SGTCid condition conc unit RPL33B|YOR234C.score RPL33B|YOR234C.strain.pval RPL33B|YOR234C.strain.significant RPL33B|YOR234C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3148 9097893 49.47 µM 6.72117413100954 2.39644927218711e-10 yes 1 9.01330040715554e-12 11 17174100
SGTC_2867 9039098 71.43 µM 4.80078269459887 4.01469275582516e-06 yes 2 7.90233481764794e-07 18 6463460
SGTC_782 0083-0095 30.5 µM 4.63643332630679 8.02864521922675e-06 yes 3 1.77236230832541e-06 15 3591729 An indicator and reagent.
SGTC_2364 9055074 200 µM 4.58885386788459 9.77266468659286e-06 yes 4 2.22843139355583e-06 11 6470630
SGTC_1847 st056231 15 µM 4.53522749333491 1.21698163425149e-05 yes 5 2.8770714574373e-06 21 5393180
SGTC_52 0329-0193 875 nM 3.98534689263518 0.000101001148628796 yes 6 3.36908069672912e-05 29 3739292
SGTC_1789 tunicamycin 25 nM 3.76666682850958 0.000219107713427529 yes 7 8.27207732254101e-05 58 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1167 k781-0610 148 µM 3.75794265165818 0.000225804753751176 yes 8 8.56580653324078e-05 33 4525169
SGTC_1849 st056239 19.2 µM 3.64867790914091 0.000327547801164175 yes 9 0.000131796666285825 34 5393181
SGTC_2391 6285546 200 µM 3.58693571116476 0.000402477600642112 yes 10 0.000167293386370671 26 846083
SGTC_3036 9090181 49.47 µM 3.58479704313516 0.000405337961554851 yes 11 0.000168670215864276 9 25236586
SGTC_364 0083-0097 67.7 µM 3.52157232973689 0.000498919377155106 yes 12 0.000214497809394304 40 5207356
SGTC_2116 5511452 16.8835 µM 3.46144587595455 0.000606110837326939 yes 13 0.000268641071635641 26 870744
SGTC_139 0099-0334 718.624 µM 3.42390736313409 0.000683429829060096 yes 14 0.00030863829541588 57 97690
SGTC_2357 9067248 200 µM 3.39571287567461 0.000747377530639852 yes 15 0.000342250614573575 40 9150235
SGTC_1222 0366-0074 1.18 µM 3.29180979132021 0.0010336059357605 no 16 0.000497724565839772 37 286520
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.21307446521562 0.00131405267474414 no 17 0.00065661118478678 47 75037 A free radical scavenger.
SGTC_1770 st043884 66.3 µM 3.18721254091185 0.00142035966960525 no 18 0.000718255857552413 40 670149
SGTC_1857 st056007 79.3 µM 3.16943964668901 0.00149790723070203 no 19 0.000763665871602943 24 619834
SGTC_691 1548-0686 185 µM 3.11161267581272 0.00177770517509633 no 20 0.000930342255590481 81 46495133
SGTC_1352 1496-0991 99 µM 3.07998987473744 0.00195008166715963 no 21 0.00103503816142236 59 3000039
SGTC_685 1278-0033 54.9 µM 2.99485983322745 0.00249215283674183 no 22 0.00137285491931206 80 3590572
SGTC_1757 st041620 31.8375 µM 2.97077436746353 0.00266850853522716 no 23 0.00148524967387879 74 5289815
SGTC_2864 9034755 47.6 µM 2.96933109850567 0.00267942577656918 no 24 0.00149224415520854 47 4930451
SGTC_1937 st074714 47.2 µM 2.92789355378472 0.00301058461342948 no 25 0.00170633429571993 88 17250970
SGTC_2966 9084041 48.03 µM 2.92517985676504 0.00303350704035514 no 26 0.00172128595739273 88 17741380
SGTC_849 0386-0493 241 µM 2.92402481024637 0.00304331125414843 no 27 0.00172768602388768 59 726119
SGTC_1861 st057647 17.4 µM 2.87554339629856 0.00348146601770374 no 28 0.00201666348958252 65 688668
SGTC_2012 4023501 200 µM 2.8660943690311 0.00357318464282862 no 29 0.00207785172617586 88 3477460
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.85203740810021 0.00371364704474289 no 30 0.0021719994093881 105 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2869 9037858 32.47 µM 2.809205933166 0.00417267451628017 no 31 0.00248319336354444 55 27187042
SGTC_1423 4048-0112 5.59 µM 2.74452438591653 0.00496231667645162 no 32 0.00302993259986125 86 X1423
SGTC_2349 9023730 187.07 µM 2.74356104248185 0.00497502134637537 no 33 0.00303883736452373 103 4126287
SGTC_1091 telmisartan 47.6 µM 2.73411063083942 0.00510119899726742 no 34 0.00312745123250073 72 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_658 3253-0951 102 µM 2.72650393081901 0.00520482138585488 no 35 0.00320045950990249 145 1184878
SGTC_1978 st071761 42 µM 2.71507156572634 0.00536408282011991 no 36 0.00331307249206157 57 5147680
SGTC_771 0250-0039 27.3 µM 2.71137378597984 0.00541651518297373 no 37 0.00335025224349604 67 3005115
SGTC_3161 9100388 49.47 µM 2.70704617194446 0.00547845640632915 no 38 0.00339424076376957 52 25236368
SGTC_1293 1000-1278 195 µM 2.68125930030142 0.00586076331229695 no 39 0.00366728290967815 84 678847
SGTC_168 3970-0862 530.542 µM 2.67372099091309 0.00597690640840774 no 40 0.0037507416640474 287 3135186
SGTC_767 0929-0023 86 µM 2.66526267006504 0.00610964950157403 no 41 0.00384641047717105 204 1204563
SGTC_879 0831-1030 162 µM 2.64004538184095 0.0065210369226742 no 42 0.00414474630510351 152 1549252
SGTC_1016 4226-1401 38 µM 2.60849186932519 0.00707017374668389 no 43 0.00454710860850864 99 2901613
SGTC_1149 3909-7961 23.3 µM 2.60141295995483 0.00719883505823029 no 44 0.00464203104849977 124 735261
SGTC_2512 diallyl trisulfide 49.23 µM 2.59198449426848 0.00737340492327589 no 45 0.00477120361758227 56 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_779 1360-0071 233 µM 2.57909266464735 0.00761813379002155 no 46 0.00495301049101766 128 7566
SGTC_2489 cantharidin 73.42 µM 2.5336609991295 0.00853851762685372 no 47 0.00564389367619371 161 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_880 0833-0487 87.2 µM 2.50602995143153 0.00914480160580074 no 48 0.00610476383839655 112 76075
SGTC_1745 st081495 74 µM 2.49865856633992 0.00931278258488763 no 49 0.00623321784160275 221 13842402 YBL026W LSM2
SGTC_3023 9089636 49.47 µM 2.4835830169102 0.00966475377361948 no 50 0.00650340065861947 65 17249241
SGTC_522 1273-0010 11.6 µM 2.45823709618223 0.0102827440056303 no 51 0.00698104812401595 125 5705015
SGTC_1094 duloxetine 25.4 µM 2.45634713098112 0.0103301764701116 no 52 0.00701787521147595 132 60834 A selective serotonin reuptake inhibitor.
SGTC_2011 4012611 177 µM 2.45550080142529 0.0103514785720923 no 53 0.0070344219527857 143 2049887
SGTC_2366 9070441 60.58 µM 2.43985431387978 0.0107522562452243 no 54 0.00734659304105707 142 6837235
SGTC_464 bw-b 70c 158 µM 2.4333746483464 0.0109221456104432 no 55 0.00747940698243825 152 5353454
SGTC_3351 9150312 21.596 µM 2.42421965398379 0.0111661584564978 no 56 0.00767066159988947 132 4904905
SGTC_2005 4024620 188 µM 2.41806203501447 0.0113329346623308 no 57 0.00780170821549882 120 236743
SGTC_2882 9058044 58.44 µM 2.41280492011174 0.0114770299064042 no 58 0.00791514494692829 110 18076804
SGTC_452 diindolylmethane 8 µM 2.40174812959191 0.0117852933636188 no 59 0.00815846941270501 91 3071 Inhibits expression of several cancer promoting factors.
SGTC_1173 0443-0020 122 µM 2.39859809558985 0.0118744209848739 no 60 0.00822898377968484 166 5331295
SGTC_2475 5812728 15.03 µM 2.39176747322355 0.0120696986854578 no 61 0.00838373076974939 136 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1697 st025554 27.742 µM 2.36000527611297 0.013014737237545 no 62 0.00913733757402241 113 1269519
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.35928204117823 0.0130369807431532 no 63 0.00915516675654036 131 16623 A steroid.
SGTC_3210 9128157 49.47 µM 2.35646736833789 0.0131238607248294 no 64 0.00922484427537627 195 17590849
SGTC_3134 9127454 49.47 µM 2.3518536450837 0.0132673540381327 no 65 0.00934006159800292 99 24262820
SGTC_1363 1636-0063 10.4 µM 2.34705877920084 0.013417915330521 no 66 0.00946113470666867 158 6072185
SGTC_830 4076-0286 57.8 µM 2.33991488209204 0.0136449731895264 no 67 0.00964406761710485 278 6866659
SGTC_1134 3477-0009 42.5 µM 2.3329952999597 0.0138680547891433 no 68 0.00982419599869496 183 3973534
SGTC_1594 piperine 70.1 µM 2.32167231045771 0.014239883326594 no 69 0.0101252935028884 151 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2865 9030313 51.95 µM 2.30376445092288 0.0148454758351177 no 70 0.010617934837863 114 42562754
SGTC_293 4049-0273 38.5 µM 2.29895094556533 0.0150119832377742 no 71 0.0107538625001166 102 1380311
SGTC_1911 st060208 74.3 µM 2.29512877339596 0.0151453396919373 no 72 0.0108628727793375 161 688783
SGTC_968 1309-0633 340 µM 2.29359464651565 0.0151991512866338 no 73 0.0109068965947766 127 3761976
SGTC_740 k014-0057 261 µM 2.27188514340895 0.0159784263352754 no 74 0.0115467242274236 172 4012779
SGTC_2495 cafestol 54.53 µM 2.27029123211797 0.0160369667126916 no 75 0.0115949593449229 168 16667697 An anti-infammatory.
SGTC_965 1291-5240 308 µM 2.26109702563316 0.0163782474841629 no 76 0.0118766247662346 163 2834598
SGTC_1502 4534-4282 27.7 µM 2.25578271592384 0.0165783319076511 no 77 0.0120421211548485 133 3278949
SGTC_1328 1441-0025 69.2 µM 2.24990327857665 0.0168021273320584 no 78 0.0122275428934075 121 4562601
SGTC_2354 9060492 162 µM 2.24559891471064 0.0169676028866075 no 79 0.0123648550348035 165 6471895
SGTC_1280 0880-0253 10.1 µM 2.21485505237289 0.0181905102385019 no 80 0.0133850075425464 164 6836607
SGTC_3003 9075612 71.4286 µM 2.21429661920448 0.0182134002541542 no 81 0.0134041905220176 168 6501993
SGTC_777 1315-0167 517 µM 2.20544467153629 0.0185795301684256 no 82 0.0137114531355489 162 4221767
SGTC_3208 9114115 49.47 µM 2.20365725407905 0.018654215945788 no 83 0.0137742287443141 198 650895
SGTC_976 1348-1067 47.6 µM 2.18740553127107 0.0193450820986575 no 84 0.014356466373281 195 5310671 YGL099W LSG1
SGTC_450 aminopyrene 156 nM 2.18543207782375 0.0194304362451509 no 85 0.0144285905126124 198 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_923 1900-2434 73.3 µM 2.17160412812551 0.0200375316397444 no 86 0.0149427676913269 196 5910570
SGTC_1669 st015249 58.4 µM 2.16709708762767 0.0202388515392793 no 87 0.0151137259767472 132 722793
SGTC_3295 9122362 53.5725 µM 2.16193352561548 0.0204716021172305 no 88 0.0153116501981345 153 4730473
SGTC_631 k072-0230 41.5 µM 2.15967184045273 0.020574260955311 no 89 0.0153990413109047 175 5773147
SGTC_725 1497-0963 19 µM 2.1583640533372 0.0206338207142616 no 90 0.0154497691189941 149 3549977
SGTC_2131 toluylene red 5.2905 µM 2.15763244393216 0.020667203615796 no 91 0.0154782100716005 207 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_914 3820-6779 408 µM 2.1550891589504 0.0207836083141062 no 92 0.0155774289519035 177 2893481
SGTC_1085 doxorubicin 7.67 µM 2.1541854778584 0.0208251027292046 no 93 0.0156128146286868 202 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1358 1509-0022 2.48 µM 2.14821405520491 0.0211010597988223 no 94 0.015848377328016 165 3258434
SGTC_297 0986-0032 24 µM 2.14624590910797 0.0211926888846699 no 95 0.0159266822970538 138 2847425
SGTC_2053 5265679 138 µM 2.12137011844241 0.0223801108837497 no 96 0.0169453339282632 221 764595
SGTC_1298 1079-1278 263 µM 2.12098784645864 0.0223987873890695 no 97 0.0169614126007724 179 2840950
SGTC_570 0987-0065 62.6 µM 2.10603319956363 0.0231398047707452 no 98 0.0176007342981967 121 3104428
SGTC_2380 9035439 200 µM 2.10504485419366 0.0231894970265336 no 99 0.0176437019054059 212 6462575
SGTC_2370 9071495 200 µM 2.10457260040952 0.0232132728119402 no 100 0.0176642643869045 212 21791103
SGTC_958 1222-0007 33 µM 2.10424373424122 0.0232298418148154 no 101 0.0176785956803568 216 7312461
SGTC_1146 3579-1023 7 µM 2.10369955893127 0.0232572804326829 no 102 0.0177023314842308 211 X1146
SGTC_630 4356-0227 183 µM 2.09546397191312 0.0236758800562346 no 103 0.0180648839609236 151 779312
SGTC_2688 kanamycin b 96.69 µM 2.08655825691467 0.024135652857266 no 104 0.0184640419715487 765 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_944 3370-0224 231 µM 2.08384073774355 0.0242774341982986 no 105 0.0185873281983107 200 4580514
SGTC_311 1315-0136 58 µM 2.07672681204483 0.0246519049761151 no 106 0.018913390247943 162 6759207
SGTC_3318 9139014 38.6185 µM 2.06960582230222 0.025031589202691 no 107 0.0192446361974108 171 16643984
SGTC_2423 st077119 87.2 µM 2.06211875104399 0.0254360671386121 no 108 0.0195982157791982 196 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1629 st005085 44.9 µM 2.06172582093618 0.0254574449219655 no 109 0.0196169234096151 232 24207091
SGTC_2969 9091408 28.7 µM 2.06119139059348 0.0254865453269726 no 110 0.0196423922844886 233 4286311
SGTC_1464 k208-0027 110 µM 2.06062352906898 0.0255174966229464 no 111 0.0196694851201322 189 X1464
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.04874682797813 0.0261720842008977 no 112 0.0202434387901105 218 5355888
SGTC_633 0437-0093 97.7 µM 2.04726637585577 0.0262546553649231 no 113 0.0203159687013754 169 2831118
SGTC_371 0195-0006 7.36 µM 2.04568144361977 0.0263432951055169 no 114 0.0203938613049711 174 3928593
SGTC_133 0724-0033 378.92 µM 2.03695757923732 0.0268356795049191 no 115 0.020827146611465 187 280309
SGTC_1578 josamycin 24.2 µM 2.03680289651912 0.02684447882929 no 116 0.0208348989687105 189 5282165 A P450 substrate.
SGTC_832 4083-0019 164 µM 2.02955773126276 0.0272593363833845 no 117 0.0212007575580516 400 1990758
SGTC_1505 k297-0037 20.6 µM 2.02826407456092 0.0273339709013913 no 118 0.0212666517364732 216 4089396
SGTC_393 acivicin 6.25 µM 2.02635195840265 0.0274445980646255 no 119 0.0213643651544064 189 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1250 0485-0349 40.2 µM 2.02344629609907 0.0276134222503336 no 120 0.0215135775777084 222 6842794 YDL195W SEC31
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.01972789272813 0.0278307299652243 no 121 0.0217058101030469 225 5106787 A p450 inhibitor.
SGTC_2037 5169046 200 µM 2.01043219795363 0.0283802204870538 no 122 0.0221927327798151 190 5718022
SGTC_77 0828-0286 12.516 µM 2.00514644544911 0.02869668002501 no 123 0.0224736967071129 258 745345
SGTC_2447 5741742 33.78 µM 2.00432254800212 0.0287462703546881 no 124 0.0225177600150084 231 1776504
SGTC_2449 5812982 45.77 µM 1.99503187053382 0.0293104237741834 no 125 0.023019701994668 163 776185
SGTC_2302 7771753 200 µM 1.96602542278416 0.031131224346763 no 126 0.0246478370070713 286 2203047
SGTC_2653 dihydrofissinolide 100 µM 1.96239526459555 0.0313655490546065 no 127 0.0248582418300403 164 6857746
SGTC_1414 3917-0015 5.4 µM 1.95916194179886 0.0315754844353619 no 128 0.025046912301788 186 6618702
SGTC_1070 indatraline 8.81 µM 1.94762247180418 0.0323342163151874 no 129 0.0257300764356078 248 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_204 PMA1.184 62.41 µM 1.94647329409766 0.0324105928121586 no 130 0.0257989564327693 250 2252213 YGL008C PMA1
SGTC_511 blebbistatin 171 µM 1.92620555558061 0.0337822641018681 no 131 0.0270393562066725 237 3476986 A myosin inhibitor.
SGTC_850 0388-0143 75.9 µM 1.92434738414032 0.0339103759611815 no 132 0.0271555274455748 218 67273
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.9241636614567 0.0339230644244203 no 133 0.027167036214713 235 4330530
SGTC_1372 2752-0194 270 µM 1.92336325764589 0.0339783883884739 no 134 0.0272172226601275 216 823334
SGTC_3007 9078383 71.4286 µM 1.91614819131068 0.0344804509117482 no 135 0.0276731178498844 237 6496995
SGTC_2956 9076196 2.52 µM 1.91460604863859 0.0345885481288598 no 136 0.0277713815860497 248 16423868
SGTC_1836 st055642 81 µM 1.90442391408511 0.0353092755786082 no 137 0.0284274985785187 272 8571
SGTC_2356 9061756 188.97 µM 1.88980341015188 0.0363656647587417 no 138 0.0293921286604424 194 20104043
SGTC_2528 xanthyletin 44.79 µM 1.88288393897247 0.0368745674830605 no 139 0.0298580491366841 234 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1509 1326-1131 80 µM 1.87949667886261 0.037125803241247 no 140 0.0300883532892456 213 768313
SGTC_237 nikkomycin 200 µM 1.87871030505043 0.0371843288418368 no 141 0.0301420299794386 262 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1788 fluconazole 20 µM 1.87424169805796 0.0375183363555072 no 142 0.0304485596258928 283 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3121 9125696 49.47 µM 1.8615441609997 0.0384808083642092 no 143 0.0313336851857551 191 1235365
SGTC_562 3772-2733 112 µM 1.86104135310344 0.0385193315731881 no 144 0.0313691685619355 337 2876874 YIL048W NEO1
SGTC_441 propafenone 146 µM 1.86034923301222 0.0385724105582245 no 145 0.0314180661226418 194 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1144 3486-0183 12.5 µM 1.85550263551024 0.0389457703411095 no 146 0.0317622416116209 291 6744069
SGTC_723 4182-0001 115 µM 1.84911098468819 0.039442648048461 no 147 0.0322208942774075 258 744821 YLR208W SEC13
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.84457897707897 0.0397980749473941 no 148 0.0325494037388324 273 6312947
SGTC_2996 9066192 71.4286 µM 1.82871405630839 0.0410628566379493 no 149 0.0337212278134982 304 6472854
SGTC_1564 D-Arginine 115 µM 1.82441242189236 0.0414113520128874 no 150 0.0340448727245038 293 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3275 9138069 49.47 µM 1.8199349240337 0.0417766368763806 no 151 0.034384457836448 229 17617007
SGTC_2855 9016525 58.44 µM 1.81730834749701 0.0419921307249617 no 152 0.0345849562598084 280 43811474
SGTC_1724 st037281 8.293 µM 1.8168281089304 0.0420316283686111 no 153 0.034621718675484 312 574124 YDL195W SEC31
SGTC_727 3032-0951 202 µM 1.81157181783608 0.0424659054405344 no 154 0.0350261913954449 268 3652836
SGTC_1819 st053448 58.6 µM 1.80933627287802 0.0426517037564608 no 155 0.0351993885075737 265 2857616
SGTC_1007 4101-0031 70 µM 1.78778155641907 0.0444770536311391 no 156 0.0369056288112113 295 1146276
SGTC_374 0880-0231 82.3 µM 1.78678922770558 0.044562580990128 no 157 0.0369857805391226 307 6833587
SGTC_2486 5283202 22.39 µM 1.78305287577362 0.04488580090264 no 158 0.0372888482209572 295 1377751
SGTC_3206 9114350 49.47 µM 1.7818213035742 0.044992752944994 no 159 0.0373891885258978 283 17087243
SGTC_1210 3013-0140 750 nM 1.78050156511465 0.0451075890856555 no 160 0.0374969567077792 268 905973
SGTC_3056 9094900 49.47 µM 1.77513957620458 0.0455765868811469 no 161 0.0379374218522122 311 25236784
SGTC_2470 5664817 21.68 µM 1.76817701924239 0.0461914238114261 no 162 0.0385156573899434 253 2859561
SGTC_657 3534-0529 86.7 µM 1.76346043806562 0.0466116988526793 no 163 0.0389114320575323 298 1049549
SGTC_3028 9087778 49.47 µM 1.76041143769775 0.0468850117910293 no 164 0.0391690357234005 267 17217395
SGTC_1101 ebselen 5.29 µM 1.742600505682 0.0485073669789568 no 165 0.0407017108236861 313 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1670 st016595 4.04 µM 1.74139755684505 0.0486185392822341 no 166 0.0408069580861658 302 597879
SGTC_890 0929-0006 47.2 µM 1.74110557588424 0.0486455538341267 no 167 0.0408325370825955 265 1378169
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.73540394429981 0.0491754869765788 no 168 0.0413346409749968 297 5282362
SGTC_981 1488-1094 54.9 µM 1.72593532516414 0.0500657153657565 no 169 0.0421795243404286 250 3449522
SGTC_3154 9100113 49.47 µM 1.72553010803954 0.0501040982565543 no 170 0.042215991342882 312 25237525
SGTC_1388 3346-4487 254 µM 1.72307625282263 0.0503370332558266 no 171 0.0424373682824567 342 3345614
SGTC_1953 st076800 12.1 µM 1.71877615984798 0.0507473049679462 no 172 0.0428275690509724 364 297591
SGTC_1733 st037357 54.9 µM 1.71870980839687 0.0507536563564239 no 173 0.0428336125815597 355 1272339 YGL099W LSG1
SGTC_590 k048-0076 22.4 µM 1.71498074419454 0.0511116338263229 no 174 0.0431743786893146 303 6832814
SGTC_677 0929-0063 136 µM 1.71481164240249 0.0511279145251343 no 175 0.0431898831511933 238 1539583
SGTC_3122 9126309 49.47 µM 1.71085962632397 0.0515095813151383 no 176 0.0435535146167128 274 17591206
SGTC_580 1123-0028 41 µM 1.70809890084327 0.0517775405736201 no 177 0.0438089964183005 384 1677248 YPR107C YTH1
SGTC_264 promethazine 12.5 mM 1.70669239676825 0.0519144829010834 no 178 0.0439396205792159 447 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.70529435374864 0.052050886485586 no 179 0.0440697700569637 356 5379071
SGTC_2472 5377652 49.4 µM 1.70328278283053 0.0522476498461509 no 180 0.0442575805188863 383 1610903
SGTC_1093 fluphenazine 7.97 µM 1.70056842878867 0.0525140922443765 no 181 0.0445120283800438 363 6602611 An atypical antipsychotic.
SGTC_2931 9014674 55.67 µM 1.70025106047579 0.0525453155798141 no 182 0.0445418557907959 332 2996810
SGTC_407 eburnamonine 100 µM 1.69941390101646 0.0526277477171322 no 183 0.0446206122941014 277 3195
SGTC_913 3487-1245 167 µM 1.69523458291477 0.0530408065111226 no 184 0.0450154644567793 337 4016153
SGTC_835 0312-0010 67.2 µM 1.68428212407611 0.0541354839536356 no 185 0.0460635792083483 291 1626196
SGTC_1798 st045719 60.953 µM 1.68120304310452 0.0544464307643906 no 186 0.0463617413191649 268 3980186
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.68099558941588 0.0544674315595315 no 187 0.0463818856347169 353 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1015 4130-4525 82 µM 1.67768194162682 0.054803745462773 no 188 0.0467046033089732 331 1363237
SGTC_87 0100-0052 35.5 µM 1.67446385370826 0.0551319297210639 no 189 0.0470197362914654 578 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1750 st081859 2.357 µM 1.67126675624687 0.0554595088020787 no 190 0.0473344998352576 570 5291695
SGTC_1286 0929-0070 131 µM 1.66282364996198 0.0563319912669041 no 191 0.0481738705479083 364 1420408
SGTC_1400 3771-8998 51.5 µM 1.66229942617281 0.0563865175492239 no 192 0.0482263764048825 291 670767
SGTC_1723 st034307 2.5525 µM 1.65919271044359 0.0567105117753417 no 193 0.0485384830166 343 867466
SGTC_1621 st003705 32.4 µM 1.65538723281734 0.0571093750555376 no 194 0.0489229870519858 386 24207032
SGTC_292 k038-0015 474 µM 1.65209770594443 0.0574559365826533 no 195 0.0492573172753583 328 46368540
SGTC_2821 7996764 71.43 µM 1.64559956900391 0.0581453951265344 no 196 0.0499231139737674 392 2987135
SGTC_1555 citronellol 128 µM 1.64464163766062 0.0582475800531728 no 197 0.0500218674633772 287 8842 A terpine precursor.
SGTC_211 3455-0679 143.504 µM 1.6434313389426 0.0583768872924738 no 198 0.0501468602546491 379 748649
SGTC_622 1348-1566 26.3 µM 1.64174909854786 0.0585569906912134 no 199 0.0503210059199591 381 7340407
SGTC_1838 st055369 84.5 µM 1.63969371211648 0.0587776355302805 no 200 0.0505344334961185 311 676036
SGTC_1393 3470-5649 58.2 µM 1.63510785351373 0.0592722772142441 no 201 0.0510132200587639 275 4108395
SGTC_1291 0993-0025 5.79 µM 1.6348586781008 0.0592992470827246 no 202 0.051039338286452 337 4353356
SGTC_1934 st074720 32.6 µM 1.63461319264793 0.0593258269714754 no 203 0.0510650801441744 419 17250992
SGTC_2247 cerulenin 830 nM 1.62876919789333 0.0599613465249334 no 204 0.0516809438174139 362 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1074 carmofur 3.8 µM 1.61266238429389 0.0617405342052265 no 205 0.0534089385121608 420 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_816 0325-0417 81.3 µM 1.6111690951815 0.0619075515544636 no 206 0.0535714358896898 330 68101
SGTC_2134 5324836 1.464 µM 1.60597201419617 0.0624915708136657 no 207 0.0541400295426836 297 699272
SGTC_104 0074-0074 590.992 µM 1.60109908377405 0.0630430573258187 no 208 0.0546774875642399 229 3943124
SGTC_3335 9143315 29.6265 µM 1.59881808723408 0.0633025047207382 no 209 0.0549305144555101 354 4899691
SGTC_1904 st060225 78 µM 1.59690336835898 0.0635209316982206 no 210 0.0551436244291537 349 66595
SGTC_1314 1222-0010 41.1 µM 1.59677405157824 0.0635357049945953 no 211 0.0551580410186797 342 3526027
SGTC_32 0928-0142 34.1 µM 1.59076308482426 0.0642253598440274 no 212 0.0558314518108956 315 2244242
SGTC_1792 st045773 43.6 µM 1.58189507695088 0.0652534173484592 no 213 0.0568367625017777 381 2919270
SGTC_1156 4092-0367 4.88 µM 1.57996217057891 0.0654791824679327 no 214 0.0570577650175139 399 1357585
SGTC_1267 0828-0272 9.49 µM 1.57869318437635 0.0656277302316406 no 215 0.0572032244459846 418 745334
SGTC_809 3998-0021 90 µM 1.57369119840445 0.0662158095934471 no 216 0.0577794288173064 342 715485
SGTC_747 3448-8087 38.7 µM 1.57236745578831 0.0663721219021838 no 217 0.0579326786160261 423 5168703
SGTC_1435 4092-0789 56.7 µM 1.57116232396465 0.066514676546892 no 218 0.0580724744959886 364 2248285
SGTC_705 1124-0212 310 µM 1.56160760354467 0.0676533040973683 no 219 0.0591902285753613 403 9554485
SGTC_607 4491-0986 66.8 µM 1.55925609008277 0.067935827849368 no 220 0.0594678899930162 416 698981 YDR232W HEM1
SGTC_1236 0330-0013 258 µM 1.55486388567368 0.0684659704232838 no 221 0.0599892450141339 348 4617066
SGTC_2802 7925815 54.55 µM 1.55422218206222 0.0685436910448682 no 222 0.0600657140578582 425 1262923
SGTC_1190 1486-1332 13 µM 1.55188834149485 0.0688269305898552 no 223 0.0603444714847379 386 4150046
SGTC_3005 9076496 71.4286 µM 1.54897257196323 0.0691820610998151 no 224 0.0606941568234004 350 21368410
SGTC_1437 4092-1038 11.6 µM 1.54748647823887 0.0693636044456622 no 225 0.0608729912808147 406 3977136
SGTC_118 0083-0097 135.343 µM 1.54404734372382 0.0697851410890402 no 226 0.0612884318643784 644 5207356
SGTC_195 4234-0266 16.654 µM 1.54334691668537 0.0698712340048282 no 227 0.0613733129499849 450 2303354
SGTC_414 piperonyl butoxide 100 µM 1.54054062436414 0.0702169891016283 no 228 0.0617143141701734 361 5794 A potent inhibitor of cytochrome P450.
SGTC_724 3910-0327 137 µM 1.53824415795511 0.070500907820534 no 229 0.0619944638909814 416 2885483
SGTC_2336 9001819 198.65 µM 1.53687732488233 0.0706703117634779 no 230 0.0621616766108269 447 2989602
SGTC_882 0843-0131 351 µM 1.53506937149273 0.0708948680522996 no 231 0.0623833943991195 417 5425421
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.53438485525865 0.0709800310860028 no 232 0.0624675005917271 335 15053
SGTC_538 2922-0838 53.3 µM 1.53273067294559 0.0711861579969183 no 233 0.0626711141770612 479 777039
SGTC_2695 st077686 51.995 µM 1.53062406392502 0.0714493265665718 no 234 0.062931165438158 377 2876092
SGTC_2600 tangeritin 87.95 µM 1.5302391181503 0.0714974965800736 no 235 0.0629787759477754 380 68077 A bioactive flavone.
SGTC_209 4077-0173 175.592 µM 1.52814106889764 0.0717604731808159 no 236 0.0632387583138418 294 15993494
SGTC_906 1165-0455 526 µM 1.52244558416499 0.0724781052848973 no 237 0.0639487351763446 377 3252859
SGTC_1385 3091-4834 14.1 µM 1.51973232989115 0.0728219033233947 no 238 0.0642891313291537 384 4072814
SGTC_2652 actinonin 100 µM 1.51905798230495 0.0729075437122439 no 239 0.0643739509043638 348 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1247 0448-0043 5.84 µM 1.5189487195269 0.0729214270557144 no 240 0.0643877021810011 472 3089013 YGL099W LSG1
SGTC_1430 4049-0248 69.1 µM 1.51591932756184 0.0733071594989804 no 241 0.0647698762427116 454 22774488
SGTC_423 5-fluorouracil 457 µM 1.51581214877639 0.0733208351052056 no 242 0.0647834296141558 428 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2774 tamoxifen 10.92 µM 1.51321177513138 0.0736532312871329 no 243 0.0651129370804517 402 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2294 7971431 200 µM 1.50354264588751 0.0748993120646642 no 244 0.066349584207949 346 5741572
SGTC_2497 7-hydroxyflavone 100 µM 1.50191370445324 0.0751108107705906 no 245 0.0665596984258616 380 5281894
SGTC_2452 5863136 48.41 µM 1.4942484423625 0.0761121720728311 no 246 0.0675553476844647 429 2184096
SGTC_800 3448-7362 155 µM 1.49360858009909 0.0761962186787708 no 247 0.0676389777615597 708 15991913
SGTC_1656 st012921 11 µM 1.49053763867066 0.0766005735037665 no 248 0.0680414637619302 394 6732821
SGTC_3022 9087993 49.47 µM 1.49000576379351 0.0766707716637124 no 249 0.0681113602130969 358 17173644
SGTC_2779 methotrexate 400 µM 1.48912508771375 0.0767871130204434 no 250 0.0682272163025014 438 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1203 3992-3522 103 µM 1.48423947394216 0.0774349641103215 no 251 0.0688727005258925 463 5322312
SGTC_2403 6032726 181.2 µM 1.48260318938756 0.0776528671510175 no 252 0.0690899346342302 426 2881040
SGTC_2945 9067681 61.76 µM 1.47164921988262 0.0791236064210655 no 253 0.0705578134349336 391 16456930
SGTC_752 1896-0090 130 µM 1.46760447225799 0.0796719763389473 no 254 0.0711058462461618 433 772567
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.4667505939799 0.0797881082613797 no 255 0.071221957079771 429 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2136 5328288 199.296 µM 1.46656722843201 0.0798130636286793 no 256 0.0712469102025882 355 262395
SGTC_644 1498-1197 63.3 µM 1.46599892012892 0.0798904457717721 no 257 0.0713242905248478 475 6741615
SGTC_1761 st044296 37 µM 1.46280915392313 0.0803258247979298 no 258 0.0717598037935322 436 1826700
SGTC_3159 9100096 49.47 µM 1.4599053949037 0.0807237228549851 no 259 0.0721580381686717 435 25236875
SGTC_1155 4088-0394 48.2 µM 1.45353826501888 0.0816014091978981 no 260 0.0730371817201993 463 2326248
SGTC_2830 7992007 71.43 µM 1.4484511655884 0.0823078035940606 no 261 0.0737454570609158 426 1952075
SGTC_891 0929-0073 133 µM 1.44450686228807 0.0828586713441647 no 262 0.0742982254129138 436 5603632
SGTC_2706 st078239 82.5 µM 1.44208180669952 0.0831987327648852 no 263 0.0746396484172437 436 15434492
SGTC_1160 4092-0570 10.5 µM 1.44007540946218 0.0834808788472768 no 264 0.0749230326936036 483 4994975
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.43869003161324 0.0836761144389582 no 265 0.0751191824520054 408 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_444 curcumin 90.4 µM 1.43661007897961 0.0839698774251433 no 266 0.0754144090583321 478 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3193 9111931 49.47 µM 1.43655304923375 0.0839779429392206 no 267 0.075422516247022 459 17087244
SGTC_2304 7443016 91.4 µM 1.43650015133925 0.0839854246202754 no 268 0.0754300366570906 404 939854
SGTC_2993 9054257 71.4286 µM 1.43537739584902 0.0841443410433061 no 269 0.075589791857117 493 6470217 YGL055W OLE1
SGTC_497 capsazepine 133 µM 1.43528185431368 0.084157874543692 no 270 0.0756033982123328 435 2733484 A calcium channel blocker.
SGTC_1351 1496-0003 46.5 µM 1.4307920152069 0.0847957063364494 no 271 0.0762449161013998 474 3891978
SGTC_3243 9134147 49.47 µM 1.42989253506517 0.0849239222266092 no 272 0.076373932428906 432 24282180
SGTC_3191 9110352 49.47 µM 1.42628472998825 0.0854396555414333 no 273 0.0768930852609196 416 17122424
SGTC_2777 climbazole 1.536 µM 1.42336266300649 0.0858590795863743 no 274 0.0773155251091198 501 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_599 1935-0052 86.5 µM 1.42078408514011 0.0862304785811006 no 275 0.0776897693821843 485 9557311
SGTC_581 0958-0271 211 µM 1.42016452771816 0.0863198937611398 no 276 0.077779893989909 574 4591145
SGTC_23 0213-0011 39.996 µM 1.41412356419072 0.0871953688702099 no 277 0.0786628127386458 471 627608
SGTC_3102 9121669 49.47 µM 1.41300503665976 0.0873581942590192 no 278 0.0788271215901969 408 41905072
SGTC_2903 5923464 63.88 µM 1.41265373498251 0.0874093804729352 no 279 0.0788787805353722 435 2876576
SGTC_1951 sophoraflavanone G 9.2 µM 1.40925520247547 0.0879057180907899 no 280 0.0793798599942464 525 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2249 haloperidol 116.36 µM 1.40804198349357 0.0880834104320459 no 281 0.079559319308328 610 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2348 9022543 33.42 µM 1.40802753051248 0.0880855288796561 no 282 0.0795614590416936 494 3162678 YDL140C RPO21
SGTC_336 4111-0029 111 µM 1.40707886849776 0.0882246622270196 no 283 0.0797020017034622 398 3131175
SGTC_2513 baicalein 25.65 µM 1.4033484975137 0.0887733572402969 no 284 0.0802564714534761 470 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1487 3970-0795 2.82 µM 1.40284649945146 0.0888473889952374 no 285 0.0803313087547971 487 3765103
SGTC_1449 4112-4002 201 µM 1.40073758844875 0.0891589011608916 no 286 0.080646278995109 467 2059539
SGTC_2484 5809818 12.04 µM 1.39664226534749 0.0897661513339704 no 287 0.0812605868985646 467 2870548
SGTC_2496 diffractaic acid 79.83 µM 1.39145621813322 0.0905395379516877 no 288 0.0820435636078001 515 94870 An apoptosis inducer which activates caspases.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.38983744668027 0.0907819527481215 no 289 0.0822891220666971 458 6708514
SGTC_3204 9114183 49.47 µM 1.38978032319292 0.0907905159128414 no 290 0.0822977974756634 479 17027248
SGTC_1172 0370-0043 85 µM 1.38770630940007 0.0911018295137341 no 291 0.0826132469968946 453 376585
SGTC_3254 9136651 49.47 µM 1.38610221940867 0.0913431490332206 no 292 0.0828578463889316 510 16454030
SGTC_232 clozapine 119 µM 1.38608021959573 0.0913464619791363 no 293 0.0828612048101328 481 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2924 9010168 62.78 µM 1.38573523934758 0.0913984241127823 no 294 0.0829138817885387 507 2993929
SGTC_1269 0831-0796 3.05 µM 1.38455800356078 0.0915759084516441 no 295 0.0830938302265225 485 927758
SGTC_3228 9131799 49.47 µM 1.38207634530928 0.0919508887031242 no 296 0.0834741303593452 478 17015818
SGTC_2095 5432005 200 µM 1.38152088787992 0.0920349742178035 no 297 0.0835594299573201 438 783734
SGTC_1103 duloxetine 36.1 µM 1.37108585444635 0.0936252341087769 no 298 0.0851740970221828 558 60835 A selective serotonin reuptake inhibitor.
SGTC_679 0422-0091 41.4 µM 1.36952606829779 0.0938646722691168 no 299 0.0854174459544129 537 627384 YHR062C RPP1
SGTC_624 k048-0052 28 µM 1.36748094368322 0.0941792976940789 no 300 0.0857373031712356 480 6835531
SGTC_1304 1165-0502 251 µM 1.36455639202612 0.0946305663640549 no 301 0.0861962593540603 564 767425
SGTC_995 3931-2021 34.6 µM 1.36424751423128 0.0946783201997832 no 302 0.0862448393013261 480 730143
SGTC_2020 4017018 200 µM 1.35973556107897 0.0953779134423272 no 303 0.086956810264092 506 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_258 haloperidol 50.781 µM 1.35828646527736 0.0956034059152903 no 304 0.0871864016462836 510 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1205 4161-2785 76 µM 1.35604430271991 0.0959530794895359 no 305 0.0875425362678873 446 3498106
SGTC_560 2332-1943 155 µM 1.35484271603177 0.0961408580385589 no 306 0.0877338368972018 503 21177716
SGTC_877 0771-0151 33.1 µM 1.35183410703439 0.0966122147087811 no 307 0.0882141952896139 552 6166523
SGTC_3196 9111891 49.47 µM 1.35183263767019 0.0966124453270366 no 308 0.0882144303681853 465 18891510
SGTC_2557 derrustone 83.84 µM 1.34929553974081 0.0970112489098559 no 309 0.0886210288503804 561 629853 An antioxidant.
SGTC_2100 5377183 190 µM 1.34758159681815 0.0972813447534475 no 310 0.0888964964672827 551 2844202
SGTC_2792 7535235 81.82 µM 1.34514895362319 0.097665645422013 no 311 0.0892885685156499 480 1281891
SGTC_1391 3442-0225 151 µM 1.33616771237916 0.0990941123104969 no 312 0.0907472309277274 456 5227075
SGTC_1226 3909-7979 35.4 µM 1.33560043421692 0.0991848483296707 no 313 0.0908399540727534 584 6615510
SGTC_2818 7996756 12.99 µM 1.33437125673669 0.099381663421818 no 314 0.0910411075975844 412 2241621
SGTC_2705 st078069 42.8 µM 1.33323589679404 0.0995637100163886 no 315 0.0912272013380339 491 1530061
SGTC_2643 anethole 100 µM 1.33212658220154 0.0997418156912695 no 316 0.0914092983327078 535 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3118 9124250 49.47 µM 1.32847565058311 0.100329633424592 no 317 0.0920105111733917 474 1504786
SGTC_1610 st001799 48.1 µM 1.32766266166223 0.100460872075616 no 318 0.0921447868705928 448 621897
SGTC_2591 skatole 100 µM 1.32682052296498 0.100596948327613 no 319 0.0922840299378643 507 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_306 1672-3436 11.6 µM 1.32479291772467 0.100925128638834 no 320 0.0926199222328123 543 6797378
SGTC_765 1319-0117 244 µM 1.32411089008182 0.101035694229422 no 321 0.0927331096775719 483 3487746 YGL099W LSG1
SGTC_3097 9117246 49.47 µM 1.32319234136665 0.101184742467224 no 322 0.0928857111296407 517 16423892
SGTC_3239 9133757 49.47 µM 1.32252428500663 0.101293245182267 no 323 0.0929968140479391 499 17036923
SGTC_593 1203-0218 61.7 µM 1.32010144202232 0.101687463657377 no 324 0.0934005756961246 544 3666956
SGTC_1390 3413-2614 145 µM 1.31926513277758 0.101823797740642 no 325 0.093540245061498 560 3421432
SGTC_2137 5261020 140 µM 1.31850918992456 0.101947145039316 no 326 0.0936666253588641 511 763655
SGTC_1864 st057645 30.4 µM 1.31799862802079 0.10203051499586 no 327 0.0937520535951541 482 688666
SGTC_2109 5483026 200 µM 1.31696641922012 0.102199216494527 no 328 0.0939249404999546 555 759335
SGTC_84 0443-0269 128.823 µM 1.31395334667796 0.102692825607688 no 329 0.094430952308724 539 6150058
SGTC_1791 st048313 56.1 µM 1.3125126783961 0.10292945087233 no 330 0.0946736055482545 482 1204976
SGTC_2242 6630449 61.2675 µM 1.31177195866063 0.103051265848691 no 331 0.0947985444810471 459 691249 YDR170C SEC7
SGTC_3241 9133421 49.47 µM 1.30966748181604 0.103397928643916 no 332 0.0951541744197302 463 17018221
SGTC_2115 tiliquinol 12.7705 µM 1.30947397273713 0.103429847136093 no 333 0.0951869242622601 499 71208 A bioactive hydroxyquinoline.
SGTC_2943 9068529 45.32 µM 1.30935467359901 0.103449528580422 no 334 0.0952071188096547 577 3270634
SGTC_1865 st057639 52.2 µM 1.30835732262104 0.103614173500315 no 335 0.0953760704000523 540 688818
SGTC_1722 st034304 3.6505 µM 1.30572886861387 0.104048995233777 no 336 0.0958223885177591 566 4036148 YLR033W RSC58
SGTC_795 0685-0265 78 µM 1.30402157837237 0.104332137936476 no 337 0.096113112591229 552 302754
SGTC_412 gemfibrozil 100 µM 1.29991061747766 0.105016203478992 no 338 0.0968158028325485 465 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3001 9076041 71.4286 µM 1.29851360502901 0.105249404387743 no 339 0.097055452164484 535 16004211
SGTC_170 4197-0004 226 µM 1.29420293223754 0.105971338969947 no 340 0.0977976671094055 485 218692
SGTC_2310 7668677 200 µM 1.2921758548388 0.106312060235068 no 341 0.0981481256831973 546 2197143
SGTC_1990 st072050 59.8 µM 1.29216542390811 0.106313815561519 no 342 0.0981499314484835 557 17233948
SGTC_1581 himbacine 57.9 µM 1.27767741067807 0.108772114891677 no 343 0.100681596653252 576 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1064 honokiol 6.76 µM 1.26791632921319 0.110451241034 no 344 0.102413916032474 578 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_527 4476-4215 268 µM 1.26755205068186 0.110514262883809 no 345 0.102478982235063 580 4418754
SGTC_3120 9124077 49.47 µM 1.26328439391415 0.111254507618049 no 346 0.103243496338926 568 18774327 YGL155W CDC43
SGTC_2612 dictamnine 15.46 µM 1.26266551638604 0.111362148797133 no 347 0.103354705860778 565 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1232 0279-0259 161 µM 1.26164272567457 0.111540205836999 no 348 0.103538687348424 580 1560000
SGTC_2806 7952793 58.44 µM 1.26048468355405 0.111742054514917 no 349 0.103747284877498 576 2972490
SGTC_2517 totarol 10 µM 1.25895382230139 0.112009287002028 no 350 0.104023505800792 522 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3267 9137951 49.47 µM 1.25865501579602 0.112061500962688 no 351 0.104077483091244 505 16643986
SGTC_2078 5212016 200 µM 1.2573356726157 0.112292253280469 no 352 0.104316055929956 518 1899708
SGTC_567 1080-0542 68.4 µM 1.25546417207511 0.112620159722884 no 353 0.104655153195415 514 5950415
SGTC_1663 st014140 55.4 µM 1.25351707589865 0.112962036560721 no 354 0.105008794309193 661 4207120
SGTC_2838 9002687 71.43 µM 1.25126026214375 0.113359220615787 no 355 0.105419769213615 531 6457060
SGTC_2059 5238311 157 µM 1.25064503341425 0.113467669314329 no 356 0.105532006395636 582 703021
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.24989740694473 0.113599555821052 no 357 0.105668513396112 557 6708760
SGTC_1802 st050112 57.9 µM 1.24924898331275 0.113714030728174 no 358 0.10578701057192 585 4662563
SGTC_1608 st001473 40.5 µM 1.24798111153911 0.113938102636944 no 359 0.106018987226758 560 7292267
SGTC_1747 st037496 66.6 µM 1.24022718001708 0.115315307161407 no 360 0.107445688937491 617 723305
SGTC_2424 5537928 59.2 µM 1.23838874439387 0.115643566603443 no 361 0.107785976051378 641 5382802
SGTC_2105 5350118 200 µM 1.23487604319354 0.116272616956226 no 362 0.108438320353604 586 2133313
SGTC_263 alizarin 107.927 µM 1.23411989546755 0.116408343971568 no 363 0.108579115450928 677 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_345 1362-0200 395 µM 1.23406233979584 0.11641867970158 no 364 0.108589837729717 565 1419823
SGTC_1410 3909-8106 77.9 µM 1.2335674502961 0.116507577811988 no 365 0.10868206412563 577 1039210
SGTC_2194 5927483 104.545 µM 1.2242528577602 0.118189766700829 no 366 0.110428427385209 644 760979
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.22069824126982 0.118836226397601 no 367 0.111100146957309 693 91467 include heat shock
SGTC_3171 9103192 49.47 µM 1.21802301806165 0.119324399730841 no 368 0.111607612867965 585 13018434
SGTC_1501 4491-0275 38.4 µM 1.21680145388276 0.119547780133645 no 369 0.111839883370342 599 5104718
SGTC_2961 9083290 32.55 µM 1.21635917390133 0.11962873001696 no 370 0.111924064498444 562 17741490
SGTC_3074 9116018 49.47 µM 1.21511272361641 0.119857074047227 no 371 0.112161550710579 556 17027303
SGTC_1068 loratadine 26.9 µM 1.21396825051494 0.120067006775138 no 372 0.112379924195847 584 3957 A H1 histamine antagonist.
SGTC_1139 k015-0024 46.9 µM 1.21376613477631 0.120104108130309 no 373 0.112418520834215 605 2766652
SGTC_2968 9090663 33.37 µM 1.21359557192182 0.120135423768678 no 374 0.112451099405094 603 25236811
SGTC_1523 st012844 44.7 µM 1.21247066839481 0.120342102137235 no 375 0.112666131946821 618 4274103
SGTC_536 3852-0578 10.6 µM 1.21134351155199 0.120549445598524 no 376 0.112881889592505 621 2869208
SGTC_1442 4112-3290 3 µM 1.21133783981832 0.120550489564514 no 377 0.112882976007394 636 704353
SGTC_1956 st077085 54 µM 1.20623879510806 0.121491620565347 no 378 0.113862714662499 649 24208685
SGTC_1183 1254-0324 198 µM 1.20457885535206 0.121799107180762 no 379 0.114182961763988 628 5799357
SGTC_3274 9138298 49.47 µM 1.20242981783684 0.122198005656212 no 380 0.114598521163226 639 17015756
SGTC_3273 9137859 49.47 µM 1.20081425325716 0.122498485652387 no 381 0.114911630834437 599 2377234
SGTC_710 3448-4187 58 µM 1.19844884164746 0.122939364859118 no 382 0.115371163933639 725 3946412
SGTC_1168 k815-0004 80.5 µM 1.19792001885635 0.123038081907836 no 383 0.115474077749083 620 642433
SGTC_3099 9120367 49.47 µM 1.19676877992513 0.123253179497762 no 384 0.115698345052292 621 24824940
SGTC_2979 9012552 45.46 µM 1.19492091694469 0.123598985052242 no 385 0.116058964839359 566 17100905
SGTC_2292 7671323 168.05 µM 1.19322478883676 0.123916992760656 no 386 0.116390674436148 621 937504
SGTC_1558 st069300 45.6 µM 1.19081761463805 0.124369297151196 no 387 0.116862596145872 553 24208000
SGTC_625 k213-0058 121 µM 1.19004826309511 0.124514100307669 no 388 0.117013711607946 826 3655420
SGTC_253 dyclonine 31.25 µM 1.18960794829946 0.124597026974006 no 389 0.117100260192323 676 3180 An oral anasthetic.
SGTC_1439 4092-1168 46 µM 1.18764518519362 0.124967153460006 no 390 0.117486613974105 644 2886240
SGTC_1748 st037455 53.6035 µM 1.1873883038471 0.125015651435205 no 391 0.117537245668429 631 580690
SGTC_2123 5259487 200 µM 1.18643900217637 0.12519498912688 no 392 0.117724488455837 661 2173474
SGTC_3325 9138760 55.175 µM 1.18488002869318 0.125489892802577 no 393 0.118032442364529 623 43844959
SGTC_3130 9127414 49.47 µM 1.17799045194976 0.126798965531272 no 394 0.119400206363037 628 1494646
SGTC_456 gingerol 170 µM 1.17795564494383 0.126805603180135 no 395 0.119407144754025 630 442793 A herb.
SGTC_947 3447-0010 211 µM 1.17669130276352 0.127046875529869 no 396 0.119659370237166 639 748350
SGTC_140 0062-0056 502.533 µM 1.1741904839257 0.12752504316412 no 397 0.120159368393827 675 3758964
SGTC_1006 4099-6547 255 µM 1.17121185683416 0.128096200890193 no 398 0.120756815260514 644 3146833
SGTC_1983 st071813 46.9 µM 1.16631585131052 0.129038875775846 no 399 0.12174338331754 652 11838595
SGTC_3258 9138477 49.47 µM 1.16364154336073 0.129555812399604 no 400 0.122284654170569 646 4970355
SGTC_1106 tegaserod maleate 11.7 µM 1.16176628903022 0.129919148662797 no 401 0.122665205433013 681 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1731 st035964 63 µM 1.16062604982292 0.130140418053981 no 402 0.122897003493587 627 6739575
SGTC_1628 st004252 77.7 µM 1.15809936761042 0.130631662797522 no 403 0.12341174402737 670 692968
SGTC_693 4161-2696 114 µM 1.1577827171326 0.130693317168859 no 404 0.123476359009884 597 805759
SGTC_1419 3993-2473 62.6 µM 1.15778199743798 0.130693457322047 no 405 0.123476505896132 673 704026
SGTC_367 0335-0881 7.1 µM 1.15660625457517 0.130922560001943 no 406 0.123716632863504 673 23828853
SGTC_990 3985-0011 41.3 µM 1.15548625442008 0.131141058739889 no 407 0.123945679151902 601 5399565 YGL099W LSG1
SGTC_1651 st011928 86.1 µM 1.15328900561895 0.131570447388455 no 408 0.124395890639749 657 720198
SGTC_678 1218-2179 85.9 µM 1.15326509320851 0.131575125708137 no 409 0.124400796522663 601 6820081 YOR116C RPO31
SGTC_1014 4130-3005 69.3 µM 1.14905946300744 0.132399718376295 no 410 0.125265731074805 674 743608
SGTC_533 1222-0222 6.71 µM 1.14860895462753 0.132488259713059 no 411 0.125358631491206 711 3982874
SGTC_115 0527-0192 112.043 µM 1.14768703838368 0.132669577049119 no 412 0.12554889194535 757 4233931
SGTC_273 hydroxyurea 18.1 mM 1.14575967162262 0.133049192770683 no 413 0.125947302997587 730 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3305 9127027 53.8275 µM 1.14343409431602 0.133508234860009 no 414 0.12642920178893 663 41905295
SGTC_1643 st009866 20.2 µM 1.14266939024686 0.133659416299504 no 415 0.126587941647512 653 3156273 YOR207C RET1
SGTC_317 4495-0002 170 µM 1.1423674838978 0.133719135361917 no 416 0.126650650595291 615 15991618
SGTC_1078 idebenone 36.1 µM 1.14227758198317 0.133736922096179 no 417 0.126669328295702 717 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_78 0336-0123 156.75 µM 1.13708904820631 0.134766209210528 no 418 0.127750530874651 609 6765896
SGTC_1444 4112-3581 28 µM 1.13596453804201 0.134990001241134 no 419 0.127985703005268 677 2877249
SGTC_2332 7982454 138.89 µM 1.13303561351577 0.135574091056648 no 420 0.128599648981192 691 2981748
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.13229924809882 0.135721209958214 no 421 0.128754323062935 728 23847180
SGTC_1991 st073000 8.92 µM 1.12806402072943 0.136569491468199 no 422 0.129646441324911 738 4301969 YIL048W NEO1
SGTC_2710 st078562 53.7235 µM 1.12539199896754 0.137106537189041 no 423 0.130211480023526 679 17250908
SGTC_1088 bifonazole 369 nM 1.1210757550082 0.137977096917811 no 424 0.131127808911176 690 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_76 0433-0009 400.328 µM 1.12035764245125 0.138122300801167 no 425 0.131280693732212 605 2841569
SGTC_3113 9123498 49.47 µM 1.11949617405464 0.138296628973969 no 426 0.13146426109612 710 8897275
SGTC_2400 5203494 178.7 µM 1.11746089217459 0.138709087556445 no 427 0.131898655983809 636 6777674
SGTC_3276 9139060 49.47 µM 1.11628556660116 0.138947653581934 no 428 0.132149958899709 636 4870619
SGTC_3320 9137005 35.139 µM 1.11500846556111 0.139207194379408 no 429 0.132423397015082 655 4908713
SGTC_2682 pyrogallin 40.03 µM 1.1132708329365 0.13956085692537 no 430 0.132796064597887 740 822798 An ATP competetive kinase inhibitor.
