SGTCid condition conc unit RET1|YOR207C.score RET1|YOR207C.strain.pval RET1|YOR207C.strain.significant RET1|YOR207C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1915 st067105 30.6 µM 34.2044428066355 3.13863990779731e-253 yes 1 1.03840195719397e-256 1 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_210 3551-0445 56.827 µM 32.9545696787728 2.7007894981154e-235 yes 2 1.81926688444878e-238 1 2865180 YOR207C RET1 SGTC_1643 st009866 20.2 µM 28.0838373305211 9.7072381277039e-172 yes 3 7.7171868904526e-174 1 3156273 YOR207C RET1 SGTC_2233 sulbentine 40.3845 µM 26.7488860491543 4.42441265808912e-156 yes 4 6.36088886810012e-158 1 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_177 1327-0068 8.361 µM 24.3969295969766 2.46502421454791e-130 yes 5 9.21724783875466e-132 1 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2544 sphondin 68.51 µM 22.0370926201179 7.28762068155502e-107 yes 6 6.3518760015747e-108 2 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_829 1635-0120 117 µM 19.5615378716366 8.77004777506531e-85 yes 7 1.64501691003473e-85 2 285054 SGTC_2612 dictamnine 15.46 µM 18.4500341038392 1.02527998912064e-75 yes 8 2.60560965342874e-76 3 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2411 st077133 39.94 µM 16.5801811770379 1.21067098001257e-61 yes 9 4.84680668034649e-62 5 1403142 YNL221C POP1 SGTC_2510 benzyl isothiocyanate 8.31 µM 16.3404220778189 6.02796201577871e-60 yes 10 2.54496662027945e-60 1 2346 DNA damaging agent; causes G2/M arrest. SGTC_2323 6148992 148.28 µM 15.5547989353406 1.48083336495182e-54 yes 11 7.38090472172596e-55 2 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2921 7974240 10.71 µM 15.5315185135645 2.11957060702285e-54 yes 12 1.06146291168072e-54 2 2979074 YDR527W RBA50 SGTC_611 3453-1652 23.7 µM 15.0390761634004 3.68800793332091e-51 yes 13 2.03596488889074e-51 1 1560575 SGTC_503 tyrphostin 8 294 µM 14.9596764793885 1.20134487685501e-50 yes 14 6.73395806292696e-51 1 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2306 7482397 179.52 µM 13.7522338136351 3.54825619592395e-43 yes 15 2.46904728751506e-43 1 891448 SGTC_1930 st074634 34.3 µM 13.6050303418677 2.62142043133458e-42 yes 16 1.8690662747979e-42 2 684253 YOR116C RPO31 SGTC_2151 5563267 85.4165 µM 12.898867441269 2.86742103688043e-38 yes 17 2.28380357119117e-38 2 5310824 SGTC_1525 8-methoxypsoralen 92.5 µM 12.7945887314911 1.08653685610268e-37 yes 18 8.78902853100966e-38 2 4114 Related to psoralen; DNA damaging agent. SGTC_3317 9138495 8.753 µM 12.1349023546898 3.88609688069864e-34 yes 19 3.44961268935819e-34 1 17020139 SGTC_2522 biochanin a 4.94 µM 11.9891443272386 2.23788549779812e-33 yes 20 2.02533901431871e-33 2 5280373 A possible chelator. SGTC_897 1000-0139 31.4 µM 11.7411905219192 4.1939399576193e-32 yes 21 3.91876632844103e-32 1 6151020 SGTC_2738 aclarubicin 5.55 µM 10.8853082377939 6.5532539351639e-28 yes 22 6.77198245769139e-28 2 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1634 st006576 41 µM 10.6010979144654 1.38259521159561e-26 yes 23 1.47251151869975e-26 1 3915356 SGTC_2430 5571206 200 µM 10.6002493087186 1.39507633880196e-26 yes 24 1.48593460580409e-26 1 1731771 SGTC_87 0100-0052 35.5 µM 9.92502463659985 1.42509429554599e-23 yes 25 1.62011351774916e-23 4 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3282 9108498 15.4605 µM 9.82745532707693 3.7392449931514e-23 yes 26 4.28791457134521e-23 1 16459645 SGTC_820 1582-0060 59.9 µM 9.11385439335204 3.27285521519023e-20 yes 27 3.97529918416935e-20 2 3848840 SGTC_1661 st013063 9.66 µM 9.03022872228793 7.00940009141905e-20 yes 28 8.56566776661501e-20 4 721395 SGTC_2004 4023728 41.89 µM 8.78225026174426 6.44446083866281e-19 yes 29 8.01180333582592e-19 8 360084 YDR527W RBA50 SGTC_2246 7293507 91.5585 µM 8.68464235402058 1.51825747624567e-18 yes 30 1.89967937716332e-18 2 887656 SGTC_589 1227-0070 34.1 µM 8.40587751892071 1.66791752801256e-17 yes 31 2.12337083027219e-17 2 2841384 SGTC_1179 1021-1431 9.29 µM 8.07789477012222 2.54089159731943e-16 yes 32 3.29472145715732e-16 1 2840958 SGTC_2110 5483698 200 µM 7.81150780017267 2.15005023633099e-15 yes 33 2.82539260843165e-15 2 2848765 YHR062C RPP1 SGTC_2451 5856223 45.7 µM 7.71147811905125 4.71012489881909e-15 yes 34 6.21843919536165e-15 1 2179896 SGTC_2408 sulbentine 18.36 µM 7.66072882583402 6.98589078407647e-15 yes 35 9.24404307525784e-15 10 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2952 9073731 13.78 µM 7.65579500430631 7.25783662656308e-15 yes 36 9.60599898150904e-15 2 16457353 SGTC_1677 st019204 53.9 µM 6.91948358815144 1.66631622511899e-12 yes 37 2.26646497738085e-12 1 3945625 SGTC_2947 9072639 7.68 µM 6.85379241720883 2.63864414051282e-12 yes 38 3.59587100799176e-12 3 16488146 SGTC_3271 9137798 49.47 µM 6.78084993711048 4.37450282822738e-12 yes 39 5.97354610384674e-12 1 6498326 SGTC_1762 st045503 25.4615 µM 6.59772904969279 1.52165779343371e-11 yes 40 2.08751687554464e-11 2 4645554 SGTC_3264 9137442 49.47 µM 6.53461591503099 2.32095915238178e-11 yes 41 3.18864935266538e-11 1 17015726 SGTC_2019 4016004 108 µM 6.32501079743652 9.17663501926429e-11 yes 42 1.26607438107988e-10 2 45595336 SGTC_2113 5491891 107.031 µM 6.07689974943458 4.42322584361266e-10 yes 43 6.12641548006114e-10 3 789979 SGTC_2035 5154463 94.595 µM 5.97953748102326 8.06839555911345e-10 yes 44 1.11886035684545e-09 2 2769623 SGTC_2067 5224629 34.075 µM 5.90914204415732 1.2390217014475e-09 yes 45 1.71947039235799e-09 5 2835000 SGTC_1642 st009582 77.7 µM 5.52802047892835 1.1640473138813e-08 yes 46 1.61932126755477e-08 3 6739311 SGTC_839 0122-0028 230 µM 5.40848852501128 2.28405356804883e-08 yes 47 3.17794294119044e-08 16 759448 SGTC_1168 k815-0004 80.5 µM 5.32203388043356 3.68767632331713e-08 yes 48 5.13067272050009e-08 8 642433 SGTC_3247 9135149 49.47 µM 5.25694198341952 5.26445549932011e-08 yes 49 7.32352469937585e-08 15 8934436 YOR116C RPO31 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 5.11684959260864 1.11726332890474e-07 yes 50 1.55340585130268e-07 6 5355888 SGTC_136 0097-0015 404.482 µM 5.08030473328552 1.35542219622619e-07 yes 51 1.88414948154579e-07 5 4861337 SGTC_832 4083-0019 164 µM 5.07086236813786 1.42451778051683e-07 yes 52 1.98008549156832e-07 14 1990758 SGTC_2225 6654152 15.4 µM 5.05368659419694 1.55902145938214e-07 yes 53 2.16681260084195e-07 19 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1309 pyrazolanthrone 13.4 µM 5.02058502757629 1.85364248659677e-07 yes 54 2.57571707183957e-07 6 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_392 N-ethylmaleimide 8.33 µM 5.0193470387883 1.86564366962986e-07 yes 55 2.59237052003256e-07 6 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2018 5133068 143 µM 4.93785856729384 2.84397023354097e-07 yes 56 3.94925451659475e-07 5 785362 SGTC_184 1494-0393 24.714 µM 4.93424161841351 2.89726754008997e-07 yes 57 4.02313919027792e-07 18 3090647 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 4.92546428345516 3.03063916674013e-07 yes 58 4.20801414740607e-07 4 16725076 SGTC_1024 4507-0395 26 µM 4.9248059482288 3.04087770086747e-07 yes 59 4.2222055817623e-07 3 4201836 SGTC_2829 7992743 58.44 µM 4.9158432450134 3.18362733446502e-07 yes 60 4.42005566969981e-07 2 16462845 SGTC_831 k061-1017 217 µM 4.91399671879112 3.21382909088957e-07 yes 61 4.46191218008492e-07 2 1240153 SGTC_3223 9129970 49.47 µM 4.64247797640511 1.2437295393901e-06 yes 62 1.72127671633274e-06 2 17248386 SGTC_2601 securinine 100 µM 4.5901845213493 1.60117846618324e-06 yes 63 2.2142716860096e-06 10 442872 A GABA receptor antagonist. SGTC_2328 6201408 200 µM 4.53271401408741 2.1072813050508e-06 yes 64 2.91153147437809e-06 8 2890418 SGTC_860 0443-0016 25.1 µM 4.52303700994446 2.20635053285067e-06 yes 65 3.04792880208796e-06 5 5337942 SGTC_2949 9072542 2.23 µM 4.43529447841931 3.33297555778832e-06 yes 66 4.59732572689459e-06 9 16457352 SGTC_3236 9132701 49.47 µM 4.34679602394271 5.01584089384134e-06 yes 67 6.90702865681498e-06 2 24282524 SGTC_1834 st055981 52.8 µM 4.31608309850132 5.77032481652545e-06 yes 68 7.94111052813427e-06 7 471719 YDL150W RPC53 SGTC_2172 5754775 163.918 µM 4.29071695719157 6.47398846697858e-06 yes 69 8.9048596586591e-06 8 2263357 SGTC_138 0850-0259 40.9225 µM 4.26015438464867 7.43073598779309e-06 yes 70 1.02142873717086e-05 47 6813004 SGTC_3001 9076041 71.4286 µM 4.14581456989124 1.23481016424457e-05 yes 71 1.69303888525253e-05 1 16004211 SGTC_133 0724-0033 378.92 µM 4.1427709536266 1.25140744187523e-05 yes 72 1.71567300059931e-05 8 280309 SGTC_428 3448-4153 16.5 µM 4.08888843675594 1.58280931748122e-05 yes 73 2.16722621262074e-05 8 3834874 SGTC_1534 6-azauridine 81.6 µM 4.03427524787794 2.00279663881003e-05 yes 74 2.73855427964265e-05 7 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2299 7976368 114.88 µM 3.99456715798715 2.37240685641034e-05 yes 75 3.24062744153767e-05 6 2979718 SGTC_2495 cafestol 54.53 µM 3.9696369672782 2.63657876701495e-05 yes 76 3.59911098866506e-05 10 16667697 An anti-infammatory. SGTC_2311 7694451 200 µM 3.91354235089406 3.33647259850646e-05 yes 77 4.54759698983168e-05 10 2163142 SGTC_594 1487-1584 10.8 µM 3.90146037709323 3.50867378965456e-05 yes 78 4.78070568160938e-05 8 5013332 SGTC_2493 resveratrol 26.09 µM 3.89565385735109 3.59439263962967e-05 yes 79 4.89670849682528e-05 4 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2837 9008476 45.46 µM 3.89336943059172 3.62865643500646e-05 yes 80 4.94307116923287e-05 5 2992805 SGTC_2093 5331342 194.4 µM 3.88671010213712 3.73031029491622e-05 yes 81 5.08059909596534e-05 5 33839 SGTC_2016 5121758 140 µM 3.82252499468864 4.85820317776199e-05 yes 82 6.60460421803154e-05 17 2795203 SGTC_673 1082-0474 110 µM 3.79391892399846 5.45847784720115e-05 yes 83 7.41440556439121e-05 55 3098046 SGTC_1483 3453-0561 55.9 µM 3.76621777293453 6.10592339621844e-05 yes 84 8.28696203410242e-05 4 4546991 SGTC_1432 4049-0298 68.4 µM 3.76065955996747 6.24426795152757e-05 yes 85 8.47329686583239e-05 2 741646 SGTC_2989 9073649 71.4286 µM 3.74722399552574 6.59098275839999e-05 yes 86 8.94012035500452e-05 12 21367202 SGTC_548 1436-0017 110 µM 3.72903400503891 7.08936567937066e-05 yes 87 9.61076073099881e-05 8 9677137 SGTC_800 3448-7362 155 µM 3.69716366008229 8.04916965361686e-05 yes 88 0.000109010897232934 53 15991913 SGTC_159 3970-0959 50 µM 3.6526221515114 9.59692259568056e-05 yes 89 0.000129788024425591 21 6615653 SGTC_735 3076-0345 636 µM 3.64334490455675 9.95268174348825e-05 yes 90 0.000134558918911695 5 2888990 SGTC_2526 patulin 37.61 µM 3.63936676140107 0.00010108997939116 yes 91 0.000136654652901436 15 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3139 9095020 49.47 µM 3.63305704252242 0.000103616687820094 yes 92 0.000140041534603307 7 25236292 SGTC_1863 st057641 20.1 µM 3.55108965779765 0.000142315506801123 yes 93 0.000191819851941397 6 3921635 SGTC_1073 triclabendazole 3.09 µM 3.53962368938522 0.00014870163621595 yes 94 0.000200348974824718 2 50248 An antihelmetic and likely tubulin inhibitor. SGTC_540 1187-0821 17.3 µM 3.53560262967589 0.00015100408731717 yes 95 0.000203423088263845 10 847520 SGTC_3212 9128307 49.47 µM 3.52410617353216 0.000157772462585708 yes 96 0.000212456974393443 15 27243542 SGTC_168 3970-0862 530.542 µM 3.49709872379595 0.000174806140917558 yes 97 0.000235173867630143 59 3135186 SGTC_911 3456-4043 236 µM 3.48572123189011 0.000182484611999653 yes 98 0.000245406095066219 19 914281 SGTC_1256 0570-0116 285 µM 3.47265952416005 0.00019168817952872 yes 99 0.000257664327128398 8 410638 SGTC_3355 9151058 44.0485 µM 3.45365613967174 0.000205855587905262 yes 100 0.000276521024819821 7 17015728 SGTC_2496 diffractaic acid 79.83 µM 3.43859801889616 0.000217769934274074 yes 101 0.000292367403558352 11 94870 An apoptosis inducer which activates caspases. SGTC_2026 5148700 152 µM 3.4344693957169 0.000221147308687572 yes 102 0.000296857555060038 9 79838 SGTC_2073 5212005 126 µM 3.4120608077203 0.0002403472224293 yes 103 0.000322368645955052 11 691789 SGTC_2090 5301565 104.445 µM 3.41175608698881 0.000240618714441779 yes 104 0.000322729203973675 12 2056344 SGTC_2226 7298446 200 µM 3.39583441273782 0.000255208717813598 yes 105 0.000342098688097445 7 3283010 SGTC_1050 3232-1156 69.3 µM 3.3714250094468 0.000279185810028335 yes 106 0.000373901972120284 28 700529 SGTC_2470 5664817 21.68 µM 3.37068835183278 0.000279941028587724 yes 107 0.000374903146155129 9 2859561 SGTC_2378 9074213 121.43 µM 3.33142619466156 0.000323058771773026 yes 108 0.000432011040403249 28 657714 SGTC_682 0kpi-0099 17 µM 3.32084603849673 0.000335692248619126 yes 109 0.000448725148098738 50 1714895 YML126C ERG13 SGTC_3215 9129942 49.47 µM 3.31644573974027 0.000341080538698217 yes 110 0.000455851446871721 10 17682944 SGTC_2533 agelasine 13.65 µM 3.30502142363721 0.000355447552735746 yes 111 0.000474845701863431 23 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3144 9087057 49.47 µM 3.30244356241902 0.000358766249778618 yes 112 0.00047923186729876 9 17249618 SGTC_625 k213-0058 121 µM 3.28631703912382 0.000380189305178384 yes 113 0.000507533459140944 34 3655420 SGTC_2634 4'-methoxyflavone 100 µM 3.22346710080175 0.000475526122342805 yes 114 0.000633244229016485 16 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2565 isoliquiritigenin 100 µM 3.21010357581279 0.000498462873660267 yes 115 0.000663435756067283 18 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1200 1643-0193 18.4 µM 3.17868699497976 0.000556478419100664 yes 116 0.000739718778668744 12 5403974 SGTC_2112 5488546 200 µM 3.15124395224376 0.000612201190495617 yes 117 0.00081288319092773 17 600757 SGTC_179 1273-0063 6.77 µM 3.14889007398377 0.000617213106148284 yes 118 0.000819459160321246 10 3108139 SGTC_961 1252-1571 372 µM 3.10748399477374 0.000711806736752629 yes 119 0.00094343601156373 14 6813498 SGTC_828 2074-0507 139 µM 3.09438712366368 0.000744402361114965 yes 120 0.00098609982095041 13 X828 SGTC_2396 5342950 42.78 µM 3.08367630569886 0.000772075864761906 yes 121 0.00102229961267731 54 1886677 SGTC_1042 0350-0096 82 µM 3.08315371240672 0.000773450026070786 yes 122 0.00102409665295615 15 3122515 SGTC_2466 5983409 37.09 µM 3.04621279647608 0.000876492253007115 yes 123 0.00115871879314665 19 2879657 SGTC_785 1270-0111 65.3 µM 3.04464713412415 0.000881126306610024 yes 124 0.00116476725933115 20 6741994 SGTC_2339 9000433 200 µM 3.03526872019096 0.000909359367188676 yes 125 0.00120160730706679 14 2988954 SGTC_2135 5326629 150.42 µM 3.00479518292623 0.00100693585171201 no 126 0.00132879871542736 13 5020077 SGTC_659 k018-0002 107 µM 3.00225586531934 0.0010154857217625 no 127 0.00133993414078507 19 6797879 YHR007C ERG11 SGTC_1000 4048-0884 8.67 µM 2.96322333115678 0.00115556867299679 no 128 0.0015221780040202 18 13040088 SGTC_1872 amphotericin b 148 nM 2.95083457948437 0.00120360065584565 no 129 0.00158458298432075 30 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 2.94660136665593 0.00122042749090604 no 130 0.00160643547462243 12 2374 Ca(2+)-ATPase inhibitor. SGTC_997 3996-0078 137 µM 2.93776746302865 0.00125623729811747 no 131 0.00165292439809998 21 735687 SGTC_499 genistein 192 µM 2.90611628190109 0.0013925750645319 no 132 0.0018297271401823 5 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3103 9120822 49.47 µM 2.90548373080287 0.00139543254329751 no 133 0.00183342955684114 24 17141819 SGTC_3218 9131285 49.47 µM 2.90518068594069 0.00139680341095304 no 134 0.0018352057363767 15 17156417 SGTC_274 sirtinol 40.1 µM 2.88095735744227 0.00151044377376789 no 135 0.00198234638038559 23 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1242 0402-0103 60.1 µM 2.86534155219922 0.00158810901412279 no 136 0.00208279839244776 22 432868 SGTC_2915 7971052 15.16 µM 2.86089342389566 0.00161088844619571 no 137 0.00211224519128558 11 5741558 SGTC_2446 5162541 200 µM 2.85925734715697 0.00161934162306439 no 138 0.00212317073037681 14 1549321 SGTC_1969 st069479 40.1 µM 2.85855398324281 0.00162298812590141 no 139 0.00212788345034889 13 3895485 SGTC_1711 st032263 62.8 µM 2.8514585701129 0.00166019404694127 no 140 0.00217595785289205 11 3958979 SGTC_671 0560-0003 407 µM 2.82994922493645 0.00177777800484034 no 141 0.00232776959339065 9 3238678 SGTC_2681 menadione 3.18 µM 2.77567650048875 0.00210888863317481 no 142 0.00275434949760833 16 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2184 6075246 200 µM 2.77445789871605 0.00211692674974466 no 143 0.00276468952266937 12 2267320 SGTC_704 1310-0270 142 µM 2.77127588067991 0.00213804709613957 no 144 0.0027918548049629 20 5718033 SGTC_799 1310-0557 151 µM 2.75985002672036 0.00221546940737347 no 145 0.00289139508262286 20 5354492 SGTC_3346 9158254 43.5805 µM 2.74801458752893 0.00229833798636443 no 146 0.00299786707303101 39 17639500 SGTC_2848 9016370 25.97 µM 2.73092482260991 0.0024229532063128 no 147 0.00315784382573419 13 7894410 SGTC_1246 0422-0085 105 µM 2.73076514659611 0.00242414581603263 no 148 0.00315937410639537 27 264295 SGTC_1973 st070275 50.2 µM 2.70202216741604 0.00264768108477131 no 149 0.00344595836535213 13 17118334 SGTC_195 4234-0266 16.654 µM 2.68858779906054 0.00275841112763565 no 150 0.00358774815490786 39 2303354 SGTC_2313 7726885 200 µM 2.67937614397505 0.00283673376893967 no 151 0.00368797425225564 31 726423 SGTC_3270 9137563 49.47 µM 2.67113851099582 0.00290846773860318 no 152 0.00377972230956189 16 17015724 SGTC_385 1494-0393 12.4 µM 2.66833099958505 0.00293328691049496 no 153 0.00381145588867883 22 3090647 SGTC_967 1306-0166 352 µM 2.6553490284639 0.00305055141231915 no 154 0.00396131939253123 14 4437607 SGTC_1133 3473-0247 50 µM 2.64633899559928 0.00313440255037609 no 155 0.00406841145518255 78 711311 SGTC_446 go6976 132 µM 2.59550033019142 0.00364760055758355 no 156 0.00472266560972958 13 3501 A protein kinase C inhibitor. SGTC_394 menadione 8.33 µM 2.59138657184996 0.00369225529676848 no 157 0.00477950237347763 27 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1301 naphtanilide LB 4.81 µM 2.57188712341236 0.00391066287725332 no 158 0.00505729315977001 38 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_885 0865-0106 16.8 µM 2.56823455503887 0.00395283818782151 no 159 0.00511089825303047 48 2793380 SGTC_1662 st014054 52 µM 2.56681334260877 0.00396935836918118 no 160 0.00513189227929894 9 2838777 SGTC_324 1315-0088 19.6 µM 2.55061145651901 0.00416210665183644 no 161 0.00537670671144786 40 6787421 SGTC_2905 7799065 20.05 µM 2.54816233148767 0.00419196045745533 no 162 0.00541460334119507 29 1296806 SGTC_539 4859-0462 2.54 µM 2.54427995823465 0.00423967754827915 no 163 0.00547516401649334 45 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3048 9093155 49.47 µM 2.53528290319444 0.00435212958901691 no 164 0.00561782735481595 15 25236002 SGTC_1685 st024049 53.0905 µM 2.49250820986431 0.00492404505562147 no 165 0.0063422199042883 23 1941139 SGTC_2351 9026858 72.31 µM 2.49006426377232 0.0049586575323954 no 166 0.00638599996454367 33 1409300 SGTC_882 0843-0131 351 µM 2.46663912940236 0.00530157204571677 no 167 0.00681938662502071 44 5425421 SGTC_995 3931-2021 34.6 µM 2.45824183015196 0.00542953969390245 no 168 0.00698095609441878 35 730143 SGTC_3201 9113999 49.47 µM 2.45301891874666 0.00551051041437351 no 169 0.00708314439362267 38 16649224 SGTC_975 1335-0046 28.5 µM 2.45010113299228 0.00555621036189753 no 170 0.00714080477279102 30 16486740 SGTC_2909 7941780 10.49 µM 2.4480292110022 0.00558886603322523 no 171 0.00718200048611955 25 1243215 SGTC_330 1488-0319 80.1 µM 2.44652991974211 0.00561260263416277 no 172 0.00721194125563869 34 6846614 SGTC_2442 5158906 48.48 µM 2.44128515563893 0.00569634302025245 no 173 0.00731754678001554 19 1893835 SGTC_2200 6600604 21.907 µM 2.43006337385604 0.00587925012092092 no 174 0.00754809147683992 31 2904777 SGTC_81 0411-0046 9.971 µM 2.41473851164715 0.00613744291857091 no 175 0.00787325483854844 77 12925265 SGTC_445 e6 berbamine 66 µM 2.39899576347396 0.00641308752756829 no 176 0.0082200524495198 69 6610268 A calcium/calmodulin antagonist. SGTC_45 0kpi-0036 14.9 µM 2.39073721797099 0.0065620246441564 no 177 0.00840729145995087 27 2795021 SGTC_2025 5147754 141 µM 2.38082437243743 0.00674482886600788 no 178 0.00863697269187283 24 315777 YLR208W SEC13 SGTC_782 0083-0095 30.5 µM 2.37904150331826 0.00677818027942524 no 179 0.00867886075515404 34 3591729 An indicator and reagent. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.37020747744272 0.00694559351876059 no 180 0.00888905286823874 32 5357218 A potent inhibitor of glutathione S-transferases. SGTC_770 0389-1121 67.2 µM 2.35631997661964 0.00721615950237016 no 181 0.00922850572702355 33 6753108 SGTC_2260 7964312 200 µM 2.35571478784241 0.00722815872802314 no 182 0.00924355294348548 36 231951 SGTC_3228 9131799 49.47 µM 2.34828661695123 0.00737687859684092 no 183 0.00943000108940203 25 17015818 SGTC_1773 st048542 73.5835 µM 2.34137156287635 0.00751774241208916 no 184 0.00960651766110607 88 3237138 SGTC_931 2812-0076 566 µM 2.34064629277959 0.00753265300616523 no 185 0.00962519749046202 30 3450959 SGTC_331 k048-0133 24.5 µM 2.31879926370045 0.00799417917040753 no 186 0.0102029615745009 42 6813582 SGTC_1386 3228-0095 33.8 µM 2.3130672525616 0.00811931365528691 no 187 0.0103594709232521 34 870181 SGTC_3123 9126162 49.47 µM 2.30119322773914 0.00838402123677309 no 188 0.0106903557616735 28 25239884 SGTC_282 k297-0036 65.7 µM 2.29603130778569 0.00850143897407326 no 189 0.0108370456737454 36 5061378 SGTC_3009 9080819 71.4286 µM 2.29075447449817 0.00862295976019149 no 190 0.0109888090196783 42 17027216 SGTC_1524 corynanthine 62.1 µM 2.28133257542011 0.008843730171062 no 191 0.0112643872502615 41 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_877 0771-0151 33.1 µM 2.27421046091914 0.00901388528824005 no 192 0.0114766677930691 27 6166523 SGTC_1322 1348-1070 12 µM 2.26287730057485 0.00929056064744295 no 193 0.0118216270236552 29 6758089 SGTC_586 0957-0265 8.15 µM 2.25433131964825 0.00950407982734515 no 194 0.0120876662104682 80 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1229 0139-0193 12.2 µM 2.2503851517836 0.00960411349811735 no 195 0.0122122533671617 53 3090752 SGTC_1961 st076550 68.7 µM 2.22585078757803 0.0102469392274264 no 196 0.0130120888221324 38 1579337 SGTC_1368 1852-0141 284 µM 2.22547999434638 0.0102569355142089 no 197 0.0130245163357324 37 2838987 SGTC_2429 5902844 64.44 µM 2.20936898715766 0.010699567665361 no 198 0.0135744931581071 47 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_164 4100-3994 89.624 µM 2.19453966729459 0.0111215956101675 no 199 0.0140983177461231 46 4615967 SGTC_1954 st077032 68.9 µM 2.19398396561476 0.0111376878537803 no 200 0.0141182811473696 33 698907 SGTC_1964 st076914 61 µM 2.19298771690485 0.0111665883355363 no 201 0.0141541320409283 50 24208661 SGTC_791 1348-1292 225 µM 2.19045563155399 0.0112403360114665 no 202 0.0142456045999445 30 5437054 SGTC_1317 1273-0028 910 nM 2.18273730001356 0.0114677527582718 no 203 0.0145275806950713 57 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2259 7964009 200 µM 2.16741477034472 0.0119310895895077 no 204 0.0151016210142648 25 313134 SGTC_128 0906-2981 13.371 µM 2.16699409066759 0.0119440362609109 no 205 0.0151176523558359 59 6740226 SGTC_1891 st059073 26.2 µM 2.16418357424661 0.0120308446437102 no 206 0.0152251317031081 36 688754 SGTC_1030 k029-0042 36.7 µM 2.14339069498855 0.0126902367015599 no 207 0.0160408698197201 42 6080581 SGTC_34 0469-0683 81.75 µM 2.13994053408346 0.0128026219400022 no 208 0.0161797863972915 38 3690923 SGTC_619 1652-1634 108 µM 2.13642777930708 0.0129179296338827 no 209 0.0163222808975759 30 5400454 SGTC_2606 farnesol 9.78 µM 2.12839997560366 0.013184821993926 no 210 0.0166519675870122 63 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1207 2099-0101 141 µM 2.1279778637948 0.0131989864206716 no 211 0.0166694594829235 40 5837381 SGTC_2346 9031566 143.75 µM 2.12183077600432 0.0134067533625263 no 212 0.0169259756098337 46 4771086 SGTC_2476 5806916 10.51 µM 2.1209533797246 0.0134366378093758 no 213 0.0169628629406459 32 2870194 SGTC_115 0527-0192 112.043 µM 2.11928751913896 0.0134935359399013 no 214 0.0170330878897331 74 4233931 SGTC_2074 5212007 75.395 µM 2.11695564816973 0.0135735312060719 no 215 0.0171318060526104 37 758611 SGTC_3168 9103419 49.47 µM 2.100370291754 0.0141543917034129 no 216 0.0178481401310413 25 16649256 SGTC_366 0181-0206 4.31 µM 2.08266441056571 0.0147980088898043 no 217 0.0186409118125962 48 274874 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.07226950861413 0.0151874724097283 no 218 0.0191201571626901 60 23847180 SGTC_1170 0310-0127 64.8 µM 2.06882602904 0.0153184154921312 no 219 0.019281207473008 56 774975 SGTC_1895 st058434 18.3 µM 2.06272589531913 0.0155527622531229 no 220 0.0195693390790826 50 5393175 SGTC_1310 1188-0297 994 nM 2.05465760576901 0.015867440026969 no 221 0.0199560437104925 59 1588352 SGTC_2071 5230951 39.92 µM 2.04639847061449 0.0161952001951053 no 222 0.0203585912158377 50 1799272 SGTC_835 0312-0010 67.2 µM 2.04310699696079 0.016327428074901 no 223 0.0205209237147279 51 1626196 SGTC_118 0083-0097 135.343 µM 2.03401647039135 0.016697433160825 no 224 0.0209749674268341 85 5207356 SGTC_1176 0848-0131 83.3 µM 2.03167292609006 0.0167939757683111 no 225 0.0210933892616515 46 6769040 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.03149011495521 0.0168015267306812 no 226 0.0211026506438573 63 5393153 SGTC_3058 9093861 49.47 µM 2.0216166610902 0.0172136832688739 no 227 0.0216079847345394 56 17217477 SGTC_3003 9075612 71.4286 µM 2.02095005419039 0.0172418186905979 no 228 0.0216424678168015 46 6501993 SGTC_1682 st012968 530 nM 2.01945378016747 0.0173051148979109 no 229 0.0217200383147095 41 24207270 SGTC_1448 4255-0083 152 µM 2.01620614082637 0.0174431815374709 no 230 0.02188921228522 55 5399660 SGTC_1769 st044406 64.4 µM 2.01091649969703 0.0176700731378657 no 231 0.0221671386255281 77 670903 SGTC_1739 st037196 92.5 µM 2.00102317070096 0.0181011975164679 no 232 0.0226949464661857 39 612214 SGTC_639 0833-0042 114 µM 1.99519730924789 0.0183592432510419 no 233 0.0230106822035575 54 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2480 5767542 37.17 µM 1.98329874312783 0.0188960147815118 no 234 0.0236670348619014 44 2867358 SGTC_319 1348-1596 45.5 µM 1.98102671964869 0.0190000147240916 no 235 0.0237941386095824 53 5380505 SGTC_1814 st052110 31.539 µM 1.96764533562583 0.0196224624005474 no 236 0.0245544297817333 53 674163 SGTC_2763 lisinopril 49.32 µM 1.96553665809836 0.019722111840334 no 237 0.0246760785798493 40 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2474 5321570 43.32 µM 1.96136630412871 0.0199204549518044 no 238 0.0249181538889693 44 2841384 SGTC_1908 st060353 56.5 µM 1.95937205592506 0.0200158985257954 no 239 0.0250346153829897 68 4227716 SGTC_329 k048-0121 21.3 µM 1.95657376232899 0.0201504771068093 no 240 0.0251988011504683 46 6832902 SGTC_3225 9130819 49.47 µM 1.94175769570653 0.0208758808285343 no 241 0.0260832202135501 66 4547121 SGTC_1084 voriconazole 435 nM 1.94052478130437 0.0209372290697898 no 242 0.0261579727441991 63 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_667 1498-1044 59 µM 1.94045993341135 0.0209404600374846 no 243 0.026161909474843 54 6739982 SGTC_1370 2001-0092 44.6 µM 1.94020542481407 0.0209531446984818 no 244 0.0261773647539989 56 790957 SGTC_513 4245-1575 41.7 µM 1.937851275381 0.0210707836462192 no 245 0.0263206849699403 101 719745 SGTC_2456 5770359 74.46 µM 1.92943274899821 0.0214960474944917 no 246 0.0268385806940721 57 3118787 SGTC_3064 1327-0027 10 µM 1.92901441461462 0.021517367614029 no 247 0.0268645363812799 34 16000455 YPR107C YTH1 SGTC_1807 st050092 58.9 µM 1.91251764617103 0.0223724764904295 no 248 0.0279049157242045 51 5008496 SGTC_783 0848-0141 92.7 µM 1.90312528011252 0.0228720107423941 no 249 0.0285120999936333 69 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1828 st055811 49 µM 1.90025001901938 0.0230267979285674 no 250 0.0287001585104221 25 5877589 SGTC_2086 5274770 176.623 µM 1.88737471080558 0.0237307912898275 no 251 0.0295549720473751 71 689278 SGTC_2671 danthron 100 µM 1.87151377602304 0.0246228262305906 no 252 0.0306369511127081 80 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_840 0245-0196 390 µM 1.86944308144997 0.0247413344488479 no 253 0.0307805977691666 48 3827528 SGTC_360 0957-0399 1.01 µM 1.86411121336169 0.0250486872831862 no 254 0.0311530440789075 72 6752301 YPR165W RHO1 SGTC_1731 st035964 63 µM 1.86353699298387 0.0250819780223875 no 255 0.0311933764586186 82 6739575 SGTC_1434 4073-0095 163 µM 1.86003574461213 0.0252857682350995 no 256 0.0314402344768821 54 24133745 SGTC_627 1391-0720 175 µM 1.85992310811746 0.0252923472090688 no 257 0.0314482027317561 69 997839 SGTC_1505 k297-0037 20.6 µM 1.85495772814068 0.0255837979579736 no 258 0.0318011316369443 55 4089396 SGTC_2685 mycophenolic acid 18.85 µM 1.84281502335886 0.0263083977220685 no 259 0.0326780112817256 40 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_309 k408-0051 1.48 µM 1.83716830050382 0.0266511574867788 no 260 0.0330925268812299 118 3640463 SGTC_1466 k213-0079 57.5 µM 1.83672921744008 0.0266779657032298 no 261 0.0331249398858932 93 3657981 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.83614163209128 0.0267138759609621 no 262 0.0331683562088882 78 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1377 2944-0135 198 µM 1.82515178518095 0.0273929931519966 no 263 0.0339890636739704 60 1894137 SGTC_2963 9082507 9 µM 1.82038682142315 0.0276918867649857 no 264 0.0343500589626732 76 16459611 SGTC_1151 3909-8316 15.3 µM 1.81673701425361 0.0279226634984778 no 265 0.0346286956222817 61 800431 SGTC_2075 5212009 200 µM 1.81467718780611 0.028053611674874 no 266 0.0347867663764406 51 780898 SGTC_25 0118-0223 35.662 µM 1.8100195765964 0.028351593572003 no 267 0.0351463756829141 47 5333628 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.80768530622488 0.02850192216451 no 268 0.0353277463917325 74 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2701 st077767 14.721 µM 1.80088332113725 0.0289437603521106 no 269 0.0358606361902137 72 5721188 SGTC_302 1094-0063 18.9 µM 1.80006074181783 0.0289975766314864 no 270 0.0359255237989492 91 5440289 SGTC_1346 1488-2224 62.4 µM 1.78867997225018 0.0297507220521143 no 271 0.0368331850950052 81 3722427 SGTC_149 3970-0822 46.1 µM 1.77713311537605 0.0305313737452085 no 272 0.0377731704030227 78 3114250 YBL034C STU1 SGTC_2724 maprotiline 69.64 µM 1.77691985363306 0.0305459498652314 no 273 0.037790713668788 64 4011 A tricyclic antidepressant. SGTC_1506 4226-2149 212 µM 1.77377088137098 0.0307618491148811 no 274 0.0380505282380682 83 991114 SGTC_2057 5236571 38.335 µM 1.77359356123365 0.0307740439842316 no 275 0.0380652017497634 71 54684039 YBR257W POP4 SGTC_2347 9049783 174.81 µM 1.77338634567785 0.0307882999276599 no 276 0.0380823550012539 64 6467988 YPL169C MEX67 SGTC_132 0417-1715 25.805 µM 1.77233986846293 0.0308603786506159 no 277 0.0381690784699222 64 6769098 SGTC_854 0422-0053 192 µM 1.75167790583051 0.0323123629277755 no 278 0.0399146040470193 75 3596728 SGTC_588 3970-1144 52.9 µM 1.7429280627533 0.0329440109788809 no 279 0.0406730906997611 36 1888707 SGTC_1199 1638-0010 4.46 µM 1.74286910213287 0.0329483015971211 no 280 0.0406782411467425 69 3111136 SGTC_3183 9108214 49.47 µM 1.73046673073081 0.0338611246955436 no 281 0.0417734601628342 25 4974831 SGTC_1700 st030840 7.9285 µM 1.72928905704957 0.0339488734123023 no 282 0.0418786870798834 94 5499307 SGTC_153 4077-0274 519.67 µM 1.72604131541185 0.0341918328048092 no 283 0.0421699900891351 73 3121976 SGTC_1900 st060200 72.8 µM 1.72471190064132 0.0342916960624618 no 284 0.0422897026442012 75 688945 SGTC_945 3381-0768 11.3 µM 1.72306960955265 0.0344153928874477 no 285 0.0424379688834998 76 1126236 YIL048W NEO1 SGTC_2479 5617353 43.85 µM 1.71866591294823 0.0347488884304943 no 286 0.042837611116883 83 2731746 SGTC_1479 0549-0158 134 µM 1.71657758734259 0.0349079641250085 no 287 0.043028190241592 72 5440202 SGTC_2976 9009005 19.48 µM 1.71203805087725 0.0352558203282567 no 288 0.0434448282118669 43 2993148 SGTC_3224 9130643 49.47 µM 1.7055418668067 0.0357585519119556 no 289 0.044046705448381 75 17644395 SGTC_1311 1190-0148 100 µM 1.70508406364794 0.0357942011937276 no 290 0.044089373679274 87 1961333 SGTC_1155 4088-0394 48.2 µM 1.70471590860288 0.0358228906692015 no 291 0.0441237106852406 79 2326248 SGTC_2809 7964133 12.99 µM 1.70333737327872 0.0359304841590331 no 292 0.0442524751751535 84 1253665 SGTC_1106 tegaserod maleate 11.7 µM 1.7024424747953 0.0360004718106897 no 293 0.0443362267327748 83 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3065 9113888 49.47 µM 1.69876574502128 0.0362891918819047 no 294 0.0446816651382797 77 16648368 SGTC_1809 st050081 57.6 µM 1.69625780624658 0.0364872164085298 no 295 0.0449185336857283 73 5036894 SGTC_1135 dihydrocapsaicin 536.708 nM 1.69365971218803 0.0366932910882098 no 296 0.045164982124095 69 107982 A Capsaicinoid. SGTC_2798 7813637 45.45 µM 1.68143569003345 0.0376756849660549 no 297 0.0463391590275435 106 956368 SGTC_1330 1469-0054 61.8 µM 1.67772313240203 0.0379782633671767 no 298 0.0467005806911351 78 7102664 SGTC_771 0250-0039 27.3 µM 1.67604225833806 0.0381159073608993 no 299 0.0468649577792742 82 3005115 SGTC_1119 parthenolide 318.541 nM 1.67420910767519 0.0382664846006499 no 300 0.0470447550840667 86 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_563 tetrahydrosecaminediol 614 µM 1.67263733308517 0.0383959780015332 no 301 0.0471993563905731 52 334274 A psychoactive constituent of the cannabis plant. SGTC_2330 7979373 200 µM 1.66759624760191 0.0388137085665592 no 302 0.0476979518309697 85 1863007 SGTC_2709 st078560 56 µM 1.66474957783779 0.0390512291026834 no 303 0.0479813636597419 92 17250903 SGTC_3227 9130768 49.47 µM 1.66461649742582 0.0390623619608687 no 304 0.0479946459316532 54 17720899 SGTC_2208 7283366 200 µM 1.66130509175467 0.0393402110469604 no 305 0.0483260939611336 67 898663 SGTC_1811 st050069 61.5 µM 1.65707790450388 0.0396972347548221 no 306 0.0487518628380195 61 3877702 SGTC_2780 5215298 71.43 µM 1.65644282254619 0.0397511000294731 no 307 0.0488160875528512 104 2834131 SGTC_3294 9122953 26.2835 µM 1.65386808472393 0.0399700887759871 no 308 0.0490771592707392 80 16459826 SGTC_896 0964-0007 44.5 µM 1.64632936894617 0.0406169208397214 no 309 0.0498479830356387 87 6756758 SGTC_372 0155-0182 15.9 µM 1.64025661268386 0.041144127915279 no 310 0.0504759113515127 71 771486 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.6377482546698 0.0413635044175667 no 311 0.0507371099575116 83 688761 SGTC_1751 st044839 27.194 µM 1.63673886999506 0.041452050476014 no 312 0.0508425217473804 64 5291326 SGTC_2635 hydroquinidine 100 µM 1.63314197991735 0.0417688294019422 no 313 0.0512195696175205 52 442912 An experimental heart treatment. SGTC_2185 6113692 200 µM 1.63219316575206 0.0418527176714962 no 314 0.0513194000214389 87 874150 SGTC_3352 9151559 45.5865 µM 1.62933418031608 0.0421063165959564 no 315 0.051621147061748 68 17159339 SGTC_1978 st071761 42 µM 1.62839426336509 0.0421899606315633 no 316 0.0517206566219929 95 5147680 SGTC_2170 morpholine 200 µM 1.62792382860951 0.0422318754949664 no 317 0.0517705190523988 66 121171 Reacts with secondary amines. SGTC_1069 diphenylcyclopropenone 8.49 µM 1.61835469183066 0.0430918047940476 no 318 0.0527930901860355 97 65057 A dermal irritant. YDR527W RBA50 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.616806071914 0.0432322919670839 no 319 0.052960074172664 80 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2374 9071832 200 µM 1.61324929050909 0.0435563553740427 no 320 0.0533451793266278 70 17381698 SGTC_790 1575-0012 79.1 µM 1.60870459218268 0.0439732792179519 no 321 0.0538404756004341 83 378741 YLR208W SEC13 SGTC_152 4469-0003 551.229 µM 1.60300883105477 0.0445003377429574 no 322 0.0544663522004871 128 697280 SGTC_949 1165-0505 146 µM 1.60096028096638 0.0446911406622311 no 323 0.054692858335289 67 6244267 SGTC_3226 9131256 49.47 µM 1.60038877703144 0.0447444881907623 no 324 0.0547561816373641 54 17178073 SGTC_3137 9097352 49.47 µM 1.58959333628285 0.0457618648772139 no 325 0.0559632500505928 102 44120435 SGTC_212 3807-4682 38.772 µM 1.58533394208913 0.0461683562069336 no 326 0.0564452405649402 92 3125501 YBL034C STU1 SGTC_1424 4048-1941 275 µM 1.57785786865174 0.0468888359806969 no 327 0.0572991329312223 82 X1424 SGTC_2770 toltrazuril 17.5 µM 1.57491976407683 0.0471744420791617 no 328 0.0576374830117776 70 68591 Kills coccidiodes. SGTC_1992 st073643 23.3 µM 1.57299889411101 0.0473619179498631 no 329 0.0578595371412714 88 3161292 SGTC_1416 3966-0321 25.3 µM 1.56977331449239 0.04767807536852 no 330 0.0582339289624145 92 582530 YLR208W SEC13 SGTC_1007 4101-0031 70 µM 1.56974088680619 0.0476812623509615 no 331 0.0582377024714965 96 1146276 SGTC_907 3448-6986 75.5 µM 1.56902572066604 0.0477515920278077 no 332 0.0583209729761349 106 590582 SGTC_1054 3429-0080 167 µM 1.56240940618983 0.0484061886639478 no 333 0.0590957863080434 84 1162877 SGTC_1825 st052143 62.6 µM 1.55777558012349 0.0488689030170889 no 334 0.0596432283661311 87 674173 SGTC_1903 st060211 78.3 µM 1.55659141331798 0.0489877141822621 no 335 0.0597837618833957 88 688960 SGTC_2918 7977171 22.06 µM 1.55134305685231 0.0495170787748034 no 336 0.0604097467895008 92 2236483 SGTC_2072 5231554 129 µM 1.54791697100512 0.0498650999050264 no 337 0.0608211440417911 94 789545 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.53672313475591 0.0510157847763344 no 338 0.0621805616574135 97 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3265 9137266 49.47 µM 1.53183670842419 0.0515246728422106 no 339 0.0627813675322548 58 17224265 SGTC_2465 5809242 33.21 µM 1.51173068082435 0.0536611834805144 no 340 0.0653011951001209 96 2731748 SGTC_2799 7812892 81.82 µM 1.5097575484821 0.0538745796804086 no 341 0.0655526504315837 124 20205235 SGTC_608 k048-0125 159 µM 1.50117196660844 0.054810951918549 no 342 0.0666555443479563 93 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1227 3909-8010 46.6 µM 1.49594237003919 0.055387583933209 no 343 0.0673343368647832 80 15982272 SGTC_751 0833-0568 350 µM 1.49506177894786 0.0554851502336747 no 344 0.0674491598468448 92 6954252 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.49429826169302 0.0555698549576218 no 345 0.0675488396459113 100 804 An inhibitor of viral and cellular DNA polymerases. SGTC_328 k915-0120 63.5 µM 1.4902215999399 0.0560238491993581 no 346 0.0680829893799653 73 6624543 SGTC_2104 5389443 200 µM 1.48280620917838 0.0568571536004539 no 347 0.0690629529486975 106 2244536 SGTC_910 3454-3003 490 µM 1.48000497947412 0.0571744702462548 no 348 0.0694359588981368 115 820824 SGTC_1970 st070122 35.8 µM 1.4794040186846 0.0572427269096135 no 349 0.0695161833594879 125 102928 SGTC_678 1218-2179 85.9 µM 1.47918698633994 0.0572673930320262 no 350 0.0695451733400786 89 6820081 YOR116C RPO31 SGTC_2962 9082311 13.18 µM 1.47791402970184 0.0574122353211561 no 351 0.0697153953081155 115 16459453 SGTC_802 4112-3352 742 µM 1.476814901996 0.057537530362769 no 352 0.0698626304323203 92 704594 SGTC_2737 bleomycin 30.5 nM 1.47594048893719 0.0576373625965315 no 353 0.0699799344288268 103 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2206 7254556 146.969 µM 1.46466410885994 0.058937033718433 no 354 0.0715062908579969 82 4398905 SGTC_3261 9137475 49.47 µM 1.46309209579197 0.0591200297547226 no 355 0.0717210902046901 45 17027690 SGTC_1877 wortmannin 25 µM 1.45451685358023 0.0601261202906189 no 356 0.072901532169127 100 312145 A covalent inhibitor of PI 3-kinase. SGTC_1626 st003712 1.76 µM 1.45303480202943 0.0603013527402109 no 357 0.0731070457420014 120 24207035 SGTC_1487 3970-0795 2.82 µM 1.45064607094411 0.0605846287426248 no 358 0.0734392197595926 113 3765103 SGTC_2753 fluvastatin 17.09 µM 1.44113811475474 0.061722492578865 no 359 0.0747728337517279 113 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3045 9092950 49.47 µM 1.43788749068364 0.0621153151889882 no 360 0.0752329897980189 80 44120432 SGTC_185 k048-0037 25.491 µM 1.43587791935585 0.0623591363200787 no 361 0.0755185412986979 80 6827589 SGTC_466 geldanamycin 89.2 µM 1.43464314124914 0.0625093216363775 no 362 0.0756944071861491 65 5288382 HSP90 inhibitor. SGTC_2341 7987486 176.74 µM 1.43359294856832 0.0626372777209451 no 363 0.075844228473158 96 1258686 SGTC_1568 digitonin 820 nM 1.43312082020871 0.0626948685938922 no 364 0.0759116562056439 133 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1736 st036774 51 µM 1.42970424165512 0.0631128582690723 no 365 0.0764009611809684 108 1272247 SGTC_591 4299-0174 154 µM 1.42817773800447 0.0633003132054877 no 366 0.076620353293153 92 5509088 SGTC_2761 levamisole 97.89 µM 1.42721832093796 0.0634183514501131 no 367 0.0767584876141846 80 26879 An alkaline phosphatase inhibitor. SGTC_2690 usnic acid 100 µM 1.42643824263963 0.0635144516517068 no 368 0.0768709407222249 99 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_979 1426-2828 121 µM 1.42379477489673 0.0638409513228495 no 369 0.0772529443511518 113 747872 SGTC_1144 3486-0183 12.5 µM 1.41924810621024 0.0644055706437265 no 370 0.0779133477310441 117 6744069 SGTC_67 0335-0847 266 µM 1.41483577265972 0.0649572101640797 no 371 0.0785583264572939 134 4552207 YOR254C SEC63 SGTC_391 gliotoxin 8.33 µM 1.41319775338057 0.065162929896231 no 372 0.0787987934678181 118 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1490 4089-0339 670 nM 1.41068577410515 0.065479392405511 no 373 0.0791686437323393 110 742542 SGTC_644 1498-1197 63.3 µM 1.41016487033372 0.0655451655236504 no 374 0.0792455030731141 114 6741615 SGTC_2457 5731572 11.68 µM 1.40987736251662 0.0655814902982659 no 375 0.0792879490334606 121 2865357 SGTC_1323 1348-1351 11.2 µM 1.40838721275921 0.0657700113600932 no 376 0.0795082217849992 99 6989654 SGTC_2214 7179297 48.276 µM 1.40562500981195 0.0661205724356139 no 377 0.0799177527386299 86 769744 SGTC_2028 5153890 36.43 µM 1.40475543266873 0.0662312326401002 no 378 0.0800470079418743 119 2830968 YPR165W RHO1 SGTC_1002 4049-0206 172 µM 1.40430487737685 0.066288625562425 no 379 0.0801140412613132 115 4662749 SGTC_3148 9097893 49.47 µM 1.40353305566645 0.0663870317414798 no 380 0.0802289709842748 97 17174100 SGTC_1208 2323-2347 50.3 µM 1.40133249984001 0.0666682205324098 no 381 0.0805573334476897 86 5412760 SGTC_946 3434-1334 87.4 µM 1.3894891300619 0.0681974323329549 no 382 0.0823420320125232 123 4047976 SGTC_1216 1165-0504 9.65 µM 1.38850429621789 0.0683258030893772 no 383 0.0824917687263127 121 6304004 SGTC_1430 4049-0248 69.1 µM 1.38462447081001 0.0688333440234222 no 384 0.0830836624418823 119 22774488 SGTC_1365 1672-3266 55.4 µM 1.37577468836916 0.070001904367033 no 385 0.0844457000992064 134 6415873 SGTC_1646 st011709 75.6 µM 1.37471330486429 0.0701430726390087 no 386 0.0846101723738619 125 5757843 SGTC_342 k048-0088 23.3 µM 1.37212811403971 0.0704878295890413 no 387 0.0850117794126921 120 6820570 SGTC_2423 st077119 87.2 µM 1.36900011847221 0.0709067139962993 no 388 0.0854996189384747 112 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2043 5101342 149 µM 1.36477787797649 0.0714751631278196 no 389 0.0861614368992488 119 678451 SGTC_228 caffeine 993.056 µM 1.36051573113799 0.0720525253471952 no 390 0.0868333891102133 73 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1271 0832-2808 169 µM 1.36044023147587 0.0720627848743548 no 391 0.0868453272640884 135 3663794 SGTC_1215 3852-0577 11.2 µM 1.35299648324998 0.0730798123414165 no 392 0.0880283769367964 111 2884876 SGTC_3112 9123419 49.47 µM 1.342646515908 0.0745121189977705 no 393 0.0896932303487057 126 17015854 SGTC_2831 7999036 19.48 µM 1.34253015336687 0.0745283430714834 no 394 0.0897120801132167 121 2988270 SGTC_1175 0741-0056 27.6 µM 1.34156492935541 0.0746630252773346 no 395 0.089868551929619 120 765927 SGTC_2970 9090938 41.86 µM 1.34145408883782 0.0746785032532817 no 396 0.0898865331872985 125 17217104 SGTC_2991 9074669 71.4286 µM 1.3408229969507 0.0747666767621808 no 397 0.0899889639062933 159 17333109 SGTC_558 k064-0027 21.3 µM 1.34034652424191 0.0748333001384902 no 398 0.0900663562743109 131 5088526 SGTC_2487 5918373 44.05 µM 1.33370300356484 0.075766963104666 no 399 0.0911506050245013 143 2876279 SGTC_1925 st057770 10.1 µM 1.33357204332031 0.0757854566853812 no 400 0.091172075113254 112 5989122 SGTC_670 4204-0025 119 µM 1.33296552128852 0.0758711516691498 no 401 0.0912715594000068 101 719039 SGTC_1722 st034304 3.6505 µM 1.33188906103588 0.0760234255063016 no 402 0.0914483230720944 125 4036148 YLR033W RSC58 SGTC_1147 3809-1045 12.3 µM 1.3301491252638 0.0762700450492173 no 403 0.091734571232951 127 325925 SGTC_692 k241-0027 77.8 µM 1.32978096005932 0.0763223069645798 no 404 0.0917952254841208 115 3600480 SGTC_1101 ebselen 5.29 µM 1.32483641378342 0.077026839975478 no 405 0.092612707213651 141 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1486 3970-0793 4.53 µM 1.32427116359058 0.0771076945160078 no 406 0.0927065019331957 133 2844330 SGTC_1666 st014829 29 µM 1.32148447694718 0.0775072508775635 no 407 0.0931699375328875 104 3858230 SGTC_632 0781-2353 4.65 µM 1.32033925974303 0.0776719077106196 no 408 0.0933608866560099 157 6811515 YHR007C ERG11 SGTC_2483 5729050 27.16 µM 1.31655384114076 0.0782180567274458 no 409 0.093994109882983 124 2865180 SGTC_1087 pterostilbene 9.05 µM 1.31499702748692 0.0784435125740175 no 410 0.0942554507412651 136 5281727 Similar to reservatol, lowers cholesterol. SGTC_1495 4469-0029 237 µM 1.31417964958108 0.0785620813134055 no 411 0.0943928775916208 121 793680 SGTC_1491 4138-0063 26.5 µM 1.31135539129617 0.078972813595333 no 412 0.0948688612302132 112 23883227 SGTC_1064 honokiol 6.76 µM 1.30612373089459 0.0797379487316421 no 413 0.0957552420198157 141 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1887 st057648 70.8 µM 1.30550754159315 0.0798284348496276 no 414 0.0958600404155473 146 688672 SGTC_2381 9035592 200 µM 1.30025999025669 0.0806021761817052 no 415 0.0967559379504002 116 4749657 SGTC_597 k018-0003 82.8 µM 1.29831903853869 0.0808897963515248 no 416 0.097088863423943 123 6786234 SGTC_530 4358-1714 28 µM 1.29507910916351 0.0813716308233447 no 417 0.0976464703784258 