SGTCid condition conc unit ENV9|YOR246C.score ENV9|YOR246C.strain.pval ENV9|YOR246C.strain.significant ENV9|YOR246C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2413 inermin 26.06 µM 41.9030385414113 0 yes 1 0 1 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_103 0844-0104 51.839 µM 27.7121263083683 1.30109974682605e-153 yes 2 2.49378563475694e-169 1 5375804 SGTC_2967 9089538 49.85 µM 24.496119625957 1.56150356142857e-120 yes 3 8.12354093047403e-133 1 728216 SGTC_733 4069-0007 56.1 µM 23.6370976732643 2.19766129507879e-112 yes 4 8.01103916751447e-124 2 5717425 YNL287W SEC21 SGTC_86 0417-1630 471.922 µM 18.6297709435692 1.18912286237717e-70 yes 5 9.21556879835426e-78 6 3634867 SGTC_142 0335-0849 62.6745 µM 18.3658931155456 1.00382376512447e-68 yes 6 1.23181680596326e-75 8 3889043 YPR107C YTH1 SGTC_805 3852-0218 479 µM 15.9262255875196 3.30832579829974e-52 yes 7 2.08383402221169e-57 1 6615355 SGTC_1161 k007-0610 110 µM 15.1776370671613 1.31955771858126e-47 yes 8 2.48689475481393e-52 6 5843850 SGTC_1789 tunicamycin 25 nM 13.6581038018892 6.09362556922613e-39 yes 9 9.03130651984846e-43 1 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_209 4077-0173 175.592 µM 12.5920958886872 2.10982153908429e-33 yes 10 1.1669643707837e-36 1 15993494 SGTC_165 k038-0023 64.381 µM 12.4163923202582 1.5654159295291e-32 yes 11 1.06474839462671e-35 3 46368543 SGTC_141 0443-0274 32.331 µM 11.1919669261385 8.42054015260185e-27 yes 12 2.23209599424275e-29 4 1627241 SGTC_352 k048-0007 5.11 µM 10.9999498830298 5.90162847717837e-26 yes 13 1.91172175526827e-28 6 6811911 SGTC_635 k038-0028 24.7 µM 10.3692715763457 2.80090730792151e-23 yes 14 1.71061335876329e-25 3 4035102 SGTC_2154 5570129 200 µM 10.2736415048583 6.91160044691047e-23 yes 15 4.63201767370552e-25 1 673366 SGTC_64 000l-0018 272.079 µM 9.72767409402951 1.02557869772442e-20 yes 16 1.14893445847311e-22 39 6811119 SGTC_1750 st081859 2.357 µM 9.69553308618835 1.36515643971534e-20 yes 17 1.57494209448859e-22 46 5291695 SGTC_2322 7413319 38.22 µM 9.55362646234826 4.77305471692325e-20 yes 18 6.26170274682102e-22 21 1840400 SGTC_200 k038-0079 37.545 µM 9.44932889664295 1.18398032171104e-19 yes 19 1.70504997227656e-21 9 3436683 SGTC_2385 9074692 200 µM 9.33933077293004 3.0540381067698e-19 yes 20 4.84724609444498e-21 3 17046906 SGTC_3090 9117696 49.47 µM 8.66799473116053 7.84517392867376e-17 yes 21 2.19898536830111e-18 1 7923821 SGTC_67 0335-0847 266 µM 8.2233744822234 2.47888970162704e-15 yes 22 9.89279109984628e-17 37 4552207 YOR254C SEC63 SGTC_137 0438-0332 85.389 µM 8.22317401374065 2.48265330260121e-15 yes 23 9.9093477897289e-17 34 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_143 4032-1194 15.74 µM 8.19466335541576 3.07937365547735e-15 yes 24 1.25647738563142e-16 8 1806963 SGTC_153 4077-0274 519.67 µM 8.18865932222265 3.22197431640712e-15 yes 25 1.32076043240235e-16 2 3121976 SGTC_167 3672-0051 66.205 µM 8.02520220996072 1.09139740737456e-14 yes 26 5.06794225541515e-16 6 3237971 SGTC_216 k038-0035 28.382 µM 7.47835388543558 5.43838826596059e-13 yes 27 3.7629656586284e-14 12 4444231 YPR107C YTH1 SGTC_1171 0368-0077 21.4 µM 7.3600097871664 1.22350997812449e-12 yes 28 9.19483726560909e-14 2 3239779 SGTC_384 k007-0144 5.16 µM 7.29099066695668 1.95199743479685e-12 yes 29 1.53842042210642e-13 16 6824886 SGTC_336 4111-0029 111 µM 7.10401377958342 6.77380569663501e-12 yes 30 6.05923828382718e-13 1 3131175 SGTC_72 0744-0168 198.391 µM 7.09106847816535 7.37470584050427e-12 yes 31 6.65402344799573e-13 4 677577 SGTC_3283 9109332 35.8195 µM 7.09044534127705 7.40491147916212e-12 yes 32 6.68405542267433e-13 1 17027281 SGTC_1601 4'-hydroxyflavanone 55.5 µM 7.01873319885816 1.18252545196523e-11 yes 33 1.11944417369855e-12 7 165506 SGTC_1240 0356-0016 42.1 µM 6.96177605788019 1.70946644813888e-11 yes 34 1.68004671134309e-12 7 4305613 SGTC_255 tunicamycin 200.472 nM 6.84101910354277 3.69873583374867e-11 yes 35 3.93158843395965e-12 22 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2210 7115885 190.385 µM 6.75227504223145 6.46851890278937e-11 yes 36 7.27723135155219e-12 7 2927039 SGTC_373 0844-0104 25.9 µM 6.73392450095156 7.25475534211514e-11 yes 37 8.25734472101064e-12 19 5375804 SGTC_2710 st078562 53.7235 µM 6.60952656741492 1.56646273946515e-10 yes 38 1.92775513265344e-11 1 17250908 SGTC_2604 4'-hydroxychalcone 11.32 µM 6.46541768564026 3.75616637819896e-10 yes 39 5.05096911005981e-11 5 5282362 SGTC_905 2-aminofluorene 215 µM 6.43273405654017 4.56854293241361e-10 yes 40 6.26644129502324e-11 5 1539 An established DNA mutagen. YPR165W RHO1 SGTC_367 0335-0881 7.1 µM 6.38768542401689 5.97458598287661e-10 yes 41 8.42076686762773e-11 22 23828853 SGTC_36 0335-0881 14.2 µM 6.31968438177078 8.92758206603268e-10 yes 42 1.31049027927186e-10 57 23828853 SGTC_1767 st044992 70.3 µM 6.12065049527308 2.82530094747783e-09 yes 43 4.65970579032879e-10 3 9600693 SGTC_1495 4469-0029 237 µM 6.04436810812401 4.35306891121386e-09 yes 44 7.49983486877718e-10 52 793680 SGTC_2371 9071574 200 µM 6.01160433760563 5.23290041020662e-09 yes 45 9.18481109384619e-10 1 45596039 SGTC_1647 st011722 22.4 µM 6.00823465194208 5.3326308217761e-09 yes 46 9.37771309817462e-10 1 2854783 SGTC_660 4031-1742 102 µM 5.96635151967732 6.73732738518332e-09 yes 47 1.2130865525587e-09 12 6738706 SGTC_1953 st076800 12.1 µM 5.71491992547104 2.6544324155563e-08 yes 48 5.48778471520406e-09 16 297591 SGTC_315 k915-0449 187 µM 5.66812562578435 3.40509831700786e-08 yes 49 7.21840514746275e-09 26 20970215 YNL149C PGA2 SGTC_642 0335-0876 158 µM 5.61820188506396 4.43198741431725e-08 yes 50 9.64774826488277e-09 15 6812350 SGTC_2580 diallyl disulphide 81.36 µM 5.57066285658234 5.6847956493828e-08 yes 51 1.26885989320493e-08 6 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1026 k007-1105 30.6 µM 5.53289842913249 6.91809177707569e-08 yes 52 1.57490944320274e-08 51 7066794 SGTC_1235 benzylparaben 21.5 µM 5.47362914482928 9.39113805182797e-08 yes 53 2.20455645527594e-08 2 7180 SGTC_942 3253-1115 227 µM 5.43815802454554 1.12593667762168e-07 yes 54 2.69171089956385e-08 7 46497897 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 5.3539029585376 1.7248689552109e-07 yes 55 4.30385178242067e-08 14 23847180 SGTC_1306 1185-0270 9.02 µM 5.26135193913228 2.7360321407763e-07 yes 56 7.15000084493917e-08 36 1548076 SGTC_848 0368-0089 85.6 µM 5.22492965780108 3.27399761887528e-07 yes 57 8.71106641291365e-08 3 762535 SGTC_2941 9056145 11.23 µM 5.22413421641468 3.28681504924238e-07 yes 58 8.74859180430773e-08 6 2119517 SGTC_1320 1313-0481 95.3 µM 5.11051800272465 5.71058118177783e-07 yes 59 1.60638346846965e-07 10 6813365 YLR208W SEC13 SGTC_340 k038-0059 454 µM 5.05038815515789 7.6148592070363e-07 yes 60 2.20456604679561e-07 29 23733424 SGTC_1119 parthenolide 318.541 nM 4.90542877929729 1.50425845599391e-06 yes 61 4.66117315983444e-07 21 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_639 0833-0042 114 µM 4.78637213590132 2.59534254003505e-06 yes 62 8.49115229095026e-07 27 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_696 1560-0013 611 µM 4.78576261904862 2.60251689802917e-06 yes 63 8.5169645182391e-07 11 1650269 SGTC_1427 4048-4900 550 nM 4.66227393529018 4.52260287862968e-06 yes 64 1.56367266396483e-06 17 24132586 SGTC_2469 5655019 90.81 µM 4.61880134285176 5.47651271014731e-06 yes 65 1.92981575684308e-06 15 2788239 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 4.55602310630422 7.19898714857059e-06 yes 66 2.60656021428624e-06 46 16725076 SGTC_2417 cerulenin 830 nM 4.53880195941264 7.7551718996415e-06 yes 67 2.8287368916095e-06 19 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3205 9113483 49.47 µM 4.53597077402323 7.85044348010424e-06 yes 68 2.86695603537637e-06 13 17018033 SGTC_410 α-linolenic acid 100 µM 4.53056337499821 8.03551580000086e-06 yes 69 2.94133021732047e-06 23 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1405 3909-7894 12 µM 4.52791151100958 8.1277906308539e-06 yes 70 2.9784757911101e-06 7 7104060 SGTC_3202 9113761 49.47 µM 4.48380279508357 9.81890657735094e-06 yes 71 3.66622154984913e-06 29 4798415 SGTC_2805 7950783 58.44 µM 4.37513464683645 1.55302568649144e-05 yes 72 6.06787725033692e-06 20 1178958 YDL195W SEC31 SGTC_1500 4488-1866 171 µM 4.29992412783921 2.1202525353446e-05 yes 73 8.54282969662111e-06 10 2900003 SGTC_294 k038-0071 157 µM 4.27886565271635 2.31134280260876e-05 yes 74 9.39240987529566e-06 49 24152826 SGTC_1803 st050068 52.4 µM 4.27128160841738 2.38407842210514e-05 yes 75 9.7176399196575e-06 158 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3209 9113616 49.47 µM 4.25598627521579 2.53742351313503e-05 yes 76 1.04064737301005e-05 18 16649353 SGTC_1899 st063254 59.6 µM 4.19366699149979 3.26429379929916e-05 yes 77 1.37240421915163e-05 10 3093813 SGTC_2584 androsterone 48.74 µM 4.00842562736593 6.76665319591826e-05 yes 78 3.05624410850793e-05 126 2754130 A steroid. SGTC_2319 6033012 152.6 µM 3.96791919436806 7.90480219236232e-05 yes 79 3.62514536027897e-05 32 847246 SGTC_3141 9094609 49.47 µM 3.9525652761309 8.38152701986902e-05 yes 80 3.86589139420324e-05 38 25236309 YDL196W YDL196W SGTC_1754 st042065 16.137 µM 3.93704845673541 8.89069532892568e-05 yes 81 4.1244977283574e-05 180 1126236 YIL048W NEO1 SGTC_3348 9149464 3.537 µM 3.74504201008904 0.000181319113306218 yes 82 9.01817963149339e-05 17 1951442 SGTC_2308 7584454 197.62 µM 3.66773703410639 0.000239433786300373 yes 83 0.000122353331449428 29 893577 SGTC_3290 9121031 71.43 µM 3.66259092787514 0.000243862123990651 yes 84 0.000124838541835864 17 17014854 SGTC_1256 0570-0116 285 µM 3.66188492434659 0.000244475579518198 yes 85 0.000125183162375037 26 410638 SGTC_1774 st048371 48.465 µM 3.5264795625185 0.000392727676962731 yes 86 0.00021056183307327 32 4242727 SGTC_525 k781-2675 26.7 µM 3.50151190485843 0.00042786724339606 yes 87 0.000231313151127848 67 3651118 YDL195W SEC31 SGTC_446 go6976 132 µM 3.46184253710115 0.00048974260989553 yes 88 0.000268245469541748 22 3501 A protein kinase C inhibitor. SGTC_3152 9099253 49.47 µM 3.39996299071481 0.000602989498903586 yes 89 0.000336974872096795 166 25236131 SGTC_1121 fusaric acid 630.51 nM 3.39234804172072 0.000618485866455816 yes 90 0.00034648178625482 57 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2817 7995342 71.43 µM 3.36740477724064 0.000671857387799503 yes 91 0.000379396128327933 41 18879975 SGTC_568 1193-0097 7.48 µM 3.35503591679962 0.000699870540691156 yes 92 0.000396773403652131 190 3646150 SGTC_794 k038-0031 316 µM 3.35043399812778 0.000710565084728781 yes 93 0.000403425175442964 131 6624242 SGTC_522 1273-0010 11.6 µM 3.31898880517861 0.000787769227515248 yes 94 0.000451720256003442 43 5705015 SGTC_2471 5466956 24.79 µM 3.30593008041069 0.000822043816527771 yes 95 0.000473308530007917 27 724419 SGTC_1764 st044502 93.5 µM 3.29300240666172 0.0008573212692983 yes 96 0.000495618130660634 45 8407 SGTC_2966 9084041 48.03 µM 3.27733807905614 0.000901930434082577 yes 97 0.00052395407439184 65 17741380 SGTC_1390 3413-2614 145 µM 3.24758177738385 0.000992596287526134 yes 98 0.000581951059479623 49 3421432 SGTC_675 1309-0189 238 µM 3.24021896725921 0.00101628567397121 no 99 0.000597189711760658 30 4246530 SGTC_158 k038-0087 26.446 µM 3.21069040196634 0.00111659672686186 no 100 0.000662082564667729 193 X158 SGTC_1974 st069448 26.9 µM 3.20894082274681 0.00112281579489132 no 101 0.000666124546453275 52 6323587 YNR016C ACC1 SGTC_846 0335-0850 148 µM 3.20432395966868 0.00113937961984531 no 102 0.000676900259726187 60 6819598 SGTC_2709 st078560 56 µM 3.19787221378174 0.0011629015152697 no 103 0.000692228073587086 31 17250903 SGTC_1836 st055642 81 µM 3.17934482315901 0.00123294291014002 no 104 0.000738041899669059 54 8571 SGTC_1255 0566-0045 221 µM 3.13949700655175 0.00139683980344641 no 105 0.00084619071826486 63 2788469 SGTC_3212 9128307 49.47 µM 3.06101366811706 0.00177913304394357 no 106 0.0011029451219553 91 27243542 SGTC_1696 st025591 34.7925 µM 3.03477854880992 0.00192675756209205 no 107 0.00120356180315569 68 2787147 SGTC_3172 9105863 49.47 µM 3.02950581690406 0.00195773752081061 no 108 0.00122477093307394 13 2348785 SGTC_708 3448-5400 146 µM 3.02683278297559 0.00197361514071978 no 109 0.00123565313554119 94 3462195 SGTC_986 1493-0483 84 µM 3.02371259905434 0.00199229665899863 no 110 0.00124846760007261 47 40079 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 3.02334460438957 0.00199451051053822 no 111 0.00124998692688502 56 5393153 SGTC_576 1073-0113 22.7 µM 3.02031293897636 0.00201283414542751 no 112 0.00126256817432515 139 5439563 SGTC_3346 9158254 43.5805 µM 3.00207584792249 0.00212632222572659 no 113 0.00134072678172856 67 17639500 SGTC_3311 9131146 2.8755 µM 2.98884307127191 0.00221226849687166 no 114 0.00140017960186476 175 4900406 YPR165W RHO1 SGTC_2540 epiandrosterone 100 µM 2.98420348591363 0.00224313996900303 no 115 0.00142158810533803 126 441302 A steroid. SGTC_3278 9139605 49.47 µM 2.96233085608559 0.00239400185952387 no 116 0.00152659754682764 57 7958859 SGTC_768 0384-0033 77.3 µM 2.9577419959114 0.00242679476747197 no 117 0.00154950694895493 149 3965305 YMR134W ERG29 SGTC_1263 0774-1208 64.8 µM 2.95674280709669 0.00243398882797117 no 118 0.00155453666858429 120 906585 SGTC_1664 st014217 9.02 µM 2.94245721944813 0.00253897487850916 no 119 0.00162809386407733 