SGTC_1769 st044406 64.4 µM 1.11300192715425 0.139615642205846 no 431 0.132853800906075 715 670903
SGTC_836 0330-0104 1.35 µM 1.11251391688808 0.139715103892043 no 432 0.132958624912595 697 46494820
SGTC_1863 st057641 20.1 µM 1.11156624719924 0.139908386638012 no 433 0.133162345811746 753 3921635
SGTC_2197 6588183 93.1375 µM 1.10762393655873 0.14071439367323 no 434 0.134012130721343 655 884136
SGTC_100 0086-0128 49.5915 µM 1.10555379522936 0.141138894235478 no 435 0.134459849006486 740 93297
SGTC_2775 cyproheptadine 69.59 µM 1.10504890795755 0.141242557359999 no 436 0.134569198718167 707 2913 A selective serotonin reuptake inhibitor.
SGTC_2692 st077426 47.7 µM 1.10417833185197 0.141421424685281 no 437 0.134757893544 724 25238571
SGTC_1721 st082152 9.2685 µM 1.10332079491827 0.141597763019421 no 438 0.13494393958468 645 5296051
SGTC_2635 hydroquinidine 100 µM 1.10306851344853 0.141649668891064 no 439 0.134998706575353 717 442912 An experimental heart treatment.
SGTC_3115 9123671 49.47 µM 1.10087807373431 0.142100884607311 no 440 0.135474863048426 735 3286988
SGTC_869 0564-0080 44.1 µM 1.100448555003 0.142189476510087 no 441 0.135568366369484 708 6843321
SGTC_143 4032-1194 15.74 µM 1.09960587779106 0.142363394454477 no 442 0.135751939939799 787 1806963
SGTC_1251 0490-5699 265 µM 1.09856732850825 0.142577935822513 no 443 0.135978417505758 757 3883818
SGTC_291 SEC14.278 35.5 µM 1.09703106726111 0.142895694227378 no 444 0.136313905754453 730 1068044
SGTC_2661 dactinomycin 12.96 µM 1.09492325115313 0.143332450629599 no 445 0.136775130853383 746 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1824 st053723 68.6 µM 1.09257965204569 0.143819120470736 no 446 0.137289200368434 702 675225
SGTC_2984 9022109 38.96 µM 1.09175560474708 0.143990506052132 no 447 0.137470268673743 680 6459207
SGTC_1371 2421-0008 32.7 µM 1.09142711373803 0.144058864085112 no 448 0.137542493590061 694 2827552
SGTC_1197 1601-0112 267 µM 1.090375904808 0.144277764689563 no 449 0.137773795671219 729 7350313
SGTC_2887 9044784 58.44 µM 1.08999571209168 0.144356990065692 no 450 0.137857516449337 776 6465546
SGTC_2274 7947094 46.08 µM 1.08831163728666 0.144708273734432 no 451 0.138228777419935 729 2971028
SGTC_1028 k015-0029 4.8 µM 1.0881445722578 0.14474315344179 no 452 0.138265644698355 719 4588309
SGTC_682 0kpi-0099 17 µM 1.08603461522101 0.145184155958496 no 453 0.138731838985602 752 1714895 YML126C ERG13
SGTC_473 2-arachidonoylglycerol 10 µM 1.08523986054992 0.145350501964961 no 454 0.138907717033036 696 5282280 An endocannabinoid.
SGTC_1868 st057644 42.7 µM 1.08484202389144 0.145433819242184 no 455 0.138995814700803 758 688665
SGTC_1807 st050092 58.9 µM 1.08442969816823 0.145520204796577 no 456 0.139087160986316 691 5008496
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.0843568608363 0.145535468388753 no 457 0.139103301551817 725 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2709 st078560 56 µM 1.08422934427562 0.145562193002898 no 458 0.139131561963495 743 17250903
SGTC_72 0744-0168 198.391 µM 1.0835717840359 0.145700055277698 no 459 0.139277353480089 695 677577
SGTC_1059 3448-6867 171 µM 1.07884467554032 0.146693711069585 no 460 0.140328487615208 742 3934407
SGTC_2468 5987765 72.9 µM 1.07755126252685 0.14696638173187 no 461 0.140617031099001 760 26772094
SGTC_1959 st077091 55.8 µM 1.0760291593676 0.147287698778772 no 462 0.14095710781174 742 821356 YKL052C ASK1
SGTC_2146 5545642 200 µM 1.07595761198992 0.147302814058077 no 463 0.140973107039227 727 825326
SGTC_895 0964-0006 13.7 µM 1.07493259957855 0.147519474899753 no 464 0.141202452719456 726 6738897
SGTC_1614 st002383 48.6 µM 1.07446443963272 0.14761850266834 no 465 0.141307287229954 728 1947235
SGTC_1649 st011737 51.3 µM 1.07372150726035 0.147775743189982 no 466 0.141473759480711 723 1761035
SGTC_1468 k284-1086 134 µM 1.07346759055582 0.147829509986262 no 467 0.141530686217282 783 15996457
SGTC_2200 6600604 21.907 µM 1.07216072950093 0.148106444644967 no 468 0.14182392280978 750 2904777
SGTC_689 0833-0039 98 µM 1.07136640324411 0.148274938473904 no 469 0.142002356523269 764 5374726
SGTC_1140 3229-1848 2.98 µM 1.07104955906144 0.148342183761045 no 470 0.142073573292506 749 2849525
SGTC_424 splitomicin 100 mM 1.06899822276866 0.148778041738519 no 471 0.142535235115668 686 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2446 5162541 200 µM 1.06373725899525 0.149899774625957 no 472 0.143723870344454 695 1549321
SGTC_1613 st002381 52.1 µM 1.06356070373608 0.149937516972773 no 473 0.143763875998678 734 551167
SGTC_2145 5634607 200 µM 1.06109549515105 0.150465168373253 no 474 0.144323252462255 671 308662
SGTC_37 0566-0070 1.56 µM 1.06074805611412 0.15053963330035 no 475 0.144402207075917 797 1626686
SGTC_2293 7624732 200 µM 1.05935151524736 0.150839194741138 no 476 0.144719860952455 669 894453
SGTC_1342 1486-1464 234 µM 1.05823047847916 0.151079946807754 no 477 0.144975189594476 775 3253938
SGTC_1833 st055984 71 µM 1.0581942470466 0.15108773207537 no 478 0.144983446763614 742 676288
SGTC_1530 rhein 70.4 µM 1.05802249481547 0.151124641150686 no 479 0.14502259352619 796 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1704 st028805 70.8 µM 1.0578589206356 0.151159798362497 no 480 0.145059882914233 719 2876101
SGTC_851 0394-0702 453 µM 1.05571402924207 0.151621306120178 no 481 0.145549442831772 805 762646
SGTC_3046 9092212 49.47 µM 1.05439346432734 0.151905912174593 no 482 0.145851406637147 741 25236637
SGTC_409 arachidonic acid 100 µM 1.05240387029644 0.152335376073674 no 483 0.146307146878509 747 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1526 st051518 75 µM 1.05056204535976 0.15273366097262 no 484 0.146729890309507 681 673993
SGTC_2390 9097792 176.6 µM 1.04706557316145 0.153491653123192 no 485 0.147534668025682 715 4497149
SGTC_131 0141-0277 33.849 µM 1.04555253615902 0.153820431960051 no 486 0.147883836425475 754 1547771
SGTC_190 3970-0790 3.722 µM 1.0426413119909 0.154454343426867 no 487 0.148557224133683 734 2832352
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.04142547434223 0.154719599426276 no 488 0.148839062353253 802 5393153
SGTC_2680 butyl paraben 22.24 µM 1.04129659976772 0.154747733274939 no 489 0.148868957157758 744 7184 An antifungal and steroid mimetic.
SGTC_3053 9095903 49.47 µM 1.04067565640945 0.154883335132589 no 490 0.149013052513914 774 17174018
SGTC_1974 st069448 26.9 µM 1.04065922230319 0.154886925085048 no 491 0.14901686745771 746 6323587 YNR016C ACC1
SGTC_3070 9117005 49.47 µM 1.03757446612769 0.155561748828655 no 492 0.149734105288459 711 8779016
SGTC_3112 9123419 49.47 µM 1.03736838904033 0.155606899425224 no 493 0.149782102278174 802 17015854
SGTC_2776 terbinafine 19.92 µM 1.03573133872876 0.155965877090732 no 494 0.15016374885006 731 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1653 st012112 65 µM 1.03321252802495 0.156519275248813 no 495 0.150752225660285 733 720429
SGTC_2904 7225135 42.03 µM 1.03148850141664 0.156898798863341 no 496 0.151155898831119 825 4446116
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.03139559437455 0.15691926840456 no 497 0.151177673004574 763 390807
SGTC_2951 9072950 58.06 µM 1.02836366626023 0.157588235550533 no 498 0.151889396510088 839 16488155
SGTC_1364 1653-0028 37.6 µM 1.025815776079 0.158151851039339 no 499 0.152489214194517 780 5718652
SGTC_2432 5630864 12.22 µM 1.02160473803368 0.159086266025619 no 500 0.153484007139406 755 5714970
SGTC_1701 st028638 40.4 µM 1.02133499363302 0.15914624440005 no 501 0.153547876258157 805 3490878
SGTC_1492 4158-0558 28.5 µM 1.02031405952697 0.159373385881835 no 502 0.153789768752458 778 3967268
SGTC_34 0469-0683 81.75 µM 1.01886338463118 0.159696502714154 no 503 0.154133914434376 784 3690923
SGTC_2141 5621638 7.665 µM 1.01812762949361 0.159860545239824 no 504 0.154308653234558 788 2856238
SGTC_2773 thioridazine 9.09 µM 1.01802632366256 0.159883140819884 no 505 0.154332723206196 803 5452 An antipsychotic.
SGTC_2778 tioconazole 65.09 nM 1.01701882536236 0.160107970188985 no 506 0.154572236993002 769 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1667 st014849 34.6 µM 1.01615384215596 0.160301161283859 no 507 0.154778066393554 815 5348460
SGTC_1708 st033234 31.827 µM 1.01490875855287 0.160579513896897 no 508 0.155074661376854 845 674664
SGTC_2405 ticlatone 3.52 µM 1.01471454023665 0.160622962060737 no 509 0.155120960498625 754 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1165 k072-0275 30.3 µM 1.01416678838339 0.160745539815524 no 510 0.155251586579629 777 6153523 YGL055W OLE1
SGTC_2144 5628481 200 µM 1.01187132969849 0.161259889466344 no 511 0.155799789565639 760 2818399
SGTC_3098 9119039 49.47 µM 1.01089008193218 0.161480087510978 no 512 0.156034520757352 789 17161528
SGTC_1336 1486-0901 104 µM 1.00561042510816 0.162668238670565 no 513 0.157301503523726 796 5006114
SGTC_588 3970-1144 52.9 µM 1.00541893571079 0.162711438670013 no 514 0.157347582832763 807 1888707
SGTC_867 0518-0118 155 µM 1.00057164643503 0.16380747188438 no 515 0.158516971764955 806 6848158
SGTC_2438 5259590 200 µM 1.00025522453607 0.163879185090665 no 516 0.158593504946482 844 1201127
SGTC_40 0327-0103 19.753 µM 0.999796665341572 0.163983148151812 no 517 0.158704459968215 767 409036
SGTC_2408 sulbentine 18.36 µM 0.999750696760271 0.163993572359546 no 518 0.158715585536494 787 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_290 2043-6722 48.1 µM 0.99815938750909 0.164354695563906 no 519 0.159101038149995 808 773758 YLR208W SEC13
SGTC_3008 9078912 71.4286 µM 0.998119537401789 0.164363745546049 no 520 0.159110698649654 776 16648731
SGTC_449 xestospongin c 11.1929 µM 0.997546363432921 0.164493949422626 no 521 0.159249690520665 824 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1901 st060216 58.6 µM 0.994625389170977 0.165158524599304 no 522 0.159959247227518 817 688792
SGTC_1215 3852-0577 11.2 µM 0.994065495607465 0.165286108863155 no 523 0.160095491137852 885 2884876
SGTC_2133 5320837 200 µM 0.993727019482958 0.16536326913876 no 524 0.160177892349231 747 2841355
SGTC_2002 4023503 131 µM 0.992259017667948 0.165698189978552 no 525 0.160535594744886 919 4736863 YCR052W RSC6
SGTC_493 zm226600 134 µM 0.991094511909564 0.165964180713247 no 526 0.160819716282852 815 5240098 A potassium channel opener. YCR052W RSC6
SGTC_295 k015-0027 31 µM 0.991023849495527 0.165980329952894 no 527 0.160836967386525 804 3887424
SGTC_3059 1327-0034 3 µM 0.988750686223857 0.166500382081005 no 528 0.161392568554527 792 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2345 9052315 157.45 µM 0.988492248172377 0.166559573813715 no 529 0.161455814516494 773 6469265
SGTC_2614 arthonioic acid 13.39 µM 0.987425995176716 0.166803928209761 no 530 0.161716922946306 754 6710684
SGTC_1910 st062352 60.4 µM 0.987163400574494 0.166864142784857 no 531 0.161781270406396 797 2245730
SGTC_1992 st073643 23.3 µM 0.987062920426474 0.16688718721634 no 532 0.161805896964217 793 3161292
SGTC_2732 terfenadine 20 µM 0.986213701783863 0.167082031663826 no 533 0.162014128491015 774 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_303 1348-1668 34.2 µM 0.979841654353131 0.168548709103679 no 534 0.163582143568409 819 5380509
SGTC_35 0133-0054 64.071 µM 0.978915468807233 0.168762579533518 no 535 0.163810874163421 765 99677
SGTC_1234 0326-0494 15.5 µM 0.978636437501322 0.168827046304863 no 536 0.163879824346986 826 1547813
SGTC_1166 k206-0078 225 µM 0.978287491444238 0.168907688288118 no 537 0.163966077352741 845 5404595
SGTC_2552 juarezic acid 87.02 µM 0.977856154474051 0.169007405135048 no 538 0.164072736567072 982 1549512
SGTC_3145 9085516 49.47 µM 0.976694676369278 0.169276104575858 no 539 0.164360165760648 785 25236195
SGTC_1330 1469-0054 61.8 µM 0.97488255874104 0.169695872075699 no 540 0.164809259279204 892 7102664
SGTC_3300 9124615 50.48 µM 0.973085899275387 0.17011271732153 no 541 0.165255305770852 824 24824903
SGTC_687 k029-0044 34.9 µM 0.972768276176966 0.17018647766088 no 542 0.165334241452327 891 5829338
SGTC_460 trequinsin 123 µM 0.971880065613451 0.170392852003208 no 543 0.165555108992105 896 5537 A vasodilator.
SGTC_571 k831-0106 44.2 µM 0.971859586323889 0.170397612223961 no 544 0.165560203739557 786 4783639
SGTC_3189 9110682 49.47 µM 0.971118134854232 0.170570013098986 no 545 0.165744727063577 810 17122418
SGTC_1932 st074806 40.9 µM 0.970015478925454 0.170826607004958 no 546 0.166019388316237 880 17251235
SGTC_1730 st033808 45.1 µM 0.969208943567602 0.171014448410842 no 547 0.166220474840174 905 1045166
SGTC_2793 7325131 81.82 µM 0.968363031948446 0.171211602418861 no 548 0.166431547662828 808 4176441
SGTC_1319 1306-0155 43.7 µM 0.964222194456587 0.172178790506382 no 549 0.167467269667299 861 3122360
SGTC_3346 9158254 43.5805 µM 0.964135406960482 0.172199098961758 no 550 0.16748902162242 832 17639500
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.956647961004791 0.173956929828531 no 551 0.169372486193008 865 94937 An inhibitor of serotonin biosynthesis.
SGTC_3348 9149464 3.537 µM 0.956188992758535 0.174065051859729 no 552 0.169488380003144 857 1951442
SGTC_2982 9019404 25.97 µM 0.954970547328922 0.174352295894427 no 553 0.169796295751156 716 22333232
SGTC_1344 1488-0097 29.1 µM 0.953260312180909 0.174755985244522 no 554 0.170229097376404 833 747966
SGTC_3317 9138495 8.753 µM 0.950961465074649 0.175299546418282 no 555 0.170811968959052 855 17020139
SGTC_1569 carminic acid 40.6 µM 0.950523054481788 0.175403329960265 no 556 0.17092327259677 885 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2369 9071472 200 µM 0.95042284002817 0.175427058876897 no 557 0.170948721546673 879 17296037
SGTC_379 3970-0972 5.9 µM 0.946189523801767 0.176431287506879 no 558 0.172025964275829 844 2898042 YBL034C STU1
SGTC_175 3793-3120 23.7 µM 0.943022586564048 0.177184922412825 no 559 0.172834675056434 814 5322297
SGTC_1412 3909-8563 178 µM 0.942470297411823 0.177316558374951 no 560 0.172975955626812 953 23767530
SGTC_316 k060-0003 58.6 µM 0.942305982035559 0.177355734219343 no 561 0.17301800318733 841 6152314
SGTC_3169 9102970 49.47 µM 0.942114568130134 0.177401377748135 no 562 0.173066993348862 885 17027839
SGTC_419 nsc-638432 893 µM 0.942092059453436 0.177406745533196 no 563 0.173072754763295 864 368090
SGTC_1812 st052057 4.327 µM 0.941052810793249 0.177654693322404 no 564 0.173338898206956 892 3645418
SGTC_1914 st062367 72.6 µM 0.939919591239435 0.17792531012302 no 565 0.173629403656897 819 978205
SGTC_1486 3970-0793 4.53 µM 0.937117749849351 0.178595514922717 no 566 0.174348996027438 896 2844330
SGTC_3020 9089140 49.47 µM 0.936077701138488 0.178844700268726 no 567 0.17461659156169 864 17217859
SGTC_1042 0350-0096 82 µM 0.934060156627846 0.179328707562025 no 568 0.175136431501836 842 3122515
SGTC_901 1112-0062 60.1 µM 0.93298166427458 0.179587774503563 no 569 0.175414717732604 847 1908457
SGTC_3272 9137413 49.47 µM 0.932667475590564 0.179663290655065 no 570 0.175495841366637 847 17614870
SGTC_2569 tetrandrine 100 µM 0.929586947926882 0.1804047608838 no 571 0.176292493929545 777 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2639 lactacystin 53 µM 0.928520753179845 0.180661836122061 no 572 0.176568753862689 903 3870 A proteasome inhibitor.
SGTC_3218 9131285 49.47 µM 0.926527589587127 0.181143032914059 no 573 0.177085932995651 947 17156417
SGTC_3292 9120825 59.784 µM 0.925653860975935 0.181354224523913 no 574 0.177312946444207 905 24824900
SGTC_579 4491-1009 110 µM 0.922832038467805 0.182037348270254 no 575 0.178047370899202 1083 1271041
SGTC_3301 9125354 19.7965 µM 0.920904784157795 0.182504832957144 no 576 0.178550070306348 805 41905162
SGTC_3223 9129970 49.47 µM 0.920191359250237 0.182678074962021 no 577 0.178736384464938 922 17248386
SGTC_227 fluconazole 33.516 µM 0.917653142434992 0.183295265954859 no 578 0.179400243244655 906 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_596 1155-0152 116 µM 0.916304212217128 0.183623799375322 no 579 0.179753679672739 921 280313
SGTC_2727 riluzole 51.77 µM 0.915905148845795 0.183721061983704 no 580 0.179858323012362 836 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_558 k064-0027 21.3 µM 0.912566756570399 0.184535975934714 no 581 0.18073522244814 912 5088526
SGTC_94 0334-0113 514.748 µM 0.911755382749986 0.184734374368678 no 582 0.180948751188574 907 6795178
SGTC_2378 9074213 121.43 µM 0.911140011244942 0.18488493438896 no 583 0.181110803496349 900 657714
SGTC_3016 9080866 49.47 µM 0.910892903684118 0.184945414474421 no 584 0.181175902528646 934 17066299
SGTC_385 1494-0393 12.4 µM 0.909860307525798 0.185198277513881 no 585 0.181448092468047 914 3090647
SGTC_1681 tripelennamine 100 µM 0.909810662486724 0.1852104400411 no 586 0.181461185230977 858 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_874 0599-0792 117 µM 0.909518481263288 0.185282031505333 no 587 0.181538253442025 968 765305
SGTC_88 0180-0332 8.668 µM 0.908398897478143 0.185556515641905 no 588 0.181833754017127 959 3101745
SGTC_794 k038-0031 316 µM 0.907941425161331 0.185668744989731 no 589 0.181954584828921 954 6624242
SGTC_422 cantharidin 155 µM 0.907760686768728 0.185713096220417 no 590 0.18200233656088 872 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_753 1322-0200 289 µM 0.907026334582436 0.185893365832827 no 591 0.182196435631612 928 5403907
SGTC_1169 aniline yellow 25.8 µM 0.906765500379982 0.185957421818238 no 592 0.182265408714786 877 6051 A DNA damaging agent.
SGTC_122 0236-0016 402.397 µM 0.906649457708342 0.185985924119091 no 593 0.182296099431535 963 6808838
SGTC_3091 9116372 49.47 µM 0.904880712927202 0.186420696906653 no 594 0.182764292925582 861 17169793
SGTC_2173 5763948 167 µM 0.904081915923786 0.186617254322956 no 595 0.182975983380228 924 2867177
SGTC_2087 5276107 200 µM 0.903193355886726 0.186836050139711 no 596 0.183211641754305 895 144405
SGTC_392 N-ethylmaleimide 8.33 µM 0.902632437527485 0.186974250358823 no 597 0.183360502456279 872 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2340 7987427 183.45 µM 0.901227456726161 0.187320689934884 no 598 0.183733697636377 852 2239331
SGTC_1409 3909-8004 61.9 µM 0.899362474779624 0.18778116896687 no 599 0.184229810068422 930 2119279
SGTC_341 1486-1430 230 µM 0.898694579445712 0.187946247569239 no 600 0.184407682531238 894 2054753 YPL210C SRP72
SGTC_270 tamoxifen 5.46 µM 0.896391176521047 0.188516249146697 no 601 0.18502193906963 977 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1609 st001574 46.4 µM 0.896015257553418 0.188609375377239 no 602 0.185122307224168 936 3960012
SGTC_2464 5717415 7.67 µM 0.893279624675075 0.18928792632144 no 603 0.185853723289355 919 5285744
SGTC_1902 st060212 70.5 µM 0.891967311382173 0.189613967408651 no 604 0.186205226855145 970 688944
SGTC_2560 caryophyllene 100 µM 0.890946577100284 0.189867805106438 no 605 0.18647891553285 1040 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_921 1561-0023 372 µM 0.890943080650329 0.189868674967653 no 606 0.186479853461197 942 24050882
SGTC_1046 2001-0062 216 µM 0.890799507290389 0.189904395855268 no 607 0.186518369770085 884 739778
SGTC_3033 9090887 49.47 µM 0.889311808307365 0.190274776829114 no 608 0.186917763534794 942 19325384
SGTC_3329 9141233 27.5565 µM 0.888001786621448 0.190601290006829 no 609 0.187269895135058 916 4909101 YNL103W MET4
SGTC_616 4092-0450 108 µM 0.884588140953336 0.191453730363439 no 610 0.188189402534546 947 787165
SGTC_2090 5301565 104.445 µM 0.882523388126324 0.191970463163744 no 611 0.188746918887288 955 2056344
SGTC_2824 7998404 51.95 µM 0.881289429061689 0.192279685497304 no 612 0.189080593073651 871 837851
SGTC_1279 0874-0590 65.2 µM 0.879470658079503 0.192736013050122 no 613 0.189573067824844 937 3523074
SGTC_229 benomyl 22.8748 µM 0.878508598813083 0.19297765997483 no 614 0.189833886681572 925 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1377 2944-0135 198 µM 0.876623128639825 0.193451782580532 no 615 0.19034568621276 959 1894137
SGTC_1848 st056003 16.4 µM 0.876613553232935 0.193454192236117 no 616 0.190348287560411 1019 146492
SGTC_3326 9140064 16.379 µM 0.87594809923942 0.19362169889338 no 617 0.190529124714303 955 1868434
SGTC_91 0417-1751 58.384 µM 0.875063625751811 0.193844473527255 no 618 0.190769643630545 1087 6795624
SGTC_3222 9128301 49.47 µM 0.871947740453637 0.19463052350574 no 619 0.191618443876811 944 4911358
SGTC_2529 gangaleoidin 93.61 µM 0.871925068217092 0.194636250169892 no 620 0.191624628499727 951 4565183
SGTC_1018 4259-0013 28.1 µM 0.870030161827711 0.195115237176666 no 621 0.192141960660382 935 6801262
SGTC_468 gf-109203x 121 µM 0.869249496960047 0.195312778791939 no 622 0.192355339824244 850 2396 A protein kinase C inhibitor.
SGTC_469 w7 172 µM 0.868722041582554 0.195446316330198 no 623 0.192499591222655 943 45115570 A P450 inhibitor.
SGTC_2734 clemastine 41.6 µM 0.868256661302992 0.195564184157443 no 624 0.192626920881804 872 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1038 k292-0204 154 µM 0.867589778569691 0.195733162151351 no 625 0.19280947201628 882 4454212
SGTC_1193 1488-0126 41.5 µM 0.867261845949145 0.195816287810678 no 626 0.192899278381764 982 1384710
SGTC_2142 5622915 118.518 µM 0.866814266394129 0.195929776618241 no 627 0.193021892021071 911 5322196
SGTC_1296 1068-0102 11.9 µM 0.864410207639142 0.196540035193984 no 628 0.193681293695431 948 767053
SGTC_1588 farnesol 29.9 µM 0.864159371720131 0.196603774951308 no 629 0.193750173731484 939 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1209 2323-2347 50.3 µM 0.863715616575897 0.196716567961486 no 630 0.193872066340264 973 5412760
SGTC_2936 9038235 15.59 µM 0.863350752955788 0.19680933779793 no 631 0.193972323684731 971 4749415
SGTC_541 4513-1321 94 µM 0.862786434832976 0.196952872887559 no 632 0.194127449407773 880 747515
SGTC_491 tetrandrine 80.3 µM 0.862336254656881 0.197067422261168 no 633 0.194251253859901 926 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_342 k048-0088 23.3 µM 0.862290658366403 0.197079026589666 no 634 0.194263796017556 952 6820570
SGTC_1928 4'-methoxychalcone 40.3 µM 0.860883520528102 0.197437348681052 no 635 0.194651099395245 1000 641818
SGTC_333 3486-0131 40.1 µM 0.859626612485054 0.197757748225292 no 636 0.194997450186834 996 6744690
SGTC_1380 2291-0730 164 µM 0.858964797316877 0.197926578312293 no 637 0.19517996899435 906 2999191
SGTC_3192 9110362 49.47 µM 0.857856325807641 0.198209546085557 no 638 0.195485901477364 989 16649480
SGTC_69 0096-0274 206.684 µM 0.857803275467745 0.198223094761374 no 639 0.195500550399456 1038 6741392
SGTC_1312 1218-2183 165 µM 0.854076315416377 0.199176332260641 no 640 0.196531353025193 1007 6744073
SGTC_1263 0774-1208 64.8 µM 0.853895863695659 0.19922255602944 no 641 0.196581345806073 1011 906585
SGTC_1692 fluoroquinolonic acid 71 µM 0.853095484403176 0.199427655758973 no 642 0.196803177677192 957 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1320 1313-0481 95.3 µM 0.850011852235718 0.200219033782492 no 643 0.197659248396892 1015 6813365 YLR208W SEC13
SGTC_1641 st009299 47.1 µM 0.848281142189552 0.200664025868033 no 644 0.198140708601828 933 4046054
SGTC_1513 0337-0559 19 µM 0.846820265167131 0.201040101453058 no 645 0.198547655448371 898 775073
SGTC_803 4488-1585 147 µM 0.846521916689814 0.201116957667715 no 646 0.198630826361752 967 747204
SGTC_2409 alverine citrate 63.97 µM 0.845840294961923 0.201292613290715 no 647 0.1988209215775 964 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1716 st033144 30.6155 µM 0.8455578732949 0.201365421000475 no 648 0.198899717340207 1008 674617
SGTC_840 0245-0196 390 µM 0.845349979957982 0.201419025548807 no 649 0.198957731692899 1015 3827528
SGTC_2731 amoxapine 43.43 µM 0.844605554263319 0.20161104316241 no 650 0.199165553452677 955 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2989 9073649 71.4286 µM 0.844589268478128 0.201615245153077 no 651 0.199170101426073 1033 21367202
SGTC_2291 7917025 104.35 µM 0.844256846794754 0.201701026679635 no 652 0.199262947277736 938 2964612
SGTC_1632 st005650 90 µM 0.843879391431008 0.201798455660159 no 653 0.199368402696242 939 2759605
SGTC_2621 lithochol-11-enic acid 100 µM 0.84378163206802 0.201823693953024 no 654 0.199395720686794 1005 6708711
SGTC_2580 diallyl disulphide 81.36 µM 0.842566456214144 0.202137570629213 no 655 0.199735478923326 920 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2401 5128683 200 µM 0.840370893364752 0.202705418700845 no 656 0.200350231799003 947 708373
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.840369606237142 0.202705751875652 no 657 0.200350592525031 1027 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_861 0443-0273 110 µM 0.840226327464422 0.202742841834794 no 658 0.200390749788089 1000 6149169
SGTC_3293 9120939 62.045 µM 0.840034492336308 0.202792507717455 no 659 0.200444523687528 950 934087
SGTC_3178 9107506 49.47 µM 0.839596394021722 0.20290595809336 no 660 0.200567360877875 960 8897194
SGTC_1248 0469-0687 58.6 µM 0.839112318035371 0.203031358969265 no 661 0.200703142175738 973 4017482
SGTC_2558 carylophyllene oxide 100 µM 0.838938563888318 0.203076381621273 no 662 0.200751892944814 1069 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2890 9046729 58.44 µM 0.838698276048098 0.203138654104766 no 663 0.200819322999531 905 903329
SGTC_1256 0570-0116 285 µM 0.838533671964218 0.203181319126169 no 664 0.200865522370814 947 410638
SGTC_2642 cholecalciferol 100 µM 0.83764206616594 0.203412514356197 no 665 0.201115879877607 987 9821465 A vitamin D precursor, similar to steriods.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.836805907088491 0.203629474686394 no 666 0.201350838244244 974 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2803 7707263 71.43 µM 0.834121536967956 0.204326927066086 no 667 0.202106249981645 939 2199229
SGTC_641 4092-0595 30 µM 0.833041403930254 0.204607967760434 no 668 0.202410689339342 999 786260
SGTC_2505 galangin 7.89 µM 0.831231439589734 0.205079419127267 no 669 0.20292144858482 911 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3140 9094243 49.47 µM 0.829342558324714 0.20557211424432 no 670 0.203455297666173 1080 19291112
SGTC_3129 9127257 49.47 µM 0.826422774496094 0.206335090755692 no 671 0.204282154331852 887 837894
SGTC_448 monastrol 171 µM 0.825600167394777 0.206550351040254 no 672 0.204515470078331 1017 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2906 7926292 26.41 µM 0.824701743726219 0.206785602956467 no 673 0.20477047074375 1022 2966319
SGTC_1752 st044819 83.042 µM 0.82438795849672 0.206867804867483 no 674 0.204859577319096 978 441209 YML126C ERG13
SGTC_2306 7482397 179.52 µM 0.824338082221255 0.206880872672179 no 675 0.20487374296485 995 891448
SGTC_2715 st079500 56.4 µM 0.820128568060867 0.207985543826058 no 676 0.206071408945706 965 28246688
SGTC_2481 5478948 45.16 µM 0.819583270608732 0.208128896465988 no 677 0.206226856908004 978 77792
SGTC_1557 sumaresinolic acid 42.3 µM 0.819517686072147 0.208146141839335 no 678 0.20624555777561 976 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_199 4063-0024 41.6 µM 0.816284216784016 0.20899742383954 no 679 0.207168799658885 1047 306215
SGTC_479 n-linoleoylglycine 10 µM 0.815586480169323 0.209181386993047 no 680 0.207368342289795 992 6433346 An anti-infammatory.
SGTC_245 methotrexate 289.6 µM 0.812712766865431 0.209940065890072 no 681 0.208191379862205 1011 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2623 humulene 100 µM 0.81197305281247 0.21013561656828 no 682 0.208403547064536 912 6187145 An anti-inflammatory.
SGTC_789 1309-1135 70.6 µM 0.810050906739154 0.210644254745819 no 683 0.208955459159733 1070 3092424
SGTC_2314 7727897 200 µM 0.809963375485324 0.210667434444261 no 684 0.208980612774099 1040 900724
SGTC_1531 st059297 52.4 µM 0.809832562793981 0.210702078559936 no 685 0.209018207379596 1033 7566702
SGTC_277 nystatin 15.5 µM 0.809808466547834 0.210708460515787 no 686 0.209025132897941 1072 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1024 4507-0395 26 µM 0.809555311496586 0.210775516168182 no 687 0.209097900529652 978 4201836
SGTC_2800 7887935 81.82 µM 0.806670128572759 0.211540626543293 no 688 0.209928279215197 987 2961002
SGTC_2656 pseudo-anisatin 100 µM 0.805473172030996 0.211858519396455 no 689 0.210273340863608 1043 6708809 A neurotoxin.
SGTC_2601 securinine 100 µM 0.805404529001391 0.21187675837629 no 690 0.210293139542 997 442872 A GABA receptor antagonist.
SGTC_589 1227-0070 34.1 µM 0.805100469917107 0.211957560254517 no 691 0.210380852330542 1023 2841384
SGTC_1463 k081-0032 34.1 µM 0.804682166719215 0.212068751270015 no 692 0.210501556536089 897 977755
SGTC_2465 5809242 33.21 µM 0.803973482465219 0.212257207576996 no 693 0.210706144888256 1048 2731748
SGTC_2868 9035608 32.47 µM 0.802684592134161 0.212600205524793 no 694 0.211078530381489 1072 6462614
SGTC_3019 9081971 49.47 µM 0.799906554945682 0.213340593240333 no 695 0.211882469838098 1082 16451803
SGTC_992 3909-8734 162 µM 0.79963382683168 0.213413360231912 no 696 0.211961491393314 1045 4288319
SGTC_343 4130-2827 29.8 µM 0.799186300319295 0.213532796785161 no 697 0.212091197220749 1033 1118244
SGTC_1276 0871-0068 94.2 µM 0.798708323150347 0.213660403062704 no 698 0.212229779750042 1015 3414906
SGTC_260 nsc-65238 3.989 µM 0.798085155825758 0.21382683766967 no 699 0.212410537519675 1009 3246252
SGTC_1898 st060199 18.6 µM 0.796359451067143 0.21428813017254 no 700 0.212911569795977 1085 688866
SGTC_3067 9117431 49.47 µM 0.796046623706124 0.214371812968085 no 701 0.21300246827813 1031 17150885
SGTC_1422 4031-0024 15.5 µM 0.795285202514554 0.214575576139779 no 702 0.213223809612901 1039 782427
SGTC_2080 5212524 12.4 µM 0.794889813346531 0.214681430238993 no 703 0.213338800157849 1026 260183
SGTC_38 0929-0051 58.268 µM 0.793094935880183 0.215162338566677 no 704 0.213861256542725 1078 1379719
SGTC_2244 6635614 200 µM 0.792657660037248 0.215279594203879 no 705 0.213988652405382 893 836499
SGTC_3123 9126162 49.47 µM 0.791361818031598 0.215627292289626 no 706 0.214366442103879 1122 25239884
SGTC_2785 7756463 72.73 µM 0.790756480002178 0.215789827060202 no 707 0.214543055157328 1081 2201551
SGTC_3172 9105863 49.47 µM 0.789532161675667 0.216118776546746 no 708 0.21490051996578 1032 2348785
SGTC_2189 6047310 154.431 µM 0.787709404821465 0.216609051966296 no 709 0.215433351569423 1038 711535
SGTC_2140 5586273 200 µM 0.786861869916435 0.216837236337223 no 710 0.215681365308044 1075 854421
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.786230074546513 0.217007426881178 no 711 0.215866354932074 1066 7104
SGTC_1711 st032263 62.8 µM 0.786053617847692 0.217054973878172 no 712 0.215918037858252 1027 3958979
SGTC_2964 9083345 53.42 µM 0.785883375017825 0.217100852227246 no 713 0.215967907580821 1027 17741579
SGTC_1339 1486-1321 22.7 µM 0.785881536371379 0.217101347750434 no 714 0.215968446217243 1034 3469382
SGTC_1540 guanosine 70.6 µM 0.785114598477561 0.217308097816646 no 715 0.216193190599086 1018 6802 Guanosine is a purine nucleoside
SGTC_1271 0832-2808 169 µM 0.783488329154014 0.217746881257541 no 716 0.216670202263048 1089 3663794
SGTC_3184 9108758 49.47 µM 0.782578915901803 0.217992472543988 no 717 0.216937213365626 1046 902885
SGTC_967 1306-0166 352 µM 0.781773331788906 0.218210157618241 no 718 0.217173898173713 1049 4437607
SGTC_2808 7946468 45.46 µM 0.780692703640023 0.218502361761348 no 719 0.217491626502047 1060 2970879
SGTC_3229 9132204 49.47 µM 0.780025516060614 0.218682883142524 no 720 0.217687928155484 1069 17682924
SGTC_1136 pergolide 1.05886 µM 0.778437484107562 0.219112903148076 no 721 0.218155574026364 1023 47811 A dopamine receptor agonist.
SGTC_2575 plumbagin 510 nM 0.778402215132203 0.219122459079343 no 722 0.218165966651449 1017 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2276 7947513 42.08 µM 0.774682631009473 0.220131603977622 no 723 0.219263608426475 1025 2105100
SGTC_2937 9044753 11.33 µM 0.77389411090765 0.220345876019835 no 724 0.219496706228238 1119 6465530 YGL099W LSG1
SGTC_3290 9121031 71.43 µM 0.772740815020404 0.220659487267606 no 725 0.219837893191504 1041 17014854
SGTC_951 1171-0579 82.7 µM 0.771136836906229 0.221096075560088 no 726 0.220312914086135 1119 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2442 5158906 48.48 µM 0.771099168030891 0.221106334623124 no 727 0.220324076856263 1069 1893835
SGTC_3163 9099914 49.47 µM 0.770391467832357 0.221299126359093 no 728 0.220533856537156 1079 16268368
SGTC_1759 st043059 70 µM 0.770052836336183 0.221391410371878 no 729 0.220634275681247 1106 669426
SGTC_3349 9149703 23.001 µM 0.767444067239053 0.222103090678197 no 730 0.22140876822956 1098 4910494
SGTC_2135 5326629 150.42 µM 0.767238396996679 0.222159253637851 no 731 0.221469893740325 1053 5020077
SGTC_144 4161-2749 112.381 µM 0.766934972907157 0.222242125316942 no 732 0.22156008945677 987 797501 YMR168C CEP3
SGTC_1424 4048-1941 275 µM 0.766570079349572 0.222341808994426 no 733 0.221668585362205 1147 X1424
SGTC_715 0868-0130 184 µM 0.760535483271608 0.223994068707984 no 734 0.223467283832951 1101 2876258
SGTC_2121 5257820 149.641 µM 0.760308755536153 0.224056281953509 no 735 0.223535024755102 1157 791256
SGTC_2684 capsaicin 100 µM 0.759985322509291 0.224145047756731 no 736 0.223631679159025 1080 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_6 0844-0013 19.835 µM 0.758365614016511 0.224589875126484 no 737 0.22411606859065 1236 1584900
SGTC_471 1-acyl-paf 4 µM 0.756612641289933 0.225071865226322 no 738 0.224640982805852 1083 16759367
SGTC_55 0767-0285 6.563 µM 0.756391984183008 0.225132577692642 no 739 0.224707106261547 1094 3116166
SGTC_486 niguldipine 82 µM 0.756117826290116 0.225208023499861 no 740 0.224789277464896 1063 1236 A calcium channel blocker.
SGTC_1942 st076330 65.2 µM 0.753309281099453 0.225981734430472 no 741 0.225632041454388 1155 24208414
SGTC_1504 k297-0033 30 µM 0.752540898889202 0.226193673400848 no 742 0.225862922041862 1022 4388117
SGTC_1683 st010134 710 nM 0.751894543462419 0.226372041282854 no 743 0.226057239899157 1154 3818134
SGTC_3088 9117578 49.47 µM 0.750418088418085 0.22677978083225 no 744 0.226501470045161 1169 678341
SGTC_1647 st011722 22.4 µM 0.747663808584766 0.22754151233434 no 745 0.227331483109379 1090 2854783
SGTC_403 arphamenine a 50 µM 0.746640739946596 0.227824821690652 no 746 0.227640224821962 1085 5487158 An arginine aminopeptidase inhibitor.
SGTC_510 ag-490 170 µM 0.745833847856499 0.228048407132508 no 747 0.227883895186606 1220 5328779
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.745790498617662 0.228060422464603 no 748 0.227896990215867 1117 2333 A French combination drug.
SGTC_2735 sertaconazole 140 nM 0.7442176693208 0.228496612405432 no 749 0.228372400056682 1140 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_941 3237-0776 460 µM 0.741312867366924 0.229303426693355 no 750 0.22925188080975 1123 760008
SGTC_1962 st076595 64.5 µM 0.740865247580584 0.229427895809241 no 751 0.229387574375213 1147 279619
SGTC_1079 idarubicin 2.36 µM 0.74073374274655 0.229464470401424 no 752 0.229427447922633 1096 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2870 9038528 12.99 µM 0.739386107388986 0.229839467798838 no 753 0.229836287903574 1109 6463316
SGTC_2138 5575593 77.673 µM 0.738954744181026 0.229959572777628 no 754 0.229967239197138 1143 762213
SGTC_33 0986-0033 35.816 µM 0.737368083542502 0.230401650716865 no 755 0.230449269577518 1088 2848082
SGTC_2192 5915882 198.485 µM 0.736347196209564 0.230686343005506 no 756 0.230759715374293 1080 2876149
SGTC_337 1315-0038 354 µM 0.73534203804963 0.230966840841805 no 757 0.231065606113995 1100 1626437
SGTC_2987 9018338 71.43 µM 0.735334718335889 0.230968884167558 no 758 0.231067834486326 1140 5055682
SGTC_2258 7960471 200 µM 0.732212540534107 0.23184137154182 no 759 0.23201942561932 1101 2974708
SGTC_2044 5102272 200 µM 0.731690557832341 0.231987417646773 no 760 0.232178730423623 1119 592666
SGTC_516 3992-2719 87.3 µM 0.73134525482121 0.232084058495493 no 761 0.232284147492367 1120 5350887 YDR037W KRS1
SGTC_3280 9140961 49.47 µM 0.730728286633504 0.232256786761915 no 762 0.232472567120927 1119 4901226
SGTC_2323 6148992 148.28 µM 0.729346713303128 0.232643835485801 no 763 0.232894802224841 1092 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2259 7964009 200 µM 0.728462850363732 0.232891638238884 no 764 0.233165150859552 1144 313134
SGTC_26 0302-0163 425.158 µM 0.728386580267663 0.23291302844684 no 765 0.23318848788372 1171 3100915
SGTC_595 3909-8003 73.7 µM 0.728159152332618 0.232976817863445 no 766 0.233258083682354 1158 699517
SGTC_2074 5212007 75.395 µM 0.728099445384897 0.232993566188775 no 767 0.233276356666989 1083 758611
SGTC_2018 5133068 143 µM 0.726575216380734 0.233421352216436 no 768 0.233743107522304 1132 785362
SGTC_929 2805-0021 398 µM 0.726480178527823 0.233448039708916 no 769 0.233772227238666 1137 3098024
SGTC_1489 4065-0444 182 µM 0.725966731435764 0.233592249586261 no 770 0.233929582836477 1141 2877968
SGTC_997 3996-0078 137 µM 0.723638634071588 0.234246752590765 no 771 0.234643808184637 1196 735687
SGTC_2193 5925765 200 µM 0.72344093186482 0.234302379762607 no 772 0.234704515757526 1157 877370
SGTC_344 k064-0035 6.43 µM 0.723423447134427 0.234307299766726 no 773 0.23470988513702 1134 5088750
SGTC_3077 9117319 49.47 µM 0.721878959073687 0.234742126674358 no 774 0.235184449295055 1179 17154678
SGTC_2556 citropten 84.59 µM 0.721546109430091 0.234835893781517 no 775 0.23528679105915 1159 2775 A potential DNA crosslinker.
SGTC_2319 6033012 152.6 µM 0.719781915446618 0.235333230549338 no 776 0.235829640654645 1108 847246
SGTC_601 0986-0029 62.9 µM 0.718562922972879 0.235677211149907 no 777 0.236205132557735 1150 24747981
SGTC_408 cantharidin 100 µM 0.716615824672369 0.236227226568976 no 778 0.236805588714567 1121 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2267 7931562 200 µM 0.716401213120339 0.236287893163124 no 779 0.236871823043753 1108 934880
SGTC_3302 9125395 16.351 µM 0.715636259252701 0.23650420080815 no 780 0.237107989190248 1132 17599668
SGTC_1159 4092-0538 61.2 µM 0.714614958933602 0.236793165882392 no 781 0.237423499400692 1212 717301
SGTC_207 4185-0010 4.486 µM 0.7145835103622 0.236802066971002 no 782 0.237433218461522 1224 3761753
SGTC_1130 3454-2858 15.9 µM 0.713579083094277 0.237086453152054 no 783 0.237743747734059 1109 715628 YIL048W NEO1
SGTC_855 0428-0020 25 µM 0.713063667909511 0.237232456859834 no 784 0.237903180217113 1143 6812414
SGTC_2654 protoveratrine a 100 µM 0.71205945375146 0.237517066393693 no 785 0.23821398034795 1166 5702278 A heart drug and vasodilator.
SGTC_3312 9133330 71.43 µM 0.7119155001122 0.237557880392588 no 786 0.238258551626856 1207 17617324
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.711315870969479 0.23772792974384 no 787 0.238444259411143 1199 279621
SGTC_2385 9074692 200 µM 0.711010057310487 0.23781468141104 no 788 0.238539001755562 1173 17046906
SGTC_1755 st041960 45.185 µM 0.710731624174038 0.237893681008206 no 789 0.238625279418574 1176 2257073
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.71006608285176 0.238082572774602 no 790 0.23883157890283 1185 2724 A muscle relaxant with antifungal properties.
SGTC_925 2064-1272 59.6 µM 0.709872757928076 0.238137457025993 no 791 0.238891522585113 1144 6815817
SGTC_2789 5281112 71.43 µM 0.709823911972119 0.238151325314518 no 792 0.238906669406911 1170 765948
SGTC_937 3122-0005 46.7 µM 0.709555124957057 0.238227646936905 no 793 0.238990027954909 1176 759535
SGTC_3143 9086658 49.47 µM 0.7092723534255 0.238307953900911 no 794 0.239077740663709 1217 25236626
SGTC_2168 5727979 200 µM 0.708440551355486 0.23854427118378 no 795 0.239335858764014 1120 695210
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.707119115403907 0.238919958433001 no 796 0.23974622891128 1144 4620898
SGTC_819 1013-0258 27.7 µM 0.706194083910926 0.239183139393797 no 797 0.240033724483005 1203 5753198
SGTC_2923 7992654 58.14 µM 0.704825997240134 0.239572664342359 no 798 0.240459263938452 1187 2985126
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.703967403565818 0.239817301964729 no 799 0.240726536744928 1178 688667
SGTC_1612 st002233 45.4 µM 0.703469890834648 0.239959119753142 no 800 0.240881482120779 1219 1035021
SGTC_2892 9047358 58.44 µM 0.703055373020029 0.240077314461143 no 801 0.241010620979635 1174 6466771
SGTC_2972 9093619 59.92 µM 0.701918292242226 0.240401702084228 no 802 0.241365060278279 1187 25236256
SGTC_3268 9137683 49.47 µM 0.701888621152186 0.240410169879584 no 803 0.241374312839556 1167 1953228
SGTC_2597 laccaic acid a 100 µM 0.701382967207584 0.240554502800693 no 804 0.241532024368628 1158 5491415 A textile dye.
SGTC_435 c-PAF 6.7 µM 0.700968432523437 0.240672861993721 no 805 0.241661357880352 1156 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_308 4092-1169 104 µM 0.700914713879218 0.240688202222652 no 806 0.241678120678844 1173 2268590 YDL196W YDL196W
SGTC_2161 5662504 8.5105 µM 0.700174436561625 0.240899654590204 no 807 0.241909187046178 1158 2859334
SGTC_1290 0986-0249 10.2 µM 0.699646217333624 0.24105059656857 no 808 0.242074135929864 1161 53329
SGTC_2807 7945238 51.95 µM 0.69919978927732 0.241178206291015 no 809 0.242213591136876 1210 17148797
SGTC_814 3342-0569 96 µM 0.696994734353073 0.241809050947834 no 810 0.242903044575651 1226 4346283
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.695991065829884 0.242096486963636 no 811 0.243217212412321 1239 688751
SGTC_262 fenpropimorph 62.5 µM 0.6957948886255 0.242152690888804 no 812 0.243278645360276 1148 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2750 bromebric acid 70.15 µM 0.694067456043854 0.242647898146174 no 813 0.243819953268671 1209 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2762 leflunomide 42.06 µM 0.693595318726657 0.24278334223655 no 814 0.243968015154589 1185 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_217 ketoconazole 989 nM 0.691884049155513 0.24327460435074 no 815 0.244505074220996 1154 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_674 0498-0004 451 µM 0.691605173753555 0.243354713293254 no 816 0.244592655849483 1176 4231473
SGTC_2459 5811157 9.22 µM 0.688185609796632 0.24433816544676 no 817 0.245667952342104 1189 2870684 YBR192W RIM2
SGTC_3034 9090421 49.47 µM 0.688132077908305 0.244353578001985 no 818 0.245684805830964 1147 17173761
SGTC_3198 9112019 49.47 µM 0.687566483786961 0.244516452213321 no 819 0.245862910225415 1242 45595555
SGTC_2171 5739187 198.077 µM 0.686617828112297 0.244789767967535 no 820 0.246161795419905 1164 2262761
SGTC_1065 prochlorperazine maleate 2.48 µM 0.685086675014813 0.245231252873737 no 821 0.246644614085007 1256 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3355 9151058 44.0485 µM 0.683316356326773 0.245742230717733 no 822 0.247203480458762 1230 17015728
SGTC_2725 haloperidol 53.21 µM 0.683129530350952 0.245796188761646 no 823 0.2472624984447 1186 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_692 k241-0027 77.8 µM 0.682820914014139 0.245885335552169 no 824 0.247360006282711 1255 3600480
SGTC_2760 etidronate 98.04 µM 0.681976351453762 0.246129384246985 no 825 0.247626952263082 1221 3305 A chelator and antioxidant.
SGTC_989 1501-0895 10.3 µM 0.681538511586048 0.246255955590254 no 826 0.247765403489739 1215 2830112
SGTC_2805 7950783 58.44 µM 0.68000194543407 0.246700424216405 no 827 0.248251614543349 1214 1178958 YDL195W SEC31
SGTC_2243 6634756 200 µM 0.679075835612075 0.246968518991021 no 828 0.248544906256448 1259 885676
SGTC_51 1013-0126 23.419 µM 0.678821604929213 0.247042142188397 no 829 0.24862545140172 1306 1627850
SGTC_1071 trifluoperazine 6.31 µM 0.678518646493885 0.247129891888998 no 830 0.248721452584684 1267 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1950 st077106 7.18 µM 0.67830772866037 0.247190992542647 no 831 0.248788299682034 1205 13831864
SGTC_1446 4239-0190 62 µM 0.678273767955108 0.247200831352905 no 832 0.248799063888629 1238 1340085
SGTC_728 3030-5151 22.5 µM 0.678040307316176 0.247268473275891 no 833 0.248873068431002 1236 3125388
SGTC_1734 st037168 69.4 µM 0.67659936414992 0.247686185150659 no 834 0.249330091329045 1215 708907
SGTC_515 4092-1064 102 µM 0.676403061576496 0.247743120027969 no 835 0.249392386987227 1247 717353
SGTC_2420 aureobasidin a 50 nM 0.675794108318096 0.247919783048333 no 836 0.249585687941605 1281 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_25 0118-0223 35.662 µM 0.674200756411805 0.248382347229908 no 837 0.250091844404035 1262 5333628
SGTC_1845 st056753 3.01 µM 0.674107261254738 0.24840950398405 no 838 0.250121561701772 1191 5375839
SGTC_872 0588-0139 234 µM 0.673894378069069 0.248471344280984 no 839 0.250189233295706 1249 2047100
SGTC_1482 3346-2049 8.48 µM 0.672917590553446 0.248755195792262 no 840 0.250499860277558 1220 3826804
SGTC_1122 capsaicin 818.572 nM 0.672447138996057 0.248891969179795 no 841 0.250649540875039 1267 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_128 0906-2981 13.371 µM 0.671921815156326 0.249044742760556 no 842 0.25081673580632 1220 6740226
SGTC_3279 9140807 49.47 µM 0.670613979272567 0.249425301476019 no 843 0.251233237357424 1262 45595718
SGTC_226 1,3-diallylurea 8.28947 mM 0.668478175407607 0.250047449138442 no 844 0.251914204297914 1198 74537 YKL182W FAS1
SGTC_1825 st052143 62.6 µM 0.667314705988973 0.250386707339496 no 845 0.252285567403883 1256 674173
SGTC_2280 7785178 200 µM 0.666715317240497 0.250561579391227 no 846 0.25247699647018 1242 2954328
SGTC_2106 5357045 167.29 µM 0.665630887031846 0.250878126960297 no 847 0.25282352949134 1257 668842
SGTC_3004 9076122 71.4286 µM 0.664683010453676 0.251154987506539 no 848 0.253126631334377 1229 44782551
SGTC_2712 st079126 47.7 µM 0.664536412204215 0.251197821083596 no 849 0.253173526016458 1219 3152970
SGTC_986 1493-0483 84 µM 0.663623581548125 0.251464621961782 no 850 0.2534656302518 1201 40079
SGTC_3175 9106517 49.47 µM 0.66095623033856 0.252245088983728 no 851 0.254320191812798 1241 41468073
SGTC_1633 st005664 67.9 µM 0.660806288042651 0.252288999990577 no 852 0.254368274874765 1250 2063822
SGTC_75 0159-0059 199.013 µM 0.65857103962653 0.252944076101586 no 853 0.255085632453676 1362 5377270
SGTC_1905 st060207 84.5 µM 0.658196759788109 0.253053852356018 no 854 0.255205853311435 1200 1948547
SGTC_1075 aripiprazole 15.2 µM 0.657845529058639 0.25315689110041 no 855 0.255318697601797 1283 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2342 7990637 118.86 µM 0.656804559814517 0.25346240443586 no 856 0.255653295951957 1288 2033102 YER133W GLC7
SGTC_2203 7227154 166.4 µM 0.656299455010428 0.253610717075207 no 857 0.255815734072424 1245 896304
SGTC_231 b-estradiol 524 µM 0.654811282900514 0.254047950131756 no 858 0.256294632664418 1202 450 A steroid.
