SGTCid condition conc unit STE13|YOR219C.score STE13|YOR219C.strain.pval STE13|YOR219C.strain.significant STE13|YOR219C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2557 derrustone 83.84 µM 4.36273533538011 6.8551548975743e-06 yes 1 6.42231486687072e-06 23 629853 An antioxidant. SGTC_390 dec-rvkr-cmk 16.7 µM 4.00451328112656 3.32394363855557e-05 yes 2 3.10726499268919e-05 24 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1905 st060207 84.5 µM 3.79370957445932 7.9442066634071e-05 yes 3 7.42066270738052e-05 16 1948547 SGTC_313 3474-0040 5.03 µM 3.71405343752805 0.000109198682581134 yes 4 0.000101982847393574 82 1043375 YIL048W NEO1 SGTC_3115 9123671 49.47 µM 3.67554044765572 0.000127079172788041 yes 5 0.000118673215855589 5 3286988 SGTC_3143 9086658 49.47 µM 3.58736750217756 0.000178868051121294 yes 6 0.000167016687385863 64 25236626 SGTC_2317 5986382 200 µM 3.53365399885512 0.00021947886463858 yes 7 0.000204928621111291 23 877883 SGTC_2558 carylophyllene oxide 100 µM 3.53080490277763 0.000221856785093032 yes 8 0.000207148605045489 24 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1928 4'-methoxychalcone 40.3 µM 3.50694363984547 0.000242737109857663 yes 9 0.000226642572003714 20 641818 SGTC_2364 9055074 200 µM 3.3914799494834 0.000372255320895194 yes 10 0.000347581246631829 34 6470630 SGTC_2822 7994718 71.43 µM 3.34876804250682 0.000434653631311414 yes 11 0.000405858609216119 33 1018011 SGTC_1214 0358-0031 63.7 µM 3.34507594635479 0.000440479586152817 yes 12 0.000411300211100156 33 4301366 SGTC_253 dyclonine 31.25 µM 3.3024593236873 0.000513174413677051 yes 13 0.000479204936258496 57 3180 An oral anasthetic. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 3.21854502395216 0.000689777434355983 yes 14 0.000644213707661524 78 442882 SGTC_1072 oxiconazole 14.9 nM 3.20162928789954 0.000731562200767734 yes 15 0.000683263681995479 79 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_611 3453-1652 23.7 µM 3.19665917030887 0.000744275461042521 yes 16 0.000695145482392518 56 1560575 SGTC_1028 k015-0029 4.8 µM 3.17008453741813 0.000815773752695965 yes 17 0.000761972965476285 55 4588309 SGTC_2911 7942208 15.64 µM 3.13794613928901 0.000910667245099044 yes 18 0.000850680685370094 34 1243384 SGTC_551 k048-0028 34.9 µM 3.11930060690623 0.000970268782757096 yes 19 0.000906404550071829 52 6836383 SGTC_1269 0831-0796 3.05 µM 3.0876483929068 0.0010797046346941 no 20 0.00100873508695315 41 927758 SGTC_1888 azatryptophan 97.5 µM 3.03225655734575 0.00129880525064277 no 21 0.00121366400495571 48 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_844 0330-0132 15.3 µM 2.99450701145599 0.00147065314399505 no 22 0.00137444368932613 42 2828079 SGTC_1955 wogonin 32.4 µM 2.93154839557554 0.00180395148046274 no 23 0.0016863840536262 64 5281703 A flavanone. SGTC_3092 9117248 49.47 µM 2.93015408653179 0.00181205480520335 no 24 0.00169396980634302 25 17141857 SGTC_2465 5809242 33.21 µM 2.91894754409349 0.00187839600235968 no 25 0.00175607659410438 24 2731748 SGTC_300 r073-0011 5.04 µM 2.91328514250766 0.00191274939361715 no 26 0.00178823930121815 67 2735780 SGTC_2912 7964298 10.93 µM 2.89983558224439 0.00199664669698434 no 27 0.00186679223576557 161 2975850 SGTC_2905 7799065 20.05 µM 2.89664501317662 0.00201703331018561 no 28 0.00188588139825028 48 1296806 SGTC_2005 4024620 188 µM 2.89620247331376 0.00201987585756876 no 29 0.00188854307644152 73 236743 SGTC_2942 9052777 62.25 µM 2.87491600303429 0.00216097453121776 no 30 0.00202067497753441 97 6469503 SGTC_777 1315-0167 517 µM 2.84032053469839 0.00240944938161587 no 31 0.00225341118843037 71 4221767 SGTC_3109 9122853 49.47 µM 2.82016073903831 0.00256589504501676 no 32 0.00239997995702238 48 1234709 SGTC_1842 st055362 61.2 µM 2.79267572215746 0.0027939747801019 no 33 0.00261370333010615 77 676032 SGTC_1796 st049173 110.4 µM 2.78102947563976 0.00289601946955164 no 34 0.0027093408511759 45 94134 SGTC_898 1000-0849 28.3 µM 2.77712568727368 0.00293096918369585 no 35 0.00274209836516745 45 6751807 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.77119806285454 0.00298476510271769 no 36 0.0027925221519248 249 16725076 SGTC_2319 6033012 152.6 µM 2.76744949212253 0.00301924270839531 no 37 0.0028248399527454 87 847246 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.75163856905465 0.00316864596293175 no 38 0.00296489633237282 79 16486 A toxic proline analog. SGTC_650 1328-0195 38 µM 2.75106921608559 0.00317414800262818 no 39 0.00297005453406012 86 2780821 SGTC_2961 9083290 32.55 µM 2.75106873937616 0.00317415261299135 no 40 0.0029700588563198 75 17741490 SGTC_2868 9035608 32.47 µM 2.74931107835831 0.00319119237596583 no 41 0.00298603392470958 74 6462614 SGTC_2343 7990716 14.84 µM 2.71992432252969 0.0034885403246221 no 42 0.00326484291672879 80 6456862 SGTC_1084 voriconazole 435 nM 2.70689149322758 0.00362820195648949 no 43 0.00339582257654275 89 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_874 0599-0792 117 µM 2.69508286660597 0.00375905578976886 no 44 0.00351855637661991 106 765305 SGTC_513 4245-1575 41.7 µM 2.67736720648223 0.00396331008119512 no 45 0.00371016302303992 234 719745 SGTC_2428 5615643 7.78 µM 2.66096012771614 0.00416128417331124 no 46 0.00389590917562093 96 2253075 SGTC_298 1391-0729 10 µM 2.64974039873424 0.00430171272184343 no 47 0.00402768204019569 75 3237558 SGTC_1941 st076221 61.8 µM 2.64948656306284 0.004304938212199 no 48 0.00403070889111506 180 2828568 SGTC_2448 5185112 27.17 µM 2.63800989558671 0.00445304986230091 no 49 0.00416970741657006 77 5718189 SGTC_656 4090-1979 187 µM 2.60851875435005 0.0048547296088146 no 50 0.00454675142981452 110 22330961 SGTC_1080 nisoldipine 24.4 µM 2.59678586031056 0.00502331267646586 no 51 0.00470502843574377 111 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3130 9127414 49.47 µM 2.58065690921298 0.00526356517010138 no 52 0.00493062655933049 75 1494646 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.5768484610669 0.00532176539854777 no 53 0.00498528257310384 103 16623 A steroid. SGTC_2068 5226020 147 µM 2.57644347204918 0.00532798793003691 no 54 0.00499112630278399 129 1810509 SGTC_347 4534-1311 26.2 µM 2.57248383325069 0.00538916826896762 no 55 0.0050485835808528 91 2862016 SGTC_3102 9121669 49.47 µM 2.57041922544646 0.00542131556944647 no 56 0.00507877556736059 59 41905072 SGTC_1213 1315-0166 115 µM 2.555984797162 0.00565087031675466 no 57 0.00529438725140989 112 768401 SGTC_523 1934-0222 13.7 µM 2.53643929157191 0.00597544917060105 no 58 0.00559930787805365 123 1361595 SGTC_3163 9099914 49.47 µM 2.53151694941292 0.0060597529908848 no 59 0.00567851641849596 29 16268368 SGTC_1795 st049545 62.3 µM 2.52767511615075 0.00612628186807086 no 60 0.00574102736504335 83 5291882 SGTC_2956 9076196 2.52 µM 2.51238680006784 0.0063974846104118 no 61 0.00599587853305682 116 16423868 SGTC_2337 9009472 200 µM 2.50157415446951 0.00659565423423067 no 62 0.00618212730650633 148 5742383 SGTC_1036 k216-0215 33.5 µM 2.492084320971 0.00677403205458632 no 63 0.00634979421646347 173 622330 SGTC_775 4577-0580 57.3 µM 2.49119687149487 0.00679092915680303 no 64 0.00636567765236054 86 2006902 SGTC_2117 5521686 200 µM 2.46299644225001 0.00734762292950788 no 65 0.00688906415132576 124 803312 SGTC_2458 5808907 16.39 µM 2.44738796283119 0.00767272447256039 no 66 0.00719479273502622 75 2731747 SGTC_341 1486-1430 230 µM 2.43799595703421 0.00787439061869101 no 67 0.00738446959270389 129 2054753 YPL210C SRP72 SGTC_1951 sophoraflavanone G 9.2 µM 2.437108569103 0.00789368364687273 no 68 0.00740261673955424 139 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_524 r073-0010 27.8 µM 2.43190422956341 0.00800767222001586 no 69 0.00750983905635984 160 2772106 SGTC_2872 9044037 25.97 µM 2.42627752526744 0.00813253737614515 no 70 0.00762729999639058 62 6465195 SGTC_1226 3909-7979 35.4 µM 2.4120874050429 0.00845506523465838 no 71 0.00793073927519967 146 6615510 SGTC_525 k781-2675 26.7 µM 2.40786957473933 0.00855307225868537 no 72 0.00802295613717478 169 3651118 YDL195W SEC31 SGTC_2979 9012552 45.46 µM 2.38021507894759 0.0092207022160357 no 73 0.00865126790206153 70 17100905 SGTC_2950 9072895 21.46 µM 2.37677693889455 0.0093068129310717 no 74 0.00873232291127838 187 17332245 SGTC_2844 9010103 25.97 µM 2.34136913452602 0.0102353695829885 no 75 0.00960658015203085 171 2480525 SGTC_1562 morin hydrate 59.1 µM 2.33764915097769 0.010337463845026 no 76 0.00970272799678504 137 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3134 9127454 49.47 µM 2.31669286521529 0.0109293544992527 no 77 0.0102602342564035 106 24262820 SGTC_3161 9100388 49.47 µM 2.30308248927072 0.0113293744497303 no 78 0.0106371011686857 100 25236368 SGTC_1029 k015-0030 64.7 µM 2.302495766457 0.0113469011266762 no 79 0.0106536149480405 163 2208316 SGTC_3137 9097352 49.47 µM 2.29598137263167 0.0115430886986493 no 80 0.0108384732301209 202 44120435 SGTC_2673 kobusone 100 µM 2.28911255834362 0.0117531340270292 no 81 0.0110364066708262 85 6710676 An epoxy ketone and protein crosslinker. SGTC_3077 9117319 49.47 µM 2.27744217278629 0.0121176190467443 no 82 0.0113799170667624 115 17154678 SGTC_1632 st005650 90 µM 2.25660675375274 0.0127927411110799 no 83 0.012016328992019 153 2759605 SGTC_838 0109-0203 71.4 µM 2.24360800708297 0.0132302178786678 no 84 0.0124288168132664 138 759422 SGTC_543 3844-1095 191 µM 2.22988195633357 0.0137061436446222 no 85 0.012877640286459 207 4230703 SGTC_545 4218-0007 221 µM 2.21873995673717 0.0141032635959584 no 86 0.0132522104974542 172 2840508 SGTC_2355 9061122 103.12 µM 2.21735366095109 0.0141533604464407 no 87 0.0132994668232575 129 5302957 SGTC_2047 4141938 200 µM 2.20178357354257 0.0147266335464675 no 88 0.0138402999739085 119 3807862 SGTC_929 2805-0021 398 µM 2.1895401594726 0.0151913453547371 no 89 0.0142788014859446 167 3098024 SGTC_2850 9015429 58.44 µM 2.18561830871716 0.0153428430433672 no 90 0.0144217709962597 166 6457570 SGTC_2689 tacrolimus 100 µM 2.18402479506226 0.0154047687502065 no 91 0.0144802130636289 202 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3298 9116858 71.43 µM 2.16295125680609 0.0162441066397368 no 92 0.0152724644080331 160 2506942 SGTC_48 0382-0018 55 µM 2.16280111330775 0.016250224535027 no 93 0.0152782399740704 154 762596 SGTC_392 N-ethylmaleimide 8.33 µM 2.16194749885344 0.0162850442740006 no 94 0.0153111116013109 160 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2313 7726885 200 µM 2.16004768341315 0.0163627689825043 no 95 0.0153844892039584 201 726423 SGTC_1978 st071761 42 µM 2.15350332461965 0.0166329464549434 no 96 0.0156395715453784 142 5147680 SGTC_1241 0364-0022 50.8 µM 2.13912359316152 0.0172400354094263 no 97 0.0162128300541389 200 4563895 SGTC_3103 9120822 49.47 µM 2.13772838620784 0.017299933800535 no 98 0.0162693971197988 172 17141819 SGTC_2552 juarezic acid 87.02 µM 2.1215010506472 0.0180097559327474 no 99 0.016939829809554 221 1549512 SGTC_2342 7990637 118.86 µM 2.11644890482887 0.0182357568264325 no 100 0.0171533232368907 210 2033102 YER133W GLC7 SGTC_530 4358-1714 28 µM 2.10932089127721 0.0185587259609549 no 101 0.0174584463592013 238 1564641 SGTC_1123 mangostin 811.285 nM 2.10304499878115 0.0188471048421261 no 102 0.0177309180688842 235 5281650 An antioxidant. SGTC_2821 7996764 71.43 µM 2.10196151669005 0.0188972750709331 no 103 0.0177783235070711 247 2987135 SGTC_2280 7785178 200 µM 2.08853628147524 0.0195284093251536 no 104 0.0183747430739736 165 2954328 SGTC_2001 4023502 57.655 µM 2.08197691336297 0.0198432263711487 no 105 0.0186722892670399 212 108941 YCR052W RSC6 SGTC_2865 9030313 51.95 µM 2.07533903294609 0.0201661859086838 no 106 0.0189775621442355 149 42562754 SGTC_1247 0448-0043 5.84 µM 2.06954228380868 0.020451856334715 no 107 0.0192476138611307 274 3089013 YGL099W LSG1 SGTC_1903 st060211 78.3 µM 2.06702500542384 0.0205769744851293 no 108 0.0193658989012452 235 688960 SGTC_2984 9022109 38.96 µM 2.04555027541117 0.0216709459167918 no 109 0.0204003189834291 133 6459207 SGTC_621 3584-0052 32.1 µM 2.04431291900272 0.0217354493884739 no 110 0.0204613218896061 212 2273927 SGTC_1500 4488-1866 171 µM 2.04045431783277 0.0219376409410886 no 111 0.0206525482802294 202 2900003 SGTC_1111 tnp00062 510.699 nM 2.03667565460125 0.0221371805569825 no 112 0.020841277884668 178 676306 SGTC_1244 0416-0015 52.5 µM 2.03477543584584 0.0222381027390999 no 113 0.0209367368989032 229 96201 SGTC_2418 pentamidine 31.67 µM 2.02815247348825 0.0225928933074112 no 114 0.0212723443970594 235 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_170 4197-0004 226 µM 2.02779107000249 0.0226123901390223 no 115 0.0212907880768586 167 218692 SGTC_1747 st037496 66.6 µM 2.0225112799084 0.0228988428485961 no 116 0.0215617797378585 234 723305 SGTC_1108 betulinic acid 729.144 nM 2.01045181027033 0.0235646058478013 no 117 0.0221916958329252 209 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_162 k030-0015 37.8 µM 2.00934979773395 0.0236262480515326 no 118 0.0222500251227357 184 1809920 YMR134W ERG29 SGTC_3057 9095946 49.47 µM 2.00854853159875 0.0236711527968908 no 119 0.0222925171438774 167 24540043 SGTC_2079 5212404 121 µM 2.00607068197942 0.0238104714177329 no 120 0.0224243536661005 188 758462 SGTC_1786 berberine 21.6 µM 1.99350612449192 0.0245275741510815 no 121 0.0231030267856367 257 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2546 rhodinyl acetate 100 µM 1.99122674079319 0.0246595898259846 no 122 0.0232279826370867 217 6708682 SGTC_2528 xanthyletin 44.79 µM 1.98522913310277 0.0250098056954525 no 123 0.0235594922073008 197 65188 An natural product with antifungal activity of unknown mechanism. SGTC_684 1140-0066 328 µM 1.98291726467519 0.0251459105948465 no 124 0.0236883359291176 266 6813534 SGTC_2516 gossypol 71.55 µM 1.98132385346894 0.0252400792311693 no 125 0.0237774835120102 236 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1295 1013-0063 9.78 µM 1.97899651654883 0.0253781528352651 no 126 0.023908199231775 217 6826038 SGTC_3325 9138760 55.175 µM 1.97619973165154 0.0255449137721995 no 127 0.0240660801443138 225 43844959 SGTC_3286 9117135 37.221 µM 1.97568555220743 0.025575671842083 no 128 0.0240952011323998 221 3438150 SGTC_1956 st077085 54 µM 1.97385434947221 0.0256854658580569 no 129 0.0241991534131487 254 24208685 SGTC_3258 9138477 49.47 µM 1.97299437398766 0.0257371636807161 no 130 0.0242481016614446 207 4970355 SGTC_2034 5197015 53.07 µM 1.96467097330048 0.0262420440884163 no 131 0.0247261658015899 221 780676 SGTC_1205 4161-2785 76 µM 1.95954311800782 0.0265571918610141 no 132 0.025024607720982 223 3498106 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.953644817237 0.0269235936667131 no 133 0.0253716182675228 230 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1507 4075-3230 155 µM 1.95352678280564 0.0269309688066808 no 134 0.0253786034359314 162 659771 SGTC_460 trequinsin 123 µM 1.93832874211442 0.0278947755222624 no 135 0.0262915639705854 169 5537 A vasodilator. SGTC_3290 9121031 71.43 µM 1.93168332095816 0.0283251442637485 no 136 0.0266993023304671 200 17014854 SGTC_3044 9093193 49.47 µM 1.93144580654509 0.0283406278140202 no 137 0.0267139725410907 275 25236277 SGTC_3279 9140807 49.47 µM 1.92762368170872 0.0285907621017669 no 138 0.0269509755286461 191 45595718 SGTC_677 0929-0063 136 µM 1.92640551864874 0.028670868140927 no 139 0.0270268794474651 169 1539583 SGTC_1608 st001473 40.5 µM 1.92155662596679 0.0289915822370195 no 140 0.0273307853660284 257 7292267 SGTC_3084 9116877 49.47 µM 1.92092232476001 0.0290337556791769 no 141 0.0273707503984463 167 27241325 SGTC_740 k014-0057 261 µM 1.91187541404819 0.0296408358099876 no 142 0.0279460879347713 273 4012779 SGTC_1208 2323-2347 50.3 µM 1.90787008718581 0.0299129523472168 no 143 0.0282040046553984 218 5412760 SGTC_1683 st010134 710 nM 1.90761399442797 0.0299304211907436 no 144 0.0282205625224769 269 3818134 SGTC_2333 9017922 200 µM 1.90297834887281 0.0302480977623693 no 145 0.0285216852208829 243 3163164 SGTC_2087 5276107 200 µM 1.89332400598527 0.030918675642516 no 146 0.0291573973048677 242 144405 SGTC_2308 7584454 197.62 µM 1.89069966002649 0.0311030713857794 no 147 0.0293322239361319 290 893577 SGTC_3014 9081533 49.47 µM 1.88869107888393 0.0312448151860423 no 148 0.029466617354561 230 21367265 SGTC_2987 9018338 71.43 µM 1.88816749131383 0.0312818519580359 no 149 0.0295017342795667 275 5055682 SGTC_1831 st055328 12 µM 1.88034220370981 0.0318397251877818 no 150 0.0300307274799779 262 1103068 SGTC_3245 9134821 49.47 µM 1.87360883208098 0.0323263093031275 no 151 0.0304921799081764 265 17014901 SGTC_819 1013-0258 27.7 µM 1.86672890701171 0.0328298057892804 no 152 0.0309697274084235 294 5753198 SGTC_3079 9117512 49.47 µM 1.86160064206275 0.0332093005015349 no 153 0.0313297013664693 168 7185044 SGTC_271 rotenone 740 µM 1.86094130070021 0.0332583532791185 no 154 0.0313762332664362 297 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_978 1416-0512 87.4 µM 1.85921561538558 0.0333870210046353 no 155 0.0314982911480159 292 6814003 SGTC_595 3909-8003 73.7 µM 1.85721703352343 0.0335365479391221 no 156 0.0316401412754916 261 699517 SGTC_1207 2099-0101 141 µM 1.85327291348376 0.0338332507006255 no 157 0.0319216257363965 286 5837381 SGTC_427 1354-0053 47.3 µM 1.85194589529571 0.0339335619805421 no 158 0.0320167962899956 285 6813657 SGTC_6 0844-0013 19.835 µM 1.85070868178228 0.0340273050143357 no 159 0.0321057372003215 518 1584900 SGTC_3023 9089636 49.47 µM 1.84950637187855 0.0341186073498116 no 160 0.0321923642906137 236 17249241 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.84792108311115 0.0342393005404274 no 161 0.0323068800390202 232 229346 A bile salt which induces apoptosis. SGTC_2100 5377183 190 µM 1.83956167364419 0.0348815470912531 no 162 0.0329163077776312 277 2844202 SGTC_1727 st034309 9.9045 µM 1.83371487480255 0.0353366034524549 no 163 0.0333481647089546 359 870305 SGTC_2141 5621638 7.665 µM 1.82963637712172 0.0356569068308508 no 164 0.0336521651899964 247 2856238 SGTC_307 1501-1223 22.3 µM 1.8246601982922 0.0360509281991153 no 165 0.0340261615329202 249 2830329 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.82212676836009 0.0362528947512432 no 166 0.0342178764686394 271 7104 SGTC_2973 9094665 17.96 µM 1.81965676981186 0.0364506953704273 no 167 0.0344056452801221 328 25237061 YIL048W NEO1 SGTC_1356 1502-0781 85.8 µM 1.81581433444777 0.0367601573131771 no 168 0.0346994288294702 272 567702 SGTC_2795 7780010 54.55 µM 1.81480390844861 0.0368418908082893 no 169 0.0347770247816723 276 953673 SGTC_265 mycophenolic acid 32.932 µM 1.8110968596341 0.0371430280410094 no 170 0.0350629297851458 297 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_823 0417-1665 178 µM 1.80983976914348 0.0372456017043933 no 171 0.0351603193485915 294 3429856 SGTC_1998 st075797 76.8 µM 1.80437827431763 0.037693928540491 no 172 0.0355860132655743 309 24208315 SGTC_2464 5717415 7.67 µM 1.79581799178316 0.0384054859334355 no 173 0.0362617341769515 294 5285744 SGTC_810 3825-7150 143 µM 1.79296836612237 0.0386447708796968 no 174 0.0364889912131809 276 22330411 YGL099W LSG1 SGTC_3210 9128157 49.47 µM 1.79294759661135 0.0386465193580876 no 175 0.0364906518454264 328 17590849 SGTC_2996 9066192 71.4286 µM 1.78886370470374 0.0389915756565554 no 176 0.0368183841686926 316 6472854 SGTC_3241 9133421 49.47 µM 1.78729300706742 0.0391249532372979 no 177 0.0369450718357985 161 17018221 SGTC_1628 st004252 77.7 µM 1.77171300859676 0.040468158692151 no 178 0.0382211045779032 308 692968 SGTC_1174 0739-0097 51.1 µM 1.76797626719741 0.0407958213690098 no 179 0.0385324356583476 311 728447 SGTC_209 4077-0173 175.592 µM 1.76738226755463 0.0408481050044103 no 180 0.0385821152997706 200 15993494 SGTC_2814 7977482 42.97 µM 1.76105636312065 0.0414082877920032 no 181 0.0391144318808935 396 6456762 SGTC_2371 9071574 200 µM 1.75217240278655 0.0422054905312252 no 182 0.0398720837469692 248 45596039 SGTC_1700 st030840 7.9285 µM 1.74997819107527 0.0424042888611236 no 183 0.0400610385152763 304 5499307 SGTC_1087 pterostilbene 9.05 µM 1.74854174326099 0.0425348425713069 no 184 0.0401851319734793 325 5281727 Similar to reservatol, lowers cholesterol. SGTC_1943 st076331 65.2 µM 1.74699554590544 0.0426757340760009 no 185 0.0403190553648892 285 24208415 SGTC_2957 9076800 11.52 µM 1.74504270465268 0.0428542184209145 no 186 0.0404887178434362 290 16459615 SGTC_2457 5731572 11.68 µM 1.73948683449665 0.0433653113490536 no 187 0.0409745830120843 241 2865357 SGTC_724 3910-0327 137 µM 1.7306888172955 0.0441847107583527 no 188 0.0417536404113171 318 2885483 SGTC_1497 4476-2978 41.3 µM 1.72960866791954 0.0442861646112328 no 189 0.0418501081703813 362 1528379 SGTC_95 0471-0001 561.058 µM 1.72497667100975 0.0447233592358241 no 190 0.0422658384190129 324 4015405 SGTC_79 0052-0007 94.094 µM 1.72462358265406 0.0447568278269178 no 191 0.0422976653259881 311 2801472 SGTC_259 usnic acid 108.925 µM 1.72390613066138 0.0448248958977491 no 192 0.0423623952046088 332 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1688 st021091 57.6 µM 1.72129530977317 0.045073300673177 no 193 0.0425986250783735 261 3656366 SGTC_1949 st076024 69.1 µM 1.71933712089241 0.0452603373185536 no 194 0.0427765022249272 343 2921930 SGTC_2952 9073731 13.78 µM 1.71069053014558 0.0460936954223226 no 195 0.0435691283902045 377 16457353 SGTC_2757 clomiphene 4.22 µM 1.70868853214864 0.0462883945491861 no 196 0.0437543297382095 368 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1797 st048695 56.8 µM 1.70632915803075 0.0465186964523946 no 197 0.0439734060975073 346 592262 YIL048W NEO1 SGTC_2411 st077133 39.94 µM 1.70444198800577 0.0467035670484486 no 198 0.0441492726386254 383 1403142 YNL221C POP1 SGTC_2119 5528445 120.635 µM 1.70347295057259 0.0467987245071741 no 199 0.0442397979282081 314 791935 SGTC_260 nsc-65238 3.989 µM 1.7020142373627 0.0469422603115756 no 200 0.0443763496865542 286 3246252 SGTC_2781 5567276 71.43 µM 1.69929570497967 0.0472107029113985 no 201 0.0446317407193632 342 2853274 SGTC_2805 7950783 58.44 µM 1.69615739226655 0.0475221255424284 no 202 0.0449280385414689 385 1178958 YDL195W SEC31 SGTC_282 k297-0036 65.7 µM 1.69587378263906 0.0475503497266103 no 203 0.0449548928366634 271 5061378 SGTC_2013 4024628 200 µM 1.69491031760274 0.0476463318765135 no 204 0.0450462174771904 334 5230760 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.6942654124245 0.0477106651598036 no 205 0.0451074299381115 307 689007 SGTC_1813 st051246 8.6015 µM 1.69126427042587 0.0480109632552127 no 206 0.0453931704003472 261 5291959 SGTC_2782 7736369 71.43 µM 1.6903733353791 0.048100401975084 no 207 0.0454782765197786 370 2950836 YOL077C BRX1 SGTC_2134 5324836 1.464 µM 1.68927316269546 0.0482110294535998 no 208 0.0455835469626725 260 699272 SGTC_338 4055-0136 114 µM 1.68260007917571 0.0488864076076552 no 209 0.0462262681829125 335 2900563 SGTC_1282 0886-0010 32.4 µM 1.68122623575101 0.0490263874260782 no 210 0.0463594896869053 361 2836211 YNL267W PIK1 SGTC_2756 carbadox 75.1 µM 1.67877961026432 0.0492764648532515 no 211 0.0465975019058412 393 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2170 morpholine 200 µM 1.672942638813 0.0498771947269819 no 212 0.0471692943890572 287 121171 Reacts with secondary amines. SGTC_2326 6164455 177.58 µM 1.67223895056203 0.049950009845894 no 213 0.0472386063129544 328 2888790 SGTC_1085 doxorubicin 7.67 µM 1.6716509431527 0.0500109197235239 no 214 0.047296586484879 385 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1464 k208-0027 110 µM 1.66914118374217 0.0502715641490382 no 215 0.0475447015491516 344 X1464 SGTC_311 1315-0136 58 µM 1.66882205140351 0.0503047842415939 no 216 0.0475763255870999 315 6759207 SGTC_1129 3453-1384 223 µM 1.66760121906236 0.0504320283379735 no 217 0.0476974580521776 385 1084452 SGTC_215 1287-0124 461.5 µM 1.66628523988836 0.0505694764097186 no 218 0.0478283075794893 250 5560863 SGTC_1587 estradiol valerate 56.1 µM 1.66482890204735 0.0507219319746525 no 219 0.0479734479984946 343 13791 A steroid. SGTC_99 0109-0120 622.8 µM 1.66441579604318 0.0507652442214374 no 220 0.0480146827723365 295 759414 SGTC_1323 1348-1351 11.2 µM 1.65780487746605 0.0514623829781835 no 221 0.0486784282677843 299 6989654 SGTC_3138 9097216 49.47 µM 1.65635596435163 0.0516161872497873 no 222 0.0488248766222294 328 25237486 SGTC_3121 9125696 49.47 µM 1.65394811825392 0.0518725917639896 no 223 0.0490690273175866 262 1235365 SGTC_866 0495-0101 262 µM 1.65159872618785 0.0521237462921204 no 224 0.0493081899404252 308 635694 SGTC_2933 9026794 32.47 µM 1.64762051257099 0.0525512265480762 no 225 0.0497152842230127 384 17586027 SGTC_3038 9091290 49.47 µM 1.64700163578201 0.0526179775652612 no 226 0.0497788548046818 348 25236843 SGTC_835 0312-0010 67.2 µM 1.64487309192981 0.0528480725727754 no 227 0.0499979924991315 310 1626196 SGTC_2571 chrysanthemic acid 100 µM 1.64375693174517 0.0529690477998244 no 228 0.0501132104193277 326 2743 An insecticide. SGTC_2094 5332512 191.667 µM 1.63532101157018 0.0538904934742911 no 229 0.05099088556499 363 755774 SGTC_618 k072-0232 33.2 µM 1.63414952284426 0.0540194514077724 no 230 0.0511137292261931 314 5872756 YGL099W LSG1 SGTC_983 1491-0821 12.2 µM 1.63120851215267 0.0543442755030539 no 231 0.0514231649069479 307 46495113 SGTC_960 1222-0186 7.7 µM 1.62966359883668 0.0545155236253853 no 232 0.0515863073736298 354 3126296 SGTC_2109 5483026 200 µM 1.62742189779633 0.0547647667669437 no 233 0.0518237619436024 393 759335 SGTC_1151 3909-8316 15.3 µM 1.6243674176281 0.0551058275524142 no 234 0.0521487082917725 355 800431 SGTC_1236 0330-0013 258 µM 1.62190286028504 0.05538223941091 no 235 0.0524120745115749 317 4617066 SGTC_2417 cerulenin 830 nM 1.62113305487764 0.0554688007876356 no 236 0.0524945531250307 320 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1702 st027038 51 µM 1.61495949272735 0.0561668605417409 no 237 0.0531597336357357 382 5521182 SGTC_1114 scopoletin 1.73284 µM 1.61100654653754 0.0566174552721964 no 238 0.0535891477907463 326 5280460 A coumarin with genotoxic properties. SGTC_448 monastrol 171 µM 1.6109183125829 0.0566275454249619 no 239 0.0535987640309272 339 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1490 4089-0339 670 nM 1.60611914530709 0.0571785001665742 no 240 0.0541238670326259 286 742542 SGTC_1834 st055981 52.8 µM 1.60329773823384 0.0575043677851969 no 241 0.0544344678055861 369 471719 YDL150W RPC53 SGTC_3141 9094609 49.47 µM 1.60148960272943 0.0577139712239529 no 242 0.0546342605253679 374 25236309 YDL196W YDL196W SGTC_1626 st003712 1.76 µM 1.59981113390418 0.057909080622422 no 243 0.0548202440500164 343 24207035 SGTC_94 0334-0113 514.748 µM 1.59710843972993 0.0582243376541763 no 244 0.0551207686132514 374 6795178 SGTC_3053 9095903 49.47 µM 1.59349316249389 0.0586481495574636 no 245 0.0555248005019569 321 17174018 SGTC_1975 st070967 30.8 µM 1.59085882238057 0.0589584904663562 no 246 0.0558206756929776 414 261391 SGTC_3028 9087778 49.47 µM 1.58662908815264 0.0594594716451756 no 247 0.0562983376908865 346 17217395 SGTC_1352 1496-0991 99 µM 1.58468131756382 0.0596912901331721 no 248 0.0565193793540198 375 3000039 SGTC_924 2046-0044 21.3 µM 1.58259800265669 0.059940023924348 no 249 0.0567565595238077 370 3623589 SGTC_2893 9048488 25.97 µM 1.57928977240945 0.0603366714931047 no 250 0.057134803345895 360 6467338 SGTC_479 n-linoleoylglycine 10 µM 1.5763436061944 0.0606916352457331 no 251 0.0574733186385327 316 6433346 An anti-infammatory. SGTC_1753 st043925 64 µM 1.575651690094 0.0607752359390945 no 252 0.057553048318216 403 670181 SGTC_303 1348-1668 34.2 µM 1.5690048187062 0.0615829383216087 no 253 0.0583234081056289 344 5380509 SGTC_972 1319-0219 195 µM 1.56831860651843 0.0616667993388742 no 254 0.0584033978637241 388 23903702 SGTC_1465 k213-0056 144 µM 1.56777103500559 0.0617337812170179 no 255 0.0584672884656131 365 24048857 YMR208W ERG12 SGTC_652 0437-0092 114 µM 1.56700096597821 0.0618280762736148 no 256 0.0585572329124426 337 3091274 SGTC_418 lividomycin a 100 µM 1.56526619539328 0.0620409110516574 no 257 0.0587602529961405 380 72394 An antibiotic. SGTC_2022 5136654 200 µM 1.56020996270542 0.0626645099808926 no 258 0.0593551360321267 393 1713771 SGTC_3036 9090181 49.47 µM 1.55871194229479 0.0628501999672219 no 259 0.0595322869758828 331 25236586 SGTC_3293 9120939 62.045 µM 1.55835957989754 0.0628939399426629 no 260 0.0595740163292361 370 934087 SGTC_510 ag-490 170 µM 1.54555858238729 0.0644991095735353 no 261 0.061105605220644 370 5328779 SGTC_1910 st062352 60.4 µM 1.5418991334746 0.0649637841694731 no 262 0.0615490532845745 416 2245730 SGTC_2495 cafestol 54.53 µM 1.54168113365532 0.0649915474542628 no 263 0.0615755493777648 389 16667697 An anti-infammatory. SGTC_3156 9099931 49.47 µM 1.53890151394939 0.065346352745146 no 264 0.0619141707639935 391 18111053 SGTC_2992 9074591 71.4286 µM 1.53529171753162 0.0658093666446976 no 265 0.0623560938526405 378 17741321 SGTC_590 k048-0076 22.4 µM 1.53482138090408 0.0658698815887484 no 266 0.0624138546813407 397 6832814 SGTC_1322 1348-1070 12 µM 1.53196931701915 0.0662377608940457 no 267 0.062765003268107 334 6758089 SGTC_571 k831-0106 44.2 µM 1.53076501302085 0.0663935775179861 no 268 0.0629137397162432 370 4783639 SGTC_895 0964-0006 13.7 µM 1.52679481609903 0.0669092645532118 no 269 0.0634060205265589 388 6738897 SGTC_508 roscovitine 141 µM 1.51911347429081 0.0679157808226226 no 270 0.0643669678294392 362 160355 A CDKinase inhibitor. SGTC_1299 1079-1439 3.74 µM 1.51817318112758 0.0680397901281138 no 271 0.0644853732423955 393 323161 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.51676929110838 0.0682252655401965 no 272 0.064662471436051 374 688803 SGTC_1457 k015-0032 57.3 µM 1.50894640751444 0.069265942088081 no 273 0.0656562394851475 420 4302660 SGTC_1607 st000305 50.6 µM 1.50854303985744 0.0693199317243336 no 274 0.0657077999194417 424 5457690 SGTC_603 3794-0023 45.9 µM 1.50593556626027 0.069669717189167 no 275 0.0660418576185324 382 3802260 SGTC_1560 lithocholic acid 53.1 µM 1.50530762385678 0.0697541566199426 no 276 0.0661225030165629 308 9903 A bile acid which acts as a detergent. SGTC_2381 9035592 200 µM 1.5049380136563 0.069803894929447 no 277 0.0661700069759131 351 4749657 SGTC_3220 9131269 49.47 µM 1.50493724190688 0.0698039988120336 no 278 0.0661701061922554 370 17722206 SGTC_896 0964-0007 44.5 µM 1.50110422673687 0.0703214174488698 no 279 0.0666643028827142 408 6756758 SGTC_3110 9122132 49.47 µM 1.50020978684306 0.0704425812169495 no 280 0.0667800344561964 418 918317 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.49828955540985 0.0707032441622482 no 281 0.0670290182641861 379 364106 SGTC_3223 9129970 49.47 µM 1.49711447164123 0.0708631217889245 no 282 0.0671817374112045 450 17248386 SGTC_2846 9008642 19.48 µM 1.49635926890494 0.0709660184400822 no 283 0.0672800288671217 401 2992898 SGTC_1558 st069300 45.6 µM 1.49608410371157 0.0710035383109623 no 284 0.0673158699006117 328 24208000 SGTC_2549 cedrol 20.94 µM 1.49533500623087 0.0711057579339763 no 285 0.0674135167196975 359 6708665 A sedative which affects the nervous system. SGTC_2913 7966556 36.57 µM 1.49354588807989 0.0713503529247183 no 286 0.0676471759166823 380 2976516 SGTC_2146 5545642 200 µM 1.49083630133323 0.0717220165762761 no 287 0.0680022392299171 411 825326 SGTC_2723 salbutamol 83.58 µM 1.48868483739882 0.0720181809484057 no 288 0.0682851897987903 314 9884233 β2-adrenoceptor agonist SGTC_3307 9126885 69.2785 µM 1.48682174836442 0.0722754052054824 no 289 0.0685309479365329 468 24824909 SGTC_1234 0326-0494 15.5 µM 1.48451647186598 0.0725946531596754 no 290 0.0688359782883794 408 1547813 SGTC_1953 st076800 12.1 µM 1.48030115404839 0.0731812062139467 no 291 0.0693964477059208 471 297591 SGTC_894 0960-0238 55.9 µM 1.47723517022835 0.0736101046467565 no 292 0.0698063046062291 423 6741907 YDL195W SEC31 SGTC_989 1501-0895 10.3 µM 1.47722780442919 0.0736111373525975 no 293 0.0698072914955186 396 2830112 SGTC_1389 3405-0187 19 µM 1.47582765442067 0.07380764358661 no 294 0.0699950824038416 398 799890 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.47562745898722 0.0738357730570058 no 295 0.070021964745165 370 15053 SGTC_1314 1222-0010 41.1 µM 1.4755774497061 0.0738428011424318 no 296 0.0700286812558471 409 3526027 SGTC_1914 st062367 72.6 µM 1.47548175090716 0.0738562516579199 no 297 0.0700415354919474 420 978205 SGTC_2611 pyromycin 23.93 µM 1.47059825877921 0.074545117538045 no 298 0.0706998975658262 444 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2497 7-hydroxyflavone 100 µM 1.4691705216001 0.0747474379620311 no 299 0.070893271845298 398 5281894 SGTC_2059 5238311 157 µM 1.46790431627641 0.0749272185127368 no 300 0.0710651077950584 421 703021 SGTC_848 0368-0089 85.6 µM 1.46560644290133 0.0752543213074287 no 301 0.0713777675026733 451 762535 SGTC_1548 st061468 90.8 µM 1.46354388089016 0.0755488536051796 no 302 0.0716593078173533 428 390799 SGTC_2271 7849410 118.62 µM 1.46245790643676 0.0757042825108291 no 303 0.0718078856121924 413 972430 SGTC_1876 myriocin 605 nM 1.46132851134573 0.0758661842173181 no 304 0.0719626545221365 443 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2162 5663267 200 µM 1.45248454757766 0.0771431188621508 no 305 0.0731834613489902 446 6456493 SGTC_1139 k015-0024 46.9 µM 1.44898140747772 0.0776534110406878 no 306 0.0736713874501106 417 2766652 SGTC_299 1273-0059 1.44 µM 1.44738736133599 0.0778864576973776 no 307 0.0738942317639458 439 2848077 SGTC_2431 5490079 200 µM 1.44597052101143 0.0780940423782954 no 308 0.0740927351437234 460 5722345 SGTC_1132 3456-3614 2.5 µM 1.44453657133402 0.0783045608568324 no 309 0.0742940500906322 560 3125502 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.44330388099536 0.0784858761508721 no 310 0.0744674434995387 442 6708760 SGTC_2031 5180455 200 µM 1.44239931070858 0.0786191309088317 no 311 0.0745948791008881 405 29949 SGTC_2294 7971431 200 µM 1.44206756441466 0.0786680443268944 no 312 0.0746416571159732 376 5741572 SGTC_3295 9122362 53.5725 µM 1.44145322834115 0.0787586843090718 no 313 0.0747283409227129 423 4730473 SGTC_2318 6029776 164 µM 1.44044931262541 0.0789069736874361 no 314 0.0748701603455674 477 818325 SGTC_2033 5192550 145 µM 1.43933030305727 0.0790725128534192 no 315 0.0750284805277986 419 182073 SGTC_3228 9131799 49.47 µM 1.43235907475245 0.0801097201147173 no 316 0.0760205422713359 444 17015818 SGTC_1801 st050089 28.441 µM 1.42325468332327 0.081479753235817 no 317 0.0773311693173729 587 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1143 3454-2408 5.08 µM 1.42179071862012 0.0817016906757593 no 318 0.0775435073981637 386 X1143 SGTC_2652 actinonin 100 µM 1.42148116411907 0.0817486775358006 no 319 0.077588462815214 415 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_739 1486-1183 203 µM 1.42116321673858 0.0817969595420101 no 320 0.0776346576959578 481 4346692 SGTC_3070 9117005 49.47 µM 1.418197770499 0.082248313944391 no 321 0.0780665163259917 375 8779016 SGTC_515 4092-1064 102 µM 1.41812499818676 0.0822594137543437 no 322 0.0780771370391665 530 717353 SGTC_2894 9048625 32.47 µM 1.41578623657951 0.0826167412476496 no 323 0.0784190502468831 443 4092861 SGTC_1238 0333-0287 48.8 µM 1.41222418934847 0.0831632112322252 no 324 0.0789419801086084 470 7226 SGTC_2926 9010726 65.15 µM 1.41034987161931 0.0834518480882518 no 325 0.0792181996709405 494 2994293 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.40702932271047 0.083965045778161 no 326 0.0797093469846422 454 5357218 A potent inhibitor of glutathione S-transferases. SGTC_329 k048-0121 21.3 µM 1.40636366334605 0.0840682093602539 no 327 0.0798080822368589 450 6832902 SGTC_1310 1188-0297 994 nM 1.40017655368692 0.0850316416729481 no 328 0.0807302275645771 488 1588352 SGTC_97 0535-0701 19.132 µM 1.39695154276902 0.0855370971650584 no 329 0.0812140716886794 444 2832013 YGL099W LSG1 SGTC_1227 3909-8010 46.6 µM 1.39627983355888 0.0856426565966157 no 330 0.0813151220801947 455 15982272 SGTC_2043 5101342 149 µM 1.39411166812111 0.0859840503777107 no 331 0.0816419431157523 493 678451 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.39084055364019 0.0865010373128269 no 332 0.0821368912864501 455 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1718 roemerine 11.9335 µM 1.38594088452112 0.087279753200952 no 333 0.0828824776361276 561 235224 An aporphine alkaloid with mutagenic activity. SGTC_3243 9134147 49.47 µM 1.38417544588685 0.0875616174226411 no 334 0.0831523699338395 469 24282180 SGTC_2974 9094440 9.66 µM 1.3823384824623 0.0878556215803947 no 335 0.0834338976369879 534 25236134 SGTC_2218 6965428 192.983 µM 1.38106207062117 0.0880603431431704 no 336 0.0836299382550456 493 675684 SGTC_1640 st009078 66.4 µM 1.37895663648227 0.0883988070853074 no 337 0.0839540621039663 429 690618 SGTC_2197 6588183 93.1375 µM 1.37894779490202 0.0884002304750583 no 338 0.083955425218912 425 884136 SGTC_266 formosanin C 406 nM 1.37781824108878 0.0885822157576999 no 339 0.0841297063376946 517 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.37750412279294 0.0886328737146099 no 340 0.0841782205095109 417 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2383 9036125 200 µM 1.37558919905415 0.0889421608845567 no 341 0.0844744262631267 433 79580 SGTC_3349 9149703 23.001 µM 1.37502741456865 0.0890330492482643 no 342 0.0845614728370366 470 4910494 SGTC_244 nsc-207895 1.295 µM 1.37085858968593 0.0897096639278311 no 343 0.0852095212056303 388 42640 SGTC_2838 9002687 71.43 µM 1.36726789829385 0.0902955035744812 no 344 0.0857706749402501 461 6457060 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.36218814088292 0.0911291384008269 no 345 0.0865692587299746 575 5024745 SGTC_1140 3229-1848 2.98 µM 1.36183241950825 0.0911877286820036 no 346 0.0866253888876817 475 2849525 SGTC_909 3448-9333 149 µM 1.36109582897244 0.0913091400944358 no 347 0.0867417038100702 474 3344074 SGTC_3047 9092122 49.47 µM 1.35453991386589 0.0923950287961538 no 348 0.0877820941852954 497 17173831 SGTC_2437 5741531 144.16 µM 1.35266807333311 0.0927068177809471 no 349 0.0880808471928964 536 2262990 SGTC_1752 st044819 83.042 µM 1.35222053011992 0.0927814793519867 no 350 0.0881523889845729 502 441209 YML126C ERG13 SGTC_342 k048-0088 23.3 µM 1.34965859349532 0.0932097313934814 no 351 0.0885627599679393 507 6820570 SGTC_1387 3342-1166 1.8 µM 1.34730704635882 0.0936040988796685 no 352 0.0889406818239127 428 3418228 SGTC_1759 st043059 70 µM 1.3457562811853 0.0938648441334186 no 353 0.089190564505968 536 669426 SGTC_1055 3448-0672 86 µM 1.33885740835838 0.0950313180071751 no 354 0.0903085487301635 511 748378 SGTC_689 0833-0039 98 µM 1.33881514754758 0.0950384962976379 no 355 0.0903154291548339 536 5374726 SGTC_3182 9108849 49.47 µM 1.33812379482008 0.095155984046852 no 356 0.0904280426290423 548 17133045 SGTC_2882 9058044 58.44 µM 1.33684627363909 0.095373366014052 no 357 0.0906364105387757 490 18076804 SGTC_2684 capsaicin 100 µM 1.33406936201379 0.0958471436031933 no 358 0.0910905628322263 487 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_774 k060-0086 136 µM 1.33139817881896 0.0963045138927407 no 359 0.0915290141753276 596 5911235 SGTC_745 0469-0705 296 µM 1.32758730476865 0.0969598001624994 no 360 0.0921572403845333 598 3486736 SGTC_648 0375-0473 33.3 µM 1.3266839415346 0.0971156138244144 no 361 0.0923066276059926 569 1713139 SGTC_3192 9110362 49.47 µM 1.32620155414616 0.0971988920680671 no 362 0.0923864723296428 535 16649480 SGTC_2414 st077232 92.9 µM 1.32585485381046 0.0972587779708551 no 363 0.0924438897009007 515 729801 SGTC_249 wiskostatin 11.211 µM 1.32529218929052 0.0973560252011453 no 364 0.0925371292956152 529 2775510 A n-wasp and actin depolymerizer. SGTC_3184 9108758 49.47 µM 1.32477868725843 0.0974448377505058 no 365 0.0926222828377876 503 902885 SGTC_3051 9093778 49.47 µM 1.32372826552721 0.0976266981349466 no 366 0.0927966537793087 436 17217378 SGTC_1579 chlormadinone acetate 49.4 µM 1.32354843351508 0.0976578575348016 no 367 0.0928265303736775 533 45114258 A steroidal progestin. SGTC_2106 5357045 167.29 µM 1.32049594891425 0.098187872807981 no 368 0.0933347438464284 545 668842 SGTC_2529 gangaleoidin 93.61 µM 1.31752719238151 0.0987053683828842 no 369 0.093830986210688 513 4565183 SGTC_962 1254-0300 21.5 µM 1.31708407650376 0.098782780541991 no 370 0.0939052219515111 528 7340576 SGTC_1907 st060210 83.7 µM 1.31603080644635 0.0989669646761812 no 371 0.0940818515182726 583 688793 SGTC_928 2764-0428 58.7 µM 1.31382803354151 0.0993529729371199 no 372 0.0944520407016511 570 662578 SGTC_3123 9126162 49.47 µM 1.31333154448094 0.0994401282001407 no 373 0.0945356267811743 523 25239884 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.31212295291506 0.0996525217648766 no 374 0.0947393263204717 561 5393153 SGTC_53 0973-0023 39.979 µM 1.31151976351651 0.099758648030278 no 375 0.09484111054034 510 674768 SGTC_2677 mitomycin C 100 µM 1.30835699814992 0.100316462525906 no 376 0.0953761254014599 473 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_963 1269-2853 151 µM 1.30830931813044 0.100324889196627 no 377 0.0953842079405894 528 3668223 SGTC_1715 st032160 10.2275 µM 1.30746389703034 0.100474389472391 no 378 0.0955276043150802 522 5289825 SGTC_3146 9095609 49.47 µM 1.29553748989877 0.102600744354511 no 379 0.0975674386169405 537 17173999 SGTC_749 1000-0129 128 µM 1.28578645516246 0.104363411031536 no 380 0.099258799307066 599 708470 SGTC_224 benfluorex 43.875 µM 1.28572765467393 0.10437410638037 no 381 0.099269063136692 446 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2073 5212005 126 µM 1.28428331472167 0.104637069939346 no 382 0.0995214213832489 454 691789 SGTC_373 0844-0104 25.9 µM 1.28368746885731 0.104745692240524 no 383 0.0996256653775089 602 5375804 SGTC_585 0kpi-0023 191 µM 1.28308758579914 0.104855132986583 no 384 0.0997306962611709 510 64601 SGTC_2873 9040596 71.43 µM 1.28262837230562 0.104938966356924 no 385 0.0998111525792567 568 6463863 SGTC_3239 9133757 49.47 µM 1.27903605156726 0.105596450307407 no 386 0.100442180399998 541 17036923 SGTC_504 lovastatin 124 µM 1.27479177582605 0.106377090671664 no 387 0.101191476204536 485 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2922 7999257 32.47 µM 1.27340652613428 0.106632776420849 no 388 0.101436911384247 509 2988377 SGTC_131 0141-0277 33.849 µM 1.2726490188135 0.106772782596277 no 389 0.101571307943722 576 1547771 SGTC_2195 6536160 144.242 µM 1.26762746455555 0.107704245743814 no 390 0.102465509596854 499 3834386 SGTC_40 0327-0103 19.753 µM 1.26602267777869 0.108003153215562 no 391 0.102752481648117 563 409036 SGTC_2969 9091408 28.7 µM 1.2630466432274 0.108559049236467 no 392 0.103286208790962 554 4286311 SGTC_3033 9090887 49.47 µM 1.26302680329888 0.108562762046988 no 393 0.103289773659167 598 19325384 SGTC_400 oxethazaine 37.5 µM 1.25946123674481 0.10923150014481 no 394 0.103931891463126 558 4621 A local anesthetic. SGTC_2078 5212016 200 µM 1.25678050867609 0.109736228302473 no 395 0.104416562933233 519 1899708 SGTC_2484 5809818 12.04 µM 1.25643755706548 0.109800919912613 no 396 0.104478686020728 571 2870548 SGTC_2945 9067681 61.76 µM 1.25499420647549 0.110073481883323 no 397 0.104740431562541 549 16456930 SGTC_2791 5663188 71.43 µM 1.2544182341409 0.110182383744085 no 398 0.104845014169298 536 54690634 SGTC_2074 5212007 75.395 µM 1.25381408949746 0.110296695300425 no 399 0.104954793410048 489 758611 SGTC_2393 9031399 185.94 µM 1.24931336060201 0.111150965760205 no 400 0.105775241551826 570 1526623 YDL150W RPC53 SGTC_2007 4011539 71.82 µM 1.24817361490779 0.111368047438481 no 401 0.105983742124782 590 45595301 SGTC_509 pifithrin 175 µM 1.24707613478131 0.111577365639798 no 402 0.106184791317369 576 4817 A p53 inhibitor. SGTC_529 4076-0302 30.3 µM 1.24623226818974 0.111738504426073 no 403 0.10633956788061 582 5816522 SGTC_852 0418-0143 439 µM 1.24235381463648 0.112481247112009 no 404 0.107053024052705 671 5369229 SGTC_1855 st056195 39.6 µM 1.24114044826978 0.11271433533171 no 405 0.107276934778689 578 4028379 SGTC_2460 5552655 174.22 µM 1.24104265577168 0.11273313632241 no 406 0.107294995784051 581 5401989 SGTC_2412 st077135 33.4 µM 1.23712258361946 0.113488630355858 no 407 0.108020788369575 609 13258915 SGTC_2597 laccaic acid a 100 µM 1.23464666038512 0.113967657870353 no 408 0.108481017664024 618 5491415 A textile dye. SGTC_1819 st053448 58.6 µM 1.23298885882126 0.11428920402782 no 409 0.108789960430858 581 2857616 SGTC_2904 7225135 42.03 µM 1.23169668758034 0.114540280369101 no 410 0.109031203826077 614 4446116 SGTC_65 0798-0905 34.986 µM 1.2312425117653 0.114628622531239 no 411 0.109116087957318 705 3602145 SGTC_107 0358-0022 2.6945 µM 1.22975748311132 0.11491781528262 no 412 0.109393966949456 434 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2807 7945238 51.95 µM 1.22696194241785 0.115463622786994 no 413 0.109918447663853 613 17148797 SGTC_2116 5511452 16.8835 µM 1.22486557284268 0.115874129462464 no 414 0.110312936816022 612 870744 SGTC_2892 9047358 58.44 µM 1.22412248332232 0.116019888166587 no 415 0.11045301282385 547 6466771 SGTC_2219 9098279 200 µM 1.22208670609197 0.116419877113762 no 416 0.110837419899523 571 902349 SGTC_481 bay k-8644 50 µM 1.22187100009876 0.116462316214826 no 417 0.110878206827891 566 2303 A calcium channel antagonist. SGTC_1643 st009866 20.2 µM 1.22058688599802 0.116715186511382 no 418 0.111121237043262 579 3156273 YOR207C RET1 SGTC_633 0437-0093 97.7 µM 1.21971028938153 0.116888031077487 no 419 0.111287359818124 578 2831118 SGTC_647 0140-0236 81 µM 1.21941846189745 0.1169456129365 no 420 0.111342703120954 681 990837 SGTC_832 4083-0019 164 µM 1.21776029641278 0.117273175042675 no 421 0.111657538099961 816 1990758 SGTC_2830 7992007 71.43 µM 1.21264779132088 0.118287213280293 no 422 0.112632254296531 578 1952075 SGTC_1755 st041960 45.185 µM 1.21215667368731 0.118384949220199 no 423 0.112726206442151 600 2257073 SGTC_922 1866-0035 480 µM 1.21199189019354 0.118417755106724 no 424 0.112757742509566 709 3156169 SGTC_29 0299-0004 12.984 µM 1.21016119285764 0.118782651396236 no 425 0.113108522973312 508 16871 A napthoquinone isolated from Swertia calycina. SGTC_2622 2-methoxyxanthone 59.94 µM 1.20514569814068 0.119786411013673 no 426 0.114073530468221 665 71034 A hepatoprotective. SGTC_2081 5214970 32.255 µM 1.20370098537559 0.120076650219396 no 427 0.114352585641289 600 2063512 SGTC_2990 9074105 71.4286 µM 1.2008488019484 0.12065110102428 