41 3982782 SGTC_1826 st055655 41.6 µM 2.94049717886214 0.00255369438559605 no 120 0.00163842992761555 92 676168 SGTC_1480 1070-0044 41.2 µM 2.92827128199676 0.00264726237788728 no 121 0.0017042625261432 64 3124987 SGTC_2466 5983409 37.09 µM 2.92413323511276 0.00267962651666441 no 122 0.00172708432619868 62 2879657 SGTC_875 0709-0210 25.7 µM 2.91409603062433 0.00275961804657112 no 123 0.00178360078125354 77 6251364 SGTC_3113 9123498 49.47 µM 2.90385988179417 0.00284340853787824 no 124 0.00184296540010777 47 8897275 SGTC_2725 haloperidol 53.21 µM 2.90033801215638 0.00287276396278373 no 125 0.00186380225791163 99 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2232 chlorophetanol 41.5365 µM 2.89507044658696 0.00291718031644819 no 126 0.0018953672515855 209 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_939 1165-0479 45.3 µM 2.88627564029118 0.0029927198441786 no 127 0.00194915288983231 107 1377347 SGTC_1800 st050079 29.0735 µM 2.85300127421157 0.0032947237910538 no 128 0.00216542239538406 244 3645560 SGTC_2629 bisabolol 100 µM 2.83857368768083 0.00343398458053176 no 129 0.00226578274674488 85 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1671 st016596 74.5 µM 2.82148799826307 0.00360572662470104 no 130 0.00239007130537011 66 2829167 SGTC_55 0767-0285 6.563 µM 2.81987272799113 0.00362235532128451 no 131 0.00240213500533002 102 3116166 SGTC_1437 4092-1038 11.6 µM 2.81928171756317 0.00362845676272259 no 132 0.00240656273681249 71 3977136 SGTC_3018 9082602 49.47 µM 2.80785135472218 0.00374828914194618 no 133 0.00249366207549876 89 17332089 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.79903948989217 0.00384307969998954 no 134 0.00256274343337 77 5024745 SGTC_1952 st077036 64.1 µM 2.79429447935875 0.00389500746955051 no 135 0.00260065452352781 97 2937007 SGTC_637 1181-0519 7.26 µM 2.78655786879048 0.00398102345840368 no 136 0.00266355528281885 187 6252091 YGR060W ERG25 SGTC_2705 st078069 42.8 µM 2.77856594816325 0.00407166046049345 no 137 0.00272997144360951 55 1530061 SGTC_50 0929-0078 56.389 µM 2.77439340682028 0.00411971171825829 no 138 0.00276523772117864 119 1377751 SGTC_221 trifluoperazine 10.304 µM 2.76995014754143 0.0041714378849391 no 139 0.00280324365279442 313 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2436 5633522 8.09 µM 2.76056733582413 0.0042825809001344 no 140 0.00288505309337094 78 5724242 SGTC_1264 0783-0040 158 µM 2.76030565068274 0.00428571825676848 no 141 0.00288736529163082 90 2855798 SGTC_813 k007-0158 173 µM 2.74614005098487 0.0044586468806158 no 142 0.00301505079017277 122 6523916 SGTC_2757 clomiphene 4.22 µM 2.72656654273712 0.00470784426599634 no 143 0.0031998523603179 128 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_575 k072-0246 11.9 µM 2.71854849897131 0.00481346146184479 no 144 0.00327845212203726 91 6796779 SGTC_967 1306-0166 352 µM 2.71696474989511 0.004834571409499 no 145 0.00329418121020596 113 4437607 SGTC_3126 9127922 49.47 µM 2.70835530980298 0.00495077763669012 no 146 0.00338087943871194 116 45595682 SGTC_2323 6148992 148.28 µM 2.70525766710159 0.00499319300602966 no 147 0.00341257130283386 92 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2312 7706453 155.7 µM 2.6997874219434 0.00506888698669807 no 148 0.00346918970095322 94 976098 SGTC_2409 alverine citrate 63.97 µM 2.69844410645344 0.00508763053211879 no 149 0.00348322176595989 130 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1934 st074720 32.6 µM 2.66712722392059 0.00554244901834188 no 150 0.00382513528540935 141 17250992 SGTC_611 3453-1652 23.7 µM 2.6576127322603 0.00568760721272673 no 151 0.00393481328909155 102 1560575 SGTC_2634 4'-methoxyflavone 100 µM 2.65379658685487 0.00574677025337869 no 152 0.00397958952974321 108 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_940 3232-1287 54.8 µM 2.63610385133931 0.00602826232437802 no 153 0.00419320301704749 121 1585493 YIL048W NEO1 SGTC_417 st075190 100 µM 2.61245564150665 0.00642356216663288 no 154 0.00449471785681612 82 222757 SGTC_2153 5569715 200 µM 2.60901119106448 0.00648301306631995 no 155 0.00454021363360424 64 2054701 SGTC_1281 0884-0031 11.8 µM 2.60577255756425 0.00653935502857537 no 156 0.00458336545245384 113 1548255 SGTC_1738 st035555 74 µM 2.59651212740575 0.00670285368658304 no 157 0.00470877905633412 132 5331140 SGTC_3005 9076496 71.4286 µM 2.585474989829 0.00690243204321294 no 158 0.00486224637918194 59 21368410 SGTC_1581 himbacine 57.9 µM 2.58327381369364 0.00694285650915731 no 159 0.00489338080643388 128 5281825 An alkaloid muscarinic receptor antagonist. SGTC_482 fipronil 114 µM 2.58263571829781 0.00695461410516625 no 160 0.00490243947087791 39 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1513 0337-0559 19 µM 2.57168934091309 0.00715906817776191 no 161 0.00506018294463675 112 775073 SGTC_1646 st011709 75.6 µM 2.57078149918563 0.0071762603834633 no 162 0.00507346622224261 73 5757843 SGTC_1510 1123-0200 71.5 µM 2.55119128241105 0.00755622612207466 no 163 0.00536776934899594 160 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2426 5582046 32.21 µM 2.54395058129928 0.00770108582092725 no 164 0.00548032952233271 114 2251934 SGTC_1023 4482-3888 16 µM 2.54325231130063 0.00771518402395813 no 165 0.00549129457587222 104 3303168 SGTC_479 n-linoleoylglycine 10 µM 2.53400714403691 0.00790399838095275 no 166 0.00563832163506272 74 6433346 An anti-infammatory. SGTC_2560 caryophyllene 100 µM 2.52037387816892 0.00818984526510669 no 167 0.00586151206386643 114 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_127 0180-0333 59.125 µM 2.51233729642493 0.00836256854279808 no 168 0.005996719776828 182 771601 SGTC_717 1532-0246 73.2 µM 2.51187070664996 0.00837269406736493 no 169 0.00600465394646692 131 9561992 SGTC_3130 9127414 49.47 µM 2.4956816968205 0.00873074447454178 no 170 0.00628576765769017 85 1494646 SGTC_1699 st031318 29.054 µM 2.49240343691225 0.0088048623087232 no 171 0.00634409130856828 104 5340658 SGTC_2703 st077852 53.4 µM 2.47977379985729 0.00909558430142719 no 172 0.0065732876601213 114 6281836 SGTC_782 0083-0095 30.5 µM 2.47577402645364 0.00918939125320359 no 173 0.00664738473822278 141 3591729 An indicator and reagent. SGTC_725 1497-0963 19 µM 2.46364188907138 0.00947912637195692 no 174 0.00687667236670974 102 3549977 SGTC_778 3456-2434 196 µM 2.4635171488108 0.00948214639433503 no 175 0.00687906569050026 196 5539063 SGTC_917 harmaline 728.087 nM 2.45929334855701 0.00958490443967436 no 176 0.00696054082404379 129 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2697 mebhydrolin 72.4 µM 2.45089885084541 0.00979202169743494 no 177 0.0071249995338799 196 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3078 9116413 49.47 µM 2.41942763923505 0.0106037053244312 no 178 0.00777247660099038 137 17177322 SGTC_814 3342-0569 96 µM 2.41208445092184 0.0108013205555469 no 179 0.00793080353528296 143 4346283 SGTC_3245 9134821 49.47 µM 2.404964557634 0.0109959800811095 no 180 0.00808701716320056 140 17014901 SGTC_459 nigericin 15.3 µM 2.40491371527082 0.0109973810265025 no 181 0.00808814232322569 179 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3120 9124077 49.47 µM 2.38822411426959 0.0114657316174471 no 182 0.00846500706462661 94 18774327 YGL155W CDC43 SGTC_2293 7624732 200 µM 2.38643005773574 0.011517093907267 no 183 0.00850642157634865 132 894453 SGTC_2020 4017018 200 µM 2.38622271006392 0.0115230429549131 no 184 0.0085112194922113 128 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3165 9101544 49.47 µM 2.38580270945583 0.0115351014429181 no 185 0.00852094536210605 117 5002184 SGTC_472 calcifediol 10 µM 2.38387671133761 0.0115905385458128 no 186 0.00856567031537174 81 5283731 A vitamin D metabolite. SGTC_1884 5633444 25 µM 2.37547769435291 0.0118350048533468 no 187 0.00876312583260918 175 5724239 SGTC_3191 9110352 49.47 µM 2.36762100522857 0.0120677231204691 no 188 0.00895143229724285 111 17122424 SGTC_2924 9010168 62.78 µM 2.36061765485794 0.0122784993020092 no 189 0.00912226499119543 144 2993929 SGTC_1715 st032160 10.2275 µM 2.34912692977694 0.0126312416137944 no 190 0.00940874541096759 158 5289825 SGTC_623 k072-0108 16.9 µM 2.34783735438606 0.0126713711373512 no 191 0.0094413823870951 146 5382803 SGTC_625 k213-0058 121 µM 2.34500810993216 0.0127597994331539 no 192 0.00951333286878784 312 3655420 SGTC_3121 9125696 49.47 µM 2.34476439348356 0.012767441729559 no 193 0.00951955318762135 63 1235365 SGTC_3146 9095609 49.47 µM 2.33313928150704 0.0131366029126279 no 194 0.0098204181862381 129 17173999 SGTC_2005 4024620 188 µM 2.33266008089682 0.0131520161135407 no 195 0.00983299645178922 134 236743 SGTC_345 1362-0200 395 µM 2.33165713315089 0.0131843259165384 no 196 0.00985936780874906 137 1419823 SGTC_2191 5911152 200 µM 2.30507492709285 0.0140660184595191 no 197 0.0105811887207841 135 2875902 SGTC_1197 1601-0112 267 µM 2.30120897817986 0.0141983877076083 no 198 0.0106899108295074 170 7350313 SGTC_984 1492-0255 2.91 µM 2.29606644277264 0.0143761292158538 no 199 0.0108360413256582 137 1585198 SGTC_429 1112-0049 25.5 µM 2.28647258834249 0.0147128465791161 no 200 0.011113312994062 178 2836170 SGTC_689 0833-0039 98 µM 2.28171389336704 0.0148823657544761 no 201 0.0112531186413085 150 5374726 SGTC_2241 6772625 37.8075 µM 2.27567428944033 0.0150999308937262 no 202 0.0114327556455038 148 2285411 SGTC_2268 7933382 153.85 µM 2.27549589317057 0.0151063986171246 no 203 0.0114380993814779 199 935025 YOR257W CDC31 SGTC_1979 st071809 45.3 µM 2.27491595421906 0.0151274406457988 no 204 0.0114554860436372 130 4976333 SGTC_332 4112-0506 40.9 µM 2.25553480098152 0.015845279916032 no 205 0.012049890213247 143 2790355 SGTC_6 0844-0013 19.835 µM 2.25365087395064 0.0159165896413671 no 206 0.0121090700780629 372 1584900 SGTC_2326 6164455 177.58 µM 2.24346500825859 0.0163069248816233 no 207 0.0124334219384274 149 2888790 SGTC_1375 2910-0797 186 µM 2.24080778968975 0.0164100911290728 no 208 0.0125192640794202 165 742508 SGTC_919 tnp00227 403.569 nM 2.23590031532324 0.0166020928581422 no 209 0.0126791508309295 190 1269246 A methoxyflavone. YNL221C POP1 SGTC_2902 5787006 60.46 µM 2.22212833900355 0.0171512109235291 no 210 0.0131373168008638 157 591003 SGTC_2110 5483698 200 µM 2.21718142743123 0.0173522080636427 no 211 0.0133053481067548 147 2848765 YHR062C RPP1 SGTC_447 ml7 120 µM 2.2156542472677 0.0174146636525201 no 212 0.0133575952970787 168 4216 Selective myosin light chain kinase inhibitor. SGTC_2038 4100038 30.985 µM 2.20843448004803 0.0177125285797064 no 213 0.0136070002217447 186 3596803 SGTC_1293 1000-1278 195 µM 2.20810965598926 0.0177260313748125 no 214 0.0136183150307453 176 678847 SGTC_3166 9102297 49.47 µM 2.20191859779619 0.017985074886099 no 215 0.0138355295184382 194 25237072 SGTC_2600 tangeritin 87.95 µM 2.19962096300341 0.0180820293536205 no 216 0.0139168993041236 163 68077 A bioactive flavone. SGTC_937 3122-0005 46.7 µM 2.19718490679357 0.0181853111301134 no 217 0.0140036215456903 188 759535 SGTC_464 bw-b 70c 158 µM 2.18639447623826 0.0186488607193581 no 218 0.0143933786968102 209 5353454 SGTC_1049 3226-0134 66 µM 2.18369573442569 0.0187663568293683 no 219 0.0144923067157312 196 5702385 SGTC_2904 7225135 42.03 µM 2.17942248716946 0.018953691033631 no 220 0.0146501485604346 126 4446116 SGTC_1324 1418-0026 34.4 µM 2.17765777420946 0.0190315167891002 no 221 0.0147157624057039 170 1372513 SGTC_2285 7945142 200 µM 2.17171148617611 0.0192957581010858 no 222 0.014938715806475 180 2970608 SGTC_3023 9089636 49.47 µM 2.16518034273531 0.0195895757799118 no 223 0.0151869385537352 131 17249241 SGTC_391 gliotoxin 8.33 µM 2.15192847609517 0.02019742763165 no 224 0.015701494029098 224 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2437 5741531 144.16 µM 2.14839075931216 0.0203623786855257 no 225 0.0158413631293309 189 2262990 SGTC_2910 7948405 25.97 µM 2.14815011616372 0.0203736403699635 no 226 0.0158509160187238 155 2971328 SGTC_3118 9124250 49.47 µM 2.14242628987554 0.0206430657288623 no 227 0.0160795971147971 147 1504786 SGTC_2031 5180455 200 µM 2.14231960755284 0.020648115867058 no 228 0.0160838860393498 145 29949 SGTC_2771 fluoxetine 41.05 µM 2.14012799579527 0.0207520943874486 no 229 0.0161722120834496 169 3386 A selective serotonin reuptake inhibitor. SGTC_955 1216-0110 33 µM 2.13858856976038 0.0208253955083568 no 230 0.0162345020156156 262 3619719 SGTC_1937 st074714 47.2 µM 2.13829343840877 0.0208394734585074 no 231 0.0162464673902618 194 17250970 SGTC_736 0958-0254 92.6 µM 2.1320033528909 0.0211414356088533 no 232 0.0165032854623339 215 6812352 SGTC_3229 9132204 49.47 µM 2.12881965231222 0.0212956780941816 no 233 0.0166345921716655 103 17682924 SGTC_2686 alizarin 95.37 µM 2.12563179893048 0.0214510741975306 no 234 0.016766964863042 181 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1600 coumarin 106 71.1 µM 2.11083553549686 0.0221849439979391 no 235 0.0173932252866502 202 100336 A hepatotoxic, DNA x-linker. SGTC_1078 idebenone 36.1 µM 2.10998439647948 0.0222277957791666 no 236 0.0174298499520582 268 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.10851012927526 0.0223021850716015 no 237 0.0174934437599733 167 2724278 An inhibitor of dopamine biosynthesis. SGTC_987 1497-1013 404 µM 2.10752118208532 0.0223522034594645 no 238 0.0175362137862924 148 1676435 SGTC_3198 9112019 