-0222 6.71 µM 0.292226886744043 0.371372999024015 no 1242 0.385056577869177 1907 3982874 SGTC_1013 4112-3890 241 µM 0.291353193467931 0.371693295547068 no 1243 0.385390604290412 1759 705171 SGTC_569 4130-2812 160 µM 0.288719220198268 0.372659448688378 no 1244 0.38639812659836 1925 743552 SGTC_1948 st076329 66.6 µM 0.288540059302193 0.372725194893181 no 1245 0.386466685427343 1855 24208413 SGTC_1974 st069448 26.9 µM 0.288211162826755 0.372845898821816 no 1246 0.386592552233401 1916 6323587 YNR016C ACC1 SGTC_634 1611-4317 11.2 µM 0.284220627304485 0.37431140376779 no 1247 0.388120654361611 1950 2843522 SGTC_2196 6573537 42.6665 µM 0.281578041137237 0.375282882779039 no 1248 0.389133539902781 1919 2903087 SGTC_3118 9124250 49.47 µM 0.281241207491083 0.375406768032455 no 1249 0.389262700290921 1795 1504786 SGTC_2268 7933382 153.85 µM 0.280789099127035 0.375573070784444 no 1250 0.389436082523703 1917 935025 YOR257W CDC31 SGTC_1899 st063254 59.6 µM 0.280155465112718 0.375806184519577 no 1251 0.38967911634699 1732 3093813 SGTC_2443 5493264 126.67 µM 0.279154444281348 0.376174552095495 no 1252 0.390063151299698 1906 5340055 SGTC_712 r015-0009 80.6 µM 0.279079529213206 0.376202124777425 no 1253 0.390091896286143 1885 6813872 YLR060W FRS1 SGTC_140 0062-0056 502.533 µM 0.278797471439545 0.376305942527476 no 1254 0.39020012752528 1751 3758964 SGTC_905 2-aminofluorene 215 µM 0.278064803339249 0.376575659412981 no 1255 0.390481306756647 1793 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3002 9075603 71.4286 µM 0.278018003855081 0.37659288974194 no 1256 0.390499269146808 1880 20105405 SGTC_632 0781-2353 4.65 µM 0.277007205356525 0.376965098891441 no 1257 0.390887286744999 1864 6811515 YHR007C ERG11 SGTC_3027 9089541 49.47 µM 0.276588352079532 0.377119367935854 no 1258 0.391048104801039 1811 9943819 SGTC_1693 xanthone 101.9 µM 0.275602938994943 0.377482385557609 no 1259 0.391426526036677 1879 7020 An insecticide. SGTC_2551 apiole 73.87 µM 0.27327519687621 0.378340334958853 no 1260 0.392320839984872 1873 10659 A possible DNA adduct former. SGTC_2442 5158906 48.48 µM 0.272642032306564 0.378573808094902 no 1261 0.392564199204218 1909 1893835 SGTC_2099 5377090 177.372 µM 0.272609487957684 0.378585809698273 no 1262 0.392576708884965 1801 2243829 SGTC_214 4373-3496 70 µM 0.271508956482029 0.378991729126528 no 1263 0.392999806030712 1906 3779166 SGTC_3227 9130768 49.47 µM 0.270685168566375 0.379295661995907 no 1264 0.39331659243549 1883 17720899 SGTC_2676 harmalol 100 µM 0.270546278011281 0.379346912401462 no 1265 0.393370009554792 1910 5459187 A monoamine oxidase inhibitor SGTC_1485 3909-9022 254 µM 0.269548884535743 0.379715011325909 no 1266 0.393753664639451 1919 714516 SGTC_692 k241-0027 77.8 µM 0.269430489580682 0.379758713519084 no 1267 0.393799213027423 1921 3600480 SGTC_3349 9149703 23.001 µM 0.26905044035253 0.37989900845938 no 1268 0.393945433715018 1839 4910494 SGTC_1173 0443-0020 122 µM 0.268129679606237 0.380238972236278 no 1269 0.39429975048744 1802 5331295 SGTC_2828 7998861 71.43 µM 0.267434345870776 0.380495765075744 no 1270 0.394567378972804 1967 2988188 SGTC_37 0566-0070 1.56 µM 0.266785622313167 0.380735391863022 no 1271 0.394817112448853 1924 1626686 SGTC_3336 9143619 71.43 µM 0.266676512654906 0.380775699501563 no 1272 0.394859119695842 1943 45595730 SGTC_651 3253-0966 34.4 µM 0.265905077742661 0.38106072234647 no 1273 0.395156157183823 1838 781462 SGTC_2787 5284540 71.43 µM 0.261506521874812 0.382687090099403 no 1274 0.396850960366185 1816 736958 SGTC_1802 st050112 57.9 µM 0.259146981122096 0.383560386556658 no 1275 0.397760918438931 1926 4662563 SGTC_877 0771-0151 33.1 µM 0.258843190925836 0.383672866323299 no 1276 0.397878115822826 1868 6166523 SGTC_1813 st051246 8.6015 µM 0.257718050251976 0.38408954033233 no 1277 0.398312257240558 1964 5291959 SGTC_2069 5228469 200 µM 0.255998134720387 0.384726736515621 no 1278 0.398976138807743 1843 2835210 SGTC_3132 9126706 49.47 µM 0.254726395036621 0.385198092452476 no 1279 0.399467214135216 1884 850858 SGTC_2692 st077426 47.7 µM 0.25459327917829 0.385247440161288 no 1280 0.399518625307789 1956 25238571 SGTC_3077 9117319 49.47 µM 0.252571512254388 0.385997162371891 no 1281 0.400299673157019 1917 17154678 SGTC_2945 9067681 61.76 µM 0.252481749086182 0.38603045871699 no 1282 0.400334359684497 1899 16456930 SGTC_1217 1183-1422 255 µM 0.251925537208949 0.386236796153465 no 1283 0.40054931010769 1940 2849664 SGTC_3317 9138495 8.753 µM 0.251734998097404 0.386307487684689 no 1284 0.400622951679965 1874 17020139 SGTC_2077 5212015 200 µM 0.250755321455004 0.386671015078663 no 1285 0.401001643193298 1914 780900 SGTC_997 3996-0078 137 µM 0.250743032994371 0.386675575574782 no 1286 0.40100639385804 1867 735687 SGTC_1915 st067105 30.6 µM 0.250250989480913 0.386858195720522 no 1287 0.401196627732914 1865 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1610 st001799 48.1 µM 0.249785298858367 0.387031058164392 no 1288 0.401376694630599 1796 621897 SGTC_3302 9125395 16.351 µM 0.248668915578862 0.387445546236203 no 1289 0.401808447717611 1861 17599668 SGTC_1210 3013-0140 750 nM 0.246996663203796 0.388066655993086 no 1290 0.402455403232367 1994 905973 SGTC_462 ag-879 158 µM 0.245719886976678 0.388541070506669 no 1291 0.402949538257739 1968 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1694 st024011 44.9 µM 0.245512633407195 0.388618095872979 no 1292 0.403029763708719 1914 2787533 SGTC_182 3448-4371 550.524 µM 0.241864070455273 0.389974791447365 no 1293 0.404442745641084 2067 3491403 SGTC_3301 9125354 19.7965 µM 0.240710111484602 0.39040416396789 no 1294 0.404889900769047 1838 41905162 SGTC_88 0180-0332 8.668 µM 0.240481570160433 0.390489216981358 no 1295 0.404978474500523 1887 3101745 SGTC_3152 9099253 49.47 µM 0.239159183364652 0.390981453867537 no 1296 0.405491075648263 1943 25236131 SGTC_1055 3448-0672 86 µM 0.23823344499525 0.391326148866432 no 1297 0.405850019194823 1911 748378 SGTC_481 bay k-8644 50 µM 0.236992494552248 0.391788345697219 no 1298 0.406331306449942 1844 2303 A calcium channel antagonist. SGTC_1786 berberine 21.6 µM 0.236840633639764 0.391844917390757 no 1299 0.406390213559516 1831 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1728 st035614 33.7865 µM 0.23640048930096 0.392008894226741 no 1300 0.40656095827173 1878 15945546 SGTC_2295 7971645 200 µM 0.235917909414278 0.392188702573415 no 1301 0.406748185377481 1935 2978226 YKL099C UTP11 SGTC_1204 4049-0315 18.3 µM 0.234941396493086 0.392552619820578 no 1302 0.407127109450852 1983 588402 SGTC_3180 9109287 49.47 µM 0.234331102598999 0.392780105892449 no 1303 0.407363970813455 1904 18891271 SGTC_2872 9044037 25.97 µM 0.23313823169672 0.393224852313544 no 1304 0.407827034069555 1956 6465195 SGTC_2170 morpholine 200 µM 0.232747355514527 0.393370615768748 no 1305 0.407978797226629 1976 121171 Reacts with secondary amines. SGTC_1981 st071826 47 µM 0.231703746635991 0.393759865987087 no 1306 0.408384060588262 1889 11838600 SGTC_3003 9075612 71.4286 µM 0.231406747306666 0.393870661639046 no 1307 0.408499411908235 1899 6501993 SGTC_1186 1319-0216 26 µM 0.229537478612453 0.394568189505606 no 1308 0.409225597190691 2049 4565136 SGTC_2731 amoxapine 43.43 µM 0.229388194634823 0.394623910251885 no 1309 0.409283605441247 2020 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_221 trifluoperazine 10.304 µM 0.229027609889745 0.394758508610396 no 1310 0.409423728403093 1915 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_914 3820-6779 408 µM 0.228183588618109 0.395073612288756 no 1311 0.409751759652457 1888 2893481 SGTC_1351 1496-0003 46.5 µM 0.227052403423465 0.39549603225017 no 1312 0.410191497015736 1984 3891978 SGTC_768 0384-0033 77.3 µM 0.226816437205744 0.395584164919432 no 1313 0.410283240869759 1834 3965305 YMR134W ERG29 SGTC_1190 1486-1332 13 µM 0.225400572454976 0.396113098120353 no 1314 0.410833833173277 1963 4150046 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.223240232014646 0.39692051798635 no 1315 0.411674270648592 2036 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_750 4073-0104 132 µM 0.222357571681212 0.397250536682029 no 1316 0.412017768966202 1991 22330957 SGTC_828 2074-0507 139 µM 0.22211745516602 0.397340326810117 no 1317 0.412111224990176 2004 X828 SGTC_2900 5328528 85.29 µM 0.221235876024782 0.39767003465467 no 1318 0.412454388123674 1914 795359 SGTC_490 phenamil 164 µM 0.221169921010507 0.397694704566316 no 1319 0.412480064439742 2015 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1838 st055369 84.5 µM 0.220241750218729 0.398041922298623 no 1320 0.412841441412165 2009 676036 SGTC_724 3910-0327 137 µM 0.219779757931166 0.398214778278758 no 1321 0.413021342518333 1876 2885483 SGTC_1564 D-Arginine 115 µM 0.219617315641581 0.398275561360578 no 1322 0.413084602348924 1817 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1569 carminic acid 40.6 µM 0.21857484413282 0.398665694771807 no 1323 0.413490625224237 2031 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2428 5615643 7.78 µM 0.218049269812822 0.398862423565426 no 1324 0.413695361560398 1966 2253075 SGTC_885 0865-0106 16.8 µM 0.21675627963616 0.399346514624083 no 1325 0.414199142836869 1849 2793380 SGTC_3194 9111903 49.47 µM 0.216655633059051 0.399384202858733 no 1326 0.414238363191949 1969 17087251 SGTC_1678 st019265 80.2 µM 0.216520323009665 0.399434872695328 no 1327 0.41429109269332 2065 5367020 SGTC_1596 piperlongumine 63 µM 0.216354488357232 0.399496975454008 no 1328 0.414355719553245 2042 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_61 0978-8327 98.565 µM 0.216320211090275 0.399509812128418 no 1329 0.41436907791992 2065 6150059 YHR072W ERG7 SGTC_2051 5263410 176 µM 0.214628815403102 0.4001433664853 no 1330 0.415028363001164 2049 227584 SGTC_1989 st071868 50.2 µM 0.214576094363806 0.400163118696439 no 1331 0.415048916865388 2035 16414057 SGTC_3263 9137018 49.47 µM 0.213194123635687 0.400680972150775 no 1332 0.415587775786222 1832 43844957 SGTC_1836 st055642 81 µM 0.212291910555211 0.401019144602448 no 1333 0.415939653025263 1840 8571 SGTC_2992 9074591 71.4286 µM 0.210967598998587 0.401515664604213 no 1334 0.416456277287054 2037 17741321 SGTC_402 epigallocatechin gallate 10 µM 0.210564343339028 0.401666887617033 no 1335 0.416613619174499 1898 65064 An antioxidant. SGTC_1688 st021091 57.6 µM 0.210182212788592 0.401810202191523 no 1336 0.416762730817641 2057 3656366 SGTC_1667 st014849 34.6 µM 0.209866448083982 0.401928636826604 no 1337 0.416885954798711 1991 5348460 SGTC_2269 7935389 174.42 µM 0.208683613017935 0.402372365622551 no 1338 0.417347616708423 1855 97605 SGTC_486 niguldipine 82 µM 0.208294134098566 0.402518502325387 no 1339 0.41749965575863 1978 1236 A calcium channel blocker. SGTC_1447 4239-0816 81.9 µM 0.207864781128873 0.402679615989197 no 1340 0.417667274546784 1869 1341554 SGTC_3046 9092212 49.47 µM 0.206393868361857 0.403231697601477 no 1341 0.418241630033205 1981 25236637 SGTC_1441 4106-0040 13 µM 0.20626536511597 0.403279938247164 no 1342 0.418291815710574 2029 2904180 SGTC_675 1309-0189 238 µM 0.205653448633042 0.403509674385634 no 1343 0.418530811903019 1920 4246530 SGTC_1762 st045503 25.4615 µM 0.204869304112608 0.403804119983157 no 1344 0.418837119147942 1896 4645554 SGTC_74 000s-0487 160.283 µM 0.204621896416136 0.403897032684567 no 1345 0.41893377325055 2086 677548 SGTC_3246 9135460 32.98 µM 0.201857146133307 0.404935688304735 no 1346 0.420014202404769 2007 41446951 SGTC_184 1494-0393 24.714 µM 0.200792634023185 0.405335781063684 no 1347 0.420430361416276 1882 3090647 SGTC_323 4013-0906 34.3 µM 0.199581285365634 0.405791182107392 no 1348 0.42090403271077 2067 2910086 SGTC_3287 9117173 37.0625 µM 0.199457084469247 0.40583788209046 no 1349 0.420952605228898 2083 2789709 SGTC_2241 6772625 37.8075 µM 0.199442178890489 0.405843486731675 no 1350 0.420958434587312 2099 2285411 SGTC_2760 etidronate 98.04 µM 0.199305288938906 0.405894959574652 no 1351 0.421011971097419 1938 3305 A chelator and antioxidant. SGTC_2202 7226349 200 µM 0.198596399303662 0.406161539588045 no 1352 0.421289235224532 1953 844334 SGTC_986 1493-0483 84 µM 0.198049963616588 0.406367058023181 no 1353 0.421502986277059 2068 40079 SGTC_3036 9090181 49.47 µM 0.195043292686215 0.407498348872627 no 1354 0.422679527867613 1955 25236586 SGTC_1150 3909-7983 10.9 µM 0.193148146069578 0.408211814499197 no 1355 0.423421473696361 1933 23965914 SGTC_2794 7785382 27.27 µM 0.19313171520419 0.408218001559616 no 1356 0.423427907536308 2112 2205081 SGTC_2472 5377652 49.4 µM 0.192945476055717 0.40828813171487 no 1357 0.423500834694356 1925 1610903 SGTC_1979 st071809 45.3 µM 0.192110593637744 0.408602550846731 no 1358 0.4238277884742 2038 4976333 SGTC_570 0987-0065 62.6 µM 0.191865085622873 0.408695021078761 no 1359 0.423923943466524 2081 3104428 SGTC_1266 0828-0227 32.9 µM 0.190555341626966 0.409188419995307 no 1360 0.424436990589785 1990 3913820 SGTC_2417 cerulenin 830 nM 0.190431024406644 0.409235259524216 no 1361 0.424485694249095 2106 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_31 0508-1974 57.237 µM 0.189981570087219 0.409404613150865 no 1362 0.424661786227723 2030 6810525 SGTC_1271 0832-2808 169 µM 0.189033184673426 0.409762018612586 no 1363 0.425033404018481 2084 3663794 SGTC_1232 0279-0259 161 µM 0.188504931623847 0.409961126888356 no 1364 0.425240424970658 1910 1560000 SGTC_2516 gossypol 71.55 µM 0.188349949099017 0.410019547055676 no 1365 0.425301166120088 2052 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_840 0245-0196 390 µM 0.188080985235881 0.410120936864166 no 1366 0.425406583336427 2064 3827528 SGTC_1575 cyproterone acetate 48 µM 0.187532135176274 0.410327852446704 no 1367 0.425621715185441 1920 9880 An androgen receptor antagonist and liver toxin. SGTC_2118 5526350 200 µM 0.186153121297097 0.41084784848632 no 1368 0.426162342548619 1997 743594 SGTC_390 dec-rvkr-cmk 16.7 µM 0.185973749920645 0.410915497055271 no 1369 0.426232673364416 1997 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2140 5586273 200 µM 0.185335368575965 0.411156279272438 no 1370 0.426482999213729 2068 854421 SGTC_3112 9123419 49.47 µM 0.184888660318261 0.411324786884949 no 1371 0.426658182704627 2122 17015854 SGTC_2993 9054257 71.4286 µM 0.184777114916592 0.41136686667604 no 1372 0.426701929202719 2029 6470217 YGL055W OLE1 SGTC_250 brefeldin a 552.239 µM 0.184501940542161 0.411470678812509 no 1373 0.426809852479199 1988 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1811 st050069 61.5 µM 0.183120642643297 0.411991880020803 no 1374 0.427351679573912 2123 3877702 SGTC_2957 9076800 11.52 µM 0.182311083618454 0.412297420861882 no 1375 0.427669300489625 1939 16459615 SGTC_193 1273-0060 1.558 µM 0.182000691874668 0.412414581901065 no 1376 0.427791091466193 2086 2847393 YHR072W ERG7 SGTC_2279 7948423 32.93 µM 0.181386042733169 0.412646611519389 no 1377 0.428032286726718 2107 1247112 SGTC_3044 9093193 49.47 µM 0.179183758243704 0.413478222458489 no 1378 0.428896708189044 1925 25236277 SGTC_2031 5180455 200 µM 0.17881940323335 0.413615845127729 no 1379 0.42903975463494 2039 29949 SGTC_2407 paclitaxel 400 µM 0.177359451429665 0.414167398381677 no 1380 0.429613027702974 2008 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_538 2922-0838 53.3 µM 0.177210697729446 0.414223605367948 no 1381 0.429671446539823 2101 777039 SGTC_998 3996-0085 177 µM 0.177200496626321 0.414227459946621 no 1382 0.429675452792936 2067 715391 SGTC_783 0848-0141 92.7 µM 0.176792472898544 0.414381642156316 no 1383 0.429835700840381 2007 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1007 4101-0031 70 µM 0.176775818860756 0.414387935591204 no 1384 0.429842241825909 2089 1146276 SGTC_1433 4060-0023 7.6 µM 0.174755093691034 0.415151715009679 no 1385 0.430636037646276 2057 3840627 SGTC_2523 spermine 47.74 µM 0.174469218517658 0.415259794054006 no 1386 0.430748359901628 2097 1103 A DNA binding polyamine. SGTC_1189 1431-2119 7.28 µM 0.173931561562636 0.415463080031714 no 1387 0.430959624061695 2062 3107275 SGTC_2473 5854593 8.94 µM 0.172887139731994 0.415858036442029 no 1388 0.431370070220576 1956 2872951 SGTC_2635 hydroquinidine 100 µM 0.172510984427662 0.41600030339896 no 1389 0.431517913247144 1992 442912 An experimental heart treatment. SGTC_935 2996-0153 430 µM 0.172082672188492 0.416162310207471 no 1390 0.431686267569691 2112 23738523 SGTC_2799 7812892 81.82 µM 0.171546143806411 0.416365269288494 no 1391 0.431897175317295 2079 20205235 SGTC_248 streptozotocin 5.23457 mM 0.170284120867542 0.416842757802655 no 1392 0.432393349296961 2123 5300 DNA alkylating agent. SGTC_109 0132-0036 33.701 µM 0.169134399970163 0.417277863482171 no 1393 0.43284546371757 2124 67274 A color developer. SGTC_699 0375-0592 111 µM 0.168859307032773 0.417381985964004 no 1394 0.432953653885211 2168 762578 SGTC_158 k038-0087 26.446 µM 0.168804739170249 0.417402640550128 no 1395 0.432975115252567 2005 X158 SGTC_389 tpck 16.7 µM 0.168415974257694 0.417549799294254 no 1396 0.433128020977949 1987 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2195 6536160 144.242 µM 0.168115383827726 0.417663589368341 no 1397 0.433246253526338 1976 3834386 SGTC_2308 7584454 197.62 µM 0.168063114983386 0.417683376715753 no 1398 0.433266813269571 2083 893577 SGTC_3052 9092717 49.47 µM 0.168050060855093 0.417688318632399 no 1399 0.433271948087503 1999 25237534 SGTC_2733 amorolfine 100 µM 0.166957177682998 0.418102098722108 no 1400 0.433701871585952 2151 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_126 0417-1624 672.48 µM 0.165567486194847 0.418628385273335 no 1401 0.434248668169945 2138 41912 YDL195W SEC31 SGTC_2152 5568786 200 µM 0.162443565938187 0.419811967668698 no 1402 0.4354782828726 2077 5399883 SGTC_308 4092-1169 104 µM 0.16104310823333 0.420342805504662 no 1403 0.436029724135014 2046 2268590 YDL196W YDL196W SGTC_952 1185-0122 232 µM 0.160771595606952 0.42044573807024 no 1404 0.436136648799915 2081 678600 SGTC_212 3807-4682 38.772 µM 0.159893348409051 0.420778725694632 no 1405 0.436482544154282 2096 3125501 YBL034C STU1 SGTC_2190 6049624 200 µM 0.15964462434567 0.420873039790814 no 1406 0.436580512311798 2093 2265554 SGTC_262 fenpropimorph 62.5 µM 0.159145618962778 0.42106227217252 no 1407 0.436777073728828 2113 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1334 1486-0610 236 µM 0.157450771757616 0.421705126550208 no 1408 0.437444801165999 2072 3742339 SGTC_746 1095-0025 46.6 µM 0.157297890797177 0.421763124480992 no 1409 0.437505041233739 2098 6749286 SGTC_1668 st014914 51.6 µM 0.155631783715199 0.422395299631253 no 1410 0.438161635207364 2105 2839556 SGTC_2126 5251174 33.877 µM 0.154318698793265 0.422893667689641 no 1411 0.438679227205739 2137 790722 SGTC_1581 himbacine 57.9 µM 0.153148266899144 0.423337997307542 no 1412 0.439140676658196 1982 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2560 caryophyllene 100 µM 0.152570928780498 0.423557207415528 no 1413 0.439368326009894 2158 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_316 k060-0003 58.6 µM 0.150903271834935 0.424190534457568 no 1414 0.44002600974722 2119 6152314 SGTC_1651 st011928 86.1 µM 0.150763591066083 0.424243590013973 no 1415 0.440081104016252 2090 720198 SGTC_3231 9132313 49.47 µM 0.149339564668877 0.424784562358609 no 1416 0.440642848603419 2056 4905967 SGTC_1066 ketoconazole 628 nM 0.14914497396552 0.424858496304799 no 1417 0.440719619316958 2108 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2185 6113692 200 µM 0.149087644308872 0.424880278978857 no 1418 0.440742237670666 2033 874150 SGTC_1030 k029-0042 36.7 µM 0.146978762111242 0.425681717608177 no 1419 0.441574391814641 2015 6080581 SGTC_3342 9147791 14.508 µM 0.146663772419449 0.425801449602696 no 1420 0.441698707369994 2118 1838168 SGTC_2984 9022109 38.96 µM 0.146075661633655 0.426025017054163 no 1421 0.441930829753346 2188 6459207 SGTC_2696 st077691 74.316 µM 0.14579914657106 0.426130141131513 no 1422 0.44203997482131 2068 757133 SGTC_1249 0481-0015 10.2 µM 0.144790785824741 0.426513538965638 no 1423 0.442438028703928 2051 4227577 SGTC_152 4469-0003 551.229 µM 0.144391063294643 0.42666554027713 no 1424 0.442595836659739 2184 697280 SGTC_816 0325-0417 81.3 µM 0.143661407821195 0.426943032290978 no 1425 0.442883923549549 2029 68101 SGTC_1481 3346-2004 36 µM 0.143640516536165 0.426950977895374 no 1426 0.442892172415704 2162 2770522 SGTC_1425 4048-4433 7.33 µM 0.143096299394743 0.427157971006086 no 1427 0.443107063760802 2136 23734946 SGTC_50 0929-0078 56.389 µM 0.138706589777534 0.428828326609113 no 1428 0.44484100527642 2102 1377751 SGTC_1317 1273-0028 910 nM 0.137382567946586 0.429332390112713 no 1429 0.445364204579056 2065 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_698 k064-0052 127 µM 0.13705914586972 0.429455536493098 no 1430 0.445492022261217 2165 5088751 SGTC_836 0330-0104 1.35 µM 0.135834107098896 0.429922045127191 no 1431 0.445976213687135 2176 46494820 SGTC_838 0109-0203 71.4 µM 0.135170098733275 0.430174947967554 no 1432 0.446238693922943 2155 759422 SGTC_2786 7743617 45.45 µM 0.132537884118754 0.431177768266062 no 1433 0.447279430061583 2020 583674 SGTC_2356 9061756 188.97 µM 0.131698488386906 0.431497654632132 no 1434 0.447611390598287 2163 20104043 SGTC_2981 9013952 38.96 µM 0.131371610894036 0.431622236950401 no 1435 0.447740672614317 1931 2996344 SGTC_1446 4239-0190 62 µM 0.130626947481115 0.43190607475444 no 1436 0.448035212185104 2001 1340085 SGTC_557 1315-0110 16.2 µM 0.129101142330592 0.432487764191607 no 1437 0.448638809062524 2163 6833801 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.128799733053195 0.43260268913261 no 1438 0.448758058381888 2175 88881 An O-methylated flavonoid and antioxidant. SGTC_352 k048-0007 5.11 µM 0.128283156038584 0.432799669061669 no 1439 0.448962447248958 2169 6811911 SGTC_466 geldanamycin 89.2 µM 0.127980433446345 0.432915110290614 no 1440 0.449082228770985 2185 5288382 HSP90 inhibitor. SGTC_1393 3470-5649 58.2 µM 0.127749507110239 0.433003176349255 no 1441 0.449173605012742 2092 4108395 SGTC_2666 tannic acid 100 µM 0.127244848760803 0.43319564441343 no 1442 0.449373304836066 2159 16134267 A thiamine antagonist. SGTC_509 pifithrin 175 µM 0.127231822351656 0.433200612673098 no 1443 0.449378459724317 2192 4817 A p53 inhibitor. SGTC_287 k060-0039 29.6 µM 0.126950908873199 0.43330775536552 no 1444 0.449489626557216 2187 5861974 SGTC_199 4063-0024 41.6 µM 0.12670984896037 0.433399701491241 no 1445 0.449585025166007 2161 306215 SGTC_2151 5563267 85.4165 µM 0.126609195927501 0.433438094078129 no 1446 0.44962485911082 2055 5310824 SGTC_142 0335-0849 62.6745 µM 0.126147004384221 0.433614398155843 no 1447 0.449807780253735 2162 3889043 YPR107C YTH1 SGTC_2563 tomatine 8.54 µM 0.125439546935116 0.433884285077197 no 1448 0.450087790713079 2264 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1675 st018485 24.5 µM 0.124970044172396 0.434063412033513 no 1449 0.450273632837595 2044 3323024 SGTC_3122 9126309 49.47 µM 0.12465969663346 0.434181824757694 no 1450 0.450396482929831 2211 17591206 SGTC_279 1273-0055 2.93 µM 0.124444811695532 0.434263817304145 no 1451 0.450481547238698 2184 2847562 SGTC_1924 st058459 75.1 µM 0.123512883231491 0.434619441163367 no 1452 0.450850486530733 2205 688683 SGTC_2528 xanthyletin 44.79 µM 0.123468138002787 0.434636517273974 no 1453 0.450868201700677 2080 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2947 9072639 7.68 µM 0.122840844412123 0.434875923995545 no 1454 0.451116565005753 2091 16488146 SGTC_416 estradiol valerate 100 µM 0.120577763636418 0.435739827066172 no 1455 0.452012741181436 2084 13791 A steroid. SGTC_1409 3909-8004 61.9 µM 0.119799376155841 0.436037037953039 no 1456 0.452321038070108 2098 2119279 SGTC_202 3594-0513 34.79 µM 0.119681739283844 0.436081958264516 no 1457 0.452367633156314 2208 708429 SGTC_419 nsc-638432 893 µM 0.118987397592442 0.436347113381709 no 1458 0.452642670055479 2084 368090 SGTC_194 1486-1323 56.904 µM 0.118745738839291 0.436439404712586 no 1459 0.452738399263316 2061 5178754 SGTC_2006 4011487 200 µM 0.117430740118136 0.436941673324977 no 1460 0.453259362747679 2170 45595294 SGTC_983 1491-0821 12.2 µM 0.117371572584998 0.436964274978578 no 1461 0.453282805067203 2196 46495113 SGTC_1608 st001473 40.5 µM 0.117093244487724 0.437070597452419 no 1462 0.453393081514311 2021 7292267 SGTC_2861 9024595 19.48 µM 0.117055150796814 0.437085149752258 no 1463 0.453408174905198 2212 16482810 SGTC_1708 st033234 31.827 µM 0.112243683870648 0.438923872404441 no 1464 0.455315096635312 2177 674664 SGTC_338 4055-0136 114 µM 0.110759913897178 0.439491169349276 no 1465 0.455903366889304 2188 2900563 SGTC_90 0870-0863 4.608 µM 0.110527090156803 0.439580197285621 no 1466 0.45599568332192 2176 1738164 SGTC_3032 9089427 49.47 µM 0.10831497022858 0.440426227069408 no 1467 0.456872923977701 2118 17173707 SGTC_2321 7390090 138.78 µM 0.107197505303112 0.440853707475625 no 1468 0.457316147253375 2076 649046 SGTC_2150 5556613 200 µM 0.106937509880832 0.440953177277472 no 1469 0.457419277607559 2138 743190 SGTC_3073 9114972 49.47 µM 0.106031410532631 0.441299864465567 no 1470 0.457778715326546 2241 41905075 SGTC_2493 resveratrol 26.09 µM 0.105517447359633 0.441496534488797 no 1471 0.457982613140433 2197 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_522 1273-0010 11.6 µM 0.10501878144264 0.44168736474561 no 1472 0.458180452846025 2137 5705015 SGTC_3099 9120367 49.47 µM 0.104479422065418 0.441893782876566 no 1473 0.458394448854845 2222 24824940 SGTC_2023 5144124 124 µM 0.103983545558217 0.442083573610688 no 1474 0.458591203259451 2146 2830192 SGTC_1378 2093-0007 380 nM 0.102413555819448 0.442684555670623 no 1475 0.459214212130082 2129 3618014 SGTC_2281 7943571 200 µM 0.101604344549641 0.442994368187803 no 1476 0.459535365423628 2260 1244024 SGTC_2017 5132927 60.65 µM 0.101170499446415 0.443160483358686 no 1477 0.459707557283541 2166 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3120 9124077 49.47 µM 0.100965520685601 0.443238971257002 no 1478 0.459788915388686 2248 18774327 YGL155W CDC43 SGTC_112 phenothiazine 287.218 µM 0.0990224358889984 0.443983103131319 no 1479 0.460560228192984 2235 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_78 0336-0123 156.75 µM 0.0985044910609069 0.44418149090029 no 1480 0.460765852977172 2025 6765896 SGTC_413 propylparaben 100 µM 0.097890480106251 0.444416692874203 no 1481 0.461009629727209 2105 7175 A pharmaceutical preservative. SGTC_1648 st011736 69.8 µM 0.0958885375993208 0.445183689034733 no 1482 0.461804549150014 2213 2855514 SGTC_2899 9053889 58.44 µM 0.095061990719507 0.445500420635939 no 1483 0.462132794160295 2259 6470052 SGTC_2219 9098279 200 µM 0.0945064882771379 0.445713307949555 no 1484 0.462353414307947 2243 902349 SGTC_2224 6650123 117.647 µM 0.094003467246484 0.445906096118432 no 1485 0.462553201235337 2213 2908370 SGTC_1323 1348-1351 11.2 µM 0.0931389354557196 0.446237466993228 no 1486 0.462896592918508 2107 6989654 SGTC_1934 st074720 32.6 µM 0.0912691828484585 0.446954262294878 no 1487 0.463639352142984 2229 17250992 SGTC_2763 lisinopril 49.32 µM 0.0904315105325528 0.447275451824147 no 1488 0.463972158742132 2263 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2512 diallyl trisulfide 49.23 µM 0.0889694865768981 0.447836119850025 no 1489 0.46455308005542 2258 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_366 0181-0206 4.31 µM 0.0889200748957702 0.447855070443139 no 1490 0.464572714644032 2248 274874 SGTC_1901 st060216 58.6 µM 0.0886558861037564 0.447956395350868 no 1491 0.464677696105802 2251 688792 SGTC_3318 9139014 38.6185 µM 0.088625955163897 0.447967875044259 no 1492 0.46468959000485 2187 16643984 SGTC_235 0330-0087 5 mM 0.0881311156677237 0.448157671774504 no 1493 0.464886232932434 2218 46494818 YHR062C RPP1 SGTC_2520 obtusaquinone 4.71 µM 0.0881112983139336 0.448165273009712 no 1494 0.464894108275921 2235 5967872 SGTC_835 0312-0010 67.2 µM 0.0879657236988887 0.448221110860661 no 1495 0.464951959513688 2228 1626196 SGTC_1272 0839-0021 27 µM 0.0878012831107085 0.448284186340346 no 1496 0.465017308965365 2186 5027250 SGTC_1999 st074831 12.5 µM 0.0873776736010875 0.448446678842865 no 1497 0.46518565768901 2105 17112523 SGTC_945 3381-0768 11.3 µM 0.0870152425724763 0.448585710739879 no 1498 0.465329698121379 2250 1126236 YIL048W NEO1 SGTC_1747 st037496 66.6 µM 0.0868046050395784 0.448666516149517 no 1499 0.465413413575729 2202 723305 SGTC_2107 5363541 170.161 µM 0.0866779197383308 0.448715116575037 no 1500 0.465463763922743 2257 244052 SGTC_1500 4488-1866 171 µM 0.0866643206020264 0.448720333672845 no 1501 0.465469168854413 2242 2900003 SGTC_2784 7567673 72.73 µM 0.0861113586982192 0.44893247643508 no 1502 0.465688947115481 2258 3471247 SGTC_2792 7535235 81.82 µM 0.0846285396631666 0.449501428990801 no 1503 0.466278354541887 2149 1281891 SGTC_3043 9092303 49.47 µM 0.0845480000118889 0.449532334761138 no 1504 0.466310370469102 2196 25236084 SGTC_1992 st073643 23.3 µM 0.0831510977199649 0.450068421649412 no 1505 0.466865698190283 2267 3161292 SGTC_1515 3460-0031 42.1 µM 0.0818560752491891 0.450565491709929 no 1506 0.4673805820203 2211 2876596 SGTC_1594 piperine 70.1 µM 0.0787380112339165 0.451762618696135 no 1507 0.468620505363908 2263 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2771 fluoxetine 41.05 µM 0.0781037212802296 0.452006197461109 no 1508 0.468872773542923 2226 3386 A selective serotonin reuptake inhibitor. SGTC_1238 