no 428 0.114904928653694 572 6502001 SGTC_833 3852-0053 558 µM 1.19713759279693 0.121401458763699 no 429 0.115626464740686 700 3123681 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.19503481601697 0.121828065857723 no 430 0.116036713812874 594 6708514 SGTC_105 0111-0055 734.78 µM 1.19334822250415 0.122170998842688 no 431 0.116366512004145 539 5179370 SGTC_1860 st056228 74.6 µM 1.1933428270148 0.122172096987354 no 432 0.116367568109548 594 688679 SGTC_1211 1056-0033 32.3 µM 1.1924857130686 0.122346633506412 no 433 0.116535424722571 651 6741922 SGTC_148 3253-0744 288.01 µM 1.19140854107346 0.122566229141243 no 434 0.116746620777648 605 6893655 SGTC_2145 5634607 200 µM 1.18822612431935 0.123216621369053 no 435 0.117372166967776 555 308662 SGTC_757 1066-0008 322 µM 1.18771152344696 0.123322017370944 no 436 0.117473541115294 663 6842497 SGTC_1766 st045414 44.774 µM 1.18563013686194 0.123748952917912 no 437 0.117884197693439 666 253960 SGTC_1611 st001856 99.4 µM 1.18503711978298 0.123870782205167 no 438 0.118001385375181 600 647478 SGTC_809 3998-0021 90 µM 1.18385766951225 0.124113337658749 no 439 0.118234704560796 611 715485 SGTC_578 3460-0051 92 µM 1.18380534260144 0.124124106447766 no 440 0.118245063436781 701 2876744 SGTC_990 3985-0011 41.3 µM 1.18283886375439 0.124323123694548 no 441 0.118436507428558 574 5399565 YGL099W LSG1 SGTC_447 ml7 120 µM 1.18230674697115 0.124432792351168 no 442 0.118542004715261 643 4216 Selective myosin light chain kinase inhibitor. SGTC_2575 plumbagin 510 nM 1.18035034074162 0.124836586911975 no 443 0.118930452002745 614 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3167 9103034 49.47 µM 1.17958904763662 0.124993962006765 no 444 0.119081850539784 571 5127859 SGTC_1929 genistein trimethyl ether 50.5 µM 1.17678461236569 0.125574892365842 no 445 0.119640742934751 635 136420 SGTC_2051 5263410 176 µM 1.17391220659884 0.126171852962627 no 446 0.120215096319642 663 227584 SGTC_3005 9076496 71.4286 µM 1.17368107457992 0.126219974050056 no 447 0.120261396749658 609 21368410 SGTC_2225 6654152 15.4 µM 1.16904167783284 0.127188590498564 no 448 0.12119341993283 570 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_34 0469-0683 81.75 µM 1.16790333889968 0.127427041751574 no 449 0.121422878594024 642 3690923 SGTC_1181 1222-0449 220 µM 1.16505742801775 0.128024542855821 no 450 0.121997873861754 669 658318 SGTC_3037 9091026 49.47 µM 1.16482312711604 0.128073821075823 no 451 0.122045297686608 753 25236398 YIL048W NEO1 SGTC_1808 st050063 61.5 µM 1.16438609602168 0.128165772761757 no 452 0.122133789838217 633 4011993 SGTC_2833 9001315 45.46 µM 1.16411406733084 0.128223030958683 no 453 0.122188894255604 659 2989378 SGTC_3022 9087993 49.47 µM 1.16388599564681 0.128271050514901 no 454 0.122235107822656 621 17173644 SGTC_2091 4-phenylthiadiazole 200 µM 1.16331236323413 0.128391881659221 no 455 0.122351395691114 664 270010 SGTC_2768 sulfasalazine 50.2 µM 1.16164305388427 0.128743957986288 no 456 0.122690242987599 654 5384001 An antioxidant and salicylic acid derivative. SGTC_2222 6885208 172.143 µM 1.1602745144819 0.129033097747564 no 457 0.122968528654564 610 609514 SGTC_2635 hydroquinidine 100 µM 1.1593104361381 0.129237054662801 no 458 0.123164834670621 655 442912 An experimental heart treatment. SGTC_2649 anisomycin 9.56 µM 1.15719129535711 0.129686157541739 no 459 0.123597106657864 621 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_947 3447-0010 211 µM 1.15708632898976 0.129708430796881 no 460 0.123618545757474 648 748350 SGTC_2285 7945142 200 µM 1.15082812981777 0.131041174212104 no 461 0.124901474873928 624 2970608 SGTC_2242 6630449 61.2675 µM 1.14801625163086 0.131643060420743 no 462 0.125480927447578 576 691249 YDR170C SEC7 SGTC_588 3970-1144 52.9 µM 1.14399780345589 0.132506521573523 no 463 0.126312273972123 683 1888707 SGTC_3345 9148410 3.559 µM 1.14263587428927 0.13280004855338 no 464 0.1265949021775 638 4903596 SGTC_522 1273-0010 11.6 µM 1.14213540838578 0.132908022855688 no 465 0.126698869689399 639 5705015 SGTC_1301 naphtanilide LB 4.81 µM 1.14175131929685 0.132990930127595 no 466 0.126778701230132 704 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_301 4119-0100 24.5 µM 1.14139428090639 0.133068030313992 no 467 0.126852941784208 715 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_520 3584-0023 682 µM 1.13745158324501 0.13392147686554 no 468 0.127674776915353 633 1340790 SGTC_1109 tnp00067 928.257 nM 1.13524306763307 0.134401178103724 no 469 0.12813674453626 676 676295 SGTC_1209 2323-2347 50.3 µM 1.13311625047019 0.134864247895044 no 470 0.128582718968107 666 5412760 SGTC_2521 angolensin 13.4 µM 1.1322811398642 0.135046374620765 no 471 0.12875812833584 631 821428 A flavenoid. SGTC_3196 9111891 49.47 µM 1.13150416373995 0.135215974380457 no 472 0.128921475962381 649 18891510 SGTC_1932 st074806 40.9 µM 1.12712689917033 0.13617417988318 no 473 0.129844415921445 732 17251235 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.12393129805847 0.136876641152524 no 474 0.130521086249961 727 6708561 SGTC_3331 9141060 1.957 µM 1.12302113967652 0.137077165734126 no 475 0.130714258194982 639 4906567 YPR165W RHO1 SGTC_1896 st058441 89 µM 1.12279723883013 0.13712652594175 no 476 0.130761809167793 624 688759 SGTC_2735 sertaconazole 140 nM 1.11847101889426 0.138082649887788 no 477 0.13168293871587 635 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_703 3875-0075 71.8 µM 1.11726271748081 0.138350502966037 no 478 0.131941005699141 738 2850814 SGTC_2864 9034755 47.6 µM 1.11639849805917 0.138542297952361 no 479 0.132125798068693 670 4930451 SGTC_2937 9044753 11.33 µM 1.10744757431667 0.140539418926843 no 480 0.134050233370663 725 6465530 YGL099W LSG1 SGTC_82 0054-0107 293.755 µM 1.106202588981 0.140818739216039 no 481 0.134319421265853 687 3104697 SGTC_690 glyoxal 20.3 µM 1.10583267805673 0.140901803589988 no 482 0.134399474048218 708 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2486 5283202 22.39 µM 1.10537159837646 0.141005386650854 no 483 0.134499302606255 659 1377751 SGTC_285 1486-1325 46 µM 1.10017273673038 0.142176902152336 no 484 0.135628433448725 749 22310230 SGTC_1318 1280-3875 124 µM 1.09903410362941 0.142434359413185 no 485 0.135876595365907 727 373245 SGTC_2686 alizarin 95.37 µM 1.09899368256402 0.142443504845828 no 486 0.135885410735721 647 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1739 st037196 92.5 µM 1.09736962346756 0.142811283505173 no 487 0.136239923349574 759 612214 SGTC_2299 7976368 114.88 µM 1.0959339626788 0.143136932192261 no 488 0.136553837458094 704 2979718 SGTC_1219 1469-0211 33.1 µM 1.09278974281073 0.143851881809985 no 489 0.137243063093279 683 6822282 SGTC_1300 1094-0077 113 µM 1.0918483251201 0.144066414268598 no 490 0.1374498870454 675 5532636 SGTC_2216 7189485 200 µM 1.0901532788255 0.144453229076798 no 491 0.137822815073367 741 731273 SGTC_2023 5144124 124 µM 1.08962180782355 0.144574656389947 no 492 0.137939886317988 710 2830192 SGTC_1675 st018485 24.5 µM 1.08579473264092 0.1454510737614 no 493 0.13878490866107 715 3323024 SGTC_912 3474-0017 2.18 µM 1.08470492685259 0.145701296469819 no 494 0.13902618252728 734 3360550 SGTC_414 piperonyl butoxide 100 µM 1.08359142625794 0.14595725830047 no 495 0.139272996982827 698 5794 A potent inhibitor of cytochrome P450. SGTC_1785 bathophenanthroline 24 µM 1.08349175935104 0.14598018358554 no 496 0.139295103312327 705 72812 An iron chelator. SGTC_2496 diffractaic acid 79.83 µM 1.08123876084309 0.146499061637407 no 497 0.139795460141944 761 94870 An apoptosis inducer which activates caspases. SGTC_2824 7998404 51.95 µM 1.07979724138366 0.14683170023751 no 498 0.140116239947051 675 837851 SGTC_1895 st058434 18.3 µM 1.07784035949192 0.147284071730128 no 499 0.140552502437598 750 5393175 SGTC_2340 7987427 183.45 µM 1.07619712455165 0.147664658402726 no 500 0.140919552739829 714 2239331 SGTC_2312 7706453 155.7 µM 1.07449612570722 0.14805931689024 no 501 0.141300190140086 704 976098 SGTC_3229 9132204 49.47 µM 1.07358160218221 0.148271792260891 no 502 0.141505123514503 698 17682924 SGTC_1419 3993-2473 62.6 µM 1.07241709840164 0.148542641775055 no 503 0.141766365730686 738 704026 SGTC_555 4296-0685 37 µM 1.07223933801752 0.148584015778807 no 504 0.141806272822587 751 2908540 YHR072W ERG7 SGTC_269 exalamide 29 µM 1.07171943309879 0.148705068668777 no 505 0.141923034803697 707 3316 A derivative of salicylamide. SGTC_1116 jasmonic acid  1.58368 µM 1.07089440792928 0.148897299991236 no 506 0.142108455282859 753 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1555 citronellol 128 µM 1.06976590387232 0.149160510842318 no 507 0.142362346613782 702 8842 A terpine precursor. SGTC_1286 0929-0070 131 µM 1.06771194671335 0.149640370225812 no 508 0.142825233898762 760 1420408 SGTC_1625 st003711 30.1 µM 1.06769784960295 0.149643667243287 no 509 0.142828414386088 730 24207034 YER133W GLC7 SGTC_2293 7624732 200 µM 1.0652229215962 0.150223252093309 no 510 0.143387531641961 662 894453 SGTC_1012 4112-3522 18 µM 1.05991222078885 0.151471968790454 no 511 0.144592267697739 754 3112398 SGTC_3062 9077494 49.47 µM 1.05977519422084 0.151504279217828 no 512 0.144623442244685 718 16459633 SGTC_2385 9074692 200 µM 1.05874290326024 0.151747837413903 no 513 0.144858441524827 740 17046906 SGTC_375 3970-0961 9.27 µM 1.05596557311316 0.152404410349725 no 514 0.145491971856856 754 2898222 SGTC_3259 9138485 49.47 µM 1.05348212877796 0.152993101818787 no 515 0.146060040359818 814 17646153 SGTC_1425 4048-4433 7.33 µM 1.05270714150786 0.153177117948402 no 516 0.146237617288808 800 23734946 SGTC_2066 5222451 176 µM 1.05045017381397 0.153713856808664 no 517 0.14675559391373 807 2281147 SGTC_2930 9013230 14.89 µM 1.04942565555909 0.153957912137813 no 518 0.146991127717781 805 2995857 SGTC_1121 fusaric acid 630.51 nM 1.04801106381472 0.154295309920109 no 519 0.147316754740637 756 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_441 propafenone 146 µM 1.04767147864959 0.154376377941951 no 520 0.147394996269995 697 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1501 4491-0275 38.4 µM 1.04648108495651 0.154660778966725 no 521 0.147669486719617 773 5104718 SGTC_3172 9105863 49.47 µM 1.04487603720454 0.155044794202494 no 522 0.148040133093307 699 2348785 SGTC_1167 k781-0610 148 µM 1.04468565494886 0.155090385787721 no 523 0.148084138472542 809 4525169 SGTC_744 1594-0068 283 µM 1.04277406996842 0.155548651137839 no 524 0.14852647168709 809 668392 SGTC_2405 ticlatone 3.52 µM 1.03955289712693 0.156322883525424 no 525 0.149273835136417 724 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3067 9117431 49.47 µM 1.03910438310792 0.156430888120895 no 526 0.149378096347467 711 17150885 SGTC_2718 lomofungin 53.02 µM 1.03788184987686 0.156725530183817 no 527 0.149662532241325 741 5351222 A RNA synthesis inhibitor. SGTC_2260 7964312 200 µM 1.03732352496388 0.156860213182543 no 528 0.149792552837961 712 231951 SGTC_1253 0550-0034 176 µM 1.03713426519157 0.156905885012218 no 529 0.149836644033045 702 5969915 SGTC_2719 novobiocin 32.65 µM 1.03707701876057 0.156919701341787 no 530 0.1498499822412 709 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.03573193597114 0.157244565147398 no 531 0.150163609496474 731 4330530 SGTC_248 streptozotocin 5.23457 mM 1.03530306797516 0.157348238063955 no 532 0.150263698756569 806 5300 DNA alkylating agent. SGTC_2514 salinomycin 42.74 µM 1.03425660648942 0.157601394216317 no 533 0.150508108612257 857 23682228 A polyether potassium ionophore. SGTC_1061 3448-9325 110 µM 1.03342797253797 0.157802044071051 no 534 0.150701830784785 742 723482 SGTC_41 0478-0632 82.643 µM 1.03313522522621 0.1578729715601 no 535 0.150770310382372 854 3750424 SGTC_2564 betulinic acid 100 µM 1.03131990760848 0.158313258205323 no 536 0.151195412887651 827 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_707 0865-0008 204 µM 1.02630751855453 0.159533141100114 no 537 0.15237332721855 822 723043 SGTC_172 1112-0046 2.638 µM 1.02285140939755 0.160377840883189 no 538 0.153189053342947 697 2802135 YIL048W NEO1 SGTC_678 1218-2179 85.9 µM 1.01960436126478 0.161174102455506 no 539 0.153958067888727 742 6820081 YOR116C RPO31 SGTC_3189 9110682 49.47 µM 1.01879619147579 0.161372687131841 no 540 0.154149867097565 769 17122418 SGTC_1266 0828-0227 32.9 µM 1.01724642768709 0.161753943589724 no 541 0.154518107348506 743 3913820 SGTC_1571 st070080 73.4 µM 1.01595482032803 0.162072139249486 no 542 0.15482545077986 775 4315245 SGTC_315 k915-0449 187 µM 1.01558477586662 0.162163377125223 no 543 0.154913578796332 871 20970215 YNL149C PGA2 SGTC_2733 amorolfine 100 µM 1.01546406588114 0.162193146518656 no 544 0.154942333673587 724 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2569 tetrandrine 100 µM 1.01130709878931 0.163220505240773 no 545 0.155934734753352 697 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_51 1013-0126 23.419 µM 1.00901950367829 0.163787664532987 no 546 0.156482640292648 757 1627850 SGTC_3030 9087619 49.47 µM 1.00471000374061 0.164859581326927 no 547 0.157518254859578 798 25236973 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.00428731152495 0.164964963155322 no 548 0.157620073885516 790 5379071 SGTC_2724 maprotiline 69.64 µM 1.00150811661993 0.165658933034032 no 549 0.158290609031181 825 4011 A tricyclic antidepressant. SGTC_531 3788-1495 174 µM 1.00092093612979 0.165805794247552 no 550 0.158432516959392 759 2896655 SGTC_980 1473-0395 201 µM 1.00034352719015 0.165950293523903 no 551 0.15857214468596 722 768876 SGTC_1347 1493-0251 600 nM 0.99982606175611 0.166079860786938 no 552 0.158697345554706 872 3986378 SGTC_1142 3253-1408 9.78 µM 0.99790033205276 0.166562614903466 no 553 0.15916384548224 799 256655 SGTC_2766 oltipraz 83.91 µM 0.991887253766893 0.168075834527066 no 554 0.16062626377925 781 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2307 7538926 6.34 µM 0.991795216235615 0.16809906473704 no 555 0.1606487158622 813 96582 SGTC_2198 6589944 200 µM 0.989335836808628 0.16872057554429 no 556 0.161249427948819 726 5290268 SGTC_2446 5162541 200 µM 0.989057267839255 0.168791065817982 no 557 0.161317561667929 764 1549321 SGTC_2714 st079313 56.9 µM 0.989045105820446 0.168794143777888 no 558 0.161320536739883 800 2939799 SGTC_2281 7943571 200 µM 0.988599853242379 0.168906852990037 no 559 0.161429479023175 890 1244024 SGTC_2193 5925765 200 µM 0.987629597844878 0.169152626455959 no 560 0.161667042638994 784 877370 SGTC_309 k408-0051 1.48 µM 0.985539628754335 0.169682811985222 no 561 0.162179537876337 863 3640463 SGTC_3205 9113483 49.47 µM 0.985470985428596 0.169700243555432 no 562 0.162196388286821 820 17018033 SGTC_1453 4237-0541 195 µM 0.984362170651596 0.16998197968219 no 563 0.162468735586198 849 739892 SGTC_2655 perillic acid 100 µM 0.979266715782831 0.171280523799791 no 564 0.163724105859456 778 5702197 An apoptosis inducer. SGTC_181 1447-1644 8.07 µM 0.979007698216388 0.171346701725959 no 565 0.163788087905607 821 534600 SGTC_3169 9102970 49.47 µM 0.978037352018381 0.171594766490903 no 566 0.164027925309995 843 17027839 SGTC_2939 9044578 71.43 µM 0.977652171412429 0.171693299817703 no 567 0.164123192322609 782 2653634 SGTC_3238 9133470 49.47 µM 0.977232617704716 0.171800667268815 no 568 0.164227001688286 820 3534688 SGTC_69 0096-0274 206.684 µM 0.974343388041221 0.172541210365101 no 569 0.164943034168982 892 6741392 SGTC_1638 st008370 60.6 µM 0.971163888068499 0.173358502023982 no 570 0.165733336718413 803 24207134 SGTC_3274 9138298 49.47 µM 0.97109613442336 0.173375944900413 no 571 0.16575020429069 890 17015756 SGTC_2964 9083345 53.42 µM 0.969410970992532 0.173810142213209 no 572 0.16617009031815 777 17741579 SGTC_770 0389-1121 67.2 µM 0.966100300121117 0.17466517804982 no 573 0.1669969971914 887 6753108 SGTC_2849 9019321 12.99 µM 0.963958392698713 0.175219781629076 no 574 0.16753339317509 769 16489627 SGTC_2356 9061756 188.97 µM 0.96376713360895 0.175269358556098 no 575 0.167581343939995 841 20104043 SGTC_420 mitomycin C 81.9 mM 0.960750689973337 0.176052437451312 no 576 0.168338768653554 827 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_587 k089-0003 57 µM 0.959864055275 0.176283031371168 no 577 0.168561819419881 734 9659696 SGTC_3339 9145883 14.936 µM 0.959201067106044 0.176455584646971 no 578 0.168728731505881 802 2030670 SGTC_1658 st012944 20 µM 0.957461417918457 0.176908863954827 no 579 0.169167205641746 813 24207260 SGTC_2409 alverine citrate 63.97 µM 0.957074414013943 0.177009800844292 no 580 0.169264848382681 826 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2196 6573537 42.6665 µM 0.956546504327817 0.177147546905524 no 581 0.169398100580717 858 2903087 SGTC_350 k064-0020 19.8 µM 0.955942957249995 0.177305111760937 no 582 0.16955052723402 899 2790705 SGTC_1512 0259-0544 12.2 µM 0.955474864496259 0.177427375183845 no 583 0.1696688052798 883 18476 SGTC_1025 k007-0731 70 µM 0.954580698455741 0.177661074661631 no 584 0.169894890931602 829 6256118 SGTC_1267 0828-0272 9.49 µM 0.95191275187845 0.17835952357935 no 585 0.170570615914695 879 745334 SGTC_845 0330-0138 4.51 µM 0.95035183510799 0.178768961278497 no 586 0.170966754351581 867 9039800 SGTC_1046 2001-0062 216 µM 0.949966037742729 0.178870249332634 no 587 0.171064754866714 825 739778 SGTC_1469 k284-2957 126 µM 0.949624392612365 0.178959975716011 no 588 0.171151569792137 845 23884841 SGTC_2452 5863136 48.41 µM 0.949522311903259 0.178986790704151 no 589 0.171177514832207 833 2184096 SGTC_1883 5-benzylidenerhodanine 20 µM 0.947242688842887 0.179586270170464 no 590 0.171757563578531 897 1273210 SGTC_839 0122-0028 230 µM 0.947216305447454 0.17959321567121 no 591 0.171764284158516 898 759448 SGTC_433 pimozide 108 µM 0.947037394732887 0.17964031885805 no 592 0.171809862093235 730 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1840 st055363 71 µM 0.946806069348294 0.179701233161109 no 593 0.171868804239671 800 676033 SGTC_3107 9121808 49.47 µM 0.945859848814469 0.179950534009414 no 594 0.172110037437743 831 662681 SGTC_726 3448-4391 34.2 µM 0.945412329471374 0.180068517605223 no 595 0.172224205023673 893 1356692 SGTC_1487 3970-0795 2.82 µM 0.944932816513724 0.180194989853413 no 596 0.172346588184616 882 3765103 SGTC_1633 st005664 67.9 µM 0.942772445502218 0.18076548208565 no 597 0.172898654293488 869 2063822 SGTC_1976 st070609 63.5 µM 0.941596908433877 0.181076382983595 no 598 0.173199526580528 878 682556 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.94056225746661 0.181350299952084 no 599 0.173464615546449 902 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2171 5739187 198.077 µM 0.938646748545555 0.18185810257793 no 600 0.173956071224826 809 2262761 SGTC_2174 5790901 200 µM 0.938037102189709 0.182019906604151 no 601 0.174112671685462 846 786020 SGTC_1016 4226-1401 38 µM 0.938019556562847 0.182024564657453 no 602 0.174117179974138 855 2901613 SGTC_31 0508-1974 57.237 µM 0.936288278411358 0.182484554823832 no 603 0.174562390806097 843 6810525 SGTC_2726 cimetidine 79.27 µM 0.936017578756593 0.18255654367616 no 604 0.174632068499888 843 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1374 2889-5571 141 µM 0.93544268228605 0.18270948831294 no 605 0.174780104575746 877 2853281 SGTC_1661 st013063 9.66 µM 0.934727964260311 0.182899742393713 no 606 0.174964255797704 930 721395 SGTC_1339 1486-1321 22.7 µM 0.934505401603687 0.182959012607836 no 607 0.175021625478766 865 3469382 SGTC_1378 2093-0007 380 nM 0.933824285421669 0.183140473744751 no 608 0.175197270034546 848 3618014 SGTC_2016 5121758 140 µM 0.933360725037056 0.18326403843321 no 609 0.175316875751249 933 2795203 SGTC_608 k048-0125 159 µM 0.93306426999555 0.183343087479866 no 610 0.175393392852364 891 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_499 genistein 192 µM 0.933056045852837 0.183345280731402 no 611 0.175395515862377 868 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3035 9091303 49.47 µM 0.932771962181296 0.183421051490382 no 612 0.175468860251698 889 25237002 SGTC_3320 9137005 35.139 µM 0.932758674366567 0.183424596092386 no 613 0.175472291359992 824 4908713 SGTC_2895 9054447 58.44 µM 0.931874822092661 0.183660464716144 no 614 0.175700610443746 848 2697450 SGTC_1407 3909-7909 12.3 µM 0.931455333721004 0.183772477292931 no 615 0.175809039636991 912 4411780 SGTC_2136 5328288 199.296 µM 0.930087550004634 0.184138000993938 no 616 0.176162878174905 764 262395 SGTC_3066 9117245 49.47 µM 0.927651445320644 0.184790140438531 no 617 0.176794201266565 925 17176980 SGTC_3276 9139060 49.47 µM 0.926224744729204 0.185172730548418 no 618 0.177164597790284 854 4870619 SGTC_1262 0737-0114 49.6 µM 0.926108365090718 0.185203961095835 no 619 0.177194833595217 946 765919 SGTC_1852 st056254 31.4 µM 0.924947203502222 0.185515738634153 no 620 0.177496685577231 859 442583 SGTC_2168 5727979 200 µM 0.924911393727035 0.185525358908008 no 621 0.177505999732074 813 695210 SGTC_2282 7944268 200 µM 0.924173607174052 0.185723633704063 no 622 0.177697967331558 883 2970414 SGTC_1330 1469-0054 61.8 µM 0.918337088011515 0.187296785550839 no 623 0.179221208069476 942 7102664 SGTC_2178 5812956 200 µM 0.916238366720395 0.187864474401278 no 624 0.179770943199011 902 5403383 SGTC_1057 3448-5381 134 µM 0.915661133484531 0.188020797908733 no 625 0.179922328144185 922 5497911 SGTC_1393 3470-5649 58.2 µM 0.915045723374748 0.188187548703461 no 626 0.180083813490799 788 4108395 SGTC_2300 7976697 71.57 µM 0.915030637671105 0.18819163745347 no 627 0.180087773164201 784 2236109 SGTC_586 0957-0265 8.15 µM 0.912331441673643 0.188924095566805 no 628 0.180797133851841 818 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1312 1218-2183 165 µM 0.911831050087997 0.189060075355879 no 629 0.180928831180984 929 6744073 SGTC_201 4262-0159 12.803 µM 0.910790315291325 0.189343084667035 no 630 0.181202933141783 846 1341029 SGTC_1126 isoteolin 1.0172 µM 0.909511368578759 0.189691228393305 no 631 0.181540129799738 875 133323 SGTC_3352 9151559 45.5865 µM 0.908201277557226 0.190048257893122 no 632 0.18188594462415 868 17159339 SGTC_424 splitomicin 100 mM 0.907020174481359 0.19037048901538 no 633 0.182198064375441 827 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.905153885797798 0.190880337499073 no 634 0.182691934049321 935 6708739 YPR165W RHO1 SGTC_2790 5423970 71.43 µM 0.904087212451826 0.191172116181096 no 635 0.182974579235285 936 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_781 4335-2806 94.4 µM 0.903469264791266 0.191341275106455 no 636 0.183138446653245 1001 845254 SGTC_2139 5578692 56.4705 µM 0.90338155489879 0.191365292519039 no 637 0.18316171298725 875 650991 YMR113W FOL3 SGTC_2421 5690543 90.72 µM 0.903254703714459 0.191400031176079 no 638 0.183195365383608 897 3397993 SGTC_175 3793-3120 23.7 µM 0.902945593453792 0.191484698322742 no 639 0.183277385502603 870 5322297 SGTC_1297 1068-0111 14.1 µM 0.901630944360802 0.19184504482567 no 640 0.183626473646935 869 767057 SGTC_1527 coumarin 137 µM 0.901406806142259 0.191906522711435 no 641 0.183686031980826 854 323 A hepatotoxic, DNA x-linker. SGTC_1958 st076513 41.9 µM 0.899898979259554 0.192320411277494 no 642 0.18408700669767 913 732122 YGL099W LSG1 SGTC_1646 st011709 75.6 µM 0.89856638364892 0.192686654074513 no 643 0.184441835579845 883 5757843 SGTC_3268 9137683 49.47 µM 0.897905916554207 0.192868330851423 no 644 0.184617855060874 889 1953228 SGTC_1691 st019933 84.6 µM 0.89788577293246 0.19287387346508 no 645 0.184623225129524 912 6176082 SGTC_1077 5-fluorocytosine 377 nM 0.897647123247246 0.192939546469191 no 646 0.184686853910122 883 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_178 4092-0806 87.505 µM 0.896307699814422 0.193308390141693 no 647 0.185044223938886 933 2169044 SGTC_3209 9113616 49.47 µM 0.892792943411215 0.194278310130848 no 648 0.185984032996828 958 16649353 SGTC_674 0498-0004 451 µM 0.891731719685633 0.194571743220695 no 649 0.186268373763751 872 4231473 SGTC_1092 toremifene 6.32 µM 0.891081119426434 0.19475177037785 no 650 0.186442826555944 1005 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1594 piperine 70.1 µM 0.890739130450113 0.194846442532418 no 651 0.186534568487534 904 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_557 1315-0110 16.2 µM 0.888674973602225 0.195418453215082 no 652 0.187088892417217 967 6833801 SGTC_918 glabranin 770.725 nM 0.887872454289096 0.195641119168913 no 653 0.187304681677935 921 124049 Also referred to as licorice root. SGTC_1118 chelidonine 707.474 nM 0.886631478200714 0.195985741871196 no 654 0.187638670305882 985 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1695 st026914 34.495 µM 0.886507426382463 0.19602021166042 no 655 0.187672077061289 919 3289191 SGTC_1014 4130-3005 69.3 µM 0.884967064294404 0.19644853227256 no 656 0.188087197628522 922 743608 SGTC_2867 9039098 71.43 µM 0.884534881487889 0.196568808955427 no 657 0.18820377066336 875 6463460 SGTC_3273 9137859 49.47 µM 0.883038270298697 0.196985661212078 no 658 0.188607797262207 938 2377234 SGTC_1999 st074831 12.5 µM 0.882789318192793 0.197055053903183 no 659 0.188675056448909 931 17112523 SGTC_2871 9038510 12.99 µM 0.882201254496272 0.19721902899941 no 660 0.188833991838975 979 4945164 SGTC_2720 fluspirilene 36.88 µM 0.881590290431832 0.197389477017607 no 661 0.188999203844265 854 3396 An atypical antipsychotic. SGTC_2793 7325131 81.82 µM 0.880855976580878 0.197594455256283 no 662 0.189197888889431 886 4176441 SGTC_1531 st059297 52.4 µM 0.880669917011757 0.197646412822736 no 663 0.189248251883906 940 7566702 SGTC_409 arachidonic acid 100 µM 0.87880249280054 0.198168352598248 no 664 0.189754187222612 929 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1989 st071868 50.2 µM 0.878196895631713 0.198337793810506 no 665 0.189918438204287 972 16414057 SGTC_966 1300-0360 30.2 µM 0.875620878114633 0.199059519170413 no 666 0.190618085743123 893 70588 SGTC_2517 totarol 10 µM 0.875033449690929 0.199224320859381 no 667 0.190777852830073 881 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1063 disulfiram 1.84 µM 0.874920717253458 0.199255957080389 no 668 0.190808522868143 937 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1382 3002-2117 298 µM 0.871005695317113 0.200356509840615 no 669 0.191875521689468 1008 1497314 SGTC_1521 st012942 49.4 µM 0.870079080010822 0.200617524349111 no 670 0.192128594674468 989 24207259 SGTC_768 0384-0033 77.3 µM 0.869743420541314 0.200712125253853 no 671 0.192220318836671 932 3965305 YMR134W ERG29 SGTC_2132 5317594 122.667 µM 0.868906500509359 0.200948115994896 no 672 0.192449136862547 894 794577 SGTC_3173 9105693 49.47 µM 0.868726850140067 0.200998794647612 no 673 0.192498275853265 980 17096658 SGTC_719 2810-4230 27.3 µM 0.868418258738123 0.201085864945846 no 674 0.192582701430433 946 721079 SGTC_638 3970-0837 4.09 µM 0.868389996719441 0.201093840318068 no 675 0.192590434589146 926 4118451 YLR208W SEC13 SGTC_2585 alliin 100 µM 0.867893901284632 0.201233866365636 no 676 0.192726208972137 954 87310 A garlic compound which reacts with lipids. SGTC_2424 5537928 59.2 µM 0.865035213539 0.202041887281327 no 677 0.193509730811585 984 5382802 SGTC_2224 6650123 117.647 µM 0.864828926399407 0.202100270284755 no 678 0.193566345972118 932 2908370 SGTC_2798 7813637 45.45 µM 0.860498150553831 0.20332828766601 no 679 0.194757251280999 929 956368 SGTC_2712 st079126 47.7 µM 0.860132557230502 0.203432157247349 no 680 0.194857988142809 919 3152970 SGTC_171 k064-0041 9.68 µM 0.857855856880904 0.204079708013284 no 681 0.195486030960348 868 53325 SGTC_130 0136-0219 337.655 µM 0.857557137000443 0.204164762479578 no 682 0.195568525947358 954 234244 SGTC_109 0132-0036 33.701 µM 0.854651033795565 0.204993318033583 no 683 0.196372183001176 850 67274 A color developer. SGTC_1428 4049-0204 61.7 µM 0.854180129186282 0.205127765015381 no 684 0.196502595698491 1013 X1428 SGTC_3046 9092212 49.47 µM 0.854140533141529 0.205139072386477 no 685 0.196513563850093 942 25236637 SGTC_2566 crystal violet carbinol 226 nM 0.851217983969717 0.205974681681239 no 686 0.19732413727496 842 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_727 3032-0951 202 µM 0.850683436819872 0.206127736415327 no 687 0.197472613203439 921 3652836 SGTC_3227 9130768 49.47 µM 0.850348190380398 0.206223760576637 no 688 0.197565765783306 995 17720899 SGTC_1750 st081859 2.357 µM 0.850036485183098 0.206313065637894 no 689 0.197652400950493 1069 5291695 SGTC_804 1595-0054 20.9 µM 0.849752457227743 0.206394460988475 no 690 0.19773136351139 920 761523 Stimulates phospholipase C. SGTC_471 1-acyl-paf 4 µM 0.846665130420525 0.207280438954447 no 691 0.198590899900063 942 16759367 SGTC_355 1311-2252 105 µM 0.844049581790704 0.208032786295099 no 692 0.199320849880076 931 5338538 SGTC_227 fluconazole 33.516 µM 0.843144882925274 0.208293392402243 no 693 0.199573709748286 1016 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2510 benzyl isothiocyanate 8.31 µM 0.841914768996743 0.208648045849729 no 694 0.199917831410331 944 2346 DNA damaging agent; causes G2/M arrest. SGTC_391 gliotoxin 8.33 µM 0.841746227617886 0.208696665629475 no 695 0.199965008267777 1010 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.837821502012146 0.209830733355294 no 696 0.201065480343221 984 279621 SGTC_213 1246-0773 967 nM 0.837268331211846 0.209990865399156 no 697 0.201220878027238 988 6251622 SGTC_1881 5652484 16 µM 0.837197731018282 0.210011307929733 no 698 0.201240716334499 941 2255129 SGTC_3158 9100007 49.47 µM 0.836782523648506 0.210131556320471 no 699 0.20135741128971 963 19297233 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.836215703125176 0.210295778741609 no 700 0.201516782923713 972 5355888 SGTC_612 0302-0167 22.4 µM 0.836202071971539 0.210299728963644 no 701 0.201520616494528 1050 235821 SGTC_3098 9119039 49.47 µM 0.835874465945001 0.210394680222669 no 702 0.20161276424016 1000 17161528 SGTC_701 4424-0219 185 µM 0.834829692940833 0.210697658690308 no 703 0.201906802479496 1053 2911779 SGTC_2135 5326629 150.42 µM 0.833004500207588 0.211227568335163 no 704 0.202421095627757 936 5020077 SGTC_192 3455-0609 60.9 µM 0.832294298928048 0.21143397248503 no 705 0.202621423897799 988 3769639 SGTC_1557 sumaresinolic acid 42.3 µM 0.832015326584486 0.211515081869986 no 706 0.20270014673545 947 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1706 st031321 9.9705 µM 0.830452304315024 0.211969857242105 no 707 0.203141551896222 1030 6103185 SGTC_688 0527-0193 473 µM 0.826455808901754 0.213135270879705 no 708 0.20427278810689 963 4007154 SGTC_2683 piperine 63.03 µM 0.826221585546575 0.213203688234519 no 709 0.204339202833237 973 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_399 oxolinic acid 75 µM 0.82392933182027 0.213873938261475 no 710 0.204989856444325 974 4628 A DNA gyrase inhibitor. SGTC_100 0086-0128 49.5915 µM 0.823924110753764 0.213875466289087 no 711 0.204991339842527 1037 93297 SGTC_821 1114-0266 29.2 µM 0.823823791626427 0.213904827501295 no 712 0.205019843536758 980 3123235 SGTC_152 4469-0003 551.229 µM 0.822765638513599 0.214214668646839 no 713 0.205320640254092 1018 697280 SGTC_1966 st070145 16.1 µM 0.822137667097036 0.214398670329207 no 714 0.205499274920652 1006 3748532 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.815405920185588 0.216376903072392 no 715 0.207419998348021 946 2374 Ca(2+)-ATPase inhibitor. SGTC_2054 5233173 129 µM 0.814973926785365 0.216504211033996 no 716 0.207543617374535 1008 6889 SGTC_158 k038-0087 26.446 µM 0.813768309653834 0.216859734199115 no 717 0.207888846436513 1035 X158 SGTC_1371 2421-0008 32.7 µM 0.811545182464882 0.217516194064991 no 718 0.208526328429754 971 2827552 SGTC_776 4476-4378 112 µM 0.811273855849012 0.217596391666377 no 719 0.208604210213316 967 2892008 SGTC_1692 fluoroquinolonic acid 71 µM 0.808827309541455 0.218320301960529 no 720 0.209307242660754 999 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1350 1495-0454 146 µM 0.808400685788236 0.218446677871307 no 721 0.209429978653775 1064 1069057 SGTC_2923 7992654 58.14 µM 0.808226102265304 0.218498405730026 no 722 0.209480217043171 1000 2985126 SGTC_1272 0839-0021 27 µM 0.808032557012287 0.21855576005821 no 723 0.209535920171563 1028 5027250 SGTC_2194 5927483 104.545 µM 0.807605185632809 0.21868243606477 no 724 0.2096589502882 1073 760979 SGTC_1240 0356-0016 42.1 µM 0.807434056026387 0.21873317198002 no 725 0.209708226364675 991 4305613 SGTC_1364 1653-0028 37.6 µM 0.807334885211271 0.218762576901286 no 726 0.209736785315287 992 5718652 SGTC_363 0455-0021 3.06 µM 0.80655893871123 0.218992729618377 no 727 0.209960319280746 1032 4597466 SGTC_476 mead acid 10 µM 0.806403382475185 0.219038885750557 no 728 0.210005148621297 1024 5312531 An omega 9 fatty acid. SGTC_1857 st056007 79.3 µM 0.805979816739957 0.219164593127905 no 729 0.210127243414628 1019 619834 SGTC_3008 9078912 71.4286 µM 0.805421924313857 0.219330229744156 no 730 0.210288122116239 1003 16648731 SGTC_2349 9023730 187.07 µM 0.803400273757763 0.21993105416743 no 731 0.210871708428437 1020 4126287 SGTC_1820 st053765 18.6 µM 0.80249744372832 0.220199675507588 no 732 0.211132633250251 1045 3690829 SGTC_1449 4112-4002 201 µM 0.802396631813747 0.220229682008863 no 733 0.211161780407635 973 2059539 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.802302350173284 0.220257746906434 no 734 0.211189041638871 964 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1603 st002045 67.8 µM 0.802082764184532 0.220323119207232 no 735 0.211252542211319 1056 5887985 SGTC_1689 st020265 53.493 µM 0.801779968340308 0.22041328191205 no 736 0.211340124019246 1033 5758320 YPR016C TIF6 SGTC_2303 7774051 200 µM 0.800594628715676 0.220766440677063 no 737 0.211683180643127 998 2953184 SGTC_83 0170-0301 39.027 µM 0.800539311155443 0.220782929839634 no 738 0.21169919840355 998 3089716 SGTC_2483 5729050 27.16 µM 0.800057279681329 0.220926644535371 no 739 0.211838805523761 1087 2865180 SGTC_1225 1216-0074 20.6 µM 0.799211528800443 0.22117892928154 no 740 0.212083884059945 1029 4241466 SGTC_993 3909-8757 62.7 µM 0.794328139487924 0.222638847859855 no 741 0.213502213218197 960 4288324 YLR208W SEC13 SGTC_1889 st059080 5.18 µM 0.792707003156304 0.223124708071645 no 742 0.213974274579478 1083 176925 Isolated from Daphnopsis sellowiana. SGTC_2727 riluzole 51.77 µM 0.792002406158712 0.223336066315179 no 743 0.214179636620414 1044 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_949 1165-0505 146 µM 0.791420326160182 0.223510758992577 no 744 0.214349376290463 1071 6244267 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.790375559052074 0.223824507268538 no 745 0.214654235770259 1101 1377 SGTC_2276 7947513 42.08 µM 0.789999178933717 0.223937597220666 no 746 0.214764123918173 1001 2105100 SGTC_203 k066-0004 30.888 µM 0.787829845021837 0.224590043836727 no 747 0.215398120641082 1160 6795412 SGTC_3341 9147222 25.867 µM 0.786495500094066 0.224991895102193 no 748 0.215788627159503 1011 1939759 SGTC_2403 6032726 181.2 µM 0.783465268712372 0.225905991274139 no 749 0.216676970645883 1040 2881040 SGTC_2818 7996756 12.99 µM 0.783265005417813 0.225966476360439 no 750 0.216735754308563 1050 2241621 SGTC_455 paf C-16 10 µM 0.781296732363398 0.226561436565748 no 751 0.21731399577324 1039 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_52 0329-0193 875 nM 0.779674248574313 0.227052537455542 no 752 0.217791320047763 1046 3739292 SGTC_1588 farnesol 29.9 µM 0.778224966561621 0.227491719887433 no 753 0.218218200386129 1041 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_553 k007-0256 45.7 µM 0.777937492593935 0.227578891242205 no 754 0.218302931982819 1097 6287000 SGTC_3280 9140961 49.47 µM 0.777763904705984 0.227631537780292 no 755 0.218354105371343 1035 4901226 SGTC_906 1165-0455 526 µM 0.777638112909019 0.22766969278306 no 756 0.218391192878262 1053 3252859 SGTC_2765 myclobutanil 7.74 µM 0.776581154133367 0.22799043031451 no 757 0.218702961944345 1062 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3335 9143315 29.6265 µM 0.776279903642449 0.228081892264833 no 758 0.218791868101246 1042 4899691 SGTC_1285 0929-0069 65.5 µM 0.775512901770191 0.228314853014679 no 759 0.219018322384713 1060 1206237 SGTC_1365 1672-3266 55.4 µM 0.774286789564307 0.228687536526713 no 760 0.219380607020873 1088 6415873 SGTC_1405 3909-7894 12 µM 0.774250636910962 0.228698530505452 no 761 0.21939129442422 1094 7104060 SGTC_387 norethindrone acetate 66.7 µM 0.773917528321336 0.228799842393284 no 762 0.219489781656009 1020 541197 SGTC_643 k048-0106 28.4 µM 0.773457968719748 0.22893965452892 no 763 0.219625697206446 1069 6763920 SGTC_850 0388-0143 75.9 µM 0.772922352675743 0.229102665851269 no 764 0.219784167557822 1033 67273 SGTC_837 0091-0265 12.5 µM 0.772600752409201 0.229200574111422 no 765 0.219879349536342 1061 759367 SGTC_245 methotrexate 289.6 µM 0.772515779134711 0.229226447366087 no 766 0.219904502484659 1078 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2921 7974240 10.71 µM 0.772471874954531 0.229239816258453 no 767 0.219917499212827 1066 2979074 YDR527W RBA50 SGTC_1900 st060200 72.8 µM 0.772239118341856 0.229310698317709 no 768 0.219986408315675 1082 688945 SGTC_2842 9000675 19.48 µM 0.772094901633649 0.22935462322261 no 769 0.220029110821683 1072 2989072 SGTC_1150 3909-7983 10.9 µM 0.771531820310866 0.229526169261016 no 770 0.220195884486474 1062 23965914 SGTC_3104 9120930 49.47 µM 0.771489556845544 0.229539047974353 no 771 0.220208405021573 1026 17014836 SGTC_1656 st012921 11 µM 0.770247403561115 0.229917743287065 no 772 0.220576574733699 1000 6732821 SGTC_3032 9089427 49.47 µM 0.769876338009755 0.230030937857389 no 773 0.220686625586521 1068 17173707 SGTC_1278 0874-0585 172 µM 0.769197216587312 0.230238186466517 no 774 0.220888121272196 1086 766306 SGTC_1997 st073024 93.8 µM 0.767297568351388 0.230818459538307 no 775 0.221452306934713 1094 686268 SGTC_2880 9042983 58.44 µM 0.764419984205748 0.231699009909472 no 776 0.222308501695316 1108 6464714 SGTC_3221 9128209 49.47 µM 0.76422755197942 0.231757961512143 no 777 0.222365825161714 1058 16460723 SGTC_605 1315-0399 119 µM 0.763822957071555 0.231881936392928 no 778 0.222486377078909 1121 24020461 SGTC_1192 1488-0095 21.4 µM 0.763371394004738 0.232020346736905 no 779 0.222620967491527 1047 915875 SGTC_1489 4065-0444 182 µM 0.763324551923393 0.232034707117406 no 780 0.222634931642151 1087 2877968 SGTC_995 3931-2021 34.6 µM 0.762988228125214 0.232137828460169 no 781 0.222735208206085 1049 730143 SGTC_2273 7815444 169.05 µM 0.761536958220844 0.232583099478206 no 782 0.223168206396061 1077 2824616 SGTC_2471 5466956 24.79 µM 0.760732605855686 0.232830091023486 no 783 0.223408397726411 1067 724419 SGTC_1442 4112-3290 3 µM 0.759666595795139 0.233157653926625 no 784 0.223726950378046 1119 704353 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.759511803245332 0.233205239746445 no 785 0.223773228041898 1048 1241132 A phosphatase inhibitor. SGTC_2323 6148992 148.28 µM 0.759502561585311 0.233208080957891 no 786 0.223775991153432 1019 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2332 7982454 138.89 µM 0.758555028819817 0.233499487819697 no 787 0.22405939151762 1077 2981748 SGTC_3333 9141820 12.094 µM 0.755035023098823 0.234583806945129 no 788 0.225113984090448 1043 1939433 SGTC_2400 5203494 178.7 µM 0.754875004338621 0.23463316596957 no 789 0.225161992394143 1068 6777674 SGTC_480 am 92016 50 µM 0.754588724740338 0.234721485453674 no 790 0.225247895528889 1047 2129 K+ channel blocker. SGTC_1503 4585-0012 61.3 µM 0.754426274875692 0.23477161067454 no 791 0.22529664966863 1088 2922052 SGTC_1302 1159-0335 255 µM 0.753840593963769 0.234952376378598 no 792 0.225472472696298 1097 649284 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.753811797226864 0.234961266243109 no 793 0.225481119559149 1218 688664 SGTC_1203 3992-3522 103 µM 0.752812144523435 0.23526998504292 no 794 0.225781403923882 1170 5322312 SGTC_693 4161-2696 114 µM 0.751093761756565 0.235801189380343 no 795 0.226298114894491 1091 805759 SGTC_463 ikarugamyin 104 µM 0.750859088014894 0.23587378545134 no 796 0.2263687321754 1129 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2245 6637752 200 µM 0.749023501451681 0.236442047050603 no 797 0.226921520302779 1074 681890 SGTC_1289 0976-0073 69.1 µM 0.744096489142091 0.237971072672435 no 798 0.228409051584181 1131 3391136 SGTC_407 eburnamonine 100 µM 0.743788742123107 0.238066756956148 no 799 0.228502146003153 1050 3195 SGTC_1107 amlodipine 47 µM 0.74301423107866 0.238307660159944 no 800 0.228736532275363 1043 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2680 butyl paraben 22.24 µM 0.742344941631843 0.23851594283263 no 801 0.228939184553941 1149 7184 An antifungal and steroid mimetic. SGTC_811 0416-0114 265 µM 0.741752579684493 0.238700368790642 no 802 0.229118628184771 1138 6612453 SGTC_101 0490-5701 117.494 µM 0.739196463922929 0.239497083887252 no 803 0.229893853866896 1064 4661669 SGTC_2607 solasodine 47.35 µM 0.738773924448351 0.239628924817067 no 804 0.230022144053164 1133 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_482 fipronil 114 µM 0.738521554223442 0.239707688363864 no 805 0.230098787061064 1147 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_472 calcifediol 10 µM 0.737702615443908 0.239963372537363 no 806 0.230347591215838 1077 5283731 A vitamin D metabolite. SGTC_469 w7 172 µM 0.736560675986267 0.24032015019698 no 807 0.230694778127384 1180 45115570 A P450 inhibitor. SGTC_3285 9112818 20.8695 µM 0.735361369496542 0.240695162042917 no 808 0.231059721015094 1192 17017947 YPR165W RHO1 SGTC_2885 9057732 51.95 µM 0.735062200925969 0.240788758848384 no 809 0.231150806683637 1159 6471414 SGTC_1187 1391-0724 117 µM 0.734899762473171 0.240839587054476 no 810 0.231200271524053 1149 6997986 SGTC_1979 st071809 45.3 µM 0.734533113807554 0.24095433561753 no 811 0.231311943011917 1142 4976333 SGTC_2656 pseudo-anisatin 100 µM 0.734348348301839 0.241012172203272 no 812 0.231368229097497 1139 6708809 A neurotoxin. SGTC_371 0195-0006 7.36 µM 0.733958020237543 0.241134380229871 no 813 0.231487161893118 1027 3928593 SGTC_917 harmaline 728.087 nM 0.733400733866666 0.241308919690855 no 814 0.231657025870769 1091 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3256 9138902 49.47 µM 0.733228435479782 0.241362896622231 no 815 0.231709557429486 1167 17228773 SGTC_1655 st012546 55.1 µM 0.732697401274179 0.241529298094715 no 816 0.231871504665409 1097 720985 YLR208W SEC13 SGTC_942 3253-1115 227 µM 0.731801619514046 0.241810135648206 no 817 0.23214483021951 1162 46497897 SGTC_1735 st034310 56.75 µM 0.731591211716412 0.241876126524643 no 818 0.232209056930602 1099 871153 SGTC_1961 st076550 68.7 µM 0.731418533747121 0.241930291372305 no 819 0.232261774046754 1091 1579337 SGTC_234 nsc-17383 10.7 µM 0.731291510504966 0.241970139650789 no 820 0.232300557413441 1171 408974 SGTC_3191 9110352 49.47 µM 0.731076211717505 0.242037688853713 no 821 0.23236630173604 1118 17122424 SGTC_1018 4259-0013 28.1 µM 0.729158336465531 0.242639866217294 no 822 0.232952406757435 1118 6801262 SGTC_1413 3910-0535 34.4 µM 0.728339287939471 0.242897279276609 no 823 0.233202958979602 1150 2876951 SGTC_1321 1326-2144 215 µM 0.727674053003676 0.243106460025142 no 824 0.233406568667629 1137 3513030 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.727378706964925 0.243199361747784 no 825 0.233496997379839 1170 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_137 0438-0332 85.389 µM 0.726557295144579 0.243457839465782 no 826 0.23374859845753 1204 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_312 4092-0653 6.84 µM 0.726515079505238 0.243471127678331 no 827 0.233761533302159 1164 1148278 SGTC_548 1436-0017 110 µM 0.726050814767518 0.243617290088413 no 828 0.23390380988759 1198 9677137 SGTC_2582 agaric acid 100 µM 0.725875655690508 0.243672446952821 no 829 0.23395750085213 1124 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2511 berberine 10.47 µM 0.725736284820099 0.243716339076376 no 830 0.234000226646677 1143 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3332 9141069 11.198 µM 0.724973682563955 0.243956581263829 no 831 0.234234087930414 1122 17332883 SGTC_263 alizarin 107.927 µM 0.724827567833446 0.244002626291475 no 832 0.234278910560453 1167 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3013 9080133 71.4286 µM 0.723470646601405 0.244430455724074 no 833 0.234695390825672 1206 17050193 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.723299319038588 0.244484503040494 no 834 0.234748005541315 1107 140250 A respiratory chain inhibitor. SGTC_214 4373-3496 70 µM 0.721516963509421 0.245047149979126 no 835 0.235295753768355 1242 3779166 SGTC_2817 7995342 71.43 µM 0.721271034847242 0.245124838412995 no 836 0.235371387193521 1129 18879975 SGTC_330 1488-0319 80.1 µM 0.720897688508027 0.245242803181982 no 837 0.235486232567312 1122 6846614 SGTC_2903 5923464 63.88 µM 0.719054472110935 0.245825644033351 no 838 0.2360536787922 1189 2876576 SGTC_3304 9125678 46.087 µM 0.718907149660105 0.245872260725114 no 839 0.236099065464065 1129 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1412 3909-8563 178 µM 0.718743292361819 0.245924115049498 no 840 0.236149551790387 1213 23767530 SGTC_216 k038-0035 28.382 µM 0.718314114668591 0.246059960548477 no 841 0.236281814576929 1105 4444231 YPR107C YTH1 SGTC_1716 st033144 30.6155 µM 0.7181588951597 0.246109101324355 no 842 0.236329659735298 1173 674617 SGTC_202 3594-0513 34.79 µM 0.716322300410613 0.246690946269347 no 843 0.23689617998048 1147 708429 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.715197031030638 0.247047802395091 no 844 0.237243651681707 1160 97141 SGTC_1922 5578187 25 µM 0.709639346272297 0.248814351187637 no 845 0.238963906803432 1166 1350412 SGTC_1010 4112-3296 15.2 µM 0.708740977888279 0.249100533904682 no 846 0.239242615271573 1209 704384 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.708582344250469 0.249151086152201 no 847 0.239291847978135 1189 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1839 st053978 48 µM 0.708170634102821 0.24928231248918 no 848 0.23941965000669 1224 3788398 SGTC_1829 berberine 14.4 µM 0.707912705414607 0.2493645420477 no 849 0.239499734569121 1172 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_486 niguldipine 82 µM 0.706870804790214 0.249696854319404 no 850 0.239823384264668 1175 1236 A calcium channel blocker. SGTC_1726 st035556 14.5795 µM 0.706547086390747 0.24980015157053 no 851 0.239923990747589 1190 5919439 SGTC_1546 5-methoxyflavanone 78.7 µM 0.706169664499977 0.249920614031932 no 852 0.240041316470345 1207 147795 SGTC_878 0828-0289 13.7 µM 0.703990287638328 0.250616812490241 no 853 0.240719411033973 1164 745350 YLR208W SEC13 SGTC_2732 terfenadine 20 µM 0.702867910003032 0.250975754598042 no 854 0.241069035559541 1173 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1349 flufenamic acid 69 µM 0.702845546327218 0.250982909379242 no 855 0.24107600472653 1154 3371 A non-steroidal anti-inflammatory. SGTC_306 1672-3436 11.6 µM 0.699806086074153 0.251956323232718 no 856 0.242024206718507 1207 6797378 SGTC_907 3448-6986 75.5 µM 0.699322268276635 0.252111453738195 no 857 0.242175326809793 1222 590582 SGTC_2710 st078562 53.7235 µM 0.697425908011506 0.252719984864699 no 858 0.242768146260221 1169 17250908 SGTC_901 1112-0062 60.1 µM 0.697274330765098 0.252768658494787 no 859 0.242815564560883 1212 1908457 SGTC_3344 9148862 3.898 µM 0.697162165517919 0.252804679543466 no 860 0.242850656730892 1220 4905352 SGTC_2370 9071495 200 µM 0.694951467259863 0.253515180287943 no 861 0.243542858519041 1146 21791103 SGTC_1249 0481-0015 10.2 µM 0.692996050006164 0.254144509090134 no 862 0.2441560151839 1174 4227577 SGTC_836 0330-0104 1.35 µM 0.690366113153124 0.254992214648419 no 863 0.244981990650649 1219 46494820 SGTC_831 k061-1017 217 µM 0.689521997703677 0.255264611024896 no 864 0.245247417511342 1251 1240153 SGTC_880 0833-0487 87.2 µM 0.689005156216019 0.255431471027992 no 865 0.245410011389859 1190 76075 SGTC_2278 7948257 134.34 µM 0.688110158059848 0.255720551997881 no 866 0.245691707054217 1186 1247028 SGTC_2096 5468907 200 µM 0.688042958622691 0.255742264050424 no 867 0.245712864706782 1219 759785 SGTC_1221 2958-7315 257 µM 0.68558036440008 0.256538588506013 no 868 0.246488883578736 1224 4562705 SGTC_2487 5918373 44.05 µM 0.685548711163821 0.256548832554391 no 869 0.246498866766892 1246 2876279 SGTC_104 0074-0074 590.992 µM 0.685509515595222 0.25656151784963 no 870 0.246511229049087 1083 3943124 SGTC_2030 5175110 200 µM 0.683853309643394 0.257097832506948 no 871 0.247033899829002 1244 2831986 SGTC_3255 9139072 49.47 µM 0.683316466338282 0.257271798807075 no 872 0.247203445708546 1227 17646060 SGTC_1255 0566-0045 221 µM 0.681901748174503 0.257730537007799 no 873 0.247650539965612 1235 2788469 SGTC_1563 conessine 56.1 µM 0.681427690073317 0.257884350579181 no 874 0.24780045339014 1292 441082 An anti-amoebic, histamine inhibitor. SGTC_2359 9039622 200 µM 0.681314015738755 0.257921240595519 no 875 0.24783640831234 1191 6463596 SGTC_35 0133-0054 64.071 µM 0.681286394900571 0.257930204625717 no 876 0.247845145138433 1169 99677 SGTC_3063 1327-0034 4 µM 0.678892677331316 0.258707672077515 no 877 0.24860293290466 1157 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1754 st042065 16.137 µM 0.678726953266479 0.258761543286086 no 878 0.248655442411127 1186 1126236 YIL048W NEO1 SGTC_1415 3966-0071 78.1 µM 0.677409327517384 0.259190064707653 no 879 0.249073140939071 1216 2893185 SGTC_2006 4011487 200 µM 0.67710325725008 0.259289658092815 no 880 0.24917022120588 1248 45595294 SGTC_1570 verbenone 133 µM 0.677074345509568 0.25929906681774 no 881 0.249179392556874 1242 29025 A natural terpanoid with antifungal properties. SGTC_23 0213-0011 39.996 µM 0.676147084140604 0.2596009182913 no 882 0.249473632596317 1249 627608 SGTC_1112 tnp00069 1.16933 µM 0.675115776746575 0.259936852842528 no 883 0.249801105435788 1264 145826 SGTC_2189 6047310 154.431 µM 0.674789926974869 0.260043040629152 no 884 0.249904620509356 1173 711535 SGTC_1649 st011737 51.3 µM 0.673890726749638 0.260336187603243 no 885 0.250190394066743 1208 1761035 SGTC_2287 7945887 168.79 µM 0.673515886283861 0.260458439062613 no 886 0.250309572749398 1250 1245853 SGTC_3302 9125395 16.351 µM 0.672879742872485 0.260665980196562 no 887 0.250511900282709 1199 17599668 SGTC_128 0906-2981 13.371 µM 0.670606980777208 0.261408161135842 no 888 0.251235467125183 1224 6740226 SGTC_3278 9139605 49.47 µM 0.669878748988898 0.261646197947009 no 889 0.251467543865388 1261 7958859 SGTC_474 dl-dihydrosphingosine 5 µM 0.669588925902637 0.26174096322952 no 890 0.251559937718142 1276 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1189 1431-2119 7.28 µM 0.667475518472134 0.262432529375048 no 891 0.252234221131899 1260 3107275 SGTC_2173 5763948 167 µM 0.667101427406354 0.262555039840486 no 892 0.252353674225204 1253 2867177 SGTC_1043 0916-0009 19.3 µM 0.666933692717141 0.26260998050004 no 893 0.252407244200764 1284 3101130 SGTC_406 estrone 100 µM 0.666797600195543 0.26265456124834 no 894 0.252450712917829 1262 5870 A steroid. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.666763792293458 0.262665636532044 no 895 0.252461511963679 1267 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_246 cycloheximide 667 µM 0.66661585352802 0.262714103272277 no 896 0.252508769977649 1138 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2722 naftopidil 47.16 µM 0.666309021535319 0.26281464016499 no 897 0.252606800189666 1219 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1681 tripelennamine 100 µM 0.664954714303319 0.263258628863387 no 898 0.253039729243713 1242 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3222 9128301 49.47 µM 0.664781960481949 0.263315291071493 no 899 0.253094981219261 1263 4911358 SGTC_1748 st037455 53.6035 µM 0.664159466567622 0.26351951694791 no 900 0.25329412650657 1238 580690 SGTC_144 4161-2749 112.381 µM 0.663785246852528 0.263642328687116 no 901 0.253413884731335 1178 797501 YMR168C CEP3 SGTC_2983 9022671 12.99 µM 0.663717216669446 0.263664658025712 no 902 0.253435659025198 1256 6405161 SGTC_1788 fluconazole 20 µM 0.663536974189605 0.263723823126462 no 903 0.253493353652782 1231 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1606 st000094 49.2 µM 0.662938801336129 0.26392022356148 no 904 0.2536848749424 1288 1242210 SGTC_1597 7-benzyloxygramine 47.5 µM 0.661797219864674 0.264295250279719 no 905 0.254050594052966 1226 260807 SGTC_2993 9054257 71.4286 µM 0.661128594963059 0.264515029570054 no 906 0.254264924310534 1253 6470217 YGL055W OLE1 SGTC_2654 protoveratrine a 100 µM 0.65961521937219 0.265012824515568 no 907 0.254750392522405 1235 5702278 A heart drug and vasodilator. SGTC_3083 9117465 49.47 µM 0.65934679959513 0.265101165558487 no 908 0.25483654820751 1237 16420915 SGTC_2121 5257820 149.641 µM 0.659107567018753 0.265179913253009 no 909 0.254913348421579 1286 791256 SGTC_2416 tofa 880 nM 0.658459767381476 0.265393207740998 no 910 0.255121370650462 1191 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2372 9071633 200 µM 0.658330604525393 0.265435746307023 no 911 0.255162858201795 1274 21321366 SGTC_438 sphingosine 6.67 µM 0.657199958987926 0.265808261367585 no 912 0.255526175980349 1138 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3234 9132280 49.47 µM 0.656754529420747 0.265955090274123 no 913 0.255669382967809 1261 17612295 SGTC_3074 9116018 49.47 µM 0.654991906133572 0.266536514274297 no 914 0.256236482617069 1302 17027303 SGTC_843 0310-0051 143 µM 0.654904669583808 0.266565307060579 no 915 0.256264566791453 1260 2065037 SGTC_2404 5161160 200 µM 0.654308813543601 0.266762013879405 no 916 0.256456434393195 1229 2831543 SGTC_3267 9137951 49.47 µM 0.65283579455143 0.267248608525654 no 917 0.256931072363951 1263 16643986 SGTC_2387 9077560 195.08 µM 0.65274773655823 0.267277711639306 no 918 0.256959460988846 1240 5303272 SGTC_1892 st058411 7.36 µM 0.652682526645636 0.267299264506697 no 919 0.256980484774275 1237 3934738 SGTC_1180 1193-0155 285 µM 0.652200864437421 0.267458488344252 no 920 0.257135801190909 1256 2921347 SGTC_1518 st038567 90.8 µM 0.652172610863852 0.267467829657718 no 921 0.257144913331397 1262 77966 SGTC_1003 4049-0218 100 µM 0.650846824523829 0.267906351549845 no 922 0.257572685182412 1301 295161 SGTC_2244 6635614 200 µM 0.650786296684289 0.267926380597013 no 923 0.257592223621994 1207 836499 SGTC_2803 7707263 71.43 µM 0.650364723622047 0.268065902718993 no 924 0.257728329121461 1264 2199229 SGTC_699 0375-0592 111 µM 0.650275193844094 0.268095537841305 no 925 0.257757238750569 1291 762578 SGTC_2618 avocadyne 43.43 µM 0.649873690685284 0.268228459098268 no 926 0.257886906897856 1228 3015189 SGTC_984 1492-0255 2.91 µM 0.648537824761406 0.268670948169206 no 927 0.258318577308412 1243 1585198 SGTC_1467 k284-1082 293 µM 0.647869156781896 0.268892573831863 no 928 0.258534790564319 1274 3334705 SGTC_1373 2887-0003 58.5 µM 0.645964590048465 0.269524332797875 no 929 0.259151143953963 1269 776948 SGTC_484 loperamide 105 µM 0.645946412502047 0.269530366007098 no 930 0.259157030205191 1239 3955 An opioid-receptor agonist. SGTC_1995 st072814 61.1 µM 0.645830453197427 0.269568855013548 no 931 0.259194581762111 1226 5769371 SGTC_32 0928-0142 34.1 µM 0.644318475954962 0.270070959742489 no 932 0.259684468581753 1241 2244242 SGTC_2600 tangeritin 87.95 µM 0.643858332957747 0.270223859072023 no 933 0.259833651595132 1238 68077 A bioactive flavone. SGTC_673 1082-0474 110 µM 0.643624310731219 0.27030163811319 no 934 0.259909540926796 1289 3098046 SGTC_1728 st035614 33.7865 µM 0.643162695072838 0.270455092343125 no 935 0.260059268355391 1305 15945546 SGTC_2246 7293507 91.5585 µM 0.64262453460419 0.270634047197851 no 936 0.260233879617605 1292 887656 SGTC_2258 7960471 200 µM 0.641973315130247 0.27085067668833 no 937 0.26044525470505 1232 2974708 SGTC_252 miconazole 1.30953 nM 0.641105783979744 0.271139397076043 no 938 0.26072697828325 1239 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.639038309276736 0.271828085107078 no 939 0.261399005230974 1314 676296 Flavone; oxidizing agent. SGTC_1006 4099-6547 255 µM 0.638641968220369 0.271960208007349 no 940 0.261527936336438 1300 3146833 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.638262199156682 0.272086836483417 no 941 0.261651507136603 1279 115019 SGTC_1119 parthenolide 318.541 nM 0.635687283474576 0.272946177107672 no 942 0.262490133238518 1387 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2190 6049624 200 µM 0.634718057077151 0.273269990572743 no 943 0.262806157330825 1231 2265554 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.634381161593068 0.273382590141251 no 944 0.262916050379343 1301 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1505 k297-0037 20.6 µM 0.632109973268892 0.27414228157994 no 945 0.263657509350664 1281 4089396 SGTC_758 0868-0029 16 µM 0.630580216482194 0.274654558131908 no 946 0.264157518867819 1304 762687 SGTC_2812 7970281 58.44 µM 0.630152103260933 0.27479800684023 no 947 0.264297536507262 1339 2233435 SGTC_12 0849-0099 9.267 µM 0.62993147801193 0.274871946578972 no 948 0.264369708401448 1256 6071388 SGTC_3147 9097027 49.47 µM 0.629246025784818 0.275101729687641 no 949 0.26459400051098 1343 25236841 SGTC_33 0986-0033 35.816 µM 0.62830799849833 0.275416336385401 no 950 0.26490109645432 1256 2848082 SGTC_2396 5342950 42.78 µM 0.627860285409497 0.275566558083461 no 951 0.265047734784695 1314 1886677 SGTC_2158 5657123 3.6195 µM 0.627068144365421 0.275832444771734 no 952 0.265307283715378 1279 2858827 SGTC_1870 st057514 26.5 µM 0.626932045145725 0.275878139942176 no 953 0.265351890282061 1296 5393161 SGTC_1983 st071813 46.9 µM 0.624541744894074 0.276681286428888 no 954 0.266135932020228 1297 11838595 SGTC_1261 0712-0010 12.7 µM 0.623591361555579 0.277000935491141 no 955 0.26644799259841 1325 2840123 SGTC_2002 4023503 131 µM 0.621977227508979 0.277544242360822 no 956 0.266978421092533 1356 4736863 YCR052W RSC6 SGTC_788 1182-0090 188 µM 0.62146361262589 0.277717230889033 no 957 0.267147314374806 1422 5715185 SGTC_1159 4092-0538 61.2 µM 0.620102969195489 0.278175758009896 no 958 0.267594998743381 1344 717301 SGTC_1957 st077035 62.4 µM 0.619773889911778 0.278286710797467 no 959 0.267703330500237 1380 705593 SGTC_1427 4048-4900 550 nM 0.618450823045458 0.278733015307678 no 960 0.268139102456802 1327 24132586 SGTC_2953 9074162 66.49 µM 0.617472396845399 0.279063287606231 no 961 0.268461591296143 1320 16451992 SGTC_2449 5812982 45.77 µM 0.616282414387416 0.279465227994133 no 962 0.268854071621023 1297 776185 SGTC_554 4483-2211 187 µM 0.616168049963243 0.279503871670556 no 963 0.268891806496702 1309 747107 SGTC_640 3381-0960 37.1 µM 0.616031772845075 0.279549923022151 no 964 0.268936775001982 1372 1745025 SGTC_2188 6126565 140.678 µM 0.616019400116236 0.279554104250453 no 965 0.268940857922186 1298 874518 SGTC_752 1896-0090 130 µM 0.614492665037994 0.280070280557506 no 966 0.269444909304615 1322 772567 SGTC_2187 6125751 200 µM 0.61400503597572 0.280235241127947 no 967 0.269605999694286 1305 874498 SGTC_3122 9126309 49.47 µM 0.609536527374199 0.281749085716655 no 968 0.271084434416979 1347 17591206 SGTC_2098 5376439 882.5 nM 0.609486806684248 0.281765952279246 no 969 0.271100907543771 1383 2844116 SGTC_2203 7227154 166.4 µM 0.609370061207129 0.281805557321079 no 970 0.271139588837396 1311 896304 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.608377347558412 0.282142436459594 no 971 0.271468615931277 1310 6857784 SGTC_2138 5575593 77.673 µM 0.608053631142777 0.282252332102508 no 972 0.27157595216679 1304 762213 SGTC_2270 7924575 90.91 µM 0.607864918713574 0.282316405930733 no 973 0.271638534219783 1353 1262135 SGTC_2507 purpurin 79.67 µM 0.607680633413182 0.282378983362084 no 974 0.271699655047949 1299 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2436 5633522 8.09 µM 0.607500598188423 0.282440124045354 no 975 0.271759372888508 1329 5724242 SGTC_1657 st012939 43.4 µM 0.60686010668558 0.282657689124801 no 976 0.27197187742166 1362 24207257 SGTC_317 4495-0002 170 µM 0.606495167437867 0.282781689365084 no 977 0.2720929952041 1286 15991618 SGTC_642 0335-0876 158 µM 0.605981437111107 0.282956290594402 no 978 0.272263539914245 1353 6812350 SGTC_2353 9059630 146.67 µM 0.603865664177304 0.283675922150698 no 979 0.272966479236511 1356 4779114 SGTC_3065 9113888 49.47 µM 0.600677936772302 0.284761806846529 no 980 0.274027258494242 1405 16648368 SGTC_5 0352-0601 109.883 µM 0.598830350527857 0.285392085360434 no 981 0.274643010437397 1261 762456 SGTC_1815 st051655 58.2 µM 0.598513433750357 0.285500263855604 no 982 0.274748698997246 1310 5984156 SGTC_2848 9016370 25.97 µM 0.598109883847174 0.285638042530381 no 983 0.274883307851601 1361 7894410 SGTC_2347 9049783 174.81 µM 0.597177730354929 0.285956416186285 no 984 0.275194362892161 1370 6467988 YPL169C MEX67 SGTC_1306 1185-0270 9.02 µM 0.596573750296102 0.28616279340528 no 985 0.275396000550188 1343 1548076 SGTC_760 0568-0725 82.9 µM 0.595945041760716 0.286377695355175 no 986 0.275605970955573 1361 3916171 SGTC_111 0083-0039 52.457 µM 0.595395691721345 0.286565534075105 no 987 0.275789502342463 1264 759313 SGTC_1034 k072-0165 12.7 µM 0.594557284046723 0.286852322598232 no 988 0.276069720211616 1365 5835461 SGTC_2809 7964133 12.99 µM 0.594426076769791 0.286897216102024 no 989 0.276113585777088 1374 1253665 SGTC_2811 7967822 32.47 µM 0.593660373039622 0.287159273464642 no 990 0.276369646110512 1405 2232244 SGTC_985 1493-0307 8.71 µM 0.593465133314057 0.287226111178466 no 991 0.276434955202465 1321 3278274 SGTC_1385 3091-4834 14.1 µM 0.592801682293318 0.287453289783375 no 992 0.276656940880557 1362 4072814 SGTC_1056 3448-1962 115 µM 0.591962298651287 0.287740832867048 no 993 0.276937917398398 1373 715507 SGTC_2965 9082772 38.63 µM 0.591482623734106 0.287905213488343 no 994 0.277098547199224 1394 16459634 SGTC_2057 5236571 38.335 µM 0.590975304741876 0.288079115740606 no 995 0.277268483828312 1396 54684039 YBR257W POP4 SGTC_1793 st048256 72.231 µM 0.590742597376673 0.288158901333859 no 996 0.277346450857622 1293 672022 SGTC_2568 diosmetin 100 µM 0.590489333554182 0.28824574671959 no 997 0.277431317369859 1353 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_767 0929-0023 86 µM 0.590279200153917 0.28831781184472 no 998 0.277501740885947 1383 1204563 SGTC_36 0335-0881 14.2 µM 0.58962021055037 0.288543867020703 no 999 0.277722649451604 1307 23828853 SGTC_3343 9148379 18.9835 µM 0.589051650278196 0.288738969034542 no 1000 0.27791331300339 1423 1955036 SGTC_1032 k061-1018 98.7 µM 0.585604866272266 0.289923063993335 no 1001 0.279070538729437 1502 4005393 SGTC_2612 dictamnine 15.46 µM 0.585440001885613 0.289979757891959 no 1002 0.279125949081826 1353 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1185 1319-0113 81.3 µM 0.585301621422366 0.290027348457607 no 1003 0.279172462407464 1394 4672763 SGTC_78 0336-0123 156.75 µM 0.584574816652769 0.290277364720405 no 1004 0.279416822515826 1321 6765896 SGTC_456 gingerol 170 µM 0.584561574803992 0.290281920769178 no 1005 0.279421275540893 1403 442793 A herb. SGTC_1602 st001878 87.6 µM 0.583459851575718 0.290661101774376 no 1006 0.279791888388784 1390 595405 YLR310C CDC25 SGTC_2621 lithochol-11-enic acid 100 µM 0.580728201936607 0.291602253901221 no 1007 0.280711825676629 1397 6708711 SGTC_2759 disulfiram 3.38 µM 0.577142311724911 0.292839875058557 no 1008 0.281921661725581 1324 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2217 6934799 96.0675 µM 0.575820402336208 0.293296728422794 no 1009 0.282368290835143 1363 675606 SGTC_970 1315-0089 19.5 µM 0.574326423035475 0.293813446609249 no 1010 0.282873465984841 1305 6811083 YLR033W RSC58 SGTC_1460 k062-0059 9.15 µM 0.573684936547338 0.294035444803751 no 1011 0.283090511768523 1334 1373085 SGTC_132 0417-1715 25.805 µM 0.572476117078279 0.294453989600239 no 1012 0.283499730700049 1447 6769098 SGTC_1622 st003707 19.4 µM 0.570938489565046 0.294986778771335 no 1013 0.284020669574742 1410 10140899 SGTC_348 k064-0012 10.7 µM 0.570522913915183 0.295130852274057 no 1014 0.28416154265742 1328 5066323 SGTC_1962 st076595 64.5 µM 0.569604915023731 0.295449222753961 no 1015 0.284472847051577 1387 279619 SGTC_2036 5160441 105 µM 0.569554482783046 0.295466717696712 no 1016 0.284489953946887 1425 134534 YIL048W NEO1 SGTC_2659 sanguinarine 24.21 µM 0.568495080424779 0.295834334420781 no 1017 0.284849422625779 1339 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2425 5628681 7.85 µM 0.56750872120089 0.296176793636158 no 1018 0.28518430152525 1407 5714958 SGTC_2490 carminic acid 95.39 µM 0.567412401027066 0.296210245285839 no 1019 0.285217013248033 1355 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2674 ligustilide 100 µM 0.567286657126138 0.296253918297964 no 1020 0.285259720384153 1363 5319022 A signalling regulator. SGTC_1390 3413-2614 145 µM 0.567077225615657 0.296326664006169 no 1021 0.285330857594715 1379 3421432 SGTC_2204 7233102 200 µM 0.566703880856086 0.296456365036072 no 1022 0.285457691867341 1361 2172480 SGTC_1432 4049-0298 68.4 µM 0.566627448599969 0.296482921027095 no 1023 0.285483661069054 1429 741646 SGTC_3240 9133527 49.47 µM 0.563908567488812 0.297428290417195 no 1024 0.286408179526309 1360 17617455 SGTC_1147 3809-1045 12.3 µM 0.563708996229824 0.297497736606839 no 1025 0.286476096953064 1338 325925 SGTC_1197 1601-0112 267 µM 0.563681303423862 0.297507373648759 no 1026 0.286485521880392 1360 7350313 SGTC_2884 9058502 51.95 µM 0.563475051660811 0.297579153339601 no 1027 0.286555721918774 1377 6471554 SGTC_2297 7971671 152.32 µM 0.562972010331175 0.297754254810519 no 1028 0.286726971737681 1462 909016 SGTC_1781 st038725 66.3 µM 0.560976865302319 0.298449198598947 no 1029 0.287406654213497 1395 4270275 YIL048W NEO1 SGTC_1875 nocodazole 6 µM 0.560391879478884 0.298653099193372 no 1030 0.287606084670238 1395 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1545 lovastatin 49.4 µM 0.560031716664185 0.298778667768684 no 1031 0.287728902110339 1435 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2165 5727197 32.143 µM 0.558540001387502 0.299299000536744 no 1032 0.288237848657817 1503 1361712 SGTC_1170 0310-0127 64.8 µM 0.558266053819587 0.299394602236531 no 1033 0.288331360793767 1434 774975 SGTC_281 1672-3440 14.9 µM 0.558225399775169 0.29940879078732 no 1034 0.288345239290514 1409 6833000 SGTC_750 4073-0104 132 µM 0.557734169181297 0.299580257854864 no 1035 0.288512960712192 1283 22330957 SGTC_333 3486-0131 40.1 µM 0.55729268037358 0.299734400202614 no 1036 0.288663737952966 1477 6744690 SGTC_663 1486-0733 13.9 µM 0.554841555484948 0.30059084372735 no 1037 0.289501520277179 1398 722445 YPR165W RHO1 SGTC_732 3970-1727 52.7 µM 0.553918859458695 0.30091352742638 no 1038 0.289817188767903 1496 1275699 SGTC_1210 3013-0140 750 nM 0.553679391596533 0.300997299248235 no 1039 0.289899140787575 1506 905973 SGTC_169 k015-0017 16.025 µM 0.553618734515938 0.301018520274337 no 1040 0.289919900915034 1481 1840002 SGTC_1690 st023502 41.2 µM 0.553378173623274 0.301102687723877 no 1041 0.29000224070333 1462 24207482 SGTC_1381 2324-0066 62.1 µM 0.553139664888491 0.301186147632825 no 1042 0.290083888895892 1420 10885928 SGTC_3088 9117578 49.47 µM 0.553068193512658 0.301211159205321 no 1043 0.290108357639206 1438 678341 SGTC_2480 5767542 37.17 µM 0.552824268341198 0.301296528425366 no 1044 0.290191874471996 1445 2867358 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.552489814045382 0.301413598843544 no 1045 0.29030640561724 1381 688662 SGTC_2679 rapamycin 1 nM 0.551082161799679 0.301906549449967 no 1046 0.290788676542993 1404 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2257 7960413 200 µM 0.549202554596034 0.302565339722825 no 1047 0.291433225742382 1412 2974689 YIL048W NEO1 SGTC_2802 7925815 54.55 µM 0.549052691711516 0.302617893426417 no 1048 0.291484644943521 1393 1262923 SGTC_666 0272-0154 136 µM 0.548706073532586 0.302739460666135 no 1049 0.291603588730143 1415 6870312 SGTC_2934 9036370 36.88 µM 0.546586402003638 0.303483355282298 no 1050 0.292331456612428 1492 6462800 SGTC_1810 st050138 53 µM 0.545351223291852 0.303917215021655 no 1051 0.292755990314279 1421 3444541 SGTC_1917 st066507 28.5 µM 0.545059869311166 0.304019594169612 no 1052 0.292856171046489 1424 3156428 SGTC_488 nitrendipine 139 µM 0.544137693371056 0.304343739726639 no 1053 0.293173361868616 1451 4507 Dihydropyridine L-type calcium channel blocker. SGTC_743 1275-0778 158 µM 0.543497070408782 0.304569009729916 no 1054 0.293393803701538 1488 2849257 YMR203W TOM40 SGTC_304 1310-0298 97 µM 0.543045121943072 0.30472797844709 no 1055 0.293549367803547 1366 1550234 SGTC_974 1326-0144 138 µM 0.54232601425213 0.304980993977486 no 1056 0.293796968849203 1415 5411856 SGTC_1320 1313-0481 95.3 µM 0.539530222827005 0.305965568733548 no 1057 0.294760524383874 1445 6813365 YLR208W SEC13 SGTC_1927 st060202 13.8 µM 0.53630493733777 0.307103139237088 no 1058 0.295873909431738 1422 688887 SGTC_2328 6201408 200 µM 0.536060774299105 0.307189332303653 no 1059 0.295958274347993 1407 2890418 SGTC_521 r062-0005 13.8 µM 0.534631974287823 0.307693932727206 no 1060 0.296452184565086 1424 2832033 SGTC_1845 st056753 3.01 µM 0.533196287260856 0.308201332075072 no 1061 0.296948855663858 1366 5375839 SGTC_1288 0973-0013 65.5 µM 0.532807545577203 0.308338783980453 no 1062 0.297083405009192 1472 4315430 SGTC_1789 tunicamycin 25 nM 0.528903423474075 0.309720697345322 no 1063 0.298436223493746 1414 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1717 st033143 58.0435 µM 0.528199956824227 0.309969985235231 no 1064 0.298680279681568 1541 674616 SGTC_1764 st044502 93.5 µM 0.527945927918878 0.310060027089879 no 1065 0.298768433128381 1415 8407 SGTC_2643 anethole 100 µM 0.52750980731663 0.310214638849391 no 1066 0.298919803848136 1425 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_444 curcumin 90.4 µM 0.526163885536024 0.310692001206846 no 1067 0.299387171998166 1441 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1676 st018489 23.4 µM 0.524937798079266 0.311127139147549 no 1068 0.299813216168357 1471 3696235 SGTC_1466 k213-0079 57.5 µM 0.524161961862659 0.311402619596427 no 1069 0.300082947554367 1431 3657981 SGTC_254 nsc-64875 3.808 µM 0.523933559669679 0.311483739757793 no 1070 0.300162375996443 1564 56993 SGTC_813 k007-0158 173 µM 0.521309211590943 0.312416468784435 no 1071 0.301075692510313 1533 6523916 SGTC_1179 1021-1431 9.29 µM 0.5207177012568 0.312626865970203 no 1072 0.301281720719998 1466 2840958 SGTC_3187 9109394 49.47 µM 0.519001427785974 0.313237681132591 no 1073 0.301879872794288 1363 17098090 SGTC_362 0310-0100 9.03 µM 0.518965151597666 0.313250597228311 no 1074 0.301892521453214 1464 790235 SGTC_2596 sinensetin 100 µM 0.517598968960175 0.31373719166833 no 1075 0.302369050650894 1446 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_869 0564-0080 44.1 µM 0.515684081033137 0.314419764490815 no 1076 0.303037537349038 1430 6843321 SGTC_2470 5664817 21.68 µM 0.515154081440208 0.31460879818428 no 1077 0.3032226767911 1487 2859561 SGTC_875 0709-0210 25.7 µM 0.515062078024565 0.31464161777593 no 1078 0.303254820572344 1484 6251364 SGTC_2399 5884133 200 µM 0.514547788370965 0.314825102893494 no 1079 0.303434529061648 1444 722445 SGTC_1175 0741-0056 27.6 µM 0.514339475188853 0.314899436609796 no 1080 0.303507333576527 1557 765927 SGTC_63 0099-0242 26.702 µM 0.51089823154408 0.316128480755451 no 1081 0.304711159782555 1456 3898502 YLR359W ADE13 SGTC_2223 6903751 107.57 µM 0.510452303937766 0.316287893506175 no 1082 0.304867310779351 1468 5598863 SGTC_1614 st002383 48.6 µM 0.510124295747268 0.316405173549335 no 1083 0.304982192486803 1467 1947235 SGTC_3340 9146634 11.102 µM 0.509294248343328 0.316702041280288 no 1084 0.305272994447157 1467 4907387 SGTC_1122 capsaicin 818.572 nM 0.508441103349709 0.31700729297303 no 1085 0.305572016642456 1563 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3247 9135149 49.47 µM 0.507694438627053 0.317274548714073 no 1086 0.305833824606198 1459 8934436 YOR116C RPO31 SGTC_2164 5685496 200 µM 0.506927848914254 0.317549035424097 no 1087 0.306102722272328 1485 759046 SGTC_1973 st070275 50.2 µM 0.506295993568536 0.317775354310573 no 1088 0.306324437570827 1444 17118334 SGTC_2761 levamisole 97.89 µM 0.503822453573771 0.318661984996089 no 1089 0.307193073833003 1567 26879 An alkaline phosphatase inhibitor. SGTC_18 0111-0177 500 nM 0.503085889447431 0.318926204538724 no 1090 0.30745194349504 1519 721752 SGTC_2085 5307070 144.047 µM 0.502668970714288 0.319075802012861 no 1091 0.307598514490951 1420 2840351 SGTC_2734 clemastine 41.6 µM 0.502616234458789 0.31909472677107 no 1092 0.307617056517349 1482 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3338 9144300 39.5675 µM 0.502099378042622 0.319280229104463 no 1093 0.307798808838354 1507 4901274 SGTC_2114 5491910 81.25 µM 0.501604059567522 0.319458043826959 no 1094 0.307973031618343 1563 2849228 SGTC_2202 7226349 200 µM 0.500794702981956 0.319748684653935 no 1095 0.308257806970007 1449 844334 SGTC_218 alverine citrate 93.75 µM 0.498808331703984 0.320462461750025 no 1096 0.30895720872915 1535 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1568 digitonin 820 nM 0.497403866762894 0.320967539514952 no 1097 0.309452139673434 1627 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_532 1548-0774 215 µM 0.49656022948769 0.321271090226557 no 1098 0.309749602272569 1593 5932993 SGTC_729 4092-0585 94.1 µM 0.496043032808027 0.321457242803685 no 1099 0.309932025065467 1449 2169061 SGTC_1809 st050081 57.6 µM 0.495828291789352 0.321534546877796 no 1100 0.31000778110057 1557 5036894 SGTC_2772 vinpocetine 57.06 µM 0.494915085980314 0.321863375808963 no 1101 0.310330030623481 1537 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_38 0929-0051 58.268 µM 0.494595057688542 0.321978645256857 no 1102 0.3104429957975 1585 1379719 SGTC_2243 6634756 200 µM 0.493781975301773 0.3222715825108 no 1103 0.310730082061554 1585 885676 SGTC_649 1123-0311 367 µM 0.493738809606681 0.322287137331882 no 1104 0.31074532639549 1473 693629 YIL048W NEO1 SGTC_566 0958-0068 16.5 µM 0.493345730806552 0.32242879816683 no 1105 0.310884160479046 1505 6815365 SGTC_2731 amoxapine 43.43 µM 0.491994042443232 0.322916126971479 no 1106 0.31136177756215 1562 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1703 st026983 48.3 µM 0.490004939911248 0.323633817934376 no 1107 0.312065201617797 1572 1104023 SGTC_953 1188-0045 9.7 µM 0.489408289231382 0.323849224440642 no 1108 0.312276334347753 1554 6144426 SGTC_2160 5660466 132.927 µM 0.489261148298559 0.32390235524076 no 1109 0.312328411592215 1527 2859134 SGTC_1791 st048313 56.1 µM 0.487038643705943 0.324705310484953 no 1110 0.313115472929395 1581 1204976 SGTC_1790 st045711 43.5 µM 0.486585695573864 0.324869053509359 no 1111 0.313275981290644 1627 585119 SGTC_1473 k844-0725 134 µM 0.486459322139538 0.324914744179928 no 1112 0.313320769757885 1535 54682906 SGTC_1516 st013856 110 µM 0.485651387254395 0.325206917530294 no 1113 0.313607177941768 1481 5281404 A mutagen and neurotoxin. SGTC_705 1124-0212 310 µM 0.485238413628182 0.32535630263699 no 1114 0.313753618092499 1580 9554485 SGTC_1982 st072467 71.9 µM 0.4841042957204 0.325766691848886 no 1115 0.314155926395982 1489 3163533 SGTC_1009 4106-0057 9.87 µM 0.482962356216883 0.32618012479753 no 1116 0.314561232502897 1509 2928005 SGTC_1395 3486-0190 4.35 µM 0.482559009760479 0.326326205276521 no 1117 0.314704444840751 1620 6748079 SGTC_1746 st038117 42 µM 0.482481065749578 0.326354437426887 no 1118 0.314732122883911 1523 2898218 SGTC_207 4185-0010 4.486 µM 0.480758203714506 0.326978730185736 no 1119 0.315344179504994 1548 3761753 SGTC_3206 9114350 49.47 µM 0.478533991878288 0.327785407455444 no 1120 0.316135093331572 1475 17087243 SGTC_1909 st060837 51.5 µM 0.477092199152131 0.328308746864118 no 1121 0.316648234654137 1470 678937 SGTC_284 0988-0104 32.6 µM 0.476109806445238 0.328665527230337 no 1122 0.316998075495251 1561 4666532 SGTC_1353 1498-1206 8.11 µM 0.473657469158466 0.329556835786342 no 1123 0.317872093417432 1513 6756808 SGTC_692 k241-0027 77.8 µM 0.472198289692689 0.330087638703702 no 1124 0.318392630201047 1609 3600480 SGTC_1833 st055984 71 µM 0.471267122867909 0.330426546421251 no 1125 0.318724995285149 1526 676288 SGTC_1414 3917-0015 5.4 µM 0.471175936126726 0.330459742254581 no 1126 0.318757550778024 1528 6618702 SGTC_2003 4023581 200 µM 0.470141733046569 0.330836329259589 no 1127 0.3191268798354 1522 16641307 SGTC_2389 9091542 195.52 µM 0.470073792320182 0.330861074688429 no 1128 0.319151148754121 1508 3626624 YOL127W RPL25 SGTC_3059 1327-0034 3 µM 0.469037423433999 0.33123863340643 no 1129 0.319521443250294 1486 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_160 3453-0671 289.699 µM 0.464740874802263 0.332805732654539 no 1130 0.32105851659549 1456 5322268 SGTC_639 0833-0042 114 µM 0.462705007604729 0.333549306786506 no 1131 0.321787914201719 1503 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3113 9123498 49.47 µM 0.46242603579089 0.333651248672093 no 1132 0.321887916061574 1571 8897275 SGTC_675 1309-0189 238 µM 0.462022970704194 0.333798558415304 no 1133 0.322032423902729 1497 4246530 SGTC_2159 5658611 73.75 µM 0.460654372624679 0.334298936276508 no 1134 0.322523297627804 1554 793844 SGTC_112 phenothiazine 287.218 µM 0.458886514565944 0.334945724913413 no 1135 0.323157831639818 1661 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_923 1900-2434 73.3 µM 0.454560716728818 0.336530424154673 no 1136 0.324712650754007 1497 5910570 SGTC_3049 9092223 49.47 µM 0.454329327372815 0.336615272782329 no 1137 0.32479590533393 1557 8623917 SGTC_1280 0880-0253 10.1 µM 0.453568713930198 0.336894242249919 no 1138 0.325069637972952 1526 6836607 SGTC_1751 st044839 27.194 µM 0.452694997514707 0.337214805145582 no 1139 0.32538419112217 1579 5291326 SGTC_597 k018-0003 82.8 µM 0.45262202111118 0.337241585235268 no 1140 0.325410469533842 1641 6786234 SGTC_1418 3966-3099 2.4 µM 0.450890389116747 0.337877282466166 no 1141 0.326034275348279 1607 740335 SGTC_308 4092-1169 104 µM 0.450734787044056 0.337934428029053 no 1142 0.326090353562763 1565 2268590 YDL196W YDL196W SGTC_658 3253-0951 102 µM 0.449561998117605 0.338365260145729 no 1143 0.326513147334349 1566 1184878 SGTC_2426 5582046 32.21 µM 0.449471278625105 0.338398595405939 no 1144 0.32654586126851 1581 2251934 SGTC_483 fpl-64176 144 µM 0.448336215098904 0.3388157862692 no 1145 0.326955283934463 1563 3423 SGTC_933 2914-0560 114 µM 0.445088642024315 0.340010517920291 no 1146 0.328127848268834 1715 463887 SGTC_1893 st059353 36.1 µM 0.444780305235565 0.340124034022416 no 1147 0.328239264250171 1520 3112488 SGTC_236 1509-0011 5.31 µM 0.444692403301435 0.340156398320209 no 1148 0.328271029981017 1586 3107280 SGTC_293 4049-0273 38.5 µM 0.443572560695702 0.340568812153111 no 1149 0.328675823868547 1540 1380311 SGTC_2730 imipramine 71.33 µM 0.443562161302394 0.340572642919345 no 1150 0.328679583921098 1589 3696 A tricyclic antidepressant. SGTC_2728 chlorpromazine 9.18 µM 0.442623021410471 0.340918656380435 no 1151 0.329019215134612 1591 2726 A thorazine and dopamine antagonist. SGTC_2375 9072683 200 µM 0.442559931159969 0.340941905936103 no 1152 0.329042036201785 1707 16798029 SGTC_536 3852-0578 10.6 µM 0.441518895935938 0.341325627751397 no 1153 0.329418692431399 1661 2869208 SGTC_2044 5102272 200 µM 0.440502912391683 0.341700273856704 no 1154 0.329786451697081 1558 592666 SGTC_459 nigericin 15.3 µM 0.440303805188893 0.341773713354812 no 1155 0.329858542558921 1590 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2972 9093619 59.92 µM 0.438083005351891 0.342593247411659 no 1156 0.330663056724524 1503 25236256 SGTC_1583 clindamycin 39.6 µM 0.437753458837446 0.342714922091081 no 1157 0.330782506116656 1492 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2703 st077852 53.4 µM 0.43725569062502 0.342898738276004 no 1158 0.330962962817373 1588 6281836 SGTC_1868 st057644 42.7 µM 0.437225247777552 0.342909981438799 no 1159 0.33097400058624 1545 688665 SGTC_1409 3909-8004 61.9 µM 0.436979751405963 0.343000653325792 no 1160 0.331063016426526 1584 2119279 SGTC_723 4182-0001 115 µM 0.436008864910969 0.343359330105134 no 1161 0.331415148868688 1545 744821 YLR208W SEC13 SGTC_725 1497-0963 19 µM 0.435959931384902 0.343377411465894 no 1162 0.33143290059974 1710 3549977 SGTC_1874 staurosporine 7.6 µM 0.435751030473197 0.343454606189428 no 1163 0.331508688336702 1637 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2017 5132927 60.65 µM 0.43553136815766 0.343535784595981 no 1164 0.331588387674387 1520 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1069 diphenylcyclopropenone 8.49 µM 0.43285027755665 0.344527189092883 no 1165 0.332561772316617 1599 65057 A dermal irritant. YDR527W RBA50 SGTC_3097 9117246 49.47 µM 0.431197932118169 0.345138720612057 no 1166 0.333162228694631 1560 16423892 SGTC_346 4513-0042 7.16 µM 0.430582922145118 0.345366438650634 no 1167 0.33338583046479 1550 2827372 SGTC_3197 9113331 49.47 µM 0.430173786574323 0.345517959161299 no 1168 0.333534614416805 1689 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_327 1273-0057 3.96 µM 0.429630151244878 0.345719329019501 no 1169 0.333732350311891 1571 3108138 SGTC_2515 chrysin 20.77 µM 0.4294751022102 0.34577676927683 no 1170 0.333788754598316 1659 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_193 1273-0060 1.558 µM 0.42932555440819 0.345832174882848 no 1171 0.333843161185402 1537 2847393 YHR072W ERG7 SGTC_1113 artemisinin 1.17947 µM 0.42902445316549 0.345943739173938 no 1172 0.333952714621865 1687 2240 An anti-malaria and mitochondrial poison. SGTC_2624 nerol 100 µM 0.424308644387804 0.347692784420244 no 1173 0.335670367874554 1677 637566 A natural product oil. SGTC_1645 Cervolide 78 µM 0.423895803133588 0.347846058108239 no 1174 0.335820902519938 1579 23173 A fragrance. SGTC_1340 1486-1359 257 µM 0.422901713736779 0.348215231134101 no 1175 0.336183486210338 1608 4309068 SGTC_1332 1480-0653 17.5 µM 0.421193838122685 0.348849817301918 no 1176 0.336806771754144 1675 5749438 SGTC_1778 st046819 58.9 µM 0.421086726441792 0.348889630329758 no 1177 0.336845876894862 1588 671715 SGTC_771 0250-0039 27.3 µM 0.420896882510265 0.348960198726032 no 1178 0.336915190883179 1601 3005115 SGTC_1431 4049-0260 9.09 µM 0.419959533075448 0.349308704869199 no 1179 0.337257508030871 1617 3854841 SGTC_637 1181-0519 7.26 µM 0.417618681959604 0.350179586834955 no 1180 0.338112967732502 1585 6252091 YGR060W ERG25 SGTC_2485 5633444 17.78 µM 0.416655810423572 0.350538039279896 no 1181 0.338465090433398 1550 5724239 SGTC_182 3448-4371 550.524 µM 0.416309603640018 0.350666955766051 no 1182 0.338591733011984 1758 3491403 SGTC_1669 st015249 58.4 µM 0.414329590625234 0.351404580210675 no 1183 0.339316372913955 1690 722793 SGTC_2906 7926292 26.41 µM 0.414152556672532 0.351470558893545 no 1184 0.33938119232875 1577 2966319 SGTC_1276 0871-0068 94.2 µM 0.414148281210976 0.351472152368228 no 1185 0.339382757809938 1679 3414906 SGTC_2676 harmalol 100 µM 0.411006411396746 0.352643838806056 no 1186 0.340533916736429 1668 5459187 A monoamine oxidase inhibitor SGTC_812 4251-0442 148 µM 0.410921044082357 0.352675694113828 no 1187 0.34056521551789 1631 5723007 SGTC_1007 4101-0031 70 µM 0.410665232719388 0.35277115779073 no 1188 0.340659011898846 1710 1146276 SGTC_1324 1418-0026 34.4 µM 0.410414712553219 0.352864655884406 no 1189 0.340750877747952 1642 1372513 SGTC_1053 3366-3204 134 µM 0.408255973869415 0.353670699025784 no 1190 0.341542879006581 1571 3632071 YPR165W RHO1 SGTC_3029 9088683 49.47 µM 0.407452021592702 0.353971051646875 no 1191 0.341838012836056 1621 25236615 SGTC_1777 st045864 34.765 µM 0.405037410913878 0.354873684132199 no 1192 0.342725005953317 1627 4691462 SGTC_1102 cgs 12066b 26.1 µM 0.404806628336391 0.354959998297623 no 1193 0.342809828092861 1629 6438352 A 5-HT1B full agonist. SGTC_1919 st067113 52.3 µM 0.404750340372597 0.354981051486846 no 1194 0.342830517449195 1595 1268243 SGTC_1411 3909-8223 150 µM 0.403325016033866 0.355514307949453 no 1195 0.343354570460698 1727 X1411 SGTC_3082 9117008 49.47 µM 0.403159349894419 0.355576306981767 no 1196 0.343415500962003 1611 41448529 SGTC_2492 derrusnin 100 µM 0.402812140184833 0.355706259424857 no 1197 0.343543214740553 1564 1715307 Part of coumarin class of compounds. SGTC_1078 idebenone 36.1 µM 0.400460356477921 0.356586917708864 no 1198 0.344408738459349 1631 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1960 st011366 51.8 µM 0.399364180344213 0.356997657909536 no 1199 0.344812441546131 1612 3972846 SGTC_68 0986-0284 82.829 µM 0.399121679497311 0.357088546055683 no 1200 0.34490177438966 1543 423278 YIL048W NEO1 SGTC_1880 MG-132 525 µM 0.398091387495626 0.357474784895287 no 1201 0.345281411332767 1709 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_546 peri-Naphthalide 147 µM 0.395833116578666 0.35832188238851 no 1202 0.34611407224527 1716 223824 A penicillin ester. SGTC_153 4077-0274 519.67 µM 0.394926723829786 0.35866207483488 no 1203 0.346448483489935 1755 3121976 SGTC_1235 benzylparaben 21.5 µM 0.394769200768085 0.358721208728654 no 1204 0.346506613431723 1634 7180 SGTC_565 1418-0001 44.5 µM 0.393891860708018 0.359050622644555 no 1205 0.346830439915025 1708 2862145 SGTC_1502 4534-4282 27.7 µM 0.393240188208455 0.359295373276056 no 1206 0.347071044889467 1656 3278949 SGTC_2592 piperlongumine 83.33 µM 0.391414578347159 0.359981330357804 no 1207 0.34774540910375 1571 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3316 9136639 10.545 µM 0.388818797963734 0.360957448740513 no 1208 0.348705097063562 1707 4903665 SGTC_792 4534-1957 155 µM 0.388716750985651 0.360995841085844 no 1209 0.348742844763758 1678 1717904 SGTC_961 1252-1571 372 µM 0.388636590378125 0.361026000273435 no 1210 0.34877249763343 1756 6813498 SGTC_2537 larixol 68.93 µM 0.388173219259845 0.361200353410441 no 1211 0.348943925154315 1683 6708759 SGTC_2784 7567673 72.73 µM 0.386987675817217 0.361646570285348 no 1212 0.34938266589258 1616 3471247 SGTC_999 SEC7.066 22.7 µM 0.383800607899291 0.362847055937658 no 1213 0.350563118735774 1705 740511 YDR170C SEC7 SGTC_3186 9110464 49.47 µM 0.38347943848624 0.362968107133524 no 1214 0.350682156451273 1703 17018021 SGTC_2682 pyrogallin 40.03 µM 0.38342143335496 0.362989971169063 no 1215 0.350703656943416 1689 822798 An ATP competetive kinase inhibitor. SGTC_2826 7992541 19.48 µM 0.382705904077282 0.363259714321918 no 1216 0.350968918164073 1692 2985066 SGTC_2441 5730946 39.09 µM 0.382081145744905 0.36349529374691 no 1217 0.351200588166493 1740 1774275 SGTC_2845 9003024 42.97 µM 0.381893365046876 0.363566110851197 no 1218 0.351270230952224 1734 2990173 SGTC_1554 st069299 38.7 µM 0.38148321995303 0.363720803702791 no 1219 0.351422360047136 1693 24207999 SGTC_1360 1598-0022 39.8 µM 0.379797179659694 0.364356954202322 no 1220 0.352047988032399 1749 761525 SGTC_568 1193-0097 7.48 µM 0.379742914285299 0.364377434988017 no 1221 0.35206813059611 1667 3646150 SGTC_113 0099-0221 2.5 µM 0.378177346573904 0.36496847657755 no 1222 0.352649426414532 1757 89219 SGTC_854 0422-0053 192 µM 0.378122817442999 0.364989068502622 no 1223 0.352669679310525 1612 3596728 SGTC_3265 9137266 49.47 µM 0.377470011476567 0.365235618908259 no 1224 0.352912173155751 1811 17224265 SGTC_1370 2001-0092 44.6 µM 0.372504144021409 0.367112934545391 no 1225 0.354758763581994 1815 790957 SGTC_1059 3448-6867 171 µM 0.371862582964413 0.367355705779555 no 1226 0.354997582495818 1787 3934407 SGTC_92 0063-0024 660.874 µM 0.37049173935351 0.367874620289071 no 1227 0.355508065201845 1681 3594437 SGTC_2591 skatole 100 µM 0.370277479768717 0.367955747211147 no 1228 0.355587875885717 1665 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_820 1582-0060 59.9 µM 0.3686623672859 0.368567480253818 no 1229 0.356189701209142 1632 3848840 SGTC_607 4491-0986 66.8 µM 0.367405582243888 0.369043725378595 no 1230 0.35665825414802 1781 698981 YDR232W HEM1 SGTC_1509 1326-1131 80 µM 0.366601657096978 0.369348469651055 no 1231 0.356958085986487 1784 768313 SGTC_2678 equilin 100 µM 0.366019229727661 0.369569301967302 no 1232 0.357175363255188 1779 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2069 5228469 200 µM 0.364485952232572 0.370150862830273 no 1233 0.357747580965385 1642 2835210 SGTC_2144 5628481 200 µM 0.362900697253648 0.370752450646275 no 1234 0.358339532936703 1694 2818399 SGTC_1733 st037357 54.9 µM 0.362650957751197 0.370847253055959 no 1235 0.358432819557564 1581 1272339 YGL099W LSG1 SGTC_257 daunorubicin 18.5 µM 0.362443760388717 0.370925912200055 no 1236 0.35851022158329 1815 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2468 5987765 72.9 µM 0.362441962335696 0.370926594825559 no 1237 0.358510893301388 1723 26772094 SGTC_2630 antimycin a 100 µM 0.359927799882767 0.371881485625759 no 1238 0.359450563522377 1614 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3329 9141233 27.5565 µM 0.359091280837371 0.372199374663523 no 1239 0.359763402051091 1771 4909101 YNL103W MET4 SGTC_759 3486-0358 89.3 µM 0.357298872468026 0.372880808189489 no 1240 0.360434036998214 1859 875103 SGTC_3207 9114163 49.47 µM 0.356736467735144 0.373094703999585 no 1241 0.360644551049507 1856 849233 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.35621508112037 0.373293034597587 no 1242 0.360839749316826 1725 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1380 2291-0730 164 µM 0.355844405824314 0.37343405644047 no 1243 0.360978545887287 1664 2999191 SGTC_662 k832-1615 104 µM 0.355617963571305 0.373520213776797 no 1244 0.36106334449175 1745 5878478 SGTC_1792 st045773 43.6 µM 0.355115770755943 0.373711311956338 no 1245 0.361251431147744 1691 2919270 SGTC_3348 9149464 3.537 µM 0.354907153551061 0.373790705672779 no 1246 0.361329574572186 1672 1951442 SGTC_1480 1070-0044 41.2 µM 0.353548524112384 0.37430789188892 no 1247 0.361838628736229 1770 3124987 SGTC_1259 0671-0132 43 µM 0.353467821890539 0.374338619738885 no 1248 0.361868874119673 1686 X1259 SGTC_1925 st057770 10.1 µM 0.353412088280705 0.374359841107623 no 1249 0.361889762330799 1584 5989122 SGTC_2875 9039966 71.43 µM 0.353310367364822 0.374398573781899 no 1250 0.36192788702951 1799 6463691 SGTC_2075 5212009 200 µM 0.351576485408732 0.375058985506322 no 1251 0.362577951310376 1779 780898 SGTC_1284 0929-0043 16 µM 0.34787271405429 0.376470926257326 no 1252 0.363967888978153 1681 1239883 SGTC_1019 4262-0212 3.4 µM 0.346486251146144 0.376999896142711 no 1253 0.364488657533948 1837 4677213 SGTC_2163 5671233 125 µM 0.34642314619796 0.377023977743108 no 1254 0.364512366308696 1815 701023 SGTC_3312 9133330 71.43 µM 0.34630446438267 0.377069269434178 no 1255 0.364556956932773 1790 17617324 SGTC_2477 5967686 25.23 µM 0.344347260876552 0.377816426498664 no 1256 0.365292572975352 1658 776118 SGTC_2227 7312221 64.1025 µM 0.343454886403036 0.378157239972931 no 1257 0.365628137184367 1768 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1348 1493-0373 93.8 µM 0.343377546181947 0.378186782030151 no 1258 0.365657224676629 1738 3010129 SGTC_935 2996-0153 430 µM 0.342901908197119 0.378368479662772 no 1259 0.365836128086599 1859 23738523 SGTC_3166 9102297 49.47 µM 0.34068905716176 0.379214160080902 no 1260 0.366668838746656 1679 25237072 SGTC_403 arphamenine a 50 µM 0.340143017224967 0.37942292808586 no 1261 0.366874413973435 1755 5487158 An arginine aminopeptidase inhibitor. SGTC_651 3253-0966 34.4 µM 0.339798011710702 0.379554852526453 no 1262 0.367004322672305 1704 781462 SGTC_879 0831-1030 162 µM 0.339714363936088 0.379586840173934 no 1263 0.367035821778054 1685 1549252 SGTC_1168 k815-0004 80.5 µM 0.339710482697739 0.379588324413752 no 1264 0.367037283351366 1701 642433 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.339515646625589 0.379662834731932 no 1265 0.367110656019529 1710 4620898 SGTC_552 k242-0005 476 µM 0.338150260399325 0.380185118732915 no 1266 0.367624978328959 1712 4088318 SGTC_887 0885-0007 9.62 µM 0.337898591133413 0.38028141049042 no 1267 0.367719804647921 1792 5719458 SGTC_959 1222-0044 107 µM 0.337489942545772 0.380437780270956 no 1268 0.367873796291658 1873 6083612 SGTC_2250 alverine citrate 130 µM 0.336617738800703 0.380771595211677 no 1269 0.368202541116737 1696 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_164 4100-3994 89.624 µM 0.334867602163377 0.381441685345205 no 1270 0.368862481119186 1872 4615967 SGTC_1569 carminic acid 40.6 µM 0.334426878859851 0.381610485052168 no 1271 0.369028729729535 1856 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_328 k915-0120 63.5 µM 0.333391968611709 0.382006950442979 no 1272 0.369419212427411 1834 6624543 SGTC_3310 9130229 44.1445 µM 0.329264020322568 0.383589560240136 no 1273 0.37097806842292 