49.47 µM 2.10605522934968 0.0224265216275695 no 239 0.0175997775874669 166 45595555 SGTC_2895 9054447 58.44 µM 2.10440301353938 0.0225105323082922 no 240 0.0176716533861804 137 2697450 SGTC_1165 k072-0275 30.3 µM 2.09979922193657 0.0227460236342663 no 241 0.0178732533659548 205 6153523 YGL055W OLE1 SGTC_2506 ethyl hematommate 54.16 µM 2.09839217163178 0.0228184094386332 no 242 0.0179352581277565 162 3940691 An allergen. SGTC_438 sphingosine 6.67 µM 2.09718462780339 0.0228806862942744 no 243 0.0179886173737039 163 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2006 4011487 200 µM 2.08218457411934 0.0236662969578719 no 244 0.0186628068700599 286 45595294 SGTC_1828 st055811 49 µM 2.07779336959802 0.0239005290247226 no 245 0.018864197393283 136 5877589 SGTC_2366 9070441 60.58 µM 2.07510927522729 0.0240446590174944 no 246 0.0189882041522191 220 6837235 SGTC_1230 0170-0365 3.77 µM 2.06830767097842 0.0244131633794728 no 247 0.0193055504487918 329 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3 0833-0587 95.581 µM 2.06790335306444 0.0244352174218745 no 248 0.0193245560316184 171 5382644 SGTC_3227 9130768 49.47 µM 2.06547218715866 0.0245681814117346 no 249 0.0194391722505505 127 17720899 SGTC_1274 0865-0114 173 µM 2.06136071558933 0.0247944253082258 no 250 0.0196343198758357 210 870624 SGTC_2242 6630449 61.2675 µM 2.06074223229369 0.024828609625802 no 251 0.0196638191339118 206 691249 YDR170C SEC7 SGTC_2416 tofa 880 nM 2.04942985371021 0.0254608647777454 no 252 0.0202100502560775 246 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1868 st057644 42.7 µM 2.0481666291183 0.0255322967740838 no 253 0.020271837534536 240 688665 SGTC_2680 butyl paraben 22.24 µM 2.04337151169993 0.0258049772385018 no 254 0.0205078376863488 146 7184 An antifungal and steroid mimetic. SGTC_2265 7929201 200 µM 2.03967119664703 0.0260170626174387 no 255 0.0206915427944772 219 1265108 SGTC_2585 alliin 100 µM 2.0355759182408 0.0262534833105015 no 256 0.0208964790063827 234 87310 A garlic compound which reacts with lipids. SGTC_2003 4023581 200 µM 2.01206874039555 0.0276455517591759 no 257 0.0221063456581489 231 16641307 SGTC_1051 3253-3903 78 µM 2.00906312876464 0.0278278979980675 no 258 0.0222652196346477 243 5509239 SGTC_2498 4'-Methoxychalcone 54.63 µM 2.00277235401492 0.0282127950388589 no 259 0.0226008642721346 212 641818 YHR062C RPP1 SGTC_2871 9038510 12.99 µM 1.99773507027288 0.0285241839122686 no 260 0.0228726949756255 210 4945164 SGTC_649 1123-0311 367 µM 1.99295915179933 0.0288220511854956 no 261 0.0231329601046426 295 693629 YIL048W NEO1 SGTC_1251 0490-5699 265 µM 1.99230738656624 0.0288629006759415 no 262 0.0231686708727795 260 3883818 SGTC_3098 9119039 49.47 µM 1.98981558431648 0.0290195187544699 no 263 0.0233056270276312 225 17161528 SGTC_466 geldanamycin 89.2 µM 1.98698267650976 0.0291984336422329 no 264 0.0234621583073235 135 5288382 HSP90 inhibitor. SGTC_2657 nystatin 74.44 µM 1.98670684463827 0.0292159029029621 no 265 0.0234774464408914 219 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_747 3448-8087 38.7 µM 1.97821080593799 0.0297582492296595 no 266 0.0239524650978551 252 5168703 SGTC_2925 9010536 32.5 µM 1.97501288341074 0.0299645412978995 no 267 0.0241333429911587 304 2994177 SGTC_456 gingerol 170 µM 1.97037479183736 0.0302658422063869 no 268 0.0243977162150979 221 442793 A herb. SGTC_3324 9138759 60.749 µM 1.96558725757474 0.0305794804821871 no 269 0.0246731536052693 216 45595710 SGTC_553 k007-0256 45.7 µM 1.96558510830919 0.0305796218858816 no 270 0.0246732778407 249 6287000 SGTC_1081 sertraline 6 µM 1.95713849723176 0.0311395364572128 no 271 0.0251655936764887 275 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2759 disulfiram 3.38 µM 1.95565959931724 0.0312384377937073 no 272 0.0252526334815479 249 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_355 1311-2252 105 µM 1.95541287424633 0.0312549627992343 no 273 0.0252671788864686 257 5338538 SGTC_311 1315-0136 58 µM 1.93860978002653 0.0323975206387897 no 274 0.0262744358855399 201 6759207 SGTC_1686 st019653 115.5 µM 1.92471696258871 0.0333680185659749 no 275 0.0271323886084534 202 97252 SGTC_2553 4-methylesculetin 85.09 µM 1.92320081073319 0.0334753649537765 no 276 0.0272274177460871 252 5319502 SGTC_416 estradiol valerate 100 µM 1.91911048573665 0.033766386432947 no 277 0.0274851763588143 239 13791 A steroid. SGTC_486 niguldipine 82 µM 1.91461018896829 0.0340889786557656 no 278 0.0277711173798006 205 1236 A calcium channel blocker. SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.91383540111945 0.0341447722093002 no 279 0.02782059529079 270 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2865 9030313 51.95 µM 1.91319676053708 0.0341908180350753 no 280 0.0278614340431541 196 42562754 SGTC_3167 9103034 49.47 µM 1.91293092589418 0.0342099996864895 no 281 0.0278784479202832 157 5127859 SGTC_1137 ixabepilone 100 µM 1.90836957865994 0.0345405101175138 no 282 0.0281717329331378 295 154225 A novel microtubule stabilizer. SGTC_413 propylparaben 100 µM 1.89968214797518 0.0351772472399009 no 283 0.0287374222342069 225 7175 A pharmaceutical preservative. SGTC_1707 st032323 6.317 µM 1.88000807774638 0.0366548774225718 no 284 0.0300534885189348 318 3132057 YMR211W DML1 SGTC_326 k292-0812 17.5 µM 1.87943379255595 0.0366987606042554 no 285 0.0300926428962485 197 3579357 SGTC_2440 5628896 157.78 µM 1.87854948813502 0.0367664174827694 no 286 0.0301530168708454 229 5522048 SGTC_577 r071-0003 38.6 µM 1.87829387171944 0.0367859933261193 no 287 0.0301704872253129 366 4568517 YMR134W ERG29 SGTC_47 0149-0135 24.25 µM 1.87381217684868 0.0371306014374299 no 288 0.0304781587309547 248 5239155 SGTC_1368 1852-0141 284 µM 1.87270879496943 0.0372158465719212 no 289 0.030554304106411 264 2838987 SGTC_786 4544-0069 423 µM 1.86417961652997 0.0378802031921135 no 290 0.0311482424196026 299 748821 YLR208W SEC13 SGTC_1477 0139-0234 16 µM 1.86207244454644 0.0380458177461137 no 291 0.0312964397436694 238 620880 SGTC_1145 3546-0597 10.2 µM 1.8593834663799 0.0382580170436176 no 292 0.0314864018255496 286 875334 SGTC_2305 7443522 69.23 µM 1.85355829417291 0.0387210177947232 no 293 0.0319011894755561 264 5415886 SGTC_2105 5350118 200 µM 1.8490802502751 0.0390800399104781 no 294 0.0322231128569374 268 2133313 SGTC_2330 7979373 200 µM 1.84666039572361 0.039275174093136 no 295 0.0323981874983384 315 1863007 SGTC_788 1182-0090 188 µM 1.84295386398577 0.0395756010900883 no 296 0.0326678734246837 386 5715185 SGTC_3298 9116858 71.43 µM 1.83743808987078 0.0400261308830681 no 297 0.0330726240600278 251 2506942 SGTC_3204 9114183 49.47 µM 1.836120650725 0.0401343539601245 no 298 0.0331699073756646 275 17027248 SGTC_2694 st077685 81.9 µM 1.83261252256284 0.0404236942707593 no 299 0.0334301072750692 291 2838096 SGTC_1679 SEC14.276 6.7 µM 1.82534412359078 0.0410285609512321 no 300 0.0339745578126807 328 1005053 YMR079W SEC14 SGTC_2922 7999257 32.47 µM 1.82158899409261 0.0413439218476862 no 301 0.0342586860675024 229 2988377 SGTC_253 dyclonine 31.25 µM 1.82075562632137 0.0414141749281066 no 302 0.0343220061342363 320 3180 An oral anasthetic. SGTC_605 1315-0399 119 µM 1.8099002626697 0.0423381516266143 no 303 0.0351556277044488 315 24020461 SGTC_2897 9048598 12.99 µM 1.80745921363272 0.0425482065188514 no 304 0.0353453542861754 243 6467404 SGTC_136 0097-0015 404.482 µM 1.80470441706681 0.0427862710533098 no 305 0.0355604741324258 308 4861337 SGTC_706 4262-0057 46.9 µM 1.80448925532898 0.0428049101802943 no 306 0.0355773210316038 299 883298 SGTC_2259 7964009 200 µM 1.79874148351125 0.0433052647278186 no 307 0.0360297917893576 261 313134 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.79565896995234 0.0435755427787281 no 308 0.0362743855356555 316 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2754 granisetron 64.02 µM 1.79505272010685 0.0436288592796162 no 309 0.0363226503292167 312 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1204 4049-0315 18.3 µM 1.79498674795954 0.0436346643593513 no 310 0.0363279056770174 302 588402 SGTC_292 k038-0015 474 µM 1.79425795804566 0.0436988341723429 no 311 0.0363860025782575 275 46368540 SGTC_3082 9117008 49.47 µM 1.78351697659311 0.0446534353580385 no 312 0.0372510934921458 275 41448529 SGTC_1552 6-methylflavone 10.6 µM 1.78174325676739 0.0448126779953941 no 313 0.0373955546839395 228 689013 SGTC_1785 bathophenanthroline 24 µM 1.77954451804582 0.0450107127479005 no 314 0.0375752665355351 343 72812 An iron chelator. SGTC_2571 chrysanthemic acid 100 µM 1.77857202586602 0.0450985270027077 no 315 0.0376549768838919 266 2743 An insecticide. SGTC_389 tpck 16.7 µM 1.76696560249065 0.0461572428939224 no 316 0.0386169945575312 281 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3081 9117243 49.47 µM 1.76608237012087 0.0462386202153859 no 317 0.0386910153745007 270 45595589 SGTC_2849 9019321 12.99 µM 1.76566644705877 0.0462769815005635 no 318 0.038725912538491 297 16489627 SGTC_2196 6573537 42.6665 µM 1.76504152952936 0.0463346667358991 no 319 0.0387783931521272 249 2903087 SGTC_1326 1431-2094 10.8 µM 1.76222794442183 0.0465951001771904 no 320 0.0390153962490616 335 616278 SGTC_2942 9052777 62.25 µM 1.76000207203315 0.0468019644210462 no 321 0.0392037276283716 344 6469503 SGTC_1282 0886-0010 32.4 µM 1.75871956673638 0.0469214897864851 no 322 0.0393125761353301 322 2836211 YNL267W PIK1 SGTC_1897 st060201 15 µM 1.75702912105144 0.0470794077414538 no 323 0.0394564228287239 265 611878 SGTC_2228 7354201 200 µM 1.75378412287024 0.0473837427271107 no 324 0.039733752305019 233 753451 SGTC_2099 5377090 177.372 µM 1.74884023015573 0.0478504383010706 no 325 0.0401593202853115 321 2243829 SGTC_1134 3477-0009 42.5 µM 1.74836321687691 0.0478956615835808 no 326 0.0402005765025043 357 3973534 SGTC_1431 4049-0260 9.09 µM 1.74802039729662 0.0479281837476417 no 327 0.04023024775013 294 3854841 SGTC_804 1595-0054 20.9 µM 1.74577233438098 0.0481418883302242 no 328 0.0404252600514637 301 761523 Stimulates phospholipase C. SGTC_2956 9076196 2.52 µM 1.74122011281684 0.0485769649702438 no 329 0.0408225015227591 316 16423868 SGTC_3077 9117319 49.47 µM 1.74082513274589 0.0486148627655074 no 330 0.0408571175539445 242 17154678 SGTC_439 amiodarone 34.4 µM 1.7389480135348 0.0487952929850795 no 331 0.041021953822062 389 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2531 methyl deoxycholate 70.07 µM 1.73437647193212 0.0492369524558664 no 332 0.0414256534505718 288 16667744 Haematoxylin. SGTC_1151 3909-8316 15.3 µM 1.73415558438741 0.0492583731229212 no 333 0.0414452406422573 314 800431 SGTC_2601 securinine 100 µM 1.73148412324318 0.0495180289033285 no 334 0.0416827270962826 305 442872 A GABA receptor antagonist. SGTC_581 0958-0271 211 µM 1.73042831928878 0.0496209497058705 no 335 0.0417768889017592 400 4591145 SGTC_3241 9133421 49.47 µM 1.72487596452824 0.0501650109619211 no 336 0.0422749139893841 188 17018221 SGTC_1308 1187-1617 41.4 µM 1.72211012553034 0.0504377974342142 no 337 0.0425247856078183 371 2882570 SGTC_977 1348-1378 135 µM 1.72118345360576 0.0505294562093243 no 338 0.042608769691009 300 X977 SGTC_91 0417-1751 58.384 µM 1.72054537763123 0.0505926465499901 no 339 0.042666676309682 410 6795624 SGTC_3057 9095946 49.47 µM 1.7076966112758 0.0518785393681281 no 340 0.0438463256329094 273 24540043 SGTC_650 1328-0195 38 µM 1.70599481072956 0.0520507848095992 no 341 0.0440045228828084 337 2780821 SGTC_3264 9137442 49.47 µM 1.70295781272013 0.052359298995296 no 342 0.0442879818170695 268 17015726 SGTC_1778 st046819 58.9 µM 1.7022618111147 0.052430206580953 no 343 0.0443531501321824 371 671715 SGTC_2449 5812982 45.77 µM 1.7001375592204 0.0526470936162283 no 344 0.0445525269534026 264 776185 SGTC_175 3793-3120 23.7 µM 1.69750170655112 0.0529172044608341 no 345 0.0448009243681813 310 5322297 SGTC_2823 7987624 58.44 µM 1.69469076004784 0.053206468102617 no 346 0.0450670497100637 382 2239440 SGTC_654 1124-0271 80.9 µM 1.6839141358114 0.0543270798351509 no 347 0.0460991320209464 357 5403748 SGTC_2648 atorvastatin 78.68 µM 1.6751403238379 0.0552531489905177 no 348 0.0469533514476065 287 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_724 3910-0327 137 µM 1.67349825342592 0.0554278453921109 no 349 0.0471146250473861 346 2885483 SGTC_2675 theaflavin digallate 100 µM 1.67268955068139 0.0555140417001592 no 350 0.0471942136840459 346 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_669 0108-0021 26.2 µM 1.67221348220653 0.0555648333478259 no 351 0.0472411164263468 482 17201 SGTC_876 0720-0963 56.8 µM 1.66883581829496 0.0559262497437344 no 352 0.047574961025781 346 765861 SGTC_931 2812-0076 566 µM 1.66697369090071 0.0561262924271979 no 353 0.0477598181938702 348 3450959 SGTC_3192 9110362 49.47 µM 1.66181825829566 0.0566830691518744 no 354 0.0482746101032216 329 16649480 SGTC_2036 5160441 105 µM 1.66153363537001 0.0567139341638834 no 355 0.0483031597119983 426 134534 YIL048W NEO1 SGTC_1435 4092-0789 56.7 µM 1.66076075163961 0.0567978138270888 no 356 0.0483807533264003 324 2248285 SGTC_49 0717-0965 32.132 µM 1.65918253232453 0.056969398544864 no 357 0.0485395081778444 351 5889349 YGL099W LSG1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.65840875598534 0.0570536728322092 no 358 0.0486174952351024 456 6708739 YPR165W RHO1 SGTC_2979 9012552 45.46 µM 1.65800114246101 