SGTC_666 0272-0154 136 µM 0.654618800338217 0.254104531423625 no 859 0.256356608287845 1282 6870312
SGTC_309 k408-0051 1.48 µM 0.654481114852 0.254145008872989 no 860 0.256400945114872 1241 3640463
SGTC_2075 5212009 200 µM 0.653949424295216 0.254301349588896 no 861 0.256572195086337 1212 780898
SGTC_2833 9001315 45.46 µM 0.653431605066182 0.254453659965276 no 862 0.25673903454398 1275 2989378
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.652337033692668 0.254775772385373 no 863 0.257091887211312 1305 364106
SGTC_2178 5812956 200 µM 0.651283588498419 0.255085983596054 no 864 0.257431720207319 1253 5403383
SGTC_1027 k015-0025 8.67 µM 0.650176043169373 0.255412338758441 no 865 0.257789256981241 1245 3598955
SGTC_761 k216-0224 480 µM 0.6499643960056 0.255474728653617 no 866 0.257857610045008 1315 1340404
SGTC_2195 6536160 144.242 µM 0.645399702434323 0.256822256124255 no 867 0.259334098097631 1176 3834386
SGTC_147 4466-0538 29.23 µM 0.64384427826408 0.257282271126544 no 868 0.259838208964771 1338 6742687 YHR072W ERG7
SGTC_2079 5212404 121 µM 0.641401024269718 0.258005724621511 no 869 0.260631083837072 1294 758462
SGTC_2444 5485484 36.41 µM 0.640830646610585 0.258174766632521 no 870 0.260816359614314 1346 6790631
SGTC_2485 5633444 17.78 µM 0.640654835334204 0.258226883143604 no 871 0.260873482050213 1256 5724239
SGTC_2434 5670830 169.91 µM 0.640225090778321 0.258354297168017 no 872 0.26101313644546 1274 1549830
SGTC_3043 9092303 49.47 µM 0.640180227939772 0.258367600330644 no 873 0.261027717769682 1233 25236084
SGTC_1258 0671-0043 57.1 µM 0.638587706979176 0.258840059860073 no 874 0.261545590244754 1271 4298767
SGTC_2649 anisomycin 9.56 µM 0.638036812787412 0.259003599838447 no 875 0.261724858434266 1246 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1506 4226-2149 212 µM 0.636706960518514 0.25939860356574 no 876 0.262157869420967 1328 991114
SGTC_163 TUB2.036 7.546 µM 0.635913782347204 0.259634347984719 no 877 0.262416309504855 1293 15992207 YJR013W GPI14
SGTC_1954 st077032 68.9 µM 0.63589742584289 0.259639210546149 no 878 0.262421640293197 1209 698907
SGTC_1192 1488-0095 21.4 µM 0.635841507584773 0.25965583462229 no 879 0.262439865168308 1287 915875
SGTC_1668 st014914 51.6 µM 0.635609958479346 0.25972467827161 no 880 0.262515338534712 1288 2839556
SGTC_1137 ixabepilone 100 µM 0.634892025906763 0.259938192207688 no 881 0.262749419063677 1289 154225 A novel microtubule stabilizer.
SGTC_1297 1068-0111 14.1 µM 0.634757004698468 0.259978357775231 no 882 0.262793454392886 1240 767057
SGTC_1810 st050138 53 µM 0.63391055077712 0.260230230401634 no 883 0.263069599794361 1285 3444541
SGTC_2561 acetosyringone 100 µM 0.633268996714001 0.260421216332031 no 884 0.263278997828942 1284 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1228 0124-0032 52.5 µM 0.632771380042616 0.260569402856931 no 885 0.263441474466997 1350 X1228
SGTC_786 4544-0069 423 µM 0.632539585412962 0.260638444382149 no 886 0.26351717511709 1348 748821 YLR208W SEC13
SGTC_2872 9044037 25.97 µM 0.63176585998439 0.260868971643746 no 887 0.263769942589977 1302 6465195
SGTC_2265 7929201 200 µM 0.631609873292658 0.260915459725762 no 888 0.263820916675672 1280 1265108
SGTC_2402 5553605 200 µM 0.63082145462399 0.261150494122276 no 889 0.264078636772037 1344 6758546
SGTC_1491 4138-0063 26.5 µM 0.629877856133476 0.261431931936973 no 890 0.264387250939667 1260 23883227
SGTC_183 3914-0051 30.55 µM 0.628639120634322 0.261801633654398 no 891 0.26479267139306 1293 1596232
SGTC_1955 wogonin 32.4 µM 0.628244552770954 0.26191944907612 no 892 0.264921874164391 1371 5281703 A flavanone.
SGTC_2443 5493264 126.67 µM 0.626586525035856 0.262414822457773 no 893 0.265465151714696 1319 5340055
SGTC_416 estradiol valerate 100 µM 0.6244039044449 0.263067660473035 no 894 0.266181180775539 1299 13791 A steroid.
SGTC_647 0140-0236 81 µM 0.623506077762772 0.263336447823571 no 895 0.266476004777914 1307 990837
SGTC_2694 st077685 81.9 µM 0.621385942599966 0.263971720528019 no 896 0.267172859500052 1275 2838096
SGTC_1939 st074455 53.6 µM 0.620396315525841 0.264268517392352 no 897 0.267498448784692 1386 1644229
SGTC_1648 st011736 69.8 µM 0.620164918948437 0.264337939530473 no 898 0.267574607571983 1348 2855514
SGTC_2733 amorolfine 100 µM 0.620161208161818 0.264339052892846 no 899 0.267575828979914 1348 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1313 1220-0047 237 µM 0.620092149379046 0.26435977331541 no 900 0.267598560237966 1359 3528706
SGTC_2440 5628896 157.78 µM 0.619817970259945 0.26444204627606 no 901 0.267688818120899 1353 5522048
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.618871740246454 0.264726081682817 no 902 0.268000428337702 1308 442882
SGTC_1438 4092-1045 4 µM 0.618563883001643 0.264818526431924 no 903 0.268101850515561 1292 1351342
SGTC_2925 9010536 32.5 µM 0.617733933110203 0.265067829226546 no 904 0.268375369967065 1351 2994177
SGTC_530 4358-1714 28 µM 0.61744717800385 0.265153993274585 no 905 0.268469905992279 1352 1564641
SGTC_228 caffeine 993.056 µM 0.61638983814456 0.265471825163344 no 906 0.268818629260975 1319 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1462 k081-0014 26.5 µM 0.615766037636392 0.265659427574431 no 907 0.269024472738628 1132 3270634
SGTC_2191 5911152 200 µM 0.615423475767699 0.265762478573441 no 908 0.269137545926736 1313 2875902
SGTC_2502 avocadyne acetate 18.59 µM 0.615103379607651 0.265858789647812 no 909 0.269243225156544 1281 3952079
SGTC_68 0986-0284 82.829 µM 0.614919936322698 0.265913992345727 no 910 0.269303798041023 1278 423278 YIL048W NEO1
SGTC_2938 9059746 27.26 µM 0.61487763425026 0.265926722927207 no 911 0.269317767134596 1305 6471769
SGTC_2196 6573537 42.6665 µM 0.614858100089033 0.265932601732325 no 912 0.269324217875612 1365 2903087
SGTC_1052 3253-3998 198 µM 0.611363316517701 0.266985415300391 no 913 0.270479541186233 1293 5450317
SGTC_246 cycloheximide 667 µM 0.609994002788422 0.267398498218461 no 914 0.270932890151154 1231 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3167 9103034 49.47 µM 0.609848646432461 0.267442367007517 no 915 0.270981036620521 1328 5127859
SGTC_1461 k072-0203 53.8 µM 0.609749386500603 0.267472325904939 no 916 0.27101391699732 1270 5418714
SGTC_1277 0873-0036 22 µM 0.609383496334463 0.267582774466697 no 917 0.271135137234835 1389 5965735
SGTC_766 1391-0721 126 µM 0.607176160216567 0.26824957409992 no 918 0.27186700573636 1387 1020919 YIL115C NUP159
SGTC_1964 st076914 61 µM 0.60680982863815 0.268360317622474 no 919 0.271988562347655 1320 24208661
SGTC_362 0310-0100 9.03 µM 0.604007453935145 0.269208246894569 no 920 0.272919343230658 1353 790235
SGTC_708 3448-5400 146 µM 0.603624039520728 0.269324363044975 no 921 0.273046813245738 1318 3462195
SGTC_613 3914-0030 117 µM 0.603410660814241 0.269388995158527 no 922 0.273117765943148 1177 1145395
SGTC_2714 st079313 56.9 µM 0.603352562426507 0.269406594426198 no 923 0.273137086404262 1331 2939799
SGTC_2895 9054447 58.44 µM 0.60289501099798 0.269545216866356 no 924 0.273289267556258 1352 2697450
SGTC_3227 9130768 49.47 µM 0.602889240646255 0.269546965313856 no 925 0.273291187037658 1364 17720899
SGTC_582 0987-0078 156 µM 0.602824849240963 0.269566476640336 no 926 0.273312607000373 1349 1625765
SGTC_535 2293-4129 48.2 µM 0.602354916400941 0.269708893048991 no 927 0.273468956513268 1366 396118 YIL048W NEO1
SGTC_3338 9144300 39.5675 µM 0.601668021187507 0.269917129188411 no 928 0.27369757035575 1341 4901274
SGTC_2172 5754775 163.918 µM 0.599572107606467 0.27055301414117 no 929 0.274395720323421 1269 2263357
SGTC_2287 7945887 168.79 µM 0.594895926446762 0.271974425607365 no 930 0.275956520198721 1361 1245853
SGTC_1440 4100-1550 40 µM 0.592619785324952 0.272667642068792 no 931 0.276717817481372 1363 742806
SGTC_733 4069-0007 56.1 µM 0.591488281242155 0.273012576432214 no 932 0.277096652391312 1389 5717425 YNL287W SEC21
SGTC_165 k038-0023 64.381 µM 0.591249886428558 0.273085277689902 no 933 0.277176500880073 1318 46368543
SGTC_2177 5811945 192 µM 0.591100725500128 0.273130770921057 no 934 0.277226466897589 1401 5343475
SGTC_3079 9117512 49.47 µM 0.590419627734649 0.273338549565325 no 935 0.277454677413546 1414 7185044
SGTC_1111 tnp00062 510.699 nM 0.589678652241127 0.273564683638299 no 936 0.277703054974253 1449 676306
SGTC_1665 st014639 11.4 µM 0.589384023438226 0.273654625436414 no 937 0.27780184573978 1412 981133 YIL048W NEO1
SGTC_2499 avocadenofuran 51.48 µM 0.589322677427911 0.273673354469548 no 938 0.277822417575008 1293 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2749 bexarotene 57.39 µM 0.584825576211905 0.275048051138583 no 939 0.279332502535328 1340 82146 An retinoic acid receptor inhibitor.
SGTC_271 rotenone 740 µM 0.580699713991113 0.276312250144816 no 940 0.280721427261244 1400 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_545 4218-0007 221 µM 0.579917055683403 0.276552384534659 no 941 0.280985276731272 1349 2840508
SGTC_164 4100-3994 89.624 µM 0.579508750574508 0.276677700869196 no 942 0.281122971945215 1445 4615967
SGTC_2625 euphol 100 µM 0.578472778200398 0.276995784626437 no 943 0.281472485393996 1410 6708538 A triterpene alcohol.
SGTC_2467 5474540 200 µM 0.577063033343054 0.277428918395359 no 944 0.281948437651538 1331 5413519
SGTC_2033 5192550 145 µM 0.574739529700498 0.278143519595973 no 945 0.282733734415537 1347 182073
SGTC_3221 9128209 49.47 µM 0.574578163384109 0.278193181657759 no 946 0.282788311937302 1398 16460723
SGTC_201 4262-0159 12.803 µM 0.574200226561447 0.278309512331051 no 947 0.282916158016619 1361 1341029
SGTC_815 1582-0027 36.9 µM 0.573387896069132 0.278559631582148 no 948 0.283191041937742 1412 3128206
SGTC_543 3844-1095 191 µM 0.573335650946179 0.278575721775172 no 949 0.28320872551112 1428 4230703
SGTC_2052 5265182 7.135 µM 0.573287086960742 0.278590678675712 no 950 0.283225163593178 1442 1239884
SGTC_1520 flindersine 88 µM 0.571394274916442 0.279173937815788 no 951 0.283866204514891 1523 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2629 bisabolol 100 µM 0.571119710978008 0.279258592384824 no 952 0.283959249059187 1426 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_757 1066-0008 322 µM 0.570221800395532 0.279535526572142 no 953 0.284263635894695 1435 6842497
SGTC_1889 st059080 5.18 µM 0.566664671540475 0.280633927235788 no 954 0.285471013780615 1421 176925 Isolated from Daphnopsis sellowiana.
SGTC_2884 9058502 51.95 µM 0.566285711652163 0.280751068675293 no 955 0.2855997859553 1370 6471554
SGTC_637 1181-0519 7.26 µM 0.564688528657426 0.281245038443107 no 956 0.286142819058262 1382 6252091 YGR060W ERG25
SGTC_1883 5-benzylidenerhodanine 20 µM 0.564629569802646 0.281263281008017 no 957 0.286162874115831 1408 1273210
SGTC_1735 st034310 56.75 µM 0.564497283406717 0.281304214057621 no 958 0.286207874218593 1486 871153
SGTC_2675 theaflavin digallate 100 µM 0.564354642902911 0.281348354174916 no 959 0.286256400262317 1396 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2691 st077356 60.2 µM 0.559886120878825 0.282732828794805 no 960 0.287778558082053 1479 2839272
SGTC_2335 9018011 154.17 µM 0.559047655861264 0.282992973262715 no 961 0.28806459838126 1477 6458208
SGTC_233 rapamycin 362 pM 0.558990960569592 0.283010567846981 no 962 0.288083944684249 1421 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3000 9075062 71.4286 µM 0.558329171962039 0.28321598343798 no 963 0.288309814116841 1384 17057871
SGTC_2433 5607874 27.82 µM 0.557771284947733 0.283389204079382 no 964 0.288500286628363 1369 2252428
SGTC_2245 6637752 200 µM 0.55755474159856 0.283456453198769 no 965 0.288574234336883 1447 681890
SGTC_1806 st050005 60.3 µM 0.55672371367258 0.283714605975495 no 966 0.288858106153697 1364 5194765
SGTC_1977 st070720 65.3 µM 0.556244115512454 0.283863640876447 no 967 0.289021992450216 1390 682188
SGTC_325 2810-4341 181 µM 0.553388863974957 0.284751683718494 no 968 0.289998581350058 1478 774970
SGTC_2431 5490079 200 µM 0.552221840941124 0.285115033577811 no 969 0.290398186093937 1402 5722345
SGTC_1125 tnp00248 1.32998 µM 0.552066026760683 0.285163562672821 no 970 0.290451558514863 1508 24207736
SGTC_3296 9122258 64.045 µM 0.54941031865207 0.285991300818133 no 971 0.291361947168568 1430 4730474
SGTC_1295 1013-0063 9.78 µM 0.549376639960062 0.286001805210644 no 972 0.291373500920444 1456 6826038
SGTC_700 3453-2283 142 µM 0.548638004856403 0.286232231783279 no 973 0.291626949499746 1483 565664
SGTC_549 1661-1316 519 µM 0.548140378121565 0.286387522433769 no 974 0.291797758568289 1485 2857282
SGTC_3015 9080845 49.47 µM 0.547725372386669 0.286517060740336 no 975 0.291940243832176 1506 5296973
SGTC_1229 0139-0193 12.2 µM 0.547579474407582 0.286562607382074 no 976 0.291990343154515 1467 3090752
SGTC_3250 9135583 49.47 µM 0.545594593843625 0.287182591205727 no 977 0.292672320664518 1474 7699353
SGTC_1050 3232-1156 69.3 µM 0.545412230142769 0.287239584927217 no 978 0.292735015403037 1384 700529
SGTC_899 1083-0020 478 µM 0.544734997480613 0.28745128578278 no 979 0.292967895498975 1470 767123
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.543139842779227 0.287950217638442 no 980 0.293516761007215 1441 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1162 k048-0130 20.1 µM 0.541864243453904 0.288349493065733 no 981 0.293956015340313 1407 6797406
SGTC_1164 k060-0068 93.7 µM 0.541464121706923 0.288474788959816 no 982 0.294093860398412 1444 5963676
SGTC_1124 fisetin 1.16336 µM 0.540658392463855 0.288727176409053 no 983 0.294371531011184 1428 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2536 dehydroabietamide 32.04 µM 0.540580719860263 0.2887515121484 no 984 0.294398304958977 1533 3983547
SGTC_736 0958-0254 92.6 µM 0.540580423157701 0.288751605110651 no 985 0.294398407235274 1485 6812352
SGTC_2728 chlorpromazine 9.18 µM 0.540511028824177 0.288773347990844 no 986 0.294422328596632 1431 2726 A thorazine and dopamine antagonist.
SGTC_680 0417-1641 114 µM 0.540107614280969 0.288899762537987 no 987 0.294561409952644 1397 2835990
SGTC_2122 5258151 111.688 µM 0.539653440554562 0.289042114210638 no 988 0.294718027331094 1385 2173356
SGTC_2540 epiandrosterone 100 µM 0.537646379566238 0.28967158206505 no 989 0.295410602113305 1455 441302 A steroid.
SGTC_347 4534-1311 26.2 µM 0.537007324846176 0.289872141630929 no 990 0.295631277209375 1403 2862016
SGTC_512 prima-1 270 µM 0.535495545613742 0.290346854291641 no 991 0.296153618471869 1493 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2520 obtusaquinone 4.71 µM 0.535406066853136 0.290374962857308 no 992 0.296184547926961 1524 5967872
SGTC_2058 5236698 133 µM 0.533480376759305 0.290980201393861 no 993 0.296850545649238 1439 766665
SGTC_2246 7293507 91.5585 µM 0.533136419569124 0.29108836810456 no 994 0.296969574956461 1535 887656
SGTC_1631 benzylvanillin 81.9 µM 0.532418330545334 0.291314251276038 no 995 0.297218146109739 1470 75506
SGTC_2944 9067346 25.62 µM 0.529634607484197 0.292190675717497 no 996 0.298182647449007 1456 6473075
SGTC_1839 st053978 48 µM 0.528867113071188 0.292432528424711 no 997 0.298448818569625 1458 3788398
SGTC_480 am 92016 50 µM 0.528320100137963 0.292604959827393 no 998 0.298638591509344 1369 2129 K+ channel blocker.
SGTC_1051 3253-3903 78 µM 0.528305669910758 0.292609509215437 no 999 0.298643598471288 1404 5509239
SGTC_939 1165-0479 45.3 µM 0.527500434109095 0.292863426314966 no 1000 0.298923057525971 1396 1377347
SGTC_1672 st016598 6.51 µM 0.524140548008895 0.293924010037415 no 1001 0.300090393966194 1401 4665860 YNL267W PIK1
SGTC_2896 9052656 71.43 µM 0.523231340285586 0.294211316175397 no 1002 0.300406637168243 1409 6469436
SGTC_50 0929-0078 56.389 µM 0.522144379134569 0.294554961880585 no 1003 0.300784904540095 1509 1377751
SGTC_2224 6650123 117.647 µM 0.520152503988022 0.295185178792524 no 1004 0.301478643156439 1441 2908370
SGTC_744 1594-0068 283 µM 0.518082804485997 0.295840675712949 no 1005 0.30220024857265 1464 668392
SGTC_2592 piperlongumine 83.33 µM 0.517344027537468 0.296074816427956 no 1006 0.302458012435668 1390 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.514872890444488 0.296858611655748 no 1007 0.303320922950267 1525 688798
SGTC_1793 st048256 72.231 µM 0.513375367776112 0.297334057491444 no 1008 0.303844386319652 1415 672022
SGTC_2222 6885208 172.143 µM 0.51013838435891 0.298362948500679 no 1009 0.304977257691167 1452 609514
SGTC_3141 9094609 49.47 µM 0.509613205877211 0.298530031727728 no 1010 0.305161235098719 1418 25236309 YDL196W YDL196W
SGTC_305 1682-2595 20.8 µM 0.509193964582251 0.298663442046854 no 1011 0.305308136569047 1492 226033
SGTC_517 1365-0151 113 µM 0.509129758364289 0.298683876044075 no 1012 0.305330637093661 1488 768657
SGTC_2900 5328528 85.29 µM 0.505308214624087 0.299901247214172 no 1013 0.306671187024824 1429 795359
SGTC_2023 5144124 124 µM 0.502821526985504 0.300694597687181 no 1014 0.307544878592399 1457 2830192
SGTC_808 0711-0032 135 µM 0.501904676552363 0.300987347591965 no 1015 0.307867287762032 1573 4252555
SGTC_2883 9059145 45.46 µM 0.50107296018748 0.301253025325117 no 1016 0.308159888029546 1453 16476510
SGTC_2730 imipramine 71.33 µM 0.498595839405891 0.302044924680688 no 1017 0.309032068401359 1506 3696 A tricyclic antidepressant.
SGTC_1096 rimcazole 32.2 µM 0.494725394393014 0.303284117042883 no 1018 0.310396986742123 1470 18528119 A dopamine reuptake inhibitor.
SGTC_1831 st055328 12 µM 0.494283932015126 0.303425603415641 no 1019 0.310552835623996 1569 1103068
SGTC_155 k072-0202 43.6 µM 0.493574524052091 0.303653026686676 no 1020 0.310803348213583 1439 5857737
SGTC_1960 st011366 51.8 µM 0.492981082602729 0.303843331634565 no 1021 0.31101297704891 1486 3972846
SGTC_1884 5633444 25 µM 0.491597760893363 0.304287141981297 no 1022 0.311501863321315 1505 5724239
SGTC_1496 4469-0713 57.4 µM 0.491465819265474 0.304329487818409 no 1023 0.311548510820962 1546 746691
SGTC_2298 7976326 193.81 µM 0.491338088369076 0.30437048474716 no 1024 0.311593672512951 1428 2235818
SGTC_824 1304-0008 100 µM 0.49085013005906 0.304527124084033 no 1025 0.311766225561864 1501 768245
SGTC_1346 1488-2224 62.4 µM 0.489412221582951 0.304988915035768 no 1026 0.312274942631252 1524 3722427
SGTC_2032 5185112 25.99 µM 0.488393452701321 0.305316285495518 no 1027 0.312635589270497 1489 5718189
SGTC_1309 pyrazolanthrone 13.4 µM 0.487798525056033 0.305507531181802 no 1028 0.312846278120794 1597 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3288 9119690 36.221 µM 0.486729808869586 0.305851214431037 no 1029 0.313224908935872 1448 17595618 YKL019W RAM2
SGTC_2275 7947463 200 µM 0.486214809463645 0.306016891680659 no 1030 0.31340743619952 1477 1225414
SGTC_2729 fluphenazine 10.66 µM 0.485546569443802 0.306231926177959 no 1031 0.313644343481788 1432 3372 An atypical antipsychotic.
SGTC_2655 perillic acid 100 µM 0.484661512260849 0.3065168335437 no 1032 0.313958236032775 1470 5702197 An apoptosis inducer.
SGTC_2711 st079103 59.1 µM 0.484640527070361 0.30652359027376 no 1033 0.313965680232252 1599 54693780
SGTC_1306 1185-0270 9.02 µM 0.481829957502809 0.307429120064428 no 1034 0.314963373118448 1573 1548076
SGTC_1254 0550-0035 264 µM 0.48085829140939 0.307742452144124 no 1035 0.315308608888006 1601 15121435
SGTC_2816 7982706 58.44 µM 0.480667287746577 0.307804061385902 no 1036 0.31537649202415 1475 2981853
SGTC_1966 st070145 16.1 µM 0.47974694197757 0.308100999723785 no 1037 0.31570367233831 1458 3748532
SGTC_1979 st071809 45.3 µM 0.479470568617322 0.308190192758867 no 1038 0.315801950504786 1573 4976333
SGTC_3203 9113543 49.47 µM 0.479188419533911 0.308281261458497 no 1039 0.315902295949288 1554 17018012
SGTC_3078 9116413 49.47 µM 0.479121212257326 0.308302955558256 no 1040 0.315926200009361 1433 17177322
SGTC_1813 st051246 8.6015 µM 0.4790178386814 0.308336325226162 no 1041 0.31596296908069 1567 5291959
SGTC_2856 9022925 19.48 µM 0.478536827944789 0.308491619471603 no 1042 0.316134084309663 1532 4944862
SGTC_1638 st008370 60.6 µM 0.477602333065831 0.308793418944109 no 1043 0.316466635007684 1461 24207134
SGTC_2726 cimetidine 79.27 µM 0.474911264504192 0.309663233083602 no 1044 0.317425111074566 1533 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3094 9117742 49.47 µM 0.474374114353139 0.309836980044185 no 1045 0.317616574400824 1455 17149698
SGTC_1227 3909-8010 46.6 µM 0.473777481689088 0.31003001706531 no 1046 0.317829297038174 1533 15982272
SGTC_916 4466-0038 42 nM 0.473082552887742 0.310254923256694 no 1047 0.318077141866167 1566 5722064 YGL116W CDC20
SGTC_1786 berberine 21.6 µM 0.47282988212421 0.310336715017959 no 1048 0.318167276545087 1472 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1029 k015-0030 64.7 µM 0.472413525851165 0.31047151369071 no 1049 0.318315825882713 1567 2208316
SGTC_474 dl-dihydrosphingosine 5 µM 0.469863793748168 0.311297564612893 no 1050 0.319226166662461 1561 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2395 5646831 180.19 µM 0.466036525916787 0.31253929054134 no 1051 0.320594677957077 1585 6808628
SGTC_659 k018-0002 107 µM 0.463812868891185 0.313261717846335 no 1052 0.32139091126758 1622 6797879 YHR007C ERG11
SGTC_3066 9117245 49.47 µM 0.462912801200503 0.313554338180985 no 1053 0.321713435687549 1629 17176980
SGTC_2607 solasodine 47.35 µM 0.459987162545693 0.314506300418979 no 1054 0.322762717501663 1526 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2102 5377816 72.7585 µM 0.459561591315927 0.314644878398844 no 1055 0.322915466731876 1650 1379702
SGTC_695 3505-6186 243 µM 0.457037776027342 0.315467239832584 no 1056 0.323821946758167 1589 1819379
SGTC_1055 3448-0672 86 µM 0.455592494282227 0.315938583519536 no 1057 0.324341520738632 1546 748378
SGTC_2932 9016711 44.54 µM 0.45406855039367 0.316435905268753 no 1058 0.324889744158888 1675 7117328
SGTC_1726 st035556 14.5795 µM 0.452575961388768 0.316923316694415 no 1059 0.325427055839773 1645 5919439
SGTC_59 0330-0160 1.33 µM 0.451955957582312 0.317125875132902 no 1060 0.32565035554136 1559 4293482
SGTC_2 0422-0095 29 µM 0.451716953679018 0.317203973578406 no 1061 0.325736451567568 1495 6790840
SGTC_1842 st055362 61.2 µM 0.451610900984364 0.317238630643821 no 1062 0.325774657752234 1612 676032
SGTC_2046 4110841 106 µM 0.45143232514151 0.317296991242294 no 1063 0.325838995015353 1574 44119630 YMR134W ERG29
SGTC_573 3702-0553 84.7 µM 0.451267151454776 0.317350975909565 no 1064 0.325898508370278 1538 1222756
SGTC_2603 homopterocarpin 100 µM 0.45024385487467 0.317685512395625 no 1065 0.3262673088551 1548 101795 A weak amylase inhibitor.
SGTC_576 1073-0113 22.7 µM 0.450005123056121 0.317763580119278 no 1066 0.326353373290187 1629 5439563
SGTC_2844 9010103 25.97 µM 0.44962122022441 0.317889137224435 no 1067 0.326491792245666 1543 2480525
SGTC_1302 1159-0335 255 µM 0.44926479155827 0.318005727529074 no 1068 0.326620326582281 1528 649284
SGTC_3347 9188721 44.724 µM 0.448441791942827 0.31827500535085 no 1069 0.326917193081127 1572 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3323 9138564 53.9225 µM 0.448032387186418 0.318408994567474 no 1070 0.327064911444127 1671 43912313 YNL103W MET4
SGTC_174 3553-0389 74.3 µM 0.448018035881747 0.31841369186648 no 1071 0.327070090066282 1587 738071
SGTC_3110 9122132 49.47 µM 0.447635871728732 0.318538788046011 no 1072 0.327208005018637 1628 918317
SGTC_1843 st055809 45.5 µM 0.44701084336431 0.31874342706707 no 1073 0.327433615367784 1536 16413835
SGTC_852 0418-0143 439 µM 0.445039217661894 0.319389314277827 no 1074 0.328145706490236 1591 5369229
SGTC_1749 st037932 54.2 µM 0.445002215975679 0.319401440952781 no 1075 0.328159076354417 1543 594497
SGTC_699 0375-0592 111 µM 0.443851691720198 0.319778602089201 no 1076 0.328574906451221 1614 762578
SGTC_1626 st003712 1.76 µM 0.441993285057317 0.320388212584345 no 1077 0.329247032538291 1605 24207035
SGTC_1057 3448-5381 134 µM 0.441531227097929 0.320539856143532 no 1078 0.329414229888187 1670 5497911
SGTC_247 mechlorethamine 29.705 µM 0.441517426410956 0.320544385874545 no 1079 0.329419224241679 1579 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3286 9117135 37.221 µM 0.441197219264887 0.320649493380936 no 1080 0.329535113079613 1503 3438150
SGTC_1605 st000082 49.1 µM 0.439877736055597 0.321082763389745 no 1081 0.330012830890574 1618 1114022
SGTC_1522 st012842 45.6 µM 0.438903618219214 0.32140278445278 no 1082 0.330365687450859 1470 3491067 YOR116C RPO31
SGTC_1809 st050081 57.6 µM 0.438856502622575 0.321418266420106 no 1083 0.330382758051072 1628 5036894
SGTC_2610 ononetin 44.17 µM 0.438662312248878 0.321482079753848 no 1084 0.330453119502084 1524 259632
SGTC_594 1487-1584 10.8 µM 0.438329398111857 0.321591491672458 no 1085 0.330573759002786 1515 5013332
SGTC_2902 5787006 60.46 µM 0.43732730869175 0.321920920797373 no 1086 0.330936996585765 1540 591003
SGTC_954 1189-0853 2.85 µM 0.436250963132673 0.322274917006794 no 1087 0.331327327896748 1561 2828194
SGTC_1794 st048918 76.9 µM 0.436195602617548 0.322293128730885 no 1088 0.331347409069693 1640 672303
SGTC_398 bronopol 33.3 µM 0.436082668540076 0.322330281518874 no 1089 0.331388375667902 1608 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_334 1502-1024 68.5 µM 0.433445210150112 0.323198450464083 no 1090 0.332345680999746 1588 3296216
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.433188584897096 0.323282975011115 no 1091 0.332438885551494 1669 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_484 loperamide 105 µM 0.430260946421011 0.324247894805102 no 1092 0.333502916158813 1582 3955 An opioid-receptor agonist.
SGTC_1915 st067105 30.6 µM 0.429804257792851 0.324398521417392 no 1093 0.333669017694168 1517 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1676 st018489 23.4 µM 0.428719676936151 0.324756356726002 no 1094 0.334063619587882 1591 3696235
SGTC_3319 9138450 16.7555 µM 0.426406419452374 0.325520109007626 no 1095 0.334905862259089 1571 2029690
SGTC_3092 9117248 49.47 µM 0.425478056833454 0.325826826446888 no 1096 0.335244107247899 1680 17141857
SGTC_1447 4239-0816 81.9 µM 0.424533384425495 0.326139053455259 no 1097 0.335588431812462 1537 1341554
SGTC_466 geldanamycin 89.2 µM 0.423994153886387 0.326317331113844 no 1098 0.335785038412837 1650 5288382 HSP90 inhibitor.
SGTC_3170 9103054 49.47 µM 0.423630114898226 0.326437710277541 no 1099 0.335917794574139 1544 16432970
SGTC_2852 9023854 51.95 µM 0.421796475736139 0.327044326437018 no 1100 0.336586789162561 1660 19798528
SGTC_729 4092-0585 94.1 µM 0.420477136866962 0.327481081482433 no 1101 0.337068464029127 1541 2169061
SGTC_433 pimozide 108 µM 0.42035679965891 0.327520929776885 no 1102 0.337112411018549 1500 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1758 st042942 75.2445 µM 0.420300436430578 0.32753959449307 no 1103 0.337132995559588 1597 669317
SGTC_1490 4089-0339 670 nM 0.417675109679889 0.32840944993257 no 1104 0.338092336469763 1690 742542
SGTC_1428 4049-0204 61.7 µM 0.415795567453264 0.329032775062826 no 1105 0.338779801321616 1694 X1428
SGTC_2860 9025725 38.96 µM 0.414726364362484 0.329387574412143 no 1106 0.339171114993195 1545 40546248
SGTC_1354 1498-1681 81 µM 0.412468398828675 0.330137351762555 no 1107 0.339998069244163 1625 5754243
SGTC_2565 isoliquiritigenin 100 µM 0.412233124679029 0.330215515941107 no 1108 0.340084280118142 1519 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1720 st037298 9.481 µM 0.412157084099404 0.330240780179807 no 1109 0.340112145251441 1589 597396
SGTC_3051 9093778 49.47 µM 0.411857191083907 0.330340426216767 no 1110 0.340222049807727 1625 17217378
SGTC_3316 9136639 10.545 µM 0.408818626648028 0.331350733472163 no 1111 0.341336384709169 1684 4903665
SGTC_1009 4106-0057 9.87 µM 0.407748697729826 0.331706772272772 no 1112 0.341729090672255 1650 2928005
SGTC_1107 amlodipine 47 µM 0.406236639696425 0.332210197059795 no 1113 0.342284367517146 1563 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1763 st044482 94.5 µM 0.404851169626089 0.332671741636594 no 1114 0.342793456709963 1671 88505
SGTC_1394 3474-0001 65.7 µM 0.404798106238294 0.332689423804685 no 1115 0.342812960468023 1587 5017666 YIL048W NEO1
SGTC_2990 9074105 71.4286 µM 0.404691802359622 0.332724848276111 no 1116 0.342852034339699 1618 6502001
SGTC_492 tmb-8 126 µM 0.404481411577118 0.332794962841793 no 1117 0.342929372150104 1678 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1259 0671-0132 43 µM 0.404447642087859 0.332806217363712 no 1118 0.342941786131883 1602 X1259
SGTC_2082 5219693 150 µM 0.402030361612991 0.333612227001203 no 1119 0.343830840893859 1584 2834649
SGTC_802 4112-3352 742 µM 0.401330447046068 0.333845747745143 no 1120 0.344088424964929 1719 704594
SGTC_568 1193-0097 7.48 µM 0.40044172955222 0.334142353777583 no 1121 0.344415596961689 1624 3646150
SGTC_1567 st069303 68.4 µM 0.400028301663478 0.334280369061632 no 1122 0.344567835791093 1619 5581319
SGTC_176 1486-1328 72.834 µM 0.399207275963686 0.334554519783458 no 1123 0.344870241241091 1583 22310231
SGTC_837 0091-0265 12.5 µM 0.399038747886739 0.334610804330051 no 1124 0.344932326851221 1605 759367
SGTC_2679 rapamycin 1 nM 0.398651196146947 0.33474025190086 no 1125 0.345075116444008 1646 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_123 0083-0120 66.675 µM 0.398612648099028 0.334753128549271 no 1126 0.345089320296401 1557 16001701
SGTC_2139 5578692 56.4705 µM 0.396080834938307 0.335599284140754 no 1127 0.346022698064218 1740 650991 YMR113W FOL3
SGTC_54 0159-0055 9 µM 0.393929972019222 0.336318778361139 no 1128 0.346816370691517 1739 3319099
SGTC_2035 5154463 94.595 µM 0.393788897966914 0.336365990628581 no 1129 0.34686845083667 1704 2769623
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.39346348439391 0.336474904355525 no 1130 0.346988594422917 1779 688664
SGTC_653 0203-0016 55.2 µM 0.393152880262195 0.336578874262014 no 1131 0.347103284672583 1676 295302
SGTC_282 k297-0036 65.7 µM 0.391867365755441 0.337009313056933 no 1132 0.347578108393724 1678 5061378
SGTC_966 1300-0360 30.2 µM 0.389908792148291 0.337665527781427 no 1133 0.348301996131528 1644 70588
SGTC_660 4031-1742 102 µM 0.387306494748639 0.338538184201083 no 1134 0.349264658961712 1643 6738706
SGTC_638 3970-0837 4.09 µM 0.385008695235123 0.339309451656622 no 1135 0.350115486666675 1613 4118451 YLR208W SEC13
SGTC_2312 7706453 155.7 µM 0.384129229022403 0.339604827171531 no 1136 0.350441334317375 1640 976098
SGTC_1186 1319-0216 26 µM 0.383524422861526 0.339808013185378 no 1137 0.350665482631435 1815 4565136
SGTC_930 2810-3379 265 µM 0.382457235661355 0.340166650678881 no 1138 0.351061121607927 1784 1015764
SGTC_29 0299-0004 12.984 µM 0.382198664932303 0.340253567391635 no 1139 0.351157006017927 1627 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1240 0356-0016 42.1 µM 0.381000565373205 0.340656410763078 no 1140 0.351601414508018 1694 4305613
SGTC_3138 9097216 49.47 µM 0.380820577499375 0.340716944760897 no 1141 0.351668194566812 1660 25237486
SGTC_3155 9099265 49.47 µM 0.380613292018169 0.340786664644933 no 1142 0.351745108400516 1687 25236499
SGTC_2525 harmine 47.85 µM 0.380445047897618 0.340843257076897 no 1143 0.351807540294378 1727 5280953 A monoamine oxidase inhibitor
SGTC_1207 2099-0101 141 µM 0.380291307428878 0.340894974034081 no 1144 0.351864593679095 1770 5837381
SGTC_315 k915-0449 187 µM 0.380070236579845 0.340969345586876 no 1145 0.351946639344657 1716 20970215 YNL149C PGA2
SGTC_2328 6201408 200 µM 0.379576852102087 0.341135349817078 no 1146 0.352129773182441 1633 2890418
SGTC_2576 guaiol 23.12 µM 0.378810048291113 0.341393409797083 no 1147 0.352414462533815 1826 227829
SGTC_1220 1838-0075 193 µM 0.378270368020704 0.341575078155036 no 1148 0.352614877888042 1698 5529645
SGTC_13 0199-0087 65 µM 0.377525623438272 0.3418258359833 no 1149 0.352891512990087 1701 4589825
SGTC_1000 4048-0884 8.67 µM 0.375633665698741 0.34246317775868 no 1150 0.3535946295189 1690 13040088
SGTC_1386 3228-0095 33.8 µM 0.375179466412348 0.342616250264725 no 1151 0.35376350007362 1749 870181
SGTC_348 k064-0012 10.7 µM 0.373648887536882 0.34313227029608 no 1152 0.354332778527024 1621 5066323
SGTC_82 0054-0107 293.755 µM 0.371760657913427 0.343769272032602 no 1153 0.355035528995887 1782 3104697
SGTC_152 4469-0003 551.229 µM 0.370672675726385 0.34413650878348 no 1154 0.355440672190874 1724 697280
SGTC_2782 7736369 71.43 µM 0.368497608290134 0.34487112007799 no 1155 0.356251114092298 1653 2950836 YOL077C BRX1
SGTC_2068 5226020 147 µM 0.367899691611881 0.345073164222715 no 1156 0.356474015095536 1640 1810509
SGTC_1946 st076057 65.1 µM 0.367838236375806 0.345093933283898 no 1157 0.3564969281479 1634 953009
SGTC_2126 5251174 33.877 µM 0.367571217308655 0.345184178943004 no 1158 0.356596489907345 1855 790722
SGTC_2289 7946404 165.07 µM 0.36718759910376 0.345313847557681 no 1159 0.356739544374453 1635 1246120 YPR165W RHO1
SGTC_839 0122-0028 230 µM 0.36704710731136 0.345361340400673 no 1160 0.356791939992384 1693 759448
SGTC_783 0848-0141 92.7 µM 0.366926620063738 0.345402072704909 no 1161 0.356836877180977 1649 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2324 6149169 200 µM 0.366836614869841 0.345432501316923 no 1162 0.356870447012238 1750 2888231
SGTC_1323 1348-1351 11.2 µM 0.36433191284824 0.34627968148373 no 1163 0.357805086019582 1662 6989654
SGTC_1321 1326-2144 215 µM 0.364062233994842 0.346370942529313 no 1164 0.357905768673437 1761 3513030
SGTC_960 1222-0186 7.7 µM 0.363458891943454 0.346575149625356 no 1165 0.358131057863332 1742 3126296
SGTC_1171 0368-0077 21.4 µM 0.363409933979629 0.346591721890151 no 1166 0.358149341038171 1659 3239779
SGTC_3032 9089427 49.47 µM 0.361630732376261 0.347194180402308 no 1167 0.358813997867594 1651 17173707
SGTC_489 paxilline 115 µM 0.360093752157433 0.347714931036753 no 1168 0.359388512447678 1656 105008 A toxic potassium channel blocker.
SGTC_2826 7992541 19.48 µM 0.359142152279858 0.34803749068064 no 1169 0.359744374637243 1724 2985066
SGTC_797 k781-0471 270 µM 0.357484734008418 0.348599560988361 no 1170 0.360364476350221 1751 23738129
SGTC_9 0092-0002 10.449 µM 0.356975344073255 0.348772374200861 no 1171 0.360555131941075 1695 759368
SGTC_2176 5809774 33.9695 µM 0.354503545428105 0.34961138988763 no 1172 0.361480773735927 1826 2870539
SGTC_3220 9131269 49.47 µM 0.353016419521621 0.350116527374949 no 1173 0.362038065512109 1693 17722206
SGTC_2995 9067767 71.4286 µM 0.351051827760848 0.350784254094996 no 1174 0.362774733324549 1708 11673567
SGTC_2967 9089538 49.85 µM 0.350863473156845 0.350848296438305 no 1175 0.362845387853209 1881 728216
SGTC_1488 4013-0813 75.9 µM 0.350498906483524 0.350972264586429 no 1176 0.362982155334274 1701 2910057
SGTC_1710 st031758 61.5 µM 0.350429695981007 0.350995800888018 no 1177 0.363008121684429 1780 5394341
SGTC_2127 5253358 187.912 µM 0.345699824374828 0.352605630742894 no 1178 0.364784158131746 1655 20612
SGTC_2427 5545055 42.75 µM 0.34525365600348 0.352757622726001 no 1179 0.364951842049528 1743 5372858
SGTC_2326 6164455 177.58 µM 0.344857235619661 0.352892687250941 no 1180 0.36510085080327 1695 2888790
SGTC_977 1348-1378 135 µM 0.344722702659898 0.3529385282363 no 1181 0.365151424450139 1689 X977
SGTC_215 1287-0124 461.5 µM 0.342701385088196 0.353627532012009 no 1182 0.365911560304542 1824 5560863
SGTC_763 3453-1109 128 µM 0.34253243313801 0.353685144193228 no 1183 0.365975120196931 1834 1560353
SGTC_2418 pentamidine 31.67 µM 0.341605365029357 0.354001331654954 no 1184 0.366323949571406 1644 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1510 1123-0200 71.5 µM 0.34033061118364 0.354436265828234 no 1185 0.366803783565897 1828 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1401 3807-4679 7.6 µM 0.3388104878187 0.354955166014386 no 1186 0.367376249983364 1701 3291456
SGTC_1768 st044301 37.178 µM 0.335359986320928 0.356134006088506 no 1187 0.368676774140119 1682 3931349
SGTC_1237 0330-0133 46.1 µM 0.334891807454736 0.356294062473761 no 1188 0.36885335116644 1719 X1237 YHR072W ERG7
SGTC_53 0973-0023 39.979 µM 0.334863813719265 0.356303633499174 no 1189 0.368863910082685 1911 674768
SGTC_848 0368-0089 85.6 µM 0.334455738723685 0.356443164137511 no 1190 0.369017842529316 1793 762535
SGTC_2281 7943571 200 µM 0.334110920617046 0.356561080708234 no 1191 0.369147929839394 1895 1244024
SGTC_2854 9024559 71.43 µM 0.332657895503711 0.357058118519974 no 1192 0.369696267767509 1670 3163529
SGTC_2713 st079149 53.4 µM 0.332225989223365 0.3572059079809 no 1193 0.369859310325456 1754 3103253
SGTC_1921 5740136 50 µM 0.331490006095985 0.357457795645655 no 1194 0.370137194329538 1881 1774243
SGTC_2170 morpholine 200 µM 0.33103420109116 0.357613824474854 no 1195 0.370309325923509 1797 121171 Reacts with secondary amines.
SGTC_1514 1189-1591 158 µM 0.330151398588005 0.357916088561767 no 1196 0.370642783999429 1803 767698 YMR146C TIF34
SGTC_212 3807-4682 38.772 µM 0.32909745841613 0.358277065411878 no 1197 0.371041012617714 1826 3125501 YBL034C STU1
SGTC_971 1315-0384 26.7 µM 0.327497079721179 0.358825440858403 no 1198 0.371645975671297 1687 6769120
SGTC_844 0330-0132 15.3 µM 0.326938046844712 0.359017064123732 no 1199 0.371857371865983 1817 2828079
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.326619418955147 0.359126298115289 no 1200 0.371977877104408 1712 279621
SGTC_1891 st059073 26.2 µM 0.325795097069893 0.359408950687294 no 1201 0.372289694250249 1877 688754
SGTC_2416 tofa 880 nM 0.325212907830253 0.35960862452337 no 1202 0.372509970089391 1615 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2099 5377090 177.372 µM 0.324137315866912 0.359977621820293 no 1203 0.372917038359874 1719 2243829
SGTC_313 3474-0040 5.03 µM 0.323846210662018 0.360077512106375 no 1204 0.373027234389028 1709 1043375 YIL048W NEO1
SGTC_1498 4478-3555 97.6 µM 0.322894120813422 0.360404280373431 no 1205 0.37338771447315 1863 3437919
SGTC_2071 5230951 39.92 µM 0.320837501548121 0.361110483755744 no 1206 0.374166769194402 1820 1799272
SGTC_3231 9132313 49.47 µM 0.31614178022782 0.362724675893465 no 1207 0.375947447838331 1775 4905967
SGTC_1816 st051957 91.6 µM 0.315447143693474 0.362963670898421 no 1208 0.376211088517999 1765 674121
SGTC_731 3966-0296 387 µM 0.311756527571322 0.364234348759051 no 1209 0.377612782250489 1762 660956
SGTC_2799 7812892 81.82 µM 0.311594616308511 0.364290129056064 no 1210 0.377674313124142 1859 20205235
SGTC_2414 st077232 92.9 µM 0.311592383763278 0.364290898213734 no 1211 0.377675161576374 1656 729801
SGTC_620 0109-0052 432 µM 0.311372254535644 0.364366739935368 no 1212 0.377758821965697 1860 493037
SGTC_2076 5212012 200 µM 0.310520711108716 0.364660174491288 no 1213 0.378082506078984 1768 604802
SGTC_3087 9117406 49.47 µM 0.309550243003094 0.364994686163134 no 1214 0.378451499557695 1764 42546093
SGTC_1853 st056710 91.2 µM 0.307970989259985 0.365539260407224 no 1215 0.379052203685628 1917 269167
SGTC_2555 cholic acid 100 µM 0.307429527221258 0.365726035297752 no 1216 0.379258228102721 1806 6708657 Influences liver metabolism.
SGTC_1092 toremifene 6.32 µM 0.305587634450905 0.36636162601012 no 1217 0.379959318325849 1800 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2376 9072922 81.32 µM 0.302771746827624 0.367334026231792 no 1218 0.381031908080754 1801 17087968
SGTC_1497 4476-2978 41.3 µM 0.300053447850309 0.368273534367585 no 1219 0.382068193615611 1812 1528379
SGTC_3158 9100007 49.47 µM 0.299104472401562 0.368601708546149 no 1220 0.382430166963168 1727 19297233
SGTC_499 genistein 192 µM 0.297922998840916 0.369010419039181 no 1221 0.382880967019547 1847 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2941 9056145 11.23 µM 0.296929885484493 0.369354084184125 no 1222 0.383260019625763 1871 2119517
SGTC_2583 asiatic acid 100 µM 0.295937201458113 0.369697705124518 no 1223 0.383639020085791 1808 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1479 0549-0158 134 µM 0.294129637017255 0.370323666830221 no 1224 0.384329422466867 1776 5440202
SGTC_3321 9137793 26.8275 µM 0.292686013439932 0.370823842241215 no 1225 0.384881080812966 1794 4904192
SGTC_1405 3909-7894 12 µM 0.291839735446389 0.371117155605501 no 1226 0.385204581277147 1883 7104060
SGTC_1622 st003707 19.4 µM 0.290989582121481 0.371411887532451 no 1227 0.385529643592346 1829 10140899
SGTC_1274 0865-0114 173 µM 0.290831734313032 0.371466618659963 no 1228 0.385590006710477 1807 870624
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.29034711594824 0.371634668328291 no 1229 0.385775348578556 1797 2346 DNA damaging agent; causes G2/M arrest.
SGTC_126 0417-1624 672.48 µM 0.290061667117544 0.371733664021606 no 1230 0.385884530441068 1935 41912 YDL195W SEC31
SGTC_1054 3429-0080 167 µM 0.28916106723387 0.372046054063974 no 1231 0.386229061809939 1867 1162877
SGTC_2014 4013930 200 µM 0.288860326580015 0.372150390400189 no 1232 0.386344132444125 1931 64556
SGTC_1429 4049-0205 9.46 µM 0.288536304619565 0.372262814254769 no 1233 0.386468122255603 1825 22774478
SGTC_1765 st044815 90.4 µM 0.284518992696672 0.373657577143611 no 1234 0.388006340566844 1738 645695
SGTC_2952 9073731 13.78 µM 0.284433521340527 0.373687269840322 no 1235 0.388039086520438 1748 16457353
SGTC_2940 9060638 45.86 µM 0.283159891758539 0.374129816713887 no 1236 0.388527136179578 1816 4027022
SGTC_206 4546-0025 72.014 µM 0.282959838099466 0.374199344264143 no 1237 0.388603811941549 1824 6620745 YIL048W NEO1
SGTC_2070 5230947 200 µM 0.282435913073996 0.374381450914754 no 1238 0.388804640380246 1922 2835538
SGTC_3127 9126946 49.47 µM 0.281231994885476 0.374800016754734 no 1239 0.389266233078264 1733 27243249
SGTC_2268 7933382 153.85 µM 0.280102474758281 0.375192850798955 no 1240 0.389699443046162 1920 935025 YOR257W CDC31
SGTC_2784 7567673 72.73 µM 0.277113846062137 0.376232884893334 no 1241 0.390846345192881 1804 3471247
SGTC_459 nigericin 15.3 µM 0.27701364171612 0.376267771338921 no 1242 0.39088481566036 1837 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_791 1348-1292 225 µM 0.276409325158839 0.376478187396184 no 1243 0.391116847590546 1907 5437054
SGTC_1896 st058441 89 µM 0.27640905489374 0.376478281507592 no 1244 0.39111695136956 1783 688759
SGTC_8 0354-0001 70 µM 0.274213391127508 0.377243094939624 no 1245 0.391960318885849 1835 4993152
SGTC_2202 7226349 200 µM 0.273059664196513 0.377645164803358 no 1246 0.392403676070766 1830 844334
SGTC_285 1486-1325 46 µM 0.272996259383366 0.377667265010772 no 1247 0.392428045491759 1906 22310230
SGTC_1994 st072947 40.9 µM 0.270184529562569 0.37864771551861 no 1248 0.393509146937966 1868 5286565 YDL195W SEC31
SGTC_2248 tofa 1.1 µM 0.269425578151847 0.378912496181773 no 1249 0.393801102562181 1846 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2911 7942208 15.64 µM 0.268915398283443 0.379090518136692 no 1250 0.393997393596633 1800 1243384
SGTC_2081 5214970 32.255 µM 0.268432681360775 0.379258980797123 no 1251 0.394183143095993 1929 2063512
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.268177948007206 0.379347889056241 no 1252 0.394281174210096 1820 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1040 k898-0338 155 µM 0.26774846172079 0.379497804870938 no 1253 0.3944464720822 2012 20969351
SGTC_2072 5231554 129 µM 0.267287056853852 0.379658882323878 no 1254 0.394624075748988 1992 789545
SGTC_629 3448-6466 76.7 µM 0.266123409660315 0.380065206814679 no 1255 0.395072083286769 1845 573744
SGTC_1194 1488-0194 225 µM 0.264134230581943 0.38076009849632 no 1256 0.395838244016039 1848 1391452
SGTC_391 gliotoxin 8.33 µM 0.261839655570516 0.381562153835826 no 1257 0.396722532299172 1891 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2217 6934799 96.0675 µM 0.258755512327145 0.382640999233887 no 1258 0.397911942533779 1935 675606
SGTC_2007 4011539 71.82 µM 0.258179779900949 0.382842493887406 no 1259 0.398134081177182 1798 45595301
SGTC_3076 9116187 49.47 µM 0.257624074133635 0.383037009694208 no 1260 0.398348524122009 1976 27241210
SGTC_3153 9100258 49.47 µM 0.257443627243329 0.383100178553312 no 1261 0.398418163913538 1783 25236848
SGTC_1012 4112-3522 18 µM 0.257160630981373 0.383199253026718 no 1262 0.398527387055084 1952 3112398
SGTC_1421 4029-0249 71.4 µM 0.256671812455582 0.383370402035657 no 1263 0.398716066552117 1988 2894095
SGTC_2355 9061122 103.12 µM 0.254120161613893 0.384264175044547 no 1264 0.39970136390399 1946 5302957
SGTC_1664 st014217 9.02 µM 0.254045699008871 0.384290266513315 no 1265 0.399730126605238 1965 3982782
SGTC_2365 9042475 200 µM 0.253809064658886 0.384373185944935 no 1266 0.39982153506481 1844 6464479
SGTC_1204 4049-0315 18.3 µM 0.252452859789811 0.384848517880626 no 1267 0.400345523332166 1953 588402
SGTC_1799 st045822 46.1415 µM 0.249431068652176 0.385908237512822 no 1268 0.401513677563533 1972 3674992
SGTC_1282 0886-0010 32.4 µM 0.248828366704965 0.386119702755105 no 1269 0.401746773808262 1991 2836211 YNL267W PIK1
SGTC_1963 st076565 50.3 µM 0.248008975928667 0.386407250146196 no 1270 0.402063730970805 1829 4914280
SGTC_720 r052-1644 49.9 µM 0.247720198160589 0.38650860530723 no 1271 0.40217545149806 1861 1422863 YOR257W CDC31
SGTC_73 0327-0325 16.231 µM 0.247693152653634 0.386518098130297 no 1272 0.402185915103193 2015 53298
SGTC_2723 salbutamol 83.58 µM 0.247097083836924 0.386727332214493 no 1273 0.402416545267063 1948 9884233 β2-adrenoceptor agonist
SGTC_634 1611-4317 11.2 µM 0.246584420305166 0.386907315437744 no 1274 0.402614931544149 2008 2843522
SGTC_2796 7949634 45.45 µM 0.2462084641407 0.387039319616519 no 1275 0.402760431882292 1837 2971588
SGTC_600 1495-0418 41.6 µM 0.244573468623747 0.387613544287432 no 1276 0.403393354609221 1877 5377768
SGTC_1694 st024011 44.9 µM 0.243335999658235 0.388048317743889 no 1277 0.40387255931479 1924 2787533
SGTC_274 sirtinol 40.1 µM 0.243259577033872 0.388075172744582 no 1278 0.403902158396644 1805 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2571 chrysanthemic acid 100 µM 0.24121550530395 0.388793660194583 no 1279 0.404694047082177 1796 2743 An insecticide.