1816 7761258 SGTC_397 arbidol 50 µM 0.327843639957591 0.38413456928502 no 1274 0.371514944639912 1833 131410 A RNA synthesis inhibitor. SGTC_1070 indatraline 8.81 µM 0.327826913307128 0.384140988775408 no 1275 0.371521268480845 1699 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_343 4130-2827 29.8 µM 0.326722584587168 0.384564887303602 no 1276 0.371938858433639 1696 1118244 SGTC_3154 9100113 49.47 µM 0.326714690343693 0.384567918020472 no 1277 0.371941844099386 1690 25237525 SGTC_950 1165-0508 94.1 µM 0.326391191921642 0.384692119917353 no 1278 0.372064200400269 1683 6148369 SGTC_2589 lobaric acid 100 µM 0.323511165671518 0.385798378940082 no 1279 0.373154076404425 1676 73157 A novel microtubule depolymerizer. SGTC_1005 4092-0690 4.4 µM 0.321746281946255 0.386476755780846 no 1280 0.373822456350216 1713 1529343 SGTC_27 0485-0001 32.618 µM 0.321305472346087 0.386646246140945 no 1281 0.373989454887111 1841 2054479 SGTC_2120 5538279 151.968 µM 0.321298335189222 0.386648990540664 no 1282 0.373992158958364 1768 2058197 SGTC_1677 st019204 53.9 µM 0.320034888874567 0.387134903691948 no 1283 0.374470941402017 1672 3945625 SGTC_2334 9017922 200 µM 0.315900910224517 0.388726037450313 no 1284 0.37603886050939 1875 3163164 SGTC_229 benomyl 22.8748 µM 0.314925879396144 0.38910159197391 no 1285 0.376408965867093 1742 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1708 st033234 31.827 µM 0.313736846087273 0.389559714468441 no 1286 0.376860456768799 1835 674664 SGTC_237 nikkomycin 200 µM 0.312043079410988 0.390212570572551 no 1287 0.377503892034596 1859 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3145 9085516 49.47 µM 0.311806655642304 0.390303723917574 no 1288 0.377593732790837 1700 25236195 SGTC_2610 ononetin 44.17 µM 0.311454967147892 0.390439328812607 no 1289 0.377727386260834 1708 259632 SGTC_339 3091-4833 71.4 µM 0.311302361661743 0.390498174950471 no 1290 0.377785386039764 1796 3240077 SGTC_2133 5320837 200 µM 0.31070310070186 0.390729279972912 no 1291 0.37801316991559 1830 2841355 SGTC_840 0245-0196 390 µM 0.310295645140908 0.390886437284575 no 1292 0.378168071256517 1830 3827528 SGTC_3112 9123419 49.47 µM 0.309483614097302 0.391199694178288 no 1293 0.37847683741482 1794 17015854 SGTC_273 hydroxyurea 18.1 mM 0.308736002292058 0.391488162508093 no 1294 0.378761177463179 1794 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1470 k295-0292 231 µM 0.307034730445568 0.392144825733571 no 1295 0.379408468522723 1858 5045612 SGTC_2697 mebhydrolin 72.4 µM 0.306985389408434 0.392163875164519 no 1296 0.379427246598539 1892 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1452 4194-0072 190 µM 0.306370490251407 0.392401295144572 no 1297 0.379661287069957 1908 1343545 SGTC_324 1315-0088 19.6 µM 0.306250943685916 0.392447458168495 no 1298 0.379706793530391 1809 6787421 SGTC_1486 3970-0793 4.53 µM 0.304408868377782 0.393158968309306 no 1299 0.380408206103099 1880 2844330 SGTC_364 0083-0097 67.7 µM 0.304008325941661 0.393313727024734 no 1300 0.380560774003302 1764 5207356 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.303672357157617 0.393443549237583 no 1301 0.380688759920627 1748 75037 A free radical scavenger. SGTC_11 0438-0307 1.3 µM 0.302979920310263 0.393711152178271 no 1302 0.380952582047489 1892 4011476 SGTC_3315 9136395 68.55 µM 0.301681278629012 0.394213167645803 no 1303 0.381447520612554 1921 16876844 SGTC_1725 st036284 20.55 µM 0.300759673297347 0.394569538998042 no 1304 0.381798880712101 1919 707914 SGTC_3089 9117425 49.47 µM 0.300119786794262 0.394817025712977 no 1305 0.382042893408235 1722 9401657 SGTC_292 k038-0015 474 µM 0.29989112093739 0.394905476325043 no 1306 0.382130103636994 1821 46368540 SGTC_2749 bexarotene 57.39 µM 0.298939153579635 0.395273766533794 no 1307 0.382493236022572 1712 82146 An retinoic acid receptor inhibitor. SGTC_2027 5150920 200 µM 0.298539880086603 0.395428262429289 no 1308 0.382645571539975 1848 786715 SGTC_1613 st002381 52.1 µM 0.298189638789062 0.395563799216662 no 1309 0.382779214669633 1879 551167 SGTC_2020 4017018 200 µM 0.297059249725348 0.396001324595773 no 1310 0.383210637398984 1758 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1553 gossypol 38.6 µM 0.297049544512705 0.396005081637705 no 1311 0.383214342105106 1801 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3171 9103192 49.47 µM 0.29675993015321 0.396117200399251 no 1312 0.383324899577207 1900 13018434 SGTC_1713 st033146 12.748 µM 0.296696645226107 0.396141701114952 no 1313 0.383349059249541 1898 674619 SGTC_2943 9068529 45.32 µM 0.296662495502106 0.396154922327371 no 1314 0.38336209644664 1813 3270634 SGTC_2540 epiandrosterone 100 µM 0.295724873877801 0.396517973179752 no 1315 0.383720099876144 1797 441302 A steroid. SGTC_944 3370-0224 231 µM 0.295624565256757 0.396556818399237 no 1316 0.383758405676896 1725 4580514 SGTC_534 k292-0788 63.4 µM 0.29495690496173 0.396815400690873 no 1317 0.384013400347291 1958 4146317 SGTC_3198 9112019 49.47 µM 0.293770011485084 0.397275191987658 no 1318 0.384466825920345 1801 45595555 SGTC_2692 st077426 47.7 µM 0.29255363549544 0.397746552688621 no 1319 0.384931678675477 1889 25238571 SGTC_401 neomycin 50 µM 0.291506204128349 0.398152564943247 no 1320 0.385332099804934 1822 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2256 7954252 200 µM 0.290435263989491 0.398567803866563 no 1321 0.385741634495906 1790 2972920 SGTC_2698 st077697 67.5 µM 0.289723421472142 0.398843872337597 no 1322 0.386013918359529 1709 3154499 SGTC_2445 5742597 35.57 µM 0.289272958035692 0.399018598305426 no 1323 0.386186252241551 1756 1774255 SGTC_2853 9015042 58.44 µM 0.289136175321773 0.399071657655052 no 1324 0.386238585676708 1725 6457456 SGTC_904 1141-0088 396 µM 0.288441556088763 0.399341135996427 no 1325 0.386504380793174 1743 1378119 SGTC_374 0880-0231 82.3 µM 0.287654109385411 0.399646684870989 no 1326 0.386805760621167 1858 6833587 SGTC_914 3820-6779 408 µM 0.287235351271857 0.399809198465199 no 1327 0.386966059919468 1757 2893481 SGTC_903 1134-0042 114 µM 0.286924944569608 0.399929673743155 no 1328 0.387084895081261 1794 701009 SGTC_75 0159-0059 199.013 µM 0.286661456121447 0.400031946549139 no 1329 0.387185776506667 1900 5377270 SGTC_2493 resveratrol 26.09 µM 0.285998420529212 0.400289333545171 no 1330 0.387439665644255 1756 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3216 9129716 49.47 µM 0.285683634015777 0.400411547215444 no 1331 0.387560220344093 1747 8056934 SGTC_2526 patulin 37.61 µM 0.28550286926526 0.40048173227861 no 1332 0.387629453243725 1825 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2835 9006588 71.43 µM 0.284538356563013 0.400856275400189 no 1333 0.387998921955026 1760 2345538 SGTC_671 0560-0003 407 µM 0.282525948988942 0.401638034046167 no 1334 0.388770126127079 1869 3238678 SGTC_1481 3346-2004 36 µM 0.281950995666389 0.401861458250965 no 1335 0.388990543089395 1824 2770522 SGTC_1591 genipin 88.4 µM 0.281793491632472 0.401922669191215 no 1336 0.389050930856622 1882 442424 A DNA cross-linking agent. SGTC_3244 9134489 49.47 µM 0.281095275216716 0.402194046642894 no 1337 0.389318662482699 1784 16584271 SGTC_323 4013-0906 34.3 µM 0.281058565305458 0.402208316078139 no 1338 0.389332740381818 1940 2910086 SGTC_1328 1441-0025 69.2 µM 0.280207371810114 0.40253921828518 no 1339 0.389659205623028 1714 4562601 SGTC_396 dithiazanine 1.25 µM 0.279443173677209 0.402836360475878 no 1340 0.389952371166585 1773 10578 An antihelmenthic. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.279372513408826 0.402863838055873 no 1341 0.389979481379988 1788 279621 SGTC_2534 helenine 20.12 µM 0.279190340117599 0.402934681793639 no 1342 0.390049378244504 1786 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2869 9037858 32.47 µM 0.277429284213297 0.403619686999881 no 1343 0.390725249106722 1790 27187042 SGTC_54 0159-0055 9 µM 0.277213170673776 0.403703769994413 no 1344 0.390808213527363 1934 3319099 SGTC_1965 Pectolinarigenin 58.4 µM 0.276704225235014 0.403901802264402 no 1345 0.391003613620146 1794 5320438 An anti-inflammatory. SGTC_1826 st055655 41.6 µM 0.276002324500368 0.40417495445022 no 1346 0.391273140431774 1824 676168 SGTC_1934 st074720 32.6 µM 0.275783002711413 0.404260315459885 no 1347 0.391357369752801 1724 17250992 SGTC_1293 1000-1278 195 µM 0.275407312076827 0.404406546504911 no 1348 0.391501663501075 1884 678847 SGTC_1274 0865-0114 173 µM 0.274338288705784 0.404822718262194 no 1349 0.39191233132273 1836 870624 SGTC_1429 4049-0205 9.46 µM 0.273272836045395 0.405237607085008 no 1350 0.392321747301061 1857 22774478 SGTC_2251 lansoprazole 556 µM 0.273154097523258 0.405283850644168 no 1351 0.392367381729879 1746 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3266 9136860 49.47 µM 0.272260803715336 0.405631792601612 no 1352 0.392710746138224 1811 4871271 YPR165W RHO1 SGTC_2440 5628896 157.78 µM 0.27218335385247 0.405661963188748 no 1353 0.39274052026635 1819 5522048 SGTC_3078 9116413 49.47 µM 0.272028422098976 0.405722318521147 no 1354 0.392800082718535 1823 17177322 SGTC_816 0325-0417 81.3 µM 0.271921356839959 0.405764028255008 no 1355 0.392841244691424 1792 68101 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.271724411143237 0.40584075577413 no 1356 0.392916964944209 1907 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2154 5570129 200 µM 0.271694333143303 0.405852474095861 no 1357 0.392928529472193 1901 673366 SGTC_3006 9075424 71.4286 µM 0.270931559362418 0.40614967723002 no 1358 0.393221835811027 1778 7465181 SGTC_1561 5-methoxyflavone 52.9 µM 0.27025765164613 0.406412300071016 no 1359 0.393481021282393 1943 94525 SGTC_1039 k821-0043 94 µM 0.269789975532705 0.406594578905842 no 1360 0.39366091766256 1934 15992768 SGTC_1206 3978-0017 132 µM 0.268166603398353 0.407227452204291 no 1361 0.394285540204263 1895 3873677 SGTC_146 3448-8650 53.125 µM 0.262120142540437 0.409586790294128 no 1362 0.396614409025311 1861 2891488 YIL048W NEO1 SGTC_1243 0416-0003 5.65 µM 0.261778985958314 0.409720008595989 no 1363 0.396745920516356 1819 2141977 SGTC_1937 st074714 47.2 µM 0.260596754988664 0.410181738754701 no 1364 0.397201746191633 1723 17250970 SGTC_9 0092-0002 10.449 µM 0.260452443180932 0.410238109476273 no 1365 0.397257397257063 1874 759368 SGTC_2357 9067248 200 µM 0.260143984818844 0.410358604936835 no 1366 0.397376355287834 1864 9150235 SGTC_1701 st028638 40.4 µM 0.260139625411503 0.410360307946301 no 1367 0.397378036576739 1930 3490878 SGTC_1816 st051957 91.6 µM 0.259593280559407 0.4105737518089 no 1368 0.397588760012372 1865 674121 SGTC_708 3448-5400 146 µM 0.259132290262865 0.410753870295249 no 1369 0.397766585724518 1941 3462195 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.257690261946575 0.411317422072872 no 1370 0.398322981098933 1773 23665772 A membrane-active detergent. SGTC_2467 5474540 200 µM 0.255705287209035 0.412093459160703 no 1371 0.399089206134006 1825 5413519 SGTC_1290 0986-0249 10.2 µM 0.255603762024963 0.412133160274561 no 1372 0.399128406603949 1950 53329 SGTC_1775 st081588 35.1725 µM 0.25546436916524 0.412187670892444 no 1373 0.399182230035993 1822 1426443 YGL099W LSG1 SGTC_1621 st003705 32.4 µM 0.25532396988867 0.412242576789708 no 1374 0.399236444010859 1974 24207032 SGTC_1229 0139-0193 12.2 µM 0.252638746894272 0.413293015405108 no 1375 0.400273692679793 1983 3090752 SGTC_2852 9023854 51.95 µM 0.2520132188756 0.413537806616638 no 1376 0.400515423156687 1908 19798528 SGTC_1652 st011932 78 µM 0.251726580335904 0.413649989637957 no 1377 0.400626205147006 1947 1551076 SGTC_154 3389-1638 511.116 µM 0.250422148122439 0.414160600062466 no 1378 0.401130451715575 1729 5238686 SGTC_2725 haloperidol 53.21 µM 0.248023674832553 0.415099843006301 no 1379 0.402058044565207 1914 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3015 9080845 49.47 µM 0.24684290455978 0.415562411696642 no 1380 0.402514902315469 1970 5296973 SGTC_753 1322-0200 289 µM 0.246678081178206 0.415626990849893 no 1381 0.402578685563206 1890 5403907 SGTC_1547 harmine 94.2 µM 0.243018058166679 0.417061601967552 no 1382 0.403995704164962 1866 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_21 0849-0113 22.993 µM 0.239267677986373 0.418532776453243 no 1383 0.405449013403641 1853 1560156 SGTC_1368 1852-0141 284 µM 0.239233391914364 0.418546231259218 no 1384 0.405462305641767 1885 2838987 SGTC_1130 3454-2858 15.9 µM 0.239174293525173 0.418569423330601 no 1385 0.405485217529615 1793 715628 YIL048W NEO1 SGTC_789 1309-1135 70.6 µM 0.238566973397812 0.418807771284907 no 1386 0.405720688563438 1807 3092424 SGTC_905 2-aminofluorene 215 µM 0.234514450561383 0.42039897730862 no 1387 0.407292808012202 1869 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1144 3486-0183 12.5 µM 0.231571456405746 0.421555349055498 no 1388 0.408435439699814 1906 6744069 SGTC_620 0109-0052 432 µM 0.231335364257956 0.421648144681553 no 1389 0.40852713749265 2003 493037 SGTC_2140 5586273 200 µM 0.231170518568019 0.421712939585855 no 1390 0.408591166250771 1948 854421 SGTC_539 4859-0462 2.54 µM 0.229010840547556 0.422562026395231 no 1391 0.409430245238647 2028 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_710 3448-4187 58 µM 0.228987165642102 0.422571336288987 no 1392 0.409439445729541 1903 3946412 SGTC_2858 9025781 8.96 µM 0.227122726495612 0.423304641699447 no 1393 0.410164156299562 2010 4894980 YPL153C RAD53 SGTC_2456 5770359 74.46 µM 0.226827724659681 0.423420693738646 no 1394 0.410278852186783 1996 3118787 SGTC_992 3909-8734 162 µM 0.226463325053196 0.423564055635804 no 1395 0.410420540327467 1863 4288319 SGTC_393 acivicin 6.25 µM 0.226453882192456 0.423567770775581 no 1396 0.410424212115317 1906 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2774 tamoxifen 10.92 µM 0.226073323268967 0.423717501137664 no 1397 0.410572196221223 1944 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_799 1310-0557 151 µM 0.224432083510484 0.424363370481199 no 1398 0.411210554158083 1919 5354492 SGTC_1782 st039423 80.636 µM 0.224285646135718 0.424421007188416 no 1399 0.411267522224748 1850 2068169 SGTC_2354 9060492 162 µM 0.222617264823064 0.425077783993431 no 1400 0.411916699117528 2001 6471895 SGTC_2767 sibutramine 71.45 µM 0.222201917225156 0.425241322589325 no 1401 0.412078350846817 2024 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1709 st033179 39.1045 µM 0.222017909754136 0.425313777641975 no 1402 0.412149970635839 1913 573381 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.221369032156222 0.425569300755781 no 1403 0.412402551524979 1885 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1483 3453-0561 55.9 µM 0.220713029932485 0.425827661273413 no 1404 0.412657942615817 1985 4546991 SGTC_157 1348-1695 65.819 µM 0.218687512216072 0.42662559351977 no 1405 0.413446738676202 1887 5380510 SGTC_1298 1079-1278 263 µM 0.217211802030892 0.427207123988882 no 1406 0.414021643778804 1920 2840950 SGTC_67 0335-0847 266 µM 0.21608713619112 0.427650425350837 no 1407 0.414459913340851 2073 4552207 YOR254C SEC63 SGTC_1355 1499-0035 1.68 µM 0.215149658815509 0.428020013831074 no 1408 0.414825319101843 1882 1548538 SGTC_1141 3253-0389 52.6 µM 0.215109031078009 0.428036032227753 no 1409 0.414841156469229 2029 5402031 SGTC_806 3966-4455 5.86 µM 0.214675366728458 0.428207021507195 no 1410 0.415010214659619 1873 714982 SGTC_3193 9111931 49.47 µM 0.212380013491228 0.429112278837576 no 1411 0.415905288525618 1926 17087244 SGTC_1884 5633444 25 µM 0.211044588174242 0.429639125067823 no 1412 0.416426239248904 1961 5724239 SGTC_1694 st024011 44.9 µM 0.210716778235182 0.429768470424484 no 1413 0.416554140708124 2023 2787533 SGTC_59 0330-0160 1.33 µM 0.210149426785227 0.429992350497048 no 1414 0.416775524843452 1971 4293482 SGTC_1623 st003709 20.3 µM 0.209540011890122 0.430232854116508 no 1415 0.417013351805111 1869 16192618 SGTC_802 4112-3352 742 µM 0.20866240913076 0.430579242667608 no 1416 0.417355893652076 2024 704594 SGTC_2128 5255449 168.493 µM 0.207940380519869 0.430864266392539 no 1417 0.41763775956615 1940 736008 SGTC_2837 9008476 45.46 µM 0.207430041486741 0.431065746529893 no 1418 0.417837011526979 1969 2992805 SGTC_834 0312-0008 75.7 µM 0.206714901590831 0.431348111534153 no 1419 0.41811625948466 1932 6385573 YIL048W NEO1 SGTC_124 0136-0217 7.121 µM 0.204833898238861 0.432090971862788 no 1420 0.418850950765639 2103 3976905 SGTC_2877 9040724 71.43 µM 0.204795832815376 0.432106007441013 no 1421 0.418865821471857 2092 6463895 SGTC_573 3702-0553 84.7 µM 0.20381947309094 0.432491696308484 no 1422 0.419247287465741 1938 1222756 SGTC_899 1083-0020 478 µM 0.203564996726918 0.432592232035144 no 1423 0.419346724454066 2025 767123 SGTC_2675 theaflavin digallate 100 µM 0.20331898488243 0.432689427841208 no 1424 0.419442858816889 1969 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2254 7938975 95.19 µM 0.202553699350574 0.432991807363836 no 1425 0.419741941142615 2037 2969277 SGTC_1048 3161-0300 24.5 µM 0.202315900334269 0.433085774479872 no 1426 0.419834885163694 1991 2165101 SGTC_1037 k284-1091 78.7 µM 0.201747398901459 0.433310435141185 no 1427 0.420057102721847 1904 3334711 SGTC_1304 1165-0502 251 µM 0.201136391233634 0.43355191746417 no 1428 0.420295963661957 1986 767425 SGTC_3054 9094397 49.47 µM 0.19978283865278 0.43408695645346 no 1429 0.420825211762621 1935 2598354 SGTC_1737 st035557 69.7 µM 0.199025045520865 0.434386553487254 no 1430 0.421121576498955 1879 5716916 SGTC_1065 prochlorperazine maleate 2.48 µM 0.198702086162732 0.434514248432766 no 1431 0.421247896021827 1996 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2037 5169046 200 µM 0.198625489992025 0.4345445348062 no 1432 0.421277856373628 1984 5718022 SGTC_3009 9080819 71.4286 µM 0.198214584267278 0.43470701481121 no 1433 0.421438588635742 1920 17027216 SGTC_2398 5228213 48.84 µM 0.19708495901495 0.435153747053349 no 1434 0.421880526777356 2095 80771 YMR134W ERG29 SGTC_601 0986-0029 62.9 µM 0.196202098730317 0.435502948959696 no 1435 0.42222599271746 1959 24747981 SGTC_2214 7179297 48.276 µM 0.196012996460041 0.435577752025428 no 1436 0.42229999680743 2013 769744 SGTC_288 1315-0019 35.1 µM 0.195902614027778 0.435621417000125 no 1437 0.422343195607932 1965 6811474 SGTC_569 4130-2812 160 µM 0.195216315003092 0.435892920087583 no 1438 0.422611803623223 2092 743552 SGTC_1222 0366-0074 1.18 µM 0.194901647303963 0.436017414203755 no 1439 0.422734972281097 2074 286520 SGTC_382 3229-0966 23.2 µM 0.194187937009799 0.436299807726378 no 1440 0.423014363980527 2045 5722370 SGTC_721 1187-1332 279 µM 0.193724328378113 0.436483261011246 no 1441 0.423195870704116 1975 25730 SGTC_2580 diallyl disulphide 81.36 µM 0.191908496879689 0.437201929849459 no 1442 0.423906940803547 1931 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1818 st052136 56.3 µM 0.190386767783922 0.437804358724027 no 1443 0.424503032909593 1982 674169 SGTC_1629 st005085 44.9 µM 0.19024062841728 0.437862220636262 no 1444 0.42456028777056 1907 24207091 SGTC_560 2332-1943 155 µM 0.189453272637771 0.438173986375566 no 1445 0.424868787425976 2004 21177716 SGTC_1822 st052468 42 µM 0.188841413173784 0.438416288134299 no 1446 0.425108556367325 1980 2873678 SGTC_1250 0485-0349 40.2 µM 0.188352230458076 0.438610025427218 no 1447 0.425300271991122 1952 6842794 YDL195W SEC31 SGTC_423 5-fluorouracil 457 µM 0.188312287176401 0.438625845326634 no 1448 0.425315926945438 1834 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1399 3562-5772 25 µM 0.188291098623562 0.438634237285196 no 1449 0.425324231414228 1992 23847490 SGTC_2664 lyso-paf C-16 73.48 µM 0.188221838657384 0.4386616686463 no 1450 0.425351376832289 2013 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1697 st025554 27.742 µM 0.187616234715295 0.438901538945275 no 1451 0.425588749390245 1962 1269519 SGTC_3246 9135460 32.98 µM 0.18746649926135 0.43896085029246 no 1452 0.425647443869979 2033 41446951 SGTC_1326 1431-2094 10.8 µM 0.187106442058126 0.439103477285022 no 1453 0.425788588663406 1899 616278 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.186547251748665 0.439325001178987 no 1454 0.426007813790705 2072 688801 SGTC_349 k015-0014 24 µM 0.186380125238659 0.43939121223254 no 1455 0.426073338557008 1912 2196908 SGTC_2997 9067075 71.4286 µM 0.185448011628129 0.439760521765098 no 1456 0.426438826802425 2011 27209819 SGTC_634 1611-4317 11.2 µM 0.18492026373168 0.439969642211738 no 1457 0.426645788465587 2117 2843522 SGTC_1459 k035-0031 35.7 µM 0.183530301838212 0.440520495511274 no 1458 0.427190972558396 1884 3877128 YMR208W ERG12 SGTC_1496 4469-0713 57.4 µM 0.182772942031409 0.440820691938865 no 1459 0.427488090043141 2072 746691 SGTC_106 0092-0003 11.579 µM 0.181399360733577 0.44136522814099 no 1460 0.428027060307691 2089 1072148 SGTC_2691 st077356 60.2 µM 0.181340268524813 0.441388656876772 no 1461 0.428050250119734 2034 2839272 SGTC_2191 5911152 200 µM 0.178646465324969 0.442456905949856 no 1462 0.429107653638114 2002 2875902 SGTC_1394 3474-0001 65.7 µM 0.17707392557462 0.443080703065427 no 1463 0.429725161320263 1987 5017666 YIL048W NEO1 SGTC_2602 kawain 100 µM 0.176983808666381 0.443116455047399 no 1464 0.429760553810746 2130 5369129 SGTC_2876 9059903 25.97 µM 0.176950123374796 0.443129819095037 no 1465 0.429773783508123 2095 6916095 SGTC_1498 4478-3555 97.6 µM 0.176220832862657 0.443419168130194 no 1466 0.430060227317802 2110 3437919 SGTC_2636 apigenin dimethyl ether 100 µM 0.175846209215278 0.443567813355531 no 1467 0.430207382762631 2016 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1435 4092-0789 56.7 µM 0.174766030703583 0.443996456893959 no 1468 0.430631740532753 2100 2248285 SGTC_2201 6605497 169.863 µM 0.174094507862361 0.444262968063085 no 1469 0.430895594691039 2069 670741 SGTC_1478 0453-0656 35.7 µM 0.174028261814376 0.444289260884612 no 1470 0.43092162570297 2069 5258496 SGTC_1504 k297-0033 30 µM 0.172077260174257 0.445063715968742 no 1471 0.43168839491964 1924 4388117 SGTC_1682 st012968 530 nM 0.17150915183345 0.44528926758341 no 1472 0.431911717470388 1923 24207270 SGTC_3011 9081274 71.4286 µM 0.171008599233205 0.445488012750286 no 1473 0.432108501994536 1994 6625322 SGTC_2551 apiole 73.87 µM 0.170214886290905 0.445803185740589 no 1474 0.432420572493399 2096 10659 A possible DNA adduct former. SGTC_582 0987-0078 156 µM 0.168845223206511 0.44634714140935 no 1475 0.432959192990505 2101 1625765 SGTC_2358 9037157 4 µM 0.167084913403274 0.447046388855427 no 1476 0.433651618251827 2028 2388925 SGTC_2072 5231554 129 µM 0.167054432658759 0.44705849817076 no 1477 0.433663609780851 2158 789545 SGTC_453 enantio-paf c16 10 µM 0.166187072260485 0.447403101622452 no 1478 0.434004866410357 2086 13871343 A lipid and platelet activating factor SGTC_1258 0671-0043 57.1 µM 0.165706474591486 0.447594060835525 no 1479 0.434193975258377 1973 4298767 SGTC_120 rhodamine 6G 52.259 µM 0.16227899615569 0.44895627431634 no 1480 0.435543077038238 2133 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3289 9119912 71.43 µM 0.161250228610187 0.449365264804179 no 1481 0.435948160990822 2039 17014829 SGTC_897 1000-0139 31.4 µM 0.159603946119866 0.450019862486933 no 1482 0.436596535139988 2134 6151020 SGTC_87 0100-0052 35.5 µM 0.159545123218482 0.450043254277668 no 1483 0.436619705194914 2057 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1128 3448-9350 235 µM 0.15905486410024 0.450238219760989 no 1484 0.436812824329693 1961 619386 SGTC_1331 1472-0049 76.2 µM 0.159032404724782 0.450247151658531 no 1485 0.436821671716771 1979 24051409 SGTC_2264 7948757 110.76 µM 0.158936509438583 0.450285288660108 no 1486 0.436859447954181 1929 2971411 SGTC_2172 5754775 163.918 µM 0.158148690098954 0.450598617208352 no 1487 0.437169817094024 1997 2263357 SGTC_302 1094-0063 18.9 µM 0.157510386141034 0.450852503649637 no 1488 0.437421311554072 2013 5440289 SGTC_526 4469-0568 170 µM 0.157493361694394 0.45085927542687 no 1489 0.437428019604727 1931 2901964 SGTC_2958 9077254 16.72 µM 0.156251624156041 0.451353237118422 no 1490 0.437917343108671 2014 16457351 SGTC_2374 9071832 200 µM 0.155682503623145 0.451579657801487 no 1491 0.438141644542882 2124 17381698 SGTC_902 1120-0002 2.07 µM 0.155221686247534 0.45176300236432 no 1492 0.438323276167869 2111 3280475 SGTC_1794 st048918 76.9 µM 0.155196798346017 0.451772904761182 no 1493 0.438333086129034 2135 672303 SGTC_2012 4023501 200 µM 0.153273156052697 0.452538373767735 no 1494 0.439091434443523 2006 3477460 SGTC_3132 9126706 49.47 µM 0.152111694665798 0.453000636098394 no 1495 0.439549420267219 2065 850858 SGTC_2813 7971799 71.43 µM 0.151396351556536 0.453285374824251 no 1496 0.439831533663585 2039 2234054 SGTC_1911 st060208 74.3 µM 0.151371637556708 0.453295212537623 no 1497 0.439841280792658 2106 688783 SGTC_2304 7443016 91.4 µM 0.150966949038669 0.453456307881756 no 1498 0.440000893940638 2074 939854 SGTC_736 0958-0254 92.6 µM 0.150853099006983 0.453501629822797 no 1499 0.440045799276183 2081 6812352 SGTC_2161 5662504 8.5105 µM 0.150594767924718 0.453604469686061 no 1500 0.440147694456287 2037 2859334 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.148350535136949 0.454498013817238 no 1501 0.441033067632329 2109 368090 SGTC_2721 ifenprodil 61.44 µM 0.148114166270927 0.454592137865486 no 1502 0.441126334844841 2117 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1263 0774-1208 64.8 µM 0.146818401750286 0.455108167235382 no 1503 0.441637679793757 2163 906585 SGTC_16 erodoxin 22.806 µM 0.146330932782692 0.455302318080287 no 1504 0.44183007392267 2108 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_516 3992-2719 87.3 µM 0.146312040496861 0.455309842781143 no 1505 0.441837530601811 2047 5350887 YDR037W KRS1 SGTC_1093 fluphenazine 7.97 µM 0.146292308727075 0.455317701861285 no 1506 0.441845318642561 2047 6602611 An atypical antipsychotic. SGTC_3128 9127691 49.47 µM 0.146276800167942 0.455323878866825 no 1507 0.441851439816847 2071 41316314 SGTC_2593 nobiletin 86.24 µM 0.145659955465607 0.455569574724129 no 1508 0.442094917517973 2008 72344 An anti-infammatory. SGTC_1936 st074407 74.3 µM 0.145261675425511 0.455728222967916 no 1509 0.442252136152325 1979 809813 SGTC_2267 7931562 200 µM 0.144963420894815 0.455847032334249 no 1510 0.442369876280137 1899 934880 SGTC_762 1165-0429 115 µM 0.144882544383537 0.455879250085058 no 1511 0.442401804286605 2162 5967793 SGTC_1749 st037932 54.2 µM 0.144358187986239 0.456088138326258 no 1512 0.442608816031662 2045 594497 SGTC_3327 9140648 26.9345 µM 0.143372875582964 0.456480690735898 no 1513 0.442997851895037 2136 8029710 SGTC_1672 st016598 6.51 µM 0.140969128353216 0.457438530717165 no 1514 0.443947165382365 2000 4665860 YNL267W PIK1 SGTC_807 1315-0151 48 µM 0.139313976225734 0.458098216240362 no 1515 0.444601023074114 2184 4011080 SGTC_965 1291-5240 308 µM 0.137602103439817 0.458780630049772 no 1516 0.445277446520073 2139 2834598 SGTC_1990 st072050 59.8 µM 0.135718151035349 0.459531781308593 no 1517 0.44602204901958 2005 17233948 SGTC_377 3970-0964 33.1 µM 0.135042524052042 0.459801196094189 no 1518 0.446289126459668 2095 16481235 SGTC_365 0121-0052 13.6 µM 0.134135803372873 0.460162791395156 no 1519 0.446647594229489 2106 3101739 SGTC_277 nystatin 15.5 µM 0.134073369525133 0.460187690891737 no 1520 0.446672278766277 2151 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2966 9084041 48.03 µM 0.133803811398607 0.460295196254759 no 1521 0.446778856620191 1930 17741380 SGTC_3099 9120367 49.47 µM 0.132158049098984 0.460951623010239 no 1522 0.447429640985932 2159 24824940 SGTC_3217 9129673 49.47 µM 0.131917223490388 0.461047687388245 no 1523 0.447524882655492 2097 17248312 SGTC_493 zm226600 134 µM 0.129913097362863 0.461847212975383 no 1524 0.448317590955867 2122 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2508 celastrol 40.54 µM 0.129644333621891 0.461954445313773 no 1525 0.448423913029049 2175 122724 Celastrol is a natural product and antioxidant. SGTC_954 1189-0853 2.85 µM 0.129315408615662 0.46208568477605 no 1526 0.448554039746334 2200 2828194 SGTC_495 decylubiquinone 155 µM 0.129249187454951 0.462112107193652 no 1527 0.448580238309555 2038 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.129160518336201 0.462147486667467 no 1528 0.448615318135095 2034 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3296 9122258 64.045 µM 0.128934481230798 0.462237678089738 no 1529 0.448704746150552 2079 4730474 SGTC_57 miconazole 162.5 nM 0.128446335737745 0.462432460411912 no 1530 0.448897882101375 2143 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1853 st056710 91.2 µM 0.127890805764362 0.462654141793486 no 1531 0.449117693616124 2215 269167 SGTC_42 0133-0086 60.653 µM 0.126406194670098 0.463246624956879 no 1532 0.449705199425015 2157 162923 Model of phenazepam hydroxylation. SGTC_3264 9137442 49.47 µM 0.126169511878705 0.463341088622972 no 1533 0.449798872234973 2181 17015726 SGTC_2705 st078069 42.8 µM 0.125732195763558 0.463515633503865 no 1534 0.44997195778124 2096 1530061 SGTC_2947 9072639 7.68 µM 0.1246415424138 0.463950973759499 no 1535 0.450403669367555 2086 16488146 SGTC_47 0149-0135 24.25 µM 0.124234024548809 0.464113647851842 no 1536 0.450564991606883 2177 5239155 SGTC_1188 1403-0014 4.57 µM 0.122699153121821 0.464726395639853 no 1537 0.451172667255194 2066 9614867 SGTC_1696 st025591 34.7925 µM 0.122337507893332 0.464870783035666 no 1538 0.451315864038347 2176 2787147 SGTC_2314 7727897 200 µM 0.122276461254222 0.464895156454032 no 1539 0.451340036646921 2099 900724 SGTC_3248 9135562 49.47 µM 0.12094722589692 0.465425898097267 no 1540 0.451866417923506 2079 17650701 SGTC_93 0109-0045 59.227 µM 0.120547611586567 0.46558546953493 no 1541 0.452024683003467 2216 88733 SGTC_2325 6158266 200 µM 0.120123487004438 0.465754834310518 no 1542 0.452192663583058 2094 3623240 SGTC_123 0083-0120 66.675 µM 0.11926334795242 0.466098330838598 no 1543 0.452533360148553 2005 16001701 SGTC_432 NS 1619 61.3 µM 0.11811376431065 0.46655745645327 no 1544 0.452988758726508 2068 4552 A K+/calcium channel activator. SGTC_2180 6301957 200 µM 0.117431026219203 0.466830152406532 no 1545 0.453259249394141 2189 845462 SGTC_2056 5235370 200 µM 0.115374135811968 0.467651799247363 no 1546 0.454074289337862 2088 5511916 SGTC_290 2043-6722 48.1 µM 0.115240960685656 0.467705002262605 no 1547 0.454127066499478 2176 773758 YLR208W SEC13 SGTC_1336 1486-0901 104 µM 0.114606279258816 0.467958563268567 no 1548 0.454378601189874 2118 5006114 SGTC_2247 cerulenin 830 nM 0.114131837237531 0.468148115670633 no 1549 0.454566642324163 2174 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2444 5485484 36.41 µM 0.114042368580105 0.468183861626427 no 1550 0.454602103622019 2163 6790631 SGTC_2272 7805186 180 µM 0.114010041562277 0.468196777499195 no 1551 0.454614916667433 2220 2956062 YPR165W RHO1 SGTC_572 0960-0087 17.7 µM 0.113576435629115 0.468370022786693 no 1552 0.454786784049 2151 6796365 SGTC_1991 st073000 8.92 µM 0.112951178125553 0.468619852129742 no 1553 0.45503463081504 2178 4301969 YIL048W NEO1 SGTC_830 4076-0286 57.8 µM 0.112550993249282 0.468779757422055 no 1554 0.45519326989546 2126 6866659 SGTC_2108 5365811 200 µM 0.112208240401681 0.468916718112831 no 1555 0.455329147769776 2160 780283 SGTC_1149 3909-7961 23.3 µM 0.111700534792731 0.469119599071413 no 1556 0.455530427640933 2048 735261 SGTC_798 1287-0182 476 µM 0.111377094045823 0.469248851323519 no 1557 0.455658661669605 2207 1649755 SGTC_378 3970-0959 8.33 µM 0.110926403985367 0.469428959899279 no 1558 0.455837353727728 2132 6615653 SGTC_2070 5230947 200 µM 0.110341825753968 0.469662583312851 no 1559 0.456069143803047 2212 2835538 SGTC_2587 piperic acid 92.2 µM 0.110156736748482 0.469736555277249 no 1560 0.456142536235741 2112 5370536 SGTC_3027 9089541 49.47 µM 0.108406610129511 0.470436055468839 no 1561 0.456836578956998 2128 9943819 SGTC_1388 3346-4487 254 µM 0.10735206739633 0.470857585071044 no 1562 0.457254839676446 2150 3345614 SGTC_2306 7482397 179.52 µM 0.106895711394537 0.471040013210208 no 1563 0.457435857754492 2196 891448 SGTC_604 1000-0114 314 µM 0.106840253724379 0.471062182807779 no 1564 0.457457856185076 2220 1572745 SGTC_2192 5915882 198.485 µM 0.106272166696786 0.471289284784516 no 1565 0.457683207135148 2203 2876149 SGTC_1146 3579-1023 7 µM 0.106173749881459 0.471328629449013 no 1566 0.457722248881186 2205 X1146 SGTC_2455 5377712 9.75 µM 0.105876242456262 0.471447567428224 no 1567 0.457840271937346 2040 2243908 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.104623067516676 0.471948591477695 no 1568 0.458337454962855 2168 688761 SGTC_96 0929-0093 37.281 µM 0.104597077674217 0.471958982786988 no 1569 0.458347766832456 2089 6991579 SGTC_1082 camptothecin 424.86 nM 0.103993193050869 0.472200434469601 no 1570 0.458587375220192 2203 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1076 itraconazole 331 nM 0.103914760412491 0.472231795007038 no 1571 0.458618496704625 2225 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2331 7980721 200 µM 0.103910907920847 0.472233335393272 no 1572 0.45862002535104 2176 2981221 SGTC_2929 9013348 24.6 µM 0.102226596411301 0.472906832582011 no 1573 0.459288408727404 2149 2995952 SGTC_2694 st077685 81.9 µM 0.100935672681614 0.473423080312996 no 1574 0.459800762498317 2163 2838096 SGTC_1844 rapamycin 4 nM 0.0988173616881074 0.474270301234877 no 1575 0.460641641664828 2108 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1163 k060-0048 49.9 µM 0.0987897129787993 0.47428136014574 no 1576 0.460652618195788 2220 6809982 SGTC_982 1491-0518 27.5 µM 0.0985718060811362 0.47436851908284 no 1577 0.460739128230489 2146 3091256 SGTC_2288 7946289 167.31 µM 0.0982429950920264 0.474500040032286 no 1578 0.460869671212758 2220 1246052 SGTC_3263 9137018 49.47 µM 0.0980744943348006 0.474567439647043 no 1579 0.460936570220813 2061 43844957 SGTC_646 4092-0839 27.3 µM 0.0968172998625277 0.475070335146368 no 1580 0.461435742586434 2202 877796 SGTC_2124 5246320 200 µM 0.0957987213541634 0.475477810063499 no 1581 0.461840216450936 2163 579342 SGTC_3085 9117376 49.47 µM 0.0947515267693421 0.475896759369118 no 1582 0.46225609480125 2143 16480349 SGTC_1384 3089-0840 101 µM 0.0945988784857258 0.475957831337229 no 1583 0.462316720340498 2227 1069836 SGTC_60 0986-0278 202 µM 0.094249762395123 0.476097508836165 no 1584 0.462455377996724 1989 3110598 SGTC_1479 0549-0158 134 µM 0.0938141691311361 0.476271789015365 no 1585 0.462628387994051 2205 5440202 SGTC_2018 5133068 143 µM 0.0936432199479607 0.476340186756544 no 1586 0.462696287942098 2211 785362 SGTC_2064 5220758 200 µM 0.0919684307426909 0.477010316007425 no 1587 0.463361560939658 2151 788518 SGTC_2429 5902844 64.44 µM 0.0908757459810434 0.477447564417099 no 1588 0.463795661168394 2221 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_135 0933-0004 26.348 µM 0.0902415070952628 0.477701373748387 no 1589 0.464047650485121 2137 21230617 YGL099W LSG1 SGTC_1081 sertraline 6 µM 0.0891154002301224 0.478152040729036 no 1590 0.464495099238213 2250 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1177 0983-0204 23.6 µM 0.0883264116484346 0.478467809946734 no 1591 0.464808623764364 2245 766818 SGTC_2623 humulene 100 µM 0.0878237690222092 0.4786689847718 no 1592 0.465008372904218 2166 6187145 An anti-inflammatory. SGTC_2131 toluylene red 5.2905 µM 0.0866732717787241 0.479129473616568 no 1593 0.465465611238173 2174 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1027 k015-0025 8.67 µM 0.0863856670711464 0.479244592358136 no 1594 0.465579920178182 2265 3598955 SGTC_470 aa-861 153 µM 0.0854085553516147 0.479635711042152 no 1595 0.465968295915246 2136 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1719 st032227 49.2 µM 0.0852553578866648 0.479697034774662 no 1596 0.466029190752944 2191 3125804 SGTC_1524 corynanthine 62.1 µM 0.0849438505189111 0.479821730188595 no 1597 0.466153015035187 2154 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_943 3253-1379 105 µM 0.0840009590397509 0.480199178649861 no 1598 0.466527834630863 2225 668464 SGTC_556 4058-0063 51.5 µM 0.0836670617749955 0.480332845187111 no 1599 0.4666605730936 2173 6615692 SGTC_1827 berberine 7.24 µM 0.082654924348999 0.480738039868563 no 1600 0.467062963664394 2160 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2565 isoliquiritigenin 100 µM 0.0818520286347495 0.481059481812449 no 1601 0.467382190986747 2020 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1552 6-methylflavone 10.6 µM 0.0816888896088547 0.481124796571 no 1602 0.467447056819071 2268 689013 SGTC_2301 7769476 200 µM 0.0816442828371156 0.481142655540753 no 1603 0.467464793102122 2203 977820 SGTC_1723 st034307 2.5525 µM 0.0812002784987245 0.481320421191864 no 1604 0.467641339019609 2208 867466 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0804817248292264 0.4816081157867 no 1605 0.467927065277139 2256 66535 A nucleotide analog. SGTC_700 3453-2283 142 µM 0.0804235503914842 0.481631408095428 no 1606 0.467950198532249 2238 565664 SGTC_622 1348-1566 26.3 µM 0.0795415222645356 0.481984568632828 no 1607 0.468300953112375 2221 7340407 SGTC_2827 7993847 71.43 µM 0.0785343821027227 0.482387840800953 no 1608 0.46870149085322 2202 2985692 SGTC_1539 benzyladenosine 56 µM 0.0784507509768833 0.482421328619774 no 1609 0.468734752224248 2261 92208 A nucleotide analog. SGTC_1642 st009582 77.7 µM 0.0784088466291514 0.482438108127312 no 1610 0.468751418302914 2250 6739311 SGTC_1567 st069303 68.4 µM 0.0780986513486898 0.482562318735187 no 1611 0.468874789993617 2163 5581319 SGTC_1308 1187-1617 41.4 µM 0.0780679735782666 0.482574603039117 no 1612 0.468886991400542 2247 2882570 SGTC_2113 5491891 107.031 µM 0.0773986967895762 0.482842605735075 no 1613 0.469153188742844 2211 789979 SGTC_37 0566-0070 1.56 µM 0.0773381018025266 0.482866870549772 no 1614 0.469177290402408 2245 1626686 SGTC_787 4152-0075 138 µM 0.0753211223480715 0.483674590725887 no 1615 0.469979608006979 2131 9566539 SGTC_412 gemfibrozil 100 µM 0.0752908384421019 0.483686718746473 no 1616 0.469991655328884 2272 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2143 5623677 140.463 µM 0.0752747291689554 0.483693170152801 no 1617 0.469998063813259 2270 5375313 SGTC_2512 diallyl trisulfide 49.23 µM 0.0750362251290075 0.483788686225475 no 1618 0.470092944819513 2285 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_925 2064-1272 59.6 µM 0.074062668066944 0.48417858584565 no 1619 0.470480260106342 2093 6815817 SGTC_1101 ebselen 5.29 µM 0.0738178657972637 0.484276629039346 no 1620 0.470577655479396 2288 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1627 st003713 25.6 µM 0.0731583674787619 0.484540762518829 no 1621 0.470840047755124 2192 16195070 YER133W GLC7 SGTC_3208 9114115 49.47 µM 0.0719803984931577 0.485012563765785 no 1622 0.471308753558854 2119 650895 SGTC_1317 1273-0028 910 nM 0.0716879714418378 0.485129690200197 no 1623 0.471425114465643 2236 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_212 3807-4682 38.772 µM 0.0715976883732337 0.485165851731079 no 1624 0.471461039883388 2245 3125501 YBL034C STU1 SGTC_1947 st076332 61.6 µM 0.0713660156990398 0.485258645308223 no 1625 0.471553228082059 2277 24208416 SGTC_2142 5622915 118.518 µM 0.0711767898650022 0.485334437929682 no 1626 0.471628526780504 2199 5322196 SGTC_429 1112-0049 25.5 µM 0.0711353339842586 0.485351042762201 no 1627 0.471645023468302 2108 2836170 SGTC_232 clozapine 119 µM 0.0709481894762647 0.485426002363718 no 1628 0.471719495160884 2285 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_369 0957-0393 4.5 µM 0.0708188590601862 0.48547780518125 no 1629 0.471770961074844 2213 6997992 SGTC_17 0960-0276 49.807 µM 0.0690263249202146 0.486195822922345 no 1630 0.472484332606835 2298 6821114 SGTC_971 1315-0384 26.7 µM 0.0680398601334907 0.486590980643921 no 1631 0.472876951994639 2210 6769120 SGTC_1366 1683-0113 21.9 µM 0.0679878048571303 0.48661183329756 no 1632 0.472897671067843 2268 708623 SGTC_986 1493-0483 84 µM 0.0676922131253032 0.486730244119233 no 1633 0.47301532406001 2287 40079 SGTC_1131 3454-3128 32.3 µM 0.0661916508429855 0.487331370817732 no 1634 0.473612621930195 2202 710982 SGTC_695 3505-6186 243 µM 0.0660945379371648 0.487370275347892 no 1635 0.473651279719575 2245 1819379 SGTC_276 colchicine 750 µM 0.0648936983960625 0.487851355087006 no 1636 0.474129318985763 2204 2833 A microtubule depolymerizer. SGTC_2286 7945697 125 µM 0.0639852085873002 0.488215325605647 no 1637 0.474491002254678 2223 1245733 SGTC_1307 1187-1599 12.2 µM 0.0626824615189156 0.488737265437174 no 1638 0.475009681803328 2231 1538471 SGTC_417 st075190 100 µM 0.0614193236279637 0.489243354454478 no 1639 0.4755126316907 2303 222757 SGTC_1224 0823-0416 294 µM 0.0600964875807699 0.489773380696979 no 1640 0.476039393706707 2283 3598164 SGTC_2836 9010338 19.48 µM 0.0593320010162566 0.490079699015247 no 1641 0.47634383643896 2245 2994051 SGTC_133 0724-0033 378.92 µM 0.0577288772094004 0.490722065503196 no 1642 0.476982295680051 2310 280309 SGTC_1762 st045503 25.4615 µM 0.0560463918859829 0.491396257743305 no 1643 0.477652424917935 2254 4645554 SGTC_2777 climbazole 1.536 µM 0.0557648301297012 0.491509085401237 no 1644 0.477764576408448 2318 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2177 5811945 192 µM 0.0556354833498375 0.491560917577239 no 1645 0.47781609832215 2269 5343475 SGTC_108 0509-0257 621.132 µM 0.0551624369448659 0.491750479162434 no 1646 0.478004527161691 2292 536624 SGTC_398 bronopol 33.3 µM 0.0548781308972776 0.491864408641258 no 1647 0.478117777317244 2202 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_368 fentichlor 4.58 µM 0.0544254445965888 0.492045814218385 no 1648 0.478298103518858 2241 7329 A pesticide. SGTC_518 1021-0119 62.6 µM 0.0533394658952889 0.4924810065286 no 1649 0.478730717852443 2137 1097762 SGTC_98 0074-0023 107.663 µM 0.0532790231585537 0.492505228463095 no 1650 0.478754796776693 2175 3563821 SGTC_1637 st007924 17.4 µM 0.0513622542789229 0.493273371840972 no 1651 0.479518430887365 2314 683336 SGTC_2101 5377231 179.231 µM 0.0510180159759551 0.493411327751085 no 1652 0.479655582284689 2256 2844213 SGTC_1195 1502-0147 41.1 µM 0.0497308480647005 0.49392717615236 no 1653 0.480168436832532 2309 817940 SGTC_402 epigallocatechin gallate 10 µM 0.0496746751532218 0.493949688376336 no 1654 0.480190818918895 2205 65064 An antioxidant. SGTC_602 3130-1533 38.1 µM 0.0486739519222753 0.494350747935882 no 1655 0.480589567309159 2302 720941 SGTC_3292 9120825 59.784 µM 0.0486340367731245 0.494366744839763 no 1656 0.480605472313386 2324 24824900 SGTC_1303 1160-0052 261 µM 0.047161041148129 0.49495708745955 no 1657 0.48119243880602 2323 3562476 SGTC_1575 cyproterone acetate 48 µM 0.0458079323613802 0.495499391967124 no 1658 0.481731668169689 2274 9880 An androgen receptor antagonist and liver toxin. SGTC_2581 avocatin a 64 µM 0.0453173985005861 0.49569599225313 no 1659 0.481927159843319 2287 6710728 A skin care supplement. SGTC_2970 9090938 41.86 µM 0.0452537005332922 0.495721521737847 no 1660 0.481952545611968 2318 17217104 SGTC_2968 9090663 33.37 µM 0.0452061289412414 0.49574058795004 no 1661 0.481971504528903 2207 25236811 SGTC_2553 4-methylesculetin 85.09 µM 0.0448525138768212 0.495882313587762 no 1662 0.482112433579229 2323 5319502 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0435161536071362 0.496417918931539 no 1663 0.482645044003462 2323 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_24 0417-1663 219 µM 0.0430676855343732 0.496597663794922 no 1664 0.482823789297746 2274 4329390 SGTC_614 0462-0418 107 µM 0.0406978937083081 0.497547480936786 no 1665 0.483768370391655 2304 5188303 SGTC_161 4065-0411 162.148 µM 0.0392808164786885 0.498115455214875 no 1666 0.484333250521688 2302 1906281 YLR208W SEC13 SGTC_2687 chenodiol 100 µM 0.0390817317048071 0.498195250090884 no 1667 0.484412612914386 2292 5702181 A cholesterol synthesis inhibitor. SGTC_3165 9101544 49.47 µM 0.0389875903661438 0.498232982767995 no 1668 0.484450141272736 2321 5002184 SGTC_1954 st077032 68.9 µM 0.0381125288039091 0.498583715855592 no 1669 0.48479898101381 2146 698907 SGTC_200 k038-0079 37.545 µM 0.0379983212861728 0.498629491413327 no 1670 0.484844510241348 2280 3436683 SGTC_451 chloral hydrate 100 µM 0.0375242289039508 0.498819512743832 no 1671 0.485033510938257 2297 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3330 9141424 71.43 µM 0.0373361706106713 0.498894888608859 no 1672 0.485108482805579 2330 27261020 SGTC_1861 st057647 17.4 µM 0.0369794460500384 0.499037867904445 no 1673 0.48525069710279 2339 688668 SGTC_2907 7721985 69.9 µM 0.0368729685774429 0.499080545321556 no 1674 0.485293146517791 2320 3267881 SGTC_3020 9089140 49.47 µM 0.0365032875283333 0.499228717890938 no 1675 0.485440528694734 2311 17217859 SGTC_2889 9059656 51.95 µM 0.0354374119483446 0.499655934047528 no 1676 0.485865476507416 2308 3949838 SGTC_2008 4012253 172 µM 0.0348657457998365 0.499885065126166 no 1677 0.486093397444349 2327 603940 SGTC_1897 st060201 15 µM 0.0347079111405505 0.499948327279221 no 1678 0.486156326275837 2279 611878 SGTC_3211 9128781 49.47 µM 0.0344500714774652 0.499948327279221 no 1679 0.48625912794003 2197 17194361 SGTC_3114 9122766 49.47 µM 0.0333795441264199 0.499519246311561 no 1680 0.486685960996998 2239 17176985 SGTC_1653 st012112 65 µM 0.031959912445983 0.498950240832866 no 1681 0.48725200989365 2337 720429 SGTC_1963 st076565 50.3 µM 0.0319411300998603 0.498942712654046 no 1682 0.487259499142021 2346 4914280 SGTC_827 3253-0474 693 µM 0.0314708832906642 0.498754232492419 no 1683 0.487447006203324 2347 5402065 SGTC_558 k064-0027 21.3 µM 0.0304986336522058 0.498364544931685 no 1684 0.487834691531605 2319 5088526 SGTC_70 0141-0289 43.283 µM 0.0304063734523889 0.498327566178854 no 1685 0.48787148096371 2236 352408 SGTC_2938 9059746 27.26 µM 0.0301390099426727 0.498220404460487 no 1686 0.487978094708132 2317 6471769 SGTC_2917 7979103 53.79 µM 0.0295852873333216 0.497998467836245 no 1687 0.488198899592696 2336 2980565 SGTC_445 e6 berbamine 66 µM 0.0288823729373064 0.497716734805032 no 1688 0.488479202057806 2327 6610268 A calcium/calmodulin antagonist. SGTC_1948 st076329 66.6 µM 0.028237821825962 0.497458395186004 no 1689 0.488736235893602 2364 24208413 SGTC_1090 efavirenz 20.7 µM 0.0280689245456891 0.497390700401958 no 1690 0.488803589461741 2284 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.02759542640246 0.49720092063883 no 1691 0.488992414739976 2226 61125 An