145 1564641 SGTC_964 1287-0107 19.4 µM 1.29243056563111 0.0817671215014707 no 418 0.0981040386181974 131 51516812 YPR165W RHO1 SGTC_1272 0839-0021 27 µM 1.2912969439254 0.0819368403625997 no 419 0.0983003649745506 130 5027250 SGTC_2580 diallyl disulphide 81.36 µM 1.28364381472071 0.0830895716147081 no 420 0.0996333058601358 131 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1157 4092-0394 27.6 µM 1.28032011876663 0.0835939757834756 no 421 0.100216287424219 119 3659885 SGTC_3169 9102970 49.47 µM 1.27597410602218 0.0842569934494182 no 422 0.100982336349088 120 17027839 SGTC_3297 9117502 71.43 µM 1.27485362156004 0.0844285702101552 no 423 0.101180528627753 93 7453720 SGTC_1521 st012942 49.4 µM 1.2707565974079 0.0850581684414593 no 424 0.101907626904554 118 24207259 SGTC_3125 9127534 49.47 µM 1.2694330439195 0.0852623118178664 no 425 0.102143328486124 108 1639235 SGTC_439 amiodarone 34.4 µM 1.26813652412657 0.0854626412415403 no 426 0.102374600129899 124 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2811 7967822 32.47 µM 1.26628639465213 0.0857491208291498 no 427 0.102705283064108 116 2232244 SGTC_1035 k081-0041 55.2 µM 1.26521634872961 0.0859151377292824 no 428 0.102896891726022 125 731709 SGTC_2022 5136654 200 µM 1.25695532798621 0.0872049345878698 no 429 0.104384906040258 148 1713771 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.25348112937471 0.0877516609975525 no 430 0.105015331214473 118 364106 SGTC_743 1275-0778 158 µM 1.24687594628833 0.0887981481868635 no 431 0.106221493867279 158 2849257 YMR203W TOM40 SGTC_2190 6049624 200 µM 1.24596428511987 0.0889433133199854 no 432 0.106388753673396 130 2265554 SGTC_2331 7980721 200 µM 1.24521250882655 0.0890631525991609 no 433 0.106526822879072 151 2981221 SGTC_2484 5809818 12.04 µM 1.24425970249636 0.0892152103336409 no 434 0.10670199852525 128 2870548 SGTC_2719 novobiocin 32.65 µM 1.24242695826452 0.0895082397810034 no 435 0.107039537143234 128 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3198 9112019 49.47 µM 1.2395739328368 0.0899658210308641 no 436 0.10756651359334 154 45595555 SGTC_1805 st050013 60.3 µM 1.23849141410292 0.0901398944896509 no 437 0.107766951854676 137 4037144 SGTC_266 formosanin C 406 nM 1.23363294519832 0.0909242385423163 no 438 0.108669855422681 157 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.23006189759679 0.091503963655193 no 439 0.109336963444443 122 5357218 A potent inhibitor of glutathione S-transferases. SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.22901966673902 0.0916736751069895 no 440 0.109532216213903 147 5282309 SGTC_2694 st077685 81.9 µM 1.22885392865104 0.0917006845128987 no 441 0.109563288844919 124 2838096 SGTC_1691 st019933 84.6 µM 1.22669620613486 0.0920528546110399 no 442 0.109968397093135 144 6176082 SGTC_934 2950-0684 338 µM 1.22648489887116 0.0920873966362423 no 443 0.110008127331771 150 1121253 SGTC_3186 9110464 49.47 µM 1.2222147676953 0.0927874852420479 no 444 0.110813210361722 115 17018021 SGTC_815 1582-0027 36.9 µM 1.22153765215959 0.092898859002991 no 445 0.110941259317363 151 3128206 SGTC_426 0988-0037 14.6 µM 1.21855691152289 0.0933903144781939 no 446 0.111506205823412 162 5383008 SGTC_1471 k673-0312 37 µM 1.21647744970695 0.093734305359117 no 447 0.111901548098158 139 24099884 SGTC_1409 3909-8004 61.9 µM 1.21590465170881 0.0938292234564722 no 448 0.112010622938821 133 2119279 SGTC_581 0958-0271 211 µM 1.21158008592016 0.0945481361340417 no 449 0.112836580658366 111 4591145 SGTC_972 1319-0219 195 µM 1.21131514874195 0.0945923107444368 no 450 0.112887322534956 153 23903702 SGTC_1982 st072467 71.9 µM 1.20985389539939 0.0948362279268536 no 451 0.11316748057311 146 3163533 SGTC_373 0844-0104 25.9 µM 1.20680638743721 0.0953464184980213 no 452 0.113753357797856 153 5375804 SGTC_352 k048-0007 5.11 µM 1.20004110358478 0.0964862270687334 no 453 0.11506168867558 173 6811911 SGTC_3017 9080681 49.47 µM 1.19882649784786 0.0966919183338107 no 454 0.115297708447151 139 16451914 SGTC_75 0159-0059 199.013 µM 1.19819487400308 0.0967990098806552 no 455 0.115420580252209 162 5377270 SGTC_2157 5649910 96.377 µM 1.19527107852907 0.097295873000395 no 456 0.115990567839314 138 2858091 SGTC_759 3486-0358 89.3 µM 1.190717481417 0.0980734233218614 no 457 0.116882256405099 156 875103 SGTC_1596 piperlongumine 63 µM 1.19014757279906 0.0981710578414355 no 458 0.116994197489439 123 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1791 st048313 56.1 µM 1.1801850326021 0.0998893184066688 no 459 0.118963315311685 118 1204976 SGTC_161 4065-0411 162.148 µM 1.17895900885292 0.100102281941786 no 460 0.119207249361923 159 1906281 YLR208W SEC13 SGTC_104 0074-0074 590.992 µM 1.17893181005888 0.100107010199222 no 461 0.119212664930974 140 3943124 SGTC_2245 6637752 200 µM 1.17526397339089 0.1007461239925 no 462 0.119944561542611 130 681890 SGTC_2975 9084847 53.72 µM 1.17226616337007 0.101270692784744 no 463 0.120545106015398 142 27211724 SGTC_2643 anethole 100 µM 1.16910727912541 0.101825597370965 no 464 0.121180205768649 164 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.16811596412079 0.102000191888215 no 465 0.12137999585955 157 5106787 A p450 inhibitor. SGTC_2241 6772625 37.8075 µM 1.16684334883046 0.102224649386188 no 466 0.121636818687798 149 2285411 SGTC_567 1080-0542 68.4 µM 1.16477429235234 0.10259034574263 no 467 0.122055183748544 123 5950415 SGTC_1765 st044815 90.4 µM 1.16093666886992 0.103271144282959 no 468 0.122833827649255 166 645695 SGTC_2089 5281248 129.67 µM 1.15828948385704 0.103742665694093 no 469 0.123372960716852 146 2737878 SGTC_2978 9011784 42.97 µM 1.15552727465461 0.104236338492483 no 470 0.123937285052597 128 2994934 SGTC_288 1315-0019 35.1 µM 1.15455270047238 0.104410923926468 no 471 0.124136822800905 182 6811474 SGTC_1433 4060-0023 7.6 µM 1.15334985388621 0.104626694148197 no 472 0.124383407586844 155 3840627 SGTC_2393 9031399 185.94 µM 1.1523682048409 0.104803024499976 no 473 0.124584900329879 158 1526623 YDL150W RPC53 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.14762284788125 0.105658451890645 no 474 0.12556214675919 156 688662 SGTC_2276 7947513 42.08 µM 1.14428410766849 0.106263331873988 no 475 0.126252915958762 143 2105100 SGTC_728 3030-5151 22.5 µM 1.14323558777439 0.106453807424449 no 476 0.126470395114513 141 3125388 SGTC_2983 9022671 12.99 µM 1.14142579270211 0.106783156994946 no 477 0.126846388181213 142 6405161 SGTC_1211 1056-0033 32.3 µM 1.13974047415222 0.107090514690242 no 478 0.127197219816058 154 6741922 SGTC_78 0336-0123 156.75 µM 1.13341227395026 0.108250306684395 no 479 0.128520581056249 142 6765896 SGTC_2368 9071271 200 µM 1.13068365784954 0.1087531695131 no 480 0.129094131042307 150 27209959 SGTC_2005 4024620 188 µM 1.12826545659002 0.109200227418644 no 481 0.129603913666539 153 236743 SGTC_467 ro 31-8220 72.8 µM 1.12473089942724 0.10985604155679 no 482 0.130351541894202 158 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2461 5755302 26.15 µM 1.12392117983671 0.110006676902555 no 483 0.130523232654864 158 2788904 SGTC_894 0960-0238 55.9 µM 1.12374971784858 0.110038593660976 no 484 0.1305596090474 178 6741907 YDL195W SEC31 SGTC_565 1418-0001 44.5 µM 1.12350773073046 0.110083649610103 no 485 0.13061095957476 157 2862145 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.12271464072276 0.110231409009265 no 486 0.130779353970849 194 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2849 9019321 12.99 µM 1.11673583020437 0.111349891752005 no 487 0.132053646545896 149 16489627 SGTC_497 capsazepine 133 µM 1.11546477977761 0.111588716246193 no 488 0.132325651555342 145 2733484 A calcium channel blocker. SGTC_449 xestospongin c 11.1929 µM 1.11311019694545 0.112032099333653 no 489 0.132830552402976 147 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2099 5377090 177.372 µM 1.11269597964771 0.112110229211174 no 490 0.13291951139826 170 2243829 SGTC_2149 5554786 194.827 µM 1.11264031064195 0.112120732495709 no 491 0.132931470226959 151 745063 YPR165W RHO1 SGTC_1162 k048-0130 20.1 µM 1.11237717640754 0.112170388559781 no 492 0.132988006809895 162 6797406 SGTC_1016 4226-1401 38 µM 1.10968657275157 0.112679034676668 no 493 0.133567055448867 168 2901613 SGTC_2884 9058502 51.95 µM 1.10867289813847 0.112871091672004 no 494 0.133785658792691 142 6471554 SGTC_1408 3909-7976 48.8 µM 1.10793759995353 0.113010551926573 no 495 0.133944382868135 159 24152374 SGTC_2730 imipramine 71.33 µM 1.1065941337705 0.113265677833619 no 496 0.134234722357351 148 3696 A tricyclic antidepressant. SGTC_3272 9137413 49.47 µM 1.10606030962178 0.113367165686494 no 497 0.134350208204153 167 17614870 SGTC_111 0083-0039 52.457 µM 1.10560791680482 0.113453222999995 no 498 0.134448130845427 133 759313 SGTC_3195 9113082 49.47 µM 1.1006823471546 0.11439321511074 no 499 0.135517465918139 151 17018038 SGTC_1378 2093-0007 380 nM 1.0986288114065 0.11478674361218 no 500 0.135965002664294 176 3618014 SGTC_1136 pergolide 1.05886 µM 1.09783522959956 0.114939079071386 no 501 0.136138222465933 176 47811 A dopamine receptor agonist. SGTC_3196 9111891 49.47 µM 1.09539738077409 0.115407946155965 no 502 0.13667129055192 164 18891510 SGTC_3130 9127414 49.47 µM 1.08531893322069 0.117360737078794 no 503 0.138890211568438 161 1494646 SGTC_2146 5545642 200 µM 1.084430604562 0.117533974337 no 504 0.139086960139818 156 825326 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.0817960807227 0.118048809913474 no 505 0.139671574255846 200 368090 SGTC_1340 1486-1359 257 µM 1.08165323000085 0.118076771154017 no 506 0.139703321233658 169 4309068 SGTC_1028 k015-0029 4.8 µM 1.08145884868549 0.118114826386406 no 507 0.139746528189923 162 4588309 SGTC_1965 Pectolinarigenin 58.4 µM 1.08093967165676 0.118216511406021 no 508 0.139861975065151 150 5320438 An anti-inflammatory. SGTC_937 3122-0005 46.7 µM 1.0772380898665 0.118943290270817 no 509 0.140686956326481 174 759535 SGTC_2620 irigenin 100 µM 1.07470508274633 0.119442442808216 no 510 0.141253393710266 177 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2258 7960471 200 µM 1.0711741253606 0.120140713981335 no 511 0.142045571759044 154 2974708 SGTC_1493 4348-0038 111 µM 1.06760218256391 0.120850012129801 no 512 0.142849999351095 202 800424 SGTC_1498 4478-3555 97.6 µM 1.06588339050347 0.121192369309585 no 513 0.143238179071815 141 3437919 SGTC_1602 st001878 87.6 µM 1.06575463553249 0.121218042773507 no 514 0.143267286329002 186 595405 YLR310C CDC25 SGTC_3162 9099653 49.47 µM 1.06509064242448 0.121350502295574 no 515 0.143417456712489 142 25237511 SGTC_568 1193-0097 7.48 µM 1.06334771494865 0.121698681779629 no 516 0.143812147124 182 3646150 SGTC_2871 9038510 12.99 µM 1.06157705753683 0.122053119019373 no 517 0.144213866790463 204 4945164 SGTC_257 daunorubicin 18.5 µM 1.05947695054133 0.122474442059686 no 518 0.144691310515293 164 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3111 9122088 49.47 µM 1.05705528058194 0.122961542674631 no 519 0.145243179437029 144 16876704 SGTC_86 0417-1630 471.922 µM 1.05497675170502 0.123380704913677 no 520 0.145717978754915 196 3634867 SGTC_1694 st024011 44.9 µM 1.0540795234458 0.123561951568231 no 521 0.14592325507479 178 2787533 SGTC_1228 0124-0032 52.5 µM 1.05230496162913 0.123920974919895 no 522 0.146329828011437 148 X1228 SGTC_2557 derrustone 83.84 µM 1.04852538085118 0.124688078818109 no 523 0.147198307431545 176 629853 An antioxidant. SGTC_397 arbidol 50 µM 1.04435849888006 0.125537628804754 no 524 0.148159778500566 167 131410 A RNA synthesis inhibitor. SGTC_2820 7989630 71.43 µM 1.04400001380155 0.125610905518897 no 525 0.148242691623234 122 2984098 SGTC_725 1497-0963 19 µM 1.0438256511082 0.125646557189258 no 526 0.148283030756247 167 3549977 SGTC_2592 piperlongumine 83.33 µM 1.04214494010769 0.125990571598978 no 527 0.148672242884239 185 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_389 tpck 16.7 µM 1.03989626528667 0.126451865399159 no 528 0.149194048894036 149 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1625 st003711 30.1 µM 1.03928315776181 0.126577842345365 no 529 0.149336532708714 165 24207034 YER133W GLC7 SGTC_1730 st033808 45.1 µM 1.03453610482717 0.127556191638174 no 530 0.150442803527424 172 1045166 SGTC_148 3253-0744 288.01 µM 1.03341200883169 0.127788631358187 no 531 0.150705564488956 181 6893655 SGTC_1953 st076800 12.1 µM 1.03075903661429 0.128338377668135 no 532 0.151326916088621 186 297591 SGTC_2365 9042475 200 µM 1.0273490582227 0.129047398723872 no 533 0.152128064820505 179 6464479 SGTC_3138 9097216 49.47 µM 1.02583562938698 0.12936294763188 no 534 0.152484534312392 200 25237486 SGTC_2051 5263410 176 µM 1.02403136699933 0.129739833351362 no 535 0.152910229800292 174 227584 SGTC_8 0354-0001 70 µM 1.02244045498918 0.130072783369501 no 536 0.153286240774258 191 4993152 SGTC_3232 9132874 49.47 µM 1.02225382752964 0.130111879948168 no 537 0.153330390162167 175 3784940 SGTC_48 0382-0018 55 µM 1.02170938062385 0.130225982574089 no 538 0.153459234977127 150 762596 SGTC_1402 3909-7673 35.9 µM 1.02096805828558 0.130381456715246 no 539 0.153634786155136 175 5328014 SGTC_1705 st027868 56.3335 µM 1.01629723772094 0.131363999341728 no 540 0.154743931801737 167 292948 SGTC_1768 st044301 37.178 µM 1.01625054419552 0.131373847420785 no 541 0.154755046414072 224 3931349 SGTC_2682 pyrogallin 40.03 µM 1.01577162982541 0.131474884140105 no 542 0.154869074412219 170 822798 An ATP competetive kinase inhibitor. SGTC_3047 9092122 49.47 µM 1.01465903019747 0.1317098166697 no 543 0.155134195047128 175 17173831 SGTC_1252 0493-0875 34.8 µM 1.01134000887849 0.132412369568124 no 544 0.155926861643996 154 3960963 SGTC_3097 9117246 49.47 µM 1.00578126835826 0.133594790411524 no 545 0.157260399917154 172 16423892 SGTC_2791 5663188 71.43 µM 1.00452070592703 0.133863936290217 no 546 0.157563847986024 200 54690634 SGTC_58 0957-0393 9 µM 1.00411821997483 0.133949950524692 no 547 0.157660817134398 208 6997992 SGTC_1117 retinoic acid 1.10837 µM 1.00169979037422 0.134467586562238 no 548 0.158244303984381 175 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1383 3049-0032 20.7 µM 1.00004035452314 0.134823562482539 no 549 0.158645489515278 201 712864 SGTC_378 3970-0959 8.33 µM 0.9987731780259 0.135095827398341 no 550 0.15895229102746 192 6615653 SGTC_3060 1327-0027 12.5 µM 0.997740375738646 0.135318013484379 no 551 0.159202634589971 182 16000455 YPR107C YTH1 SGTC_1401 3807-4679 7.6 µM 0.99743302772037 0.135384181397672 no 552 0.159277183287399 192 3291456 SGTC_2641 levomentholum 100 µM 0.99697340210544 0.13548317400999 no 553 0.159388710276725 178 16666 SGTC_3073 9114972 49.47 µM 0.993235786934803 0.1362900105441 no 554 0.160297531059616 159 41905075 SGTC_1059 3448-6867 171 µM 0.992950034858304 0.136351830658786 no 555 0.16036715227025 195 3934407 SGTC_430 0958-0115 16.4 µM 0.992851579838652 0.13637313503658 no 556 0.160391144625558 174 6833180 SGTC_2412 st077135 33.4 µM 0.991772138464415 0.136606861376839 no 557 0.16065434588732 190 13258915 SGTC_2178 5812956 200 µM 0.991156375655363 0.136740312216786 no 558 0.160804614225811 197 5403383 SGTC_418 lividomycin a 100 µM 0.990662105268675 0.136847497144983 no 559 0.160925300404765 172 72394 An antibiotic. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.989767746142693 0.137041589191189 no 560 0.161143826638028 186 4213774 SGTC_1988 st071872 53.4 µM 0.988633394086593 0.137288034484853 no 561 0.161421270738431 164 16414116 SGTC_1874 staurosporine 7.6 µM 0.988485116468209 0.137320271107304 no 562 0.161457560043901 200 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.987648678290698 0.137502215617275 no 563 0.161662368663632 177 4330530 SGTC_1008 4106-0037 6 µM 0.986570214030165 0.137737049155251 no 564 0.161926689132279 210 2905394 SGTC_154 3389-1638 511.116 µM 0.985404203410504 0.137991253487647 no 565 0.162212782881612 186 5238686 SGTC_182 3448-4371 550.524 µM 0.983525576551163 0.138401489466154 no 566 0.16267441684843 165 3491403 SGTC_2252 omeprazole 400 µM 0.983315812293567 0.138447347246829 no 567 0.162726015093049 162 4594 A proton pump inhibitor. SGTC_574 1315-0397 40 µM 0.982590293216291 0.138606037017273 no 568 0.162904561844787 224 6794277 SGTC_502 l-744,832 89.3 µM 0.981493878262461 0.138846086357652 no 569 0.163174625891062 180 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2469 5655019 90.81 µM 0.980426316481357 0.139080090459667 no 570 0.163437862353955 175 2788239 SGTC_951 1171-0579 82.7 µM 0.979224814764571 0.139343774423869 no 571 0.16373445507228 192 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3074 9116018 49.47 µM 0.976467690573341 0.139950143479061 no 572 0.164416375694786 209 17027303 SGTC_1251 0490-5699 265 µM 0.973892176257487 0.140518189061942 no 573 0.165055039397778 200 3883818 SGTC_2366 9070441 60.58 µM 0.973573956444704 0.140588482895406 no 574 0.16513406135896 177 6837235 SGTC_2819 7996655 46.38 µM 0.971974039701132 0.140942261500767 no 575 0.165531731832738 167 6456960 SGTC_841 0251-0215 91.2 µM 0.970788093391826 0.141204891058919 no 576 0.165826906473395 192 3888614 SGTC_2387 9077560 195.08 µM 0.96422347211958 0.142664635386579 no 577 0.167466949454257 186 5303272 SGTC_1420 4'-methoxyflavone 42 µM 0.963413380895746 0.142845476308056 no 578 0.167670056944717 183 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1844 rapamycin 4 nM 0.960719679501857 0.143447919224166 no 579 0.168346566755442 209 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2651 TUB2.036 5 µM 0.96028789049682 0.143544647577051 no 580 0.168455171463665 204 15992207 YFL037W TUB2 SGTC_2977 9011197 71.43 µM 0.957705875852782 0.14412398308386 no 581 0.169105546500658 205 2704722 SGTC_3039 9090270 49.47 µM 0.95450834564211 0.144843606211771 no 582 0.169913193441183 170 17173750 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.951164995390562 0.145598630290005 no 583 0.170760312471226 185 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_690 glyoxal 20.3 µM 0.948973272424256 0.146095017518424 no 584 0.171317102958258 201 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_94 0334-0113 514.748 µM 0.944216527200185 0.147176244833764 no 585 0.172529505635621 209 6795178 SGTC_881 0833-0569 170 µM 0.94405079331772 0.147214013271581 no 586 0.172571846414729 182 5418700 SGTC_1777 st045864 34.765 µM 0.941835538976488 0.147719462585527 no 587 0.173138423440737 239 4691462 SGTC_145 3737-0113 38.366 µM 0.939692314781664 0.148209581824348 no 588 0.17368770417639 222 6849351 SGTC_1761 st044296 37 µM 0.935463772127197 0.14917976586531 no 589 0.174774672525941 204 1826700 SGTC_656 4090-1979 187 µM 0.932046229024567 0.149966968945582 no 590 0.175656317441389 202 22330961 SGTC_753 1322-0200 289 µM 0.931048770874556 0.15019724652351 no 591 0.175914168282367 189 5403907 SGTC_532 1548-0774 215 µM 0.930199134909245 0.150393583003159 no 592 0.176133994864738 201 5932993 SGTC_1477 0139-0234 16 µM 0.930015773644218 0.15043597710931 no 593 0.17618145878557 200 620880 SGTC_3262 9137218 49.47 µM 0.928724403607243 0.150734774245008 no 594 0.176515965199634 153 17650664 SGTC_3182 9108849 49.47 µM 0.928398180032365 0.150810318317579 no 595 0.176600531123024 203 17133045 SGTC_957 1187-1561 14.1 µM 0.927040611353697 0.151124963148314 no 596 0.176952724524271 209 1538454 SGTC_730 1436-0052 41.2 µM 0.924715150349025 0.151664951384828 no 597 0.17755704828949 177 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3008 9078912 71.4286 µM 0.91770650910156 0.15330015485238 no 598 0.179386269507296 210 16648731 SGTC_2144 5628481 200 µM 0.917030313231636 0.153458535353098 no 599 0.179563377884425 191 2818399 SGTC_541 4513-1321 94 µM 0.91047845371454 0.154998741369296 no 600 0.181285119834527 215 747515 SGTC_1984 st072354 53.1 µM 0.90991036800881 0.155132765791796 no 601 0.18143489073995 223 5762938 SGTC_1341 1486-1360 280 µM 0.909875677630257 0.155140952524194 no 602 0.181444039068438 224 3976547 SGTC_1360 1598-0022 39.8 µM 0.904060179712989 0.156517408942005 no 603 0.182981745865239 220 761525 SGTC_2160 5660466 132.927 µM 0.899575546908928 0.157584340704149 no 604 0.184173087625037 215 2859134 SGTC_2187 6125751 200 µM 0.897650083971289 0.158043887383593 no 605 0.184686064438344 214 874498 SGTC_90 0870-0863 4.608 µM 0.895583372901242 0.158538123434779 no 606 0.185237659625526 237 1738164 SGTC_221 trifluoperazine 10.304 µM 0.889716864380012 0.159946564513566 no 607 0.186808968130174 245 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1588 farnesol 29.9 µM 0.888869404655208 0.160150698448082 no 608 0.1870366350395 206 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1744 st037937 38.9 µM 0.887244320668515 0.160542620771676 no 609 0.187473687714428 217 1016152 SGTC_2886 9058944 51.95 µM 0.886945863377122 0.160614667910471 no 610 0.187554023844633 164 4949929 SGTC_1583 clindamycin 39.6 µM 0.883966884824628 0.16133494598664 no 611 0.188357044667412 220 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1451 4152-0210 104 µM 0.882253887353216 0.161750078938874 no 612 0.188819763448401 212 659563 SGTC_300 r073-0011 5.04 µM 0.880757928060816 0.162113183112568 no 613 0.189224427839874 203 2735780 SGTC_2134 5324836 1.464 µM 0.879555983369337 0.162405307375061 no 614 0.189549946380403 216 699272 SGTC_32 0928-0142 34.1 µM 0.876950513250802 0.163039724217634 no 615 0.190256758879041 226 2244242 SGTC_6 0844-0013 19.835 µM 0.874602548935126 0.163612818004084 no 616 0.190895100202568 246 1584900 SGTC_3341 9147222 25.867 µM 0.873778192576365 0.163814337683712 no 617 0.191119529330446 219 1939759 SGTC_69 0096-0274 206.684 µM 0.873129581652915 0.163973008352588 no 618 0.191296225844573 266 6741392 SGTC_2084 5306078 60.6385 µM 0.871280478614832 0.164425904380592 no 619 0.191800513364588 228 679340 SGTC_2777 climbazole 1.536 µM 0.869120936299154 0.164955861009121 no 620 0.192390493207247 229 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_59 0330-0160 1.33 µM 0.867206495367621 0.165426593042931 no 621 0.192914438998767 208 4293482 SGTC_2282 7944268 200 µM 0.866613786880865 0.165572507088835 no 622 0.193076828463658 213 2970414 SGTC_522 1273-0010 11.6 µM 0.866456306490752 0.165611289887699 no 623 0.193119988756106 221 5705015 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.864253923261477 0.16615428776102 no 624 0.193724207938981 210 2724278 An inhibitor of dopamine biosynthesis. SGTC_1763 st044482 94.5 µM 0.863907332735932 0.166239844320694 no 625 0.193819399171406 240 88505 SGTC_1620 st003704 16.5 µM 0.861844511916604 0.166749644262521 no 626 0.194386543402789 212 2834414 SGTC_199 4063-0024 41.6 µM 0.861751773971804 0.166772586936015 no 627 0.194412064135389 206 306215 SGTC_1079 idarubicin 2.36 µM 0.861292389431683 0.166886265263281 no 628 0.194538513121282 241 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2532 xanthone 78.9 µM 0.860714162001535 0.167029423235064 no 629 0.194697745623438 194 7020 An insecticide. SGTC_3325 9138760 55.175 µM 0.859007163179109 0.167452505072813 no 630 0.195168282008391 213 43844959 SGTC_3185 9108267 49.47 µM 0.857599216069013 0.167801985726755 no 631 0.195556904041704 232 4910486 SGTC_493 zm226600 134 µM 0.857515855827109 0.167822692122344 no 632 0.195579927888198 227 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2861 9024595 19.48 µM 0.856120962962835 0.168169422740365 no 633 0.195965437236841 189 16482810 SGTC_1293 1000-1278 195 µM 0.855134670211803 0.168414864968915 no 634 0.196238298969731 225 678847 SGTC_485 niflumic acid 177 µM 0.854446502756575 0.168586254094211 no 635 0.196428819544096 221 4488 A COX2 inhibitor. SGTC_1262 0737-0114 49.6 µM 0.854120368243774 0.168667517523803 no 636 0.196519149693373 230 765919 SGTC_1203 3992-3522 103 µM 0.852829470473097 0.168989419475243 no 637 0.196876939231252 237 5322312 SGTC_1904 st060225 78 µM 0.851015958181258 0.169442308188697 no 638 0.197380244061196 208 66595 SGTC_1641 st009299 47.1 µM 0.850915084043481 0.169467522349626 no 639 0.197408262529828 219 4046054 SGTC_653 0203-0016 55.2 µM 0.849710324806042 0.169768846001401 no 640 0.197743078361818 224 295302 SGTC_766 1391-0721 126 µM 0.842816032738636 0.171499788561929 no 641 0.199665669934666 243 1020919 YIL115C NUP159 SGTC_3096 9117468 49.47 µM 0.84039362931315 0.172110646996266 no 642 0.200343859963374 218 41316311 SGTC_968 1309-0633 340 µM 0.835954396140674 0.173233689602973 no 643 0.201590279458755 232 3761976 SGTC_2608 thymoquinone 42.66 µM 0.832338977141221 0.174151762444272 no 644 0.202608817909593 230 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2192 5915882 198.485 µM 0.830877047405594 0.174523870530395 no 645 0.203021545618475 211 2876149 SGTC_2957 9076800 11.52 µM 0.830429782541142 0.174637814609422 no 646 0.203147916346569 220 16459615 SGTC_2132 5317594 122.667 µM 0.830385273843623 0.174649156117561 no 647 0.203160494453472 246 794577 SGTC_2115 tiliquinol 12.7705 µM 0.827525538956631 0.175378841217913 no 648 0.20396962642257 233 71208 A bioactive hydroxyquinoline. SGTC_916 4466-0038 42 nM 0.827471341877414 0.175392688688492 no 649 0.203984979434172 248 5722064 YGL116W CDC20 SGTC_3031 9088762 49.47 µM 0.826246339152465 0.17570586440443 no 650 0.204332183267485 233 205253 SGTC_290 2043-6722 48.1 µM 0.825935771347956 0.175785318280073 no 651 0.204420263708491 225 773758 YLR208W SEC13 SGTC_310 1273-0058 1.06 µM 0.825081946608581 0.176003873149643 no 652 0.204662534232231 196 2734232 SGTC_3080 9117754 49.47 µM 0.824877506031116 0.176056229646829 no 653 0.204720569044983 230 9550191 SGTC_1997 st073024 93.8 µM 0.82391955161758 0.176301689658425 no 654 0.204992635179727 231 686268 SGTC_1196 1588-0294 184 µM 0.823678232477126 0.176363557836736 no 655 0.205061205476579 224 6144269 SGTC_2797 7859098 81.82 µM 0.821728793831608 0.17686384861957 no 656 0.205615633845116 232 972681 SGTC_222 nsc-310342 10.666 µM 0.819045362265628 0.177553971948544 no 657 0.206380266538606 225 432556 SGTC_2441 5730946 39.09 µM 0.818360490297355 0.1777303787852 no 658 0.206575687524355 222 1774275 SGTC_1830 st055982 50.3 µM 0.817508086486207 0.177950092266069 no 659 0.206819064985939 239 455313 An antimicrobial agent. SGTC_249 wiskostatin 11.211 µM 0.815822540706194 0.178385058307843 no 660 0.207300819658094 217 2775510 A n-wasp and actin depolymerizer. SGTC_1449 4112-4002 201 µM 0.813450700562424 0.178998260497377 no 661 0.207979850358676 215 2059539 SGTC_370 0180-0345 38.7 µM 0.81169492870623 0.179453041140216 no 662 0.208483352505994 213 3989527 SGTC_603 3794-0023 45.9 µM 0.809829222278367 0.179937092329479 no 663 0.209019167471371 241 3802260 SGTC_189 3970-0742 2.116 µM 0.808518956730334 0.180277525925829 no 664 0.209395948876716 229 2891807 SGTC_2656 pseudo-anisatin 100 µM 0.807676459708483 0.180496637121988 no 665 0.209638429215726 269 6708809 A neurotoxin. SGTC_2512 diallyl trisulfide 49.23 µM 0.805271374874899 0.181123054681841 no 666 0.210331548248328 274 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_201 4262-0159 12.803 µM 0.804295565526154 0.181377597487681 no 667 0.210613149047935 223 1341029 SGTC_2906 7926292 26.41 µM 0.803044324496127 0.181704315020441 no 668 0.210974557915743 243 2966319 SGTC_3309 9129340 25.759 µM 0.802910947336591 0.181739163473099 no 669 0.211013104050358 235 17158987 SGTC_709 3807-1509 243 µM 0.799851915272714 0.182539567164299 no 670 0.211898300018996 264 1886677 YPL242C IQG1 SGTC_1812 st052057 4.327 µM 0.799326326345293 0.182677310181402 no 671 0.212050608734169 235 3645418 SGTC_333 3486-0131 40.1 µM 0.799130767125485 0.182728577664738 no 672 0.212107295545509 230 6744690 SGTC_640 3381-0960 37.1 µM 0.796047648016044 0.183538029905695 no 673 0.21300217060668 242 1745025 SGTC_1540 guanosine 70.6 µM 0.795807990769292 0.183601043779974 no 674 0.213071823252239 237 6802 Guanosine is a purine nucleoside SGTC_3029 9088683 49.47 µM 0.795116032381416 0.183783058338722 no 675 0.213273004729814 224 25236615 SGTC_2342 7990637 118.86 µM 0.794668979782246 0.183900711980047 no 676 0.213403040643943 250 2033102 YER133W GLC7 SGTC_1876 myriocin 605 nM 0.793437865771295 0.184224954366305 no 677 0.213761378317036 260 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_20 0481-0013 4.944 µM 0.79268841906854 0.184422512617859 no 678 0.213979689630779 245 182045 SGTC_2693 st077581 40.7 µM 0.79217304352309 0.184558444878811 no 679 0.214129892085184 248 25238761 SGTC_1983 st071813 46.9 µM 0.791326739417817 0.184781795934326 no 680 0.214376674310256 232 11838595 SGTC_2400 5203494 178.7 µM 0.79126681290104 0.184797617716812 no 681 0.21439415514746 260 6777674 SGTC_2654 protoveratrine a 100 µM 0.789413370431627 0.185287378798726 no 682 0.214935221904048 259 5702278 A heart drug and vasodilator. SGTC_2327 6189656 200 µM 0.788522462437798 0.185523082453087 no 683 0.21519558246108 239 5349088 SGTC_1038 k292-0204 154 µM 0.788474331391621 0.185535821570673 no 684 0.215209653574824 247 4454212 SGTC_2840 9008771 71.43 µM 0.78729264423078 0.185848755688374 no 685 0.215555287343741 191 2992978 SGTC_2475 5812728 15.03 µM 0.78684266532403 0.185968005005041 no 686 0.215686987056111 236 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1802 st050112 57.9 µM 0.7858694906721 0.186226069106875 no 687 0.215971975056504 241 4662563 SGTC_112 phenothiazine 287.218 µM 0.785834863476033 0.186235255549744 no 688 0.215982119428123 237 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2973 9094665 17.96 µM 0.784316589812881 0.186638322930238 no 689 0.216427183699646 256 25237061 YIL048W NEO1 SGTC_2958 9077254 16.72 µM 0.784303113895988 0.186641902898471 no 690 0.216431136382902 233 16457351 SGTC_3354 9151612 71.43 µM 0.782325393864113 0.18716775846908 no 691 0.217011683378407 226 27261949 SGTC_1817 st052116 64.4 µM 0.781679622181873 0.187339660812033 no 692 0.217201440226748 227 4361398 SGTC_313 3474-0040 5.03 µM 0.780486099768449 0.18765762943498 no 693 0.217552403102568 254 1043375 YIL048W NEO1 SGTC_986 1493-0483 84 µM 0.780245675106853 0.187721721758664 no 694 0.217623141094006 245 40079 SGTC_139 0099-0334 718.624 µM 0.780118607381656 0.187755600890153 no 695 0.217660532451451 258 97690 SGTC_1607 st000305 50.6 µM 0.778551825407667 0.188173650739999 no 696 0.218121883309376 237 5457690 SGTC_3269 9137823 49.47 µM 0.777163964870406 0.188544440007528 no 697 0.21853101972752 206 17682936 SGTC_695 3505-6186 243 µM 0.776452017884645 0.188734822803051 no 698 0.218741070564257 257 1819379 SGTC_1126 isoteolin 1.0172 µM 0.774072062992057 0.189372109693381 no 699 0.219444088616787 232 133323 SGTC_1415 3966-0071 78.1 µM 0.77399499483138 0.189392768556124 no 700 0.219466875560976 245 2893185 SGTC_3176 9106582 49.47 µM 0.772461094385293 0.189804233842609 no 701 0.219920690596579 205 17018027 SGTC_2525 harmine 47.85 µM 0.769935146032799 0.190483010561154 no 702 0.22066918216944 226 5280953 A monoamine oxidase inhibitor SGTC_1630 st005209 31.3 µM 0.768512986789953 0.19086583036872 no 703 0.221091239090695 258 3367314 SGTC_203 k066-0004 30.888 µM 0.76842225764579 0.190890269036636 no 704 0.221118180617773 265 6795412 SGTC_2407 paclitaxel 400 µM 0.767934790645763 0.191021605287539 no 705 0.221262963453649 257 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_650 1328-0195 38 µM 0.764732896978443 0.191885655302831 no 706 0.222215306388109 261 2780821 SGTC_2508 celastrol 40.54 µM 0.763614796146883 0.19218794417695 no 707 0.222548414617419 217 122724 Celastrol is a natural product and antioxidant. SGTC_3133 9127736 49.47 µM 0.762416134146592 0.192512336870741 no 708 0.222905839905427 233 27243420 SGTC_3032 9089427 49.47 µM 0.761593774975077 0.192735084580639 no 709 0.223151245646689 231 17173707 SGTC_3314 9135860 59.4275 µM 0.761169435866186 0.19285008444923 no 710 0.223277935678638 246 25252478 SGTC_2188 6126565 140.678 µM 0.758411177542421 0.193598619532168 no 711 0.224102434238336 240 874518 SGTC_1230 0170-0365 3.77 µM 0.755421649393454 0.194411914419617 no 712 0.224998013674491 250 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1702 st027038 51 µM 0.754874057956752 0.194561110591616 no 713 0.22516227634178 242 5521182 SGTC_2683 piperine 63.03 µM 0.752575696398831 0.195188079326193 no 714 0.225852463330096 263 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1867 st057372 64 µM 0.748842090446573 0.196209181243305 no 715 0.226976193659091 228 688837 SGTC_559 1550-0661 158 µM 0.748362984264307 0.196340445823537 no 716 0.227120621618271 242 5830875 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.748286672472631 0.196361358493412 no 717 0.227143630813124 246 3256 An antibiotic and ribosome inhibitor. SGTC_2498 4'-Methoxychalcone 54.63 µM 0.74807481434657 0.196419423688927 no 718 0.227207516228088 244 641818 YHR062C RPP1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.747386775612628 0.196608070253252 no 719 0.227415062834342 269 756377 SGTC_1115 galangin 695.678 nM 0.740303137006583 0.198556638818165 no 720 0.229558038961373 272 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1873 rapamycin 2 nM 0.731424411725613 0.20101538337258 no 721 0.23225997944041 244 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_76 0433-0009 400.328 µM 0.729816132253339 0.201462702639397 no 722 0.232751291095295 259 2841569 SGTC_265 mycophenolic acid 32.932 µM 0.729083936369826 0.201666549598739 no 723 0.232975160050365 266 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2031 5180455 200 µM 0.729038625709798 0.201679168368793 no 724 0.232989017716853 268 29949 SGTC_1788 fluconazole 20 µM 0.728055072109626 0.201953199184534 no 725 0.233289937379647 265 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_351 caspofungin 25 nM 0.727767525966251 0.202033355362444 no 726 0.233377953270989 254 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2298 7976326 193.81 µM 0.727605881325768 0.202078423677537 no 727 0.233427439669066 231 2235818 SGTC_2782 7736369 71.43 µM 0.72757060442961 0.202088260066383 no 728 0.233438240222655 273 2950836 YOL077C BRX1 SGTC_1624 st003710 6.25 µM 0.727435008867368 0.202126071351082 no 729 0.233479757428822 261 24207033 SGTC_643 k048-0106 28.4 µM 0.726141512300519 0.202486980030005 no 730 0.233876011339163 266 6763920 SGTC_999 SEC7.066 22.7 µM 0.725911541358302 0.20255118635151 no 731 0.233946500374436 270 740511 YDR170C SEC7 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.725461016330841 0.202677005141912 no 732 0.23408462616634 261 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1676 st018489 23.4 µM 0.72538682434088 0.202697729326788 no 733 0.234107376907582 260 3696235 SGTC_2717 st081029 62.2815 µM 0.725257978669097 0.202733723034081 no 734 0.234146889938683 271 5292846 SGTC_2211 7117706 200 µM 0.725243310172922 0.202737820996769 no 735 0.234151388552438 253 822771 SGTC_2749 bexarotene 57.39 µM 0.722560234923168 0.203488228537932 no 736 0.234975053090309 267 82146 An retinoic acid receptor inhibitor. SGTC_873 0591-4978 488 µM 0.721408998695627 0.203810715757437 no 737 0.235328955845078 275 3305145 SGTC_327 1273-0057 3.96 µM 0.721144803500551 0.203884765741683 no 738 0.235410213862037 257 3108138 SGTC_1103 duloxetine 36.1 µM 0.720745321261594 0.20399676511979 no 739 0.235533111264152 255 60835 A selective serotonin reuptake inhibitor. SGTC_41 0478-0632 82.643 µM 0.720123126458428 0.204171277482375 no 740 0.235724594824016 279 3750424 SGTC_486 niguldipine 82 µM 0.717132120051067 0.205011431205135 no 741 0.236646289170261 254 1236 A calcium channel blocker. SGTC_401 neomycin 50 µM 0.714078849750411 0.205871190576123 no 742 0.237589211766837 247 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2899 9053889 58.44 µM 0.711447672946242 0.206613807263847 no 743 0.238403432964484 255 6470052 SGTC_1531 st059297 52.4 µM 0.711024062822508 0.206733514009837 no 744 0.23853466233944 267 7566702 SGTC_2845 9003024 42.97 µM 0.709263899708147 0.207231352976594 no 745 0.239080363187405 248 2990173 SGTC_593 1203-0218 61.7 µM 0.708371107036626 0.207484138412214 no 746 0.239357415046856 263 3666956 SGTC_944 3370-0224 231 µM 0.706980962751662 0.207878106671206 no 747 0.239789154187298 244 4580514 SGTC_47 0149-0135 24.25 µM 0.70150337436764 0.209434754392675 no 748 0.241494464761081 264 5239155 SGTC_213 1246-0773 967 nM 0.699708762751312 0.209946243671522 no 749 0.242054601468651 263 6251622 SGTC_2270 7924575 90.91 µM 0.699692554205995 0.209950866675057 no 750 0.24205966371108 267 1262135 SGTC_2047 4141938 200 µM 0.699076763894069 0.210126546779226 no 751 0.242252029461676 281 3807862 SGTC_3323 9138564 53.9225 µM 0.699072638599607 0.210127723984213 no 752 0.242253318435157 270 43912313 YNL103W MET4 SGTC_718 1130-0073 349 µM 0.698877007482644 0.210183554247492 no 753 0.242314448841669 266 6740020 SGTC_3050 9093513 49.47 µM 0.698535374023968 0.210281072336615 no 754 0.242421221800272 284 25236664 SGTC_1255 0566-0045 221 µM 0.697487887033343 0.21058023944503 no 755 0.24274875864687 261 2788469 SGTC_358 0075-0058 9.45 µM 0.69744958091527 0.210591184580479 no 756 0.24276074105726 315 1069125 SGTC_2491 paeonol 100 µM 0.696018960163983 0.211000192155872 no 757 0.243208477974632 274 11092 Increases levels of cortical cytochrome oxidase. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.694955442706807 0.211304548213232 no 758 0.243541612793038 249 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_974 1326-0144 138 µM 0.694312492857347 0.211488671443568 no 759 0.24374312904033 280 5411856 SGTC_1053 3366-3204 134 µM 0.693858741310687 0.211618669987826 no 760 0.243885400060972 286 3632071 YPR165W RHO1 SGTC_1714 st033236 13.627 µM 0.692541791539908 0.211996237193762 no 761 0.244298575248735 280 2916566 SGTC_218 alverine citrate 93.75 µM 0.691941634675107 0.212168431724313 no 762 0.244486991426308 278 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2835 9006588 71.43 µM 0.690813879827693 0.212492223585783 no 763 0.244841255962736 242 2345538 SGTC_225 nsc-122657 1.016 µM 0.68865369775104 0.213113242998264 no 764 0.245520610275511 277 275685 SGTC_1616 st002734 56.1 µM 0.687382048235214 0.213479317366021 no 765 0.24592100357093 262 4026101 SGTC_1720 st037298 9.481 µM 0.686482098346329 0.213738610521542 no 766 0.246204574616965 289 597396 SGTC_3235 9132602 49.47 µM 0.682190871188775 0.214977517053341 no 767 0.247559133141921 275 4912240 SGTC_518 1021-0119 62.6 µM 0.680025223838939 0.215604334296626 no 768 0.248244244833544 286 1097762 SGTC_2447 5741742 33.78 µM 0.677250131278591 0.21640909424739 no 769 0.249123632758544 268 1776504 SGTC_1553 gossypol 38.6 µM 0.67629557700251 0.216686310501344 no 770 0.249426500194015 270 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_822 1487-0950 154 µM 0.675345021069119 0.216962569563066 no 771 0.249728293363813 256 1958375 SGTC_3301 9125354 19.7965 µM 0.674655810681662 0.217163001293399 no 772 0.249947232823454 258 41905162 SGTC_1332 1480-0653 17.5 µM 0.674352812593108 0.217251151087069 no 773 0.250043517571684 274 5749438 SGTC_1012 4112-3522 18 µM 0.673046512848822 0.217631423195335 no 774 0.25045885015586 268 3112398 SGTC_2870 9038528 12.99 µM 0.672736031008401 0.217721862883372 no 775 0.250557620317099 280 6463316 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.672189631244198 0.217881075316613 no 776 0.250731490545483 275 115019 SGTC_757 1066-0008 322 µM 0.671387148404683 0.218115028071235 no 777 0.250986964918347 269 6842497 SGTC_1679 SEC14.276 6.7 µM 0.671126233306919 0.218191125433543 no 778 0.25107005819162 283 1005053 YMR079W SEC14 SGTC_2866 9034245 58.44 µM 0.668890330959476 0.2188438660075 no 779 0.251782719271333 269 6462273 SGTC_2008 4012253 172 µM 0.667149590018112 0.219352828034483 no 780 0.252338293482165 275 603940 SGTC_1951 sophoraflavanone G 9.2 µM 0.666904391730028 0.219424574314537 no 781 0.252416602767644 276 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2644 guaiazulene 100 µM 0.665230288650311 0.219914785629735 no 782 0.252951605244775 268 3515 A coloring agent. SGTC_1418 3966-3099 2.4 µM 0.664994930296191 0.219983753680198 no 783 0.253026867845242 278 740335 SGTC_3153 9100258 49.47 µM 0.66399317878468 0.220277439932439 no 784 0.253347338441103 292 25236848 SGTC_1194 1488-0194 225 µM 0.663579490098546 0.220398787741354 no 785 0.253479743921982 287 1391452 SGTC_2812 7970281 58.44 µM 0.663021696833372 0.220562466569867 no 786 0.253658329161955 294 2233435 SGTC_435 c-PAF 6.7 µM 0.662599525756174 0.220686394720936 no 787 0.253793537000252 272 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_190 3970-0790 3.722 µM 0.661637341979618 0.22096899237313 no 788 0.254101834894061 280 2832352 SGTC_3089 9117425 49.47 µM 0.661619880916952 0.220974122677704 no 789 0.254107431490691 305 9401657 SGTC_3151 9099821 49.47 µM 0.661254430927402 0.221081512643641 no 790 0.254224579872325 293 17174189 SGTC_3061 glucosamine 200 µM 0.660910034155158 0.221182743306433 no 791 0.254335005363479 267 91431 and experimental redox chemotherapeutic SGTC_2551 apiole 73.87 µM 0.656256946242827 0.222553051032861 no 792 0.255829407047734 271 10659 A possible DNA adduct former. SGTC_1514 1189-1591 158 µM 0.655993118423293 0.222630891550696 no 793 0.255914275982942 312 767698 YMR146C TIF34 SGTC_1590 st077108 57.8 µM 0.652776499598451 0.223581179291639 no 794 0.256950188020737 258 5489485 SGTC_2285 7945142 200 µM 0.649037498839829 0.224688688328831 no 795 0.258157069290419 297 2970608 SGTC_1220 1838-0075 193 µM 0.647680327533919 0.225091457014572 no 796 0.258595865316804 276 5529645 SGTC_1845 st056753 3.01 µM 0.645424193032031 0.225761916050397 no 797 0.259326164770958 277 5375839 SGTC_316 k060-0003 58.6 µM 0.644794744373196 0.22594917164276 no 798 0.259530104118847 297 6152314 SGTC_549 1661-1316 519 µM 0.644524368200599 0.226029633195 no 799 0.259617730553201 304 2857282 SGTC_399 oxolinic acid 75 µM 0.642318454544886 0.226686698355966 no 800 0.260333217138467 287 4628 A DNA gyrase inhibitor. SGTC_2878 9043973 25.97 µM 0.642229113167337 0.226713332746749 no 801 0.260362216342859 301 6465167 SGTC_3305 9127027 53.8275 µM 0.642172494344135 0.226730212826005 no 802 0.260380595036252 291 41905295 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.641647254704767 0.226886839192505 no 803 0.260551121744474 293 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1052 3253-3998 198 µM 0.639732981439578 0.227458191389034 no 804 0.261173104766563 270 5450317 SGTC_2988 9073640 71.4286 µM 0.639608090501257 0.227495495665554 no 805 0.261213710656651 304 9102229 SGTC_2556 citropten 84.59 µM 0.6393021030961 0.22758690708012 no 806 0.261313210293616 249 2775 A potential DNA crosslinker. SGTC_2417 cerulenin 830 nM 0.639176829371556 0.227624337620518 no 807 0.261353951868148 293 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2011 4012611 177 µM 0.637842544999058 0.228023223480394 no 808 0.26178809075083 287 2049887 SGTC_65 0798-0905 34.986 µM 0.637797029661068 0.228036837274324 no 809 0.261802906693286 338 3602145 SGTC_1232 0279-0259 161 µM 0.637277611066004 0.228192229532064 no 810 0.261972015890281 294 1560000 SGTC_2108 5365811 200 µM 0.636653948219191 0.22837888672845 no 811 0.262175138272955 271 780283 SGTC_1307 1187-1599 12.2 µM 0.63489857715679 0.22890471528259 no 812 0.262747282558669 297 1538471 SGTC_2934 9036370 36.88 µM 0.633172068978084 0.229422559950969 no 813 0.263310641654841 285 6462800 SGTC_350 k064-0020 19.8 µM 0.632384538532915 0.229658987798305 no 814 0.263567817298786 283 2790705 SGTC_2843 9000894 45.46 µM 0.631341126773939 0.229972444942862 no 815 0.263908750743107 234 2242070 SGTC_1445 4239-0156 97.7 µM 0.630519737121996 0.230219371538627 no 816 0.264177296804021 305 4008346 SGTC_2938 9059746 27.26 µM 0.630349813154618 0.230270472678697 no 817 0.264232869308185 298 6471769 SGTC_2858 9025781 8.96 µM 0.62996529570249 0.230386131813401 no 818 0.264358645159944 278 4894980 YPL153C RAD53 SGTC_1783 st039459 87.517 µM 0.629284252029533 0.230591062855309 no 819 0.264581489658409 329 729761 SGTC_2199 6590217 200 µM 0.627861313092184 0.231019564200934 no 820 0.265047398143183 286 703109 SGTC_927 2425-1185 123 µM 0.62777592038787 0.23104529334012 no 821 0.265075371262549 315 730375 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.623295312610529 0.232397558629808 no 822 0.266545238755199 315 688801 SGTC_1091 telmisartan 47.6 µM 0.622833634143321 0.232537144767914 no 823 0.266696926710148 309 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2765 myclobutanil 7.74 µM 0.620993836424572 0.233093861035288 no 824 0.267301839284472 322 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_776 4476-4378 112 µM 0.620448070577649 0.233259150056283 no 825 0.267481416312266 317 2892008 SGTC_3034 9090421 49.47 µM 0.619635457527242 0.233505376115671 no 826 0.267748908563552 280 17173761 SGTC_3177 9107506 49.47 µM 0.61882483962831 0.2337511411941 no 827 0.268015878286961 292 8897194 SGTC_1609 st001574 46.4 µM 0.618660816347472 0.233800887600737 no 828 0.268069914179186 308 3960012 SGTC_1250 0485-0349 40.2 µM 0.617729614209087 0.234083421865205 no 829 0.26837679367714 308 6842794 YDL195W SEC31 SGTC_39 0986-0283 58.349 µM 0.616632913536768 0.234416412064274 no 830 0.2687384399699 259 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2189 6047310 154.431 µM 0.615071182528701 0.2348910510375 no 831 0.269253856122061 298 711535 SGTC_726 3448-4391 34.2 µM 0.614129681829618 0.235177446944731 no 832 0.269564817801955 309 1356692 SGTC_525 k781-2675 26.7 µM 0.614054894895869 0.235200204710827 no 833 0.269589526367941 296 3651118 YDL195W SEC31 SGTC_3079 9117512 49.47 µM 0.613802810770166 0.235276923211785 no 834 0.269672819825962 347 7185044 SGTC_1032 k061-1018 98.7 µM 0.613752383966418 0.235292271606954 no 835 0.269689483361832 303 4005393 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.613373154609941 0.235407715270869 no 836 0.269814816213468 315 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_546 peri-Naphthalide 147 µM 0.612787035819186 0.235586200965258 no 837 0.270008582038004 280 223824 A penicillin ester. SGTC_1425 4048-4433 7.33 µM 0.612078104759635 0.235802185339341 no 838 0.270243041549183 344 23734946 SGTC_1774 st048371 48.465 µM 0.611735501775796 0.235906602574609 no 839 0.270356384568635 303 4242727 SGTC_1 0258-0098 57.368 µM 0.610491791694924 0.236285869908833 no 840 0.270768039590891 260 6790032 YDR047W HEM12 SGTC_2207 