0.0570981066872238 no 359 0.0486586178879276 260 17100905 SGTC_1911 st060208 74.3 µM 1.65754243443823 0.0571481429138123 no 360 0.048704928527104 372 688783 SGTC_1949 st076024 69.1 µM 1.65585038760898 0.0573330112100379 no 361 0.0488760603908613 366 2921930 SGTC_3303 9125618 40.5795 µM 1.64306638942008 0.0587450032728377 no 362 0.0501845989930605 433 22695467 SGTC_2017 5132927 60.65 µM 1.64106181359469 0.0589688631554443 no 363 0.0503922922475225 370 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_431 k089-0097 107 µM 1.63794455490986 0.0593183102376047 no 364 0.0507166302120632 429 5499420 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.63736737466274 0.0593831903712311 no 365 0.0507768654521799 297 364106 SGTC_858 0438-0351 2.77 µM 1.62461006074309 0.0608314758439077 no 366 0.0521228360320852 371 2799119 SGTC_924 2046-0044 21.3 µM 1.62272625880351 0.0610476569258059 no 367 0.052323967725415 355 3623589 SGTC_1273 0849-0096 14.1 µM 1.61573457825586 0.0618552611958458 no 368 0.0530758557611322 364 5286025 SGTC_1032 k061-1018 98.7 µM 1.61428288480907 0.0620239861435591 no 369 0.0532330403837711 427 4005393 SGTC_1674 st016616 23.6 µM 1.61166466209946 0.0623292001471289 no 370 0.0535174657081257 380 625830 SGTC_1616 st002734 56.1 µM 1.6091126786163 0.0626278184422485 no 371 0.0537958527094387 399 4026101 SGTC_1825 st052143 62.6 µM 1.60620146966089 0.0629698315750077 no 372 0.0541148252804592 299 674173 SGTC_2556 citropten 84.59 µM 1.60140830676309 0.0635361070640686 no 373 0.0546432570512583 421 2775 A potential DNA crosslinker. SGTC_1573 oleylamine 1.06 µM 1.59834944034661 0.0638995550944935 no 374 0.0549826150331479 390 5356789 An amine of the fatty acid oleic acid. SGTC_2344 7990960 76.95 µM 1.59368064996267 0.0644574056065027 no 375 0.0555037901794442 350 140813 SGTC_852 0418-0143 439 µM 1.59309840367807 0.064527239865609 no 376 0.0555690587051052 455 5369229 SGTC_3037 9091026 49.47 µM 1.59248702134324 0.0646006319306125 no 377 0.0556376585102505 526 25236398 YIL048W NEO1 SGTC_3104 9120930 49.47 µM 1.58950560405033 0.0649594590921589 no 378 0.055973144926833 313 17014836 SGTC_687 k029-0044 34.9 µM 1.58832676453482 0.0651017638728442 no 379 0.0561062341836253 384 5829338 SGTC_831 k061-1017 217 µM 1.58784121205223 0.0651604481205964 no 380 0.0561611248590083 543 1240153 SGTC_3274 9138298 49.47 µM 1.58773770043751 0.0651729639207975 no 381 0.0561728321008916 408 17015756 SGTC_3147 9097027 49.47 µM 1.57876461092511 0.0662650247939773 no 382 0.0571950293278091 370 25236841 SGTC_1637 st007924 17.4 µM 1.57831179760538 0.0663205073500192 no 383 0.0572469984631482 364 683336 SGTC_1036 k216-0215 33.5 µM 1.57766929337538 0.066399294183648 no 384 0.0573208020853702 453 622330 SGTC_891 0929-0073 133 µM 1.57120404454325 0.067196131581391 no 385 0.0580676304628527 357 5603632 SGTC_2100 5377183 190 µM 1.5654402703941 0.067912728608918 no 386 0.0587398561080965 406 2844202 SGTC_830 4076-0286 57.8 µM 1.56224679623687 0.0683122988241148 no 387 0.0591149301544404 573 6866659 SGTC_501 nsc-95397 161 µM 1.56222434532352 0.0683151143094651 no 388 0.0591175736517379 345 262093 SGTC_2048 5246248 200 µM 1.56188583216138 0.0683575768378525 no 389 0.0591574433422475 326 677046 SGTC_3182 9108849 49.47 µM 1.55807250584837 0.0688373221072088 no 390 0.0596080306980349 438 17133045 SGTC_493 zm226600 134 µM 1.55432163905504 0.0693117377654737 no 391 0.0600538572026466 405 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2133 5320837 200 µM 1.54667966950967 0.0702860949104039 no 392 0.0609702539366751 388 2841355 SGTC_2194 5927483 104.545 µM 1.54626218702191 0.0703396261600839 no 393 0.0610206300896999 428 760979 SGTC_104 0074-0074 590.992 µM 1.5451610581643 0.0704809676296041 no 394 0.0611536555437347 252 3943124 SGTC_2106 5357045 167.29 µM 1.54447936317123 0.0705685797139406 no 395 0.0612361234403407 415 668842 SGTC_2287 7945887 168.79 µM 1.54192442672342 0.0708976874914891 no 396 0.0615459796738166 397 1245853 SGTC_286 k060-0067 22.9 µM 1.54182469067085 0.0709105586137503 no 397 0.0615581001965814 389 5985051 SGTC_728 3030-5151 22.5 µM 1.54106855006884 0.0710081983556476 no 398 0.0616500515801804 361 3125388 SGTC_1840 st055363 71 µM 1.53214601320217 0.0721681689452318 no 399 0.0627432036401922 354 676033 SGTC_1831 st055328 12 µM 1.53208482369405 0.0721761737055543 no 400 0.0627507521364943 409 1103068 SGTC_594 1487-1584 10.8 µM 1.52643343610264 0.0729184213946158 no 401 0.0634509779616528 410 5013332 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.52315954998709 0.0733510753093827 no 402 0.0638593966555592 372 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1602 st001878 87.6 µM 1.52242447414889 0.0734484871882022 no 403 0.0639513781505666 387 595405 YLR310C CDC25 SGTC_500 h-89 112 µM 1.52050743660269 0.0737029974774775 no 404 0.0641917455707756 442 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1195 1502-0147 41.1 µM 1.51793852745908 0.0740451080419271 no 405 0.0645149481225448 434 817940 SGTC_2001 4023502 57.655 µM 1.51458563370104 0.0744934479533147 no 406 0.0649386863121236 439 108941 YCR052W RSC6 SGTC_1660 st012960 28.1 µM 1.50899428425184 0.0752457134253513 no 407 0.0656501217286013 436 24207266 SGTC_497 capsazepine 133 µM 1.50543829158162 0.075727144329291 no 408 0.0661057153371984 390 2733484 A calcium channel blocker. SGTC_185 k048-0037 25.491 µM 1.50163159212564 0.0762451138783141 no 409 0.0665961398532967 419 6827589 SGTC_549 1661-1316 519 µM 1.50080086323122 0.0763585069812617 no 410 0.0667035376775131 425 2857282 SGTC_197 4544-0043 41.561 µM 1.49659981768217 0.0769339087533639 no 411 0.0672487088053644 481 896523 SGTC_516 3992-2719 87.3 µM 1.49529901295195 0.0771127418206809 no 412 0.0674182112929375 382 5350887 YDR037W KRS1 SGTC_559 1550-0661 158 µM 1.49321761231325 0.0773995471321512 no 413 0.0676901166535849 413 5830875 SGTC_1 0258-0098 57.368 µM 1.49105657894075 0.0776981819192698 no 414 0.0679733205014574 352 6790032 YDR047W HEM12 SGTC_508 roscovitine 141 µM 1.48667474839431 0.0783063940556828 no 415 0.0685503675522436 389 160355 A CDKinase inhibitor. SGTC_1025 k007-0731 70 µM 1.48617774431373 0.0783756071631996 no 416 0.0686160563380331 412 6256118 SGTC_3051 9093778 49.47 µM 1.48576917087628 0.0784325400943155 no 417 0.0686700936401726 325 17217378 SGTC_2058 5236698 133 µM 1.47944363207124 0.0793179815158418 no 418 0.0695108930267309 443 766665 SGTC_1962 st076595 64.5 µM 1.47817157634858 0.07949695269075 no 419 0.0696809298688208 448 279619 SGTC_370 0180-0345 38.7 µM 1.47120777680763 0.0804821402545866 no 420 0.0706174673416057 391 3989527 SGTC_526 4469-0568 170 µM 1.46866019452369 0.0808448487977759 no 421 0.0709624895834351 433 2901964 SGTC_2430 5571206 200 µM 1.46786299537505 0.0809586020747532 no 422 0.0710707208140056 497 1731771 SGTC_779 1360-0071 233 µM 1.45964585161907 0.082138165528918 no 423 0.0721937153934435 483 7566 SGTC_2596 sinensetin 100 µM 1.45901484271368 0.0822292787544009 no 424 0.0722805112539082 429 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3222 9128301 49.47 µM 1.45806653825986 0.0823663503462731 no 425 0.0724111017758013 436 4911358 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.45455844462356 0.0828749194650098 no 426 0.0728957711959192 426 5355888 SGTC_474 dl-dihydrosphingosine 5 µM 1.45037901622654 0.0834838916726828 no 427 0.073476427682599 456 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2034 5197015 53.07 µM 1.4415398941355 0.0847828818023574 no 428 0.0747161075880356 464 780676 SGTC_2851 9015922 71.43 µM 1.44127573535315 0.0848219342828523 no 429 0.0747533997659173 465 2996893 SGTC_1409 3909-8004 61.9 µM 1.43234237144161 0.0861505710167247 no 430 0.0760229312217782 473 2119279 SGTC_2721 ifenprodil 61.44 µM 1.43219060843934 0.0861732760683117 no 431 0.0760446393752748 451 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1082 camptothecin 424.86 nM 1.4309705988006 0.0863559626622591 no 432 0.0762193208302307 418 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2216 7189485 200 µM 1.42813243087966 0.0867820757153643 no 433 0.0766268722364707 418 731273 SGTC_2833 9001315 45.46 µM 1.42691745218198 0.0869649680612935 no 434 0.0768018448773958 488 2989378 SGTC_1468 k284-1086 134 µM 1.42426130028353 0.0873658046414077 no 435 0.0771854228563474 543 15996457 SGTC_350 k064-0020 19.8 µM 1.42360950962022 0.0874643759674142 no 436 0.0772797707463519 507 2790705 SGTC_2373 9071805 200 µM 1.42061379060883 0.0879184909147565 no 437 0.0777145335610106 431 10149009 SGTC_2138 5575593 77.673 µM 1.42008803971311 0.0879983694702755 no 438 0.0777910259033508 384 762213 SGTC_2816 7982706 58.44 µM 1.42007905365658 0.0879997352129451 no 439 0.0777923337956752 478 2981853 SGTC_2059 5238311 157 µM 1.41933247012455 0.0881132596647703 no 440 0.0779010549920708 448 703021 SGTC_229 benomyl 22.8748 µM 1.41376448355175 0.0889633655949525 no 441 0.078715532460021 501 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2513 baicalein 25.65 µM 1.4114361494714 0.0893206544566229 no 442 0.079058025100015 460 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1340 1486-1359 257 µM 1.41111994220901 0.0893692594922136 no 443 0.0791046253777829 468 4309068 SGTC_3109 9122853 49.47 µM 1.41110295195943 0.0893718716642685 no 444 0.0791071298633075 475 1234709 SGTC_1587 estradiol valerate 56.1 µM 1.4074143285853 0.0899403259951719 no 445 0.0796522824146806 482 13791 A steroid. SGTC_591 4299-0174 154 µM 1.40269922805796 0.0906708779053804 no 446 0.0803532738082922 463 5509088 SGTC_2945 9067681 61.76 µM 1.40048674462421 0.0910151916823611 no 447 0.0806838050234497 435 16456930 SGTC_2762 leflunomide 42.06 µM 1.39824260368591 0.0913654219045561 no 448 0.0810201135571312 522 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2147 5545932 89.7195 µM 1.39701581771706 0.0915573012196109 no 449 0.0812044072821153 455 797404 SGTC_3284 9108171 64.8615 µM 1.39698434327886 0.0915622280041135 no 450 0.0812091396826428 438 8687505 SGTC_1199 1638-0010 4.46 µM 1.39589788210756 0.0917324153634789 no 451 0.0813726242643756 520 3111136 SGTC_2343 7990716 14.84 µM 1.39563903118974 0.0917729972898725 no 452 0.0814116112920178 490 6456862 SGTC_3276 9139060 49.47 µM 1.39316239008378 0.0921619507477384 no 453 0.081785345012163 393 4870619 SGTC_2761 levamisole 97.89 µM 1.39288291949382 0.0922059177697299 no 454 0.0818275991579775 469 26879 An alkaline phosphatase inhibitor. SGTC_2485 5633444 17.78 µM 1.39213619537755 0.0923234704635176 no 455 0.0819405797271265 483 5724239 SGTC_2887 9044784 58.44 µM 1.38898862971563 0.0928201937275857 no 456 0.0824181037975573 492 6465546 SGTC_3300 9124615 50.48 µM 1.38613699060785 0.093271919973432 no 457 0.0828525385375269 472 24824903 SGTC_339 3091-4833 71.4 µM 1.38574693931562 0.093333833804429 no 458 0.0829120948418668 466 3240077 SGTC_102 gallobenzophenone 83.616 µM 1.38388703286122 0.0936294790807424 no 459 0.0831965239462267 514 70837 SGTC_646 4092-0839 27.3 µM 1.38276595301302 0.0938080163488524 no 460 0.0833683208645115 483 877796 SGTC_2958 9077254 16.72 µM 1.3793927154818 0.0943467359054865 no 461 0.0838868520063073 455 16457351 SGTC_1991 st073000 8.92 µM 1.37448989511649 0.0951337989138119 no 462 0.0846448225985054 556 4301969 YIL048W NEO1 SGTC_179 1273-0063 6.77 µM 1.36805358676013 0.0961743634567564 no 463 0.0856476516244949 439 3108139 SGTC_2872 9044037 25.97 µM 1.36799013930663 0.0961846625522434 no 464 0.0856575813379142 416 6465195 SGTC_426 0988-0037 14.6 µM 1.36396559211236 0.0968396042323175 no 465 0.086289197563412 568 5383008 SGTC_2213 7173844 200 µM 1.35569393553824 0.0981959769367258 no 466 0.0875982848865141 515 892728 SGTC_1047 2043-3044 82 µM 1.35321070450569 0.0986058765005084 no 467 0.0879941632354973 517 669592 SGTC_2333 9017922 200 µM 1.35141530186865 0.0989030174798373 no 468 0.0882812174030044 503 3163164 SGTC_920 mycophenolic acid 780.421 nM 1.33986491764202 0.100830293941266 no 469 0.0901446327720095 526 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1364 1653-0028 37.6 µM 1.33514135787761 0.101626298489924 no 470 0.0909150427870255 537 5718652 SGTC_2726 cimetidine 79.27 µM 1.33467648267407 0.101704884935837 no 471 0.0909911269055726 434 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2444 5485484 36.41 µM 1.33301047138994 0.101986885005584 no 472 0.0912641837356171 549 6790631 SGTC_752 1896-0090 130 µM 1.3308718707826 0.102349712091183 no 473 0.0916155871685495 525 772567 SGTC_1651 st011928 86.1 µM 1.33060768155225 0.102394598523055 no 474 0.091659066814574 521 720198 SGTC_1904 st060225 78 µM 1.33056067346147 0.102402586818883 no 475 0.0916668048982596 503 66595 SGTC_1092 toremifene 6.32 µM 1.32372264542358 0.103569436052334 no 476 0.0927975873739189 579 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2984 9022109 38.96 µM 1.32352905680686 0.103602610114727 no 477 0.0928297499693995 464 6459207 SGTC_2792 7535235 81.82 µM 1.32169206002408 0.103917788479718 no 478 0.0931353568467327 487 1281891 SGTC_2603 homopterocarpin 100 µM 1.31248995155562 0.105507087413373 no 479 0.0946774371320514 572 101795 A weak amylase inhibitor. SGTC_932 2857-0803 154 µM 1.31221905092652 0.105554139652274 no 480 0.0947231178541001 582 674898 SGTC_930 2810-3379 265 µM 1.30970099008265 0.105992223274945 no 481 0.09514850426027 605 1015764 