0333-0287 48.8 µM 0.0776458019477332 0.45218205796644 no 1509 0.469054903823355 2226 7226 SGTC_1126 isoteolin 1.0172 µM 0.0774361846722156 0.452262563050652 no 1510 0.469138277991971 2267 133323 SGTC_1074 carmofur 3.8 µM 0.0767556523073545 0.452523940113777 no 1511 0.469408965470232 2276 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3204 9114183 49.47 µM 0.0760325496302729 0.452801690012766 no 1512 0.469696601139837 2224 17027248 SGTC_1388 3346-4487 254 µM 0.075426856745631 0.453034359590446 no 1513 0.469937545738069 2211 3345614 SGTC_2893 9048488 25.97 µM 0.0751264965686477 0.453149745296356 no 1514 0.470057033089321 2181 6467338 SGTC_372 0155-0182 15.9 µM 0.074791890457722 0.453278291502513 no 1515 0.470190147111901 2190 771486 SGTC_2331 7980721 200 µM 0.071625310879436 0.45449504236892 no 1516 0.471450048317449 2232 2981221 SGTC_880 0833-0487 87.2 µM 0.0713760057003107 0.454590855592538 no 1517 0.4715492527858 2286 76075 SGTC_1022 4477-0945 21.3 µM 0.0709470518562508 0.454755717757231 no 1518 0.471719947864814 2259 4648966 SGTC_2805 7950783 58.44 µM 0.0703356832956984 0.454990701825405 no 1519 0.471963240830183 2221 1178958 YDL195W SEC31 SGTC_408 cantharidin 100 µM 0.0674315488625904 0.456107141280568 no 1520 0.473119076988965 2193 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3143 9086658 49.47 µM 0.0663159612780835 0.456536100424801 no 1521 0.473563137967623 2160 25236626 SGTC_2272 7805186 180 µM 0.0650422057717258 0.457025939274444 no 1522 0.474070198016387 2303 2956062 YPR165W RHO1 SGTC_2129 girgensonine 121.053 µM 0.0642538053810797 0.457329161418168 no 1523 0.474384067684319 2241 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_203 k066-0004 30.888 µM 0.0628149462187449 0.457882616689051 no 1524 0.474956932005911 2305 6795412 SGTC_962 1254-0300 21.5 µM 0.0614126522606388 0.458422085802826 no 1525 0.475515288166455 2259 7340576 SGTC_2240 6690706 185.951 µM 0.0611186060583809 0.458535216513986 no 1526 0.475632375679515 2270 805876 SGTC_353 1988-1175 58.3 µM 0.0604791786293181 0.45878124004551 no 1527 0.475886999267993 2239 2788357 SGTC_1530 rhein 70.4 µM 0.0600663201511375 0.458940098211016 no 1528 0.476051407067533 2289 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_322 k048-0136 19.3 µM 0.0576608479636853 0.459865796537067 no 1529 0.477009390290042 2257 6823282 SGTC_2437 5741531 144.16 µM 0.0569957560551954 0.460121782597919 no 1530 0.477274287912417 2291 2262990 SGTC_2748 diazoxide 86.69 µM 0.0568152262192948 0.460191269267376 no 1531 0.477346192380653 2280 3019 A potassium channel activatior. SGTC_2966 9084041 48.03 µM 0.0553554173802196 0.460753200119477 no 1532 0.477927656560572 2295 17741380 SGTC_1341 1486-1360 280 µM 0.054359004665143 0.461136798872613 no 1533 0.47832457003686 2303 3976547 SGTC_1692 fluoroquinolonic acid 71 µM 0.053691668823065 0.461393729924229 no 1534 0.478590410272474 2257 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_332 4112-0506 40.9 µM 0.053579508993406 0.461436914178228 no 1535 0.478635091255821 2297 2790355 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0530874953715931 0.461626356718137 no 1536 0.478831097325839 2257 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3248 9135562 49.47 µM 0.05303578629232 0.461646267037733 no 1537 0.478851697243494 2305 17650701 SGTC_3236 9132701 49.47 µM 0.0528896937768353 0.461702519741618 no 1538 0.478909898039326 2239 24282524 SGTC_1160 4092-0570 10.5 µM 0.0528722039725532 0.461709254215888 no 1539 0.478916865712733 2284 4994975 SGTC_2388 9080168 200 µM 0.0528434017179303 0.461720344589343 no 1540 0.478928340109241 2322 15943073 SGTC_1933 st074711 15.9 µM 0.0523821205742731 0.461897965989588 no 1541 0.479112110135728 2307 17250958 SGTC_1539 benzyladenosine 56 µM 0.0506825302907249 0.462552477316049 no 1542 0.479789248782518 2311 92208 A nucleotide analog. SGTC_721 1187-1332 279 µM 0.050221957807334 0.462729861074895 no 1543 0.47997275691557 2299 25730 SGTC_2865 9030313 51.95 µM 0.049756860624868 0.462908994986477 no 1544 0.480158072153841 2303 42562754 SGTC_561 1550-0330 72.9 µM 0.0497361301788027 0.462916979570343 no 1545 0.480166332178344 2272 6812934 SGTC_1871 st057448 67.3 µM 0.048868558672416 0.463251148663181 no 1546 0.480512022728603 2307 691747 SGTC_1196 1588-0294 184 µM 0.0485010197711145 0.463392724241399 no 1547 0.480658475870061 2233 6144269 SGTC_521 r062-0005 13.8 µM 0.0482843413731468 0.463476190694134 no 1548 0.480744816885958 2310 2832033 SGTC_1421 4029-0249 71.4 µM 0.0476918132673586 0.46370444600769 no 1549 0.480980929373178 2327 2894095 SGTC_2764 methyldopa 94.69 µM 0.0474938994662994 0.463780689574438 no 1550 0.48105979618575 2323 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_707 0865-0008 204 µM 0.0474325585156008 0.463804320601246 no 1551 0.481084240135834 2285 723043 SGTC_3275 9138069 49.47 µM 0.0452502824435613 0.464645104484227 no 1552 0.481953907837022 2215 17617007 SGTC_2086 5274770 176.623 µM 0.0440771935765541 0.465097135800638 no 1553 0.482421436001159 2289 689278 SGTC_643 k048-0106 28.4 µM 0.0440113579136333 0.465122505876639 no 1554 0.482447675167649 2297 6763920 SGTC_1769 st044406 64.4 µM 0.0439493598788929 0.46514639723456 no 1555 0.482472384895778 2281 670903 SGTC_1866 st057638 64 µM 0.0434132105177489 0.465353011213888 no 1556 0.482686073579867 2289 688802 SGTC_2525 harmine 47.85 µM 0.0431579967323082 0.465451365330716 no 1557 0.482787793810771 2290 5280953 A monoamine oxidase inhibitor SGTC_630 4356-0227 183 µM 0.0430918952008644 0.465476839838748 no 1558 0.482814139996261 2333 779312 SGTC_964 1287-0107 19.4 µM 0.0429587559857264 0.465528150062751 no 1559 0.482867205718515 2311 51516812 YPR165W RHO1 SGTC_526 4469-0568 170 µM 0.0417478782437848 0.465994833727197 no 1560 0.483349842944366 2319 2901964 SGTC_1082 camptothecin 424.86 nM 0.0416371531935845 0.466037510545717 no 1561 0.483393977472921 2341 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_364 0083-0097 67.7 µM 0.0414869553667062 0.466095402002914 no 1562 0.483453846005512 2282 5207356 SGTC_247 mechlorethamine 29.705 µM 0.0391570296417913 0.466993527395856 no 1563 0.484382596360048 2313 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1997 st073024 93.8 µM 0.0366652911249285 0.467954213265761 no 1564 0.48537594184686 2343 686268 SGTC_294 k038-0071 157 µM 0.0362589924006787 0.468110878948358 no 1565 0.485537923872964 2303 24152826 SGTC_165 k038-0023 64.381 µM 0.0356379758818379 0.468350347707015 no 1566 0.485785513584197 2352 46368543 SGTC_3216 9129716 49.47 µM 0.0351640909996035 0.468533089080366 no 1567 0.485974447871538 2326 8056934 SGTC_196 k015-0023 18.111 µM 0.03313165609238 0.469316919435184 no 1568 0.486784799344825 2319 5211998 SGTC_1745 st081495 74 µM 0.0330585569534618 0.469345113137199 no 1569 0.486813945715815 2336 13842402 YBL026W LSM2 SGTC_541 4513-1321 94 µM 0.0305088735926232 0.470328599017215 no 1570 0.487830608286553 2308 747515 SGTC_278 4092-0821 23.9 µM 0.0299450123900376 0.470546121081775 no 1571 0.488055453617098 2334 877900 SGTC_2505 galangin 7.89 µM 0.0296365897971889 0.470665105714591 no 1572 0.488178441841496 2345 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3082 9117008 49.47 µM 0.0271666235581954 0.471618073797444 no 1573 0.489163418208778 2331 41448529 SGTC_2059 5238311 157 µM 0.0264777138825602 0.471883899740866 no 1574 0.489438154555948 2347 703021 SGTC_3049 9092223 49.47 µM 0.0243200230622638 0.472716557025541 no 1575 0.490298670879932 2335 8623917 SGTC_2884 9058502 51.95 µM 0.0237297508462314 0.472944365201973 no 1576 0.49053408746997 2330 6471554 SGTC_1925 st057770 10.1 µM 0.022329921569973 0.473484647039771 no 1577 0.491092390433901 2356 5989122 SGTC_1793 st048256 72.231 µM 0.0196832978325526 0.474506277484478 no 1578 0.492148007299287 2363 672022 SGTC_2289 7946404 165.07 µM 0.0194730162961225 0.474587456112017 no 1579 0.492231881418609 2352 1246120 YPR165W RHO1 SGTC_1141 3253-0389 52.6 µM 0.018793964317245 0.47484960950923 no 1580 0.492502734375492 2351 5402031 SGTC_2430 5571206 200 µM 0.0180315580601628 0.47514395545704 no 1581 0.492806838904306 2376 1731771 SGTC_1760 st045453 10.4495 µM 0.0177058103994531 0.4752697226106 no 1582 0.492936772673407 2358 3323419 YIL048W NEO1 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.017356448485867 0.475404609674133 no 1583 0.493076126495007 2357 165506 SGTC_2897 9048598 12.99 µM 0.0150505296372824 0.476294984554605 no 1584 0.493995934058053 2375 6467404 SGTC_3245 9134821 49.47 µM 0.0149382747753422 0.476338332116234 no 1585 0.49404071223457 2381 17014901 SGTC_764 1951-2361 146 µM 0.014735811967258 0.476416514462471 no 1586 0.4941214743189 2377 5438930 SGTC_1891 st059073 26.2 µM 0.0134300324718902 0.476920771489447 no 1587 0.494642353276298 2381 688754 SGTC_1756 st041558 35.5 µM 0.0128815891860487 0.47713257664778 no 1588 0.494861131555297 2388 3955792 SGTC_1215 3852-0577 11.2 µM 0.0125604946270374 0.477256584238212 no 1589 0.494989219386023 2383 2884876 SGTC_738 1315-0003 72.4 µM 0.0117491327160097 0.477569944197305 no 1590 0.4953128820384 2377 6251474 SGTC_1373 2887-0003 58.5 µM 0.0114815039738329 0.477673309423363 no 1591 0.495419643256666 2365 776948 SGTC_1646 st011709 75.6 µM 0.00959955238115165 0.478400210415443 no 1592 0.496170391499622 2386 5757843 SGTC_1905 st060207 84.5 µM 0.00936227629337072 0.478491863100924 no 1593 0.496265046708677 2377 1948547 SGTC_1295 1013-0063 9.78 µM 0.00770976308095448 0.479130211014056 no 1594 0.496924280005521 2391 6826038 SGTC_2502 avocadyne acetate 18.59 µM 0.00739177308532853 0.479253053289576 no 1595 0.497051136042644 2397 3952079 SGTC_1106 tegaserod maleate 11.7 µM 0.00652487789949085 0.479587952345468 no 1596 0.497396968801705 2361 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1702 st027038 51 µM 0.00644740456275813 0.479617882559486 no 1597 0.497427875541193 2388 5521182 SGTC_1732 st034308 51.822 µM 0.00575171314979317 0.479886653612187 no 1598 0.49770541109149 2390 830119 SGTC_1256 0570-0116 285 µM 0.00516308347862682 0.480114069943051 no 1599 0.49794023685447 2390 410638 SGTC_2124 5246320 200 µM 0.00454957823668769 0.48035110380723 no 1600 0.498184987144783 2393 579342 SGTC_1301 naphtanilide LB 4.81 µM 0.00362394014754932 0.480708746430129 no 1601 0.498554260217969 2399 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1018 4259-0013 28.1 µM 0.00309352644915338 0.480913691585074 no 1602 0.498765863472321 2375 6801262 SGTC_3023 9089636 49.47 µM 0.00307392219024301 0.480921266520161 no 1603 0.49877368440289 2404 17249241 SGTC_2098 5376439 882.5 nM 0.00247531741472816 0.481152566111959 no 1604 0.499012492234293 2398 2844116 SGTC_2343 7990716 14.84 µM 0.0009297402561106 0.481749802938271 no 1605 0.499629087355483 2403 6456862 SGTC_803 4488-1585 147 µM 0.000870327998881895 0.481772761652803 no 1606 0.499652789407262 2401 747204 SGTC_2912 7964298 10.93 µM 0.000627296237158352 0.481866677192214 no 1607 0.499749745025073 2404 2975850 SGTC_376 3970-0862 59.1 µM -0.00143258188112266 0.482662722358316 no 1608 0.49942848271297 2410 3135186 SGTC_753 1322-0200 289 µM -0.00147831079786612 0.482680395211137 no 1609 0.499410239533968 2412 5403907 SGTC_2479 5617353 43.85 µM -0.00512827025878677 0.484091101735888 no 1610 0.497954125135912 2422 2731746 SGTC_2995 9067767 71.4286 µM -0.00613096148846742 0.484478676743978 no 1611 0.497554115565679 2426 11673567 SGTC_982 1491-0518 27.5 µM -0.00635064249728971 0.484563593059885 no 1612 0.497466477229903 2427 3091256 SGTC_86 0417-1630 471.922 µM -0.00647333622498761 0.484611019855607 no 1613 0.497417530520613 2414 3634867 SGTC_2263 7948595 193.29 µM -0.00691195546723348 0.484780568237938 no 1614 0.497242550680135 2417 2971371 SGTC_2710 st078562 53.7235 µM -0.00769165455982223 0.485081967898893 no 1615 0.496931504046037 2415 17250908 SGTC_22 0964-0034 14.468 µM -0.00831858771764914 0.48532432071073 no 1616 0.496681401920136 2427 138402 SGTC_2942 9052777 62.25 µM -0.00900689003683601 0.485590403166473 no 1617 0.496406819331684 2431 6469503 SGTC_403 arphamenine a 50 µM -0.00902102483788362 0.485595867435621 no 1618 0.496401180591004 2425 5487158 An arginine aminopeptidase inhibitor. SGTC_1109 tnp00067 928.257 nM -0.0103803153575011 0.486121358080122 no 1619 0.495858927687537 2425 676295 SGTC_950 1165-0508 94.1 µM -0.0115381038862116 0.486568968737906 no 1620 0.49539706465416 2431 6148369 SGTC_3296 9122258 64.045 µM -0.012589529563614 0.486975473310216 no 1621 0.494977637038014 2437 4730474 SGTC_3327 9140648 26.9345 µM -0.0126369170781648 0.486993794700093 no 1622 0.49495873365866 2432 8029710 SGTC_2022 5136654 200 µM -0.0134070993359268 0.487291573358263 no 1623 0.494651501450218 2449 1713771 SGTC_143 4032-1194 15.74 µM -0.0139491030039258 0.487501134669686 no 1624 0.494435293499734 2423 1806963 SGTC_1120 ficusin 1.78878 µM -0.0140704217826487 0.487548042063831 no 1625 0.494386899059029 2465 6199 A DNA cross-linker. SGTC_355 1311-2252 105 µM -0.0141185369855568 0.487566645651859 no 1626 0.49436770577677 2434 5338538 SGTC_922 1866-0035 480 µM -0.0147916324387327 0.487826898656185 no 1627 0.494099207599562 2442 3156169 SGTC_59 0330-0160 1.33 µM -0.0153148762788952 0.488029214977076 no 1628 0.493890487160557 2448 4293482 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0160583943328624 0.488316707330845 no 1629 0.493593902871989 2438 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_277 nystatin 15.5 µM -0.0161104696016092 0.488336843240039 no 1630 0.493573130532694 2427 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2759 disulfiram 3.38 µM -0.0166903200951471 0.48856105563777 no 1631 0.493341834765994 2450 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1294 1000-1494 117 µM -0.0169347206884243 0.488655559779767 no 1632 0.49324434681521 2447 712797 YDL207W GLE1 SGTC_788 1182-0090 188 µM -0.0174431593117523 0.488852163447938 no 1633 0.49304153911652 2493 5715185 SGTC_3089 9117425 49.47 µM -0.0179550583057961 0.489050107912949 no 1634 0.492837352950756 2462 9401657 SGTC_543 3844-1095 191 µM -0.0182408721335464 0.489160629457483 no 1635 0.492723348402776 2461 4230703 SGTC_2362 9071156 126 µM -0.0188393904386177 0.489392073596646 no 1636 0.492484615183035 2451 653133 SGTC_2830 7992007 71.43 µM -0.0199806069719587 0.489833386354254 no 1637 0.492029421436243 2433 1952075 SGTC_1492 4158-0558 28.5 µM -0.020505922361103 0.490036532021636 no 1638 0.491819893854904 2459 3967268 SGTC_2267 7931562 200 µM -0.0209363068268805 0.490202968707936 no 1639 0.491648232152687 2439 934880 SGTC_3288 9119690 36.221 µM -0.0210835761876126 0.490259920562768 no 1640 0.491589493143784 2467 17595618 YKL019W RAM2 SGTC_3313 9133968 57.047 µM -0.0223057611606214 0.49073257022456 no 1641 0.491102026642573 2449 1494643 SGTC_679 0422-0091 41.4 µM -0.0230663617503098 0.491026720209844 no 1642 0.490798668988832 2450 627384 YHR062C RPP1 SGTC_2553 4-methylesculetin 85.09 µM -0.0234974884352887 0.491193453664682 no 1643 0.490626720935684 2440 5319502 SGTC_2072 5231554 129 µM -0.0240277288957804 0.491398520377888 no 1644 0.490415245314198 2466 789545 SGTC_349 k015-0014 24 µM -0.0251460260419624 0.491831021204576 no 1645 0.489969244151237 2456 2196908 SGTC_1498 4478-3555 97.6 µM -0.0255088869359923 0.491971359550721 no 1646 0.489824530022556 2442 3437919 SGTC_1008 4106-0037 6 µM -0.025557641433096 0.491990215683258 no 1647 0.489805086131535 2444 2905394 SGTC_2164 5685496 200 µM -0.0259803022202002 0.492153683355927 no 1648 0.489636524849547 2452 759046 SGTC_792 4534-1957 155 µM -0.0263209334203367 0.4922854263448 no 1649 0.489500679119765 2507 1717904 SGTC_3241 9133421 49.47 µM -0.0267188829840094 0.492439338927155 no 1650 0.489341976032589 2450 17018221 SGTC_869 0564-0080 44.1 µM -0.0267195853729359 0.492439610586938 no 1651 0.489341695919956 2495 6843321 SGTC_2154 5570129 200 µM -0.0273261622837162 0.492674214886415 no 1652 0.489099795086077 2449 673366 SGTC_454 lyso-paf C-16 6.67 µM -0.0277097118857331 0.492822560760532 no 1653 0.48894683885715 2471 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_38 0929-0051 58.268 µM -0.0290351229501204 0.49333519887404 no 1654 0.48841828916583 2483 1379719 SGTC_686 1319-0111 510 µM -0.029595025898924 0.4935517596432 no 1655 0.488195016167619 2472 4562600 SGTC_1799 st045822 46.1415 µM -0.0297630417703279 0.493616745647666 no 1656 0.488128017047237 2453 3674992 SGTC_2019 4016004 108 µM -0.0306313634980911 0.493952602054918 no 1657 0.487781764712648 2494 45595336 SGTC_354 2783-3500 4.88 µM -0.0320506510164812 0.494501574528811 no 1658 0.487215828976918 2483 6740761 SGTC_2257 7960413 200 µM -0.0335382002011244 0.495076961391978 no 1659 0.486622701799947 2504 2974689 YIL048W NEO1 SGTC_818 4072-2707 53.5 µM -0.0335494249133265 0.495081303172515 no 1660 0.486618226306258 2469 882871 SGTC_1672 st016598 6.51 µM -0.0345204859647409 0.495456917088626 no 1661 0.486231053322524 2522 4665860 YNL267W PIK1 SGTC_3047 9092122 49.47 µM -0.0350223669507226 0.495651050130815 no 1662 0.486030952782145 2481 17173831 SGTC_398 bronopol 33.3 µM -0.0361504684717816 0.496087415799094 no 1663 0.485581190290889 2476 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1928 4'-methoxychalcone 40.3 µM -0.0370969830124869 0.496453544681261 no 1664 0.485203838790815 2493 641818 SGTC_344 k064-0035 6.43 µM -0.0378684842377967 0.496751977482826 no 1665 0.484896270476056 2476 5088750 SGTC_530 4358-1714 28 µM -0.0386164585438888 0.497041311317213 no 1666 0.484598090029845 2570 1564641 SGTC_2722 naftopidil 47.16 µM -0.0394467775820749 0.497362499822751 no 1667 0.484267092896484 2479 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_649 1123-0311 367 µM -0.0395089110556618 0.497386534700718 no 1668 0.484242324535116 2502 693629 YIL048W NEO1 SGTC_2979 9012552 45.46 µM -0.0397140980716925 0.497465906555593 no 1669 0.484160530954333 2479 17100905 SGTC_2413 inermin 26.06 µM -0.0397739810902202 0.497489070936346 no 1670 0.484136659947001 2501 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3074 9116018 49.47 µM -0.0410077076541809 0.49796631170654 no 1671 0.483644875606484 2471 17027303 SGTC_2415 st077333 57.7 µM -0.0413954163063055 0.49811628915083 no 1672 0.48349033346228 2486 2766255 SGTC_1205 4161-2785 76 µM -0.0438413560563332 0.499062457968452 no 1673 0.482515430696661 2599 3498106 SGTC_1001 4048-4355 44.4 µM -0.0442060418675306 0.499203530848137 no 1674 0.482370083024731 2492 21824233 SGTC_2466 5983409 37.09 µM -0.0446620351885414 0.499379924717274 no 1675 0.482188347507385 2533 2879657 SGTC_2940 9060638 45.86 µM -0.0455010267941488 0.499704475761301 no 1676 0.481853978242256 2519 4027022 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0458862539673068 0.499853495067638 no 1677 0.481700455191021 2501 65057 A dermal irritant. YDR527W RBA50 SGTC_1178 0988-0033 191 µM -0.0462649812249649 0.5 no 1678 0.481549525170551 2554 5392207 SGTC_3013 9080133 71.4286 µM -0.0466585295641842 0.499847761755857 no 1679 0.481392691469095 2548 17050193 SGTC_2402 5553605 200 µM -0.0468695354272161 0.499766137325378 no 1680 0.48130860430341 2526 6758546 SGTC_301 4119-0100 24.5 µM -0.0470010939327438 0.499715245909688 no 1681 0.481256177830821 2494 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2997 9067075 71.4286 µM -0.047311414895899 0.499595202964084 no 1682 0.481132515250088 2532 27209819 SGTC_391 gliotoxin 8.33 µM -0.0479299923045537 0.499355915820218 no 1683 0.480886018225038 2560 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1954 st077032 68.9 µM -0.0504431191968854 0.498383754673376 no 1684 0.479884637976081 2566 698907 SGTC_2332 7982454 138.89 µM -0.0505707426770951 0.498334385869837 no 1685 0.47983378847254 2476 2981748 SGTC_318 1488-0629 67.2 µM -0.0506716673310556 0.498295345035774 no 1686 0.479793576915164 2549 3662576 SGTC_1003 4049-0218 100 µM -0.0528805271195064 0.497440893257643 no 1687 0.478913549896112 2555 295161 SGTC_1462 k081-0014 26.5 µM -0.0532475488196306 0.497298919526772 no 1688 0.478767335422687 2472 3270634 SGTC_2911 7942208 15.64 µM -0.0534123157041021 0.4972351834347 no 1689 0.478701696353971 2539 1243384 SGTC_2585 alliin 100 µM -0.0537361578954654 0.497109913107146 no 1690 0.478572687285972 2544 87310 A garlic compound which reacts with lipids. SGTC_3005 9076496 71.4286 µM -0.0543553408367937 0.496870398332202 no 1691 0.478326029535111 2506 21368410 SGTC_105 0111-0055 734.78 µM -0.0545352871235522 0.496800791011212 no 1692 0.478254347674981 2586 5179370 SGTC_3270 9137563 49.47 µM -0.0547866331185412 0.496703564820852 no 1693 0.478154224817182 2640 17015724 SGTC_2097 5376186 200 µM -0.0560476486204318 0.496215779204518 no 1694 0.47765192434027 2511 742755 SGTC_2408 sulbentine 18.36 µM -0.0564533682478763 0.496058840034882 no 1695 0.477490321495718 2641 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1600 coumarin 106 71.1 µM -0.0586283438197955 0.49521753393637 no 1696 0.476624067201757 2662 100336 A hepatotoxic, DNA x-linker. SGTC_450 aminopyrene 156 nM -0.0597034541118034 0.494801676269853 no 1697 0.476195910330731 2501 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2580 diallyl disulphide 81.36 µM -0.0605878098869941 0.494459607553061 no 1698 0.475843740994734 2547 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1805 st050013 60.3 µM -0.0621529949022787 0.493854204304469 no 1699 0.475220497354237 2575 4037144 SGTC_1142 3253-1408 9.78 µM -0.062716344340954 0.493636307845741 no 1700 0.474996191056631 2493 256655 SGTC_2245 6637752 200 µM -0.0627974242775334 0.493604947303509 no 1701 0.474963908475766 2548 681890 SGTC_2175 5807670 165.306 µM -0.0632544225565384 0.493428187749374 no 1702 0.474781954286211 2519 241186 SGTC_1345 1488-0192 31.4 µM -0.0643992862678305 0.492985378696324 no 1703 0.474326149162359 2526 658348 SGTC_3278 9139605 49.47 µM -0.0646515999048112 0.492887790264962 no 1704 0.474225699914593 2703 7958859 SGTC_1713 st033146 12.748 µM -0.0646709584728619 0.492880302885784 no 1705 0.474217993091588 2535 674619 SGTC_2060 5238662 140 µM -0.0656082500493373 0.49251778648696 no 1706 0.473844860339134 2587 790130 SGTC_888 0916-0002 6.97 µM -0.066188386899602 0.492293409950416 no 1707 0.473613921205951 2691 2802138 YIL048W NEO1 SGTC_425 3825-7017 13.1 µM -0.0676362077812943 0.491733454528041 no 1708 0.473037615870288 2736 3397440 SGTC_2878 9043973 25.97 µM -0.0683457968004233 0.491459021612477 no 1709 0.472755184378605 2684 6465167 SGTC_929 2805-0021 398 µM -0.0684612792511802 0.491414359257498 no 1710 0.472709221204122 2622 3098024 SGTC_304 1310-0298 97 µM -0.0685854108369222 0.491366352005776 no 1711 0.472659815992352 2539 1550234 SGTC_2803 7707263 71.43 µM -0.0689126519887153 0.491239793776285 no 1712 0.472529573815789 2553 2199229 SGTC_993 3909-8757 62.7 µM -0.0701874749761578 0.490746773418083 no 1713 0.472022221630328 2574 4288324 YLR208W SEC13 SGTC_3185 9108267 49.47 µM -0.0708015137895415 0.490509307301513 no 1714 0.471777863510269 2579 4910486 SGTC_2504 purpurogallin 52.29 µM -0.0730876075258016 0.489625240664049 no 1715 0.470868201522715 2574 5281571 An antioxidant. SGTC_2607 solasodine 47.35 µM -0.0745985726304072 0.489040955567385 no 1716 0.470267054918266 2574 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1362 1611-0397 101 µM -0.0747357843454549 0.488987897407164 no 1717 0.470212467742966 2542 27816 SGTC_1643 st009866 20.2 µM -0.0748599002245738 0.48893990342088 no 1718 0.470163090989008 2548 3156273 YOR207C RET1 SGTC_2852 9023854 51.95 µM -0.0752030936474656 0.488807195851045 no 1719 0.470026561476171 2625 19798528 SGTC_3098 9119039 49.47 µM -0.075287689893565 0.488774483985527 no 1720 0.469992907863004 2531 17161528 SGTC_598 3937-0236 20.2 µM -0.075516506059979 0.488686005217862 no 1721 0.469901882549259 2595 1379313 SGTC_62 0180-0423 3.232 µM -0.0769053567928485 0.488148975717045 no 1722 0.469349418033146 2571 30102 YGL099W LSG1 SGTC_1486 3970-0793 4.53 µM -0.0775693290871769 0.487892243844514 no 1723 0.469085320344313 2627 2844330 SGTC_485 niflumic acid 177 µM -0.0799446002388943 0.486973862091949 no 1724 0.468140658730706 2654 4488 A COX2 inhibitor. SGTC_115 0527-0192 112.043 µM -0.0814618278962213 0.486387272619898 no 1725 0.467537340438062 2598 4233931 SGTC_1945 st075991 56.6 µM -0.0816374347114992 0.486319381516063 no 1726 0.467467516019399 2588 1084980 SGTC_1438 4092-1045 4 µM -0.083133702667965 0.485740927748428 no 1727 0.466872613867781 2552 1351342 SGTC_2088 5278280 127.392 µM -0.0832020720737309 0.485714497000161 no 1728 0.466845432588943 2593 791502 SGTC_2895 9054447 58.44 µM -0.0833420395757758 0.485660387528555 no 1729 0.466789786899535 2550 2697450 SGTC_2490 carminic acid 95.39 µM -0.0844825055346958 0.48521950932553 no 1730 0.466336405835871 2530 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1780 st038448 24.544 µM -0.0851217465065166 0.484972401170473 no 1731 0.46608230091892 2758 728868 YDL195W SEC31 SGTC_1163 k060-0048 49.9 µM -0.085741443282569 0.484732853624526 no 1732 0.465835978220196 2540 6809982 SGTC_251 melphalan 456.522 µM -0.0859052111862501 0.484669549065349 no 1733 0.465770884450051 2609 460612 A DNA alkylator. SGTC_440 fluspirilene 35.1 µM -0.0865775915470634 0.48440964419197 no 1734 0.465503639179786 2809 3396 An atypical antipsychotic. SGTC_1372 2752-0194 270 µM -0.0868514116951639 0.484303802434649 no 1735 0.465394810678728 2561 823334 SGTC_1547 harmine 94.2 µM -0.0887008638878826 0.483588949131014 no 1736 0.464659822980205 2560 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0900142944231142 0.483081311697357 no 1737 0.464137927817753 2606 4330530 SGTC_1460 k062-0059 9.15 µM -0.0902409560111064 0.482993710343981 no 1738 0.464047869442536 2508 1373085 SGTC_1396 3511-0007 98.6 µM -0.0903144617931457 0.482965301621831 no 1739 0.464018664133632 2645 X1396 SGTC_1950 st077106 7.18 µM -0.0915259619960712 0.482497090169918 no 1740 0.463537339059594 2642 13831864 SGTC_3144 9087057 49.47 µM -0.0917798060269209 0.482398989482517 no 1741 0.463436494394338 2537 17249618 SGTC_2623 humulene 100 µM -0.092849686561071 0.481985534712609 no 1742 0.463011488650302 2618 6187145 An anti-inflammatory. SGTC_17 0960-0276 49.807 µM -0.0936730895625438 0.481667344225747 no 1743 0.462684423839285 2577 6821114 SGTC_2423 st077119 87.2 µM -0.0940487363611048 0.481522185593301 no 1744 0.462535221127686 2526 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_331 k048-0133 24.5 µM -0.0947129093343838 0.481265539764296 no 1745 0.462271431954894 2561 6813582 SGTC_495 decylubiquinone 155 µM -0.0960670284043218 0.480742313173569 no 1746 0.461733668839625 2627 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2570 licareol 100 µM -0.0961544501369253 0.480708534870426 no 1747 0.461698953323489 2694 443158 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0965348544069532 0.480561554604704 no 1748 0.461547896682779 2619 390807 SGTC_1100 amiodarone 5.07 µM -0.096688715158711 0.480502106772859 no 1749 0.46148680091899 2579 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2198 6589944 200 µM -0.0967025367319276 0.480496766494146 no 1750 0.461481312627008 2607 5290268 SGTC_162 k030-0015 37.8 µM -0.0976976328173734 0.480112297779223 no 1751 0.461086197652018 2630 1809920 YMR134W ERG29 SGTC_1963 st076565 50.3 µM -0.0980462644717408 0.47997760362306 no 1752 0.46094777828952 2590 4914280 SGTC_3172 9105863 49.47 µM -0.0991223605237907 0.479561867422793 no 1753 0.460520559192195 2584 2348785 SGTC_2253 7938677 135.83 µM -0.101161522339026 0.478774124207586 no 1754 0.459711120351283 2786 2301972 SGTC_3000 9075062 71.4286 µM -0.10122954236286 0.47874784898365 no 1755 0.459684122876673 2619 17057871 SGTC_185 k048-0037 25.491 µM -0.101356991648982 0.478698617280624 no 1756 0.459633538142594 2567 6827589 SGTC_435 c-PAF 6.7 µM -0.101903476380774 0.478487522310582 no 1757 0.459416645288578 2581 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_789 1309-1135 70.6 µM -0.103243741946596 0.477969833023737 no 1758 0.458884762162785 2596 3092424 SGTC_3192 9110362 49.47 µM -0.103546499550709 0.477852895368873 no 1759 0.458764623249204 2573 16649480 SGTC_664 1222-0054 14.9 µM -0.10435189439446 0.477541827490314 no 1760 0.458445048447171 2618 6813991 SGTC_491 tetrandrine 80.3 µM -0.104826765840057 0.47735842415728 no 1761 0.458256635492732 2676 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2789 5281112 71.43 µM -0.10490404993632 0.477328576193159 no 1762 0.458225972659304 2643 765948 SGTC_2246 7293507 91.5585 µM -0.105008397905881 0.477288276066678 no 1763 0.458184572499648 2770 887656 SGTC_1202 1988-0068 29.6 µM -0.105116515290304 0.477246520403203 no 1764 0.458141677299453 2610 2850480 SGTC_110 0850-0284 111.64 µM -0.10528233479639 0.477182480276467 no 1765 0.458075889928427 2563 3906265 SGTC_2844 9010103 25.97 µM -0.105328788769129 0.477164539680315 no 1766 0.458057459945877 2760 2480525 SGTC_689 0833-0039 98 µM -0.105842614747112 0.476966102387821 no 1767 0.457853612493918 2660 5374726 SGTC_3211 9128781 49.47 µM -0.108069508343351 0.476106152696517 no 1768 0.456970277641411 2748 17194361 SGTC_1520 flindersine 88 µM -0.108761956213 0.475838775645473 no 1769 0.456695649651391 2877 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1169 aniline yellow 25.8 µM -0.109863105839023 0.475413607767644 no 1770 0.456258971324595 2644 6051 A DNA damaging agent. SGTC_1035 k081-0041 55.2 µM -0.110392477701874 0.47520922049173 no 1771 0.456049059296471 2576 731709 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.110508967380078 0.475164245405052 