anti-inflammatory. SGTC_731 3966-0296 387 µM 0.0275731344683724 0.497191985966545 no 1692 0.489001304552256 2356 660956 SGTC_1071 trifluoperazine 6.31 µM 0.0273520865792102 0.497103389403959 no 1693 0.489089456652853 2335 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_332 4112-0506 40.9 µM 0.0247762960676377 0.496071017616452 no 1694 0.490116699125715 2351 2790355 SGTC_22 0964-0034 14.468 µM 0.0227466699158401 0.495257565624074 no 1695 0.490926174121858 2350 138402 SGTC_1651 st011928 86.1 µM 0.0219576319643513 0.494941332968618 no 1696 0.49124087608808 2352 720198 SGTC_2513 baicalein 25.65 µM 0.0218893332836515 0.494913960194706 no 1697 0.491268116772246 2348 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_660 4031-1742 102 µM 0.0218504157205687 0.494898362808144 no 1698 0.49128363892111 2362 6738706 SGTC_1476 4112-3294 3.34 µM 0.0216948250668394 0.494836005241591 no 1699 0.49134569590055 2357 704369 SGTC_1450 4112-4260 37.6 µM 0.0212900623313073 0.494673785172119 no 1700 0.491507135577354 2364 1633175 SGTC_3091 9116372 49.47 µM 0.0201388263765758 0.494212399835156 no 1701 0.491966313724531 2308 17169793 SGTC_2642 cholecalciferol 100 µM 0.0200818414640383 0.494189561964865 no 1702 0.491989042818907 2370 9821465 A vitamin D precursor, similar to steriods. SGTC_2522 biochanin a 4.94 µM 0.0193511067626896 0.49389670678777 no 1703 0.492280507123219 2361 5280373 A possible chelator. SGTC_815 1582-0027 36.9 µM 0.0191259588807674 0.493806475348535 no 1704 0.492370311511682 2346 3128206 SGTC_3068 9116768 49.47 µM 0.0189341037569312 0.493729586738524 no 1705 0.49244683677441 2346 41904888 SGTC_1011 4112-3381 17.4 µM 0.0188352334822925 0.493689963191234 no 1706 0.492486273274462 2305 2877139 SGTC_883 0850-0245 24.6 µM 0.0171071280037494 0.492997412866115 no 1707 0.493175576210313 2343 6823229 YPR165W RHO1 SGTC_2799 7812892 81.82 µM 0.0169732857377587 0.492943775498268 no 1708 0.493228963797478 2365 20205235 SGTC_1446 4239-0190 62 µM 0.0166225483352591 0.492803217882923 no 1709 0.493368868036154 2366 1340085 SGTC_514 4466-0038 2.65 nM 0.0162687086318365 0.492661417929501 no 1710 0.493510010565694 2306 5722064 SGTC_2639 lactacystin 53 µM 0.0157043588505336 0.492435258766734 no 1711 0.493735124783429 2369 3870 A proteasome inhibitor. SGTC_496 calpeptin 138 µM 0.0155476725191757 0.49237246826154 no 1712 0.49379762595471 2301 73364 A calpain inhibitor. SGTC_3149 9097855 49.47 µM 0.0151168055487648 0.492199803542835 no 1713 0.493969496802429 2369 25236625 YMR079W SEC14 SGTC_1051 3253-3903 78 µM 0.0150302775815106 0.492165128683374 no 1714 0.494004012545581 2376 5509239 SGTC_584 0986-0246 15.4 µM 0.0146847708504867 0.492026672338811 no 1715 0.494141834575392 2374 53315 YDR232W HEM1 SGTC_2701 st077767 14.721 µM 0.0144153100454873 0.49191869085932 no 1716 0.494249322504695 2369 5721188 SGTC_1458 k015-0034 6.33 µM 0.0142903042159318 0.491868597264583 no 1717 0.494299187478936 2355 3598957 SGTC_110 0850-0284 111.64 µM 0.0121986605422049 0.491030432389685 no 1718 0.495133559239416 2389 3906265 SGTC_2382 9035899 200 µM 0.0120336115743188 0.490964295492557 no 1719 0.495199399418097 2382 6462679 SGTC_1763 st044482 94.5 µM 0.0115619700524381 0.490775305035923 no 1720 0.495387544066442 2380 88505 SGTC_1264 0783-0040 158 µM 0.0102579646238297 0.490252790742093 no 1721 0.49590773596947 2378 2855798 SGTC_1094 duloxetine 25.4 µM 0.010211553494846 0.490234194129911 no 1722 0.495926250361382 2390 60834 A selective serotonin reuptake inhibitor. SGTC_2787 5284540 71.43 µM 0.0101553742116395 0.490211683515603 no 1723 0.495948661490653 2378 736958 SGTC_2980 9014342 25.29 µM 0.00932444037315534 0.489878738284095 no 1724 0.496280140398127 2347 2996599 SGTC_686 1319-0111 510 µM 0.00760400332684564 0.489189402457152 no 1725 0.496966470806184 2385 4562600 SGTC_359 0081-0058 15.9 µM 0.0047485460959312 0.488045364879117 no 1726 0.498105611311231 2397 3494159 SGTC_2346 9031566 143.75 µM 0.00417871353966485 0.487817073209636 no 1727 0.498332939342947 2395 4771086 SGTC_134 0269-0018 6.916 µM 0.0039730170791646 0.487734666138768 no 1728 0.498414999676201 2394 4378915 SGTC_2709 st078560 56 µM 0.00379788443565326 0.487664504098741 no 1729 0.498484866964901 2397 17250903 SGTC_2651 TUB2.036 5 µM 0.00303328405134935 0.487358192645172 no 1730 0.498789896599105 2391 15992207 YFL037W TUB2 SGTC_2352 9027995 87.8 µM 0.00154660909659391 0.486762627786427 no 1731 0.499382992486096 2381 2997347 SGTC_1455 4262-0120 131 µM 0.00129774693528939 0.486662935972365 no 1732 0.499482274023573 2395 1529587 SGTC_1346 1488-2224 62.4 µM 0.000419969019457903 0.486311313186899 no 1733 0.499832456606605 2396 3722427 SGTC_3270 9137563 49.47 µM -0.000684120287399244 0.485869049082485 no 1734 0.499727075513765 2412 17015724 SGTC_714 4296-0578 26.1 µM -0.00154164624065627 0.485525562612509 no 1735 0.4993849723768 2409 1589775 SGTC_62 0180-0423 3.232 µM -0.00177948809402325 0.485430295715559 no 1736 0.499290087336489 2414 30102 YGL099W LSG1 SGTC_473 2-arachidonoylglycerol 10 µM -0.00428121127556468 0.484428288828836 no 1737 0.498292049028288 2395 5282280 An endocannabinoid. SGTC_256 clotrimazole 625 nM -0.00490596574071361 0.484178073091902 no 1738 0.498042810690933 2409 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2556 citropten 84.59 µM -0.0058337989156724 0.483806485094821 no 1739 0.497672664158304 2412 2775 A potential DNA crosslinker. SGTC_190 3970-0790 3.722 µM -0.00590431789086357 0.48377824351471 no 1740 0.497644531642064 2420 2832352 SGTC_1525 8-methoxypsoralen 92.5 µM -0.00597164816624419 0.483751279027416 no 1741 0.497617671222017 2420 4114 Related to psoralen; DNA damaging agent. SGTC_1572 epiandrosterone 68.9 µM -0.0105115867005721 0.481933298220285 no 1742 0.495806560855775 2421 441302 A steroid. SGTC_351 caspofungin 25 nM -0.0106255782231961 0.481887655934749 no 1743 0.495761087357468 2426 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3024 9090631 49.47 µM -0.0108297089915354 0.481805922425673 no 1744 0.495679655649199 2428 25236383 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0114823924591743 0.481544594554303 no 1745 0.495419288825662 2425 17037758 SGTC_517 1365-0151 113 µM -0.0117769356148249 0.481426665038448 no 1746 0.495301791053896 2462 768657 SGTC_231 b-estradiol 524 µM -0.0130577706503901 0.480913861918931 no 1747 0.494790851231505 2420 450 A steroid. SGTC_1058 3448-5425 97.3 µM -0.0132728104332264 0.480827770320761 no 1748 0.494705070204644 2430 7279705 SGTC_3135 9127742 49.47 µM -0.0136884211079375 0.480661382311015 no 1749 0.494539280600417 2456 3643468 SGTC_3237 9133362 49.47 µM -0.0138578874956979 0.480593538110924 no 1750 0.494471679705555 2427 43845137 SGTC_606 k015-0008 38.6 µM -0.0144946275736879 0.480338630528914 no 1751 0.494217682694808 2439 1970475 SGTC_1885 st057546 99.9 µM -0.0152773706199027 0.480025284278937 no 1752 0.493905448003375 2457 702008 SGTC_1499 4480-0877 67.3 µM -0.0154091135330014 0.479972546407662 no 1753 0.493852896371322 2435 2861909 SGTC_2854 9024559 71.43 µM -0.015669678577903 0.479868240913352 no 1754 0.493748958508253 2445 3163529 SGTC_3337 9144342 33.5465 µM -0.0173619982160426 0.479190830743338 no 1755 0.49307391280656 2455 17682949 SGTC_3151 9099821 49.47 µM -0.0180632727502382 0.478910138566127 no 1756 0.492794188633848 2464 17174189 SGTC_1650 st011916 45.8 µM -0.0199718428918383 0.47814626756685 no 1757 0.492032917100811 2448 242528 SGTC_1520 flindersine 88 µM -0.0199878229802909 0.478139872157758 no 1758 0.492026543240212 2464 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2900 5328528 85.29 µM -0.0201445755520974 0.478077138334167 no 1759 0.491964020600532 2430 795359 SGTC_1212 0520-0165 585 µM -0.0203057271246261 0.478012644556239 no 1760 0.491899743572587 2463 5403258 SGTC_2695 st077686 51.995 µM -0.0212212681118449 0.477646250812131 no 1761 0.491534574300986 2460 2876092 SGTC_920 mycophenolic acid 780.421 nM -0.0231573629227317 0.476871500448161 no 1762 0.490762374468401 2460 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1430 4049-0248 69.1 µM -0.0250225209996816 0.476125218859134 no 1763 0.490018500035564 2453 22774488 SGTC_2816 7982706 58.44 µM -0.0252510449094352 0.476033788247221 no 1764 0.48992736098409 2485 2981853 SGTC_2752 diclazuril 33.15 µM -0.0255477975682487 0.475915061735424 no 1765 0.489809011983541 2465 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_336 4111-0029 111 µM -0.026166799396509 0.475667414815455 no 1766 0.489562148526777 2487 3131175 SGTC_3056 9094900 49.47 µM -0.0262661205904886 0.475627679799303 no 1767 0.48952253871748 2473 25236784 SGTC_868 0527-0199 213 µM -0.0265475021851066 0.475515109954759 no 1768 0.489410322834823 2494 2849450 SGTC_1843 st055809 45.5 µM -0.0265625048053465 0.475509108044041 no 1769 0.4894043397652 2531 16413835 SGTC_3300 9124615 50.48 µM -0.0270030305912799 0.475332874883305 no 1770 0.48922865842588 2486 24824903 SGTC_2789 5281112 71.43 µM -0.0271161412995804 0.475287625511131 no 1771 0.489183550299583 2470 765948 SGTC_1698 5-fluorocytosine 1.055 µM -0.0284589741809648 0.474750456458958 no 1772 0.488648044312855 2460 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2625 euphol 100 µM -0.0306820489686938 0.473861268465043 no 1773 0.487761553635182 2479 6708538 A triterpene alcohol. SGTC_1714 st033236 13.627 µM -0.0319637146487916 0.473348685251685 no 1774 0.487250493808772 2483 2916566 SGTC_2419 paclitaxel 166.5 µM -0.0321373270753463 0.473279254906681 no 1775 0.487181268036235 2446 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1367 1812-0510 76.9 µM -0.0324369716232364 0.47315942424122 no 1776 0.487061789449494 2480 1142582 YDR527W RBA50 SGTC_1578 josamycin 24.2 µM -0.0328763032036565 0.47298373581546 no 1777 0.486886614941215 2472 5282165 A P450 substrate. SGTC_2413 inermin 26.06 µM -0.0344822627966413 0.47234155854775 no 1778 0.486246293087381 2487 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_319 1348-1596 45.5 µM -0.0345035470479001 0.472333048063995 no 1779 0.486237806949385 2508 5380505 SGTC_1647 st011722 22.4 µM -0.0362158137522798 0.471648441879251 no 1780 0.485555138355115 2497 2854783 SGTC_2253 7938677 135.83 µM -0.0369244215921876 0.471365147491392 no 1781 0.485272633703751 2500 2301972 SGTC_1871 st057448 67.3 µM -0.0372321132647019 0.471242139914866 no 1782 0.485149966836805 2505 691747 SGTC_2166 5933061 31.504 µM -0.0373446719447938 0.471197142402745 no 1783 0.485105093627559 2582 2877375 SGTC_1060 3448-7350 82 µM -0.0373618216089907 0.471190286524637 no 1784 0.485098256672762 2480 570178 SGTC_1198 1612-1005 86.7 µM -0.0386904893593194 0.47065915447266 no 1785 0.484568578062544 2524 6998509 SGTC_1033 k072-0102 21.3 µM -0.0405411423639429 0.469919447124756 no 1786 0.483830853562195 2470 5965931 SGTC_2815 7968870 71.43 µM -0.0412984772589124 0.469616769602373 no 1787 0.483528973503843 2491 2977326 YHR190W ERG9 SGTC_2137 5261020 140 µM -0.0417127777634382 0.469451197101736 no 1788 0.483363833822733 2478 763655 SGTC_3127 9126946 49.47 µM -0.0423957920592896 0.469178246429344 no 1789 0.483091591392686 2533 27243249 SGTC_511 blebbistatin 171 µM -0.0428223816962705 0.469007777208831 no 1790 0.482921561169329 2571 3476986 A myosin inhibitor. SGTC_528 3492-0019 172 µM -0.043599383271982 0.468697294711094 no 1791 0.482611871654716 2483 2869262 SGTC_1814 st052110 31.539 µM -0.0441642119164298 0.468471606452967 no 1792 0.482386754478814 2505 674163 SGTC_2200 6600604 21.907 µM -0.0459351789196305 0.467764048200702 no 1793 0.481680957518344 2490 2904777 SGTC_2940 9060638 45.86 µM -0.0464220109451255 0.46756956090512 no 1794 0.481486946612658 2522 4027022 SGTC_2283 7944793 200 µM -0.047260412768265 0.467234641162594 no 1795 0.481152839420491 2512 2970533 SGTC_430 0958-0115 16.4 µM -0.0473201385613946 0.467210783142474 no 1796 0.481129038904652 2538 6833180 SGTC_1635 st007035 42.4 µM -0.0477972307573238 0.467020208490871 no 1797 0.480938921785627 2484 3716403 SGTC_3282 9108498 15.4605 µM -0.0481630423604811 0.466874090030977 no 1798 0.48079315195577 2548 16459645 SGTC_2350 9023895 38.85 µM -0.0487049613308989 0.466657636094106 no 1799 0.480577210999977 2542 2997209 SGTC_2105 5350118 200 µM -0.0487848220318201 0.466625738867553 no 1800 0.480545389017852 2513 2133313 SGTC_778 3456-2434 196 µM -0.0494000060990781 0.46638003490686 no 1801 0.480300261651558 2611 5539063 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0503633873043935 0.465995287102182 no 1802 0.479916406020278 2534 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2576 guaiol 23.12 µM -0.0511329021867918 0.465687986957031 no 1803 0.479609809061093 2569 227829 SGTC_2310 7668677 200 µM -0.0514566115319478 0.465558722098208 no 1804 0.479480837500864 2539 2197143 SGTC_1345 1488-0192 31.4 µM -0.0516190742812232 0.465493848217964 no 1805 0.479416110260971 2504 658348 SGTC_1722 st034304 3.6505 µM -0.0516878951191547 0.465466367272873 no 1806 0.479388691321358 2507 4036148 YLR033W RSC58 SGTC_1710 st031758 61.5 µM -0.0525933831693988 0.465104810959692 no 1807 0.479027944570863 2614 5394341 SGTC_977 1348-1378 135 µM -0.0535224810314424 0.464733857325866 no 1808 0.478657809522955 2491 X977 SGTC_3250 9135583 49.47 µM -0.0535790192097309 0.464711284755823 no 1809 0.478635286370974 2605 7699353 SGTC_3233 9132340 49.47 µM -0.054335359080648 0.464409330994016 no 1810 0.47833398933948 2506 17682950 SGTC_1228 0124-0032 52.5 µM -0.0545678660957852 0.464316511269226 no 1811 0.478241369870039 2533 X1228 SGTC_497 capsazepine 133 µM -0.0546814601236662 0.464271163810411 no 1812 0.478196119969469 2508 2733484 A calcium channel blocker. SGTC_3308 9128332 17.569 µM -0.0553807352455033 0.463992018976409 no 1813 0.477917571663765 2528 17332805 YDL196W YDL196W SGTC_1865 st057639 52.2 µM -0.0570193734057235 0.463337957873422 no 1814 0.477264881250345 2504 688818 SGTC_873 0591-4978 488 µM -0.0575501164613504 0.463126133369292 no 1815 0.477053492533078 2518 3305145 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.057667818463853 0.463079158816444 no 1816 0.477006614082337 2489 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1648 st011736 69.8 µM -0.0582241345349127 0.462857141545788 no 1817 0.476785048375201 2556 2855514 SGTC_296 1222-0039 74.9 µM -0.0590306239447173 0.462535304468212 no 1818 0.476463858126897 2537 5984176 SGTC_1835 st008666 49.2 µM -0.0591344031885855 0.462493892175144 no 1819 0.476422528397437 2520 690455 SGTC_2315 7733312 200 µM -0.0594841376014666 0.462354336397616 no 1820 0.476283249732071 2539 726316 SGTC_2595 hexamethylquercetagetin 100 µM -0.0598630575478775 0.462203139842737 no 1821 0.476132351454506 2568 386331 SGTC_632 0781-2353 4.65 µM -0.0602565004285883 0.462046154129525 no 1822 0.475975673293395 2576 6811515 YHR007C ERG11 SGTC_1120 ficusin 1.78878 µM -0.0602813071417847 0.462036256322508 no 1823 0.475965794803985 2642 6199 A DNA cross-linker. SGTC_255 tunicamycin 200.472 nM -0.0608812707240701 0.461796879758254 no 1824 0.475726882785002 2517 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2295 7971645 200 µM -0.0614549257608745 0.461568012853273 no 1825 0.475498455274458 2578 2978226 YKL099C UTP11 SGTC_322 k048-0136 19.3 µM -0.0615420793438983 0.461533242944953 no 1826 0.475463751712978 2596 6823282 SGTC_766 1391-0721 126 µM -0.0620544127147827 0.461328853579725 no 1827 0.475259750187335 2528 1020919 YIL115C NUP159 SGTC_2058 5236698 133 µM -0.0623190209901139 0.461223295220725 no 1828 0.475154390678455 2549 766665 SGTC_1423 4048-0112 5.59 µM -0.0625363250655891 0.461136609643428 no 1829 0.475067867658965 2541 X1423 SGTC_930 2810-3379 265 µM -0.0628460167201124 0.461013072585254 no 1830 0.474944561111458 2532 1015764 SGTC_1811 st050069 61.5 µM -0.0643579091653746 0.46041002776531 no 1831 0.474342622065743 2521 3877702 SGTC_3003 9075612 71.4286 µM -0.0648919288984859 0.460197046315861 no 1832 0.474130023428368 2587 6501993 SGTC_2808 7946468 45.46 µM -0.065313460071741 0.460028936394774 no 1833 0.473962212820122 2573 2970879 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0655616568455123 0.459929956924873 no 1834 0.473863408403995 2502 756377 SGTC_1437 4092-1038 11.6 µM -0.0664989760473408 0.459556181774889 no 1835 0.4734902864514 2528 3977136 SGTC_2928 9011484 9.79 µM -0.0672646841578193 0.459250866559323 no 1836 0.47318549557412 2597 2994751 SGTC_1738 st035555 74 µM -0.0673235868077666 0.459227380958816 no 1837 0.47316204996351 2595 5331140 SGTC_747 3448-8087 38.7 µM -0.0674019711740648 0.459196127850244 no 1838 0.47313084999478 2562 5168703 SGTC_1315 1237-0019 3.69 µM -0.0674635919163524 0.45917155884544 no 1839 0.473106322703781 2527 825140 SGTC_955 1216-0110 33 µM -0.0693930527085931 0.45840233667494 no 1840 0.47233837936303 2519 3619719 SGTC_2277 7947813 106.88 µM -0.0697906987654317 0.458243825552395 no 1841 0.472180125218436 2754 1246798 SGTC_2427 5545055 42.75 µM -0.0703809264882673 0.458008559073543 no 1842 0.471945236027472 2542 5372858 SGTC_2118 5526350 200 µM -0.0715755686166776 0.457532416370797 no 1843 0.471469841807222 2650 743594 SGTC_1872 amphotericin b 148 nM -0.0717150337299891 0.457476834398713 no 1844 0.471414345891492 2575 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0723271318695454 0.457232900649347 no 1845 0.471170786563047 2593 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1391 3442-0225 151 µM -0.0723368359530513 0.457229033501167 no 1846 0.471166925307948 2552 5227075 SGTC_2423 st077119 87.2 µM -0.0725227012605791 0.457154965600153 no 1847 0.47109297002042 2495 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_325 2810-4341 181 µM -0.0726017852023928 0.457123450855469 no 1848 0.47106150304269 2547 774970 SGTC_1596 piperlongumine 63 µM -0.0733251275193291 0.456835213364188 no 1849 0.470773698324115 2547 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2055 5235184 200 µM -0.0736542759831383 0.456704061772337 no 1850 0.470642741196316 2612 2836034 SGTC_2708 st078559 56 µM -0.0759385819646627 0.455793994203203 no 1851 0.469733980747406 2536 17250902 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0775028676832091 0.45517091620693 no 1852 0.469111755028188 2545 688667 SGTC_2870 9038528 12.99 µM -0.078410567698155 0.454809416403297 no 1853 0.468750733803139 2697 6463316 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0792735673640968 0.454465753619781 no 1854 0.468407515154335 2551 6312947 SGTC_1859 st055998 20 µM -0.0798754594082959 0.45422608898711 no 1855 0.46816815400395 2547 676301 SGTC_2780 5215298 71.43 µM -0.082168890562333 0.453313031624393 no 1856 0.467256205750906 2576 2834131 SGTC_1887 st057648 70.8 µM -0.082818374198383 0.453054504799545 no 1857 0.466997979409977 2659 688672 SGTC_2097 5376186 200 µM -0.083958596582659 0.452600687711607 no 1858 0.466544675315935 2576 742755 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0840265842387822 0.452573630062914 no 1859 0.466517647670422 2821 5282309 SGTC_2962 9082311 13.18 µM -0.0840577983556572 0.452561207578569 no 1860 0.466505238938919 2573 16459453 SGTC_3180 9109287 49.47 µM -0.085531995286584 0.451974564968646 no 1861 0.465919230051019 2645 18891271 SGTC_2351 9026858 72.31 µM -0.0881220878167036 0.450944117040362 no 1862 0.46488982056551 2557 1409300 SGTC_1223 0764-0573 147 µM -0.0886940112951309 0.450716626092771 no 1863 0.464662546036626 2581 1609797 SGTC_220 paclitaxel 373.376 µM -0.0904341179900036 0.450024573014747 no 1864 0.463971122761955 2662 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1002 4049-0206 172 µM -0.0914253960433475 0.449630402329064 no 1865 0.46357729156264 2599 4662749 SGTC_828 2074-0507 139 µM -0.0915580370093928 0.449577662886271 no 1866 0.463524596483642 2657 X828 SGTC_1062 mesoridazine 14.2 µM -0.092051641551499 0.449381408361965 no 1867 0.463328504850302 2554 4078 A neuroleptic. SGTC_2531 methyl deoxycholate 70.07 µM -0.0929787595997755 0.449012824694244 no 1868 0.462960217748479 2589 16667744 Haematoxylin. SGTC_344 k064-0035 6.43 µM -0.0933466047440767 0.448866596901041 no 1869 0.462814104226904 2584 5088750 SGTC_2324 6149169 200 µM -0.0965651069963584 0.447587458869994 no 1870 0.461535883768051 2624 2888231 SGTC_2653 dihydrofissinolide 100 µM -0.0974914693350657 0.447219392591041 no 1871 0.461168054222423 2605 6857746 SGTC_2199 6590217 200 µM -0.0999019662435861 0.446261857359534 no 1872 0.460211077663005 2616 703109 SGTC_56 0957-0365 83.25 µM -0.100964662980386 0.445839815534017 no 1873 0.459789255823941 2563 6752360 SGTC_576 1073-0113 22.7 µM -0.101375745187699 0.445676573833525 no 1874 0.459626094901666 2601 5439563 SGTC_3288 9119690 36.221 µM -0.10311656963009 0.444985390795187 no 1875 0.458935227231259 2626 17595618 YKL019W RAM2 SGTC_1335 1486-0900 202 µM -0.103789827702362 0.444718122777364 no 1876 0.458668069593551 2582 X1335 SGTC_122 0236-0016 402.397 µM -0.103810622710253 0.444709868035515 no 1877 0.458659818158127 2603 6808838 SGTC_733 4069-0007 56.1 µM -0.105542753449765 0.444022369645659 no 1878 0.457972573530631 2598 5717425 YNL287W SEC21 SGTC_2982 9019404 25.97 µM -0.108070018502381 0.443019577917099 no 1879 0.456970075302427 2626 22333232 SGTC_1125 tnp00248 1.32998 µM -0.108211441788502 0.442963473391246 no 1880 0.456913984509521 2731 24207736 SGTC_669 0108-0021 26.2 µM -0.108291226949071 0.442931822046 no 1881 0.456882340785992 2558 17201 SGTC_71 0417-1750 47.813 µM -0.109811720637019 0.442328701129511 no 1882 0.45627934776946 2629 6811472 SGTC_3309 9129340 25.759 µM -0.109948547233863 0.442274433855231 no 1883 0.456225090387738 2665 17158987 SGTC_3124 9127567 49.47 µM -0.110554247984374 0.44203421779085 no 1884 0.455984914908558 2654 17592030 SGTC_1838 st055369 84.5 µM -0.11108441931985 0.441823973577552 no 1885 0.455774701925529 2591 676036 SGTC_286 k060-0067 22.9 µM -0.112266797263789 0.441355150081785 no 1886 0.455305933640348 2624 5985051 SGTC_1492 4158-0558 28.5 µM -0.112520617893795 0.44125451860712 no 1887 0.455205311418352 2713 3967268 SGTC_1526 st051518 75 µM -0.112859098275557 0.441120328246366 no 1888 0.455071131966855 2678 673993 SGTC_2442 5158906 48.48 µM -0.114699758737853 0.44039071813933 no 1889 0.454341552583151 2723 1893835 SGTC_2434 5670830 169.91 µM -0.115023872826699 0.440262265073473 no 1890 0.454213099924153 2703 1549830 SGTC_1906 st060206 94.7 µM -0.115104430607551 0.440230339346437 no 1891 0.454181174065786 2619 5133468 SGTC_1686 st019653 115.5 µM -0.11562249183798 0.440025036611096 no 1892 0.453975868274524 2601 97252 SGTC_1878 temozolomide 1 mM -0.115714124443071 0.439988725158479 no 1893 0.453939555883018 2595 5394 DNA alkylating agent. SGTC_3272 9137413 49.47 µM -0.116591800379614 0.439640952212797 no 1894 0.453591767878224 2612 17614870 SGTC_829 1635-0120 117 µM -0.116887457573703 0.439523810593047 no 1895 0.453474618711994 2746 285054 SGTC_1771 st048882 4.1505 µM -0.11798616650378 0.439088540273311 no 1896 0.453039309424442 2618 4580403 SGTC_173 1273-0061 2.693 µM -0.119305123251037 0.438566112727963 no 1897 0.452516812362412 2717 2847414 YPL266W DIM1 SGTC_3323 9138564 53.9225 µM -0.119404285989932 0.438526839525178 no 1898 0.452477532930479 2657 43912313 YNL103W MET4 SGTC_1421 4029-0249 71.4 µM -0.121628029008444 0.437646290289305 no 1899 0.451596807173777 2722 2894095 SGTC_627 1391-0720 175 µM -0.121885158532266 0.437544492955185 no 1900 0.451494984880437 2695 997839 SGTC_2560 caryophyllene 100 µM -0.122351037700585 0.43736006237005 no 1901 0.451310506671457 2610 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_450 aminopyrene 156 nM -0.122398356888856 0.437341330579132 no 1902 0.451291769870261 2638 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_310 1273-0058 1.06 µM -0.12295504532748 0.437120970249809 no 1903 0.451071348200001 2655 2734232 SGTC_994 3910-0338 138 µM -0.123269255943349 0.436996601288199 no 1904 0.450946942664843 2759 3479481 SGTC_2221 6807166 181.081 µM -0.124063750517462 0.436682157013412 no 1905 0.450632399632201 2637 674925 SGTC_2800 7887935 81.82 µM -0.124797834359283 0.436391657589863 no 1906 0.450341800960093 2745 2961002 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.12572214046763 0.436025930208042 no 1907 0.449975937683495 2736 5377381 SGTC_1157 4092-0394 27.6 µM -0.126564004438297 0.435692870933766 no 1908 0.449642744035479 2804 3659885 SGTC_2102 5377816 72.7585 µM -0.126594220418959 0.435680917696205 no 1909 0.449630785787158 2756 1379702 SGTC_593 1203-0218 61.7 µM -0.128679029601273 0.434856323764091 no 1910 0.448805814695428 2735 3666956 SGTC_121 0557-0495 61.343 µM -0.129264681696114 0.434624734589603 no 1911 0.448574108423227 2637 3104427 SGTC_2665 lovastatin 100 µM -0.129951422662632 0.434353199597138 no 1912 0.448302429892554 2650 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2897 9048598 12.99 µM -0.130342099407859 0.434198741180594 no 1913 0.448147886819058 2655 6467404 SGTC_945 3381-0768 11.3 µM -0.130815881390328 0.434011439659694 no 1914 0.447960479713705 2664 1126236 YIL048W NEO1 SGTC_295 k015-0027 31 µM -0.130955818308394 0.43395612084909 no 1915 0.447905129105415 2725 3887424 SGTC_2291 7917025 104.35 µM -0.131673022120582 0.433672621554556 no 1916 0.447621462460181 2662 2964612 SGTC_1135 dihydrocapsaicin 536.708 nM -0.131833375132453 0.433609241213531 no 1917 0.447558043699838 2620 107982 A Capsaicinoid. SGTC_2959 9079155 11 µM -0.133029308620937 0.433136596392097 no 1918 0.447085100782325 2793 16189457 SGTC_1245 0418-0076 17.2 µM -0.133436948308953 0.432975514946947 no 1919 0.446923913071216 2814 6790114 SGTC_644 1498-1197 63.3 µM -0.135861470978539 0.432017680192386 no 1920 0.44596539734622 2738 6741615 SGTC_855 0428-0020 25 µM -0.136958113108223 0.431584570341515 no 1921 0.44553195196967 2667 6812414 SGTC_2751 anetholtrithion 17.25 µM -0.14083423160939 0.430054391442643 no 1922 0.444000449827346 2772 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_80 0159-0065 512.242 µM -0.140979472923871 0.429997074659746 no 1923 0.443943079301047 2627 1548079 SGTC_1021 4476-0760 85.3 µM -0.14126426801127 0.429884689859842 no 1924 0.443830588246605 2670 746768 SGTC_609 0986-0026 86.3 µM -0.142362628860069 0.42945131198577 no 1925 0.443396789764018 2664 2848610 SGTC_2988 9073640 71.4286 µM -0.142679955566772 0.429326120875765 no 1926 0.443271473936991 2817 9102229 SGTC_2275 7947463 200 µM -0.143707738638718 0.428920690769677 no 1927 0.442865630042637 2627 1225414 SGTC_3157 9099274 49.47 µM -0.144718320543287 0.428522119124997 no 1928 0.442466636866934 2699 17217662 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.145055917859997 0.428388987586814 no 1929 0.442333361270482 2858 94937 An inhibitor of serotonin biosynthesis. SGTC_2914 7968218 45.32 µM -0.145421919382654 0.428244664054053 no 1930 0.442188879725466 2757 2977111 SGTC_2898 9056270 58.44 µM -0.145724443627917 0.428125378439606 no 1931 0.442069462063657 2644 19154699 SGTC_1233 0325-0408 14.2 µM -0.145864001167304 0.428070352974344 no 1932 0.442014375244362 2744 12874 SGTC_2750 bromebric acid 70.15 µM -0.146726533368864 0.427730300412084 no 1933 0.441673937331733 2779 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1756 st041558 35.5 µM -0.146853427448123 0.427680277055991 no 1934 0.441623856389866 2778 3955792 SGTC_2 0422-0095 29 µM -0.14850982770016 0.427027408670171 no 1935 0.440970215287792 2611 6790840 SGTC_1239 0337-0584 35.4 µM -0.148582310819109 0.42699884407716 no 1936 0.440941615989225 2811 914301 YML130C ERO1 SGTC_149 3970-0822 46.1 µM -0.149095151577976 0.426796751582729 no 1937 0.44073927580575 2658 3114250 YBL034C STU1 SGTC_655 k060-0012 42 µM -0.149804703679464 0.42651717376482 no 1938 0.44045934911956 2688 5994525 SGTC_1634 st006576 41 µM -0.150873047142281 0.426096294608927 no 1939 0.440037931170727 2765 3915356 SGTC_630 4356-0227 183 µM -0.151466006234226 0.425862731751138 no 1940 0.439804062259189 2682 779312 SGTC_1619 st003326 88.7 µM -0.152382496759491 0.425501783087336 no 1941 0.439442630709535 2841 2849032 SGTC_425 3825-7017 13.1 µM -0.15244429237008 0.425477447879638 no 1942 0.439418262512521 2931 3397440 SGTC_2763 lisinopril 49.32 µM -0.152749513195559 0.425357255608846 no 1943 0.439297906504017 2659 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2099 5377090 177.372 µM -0.156854372035545 0.423741490176075 no 1944 0.437679810234741 2760 2243829 SGTC_1899 st063254 59.6 µM -0.157134323558713 0.423631341280155 no 1945 0.437569493646429 2665 3093813 SGTC_2520 obtusaquinone 4.71 µM -0.157146293936875 0.423626631583639 no 1946 0.43756477675475 2847 5967872 SGTC_1886 st057356 49.9 µM -0.162045341340479 0.421700044799255 no 1947 0.435635074230499 2669 24207747 SGTC_1017 4239-0030 168 µM -0.162361443364715 0.421575799152679 no 1948 0.4355106158315 2724 1149593 SGTC_3018 9082602 49.47 µM -0.162842618166859 0.421386685730202 no 1949 0.435321175828921 2690 17332089 SGTC_1422 4031-0024 15.5 µM -0.1654723812173 0.420353446242604 no 1950 0.434286093372797 2682 782427 SGTC_1342 1486-1464 234 µM -0.167907454783303 0.419397189640949 no 1951 0.433328042663353 2714 3253938 SGTC_610 4215-0184 155 µM -0.168346939909095 0.419224653779901 no 1952 0.433155174031117 2770 5605015 SGTC_2896 9052656 71.43 µM -0.168645156808935 0.419107586738999 no 1953 0.43303787962362 2731 6469436 SGTC_440 fluspirilene 35.1 µM -0.168762963165057 0.419061343037766 no 1954 0.432991545756593 2951 3396 An atypical antipsychotic. SGTC_3106 9121286 49.47 µM -0.168778971579297 0.419055059181911 no 1955 0.432985249633128 2915 15943471 SGTC_1474 0330-0125 5.35 µM -0.169386604690441 0.418816557466383 no 1956 0.432746279585239 2742 X1474 SGTC_2373 9071805 200 µM -0.172903623315269 0.417436683324314 no 1957 0.431363591778942 2724 10149009 SGTC_783 0848-0141 92.7 µM -0.173151601718665 0.417339429131509 no 1958 0.431266132577249 2687 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3129 9127257 49.47 µM -0.174950958272295 0.416633894631616 no 1959 0.430559084389443 2744 837894 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.176751981029934 0.415927975629586 no 1960 0.429851604328052 2717 5106787 A p450 inhibitor. SGTC_1023 4482-3888 16 µM -0.176854906130322 0.415887641841571 no 1961 0.429811179939472 2927 3303168 SGTC_139 0099-0334 718.624 µM -0.177102761374985 0.41579051716959 no 1962 0.429713836474983 2706 97690 SGTC_2481 5478948 45.16 µM -0.177727653910394 0.415545669332929 no 1963 0.429468433154106 2849 77792 SGTC_512 prima-1 270 µM -0.178205251427979 0.415358557306461 no 1964 0.429280892847133 2887 322968 A re-activator of the apoptotic function of mutant p53. SGTC_941 3237-0776 460 µM -0.179301014755841 0.414929334340008 no 1965 0.428850675052534 2883 760008 SGTC_129 0088-0017 176.636 µM -0.180136747271894 0.414602036621887 no 1966 0.428522607150436 2767 182446 SGTC_1408 3909-7976 48.8 µM -0.180173635453087 0.414587591476999 no 1967 0.428508127782617 2761 24152374 SGTC_2415 st077333 57.7 µM -0.18171367006644 0.413984628366136 no 1968 0.427903718710847 2922 2766255 SGTC_2915 7971052 15.16 µM -0.182203988382767 0.413792698626037 no 1969 0.42771132155518 2714 5741558 SGTC_890 0929-0006 47.2 µM -0.182246292177135 0.4137761402329 no 1970 0.427694722674747 2744 1378169 SGTC_1744 st037937 38.9 µM -0.183552115884881 0.41326509513967 no 1971 0.427182415368235 2898 1016152 SGTC_2220 6782180 200 µM -0.183665531678342 0.413220715836895 no 1972 0.427137925298159 2735 833803 SGTC_395 anisomycin 6.25 µM -0.183714431800456 0.41320158168932 no 1973 0.427118743336208 2792 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3031 9088762 49.47 µM -0.183819161764521 0.413160602555101 no 1974 0.42707766168352 2705 205253 SGTC_2482 5981709 142.65 µM -0.184012947736463 0.413084779746444 no 1975 0.42700164877154 2811 877755 SGTC_2362 9071156 126 µM -0.184121624537433 0.413042259097097 no 1976 0.426959021278049 2904 653133 SGTC_2770 toltrazuril 17.5 µM -0.185531062817881 0.412490897912109 no 1977 0.42640625928336 2718 68591 Kills coccidiodes. SGTC_2367 9070478 135.38 µM -0.186085882357936 0.412273904160298 no 1978 0.426188706398884 2722 572802 SGTC_1182 1222-0449 220 µM -0.190126423939883 0.41069443321598 no 1979 0.424605032205698 2799 658318 SGTC_247 mechlorethamine 29.705 µM -0.190331201812876 0.410614422681917 no 1980 0.424524802502547 2738 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3162 9099653 49.47 µM -0.19037402310675 0.410597692073906 no 1981 0.42450802598896 2762 25237511 SGTC_2322 7413319 38.22 µM -0.19215933480033 0.409900302230169 no 1982 0.423808699184193 2874 1840400 SGTC_957 1187-1561 14.1 µM -0.194655005606747 0.408925905337296 no 1983 0.422831519174376 2726 1538454 SGTC_1678 st019265 80.2 µM -0.195745818260148 0.408500190371645 no 1984 0.422404560140293 2961 5367020 SGTC_1485 3909-9022 254 µM -0.195792280544548 0.408482059779838 no 1985 0.422386376185478 2751 714516 SGTC_1993 st073995 70.8 µM -0.196137535045577 0.408347340118467 no 1986 0.422251259036994 2770 3098394 SGTC_1687 st020778 55.3625 µM -0.197218357790171 0.407925668941776 no 1987 0.421828332647689 2784 4259299 SGTC_2745 rifampicin 24.3 µM -0.197221966848072 0.407924261085642 no 1988 0.421826920572568 2839 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1156 4092-0367 4.88 µM -0.197271545974309 0.407904920901988 no 1989 0.421807522412332 2787 1357585 SGTC_698 k064-0052 127 µM -0.199610150237919 0.406992916985326 no 1990 0.420892744401577 2725 5088751 SGTC_2041 5107442 45.335 µM -0.19977136309509 0.406930066054476 no 1991 0.420829699395557 2903 793005 SGTC_1800 st050079 29.0735 µM -0.201338857377049 0.406319083188982 no 1992 0.420216810411384 2858 3645560 SGTC_1040 k898-0338 155 µM -0.201572274917539 0.406228120434801 no 1993 0.420125560852242 2967 20969351 SGTC_681 1642-0006 26.6 µM -0.202380016904608 0.405913382684529 no 1994 0.41980982468737 2760 4446530 SGTC_2103 5378138 10 µM -0.203690181511389 0.405403004664229 no 1995 0.419297807683691 2755 244142 SGTC_103 0844-0104 51.839 µM -0.203931327434949 0.405309083141366 no 1996 0.419203581858681 2882 5375804 SGTC_2432 5630864 12.22 µM -0.205219444432655 0.404807479767594 no 1997 0.418700339140135 2920 5714970 SGTC_2336 9001819 198.65 µM -0.206231522853749 0.404413477747878 no 1998 0.41830503269418 2996 2989602 SGTC_1104 tacrolimus 29.8 µM -0.206708682526719 0.404227753133077 no 1999 0.418118688087224 2774 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2420 aureobasidin a 50 nM -0.207359996199115 0.403974277490436 no 2000 0.417864360996114 3064 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1199 1638-0010 4.46 µM -0.207623311186132 0.403871813057989 no 2001 0.417761550643361 2765 3111136 SGTC_454 lyso-paf C-16 6.67 µM -0.208682225555426 0.403459821675647 no 2002 0.417348158303705 2843 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1044 1222-0021 1.78 µM -0.209119999142799 0.403289528553027 no 2003 0.41717728139337 2899 4306703 SGTC_1311 1190-0148 100 µM -0.211150087881414 0.402500067935745 no 2004 0.416385078356149 2904 1961333 SGTC_2785 7756463 72.73 µM -0.211499026010496 0.402364412866591 no 2005 0.41624894607702 2791 2201551 SGTC_735 3076-0345 636 µM -0.213319684216627 0.401656795032758 no 2006 0.415538810550493 2933 2888990 SGTC_49 0717-0965 32.132 µM -0.213814250971289 0.401464632070147 no 2007 0.41534595563588 3073 5889349 YGL099W LSG1 SGTC_186 3455-3465 67.277 µM -0.214645936144257 0.401141536141299 no 2008 0.415021688346103 2770 755278 SGTC_102 gallobenzophenone 83.616 µM -0.2146565479561 0.401137414064253 no 2009 0.415017551260437 2968 70837 SGTC_185 k048-0037 25.491 µM -0.214802871558739 0.401080576903551 no 2010 0.414960506988487 2902 6827589 SGTC_2115 tiliquinol 12.7705 µM -0.214934660824537 0.401029387175071 no 2011 0.41490913046388 2897 71208 A bioactive hydroxyquinoline. SGTC_1854 st056233 32.9 µM -0.215058505570854 0.400981284813913 no 2012 0.414860852344839 2768 5393174 SGTC_564 3555-0129 330 µM -0.215282830496507 0.400894158912214 no 2013 0.414773407537737 2783 563260 SGTC_682 0kpi-0099 17 µM -0.215619259372418 0.400763502026405 no 2014 0.414642271053091 2874 1714895 YML126C ERG13 SGTC_919 tnp00227 403.569 nM -0.216402365684017 0.400459414692792 no 2015 0.41433706120445 2819 1269246 A methoxyflavone. YNL221C POP1 SGTC_847 0342-0274 5.54 µM -0.217868315057367 0.399890335453151 no 2016 0.413765857525674 2915 18097 SGTC_2810 7959871 45.46 µM -0.218287301826029 0.399727724453144 no 2017 0.413602633795798 2900 2974535 SGTC_1970 st070122 35.8 µM -0.218653743969648 0.399585520556344 no 2018 0.41345989199295 2962 102928 SGTC_1679 SEC14.276 6.7 µM -0.220000930548294 0.399062837293991 no 2019 0.412935214992819 2949 1005053 YMR079W SEC14 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.220800797449995 0.398752589395367 no 2020 0.412623771315109 2948 5282362 SGTC_3120 9124077 49.47 µM -0.221589872244443 0.398446590152769 no 2021 0.412316583644139 2755 18774327 YGL155W CDC43 SGTC_2888 9058547 12.99 µM -0.221679639747851 0.398411782717403 no 2022 0.412281640457059 2809 16476514 SGTC_1760 st045453 10.4495 µM -0.223331852133753 0.397771280391097 no 2023 0.411638619405106 2895 3323419 YIL048W NEO1 SGTC_713 1488-1073 324 µM -0.223821821536778 0.397581390048687 no 2024 0.411447974778243 2794 3312542 SGTC_1319 1306-0155 43.7 µM -0.224260082375617 0.397411560203943 no 2025 0.411277467404985 2797 3122360 SGTC_1641 st009299 47.1 µM -0.224362936274638 0.397371706249518 no 2026 0.411237454054324 2811 4046054 SGTC_1068 loratadine 26.9 µM -0.224849778168708 0.397183078702162 no 2027 0.411048070022656 2851 3957 A H1 histamine antagonist. SGTC_1732 st034308 51.822 µM -0.224884038650294 0.397169805337594 no 2028 0.411034743297183 2740 830119 SGTC_711 k292-0785 179 µM -0.225633591205461 0.396879439825719 no 2029 0.410743206243045 2778 4146315 SGTC_2539 epi(13)torulosol 80 µM -0.22837795415773 0.395816803365586 no 2030 0.409676213329214 2912 6708597 SGTC_580 1123-0028 41 µM -0.229731351423057 0.395293042933798 no 2031 0.409150265733056 2800 1677248 YPR107C YTH1 SGTC_61 0978-8327 98.565 µM -0.229917063980182 0.395221187498626 no 2032 0.409078108179742 2801 6150059 YHR072W ERG7 SGTC_1494 4358-1428 177 µM -0.230619789638852 0.394949322920812 no 2033 0.408805096044659 2950 1564571 SGTC_2048 5246248 200 µM -0.231631275526497 0.394558097596146 no 2034 0.40841220684982 2900 677046 SGTC_85 0868-0259 160.055 µM -0.231967598315675 0.394428037267145 no 2035 0.40828159011407 2874 83173 SGTC_1610 st001799 48.1 µM -0.233067581530588 0.394002741934061 no 2036 0.407854463963667 2787 621897 SGTC_2729 fluphenazine 10.66 µM -0.233578956365407 0.393805067980285 no 2037 0.407655933127139 2812 3372 An atypical antipsychotic. SGTC_1434 4073-0095 163 µM -0.234190913753724 0.393568549410124 no 2038 0.407418384339557 2840 24133745 SGTC_709 3807-1509 243 µM -0.234242196176368 0.393548730783747 no 2039 0.407398479143136 2782 1886677 YPL242C IQG1 SGTC_2955 9076254 12.21 µM -0.234987808056562 0.393260612485258 no 2040 0.407109098032213 2935 16459619 SGTC_318 1488-0629 67.2 µM -0.236059258377683 0.392846686533296 no 2041 0.406693343838867 2901 3662576 SGTC_2762 leflunomide 42.06 µM -0.236833829426031 0.392547527301787 no 2042 0.406392852975347 2816 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2080 5212524 12.4 µM -0.236966814099656 0.392496171585442 no 2043 0.406341267792839 2855 260183 SGTC_2491 paeonol 100 µM -0.237307574485555 0.392364586066712 no 2044 0.406209093164873 2782 11092 Increases levels of cortical cytochrome oxidase. SGTC_3150 9097574 49.47 µM -0.23764548440872 0.392234113412824 no 2045 0.406078034732586 2964 17217476 SGTC_3153 9100258 49.47 µM -0.237646227892442 0.392233826354717 no 2046 0.406077746383872 2848 25236848 SGTC_1176 0848-0131 83.3 µM -0.237881796420664 0.39214287660335 no 2047 0.405986387323283 2919 6769040 SGTC_250 brefeldin a 552.239 µM -0.238580979959562 0.391872966222548 no 2048 0.405715257534476 2809 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1098 clofazimine 15.1 µM -0.239965124979529 0.391338789266455 no 2049 0.405178646496162 2935 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1218 1348-1416 30.7 µM -0.24018692663217 0.391253209356492 no 2050 0.405092674059435 2811 6787668 SGTC_1067 clotrimazole 1.36 µM -0.240786957849512 0.391021719814538 no 2051 0.404860119200237 2836 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_741 4582-0002 126 µM -0.241104327293525 0.3908992956108 no 2052 0.404737129502293 2820 2912688 SGTC_2841 9004761 38.96 µM -0.241200992056474 0.390862009648586 no 2053 0.404699671022866 2844 2991039 SGTC_2936 9038235 15.59 µM -0.243057781457932 0.390145995696269 no 2054 0.403980318050435 2820 4749415 SGTC_2263 7948595 193.29 µM -0.243428142536936 0.390003221776873 no 2055 0.403836872387053 2829 2971371 SGTC_948 3448-0295 75.3 µM -0.243565321977414 0.389950342969768 no 2056 0.403783744286437 2824 678569 SGTC_888 0916-0002 6.97 µM -0.243601684831139 0.389936326456186 no 2057 0.403769661647514 3004 2802138 YIL048W NEO1 SGTC_3 0833-0587 95.581 µM -0.243775279915615 0.389869414047651 no 2058 0.403702433305553 2886 5382644 SGTC_2932 9016711 44.54 µM -0.244034373377815 0.389769552270213 no 2059 0.403602099213659 2956 7117328 SGTC_1848 st056003 16.4 µM -0.244225817060758 0.389695769260569 no 2060 0.40352796661265 2838 146492 SGTC_2883 9059145 45.46 µM -0.245186242743316 0.389325678165317 no 2061 0.403156114021408 2783 16476510 SGTC_1856 st057054 55.7 µM -0.245264438171904 0.38929555069889 no 2062 0.40312584257454 3092 1266018 SGTC_1275 0867-0008 21.1 µM -0.245717452675788 0.389121024449474 no 2063 0.402950480523652 2825 3422836 SGTC_851 0394-0702 453 µM -0.246004886092743 0.389010300791767 no 2064 0.402839225080565 2970 762646 SGTC_864 0469-0573 172 µM -0.24601241369367 0.389007401168212 no 2065 0.40283631151466 2825 689425 SGTC_1475 4092-1048 11.7 µM -0.246240677992136 0.388919476949538 no 2066 0.402747964139579 2918 2881759 SGTC_1707 st032323 6.317 µM -0.246684831644005 0.388748411475811 no 2067 0.402576073221287 2850 3132057 YMR211W DML1 SGTC_320 4092-0846 5.34 µM -0.24721723540607 0.388543384959692 no 2068 0.402370053643523 2932 1359356 SGTC_3177 9107506 49.47 µM -0.247853639868768 0.388298348939 no 2069 0.402123825415171 2962 8897194 SGTC_3160 9100216 49.47 µM -0.249125939670858 0.387808606288564 no 2070 0.401631682464075 2813 17191039 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.249135471421818 0.387804937931853 no 2071 0.401627996040215 2829 91467 include heat shock SGTC_268 camptothecin 39.6153 µM -0.249245501793974 0.387762592748383 no 2072 0.401585442206279 2867 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1404 3909-7820 48.3 µM -0.251662594239078 0.38683271240817 no 2073 0.400650936015665 2946 23741373 SGTC_337 1315-0038 354 µM -0.25296309112212 0.38633266616005 no 2074 0.400148367387703 2870 1626437 SGTC_1908 st060353 56.5 µM -0.253431003747511 0.38615279800878 no 2075 0.399967585969645 3061 4227716 SGTC_2713 st079149 53.4 µM -0.255267326470612 0.38544714235206 no 2076 0.399258316930538 2940 3103253 SGTC_2014 4013930 200 µM -0.25540444566202 0.38539446585006 no 2077 0.399205368744334 2885 64556 SGTC_2408 sulbentine 18.36 µM -0.257023949648017 0.384772468024274 no 2078 0.398580142417571 2912 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.259047558416545 0.383995683723406 no 2079 0.397799273108505 2798 4000243 SGTC_882 0843-0131 351 µM -0.259181828183009 0.38394415925353 no 2080 0.397747475591558 2849 5425421 SGTC_3140 9094243 49.47 µM -0.259394216465273 0.383862661895856 no 2081 0.397665545819223 2832 19291112 SGTC_1215 3852-0577 11.2 µM -0.259475226881439 0.383831578036419 no 2082 0.39763429686158 3021 2884876 SGTC_2378 9074213 121.43 µM -0.259523676887145 0.383812988029053 no 2083 0.397615608070437 2869 657714 SGTC_507 nimesulide 162 µM -0.259849625310765 0.383687930319078 no 2084 0.397489884948588 3056 4495 A COX2 inhibitor. SGTC_779 1360-0071 233 µM -0.26046436220425 0.383452105158948 no 2085 0.397252800836331 3057 7566 SGTC_270 tamoxifen 5.46 µM -0.260500943349263 0.383438073272515 no 2086 0.397238693869108 3063 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_428 3448-4153 16.5 µM -0.261422531823199 0.383084618567317 no 2087 0.396883341565158 2805 3834874 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.261431707160331 0.383081100060181 no 2088 0.396879804106645 2862 165521 SGTC_1924 st058459 75.1 µM -0.261789077645948 0.382944065125713 no 2089 0.39674203013143 2833 688683 SGTC_1758 st042942 75.2445 µM -0.261948839550389 0.382882808614679 no 2090 0.396680442663956 2862 669317 SGTC_3311 9131146 2.8755 µM -0.262266432449665 0.382761044649849 no 2091 0.396558019741424 2909 4900406 YPR165W RHO1 SGTC_1992 st073643 23.3 µM -0.263924045301307 0.382125710212367 no 2092 0.395919223448542 2841 3161292 SGTC_2086 5274770 176.623 µM -0.263966025828416 0.382109623912027 no 2093 0.395903048982212 2950 689278 SGTC_1354 1498-1681 81 µM -0.264250174570854 0.382000747781593 no 2094 0.395793575454781 2961 5754243 SGTC_562 3772-2733 112 µM -0.266163972125447 0.381267689147575 no 2095 0.395056464282902 2990 2876874 YIL048W NEO1 SGTC_145 3737-0113 38.366 µM -0.266694977938702 0.38106436869154 no 2096 0.39485201047081 3009 6849351 SGTC_1921 5740136 50 µM -0.266826659693205 0.381013953239945 no 2097 0.394801313363207 3086 1774243 SGTC_784 4579-0127 173 µM -0.266942360555864 0.380969657872216 no 2098 0.394756770324418 3072 1948547 SGTC_1237 0330-0133 46.1 µM -0.267304856875139 0.380830888474578 no 2099 0.394617223769714 2859 X1237 YHR072W ERG7 SGTC_1987 st072290 61.9 µM -0.267960111898617 0.380580085261615 no 2100 0.394365011168986 2929 54697379 SGTC_2229 7354935 190 µM -0.268234339096106 0.380475137869636 no 2101 0.394259472190031 2968 318112 SGTC_1343 1487-0095 224 µM -0.268596897869688 0.380336399280169 no 2102 0.394119949870547 2984 4560101 YGL055W OLE1 SGTC_702 1488-0190 94 µM -0.268638051498454 0.38032065219513 no 2103 0.394104113711067 2972 949357 SGTC_1454 4239-0054 42.6 µM -0.268644330824094 0.380318249482172 no 2104 0.394101697404857 3070 1340767 SGTC_208 k072-0098 12.366 µM -0.268812357695917 0.38025395761481 no 2105 0.394037041597932 2864 5948901 SGTC_184 1494-0393 24.714 µM -0.268856702971695 0.380236990400822 no 2106 0.394019978269132 2850 3090647 SGTC_1287 0971-0001 34.6 µM -0.269817132596072 0.379869571214016 no 2107 0.393650470800403 2906 4665869 SGTC_1660 st012960 28.1 µM -0.270409328525362 0.379643076457903 no 2108 0.393422682106898 2974 24207266 SGTC_1891 st059073 26.2 µM -0.271352070835472 0.379282594873232 no 2109 0.393060130715005 3088 688754 