SGTC_807 1315-0151 48 µM 1.30536032172298 0.106750479612622 no 482 0.0958850913161039 619 4011080 SGTC_1180 1193-0155 285 µM 1.3000077417458 0.107690883076716 no 483 0.0967991579002081 512 2921347 SGTC_2855 9016525 58.44 µM 1.2972765444908 0.108173024783568 no 484 0.0972680259190867 541 43811474 SGTC_837 0091-0265 12.5 µM 1.29615948110994 0.108370668458466 no 485 0.0974602729644157 580 759367 SGTC_3340 9146634 11.102 µM 1.29441036538006 0.108680663857724 no 486 0.0977618560882177 542 4907387 SGTC_2674 ligustilide 100 µM 1.29436109016527 0.108689406119831 no 487 0.0977703620344241 495 5319022 A signalling regulator. SGTC_2120 5538279 151.968 µM 1.29258432237871 0.10900497294657 no 488 0.0980774323851468 542 2058197 SGTC_686 1319-0111 510 µM 1.29116801627238 0.109256990458843 no 489 0.0983227115307944 595 4562600 SGTC_2776 terbinafine 19.92 µM 1.28609892378241 0.110162414559207 no 490 0.0992042698410116 534 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1721 st082152 9.2685 µM 1.28564359468223 0.110244006565556 no 491 0.0992837374480007 516 5296051 SGTC_1666 st014829 29 µM 1.2853489854646 0.110296821705223 no 492 0.0993351797538767 581 3858230 SGTC_190 3970-0790 3.722 µM 1.28252390698578 0.110804200190846 no 493 0.0998294620021368 511 2832352 SGTC_2044 5102272 200 µM 1.28021813789826 0.111219549490472 no 494 0.10023421432062 508 592666 SGTC_531 3788-1495 174 µM 1.27925022603966 0.1113942358901 no 495 0.100404477053477 554 2896655 SGTC_3185 9108267 49.47 µM 1.27741452298622 0.111726078376665 no 496 0.100727970077122 572 4910486 SGTC_1188 1403-0014 4.57 µM 1.27335579606281 0.112462288581597 no 497 0.101445907838578 628 9614867 SGTC_966 1300-0360 30.2 µM 1.27165881359473 0.112771128484095 no 498 0.101747185124005 576 70588 SGTC_2727 riluzole 51.77 µM 1.26515692801361 0.113960033644313 no 499 0.10290753955236 515 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3079 9117512 49.47 µM 1.26429138259131 0.114118974408508 no 500 0.10306273072755 571 7185044 SGTC_1044 1222-0021 1.78 µM 1.26360261775151 0.114245565589579 no 501 0.103186346775602 572 4306703 SGTC_2546 rhodinyl acetate 100 µM 1.26133101228099 0.11466378284954 no 502 0.103594806159196 589 6708682 SGTC_1127 asiatic acid 681.4 nM 1.25761666016109 0.115349964076144 no 503 0.104265212614379 563 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3171 9103192 49.47 µM 1.25632388787979 0.115589471262384 no 504 0.10449928224059 549 13018434 SGTC_2239 6685329 187.64 µM 1.25563765685689 0.115716750218476 no 505 0.104623685946105 578 805680 SGTC_2832 7992762 51.95 µM 1.25383774131517 0.116051063099634 no 506 0.10495049406918 501 2985177 SGTC_3092 9117248 49.47 µM 1.25335469756107 0.116140899298116 no 507 0.105038325284886 600 17141857 SGTC_94 0334-0113 514.748 µM 1.25248414867001 0.116302928086904 no 508 0.105196750375369 570 6795178 SGTC_2201 6605497 169.863 µM 1.25073313688119 0.116629316473359 no 509 0.105515928236789 544 670741 SGTC_2229 7354935 190 µM 1.24994006671571 0.116777358171932 no 510 0.105660720836467 511 318112 SGTC_849 0386-0493 241 µM 1.24975690636223 0.116811567479235 no 511 0.105694181243678 544 726119 SGTC_906 1165-0455 526 µM 1.2497409937436 0.116814539853313 no 512 0.105697088581041 569 3252859 SGTC_617 3770-0098 35 µM 1.24839964637696 0.117065287624957 no 513 0.105942369230225 550 5962639 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.24576420466906 0.117559060065377 no 514 0.106425487283738 569 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2084 5306078 60.6385 µM 1.24231753294553 0.118207045858459 no 515 0.107059714466575 569 679340 SGTC_561 1550-0330 72.9 µM 1.23769251943156 0.119080526338313 no 516 0.107915046969248 554 6812934 SGTC_2311 7694451 200 µM 1.23025269764222 0.120495154866128 no 517 0.109301245829738 598 2163142 SGTC_1243 0416-0003 5.65 µM 1.23006885433895 0.12053026054643 no 518 0.109335661000656 579 2141977 SGTC_1131 3454-3128 32.3 µM 1.22918688720829 0.120698776169274 no 519 0.109500872079422 640 710982 SGTC_584 0986-0246 15.4 µM 1.22847029577617 0.120835815873229 no 520 0.109635236742847 658 53315 YDR232W HEM1 SGTC_1436 4092-1007 8.32 µM 1.22785802449307 0.120952992295669 no 521 0.10975013457644 572 2881121 SGTC_2238 6671620 73.2395 µM 1.22538721696879 0.121426667482556 no 522 0.110214680480204 577 729941 SGTC_2655 perillic acid 100 µM 1.2223871337055 0.122003560582619 no 523 0.110780631233572 540 5702197 An apoptosis inducer. SGTC_2061 5245884 80.95 µM 1.22144288767456 0.122185529504733 no 524 0.110959188629728 619 573863 SGTC_18 0111-0177 500 nM 1.21936044235699 0.122587518050858 no 525 0.111353708520358 723 721752 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.21805170874834 0.122840626072698 no 526 0.111602161718365 583 756377 SGTC_529 4076-0302 30.3 µM 1.21752514133899 0.122942567100733 no 527 0.111702238379599 603 5816522 SGTC_1063 disulfiram 1.84 µM 1.21451299036692 0.12352684574204 no 528 0.112275946160797 603 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2687 chenodiol 100 µM 1.2144312452223 0.123542729225516 no 529 0.112291545001842 575 5702181 A cholesterol synthesis inhibitor. SGTC_3256 9138902 49.47 µM 1.21387119043865 0.12365158909447 no 530 0.112398457902455 604 17228773 SGTC_1725 st036284 20.55 µM 1.21381156040394 0.123663183554666 no 531 0.112409845392742 676 707914 SGTC_1752 st044819 83.042 µM 1.21372025604822 0.123680938243015 no 532 0.112427283294885 596 441209 YML126C ERG13 SGTC_450 aminopyrene 156 nM 1.21204582303795 0.124006858485734 no 533 0.112747420213081 628 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_124 0136-0217 7.121 µM 1.21027764331461 0.124351677985588 no 534 0.113086186702129 704 3976905 SGTC_1706 st031321 9.9705 µM 1.20986604821097 0.124432040842669 no 535 0.11316514853773 611 6103185 SGTC_1089 terbinafine 2.25 µM 1.20761826068317 0.124871556100613 no 536 0.113597065976636 595 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_440 fluspirilene 35.1 µM 1.2063991214328 0.125110390469231 no 537 0.113831817324831 615 3396 An atypical antipsychotic. SGTC_961 1252-1571 372 µM 1.20626820271862 0.125136056937277 no 538 0.11385704691814 626 6813498 SGTC_1815 st051655 58.2 µM 1.20354199189303 0.125671363215896 no 539 0.114383325874803 575 5984156 SGTC_2132 5317594 122.667 µM 1.20143457262574 0.12608625978445 no 540 0.114791335961601 555 794577 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.19768135213466 0.126827534950074 no 541 0.11552054586209 662 6708561 SGTC_1997 st073024 93.8 µM 1.1934838483509 0.127660145584391 no 542 0.11633996702772 620 686268 SGTC_1842 st055362 61.2 µM 1.18784745282897 0.128784138227232 no 543 0.117446757591576 674 676032 SGTC_285 1486-1325 46 µM 1.18695767196492 0.128962201111483 no 544 0.117622158501908 662 22310230 SGTC_1019 4262-0212 3.4 µM 1.18349952195818 0.129655866803558 no 545 0.118305617933094 710 4677213 SGTC_1079 idarubicin 2.36 µM 1.18303964841517 0.129748306540972 no 546 0.118396717182035 615 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3193 9111931 49.47 µM 1.18204517842353 0.12994836219501 no 547 0.118593887542104 638 17087244 SGTC_1502 4534-4282 27.7 µM 1.17985784150618 0.130389135709435 no 548 0.119028379907877 600 3278949 SGTC_162 k030-0015 37.8 µM 1.17886305186657 0.130589938972836 no 549 0.11922635619245 652 1809920 YMR134W ERG29 SGTC_2091 4-phenylthiadiazole 200 µM 1.17852927993644 0.130657360388027 no 550 0.119292833261287 649 270010 SGTC_572 0960-0087 17.7 µM 1.17432830865401 0.131508007988307 no 551 0.120131774301728 671 6796365 SGTC_1190 1486-1332 13 µM 1.17377992513003 0.131619330691906 no 552 0.120241593442765 629 4150046 SGTC_1113 artemisinin 1.17947 µM 1.17356117525493 0.131663755395539 no 553 0.120285419963994 676 2240 An anti-malaria and mitochondrial poison. SGTC_1270 0831-1170 17.3 µM 1.17355820997403 0.131664357669129 no 554 0.1202860141351 708 6764716 SGTC_2804 7954240 19.48 µM 1.17350464681601 0.131675237126181 no 555 0.120296747262115 677 828705 SGTC_1483 3453-0561 55.9 µM 1.17294426208801 0.131789096617885 no 556 0.120409079088159 684 4546991 SGTC_2170 morpholine 200 µM 1.17146491727534 0.132089997557445 no 557 0.120705975790716 661 121171 Reacts with secondary amines. SGTC_1129 3453-1384 223 µM 1.17083578771811 0.132218106909862 no 558 0.120832394831271 688 1084452 SGTC_2623 humulene 100 µM 1.17034718374368 0.132317660179946 no 559 0.120930640537803 557 6187145 An anti-inflammatory. SGTC_2107 5363541 170.161 µM 1.16900810841027 0.132590762138007 no 560 0.121200182262634 662 244052 SGTC_1908 st060353 56.5 µM 1.16822367782232 0.132750925565697 no 561 0.121358275981138 700 4227716 SGTC_2446 5162541 200 µM 1.16641658834076 0.133120400277807 no 562 0.121723027436841 612 1549321 SGTC_7 0192-1582 4.227 µM 1.16519882193092 0.133369781713731 no 563 0.12196926119827 759 252616 SGTC_1771 st048882 4.1505 µM 1.16221192547374 0.133982816351608 no 564 0.122574695862417 649 4580403 SGTC_3154 9100113 49.47 µM 1.15956324783776 0.134528051947824 no 565 0.123113335818736 653 25237525 SGTC_2462 5162487 171.77 µM 1.1543509430584 0.135605458261163 no 566 0.124178159388988 665 2259986 SGTC_223 busulfan 5 mM 1.15386866511844 0.135705445185461 no 567 0.124277008774857 561 2478 A DNA alkylator. SGTC_1983 st071813 46.9 µM 1.15371710349218 0.135736877701404 no 568 0.124308084742423 662 11838595 SGTC_970 1315-0089 19.5 µM 1.15276957792303 0.135933499002835 no 569 0.124502487154587 620 6811083 YLR033W RSC58 SGTC_1050 3232-1156 69.3 µM 1.15145614694954 0.136206371805027 no 570 0.12477231321281 649 700529 SGTC_2184 6075246 200 µM 1.14889927383558 0.136738651381641 no 571 0.125298758560466 655 2267320 SGTC_2733 amorolfine 100 µM 1.14591571782737 0.137361551750575 no 572 0.125915013513618 563 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2728 chlorpromazine 9.18 µM 1.14528043522191 0.137494434503781 no 573 0.126046503926541 555 2726 A thorazine and dopamine antagonist. SGTC_1957 st077035 62.4 µM 1.14237905075421 0.13810243571665 no 574 0.126648247645821 667 705593 SGTC_1455 4262-0120 131 µM 1.13727310284785 0.139176862011224 no 575 0.127712067605173 701 1529587 SGTC_606 k015-0008 38.6 µM 1.13562678804543 0.139524499738279 no 576 0.12805639635751 741 1970475 SGTC_1178 0988-0033 191 µM 1.13355921413648 0.139961926952261 no 577 0.128489744770398 698 5392207 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.12791132159926 0.141161571910956 no 578 0.129678685999152 702 4213774 SGTC_999 SEC7.066 22.7 µM 1.12417127884541 0.141959804718319 no 579 0.130470185651371 735 740511 YDR170C SEC7 SGTC_2537 larixol 68.93 µM 1.12132249498094 0.142569863774077 no 580 0.131075306832183 741 6708759 SGTC_560 2332-1943 155 µM 1.12068271277162 0.142707114764347 no 581 0.131211471626176 689 21177716 SGTC_258 haloperidol 50.781 µM 1.11985157183256 0.142885550861606 no 582 0.131388509134455 669 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_101 0490-5701 117.494 µM 1.11707761837058 0.14348217685359 no 583 0.131980569646672 630 4661669 SGTC_1572 epiandrosterone 68.9 µM 1.11500130951052 0.143929851438204 no 584 0.132424930283615 745 441302 A steroid. SGTC_1421 4029-0249 71.4 µM 1.11336908138547 0.144282438185416 no 585 0.132774974149235 769 2894095 SGTC_1239 0337-0584 35.4 µM 1.10936322614321 0.145150231547363 no 586 0.133636759856663 756 914301 YML130C ERO1 SGTC_781 4335-2806 94.4 µM 1.10706411077558 0.145649875020006 no 587 0.134133105454896 798 845254 SGTC_933 2914-0560 114 µM 1.10437252182247 0.146236278445466 no 588 0.134715787711624 760 463887 SGTC_1093 fluphenazine 7.97 µM 1.10169440059024 0.146821319321276 no 589 0.13529727605048 730 6602611 An atypical antipsychotic. SGTC_2508 celastrol 40.54 µM 1.10070365474651 0.14703814703121 no 590 0.135512827551146 635 122724 Celastrol is a natural product and antioxidant. SGTC_1719 st032227 49.2 µM 1.09414938088771 0.148477976737422 no 591 0.136944733926331 686 3125804 SGTC_2533 agelasine 13.65 µM 1.09379374952748 0.148556369872954 no 592 0.137022723041238 742 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1591 genipin 88.4 µM 1.0903902545453 0.14930801448967 no 593 0.137770636450239 689 442424 A DNA cross-linking agent. SGTC_2913 7966556 36.57 µM 1.08939571980753 0.14952813100245 no 594 0.137989709041175 675 2976516 SGTC_2465 5809242 33.21 µM 1.08872348920945 0.149677035794461 no 595 0.138137920123972 717 2731748 SGTC_1951 sophoraflavanone G 9.2 µM 1.0885643338129 0.149712304547218 no 596 0.138173026042866 745 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3076 9116187 49.47 µM 1.08624492626997 0.150226913172822 no 597 0.138685322848506 660 27241210 SGTC_1760 st045453 10.4495 µM 1.08333086125815 0.150875128055098 no 598 0.139330795885562 757 3323419 YIL048W NEO1 SGTC_755 1995-0008 37.3 µM 1.08267877959633 0.151020433943555 no 599 0.139475513094015 748 689533 SGTC_119 0121-0043 24.815 µM 1.08073760971569 0.151453543457292 no 600 0.139906924117253 874 1092378 SGTC_901 1112-0062 60.1 µM 1.07783329828785 0.152103087759762 no 601 0.140554078313014 703 1908457 SGTC_1384 3089-0840 101 µM 1.0768762219551 0.152317540917935 no 602 0.140767783617506 685 1069836 SGTC_1229 0139-0193 12.2 µM 1.07660095043901 0.152379258460487 no 603 0.140829289721241 774 3090752 SGTC_1672 st016598 6.51 µM 1.07092321639627 0.153655942520885 no 604 0.142101977955625 715 4665860 YNL267W PIK1 