7258803 200 µM 0.610379978097755 0.236319983722464 no 841 0.270805064046455 311 3666799 SGTC_2890 9046729 58.44 µM 0.609990612910688 0.236438798408944 no 842 0.270934012933692 304 903329 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.609926263120708 0.236458437896386 no 843 0.270955327069146 335 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3335 9143315 29.6265 µM 0.6097646502454 0.236507765932951 no 844 0.271008860671731 287 4899691 SGTC_248 streptozotocin 5.23457 mM 0.607291910419463 0.237263209833263 no 845 0.271828602976611 316 5300 DNA alkylating agent. SGTC_335 4077-0256 27.6 µM 0.604227285444412 0.238201316127686 no 846 0.272846271325882 312 3121989 SGTC_1672 st016598 6.51 µM 0.603135251043258 0.238536087051198 no 847 0.273209358718788 323 4665860 YNL267W PIK1 SGTC_1701 st028638 40.4 µM 0.601414471111513 0.239064126647371 no 848 0.273781981283728 297 3490878 SGTC_1902 st060212 70.5 µM 0.600408598067525 0.239373085141411 no 849 0.274116979513497 293 688944 SGTC_1636 st007707 68.9 µM 0.600219884451804 0.239431073675578 no 850 0.274179851674657 335 403051 SGTC_2055 5235184 200 µM 0.599832342147057 0.239550182986517 no 851 0.274308988281373 332 2836034 SGTC_3298 9116858 71.43 µM 0.597663862049045 0.24021725169697 no 852 0.275032121513288 339 2506942 SGTC_2943 9068529 45.32 µM 0.597442956436169 0.240285263538748 no 853 0.275105840614903 326 3270634 SGTC_3158 9100007 49.47 µM 0.594784311802718 0.241104622501354 no 854 0.275993827772006 303 19297233 SGTC_321 4534-3890 65.3 µM 0.594606840983207 0.241159370681566 no 855 0.276053153095186 321 699746 SGTC_1139 k015-0024 46.9 µM 0.593608638652077 0.241467433147474 no 856 0.27638695089806 311 2766652 SGTC_3042 9091578 49.47 µM 0.592649943071754 0.241763504253782 no 857 0.27670772394498 286 25236497 SGTC_2098 5376439 882.5 nM 0.591605561817516 0.242086261500694 no 858 0.277057374306293 317 2844116 SGTC_971 1315-0384 26.7 µM 0.590691380756213 0.242368973131155 no 859 0.277363612079283 331 6769120 SGTC_683 panaxydol 45 µM 0.588490200459397 0.243050424184434 no 860 0.278101654777021 273 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.587587418947842 0.24333021060827 no 861 0.278404628836465 300 5282362 SGTC_478 N-arachidonylglycine 10 µM 0.587076122885529 0.243488746604745 no 862 0.278576291442205 270 5283389 SGTC_1413 3910-0535 34.4 µM 0.586347732911825 0.243714692572636 no 863 0.278820930182284 299 2876951 SGTC_2732 terfenadine 20 µM 0.584977831274266 0.244139941381911 no 864 0.279281311541182 324 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1266 0828-0227 32.9 µM 0.584622434657893 0.244250329954183 no 865 0.279400809615964 312 3913820 SGTC_3208 9114115 49.47 µM 0.584155628014277 0.24439536410013 no 866 0.279557805772346 321 650895 SGTC_2261 9010538 184.68 µM 0.583533394951332 0.244588760478839 no 867 0.27976714142791 340 6457250 SGTC_1689 st020265 53.493 µM 0.58310475292703 0.244722034722665 no 868 0.27991139216557 318 5758320 YPR016C TIF6 SGTC_2582 agaric acid 100 µM 0.582235778473924 0.244992337947062 no 869 0.280203938438889 289 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2219 9098279 200 µM 0.580883067360161 0.245413431750296 no 870 0.280659632572666 291 902349 SGTC_1469 k284-2957 126 µM 0.57948171349724 0.245850077703888 no 871 0.281132090973594 307 23884841 SGTC_2173 5763948 167 µM 0.579453091217426 0.245859000424717 no 872 0.281141744812599 301 2867177 SGTC_1352 1496-0991 99 µM 0.579299343389152 0.245906932807817 no 873 0.281193604245615 332 3000039 SGTC_1295 1013-0063 9.78 µM 0.578395204482202 0.246188908351784 no 874 0.281498665432003 317 6826038 SGTC_2967 9089538 49.85 µM 0.576688062346293 0.246721790473704 no 875 0.28207509905924 315 728216 SGTC_1094 duloxetine 25.4 µM 0.57594039796822 0.246955367238617 no 876 0.282327734269144 287 60834 A selective serotonin reuptake inhibitor. SGTC_2946 9065502 71.43 µM 0.575551731455365 0.247076836720726 no 877 0.282459107370839 282 16489101 SGTC_708 3448-5400 146 µM 0.575152042366595 0.247201784401397 no 878 0.28259423686467 319 3462195 SGTC_2499 avocadenofuran 51.48 µM 0.574947809399952 0.247265643157748 no 879 0.28266329727217 315 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_356 1634-0012 32.5 µM 0.574777631423502 0.247318860470312 no 880 0.282720848340703 333 735457 SGTC_899 1083-0020 478 µM 0.573501609023469 0.247718087619018 no 881 0.283152554982733 336 767123 SGTC_2569 tetrandrine 100 µM 0.572991942156355 0.247877642424589 no 882 0.283325074925014 281 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1096 rimcazole 32.2 µM 0.572735213116005 0.247958034030412 no 883 0.283411995636134 332 18528119 A dopamine reuptake inhibitor. SGTC_919 tnp00227 403.569 nM 0.572709720887737 0.247966017373859 no 884 0.283420627233535 349 1269246 A methoxyflavone. YNL221C POP1 SGTC_355 1311-2252 105 µM 0.570978752168907 0.248508421645452 no 885 0.284007023011843 325 5338538 SGTC_607 4491-0986 66.8 µM 0.569321725688871 0.249028247558376 no 886 0.284568912808953 298 698981 YDR232W HEM1 SGTC_2177 5811945 192 µM 0.568777755319755 0.249199022599686 no 887 0.284753486248703 307 5343475 SGTC_2920 7982904 15.77 µM 0.566809059740901 0.249817598674903 no 888 0.285421957332501 314 6456808 SGTC_1755 st041960 45.185 µM 0.566746475650172 0.249837276335561 no 889 0.285443220025865 333 2257073 SGTC_906 1165-0455 526 µM 0.565839478616094 0.250122546269701 no 890 0.285751453261702 325 3252859 SGTC_3150 9097574 49.47 µM 0.564146286859648 0.25065555323477 no 891 0.286327289635293 322 17217476 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.562558180179802 0.251156026251239 no 892 0.286867887856725 309 16486 A toxic proline analog. SGTC_845 0330-0138 4.51 µM 0.561925003354418 0.251355711701822 no 893 0.28708355870174 331 9039800 SGTC_1981 st071826 47 µM 0.560480541916174 0.251811566519916 no 894 0.287575854107837 301 11838600 SGTC_1282 0886-0010 32.4 µM 0.559419390496162 0.252146731156885 no 895 0.287937765458847 320 2836211 YNL267W PIK1 SGTC_2828 7998861 71.43 µM 0.559137875410973 0.252235687161542 no 896 0.288033813760257 268 2988188 SGTC_1299 1079-1439 3.74 µM 0.558079337179754 0.252570322902946 no 897 0.288395104806353 321 323161 SGTC_2405 ticlatone 3.52 µM 0.557635792422478 0.252710610228869 no 898 0.288546555125512 294 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_756 0508-1999 28.3 µM 0.557389192188594 0.25278862435853 no 899 0.28863077407209 335 6753853 SGTC_1324 1418-0026 34.4 µM 0.556847257110923 0.252960114777722 no 900 0.288815896487582 313 1372513 SGTC_1958 st076513 41.9 µM 0.556688245799066 0.253010444073523 no 901 0.288870224590651 337 732122 YGL099W LSG1 SGTC_2826 7992541 19.48 µM 0.555788683668862 0.253295267207169 no 902 0.28917766121048 364 2985066 SGTC_812 4251-0442 148 µM 0.555379591939315 0.253424851285569 no 903 0.289317524298781 334 5723007 SGTC_2287 7945887 168.79 µM 0.552806101095866 0.254240829687842 no 904 0.290198095153195 325 1245853 SGTC_1062 mesoridazine 14.2 µM 0.551845709556273 0.254545694243772 no 905 0.290527033567373 312 4078 A neuroleptic. SGTC_2167 5876490 200 µM 0.551535592905631 0.254644177872937 no 906 0.290633287168031 327 686534 SGTC_1014 4130-3005 69.3 µM 0.551201299643615 0.254750361605328 no 907 0.290747844626693 318 743608 SGTC_1263 0774-1208 64.8 µM 0.550314129011877 0.255032271713243 no 908 0.291051967481463 346 906585 SGTC_395 anisomycin 6.25 µM 0.549675451460374 0.255235320875449 no 909 0.291270998648095 343 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3049 9092223 49.47 µM 0.547649122656841 0.255880092911165 no 910 0.291966426421973 324 8623917 SGTC_471 1-acyl-paf 4 µM 0.54744438291198 0.25594528776389 no 911 0.29203673525072 304 16759367 SGTC_2155 5570423 76 µM 0.54609794265827 0.256374247767762 no 912 0.292499306964305 341 797402 SGTC_332 4112-0506 40.9 µM 0.546027111705767 0.256396824043531 no 913 0.292523650477422 335 2790355 SGTC_1931 st074438 57.1 µM 0.543437764037352 0.257222849388974 no 914 0.293414215228616 331 2787313 SGTC_3090 9117696 49.47 µM 0.542373870005614 0.257562641762882 no 915 0.293780488296074 318 7923821 SGTC_3086 9117350 49.47 µM 0.541828649898295 0.257736867486946 no 916 0.293968276386744 308 2679265 SGTC_1520 flindersine 88 µM 0.539915288686873 0.258348768008145 no 917 0.294627726869457 339 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2624 nerol 100 µM 0.537413597867574 0.259149952731253 no 918 0.295490976320573 347 637566 A natural product oil. SGTC_52 0329-0193 875 nM 0.535565321189933 0.259742700782505 no 919 0.296129500697814 358 3739292 SGTC_745 0469-0705 296 µM 0.534305977553298 0.26014697659396 no 920 0.296564928624069 357 3486736 SGTC_1234 0326-0494 15.5 µM 0.533001883043958 0.260565959954359 no 921 0.297016138403311 358 1547813 SGTC_2319 6033012 152.6 µM 0.532662959725865 0.260674907094115 no 922 0.297133455459331 314 847246 SGTC_637 1181-0519 7.26 µM 0.532603176939877 0.260694126744958 no 923 0.297154151248002 322 6252091 YGR060W ERG25 SGTC_224 benfluorex 43.875 µM 0.531672338136848 0.260993477454003 no 924 0.297476476863484 346 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_853 0419-0306 21 µM 0.531105189369903 0.261175954813886 no 925 0.297672944180712 335 762713 SGTC_1274 0865-0114 173 µM 0.53091650284203 0.261236678319109 no 926 0.297738320641167 305 870624 SGTC_2944 9067346 25.62 µM 0.529707071721574 0.261626072242425 no 927 0.298157522055454 329 6473075 SGTC_1938 st074717 56.4 µM 0.529621960147038 0.261653486365547 no 928 0.298187032736116 313 17250979 SGTC_3328 9140624 29.0385 µM 0.527500344729594 0.262337326888995 no 929 0.298923088551938 326 4904392 SGTC_2395 5646831 180.19 µM 0.527499844031768 0.262337488382225 no 930 0.298923262357301 347 6808628 SGTC_2691 st077356 60.2 µM 0.523934934602895 0.263488590370181 no 931 0.300161897825468 357 2839272 SGTC_209 4077-0173 175.592 µM 0.523441086728497 0.263648255899047 no 932 0.300333669207142 299 15993494 SGTC_2553 4-methylesculetin 85.09 µM 0.523408930675072 0.263658653956159 no 933 0.300344855344959 326 5319502 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.519916597101769 0.264789186930561 no 934 0.301560853462791 320 88881 An O-methylated flavonoid and antioxidant. SGTC_2477 5967686 25.23 µM 0.519014958569638 0.265081463772027 no 935 0.301875154987276 338 776118 SGTC_402 epigallocatechin gallate 10 µM 0.518605790522667 0.265214154493451 no 936 0.302017835121864 335 65064 An antioxidant. SGTC_1369 1866-0067 208 µM 0.515803859019202 0.266123709241876 no 937 0.302995703514194 336 3531355 SGTC_991 3996-0057 64.7 µM 0.511840384379213 0.267413012597383 no 938 0.304381362008178 310 715343 SGTC_2904 7225135 42.03 µM 0.511209790804193 0.267618432441161 no 939 0.30460208181514 362 4446116 SGTC_1412 3909-8563 178 µM 0.511117978939499 0.267648347368834 no 940 0.304634223659448 353 23767530 SGTC_2625 euphol 100 µM 0.509940924030156 0.268032014729326 no 941 0.305046425041706 335 6708538 A triterpene alcohol. SGTC_2796 7949634 45.45 µM 0.50976422709844 0.268089633935164 no 942 0.305108325195004 336 2971588 SGTC_2894 9048625 32.47 µM 0.50788025220762 0.268704367781843 no 943 0.305768662286199 363 4092861 SGTC_795 0685-0265 78 µM 0.507201819257791 0.268925911178174 no 944 0.306006609332478 339 302754 SGTC_2760 etidronate 98.04 µM 0.506578482178394 0.26912954373453 no 945 0.306225304771652 330 3305 A chelator and antioxidant. SGTC_2147 5545932 89.7195 µM 0.504343256887926 0.269860385549054 no 946 0.307010092498506 362 797404 SGTC_1056 3448-1962 115 µM 0.501965664440146 0.270638865517727 no 947 0.307845836847231 344 715507 SGTC_2622 2-methoxyxanthone 59.94 µM 0.50155293820955 0.270774115998166 no 948 0.307991015454183 326 71034 A hepatoprotective. SGTC_2891 9063876 19.48 µM 0.501509205787878 0.27078844909963 no 949 0.308006400323282 336 6472478 SGTC_3122 9126309 49.47 µM 0.498455113426998 0.271790349736475 no 950 0.309081649626082 361 17591206 SGTC_1572 epiandrosterone 68.9 µM 0.497792572521947 0.272007940755261 no 951 0.309315125808871 344 441302 A steroid. SGTC_3252 9135871 49.47 µM 0.497779312192335 0.27201229658352 no 952 0.309319799470721 354 17682838 SGTC_1905 st060207 84.5 µM 0.497239663894781 0.272189592741565 no 953 0.309510027068604 326 1948547 SGTC_3239 9133757 49.47 µM 0.497026371866008 0.272259683580297 no 954 0.30958522720919 365 17036923 SGTC_339 3091-4833 71.4 µM 0.495876328504947 0.272637758906497 no 955 0.309990834074984 327 3240077 SGTC_752 1896-0090 130 µM 0.495621956905421 0.27272141843255 no 956 0.310080579230347 342 772567 SGTC_3128 9127691 49.47 µM 0.49503373730267 0.272914925017238 no 957 0.310288153036784 364 41316314 SGTC_253 dyclonine 31.25 µM 0.494393955274801 0.273125471363751 no 958 0.310513991074695 327 3180 An oral anasthetic. SGTC_562 3772-2733 112 µM 0.49396795101494 0.273265710054674 no 959 0.310664406865754 354 2876874 YIL048W NEO1 SGTC_2449 5812982 45.77 µM 0.493751194050492 0.273337079163852 no 960 0.310740952690135 344 776185 SGTC_474 dl-dihydrosphingosine 5 µM 0.491930012476909 0.273937083333342 no 961 0.31138441034324 308 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1243 0416-0003 5.65 µM 0.491926226025838 0.273938331490588 no 962 0.311385748768865 357 2141977 SGTC_2642 cholecalciferol 100 µM 0.49153948157957 0.2740658318683 no 963 0.311522467395226 340 9821465 A vitamin D precursor, similar to steriods. SGTC_2794 7785382 27.27 µM 0.49097687646611 0.274251361632194 no 964 0.311721401202486 372 2205081 SGTC_1627 st003713 25.6 µM 0.489440453631809 0.274758342101671 no 965 0.31226495097656 342 16195070 YER133W GLC7 SGTC_2310 7668677 200 µM 0.486875795203946 0.275605642230096 no 966 0.313173176446817 378 2197143 SGTC_1456 k015-0012 13 µM 0.482429562931726 0.277077605738124 no 967 0.314750412188188 364 2989616 SGTC_326 k292-0812 17.5 µM 0.481249834861936 0.277468809744449 no 968 0.315169472946002 361 3579357 SGTC_26 0302-0163 425.158 µM 0.48074657210011 0.277635776422882 no 969 0.31534831342788 367 3100915 SGTC_1565 sinapyl alcohol 95.1 µM 0.480385894862279 0.27775546791683 no 970 0.315476511049296 357 5280507 A phenol propionate derived from cinnamic acid. SGTC_2370 9071495 200 µM 0.480005253592648 0.277881811839166 no 971 0.3156118286955 360 21791103 SGTC_973 1325-0077 65.9 µM 0.479837697272905 0.277937436671983 no 972 0.315671402662695 361 2835149 SGTC_1611 st001856 99.4 µM 0.478797638166093 0.278282833807459 no 973 0.316041298536091 387 647478 SGTC_2767 sibutramine 71.45 µM 0.477890136989395 0.278584380129563 no 974 0.316364200857089 361 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_186 3455-3465 67.277 µM 0.476834828486142 0.278935240176986 no 975 0.316739871340151 359 755278 SGTC_666 0272-0154 136 µM 0.476778911930242 0.278953836835949 no 976 0.31675978188687 343 6870312 SGTC_587 k089-0003 57 µM 0.474815648776708 0.279607158522162 no 977 0.317459189044592 351 9659696 SGTC_1367 1812-0510 76.9 µM 0.468229835582894 0.281804150640251 no 978 0.319810119134078 331 1142582 YDR527W RBA50 SGTC_99 0109-0120 622.8 µM 0.468110715602227 0.281843964909105 no 979 0.319852708346383 366 759414 SGTC_1239 0337-0584 35.4 µM 0.468005303728595 0.281879199686081 no 980 0.319890398451605 368 914301 YML130C ERO1 SGTC_3285 9112818 20.8695 µM 0.467614964930192 0.282009692085078 no 981 0.320029980609978 350 17017947 YPR165W RHO1 SGTC_687 k029-0044 34.9 µM 0.466596958961446 0.282350153878487 no 982 0.320394131568724 363 5829338 SGTC_2932 9016711 44.54 µM 0.466410630410043 0.282412490978689 no 983 0.320460801903052 353 7117328 SGTC_2594 a-mangostin 100 µM 0.466305747299151 0.282447583032202 no 984 0.320498332742743 380 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1686 st019653 115.5 µM 0.464289507750186 0.283122588819133 no 985 0.321220170094555 366 97252 SGTC_2595 hexamethylquercetagetin 100 µM 0.463943932562671 0.283238359702542 no 986 0.321343957984616 387 386331 SGTC_515 4092-1064 102 µM 0.46159790243261 0.28402490123641 no 987 0.32218484953445 378 717353 SGTC_1501 4491-0275 38.4 µM 0.459547560050632 0.2847131636115 no 988 0.322920503448154 372 5104718 SGTC_2647 atorvastatin 60.16 µM 0.458211297754003 0.285162150445597 no 989 0.323400321948237 356 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1302 1159-0335 255 µM 0.456292887256201 0.285807329629697 no 990 0.324089689002461 355 649284 SGTC_3164 9100705 49.47 µM 0.455513222279173 0.28606973641908 no 991 0.324370028668186 363 17174235 SGTC_1108 betulinic acid 729.144 nM 0.455376807686587 0.286115660358667 no 992 0.324419088720679 329 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1987 st072290 61.9 µM 0.454732848356533 0.286332496388923 no 993 0.324650722960907 367 54697379 SGTC_2111 5486399 200 µM 0.454060582194196 0.28655894718393 no 994 0.324892611636339 356 689674 SGTC_2736 butenafine 14.65 µM 0.453348390027985 0.28679893956445 no 995 0.325148946676903 360 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1343 1487-0095 224 µM 0.45290229773376 0.286949310916041 no 996 0.325309548160596 387 4560101 YGL055W OLE1 SGTC_3192 9110362 49.47 µM 0.452467373608623 0.287095953586621 no 997 0.32546616013902 362 16649480 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.45226366034173 0.287164651463077 no 998 0.325539525920579 352 390807 SGTC_905 2-aminofluorene 215 µM 0.451982520105765 0.287259472682337 no 999 0.325640787536549 340 1539 An established DNA mutagen. YPR165W RHO1 SGTC_477 mead ethanolamide 10 µM 0.451362645652276 0.28746859239309 no 1000 0.325864100532386 334 16061185 SGTC_440 fluspirilene 35.1 µM 0.449639186368399 0.28805039349384 no 1001 0.326485313888825 361 3396 An atypical antipsychotic. SGTC_1693 xanthone 101.9 µM 0.449420378087876 0.288124297988196 no 1002 0.326564216858661 381 7020 An insecticide. SGTC_1187 1391-0724 117 µM 0.448812003369073 0.288329829111124 no 1003 0.326783639509852 357 6997986 SGTC_3266 9136860 49.47 µM 0.446516846826122 0.289105838228376 no 1004 0.32761197305299 370 4871271 YPR165W RHO1 SGTC_760 0568-0725 82.9 µM 0.443229702324011 0.290218953241948 no 1005 0.328799798459449 370 3916171 SGTC_2764 methyldopa 94.69 µM 0.442398991778108 0.290500571522555 no 1006 0.329100254238326 375 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_977 1348-1378 135 µM 0.442021070861672 0.29062873239603 no 1007 0.329236979232149 355 X977 SGTC_2458 5808907 16.39 µM 0.441548431756181 0.290789051400027 no 1008 0.329408003708502 397 2731747 SGTC_484 loperamide 105 µM 0.439438607624193 0.29150520670355 no 1009 0.330171878522787 343 3955 An opioid-receptor agonist. SGTC_1277 0873-0036 22 µM 0.438296060354277 0.291893374147075 no 1010 0.330585840716647 354 5965735 SGTC_884 0851-0618 334 µM 0.437759799619828 0.292075645610551 no 1011 0.33078020763628 381 9642473 SGTC_2133 5320837 200 µM 0.437713688042288 0.292091321102908 no 1012 0.330796922841484 373 2841355 SGTC_219 mitoxanthrone 164.414 µM 0.437481072381129 0.292170404068014 no 1013 0.330881249942815 359 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1654 st012436 41.8 µM 0.436957909593779 0.292348301503775 no 1014 0.331070936628524 365 4323132 SGTC_1154 4088-0362 150 µM 0.434013849741981 0.293350344174937 no 1015 0.332139191898917 357 6618304 SGTC_1928 4'-methoxychalcone 40.3 µM 0.43326293673599 0.293606180063955 no 1016 0.332411880401395 397 641818 SGTC_398 bronopol 33.3 µM 0.433053351479401 0.293677604147627 no 1017 0.332488005581023 366 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2171 5739187 198.077 µM 0.431580846868726 0.294179642236389 no 1018 0.333023040708152 333 2262761 SGTC_1668 st014914 51.6 µM 0.431039707079518 0.29436423889336 no 1019 0.333219749577522 369 2839556 SGTC_400 oxethazaine 37.5 µM 0.430311588467577 0.29461270318374 no 1020 0.333484499225655 373 4621 A local anesthetic. SGTC_454 lyso-paf C-16 6.67 µM 0.428061919287439 0.295380994268815 no 1021 0.33430302027483 383 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_113 0099-0221 2.5 µM 0.424028930807591 0.296760614334864 no 1022 0.335772357187805 384 89219 SGTC_696 1560-0013 611 µM 0.421958673312778 0.297469959848315 no 1023 0.336527591247486 342 1650269 SGTC_669 0108-0021 26.2 µM 0.420971884136131 0.297808341968888 no 1024 0.336887806349751 388 17201 SGTC_1452 4194-0072 190 µM 0.419638588068571 0.298265824190966 no 1025 0.337374747152993 367 1343545 SGTC_1137 ixabepilone 100 µM 0.418728303157224 0.29857834598854 no 1026 0.337707354181218 350 154225 A novel microtubule stabilizer. SGTC_291 SEC14.278 35.5 µM 0.416947150391046 0.29919028720522 no 1027 0.338358532311136 363 1068044 SGTC_1617 st002906 78 µM 0.415759233696214 0.299598729558961 no 1028 0.338793096125836 386 5150859 SGTC_740 k014-0057 261 µM 0.414356783861457 0.300081259967589 no 1029 0.3393064167724 403 4012779 SGTC_883 0850-0245 24.6 µM 0.41423078754424 0.300124627781114 no 1030 0.33935254820136 376 6823229 YPR165W RHO1 SGTC_255 tunicamycin 200.472 nM 0.412091664768508 0.300861343971754 no 1031 0.340136118918232 347 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_376 3970-0862 59.1 µM 0.411264404025763 0.301146472018671 no 1032 0.34043933387247 384 3135186 SGTC_2156 5649887 115 µM 0.410448885133558 0.301427672167641 no 1033 0.340738346092065 369 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1939 st074455 53.6 µM 0.410240460313295 0.301499558363751 no 1034 0.340814781687156 393 1644229 SGTC_2293 7624732 200 µM 0.410223876283103 0.301505278564925 no 1035 0.340820863826176 362 894453 SGTC_580 1123-0028 41 µM 0.408574110567558 0.302074563358614 no 1036 0.341426116595143 375 1677248 YPR107C YTH1 SGTC_2605 digitonin 300 nM 0.406811642355103 0.302683271067698 no 1037 0.342073167595412 363 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3163 9099914 49.47 µM 0.406567526220954 0.302767625330799 no 1038 0.342162826034328 395 16268368 SGTC_1799 st045822 46.1415 µM 0.403643984718741 0.303778671233413 no 1039 0.343237268141889 397 3674992 SGTC_1885 st057546 99.9 µM 0.403630895024816 0.303783201417148 no 1040 0.343242081644789 365 702008 SGTC_1351 1496-0003 46.5 µM 0.40198299639541 0.304353759647835 no 1041 0.343848270058551 360 3891978 SGTC_2439 5492030 7.2 µM 0.400907134794103 0.304726516540025 no 1042 0.344244248379676 376 5722370 SGTC_1692 fluoroquinolonic acid 71 µM 0.400371280601846 0.304912251189295 no 1043 0.344441536986136 380 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_121 0557-0495 61.343 µM 0.396387452897623 0.306294676103645 no 1044 0.345909610405875 413 3104427 SGTC_451 chloral hydrate 100 µM 0.396020012185641 0.306422320837863 no 1045 0.346045132507807 384 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_18 0111-0177 500 nM 0.395852491920904 0.30648052327483 no 1046 0.34610692507192 374 721752 SGTC_960 1222-0186 7.7 µM 0.394687671474774 0.306885357827462 no 1047 0.346536701195805 385 3126296 SGTC_1431 4049-0260 9.09 µM 0.393644450015656 0.307248130559898 no 1048 0.34692177951813 370 3854841 SGTC_732 3970-1727 52.7 µM 0.393441372162382 0.307318771370542 no 1049 0.346996758877937 399 1275699 SGTC_2150 5556613 200 µM 0.392831680325086 0.307530896157702 no 1050 0.347221902143256 385 743190 SGTC_2997 9067075 71.4286 µM 0.392480199017705 0.307653213256924 no 1051 0.347351719517494 412 27209819 SGTC_1417 3966-0327 90.4 µM 0.390711254710171 0.308269138380685 no 1052 0.348005339398622 384 651118 SGTC_2421 5690543 90.72 µM 0.390416429227527 0.308371845631156 no 1053 0.348114320556461 394 3397993 SGTC_1893 st059353 36.1 µM 0.389817125319548 0.308580669123918 no 1054 0.348335889706932 406 3112488 SGTC_590 k048-0076 22.4 µM 0.389186009091268 0.308800644357087 no 1055 0.348569276179453 391 6832814 SGTC_214 4373-3496 70 µM 0.387420683484889 0.309416311859553 no 1056 0.349222396939961 382 3779166 SGTC_2220 6782180 200 µM 0.387038050834652 0.309549827859833 no 1057 0.349364019226738 389 833803 SGTC_2092 5303694 80.6725 µM 0.386856578619076 0.309613159642206 no 1058 0.349431194143353 382 1963699 SGTC_1914 st062367 72.6 µM 0.382929173416958 0.310985162842051 no 1059 0.350886139886822 377 978205 SGTC_1013 4112-3890 241 µM 0.379106134977764 0.312323234829842 no 1060 0.352304525353148 363 705171 SGTC_1716 st033144 30.6155 µM 0.378622253651998 0.312492771463135 no 1061 0.352484197197754 415 674617 SGTC_1350 1495-0454 146 µM 0.377968180467488 0.312722000999242 no 1062 0.352727115957161 401 1069057 SGTC_1446 4239-0190 62 µM 0.377855590170244 0.31276146723101 no 1063 0.352768937363076 391 1340085 SGTC_2864 9034755 47.6 µM 0.377428346327558 0.312911248368132 no 1064 0.352927652283965 361 4930451 SGTC_2914 7968218 45.32 µM 0.376743883365512 0.313151268547297 no 1065 0.353181973733136 384 2977111 SGTC_325 2810-4341 181 µM 0.37534388582557 0.313642451327202 no 1066 0.353702365878739 375 774970 SGTC_940 3232-1287 54.8 µM 0.374908680542165 0.313795208517028 no 1067 0.353864191514237 400 1585493 YIL048W NEO1 SGTC_2743 auranofin 4.32 µM 0.373537596237891 0.314276668156129 no 1068 0.354374184559832 355 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3230 9131665 49.47 µM 0.373408661284567 0.314321960259004 no 1069 0.354422157083174 401 15943720 SGTC_1512 0259-0544 12.2 µM 0.373348965781437 0.314342930964605 no 1070 0.354444368630214 380 18476 SGTC_3104 9120930 49.47 µM 0.373185729612142 0.314400278002455 no 1071 0.354505108192484 399 17014836 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.371381448214117 0.315034444185767 no 1072 0.35517672065986 397 165506 SGTC_2734 clemastine 41.6 µM 0.369407523639509 0.315728861323174 no 1073 0.355911995454031 424 26987 Clemastine is a selective histamine H1 antagonist. SGTC_634 1611-4317 11.2 µM 0.365495204228029 0.317107118542985 no 1074 0.357370893022941 409 2843522 SGTC_929 2805-0021 398 µM 0.363562652266435 0.317788869338742 no 1075 0.358092310020769 401 3098024 SGTC_935 2996-0153 430 µM 0.362625447045184 0.318119712118685 no 1076 0.3584423491928 390 23738523 SGTC_31 0508-1974 57.237 µM 0.360200514583132 0.3189764107089 no 1077 0.359348594959309 374 6810525 SGTC_1437 4092-1038 11.6 µM 0.35779495290551 0.319827222419764 no 1078 0.360248383941319 395 3977136 SGTC_2818 7996756 12.99 µM 0.357631349852265 0.319885120915582 no 1079 0.360309607080139 404 2241621 SGTC_3018 9082602 49.47 µM 0.357493438814817 0.319933930513795 no 1080 0.360361218597605 389 17332089 SGTC_2903 5923464 63.88 µM 0.356570684990559 0.320260592553077 no 1081 0.36070661335096 394 2876576 SGTC_844 0330-0132 15.3 µM 0.356005964835763 0.320460576636509 no 1082 0.360918049081366 407 2828079 SGTC_1183 1254-0324 198 µM 0.353551785526793 0.321330279072234 no 1083 0.361837406449368 367 5799357 SGTC_1719 st032227 49.2 µM 0.352488900294569 0.321707244771808 no 1084 0.362235820642707 370 3125804 SGTC_3116 9124943 49.47 µM 0.351182096387423 0.322170970965861 no 1085 0.362725870416484 353 41905195 YPL160W CDC60 SGTC_450 aminopyrene 156 nM 0.350424706014954 0.322439861720921 no 1086 0.363009993840905 420 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2081 5214970 32.255 µM 0.350150173562518 0.32253734991719 no 1087 0.3631129991258 390 2063512 SGTC_1591 genipin 88.4 µM 0.349236506691621 0.322861886609269 no 1088 0.363455880572633 390 442424 A DNA cross-linking agent. SGTC_252 miconazole 1.30953 nM 0.347847744253737 0.323355436784593 no 1089 0.363977265653073 403 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2708 st078559 56 µM 0.347816875918889 0.3233664105717 no 1090 0.363988857461807 384 17250902 SGTC_2369 9071472 200 µM 0.346053852981226 0.323993425366324 no 1091 0.364651121597067 378 17296037 SGTC_2231 micatex 6.853 µM 0.345616807847447 0.324148936755971 no 1092 0.364815356361165 408 20737 An antifungal of unknown mechanism. SGTC_724 3910-0327 137 µM 0.344978214429556 0.324376219146394 no 1093 0.365055374437692 413 2885483 SGTC_469 w7 172 µM 0.3441253293671 0.324679872340621 no 1094 0.365376017411069 403 45115570 A P450 inhibitor. SGTC_576 1073-0113 22.7 µM 0.343328660412466 0.324963616178508 no 1095 0.365675610908771 417 5439563 SGTC_1548 st061468 90.8 µM 0.342738378382636 0.325173918188325 no 1096 0.365897643881271 413 390799 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.341062016491108 0.325771465505589 no 1097 0.366528447552074 361 688803 SGTC_762 1165-0429 115 µM 0.339604566410462 0.326291344712286 no 1098 0.367077169411342 422 5967793 SGTC_1924 st058459 75.1 µM 0.337999705167776 0.326864196824905 no 1099 0.367681704979238 403 688683 SGTC_1333 1482-0047 286 µM 0.335157752786901 0.327879627316595 no 1100 0.368753044572797 420 3811116 SGTC_994 3910-0338 138 µM 0.334120281125996 0.328250634066635 no 1101 0.369144398262394 405 3479481 SGTC_921 1561-0023 372 µM 0.333599372947731 0.328436978217595 no 1102 0.369340945746121 382 24050882 SGTC_803 4488-1585 147 µM 0.332878390998126 0.328694965050084 no 1103 0.369613040801367 425 747204 SGTC_1217 1183-1422 255 µM 0.332020977394687 0.3290018771188 no 1104 0.369936709501839 397 2849664 SGTC_410 α-linolenic acid 100 µM 0.330717876446471 0.329468544185391 no 1105 0.370428798998176 424 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1603 st002045 67.8 µM 0.330482361581715 0.329552915242426 no 1106 0.370517759037882 416 5887985 SGTC_2851 9015922 71.43 µM 0.329667645760189 0.329844846673123 no 1107 0.370825551599651 437 2996893 SGTC_2850 9015429 58.44 µM 0.329439032642366 0.329926782650313 no 1108 0.370911934513181 415 6457570 SGTC_1738 st035555 74 µM 0.329028821764632 0.330073824543334 no 1109 0.371066951597854 429 5331140 SGTC_40 0327-0103 19.753 µM 0.328627924859144 0.330217553169032 no 1110 0.37121846918606 394 409036 SGTC_306 1672-3436 11.6 µM 0.326735842636713 0.330896235982937 no 1111 0.371933844151051 422 6797378 SGTC_3006 9075424 71.4286 µM 0.32673297831191 0.330897263827669 no 1112 0.371934927455918 416 7465181 SGTC_1960 st011366 51.8 µM 0.32673265720319 0.33089737905557 no 1113 0.37193504890123 402 3972846 SGTC_1923 st058458 19.1 µM 0.326514607347804 0.330975628611413 no 1114 0.372017519652261 427 3534982 SGTC_1023 4482-3888 16 µM 0.326308931033379 0.331049444555498 no 1115 0.372095315867875 415 3303168 SGTC_46 0329-0187a 2.197 µM 0.324832843530708 0.331579395685515 no 1116 0.372653792887668 409 46494817 SGTC_808 0711-0032 135 µM 0.324234999373186 0.33179413224113 no 1117 0.372880063217516 420 4252555 SGTC_245 methotrexate 289.6 µM 0.323004888248088 0.332236143317968 no 1118 0.373345770024348 411 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3330 9141424 71.43 µM 0.321497418203279 0.332778135048431 no 1119 0.373916734239208 384 27261020 SGTC_1273 0849-0096 14.1 µM 0.321378616620756 0.332820863527782 no 1120 0.373961742902755 419 5286025 SGTC_3021 9087658 49.47 µM 0.318386444562218 0.333897750486265 no 1121 0.375095909697596 420 25237042 SGTC_772 k072-0172 35.3 µM 0.318235650317047 0.333952057865412 no 1122 0.375153096137023 364 5861980 SGTC_1148 3909-7663 27.7 µM 0.315780266926514 0.334836833804038 no 1123 0.376084648510348 406 4084526 SGTC_1838 st055369 84.5 µM 0.314577031887408 0.335270744370128 no 1124 0.376541410158103 369 676036 SGTC_3209 9113616 49.47 µM 0.314095658309805 0.335444398899369 no 1125 0.376724193481548 433 16649353 SGTC_226 1,3-diallylurea 8.28947 mM 0.31215289847342 0.336145602505903 no 1126 0.377462163173021 398 74537 YKL182W FAS1 SGTC_3342 9147791 14.508 µM 0.310763425940145 0.336647457295908 no 1127 0.377990237889615 415 1838168 SGTC_1859 st055998 20 µM 0.310412575279635 0.336774224887589 no 1128 0.378123616219201 404 676301 SGTC_1920 st075728 45.7 µM 0.309965133857578 0.336935919074102 no 1129 0.37829373527586 436 3400306 SGTC_1399 3562-5772 25 µM 0.309758029160084 0.337010771759287 no 1130 0.378372485318229 389 23847490 SGTC_1129 3453-1384 223 µM 0.309279714686092 0.337183670930924 no 1131 0.378554380192026 427 1084452 SGTC_652 0437-0092 114 µM 0.307865977376733 0.337694903899532 no 1132 0.379092157657478 395 3091274 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.307215315848092 0.337930295616485 no 1133 0.379339744254528 411 17037758 SGTC_2823 7987624 58.44 µM 0.30497037530562 0.338742940483717 no 1134 0.380194357632213 416 2239440 SGTC_1201 1889-3372 45.9 µM 0.303754364482651 0.339183437537304 no 1135 0.380657518364469 404 5392199 SGTC_419 nsc-638432 893 µM 0.301614616546667 0.339959089819093 no 1136 0.381472932117832 389 368090 SGTC_11 0438-0307 1.3 µM 0.300235567218893 0.340459350617704 no 1137 0.381998738519387 422 4011476 SGTC_2324 6149169 200 µM 0.300091526895973 0.340511618571579 no 1138 0.382053671047423 440 2888231 SGTC_2863 9028737 58.44 µM 0.298584718080093 0.341058578194517 no 1139 0.382628463515988 441 6460917 SGTC_2505 galangin 7.89 µM 0.297868681609248 0.341318610949345 no 1140 0.382901695985 449 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.297461203371875 0.341466622663722 no 1141 0.383057211698434 434 1241132 A phosphatase inhibitor. SGTC_2917 7979103 53.79 µM 0.296272639932398 0.341898493693339 no 1142 0.383510939331878 410 2980565 SGTC_1841 st054148 70 µM 0.294918644490774 0.342390727515967 no 1143 0.384028014414825 425 675442 SGTC_1460 k062-0059 9.15 µM 0.294561158922105 0.34252073316043 no 1144 0.384164568484505 382 1373085 SGTC_155 k072-0202 43.6 µM 0.293737558936499 0.342820320149398 no 1145 0.384479225899635 434 5857737 SGTC_1875 nocodazole 6 µM 0.292056894997551 0.343431973309509 no 1146 0.38512156166276 416 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_620 0109-0052 432 µM 0.292028249914118 0.343442401830606 no 1147 0.385132512313198 421 493037 SGTC_299 1273-0059 1.44 µM 0.291778819609177 0.343533214394537 no 1148 0.385227870211635 403 2848077 SGTC_898 1000-0849 28.3 µM 0.29081076977799 0.343885747402764 no 1149 0.385598024038234 439 6751807 SGTC_2198 6589944 200 µM 0.290757577560957 0.343905122256866 no 1150 0.385618366203492 395 5290268 SGTC_1450 4112-4260 37.6 µM 0.289391388197264 0.344402886513838 no 1151 0.386140942214936 438 1633175 SGTC_188 3229-0966 278.469 µM 0.288876327175327 0.344590616449452 no 1152 0.386338009978225 424 5722370 SGTC_1657 st012939 43.4 µM 0.288597302093269 0.344692331768898 no 1153 0.386444780157513 430 24207257 SGTC_1001 4048-4355 44.4 µM 0.288226752206161 0.344827428738275 no 1154 0.38658658599731 428 21824233 SGTC_3109 9122853 49.47 µM 0.28668208413829 0.34539080470342 no 1155 0.387177878413907 451 1234709 SGTC_1507 4075-3230 155 µM 0.286036783905351 0.345626262102312 no 1156 0.387424974253042 433 659771 SGTC_3234 9132280 49.47 µM 0.284889264846966 0.346045116812638 no 1157 0.387864490374436 402 17612295 SGTC_1516 st013856 110 µM 0.28423757188052 0.346283074497742 no 1158 0.388114162066145 430 5281404 A mutagen and neurotoxin. SGTC_3005 9076496 71.4286 µM 0.281569458004757 0.347257935550023 no 1159 0.389136830991792 432 21368410 SGTC_969 1313-0238 134 µM 0.280852467849036 0.347520078234084 no 1160 0.389411779477363 425 5212874 SGTC_2815 7968870 71.43 µM 0.280163213384011 0.347772149085338 no 1161 0.389676144194012 423 2977326 YHR190W ERG9 SGTC_1254 0550-0035 264 µM 0.279973698243104 0.3478414694594 no 1162 0.389748842000794 437 15121435 SGTC_874 0599-0792 117 µM 0.274985115068782 0.349668003784448 no 1163 0.39166383704664 443 765305 SGTC_1967 st070177 51.4 µM 0.274898235928046 0.349699844964248 no 1164 0.391697211240751 449 5729214 SGTC_174 3553-0389 74.3 µM 0.274651708294264 0.349790203026308 no 1165 0.391791917956489 399 738071 SGTC_2545 solidagenone 89.61 µM 0.274608649423053 0.34980598596841 no 1166 0.391808460225714 423 6708572 An anti ulcer agent SGTC_2317 5986382 200 µM 0.273905926503359 0.350063601032929 no 1167 0.392078458506643 441 877883 SGTC_2652 actinonin 100 µM 0.273353679371655 0.350266100789878 no 1168 0.392290677869244 435 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1118 chelidonine 707.474 nM 0.270376858222692 0.351358383149568 no 1169 0.3934351708934 439 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_876 0720-0963 56.8 µM 0.270366240323135 0.351362281370554 no 1170 0.393439254792909 439 765861 SGTC_103 0844-0104 51.839 µM 0.270157328912864 0.351438983603589 no 1171 0.393519609529249 405 5375804 SGTC_3202 9113761 49.47 µM 0.268830331683121 0.351926334382723 no 1172 0.394030125480369 445 4798415 SGTC_2266 7929956 200 µM 0.266640461770812 0.352731114223912 no 1173 0.394872999564327 414 2967153 SGTC_1268 0828-0275 2.46 µM 0.265994608256732 0.352968592265781 no 1174 0.395121680739641 417 745337 SGTC_386 1509-0011 3.07 µM 0.265950601219313 0.352984775582716 no 1175 0.395138626883652 425 3107280 SGTC_2846 9008642 19.48 µM 0.265208070138442 0.353257876894074 no 1176 0.395424589183447 448 2992898 SGTC_2344 7990960 76.95 µM 0.264927105029801 0.353361234967027 no 1177 0.3955328086804 429 140813 SGTC_1831 st055328 12 µM 0.264053616186697 0.353682632611564 no 1178 0.395869302310372 433 1103068 SGTC_56 0957-0365 83.25 µM 0.263437684176147 0.353909325712193 no 1179 0.39610662414051 433 6752360 SGTC_1065 prochlorperazine maleate 2.48 µM 0.263224736459282 0.353987712940346 no 1180 0.396188682974422 463 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1037 k284-1091 78.7 µM 0.263195077143527 0.353998631189033 no 1181 0.396200112477551 439 3334711 SGTC_2095 5432005 200 µM 0.263155385706808 0.354013242670676 no 1182 0.396215408094756 462 783734 SGTC_353 1988-1175 58.3 µM 0.263072767919251 0.354043657181991 no 1183 0.396247246458219 428 2788357 SGTC_1710 st031758 61.5 µM 0.262277048958744 0.354336636950176 no 1184 0.396553927558771 436 5394341 SGTC_1048 3161-0300 24.5 µM 0.261139049244752 0.354755792598575 no 1185 0.396992639588194 413 2165101 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.26083806593796 0.354866682213067 no 1186 0.397108693954195 455 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2567 aureobasidin a 60 nM 0.260462969572653 0.355004894102364 no 1187 0.397253337886372 425 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2862 9027634 71.43 µM 0.258476333077049 0.355737228525608 no 1188 0.398019655978901 410 5012562 SGTC_1388 3346-4487 254 µM 0.258035424192083 0.35589983323981 no 1189 0.398189784073994 437 3345614 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.257958518700099 0.355928198238402 no 1190 0.398219460634898 453 140250 A respiratory chain inhibitor. SGTC_573 3702-0553 84.7 µM 0.257321749091618 0.356163088152399 no 1191 0.398465202127356 411 1222756 SGTC_2107 5363541 170.161 µM 0.256082635913599 0.356620325407176 no 1192 0.398943514789202 461 244052 SGTC_1484 3473-2379 286 µM 0.254115577734467 0.357346600132101 no 1193 0.399703134505274 461 671917 SGTC_2546 rhodinyl acetate 100 µM 0.2525287473994 0.357932864559438 no 1194 0.400316198370475 428 6708682 SGTC_143 4032-1194 15.74 µM 0.251120194076954 0.358453544343505 no 1195 0.400860591718368 416 1806963 SGTC_1358 1509-0022 2.48 µM 0.249754195299226 0.358958745077355 no 1196 0.401388722077237 406 3258434 SGTC_1608 st001473 40.5 µM 0.248493257755433 0.35942530907057 no 1197 0.401876393026794 462 7292267 SGTC_1150 3909-7983 10.9 µM 0.248104049347746 0.359569363837724 no 1198 0.402026951314473 428 23965914 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.247812833401149 0.359677162449955 no 1199 0.402139612487516 434 5024745 SGTC_2898 9056270 58.44 µM 0.247091340156121 0.359944283718189 no 1200 0.402418767769871 432 19154699 SGTC_3263 9137018 49.47 µM 0.244270299443774 0.360989384294303 no 1201 0.40351074222729 467 43844957 SGTC_2130 NSC 7 2.4545 µM 0.243683456651738 0.361206920551721 no 1202 0.403737993438476 447 21448 SGTC_3313 9133968 57.047 µM 0.241535523330991 0.362003518499945 no 1203 0.404570043838737 461 1494643 SGTC_647 0140-0236 81 µM 0.241192083345952 0.362130944671368 no 1204 0.404703123193113 437 990837 SGTC_2728 chlorpromazine 9.18 µM 0.241183991008537 0.362133947347021 no 1205 0.404706259021094 477 2726 A thorazine and dopamine antagonist. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.241164400738771 0.362141216385289 no 1206 0.404713850390313 459 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2614 arthonioic acid 13.39 µM 0.239847940695787 0.36262980730879 no 1207 0.405224070090286 420 6710684 SGTC_1102 cgs 12066b 26.1 µM 0.237341867348628 0.363560529168501 no 1208 0.406195792191559 426 6438352 A 5-HT1B full agonist. SGTC_1944 st076371 56.9 µM 0.237242438054183 0.363597472524386 no 1209 0.406234357551647 459 24208455 SGTC_2808 7946468 45.46 µM 0.235969587727475 0.364070517145491 no 1210 0.406728134659553 446 2970879 SGTC_2869 9037858 32.47 µM 0.232598441832265 0.365324375858211 no 1211 0.408036618684569 413 27187042 SGTC_2768 sulfasalazine 50.2 µM 0.232255492964991 0.365452012690619 no 1212 0.408169789372808 435 5384001 An antioxidant and salicylic acid derivative. SGTC_2853 9015042 58.44 µM 0.23181636877678 0.365615465282118 no 1213 0.408340321444793 438 6457456 SGTC_37 0566-0070 1.56 µM 0.227882955434049 0.3670806615218 no 1214 0.409868616859945 465 1626686 SGTC_1746 st038117 42 µM 0.227139955694548 0.367357647145329 no 1215 0.410157457872709 462 2898218 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.225013891171641 0.368150611550961 no 1216 0.410984233879734 418 6857784 SGTC_2103 5378138 10 µM 0.224597923238396 0.368305822157356 no 1217 0.411146040316447 463 244142 SGTC_2059 5238311 157 µM 0.223233582591684 0.368815050942741 no 1218 0.41167685810209 428 703021 SGTC_2588 indole-3-carbinol 100 µM 0.221805465255327 0.369348330659218 no 1219 0.41223266238582 465 3712 Induces cell cycle arrest. SGTC_2275 7947463 200 µM 0.221727585740392 0.369377419239662 no 1220 0.412262977130667 460 1225414 SGTC_1312 1218-2183 165 µM 0.220074648732097 0.369994979683764 no 1221 0.412906509093632 453 6744073 SGTC_3023 9089636 49.47 µM 0.21993323030812 0.370047831186066 no 1222 0.412961577911725 438 17249241 SGTC_2023 5144124 124 µM 0.219540147920146 0.370194748516808 no 1223 0.413114654532116 459 2830192 SGTC_1569 carminic acid 40.6 µM 0.217515387828369 0.370951816587944 no 1224 0.413903358152564 469 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1665 st014639 11.4 µM 0.216341514665581 0.371390962791743 no 1225 0.414360775584434 456 981133 YIL048W NEO1 SGTC_552 k242-0005 476 µM 0.216330206378124 0.371395194039834 no 1226 0.414365182595623 470 4088318 SGTC_380 3970-0968 6 µM 0.214801301350968 0.371967410876673 no 1227 0.414961119124637 463 2891601 SGTC_29 0299-0004 12.984 µM 0.214317998170257 0.372148353629413 no 1228 0.415149541796886 471 16871 A napthoquinone isolated from Swertia calycina. SGTC_1644 st010134 20.9 µM 0.214245474337049 0.372175508095727 no 1229 0.415177817937949 474 3818134 SGTC_3300 9124615 50.48 µM 0.214007762083866 0.372264517076975 no 1230 0.41527050206996 433 24824903 SGTC_1972 st070201 17.4 µM 0.213584952659246 0.372422850709076 no 1231 0.415435367334734 458 2829099 SGTC_297 0986-0032 24 µM 0.21124263361831 0.373300392106164 no 1232 0.416348972232168 454 2847425 SGTC_1916 st067606 49.2 µM 0.210187457159981 0.373695925280685 no 1233 0.416760684323775 446 19590279 SGTC_2329 6138490 200 µM 0.210156263576563 0.373707620230723 no 1234 0.416772856926831 443 720019 SGTC_166 k072-0058 166.424 µM 0.208684846727554 0.374259408784045 no 1235 0.417347135130634 481 5846229 SGTC_3077 9117319 49.47 µM 0.20775107120036 0.374609712924484 no 1236 0.417711669247903 464 17154678 SGTC_163 TUB2.036 7.546 µM 0.207176105302484 0.374825461813643 no 1237 0.417936163839135 467 15992207 YJR013W GPI14 SGTC_54 0159-0055 9 µM 0.206935896685435 0.37491560875415 no 1238 0.418029960865552 456 3319099 SGTC_2922 7999257 32.47 µM 0.206155862999765 0.375208391614847 no 1239 0.4183345817336 465 2988377 SGTC_1977 st070720 65.3 µM 0.204061248014321 0.375994953268454 no 1240 0.419152818360363 426 682188 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.204034317971641 0.376005069296118 no 1241 0.419163340548774 458 1377 SGTC_1606 st000094 49.2 µM 0.203340938717625 0.376265560280917 no 1242 0.419434279693163 460 1242210 SGTC_2804 7954240 19.48 µM 0.203209577686694 0.376314916777622 no 1243 0.419485613551684 437 828705 SGTC_1195 1502-0147 41.1 µM 0.202717817565545 0.376499704571398 no 1244 0.419677797958799 455 817940 SGTC_2996 9066192 71.4286 µM 0.200193475646302 0.377448716620313 no 1245 0.420664634787185 446 6472854 SGTC_254 nsc-64875 3.808 µM 0.199897191400338 0.377560151668074 no 1246 0.420780493525921 466 56993 SGTC_1397 3532-0190 20.1 µM 0.199887680181758 0.377563729087917 no 1247 0.42078421289845 439 5322280 SGTC_1214 0358-0031 63.7 µM 0.199755004400117 0.377613633039296 no 1248 0.420836096646517 461 4301366 SGTC_856 0433-0016 11.3 µM 0.198975214894097 0.377906980116584 no 1249 0.421141066288808 458 3911780 SGTC_2272 7805186 180 µM 0.197794674338978 0.378351218688564 no 1250 0.421602856559287 483 2956062 YPR165W RHO1 SGTC_3159 9100096 49.47 µM 0.197517527301635 0.378455532725017 no 1251 0.421711283401767 431 25236875 SGTC_2529 gangaleoidin 93.61 µM 0.196803009843355 0.378724507343689 no 1252 0.421990847833757 462 4565183 SGTC_900 1112-0045 141 µM 0.196010621389678 0.379022864604735 no 1253 0.422300926295056 484 56211 YIL048W NEO1 SGTC_322 k048-0136 19.3 µM 0.192727901082992 0.380259670260268 no 1254 0.42358603559153 449 6823282 SGTC_992 3909-8734 162 µM 0.191535495121306 0.380709228060446 no 1255 0.424053037094754 449 4288319 SGTC_2772 vinpocetine 57.06 µM 0.188975416533392 0.381674965831716 no 1256 0.425056042191818 479 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_662 k832-1615 104 µM 0.187725691720446 0.382146667271341 no 1257 0.425545844616484 489 5878478 SGTC_3274 9138298 49.47 µM 0.18771348113818 0.382151276949652 no 1258 0.425550630856414 442 17015756 SGTC_2703 st077852 53.4 µM 0.18576348029945 0.382887645501643 no 1259 0.426315122248268 454 6281836 SGTC_3059 1327-0034 3 µM 0.185430954487853 0.383013257811451 no 1260 0.426445515615672 433 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_893 0958-0369 48.9 µM 0.184679255950846 0.383297258804484 no 1261 0.426740308820521 472 6819948 SGTC_3015 9080845 49.47 µM 0.184577236823983 0.383335807728501 no 1262 0.426780320763565 469 5296973 SGTC_3114 9122766 49.47 µM 0.18454416574579 0.383348304206492 no 1263 0.42679329141561 431 17176985 SGTC_2379 9035213 200 µM 0.182927283476884 0.383959418876632 no 1264 0.427427537485426 479 646551 SGTC_1240 0356-0016 42.1 µM 0.181239469348228 0.384597650790138 no 1265 0.42808980775167 481 4305613 SGTC_281 1672-3440 14.9 µM 0.181128451454207 0.384639642206808 no 1266 0.428133376453657 476 6833000 SGTC_2667 digitoxin 100 µM 0.180024749606633 0.385057180015865 no 1267 0.428566569120942 459 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_457 grayanotoxin iii 135 µM 0.179161072141192 0.385384007994485 no 1268 0.428905614522095 472 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2263 7948595 193.29 µM 0.178407722497199 0.385669152826843 no 1269 0.429201392461547 458 2971371 SGTC_1474 0330-0125 5.35 µM 0.177700124212004 0.385937036935846 no 1270 0.429479243846891 475 X1474 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.17718846614632 0.386130775464917 no 1271 0.429680177501853 427 94937 An inhibitor of serotonin biosynthesis. SGTC_599 1935-0052 86.5 µM 0.176541084121857 0.386375946351317 no 1272 0.429934437523564 455 9557311 SGTC_1770 st043884 66.3 µM 0.176388708677592 0.386433659253242 no 1273 0.429994287380368 489 670149 SGTC_1080 nisoldipine 24.4 µM 0.176266910663821 0.386479792619171 no 1274 0.430042128225047 481 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2236 dapsone 200 µM 0.174111773656552 0.387296357485485 no 1275 0.430888810243644 468 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1244 0416-0015 52.5 µM 0.17335292898812 0.38758399685797 no 1276 0.431187011042755 463 96201 SGTC_1177 0983-0204 23.6 µM 0.17245112405578 0.387925905423758 no 1277 0.431541441485326 453 766818 SGTC_1749 st037932 54.2 µM 0.172380044280087 0.387952858169704 no 1278 0.431569379847909 464 594497 SGTC_21 0849-0113 22.993 µM 0.170442994560732 0.388687575592611 no 1279 0.432330881005026 452 1560156 SGTC_383 2324-0395 7.37 µM 0.169603850147709 0.389005984493432 no 1280 0.432660847220894 474 3146421 SGTC_1991 st073000 8.92 µM 0.169020115046521 0.389227523672004 no 1281 0.432890409753438 469 4301969 YIL048W NEO1 SGTC_3051 9093778 49.47 µM 0.168836119860018 0.389297361003675 no 1282 0.432962773302597 481 17217378 SGTC_3220 9131269 49.47 µM 0.168422193864177 0.389454484089591 no 1283 0.433125574656099 488 17722206 SGTC_125 0133-0007 11.75 µM 0.167705133143876 0.389726717517064 no 1284 0.433407628862037 480 26541 SGTC_2678 equilin 100 µM 0.166957321112555 0.390010683377391 no 1285 0.433701815157804 471 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1496 4469-0713 57.4 µM 0.166328126678702 0.390249652189838 no 1286 0.433949366221032 473 746691 SGTC_543 3844-1095 191 µM 0.166240419801116 0.390282966664493 no 1287 0.433983875786817 471 4230703 SGTC_102 gallobenzophenone 83.616 µM 0.165944003324991 0.390395563102859 no 1288 0.434100508947592 466 70837 SGTC_3157 9099274 49.47 µM 0.165910642815226 0.390408235965348 no 1289 0.434113635910952 487 17217662 SGTC_1946 st076057 65.1 µM 0.165598471040352 0.390526828222774 no 1290 0.434236475306273 482 953009 SGTC_1737 st035557 69.7 µM 0.163509022764301 0.391320859302766 no 1291 0.435058834807903 500 5716916 SGTC_1031 k035-0009 16 µM 0.163294454955104 0.39140242496401 no 1292 0.435143299805254 486 5180959 SGTC_746 1095-0025 46.6 µM 0.161824511397803 0.391961336550184 no 1293 0.43572202507209 496 6749286 SGTC_2308 7584454 197.62 µM 0.16160299898697 0.392045580816615 no 1294 0.435809247754308 469 893577 SGTC_3257 9139206 32.98 µM 0.161443154905289 0.392106374899275 no 1295 0.435872189867399 481 4910041 SGTC_2543 pimpinellin 60.67 µM 0.16074896963497 0.39237042745519 no 1296 0.436145559367859 480 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2343 7990716 14.84 µM 0.160735309000514 0.392375624152737 no 1297 0.436150939219234 476 6456862 SGTC_1275 0867-0008 21.1 µM 0.15703705986473 0.393783193144383 no 1298 0.437607820442731 467 3422836 SGTC_1771 st048882 4.1505 µM 0.155007874307713 0.394556100920878 no 1299 0.438407554770623 434 4580403 SGTC_2431 5490079 200 µM 0.154946084559167 0.394579642892484 no 1300 0.438431911057499 484 5722345 SGTC_2710 st078562 53.7235 µM 0.154819694799461 0.394627798748398 no 1301 0.438481732106969 489 17250908 SGTC_3178 9107506 49.47 µM 0.154015460006567 0.394934258533709 no 1302 0.438798772853602 471 8897194 SGTC_1458 k015-0034 6.33 µM 0.15388443725628 0.394984191912941 no 1303 0.438850427603122 478 3598957 SGTC_35 0133-0054 64.071 µM 0.151614160565743 0.395849678112093 no 1304 0.439745632006662 465 99677 SGTC_1387 3342-1166 1.8 µM 0.149299889145869 0.396732465001207 no 1305 0.440658501370708 463 3418228 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.149103811885601 0.396807283750811 no 1306 0.440735859033279 475 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1573 oleylamine 1.06 µM 0.148591700520884 0.397002712042527 no 1307 0.440937911164498 490 5356789 An amine of the fatty acid oleic acid. SGTC_421 streptovitacin 30 mM 0.148543820619502 0.397020984952516 no 1308 0.440956802834758 452 91467 include heat shock SGTC_1899 st063254 59.6 µM 0.146685319425512 0.397730438624913 no 1309 0.441690203327545 491 3093813 SGTC_2077 5212015 200 µM 0.146661068041644 0.397739698451698 no 1310 0.44169977471942 484 780900 SGTC_227 fluconazole 33.516 µM 0.14174996056444 0.39961607089442 no 1311 0.443638755257987 485 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_170 4197-0004 226 µM 0.140352515320889 0.400150414746199 no 1312 0.444190736842167 467 218692 SGTC_2520 obtusaquinone 4.71 µM 0.139342670087343 0.400536667672986 no 1313 0.444589686450705 505 5967872 SGTC_506 n9-isopropylolomoucine 153 µM 0.139222035783278 0.400582815268403 no 1314 0.444637348018575 492 6610355 SGTC_1167 k781-0610 148 µM 0.138239116219732 0.400958874192737 no 1315 0.445025720790288 468 4525169 SGTC_2762 leflunomide 42.06 µM 0.134991318719442 0.402202112293319 no 1316 0.446309369081256 473 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_236 1509-0011 5.31 µM 0.134252541010984 0.402485050793568 no 1317 0.446601440100038 500 3107280 SGTC_1667 st014849 34.6 µM 0.132999484699199 0.402965065441095 no 1318 0.447096894015017 496 5348460 SGTC_2247 cerulenin 830 nM 0.131266224741287 0.403629275114253 no 1319 0.447782354656236 498 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_80 0159-0065 512.242 µM 0.131077907878862 0.403701457572526 no 1320 0.447856838660343 480 1548079 SGTC_677 0929-0063 136 µM 0.130937996999691 0.403755087985746 no 1321 0.447912178084389 488 1539583 SGTC_1781 st038725 66.3 µM 0.130247958114058 0.404019619033374 no 1322 0.448185126312449 447 4270275 YIL048W NEO1 SGTC_260 nsc-65238 3.989 µM 0.129978581515101 0.404122898284477 no 1323 0.448291686197597 459 3246252 SGTC_3327 9140648 26.9345 µM 0.124627983697082 0.406175698453987 no 1324 0.450409036663296 498 8029710 SGTC_137 0438-0332 85.389 µM 0.122457386185285 0.407009205157137 no 1325 0.451268396413663 496 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1587 estradiol valerate 56.1 µM 0.121895831776258 0.407224910095086 no 1326 0.451490758386179 493 13791 A steroid. SGTC_447 ml7 120 µM 0.121632739049351 0.407325979265817 no 1327 0.451594941987209 484 4216 Selective myosin light chain kinase inhibitor. SGTC_27 0485-0001 32.618 µM 0.121594975677579 0.407340486873001 no 1328 0.451609896395625 503 2054479 SGTC_3035 9091303 49.47 µM 0.121415855021141 0.407409301636243 no 1329 0.45168082964744 496 25237002 SGTC_2120 5538279 151.968 µM 0.120316090709097 0.407831872809495 no 1330 0.452116379080888 490 2058197 SGTC_2174 5790901 200 µM 0.118834282246858 0.408401409358166 no 1331 0.45270332390485 495 786020 SGTC_879 0831-1030 162 µM 0.118427560835016 0.408557767585718 no 1332 0.452864444523961 507 1549252 SGTC_1815 st051655 58.2 µM 0.117684706131035 0.40884338500586 no 1333 0.453158742651031 494 5984156 SGTC_1570 verbenone 133 µM 0.116208462552887 0.409411123929514 no 1334 0.453743665024106 500 29025 A natural terpanoid with antifungal properties. SGTC_595 3909-8003 73.7 µM 0.115780521483947 0.409575738587108 no 1335 0.453913244142803 500 699517 SGTC_1109 tnp00067 928.257 nM 0.113733985060555 0.410363192840149 no 1336 0.454724335564317 493 676295 SGTC_2473 5854593 8.94 µM 0.113423220315842 0.410482798766496 no 1337 0.454847515674087 490 2872951 SGTC_1741 st038134 10.228 µM 0.112142552500638 0.410975784952035 no 1338 0.455355189091168 492 1272587 SGTC_3025 9087895 49.47 µM 0.111499903719401 0.411223222187195 no 1339 0.455609970972644 488 17173641 SGTC_3087 9117406 49.47 µM 0.111071798783554 0.41138807382275 no 1340 0.455779705825715 472 42546093 SGTC_596 1155-0152 116 µM 0.110223758182291 0.411714677496914 no 1341 0.45611596038339 511 280313 SGTC_1173 0443-0020 122 µM 0.109853225468701 0.411857399016237 no 1342 0.456262889307873 487 5331295 SGTC_1757 st041620 31.8375 µM 0.107485094014744 0.412769828802677 no 1343 0.45720207503288 484 5289815 SGTC_2688 kanamycin b 96.69 µM 0.107305508882524 0.412839041395589 no 1344 0.457273307161392 500 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2235 salicylic acid 500 µM 0.106293699626598 0.413229045985216 no 1345 0.457674665121088 498 338 A COX inhibitor and kinase inhibitor. SGTC_1631 benzylvanillin 81.9 µM 0.105838644779436 0.4134044760384 no 1346 0.457855187435687 468 75506 SGTC_846 0335-0850 148 µM 0.105561719787149 0.413511242987794 no 1347 0.457965049089642 484 6819598 SGTC_1464 k208-0027 110 µM 0.104949916047238 0.413747143307547 no 1348 0.458207775178794 517 X1464 SGTC_1291 0993-0025 5.79 µM 0.104939500317231 0.413751159692071 no 1349 0.458211907634925 493 4353356 SGTC_807 1315-0151 48 µM 0.104472920649113 0.413931085601302 no 1350 0.458397028427836 500 4011080 SGTC_2360 9040895 200 µM 0.103440051359438 0.414329452531713 no 1351 0.458806863113941 463 4914414 SGTC_2286 7945697 125 µM 0.102488576742072 0.414696504397967 no 1352 0.45918443977149 485 1245733 SGTC_814 3342-0569 96 µM 0.101734288579937 0.414987540285496 no 1353 0.459483792491552 506 4346283 SGTC_3007 9078383 71.4286 µM 0.10070091492749 0.415386334738175 no 1354 0.459893942530269 478 6496995 SGTC_3291 9121177 71.43 µM 0.100318871442253 0.415533793166916 no 1355 0.460045587911861 483 17015612 SGTC_2700 st077718 96.8 µM 0.0997267684023291 0.415762352387633 no 1356 0.460280624182116 483 904970 SGTC_701 4424-0219 185 µM 0.0996458767556088 0.415793579795077 no 1357 0.460312735333002 482 2911779 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0980774143838895 0.416399173811571 no 1358 0.460935410878993 492 15053 SGTC_742 0kpi-0133 140 µM 0.0962065515052681 0.417121786222127 no 1359 0.461678263802607 513 2728852 SGTC_2212 7123476 200 µM 0.0957651970730225 0.417292298312758 no 1360 0.461853529495667 505 1085715 SGTC_88 0180-0332 8.668 µM 0.0953533958674515 0.417451406890945 no 1361 0.46201706602598 503 3101745 SGTC_135 0933-0004 26.348 µM 0.0946998642249277 0.417703941151192 no 1362 0.462276612913645 520 21230617 YGL099W LSG1 SGTC_1363 1636-0063 10.4 µM 0.0944261357535816 0.417809723959011 no 1363 0.462385327613449 507 6072185 SGTC_3222 9128301 49.47 µM 0.0940641053149792 0.417949640337202 no 1364 0.462529116863011 519 4911358 SGTC_3092 9117248 49.47 µM 0.0938136378658169 0.418046446283597 no 1365 0.462628599007632 518 17141857 SGTC_3289 9119912 71.43 µM 0.093671896318459 0.41810123174903 no 1366 0.46268489779088 504 17014829 SGTC_2998 9066762 71.4286 µM 0.093545038470793 0.41815026576464 no 1367 0.462735285503261 512 4945196 SGTC_7 0192-1582 4.227 µM 0.0934287856725814 0.418195201756732 no 1368 0.462781461433863 513 252616 SGTC_1558 st069300 45.6 µM 0.0931455207897951 0.418304698545996 no 1369 0.462893977121599 508 24208000 SGTC_516 3992-2719 87.3 µM 0.0930963222427967 0.418323717019972 no 1370 0.462913519586874 463 5350887 YDR037W KRS1 SGTC_1509 1326-1131 80 µM 0.0928327134279447 0.418425622414797 no 1371 0.463018230830958 509 768313 SGTC_2414 st077232 92.9 µM 0.0924751941530098 0.418563840284449 no 1372 0.463160249477197 504 729801 SGTC_2121 5257820 149.641 µM 0.0924659622322484 0.418567409501964 no 1373 0.463163916768003 515 791256 SGTC_83 0170-0301 39.027 µM 0.0912191821262821 0.419049497361195 no 1374 0.463659216681642 502 3089716 SGTC_181 1447-1644 8.07 µM 0.0911910095375346 0.41906039215929 no 1375 0.463670409269457 497 534600 SGTC_2069 5228469 200 µM 0.0901803076531424 0.419451288001877 no 1376 0.464071966387046 512 2835210 SGTC_2201 6605497 169.863 µM 0.0894643573439846 0.419728234793957 no 1377 0.464356439340994 501 670741 SGTC_1403 3909-7815 62.9 µM 0.0867508183761753 0.420778256723702 no 1378 0.465434790709286 513 6615483 SGTC_774 k060-0086 136 µM 0.0860556144134146 0.421047361550256 no 1379 0.465711103621386 517 5911235 SGTC_2888 9058547 12.99 µM 0.0860210409206977 0.42106074548421 no 1380 0.465724845492421 492 16476514 SGTC_3038 9091290 49.47 µM 0.0859911531044747 0.421072315593816 no 1381 0.465736724988027 522 25236843 SGTC_592 k241-0073 46.5 µM 0.0851254165373664 0.421407487287822 no 1382 0.466080842083409 514 4230158 SGTC_2783 7738165 71.43 µM 0.0850367413495413 0.421441821289069 no 1383 0.466116090555742 516 17201110 SGTC_2754 granisetron 64.02 µM 0.0848252779127164 0.421523699882126 no 1384 0.466200148547168 515 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1795 st049545 62.3 µM 0.0838911133465639 0.421885448741335 no 1385 0.466571502588118 510 5291882 SGTC_2427 5545055 42.75 µM 0.0836205917972157 0.421990218689615 no 1386 0.466679047194257 496 5372858 SGTC_1258 0671-0043 57.1 µM 0.0835970300245637 0.421999344160195 no 1387 0.466688414184626 499 4298767 SGTC_723 4182-0001 115 µM 0.0830532170335542 0.422209974468011 no 1388 0.466904612332335 504 744821 YLR208W SEC13 SGTC_2296 7971656 126.45 µM 0.0808586660152905 0.423060196098518 no 1389 0.467777176011734 507 666570 SGTC_1866 st057638 64 µM 0.0797132586293922 0.423504096982473 no 1390 0.468232657075244 502 688802 SGTC_1090 efavirenz 20.7 µM 0.0784520268775019 0.423992997735443 no 1391 0.468734244777522 492 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1348 1493-0373 93.8 µM 0.0783568723667611 0.424029887950355 no 1392 0.468772089435633 516 3010129 SGTC_988 1497-1057 103 µM 0.0780882634256742 0.424134027871572 no 1393 0.468878921557732 516 3533044 SGTC_146 3448-8650 53.125 µM 0.077654866082927 0.424302067566533 no 1394 0.469051298641846 522 2891488 YIL048W NEO1 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0770426540460691 0.424539461924502 no 1395 0.469294806380733 503 279621 SGTC_129 0088-0017 176.636 µM 0.0765538556447704 0.424729020460937 no 1396 0.469489234515575 520 182446 SGTC_550 4123-0385 25.7 µM 0.0760618587796126 0.424919836957671 no 1397 0.469684942242487 508 5731123 SGTC_2558 carylophyllene oxide 100 µM 0.0756014871009682 0.425098403848471 no 1398 0.469868076658506 519 6708694 An oxygenated terpenoid and antifungal agent. SGTC_710 3448-4187 58 µM 0.0729096534601849 0.42614280662934 no 1399 0.470939006020315 497 3946412 SGTC_2985 9022375 71.43 µM 0.0726067349159633 0.426260368373298 no 1400 0.471059533590382 489 4939335 SGTC_1513 0337-0559 19 µM 0.0721486045237125 0.426438179798613 no 1401 0.471241823082131 512 775073 SGTC_1427 4048-4900 550 nM 0.0715658208700896 0.426664393758464 no 1402 0.471473720648323 520 24132586 SGTC_2655 perillic acid 100 µM 0.0706979729173405 0.427001303288169 no 1403 0.471819067089969 520 5702197 An apoptosis inducer. SGTC_3221 9128209 49.47 µM 0.0698050816549244 0.42734799053031 no 1404 0.472174401235592 518 16460723 SGTC_1724 st037281 8.293 µM 0.0686827973504559 0.427783824886568 no 1405 0.472621055794847 510 574124 YDL195W SEC31 SGTC_2082 5219693 150 µM 0.0678923582930963 0.428090841472686 no 1406 0.472935660958579 514 2834649 SGTC_819 1013-0258 27.7 µM 0.0665633590644902 0.428607139725042 no 1407 0.473464658127096 503 5753198 SGTC_1808 st050063 61.5 µM 0.0662863678176258 0.428714762502351 no 1408 0.473574918129867 529 4011993 SGTC_1086 cerivastatin 2.18 µM 0.0659069440762296 0.428862193224532 no 1409 0.473725956016253 517 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3193 9111931 49.47 µM 0.065731510913693 0.428930363738835 no 1410 0.47379579228681 510 17087244 SGTC_2181 6316240 54.2555 µM 0.0650355722347706 0.429200815219223 no 1411 0.474072838823454 504 12779990 SGTC_2513 baicalein 25.65 µM 0.0649736226799343 0.429224891293483 no 1412 0.474097500958912 513 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_361 000s-0510 1.45 µM 0.0643176336209114 0.429479851011875 no 1413 0.474358656462947 507 660 SGTC_354 2783-3500 4.88 µM 0.0638199033502718 0.429673320777676 no 1414 0.47455681499119 522 6740761 SGTC_2335 9018011 154.17 µM 0.0610229586085417 0.430760817333036 no 1415 0.475670462400102 519 6458208 SGTC_2956 9076196 2.52 µM 0.0610120450643267 0.430765061726521 no 1416 0.475674808176825 535 16423868 SGTC_1276 0871-0068 94.2 µM 0.0608700007957308 0.430820304983432 no 1417 0.475731370512797 514 3414906 SGTC_2462 5162487 171.77 µM 0.0606878484440703 0.430891148887434 no 1418 0.475803904690003 519 2259986 SGTC_3069 9117009 49.47 µM 0.0585942719835495 0.431705555673256 no 1419 0.476637636570451 525 41904981 SGTC_1832 st054113 55 µM 0.0577283441305837 0.432042488985348 no 1420 0.476982507993657 517 1251267 SGTC_617 3770-0098 35 µM 0.054402904513334 0.433336877910765 no 1421 0.47830708240842 529 5962639 SGTC_2478 5763493 32.33 µM 0.053300711019678 0.433766052523832 no 1422 0.47874615684851 520 1365576 YLR208W SEC13 SGTC_2009 4012297 12.05 µM 0.0531796708602672 0.433813188185178 no 1423 0.478794376497516 515 45595307 SGTC_2741 miltefosine 3.04 µM 0.0528008610718838 0.43396071100594 no 1424 0.478945287711674 527 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_727 3032-0951 202 µM 0.0521801142416587 0.434202473115194 no 1425 0.479192588940417 522 3652836 SGTC_2376 9072922 81.32 µM 0.0504729873286735 0.4348674740477 no 1426 0.47987273747455 511 17087968 SGTC_3172 9105863 49.47 µM 0.0494183570396973 0.435278391094401 no 1427 0.480292949616226 529 2348785 SGTC_1489 4065-0444 182 µM 0.049285249264031 0.435330259036805 no 1428 0.480345987307093 534 2877968 SGTC_1374 2889-5571 141 µM 0.0491003397588042 0.435402314341376 no 1429 0.480419666323647 520 2853281 SGTC_263 alizarin 107.927 µM 0.0479427997116188 0.435853431744205 no 1430 0.480880914675945 527 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2237 6667747 47.222 µM 0.0479364510145577 0.435855906194036 no 1431 0.480883444530891 529 729940 YDL015C TSC13 SGTC_773 4358-1457 44.6 µM 0.0431389915042889 0.437726461168301 no 1432 0.482795368745015 527 1186886 SGTC_938 3126-1755 342 µM 0.0413024344088721 0.438442915414034 no 1433 0.483527396175235 524 1777771 SGTC_1210 3013-0140 750 nM 0.0409520211999637 0.438579637143476 no 1434 0.483667072641399 524 905973 SGTC_1856 st057054 55.7 µM 0.0381469662175506 0.439674356353177 no 1435 0.484785252456931 529 1266018 SGTC_1500 4488-1866 171 µM 0.0377713587875654 0.439820978593449 no 1436 0.48493499022341 533 2900003 SGTC_2467 5474540 200 µM 0.0356774724697667 0.440638499461988 no 1437 0.48576976673937 528 5413519 SGTC_3216 9129716 49.47 µM 0.0322510144252339 0.441976843758028 no 1438 0.48713593684382 527 8056934 SGTC_875 0709-0210 25.7 µM 0.031818440006484 0.442145850933778 no 1439 0.487308420541392 538 6251364 SGTC_1615 st002656 86.5 µM 0.0316742692221452 0.442202180917349 no 1440 0.487365907387 532 1584458 SGTC_1226 3909-7979 35.4 µM 0.0310246257258065 0.442456022189549 no 1441 0.487624950316921 535 6615510 SGTC_1855 st056195 39.6 µM 0.0290619504006958 0.443223059750613 no 1442 0.48840759107609 535 4028379 SGTC_2452 5863136 48.41 µM 0.0288625280559012 0.443301008404047 no 1443 0.488487115720873 532 2184096 SGTC_3244 9134489 49.47 µM 0.0286507655028342 0.443383782903977 no 1444 0.488571561833186 532 16584271 SGTC_623 k072-0108 16.9 µM 0.0280539120269864 0.443617096396514 no 1445 0.488809576232601 533 5382803 SGTC_769 0302-0231 76 µM 0.0274114387916235 0.443868264760248 no 1446 0.489065787420685 535 571869 YER009W NTF2 SGTC_2788 5282734 71.43 µM 0.0266942294447746 0.444148677076527 no 1447 0.489351807864897 532 743706 SGTC_1753 st043925 64 µM 0.0256040135554912 0.4445749798601 no 1448 0.48978659238323 539 670181 SGTC_2664 lyso-paf C-16 73.48 µM 0.0252229681498089 0.444723993677057 no 1449 0.489938558424172 525 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_349 k015-0014 24 µM 0.0230079020837623 0.445590384252174 no 1450 0.490821984833722 531 2196908 SGTC_237 nikkomycin 200 µM 0.0219052430175395 0.446021770311011 no 1451 0.491261771228227 540 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2751 anetholtrithion 17.25 µM 0.0207380651699109 0.44647846723977 no 1452 0.491727301963801 537 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2076 5212012 200 µM 0.0203414596545135 0.44663366845483 no 1453 0.491885491299374 540 604802 SGTC_2933 9026794 32.47 µM 0.0191734966601651 0.447090767678496 no 1454 0.492351350158563 540 17586027 SGTC_442 cape 100 µM 0.0188711508142828 0.447209106579453 no 1455 0.492471946878467 541 5281787 SGTC_1265 0819-1001 68.8 µM 0.0186716355186136 0.447287199927218 no 1456 0.49255152794333 535 3106768 SGTC_2785 7756463 72.73 µM 0.0179080479192106 0.447586098681329 no 1457 0.492856104366668 542 2201551 SGTC_2256 7954252 200 µM 0.0149068172488628 0.448761187350387 no 1458 0.494053260574694 540 2972920 SGTC_3119 9125183 49.47 µM 0.0147296652692681 0.44883056281242 no 1459 0.4941239262305 542 22695334 SGTC_271 rotenone 740 µM 0.0122996455692458 0.449782353235193 no 1460 0.495093275064727 545 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0118728883352183 0.449949535547316 no 1461 0.495263514133023 545 6708514 SGTC_1353 1498-1206 8.11 µM 0.0118062734749933 0.449975632746959 no 1462 0.495290087754712 541 6756808 SGTC_2094 5332512 191.667 µM 0.0117485589148986 0.449998243318292 no 1463 0.495313110936126 543 755774 SGTC_1911 st060208 74.3 µM 0.0104186971605204 0.450519282035717 no 1464 0.495843616391494 538 688783 SGTC_84 0443-0269 128.823 µM 0.00988173745821362 0.450729686617294 no 1465 0.496057821282324 545 6150058 SGTC_2908 7930301 100 µM 0.00963041553376795 0.450828170433491 no 1466 0.496158079452262 546 2223178 SGTC_537 1334-0398 209 µM 0.00772695964859641 0.451574162631759 no 1467 0.496917419771957 539 5846986 SGTC_2919 7978188 46.38 µM 0.00770108028056302 0.451584306319047 no 1468 0.496927743838878 545 2980291 SGTC_1338 1486-1223 76 µM 0.00704459091956125 0.451841634701647 no 1469 0.4971896380787 543 3444526 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.00650822186399156 0.452051893775645 no 1470 0.497403613457404 546 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2925 9010536 32.5 µM 0.0060971506988968 0.452213044621378 no 1471 0.497567603867061 546 2994177 SGTC_293 4049-0273 38.5 µM 0.00525646168635583 0.45254264159333 no 1472 0.497902984844898 544 1380311 SGTC_1968 st069590 43.6 µM 0.00487652254792338 0.452691609665626 no 1473 0.498054556684899 547 6384066 SGTC_2280 7785178 200 µM 0.00462380853890848 0.452790698484149 no 1474 0.498155373850247 543 2954328 SGTC_3337 9144342 33.5465 µM 0.00408249078183256 0.453002958324489 no 1475 0.49837132634189 546 17682949 SGTC_2603 homopterocarpin 100 µM 0.00364642567520409 0.453173956591062 no 1476 0.49854528984956 547 101795 A weak amylase inhibitor. SGTC_2576 guaiol 23.12 µM 0.00310139507262253 0.453387696716451 no 1477 0.49876272436079 547 227829 SGTC_117 lucigenin 22.078 µM 0.00296770111393585 0.453440128430819 no 1478 0.498816060287932 546 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_775 4577-0580 57.3 µM 0.00259510824348329 0.453586255117104 no 1479 0.498964702761506 546 2006902 SGTC_2560 caryophyllene 100 µM 0.00246998812521069 0.453635327214911 no 1480 0.499014618306707 545 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1233 0325-0408 14.2 µM 0.00232181742698244 0.453693440663332 no 1481 0.499073729693232 547 12874 SGTC_1202 1988-0068 29.6 µM 0.00168900883869116 0.453941643182553 no 1482 0.499326183282646 545 2850480 SGTC_142 0335-0849 62.6745 µM 0.00126007180767776 0.454109892682595 no 1483 0.499497304212604 547 3889043 YPR107C YTH1 SGTC_50 0929-0078 56.389 µM 0.00125893491308674 0.45411033863767 no 1484 0.499497757767565 548 1377751 SGTC_1158 4092-0494 91.8 µM 0.00120235833336439 0.454132531280793 no 1485 0.499520328540202 548 1148199 SGTC_187 1488-2104 32.728 µM 0.000882063203978243 0.454258172459307 no 1486 0.499648107739578 547 2852859 SGTC_2662 daunorubicin 22.37 µM 0.000362534013721665 0.454461976293762 no 1487 0.499855369857011 537 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1308 1187-1617 41.4 µM -0.000734820265046223 0.454892491947406 no 1488 0.499706849154159 549 2882570 SGTC_3336 9143619 71.43 µM -0.00100259109542487 0.454997552257248 no 1489 0.49960002408909 550 45595730 SGTC_2345 9052315 157.45 µM -0.00251732659611708 0.455591920187083 no 1490 0.498995733047892 550 6469265 SGTC_215 1287-0124 461.5 µM -0.00267550576139533 0.455653993955503 no 1491 0.498932628903755 553 5560863 SGTC_2504 purpurogallin 52.29 µM -0.00331019797712977 0.455903075161365 no 1492 0.498679424482105 550 5281571 An antioxidant. SGTC_1463 k081-0032 34.1 µM -0.00366636657538642 0.456042859019363 no 1493 0.498537334634546 544 977755 SGTC_1852 st056254 31.4 µM -0.00425576599259648 0.45627418985183 no 1494 0.498302200135023 549 442583 SGTC_2697 mebhydrolin 72.4 µM -0.00523115704500485 0.456657049397724 no 1495 0.497913079797429 553 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_699 0375-0592 111 µM -0.00562299087646205 0.456810862980836 no 1496 0.497756763018195 552 762578 SGTC_3120 9124077 49.47 µM -0.00580782406460579 0.456883421124952 no 1497 0.497683026449073 554 18774327 YGL155W CDC43 SGTC_2750 bromebric acid 70.15 µM -0.00589685591992765 0.456918371996575 no 1498 0.497647508485942 554 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1287 0971-0001 34.6 µM -0.00711574499941597 0.457396899699947 no 1499 0.497161252419307 554 4665869 SGTC_2965 9082772 38.63 µM -0.00841954013492958 0.45790882931397 no 1500 0.496641129142994 552 16459634 SGTC_303 1348-1668 34.2 µM -0.00893749238875821 0.45811222049294 no 1501 0.496434503873329 553 5380509 SGTC_1315 1237-0019 3.69 µM -0.00920676884204955 0.458217965185087 no 1502 0.496327082531989 554 825140 SGTC_2228 7354201 200 µM -0.01048079873082 0.45871831588281 no 1503 0.495818842802066 557 753451 SGTC_3231 9132313 49.47 µM -0.0122612916811105 0.45941767960168 no 1504 0.495108574898594 552 4905967 SGTC_2070 5230947 200 µM -0.0145420413458757 0.460313723453718 no 1505 0.494198769329814 558 2835538 SGTC_2037 5169046 200 µM -0.0149695218470396 0.46048169136068 no 1506 0.494028247850246 556 5718022 SGTC_1361 1608-0041 5.61 µM -0.0162986628304072 0.461003989404299 no 1507 0.493498062153626 551 X1361 SGTC_2386 9075165 157.42 µM -0.0164691590024676 0.46107099231384 no 1508 0.493430053150554 555 16452277 SGTC_1204 4049-0315 18.3 µM -0.0171393802236593 0.461334391746289 no 1509 0.493162711322323 558 588402 SGTC_693 4161-2696 114 µM -0.0177508781598847 0.461574727510578 no 1510 0.492918796063483 558 805759 SGTC_542 3381-0244 89.3 µM -0.0181470670415789 0.461730448301016 no 1511 0.492760765026717 556 1112843 SGTC_432 NS 1619 61.3 µM -0.019764163646284 0.462366103613212 no 1512 0.492115752781685 556 4552 A K+/calcium channel activator. SGTC_1945 st075991 56.6 µM -0.0204061277734806 0.462618476388405 no 1513 0.491859697806413 559 1084980 SGTC_2563 tomatine 8.54 µM -0.0234398507267632 0.463811313584945 no 1514 0.490649708723096 561 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1355 1499-0035 1.68 µM -0.0243188188127175 0.464156978538421 no 1515 0.490299151163943 564 1548538 SGTC_679 0422-0091 41.4 µM -0.0243220006906153 0.464158229900139 no 1516 0.490297882153673 557 627384 YHR062C RPP1 SGTC_105 0111-0055 734.78 µM -0.0251565694298866 0.464486459404948 no 1517 0.489965039278202 578 5179370 SGTC_649 1123-0311 367 µM -0.0267155796553212 0.465099670780226 no 1518 0.48934329339981 563 693629 YIL048W NEO1 SGTC_2880 9042983 58.44 µM -0.0271100974675734 0.465254861159534 no 1519 0.489185960553629 564 6464714 SGTC_2049 5262831 67.185 µM -0.0276452660331002 0.465465387378339 no 1520 0.488972539186888 568 763417 SGTC_1835 st008666 49.2 µM -0.0280519917161301 0.465625392817606 no 1521 0.488810342024407 564 690455 SGTC_2561 acetosyringone 100 µM -0.0280608997016077 0.465628897271642 no 1522 0.488806789650793 557 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3083 9117465 49.47 µM -0.0284773314270127 0.465792726939193 no 1523 0.488640723798259 565 16420915 SGTC_529 4076-0302 30.3 µM -0.0285040407064414 0.465803234915921 no 1524 0.48863007266116 577 5816522 SGTC_1652 st011932 78 µM -0.0287060070208154 0.465882693365422 no 1525 0.488549532716817 566 1551076 SGTC_3347 9188721 44.724 µM -0.0291998782151694 0.466077000001671 no 1526 0.488352589181832 566 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_918 glabranin 770.725 nM -0.0302498158978941 0.466490109945296 no 1527 0.487933909674092 565 124049 Also referred to as licorice root. SGTC_3350 9150499 3.57 µM -0.0307791680771843 0.466698403309614 no 1528 0.487722827007042 564 4910996 YPR165W RHO1 SGTC_1804 st050076 49.1 µM -0.0318859382654474 0.467133932736196 no 1529 0.487281506288595 557 3895976 SGTC_384 k007-0144 5.16 µM -0.0338352340489943 0.467901103045058 no 1530 0.486504269656921 567 6824886 SGTC_1898 st060199 18.6 µM -0.0349189886361995 0.468327680291089 no 1531 0.48607216955197 562 688866 SGTC_2583 asiatic acid 100 µM -0.0359840741263255 0.468746944619931 no 1532 0.485647528868195 562 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1801 st050089 28.441 µM -0.0360060618541684 0.468755600320046 no 1533 0.485638762714659 565 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3161 9100388 49.47 µM -0.0362754400522465 0.468861645075935 no 1534 0.485531366523236 563 25236368 SGTC_202 3594-0513 34.79 µM -0.0368996422387882 0.469107380078708 no 1535 0.485282512503287 570 708429 SGTC_1940 st075990 51.1 µM -0.0373399272415199 0.469280717917576 no 1536 0.485106985171014 579 1084979 SGTC_2361 9034121 116 µM -0.0374556423739466 0.46932627531076 no 1537 0.485060853783063 578 6496917 SGTC_2669 eugenol 100 µM -0.0379759997638047 0.46953114652389 no 1538 0.484853408817635 575 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1298 1079-1278 263 µM -0.038383468088405 0.469691577534341 no 1539 0.484690970911531 568 2840950 SGTC_2706 st078239 82.5 µM -0.0407263728226131 0.470614135518642 no 1540 0.483757018280686 561 15434492 SGTC_584 0986-0246 15.4 µM -0.0413768623843803 0.470870304868607 no 1541 0.483497729069845 575 53315 YDR232W HEM1 SGTC_1138 3761-0006 1.03 µM -0.0431152021785558 0.4715549394715 no 1542 0.482804850491001 568 12061087 SGTC_2935 9038016 29.96 µM -0.0432081864186541 0.471591563138088 no 1543 0.48276778968319 565 6463195 SGTC_716 1683-5115 658 µM -0.0441824080343444 0.471975293813226 no 1544 0.482379502356956 575 723597 SGTC_2131 toluylene red 5.2905 µM -0.0446623560825771 0.47216434743905 no 1545 0.482188219616803 568 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2705 st078069 42.8 µM -0.0448178326605396 0.472225591686978 no 1546 0.482126255483409 583 1530061 SGTC_784 4579-0127 173 µM -0.0459897288471453 0.472687237877889 no 1547 0.481659218220646 569 1948547 SGTC_496 calpeptin 138 µM -0.0471833431938383 0.473157477237649 no 1548 0.48118355147067 563 73364 A calpain inhibitor. SGTC_1039 k821-0043 94 µM -0.0474508502456973 0.473262870154509 no 1549 0.48107695099882 563 15992768 SGTC_520 3584-0023 682 µM -0.0474527345424738 0.473263612539842 no 1550 0.481076200119011 573 1340790 SGTC_23 0213-0011 39.996 µM -0.048089558027459 0.473514516968512 no 1551 0.480822434032804 581 627608 SGTC_2790 5423970 71.43 µM -0.0494306020664988 0.474042914087045 no 1552 0.480288070520228 572 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_852 0418-0143 439 µM -0.0494481729310648 0.474049837650425 no 1553 0.480281069321031 561 5369229 SGTC_2232 chlorophetanol 41.5365 µM -0.0503802910089285 0.474417137454867 no 1554 0.479909670967765 582 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2793 7325131 81.82 µM -0.0507476308092374 0.474561893172366 no 1555 0.479763310811152 579 4176441 SGTC_792 4534-1957 155 µM -0.0507920082616392 0.474579380995946 no 1556 0.479745629571141 573 1717904 SGTC_458 nppb 133 µM -0.0510236517150224 0.474670665530717 no 1557 0.479653336874539 572 4549 A chloride channel blocker. SGTC_2960 9079389 5.97 µM -0.0510790603402668 0.474692500796068 no 1558 0.479631260817747 581 16457355 SGTC_1860 st056228 74.6 µM -0.051950477761375 0.475035916324327 no 1559 0.479284076555163 565 688679 SGTC_420 mitomycin C 81.9 mM -0.0523232108696077 0.475182811810146 no 1560 0.479135579523126 567 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3299 9121982 43.1275 µM -0.0524310538156089 0.475225313741039 no 1561 0.479092615385915 586 17594604 YPL160W CDC60 SGTC_1881 5652484 16 µM -0.0526204970385838 0.47529997579963 no 1562 0.479017142659498 595 2255129 SGTC_2194 5927483 104.545 µM -0.0526458848382084 0.475309981530369 no 1563 0.47900702841204 568 760979 SGTC_1499 4480-0877 67.3 µM -0.052982161148149 0.475442514774483 no 1564 0.478873060544781 567 2861909 SGTC_736 0958-0254 92.6 µM -0.0540564959995752 0.475865949841061 no 1565 0.478445076350445 576 6812352 SGTC_755 1995-0008 37.3 µM -0.0561106852093635 0.476675657199351 no 1566 0.477626815892234 570 689533 SGTC_220 paclitaxel 373.376 µM -0.0562554948316982 0.476732741016892 no 1567 0.477569136317133 599 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.056322031495785 0.476758969867742 no 1568 0.477542634047137 578 5379071 SGTC_1186 1319-0216 26 µM -0.0571050007550955 0.477067625034599 no 1569 0.477230776449759 576 4565136 SGTC_2806 7952793 58.44 µM -0.0572541110974429 0.477126407550696 no 1570 0.477171387195837 574 2972490 SGTC_939 1165-0479 45.3 µM -0.0573607895095236 0.4771684627893 no 1571 0.477128898493691 581 1377347 SGTC_2290 7904846 200 µM -0.0577313096366618 0.477314532855906 no 1572 0.47698132689768 578 2962154 SGTC_871 0574-0004 149 µM -0.0577314897198463 0.477314603850802 no 1573 0.476981255174507 570 9551173 SGTC_175 3793-3120 23.7 µM -0.0577898753002689 0.477337621463787 no 1574 0.476958001520827 580 5322297 SGTC_2065 5221596 34.26 µM -0.0580892187247162 0.477455634169641 no 1575 0.476838781051963 572 788581 SGTC_1919 st067113 52.3 µM -0.0588579482911912 0.477758706001964 no 1576 0.476532626177121 580 1268243 SGTC_851 0394-0702 453 µM -0.0596725241333423 0.478079866773489 no 1577 0.476208227646138 573 762646 SGTC_2587 piperic acid 92.2 µM -0.0612989668405264 0.478721162635235 no 1578 0.475560556799252 579 5370536 SGTC_2581 avocatin a 64 µM -0.0617587312354239 0.478902454828792 no 1579 0.475377484210937 596 6710728 A skin care supplement. SGTC_2497 7-hydroxyflavone 100 µM -0.0620970895672791 0.479035877529183 no 1580 0.475242757358116 605 5281894 SGTC_1882 5615643 20 µM -0.0627270519778997 0.479284292868266 no 1581 0.474991927721787 575 2253075 SGTC_930 2810-3379 265 µM -0.0633457090960465 0.47952825798298 no 1582 0.474745609114676 613 1015764 SGTC_859 0439-0102 54.6 µM -0.0639234137109573 0.479756080558191 no 1583 0.474515604478635 580 610143 SGTC_2277 7947813 106.88 µM -0.0647125348767277 0.48006728766433 no 1584 0.474201441177545 588 1246798 SGTC_2375 9072683 200 µM -0.0665388483774766 0.480787580423108 no 1585 0.47347441484603 582 16798029 SGTC_1329 1447-1697 50.6 µM -0.0666240361197579 0.480821179771623 no 1586 0.473440505099687 583 2840515 SGTC_2879 9041815 71.43 µM -0.067030571048005 0.480981525237796 no 1587 0.473278682873198 577 4942971 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.067157388617261 0.481031545241786 no 1588 0.473228203729431 586 5377381 SGTC_1018 4259-0013 28.1 µM -0.0673308982334663 0.481099982234257 no 1589 0.473159139730131 597 6801262 SGTC_536 3852-0578 10.6 µM -0.0678664739599894 0.481311231621063 no 1590 0.472945963550903 580 2869208 SGTC_235 0330-0087 5 mM -0.0688461253049275 0.481697653159002 no 1591 0.472556051238818 577 46494818 YHR062C RPP1 SGTC_895 0964-0006 13.7 µM -0.0695364868503112 0.481969975257453 no 1592 0.472281295311157 579 6738897 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0697638920238317 0.482059680036665 no 1593 0.472190793558037 586 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_527 4476-4215 268 µM -0.069864676922006 0.482099437061615 no 1594 0.472150684067665 569 4418754 SGTC_2143 5623677 140.463 µM -0.0699206850954248 0.482121530908476 no 1595 0.472128394547791 582 5375313 SGTC_2602 kawain 100 µM -0.0705951361427799 0.482387589550268 no 1596 0.471859990776032 569 5369129 SGTC_1990 st072050 59.8 µM -0.070925931174533 0.48251808503371 no 1597 0.471728352624801 575 17233948 SGTC_2621 lithochol-11-enic acid 100 µM -0.0716608315458161 0.482808002899593 no 1598 0.471435913942352 593 6708711 SGTC_49 0717-0965 32.132 µM -0.072656928355916 0.483200977125851 no 1599 0.471039562053278 639 5889349 YGL099W LSG1 SGTC_1878 temozolomide 1 mM -0.0728079400053008 0.483260554783293 no 1600 0.470979476259065 579 5394 DNA alkylating agent. SGTC_722 3534-0461 190 µM -0.0729313113696846 0.483309227973848 no 1601 0.470930388705834 576 658262 SGTC_2183 6420625 130.508 µM -0.0731362406393066 0.483390078414465 no 1602 0.470848851503031 582 2897619 SGTC_2636 apigenin dimethyl ether 100 µM -0.0743111098651363 0.483853610907559 no 1603 0.470381418540559 603 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1806 st050005 60.3 µM -0.0747620564207267 0.484031533033479 no 1604 0.470202015941375 574 5194765 SGTC_1105 epirubicin 18.1 µM -0.0748017120965944 0.484047179435229 no 1605 0.47018623979007 595 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_114 0364-0001 490.298 µM -0.0752689141879661 0.484231518865734 no 1606 0.470000377092401 589 4003655 SGTC_953 1188-0045 9.7 µM -0.0753491438778952 0.484263174662123 no 1607 0.469968460711477 584 6144426 SGTC_1398 3558-0053 112 µM -0.0755658954869694 0.484348697671814 no 1608 0.469882235157336 603 4532369 SGTC_2238 6671620 73.2395 µM -0.0762306352454369 0.484610986448516 no 1609 0.469617805095838 590 729941 SGTC_1027 k015-0025 8.67 µM -0.0763193924441297 0.484646008204597 no 1610 0.469582498949546 581 3598955 SGTC_1357 1503-1303 39.5 µM -0.0765053354041817 0.484719377837037 no 1611 0.469508534689737 582 292895 SGTC_1121 fusaric acid 630.51 nM -0.0771949138193296 0.484991477146933 no 1612 0.469234243879552 589 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1780 st038448 24.544 µM -0.0779436659253162 0.485286933590042 no 1613 0.468936432328245 628 728868 YDL195W SEC31 SGTC_340 k038-0059 454 µM -0.0785452985906556 0.485524342785879 no 1614 0.46869714921601 583 23733424 SGTC_976 1348-1067 47.6 µM -0.078633763092942 0.485559252040478 no 1615 0.468661965805586 579 5310671 YGL099W LSG1 SGTC_2158 5657123 3.6195 µM -0.0786796201319548 0.485577347873982 no 1616 0.46864372799874 632 2858827 SGTC_2137 5261020 140 µM -0.0790036145275561 0.485705201470119 no 1617 0.468514874037424 591 763655 SGTC_2371 9071574 200 µM -0.079027282431664 0.485714541277862 no 1618 0.468505461339511 582 45596039 SGTC_2534 helenine 20.12 µM -0.0809103233642899 0.48645764993803 no 1619 0.467756635013846 566 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2536 dehydroabietamide 32.04 µM -0.0825370174668137 0.487099633827899 no 1620 0.467109841529183 595 3983547 SGTC_2435 5706476 10.6 µM -0.0827785602108861 0.487194962908343 no 1621 0.467013808540853 577 5725375 SGTC_416 estradiol valerate 100 µM -0.0831218943037493 0.48733046698777 no 1622 0.466877308475065 589 13791 A steroid. SGTC_1942 st076330 65.2 µM -0.0832022204371056 0.487362169611154 no 1623 0.466845373605035 628 24208414 SGTC_3100 9120536 49.47 µM -0.0834689495339306 0.487467441179402 no 1624 0.466739332947875 614 16421196 SGTC_77 0828-0286 12.516 µM -0.0837780525856229 0.487589437821762 no 1625 0.466616449080732 591 745345 SGTC_1936 st074407 74.3 µM -0.0839255305326004 0.487647644756193 no 1626 0.466557820367879 574 809813 SGTC_403 arphamenine a 50 µM -0.0844103422509447 0.487838993204929 no 1627 0.466365092353649 576 5487158 An arginine aminopeptidase inhibitor. SGTC_2322 7413319 38.22 µM -0.0844756175700804 0.487864756681191 no 1628 0.46633914394817 583 1840400 SGTC_3322 9139058 2.11 µM -0.085827659094203 0.488398404362189 no 1629 0.465801709411864 575 4908926 YPR165W RHO1 SGTC_948 3448-0295 75.3 µM -0.0872928659148605 0.488976741547616 no 1630 0.465219362275307 587 678569 SGTC_1447 4239-0816 81.9 µM -0.0884896550394682 0.489449147848223 no 1631 0.46474375308375 589 1341554 SGTC_521 r062-0005 13.8 µM -0.0885536046622973 0.489474390983994 no 1632 0.464718340637668 582 2832033 SGTC_492 tmb-8 126 µM -0.0892324212259898 0.489742346021941 no 1633 0.464448599864517 609 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3273 9137859 49.47 µM -0.0904390387608642 0.490218655779433 no 1634 0.463969167669905 577 2377234 SGTC_1145 3546-0597 10.2 µM -0.0910643007040642 0.490465482158447 no 1635 0.463720749327657 586 875334 SGTC_277 nystatin 15.5 µM -0.093694847627396 0.491503947226233 no 1636 0.462675781635565 616 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_958 1222-0007 33 µM -0.0938924787739628 0.491581968792343 no 1637 0.462597284256481 608 7312461 SGTC_1888 azatryptophan 97.5 µM -0.0939654407653315 0.491610773082813 no 1638 0.462568304753648 595 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2394 5221648 200 µM -0.094741931179255 0.491917322432247 no 1639 0.462259905744087 604 788586 SGTC_1328 1441-0025 69.2 µM -0.0951202639279358 0.49206668552499 no 1640 0.462109651382757 601 4562601 SGTC_367 0335-0881 7.1 µM -0.0953458275524214 0.492155736978864 no 1641 0.462020071652835 599 23828853 SGTC_3207 9114163 49.47 µM -0.0959768617846518 0.492404868376765 no 1642 0.46176947466671 639 849233 SGTC_1067 clotrimazole 1.36 µM -0.0962076067865024 0.492495966913052 no 1643 0.461677844750132 585 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_512 prima-1 270 µM -0.0975413125355416 0.493022523830529 no 1644 0.461148263983532 587 322968 A re-activator of the apoptotic function of mutant p53. SGTC_405 ebelactone b 50 µM -0.0976656037967132 0.493071595575348 no 1645 0.461098914567118 580 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_747 3448-8087 38.7 µM -0.0983750641513401 0.49335170138386 no 1646 0.460817237272536 619 5168703 SGTC_2638 epoxomicin 18 µM -0.098595945588043 0.49343890943199 no 1647 0.460729544644278 604 9915668 A protesome inhibitor. SGTC_61 0978-8327 98.565 µM -0.0990901687680775 0.493634038950394 no 1648 0.460533338928649 623 6150059 YHR072W ERG7 SGTC_1935 st074532 41.6 µM -0.099428203734482 0.493767503016441 no 1649 0.460399145184162 614 2829742 SGTC_1124 fisetin 1.16336 µM -0.100758512057395 0.494292746313207 no 1650 0.459871080877222 626 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1327 1436-0082 2.18 µM -0.101734639352723 0.494678155282556 no 1651 0.459483653275759 595 15992205 SGTC_2372 9071633 200 µM -0.103062718788731 0.495202535092443 no 1652 0.458956596754448 572 21321366 SGTC_629 3448-6466 76.7 µM -0.103684353154287 0.495447984541805 no 1653 0.458709922048158 601 573744 SGTC_2242 6630449 61.2675 µM -0.104130408218433 0.495624108384707 no 1654 0.458532929878332 620 691249 YDR170C SEC7 SGTC_2787 5284540 71.43 µM -0.104780050634494 0.495880619753859 no 1655 0.458275170093594 610 736958 SGTC_638 3970-0837 4.09 µM -0.105458478998685 0.496148499073717 no 1656 0.458006007586729 593 4118451 YLR208W SEC13 SGTC_1180 1193-0155 285 µM -0.105575517216288 0.496194712117319 no 1657 0.457959575298909 605 2921347 SGTC_2061 5245884 80.95 µM -0.105651463481493 0.496224699854139 no 1658 0.457929445628463 613 573863 SGTC_2195 6536160 144.242 µM -0.106045352213842 0.496380228994553 no 1659 0.457773184582249 590 3834386 SGTC_3320 9137005 35.139 µM -0.106428815246517 0.496531642018632 no 1660 0.457621065823502 576 4908713 SGTC_1382 3002-2117 298 µM -0.10664365627351 0.496616473700173 no 1661 0.457535841675117 604 1497314 SGTC_2874 9043904 71.43 µM -0.106727498690858 0.496649579584602 no 1662 0.457502583200401 605 4463428 SGTC_2045 5106652 78.05 µM -0.106888819022862 0.496713278340696 no 1663 0.457438591749013 588 673349 SGTC_3136 9095672 49.47 µM -0.108346911032727 0.497289022436704 no 1664 0.45686025599213 583 17217380 SGTC_3132 9126706 49.47 µM -0.108410230133977 0.497314024835471 no 1665 0.456835143245515 596 850858 SGTC_1141 3253-0389 52.6 µM -0.109022909481665 0.497555950046671 no 1666 0.456592159751013 589 5402031 SGTC_862 0452-0056 10.2 µM -0.109339696059126 0.497681038119841 no 1667 0.456466531208925 588 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2380 9035439 200 µM -0.109756018578399 0.497845429841798 no 1668 0.456301436163698 596 6462575 SGTC_1146 3579-1023 7 µM -0.109844349689498 0.497880308866503 no 1669 0.456266408932056 599 X1146 SGTC_1113 artemisinin 1.17947 µM -0.110368401154895 0.498087239724929 no 1670 0.456058606113069 620 2240 An anti-malaria and mitochondrial poison. SGTC_1182 1222-0449 220 µM -0.112355861229385 0.498872027194412 no 1671 0.455270625647123 591 658318 SGTC_564 3555-0129 330 µM -0.113167539166243 0.499192535525409 no 1672 0.454948865149955 601 563260 SGTC_2679 rapamycin 1 nM -0.113538142793551 0.499338876451335 no 1673 0.454801962498951 610 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2307 7538926 6.34 µM -0.113578659217 0.499354875250636 no 1674 0.454785902668991 601 96582 SGTC_1371 2421-0008 32.7 µM -0.114061123494612 0.499545386935267 no 1675 0.454594669998767 615 2827552 SGTC_1650 st011916 45.8 µM -0.114218557783472 0.49960755336877 no 1676 0.454532270598028 593 242528 SGTC_922 1866-0035 480 µM -0.114561958760606 0.499743152919828 no 1677 0.454396166817033 630 3156169 SGTC_2786 7743617 45.45 µM -0.115016110979546 0.499922485117061 no 1678 0.454216176037834 620 583674 SGTC_712 r015-0009 80.6 µM -0.115408718146187 0.499922485117061 no 1679 0.454060584528 606 6813872 YLR060W FRS1 SGTC_956 1185-0240 191 µM -0.115855219556194 0.499746174013132 no 1680 0.453883643121559 614 1416193 SGTC_1122 capsaicin 818.572 nM -0.115967005325471 0.499702032899398 no 1681 0.453839345630572 593 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2506 ethyl hematommate 54.16 µM -0.116665283548715 0.49942630221338 no 1682 0.453562651036903 607 3940691 An allergen. SGTC_2060 5238662 140 µM -0.11709637214266 0.499256077423168 no 1683 0.453391842285361 621 790130 SGTC_3245 9134821 49.47 µM -0.118088062518437 0.49886448728391 