SGTC_411 enrofloxacin 100 µM -0.272966518717013 0.378665513388694 no 2110 0.392439476359516 3044 71188 A bacterial gyrase inhibitor. SGTC_1204 4049-0315 18.3 µM -0.275464221598724 0.377711439960481 no 2111 0.391479804960735 3138 588402 SGTC_715 0868-0130 184 µM -0.276044742972597 0.377489798771449 no 2112 0.391256850440217 3065 2876258 SGTC_1 0258-0098 57.368 µM -0.276233107719479 0.37741789038312 no 2113 0.391184514917055 2947 6790032 YDR047W HEM12 SGTC_1574 spiramycin 23.7 µM -0.276253548368552 0.377410087405013 no 2114 0.391176665558635 2854 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3086 9117350 49.47 µM -0.279057342610235 0.37634024731579 no 2115 0.390100409423211 2871 2679265 SGTC_3174 9107204 49.47 µM -0.281140205454664 0.37554610613542 no 2116 0.389301432364789 3032 3938802 SGTC_2363 9053361 176 µM -0.282652431064125 0.374969864025663 no 2117 0.3887216421322 3070 6469797 YMR079W SEC14 SGTC_77 0828-0286 12.516 µM -0.282675849376026 0.374960942536065 no 2118 0.38871266545102 2871 745345 SGTC_3219 9131112 49.47 µM -0.28307959602494 0.374807140883373 no 2119 0.388557911083824 2996 17612988 YMR079W SEC14 SGTC_3287 9117173 37.0625 µM -0.283619740727501 0.374601411434281 no 2120 0.388350903586887 2963 2789709 SGTC_334 1502-1024 68.5 µM -0.284538433817728 0.37425158308135 no 2121 0.387998892357572 2987 3296216 SGTC_746 1095-0025 46.6 µM -0.285051840241202 0.374056128558756 no 2122 0.387802212935984 3088 6749286 SGTC_1720 st037298 9.481 µM -0.285156826337817 0.374016164194503 no 2123 0.387761997650706 2995 597396 SGTC_2302 7771753 200 µM -0.285433596968282 0.373910814237257 no 2124 0.387655985480661 2985 2203047 SGTC_856 0433-0016 11.3 µM -0.285700765742908 0.373809128063498 no 2125 0.387553659078025 2993 3911780 SGTC_258 haloperidol 50.781 µM -0.286388046974179 0.373547584727362 no 2126 0.38729046431094 2951 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1618 st003135 44.5 µM -0.286458136513037 0.373520915580178 no 2127 0.387263626387954 2872 1270615 SGTC_683 panaxydol 45 µM -0.287245057942906 0.373221532709411 no 2128 0.386962344017702 2940 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1950 st077106 7.18 µM -0.290301534733735 0.372059428847674 no 2129 0.385792782416529 3009 13831864 SGTC_996 3970-0799 1.8 µM -0.29034907283123 0.372041363543996 no 2130 0.385774600117903 2972 6615648 YGL040C HEM2 SGTC_2878 9043973 25.97 µM -0.29103485868117 0.371780784354778 no 2131 0.385512329740551 3063 6465167 SGTC_2941 9056145 11.23 µM -0.29220990654316 0.371334436048282 no 2132 0.385063068850226 2911 2119517 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.292310447264761 0.371296253134939 no 2133 0.385024635856727 3100 1273210 SGTC_3185 9108267 49.47 µM -0.292948541442198 0.371053950077625 no 2134 0.384780742436678 2996 4910486 SGTC_2255 7941087 197.44 µM -0.293805465128276 0.370728631467173 no 2135 0.384453279370827 3080 935561 SGTC_2360 9040895 200 µM -0.295872674074704 0.369944226360428 no 2136 0.383663660089353 2982 4914414 SGTC_1337 1486-1011 40.3 µM -0.296763711114624 0.369606287782273 no 2137 0.383323456170631 2933 X1337 SGTC_1439 4092-1168 46 µM -0.297164999696984 0.36945412620346 no 2138 0.383170270859598 2991 2886240 SGTC_1904 st060225 78 µM -0.297997054292705 0.369138690893522 no 2139 0.382852705941077 2932 66595 SGTC_500 h-89 112 µM -0.298182516072488 0.369068393571751 no 2140 0.382781932661144 3107 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2951 9072950 58.06 µM -0.298465547993894 0.368961121763409 no 2141 0.382673933599622 2934 16488155 SGTC_617 3770-0098 35 µM -0.298807727610853 0.368831446041245 no 2142 0.382543377197101 2946 5962639 SGTC_1194 1488-0194 225 µM -0.299887720359571 0.368422259462953 no 2143 0.382131400618957 2902 1391452 SGTC_877 0771-0151 33.1 µM -0.300548840249458 0.368171848595679 no 2144 0.381879274069399 3026 6166523 SGTC_2040 5100729 123 µM -0.300578141900708 0.368160751371499 no 2145 0.381868100667407 2930 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_780 0109-0199 192 µM -0.304127356183676 0.366817396655521 no 2146 0.380515433060646 3124 610414 SGTC_2155 5570423 76 µM -0.305215421699852 0.366405896440557 no 2147 0.380101043815779 2957 797402 SGTC_3041 9091929 49.47 µM -0.306949766218434 0.365750294768625 no 2148 0.37944080415074 3126 25236887 SGTC_1088 bifonazole 369 nM -0.307285360986177 0.365623481378423 no 2149 0.379313088636254 3006 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_659 k018-0002 107 µM -0.307310052774145 0.365614151510804 no 2150 0.379303692333914 3083 6797879 YHR007C ERG11 SGTC_1096 rimcazole 32.2 µM -0.308351273412641 0.365220795531428 no 2151 0.378907527424654 2925 18528119 A dopamine reuptake inhibitor. SGTC_2975 9084847 53.72 µM -0.310665400270357 0.364347064743468 no 2152 0.378027501569557 3034 27211724 SGTC_8 0354-0001 70 µM -0.311907845979989 0.363878252409399 no 2153 0.37755527976959 2981 4993152 SGTC_2505 galangin 7.89 µM -0.312312371953088 0.363725656449059 no 2154 0.377401569256941 2905 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2899 9053889 58.44 µM -0.312939934272834 0.363488969127804 no 2155 0.37716314852921 3074 6470052 SGTC_1985 st071382 65.5 µM -0.314876377259025 0.362758961654279 no 2156 0.376427759083008 2979 6123237 SGTC_2773 thioridazine 9.09 µM -0.315203938785819 0.362635525517413 no 2157 0.3763034075849 2964 5452 An antipsychotic. SGTC_2175 5807670 165.306 µM -0.315251788692981 0.362617495266963 no 2158 0.376285243499018 3089 241186 SGTC_189 3970-0742 2.116 µM -0.316126397793604 0.362287988858992 no 2159 0.37595328542406 2993 2891807 SGTC_191 3914-0123 66.505 µM -0.316848120610598 0.362016158715248 no 2160 0.375679424470219 2934 3144412 SGTC_156 3474-0145 5.642 µM -0.31756203137621 0.361747339365603 no 2161 0.375408589439179 2963 2265471 SGTC_824 1304-0008 100 µM -0.318127800261478 0.361534350502365 no 2162 0.375193998324668 2976 768245 SGTC_3195 9113082 49.47 µM -0.318877775147394 0.361252081739092 no 2163 0.37490959904834 3059 17018038 SGTC_1190 1486-1332 13 µM -0.318984458442687 0.361211935377454 no 2164 0.374869149012639 3028 4150046 SGTC_2228 7354201 200 µM -0.320374801398944 0.360688870498415 no 2165 0.374342112627377 2999 753451 SGTC_1333 1482-0047 286 µM -0.321373283869995 0.360313389230266 no 2166 0.373963763286389 3111 3811116 SGTC_1138 3761-0006 1.03 µM -0.322136047621285 0.360026641167277 no 2167 0.373674815279606 2976 12061087 SGTC_3026 9090633 49.47 µM -0.32302954504424 0.359690846158529 no 2168 0.373336433407413 2957 25236842 SGTC_3346 9158254 43.5805 µM -0.323607972262549 0.359473518845224 no 2169 0.373117425754911 3064 17639500 SGTC_3105 9121040 49.47 µM -0.32400944715684 0.359322702968713 no 2170 0.372965440969146 3004 41448907 SGTC_1731 st035964 63 µM -0.324476270073117 0.359147366366369 no 2171 0.372788742496684 2986 6739575 SGTC_1145 3546-0597 10.2 µM -0.324494531137151 0.359140508194927 no 2172 0.372781830993 3020 875334 SGTC_1556 plumbagin 1.48 µM -0.324601854062294 0.359100202642831 no 2173 0.372741211909904 2996 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1817 st052116 64.4 µM -0.32586328282835 0.358626585697067 no 2174 0.372263898368453 3109 4361398 SGTC_174 3553-0389 74.3 µM -0.328538730151493 0.357622780403213 no 2175 0.371252182730592 3125 738071 SGTC_1565 sinapyl alcohol 95.1 µM -0.328745223787339 0.357545346549438 no 2176 0.371174134397995 3078 5280507 A phenol propionate derived from cinnamic acid. SGTC_2082 5219693 150 µM -0.32963154556573 0.357213047925215 no 2177 0.370839191853881 2976 2834649 SGTC_2071 5230951 39.92 µM -0.329713149350675 0.357182458577941 no 2178 0.370808358556703 3055 1799272 SGTC_1769 st044406 64.4 µM -0.330342894046107 0.356946428365344 no 2179 0.370570442788379 2969 670903 SGTC_1699 st031318 29.054 µM -0.333382960928321 0.355807773626984 no 2180 0.369422611714701 3100 5340658 SGTC_3350 9150499 3.57 µM -0.334368280164427 0.355438998343536 no 2181 0.369050836038251 2959 4910996 YPR165W RHO1 SGTC_3334 9142812 21.919 µM -0.335390644348679 0.355056501279173 no 2182 0.368665212211202 3105 45283678 SGTC_931 2812-0076 566 µM -0.335930367891723 0.354854633399696 no 2183 0.368461688092053 2958 3450959 SGTC_2093 5331342 194.4 µM -0.33756328010887 0.354244138434543 no 2184 0.36784615882625 3141 33839 SGTC_921 1561-0023 372 µM -0.337634322268463 0.354217586473595 no 2185 0.367819387042461 2971 24050882 SGTC_2700 st077718 96.8 µM -0.337885998317686 0.354123528417157 no 2186 0.367724549699661 3057 904970 SGTC_2626 ethyl orsellinate 100 µM -0.33822008674862 0.353998684402993 no 2187 0.367598669928523 2978 75653 A natural product. SGTC_278 4092-0821 23.9 µM -0.338872640273307 0.353754879865871 no 2188 0.367352838070819 3078 877900 SGTC_849 0386-0493 241 µM -0.339731953437375 0.353433918077778 no 2189 0.36702919805398 2981 726119 SGTC_2009 4012297 12.05 µM -0.340482900728469 0.353153517296061 no 2190 0.366746448827475 3102 45595307 SGTC_2386 9075165 157.42 µM -0.34203600719196 0.352573846464655 no 2191 0.366161897410336 2991 16452277 SGTC_138 0850-0259 40.9225 µM -0.342652729651034 0.352343760032656 no 2192 0.365929864151372 3093 6813004 SGTC_2122 5258151 111.688 µM -0.342815431724688 0.352283068247528 no 2193 0.365868657926362 3022 2173356 SGTC_2561 acetosyringone 100 µM -0.342926352884573 0.352241694144409 no 2194 0.365826932907584 2970 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2944 9067346 25.62 µM -0.344425777785625 0.351682573530889 no 2195 0.365263052785441 3172 6473075 SGTC_1799 st045822 46.1415 µM -0.344701310640508 0.351579864914597 no 2196 0.365159466356862 3158 3674992 SGTC_457 grayanotoxin iii 135 µM -0.345357004489507 0.351335489700887 no 2197 0.364912998181863 3093 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3252 9135871 49.47 µM -0.345969139626778 0.351107404148643 no 2198 0.364682953618473 3160 17682838 SGTC_2076 5212012 200 µM -0.346567836359921 0.350884377705048 no 2199 0.364458006419801 3000 604802 SGTC_2478 5763493 32.33 µM -0.347688824628269 0.350466925453716 no 2200 0.364036945157394 3009 1365576 YLR208W SEC13 SGTC_1938 st074717 56.4 µM -0.349499441256034 0.349793039402446 no 2201 0.363357195107712 2951 17250979 SGTC_654 1124-0271 80.9 µM -0.349847618498909 0.349663506878601 no 2202 0.363226530036317 3043 5403748 SGTC_2130 NSC 7 2.4545 µM -0.351951312912222 0.34888124134212 no 2203 0.36243738793312 3127 21448 SGTC_2339 9000433 200 µM -0.351968772059725 0.348874751783216 no 2204 0.36243084106193 3063 2988954 SGTC_818 4072-2707 53.5 µM -0.352571536503659 0.348650731575457 no 2205 0.362204839750306 2962 882871 SGTC_976 1348-1067 47.6 µM -0.352788600765126 0.348570071551434 no 2206 0.362123465141342 3025 5310671 YGL099W LSG1 SGTC_2681 menadione 3.18 µM -0.353593142067511 0.348271167650356 no 2207 0.361821907297388 3116 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3313 9133968 57.047 µM -0.355136105273923 0.347698188320803 no 2208 0.361243814593367 3009 1494643 SGTC_167 3672-0051 66.205 µM -0.355553149109917 0.347543378744911 no 2209 0.361087617614311 2965 3237971 SGTC_489 paxilline 115 µM -0.356494208061938 0.347194144550484 no 2210 0.360735244432148 3096 105008 A toxic potassium channel blocker. SGTC_591 4299-0174 154 µM -0.357617652630236 0.346777395532123 no 2211 0.360314732983963 3075 5509088 SGTC_533 1222-0222 6.71 µM -0.358788197297935 0.346343371559777 no 2212 0.359876771400861 3198 3982874 SGTC_635 k038-0028 24.7 µM -0.360264926295996 0.345796105870656 no 2213 0.35932451275509 3076 4035102 SGTC_893 0958-0369 48.9 µM -0.361402655883019 0.345374690605283 no 2214 0.358899231437925 3160 6819948 SGTC_761 k216-0224 480 µM -0.361788373466621 0.345231864201208 no 2215 0.358755090543278 3221 1340404 SGTC_283 0987-0079 11.7 µM -0.36198068651943 0.345160661312098 no 2216 0.358683231548962 3143 411556 SGTC_405 ebelactone b 50 µM -0.362766508711011 0.344869771787774 no 2217 0.358389656097871 3053 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1942 st076330 65.2 µM -0.364730709991034 0.344143080345773 no 2218 0.357656216115721 3178 24208414 SGTC_150 3970-0969 77.2 µM -0.364973305916856 0.344053367490793 no 2219 0.357565666297812 3149 6615640 SGTC_3249 9135183 49.47 µM -0.365026726714203 0.344033613464831 no 2220 0.357545727866435 3194 4902779 SGTC_3061 glucosamine 200 µM -0.365841316214539 0.343732446045304 no 2221 0.35724174396731 3147 91431 and experimental redox chemotherapeutic SGTC_2570 licareol 100 µM -0.366781169426113 0.343385089720318 no 2222 0.35689112741709 3111 443158 SGTC_2741 miltefosine 3.04 µM -0.367584844355599 0.343088167817691 no 2223 0.356591408637367 3051 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_475 α-linolenic acid 10 µM -0.368020554385131 0.342927232948389 no 2224 0.356428953968939 3276 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3152 9099253 49.47 µM -0.368359243395235 0.342802153669802 no 2225 0.356302691620366 3108 25236131 SGTC_2614 arthonioic acid 13.39 µM -0.368435444413686 0.342774014686376 no 2226 0.356274286256575 3044 6710684 SGTC_2474 5321570 43.32 µM -0.36935565810559 0.342434273467621 no 2227 0.355931322289522 3152 2841384 SGTC_2205 7238770 200 µM -0.371732982102198 0.341557160300582 no 2228 0.355045832895312 3188 279867 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.371811441628557 0.341528227223457 no 2229 0.355016622136851 3181 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2453 5731132 22.18 µM -0.372106084228638 0.341419581849065 no 2230 0.354906933267278 3202 1362040 SGTC_379 3970-0972 5.9 µM -0.372951073033716 0.341108076845898 no 2231 0.35459242950177 3112 2898042 YBL034C STU1 SGTC_2504 purpurogallin 52.29 µM -0.373057784811321 0.341068745259518 no 2232 0.354552718556581 3024 5281571 An antioxidant. SGTC_225 nsc-122657 1.016 µM -0.373713676243824 0.340827036216086 no 2233 0.354308674620375 3157 275685 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.374004853084223 0.340719752690015 no 2234 0.354200352772282 3222 688798 SGTC_1158 4092-0494 91.8 µM -0.374771105065357 0.340437490254123 no 2235 0.353915352727026 3196 1148199 SGTC_814 3342-0569 96 µM -0.374779373091036 0.340434445068021 no 2236 0.353912277960492 3114 4346283 SGTC_1015 4130-4525 82 µM -0.37528250442224 0.340249156988003 no 2237 0.353725188184518 3076 1363237 SGTC_1171 0368-0077 21.4 µM -0.377642140028375 0.339380689618444 no 2238 0.35284822780894 3051 3239779 SGTC_913 3487-1245 167 µM -0.378208945521333 0.339172202817149 no 2239 0.352637690306456 3012 4016153 SGTC_2650 prasterone 100 µM -0.379267965951159 0.338782797662363 no 2240 0.352244442621536 3127 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2671 danthron 100 µM -0.379508131727323 0.338694511893663 no 2241 0.352155283448105 3131 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3202 9113761 49.47 µM -0.379644088586326 0.338644537610888 no 2242 0.352104814408223 3203 4798415 SGTC_1604 st002052 72.4 µM -0.380487579859795 0.33833455518988 no 2243 0.35179175719034 3198 6254834 YHR062C RPP1 SGTC_1100 amiodarone 5.07 µM -0.380701374777499 0.338256003106856 no 2244 0.351712424314828 3165 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1191 1487-1166 10.6 µM -0.380914284701819 0.338177783182076 no 2245 0.351633426250551 3186 3955771 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.38141607240496 0.337993461510706 no 2246 0.351447268368985 3094 688669 SGTC_549 1661-1316 519 µM -0.384272258824334 0.336945039333751 no 2247 0.350388333391969 3221 2857282 SGTC_2035 5154463 94.595 µM -0.384739411697875 0.336773681437611 no 2248 0.350215246168938 3231 2769623 SGTC_1248 0469-0687 58.6 µM -0.385873577338428 0.33635779540804 no 2249 0.349795150102421 3176 4017482 SGTC_2344 7990960 76.95 µM -0.386841423359691 0.33600305519603 no 2250 0.34943680432455 3098 140813 SGTC_2489 cantharidin 73.42 µM -0.387274652760901 0.335844312881218 no 2251 0.349276444229519 3080 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3139 9095020 49.47 µM -0.387877392093602 0.335623508078238 no 2252 0.349053384699512 2997 25236292 SGTC_570 0987-0065 62.6 µM -0.389203357859056 0.335137959592759 no 2253 0.348562859846914 3062 3104428 SGTC_1662 st014054 52 µM -0.390688483960074 0.334594455930176 no 2254 0.348013756075622 3120 2838777 SGTC_908 3448-7491 47.7 µM -0.392146059871835 0.334061371458166 no 2255 0.347475148281221 3073 1203031 SGTC_2053 5265679 138 µM -0.394647830705462 0.333147170321786 no 2256 0.346551404480132 3066 764595 SGTC_1862 st057513 3.81 µM -0.395364811503051 0.332885352423988 no 2257 0.346286837220024 3063 5393163 SGTC_66 0109-0187 42.4 µM -0.397266687230622 0.332191244616764 no 2258 0.345585405082083 3160 759417 SGTC_1882 5615643 20 µM -0.397371749731982 0.332152917794457 no 2259 0.34554667232765 3175 2253075 SGTC_2704 st078022 71.1 µM -0.397470736994067 0.332116808826996 no 2260 0.345510180774248 3255 54697681 SGTC_952 1185-0122 232 µM -0.398443571847504 0.331762017240652 no 2261 0.345151622633842 3078 678600 SGTC_1026 k007-1105 30.6 µM -0.399912627822945 0.331226540412665 no 2262 0.344610435515811 3107 7066794 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.399987289324967 0.331199335195695 no 2263 0.344582939363653 3343 6710655 SGTC_2063 5246145 200 µM -0.40005571501311 0.331174402971951 no 2264 0.344557740442624 3217 711240 SGTC_3050 9093513 49.47 µM -0.400109359854206 0.33115485695928 no 2265 0.344537985301762 3122 25236664 SGTC_2377 9073351 62.6 µM -0.400764686066758 0.330916119716904 no 2266 0.344296690436439 3091 7337946 YHR072W ERG7 SGTC_958 1222-0007 33 µM -0.400920212318265 0.330859471141474 no 2267 0.344239434079829 3267 7312461 SGTC_2284 7945075 39.21 µM -0.402970641781815 0.330112989281064 no 2268 0.343484911049757 3235 1245402 SGTC_625 k213-0058 121 µM -0.403180353697084 0.330036679350151 no 2269 0.34340777572886 3184 3655420 SGTC_1359 1582-0056 520 nM -0.403275959528395 0.330001892665317 no 2270 0.343372612573612 3202 3661189 SGTC_1920 st075728 45.7 µM -0.40383794925565 0.329797439468783 no 2271 0.343165944102838 3266 3400306 SGTC_2586 curcumin 80 µM -0.404192604878326 0.3296684410744 no 2272 0.343035545682945 3212 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2182 6325192 200 µM -0.404624226794975 0.329511475172115 no 2273 0.342876873808207 3215 736248 SGTC_1305 1181-0477 144 µM -0.405945007176281 0.329031339877138 no 2274 0.342391503736455 3248 6252086 SGTC_1514 1189-1591 158 µM -0.406323616323872 0.328893758342997 no 2275 0.342252417614688 3285 767698 YMR146C TIF34 SGTC_2648 atorvastatin 78.68 µM -0.406911395098429 0.328680213278805 no 2276 0.342036533188582 3217 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1712 st032288 53.4 µM -0.407656121494891 0.328409728129454 no 2277 0.341763077849228 3207 2883011 SGTC_1232 0279-0259 161 µM -0.40771560764633 0.328388126593398 no 2278 0.341741238767139 3156 1560000 SGTC_2038 4100038 30.985 µM -0.40885618486337 0.327974053488311 no 2279 0.341322602485899 3206 3596803 SGTC_2232 chlorophetanol 41.5365 µM -0.4114359196132 0.327038291468741 no 2280 0.34037645997209 3229 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2234 tolnaftate 200 µM -0.411720564285513 0.326935107114403 no 2281 0.340272125191008 3163 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2783 7738165 71.43 µM -0.413164182149174 0.32641199613546 no 2282 0.339743164201025 3183 17201110 SGTC_1136 pergolide 1.05886 µM -0.41341225828212 0.326322137320211 no 2283 0.33965229750307 3080 47811 A dopamine receptor agonist. SGTC_841 0251-0215 91.2 µM -0.417009635614326 0.325020220603267 no 2284 0.338335679912664 3200 3888614 SGTC_183 3914-0051 30.55 µM -0.417115027043012 0.324982110784182 no 2285 0.338297136998145 3257 1596232 SGTC_1202 1988-0068 29.6 µM -0.41719774450638 0.324952201213491 no 2286 0.338266887412507 3129 2850480 SGTC_2779 methotrexate 400 µM -0.418186112223648 0.324594907485299 no 2287 0.337905524420321 3247 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2050 5263056 171 µM -0.419291149018073 0.324195629089507 no 2288 0.337501682176557 3276 763468 YGL055W OLE1 SGTC_600 1495-0418 41.6 µM -0.41968675338779 0.324052736094698 no 2289 0.337357151668048 3144 5377768 SGTC_385 1494-0393 12.4 µM -0.421767203587476 0.323301700788158 no 2290 0.33659747317023 3168 3090647 SGTC_2111 5486399 200 µM -0.422938816175715 0.322879069180943 no 2291 0.336169950743706 3163 689674 SGTC_1031 k035-0009 16 µM -0.4233323618879 0.322737158117252 no 2292 0.336026393074933 3292 5180959 SGTC_2210 7115885 190.385 µM -0.426988550714436 0.321419986673941 no 2293 0.334693833474494 3179 2927039 SGTC_2402 5553605 200 µM -0.426991278180052 0.321419004917578 no 2294 0.33469284017782 3325 6758546 SGTC_910 3454-3003 490 µM -0.428371151593764 0.320922476993923 no 2295 0.334190462172017 3278 820824 SGTC_2920 7982904 15.77 µM -0.429800202683061 0.320408590569 no 2296 0.333670492718153 3218 6456808 SGTC_3000 9075062 71.4286 µM -0.430833083454371 0.320037381089285 no 2297 0.333294871113315 3156 17057871 SGTC_1879 gemcitabine 100 µM -0.430849602311945 0.320031445799934 no 2298 0.333288865155492 3164 60750 A nucleoside analog which inhibits DNA replication. SGTC_2690 usnic acid 100 µM -0.431122887360133 0.319933260111636 no 2299 0.333189509859335 3385 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1511 0906-3109 28.5 µM -0.432188950925161 0.319550366051704 no 2300 0.33280204457947 3199 2882180 SGTC_1230 0170-0365 3.77 µM -0.432445139465685 0.319458380414307 no 2301 0.332708958364108 3324 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1667 st014849 34.6 µM -0.432649028085416 0.319385181234706 no 2302 0.33263488271631 3201 5348460 SGTC_2241 6772625 37.8075 µM -0.433108876830801 0.319220114238609 no 2303 0.332467837089936 3244 2285411 SGTC_860 0443-0016 25.1 µM -0.433806616716629 0.318969722436107 no 2304 0.332214438166829 3223 5337942 SGTC_751 0833-0568 350 µM -0.434670593452431 0.318659789126311 no 2305 0.331900773115587 3239 6954252 SGTC_1045 1348-1485 165 µM -0.434873436238411 0.318587041957754 no 2306 0.331827148506042 3169 6810614 SGTC_2874 9043904 71.43 µM -0.435348673199179 0.318416631222053 no 2307 0.331654680078908 3210 4463428 SGTC_1292 0kpi-0043 232 µM -0.435817473970263 0.318248566012649 no 2308 0.331484582369112 3214 3333905 SGTC_2049 5262831 67.185 µM -0.438572960553942 0.317261480325722 no 2309 0.330485496523709 3235 763417 SGTC_1522 st012842 45.6 µM -0.442714957779559 0.315780155282066 no 2310 0.328985960962152 3094 3491067 YOR116C RPO31 SGTC_2279 7948423 32.93 µM -0.446552368469142 0.314410396078227 no 2311 0.327599146633556 3356 1247112 SGTC_2292 7671323 168.05 µM -0.448162025794478 0.313836589169319 no 2312 0.32701813327819 3321 937504 SGTC_155 k072-0202 43.6 µM -0.448459158089875 0.313730717292224 no 2313 0.326910927757198 3263 5857737 SGTC_793 0488-0545 106 µM -0.448690341283953 0.313648354496248 no 2314 0.326827526594026 3175 292548 SGTC_1873 rapamycin 2 nM -0.448761616398053 0.313622963443511 no 2315 0.326801815278182 3203 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2447 5741742 33.78 µM -0.449295530072055 0.313432790076625 no 2316 0.32660924093178 3287 1776504 SGTC_3297 9117502 71.43 µM -0.45079243910518 0.312899874348161 no 2317 0.326069575587426 3286 7453720 SGTC_1193 1488-0126 41.5 µM -0.450874020520786 0.312870841704247 no 2318 0.326040174323852 3205 1384710 SGTC_3072 9116419 49.47 µM -0.453512388337272 0.311932543693427 no 2319 0.325089912412641 3237 17170162 SGTC_3301 9125354 19.7965 µM -0.454001358152424 0.311758782259382 no 2320 0.324913924631245 3248 41905162 SGTC_1074 carmofur 3.8 µM -0.454351379550933 0.311634423581255 no 2321 0.324787970517129 3236 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_631 k072-0230 41.5 µM -0.45538675354482 0.311266692601614 no 2322 0.32441551169589 3276 5773147 SGTC_537 1334-0398 209 µM -0.455572368828819 0.311200788014444 no 2323 0.324348758190145 3329 5846986 SGTC_2000 st075254 36.4 µM -0.456850518896327 0.310747132298739 no 2324 0.323889245745751 3279 17234175 SGTC_7 0192-1582 4.227 µM -0.456865393663902 0.310741854466747 no 2325 0.323883899641081 3250 252616 SGTC_1008 4106-0037 6 µM -0.458584181170252 0.310132260569872 no 2326 0.323266399212823 3139 2905394 SGTC_2977 9011197 71.43 µM -0.459606364416344 0.30976997500952 no 2327 0.322899395026877 3371 2704722 SGTC_1812 st052057 4.327 µM -0.46002642883913 0.309621147915223 no 2328 0.322748625254238 3190 3645418 SGTC_1148 3909-7663 27.7 µM -0.460413484249062 0.309484043404078 no 2329 0.322609728883812 3333 4084526 SGTC_3069 9117009 49.47 µM -0.460542603899277 0.309438311956432 no 2330 0.322563399289299 3213 41904981 SGTC_679 0422-0091 41.4 µM -0.460890485318515 0.309315114407334 no 2331 0.322438589203549 3200 627384 YHR062C RPP1 SGTC_3076 9116187 49.47 µM -0.461698772688648 0.309028953021777 no 2332 0.322148675666799 3287 27241210 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.462577126470256 0.308718117076922 no 2333 0.321833753615472 3242 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_842 0271-0008 11.1 µM -0.462591432245281 0.308713055615522 no 2334 0.321828625528587 3345 1221709 SGTC_785 1270-0111 65.3 µM -0.464082499733132 0.308185707206507 no 2335 0.321294319693851 3187 6741994 SGTC_2095 5432005 200 µM -0.46627979252436 0.307409308234909 no 2336 0.320507620550865 3197 783734 SGTC_3314 9135860 59.4275 µM -0.466585241096788 0.307301448167474 no 2337 0.32039832417436 3335 25252478 SGTC_3232 9132874 49.47 µM -0.467849529892438 0.306855179558329 no 2338 0.319946098923523 3255 3784940 SGTC_2348 9022543 33.42 µM -0.468475003378936 0.306634505681489 no 2339 0.319722471262459 3312 3162678 YDL140C RPO21 SGTC_2184 6075246 200 µM -0.468903427328437 0.306483393467644 no 2340 0.319569333195626 3285 2267320 SGTC_782 0083-0095 30.5 µM -0.468913690841202 0.306479773760336 no 2341 0.31956566492987 3240 3591729 An indicator and reagent. SGTC_3179 9107801 49.47 µM -0.469150310687073 0.306396328563177 no 2342 0.319481099903306 3229 4818259 SGTC_728 3030-5151 22.5 µM -0.469404728395263 0.306306618059026 no 2343 0.319390184612181 3240 3125388 SGTC_3351 9150312 21.596 µM -0.470526476576523 0.305911215721676 no 2344 0.318989461291542 3310 4904905 SGTC_2296 7971656 126.45 µM -0.471832626937066 0.305451098803997 no 2345 0.318523130255224 3290 666570 SGTC_1847 st056231 15 µM -0.472060288472987 0.305370932003806 no 2346 0.318441878309356 3217 5393180 SGTC_205 1486-1330 71.903 µM -0.472317303456937 0.305280440145411 no 2347 0.318350160669863 3265 4118834 SGTC_3275 9138069 49.47 µM -0.47336690892765 0.304911010361669 no 2348 0.317975717054132 3313 17617007 SGTC_90 0870-0863 4.608 µM -0.47374004553756 0.304779725290129 no 2349 0.317842646480887 3213 1738164 SGTC_421 streptovitacin 30 mM -0.473990605864616 0.304691581787313 no 2350 0.317753303113287 3371 91467 include heat shock SGTC_1309 pyrazolanthrone 13.4 µM -0.475340619198279 0.304216861801631 no 2351 0.317272105783854 3329 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1624 st003710 6.25 µM -0.475892415411676 0.304022922550073 no 2352 0.317075512957071 3323 24207033 SGTC_2994 9053520 71.4286 µM -0.477003143241445 0.303632703407195 no 2353 0.31667994169003 3341 4647384 SGTC_2594 a-mangostin 100 µM -0.47702291439131 0.303625759463936 no 2354 0.316672902349088 3362 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2989 9073649 71.4286 µM -0.480348328621638 0.302458831324861 no 2355 0.315489864715612 3365 21367202 SGTC_3136 9095672 49.47 µM -0.480951855624016 0.302247262169371 no 2356 0.315275358228234 3259 17217380 SGTC_1375 2910-0797 186 µM -0.482363246211437 0.301752752178388 no 2357 0.314773962766523 3251 742508 SGTC_2887 9044784 58.44 µM -0.483834712841432 0.301237580938969 no 2358 0.314251588678208 3288 6465546 SGTC_594 1487-1584 10.8 µM -0.483965230091586 0.301191905027799 no 2359 0.314205272687266 3242 5013332 SGTC_687 k029-0044 34.9 µM -0.484978333121935 0.300837464913729 no 2360 0.313845857515467 3355 5829338 SGTC_2167 5876490 200 µM -0.487030192750573 0.300120186695837 no 2361 0.313118467316888 3400 686534 SGTC_2268 7933382 153.85 µM -0.488468543626637 0.299617837228684 no 2362 0.312609000771243 3336 935025 YOR257W CDC31 SGTC_2077 5212015 200 µM -0.489230687330228 0.299351810181854 no 2363 0.312339193039576 3255 780900 SGTC_357 1325-0123 420 µM -0.489437446775329 0.299279659061494 no 2364 0.312266015131923 3362 1098503 SGTC_10 0279-0212 42.575 µM -0.489995220178787 0.299085056885626 no 2365 0.312068640579245 3302 39851 YBR002C RER2 SGTC_2305 7443522 69.23 µM -0.491424885913077 0.298586521759242 no 2366 0.311562983278924 3305 5415886 SGTC_2338 7999974 200 µM -0.494927614004532 0.297366694563969 no 2367 0.310325608783177 3297 315925 SGTC_863 0466-0191 129 µM -0.495018959947392 0.297334913762333 no 2368 0.310293368520736 3360 765160 YPR165W RHO1 SGTC_165 k038-0023 64.381 µM -0.497947614189763 0.296316808837268 no 2369 0.30926048297619 3276 46368543 SGTC_2764 methyldopa 94.69 µM -0.499537926568702 0.295764629925505 no 2370 0.308700237547754 3439 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1217 1183-1422 255 µM -0.500534662215469 0.295418790421041 no 2371 0.308349327865787 3384 2849664 SGTC_39 0986-0283 58.349 µM -0.5025719151451 0.294712499719993 no 2372 0.307632639533638 3444 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3117 9124945 49.47 µM -0.502823898127252 0.294625194442406 no 2373 0.30754404497629 3226 17592065 SGTC_1988 st071872 53.4 µM -0.50327289271402 0.294469659557574 no 2374 0.307386211039405 3392 16414116 SGTC_2473 5854593 8.94 µM -0.505111570595634 0.293833124323997 no 2375 0.306740237521985 3216 2872951 SGTC_1780 st038448 24.544 µM -0.506329784562564 0.293411739503148 no 2376 0.306312578661654 3417 728868 YDL195W SEC31 SGTC_2840 9008771 71.43 µM -0.507737461734777 0.292925167608918 no 2377 0.305818736434826 3310 2992978 SGTC_2046 4110841 106 µM -0.508601506229396 0.292626691135977 no 2378 0.305515786488755 3419 44119630 YMR134W ERG29 SGTC_2321 7390090 138.78 µM -0.508641970041604 0.292612716736505 no 2379 0.305501602390734 3297 649046 SGTC_1260 0700-1617 7.75 µM -0.508822194912138 0.292550478855116 no 2380 0.305438430296807 3368 2853078 SGTC_641 4092-0595 30 µM -0.509207653928866 0.292417387176459 no 2381 0.305303339348749 3382 786260 SGTC_1665 st014639 11.4 µM -0.509591843433018 0.292284761853673 no 2382 0.305168719705905 3407 981133 YIL048W NEO1 SGTC_1996 st072960 66.8 µM -0.510249396048477 0.292057834319795 no 2383 0.304938375043691 3419 1719405 SGTC_1736 st036774 51 µM -0.510398017706965 0.29200655496624 no 2384 0.304886322680564 3466 1272247 SGTC_1668 st014914 51.6 µM -0.511856565982119 0.291503530483114 no 2385 0.304375699074872 3394 2839556 SGTC_1052 3253-3998 198 µM -0.512022754751327 0.291446240917365 no 2386 0.304317542167101 3310 5450317 SGTC_2238 6671620 73.2395 µM -0.513548682028259 0.290920460012338 no 2387 0.303783783205922 3321 729941 SGTC_1444 4112-3581 28 µM -0.514961696593487 0.290433980516367 no 2388 0.303289893168358 3381 2877249 SGTC_748 act1.228 77.9 µM -0.517736073318272 0.289479914193087 no 2389 0.302321212951983 3357 4421505 YNR035C ARC35 SGTC_886 0866-0150 153 µM -0.517889772386527 0.289427102461096 no 2390 0.302267589155008 3442 271463 SGTC_1397 3532-0190 20.1 µM -0.51800907717046 0.289386111889373 no 2391 0.30222596806162 3260 5322280 SGTC_1357 1503-1303 39.5 µM -0.518091519675372 0.289357788001874 no 2392 0.302197208377457 3348 292895 SGTC_2004 4023728 41.89 µM -0.520760717614252 0.288441464865577 no 2393 0.301266735606815 3433 360084 YDR527W RBA50 SGTC_544 k015-0020 52.4 µM -0.521147821688021 0.288308687496805 no 2394 0.30113189972238 3352 3008304 SGTC_3001 9076041 71.4286 µM -0.521156568480955 0.288305687664666 no 2395 0.301128853358305 3362 16004211 SGTC_2715 st079500 56.4 µM -0.521571772740129 0.288163304626801 no 2396 0.300984260524133 3326 28246688 SGTC_1001 4048-4355 44.4 µM -0.522497426986715 0.287845996092014 no 2397 0.30066201873548 3357 21824233 SGTC_1540 guanosine 70.6 µM -0.522711169349447 0.287772749994531 no 2398 0.300587632180233 3367 6802 Guanosine is a purine nucleoside SGTC_1805 st050013 60.3 µM -0.523630690726479 0.287457745151211 no 2399 0.300267715424857 3334 4037144 SGTC_2747 doxorubicin 7.63 µM -0.525371436464805 0.286861856515552 no 2400 0.299662502959947 3309 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2862 9027634 71.43 µM -0.525528738287576 0.28680803811785 no 2401 0.29960784040255 3270 5012562 SGTC_180 1486-1293 102.781 µM -0.52572162299892 0.286742052115059 no 2402 0.299540818919517 3478 4140536 SGTC_280 3448-3607 3.04 µM -0.525745646470453 0.286733834171674 no 2403 0.299532471980621 3406 626179 SGTC_2011 4012611 177 µM -0.526266882017788 0.286555557539857 no 2404 0.299351395007018 3310 2049887 SGTC_3025 9087895 49.47 µM -0.526286429570227 0.286548872772149 no 2405 0.299344605162849 3422 17173641 SGTC_204 PMA1.184 62.41 µM -0.527303133533041 0.286201287802266 no 2406 0.298991549288127 3348 2252213 YGL008C PMA1 SGTC_2919 7978188 46.38 µM -0.527637761736077 0.286086930830055 no 2407 0.298875389235902 3454 2980291 SGTC_1372 2752-0194 270 µM -0.530490636317219 0.285112862447484 no 2408 0.297885899740266 3403 823334 SGTC_1765 st044815 90.4 µM -0.530630918251289 0.28506500623374 no 2409 0.297837282981142 3378 645695 SGTC_413 propylparaben 100 µM -0.530675905874448 0.285049659827592 no 2410 0.297821692627669 3331 7175 A pharmaceutical preservative. SGTC_2960 9079389 5.97 µM -0.530868011373566 0.284984132258267 no 2411 0.297755123113645 3430 16457355 SGTC_3326 9140064 16.379 µM -0.532401095643705 0.284461451737628 no 2412 0.297224113250677 3319 1868434 SGTC_76 0433-0009 400.328 µM -0.533505627056072 0.284085163499055 no 2413 0.296841808429913 3397 2841569 SGTC_2736 butenafine 14.65 µM -0.535817472889123 0.283298342817937 no 2414 0.296042352532841 3332 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_345 1362-0200 395 µM -0.536045675775634 0.283220732257788 no 2415 0.295963491657727 3353 1419823 SGTC_126 0417-1624 672.48 µM -0.53685515983783 0.282945513418741 no 2416 0.295683833216317 3497 41912 YDL195W SEC31 SGTC_1916 st067606 49.2 µM -0.536883339021215 0.282935935009585 no 2417 0.295674100133339 3376 19590279 SGTC_3257 9139206 32.98 µM -0.537091863330356 0.282865060181178 no 2418 0.29560208046532 3401 4910041 SGTC_13 0199-0087 65 µM -0.537531726312537 0.282715584173978 no 2419 0.295450188007983 3435 4589825 SGTC_305 1682-2595 20.8 µM -0.538252807247807 0.28247062569129 no 2420 0.295201263718672 3405 226033 SGTC_3012 9080433 71.4286 µM -0.541556909693177 0.281349495923779 no 2421 0.29406189155388 3452 17688859 SGTC_937 3122-0005 46.7 µM -0.543107662111789 0.280824044788296 no 2422 0.293527838724552 3440 759535 SGTC_140 0062-0056 502.533 µM -0.544051993092026 0.280504303828896 no 2423 0.293202847348913 3344 3758964 SGTC_2742 clothiapine 36.27 µM -0.544467304802767 0.280363739274812 no 2424 0.293059970719359 3399 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1369 1866-0067 208 µM -0.545278637064765 0.28008923780812 no 2425 0.29278094726762 3466 3531355 SGTC_2157 5649910 96.377 µM -0.546992600989347 0.279509773771057 no 2426 0.292191907690498 3369 2858091 SGTC_3225 9130819 49.47 µM -0.548170783558683 0.279111786817758 no 2427 0.291787320645028 3456 4547121 SGTC_2506 ethyl hematommate 54.16 µM -0.548382682037879 0.279040237315993 no 2428 0.291714582563424 3404 3940691 An allergen. SGTC_2832 7992762 51.95 µM -0.548557209368952 0.278981313231229 no 2429 0.291654679168522 3224 2985177 SGTC_2925 9010536 32.5 µM -0.549478349826413 0.278670417215493 no 2430 0.291338609167601 3389 2994177 SGTC_1931 st074438 57.1 µM -0.550105254261463 0.278458925922057 no 2431 0.291123591531014 3422 2787313 SGTC_20 0481-0013 4.944 µM -0.550203860606069 0.278425667391462 no 2432 0.291089777965977 3427 182045 SGTC_1358 1509-0022 2.48 µM -0.55146802520233 0.277999454051139 no 2433 0.290656439938569 3430 3258434 SGTC_1745 st081495 74 µM -0.551785735254059 0.277892388126638 no 2434 0.29054758082216 3423 13842402 YBL026W LSM2 SGTC_2839 9003951 25.97 µM -0.552010066853994 0.277816802171087 no 2435 0.290470728081423 3437 2990634 SGTC_2981 9013952 38.96 µM -0.553792517728341 0.277216582816248 no 2436 0.289860424781059 3392 2996344 SGTC_2563 tomatine 8.54 µM -0.553819977781062 0.277207340930582 no 2437 0.289851027286598 3511 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_969 1313-0238 134 µM -0.554605264985715 0.276943110468247 no 2438 0.289582343506133 3361 5212874 SGTC_1767 st044992 70.3 µM -0.556842448706827 0.27619102812509 no 2439 0.288817539265419 3406 9600693 SGTC_2640 pentamidine 10.38 µM -0.557289327094096 0.276040919560734 no 2440 0.288664883306844 3448 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_314 1671-0008 2.74 µM -0.558191240117578 0.275738084776244 no 2441 0.288356900973953 3392 3913060 SGTC_567 1080-0542 68.4 µM -0.558977850608649 0.275474098432975 no 2442 0.288088418322494 3440 5950415 SGTC_1091 telmisartan 47.6 µM -0.559141230308584 0.27541928383099 no 2443 0.288032669035526 3486 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2129 girgensonine 121.053 µM -0.560060738525699 0.27511088493992 no 2444 0.287719004582928 3398 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_805 3852-0218 479 µM -0.560313642143943 0.275026092042032 no 2445 0.287632761911664 3355 6615355 SGTC_579 4491-1009 110 µM -0.561291111973854 0.27469848946849 no 2446 0.287299549815286 3552 1271041 SGTC_3201 9113999 49.47 µM -0.562543573256543 0.27427900395687 no 2447 0.28687286235907 3458 16649224 SGTC_3178 9107506 49.47 µM -0.562802468010666 0.274192332080875 no 2448 0.286784699777727 3483 8897194 SGTC_1774 st048371 48.465 µM -0.563548568989772 0.273942630707802 no 2449 0.286530698557661 3357 4242727 SGTC_3019 9081971 49.47 µM -0.565088728263714 0.273427533612766 no 2450 0.286006707433509 3534 16451803 SGTC_91 0417-1751 58.384 µM -0.56665616021209 0.272903808146445 no 2451 0.285473905662555 3513 6795624 SGTC_2024 5144227 134 µM -0.567369888499025 0.272665495320585 no 2452 0.285231451685531 3453 3475211 SGTC_1615 st002656 86.5 µM -0.570059829055752 0.271768257311255 no 2453 0.284318559904852 3504 1584458 SGTC_599 1935-0052 86.5 µM -0.572410944965797 0.270985240576006 no 2454 0.283521801320292 3405 9557311 SGTC_3125 9127534 49.47 µM -0.572908960727965 0.270819525744624 no 2455 0.283353168536047 3401 1639235 SGTC_2125 5246583 200 µM -0.575693856922963 0.269893784375366 no 2456 0.282411064156348 3539 835267 SGTC_331 k048-0133 24.5 µM -0.578524873796364 0.268954338226532 no 2457 0.281454904523001 3455 6813582 SGTC_1396 3511-0007 98.6 µM -0.57909182734208 0.268766397552376 no 2458 0.281263607124947 3454 X1396 SGTC_2699 st077704 54.6 µM -0.579686258369023 0.268569419175213 no 2459 0.281063105907993 3455 645852 SGTC_262 fenpropimorph 62.5 µM -0.579759915046909 0.268545016396356 no 2460 0.281038266365286 3457 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2376 9072922 81.32 µM -0.579772044694225 0.268540997898145 no 2461 0.281034175936434 3522 17087968 SGTC_1803 st050068 52.4 µM -0.581459831833482 0.267982136410379 no 2462 0.28046529138337 3561 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3212 9128307 49.47 µM -0.581740206926404 0.267889355129278 no 2463 0.280370842336964 3293 27243542 SGTC_210 3551-0445 56.827 µM -0.584858319976719 0.266858605818973 no 2464 0.279321493085588 3537 2865180 YOR207C RET1 SGTC_1020 4335-0961 93.3 µM -0.585111732369415 0.266774923844346 no 2465 0.279236295261302 3347 669075 SGTC_1923 st058458 19.1 µM -0.58690975290587 0.266181561659818 no 2466 0.278632159634806 3553 3534982 SGTC_2239 6685329 187.64 µM -0.587235833630999 0.266074023846848 no 2467 0.278522664599846 3503 805680 SGTC_577 r071-0003 38.6 µM -0.587366740523219 0.26603085839361 no 2468 0.278478713115832 3491 4568517 YMR134W ERG29 SGTC_911 3456-4043 236 µM -0.588919644291175 0.265519072117154 no 2469 0.27795758962008 3484 914281 SGTC_1268 0828-0275 2.46 µM -0.589263052858717 0.265405963364615 no 2470 0.277842412853098 3511 745337 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.591179149511617 0.264775306245432 no 2471 0.277200195825763 3427 4174840 SGTC_119 0121-0043 24.815 µM -0.591326948255378 0.264726691972831 no 2472 0.277150688389235 3576 1092378 SGTC_2249 haloperidol 116.36 µM -0.591800404414641 0.264570992344495 no 2473 0.276992126182345 3510 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1740 st038286 13.222 µM -0.592740467902163 0.264261983523272 no 2474 0.276677427152581 3534 716786 SGTC_1079 idarubicin 2.36 µM -0.593103315848566 0.264142760739052 no 2475 0.276556005752032 3493 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2462 5162487 171.77 µM -0.59482606322147 0.263577083033735 no 2476 0.275979871928721 3492 2259986 SGTC_1864 st057645 30.4 µM -0.595424493089179 0.263380728617513 no 2477 0.27577987865255 3548 688666 SGTC_3108 9121785 49.47 µM -0.59548558392097 0.263360687939925 no 2478 0.275759466306473 3489 17140271 SGTC_3254 9136651 49.47 µM -0.595586292393486 0.263327652505185 no 2479 0.275725818096067 3464 16454030 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.60078578153456 0.261624941947129 no 2480 0.273991337752618 3457 6708784 An antioxidant flavonoid SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.601063027988623 0.261534309186341 no 2481 0.273899003679361 3436 803109 SGTC_563 tetrahydrosecaminediol 614 µM -0.601514297514376 0.2613868221983 no 2482 0.273748745920391 3557 334274 A psychoactive constituent of the cannabis plant. SGTC_2083 5306046 65.942 µM -0.602576268841485 0.261039910098175 no 2483 0.273395305694844 3527 539837 SGTC_2666 tannic acid 100 µM -0.602827395451948 0.260957909677873 no 2484 0.273311759981104 3542 16134267 A thiamine antagonist. SGTC_2368 9071271 200 µM -0.602871720947931 0.260943437440633 no 2485 0.273297014926973 3479 27209959 SGTC_206 4546-0025 72.014 µM -0.604866896095185 0.260292442111763 no 2486 0.272633720211743 3539 6620745 YIL048W NEO1 SGTC_2089 5281248 129.67 µM -0.607333714500461 0.259488715219946 no 2487 0.271814734186402 3543 2737878 SGTC_1530 rhein 70.4 µM -0.607396318503065 0.259468334574703 no 2488 0.271793965538223 3552 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_44 0929-0055 61.211 µM -0.607405725098346 0.259465272342248 no 2489 0.271790845002993 3436 1379590 SGTC_2949 9072542 2.23 µM -0.60772587972 0.25936106001598 no 2490 0.271684647835849 3531 16457352 SGTC_1830 st055982 50.3 µM -0.60800364070122 0.259270664606516 no 2491 0.271592529625673 3518 455313 An antimicrobial agent. SGTC_1802 st050112 57.9 µM -0.609406453366986 0.258814377717149 no 2492 0.27112753072326 3522 4662563 SGTC_1974 st069448 26.9 µM -0.609539049658488 0.258771270192227 no 2493 0.271083598763906 3506 6323587 YNR016C ACC1 SGTC_15 0266-0086 27.098 µM -0.609672131135455 0.258728008668371 no 2494 0.271039509622397 3589 1712902 YIL048W NEO1 SGTC_3291 9121177 71.43 µM -0.610498708275513 0.258459392572896 no 2495 0.270765749410118 3470 17015612 SGTC_2316 5844804 197.44 µM -0.610790144364032 0.258364717874426 no 2496 0.270669259457183 3542 776813 SGTC_1004 4084-0029 199 µM -0.61086010744591 0.258341992637708 no 2497 0.270646098325837 3549 716894 YLR208W SEC13 SGTC_2430 5571206 200 µM -0.611043166198686 0.25828253684342 no 2498 0.270585501793493 3577 1731771 SGTC_2327 6189656 200 µM -0.611912192749611 0.258000381810765 no 2499 0.270297927094502 3539 5349088 SGTC_2737 bleomycin 30.5 nM -0.612651017932005 0.25776062628741 no 2500 0.270053558332583 3547 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3353 9151644 39.2805 µM -0.613812030979383 0.257384100731636 no 2501 0.26966977306386 3536 4909158 SGTC_846 0335-0850 148 µM -0.613916099547998 0.25735036444846 no 2502 0.269635385433516 3523 6819598 SGTC_3299 9121982 43.1275 µM -0.614445910529724 0.257178649347608 no 2503 0.269460352769029 3505 17594604 YPL160W CDC60 SGTC_1609 st001574 46.4 µM -0.614633388415031 0.257117900848148 no 2504 0.269398429695266 3458 3960012 SGTC_1251 0490-5699 265 µM -0.615080873254257 0.256972932406986 no 2505 0.269250656375821 3591 3883818 SGTC_628 1636-0253 16 µM -0.617221163979191 0.256280146358911 no 2506 0.26854442899056 3516 4456143 SGTC_1654 st012436 41.8 µM -0.61913768212267 0.255660620021525 no 2507 0.267912830542983 3525 4323132 SGTC_389 tpck 16.7 µM -0.619382489972304 0.255581540738421 no 2508 0.267832206770193 3525 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1254 0550-0035 264 µM -0.619643200528606 0.255497338519004 no 2509 0.267746359121828 3564 15121435 SGTC_1944 st076371 56.9 µM -0.620021361896723 0.255375228734369 no 2510 0.267621861521778 3447 24208455 SGTC_55 0767-0285 6.563 µM -0.622915196181389 0.254441809044135 no 2511 0.266670125711976 3534 3116166 SGTC_228 caffeine 993.056 µM -0.624360116245883 0.253976413466714 no 2512 0.266195555901822 3554 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3144 9087057 49.47 µM -0.624632360463699 0.253888776121579 no 2513 0.266106187853933 3522 17249618 SGTC_1042 0350-0096 82 µM -0.625636312023744 0.253565734228271 no 2514 0.26577675780917 3551 3122515 SGTC_2406 ethylparaben 405.7 µM -0.626687209806987 0.253227817884545 no 2515 0.265432144731769 3346 8434 A possible steroid mimic. SGTC_2778 tioconazole 65.09 nM -0.627010084803769 0.25312404495331 no 2516 0.265326312291387 3533 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_45 0kpi-0036 14.9 µM -0.627346534878385 0.253015932757704 no 2517 0.26521605298536 3566 2795021 SGTC_2390 9097792 176.6 µM -0.628338857447574 0.2526972092591 no 2518 0.264890990820231 3476 4497149 SGTC_1804 st050076 49.1 µM -0.629557637439542 0.252306039550195 no 2519 0.264492023658846 3582 3895976 SGTC_3052 9092717 49.47 µM -0.630169706698323 0.252109715266296 no 2520 0.264291778426184 3556 25237534 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.630220071810559 0.252093563993048 no 2521 0.264275304360208 3450 88881 An O-methylated flavonoid and antioxidant. SGTC_2792 7535235 81.82 µM -0.630417978048587 0.252030103964606 no 2522 0.26421057571759 3510 1281891 SGTC_2394 5221648 200 µM -0.631179761679488 0.251785911366138 no 2523 0.263961496643782 3599 788586 SGTC_142 0335-0849 62.6745 µM -0.631567940587556 0.251661527224995 no 2524 0.263834620504453 3600 3889043 YPR107C YTH1 SGTC_1049 3226-0134 66 µM -0.631860533068129 0.251567793291518 no 2525 0.263739007311155 3588 5702385 SGTC_769 0302-0231 76 µM -0.632172840548371 0.25146776388185 no 2526 0.263636971164013 3590 571869 YER009W NTF2 SGTC_1664 st014217 9.02 µM -0.633215241202228 