no 1772 0.456002869244243 2596 97141 SGTC_2374 9071832 200 µM -0.111033334280788 0.47496179837494 no 1773 0.455794956610154 2589 17381698 SGTC_1709 st033179 39.1045 µM -0.111146075761586 0.474918272103346 no 1774 0.4557502559432 2593 573381 SGTC_2441 5730946 39.09 µM -0.111515211182993 0.474775761538187 no 1775 0.455603902026183 2715 1774275 SGTC_3234 9132280 49.47 µM -0.111900112717729 0.474627167653023 no 1776 0.455451303614951 2671 17612295 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.111959205548112 0.474604354771382 no 1777 0.455427876199288 2619 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1633 st005664 67.9 µM -0.112621190100478 0.474348800285141 no 1778 0.45516544232958 2603 2063822 SGTC_1309 pyrazolanthrone 13.4 µM -0.113444187384216 0.474031102694195 no 1779 0.45483920466611 2665 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2158 5657123 3.6195 µM -0.114094007503364 0.47378026748942 no 1780 0.454581636262354 2575 2858827 SGTC_2463 5473429 200 µM -0.114261226964764 0.473715721261282 no 1781 0.454515358774401 2674 5399405 SGTC_1907 st060210 83.7 µM -0.115131014649602 0.473379996899587 no 1782 0.454170638607637 2713 688793 SGTC_853 0419-0306 21 µM -0.115191594413114 0.473356614765527 no 1783 0.454146630506867 2605 762713 SGTC_595 3909-8003 73.7 µM -0.115460254281821 0.473252920501664 no 1784 0.454040161111079 2694 699517 SGTC_2485 5633444 17.78 µM -0.115629809003574 0.473187478641536 no 1785 0.453972968596216 2685 5724239 SGTC_2544 sphondin 68.51 µM -0.115916549455364 0.473076809065483 no 1786 0.453859339772236 2827 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1480 1070-0044 41.2 µM -0.116948797122822 0.472678422790684 no 1787 0.453450314459117 2708 3124987 SGTC_2835 9006588 71.43 µM -0.117074346990673 0.472629969856684 no 1788 0.453400569026874 2842 2345538 SGTC_747 3448-8087 38.7 µM -0.11718720961075 0.472586413604673 no 1789 0.453355851166435 2664 5168703 SGTC_1615 st002656 86.5 µM -0.117346562283404 0.472524916342286 no 1790 0.453292714258053 2590 1584458 SGTC_550 4123-0385 25.7 µM -0.117712601003732 0.472383657439835 no 1791 0.453147691021589 2626 5731123 SGTC_205 1486-1330 71.903 µM -0.11802472575515 0.472263207352674 no 1792 0.45302403324251 2606 4118834 SGTC_2829 7992743 58.44 µM -0.118913900708571 0.47192008541748 no 1793 0.45267178436668 2722 16462845 SGTC_2034 5197015 53.07 µM -0.118950270192782 0.471906051312229 no 1794 0.452657377295741 2741 780676 SGTC_2270 7924575 90.91 µM -0.119689302197589 0.471620884297078 no 1795 0.452364637522939 2837 1262135 SGTC_2625 euphol 100 µM -0.120464235246387 0.471321879933144 no 1796 0.452057704712873 2704 6708538 A triterpene alcohol. SGTC_361 000s-0510 1.45 µM -0.12219833352442 0.470652844871574 no 1797 0.451370973110052 2694 660 SGTC_1031 k035-0009 16 µM -0.123032108929261 0.470331194099504 no 1798 0.451040835931929 2827 5180959 SGTC_1048 3161-0300 24.5 µM -0.123247328998409 0.470248170437039 no 1799 0.450955624052693 2615 2165101 SGTC_636 0kpi-0074 126 µM -0.123357704817719 0.470205592173443 no 1800 0.450911923935109 2681 616434 SGTC_487 nimodipine 119 µM -0.123925935395627 0.469986398555916 no 1801 0.450686958878299 2604 4497 L-type voltage-gated calcium channels inhibitor SGTC_3355 9151058 44.0485 µM -0.125313396487118 0.469451227029569 no 1802 0.450137723461212 2615 17015728 SGTC_3330 9141424 71.43 µM -0.125780728554505 0.469270980069225 no 1803 0.449952748495502 2752 27261020 SGTC_805 3852-0218 479 µM -0.126258749936309 0.469086616824878 no 1804 0.449763553835262 2648 6615355 SGTC_1149 3909-7961 23.3 µM -0.126473391747915 0.469003835943887 no 1805 0.449678605103459 2651 735261 SGTC_412 gemfibrozil 100 µM -0.126473508473063 0.469003790926878 no 1806 0.449678558907806 2626 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3196 9111891 49.47 µM -0.128189196424006 0.468342150232921 no 1807 0.448999624768522 2584 18891510 SGTC_2728 chlorpromazine 9.18 µM -0.128253348026618 0.468317412388881 no 1808 0.448974241501143 2617 2726 A thorazine and dopamine antagonist. SGTC_1829 berberine 14.4 µM -0.129835041743236 0.467707525908495 no 1809 0.448348469126254 2803 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_252 miconazole 1.30953 nM -0.13044874549977 0.467470907742134 no 1810 0.448105701351823 2665 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_442 cape 100 µM -0.130496566727367 0.467452470384545 no 1811 0.448086785135842 2676 5281787 SGTC_1572 epiandrosterone 68.9 µM -0.132002761617347 0.466871796560218 no 1812 0.447491053705228 2657 441302 A steroid. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.132518489063306 0.466672987548514 no 1813 0.447287099917013 2726 5379071 SGTC_1423 4048-0112 5.59 µM -0.13280894594951 0.466561022282898 no 1814 0.447172239596572 2723 X1423 SGTC_2608 thymoquinone 42.66 µM -0.132943955218496 0.466508979835734 no 1815 0.447118852086452 2606 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2537 larixol 68.93 µM -0.133078773256716 0.466457011674295 no 1816 0.447065541152031 2619 6708759 SGTC_507 nimesulide 162 µM -0.133984036594266 0.466108075663379 no 1817 0.44670759878149 2830 4495 A COX2 inhibitor. SGTC_14 0354-0009 295 µM -0.134090139597489 0.46606717969669 no 1818 0.446665648344631 2611 1713507 SGTC_1466 k213-0079 57.5 µM -0.134219209062139 0.466017432101331 no 1819 0.44661461835597 2613 3657981 SGTC_2471 5466956 24.79 µM -0.13468270906717 0.465838788414444 no 1820 0.446431372390559 2689 724419 SGTC_1111 tnp00062 510.699 nM -0.134753789526999 0.465811392959139 no 1821 0.446403271551499 2768 676306 SGTC_1234 0326-0494 15.5 µM -0.135328166953912 0.465590025400956 no 1822 0.44617620795505 2759 1547813 SGTC_1757 st041620 31.8375 µM -0.137743495900369 0.464659264440631 no 1823 0.445221571132008 2727 5289815 SGTC_2932 9016711 44.54 µM -0.137795154015455 0.464639359781313 no 1824 0.445201157180321 2708 7117328 SGTC_1716 st033144 30.6155 µM -0.138567273967175 0.464341860765389 no 1825 0.444896052682325 2722 674617 SGTC_2035 5154463 94.595 µM -0.139244783779735 0.464080831597357 no 1826 0.444628360421095 2749 2769623 SGTC_1065 prochlorperazine maleate 2.48 µM -0.13933921990074 0.464044448726409 no 1827 0.4445910495784 2658 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3127 9126946 49.47 µM -0.139755112224626 0.463884223821726 no 1828 0.444426740193505 2756 27243249 SGTC_1382 3002-2117 298 µM -0.140192607099363 0.463715682732432 no 1829 0.444253906450535 2717 1497314 SGTC_3217 9129673 49.47 µM -0.141059766548757 0.463381636382638 no 1830 0.443911363708876 2797 17248312 SGTC_1931 st074438 57.1 µM -0.141510674465319 0.463207948245511 no 1831 0.443733263948607 2612 2787313 SGTC_264 promethazine 12.5 mM -0.141580538885404 0.463181037344298 no 1832 0.443705669892387 2648 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_758 0868-0029 16 µM -0.142359135142625 0.462881143229559 no 1833 0.443398169503218 2791 762687 SGTC_1526 st051518 75 µM -0.143663442706684 0.462378806764816 no 1834 0.442883120081961 2731 673993 SGTC_170 4197-0004 226 µM -0.14428578969882 0.462139139310189 no 1835 0.442637399533513 2800 218692 SGTC_1956 st077085 54 µM -0.145028587208925 0.461853104047519 no 1836 0.442344150535517 2705 24208685 SGTC_2419 paclitaxel 166.5 µM -0.146718125570602 0.46120257305535 no 1837 0.441677255647601 2618 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1808 st050063 61.5 µM -0.148528922193417 0.460505468705615 no 1838 0.440962681240046 2720 4011993 SGTC_1619 st003326 88.7 µM -0.150984251634084 0.459560432103859 no 1839 0.439994069426397 2840 2849032 SGTC_1028 k015-0029 4.8 µM -0.151042809718958 0.459537896334753 no 1840 0.439970972995733 2661 4588309 SGTC_2057 5236571 38.335 µM -0.15134029747682 0.459423411754639 no 1841 0.439853641280718 2759 54684039 YBR257W POP4 SGTC_3041 9091929 49.47 µM -0.151451951698457 0.459380443840313 no 1842 0.439809605263952 2803 25236887 SGTC_3250 9135583 49.47 µM -0.154270399911892 0.458295978390858 no 1843 0.438698267670963 2824 7699353 SGTC_2165 5727197 32.143 µM -0.154538087879596 0.458192995046167 no 1844 0.4385927410628 3093 1361712 SGTC_1280 0880-0253 10.1 µM -0.156777749155298 0.457331476322218 no 1845 0.437710004788168 2717 6836607 SGTC_2663 amphotericin b 100 µM -0.157280738628916 0.45713802143009 no 1846 0.437511799835965 2685 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.1574034453908 0.457090828694749 no 1847 0.43746344913795 2690 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1138 3761-0006 1.03 µM -0.158334553764792 0.456732746342781 no 1848 0.437096590791134 2672 12061087 SGTC_1676 st018489 23.4 µM -0.158736879413672 0.45657803222581 no 1849 0.436938090487969 2754 3696235 SGTC_1746 st038117 42 µM -0.159795282507905 0.456171055366868 no 1850 0.436521170171752 2796 2898218 SGTC_3315 9136395 68.55 µM -0.159992078408057 0.456095388519398 no 1851 0.436443657174984 2710 16876844 SGTC_946 3434-1334 87.4 µM -0.16009354238381 0.456056376849038 no 1852 0.436403693998885 2819 4047976 SGTC_1340 1486-1359 257 µM -0.161740375003649 0.455423249145531 no 1853 0.435755154233669 2735 4309068 SGTC_3188 9110789 49.47 µM -0.16360173201968 0.454707783515015 no 1854 0.435022340562223 2840 849217 SGTC_500 h-89 112 µM -0.166940006553169 0.453424992055032 no 1855 0.433708627072698 2884 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_290 2043-6722 48.1 µM -0.167879766807008 0.453063959489046 no 1856 0.433338933977286 2767 773758 YLR208W SEC13 SGTC_65 0798-0905 34.986 µM -0.168207818438269 0.45293793931362 no 1857 0.433209895180078 3103 3602145 SGTC_1497 4476-2978 41.3 µM -0.168562867041268 0.45280155366352 no 1858 0.433070245173453 2785 1528379 SGTC_1291 0993-0025 5.79 µM -0.169068015266642 0.452607519494774 no 1859 0.432871571423541 2819 4353356 SGTC_2681 menadione 3.18 µM -0.169251413182315 0.452537076707793 no 1860 0.432799445599077 2756 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_81 0411-0046 9.971 µM -0.170630599483211 0.452007381911693 no 1861 0.432257117924596 2691 12925265 SGTC_102 gallobenzophenone 83.616 µM -0.17067613761276 0.451989893840486 no 1862 0.432239213458797 2857 70837 SGTC_546 peri-Naphthalide 147 µM -0.171074798863976 0.451836799387067 no 1863 0.432082475664465 2807 223824 A penicillin ester. SGTC_3207 9114163 49.47 µM -0.171124920368818 0.451817552162763 no 1864 0.432062770632357 2947 849233 SGTC_2667 digitoxin 100 µM -0.171406264834041 0.451709514811861 no 1865 0.431952164527469 2780 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_525 k781-2675 26.7 µM -0.172991670364677 0.451100780110579 no 1866 0.431328987499899 2700 3651118 YDL195W SEC31 SGTC_24 0417-1663 219 µM -0.173916824936926 0.450745609398539 no 1867 0.430965414874104 2788 4329390 SGTC_11 0438-0307 1.3 µM -0.174155055148595 0.450654158196813 no 1868 0.430871803238069 2822 4011476 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.174998818521253 0.450330277583645 no 1869 0.430540280971755 2736 689007 SGTC_2822 7994718 71.43 µM -0.175606664518141 0.450096974910432 no 1870 0.430301483097054 2673 1018011 SGTC_1778 st046819 58.9 µM -0.175649490646647 0.450080538089933 no 1871 0.430284659419854 2732 671715 SGTC_2964 9083345 53.42 µM -0.176904430394313 0.449598925886343 no 1872 0.429791729279732 2766 17741579 SGTC_821 1114-0266 29.2 µM -0.177267607420711 0.449459562106932 no 1873 0.429649096675383 2795 3123235 SGTC_2030 5175110 200 µM -0.178236771802976 0.449087690258935 no 1874 0.429268516164565 2844 2831986 SGTC_2596 sinensetin 100 µM -0.178520258351812 0.448978923892501 no 1875 0.429157206432823 2789 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_961 1252-1571 372 µM -0.179067341887044 0.448769033110304 no 1876 0.428942412450017 2854 6813498 SGTC_771 0250-0039 27.3 µM -0.181907654926847 0.447679567421758 no 1877 0.427827598483916 2722 3005115 SGTC_1828 st055811 49 µM -0.181970476423214 0.447655475259797 no 1878 0.427802947720541 2862 5877589 SGTC_1422 4031-0024 15.5 µM -0.182469358155897 0.447464160040601 no 1879 0.427607199652236 2728 782427 SGTC_604 1000-0114 314 µM -0.184568426291333 0.446659326758901 no 1880 0.426783776293404 2873 1572745 SGTC_2365 9042475 200 µM -0.185213389836672 0.446412076163295 no 1881 0.426530833608177 2818 6464479 SGTC_1855 st056195 39.6 µM -0.185689367404519 0.446229620697894 no 1882 0.42634418344539 2919 4028379 SGTC_1744 st037937 38.9 µM -0.186222576199283 0.446025240429871 no 1883 0.426135110183456 2904 1016152 SGTC_146 3448-8650 53.125 µM -0.186327847910194 0.445984891212474 no 1884 0.426093835184284 2775 2891488 YIL048W NEO1 SGTC_680 0417-1641 114 µM -0.186908522151723 0.445762336723682 no 1885 0.425866178620644 2717 2835990 SGTC_2765 myclobutanil 7.74 µM -0.187423477740064 0.445564984458079 no 1886 0.425664308088674 2836 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_130 0136-0219 337.655 µM -0.187492031470047 0.445538712851523 no 1887 0.42563743543765 2709 234244 SGTC_1987 st072290 61.9 µM -0.189691364724761 0.444695997581278 no 1888 0.424775493952678 2794 54697379 SGTC_697 0508-1955 564 µM -0.190444235993401 0.444407578236209 no 1889 0.424480518301407 2839 6243113 SGTC_873 0591-4978 488 µM -0.190504501793995 0.4443844921297 no 1890 0.424456907931637 2962 3305145 SGTC_590 k048-0076 22.4 µM -0.190774627489544 0.44428101701214 no 1891 0.424351083953331 2853 6832814 SGTC_3093 9117344 49.47 µM -0.191446688065554 0.444023592068602 no 1892 0.424087822334477 2890 24824913 SGTC_2808 7946468 45.46 µM -0.192154925192315 0.44375233567813 no 1893 0.42381042618296 2822 2970879 SGTC_404 fumagillin 50 µM -0.192297850323567 0.443697598227216 no 1894 0.423754451085178 2787 12015870 A methionine aminopeptidase binder. SGTC_511 blebbistatin 171 µM -0.192892760483587 0.443469771152543 no 1895 0.423521477429982 2890 3476986 A myosin inhibitor. SGTC_1898 st060199 18.6 µM -0.193445247514595 0.443258207191333 no 1896 0.423305141099483 2739 688866 SGTC_1239 0337-0584 35.4 µM -0.193779693356639 0.44313014563829 no 1897 0.423174193986078 2912 914301 YML130C ERO1 SGTC_67 0335-0847 266 µM -0.194756241620017 0.442756252810527 no 1898 0.422791890185913 3138 4552207 YOR254C SEC63 SGTC_2121 5257820 149.641 µM -0.196278629963031 0.442173474983839 no 1899 0.422196043438349 2887 791256 SGTC_757 1066-0008 322 µM -0.196467553625172 0.442101162768644 no 1900 0.422122113098296 2907 6842497 SGTC_1853 st056710 91.2 µM -0.198360653229971 0.441376668946012 no 1901 0.421381449953566 2936 269167 SGTC_3280 9140961 49.47 µM -0.199753678464457 0.44084367991267 no 1902 0.420836615169429 2739 4901226 SGTC_980 1473-0395 201 µM -0.200628345987341 0.44050907577527 no 1903 0.420494595907875 2760 768876 SGTC_2825 7998094 58.44 µM -0.201350109847228 0.440232996922589 no 1904 0.420212411402147 2843 2987815 SGTC_2705 st078069 42.8 µM -0.203394928984416 0.439450999964972 no 1905 0.419413181529761 2843 1530061 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.2062096946771 0.438374940531259 no 1906 0.418313557665331 2758 1377 SGTC_510 ag-490 170 µM -0.207334415416984 0.437945096878031 no 1907 0.417874349216192 2836 5328779 SGTC_725 1497-0963 19 µM -0.207461152655898 0.43789666525909 no 1908 0.41782486417113 2898 3549977 SGTC_1152 3909-8331 15.9 µM -0.208249017966048 0.437595609747332 no 1909 0.41751726832825 2783 16001939 SGTC_381 3461-2219 42.7 µM -0.208273994053179 0.437586066588227 no 1910 0.417507518068831 2895 2883159 SGTC_814 3342-0569 96 µM -0.208384821259436 0.437543720855057 no 1911 0.417464253536558 2763 4346283 SGTC_1671 st016596 74.5 µM -0.208408949604465 0.437534501801471 no 1912 0.417454834487563 2806 2829167 SGTC_1326 1431-2094 10.8 µM -0.208535230184177 0.437486252570965 no 1913 0.417405538760044 2743 616278 SGTC_3096 9117468 49.47 µM -0.208706057590514 0.437420984387225 no 1914 0.417338855502757 2923 41316311 SGTC_3304 9125678 46.087 µM -0.209313527739834 0.437188901516951 no 1915 0.417101746030567 2804 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_583 1488-1091 88.9 µM -0.209825564299119 0.43699329565957 no 1916 0.416901909879446 2827 4303273 SGTC_3121 9125696 49.47 µM -0.210536233793841 0.436721834492606 no 1917 0.416624587426958 2761 1235365 SGTC_1748 st037455 53.6035 µM -0.211543847735201 0.436336997739344 no 1918 0.416231460370867 2962 580690 SGTC_2923 7992654 58.14 µM -0.212713196889281 0.435890465216653 no 1919 0.415775336348302 2825 2985126 SGTC_415 dibenzyl ketone 100 µM -0.213909422211485 0.435433754200434 no 1920 0.415308846216789 2857 7593 SGTC_3181 9108277 49.47 µM -0.214056854246117 0.435377471560462 no 1921 0.415251360623688 2799 17097298 SGTC_3145 9085516 49.47 µM -0.214297307639206 0.435285680535261 no 1922 0.415157608732949 2864 25236195 SGTC_3226 9131256 49.47 µM -0.214317840678533 0.435277842384729 no 1923 0.415149603200475 2782 17178073 SGTC_3283 9109332 35.8195 µM -0.214905307697273 0.435053597282517 no 1924 0.414920573315911 2752 17027281 SGTC_2833 9001315 45.46 µM -0.215233714113671 0.434928248652383 no 1925 0.414792553388975 2815 2989378 SGTC_2353 9059630 146.67 µM -0.215244459134369 0.434924147522515 no 1926 0.414788364900215 2901 4779114 SGTC_2316 5844804 197.44 µM -0.215320436600219 0.434895148852676 no 1927 0.414758748596978 2914 776813 SGTC_3058 9093861 49.47 µM -0.215496946262709 0.43482778094775 no 1928 0.414689946334225 2966 17217477 SGTC_2810 7959871 45.46 µM -0.215577526309193 0.434797026835915 no 1929 0.414658537651549 2893 2974535 SGTC_2024 5144227 134 µM -0.215750710197776 0.434730930955959 no 1930 0.414591035469135 2943 3475211 SGTC_1451 4152-0210 104 µM -0.216994458747579 0.434256306233502 no 1931 0.414106331670363 2950 659563 SGTC_798 1287-0182 476 µM -0.217320045179943 0.434132075381896 no 1932 0.41397946828646 2962 1649755 SGTC_1024 4507-0395 26 µM -0.218379570080118 0.433727847850905 no 1933 0.413566691064969 2965 4201836 SGTC_616 4092-0450 108 µM -0.218978008206052 0.43349956369713 no 1934 0.413333589471051 2852 787165 SGTC_259 usnic acid 108.925 µM -0.220055007508427 0.433088780377702 no 1935 0.41291415735086 2986 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2874 9043904 71.43 µM -0.22005649937117 0.433088211409418 no 1936 0.412913576421026 2860 4463428 SGTC_1792 st045773 43.6 µM -0.220223166522603 0.433024648578191 no 1937 0.412848677603019 2782 2919270 SGTC_46 0329-0187a 2.197 µM -0.220811010706619 0.432800472830333 no 1938 0.412619794940951 2883 46494817 SGTC_1943 st076331 65.2 µM -0.221885112596501 0.432390917482083 no 1939 0.41220166005297 2890 24208415 SGTC_2036 5160441 105 µM -0.22284585389354 0.43202464808418 no 1940 0.411827739482265 2855 134534 YIL048W NEO1 SGTC_3284 9108171 64.8615 µM -0.222962343028701 0.431980242169352 no 1941 0.411782407338514 2911 8687505 SGTC_2379 9035213 200 µM -0.224031980045911 0.431572534427635 no 1942 0.411366209564934 2937 646551 SGTC_2218 6965428 192.983 µM -0.226234344681621 0.430733301039083 no 1943 0.410509579895309 2796 675684 SGTC_2695 st077686 51.995 µM -0.226563322450353 0.430607967475278 no 1944 0.410381657547404 2860 2876092 SGTC_639 0833-0042 114 µM -0.226887227523156 0.430484573329794 no 1945 0.410255717021967 2819 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1053 3366-3204 134 µM -0.227716638844035 0.430168633635471 no 1946 0.409933268161199 2855 3632071 YPR165W RHO1 SGTC_854 0422-0053 192 µM -0.229125442630441 0.429632094086957 no 1947 0.409385709528663 2826 3596728 SGTC_263 alizarin 107.927 µM -0.230526539652131 0.429098618517592 no 1948 0.408841321548272 2800 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_153 4077-0274 519.67 µM -0.23316800747135 0.428093217710547 no 1949 0.407815473774239 3104 3121976 SGTC_2222 6885208 172.143 µM -0.233252927010644 0.428060903171304 no 1950 0.407782504629468 2853 609514 SGTC_1113 artemisinin 1.17947 µM -0.234754482393394 0.427489594289884 no 1951 0.407199649139338 2922 2240 An anti-malaria and mitochondrial poison. SGTC_2847 9005661 71.43 µM -0.236134655937885 0.426964602581939 no 1952 0.406664091325519 2875 2991449 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.236310775141841 0.426897619479952 no 1953 0.406595763168211 2809 688803 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.236908053860877 0.426670473239799 no 1954 0.406364060878005 2814 229346 A bile salt which induces apoptosis. SGTC_1870 st057514 26.5 µM -0.237117692931096 0.426590752861726 no 1955 0.406282743377417 2774 5393161 SGTC_3268 9137683 49.47 µM -0.23722813242063 0.426548756753581 no 1956 0.406239906312266 2798 1953228 SGTC_1449 4112-4002 201 µM -0.238670710615907 0.426000273554361 no 1957 0.405680465001454 2863 2059539 SGTC_1647 st011722 22.4 µM -0.238721747423707 0.425980871445588 no 1958 0.405660676112509 2994 2854783 SGTC_1483 3453-0561 55.9 µM -0.239475951842565 0.425694174658438 no 1959 0.405368270840363 2923 4546991 SGTC_260 nsc-65238 3.989 µM -0.240483156772606 0.425311365707991 no 1960 0.404977859574546 2944 3246252 SGTC_799 1310-0557 151 µM -0.240526705774742 0.42529481559925 no 1961 0.404960981305391 2981 5354492 SGTC_3062 9077494 49.47 µM -0.240951018230202 0.425133569263023 no 1962 0.404796539956163 2954 16459633 SGTC_1262 0737-0114 49.6 µM -0.241231911855409 0.425026831539944 no 1963 0.404687689502428 2961 765919 SGTC_3071 9117417 49.47 µM -0.24163566810631 0.424873416459738 no 1964 0.404531240877721 2902 45595590 YGL055W OLE1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.242214628313226 0.424653449072276 no 1965 0.404306930364219 2853 115019 SGTC_678 1218-2179 85.9 µM -0.242376705784135 0.424591874329297 no 1966 0.404244141213014 2831 6820081 YOR116C RPO31 SGTC_2524 avocatin b 10.57 µM -0.242383403025567 0.424589330024388 no 1967 0.404241546740732 2943 6710748 SGTC_1637 st007924 17.4 µM -0.242493634969427 0.424547452983718 no 1968 0.404198844133615 2820 683336 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.243306602396844 0.424238633542433 no 1969 0.403883945039577 2821 91467 include heat shock SGTC_2605 digitonin 300 nM -0.243979400068145 0.423983095119765 no 1970 0.403623387129387 2910 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2643 anethole 100 µM -0.24538084080893 0.423450910111171 no 1971 0.403080781217202 2892 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_246 cycloheximide 667 µM -0.245752821464531 0.423309677079436 no 1972 0.4029367900759 2830 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3159 9100096 49.47 µM -0.251313504546456 0.421199590062961 no 1973 0.400785867514099 2757 25236875 SGTC_1016 4226-1401 38 µM -0.251323626843487 0.421195751044811 no 1974 0.400781954837963 2798 2901613 SGTC_1327 1436-0082 2.18 µM -0.251692053779115 0.421056025244924 no 1975 0.40063954974244 2885 15992205 SGTC_2925 9010536 32.5 µM -0.253536845775717 0.420356538336397 no 1976 0.399926696110122 2913 2994177 SGTC_1844 rapamycin 4 nM -0.253801581836015 0.420256179356129 no 1977 0.399824425661667 2821 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1939 st074455 53.6 µM -0.253823653761622 0.420247812328289 no 1978 0.399815899344559 3087 1644229 SGTC_2394 5221648 200 µM -0.253986285418237 0.420186163014435 no 1979 0.39975307670775 2979 788586 SGTC_1429 4049-0205 9.46 µM -0.254082725211145 0.420149606191556 no 1980 0.399715824410747 2856 22774478 SGTC_884 0851-0618 334 µM -0.254159450478209 0.420120522921423 no 1981 0.39968618799745 2997 9642473 SGTC_2120 5538279 151.968 µM -0.254880463809963 0.419847238907035 no 1982 0.399407712835581 2893 2058197 SGTC_1717 st033143 58.0435 µM -0.257388874715936 0.418896783652071 no 1983 0.398439295172966 3032 674616 SGTC_1241 0364-0022 50.8 µM -0.258303723807307 0.418550258098208 no 1984 0.398086256289817 2915 4563895 SGTC_2871 9038510 12.99 µM -0.259560394235664 0.418074360905576 no 1985 0.397601445114945 3049 4945164 SGTC_555 4296-0685 37 µM -0.259923272747387 0.417936962222996 no 1986 0.39746147951868 2891 2908540 YHR072W ERG7 SGTC_2540 epiandrosterone 100 µM -0.260021276377468 0.417899856287703 no 1987 0.397423680875991 2891 441302 A steroid. SGTC_2461 5755302 26.15 µM -0.261343555935161 0.417399289070919 no 1988 0.39691379027154 3013 2788904 SGTC_1700 st030840 7.9285 µM -0.261784508586206 0.417232390063019 no 1989 0.3967437915205 2966 5499307 SGTC_2898 9056270 58.44 µM -0.262520243633651 0.416953950180545 no 1990 0.396460190164601 2850 19154699 SGTC_1798 st045719 60.953 µM -0.262817569343067 0.416841438689651 no 1991 0.396345596537964 2866 3980186 SGTC_2 0422-0095 29 µM -0.264869341639649 0.41606521044817 no 1992 0.395555058438106 2889 6790840 SGTC_368 fentichlor 4.58 µM -0.265110742119358 0.415973905074586 no 1993 0.39546207616165 2943 7329 A pesticide. SGTC_1391 3442-0225 151 µM -0.265450336238928 0.415845467407941 no 1994 0.395331281880152 2867 5227075 SGTC_1761 st044296 37 µM -0.265845335547222 0.415696086290212 no 1995 0.395179163187606 2858 1826700 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.266106684450838 0.415597255871982 no 1996 0.395078523553701 2949 279621 SGTC_1398 3558-0053 112 µM -0.267039825721281 0.415244427354173 no 1997 0.394719248813953 2831 4532369 SGTC_895 0964-0006 13.7 µM -0.267283809734991 0.415152186216684 no 1998 0.394625325705567 3016 6738897 SGTC_2914 7968218 45.32 µM -0.267776487281923 0.414965937711935 no 1999 0.39443568520753 2976 2977111 SGTC_690 glyoxal 20.3 µM -0.267829044494265 0.414946070464343 no 2000 0.394415456461954 2896 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2626 ethyl orsellinate 100 µM -0.267922905579852 0.414910590405514 no 2001 0.394379330976888 2858 75653 A natural product. SGTC_2312 7706453 155.7 µM -0.271312294788537 0.413629847988008 no 2002 0.393075425559115 2924 976098 SGTC_208 k072-0098 12.366 µM -0.272602091928459 0.413142715128736 no 2003 0.39257955185068 2875 5948901 SGTC_2420 aureobasidin a 50 nM -0.272820265310295 0.413060328220715 no 2004 0.392495690416163 3160 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_765 1319-0117 244 µM -0.273219392781494 0.412909619112428 no 2005 0.392342286811106 2874 3487746 YGL099W LSG1 SGTC_672 1441-0018 53.7 µM -0.274586078452822 0.412393660834855 no 2006 0.391817131573114 2879 251141 SGTC_1360 1598-0022 39.8 µM -0.276029373335165 0.411848944986289 no 2007 0.391262752829346 3013 761525 SGTC_2447 5741742 33.78 µM -0.276513036247801 0.411666443058384 no 2008 0.391077024173121 2974 1776504 SGTC_2967 9089538 49.85 µM -0.276872605996613 0.411530777944454 no 2009 0.390938963924002 3130 728216 SGTC_2073 5212005 126 µM -0.27698015566134 0.411490201675287 no 2010 0.390897671869584 2833 691789 SGTC_1369 1866-0067 208 µM -0.277047822994328 0.411464672672035 no 2011 0.390871692658905 3043 3531355 SGTC_1605 st000082 49.1 µM -0.27770895413004 0.411215266015308 no 2012 0.390617893237685 3015 1114022 SGTC_2497 7-hydroxyflavone 100 µM -0.280106712334029 0.410311031841229 no 2013 0.389697817533056 3069 5281894 SGTC_696 1560-0013 611 µM -0.281199900407174 0.409898930475072 no 2014 0.38927854052201 3095 1650269 SGTC_1282 0886-0010 32.4 µM -0.281238143609312 0.409884515654914 no 2015 0.389263875206449 3064 2836211 YNL267W PIK1 SGTC_3350 9150499 3.57 µM -0.281688206559297 0.409714884818886 no 2016 0.389091299130129 2883 4910996 YPR165W RHO1 SGTC_1114 scopoletin 1.73284 µM -0.282012904509816 0.409592515130375 no 2017 0.388966807689684 3034 5280460 A coumarin with genotoxic properties. SGTC_1936 st074407 74.3 µM -0.28270709854369 0.409330922130953 no 2018 0.388700687147503 2906 809813 SGTC_2398 5228213 48.84 µM -0.282756642612629 0.409312253991297 no 2019 0.388681696333922 3112 80771 YMR134W ERG29 SGTC_2082 5219693 150 µM -0.285886136120652 0.408133483456785 no 2020 0.387482666283758 2904 2834649 SGTC_1167 k781-0610 148 µM -0.286198676166232 0.408015806034966 no 2021 0.387362978812309 2960 4525169 SGTC_2529 gangaleoidin 93.61 µM -0.287100610551958 0.407676256705422 no 2022 0.387017642347881 2885 4565183 SGTC_3213 9129884 49.47 µM -0.287467105355803 0.407538302980818 no 2023 0.38687734279537 3020 17190742 SGTC_592 k241-0073 46.5 µM -0.288116504906957 0.407293888155307 no 2024 0.386628779491354 3027 4230158 SGTC_3012 9080433 71.4286 µM -0.289597462258907 0.406736634659636 no 2025 0.386062104335823 3021 17688859 SGTC_2489 cantharidin 73.42 µM -0.290282415483334 0.40647896476719 no 2026 0.385800095188856 2890 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2639 lactacystin 53 µM -0.290422124157821 0.406426413271738 no 2027 0.385746660047692 3064 3870 A proteasome inhibitor. SGTC_1060 3448-7350 82 µM -0.291442843576648 0.406042520292607 no 2028 0.385356325751295 3046 570178 SGTC_2378 9074213 121.43 µM -0.29150226135374 0.406020176021425 no 2029 0.385333607314204 2918 657714 SGTC_1236 0330-0013 258 µM -0.291804172601972 0.405906645929442 no 2030 0.385218177375109 2955 4617066 SGTC_266 formosanin C 406 nM -0.291906838779409 0.405868041351228 no 2031 0.385178927259983 3029 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1759 st043059 70 µM -0.293027055228508 0.405446876662839 no 2032 0.384750735914237 2913 669426 SGTC_1790 st045711 43.5 µM -0.295309514408157 0.404589085967659 no 2033 0.383878724505819 3097 585119 SGTC_2670 beta-carotene 100 µM -0.295685919584884 0.404447669806141 no 2034 0.383734975585057 3040 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_535 2293-4129 48.2 µM -0.29603274549048 0.404317377683875 no 2035 0.383602537132174 3082 396118 YIL048W NEO1 SGTC_2846 9008642 19.48 µM -0.296216998775059 0.404248163549544 no 2036 0.383532183961452 3055 2992898 SGTC_591 4299-0174 154 µM -0.297736296150705 0.403677558970341 no 2037 0.382952219360617 2985 5509088 SGTC_3139 