SGTC_2845 9003024 42.97 µM 0.241022673432378 0.388861459923646 no 1280 0.404768771800242 1959 2990173
SGTC_1300 1094-0077 113 µM 0.239875443098879 0.389264896274573 no 1281 0.405213409348127 1847 5532636
SGTC_375 3970-0961 9.27 µM 0.238521675946252 0.389741117153054 no 1282 0.405738252724861 1900 2898222
SGTC_2077 5212015 200 µM 0.238182424443609 0.389860483183642 no 1283 0.40586980408416 1956 780900
SGTC_3045 9092950 49.47 µM 0.237959830275345 0.389938808842038 no 1284 0.405956125072812 2016 44120432
SGTC_3054 9094397 49.47 µM 0.237458477889241 0.390115239332887 no 1285 0.406150563949552 1847 2598354
SGTC_859 0439-0102 54.6 µM 0.236608094767101 0.390414548677553 no 1286 0.406480419894538 2016 610143
SGTC_1999 st074831 12.5 µM 0.236136944917748 0.390580407265253 no 1287 0.406663203262302 1864 17112523
SGTC_592 k241-0073 46.5 µM 0.236023768100172 0.390620251796946 no 1288 0.406707113427729 2000 4230158
SGTC_1187 1391-0724 117 µM 0.234924591462572 0.391007282767969 no 1289 0.407133631202437 1907 6997986
SGTC_1570 verbenone 133 µM 0.234570306916098 0.391132052890218 no 1290 0.407271129106424 2018 29025 A natural terpanoid with antifungal properties.
SGTC_1003 4049-0218 100 µM 0.23296436257245 0.391697766504975 no 1291 0.407894539488065 1954 295161
SGTC_102 gallobenzophenone 83.616 µM 0.230866860486172 0.392436982225163 no 1292 0.408709118394827 1989 70837
SGTC_2908 7930301 100 µM 0.229241322416987 0.393010132426492 no 1293 0.409340678477137 1916 2223178
SGTC_1366 1683-0113 21.9 µM 0.228082442390298 0.393418884916123 no 1294 0.409791074663248 1870 708623
SGTC_776 4476-4378 112 µM 0.227932930889521 0.393471628189471 no 1295 0.409849190664309 1868 2892008
SGTC_411 enrofloxacin 100 µM 0.227453410641978 0.393640802056538 no 1296 0.410035596365487 2056 71188 A bacterial gyrase inhibitor.
SGTC_1930 st074634 34.3 µM 0.227192663236713 0.393732801693983 no 1297 0.410136966217076 1798 684253 YOR116C RPO31
SGTC_3266 9136860 49.47 µM 0.227041981710611 0.393785969437012 no 1298 0.410195548882309 1893 4871271 YPR165W RHO1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.226501583189083 0.393976664495526 no 1299 0.410405664009411 1991 6710655
SGTC_2337 9009472 200 µM 0.225999227597399 0.394153957822239 no 1300 0.410601010538316 2005 5742383
SGTC_2678 equilin 100 µM 0.225669404490748 0.394270372231145 no 1301 0.410729277966056 2017 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.222233740405036 0.395483584502801 no 1302 0.412065964856307 1888 229346 A bile salt which induces apoptosis.
SGTC_368 fentichlor 4.58 µM 0.220666634952671 0.39603730292349 no 1303 0.412676006249446 1872 7329 A pesticide.
SGTC_1699 st031318 29.054 µM 0.22061688358279 0.396054885431725 no 1304 0.412695376880818 1979 5340658
SGTC_3304 9125678 46.087 µM 0.218829911802664 0.396686554638161 no 1305 0.413391272639907 1887 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3225 9130819 49.47 µM 0.218750516184381 0.396714626169244 no 1306 0.413422197799195 1989 4547121
SGTC_1662 st014054 52 µM 0.218140327421878 0.396930385562739 no 1307 0.413659888584346 2024 2838777
SGTC_3157 9099274 49.47 µM 0.217641735809837 0.397106708245544 no 1308 0.413854131701176 2040 17217662
SGTC_1826 st055655 41.6 µM 0.217461127864563 0.397170583900536 no 1309 0.413924498798512 1918 676168
SGTC_2537 larixol 68.93 µM 0.216994038875733 0.397335792161443 no 1310 0.414106495277452 1935 6708759
SGTC_402 epigallocatechin gallate 10 µM 0.216249910005171 0.397599026804663 no 1311 0.414396475620431 1889 65064 An antioxidant.
SGTC_1322 1348-1070 12 µM 0.215507838208807 0.397861580204561 no 1312 0.414685700813618 2009 6758089
SGTC_2103 5378138 10 µM 0.213177443738115 0.398686400402566 no 1313 0.415594280594469 1971 244142
SGTC_574 1315-0397 40 µM 0.212594323192817 0.398892861140916 no 1314 0.415821699834341 1991 6794277
SGTC_153 4077-0274 519.67 µM 0.211715543812518 0.39920405682352 no 1315 0.416164480387231 2048 3121976
SGTC_3307 9126885 69.2785 µM 0.211276652757202 0.399359502088162 no 1316 0.416335700061353 1866 24824909
SGTC_2673 kobusone 100 µM 0.209704612901024 0.399916413750968 no 1317 0.416949112507318 1982 6710676 An epoxy ketone and protein crosslinker.
SGTC_365 0121-0052 13.6 µM 0.208172469323786 0.400459387702202 no 1318 0.417547151992801 1973 3101739
SGTC_363 0455-0021 3.06 µM 0.208105463264735 0.400483138273268 no 1319 0.417573310739094 1934 4597466
SGTC_397 arbidol 50 µM 0.208079481937919 0.400492347559587 no 1320 0.417583453784701 2020 131410 A RNA synthesis inhibitor.
SGTC_2047 4141938 200 µM 0.207506066381317 0.400695613303065 no 1321 0.417807327745553 1927 3807862
SGTC_74 000s-0487 160.283 µM 0.207458955848117 0.400712314355847 no 1322 0.417825721912145 2080 677548
SGTC_2518 prenyletin 46.28 µM 0.20727040990697 0.400779157184297 no 1323 0.417899340909329 2041 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_447 ml7 120 µM 0.206754679159654 0.400962007575839 no 1324 0.418100726046733 2065 4216 Selective myosin light chain kinase inhibitor.
SGTC_1230 0170-0365 3.77 µM 0.204458728505969 0.401776291002882 no 1325 0.418997520299395 2059 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1771 st048882 4.1505 µM 0.203456056611188 0.402132033348476 no 1326 0.419389294528714 1851 4580403
SGTC_3255 9139072 49.47 µM 0.20344502947373 0.402135946166103 no 1327 0.419393603609822 1949 17646060
SGTC_42 0133-0086 60.653 µM 0.202228949402264 0.402567514396705 no 1328 0.419868871152956 1944 162923 Model of phenazepam hydroxylation.
SGTC_1023 4482-3888 16 µM 0.201433518255685 0.402849865035164 no 1329 0.420179804262882 2045 3303168
SGTC_552 k242-0005 476 µM 0.200450120737097 0.403199007290934 no 1330 0.420564282063818 1943 4088318
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.199260725840714 0.403621389291581 no 1331 0.42102939966596 2002 16486 A toxic proline analog.
SGTC_1408 3909-7976 48.8 µM 0.199020303992702 0.403706782400105 no 1332 0.421123431000471 1969 24152374
SGTC_420 mitomycin C 81.9 mM 0.19803773381765 0.404055819659409 no 1333 0.421507770512804 1931 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2031 5180455 200 µM 0.194236392096002 0.405406882998355 no 1334 0.422995394344528 1993 29949
SGTC_1154 4088-0362 150 µM 0.194077711473286 0.405463305501886 no 1335 0.423057516736636 2031 6618304
SGTC_10 0279-0212 42.575 µM 0.19331235727197 0.405735472159297 no 1336 0.423357174578027 2017 39851 YBR002C RER2
SGTC_2942 9052777 62.25 µM 0.193066417991287 0.405822940003274 no 1337 0.423453476191527 1956 6469503
SGTC_1784 st039334 36.3 µM 0.190825693129549 0.406620065642078 no 1338 0.424331079178628 2077 3496984
SGTC_559 1550-0661 158 µM 0.188402075815255 0.407482689977889 no 1339 0.425280736285533 2000 5830875
SGTC_2417 cerulenin 830 nM 0.18828374815297 0.407524817195274 no 1340 0.425327112305533 2112 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1303 1160-0052 261 µM 0.188171280667688 0.407564859053727 no 1341 0.425371192511079 2081 3562476
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.188091661385761 0.407593206532787 no 1342 0.425402398843615 1921 4174840
SGTC_618 k072-0232 33.2 µM 0.18742823289744 0.407829430994463 no 1343 0.425662444084354 1987 5872756 YGL099W LSG1
SGTC_2360 9040895 200 µM 0.187154873601932 0.40792677475417 no 1344 0.425769602625574 1941 4914414
SGTC_179 1273-0063 6.77 µM 0.186742952247629 0.408073471457641 no 1345 0.425931088706941 1949 3108139
SGTC_781 4335-2806 94.4 µM 0.185281670520309 0.408593978517115 no 1346 0.426504056963159 2079 845254
SGTC_377 3970-0964 33.1 µM 0.184502435622929 0.408871607183796 no 1347 0.426809658303803 2009 16481235
SGTC_1445 4239-0156 97.7 µM 0.184248420753193 0.408962118422688 no 1348 0.426909287685945 2073 4008346
SGTC_2279 7948423 32.93 µM 0.184170813676671 0.408989772546393 no 1349 0.426939727562887 2100 1247112
SGTC_1417 3966-0327 90.4 µM 0.183879354568892 0.409093633694817 no 1350 0.427054050652752 1983 651118
SGTC_3249 9135183 49.47 µM 0.183559217145642 0.409207721686174 no 1351 0.427179629700891 2026 4902779
SGTC_1920 st075728 45.7 µM 0.181418571999263 0.40997078472573 no 1352 0.428019521200829 2117 3400306
SGTC_963 1269-2853 151 µM 0.180698064741874 0.410227696523011 no 1353 0.428302288947243 1934 3668223
SGTC_1912 st060209 90.8 µM 0.18046499022179 0.410310812328472 no 1354 0.428393768442507 1937 688787
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.179572293209291 0.410629190801117 no 1355 0.428744178937674 1952 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3289 9119912 71.43 µM 0.176748087893084 0.4116368245258 no 1356 0.429853133392995 2010 17014829
SGTC_1208 2323-2347 50.3 µM 0.176311552606008 0.41179262590236 no 1357 0.430024593269561 2125 5412760
SGTC_1574 spiramycin 23.7 µM 0.176023205198242 0.411895545997313 no 1358 0.430137855983324 2057 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2421 5690543 90.72 µM 0.175257728202993 0.41216879776167 no 1359 0.430438562818038 1989 3397993
SGTC_876 0720-0963 56.8 µM 0.173373050709807 0.412841750950441 no 1360 0.431179103366099 2124 765861
SGTC_1623 st003709 20.3 µM 0.172259918903583 0.413239332331297 no 1361 0.431616596677102 1946 16192618
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.171118484397677 0.413647115103723 no 1362 0.432065300894454 2038 97141
SGTC_3093 9117344 49.47 µM 0.17102521333944 0.413680440744555 no 1363 0.432101970144717 2029 24824913
SGTC_926 2268-1401 59.4 µM 0.170464569653224 0.413880771175436 no 1364 0.432322397923725 2120 2931578
SGTC_2419 paclitaxel 166.5 µM 0.168971735664515 0.414414303050851 no 1365 0.432909436684248 1964 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3135 9127742 49.47 µM 0.168659017186534 0.414526087212798 no 1366 0.433032428215528 1954 3643468
SGTC_1887 st057648 70.8 µM 0.168609780302993 0.414543688031063 no 1367 0.433051793571492 2120 688672
SGTC_2388 9080168 200 µM 0.168584580336102 0.414552696385657 no 1368 0.433061705031287 1922 15943073
SGTC_1534 6-azauridine 81.6 µM 0.167795115421873 0.414834932978457 no 1369 0.433372232673208 2050 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2907 7721985 69.9 µM 0.165950002191143 0.415494738918051 no 1370 0.4340981484729 1959 3267881
SGTC_1688 st021091 57.6 µM 0.165113676174758 0.415793884745552 no 1371 0.434427254362667 2141 3656366
SGTC_167 3672-0051 66.205 µM 0.164994253936285 0.415836604925373 no 1372 0.43447425238374 2047 3237971
SGTC_2483 5729050 27.16 µM 0.164541085729133 0.415998723033241 no 1373 0.434652602870446 2114 2865180
SGTC_1971 st069429 63.5 µM 0.164526396849727 0.416003978127831 no 1374 0.434658384100634 2121 1246522 YGL099W LSG1
SGTC_1402 3909-7673 35.9 µM 0.159839909867411 0.417681377897264 no 1375 0.436503592354082 2092 5328014
SGTC_1796 st049173 110.4 µM 0.159134686674626 0.417933923735024 no 1376 0.436781380202083 2120 94134
SGTC_785 1270-0111 65.3 µM 0.159104785140537 0.417944632452532 no 1377 0.436793159124613 2176 6741994
SGTC_2772 vinpocetine 57.06 µM 0.157085681784013 0.418667879773827 no 1378 0.437588660883399 2103 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_472 calcifediol 10 µM 0.156604915573699 0.418840131930214 no 1379 0.437778114141736 2037 5283731 A vitamin D metabolite.
SGTC_1871 st057448 67.3 µM 0.155714414909075 0.419159227587504 no 1380 0.438129067159897 2097 691747
SGTC_2201 6605497 169.863 µM 0.154384243230896 0.419635970809818 no 1381 0.438653388395666 2100 670741
SGTC_2351 9026858 72.31 µM 0.151751722065796 0.420579832729796 no 1382 0.439691380612067 2050 1409300
SGTC_2851 9015922 71.43 µM 0.151496046773157 0.420671526757343 no 1383 0.4397922145328 2100 2996893
SGTC_1142 3253-1408 9.78 µM 0.149650756746071 0.421333439102232 no 1384 0.440520080480777 2157 256655
SGTC_186 3455-3465 67.277 µM 0.148153714383457 0.421870597204012 no 1385 0.441110729591596 2097 755278
SGTC_2041 5107442 45.335 µM 0.146694913377249 0.422394173696093 no 1386 0.441686416853162 2130 793005
SGTC_1089 terbinafine 2.25 µM 0.146488030729152 0.42246843682154 no 1387 0.441768069043934 2128 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1686 st019653 115.5 µM 0.146354416324113 0.422516400855686 no 1388 0.441820805129465 2148 97252
SGTC_1128 3448-9350 235 µM 0.14607394068277 0.422617087922023 no 1389 0.441931509027495 1980 619386
SGTC_15 0266-0086 27.098 µM 0.145481568255637 0.422829758440718 no 1390 0.442165333662795 2154 1712902 YIL048W NEO1
SGTC_980 1473-0395 201 µM 0.144650141273578 0.4231282910301 no 1391 0.442493553253273 2018 768876
SGTC_3256 9138902 49.47 µM 0.143277665162953 0.423621189492736 no 1392 0.44303544722312 2158 17228773
SGTC_324 1315-0088 19.6 µM 0.141225725008169 0.424358327156626 no 1393 0.443845812061541 2110 6787421
SGTC_2922 7999257 32.47 µM 0.140232148609408 0.424715354169717 no 1394 0.444238285972958 2143 2988377
SGTC_1689 st020265 53.493 µM 0.139813333167966 0.424865867840206 no 1395 0.444403739214202 2151 5758320 YPR016C TIF6
SGTC_614 0462-0418 107 µM 0.139042449926703 0.425142936071221 no 1396 0.44470830231647 2131 5188303
SGTC_2143 5623677 140.463 µM 0.134632715193927 0.426728574666869 no 1397 0.446451137052244 2146 5375313
SGTC_2261 9010538 184.68 µM 0.134301800592258 0.426847612013038 no 1398 0.446581964738034 2008 6457250
SGTC_3057 9095946 49.47 µM 0.134231415416661 0.426872931986629 no 1399 0.446609792394766 2179 24540043
SGTC_1625 st003711 30.1 µM 0.133747238634806 0.427047115223041 no 1400 0.446801224839835 2132 24207034 YER133W GLC7
SGTC_676 falcarinol 140 µM 0.133381879041368 0.427178563238055 no 1401 0.446945687890736 2170 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_387 norethindrone acetate 66.7 µM 0.133359724350161 0.427186534248774 no 1402 0.4469544480742 2049 541197
SGTC_743 1275-0778 158 µM 0.131698002208836 0.427784487849365 no 1403 0.447611582880511 2155 2849257 YMR203W TOM40
SGTC_2756 carbadox 75.1 µM 0.130224807307485 0.428314740643534 no 1404 0.448194284152331 2053 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1163 k060-0048 49.9 µM 0.13008077628853 0.428366589252888 no 1405 0.448251259591154 2166 6809982
SGTC_2543 pimpinellin 60.67 µM 0.12982115768107 0.428460050464366 no 1406 0.448353961581487 2029 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.129107985229076 0.428716809096784 no 1407 0.448636101797607 2092 521171
SGTC_81 0411-0046 9.971 µM 0.12680604302749 0.429545767035351 no 1408 0.449546956354115 2120 12925265
SGTC_3248 9135562 49.47 µM 0.126133082190162 0.429788167444877 no 1409 0.449813290393967 2062 17650701
SGTC_796 1234-0020 70.7 µM 0.125594153032641 0.429982308751763 no 1410 0.450026595754986 2192 46495034
SGTC_427 1354-0053 47.3 µM 0.12534036317699 0.430073738683079 no 1411 0.450127049465787 2141 6813657
SGTC_2677 mitomycin C 100 µM 0.122026613134576 0.431267887370404 no 1412 0.451438970767215 2147 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2917 7979103 53.79 µM 0.121125441828048 0.431592744182523 no 1413 0.45179583893551 2150 2980565
SGTC_2786 7743617 45.45 µM 0.121070571750552 0.431612525401773 no 1414 0.451817569010961 2049 583674
SGTC_2857 9024691 58.44 µM 0.120411137506301 0.431850271534216 no 1415 0.452078734570428 2100 16478292
SGTC_2322 7413319 38.22 µM 0.120242954482047 0.431910910591709 no 1416 0.452145345920407 2100 1840400
SGTC_907 3448-6986 75.5 µM 0.119516530852006 0.432172843928927 no 1417 0.452433072089441 2179 590582
SGTC_3185 9108267 49.47 µM 0.119377672274464 0.432222916858149 no 1418 0.452488074864986 2064 4910486
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.117065020926917 0.433057027151251 no 1419 0.45340426417945 2100 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2381 9035592 200 µM 0.115899981450825 0.433477338361432 no 1420 0.453865905198935 2023 4749657
SGTC_3050 9093513 49.47 µM 0.115661375847567 0.433563429387093 no 1421 0.45396045917767 2164 25236664
SGTC_1324 1418-0026 34.4 µM 0.115180762617051 0.433736848484252 no 1422 0.45415092319623 2121 1372513
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.11412576884459 0.434117565314337 no 1423 0.454569047547086 2223 16725076
SGTC_3109 9122853 49.47 µM 0.113845863165076 0.434218585476135 no 1424 0.454679990681558 2149 1234709
SGTC_2120 5538279 151.968 µM 0.113328365761065 0.43440536566899 no 1425 0.454885114737741 2129 2058197
SGTC_2751 anetholtrithion 17.25 µM 0.11095484677423 0.435262226185266 no 1426 0.45582607631088 2166 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2553 4-methylesculetin 85.09 µM 0.1101032206119 0.435569744798263 no 1427 0.456163757005068 2131 5319502
SGTC_3356 9151811 4.48 µM 0.109552241077295 0.435768721954214 no 1428 0.456382244341332 2136 1859254 YPR165W RHO1
SGTC_338 4055-0136 114 µM 0.109237970257304 0.435882222954329 no 1429 0.456506872293497 2192 2900563
SGTC_2624 nerol 100 µM 0.107832467617371 0.436389894087651 no 1430 0.457064293805185 2174 637566 A natural product oil.
SGTC_3027 9089541 49.47 µM 0.107781686667515 0.436408238262731 no 1431 0.457084435087698 2129 9943819
SGTC_2240 6690706 185.951 µM 0.107553826799887 0.436490552335065 no 1432 0.457174812657601 2060 805876
SGTC_16 erodoxin 22.806 µM 0.107396849844932 0.436547261650257 no 1433 0.457237076756775 2188 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3044 9093193 49.47 µM 0.106571136266848 0.436845579438445 no 1434 0.457564609034104 2084 25236277
SGTC_66 0109-0187 42.4 µM 0.106569956770878 0.436846005598174 no 1435 0.457565076920399 2246 759417
SGTC_2836 9010338 19.48 µM 0.10650466912721 0.436869594571785 no 1436 0.457590975526827 2051 2994051
SGTC_149 3970-0822 46.1 µM 0.10644598082239 0.436890799340464 no 1437 0.457614256430502 2202 3114250 YBL034C STU1
SGTC_2091 4-phenylthiadiazole 200 µM 0.105372160233401 0.437278815186241 no 1438 0.458040252988081 2147 270010
SGTC_114 0364-0001 490.298 µM 0.105001311396966 0.437412832263021 no 1439 0.458187384064685 2063 4003655
SGTC_1397 3532-0190 20.1 µM 0.1045046699196 0.437592319436155 no 1440 0.458384431256887 2136 5322280
SGTC_2204 7233102 200 µM 0.104287174252488 0.437670926829099 no 1441 0.458470727937981 2171 2172480
SGTC_2587 piperic acid 92.2 µM 0.104261781303418 0.437680104521899 no 1442 0.458480803334092 2126 5370536
SGTC_2626 ethyl orsellinate 100 µM 0.103409729132866 0.437988078433547 no 1443 0.458818895406796 2165 75653 A natural product.
SGTC_224 benfluorex 43.875 µM 0.103095296453683 0.438101739496934 no 1444 0.458943669009728 2221 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2455 5377712 9.75 µM 0.103058034595487 0.438115209244759 no 1445 0.458958455579224 2049 2243908
SGTC_1375 2910-0797 186 µM 0.103008458217356 0.438133130665901 no 1446 0.458978128989949 2146 742508
SGTC_1935 st074532 41.6 µM 0.10298221292032 0.438142618159451 no 1447 0.45898854396063 2193 2829742
SGTC_892 0929-0076 29 µM 0.10240365992737 0.438351770090128 no 1448 0.459218139372225 2128 5751038
SGTC_3237 9133362 49.47 µM 0.101033261034253 0.438847249785149 no 1449 0.459762028385352 2230 43845137
SGTC_667 1498-1044 59 µM 0.101026911252873 0.438849545827773 no 1450 0.459764548686284 2150 6739982
SGTC_312 4092-0653 6.84 µM 0.0998687400406799 0.439268367887558 no 1451 0.460224267040015 2201 1148278
SGTC_1859 st055998 20 µM 0.0961441378747131 0.440615730623637 no 1452 0.461703048348465 2244 676301
SGTC_2218 6965428 192.983 µM 0.0951349153957256 0.440980932664794 no 1453 0.462103832679909 2211 675684
SGTC_2160 5660466 132.927 µM 0.0948701371419433 0.441076754906574 no 1454 0.46220898830761 2245 2859134
SGTC_1265 0819-1001 68.8 µM 0.0946411102181228 0.4411596416608 no 1455 0.462299947568017 2245 3106768
SGTC_1347 1493-0251 600 nM 0.0935498976621246 0.441554595920678 no 1456 0.462733355430053 2243 3986378
SGTC_546 peri-Naphthalide 147 µM 0.0931337916941622 0.441705216943503 no 1457 0.462898636101553 2197 223824 A penicillin ester.
SGTC_903 1134-0042 114 µM 0.0926180037292107 0.44189193231112 no 1458 0.463103520159881 2114 701009
SGTC_213 1246-0773 967 nM 0.0912302982494105 0.442394346016139 no 1459 0.463654800404442 2173 6251622
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.0904789663818132 0.442666401695818 no 1460 0.46395330389202 2133 6857784
SGTC_1480 1070-0044 41.2 µM 0.0897275001228108 0.442938533083126 no 1461 0.464251881071496 2228 3124987
SGTC_1862 st057513 3.81 µM 0.0887168313633011 0.443304572903671 no 1462 0.464653477893894 2227 5393163
SGTC_95 0471-0001 561.058 µM 0.0870230277649924 0.443918136010631 no 1463 0.465326604015922 2084 4015405
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.08653591347311 0.444094613160432 no 1464 0.465520204156285 2212 688669
SGTC_442 cape 100 µM 0.0862319261612339 0.444204750663638 no 1465 0.465641025908278 2251 5281787
SGTC_831 k061-1017 217 µM 0.0849229694552463 0.444679047283172 no 1466 0.466161315382246 2229 1240153
SGTC_2225 6654152 15.4 µM 0.0840965566874203 0.444978536363281 no 1467 0.466489831156606 2238 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3278 9139605 49.47 µM 0.0840273662179609 0.445003612173316 no 1468 0.466517336805241 2211 7958859
SGTC_2361 9034121 116 µM 0.0837586504350572 0.445101001457111 no 1469 0.466624162309004 2158 6496917
SGTC_1712 st032288 53.4 µM 0.0829274072789107 0.445402285606745 no 1470 0.466954630618023 2240 2883011
SGTC_57 miconazole 162.5 nM 0.081962424954794 0.445752083072162 no 1471 0.467338296713143 2259 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_501 nsc-95397 161 µM 0.0804101487830665 0.446314857798119 no 1472 0.467955527740934 2226 262093
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0784356606962564 0.447030860778149 no 1473 0.46874075388167 2214 688664
SGTC_3252 9135871 49.47 µM 0.0770741479893251 0.447524682980169 no 1474 0.469282279363156 2243 17682838
SGTC_2822 7994718 71.43 µM 0.0755715620870545 0.448069766995932 no 1475 0.46987998095663 2273 1018011
SGTC_1326 1431-2094 10.8 µM 0.0746604569903437 0.44840033091765 no 1476 0.47024243528646 2264 616278
SGTC_2198 6589944 200 µM 0.0742010445869924 0.448567026900237 no 1477 0.470425207342061 2230 5290268
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0736168533766646 0.448779011493685 no 1478 0.470657630235865 2269 6708784 An antioxidant flavonoid
SGTC_2264 7948757 110.76 µM 0.0734239645629227 0.448849007984279 no 1479 0.470734374048669 2270 2971411
SGTC_2701 st077767 14.721 µM 0.0730345451363384 0.448990327369986 no 1480 0.470889313929926 2221 5721188
SGTC_975 1335-0046 28.5 µM 0.0724630801683229 0.449197722362443 no 1481 0.471116692978282 2203 16486740
SGTC_1675 st018485 24.5 µM 0.0721643200071036 0.44930615336762 no 1482 0.471235569811555 2143 3323024
SGTC_1655 st012546 55.1 µM 0.0721555672593156 0.449309330117498 no 1483 0.471239052573433 2240 720985 YLR208W SEC13
SGTC_2862 9027634 71.43 µM 0.0701745121638073 0.450028423702012 no 1484 0.472027380324348 2254 5012562
SGTC_864 0469-0573 172 µM 0.0675591479709294 0.450978013031642 no 1485 0.473068288129023 2139 689425
SGTC_2719 novobiocin 32.65 µM 0.0673769190592673 0.451044187427583 no 1486 0.473140821674479 2268 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_931 2812-0076 566 µM 0.0673759321707511 0.451044545808842 no 1487 0.473141214493405 2294 3450959
SGTC_3345 9148410 3.559 µM 0.0672318830880064 0.451096856594753 no 1488 0.473198551752124 2261 4903596
SGTC_563 tetrahydrosecaminediol 614 µM 0.0667081655115066 0.451287049461944 no 1489 0.473407016828167 2283 334274 A psychoactive constituent of the cannabis plant.
SGTC_946 3434-1334 87.4 µM 0.0640041911219987 0.452269199669392 no 1490 0.474483444809936 2263 4047976
SGTC_2318 6029776 164 µM 0.0629150787190124 0.452664875037022 no 1491 0.474917063775633 2264 818325
SGTC_1196 1588-0294 184 µM 0.0600653609513503 0.453700401109075 no 1492 0.476051789043196 2209 6144269
SGTC_2790 5423970 71.43 µM 0.059449919544106 0.453924080846503 no 1493 0.476296876645975 2280 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2054 5233173 129 µM 0.059027561845613 0.454077593537152 no 1494 0.476465077601256 2262 6889
SGTC_523 1934-0222 13.7 µM 0.0587047570250227 0.454194926761794 no 1495 0.476593635158463 2296 1361595
SGTC_2187 6125751 200 µM 0.0586459719443441 0.454216294416875 no 1496 0.476617046677323 2250 874498
SGTC_3119 9125183 49.47 µM 0.0573743846615698 0.454678533112154 no 1497 0.477123483730168 2301 22695334
SGTC_1109 tnp00067 928.257 nM 0.0573347163999381 0.454692954037279 no 1498 0.477139283069226 2189 676295
SGTC_302 1094-0063 18.9 µM 0.0571066196168411 0.45477587707053 no 1499 0.477230131669558 2278 5440289
SGTC_349 k015-0014 24 µM 0.0567745680314655 0.454896595686534 no 1500 0.477362386511365 2279 2196908
SGTC_1288 0973-0013 65.5 µM 0.0556803123051529 0.45529444593744 no 1501 0.477798241835846 2251 4315430
SGTC_1399 3562-5772 25 µM 0.0555662499314841 0.455335919401337 no 1502 0.477843675799696 2303 23847490
SGTC_1746 st038117 42 µM 0.0545716884391841 0.455697565893225 no 1503 0.478239847244419 2245 2898218
SGTC_3173 9105693 49.47 µM 0.054327205035552 0.455786471574957 no 1504 0.47833723753513 2279 17096658
SGTC_3049 9092223 49.47 µM 0.0540003702070182 0.455905327571318 no 1505 0.478467434645557 2244 8623917
SGTC_1961 st076550 68.7 µM 0.0537066835704394 0.456012132339419 no 1506 0.478584428885105 2268 1579337
SGTC_910 3454-3003 490 µM 0.0530905163637959 0.456236223661982 no 1507 0.47882989382152 2312 820824
SGTC_1117 retinoic acid 1.10837 µM 0.0508968992372992 0.457034123781338 no 1508 0.479703838179749 2300 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_750 4073-0104 132 µM 0.049914571084505 0.457391489411391 no 1509 0.48009523286575 2316 22330957
SGTC_2190 6049624 200 µM 0.0496757266389266 0.457478384937589 no 1510 0.480190399954033 2293 2265554
SGTC_428 3448-4153 16.5 µM 0.0494996706916987 0.457542438280085 no 1511 0.480260549814823 2295 3834874
SGTC_2113 5491891 107.031 µM 0.0488409337876991 0.45778211220878 no 1512 0.480523030318883 2287 789979
SGTC_2963 9082507 9 µM 0.0463563647794078 0.458686231818865 no 1513 0.481513107480027 2294 16459611
SGTC_181 1447-1644 8.07 µM 0.0461114987336986 0.458775348737159 no 1514 0.481610690547064 2322 534600
SGTC_656 4090-1979 187 µM 0.045982377272787 0.458822342231161 no 1515 0.481662147975046 2331 22330961
SGTC_1980 st071811 45.7 µM 0.0439281212005055 0.459570061535122 no 1516 0.482480849727464 2291 4974850
SGTC_3235 9132602 49.47 µM 0.0438775276963183 0.459588478649564 no 1517 0.482501014172968 2262 4912240
SGTC_1181 1222-0449 220 µM 0.0435693937182968 0.459700647859542 no 1518 0.482623824397549 2301 658318
SGTC_1035 k081-0041 55.2 µM 0.0433211280624832 0.459791025693871 no 1519 0.482722774636264 2317 731709
SGTC_1725 st036284 20.55 µM 0.0427620945061057 0.459994542079177 no 1520 0.482945590267624 2318 707914
SGTC_1899 st063254 59.6 µM 0.042267749118502 0.460174517445727 no 1521 0.483142627387237 2318 3093813
SGTC_2586 curcumin 80 µM 0.0408364548215944 0.46069565186854 no 1522 0.483713138420996 2315 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1174 0739-0097 51.1 µM 0.0393879389534942 0.461223125401456 no 1523 0.484290547884725 2289 728447
SGTC_135 0933-0004 26.348 µM 0.0392587893235017 0.461270158251655 no 1524 0.484342031312093 2299 21230617 YGL099W LSG1
SGTC_572 0960-0087 17.7 µM 0.0372509509365856 0.462001428701919 no 1525 0.485142456902716 2321 6796365
SGTC_893 0958-0369 48.9 µM 0.0366292513650226 0.462227882713581 no 1526 0.485390309979259 2348 6819948
SGTC_988 1497-1057 103 µM 0.0351933560247535 0.462750954135418 no 1527 0.485962780037624 2337 3533044
SGTC_2252 omeprazole 400 µM 0.0335467396735556 0.463350866752666 no 1528 0.48661929695927 2309 4594 A proton pump inhibitor.
SGTC_2567 aureobasidin a 60 nM 0.0327571269659392 0.46363857642663 no 1529 0.486934133786945 2275 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1072 oxiconazole 14.9 nM 0.0324547200067951 0.46374876891739 no 1530 0.487054712594883 2345 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1189 1431-2119 7.28 µM 0.0323496457587875 0.463787057024722 no 1531 0.487096609155572 2350 3107275
SGTC_2697 mebhydrolin 72.4 µM 0.0319875387180033 0.46391900812858 no 1532 0.487240994237888 2335 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1115 galangin 695.678 nM 0.0314511419578856 0.464114477358252 no 1533 0.487454877958963 2359 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1777 st045864 34.765 µM 0.0311689937800329 0.464217298921421 no 1534 0.487567383636753 2355 4691462
SGTC_974 1326-0144 138 µM 0.0301160808201178 0.46460102670228 no 1535 0.487987237954109 2316 5411856
SGTC_1597 7-benzyloxygramine 47.5 µM 0.0292606837068404 0.464912795280372 no 1536 0.488328341661194 2361 260807
SGTC_1666 st014829 29 µM 0.0291423432002636 0.46495592882093 no 1537 0.488375532567921 2342 3858230
SGTC_2445 5742597 35.57 µM 0.0287536393198293 0.465097609109943 no 1538 0.488530538019585 2317 1774255
SGTC_999 SEC7.066 22.7 µM 0.0278292650664486 0.465434555854153 no 1539 0.488899162424888 2337 740511 YDR170C SEC7
SGTC_1244 0416-0015 52.5 µM 0.0264800374275191 0.465926411744365 no 1540 0.489437227920527 2340 96201
SGTC_17 0960-0276 49.807 µM 0.022235521054185 0.467474070269689 no 1541 0.491130041442533 2365 6821114
SGTC_526 4469-0568 170 µM 0.0214762610487673 0.467750968293012 no 1542 0.491432870017029 2367 2901964
SGTC_2939 9044578 71.43 µM 0.0187172238220348 0.468757304664141 no 1543 0.492533344019357 2364 2653634
SGTC_504 lovastatin 124 µM 0.017850919100075 0.469073323748796 no 1544 0.492878891825455 2361 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2832 7992762 51.95 µM 0.0178431152325024 0.469076170608565 no 1545 0.492882004622403 2368 2985177
SGTC_2644 guaiazulene 100 µM 0.0176328088293896 0.469152891218642 no 1546 0.492965891540359 2365 3515 A coloring agent.
SGTC_354 2783-3500 4.88 µM 0.0168567730994398 0.469436002020578 no 1547 0.493275438965907 2366 6740761
SGTC_1822 st052468 42 µM 0.0159314007869961 0.469773613491719 no 1548 0.493644559486413 2370 2873678
SGTC_1773 st048542 73.5835 µM 0.0158484969885986 0.469803861055648 no 1549 0.49367762914164 2357 3237138
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0151827909605991 0.470046751110594 no 1550 0.493943175452528 2375 23665772 A membrane-active detergent.
SGTC_22 0964-0034 14.468 µM 0.015178129645393 0.470048451881335 no 1551 0.493945034833989 2371 138402
SGTC_3186 9110464 49.47 µM 0.0143532258162778 0.470349442526813 no 1552 0.494274087966461 2377 17018021
SGTC_2221 6807166 181.081 µM 0.0125850884464796 0.470994656778515 no 1553 0.494979408647059 2387 674925
SGTC_2057 5236571 38.335 µM 0.0123350478266594 0.471085905744358 no 1554 0.495079152678767 2372 54684039 YBR257W POP4
SGTC_878 0828-0289 13.7 µM 0.0121551494040506 0.471151558196689 no 1555 0.495150916385212 2381 745350 YLR208W SEC13
SGTC_109 0132-0036 33.701 µM 0.0116300564644411 0.471343191031336 no 1556 0.495360383344157 2375 67274 A color developer.
SGTC_1850 st056238 17 µM 0.011266503654011 0.471475873634665 no 1557 0.495505410426436 2382 5393177
SGTC_250 brefeldin a 552.239 µM 0.0112233334523476 0.471491629285939 no 1558 0.495522631756294 2375 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1965 Pectolinarigenin 58.4 µM 0.00901227341734493 0.472298649903055 no 1559 0.496404671760751 2387 5320438 An anti-inflammatory.
SGTC_357 1325-0123 420 µM 0.00877779750899908 0.472384238609605 no 1560 0.496498210413572 2394 1098503
SGTC_1519 esterone 74 µM 0.00793615177446161 0.4726914677255 no 1561 0.496833966747637 2381 698 A steroid.
SGTC_1374 2889-5571 141 µM 0.00744867848622423 0.472869419379981 no 1562 0.49702843469722 2384 2853281
SGTC_1650 st011916 45.8 µM 0.00472906869103774 0.473862308701248 no 1563 0.498113381584309 2394 242528
SGTC_2174 5790901 200 µM 0.0046023950020119 0.473908559397727 no 1564 0.49816391652459 2396 786020
SGTC_1820 st053765 18.6 µM 0.00401236371126489 0.47412399437962 no 1565 0.498399302766183 2390 3690829
SGTC_234 nsc-17383 10.7 µM 0.00231874958853736 0.47474241649886 no 1566 0.499074953580403 2399 408974
SGTC_3269 9137823 49.47 µM 0.00226643294179675 0.474761520865841 no 1567 0.499095824847905 2403 17682936
SGTC_1882 5615643 20 µM 0.00135956646582902 0.475092688696682 no 1568 0.499457611620859 2402 2253075
SGTC_943 3253-1379 105 µM 0.00113593428199451 0.475174356939954 no 1569 0.499546827884613 2404 668464
SGTC_3216 9129716 49.47 µM -3.23913867186724e-05 0.475601034703435 no 1570 0.499987077706319 2406 8056934
SGTC_866 0495-0101 262 µM -0.00267147213644147 0.476564941039805 no 1571 0.498934238081541 2413 635694
SGTC_1327 1436-0082 2.18 µM -0.00435144234550567 0.477178610552923 no 1572 0.498264031146093 2419 15992205
SGTC_1764 st044502 93.5 µM -0.00540365717277601 0.477562997502496 no 1573 0.497844263176067 2420 8407
SGTC_3031 9088762 49.47 µM -0.00705805336166371 0.478167410746343 no 1574 0.497184267474866 2419 205253
SGTC_920 mycophenolic acid 780.421 nM -0.00709292844384388 0.478180152472833 no 1575 0.497170354678312 2419 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1425 4048-4433 7.33 µM -0.00781134374762138 0.478442632820306 no 1576 0.496883756403043 2418 23734946
SGTC_3200 9114385 49.47 µM -0.0096317119648658 0.479107764490125 no 1577 0.49615756227507 2438 17018030 YLR208W SEC13
SGTC_454 lyso-paf C-16 6.67 µM -0.0100581431012285 0.479263583674116 no 1578 0.495987449110489 2437 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_804 1595-0054 20.9 µM -0.0107970530555729 0.479533591021549 no 1579 0.495692682721115 2424 761523 Stimulates phospholipase C.
SGTC_1299 1079-1439 3.74 µM -0.0114885250082751 0.479786272412799 no 1580 0.495416842453902 2436 323161
SGTC_2473 5854593 8.94 µM -0.0117364586948849 0.479876875654718 no 1581 0.495317937892694 2426 2872951
SGTC_2308 7584454 197.62 µM -0.0119182642891882 0.479943314146187 no 1582 0.495245413027214 2431 893577
SGTC_1335 1486-0900 202 µM -0.0119957284676526 0.479971622592781 no 1583 0.495214511500287 2431 X1335
SGTC_2605 digitonin 300 nM -0.0123937189302401 0.480117065494481 no 1584 0.495055748084006 2432 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1002 4049-0206 172 µM -0.0131869940055791 0.480406970340829 no 1585 0.494739303009954 2440 4662749
SGTC_648 0375-0473 33.3 µM -0.0131877208904083 0.480407235987929 no 1586 0.494739013050077 2427 1713139
SGTC_113 0099-0221 2.5 µM -0.0136573006415158 0.480578850268596 no 1587 0.494551694709812 2430 89219
SGTC_3344 9148862 3.898 µM -0.013947322431015 0.480684844460186 no 1588 0.494436003776455 2444 4905352
SGTC_1993 st073995 70.8 µM -0.0146810767048656 0.480953015533965 no 1589 0.494143308167417 2457 3098394
SGTC_550 4123-0385 25.7 µM -0.0150597166488853 0.481091403497954 no 1590 0.493992269386029 2452 5731123
SGTC_1073 triclabendazole 3.09 µM -0.0152616229656512 0.481165198557486 no 1591 0.493911729676121 2443 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1787 fluconazole 80 µM -0.0153779346498788 0.48120770979235 no 1592 0.493865333472417 2447 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1195 1502-0147 41.1 µM -0.0161344787084884 0.481484227379604 no 1593 0.493563553529622 2427 817940
SGTC_1017 4239-0030 168 µM -0.0179656541562873 0.482153560398445 no 1594 0.492833126499725 2456 1149593
SGTC_2027 5150920 200 µM -0.018019294780774 0.482173167938928 no 1595 0.492811730450216 2457 786715
SGTC_2954 9074818 52.69 µM -0.0197463433924493 0.48280448791069 no 1596 0.492122860647258 2461 16648742
SGTC_772 k072-0172 35.3 µM -0.0219141967583335 0.483597004224846 no 1597 0.491258200059704 2450 5861980
SGTC_3006 9075424 71.4286 µM -0.022055169619488 0.483648542872515 no 1598 0.491201973614549 2456 7465181
SGTC_196 k015-0023 18.111 µM -0.0223663014128416 0.483762291347765 no 1599 0.491077880600261 2443 5211998
SGTC_2666 tannic acid 100 µM -0.0225516390284596 0.483830050629313 no 1600 0.491003960234613 2452 16134267 A thiamine antagonist.
SGTC_2339 9000433 200 µM -0.0226395557940033 0.483862193090719 no 1601 0.490968895472186 2470 2988954
SGTC_972 1319-0219 195 µM -0.0230033533586064 0.483995198973224 no 1602 0.490823799032355 2462 23903702
SGTC_2480 5767542 37.17 µM -0.0232892989959832 0.484099743122428 no 1603 0.490709753782198 2475 2867358
SGTC_1545 lovastatin 49.4 µM -0.0239904546205909 0.48435609617454 no 1604 0.490430111313272 2450 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2889 9059656 51.95 µM -0.0249917227407826 0.484722186057295 no 1605 0.490030782922011 2478 3949838
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0253430432714067 0.48485064112447 no 1606 0.489890670689465 2475 115019
SGTC_1357 1503-1303 39.5 µM -0.0262659337933639 0.485188089616075 no 1607 0.489522613213049 2454 292895
SGTC_488 nitrendipine 139 µM -0.0264023079594276 0.485237954785443 no 1608 0.48946822665372 2437 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2804 7954240 19.48 µM -0.0266490473334855 0.485328175543272 no 1609 0.489369826509249 2472 828705
SGTC_2934 9036370 36.88 µM -0.0270944065358692 0.485491023946546 no 1610 0.489192218031124 2487 6462800
SGTC_288 1315-0019 35.1 µM -0.0274429538781952 0.485618474171451 no 1611 0.489053219448207 2480 6811474
SGTC_2471 5466956 24.79 µM -0.0278093502911524 0.485752452691818 no 1612 0.48890710419704 2513 724419
SGTC_1260 0700-1617 7.75 µM -0.0279599096583113 0.485807507522225 no 1613 0.48884706304694 2473 2853078
SGTC_2278 7948257 134.34 µM -0.0297672987674598 0.486468433751699 no 1614 0.488126319503243 2460 1247028
SGTC_1680 diphenhydramine 100 µM -0.030306106369732 0.486665472243611 no 1615 0.487911463316159 2522 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1785 bathophenanthroline 24 µM -0.0305030220800193 0.486737483873433 no 1616 0.487832941616369 2465 72812 An iron chelator.
SGTC_2853 9015042 58.44 µM -0.030819918199063 0.486853372974292 no 1617 0.487706577769432 2470 6457456
SGTC_3333 9141820 12.094 µM -0.031911927757404 0.487252729968236 no 1618 0.487271143255159 2488 1939433
SGTC_256 clotrimazole 625 nM -0.032027746473966 0.487295086594636 no 1619 0.487224961878629 2447 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_887 0885-0007 9.62 µM -0.0332799977838994 0.487753062566532 no 1620 0.486725652189799 2567 5719458
SGTC_2282 7944268 200 µM -0.0339754738383915 0.488007420540034 no 1621 0.486448354224257 2494 2970414
SGTC_1709 st033179 39.1045 µM -0.0363579465041308 0.488878803806313 no 1622 0.485498472910066 2455 573381
SGTC_1243 0416-0003 5.65 µM -0.0384771307402201 0.489653934746028 no 1623 0.484653632502146 2507 2141977
SGTC_1133 3473-0247 50 µM -0.0385648839517834 0.489686032973487 no 1624 0.484618650000162 2544 711311
SGTC_918 glabranin 770.725 nM -0.0385988957208435 0.489698473761207 no 1625 0.484605091362648 2499 124049 Also referred to as licorice root.
SGTC_1703 st026983 48.3 µM -0.0393073149228926 0.489957600823012 no 1626 0.484322687329988 2487 1104023
SGTC_2299 7976368 114.88 µM -0.039894423033668 0.490172357676189 no 1627 0.484088648669845 2499 2979718
SGTC_1355 1499-0035 1.68 µM -0.0402646551791402 0.490307785464288 no 1628 0.483941065998058 2479 1548538
SGTC_3082 9117008 49.47 µM -0.0406950242615812 0.490465212238684 no 1629 0.483769514187705 2511 41448529
SGTC_340 k038-0059 454 µM -0.0407900333975944 0.490499966288024 no 1630 0.483731642472033 2474 23733424
SGTC_3309 9129340 25.759 µM -0.0407909514297096 0.490500302101697 no 1631 0.483731276534769 2521 17158987
SGTC_2683 piperine 63.03 µM -0.0410885390788913 0.49060915921495 no 1632 0.483612655689477 2480 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_300 r073-0011 5.04 µM -0.0413650875283531 0.490710320847876 no 1633 0.483502422539469 2481 2735780
SGTC_107 0358-0022 2.6945 µM -0.041387883549807 0.49071865967659 no 1634 0.483493336024135 2560 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1381 2324-0066 62.1 µM -0.0415107709922895 0.490763612210386 no 1635 0.483444353123164 2525 10885928
SGTC_1021 4476-0760 85.3 µM -0.0420422402277574 0.490958026329427 no 1636 0.483232512517782 2486 746768
SGTC_2618 avocadyne 43.43 µM -0.0421092311569012 0.490982532101599 no 1637 0.483205810650273 2495 3015189
SGTC_136 0097-0015 404.482 µM -0.0423627241632024 0.491075262005865 no 1638 0.483104771733287 2468 4861337
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0433994472257737 0.491454509113029 no 1639 0.482691559168794 2466 368090
SGTC_2736 butenafine 14.65 µM -0.0441171204368208 0.491717048079653 no 1640 0.482405522967918 2518 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2024 5144227 134 µM -0.0449580231785794 0.49202467138778 no 1641 0.482070383875441 2510 3475211
SGTC_2737 bleomycin 30.5 nM -0.0459678249474044 0.492394088447052 no 1642 0.481667947380549 2491 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2598 perillyl alcohol 100 µM -0.0461607548530236 0.492464668990589 no 1643 0.481591061100672 2536 10819 An apoptosis inducer.
SGTC_2981 9013952 38.96 µM -0.0467780571004132 0.492690501433236 no 1644 0.48134505889103 2527 2996344
SGTC_1840 st055363 71 µM -0.0472835129249549 0.492875417984112 no 1645 0.481143634082353 2539 676033
SGTC_3011 9081274 71.4286 µM -0.0473036064671372 0.492882769061024 no 1646 0.481135626878603 2514 6625322
SGTC_2974 9094440 9.66 µM -0.0480178213750892 0.493144060964673 no 1647 0.480851019792917 2685 25236134
SGTC_751 0833-0568 350 µM -0.0484827412546778 0.49331415113358 no 1648 0.48066575937461 2533 6954252
SGTC_2894 9048625 32.47 µM -0.0497655459982936 0.49378346933722 no 1649 0.480154611478437 2505 4092861
SGTC_3352 9151559 45.5865 µM -0.0503216514288303 0.49398692499302 no 1650 0.479933035140126 2519 17159339
SGTC_1123 mangostin 811.285 nM -0.0507940043547103 0.494159740350312 no 1651 0.47974483427179 2557 5281650 An antioxidant.
SGTC_2482 5981709 142.65 µM -0.0514147535928168 0.494386849743144 no 1652 0.479497514327603 2555 877755
SGTC_1436 4092-1007 8.32 µM -0.0517116633143504 0.494495478774857 no 1653 0.47937922184715 2503 2881121
SGTC_1552 6-methylflavone 10.6 µM -0.0526265536580307 0.494830208144038 no 1654 0.47901472976118 2515 689013
SGTC_856 0433-0016 11.3 µM -0.0542985029129209 0.495441930601664 no 1655 0.478348671149013 2554 3911780
SGTC_902 1120-0002 2.07 µM -0.0543406590407395 0.495457354569675 no 1656 0.478331878080489 2522 3280475
SGTC_400 oxethazaine 37.5 µM -0.0559015455407755 0.496028452011664 no 1657 0.477710119796834 2554 4621 A local anesthetic.
SGTC_1467 k284-1082 293 µM -0.0559703528551082 0.49605362744048 no 1658 0.477682712559805 2517 3334705
SGTC_932 2857-0803 154 µM -0.0567528201641578 0.496339920033449 no 1659 0.477371048688621 2705 674898
SGTC_2823 7987624 58.44 µM -0.0580757951316757 0.496823980165116 no 1660 0.476844127265239 2564 2239440
SGTC_2216 7189485 200 µM -0.0591304042459294 0.497209851943639 no 1661 0.476424120957998 2531 731273
SGTC_1465 k213-0056 144 µM -0.0593314644994275 0.497283418349119 no 1662 0.476344050101803 2499 24048857 YMR208W ERG12
SGTC_2674 ligustilide 100 µM -0.0595272811557559 0.497355066251409 no 1663 0.476266068390043 2564 5319022 A signalling regulator.
SGTC_703 3875-0075 71.8 µM -0.0596435118872716 0.497397594278292 no 1664 0.476219781279293 2536 2850814
SGTC_632 0781-2353 4.65 µM -0.0596794511048196 0.497410744197324 no 1665 0.476205469100615 2574 6811515 YHR007C ERG11
SGTC_668 1682-0499 62.6 µM -0.0597085783146531 0.497421401650415 no 1666 0.476193869710015 2552 682214
SGTC_326 k292-0812 17.5 µM -0.0601004579453615 0.497564787986691 no 1667 0.476037812618291 2493 3579357
SGTC_1453 4237-0541 195 µM -0.0605629725012768 0.497734019609118 no 1668 0.475853631515345 2504 739892
SGTC_2720 fluspirilene 36.88 µM -0.0610539908804253 0.497913681074806 no 1669 0.475658105355537 2572 3396 An atypical antipsychotic.
SGTC_1940 st075990 51.1 µM -0.0623760182696565 0.49839740708407 no 1670 0.4751316962058 2741 1084979
SGTC_1888 azatryptophan 97.5 µM -0.0624701282953406 0.498431841769303 no 1671 0.475094224814987 2619 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1350 1495-0454 146 µM -0.0630046689643822 0.498627429430585 no 1672 0.474881393207061 2574 1069057
SGTC_1102 cgs 12066b 26.1 µM -0.0642827386413815 0.499095074534563 no 1673 0.474372548796925 2587 6438352 A 5-HT1B full agonist.
SGTC_3002 9075603 71.4286 µM -0.0645441196684368 0.49919071390567 no 1674 0.474268488955129 2516 20105405
SGTC_2992 9074591 71.4286 µM -0.0649467599749797 0.49933804016502 no 1675 0.474108195040279 2514 17741321
SGTC_519 k048-0011 62.8 µM -0.0654423456744997 0.499519375304996 no 1676 0.473910904673577 2633 6836379
SGTC_898 1000-0849 28.3 µM -0.0656073358609811 0.499579745348814 no 1677 0.473845224263443 2488 6751807
SGTC_2769 toremifene 3.73 µM -0.0666008226658327 0.499943263135628 no 1678 0.47344974540456 2614 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_482 fipronil 114 µM -0.0669109440206257 0.499943263135628 no 1679 0.473326300248522 2515 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2329 6138490 200 µM -0.0670753060972147 0.499883122880822 no 1680 0.473260876245841 2750 720019
SGTC_3188 9110789 49.47 µM -0.0671595319467933 0.499852304555786 no 1681 0.473227350590769 2561 849217
SGTC_3217 9129673 49.47 µM -0.0683561581510716 0.499414457978895 no 1682 0.472751060442228 2597 17248312
SGTC_3083 9117465 49.47 µM -0.0688891155863197 0.499219448581882 no 1683 0.472538941220334 2614 16420915
SGTC_1225 1216-0074 20.6 µM -0.0689400182421406 0.499200823283213 no 1684 0.472518682163243 2559 4241466
SGTC_2912 7964298 10.93 µM -0.0691727019742628 0.499115684251153 no 1685 0.472426075857793 2577 2975850
SGTC_801 0866-0028 10.1 µM -0.069192420349251 0.499108469294925 no 1686 0.472418228167212 2521 6849771
SGTC_2118 5526350 200 µM -0.0697881389852402 0.498890495909142 no 1687 0.472181143939088 2645 743594
SGTC_1981 st071826 47 µM -0.0698564112862762 0.498865515101356 no 1688 0.472153973542297 2594 11838600
SGTC_1881 5652484 16 µM -0.0725356675635076 0.497885180794097 no 1689 0.471087810801813 2526 2255129
SGTC_2163 5671233 125 µM -0.0726049253832535 0.497859839645529 no 1690 0.471060253589209 2551 701023
SGTC_1001 4048-4355 44.4 µM -0.07400670672404 0.497346935672695 no 1691 0.470502524351738 2541 21824233
SGTC_1452 4194-0072 190 µM -0.0745917716061778 0.497132864944512 no 1692 0.470269760596108 2613 1343545
SGTC_2101 5377231 179.231 µM -0.0746862818497794 0.497098284451105 no 1693 0.470232161342446 2590 2844213
SGTC_2338 7999974 200 µM -0.075143309322099 0.496931062302764 no 1694 0.470050344676681 2629 315925
SGTC_2842 9000675 19.48 µM -0.0753554107700234 0.496853456515307 no 1695 0.469965967670996 2613 2989072
SGTC_675 1309-0189 238 µM -0.0780646850258908 0.495862171791017 no 1696 0.468888299351491 2580 4246530
SGTC_704 1310-0270 142 µM -0.0796933839452881 0.495266266041106 no 1697 0.468240560782508 2615 5718033
SGTC_205 1486-1330 71.903 µM -0.0799252591742153 0.49518142873206 no 1698 0.468148350087541 2537 4118834
SGTC_3117 9124945 49.47 µM -0.0800639555808957 0.495130683312311 no 1699 0.468093194981984 2527 17592065
SGTC_604 1000-0114 314 µM -0.0807515132795736 0.494879124953501 no 1700 0.467819784436079 2574 1572745
SGTC_542 3381-0244 89.3 µM -0.0808016282640581 0.494860789344199 no 1701 0.467799856569269 2611 1112843
SGTC_1682 st012968 530 nM -0.0808123278640032 0.494856874674447 no 1702 0.467795601959973 2576 24207270
SGTC_712 r015-0009 80.6 µM -0.0812777309729459 0.494686597813763 no 1703 0.467610541748337 2618 6813872 YLR060W FRS1
SGTC_934 2950-0684 338 µM -0.0817981036376998 0.494496210410133 no 1704 0.46740363205014 2705 1121253
SGTC_2918 7977171 22.06 µM -0.0821130867005056 0.494380968976304 no 1705 0.467278393293147 2541 2236483
SGTC_732 3970-1727 52.7 µM -0.0821305630308602 0.49437457500371 no 1706 0.467271444716191 2603 1275699
SGTC_1223 0764-0573 147 µM -0.0821593147632337 0.494364055762535 no 1707 0.467260013068834 2565 1609797
SGTC_957 1187-1561 14.1 µM -0.0822039464633614 0.494347726611015 no 1708 0.467242267622681 2527 1538454
SGTC_1431 4049-0260 9.09 µM -0.082667938998808 0.494177968812682 no 1709 0.467057789278615 2533 3854841
SGTC_223 busulfan 5 mM -0.0829892388001499 0.494060417652036 no 1710 0.466930048144962 2643 2478 A DNA alkylator.