0.251134044102589 no 2527 0.263296547055576 3630 3982782 SGTC_1529 apigenin 74 µM -0.633527873648716 0.251034001945807 no 2528 0.263194492257238 3637 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_89 0302-0250 142.109 µM -0.635216560104964 0.250493988264336 no 2529 0.262643592093388 3626 4203518 YLR208W SEC13 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.636516346974853 0.250078757787725 no 2530 0.262219964845908 3458 6708630 An antioxidant. SGTC_195 4234-0266 16.654 µM -0.639075896234001 0.249262151800247 no 2531 0.26138677975969 3556 2303354 SGTC_352 k048-0007 5.11 µM -0.640957470871444 0.248662754270117 no 2532 0.260775157431968 3555 6811911 SGTC_410 α-linolenic acid 100 µM -0.641105891009501 0.24861550599301 no 2533 0.26072694351655 3619 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1806 st050005 60.3 µM -0.641535066770493 0.248478908484618 no 2534 0.260587552644172 3540 5194765 SGTC_2026 5148700 152 µM -0.642703078678848 0.248107357780352 no 2535 0.260208391483611 3571 79838 SGTC_1447 4239-0816 81.9 µM -0.644053912335664 0.247678020369536 no 2536 0.259770237380359 3520 1341554 SGTC_177 1327-0068 8.361 µM -0.645181061474378 0.247320080823083 no 2537 0.259404928800232 3580 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1050 3232-1156 69.3 µM -0.645253349007993 0.247297134501366 no 2538 0.259381509498699 3527 700529 SGTC_2662 daunorubicin 22.37 µM -0.645387070137942 0.247254690237056 no 2539 0.259338190171479 3514 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_233 rapamycin 362 pM -0.648144882529859 0.246380205475664 no 2540 0.258445623510362 3606 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2461 5755302 26.15 µM -0.648206181294958 0.246360786877407 no 2541 0.258425802244314 3605 2788904 SGTC_1054 3429-0080 167 µM -0.64834452512481 0.246316964486703 no 2542 0.258381070961027 3611 1162877 SGTC_1730 st033808 45.1 µM -0.648545546895423 0.24625329540801 no 2543 0.258316080909993 3588 1045166 SGTC_853 0419-0306 21 µM -0.64982302552764 0.245848889367896 no 2544 0.257903271956163 3517 762713 SGTC_1559 coumarin 343 70.1 µM -0.649892536071056 0.245826894937884 no 2545 0.257880819896736 3629 108770 A hepatotoxic, DNA x-linker. SGTC_1327 1436-0082 2.18 µM -0.651017317294076 0.245471140089924 no 2546 0.257517654104521 3562 15992205 SGTC_2879 9041815 71.43 µM -0.651735840043271 0.24524402481795 no 2547 0.257285798890842 3550 4942971 SGTC_264 promethazine 12.5 mM -0.652084673712462 0.245133803989136 no 2548 0.257173275267103 3652 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1468 k284-1086 134 µM -0.652447016615335 0.245019342867653 no 2549 0.257056421055139 3616 15996457 SGTC_275 trichlorophene 5.69 µM -0.65289478601672 0.244877935951144 no 2550 0.256912055280572 3614 62616 SGTC_2435 5706476 10.6 µM -0.65350834704368 0.244684242888468 no 2551 0.256714304995703 3607 5725375 SGTC_2978 9011784 42.97 µM -0.654730141897539 0.244298784314192 no 2552 0.256320757529409 3650 2994934 SGTC_796 1234-0020 70.7 µM -0.655870076777338 0.24393944672992 no 2553 0.255953861416817 3574 46495034 SGTC_217 ketoconazole 989 nM -0.656813893527835 0.243642146697267 no 2554 0.255650294802943 3562 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1901 st060216 58.6 µM -0.659184693393274 0.242896214158848 no 2555 0.254888587418471 3618 688792 SGTC_2834 9001755 58.44 µM -0.660551215785152 0.242466822764628 no 2556 0.254450081654859 3534 2989575 SGTC_535 2293-4129 48.2 µM -0.662008639771964 0.242009321592178 no 2557 0.253982842325349 3631 396118 YIL048W NEO1 SGTC_1986 st071812 45 µM -0.663821248065501 0.241440978081503 no 2558 0.25340236228806 3597 11838594 SGTC_505 gw-5074 63.9 µM -0.663958900839131 0.241397846679967 no 2559 0.253358308081976 3614 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2502 avocadyne acetate 18.59 µM -0.665370856510247 0.240955673622112 no 2560 0.252906660250105 3599 3952079 SGTC_817 1391-0715 46 µM -0.666157947504491 0.24070937676692 no 2561 0.252655074421957 3576 1353946 SGTC_1630 st005209 31.3 µM -0.666387034005644 0.240637716671714 no 2562 0.25258187396847 3628 3367314 SGTC_2801 7907800 81.82 µM -0.668364058672813 0.240019770326383 no 2563 0.251950615991868 3643 6620925 SGTC_2976 9009005 19.48 µM -0.670797815694025 0.23926025565161 no 2564 0.251174669583402 3651 2993148 SGTC_3214 9129694 49.47 µM -0.671456698804287 0.239054860814072 no 2565 0.25096481775482 3597 17158655 SGTC_81 0411-0046 9.971 µM -0.673910008139466 0.238290934487668 no 2566 0.250184264457596 3529 12925265 SGTC_2661 dactinomycin 12.96 µM -0.674459902906983 0.238119888558498 no 2567 0.250009484864705 3645 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3148 9097893 49.47 µM -0.674693229075685 0.238047332296844 no 2568 0.249935343616438 3573 17174100 SGTC_1426 4048-4480 71.7 µM -0.675024244588052 0.237944418865997 no 2569 0.249830180824766 3623 14224343 SGTC_2104 5389443 200 µM -0.677025346132463 0.237322791881053 no 2570 0.249194936496155 3675 2244536 SGTC_25 0118-0223 35.662 µM -0.679380550242037 0.236592309562911 no 2571 0.248448385150894 3670 5333628 SGTC_166 k072-0058 166.424 µM -0.67955875905035 0.236537087297736 no 2572 0.248391945163509 3655 5846229 SGTC_3043 9092303 49.47 µM -0.680426242294664 0.236268378171142 no 2573 0.248117304724902 3604 25236084 SGTC_772 k072-0172 35.3 µM -0.6809835410166 0.236095839636789 no 2574 0.247940952497646 3585 5861980 SGTC_1231 0242-0792 125 µM -0.681150220643455 0.236044249456674 no 2575 0.247888221209309 3639 3707635 SGTC_2971 9092186 9.93 µM -0.681440373310153 0.235954457089739 no 2576 0.247796441885133 3608 25236400 SGTC_3055 9094636 49.47 µM -0.68437084548922 0.235048631760072 no 2577 0.246870510547505 3681 25236176 SGTC_1256 0570-0116 285 µM -0.68637973380461 0.234428784666296 no 2578 0.246236840426642 3649 410638 SGTC_889 0919-1524 82.7 µM -0.688608899775737 0.233742030345073 no 2579 0.245534709472973 3652 3905452 SGTC_1257 0669-0121 16 µM -0.688857182608185 0.233665609244569 no 2580 0.245456573276379 3684 4307855 SGTC_2775 cyproheptadine 69.59 µM -0.689234735854603 0.23354942544852 no 2581 0.245337780463724 3659 2913 A selective serotonin reuptake inhibitor. SGTC_294 k038-0071 157 µM -0.689692512975601 0.233408597482798 no 2582 0.245193787584602 3660 24152826 SGTC_1743 st037606 46.3785 µM -0.68986689992553 0.233354962461384 no 2583 0.245138946472983 3684 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2544 sphondin 68.51 µM -0.690549554215054 0.23314506886798 no 2584 0.2449243291981 3680 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1283 0922-0125 16.4 µM -0.693304684418618 0.232299023532377 no 2585 0.244059181956449 3677 3360884 SGTC_1386 3228-0095 33.8 µM -0.696184531317564 0.231416509053561 no 2586 0.243156636853457 3648 870181 SGTC_3242 9133940 49.47 µM -0.696247740816185 0.231397159813821 no 2587 0.243136847232678 3702 17248444 SGTC_3064 1327-0027 10 µM -0.696399263694744 0.231350780387389 no 2588 0.243089412017764 3559 16000455 YPR107C YTH1 SGTC_2851 9015922 71.43 µM -0.696615986219849 0.231284453103861 no 2589 0.243021574331906 3662 2996893 SGTC_884 0851-0618 334 µM -0.696639906904838 0.231277132899496 no 2590 0.243014087394789 3674 9642473 SGTC_2658 polymyxin b sulfate 77.05 µM -0.697018937367311 0.231161159305141 no 2591 0.242895471272023 3658 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2861 9024595 19.48 µM -0.697059117013873 0.231148867266987 no 2592 0.242882899043108 3604 16482810 SGTC_1849 st056239 19.2 µM -0.697661340765961 0.230964674477533 no 2593 0.242694505164137 3646 5393181 SGTC_3271 9137798 49.47 µM -0.697696431910598 0.230953944223247 no 2594 0.242683530028017 3610 6498326 SGTC_2391 6285546 200 µM -0.698133903252857 0.230820196552688 no 2595 0.242546728678179 3661 846083 SGTC_2439 5492030 7.2 µM -0.698534247752293 0.230697837549309 no 2596 0.242421573843537 3652 5722370 SGTC_3251 9135047 49.47 µM -0.698874778610134 0.23059378817111 no 2597 0.242315145363297 3656 17682963 SGTC_2148 5546263 113.568 µM -0.698937936294627 0.23057449319148 no 2598 0.242295409036329 3674 792097 SGTC_881 0833-0569 170 µM -0.700271633331484 0.230167253016554 no 2599 0.241878841711259 3674 5418700 SGTC_2365 9042475 200 µM -0.700858065591842 0.229988315215319 no 2600 0.241695798350528 3708 6464479 SGTC_1279 0874-0590 65.2 µM -0.701298547771888 0.229853962311245 no 2601 0.241558359917468 3700 3523074 SGTC_3190 9110366 49.47 µM -0.701339016665445 0.229841620966553 no 2602 0.241545735017292 3611 17123768 SGTC_3306 9127676 59.7925 µM -0.701616618812782 0.229756973753926 no 2603 0.241459142373721 3683 41905287 SGTC_2620 irigenin 100 µM -0.703157921601526 0.229287313129366 no 2604 0.240978669495231 3699 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_626 0214-0009 33 µM -0.704661801057071 0.228829575301045 no 2605 0.240510364293006 3712 3437874 SGTC_46 0329-0187a 2.197 µM -0.706306583898024 0.228329538313527 no 2606 0.239998749962654 3703 46494817 SGTC_1166 k206-0078 225 µM -0.708803808631401 0.227571522380572 no 2607 0.239223116980823 3704 5404595 SGTC_274 sirtinol 40.1 µM -0.708989639616616 0.227515171326151 no 2608 0.239165453055768 3694 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2519 cryptotanshinone 88.04 µM -0.70916267505043 0.227462707437785 no 2609 0.239111766459791 3656 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_763 3453-1109 128 µM -0.710617474419616 0.22702188566853 no 2610 0.238660655769029 3697 1560353 SGTC_1086 cerivastatin 2.18 µM -0.711833551272399 0.226653769634125 no 2611 0.238283926868093 3647 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_465 cgp-37157 41 µM -0.711997151743013 0.226604272206343 no 2612 0.238233269887916 3609 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1636 st007707 68.9 µM -0.712901839201421 0.226330668619407 no 2613 0.237953250500252 3706 403051 SGTC_367 0335-0881 7.1 µM -0.713229265911984 0.226231691343187 no 2614 0.237851949684002 3670 23828853 SGTC_1392 3455-1037 33.9 µM -0.713661327978213 0.226101121453283 no 2615 0.237718312490497 3701 981132 SGTC_2488 5268135 45.7 µM -0.714806060060316 0.225755387461314 no 2616 0.237364445024076 3732 1270356 YLR208W SEC13 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.714879253781206 0.225733291541685 no 2617 0.237341828719407 3716 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1165 k072-0275 30.3 µM -0.714924185331912 0.225719728088931 no 2618 0.237327945797169 3706 6153523 YGL055W OLE1 SGTC_1685 st024049 53.0905 µM -0.715065720889806 0.22567700587227 no 2619 0.237284217144578 3698 1941139 SGTC_2927 9011802 47.9 µM -0.716033726073583 0.225384938172565 no 2620 0.2369852621068 3698 43912568 SGTC_3081 9117243 49.47 µM -0.71637652142624 0.225281560877614 no 2621 0.236879444152607 3717 45595589 SGTC_1433 4060-0023 7.6 µM -0.716839582722141 0.22514195745347 no 2622 0.236736542400465 3716 3840627 SGTC_1445 4239-0156 97.7 µM -0.717041045658214 0.225081235839139 no 2623 0.236674385292252 3758 4008346 SGTC_3215 9129942 49.47 µM -0.71720345078235 0.225032293138162 no 2624 0.236624285178098 3636 17682944 SGTC_1866 st057638 64 µM -0.71724876399251 0.225018638543621 no 2625 0.236610307614735 3689 688802 SGTC_1617 st002906 78 µM -0.717473853171617 0.224950817568059 no 2626 0.236540882095134 3723 5150859 SGTC_3261 9137475 49.47 µM -0.717539066065048 0.224931170622839 no 2627 0.236520770210648 3577 17027690 SGTC_2067 5224629 34.075 µM -0.718331666554226 0.224692458515835 no 2628 0.236276404685809 3683 2835000 SGTC_2266 7929956 200 µM -0.718584374222282 0.224616379294461 no 2629 0.236198521984891 3696 2967153 SGTC_2606 farnesol 9.78 µM -0.718818004250187 0.224546056517266 no 2630 0.236126531457035 3733 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2628 lathosterol 100 µM -0.719525558807883 0.224333158393368 no 2631 0.235908580042042 3755 6710616 SGTC_2707 st078556 66.6 µM -0.720081288362822 0.224166023704072 no 2632 0.235737473786627 3691 17250899 SGTC_2366 9070441 60.58 µM -0.720809900040614 0.223947002192684 no 2633 0.235513241739302 3722 6837235 SGTC_2329 6138490 200 µM -0.720840895761724 0.223937687540307 no 2634 0.235503705339777 3753 720019 SGTC_1590 st077108 57.8 µM -0.721419068788695 0.223763978729339 no 2635 0.23532585891194 3678 5489485 SGTC_2298 7976326 193.81 µM -0.72235692374335 0.223482368485427 no 2636 0.235037531807724 3599 2235818 SGTC_685 1278-0033 54.9 µM -0.72279845591344 0.223349859200594 no 2637 0.234901858060423 3749 3590572 SGTC_2309 7664088 163.95 µM -0.724314672565377 0.222895164297203 no 2638 0.234436285557876 3707 704922 SGTC_722 3534-0461 190 µM -0.724537688405929 0.222828329078834 no 2639 0.234367848967876 3702 658262 SGTC_3203 9113543 49.47 µM -0.726938966482319 0.222109418120022 no 2640 0.233631672615274 3775 17018012 SGTC_676 falcarinol 140 µM -0.726952013300079 0.222105515694574 no 2641 0.233627676267656 3746 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_506 n9-isopropylolomoucine 153 µM -0.727518548795589 0.221936097370641 no 2642 0.233454178346143 3709 6610355 SGTC_1152 3909-8331 15.9 µM -0.727538291754427 0.221930194713168 no 2643 0.233448133478558 3701 16001939 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.728123138456726 0.221755380648354 no 2644 0.233269105436931 3739 688664 SGTC_716 1683-5115 658 µM -0.729383635746374 0.221378878318371 no 2645 0.232883512485706 3740 723597 SGTC_2311 7694451 200 µM -0.729852442192916 0.22123894219533 no 2646 0.232740192440129 3694 2163142 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.732115994507501 0.220563996744327 no 2647 0.232048886080448 3713 2333 A French combination drug. SGTC_2206 7254556 146.969 µM -0.735177248291881 0.219653072265261 no 2648 0.231115776682038 3729 4398905 SGTC_1325 1431-0015 227 µM -0.735555443014452 0.219540684569565 no 2649 0.231000643583817 3688 1103340 SGTC_2466 5983409 37.09 µM -0.735979253293937 0.219414780605334 no 2650 0.230871661879267 3748 2879657 SGTC_117 lucigenin 22.078 µM -0.736021735548713 0.219402162424911 no 2651 0.230858735119583 3719 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2902 5787006 60.46 µM -0.738526198480724 0.218659018046885 no 2652 0.230097376504755 3706 591003 SGTC_3034 9090421 49.47 µM -0.738587646245219 0.218640803001517 no 2653 0.230078714012291 3658 17173761 SGTC_381 3461-2219 42.7 µM -0.739125792133289 0.218481317001628 no 2654 0.229915308236985 3713 2883159 SGTC_1821 st053465 65.6 µM -0.739594737313905 0.218342394104699 no 2655 0.229772967955696 3718 675086 SGTC_439 amiodarone 34.4 µM -0.739698951418331 0.218311528058035 no 2656 0.229741342251346 3658 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_574 1315-0397 40 µM -0.740647322535095 0.218030755839011 no 2657 0.229453653488121 3755 6794277 SGTC_2451 5856223 45.7 µM -0.740748119136843 0.218000926509878 no 2658 0.229423088671861 3721 2179896 SGTC_3305 9127027 53.8275 µM -0.741052066486799 0.217910991835116 no 2659 0.2293309357412 3684 41905295 SGTC_1680 diphenhydramine 100 µM -0.742907451768376 0.217362467878208 no 2660 0.228768856930127 3772 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2819 7996655 46.38 µM -0.742933028416532 0.217354912002773 no 2661 0.22876111403257 3670 6456960 SGTC_179 1273-0063 6.77 µM -0.745391250042425 0.216629410145092 no 2662 0.228017615969381 3746 3108139 SGTC_462 ag-879 158 µM -0.747263388893209 0.216077821411487 no 2663 0.227452293678461 3749 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1902 st060212 70.5 µM -0.748514432657569 0.215709679950393 no 2664 0.227074961458301 3763 688944 SGTC_114 0364-0001 490.298 µM -0.748666125941094 0.215665066285203 no 2665 0.227029232654754 3798 4003655 SGTC_975 1335-0046 28.5 µM -0.749329640387851 0.215469986640596 no 2666 0.226829273489626 3760 16486740 SGTC_211 3455-0679 143.504 µM -0.750905358138745 0.215007120810796 no 2667 0.22635480773094 3762 748649 SGTC_927 2425-1185 123 µM -0.751336581899345 0.214880549876821 no 2668 0.226225059325936 3733 730375 SGTC_197 4544-0043 41.561 µM -0.75163950129826 0.21479166417041 no 2669 0.22613394080502 3746 896523 SGTC_932 2857-0803 154 µM -0.754134021498095 0.214060509250585 no 2670 0.225384375232731 3868 674898 SGTC_2776 terbinafine 19.92 µM -0.755627449731136 0.213623472899162 no 2671 0.224936296684485 3780 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_358 0075-0058 9.45 µM -0.756597392821639 0.213339907738372 no 2672 0.224645551899913 3715 1069125 SGTC_3194 9111903 49.47 µM -0.757512515271951 0.213072570823021 no 2673 0.224371435390738 3754 17087251 SGTC_3328 9140624 29.0385 µM -0.757525508561733 0.213068776469761 no 2674 0.224367544737802 3763 4904392 SGTC_2572 astragaloside iv 100 µM -0.758209082657573 0.212869211979386 no 2675 0.224162912358743 3797 45006101 An anti-inflammatory agent. SGTC_1106 tegaserod maleate 11.7 µM -0.758570633395213 0.212763703993617 no 2676 0.224054722648666 3803 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3176 9106582 49.47 µM -0.759157337200147 0.212592556667442 no 2677 0.223879221728176 3660 17018027 SGTC_3159 9100096 49.47 µM -0.760393638298257 0.212232178698058 no 2678 0.223509662411709 3738 25236875 SGTC_449 xestospongin c 11.1929 µM -0.760425258029988 0.212222966329168 no 2679 0.22350021508749 3782 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2881 9058953 51.95 µM -0.761146649008967 0.212012853486727 no 2680 0.223284740045666 3748 17122249 SGTC_404 fumagillin 50 µM -0.761875407263654 0.211800718426672 no 2681 0.223067184543728 3763 12015870 A methionine aminopeptidase binder. SGTC_2986 9022445 71.43 µM -0.762412029022957 0.211644592022949 no 2682 0.222907064561088 3694 6459286 SGTC_3281 9140613 49.47 µM -0.762508093734607 0.211616649767848 no 2683 0.222878407185774 3752 16013766 SGTC_1877 wortmannin 25 µM -0.763572910648444 0.211307072101876 no 2684 0.222560898811217 3778 312145 A covalent inhibitor of PI 3-kinase. SGTC_2207 7258803 200 µM -0.765392434462474 0.210778690498183 no 2685 0.222018948328836 3726 3666799 SGTC_667 1498-1044 59 µM -0.766339509053946 0.210503971198668 no 2686 0.221737157807107 3790 6739982 SGTC_1612 st002233 45.4 µM -0.769366989991583 0.209627196203857 no 2687 0.220837739541612 3796 1035021 SGTC_3168 9103419 49.47 µM -0.770343010573443 0.209344993781407 no 2688 0.220548224641518 3715 16649256 SGTC_2176 5809774 33.9695 µM -0.770555169787375 0.209283680567056 no 2689 0.220485321093609 3785 2870539 SGTC_235 0330-0087 5 mM -0.770905476634131 0.209182466343883 no 2690 0.220381480359289 3826 46494818 YHR062C RPP1 SGTC_1783 st039459 87.517 µM -0.772495189422043 0.208723512590855 no 2691 0.21991059749629 3902 729761 SGTC_1836 st055642 81 µM -0.772786095181545 0.208639591708201 no 2692 0.219824491930857 3817 8571 SGTC_1721 st082152 9.2685 µM -0.772991901440405 0.20858023245843 no 2693 0.219763586764808 3728 5296051 SGTC_2536 dehydroabietamide 32.04 µM -0.778223522131789 0.207074659074257 no 2694 0.218218626077636 3820 3983547 SGTC_159 3970-0959 50 µM -0.779918140618373 0.206588358080898 no 2695 0.2177195299826 3875 6615653 SGTC_991 3996-0057 64.7 µM -0.780155548366758 0.206520283753963 no 2696 0.217649661696204 3846 715343 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.781368610669404 0.206172657585005 no 2697 0.217292863622984 3805 2724 A muscle relaxant with antifungal properties. SGTC_3039 9090270 49.47 µM -0.781665061389999 0.206087756746517 no 2698 0.217205719948816 3776 17173750 SGTC_2998 9066762 71.4286 µM -0.782490324779808 0.205851517893552 no 2699 0.216963234599704 3813 4945196 SGTC_581 0958-0271 211 µM -0.783328956968763 0.205611616770063 no 2700 0.216716981486919 3824 4591145 SGTC_3336 9143619 71.43 µM -0.783491130600021 0.205565244151953 no 2701 0.216669380029578 3812 45595730 SGTC_1850 st056238 17 µM -0.784184033783519 0.205367182417023 no 2702 0.216466066134789 3805 5393177 SGTC_2918 7977171 22.06 µM -0.785607671858958 0.204960600853375 no 2703 0.216048684254146 3738 2236483 SGTC_2657 nystatin 74.44 µM -0.787302523256905 0.20447718706427 no 2704 0.215552396476153 3841 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1663 st014140 55.4 µM -0.788822732425232 0.204044163423672 no 2705 0.215107810573667 3879 4207120 SGTC_2935 9038016 29.96 µM -0.789142360407673 0.203953188618756 no 2706 0.215014402993453 3821 6463195 SGTC_3226 9131256 49.47 µM -0.790758957195937 0.203493431657581 no 2707 0.214542332240461 3694 17178073 SGTC_2744 captopril 92.04 µM -0.794677012872259 0.202381712237429 no 2708 0.213400703620367 3767 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1659 st012954 42.1 µM -0.795304520639455 0.202203999571145 no 2709 0.213218192272702 3829 24207262 SGTC_2753 fluvastatin 17.09 µM -0.795360512666009 0.202188146947183 no 2710 0.213201911352892 3867 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_706 4262-0057 46.9 µM -0.796241729792047 0.201938752164947 no 2711 0.212945773498747 3802 883298 SGTC_730 1436-0052 41.2 µM -0.796520392438752 0.201859925706873 no 2712 0.21286481376094 3839 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_988 1497-1057 103 µM -0.797978404915819 0.20144779212202 no 2713 0.212441511028387 3786 3533044 SGTC_1940 st075990 51.1 µM -0.798171383941315 0.201393280925248 no 2714 0.212385520574803 3889 1084979 SGTC_755 1995-0008 37.3 µM -0.79830935064431 0.201354314596716 no 2715 0.212345496545837 3806 689533 SGTC_3342 9147791 14.508 µM -0.798340105555085 0.201345629015761 no 2716 0.212336575171909 3766 1838168 SGTC_2226 7298446 200 µM -0.798849151932673 0.201201900418353 no 2717 0.212188942993418 3801 3283010 SGTC_3142 9086498 49.47 µM -0.799086525951686 0.201134899203553 no 2718 0.212120120977085 3790 25236367 SGTC_1824 st053723 68.6 µM -0.79908796711049 0.20113449246279 no 2719 0.212119703180762 3833 675225 SGTC_2823 7987624 58.44 µM -0.799656367603781 0.200974110265824 no 2720 0.211954959668216 3815 2239440 SGTC_1510 1123-0200 71.5 µM -0.800345659658658 0.200779719782003 no 2721 0.211755277745879 3873 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1448 4255-0083 152 µM -0.800850775670152 0.200637341321385 no 2722 0.211609019942878 3901 5399660 SGTC_2476 5806916 10.51 µM -0.801312036584262 0.200507377385216 no 2723 0.211475512181863 3743 2870194 SGTC_1334 1486-0610 236 µM -0.802570740065908 0.200152984965324 no 2724 0.211111442990607 3911 3742339 SGTC_2407 paclitaxel 400 µM -0.802734527956756 0.200106897602607 no 2725 0.211064095771696 4015 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2786 7743617 45.45 µM -0.803305431218419 0.199946304186869 no 2726 0.210899109759735 3794 583674 SGTC_2341 7987486 176.74 µM -0.804241088753959 0.199683274110413 no 2727 0.210628876568945 3856 1258686 SGTC_2533 agelasine 13.65 µM -0.804478617619528 0.199616533644545 no 2728 0.210560306698316 3872 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2060 5238662 140 µM -0.804528039069323 0.199602648974922 no 2729 0.210546041352874 3827 790130 SGTC_125 0133-0007 11.75 µM -0.80556030262195 0.199312773380346 no 2730 0.210248211402723 3914 26541 SGTC_876 0720-0963 56.8 µM -0.809327817645308 0.198256949717121 no 2731 0.209163304754303 3855 765861 SGTC_1952 st077036 64.1 µM -0.809651531109318 0.198166388712044 no 2732 0.209070241124281 3840 2937007 SGTC_2717 st081029 62.2815 µM -0.811103630828109 0.197760461481451 no 2733 0.208653080476266 3841 5292846 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.811136737264834 0.197751212604381 no 2734 0.208643575350412 3827 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.812300034839866 0.197426390533671 no 2735 0.208309745288543 3914 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1757 st041620 31.8375 µM -0.814125938558387 0.196917203203173 no 2736 0.20778640386395 3933 5289815 SGTC_951 1171-0579 82.7 µM -0.814649033638426 0.196771475017131 no 2737 0.207636617323166 3821 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3045 9092950 49.47 µM -0.814948227351971 0.196688152508422 no 2738 0.207550972884099 3810 44120432 SGTC_794 k038-0031 316 µM -0.81499200431879 0.196675962845893 no 2739 0.207538443443422 3849 6624242 SGTC_672 1441-0018 53.7 µM -0.815602994807696 0.196505880783082 no 2740 0.207363618028351 3848 251141 SGTC_2152 5568786 200 µM -0.815709050330043 0.196476367076715 no 2741 0.207333280762716 3823 5399883 SGTC_764 1951-2361 146 µM -0.815861871830869 0.196433843804474 no 2742 0.207289570667542 3828 5438930 SGTC_2330 7979373 200 µM -0.816929186020162 0.196137014351689 no 2743 0.206984448791754 3809 1863007 SGTC_3131 9127911 49.47 µM -0.818312396720807 0.195752736251773 no 2744 0.206589414635923 3877 45595681 SGTC_934 2950-0684 338 µM -0.820786096978726 0.195066643086978 no 2745 0.205884059589618 3924 1121253 SGTC_2619 obliquin 87.91 µM -0.821892330356681 0.194760297322036 no 2746 0.205569089220257 3820 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2524 avocatin b 10.57 µM -0.821951846540511 0.194743823990935 no 2747 0.205552151691784 3833 6710748 SGTC_3294 9122953 26.2835 µM -0.823977676832041 0.194183605213429 no 2748 0.204976121066526 3863 16459826 SGTC_1550 gossypolone 36.6 µM -0.82422560977896 0.194115109846849 no 2749 0.204905689042884 3865 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.824619811058701 0.194006235866463 no 2750 0.204793735196206 3885 551469 SGTC_1761 st044296 37 µM -0.825891054394496 0.193655386233647 no 2751 0.204432947788769 3868 1826700 SGTC_2181 6316240 54.2555 µM -0.826008015626262 0.193623125625992 no 2752 0.204399772420635 3889 12779990 SGTC_261 5-fluorouridine 15.376 µM -0.826070237523895 0.193605964725888 no 2753 0.204382124849923 3869 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2788 5282734 71.43 µM -0.828067172467212 0.193055699531987 no 2754 0.203816229680178 3938 743706 SGTC_2088 5278280 127.392 µM -0.828539067303705 0.192925806227841 no 2755 0.203682639789269 3933 791502 SGTC_2525 harmine 47.85 µM -0.829263829650962 0.19272641283935 no 2756 0.203477566697965 3886 5280953 A monoamine oxidase inhibitor SGTC_2045 5106652 78.05 µM -0.831056123893842 0.192233865824507 no 2757 0.202970962304611 3854 673349 SGTC_2601 securinine 100 µM -0.831987325693772 0.191978263040918 no 2758 0.202708049279066 3835 442872 A GABA receptor antagonist. SGTC_1184 1269-1718 139 µM -0.832138862310254 0.191936687897907 no 2759 0.202665284097401 3951 5403821 SGTC_1134 3477-0009 42.5 µM -0.832876342145352 0.19173443376987 no 2760 0.202457236736265 3969 3973534 SGTC_1673 st016611 27.3 µM -0.834127018670193 0.191391733724339 no 2761 0.20210470564341 3930 5226799 SGTC_2999 9069765 71.4286 µM -0.834268711035605 0.191352932039443 no 2762 0.202064789665429 3903 2097066 SGTC_987 1497-1013 404 µM -0.834692412999104 0.191236932323223 no 2763 0.201945457268335 3851 1676435 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.83593577881346 0.190896776697018 no 2764 0.201595516475903 3966 4213774 SGTC_1741 st038134 10.228 µM -0.836312642450051 0.190793749021117 no 2765 0.201489521358314 3944 1272587 SGTC_251 melphalan 456.522 µM -0.836586270778457 0.190718965388376 no 2766 0.201412582709239 3926 460612 A DNA alkylator. SGTC_1030 k029-0042 36.7 µM -0.837885552604922 0.190364112435792 no 2767 0.201047491792521 3879 6080581 SGTC_998 3996-0085 177 µM -0.83885263634444 0.190100251086621 no 2768 0.200776004543086 3913 715391 SGTC_2629 bisabolol 100 µM -0.839060149135762 0.190043662121641 no 2769 0.200717778627856 3916 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1022 4477-0945 21.3 µM -0.839293681658999 0.189979989930845 no 2770 0.200652263971965 3836 4648966 SGTC_289 k017-0060 526 µM -0.839700294669377 0.189869158977177 no 2771 0.200538224370784 3867 5512909 SGTC_50 0929-0078 56.389 µM -0.844061456415012 0.188682933558835 no 2772 0.199317532251248 3776 1377751 SGTC_3021 9087658 49.47 µM -0.846860573255357 0.187923993045079 no 2773 0.198536420331947 3840 25237042 SGTC_2015 5119600 184 µM -0.847490870985614 0.187753357178209 no 2774 0.198360786661931 3940 2828786 SGTC_3101 9120531 49.47 µM -0.848581365437495 0.187458361742217 no 2775 0.19805713982 3904 24824904 SGTC_1115 galangin 695.678 nM -0.849546563169951 0.187197500110236 no 2776 0.197788615997967 3926 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_291 SEC14.278 35.5 µM -0.849922027201231 0.187096085040801 no 2777 0.197684219100558 3909 1068044 SGTC_2211 7117706 200 µM -0.851934249180364 0.186553151206319 no 2778 0.197125293190179 3823 822771 SGTC_1482 3346-2049 8.48 µM -0.853537110771083 0.186121369072359 no 2779 0.196680758465524 3914 3826804 SGTC_1089 terbinafine 2.25 µM -0.853806927979977 0.186048746121152 no 2780 0.196605987605794 3915 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.855522612553848 0.185587370224565 no 2781 0.19613094573587 3928 6728940 SGTC_968 1309-0633 340 µM -0.855786204048907 0.185516549093139 no 2782 0.196058023780091 3940 3761976 SGTC_3164 9100705 49.47 µM -0.858602352995765 0.184760960149489 no 2783 0.195279969747398 3945 17174235 SGTC_2598 perillyl alcohol 100 µM -0.859291416793129 0.184576372087866 no 2784 0.195089879214628 3945 10819 An apoptosis inducer. SGTC_1172 0370-0043 85 µM -0.859983743632181 0.184391025458063 no 2785 0.194899001834732 3966 376585 SGTC_2711 st079103 59.1 µM -0.861626432351037 0.183951715723871 no 2786 0.194446560377267 3890 54693780 SGTC_3303 9125618 40.5795 µM -0.862629075889131 0.183683895994667 no 2787 0.194170719366194 3956 22695467 SGTC_2856 9022925 19.48 µM -0.862854577900777 0.18362369482084 no 2788 0.194108713511195 3969 4944862 SGTC_127 0180-0333 59.125 µM -0.864282137288448 0.183242871584954 no 2789 0.193716460199529 3815 771601 SGTC_1644 st010134 20.9 µM -0.866152458583361 0.182744680856879 no 2790 0.193203280305469 3890 3818134 SGTC_297 0986-0032 24 µM -0.867535603914402 0.182376801856314 no 2791 0.192824306317359 3889 2847425 SGTC_1406 3909-7906 11.9 µM -0.869530121194367 0.181847129885965 no 2792 0.192278620112299 3937 X1406 SGTC_2369 9071472 200 µM -0.870121984506977 0.181690137613652 no 2793 0.192116872285215 4015 17296037 SGTC_64 000l-0018 272.079 µM -0.872837467324619 0.180970940955142 no 2794 0.191375837189733 3874 6811119 SGTC_1513 0337-0559 19 µM -0.873163094284536 0.180884818477458 no 2795 0.191287093781512 3909 775073 SGTC_116 0155-0182 31.788 µM -0.873338277729164 0.180838496234237 no 2796 0.191239361316906 3862 771486 SGTC_1729 st035615 45.989 µM -0.873765045865769 0.180725680751123 no 2797 0.19112310980242 3979 17385451 SGTC_2908 7930301 100 µM -0.875481417015716 0.18027240647659 no 2798 0.190656008533561 3929 2223178 SGTC_1377 2944-0135 198 µM -0.876758044677072 0.179935726595803 no 2799 0.19030903593845 3995 1894137 SGTC_2019 4016004 108 µM -0.878605627533779 0.17944917078837 no 2800 0.189807571732316 3972 45595336 SGTC_1137 ixabepilone 100 µM -0.880512787831888 0.17894779382666 no 2801 0.189290790367831 3904 154225 A novel microtubule stabilizer. SGTC_1825 st052143 62.6 µM -0.881298629047069 0.178741459256137 no 2802 0.18907810396723 3958 674173 SGTC_118 0083-0097 135.343 µM -0.884762336522843 0.177833796213765 no 2803 0.188142413467517 3977 5207356 SGTC_773 4358-1457 44.6 µM -0.887065733462854 0.177231804526939 no 2804 0.187521755704789 3915 1186886 SGTC_2924 9010168 62.78 µM -0.887833193170833 0.177031515476245 no 2805 0.187315242539056 4066 2993929 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.887948670458111 0.177001390985332 no 2806 0.187284181316534 3953 77254 SGTC_1329 1447-1697 50.6 µM -0.888704114474659 0.176804398667439 no 2807 0.187081059628116 3966 2840515 SGTC_2475 5812728 15.03 µM -0.890045715116159 0.176454899772863 no 2808 0.186720669811246 3928 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1410 3909-8106 77.9 µM -0.890273277525178 0.176395661122611 no 2809 0.186659583119707 3991 1039210 SGTC_2233 sulbentine 40.3845 µM -0.89104318918728 0.176195332366548 no 2810 0.186453000340256 3932 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3181 9108277 49.47 µM -0.891687711933861 0.176027740210859 no 2811 0.186280170868642 3885 17097298 SGTC_2240 6690706 185.951 µM -0.892534904685057 0.175807602323805 no 2812 0.186053146263219 3818 805876 SGTC_2771 fluoxetine 41.05 µM -0.892869838085105 0.175720620034755 no 2813 0.185963440554432 3943 3386 A selective serotonin reuptake inhibitor. SGTC_2991 9074669 71.4286 µM -0.893960066581839 0.175437676270559 no 2814 0.185671628804732 3952 17333109 SGTC_1980 st071811 45.7 µM -0.894458009129594 0.175308542849739 no 2815 0.185538443521274 4061 4974850 SGTC_168 3970-0862 530.542 µM -0.894513580302662 0.175294135095791 no 2816 0.185523583512272 3939 3135186 SGTC_2153 5569715 200 µM -0.894994247885304 0.175169545339641 no 2817 0.185395081429018 3978 2054701 SGTC_2092 5303694 80.6725 µM -0.898397002624789 0.174289153012256 no 2818 0.184486966948844 3964 1963699 SGTC_221 trifluoperazine 10.304 µM -0.901054573708021 0.173603520460328 no 2819 0.18377965201209 3937 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1316 1272-0050 65.9 µM -0.902352876676416 0.173269193326646 no 2820 0.183434722552424 3930 7340392 SGTC_2754 granisetron 64.02 µM -0.902376738035504 0.173263052606272 no 2821 0.183428386913151 3968 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_326 k292-0812 17.5 µM -0.902517831715686 0.173226744982319 no 2822 0.183390926677645 3943 3579357 SGTC_997 3996-0078 137 µM -0.903317696182107 0.17302100752767 no 2823 0.183178653607195 4010 735687 SGTC_151 3013-0144 2.285 µM -0.906255081796049 0.172266802922939 no 2824 0.182400427261603 3897 906558 YHR107C CDC12 SGTC_1994 st072947 40.9 µM -0.907402680174758 0.171972715702458 no 2825 0.182096946318318 4040 5286565 YDL195W SEC31 SGTC_442 cape 100 µM -0.908640600982522 0.171655841753606 no 2826 0.181769933853452 3916 5281787 SGTC_2627 acetyl isogambogic acid 100 µM -0.909123134641155 0.171532427401428 no 2827 0.181642566046635 4010 6857789 A caspase activator and apoptosis inducer. SGTC_2361 9034121 116 µM -0.909410362369351 0.171458992045672 no 2828 0.181566776995704 3975 6496917 SGTC_575 k072-0246 11.9 µM -0.909640300504626 0.171400218371754 no 2829 0.181506118870338 4011 6796779 SGTC_1846 st056244 14.8 µM -0.912574006564917 0.170651474648752 no 2830 0.180733315183998 4015 5393182 SGTC_1153 4055-0057 267 µM -0.913915758456055 0.170309730102981 no 2831 0.180380556302908 4032 882706 SGTC_916 4466-0038 42 nM -0.916807039430556 0.16957481146545 no 2832 0.179621881605645 4063 5722064 YGL116W CDC20 SGTC_2147 5545932 89.7195 µM -0.917194840540891 0.169476393433023 no 2833 0.179520274983685 4020 797404 SGTC_1024 4507-0395 26 µM -0.920814489022806 0.168559549801446 no 2834 0.178573644528055 4085 4201836 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.921471699767888 0.168393423413239 no 2835 0.178402104969915 4096 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_503 tyrphostin 8 294 µM -0.921961774533847 0.168269613362907 no 2836 0.178274257417601 3997 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.922934720298619 0.168023986755053 no 2837 0.178020612730818 4051 23847180 SGTC_738 1315-0003 72.4 µM -0.923008759574835 0.168005304501616 no 2838 0.178001320185613 4063 6251474 SGTC_1832 st054113 55 µM -0.923562007541986 0.167865746339307 no 2839 0.177857201117514 4014 1251267 SGTC_1383 3049-0032 20.7 µM -0.924536284715683 0.167620164014595 no 2840 0.177603584465093 4062 712864 SGTC_2112 5488546 200 µM -0.927186069927256 0.166953413998342 no 2841 0.176914967058619 3974 600757 SGTC_3188 9110789 49.47 µM -0.92838854760363 0.166651406579435 no 2842 0.176603028496942 3989 849217 SGTC_2769 toremifene 3.73 µM -0.929155556592034 0.166458953267829 no 2843 0.176404238053618 4017 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1684 st024538 14.6195 µM -0.929778062377967 0.166302863362005 no 2844 0.176243003507574 3996 6732859 SGTC_443 clozapine 122 µM -0.931245819628669 0.165935205607031 no 2845 0.175863210626803 3895 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_446 go6976 132 µM -0.932643810183681 0.16558551249875 no 2846 0.175501952746285 4028 3501 A protein kinase C inhibitor. SGTC_2149 5554786 194.827 µM -0.933248798095721 0.165434328794245 no 2847 0.175345762383224 4027 745063 YPR165W RHO1 SGTC_939 1165-0479 45.3 µM -0.935163612123796 0.164956414346379 no 2848 0.174851993967029 4005 1377347 SGTC_2916 7875993 68.79 µM -0.93801943295573 0.164245298692648 no 2849 0.174117211734826 3882 1299250 SGTC_3048 9093155 49.47 µM -0.938123793620205 0.164219349998171 no 2850 0.174090397708572 3970 25236002 SGTC_141 0443-0274 32.331 µM -0.941822438829592 0.163301419559509 no 2851 0.173141777475366 4051 1627241 SGTC_1216 1165-0504 9.65 µM -0.94313614396208 0.16297618780926 no 2852 0.172805635162406 4066 6304004 SGTC_1984 st072354 53.1 µM -0.94369630087684 0.162837638857671 no 2853 0.172662432430714 3906 5762938 SGTC_223 busulfan 5 mM -0.946389842070778 0.162172489615223 no 2854 0.171974892253892 4037 2478 A DNA alkylator. SGTC_538 2922-0838 53.3 µM -0.948356005527844 0.161688079312099 no 2855 0.171474124133142 3987 777039 SGTC_1946 st076057 65.1 µM -0.950108266123803 0.161257164557959 no 2856 0.17102862173376 3963 953009 SGTC_1000 4048-0884 8.67 µM -0.95426491086192 0.160237964443257 no 2857 0.169974782461433 4089 13040088 SGTC_360 0957-0399 1.01 µM -0.955052759055858 0.160045261506312 no 2858 0.169775508584819 4054 6752301 YPR165W RHO1 SGTC_2345 9052315 157.45 µM -0.955233167415104 0.160001156036861 no 2859 0.16972989820262 4082 6469265 SGTC_3204 9114183 49.47 µM -0.955637048796325 0.159902445650191 no 2860 0.169627818432533 4025 17027248 SGTC_1581 himbacine 57.9 µM -0.956936048282633 0.15958523459385 no 2861 0.16929976742714 4034 5281825 An alkaloid muscarinic receptor antagonist. SGTC_501 nsc-95397 161 µM -0.956961646976154 0.159578987624755 no 2862 0.169293306794569 4103 262093 SGTC_826 1683-5028 118 µM -0.960109573993605 0.158812004246141 no 2863 0.168500035241672 4085 722377 SGTC_2954 9074818 52.69 µM -0.963014132265183 0.158106463848899 no 2864 0.167770215597133 4068 16648742 SGTC_1270 0831-1170 17.3 µM -0.963075646887655 0.158091543737952 no 2865 0.167754781044904 4026 6764716 SGTC_1127 asiatic acid 681.4 nM -0.963423852653129 0.15800710532818 no 2866 0.167667430435656 4008 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_791 1348-1292 225 µM -0.963483853138263 0.157992558458074 no 2867 0.167652381722977 4020 5437054 SGTC_3277 9138724 49.47 µM -0.964614831776688 0.15771852184679 no 2868 0.167368883888591 3984 15943418 SGTC_1401 3807-4679 7.6 µM -0.967207139942147 0.157091583153995 no 2869 0.166720246801065 3981 3291456 SGTC_464 bw-b 70c 158 µM -0.967898987885807 0.156924540143975 no 2870 0.166547409931932 4091 5353454 SGTC_981 1488-1094 54.9 µM -0.968160973157922 0.156861315707751 no 2871 0.166481991193754 4017 3449522 SGTC_3075 9116269 49.47 µM -0.969927032471394 0.156435553150812 no 2872 0.166041432232963 4084 17015205 YNL244C SUI1 SGTC_1493 4348-0038 111 µM -0.970401016041046 0.156321414582288 no 2873 0.165923321215612 4033 800424 SGTC_765 1319-0117 244 µM -0.970438044307444 0.156312500226568 no 2874 0.165914096503221 4007 3487746 YGL099W LSG1 SGTC_2183 6420625 130.508 µM -0.972728231268413 0.155761800861715 no 2875 0.16534419514318 4037 2897619 SGTC_872 0588-0139 234 µM -0.973074745432367 0.155678589476673 no 2876 0.165258077310275 4017 2047100 SGTC_2646 retinol 96.75 µM -0.973558156590018 0.155562552842932 no 2877 0.165137985497224 4075 445354 A vitamin A analog and teratogen. SGTC_2860 9025725 38.96 µM -0.973651261715079 0.155540210708673 no 2878 0.16511486226968 4079 40546248 SGTC_1693 xanthone 101.9 µM -0.973741776979392 0.155518492084273 no 2879 0.165092384259324 4099 7020 An insecticide. SGTC_366 0181-0206 4.31 µM -0.974969701244101 0.155224056294028 no 2880 0.164787644750102 4081 274874 SGTC_1573 oleylamine 1.06 µM -0.975256220538123 0.15515540671948 no 2881 0.164716590426819 4055 5356789 An amine of the fatty acid oleic acid. SGTC_940 3232-1287 54.8 µM -0.979717974224561 0.154088964100752 no 2882 0.163612675584743 3985 1585493 YIL048W NEO1 SGTC_2967 9089538 49.85 µM -0.980877429066545 0.153812628380364 no 2883 0.16332659461478 4084 728216 SGTC_1971 st069429 63.5 µM -0.983730095786635 0.153134142436284 no 2884 0.162624119033332 4042 1246522 YGL099W LSG1 SGTC_1620 st003704 16.5 µM -0.984679559431317 0.152908760082925 no 2885 0.162390748109653 3994 2834414 SGTC_2062 5245942 200 µM -0.984884339711389 0.15286017847563 no 2886 0.162340443268278 4131 1376160 SGTC_2670 beta-carotene 100 µM -0.986022900625076 0.152590255549123 no 2887 0.162060937638695 3996 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_624 k048-0052 28 µM -0.98819720513163 0.152075664078517 no 2888 0.161528038347726 4070 6835531 SGTC_1200 1643-0193 18.4 µM -0.989315334992898 0.151811486137548 no 2889 0.161254441740061 4094 5403974 SGTC_115 0527-0192 112.043 µM -0.99198820288776 0.151181210259916 no 2890 0.160601640116661 4075 4233931 SGTC_2948 9070189 9.45 µM -0.993976751129294 0.15071343136687 no 2891 0.1601170930898 4027 6473636 YDL196W YDL196W SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.995936591228605 0.150253349642466 no 2892 0.159640477514891 4077 3256 An antibiotic and ribosome inhibitor. SGTC_3236 9132701 49.47 µM -0.995952665959157 0.150249579897787 no 2893 0.15963657212695 4073 24282524 SGTC_2335 9018011 154.17 µM -0.996534405749684 0.150113196359818 no 2894 0.159495279355945 4091 6458208 SGTC_1515 3460-0031 42.1 µM -0.998807507706276 0.149581079985793 no 2895 0.158943974201479 4022 2876596 SGTC_3040 9091894 49.47 µM -1.00080147110396 0.149115345457918 no 2896 0.158461399103408 3951 25236966 SGTC_272 doxorubicin 8.13 µM -1.00329671810971 0.148533890762818 no 2897 0.157858859570833 4081 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1344 1488-0097 29.1 µM -1.00517510364974 0.148097181644175 no 2898 0.157406270530828 4128 747966 SGTC_1508 1080-0625 72.9 µM -1.00540075546902 0.148044777330941 no 2899 0.157351958120891 3956 767111 SGTC_2107 5363541 170.161 µM -1.0054389977165 0.148035897361936 no 2900 0.157342754768921 4062 244052 SGTC_800 3448-7362 155 µM -1.00582741299247 0.14794572632262 no 2901 0.157249299075097 4166 15991913 SGTC_1851 st056236 18.9 µM -1.00668113906173 0.147747662105367 no 2902 0.157044014330478 4109 5393171 SGTC_163 TUB2.036 7.546 µM -1.00669701303635 0.147743981029837 no 2903 0.157040198985944 4080 15992207 YJR013W GPI14 SGTC_1477 0139-0234 16 µM -1.00758653809966 0.14753780387133 no 2904 0.156826497124513 4111 620880 SGTC_3016 9080866 49.47 µM -1.00941863901375 0.14711376085631 no 2905 0.156386951570473 4082 17066299 SGTC_1075 aripiprazole 15.2 µM -1.00960780997149 0.147070023489886 no 2906 0.15634161318042 4139 60795 An atypical antipschotic. YIL048W NEO1 SGTC_808 0711-0032 135 µM -1.01121017471376 0.14669989767396 no 2907 0.155957923506833 4020 4252555 SGTC_3347 9188721 44.724 µM -1.0116782573099 0.14659189462454 no 2908 0.155845957363517 4129 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1863 st057641 20.1 µM -1.01192872345672 0.146534125234249 no 2909 0.155786067211518 4114 3921635 SGTC_1670 st016595 4.04 µM -1.01371376399332 0.146122852651816 no 2910 0.155359677204069 4108 597879 SGTC_426 0988-0037 14.6 µM -1.01402548598567 0.146051111639392 no 2911 0.155285295693351 4154 5383008 SGTC_1959 st077091 55.8 µM -1.01434761830934 0.145976999614944 no 2912 0.155208454821063 4097 821356 YKL052C ASK1 SGTC_1734 st037168 69.4 µM -1.01672554465232 0.145430698987161 no 2913 0.154642005111592 4167 708907 SGTC_3213 9129884 49.47 µM -1.01823216429789 0.14508528336458 no 2914 0.1542838186707 4120 17190742 SGTC_2433 5607874 27.82 µM -1.01911779178031 0.144882497597973 no 2915 0.154073524255491 4078 2252428 SGTC_86 0417-1630 471.922 µM -1.02101281352651 0.144449227994847 no 2916 0.153624183978901 4113 3634867 SGTC_1376 2910-0861 41.3 µM -1.0224214837446 0.14412772201546 no 2917 0.153290728308178 4055 1112859 SGTC_491 tetrandrine 80.3 µM -1.02380558759925 0.143812293198278 no 2918 0.152963555338621 4129 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1361 1608-0041 5.61 µM -1.02407804175977 0.143750257463216 no 2919 0.152899207494653 4087 X1361 SGTC_431 k089-0097 107 µM -1.02763425463854 0.142942190862207 no 2920 0.152060952339262 3933 5499420 SGTC_1038 k292-0204 154 µM -1.02847496681035 0.142751608083965 no 2921 0.151863230204877 4086 4454212 SGTC_2123 5259487 200 µM -1.02858580242021 0.142726495352606 no 2922 0.151837176181562 4135 2173474 SGTC_2185 6113692 200 µM -1.03431439306352 0.141432597671037 no 2923 0.150494605169312 4140 874150 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.03557204122555 0.141149604382922 no 2924 0.150200920553019 4111 390807 SGTC_452 diindolylmethane 8 µM -1.03692158633905 0.140846359965653 no 2925 0.149886201418528 4127 3071 Inhibits expression of several cancer promoting factors. SGTC_1967 st070177 51.4 µM -1.0423941719498 0.13962119585395 no 2926 0.148614483715122 4176 5729214 SGTC_279 1273-0055 2.93 µM -1.04254511569697 0.139587506639109 no 2927 0.148579509984717 4145 2847562 SGTC_2567 aureobasidin a 60 nM -1.04268093053726 0.139557198778016 no 2928 0.148548046331972 4295 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3322 9139058 2.11 µM -1.04715396211055 0.138561516585643 no 2929 0.147514287313227 4225 4908926 YPR165W RHO1 SGTC_2179 6298986 200 µM -1.04731883941667 0.138524908162158 no 2930 0.147476274966325 4133 738374 SGTC_2667 digitoxin 100 µM -1.05446596357792 0.136944333971267 no 2931 0.145834817855195 4079 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2065 5221596 34.26 µM -1.05651035610128 0.136494495926867 no 2932 0.145367555995166 4149 788581 SGTC_2265 7929201 200 µM -1.05706051748522 0.13637361390856 no 2933 0.145241984484916 4108 1265108 SGTC_964 1287-0107 19.4 µM -1.05707213327631 0.13637106246487 no 2934 0.145239334027242 4167 51516812 YPR165W RHO1 SGTC_467 ro 31-8220 72.8 µM -1.05905039801228 0.135937006956578 no 2935 0.144788413996295 4088 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_354 2783-3500 4.88 µM -1.05998352784085 0.135732595516621 no 2936 0.144576046612609 4166 6740761 SGTC_2052 5265182 7.135 µM -1.06038769669923 0.135644123654038 no 2937 0.144484128559013 4159 1239884 SGTC_2706 st078239 82.5 µM -1.06293686782418 0.135087024912048 no 2938 0.143905291143047 4129 15434492 SGTC_1491 4138-0063 26.5 µM -1.06604963607901 0.134408887407882 no 2939 0.143200602332296 4128 23883227 SGTC_2208 7283366 200 µM -1.06685581313008 0.134233638048322 no 2940 0.143018475350071 4136 898663 SGTC_1296 1068-0102 11.9 µM -1.06694388024656 0.134214503248301 no 2941 