9095020 49.47 µM -0.2978188964533 0.403646542525788 no 2038 0.38292069567896 2828 25236292 SGTC_3220 9131269 49.47 µM -0.29798586933538 0.403583845996712 no 2039 0.382856974310093 2908 17722206 SGTC_465 cgp-37157 41 µM -0.29835238945514 0.403446230307359 no 2040 0.382717111437142 2991 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2003 4023581 200 µM -0.29891422265896 0.403235304490537 no 2041 0.382502747428587 3085 16641307 SGTC_3309 9129340 25.759 µM -0.299947541912284 0.402847444907304 no 2042 0.382108584843945 2976 17158987 SGTC_565 1418-0001 44.5 µM -0.300536836731772 0.402626294045828 no 2043 0.38188385131864 3106 2862145 SGTC_2301 7769476 200 µM -0.300949967928157 0.402471272531526 no 2044 0.381726323294637 2991 977820 SGTC_137 0438-0332 85.389 µM -0.302571155737695 0.401863093604753 no 2045 0.381108349517811 3007 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_812 4251-0442 148 µM -0.303260121161858 0.401604704188088 no 2046 0.380845817356465 3073 5723007 SGTC_428 3448-4153 16.5 µM -0.303317121353086 0.401583328775922 no 2047 0.380824099732493 2874 3834874 SGTC_3168 9103419 49.47 µM -0.304253024544628 0.401232401645056 no 2048 0.380467565310105 3013 16649256 SGTC_948 3448-0295 75.3 µM -0.304411494431149 0.401172989507513 no 2049 0.380407205892291 2919 678569 SGTC_1684 st024538 14.6195 µM -0.304620799701692 0.40109452211692 no 2050 0.380327488304679 2940 6732859 SGTC_1058 3448-5425 97.3 µM -0.304815055428949 0.401021700286413 no 2051 0.380253507147324 2934 7279705 SGTC_1548 st061468 90.8 µM -0.306351786480643 0.400445737934538 no 2052 0.379668406716219 3063 390799 SGTC_1873 rapamycin 2 nM -0.307075823153137 0.400174446009605 no 2053 0.379392829790537 2958 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1290 0986-0249 10.2 µM -0.308180058853974 0.399760788715014 no 2054 0.378972662624301 3009 53329 SGTC_904 1141-0088 396 µM -0.308340577477841 0.399700666249917 no 2055 0.378911596381266 2995 1378119 SGTC_958 1222-0007 33 µM -0.30951029663986 0.39926261826351 no 2056 0.378466690427975 3125 7312461 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.309760485634541 0.3991689414609 no 2057 0.378371551232219 2998 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_785 1270-0111 65.3 µM -0.309995470240322 0.399080962836275 no 2058 0.3782822005132 2907 6741994 SGTC_410 α-linolenic acid 100 µM -0.312291761994224 0.398221497873641 no 2059 0.377409400095307 3069 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1984 st072354 53.1 µM -0.312734792224134 0.398055735472862 no 2060 0.377241080051127 2928 5762938 SGTC_1559 coumarin 343 70.1 µM -0.313704183275868 0.397693096244488 no 2061 0.376872861629042 3115 108770 A hepatotoxic, DNA x-linker. SGTC_2602 kawain 100 µM -0.314713053970461 0.397315781949202 no 2062 0.376489765954615 2978 5369129 SGTC_1067 clotrimazole 1.36 µM -0.315357916609737 0.397074655766335 no 2063 0.376244957740505 2979 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2206 7254556 146.969 µM -0.315434525234311 0.397046012983536 no 2064 0.376215878232285 3006 4398905 SGTC_2477 5967686 25.23 µM -0.315561437682052 0.396998563599429 no 2065 0.376167705678328 2917 776118 SGTC_3319 9138450 16.7555 µM -0.315571663371267 0.396994740536827 no 2066 0.376163824365526 2956 2029690 SGTC_443 clozapine 122 µM -0.315856152503338 0.39688838299511 no 2067 0.376055847296509 3017 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1772 st048439 82.2 µM -0.316195426303721 0.396761553986176 no 2068 0.37592708954227 3048 2927068 YDL195W SEC31 SGTC_181 1447-1644 8.07 µM -0.316606913048612 0.396607744632756 no 2069 0.375770944799042 3061 534600 SGTC_39 0986-0283 58.349 µM -0.319759180341271 0.395429996083003 no 2070 0.37457544679489 3159 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_733 4069-0007 56.1 µM -0.321939851276721 0.394615812687924 no 2071 0.373749131048406 3000 5717425 YNL287W SEC21 SGTC_1328 1441-0025 69.2 µM -0.321959911357277 0.394608325112142 no 2072 0.373741532422706 2940 4562601 SGTC_129 0088-0017 176.636 µM -0.322411822302467 0.394439656279824 no 2073 0.373570364559823 3104 182446 SGTC_2726 cimetidine 79.27 µM -0.322865395924947 0.394270386777524 no 2074 0.373398592009081 2965 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2591 skatole 100 µM -0.325373960399997 0.393334574996875 no 2075 0.372449030417553 3094 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2659 sanguinarine 24.21 µM -0.327278748427579 0.392624411121301 no 2076 0.371728532232314 2968 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1370 2001-0092 44.6 µM -0.327335538129058 0.392603243638813 no 2077 0.371707058048068 3203 790957 SGTC_2008 4012253 172 µM -0.328077041346724 0.392326888963364 no 2078 0.371426706248613 2951 603940 SGTC_669 0108-0021 26.2 µM -0.328696475193957 0.392096070568657 no 2079 0.371192559410404 3252 17201 SGTC_2875 9039966 71.43 µM -0.329084009975827 0.391951683559133 no 2080 0.371046094970229 3062 6463691 SGTC_3068 9116768 49.47 µM -0.329582633432738 0.391765929221364 no 2081 0.370857673285543 3089 41904888 SGTC_1286 0929-0070 131 µM -0.329925837849116 0.391638088138493 no 2082 0.370727999912956 3087 1420408 SGTC_633 0437-0093 97.7 µM -0.329938273087641 0.391633456324566 no 2083 0.3707233017661 2996 2831118 SGTC_2119 5528445 120.635 µM -0.331314249493882 0.391121034719257 no 2084 0.370203564510638 3134 791935 SGTC_1094 duloxetine 25.4 µM -0.334578556169644 0.389906145270249 no 2085 0.368971511603654 2981 60834 A selective serotonin reuptake inhibitor. SGTC_1618 st003135 44.5 µM -0.334604183086662 0.389896611839376 no 2086 0.368961844497355 3068 1270615 SGTC_2342 7990637 118.86 µM -0.334717216302684 0.389854563313028 no 2087 0.368919206564615 3107 2033102 YER133W GLC7 SGTC_1267 0828-0272 9.49 µM -0.334825195999833 0.389814395907145 no 2088 0.368878476406396 3122 745334 SGTC_150 3970-0969 77.2 µM -0.335113130028906 0.389707292979034 no 2089 0.368769874313185 3106 6615640 SGTC_1852 st056254 31.4 µM -0.335376851050867 0.389609203920106 no 2090 0.368670414003017 2990 442583 SGTC_1305 1181-0477 144 µM -0.336458887838179 0.389206822115091 no 2091 0.368262424488565 3135 6252086 SGTC_1777 st045864 34.765 µM -0.337652370063543 0.388763134376849 no 2092 0.367812585948517 3068 4691462 SGTC_903 1134-0042 114 µM -0.338327657801908 0.388512154314039 no 2093 0.367558141711421 3023 701009 SGTC_749 1000-0129 128 µM -0.338454563898954 0.388464993092843 no 2094 0.367510330765192 3172 708470 SGTC_2880 9042983 58.44 µM -0.338743316726328 0.388357692036104 no 2095 0.367401552897031 3127 6464714 SGTC_1287 0971-0001 34.6 µM -0.33993469536213 0.387915063828176 no 2096 0.366952853859943 3033 4665869 SGTC_1574 spiramycin 23.7 µM -0.340455899239825 0.387721468750132 no 2097 0.36675661426776 2951 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2963 9082507 9 µM -0.3408088043041 0.387590402138715 no 2098 0.366623760990112 3168 16459611 SGTC_829 1635-0120 117 µM -0.341542468241022 0.387317965205372 no 2099 0.366347619850131 3141 285054 SGTC_2703 st077852 53.4 µM -0.34180364461314 0.387220994009256 no 2100 0.366249333303263 3120 6281836 SGTC_1926 methyl fluorone black 53.6 µM -0.34334618807633 0.38664841254066 no 2101 0.365669018613405 3032 72721 Reacts with homocysteine. SGTC_1275 0867-0008 21.1 µM -0.34349975761777 0.386591422069616 no 2102 0.365611261570333 2979 3422836 SGTC_910 3454-3003 490 µM -0.343592993239651 0.386556823029165 no 2103 0.365576197419382 3142 820824 SGTC_1741 st038134 10.228 µM -0.344528155524953 0.386209841241632 no 2104 0.365224562781267 3242 1272587 SGTC_850 0388-0143 75.9 µM -0.345642358047288 0.385796547325633 no 2105 0.364805754310366 3014 67273 SGTC_567 1080-0542 68.4 µM -0.34604859699965 0.385645892316457 no 2106 0.364653096565702 3077 5950415 SGTC_2223 6903751 107.57 µM -0.346683825253651 0.385410350478557 no 2107 0.36441443152506 3093 5598863 SGTC_1830 st055982 50.3 µM -0.347056888005612 0.385272038970737 no 2108 0.364274290592017 3137 455313 An antimicrobial agent. SGTC_307 1501-1223 22.3 µM -0.350768576455642 0.383896742964602 no 2109 0.362880986743618 3108 2830329 SGTC_2135 5326629 150.42 µM -0.350782318961508 0.383891653642873 no 2110 0.362875831401884 3063 5020077 SGTC_1910 st062352 60.4 µM -0.352373912237204 0.383302367681929 no 2111 0.362278931970665 2955 2245730 SGTC_9 0092-0002 10.449 µM -0.355339416430007 0.382205113313972 no 2112 0.361167664818261 3097 759368 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.355340025865102 0.382204887916184 no 2113 0.361167436563869 3139 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_577 r071-0003 38.6 µM -0.356718225298917 0.381695267139972 no 2114 0.36065138009429 3029 4568517 YMR134W ERG29 SGTC_3134 9127454 49.47 µM -0.357935801624294 0.381245210939714 no 2115 0.36019567874514 3153 24262820 SGTC_891 0929-0073 133 µM -0.358811860689655 0.380921490019976 no 2116 0.359867919591044 3163 5603632 SGTC_1426 4048-4480 71.7 µM -0.358978972049397 0.380859748568765 no 2117 0.359805410067563 3153 14224343 SGTC_1546 5-methoxyflavanone 78.7 µM -0.359153276553748 0.380795352749575 no 2118 0.359740213878349 3098 147795 SGTC_499 genistein 192 µM -0.359890757698506 0.380522931046979 no 2119 0.359464414440219 3108 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1630 st005209 31.3 µM -0.36021538543983 0.380403034015119 no 2120 0.359343035004643 3144 3367314 SGTC_2358 9037157 4 µM -0.360555570306598 0.380277403489206 no 2121 0.359215853935556 3129 2388925 SGTC_2434 5670830 169.91 µM -0.360580452937207 0.380268214810581 no 2122 0.359206551959884 3130 1549830 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.36142698298558 0.379955647770809 no 2123 0.358890139917193 3076 688788 SGTC_2338 7999974 200 µM -0.361686891645019 0.379859696573335 no 2124 0.358793011886298 3074 315925 SGTC_2555 cholic acid 100 µM -0.362877698143002 0.379420177899448 no 2125 0.35834812357233 3201 6708657 Influences liver metabolism. SGTC_3173 9105693 49.47 µM -0.363289816086211 0.379268104194578 no 2126 0.358194200009857 3211 17096658 SGTC_2095 5432005 200 µM -0.363321725871041 0.379256330093777 no 2127 0.358182282858864 3038 783734 SGTC_1620 st003704 16.5 µM -0.363400500058115 0.379227264403677 no 2128 0.358152864139483 3175 2834414 SGTC_1602 st001878 87.6 µM -0.365860643224567 0.3783198779384 no 2129 0.35723453272242 3199 595405 YLR310C CDC25 SGTC_6 0844-0013 19.835 µM -0.367298817629099 0.377789739411558 no 2130 0.356698067972328 3140 1584900 SGTC_2203 7227154 166.4 µM -0.367861859926763 0.377582253897579 no 2131 0.356488120250295 3096 896304 SGTC_1507 4075-3230 155 µM -0.371014562302232 0.37642111246914 no 2132 0.355313342718196 3115 659771 SGTC_2131 toluylene red 5.2905 µM -0.37150885578505 0.376239165063567 no 2133 0.355129280606305 3049 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2247 cerulenin 830 nM -0.371585226351971 0.376211055822582 no 2134 0.35510084519524 3282 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3276 9139060 49.47 µM -0.371770579605459 0.37614283673094 no 2135 0.355031835105886 3017 4870619 SGTC_76 0433-0009 400.328 µM -0.371918802111438 0.376088286360699 no 2136 0.354976652831116 3137 2841569 SGTC_913 3487-1245 167 µM -0.372545555895429 0.375857649369058 no 2137 0.354743350113009 3005 4016153 SGTC_1119 parthenolide 318.541 nM -0.373386517978292 0.375548256271179 no 2138 0.35443039612322 3248 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1027 k015-0025 8.67 µM -0.3747589848728 0.375043492499947 no 2139 0.35391986007936 3022 3598955 SGTC_1029 k015-0030 64.7 µM -0.375664485918652 0.374710585790734 no 2140 0.35358317165477 3175 2208316 SGTC_2969 9091408 28.7 µM -0.376448541215226 0.374422403910088 no 2141 0.353291732356961 3022 4286311 SGTC_3138 9097216 49.47 µM -0.377265769825416 0.37412210373158 no 2142 0.352988053832229 3102 25237486 SGTC_2302 7771753 200 µM -0.378145181367391 0.373799039018684 no 2143 0.352661372979913 3126 2203047 SGTC_1484 3473-2379 286 µM -0.37854838219235 0.373650946913434 no 2144 0.352511629592257 3156 671917 SGTC_276 colchicine 750 µM -0.379351870850356 0.373355888263956 no 2145 0.352213292832755 3209 2833 A microtubule depolymerizer. SGTC_806 3966-4455 5.86 µM -0.379711357843716 0.373223900787022 no 2146 0.352079844105876 3081 714982 SGTC_2197 6588183 93.1375 µM -0.381757149510525 0.37247306159556 no 2147 0.351320752738766 3068 884136 SGTC_2781 5567276 71.43 µM -0.382136535703877 0.372333873785495 no 2148 0.351180046481929 3233 2853274 SGTC_2761 levamisole 97.89 µM -0.3828250456215 0.372081318403029 no 2149 0.350924744932045 3229 26879 An alkaline phosphatase inhibitor. SGTC_784 4579-0127 173 µM -0.383374072120556 0.371879966977156 no 2150 0.350721212466443 3271 1948547 SGTC_644 1498-1197 63.3 µM -0.385452709830884 0.37111795975823 no 2151 0.349951018415774 3181 6741615 SGTC_1888 azatryptophan 97.5 µM -0.385867752493739 0.370965869775858 no 2152 0.349797307161417 3174 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2788 5282734 71.43 µM -0.387518409882331 0.370361195611249 no 2153 0.349186229225579 3237 743706 SGTC_1670 st016595 4.04 µM -0.387665914046945 0.370307176970555 no 2154 0.349131641773875 3161 597879 SGTC_1311 1190-0148 100 µM -0.388212968120806 0.370106858408171 no 2155 0.34892921856401 3220 1961333 SGTC_2347 9049783 174.81 µM -0.38822548024403 0.370102277169638 no 2156 0.348924589279068 3238 6467988 YPL169C MEX67 SGTC_114 0364-0001 490.298 µM -0.389273516575361 0.369718610463711 no 2157 0.348536912529286 3147 4003655 SGTC_2314 7727897 200 µM -0.390276090131088 0.369351708175461 no 2158 0.348166200795985 3067 900724 SGTC_3337 9144342 33.5465 µM -0.390474160706227 0.369279236237735 no 2159 0.348092979339205 3184 17682949 SGTC_3160 9100216 49.47 µM -0.391113380082503 0.369045384298394 no 2160 0.347856715469075 3138 17191039 SGTC_2656 pseudo-anisatin 100 µM -0.391301226796468 0.368976671689082 no 2161 0.347787296082954 3108 6708809 A neurotoxin. SGTC_2719 novobiocin 32.65 µM -0.391459543010699 0.368918764317868 no 2162 0.347728793754742 3213 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1468 k284-1086 134 µM -0.391577667733825 0.368875559739095 no 2163 0.347685145683299 3121 15996457 SGTC_1721 st082152 9.2685 µM -0.391806529287034 0.368791857447704 no 2164 0.347600585173996 3070 5296051 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.392434914965651 0.368562067892315 no 2165 0.347368446195303 3055 15053 SGTC_3057 9095946 49.47 µM -0.393810173643642 0.368059324130064 no 2166 0.346860596334344 3083 24540043 SGTC_2337 9009472 200 µM -0.393925444925378 0.368017195457097 no 2167 0.346818041908586 3294 5742383 SGTC_3123 9126162 49.47 µM -0.394130309932768 0.367942326511766 no 2168 0.346742417148577 3069 25239884 SGTC_2143 5623677 140.463 µM -0.394352225737216 0.367861231927252 no 2169 0.346660505072657 3181 5375313 SGTC_3299 9121982 43.1275 µM -0.394927106560596 0.36765118090636 no 2170 0.346448342257116 3108 17594604 YPL160W CDC60 SGTC_578 3460-0051 92 µM -0.395131955704775 0.367576342308458 no 2171 0.346372753230181 3235 2876744 SGTC_3048 9093155 49.47 µM -0.396548144328687 0.367059096478241 no 2172 0.345850349249415 3225 25236002 SGTC_1712 st032288 53.4 µM -0.396869238273821 0.366941854295622 no 2173 0.345731944798423 3196 2883011 SGTC_3297 9117502 71.43 µM -0.397383146490163 0.366754234975334 no 2174 0.345542470851224 3194 7453720 SGTC_2814 7977482 42.97 µM -0.397849642085777 0.366583952770087 no 2175 0.34537051106653 3251 6456762 SGTC_1652 st011932 78 µM -0.398377022750164 0.366391477660869 no 2176 0.345176146237423 3199 1551076 SGTC_2404 5161160 200 µM -0.399330038287848 0.36604374627915 no 2177 0.344825018327415 3071 2831543 SGTC_1552 6-methylflavone 10.6 µM -0.399351268718655 0.366036001080803 no 2178 0.344817197733062 3211 689013 SGTC_2478 5763493 32.33 µM -0.400814645047985 0.365502269871508 no 2179 0.344278297851665 3082 1365576 YLR208W SEC13 SGTC_2851 9015922 71.43 µM -0.400826684405005 0.365497879884793 no 2180 0.344273865572664 3271 2996893 SGTC_1573 oleylamine 1.06 µM -0.401112509848933 0.365393662725431 no 2181 0.344168645462468 3100 5356789 An amine of the fatty acid oleic acid. SGTC_1491 4138-0063 26.5 µM -0.401410075296058 0.365285175505833 no 2182 0.344059116354253 3195 23883227 SGTC_1590 st077108 57.8 µM -0.402155910238984 0.365013304359404 no 2183 0.343784643879908 3208 5489485 SGTC_1170 0310-0127 64.8 µM -0.403385837240964 0.364565120611707 no 2184 0.343332201994776 3159 774975 SGTC_1259 0671-0132 43 µM -0.403563425125196 0.364500423100657 no 2185 0.343266892907699 3106 X1259 SGTC_2004 4023728 41.89 µM -0.40494633814131 0.363996742592905 no 2186 0.342758478016054 3265 360084 YDR527W RBA50 SGTC_3016 9080866 49.47 µM -0.404953233596487 0.363994231738277 no 2187 0.342755943679656 3115 17066299 SGTC_2943 9068529 45.32 µM -0.406862824782132 0.363299113887873 no 2188 0.342054370554664 3149 3270634 SGTC_793 0488-0545 106 µM -0.409332085781234 0.36240093571965 no 2189 0.341147985987765 3091 292548 SGTC_319 1348-1596 45.5 µM -0.409380658410567 0.362383275305853 no 2190 0.341130165739801 3291 5380505 SGTC_2468 5987765 72.9 µM -0.409672978448557 0.362276997502277 no 2191 0.341022927319912 3148 26772094 SGTC_2113 5491891 107.031 µM -0.409888023384347 0.362198821121319 no 2192 0.340944045684287 3158 789979 SGTC_3230 9131665 49.47 µM -0.411972271205679 0.36144142214149 no 2193 0.340179873729641 3121 15943720 SGTC_455 paf C-16 10 µM -0.412488152492547 0.36125403867737 no 2194 0.339990831342857 3124 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3080 9117754 49.47 µM -0.412626810193532 0.36120367973971 no 2195 0.339940027706108 3329 9550191 SGTC_2724 maprotiline 69.64 µM -0.412717042492216 0.361170909662392 no 2196 0.339906968507597 3258 4011 A tricyclic antidepressant. SGTC_429 1112-0049 25.5 µM -0.414506591655702 0.360521201642013 no 2197 0.339251570306374 3074 2836170 SGTC_2298 7976326 193.81 µM -0.414508318444407 0.360520574913677 no 2198 0.339250938127759 3142 2235818 SGTC_1177 0983-0204 23.6 µM -0.416571266938071 0.359772107309386 no 2199 0.338496014788658 3272 766818 SGTC_1385 3091-4834 14.1 µM -0.41855340351326 0.359053465642888 no 2200 0.337771274911739 3234 4072814 SGTC_2888 9058547 12.99 µM -0.41856445451927 0.359049460395075 no 2201 0.3377672359521 3110 16476514 SGTC_1439 4092-1168 46 µM -0.419061918200896 0.35886917925849 no 2202 0.337585440572272 3207 2886240 SGTC_504 lovastatin 124 µM -0.420278475918565 0.358428430512048 no 2203 0.337141015939452 3171 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_668 1682-0499 62.6 µM -0.421186691405661 0.358099514463813 no 2204 0.3368093808766 3197 682214 SGTC_3331 9141060 1.957 µM -0.422584166073776 0.357593615793852 no 2205 0.33629934053656 3121 4906567 YPR165W RHO1 SGTC_2813 7971799 71.43 µM -0.424578832369348 0.356871961691653 no 2206 0.335571863282644 3228 2234054 SGTC_807 1315-0151 48 µM -0.427604969590991 0.35577810781698 no 2207 0.334469373608609 3352 4011080 SGTC_2235 salicylic acid 500 µM -0.429608618402642 0.355054503699853 no 2208 0.33374018338079 3218 338 A COX inhibitor and kinase inhibitor. SGTC_2163 5671233 125 µM -0.430972736077742 0.354562160638431 no 2209 0.33324409729243 3358 701023 SGTC_1401 3807-4679 7.6 µM -0.430990232697216 0.354555847261251 no 2210 0.333237736222213 3217 3291456 SGTC_3265 9137266 49.47 µM -0.431549643000721 0.354354014010491 no 2211 0.333034382329319 3225 17224265 SGTC_1563 conessine 56.1 µM -0.433122143836728 0.353786880517771 no 2212 0.332463018182931 3247 441082 An anti-amoebic, histamine inhibitor. SGTC_2627 acetyl isogambogic acid 100 µM -0.434002675635471 0.353469452090351 no 2213 0.332143249042048 3253 6857789 A caspase activator and apoptosis inducer. SGTC_3015 9080845 49.47 µM -0.43525418254242 0.353018463875601 no 2214 0.331688968878532 3294 5296973 SGTC_1025 k007-0731 70 µM -0.437023000934558 0.352381411389899 no 2215 0.331047333655873 3133 6256118 SGTC_1529 apigenin 74 µM -0.437252731968205 0.352298702461566 no 2216 0.330964035541398 3383 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_728 3030-5151 22.5 µM -0.438765697838263 0.351754171475945 no 2217 0.330415658814123 3173 3125388 SGTC_2087 5276107 200 µM -0.440057074685643 0.351289632909826 no 2218 0.329947885185554 3153 144405 SGTC_1348 1493-0373 93.8 µM -0.441093459913319 0.350916981402985 no 2219 0.329572669004477 3214 3010129 SGTC_1502 4534-4282 27.7 µM -0.441594839084009 0.350736752662132 no 2220 0.3293912096345 3210 3278949 SGTC_687 k029-0044 34.9 µM -0.441701856841832 0.350698287770029 no 2221 0.32935248292165 3284 5829338 SGTC_3156 9099931 49.47 µM -0.441860624084815 0.350641225622131 no 2222 0.329295032899903 3124 18111053 SGTC_171 k064-0041 9.68 µM -0.442712313942595 0.35033517939549 no 2223 0.328986917241736 3178 53325 SGTC_801 0866-0028 10.1 µM -0.443035768427051 0.350218974706357 no 2224 0.328869931605276 3139 6849771 SGTC_1607 st000305 50.6 µM -0.444341642435902 0.349749967342193 no 2225 0.328397799226284 3299 5457690 SGTC_916 4466-0038 42 nM -0.4448669589687 0.349561363420793 no 2226 0.328207950805959 3385 5722064 YGL116W CDC20 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.445138882758951 0.349463749448362 no 2227 0.328109695474974 3401 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2294 7971431 200 µM -0.445355342213467 0.349386052927738 no 2228 0.328031489799408 3272 5741572 SGTC_2149 5554786 194.827 µM -0.445474561296322 0.349343262814249 no 2229 0.327988419783881 3198 745063 YPR165W RHO1 SGTC_1413 3910-0535 34.4 µM -0.445563140924219 0.349311471053819 no 2230 0.327956420297857 3302 2876951 SGTC_588 3970-1144 52.9 µM -0.446597925654899 0.348940158966598 no 2231 0.327582696803399 3260 1888707 SGTC_2153 5569715 200 µM -0.448978628537343 0.348086440239898 no 2232 0.326723536810679 3242 2054701 SGTC_3200 9114385 49.47 µM -0.449695809451884 0.347829410154383 no 2233 0.326464896686947 3313 17018030 YLR208W SEC13 SGTC_2480 5767542 37.17 µM -0.450443465707894 0.347561532460755 no 2234 0.326195354900402 3193 2867358 SGTC_42 0133-0086 60.653 µM -0.450722824672495 0.347461460485038 no 2235 0.32609466490491 3151 162923 Model of phenazepam hydroxylation. SGTC_518 1021-0119 62.6 µM -0.454180689128892 0.346223666289816 no 2236 0.324849390434469 3202 1097762 SGTC_1816 st051957 91.6 µM -0.454382997508951 0.346151297668616 no 2237 0.324776593879218 3227 674121 SGTC_1814 st052110 31.539 µM -0.454416027061488 0.346139483055378 no 2238 0.324764709501979 3326 674163 SGTC_3232 9132874 49.47 µM -0.454467414049547 0.346121102317254 no 2239 0.324746220282751 3245 3784940 SGTC_2208 7283366 200 µM -0.456493451575118 0.345396693270185 no 2240 0.324017589359605 3304 898663 SGTC_3305 9127027 53.8275 µM -0.458685495057315 0.344613566240771 no 2241 0.323230015835644 3192 41905295 SGTC_3081 9117243 49.47 µM -0.459678300641548 0.34425909636164 no 2242 0.322873573567755 3354 45595589 SGTC_1508 1080-0625 72.9 µM -0.460309783711547 0.344033703697358 no 2243 0.322646939806842 3280 767111 SGTC_1616 st002734 56.1 µM -0.462973270840626 0.343083646630161 no 2244 0.321691763174837 3188 4026101 SGTC_1436 4092-1007 8.32 µM -0.463921542036731 0.34274564034773 no 2245 0.321351979140965 3219 2881121 SGTC_1638 st008370 60.6 µM -0.464908178368313 0.342394092600266 no 2246 0.320998606773267 3292 24207134 SGTC_2821 7996764 71.43 µM -0.465087370312279 0.34233025947453 no 2247 0.320934445003639 3435 2987135 SGTC_2864 9034755 47.6 µM -0.465522179045327 0.342175387307503 no 2248 0.320778778887221 3325 4930451 SGTC_1077 5-fluorocytosine 377 nM -0.468717015745104 0.341038251236292 no 2249 0.319635961334666 3291 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_661 1304-0007 33.6 µM -0.469076281016082 0.340910468223903 no 2250 0.319507556189586 3258 3117130 SGTC_343 4130-2827 29.8 µM -0.469349229388932 0.340813398493679 no 2251 0.319410016065112 3259 1118244 SGTC_2161 5662504 8.5105 µM -0.469887000972735 0.340622179459979 no 2252 0.319217875968667 3229 2859334 SGTC_2492 derrusnin 100 µM -0.471477500550459 0.340056874744896 no 2253 0.318649891576455 3261 1715307 Part of coumarin class of compounds. SGTC_1075 aripiprazole 15.2 µM -0.473058120101315 0.33949543765143 no 2254 0.318085857249221 3239 60795 An atypical antipschotic. YIL048W NEO1 SGTC_441 propafenone 146 µM -0.473101247979201 0.339480123585367 no 2255 0.318070473235815 3220 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2074 5212007 75.395 µM -0.474567038265883 0.338959801056017 no 2256 0.317547802435689 3323 758611 SGTC_989 1501-0895 10.3 µM -0.474579718635976 0.338955301148633 no 2257 0.317543282459813 3356 2830112 SGTC_1086 cerivastatin 2.18 µM -0.477191305289016 0.338029012895945 no 2258 0.316612950968064 3311 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_923 1900-2434 73.3 µM -0.478111184321727 0.337702979473369 no 2259 0.316285536040239 3271 5910570 SGTC_2693 st077581 40.7 µM -0.479621351906391 0.337167993741203 no 2260 0.315748330461702 3351 25238761 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.479972914095753 0.33704349795962 no 2261 0.315623326498846 3282 6312947 SGTC_2255 7941087 197.44 µM -0.480243766670261 0.336947595370355 no 2262 0.315527034606605 3362 935561 SGTC_2975 9084847 53.72 µM -0.48142686774759 0.336528811156946 no 2263 0.315106572473757 3298 27211724 SGTC_979 1426-2828 121 µM -0.482310280347428 0.336216240301868 no 2264 0.314792772692741 3375 747872 SGTC_2521 angolensin 13.4 µM -0.482376975135174 0.33619264680833 no 2265 0.314769087251064 3360 821428 A flavenoid. SGTC_292 k038-0015 474 µM -0.48320613630331 0.33589938230358 no 2266 0.314474689381398 3349 46368540 SGTC_776 4476-4378 112 µM -0.483208521989591 0.335898538658568 no 2267 0.314473842501476 3335 2892008 SGTC_852 0418-0143 439 µM -0.4846134835981 0.335401848917449 no 2268 0.31397527363314 3358 5369229 SGTC_2756 carbadox 75.1 µM -0.486476005082608 0.33474384345446 no 2269 0.313314856937753 3262 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1789 tunicamycin 25 nM -0.487510243819038 0.334378678733575 no 2270 0.312948392605794 3366 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3114 9122766 49.47 µM -0.488427558284333 0.334054928225173 no 2271 0.312623512906527 3300 17176985 SGTC_2866 9034245 58.44 µM -0.48995009221058 0.333517848395445 no 2272 0.312084607626577 3288 6462273 SGTC_1958 st076513 41.9 µM -0.490129402242507 0.333454618503863 no 2273 0.312021166754838 3232 732122 YGL099W LSG1 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.491987623777667 0.332799634837379 no 2274 0.311364046346631 3351 364106 SGTC_2305 7443522 69.23 µM -0.492039154181615 0.33278147872087 no 2275 0.311345832267373 3307 5415886 SGTC_1407 3909-7909 12.3 µM -0.49322919310877 0.332362292023685 no 2276 0.31092532636955 3324 4411780 SGTC_483 fpl-64176 144 µM -0.494035557982557 0.332078372150417 no 2277 0.3106405337336 3363 3423 SGTC_336 4111-0029 111 µM -0.494494082118669 0.331916969454285 no 2278 0.310478642366671 3293 3131175 SGTC_2090 5301565 104.445 µM -0.494532307166053 0.331903515462119 no 2279 0.310465147885384 3285 2056344 SGTC_2699 st077704 54.6 µM -0.494750737689715 0.331826639073687 no 2280 0.310388040864236 3330 645852 SGTC_7 0192-1582 4.227 µM -0.495401471827502 0.331597655870749 no 2281 0.31015837799515 3332 252616 SGTC_2211 7117706 200 µM -0.495584277053362 0.331533340876863 no 2282 0.310093874067361 3342 822771 SGTC_2564 betulinic acid 100 µM -0.49590280865445 0.331421286156701 no 2283 0.309981492231466 3475 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1991 st073000 8.92 µM -0.499949958925166 0.329998875061478 no 2284 0.308555156673747 3457 4301969 YIL048W NEO1 SGTC_3191 9110352 49.47 µM -0.501458833376312 0.329469193104661 no 2285 0.308024121529102 3358 17122424 SGTC_2083 5306046 65.942 µM -0.501786787066601 0.32935411199781 no 2286 0.307908754206012 3316 539837 SGTC_1154 4088-0362 150 µM -0.502197997258775 0.329209838476939 no 2287 0.307764125793492 3344 6618304 SGTC_2324 6149169 200 µM -0.502246485382394 0.329192828044383 no 2288 0.307747073805904 3277 2888231 SGTC_1464 k208-0027 110 µM -0.502276713395954 0.329182223738186 no 2289 0.307736443625054 3443 X1464 SGTC_2610 ononetin 44.17 µM -0.502690562435848 0.329037054951406 no 2290 0.307590923000268 3337 259632 SGTC_2433 5607874 27.82 µM -0.50349024697069 0.328756616941426 no 2291 0.307309817853342 3299 2252428 SGTC_1432 4049-0298 68.4 µM -0.505943989947402 0.32789672635944 no 2292 0.306447984886158 3372 741646 SGTC_1843 st055809 45.5 µM -0.506367371061625 0.327748448618621 no 2293 0.306299387962865 3366 16413835 SGTC_2293 7624732 200 µM -0.507374864846567 0.327395710505482 no 2294 0.305945909204066 3329 894453 SGTC_2187 6125751 200 µM -0.507717966532658 0.327275620802037 no 2295 0.305825573346643 3336 874498 SGTC_2079 5212404 121 µM -0.508323721247619 0.327063643035443 no 2296 0.305613168520752 3418 758462 SGTC_227 fluconazole 33.516 µM -0.509252829349995 0.326738619410493 no 2297 0.305287508556723 3330 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2176 5809774 33.9695 µM -0.510465245431882 0.326314685751176 no 2298 0.304862778540098 3352 2870539 SGTC_1509 1326-1131 80 µM -0.511665518612077 0.3258952188919 no 2299 0.304442561235185 3366 768313 SGTC_1711 st032263 62.8 µM -0.51370248935923 0.325183850493203 no 2300 0.303730005630504 3343 3958979 SGTC_1908 st060353 56.5 µM -0.514185050519068 0.32501541952676 no 2301 0.303561309335173 3465 4227716 SGTC_1655 st012546 55.1 µM -0.515581121717582 0.324528342596024 no 2302 0.30307349913567 3361 720985 YLR208W SEC13 