SGTC_750 4073-0104 132 µM 1.06706689320002 0.154527094891817 no 605 0.14297081519419 621 22330957 SGTC_1790 st045711 43.5 µM 1.06675530371657 0.154597625946836 no 606 0.143041173327194 724 585119 SGTC_3053 9095903 49.47 µM 1.0667294242977 0.154603484940592 no 607 0.143047018053952 746 17174018 SGTC_2830 7992007 71.43 µM 1.0653213845413 0.15492248052964 no 608 0.143365259439548 710 1952075 SGTC_2981 9013952 38.96 µM 1.06209605957167 0.155654824750202 no 609 0.144096039391435 670 2996344 SGTC_396 dithiazanine 1.25 µM 1.06120857607946 0.155856737201037 no 610 0.14429756139411 692 10578 An antihelmenthic. SGTC_2297 7971671 152.32 µM 1.05990688100671 0.15615319966744 no 611 0.144593482452476 726 909016 SGTC_1916 st067606 49.2 µM 1.05759405738664 0.156680863759752 no 612 0.145120276472952 780 19590279 SGTC_1141 3253-0389 52.6 µM 1.05183133510907 0.158000711816876 no 613 0.146438469878793 739 5402031 SGTC_2789 5281112 71.43 µM 1.05172262535311 0.158025679778353 no 614 0.14646341368642 726 765948 SGTC_816 0325-0417 81.3 µM 1.05016314290253 0.158384139686003 no 615 0.146821555948395 732 68101 SGTC_3088 9117578 49.47 µM 1.04496782180819 0.159582172768551 no 616 0.148018920922431 755 678341 SGTC_44 0929-0055 61.211 µM 1.04482109705462 0.159616093164411 no 617 0.148052831183606 697 1379590 SGTC_1507 4075-3230 155 µM 1.04478736574438 0.159623891966168 no 618 0.148060627723401 680 659771 SGTC_155 k072-0202 43.6 µM 1.04288488835075 0.160064155321631 no 619 0.148500804652402 738 5857737 SGTC_2391 6285546 200 µM 1.04161224144421 0.160359108736274 no 620 0.148795745442908 780 846083 SGTC_3156 9099931 49.47 µM 1.03937031559484 0.160879569280503 no 621 0.149316272028313 797 18111053 SGTC_475 α-linolenic acid 10 µM 1.03923659151158 0.160910647985129 no 622 0.149347358235732 807 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2224 6650123 117.647 µM 1.03500340151966 0.161896505741014 no 623 0.150333661327532 725 2908370 SGTC_2069 5228469 200 µM 1.03406087546242 0.162116542935421 no 624 0.150553852616195 730 2835210 SGTC_112 phenothiazine 287.218 µM 1.03045450832716 0.162960263821856 no 625 0.151398348398557 807 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2891 9063876 19.48 µM 1.02660584780198 0.163863813177151 no 626 0.152303049658891 716 6472478 SGTC_2658 polymyxin b sulfate 77.05 µM 1.02567532196949 0.164082759696489 no 627 0.152522325186586 783 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2869 9037858 32.47 µM 1.02172680768871 0.165013928750045 no 628 0.153455109705016 726 27187042 SGTC_399 oxolinic acid 75 µM 1.01969023245079 0.16549554447308 no 629 0.153937697761049 763 4628 A DNA gyrase inhibitor. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.01878645788058 0.165709562915738 no 630 0.154152178089658 838 66535 A nucleotide analog. SGTC_900 1112-0045 141 µM 1.01783689239359 0.165934617574183 no 631 0.15437773818738 653 56211 YIL048W NEO1 SGTC_3243 9134147 49.47 µM 1.01750996845244 0.166012146868924 no 632 0.154455446280415 824 24282180 SGTC_1891 st059073 26.2 µM 1.01693154871398 0.166149375173169 no 633 0.154592996932443 857 688754 SGTC_2685 mycophenolic acid 18.85 µM 1.01553976227523 0.166479872429587 no 634 0.154924301277495 778 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_674 0498-0004 451 µM 1.01450098303842 0.166726820069138 no 635 0.15517188029201 754 4231473 SGTC_3099 9120367 49.47 µM 1.01355751878045 0.16695131332116 no 636 0.15539696848375 786 24824940 SGTC_1801 st050089 28.441 µM 1.01080289293579 0.167607879651576 no 637 0.156055389120581 873 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2802 7925815 54.55 µM 1.00989285343067 0.167825152972814 no 638 0.156273313488376 783 1262923 SGTC_751 0833-0568 350 µM 1.00506446417443 0.1689809700153 no 639 0.157432904981659 789 6954252 SGTC_2951 9072950 58.06 µM 1.00504040825731 0.168986741277609 no 640 0.157438696400243 875 16488155 SGTC_3308 9128332 17.569 µM 1.00460832232258 0.169090424703789 no 641 0.157542744153093 872 17332805 YDL196W YDL196W SGTC_2729 fluphenazine 10.66 µM 1.00374407888894 0.169297931277078 no 642 0.157750992434225 820 3372 An atypical antipsychotic. SGTC_254 nsc-64875 3.808 µM 1.00116409169624 0.16991836324486 no 643 0.158373741768684 823 56993 SGTC_248 streptozotocin 5.23457 mM 1.000238820297 0.170141225994322 no 644 0.158597473311577 847 5300 DNA alkylating agent. SGTC_157 1348-1695 65.819 µM 0.996924911241263 0.170940956852692 no 645 0.159400479442824 817 5380510 SGTC_520 3584-0023 682 µM 0.996206882801171 0.171114551931961 no 646 0.159574817949771 746 1340790 SGTC_2163 5671233 125 µM 0.99497360713779 0.171412979458922 no 647 0.159874550490993 857 701023 SGTC_1373 2887-0003 58.5 µM 0.990635737668988 0.172465296202876 no 648 0.160931740251854 775 776948 SGTC_2478 5763493 32.33 µM 0.989198910798933 0.172814760195587 no 649 0.161282915615192 835 1365576 YLR208W SEC13 SGTC_2363 9053361 176 µM 0.988789152015078 0.172914504077874 no 650 0.161383156438514 811 6469797 YMR079W SEC14 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.984055384874441 0.174069461109075 no 651 0.162544140897733 814 2333 A French combination drug. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.984027959176894 0.174076166759651 no 652 0.162550883007523 830 688667 SGTC_2822 7994718 71.43 µM 0.976787282055428 0.175852272910423 no 653 0.164337236805201 732 1018011 SGTC_1605 st000082 49.1 µM 0.976371675387627 0.175954566511213 no 654 0.164440156295009 840 1114022 SGTC_651 3253-0966 34.4 µM 0.972355425629277 0.176945029962546 no 655 0.165436879515185 853 781462 SGTC_2250 alverine citrate 130 µM 0.970084266512634 0.177506686057129 no 656 0.166002245376722 878 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1617 st002906 78 µM 0.96906078963563 0.177760158593406 no 657 0.166257429881927 856 5150859 SGTC_2911 7942208 15.64 µM 0.968374535215773 0.177930243008151 no 658 0.166428676194456 775 1243384 SGTC_2714 st079313 56.9 µM 0.968077001625237 0.178004016969279 no 659 0.166502957404394 828 2939799 SGTC_1041 0206-0046 107 µM 0.96686113433159 0.178305693749144 no 660 0.166806729029888 829 50494 SGTC_1724 st037281 8.293 µM 0.965934892271602 0.178535725789015 no 661 0.167038380627554 809 574124 YDL195W SEC31 SGTC_993 3909-8757 62.7 µM 0.964992876336102 0.178769866893101 no 662 0.16727418992093 767 4288324 YLR208W SEC13 SGTC_3143 9086658 49.47 µM 0.963118932055523 0.179236216251757 no 663 0.167743920968985 894 25236626 SGTC_801 0866-0028 10.1 µM 0.963009905785693 0.179263372036719 no 664 0.167771276091058 858 6849771 SGTC_1763 st044482 94.5 µM 0.961191668443365 0.179716631951464 no 665 0.168227902381804 859 88505 SGTC_3234 9132280 49.47 µM 0.959616400469996 0.180109904776888 no 666 0.168624155891599 828 17612295 SGTC_3135 9127742 49.47 µM 0.957833291244732 0.180555717464622 no 667 0.169073414490613 790 3643468 SGTC_2949 9072542 2.23 µM 0.956394580311341 0.180915927780996 no 668 0.169436460917205 840 16457352 SGTC_1615 st002656 86.5 µM 0.953304264706985 0.181691172023962 no 669 0.17021796566404 844 1584458 SGTC_2878 9043973 25.97 µM 0.95152089302463 0.182139497483935 no 670 0.170670008818348 825 6465167 SGTC_869 0564-0080 44.1 µM 0.948665754205491 0.182858695023757 no 671 0.171395318358756 835 6843321 SGTC_667 1498-1044 59 µM 0.947771163465272 0.183084402885949 no 672 0.171622981863129 884 6739982 SGTC_1221 2958-7315 257 µM 0.946480295157252 0.183410398928631 no 673 0.171951834015213 820 4562705 SGTC_1805 st050013 60.3 µM 0.944028091286091 0.184030674709367 no 674 0.172577646720598 833 4037144 SGTC_3083 9117465 49.47 µM 0.94038341138602 0.184954992681923 no 675 0.173510464044553 867 16420915 SGTC_774 k060-0086 136 µM 0.940373509268204 0.184957507855676 no 676 0.173513002750033 938 5911235 SGTC_2148 5546263 113.568 µM 0.939634216539174 0.185145350907482 no 677 0.173702609424215 862 792097 SGTC_187 1488-2104 32.728 µM 0.937716859012365 0.185633074237913 no 678 0.174194968753956 902 2852859 SGTC_1818 st052136 56.3 µM 0.937035849350146 0.185806496158123 no 679 0.174370058861926 821 674169 SGTC_2261 9010538 184.68 µM 0.935732265383897 0.186138739361157 no 680 0.174705526855917 751 6457250 SGTC_994 3910-0338 138 µM 0.935448905716755 0.186211007659032 no 681 0.17477850161343 899 3479481 SGTC_2993 9054257 71.4286 µM 0.933943761629993 0.186595172337811 no 682 0.175166451723123 883 6470217 YGL055W OLE1 SGTC_3115 9123671 49.47 µM 0.932326172920466 0.187008583442231 no 683 0.175583992783474 943 3286988 SGTC_1408 3909-7976 48.8 µM 0.932189993776151 0.187043412920279 no 684 0.175619172868502 908 24152374 SGTC_1218 1348-1416 30.7 µM 0.93122697037348 0.187289832420178 no 685 0.175868084720875 876 6787668 SGTC_1070 indatraline 8.81 µM 0.929353225862435 0.18776986312629 no 686 0.176353029842768 867 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1359 1582-0056 520 nM 0.929231910353743 0.187800968864577 no 687 0.176384456729439 933 3661189 SGTC_1978 st071761 42 µM 0.928234561478798 0.188056813360282 no 688 0.176642955098018 835 5147680 SGTC_2215 7188065 200 µM 0.927805872249343 0.188166848761493 no 689 0.176754138705234 851 940217 SGTC_1160 4092-0570 10.5 µM 0.927417280070297 0.188266626427009 no 690 0.176854961075532 872 4994975 SGTC_1086 cerivastatin 2.18 µM 0.925147068409911 0.188850194160039 no 691 0.177444706200351 865 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2079 5212404 121 µM 0.924651453493328 0.1889777421955 no 692 0.177573619668688 917 758462 SGTC_1458 k015-0034 6.33 µM 0.924553825205469 0.18900287339305 no 693 0.177599020546487 842 3598957 SGTC_374 0880-0231 82.3 µM 0.924330228658407 0.189060438739804 no 694 0.177657204420329 896 6833587 SGTC_2875 9039966 71.43 µM 0.921790964859948 0.189714934377088 no 695 0.178318810590151 905 6463691 SGTC_2368 9071271 200 µM 0.921738173791722 0.189728556053536 no 696 0.178332581777278 860 27209959 SGTC_1184 1269-1718 139 µM 0.920111965322353 0.190148461158098 no 697 0.178757126116186 905 5403821 SGTC_1194 1488-0194 225 µM 0.919924000764489 0.190197032486143 no 698 0.178806237867727 902 1391452 SGTC_2610 ononetin 44.17 µM 0.919266008200859 0.190367122308914 no 699 0.178978226366617 877 259632 SGTC_1701 st028638 40.4 µM 0.916376175812764 0.191115244025461 no 700 0.17973481328021 912 3490878 SGTC_2135 5326629 150.42 µM 0.915163383195425 0.191429748892215 no 701 0.18005293218902 838 5020077 SGTC_1550 gossypolone 36.6 µM 0.911339382160873 0.192423474479209 no 702 0.181058291084225 941 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2264 7948757 110.76 µM 0.910511704399736 0.19263897379309 no 703 0.181276355976723 859 2971411 SGTC_2665 lovastatin 100 µM 0.906896678949547 0.193581932002001 no 704 0.182230718776724 881 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_37 0566-0070 1.56 µM 0.905199357852691 0.194025637733755 no 705 0.1826798910073 952 1626686 SGTC_3282 9108498 15.4605 µM 0.904334319828926 0.194252010104968 no 706 0.182909076894525 856 16459645 SGTC_613 3914-0030 117 µM 0.902186308797837 0.194814819688996 no 707 0.183478953254414 695 1145395 SGTC_3323 9138564 53.9225 µM 0.901443547763388 0.195009664235617 no 708 0.183676268119058 989 43912313 YNL103W MET4 SGTC_249 wiskostatin 11.211 µM 0.898568848451945 0.195764884740502 no 709 0.184441178886762 928 2775510 A n-wasp and actin depolymerizer. SGTC_3299 9121982 43.1275 µM 0.898135692017418 0.195878834207601 no 710 0.184556606315283 907 17594604 YPL160W CDC60 SGTC_2092 5303694 80.6725 µM 0.894551432539433 0.1968232806733 no 711 0.185513462058184 904 1963699 SGTC_2190 6049624 200 µM 0.893511888948836 0.197097713689579 no 712 0.185791554113517 864 2265554 SGTC_2289 7946404 165.07 µM 0.893202437726448 0.197179451583764 no 713 0.185874386442655 960 1246120 YPR165W RHO1 SGTC_35 0133-0054 64.071 µM 0.892267547103255 0.197426516475785 no 714 0.186124772290131 862 99677 SGTC_1318 1280-3875 124 µM 0.891096672655166 0.197736209062199 no 715 0.186438654912752 911 373245 SGTC_1736 st036774 51 µM 0.890867360598712 0.197796895734616 no 716 0.186500166204108 966 1272247 SGTC_707 0865-0008 204 µM 0.888813936045285 0.198340829134406 no 717 0.187051542458121 980 723043 SGTC_883 0850-0245 24.6 µM 0.887132723177481 0.198786838432769 no 718 0.187503724063918 952 6823229 YPR165W RHO1 SGTC_305 1682-2595 20.8 µM 0.883247223989746 0.199819934217273 no 719 0.188551355826526 943 226033 SGTC_1136 pergolide 1.05886 µM 0.882226950201516 0.200091744056833 no 720 0.188827045363032 934 47811 A dopamine receptor agonist. SGTC_2990 9074105 71.4286 µM 0.881021748508785 0.200413106473837 no 721 0.189153024348783 926 6502001 SGTC_171 k064-0041 9.68 µM 0.880431582621401 0.200570584962593 no 722 0.189312776793457 842 53325 SGTC_3026 9090633 49.47 µM 0.879542154535791 0.200808058201697 no 723 0.189553693599476 955 25236842 SGTC_1054 3429-0080 167 µM 0.878592620847307 0.201061765503341 no 724 0.189811099117394 965 1162877 SGTC_302 1094-0063 18.9 µM 0.878151723419694 0.201179634868249 no 725 0.189930693382112 867 5440289 SGTC_2097 5376186 200 µM 0.878057881021849 0.201204728009316 no 726 0.189956154288714 942 742755 SGTC_2521 angolensin 13.4 µM 0.877787508636078 0.201277035166421 no 727 0.190029522265172 913 821428 A flavenoid. SGTC_3122 9126309 49.47 µM 0.876037378877143 0.201745458552498 no 728 0.190504856843941 1008 17591206 SGTC_3320 9137005 35.139 µM 0.874719292689603 0.20209867581195 