0.14299858920948 4170 767053 SGTC_891 0929-0073 133 µM -1.06750317269383 0.134093026602684 no 2942 0.14287234086706 4188 5603632 SGTC_718 1130-0073 349 µM -1.0681491541366 0.133952815397252 no 2943 0.142726618110526 4193 6740020 SGTC_3230 9131665 49.47 µM -1.07051273476864 0.133440655681872 no 2944 0.142194289956007 4125 15943720 SGTC_734 2023-0417 80 µM -1.07061928404996 0.133417599495346 no 2945 0.142170324504082 4156 3935732 SGTC_219 mitoxanthrone 164.414 µM -1.07274803453102 0.132957533653822 no 2946 0.141692091045659 4111 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2985 9022375 71.43 µM -1.07336873535784 0.132823593610317 no 2947 0.14155285320901 4237 4939335 SGTC_3118 9124250 49.47 µM -1.07737041672303 0.131962307808356 no 2948 0.14065740749239 4093 1504786 SGTC_3087 9117406 49.47 µM -1.07840557891893 0.131740137341576 no 2949 0.140426399199339 4193 42546093 SGTC_979 1426-2828 121 µM -1.07929418494528 0.131549627294966 no 2950 0.140228302179347 4274 747872 SGTC_1784 st039334 36.3 µM -1.07951110214548 0.131503150866656 no 2951 0.140179973645529 4232 3496984 SGTC_136 0097-0015 404.482 µM -1.08123053439506 0.131135148315492 no 2952 0.139797289347258 4164 4861337 SGTC_143 4032-1194 15.74 µM -1.08130682766201 0.131118836100507 no 2953 0.139780325657276 4188 1806963 SGTC_3354 9151612 71.43 µM -1.08234142605744 0.130897767653905 no 2954 0.139550422455078 4189 27261949 SGTC_598 3937-0236 20.2 µM -1.0835988929876 0.130629424591369 no 2955 0.139271340942615 4247 1379313 SGTC_1341 1486-1360 280 µM -1.08389035881766 0.130567280206757 no 2956 0.139206707430594 4165 3976547 SGTC_2931 9014674 55.67 µM -1.08433787329911 0.130471903973452 no 2957 0.139107509350729 4136 2996810 SGTC_2518 prenyletin 46.28 µM -1.08478256226941 0.130377177664514 no 2958 0.139008985256484 4148 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3324 9138759 60.749 µM -1.08586582558812 0.130146623292854 no 2959 0.138769179192915 4228 45595710 SGTC_468 gf-109203x 121 µM -1.08878314507415 0.129527124514161 no 2960 0.138124763017403 4163 2396 A protein kinase C inhibitor. SGTC_1913 st060213 96.1 µM -1.09257424416794 0.128725133488811 no 2961 0.137290388112785 4232 688959 SGTC_3317 9138495 8.753 µM -1.09348053639351 0.128533922534793 no 2962 0.137091435069335 4096 17020139 SGTC_2032 5185112 25.99 µM -1.09370120909473 0.128487394521076 no 2963 0.137043021913936 4069 5718189 SGTC_1471 k673-0312 37 µM -1.09508995764384 0.128194850378127 no 2964 0.136738613906146 4139 24099884 SGTC_1155 4088-0394 48.2 µM -1.09572853022455 0.128060488475229 no 2965 0.136598796670913 4146 2326248 SGTC_1711 st032263 62.8 µM -1.09685486709988 0.127823734716437 no 2966 0.136352420461093 4196 3958979 SGTC_1265 0819-1001 68.8 µM -1.09724598183902 0.127741594376802 no 2967 0.136266938735392 4147 3106768 SGTC_2499 avocadenofuran 51.48 µM -1.09747094579968 0.127694364976879 no 2968 0.136217787406549 4166 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2663 amphotericin b 100 µM -1.09801117432269 0.127580997858475 no 2969 0.136099804943804 4199 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1277 0873-0036 22 µM -1.10040474686035 0.127079547894133 no 2970 0.135577905589904 4264 5965735 SGTC_4 0960-0234 25.671 µM -1.10323962010134 0.126487422297367 no 2971 0.134961559907147 4205 6821112 SGTC_2472 5377652 49.4 µM -1.10435701162649 0.126254559442631 no 2972 0.134719150425371 4268 1610903 SGTC_458 nppb 133 µM -1.10573872173589 0.125967026328786 no 2973 0.134419812442876 4239 4549 A chloride channel blocker. SGTC_199 4063-0024 41.6 µM -1.10642356385506 0.125824680435332 no 2974 0.134271615504685 4208 306215 SGTC_1047 2043-3044 82 µM -1.10703372893325 0.125697950866072 no 2975 0.134139672920133 4191 669592 SGTC_795 0685-0265 78 µM -1.10838255680839 0.125418119187653 no 2976 0.133848317448769 4209 302754 SGTC_2685 mycophenolic acid 18.85 µM -1.10854304986494 0.125384851810639 no 2977 0.133813678897714 4179 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1488 4013-0813 75.9 µM -1.1092027465617 0.125248173030088 no 2978 0.133671364013394 4134 2910057 SGTC_1246 0422-0085 105 µM -1.11013478948343 0.125055245758503 no 2979 0.133470473920943 4231 264295 SGTC_680 0417-1641 114 µM -1.11122799559397 0.124829223300517 no 2980 0.133235111876281 4197 2835990 SGTC_2028 5153890 36.43 µM -1.11502929803536 0.124045519274889 no 2981 0.132418933480566 4189 2830968 YPR165W RHO1 SGTC_2110 5483698 200 µM -1.11790256094395 0.123455435788175 no 2982 0.1318043055888 4181 2848765 YHR062C RPP1 SGTC_1169 aniline yellow 25.8 µM -1.11831482506537 0.123370930464411 no 2983 0.131716278714359 4134 6051 A DNA damaging agent. SGTC_2212 7123476 200 µM -1.11865879680178 0.123300454636042 no 2984 0.13164286471919 4190 1085715 SGTC_3262 9137218 49.47 µM -1.12112879902982 0.122795208292017 no 2985 0.131116520817937 4115 17650664 SGTC_1671 st016596 74.5 µM -1.12132822978036 0.122754477576656 no 2986 0.131074086736899 4278 2829167 SGTC_2126 5251174 33.877 µM -1.12489972871402 0.122026656854918 no 2987 0.130315763478841 4225 790722 SGTC_19 0279-0214 38.434 µM -1.12535788851811 0.121933510177484 no 2988 0.130218704182753 4282 3566274 YBR002C RER2 SGTC_1041 0206-0046 107 µM -1.12611768821924 0.121779148380841 no 2989 0.130057853976405 4216 50494 SGTC_1705 st027868 56.3335 µM -1.12764267498659 0.121469744738308 no 2990 0.129735428176175 4157 292948 SGTC_3111 9122088 49.47 µM -1.12893837410844 0.121207295699868 no 2991 0.129461915649306 4065 16876704 SGTC_1495 4469-0029 237 µM -1.12906089580846 0.121182499094652 no 2992 0.129436072913803 4229 793680 SGTC_2450 5739737 12.93 µM -1.13301060646545 0.120385046089989 no 2993 0.128604899613876 4246 2262825 SGTC_502 l-744,832 89.3 µM -1.13384750465892 0.12021655064522 no 2994 0.128429260185082 4244 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2084 5306078 60.6385 µM -1.13581161643981 0.119821762384996 no 2995 0.128017707168369 4143 679340 SGTC_1472 k841-0093 193 µM -1.13586201782409 0.119811643704498 no 2996 0.128007158311822 4335 X1472 SGTC_1013 4112-3890 241 µM -1.13948675634228 0.119085513289246 no 2997 0.127250094493476 4164 705171 SGTC_717 1532-0246 73.2 µM -1.14182091720978 0.118619567249366 no 2998 0.126764232955772 4213 9561992 SGTC_2603 homopterocarpin 100 µM -1.14616516746605 0.117755799486822 no 2999 0.125863408740765 4219 101795 A weak amylase inhibitor. SGTC_3218 9131285 49.47 µM -1.14738427560039 0.117514205910113 no 3000 0.125611418543177 4216 17156417 SGTC_1161 k007-0610 110 µM -1.14749054238113 0.117493163407965 no 3001 0.125589469843558 4213 5843850 SGTC_1186 1319-0216 26 µM -1.15089008678708 0.116821407200756 no 3002 0.124888728291077 4316 4565136 SGTC_1912 st060209 90.8 µM -1.15111585909987 0.116776890785068 no 3003 0.124842287203687 4237 688787 SGTC_2532 xanthone 78.9 µM -1.15610095690929 0.115797022346738 no 3004 0.123819932342512 4248 7020 An insecticide. SGTC_2150 5556613 200 µM -1.16029154626388 0.114977850840049 no 3005 0.122965062609342 4250 743190 SGTC_1064 honokiol 6.76 µM -1.16382118951967 0.114291084747339 no 3006 0.122248241556565 4269 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_361 000s-0510 1.45 µM -1.16508928309886 0.114045065211488 no 3007 0.121991427213103 4180 660 SGTC_2645 abamectin 100 µM -1.16808284519819 0.113465789118664 no 3008 0.121386674658383 4217 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2863 9028737 58.44 µM -1.1712072432568 0.11286343635815 no 3009 0.120757742261285 4240 6460917 SGTC_1926 methyl fluorone black 53.6 µM -1.17179593799022 0.112750197942758 no 3010 0.120639496964437 3929 72721 Reacts with homocysteine. SGTC_222 nsc-310342 10.666 µM -1.17201099939034 0.11270885003071 no 3011 0.120596320041256 4274 432556 SGTC_194 1486-1323 56.904 µM -1.17328008822122 0.11246507425292 no 3012 0.120341752249659 4348 5178754 SGTC_1742 st038235 28.8875 µM -1.17334425669247 0.112452758319914 no 3013 0.120328890693387 4307 564103 YBR002C RER2 SGTC_88 0180-0332 8.668 µM -1.17339740722631 0.112442557802672 no 3014 0.120318238241808 4335 3101745 SGTC_967 1306-0166 352 µM -1.17594475035838 0.111954452900181 no 3015 0.119808477397085 4273 4437607 SGTC_2755 lomerizine 42.69 µM -1.17898019211653 0.111374802412956 no 3016 0.119203031669223 4223 3949 A calcium channel blocker. SGTC_2847 9005661 71.43 µM -1.18048741705411 0.111087780964899 no 3017 0.118903206052411 4286 2991449 SGTC_287 k060-0039 29.6 µM -1.18123348785156 0.110945902564452 no 3018 0.118754990704402 4305 5861974 SGTC_2804 7954240 19.48 µM -1.18312373732437 0.110587019741885 no 3019 0.118380055776437 4290 828705 SGTC_2886 9058944 51.95 µM -1.1843516290299 0.110354338455889 no 3020 0.118136949680255 4146 4949929 SGTC_422 cantharidin 155 µM -1.18610172571356 0.110023308180261 no 3021 0.117791064561476 4186 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_865 0488-0499 301 µM -1.18630080170621 0.109985698193281 no 3022 0.11775176507811 4227 9634651 SGTC_1867 st057372 64 µM -1.187679117063 0.109725556064744 no 3023 0.11747992710715 4233 688837 SGTC_2235 salicylic acid 500 µM -1.18843389094907 0.109583287956615 no 3024 0.117331255400509 4300 338 A COX inhibitor and kinase inhibitor. SGTC_2231 micatex 6.853 µM -1.19379262565542 0.10857702190363 no 3025 0.116279548508484 4293 20737 An antifungal of unknown mechanism. SGTC_3269 9137823 49.47 µM -1.19631707864905 0.108105288791793 no 3026 0.11578642325151 4200 17682936 SGTC_737 1950-0117 57.9 µM -1.19737231315265 0.107908539806531 no 3027 0.115580735104291 4285 5393513 SGTC_2716 st080858 38.6235 µM -1.19838881031087 0.107719257394209 no 3028 0.115382843307031 4250 5296050 SGTC_613 3914-0030 117 µM -1.20004687186103 0.107411022459408 no 3029 0.115060568615897 3992 1145395 SGTC_3010 9080089 71.4286 µM -1.20026345673527 0.107370806156118 no 3030 0.115018518684376 4300 17027233 SGTC_2743 auranofin 4.32 µM -1.20094218861245 0.107244846947584 no 3031 0.11488681374972 4298 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1117 retinoic acid 1.10837 µM -1.20103660359264 0.107227333839588 no 3032 0.114868501440819 4320 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2843 9000894 45.46 µM -1.20199640092619 0.107049417308404 no 3033 0.114682461258842 4223 2242070 SGTC_370 0180-0345 38.7 µM -1.20210416493855 0.107029454520045 no 3034 0.114661586456726 4130 3989527 SGTC_43 0570-0105 72.5 µM -1.20497708323066 0.106498249229599 no 3035 0.114106074450184 4282 1114046 YDL195W SEC31 SGTC_803 4488-1585 147 µM -1.2069186608425 0.106140329207361 no 3036 0.113731735179646 4275 747204 SGTC_857 0438-0306 1.35 µM -1.20763768615058 0.106008001267138 no 3037 0.113593328301623 4350 4686136 SGTC_1420 4'-methoxyflavone 42 µM -1.20782028343834 0.105974415426238 no 3038 0.113558198847349 4274 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1841 st054148 70 µM -1.20852562451577 0.10584475147332 no 3039 0.113422572722705 4317 675442 SGTC_2910 7948405 25.97 µM -1.21021106831692 0.1055353781764 no 3040 0.113098956015037 4218 2971328 SGTC_2739 tacrine 100.86 µM -1.21392124369778 0.104856658648661 no 3041 0.112388899916076 4351 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1779 st039427 55 µM -1.21440365438869 0.104768641742041 no 3042 0.112296810312759 4283 1124498 SGTC_712 r015-0009 80.6 µM -1.21759685834736 0.104187383464603 no 3043 0.111688604443201 4332 6813872 YLR060W FRS1 SGTC_3060 1327-0027 12.5 µM -1.22207536454065 0.103376105569629 no 3044 0.110839564157427 4222 16000455 YPR107C YTH1 SGTC_1097 itavastatin 7.23 µM -1.2295394676575 0.102034196711799 no 3045 0.109434804815105 4325 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3042 9091578 49.47 µM -1.23069287985879 0.101827970164826 no 3046 0.109218876051657 4303 25236497 SGTC_867 0518-0118 155 µM -1.23327286672027 0.101367775162838 no 3047 0.108736988738872 4294 6848158 SGTC_885 0865-0106 16.8 µM -1.23598539086359 0.100885575162588 no 3048 0.108231997044034 4269 2793380 SGTC_892 0929-0076 29 µM -1.23872850413568 0.100399640395068 no 3049 0.107723029469338 4294 5751038 SGTC_2794 7785382 27.27 µM -1.24007840250371 0.100161137741639 no 3050 0.107473198233538 4307 2205081 SGTC_1776 st049249 45.9 µM -1.24073192268822 0.100045821236059 no 3051 0.10735239870145 4337 1822314 SGTC_2829 7992743 58.44 µM -1.24461891400495 0.0993619470933039 no 3052 0.106635932260531 4324 16462845 SGTC_2738 aclarubicin 5.55 µM -1.24704736291798 0.0989364258704932 no 3053 0.106190065785816 4324 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_466 geldanamycin 89.2 µM -1.24794296429154 0.0987798324758149 no 3054 0.106025972544287 4317 5288382 HSP90 inhibitor. SGTC_542 3381-0244 89.3 µM -1.25028465128557 0.0983712523050522 no 3055 0.105597791619114 4339 1112843 SGTC_2647 atorvastatin 60.16 µM -1.25415050548537 0.0976994441072858 no 3056 0.104893652932832 4301 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2866 9034245 58.44 µM -1.2578394675076 0.0970615185092964 no 3057 0.104224909489442 4333 6462273 SGTC_1124 fisetin 1.16336 µM -1.25874176545293 0.0969059521351225 no 3058 0.104061810285198 4337 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_589 1227-0070 34.1 µM -1.2616436772093 0.0964068709218669 no 3059 0.103538516074209 4387 2841384 SGTC_1379 2144-0755 36.5 µM -1.26693274804305 0.09550210051227 no 3060 0.102589668958089 4386 5392327 SGTC_73 0327-0325 16.231 µM -1.26920353314032 0.0951155739427688 no 3061 0.102184240632887 4174 53298 SGTC_2748 diazoxide 86.69 µM -1.26934946027731 0.0950907740981289 no 3062 0.102158226564324 4415 3019 A potassium channel activatior. SGTC_1162 k048-0130 20.1 µM -1.27109065805553 0.0947952305208808 no 3063 0.101848199195968 4301 6797406 SGTC_380 3970-0968 6 µM -1.27580876737294 0.093997801476748 no 3064 0.101011563782792 4221 2891601 SGTC_1969 st069479 40.1 µM -1.27590273559818 0.0939819699111133 no 3065 0.100994951967388 4356 3895485 SGTC_786 4544-0069 423 µM -1.2769140620886 0.0938117083170437 no 3066 0.100816294497193 4334 748821 YLR208W SEC13 SGTC_3175 9106517 49.47 µM -1.28319717233662 0.0927590158370021 no 3067 0.0997115031999606 4359 41468073 SGTC_2127 5253358 187.912 µM -1.28440490602344 0.0925576731208041 no 3068 0.0995001586270773 4256 20612 SGTC_742 0kpi-0133 140 µM -1.28714618513621 0.0921018712853796 no 3069 0.0990216701092386 4378 2728852 SGTC_1564 D-Arginine 115 µM -1.28850954453893 0.0918758005949284 no 3070 0.0987843242746807 4362 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3260 9137109 49.47 µM -1.29127908290125 0.0914178248386832 no 3071 0.0983034605382344 4296 17478346 SGTC_2379 9035213 200 µM -1.29245011650334 0.0912246904820688 no 3072 0.0981006552208066 4350 646551 SGTC_3253 9135987 49.47 µM -1.29791053097742 0.0903281172795804 no 3073 0.0971590404433321 4357 4182430 SGTC_2090 5301565 104.445 µM -1.2980478569083 0.0903056536984775 no 3074 0.0971354452355524 4359 2056344 SGTC_1242 0402-0103 60.1 µM -1.29878592794358 0.09018499215367 no 3075 0.097008702624817 4294 432868 SGTC_340 k038-0059 454 µM -1.29905668894323 0.0901407575635398 no 3076 0.0969622376082393 4320 23733424 SGTC_1807 st050092 58.9 µM -1.30051524615944 0.0899027483459951 no 3077 0.0967122171455636 4379 5008496 SGTC_353 1988-1175 58.3 µM -1.30169425816654 0.089710697283759 no 3078 0.0965104615980993 4199 2788357 SGTC_58 0957-0393 9 µM -1.30392295569176 0.0893484948447442 no 3079 0.0961299262384644 4018 6997992 SGTC_2857 9024691 58.44 µM -1.30447043213735 0.0892596869896977 no 3080 0.0960366172533825 4419 16478292 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.30467676623704 0.089226233940207 no 3081 0.0960014680474071 4321 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1939 st074455 53.6 µM -1.30543435711834 0.0891034853638967 no 3082 0.095872492867817 4354 1644229 SGTC_415 dibenzyl ketone 100 µM -1.30619585296297 0.0889802307789232 no 3083 0.0957429813710841 4356 7593 SGTC_2746 daunorubicin 9.88 µM -1.30821603749715 0.0886538617329079 no 3084 0.0954000219838878 4354 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_188 3229-0966 278.469 µM -1.30886440368797 0.088549304759022 no 3085 0.0952901431365661 4413 5722370 SGTC_1519 esterone 74 µM -1.31217250195253 0.088017263172259 no 3086 0.0947309688277147 4343 698 A steroid. SGTC_2740 felodipine 17.08 µM -1.31316757118471 0.0878576934054415 no 3087 0.0945632443702133 4421 3333 L-type calcium channel blocker SGTC_2855 9016525 58.44 µM -1.31349336941104 0.0878054951647923 no 3088 0.0945083768662511 4321 43811474 SGTC_2236 dapsone 200 µM -1.31554242170649 0.0874777333877452 no 3089 0.0941638349982903 4383 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1981 st071826 47 µM -1.31923846126517 0.0868888336617393 no 3090 0.0935447019231805 4418 11838600 SGTC_858 0438-0351 2.77 µM -1.3218549084632 0.0864737421885867 no 3091 0.0931082350193357 4360 2799119 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.32257914652956 0.086359106406274 no 3092 0.0929876864534033 4374 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_936 3005-4620 401 µM -1.32331655939275 0.0862425020548745 no 3093 0.0928650635398852 4418 777207 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.32864116442514 0.0854040348191547 no 3094 0.0919831921694373 4379 521171 SGTC_2261 9010538 184.68 µM -1.33059977708859 0.0850971524260682 no 3095 0.0916603679482513 4385 6457250 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.33123782152298 0.0849973600253197 no 3096 0.0915553851005063 4389 688751 SGTC_26 0302-0163 425.158 µM -1.332325247102 0.0848274850116101 no 3097 0.0913766671612149 4447 3100915 SGTC_84 0443-0269 128.823 µM -1.34227408944489 0.0832851021613305 no 3098 0.0897535707113154 4324 6150058 SGTC_1173 0443-0020 122 µM -1.34393553530037 0.083029593484082 no 3099 0.0894846168648833 4392 5331295 SGTC_2644 guaiazulene 100 µM -1.34452890176964 0.0829384844898369 no 3100 0.0893887084667233 4415 3515 A coloring agent. SGTC_176 1486-1328 72.834 µM -1.3482587650089 0.0823675006707785 no 3101 0.0887875848445454 4444 22310231 SGTC_1484 3473-2379 286 µM -1.35113461778688 0.0819292772819253 no 3102 0.08832615699706 4530 671917 SGTC_1436 4092-1007 8.32 µM -1.3516142409538 0.0818563634046489 no 3103 0.0882493761073579 4401 2881121 SGTC_2463 5473429 200 µM -1.35360631480681 0.0815540451710594 no 3104 0.0879310055960927 4401 5399405 SGTC_1828 st055811 49 µM -1.36449875214483 0.0799158739806956 no 3105 0.0862053233350914 4419 5877589 SGTC_1105 epirubicin 18.1 µM -1.37060578237973 0.0790083580680656 no 3106 0.0852489397221829 4442 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_657 3534-0529 86.7 µM -1.37663936864459 0.0781194426508734 no 3107 0.0843118864148988 4459 1049549 SGTC_2384 9036245 200 µM -1.37682431982778 0.078092314523261 no 3108 0.0842832849453826 4355 6462766 SGTC_2688 kanamycin b 96.69 µM -1.37881759329844 0.0778004000775357 no 3109 0.0839755004500072 4424 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_435 c-PAF 6.7 µM -1.38256220343289 0.0772542432716371 no 3110 0.0833995725460248 4373 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_408 cantharidin 100 µM -1.38682356982326 0.07663626579103 no 3111 0.0827477840592432 4404 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1196 1588-0294 184 µM -1.38900752020462 0.0763210129909855 no 3112 0.082415231643738 4457 6144269 SGTC_2617 dihydrotanshinone i 20.83 µM -1.38939993830028 0.0762644722542509 no 3113 0.0823555845268201 4390 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_485 niflumic acid 177 µM -1.38970115460173 0.076221093765842 no 3114 0.0823098220383784 4457 4488 A COX2 inhibitor. SGTC_2274 7947094 46.08 µM -1.39609675864129 0.0753044820337999 no 3115 0.0813426798919542 4388 2971028 SGTC_3073 9114972 49.47 µM -1.39633637477338 0.0752703045075694 no 3116 0.0813066124955075 4440 41905075 SGTC_519 k048-0011 62.8 µM -1.39695515068528 0.0751821004156459 no 3117 0.0812135291779777 4454 6836379 SGTC_2289 7946404 165.07 µM -1.39771802148833 0.075073464658876 no 3118 0.0810988801636721 4403 1246120 YPR165W RHO1 SGTC_1351 1496-0003 46.5 µM -1.40068396826686 0.074652239570575 no 3119 0.0806542994220067 4448 3891978 SGTC_2215 7188065 200 µM -1.40092024432285 0.0746187612626156 no 3120 0.080618962122522 4473 940217 SGTC_1768 st044301 37.178 µM -1.40210434097919 0.0744511574158611 no 3121 0.0804420454902621 4451 3931349 SGTC_2459 5811157 9.22 µM -1.40518458716726 0.0740165079858214 no 3122 0.0799831980578461 4383 2870684 YBR192W RIM2 SGTC_14 0354-0009 295 µM -1.40711765619046 0.0737447269498391 no 3123 0.0796962516928255 4531 1713507 SGTC_1066 ketoconazole 628 nM -1.41343192345359 0.0728622826202982 no 3124 0.0787643823497439 4504 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_384 k007-0144 5.16 µM -1.41461286092342 0.0726981428926675 no 3125 0.078591017951053 4380 6824886 SGTC_2545 solidagenone 89.61 µM -1.4156702221931 0.0725514195449439 no 3126 0.0784360403747518 4348 6708572 An anti ulcer agent SGTC_335 4077-0256 27.6 µM -1.41640953835257 0.0724489641282746 no 3127 0.0783278164272116 4380 3121989 SGTC_2696 st077691 74.316 µM -1.42281834920656 0.0715654623861678 no 3128 0.0773944103464138 4462 757133 SGTC_1073 triclabendazole 3.09 µM -1.42637292004569 0.071079015581535 no 3129 0.0768803630578801 4479 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2388 9080168 200 µM -1.42648668641459 0.0710634885721069 no 3130 0.0768639536072721 4468 15943073 SGTC_2237 6667747 47.222 µM -1.42884369794024 0.0707423857099603 no 3131 0.0765245813701631 4450 729940 YDL015C TSC13 SGTC_3224 9130643 49.47 µM -1.42888449084674 0.0707368381989207 no 3132 0.0765187178896427 4467 17644395 SGTC_230 MPP+ 141.667 µM -1.42983172897548 0.0706081153237696 no 3133 0.076382660099897 4420 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1403 3909-7815 62.9 µM -1.43268289421493 0.0702217488020267 no 3134 0.075974240073389 4438 6615483 SGTC_790 1575-0012 79.1 µM -1.43474650556885 0.0699431209579989 no 3135 0.0756796733492116 4498 378741 YLR208W SEC13 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.4388407745269 0.0693928338225213 no 3136 0.075097820436841 4502 165506 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.44999928309611 0.0679100097057081 no 3137 0.0735293595680155 4490 688788 SGTC_3100 9120536 49.47 µM -1.45130714758005 0.0677378253575534 no 3138 0.0733471759459312 4357 16421196 SGTC_756 0508-1999 28.3 µM -1.45147386141076 0.0677159012281896 no 3139 0.0733239777845718 4477 6753853 SGTC_3356 9151811 4.48 µM -1.45242109294772 0.0675914371560759 no 3140 0.073192277426381 4486 1859254 YPR165W RHO1 SGTC_3183 9108214 49.47 µM -1.45490942696426 0.0672653177831594 no 3141 0.0728471688416567 4453 4974831 SGTC_1154 4088-0362 150 µM -1.4599979682106 0.0666022057557684 no 3142 0.0721453161677759 4478 6618304 SGTC_859 0439-0102 54.6 µM -1.46002777824808 0.0665983360297542 no 3143 0.0721412198525797 4518 610143 SGTC_1291 0993-0025 5.79 µM -1.4602996407792 0.066563052809115 no 3144 0.0721038703729496 4461 4353356 SGTC_629 3448-6466 76.7 µM -1.46777365230526 0.0655987068847012 no 3145 0.0710828583139295 4487 573744 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.47200952966932 0.0650569959205864 no 3146 0.0705091520986362 4483 616764 SGTC_623 k072-0108 16.9 µM -1.47287311231349 0.0649469827415039 no 3147 0.0703926266861003 4445 5382803 SGTC_822 1487-0950 154 µM -1.47909594282984 0.0641585109841138 no 3148 0.0695573372000285 4482 1958375 SGTC_1035 k081-0041 55.2 µM -1.4803621882426 0.0639989846151022 no 3149 0.0693883075868588 4497 731709 SGTC_3235 9132602 49.47 µM -1.48213733428535 0.0637758645027291 no 3150 0.0691518782982626 4470 4912240 SGTC_697 0508-1955 564 µM -1.48231320729886 0.0637537918097346 no 3151 0.0691284878484337 4491 6243113 SGTC_1704 st028805 70.8 µM -1.48270918355031 0.0637041171246482 no 3152 0.0690758468112202 4527 2876101 SGTC_2021 4019055 173 µM -1.48351714927826 0.0636028523245872 no 3153 0.0689685317710724 4272 44827708 YER133W GLC7 SGTC_2061 5245884 80.95 µM -1.48617580641335 0.0632705187696857 no 3154 0.0686163125643621 4462 573863 SGTC_2797 7859098 81.82 µM -1.48884881834011 0.0629377553791726 no 3155 0.0682635918500665 4440 972681 SGTC_3155 9099265 49.47 µM -1.48953650638769 0.0628523659469163 no 3156 0.068173073787799 4458 25236499 SGTC_1440 4100-1550 40 µM -1.4957900104044 0.0620800124990349 no 3157 0.0673541926891494 4525 742806 SGTC_1837 st055472 66.5 µM -1.49601956601125 0.0620518022406381 no 3158 0.0673242782524209 4535 676091 SGTC_862 0452-0056 10.2 µM -1.5093605649703 0.0604294338125098 no 3159 0.0656033324889647 4461 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1441 4106-0040 13 µM -1.50981957842882 0.0603742105973967 no 3160 0.0655447339410441 4536 2904180 SGTC_870 0573-2213 57.6 µM -1.5141017581241 0.0598609290277034 no 3161 0.0650000164192263 4489 3916321 SGTC_3200 9114385 49.47 µM -1.52055315433309 0.0590940969105481 no 3162 0.0641860050985653 4476 17018030 YLR208W SEC13 SGTC_1273 0849-0096 14.1 µM -1.52256614549358 0.0588564105305413 no 3163 0.0639336425245712 4533 5286025 SGTC_2796 7949634 45.45 µM -1.52971364444477 0.0580185173474428 no 3164 0.0630438123905309 4476 2971588 SGTC_478 N-arachidonylglycine 10 µM -1.53224585604807 0.0577239281051597 no 3165 0.0627308882873178 4549 5283389 SGTC_1523 st012844 44.7 µM -1.53365536519253 0.0575604606858917 no 3166 0.0625572299848582 4545 4274103 SGTC_2909 7941780 10.49 µM -1.54173727690004 0.0566301819331252 no 3167 0.0615687247745914 4478 1243215 SGTC_2479 5617353 43.85 µM -1.54814477129249 0.0559010910240558 no 3168 0.0607937224426321 4537 2731746 SGTC_2010 4012422 159 µM -1.56394673283043 0.0541346701808469 no 3169 0.0589150391731514 4479 952393 SGTC_372 0155-0182 15.9 µM -1.56491649342456 0.0540277209071648 no 3170 0.0588012454209868 4412 771486 SGTC_1605 st000082 49.1 µM -1.56739989231939 0.0537546037333292 no 3171 0.0585106245640487 4486 1114022 SGTC_1220 1838-0075 193 µM -1.57402873591895 0.0530309351690234 no 3172 0.0577404031122151 4464 5529645 SGTC_583 1488-1091 88.9 µM -1.5758515128582 0.0528333034904825 no 3173 0.0575300137579328 4625 4303273 SGTC_720 r052-1644 49.9 µM -1.58389914940467 0.0519677264673263 no 3174 0.0566083354983574 4541 1422863 YOR257W CDC31 SGTC_198 3454-2873 16.191 µM -1.58474516681639 0.0518773899733188 no 3175 0.0565121226312816 4542 710957 SGTC_1898 st060199 18.6 µM -1.58659063717322 0.0516807663797593 no 3176 0.0563026946754621 4534 688866 SGTC_1674 st016616 23.6 µM -1.58787602476097 0.0515441665439872 no 3177 0.0561571879476966 4500 625830 SGTC_691 1548-0686 185 µM -1.58983841374603 0.0513361747817268 no 3178 0.0559356163096003 4517 46495133 SGTC_1798 st045719 60.953 µM -1.59160156233734 0.0511498702237442 no 3179 0.0557371294127917 4512 3980186 SGTC_2702 st077768 96.8 µM -1.59511240846087 0.0507804962625264 no 3180 0.0553435505884139 4506 6484119 SGTC_477 mead ethanolamide 10 µM -1.59688835992236 0.0505944601298853 no 3181 0.0551452974581455 4548 16061185 SGTC_2760 etidronate 98.04 µM -1.59898380745482 0.0503756544628695 no 3182 0.0549121002888033 4502 3305 A chelator and antioxidant. SGTC_1416 3966-0321 25.3 µM -1.60108694157905 0.0501568050380742 no 3183 0.0546788320325492 4597 582530 YLR208W SEC13 SGTC_2269 7935389 174.42 µM -1.60190497721367 0.0500718863146382 no 3184 0.0545883118574434 4551 97605 SGTC_2213 7173844 200 µM -1.60317135817409 0.0499406518486404 no 3185 0.0544484135537916 4561 892728 SGTC_3355 9151058 44.0485 µM -1.60665067954593 0.0495815031954633 no 3186 0.0540655092424854 4565 17015728 SGTC_490 phenamil 164 µM -1.60694158337927 0.0495515686181964 no 3187 0.0540335916511205 4562 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3170 9103054 49.47 µM -1.60883071534535 0.0493575240369793 no 3188 0.0538266813247998 4517 16432970 SGTC_1294 1000-1494 117 µM -1.60957337132426 0.0492814075103642 no 3189 0.0537455126969154 4563 712797 YDL207W GLE1 SGTC_1417 3966-0327 90.4 µM -1.60982199886511 0.0492559460512281 no 3190 0.0537183606045872 4610 651118 SGTC_1133 3473-0247 50 µM -1.6122230995022 0.0490105942592378 no 3191 0.053456700190649 4516 711311 SGTC_1103 duloxetine 36.1 µM -1.61228821135883 0.0490039545527679 no 3192 0.0534496187031803 4600 60835 A selective serotonin reuptake inhibitor. SGTC_2541 muurolladie-3-one 83.07 µM -1.61709777909021 0.0485154881660429 no 3193 0.0529285881039251 4486 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1461 k072-0203 53.8 µM -1.61903381644904 0.048319963876169 no 3194 0.0527199936779443 4443 5418714 SGTC_3231 9132313 49.47 µM -1.61922820107545 0.0483003674531709 no 3195 0.0526990861838408 4523 4905967 SGTC_2995 9067767 71.4286 µM -1.62104336957837 0.0481176822758067 no 3196 0.0525041688986871 4539 11673567 SGTC_2438 5259590 200 µM -1.62345619335546 0.0478757033175365 no 3197 0.0522459603160335 4572 1201127 SGTC_636 0kpi-0074 126 µM -1.62423756172996 0.047797550056216 no 3198 0.0521625586007155 4568 616434 SGTC_592 k241-0073 46.5 µM -1.63005815063741 0.0472185787507021 no 3199 0.0515446037225432 4595 4230158 SGTC_2641 levomentholum 100 µM -1.63066002326279 0.0471590328197884 no 3200 0.051481038153736 4571 16666 SGTC_541 4513-1321 94 µM -1.63489243282627 0.0467419999514659 no 3201 0.0510357995389638 4527 747515 SGTC_2891 9063876 19.48 µM -1.63492760897941 0.0467385463700378 no 3202 0.0510321119809135 4592 6472478 SGTC_653 0203-0016 55.2 µM -1.63878818356239 0.0463607590423824 no 3203 0.0506286904771413 4611 295302 SGTC_926 2268-1401 59.4 µM -1.63936903418391 0.0463041310487908 no 3204 0.0505682133176039 4538 2931578 SGTC_973 1325-0077 65.9 µM -1.64246053880967 0.0460036694340792 no 3205 0.050247298841567 4576 2835149 SGTC_825 1988-2224 89.6 µM -1.64966072786293 0.0453099577424392 no 3206 0.0495061733855909 4559 1180859 SGTC_1178 0988-0033 191 µM -1.65125517370893 0.0451574825304504 no 3207 0.049343240650313 4621 5392207 SGTC_2890 9046729 58.44 µM -1.65153622666104 0.045130648577766 no 3208 0.0493145649327568 4552 903329 SGTC_2828 7998861 71.43 µM -1.65604969846582 0.0447014731277997 no 3209 0.0488558773659992 4586 2988188 SGTC_2469 5655019 90.81 µM -1.66582214594036 0.0437834954777578 no 3210 0.0478744219199162 4621 2788239 SGTC_3094 9117742 49.47 µM -1.66895379510806 0.0434925617122583 no 3211 0.047563268560562 4532 17149698 SGTC_1600 coumarin 106 71.1 µM -1.67059120033135 0.0433410673056453 no 3212 0.047401225896915 4621 100336 A hepatotoxic, DNA x-linker. SGTC_2638 epoxomicin 18 µM -1.67304422528472 0.043114908492355 no 3213 0.0471592950566688 4545 9915668 A protesome inhibitor. SGTC_1724 st037281 8.293 µM -1.67539384726099 0.042899177784338 no 3214 0.0469284915048061 4524 574124 YDL195W SEC31 SGTC_487 nimodipine 119 µM -1.67545067667787 0.0428939708113269 no 3215 0.0469229203871867 4598 4497 L-type voltage-gated calcium channels inhibitor SGTC_187 1488-2104 32.728 µM -1.67573805179676 0.0428676479997519 no 3216 0.0468947564698076 4578 2852859 SGTC_3090 9117696 49.47 µM -1.6760075122583 0.0428429779847727 no 3217 0.0468683605788991 4540 7923821 SGTC_1398 3558-0053 112 µM -1.67603421676636 0.0428405337219456 no 3218 0.0468657452996218 4558 4532369 SGTC_1534 6-azauridine 81.6 µM -1.67761177033895 0.0426963401569748 no 3219 0.0467114567523119 4621 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_801 0866-0028 10.1 µM -1.68003903506303 0.0424752467124576 no 3220 0.0464748605687185 4623 6849771 SGTC_956 1185-0240 191 µM -1.69102736016738 0.0414859052861103 no 3221 0.0454157886208885 4562 1416193 SGTC_1968 st069590 43.6 µM -1.69422275115082 0.0412017367404162 no 3222 0.0451114815772778 4554 6384066 SGTC_1451 4152-0210 104 µM -1.69648454405799 0.0410015492098976 no 3223 0.0448970773875642 4614 659563 SGTC_2634 4'-methoxyflavone 100 µM -1.69751467961437 0.0409106354577963 no 3224 0.0447996990879428 4579 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_861 0443-0273 110 µM -1.70365600011741 0.0403720264067868 no 3225 0.0442226864006679 4585 6149169 SGTC_1362 1611-0397 101 µM -1.70662150095963 0.0401140139108189 no 3226 0.0439462130869445 4590 27816 SGTC_3321 9137793 26.8275 µM -1.71506054773855 0.0393871008424413 no 3227 0.0431670632910797 4584 4904192 SGTC_3199 9111318 49.47 µM -1.71577172520334 0.0393263350525209 no 3228 0.0431019155751302 4512 8548020 SGTC_1438 4092-1045 4 µM -1.72081030861046 0.0388980003388945 no 3229 0.0426426255955692 4624 1351342 SGTC_226 1,3-diallylurea 8.28947 mM -1.72371825827038 0.038652526920814 no 3230 0.0423793586403663 4572 74537 YKL182W FAS1 SGTC_1338 1486-1223 76 µM -1.72593335792595 0.038466388296619 no 3231 0.0421797013179441 4601 3444526 SGTC_2259 7964009 200 µM -1.7307710723687 0.0380624066797933 no 3232 0.0417463016250929 4610 313134 SGTC_2262 9014885 67.46 µM -1.74123486192283 0.0372004444396349 no 3233 0.0408212093729421 4654 6457424 SGTC_1363 1636-0063 10.4 µM -1.74613738838035 0.0368021177944797 no 3234 0.0403935406801937 4615 6072185 SGTC_1770 st043884 66.3 µM -1.74980819863531 0.0365061562872637 no 3235 0.0400757077487253 4624 670149 SGTC_2290 7904846 200 µM -1.76401806169941 0.0353787845439087 no 3236 0.0388644691698158 4632 2962154 SGTC_3095 9117207 49.47 µM -1.76922666960212 0.0349727658858514 no 3237 0.0384280276134729 4622 17015229 SGTC_3126 9127922 49.47 µM -1.77014554492042 0.0349015365953658 no 3238 0.0383514490241618 4568 45595682 SGTC_2151 5563267 85.4165 µM -1.78953752826313 0.0334258804722252 no 3239 0.0367641446168695 4658 5310824 SGTC_1313 1220-0047 237 µM -1.79087798511456 0.0333258042150109 no 3240 0.0366564385951516 4628 3528706 SGTC_1666 st014829 29 µM -1.79177873722033 0.0332586942884503 no 3241 0.0365842080528421 4648 3858230 SGTC_559 1550-0661 158 µM -1.80271702574784 0.0324525919855526 no 3242 0.0357163334542363 4652 5830875 SGTC_1773 st048542 73.5835 µM -1.80507778853457 0.0322807462712798 no 3243 0.0355312551275456 4603 3237138 SGTC_3319 9138450 16.7555 µM -1.80821069770115 0.0320538544222683 no 3244 0.0352868571431439 4582 2029690 SGTC_694 1315-0438 43.2 µM -1.81129632785697 0.0318316753307843 no 3245 0.035047496911914 4665 6793154 SGTC_1506 4226-2149 212 µM -1.81237130628031 0.0317545715291099 no 3246 0.0349644216841907 4627 991114 SGTC_596 1155-0152 116 µM -1.82595411345911 0.0307935571382968 no 3247 0.0339285870087092 4657 280313 SGTC_2156 5649887 115 µM -1.83018604136044 0.0304991046234054 no 3248 0.0336110621700727 4664 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_668 1682-0499 62.6 µM -1.83307467008436 0.0302994596391165 no 3249 0.0333957337099111 4636 682214 SGTC_561 1550-0330 72.9 µM -1.83673717954306 0.0300478869070947 no 3250 0.0331243518926349 4612 6812934 SGTC_2029 5175081 200 µM -1.84914200972529 0.0292086508058461 no 3251 0.0322186548469074 4594 1380876 SGTC_419 nsc-638432 893 µM -1.85255583015856 0.0289811390693243 no 3252 0.0319730241717698 4631 368090 SGTC_3017 9080681 49.47 µM -1.86424146396527 0.0282134792129374 no 3253 0.0311439014764987 4665 16451914 SGTC_1772 st048439 82.2 µM -1.86550590014958 0.0281314394099597 no 3254 0.0310552629761378 4679 2927068 YDL195W SEC31 SGTC_704 1310-0270 142 µM -1.86920354228829 0.0278926660308872 no 3255 0.0307972508222572 4622 5718033 SGTC_547 1120-0019 610 nM -1.8736997917101 0.0276045999104128 no 3256 0.0304859073329045 4624 3676939 SGTC_2252 omeprazole 400 µM -1.89009046532186 0.0265753973583691 no 3257 0.0293729310428219 4688 4594 A proton pump inhibitor. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.8940127641621 0.0263339198068304 no 3258 0.0291116578269689 4647 2724278 An inhibitor of dopamine biosynthesis. SGTC_356 1634-0012 32.5 µM -1.90037670894423 0.0259460248478311 no 3259 0.0286918505961072 4658 735457 SGTC_616 4092-0450 108 µM -1.90093668254756 0.0259121233497814 no 3260 0.0286551532951456 4667 787165 SGTC_492 tmb-8 126 µM -1.91221817819936 0.0252369832470653 no 3261 0.0279241077224373 4697 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2025 5147754 141 µM -1.91258726017606 0.0252151469476258 no 3262 0.0279004559470782 4656 315777 YLR208W SEC13 SGTC_3318 9139014 38.6185 µM -1.91945099839827 0.0248119382992606 no 3263 0.0274636410360436 4649 16643984 SGTC_1930 st074634 34.3 µM -1.9298870866106 0.0242092437945588 no 3264 0.0268104148975551 4596 684253 YOR116C RPO31 SGTC_1400 3771-8998 51.5 µM -1.94407408003535 0.0234096904902537 no 3265 0.025943259217588 4660 670767 SGTC_1201 1889-3372 45.9 µM -1.95178424099853 0.0229845582888833 no 3266 0.0254819130233832 4588 5392199 SGTC_664 1222-0054 14.9 µM -1.96123928278712 0.0224721094289223 no 3267 0.0249255581989552 4667 6813991 SGTC_2831 7999036 19.48 µM -1.96513663550676 0.0222637008188728 no 3268 0.0246992126965812 4634 2988270 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.96517634131103 0.0222615859947019 no 3269 0.0246969156163875 4668 641818 YHR062C RPP1 SGTC_196 k015-0023 18.111 µM -1.96716944507761 0.0221556461935052 no 3270 0.0245818396597823 4643 5211998 SGTC_1616 st002734 56.1 µM -1.9718123846551 0.0219105081788287 no 3271 0.0243155140132742 4672 4026101 SGTC_871 0574-0004 149 µM -1.97565773755904 0.0217092187936965 no 3272 0.0240967772822116 4637 9551173 SGTC_1271 0832-2808 169 µM -1.9762887001758 0.0216763399962499 no 3273 0.0240610443387083 4700 3663794 SGTC_938 3126-1755 342 µM -1.98412921726015 0.0212712763835221 no 3274 0.0236207183857137 4675 1777771 SGTC_321 4534-3890 65.3 µM -1.99046523119088 0.0209486336855073 no 3275 0.0232698551858074 4693 699746 SGTC_2380 9035439 200 µM -1.99237635125989 0.0208521324253284 no 3276 0.0231648900445519 4710 6462575 SGTC_1164 k060-0068 93.7 µM -1.99291347226352 0.0208250785539073 no 3277 0.0231354614139023 4682 5963676 SGTC_1915 st067105 30.6 µM -1.99293516924129 0.0208239863387749 no 3278 0.0231342733075128 4617 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1252 0493-0875 34.8 µM -1.99687279967905 0.0206265694110801 no 3279 0.0229195013402735 4650 3960963 SGTC_147 4466-0538 29.23 µM -2.00866530738315 0.0200447986703386 no 3280 0.0222863201376214 4671 6742687 YHR072W ERG7 SGTC_3116 9124943 49.47 µM -2.0095082378028 0.0200037519836015 no 3281 0.022241630969765 4665 41905195 YPL160W CDC60 SGTC_3119 9125183 49.47 µM -2.01565019257904 0.0197068154447216 no 3282 0.0219182836461522 4655 22695334 SGTC_661 1304-0007 33.6 µM -2.01684698773514 0.0196493933852322 no 3283 0.0218557418531748 4708 3117130 SGTC_2946 9065502 71.43 µM -2.02415554056811 0.0193018042722219 no 3284 0.0214770752245539 4598 16489101 SGTC_2397 5161689 200 µM -2.02897145516553 0.0190756304985367 no 3285 0.021230598906127 4672 2259942 SGTC_394 menadione 8.33 µM -2.03902030521459 0.0186109474011679 no 3286 0.0207240005311986 4684 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2395 5646831 180.19 µM -2.04333392760158 0.0184144511381915 no 3287 0.0205096966094519 4640 6808628 SGTC_2523 spermine 47.74 µM -2.0452701456371 0.0183268277944705 no 3288 0.0204141161463717 4689 1103 A DNA binding polyamine. SGTC_1935 st074532 41.6 µM -2.04795905149676 0.0182057309887474 no 3289 0.0202820059472546 4675 2829742 SGTC_754 3474-0146 171 µM -2.06190172494766 0.0175886917842566 no 3290 0.019608546643702 4700 24762078 SGTC_2186 6124449 200 µM -2.08375204549764 0.0166576277779507 no 3291 0.0185913636984054 4701 3834182 YLR033W RSC58 SGTC_797 k781-0471 270 µM -2.08382687311202 0.0166545131994986 no 3292 0.018587958990318 4678 23738129 SGTC_3058 9093861 49.47 µM -2.09093767119663 0.0163608025287436 no 3293 0.0182668258099154 4710 17217477 SGTC_670 4204-0025 119 µM -2.09101107816132 0.0163577937440992 no 3294 0.0182635354618053 4690 719039 SGTC_1281 0884-0031 11.8 µM -2.10233874453623 0.0158991411583281 no 3295 0.0177618064555525 4713 1548255 SGTC_696 1560-0013 611 µM -2.11034792943417 0.0155815459491576 no 3296 0.0174141990145414 4711 1650269 SGTC_1964 st076914 61 µM -2.1238972510715 0.0150566549570436 no 3297 0.0168393681589863 4736 24208661 SGTC_550 4123-0385 25.7 µM -2.15495200511669 0.0139106454586126 no 3298 0.0155827950862314 4724 5731123 SGTC_1977 st070720 65.3 µM -2.1671688181013 0.01348087162902 no 3299 0.0151109920347495 4713 682188 SGTC_2669 eugenol 100 µM -2.17227779853119 0.0133045713631185 no 3300 0.0149173577943736 4747 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2248 tofa 1.1 µM -2.19100044941425 0.0126754071707011 no 3301 0.0142258799646399 4738 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_316 k060-0003 58.6 µM -2.19435133049974 0.0125655617852677 no 3302 0.0141050809570785 4745 6152314 SGTC_386 1509-0011 3.07 µM -2.21542925723148 0.0118933218989007 no 3303 0.0133653075084483 4721 3107280 SGTC_2963 9082507 9 µM -2.21789065322073 0.0118168925145167 no 3304 0.0132811444811199 4701 16459611 SGTC_3096 9117468 49.47 µM -2.23441679227459 0.0113146869713271 no 3305 0.0127278309117909 4727 41316311 SGTC_3284 9108171 64.8615 µM -2.24763550812546 0.0109264433991487 no 3306 0.0122997207202743 4709 8687505 SGTC_1183 1254-0324 198 µM -2.25180458272532 0.0108064235206488 no 3307 0.0121673119822779 4750 5799357 SGTC_1787 fluconazole 80 µM -2.25742516845449 0.0106464348018059 no 3308 0.0119907602590859 4405 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2825 7998094 58.44 µM -2.26256483800737 0.0105019450219404 no 3309 0.0118312638596917 4697 2987815 SGTC_2820 7989630 71.43 µM -2.26624746749986 0.0103994701073142 no 3310 0.0117181179186753 4748 2984098 SGTC_527 4476-4215 268 µM -2.27183864585197 0.0102455531694603 no 3311 0.0115481288701821 4730 4418754 SGTC_1443 4112-3303 14 µM -2.33062333072643 0.00874380546794805 no 3312 0.00988661507600052 4765 704433 SGTC_1972 st070201 17.4 µM -2.33288132644042 0.0086901869299567 no 3313 0.00982718735535509 4749 2829099 SGTC_619 1652-1634 108 µM -2.33605931540632 0.00861521070777238 no 3314 0.00974407516594387 4727 5400454 SGTC_645 0845-0943 5.41 µM -2.35249190023966 0.00823651078459392 no 3315 0.00932404795091211 4754 1885106 SGTC_3002 9075603 71.4286 µM -2.36681240431696 0.00791849013887343 no 3316 0.00897101231635365 4717 20105405 SGTC_3093 9117344 49.47 µM -2.37509574137633 0.00773951188288233 no 3317 0.00877219939997872 4758 24824913 SGTC_416 estradiol valerate 100 µM -2.39585120275508 0.00730659694842522 no 3318 0.00829091012025444 4750 13791 A steroid. SGTC_2806 7952793 58.44 µM -2.41017540931548 0.007020412855729 no 3319 0.0079724262084195 4733 2972490 SGTC_72 0744-0168 198.391 µM -2.41860691625797 0.00685662511790816 no 3320 0.00779003311305887 4696 677577 SGTC_383 2324-0395 7.37 µM -2.42123842112408 0.00680620204977127 no 3321 0.00773386432889442 4748 3146421 SGTC_3283 9109332 35.8195 µM -2.45488969705141 0.00618969118361503 no 3322 0.00704639116205918 4661 17027281 SGTC_2693 st077581 40.7 µM -2.46745825330567 0.00597243814254391 no 3323 0.0068038043765975 4724 25238761 SGTC_1631 benzylvanillin 81.9 µM -2.47165743783651 0.00590137508944005 no 3324 0.00672441592889975 4752 75506 SGTC_3071 9117417 49.47 µM -2.48731821554053 0.00564291570134988 no 3325 0.00643551068425718 4745 45595590 YGL055W OLE1 SGTC_1462 k081-0014 26.5 µM -2.49305627992944 0.00555076332037328 no 3326 0.00633243850053633 4280 3270634 SGTC_74 000s-0487 160.283 µM -2.49761124407141 0.0054785656893998 no 3327 0.0062516613907447 4694 677548 SGTC_3133 9127736 49.47 µM -2.49986474780404 0.00544315644300533 no 3328 0.00621203646775714 4749 27243420 SGTC_2443 5493264 126.67 µM -2.502303576638 0.0054050645042731 no 3329 0.00616940362159052 4779 5340055 SGTC_376 3970-0862 59.1 µM -2.50690957708868 0.00533376949643598 no 3330 0.00608959318711126 4763 3135186 SGTC_1456 k015-0012 13 µM -2.51583053736403 0.00519805879847945 no 3331 0.00593761330519115 4757 2989616 SGTC_3080 9117754 49.47 µM -2.55648618160004 0.00461771423022646 no 3332 0.00528676352916195 4752 9550191 SGTC_2605 digitonin 300 nM -2.57761929515841 0.00433950002802565 no 3333 0.00497417677260223 4756 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1945 st075991 56.6 µM -2.58650949770928 0.00422700888828562 no 3334 0.00484767491813957 4755 1084980 SGTC_900 1112-0045 141 µM -2.62594882324904 0.00375878628778547 no 3335 0.00432039038789657 4744 56211 YIL048W NEO1 SGTC_3007 9078383 71.4286 µM -2.63019779106207 0.00371122605927532 no 3336 0.00426676017294173 4779 6496995 SGTC_1402 3909-7673 35.9 µM -2.65078858519633 0.0034883061271835 no 3337 0.00401520453330297 4760 5328014 SGTC_1160 4092-0570 10.5 µM -2.65443943534434 0.00345006092216573 no 3338 0.00397201493820017 4766 4994975 SGTC_2859 9028643 45.46 µM -2.659073108278 0.00340206261171371 no 3339 0.00391779790820671 4693 17151580 SGTC_615 k087-0205 167 µM -2.66333073656847 0.00335848950283709 no 3340 0.0038685663044767 4776 9642773 SGTC_2555 cholic acid 100 µM -2.6659120736806 0.0033323166773484 no 3341 0.00383898855569479 4751 6708657 Influences liver metabolism. SGTC_3004 9076122 71.4286 µM -2.76618823414214 0.00244722790677036 no 3342 0.00283578934000028 4782 44782551 SGTC_1424 4048-1941 275 µM -2.77796553070712 0.00235863703274559 no 3343 0.00273502103073068 4801 X1424 SGTC_2584 androsterone 48.74 µM -2.83079024620251 0.00199593035630702 no 3344 0.00232165803253533 4727 2754130 A steroid. SGTC_946 3434-1334 87.4 µM -2.88311409792991 0.00168733443152467 no 3345 0.00196882393072071 4779 4047976 SGTC_540 1187-0821 17.3 µM -2.89554810502968 0.00162070309051389 no 3346 0.00189248506407587 4759 847520 SGTC_1933 st074711 15.9 µM -2.92044538553903 0.00149443781211861 no 3347 0.00174765727666094 4772 17250958 SGTC_2401 5128683 200 µM -2.95985691537903 0.00131280751379406 no 3348 0.00153890977013509 4765 708373 SGTC_2320 7373003 200 µM -3.07046358121353 0.000905479852411406 yes 3349 0.00106863374859575 4774 5415828 SGTC_2543 pimpinellin 60.67 µM -3.16179191386741 0.000660546532186077 yes 3350 0.000784007843579208 4769 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2608 thymoquinone 42.66 µM -3.37958024240698 0.000301604553677538 yes 3351 0.000362983059784763 4789 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2616 abietic acid 100 µM -3.38574294599211 0.0002947946400914 yes 3352 0.000354929218830368 4797 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1463 k081-0032 34.1 µM -3.49813296671049 0.000193146032753053 yes 3353 0.000234263740857459 4525 977755 SGTC_2583 asiatic acid 100 µM -3.53441742350571 0.000168067966900602 yes 3354 0.000204337555368489 4793 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2588 indole-3-carbinol 100 µM -3.75136441940382 7.12769209845374e-05 yes 3355 8.79374256242429e-05 4801 3712 Induces cell cycle arrest. SGTC_665 3914-0008 307 µM -4.45994436620106 3.15693163095097e-06 yes 3356 4.09904653633867e-06 4808 1069549