SGTC_297 0986-0032 24 µM -0.516520299920492 0.324200840332677 no 2303 0.30274553229347 3306 2847425 SGTC_234 nsc-17383 10.7 µM -0.516637348097198 0.324160033808765 no 2304 0.30270466948821 3440 408974 SGTC_3070 9117005 49.47 µM -0.516899270284325 0.32406872748885 no 2305 0.302613238525102 3408 8779016 SGTC_718 1130-0073 349 µM -0.516995168098988 0.32403530006697 no 2306 0.302579765916631 3473 6740020 SGTC_2798 7813637 45.45 µM -0.517171369633527 0.323973884607377 no 2307 0.302518268059248 3400 956368 SGTC_3229 9132204 49.47 µM -0.517796816068126 0.32375592247682 no 2308 0.302300020011033 3327 17682924 SGTC_1803 st050068 52.4 µM -0.517861430696364 0.323733408336674 no 2309 0.302277476916394 3459 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2376 9072922 81.32 µM -0.520984679259357 0.322645922789629 no 2310 0.301188722091007 3428 17087968 SGTC_1187 1391-0724 117 µM -0.521718025455539 0.322390797921277 no 2311 0.300933336193461 3379 6997986 SGTC_400 oxethazaine 37.5 µM -0.522321457981287 0.322180931617792 no 2312 0.300723265653313 3374 4621 A local anesthetic. SGTC_658 3253-0951 102 µM -0.524280681877913 0.321499929024756 no 2313 0.300041665603595 3364 1184878 SGTC_1714 st033236 13.627 µM -0.524859288234105 0.321298926995192 no 2314 0.299840506330039 3483 2916566 SGTC_132 0417-1715 25.805 µM -0.525159664881705 0.321194599798977 no 2315 0.299736100954076 3461 6769098 SGTC_695 3505-6186 243 µM -0.525674652643273 0.321015766435331 no 2316 0.299557139042292 3402 1819379 SGTC_2226 7298446 200 µM -0.525777485900527 0.320980061785884 no 2317 0.29952140955468 3399 3283010 SGTC_472 calcifediol 10 µM -0.526483951338936 0.320734815274075 no 2318 0.299275999877283 3388 5283731 A vitamin D metabolite. SGTC_2179 6298986 200 µM -0.52677801423058 0.320632755624643 no 2319 0.299173876156226 3415 738374 SGTC_1220 1838-0075 193 µM -0.526856467224262 0.320605529437292 no 2320 0.299146633257147 3362 5529645 SGTC_628 1636-0253 16 µM -0.532248206862362 0.318736708845308 no 2321 0.297277049451831 3379 4456143 SGTC_1090 efavirenz 20.7 µM -0.533383735936703 0.318343710160583 no 2322 0.296883986821167 3401 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2729 fluphenazine 10.66 µM -0.535978448428803 0.317446465782893 no 2323 0.295986722646559 3319 3372 An atypical antipsychotic. SGTC_2044 5102272 200 µM -0.536011193705203 0.317435149393213 no 2324 0.295975407129643 3423 592666 SGTC_1037 k284-1091 78.7 µM -0.537256012572608 0.317005080974156 no 2325 0.295545392633921 3431 3334711 SGTC_2836 9010338 19.48 µM -0.53889245031876 0.316440089392253 no 2326 0.294980533431623 3313 2994051 SGTC_1725 st036284 20.55 µM -0.539988216529666 0.316062007665697 no 2327 0.294602579381316 3484 707914 SGTC_864 0469-0573 172 µM -0.540238731886488 0.315975597168906 no 2328 0.294516202470363 3352 689425 SGTC_2930 9013230 14.89 µM -0.540710886906469 0.315812763628375 no 2329 0.294353436677449 3439 2995857 SGTC_2452 5863136 48.41 µM -0.541050733510066 0.315695581812368 no 2330 0.294236307221072 3375 2184096 SGTC_1306 1185-0270 9.02 µM -0.54125952589293 0.315623597721741 no 2331 0.294164356791545 3422 1548076 SGTC_1261 0712-0010 12.7 µM -0.541343584047542 0.31559461947342 no 2332 0.294135392415692 3484 2840123 SGTC_348 k064-0012 10.7 µM -0.542355079795547 0.315246004900737 no 2333 0.293786959213194 3363 5066323 SGTC_1703 st026983 48.3 µM -0.542391399319566 0.315233490341408 no 2334 0.293774451662096 3468 1104023 SGTC_1837 st055472 66.5 µM -0.543237593254888 0.314941978712839 no 2335 0.293483113043527 3507 676091 SGTC_863 0466-0191 129 µM -0.544636319038944 0.314460374036961 no 2336 0.293001835243521 3426 765160 YPR165W RHO1 SGTC_3094 9117742 49.47 µM -0.544948353892171 0.31435297824434 no 2337 0.292894519323312 3401 17149698 SGTC_3201 9113999 49.47 µM -0.545237696409457 0.314253406712385 no 2338 0.292795024120648 3438 16649224 SGTC_1522 st012842 45.6 µM -0.545459518456578 0.314177080173302 no 2339 0.292718757574971 3378 3491067 YOR116C RPO31 SGTC_29 0299-0004 12.984 µM -0.547017946977558 0.313641066145921 no 2340 0.292183201149836 3353 16871 A napthoquinone isolated from Swertia calycina. SGTC_3086 9117350 49.47 µM -0.547611165215335 0.313437134832367 no 2341 0.291979460634733 3397 2679265 SGTC_1430 4049-0248 69.1 µM -0.548492416569318 0.313134291324526 no 2342 0.291676917472619 3465 22774488 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.54905877975107 0.312939726163907 no 2343 0.291482556004098 3331 803109 SGTC_392 N-ethylmaleimide 8.33 µM -0.551026822234899 0.312264041379463 no 2344 0.290807643892425 3358 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1927 st060202 13.8 µM -0.553527214114112 0.311406496022116 no 2345 0.289951225456596 3472 688887 SGTC_2838 9002687 71.43 µM -0.554718943827956 0.310998134589952 no 2346 0.289543458305151 3362 6457060 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.555005521934783 0.310899969609869 no 2347 0.289445441735851 3392 688761 SGTC_813 k007-0158 173 µM -0.555027047405488 0.31089259677964 no 2348 0.289438080139192 3415 6523916 SGTC_285 1486-1325 46 µM -0.555663037240676 0.310674793995209 no 2349 0.289220614691238 3468 22310230 SGTC_188 3229-0966 278.469 µM -0.55706915728257 0.310193485899236 no 2350 0.288740089699091 3487 5722370 SGTC_2586 curcumin 80 µM -0.557831644099359 0.309932626172929 no 2351 0.288479676083975 3438 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1879 gemcitabine 100 µM -0.560040712507663 0.309177406627302 no 2352 0.287725834178027 3421 60750 A nucleoside analog which inhibits DNA replication. SGTC_1514 1189-1591 158 µM -0.560432332540289 0.309043606521915 no 2353 0.287592291508725 3506 767698 YMR146C TIF34 SGTC_2508 celastrol 40.54 µM -0.560826237332522 0.308909051361196 no 2354 0.287457999298263 3410 122724 Celastrol is a natural product and antioxidant. SGTC_3187 9109394 49.47 µM -0.5618941210488 0.308544398667631 no 2355 0.287094079706107 3385 17098090 SGTC_2033 5192550 145 µM -0.563955933756804 0.307840881016465 no 2356 0.286392061117796 3386 182073 SGTC_2217 6934799 96.0675 µM -0.565215638911862 0.307411400176703 no 2357 0.285963550363473 3444 675606 SGTC_315 k915-0449 187 µM -0.567095181239443 0.306771084312113 no 2358 0.285324758310305 3453 20970215 YNL149C PGA2 SGTC_313 3474-0040 5.03 µM -0.568634689490956 0.306247048849776 no 2359 0.284802039101263 3428 1043375 YIL048W NEO1 SGTC_2470 5664817 21.68 µM -0.568896989928697 0.306157803488023 no 2360 0.284713024115905 3485 2859561 SGTC_232 clozapine 119 µM -0.570092823620203 0.305751077663459 no 2361 0.284307371132666 3435 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3078 9116413 49.47 µM -0.571906864523746 0.305134545100933 no 2362 0.283692536622366 3395 17177322 SGTC_2653 dihydrofissinolide 100 µM -0.572200139090984 0.305034922610167 no 2363 0.283593196641239 3476 6857746 SGTC_759 3486-0358 89.3 µM -0.572352666246514 0.304983116343249 no 2364 0.283541538181346 3523 875103 SGTC_709 3807-1509 243 µM -0.572374755846803 0.304975613873881 no 2365 0.283534057167823 3495 1886677 YPL242C IQG1 SGTC_2891 9063876 19.48 µM -0.572827596781727 0.304821829919346 no 2366 0.283380715840483 3423 6472478 SGTC_1892 st058411 7.36 µM -0.573114632002243 0.304724371132234 no 2367 0.283283540357854 3463 3934738 SGTC_1040 k898-0338 155 µM -0.573777435038468 0.304499378597114 no 2368 0.283059210141992 3536 20969351 SGTC_3322 9139058 2.11 µM -0.573882989141551 0.304463554437234 no 2369 0.283023492506534 3504 4908926 YPR165W RHO1 SGTC_621 3584-0052 32.1 µM -0.574924958446976 0.304110019662946 no 2370 0.282671024717855 3504 2273927 SGTC_4 0960-0234 25.671 µM -0.575854409571185 0.303794816186599 no 2371 0.282356796659938 3481 6821112 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.576187565940942 0.303681868824713 no 2372 0.28224420435955 3460 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_258 haloperidol 50.781 µM -0.57814787850649 0.303017659573265 no 2373 0.281582142310018 3444 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2708 st078559 56 µM -0.578301445926419 0.302965654061471 no 2374 0.281530309192748 3432 17250902 SGTC_2384 9036245 200 µM -0.579552246696928 0.302542220009321 no 2375 0.28110830193246 3423 6462766 SGTC_2717 st081029 62.2815 µM -0.579820196159362 0.302451545489498 no 2376 0.281017938308474 3480 5292846 SGTC_618 k072-0232 33.2 µM -0.580389128947505 0.302259058155977 no 2377 0.280826117230411 3448 5872756 YGL099W LSG1 SGTC_57 miconazole 162.5 nM -0.581180194567257 0.301991507897088 no 2378 0.280559507218753 3454 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1893 st059353 36.1 µM -0.58223281087105 0.301635662317771 no 2379 0.280204937756716 3457 3112488 SGTC_1308 1187-1617 41.4 µM -0.582354476091102 0.301594544552799 no 2380 0.280163969329685 3487 2882570 SGTC_716 1683-5115 658 µM -0.583142009956396 0.301328451987619 no 2381 0.279898852640483 3533 723597 SGTC_1495 4469-0029 237 µM -0.583331463407389 0.301264455082877 no 2382 0.279835092880286 3485 793680 SGTC_739 1486-1183 203 µM -0.583532569790759 0.301196528545098 no 2383 0.279767419084232 3502 4346692 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.58390710290656 0.301070043058087 no 2384 0.279641407068542 3465 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2220 6782180 200 µM -0.584108313152883 0.301002101207158 no 2385 0.279573721071026 3441 833803 SGTC_615 k087-0205 167 µM -0.58477471154215 0.300777130526406 no 2386 0.279349605202635 3434 9642773 SGTC_2697 mebhydrolin 72.4 µM -0.587358908221458 0.299905445144388 no 2387 0.27848134268589 3525 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_95 0471-0001 561.058 µM -0.587419908522372 0.299884882717307 no 2388 0.278460863130195 3447 4015405 SGTC_1179 1021-1431 9.29 µM -0.58790322129221 0.299721986681986 no 2389 0.278298627075295 3456 2840958 SGTC_951 1171-0579 82.7 µM -0.590048264881249 0.298999504013135 no 2390 0.277579145958562 3506 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1962 st076595 64.5 µM -0.591558851884801 0.298491190863165 no 2391 0.27707301746295 3483 279619 SGTC_1510 1123-0200 71.5 µM -0.591964764469137 0.29835466815803 no 2392 0.276937091782318 3600 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1849 st056239 19.2 µM -0.592032523105323 0.298331881309683 no 2393 0.276914405006479 3397 5393181 SGTC_164 4100-3994 89.624 µM -0.592908711992416 0.298037295301 no 2394 0.276621123646289 3563 4615967 SGTC_312 4092-0653 6.84 µM -0.595014614959928 0.297329806321843 no 2395 0.275916850878271 3498 1148278 SGTC_476 mead acid 10 µM -0.59554116823551 0.297153028013811 no 2396 0.275740894504173 3513 5312531 An omega 9 fatty acid. SGTC_2284 7945075 39.21 µM -0.595787659622777 0.297070290641377 no 2397 0.275658544338295 3532 1245402 SGTC_1134 3477-0009 42.5 µM -0.596311557631193 0.296894473879942 no 2398 0.275483555722991 3584 3973534 SGTC_397 arbidol 50 µM -0.596673548580534 0.296773019896507 no 2399 0.275362678059331 3545 131410 A RNA synthesis inhibitor. SGTC_190 3970-0790 3.722 µM -0.597114731658338 0.296625026398198 no 2400 0.275215391497993 3501 2832352 SGTC_605 1315-0399 119 µM -0.597756336558966 0.296409862366808 no 2401 0.275001264445579 3583 24020461 SGTC_244 nsc-207895 1.295 µM -0.597995484594565 0.296329681698642 no 2402 0.274921472990538 3406 42640 SGTC_3267 9137951 49.47 µM -0.598947672681923 0.296010534273419 no 2403 0.274603889764461 3478 16643986 SGTC_1212 0520-0165 585 µM -0.599121051879992 0.295952439289214 no 2404 0.274546082093957 3676 5403258 SGTC_1966 st070145 16.1 µM -0.599776114204701 0.295732991740167 no 2405 0.274327727015756 3459 3748532 SGTC_2465 5809242 33.21 µM -0.599890651093461 0.295694629271269 no 2406 0.274289556691314 3508 2731748 SGTC_2965 9082772 38.63 µM -0.601798318042032 0.295056020440221 no 2407 0.273654197430416 3580 16459634 SGTC_2920 7982904 15.77 µM -0.602316647684333 0.294882614702686 no 2408 0.273481690697297 3486 6456808 SGTC_2427 5545055 42.75 µM -0.603426915724539 0.294511335772319 no 2409 0.273112360538114 3513 5372858 SGTC_167 3672-0051 66.205 µM -0.603839902175438 0.294373286201751 no 2410 0.272975043884099 3498 3237971 SGTC_475 α-linolenic acid 10 µM -0.606159724725624 0.293598391672467 no 2411 0.272204347183102 3622 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2674 ligustilide 100 µM -0.607806515667778 0.293048884917562 no 2412 0.271657903675537 3506 5319022 A signalling regulator. SGTC_3008 9078912 71.4286 µM -0.608845768355994 0.292702349302994 no 2413 0.271313336779103 3522 16648731 SGTC_3113 9123498 49.47 µM -0.610353747073019 0.292199857155524 no 2414 0.27081375020228 3566 8897275 SGTC_3341 9147222 25.867 µM -0.615604622438624 0.290453288025634 no 2415 0.269077749869077 3525 1939759 SGTC_3212 9128307 49.47 µM -0.616389503634479 0.290192637808126 no 2416 0.268818739622368 3369 27243542 SGTC_3346 9158254 43.5805 µM -0.616527638608606 0.29014677607996 no 2417 0.268773168138739 3504 17639500 SGTC_878 0828-0289 13.7 µM -0.617008922022165 0.289987013329572 no 2418 0.268614420427706 3558 745350 YLR208W SEC13 SGTC_1822 st052468 42 µM -0.61711018369915 0.289953404616679 no 2419 0.268581026026806 3481 2873678 SGTC_868 0527-0199 213 µM -0.61776702117456 0.289735444863599 no 2420 0.268364462732783 3459 2849450 SGTC_3069 9117009 49.47 µM -0.618863633497323 0.28937172513227 no 2421 0.268003098821892 3423 41904981 SGTC_197 4544-0043 41.561 µM -0.618945819848295 0.289344474555105 no 2422 0.267976026031526 3538 896523 SGTC_662 k832-1615 104 µM -0.619492879512588 0.289163116391397 no 2423 0.267795855638767 3524 5878478 SGTC_2624 nerol 100 µM -0.620724126411609 0.288755135929073 no 2424 0.267390576190813 3512 637566 A natural product oil. SGTC_1553 gossypol 38.6 µM -0.621927236257729 0.288356740830755 no 2425 0.266994857472891 3495 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1523 st012844 44.7 µM -0.622823038505297 0.288060275300339 no 2426 0.266700408499377 3550 4274103 SGTC_1911 st060208 74.3 µM -0.623385313252105 0.287874264127509 no 2427 0.266515673445847 3527 688783 SGTC_777 1315-0167 517 µM -0.625109938218809 0.287304079516614 no 2428 0.265949452855845 3531 4221767 SGTC_3251 9135047 49.47 µM -0.625488406628254 0.287179024220318 no 2429 0.265825277522863 3533 17682963 SGTC_2457 5731572 11.68 µM -0.627431447214693 0.286537401755288 no 2430 0.265188229724837 3590 2865357 SGTC_769 0302-0231 76 µM -0.629049374630517 0.28600365620276 no 2431 0.264658366116855 3584 571869 YER009W NTF2 SGTC_1042 0350-0096 82 µM -0.629279463306289 0.285927789579682 no 2432 0.264583056916209 3560 3122515 SGTC_1636 st007707 68.9 µM -0.629566946406779 0.285833011867906 no 2433 0.264488977549105 3610 403051 SGTC_906 1165-0455 526 µM -0.629790697643742 0.285759255679884 no 2434 0.264415766332499 3552 3252859 SGTC_2665 lovastatin 100 µM -0.630532559547096 0.285514776986385 no 2435 0.264173103556687 3574 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2483 5729050 27.16 µM -0.63054179073984 0.285511735497712 no 2436 0.264170084751357 3607 2865180 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.630741761770715 0.285445852930808 no 2437 0.264104694090282 3519 1241132 A phosphatase inhibitor. SGTC_2199 6590217 200 µM -0.632089228148859 0.285002104739808 no 2438 0.263664286777817 3503 703109 SGTC_417 st075190 100 µM -0.634355696672745 0.284256453242552 no 2439 0.262924357820568 3593 222757 SGTC_2960 9079389 5.97 µM -0.643449320902913 0.281274132338615 no 2440 0.259966294549905 3570 16457355 SGTC_1801 st050089 28.441 µM -0.644129306588833 0.281051734469007 no 2441 0.259745793851314 3601 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2793 7325131 81.82 µM -0.645202542213894 0.280700892221985 no 2442 0.259397969479084 3544 4176441 SGTC_519 k048-0011 62.8 µM -0.64753585382204 0.279938861090461 no 2443 0.25864259880095 3576 6836379 SGTC_2138 5575593 77.673 µM -0.648146398706536 0.279739630281524 no 2444 0.258445133237459 3589 762213 SGTC_558 k064-0027 21.3 µM -0.649596488827498 0.279266718027079 no 2445 0.257976450850057 3586 5088526 SGTC_1628 st004252 77.7 µM -0.649945670167725 0.279152898942076 no 2446 0.257863658149821 3580 692968 SGTC_528 3492-0019 172 µM -0.650423590441047 0.278997152703162 no 2447 0.257709321637882 3617 2869262 SGTC_2027 5150920 200 µM -0.651970260105692 0.278493408785344 no 2448 0.257210178957982 3589 786715 SGTC_1847 st056231 15 µM -0.652074753966739 0.278459391552599 no 2449 0.257176474735847 3629 5393180 SGTC_3176 9106582 49.47 µM -0.652336182091613 0.278374294356701 no 2450 0.257092161836747 3506 17018027 SGTC_2259 7964009 200 µM -0.652527753345638 0.27831194424559 no 2451 0.257030387528568 3618 313134 SGTC_3163 9099914 49.47 µM -0.65358900241256 0.277966666115816 no 2452 0.256688315721975 3618 16268368 SGTC_1641 st009299 47.1 µM -0.656058301332046 0.277164087961032 no 2453 0.255893306380223 3566 4046054 SGTC_2396 5342950 42.78 µM -0.656110937608602 0.277146992326426 no 2454 0.255876373733738 3594 1886677 SGTC_3009 9080819 71.4286 µM -0.656599152069031 0.276988450685378 no 2455 0.255719347126144 3600 17027216 SGTC_1448 4255-0083 152 µM -0.656880687184156 0.27689704580748 no 2456 0.255628818601852 3645 5399660 SGTC_2248 tofa 1.1 µM -0.65831980622839 0.27643004364801 no 2457 0.255166326811546 3562 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2970 9090938 41.86 µM -0.658687573660635 0.276310763061729 no 2458 0.255048207093535 3625 17217104 SGTC_302 1094-0063 18.9 µM -0.659187710176624 0.276148590814353 no 2459 0.254887618922165 3564 5440289 SGTC_1307 1187-1599 12.2 µM -0.660494643428731 0.275725030605356 no 2460 0.254468227410056 3585 1538471 SGTC_207 4185-0010 4.486 µM -0.66178269000118 0.275307904000165 no 2461 0.254055250648353 3670 3761753 SGTC_18 0111-0177 500 nM -0.663789184916816 0.274658731339211 no 2462 0.253412624312546 3689 721752 SGTC_1977 st070720 65.3 µM -0.664305467910924 0.274491817577738 no 2463 0.253247411058518 3606 682188 SGTC_2675 theaflavin digallate 100 µM -0.664582427824706 0.274402297354364 no 2464 0.253158805785988 3611 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_976 1348-1067 47.6 µM -0.66465778658717 0.274377942051896 no 2465 0.253134699762857 3662 5310671 YGL099W LSG1 SGTC_930 2810-3379 265 µM -0.664799423170524 0.274332169216701 no 2466 0.253089395827037 3667 1015764 SGTC_1679 SEC14.276 6.7 µM -0.666206286545991 0.273877716584599 no 2467 0.252639627624354 3644 1005053 YMR079W SEC14 SGTC_1964 st076914 61 µM -0.666482071141571 0.273788674801992 no 2468 0.252551509847508 3637 24208661 SGTC_1938 st074717 56.4 µM -0.667023006425636 0.27361406616619 no 2469 0.252378719043929 3536 17250979 SGTC_1834 st055981 52.8 µM -0.667552689848847 0.273443142931665 no 2470 0.252209582821932 3659 471719 YDL150W RPC53 SGTC_1176 0848-0131 83.3 µM -0.667737870355783 0.273383399615253 no 2471 0.252150465887704 3678 6769040 SGTC_2742 clothiapine 36.27 µM -0.668468225731681 0.273147833895556 no 2472 0.251917378871238 3576 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.669128269171276 0.272935032849611 no 2473 0.251706829207132 3660 368090 SGTC_1443 4112-3303 14 µM -0.670120233991115 0.272615373513729 no 2474 0.251390573600676 3629 704433 SGTC_1696 st025591 34.7925 µM -0.670616740938997 0.272455444628191 no 2475 0.251232357474778 3635 2787147 SGTC_723 4182-0001 115 µM -0.671362535225802 0.272215305873029 no 2476 0.250994802821974 3585 744821 YLR208W SEC13 SGTC_1122 capsaicin 818.572 nM -0.671834525070586 0.272063383946446 no 2477 0.250844523360244 3666 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1472 k841-0093 193 µM -0.672510262062743 0.271845954231684 no 2478 0.250629454656687 3690 X1472 SGTC_2445 5742597 35.57 µM -0.67396674614768 0.271377600246947 no 2479 0.250166227744021 3595 1774255 SGTC_2366 9070441 60.58 µM -0.675145096054495 0.270998978876208 no 2480 0.249791792473854 3637 6837235 SGTC_2588 indole-3-carbinol 100 µM -0.675674302389101 0.270829022794586 no 2481 0.249623727486874 3626 3712 Induces cell cycle arrest. SGTC_424 splitomicin 100 mM -0.67619371622853 0.270662263349708 no 2482 0.249458830820696 3608 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1490 4089-0339 670 nM -0.677601351464126 0.270210595572192 no 2483 0.249012244493359 3606 742542 SGTC_1379 2144-0755 36.5 µM -0.678826678247603 0.269817732189604 no 2484 0.248623843941424 3669 5392327 SGTC_3202 9113761 49.47 µM -0.678862975080828 0.26980609908811 no 2485 0.248612343598943 3680 4798415 SGTC_848 0368-0089 85.6 µM -0.679183934684425 0.269703242761922 no 2486 0.248510662614556 3623 762535 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.679381055555176 0.269640082154339 no 2487 0.248448225104995 3662 676296 Flavone; oxidizing agent. SGTC_937 3122-0005 46.7 µM -0.679664048345776 0.269549419798635 no 2488 0.248358602512364 3636 759535 SGTC_2381 9035592 200 µM -0.679675998617741 0.26954559162807 no 2489 0.248354818292197 3600 4749657 SGTC_1127 asiatic acid 681.4 nM -0.680220366709822 0.269371236715014 no 2490 0.248182469143684 3628 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1375 2910-0797 186 µM -0.680640815858601 0.269236610345486 no 2491 0.248049396907526 3638 742508 SGTC_3028 9087778 49.47 µM -0.682766131735748 0.268556608404923 no 2492 0.247377316981265 3609 17217395 SGTC_478 N-arachidonylglycine 10 µM -0.683261072856313 0.268398374350254 no 2493 0.247220943621748 3586 5283389 SGTC_328 k915-0120 63.5 µM -0.684515055389592 0.267997682627343 no 2494 0.246824992892634 3623 6624543 SGTC_268 camptothecin 39.6153 µM -0.684756088959082 0.267920698410757 no 2495 0.246748924354728 3658 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2644 guaiazulene 100 µM -0.685216373366225 0.267773718157083 no 2496 0.246603696638325 3669 3515 A coloring agent. SGTC_1395 3486-0190 4.35 µM -0.685422786991206 0.267707818352231 no 2497 0.24653858443112 3673 6748079 SGTC_2287 7945887 168.79 µM -0.685586094167382 0.267655686543736 no 2498 0.246487076477193 3675 1245853 SGTC_1664 st014217 9.02 µM -0.686468742983123 0.267374011161928 no 2499 0.246208784164878 3702 3982782 SGTC_82 0054-0107 293.755 µM -0.686502402473401 0.267363272534812 no 2500 0.246198174925176 3658 3104697 SGTC_75 0159-0059 199.013 µM -0.689092313778425 0.266537647666902 no 2501 0.245382588311636 3731 5377270 SGTC_1072 oxiconazole 14.9 nM -0.689281503475796 0.266477387403446 no 2502 0.245323067717655 3674 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1121 fusaric acid 630.51 nM -0.689461238990191 0.266420144848565 no 2503 0.245266528674534 3662 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2869 9037858 32.47 µM -0.689573249050591 0.266384474789291 no 2504 0.245231297436123 3630 27187042 SGTC_2913 7966556 36.57 µM -0.691427069871599 0.265794469169796 no 2505 0.244648598729992 3591 2976516 SGTC_2277 7947813 106.88 µM -0.691704426329788 0.265706253413614 no 2506 0.244561483353668 3711 1246798 SGTC_426 0988-0037 14.6 µM -0.693329366130201 0.265189724879848 no 2507 0.244051439029572 3667 5383008 SGTC_1976 st070609 63.5 µM -0.694925396106186 0.264682882908691 no 2508 0.243551028129553 3615 682556 SGTC_886 0866-0150 153 µM -0.695723860206871 0.264429504313203 no 2509 0.243300889997868 3693 271463 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.697814425452388 0.26376668531598 no 2510 0.242646628238741 3727 5024745 SGTC_289 k017-0060 526 µM -0.6990151314616 0.263386381867218 no 2511 0.24227128727916 3657 5512909 SGTC_1097 itavastatin 7.23 µM -0.700477055206484 0.262923720317332 no 2512 0.241814714733441 3701 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2160 5660466 132.927 µM -0.702465354103728 0.262295141983053 no 2513 0.241194500358513 3636 2859134 SGTC_1005 4092-0690 4.4 µM -0.704471164225115 0.26166180851033 no 2514 0.240569700798081 3685 1529343 SGTC_1338 1486-1223 76 µM -0.705622308809716 0.26129868997415 no 2515 0.240211523537183 3710 3444526 SGTC_69 0096-0274 206.684 µM -0.705681267096237 0.261280099067273 no 2516 0.240193186563717 3792 6741392 SGTC_584 0986-0246 15.4 µM -0.706373287313782 0.261061939948459 no 2517 0.239978014206164 3772 53315 YDR232W HEM1 SGTC_3097 9117246 49.47 µM -0.706470639054153 0.261031257363098 no 2518 0.23994775271212 3712 16423892 SGTC_713 1488-1073 324 µM -0.707147638863486 0.260817936970819 no 2519 0.239737366937163 3664 3312542 SGTC_3087 9117406 49.47 µM -0.708337944582102 0.260443093170309 no 2520 0.239367709412779 3664 42546093 SGTC_1195 1502-0147 41.1 µM -0.70834542296604 0.260440739000704 no 2521 0.239365387934403 3690 817940 SGTC_3321 9137793 26.8275 µM -0.710244526919594 0.259843262559012 no 2522 0.238776256585568 3674 4904192 SGTC_2894 9048625 32.47 µM -0.710321438820709 0.259819080240336 no 2523 0.23875241405143 3727 4092861 SGTC_2145 5634607 200 µM -0.710745387670778 0.259685804857501 no 2524 0.238621014143056 3656 308662 SGTC_1516 st013856 110 µM -0.71234867217069 0.259182104915655 no 2525 0.238124445641653 3697 5281404 A mutagen and neurotoxin. SGTC_399 oxolinic acid 75 µM -0.712867169544933 0.259019318012047 no 2526 0.237963978146385 3678 4628 A DNA gyrase inhibitor. SGTC_2976 9009005 19.48 µM -0.713472355496295 0.258829381349856 no 2527 0.237776756784037 3708 2993148 SGTC_1136 pergolide 1.05886 µM -0.713862754721265 0.258706893417565 no 2528 0.237656025094283 3691 47811 A dopamine receptor agonist. SGTC_925 2064-1272 59.6 µM -0.714780274088496 0.258419139474377 no 2529 0.237372412975685 3700 6815817 SGTC_2440 5628896 157.78 µM -0.716845209720274 0.257772137982868 no 2530 0.236734806187881 3739 5522048 SGTC_2329 6138490 200 µM -0.716972317662548 0.257732339034491 no 2531 0.23669558884602 3741 720019 SGTC_1145 3546-0597 10.2 µM -0.717175423359909 0.257668750942343 no 2532 0.236632930899183 3679 875334 SGTC_317 4495-0002 170 µM -0.717381043854293 0.257604383818843 no 2533 0.236569506435901 3709 15991618 SGTC_2137 5261020 140 µM -0.717874458457603 0.257449960135388 no 2534 0.236417348890309 3678 763655 SGTC_2174 5790901 200 µM -0.719263465666244 0.257015501746864 no 2535 0.235989300913845 3727 786020 SGTC_2050 5263056 171 µM -0.719272520167576 0.257012670900876 no 2536 0.235986512005451 3725 763468 YGL055W OLE1 SGTC_77 0828-0286 12.516 µM -0.719503392349313 0.256940495311033 no 2537 0.235915406399373 3676 745345 SGTC_594 1487-1584 10.8 µM -0.719727264638053 0.256870518109889 no 2538 0.235846467947479 3695 5013332 SGTC_1804 st050076 49.1 µM -0.719999091927111 0.256785564639778 no 2539 0.235762777330726 3726 3895976 SGTC_1556 plumbagin 1.48 µM -0.720182789938141 0.256728162264133 no 2540 0.235706229369495 3631 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2720 fluspirilene 36.88 µM -0.72066410020252 0.256577793017403 no 2541 0.235558102579749 3687 3396 An atypical antipsychotic. SGTC_1771 st048882 4.1505 µM -0.721145872046358 0.256427325516199 no 2542 0.235409885180236 3706 4580403 SGTC_3109 9122853 49.47 µM -0.721390145967057 0.256351051192311 no 2543 0.235334753830119 3762 1234709 SGTC_1279 0874-0590 65.2 µM -0.722026293201477 0.256152470266845 no 2544 0.235139156106652 3742 3523074 SGTC_125 0133-0007 11.75 µM -0.722225645736315 0.25609025651409 no 2545 0.23507787918455 3787 26541 SGTC_1445 4239-0156 97.7 µM -0.72283235924922 0.255900962430495 no 2546 0.23489144205277 3770 4008346 SGTC_2746 daunorubicin 9.88 µM -0.723337104730471 0.255743537942284 no 2547 0.234736400990204 3598 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1250 0485-0349 40.2 µM -0.725016141952973 0.255220229016895 no 2548 0.234221063840383 3727 6842794 YDL195W SEC31 SGTC_369 0957-0393 4.5 µM -0.725934903950948 0.254934113796179 no 2549 0.233939338903896 3724 6997992 SGTC_2735 sertaconazole 140 nM -0.726411164024252 0.254785865889898 no 2550 0.233793374628574 3777 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_597 k018-0003 82.8 µM -0.726773555696981 0.254673092625645 no 2551 0.233682342586022 3807 6786234 SGTC_646 4092-0839 27.3 µM -0.726984210956596 0.254607550482764 no 2552 0.233617814022761 3762 877796 SGTC_817 1391-0715 46 µM -0.728812903141826 0.254038952507351 no 2553 0.233058058801055 3706 1353946 SGTC_1767 st044992 70.3 µM -0.729660831962666 0.25377553098274 no 2554 0.232798764181394 3738 9600693 SGTC_1026 k007-1105 30.6 µM -0.732957188867119 0.252752833384613 no 2555 0.231792270475995 3727 7066794 SGTC_447 ml7 120 µM -0.733340310983391 0.252634110342096 no 2556 0.231675447273868 3744 4216 Selective myosin light chain kinase inhibitor. SGTC_1951 sophoraflavanone G 9.2 µM -0.733627550937024 0.252545118825215 no 2557 0.231587882388244 3744 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2522 biochanin a 4.94 µM -0.733898381328377 0.252461226382197 no 2558 0.231505336844787 3686 5280373 A possible chelator. SGTC_257 daunorubicin 18.5 µM -0.734024860774236 0.252422053130519 no 2559 0.231466793191617 3771 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2850 9015429 58.44 µM -0.736732556539881 0.25158419377516 no 2560 0.230642502140311 3788 6457570 SGTC_943 3253-1379 105 µM -0.737529878669911 0.251337753675482 no 2561 0.230400090078221 3722 668464 SGTC_479 n-linoleoylglycine 10 µM -0.737990616178824 0.251195404944906 no 2562 0.230260075736634 3760 6433346 An anti-infammatory. SGTC_249 wiskostatin 11.211 µM -0.738298189112297 0.25110040143645 no 2563 0.230166633343839 3731 2775510 A n-wasp and actin depolymerizer. SGTC_752 1896-0090 130 µM -0.739142675344855 0.250839653253424 no 2564 0.229910182770775 3729 772567 SGTC_1644 st010134 20.9 µM -0.739879195837767 0.250612358239494 no 2565 0.2296866494912 3735 3818134 SGTC_1872 amphotericin b 148 nM -0.741861414226654 