no 1684 0.452998940999631 606 17014901 SGTC_816 0325-0417 81.3 µM -0.118260714941386 0.498796311885986 no 1685 0.45293054192265 603 68101 SGTC_2257 7960413 200 µM -0.118785142112288 0.498589231140746 no 1686 0.452722790106215 598 2974689 YIL048W NEO1 SGTC_3037 9091026 49.47 µM -0.121702659106907 0.497437198646718 no 1687 0.451567253616179 624 25236398 YIL048W NEO1 SGTC_864 0469-0573 172 µM -0.121787972671172 0.497403511372029 no 1688 0.45153346972942 631 689425 SGTC_2740 felodipine 17.08 µM -0.122171283276521 0.49725215595769 no 1689 0.45138168434379 591 3333 L-type calcium channel blocker SGTC_942 3253-1115 227 µM -0.122884167683553 0.496970664906452 no 1690 0.451099411478794 599 46497897 SGTC_2332 7982454 138.89 µM -0.123045917318177 0.496906796307045 no 1691 0.451035368721733 600 2981748 SGTC_2589 lobaric acid 100 µM -0.123341821827652 0.496789955405094 no 1692 0.450918212309627 601 73157 A novel microtubule depolymerizer. SGTC_2292 7671323 168.05 µM -0.125089629899356 0.496099821581299 no 1693 0.45022629647664 622 937504 SGTC_2707 st078556 66.6 µM -0.126481552421408 0.495550219819707 no 1694 0.449675375401395 589 17250899 SGTC_2596 sinensetin 100 µM -0.126691121712091 0.495467471917526 no 1695 0.449592436530399 611 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2755 lomerizine 42.69 µM -0.126798003098587 0.495425270148384 no 1696 0.449550138139021 605 3949 A calcium channel blocker. SGTC_1375 2910-0797 186 µM -0.126825401999827 0.495414451789232 no 1697 0.449539295094953 597 742508 SGTC_3056 9094900 49.47 µM -0.126873245974889 0.495395560773156 no 1698 0.449520361056319 609 25236784 SGTC_3152 9099253 49.47 µM -0.127275240380262 0.49523683518537 no 1699 0.449361278116536 607 25236131 SGTC_806 3966-4455 5.86 µM -0.128219628705714 0.494863950937162 no 1700 0.44898758341052 649 714982 SGTC_1414 3917-0015 5.4 µM -0.129220657446454 0.494468707576063 no 1701 0.448591525484237 603 6618702 SGTC_1638 st008370 60.6 µM -0.129604605351892 0.494317112088906 no 1702 0.4484396297196 600 24207134 SGTC_294 k038-0071 157 µM -0.130688344938836 0.493889219917027 no 1703 0.448010926327593 603 24152826 SGTC_2834 9001755 58.44 µM -0.130867119436749 0.493818635164713 no 1704 0.447940212913936 650 2989575 SGTC_3124 9127567 49.47 µM -0.131714888592607 0.493483916852991 no 1705 0.447604904364719 631 17592030 SGTC_2961 9083290 32.55 µM -0.132813502056921 0.49305016643122 no 1706 0.447170437932582 620 17741490 SGTC_468 gf-109203x 121 µM -0.13285317903728 0.493034501466234 no 1707 0.447154748140763 620 2396 A protein kinase C inhibitor. SGTC_57 miconazole 162.5 nM -0.132952872238074 0.492995141398944 no 1708 0.447115326010624 625 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_157 1348-1695 65.819 µM -0.133423225255237 0.492809441332046 no 1709 0.446929339259122 610 5380510 SGTC_96 0929-0093 37.281 µM -0.134094381022005 0.492544465043071 no 1710 0.446663971405337 609 6991579 SGTC_341 1486-1430 230 µM -0.135271129248059 0.492079885855214 no 1711 0.446198755383564 617 2054753 YPL210C SRP72 SGTC_1927 st060202 13.8 µM -0.135327182480263 0.492057756350405 no 1712 0.446176597123316 609 688887 SGTC_1237 0330-0133 46.1 µM -0.136011825246904 0.491787465181181 no 1713 0.445905966322297 629 X1237 YHR072W ERG7 SGTC_481 bay k-8644 50 µM -0.13704447208817 0.491379792121724 no 1714 0.445497821532106 656 2303 A calcium channel antagonist. SGTC_519 k048-0011 62.8 µM -0.137410262193697 0.491235385962721 no 1715 0.445353259967 608 6836379 SGTC_1733 st037357 54.9 µM -0.137820295347779 0.491073514954969 no 1716 0.445191222028273 639 1272339 YGL099W LSG1 SGTC_208 k072-0098 12.366 µM -0.137980194820368 0.491010390971589 no 1717 0.445128035030509 603 5948901 SGTC_1554 st069299 38.7 µM -0.138125372948549 0.490953078771444 no 1718 0.445070666629937 604 24207999 SGTC_2859 9028643 45.46 µM -0.138130196041112 0.490951174754734 no 1719 0.445068760762681 615 17151580 SGTC_3179 9107801 49.47 µM -0.138133534414829 0.490949856861978 no 1720 0.445067441589665 605 4818259 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.140977984506636 0.489826988160249 no 1721 0.443943667222022 599 6708630 An antioxidant. SGTC_3156 9099931 49.47 µM -0.141446467711663 0.489642058282095 no 1722 0.44375862366068 606 18111053 SGTC_2159 5658611 73.75 µM -0.141517990578315 0.489613825415794 no 1723 0.443730374321431 636 793844 SGTC_3181 9108277 49.47 µM -0.141574727382824 0.489591429222184 no 1724 0.443707965226718 623 17097298 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.14174470924368 0.489524331056589 no 1725 0.443640829290802 624 616764 SGTC_2443 5493264 126.67 µM -0.144115865088183 0.488588379379502 no 1726 0.442704488486688 637 5340055 SGTC_1673 st016611 27.3 µM -0.144148894363523 0.4885753423698 no 1727 0.442691447871987 636 5226799 SGTC_1979 st071809 45.3 µM -0.144376226165228 0.488485612398082 no 1728 0.442601694441142 648 4976333 SGTC_720 r052-1644 49.9 µM -0.145252410504036 0.488139779801196 no 1729 0.442255793532335 632 1422863 YOR257W CDC31 SGTC_1081 sertraline 6 µM -0.14676008962263 0.487544715333938 no 1730 0.441660693685412 606 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3071 9117417 49.47 µM -0.147965105129435 0.487069128759501 no 1731 0.441185153564535 630 45595590 YGL055W OLE1 SGTC_3170 9103054 49.47 µM -0.148013027154667 0.487050215626066 no 1732 0.441166243651183 637 16432970 SGTC_2990 9074105 71.4286 µM -0.148626045698474 0.486808281408341 no 1733 0.440924359887496 623 6502001 SGTC_3279 9140807 49.47 µM -0.150364720584529 0.486122121780931 no 1734 0.440238436836278 598 45595718 SGTC_443 clozapine 122 µM -0.150422296979914 0.486099400226797 no 1735 0.440215725480719 604 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3233 9132340 49.47 µM -0.151543778948212 0.485656835358424 no 1736 0.439773389490425 658 17682950 SGTC_2297 7971671 152.32 µM -0.151634115381019 0.485621187101422 no 1737 0.439737762172354 626 909016 SGTC_3070 9117005 49.47 µM -0.151958416631616 0.485493213389564 no 1738 0.439609866703726 608 8779016 SGTC_490 phenamil 164 µM -0.15215431824502 0.485415908654831 no 1739 0.439532611563279 618 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1339 1486-1321 22.7 µM -0.152303197571919 0.485357159750742 no 1740 0.439473901522788 627 3469382 SGTC_3276 9139060 49.47 µM -0.153316264613701 0.48495740436833 no 1741 0.439074437501597 642 4870619 SGTC_2349 9023730 187.07 µM -0.154441382223867 0.484513451663814 no 1742 0.438630863378151 634 4126287 SGTC_2698 st077697 67.5 µM -0.156218176872796 0.483812397344729 no 1743 0.437930524780403 611 3154499 SGTC_787 4152-0075 138 µM -0.157215409300871 0.483418949855606 no 1744 0.437537542226017 600 9566539 SGTC_2363 9053361 176 µM -0.15738731686247 0.483351127169317 no 1745 0.437469804281314 639 6469797 YMR079W SEC14 SGTC_110 0850-0284 111.64 µM -0.15803322770276 0.483096300302106 no 1746 0.437215307888828 601 3906265 SGTC_2485 5633444 17.78 µM -0.158249216956842 0.483011089047231 no 1747 0.43713021139802 613 5724239 SGTC_825 1988-2224 89.6 µM -0.159062911103216 0.482690080543621 no 1748 0.436809654393932 622 1180859 SGTC_2704 st078022 71.1 µM -0.159114487869821 0.482669733494544 no 1749 0.436789336983585 657 54697681 SGTC_2463 5473429 200 µM -0.160626614827738 0.482073219262461 no 1750 0.436193745740839 633 5399405 SGTC_1253 0550-0034 176 µM -0.160851662146006 0.481984444448481 no 1751 0.436105117228731 610 5969915 SGTC_198 3454-2873 16.191 µM -0.162158604171255 0.481468910511123 no 1752 0.435590478684191 646 710957 SGTC_1093 fluphenazine 7.97 µM -0.164279968225894 0.480632187514935 no 1753 0.434755375242579 648 6602611 An atypical antipsychotic. SGTC_824 1304-0008 100 µM -0.165119541718254 0.480301060526982 no 1754 0.434424946031407 622 768245 SGTC_2399 5884133 200 µM -0.165946356389228 0.479974978889198 no 1755 0.434099583047577 636 722445 SGTC_2359 9039622 200 µM -0.167567001842084 0.479335862975916 no 1756 0.43346196639677 616 6463596 SGTC_2857 9024691 58.44 µM -0.167945886340624 0.479186454113632 no 1757 0.433312925349334 668 16478292 SGTC_98 0074-0023 107.663 µM -0.169024476449994 0.478761140257046 no 1758 0.432888694482411 668 3563821 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.169833543206348 0.478442121747458 no 1759 0.432570523227144 659 689007 SGTC_2424 5537928 59.2 µM -0.170941000487483 0.478005469000091 no 1760 0.432135078689538 627 5382802 SGTC_1134 3477-0009 42.5 µM -0.171032901671908 0.477969235007603 no 1761 0.432098947476631 598 3973534 SGTC_1270 0831-1170 17.3 µM -0.171840783797758 0.477650718203017 no 1762 0.431781350786154 615 6764716 SGTC_3302 9125395 16.351 µM -0.171940079440222 0.477611570736855 no 1763 0.431742318467215 637 17599668 SGTC_2438 5259590 200 µM -0.172740529523275 0.477295999931441 no 1764 0.431427692343862 631 1201127 SGTC_642 0335-0876 158 µM -0.17318710038407 0.477119949248009 no 1765 0.431252181415891 609 6812350 SGTC_3311 9131146 2.8755 µM -0.175487710601372 0.476213056070325 no 1766 0.430348213230984 634 4900406 YPR165W RHO1 SGTC_3019 9081971 49.47 µM -0.176522585619605 0.475805151546071 no 1767 0.429941703258781 639 16451803 SGTC_920 mycophenolic acid 780.421 nM -0.177466263968594 0.475433215031951 no 1768 0.429571081029572 627 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2127 5253358 187.912 µM -0.178005798339451 0.475220575336838 no 1769 0.429359211025542 639 20612 SGTC_1480 1070-0044 41.2 µM -0.178489924433172 0.47502977899447 no 1770 0.429169116642001 617 3124987 SGTC_1675 st018485 24.5 µM -0.178797274957564 0.474908653693963 no 1771 0.429048442537031 623 3323024 SGTC_2617 dihydrotanshinone i 20.83 µM -0.179133779657311 0.474776041539003 no 1772 0.42891632932158 610 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2096 5468907 200 µM -0.179728394611304 0.47454171830831 no 1773 0.428682900369995 613 759785 SGTC_270 tamoxifen 5.46 µM -0.179816340119494 0.474507061877113 no 1774 0.428648377575633 643 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2078 5212016 200 µM -0.18061116045293 0.474193858116609 no 1775 0.428336397590086 627 1899708 SGTC_2951 9072950 58.06 µM -0.180778068734569 0.474128088918423 no 1776 0.428270889041715 614 16488155 SGTC_984 1492-0255 2.91 µM -0.181605417821032 0.473802087463605 no 1777 0.427946198375423 646 1585198 SGTC_1943 st076331 65.2 µM -0.181725820055837 0.4737546466689 no 1778 0.427898950940654 619 24208415 SGTC_1889 st059080 5.18 µM -0.181893330090975 0.473688645114715 no 1779 0.427833219499617 644 176925 Isolated from Daphnopsis sellowiana. SGTC_2564 betulinic acid 100 µM -0.182300137178118 0.473528359817779 no 1780 0.427673595517815 673 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2916 7875993 68.79 µM -0.182681970063237 0.473377918457874 no 1781 0.427523781745036 647 1299250 SGTC_2696 st077691 74.316 µM -0.182897962107293 0.473292819723292 no 1782 0.427439040964764 654 757133 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.18323375388913 0.473160523495643 no 1783 0.427307305457572 607 2724 A muscle relaxant with antifungal properties. SGTC_3127 9126946 49.47 µM -0.185192987595814 0.472388678368521 no 1784 0.426538834524673 660 27243249 SGTC_2800 7887935 81.82 µM -0.185363336435759 0.472321573864818 no 1785 0.42647203167087 651 2961002 SGTC_2015 5119600 184 µM -0.18590484459722 0.472108266007858 no 1786 0.426259691496346 651 2828786 SGTC_3242 9133940 49.47 µM -0.186037106899455 0.472056167197019 no 1787 0.426207831072489 657 17248444 SGTC_3310 9130229 44.1445 µM -0.186410811191736 0.471908965713636 no 1788 0.426061307458657 651 7761258 SGTC_72 0744-0168 198.391 µM -0.189089823602264 0.470853820850636 no 1789 0.425011208600331 694 677577 SGTC_1851 st056236 18.9 µM -0.189721565147244 0.470605035245799 no 1790 0.424763660587379 625 5393171 SGTC_107 0358-0022 2.6945 µM -0.190177386279538 0.470425535829894 no 1791 0.424585065433237 673 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3106 9121286 49.47 µM -0.190885124532026 0.470146845001631 no 1792 0.424307797393026 617 15943471 SGTC_3067 9117431 49.47 µM -0.190913574287345 0.470135642455877 no 1793 0.424296652518081 650 17150885 SGTC_480 am 92016 50 µM -0.191716401173466 0.469819526318946 no 1794 0.423982179010661 682 2129 K+ channel blocker. SGTC_2216 7189485 200 µM -0.192431920501031 0.469537803889542 no 1795 0.423701945333636 641 731273 SGTC_68 0986-0284 82.829 µM -0.192611032053541 0.469467284427431 no 1796 0.423631802193293 601 423278 YIL048W NEO1 SGTC_79 0052-0007 94.094 µM -0.193509824924962 0.469113427902171 no 1797 0.423279856149585 629 2801472 SGTC_1759 st043059 70 µM -0.193649883996128 0.469058288559694 no 1798 0.423225017833048 660 669426 SGTC_606 k015-0008 38.6 µM -0.193665055448435 0.469052315801836 no 1799 0.423219077736523 656 1970475 SGTC_2677 mitomycin C 100 µM -0.19396105834164 0.468935785597381 no 1800 0.423103186870121 632 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1444 4112-3581 28 µM -0.19452176109719 0.468715055845816 no 1801 0.42288367912676 618 2877249 SGTC_3334 9142812 21.919 µM -0.194743671396296 0.468627699902624 no 1802 0.422796810776269 639 45283678 SGTC_364 0083-0097 67.7 µM -0.195018520773875 0.468519506357967 no 1803 0.42268922425502 649 5207356 SGTC_1998 st075797 76.8 µM -0.195832757746851 0.468198998354639 no 1804 0.422370534748431 652 24208315 SGTC_200 k038-0079 37.545 µM -0.196295113764437 0.468017010371992 no 1805 0.422189592824062 631 3436683 SGTC_694 1315-0438 43.2 µM -0.196854232202985 0.46779694465852 no 1806 0.421970805096393 662 6793154 SGTC_1820 st053765 18.6 µM -0.19717332210825 0.467671357163964 no 1807 0.421845953332305 636 3690829 SGTC_3142 9086498 49.47 µM -0.198460286075323 0.467164866312597 no 1808 0.42134247691875 668 25236367 SGTC_3251 9135047 49.47 µM -0.199364076234533 0.466809207080151 no 1809 0.420988979700945 635 17682963 SGTC_1912 st060209 90.8 µM -0.199432772465461 0.466782174840056 no 1810 0.420962113314365 666 688787 SGTC_375 3970-0961 9.27 µM -0.199700287270264 0.46667690816164 no 1811 0.420857494545115 632 2898222 SGTC_13 0199-0087 65 µM -0.20034322091276 0.46642392427487 no 1812 0.420606081139578 623 4589825 SGTC_1669 st015249 58.4 µM -0.200563330334498 0.466337317924514 no 1813 0.420520016769871 643 722793 SGTC_2097 5376186 200 µM -0.20082942217038 0.466232621024002 no 1814 0.42041597801808 635 742755 SGTC_487 nimodipine 119 µM -0.201130488687783 0.466114165749869 no 1815 0.420298271284735 643 4497 L-type voltage-gated calcium channels inhibitor SGTC_2779 methotrexate 400 µM -0.203007944114411 0.465375544979861 no 1816 0.419564411497823 649 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_12 0849-0099 9.267 µM -0.2031611278434 0.46531528529742 no 1817 0.419504547346803 619 6071388 SGTC_648 0375-0473 33.3 µM -0.203611279429571 0.465138208489389 no 1818 0.419328639041094 650 1713139 SGTC_1986 st071812 45 µM -0.204200626163586 0.464906386716825 no 1819 0.419098361029022 644 11838594 SGTC_2895 9054447 58.44 µM -0.204745264252256 0.464692161847374 no 1820 0.418885576856195 617 2697450 SGTC_2249 haloperidol 116.36 µM -0.204840715481792 0.464654618652098 no 1821 0.4188482875416 649 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_268 camptothecin 39.6153 µM -0.205866684127936 0.46425110118606 no 1822 0.418447525106842 647 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3095 9117207 49.47 µM -0.206273194139219 0.46409122936172 no 1823 0.418288758124572 620 17015229 SGTC_1438 4092-1045 4 µM -0.206777696957055 0.463892827096256 no 1824 0.418091737483159 639 1351342 SGTC_674 0498-0004 451 µM -0.208601580213079 0.46317563665332 no 1825 0.417379638441357 643 4231473 SGTC_2020 4017018 200 µM -0.208962317648076 0.463033800973909 no 1826 0.417238827679093 662 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_459 nigericin 15.3 µM -0.209111517296528 0.462975139642255 no 1827 0.417180591978378 683 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3146 9095609 49.47 µM -0.209277630949414 0.462909829121412 no 1828 0.417115756530379 641 17173999 SGTC_1728 st035614 33.7865 µM -0.209333635563587 0.462887810142014 no 1829 0.41709389800275 650 15945546 SGTC_1508 1080-0625 72.9 µM -0.209363098616917 0.46287622638561 no 1830 0.417082398714453 621 767111 SGTC_676 falcarinol 140 µM -0.211336190869168 0.462100553394111 no 1831 0.416312472189991 659 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2555 cholic acid 100 µM -0.211910118761518 0.461874954598137 no 1832 0.41608857811977 641 6708657 Influences liver metabolism. SGTC_2050 5263056 171 µM -0.212047999267485 0.461820758540821 no 1833 0.416034793835177 659 763468 YGL055W OLE1 SGTC_1640 st009078 66.4 µM -0.212231067704205 0.461748801766735 no 1834 0.415963385119607 659 690618 SGTC_3016 9080866 49.47 µM -0.213782420999811 0.461139078231625 no 1835 0.415358367030203 669 17066299 SGTC_283 0987-0079 11.7 µM -0.214407458779781 0.460893447320365 no 1836 0.415114662822723 640 411556 SGTC_2204 7233102 200 µM -0.216359504599546 0.460126417704543 no 1837 0.414353764656449 658 2172480 SGTC_2367 9070478 135.38 µM -0.217517894546735 0.459671314231621 no 1838 0.41390238149658 629 572802 SGTC_2021 4019055 173 µM -0.221035479956025 0.458289666046566 no 1839 0.41253240356113 654 44827708 YER133W GLC7 SGTC_628 1636-0253 16 µM -0.221274956518157 0.458195621823294 no 1840 0.412439174247175 667 4456143 SGTC_1421 4029-0249 71.4 µM -0.221664859542073 0.458042509021183 no 1841 0.412287393799683 663 2894095 SGTC_19 0279-0214 38.434 µM -0.221933352576323 0.457937076881763 no 1842 0.412182883146283 624 3566274 YBR002C RER2 SGTC_1522 st012842 45.6 µM -0.222210391307031 0.457828292111429 no 1843 0.41207505261671 652 3491067 YOR116C RPO31 SGTC_857 0438-0306 1.35 µM -0.223237704780826 0.457424924675152 no 1844 0.411675254056779 629 4686136 SGTC_314 1671-0008 2.74 µM -0.223321249083922 0.457392123512592 no 1845 0.411642745229168 671 3913060 SGTC_1435 4092-0789 56.7 µM -0.225449117193622 0.456556778427242 no 1846 0.410814952494628 645 2248285 SGTC_2684 capsaicin 100 µM -0.225895108390903 0.456381718216217 no 1847 0.41064150121993 666 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_64 000l-0018 272.079 µM -0.226084550203575 0.456307361183494 no 1848 0.410567830334158 651 6811119 SGTC_557 1315-0110 16.2 µM -0.226493061715455 0.456147023207755 no 1849 0.410408977493515 640 6833801 SGTC_1481 3346-2004 36 µM -0.226980437801205 0.455955740769734 no 1850 0.410219476786472 656 2770522 SGTC_1941 st076221 61.8 µM -0.227035274481594 0.455934219436938 no 1851 0.410198156596634 623 2828568 SGTC_2600 tangeritin 87.95 µM -0.227679745883363 0.455681298377511 no 1852 0.409947609683662 672 68077 A bioactive flavone. SGTC_2839 9003951 25.97 µM -0.227973314901635 0.455566093957489 no 1853 0.409833492965633 654 2990634 SGTC_2334 9017922 200 µM -0.228392114865614 0.4554017519976 no 1854 0.409670709452596 640 3163164 SGTC_996 3970-0799 1.8 µM -0.228404534811732 0.455396878383169 no 1855 0.40966588217672 647 6615648 YGL040C HEM2 SGTC_2382 9035899 200 µM -0.2290235483068 0.455153984632728 no 1856 0.409425306797125 687 6462679 SGTC_2937 9044753 11.33 µM -0.229770380052148 0.454860958798295 no 1857 0.40913510112656 621 6465530 YGL099W LSG1 SGTC_1306 1185-0270 9.02 µM -0.229777004604445 0.454858359708098 no 1858 0.40913252716472 645 1548076 SGTC_1833 st055984 71 µM -0.231610813966466 0.454138953948834 no 1859 0.40842015377686 638 676288 SGTC_2663 amphotericin b 100 µM -0.23188265925662 0.454032321439619 no 1860 0.408314576696339 663 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1813 st051246 8.6015 µM -0.232103595161719 0.453945660800624 no 1861 0.408228776293926 641 5291959 SGTC_3329 9141233 27.5565 µM -0.232567853620747 0.4537635656579 no 1862 0.408048495980784 678 4909101 YNL103W MET4 SGTC_1114 scopoletin 1.73284 µM -0.232682159870398 0.453718733041825 no 1863 0.408004111693522 661 5280460 A coumarin with genotoxic properties. SGTC_1058 3448-5425 97.3 µM -0.233865890787158 0.453254490901612 no 1864 0.407544547079736 644 7279705 SGTC_1236 0330-0013 258 µM -0.234598277858896 0.452967291234354 no 1865 0.407260273162188 668 4617066 SGTC_2623 humulene 100 µM -0.236039339131318 0.452402262675119 no 1866 0.406701072133715 658 6187145 An anti-inflammatory. SGTC_1690 st023502 41.2 µM -0.236277054346046 0.452309065677343 no 1867 0.406608845450172 634 24207482 SGTC_16 erodoxin 22.806 µM -0.239807648327182 0.450925197287568 no 1868 0.405239688727081 672 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2357 9067248 200 µM -0.240744690102016 0.450558009385557 no 1869 0.404876499865639 682 9150235 SGTC_317 4495-0002 170 µM -0.242342985596244 0.449931801316059 no 1870 0.404257204281178 663 15991618 SGTC_901 1112-0062 60.1 µM -0.242426713262262 0.449899000453974 no 1871 0.404224768709247 645 1908457 SGTC_804 1595-0054 20.9 µM -0.242702363837446 0.449791014953544 no 1872 0.404117988060584 684 761523 Stimulates phospholipase C. SGTC_605 1315-0399 119 µM -0.243255310030263 0.449574410727902 no 1873 0.403903811056832 652 24020461 SGTC_2959 9079155 11 µM -0.243690770959573 0.44940383928159 no 1874 0.403735160818219 658 16189457 SGTC_2882 9058044 58.44 µM -0.243724047156567 0.449390805272332 no 1875 0.403722273971557 672 18076804 SGTC_1564 D-Arginine 115 µM -0.244732089207138 0.448995989542704 no 1876 0.403331939919227 702 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2889 9059656 51.95 µM -0.244739781559118 0.448992976904147 no 1877 0.403328961656319 663 3949838 SGTC_3356 9151811 4.48 µM -0.245710993625999 0.44861263435687 no 1878 0.402952980686684 641 1859254 YPR165W RHO1 SGTC_343 4130-2827 29.8 µM -0.246582552485838 0.448271357831244 no 1879 0.40261565438325 651 1118244 SGTC_1140 3229-1848 2.98 µM -0.246907612148192 0.448144083923634 no 1880 0.402489862523187 679 2849525 SGTC_2968 9090663 33.37 µM -0.24779502408947 0.447796653737489 no 1881 0.402146502545645 703 25236811 SGTC_2126 5251174 33.877 µM -0.24809168997498 0.447680515149706 no 1882 0.402031732554315 669 790722 SGTC_1980 st071811 45.7 µM -0.249529181562852 0.44711783048084 no 1883 0.401475735503309 687 4974850 SGTC_764 1951-2361 146 µM -0.250471168299787 0.446749161456686 no 1884 0.401111499294239 663 5438930 SGTC_3260 9137109 49.47 µM -0.25266600205038 0.445890339869554 no 1885 0.400263161002781 670 17478346 SGTC_3014 9081533 49.47 µM -0.252742112660357 0.44586056290266 no 1886 0.400233751452152 696 21367265 SGTC_1092 toremifene 6.32 µM -0.253036111077927 0.445745543948577 no 1887 0.400120154190947 702 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1462 k081-0014 26.5 µM -0.253109375229497 0.445716882034928 no 1888 0.400091847166582 683 3270634 SGTC_1660 st012960 28.1 µM -0.253367045000993 0.44561608043663 no 1889 0.399992295628741 687 24207266 SGTC_2611 pyromycin 23.93 µM -0.253725205660762 0.44547597218194 no 1890 0.39985392991229 657 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1009 4106-0057 9.87 µM -0.254543686911069 0.445155817493338 no 1891 0.399537778967964 658 2928005 SGTC_197 4544-0043 41.561 µM -0.255952016144975 0.44460502345927 no 1892 0.398993944454727 654 896523 SGTC_553 k007-0256 45.7 µM -0.256376581729012 0.444438997855374 no 1893 0.39883003439244 666 6287000 SGTC_1826 st055655 41.6 µM -0.257190742215177 0.444120649164463 no 1894 0.39851576516823 649 676168 SGTC_1320 1313-0481 95.3 µM -0.258780757119036 0.443499034152073 no 1895 0.397902202925825 673 6813365 YLR208W SEC13 SGTC_1356 1502-0781 85.8 µM -0.26054715428759 0.442808625693213 no 1896 0.397220873509406 659 567702 SGTC_1219 1469-0211 33.1 µM -0.262211814643307 0.442158140639167 no 1897 0.396579072608228 692 6822282 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.262390112944736 0.442088477755072 no 1898 0.396510347228037 713 6728940 SGTC_2083 5306046 65.942 µM -0.263491051554212 0.441658370062095 no 1899 0.396086059885154 670 539837 SGTC_3078 9116413 49.47 µM -0.263691688981367 0.441579993703359 no 1900 0.396008750087641 648 17177322 SGTC_3085 9117376 49.47 µM -0.264425639361292 0.441293305200905 no 1901 0.395725978522634 665 16480349 SGTC_635 k038-0028 24.7 µM -0.267042350470628 0.44027144249827 no 1902 0.394718276865216 685 4035102 SGTC_3241 9133421 49.47 µM -0.267770733439053 0.439987069111552 no 1903 0.394437899821416 666 17018221 SGTC_1212 0520-0165 585 µM -0.268406727765085 0.439738791169508 no 1904 0.394193130723324 746 5403258 SGTC_173 1273-0061 2.693 µM -0.268747328144772 0.439605838146604 no 1905 0.394062064261683 675 2847414 YPL266W DIM1 SGTC_167 3672-0051 66.205 µM -0.270937663619796 0.438751006232345 no 1906 0.393219488324616 673 3237971 SGTC_2224 6650123 117.647 µM -0.272937369541527 0.437970821462322 no 1907 0.392450679976958 666 2908370 SGTC_2515 chrysin 20.77 µM -0.275023179641037 0.437157300046652 no 1908 0.39164921497982 668 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_318 1488-0629 67.2 µM -0.275140497891003 0.437111550667618 no 1909 0.391604149488948 679 3662576 SGTC_377 3970-0964 33.1 µM -0.275802001380899 0.436853606780807 no 1910 0.391350073217171 651 16481235 SGTC_273 hydroxyurea 18.1 mM -0.275901711970483 0.436814728378594 no 1911 0.391311779485118 664 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1523 st012844 44.7 µM -0.276402037749903 0.436619654339813 no 1912 0.391119645883221 689 4274103 SGTC_2778 tioconazole 65.09 nM -0.277056864251531 0.436364364683765 no 1913 0.390868221527125 686 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2907 7721985 69.9 µM -0.277729833499871 0.436102029542037 no 1914 0.390609878684653 658 3267881 SGTC_3213 9129884 49.47 µM -0.277802449094603 0.436073724395701 no 1915 0.39058200552645 688 17190742 SGTC_2315 7733312 200 µM -0.27816142395003 0.435933802848747 no 1916 0.390444222961155 670 726316 SGTC_2034 5197015 53.07 µM -0.278401277986897 0.435840316790786 no 1917 0.390352169291935 718 780676 SGTC_441 propafenone 146 µM -0.278491400204976 0.435805191475211 no 1918 0.390317582841053 649 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2618 avocadyne 43.43 µM -0.278609062461727 0.435759333136402 no 1919 0.390272428580487 658 3015189 SGTC_2986 9022445 71.43 µM -0.279298016936329 0.435490833563815 no 1920 0.39000806400873 702 6459286 SGTC_2822 7994718 71.43 µM -0.280088230075518 0.435182908049403 no 1921 0.389704907250185 680 1018011 SGTC_3094 9117742 49.47 µM -0.282479657623469 0.434251271109783 no 1922 0.388787871290627 666 17149698 SGTC_2383 9036125 200 µM -0.28303305389447 0.434035734378482 no 1923 0.38857574958233 678 79580 SGTC_1793 st048256 72.231 µM -0.283578798042508 0.433823197200179 no 1924 0.388366593536504 671 672022 SGTC_1085 doxorubicin 7.67 µM -0.283830649472081 0.433725121438096 no 1925 0.388270082571615 692 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_438 sphingosine 6.67 µM -0.283869360165992 0.433710047115371 no 1926 0.388255249015128 660 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2531 methyl deoxycholate 70.07 µM -0.284373479019475 0.43351374711617 no 1927 0.3880620905283 700 16667744 Haematoxylin. SGTC_3140 9094243 49.47 µM -0.284928446766695 0.433297665915306 no 1928 0.387849480769163 694 19291112 SGTC_612 0302-0167 22.4 µM -0.285200758694735 0.433191646341762 no 1929 0.38774516956762 670 235821 SGTC_42 0133-0086 60.653 µM -0.285621904091776 0.433027690701557 no 1930 0.387583862503165 700 162923 Model of phenazepam hydroxylation. SGTC_2413 inermin 26.06 µM -0.285689034621297 0.433001557255175 no 1931 0.387558151967166 702 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2085 5307070 144.047 µM -0.286473503730231 0.432696190656178 no 1932 0.387257742212504 694 2840351 SGTC_160 3453-0671 289.699 µM -0.286740500881972 0.43259226708951 no 1933 0.387155511957836 710 5322268 SGTC_2029 5175081 200 µM -0.286781910878647 0.432576149452843 no 1934 0.387139657229249 673 1380876 SGTC_3292 9120825 59.784 µM -0.287706912686906 0.432216148696026 no 1935 0.386785549052524 675 24824900 SGTC_1696 st025591 34.7925 µM -0.288416345912552 0.431940083026116 no 1936 0.386514028435508 664 2787147 SGTC_1717 st033143 58.0435 µM -0.289735241592322 0.431426942282493 no 1937 0.386009396636585 703 674616 SGTC_2936 9038235 15.59 µM -0.29147348248733 0.430750824401715 no 1938 0.38534461088887 658 4749415 SGTC_130 0136-0219 337.655 µM -0.291529943201514 0.430728866454286 no 1939 0.385323023270763 712 234244 SGTC_1033 k072-0102 21.3 µM -0.292558896291107 0.430328737332077 no 1940 0.384929667842273 695 5965931 SGTC_1161 k007-0610 110 µM -0.293288546005796 0.430045041673201 no 1941 0.384650803936635 685 5843850 SGTC_1020 4335-0961 93.3 µM -0.293910768511005 0.42980314339089 no 1942 0.384413044634379 711 669075 SGTC_2068 5226020 147 µM -0.293988596897491 0.429772888296662 no 1943 0.384383308454324 696 1810509 SGTC_2752 diclazuril 33.15 µM -0.295054520140818 0.429358561677799 no 1944 0.383976115750527 678 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2033 5192550 145 µM -0.295566071241801 0.429159748285642 no 1945 0.383780743863353 653 182073 SGTC_3288 9119690 36.221 µM -0.295959527860637 0.429006844319362 no 1946 0.383630494781664 701 17595618 YKL019W RAM2 SGTC_2138 5575593 77.673 µM -0.296677509098929 0.428727852011894 no 1947 0.383356364752394 695 762213 SGTC_1049 3226-0134 66 µM -0.29755208120129 0.428388059929348 no 1948 0.383022526174022 677 5702385 SGTC_262 fenpropimorph 62.5 µM -0.297596416865861 0.428370835879784 no 1949 0.383005604831905 688 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2217 6934799 96.0675 µM -0.298081388843861 0.428182437078299 no 1950 0.38282052290711 687 675606 SGTC_2048 5246248 200 µM -0.298260921896651 0.428112697379297 no 1951 0.382752013725409 655 677046 SGTC_2218 6965428 192.983 µM -0.298355302011055 0.428076036279658 no 1952 0.382716000076604 672 675684 SGTC_797 k781-0471 270 µM -0.298468100294113 0.428032221623811 no 1953 0.382672959736733 654 23738129 SGTC_868 0527-0199 213 µM -0.299332434114726 0.427696514716843 no 1954 0.382343204782988 689 2849450 SGTC_654 1124-0271 80.9 µM -0.300021659659632 0.427428857287795 no 1955 0.382080317107616 683 5403748 SGTC_1088 bifonazole 369 nM -0.300229060102415 0.427348320854095 no 1956 0.382001220081302 686 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1843 st055809 45.5 µM -0.301872594495753 0.426710221255313 no 1957 0.381374594073485 682 16413835 SGTC_1800 st050079 29.0735 µM -0.302925382217883 0.42630157876016 no 1958 0.380973363704279 683 3645560 SGTC_427 1354-0053 47.3 µM -0.304749715370512 0.425593646317228 no 1959 0.380278391037568 710 6813657 SGTC_119 0121-0043 24.815 µM -0.305114948891347 0.425451946192752 no 1960 0.380139303078746 696 1092378 SGTC_2142 5622915 118.518 µM -0.305186903748246 0.425424030907992 no 1961 0.380111903110416 658 5322196 SGTC_2262 9014885 67.46 µM -0.306130795829805 0.425057877421719 no 1962 0.379752530556101 677 6457424 SGTC_3002 9075603 71.4286 µM -0.307147407333514 0.424663587012811 no 1963 0.379365587330155 669 20105405 SGTC_3024 9090631 49.47 µM -0.307893725566625 0.424374177171941 no 1964 0.379081600151498 657 25236383 SGTC_2987 9018338 71.43 µM -0.308842114598753 0.424006466466712 no 1965 0.378720815648555 685 5055682 SGTC_2673 kobusone 100 µM -0.31211799226625 0.422736849473036 no 1966 0.37747542661952 676 6710676 An epoxy ketone and protein crosslinker. SGTC_2726 cimetidine 79.27 µM -0.312301877281513 0.422665605650185 no 1967 0.377405556744133 696 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1950 st077106 7.18 µM -0.313431066396121 0.42222817177187 no 1968 0.376976592417536 656 13831864 SGTC_1779 st039427 55 µM -0.315779839858225 0.42131859386328 no 1969 0.37608481059956 731 1124498 SGTC_1647 st011722 22.4 µM -0.315872365325139 0.421282771331396 no 1970 0.376049694056646 700 2854783 SGTC_2326 6164455 177.58 µM -0.316705150995269 0.420960376041619 no 1971 0.375733669961287 690 2888790 SGTC_1687 st020778 55.3625 µM -0.316869227704307 0.4208968634701 no 1972 0.375671416230826 676 4259299 SGTC_1546 5-methoxyflavanone 78.7 µM -0.317353005892564 0.420709609412847 no 1973 0.375487880706692 674 147795 SGTC_1006 4099-6547 255 µM -0.318101971628152 0.420419745688972 no 1974 0.375203794055113 685 3146833 SGTC_2459 5811157 9.22 µM -0.319311333128063 0.419951791362856 no 1975 0.374745219786539 681 2870684 YBR192W RIM2 SGTC_1756 st041558 35.5 µM -0.320678841495989 0.419422779508041 no 1976 0.374226891591742 725 3955792 SGTC_2945 9067681 61.76 µM -0.322145402671452 0.418855611538423 no 1977 0.373671271866327 724 16456930 SGTC_2303 7774051 200 µM -0.323112335406393 0.418481758657108 no 1978 0.373305084302795 734 2953184 SGTC_2748 diazoxide 86.69 µM -0.323371836445143 0.418381438226636 no 1979 0.373206827995339 667 3019 A potassium channel activatior. SGTC_2440 5628896 157.78 µM -0.323782563894055 0.418222666076256 no 1980 0.373051328853722 685 5522048 SGTC_3036 9090181 49.47 µM -0.324944970878171 0.417773394518745 no 1981 0.372611360143955 674 25236586 SGTC_3344 9148862 3.898 µM -0.326057933526585 0.417343333788018 no 1982 0.372190261710812 720 4905352 SGTC_2911 7942208 15.64 µM -0.326801123509551 0.417056212207079 no 1983 0.371909154807209 691 1243384 SGTC_2892 9047358 58.44 µM -0.328009788037635 0.41658935524166 no 1984 0.3714521309564 716 6466771 SGTC_3063 1327-0034 4 µM -0.329423073223818 0.416043611029325 no 1985 0.370917965123486 696 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.331335868413289 0.415305237509319 no 1986 0.370195400446107 708 4174840 SGTC_2692 st077426 47.7 µM -0.33220821261394 0.414968595997272 no 1987 0.369866021412098 732 25238571 SGTC_1698 5-fluorocytosine 1.055 µM -0.334719108300653 0.413999979435897 no 1988 0.368918492886516 694 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1422 4031-0024 15.5 µM -0.334840934198268 0.413952996479811 no 1989 0.368872540049342 705 782427 SGTC_1385 3091-4834 14.1 µM -0.334900295740429 0.413930103758124 no 1990 0.3688501495019 687 4072814 SGTC_3256 9138902 49.47 µM -0.335204467919071 0.413812804640426 no 1991 0.368735425950638 699 17228773 SGTC_2284 7945075 39.21 µM -0.335323287548543 0.413766985845803 no 1992 0.368690614345151 696 1245402 SGTC_754 3474-0146 171 µM -0.335362766402432 0.413751762413139 no 1993 0.368675725695149 677 24762078 SGTC_1381 2324-0066 62.1 µM -0.337327226217028 0.412994411628657 no 1994 0.367935118836838 731 10885928 SGTC_1683 st010134 710 nM -0.337440790396456 0.412950639529426 no 1995 0.367892319799235 735 3818134 SGTC_3004 9076122 71.4286 µM -0.33818209997113 0.412664936290336 no 1996 0.367612982089808 722 44782551 SGTC_2007 4011539 71.82 µM -0.338777361573586 0.412435553919077 no 1997 0.36738872835251 684 45595301 SGTC_1142 3253-1408 9.78 µM -0.341094611508447 0.411542893714528 no 1998 0.36651617882276 711 256655 SGTC_2941 9056145 11.23 µM -0.341193859858072 0.411504671060274 no 1999 0.366478822691216 721 2119517 SGTC_556 4058-0063 51.5 µM -0.342126258157981 0.411145625662364 no 2000 0.366127938678536 717 6615692 SGTC_425 3825-7017 13.1 µM -0.342660442418608 0.410939956952872 no 2001 0.365926962639951 714 3397440 SGTC_304 1310-0298 97 µM -0.342915833908756 0.410841636161034 no 2002 0.365830889744215 701 1550234 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.342916582156198 0.410841348108445 no 2003 0.365830608281656 735 6708760 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.343737582412286 0.410525316893512 no 2004 0.365521822392712 744 688798 SGTC_1130 3454-2858 15.9 µM -0.344604188654701 0.41019179338507 no 2005 0.365195978192847 745 715628 YIL048W NEO1 SGTC_2271 7849410 118.62 µM -0.344689728747405 0.410158875801953 no 2006 0.36516382036532 734 972430 SGTC_509 pifithrin 175 µM -0.346078789071613 0.409624425646028 no 2007 0.364641751750841 709 4817 A p53 inhibitor. SGTC_713 1488-1073 324 µM -0.346189549396697 0.409581817092155 no 2008 0.36460013404624 712 3312542 SGTC_1169 aniline yellow 25.8 µM -0.346514663382381 0.40945675468009 no 2009 0.3644779831154 702 6051 A DNA damaging agent. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.347441536670531 0.409100262625195 no 2010 0.364129816411125 695 279621 SGTC_1467 k284-1082 293 µM -0.348236289231245 0.408794646415608 no 2011 0.363831368232802 721 3334705 SGTC_739 1486-1183 203 µM -0.349926944240358 0.408144702205969 no 2012 0.363196762643426 702 4346692 SGTC_1836 st055642 81 µM -0.350563725547971 0.407899967621597 no 2013 0.362957837132129 716 8571 SGTC_2814 7977482 42.97 µM -0.35106342457768 0.407707943116601 no 2014 0.362770383343939 707 6456762 SGTC_22 0964-0034 14.468 µM -0.351260748723707 0.407632121433314 no 2015 0.362696369522818 713 138402 SGTC_2844 9010103 25.97 µM -0.351758567923026 0.407440850089394 no 2016 0.362509666564575 751 2480525 SGTC_1735 st034310 56.75 µM -0.351919550134106 0.40737900246563 no 2017 0.362449298515702 718 871153 SGTC_3165 9101544 49.47 µM -0.3529377885154 0.406987859845309 no 2018 0.362067540179191 711 5002184 SGTC_1613 st002381 52.1 µM -0.355498596021988 0.40600457075482 no 2019 0.361108048269161 679 551167 SGTC_3205 9113483 49.47 µM -0.356357033544844 0.405675083515067 no 2020 0.360786601153313 723 17018033 SGTC_959 1222-0044 107 µM -0.357615618282677 0.405192131809739 no 2021 0.360315494298867 713 6083612 SGTC_2992 9074591 71.4286 µM -0.3590209789263 0.404653028961206 no 2022 0.359789697603038 716 17741321 SGTC_3351 9150312 21.596 µM -0.360191062022255 0.404204317663243 no 2023 0.35935212912289 697 4904905 SGTC_1892 st058411 7.36 µM -0.362012890394228 0.403505921739085 no 2024 0.358671198855384 710 3934738 SGTC_1671 st016596 74.5 µM -0.362097510248565 0.403473490268404 no 2025 0.358639582062292 685 2829167 SGTC_3027 9089541 49.47 µM -0.362658906914468 0.4032583457689 no 2026 0.358429850131051 702 9943819 SGTC_3022 9087993 49.47 µM -0.363047663431616 0.403109379447071 no 2027 0.358284639773075 692 17173644 SGTC_1132 3456-3614 2.5 µM -0.364347934319144 0.402611235232716 no 2028 0.357799104830263 723 3125502 SGTC_4 0960-0234 25.671 µM -0.365494339694752 0.402172169224912 no 2029 0.357371215637421 679 6821112 SGTC_1658 st012944 20 µM -0.366836635589401 0.401658235261324 no 2030 0.3568704392842 725 24207260 SGTC_1046 2001-0062 216 µM -0.367431827758803 0.401430404347197 no 2031 0.356648467115194 717 739778 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.36750569684648 0.401402130669455 no 2032 0.356620921613013 718 97141 SGTC_505 gw-5074 63.9 µM -0.369893879108383 0.400488323641098 no 2033 0.355730781135377 702 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_362 0310-0100 9.03 µM -0.371232476799231 0.399976364324833 no 2034 0.355232192831157 696 790235 SGTC_1971 st069429 63.5 µM -0.371724685521179 0.399788157626394 no 2035 0.355048921791506 724 1246522 YGL099W LSG1 SGTC_3345 9148410 3.559 µM -0.373359918654766 0.399163058078523 no 2036 0.354440293239905 725 4903596 SGTC_579 4491-1009 110 µM -0.373643194902188 0.399054796467101 no 2037 0.354334896435355 736 1271041 SGTC_1752 st044819 83.042 µM -0.375860507462638 0.398207659901598 no 2038 0.353510300905789 696 441209 YML126C ERG13 SGTC_1897 st060201 15 µM -0.378729479685107 0.397112265320739 no 2039 0.352444379844619 705 611878 SGTC_2210 7115885 190.385 µM -0.37887884142922 0.397055260053754 no 2040 0.352388918496581 726 2927039 SGTC_1221 2958-7315 257 µM -0.379748543962823 0.396723373902919 no 2041 0.352066040917623 712 4562705 SGTC_1269 0831-0796 3.05 µM -0.380900031230055 0.396284071328502 no 2042 0.351638714656381 732 927758 SGTC_2428 5615643 7.78 µM -0.380987155763169 0.396250837899417 no 2043 0.351606389655042 733 2253075 SGTC_276 colchicine 750 µM -0.381315039076019 0.396125774412342 no 2044 0.351484747792451 752 2833 A microtubule depolymerizer. SGTC_2833 9001315 45.46 µM -0.383553368546587 0.395272301747788 no 2045 0.350654753832991 689 2989378 SGTC_3268 9137683 49.47 µM -0.38368787847804 0.395221029206357 no 2046 0.350604898916817 739 1953228 SGTC_2746 daunorubicin 9.88 µM -0.384077334036107 0.395072586636685 no 2047 0.350460565171668 713 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1261 0712-0010 12.7 µM -0.384418701936498 0.394942485395671 no 2048 0.350334070653135 726 2840123 SGTC_3283 9109332 35.8195 µM -0.386240302030771 0.394248440282788 no 2049 0.349659354220357 705 17027281 SGTC_36 0335-0881 14.2 µM -0.386802455056149 0.394034322874191 no 2050 0.349451229780878 714 23828853 SGTC_1966 st070145 16.1 µM -0.388007750053707 0.393575348348387 no 2051 0.349005149166318 708 3748532 SGTC_2674 ligustilide 100 µM -0.389294723993896 0.393085433807767 no 2052 0.348529069372104 687 5319022 A signalling regulator. SGTC_1316 1272-0050 65.9 µM -0.391159698249184 0.39237579148848 no 2053 0.34783959796066 739 7340392 SGTC_978 1416-0512 87.4 µM -0.392553183724189 0.391845788972432 no 2054 0.347324761608888 737 6814003 SGTC_3160 9100216 49.47 µM -0.393491917223158 0.391488861258006 no 2055 0.346978096330635 719 17191039 SGTC_1962 st076595 64.5 µM -0.394240000505892 0.391204488450382 no 2056 0.346701928002973 713 279619 SGTC_2528 xanthyletin 44.79 µM -0.3947719765976 0.391002300967649 no 2057 0.34650558905005 718 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1411 3909-8223 150 µM -0.395173266675532 0.39084980264159 no 2058 0.346357510285165 739 X1411 SGTC_3166 9102297 49.47 µM -0.395472762370497 0.390735999171179 no 2059 0.346247009639495 728 25237072 SGTC_3076 9116187 49.47 µM -0.396156225318646 0.390476329477962 no 2060 0.345994891108174 726 27241210 SGTC_1345 1488-0192 31.4 µM -0.396623854381566 0.390298690198552 no 2061 0.345822429558995 738 658348 SGTC_1465 k213-0056 144 µM -0.396791552721898 0.390234991838591 no 2062 0.345760590218662 728 24048857 YMR208W ERG12 SGTC_1818 st052136 56.3 µM -0.399272469512564 0.389292988160123 no 2063 0.344846225109622 713 674169 SGTC_10 0279-0212 42.575 µM -0.399688307076103 0.389135158187684 no 2064 0.344693052740601 712 39851 YBR002C RER2 SGTC_2148 5546263 113.568 µM -0.400682228806982 0.388757992153793 no 2065 0.344327048188824 705 792097 SGTC_134 0269-0018 6.916 µM -0.401787445186159 0.388338715961019 no 2066 0.343920231316139 682 4378915 SGTC_507 nimesulide 162 µM -0.401868367600811 0.388308022243323 no 2067 0.343890451838536 727 4495 A COX2 inhibitor. SGTC_2984 9022109 38.96 µM -0.402728383843871 0.387981862855915 no 2068 0.34357402542124 742 6459207 SGTC_2971 9092186 9.93 µM -0.403698555958757 0.387614021921223 no 2069 0.343217200809798 677 25236400 SGTC_1241 0364-0022 50.8 µM -0.40417442496296 0.38743363294646 no 2070 0.343042229550152 721 4563895 SGTC_2325 6158266 200 µM -0.404990374140568 0.387124385417431 no 2071 0.342742293269202 709 3623240 SGTC_140 0062-0056 502.533 µM -0.405337112999051 0.386992991879807 no 2072 0.342614864879112 722 3758964 SGTC_2006 4011487 200 µM -0.405848984124352 0.386799046642934 no 2073 0.342426782231326 709 45595294 SGTC_3102 9121669 49.47 µM -0.407088643568178 0.386329463504178 no 2074 0.341971441980348 718 41905072 SGTC_1078 idebenone 36.1 µM -0.40731038787433 0.386245484264628 no 2075 0.341890017115912 712 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_258 haloperidol 50.781 µM -0.40756552085966 0.386148866622025 no 2076 0.341796340973366 711 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_368 fentichlor 4.58 µM -0.408020948283963 0.385976415985524 no 2077 0.341629147749857 765 7329 A pesticide. SGTC_1861 st057647 17.4 µM -0.408238254081793 0.385894139630824 no 2078 0.341549382962363 741 688668 SGTC_1502 4534-4282 27.7 µM -0.408508400905346 0.385791863755562 no 2079 0.341450232087447 744 3278949 SGTC_3194 9111903 49.47 µM -0.408938436918008 0.385629071226681 no 2080 0.341292420316557 759 17087251 SGTC_2180 6301957 200 µM -0.409333035738666 0.385479711366199 no 2081 0.341147637465516 740 845462 SGTC_508 roscovitine 141 µM -0.409607286878403 0.385375914387493 no 2082 0.341047025336952 729 160355 A CDKinase inhibitor. SGTC_1511 0906-3109 28.5 µM -0.410519665207232 0.385030661863633 no 2083 0.340712390416108 706 2882180 SGTC_1917 st066507 28.5 µM -0.414036441070886 0.383700735682374 no 2084 0.33942370960954 707 3156428 SGTC_1632 st005650 90 µM -0.414624221036768 0.383478590179536 no 2085 0.339208507137922 716 2759605 SGTC_1704 st028805 70.8 µM -0.416576190991125 0.382741138004296 no 2086 0.338494213636381 727 2876101 SGTC_44 0929-0055 61.211 µM -0.416640967079791 0.382716672936723 no 2087 0.338470519759725 693 1379590 SGTC_1225 1216-0074 20.6 µM -0.416936622037373 0.382605013933676 no 2088 0.338362382850243 723 4241466 SGTC_733 4069-0007 56.1 µM -0.418155610736638 0.382144745766132 no 2089 0.337916674018605 721 5717425 YNL287W SEC21 SGTC_1803 st050068 52.4 µM -0.419378335688366 0.381683234113326 no 2090 0.337469827248119 726 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_514 4466-0038 2.65 nM -0.419507508449307 0.381634488284134 no 2091 0.337422634226987 736 5722064 SGTC_357 1325-0123 420 µM -0.419554377756015 0.381616801712624 no 2092 0.337405511247678 756 1098503 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.420217568200607 0.381366567099932 no 2093 0.337163260937244 727 75037 A free radical scavenger. SGTC_2955 9076254 12.21 µM -0.420518268598738 0.381253123341844 no 2094 0.337053443284902 729 16459619 SGTC_1004 4084-0029 199 µM -0.420668066510324 0.381196613628375 no 2095 0.336998741338645 706 716894 YLR208W SEC13 SGTC_1098 clofazimine 15.1 µM -0.420904661000372 0.3811073659635 no 2096 0.336912350766934 723 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_987 1497-1013 404 µM -0.421052360280612 0.381051654364291 no 2097 0.336858423926067 748 1676435 SGTC_1188 1403-0014 4.57 µM -0.42117258844566 0.38100630658408 no 2098 0.336814529606314 718 9614867 SGTC_194 1486-1323 56.904 µM -0.421467964456604 0.380894903303863 no 2099 0.336706699679496 724 5178754 SGTC_706 4262-0057 46.9 µM -0.423136529985974 0.380265776944007 no 2100 0.336097825679762 729 883298 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.423357413725401 0.3801825172564 no 2101 0.336017255471013 728 688788 SGTC_624 k048-0052 28 µM -0.424738714965402 0.379661977057859 no 2102 0.33551357892787 709 6835531 SGTC_2278 7948257 134.34 µM -0.42489656453134 0.379602505674126 no 2103 0.335456039586155 738 1247028 SGTC_1956 st077085 54 µM -0.425053949356653 0.379543212221539 no 2104 0.335398673493737 750 24208685 SGTC_411 enrofloxacin 100 µM -0.42522681580074 0.379478089459388 no 2105 