SGTC_1970 st070122 35.8 µM -0.0836825450009627 0.493806765519835 no 1711 0.466654417766065 2661 102928
SGTC_3021 9087658 49.47 µM -0.0839624447310519 0.493704362461355 no 1712 0.466543145528373 2557 25237042
SGTC_643 k048-0106 28.4 µM -0.0859402851145824 0.492980769458346 no 1713 0.465756943533131 2666 6763920
SGTC_2835 9006588 71.43 µM -0.0861590876143694 0.492900721928369 no 1714 0.465669976537508 2770 2345538
SGTC_1466 k213-0079 57.5 µM -0.0864473274867901 0.492795271605542 no 1715 0.465555412910234 2545 3657981
SGTC_3 0833-0587 95.581 µM -0.0873757562333776 0.492455616605759 no 1716 0.465186419693663 2525 5382644
SGTC_3310 9130229 44.1445 µM -0.0898628572364215 0.491545766883937 no 1717 0.4641980986621 2696 7761258
SGTC_1257 0669-0121 16 µM -0.0904245960875894 0.491340273334213 no 1718 0.463974905951296 2659 4307855
SGTC_1032 k061-1018 98.7 µM -0.0910008116778339 0.491129486337499 no 1719 0.463745973054153 2776 4005393
SGTC_3052 9092717 49.47 µM -0.0913007631324567 0.49101976125441 no 1720 0.463626805815457 2687 25237534
SGTC_2880 9042983 58.44 µM -0.0915483019318701 0.490929209728471 no 1721 0.463528463975033 2688 6464714
SGTC_3285 9112818 20.8695 µM -0.0915484371473996 0.490929160265757 no 1722 0.46352841025742 2552 17017947 YPR165W RHO1
SGTC_1908 st060353 56.5 µM -0.0925335868478715 0.490568789889258 no 1723 0.463137053619167 2657 4227716
SGTC_2241 6772625 37.8075 µM -0.0936046657301254 0.490176995134449 no 1724 0.462711601586952 2542 2285411
SGTC_96 0929-0093 37.281 µM -0.0945449249323014 0.489833061297351 no 1725 0.4623381486538 2557 6991579
SGTC_1728 st035614 33.7865 µM -0.0953659095775169 0.489532762619903 no 1726 0.462012096424839 2706 15945546
SGTC_2721 ifenprodil 61.44 µM -0.0965258673944797 0.48910848493805 no 1727 0.461551465316774 2633 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_714 4296-0578 26.1 µM -0.0967741109464519 0.489017686497762 no 1728 0.461452891942958 2616 1589775
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0975321516328475 0.488740426395654 no 1729 0.461151901312022 2568 1377
SGTC_1231 0242-0792 125 µM -0.0975915514228479 0.488718700623956 no 1730 0.461128316734579 2571 3707635
SGTC_296 1222-0039 74.9 µM -0.0980166512317066 0.488563219213468 no 1731 0.460959535632068 2610 5984176
SGTC_754 3474-0146 171 µM -0.0981569191832278 0.488511916209175 no 1732 0.460903845359606 2573 24762078
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0987950415078461 0.488278525376378 no 1733 0.460650502768703 2579 6708561
SGTC_940 3232-1287 54.8 µM -0.0988892197601033 0.488244080373916 no 1734 0.460613114167765 2561 1585493 YIL048W NEO1
SGTC_278 4092-0821 23.9 µM -0.09964146336791 0.487968955980939 no 1735 0.460314487300807 2665 877900
SGTC_3213 9129884 49.47 µM -0.100467942152814 0.487666687536753 no 1736 0.459986416246083 2656 17190742
SGTC_2156 5649887 115 µM -0.101847011289605 0.487162335843026 no 1737 0.459439055008185 2694 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_125 0133-0007 11.75 µM -0.102984131847626 0.486746484734108 no 1738 0.458987782468137 2680 26541
SGTC_2651 TUB2.036 5 µM -0.103685832258236 0.486489876278264 no 1739 0.458709335134387 2656 15992207 YFL037W TUB2
SGTC_2260 7964312 200 µM -0.103698426467675 0.486485270687397 no 1740 0.458704337710396 2792 231951
SGTC_2371 9071574 200 µM -0.104180413786554 0.486309013553253 no 1741 0.458513088458696 2573 45596039
SGTC_671 0560-0003 407 µM -0.105731302676419 0.485741889917361 no 1742 0.457897771801859 2689 3238678
SGTC_1217 1183-1422 255 µM -0.10604600220735 0.485626815173561 no 1743 0.457772926726324 2698 2849664
SGTC_1821 st053465 65.6 µM -0.107174229213803 0.485214271449237 no 1744 0.457325379880948 2674 675086
SGTC_1671 st016596 74.5 µM -0.10761561270291 0.485052880916892 no 1745 0.45715030588621 2636 2829167
SGTC_1132 3456-3614 2.5 µM -0.107961479516043 0.484926417476722 no 1746 0.457013124224638 2809 3125502
SGTC_1909 st060837 51.5 µM -0.108381466375971 0.484772854672447 no 1747 0.456846551108223 2653 678937
SGTC_3029 9088683 49.47 µM -0.109557146524707 0.484342994399213 no 1748 0.456380299059912 2722 25236615
SGTC_1762 st045503 25.4615 µM -0.11002527375275 0.484171839535078 no 1749 0.456194665519653 2660 4645554
SGTC_3012 9080433 71.4286 µM -0.110141796972032 0.484129237218996 no 1750 0.456148460297092 2591 17688859
SGTC_1949 st076024 69.1 µM -0.110908090703603 0.483849075381571 no 1751 0.455844614866883 2575 2921930
SGTC_1801 st050089 28.441 µM -0.111702216454702 0.483558746396774 no 1752 0.455529760927232 2589 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2469 5655019 90.81 µM -0.111929397592518 0.483475691539397 no 1753 0.455439693575724 2770 2788239
SGTC_5 0352-0601 109.883 µM -0.113046577740165 0.483067273599868 no 1754 0.454996814083729 2599 762456
SGTC_1261 0712-0010 12.7 µM -0.113107263176439 0.48304508876529 no 1755 0.454972758382847 2664 2840123
SGTC_1922 5578187 25 µM -0.113110794462614 0.483043797831148 no 1756 0.454971358586443 2811 1350412
SGTC_949 1165-0505 146 µM -0.114178581192072 0.482653454691429 no 1757 0.45454811529515 2614 6244267
SGTC_730 1436-0052 41.2 µM -0.114388882550347 0.482576578279579 no 1758 0.454464763293765 2610 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_431 k089-0097 107 µM -0.115005412477439 0.482351207309018 no 1759 0.454220415987809 2595 5499420
SGTC_1936 st074407 74.3 µM -0.115043687550058 0.482337216137277 no 1760 0.454205247122655 2605 809813
SGTC_1499 4480-0877 67.3 µM -0.11616435672056 0.481927573465566 no 1761 0.453761142340811 2613 2861909
SGTC_2885 9057732 51.95 µM -0.116915658066881 0.48165295794469 no 1762 0.453463444954523 2730 6471414
SGTC_2283 7944793 200 µM -0.119310483304013 0.480777660627942 no 1763 0.452514689175651 2670 2970533
SGTC_1045 1348-1485 165 µM -0.119403452124782 0.480743682804218 no 1764 0.452477863231533 2596 6810614
SGTC_1941 st076221 61.8 µM -0.120958766599122 0.480175274450406 no 1765 0.451861847404521 2786 2828568
SGTC_762 1165-0429 115 µM -0.121309250962564 0.480047191254462 no 1766 0.451723046463042 2683 5967793
SGTC_141 0443-0274 32.331 µM -0.121608630806712 0.479937785644305 no 1767 0.451604488915631 2661 1627241
SGTC_189 3970-0742 2.116 µM -0.124189881592421 0.47899455484701 no 1768 0.450582466768529 2632 2891807
SGTC_2051 5263410 176 µM -0.124588460559773 0.478848917995235 no 1769 0.450424682175525 2607 227584
SGTC_2049 5262831 67.185 µM -0.124596558094453 0.478845959264558 no 1770 0.450421476703122 2667 763417
SGTC_962 1254-0300 21.5 µM -0.125467858107392 0.478527604758758 no 1771 0.450076584720826 2619 7340576
SGTC_1562 morin hydrate 59.1 µM -0.126338634188944 0.47820945537341 no 1772 0.449731937797004 2779 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_254 nsc-64875 3.808 µM -0.12814786147299 0.477548475243757 no 1773 0.449015980138696 2777 56993
SGTC_2040 5100729 123 µM -0.129977685475917 0.476880033164285 no 1774 0.448292040658642 2635 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_97 0535-0701 19.132 µM -0.131229463318693 0.476422791031664 no 1775 0.447796894568889 2669 2832013 YGL099W LSG1
SGTC_251 melphalan 456.522 µM -0.1335531776005 0.475574080939805 no 1776 0.446877955624742 2706 460612 A DNA alkylator.
SGTC_551 k048-0028 34.9 µM -0.133819240394229 0.475476911542153 no 1777 0.446772756202296 2768 6836383
SGTC_1392 3455-1037 33.9 µM -0.13389690352544 0.47544854828822 no 1778 0.446742049433329 2777 981132
SGTC_3233 9132340 49.47 µM -0.135761739565493 0.474767531566586 no 1779 0.446004819178174 2655 17682950
SGTC_3263 9137018 49.47 µM -0.136181200511575 0.474614359327528 no 1780 0.445839018262658 2670 43844957
SGTC_1998 st075797 76.8 µM -0.137123017146308 0.474270455048914 no 1781 0.445466779631039 2612 24208315
SGTC_1695 st026914 34.495 µM -0.138063902152426 0.473926910097966 no 1782 0.445094957209538 2633 3289191
SGTC_2094 5332512 191.667 µM -0.138304735177722 0.473838977942046 no 1783 0.44499979167313 2775 755774
SGTC_2117 5521686 200 µM -0.138542343742626 0.473752224339505 no 1784 0.444905903393508 2659 803312
SGTC_1460 k062-0059 9.15 µM -0.138911896453889 0.47361729889628 no 1785 0.444759885052063 2581 1373085
SGTC_1370 2001-0092 44.6 µM -0.139048865599464 0.473567291581158 no 1786 0.444705767456277 2755 790957
SGTC_1568 digitonin 820 nM -0.139529643285943 0.473391763371127 no 1787 0.444515816544039 2698 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_500 h-89 112 µM -0.140800109901973 0.472927950801324 no 1788 0.444013928120702 2836 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2251 lansoprazole 556 µM -0.141983869816919 0.472495825490801 no 1789 0.443546373310692 2664 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1715 st032160 10.2275 µM -0.142835130558009 0.472185097228487 no 1790 0.443210195681108 2735 5289825
SGTC_2398 5228213 48.84 µM -0.143555525911861 0.471922150830712 no 1791 0.442925730983969 2731 80771 YMR134W ERG29
SGTC_1455 4262-0120 131 µM -0.14388864796636 0.47180056444356 no 1792 0.442794200006237 2850 1529587
SGTC_2295 7971645 200 µM -0.14394319223815 0.471780656552293 no 1793 0.44277266417173 2745 2978226 YKL099C UTP11
SGTC_2783 7738165 71.43 µM -0.144166074353351 0.471699308451456 no 1794 0.442684664894919 2723 17201110
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.144361455017467 0.471627998873607 no 1795 0.442607526185084 2763 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_214 4373-3496 70 µM -0.145043690291779 0.471379005386583 no 1796 0.442338188317207 2693 3779166
SGTC_1131 3454-3128 32.3 µM -0.145520108776335 0.471205134901721 no 1797 0.442150120114086 2852 710982
SGTC_3205 9113483 49.47 µM -0.146104329233755 0.470991929229224 no 1798 0.441919514429585 2840 17018033
SGTC_1527 coumarin 137 µM -0.146315101961444 0.470915011774271 no 1799 0.44183632225753 2894 323 A hepatotoxic, DNA x-linker.
SGTC_1157 4092-0394 27.6 µM -0.147241870055305 0.470576818487544 no 1800 0.441470556604655 2846 3659885
SGTC_738 1315-0003 72.4 µM -0.148873174100153 0.46998157986521 no 1801 0.440826854631179 2794 6251474
SGTC_161 4065-0411 162.148 µM -0.14912724259803 0.469888880046091 no 1802 0.440726614878784 2795 1906281 YLR208W SEC13
SGTC_2073 5212005 126 µM -0.149283917828124 0.469831716096164 no 1803 0.44066480239309 2644 691789
SGTC_2817 7995342 71.43 µM -0.149773091861744 0.469653241858616 no 1804 0.440471819722864 2671 18879975
SGTC_2112 5488546 200 µM -0.150961730275694 0.469219594818468 no 1805 0.440002952336038 2674 600757
SGTC_1246 0422-0085 105 µM -0.151806609101966 0.468911382626004 no 1806 0.439669734622575 2754 264295
SGTC_1151 3909-8316 15.3 µM -0.151869060192298 0.468888601176118 no 1807 0.43964510579035 2777 800431
SGTC_2333 9017922 200 µM -0.152591427623012 0.468625097147844 no 1808 0.43936024279739 2815 3163164
SGTC_1010 4112-3296 15.2 µM -0.152919497822296 0.468505428760239 no 1809 0.439230879855821 2828 704384
SGTC_2290 7904846 200 µM -0.153691545350155 0.468223824416883 no 1810 0.438926475704448 2751 2962154
SGTC_3212 9128307 49.47 µM -0.154361587623781 0.467979439373025 no 1811 0.438662319618708 2702 27243542
SGTC_192 3455-0609 60.9 µM -0.157017838206232 0.467010742647718 no 1812 0.437615394813998 2800 3769639
SGTC_455 paf C-16 10 µM -0.15748443106957 0.466840602891082 no 1813 0.437431538497729 2669 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1841 st054148 70 µM -0.157902476361288 0.466688170804951 no 1814 0.437266823346298 2762 675442
SGTC_2188 6126565 140.678 µM -0.158144134411369 0.466600057123456 no 1815 0.437171611964379 2751 874518
SGTC_834 0312-0008 75.7 µM -0.159473086914347 0.466115522053113 no 1816 0.436648080241151 2668 6385573 YIL048W NEO1
SGTC_821 1114-0266 29.2 µM -0.159570733745921 0.466079922064566 no 1817 0.436609617305913 2761 3123235
SGTC_2897 9048598 12.99 µM -0.160088685695326 0.46589109218267 no 1818 0.436405606866926 2705 6467404
SGTC_399 oxolinic acid 75 µM -0.161472702856831 0.465386558461349 no 1819 0.435860554590968 2689 4628 A DNA gyrase inhibitor.
SGTC_2350 9023895 38.85 µM -0.162470566434284 0.465022828782394 no 1820 0.435467652443511 2826 2997209
SGTC_3334 9142812 21.919 µM -0.162760252228598 0.464917241330103 no 1821 0.435353602500911 2820 45283678
SGTC_701 4424-0219 185 µM -0.16416624532131 0.464404806728394 no 1822 0.434800136442004 2795 2911779
SGTC_2199 6590217 200 µM -0.164934270057935 0.464124913836847 no 1823 0.434497859086684 2733 703109
SGTC_973 1325-0077 65.9 µM -0.165496494366734 0.463920032480823 no 1824 0.434276604439262 2779 2835149
SGTC_2301 7769476 200 µM -0.166108230762762 0.463697119190199 no 1825 0.434035888466023 2785 977820
SGTC_532 1548-0774 215 µM -0.167469579889446 0.463201092253412 no 1826 0.433500290608221 2912 5932993
SGTC_1284 0929-0043 16 µM -0.169497122164794 0.462462434638008 no 1827 0.432702817896075 2772 1239883
SGTC_3270 9137563 49.47 µM -0.170114031569969 0.462237712814797 no 1828 0.43246022937809 2826 17015724
SGTC_822 1487-0950 154 µM -0.172226878730024 0.461468156947005 no 1829 0.431629583714985 2754 1958375
SGTC_1087 pterostilbene 9.05 µM -0.172279874537499 0.461448856288383 no 1830 0.431608752790015 2834 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.172948368378837 0.46120540387067 no 1831 0.431346005994139 2714 66535 A nucleotide analog.
SGTC_760 0568-0725 82.9 µM -0.17458465010918 0.460609563508012 no 1832 0.430703005387374 2870 3916171
SGTC_1076 itraconazole 331 nM -0.174623624801219 0.460595372223876 no 1833 0.430687691950382 2700 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2238 6671620 73.2395 µM -0.176562020968953 0.459889636087313 no 1834 0.429926214097921 2669 729941
SGTC_3035 9091303 49.47 µM -0.176990085175199 0.459733802352873 no 1835 0.429758088758057 2722 25237002
SGTC_3038 9091290 49.47 µM -0.177613226238216 0.459506963336833 no 1836 0.42951336833438 2845 25236843
SGTC_18 0111-0177 500 nM -0.178161927052356 0.459307233354319 no 1837 0.429297904561633 2743 721752
SGTC_2062 5245942 200 µM -0.180414621142241 0.458487349035737 no 1838 0.428413538324946 2690 1376160
SGTC_591 4299-0174 154 µM -0.182076476325288 0.457882617796776 no 1839 0.427761354658993 2761 5509088
SGTC_1495 4469-0029 237 µM -0.182859765493201 0.457597621004927 no 1840 0.427454026508758 2718 793680
SGTC_2847 9005661 71.43 µM -0.184623698102034 0.456955900871389 no 1841 0.426762098537963 2715 2991449
SGTC_2374 9071832 200 µM -0.185731339091485 0.456552997424464 no 1842 0.426327725430759 2726 17381698
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.186055151377406 0.456435219405578 no 1843 0.426200755880405 2781 676296 Flavone; oxidizing agent.
SGTC_1860 st056228 74.6 µM -0.186399745517708 0.456309886749421 no 1844 0.426065645989996 2849 688679
SGTC_1829 berberine 14.4 µM -0.187404806658263 0.455944359897176 no 1845 0.425671627100596 2895 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2815 7968870 71.43 µM -0.188076797196989 0.455699987000335 no 1846 0.425408224831099 2757 2977326 YHR190W ERG9
SGTC_1310 1188-0297 994 nM -0.188357973006679 0.45559774090491 no 1847 0.425298021326041 2794 1588352
SGTC_2013 4024628 200 µM -0.189100687622129 0.455327676108951 no 1848 0.425006951282443 2892 5230760
SGTC_1176 0848-0131 83.3 µM -0.189141492589283 0.4553128392639 no 1849 0.424990960988792 2840 6769040
SGTC_172 1112-0046 2.638 µM -0.189353295628355 0.455235827855491 no 1850 0.424907963449626 2796 2802135 YIL048W NEO1
SGTC_2114 5491910 81.25 µM -0.189646977228542 0.45512904825445 no 1851 0.424792886330997 2857 2849228
SGTC_1832 st054113 55 µM -0.190603242796596 0.454781382459142 no 1852 0.42441822469424 2747 1251267
SGTC_2104 5389443 200 µM -0.19095536262465 0.45465337231804 no 1853 0.424280282511885 2915 2244536
SGTC_1880 MG-132 525 µM -0.192242429789332 0.454185510262642 no 1854 0.423776155761639 2838 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_770 0389-1121 67.2 µM -0.192579468964969 0.454063003556576 no 1855 0.423644162661797 2919 6753108
SGTC_370 0180-0345 38.7 µM -0.193110999244798 0.453869812278461 no 1856 0.423436019321171 2680 3989527
SGTC_737 1950-0117 57.9 µM -0.193238426820369 0.453823498764603 no 1857 0.423386122794242 2797 5393513
SGTC_3311 9131146 2.8755 µM -0.193533933982411 0.453716099193377 no 1858 0.423270416454253 2810 4900406 YPR165W RHO1
SGTC_1661 st013063 9.66 µM -0.195599324207389 0.452965545569976 no 1859 0.422461894633626 2757 721395
SGTC_1660 st012960 28.1 µM -0.195758280454152 0.452907788505151 no 1860 0.422399682792358 2837 24207266
SGTC_289 k017-0060 526 µM -0.195884890857481 0.452861785078895 no 1861 0.422350131759736 2760 5512909
SGTC_817 1391-0715 46 µM -0.197608202380085 0.452235689317911 no 1862 0.421675808392863 2817 1353946
SGTC_1373 2887-0003 58.5 µM -0.198854715382675 0.451782893002307 no 1863 0.421188196941182 2855 776948
SGTC_605 1315-0399 119 µM -0.199082584103479 0.451700126367124 no 1864 0.421099072208435 2869 24020461
SGTC_3181 9108277 49.47 µM -0.199260308198313 0.451635574754889 no 1865 0.42102956300608 2772 17097298
SGTC_881 0833-0569 170 µM -0.200176479706179 0.451302830138046 no 1866 0.42067128067941 2783 5418700
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.200321719511645 0.451250083583477 no 1867 0.420614488545869 2840 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3026 9090633 49.47 µM -0.201629946572049 0.450775015338547 no 1868 0.420103016022516 2748 25236842
SGTC_1241 0364-0022 50.8 µM -0.202748963287795 0.450368712669583 no 1869 0.419665625353479 2832 4563895
SGTC_2034 5197015 53.07 µM -0.204267740150525 0.449817344763982 no 1870 0.41907213904517 2909 780676
SGTC_79 0052-0007 94.094 µM -0.207423314822965 0.44867207421398 no 1871 0.417839637963126 2943 2801472
SGTC_3030 9087619 49.47 µM -0.209344250844771 0.447975106806626 no 1872 0.417089754901282 2821 25236973
SGTC_812 4251-0442 148 µM -0.209514429724407 0.447913369029981 no 1873 0.417023336027596 2776 5723007
SGTC_2128 5255449 168.493 µM -0.210043645817525 0.447721387205873 no 1874 0.41681680416984 2776 736008
SGTC_2232 chlorophetanol 41.5365 µM -0.210085770540314 0.447706106296855 no 1875 0.416800365562344 2793 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_707 0865-0008 204 µM -0.210391805102044 0.447595093386364 no 1876 0.416680944052818 2805 723043
SGTC_154 3389-1638 511.116 µM -0.210520948679139 0.44754824826038 no 1877 0.416630551655894 2886 5238686
SGTC_2441 5730946 39.09 µM -0.211321972251365 0.447257703912687 no 1878 0.416318019336734 2913 1774275
SGTC_451 chloral hydrate 100 µM -0.211412423712866 0.447224897464046 no 1879 0.416282731554556 2891 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2458 5808907 16.39 µM -0.212103093771561 0.446974405618988 no 1880 0.416013303067885 2884 2731747
SGTC_2801 7907800 81.82 µM -0.212292066660661 0.446905872714623 no 1881 0.415939592135853 2872 6620925
SGTC_1362 1611-0397 101 µM -0.214654483266502 0.44604925321351 no 1882 0.415018356192717 2805 27816
SGTC_301 4119-0100 24.5 µM -0.214895135556403 0.445962006017496 no 1883 0.414924538780856 2804 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_257 daunorubicin 18.5 µM -0.215642697836155 0.445690998032028 no 1884 0.41463313533743 2894 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1553 gossypol 38.6 µM -0.215830489542786 0.44562292333612 no 1885 0.414559940584901 2747 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1395 3486-0190 4.35 µM -0.215909162293861 0.445594404855494 no 1886 0.414529277532247 2914 6748079
SGTC_1112 tnp00069 1.16933 µM -0.216173387830804 0.445498626474917 no 1887 0.414426298273888 2893 145826
SGTC_45 0kpi-0036 14.9 µM -0.216452237001553 0.445397550663865 no 1888 0.414317625979924 2908 2795021
SGTC_286 k060-0067 22.9 µM -0.217007954731351 0.445196127554682 no 1889 0.414101072838895 2813 5985051
SGTC_2949 9072542 2.23 µM -0.217537330170207 0.445004265517983 no 1890 0.413894809097177 2894 16457352
SGTC_1301 naphtanilide LB 4.81 µM -0.219714924650762 0.444215173879155 no 1891 0.413046590243964 2923 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1619 st003326 88.7 µM -0.221908402435395 0.443420550131414 no 1892 0.412192594702116 2957 2849032
SGTC_1546 5-methoxyflavanone 78.7 µM -0.222200700449867 0.443314677428386 no 1893 0.412078824433132 2877 147795
SGTC_1518 st038567 90.8 µM -0.222561891822887 0.443183856584523 no 1894 0.411938249218888 2767 77966
SGTC_1815 st051655 58.2 µM -0.222645717128655 0.443153496563654 no 1895 0.411905626133462 2882 5984156
SGTC_1892 st058411 7.36 µM -0.222679921521477 0.443141108442493 no 1896 0.411892314661964 2928 3934738
SGTC_2307 7538926 6.34 µM -0.22401952992766 0.442655973914866 no 1897 0.41137105335661 2853 96582
SGTC_702 1488-0190 94 µM -0.224559981246278 0.442460275645851 no 1898 0.411160800039919 2882 949357
SGTC_157 1348-1695 65.819 µM -0.22507448307527 0.442273986771563 no 1899 0.410960665633577 2802 5380510
SGTC_904 1141-0088 396 µM -0.226145774089415 0.441886138783058 no 1900 0.410544022020376 2848 1378119
SGTC_2699 st077704 54.6 µM -0.227402375227486 0.441431272520449 no 1901 0.410055436751084 2860 645852
SGTC_1367 1812-0510 76.9 µM -0.227852881348383 0.441268216453652 no 1902 0.409880307206638 2855 1142582 YDR527W RBA50
SGTC_2797 7859098 81.82 µM -0.228076334584006 0.441187343539925 no 1903 0.409793448764715 2836 972681
SGTC_101 0490-5701 117.494 µM -0.232137234074242 0.439718040299417 no 1904 0.408215713016668 2775 4661669
SGTC_2313 7726885 200 µM -0.232779483540049 0.439485738892634 no 1905 0.407966322549242 2931 726423
SGTC_3330 9141424 71.43 µM -0.233139213805161 0.439355633680288 no 1906 0.407826652769593 2949 27261020
SGTC_2223 6903751 107.57 µM -0.233178477310913 0.439341433473346 no 1907 0.407811408930558 2913 5598863
SGTC_1515 3460-0031 42.1 µM -0.234101287436146 0.439007708542456 no 1908 0.407453173235998 2839 2876596
SGTC_467 ro 31-8220 72.8 µM -0.234558406808708 0.438842411994415 no 1909 0.407275747738955 2881 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1602 st001878 87.6 µM -0.235370419477143 0.438548810654518 no 1910 0.406960621522832 3003 595405 YLR310C CDC25
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.236105730353871 0.438282971732335 no 1911 0.406675313723011 2840 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.237437492443089 0.437801567165103 no 1912 0.406158703214307 2916 6708739 YPR165W RHO1
SGTC_2451 5856223 45.7 µM -0.238695062726386 0.437347065889788 no 1913 0.405671022742712 2867 2179896
SGTC_2998 9066762 71.4286 µM -0.238865205352349 0.437285580600041 no 1914 0.40560505337221 2990 4945196
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.239431039328754 0.437081113254647 no 1915 0.405385681957853 2988 5377381
SGTC_3264 9137442 49.47 µM -0.239697414038954 0.436984863043165 no 1916 0.405282419905263 3072 17015726
SGTC_2686 alizarin 95.37 µM -0.240702636804929 0.436621675628834 no 1917 0.40489279758722 2894 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1790 st045711 43.5 µM -0.242516561086672 0.43596643938166 no 1918 0.404189962958711 2994 585119
SGTC_2359 9039622 200 µM -0.244181151630577 0.435365300894502 no 1919 0.403545262065471 2821 6463596
SGTC_756 0508-1999 28.3 µM -0.246297023155183 0.434601405701106 no 1920 0.402726157081284 2856 6753853
SGTC_1005 4092-0690 4.4 µM -0.246525359341825 0.434518983802676 no 1921 0.402637788077438 2900 1529343
SGTC_2327 6189656 200 µM -0.247365782696999 0.434215642989294 no 1922 0.402312576447072 2962 5349088
SGTC_626 0214-0009 33 µM -0.247800842102267 0.43405862867496 no 1923 0.402144251672245 2955 3437874
SGTC_2164 5685496 200 µM -0.248518244859294 0.433799738485249 no 1924 0.401866727711265 2879 759046
SGTC_639 0833-0042 114 µM -0.252019318837763 0.432536710225613 no 1925 0.400513065689221 2867 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2219 9098279 200 µM -0.252310476928632 0.432431704484641 no 1926 0.400400545317988 2897 902349
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.252670378197397 0.432301913212765 no 1927 0.40026147002062 2972 688662
SGTC_1275 0867-0008 21.1 µM -0.253110904001387 0.432143056242192 no 1928 0.400091256501534 2834 3422836
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.253250265217684 0.432092803805814 no 1929 0.400037413065502 2877 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3281 9140613 49.47 µM -0.253643247308173 0.431951103819041 no 1930 0.399885591203781 2886 16013766
SGTC_2132 5317594 122.667 µM -0.254490891517888 0.431645493324329 no 1931 0.399558170013863 2841 794577
SGTC_1779 st039427 55 µM -0.254506255398214 0.431639954392398 no 1932 0.399552236028673 3051 1124498
SGTC_159 3970-0959 50 µM -0.254605583539312 0.431604145285778 no 1933 0.39951387312149 2938 6615653
SGTC_86 0417-1630 471.922 µM -0.254996169532296 0.431463339330431 no 1934 0.39936302886734 2892 3634867
SGTC_1607 st000305 50.6 µM -0.25541672039993 0.431311740797202 no 1935 0.399200628979574 3005 5457690
SGTC_2521 angolensin 13.4 µM -0.256104201303378 0.431063942166629 no 1936 0.398935188988166 3004 821428 A flavenoid.
SGTC_652 0437-0092 114 µM -0.257992633857403 0.430383407176994 no 1937 0.398206296085712 2873 3091274
SGTC_1673 st016611 27.3 µM -0.260306682351594 0.429549774894175 no 1938 0.397313609233095 3069 5226799
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.261002728042178 0.429299086811627 no 1939 0.397045201741737 2876 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_528 3492-0019 172 µM -0.262079535447003 0.428911319650886 no 1940 0.39663006192323 2936 2869262
SGTC_2476 5806916 10.51 µM -0.262366697826991 0.428807921698833 no 1941 0.39651937244121 2861 2870194
SGTC_1365 1672-3266 55.4 µM -0.263855400477056 0.428271966151062 no 1942 0.395945671654009 2984 6415873
SGTC_650 1328-0195 38 µM -0.263974752885033 0.428229003187432 no 1943 0.395899686600925 2929 2780821
SGTC_1067 clotrimazole 1.36 µM -0.264678786678657 0.427975591372015 no 1944 0.395628460312717 2883 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1341 1486-1360 280 µM -0.265213257859824 0.427783232207138 no 1945 0.395422591101529 2850 3976547
SGTC_439 amiodarone 34.4 µM -0.266612847607078 0.427279593467622 no 1946 0.394883631320631 2928 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3166 9102297 49.47 µM -0.267011836553558 0.427136040000058 no 1947 0.394730023803197 2925 25237072
SGTC_828 2074-0507 139 µM -0.267125932111344 0.427094990979507 no 1948 0.394686100943997 3016 X828
SGTC_2353 9059630 146.67 µM -0.268667856787813 0.426540318693417 no 1949 0.394092644568947 2988 4779114
SGTC_2812 7970281 58.44 µM -0.270447062710959 0.425900470447104 no 1950 0.393408168853991 3020 2233435
SGTC_476 mead acid 10 µM -0.272072031453425 0.425316260227783 no 1951 0.392783317146793 2882 5312531 An omega 9 fatty acid.
SGTC_2717 st081029 62.2815 µM -0.273787441603543 0.424699712337673 no 1952 0.392123987575039 3003 5292846
SGTC_722 3534-0461 190 µM -0.273867909323706 0.424670795366762 no 1953 0.392093066846643 2936 658262
SGTC_120 rhodamine 6G 52.259 µM -0.274167168352401 0.424563256862388 no 1954 0.391978078800933 2868 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2362 9071156 126 µM -0.274329486231196 0.424504930404276 no 1955 0.39191571331448 3059 653133
SGTC_1448 4255-0083 152 µM -0.274762335783581 0.424349400594055 no 1956 0.391749418210562 3039 5399660
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.275311624804988 0.424152049170266 no 1957 0.391538417070089 3236 5282309
SGTC_1756 st041558 35.5 µM -0.275493395631546 0.424086745785403 no 1958 0.391468599556236 3086 3955792
SGTC_355 1311-2252 105 µM -0.275665860073864 0.42402478775944 no 1959 0.39140235982294 2902 5338538
SGTC_2158 5657123 3.6195 µM -0.27613473062461 0.423856355034655 no 1960 0.391222293059344 2859 2858827
SGTC_2407 paclitaxel 400 µM -0.278114559837096 0.423145293201003 no 1961 0.390462209673735 3124 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1947 st076332 61.6 µM -0.278453071543044 0.42302374065663 no 1962 0.390332292230728 2986 24208416
SGTC_2085 5307070 144.047 µM -0.279782272879965 0.422546522958525 no 1963 0.389822276482698 2867 2840351
SGTC_2397 5161689 200 µM -0.279901280854505 0.422503801547594 no 1964 0.389776622252893 3109 2259942
SGTC_2375 9072683 200 µM -0.280473074250827 0.422298552219564 no 1965 0.389557290210279 3073 16798029
SGTC_496 calpeptin 138 µM -0.280584013546234 0.422258732208395 no 1966 0.389514739502121 2951 73364 A calpain inhibitor.
SGTC_2681 menadione 3.18 µM -0.281275579153353 0.422010522943957 no 1967 0.389249519760423 2987 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3090 9117696 49.47 µM -0.283505115377966 0.421210533240797 no 1968 0.388394830475125 2971 7923821
SGTC_2175 5807670 165.306 µM -0.28358005444815 0.421183649653326 no 1969 0.388366112057281 3039 241186
SGTC_1903 st060211 78.3 µM -0.284844107247121 0.420730239743615 no 1970 0.387881789319875 3076 688960
SGTC_2001 4023502 57.655 µM -0.284862213662779 0.420723745818186 no 1971 0.38787485309863 3028 108941 YCR052W RSC6
SGTC_426 0988-0037 14.6 µM -0.285180557128207 0.420609574414557 no 1972 0.387752907656663 3105 5383008
SGTC_1876 myriocin 605 nM -0.286562868657914 0.4201138967299 no 1973 0.387223524499695 3084 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1484 3473-2379 286 µM -0.287312218089992 0.419845243348465 no 1974 0.386936634095868 2941 671917
SGTC_2162 5663267 200 µM -0.287334978734853 0.419837083888463 no 1975 0.38692792108872 3070 6456493
SGTC_969 1313-0238 134 µM -0.2878374833015 0.419656949890195 no 1976 0.386735571735869 2920 5212874
SGTC_1503 4585-0012 61.3 µM -0.287868930522705 0.419645677489884 no 1977 0.38672353525205 3096 2922052
SGTC_1060 3448-7350 82 µM -0.288100717911181 0.419562594274679 no 1978 0.386634821549641 3039 570178
SGTC_1713 st033146 12.748 µM -0.289280359941366 0.419139812183989 no 1979 0.386183420311532 3058 674619
SGTC_2511 berberine 10.47 µM -0.290053221113635 0.418862870380553 no 1980 0.385887761106802 2925 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_166 k072-0058 166.424 µM -0.29006339784568 0.418859223987648 no 1981 0.385883868424344 3011 5846229
SGTC_1433 4060-0023 7.6 µM -0.291208798693322 0.418448863622995 no 1982 0.38544581683561 3039 3840627
SGTC_356 1634-0012 32.5 µM -0.292032421643976 0.418153840772722 no 1983 0.385130917508325 3041 735457
SGTC_953 1188-0045 9.7 µM -0.292748145748712 0.417897504819807 no 1984 0.384857333106733 3033 6144426
SGTC_2110 5483698 200 µM -0.293810899493482 0.41751694488157 no 1985 0.384451202956429 2982 2848765 YHR062C RPP1
SGTC_2344 7990960 76.95 µM -0.293949329887548 0.417467380222158 no 1986 0.384398311261306 2946 140813
SGTC_3146 9095609 49.47 µM -0.294123522244448 0.417405012943897 no 1987 0.384331758639258 2980 17173999
SGTC_3101 9120531 49.47 µM -0.294377667472348 0.417314023321337 no 1988 0.384234665023396 3136 24824904
SGTC_31 0508-1974 57.237 µM -0.294690200695777 0.417202135573682 no 1989 0.384115274823172 3035 6810525
SGTC_2754 granisetron 64.02 µM -0.294891058080352 0.417130231619947 no 1990 0.384038551493157 3067 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1741 st038134 10.228 µM -0.295945135910788 0.416752932939785 no 1991 0.383635990320198 3162 1272587
SGTC_283 0987-0079 11.7 µM -0.296035099709814 0.416720734667845 no 1992 0.383601638199732 3027 411556
SGTC_2871 9038510 12.99 µM -0.297084750846776 0.416345103203946 no 1993 0.383200903076807 3121 4945164
SGTC_3211 9128781 49.47 µM -0.29801109402694 0.416013662556815 no 1994 0.382847348161014 3043 17194361
SGTC_922 1866-0035 480 µM -0.298265531602775 0.415922636594883 no 1995 0.382750254726056 2928 3156169
SGTC_534 k292-0788 63.4 µM -0.299267876264095 0.415564088099393 no 1996 0.382367831524504 3101 4146317
SGTC_2159 5658611 73.75 µM -0.299452550266035 0.415498036060739 no 1997 0.382297385605026 3039 793844
SGTC_396 dithiazanine 1.25 µM -0.299969093114445 0.415313297736915 no 1998 0.382100365375257 2946 10578 An antihelmenthic.
SGTC_3137 9097352 49.47 µM -0.301049761897929 0.414926863892054 no 1999 0.38168827452435 3231 44120435
SGTC_1368 1852-0141 284 µM -0.301437015051445 0.414788406945452 no 2000 0.38154063608696 3042 2838987
SGTC_2539 epi(13)torulosol 80 µM -0.303157458878653 0.4141734145282 no 2001 0.380884933625901 3050 6708597
SGTC_3013 9080133 71.4286 µM -0.308167876857853 0.412383586806067 no 2002 0.378977297155283 3165 17050193
SGTC_1249 0481-0015 10.2 µM -0.308621678881656 0.412221568443905 no 2003 0.378804664005498 2910 4227577
SGTC_3322 9139058 2.11 µM -0.309010402652058 0.41208279649506 no 2004 0.378656806830035 3138 4908926 YPR165W RHO1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.310007607130072 0.411726851059593 no 2005 0.378277585750054 2989 688788
SGTC_478 N-arachidonylglycine 10 µM -0.310033823977969 0.411717494110488 no 2006 0.378267617477562 3046 5283389
SGTC_463 ikarugamyin 104 µM -0.310160518091443 0.411672276934668 no 2007 0.378219446487962 2986 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_524 r073-0010 27.8 µM -0.311215239255631 0.411295892146137 no 2008 0.377818499324145 2931 2772106
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.312098732218704 0.410980674177001 no 2009 0.377482744996116 2999 688801
SGTC_1481 3346-2004 36 µM -0.313503826620746 0.410479474551352 no 2010 0.376948956950441 3003 2770522
SGTC_373 0844-0104 25.9 µM -0.313841720880506 0.410358968848891 no 2011 0.376820627708568 3100 5375804
SGTC_1135 dihydrocapsaicin 536.708 nM -0.314481078391781 0.410130973267205 no 2012 0.376577842644379 2905 107982 A Capsaicinoid.
SGTC_2960 9079389 5.97 µM -0.314584601586437 0.410094059639115 no 2013 0.376538536073485 3121 16457355
SGTC_332 4112-0506 40.9 µM -0.314625192362153 0.410079586261462 no 2014 0.376523124570344 2954 2790355
SGTC_651 3253-0966 34.4 µM -0.315355707374253 0.40981912883653 no 2015 0.376245796344255 2967 781462
SGTC_784 4579-0127 173 µM -0.316314817062423 0.409477228818017 no 2016 0.375881782856269 3153 1948547
SGTC_219 mitoxanthrone 164.414 µM -0.316362824969151 0.409460116936649 no 2017 0.375863565185167 3002 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1315 1237-0019 3.69 µM -0.317719660240847 0.408976559628732 no 2018 0.375348798332969 3085 825140
SGTC_1851 st056236 18.9 µM -0.318147065474911 0.408824266970448 no 2019 0.37518669187985 3139 5393171
SGTC_2515 chrysin 20.77 µM -0.318186820307039 0.408810102262862 no 2020 0.375171614768916 3036 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1477 0139-0234 16 µM -0.318334770066847 0.408757388583356 no 2021 0.375115506160162 2985 620880
SGTC_818 4072-2707 53.5 µM -0.319168461148844 0.408460379951554 no 2022 0.374799385785662 2907 882871
SGTC_2617 dihydrotanshinone i 20.83 µM -0.319336217791609 0.408400621751584 no 2023 0.37473578570034 2968 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_124 0136-0217 7.121 µM -0.319363629234526 0.408390857461461 no 2024 0.374725393767353 3122 3976905
SGTC_2363 9053361 176 µM -0.319863643182114 0.408212756384855 no 2025 0.374535849800545 3138 6469797 YMR079W SEC14
SGTC_3177 9107506 49.47 µM -0.320097248483343 0.408129554490775 no 2026 0.374447305706458 3070 8897194
SGTC_3104 9120930 49.47 µM -0.32031743871874 0.40805113435774 no 2027 0.374363852424932 3060 17014836
SGTC_1772 st048439 82.2 µM -0.323728179348612 0.406836880918078 no 2028 0.373071917354778 3068 2927068 YDL195W SEC31
SGTC_1153 4055-0057 267 µM -0.324552007499249 0.406543724666014 no 2029 0.372760077430008 2961 882706
SGTC_2285 7945142 200 µM -0.325533563664634 0.406194509855997 no 2030 0.372388642289503 3092 2970608
SGTC_566 0958-0068 16.5 µM -0.325994034333521 0.406030710816762 no 2031 0.372214434358394 3145 6815365
SGTC_2978 9011784 42.97 µM -0.327653551591559 0.40544052249975 no 2032 0.371586813347082 3088 2994934
SGTC_92 0063-0024 660.874 µM -0.328424446271103 0.405166435658671 no 2033 0.371295380848239 2963 3594437
SGTC_2508 celastrol 40.54 µM -0.328810423689792 0.405029221235357 no 2034 0.37114949191238 3014 122724 Celastrol is a natural product and antioxidant.
SGTC_1524 corynanthine 62.1 µM -0.330216137137241 0.404529590909229 no 2035 0.370618327215334 3153 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3298 9116858 71.43 µM -0.33147888180345 0.404080908404242 no 2036 0.370141395031866 3136 2506942
SGTC_1620 st003704 16.5 µM -0.332918824199411 0.403569417410428 no 2037 0.36959777977951 3110 2834414
SGTC_755 1995-0008 37.3 µM -0.333321083464143 0.403426557795254 no 2038 0.369445963086376 3110 689533
SGTC_2991 9074669 71.4286 µM -0.33640028040974 0.40233343032826 no 2039 0.368284519027873 3179 17333109
SGTC_1022 4477-0945 21.3 µM -0.336932584278578 0.402144537430781 no 2040 0.36808386065566 2990 4648966
SGTC_2962 9082311 13.18 µM -0.337254862197604 0.402030185265773 no 2041 0.367962391587213 2950 16459453
SGTC_2406 ethylparaben 405.7 µM -0.33731592149897 0.402008520862247 no 2042 0.367939379346152 2901 8434 A possible steroid mimic.
SGTC_3306 9127676 59.7925 µM -0.337668090916256 0.40188357378137 no 2043 0.367806661768519 3068 41905287
SGTC_2958 9077254 16.72 µM -0.339025107542414 0.401402208283345 no 2044 0.367295407988941 3200 16457351
SGTC_1933 st074711 15.9 µM -0.340100486304311 0.401020852522019 no 2045 0.366890427782554 2997 17250958
SGTC_1995 st072814 61.1 µM -0.340151894662046 0.401002624212499 no 2046 0.36687107145609 3008 5769371
SGTC_1179 1021-1431 9.29 µM -0.340918458789568 0.400730842474911 no 2047 0.366582484138884 3088 2840958
SGTC_1897 st060201 15 µM -0.342636862768148 0.400121765112995 no 2048 0.365935833231531 3021 611878
SGTC_276 colchicine 750 µM -0.343240954084918 0.399907706406997 no 2049 0.365708598559918 3150 2833 A microtubule depolymerizer.
SGTC_2636 apigenin dimethyl ether 100 µM -0.343417970262093 0.39984498672751 no 2050 0.365642021169899 3154 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_112 phenothiazine 287.218 µM -0.344434329311102 0.399484924419365 no 2051 0.365259837696179 3164 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_203 k066-0004 30.888 µM -0.344970900061369 0.399294869649748 no 2052 0.365058123880849 3090 6795412
SGTC_2065 5221596 34.26 µM -0.347134515474202 0.39852875396073 no 2053 0.364245132131987 3145 788581
SGTC_673 1082-0474 110 µM -0.347940554357089 0.398243443017537 no 2054 0.363942413957025 3059 3098046
SGTC_575 k072-0246 11.9 µM -0.348032737693012 0.39821081664731 no 2055 0.363907798736343 3028 6796779
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.348962168311853 0.397881903848358 no 2056 0.363558855815356 3031 689007
SGTC_2008 4012253 172 µM -0.352442370786422 0.396650954111724 no 2057 0.362253265277676 3003 603940
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.352841419711347 0.396509875808552 no 2058 0.362103664938004 3251 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_106 0092-0003 11.579 µM -0.354626864204429 0.395878822430504 no 2059 0.361434573915824 3079 1072148
SGTC_3259 9138485 49.47 µM -0.356031359536424 0.395382604590961 no 2060 0.360908540189566 3346 17646153
SGTC_2393 9031399 185.94 µM -0.356065710555791 0.39537047026128 no 2061 0.360895677795295 3168 1526623 YDL150W RPC53
SGTC_3331 9141060 1.957 µM -0.356743870476169 0.395130934368726 no 2062 0.360641779850633 3031 4906567 YPR165W RHO1
SGTC_603 3794-0023 45.9 µM -0.358501330517637 0.394510358672651 no 2063 0.359984086178019 3138 3802260
SGTC_2947 9072639 7.68 µM -0.35949130164953 0.394160908271824 no 2064 0.359613791899546 3122 16488146
SGTC_85 0868-0259 160.055 µM -0.360079586146418 0.393953289766869 no 2065 0.359393809104149 3083 83173
SGTC_871 0574-0004 149 µM -0.361023111385628 0.393620361960061 no 2066 0.359041085093349 3021 9551173
SGTC_453 enantio-paf c16 10 µM -0.361740324773731 0.393367341472449 no 2067 0.358773045023467 3155 13871343 A lipid and platelet activating factor
SGTC_1706 st031321 9.9705 µM -0.362617663281302 0.393057892848522 no 2068 0.35844525686922 3145 6103185
SGTC_745 0469-0705 296 µM -0.363223296976945 0.392844317427062 no 2069 0.35821904293644 3259 3486736
SGTC_1554 st069299 38.7 µM -0.364167885640992 0.392511274674182 no 2070 0.357866323215614 3118 24207999
SGTC_1740 st038286 13.222 µM -0.364522540351518 0.392386250944075 no 2071 0.357733922583882 3257 716786
SGTC_1637 st007924 17.4 µM -0.365095416142651 0.392184322858962 no 2072 0.357520091241742 3014 683336
SGTC_60 0986-0278 202 µM -0.367096329066401 0.391479266290498 no 2073 0.356773582710201 3031 3110598
SGTC_2003 4023581 200 µM -0.369569944635952 0.390608137495479 no 2074 0.355851474345149 3185 16641307
SGTC_1180 1193-0155 285 µM -0.369673987987033 0.390571508730239 no 2075 0.355812707750349 3183 2921347
SGTC_3126 9127922 49.47 µM -0.37336694755757 0.389272022787382 no 2076 0.354437677905522 3262 45595682
SGTC_2724 maprotiline 69.64 µM -0.373368107387454 0.389271614857762 no 2077 0.354437246353341 3197 4011 A tricyclic antidepressant.
SGTC_1252 0493-0875 34.8 µM -0.37422450455656 0.388970440428397 no 2078 0.354118647164182 3042 3960963
SGTC_1170 0310-0127 64.8 µM -0.374262404868285 0.388957113334088 no 2079 0.354104549745307 3120 774975
SGTC_2798 7813637 45.45 µM -0.375293225626378 0.388594690335245 no 2080 0.353721201880654 3191 956368
SGTC_56 0957-0365 83.25 µM -0.375791229156448 0.388419633569787 no 2081 0.353536054410938 3186 6752360
SGTC_3282 9108498 15.4605 µM -0.376016751485681 0.388340366063634 no 2082 0.353452221242408 3147 16459645
SGTC_2477 5967686 25.23 µM -0.376316143925738 0.388235141575769 no 2083 0.353340939401917 3016 776118
SGTC_2220 6782180 200 µM -0.377858811708813 0.387693085643353 no 2084 0.352767740705286 3126 833803
SGTC_615 k087-0205 167 µM -0.378765916254899 0.387374453260309 no 2085 0.352430849843941 3076 9642773
SGTC_1349 flufenamic acid 69 µM -0.379209700388519 0.387218595875826 no 2086 0.352266074360809 3061 3371 A non-steroidal anti-inflammatory.
SGTC_1329 1447-1697 50.6 µM -0.379783482175232 0.387017110149299 no 2087 0.352053072311853 3160 2840515
SGTC_683 panaxydol 45 µM -0.380993099380683 0.38659244811063 no 2088 0.351604184489272 3093 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.381491366036758 0.386417560377596 no 2089 0.351419338308186 3144 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_322 k048-0136 19.3 µM -0.382298762132528 0.386134219601666 no 2090 0.351119886380396 3171 6823282
SGTC_1459 k035-0031 35.7 µM -0.382315017050424 0.386128515860908 no 2091 0.351113858606985 3039 3877128 YMR208W ERG12
SGTC_1316 1272-0050 65.9 µM -0.384179199022088 0.385474550566 no 2092 0.350422817172449 3071 7340392
SGTC_1556 plumbagin 1.48 µM -0.385373765860065 0.385055660926551 no 2093 0.349980258138593 3146 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_853 0419-0306 21 µM -0.385556409561706 0.384991626460446 no 2094 0.34991261086392 3072 762713
SGTC_2108 5365811 200 µM -0.385601803157671 0.384975712055577 no 2095 0.349895798797293 3189 780283
SGTC_3147 9097027 49.47 µM -0.385866785669373 0.384882816497998 no 2096 0.349797665196703 3091 25236841
SGTC_2377 9073351 62.6 µM -0.386624680467999 0.384617155986068 no 2097 0.349517041910559 3072 7337946 YHR072W ERG7
SGTC_64 000l-0018 272.079 µM -0.387995340480831 0.384136844056701 no 2098 0.349009740897184 3017 6811119
SGTC_577 r071-0003 38.6 µM -0.388049466662681 0.384117880598978 no 2099 0.348989713548063 3089 4568517 YMR134W ERG29
SGTC_1141 3253-0389 52.6 µM -0.38836100968554 0.384008734881963 no 2100 0.348874447000223 3177 5402031
SGTC_1471 k673-0312 37 µM -0.38983858365429 0.383491208288962 no 2101 0.348327955433977 3132 24099884
SGTC_1235 benzylparaben 21.5 µM -0.390175667244552 0.383373172399078 no 2102 0.348203326645635 3155 7180
SGTC_585 0kpi-0023 191 µM -0.39058901402022 0.383228446357334 no 2103 0.348050523698206 3207 64601
SGTC_3247 9135149 49.47 µM -0.391666345370859 0.382851314526058 no 2104 0.347652379882695 3108 8934436 YOR116C RPO31
SGTC_294 k038-0071 157 µM -0.39369286049096 0.382142211482027 no 2105 0.346903906536188 3145 24152826
SGTC_360 0957-0399 1.01 µM -0.395422302541334 0.38153737041146 no 2106 0.346265626164899 3229 6752301 YPR165W RHO1
SGTC_1407 3909-7909 12.3 µM -0.395510393747072 0.381506569833052 no 2107 0.346233126253704 3116 4411780
SGTC_3194 9111903 49.47 µM -0.395635464749892 0.381462840772386 no 2108 0.346186985153671 3292 17087251
SGTC_1743 st037606 46.3785 µM -0.395911726721124 0.381366255588984 no 2109 0.346085074887644 3090 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_909 3448-9333 149 µM -0.396501880528014 0.38115995403229 no 2110 0.34586741042138 3072 3344074
SGTC_2766 oltipraz 83.91 µM -0.397223980091948 0.380907573807767 no 2111 0.345601150125743 3231 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1705 st027868 56.3335 µM -0.401720376469849 0.379337186997868 no 2112 0.343944913361592 3168 292948
SGTC_1470 k295-0292 231 µM -0.402142545559895 0.379189844265018 no 2113 0.343789561451374 3218 5045612
SGTC_1420 4'-methoxyflavone 42 µM -0.403247964159293 0.378804121379201 no 2114 0.343382908933966 3195 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2593 nobiletin 86.24 µM -0.405299897104753 0.378088443562046 no 2115 0.342628541062177 3167 72344 An anti-infammatory.