0.250001175105592 no 2566 0.229085653127897 3763 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2999 9069765 71.4286 µM -0.74186626872867 0.249999679274407 no 2567 0.229084182356516 3768 2097066 SGTC_2597 laccaic acid a 100 µM -0.742035303498626 0.249947597083253 no 2568 0.229032973094477 3747 5491415 A textile dye. SGTC_2446 5162541 200 µM -0.742608616799428 0.249770993404217 no 2569 0.228859335062844 3716 1549321 SGTC_2638 epoxomicin 18 µM -0.743081402746782 0.249625406077806 no 2570 0.228716199116582 3756 9915668 A protesome inhibitor. SGTC_790 1575-0012 79.1 µM -0.743274530472949 0.249565948267357 no 2571 0.22865774416 3830 378741 YLR208W SEC13 SGTC_191 3914-0123 66.505 µM -0.743453547592066 0.249510841378816 no 2572 0.228603567626267 3685 3144412 SGTC_719 2810-4230 27.3 µM -0.744772254738429 0.249105102716474 no 2573 0.228204705212144 3740 721079 SGTC_2389 9091542 195.52 µM -0.745278678524968 0.248949380013655 no 2574 0.228051633911421 3768 3626624 YOL127W RPL25 SGTC_3095 9117207 49.47 µM -0.746322513307455 0.248628569712499 no 2575 0.227736307388133 3732 17015229 SGTC_912 3474-0017 2.18 µM -0.746635428143849 0.248532441949238 no 2576 0.227641828433875 3764 3360550 SGTC_1519 esterone 74 µM -0.746841119166067 0.248469264241406 no 2577 0.227579735785888 3753 698 A steroid. SGTC_1088 bifonazole 369 nM -0.74779403880815 0.248176688015037 no 2578 0.227292199159788 3681 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1456 k015-0012 13 µM -0.748712887751851 0.247894746656729 no 2579 0.227015137087931 3797 2989616 SGTC_299 1273-0059 1.44 µM -0.749695853082985 0.247593321074295 no 2580 0.226718952844146 3697 2848077 SGTC_3257 9139206 32.98 µM -0.749989879610044 0.247503196115953 no 2581 0.226630400016678 3747 4910041 SGTC_990 3985-0011 41.3 µM -0.750143658645407 0.247456066775804 no 2582 0.226584093711904 3760 5399565 YGL099W LSG1 SGTC_1402 3909-7673 35.9 µM -0.750396983114677 0.247378439765245 no 2583 0.226507823699203 3763 5328014 SGTC_822 1487-0950 154 µM -0.751012039926858 0.247190020157491 no 2584 0.226322704956954 3740 1958375 SGTC_1333 1482-0047 286 µM -0.751693345344678 0.246981395243215 no 2585 0.226117746622086 3730 3811116 SGTC_160 3453-0671 289.699 µM -0.751866491089613 0.246928390697639 no 2586 0.226065675597731 3776 5322268 SGTC_3238 9133470 49.47 µM -0.751930515115868 0.246908792771839 no 2587 0.22604642303443 3761 3534688 SGTC_1274 0865-0114 173 µM -0.753813926136973 0.246332648235647 no 2588 0.225480480299957 3780 870624 SGTC_647 0140-0236 81 µM -0.754088246483201 0.246248792481875 no 2589 0.225398117249838 3764 990837 SGTC_2416 tofa 880 nM -0.75471197353742 0.246058185137987 no 2590 0.225210910324744 3802 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1617 st002906 78 µM -0.755624436095219 0.24577948455534 no 2591 0.224937200367597 3777 5150859 SGTC_2348 9022543 33.42 µM -0.756217472771579 0.245598439625064 no 2592 0.224759409232718 3784 3162678 YDL140C RPO21 SGTC_2354 9060492 162 µM -0.756504572759846 0.245510818176053 no 2593 0.224673365902148 3830 6471895 SGTC_3149 9097855 49.47 µM -0.756545613904902 0.24549829400048 no 2594 0.224661067474019 3775 25236625 YMR079W SEC14 SGTC_2571 chrysanthemic acid 100 µM -0.756585195441656 0.245486215566268 no 2595 0.224649206795212 3789 2743 An insecticide. SGTC_2260 7964312 200 µM -0.756964012430383 0.245370634486418 no 2596 0.224535711569393 3778 231951 SGTC_1970 st070122 35.8 µM -0.757621483410843 0.24517010256975 no 2597 0.224338807641723 3763 102928 SGTC_606 k015-0008 38.6 µM -0.758111007843292 0.245020852440539 no 2598 0.224192265182105 3796 1970475 SGTC_382 3229-0966 23.2 µM -0.758133189826215 0.245014090577732 no 2599 0.224185626142682 3764 5722370 SGTC_619 1652-1634 108 µM -0.759752647618627 0.244520693163714 no 2600 0.223701226187245 3738 5400454 SGTC_2184 6075246 200 µM -0.76034969967521 0.244338925473123 no 2601 0.223522790743915 3824 2267320 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.760388238119387 0.244327195256683 no 2602 0.223511275896577 3705 756377 SGTC_189 3970-0742 2.116 µM -0.7605028354186 0.244292316266543 no 2603 0.223477037524821 3761 2891807 SGTC_2745 rifampicin 24.3 µM -0.761386117417241 0.24402356944361 no 2604 0.223213238453762 3725 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2285 7945142 200 µM -0.761678902180561 0.243934522142278 no 2605 0.223125835128672 3809 2970608 SGTC_1000 4048-0884 8.67 µM -0.762623563253161 0.243647333331576 no 2606 0.22284396387758 3770 13040088 SGTC_1180 1193-0155 285 µM -0.763459523526997 0.243393343272586 no 2607 0.22259469644444 3785 2921347 SGTC_1995 st072814 61.1 µM -0.763858408235509 0.243272200451176 no 2608 0.222475812664113 3749 5769371 SGTC_781 4335-2806 94.4 µM -0.763955031993804 0.243242860348125 no 2609 0.22244702032398 3909 845254 SGTC_20 0481-0013 4.944 µM -0.764690967043022 0.24301945417446 no 2610 0.222227793153545 3775 182045 SGTC_1315 1237-0019 3.69 µM -0.765698707252421 0.242713716834789 no 2611 0.221927798225949 3762 825140 SGTC_2584 androsterone 48.74 µM -0.767620466822976 0.242131253638731 no 2612 0.221356349688768 3803 2754130 A steroid. SGTC_2112 5488546 200 µM -0.769420480981372 0.241586378173216 no 2613 0.220821866989564 3768 600757 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.770368472775734 0.24129968303913 no 2614 0.220540674754703 3806 23847180 SGTC_2988 9073640 71.4286 µM -0.772774539315381 0.240572862438397 no 2615 0.219827911997231 3814 9102229 SGTC_1226 3909-7979 35.4 µM -0.773319373181174 0.240408445592744 no 2616 0.219666696561874 3806 6615510 SGTC_704 1310-0270 142 µM -0.773982143782449 0.240208521014978 no 2617 0.21947067539638 3771 5718033 SGTC_2738 aclarubicin 5.55 µM -0.774897718990786 0.239932487098064 no 2618 0.219200050055081 3729 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1524 corynanthine 62.1 µM -0.775129229917478 0.239862717002147 no 2619 0.219131650549582 3904 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3129 9127257 49.47 µM -0.77555276749573 0.239735104774362 no 2620 0.219006548866106 3798 837894 SGTC_1245 0418-0076 17.2 µM -0.775660947649172 0.239702515944002 no 2621 0.21897460192639 3832 6790114 SGTC_2401 5128683 200 µM -0.775748469800102 0.23967615202193 no 2622 0.218948757512412 3779 708373 SGTC_395 anisomycin 6.25 µM -0.776308591309347 0.239507466499176 no 2623 0.218783400795257 3800 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2949 9072542 2.23 µM -0.77692239314627 0.239322689135357 no 2624 0.218602279348274 3869 16457352 SGTC_2797 7859098 81.82 µM -0.777073241057265 0.239277290182391 no 2625 0.218557780167483 3824 972681 SGTC_3219 9131112 49.47 µM -0.778132607757706 0.238958597408578 no 2626 0.218245420641758 3766 17612988 YMR079W SEC14 SGTC_1779 st039427 55 µM -0.780527035248146 0.238239129814268 no 2627 0.217540360345849 3805 1124498 SGTC_256 clotrimazole 625 nM -0.782591822021982 0.237619665411782 no 2628 0.216933422694171 3765 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1320 1313-0481 95.3 µM -0.782641387526195 0.237604805950375 no 2629 0.216918865108584 3792 6813365 YLR208W SEC13 SGTC_2453 5731132 22.18 µM -0.782687167279038 0.237591081889081 no 2630 0.216905419914878 3826 1362040 SGTC_2716 st080858 38.6235 µM -0.782718638216123 0.237581647641584 no 2631 0.216896177399853 3797 5296050 SGTC_688 0527-0193 473 µM -0.783581854797677 0.237322955762365 no 2632 0.216642753159524 3821 4007154 SGTC_2425 5628681 7.85 µM -0.784773478604434 0.236966099908217 no 2633 0.21629319626492 3876 5714958 SGTC_2514 salinomycin 42.74 µM -0.784934607568695 0.236917869228122 no 2634 0.216245954960834 3899 23682228 A polyether potassium ionophore. SGTC_3323 9138564 53.9225 µM -0.786518801114845 0.236443960565488 no 2635 0.215781804414475 3803 43912313 YNL103W MET4 SGTC_175 3793-3120 23.7 µM -0.787239336375992 0.23622858648392 no 2636 0.215570887037554 3825 5322297 SGTC_762 1165-0429 115 µM -0.787554693326665 0.236134357627685 no 2637 0.21547861237336 3766 5967793 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.787676086995164 0.23609809064273 no 2638 0.215443098224079 3848 94937 An inhibitor of serotonin biosynthesis. SGTC_2953 9074162 66.49 µM -0.78781221098783 0.236057426547472 no 2639 0.215403278704827 3747 16451992 SGTC_2820 7989630 71.43 µM -0.78984842807421 0.235449611599193 no 2640 0.214808146388636 3716 2984098 SGTC_3208 9114115 49.47 µM -0.790278489355378 0.235321347988988 no 2641 0.214682573165165 3842 650895 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.791233677557524 0.235036605944868 no 2642 0.214403821233591 3775 279621 SGTC_1118 chelidonine 707.474 nM -0.791286893607408 0.235020747815335 no 2643 0.214388297421836 3797 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2092 5303694 80.6725 µM -0.793603896312971 0.23433086549012 no 2644 0.213713031734894 3808 1963699 SGTC_985 1493-0307 8.71 µM -0.794507698625955 0.234062064565345 no 2645 0.213449964457874 3815 3278274 SGTC_1649 st011737 51.3 µM -0.794633277380955 0.234024729555032 no 2646 0.213413427531598 3825 1761035 SGTC_384 k007-0144 5.16 µM -0.795406789877471 0.23379483428902 no 2647 0.213188455777636 3814 6824886 SGTC_743 1275-0778 158 µM -0.79894499965511 0.232744842046312 no 2648 0.212161152224694 3832 2849257 YMR203W TOM40 SGTC_2843 9000894 45.46 µM -0.798997988516571 0.232729137117538 no 2649 0.212145789171664 3752 2242070 SGTC_3128 9127691 49.47 µM -0.799626024030914 0.23254304374748 no 2650 0.211963752467943 3867 41316314 SGTC_1269 0831-0796 3.05 µM -0.799662165186752 0.232532337270176 no 2651 0.211953279699625 3844 927758 SGTC_1699 st031318 29.054 µM -0.800636386822793 0.232243836574572 no 2652 0.211671089629684 3895 5340658 SGTC_1874 staurosporine 7.6 µM -0.801251601058128 0.232061753028565 no 2653 0.211493001884783 3888 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1935 st074532 41.6 µM -0.803197624084356 0.231486316665064 no 2654 0.210930259278409 3854 2829742 SGTC_3148 9097893 49.47 µM -0.803325354589532 0.231448574770181 no 2655 0.210893353446957 3843 17174100 SGTC_2046 4110841 106 µM -0.804357013343596 0.231143865354844 no 2656 0.21059540980333 3864 44119630 YMR134W ERG29 SGTC_1817 st052116 64.4 µM -0.804578977908839 0.231078335458354 no 2657 0.210531338611262 3813 4361398 SGTC_1139 k015-0024 46.9 µM -0.805811564442415 0.230714631550026 no 2658 0.210175754491369 3817 2766652 SGTC_108 0509-0257 621.132 µM -0.806437418673085 0.230530080886257 no 2659 0.209995339338732 3815 536624 SGTC_229 benomyl 22.8748 µM -0.809380291118038 0.229663399443143 no 2660 0.209148217621707 3867 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1147 3809-1045 12.3 µM -0.81061074778352 0.229301569432054 no 2661 0.208794621371338 3820 325925 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.812280329031229 0.228811121189412 no 2662 0.20831539761512 3649 4000243 SGTC_1971 st069429 63.5 µM -0.813648875033686 0.228409543172656 no 2663 0.207923065049653 3854 1246522 YGL099W LSG1 SGTC_53 0973-0023 39.979 µM -0.814041296890007 0.228294466334667 no 2664 0.207810646722416 3765 674768 SGTC_1115 galangin 695.678 nM -0.814055978746451 0.22829016154537 no 2665 0.207806441461458 3883 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1687 st020778 55.3625 µM -0.814357614831305 0.228201730526163 no 2666 0.207720056259694 3850 4259299 SGTC_2678 equilin 100 µM -0.815931374093929 0.227740662085185 no 2667 0.20726969339231 3857 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2058 5236698 133 µM -0.818814032261072 0.226897483402093 no 2668 0.206446261858165 3863 766665 SGTC_1941 st076221 61.8 µM -0.819266090888385 0.226765415971846 no 2669 0.206317307306369 3801 2828568 SGTC_1292 0kpi-0043 232 µM -0.820284098377211 0.22646816732798 no 2670 0.206027084651664 3887 3333905 SGTC_2210 7115885 190.385 µM -0.821327777389128 0.226163651374968 no 2671 0.205729794822281 3905 2927039 SGTC_1729 st035615 45.989 µM -0.821743791952836 0.226042334643127 no 2672 0.20561136492395 3930 17385451 SGTC_360 0957-0399 1.01 µM -0.822115404579386 0.22593399736281 no 2673 0.205505609477686 3893 6752301 YPR165W RHO1 SGTC_432 NS 1619 61.3 µM -0.823875191533451 0.22542136057617 no 2674 0.205005238976331 3926 4552 A K+/calcium channel activator. SGTC_1864 st057645 30.4 µM -0.825161068866916 0.225047193334394 no 2675 0.204640076320999 3900 688666 SGTC_2904 7225135 42.03 µM -0.825233616503355 0.225026093766452 no 2676 0.204619485826444 3949 4446116 SGTC_2566 crystal violet carbinol 226 nM -0.826204634656382 0.224743793284024 no 2677 0.204344009807171 3914 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_967 1306-0166 352 µM -0.826621407776649 0.224622688017849 no 2678 0.204225839812409 3813 4437607 SGTC_1685 st024049 53.0905 µM -0.827334137166934 0.224415670060206 no 2679 0.204023850021993 3901 1941139 SGTC_474 dl-dihydrosphingosine 5 µM -0.83032243487041 0.223548874806012 no 2680 0.203178253466772 3868 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2689 tacrolimus 100 µM -0.831846063199704 0.223107660256978 no 2681 0.202747919854458 3896 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_517 1365-0151 113 µM -0.832623284864853 0.222882782370359 no 2682 0.202528611275204 3954 768657 SGTC_3312 9133330 71.43 µM -0.833509089842544 0.222626644990463 no 2683 0.202278836745076 3936 17617324 SGTC_3316 9136639 10.545 µM -0.834230996318926 0.222418024292872 no 2684 0.202075413770033 3914 4903665 SGTC_2684 capsaicin 100 µM -0.834599028598037 0.222311711128946 no 2685 0.201971754641281 3901 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1906 st060206 94.7 µM -0.835477844194627 0.222057965734483 no 2686 0.201724358231049 3904 5133468 SGTC_2802 7925815 54.55 µM -0.835542960045369 0.222039171048268 no 2687 0.201706034616266 3876 1262923 SGTC_201 4262-0159 12.803 µM -0.836654678895955 0.221718430683996 no 2688 0.201393350507429 3910 1341029 SGTC_438 sphingosine 6.67 µM -0.837277961113067 0.221538724321289 no 2689 0.201218172163225 3853 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1350 1495-0454 146 µM -0.837519654196573 0.221469061145828 no 2690 0.201150267021558 3908 1069057 SGTC_1734 st037168 69.4 µM -0.837794374035196 0.221389893880973 no 2691 0.201073099501881 3957 708907 SGTC_1380 2291-0730 164 µM -0.839260667794746 0.220967619115993 no 2692 0.200661524823297 3931 2999191 SGTC_1724 st037281 8.293 µM -0.840033796379386 0.220745153245735 no 2693 0.200444718789148 3889 574124 YDL195W SEC31 SGTC_737 1950-0117 57.9 µM -0.841109074974922 0.220435957809339 no 2694 0.200143415805387 3822 5393513 SGTC_1740 st038286 13.222 µM -0.841381968667409 0.220357526971893 no 2695 0.20006699180665 3932 716786 SGTC_926 2268-1401 59.4 µM -0.841627946760384 0.220286845505089 no 2696 0.199998120568453 3869 2931578 SGTC_3291 9121177 71.43 µM -0.843160375358869 0.219846797102068 no 2697 0.199569378048443 3904 17015612 SGTC_1252 0493-0875 34.8 µM -0.843308941370669 0.219804162098534 no 2698 0.199527841716806 3877 3960963 SGTC_2128 5255449 168.493 µM -0.844217237971168 0.219543605247317 no 2699 0.199274011816476 3898 736008 SGTC_337 1315-0038 354 µM -0.847636763909544 0.218564261820126 no 2700 0.198320146686077 3870 1626437 SGTC_1701 st028638 40.4 µM -0.848323934857199 0.218367761782585 no 2701 0.19812879572812 3850 3490878 SGTC_1806 st050005 60.3 µM -0.849359208982352 0.218071912094641 no 2702 0.197840721848684 3919 5194765 SGTC_2123 5259487 200 µM -0.85043300381279 0.217765298613647 no 2703 0.197542196759154 3912 2173474 SGTC_3228 9131799 49.47 µM -0.852187181630527 0.217264942591336 no 2704 0.197055104991117 3910 17015818 SGTC_3264 9137442 49.47 µM -0.852442746023121 0.217192101684177 no 2705 0.196984201797892 3869 17015726 SGTC_1201 1889-3372 45.9 µM -0.853774529557392 0.216812745406723 no 2706 0.196614964840525 3790 5392199 SGTC_1296 1068-0102 11.9 µM -0.854188688959616 0.216694850945154 no 2707 0.196500224679837 3927 767053 SGTC_1183 1254-0324 198 µM -0.855728901190851 0.216256740161426 no 2708 0.196073875079421 3992 5799357 SGTC_1265 0819-1001 68.8 µM -0.857722567741867 0.215690407281867 no 2709 0.195522837702774 3877 3106768 SGTC_2827 7993847 71.43 µM -0.858387352177427 0.215501755953906 no 2710 0.195339304583845 3981 2985692 SGTC_1775 st081588 35.1725 µM -0.86014961807528 0.215002126673427 no 2711 0.194853286433242 3939 1426443 YGL099W LSG1 SGTC_3059 1327-0034 3 µM -0.860405245376252 0.214929708336995 no 2712 0.194782847695459 3841 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2449 5812982 45.77 µM -0.861051569191379 0.214746670225965 no 2713 0.19460482066296 3892 776185 SGTC_720 r052-1644 49.9 µM -0.861436493298997 0.21463770323889 no 2714 0.194498842081043 3940 1422863 YOR257W CDC31 SGTC_874 0599-0792 117 µM -0.862688711986823 0.21428343888235 no 2715 0.194154320169692 3902 765305 SGTC_2818 7996756 12.99 µM -0.863157900449762 0.214150788732688 no 2716 0.19402532851939 3932 2241621 SGTC_610 4215-0184 155 µM -0.863431198385465 0.214073543275905 no 2717 0.193950216148846 3937 5605015 SGTC_3328 9140624 29.0385 µM -0.866865042619882 0.213104377610768 no 2718 0.193007979569697 3966 4904392 SGTC_887 0885-0007 9.62 µM -0.868211367507001 0.212725091439959 no 2719 0.192639316169603 4017 5719458 SGTC_2831 7999036 19.48 µM -0.871357754248461 0.211840230889216 no 2720 0.191779422464899 4013 2988270 SGTC_1442 4112-3290 3 µM -0.872319932012096 0.21157006753209 no 2721 0.191516933460691 3908 704353 SGTC_1435 4092-0789 56.7 µM -0.872583454592215 0.211496110020023 no 2722 0.191445081022609 3905 2248285 SGTC_1673 st016611 27.3 µM -0.874374974495324 0.210993722066519 no 2723 0.190957040660142 3981 5226799 SGTC_2561 acetosyringone 100 µM -0.875122271054443 0.21078436796722 no 2724 0.190753690180447 3943 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_60 0986-0278 202 µM -0.875712015194321 0.210619238008804 no 2725 0.190593305904914 3871 3110598 SGTC_2769 toremifene 3.73 µM -0.875927875026219 0.210558815651667 no 2726 0.190534622296242 3924 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_536 3852-0578 10.6 µM -0.876164574683285 0.210492571613574 no 2727 0.190470285930184 3997 2869208 SGTC_1660 st012960 28.1 µM -0.879047929489812 0.209686602999764 no 2728 0.189687644397172 3935 24207266 SGTC_2677 mitomycin C 100 µM -0.879522922744526 0.209554005010975 no 2729 0.189558904941602 3955 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1300 1094-0077 113 µM -0.880066796868024 0.209402238988089 no 2730 0.189411562443499 3895 5532636 SGTC_1367 1812-0510 76.9 µM -0.880327461716712 0.20932952437815 no 2731 0.189340969975696 3981 1142582 YDR527W RBA50 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.88047807055104 0.20928751757572 no 2732 0.189300189928365 3941 442882 SGTC_471 1-acyl-paf 4 µM -0.881810879782516 0.208915995678934 no 2733 0.188939543572353 3875 16759367 SGTC_960 1222-0186 7.7 µM -0.882312524253812 0.20877626248081 no 2734 0.188803912745593 4003 3126296 SGTC_542 3381-0244 89.3 µM -0.88242140602467 0.208745940711075 no 2735 0.188774482045257 3986 1112843 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.883855381567373 0.208346844496985 no 2736 0.188387142881113 3937 16486 A toxic proline analog. SGTC_1255 0566-0045 221 µM -0.883946341960719 0.208321544088495 no 2737 0.188362589605444 4002 2788469 SGTC_1233 0325-0408 14.2 µM -0.884097820354243 0.2082794147704 no 2738 0.188321704863151 3999 12874 SGTC_2977 9011197 71.43 µM -0.884448108315672 0.208182011595257 no 2739 0.188227181437799 4054 2704722 SGTC_2939 9044578 71.43 µM -0.886290316258464 0.207670198767434 no 2740 0.18773055296082 3904 2653634 SGTC_52 0329-0193 875 nM -0.886643760872017 0.207572087812486 no 2741 0.187635362821932 4065 3739292 SGTC_273 hydroxyurea 18.1 mM -0.887744049917279 0.207266839385444 no 2742 0.187339222578984 4030 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2974 9094440 9.66 µM -0.889669035552167 0.206733437866432 no 2743 0.186821812598585 4008 25236134 SGTC_1800 st050079 29.0735 µM -0.889840259110213 0.206686032279957 no 2744 0.186775832904782 3860 3645560 SGTC_2147 5545932 89.7195 µM -0.890392499147944 0.206533180930097 no 2745 0.186627584291684 3983 797404 SGTC_2687 chenodiol 100 µM -0.891109688145415 0.206334774283141 no 2746 0.186435163979062 4038 5702181 A cholesterol synthesis inhibitor. SGTC_1876 myriocin 605 nM -0.891891797043735 0.206118536685484 no 2747 0.186225465924304 3955 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2840 9008771 71.43 µM -0.892208195076781 0.20603109709228 no 2748 0.186140675222571 3913 2992978 SGTC_2757 clomiphene 4.22 µM -0.892317202744517 0.206000976886615 no 2749 0.186111468078751 4030 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2421 5690543 90.72 µM -0.892544954071547 0.205938054725761 no 2750 0.186050454330843 4000 3397993 SGTC_2068 5226020 147 µM -0.892645008425073 0.205910415742299 no 2751 0.186023654056075 4001 1810509 SGTC_3021 9087658 49.47 µM -0.892936123512854 0.205830010717395 no 2752 0.185945690409509 3908 25237042 SGTC_763 3453-1109 128 µM -0.893208706457039 0.20575474109924 no 2753 0.185872708233499 4000 1560353 SGTC_3006 9075424 71.4286 µM -0.893280433670214 0.205734937439366 no 2754 0.185853506726729 3908 7465181 SGTC_2736 butenafine 14.65 µM -0.89345868359072 0.205685728090851 no 2755 0.185805794223025 3904 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1791 st048313 56.1 µM -0.896045009471611 0.204972509009016 no 2756 0.185114362404726 3952 1204976 SGTC_3042 9091578 49.47 µM -0.897743282489481 0.204504984839009 no 2757 0.1846612142925 3927 25236497 SGTC_897 1000-0139 31.4 µM -0.897958096057794 0.204445893225355 no 2758 0.184603945029117 3923 6151020 SGTC_1895 st058434 18.3 µM -0.901420048854775 0.203494970415837 no 2759 0.183682512773456 3980 5393175 SGTC_136 0097-0015 404.482 µM -0.902034731203731 0.203326406829838 no 2760 0.18351920918906 3967 4861337 SGTC_2439 5492030 7.2 µM -0.90312760199449 0.2030269160555 no 2761 0.183229088112164 3962 5722370 SGTC_2621 lithochol-11-enic acid 100 µM -0.903707869785304 0.202868006344084 no 2762 0.18307516251248 3894 6708711 SGTC_1229 0139-0193 12.2 µM -0.903911762320883 0.202812186831316 no 2763 0.183021095813896 4033 3090752 SGTC_107 0358-0022 2.6945 µM -0.905295658247017 0.202433561197591 no 2764 0.182654387975101 4009 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_642 0335-0876 158 µM -0.90665594868583 0.202061806093066 no 2765 0.182294382626478 4011 6812350 SGTC_1657 st012939 43.4 µM -0.908857756080573 0.201460938582157 no 2766 0.181712607481145 4004 24207257 SGTC_2474 5321570 43.32 µM -0.909304971040254 0.20133902574094 no 2767 0.181594583672095 3992 2841384 SGTC_622 1348-1566 26.3 µM -0.911512930404141 0.200737774354362 no 2768 0.18101258788651 4026 7340407 SGTC_320 4092-0846 5.34 µM -0.911589157443189 0.200717036165503 no 2769 0.180992516102328 3958 1359356 SGTC_3092 9117248 49.47 µM -0.912219327337314 0.200545642564091 no 2770 0.180826635835057 4069 17141857 SGTC_1815 st051655 58.2 µM -0.913090033295957 0.200308972626778 no 2771 0.180597595870033 3939 5984156 SGTC_1788 fluconazole 20 µM -0.913282661477495 0.200256636297565 no 2772 0.180546949446122 4049 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2511 berberine 10.47 µM -0.913450606461307 0.200211013002966 no 2773 0.18050280007817 3965 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2182 6325192 200 µM -0.914780114025992 0.19985006453959 no 2774 0.180153538234492 3904 736248 SGTC_2616 abietic acid 100 µM -0.915612364226462 0.199624315960371 no 2775 0.179935122016048 4005 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2363 9053361 176 µM -0.917304069738589 0.199165912615184 no 2776 0.179491662686669 4066 6469797 YMR079W SEC14 SGTC_2040 5100729 123 µM -0.921307996291469 0.198083493423149 no 2777 0.178444823746715 4002 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2782 7736369 71.43 µM -0.921462249461801 0.198041863894323 no 2778 0.178404570872512 4029 2950836 YOL077C BRX1 SGTC_3261 9137475 49.47 µM -0.921574565878892 0.198011555494628 no 2779 0.178375265131977 3901 17027690 SGTC_2100 5377183 190 µM -0.922143118934424 0.197858175376552 no 2780 0.17822696409576 4023 2844202 SGTC_2919 7978188 46.38 µM -0.927254322858244 0.196482537401836 no 2781 0.176897252032752 3997 2980291 SGTC_1626 st003712 1.76 µM -0.92823298045143 0.196219802515614 no 2782 0.176643365067469 4034 24207035 SGTC_1669 st015249 58.4 µM -0.930680313767421 0.195563713296514 no 2783 0.17600947796187 4084 722793 SGTC_2600 tangeritin 87.95 µM -0.934265431776508 0.194605011405361 no 2784 0.175083495552938 3951 68077 A bioactive flavone. SGTC_1012 4112-3522 18 µM -0.935788514269129 0.194198588645729 no 2785 0.174691043155095 4041 3112398 SGTC_1010 4112-3296 15.2 µM -0.935866540757563 0.194177781811601 no 2786 0.174670953133565 4091 704384 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.939331063723133 0.193255288343234 no 2787 0.173780397229348 4067 5282362 SGTC_2377 9073351 62.6 µM -0.941237399954103 0.192748833735019 no 2788 0.173291607348223 3986 7337946 YHR072W ERG7 SGTC_3007 9078383 71.4286 µM -0.942215639311038 0.192489260909839 no 2789 0.17304112425535 4005 6496995 SGTC_2309 7664088 163.95 µM -0.949231075435702 0.190634004777004 no 2790 0.171251549906192 4053 704922 SGTC_1937 st074714 47.2 µM -0.952285384390778 0.189829723517134 no 2791 0.170476134054466 3984 17250970 SGTC_2929 9013348 24.6 µM -0.952323644024296 0.189819661982169 no 2792 0.170466435130886 4053 2995952 SGTC_2318 6029776 164 µM -0.952810378303658 0.189691689015344 no 2793 0.170343077481209 4065 818325 SGTC_2108 5365811 200 µM -0.953595362723773 0.189485411475513 no 2794 0.170144251996468 4063 780283 SGTC_1561 5-methoxyflavone 52.9 µM -0.955976553852877 0.188860528978255 no 2795 0.169542040053111 3951 94525 SGTC_1611 st001856 99.4 µM -0.95609997881533 0.188828173916857 no 2796 0.169510862753191 4014 647478 SGTC_2709 st078560 56 µM -0.958429035839239 0.18821826710885 no 2797 0.168923229794389 4032 17250903 SGTC_2915 7971052 15.16 µM -0.962720367144634 0.187097689980031 no 2798 0.167843936422934 3953 5741558 SGTC_3171 9103192 49.47 µM -0.96506099837599 0.186488233769935 no 2799 0.167257130138774 4076 13018434 SGTC_2372 9071633 200 µM -0.965169619427046 0.186459980783534 no 2800 0.167229930521129 4072 21321366 SGTC_2863 9028737 58.44 µM -0.965374137012752 0.186406791729398 no 2801 0.167178725349634 4017 6460917 SGTC_216 k038-0035 28.382 µM -0.965385345856774 0.18640387690795 no 2802 0.167175919277873 3978 4444231 YPR107C YTH1 SGTC_2962 9082311 13.18 µM -0.96628904944272 0.186168964798441 no 2803 0.166949782023921 4046 16459453 SGTC_841 0251-0215 91.2 µM -0.966441069546631 0.186129466156666 no 2804 0.166911760838049 4075 3888614 SGTC_1416 3966-0321 25.3 µM -0.96740464459089 0.185879225976082 no 2805 0.166670894556665 4075 582530 YLR208W SEC13 SGTC_1342 1486-1464 234 µM -0.969873403230936 0.185239042667853 no 2806 0.166054799416329 4098 3253938 SGTC_2877 9040724 71.43 µM -0.970746248838466 0.185013029726599 no 2807 0.165837327532349 4051 6463895 SGTC_2048 5246248 200 µM -0.970774349707794 0.185005756190128 no 2808 0.165830329183796 4070 677046 SGTC_1054 3429-0080 167 µM -0.971632162101433 0.184783808350499 no 2809 0.165616788151474 4105 1162877 SGTC_1125 tnp00248 1.32998 µM -0.973390528566452 0.184329371442003 no 2810 0.165179622226708 4156 24207736 SGTC_2111 5486399 200 µM -0.974942218942672 0.18392892655521 no 2811 0.164794461168128 4028 689674 SGTC_1494 4358-1428 177 µM -0.976000171546058 0.183656211467477 no 2812 0.164532189661701 4091 1564571 SGTC_1019 4262-0212 3.4 µM -0.978005189935292 0.183140056941384 no 2813 0.16403587860953 4079 4677213 SGTC_1785 bathophenanthroline 24 µM -0.978925400500343 0.182903469166958 no 2814 0.163808420334018 3995 72812 An iron chelator. SGTC_1477 0139-0234 16 µM -0.980147077082261 0.182589668803005 no 2815 0.163506761924012 4083 620880 SGTC_760 0568-0725 82.9 µM -0.98109367799556 0.182346755821572 no 2816 0.163273273877009 4094 3916171 SGTC_1146 3579-1023 7 µM -0.981316265556459 0.182289665618359 no 2817 0.163218402029305 4107 X1146 SGTC_1218 1348-1416 30.7 µM -0.983191043215579 0.181809258006757 no 2818 0.162756711096577 4023 6787668 SGTC_1208 2323-2347 50.3 µM -0.984519896328997 0.181469222426636 no 2819 0.162429976829963 4091 5412760 SGTC_1571 st070080 73.4 µM -0.989617600321652 0.180168485058742 no 2820 0.161180531992219 4116 4315245 SGTC_2546 rhodinyl acetate 100 µM -0.990453382155758 0.1799557855458 no 2821 0.160976282153462 4024 6708682 SGTC_3256 9138902 49.47 µM -0.990818531571447 0.179862907578422 no 2822 0.160887099344618 4146 17228773 SGTC_804 1595-0054 20.9 µM -0.991123579254677 0.179785339938067 no 2823 0.160812620303894 4017 761523 Stimulates phospholipase C. SGTC_2339 9000433 200 µM -0.992622119124332 0.179404595903629 no 2824 0.160447070664019 4103 2988954 SGTC_844 0330-0132 15.3 µM -0.993536090132882 0.179172626253162 no 2825 0.16022438587621 4139 2828079 SGTC_1896 st058441 89 µM -0.993987775968706 0.179058056194916 no 2826 0.160114409348169 4087 688759 SGTC_809 3998-0021 90 µM -0.994449629227641 0.178940954842778 no 2827 0.160002008298998 4031 715485 SGTC_2581 avocatin a 64 µM -0.996235973101705 0.178488487146345 no 2828 0.159567752351428 4060 6710728 A skin care supplement. SGTC_2341 7987486 176.74 µM -0.996590462598648 0.17839878334866 no 2829 0.159481668612228 4126 1258686 SGTC_1810 st050138 53 µM -0.996947277148447 0.178308519883494 no 2830 0.159395050966574 4090 3444541 SGTC_1104 tacrolimus 29.8 µM -0.99730098629121 0.178219070403288 no 