no 729 0.190863330057841 874 4908713 SGTC_772 k072-0172 35.3 µM 0.871900031006476 0.202855415279839 no 730 0.191631458391739 872 5861980 SGTC_226 1,3-diallylurea 8.28947 mM 0.868411623968821 0.203794104399413 no 731 0.192584516843649 916 74537 YKL182W FAS1 SGTC_1080 nisoldipine 24.4 µM 0.867789105931201 0.203961888490504 no 732 0.192754897475488 951 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_688 0527-0193 473 µM 0.867786968755011 0.203962464654371 no 733 0.19275548257043 911 4007154 SGTC_1473 k844-0725 134 µM 0.866642813425349 0.204271058067536 no 734 0.193068873867459 1053 54682906 SGTC_15 0266-0086 27.098 µM 0.866005519646148 0.204443064885351 no 735 0.193243567439625 1034 1712902 YIL048W NEO1 SGTC_1146 3579-1023 7 µM 0.863359282503759 0.205158211018889 no 736 0.193969979572171 1014 X1146 SGTC_1945 st075991 56.6 µM 0.862519357551911 0.205385511335201 no 737 0.19420089276911 855 1084980 SGTC_2906 7926292 26.41 µM 0.860533040540291 0.205923642778115 no 738 0.194747639228412 971 2966319 SGTC_287 k060-0039 29.6 µM 0.859070817192269 0.20632032111239 no 739 0.195150723303241 984 5861974 SGTC_1422 4031-0024 15.5 µM 0.859012429915627 0.20633617006459 no 740 0.195166829163735 946 782427 SGTC_885 0865-0106 16.8 µM 0.85693528664686 0.2069004701222 no 741 0.195740324984221 992 2793380 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.854019760650483 0.20769407355842 no 742 0.196547020265342 1036 551469 SGTC_1295 1013-0063 9.78 µM 0.853557683270499 0.20782001547196 no 743 0.196675056875478 989 6826038 SGTC_2848 9016370 25.97 µM 0.852427199849759 0.208128325482664 no 744 0.196988514451054 1004 7894410 SGTC_22 0964-0034 14.468 µM 0.849545540885712 0.208915443178929 no 745 0.197788900287179 1008 138402 SGTC_1734 st037168 69.4 µM 0.848113110503388 0.20930735944966 no 746 0.19818749043061 933 708907 SGTC_2028 5153890 36.43 µM 0.847846907013905 0.209380240992262 no 747 0.198261617993555 946 2830968 YPR165W RHO1 SGTC_1482 3346-2049 8.48 µM 0.847373830414853 0.209509797372319 no 748 0.198393393150534 967 3826804 SGTC_1463 k081-0032 34.1 µM 0.846564968326045 0.209731420913939 no 749 0.198618823515556 848 977755 SGTC_1378 2093-0007 380 nM 0.842522399737137 0.210841125561659 no 750 0.199747803474328 953 3618014 SGTC_682 0kpi-0099 17 µM 0.841647646466681 0.211081701939491 no 751 0.199992605477727 989 1714895 YML126C ERG13 SGTC_1917 st066507 28.5 µM 0.840748236203945 0.211329227211192 no 752 0.200244495797459 982 3156428 SGTC_1355 1499-0035 1.68 µM 0.840620998524663 0.211364257814046 no 753 0.200280145577663 966 1548538 SGTC_2443 5493264 126.67 µM 0.840060645238948 0.21151857265618 no 754 0.200437192176102 992 5340055 SGTC_1768 st044301 37.178 µM 0.839379768878635 0.211706166911366 no 755 0.200628116508028 1040 3931349 SGTC_1665 st014639 11.4 µM 0.836707321875688 0.21244341689909 no 756 0.2013785512529 1046 981133 YIL048W NEO1 SGTC_1357 1503-1303 39.5 µM 0.836481826650047 0.212505692986016 no 757 0.201441948168582 1023 292895 SGTC_1611 st001856 99.4 µM 0.83637598413434 0.212534927693149 no 758 0.201471709415204 947 647478 SGTC_2719 novobiocin 32.65 µM 0.83583408366827 0.212684642543411 no 759 0.201624124556689 952 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2137 5261020 140 µM 0.835810731313736 0.212691095654873 no 760 0.201630694201271 962 763655 SGTC_2082 5219693 150 µM 0.833375637049676 0.213364628737832 no 761 0.202316455253846 1019 2834649 SGTC_469 w7 172 µM 0.831956226771676 0.213757802420117 no 762 0.202716826379513 1004 45115570 A P450 inhibitor. SGTC_2334 9017922 200 µM 0.830074284826476 0.214279746499343 no 763 0.203248392564919 1016 3163164 SGTC_1175 0741-0056 27.6 µM 0.829514920304014 0.214435025333817 no 764 0.203406548785052 1073 765927 SGTC_3034 9090421 49.47 µM 0.828048578995524 0.214842390141446 no 765 0.203821494421847 959 17173761 SGTC_2183 6420625 130.508 µM 0.826682333781677 0.215222351478634 no 766 0.204208568534168 1058 2897619 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.824496434597575 0.215831074187036 no 767 0.2048287704133 951 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3289 9119912 71.43 µM 0.824264744304222 0.215895653044462 no 768 0.204894573143202 997 17014829 SGTC_2207 7258803 200 µM 0.824018981391069 0.215964166588349 no 769 0.204964386396319 973 3666799 SGTC_2787 5284540 71.43 µM 0.823643604692351 0.216068838046543 no 770 0.205071046002928 976 736958 SGTC_2815 7968870 71.43 µM 0.822538902247314 0.216377047884623 no 771 0.205385127702506 1021 2977326 YHR190W ERG9 SGTC_1977 st070720 65.3 µM 0.822066427099314 0.216508945184674 no 772 0.205519545894543 945 682188 SGTC_2424 5537928 59.2 µM 0.816730634661095 0.218001723831728 no 773 0.207041190169881 1064 5382802 SGTC_2117 5521686 200 µM 0.816215512411144 0.21814615145118 no 774 0.207188443078349 986 803312 SGTC_3138 9097216 49.47 µM 0.811305821217884 0.21952547305807 no 775 0.208595033960239 1070 25237486 SGTC_97 0535-0701 19.132 µM 0.810260324789523 0.219819838972032 no 776 0.208895286511521 979 2832013 YGL099W LSG1 SGTC_1567 st069303 68.4 µM 0.804836586954509 0.221350557253257 no 777 0.210456992804918 1039 5581319 SGTC_1727 st034309 9.9045 µM 0.804338973204865 0.221491301275255 no 778 0.210600617683128 1085 870305 SGTC_2351 9026858 72.31 µM 0.804080228731046 0.22156450422731 no 779 0.210675321105935 995 1409300 SGTC_291 SEC14.278 35.5 µM 0.803345009649002 0.221772584923771 no 780 0.210887674745761 1053 1068044 SGTC_1963 st076565 50.3 µM 0.802885663919834 0.221902644963352 no 781 0.211020411448937 1049 4914280 SGTC_2939 9044578 71.43 µM 0.801981569164402 0.2221587593008 no 782 0.211281809873184 1021 2653634 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.801636545686861 0.222256542916097 no 783 0.21138161554847 965 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2526 patulin 37.61 µM 0.801012769283232 0.22243339063073 no 784 0.211562126750018 1059 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_224 benfluorex 43.875 µM 0.797521774473314 0.223424607612832 no 785 0.212574030986965 1039 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2307 7538926 6.34 µM 0.79658272770861 0.223691664512992 no 786 0.212846705981165 1035 96582 SGTC_3038 9091290 49.47 µM 0.796383952352468 0.223748217797111 no 787 0.212904451395119 1035 25236843 SGTC_1425 4048-4433 7.33 µM 0.796332661373838 0.223762811837125 no 788 0.212919353210927 1103 23734946 SGTC_619 1652-1634 108 µM 0.795352652560261 0.22404176183202 no 789 0.213204196808694 967 5400454 SGTC_1252 0493-0875 34.8 µM 0.793810896294017 0.224481007385435 no 790 0.213652764146558 1020 3960963 SGTC_1071 trifluoperazine 6.31 µM 0.793458682826524 0.224581421344954 no 791 0.213755316230835 1072 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1170 0310-0127 64.8 µM 0.793400106097227 0.224598123692234 no 792 0.213772374479365 1049 774975 SGTC_2915 7971052 15.16 µM 0.790899066838075 0.225311917628465 no 793 0.214501446495121 926 5741558 SGTC_2482 5981709 142.65 µM 0.790253704785233 0.225496311560804 no 794 0.214689808831847 1024 877755 SGTC_2514 salinomycin 42.74 µM 0.788325836727547 0.226047653672475 no 795 0.215253069362471 1115 23682228 A polyether potassium ionophore. SGTC_3046 9092212 49.47 µM 0.787729228809291 0.226218429087932 no 796 0.215427552466039 1043 25236637 SGTC_2280 7785178 200 µM 0.786906181767583 0.226454140938884 no 797 0.215668394252309 1021 2954328 SGTC_921 1561-0023 372 µM 0.786722841624446 0.226506666471965 no 798 0.215722064889666 1120 24050882 SGTC_488 nitrendipine 139 µM 0.78523699969117 0.22693260237296 no 799 0.216157312924151 1075 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1354 1498-1681 81 µM 0.782819328298093 0.227626623861705 no 800 0.216866607849426 1092 5754243 SGTC_1139 k015-0024 46.9 µM 0.782094616392293 0.227834893637265 no 801 0.21707948520535 1084 2766652 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.779647987887411 0.2285388042277 no 802 0.217799050742727 1098 688788 SGTC_1268 0828-0275 2.46 µM 0.775820454461454 0.229642456429566 no 803 0.218927502478434 1102 745337 SGTC_3008 9078912 71.4286 µM 0.774762986909392 0.229947898001654 no 804 0.219239862066167 1061 16648731 SGTC_313 3474-0040 5.03 µM 0.771792129890841 0.230807223394836 no 805 0.220118776876476 1082 1043375 YIL048W NEO1 SGTC_3062 9077494 49.47 µM 0.771239001196894 0.230967414617321 no 806 0.220282640418683 1035 16459633 SGTC_1521 st012942 49.4 µM 0.770957938941364 0.231048836641125 no 807 0.220365931479885 1105 24207259 SGTC_2806 7952793 58.44 µM 0.770806202278046 0.231092800486824 no 808 0.220410905204563 1073 2972490 SGTC_1445 4239-0156 97.7 µM 0.769349327538149 0.231515149677721 no 809 0.220842980721226 1137 4008346 SGTC_1156 4092-0367 4.88 µM 0.766811557532564 0.232251877898601 no 810 0.221596781864481 1091 1357585 SGTC_2980 9014342 25.29 µM 0.766497689519312 0.232343086023579 no 811 0.221690113056053 1026 2996599 SGTC_45 0kpi-0036 14.9 µM 0.764659426879958 0.232877673812409 no 812 0.222237186101029 1067 2795021 SGTC_79 0052-0007 94.094 µM 0.764180947123172 0.233016933189181 no 813 0.222379709509489 1088 2801472 SGTC_2339 9000433 200 µM 0.76188912978985 0.233684597138189 no 814 0.223063089129357 1051 2988954 SGTC_2301 7769476 200 µM 0.759524273379824 0.234374649575287 no 815 0.223769499697827 1078 977820 SGTC_1677 st019204 53.9 µM 0.75775958493051 0.234890310020278 no 816 0.224297460509798 1019 3945625 SGTC_1876 myriocin 605 nM 0.755702956916589 0.235492068611432 no 817 0.224913655414642 1112 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1013 4112-3890 241 µM 0.75455879515726 0.235827212262141 no 818 0.225256877488509 1036 705171 SGTC_1449 4112-4002 201 µM 0.75365259327693 0.236092840079169 no 819 0.225528927485047 1088 2059539 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.753288801562357 0.236199521828097 no 820 0.225638193335711 1096 616764 SGTC_2784 7567673 72.73 µM 0.753013068366749 0.236280398142574 no 821 0.225721030517466 1139 3471247 SGTC_1797 st048695 56.8 µM 0.75182218892914 0.236629874448119 no 822 0.226078998172614 1089 592262 YIL048W NEO1 SGTC_2115 tiliquinol 12.7705 µM 0.750879489397681 0.236906721236535 no 823 0.226362592561824 1080 71208 A bioactive hydroxyquinoline. SGTC_815 1582-0027 36.9 µM 0.750069267715806 0.237144804878539 no 824 0.22660649381663 1124 3128206 SGTC_1200 1643-0193 18.4 µM 0.749356837257521 0.237354261135697 no 825 0.226821079460751 1146 5403974 SGTC_2049 5262831 67.185 µM 0.747762928672749 0.23782324172716 no 826 0.227301583185015 1112 763417 SGTC_421 streptovitacin 30 mM 0.747003751815549 0.238046795198329 no 827 0.227530648067087 1117 91467 include heat shock SGTC_2182 6325192 200 µM 0.741696689629979 0.239612768714415 no 828 0.22913556297668 1085 736248 SGTC_1106 tegaserod maleate 11.7 µM 0.73948078708696 0.240268283150396 no 829 0.229807551057064 1128 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2251 lansoprazole 556 µM 0.739275909692717 0.240328939859759 no 830 0.229869737251352 963 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3176 9106582 49.47 µM 0.738859518482296 0.240452243783979 no 831 0.22999615301022 1039 17018027 SGTC_2884 9058502 51.95 µM 0.738125812093988 0.240669596541469 no 832 0.230218999841655 1138 6471554 SGTC_228 caffeine 993.056 µM 0.736914878631277 0.241028556550816 no 833 0.230587057684321 1100 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1396 3511-0007 98.6 µM 0.736135834810573 0.241259644252934 no 834 0.230824018300644 1080 X1396 SGTC_1401 3807-4679 7.6 µM 0.735835666106429 0.241348715393408 no 835 0.230915356456383 1103 3291456 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.735616683288406 0.241413706953071 no 836 0.230982003336397 1135 97141 SGTC_1005 4092-0690 4.4 µM 0.735315351983511 0.241503154128073 no 837 0.231073730327165 1104 1529343 SGTC_227 fluconazole 33.516 µM 0.734978354785686 0.241603209682439 no 838 0.231176338299405 1140 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1090 efavirenz 20.7 µM 0.734884331648341 0.241631129470247 no 839 0.231204970738838 1127 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2389 9091542 195.52 µM 0.734559230163661 0.241727680530318 no 840 0.231303987665434 1089 3626624 YOL127W RPL25 SGTC_1311 1190-0148 100 µM 0.734556308948744 0.241728548189392 no 841 0.231304877493967 1201 1961333 SGTC_3259 9138485 49.47 µM 0.733739561327745 0.2419712048114 no 842 0.231553741104208 1250 17646153 SGTC_3257 9139206 32.98 µM 0.733355649677291 0.242085311020389 no 843 0.231670770818207 1112 4910041 SGTC_207 4185-0010 4.486 µM 0.732930000779194 0.242211856473569 no 844 0.231800562028646 1201 3761753 SGTC_2415 st077333 57.7 µM 0.732530561067303 0.242330642539142 no 845 0.231922398223368 1184 2766255 SGTC_2781 5567276 71.43 µM 0.731439703846147 0.242655204291613 no 846 0.232255310637339 1108 2853274 SGTC_2932 9016711 44.54 µM 0.731377038326739 0.242673856252071 no 847 0.232274443238188 1145 7117328 SGTC_2291 7917025 104.35 µM 0.731211716110506 0.242723066996418 no 848 0.232324922476462 1113 2964612 SGTC_1098 clofazimine 15.1 µM 0.729700232101608 0.243173234222197 no 849 0.232786719610983 1148 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2119 5528445 120.635 µM 0.729635362801233 0.243192564426431 no 850 0.232806550254656 1130 791935 SGTC_2185 6113692 200 µM 0.728589672799481 0.24350428098794 no 