SGTC_1443 4112-3303 14 µM -0.40621368511891 0.377769864927578 no 2116 0.342292799815697 3131 704433
SGTC_2254 7938975 95.19 µM -0.40666544087557 0.377612397675967 no 2117 0.342126863085398 3293 2969277
SGTC_2153 5569715 200 µM -0.408069213238112 0.377123218541458 no 2118 0.341611430888892 3180 2054701
SGTC_129 0088-0017 176.636 µM -0.409374488212153 0.376668540099477 no 2119 0.341132429432604 3237 182446
SGTC_193 1273-0060 1.558 µM -0.409502595682761 0.376623924452028 no 2120 0.34108543115134 3192 2847393 YHR072W ERG7
SGTC_3315 9136395 68.55 µM -0.410415004365705 0.37630621000819 no 2121 0.340750770734697 3320 16876844
SGTC_2341 7987486 176.74 µM -0.410441933472508 0.376296834159709 no 2122 0.340740895368023 3275 1258686
SGTC_221 trifluoperazine 10.304 µM -0.411486584701387 0.375933176606666 no 2123 0.340357888096652 3167 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1927 st060202 13.8 µM -0.411658467973102 0.375873352205396 no 2124 0.340294885175856 3270 688887
SGTC_1353 1498-1206 8.11 µM -0.41182586774145 0.37581509116628 no 2125 0.340233529944778 3187 6756808
SGTC_2266 7929956 200 µM -0.412398680385084 0.375615753534932 no 2126 0.34002361511394 3147 2967153
SGTC_2396 5342950 42.78 µM -0.413116132595561 0.375366128464521 no 2127 0.339760765134117 3192 1886677
SGTC_1152 3909-8331 15.9 µM -0.413386238021805 0.375272163473629 no 2128 0.339661827910556 3156 16001939
SGTC_321 4534-3890 65.3 µM -0.413392557742216 0.375269965041139 no 2129 0.339659513185214 3226 699746
SGTC_520 3584-0023 682 µM -0.415415726051887 0.374566376862989 no 2130 0.338918798166725 3150 1340790
SGTC_1657 st012939 43.4 µM -0.415510782637338 0.374533329708941 no 2131 0.338884011681379 3259 24207257
SGTC_1178 0988-0033 191 µM -0.416809853528437 0.374081790162589 no 2132 0.33840874727591 3244 5392207
SGTC_841 0251-0215 91.2 µM -0.418053552049288 0.373649659112014 no 2133 0.337953981868593 3204 3888614
SGTC_2296 7971656 126.45 µM -0.419175927337529 0.37325981889855 no 2134 0.337543781893461 3203 666570
SGTC_376 3970-0862 59.1 µM -0.41938847116051 0.373186009585454 no 2135 0.337466124180318 3244 3135186
SGTC_1875 nocodazole 6 µM -0.420638986672188 0.372751841969743 no 2136 0.337009360200696 3272 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1753 st043925 64 µM -0.422318523732115 0.372168976331815 no 2137 0.336396269630295 3233 670181
SGTC_696 1560-0013 611 µM -0.422457106388514 0.372120895737973 no 2138 0.336345701442559 3330 1650269
SGTC_1337 1486-1011 40.3 µM -0.42248826244352 0.372110086567271 no 2139 0.336334333145851 3246 X1337
SGTC_1929 genistein trimethyl ether 50.5 µM -0.423757562801602 0.371669805798648 no 2140 0.335871315094746 3330 136420
SGTC_1714 st033236 13.627 µM -0.424352656035109 0.371463444231161 no 2141 0.335654321426392 3322 2916566
SGTC_825 1988-2224 89.6 µM -0.424785047478816 0.371313526227465 no 2142 0.335496689394767 3153 1180859
SGTC_2479 5617353 43.85 µM -0.426768583987398 0.370626048436074 no 2143 0.33477394543028 3306 2731746
SGTC_1563 conessine 56.1 µM -0.427138692898949 0.370497817308877 no 2144 0.334639155960873 3239 441082 An anti-amoebic, histamine inhibitor.
SGTC_366 0181-0206 4.31 µM -0.42716276589128 0.370489477270403 no 2145 0.334630389587837 3351 274874
SGTC_1013 4112-3890 241 µM -0.427938978977954 0.370220592493564 no 2146 0.334347773710785 3090 705171
SGTC_2813 7971799 71.43 µM -0.429484363019508 0.369685451277575 no 2147 0.333785385562857 3236 2234054
SGTC_1294 1000-1494 117 µM -0.431086514479128 0.369130918801644 no 2148 0.333202732880059 3185 712797 YDL207W GLE1
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.431154487173335 0.369107398282539 no 2149 0.333178022211093 3315 1273210
SGTC_1406 3909-7906 11.9 µM -0.431439959308767 0.369008622015141 no 2150 0.33307425010141 3214 X1406
SGTC_275 trichlorophene 5.69 µM -0.432168933910837 0.368756428636692 no 2151 0.332809318204354 3249 62616
SGTC_3232 9132874 49.47 µM -0.433310094362319 0.368361750454914 no 2152 0.33239475284577 3194 3784940
SGTC_298 1391-0729 10 µM -0.433947522194323 0.368141352078025 no 2153 0.332163274681265 3158 3237558
SGTC_996 3970-0799 1.8 µM -0.436597819589711 0.367225445734113 no 2154 0.331201522107341 3209 6615648 YGL040C HEM2
SGTC_1805 st050013 60.3 µM -0.436706974122323 0.367187739581317 no 2155 0.331161935398874 3188 4037144
SGTC_443 clozapine 122 µM -0.437156072347922 0.367032617347187 no 2156 0.330999082308058 3241 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1973 st070275 50.2 µM -0.437576314020911 0.366887482062074 no 2157 0.33084672220393 3239 17118334
SGTC_1376 2910-0861 41.3 µM -0.437597200308712 0.366880269238964 no 2158 0.330839150537045 3226 1112859
SGTC_858 0438-0351 2.77 µM -0.438078231262577 0.366714164113608 no 2159 0.3306647870463 3207 2799119
SGTC_71 0417-1750 47.813 µM -0.439696039575116 0.366155700901566 no 2160 0.330078635692786 3318 6811472
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.439932004641852 0.366074270029633 no 2161 0.329993177519948 3241 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2566 crystal violet carbinol 226 nM -0.441657470406684 0.365479000241717 no 2162 0.329368544900422 3283 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1926 methyl fluorone black 53.6 µM -0.444403529207355 0.364532303599848 no 2163 0.328375431158026 3178 72721 Reacts with homocysteine.
SGTC_1213 1315-0166 115 µM -0.445196057328443 0.36425923485894 no 2164 0.328089037867779 3240 768401
SGTC_130 0136-0219 337.655 µM -0.446338685672573 0.363865658970248 no 2165 0.327676307878101 3190 234244
SGTC_1138 3761-0006 1.03 µM -0.446510231503901 0.363806582761763 no 2166 0.327614361785283 3285 12061087
SGTC_2999 9069765 71.4286 µM -0.447159392068629 0.363583056981054 no 2167 0.327379989487402 3223 2097066
SGTC_1814 st052110 31.539 µM -0.448588051400381 0.36309128962625 no 2168 0.32686442741061 3318 674163
SGTC_3081 9117243 49.47 µM -0.450586897178709 0.362403633807465 no 2169 0.32614365598164 3336 45595589
SGTC_2411 st077133 39.94 µM -0.451773716703924 0.361995546288753 no 2170 0.32571600306437 3438 1403142 YNL221C POP1
SGTC_1895 st058434 18.3 µM -0.452668413632708 0.361688008690511 no 2171 0.325393763735043 3356 5393175
SGTC_1615 st002656 86.5 µM -0.452824495133286 0.361634367343378 no 2172 0.325337561861105 3291 1584458
SGTC_2893 9048488 25.97 µM -0.453865526301732 0.361276660300311 no 2173 0.324962808693104 3225 6467338
SGTC_2646 retinol 96.75 µM -0.454151828785053 0.361178305610296 no 2174 0.324859775787371 3287 445354 A vitamin A analog and teratogen.
SGTC_2971 9092186 9.93 µM -0.456424581088863 0.360397863534782 no 2175 0.324042346446317 3151 25236400
SGTC_284 0988-0104 32.6 µM -0.456619247152093 0.360331043994012 no 2176 0.32397237124371 3266 4666532
SGTC_2910 7948405 25.97 µM -0.45693319467116 0.360223289827697 no 2177 0.3238595319033 3318 2971328
SGTC_2028 5153890 36.43 µM -0.457266412654012 0.360108933731651 no 2178 0.32373978405991 3232 2830968 YPR165W RHO1
SGTC_3245 9134821 49.47 µM -0.458065371985166 0.35983479224119 no 2179 0.323452738067258 3215 17014901
SGTC_897 1000-0139 31.4 µM -0.459057817444275 0.359494361573909 no 2180 0.323096323658169 3336 6151020
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.459661621527714 0.359287297992767 no 2181 0.322879560448294 3521 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_719 2810-4230 27.3 µM -0.460788477562272 0.358900973854047 no 2182 0.322475184649483 3264 721079
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.461366450263053 0.358702881331249 no 2183 0.322267858764471 3327 61125 An anti-inflammatory.
SGTC_3156 9099931 49.47 µM -0.461956393528398 0.358500725246663 no 2184 0.322056295898491 3161 18111053
SGTC_870 0573-2213 57.6 µM -0.461996690597707 0.35848691808038 no 2185 0.322041846843 3319 3916321
SGTC_2066 5222451 176 µM -0.46230360962321 0.358381763104071 no 2186 0.321931805731673 3219 2281147
SGTC_1161 k007-0610 110 µM -0.46290100086619 0.358177118868424 no 2187 0.321717665035912 3346 5843850
SGTC_2437 5741531 144.16 µM -0.463627793996316 0.357928201245087 no 2188 0.32145721881798 3375 2262990
SGTC_1507 4075-3230 155 µM -0.464660739574122 0.357574534139843 no 2189 0.321087213911681 3276 659771
SGTC_14 0354-0009 295 µM -0.467989863460017 0.35643551888568 no 2190 0.319895919288924 3235 1713507
SGTC_2019 4016004 108 µM -0.471548866231435 0.355219268560347 no 2191 0.318624416101555 3271 45595336
SGTC_982 1491-0518 27.5 µM -0.472697505919654 0.354827047387884 no 2192 0.318214503113035 3219 3091256
SGTC_1560 lithocholic acid 53.1 µM -0.47284148565473 0.354777894073079 no 2193 0.318163137007524 3287 9903 A bile acid which acts as a detergent.
SGTC_2825 7998094 58.44 µM -0.473104100701895 0.354688246015525 no 2194 0.318069455660896 3248 2987815
SGTC_529 4076-0302 30.3 µM -0.473795193257951 0.354452368427587 no 2195 0.317822981311918 3237 5816522
SGTC_787 4152-0075 138 µM -0.475689539589387 0.353806093323022 no 2196 0.317147787142496 3253 9566539
SGTC_1997 st073024 93.8 µM -0.475949780546832 0.353717342384372 no 2197 0.317055077985246 3337 686268
SGTC_3010 9080089 71.4286 µM -0.476207621818565 0.353629417659772 no 2198 0.316963235024555 3313 17027233
SGTC_3350 9150499 3.57 µM -0.477825736366168 0.353077813687191 no 2199 0.316387120875001 3240 4910996 YPR165W RHO1
SGTC_132 0417-1715 25.805 µM -0.479108166171339 0.352640861433524 no 2200 0.315930840286945 3408 6769098
SGTC_1143 3454-2408 5.08 µM -0.479172525186299 0.352618938007631 no 2201 0.315907949128358 3313 X1143
SGTC_2572 astragaloside iv 100 µM -0.480997207321037 0.351997577358536 no 2202 0.315259241773018 3356 45006101 An anti-inflammatory agent.
SGTC_1642 st009582 77.7 µM -0.481158577339118 0.351942644868457 no 2203 0.315201899191899 3381 6739311
SGTC_261 5-fluorouridine 15.376 µM -0.482043733046119 0.351641381139206 no 2204 0.314887439728687 3416 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1906 st060206 94.7 µM -0.482950580742202 0.351332831114885 no 2205 0.314565413111954 3343 5133468
SGTC_2305 7443522 69.23 µM -0.483241596907785 0.351233835189303 no 2206 0.314462101542749 3291 5415886
SGTC_1383 3049-0032 20.7 µM -0.484959974147927 0.350649495105591 no 2207 0.313852369097409 3372 712864
SGTC_2514 salinomycin 42.74 µM -0.485040235906222 0.350622210441792 no 2208 0.313823902192316 3378 23682228 A polyether potassium ionophore.
SGTC_2000 st075254 36.4 µM -0.485613127955977 0.350427480466732 no 2209 0.313620743427437 3330 17234175
SGTC_1036 k216-0215 33.5 µM -0.488037630123164 0.349603811073116 no 2210 0.312761593627532 3313 622330
SGTC_608 k048-0125 159 µM -0.489177571611149 0.349216786196989 no 2211 0.312357993362356 3374 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_24 0417-1663 219 µM -0.489596377828637 0.349074635422774 no 2212 0.312209770053449 3344 4329390
SGTC_557 1315-0110 16.2 µM -0.490605078626796 0.348732350188652 no 2213 0.3118528968608 3258 6833801
SGTC_950 1165-0508 94.1 µM -0.49441716482436 0.347439898023439 no 2214 0.310505797036415 3319 6148369
SGTC_2698 st077697 67.5 µM -0.495320512516535 0.347133885542425 no 2215 0.310186946843482 3272 3154499
SGTC_3132 9126706 49.47 µM -0.495652513577958 0.347021443945498 no 2216 0.310069797895246 3422 850858
SGTC_62 0180-0423 3.232 µM -0.496740707493522 0.346652990605832 no 2217 0.309685956077716 3305 30102 YGL099W LSG1
SGTC_2286 7945697 125 µM -0.497457286163474 0.346410442233087 no 2218 0.309433308439623 3303 1245733
SGTC_681 1642-0006 26.6 µM -0.500470587237108 0.345391186729999 no 2219 0.308371880772592 3376 4446530
SGTC_2453 5731132 22.18 µM -0.501842051837551 0.344927656378788 no 2220 0.307889315071771 3395 1362040
SGTC_508 roscovitine 141 µM -0.506311055799852 0.343418830658653 no 2221 0.306319151473594 3356 160355 A CDKinase inhibitor.
SGTC_1923 st058458 19.1 µM -0.506672837763867 0.343296794498342 no 2222 0.306192196036269 3452 3534982
SGTC_938 3126-1755 342 µM -0.506860029407805 0.343233657494037 no 2223 0.30612651644234 3408 1777771
SGTC_1989 st071868 50.2 µM -0.507418254255692 0.343045402400603 no 2224 0.30593069010412 3384 16414057
SGTC_1080 nisoldipine 24.4 µM -0.510633634542961 0.341961810936153 no 2225 0.304803809737221 3248 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2372 9071633 200 µM -0.511405078330372 0.341702025485079 no 2226 0.304533719837673 3402 21321366
SGTC_2460 5552655 174.22 µM -0.5119204956715 0.341528499282777 no 2227 0.304353326622243 3389 5401989
SGTC_790 1575-0012 79.1 µM -0.513394593108378 0.341032398018219 no 2228 0.303837663496381 3417 378741 YLR208W SEC13
SGTC_89 0302-0250 142.109 µM -0.514169689475332 0.340771652752183 no 2229 0.303566678685718 3416 4203518 YLR208W SEC13
SGTC_483 fpl-64176 144 µM -0.514723412033372 0.340585425016375 no 2230 0.303373155448517 3397 3423
SGTC_721 1187-1332 279 µM -0.515755145188179 0.340238536635969 no 2231 0.303012717066377 3303 25730
SGTC_3219 9131112 49.47 µM -0.515808529490502 0.340220591489793 no 2232 0.302994072350898 3371 17612988 YMR079W SEC14
SGTC_415 dibenzyl ketone 100 µM -0.516228984471823 0.340079268097625 no 2233 0.302847244444467 3357 7593
SGTC_1289 0976-0073 69.1 µM -0.516657630472275 0.339935214664901 no 2234 0.302697588939269 3402 3391136
SGTC_2466 5983409 37.09 µM -0.516795709116991 0.339888816074546 no 2235 0.302649387848413 3321 2879657
SGTC_1389 3405-0187 19 µM -0.51751265256808 0.339647940449555 no 2236 0.302399169433414 3330 799890
SGTC_3072 9116419 49.47 µM -0.517596263357022 0.339619853512119 no 2237 0.302369994709233 3339 17170162
SGTC_2628 lathosterol 100 µM -0.522069751255501 0.338118400063314 no 2238 0.300810883259652 3444 6710616
SGTC_611 3453-1652 23.7 µM -0.524686517959569 0.337241315084484 no 2239 0.299900565544618 3427 1560575
SGTC_2716 st080858 38.6235 µM -0.525565379638041 0.336946937224542 no 2240 0.29959510814156 3419 5296050
SGTC_2619 obliquin 87.91 µM -0.527699044523597 0.336232674268227 no 2241 0.298854118260049 3382 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2771 fluoxetine 41.05 µM -0.528505285451502 0.335962931725721 no 2242 0.29857433978912 3457 3386 A selective serotonin reuptake inhibitor.
SGTC_3253 9135987 49.47 µM -0.529273421718035 0.335706016356091 no 2243 0.298307895114345 3407 4182430
SGTC_2657 nystatin 74.44 µM -0.530244358782134 0.335381380903423 no 2244 0.297971259578779 3410 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_961 1252-1571 372 µM -0.531452946337842 0.334977458049215 no 2245 0.297552469862057 3461 6813498
SGTC_2148 5546263 113.568 µM -0.531460929411566 0.334974790654634 no 2246 0.29754970452717 3300 792097
SGTC_1272 0839-0021 27 µM -0.532409232416295 0.334657992222856 no 2247 0.297221296095844 3382 5027250
SGTC_1047 2043-3044 82 µM -0.533130086058869 0.334417256224173 no 2248 0.29697176692619 3333 669592
SGTC_401 neomycin 50 µM -0.535054645042515 0.333774864977212 no 2249 0.296306035616596 3377 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2986 9022445 71.43 µM -0.53576711937439 0.333537174261921 no 2250 0.296059754673015 3423 6459286
SGTC_1474 0330-0125 5.35 µM -0.536182324798907 0.33339868712996 no 2251 0.295916273990874 3431 X1474
SGTC_645 0845-0943 5.41 µM -0.536808319805962 0.333189936412364 no 2252 0.29570001207754 3361 1885106
SGTC_3075 9116269 49.47 µM -0.536999404900702 0.333126225506043 no 2253 0.295634012559601 3471 17015205 YNL244C SUI1
SGTC_843 0310-0051 143 µM -0.539396321165245 0.332327463870764 no 2254 0.294806709464623 3381 2065037
SGTC_382 3229-0966 23.2 µM -0.539647568101641 0.332243780954277 no 2255 0.294720052640645 3474 5722370
SGTC_1717 st033143 58.0435 µM -0.540093776407102 0.33209518279591 no 2256 0.294566181241183 3482 674616
SGTC_1268 0828-0275 2.46 µM -0.541308997834403 0.33169061857773 no 2257 0.29414730981583 3426 745337
SGTC_1494 4358-1428 177 µM -0.541342271786303 0.331679543971485 no 2258 0.294135844578563 3469 1564571
SGTC_2658 polymyxin b sulfate 77.05 µM -0.54225615477618 0.331375432820855 no 2259 0.293821027807038 3394 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2970 9090938 41.86 µM -0.542426188974168 0.331318863114137 no 2260 0.293762471191451 3471 17217104
SGTC_2352 9027995 87.8 µM -0.543960235206912 0.330808666118567 no 2261 0.293234418493738 3371 2997347
SGTC_485 niflumic acid 177 µM -0.544586577455782 0.330600445875658 no 2262 0.293018944196945 3443 4488 A COX2 inhibitor.
SGTC_905 2-aminofluorene 215 µM -0.544901147513604 0.330495890464571 no 2263 0.292910753504955 3467 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2534 helenine 20.12 µM -0.545493717741644 0.330298970515929 no 2264 0.292707000045568 3408 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3195 9113082 49.47 µM -0.547074034410293 0.329774037530158 no 2265 0.292163935117152 3436 17018038
SGTC_2152 5568786 200 µM -0.5492410114894 0.329054778784731 no 2266 0.29142003154495 3406 5399883
SGTC_470 aa-861 153 µM -0.549770616731936 0.328879089326705 no 2267 0.291238357332348 3389 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_184 1494-0393 24.714 µM -0.550024248078091 0.328794963903697 no 2268 0.291151371114421 3346 3090647
SGTC_2315 7733312 200 µM -0.551764921613979 0.32821784481788 no 2269 0.290554711754616 3350 726316
SGTC_307 1501-1223 22.3 µM -0.552225289849504 0.328065278515109 no 2270 0.290397004760534 3431 2830329
SGTC_955 1216-0110 33 µM -0.555107477559975 0.327110772545824 no 2271 0.289410574231814 3421 3619719
SGTC_3224 9130643 49.47 µM -0.556236577423005 0.32673715151242 no 2272 0.28902456868402 3516 17644395
SGTC_346 4513-0042 7.16 µM -0.557644090771122 0.326271646202072 no 2273 0.288543721273699 3433 2827372
SGTC_2303 7774051 200 µM -0.558237932472485 0.326075326700304 no 2274 0.288340960838845 3486 2953184
SGTC_318 1488-0629 67.2 µM -0.55856775270788 0.325966311479583 no 2275 0.288228376529072 3450 3662576
SGTC_383 2324-0395 7.37 µM -0.558626200093303 0.325946994462928 no 2276 0.288208427646492 3477 3146421
SGTC_2846 9008642 19.48 µM -0.560427144071256 0.325352006858286 no 2277 0.287594060588288 3457 2992898
SGTC_1126 isoteolin 1.0172 µM -0.560493330039163 0.325330149108367 no 2278 0.287571493961969 3427 133323
SGTC_979 1426-2828 121 µM -0.560850683329212 0.325212144462153 no 2279 0.287449666010686 3497 747872
SGTC_1559 coumarin 343 70.1 µM -0.562310122693415 0.324730392726745 no 2280 0.28695237132698 3501 108770 A hepatotoxic, DNA x-linker.
SGTC_672 1441-0018 53.7 µM -0.5628222469408 0.324561413153425 no 2281 0.286777964898831 3381 251141
SGTC_1472 k841-0093 193 µM -0.563931091226364 0.32419566470468 no 2282 0.286400514802835 3515 X1472
SGTC_446 go6976 132 µM -0.566254329163981 0.323429902924679 no 2283 0.285610451096964 3453 3501 A protein kinase C inhibitor.
SGTC_2764 methyldopa 94.69 µM -0.567286927678866 0.32308978811121 no 2284 0.285259628491477 3524 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_711 k292-0785 179 µM -0.568854716117466 0.322573676448033 no 2285 0.284727369373022 3483 4146315
SGTC_655 k060-0012 42 µM -0.570799840052975 0.321933821956003 no 2286 0.284067665688745 3402 5994525
SGTC_1212 0520-0165 585 µM -0.571607666270917 0.321668239979454 no 2287 0.283793900286557 3653 5403258
SGTC_70 0141-0289 43.283 µM -0.571780379802791 0.321611470275371 no 2288 0.283735385541493 3411 352408
SGTC_458 nppb 133 µM -0.572010923603294 0.321535698666138 no 2289 0.283657287106718 3547 4549 A chloride channel blocker.
SGTC_2084 5306078 60.6385 µM -0.573384266930909 0.32108448312435 no 2290 0.28319227028661 3370 679340
SGTC_191 3914-0123 66.505 µM -0.574080033302801 0.320855987988878 no 2291 0.282956822048252 3357 3144412
SGTC_1332 1480-0653 17.5 µM -0.574451515337088 0.320734018148458 no 2292 0.28283115054616 3464 5749438
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.574572026013011 0.320694454663207 no 2293 0.282790387826701 3480 3256 An antibiotic and ribosome inhibitor.
SGTC_597 k018-0003 82.8 µM -0.574634427231135 0.320673969231465 no 2294 0.282769281732381 3510 6786234
SGTC_1308 1187-1617 41.4 µM -0.574969762385927 0.320563892827494 no 2295 0.282655873585203 3475 2882570
SGTC_686 1319-0111 510 µM -0.575315100538734 0.320450549353445 no 2296 0.282539105341737 3543 4562600
SGTC_280 3448-3607 3.04 µM -0.576799550574067 0.319963528631334 no 2297 0.282037436602262 3488 626179
SGTC_556 4058-0063 51.5 µM -0.577859004505725 0.319616130895534 no 2298 0.281679657492614 3473 6615692
SGTC_2383 9036125 200 µM -0.580468355372962 0.318761193068136 no 2299 0.280799410313233 3435 79580
SGTC_2640 pentamidine 10.38 µM -0.580478465959344 0.318757882267868 no 2300 0.280796002162599 3486 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_134 0269-0018 6.916 µM -0.58082166673459 0.318645506742224 no 2301 0.280680325392126 3425 4378915
SGTC_39 0986-0283 58.349 µM -0.58161951308123 0.318384329363406 no 2302 0.280411498192395 3551 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_506 n9-isopropylolomoucine 153 µM -0.582153605675671 0.318209542975564 no 2303 0.28023161014532 3504 6610355
SGTC_2662 daunorubicin 22.37 µM -0.582258608822661 0.31817518455325 no 2304 0.280196250549337 3415 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2239 6685329 187.64 µM -0.58283654357136 0.317986104647193 no 2305 0.280001670899666 3497 805680
SGTC_328 k915-0120 63.5 µM -0.582904500829108 0.31796387454056 no 2306 0.279978795287118 3489 6624543
SGTC_3240 9133527 49.47 µM -0.583730219772541 0.317693818652611 no 2307 0.279700916130692 3464 17617455
SGTC_2165 5727197 32.143 µM -0.584260724400223 0.317520365368205 no 2308 0.279522456077484 3649 1361712
SGTC_352 k048-0007 5.11 µM -0.584439244522937 0.317462005605537 no 2309 0.279462414916651 3480 6811911
SGTC_569 4130-2812 160 µM -0.586256469186241 0.316868197598576 no 2310 0.278851589597137 3434 743552
SGTC_1677 st019204 53.9 µM -0.586937814437649 0.316645678280992 no 2311 0.278622735995375 3451 3945625
SGTC_2757 clomiphene 4.22 µM -0.587899416640045 0.316331743238859 no 2312 0.278299904022276 3581 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2876 9059903 25.97 µM -0.5888487040669 0.316021958394432 no 2313 0.277981385365294 3494 6916095
SGTC_694 1315-0438 43.2 µM -0.58911659247392 0.315934560629927 no 2314 0.277891531764599 3419 6793154
SGTC_628 1636-0253 16 µM -0.589748884483385 0.315728318119961 no 2315 0.277679508224425 3466 4456143
SGTC_1218 1348-1416 30.7 µM -0.594037435276458 0.31433098513507 no 2316 0.276243537507957 3501 6787668
SGTC_758 0868-0029 16 µM -0.594049404980591 0.31432708877029 no 2317 0.276239534698511 3521 762687
SGTC_208 k072-0098 12.366 µM -0.595535561422846 0.313843477630006 no 2318 0.27574276782163 3515 5948901
SGTC_495 decylubiquinone 155 µM -0.595669101762636 0.313800037819443 no 2319 0.275698151756427 3477 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1478 0453-0656 35.7 µM -0.596026524484133 0.313683783215166 no 2320 0.27557875365137 3537 5258496
SGTC_1340 1486-1359 257 µM -0.596853539751908 0.313414860809194 no 2321 0.275302584305661 3425 4309068
SGTC_2098 5376439 882.5 nM -0.597264582768733 0.313281237912712 no 2322 0.275165373348639 3519 2844116
SGTC_1877 wortmannin 25 µM -0.598121771696508 0.313002659649064 no 2323 0.274879342053944 3539 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1512 0259-0544 12.2 µM -0.598281261766227 0.312950838662028 no 2324 0.274826138744593 3505 18476
SGTC_2875 9039966 71.43 µM -0.600114518840669 0.312355448395156 no 2325 0.27421495856595 3482 6463691
SGTC_2334 9017922 200 µM -0.600550341838929 0.312213977332278 no 2326 0.274069760592999 3491 3163164
SGTC_1333 1482-0047 286 µM -0.600738895492997 0.312152780132096 no 2327 0.274006954186019 3532 3811116
SGTC_2589 lobaric acid 100 µM -0.601368748682388 0.311948391807494 no 2328 0.273797204391179 3452 73157 A novel microtubule depolymerizer.
SGTC_2343 7990716 14.84 µM -0.601476543418438 0.311913418050329 no 2329 0.273761315217059 3488 6456862
SGTC_3308 9128332 17.569 µM -0.602976566512354 0.311426915065973 no 2330 0.273262139197476 3546 17332805 YDL196W YDL196W
SGTC_2531 methyl deoxycholate 70.07 µM -0.604765561412841 0.310847120084566 no 2331 0.272667389593006 3456 16667744 Haematoxylin.
SGTC_2861 9024595 19.48 µM -0.605885000005677 0.310484560071409 no 2332 0.272295560371012 3456 16482810
SGTC_773 4358-1457 44.6 µM -0.605932562660648 0.310469159711819 no 2333 0.272279767689537 3553 1186886
SGTC_1427 4048-4900 550 nM -0.607116335331673 0.310085971864164 no 2334 0.271886855059212 3538 24132586
SGTC_47 0149-0135 24.25 µM -0.607953781521027 0.309815014560675 no 2335 0.271609064058523 3442 5239155
SGTC_2404 5161160 200 µM -0.608308098935804 0.309700405575922 no 2336 0.271491575258915 3524 2831543
SGTC_2722 naftopidil 47.16 µM -0.611909137715469 0.3085366495252 no 2337 0.270298937786157 3513 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1691 st019933 84.6 µM -0.612001796009867 0.308506730229202 no 2338 0.270268284643446 3517 6176082
SGTC_2985 9022375 71.43 µM -0.61324441450757 0.308105612550459 no 2339 0.269857370615091 3590 4939335
SGTC_2687 chenodiol 100 µM -0.613317224186395 0.30808211666163 no 2340 0.269833303324488 3539 5702181 A cholesterol synthesis inhibitor.
SGTC_2888 9058547 12.99 µM -0.613654986521487 0.307973130091713 no 2341 0.269721669804782 3473 16476514
SGTC_158 k038-0087 26.446 µM -0.615611779961939 0.307342060418524 no 2342 0.26907538732567 3494 X158
SGTC_1081 sertraline 6 µM -0.616571275282262 0.30703282945666 no 2343 0.268758772967985 3549 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_244 nsc-207895 1.295 µM -0.616813795682351 0.306954690481124 no 2344 0.26867877570235 3428 42640
SGTC_2810 7959871 45.46 µM -0.618186254856744 0.306512655643727 no 2345 0.268226284778503 3511 2974535
SGTC_1396 3511-0007 98.6 µM -0.622874488935461 0.305004817512166 no 2346 0.266683501799284 3515 X1396
SGTC_741 4582-0002 126 µM -0.623625791235789 0.304763488909372 no 2347 0.266436684302274 3528 2912688
SGTC_1604 st002052 72.4 µM -0.624245703024937 0.304564428678677 no 2348 0.266233118207724 3592 6254834 YHR062C RPP1
SGTC_1233 0325-0408 14.2 µM -0.626316784136379 0.303899802482434 no 2349 0.265553589781232 3563 12874
SGTC_2387 9077560 195.08 µM -0.62696563296994 0.303691714939793 no 2350 0.265340881507193 3511 5303272
SGTC_2300 7976697 71.57 µM -0.627272897109516 0.303593196708116 no 2351 0.265240183103723 3473 2236109
SGTC_531 3788-1495 174 µM -0.628624636135224 0.303159957630904 no 2352 0.264797413831761 3536 2896655
SGTC_1854 st056233 32.9 µM -0.630124022357578 0.302679720610418 no 2353 0.264306721897709 3534 5393174
SGTC_780 0109-0199 192 µM -0.631103352341862 0.302366236045398 no 2354 0.263986474671399 3616 610414
SGTC_3238 9133470 49.47 µM -0.631967295252985 0.302089807970571 no 2355 0.263704124030207 3592 3534688
SGTC_894 0960-0238 55.9 µM -0.632340296151938 0.301970497294297 no 2356 0.263582268875571 3556 6741907 YDL195W SEC31
SGTC_2250 alverine citrate 130 µM -0.633296065527298 0.301664874870807 no 2357 0.263270161068453 3510 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2478 5763493 32.33 µM -0.63510181171945 0.301087838890656 no 2358 0.262681007765235 3554 1365576 YLR208W SEC13
SGTC_1729 st035615 45.989 µM -0.635960026184227 0.300813766308612 no 2359 0.26240123836277 3500 17385451
SGTC_438 sphingosine 6.67 µM -0.636883703713296 0.300518913777322 no 2360 0.26210029921821 3414 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1600 coumarin 106 71.1 µM -0.638190246040957 0.300102067762372 no 2361 0.261674922909424 3620 100336 A hepatotoxic, DNA x-linker.
SGTC_249 wiskostatin 11.211 µM -0.638553305813156 0.299986281745837 no 2362 0.261556782989531 3584 2775510 A n-wasp and actin depolymerizer.
SGTC_1426 4048-4480 71.7 µM -0.639973380527384 0.299533589742069 no 2363 0.261094952752607 3583 14224343
SGTC_7 0192-1582 4.227 µM -0.640301185879032 0.299429135818223 no 2364 0.260988404965939 3619 252616
SGTC_1550 gossypolone 36.6 µM -0.643100146540905 0.298537931071292 no 2365 0.260079559716226 3598 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_178 4092-0806 87.505 µM -0.643567464510071 0.298389252035262 no 2366 0.259927976891878 3582 2169044
SGTC_896 0964-0007 44.5 µM -0.643965624425467 0.298262602499003 no 2367 0.259798862663596 3576 6756758
SGTC_3234 9132280 49.47 µM -0.644307810486088 0.298153777085855 no 2368 0.259687925934064 3598 17612295
SGTC_3201 9113999 49.47 µM -0.644966628128379 0.29794430430066 no 2369 0.259474406114222 3573 16649224
SGTC_180 1486-1293 102.781 µM -0.645325824471796 0.297830125155308 no 2370 0.259358030409222 3628 4140536
SGTC_1283 0922-0125 16.4 µM -0.646129993544775 0.29757457316535 no 2371 0.259097586186589 3571 3360884
SGTC_2429 5902844 64.44 µM -0.646178804609154 0.297559065017191 no 2372 0.259081782223622 3583 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2256 7954252 200 µM -0.646686385157174 0.29739781947023 no 2373 0.258917468208354 3544 2972920
SGTC_3165 9101544 49.47 µM -0.647271923464334 0.297211858300866 no 2374 0.258727984688791 3588 5002184
SGTC_1766 st045414 44.774 µM -0.648104384495647 0.296947568452463 no 2375 0.258458719186782 3630 253960
SGTC_1500 4488-1866 171 µM -0.648216441902201 0.296912000663147 no 2376 0.258422484501959 3653 2900003
SGTC_3187 9109394 49.47 µM -0.649150543422509 0.296615586316854 no 2377 0.258120537523075 3549 17098090
SGTC_46 0329-0187a 2.197 µM -0.649247979179327 0.296584675262953 no 2378 0.258089052093599 3572 46494817
SGTC_1011 4112-3381 17.4 µM -0.650094403055323 0.29631621322285 no 2379 0.257815622163804 3651 2877139
SGTC_2346 9031566 143.75 µM -0.650369919689584 0.296228851077457 no 2380 0.257726651336015 3545 4771086
SGTC_2645 abamectin 100 µM -0.650400723183103 0.296219084491236 no 2381 0.257716705151189 3588 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1191 1487-1166 10.6 µM -0.650474668715468 0.296195639850253 no 2382 0.257692829584027 3644 3955771
SGTC_2768 sulfasalazine 50.2 µM -0.651316952290691 0.295928651541415 no 2383 0.257420953737117 3639 5384001 An antioxidant and salicylic acid derivative.
SGTC_3114 9122766 49.47 µM -0.651427122093322 0.295893737926295 no 2384 0.257385403688033 3547 17176985
SGTC_1624 st003710 6.25 µM -0.653934357928991 0.295099688492334 no 2385 0.256577048616581 3606 24207033
SGTC_805 3852-0218 479 µM -0.656005361349555 0.294444536255393 no 2386 0.255910337316153 3569 6615355
SGTC_1343 1487-0095 224 µM -0.656157455139913 0.294396448572731 no 2387 0.255861409922771 3601 4560101 YGL055W OLE1
SGTC_1742 st038235 28.8875 µM -0.65685147001207 0.294177067062853 no 2388 0.255638212699345 3584 564103 YBR002C RER2
SGTC_1044 1222-0021 1.78 µM -0.659639911881259 0.29329638926233 no 2389 0.25474246764282 3570 4306703
SGTC_381 3461-2219 42.7 µM -0.661745182443704 0.292632289127981 no 2390 0.254067271444456 3599 2883159
SGTC_1090 efavirenz 20.7 µM -0.662848324364158 0.292284586067879 no 2391 0.253713850217795 3632 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1119 parthenolide 318.541 nM -0.663939017346396 0.29194099587033 no 2392 0.253364671319123 3674 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.66433855212567 0.291815181475855 no 2393 0.25323682586832 3647 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_380 3970-0968 6 µM -0.664637039314654 0.291721203681928 no 2394 0.253141336352132 3584 2891601
SGTC_927 2425-1185 123 µM -0.665926525676834 0.291315374954199 no 2395 0.252729032430061 3602 730375
SGTC_1418 3966-3099 2.4 µM -0.668304583060523 0.29056764164157 no 2396 0.251969594220023 3624 740335
SGTC_3108 9121785 49.47 µM -0.66842088779581 0.290531094953632 no 2397 0.25193248294367 3584 17140271
SGTC_1287 0971-0001 34.6 µM -0.668563513609739 0.290486280273028 no 2398 0.251886976903412 3625 4665869
SGTC_2330 7979373 200 µM -0.67000292780429 0.290034180883543 no 2399 0.251427961896264 3594 1863007
SGTC_919 tnp00227 403.569 nM -0.671825835907717 0.289462105372269 no 2400 0.25084728952051 3637 1269246 A methoxyflavone. YNL221C POP1
SGTC_1658 st012944 20 µM -0.673546662188635 0.288922552566567 no 2401 0.250299786567802 3581 24207260
SGTC_2026 5148700 152 µM -0.673664361634741 0.288885666043049 no 2402 0.250262362142211 3623 79838
SGTC_269 exalamide 29 µM -0.676675262852488 0.28794281635596 no 2403 0.249306007466074 3608 3316 A derivative of salicylamide.
SGTC_2367 9070478 135.38 µM -0.676972674939835 0.287849762047588 no 2404 0.249211645810568 3613 572802
SGTC_3162 9099653 49.47 µM -0.682877775278102 0.286005121175205 no 2405 0.247342039328591 3622 25237511
SGTC_1781 st038725 66.3 µM -0.683037727685054 0.285955233337004 no 2406 0.247291501500069 3664 4270275 YIL048W NEO1
SGTC_177 1327-0068 8.361 µM -0.684747065386195 0.285422363448463 no 2407 0.246751771906132 3663 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2129 girgensonine 121.053 µM -0.684926510553567 0.285366450548477 no 2408 0.246695148046762 3696 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1938 st074717 56.4 µM -0.68601086830287 0.28502868910942 no 2409 0.246353127459025 3564 17250979
SGTC_1917 st066507 28.5 µM -0.686139136312069 0.284988748128332 no 2410 0.246312686872047 3625 3156428
SGTC_1359 1582-0056 520 nM -0.687999427139627 0.284409778158621 no 2411 0.245726571057901 3690 3661189
SGTC_3142 9086498 49.47 µM -0.689600463577911 0.283911945177656 no 2412 0.245222737888218 3619 25236367
SGTC_665 3914-0008 307 µM -0.690335447862846 0.283683545841235 no 2413 0.244991630454604 3645 1069549
SGTC_2010 4012422 159 µM -0.691225352584524 0.283407122193313 no 2414 0.244711966961079 3643 952393
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.692903486694893 0.282886209070972 no 2415 0.244185060714877 3632 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.693452883163944 0.28271576972492 no 2416 0.244012692355868 3683 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1617 st002906 78 µM -0.695635818196062 0.282039045432146 no 2417 0.243328464467834 3683 5150859
SGTC_540 1187-0821 17.3 µM -0.696361600386287 0.281814221076053 no 2418 0.243101202292111 3663 847520
SGTC_1548 st061468 90.8 µM -0.696898506220168 0.28164796023711 no 2419 0.2429331563397 3667 390799
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.69808760525791 0.281279906582086 no 2420 0.242561204514643 3673 551469
SGTC_1285 0929-0069 65.5 µM -0.698483794902103 0.281157328315563 no 2421 0.242437344377832 3685 1206237
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.699657353334357 0.280794389127718 no 2422 0.242070657822357 3627 140250 A respiratory chain inhibitor.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.700787405308751 0.28044511915758 no 2423 0.241717849591092 3718 4213774
SGTC_2507 purpurin 79.67 µM -0.702508835526757 0.279913473945703 no 2424 0.241180946772027 3674 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1988 st071872 53.4 µM -0.704626186173486 0.279260223999415 no 2425 0.240521448967927 3686 16414116
SGTC_698 k064-0052 127 µM -0.70799853149226 0.278221312382018 no 2426 0.239473084712155 3743 5088751
SGTC_2689 tacrolimus 100 µM -0.710424134053733 0.277475228987618 no 2427 0.238720580767144 3700 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_329 k048-0121 21.3 µM -0.712796591413937 0.276746439636144 no 2428 0.237985817578731 3689 6832902
SGTC_105 0111-0055 734.78 µM -0.714263351247979 0.276296338886762 no 2429 0.237532174841784 3690 5179370
SGTC_513 4245-1575 41.7 µM -0.714275677309682 0.276292557942805 no 2430 0.237528364622068 3678 719745
SGTC_1611 st001856 99.4 µM -0.714290360931595 0.276288053864823 no 2431 0.23752382567951 3681 647478
SGTC_2638 epoxomicin 18 µM -0.715644402091373 0.27587286798549 no 2432 0.237105474549937 3708 9915668 A protesome inhibitor.
SGTC_2048 5246248 200 µM -0.717066104295714 0.275437265525726 no 2433 0.236666654609911 3685 677046
SGTC_636 0kpi-0074 126 µM -0.717612096152443 0.275270066322259 no 2434 0.236498248593238 3721 616434
SGTC_3055 9094636 49.47 µM -0.717636909807262 0.275262468818415 no 2435 0.236490596623458 3714 25236176
SGTC_1870 st057514 26.5 µM -0.719331901694431 0.274743736650543 no 2436 0.235968222145345 3706 5393161
SGTC_3179 9107801 49.47 µM -0.719630682777703 0.274652348236244 no 2437 0.235876207666601 3714 4818259
SGTC_1645 Cervolide 78 µM -0.719868996233736 0.274579465854337 no 2438 0.235802829355769 3663 23173 A fragrance.
SGTC_2761 levamisole 97.89 µM -0.720684687450426 0.274330078746103 no 2439 0.235551767847635 3707 26879 An alkaline phosphatase inhibitor.
SGTC_2096 5468907 200 µM -0.720771442528061 0.274303561076569 no 2440 0.235525074191379 3743 759785
SGTC_3209 9113616 49.47 µM -0.720977206920138 0.274240671926662 no 2441 0.235461769252063 3712 16649353
SGTC_2879 9041815 71.43 µM -0.722150499180842 0.273882206866822 no 2442 0.235100976674246 3662 4942971
SGTC_2767 sibutramine 71.45 µM -0.723480189140289 0.273476239301568 no 2443 0.234692460502522 3745 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2665 lovastatin 100 µM -0.724098151997509 0.273287670538567 no 2444 0.23450273952915 3730 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_900 1112-0045 141 µM -0.72418317625956 0.273261730784136 no 2445 0.234476642844859 3641 56211 YIL048W NEO1
SGTC_1774 st048371 48.465 µM -0.72455907232078 0.273147064588331 no 2446 0.23436128749379 3701 4242727
SGTC_1778 st046819 58.9 µM -0.725553153525421 0.272843937443006 no 2447 0.234056374288907 3762 671715
SGTC_924 2046-0044 21.3 µM -0.725791656455225 0.272771235100105 no 2448 0.233983251297259 3718 3623589
SGTC_2957 9076800 11.52 µM -0.726448984574153 0.272570912921772 no 2449 0.23378178554315 3677 16459615
SGTC_3182 9108849 49.47 µM -0.726553567206973 0.27253904787181 no 2450 0.233749740679235 3746 17133045
SGTC_1635 st007035 42.4 µM -0.726596309343795 0.272526025397554 no 2451 0.233736644884831 3718 3716403
SGTC_265 mycophenolic acid 32.932 µM -0.727048382675891 0.272388308727205 no 2452 0.233598158708983 3798 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_187 1488-2104 32.728 µM -0.727523035962803 0.27224375065745 no 2453 0.233452804464832 3761 2852859
SGTC_1214 0358-0031 63.7 µM -0.728215422107367 0.272032949330707 no 2454 0.233240863352837 3789 4301366
SGTC_670 4204-0025 119 µM -0.728506168070657 0.271944454093485 no 2455 0.233151897141589 3750 719039
SGTC_236 1509-0011 5.31 µM -0.729888944833119 0.271523770204857 no 2456 0.232729035179712 3788 3107280
SGTC_2236 dapsone 200 µM -0.73500890677991 0.269968945248518 no 2457 0.231167034865129 3743 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2920 7982904 15.77 µM -0.735623231119899 0.269782687673159 no 2458 0.230980010364319 3732 6456808
SGTC_108 0509-0257 621.132 µM -0.736590432961962 0.26948957130215 no 2459 0.230685727326269 3716 536624
SGTC_1211 1056-0033 32.3 µM -0.736906018545572 0.269393965730195 no 2460 0.230589751879164 3733 6741922
SGTC_1693 xanthone 101.9 µM -0.737225075055984 0.269297325942001 no 2461 0.230492743545348 3794 7020 An insecticide.
SGTC_948 3448-0295 75.3 µM -0.738588594246671 0.268884522370264 no 2462 0.230078426098443 3747 678569
SGTC_2154 5570129 200 µM -0.73900743494279 0.268757782743968 no 2463 0.229951241335223 3749 673366
SGTC_1591 genipin 88.4 µM -0.739103177421277 0.268728815642909 no 2464 0.229922173792971 3747 442424 A DNA cross-linking agent.
SGTC_842 0271-0008 11.1 µM -0.739164640028882 0.268710220820147 no 2465 0.229903514748577 3792 1221709
SGTC_2262 9014885 67.46 µM -0.739535378172942 0.268598071862959 no 2466 0.229790982678489 3668 6457424
SGTC_235 0330-0087 5 mM -0.740544522766821 0.268292923013427 no 2467 0.229484828080155 3766 46494818 YHR062C RPP1
SGTC_1803 st050068 52.4 µM -0.743901938899998 0.267278952060297 no 2468 0.22846790115228 3819 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2015 5119600 184 µM -0.746406161688004 0.266523914531831 no 2469 0.227711049116995 3742 2828786
SGTC_911 3456-4043 236 µM -0.747916784642828 0.266068975257034 no 2470 0.227255176378235 3837 914281
SGTC_413 propylparaben 100 µM -0.749653910836284 0.265546308865201 no 2471 0.226731586304097 3715 7175 A pharmaceutical preservative.
SGTC_3197 9113331 49.47 µM -0.750200786993329 0.265381872665633 no 2472 0.226566892450145 3757 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1795 st049545 62.3 µM -0.753727339485989 0.264322741888621 no 2473 0.225506480963049 3704 5291882
SGTC_521 r062-0005 13.8 µM -0.754070492546543 0.264219797616098 no 2474 0.225403447248004 3681 2832033
SGTC_1084 voriconazole 435 nM -0.754867068298132 0.263980907449763 no 2475 0.225164373489934 3757 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1273 0849-0096 14.1 µM -0.754892990630623 0.263973135286444 no 2476 0.22515659591649 3786 5286025
SGTC_169 k015-0017 16.025 µM -0.75571177871223 0.263727702184407 no 2477 0.224911010232064 3771 1840002
SGTC_2606 farnesol 9.78 µM -0.756117186686891 0.26360622355755 no 2478 0.224789469188093 3783 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1202 1988-0068 29.6 µM -0.759817722574699 0.262498696284862 no 2479 0.223681773903511 3733 2850480
SGTC_820 1582-0060 59.9 µM -0.760097158476246 0.262415161204714 no 2480 0.223598255522171 3784 3848840
SGTC_2167 5876490 200 µM -0.760251948444948 0.262368893866932 no 2481 0.223551999209357 3926 686534
SGTC_3271 9137798 49.47 µM -0.761134836067199 0.262105075132176 no 2482 0.223288267546151 3683 6498326
SGTC_319 1348-1596 45.5 µM -0.76148208646051 0.262001349293268 no 2483 0.223184587228914 3827 5380505
SGTC_1026 k007-1105 30.6 µM -0.761603594907319 0.261965058939854 no 2484 0.223148314307409 3765 7066794
SGTC_1318 1280-3875 124 µM -0.762401187783403 0.261726909643634 no 2485 0.222910298778183 3786 373245
SGTC_1944 st076371 56.9 µM -0.763441896446507 0.26141633672381 no 2486 0.222599950863022 3789 24208455
SGTC_2284 7945075 39.21 µM -0.763944921484107 0.261266289624427 no 2487 0.222450032995189 3852 1245402
SGTC_2913 7966556 36.57 µM -0.764614413757974 0.261066655749589 no 2488 0.222250591810601 3675 2976516
SGTC_1521 st012942 49.4 µM -0.767079923776068 0.260332149504222 no 2489 0.221516998803874 3830 24207259
SGTC_610 4215-0184 155 µM -0.769508388072105 0.259609721811779 no 2490 0.220795783457018 3819 5605015
SGTC_389 tpck 16.7 µM -0.769594836713979 0.259584023871283 no 2491 0.220770134391814 3809 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2439 5492030 7.2 µM -0.771424135151424 0.259040550123288 no 2492 0.220227786977995 3792 5722370
SGTC_709 3807-1509 243 µM -0.772171983321819 0.258818538422229 no 2493 0.220006286374987 3847 1886677 YPL242C IQG1
SGTC_2386 9075165 157.42 µM -0.773448679559145 0.258439756648863 no 2494 0.219628444990088 3758 16452277
SGTC_386 1509-0011 3.07 µM -0.775270043023946 0.257899875584708 no 2495 0.219090053561891 3834 3107280
SGTC_2157 5649910 96.377 µM -0.775755498192473 0.257756077792788 no 2496 0.218946682174697 3760 2858091
SGTC_1030 k029-0042 36.7 µM -0.777231942056796 0.25731899286218 no 2497 0.218510970005448 3802 6080581
SGTC_2950 9072895 21.46 µM -0.778014820669466 0.257087386656728 no 2498 0.218280138033764 3741 17332245
SGTC_2811 7967822 32.47 µM -0.781880832629424 0.255945260246549 no 2499 0.217142305244398 3874 2232244
SGTC_395 anisomycin 6.25 µM -0.782113921655568 0.255876484050476 no 2500 0.217073812899615 3811 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_41 0478-0632 82.643 µM -0.78343900528932 0.255485682829982 no 2501 0.216684679272595 3757 3750424
SGTC_2975 9084847 53.72 µM -0.783949164486024 0.255335306956727 no 2502 0.216534969872749 3887 27211724
SGTC_2125 5246583 200 µM -0.784640405273169 0.255131628829298 no 2503 0.216332216459167 3796 835267
SGTC_1118 chelidonine 707.474 nM -0.78481023730829 0.255081599836505 no 2504 0.216282418476659 3784 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_993 3909-8757 62.7 µM -0.785043354000523 0.255012936854051 no 2505 0.216214075036664 3789 4288324 YLR208W SEC13
SGTC_1575 cyproterone acetate 48 µM -0.785546140630406 0.254864877297338 no 2506 0.216066714321199 3826 9880 An androgen receptor antagonist and liver toxin.
SGTC_2009 4012297 12.05 µM -0.787207564327782 0.254375944884597 no 2507 0.215580184932295 3827 45595307
SGTC_1182 1222-0449 220 µM -0.788783182751142 0.253912718286127 no 2508 0.215119370146004 3814 658318
SGTC_2233 sulbentine 40.3845 µM -0.789833734320443 0.253604105780333 no 2509 0.214812437558922 3786 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2755 lomerizine 42.69 µM -0.791401564507266 0.253143902987151 no 2510 0.214354848655416 3823 3949 A calcium channel blocker.
SGTC_1982 st072467 71.9 µM -0.792348090959647 0.252866283309947 no 2511 0.214078868903802 3809 3163533
SGTC_1185 1319-0113 81.3 µM -0.792887785082888 0.252708060816554 no 2512 0.213921602311558 3869 4672763
SGTC_2151 5563267 85.4165 µM -0.793047293870943 0.252661307500211 no 2513 0.213875134412782 3849 5310824
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.793442271108282 0.252545556086508 no 2514 0.213760095440753 3849 6728940
SGTC_202 3594-0513 34.79 µM -0.794720626554638 0.252171114858801 no 2515 0.213388015587225 3800 708429
SGTC_1571 st070080 73.4 µM -0.796764005968224 0.251573200199671 no 2516 0.21279405154797 3891 4315245
SGTC_1627 st003713 25.6 µM -0.796978050173257 0.251510611942202 no 2517 0.212731889645745 3895 16195070 YER133W GLC7
SGTC_80 0159-0065 512.242 µM -0.797882561160088 0.251246216484913 no 2518 0.212469322101641 3745 1548079
SGTC_1776 st049249 45.9 µM -0.798562765381965 0.251047484467503 no 2519 0.21227199261965 3887 1822314
SGTC_2809 7964133 12.99 µM -0.800338100742436 0.250529185282448 no 2520 0.211757466901103 3857 1253665
SGTC_2594 a-mangostin 100 µM -0.801583077969797 0.250166059663636 no 2521 0.211397084739555 3871 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1413 3910-0535 34.4 µM -0.802317725388603 0.249951914253416 no 2522 0.211184595804388 3841 2876951
SGTC_1855 st056195 39.6 µM -0.804111929197675 0.249429323575333 no 2523 0.210666167868675 3771 4028379
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.805112294088374 0.249138203575964 no 2524 0.210377440976909 3844 641818 YHR062C RPP1
SGTC_2050 5263056 171 µM -0.805624265905955 0.248989282652414 no 2525 0.210229764781285 3869 763468 YGL055W OLE1
SGTC_1456 k015-0012 13 µM -0.807309091196437 0.248499540028051 no 2526 0.209744213782588 3868 2989616
SGTC_252 miconazole 1.30953 nM -0.807630091226859 0.248406290441702 no 2527 0.20965177939099 3781 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_43 0570-0105 72.5 µM -0.807631349746011 0.248405924882212 no 2528 0.209651417038014 3857 1114046 YDL195W SEC31
SGTC_3063 1327-0034 4 µM -0.807635655983004 0.248404674060509 no 2529 0.209650177188559 3724 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_621 3584-0052 32.1 µM -0.808928052416645 0.24802942669447 no 2530 0.209278265979963 3826 2273927
SGTC_425 3825-7017 13.1 µM -0.810815070512925 0.247482074543459 no 2531 0.208735939285046 3949 3397440
SGTC_3299 9121982 43.1275 µM -0.811598508253729 0.247255018819074 no 2532 0.20851102377378 3919 17594604 YPL160W CDC60
SGTC_2093 5331342 194.4 µM -0.814678359542924 0.246363497767075 no 2533 0.207628221836704 3906 33839
SGTC_742 0kpi-0133 140 µM -0.814683426409958 0.246362032487796 no 2534 0.207626771302837 3914 2728852
SGTC_2959 9079155 11 µM -0.815239457242588 0.246201263195513 no 2535 0.207467628149324 3870 16189457
SGTC_2522 biochanin a 4.94 µM -0.816489861790608 0.245839930117743 no 2536 0.20711000982302 3841 5280373 A possible chelator.