2831 0.159309217572033 4123 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_794 k038-0031 316 µM -0.998085756348417 0.178020710962739 no 2832 0.159118888184608 4073 6624242 SGTC_1200 1643-0193 18.4 µM -0.998148807694873 0.178004780070823 no 2833 0.159103602880821 4102 5403974 SGTC_975 1335-0046 28.5 µM -0.998728646552685 0.177858317017788 no 2834 0.158963079799602 4103 16486740 SGTC_1222 0366-0074 1.18 µM -1.00127135155089 0.177216946193159 no 2835 0.158347819628365 4104 286520 SGTC_2857 9024691 58.44 µM -1.00177207979035 0.177090815079577 no 2836 0.158226842426796 4190 16478292 SGTC_2946 9065502 71.43 µM -1.0021025197492 0.177007609861097 no 2837 0.158147040530631 3897 16489101 SGTC_2536 dehydroabietamide 32.04 µM -1.00211921416205 0.177003406841474 no 2838 0.158143009498417 4187 3983547 SGTC_2739 tacrine 100.86 µM -1.0029453807736 0.176795488221591 no 2839 0.157943607590596 4137 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_215 1287-0124 461.5 µM -1.00384040828744 0.176570413907205 no 2840 0.157727771932459 4113 5560863 SGTC_1752 st044819 83.042 µM -1.00450849185458 0.176402527798992 no 2841 0.157566790091413 4096 441209 YML126C ERG13 SGTC_1124 fisetin 1.16336 µM -1.00511603200136 0.176249943659448 no 2842 0.157420490592296 4115 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3186 9110464 49.47 µM -1.00753046549191 0.175644382840401 no 2843 0.156839962502765 4107 17018021 SGTC_2300 7976697 71.57 µM -1.00775798042589 0.175587388171818 no 2844 0.156785331370574 3987 2236109 SGTC_3277 9138724 49.47 µM -1.00788852574299 0.175554690612669 no 2845 0.156753990342634 4040 15943418 SGTC_620 0109-0052 432 µM -1.0086445808388 0.175365398122673 no 2846 0.156572559418583 4099 493037 SGTC_972 1319-0219 195 µM -1.00919770540085 0.175226995072346 no 2847 0.156439913441275 4084 23903702 SGTC_2601 securinine 100 µM -1.00952620261587 0.175144831163114 no 2848 0.156361170861374 4055 442872 A GABA receptor antagonist. SGTC_1568 digitonin 820 nM -1.01258416834955 0.174381143943612 no 2849 0.155629412492449 4106 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_79 0052-0007 94.094 µM -1.0127968824701 0.174328100165549 no 2850 0.155578595056456 4092 2801472 SGTC_2647 atorvastatin 60.16 µM -1.01284295408805 0.174316612797709 no 2851 0.155567589982106 4078 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3195 9113082 49.47 µM -1.01309250287429 0.174254399362274 no 2852 0.155507989474583 4080 17018038 SGTC_2385 9074692 200 µM -1.01494695964584 0.17379251853164 no 2853 0.155065555806855 4110 17046906 SGTC_2552 juarezic acid 87.02 µM -1.01711867729361 0.173252609927147 no 2854 0.154548488111242 4086 1549512 SGTC_1399 3562-5772 25 µM -1.01780740870015 0.17308160839047 no 2855 0.154384745244822 4060 23847490 SGTC_3100 9120536 49.47 µM -1.01789859984459 0.173058975078307 no 2856 0.154363073552893 3932 16421196 SGTC_3340 9146634 11.102 µM -1.01950857055749 0.172659696677476 no 2857 0.153980793202613 4127 4907387 SGTC_1140 3229-1848 2.98 µM -1.01998743308386 0.172541050497713 no 2858 0.15386721040919 4138 2849525 SGTC_1587 estradiol valerate 56.1 µM -1.02069100447034 0.172366823284034 no 2859 0.153700428879306 4160 13791 A steroid. SGTC_1998 st075797 76.8 µM -1.02180500580003 0.172091189851169 no 2860 0.153436599833632 4097 24208315 SGTC_2860 9025725 38.96 µM -1.02352833621183 0.171665346838568 no 2861 0.15302905461356 4141 40546248 SGTC_3244 9134489 49.47 µM -1.02379164491802 0.171600341359735 no 2862 0.152966848784484 4130 16584271 SGTC_122 0236-0016 402.397 µM -1.02495686167364 0.171312862249226 no 2863 0.152691771368916 4108 6808838 SGTC_1555 citronellol 128 µM -1.02531651849605 0.171224190914845 no 2864 0.152606932045394 4075 8842 A terpine precursor. SGTC_3295 9122362 53.5725 µM -1.03060546323684 0.169923621891543 no 2865 0.15136293654459 4157 4730473 SGTC_2935 9038016 29.96 µM -1.03093732743813 0.169842227095965 no 2866 0.151285105336321 4113 6463195 SGTC_2229 7354935 190 µM -1.03138696523463 0.169731986405521 no 2867 0.151179695480202 4044 318112 SGTC_766 1391-0721 126 µM -1.03161502173286 0.169676089821368 no 2868 0.151126250232914 4159 1020919 YIL115C NUP159 SGTC_178 4092-0806 87.505 µM -1.03717589383791 0.168316776690748 no 2869 0.149826945208651 4013 2169044 SGTC_2968 9090663 33.37 µM -1.03726845784009 0.168294209546958 no 2870 0.149805380742672 4085 25236811 SGTC_3038 9091290 49.47 µM -1.03801623311546 0.168111972982769 no 2871 0.149631248826854 4161 25236843 SGTC_1697 st025554 27.742 µM -1.03933030156488 0.167792035696824 no 2872 0.149325573448311 4117 1269519 SGTC_547 1120-0019 610 nM -1.04211953786639 0.167114238277177 no 2873 0.148678130664585 4091 3676939 SGTC_2458 5808907 16.39 µM -1.04219743047191 0.167095335383431 no 2874 0.14866007706046 4276 2731747 SGTC_2902 5787006 60.46 µM -1.0430588547866 0.166886377792779 no 2875 0.148460517658388 4093 591003 SGTC_1417 3966-0327 90.4 µM -1.0456956877701 0.166247803566192 no 2876 0.147850777193493 4229 651118 SGTC_2286 7945697 125 µM -1.04646118441447 0.166062715619025 no 2877 0.147674078452644 4175 1245733 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.04670497512626 0.166003797899785 no 2878 0.147617834219481 4098 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_128 0906-2981 13.371 µM -1.04943276999223 0.165345483843377 no 2879 0.146989491256447 4132 6740226 SGTC_667 1498-1044 59 µM -1.04984362328846 0.165246476881021 no 2880 0.146895007540381 4155 6739982 SGTC_2315 7733312 200 µM -1.05006224429866 0.16519380948025 no 2881 0.146844747990861 4038 726316 SGTC_2103 5378138 10 µM -1.05333058282048 0.164407738353508 no 2882 0.146094753486999 4216 244142 SGTC_1406 3909-7906 11.9 µM -1.05394802163809 0.164259510328283 no 2883 0.145953357614649 4161 X1406 SGTC_1751 st044839 27.194 µM -1.0559193141544 0.163786843972344 no 2884 0.145502539633085 4168 5291326 SGTC_2242 6630449 61.2675 µM -1.05793644462823 0.163304101586156 no 2885 0.145042209257971 4206 691249 YDR170C SEC7 SGTC_1773 st048542 73.5835 µM -1.05885995071516 0.163083395666063 no 2886 0.144831782954528 4096 3237138 SGTC_3247 9135149 49.47 µM -1.05888992890031 0.163076234520855 no 2887 0.144824955694995 4161 8934436 YOR116C RPO31 SGTC_2887 9044784 58.44 µM -1.05917637770375 0.163007818355139 no 2888 0.144759730509108 4127 6465546 SGTC_2167 5876490 200 µM -1.05984267428157 0.162848750563409 no 2889 0.144608089471275 4277 686534 SGTC_1567 st069303 68.4 µM -1.06128775797104 0.162504106615496 no 2890 0.1442795737468 4216 5581319 SGTC_779 1360-0071 233 µM -1.06387275927873 0.161888783802883 no 2891 0.143693172432106 4214 7566 SGTC_1213 1315-0166 115 µM -1.06425779038854 0.161797262678387 no 2892 0.14360596686701 4233 768401 SGTC_3019 9081971 49.47 µM -1.06604576179305 0.161372707345698 no 2893 0.143201477967241 4179 16451803 SGTC_1408 3909-7976 48.8 µM -1.07032076070061 0.160360553286155 no 2894 0.142237476361612 4202 24152374 SGTC_3141 9094609 49.47 µM -1.07075282439952 0.160258488677127 no 2895 0.142140291983028 4125 25236309 YDL196W YDL196W SGTC_751 0833-0568 350 µM -1.07156029048751 0.16006785817285 no 2896 0.14195878859081 4181 6954252 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.07410659691266 0.15946768521684 no 2897 0.141387454100226 4196 6728940 SGTC_347 4534-1311 26.2 µM -1.07413120341264 0.159461892578388 no 2898 0.141381940562923 4167 2862016 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.07521521459981 0.159206841225106 no 2899 0.141139192598047 4260 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_303 1348-1668 34.2 µM -1.07567267230495 0.159099288594756 no 2900 0.141036836687067 4176 5380509 SGTC_544 k015-0020 52.4 µM -1.07571019052188 0.159090469819794 no 2901 0.14102844424087 4176 3008304 SGTC_2055 5235184 200 µM -1.07599144285103 0.159024370773238 no 2902 0.140965541721761 4222 2836034 SGTC_994 3910-0338 138 µM -1.07684429014901 0.158824047280673 no 2903 0.140774917460156 4235 3479481 SGTC_2141 5621638 7.665 µM -1.07767976819887 0.158627964069598 no 2904 0.14058834516463 4189 2856238 SGTC_2178 5812956 200 µM -1.08148132500912 0.157737759787464 no 2905 0.139741531702429 4143 5403383 SGTC_1431 4049-0260 9.09 µM -1.0829527265366 0.157394086682706 no 2906 0.139414703295925 4158 3854841 SGTC_2117 5521686 200 µM -1.08655897719304 0.156553862881024 no 2907 0.138615881532955 4132 803312 SGTC_1312 1218-2183 165 µM -1.0880637496594 0.15620413931091 no 2908 0.138283482729228 4227 6744073 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.08872500682608 0.156050619709137 no 2909 0.138137585402889 4179 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.08884812697722 0.156022046720999 no 2910 0.138110432224971 4313 16725076 SGTC_1496 4469-0713 57.4 µM -1.08909694506338 0.155964313034092 no 2911 0.138055568470145 4167 746691 SGTC_635 k038-0028 24.7 µM -1.09069368466023 0.155594153980948 no 2912 0.137703845212928 4187 4035102 SGTC_106 0092-0003 11.579 µM -1.09244649472216 0.155188482142057 no 2913 0.137318448051876 4103 1072148 SGTC_1851 st056236 18.9 µM -1.0933015855953 0.154990832807747 no 2914 0.137130703478541 4195 5393171 SGTC_1715 st032160 10.2275 µM -1.09551225966439 0.154480618982293 no 2915 0.13664613875654 4124 5289825 SGTC_3260 9137109 49.47 µM -1.0985156920725 0.15378922087593 no 2916 0.135989684665586 4131 17478346 SGTC_2075 5212009 200 µM -1.09950796499463 0.153561247856472 no 2917 0.135773280852306 4107 780898 SGTC_984 1492-0255 2.91 µM -1.09956264820438 0.153548690991496 no 2918 0.135761361906337 4164 1585198 SGTC_1073 triclabendazole 3.09 µM -1.09995613504252 0.153458354951252 no 2919 0.135675617253412 4243 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2360 9040895 200 µM -1.10098055512577 0.153223335479368 no 2920 0.135452560074609 4216 4914414 SGTC_2020 4017018 200 µM -1.10266286125909 0.152837903416383 no 2921 0.13508680029311 4247 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2438 5259590 200 µM -1.10286699614701 0.15279117798545 no 2922 0.135042464283102 4204 1201127 SGTC_683 panaxydol 45 µM -1.10293199536743 0.152776301985372 no 2923 0.135028349212069 4180 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3178 9107506 49.47 µM -1.10339593555967 0.152670150542905 no 2924 0.134927630485208 4203 8897194 SGTC_3242 9133940 49.47 µM -1.10389021384562 0.152557111461671 no 2925 0.134820382245862 4210 17248444 SGTC_1344 1488-0097 29.1 µM -1.10889289539452 0.151416148007949 no 2926 0.133738194543219 4240 747966 SGTC_2952 9073731 13.78 µM -1.11078033668335 0.150987156628375 no 2927 0.133331456146276 4260 16457353 SGTC_2045 5106652 78.05 µM -1.11267946580594 0.150556325934332 no 2928 0.132923058828293 4182 673349 SGTC_2002 4023503 131 µM -1.11466987439903 0.150105667495991 no 2929 0.132495957584149 4220 4736863 YCR052W RSC6 SGTC_2924 9010168 62.78 µM -1.11469338263425 0.150100350256856 no 2930 0.132490918850981 4279 2993929 SGTC_1347 1493-0251 600 nM -1.1159927608196 0.149806644079574 no 2931 0.132212616668639 4259 3986378 SGTC_3333 9141820 12.094 µM -1.11797975899953 0.149358252847592 no 2932 0.131787819127476 4198 1939433 SGTC_420 mitomycin C 81.9 mM -1.12426391977613 0.147946055582125 no 2933 0.130450539923137 4203 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_309 k408-0051 1.48 µM -1.12443200171768 0.147908406793672 no 2934 0.130414901159684 4140 3640463 SGTC_43 0570-0105 72.5 µM -1.12566541261178 0.147632330478337 no 2935 0.130153584511872 4206 1114046 YDL195W SEC31 SGTC_2102 5377816 72.7585 µM -1.12705224488395 0.147322326087118 no 2936 0.129860196247176 4275 1379702 SGTC_2934 9036370 36.88 µM -1.12740107837751 0.147244418603171 no 2937 0.129786471670896 4202 6462800 SGTC_2487 5918373 44.05 µM -1.12905905045337 0.146874509416859 no 2938 0.12943646211649 4292 2876279 SGTC_1680 diphenhydramine 100 µM -1.12909162566264 0.146867247830206 no 2939 0.129429591818681 4206 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_587 k089-0003 57 µM -1.12925694878273 0.146830398113736 no 2940 0.129394728123184 4110 9659696 SGTC_1161 k007-0610 110 µM -1.12939662996508 0.146799268694331 no 2941 0.129365276927044 4200 5843850 SGTC_3289 9119912 71.43 µM -1.13068213309808 0.146512988691886 no 2942 0.129094452037536 4260 17014829 SGTC_2612 dictamnine 15.46 µM -1.1320134316423 0.146216905360605 no 2943 0.128814393770223 4165 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1117 retinoic acid 1.10837 µM -1.13506626903706 0.14553946673641 no 2944 0.128173776618175 4266 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2132 5317594 122.667 µM -1.13554325711993 0.145433811850254 no 2945 0.128073884126535 4183 794577 SGTC_1994 st072947 40.9 µM -1.13558060923536 0.145425540376704 no 2946 0.128066064001349 4278 5286565 YDL195W SEC31 SGTC_2770 toltrazuril 17.5 µM -1.13625158902204 0.14527700853612 no 2947 0.12792564261668 4176 68591 Kills coccidiodes. SGTC_939 1165-0479 45.3 µM -1.13798362368584 0.144894067582109 no 2948 0.127563660293099 4218 1377347 SGTC_1143 3454-2408 5.08 µM -1.13919621295502 0.144626377244605 no 2949 0.127310662383037 4228 X1143 SGTC_359 0081-0058 15.9 µM -1.13923252802598 0.144618365496936 no 2950 0.12730309089507 4330 3494159 SGTC_956 1185-0240 191 µM -1.13936729112498 0.144588636984508 no 2951 0.127274996285162 4209 1416193 SGTC_572 0960-0087 17.7 µM -1.14482223618088 0.143388740913284 no 2952 0.126141401094798 4217 6796365 SGTC_433 pimozide 108 µM -1.14520978725239 0.143303749856288 no 2953 0.12606113251391 4147 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2065 5221596 34.26 µM -1.14655087288372 0.143009908536271 no 2954 0.125783645159515 4217 788581 SGTC_580 1123-0028 41 µM -1.14762949127149 0.142773871235162 no 2955 0.125560774908133 4279 1677248 YPR107C YTH1 SGTC_2549 cedrol 20.94 µM -1.14897705801033 0.14247934938887 no 2956 0.125282720414406 4180 6708665 A sedative which affects the nervous system. SGTC_1698 5-fluorocytosine 1.055 µM -1.14961114716544 0.142340906236202 no 2957 0.125152032444504 4240 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1588 farnesol 29.9 µM -1.15032962045433 0.142184149183712 no 2958 0.125004067695865 4249 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2985 9022375 71.43 µM -1.15236246576713 0.141741254533105 no 2959 0.124586078999505 4307 4939335 SGTC_2978 9011784 42.97 µM -1.15249837766804 0.141711676858899 no 2960 0.124558168012327 4220 2994934 SGTC_1264 0783-0040 158 µM -1.15315990529216 0.141567772353437 no 2961 0.124422378538395 4141 2855798 SGTC_3076 9116187 49.47 µM -1.15559913994308 0.141038012582718 no 2962 0.123922579992234 4229 27241210 SGTC_3055 9094636 49.47 µM -1.15673412522991 0.140791972236781 no 2963 0.123690501461158 4284 25236176 SGTC_703 3875-0075 71.8 µM -1.15879431475148 0.140346112028245 no 2964 0.123270017729419 4305 2850814 SGTC_230 MPP+ 141.667 µM -1.15916203737616 0.140266631524626 no 2965 0.123195071180445 4215 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2371 9071574 200 µM -1.15998074737137 0.140089783282126 no 2966 0.123028322379447 4249 45596039 SGTC_2266 7929956 200 µM -1.16081284548062 0.139910198379944 no 2967 0.12285900897396 4185 2967153 SGTC_1192 1488-0095 21.4 µM -1.16108537736484 0.139851414090498 no 2968 0.122803590352661 4299 915875 SGTC_497 capsazepine 133 µM -1.16463688309837 0.139086900018577 no 2969 0.12208300376122 4208 2733484 A calcium channel blocker. SGTC_99 0109-0120 622.8 µM -1.16589543491658 0.1388166620965 no 2970 0.121828362466351 4214 759414 SGTC_540 1187-0821 17.3 µM -1.16630156746067 0.138729533138871 no 2971 0.121746269841459 4192 847520 SGTC_3072 9116419 49.47 µM -1.16679903983325 0.138622859512718 no 2972 0.12164576743344 4298 17170162 SGTC_2685 mycophenolic acid 18.85 µM -1.16819355262213 0.138324130316392 no 2973 0.121364350287596 4239 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3324 9138759 60.749 µM -1.16832567622809 0.1382958498878 no 2974 0.121337711080091 4297 45595710 SGTC_1952 st077036 64.1 µM -1.17008359548397 0.137919950724235 no 2975 0.120983664700105 4271 2937007 SGTC_374 0880-0231 82.3 µM -1.17120198561437 0.137681166357334 no 2976 0.120758798679412 4140 6833587 SGTC_2996 9066192 71.4286 µM -1.17136115094354 0.137647206358062 no 2977 0.120726820471145 4293 6472854 SGTC_3060 1327-0027 12.5 µM -1.17174808311273 0.13756467317594 no 2978 0.120649106056019 4174 16000455 YPR107C YTH1 SGTC_1404 3909-7820 48.3 µM -1.17754885199346 0.136331409709495 no 2979 0.11948825551375 4238 23741373 SGTC_2063 5246145 200 µM -1.17924773646754 0.13597165754334 no 2980 0.119149771330066 4299 711240 SGTC_1191 1487-1166 10.6 µM -1.17949636883218 0.135919062251435 no 2981 0.119100290881814 4309 3955771 SGTC_3022 9087993 49.47 µM -1.18352321208639 0.135069169827707 no 2982 0.118300926348842 4340 17173644 SGTC_464 bw-b 70c 158 µM -1.18358220110547 0.135056746942148 no 2983 0.118289244756818 4285 5353454 SGTC_2994 9053520 71.4286 µM -1.18452417031298 0.134858477607494 no 2984 0.118102817131832 4310 4647384 SGTC_2718 lomofungin 53.02 µM -1.18555769224682 0.134641167744426 no 2985 0.117898509249717 4248 5351222 A RNA synthesis inhibitor. SGTC_3085 9117376 49.47 µM -1.18571287295905 0.134608559979523 no 2986 0.117867854541017 4362 16480349 SGTC_902 1120-0002 2.07 µM -1.1885588105848 0.134011510789934 no 2987 0.117306662192797 4258 3280475 SGTC_2618 avocadyne 43.43 µM -1.18864732500756 0.133992970573903 no 2988 0.117289238370833 4195 3015189 SGTC_1383 3049-0032 20.7 µM -1.18888739377981 0.133942694682417 no 2989 0.11724199071769 4338 712864 SGTC_1182 1222-0449 220 µM -1.19317350455071 0.133047266531638 no 2990 0.116400714502824 4282 658318 SGTC_1310 1188-0297 994 nM -1.19320477004452 0.133040749909347 no 2991 0.116394593497429 4149 1588352 SGTC_2278 7948257 134.34 µM -1.19324913290178 0.133031503799313 no 2992 0.116385908746168 4284 1247028 SGTC_2575 plumbagin 510 nM -1.19342514814745 0.132994823047785 no 2993 0.116351455427825 4188 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2462 5162487 171.77 µM -1.19661867533927 0.132330515951297 no 2994 0.115727608985772 4242 2259986 SGTC_1257 0669-0121 16 µM -1.20045392345014 0.131535747315493 no 2995 0.114981548623142 4279 4307855 SGTC_911 3456-4043 236 µM -1.2019280951339 0.131231136894446 no 2996 0.114695694069664 4280 914281 SGTC_564 3555-0129 330 µM -1.20951707013505 0.129670726621181 no 2997 0.113232128515501 4174 563260 SGTC_2249 haloperidol 116.36 µM -1.20969328077777 0.129634648303386 no 2998 0.113198304561824 4259 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1972 st070201 17.4 µM -1.2101188569488 0.12954754221819 no 2999 0.113116644171161 4302 2829099 SGTC_2115 tiliquinol 12.7705 µM -1.21204126496631 0.129154572876166 no 3000 0.112748292563863 4271 71208 A bioactive hydroxyquinoline. SGTC_223 busulfan 5 mM -1.21288341611307 0.128982684985443 no 3001 0.112587198486719 4284 2478 A DNA alkylator. SGTC_1322 1348-1070 12 µM -1.21695784965774 0.12815331047156 no 3002 0.111810126702459 4298 6758089 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.21882469158376 0.127774543994825 no 3003 0.111455368855306 4172 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2274 7947094 46.08 µM -1.21893624677513 0.127751935049185 no 3004 0.111434195445791 4246 2971028 SGTC_135 0933-0004 26.348 µM -1.21908878562234 0.127721024426495 no 3005 0.111405247912072 4266 21230617 YGL099W LSG1 SGTC_2928 9011484 9.79 µM -1.21913759582227 0.127711134577326 no 3006 0.111395986261437 4313 2994751 SGTC_1674 st016616 23.6 µM -1.2240628559173 0.126715921586548 no 3007 0.110464258405611 4250 625830 SGTC_484 loperamide 105 µM -1.22509579752419 0.12650788920068 no 3008 0.110269564197316 4371 3955 An opioid-receptor agonist. SGTC_1357 1503-1303 39.5 µM -1.2306641157005 0.125390539613843 no 3009 0.109224257226877 4297 292895 SGTC_468 gf-109203x 121 µM -1.23111248976699 0.125300868617399 no 3010 0.109140397430126 4324 2396 A protein kinase C inhibitor. SGTC_3306 9127676 59.7925 µM -1.23373088196284 0.124778106590105 no 3011 0.108651601172393 4277 41905287 SGTC_2730 imipramine 71.33 µM -1.23619771458211 0.124286999521561 no 3012 0.108192540007841 4288 3696 A tricyclic antidepressant. SGTC_2180 6301957 200 µM -1.23682995328944 0.124161348814154 no 3013 0.108075109672252 4335 845462 SGTC_1450 4112-4260 37.6 µM -1.23703704325459 0.124120211218116 no 3014 0.108036665291489 4321 1633175 SGTC_1659 st012954 42.1 µM -1.23769404498345 0.123989763563812 no 3015 0.107914764030439 4267 24207262 SGTC_1877 wortmannin 25 µM -1.23962055844474 0.123607807666651 no 3016 0.107557886473442 4324 312145 A covalent inhibitor of PI 3-kinase. SGTC_280 3448-3607 3.04 µM -1.24010970267262 0.123510959879531 no 3017 0.107467410340486 4281 626179 SGTC_1794 st048918 76.9 µM -1.24296043344228 0.122947588808545 no 3018 0.106941207041354 4258 672303 SGTC_3311 9131146 2.8755 µM -1.24422410825427 0.122698434324212 no 3019 0.106708546634821 4274 4900406 YPR165W RHO1 SGTC_2714 st079313 56.9 µM -1.24645182624847 0.122260065659586 no 3020 0.106299282287235 4298 2939799 SGTC_1219 1469-0211 33.1 µM -1.2471425576666 0.122124367621231 no 3021 0.106172615372646 4336 6822282 SGTC_213 1246-0773 967 nM -1.24769919882869 0.122015089340314 no 3022 0.106070617408952 4340 6251622 SGTC_27 0485-0001 32.618 µM -1.24837969858718 0.121881588794114 no 3023 0.105946020012363 4306 2054479 SGTC_101 0490-5701 117.494 µM -1.25345477536172 0.120889195214423 no 3024 0.105020123900791 4176 4661669 SGTC_431 k089-0097 107 µM -1.25386469015115 0.120809288331854 no 3025 0.104945595563791 4087 5499420 SGTC_1720 st037298 9.481 µM -1.25646885180693 0.120302513406943 no 3026 0.104473016105209 4324 597396 SGTC_12 0849-0099 9.267 µM -1.26139122046151 0.119348705638014 no 3027 0.103583964958382 4264 6071388 SGTC_3199 9111318 49.47 µM -1.2665727587351 0.118350457168456 no 3028 0.102654049055043 4264 8548020 SGTC_2751 anetholtrithion 17.25 µM -1.26752814258196 0.118167044219537 no 3029 0.102483253670028 4316 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1366 1683-0113 21.9 µM -1.26804394476816 0.118068105000378 no 3030 0.102391128879275 4330 708623 SGTC_898 1000-0849 28.3 µM -1.27388205166517 0.116952344739563 no 3031 0.101352610094987 4357 6751807 SGTC_1469 k284-2957 126 µM -1.2751819427332 0.116704934212872 no 3032 0.101122425551329 4345 23884841 SGTC_346 4513-0042 7.16 µM -1.28208029968669 0.115398168011117 no 3033 0.0999072394751684 4305 2827372 SGTC_3347 9188721 44.724 µM -1.29068715723071 0.11378238310912 no 3034 0.0984060898763964 4363 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1513 0337-0559 19 µM -1.29138728772917 0.113651658756708 no 3035 0.0982847082317919 4337 775073 SGTC_1690 st023502 41.2 µM -1.29824625150407 0.112376652296513 no 3036 0.0971013646959181 4372 24207482 SGTC_2506 ethyl hematommate 54.16 µM -1.29845048193253 0.112338845410746 no 3037 0.0970662908355227 4405 3940691 An allergen. SGTC_217 ketoconazole 989 nM -1.29989081953153 0.112072469943123 no 3038 0.0968191960166018 4183 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2431 5490079 200 µM -1.30141528254208 0.111791028551179 no 3039 0.0965581726691951 4401 5722345 SGTC_1047 2043-3044 82 µM -1.30307591492891 0.111485023672462 no 3040 0.0962744226853771 4350 669592 SGTC_981 1488-1094 54.9 µM -1.3037933576818 0.111353006026764 no 3041 0.0961520239897035 4340 3449522 SGTC_1434 4073-0095 163 µM -1.30681061501909 0.110799021228714 no 3042 0.0956385195746678 4361 24133745 SGTC_729 4092-0585 94.1 µM -1.30794125029634 0.110591939943273 no 3043 0.0954466183977597 4380 2169061 SGTC_2482 5981709 142.65 µM -1.30952057426239 0.11030314377366 no 3044 0.095179036573307 4302 877755 SGTC_1650 st011916 45.8 µM -1.30972881640691 0.110265104878485 no 3045 0.0951437957696626 4306 242528 SGTC_2767 sibutramine 71.45 µM -1.30989823953252 0.110234163864967 no 3046 0.0951151313959856 4392 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_255 tunicamycin 200.472 nM -1.31026927050607 0.110166425833067 no 3047 0.0950523795940259 4300 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_139 0099-0334 718.624 µM -1.31328608252676 0.10961676349093 no 3048 0.0945432832221518 4394 97690 SGTC_1015 4130-4525 82 µM -1.31334744521225 0.109605603696264 no 3049 0.0945329489793191 4384 1363237 SGTC_2634 4'-methoxyflavone 100 µM -1.31464714546271 0.109369423828497 no 3050 0.0943142588021249 4379 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3103 9120822 49.47 µM -1.31588148883809 0.109145459191995 no 3051 0.0941069113644836 4382 17141819 SGTC_1216 1165-0504 9.65 µM -1.31888126456538 0.108602541007338 no 3052 0.0936044053022481 4396 6304004 SGTC_586 0957-0265 8.15 µM -1.32030236166497 0.108346021149509 no 3053 0.0933670437038122 4247 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.32240823059858 0.107966696511406 no 3054 0.0930161248007602 4384 616764 SGTC_1545 lovastatin 49.4 µM -1.32358853045658 0.107754510867044 no 3055 0.0928198682069689 4413 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_551 k048-0028 34.9 µM -1.32691331437123 0.107158420924266 no 3056 0.09226867975192 4353 6836383 SGTC_111 0083-0039 52.457 µM -1.32778866219292 0.107001878785239 no 3057 0.0921239667497072 4334 759313 SGTC_470 aa-861 153 µM -1.32865862219268 0.106846463674372 no 3058 0.0919803110155258 4341 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_176 1486-1328 72.834 µM -1.32977274257166 0.106647668160663 no 3059 0.0917965796325004 4431 22310231 SGTC_845 0330-0138 4.51 µM -1.33049469167085 0.10651899145667 no 3060 0.0916776670921977 4334 9039800 SGTC_367 0335-0881 7.1 µM -1.33157559362755 0.106326546327903 no 3061 0.0914998446839909 4330 23828853 SGTC_2038 4100038 30.985 µM -1.33268511302379 0.106129267395164 no 3062 0.0913175803365804 4361 3596803 SGTC_1403 3909-7815 62.9 µM -1.33615800753232 0.1055134762963 no 3063 0.0907488166203656 4362 6615483 SGTC_754 3474-0146 171 µM -1.33667448817649 0.105422118473919 no 3064 0.0906644564736609 4381 24762078 SGTC_362 0310-0100 9.03 µM -1.3372526879004 0.105319911351194 no 3065 0.0905700844176991 4432 790235 SGTC_3026 9090633 49.47 µM -1.33772322844937 0.105236787832678 no 3066 0.0904933380090151 4389 25236842 SGTC_2299 7976368 114.88 µM -1.33777041237711 0.105228455157505 no 3067 0.0904856448498827 4419 2979718 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.34101010807743 0.104657466534864 no 3068 0.0899585853927108 4392 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1427 4048-4900 550 nM -1.3431249529792 0.104285942798984 no 3069 0.0896157584621694 4392 24132586 SGTC_3329 9141233 27.5565 µM -1.34328270815383 0.104258267640955 no 3070 0.0895902245487648 4358 4909101 YNL103W MET4 SGTC_3259 9138485 49.47 µM -1.35145673406348 0.102831565066958 no 3071 0.0882745852463202 4408 17646153 SGTC_296 1222-0039 74.9 µM -1.35222338425172 0.102698484418071 no 3072 0.0881519326015897 4414 5984176 SGTC_3345 9148410 3.559 µM -1.3524997394371 0.102650543405616 no 3073 0.0881077510412844 4349 4903596 SGTC_2806 7952793 58.44 µM -1.35427445528998 0.102343060280051 no 3074 0.0878244163469062 4432 2972490 SGTC_650 1328-0195 38 µM -1.35464867207487 0.102278309952983 no 3075 0.0877647592166577 4418 2780821 SGTC_1884 5633444 25 µM -1.35651353517949 0.101956078891661 no 3076 0.0874679158986089 4354 5724239 SGTC_377 3970-0964 33.1 µM -1.35905383422054 0.101518328295608 no 3077 0.0870647651684853 4396 16481235 SGTC_1384 3089-0840 101 µM -1.36278410563533 0.100878001989748 no 3078 0.0864752809109605 4415 1069836 SGTC_449 xestospongin c 11.1929 µM -1.36885483257169 0.0998422249427336 no 3079 0.0855223284484803 4430 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2662 daunorubicin 22.37 µM -1.37205022716025 0.0993001628603878 no 3080 0.0850239012023553 4312 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_909 3448-9333 149 µM -1.37425736834532 0.0989270050848128 no 3081 0.0846808981500073 4347 3344074 SGTC_2839 9003951 25.97 µM -1.37659750725947 0.0985324832161191 no 3082 0.0843183610102455 4461 2990634 SGTC_676 falcarinol 140 µM -1.37940609955904 0.0980605075569259 no 3083 0.0838847898424678 4445 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1930 st074634 34.3 µM -1.382883986303 0.0974783572974688 no 3084 0.0833502206150221 4335 684253 YOR116C RPO31 SGTC_340 k038-0059 454 µM -1.38348039386613 0.0973787820445568 no 3085 0.0832588074725403 4392 23733424 SGTC_2955 9076254 12.21 µM -1.38488486605959 0.0971445884099541 no 3086 0.0830438376595218 4347 16459619 SGTC_847 0342-0274 5.54 µM -1.38679090244974 0.096827421189935 no 3087 0.0827527660080438 4415 18097 SGTC_414 piperonyl butoxide 100 µM -1.38772131055856 0.0966728763911109 no 3088 0.0826109621155643 4431 5794 A potent inhibitor of cytochrome P450. SGTC_2936 9038235 15.59 µM -1.38810698066433 0.0966088680660541 no 3089 0.0825522356204092 4350 4749415 SGTC_2541 muurolladie-3-one 83.07 µM -1.38881038766229 0.0964922062336421 no 3090 0.0824452078437339 4385 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_488 nitrendipine 139 µM -1.38996741516895 0.0963005354986895 no 3091 0.08226938617069 4452 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2567 aureobasidin a 60 nM -1.39068506063592 0.0961817925565602 no 3092 0.0821604748879044 4517 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2816 7982706 58.44 µM -1.39273382850657 0.0958433919538385 no 3093 0.0818501474801089 4426 2981853 SGTC_1355 1499-0035 1.68 µM -1.39286307175747 0.0958220738945904 no 3094 0.0818306006329908 4427 1548538 SGTC_1749 st037932 54.2 µM -1.39376119095302 0.095674029732723 no 3095 0.0816948655665851 4446 594497 