0.335335668840147 729 71188 A bacterial gyrase inhibitor. SGTC_2444 5485484 36.41 µM -0.42529523460044 0.379452315469518 no 2106 0.335310733511148 755 6790631 SGTC_1526 st051518 75 µM -0.425384385636188 0.379418732259833 no 2107 0.335278243377872 720 673993 SGTC_3312 9133330 71.43 µM -0.425773183184081 0.379272282798892 no 2108 0.335136564712066 752 17617324 SGTC_371 0195-0006 7.36 µM -0.426868677062388 0.378859733286894 no 2109 0.334737490566092 706 3928593 SGTC_660 4031-1742 102 µM -0.427421111612553 0.378651745536946 no 2110 0.334536316599099 716 6738706 SGTC_2727 riluzole 51.77 µM -0.429587929507639 0.377836293496134 no 2111 0.33374770951264 731 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_609 0986-0026 86.3 µM -0.429700071580317 0.377794105150424 no 2112 0.333706915674002 731 2848610 SGTC_1071 trifluoperazine 6.31 µM -0.429908857220238 0.377715562949145 no 2113 0.33363097111359 766 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_734 2023-0417 80 µM -0.430035120245587 0.377668067039904 no 2114 0.333585046980944 747 3935732 SGTC_2942 9052777 62.25 µM -0.430733424142616 0.37740542198852 no 2115 0.333331106343224 755 6469503 SGTC_1871 st057448 67.3 µM -0.430871537974016 0.377353481525258 no 2116 0.333280889811602 765 691747 SGTC_108 0509-0257 621.132 µM -0.431467526714358 0.377129373514814 no 2117 0.333064229737448 720 536624 SGTC_1884 5633444 25 µM -0.432072688675924 0.376901858463405 no 2118 0.332844291917742 718 5724239 SGTC_1628 st004252 77.7 µM -0.43275802205065 0.376644253993132 no 2119 0.332595286331875 694 692968 SGTC_3259 9138485 49.47 µM -0.433329885307689 0.376429342922647 no 2120 0.332387564918228 715 17646153 SGTC_1637 st007924 17.4 µM -0.433438955130906 0.376388357903522 no 2121 0.332347952657065 717 683336 SGTC_830 4076-0286 57.8 µM -0.434023137393432 0.37616886426199 no 2122 0.332135819713057 721 6866659 SGTC_2653 dihydrofissinolide 100 µM -0.434484224289888 0.375995649272179 no 2123 0.331968424116842 721 6857746 SGTC_1314 1222-0010 41.1 µM -0.434995376087918 0.37580365576337 no 2124 0.331782891867499 740 3526027 SGTC_780 0109-0199 192 µM -0.435027009344213 0.375791775019178 no 2125 0.331771411331501 758 610414 SGTC_2482 5981709 142.65 µM -0.435065138944265 0.37577745454995 no 2126 0.331757573312445 752 877755 SGTC_1379 2144-0755 36.5 µM -0.435286525576671 0.375694310968034 no 2127 0.331677232069206 747 5392327 SGTC_1003 4049-0218 100 µM -0.435366969600987 0.37566410097845 no 2128 0.331648040837783 733 295161 SGTC_1653 st012112 65 µM -0.435965029748513 0.375439529078282 no 2129 0.331431051036634 742 720429 SGTC_788 1182-0090 188 µM -0.436524759425776 0.375229388519146 no 2130 0.33122801964611 712 5715185 SGTC_387 norethindrone acetate 66.7 µM -0.43711573906617 0.375007555899094 no 2131 0.331013706754536 762 541197 SGTC_2391 6285546 200 µM -0.438199222746455 0.374600962300621 no 2132 0.330620935987863 720 846083 SGTC_2847 9005661 71.43 µM -0.438319297612478 0.374555910966712 no 2133 0.330577419438602 732 2991449 SGTC_169 k015-0017 16.025 µM -0.43872718049033 0.374402888669488 no 2134 0.33042961497406 786 1840002 SGTC_2745 rifampicin 24.3 µM -0.439545322104893 0.374096012396482 no 2135 0.330133224852369 720 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_664 1222-0054 14.9 µM -0.439815932582064 0.373994526812843 no 2136 0.330035213592314 733 6813991 SGTC_101 0490-5701 117.494 µM -0.440000417337324 0.373925345498823 no 2137 0.329968402528205 746 4661669 SGTC_2154 5570129 200 µM -0.440501795203052 0.373737350595786 no 2138 0.329786856180588 762 673366 SGTC_1985 st071382 65.5 µM -0.441314746487127 0.373432593057754 no 2139 0.329492575920308 756 6123237 SGTC_1231 0242-0792 125 µM -0.442091877051327 0.373141337905078 no 2140 0.329211361086241 755 3707635 SGTC_2830 7992007 71.43 µM -0.442355768934607 0.373042452247934 no 2141 0.329115890328791 742 1952075 SGTC_2481 5478948 45.16 µM -0.443550328069246 0.372594931341549 no 2142 0.328683862420483 719 77792 SGTC_3243 9134147 49.47 µM -0.443718387951903 0.3725319843979 no 2143 0.328623099721063 757 24282180 SGTC_3275 9138069 49.47 µM -0.444418497715564 0.372269794459537 no 2144 0.328370021102081 752 17617007 SGTC_3 0833-0587 95.581 µM -0.444526541500066 0.3722293375123 no 2145 0.328330971990974 727 5382644 SGTC_2747 doxorubicin 7.63 µM -0.444706881379702 0.37216181246587 no 2146 0.328265797852159 718 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_571 k831-0106 44.2 µM -0.447660584743898 0.371056411833972 no 2147 0.3271990859009 764 4783639 SGTC_448 monastrol 171 µM -0.447936898541207 0.370953057770375 no 2148 0.327099368841027 750 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2054 5233173 129 µM -0.449642832062862 0.370315166612296 no 2149 0.32648399930541 711 6889 SGTC_2153 5569715 200 µM -0.450178162080526 0.370115066746027 no 2150 0.326290990629317 733 2054701 SGTC_280 3448-3607 3.04 µM -0.4502137638864 0.370101760468884 no 2151 0.326278156350453 740 626179 SGTC_2896 9052656 71.43 µM -0.45110298706984 0.369769461228168 no 2152 0.325957662461535 755 6469436 SGTC_1713 st033146 12.748 µM -0.451218035723405 0.369726475092637 no 2153 0.325916206003345 770 674619 SGTC_2795 7780010 54.55 µM -0.451684728045541 0.369552119484331 no 2154 0.325748060871602 719 953673 SGTC_289 k017-0060 526 µM -0.452280723682551 0.369329495337467 no 2155 0.325533380428919 748 5512909 SGTC_2876 9059903 25.97 µM -0.453091652086455 0.369026657042756 no 2156 0.325241373123176 742 6916095 SGTC_2639 lactacystin 53 µM -0.453637480259289 0.368822865231931 no 2157 0.325044886183087 727 3870 A proteasome inhibitor. SGTC_2348 9022543 33.42 µM -0.454102953375548 0.368649104123213 no 2158 0.324877363843101 732 3162678 YDL140C RPO21 SGTC_1318 1280-3875 124 µM -0.455343453417442 0.368186156695482 no 2159 0.324431084691362 763 373245 SGTC_38 0929-0051 58.268 µM -0.456626316322306 0.367707600940449 no 2160 0.323969830257214 750 1379719 SGTC_3280 9140961 49.47 µM -0.457524989908585 0.367372484386723 no 2161 0.323646872269089 753 4901226 SGTC_863 0466-0191 129 µM -0.457574280463056 0.367354106793725 no 2162 0.323629162470089 760 765160 YPR165W RHO1 SGTC_702 1488-0190 94 µM -0.458679153452239 0.366942243454767 no 2163 0.323232293154094 747 949357 SGTC_855 0428-0020 25 µM -0.458765969437694 0.366909887554587 no 2164 0.323201117451098 722 6812414 SGTC_817 1391-0715 46 µM -0.460069040645015 0.366424352895526 no 2165 0.322733332626639 767 1353946 SGTC_1394 3474-0001 65.7 µM -0.46013920189748 0.366398216313599 no 2166 0.32270815364046 715 5017666 YIL048W NEO1 SGTC_641 4092-0595 30 µM -0.461323324254844 0.365957198731256 no 2167 0.32228332668395 738 786260 SGTC_821 1114-0266 29.2 µM -0.46279462713186 0.365409469609703 no 2168 0.321755791403506 740 3123235 SGTC_663 1486-0733 13.9 µM -0.46445759845997 0.36479071748127 no 2169 0.321159965790822 760 722445 YPR165W RHO1 SGTC_1426 4048-4480 71.7 µM -0.465444373896597 0.364423728076118 no 2170 0.320806631638044 744 14224343 SGTC_925 2064-1272 59.6 µM -0.46642708149759 0.364058374998935 no 2171 0.320454915296 743 6815817 SGTC_1248 0469-0687 58.6 µM -0.466748796232135 0.363938794047947 no 2172 0.32033980686684 756 4017482 SGTC_3229 9132204 49.47 µM -0.470573417126193 0.362518205336382 no 2173 0.318972697274596 747 17682924 SGTC_1488 4013-0813 75.9 µM -0.470720740000049 0.362463522519777 no 2174 0.318920085827115 732 2910057 SGTC_1313 1220-0047 237 µM -0.47107857594346 0.362330713845029 no 2175 0.318792311857388 741 3528706 SGTC_2012 4023501 200 µM -0.471489833277705 0.362178098603286 no 2176 0.318645489089831 798 3477460 SGTC_547 1120-0019 610 nM -0.471831719738626 0.362051243169405 no 2177 0.318523454049992 748 3676939 SGTC_2537 larixol 68.93 µM -0.471834031234985 0.362050385550628 no 2178 0.318522629037355 736 6708759 SGTC_598 3937-0236 20.2 µM -0.472218904066872 0.361907598462276 no 2179 0.318385273882607 764 1379313 SGTC_1563 conessine 56.1 µM -0.474411866763902 0.361094380764338 no 2180 0.317603116229608 766 441082 An anti-amoebic, histamine inhibitor. SGTC_1222 0366-0074 1.18 µM -0.475978968756083 0.360513635505325 no 2181 0.317044680590612 759 286520 SGTC_1405 3909-7894 12 µM -0.476219846599137 0.360424398154801 no 2182 0.316958880842424 756 7104060 SGTC_462 ag-879 158 µM -0.47753073269039 0.35993889117348 no 2183 0.316492120946663 765 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2744 captopril 92.04 µM -0.478014211987228 0.359759884097402 no 2184 0.316320044869824 738 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2827 7993847 71.43 µM -0.478931637836844 0.359420293917495 no 2185 0.315993631354778 747 2985692 SGTC_2716 st080858 38.6235 µM -0.479162729676349 0.359334771504741 no 2186 0.315911433141293 736 5296050 SGTC_2953 9074162 66.49 µM -0.479257039539265 0.35929987135768 no 2187 0.315877890208817 737 16451992 SGTC_1792 st045773 43.6 µM -0.479754036247086 0.359115973002752 no 2188 0.315701149792714 725 2919270 SGTC_3121 9125696 49.47 µM -0.479846050270331 0.359081929621394 no 2189 0.315668432675022 768 1235365 SGTC_431 k089-0097 107 µM -0.4799258050962 0.359052422807575 no 2190 0.315640075687674 759 5499420 SGTC_409 arachidonic acid 100 µM -0.481022771797158 0.358646664512437 no 2191 0.315250157180052 737 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2052 5265182 7.135 µM -0.481975007037635 0.35829457040307 no 2192 0.314911850455481 758 1239884 SGTC_955 1216-0110 33 µM -0.48255150765494 0.35808146471289 no 2193 0.314707108805173 733 3619719 SGTC_2409 alverine citrate 63.97 µM -0.483223925001092 0.357832958889862 no 2194 0.314468374705807 706 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1819 st053448 58.6 µM -0.48350237053584 0.357730071179829 no 2195 0.314369538502109 783 2857616 SGTC_544 k015-0020 52.4 µM -0.483681886558257 0.357663744145024 no 2196 0.314305825079416 757 3008304 SGTC_1656 st012921 11 µM -0.484869033852942 0.357225228847556 no 2197 0.313884624760275 760 6732821 SGTC_337 1315-0038 354 µM -0.485944239859789 0.356828225720339 no 2198 0.313503350414024 762 1626437 SGTC_1709 st033179 39.1045 µM -0.486485129125689 0.356628569333476 no 2199 0.313311623186565 741 573381 SGTC_721 1187-1332 279 µM -0.487096469284039 0.35640295496422 no 2200 0.313094984193434 758 25730 SGTC_1453 4237-0541 195 µM -0.487365652520712 0.356303629134775 no 2201 0.312999614892258 760 739892 SGTC_193 1273-0060 1.558 µM -0.487515832533051 0.35624821849979 no 2202 0.312946412844666 764 2847393 YHR072W ERG7 SGTC_2490 carminic acid 95.39 µM -0.489932527365373 0.355356969407441 no 2203 0.312090822464812 750 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2999 9069765 71.4286 µM -0.491216999998621 0.354883592158683 no 2204 0.311636488230473 754 2097066 SGTC_633 0437-0093 97.7 µM -0.491403029997504 0.354815051544365 no 2205 0.311570710808699 758 2831118 SGTC_2873 9040596 71.43 µM -0.492640867213568 0.354359104411007 no 2206 0.311133183302732 806 6463863 SGTC_1284 0929-0043 16 µM -0.492909959871405 0.354260013937285 no 2207 0.311038104748779 751 1239883 SGTC_3277 9138724 49.47 µM -0.493037189131595 0.354213166567019 no 2208 0.310993155203213 758 15943418 SGTC_2731 amoxapine 43.43 µM -0.493419029568922 0.354072581495196 no 2209 0.310858269564838 775 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3199 9111318 49.47 µM -0.493458327083058 0.354058114161709 no 2210 0.310844389108034 746 8548020 SGTC_207 4185-0010 4.486 µM -0.493567924718859 0.354017767034505 no 2211 0.310805679042141 744 3761753 SGTC_2453 5731132 22.18 µM -0.493591946662609 0.354008923847216 no 2212 0.310797194731713 788 1362040 SGTC_62 0180-0423 3.232 µM -0.496037489074507 0.353109060264111 no 2213 0.30993398067454 782 30102 YGL099W LSG1 SGTC_1040 k898-0338 155 µM -0.496304833615175 0.353010737650781 no 2214 0.309839678259934 783 20969351 SGTC_63 0099-0242 26.702 µM -0.497089428226028 0.352722240125252 no 2215 0.30956299466614 770 3898502 YLR359W ADE13 SGTC_1552 6-methylflavone 10.6 µM -0.497231749498143 0.352669917283113 no 2216 0.309512817296437 774 689013 SGTC_1396 3511-0007 98.6 µM -0.498276045850709 0.352286078582498 no 2217 0.309144744567339 757 X1396 SGTC_602 3130-1533 38.1 µM -0.49886764156028 0.352068700000053 no 2218 0.308936315663828 767 720941 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.500623507285229 0.351423801666467 no 2219 0.308318057657884 759 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2923 7992654 58.14 µM -0.500910022695443 0.351318610157584 no 2220 0.308217224211465 731 2985126 SGTC_2251 lansoprazole 556 µM -0.50091733112316 0.351315927084196 no 2221 0.308214652343743 774 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_903 1134-0042 114 µM -0.501591487313728 0.351068462431376 no 2222 0.307977454332674 741 701009 SGTC_1127 asiatic acid 681.4 nM -0.501625350438346 0.351056033851454 no 2223 0.307965541900006 758 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_33 0986-0033 35.816 µM -0.502330512528088 0.350797258652575 no 2224 0.307717524669806 738 2848082 SGTC_363 0455-0021 3.06 µM -0.503301491624196 0.350441049146132 no 2225 0.307376158944318 758 4597466 SGTC_1373 2887-0003 58.5 µM -0.504836797886214 0.349878081253677 no 2226 0.306836733974465 740 776948 SGTC_2979 9012552 45.46 µM -0.505318436843149 0.349701541231761 no 2227 0.306667597734942 769 17100905 SGTC_1864 st057645 30.4 µM -0.505396375953053 0.349672976471321 no 2228 0.30664023187382 784 688666 SGTC_396 dithiazanine 1.25 µM -0.506341672039168 0.349326592324261 no 2229 0.306308406814119 750 10578 An antihelmenthic. SGTC_572 0960-0087 17.7 µM -0.507128462940941 0.349038384762602 no 2230 0.306032342528866 764 6796365 SGTC_3250 9135583 49.47 µM -0.508756015182539 0.348442476314 no 2231 0.305461626822355 754 7699353 SGTC_2575 plumbagin 510 nM -0.510003122936255 0.347986115878072 no 2232 0.305024636959183 778 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1726 st035556 14.5795 µM -0.510092470533676 0.347953428901966 no 2233 0.304993339984393 757 5919439 SGTC_843 0310-0051 143 µM -0.510687620137125 0.347735727869077 no 2234 0.304784905396476 785 2065037 SGTC_1423 4048-0112 5.59 µM -0.510805162794447 0.347692737625292 no 2235 0.304743746840099 760 X1423 SGTC_535 2293-4129 48.2 µM -0.51089321742506 0.347660533663666 no 2236 0.304712915384844 796 396118 YIL048W NEO1 SGTC_887 0885-0007 9.62 µM -0.511342175240494 0.347496354734099 no 2237 0.304555738827604 763 5719458 SGTC_3026 9090633 49.47 µM -0.511690477765619 0.347369004037436 no 2238 0.304433825737567 763 25236842 SGTC_561 1550-0330 72.9 µM -0.513163369235181 0.34683065778025 no 2239 0.303918523571898 765 6812934 SGTC_1539 benzyladenosine 56 µM -0.513412141774355 0.34673976115111 no 2240 0.303831527037218 745 92208 A nucleotide analog. SGTC_2265 7929201 200 µM -0.51410885059111 0.346485244311274 no 2241 0.303587944929143 790 1265108 SGTC_1929 genistein trimethyl ether 50.5 µM -0.514119836012978 0.34648123174764 no 2242 0.303584104923651 766 136420 SGTC_1868 st057644 42.7 µM -0.515048034536601 0.346142257812176 no 2243 0.303259727163374 758 688665 SGTC_1579 chlormadinone acetate 49.4 µM -0.515241135425815 0.346071753710496 no 2244 0.30319226362442 771 45114258 A steroidal progestin. SGTC_2415 st077333 57.7 µM -0.515867680884612 0.345843029088409 no 2245 0.302973414051418 792 2766255 SGTC_3030 9087619 49.47 µM -0.51659782275452 0.345576556869178 no 2246 0.302718467943563 752 25236973 SGTC_217 ketoconazole 989 nM -0.51710614793317 0.345391083922225 no 2247 0.302541031083128 755 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1610 st001799 48.1 µM -0.517851310686027 0.345119262990209 no 2248 0.302281007589526 758 621897 SGTC_1996 st072960 66.8 µM -0.519947151722036 0.344355169526309 no 2249 0.301550205029206 731 1719405 SGTC_2619 obliquin 87.91 µM -0.521020215758684 0.343964201579555 no 2250 0.301176344347147 776 6708593 A bioactive alkalod. YER133W GLC7 SGTC_646 4092-0839 27.3 µM -0.522655354024198 0.343368764207226 no 2251 0.300607056211963 771 877796 SGTC_1703 st026983 48.3 µM -0.522838683747798 0.343302028687438 no 2252 0.300543258613831 767 1104023 SGTC_1335 1486-0900 202 µM -0.523248663105506 0.34315280605584 no 2253 0.3004006104892 751 X1335 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.524232499516492 0.342794813043089 no 2254 0.300058419519038 763 66535 A nucleotide analog. SGTC_2281 7943571 200 µM -0.525231716593301 0.342431367832989 no 2255 0.299711059558271 781 1244024 SGTC_933 2914-0560 114 µM -0.526321781861849 0.342035044766824 no 2256 0.299332325718444 749 463887 SGTC_3254 9136651 49.47 µM -0.528427774340576 0.341269846606224 no 2257 0.298601232205365 799 16454030 SGTC_2336 9001819 198.65 µM -0.529289300183394 0.340957004792054 no 2258 0.298302388467397 786 2989602 SGTC_2974 9094440 9.66 µM -0.530108621587884 0.340659589889855 no 2259 0.298018310880476 746 25236134 SGTC_2186 6124449 200 µM -0.533206802162045 0.339535842314824 no 2260 0.296945216685632 746 3834182 YLR033W RSC58 SGTC_2455 5377712 9.75 µM -0.534013106147595 0.339243619410166 no 2261 0.296666233230204 744 2243908 SGTC_970 1315-0089 19.5 µM -0.535808264743817 0.33859336049238 no 2262 0.296045534826469 769 6811083 YLR033W RSC58 SGTC_833 3852-0053 558 µM -0.536052363121511 0.338504978022421 no 2263 0.295961180833528 792 3123681 SGTC_1213 1315-0166 115 µM -0.53682525570294 0.338225189887598 no 2264 0.295694162258158 741 768401 SGTC_312 4092-0653 6.84 µM -0.537671550287867 0.337918932567801 no 2265 0.295401911840216 785 1148278 SGTC_3115 9123671 49.47 µM -0.537854080987723 0.337852892362239 no 2266 0.295338896044531 784 3286988 SGTC_1259 0671-0132 43 µM -0.5379667525284 0.33781212992066 no 2267 0.295300001090549 754 X1259 SGTC_524 r073-0010 27.8 µM -0.538918972015397 0.337467710851827 no 2268 0.294971382873056 793 2772106 SGTC_655 k060-0012 42 µM -0.539287202969415 0.337334557701982 no 2269 0.294844348751116 774 5994525 SGTC_1034 k072-0165 12.7 µM -0.539363347953743 0.337307026043649 no 2270 0.294818083027575 790 5835461 SGTC_2176 5809774 33.9695 µM -0.540024532876508 0.33706799877427 no 2271 0.294590056894286 765 2870539 SGTC_408 cantharidin 100 µM -0.540826132014586 0.336778298078584 no 2272 0.294313714589236 756 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3118 9124250 49.47 µM -0.542422794538806 0.336201547353482 no 2273 0.293763640119037 780 1504786 SGTC_3088 9117578 49.47 µM -0.544534050005272 0.335439505748662 no 2274 0.293037011871382 799 678341 SGTC_1400 3771-8998 51.5 µM -0.544588236716246 0.33541995635865 no 2275 0.293018373475632 754 670767 SGTC_2686 alizarin 95.37 µM -0.547255745342059 0.334458128931265 no 2276 0.292101521473804 738 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_230 MPP+ 141.667 µM -0.547709283174949 0.33429470394789 no 2277 0.291945768445725 792 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3143 9086658 49.47 µM -0.550207555519248 0.333395055764126 no 2278 0.29108851096159 761 25236626 SGTC_323 4013-0906 34.3 µM -0.550978881480155 0.333117488217104 no 2279 0.290824075805575 761 2910086 SGTC_3324 9138759 60.749 µM -0.551979225082612 0.332757643055188 no 2280 0.290481293459192 777 45595710 SGTC_1178 0988-0033 191 µM -0.552618118508847 0.332527899882208 no 2281 0.290262466297565 767 5392207 SGTC_1810 st050138 53 µM -0.553159052193108 0.332333431750373 no 2282 0.290077251678482 814 3444541 SGTC_2402 5553605 200 µM -0.553709494901492 0.33213559140725 no 2283 0.289888838070402 770 6758546 SGTC_1865 st057639 52.2 µM -0.554469533795721 0.331862494813531 no 2284 0.289628775186289 779 688818 SGTC_415 dibenzyl ketone 100 µM -0.554730082765815 0.331768895106379 no 2285 0.289539648230779 789 7593 SGTC_1747 st037496 66.6 µM -0.555210664160409 0.331596278420671 no 2286 0.289375287759379 801 723305 SGTC_2471 5466956 24.79 µM -0.555244019185115 0.331584299188128 no 2287 0.2893638818545 784 724419 SGTC_229 benomyl 22.8748 µM -0.555258674547928 0.331579035867716 no 2288 0.289358870452238 772 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1470 k295-0292 231 µM -0.556035838549219 0.331299973198978 no 2289 0.289093177610698 792 5045612 SGTC_924 2046-0044 21.3 µM -0.558633740643037 0.330367803638422 no 2290 0.288205854002389 780 3623589 SGTC_1959 st077091 55.8 µM -0.559122742893609 0.330192459102409 no 2291 0.288038977153723 796 821356 YKL052C ASK1 SGTC_1947 st076332 61.6 µM -0.560476315801091 0.329707294712249 no 2292 0.287577295020322 792 24208416 SGTC_618 k072-0232 33.2 µM -0.560979233696987 0.329527105575712 no 2293 0.287405846925136 790 5872756 YGL099W LSG1 SGTC_2175 5807670 165.306 µM -0.560979660248168 0.329526952764596 no 2294 0.28740570153149 772 241186 SGTC_2628 lathosterol 100 µM -0.561286996268953 0.329416857644417 no 2295 0.287300952445061 777 6710616 SGTC_3180 9109287 49.47 µM -0.561678525500938 0.32927662391829 no 2296 0.287167534026208 768 18891271 SGTC_3219 9131112 49.47 µM -0.561977121184825 0.329169692269644 no 2297 0.287065803578757 779 17612988 YMR079W SEC14 SGTC_818 4072-2707 53.5 µM -0.563487180955431 0.328629131126707 no 2298 0.286551593355165 776 882871 SGTC_867 0518-0118 155 µM -0.564808143953922 0.328156555419556 no 2299 0.286102133554537 790 6848158 SGTC_523 1934-0222 13.7 µM -0.565966711758068 0.327742302990329 no 2300 0.285708204894642 809 1361595 SGTC_2518 prenyletin 46.28 µM -0.568704418909953 0.326764263122927 no 2301 0.284778374241327 773 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2972 9093619 59.92 µM -0.568845214951987 0.32671399614082 no 2302 0.284730593559935 753 25236256 SGTC_150 3970-0969 77.2 µM -0.569408554024234 0.326512904384604 no 2303 0.284539456557883 801 6615640 SGTC_156 3474-0145 5.642 µM -0.570899133035352 0.325981064620023 no 2304 0.284034009337047 780 2265471 SGTC_3055 9094636 49.47 µM -0.571745164698844 0.325679357189941 no 2305 0.283747315827539 778 25236176 SGTC_3206 9114350 49.47 µM -0.5724708381853 0.32542066220536 no 2306 0.283501518373342 783 17087243 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.572638908422938 0.325360758917438 no 2307 0.283444604797852 795 4620898 SGTC_2316 5844804 197.44 µM -0.573015066180761 0.325226705805173 no 2308 0.283317246455289 781 776813 SGTC_928 2764-0428 58.7 µM -0.574467064301853 0.324709462651043 no 2309 0.282825890952405 800 662578 SGTC_1842 st055362 61.2 µM -0.574630334189564 0.324651322371327 no 2310 0.282770666107188 757 676032 SGTC_813 k007-0158 173 µM -0.574774733237538 0.324599905543091 no 2311 0.282721828502765 800 6523916 SGTC_406 estrone 100 µM -0.575152985918143 0.324465235232756 no 2312 0.282593917826019 796 5870 A steroid. SGTC_763 3453-1109 128 µM -0.576322554824431 0.324048975762265 no 2313 0.282198590165118 794 1560353 SGTC_2661 dactinomycin 12.96 µM -0.576465429091258 0.323998140663318 no 2314 0.282150315280424 791 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3281 9140613 49.47 µM -0.577159642348811 0.323751184203937 no 2315 0.281915808546503 766 16013766 SGTC_422 cantharidin 155 µM -0.578660094378695 0.323217684965341 no 2316 0.281409273663861 792 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1089 terbinafine 2.25 µM -0.578675567869046 0.323212185117585 no 2317 0.281404052285102 790 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_275 trichlorophene 5.69 µM -0.579338547471419 0.322976574084645 no 2318 0.281180380195803 781 62616 SGTC_3057 9095946 49.47 µM -0.57967035363202 0.322858682799848 no 2319 0.281068469666735 806 24540043 SGTC_1934 st074720 32.6 µM -0.580817068578462 0.322451390164451 no 2320 0.280681875061001 789 17250992 SGTC_545 4218-0007 221 µM -0.580823759721924 0.322449014214619 no 2321 0.28067962001568 804 2840508 SGTC_1623 st003709 20.3 µM -0.581145692291566 0.322334708147502 no 2322 0.280571132842053 775 16192618 SGTC_2607 solasodine 47.35 µM -0.581812046449593 0.322098164388434 no 2323 0.280346644469143 783 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_966 1300-0360 30.2 µM -0.584652114384114 0.321090800131549 no 2324 0.279390829194809 805 70588 SGTC_2002 4023503 131 µM -0.586156413276062 0.3205577617652 no 2325 0.278885204570455 827 4736863 YCR052W RSC6 SGTC_1718 roemerine 11.9335 µM -0.586432297490737 0.320460044123153 no 2326 0.278792522763621 786 235224 An aporphine alkaloid with mutagenic activity. SGTC_2981 9013952 38.96 µM -0.586546082994663 0.320419745147699 no 2327 0.278754301507154 768 2996344 SGTC_952 1185-0122 232 µM -0.587868377166123 0.3199515886694 no 2328 0.27831032183888 792 678600 SGTC_3046 9092212 49.47 µM -0.58812502674439 0.319860755419115 no 2329 0.278224187939926 796 25236637 SGTC_2288 7946289 167.31 µM -0.589038669696529 0.319537487195342 no 2330 0.277917666715715 805 1246052 SGTC_2314 7727897 200 µM -0.589276131543698 0.319453490080435 no 2331 0.277838026816716 775 900724 SGTC_2129 girgensonine 121.053 µM -0.590635840452138 0.318972700250491 no 2332 0.277382222630191 797 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1153 4055-0057 267 µM -0.590758609603341 0.318929304343876 no 2333 0.277341085725909 804 882706 SGTC_3187 9109394 49.47 µM -0.591453034360537 0.318683888835309 no 2334 0.277108457351025 779 17098090 SGTC_482 fipronil 114 µM -0.591681489703916 0.318603168184377 no 2335 0.277031946979275 790 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2517 totarol 10 µM -0.592591457286471 0.318281732706715 no 2336 0.276727298794562 784 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_880 0833-0487 87.2 µM -0.59314402263718 0.31808661214351 no 2337 0.27654238549056 803 76075 SGTC_264 promethazine 12.5 mM -0.594649118382071 0.31755539243803 no 2338 0.276039019948221 821 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_412 gemfibrozil 100 µM -0.596099520130548 0.317043832026469 no 2339 0.275554372369423 779 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1750 st081859 2.357 µM -0.597692798583812 0.316482281436478 no 2340 0.275022465732813 802 5291695 SGTC_2568 diosmetin 100 µM -0.597706614040145 0.316477414029584 no 2341 0.275017855736824 822 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1648 st011736 69.8 µM -0.599639907054401 0.315796597661854 no 2342 0.274373122539678 794 2855514 SGTC_1545 lovastatin 49.4 µM -0.599695022141653 0.315777197822373 no 2343 0.274354753172919 793 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_196 k015-0023 18.111 µM -0.601323162882035 0.31520434123274 no 2344 0.273812382425311 786 5211998 SGTC_2027 5150920 200 µM -0.601359550879235 0.315191543290017 no 2345 0.273800266815042 783 786715 SGTC_1515 3460-0031 42.1 µM -0.601467248548041 0.315153666478754 no 2346 0.273764409759088 799 2876596 SGTC_2434 5670830 169.91 µM -0.602011717573803 0.314962208794087 no 2347 0.273583168818181 818 1549830 SGTC_645 0845-0943 5.41 µM -0.602949062399016 0.314632716309735 no 2348 0.273271287926438 787 1885106 SGTC_2774 tamoxifen 10.92 µM -0.603409770467511 0.314470823736387 no 2349 0.273118062020426 805 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1163 k060-0048 49.9 µM -0.603676838160518 0.314376992619342 no 2350 0.273029258049827 795 6809982 SGTC_2406 ethylparaben 405.7 µM -0.605972106873777 0.313571071651903 no 2351 0.272266637794208 793 8434 A possible steroid mimic. SGTC_1688 st021091 57.6 µM -0.606526693446567 0.313376476926806 no 2352 0.272082531143453 820 3656366 SGTC_3135 9127742 49.47 µM -0.606570511897949 0.313361104012304 no 2353 0.272067987327888 807 3643468 SGTC_2295 7971645 200 µM -0.60702318777224 0.313202309816803 no 2354 0.271917761960919 790 2978226 YKL099C UTP11 SGTC_1066 ketoconazole 628 nM -0.607145116941913 0.313159544195707 no 2355 0.27187730550707 813 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2140 5586273 200 µM -0.608438919884541 0.312705908699406 no 2356 0.271448202486192 804 854421 SGTC_689 0833-0039 98 µM -0.608813217819406 0.312574724539895 no 2357 0.271324125687914 845 5374726 SGTC_1901 st060216 58.6 µM -0.609352328505207 0.312385818440448 no 2358 0.271145464456506 798 688792 SGTC_1684 st024538 14.6195 µM -0.610053695559189 0.312140130983024 no 2359 0.27091311931681 796 6732859 SGTC_626 0214-0009 33 µM -0.611921391376707 0.311486288522874 no 2360 0.270294883940036 810 3437874 SGTC_848 0368-0089 85.6 µM -0.616489815064373 0.309889482767613 no 2361 0.268785645947078 813 762535 SGTC_1010 4112-3296 15.2 µM -0.616694504743333 0.309818020953884 no 2362 0.268718123263735 809 704384 SGTC_284 0988-0104 32.6 µM -0.617959436926984 0.30937656391904 no 2363 0.268301038729586 822 4666532 SGTC_1218 1348-1416 30.7 µM -0.619088184378932 0.30898286702346 no 2364 0.267929133363687 806 6787668 SGTC_1022 4477-0945 21.3 µM -0.619294521937532 0.308910922048884 no 2365 0.267861176308693 792 4648966 SGTC_1497 4476-2978 41.3 µM -0.62147130634971 0.308152376401023 no 2366 0.267144784030271 804 1528379 SGTC_144 4161-2749 112.381 µM -0.621977539338988 0.307976086238181 no 2367 0.266978318569065 803 797501 YMR168C CEP3 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.624204381734689 0.307201138964692 no 2368 0.266246684807653 824 442882 SGTC_1321 1326-2144 215 µM -0.624375094900342 0.307141765771961 no 2369 0.266190638549867 818 3513030 SGTC_1857 st056007 79.3 µM -0.625018034623613 0.30691819991081 no 2370 0.265979610822503 792 619834 SGTC_2203 7227154 166.4 µM -0.62667504744465 0.306342347089733 no 2371 0.265436131747353 796 896304 SGTC_3171 9103192 49.47 µM -0.62721864721672 0.3061535368195 no 2372 0.265257960785782 810 13018434 SGTC_794 k038-0031 316 µM -0.628135299198785 0.305835269726591 no 2373 0.264957655331822 815 6624242 SGTC_3321 9137793 26.8275 µM -0.629645074129519 0.305311386370881 no 2374 0.264463413051899 807 4904192 SGTC_1354 1498-1681 81 µM -0.629783718206854 0.305263297624063 no 2375 0.264418049842519 798 5754243 SGTC_810 3825-7150 143 µM -0.631930386486167 0.304519154282448 no 2376 0.263716183266986 779 22330411 YGL099W LSG1 SGTC_2337 9009472 200 µM -0.632174064939414 0.30443473409148 no 2377 0.263636571174343 809 5742383 SGTC_1334 1486-0610 236 µM -0.632912040743148 0.304179132631008 no 2378 0.263395542204248 791 3742339 SGTC_2689 tacrolimus 100 µM -0.633630748277523 0.303930296766016 no 2379 0.263160914591167 806 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2902 5787006 60.46 µM -0.63488961338538 0.303494662732556 no 2380 0.262750205841569 807 591003 SGTC_1932 st074806 40.9 µM -0.635149338439374 0.303404818818929 no 2381 0.262665510535266 821 17251235 SGTC_2109 5483026 200 µM -0.636867845530915 0.302810653717613 no 2382 0.262105464407219 845 759335 SGTC_3062 9077494 49.47 µM -0.637321085836662 0.30265403505776 no 2383 0.261957859487403 769 16459633 SGTC_889 0919-1524 82.7 µM -0.637478405631745 0.302599681178306 no 2384 0.261906635757811 808 3905452 SGTC_2102 5377816 72.7585 µM -0.637500355143632 0.302592097985028 no 2385 0.261899489348663 809 1379702 SGTC_1993 st073995 70.8 µM -0.638312786485235 0.302311476334435 no 2386 0.261635045096575 819 3098394 SGTC_279 1273-0055 2.93 µM -0.638486102187628 0.302251626526503 no 2387 0.261578649034113 830 2847562 SGTC_1707 st032323 6.317 µM -0.638695287581566 0.302179397189999 no 2388 0.261510589464935 807 3132057 YMR211W DML1 SGTC_1559 coumarin 343 70.1 µM -0.638994400378028 0.302076130406164 no 2389 0.261413287338323 822 108770 A hepatotoxic, DNA x-linker. SGTC_917 harmaline 728.087 nM -0.639145708230196 0.302023898372053 no 2390 0.26136407360503 791 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_381 3461-2219 42.7 µM -0.639245141448822 0.301989575863387 no 2391 0.261331734980547 831 2883159 SGTC_223 busulfan 5 mM -0.639594622201537 0.301868955471617 no 2392 0.261218089809423 807 2478 A DNA alkylator. SGTC_2464 5717415 7.67 µM -0.641799096236495 0.30110859901863 no 2393 0.260501818269155 793 5285744 SGTC_2358 9037157 4 µM -0.642914461730149 0.300724221672216 no 2394 0.260139802508798 813 2388925 SGTC_2982 9019404 25.97 µM -0.642947661736585 0.300712783677584 no 2395 0.260129030711455 781 22333232 SGTC_914 3820-6779 408 µM -0.642974445196468 0.300703556440818 no 2396 0.260120340940887 791 2893481 SGTC_2350 9023895 38.85 µM -0.64607839527704 0.299635073549881 no 2397 0.259114293127435 815 2997209 SGTC_305 1682-2595 20.8 µM -0.646602302343316 0.299454897109514 no 2398 0.258944683777521 815 226033 SGTC_85 0868-0259 160.055 µM -0.648319039720579 0.298864839883091 no 2399 0.258389310960845 802 83173 SGTC_1797 st048695 56.8 µM -0.649407052304789 0.2984911544134 no 2400 0.258037653420347 838 592262 YIL048W NEO1 SGTC_2355 9061122 103.12 µM -0.649874558947865 0.298330651334844 no 2401 0.257886626450099 829 5302957 SGTC_53 0973-0023 39.979 µM -0.650398032506523 0.29815098049045 no 2402 0.257717573939721 827 674768 SGTC_913 3487-1245 167 µM -0.65113410006298 0.297898424826837 no 2403 0.257479962883233 796 4016153 SGTC_1336 1486-0901 104 µM -0.651740509805059 0.297690429987597 no 2404 0.257284292392161 808 5006114 SGTC_206 4546-0025 72.014 µM -0.654971799538367 0.296583236330285 no 2405 0.256242955416761 841 6620745 YIL048W NEO1 SGTC_1300 1094-0077 113 µM -0.655503021522983 0.296401395102202 no 2406 0.256071970830774 822 5532636 SGTC_424 splitomicin 100 mM -0.655764760342187 0.296311818759882 no 2407 0.255987746764851 831 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2388 9080168 200 µM -0.656060047014774 0.296210776052417 no 2408 0.255892744799429 836 15943073 SGTC_2488 5268135 45.7 µM -0.656933751068132 0.295911900128882 no 2409 0.255611757613655 828 1270356 YLR208W SEC13 SGTC_1494 4358-1428 177 µM -0.657442792309212 0.295737831612521 no 2410 0.255448121967668 816 1564571 SGTC_2384 9036245 200 µM -0.657787422049756 0.295620010926589 no 2411 0.255337368881535 799 6462766 SGTC_2419 paclitaxel 166.5 µM -0.660570055504374 0.294669486408677 no 2412 0.254444038908185 826 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2810 7959871 45.46 µM -0.660931684080817 0.294546060660203 no 2413 0.254328062909603 818 2974535 SGTC_379 3970-0972 5.9 µM -0.661297853214495 0.294421109507861 no 2414 0.254210658973335 827 2898042 YBL034C STU1 SGTC_17 0960-0276 49.807 µM -0.661480405590212 0.294358824678088 no 2415 0.254152138258116 819 6821114 SGTC_1267 0828-0272 9.49 µM -0.662237083541762 0.294100719518567 no 2416 0.253909645780405 820 745334 SGTC_3011 9081274 71.4286 µM -0.662940545172487 0.293860860471225 no 2417 0.253684316495393 820 6625322 SGTC_3072 9116419 49.47 µM -0.664140540553062 0.293451907465117 no 2418 0.253300182517135 812 17170162 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.665444983512716 0.293007658482598 no 2419 0.252882960666268 806 77254 SGTC_1649 st011737 51.3 µM -0.665683026815549 0.292926622693287 no 2420 0.252806862334368 799 1761035 SGTC_691 1548-0686 185 µM -0.665778689559896 0.292894059674582 no 2421 0.252776284003846 824 46495133 SGTC_3113 9123498 49.47 µM -0.667209863491352 0.292407097450528 no 2422 0.252319045828483 843 8897275 SGTC_2000 st075254 36.4 µM -0.667357543151649 0.292356870331804 no 2423 0.252271889266758 803 17234175 SGTC_2163 5671233 125 µM -0.667941398298923 0.292158335485044 no 2424 0.252085500158656 815 701023 SGTC_1197 1601-0112 267 µM -0.668556054240347 0.291949394910955 no 2425 0.251889356774337 830 7350313 SGTC_1708 st033234 31.827 µM -0.669801119827568 0.291526371960706 no 2426 0.251492289815523 802 674664 SGTC_2549 cedrol 20.94 µM -0.669956393801369 0.291473636195535 no 2427 0.251442794213316 822 6708665 A sedative which affects the nervous system. SGTC_2161 5662504 8.5105 µM -0.670160329783139 0.291404380092847 no 2428 0.25137779478391 813 2859334 SGTC_162 k030-0015 37.8 µM -0.670573398214562 0.291264126710208 no 2429 0.251246166901422 845 1809920 YMR134W ERG29 SGTC_15 0266-0086 27.098 µM -0.670721675184068 0.29121378838889 no 2430 0.251198926034269 841 1712902 YIL048W NEO1 SGTC_3343 9148379 18.9835 µM -0.671080906171001 0.291091850454155 no 2431 0.251084494946056 818 1955036 SGTC_1651 st011928 86.1 µM -0.67256912049491 0.290586942843129 no 2432 0.250610726244214 829 720198 SGTC_1441 4106-0040 13 µM -0.672786352513434 0.290513276654778 no 2433 0.250541610690923 821 2904180 SGTC_2425 5628681 7.85 µM -0.672965880511141 0.290452402984626 no 2434 0.250484498847888 841 5714958 SGTC_2733 amorolfine 100 µM -0.67314767770245 0.290390765970045 no 2435 0.250426672154964 849 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_761 k216-0224 480 µM -0.675107123373495 0.289726819220994 no 2436 0.249803854121647 862 1340404 SGTC_5 0352-0601 109.883 µM -0.675548100510353 0.28957749494557 no 2437 0.249663801138663 822 762456 SGTC_3306 9127676 59.7925 µM -0.676392744902711 0.289291581250216 no 2438 0.249395661161823 818 41905287 SGTC_2017 5132927 60.65 µM -0.678701457541623 0.288510755422932 no 2439 0.248663521230671 817 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_950 1165-0508 94.1 µM -0.679122054471125 0.288368613055352 no 2440 0.248530264731042 835 6148369 SGTC_2013 4024628 200 µM -0.680229095470965 0.287994642146569 no 2441 0.248179706102155 843 5230760 SGTC_836 0330-0104 1.35 µM -0.682268799115112 0.287306207448179 no 2442 0.247534499155017 819 46494820 SGTC_495 decylubiquinone 155 µM -0.682314530834375 0.287290781143553 no 2443 0.24752004339949 842 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1754 st042065 16.137 µM -0.683138940296919 0.287012757122682 no 2444 0.247259525679729 827 1126236 YIL048W NEO1 SGTC_3082 9117008 49.47 µM -0.684744463744155 0.286471676108757 no 2445 0.246752592904535 835 41448529 SGTC_14 0354-0009 295 µM -0.685240723616753 0.286304528449682 no 2446 0.246596014987133 843 1713507 SGTC_2255 7941087 197.44 µM -0.686143889911568 0.286000447566002 no 2447 0.246311188216358 821 935561 SGTC_1185 1319-0113 81.3 µM -0.686660582272814 0.285826554999155 no 2448 0.246148321024062 836 4672763 SGTC_192 3455-0609 60.9 µM -0.686739811666608 0.285799894831187 no 2449 0.246123352144045 817 3769639 SGTC_1600 coumarin 106 71.1 µM -0.687251441910932 0.285627763114357 no 2450 0.245962146289084 850 100336 A hepatotoxic, DNA x-linker. SGTC_886 0866-0150 153 µM -0.688605077693346 0.285172587045393 no 2451 0.245535912411189 832 271463 SGTC_1235 benzylparaben 21.5 µM -0.690893898766831 0.284403731240641 no 2452 0.244816110304061 847 7180 SGTC_2269 7935389 174.42 µM -0.691132936419606 0.284323491388395 no 2453 0.244741001876043 823 97605 SGTC_1389 3405-0187 19 µM -0.691175637397672 0.284309158718052 no 2454 0.244727586035108 822 799890 SGTC_429 1112-0049 25.5 µM -0.693705819135358 0.28346051513075 no 2455 0.243933357967274 830 2836170 SGTC_936 3005-4620 401 µM -0.693992514993808 0.283364431638512 no 2456 0.243843451483684 836 777207 SGTC_1883 5-benzylidenerhodanine 20 µM -0.694226247374452 0.283286109927844 no 2457 0.243770167334663 817 1273210 SGTC_1051 3253-3903 78 µM -0.694638290149524 0.283148063226982 no 2458 0.24364100493275 832 5509239 SGTC_2196 6573537 42.6665 µM -0.696765005048321 0.282436063586077 no 2459 0.242974934949207 855 2903087 SGTC_2994 9053520 71.4286 µM -0.697492059993185 0.282192851626168 no 2460 0.24274745333641 831 4647384 SGTC_715 0868-0130 184 µM -0.698434091816341 0.281877876332439 no 2461 0.242452881094467 843 2876258 SGTC_2001 4023502 57.655 µM -0.699110472291801 0.281651828054509 no 2462 0.242241497205968 836 108941 YCR052W RSC6 SGTC_777 1315-0167 517 µM -0.699302652915388 0.281587616693569 no 2463 0.24218145473057 829 4221767 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.702141457564957 0.280639939048578 no 2464 0.241295475116802 842 6710655 SGTC_9 0092-0002 10.449 µM -0.702307340690351 0.280584610065893 no 2465 0.241243758176703 846 759368 SGTC_2445 5742597 35.57 µM -0.702537310055401 0.280507914365297 no 2466 0.241172071206198 843 1774255 SGTC_2897 9048598 12.99 µM -0.70328906744574 0.280257271098772 no 2467 0.240937811200939 840 6467404 SGTC_1017 4239-0030 168 µM -0.703640012775174 0.280140299648272 no 2468 0.240828493236646 827 1149593 SGTC_850 0388-0143 75.9 µM -0.70504671206725 0.279671678879745 no 2469 0.24039058343771 837 67273 SGTC_1476 4112-3294 3.34 µM -0.70597199462517 0.279363642442244 no 2470 0.240102776792479 823 704369 SGTC_2872 9044037 25.97 µM -0.706192547455402 0.27929024238511 no 2471 0.240034202162695 841 6465195 SGTC_1419 3993-2473 62.6 µM -0.706223634140548 0.279279897479246 no 2472 0.240024537500795 848 704026 SGTC_672 1441-0018 53.7 µM -0.70678560618787 0.279092918727483 no 2473 0.239849860391161 823 251141 SGTC_122 0236-0016 402.397 µM -0.708022199668157 0.278681695095341 no 2474 0.239465735791267 850 6808838 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.710309922718451 0.277921701636016 no 2475 0.238755983936978 857 688751 SGTC_872 0588-0139 234 µM -0.711526935058429 0.277517816444766 no 2476 0.238378882896804 821 2047100 SGTC_2215 7188065 200 µM -0.711772811335791 0.277436253276443 no 2477 0.23830273578382 844 940217 SGTC_183 3914-0051 30.55 µM -0.711931834030709 0.27738350780441 no 2478 0.238253494049178 822 1596232 SGTC_3308 9128332 17.569 µM -0.713356256919286 0.276911266601456 no 2479 0.23781266697451 813 17332805 YDL196W YDL196W SGTC_680 0417-1641 114 µM -0.71405121214503 0.276681009957886 no 2480 0.237597756323151 830 2835990 SGTC_2046 4110841 106 µM -0.716334329484675 0.27592521520065 no 2481 0.236892467037206 836 44119630 YMR134W ERG29 SGTC_1005 4092-0690 4.4 µM -0.717115727564746 0.275666777193983 no 2482 0.236651346057806 853 1529343 SGTC_70 0141-0289 43.283 µM -0.717300658226766 0.275605631022846 no 2483 0.23659430059032 829 352408 SGTC_2264 7948757 110.76 µM -0.718000982710783 0.275374133561323 no 2484 0.236378340443962 831 2971411 SGTC_2572 astragaloside iv 100 µM -0.719620893371695 0.274839026959261 no 2485 0.235879222159462 847 45006101 An anti-inflammatory agent. SGTC_2179 6298986 200 µM -0.719658018077364 0.274826769530718 no 2486 0.235867790305539 830 738374 SGTC_865 0488-0499 301 µM -0.722470128825148 0.273899081657523 no 2487 0.235002742090118 817 9634651 SGTC_1047 2043-3044 82 µM -0.722981332572799 0.273730606973476 no 2488 0.234845676505458 874 669592 SGTC_1364 1653-0028 37.6 µM -0.724841670558254 0.273117938352951 no 2489 0.234274584155719 832 5718652 SGTC_1670 st016595 4.04 µM -0.725047324425005 0.273050251715354 no 2490 0.234211499112982 862 597879 SGTC_1879 gemcitabine 100 µM -0.727088108843917 0.272379021525498 no 2491 0.233585991342803 871 60750 A nucleoside analog which inhibits DNA replication. SGTC_2803 7707263 71.43 µM -0.729627221247809 0.271545033209136 no 2492 0.232809039206201 848 2199229 SGTC_2318 6029776 164 µM -0.733060412107209 0.270419404910655 no 2493 0.231760791983391 854 818325 SGTC_801 0866-0028 10.1 µM -0.733073286967474 0.270415188068114 no 2494 0.231756865891281 839 6849771 SGTC_3053 9095903 49.47 µM -0.733498547525611 0.270275922946229 no 2495 0.231627206699788 888 17174018 SGTC_2676 harmalol 100 µM -0.734590658517481 0.269918440775634 no 2496 0.231294414424864 826 5459187 A monoamine oxidase inhibitor SGTC_600 1495-0418 41.6 µM -0.734723889451144 0.26987484631625 no 2497 0.231253834041673 860 5377768 SGTC_737 1950-0117 57.9 µM -0.735626491513649 0.269579598986663 no 2498 0.230979017997567 850 5393513 SGTC_2521 angolensin 13.4 µM -0.737482568794014 0.268972972408649 no 2499 0.230414469854842 854 821428 A flavenoid. SGTC_805 3852-0218 479 µM -0.737546329179684 0.268952145616402 no 2500 0.230395090084256 835 6615355 SGTC_2610 ononetin 44.17 µM -0.738638222258874 0.268595613642273 no 2501 0.230063354048676 864 259632 SGTC_2680 butyl paraben 22.24 µM -0.740066788428525 0.268129507961641 no 2502 0.229629734772035 874 7184 An antifungal and steroid mimetic. SGTC_685 1278-0033 54.9 µM -0.740679509274023 0.267929717179675 no 2503 0.229443893171387 860 3590572 SGTC_768 0384-0033 77.3 µM -0.740986124013541 0.267829767016126 no 2504 0.22935092688892 843 3965305 YMR134W ERG29 SGTC_234 nsc-17383 10.7 µM -0.741865137190303 0.267543330763137 no 2505 0.229084525178899 826 408974 SGTC_336 4111-0029 111 µM -0.741990390849217 0.267502528036491 no 2506 0.229046578802512 855 3131175 SGTC_472 calcifediol 10 µM -0.742454962835725 0.26735121612329 no 2507 0.228905864623429 862 5283731 A vitamin D metabolite. SGTC_2164 5685496 200 µM -0.742689505639559 0.26727484152523 no 2508 0.228834842401868 868 759046 SGTC_1198 1612-1005 86.7 µM -0.742739314113114 0.267258623719154 no 2509 0.228819761423475 866 6998509 SGTC_2105 5350118 200 µM -0.742885159546812 0.267211138812789 no 2510 0.228775605643094 859 2133313 SGTC_1567 st069303 68.4 µM -0.743993135472149 0.266850538937097 no 2511 0.228440314009914 850 5581319 SGTC_1482 3346-2049 8.48 µM -0.745467458751396 0.266371089860787 no 2512 0.227994588110179 841 3826804 SGTC_1742 st038235 28.8875 µM -0.74649110605708 0.266038456920332 no 2513 0.22768540112597 860 564103 YBR002C RER2 SGTC_1849 st056239 19.2 µM -0.748620031270169 0.265347339712988 no 2514 0.227043127606388 840 5393181 SGTC_675 1309-0189 238 µM -0.74866911657282 0.265331415808095 no 2515 0.227028331164 831 4246530 SGTC_172 1112-0046 2.638 µM -0.750129082309469 0.264858005981993 no 2516 0.226588482743315 862 2802135 YIL048W NEO1 SGTC_3110 9122132 49.47 µM -0.750568870322339 0.264715484111718 no 2517 0.226456080777356 837 918317 SGTC_982 1491-0518 27.5 µM -0.751160763439094 0.264523731204561 no 2518 0.226277955243808 856 3091256 SGTC_475 α-linolenic acid 10 µM -0.751239329367616 0.264498283874092 no 2519 0.226254317403332 838 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1205 4161-2785 76 µM -0.75169056523636 0.26435215370137 no 2520 0.226118582753871 847 3498106 SGTC_2040 5100729 123 µM -0.751786338837929 0.264321143252847 no 2521 0.226089779360495 851 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_311 1315-0136 58 µM -0.752444057451811 0.264108231177621 no 2522 0.225892030068822 848 6759207 SGTC_1550 gossypolone 36.6 µM -0.752833337619012 0.263982257293353 no 2523 0.225775035411704 856 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1767 st044992 70.3 µM -0.753634876884252 0.263722969852056 no 2524 0.225534247958945 863 9600693 SGTC_165 k038-0023 64.381 µM -0.755132837454883 0.263238747707121 no 2525 0.225084641004326 861 46368543 SGTC_1111 tnp00062 510.699 nM -0.755248435921973 0.263201398892847 no 2526 0.225049965701017 852 676306 SGTC_1989 st071868 50.2 µM -0.755797054047684 0.263024182277797 no 2527 0.224885441649357 849 16414057 SGTC_2202 7226349 200 µM -0.757420235804901 0.262500213605637 no 2528 0.224399068245911 846 844334 