SGTC_2595 hexamethylquercetagetin 100 µM -0.817549679259469 0.245533894564287 no 2537 0.20680718552233 3836 386331
SGTC_2373 9071805 200 µM -0.817908575305091 0.245430305248211 no 2538 0.206704696695894 3813 10149009
SGTC_3291 9121177 71.43 µM -0.8207777046837 0.244603024212228 no 2539 0.205886450164871 3873 17015612
SGTC_2718 lomofungin 53.02 µM -0.823053550133032 0.243947879527698 no 2540 0.20523877088464 3824 5351222 A RNA synthesis inhibitor.
SGTC_188 3229-0966 278.469 µM -0.826252299431946 0.24302866248459 no 2541 0.204330493087758 3915 5722370
SGTC_1432 4049-0298 68.4 µM -0.826262263676913 0.243025802012952 no 2542 0.204327667506491 3873 741646
SGTC_2703 st077852 53.4 µM -0.826276556392822 0.24302169898339 no 2543 0.204323614532509 3899 6281836
SGTC_1931 st074438 57.1 µM -0.826302228253146 0.24301432942132 no 2544 0.204316334903869 3845 2787313
SGTC_1539 benzyladenosine 56 µM -0.827233602367328 0.242747043753497 no 2545 0.204052334693433 3847 92208 A nucleotide analog.
SGTC_481 bay k-8644 50 µM -0.82756128252819 0.24265304398232 no 2546 0.203959501318871 3847 2303 A calcium channel antagonist.
SGTC_3107 9121808 49.47 µM -0.829341719452074 0.242142644644327 no 2547 0.20345553494031 3776 662681
SGTC_61 0978-8327 98.565 µM -0.830625896119675 0.241774870269023 no 2548 0.203092500411221 3829 6150059 YHR072W ERG7
SGTC_3343 9148379 18.9835 µM -0.830695549744713 0.241754930891445 no 2549 0.203072820515482 3936 1955036
SGTC_1177 0983-0204 23.6 µM -0.832758863057242 0.241164682003246 no 2550 0.202490369718593 3927 766818
SGTC_1572 epiandrosterone 68.9 µM -0.833970531142833 0.240818427390863 no 2551 0.202148795030435 3794 441302 A steroid.
SGTC_640 3381-0960 37.1 µM -0.834041265305949 0.24079822226904 no 2552 0.202128865407468 3914 1745025
SGTC_3260 9137109 49.47 µM -0.8345638896193 0.240648963902207 no 2553 0.201981650430947 3790 17478346
SGTC_1596 piperlongumine 63 µM -0.835035485859338 0.240514322083642 no 2554 0.201848864352509 3920 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2926 9010726 65.15 µM -0.835376945914891 0.240416860055826 no 2555 0.201752752998357 3912 2994293
SGTC_2745 rifampicin 24.3 µM -0.838170113719235 0.239620421922347 no 2556 0.200967584734483 3866 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2474 5321570 43.32 µM -0.838300417129901 0.239583302666293 no 2557 0.20093100084572 3905 2841384
SGTC_210 3551-0445 56.827 µM -0.838589960750914 0.239500832227326 no 2558 0.200849723098995 3907 2865180 YOR207C RET1
SGTC_3324 9138759 60.749 µM -0.839637562778255 0.239202574256971 no 2559 0.20055581575872 3939 45595710
SGTC_3128 9127691 49.47 µM -0.839925907918413 0.239120516468445 no 2560 0.200474965163323 3927 41316314
SGTC_1476 4112-3294 3.34 µM -0.842226757148624 0.23846628809337 no 2561 0.199830519656332 3929 704369
SGTC_561 1550-0330 72.9 µM -0.843393931636606 0.238134786245755 no 2562 0.199504082337385 3841 6812934
SGTC_1077 5-fluorocytosine 377 nM -0.845646176275653 0.237495816301435 no 2563 0.198875078749573 3918 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1886 st057356 49.9 µM -0.847325443899275 0.237020015098731 no 2564 0.198406874159261 3864 24207747
SGTC_2107 5363541 170.161 µM -0.848102578393006 0.236800000408806 no 2565 0.198190422905477 3882 244052
SGTC_3150 9097574 49.47 µM -0.848887347777349 0.236577938218743 no 2566 0.197971989867519 3903 17217476
SGTC_662 k832-1615 104 µM -0.848987128169683 0.236549712082692 no 2567 0.197944227374324 3949 5878478
SGTC_1767 st044992 70.3 µM -0.849271092755333 0.23646939358666 no 2568 0.19786523108548 3957 9600693
SGTC_1281 0884-0031 11.8 µM -0.85078225195715 0.236042219504712 no 2569 0.1974451612018 3904 1548255
SGTC_807 1315-0151 48 µM -0.850854077160045 0.236021926565799 no 2570 0.197425208768179 3879 4011080
SGTC_230 MPP+ 141.667 µM -0.851822017332893 0.235748546006795 no 2571 0.197156442126201 3907 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1066 ketoconazole 628 nM -0.851976196228416 0.235705016557566 no 2572 0.197113651930245 3970 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_509 pifithrin 175 µM -0.85251459918939 0.235553043595785 no 2573 0.196964269803432 3940 4817 A p53 inhibitor.
SGTC_1804 st050076 49.1 µM -0.857490616635238 0.23415104368027 no 2574 0.1955868992012 3939 3895976
SGTC_1718 roemerine 11.9335 µM -0.858490118372178 0.233869990961655 no 2575 0.195310942323803 3740 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1105 epirubicin 18.1 µM -0.858491402777552 0.23386962991638 no 2576 0.19531058785887 3927 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_806 3966-4455 5.86 µM -0.861781464534373 0.232945810636738 no 2577 0.194403893310655 3902 714982
SGTC_1116 jasmonic acid 1.58368 µM -0.861831910439017 0.232931661682849 no 2578 0.194390011107788 3984 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_272 doxorubicin 8.13 µM -0.863669942312192 0.232416460318708 no 2579 0.193884614999675 3898 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1684 st024538 14.6195 µM -0.86409684715255 0.232296889416529 no 2580 0.193767345425524 3897 6732859
SGTC_2331 7980721 200 µM -0.865139048159392 0.232005125288498 no 2581 0.193481237395683 3904 2981221
SGTC_2426 5582046 32.21 µM -0.866230217660873 0.231699871198319 no 2582 0.193181962704962 3932 2251934
SGTC_2043 5101342 149 µM -0.867094361016374 0.231458286434237 no 2583 0.19294515501596 3937 678451
SGTC_2814 7977482 42.97 µM -0.867635240187174 0.231307146712279 no 2584 0.192797024088923 4001 6456762
SGTC_2234 tolnaftate 200 µM -0.870719257513692 0.230446421780976 no 2585 0.191953730488524 3922 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3100 9120536 49.47 µM -0.871799178069245 0.230145448243552 no 2586 0.191658971539448 3767 16421196
SGTC_1037 k284-1091 78.7 µM -0.873478463616476 0.229677869012582 no 2587 0.191201169942698 3891 3334711
SGTC_854 0422-0053 192 µM -0.874617745682224 0.22936095119752 no 2588 0.190890964441321 3965 3596728
SGTC_1325 1431-0015 227 µM -0.875234120461614 0.229189594446994 no 2589 0.190723265734836 3910 1103340
SGTC_2183 6420625 130.508 µM -0.880460058680858 0.22773963315933 no 2590 0.189305066681099 3918 2897619
SGTC_2457 5731572 11.68 µM -0.880896212680737 0.227618854050738 no 2591 0.189186998782906 4021 2865357
SGTC_2448 5185112 27.17 µM -0.882160770226562 0.227268878618044 no 2592 0.188844936516791 3979 5718189
SGTC_2794 7785382 27.27 µM -0.882398394796787 0.227203148162852 no 2593 0.188780701735568 3862 2205081
SGTC_3246 9135460 32.98 µM -0.883004622224431 0.227035505274891 no 2594 0.188616887070841 3853 41446951
SGTC_1738 st035555 74 µM -0.883506891938435 0.22689666314386 no 2595 0.188481230245647 4020 5331140
SGTC_3190 9110366 49.47 µM -0.883833891808765 0.226806296501682 no 2596 0.188392943979483 3946 17123768
SGTC_3116 9124943 49.47 µM -0.886958664771751 0.225943788092366 no 2597 0.187550577640314 3938 41905195 YPL160W CDC60
SGTC_2004 4023728 41.89 µM -0.887658072895838 0.225750989849389 no 2598 0.187362352682405 3958 360084 YDR527W RBA50
SGTC_2980 9014342 25.29 µM -0.888518747706039 0.225513864742034 no 2599 0.187130887909609 4019 2996599
SGTC_3174 9107204 49.47 µM -0.889106077305768 0.225352130119896 no 2600 0.186973036543033 4003 3938802
SGTC_3257 9139206 32.98 µM -0.89161572439684 0.224661781857551 no 2601 0.186299469478797 3966 4910041
SGTC_912 3474-0017 2.18 µM -0.892430129761544 0.224438015058686 no 2602 0.186081213793683 4013 3360550
SGTC_945 3381-0768 11.3 µM -0.893313999159689 0.224195305447584 no 2603 0.185844521606075 4018 1126236 YIL048W NEO1
SGTC_1379 2144-0755 36.5 µM -0.893830948996471 0.22405342067032 no 2604 0.185706173720406 4038 5392327
SGTC_331 k048-0133 24.5 µM -0.894511275180495 0.223866772519343 no 2605 0.185524199898758 3931 6813582
SGTC_1034 k072-0165 12.7 µM -0.895603593914091 0.223567278731501 no 2606 0.185232257783956 4015 5835461
SGTC_933 2914-0560 114 µM -0.896717785336875 0.223262022757969 no 2607 0.184934763888512 4017 463887
SGTC_1744 st037937 38.9 µM -0.897033506616914 0.223175567484291 no 2608 0.18485051896579 4047 1016152
SGTC_684 1140-0066 328 µM -0.897821561833527 0.22295985421941 no 2609 0.18464034375259 4036 6813534
SGTC_1587 estradiol valerate 56.1 µM -0.898645072036211 0.222734562860179 no 2610 0.184420871490819 4023 13791 A steroid.
SGTC_1866 st057638 64 µM -0.900390377330001 0.222257521012112 no 2611 0.183956269945315 3939 688802
SGTC_1097 itavastatin 7.23 µM -0.900393877482287 0.222256564906501 no 2612 0.183955338935116 3970 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.900722461761054 0.222166818900049 no 2613 0.183867951429256 3944 688761
SGTC_3294 9122953 26.2835 µM -0.901528889608611 0.221946647484991 no 2614 0.183653590292012 3973 16459826
SGTC_3124 9127567 49.47 µM -0.902114363909405 0.221786879034101 no 2615 0.183498059671267 3974 17592030
SGTC_1846 st056244 14.8 µM -0.902698997124482 0.221627405681984 no 2616 0.183342834431258 4001 5393182
SGTC_390 dec-rvkr-cmk 16.7 µM -0.903082756357902 0.221522761373496 no 2617 0.18324098751574 4005 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2492 derrusnin 100 µM -0.903622128800706 0.221375731868726 no 2618 0.183097901641727 3877 1715307 Part of coumarin class of compounds.
SGTC_964 1287-0107 19.4 µM -0.904395325450258 0.22116506073246 no 2619 0.18289290799502 4009 51516812 YPR165W RHO1
SGTC_2840 9008771 71.43 µM -0.905295928354993 0.220919820172464 no 2620 0.182654316446096 3938 2992978
SGTC_2891 9063876 19.48 µM -0.905637810932111 0.220826763901683 no 2621 0.182563794377194 3970 6472478
SGTC_1242 0402-0103 60.1 µM -0.907468167677449 0.220328944996704 no 2622 0.182079637756735 3907 432868
SGTC_2130 NSC 7 2.4545 µM -0.907846417301277 0.220226149252602 no 2623 0.181979685269682 4035 21448
SGTC_3106 9121286 49.47 µM -0.909007656135192 0.219910734798466 no 2624 0.181673042243164 4010 15943471
SGTC_2111 5486399 200 µM -0.91038307440933 0.219537480745293 no 2625 0.181310260357542 3947 689674
SGTC_2738 aclarubicin 5.55 µM -0.910806109962279 0.219422752711347 no 2626 0.181198771301399 3930 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1331 1472-0049 76.2 µM -0.911598979159228 0.219207817911758 no 2627 0.180989929990688 3924 24051409
SGTC_3111 9122088 49.47 µM -0.912358293325514 0.219002092872084 no 2628 0.18079006850414 3842 16876704
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.91253723736729 0.218953626780831 no 2629 0.180742988228103 4007 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1616 st002734 56.1 µM -0.914973370057338 0.218294426526148 no 2630 0.180102805181192 3928 4026101
SGTC_2976 9009005 19.48 µM -0.915304778590384 0.218204838162014 no 2631 0.180015825585705 4015 2993148
SGTC_1943 st076331 65.2 µM -0.91532369910807 0.218199724092358 no 2632 0.180010860610448 4019 24208415
SGTC_1175 0741-0056 27.6 µM -0.915882472945282 0.218048722987371 no 2633 0.179864270289194 4086 765927
SGTC_1985 st071382 65.5 µM -0.91655091468518 0.217868164767208 no 2634 0.179689007904691 3973 6123237
SGTC_2320 7373003 200 µM -0.917656144735427 0.217569811346502 no 2635 0.179399457092363 4081 5415828
SGTC_3024 9090631 49.47 µM -0.918134267093849 0.217440816803607 no 2636 0.179274288403245 3951 25236383
SGTC_369 0957-0393 4.5 µM -0.920003778616321 0.21693685785605 no 2637 0.178785392315406 4031 6997992
SGTC_3014 9081533 49.47 µM -0.920046799930579 0.216925268674162 no 2638 0.178774151696861 4038 21367265
SGTC_198 3454-2873 16.191 µM -0.920496171735802 0.216804237243555 no 2639 0.178656766327116 3968 710957
SGTC_2948 9070189 9.45 µM -0.920633633671002 0.216767221771476 no 2640 0.178620868073787 3937 6473636 YDL196W YDL196W
SGTC_1198 1612-1005 86.7 µM -0.922270814641368 0.216326646022257 no 2641 0.178193666714066 4087 6998509
SGTC_2504 purpurogallin 52.29 µM -0.922658267906457 0.216222455801917 no 2642 0.178092660071142 3907 5281571 An antioxidant.
SGTC_873 0591-4978 488 µM -0.92654733668464 0.215178255368994 no 2643 0.177080804398558 4103 3305145
SGTC_3277 9138724 49.47 µM -0.926600078638963 0.215164114498118 no 2644 0.17706710703621 3940 15943418
SGTC_1732 st034308 51.822 µM -0.926969976138087 0.215064954857439 no 2645 0.176971061524412 3866 830119
SGTC_3202 9113761 49.47 µM -0.927602944720897 0.214895334448219 no 2646 0.176806784830641 4045 4798415
SGTC_811 0416-0114 265 µM -0.929391995142633 0.214416332224858 no 2647 0.176342987374497 4077 6612453
SGTC_3339 9145883 14.936 µM -0.933199686508752 0.213398926451003 no 2648 0.175358438285313 3932 2030670
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.933723777469384 0.213259111291823 no 2649 0.1752231982389 4031 2374 Ca(2+)-ATPase inhibitor.
SGTC_1338 1486-1223 76 µM -0.938874410383934 0.21188788807429 no 2650 0.173897614477623 4047 3444526
SGTC_2743 auranofin 4.32 µM -0.938878131286676 0.211886899347942 no 2651 0.173896659164913 3974 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1108 betulinic acid 729.144 nM -0.939154834383588 0.211813380764393 no 2652 0.173825627158648 4026 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1834 st055981 52.8 µM -0.940451586067851 0.211469039471558 no 2653 0.173492986057743 4049 471719 YDL150W RPC53
SGTC_323 4013-0906 34.3 µM -0.940686146824788 0.211406788901704 no 2654 0.173432860126544 4015 2910086
SGTC_1945 st075991 56.6 µM -0.942965915117231 0.210802315717892 no 2655 0.172849168739279 4054 1084980
SGTC_735 3076-0345 636 µM -0.944568904747724 0.210377895834412 no 2656 0.172439504179955 4089 2888990
SGTC_539 4859-0462 2.54 µM -0.945135417475704 0.210228021619904 no 2657 0.172294872812752 4080 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3327 9140648 26.9345 µM -0.945350183940288 0.21017122030716 no 2658 0.172240062919197 4042 8029710
SGTC_2873 9040596 71.43 µM -0.94555016289656 0.210118338091882 no 2659 0.17218903690455 4024 6463863
SGTC_2921 7974240 10.71 µM -0.945868892703911 0.210034069690997 no 2660 0.172107730730452 4127 2979074 YDR527W RBA50
SGTC_507 nimesulide 162 µM -0.947782983366361 0.209528424551464 no 2661 0.171619972569368 4089 4495 A COX2 inhibitor.
SGTC_739 1486-1183 203 µM -0.949100631786876 0.209180758026907 no 2662 0.171284716557142 4038 4346692
SGTC_1475 4092-1048 11.7 µM -0.950768213312396 0.208741247576798 no 2663 0.170861025979388 4055 2881759
SGTC_405 ebelactone b 50 µM -0.953201178452108 0.208100988565865 no 2664 0.17024407471815 4003 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2849 9019321 12.99 µM -0.955082017734793 0.207606822283964 no 2665 0.169768110946124 4063 16489627
SGTC_2704 st078022 71.1 µM -0.955686017599849 0.207448276311425 no 2666 0.16961544439641 4094 54697681
SGTC_1603 st002045 67.8 µM -0.957425571759727 0.206992054915344 no 2667 0.169176248260855 4033 5887985
SGTC_1976 st070609 63.5 µM -0.957899589843185 0.206867840326498 no 2668 0.169056696654749 3948 682556
SGTC_2641 levomentholum 100 µM -0.960511076410491 0.206184301969428 no 2669 0.168399029530758 4029 16666
SGTC_3283 9109332 35.8195 µM -0.961090257064557 0.206032887087933 no 2670 0.168253394027878 3878 17027281
SGTC_36 0335-0881 14.2 µM -0.961191933090963 0.206006312785888 no 2671 0.168227835860933 3953 23828853
SGTC_2030 5175110 200 µM -0.961456234607375 0.205937243787437 no 2672 0.168161410426719 4087 2831986
SGTC_606 k015-0008 38.6 µM -0.96239555748632 0.205691884980433 no 2673 0.167925472199084 4142 1970475
SGTC_1907 st060210 83.7 µM -0.963364804172221 0.205438891795506 no 2674 0.167682241225632 4099 688793
SGTC_2412 st077135 33.4 µM -0.963954794797345 0.205284982707634 no 2675 0.167534295127096 4144 13258915
SGTC_2905 7799065 20.05 µM -0.965826121113276 0.204797268804656 no 2676 0.167065597717981 3971 1296806
SGTC_884 0851-0618 334 µM -0.968491720189784 0.204103738960249 no 2677 0.166399426071826 4073 9642473
SGTC_2067 5224629 34.075 µM -0.969111935048935 0.203942573638585 no 2678 0.166244671734328 4062 2835000
SGTC_146 3448-8650 53.125 µM -0.970459548588134 0.203592652348933 no 2679 0.165908739375007 4042 2891488 YIL048W NEO1
SGTC_417 st075190 100 µM -0.971007313768767 0.203450522067693 no 2680 0.165772318270101 4056 222757
SGTC_2368 9071271 200 µM -0.971696401762483 0.203271806425066 no 2681 0.165600803699124 4059 27209959
SGTC_2399 5884133 200 µM -0.973490267275245 0.2028070052835 no 2682 0.165154847545394 4068 722445
SGTC_48 0382-0018 55 µM -0.976335810105401 0.20207101215923 no 2683 0.16444903981532 4084 762596
SGTC_1033 k072-0102 21.3 µM -0.976927836429835 0.201918087020396 no 2684 0.164302439827282 4042 5965931
SGTC_1062 mesoridazine 14.2 µM -0.978911423112194 0.201406215872914 no 2685 0.163811873742572 4065 4078 A neuroleptic.
SGTC_2347 9049783 174.81 µM -0.980091587052816 0.201102039983088 no 2686 0.163520455788285 4112 6467988 YPL169C MEX67
SGTC_1900 st060200 72.8 µM -0.980628789549945 0.200963672511643 no 2687 0.163387915915083 4049 688945
SGTC_3085 9117376 49.47 µM -0.98191973348256 0.200631397171035 no 2688 0.16306969659319 4153 16480349
SGTC_2850 9015429 58.44 µM -0.98300588954203 0.200352087737918 no 2689 0.162802270011304 4111 6457570
SGTC_2748 diazoxide 86.69 µM -0.98304666872313 0.2003416057581 no 2690 0.16279223517351 4100 3019 A potassium channel activatior.
SGTC_778 3456-2434 196 µM -0.984458101904329 0.199979010620713 no 2691 0.162445161180336 4043 5539063
SGTC_1808 st050063 61.5 µM -0.985116906816434 0.199809899753675 no 2692 0.162283324819521 4041 4011993
SGTC_935 2996-0153 430 µM -0.985124869551476 0.199807856298475 no 2693 0.162281369404567 4102 23738523
SGTC_1508 1080-0625 72.9 µM -0.985493885145368 0.199713170613013 no 2694 0.162190766788721 3941 767111
SGTC_991 3996-0057 64.7 µM -0.98641754233737 0.199476287856703 no 2695 0.161964130126191 4140 715343
SGTC_2759 disulfiram 3.38 µM -0.987162138856021 0.19928545049935 no 2696 0.161781579624306 3980 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1485 3909-9022 254 µM -0.989384199851193 0.198716598393515 no 2697 0.161237600999329 4098 714516
SGTC_1751 st044839 27.194 µM -0.990614550925978 0.198402047612011 no 2698 0.160936914882867 4075 5291326
SGTC_1885 st057546 99.9 µM -0.992299716659441 0.197971707083306 no 2699 0.160525670749423 4133 702008
SGTC_602 3130-1533 38.1 µM -0.993928950394034 0.197556186370054 no 2700 0.160128729411107 4111 720941
SGTC_1659 st012954 42.1 µM -0.997890676921867 0.196547987473788 no 2701 0.159166186657897 4068 24207262
SGTC_440 fluspirilene 35.1 µM -0.998894645091953 0.196292988874756 no 2702 0.15892286528044 4181 3396 An atypical antipsychotic.
SGTC_2744 captopril 92.04 µM -0.99924215076464 0.196204772404767 no 2703 0.158838700746191 4117 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1206 3978-0017 132 µM -0.999265981208559 0.196198723779714 no 2704 0.158832930175154 4189 3873677
SGTC_1148 3909-7663 27.7 µM -0.999846828453215 0.196051328543392 no 2705 0.158692319800109 4120 4084526
SGTC_1525 8-methoxypsoralen 92.5 µM -1.00032138388306 0.195930955683711 no 2706 0.158577500936713 4160 4114 Related to psoralen; DNA damaging agent.
SGTC_1441 4106-0040 13 µM -1.00195103236827 0.19551793042375 no 2707 0.158183621749538 4077 2904180
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.00232894440828 0.19542222631614 no 2708 0.158092373787463 4123 65057 A dermal irritant. YDR527W RBA50
SGTC_216 k038-0035 28.382 µM -1.00283399362517 0.195294369864039 no 2709 0.157970482135732 4026 4444231 YPR107C YTH1
SGTC_612 0302-0167 22.4 µM -1.00538150611945 0.194650225814581 no 2710 0.1573565907895 4102 235821
SGTC_3047 9092122 49.47 µM -1.00540129629711 0.194645226890848 no 2711 0.157351827963121 4068 17173831
SGTC_2663 amphotericin b 100 µM -1.00905349051349 0.193724034329297 no 2712 0.156474490786011 4095 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3164 9100705 49.47 µM -1.00909179567644 0.193714386729099 no 2713 0.156465306147539 4123 17174235
SGTC_2831 7999036 19.48 µM -1.01110047907444 0.193208887011471 no 2714 0.155984170555075 4150 2988270
SGTC_2588 indole-3-carbinol 100 µM -1.0114534511168 0.193120142288026 no 2715 0.155899724766722 4152 3712 Induces cell cycle arrest.
SGTC_314 1671-0008 2.74 µM -1.01277357050283 0.192788456668196 no 2716 0.155584163754904 3979 3913060
SGTC_2149 5554786 194.827 µM -1.0133289449471 0.192649020545128 no 2717 0.155451533183819 4128 745063 YPR165W RHO1
SGTC_2634 4'-methoxyflavone 100 µM -1.01446001216528 0.192365237676079 no 2718 0.155181650497803 4109 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1996 st072960 66.8 µM -1.0152867051595 0.192157983576856 no 2719 0.154984589976083 4147 1719405
SGTC_1411 3909-8223 150 µM -1.01634115323205 0.191893829017824 no 2720 0.154733478930511 4131 X1411
SGTC_2866 9034245 58.44 µM -1.01783013489046 0.191521196262775 no 2721 0.154379344148487 4065 6462273
SGTC_706 4262-0057 46.9 µM -1.01797202515252 0.191485709936077 no 2722 0.154345625396584 4102 883298
SGTC_2063 5246145 200 µM -1.01866217199392 0.191313163749224 no 2723 0.154181688594651 4143 711240
SGTC_359 0081-0058 15.9 µM -1.01956703689601 0.191087079533266 no 2724 0.153966922429415 4222 3494159
SGTC_2382 9035899 200 µM -1.02124643979936 0.190667908256673 no 2725 0.153568847556552 4096 6462679
SGTC_1800 st050079 29.0735 µM -1.02250082734042 0.190355187369588 no 2726 0.153271960636554 3979 3645560
SGTC_3018 9082602 49.47 µM -1.02326678359706 0.190164388210987 no 2727 0.153090862171336 4071 17332089
SGTC_1278 0874-0585 172 µM -1.02364164969508 0.190071052176298 no 2728 0.15300228261494 4182 766306
SGTC_1450 4112-4260 37.6 µM -1.02710458421018 0.189210165353007 no 2729 0.152185610151987 4106 1633175
SGTC_2415 st077333 57.7 µM -1.02943538192922 0.188632082183324 no 2730 0.151637564956324 4176 2766255
SGTC_1473 k844-0725 134 µM -1.03128785959747 0.188173409168213 no 2731 0.151202924895142 4173 54682906
SGTC_3062 9077494 49.47 µM -1.03324381314717 0.187689863247214 no 2732 0.150744907024834 4099 16459633
SGTC_1398 3558-0053 112 µM -1.0344955233166 0.187380821764884 no 2733 0.150452284269015 4039 4532369
SGTC_3215 9129942 49.47 µM -1.03553823853637 0.187123620477837 no 2734 0.150208809120871 4122 17682944
SGTC_1646 st011709 75.6 µM -1.03571517756766 0.18707999750232 no 2735 0.150167519740009 4071 5757843
SGTC_2563 tomatine 8.54 µM -1.03639131215712 0.186913359603257 no 2736 0.150009810914209 4059 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2487 5918373 44.05 µM -1.03689118401813 0.186790221904753 no 2737 0.14989328651148 4212 2876279
SGTC_182 3448-4371 550.524 µM -1.03927836065085 0.186202861034659 no 2738 0.149337647896794 4008 3491403
SGTC_2456 5770359 74.46 µM -1.04073434362525 0.185845181413981 no 2739 0.148999429644805 4157 3118787
SGTC_1221 2958-7315 257 µM -1.04265052521281 0.185375098430271 no 2740 0.148555089818522 4173 4562705
SGTC_3151 9099821 49.47 µM -1.04308325569843 0.185269042049488 no 2741 0.148454867501258 4115 17174189
SGTC_2150 5556613 200 µM -1.04354691238076 0.185155447899076 no 2742 0.148347532729863 4137 743190
SGTC_3089 9117425 49.47 µM -1.04501269833462 0.184796620465175 no 2743 0.148008550331489 4142 9401657
SGTC_1311 1190-0148 100 µM -1.0458143208098 0.184600564588044 no 2744 0.147823383995583 4195 1961333
SGTC_1469 k284-2957 126 µM -1.04654007154362 0.184423176557917 no 2745 0.147655877066179 4126 23884841
SGTC_2741 miltefosine 3.04 µM -1.04736885719534 0.184220734464098 no 2746 0.147464744700212 4129 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_12 0849-0099 9.267 µM -1.0481275708134 0.184035529715094 no 2747 0.14728991756262 4031 6071388
SGTC_1817 st052116 64.4 µM -1.04883026624328 0.183864102648693 no 2748 0.147128122416963 4162 4361398
SGTC_225 nsc-122657 1.016 µM -1.04920949370136 0.183771629005769 no 2749 0.147040855076017 4148 275685
SGTC_2436 5633522 8.09 µM -1.05057902209672 0.183437914324787 no 2750 0.14672598999873 4139 5724242
SGTC_2097 5376186 200 µM -1.05095801458872 0.183345631531647 no 2751 0.146638936694553 4117 742755
SGTC_93 0109-0045 59.227 µM -1.0515050631429 0.183212478976112 no 2752 0.146513342609811 4247 88733
SGTC_2288 7946289 167.31 µM -1.05258143491969 0.182950664372042 no 2753 0.146266434764391 4219 1246052
SGTC_350 k064-0020 19.8 µM -1.05491084297975 0.182384863482165 no 2754 0.14573305136347 4172 2790705
SGTC_2953 9074162 66.49 µM -1.05548526115714 0.182245508557199 no 2755 0.145601723408614 4150 16451992
SGTC_1270 0831-1170 17.3 µM -1.0558574015883 0.182155262121981 no 2756 0.145516684255639 4170 6764716
SGTC_1378 2093-0007 380 nM -1.05732554511316 0.181799500481116 no 2757 0.145181519345476 4221 3618014
SGTC_3168 9103419 49.47 µM -1.05793016002543 0.181653116184162 no 2758 0.145043641946363 4148 16649256
SGTC_1239 0337-0584 35.4 µM -1.05850102716006 0.181514970331174 no 2759 0.144913541366726 4230 914301 YML130C ERO1
SGTC_2490 carminic acid 95.39 µM -1.05905701830475 0.18138048759227 no 2760 0.144786906570181 4115 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2690 usnic acid 100 µM -1.06195379518306 0.180680826903549 no 2761 0.144128330767892 4192 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2524 avocatin b 10.57 µM -1.06228651012934 0.180600574500147 no 2762 0.144052818286105 4125 6710748
SGTC_1369 1866-0067 208 µM -1.06313234281005 0.1803966563661 no 2763 0.143860969522668 4178 3531355
SGTC_1245 0418-0076 17.2 µM -1.06337873178518 0.180337282695401 no 2764 0.143805116883152 4200 6790114
SGTC_1948 st076329 66.6 µM -1.06366634102089 0.180267991470199 no 2765 0.143739938744699 4024 24208413
SGTC_2413 inermin 26.06 µM -1.06495057126333 0.179958796804309 no 2766 0.143449149134778 4253 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_793 0488-0545 106 µM -1.06677297463412 0.179520602152204 no 2767 0.143037182538757 4188 292548
SGTC_1403 3909-7815 62.9 µM -1.06770577721788 0.179296570632028 no 2768 0.142826625809483 4116 6615483
SGTC_2752 diclazuril 33.15 µM -1.06810138584103 0.179201610287634 no 2769 0.142737390408296 4121 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1975 st070967 30.8 µM -1.07293213504037 0.178044608741997 no 2770 0.141650783284735 4156 261391
SGTC_2914 7968218 45.32 µM -1.0731838466131 0.177984451264998 no 2771 0.141594318417792 4130 2977111
SGTC_2828 7998861 71.43 µM -1.07387818508102 0.177818575204018 no 2772 0.141438640912079 4150 2988188
SGTC_3314 9135860 59.4275 µM -1.07774448929569 0.176896707071171 no 2773 0.140573899173144 4165 25252478
SGTC_156 3474-0145 5.642 µM -1.07795843589473 0.176845782736896 no 2774 0.140526152660717 3982 2265471
SGTC_3242 9133940 49.47 µM -1.08033077678493 0.176281730822444 no 2775 0.139997454635149 4180 17248444
SGTC_565 1418-0001 44.5 µM -1.08042236135584 0.17625997836251 no 2776 0.139977071302927 4249 2862145
SGTC_268 camptothecin 39.6153 µM -1.08209100398507 0.175863952695906 no 2777 0.139606046372765 4152 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2358 9037157 4 µM -1.08706130830131 0.174687672952884 no 2778 0.138504857931327 4181 2388925
SGTC_90 0870-0863 4.608 µM -1.0878827469282 0.174493752124685 no 2779 0.138323436805173 4210 1738164
SGTC_1056 3448-1962 115 µM -1.08893615044065 0.17424527044768 no 2780 0.138091021576015 4182 715507
SGTC_218 alverine citrate 93.75 µM -1.08955153516323 0.17410021476157 no 2781 0.137955370898647 4222 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2069 5228469 200 µM -1.09043229127864 0.173892740527808 no 2782 0.137761381977868 4194 2835210
SGTC_490 phenamil 164 µM -1.09857518259008 0.171982022144891 no 2783 0.135976703787484 4156 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1878 temozolomide 1 mM -1.09965253708112 0.171730230146552 no 2784 0.135741770965787 4117 5394 DNA alkylating agent.
SGTC_1830 st055982 50.3 µM -1.10003710527641 0.171640408527415 no 2785 0.135657977646104 4160 455313 An antimicrobial agent.
SGTC_103 0844-0104 51.839 µM -1.10115786918932 0.171378808686916 no 2786 0.135413977247164 4081 5375804
SGTC_2707 st078556 66.6 µM -1.10220092154702 0.171135576751067 no 2787 0.135187165722614 4128 17250899
SGTC_2271 7849410 118.62 µM -1.10377130736996 0.170769791258739 no 2788 0.134846177165473 4142 972430
SGTC_2630 antimycin a 100 µM -1.10387331661718 0.170746047855468 no 2789 0.134824047631686 4143 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2544 sphondin 68.51 µM -1.10680386697049 0.170064843056663 no 2790 0.134189367994531 4196 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_83 0170-0301 39.027 µM -1.10867538985365 0.16963072127221 no 2791 0.133785121142111 4207 3089716
SGTC_1679 SEC14.276 6.7 µM -1.1098584803355 0.169356656555239 no 2792 0.133530007204449 4202 1005053 YMR079W SEC14
SGTC_3080 9117754 49.47 µM -1.11065204644508 0.169172985093591 no 2793 0.133359075352859 4215 9550191
SGTC_404 fumagillin 50 µM -1.11210933392721 0.168836028058744 no 2794 0.133045571996509 4204 12015870 A methionine aminopeptidase binder.
SGTC_2384 9036245 200 µM -1.11416934256272 0.16836044475478 no 2795 0.132603272445536 4133 6462766
SGTC_2763 lisinopril 49.32 µM -1.11432270388871 0.16832507352735 no 2796 0.132570385160439 4088 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_860 0443-0016 25.1 µM -1.11507938658556 0.168150622347797 no 2797 0.132408202007665 4232 5337942
SGTC_3199 9111318 49.47 µM -1.11528028882213 0.16810432442234 no 2798 0.132365164722513 4144 8548020
SGTC_1565 sinapyl alcohol 95.1 µM -1.11765222495348 0.167558331881307 no 2799 0.131857777275582 4238 5280507 A phenol propionate derived from cinnamic acid.
SGTC_194 1486-1323 56.904 µM -1.11787013942204 0.167508227825024 no 2800 0.131811229972 4283 5178754
SGTC_3287 9117173 37.0625 µM -1.11893975596889 0.167262435866639 no 2801 0.131582920472811 4201 2789709
SGTC_564 3555-0129 330 µM -1.11944076706476 0.167147386278406 no 2802 0.131476073644583 4053 563260
SGTC_1264 0783-0040 158 µM -1.11971204747424 0.167085112149694 no 2803 0.131418244735431 4104 2855798
SGTC_2166 5933061 31.504 µM -1.1217578011414 0.166615978360934 no 2804 0.130982716482823 4357 2877375
SGTC_998 3996-0085 177 µM -1.12271553686916 0.166396642117955 no 2805 0.130779163610152 4249 715391
SGTC_555 4296-0685 37 µM -1.12345012552511 0.166228536388875 no 2806 0.130623185661792 4188 2908540 YHR072W ERG7
SGTC_2927 9011802 47.9 µM -1.12398431054307 0.166106360612091 no 2807 0.130509840971612 4227 43912568
SGTC_617 3770-0098 35 µM -1.12425190054726 0.166045180754471 no 2808 0.130453088643248 4122 5962639
SGTC_1986 st071812 45 µM -1.12669526063426 0.165487221993121 no 2809 0.129935673468256 4160 11838594
SGTC_3071 9117417 49.47 µM -1.13093251653069 0.164522493101574 no 2810 0.129041747985679 4173 45595590 YGL055W OLE1
SGTC_2933 9026794 32.47 µM -1.13096149220055 0.164515908559219 no 2811 0.129035649762717 4175 17586027
SGTC_3105 9121040 49.47 µM -1.13390660105085 0.163847541696102 no 2812 0.128416863950627 4109 41448907
SGTC_2928 9011484 9.79 µM -1.13556356964628 0.1634722827879 no 2813 0.128069631407944 4238 2994751
SGTC_1082 camptothecin 424.86 nM -1.13702217587659 0.163142409953316 no 2814 0.127764507677407 4113 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_697 0508-1955 564 µM -1.13786134871566 0.162952821994762 no 2815 0.127589191462552 4229 6243113
SGTC_1835 st008666 49.2 µM -1.13787858880301 0.162948928574692 no 2816 0.127585591495237 4158 690455
SGTC_749 1000-0129 128 µM -1.13836844896641 0.162838326138191 no 2817 0.127483331466857 4286 708470
SGTC_2064 5220758 200 µM -1.14025633924042 0.162412528032554 no 2818 0.127089760904032 4290 788518
SGTC_769 0302-0231 76 µM -1.14027528729016 0.162408258132225 no 2819 0.127085815073678 4141 571869 YER009W NTF2
SGTC_99 0109-0120 622.8 µM -1.14281299794513 0.161837050930987 no 2820 0.126558120493346 4192 759414
SGTC_2693 st077581 40.7 µM -1.14517706637741 0.1613061076162 no 2821 0.126067908200662 4264 25238761
SGTC_1113 artemisinin 1.17947 µM -1.14638943560103 0.161034264290854 no 2822 0.125817025972875 4267 2240 An anti-malaria and mitochondrial poison.
SGTC_1685 st024049 53.0905 µM -1.14717355738303 0.160858604002051 no 2823 0.125654948910305 4254 1941139
SGTC_788 1182-0090 188 µM -1.14798191447144 0.160677645481865 no 2824 0.125488014989984 4258 5715185
SGTC_1063 disulfiram 1.84 µM -1.148528292661 0.160555408789619 no 2825 0.125375270064546 4265 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2596 sinensetin 100 µM -1.15277869386988 0.15960657644695 no 2826 0.124500615837247 4259 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_98 0074-0023 107.663 µM -1.1530448074052 0.159547293286034 no 2827 0.124445996839974 4251 3563821
SGTC_127 0180-0333 59.125 µM -1.1551961650832 0.159068556167878 no 2828 0.124005052399408 4154 771601
SGTC_502 l-744,832 89.3 µM -1.15630801830781 0.158821507057175 no 2829 0.123777594876334 4264 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_117 lucigenin 22.078 µM -1.15791240866086 0.158465461793279 no 2830 0.123449891584428 4249 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_121 0557-0495 61.343 µM -1.16020126262999 0.157958427729008 no 2831 0.122983436520927 4334 3104427
SGTC_465 cgp-37157 41 µM -1.16051521438242 0.157888963323729 no 2832 0.122919551484208 4226 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_883 0850-0245 24.6 µM -1.160805620511 0.157824726443454 no 2833 0.122860478390571 4318 6823229 YPR165W RHO1
SGTC_2056 5235370 200 µM -1.164699933346 0.156964975803038 no 2834 0.122070237993312 4181 5511916
SGTC_487 nimodipine 119 µM -1.16519797082537 0.156855246289757 no 2835 0.121969433415039 4223 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2795 7780010 54.55 µM -1.16809696608498 0.156217530826972 no 2836 0.121383826993023 4225 953673
SGTC_1253 0550-0034 176 µM -1.16874435476917 0.156075353138308 no 2837 0.121253322857538 4285 5969915
SGTC_248 streptozotocin 5.23457 mM -1.17110832200207 0.155556909696191 no 2838 0.120777619599862 4282 5300 DNA alkylating agent.
SGTC_255 tunicamycin 200.472 nM -1.17127066246699 0.155521348419868 no 2839 0.120744999951444 4179 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_799 1310-0557 151 µM -1.1736853830187 0.154993028209091 no 2840 0.120260533567113 4316 5354492
SGTC_185 k048-0037 25.491 µM -1.17410990769412 0.154900268485712 no 2841 0.120175502748645 4318 6827589
SGTC_1583 clindamycin 39.6 µM -1.17414501341505 0.154892599438037 no 2842 0.120168473091553 4228 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2780 5215298 71.43 µM -1.17594469219202 0.154499785180394 no 2843 0.119808489019618 4283 2834131
SGTC_716 1683-5115 658 µM -1.17621493839434 0.154440855702047 no 2844 0.119754498255022 4243 723597
SGTC_1048 3161-0300 24.5 µM -1.17728955219551 0.154206674080005 no 2845 0.11953997778113 4266 2165101
SGTC_1008 4106-0037 6 µM -1.1773534557516 0.154192755513266 no 2846 0.119527229537398 4283 2905394
SGTC_2061 5245884 80.95 µM -1.17799498677744 0.154053072361895 no 2847 0.119399302416328 4248 573863
SGTC_2016 5121758 140 µM -1.17807425028244 0.154035819810148 no 2848 0.119383503260753 4194 2795203
SGTC_2837 9008476 45.46 µM -1.17815831521369 0.154017523573365 no 2849 0.119366748675447 4264 2992805
SGTC_1690 st023502 41.2 µM -1.17832901468272 0.153980376264428 no 2850 0.119332732474161 4266 24207482
SGTC_287 k060-0039 29.6 µM -1.17859134072312 0.153923300903771 no 2851 0.119280470688318 4302 5861974
SGTC_3303 9125618 40.5795 µM -1.17892884610468 0.153849889059102 no 2852 0.119213255096259 4270 22695467
SGTC_956 1185-0240 191 µM -1.1794402659313 0.153738692711364 no 2853 0.119111454679922 4248 1416193
SGTC_2089 5281248 129.67 µM -1.18016665676819 0.15358084738741 no 2854 0.118966968829109 4252 2737878
SGTC_3332 9141069 11.198 µM -1.18016918499292 0.153580298189581 no 2855 0.118966466158072 4219 17332883
SGTC_1493 4348-0038 111 µM -1.182077133242 0.153166211755689 no 2856 0.118587548357422 4237 800424
SGTC_1184 1269-1718 139 µM -1.18301490375176 0.152962956707724 no 2857 0.118401620413865 4317 5403821
SGTC_2119 5528445 120.635 µM -1.1838777955545 0.152776089130192 no 2858 0.118230720487752 4282 791935
SGTC_65 0798-0905 34.986 µM -1.18391376746051 0.15276830235437 no 2859 0.11822359986561 4340 3602145
SGTC_2147 5545932 89.7195 µM -1.18466444678608 0.15260586417211 no 2860 0.118075072429576 4304 797404
SGTC_3096 9117468 49.47 µM -1.18505929330775 0.152520470030411 no 2861 0.117997002123508 4182 41316311
SGTC_2622 2-methoxyxanthone 59.94 µM -1.18755806602616 0.15198079149928 no 2862 0.117503783560377 4257 71034 A hepatoprotective.
SGTC_586 0957-0265 8.15 µM -1.19071378029941 0.151301043046912 no 2863 0.116882983131244 4145 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2155 5570423 76 µM -1.1909326070215 0.151253982331766 no 2864 0.116840021315222 4239 797402
SGTC_339 3091-4833 71.4 µM -1.19120269582477 0.151195910657426 no 2865 0.11678701075205 4134 3240077
SGTC_2765 myclobutanil 7.74 µM -1.19312252948372 0.150783555531584 no 2866 0.116410694641667 4310 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2843 9000894 45.46 µM -1.19411289169963 0.150571131716245 no 2867 0.116216905510431 4217 2242070
SGTC_394 menadione 8.33 µM -1.19434842985479 0.150520640247871 no 2868 0.116170850297853 4282 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2929 9013348 24.6 µM -1.19454351655366 0.150478828753031 no 2869 0.116132714441721 4266 2995952
SGTC_1775 st081588 35.1725 µM -1.19504423982974 0.150371547839932 no 2870 0.116034872936976 4284 1426443 YGL099W LSG1
SGTC_2022 5136654 200 µM -1.19541627903634 0.150291870740072 no 2871 0.115962214244935 4306 1713771
SGTC_768 0384-0033 77.3 µM -1.19613957202136 0.1501370485452 no 2872 0.115821048679027 4244 3965305 YMR134W ERG29
SGTC_889 0919-1524 82.7 µM -1.19647122817945 0.150066092498142 no 2873 0.115756359953576 4294 3905452
SGTC_2919 7978188 46.38 µM -1.19672205526076 0.150012444246696 no 2874 0.11570745378726 4303 2980291
SGTC_1736 st036774 51 µM -1.19696766781271 0.149959923700324 no 2875 0.115659578571279 4334 1272247
SGTC_2685 mycophenolic acid 18.85 µM -1.19717194510353 0.149916251418179 no 2876 0.115619771214203 4269 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3353 9151644 39.2805 µM -1.19856448055712 0.149618768352994 no 2877 0.115348668218628 4302 4909158
SGTC_1061 3448-9325 110 µM -1.19962426360598 0.14939263428899 no 2878 0.115142649439392 4241 723482
SGTC_378 3970-0959 8.33 µM -1.1997784094591 0.149359762018246 no 2879 0.11511270573582 4315 6615653
SGTC_2742 clothiapine 36.27 µM -1.20143619738148 0.149006536801551 no 2880 0.114791020999996 4318 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2450 5739737 12.93 µM -1.20193055311742 0.148901312429085 no 2881 0.114695217868202 4305 2262825
SGTC_2650 prasterone 100 µM -1.2031317128863 0.148645850663207 no 2882 0.11446267751461 4281 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_664 1222-0054 14.9 µM -1.20327325496956 0.148615766906905 no 2883 0.114435297579783 4257 6813991
SGTC_2915 7971052 15.16 µM -1.20482976085051 0.148285211233892 no 2884 0.114134514222148 4198 5741558
SGTC_358 0075-0058 9.45 µM -1.20627835675108 0.147978014646334 no 2885 0.11385508997278 4196 1069125
SGTC_259 usnic acid 108.925 µM -1.20689042627907 0.147848344191311 no 2886 0.113737172569062 4353 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1913 st060213 96.1 µM -1.20836403477768 0.147536463894217 no 2887 0.113453633711627 4310 688959
SGTC_2491 paeonol 100 µM -1.2099184166294 0.147207966380698 no 2888 0.11315509981467 4237 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1893 st059353 36.1 µM -1.21045153765579 0.147095411491283 no 2889 0.113052838024288 4307 3112488
SGTC_3060 1327-0027 12.5 µM -1.21107411815421 0.146964042574876 no 2890 0.112933499869962 4212 16000455 YPR107C YTH1
SGTC_2829 7992743 58.44 µM -1.21121124577288 0.146935118248481 no 2891 0.112907226912298 4294 16462845
SGTC_1120 ficusin 1.78878 µM -1.21217779009454 0.146731353372364 no 2892 0.112722165664748 4314 6199 A DNA cross-linker.
SGTC_1384 3089-0840 101 µM -1.21258919577646 0.146644679228658 no 2893 0.112643460845325 4285 1069836
SGTC_3337 9144342 33.5465 µM -1.21358144436185 0.146435775624556 no 2894 0.112453798159759 4292 17682949
SGTC_2088 5278280 127.392 µM -1.21537275814628 0.146059146507815 no 2895 0.112111976614645 4347 791502
SGTC_690 glyoxal 20.3 µM -1.2161666551165 0.145892435581066 no 2896 0.111960721610447 4098 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2532 xanthone 78.9 µM -1.22003620264742 0.145081697934799 no 2897 0.111225575635247 4306 7020 An insecticide.
SGTC_838 0109-0203 71.4 µM -1.22218778044486 0.144632219136719 no 2898 0.110818311879192 4333 759422
SGTC_713 1488-1073 324 µM -1.22655011571216 0.143723780197389 no 2899 0.109995864086466 4325 3312542
SGTC_1579 chlormadinone acetate 49.4 µM -1.22762584905227 0.143500356095958 no 2900 0.109793726837349 4360 45114258 A steroidal progestin.
SGTC_1127 asiatic acid 681.4 nM -1.23008946790518 0.142989559299919 no 2901 0.109331801786759 4245 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_888 0916-0002 6.97 µM -1.23682657810868 0.141598993949842 no 2902 0.108075736325621 4355 2802138 YIL048W NEO1
SGTC_1 0258-0098 57.368 µM -1.23730385169072 0.141500831553536 no 2903 0.107987149232372 4259 6790032 YDR047W HEM12
SGTC_67 0335-0847 266 µM -1.2378395659022 0.141390704423265 no 2904 0.107887777227062 4405 4552207 YOR254C SEC63
SGTC_220 paclitaxel 373.376 µM -1.23935267946539 0.141079966464105 no 2905 0.107607458824406 4280 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2425 5628681 7.85 µM -1.24054553926796 0.140835323562455 no 2906 0.107386840647669 4387 5714958
SGTC_222 nsc-310342 10.666 µM -1.2414145307432 0.140657283937016 no 2907 0.10722632698325 4343 432556
SGTC_661 1304-0007 33.6 µM -1.24180772318224 0.140576776590945 no 2908 0.107153756263317 4319 3117130
SGTC_726 3448-4391 34.2 µM -1.24509758530143 0.139904393097052 no 2909 0.106547940817244 4417 1356692
SGTC_2585 alliin 100 µM -1.24609019325333 0.139701953370502 no 2910 0.106365642364318 4386 87310 A garlic compound which reacts with lipids.
SGTC_1856 st057054 55.7 µM -1.24679120742035 0.139559103464942 no 2911 0.106237032647813 4330 1266018
SGTC_21 0849-0113 22.993 µM -1.24817883219276 0.139276631773461 no 2912 0.105982787019144 4290 1560156
SGTC_320 4092-0846 5.34 µM -1.24909029524068 0.139091301725188 no 2913 0.105816024892987 4280 1359356
SGTC_2648 atorvastatin 78.68 µM -1.25104652278794 0.138694104078291 no 2914 0.105458752241592 4327 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1147 3809-1045 12.3 µM -1.25483961427404 0.137926147963101 no 2915 0.104768494336639 4313 325925
SGTC_2988 9073640 71.4286 µM -1.25643764931265 0.137603477000692 no 2916 0.104478669307252 4380 9102229
SGTC_2255 7941087 197.44 µM -1.25644991450357 0.137601002440259 no 2917 0.104476447099418 4441 935561
SGTC_1307 1187-1599 12.2 µM -1.2575595938771 0.137377245047317 no 2918 0.104275537024308 4329 1538471
SGTC_1219 1469-0211 33.1 µM -1.25782522946419 0.137323718771699 no 2919 0.10422748463962 4343 6822282
SGTC_798 1287-0182 476 µM -1.25920033395446 0.13704685928063 no 2920 0.103978990490103 4376 1649755
SGTC_3103 9120822 49.47 µM -1.26360920855504 0.136161762332703 no 2921 0.103185163381358 4342 17141819
SGTC_2045 5106652 78.05 µM -1.26474904289655 0.135933574484295 no 2922 0.102980651661312 4301 673349
SGTC_2394 5221648 200 µM -1.26587967756404 0.135707487158218 no 2923 0.102778081623925 4370 788586
SGTC_1004 4084-0029 199 µM -1.26886211356166 0.135112340775908 no 2924 0.102245123479685 4353 716894 YLR208W SEC13
SGTC_823 0417-1665 178 µM -1.26886422455667 0.135111920160783 no 2925 0.102244746960395 4348 3429856
SGTC_3265 9137266 49.47 µM -1.27312519293619 0.134264753008957 no 2926 0.101486810247377 4302 17224265
SGTC_2269 7935389 174.42 µM -1.27356761747154 0.134176999538866 no 2927 0.10140834735171 4309 97605
SGTC_3133 9127736 49.47 µM -1.27375914373381 0.134139023148398 no 2928 0.101374394352122 4350 27243420
SGTC_1687 st020778 55.3625 µM -1.27790480782634 0.133318818035544 no 2929 0.100641496327836 4359 4259299
SGTC_2819 7996655 46.38 µM -1.27886790597982 0.133128767390664 no 2930 0.100471788044304 4311 6456960
SGTC_669 0108-0021 26.2 µM -1.28427415167406 0.132065400512328 no 2931 0.0995230238663543 4374 17201
SGTC_646 4092-0839 27.3 µM -1.28436913624219 0.132046770285204 no 2932 0.0995064133690682 4374 877796
SGTC_1811 st050069 61.5 µM -1.28508369665912 0.131906674853754 no 2933 0.0993815190352681 4334 3877702
SGTC_688 0527-0193 473 µM -1.2861194161723 0.131703795603991 no 2934 0.099200694442433 4401 4007154
SGTC_145 3737-0113 38.366 µM -1.28659044357286 0.131611600879925 no 2935 0.0991185381664929 4322 6849351
SGTC_583 1488-1091 88.9 µM -1.29056702095658 0.130835036171183 no 2936 0.0984269289349708 4461 4303273
SGTC_1529 apigenin 74 µM -1.29630522126166 0.129720044915377 no 2937 0.0974351752303317 4373 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1797 st048695 56.8 µM -1.29816443312268 0.129360196581801 no 2938 0.0971154185242997 4322 592262 YIL048W NEO1
SGTC_959 1222-0044 107 µM -1.29881505265951 0.129234433467596 no 2939 0.0970037037779048 4345 6083612
SGTC_197 4544-0043 41.561 µM -1.30001892834193 0.12900195088857 no 2940 0.0967972409022124 4375 896523
SGTC_2739 tacrine 100.86 µM -1.30091565776182 0.128828970447792 no 2941 0.0966436629813043 4412 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3125 9127534 49.47 µM -1.30183573397731 0.128651653682126 no 2942 0.096486272690395 4258 1639235
SGTC_3131 9127911 49.47 µM -1.3022629001927 0.128569387949203 no 2943 0.0964132647315328 4392 45595681
SGTC_116 0155-0182 31.788 µM -1.30446257040676 0.128146342903938 no 2944 0.0960379566936264 4242 771486
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.30705954048176 0.127648134052865 no 2945 0.0955962454442526 4399 165521
SGTC_2747 doxorubicin 7.63 µM -1.30725919155607 0.127609888335629 no 2946 0.09556234934714 4393 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1516 st013856 110 µM -1.31759465298966 0.125640871655547 no 2947 0.0938196882536187 4410 5281404 A mutagen and neurotoxin.