SGTC_996 3970-0799 1.8 µM -1.39449247661812 0.095553610430769 no 3096 0.0815844699041395 4412 6615648 YGL040C HEM2 SGTC_837 0091-0265 12.5 µM -1.39457680536813 0.0955397313654547 no 3097 0.081571746783191 4422 759367 SGTC_1394 3474-0001 65.7 µM -1.397130071425 0.0951202097949768 no 3098 0.0811872301916726 4407 5017666 YIL048W NEO1 SGTC_1996 st072960 66.8 µM -1.40685493378618 0.0935347619789705 no 3099 0.0797352046320202 4467 1719405 SGTC_2499 avocadenofuran 51.48 µM -1.41204345042377 0.0926969017527913 no 3100 0.0789685839093476 4409 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2258 7960471 200 µM -1.41296696441856 0.0925483531673957 no 3101 0.0788327188781552 4444 2974708 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.41541749510236 0.0921550354503094 no 3102 0.078473061528618 4466 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1185 1319-0113 81.3 µM -1.41566994603218 0.0921145867113962 no 3103 0.0784360808214221 4506 4672763 SGTC_1503 4585-0012 61.3 µM -1.41650806819018 0.0919803935454096 no 3104 0.0783134018050575 4461 2922052 SGTC_987 1497-1013 404 µM -1.41850832863594 0.0916607135671329 no 3105 0.0780212044163188 4462 1676435 SGTC_660 4031-1742 102 µM -1.41938867902941 0.0915202778670394 no 3106 0.0778928655609078 4326 6738706 SGTC_796 1234-0020 70.7 µM -1.4217611341254 0.0911426118868852 no 3107 0.0775478029862589 4383 46495034 SGTC_617 3770-0098 35 µM -1.42255096516678 0.091017137181615 no 3108 0.0774331836372527 4366 5962639 SGTC_3064 1327-0027 10 µM -1.42321126452167 0.0909123386033456 no 3109 0.0773374605560649 4395 16000455 YPR107C YTH1 SGTC_3175 9106517 49.47 µM -1.42322407331161 0.090910306557936 no 3110 0.0773356045649461 4457 41468073 SGTC_2021 4019055 173 µM -1.42511234278776 0.0906111113078298 no 3111 0.0770623646701931 4235 44827708 YER133W GLC7 SGTC_1470 k295-0292 231 µM -1.43304850036474 0.0893616205337449 no 3112 0.0759219887049874 4520 5045612 SGTC_1277 0873-0036 22 µM -1.43317319489945 0.089342091073673 no 3113 0.0759041739839363 4524 5965735 SGTC_2569 tetrandrine 100 µM -1.43538154068795 0.0889967493215585 no 3114 0.0755892016204624 4469 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3348 9149464 3.537 µM -1.4363554383584 0.0888447670391095 no 3115 0.0754506131931652 4394 1951442 SGTC_2334 9017922 200 µM -1.43849283285979 0.0885118920454091 no 3116 0.0751471347925075 4479 3163164 SGTC_496 calpeptin 138 µM -1.44307337439682 0.0878016552791958 no 3117 0.0744999014120588 4457 73364 A calpain inhibitor. SGTC_2958 9077254 16.72 µM -1.44370479584284 0.0877040844368151 no 3118 0.0744110159141891 4490 16457351 SGTC_3222 9128301 49.47 µM -1.44877879743407 0.0869229557737486 no 3119 0.0736996833766961 4425 4911358 SGTC_3030 9087619 49.47 µM -1.44885035107952 0.0869119775704228 no 3120 0.0736896894549175 4479 25236973 SGTC_568 1193-0097 7.48 µM -1.45169826264559 0.0864758739563126 no 3121 0.073292761306527 4271 3646150 SGTC_1946 st076057 65.1 µM -1.4522321929993 0.086394295085996 no 3122 0.0732185270757336 4452 953009 SGTC_1321 1326-2144 215 µM -1.4616806238434 0.0849601797384119 no 3123 0.0719143746671664 4442 3513030 SGTC_706 4262-0057 46.9 µM -1.46615866159301 0.0842867532863048 no 3124 0.0713025337626167 4474 883298 SGTC_2237 6667747 47.222 µM -1.4669128174638 0.0841737353304909 no 3125 0.0711998866486042 4470 729940 YDL015C TSC13 SGTC_3024 9090631 49.47 µM -1.46777633968887 0.0840444674468887 no 3126 0.071082493202312 4438 25236383 SGTC_380 3970-0968 6 µM -1.46791661628763 0.0840234823468638 no 3127 0.0710634370309484 4372 2891601 SGTC_3294 9122953 26.2835 µM -1.46915637194303 0.0838381883710447 no 3128 0.0708951903215237 4462 16459826 SGTC_94 0334-0113 514.748 µM -1.46957472819687 0.0837757301195523 no 3129 0.0708384844779424 4494 6795178 SGTC_1993 st073995 70.8 µM -1.47355825580709 0.0831827615500296 no 3130 0.0703002839026748 4492 3098394 SGTC_2539 epi(13)torulosol 80 µM -1.47447245439918 0.0830471246993695 no 3131 0.0701772144687022 4443 6708597 SGTC_645 0845-0943 5.41 µM -1.47621536083806 0.0827889959644789 no 3132 0.0699430435761838 4505 1885106 SGTC_563 tetrahydrosecaminediol 614 µM -1.47843370976016 0.0824613267907437 no 3133 0.0696458640898565 4523 334274 A psychoactive constituent of the cannabis plant. SGTC_1157 4092-0394 27.6 µM -1.47861371334902 0.0824347816040879 no 3134 0.0696217927461692 4537 3659885 SGTC_103 0844-0104 51.839 µM -1.48447101622751 0.0815745100590319 no 3135 0.0688420034090084 4307 5375804 SGTC_2518 prenyletin 46.28 µM -1.48543792724035 0.0814331516228849 no 3136 0.0687139275048444 4503 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1132 3456-3614 2.5 µM -1.48821279239348 0.0810285036023187 no 3137 0.0683473923411051 4469 3125502 SGTC_3125 9127534 49.47 µM -1.48876472869942 0.0809481980906988 no 3138 0.0682746666477028 4394 1639235 SGTC_2155 5570423 76 µM -1.48898068449902 0.080916793356726 no 3139 0.0682462275676865 4463 797402 SGTC_281 1672-3440 14.9 µM -1.49542189918199 0.0799843216042483 no 3140 0.0674021843860684 4530 6833000 SGTC_941 3237-0776 460 µM -1.49565991949483 0.0799500205727382 no 3141 0.0673711499886941 4510 760008 SGTC_1774 st048371 48.465 µM -1.49617420685319 0.0798759447678872 no 3142 0.0673041320903828 4488 4242727 SGTC_955 1216-0110 33 µM -1.49640665832692 0.0798424804645222 no 3143 0.0672738577522202 4461 3619719 SGTC_2189 6047310 154.431 µM -1.49650255312105 0.0798286782967069 no 3144 0.0672613715405408 4482 711535 SGTC_3334 9142812 21.919 µM -1.49784686846502 0.0796353804867821 no 3145 0.0670865202879209 4497 45283678 SGTC_2238 6671620 73.2395 µM -1.49797512534003 0.0796169570743533 no 3146 0.0670698566682675 4406 729941 SGTC_1304 1165-0502 251 µM -1.49872227940034 0.0795096965048816 no 3147 0.0669728472100277 4489 767425 SGTC_3170 9103054 49.47 µM -1.50326528490309 0.0788598605314057 no 3148 0.0663853241747168 4466 16432970 SGTC_3147 9097027 49.47 µM -1.50343995381951 0.0788349562827369 no 3149 0.066362815085447 4507 25236841 SGTC_2690 usnic acid 100 µM -1.50432826226177 0.0787083936971726 no 3150 0.0662484327300923 4499 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_693 4161-2696 114 µM -1.50498229666099 0.0786153079874145 no 3151 0.0661643141322138 4535 805759 SGTC_3063 1327-0034 4 µM -1.50711019115346 0.0783130318559747 no 3152 0.0658912074953093 4382 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2795 7780010 54.55 µM -1.5076344740653 0.0782386908243722 no 3153 0.0658240522352064 4452 953673 SGTC_2364 9055074 200 µM -1.50940116518852 0.0779885757494929 no 3154 0.0655981477494069 4480 6470630 SGTC_2096 5468907 200 µM -1.51876320446856 0.076673282953841 no 3155 0.0644110554227593 4508 759785 SGTC_3025 9087895 49.47 µM -1.52141476259801 0.0763038427712236 no 3156 0.0640778932717623 4484 17173641 SGTC_674 0498-0004 451 µM -1.52516711404326 0.0757833465954793 no 3157 0.0636087104170498 4495 4231473 SGTC_1982 st072467 71.9 µM -1.52526053558392 0.0757704224950923 no 3158 0.0635970634616329 4495 3163533 SGTC_3197 9113331 49.47 µM -1.52891834710297 0.0752657130296851 no 3159 0.0631423436501317 4494 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_325 2810-4341 181 µM -1.52941560775974 0.0751972987306825 no 3160 0.0630807228173992 4504 774970 SGTC_2848 9016370 25.97 µM -1.53535821550862 0.0743833657618793 no 3161 0.0623479307720853 4480 7894410 SGTC_154 3389-1638 511.116 µM -1.536282721727 0.0742573471259726 no 3162 0.0622345276370997 4496 5238686 SGTC_524 r073-0010 27.8 µM -1.53922994517795 0.0738567019488407 no 3163 0.0618740847586652 4444 2772106 SGTC_96 0929-0093 37.281 µM -1.54303065820023 0.0733424749412585 no 3164 0.0614116687411981 4517 6991579 SGTC_3102 9121669 49.47 µM -1.54634999439939 0.072895621258838 no 3165 0.0610100319792348 4554 41905072 SGTC_1885 st057546 99.9 µM -1.54813111605949 0.0726567049313846 no 3166 0.0607953659272233 4551 702008 SGTC_843 0310-0051 143 µM -1.54836859308368 0.0726248955680239 no 3167 0.0607667891745837 4535 2065037 SGTC_2236 dapsone 200 µM -1.5501040493143 0.0723927598921098 no 3168 0.0605582721547128 4548 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1818 st052136 56.3 µM -1.5528342746071 0.0720287145719022 no 3169 0.0602313660352726 4166 674169 SGTC_293 4049-0273 38.5 µM -1.55343572105634 0.0719487073182191 no 3170 0.0601595372840977 4409 1380311 SGTC_2011 4012611 177 µM -1.55889941565096 0.0712250190208028 no 3171 0.0595100943374583 4493 2049887 SGTC_3237 9133362 49.47 µM -1.56184881466027 0.0708366888639991 no 3172 0.0591618044997428 4505 43845137 SGTC_1359 1582-0056 520 nM -1.56326098487363 0.0706513334672023 no 3173 0.0589956105235093 4563 3661189 SGTC_2948 9070189 9.45 µM -1.563737220769 0.0705889089068681 no 3174 0.0589396464428481 4471 6473636 YDL196W YDL196W SGTC_774 k060-0086 136 µM -1.56484688624629 0.0704436194604569 no 3175 0.0588094075236379 4520 5911235 SGTC_2804 7954240 19.48 µM -1.57114623502673 0.0696231936138103 no 3176 0.058074342612167 4546 828705 SGTC_3155 9099265 49.47 µM -1.57384270196272 0.0692742629684051 no 3177 0.0577619095831315 4500 25236499 SGTC_823 0417-1665 178 µM -1.57404684289392 0.0692479014947724 no 3178 0.0577383101901501 4568 3429856 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.57716162862512 0.0688466356222898 no 3179 0.0573791698057484 4546 2374 Ca(2+)-ATPase inhibitor. SGTC_1795 st049545 62.3 µM -1.58808730923976 0.0674532838916411 no 3180 0.0561332988056424 4505 5291882 SGTC_1087 pterostilbene 9.05 µM -1.58971056669032 0.0672481426725367 no 3181 0.0559500303776152 4539 5281727 Similar to reservatol, lowers cholesterol. SGTC_3061 glucosamine 200 µM -1.5916170254985 0.0670078278066471 no 3182 0.0557353911053757 4483 91431 and experimental redox chemotherapeutic SGTC_3142 9086498 49.47 µM -1.59801177869352 0.0662065985883162 no 3183 0.0550201778711863 4400 25236367 SGTC_92 0063-0024 660.874 µM -1.59882055805438 0.0661057935927347 no 3184 0.0549302398720294 4631 3594437 SGTC_531 3788-1495 174 µM -1.60304536189694 0.0655811522743081 no 3185 0.0544623197654323 4535 2896655 SGTC_1860 st056228 74.6 µM -1.60527924949085 0.0653050533052035 no 3186 0.0542161818268495 4538 688679 SGTC_3343 9148379 18.9835 µM -1.60881315431465 0.0648701204498399 no 3187 0.0538286018328111 4560 1955036 SGTC_2679 rapamycin 1 nM -1.61155205073704 0.0645345822515387 no 3188 0.0535297259706165 4419 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1209 2323-2347 50.3 µM -1.61511346791169 0.0641002964746567 no 3189 0.0531430624553906 4566 5412760 SGTC_2014 4013930 200 µM -1.61880030935737 0.0636531132266459 no 3190 0.0527451177815921 4530 64556 SGTC_2125 5246583 200 µM -1.61939222072636 0.063581545966747 no 3191 0.05268144978412 4559 835267 SGTC_2698 st077697 67.5 µM -1.62019847098855 0.0634841640079693 no 3192 0.0525948248910722 4532 3154499 SGTC_1211 1056-0033 32.3 µM -1.62420200502805 0.0630023203742765 no 3193 0.0521663515548618 4591 6741922 SGTC_393 acivicin 6.25 µM -1.62594502070544 0.0627934326407366 no 3194 0.0519806758270496 4409 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.63817748098167 0.0613426109834562 no 3195 0.0506923378827056 4561 688669 SGTC_3110 9122132 49.47 µM -1.64096829696202 0.0610153060422677 no 3196 0.0504019981632809 4574 918317 SGTC_2414 st077232 92.9 µM -1.64387410256953 0.0606759675215874 no 3197 0.0501011052854777 4512 729801 SGTC_2892 9047358 58.44 µM -1.64672866663552 0.0603440520502139 no 3198 0.0498069146014324 4568 6466771 SGTC_459 nigericin 15.3 µM -1.64812244955454 0.0601825065703762 no 3199 0.0496637731983023 4588 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3303 9125618 40.5795 µM -1.64850964726884 0.0601376888210935 no 3200 0.0496240663357894 4550 22695467 SGTC_1856 st057054 55.7 µM -1.65485757394404 0.0594066425746919 no 3201 0.0489766959972479 4539 1266018 SGTC_1632 st005650 90 µM -1.65502932239328 0.0593869607366932 no 3202 0.048959275047987 4592 2759605 SGTC_1376 2910-0861 41.3 µM -1.66827327494192 0.0578845822559972 no 3203 0.0476307453306997 4511 1112859 SGTC_815 1582-0027 36.9 µM -1.67068563360347 0.0576141718953493 no 3204 0.0473918939974843 4583 3128206 SGTC_2545 solidagenone 89.61 µM -1.67213137368609 0.0574525901786663 no 3205 0.0472492096161674 4533 6708572 An anti ulcer agent SGTC_2432 5630864 12.22 µM -1.67442435646638 0.0571970485576084 no 3206 0.0470236146452453 4570 5714970 SGTC_1755 st041960 45.185 µM -1.67824068866045 0.0567737215764589 no 3207 0.0466500607530372 4594 2257073 SGTC_1967 st070177 51.4 µM -1.67896956005451 0.0566931528310238 no 3208 0.0465789882001084 4587 5729214 SGTC_1299 1079-1439 3.74 µM -1.68750638964782 0.0557561911803411 no 3209 0.0457530111658908 4569 323161 SGTC_1658 st012944 20 µM -1.69445703822482 0.0550023818389009 no 3210 0.0450892344073312 4429 24207260 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.69459818870006 0.0549871576806651 no 3211 0.045075835460977 4585 641818 YHR062C RPP1 SGTC_1128 3448-9350 235 µM -1.69590623091301 0.0548462336817957 no 3212 0.0449518197353235 4554 619386 SGTC_2076 5212012 200 µM -1.69864037579954 0.0545525883070743 no 3213 0.0446934820131269 4584 604802 SGTC_2495 cafestol 54.53 µM -1.70075508150092 0.0543263241098379 no 3214 0.0444944936058985 4585 16667697 An anti-infammatory. SGTC_3266 9136860 49.47 µM -1.70693479112956 0.0536693755413846 no 3215 0.0439170866724727 4339 4871271 YPR165W RHO1 SGTC_1112 tnp00069 1.16933 µM -1.71143738852009 0.053194691123511 no 3216 0.0435002000684206 4571 145826 SGTC_1006 4099-6547 255 µM -1.71202310869937 0.0531331872271556 no 3217 0.0434462049610531 4602 3146833 SGTC_156 3474-0145 5.642 µM -1.71299283598111 0.05303148439514 no 3218 0.0433569287870344 4518 2265471 SGTC_373 0844-0104 25.9 µM -1.73109388347548 0.0511612761256415 no 3219 0.0417175105571749 4602 5375804 SGTC_1343 1487-0095 224 µM -1.73907346087237 0.0503536675432106 no 3220 0.0410109210695979 4592 4560101 YGL055W OLE1 SGTC_1827 berberine 7.24 µM -1.74061209996912 0.0501991173583302 no 3221 0.0408757976178785 4525 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3233 9132340 49.47 µM -1.7431198614131 0.0499480333058594 no 3222 0.0406563399774786 4620 17682950 SGTC_155 k072-0202 43.6 µM -1.74377031000743 0.0498830724285433 no 3223 0.0405995747816014 4600 5857737 SGTC_2671 danthron 100 µM -1.75731314229956 0.0485457829702871 no 3224 0.0394322244573213 4598 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2393 9031399 185.94 µM -1.78487231822513 0.0459130185194402 no 3225 0.0371410148330999 4599 1526623 YDL150W RPC53 SGTC_2460 5552655 174.22 µM -1.79773869417523 0.0447237918220426 no 3226 0.0361092132473748 4598 5401989 SGTC_2288 7946289 167.31 µM -1.79804533353295 0.0446957549906462 no 3227 0.0360849120419448 4620 1246052 SGTC_827 3253-0474 693 µM -1.8052864974243 0.0440377807172308 no 3228 0.0355149307328661 4638 5402065 SGTC_1084 voriconazole 435 nM -1.80606011416562 0.043967949600597 no 3229 0.0354544750813021 4648 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2244 6635614 200 µM -1.80693977555414 0.043888654812316 no 3230 0.0353858349366878 4580 836499 SGTC_875 0709-0210 25.7 µM -1.80860589663516 0.0437387828132896 no 3231 0.0352561258804436 4617 6251364 SGTC_1832 st054113 55 µM -1.81079700384086 0.0435423157948549 no 3232 0.0350861401456037 4648 1251267 SGTC_2776 terbinafine 19.92 µM -1.81645245019877 0.0430385071320271 no 3233 0.0346504978388268 4634 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_846 0335-0850 148 µM -1.82661506500967 0.0421450245345435 no 3234 0.0338788333327829 4633 6819598 SGTC_656 4090-1979 187 µM -1.82846304283901 0.0419841773597573 no 3235 0.0337400436716261 4659 22330961 SGTC_1235 benzylparaben 21.5 µM -1.83472791451168 0.0414425803489371 no 3236 0.0332730070363184 4675 7180 SGTC_35 0133-0054 64.071 µM -1.8362602768653 0.041310973327128 no 3237 0.0331595858438231 4591 99677 SGTC_2067 5224629 34.075 µM -1.83813063708307 0.0411507966526117 no 3238 0.0330215788228368 4614 2835000 SGTC_1718 roemerine 11.9335 µM -1.83878000259353 0.0410953032352427 no 3239 0.0329737753507102 4241 235224 An aporphine alkaloid with mutagenic activity. SGTC_2700 st077718 96.8 µM -1.8442135133241 0.040633341359848 no 3240 0.0325760148764049 4614 904970 SGTC_1281 0884-0031 11.8 µM -1.8488472289949 0.0402427167221004 no 3241 0.0322399377210294 4658 1548255 SGTC_1736 st036774 51 µM -1.85851385799784 0.0394376326242423 no 3242 0.0315480386477288 4663 1272247 SGTC_1043 0916-0009 19.3 µM -1.86031935349433 0.03928872417865 no 3243 0.0314201784975235 4649 3101130 SGTC_612 0302-0167 22.4 µM -1.86377137900026 0.0390052917382136 no 3244 0.0311769083218518 4636 235821 SGTC_2159 5658611 73.75 µM -1.86821671243355 0.038642757293726 no 3245 0.0308659351080315 4634 793844 SGTC_2136 5328288 199.296 µM -1.86843110362715 0.0386253424798483 no 3246 0.0308510025084755 4615 262395 SGTC_183 3914-0051 30.55 µM -1.89556209945715 0.036472590415848 no 3247 0.0290089864578851 4640 1596232 SGTC_1988 st071872 53.4 µM -1.89714614325194 0.0363499978770648 no 3248 0.028904326302914 4680 16414116 SGTC_49 0717-0965 32.132 µM -1.90225021999744 0.0359572748415145 no 3249 0.0285692251050853 4691 5889349 YGL099W LSG1 SGTC_3224 9130643 49.47 µM -1.91088309886975 0.0353009499658204 no 3250 0.0280098027441366 4642 17644395 SGTC_1039 k821-0043 94 µM -1.91128747822068 0.0352704490621262 no 3251 0.0279838236687894 4636 15992768 SGTC_97 0535-0701 19.132 µM -1.918319446981 0.034743500184219 no 3252 0.0275352590237011 4576 2832013 YGL099W LSG1 SGTC_659 k018-0002 107 µM -1.922767873644 0.0344135028640477 no 3253 0.0272546042188474 4638 6797879 YHR007C ERG11 SGTC_1842 st055362 61.2 µM -1.92461027244637 0.0342775846451867 no 3254 0.0271390666530194 4651 676032 SGTC_1707 st032323 6.317 µM -1.92906028935077 0.0339511153152358 no 3255 0.0268616890462791 4484 3132057 YMR211W DML1 SGTC_198 3454-2873 16.191 µM -1.94908528422187 0.0325135064237491 no 3256 0.0256426203774856 4678 710957 SGTC_172 1112-0046 2.638 µM -1.95330531981721 0.0322170440693238 no 3257 0.0253917137573981 4661 2802135 YIL048W NEO1 SGTC_1914 st062367 72.6 µM -1.96406895971501 0.0314709772836574 no 3258 0.0247610476586695 4643 978205 SGTC_866 0495-0101 262 µM -1.97193265387744 0.0309349929002485 no 3259 0.0243086475195443 4673 635694 SGTC_3344 9148862 3.898 µM -1.97289939570145 0.0308696249568086 no 3260 0.0242535127487968 4693 4905352 SGTC_1604 st002052 72.4 µM -1.97583469019326 0.0306718501169942 no 3261 0.0240867515299071 4713 6254834 YHR062C RPP1 SGTC_571 k831-0106 44.2 µM -1.99989532394568 0.029089921642322 no 3262 0.0227557841011368 4602 4783639 SGTC_2105 5350118 200 µM -2.00376871880874 0.0288417032379378 no 3263 0.0225474205798072 4665 2133313 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.00749037848784 0.02860486956306 no 3264 0.0223487370480851 4646 6857784 SGTC_938 3126-1755 342 µM -2.0193168347949 0.0278629874140578 no 3265 0.0217271496146875 4689 1777771 SGTC_1603 st002045 67.8 µM -2.02243610479045 0.0276700069063777 no 3266 0.0215656591430755 4691 5887985 SGTC_1330 1469-0054 61.8 µM -2.02974885012142 0.0272219515218519 no 3267 0.0211910373136488 4655 7102664 SGTC_1983 st071813 46.9 µM -2.02979908673776 0.0272188945587962 no 3268 0.0211884829210739 4725 11838595 SGTC_339 3091-4833 71.4 µM -2.03071823482376 0.0271630137453836 no 3269 0.0211417927482996 4518 3240077 SGTC_2778 tioconazole 65.09 nM -2.03355292729575 0.0269912773903523 no 3270 0.0209983460193427 4586 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.06066357104895 0.0253941365004554 no 3271 0.0196675736666278 4680 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1656 st012921 11 µM -2.06402994579097 0.0252014575026971 no 3272 0.0195074385997555 4621 6732821 SGTC_715 0868-0130 184 µM -2.06658342048848 0.0250561243327622 no 3273 0.0193867121979401 4733 2876258 SGTC_1476 4112-3294 3.34 µM -2.06705722096289 0.0250292350016509 no 3274 0.0193643812242086 4692 704369 SGTC_1878 temozolomide 1 mM -2.07109889582825 0.0248008419703413 no 3275 0.0191747775155987 4674 5394 DNA alkylating agent. SGTC_924 2046-0044 21.3 µM -2.07166452654541 0.0247690183325212 no 3276 0.0191483688595764 4680 3623589 SGTC_3136 9095672 49.47 µM -2.0789844500915 0.0243602639401347 no 3277 0.0188093898637583 4602 17217380 SGTC_2801 7907800 81.82 µM -2.11341861735894 0.0225126294793115 no 3278 0.017282476935502 4685 6620925 SGTC_1919 st067113 52.3 µM -2.11435949168543 0.0224638508900191 no 3279 0.0172422873576403 4664 1268243 SGTC_858 0438-0351 2.77 µM -2.12030362196225 0.0221577399470375 no 3280 0.0169902242111746 4723 2799119 SGTC_445 e6 berbamine 66 µM -2.12511006504913 0.0219127986527364 no 3281 0.0167887149631342 4704 6610268 A calcium/calmodulin antagonist. SGTC_2648 atorvastatin 78.68 µM -2.1426455510758 0.0210384716718304 no 3282 0.0160707852850948 4729 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2317 5986382 200 µM -2.14896514290502 0.0207306958950861 no 3283 0.0158185815906477 4711 877883 SGTC_1453 4237-0541 195 µM -2.15255650039073 0.02055749537504 no 3284 0.015676775169091 4713 739892 SGTC_1207 2099-0101 141 µM -2.1671780365282 0.0198649438936371 no 3285 0.0151106407135797 4723 5837381 SGTC_444 curcumin 90.4 µM -2.17417770439607 0.0195404746439953 no 3286 0.0148458960533443 4633 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1880 MG-132 525 µM -2.18961577217113 0.0188407261774778 no 3287 0.0142760570930783 4694 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_670 4204-0025 119 µM -2.19371251850285 0.0186586561129719 no 3288 0.0141280416485024 4710 719039 SGTC_409 arachidonic acid 100 µM -2.19944390271646 0.0184064532159242 no 3289 0.0139231869094627 4730 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2568 diosmetin 100 µM -2.21900046308346 0.0175676334896239 no 3290 0.0132433465145925 4724 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2275 7947463 200 µM -2.22541111119025 0.0172998666793695 no 3291 0.0130268261547939 4700 1225414 SGTC_396 dithiazanine 1.25 µM -2.23893686966748 0.0167463282838183 no 3292 0.0125800120457384 4717 10578 An antihelmenthic. SGTC_1875 nocodazole 6 µM -2.24919643983084 0.0163366275734417 no 3293 0.0122500004425952 4754 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_379 3970-0972 5.9 µM -2.26589193444518 0.0156882690353893 no 3294 0.0117290002856382 4738 2898042 YBL034C STU1 SGTC_562 3772-2733 112 µM -2.27272508290166 0.0154293452796592 no 3295 0.0115213760664418 4703 2876874 YIL048W NEO1 SGTC_2412 st077135 33.4 µM -2.27405286999453 0.0153794603600653 no 3296 0.0114814039529041 4714 13258915 SGTC_2319 6033012 152.6 µM -2.27592319427749 0.015309427294879 no 3297 0.0114253034986126 4704 847246 SGTC_2204 7233102 200 µM -2.28821926589864 0.0148557933937871 no 3298 0.0110623776516439 4763 2172480 SGTC_919 tnp00227 403.569 nM -2.29057121345788 0.0147703536105587 no 3299 0.0109941127209313 4704 1269246 A methoxyflavone. YNL221C POP1 SGTC_245 methotrexate 289.6 µM -2.29151452836342 0.0147362045146845 no 3300 0.0109668362878257 4705 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1859 st055998 20 µM -2.29371715708569 0.0146567311240042 no 3301 0.0109033752953249 4696 676301 SGTC_1243 0416-0003 5.65 µM -2.29406275003888 0.0146442952590595 no 3302 0.0108934473099469 4712 2141977 SGTC_1787 fluconazole 80 µM -2.30163160949893 0.0143742042320871 no 3303 0.0106779779923224 4418 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2779 methotrexate 400 µM -2.32602126954749 0.0135328533153968 no 3304 0.0100087080169841 4718 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_548 1436-0017 110 µM -2.33213380905926 0.013328779185787 no 3305 0.00984682647251442 4762 9677137 SGTC_971 1315-0384 26.7 µM -2.33551464682719 0.0132170517936167 no 3306 0.0097582758283141 4757 6769120 SGTC_514 4466-0038 2.65 nM -2.33644016896787 0.0131866072665847 no 3307 0.00973415623633486 4590 5722064 SGTC_934 2950-0684 338 µM -2.33920108832037 0.0130961481070997 no 3308 0.00966251439774321 4741 1121253 SGTC_702 1488-0190 94 µM -2.34987319819822 0.0127515107889465 no 3309 0.00938990372703473 4757 949357 SGTC_701 4424-0219 185 µM -2.36359009297149 0.0123200924972572 no 3310 0.00904941272747978 4752 2911779 SGTC_1531 st059297 52.4 µM -2.37624819410973 0.0119332515766377 no 3311 0.00874484709406998 4756 7566702 SGTC_2777 climbazole 1.536 µM -2.40192140443681 0.0111809020002325 no 3312 0.00815460606000562 4568 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2636 apigenin dimethyl ether 100 µM -2.40972482973645 0.0109605522582186 no 3313 0.00798227812906559 4704 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2146 5545642 200 µM -2.4248222161859 0.0105449459055681 no 3314 0.00765794254112945 4742 825326 SGTC_473 2-arachidonoylglycerol 10 µM -2.42983542388888 0.0104100106233316 no 3315 0.00755284012794312 4665 5282280 An endocannabinoid. SGTC_3034 9090421 49.47 µM -2.46233309584245 0.00957126091115998 no 3316 0.00690182012921839 4742 17173761 SGTC_1346 1488-2224 62.4 µM -2.47787957626709 0.00919133948991 no 3317 0.00660828722676581 4756 3722427 SGTC_1465 k213-0056 144 µM -2.49282090741575 0.00883871300062578 no 3318 0.0063366375554804 4710 24048857 YMR208W ERG12 SGTC_1244 0416-0015 52.5 µM -2.49793784048856 0.0087207051681678 no 3319 0.00624590478587608 4750 96201 SGTC_2191 5911152 200 µM -2.50177176644177 0.0086331938665398 no 3320 0.00617867796602942 4764 2875902 SGTC_1763 st044482 94.5 µM -2.57431824195198 0.00711646261774398 no 3321 0.00502189213110701 4762 88505 SGTC_451 chloral hydrate 100 µM -2.58223221810327 0.00696614994849539 no 3322 0.00490817543515282 4760 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2858 9025781 8.96 µM -2.60721549362541 0.00650986354947558 no 3323 0.00456409463958184 4639 4894980 YPL153C RAD53 SGTC_2186 6124449 200 µM -2.6094504036015 0.00647036377150723 no 3324 0.00453438954647298 4781 3834182 YLR033W RSC58 SGTC_953 1188-0045 9.7 µM -2.61627087456768 0.00635112659227024 no 3325 0.00444480021839252 4740 6144426 SGTC_959 1222-0044 107 µM -2.63874918112675 0.005971807000718 no 3326 0.0041606260694603 4773 6083612 SGTC_3210 9128157 49.47 µM -2.64203449136549 0.00591808374082052 no 3327 0.0041204831531024 4708 17590849 SGTC_151 3013-0144 2.285 µM -2.6516316840899 0.00576359170050695 no 3328 0.00400519349495581 4595 906558 YHR107C CDC12 SGTC_1612 st002233 45.4 µM -2.66199892533238 0.00560073481554362 no 3329 0.00388390632359559 4789 1035021 SGTC_3111 9122088 49.47 µM -2.6726665645044 0.00543743789700586 no 3330 0.00376255030413724 4771 16876704 SGTC_1050 3232-1156 69.3 µM -2.69708380560464 0.00507949483311019 no 3331 0.00349748318520333 4762 700529 SGTC_2651 TUB2.036 5 µM -2.70521955847811 0.00496497670383723 no 3332 0.0034129628474084 4679 15992207 YFL037W TUB2 SGTC_2350 9023895 38.85 µM -2.71507756771191 0.00482930199800238 no 3333 0.00331301244719024 4752 2997209 SGTC_1101 ebselen 5.29 µM -2.71731850422921 0.0047989251632335 no 3334 0.00329066200598637 4792 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2322 7413319 38.22 µM -2.72181537021255 0.00473848171747248 no 3335 0.00324622019665817 4735 1840400 SGTC_663 1486-0733 13.9 µM -2.74013513233547 0.00449919960839597 no 3336 0.00307069641938102 4782 722445 YPR165W RHO1 SGTC_1754 st042065 16.137 µM -2.74124255247046 0.00448508716936892 no 3337 0.00306036528056592 4650 1126236 YIL048W NEO1 SGTC_513 4245-1575 41.7 µM -2.74708483486418 0.00441128826793099 no 3338 0.00300637897651592 4668 719745 SGTC_2009 4012297 12.05 µM -2.78149580292753 0.00399821646514961 no 3339 0.00270545151569556 4750 45595307 SGTC_1902 st060212 70.5 µM -2.82692705989276 0.00350601001615826 no 3340 0.00234985156968345 4778 688944 SGTC_2409 alverine citrate 63.97 µM -2.84859935200772 0.00329097095565431 no 3341 0.00219560701762508 4750 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1061 3448-9325 110 µM -2.96275564539299 0.00234214217708688 no 3342 0.00152449252977587 4779 723482 SGTC_457 grayanotoxin iii 135 µM -2.97707587311387 0.00224252484720305 no 3343 0.00145505990733672 4678 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2273 7815444 169.05 µM -3.05211121522062 0.00178059224870132 no 3344 0.00113618944974826 4771 2824616 SGTC_2405 ticlatone 3.52 µM -3.05940945480762 0.00174063484241974 no 3345 0.00110886907357074 4708 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2188 6126565 140.678 µM -3.06744975058719 0.00169756075464683 no 3346 0.00107946877775596 4779 874518 SGTC_2905 7799065 20.05 µM -3.1404623630093 0.00134860090881862 no 3347 0.000843406901231368 4777 1296806 SGTC_2906 7926292 26.41 µM -3.16928139939975 0.00122992450417004 no 3348 0.000764081816429965 4782 2966319 SGTC_1900 st060200 72.8 µM -3.24835542288361 0.000951679932009455 yes 3349 0.000580370900520147 4795 688945 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -3.6002491121437 0.00028434291136766 yes 3350 0.000158956226288017 4783 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2328 6201408 200 µM -3.60155393450854 0.000283014485892183 yes 3351 0.000158160389682018 4788 2890418 SGTC_2752 diclazuril 33.15 µM -3.66214541053871 0.000227325010328774 yes 3352 0.00012505590786565 4788 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1731 st035964 63 µM -4.15341097036996 3.4097085100718e-05 yes 3353 1.63777844028831e-05 4797 6739575 SGTC_2896 9052656 71.43 µM -5.05477662998949 5.97362811775511e-07 yes 3354 2.15447390569071e-07 4688 6469436 SGTC_453 enantio-paf c16 10 µM -6.07006165179408 2.59468734911089e-09 yes 3355 6.39305775743724e-10 4716 13871343 A lipid and platelet activating factor