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.757732277634071 0.262399546692995 no 2529 0.22430563587962 859 1273210 SGTC_2338 7999974 200 µM -0.758658090097874 0.262100989383932 no 2530 0.224028556738211 865 315925 SGTC_2058 5236698 133 µM -0.760140906969242 0.261623171490132 no 2531 0.223585181487707 843 766665 SGTC_2648 atorvastatin 78.68 µM -0.760906540492806 0.261376631460793 no 2532 0.223356445850091 855 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2868 9035608 32.47 µM -0.761699650248293 0.261121369750109 no 2533 0.223119642068667 854 6462614 SGTC_407 eburnamonine 100 µM -0.761815506957813 0.261084092093845 no 2534 0.223085061970225 849 3195 SGTC_3066 9117245 49.47 µM -0.763127899794998 0.260662012180053 no 2535 0.222693561298657 838 17176980 SGTC_1547 harmine 94.2 µM -0.769420595447626 0.258643102498553 no 2536 0.220821833024327 851 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3318 9139014 38.6185 µM -0.770040479992721 0.258444661501853 no 2537 0.220637940376241 876 16643984 SGTC_2702 st077768 96.8 µM -0.770820946793644 0.25819492620364 no 2538 0.220406534798729 838 6484119 SGTC_575 k072-0246 11.9 µM -0.770931493936129 0.25815956322955 no 2539 0.220373769222737 866 6796779 SGTC_869 0564-0080 44.1 µM -0.773788178901171 0.257246608646135 no 2540 0.219528032084895 853 6843321 SGTC_1044 1222-0021 1.78 µM -0.773854933707865 0.257225294875125 no 2541 0.219508291278751 844 4306703 SGTC_1678 st019265 80.2 µM -0.774876517156707 0.256899233738577 no 2542 0.21920631471394 855 5367020 SGTC_2969 9091408 28.7 µM -0.776263334041985 0.256456944606053 no 2543 0.218796758786233 865 4286311 SGTC_3287 9117173 37.0625 µM -0.776443086377488 0.256399646337292 no 2544 0.218743706428783 827 2789709 SGTC_71 0417-1750 47.813 µM -0.779731214512372 0.255352693343076 no 2545 0.217774550798582 836 6811472 SGTC_2855 9016525 58.44 µM -0.779747432580312 0.25534753498939 no 2546 0.217769776769183 867 43811474 SGTC_2649 anisomycin 9.56 µM -0.780336546108368 0.255160197197301 no 2547 0.217596403374259 858 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2398 5228213 48.84 µM -0.781026202272823 0.254940978257741 no 2548 0.217393541988697 864 80771 YMR134W ERG29 SGTC_510 ag-490 170 µM -0.781095368123819 0.254918998154833 no 2549 0.217373202978029 857 5328779 SGTC_1429 4049-0205 9.46 µM -0.782516880568399 0.254467477765534 no 2550 0.216955434369297 845 22774478 SGTC_404 fumagillin 50 µM -0.78343341238802 0.254176578644558 no 2551 0.216686320876064 861 12015870 A methionine aminopeptidase binder. SGTC_2893 9048488 25.97 µM -0.783533090952446 0.254144952064828 no 2552 0.216657064746282 890 6467338 SGTC_2711 st079103 59.1 µM -0.783656869680039 0.254105681721721 no 2553 0.216620738285 871 54693780 SGTC_1618 st003135 44.5 µM -0.785089594267832 0.25365136374085 no 2554 0.216200520140974 878 1270615 SGTC_2646 retinol 96.75 µM -0.785159142705207 0.25362932074446 no 2555 0.216180133602992 851 445354 A vitamin A analog and teratogen. SGTC_1880 MG-132 525 µM -0.785977004993039 0.253370179275276 no 2556 0.21594047945669 856 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1297 1068-0111 14.1 µM -0.787020698571972 0.253039684895668 no 2557 0.21563487475382 855 767057 SGTC_1075 aripiprazole 15.2 µM -0.78771012917053 0.252821495338089 no 2558 0.215433139674281 862 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3107 9121808 49.47 µM -0.78845056651612 0.252587273625989 no 2559 0.215216601434289 832 662681 SGTC_731 3966-0296 387 µM -0.78912624135342 0.252373637956562 no 2560 0.215019113036562 843 660956 SGTC_2364 9055074 200 µM -0.791916299930922 0.25149248357596 no 2561 0.214204741027181 883 6470630 SGTC_3040 9091894 49.47 µM -0.792289779171972 0.251374655115161 no 2562 0.214095864955809 825 25236966 SGTC_1790 st045711 43.5 µM -0.792800958284566 0.251213431222834 no 2563 0.213946899055216 826 585119 SGTC_577 r071-0003 38.6 µM -0.794155962535443 0.250786332914954 no 2564 0.213552320883178 888 4568517 YMR134W ERG29 SGTC_1264 0783-0040 158 µM -0.79465655102989 0.250628644372743 no 2565 0.213406656503268 867 2855798 SGTC_1957 st077035 62.4 µM -0.795638301366814 0.250319539376497 no 2566 0.213121148867502 881 705593 SGTC_2213 7173844 200 µM -0.796654194462671 0.249999897401972 no 2567 0.212825946701825 873 892728 SGTC_2003 4023581 200 µM -0.796655581448617 0.249999461146942 no 2568 0.212825543829279 876 16641307 SGTC_2118 5526350 200 µM -0.797139274166887 0.249847347703053 no 2569 0.212685074589127 878 743594 SGTC_1725 st036284 20.55 µM -0.798642929547189 0.24937478665078 no 2570 0.212248743789606 868 707914 SGTC_1305 1181-0477 144 µM -0.800363715534504 0.24883457043121 no 2571 0.21175004859548 881 6252086 SGTC_3210 9128157 49.47 µM -0.800476943278424 0.24879904605389 no 2572 0.211717258505397 878 17590849 SGTC_433 pimozide 108 µM -0.801033229589185 0.248624554515796 no 2573 0.211556204424131 870 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_534 k292-0788 63.4 µM -0.80203053874983 0.248311889643016 no 2574 0.211267646574609 896 4146317 SGTC_1555 citronellol 128 µM -0.803612953841564 0.247816219598542 no 2575 0.210810269778828 858 8842 A terpine precursor. SGTC_1149 3909-7961 23.3 µM -0.805047258507622 0.247367399911934 no 2576 0.210396204585111 871 735261 SGTC_2353 9059630 146.67 µM -0.807745650373436 0.246524203626174 no 2577 0.209618509124206 872 4779114 SGTC_3290 9121031 71.43 µM -0.808863431321825 0.246175369862761 no 2578 0.209296852678803 868 17014854 SGTC_1407 3909-7909 12.3 µM -0.810430215088861 0.245686858527607 no 2579 0.208846478978366 845 4411780 SGTC_382 3229-0966 23.2 µM -0.81241832016601 0.245067732511047 no 2580 0.208275818752786 883 5722370 SGTC_2122 5258151 111.688 µM -0.813166877243965 0.244834838166538 no 2581 0.208061193604092 875 2173356 SGTC_1015 4130-4525 82 µM -0.813243802077037 0.244810911728529 no 2582 0.208039145232341 885 1363237 SGTC_1247 0448-0043 5.84 µM -0.813882307618845 0.244612361728363 no 2583 0.207856188554118 900 3089013 YGL099W LSG1 SGTC_719 2810-4230 27.3 µM -0.814783911915119 0.244332146163883 no 2584 0.207598005724357 872 721079 SGTC_2630 antimycin a 100 µM -0.817631466270298 0.243448273147216 no 2585 0.206783827214103 898 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2468 5987765 72.9 µM -0.817756664137071 0.243409451758946 no 2586 0.206748073823939 864 26772094 SGTC_66 0109-0187 42.4 µM -0.81783941738338 0.24338379344629 no 2587 0.206724443568696 868 759417 SGTC_2250 alverine citrate 130 µM -0.818053658273278 0.243317373117544 no 2588 0.206663274341929 857 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_124 0136-0217 7.121 µM -0.818424429514184 0.243202447401118 no 2589 0.20655743850668 869 3976905 SGTC_2771 fluoxetine 41.05 µM -0.81920649800175 0.242960130631444 no 2590 0.206334304081517 870 3386 A selective serotonin reuptake inhibitor. SGTC_1060 3448-7350 82 µM -0.820930582404977 0.242426400501395 no 2591 0.205842904981444 886 570178 SGTC_1461 k072-0203 53.8 µM -0.821680680661375 0.242194388717056 no 2592 0.205629328670855 872 5418714 SGTC_1283 0922-0125 16.4 µM -0.82227263286988 0.242011377864174 no 2593 0.205460874361374 854 3360884 SGTC_1404 3909-7820 48.3 µM -0.822792806355489 0.241850620405985 no 2594 0.205312914088998 851 23741373 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.82324693183913 0.241710322194331 no 2595 0.205183792544381 873 688664 SGTC_453 enantio-paf c16 10 µM -0.823896469958277 0.241509729713079 no 2596 0.204999193192291 890 13871343 A lipid and platelet activating factor SGTC_778 3456-2434 196 µM -0.824974595662272 0.241176979080245 no 2597 0.204693006864618 827 5539063 SGTC_2309 7664088 163.95 µM -0.825167860608937 0.241117356512174 no 2598 0.204638148634199 879 704922 SGTC_1344 1488-0097 29.1 µM -0.825725638623851 0.240945325981891 no 2599 0.204479872474275 883 747966 SGTC_2723 salbutamol 83.58 µM -0.831799504123003 0.239076346062471 no 2600 0.202761061928835 874 9884233 β2-adrenoceptor agonist SGTC_301 4119-0100 24.5 µM -0.83318929111686 0.238649813617974 no 2601 0.202368990612131 900 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2492 derrusnin 100 µM -0.836541705382018 0.237622657164088 no 2602 0.201425112380181 886 1715307 Part of coumarin class of compounds. SGTC_1655 st012546 55.1 µM -0.8373951744631 0.237361548100058 no 2603 0.201185238643309 887 720985 YLR208W SEC13 SGTC_2657 nystatin 74.44 µM -0.839440863569918 0.236736334873123 no 2604 0.200610980506481 880 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3303 9125618 40.5795 µM -0.841765771488158 0.236026886462775 no 2605 0.199959537348931 873 22695467 SGTC_1504 k297-0033 30 µM -0.844621764913717 0.235156982511862 no 2606 0.199161026523571 833 4388117 SGTC_1280 0880-0253 10.1 µM -0.845790977984428 0.234801364644721 no 2607 0.198834679678499 889 6836607 SGTC_2714 st079313 56.9 µM -0.84585614230885 0.23478155356973 no 2608 0.19881650071876 881 2939799 SGTC_1561 5-methoxyflavone 52.9 µM -0.849229537372255 0.233757246498724 no 2609 0.197876790214169 870 94525 SGTC_374 0880-0231 82.3 µM -0.853350074966254 0.232509442730037 no 2610 0.196732599320863 886 6833587 SGTC_91 0417-1751 58.384 µM -0.853449195811244 0.232479472102638 no 2611 0.196705124890695 893 6795624 SGTC_1562 morin hydrate 59.1 µM -0.854810857822767 0.232067971355595 no 2612 0.196327933134803 875 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1948 st076329 66.6 µM -0.85486488393261 0.232051652775378 no 2613 0.196312976499724 869 24208413 SGTC_1633 st005664 67.9 µM -0.855644783009246 0.231816155535368 no 2614 0.196097145527081 910 2063822 SGTC_2824 7998404 51.95 µM -0.856009274972817 0.23170613971578 no 2615 0.195996324592649 900 837851 SGTC_1074 carmofur 3.8 µM -0.857538593246634 0.231244857760898 no 2616 0.195573647718507 896 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1286 0929-0070 131 µM -0.857609946318029 0.23122334834477 no 2617 0.195553940498971 887 1420408 SGTC_2239 6685329 187.64 µM -0.857842941841014 0.231153119511294 no 2618 0.195489597162426 875 805680 SGTC_962 1254-0300 21.5 µM -0.858159399326134 0.231057752880025 no 2619 0.195402225817672 862 7340576 SGTC_1789 tunicamycin 25 nM -0.859203153266361 0.230743366191106 no 2620 0.195114221999103 886 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2720 fluspirilene 36.88 µM -0.860092591397129 0.230475649279737 no 2621 0.194869002389296 904 3396 An atypical antipsychotic. SGTC_717 1532-0246 73.2 µM -0.862585121459849 0.22972633465291 no 2622 0.194182806835996 891 9561992 SGTC_1734 st037168 69.4 µM -0.86354756671943 0.229437365928553 no 2623 0.193918239210604 912 708907 SGTC_1492 4158-0558 28.5 µM -0.863809969350326 0.229358616385172 no 2624 0.193846145194807 868 3967268 SGTC_216 k038-0035 28.382 µM -0.865018045928221 0.2289962565482 no 2625 0.193514442048302 895 4444231 YPR107C YTH1 SGTC_2940 9060638 45.86 µM -0.866825338941203 0.228454763283305 no 2626 0.193018858142099 874 4027022 SGTC_1952 st077036 64.1 µM -0.869213824478931 0.227740240532391 no 2627 0.192365093645981 891 2937007 SGTC_3332 9141069 11.198 µM -0.869499043782521 0.227655000456753 no 2628 0.192287115427938 895 17332883 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.869912853997556 0.22753136189565 no 2629 0.192174015166213 873 688667 SGTC_3293 9120939 62.045 µM -0.869976133858279 0.22751245842006 no 2630 0.19215672346171 889 934087 SGTC_3044 9093193 49.47 µM -0.87050390665904 0.22735483228387 no 2631 0.192012542598346 872 25236277 SGTC_3175 9106517 49.47 µM -0.871885831646761 0.226942394214866 no 2632 0.191635331896414 899 41468073 SGTC_292 k038-0015 474 µM -0.872234269411149 0.226838468969403 no 2633 0.191540293903925 896 46368540 SGTC_1439 4092-1168 46 µM -0.873091502146185 0.226582904556431 no 2634 0.191306602687832 914 2886240 SGTC_566 0958-0068 16.5 µM -0.875100735051506 0.225984534916463 no 2635 0.19075954858605 876 6815365 SGTC_2516 gossypol 71.55 µM -0.875652573634253 0.225820348380911 no 2636 0.190609467623127 909 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_463 ikarugamyin 104 µM -0.87721175706093 0.225356814966811 no 2637 0.190185815653491 921 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1025 k007-0731 70 µM -0.878658403148796 0.224927220294321 no 2638 0.189793259513933 888 6256118 SGTC_3190 9110366 49.47 µM -0.879048387889918 0.224811490274811 no 2639 0.189687520129109 882 17123768 SGTC_781 4335-2806 94.4 µM -0.879262229358412 0.22474804603097 no 2640 0.189629555129285 943 845254 SGTC_2404 5161160 200 µM -0.882389755984561 0.223821306680068 no 2641 0.188783036747297 900 2831543 SGTC_796 1234-0020 70.7 µM -0.883194201626572 0.223583287412773 no 2642 0.18856567695302 862 46495034 SGTC_315 k915-0449 187 µM -0.884127488247138 0.223307327164918 no 2643 0.188313697998238 878 20970215 YNL149C PGA2 SGTC_1359 1582-0056 520 nM -0.884516788533234 0.223192273645998 no 2644 0.188208651863438 907 3661189 SGTC_1026 k007-1105 30.6 µM -0.885523976778647 0.222894766618784 no 2645 0.187937046883554 884 7066794 SGTC_2234 tolnaftate 200 µM -0.886630034463836 0.222568315594698 no 2646 0.187639059078446 915 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2291 7917025 104.35 µM -0.886909832669831 0.222485776857804 no 2647 0.187563723714971 890 2964612 SGTC_2571 chrysanthemic acid 100 µM -0.892334096358812 0.22088910572682 no 2648 0.186106941915426 929 2743 An insecticide. SGTC_1045 1348-1485 165 µM -0.893210253950852 0.220631819209621 no 2649 0.185872293953577 907 6810614 SGTC_811 0416-0114 265 µM -0.894349264972531 0.220297601728304 no 2650 0.185567524388494 875 6612453 SGTC_3258 9138477 49.47 µM -0.894472517725849 0.220261453358345 no 2651 0.185534563778982 912 4970355 SGTC_348 k064-0012 10.7 µM -0.895151849945215 0.220062275424657 no 2652 0.185352959990776 900 5066323 SGTC_109 0132-0036 33.701 µM -0.897645817138202 0.219331939148657 no 2653 0.184687202182432 857 67274 A color developer. SGTC_985 1493-0307 8.71 µM -0.898974485554682 0.21894341973712 no 2654 0.184333125531531 925 3278274 SGTC_1560 lithocholic acid 53.1 µM -0.899294249902199 0.218849975742443 no 2655 0.184247974674598 871 9903 A bile acid which acts as a detergent. SGTC_3126 9127922 49.47 µM -0.900080878580328 0.218620198745908 no 2656 0.184038605532756 914 45595682 SGTC_2221 6807166 181.081 µM -0.900447219344695 0.218513236740892 no 2657 0.183941150824708 877 674925 SGTC_965 1291-5240 308 µM -0.902188486658427 0.218005244025436 no 2658 0.183478374898926 920 2834598 SGTC_2865 9030313 51.95 µM -0.90409721935399 0.217449178427943 no 2659 0.182971926357067 912 42562754 SGTC_232 clozapine 119 µM -0.905099645913018 0.217157472626215 no 2660 0.182706299854683 903 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_97 0535-0701 19.132 µM -0.907226826658633 0.21653921314584 no 2661 0.182143430068331 894 2832013 YGL099W LSG1 SGTC_1325 1431-0015 227 µM -0.908564715247857 0.21615088160457 no 2662 0.181789969455415 899 1103340 SGTC_2333 9017922 200 µM -0.912378835488261 0.21504602277591 no 2663 0.180784663459222 904 3163164 SGTC_533 1222-0222 6.71 µM -0.913646672307914 0.214679488407004 no 2664 0.180451266867708 927 3982874 SGTC_93 0109-0045 59.227 µM -0.914195794575767 0.214520848717496 no 2665 0.180306986763098 917 88733 SGTC_2816 7982706 58.44 µM -0.914470005069401 0.214441655692259 no 2666 0.180234965947927 917 2981853 SGTC_1821 st053465 65.6 µM -0.914989618277465 0.214291636073784 no 2667 0.18009854015095 915 675086 SGTC_256 clotrimazole 625 nM -0.915119707189986 0.214254087138223 no 2668 0.180064395118666 865 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2659 sanguinarine 24.21 µM -0.917348086010314 0.213611481208891 no 2669 0.179480133552039 892 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_698 k064-0052 127 µM -0.917822204449722 0.213474902920424 no 2670 0.179355977733409 954 5088751 SGTC_2792 7535235 81.82 µM -0.918861442950923 0.213175709805046 no 2671 0.179084024770538 904 1281891 SGTC_1785 bathophenanthroline 24 µM -0.920028984428623 0.212839870609511 no 2672 0.178778806481196 871 72812 An iron chelator. SGTC_1303 1160-0052 261 µM -0.921550632565165 0.212402637731302 no 2673 0.178381509587931 882 3562476 SGTC_1839 st053978 48 µM -0.922403017726348 0.212157941484978 no 2674 0.17815919813918 927 3788398 SGTC_714 4296-0578 26.1 µM -0.922749003121075 0.212058665674071 no 2675 0.178069011185318 905 1589775 SGTC_3284 9108171 64.8615 µM -0.922804701657547 0.21204268627435 no 2676 0.17805449510854 871 8687505 SGTC_2766 oltipraz 83.91 µM -0.922823331448685 0.212037341715139 no 2677 0.178049640004234 876 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1727 st034309 9.9045 µM -0.923014803356962 0.211982416360132 no 2678 0.177999745404813 935 870305 SGTC_3248 9135562 49.47 µM -0.923699527151554 0.211786065582343 no 2679 0.177821389187036 904 17650701 SGTC_3197 9113331 49.47 µM -0.923769541236252 0.21176599440555 no 2680 0.177803158338136 907 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_488 nitrendipine 139 µM -0.924815924906834 0.211466156679405 no 2681 0.177530832765919 925 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1921 5740136 50 µM -0.925987867371191 0.211130635821223 no 2682 0.177226142724881 900 1774243 SGTC_2289 7946404 165.07 µM -0.926740373586208 0.210915361892883 no 2683 0.177030674960581 893 1246120 YPR165W RHO1 SGTC_1428 4049-0204 61.7 µM -0.927897428688532 0.210584607465359 no 2684 0.176730389175539 920 X1428 SGTC_1288 0973-0013 65.5 µM -0.928597660777801 0.210384587854691 no 2685 0.176548817306498 904 4315430 SGTC_3340 9146634 11.102 µM -0.928711581952892 0.210352057097468 no 2686 0.176519288433615 876 4907387 SGTC_1614 st002383 48.6 µM -0.929341352673846 0.210172276237444 no 2687 0.176356105446055 883 1947235 SGTC_3084 9116877 49.47 µM -0.929691637773075 0.210072319303908 no 2688 0.176265382673537 881 27241325 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.930465692636246 0.209851535017855 no 2689 0.176065009588213 892 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_998 3996-0085 177 µM -0.930492113251726 0.209844001452663 no 2690 0.17605817285124 898 715391 SGTC_1723 st034307 2.5525 µM -0.931269669075497 0.209622360647267 no 2691 0.175857043691551 901 867466 SGTC_1853 st056710 91.2 µM -0.931974117527195 0.209421677880745 no 2692 0.175674950800614 918 269167 SGTC_2472 5377652 49.4 µM -0.935742087269244 0.208350182410862 no 2693 0.174702997733101 940 1610903 SGTC_504 lovastatin 124 µM -0.935961863762884 0.208287784663032 no 2694 0.174646411648581 920 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_501 nsc-95397 161 µM -0.937454293518874 0.207864353825315 no 2695 0.174262462075978 909 262093 SGTC_989 1501-0895 10.3 µM -0.937989152409956 0.207712727957709 no 2696 0.17412499239269 897 2830112 SGTC_1963 st076565 50.3 µM -0.940936142712828 0.206878465237538 no 2697 0.173368792247504 946 4914280 SGTC_786 4544-0069 423 µM -0.94656459218323 0.205290631041751 no 2698 0.17193034685228 906 748821 YLR208W SEC13 SGTC_1193 1488-0126 41.5 µM -0.94697028413414 0.205176462245251 no 2699 0.171826960671486 895 1384710 SGTC_697 0508-1955 564 µM -0.94944065786354 0.204482070691851 no 2700 0.171198269998963 908 6243113 SGTC_2116 5511452 16.8835 µM -0.949486440061134 0.204469215095922 no 2701 0.171186632689519 931 870744 SGTC_2053 5265679 138 µM -0.950541603757794 0.20417305949246 no 2702 0.170918562368502 916 764595 SGTC_1519 esterone 74 µM -0.950727415753037 0.204120933613273 no 2703 0.170871383605009 916 698 A steroid. SGTC_89 0302-0250 142.109 µM -0.953054175859326 0.20346887845155 no 2704 0.170281311070835 938 4203518 YLR208W SEC13 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.953421006521033 0.203366190720785 no 2705 0.170188401111685 850 4000243 SGTC_2062 5245942 200 µM -0.954139024370406 0.203165283893382 no 2706 0.170006637367576 934 1376160 SGTC_511 blebbistatin 171 µM -0.955378800381338 0.2028186642182 no 2707 0.169693085379757 932 3476986 A myosin inhibitor. SGTC_413 propylparaben 100 µM -0.955507641486509 0.202782662776636 no 2708 0.169660521441267 912 7175 A pharmaceutical preservative. SGTC_631 k072-0230 41.5 µM -0.955737685671635 0.202718392147416 no 2709 0.16960238890401 942 5773147 SGTC_2860 9025725 38.96 µM -0.956679081923875 0.202455508095941 no 2710 0.169364629709209 936 40546248 SGTC_60 0986-0278 202 µM -0.95674685248598 0.202436591096122 no 2711 0.169347521823164 921 3110598 SGTC_2514 salinomycin 42.74 µM -0.956791822039421 0.202424039193439 no 2712 0.169336170397389 925 23682228 A polyether potassium ionophore. SGTC_2715 st079500 56.4 µM -0.956974291202341 0.202373113172251 no 2713 0.169290115686215 906 28246688 SGTC_3211 9128781 49.47 µM -0.9571913662553 0.202312538840358 no 2714 0.169235337017781 917 17194361 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.958556897410084 0.201931739011975 no 2715 0.168891007606371 943 91467 include heat shock SGTC_2781 5567276 71.43 µM -0.958749926244515 0.201877944521181 no 2716 0.168842370202415 932 2853274 SGTC_1362 1611-0397 101 µM -0.959103797805056 0.201779347651816 no 2717 0.168753228690635 929 27816 SGTC_1510 1123-0200 71.5 µM -0.959395197766778 0.201698178480512 no 2718 0.168679846708579 927 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2980 9014342 25.29 µM -0.960772822031176 0.201314707452722 no 2719 0.168333203319396 896 2996599 SGTC_3013 9080133 71.4286 µM -0.962147355492725 0.200932532674596 no 2720 0.167987794616649 936 17050193 SGTC_1635 st007035 42.4 µM -0.963147661607547 0.200654681785454 no 2721 0.167736713088976 892 3716403 SGTC_3246 9135460 32.98 µM -0.963420109090542 0.20057904516245 no 2722 0.167668369386858 909 41446951 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.964842132083914 0.20018454237794 no 2723 0.167311944745796 907 6312947 SGTC_2523 spermine 47.74 µM -0.965011655770692 0.200137543630066 no 2724 0.16726948688075 897 1103 A DNA binding polyamine. SGTC_82 0054-0107 293.755 µM -0.965582956372562 0.199979205091311 no 2725 0.167126453570699 912 3104697 SGTC_861 0443-0273 110 µM -0.966046849591236 0.199850690420722 no 2726 0.167010369271274 927 6149169 SGTC_456 gingerol 170 µM -0.96706056374293 0.199570029019158 no 2727 0.166756879195671 921 442793 A herb. SGTC_2119 5528445 120.635 µM -0.967702496536768 0.199392423384583 no 2728 0.166596485471431 934 791935 SGTC_2389 9091542 195.52 µM -0.969005105284991 0.199032318979397 no 2729 0.166271320979736 910 3626624 YOL127W RPL25 SGTC_1721 st082152 9.2685 µM -0.969678008000209 0.198846449546382 no 2730 0.166103507905897 926 5296051 SGTC_1070 indatraline 8.81 µM -0.970252626320939 0.198687811118732 no 2731 0.165960292312922 919 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_707 0865-0008 204 µM -0.97138020420324 0.198376735630763 no 2732 0.165679491279652 942 723043 SGTC_3204 9114183 49.47 µM -0.972020574449681 0.198200201606048 no 2733 0.165520156557268 916 17027248 SGTC_2586 curcumin 80 µM -0.973260291268292 0.197858712378048 no 2734 0.165211976252139 939 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2825 7998094 58.44 µM -0.974210214388767 0.197597289667886 no 2735 0.164976087017747 923 2987815 SGTC_1976 st070609 63.5 µM -0.974486095311024 0.197521405257355 no 2736 0.164907619897426 901 682556 SGTC_1503 4585-0012 61.3 µM -0.974831973079363 0.197426292256723 no 2737 0.16482180721649 925 2922052 SGTC_809 3998-0021 90 µM -0.975392820825654 0.197272123494633 no 2738 0.164682721717525 934 715485 SGTC_3093 9117344 49.47 µM -0.975426437541875 0.197262885069816 no 2739 0.164674387472407 903 24824913 SGTC_1776 st049249 45.9 µM -0.976923409173852 0.19685175808668 no 2740 0.164303535808012 931 1822314 SGTC_1578 josamycin 24.2 µM -0.977572025002662 0.196673784017273 no 2741 0.164143019504988 915 5282165 A P450 substrate. SGTC_888 0916-0002 6.97 µM -0.977766366287646 0.196620477583026 no 2742 0.164094944675095 921 2802138 YIL048W NEO1 SGTC_2735 sertaconazole 140 nM -0.979464165874277 0.196155155551867 no 2743 0.163675342998153 984 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3353 9151644 39.2805 µM -0.979476054059937 0.196151899670339 no 2744 0.163672407357458 921 4909158 SGTC_1104 tacrolimus 29.8 µM -0.979671255320497 0.196098443535413 no 2745 0.163624209704503 905 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_912 3474-0017 2.18 µM -0.980386075391702 0.195902764503713 no 2746 0.163447790283156 936 3360550 SGTC_1837 st055472 66.5 µM -0.981234094550884 0.19567077648612 no 2747 0.163238657268523 926 676091 SGTC_2875 9039966 71.43 µM -0.981387724344904 0.195628766664523 no 2748 0.1632007886906 938 6463691 SGTC_658 3253-0951 102 µM -0.981640117407028 0.19555976207423 no 2749 0.16313858811082 936 1184878 SGTC_767 0929-0023 86 µM -0.982042775663545 0.195449705388363 no 2750 0.163039387580826 924 1204563 SGTC_2519 cryptotanshinone 88.04 µM -0.982382520371764 0.195356873834498 no 2751 0.162955717195044 914 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1886 st057356 49.9 µM -0.987482308518221 0.193966632917268 no 2752 0.161703125823273 925 24207747 SGTC_464 bw-b 70c 158 µM -0.988476734474084 0.193696248942373 no 2753 0.161459611603011 935 5353454 SGTC_3295 9122362 53.5725 µM -0.988907519533986 0.193579190051794 no 2754 0.161354195577377 971 4730473 SGTC_3253 9135987 49.47 µM -0.989735273401417 0.19335438242725 no 2755 0.161151764614962 925 4182430 SGTC_1597 7-benzyloxygramine 47.5 µM -0.989931433767342 0.193301131077068 no 2756 0.161103817005225 920 260807 SGTC_2598 perillyl alcohol 100 µM -0.991460955436849 0.192886221236646 no 2757 0.160730274305529 940 10819 An apoptosis inducer. SGTC_1337 1486-1011 40.3 µM -0.99188926544829 0.192770132125371 no 2758 0.160625773062796 909 X1337 SGTC_1319 1306-0155 43.7 µM -0.992788738598556 0.192526477987008 no 2759 0.160406459538869 928 3122360 SGTC_414 piperonyl butoxide 100 µM -0.993534171917768 0.192324693717161 no 2760 0.160224853028751 928 5794 A potent inhibitor of cytochrome P450. SGTC_1994 st072947 40.9 µM -0.994471321120541 0.192071196712715 no 2761 0.15999673042038 932 5286565 YDL195W SEC31 SGTC_2584 androsterone 48.74 µM -0.99499452722929 0.191929759474159 no 2762 0.159869463050608 874 2754130 A steroid. SGTC_2024 5144227 134 µM -0.995171690139208 0.191881881838295 no 2763 0.159826384036172 921 3475211 SGTC_983 1491-0821 12.2 µM -0.996903153922815 0.191414345000421 no 2764 0.15940576032337 920 46495113 SGTC_359 0081-0058 15.9 µM -0.99849725085892 0.190984518290021 no 2765 0.159019148445589 909 3494159 SGTC_610 4215-0184 155 µM -0.998970992401044 0.19085689447906 no 2766 0.158904371751843 892 5605015 SGTC_1011 4112-3381 17.4 µM -0.999008745729211 0.190846726156158 no 2767 0.158895227323929 919 2877139 SGTC_585 0kpi-0023 191 µM -0.99984110448577 0.190622626597062 no 2768 0.15869370504877 889 64601 SGTC_741 4582-0002 126 µM -1.00262956654487 0.189873054586046 no 2769 0.158019812376292 915 2912688 SGTC_2064 5220758 200 µM -1.00352266993541 0.189633361381194 no 2770 0.157804372263819 930 788518 SGTC_1068 loratadine 26.9 µM -1.0039340778755 0.18952300939238 no 2771 0.157705194739449 951 3957 A H1 histamine antagonist. SGTC_2390 9097792 176.6 µM -1.00662017301902 0.188803489423442 no 2772 0.157058668218986 915 4497149 SGTC_2267 7931562 200 µM -1.00754271058931 0.188556759653866 no 2773 0.156837021877824 935 934880 SGTC_2340 7987427 183.45 µM -1.00906370141734 0.188150409771114 no 2774 0.156472042427031 919 2239331 SGTC_2817 7995342 71.43 µM -1.00918985307872 0.188116731217411 no 2775 0.156441796005367 958 18879975 SGTC_705 1124-0212 310 µM -1.00975394383622 0.187966182121456 no 2776 0.156306595369566 916 9554485 SGTC_1850 st056238 17 µM -1.01021007313754 0.187844501058785 no 2777 0.156197327109185 916 5393177 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.0111066108251 0.187605474593479 no 2778 0.155982703324624 904 688669 SGTC_180 1486-1293 102.781 µM -1.01216210795595 0.187324308830821 no 2779 0.155730275193666 925 4140536 SGTC_798 1287-0182 476 µM -1.01990915686935 0.185268613929179 no 2780 0.153885773179665 961 1649755 SGTC_287 k060-0039 29.6 µM -1.0204529510367 0.185124845143335 no 2781 0.15375684602114 932 5861974 SGTC_615 k087-0205 167 µM -1.02062742307017 0.185078732759536 no 2782 0.153715495923107 934 9642773 SGTC_345 1362-0200 395 µM -1.02212174153815 0.184684081628352 no 2783 0.153361642078425 970 1419823 SGTC_1798 st045719 60.953 µM -1.02782904998368 0.183181595853887 no 2784 0.152015124360819 895 3980186 SGTC_604 1000-0114 314 µM -1.02893263488968 0.182891952066434 no 2785 0.151755665785712 948 1572745 SGTC_2273 7815444 169.05 µM -1.02957785267179 0.182722742505196 no 2786 0.151604108118244 949 2824616 SGTC_1455 4262-0120 131 µM -1.02970470315343 0.182689487231189 no 2787 0.151574323563284 933 1529587 SGTC_2227 7312221 64.1025 µM -1.02983108166554 0.182656359447428 no 2788 0.151544653695478 960 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3267 9137951 49.47 µM -1.02996866604666 0.182620298517789 no 2789 0.151512357417149 977 16643986 SGTC_1257 0669-0121 16 µM -1.03087940257396 0.182381706183945 no 2790 0.151298688379146 921 4307855 SGTC_2117 5521686 200 µM -1.03144068279913 0.182234760527273 no 2791 0.151167105588296 953 803312 SGTC_158 k038-0087 26.446 µM -1.03170756856436 0.182164914612055 no 2792 0.151104565385175 894 X158 SGTC_1594 piperine 70.1 µM -1.0340280816567 0.18155832516763 no 2793 0.150561517712854 941 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2152 5568786 200 µM -1.0340838998462 0.181543749704039 no 2794 0.15054847114155 939 5399883 SGTC_2403 6032726 181.2 µM -1.03513019784373 0.181270671824419 no 2795 0.150304055776502 942 2881040 SGTC_2966 9084041 48.03 µM -1.03571087549795 0.181119229285964 no 2796 0.150168523554228 951 17741380 SGTC_665 3914-0008 307 µM -1.03711712084258 0.180752804636807 no 2797 0.14984063852032 947 1069549 SGTC_1822 st052468 42 µM -1.03741756078129 0.180674579446336 no 2798 0.149770648857177 933 2873678 SGTC_452 diindolylmethane 8 µM -1.0394271201083 0.180151898850055 no 2799 0.149303068258187 946 3071 Inhibits expression of several cancer promoting factors. SGTC_1760 st045453 10.4495 µM -1.03968326611349 0.180085344280367 no 2800 0.14924353878236 949 3323419 YIL048W NEO1 SGTC_55 0767-0285 6.563 µM -1.0405135751446 0.179869710724378 no 2801 0.149050680223425 933 3116166 SGTC_3147 9097027 49.47 µM -1.04406174240481 0.178950070186296 no 2802 0.148228412356033 954 25236841 SGTC_1824 st053723 68.6 µM -1.04535840618278 0.178614730726681 no 2803 0.147928676435024 942 675225 SGTC_1530 rhein 70.4 µM -1.04539837297856 0.178604400919483 no 2804 0.14791944418786 929 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2041 5107442 45.335 µM -1.04542665711763 0.178597090835907 no 2805 0.147912910843312 932 793005 SGTC_892 0929-0076 29 µM -1.05503237236602 0.176125381252633 no 2806 0.145705259730135 935 5751038 SGTC_1123 mangostin 811.285 nM -1.05719228832888 0.175572595185247 no 2807 0.145211919303696 894 5281650 An antioxidant. SGTC_749 1000-0129 128 µM -1.05784956062267 0.175404598295571 no 2808 0.145062016876224 955 708470 SGTC_2928 9011484 9.79 µM -1.05817160162746 0.1753223227598 no 2809 0.144988607831444 913 2994751 SGTC_2913 7966556 36.57 µM -1.05973802315857 0.174922480009907 no 2810 0.144631899714008 906 2976516 SGTC_2867 9039098 71.43 µM -1.0599865088443 0.174859105092476 no 2811 0.144575368514082 924 6463460 SGTC_668 1682-0499 62.6 µM -1.06056805491924 0.174710841910824 no 2812 0.144443123322071 955 682214 SGTC_2597 laccaic acid a 100 µM -1.06118563609801 0.17455347911075 no 2813 0.144302772922246 966 5491415 A textile dye. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.06199559988253 0.174347232737236 no 2814 0.144118841370621 923 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_205 1486-1330 71.903 µM -1.06426929201299 0.173769095390498 no 2815 0.143603362417569 950 4118834 SGTC_334 1502-1024 68.5 µM -1.06472604950327 0.173653101788202 no 2816 0.143499959165116 950 3296216 SGTC_1390 3413-2614 145 µM -1.06476004628569 0.173644470272727 no 2817 0.143492264798343 962 3421432 SGTC_2354 9060492 162 µM -1.06483389144769 0.173625722507762 no 2818 0.143475552653856 974 6471895 SGTC_1995 st072814 61.1 µM -1.06796689098667 0.172831505122736 no 2819 0.142767723490755 954 5769371 SGTC_703 3875-0075 71.8 µM -1.06807651200655 0.172803758112385 no 2820 0.142742999960482 979 2850814 SGTC_2101 5377231 179.231 µM -1.06832735806199 0.172740275241254 no 2821 0.142686435934137 972 2844213 SGTC_2675 theaflavin digallate 100 µM -1.06898409876492 0.172574140993093 no 2822 0.142538417294593 966 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_365 0121-0052 13.6 µM -1.06936955364146 0.172476680785859 no 2823 0.142451590431258 918 3101739 SGTC_943 3253-1379 105 µM -1.07014998990929 0.172279459156004 no 2824 0.142275900345437 937 668464 SGTC_902 1120-0002 2.07 µM -1.07199886776766 0.171812809430843 no 2825 0.141860270344901 904 3280475 SGTC_1172 0370-0043 85 µM -1.07269074923552 0.171638388945352 no 2826 0.141704946163245 960 376585 SGTC_1862 st057513 3.81 µM -1.07577688538327 0.170861764922333 no 2827 0.141013526110205 949 5393163 SGTC_1557 sumaresinolic acid 42.3 µM -1.07598993920553 0.170808233177343 no 2828 0.1409658779638 932 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2125 5246583 200 µM -1.0777642535193 0.170362837243637 no 2829 0.140569487925159 948 835267 SGTC_2302 7771753 200 µM -1.07929948861 0.169978056864436 no 2830 0.140227120403014 933 2203047 SGTC_2432 5630864 12.22 µM -1.08057392486196 0.169659064766312 no 2831 0.139943343312546 952 5714970 SGTC_233 rapamycin 362 pM -1.08063639546078 0.169643438219942 no 2832 0.139929443105464 950 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1712 st032288 53.4 µM -1.08144100276417 0.16944225433632 no 2833 0.139750495425328 947 2883011 SGTC_2 0422-0095 29 µM -1.08430961139539 0.168726234496445 no 2834 0.139113772588187 928 6790840 SGTC_2627 acetyl isogambogic acid 100 µM -1.08679667019452 0.168107027622971 no 2835 0.138563339837568 966 6857789 A caspase activator and apoptosis inducer. SGTC_3020 9089140 49.47 µM -1.08719886287014 0.168007030614007 no 2836 0.138474466635132 968 17217859 SGTC_2123 5259487 200 µM -1.08748598296205 0.167935667481501 no 2837 0.138411044986638 953 2173474 SGTC_538 2922-0838 53.3 µM -1.08767643293922 0.16788834228048 no 2838 0.138368987618337 974 777039 SGTC_891 0929-0073 133 µM -1.08892694032612 0.167577815104712 no 2839 0.138093052473481 961 5603632 SGTC_2821 7996764 71.43 µM -1.08955520064214 0.167421944628547 no 2840 0.137954563181062 922 2987135 SGTC_1907 st060210 83.7 µM -1.09037316865468 0.167219147984684 no 2841 0.137774398065069 954 688793 SGTC_1840 st055363 71 µM -1.09427971946167 0.166252792309306 no 2842 0.136916158583537 976 676033 SGTC_1442 4112-3290 3 µM -1.09450187963444 0.166197945596683 no 2843 0.136867461727179 976 704353 SGTC_2063 5246145 200 µM -1.09495307457804 0.166086590953436 no 2844 0.13676859756216 960 711240 SGTC_2385 9074692 200 µM -1.0955087467314 0.165949517651739 no 2845 0.13664690783763 952 17046906 SGTC_2373 9071805 200 µM -1.09558081665668 0.165931744787863 no 2846 0.136631130270729 978 10149009 SGTC_1975 st070967 30.8 µM -1.09770297909481 0.165408958621877 no 2847 0.136167104243178 952 261391 SGTC_1622 st003707 19.4 µM -1.10011958750014 0.16481493597251 no 2848 0.135640010262666 934 10140899 SGTC_211 3455-0679 143.504 µM -1.10036428181204 0.164754865189831 no 2849 0.135586717260297 944 748649 SGTC_470 aa-861 153 µM -1.10208422635112 0.164333030828907 no 2850 0.135212528121351 939 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1076 itraconazole 331 nM -1.10210442066638 0.16432808212505 no 2851 0.135208138878856 954 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2437 5741531 144.16 µM -1.10449458135214 0.163743045482674 no 2852 0.13468932640322 915 2262990 SGTC_2279 7948423 32.93 µM -1.10456340064448 0.163726220719317 no 2853 0.134674408628469 937 1247112 SGTC_1347 1493-0251 600 nM -1.10636362643138 0.163286504808276 no 2854 0.134284581227289 900 3986378 SGTC_2570 licareol 100 µM -1.10705033105539 0.16311897544536 no 2855 0.134136084109078 958 443158 SGTC_1454 4239-0054 42.6 µM -1.10870257942162 0.162716348673821 no 2856 0.133779254401581 945 1340767 SGTC_2066 5222451 176 µM -1.11084226533327 0.162195902520157 no 2857 0.133318125128174 915 2281147 SGTC_870 0573-2213 57.6 µM -1.11247059856706 0.161800562241908 no 2858 0.13296793238553 950 3916321 SGTC_1120 ficusin 1.78878 µM -1.11482671922175 0.161229636241139 no 2859 0.132462342109679 966 6199 A DNA cross-linker. SGTC_2939 9044578 71.43 µM -1.11553349914615 0.161058628636783 no 2860 0.132310935731149 961 2653634 SGTC_1764 st044502 93.5 µM -1.11995129417046 0.159992412591243 no 2861 0.13136725903533 956 8407 SGTC_3117 9124945 49.47 µM -1.12109889330154 0.159716201415402 no 2862 0.131122884857851 947 17592065 SGTC_1260 0700-1617 7.75 µM -1.12160933089729 0.159593446486064 no 2863 0.131014291272834 936 2853078 SGTC_3173 9105693 49.47 µM -1.1256132757278 0.158632681868608 no 2864 0.130164623155178 964 17096658 SGTC_657 3534-0529 86.7 µM -1.12611154031845 0.15851338692886 no 2865 0.130059154939839 986 1049549 SGTC_246 cycloheximide 667 µM -1.1264173771809 0.158440192351647 no 2866 0.129994447415998 948 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1072 oxiconazole 14.9 nM -1.12789576453801 0.158086689128652 no 2867 0.129681971413905 941 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2883 9059145 45.46 µM -1.12949605742359 0.15770462054456 no 2868 0.129344315891514 981 16476510 SGTC_827 3253-0474 693 µM -1.13032243832364 0.157507560488513 no 2869 0.129170191519466 952 5402065 SGTC_479 n-linoleoylglycine 10 µM -1.13456740731164 0.156497850256215 no 2870 0.128278307839522 978 6433346 An anti-infammatory. SGTC_601 0986-0029 62.9 µM -1.13560587575521 0.156251489977758 no 2871 0.12806077433245 938 24747981 SGTC_2593 nobiletin 86.24 µM -1.13684387488812 0.155958128200436 no 2872 0.127801779073952 940 72344 An anti-infammatory. SGTC_3237 9133362 49.47 µM -1.13827263888951 0.155620013492794 no 2873 0.127503327671803 971 43845137 SGTC_1294 1000-1494 117 µM -1.1405870386339 0.155073341178988 no 2874 0.12702090675813 953 712797 YDL207W GLE1 SGTC_2927 9011802 47.9 µM -1.14264347672641 0.154588665795453 no 2875 0.126593323294516 955 43912568 SGTC_1410 3909-8106 77.9 µM -1.14366010072908 0.154349431104873 no 2876 0.126382313175565 963 1039210 SGTC_2670 beta-carotene 100 µM -1.14401257793046 0.154266542404935 no 2877 0.126309210378758 919 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3174 9107204 49.47 µM -1.14545123919752 0.153928531489145 no 2878 0.126011141616173 974 3938802 SGTC_489 paxilline 115 µM -1.14622219392835 0.153747598881318 no 2879 0.125851613490849 977 105008 A toxic potassium channel blocker. SGTC_3098 9119039 49.47 µM -1.14690309184859 0.153587918509402 no 2880 0.125710837357218 953 17161528 SGTC_1974 st069448 26.9 µM -1.1469862831711 0.153568416476853 no 2881 0.125693645025493 954 6323587 YNR016C ACC1 SGTC_1787 fluconazole 80 µM -1.14702835394341 0.15355855470756 no 2882 0.125684951297655 918 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2460 5552655 174.22 µM -1.14855349625394 0.153201330743152 no 2883 0.125370071019649 962 5401989 SGTC_744 1594-0068 283 µM -1.14891429645956 0.153116903517805 no 2884 0.125295660967348 978 668392 SGTC_2541 muurolladie-3-one 83.07 µM -1.14985837222063 0.152896135786998 no 2885 0.125101104308799 938 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2087 5276107 200 µM -1.15073278349425 0.152691847139038 no 2886 0.124921092518819 955 144405 SGTC_307 1501-1223 22.3 µM -1.15502044435168 0.151692742883491 no 2887 0.124041027241072 974 2830329 SGTC_2729 fluphenazine 10.66 µM -1.15518587767161 0.151654281113592 no 2888 0.124007158312807 955 3372 An atypical antipsychotic. SGTC_2645 abamectin 100 µM -1.15634431724572 0.15138513587647 no 2889 0.123770173942923 908 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2305 7443522 69.23 µM -1.15638929377151 0.151374692696933 no 2890 0.123760979400648 941 5415886 SGTC_295 k015-0027 31 µM -1.15829414525734 0.150932841652793 no 2891 0.123372009908349 970 3887424 SGTC_2626 ethyl orsellinate 100 µM -1.16038534849217 0.150448753755057 no 2892 0.122945974655976 970 75653 A natural product. SGTC_1870 st057514 26.5 µM -1.16097367176324 0.150312750773755 no 2893 0.122826303263948 964 5393161 SGTC_1955 wogonin 32.4 µM -1.16116462378921 0.150268625915934 no 2894 0.122787479097166 956 5281703 A flavanone. SGTC_651 3253-0966 34.4 µM -1.16157027196109 0.150174918100761 no 2895 0.122705031697775 966 781462 SGTC_1376 2910-0861 41.3 µM -1.16507555913698 0.149366792835812 no 2896 0.121994204560476 983 1112859 SGTC_2616 abietic acid 100 µM -1.16519086963247 0.149340258030558 no 2897 0.12197087031104 976 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2124 5246320 200 µM -1.16523899804408 0.14932918383756 no 2898 0.12196113196564 949 579342 SGTC_847 0342-0274 5.54 µM -1.1683333930298 0.148618324242823 no 2899 0.121336155319569 972 18097 SGTC_2699 st077704 54.6 µM -1.16887908648238 0.148493199909328 no 2900 0.121226175314689 968 645852 SGTC_630 4356-0227 183 µM -1.16918421070137 0.148423267416538 no 2901 0.121164710620018 968 779312 SGTC_2114 5491910 81.25 µM -1.16961109135406 0.148325466108184 no 2902 0.121078755911814 964 2849228 SGTC_1475 4092-1048 11.7 µM -1.1734958963455 0.147437411884682 no 2903 0.120298500768609 987 2881759 SGTC_3304 9125678 46.087 µM -1.17428524220394 0.147257406287462 no 2904 0.120140396219495 972 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2100 5377183 190 µM -1.17431335575828 0.147250997877542 no 2905 0.12013476782706 944 2844202 SGTC_2079 5212404 121 µM -1.17453102808615 0.147201386376321 no 2906 0.120091195660103 973 758462 SGTC_1786 berberine 21.6 µM -1.17459802427205 0.147186118976619 no 2907 0.120077787060739 933 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1695 st026914 34.495 µM -1.17508789693485 0.14707451679464 no 2908 0.119979776134465 984 3289191 SGTC_2044 5102272 200 µM -1.17560930832382 0.146955791851259 no 2909 0.119875517086641 971 592666 SGTC_3249 9135183 49.47 µM -1.17601516423732 0.146863423293789 no 2910 0.119794408205334 941 4902779 SGTC_131 0141-0277 33.849 µM -1.17691778441762 0.146658136033419 no 2911 0.119614161473929 980 1547771 SGTC_2801 7907800 81.82 µM -1.17831083919511 0.146341684955011 no 2912 0.119336354075886 955 6620925 SGTC_3338 9144300 39.5675 µM -1.17888138568493 0.146212210106108 no 2913 0.119222705419308 951 4901274 SGTC_259 usnic acid 108.925 µM -1.18194795509269 0.145517627846378 no 2914 0.118613176141894 1002 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_491 tetrandrine 80.3 µM -1.18201902572413 0.14550155660227 no 2915 0.118599075882801 974 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3099 9120367 49.47 µM -1.18721905519435 0.144328909154067 no 2916 0.117570613269628 978 24824940 SGTC_2436 5633522 8.09 µM -1.18866979613258 0.144002895315031 no 2917 0.117284815283107 977 5724242 SGTC_681 1642-0006 26.6 µM -1.19059179530903 0.143571744645854 no 2918 0.116906937062244 1003 4446530 SGTC_2650 prasterone 100 µM -1.19156027998444 0.143354820703542 no 2919 0.116716853632606 959 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1043 0916-0009 19.3 µM -1.19744934566382 0.142040536855941 no 2920 0.115565729966297 977 3101130 SGTC_789 1309-1135 70.6 µM -1.19845310415231 0.141817340682384 no 2921 0.115370334675611 961 3092424 SGTC_1743 st037606 46.3785 µM -1.20156668601256 0.141126514910221 no 2922 0.114765727569073 961 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2139 5578692 56.4705 µM -1.20471227061556 0.140430909348121 no 2923 0.11415719868173 934 650991 YMR113W FOL3 SGTC_2056 5235370 200 µM -1.20637014941632 0.140065229128228 no 2924 0.113837400233668 985 5511916 SGTC_151 3013-0144 2.285 µM -1.20695864887637 0.13993557885874 no 2925 0.11372403463342 970 906558 YHR107C CDC12 SGTC_1209 2323-2347 50.3 µM -1.20864762074723 0.139563940369164 no 2926 0.11339912646703 947 5412760 SGTC_2931 9014674 55.67 µM -1.21056840971886 0.139142109662351 no 2927 0.113030428767403 995 2996810 SGTC_2162 5663267 200 µM -1.21114383440519 0.1390159078726 no 2928 0.112920142043867 978 6456493 SGTC_3052 9092717 49.47 µM -1.21231810593629 0.138758609187896 no 2929 0.112695317839601 980 25237534 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.21310863601414 0.138585576206694 no 2930 0.112544144318403 978 165521 SGTC_1391 3442-0225 151 µM -1.21334506097929 0.138533855554528 no 2931 0.112498960787476 980 5227075 SGTC_1128 3448-9350 235 µM -1.21428495790219 0.138328372488381 no 2932 0.112319463829889 967 619386 SGTC_2805 7950783 58.44 µM -1.21475520042525 0.138225644678667 no 2933 0.112229736040212 965 1178958 YDL195W SEC31 SGTC_1100 amiodarone 5.07 µM -1.21501962976387 0.138167901069619 no 2934 0.112179302329374 965 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2014 4013930 200 µM -1.2155592128506 0.138050122985313 no 2935 0.112076439734881 984 64556 SGTC_2842 9000675 19.48 µM -1.21621007987002 0.137908145412337 no 2936 0.111952452441364 949 2989072 SGTC_1143 3454-2408 5.08 µM -1.21697666564341 0.137741053193706 no 2937 0.111806547057495 934 X1143 SGTC_3331 9141060 1.957 µM -1.21714089476371 0.137705274251844 no 2938 0.1117753067878 967 4906567 YPR165W RHO1 SGTC_2416 tofa 880 nM -1.21846074615727 0.137417961850292 no 2939 0.111524466480362 976 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2222 6885208 172.143 µM -1.22039616542374 0.136997389932226 no 2940 0.111157365147758 1001 609514 SGTC_1395 3486-0190 4.35 µM -1.22083529352555 0.136902088742148 no 2941 0.111074193936834 990 6748079 SGTC_2995 9067767 71.4286 µM -1.22124446235341 0.13681333021087 no 2942 0.110996737154665 973 11673567 SGTC_3101 9120531 49.47 µM -1.22443340725102 0.136122919592346 no 2943 0.110394386635017 992 24824904 SGTC_2881 9058953 51.95 µM -1.22504938968048 0.135989833893516 no 2944 0.110278306105798 954 17122249 SGTC_1816 st051957 91.6 µM -1.22581797200123 0.135823903271606 no 2945 0.110133591248914 1006 674121 SGTC_1605 st000082 49.1 µM -1.22607394960969 0.135768670596076 no 2946 0.110085423981433 949 1114022 SGTC_3315 9136395 68.55 µM -1.2272852034528 0.135507525147623 no 2947 