SGTC_477 mead ethanolamide 10 µM -1.31838649107413 0.125490897019955 no 2948 0.093687150326857 4335 16061185
SGTC_2787 5284540 71.43 µM -1.31928712989608 0.125320467378522 no 2949 0.0935365694181463 4405 736958
SGTC_151 3013-0144 2.285 µM -1.31992955099366 0.125198999560235 no 2950 0.0934292700890138 4189 906558 YHR107C CDC12
SGTC_361 000s-0510 1.45 µM -1.32323396811851 0.124575505407381 no 2951 0.092878791529571 4290 660
SGTC_810 3825-7150 143 µM -1.32493654864598 0.124255102598673 no 2952 0.0925960986694121 4420 22330411 YGL099W LSG1
SGTC_49 0717-0965 32.132 µM -1.33031516024498 0.123246708443485 no 2953 0.091707227121916 4452 5889349 YGL099W LSG1
SGTC_1458 k015-0034 6.33 µM -1.33077897524535 0.123160020721311 no 2954 0.0916308739564623 4421 3598957
SGTC_983 1491-0821 12.2 µM -1.33084903794248 0.123146929613741 no 2955 0.0916193443405539 4365 46495113
SGTC_1188 1403-0014 4.57 µM -1.33087100320992 0.123142825637999 no 2956 0.0916157299266171 4396 9614867
SGTC_2834 9001755 58.44 µM -1.33136806806209 0.12304998000448 no 2957 0.0915339654915023 4277 2989575
SGTC_554 4483-2211 187 µM -1.33175128971205 0.122978432396291 no 2958 0.0914709645655076 4446 747107
SGTC_3313 9133968 57.047 µM -1.3369447901573 0.122011679366527 no 2959 0.0906203294999188 4381 1494643
SGTC_1837 st055472 66.5 µM -1.33919295356385 0.121594850780588 no 2960 0.0902539328906958 4448 676091
SGTC_2025 5147754 141 µM -1.33995110222584 0.12145450950897 no 2961 0.0901306213052407 4351 315777 YLR208W SEC13
SGTC_537 1334-0398 209 µM -1.34031213729828 0.121387718169187 no 2962 0.0900719435792889 4416 5846986
SGTC_908 3448-7491 47.7 µM -1.34226186638598 0.121027465410206 no 2963 0.0897555515969751 4411 1203031
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.34448774111758 0.120617109371199 no 2964 0.0893953589724886 4391 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_952 1185-0122 232 µM -1.34627046416767 0.120289158753395 no 2965 0.0891076537603693 4353 678600
SGTC_3084 9116877 49.47 µM -1.34863474537545 0.119855194111663 no 2966 0.0887271573583299 4357 27241325
SGTC_1020 4335-0961 93.3 µM -1.35073164369967 0.119471232313925 no 2967 0.0883907059289844 4363 669075
SGTC_3207 9114163 49.47 µM -1.35228637214586 0.119187107730367 no 2968 0.0881418611243756 4401 849233
SGTC_2029 5175081 200 µM -1.35240517218971 0.119165416810096 no 2969 0.088122867873489 4354 1380876
SGTC_1782 st039423 80.636 µM -1.35263267220218 0.119123886853899 no 2970 0.0880865046454847 4423 2068169
SGTC_553 k007-0256 45.7 µM -1.3561315084649 0.118486463586621 no 2971 0.087528664655538 4466 6287000
SGTC_1262 0737-0114 49.6 µM -1.35740930526378 0.118254274671119 no 2972 0.0873255965986402 4440 765919
SGTC_2564 betulinic acid 100 µM -1.36194384069657 0.117432899782698 no 2973 0.0866078045370553 4444 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3139 9095020 49.47 µM -1.36299567126418 0.117242952316115 no 2974 0.086441937429439 4256 25236292
SGTC_578 3460-0051 92 µM -1.36316257377824 0.117212831823814 no 2975 0.0864156397943525 4473 2876744
SGTC_748 act1.228 77.9 µM -1.36545825352804 0.116799092198564 no 2976 0.0860545327379668 4386 4421505 YNR035C ARC35
SGTC_1606 st000094 49.2 µM -1.36595574039622 0.116709569120272 no 2977 0.0859764278347945 4429 1242210
SGTC_1573 oleylamine 1.06 µM -1.37145431140027 0.115723337202488 no 2978 0.0851166883978284 4412 5356789 An amine of the fatty acid oleic acid.
SGTC_609 0986-0026 86.3 µM -1.37151265182779 0.115712905008581 no 2979 0.0851076011391313 4386 2848610
SGTC_2881 9058953 51.95 µM -1.37332679364747 0.115388840948685 no 2980 0.0848253883243886 4356 17122249
SGTC_2036 5160441 105 µM -1.37521230311797 0.115052712436772 no 2981 0.0845328175672654 4387 134534 YIL048W NEO1
SGTC_200 k038-0079 37.545 µM -1.3757794677633 0.114951740731309 no 2982 0.084444960025895 4414 3436683
SGTC_1636 st007707 68.9 µM -1.37753074024659 0.114640361399673 no 2983 0.0841741087481876 4430 403051
SGTC_1104 tacrolimus 29.8 µM -1.37822256301211 0.114517519636071 no 2984 0.0840672915169403 4490 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3061 glucosamine 200 µM -1.38066816441288 0.114084023684813 no 2985 0.0836905070646277 4352 91431 and experimental redox chemotherapeutic
SGTC_3149 9097855 49.47 µM -1.38234651325023 0.113787204518924 no 2986 0.0834326653044791 4418 25236625 YMR079W SEC14
SGTC_266 formosanin C 406 nM -1.3833887176795 0.113603165928588 no 2987 0.0832728540467809 4273 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2006 4011487 200 µM -1.3845635882156 0.113395954948661 no 2988 0.0830929758815409 4399 45595294
SGTC_2740 felodipine 17.08 µM -1.38918579669652 0.112583356415271 no 2989 0.0823881297833328 4479 3333 L-type calcium channel blocker
SGTC_3328 9140624 29.0385 µM -1.39016473835125 0.112411790481825 no 2990 0.0822394291855755 4430 4904392
SGTC_1454 4239-0054 42.6 µM -1.39539238246884 0.111498773516723 no 2991 0.081448773583115 4494 1340767
SGTC_1483 3453-0561 55.9 µM -1.39566440473614 0.111451410040215 no 2992 0.0814077890133335 4467 4546991
SGTC_1719 st032227 49.2 µM -1.39577037253452 0.111432963230263 no 2993 0.0813918274552454 4430 3125804
SGTC_2237 6667747 47.222 µM -1.39579993761173 0.11142781694949 no 2994 0.0813873745924774 4433 729940 YDL015C TSC13
SGTC_2647 atorvastatin 60.16 µM -1.39917841083594 0.110840858817326 no 2995 0.0808797444575268 4404 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_548 1436-0017 110 µM -1.40272975060901 0.110226259358268 no 2996 0.0803487210954402 4466 9677137
SGTC_3251 9135047 49.47 µM -1.40730029685222 0.109438876990167 no 2997 0.0796691806793524 4482 17682963
SGTC_942 3253-1115 227 µM -1.40894137820668 0.109157150740505 no 2998 0.0794262514663107 4460 46497897
SGTC_2581 avocatin a 64 µM -1.41142990160087 0.108730938098012 no 2999 0.0790589456633867 4382 6710728 A skin care supplement.
SGTC_2848 9016370 25.97 µM -1.41470540799205 0.108171763966818 no 3000 0.0785774440542058 4421 7894410
SGTC_1827 berberine 7.24 µM -1.41970134840104 0.107322879305254 no 3001 0.0778473227055108 4350 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.42404392791429 0.106588920756914 no 3002 0.0772168781725303 4393 1241132 A phosphatase inhibitor.
SGTC_1039 k821-0043 94 µM -1.42955778979075 0.10566222862038 no 3003 0.076421988780764 4432 15992768
SGTC_418 lividomycin a 100 µM -1.43415364288756 0.10489428493679 no 3004 0.0757642113190488 4469 72394 An antibiotic.
SGTC_1098 clofazimine 15.1 µM -1.43594790751073 0.104595571833895 no 3005 0.0755085824195363 4511 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3041 9091929 49.47 µM -1.43916982737395 0.104060727170679 no 3006 0.0750512059340812 4449 25236887
SGTC_2321 7390090 138.78 µM -1.43976153275499 0.103962718891989 no 3007 0.07496743889479 4459 649046
SGTC_11 0438-0307 1.3 µM -1.43976830625503 0.103961597337719 no 3008 0.0749664803913219 4447 4011476
SGTC_1652 st011932 78 µM -1.44134327708486 0.103701052261976 no 3009 0.0747438633228191 4393 1551076
SGTC_2858 9025781 8.96 µM -1.44177839080805 0.103629155637212 no 3010 0.0746824504120693 4298 4894980 YPL153C RAD53
SGTC_3068 9116768 49.47 µM -1.44191744403684 0.103606186610604 no 3011 0.0746628322541869 4429 41904888
SGTC_833 3852-0053 558 µM -1.44463875005262 0.103157420441482 no 3012 0.074279691216812 4525 3123681
SGTC_1387 3342-1166 1.8 µM -1.44475518846494 0.103138250312769 no 3013 0.0742633310539744 4442 3418228
SGTC_774 k060-0086 136 µM -1.44698682093108 0.102771339765053 no 3014 0.0739503073697228 4459 5911235
SGTC_1760 st045453 10.4495 µM -1.44783494638469 0.102632145513683 no 3015 0.0738316083631944 4491 3323419 YIL048W NEO1
SGTC_1674 st016616 23.6 µM -1.45208320609432 0.101936983675916 no 3016 0.0732392354648949 4414 625830
SGTC_2253 7938677 135.83 µM -1.46193585868026 0.100337952673521 no 3017 0.071879393709282 4522 2301972
SGTC_1590 st077108 57.8 µM -1.46346835118912 0.100090891814503 no 3018 0.0716696337902469 4486 5489485
SGTC_886 0866-0150 153 µM -1.46601550239 0.0996812358258084 no 3019 0.0713220317864892 4511 271463
SGTC_587 k089-0003 57 µM -1.47184873927587 0.0987476995660402 no 3020 0.0705308643220377 4399 9659696
SGTC_619 1652-1634 108 µM -1.47266432680878 0.0986176865515869 no 3021 0.0704207850674719 4467 5400454
SGTC_734 2023-0417 80 µM -1.47296190481855 0.0985702807790534 no 3022 0.0703806540859566 4492 3935732
SGTC_1952 st077036 64.1 µM -1.47439343324869 0.0983424637684659 no 3023 0.0701878457503979 4493 2937007
SGTC_1867 st057372 64 µM -1.47455937447176 0.098316080428551 no 3024 0.0701655219189397 4445 688837
SGTC_2983 9022671 12.99 µM -1.47477366970828 0.0982820168538926 no 3025 0.0701367011731562 4455 6405161
SGTC_1158 4092-0494 91.8 µM -1.47617214315319 0.098059932963149 no 3026 0.0699488428763751 4565 1148199
SGTC_829 1635-0120 117 µM -1.47647736729349 0.0980115109151836 no 3027 0.0699078933406403 4471 285054
SGTC_3065 9113888 49.47 µM -1.47698089291598 0.0979316677799437 no 3028 0.0698403795679419 4496 16648368
SGTC_717 1532-0246 73.2 µM -1.47956689481503 0.097522361178264 no 3029 0.069494433379539 4453 9561992
SGTC_2181 6316240 54.2555 µM -1.4917183947148 0.0956158407089568 no 3030 0.067886492392819 4501 12779990
SGTC_2781 5567276 71.43 µM -1.49219777998614 0.0955411934787038 no 3031 0.0678236520914157 4490 2853274
SGTC_863 0466-0191 129 µM -1.49548671871253 0.0950302142791654 no 3032 0.0673937317645926 4536 765160 YPR165W RHO1
SGTC_445 e6 berbamine 66 µM -1.50169834348721 0.0940706541177304 no 3033 0.0665875159541092 4501 6610268 A calcium/calmodulin antagonist.
SGTC_518 1021-0119 62.6 µM -1.50312958377141 0.0938505756852118 no 3034 0.0664028156758034 4469 1097762
SGTC_1879 gemcitabine 100 µM -1.50439731023676 0.0936559579775585 no 3035 0.0662395482199821 4453 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2602 kawain 100 µM -1.50517848816137 0.0935361822745545 no 3036 0.0661390971112897 4467 5369129
SGTC_1025 k007-0731 70 µM -1.50567224989677 0.0934605336187506 no 3037 0.0660756655345912 4475 6256118
SGTC_1737 st035557 69.7 µM -1.50572553986227 0.0934523718282472 no 3038 0.0660688224066066 4339 5716916
SGTC_148 3253-0744 288.01 µM -1.50651982685352 0.0933307827281961 no 3039 0.0659668906458349 4383 6893655
SGTC_1783 st039459 87.517 µM -1.50872648833907 0.0929936013978501 no 3040 0.065684346743581 4560 729761
SGTC_2859 9028643 45.46 µM -1.50977100805316 0.0928343115085844 no 3041 0.0655509326085085 4326 17151580
SGTC_2820 7989630 71.43 µM -1.50990090300949 0.0928145165622929 no 3042 0.0655343561213189 4528 2984098
SGTC_2791 5663188 71.43 µM -1.51096641878627 0.0926522583238816 no 3043 0.0653985034684255 4496 54690634
SGTC_2021 4019055 173 µM -1.51339708043897 0.0922828991497493 no 3044 0.0650894130822737 4288 44827708 YER133W GLC7
SGTC_1457 k015-0032 57.3 µM -1.51609346357788 0.0918744376820278 no 3045 0.0647478604407184 4488 4302660
SGTC_2017 5132927 60.65 µM -1.51769017494798 0.0916331920350304 no 3046 0.0645462610309122 4485 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2379 9035213 200 µM -1.5184708602307 0.0915154100080845 no 3047 0.0644478700273621 4512 646551
SGTC_2270 7924575 90.91 µM -1.52424078862161 0.0906483777605801 no 3048 0.0637242861538269 4482 1262135
SGTC_3262 9137218 49.47 µM -1.52440144242515 0.0906243242741799 no 3049 0.0637042300046703 4500 17650664
SGTC_1511 0906-3109 28.5 µM -1.52555217520634 0.0904521721891745 no 3050 0.0635607151386661 4512 2882180
SGTC_2463 5473429 200 µM -1.53370379208684 0.0892396197221645 no 3051 0.062551270224517 4513 5399405
SGTC_3095 9117207 49.47 µM -1.53406666791386 0.0891859245223566 no 3052 0.0625066262108372 4515 17015229
SGTC_1924 st058459 75.1 µM -1.53986058499226 0.0883318448547118 no 3053 0.0617971700936921 4474 688683
SGTC_410 α-linolenic acid 100 µM -1.53991628631034 0.088323663624194 no 3054 0.0617903801878092 4543 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1348 1493-0373 93.8 µM -1.54081275419144 0.0881920709726806 no 3055 0.0616811822093838 4537 3010129
SGTC_162 k030-0015 37.8 µM -1.5416779100165 0.088065213252377 no 3056 0.061575941251492 4566 1809920 YMR134W ERG29
SGTC_3144 9087057 49.47 µM -1.541714920553 0.0880597894368537 no 3057 0.0615714422738022 4440 17249618
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.54180058906696 0.0880472358535363 no 3058 0.0615610294475505 4495 688803
SGTC_2584 androsterone 48.74 µM -1.54357346133341 0.0877877444063848 no 3059 0.0613458491481882 4410 2754130 A steroid.
SGTC_3058 9093861 49.47 µM -1.54659233483437 0.0873471919090662 no 3060 0.0609807896166188 4525 17217477
SGTC_1255 0566-0045 221 µM -1.54715918177165 0.0872646547415945 no 3061 0.060912432991006 4527 2788469
SGTC_2263 7948595 193.29 µM -1.54798522070193 0.0871444815505797 no 3062 0.0608129274281267 4539 2971371
SGTC_2746 daunorubicin 9.88 µM -1.54802894850144 0.0871381234208021 no 3063 0.0608076634736591 4535 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1678 st019265 80.2 µM -1.54806113565305 0.0871334435510124 no 3064 0.0608037890105705 4498 5367020
SGTC_111 0083-0039 52.457 µM -1.54816352849434 0.0871185573320602 no 3065 0.0607914649638478 4493 759313
SGTC_3069 9117009 49.47 µM -1.54974474846539 0.0868889152778222 no 3066 0.0606013965438362 4509 41904981
SGTC_2124 5246320 200 µM -1.55057956368003 0.0867678568421952 no 3067 0.0605012363790077 4523 579342
SGTC_2180 6301957 200 µM -1.55261684533131 0.0864729551999018 no 3068 0.0602573494065248 4541 845462
SGTC_3297 9117502 71.43 µM -1.55446109103844 0.0862066427900985 no 3069 0.0600372353949962 4541 7453720
SGTC_746 1095-0025 46.6 µM -1.55883680003218 0.0855772377200153 no 3070 0.0595175059002973 4542 6749286
SGTC_1700 st030840 7.9285 µM -1.56050425329514 0.0853382976899585 no 3071 0.0593203828201292 4571 5499307
SGTC_2516 gossypol 71.55 µM -1.56158298106562 0.085183986352892 no 3072 0.0591931306658823 4542 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_110 0850-0284 111.64 µM -1.5620616830543 0.0851155753478636 no 3073 0.0591367291952719 4439 3906265
SGTC_505 gw-5074 63.9 µM -1.56230599274109 0.0850806770741013 no 3074 0.0591079604683223 4538 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_845 0330-0138 4.51 µM -1.56374213318002 0.0848757492044669 no 3075 0.0589390693860368 4489 9039800
SGTC_2839 9003951 25.97 µM -1.56644577643163 0.0844909613959395 no 3076 0.0586221466974747 4583 2990634
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.56652636266093 0.0844795123245577 no 3077 0.0586127209037296 4569 165506
SGTC_2708 st078559 56 µM -1.57480489739514 0.0833095532911977 no 3078 0.057650742825724 4492 17250902
SGTC_970 1315-0089 19.5 µM -1.57683552496009 0.0830244451412336 no 3079 0.0574166875701986 4518 6811083 YLR033W RSC58
SGTC_1451 4152-0210 104 µM -1.57763150245212 0.082912887183607 no 3080 0.057325145409686 4562 659563
SGTC_1727 st034309 9.9045 µM -1.57965248794772 0.0826301483858522 no 3081 0.0570932359613092 4550 870305
SGTC_2863 9028737 58.44 µM -1.58341826962006 0.0821052468838379 no 3082 0.0566630807883825 4526 6460917
SGTC_2664 lyso-paf C-16 73.48 µM -1.58374418712511 0.0820599365540086 no 3083 0.0566259724752785 4517 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2235 salicylic acid 500 µM -1.58398581579637 0.0820263565507445 no 3084 0.0565984734810501 4606 338 A COX inhibitor and kinase inhibitor.
SGTC_335 4077-0256 27.6 µM -1.58503908023434 0.0818801015317949 no 3085 0.0564787276650226 4473 3121989
SGTC_1114 scopoletin 1.73284 µM -1.59013817598083 0.0811748249828088 no 3086 0.0559018312158011 4569 5280460 A coumarin with genotoxic properties.
SGTC_1702 st027038 51 µM -1.59570191451765 0.0804105218032151 no 3087 0.0552776804978151 4572 5521182
SGTC_1361 1608-0041 5.61 µM -1.59723839266685 0.0802004134982318 no 3088 0.0551062888451978 4553 X1361
SGTC_1266 0828-0227 32.9 µM -1.59853230264853 0.0800237976689015 no 3089 0.0549622811568111 4518 3913820
SGTC_2568 diosmetin 100 µM -1.60357050613861 0.0793388951321863 no 3090 0.0544043781258366 4551 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1345 1488-0192 31.4 µM -1.60896656026761 0.0786102768078125 no 3091 0.0538118268966567 4584 658348
SGTC_2973 9094665 17.96 µM -1.61965374260095 0.0771821932827743 no 3092 0.0526533390343349 4534 25237061 YIL048W NEO1
SGTC_1987 st072290 61.9 µM -1.6214266243575 0.0769472088751012 no 3093 0.0524630873120776 4576 54697379
SGTC_1630 st005209 31.3 µM -1.64021082302017 0.0744907830941289 no 3094 0.0504806698706983 4555 3367314
SGTC_2977 9011197 71.43 µM -1.6413436381367 0.0743445802330704 no 3095 0.0503630512144642 4587 2704722
SGTC_3340 9146634 11.102 µM -1.64380464504233 0.0740277140793883 no 3096 0.05010828078924 4562 4907387
SGTC_2227 7312221 64.1025 µM -1.64544685986529 0.0738168459006032 no 3097 0.0499388463882572 4667 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2909 7941780 10.49 µM -1.64735921582421 0.0735718692269314 no 3098 0.0497421165332614 4520 1243215
SGTC_384 k007-0144 5.16 µM -1.65386640965921 0.0727429395336757 no 3099 0.0490773294802534 4535 6824886
SGTC_1317 1273-0028 910 nM -1.65873166844258 0.0721278569754816 no 3100 0.0485849374941957 4589 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_330 1488-0319 80.1 µM -1.65970308255329 0.0720055263476608 no 3101 0.0484870994753641 4588 6846614
SGTC_3226 9131256 49.47 µM -1.65976712724699 0.0719974667626797 no 3102 0.0484806546190849 4584 17178073
SGTC_3214 9129694 49.47 µM -1.6612903454817 0.0718059839887439 no 3103 0.0483275740420843 4557 17158655
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.66442191998925 0.0714135430395335 no 3104 0.0480140712947198 4574 803109
SGTC_2228 7354201 200 µM -1.6644261239472 0.0714130173188572 no 3105 0.0480136515320271 4668 753451
SGTC_2214 7179297 48.276 µM -1.66510537250266 0.0713281137502956 no 3106 0.0479458675357311 4635 769744
SGTC_1925 st057770 10.1 µM -1.66708253558357 0.0710814166568697 no 3107 0.0477489971576188 4573 5989122
SGTC_2946 9065502 71.43 µM -1.6693840436062 0.070795075865917 no 3108 0.0475206469257281 4451 16489101
SGTC_279 1273-0055 2.93 µM -1.67014829023938 0.070700188825854 no 3109 0.0474450139375489 4621 2847562
SGTC_2185 6113692 200 µM -1.67207494682168 0.0704614134949474 no 3110 0.047254772086657 4568 874150
SGTC_2389 9091542 195.52 µM -1.67264202113478 0.0703912527883688 no 3111 0.0471988946645754 4548 3626624 YOL127W RPL25
SGTC_663 1486-0733 13.9 µM -1.67487929030863 0.0701149727856055 no 3112 0.0469789588485416 4592 722445 YPR165W RHO1
SGTC_3086 9117350 49.47 µM -1.67738896412391 0.0698060470902274 no 3113 0.0467332229920236 4563 2679265
SGTC_2055 5235184 200 µM -1.68028407805607 0.0694509785367653 no 3114 0.0464510286996789 4580 2836034
SGTC_3160 9100216 49.47 µM -1.69280315164886 0.0679315806043782 no 3115 0.0452464712983467 4586 17191039
SGTC_1199 1638-0010 4.46 µM -1.69457700039064 0.067718386719273 no 3116 0.0450778465924716 4568 3111136
SGTC_1754 st042065 16.137 µM -1.69596438820434 0.0675520009901745 no 3117 0.0449463122152779 4331 1126236 YIL048W NEO1
SGTC_525 k781-2675 26.7 µM -1.69755608277403 0.0673615025906031 no 3118 0.0447957888216397 4533 3651118 YDL195W SEC31
SGTC_598 3937-0236 20.2 µM -1.69873529939025 0.0672206386676578 no 3119 0.0446845346081611 4635 1379313
SGTC_1968 st069590 43.6 µM -1.70626727853989 0.0663262692666372 no 3120 0.0439791637132765 4559 6384066
SGTC_1043 0916-0009 19.3 µM -1.70814648219827 0.0661045698368955 no 3121 0.0438045829498148 4596 3101130
SGTC_2671 danthron 100 µM -1.71528171825702 0.06526801379403 no 3122 0.0431467943555641 4587 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_351 caspofungin 25 nM -1.71620463020871 0.0651604114553252 no 3123 0.043062298029731 4594 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3336 9143619 71.43 µM -1.71632838426101 0.0651459934384417 no 3124 0.0430509780163725 4596 45595730
SGTC_1634 st006576 41 µM -1.71639057862169 0.0651387483935854 no 3125 0.043045289890261 4572 3915356
SGTC_917 harmaline 728.087 nM -1.71736519365537 0.0650252967673382 no 3126 0.042956233545048 4516 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_63 0099-0242 26.702 µM -1.72112320039406 0.0645892752856639 no 3127 0.0426142350672054 4611 3898502 YLR359W ADE13
SGTC_462 ag-879 158 µM -1.72527165461527 0.0641105931391767 no 3128 0.0422392638537376 4600 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_544 k015-0020 52.4 µM -1.72579476776658 0.0640504284443458 no 3129 0.0421921707369928 4632 3008304
SGTC_1640 st009078 66.4 µM -1.7307006256576 0.0634883263909353 no 3130 0.0417525868066614 4579 690618
SGTC_2506 ethyl hematommate 54.16 µM -1.73432441290256 0.0630755920486708 no 3131 0.0414302691065436 4610 3940691 An allergen.
SGTC_3341 9147222 25.867 µM -1.73528465516619 0.0629665754327435 no 3132 0.0413451991642271 4599 1939759
SGTC_1919 st067113 52.3 µM -1.75141371169537 0.0611572953194317 no 3133 0.0399373364035187 4569 1268243
SGTC_475 α-linolenic acid 10 µM -1.75296112565008 0.0609858719015815 no 3134 0.0398043400516211 4603 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3354 9151612 71.43 µM -1.75393812176826 0.0608778332990391 no 3135 0.0397205552658726 4589 27261949
SGTC_3048 9093155 49.47 µM -1.75535266754425 0.0607216746501071 no 3136 0.039599501455352 4605 25236002
SGTC_1828 st055811 49 µM -1.75682669642435 0.0605592828713567 no 3137 0.0394736766085096 4608 5877589
SGTC_1201 1889-3372 45.9 µM -1.75770433846843 0.0604627557199162 no 3138 0.0393989146409755 4516 5392199
SGTC_119 0121-0043 24.815 µM -1.75927814208825 0.060289963031272 no 3139 0.0392651386599185 4617 1092378
SGTC_2841 9004761 38.96 µM -1.76548794707436 0.0596119384085157 no 3140 0.0387408970719156 4555 2991039
SGTC_978 1416-0512 87.4 µM -1.76747938905185 0.0593957705496117 no 3141 0.038573988897141 4634 6814003
SGTC_827 3253-0474 693 µM -1.76769886145756 0.0593719848120361 no 3142 0.0385556302201464 4627 5402065
SGTC_718 1130-0073 349 µM -1.76988436049694 0.0591355344602015 no 3143 0.0383732033313075 4619 6740020
SGTC_3342 9147791 14.508 µM -1.76996609990058 0.0591267053777884 no 3144 0.0383663940948745 4576 1838168
SGTC_2877 9040724 71.43 µM -1.77541657492913 0.0585403018576599 no 3145 0.0379145646045238 4575 6463895
SGTC_2669 eugenol 100 µM -1.77813801002476 0.058249223354964 no 3146 0.0376905955287548 4653 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2827 7993847 71.43 µM -1.779053632621 0.0581515464675829 no 3147 0.0376154847359057 4643 2985692
SGTC_2670 beta-carotene 100 µM -1.78045907072607 0.0580018674158172 no 3148 0.0375004309570534 4617 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2213 7173844 200 µM -1.78069989262625 0.057976250314819 no 3149 0.0374807453554851 4637 892728
SGTC_20 0481-0013 4.944 µM -1.7824293021583 0.0577925478692811 no 3150 0.0373396253193036 4671 182045
SGTC_2916 7875993 68.79 µM -1.78577533166038 0.0574384233207033 no 3151 0.0370678212032753 4535 1299250
SGTC_584 0986-0246 15.4 µM -1.789237266469 0.0570738311199778 no 3152 0.0367883061683363 4676 53315 YDR232W HEM1
SGTC_2212 7123476 200 µM -1.79270812146521 0.0567101308563692 no 3153 0.0365098036174179 4668 1085715
SGTC_2545 solidagenone 89.61 µM -1.79631506250624 0.0563341075939474 no 3154 0.0362222118275046 4588 6708572 An anti ulcer agent
SGTC_2533 agelasine 13.65 µM -1.80296948081964 0.0556455454331926 no 3155 0.0356965039116754 4637 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_430 0958-0115 16.4 µM -1.80709002986246 0.0552225151302292 no 3156 0.0353741214687336 4559 6833180
SGTC_2428 5615643 7.78 µM -1.80999542113708 0.0549257672367994 no 3157 0.0351482486208887 4629 2253075
SGTC_432 NS 1619 61.3 µM -1.81959010414383 0.0539547400494508 no 3158 0.0344107249020703 4583 4552 A K+/calcium channel activator.
SGTC_1958 st076513 41.9 µM -1.82383384053253 0.0535296118569265 no 3159 0.034088598076731 4567 732122 YGL099W LSG1
SGTC_1334 1486-0610 236 µM -1.82427966210295 0.0534851049102835 no 3160 0.0340549017519085 4677 3742339
SGTC_2676 harmalol 100 µM -1.82671713269153 0.0532422872188651 no 3161 0.0338711554556774 4620 5459187 A monoamine oxidase inhibitor
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.82944849073397 0.0529712319658594 no 3162 0.0336662245191362 4618 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_304 1310-0298 97 µM -1.83088292098959 0.0528293205225194 no 3163 0.0335590100269595 4384 1550234
SGTC_2317 5986382 200 µM -1.83244564862131 0.0526750597745137 no 3164 0.0334425261654481 4653 877883
SGTC_2297 7971671 152.32 µM -1.83325793631024 0.0525950181256961 no 3165 0.0333821108125788 4619 909016
SGTC_2325 6158266 200 µM -1.83651842176567 0.0522747055415071 no 3166 0.033140510061128 4604 3623240
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.85277995122029 0.0507002264242504 no 3167 0.031956952492439 4658 5024745
SGTC_2461 5755302 26.15 µM -1.85344019329336 0.0506371069469576 no 3168 0.0319096454304613 4633 2788904
SGTC_1872 amphotericin b 148 nM -1.85477602758239 0.0505095919396827 no 3169 0.0318141083435525 4661 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1415 3966-0071 78.1 µM -1.85725687496757 0.0502734559976762 no 3170 0.0316373083650852 4566 2893185
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.85746289740949 0.0502538856782603 no 3171 0.0316226625636648 4620 756377
SGTC_3039 9090270 49.47 µM -1.8650083563161 0.0495413077238477 no 3172 0.0310901164591573 4642 17173750
SGTC_3261 9137475 49.47 µM -1.86884588943554 0.049182004940971 no 3173 0.0308221291640316 4682 17027690
SGTC_862 0452-0056 10.2 µM -1.87013155011743 0.0490620968220456 no 3174 0.0307327760925845 4619 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3073 9114972 49.47 µM -1.87464842323611 0.0486426776300096 no 3175 0.0304205533937805 4656 41905075
SGTC_792 4534-1957 155 µM -1.87663570022655 0.0484590571259304 no 3176 0.0302840204484224 4612 1717904
SGTC_1818 st052136 56.3 µM -1.87681775995334 0.0484422629176235 no 3177 0.0302715377362232 4332 674169
SGTC_885 0865-0106 16.8 µM -1.87853381598626 0.0482841929129777 no 3178 0.0301540877578379 4625 2793380
SGTC_3017 9080681 49.47 µM -1.88135229990421 0.0480254712768058 no 3179 0.0299620054903708 4672 16451914
SGTC_1739 st037196 92.5 µM -1.88679990227747 0.0475285561207675 no 3180 0.0295936221427062 4655 612214
SGTC_281 1672-3440 14.9 µM -1.89246826894935 0.047015884718726 no 3181 0.0292143087678888 4680 6833000
SGTC_2257 7960413 200 µM -1.89835517630134 0.0464881512303849 no 3182 0.0288246550341674 4691 2974689 YIL048W NEO1
SGTC_627 1391-0720 175 µM -1.90080988165023 0.0462695077885677 no 3183 0.0286634596425486 4657 997839
SGTC_2277 7947813 106.88 µM -1.90173447301324 0.0461873677558491 no 3184 0.0286029383356024 4659 1246798
SGTC_642 0335-0876 158 µM -1.91154516221799 0.0453229881465376 no 3185 0.027967279407081 4699 6812350
SGTC_421 streptovitacin 30 mM -1.91507019950411 0.0450156076774349 no 3186 0.0277417758357118 4636 91467 include heat shock
SGTC_353 1988-1175 58.3 µM -1.91890619007609 0.0446830210635288 no 3187 0.0274981035538165 4509 2788357
SGTC_2210 7115885 190.385 µM -1.92009674844873 0.0445802010791498 no 3188 0.027422839971981 4727 2927039
SGTC_2702 st077768 96.8 µM -1.92119396312551 0.0444856113597551 no 3189 0.0273536294816251 4638 6484119
SGTC_1969 st069479 40.1 µM -1.92701244062687 0.0439867056417635 no 3190 0.0269890397780314 4662 3895485
SGTC_875 0709-0210 25.7 µM -1.92997621682466 0.0437343165018174 no 3191 0.0268048923362494 4658 6251364
SGTC_1967 st070177 51.4 µM -1.93362522946079 0.0434251802834151 no 3192 0.0265796114820237 4674 5729214
SGTC_1654 st012436 41.8 µM -1.93498486239297 0.0433104472820334 no 3193 0.0264960766485591 4687 4323132
SGTC_1356 1502-0781 85.8 µM -1.94295152814338 0.0426430882358587 no 3194 0.0260110075909643 4685 567702
SGTC_1121 fusaric acid 630.51 nM -1.94319989147192 0.0426224174976836 no 3195 0.0259960056052184 4649 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3180 9109287 49.47 µM -1.94694831602617 0.0423114270083045 no 3196 0.0257704656397817 4687 18891271
SGTC_1696 st025591 34.7925 µM -1.94866610254418 0.0421695244167682 no 3197 0.0256676561994391 4653 2787147
SGTC_2696 st077691 74.316 µM -1.95385725299175 0.0417430339386673 no 3198 0.0253590505738065 4669 757133
SGTC_2182 6325192 200 µM -1.95882445409053 0.0413382196813916 no 3199 0.0250666743510662 4687 736248
SGTC_1150 3909-7983 10.9 µM -1.96095742471616 0.0411653673351854 no 3200 0.0249419948185783 4674 23965914
SGTC_759 3486-0358 89.3 µM -1.96600196147829 0.0407588978917663 no 3201 0.024649192017368 4652 875103
SGTC_3284 9108171 64.8615 µM -1.96784563681461 0.0406111566814187 no 3202 0.0245429007021859 4644 8687505
SGTC_2184 6075246 200 µM -1.96885125489605 0.0405307557928859 no 3203 0.0244850872535706 4672 2267320
SGTC_2930 9013230 14.89 µM -1.96954342695705 0.0404754905670975 no 3204 0.0244453604144257 4625 2995857
SGTC_3244 9134489 49.47 µM -1.97198336452699 0.0402811659291187 no 3205 0.0243057528000571 4676 16584271
SGTC_372 0155-0182 15.9 µM -1.9736849119249 0.0401460981013263 no 3206 0.0242087909214398 4567 771486
SGTC_928 2764-0428 58.7 µM -1.97412300730333 0.0401113819746656 no 3207 0.0241838789189586 4695 662578
SGTC_2551 apiole 73.87 µM -1.9824940744022 0.0394527039210944 no 3208 0.0237119849685588 4635 10659 A possible DNA adduct former.
SGTC_847 0342-0274 5.54 µM -1.98295496441683 0.0394166958406241 no 3209 0.023686230126067 4675 18097
SGTC_1224 0823-0416 294 µM -1.98522401588438 0.0392398106819161 no 3210 0.0235597767449215 4692 3598164
SGTC_865 0488-0499 301 µM -1.98900574431661 0.0389464399285674 no 3211 0.0233502844643407 4636 9634651
SGTC_3009 9080819 71.4286 µM -1.99134020271995 0.0387662356303579 no 3212 0.023221749224999 4695 17027216
SGTC_1416 3966-0321 25.3 µM -1.99282900327286 0.0386516654836477 no 3213 0.023140087346878 4726 582530 YLR208W SEC13
SGTC_2997 9067075 71.4286 µM -1.99428523714478 0.0385398685420162 no 3214 0.0230604458259938 4649 27209819
SGTC_764 1951-2361 146 µM -1.99919903743682 0.0381645732336593 no 3215 0.0227934113423997 4688 5438930
SGTC_1874 staurosporine 7.6 µM -1.99985700984216 0.0381145471137125 no 3216 0.0227578532289909 4678 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1547 harmine 94.2 µM -2.00415898441939 0.0377887814443114 no 3217 0.022526516308917 4607 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2179 6298986 200 µM -2.00980262883534 0.0373648679993496 no 3218 0.0222260412310414 4653 738374
SGTC_2493 resveratrol 26.09 µM -2.01335257922114 0.0371002149021799 no 3219 0.0220387752912534 4663 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_503 tyrphostin 8 294 µM -2.017951183299 0.0367596631247106 no 3220 0.0217981728409946 4696 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_846 0335-0850 148 µM -2.0297363195161 0.0358985685417381 no 3221 0.0211916745007551 4685 6819598
SGTC_1200 1643-0193 18.4 µM -2.03481819741542 0.035532389256617 no 3222 0.0209345846738469 4707 5403974
SGTC_654 1124-0271 80.9 µM -2.0440057777748 0.0348781446200445 no 3223 0.0204764881830076 4701 5403748
SGTC_2462 5162487 171.77 µM -2.05887971004816 0.0338399640006466 no 3224 0.0197528816197212 4681 2259986
SGTC_2570 licareol 100 µM -2.06406201416781 0.0334842723548223 no 3225 0.019505918480237 4662 443158
SGTC_3183 9108214 49.47 µM -2.06698432038068 0.0332850583971595 no 3226 0.0193678157218218 4726 4974831
SGTC_2086 5274770 176.623 µM -2.08168910630704 0.0322973919673374 no 3227 0.0186854381584126 4712 689278
SGTC_623 k072-0108 16.9 µM -2.08498826249733 0.0320791542609628 no 3228 0.0185351829918052 4692 5382803
SGTC_1305 1181-0477 144 µM -2.08598606861684 0.0320133901399063 no 3229 0.0184899425129801 4717 6252086
SGTC_1019 4262-0212 3.4 µM -2.08638863336293 0.0319868891510183 no 3230 0.0184717168874223 4673 4677213
SGTC_2060 5238662 140 µM -2.09893702865622 0.0311698641730201 no 3231 0.0179112260772618 4678 790130
SGTC_2550 chrysin dimethyl ether 71.87 µM -2.10303983094028 0.0309065054188439 no 3232 0.0177311439204557 4634 88881 An O-methylated flavonoid and antioxidant.
SGTC_19 0279-0214 38.434 µM -2.10378904061491 0.0308586130954275 no 3233 0.0176984266107603 4750 3566274 YBR002C RER2
SGTC_1216 1165-0504 9.65 µM -2.10822934271149 0.0305760314920569 no 3234 0.0175055781652307 4728 6304004
SGTC_299 1273-0059 1.44 µM -2.11672834361809 0.0300411301880716 no 3235 0.0171414549361375 4479 2848077
SGTC_1100 amiodarone 5.07 µM -2.12431421579822 0.0295702740513665 no 3236 0.0168219388966203 4715 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_813 k007-0158 173 µM -2.12653254331296 0.0294337453866726 no 3237 0.0167294712574933 4701 6523916
SGTC_2935 9038016 29.96 µM -2.14491792123906 0.028322227433888 no 3238 0.0159797050461328 4669 6463195
SGTC_4 0960-0234 25.671 µM -2.14559593644272 0.0282819141019269 no 3239 0.0159526149663177 4662 6821112
SGTC_547 1120-0019 610 nM -2.14808789694171 0.0281341575905658 no 3240 0.0158533867590223 4702 3676939
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -2.15102942506843 0.0279605723883857 no 3241 0.0157369386159752 4717 616764
SGTC_1561 5-methoxyflavone 52.9 µM -2.1544791721762 0.0277581336636372 no 3242 0.0156013068054261 4703 94525
SGTC_2549 cedrol 20.94 µM -2.156905307759 0.0276164953947613 no 3243 0.0155065216489405 4695 6708665 A sedative which affects the nervous system.
SGTC_1086 cerivastatin 2.18 µM -2.16001711451137 0.0274357098328652 no 3244 0.0153856723472401 4728 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2186 6124449 200 µM -2.1677100389706 0.0269930083739369 no 3245 0.0150903775879599 4722 3834182 YLR033W RSC58
SGTC_2611 pyromycin 23.93 µM -2.16870035624032 0.0269364545881413 no 3246 0.0150527201648857 4672 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2206 7254556 146.969 µM -2.18269180738298 0.0261479631768918 no 3247 0.0145292568298292 4740 4398905
SGTC_1129 3453-1384 223 µM -2.19536511473905 0.0254505050238578 no 3248 0.014068708722352 4684 1084452
SGTC_3136 9095672 49.47 µM -2.19848102336303 0.0252814320847601 no 3249 0.0139574227060319 4639 17217380
SGTC_3176 9106582 49.47 µM -2.20048012603522 0.0251734547173539 no 3250 0.0138864242307746 4757 17018027
SGTC_44 0929-0055 61.211 µM -2.20304284394525 0.0250356003886877 no 3251 0.0137958645255683 4572 1379590
SGTC_1053 3366-3204 134 µM -2.20624095531621 0.0248644550288506 no 3252 0.0136835665452205 4720 3632071 YPR165W RHO1
SGTC_2038 4100038 30.985 µM -2.21360914957248 0.0244738812731559 no 3253 0.0134278386868127 4698 3596803
SGTC_27 0485-0001 32.618 µM -2.21417751876295 0.0244439682557274 no 3254 0.0134082848629253 4754 2054479
SGTC_1404 3909-7820 48.3 µM -2.22088670436107 0.0240931802762406 no 3255 0.0131793179902099 4724 23741373
SGTC_2230 bromochlorosalicylanilide 954.5 nM -2.22506838093749 0.0238766892277846 no 3256 0.0130383239951784 4762 77254
SGTC_3042 9091578 49.47 µM -2.22796670271525 0.0237276005024008 no 3257 0.0129413677475827 4723 25236497
SGTC_2205 7238770 200 µM -2.23048485561818 0.0235987037518442 no 3258 0.0128576358779691 4737 279867
SGTC_3236 9132701 49.47 µM -2.23299961902526 0.0234705687500196 no 3259 0.0127744847464129 4740 24282524
SGTC_1873 rapamycin 2 nM -2.23495236593701 0.0233714744202959 no 3260 0.0127102380653163 4719 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2547 epiafzelechin trimethyl ether 100 µM -2.23775111139575 0.0232300630364246 no 3261 0.0126186450727399 4721 6708630 An antioxidant.
SGTC_2207 7258803 200 µM -2.23946070551215 0.0231440377526228 no 3262 0.0125629776552719 4745 3666799
SGTC_2309 7664088 163.95 µM -2.24912749093218 0.022662644415992 no 3263 0.0122521929861831 4705 704922
SGTC_1382 3002-2117 298 µM -2.25006644408631 0.022616338767035 no 3264 0.0122223639005129 4749 1497314
SGTC_1644 st010134 20.9 µM -2.25145579463334 0.0225479675497287 no 3265 0.0121783418493931 4723 3818134
SGTC_1434 4073-0095 163 µM -2.26131060270002 0.0220679883192973 no 3266 0.0118700150688823 4749 24133745
SGTC_1618 st003135 44.5 µM -2.26940945514412 0.0216800161060008 no 3267 0.0116217188695286 4730 1270615
SGTC_2273 7815444 169.05 µM -2.27071730360845 0.0216179078005182 no 3268 0.0115820484201675 4685 2824616
SGTC_1292 0kpi-0043 232 µM -2.27498358711319 0.0214163507999669 no 3269 0.0114534572168223 4742 3333905
SGTC_994 3910-0338 138 µM -2.28103106611286 0.0211333665259821 no 3270 0.0112733043175972 4741 3479481
SGTC_2523 spermine 47.74 µM -2.28166492326267 0.0211038899644237 no 3271 0.0112545652445065 4729 1103 A DNA binding polyamine.
SGTC_1041 0206-0046 107 µM -2.29618479417859 0.0204381301180112 no 3272 0.0108326587980035 4730 50494
SGTC_2488 5268135 45.7 µM -2.2969925626894 0.0204016211821607 no 3273 0.0108095970036315 4733 1270356 YLR208W SEC13
SGTC_2582 agaric acid 100 µM -2.29704620314994 0.0203991987377466 no 3274 0.0108080670826488 4456 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2541 muurolladie-3-one 83.07 µM -2.30688814224918 0.0199588357410684 no 3275 0.0105305283726233 4705 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2770 toltrazuril 17.5 µM -2.30942989050587 0.0198464283150235 no 3276 0.0104598689816646 4703 68591 Kills coccidiodes.
SGTC_857 0438-0306 1.35 µM -2.31658480309803 0.0195328871279104 no 3277 0.0102631799960724 4760 4686136
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.34334828120331 0.0183971010943059 no 3278 0.00955576670115127 4722 17037758
SGTC_2700 st077718 96.8 µM -2.36714373834622 0.0174349955153201 no 3279 0.00896298463361235 4726 904970
SGTC_3025 9087895 49.47 µM -2.36819433035959 0.0173935269680089 no 3280 0.00893757210113346 4748 17173641
SGTC_150 3970-0969 77.2 µM -2.38680360696854 0.0166728314378571 no 3281 0.00849778383308412 4746 6615640
SGTC_2231 micatex 6.853 µM -2.39363784120999 0.0164146487643134 no 3282 0.00834110582551663 4754 20737 An antifungal of unknown mechanism.
SGTC_142 0335-0849 62.6745 µM -2.3950079118819 0.0163633044180903 no 3283 0.00831000331869282 4707 3889043 YPR107C YTH1
SGTC_2272 7805186 180 µM -2.39775467376908 0.0162607817624886 no 3284 0.00824795463432201 4740 2956062 YPR165W RHO1
SGTC_2608 thymoquinone 42.66 µM -2.41644882205268 0.0155775340460037 no 3285 0.00783636464230934 4710 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_327 1273-0057 3.96 µM -2.41759509948749 0.0155364528322117 no 3286 0.00781172543147948 4720 3108138
SGTC_457 grayanotoxin iii 135 µM -2.42016462493011 0.0154447018228172 no 3287 0.00775674103659631 4602 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2788 5282734 71.43 µM -2.43276821083946 0.0150013680147658 no 3288 0.00749194474299992 4742 743706
SGTC_775 4577-0580 57.3 µM -2.44035382609684 0.014739850445925 no 3289 0.00733644135669748 4742 2006902
SGTC_868 0527-0199 213 µM -2.44135841223473 0.0147055126763129 no 3290 0.00731606239028722 4749 2849450
SGTC_406 estrone 100 µM -2.44820025140441 0.0144734769798263 no 3291 0.00717859179492708 4743 5870 A steroid.
SGTC_2965 9082772 38.63 µM -2.45111297014426 0.0143756549443597 no 3292 0.00712076243071184 4739 16459634
SGTC_2753 fluvastatin 17.09 µM -2.45231051797245 0.0143356014210717 no 3293 0.00709710569702813 4730 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2667 digitoxin 100 µM -2.45910763264424 0.0141100792634631 no 3294 0.00696414266864328 4768 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2435 5706476 10.6 µM -2.46141990223884 0.0140340603347112 no 3295 0.00691941472161502 4751 5725375
SGTC_2886 9058944 51.95 µM -2.46792073191807 0.0138222254677406 no 3296 0.00679502051517411 4775 4949929
SGTC_3230 9131665 49.47 µM -2.48016157362111 0.0134308252911376 no 3297 0.00656614301085582 4778 15943720
SGTC_635 k038-0028 24.7 µM -2.48528096381483 0.0132699930699118 no 3298 0.00647246108612548 4767 4035102
SGTC_936 3005-4620 401 µM -2.48617467142918 0.0132420873371624 no 3299 0.0064562285291416 4757 777207
SGTC_2208 7283366 200 µM -2.52234681020407 0.0121543831725817 no 3300 0.00582873564233929 4755 898663
SGTC_1984 st072354 53.1 µM -2.53804079446358 0.0117070931793217 no 3301 0.00557374947102885 4722 5762938
SGTC_2311 7694451 200 µM -2.54377601350736 0.0115472372451101 no 3302 0.00548306896472814 4761 2163142
SGTC_171 k064-0041 9.68 µM -2.54539543922676 0.0115024441068009 no 3303 0.00545770243248874 4734 53325
SGTC_1238 0333-0287 48.8 µM -2.56262255788503 0.0110352090708036 no 3304 0.00519424577564094 4781 7226
SGTC_1031 k035-0009 16 µM -2.56356495165542 0.0110101326236052 no 3305 0.00518016570908738 4771 5180959
SGTC_985 1493-0307 8.71 µM -2.56958132191172 0.0108512065933924 no 3306 0.0050910745175415 4773 3278274
SGTC_2226 7298446 200 µM -2.57179780929048 0.0107931620758771 no 3307 0.00505859793951383 4766 3283010
SGTC_173 1273-0061 2.693 µM -2.59013234523779 0.0103233019733122 no 3308 0.00479695201266514 4732 2847414 YPL266W DIM1
SGTC_2627 acetyl isogambogic acid 100 µM -2.59016072229355 0.0103225888000465 no 3309 0.00479655658489726 4740 6857789 A caspase activator and apoptosis inducer.
SGTC_2659 sanguinarine 24.21 µM -2.61642010729542 0.00968077374353607 no 3310 0.00444285779449132 4758 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2316 5844804 197.44 µM -2.62043573137303 0.00958576498868069 no 3311 0.00439087404978542 4763 776813
SGTC_3064 1327-0027 10 µM -2.63504223263654 0.00924701866177399 no 3312 0.00420634075983582 4763 16000455 YPR107C YTH1
SGTC_2083 5306046 65.942 µM -2.66657205329298 0.00855131399674679 no 3313 0.00383145891630154 4781 539837
SGTC_514 4466-0038 2.65 nM -2.67480899191071 0.00837730920042862 no 3314 0.00373859186667583 4662 5722064
SGTC_3037 9091026 49.47 µM -2.70294384868987 0.00780618303210668 no 3315 0.00343641778841428 4698 25236398 YIL048W NEO1
SGTC_987 1497-1013 404 µM -2.72362243800412 0.00740854020016607 no 3316 0.00322851383430504 4781 1676435
SGTC_2955 9076254 12.21 µM -2.7337254630111 0.00722083540272902 no 3317 0.00313111168480508 4762 16459619
SGTC_1698 5-fluorocytosine 1.055 µM -2.75701032654401 0.00680411395455266 no 3318 0.00291662546508516 4783 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1360 1598-0022 39.8 µM -2.78910135802238 0.00626465307458286 no 3319 0.0026427260287083 4792 761525
SGTC_2215 7188065 200 µM -2.79976438797479 0.0060939796022904 no 3320 0.0025569959212988 4784 940217
SGTC_138 0850-0259 40.9225 µM -2.8129806088817 0.00588816620636063 no 3321 0.0024542305524744 4736 6813004
SGTC_2211 7117706 200 µM -2.81696500029462 0.00582733952264553 no 3322 0.00242399041910432 4772 822771
SGTC_2546 rhodinyl acetate 100 µM -2.8503238401139 0.00533955999672497 no 3323 0.00218373680417654 4784 6708682
SGTC_3040 9091894 49.47 µM -2.86106947363182 0.0051903554349995 no 3324 0.00211107259469506 4763 25236966
SGTC_2899 9053889 58.44 µM -2.89044565167023 0.0048012241541 no 3325 0.0019234802142399 4795 6470052
SGTC_826 1683-5028 118 µM -2.89325255441133 0.00476543973465082 no 3326 0.00190637291559941 4795 722377
SGTC_160 3453-0671 289.699 µM -2.90080672121504 0.00467031231470787 no 3327 0.00186101687949902 4758 5322268
SGTC_1972 st070201 17.4 µM -2.90698285061934 0.00459380081082942 no 3328 0.00182466601958438 4794 2829099
SGTC_1058 3448-5425 97.3 µM -2.92811691836796 0.0043403800932351 no 3329 0.00170510890531615 4781 7279705
SGTC_2994 9053520 71.4286 µM -2.94497687438019 0.00414724988640833 no 3330 0.00161489401088443 4777 4647384
SGTC_1957 st077035 62.4 µM -2.97198131940712 0.00385389860582591 no 3331 0.00147942343183385 4784 705593
SGTC_2229 7354935 190 µM -2.98178213612759 0.00375212065899757 no 3332 0.00143287927266325 4781 318112
SGTC_2519 cryptotanshinone 88.04 µM -2.99449608381887 0.00362368476504315 no 3333 0.00137449292370234 4785 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1852 st056254 31.4 µM -3.01081392485222 0.00346462961010769 no 3334 0.00130274232558768 4785 442583
SGTC_1145 3546-0597 10.2 µM -3.03843159546992 0.00320967074911712 no 3335 0.00118906544210936 4789 875334
SGTC_1707 st032323 6.317 µM -3.0632829109287 0.00299481618716123 no 3336 0.0010946149118192 4706 3132057 YMR211W DML1
SGTC_2526 patulin 37.61 µM -3.11657792168604 0.00257714597127302 no 3337 0.000914816601894332 4784 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_429 1112-0049 25.5 µM -3.25037790570935 0.00175045004148999 no 3338 0.000576258724253439 4779 2836170
SGTC_1049 3226-0134 66 µM -3.25070582724721 0.00174876144901327 no 3339 0.000575594526489956 4790 5702385
SGTC_2092 5303694 80.6725 µM -3.25711175422918 0.00171607081922572 no 3340 0.000562760556218752 4801 1963699
SGTC_649 1123-0311 367 µM -3.29246169521847 0.00154546985874956 no 3341 0.000496572127583529 4769 693629 YIL048W NEO1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -3.30563875466436 0.00148593905995038 no 3342 0.000473800862122089 4804 4000243
SGTC_1844 rapamycin 4 nM -3.47168388321301 0.000895317566410481 yes 3343 0.000258602490074953 4724 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2430 5571206 200 µM -3.61590041633807 0.000566568708954259 yes 3344 0.000149652714829262 4788 1731771
SGTC_58 0957-0393 9 µM -3.66930783439514 0.000476271405853355 yes 3345 0.000121604038440043 4574 6997992
SGTC_984 1492-0255 2.91 µM -3.68619416199274 0.000450621411988119 yes 3346 0.000113816353476579 4803 1585198
SGTC_2898 9056270 58.44 µM -3.74898720345465 0.000366057397188818 yes 3347 8.8775071833117e-05 4807 19154699
SGTC_2616 abietic acid 100 µM -4.10620137383298 0.000105741162618946 yes 3348 2.01109433392725e-05 4805 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1916 st067606 49.2 µM -4.41244574200257 3.3630712626421e-05 yes 3349 5.11047068942945e-06 4799 19590279
SGTC_1780 st038448 24.544 µM -4.44360226069992 2.98053183927664e-05 yes 3350 4.42325396946966e-06 4808 728868 YDL195W SEC31
SGTC_310 1273-0058 1.06 µM -4.50583836773964 2.33628604803773e-05 yes 3351 3.30556988903662e-06 4667 2734232
SGTC_3152 9099253 49.47 µM -4.98113909753598 3.28190257132997e-06 yes 3352 3.16055410953573e-07 4790 25236131
SGTC_2878 9043973 25.97 µM -5.78790399587185 7.71677474649716e-08 yes 3353 3.56350612719867e-09 4802 6465167
SGTC_2620 irigenin 100 µM -6.25482156045943 6.91189780076448e-09 yes 3354 1.98985335558581e-10 4805 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2874 9043904 71.43 µM -6.83735739263454 2.65182447639684e-10 yes 3355 4.03336610194179e-12 4805 4463428
SGTC_137 0438-0332 85.389 µM -6.94820049302467 1.38163841736853e-10 yes 3356 1.84987482687008e-12 4805 2063393 YER012W | YPR107C PRE1 | YTH1