0.109857707479669 976 16876844 SGTC_2182 6325192 200 µM -1.22768709171154 0.135420954426355 no 2948 0.109782226972813 954 736248 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.22929997636063 0.135073904405493 no 2949 0.109479678077231 994 803109 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.22980186711346 0.134966035355758 no 2950 0.109385654440075 952 6708739 YPR165W RHO1 SGTC_621 3584-0052 32.1 µM -1.23034724574343 0.134848886662729 no 2951 0.109283549607759 967 2273927 SGTC_347 4534-1311 26.2 µM -1.23062228042229 0.134789834994657 no 2952 0.109232084076534 980 2862016 SGTC_272 doxorubicin 8.13 µM -1.23319939926914 0.134237373461458 no 2953 0.108750689731071 986 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2397 5161689 200 µM -1.23539869869196 0.133767137299363 no 2954 0.108341078437473 990 2259942 SGTC_748 act1.228 77.9 µM -1.23905449133207 0.132987993737254 no 2955 0.10766265939626 984 4421505 YNR035C ARC35 SGTC_2924 9010168 62.78 µM -1.24020807483906 0.13274278513096 no 2956 0.107449221243734 996 2993929 SGTC_476 mead acid 10 µM -1.24110545018364 0.13255225223357 no 2957 0.107283398219165 1006 5312531 An omega 9 fatty acid. SGTC_1406 3909-7906 11.9 µM -1.24267492879916 0.132219469875309 no 2958 0.10699382312609 958 X1406 SGTC_613 3914-0030 117 µM -1.24317314491876 0.13211395180822 no 2959 0.106902018255779 945 1145395 SGTC_2450 5739737 12.93 µM -1.24391384617861 0.131957184742985 no 2960 0.10676563640844 975 2262825 SGTC_1019 4262-0212 3.4 µM -1.24419418695799 0.131897884991635 no 2961 0.10671405134291 985 4677213 SGTC_2426 5582046 32.21 µM -1.24636168830685 0.131440019590352 no 2962 0.106315819906583 977 2251934 SGTC_3131 9127911 49.47 µM -1.2479086873862 0.131113901597234 no 2963 0.106032249429342 976 45595681 SGTC_688 0527-0193 473 µM -1.24945559223312 0.130788362787745 no 2964 0.105749243083755 1009 4007154 SGTC_858 0438-0351 2.77 µM -1.25027630714096 0.130615874236671 no 2965 0.105599315135198 986 2799119 SGTC_616 4092-0450 108 µM -1.25028322705788 0.130614420556007 no 2966 0.105598051660678 1001 787165 SGTC_2950 9072895 21.46 µM -1.25151469155849 0.130355902477865 no 2967 0.105373378485763 962 17332245 SGTC_2229 7354935 190 µM -1.25221953076758 0.130208096822455 no 2968 0.105244940581643 988 318112 SGTC_92 0063-0024 660.874 µM -1.25562010043235 0.12949662272178 no 2969 0.104626870077327 1016 3594437 SGTC_3188 9110789 49.47 µM -1.25565923251288 0.129488451134713 no 2970 0.104619772960751 995 849217 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.25746018996299 0.129112760533223 no 2971 0.104293522911279 985 7104 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.2605328297583 0.128473535253934 no 2972 0.103738606256823 1001 61125 An anti-inflammatory. SGTC_1326 1431-2094 10.8 µM -1.263891298031 0.127777363364346 no 2973 0.103134522791357 990 616278 SGTC_2274 7947094 46.08 µM -1.26662538473182 0.12721255793056 no 2974 0.102644635646681 991 2971028 SGTC_765 1319-0117 244 µM -1.26809211875776 0.126910278071187 no 2975 0.10238252784517 956 3487746 YGL099W LSG1 SGTC_1659 st012954 42.1 µM -1.2695252048301 0.12661541600386 no 2976 0.102126903414566 992 24207262 SGTC_344 k064-0035 6.43 µM -1.27342614410516 0.125815203509353 no 2977 0.101433432495514 961 5088750 SGTC_147 4466-0538 29.23 µM -1.27651443462974 0.125184199048559 no 2978 0.100886863754114 992 6742687 YHR072W ERG7 SGTC_2756 carbadox 75.1 µM -1.27898832758997 0.124680325935364 no 2979 0.100450583152379 960 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1758 st042942 75.2445 µM -1.27911581576224 0.124654398090938 no 2980 0.100428137477048 981 669317 SGTC_2629 bisabolol 100 µM -1.28132886209749 0.124204921314229 no 2981 0.100039089661106 1004 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2420 aureobasidin a 50 nM -1.28379667333695 0.123705039415524 no 2982 0.0996065539453298 986 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1581 himbacine 57.9 µM -1.28437262026999 0.123588578144722 no 2983 0.09950580413563 1018 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3255 9139072 49.47 µM -1.2851491875927 0.12343167135108 no 2984 0.0993700779477258 986 17646060 SGTC_1331 1472-0049 76.2 µM -1.28836956208936 0.122782478469118 no 2985 0.0988086744799784 985 24051409 SGTC_941 3237-0776 460 µM -1.28928693015563 0.122597985953237 no 2986 0.0986491765189557 1002 760008 SGTC_2507 purpurin 79.67 µM -1.2916139629012 0.122130867466856 no 2987 0.0982454330596115 990 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3214 9129694 49.47 µM -1.29227518747675 0.121998364403656 no 2988 0.0981309307928701 1011 17158655 SGTC_3349 9149703 23.001 µM -1.29234278307746 0.121984824583934 no 2989 0.0981192309768978 995 4910494 SGTC_417 st075190 100 µM -1.29595786465138 0.121262238294088 no 2990 0.0974950009060978 993 222757 SGTC_3319 9138450 16.7555 µM -1.29954930582173 0.120547363197706 no 2991 0.0968777420402245 960 2029690 SGTC_338 4055-0136 114 µM -1.2995824242757 0.120540784819459 no 2992 0.0968720633739365 1008 2900563 SGTC_176 1486-1328 72.834 µM -1.30109506103428 0.120240596452668 no 2993 0.0966129590658498 979 22310231 SGTC_3278 9139605 49.47 µM -1.30669707486385 0.119133444772153 no 2994 0.095657806264779 987 7958859 SGTC_1285 0929-0069 65.5 µM -1.3105149583019 0.118383034658102 no 2995 0.0950108436435346 995 1206237 SGTC_3189 9110682 49.47 µM -1.31312431640116 0.117872087853308 no 2996 0.0945705306504593 1017 17122418 SGTC_1366 1683-0113 21.9 µM -1.31370371702396 0.117758845567748 no 2997 0.094472964808959 1008 708623 SGTC_980 1473-0395 201 µM -1.31481295654024 0.117542262543464 no 2998 0.0942863859557351 986 768876 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.31883176214586 0.116759938446146 no 2999 0.0936126815671108 1004 16623 A steroid. SGTC_1699 st031318 29.054 µM -1.31976742125401 0.116578328582853 no 3000 0.0934563409614273 992 5340658 SGTC_1342 1486-1464 234 µM -1.31986508863243 0.116559383061729 no 3001 0.0934400327034878 982 3253938 SGTC_191 3914-0123 66.505 µM -1.32096403120843 0.11634636064565 no 3002 0.0932566788518946 1017 3144412 SGTC_729 4092-0585 94.1 µM -1.32110690295783 0.116318686247518 no 3003 0.0932328608545629 981 2169061 SGTC_1055 3448-0672 86 µM -1.32436860445164 0.115688161499949 no 3004 0.0926903280865964 990 748378 SGTC_1478 0453-0656 35.7 µM -1.32687515523469 0.115205268583972 no 3005 0.0922749920671936 1026 5258496 SGTC_2254 7938975 95.19 µM -1.33031793815294 0.114544346651612 no 3006 0.0917067696827989 1004 2969277 SGTC_2106 5357045 167.29 µM -1.33042240615489 0.114524333873391 no 3007 0.0916895681259745 998 668842 SGTC_842 0271-0008 11.1 µM -1.33060109402519 0.114490108675845 no 3008 0.0916601511697143 972 1221709 SGTC_1372 2752-0194 270 µM -1.33296516181553 0.114037989311886 no 3009 0.0912716183861297 989 823334 SGTC_3167 9103034 49.47 µM -1.33559394779045 0.113536738737275 no 3010 0.0908410147029923 1010 5127859 SGTC_1745 st081495 74 µM -1.33665459167402 0.113334943159085 no 3011 0.0906677052206554 970 13842402 YBL026W LSM2 SGTC_2742 clothiapine 36.27 µM -1.33696189900389 0.1132765234273 no 3012 0.0906175370061562 1000 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2912 7964298 10.93 µM -1.33712062463462 0.113246357785095 no 3013 0.0905916329667426 976 2975850 SGTC_73 0327-0325 16.231 µM -1.3384717763691 0.112989804803315 no 3014 0.0903713473782106 934 53298 SGTC_2712 st079126 47.7 µM -1.3399521088198 0.112709199849299 no 3015 0.0901304576676932 1005 3152970 SGTC_1021 4476-0760 85.3 µM -1.34200971361507 0.112319996888252 no 3016 0.0897964230711634 1010 746768 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.34604132598603 0.111560190061043 no 3017 0.0891445946425706 1003 676296 Flavone; oxidizing agent. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.34802568926288 0.111187565998363 no 3018 0.0888250601137413 1017 6708561 SGTC_661 1304-0007 33.6 µM -1.34938964353579 0.110931959752211 no 3019 0.0886059227731681 1010 3117130 SGTC_2294 7971431 200 µM -1.34955530065616 0.110900944149217 no 3020 0.0885793352087474 1023 5741572 SGTC_3081 9117243 49.47 µM -1.35097526880723 0.110635341586051 no 3021 0.0883516775308655 1006 45595589 SGTC_2877 9040724 71.43 µM -1.35226291101783 0.110394884787374 no 3022 0.0881456123515712 1009 6463895 SGTC_2248 tofa 1.1 µM -1.35324008499599 0.110212655679037 no 3023 0.0879894715924974 966 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_247 mechlorethamine 29.705 µM -1.35538754750535 0.109812942629066 no 3024 0.0876470574777006 989 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_517 1365-0151 113 µM -1.35665882032422 0.109576808015732 no 3025 0.0874448213461496 997 768657 SGTC_1061 3448-9325 110 µM -1.36034468740811 0.108894232304828 no 3026 0.0868604366363199 997 723482 SGTC_1029 k015-0030 64.7 µM -1.36267164765404 0.108464885975154 no 3027 0.0864930085949795 991 2208316 SGTC_100 0086-0128 49.5915 µM -1.36452286955091 0.108124188797771 no 3028 0.0862015307403472 1005 93297 SGTC_909 3448-9333 149 µM -1.37012505068422 0.107097863496078 no 3029 0.0853239346210952 1005 3344074 SGTC_578 3460-0051 92 µM -1.37022324101007 0.107079937795567 no 3030 0.0853086127610788 1020 2876744 SGTC_2486 5283202 22.39 µM -1.37217227583816 0.106724568189594 no 3031 0.0850049069431095 992 1377751 SGTC_3105 9121040 49.47 µM -1.37257938491921 0.10665044713589 no 3032 0.0849415721441354 957 41448907 SGTC_1393 3470-5649 58.2 µM -1.37271954710121 0.106624936853832 no 3033 0.0849197750125114 989 4108395 SGTC_2784 7567673 72.73 µM -1.37745882933258 0.105764952292143 no 3034 0.0841852176146893 979 3471247 SGTC_1612 st002233 45.4 µM -1.37991668369938 0.105320932532036 no 3035 0.0838061495541355 985 1035021 SGTC_51 1013-0126 23.419 µM -1.38131850496383 0.105068293460787 no 3036 0.0835905254477576 1005 1627850 SGTC_320 4092-0846 5.34 µM -1.3837323506341 0.10463429373595 no 3037 0.0832202119725279 999 1359356 SGTC_793 0488-0545 106 µM -1.38669080039919 0.104104149262209 no 3038 0.0827680335104512 1014 292548 SGTC_423 5-fluorouracil 457 µM -1.39125866794652 0.103289431461503 no 3039 0.0820735012421587 988 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2539 epi(13)torulosol 80 µM -1.39236087021819 0.103093539498918 no 3040 0.0819065737031574 986 6708597 SGTC_2930 9013230 14.89 µM -1.39811036608955 0.102076068298506 no 3041 0.0810399637357018 973 2995857 SGTC_2197 6588183 93.1375 µM -1.39998731806467 0.101745496849503 no 3042 0.0807585580846644 999 884136 SGTC_3154 9100113 49.47 µM -1.40197416123639 0.10139642109115 no 3043 0.0804614813649492 1007 25237525 SGTC_1174 0739-0097 51.1 µM -1.4027163282783 0.101266251105468 no 3044 0.080350723132706 1015 728447 SGTC_2948 9070189 9.45 µM -1.40424108286866 0.100999203830035 no 3045 0.0801235359947873 966 6473636 YDL196W YDL196W SGTC_473 2-arachidonoylglycerol 10 µM -1.41166671158452 0.0997060065507555 no 3046 0.0790240596766996 980 5282280 An endocannabinoid. SGTC_1459 k035-0031 35.7 µM -1.41169483756597 0.0997011314258154 no 3047 0.079019917033997 965 3877128 YMR208W ERG12 SGTC_779 1360-0071 233 µM -1.41515106044436 0.0991033832227079 no 3048 0.0785121050010897 997 7566 SGTC_1854 st056233 32.9 µM -1.41675228705802 0.098827343806045 no 3049 0.0782776819834512 1019 5393174 SGTC_823 0417-1665 178 µM -1.41695105870688 0.0987931163637503 no 3050 0.0782486184625742 1024 3429856 SGTC_2141 5621638 7.665 µM -1.42180909192023 0.0979592832752069 no 3051 0.0775408397359566 1013 2856238 SGTC_1729 st035615 45.989 µM -1.42468258393498 0.0974685108130587 no 3052 0.0771244878588809 988 17385451 SGTC_1772 st048439 82.2 µM -1.42475358047233 0.0974564079690575 no 3053 0.0771142224306599 993 2927068 YDL195W SEC31 SGTC_483 fpl-64176 144 µM -1.42910299584758 0.0967170599898309 no 3054 0.0764873162907732 1029 3423 SGTC_2240 6690706 185.951 µM -1.43156997540388 0.0962995385424863 no 3055 0.0761334637302855 1008 805876 SGTC_1473 k844-0725 134 µM -1.43202456703273 0.0962227464055409 no 3056 0.0760683953149596 1008 54682906 SGTC_2088 5278280 127.392 µM -1.43236332350965 0.0961655510605967 no 3057 0.0760199346122807 1005 791502 SGTC_1619 st003326 88.7 µM -1.43429615292253 0.0958396919006724 no 3058 0.0757438838453169 953 2849032 SGTC_2362 9071156 126 µM -1.43537583490379 0.0956580203212977 no 3059 0.075590014140993 1016 653133 SGTC_3155 9099265 49.47 µM -1.43674912275945 0.0954273117285703 no 3060 0.0753946457683349 1009 25236499 SGTC_2585 alliin 100 µM -1.43680872059308 0.0954173087371822 no 3061 0.0753861759093728 1024 87310 A garlic compound which reacts with lipids. SGTC_2687 chenodiol 100 µM -1.43972105914077 0.094929437336868 no 3062 0.0749731664239592 992 5702181 A cholesterol synthesis inhibitor. SGTC_120 rhodamine 6G 52.259 µM -1.4407287900344 0.094761052182872 no 3063 0.0748306590083191 1021 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1794 st048918 76.9 µM -1.44167051860093 0.0946038946334195 no 3064 0.0746976721422605 950 672303 SGTC_3041 9091929 49.47 µM -1.44993711974646 0.0932325857759683 no 3065 0.0735380274387148 1003 25236887 SGTC_3028 9087778 49.47 µM -1.45290247922426 0.0927442722649431 no 3066 0.0731254162575445 1003 17217395 SGTC_551 k048-0028 34.9 µM -1.45591222121038 0.0922505868930796 no 3067 0.0727084433904585 1006 6836383 SGTC_993 3909-8757 62.7 µM -1.45714576244543 0.0920488131288885 no 3068 0.0725380742409368 1017 4288324 YLR208W SEC13 SGTC_204 PMA1.184 62.41 µM -1.46220869611304 0.0912240774588276 no 3069 0.0718420146763037 1020 2252213 YGL008C PMA1 SGTC_74 000s-0487 160.283 µM -1.46236618833316 0.0911985106398161 no 3070 0.0718204448534635 1002 677548 SGTC_738 1315-0003 72.4 µM -1.47242878090559 0.0895759739905437 no 3071 0.0704525629524004 1028 6251474 SGTC_285 1486-1325 46 µM -1.47396667764689 0.0893298997080515 no 3072 0.0702452816505506 1014 22310230 SGTC_2377 9073351 62.6 µM -1.47468405841705 0.0892152859000833 no 3073 0.0701487519627735 1020 7337946 YHR072W ERG7 SGTC_700 3453-2283 142 µM -1.47913913933038 0.0885059595151169 no 3074 0.0695515657312489 1013 565664 SGTC_2964 9083345 53.42 µM -1.4804258655347 0.0883018744049168 no 3075 0.0693798157422377 991 17741579 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.48224482887345 0.0880139708302296 no 3076 0.0691375811975513 1017 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1518 st038567 90.8 µM -1.48748652736318 0.0871882355734871 no 3077 0.0684431794575432 1030 77966 SGTC_3296 9122258 64.045 µM -1.48970200605955 0.0868409712146826 no 3078 0.0681513034603586 1005 4730474 SGTC_560 2332-1943 155 µM -1.49023790015965 0.0867571281272746 no 3079 0.0680808471491953 1009 21177716 SGTC_2511 berberine 10.47 µM -1.49083755550362 0.0866633810322817 no 3080 0.0680020745516488 1011 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2448 5185112 27.17 µM -1.4919320894322 0.0864924623628976 no 3081 0.0678584746316935 990 5718189 SGTC_3134 9127454 49.47 µM -1.49653518257658 0.0857764169858263 no 3082 0.0672571233525782 1040 24262820 SGTC_1784 st039334 36.3 µM -1.498831614552 0.0854208532466974 no 3083 0.0669586603916575 1015 3496984 SGTC_1913 st060213 96.1 µM -1.50529089861799 0.084426662653007 no 3084 0.0661246520483674 1020 688959 SGTC_1156 4092-0367 4.88 µM -1.50608541389857 0.0843049757228343 no 3085 0.0660226242502285 1012 1357585 SGTC_2223 6903751 107.57 µM -1.51217849230268 0.0833761395995798 no 3086 0.0652442304741492 1013 5598863 SGTC_1152 3909-8331 15.9 µM -1.51236130492565 0.0833483907643099 no 3087 0.0652209865666298 1002 16001939 SGTC_569 4130-2812 160 µM -1.51254295492277 0.0833208252788383 no 3088 0.0651978968468166 1019 743552 SGTC_3203 9113543 49.47 µM -1.51444994975213 0.0830318512939713 no 3089 0.0649558794040896 1013 17018012 SGTC_2036 5160441 105 µM -1.51773442287219 0.0825359110849036 no 3090 0.0645406812773236 998 134534 YIL048W NEO1 SGTC_2401 5128683 200 µM -1.5185367691432 0.0824151000986454 no 3091 0.0644395687597743 1026 708373 SGTC_3240 9133527 49.47 µM -1.51999354338037 0.0821960909049581 no 3092 0.0642562991916776 1021 17617455 SGTC_531 3788-1495 174 µM -1.52030284898641 0.0821496468465396 no 3093 0.0642174391697859 1003 2896655 SGTC_1775 st081588 35.1725 µM -1.52370073343384 0.0816407351738073 no 3094 0.0637917430876312 1002 1426443 YGL099W LSG1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.52722197524552 0.0811158595860241 no 3095 0.0633529118237834 1032 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1680 diphenhydramine 100 µM -1.52849598206691 0.0809265850351503 no 3096 0.0631947201824082 1003 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1036 k216-0215 33.5 µM -1.53238086962253 0.0803514797498573 no 3097 0.0627142377136267 929 622330 SGTC_2352 9027995 87.8 µM -1.5352343901919 0.0799310256231303 no 3098 0.0623631318438347 1013 2997347 SGTC_2807 7945238 51.95 µM -1.53755757369034 0.0795899447460108 no 3099 0.0620784138520867 1041 17148797 SGTC_3286 9117135 37.221 µM -1.53854227481302 0.0794457074674249 no 3100 0.0619580401721737 1022 3438150 SGTC_1380 2291-0730 164 µM -1.54057471394906 0.0791486250577908 no 3101 0.0617101629827856 1025 2999191 SGTC_2713 st079149 53.4 µM -1.54484938608067 0.0785265408347503 no 3102 0.0611913492269071 1029 3103253 SGTC_1384 3089-0840 101 µM -1.54650936580236 0.0782859690190853 no 3103 0.0609907999623447 1024 1069836 SGTC_465 cgp-37157 41 µM -1.55483312445059 0.077088072990102 no 3104 0.059992908955472 1032 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1249 0481-0015 10.2 µM -1.56052201510695 0.0762774163018841 no 3105 0.0593182858120708 1006 4227577 SGTC_528 3492-0019 172 µM -1.56213568635294 0.0760486562800437 no 3106 0.0591280137655579 1016 2869262 SGTC_1827 berberine 7.24 µM -1.56451942304421 0.0757116850898053 no 3107 0.0588478176247486 988 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_555 4296-0685 37 µM -1.56456950574188 0.0757046174892909 no 3108 0.0588419418532577 1045 2908540 YHR072W ERG7 SGTC_1766 st045414 44.774 µM -1.56541858333887 0.075584873314796 no 3109 0.0587423969420899 1006 253960 SGTC_2759 disulfiram 3.38 µM -1.56551723010596 0.0755709706674874 no 3110 0.0587308402803549 1004 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_444 curcumin 90.4 µM -1.56719428800788 0.075334914833056 no 3111 0.0585346425962196 1008 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2283 7944793 200 µM -1.56940382354708 0.0750247682090712 no 3112 0.0582769368517575 1005 2970533 SGTC_2010 4012422 159 µM -1.56944579555093 0.0750188861497105 no 3113 0.0582720501520381 1014 952393 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.57151118873362 0.0747298711843994 no 3114 0.0580319787780351 1012 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_43 0570-0105 72.5 µM -1.57601311454885 0.0741028521159406 no 3115 0.0575113904344154 1019 1114046 YDL195W SEC31 SGTC_2168 5727979 200 µM -1.58505370072852 0.0728558466972434 no 3116 0.0564770668645602 1040 695210 SGTC_684 1140-0066 328 µM -1.58639094095179 0.0726727675863845 no 3117 0.0563253270702232 1041 6813534 SGTC_1223 0764-0573 147 µM -1.58676120627955 0.0726221375717252 no 3118 0.0562833690538789 1030 1609797 SGTC_1949 st076024 69.1 µM -1.58818431868422 0.0724277928633038 no 3119 0.0561223329970191 1033 2921930 SGTC_1159 4092-0538 61.2 µM -1.58972111424722 0.0722183709665564 no 3120 0.0559488410864156 1036 717301 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.59773474200413 0.0711338516705804 no 3121 0.0550510116851513 1037 551469 SGTC_116 0155-0182 31.788 µM -1.60236174050142 0.070513379716664 no 3122 0.0545378200488316 920 771486 SGTC_250 brefeldin a 552.239 µM -1.60369373297742 0.0703355354240549 no 3123 0.0543907889938424 1052 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1125 tnp00248 1.32998 µM -1.6065292436551 0.069958093993681 no 3124 0.0540788374451525 1024 24207736 SGTC_2268 7933382 153.85 µM -1.60811069054557 0.0697482619833969 no 3125 0.0539054691242461 1010 935025 YOR257W CDC31 SGTC_1645 Cervolide 78 µM -1.61366525826738 0.0690150997232187 no 3126 0.0533000267636825 1033 23173 A fragrance. SGTC_614 0462-0418 107 µM -1.61894977324991 0.0683231097714025 no 3127 0.0527290351788798 1014 5188303 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.62054198520675 0.0681156678868264 no 3128 0.0525579515015513 1037 229346 A bile salt which induces apoptosis. SGTC_981 1488-1094 54.9 µM -1.62057138215051 0.0681118424721382 no 3129 0.0525547969378472 1029 3449522 SGTC_1181 1222-0449 220 µM -1.62615372639176 0.0673884152954179 no 3130 0.0519584785806026 1037 658318 SGTC_2433 5607874 27.82 µM -1.62615673654236 0.067388026812372 no 3131 0.0519581584860473 1016 2252428 SGTC_1663 st014140 55.4 µM -1.62641116344676 0.0673551973229742 no 3132 0.0519311088023925 1024 4207120 SGTC_123 0083-0120 66.675 µM -1.62795627554945 0.0671560921793853 no 3133 0.0517670787024408 1053 16001701 SGTC_2038 4100038 30.985 µM -1.63019621734477 0.066868258883856 no 3134 0.05153001657107 1005 3596803 SGTC_2312 7706453 155.7 µM -1.6319516477104 0.0666433532842587 no 3135 0.0513448362753931 1037 976098 SGTC_926 2268-1401 59.4 µM -1.63393130562261 0.0663904225617131 no 3136 0.0511366377355397 1046 2931578 SGTC_2852 9023854 51.95 µM -1.63408265588717 0.0663711159425799 no 3137 0.0511207480713748 1041 19798528 SGTC_570 0987-0065 62.6 µM -1.64510316511849 0.0649769607951492 no 3138 0.0499742690026669 1008 3104428 SGTC_622 1348-1566 26.3 µM -1.64520101106992 0.0649646853472963 no 3139 0.0499641825511563 1036 7340407 SGTC_582 0987-0078 156 µM -1.64734690224089 0.0646959209562944 no 3140 0.0497433812882317 1039 1625765 SGTC_3200 9114385 49.47 µM -1.64875322479153 0.0645202535343743 no 3141 0.0495991006097628 1022 17018030 YLR208W SEC13 SGTC_231 b-estradiol 524 µM -1.65097846147277 0.0642430507222439 no 3142 0.0493714864907956 1043 450 A steroid. SGTC_2813 7971799 71.43 µM -1.65226449123549 0.0640832696444276 no 3143 0.0492403223025953 1036 2234054 SGTC_3000 9075062 71.4286 µM -1.65577266831385 0.0636489716225491 no 3144 0.0488839323668873 1005 17057871 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.66339502544494 0.0627132505856252 no 3145 0.0481166941186162 1038 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1112 tnp00069 1.16933 µM -1.66401564025026 0.0626375383563585 no 3146 0.048054651944214 1044 145826 SGTC_1289 0976-0073 69.1 µM -1.66714536235204 0.0622568113357272 no 3147 0.0477427519884 1038 3391136 SGTC_2722 naftopidil 47.16 µM -1.67367435090093 0.061468379793955 no 3148 0.0470973086549811 1036 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_24 0417-1663 219 µM -1.68242207698272 0.060424267106253 no 3149 0.046243511688341 1065 4329390 SGTC_2666 tannic acid 100 µM -1.68378104613134 0.0602633158843967 no 3150 0.0461119957712337 1024 16134267 A thiamine antagonist. SGTC_1292 0kpi-0043 232 µM -1.68995008283034 0.0595368939448692 no 3151 0.0455187524394824 1044 3333905 SGTC_1706 st031321 9.9705 µM -1.69324814623402 0.0591513625036056 no 3152 0.0452041218382624 1041 6103185 SGTC_1697 st025554 27.742 µM -1.69803588239496 0.0585951814441908 no 3153 0.0447504948274117 1042 1269519 SGTC_1206 3978-0017 132 µM -1.69949387670375 0.0584266273643591 no 3154 0.0446130836693683 1022 3873677 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.70068228777252 0.0582895208133671 no 3155 0.0445013314278181 1043 2333 A French combination drug. SGTC_2128 5255449 168.493 µM -1.70081769477537 0.0582739150086483 no 3156 0.0444886127541557 1022 736008 SGTC_369 0957-0393 4.5 µM -1.70744480120241 0.057514137096258 no 3157 0.0438697046225347 1042 6997992 SGTC_1629 st005085 44.9 µM -1.71229449769144 0.0569630880002346 no 3158 0.043421205087279 1020 24207091 SGTC_2775 cyproheptadine 69.59 µM -1.71253551890593 0.0569358106613875 no 3159 0.0433990123774756 1039 2913 A selective serotonin reuptake inhibitor. SGTC_1164 k060-0068 93.7 µM -1.71884598809887 0.0562252829131181 no 3160 0.0428212095851635 1048 5963676 SGTC_1846 st056244 14.8 µM -1.72722627130293 0.0552925324485136 no 3161 0.0420635172112806 1042 5393182 SGTC_3307 9126885 69.2785 µM -1.73937098772439 0.0539625270249817 no 3162 0.0409847640136165 1044 24824909 SGTC_3184 9108758 49.47 µM -1.74385030369665 0.0534784248812054 no 3163 0.0405925981095407 1063 902885 SGTC_346 4513-0042 7.16 µM -1.74482565765579 0.0533734710911037 no 3164 0.0405076105835657 1025 2827372 SGTC_2695 st077686 51.995 µM -1.75080723774021 0.0527333839695525 no 3165 0.0399895597338226 1039 2876092 SGTC_3068 9116768 49.47 µM -1.75125377218607 0.0526858458156497 no 3166 0.0399511033730102 1044 41904888 SGTC_1664 st014217 9.02 µM -1.7518987762916 0.052617238581825 no 3167 0.0398956075108475 1020 3982782 SGTC_500 h-89 112 µM -1.75336365673357 0.0524616868204537 no 3168 0.0397698025887309 1057 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3333 9141820 12.094 µM -1.75340294465065 0.0524575199729403 no 3169 0.0397664329619671 1032 1939433 SGTC_126 0417-1624 672.48 µM -1.75350145545923 0.052447073144499 no 3170 0.0397579849560057 1047 41912 YDL195W SEC31 SGTC_278 4092-0821 23.9 µM -1.75578011421597 0.0522058876228944 no 3171 0.0395629805683944 1061 877900 SGTC_251 melphalan 456.522 µM -1.75619624304929 0.0521619375747365 no 3172 0.0395274529936657 1064 460612 A DNA alkylator. SGTC_269 exalamide 29 µM -1.75873493178119 0.0518944464859989 no 3173 0.039311270622665 1058 3316 A derivative of salicylamide. SGTC_2321 7390090 138.78 µM -1.76095022904894 0.0516619214504578 no 3174 0.0391234136627322 1054 649046 SGTC_1440 4100-1550 40 µM -1.76264755956307 0.0514843249873554 no 3175 0.0389799752078439 1055 742806 SGTC_2591 skatole 100 µM -1.7635027917351 0.0513950237725747 no 3176 0.0389078634237532 1043 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_758 0868-0029 16 µM -1.76529614773389 0.0512081660532038 no 3177 0.0387570033099628 1028 762687 SGTC_1556 plumbagin 1.48 µM -1.76603514938722 0.0511313236295987 no 3178 0.0386949760427619 996 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3010 9080089 71.4286 µM -1.76606460621658 0.0511282625700594 no 3179 0.0386925052942122 1047 17027233 SGTC_2524 avocatin b 10.57 µM -1.76970963584834 0.0507506068691498 no 3180 0.0383877619338701 1057 6710748 SGTC_3149 9097855 49.47 µM -1.78530558695058 0.0491597569665716 no 3181 0.0371058815700095 1041 25236625 YMR079W SEC14 SGTC_3316 9136639 10.545 µM -1.7880562383305 0.0488833558147842 no 3182 0.0368834674956995 1024 4903665 SGTC_2080 5212524 12.4 µM -1.79581386806025 0.0481105106397029 no 3183 0.0362620622038759 1042 260183 SGTC_1575 cyproterone acetate 48 µM -1.80434608016482 0.0472718220342888 no 3184 0.0355885350957039 1049 9880 An androgen receptor antagonist and liver toxin. SGTC_1621 st003705 32.4 µM -1.80577968973965 0.0471320596339927 no 3185 0.0354763795877737 1042 24207032 SGTC_583 1488-1091 88.9 µM -1.80957874386292 0.0467632920414795 no 3186 0.0351805693515521 1066 4303273 SGTC_2757 clomiphene 4.22 µM -1.81000271263133 0.0467222820942868 no 3187 0.0351476832528404 1057 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2926 9010726 65.15 µM -1.81142867150022 0.0465845626329519 no 3188 0.0350372605496024 1048 2994293 SGTC_2032 5185112 25.99 µM -1.81466644449782 0.0462730672451903 no 3189 0.0347875923666505 1037 5718189 SGTC_1392 3455-1037 33.9 µM -1.81553177303114 0.0461901006987808 no 3190 0.034721113879542 1038 981132 SGTC_838 0109-0203 71.4 µM -1.82561180921182 0.0452324154227478 no 3191 0.0339543778572369 1045 759422 SGTC_1171 0368-0077 21.4 µM -1.82732139340968 0.0450715867983586 no 3192 0.0338257302307469 1058 3239779 SGTC_106 0092-0003 11.579 µM -1.82908454394901 0.0449062013257465 no 3193 0.0336934720020246 1045 1072148 SGTC_1782 st039423 80.636 µM -1.83052333893964 0.0447716030653331 no 3194 0.0335858600556386 1064 2068169 SGTC_1999 st074831 12.5 µM -1.83286756501322 0.0445529983747114 no 3195 0.0334111341512395 1051 17112523 SGTC_3043 9092303 49.47 µM -1.83326876182397 0.0445156721257287 no 3196 0.0333813062528379 1047 25236084 SGTC_3033 9090887 49.47 µM -1.83469209619942 0.0443834521980126 no 3197 0.0332756620248722 1039 19325384 SGTC_826 1683-5028 118 µM -1.83565396253967 0.0442942794363235 no 3198 0.0332044254031814 1053 722377 SGTC_1604 st002052 72.4 µM -1.8369551547063 0.0441738782897543 no 3199 0.0331082579868623 1059 6254834 YHR062C RPP1 SGTC_3339 9145883 14.936 µM -1.84342366977165 0.0435792479055094 no 3200 0.0326335884068316 1017 2030670 SGTC_990 3985-0011 41.3 µM -1.84426710995474 0.0435021914055851 no 3201 0.0325721111307812 1030 5399565 YGL099W LSG1 SGTC_1906 st060206 94.7 µM -1.84530871918493 0.0434071820416715 no 3202 0.0324963214244134 1036 5133468 SGTC_3348 9149464 3.537 µM -1.84540631813825 0.0433982882393008 no 3203 0.0324892273769213 1051 1951442 SGTC_1937 st074714 47.2 µM -1.85590025860276 0.0424505676324056 no 3204 0.0317338880655143 1050 17250970 SGTC_1166 k206-0078 225 µM -1.86206876674414 0.0419013393276104 no 3205 0.0312966989122258 1049 5404595 SGTC_2091 4-phenylthiadiazole 200 µM -1.86857539418934 0.0413282553737766 no 3206 0.0308409558676454 1061 270010 SGTC_1041 0206-0046 107 µM -1.87032444348739 0.0411752926494338 no 3207 0.0307193885764674 1055 50494 SGTC_2205 7238770 200 µM -1.90744682333936 0.0380356290342168 no 3208 0.0282313754575576 1063 279867 SGTC_2832 7992762 51.95 µM -1.90822560898923 0.0379719147572446 no 3209 0.0281810315370609 1029 2985177 SGTC_2887 9044784 58.44 µM -1.91268768807243 0.0376085383770754 no 3210 0.0278940231436506 1048 6465546 SGTC_2300 7976697 71.57 µM -1.91558954230995 0.037373748550058 no 3211 0.0277086808620765 1048 2236109 SGTC_3145 9085516 49.47 µM -1.92331707416534 0.0367543465856824 no 3212 0.027220120787922 1066 25236195 SGTC_95 0471-0001 561.058 µM -1.92909027195545 0.0362970947265543 no 3213 0.026859828233971 1068 4015405 SGTC_1457 k015-0032 57.3 µM -1.93344315938426 0.0359554228768657 no 3214 0.0265908144179355 1061 4302660 SGTC_2841 9004761 38.96 µM -1.94154496989194 0.0353265025370766 no 3215 0.0260961051718011 1049 2991039 SGTC_2136 5328288 199.296 µM -1.94251035680002 0.0352521676105584 no 3216 0.0260376736901584 1060 262395 SGTC_2789 5281112 71.43 µM -1.94667680432399 0.0349328210246644 no 3217 0.025786747101514 1045 765948 SGTC_261 5-fluorouridine 15.376 µM -1.95203631036928 0.0345255256824537 no 3218 0.025466946903942 1067 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1296 1068-0102 11.9 µM -1.96163462654998 0.0338058546994919 no 3219 0.0249025189394933 1066 767053 SGTC_1715 st032160 10.2275 µM -1.96287120363254 0.0337140414828664 no 3220 0.0248305707822524 1055 5289825 SGTC_1279 0874-0590 65.2 µM -1.96652780680234 0.03344374627664 no 3221 0.0246188367574464 1065 3523074 SGTC_3091 9116372 49.47 µM -1.9683164397694 0.0333121822167141 no 3222 0.0245158197757602 1057 17169793 SGTC_1922 5578187 25 µM -1.97086112430904 0.0331257411261423 no 3223 0.0243698814323951 1037 1350412 SGTC_554 4483-2211 187 µM -1.97240654986922 0.0330129327963498 no 3224 0.0242816073669203 1072 747107 SGTC_3108 9121785 49.47 µM -1.97338864700179 0.0329414092702226 no 3225 0.0242256500427097 1002 17140271 SGTC_2718 lomofungin 53.02 µM -1.97455774430726 0.0328564335710733 no 3226 0.0241591791771756 1062 5351222 A RNA synthesis inhibitor. SGTC_878 0828-0289 13.7 µM -1.98118883992373 0.0323778657310641 no 3227 0.0237850501452763 1054 745350 YLR208W SEC13 SGTC_2885 9057732 51.95 µM -1.99571018554698 0.0313499284100038 no 3228 0.0229827388784898 1060 6471414 SGTC_1732 st034308 51.822 µM -2.01008165003266 0.0303593193514524 no 3229 0.0222112739273072 1048 830119 SGTC_1529 apigenin 74 µM -2.01377639104855 0.0301088790077597 no 3230 0.022016507749861 1060 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_178 4092-0806 87.505 µM -2.02189332129646 0.0295647010303055 no 3231 0.0215936869454612 1034 2169044 SGTC_2773 thioridazine 9.09 µM -2.02820693324936 0.0291470881768773 no 3232 0.0212695662974135 1069 5452 An antipsychotic. SGTC_1116 jasmonic acid  1.58368 µM -2.0321787270046 0.028886894341365 no 3233 0.0210677828350221 1064 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3012 9080433 71.4286 µM -2.0365920452834 0.0286000436018632 no 3234 0.0208454703029358 1057 17688859 SGTC_963 1269-2853 151 µM -2.03840802934558 0.0284827007541478 no 3235 0.020754571986352 1063 3668223 SGTC_1349 flufenamic acid 69 µM -2.04002508984025 0.0283785490766809 no 3236 0.0206739134218 1066 3371 A non-steroidal anti-inflammatory. SGTC_1160 4092-0570 10.5 µM -2.04520718082447 0.0280469137847777 no 3237 0.0204172184250945 1075 4994975 SGTC_1472 k841-0093 193 µM -2.04676073133269 0.0279481231714409 no 3238 0.0203407915155164 1077 X1472 SGTC_2418 pentamidine 31.67 µM -2.04681559415526 0.0279446397377882 no 3239 0.020338096978192 1022 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1165 k072-0275 30.3 µM -2.0523490765829 0.0275951524837706 no 3240 0.0200678748532581 1065 6153523 YGL055W OLE1 SGTC_2193 5925765 200 µM -2.05380746211105 0.0275036518850267 no 3241 0.0199971652169691 1061 877370 SGTC_1829 berberine 14.4 µM -2.05602968646143 0.0273647137273309 no 3242 0.0198898274149961 1008 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_947 3447-0010 211 µM -2.05633237308526 0.0273458344927048 no 3243 0.0198752449571191 1070 748350 SGTC_455 paf C-16 10 µM -2.05952574522396 0.0271473178483967 no 3244 0.0197219506623081 1059 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1436 4092-1007 8.32 µM -2.06492698488877 0.026814286020081 no 3245 0.0194649546922354 1063 2881121 SGTC_1082 camptothecin 424.86 nM -2.0689497275188 0.0265684725246563 no 3246 0.0192754022390088 1024 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1077 5-fluorocytosine 377 nM -2.0731671829162 0.0263127852936861 no 3247 0.0190783616819684 1067 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1778 st046819 58.9 µM -2.07591934770255 0.0261470443000156 no 3248 0.0189507054828831 1075 671715 SGTC_2856 9022925 19.48 µM -2.08555496472802 0.0255736313115788 no 3249 0.018509477191486 1063 4944862 SGTC_837 0091-0265 12.5 µM -2.10044865017514 0.0247080498785876 no 3250 0.0178446966085107 1071 759367 SGTC_2929 9013348 24.6 µM -2.10259150955229 0.0245855586767153 no 3251 0.0177507463787795 1058 2995952 SGTC_890 0929-0006 47.2 µM -2.10306835682061 0.0245583703213493 no 3252 0.0177298972766776 1075 1378169 SGTC_2356 9061756 188.97 µM -2.10397331028808 0.0245068420552634 no 3253 0.0176903876182064 1073 20104043 SGTC_904 1141-0088 396 µM -2.10981707095555 0.0241762774610371 no 3254 0.0174370577398411 1080 1378119 SGTC_2838 9002687 71.43 µM -2.1143198386173 0.0239241308498165 no 3255 0.0172439795309464 1068 6457060 SGTC_954 1189-0853 2.85 µM -2.14217317527592 0.0224130428643709 no 3256 0.0160897746183795 1055 2828194 SGTC_1748 st037455 53.6035 µM -2.14924276150341 0.022042577422735 no 3257 0.0158075805947683 1074 580690 SGTC_932 2857-0803 154 µM -2.16467905235161 0.0212516105914443 no 3258 0.0152061361821071 1076 674898 SGTC_1063 disulfiram 1.84 µM -2.16530925094517 0.0212198354590954 no 3259 0.0151820051974039 1076 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_686 1319-0111 510 µM -2.17112078017488 0.0209287027713513 no 3260 0.0149610218118802 1066 4562600 SGTC_3054 9094397 49.47 µM -2.19316469001266 0.0198549421323153 no 3261 0.014147757783245 1079 2598354 SGTC_2665 lovastatin 100 µM -2.20474912640156 0.0193096528703007 no 3262 0.013735851870443 1077 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -2.20577240326896 0.019262104008236 no 3263 0.0136999697373266 1075 521171 SGTC_171 k064-0041 9.68 µM -2.21598543209229 0.0187929614857227 no 3264 0.0133462499319061 1058 53325 SGTC_3129 9127257 49.47 µM -2.21850782956717 0.0186786021666926 no 3265 0.0132601131688525 1069 837894 SGTC_3326 9140064 16.379 µM -2.21913540049815 0.0186502418316981 no 3266 0.0132387571512786 1077 1868434 SGTC_2244 6635614 200 µM -2.22013086199561 0.0186053314693101 no 3267 0.0132049428963701 1079 836499 SGTC_2253 7938677 135.83 µM -2.22548050159076 0.0183655556083187 no 3268 0.0130244993279131 1082 2301972 SGTC_2166 5933061 31.504 µM -2.23018838324467 0.0181567263988417 no 3269 0.0128674695734459 1080 2877375 SGTC_1485 3909-9022 254 µM -2.23198394333055 0.0180776149431916 no 3270 0.0128080120869226 1091 714516 SGTC_1278 0874-0585 172 µM -2.23692183498283 0.0178615676013236 no 3271 0.0126457245965503 1083 766306 SGTC_2725 haloperidol 53.21 µM -2.24682027575067 0.0174351078570801 no 3272 0.0123257577091177 1067 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1468 k284-1086 134 µM -2.25112205895543 0.0172524998985638 no 3273 0.0121889038199421 1077 15996457 SGTC_2910 7948405 25.97 µM -2.25149422815613 0.017236778627557 no 3274 0.0121771260258365 1064 2971328 SGTC_1184 1269-1718 139 µM -2.25163471039406 0.0172308475219741 no 3275 0.012172682841773 1075 5403821 SGTC_1057 3448-5381 134 µM -2.25804730033231 0.0169619605987258 no 3276 0.0119713553287788 1040 5497911 SGTC_308 4092-1169 104 µM -2.26364076528349 0.016730357738789 no 3277 0.0117981092198673 1073 2268590 YDL196W YDL196W SGTC_3191 9110352 49.47 µM -2.2708555279048 0.0164356230947658 no 3278 0.0115778625956632 1063 17122424 SGTC_1290 0986-0249 10.2 µM -2.2726859876155 0.0163615567688837 no 3279 0.0115225548324594 1072 53329 SGTC_2030 5175110 200 µM -2.27900924868148 0.0161078922517492 no 3280 0.0113332577615688 1082 2831986 SGTC_2640 pentamidine 10.38 µM -2.29043955986272 0.0156578997657855 no 3281 0.010997924241469 1019 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2776 terbinafine 19.92 µM -2.29867371822742 0.0153404566366918 no 3282 0.0107617370048828 1064 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2552 juarezic acid 87.02 µM -2.30232230580717 0.0152015729510599 no 3283 0.0106585014102098 1067 1549512 SGTC_2658 polymyxin b sulfate 77.05 µM -2.30342894537699 0.0151596627277964 no 3284 0.0106273603597048 1083 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2301 7769476 200 µM -2.30684446498499 0.0150309369464096 no 3285 0.0105317462056747 1069 977820 SGTC_1926 methyl fluorone black 53.6 µM -2.33402395164325 0.0140396598965112 no 3286 0.00979723389658339 1040 72721 Reacts with homocysteine. SGTC_1674 st016616 23.6 µM -2.33750571605578 0.0139168395360842 no 3287 0.00970645203554776 1067 625830 SGTC_2900 5328528 85.29 µM -2.34388928543135 0.0136940622146463 no 3288 0.00954191768609733 1072 795359 SGTC_636 0kpi-0074 126 µM -2.36236397039377 0.0130665772454655 no 3289 0.00907940211654039 1078 616434 SGTC_923 1900-2434 73.3 µM -2.36903594014509 0.0128461556825976 no 3290 0.00891726015398198 1075 5910570 SGTC_2802 7925815 54.55 µM -2.38669864908313 0.0122780956183718 no 3291 0.00850021004261026 1072 1262923 SGTC_2165 5727197 32.143 µM -2.39161410225484 0.0121239309689834 no 3292 0.0083872345017213 1087 1361712 SGTC_1189 1431-2119 7.28 µM -2.39208794098905 0.0121091588969859 no 3293 0.00837641388903954 1079 3107275 SGTC_2854 9024559 71.43 µM -2.40315256176203 0.0117686246704168 no 3294 0.00812720231422407 1060 3163529 SGTC_866 0495-0101 262 µM -2.40664176742516 0.0116629758148489 no 3295 0.00804997693937195 1059 635694 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -2.42585591237476 0.0110958238414954 no 3296 0.00763616622231421 1088 6708784 An antioxidant flavonoid SGTC_2320 7373003 200 µM -2.42905891613148 0.0110036497629857 no 3297 0.00756903608176194 1063 5415828 SGTC_244 nsc-207895 1.295 µM -2.43700255727127 0.0107779218501427 no 3298 0.00740478731489853 1079 42640 SGTC_3238 9133470 49.47 µM -2.44734593546168 0.0104900517929607 no 3299 0.00719563183957957 1077 3534688 SGTC_296 1222-0039 74.9 µM -2.45186070952644 0.0103665149649575 no 3300 0.00710598320955656 1085 5984176 SGTC_2540 epiandrosterone 100 µM -2.46020411145806 0.0101415509615193 no 3301 0.00694290094250522 1073 441302 A steroid. SGTC_2145 5634607 200 µM -2.46035717372864 0.0101374640269867 no 3302 0.00693994027163681 1088 308662 SGTC_1238 0333-0287 48.8 µM -2.4776894550264 0.00968386789529061 no 3303 0.00661180917882832 1083 7226 SGTC_2489 cantharidin 73.42 µM -2.48569044339477 0.00948052966573776 no 3304 0.00646501916562155 1068 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1796 st049173 110.4 µM -2.486286022108 0.00946554394308772 no 3305 0.00645420857402664 1079 94134 SGTC_1245 0418-0076 17.2 µM -2.48961051743204 0.00938227421036965 no 3306 0.00639415760294607 1088 6790114 SGTC_2191 5911152 200 µM -2.5216535516142 0.00861197627811475 no 3307 0.00584023420674191 1082 2875902 SGTC_1097 itavastatin 7.23 µM -2.53032675986383 0.00841325993797418 no 3308 0.00569781722585443 1084 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_393 acivicin 6.25 µM -2.53434777320094 0.00832250601841593 no 3309 0.00563284315234039 1049 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_750 4073-0104 132 µM -2.53631274192726 0.00827847036077446 no 3310 0.00560133191600163 1032 22330957 SGTC_2243 6634756 200 µM -2.54233362428058 0.00814481180147611 no 3311 0.00550575056959489 1073 885676 SGTC_2769 toremifene 3.73 µM -2.60154524487449 0.00692812492385321 no 3312 0.0046402411251644 1086 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2304 7443016 91.4 µM -2.61005545103918 0.00676714379277969 no 3313 0.00452637736354768 1084 939854 SGTC_1910 st062352 60.4 µM -2.62877652410353 0.00642459436712379 no 3314 0.0042846326973751 1080 2245730 SGTC_1224 0823-0416 294 µM -2.63154229170073 0.00637531042691052 no 3315 0.0042499143744808 1086 3598164 SGTC_526 4469-0568 170 µM -2.642733921897 0.00617928336259949 no 3316 0.00411198175256916 1089 2901964 SGTC_460 trequinsin 123 µM -2.67892958585767 0.00558135589665557 no 3317 0.00369289618375823 1091 5537 A vasodilator. SGTC_1191 1487-1166 10.6 µM -2.69216451784919 0.00537590540457621 no 3318 0.00354949584399049 1085 3955771 SGTC_711 k292-0785 179 µM -2.69913759065703 0.00527038759865484 no 3319 0.00347597138486527 1073 4146315 SGTC_1443 4112-3303 14 µM -2.74025590747837 0.00468481868881378 no 3320 0.0030695681823998 1090 704433 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.74453020945219 0.00462740968762402 no 3321 0.00302987884095878 1089 23665772 A membrane-active detergent. SGTC_1281 0884-0031 11.8 µM -2.77034588195186 0.00429382986667778 no 3322 0.00279983967460256 1090 1548255 SGTC_908 3448-7491 47.7 µM -2.78920045297664 0.00406395790003547 no 3323 0.00264191750185991 1061 1203031 SGTC_1131 3454-3128 32.3 µM -2.8680792383591 0.0032171827996024 no 3324 0.00206486045552793 1078 710982 SGTC_1740 st038286 13.222 µM -2.89360616371169 0.00297930810738689 no 3325 0.00190422759842219 1082 716786 SGTC_1847 st056231 15 µM -2.91524242452951 0.00279022848871224 no 3326 0.00177706174309459 1086 5393180 SGTC_1571 st070080 73.4 µM -2.92342478114647 0.00272159232543351 no 3327 0.00173101930251843 1089 4315245 SGTC_1896 st058441 89 µM -2.93766981773183 0.00260572825070647 no 3328 0.00165344504018891 1088 688759 SGTC_834 0312-0008 75.7 µM -2.9786505128813 0.0022968356868523 no 3329 0.00144760397883836 1092 6385573 YIL048W NEO1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.98072370141782 0.00228212870182166 no 3330 0.00143784060221189 1083 688664 SGTC_2502 avocadyne acetate 18.59 µM -3.10160966720062 0.00155863099203456 no 3331 0.000962357822053194 1082 3952079 SGTC_2954 9074818 52.69 µM -3.13696942428662 0.0013906432429139 no 3332 0.000853519640449515 1089 16648742 SGTC_1848 st056003 16.4 µM -3.14017366436143 0.0013762686266255 no 3333 0.000844238542820876 1089 146492 SGTC_1933 st074711 15.9 µM -3.17090674522585 0.00124513278003325 no 3334 0.000759819596489101 1091 17250958 SGTC_849 0386-0493 241 µM -3.17296470619085 0.00123677382787552 no 3335 0.000754454330837398 1093 726119 SGTC_298 1391-0729 10 µM -3.17780765065483 0.00121730513065789 no 3336 0.00074196581077586 1091 3237558 SGTC_286 k060-0067 22.9 µM -3.19468029956057 0.00115164730415624 no 3337 0.000699929076045903 1095 5985051 SGTC_3217 9129673 49.47 µM -3.25511523934702 0.000942200852888725 yes 3338 0.000566731818067449 1092 17248312 SGTC_1527 coumarin 137 µM -3.30539606192692 0.000795261700042441 yes 3339 0.000474211368017425 1086 323 A hepatotoxic, DNA x-linker. SGTC_1190 1486-1332 13 µM -3.30589973365732 0.000793902898636737 yes 3340 0.000473359793026081 1093 4150046 SGTC_2739 tacrine 100.86 µM -3.3277945522991 0.000736860559359099 yes 3341 0.00043768197908486 1029 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1304 1165-0502 251 µM -3.42345336749229 0.000529260611804858 yes 3342 0.000309154297505112 1093 767425 SGTC_3075 9116269 49.47 µM -3.43430856352082 0.000509484022469011 yes 3343 0.000297033762949275 1091 17015205 YNL244C SUI1 SGTC_2721 ifenprodil 61.44 µM -3.4666455565893 0.000454551570726926 yes 3344 0.000263498156929494 1090 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1909 st060837 51.5 µM -3.58901971007531 0.000292614422165844 yes 3345 0.000165961873929977 1088 678937 SGTC_1192 1488-0095 21.4 µM -3.59358551030154 0.000287768187504511 yes 3346 0.000163079271073378 1093 915875 SGTC_2566 crystal violet carbinol 226 nM -3.61994475857554 0.000261220215116901 yes 3347 0.000147332958878213 1088 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1681 tripelennamine 100 µM -3.68978338852796 0.000201504804675387 yes 3348 0.000112222539874937 1085 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_461 N-acetylfarnesylcysteine 136 µM -3.92829940879546 8.02648660167128e-05 yes 3349 4.27743316135662e-05 1095 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1574 spiramycin 23.7 µM -4.11552142643833 3.75534245042866e-05 yes 3350 1.93152553662245e-05 1092 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2836 9010338 19.48 µM -4.37723234638465 1.22944093345026e-05 yes 3351 6.00979119371642e-06 1094 2994051 SGTC_2993 9054257 71.4286 µM -4.38544212459214 1.18589080448794e-05 yes 3352 5.78752159631172e-06 1090 6470217 YGL055W OLE1 SGTC_1107 amlodipine 47 µM -4.56855189841094 5.21867174812888e-06 yes 3353 2.45552736579612e-06 1075 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3141 9094609 49.47 µM -4.84139876798589 1.44862827648154e-06 yes 3354 6.44641759160444e-07 1092 25236309 YDL196W YDL196W SGTC_127 0180-0333 59.125 µM -5.4454256092133 6.60756874216871e-08 yes 3355 2.58408297949596e-08 1091 771601 SGTC_141 0443-0274 32.331 µM -11.721890757065 7.55510721547748e-31 yes 3356 4.92249198912543e-32 1094 1627241