851 0.233126348767113 1134 874150 SGTC_1737 st035557 69.7 µM 0.726900255811446 0.244008346011563 no 852 0.233643530235304 1013 5716916 SGTC_514 4466-0038 2.65 nM 0.726856323013223 0.244021461580942 no 853 0.233656987870212 1119 5722064 SGTC_956 1185-0240 191 µM 0.726749898139055 0.24405323492863 no 854 0.233689590058619 1137 1416193 SGTC_1780 st038448 24.544 µM 0.722307694051511 0.245381451652138 no 855 0.235052661760683 1146 728868 YDL195W SEC31 SGTC_624 k048-0052 28 µM 0.720118335461548 0.246037495097439 no 856 0.23572606961023 1111 6835531 SGTC_1640 st009078 66.4 µM 0.719217607306757 0.246307672112186 no 857 0.236003426185325 1135 690618 SGTC_2284 7945075 39.21 µM 0.718932586855798 0.246393198251428 no 858 0.236091228503482 1234 1245402 SGTC_309 k408-0051 1.48 µM 0.718858733156724 0.246415362140657 no 859 0.236113982529065 1158 3640463 SGTC_949 1165-0505 146 µM 0.718788057779162 0.246436573199079 no 860 0.236135758457849 1181 6244267 SGTC_218 alverine citrate 93.75 µM 0.717035610987401 0.246962829411034 no 861 0.236676061926627 1130 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1174 0739-0097 51.1 µM 0.716615353525713 0.247089121212321 no 862 0.236805734110694 1153 728447 SGTC_288 1315-0019 35.1 µM 0.715271577966416 0.247493171675856 no 863 0.237220623693631 1179 6811474 SGTC_2780 5215298 71.43 µM 0.711165363944635 0.248730024919533 no 864 0.238490884538906 1186 2834131 SGTC_1678 st019265 80.2 µM 0.710155749749969 0.24903463922268 no 865 0.238803778948356 1188 5367020 SGTC_1608 st001473 40.5 µM 0.709807612568161 0.249139722937669 no 866 0.238911723865783 1135 7292267 SGTC_2021 4019055 173 µM 0.708925214564865 0.24940617660528 no 867 0.239185443486783 1201 44827708 YER133W GLC7 SGTC_2850 9015429 58.44 µM 0.70875972067883 0.249456166895224 no 868 0.239236798722678 1175 6457570 SGTC_3163 9099914 49.47 µM 0.708687039971962 0.249478123042201 no 869 0.239259354540315 1172 16268368 SGTC_318 1488-0629 67.2 µM 0.707404042580317 0.249865873300355 no 870 0.23965771270821 1180 3662576 SGTC_2452 5863136 48.41 µM 0.707290581721762 0.249900179077263 no 871 0.2396929586105 1160 2184096 SGTC_2654 protoveratrine a 100 µM 0.704996921523193 0.250594220922647 no 872 0.24040607597857 1173 5702278 A heart drug and vasodilator. SGTC_2407 paclitaxel 400 µM 0.704560092827922 0.250726517187996 no 873 0.240542020409656 1190 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3055 9094636 49.47 µM 0.703370219009644 0.251087065314402 no 874 0.240912530438245 1218 25236176 SGTC_744 1594-0068 283 µM 0.70080858468579 0.251864205646683 no 875 0.241711239942569 1216 668392 SGTC_2258 7960471 200 µM 0.699728599907028 0.25219222802161 no 876 0.24204840601909 1153 2974708 SGTC_1330 1469-0054 61.8 µM 0.699021133642704 0.252407227903538 no 877 0.242269411786808 1210 7102664 SGTC_963 1269-2853 151 µM 0.698593614318149 0.252537198373763 no 878 0.242403017774871 1182 3668223 SGTC_1880 MG-132 525 µM 0.698397188233136 0.252596925834993 no 879 0.242464417156015 1135 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_139 0099-0334 718.624 µM 0.696239847926938 0.253253399658996 no 880 0.24313931828973 1249 97690 SGTC_177 1327-0068 8.361 µM 0.693694765073516 0.254029014549054 no 881 0.243936824827558 1201 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2357 9067248 200 µM 0.690827404525686 0.254904334331634 no 882 0.244837005778287 1192 9150235 SGTC_1329 1447-1697 50.6 µM 0.689072315476963 0.255440888481666 no 883 0.245388880390956 1191 2840515 SGTC_411 enrofloxacin 100 µM 0.688569237878246 0.255594794772316 no 884 0.245547192563614 1256 71188 A bacterial gyrase inhibitor. SGTC_387 norethindrone acetate 66.7 µM 0.686943208915925 0.256092576106176 no 885 0.246059258397859 1198 541197 SGTC_578 3460-0051 92 µM 0.68624375204595 0.256306858453034 no 886 0.246279706055445 1270 2876744 SGTC_93 0109-0045 59.227 µM 0.685779375829591 0.256449174189712 no 887 0.246426121861993 1283 88733 SGTC_1212 0520-0165 585 µM 0.683043259100468 0.257288537421409 no 888 0.247289753918199 1333 5403258 SGTC_3221 9128209 49.47 µM 0.681919731089724 0.257633617139417 no 889 0.247644854105042 1235 16460723 SGTC_1973 st070275 50.2 µM 0.681684540213979 0.257705883930759 no 890 0.24771922255641 1161 17118334 SGTC_2356 9061756 188.97 µM 0.681528987897909 0.257753686067586 no 891 0.247768415475324 1190 20104043 SGTC_542 3381-0244 89.3 µM 0.68110442414778 0.257884180412638 no 892 0.247902708935576 1234 1112843 SGTC_2279 7948423 32.93 µM 0.679938714009026 0.258242650456994 no 893 0.248271633567947 1225 1247112 SGTC_1872 amphotericin b 148 nM 0.679612561617763 0.258342992504955 no 894 0.248374906853829 1226 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1265 0819-1001 68.8 µM 0.678387316228775 0.258720124428067 no 895 0.24876307452754 1228 3106768 SGTC_573 3702-0553 84.7 µM 0.677800006981589 0.258900999865459 no 896 0.248949253319616 1210 1222756 SGTC_2938 9059746 27.26 µM 0.677432158366038 0.259014320645804 no 897 0.249065900189971 1187 6471769 SGTC_2023 5144124 124 µM 0.676688456648129 0.259243506430044 no 898 0.249301820991501 1208 2830192 SGTC_1839 st053978 48 µM 0.674034083407109 0.260062355634802 no 899 0.250144822479392 1273 3788398 SGTC_2555 cholic acid 100 µM 0.673899086230973 0.260104036602065 no 900 0.250187736553862 1236 6708657 Influences liver metabolism. SGTC_1722 st034304 3.6505 µM 0.671981984748753 0.260696321547656 no 901 0.250797582623543 1252 4036148 YLR033W RSC58 SGTC_2236 dapsone 200 µM 0.666653336911039 0.262346235531346 no 902 0.252496795729692 1257 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1856 st057054 55.7 µM 0.665447969299561 0.262720194863157 no 903 0.252882006087129 1325 1266018 SGTC_1415 3966-0071 78.1 µM 0.664889150720414 0.262893658029651 no 904 0.253060697743086 1241 2893185 SGTC_2470 5664817 21.68 µM 0.663568288200979 0.263303900315755 no 905 0.253483329714459 1273 2859561 SGTC_1628 st004252 77.7 µM 0.662132827457356 0.263750105685858 no 906 0.253943049499084 1241 692968 SGTC_2997 9067075 71.4286 µM 0.661920997569036 0.263815984522824 no 907 0.254010927038337 1243 27209819 SGTC_1438 4092-1045 4 µM 0.661916731844064 0.263817311244265 no 908 0.254012294020246 1235 1351342 SGTC_1487 3970-0795 2.82 µM 0.660608836388527 0.264224251923568 no 909 0.254431600368305 1292 3765103 SGTC_62 0180-0423 3.232 µM 0.660116459538251 0.264377533626973 no 910 0.254589548457056 1225 30102 YGL099W LSG1 SGTC_2962 9082311 13.18 µM 0.659219364523157 0.264656924349877 no 911 0.254877456850907 1237 16459453 SGTC_1441 4106-0040 13 µM 0.658899864723989 0.264756465425295 no 912 0.25498003637287 1245 2904180 SGTC_2211 7117706 200 µM 0.65774811727227 0.26511545356366 no 913 0.255349998924313 1211 822771 SGTC_2766 oltipraz 83.91 µM 0.657464817498741 0.265203793134135 no 914 0.255441043018381 1258 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2564 betulinic acid 100 µM 0.657362381936459 0.265235738644357 no 915 0.255473966926559 1295 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2014 4013930 200 µM 0.655281344301183 0.265885152888466 no 916 0.256143314911324 1238 64556 SGTC_3267 9137951 49.47 µM 0.654371696493382 0.266169272909419 no 917 0.25643618234487 1257 16643986 SGTC_2 0422-0095 29 µM 0.652936615935973 0.266617819284966 no 918 0.256898571009969 1155 6790840 SGTC_485 niflumic acid 177 µM 0.651978660543157 0.266917448783271 no 919 0.257207469333922 1283 4488 A COX2 inhibitor. SGTC_1667 st014849 34.6 µM 0.651847712426511 0.266958419975243 no 920 0.257249709317628 1288 5348460 SGTC_353 1988-1175 58.3 µM 0.649526145017048 0.267685321530574 no 921 0.257999176433457 1194 2788357 SGTC_1155 4088-0394 48.2 µM 0.648545980169605 0.267992518283769 no 922 0.258315940842219 1236 2326248 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.648509432261184 0.268003976318209 no 923 0.258327756095331 1242 6708760 SGTC_1819 st053448 58.6 µM 0.648492993258702 0.26800913014517 no 924 0.258333070607729 1235 2857616 SGTC_2474 5321570 43.32 µM 0.647103928998923 0.26844479883297 no 925 0.258782341308018 1294 2841384 SGTC_290 2043-6722 48.1 µM 0.645745783845789 0.268871114015138 no 926 0.259222002347139 1273 773758 YLR208W SEC13 SGTC_2935 9038016 29.96 µM 0.645385819461253 0.268984162058569 no 927 0.259338595314308 1254 6463195 SGTC_78 0336-0123 156.75 µM 0.64483158477451 0.269158267990969 no 928 0.259518165665515 1192 6765896 SGTC_1806 st050005 60.3 µM 0.643937429479278 0.269439274891549 no 929 0.259808004556188 1242 5194765 SGTC_3134 9127454 49.47 µM 0.643322849923666 0.269632504542571 no 930 0.260007316262735 1353 24262820 SGTC_1851 st056236 18.9 µM 0.642753987346729 0.269811422189331 no 931 0.260191871931024 1297 5393171 SGTC_2969 9091408 28.7 µM 0.638548709515695 0.271135899920474 no 932 0.261558278457009 1247 4286311 SGTC_1159 4092-0538 61.2 µM 0.635809141598094 0.272000484032762 no 933 0.2624504141847 1324 717301 SGTC_1122 capsaicin 818.572 nM 0.634810008890684 0.272316142588759 no 934 0.262776167347052 1360 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_444 curcumin 90.4 µM 0.62963615793929 0.273953636257984 no 935 0.264466330492032 1269 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_703 3875-0075 71.8 µM 0.628994551855249 0.274157039533686 no 936 0.264676311499835 1350 2850814 SGTC_3027 9089541 49.47 µM 0.628885697326429 0.274191556219966 no 937 0.264711945171325 1291 9943819 SGTC_1887 st057648 70.8 µM 0.628298499555969 0.274377787790742 no 938 0.264904207190594 1297 688672 SGTC_557 1315-0110 16.2 µM 0.626621675235034 0.274909941242542 no 939 0.265453628364803 1291 6833801 SGTC_2716 st080858 38.6235 µM 0.625197237368982 0.275362397044726 no 940 0.265920807432388 1272 5296050 SGTC_2096 5468907 200 µM 0.625100398681491 0.275393170003558 no 941 0.265952583153871 1309 759785 SGTC_541 4513-1321 94 µM 0.62326791012258 0.275975808668692 no 942 0.266554240831884 1246 747515 SGTC_3066 9117245 49.47 µM 0.622325129628768 0.276275800847178 no 943 0.266864050201856 1376 17176980 SGTC_1105 epirubicin 18.1 µM 0.622256160021842 0.276297753213168 no 944 0.266886721609867 1239 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1501 4491-0275 38.4 µM 0.622192786726767 0.276317925081059 no 945 0.266907554278843 1286 5104718 SGTC_2369 9071472 200 µM 0.621420149729662 0.276563915326462 no 946 0.267161608863754 1361 17296037 SGTC_1475 4092-1048 11.7 µM 0.620941028829245 0.276716510553031 no 947 0.267319212266141 1302 2881759 SGTC_2720 fluspirilene 36.88 µM 0.620866772236259 0.276740164228751 no 948 0.267343642640477 1297 3396 An atypical antipsychotic. SGTC_3293 9120939 62.045 µM 0.617674357405039 0.277758010901062 no 949 0.26839500921718 1337 934087 SGTC_1687 st020778 55.3625 µM 0.61738184565534 0.277851364600338 no 950 0.268491446783929 1322 4259299 SGTC_1362 1611-0397 101 µM 0.610933509995758 0.279913201078893 no 951 0.270621799629863 1315 27816 SGTC_2067 5224629 34.075 µM 0.610602615665866 0.280019203387282 no 952 0.270731345320686 1306 2835000 SGTC_1986 st071812 45 µM 0.610556115829459 0.280034101212756 no 953 0.270746741304441 1321 11838594 SGTC_538 2922-0838 53.3 µM 0.610151794749511 0.280163655600062 no 954 0.270880629461391 1373 777039 SGTC_145 3737-0113 38.366 µM 0.610143250463657 0.28016639371206 no 955 0.270883459199611 1329 6849351 SGTC_381 3461-2219 42.7 µM 0.609948606701226 0.280228772995387 no 956 0.270947926264841 1322 2883159 SGTC_1728 st035614 33.7865 µM 0.609462787573954 0.280384497283716 no 957 0.271108865573744 1381 15945546 SGTC_1365 1672-3266 55.4 µM 0.609421642342482 0.280397687885775 no 958 0.271122498113974 1321 6415873 SGTC_2206 7254556 146.969 µM 0.609374034238848 0.28041295077176 no 959 0.271138272407062 1313 4398905 SGTC_1451 4152-0210 104 µM 0.60767697420637 0.280957281079136 no 960 0.271700868744992 1388 659563 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.605113423821881 0.281780504354034 no 961 0.272551817722258 1295 390807 SGTC_1301 naphtanilide LB 4.81 µM 0.604979511911614 0.281823538912481 no 962 0.272596304990881 1403 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1034 k072-0165 12.7 µM 0.603094860437827 0.282429535061776 no 963 0.273222792664969 1351 5835461 SGTC_1669 st015249 58.4 µM 0.602509100435382 0.282618009566115 no 964 0.27341765366761 1397 722793 SGTC_3201 9113999 49.47 µM 0.601157336853949 0.283053184447195 no 965 0.273867598590733 1392 16649224 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.599629912166036 0.283545296806772 no 966 0.274376453811812 1363 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2663 amphotericin b 100 µM 0.598776716965165 0.283820361311112 no 967 0.274660895281793 1324 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2799 7812892 81.82 µM 0.59855845810384 0.283890747042223 no 968 0.274733682605923 1364 20205235 SGTC_3006 9075424 71.4286 µM 0.597244976435388 0.284314504651367 no 969 0.275171917406721 1301 7465181 SGTC_2522 biochanin a 4.94 µM 0.594369944590176 0.285243105802849 no 970 0.276132353081503 1329 5280373 A possible chelator. SGTC_670 4204-0025 119 µM 0.594038706096543 0.285350184672043 no 971 0.276243112529465 1382 719039 SGTC_2679 rapamycin 1 nM 0.593235047260733 0.285610061559219 no 972 0.276511930355689 1335 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_863 0466-0191 129 µM 0.592479310562155 0.285854544710641 no 973 0.276764835543633 1348 765160 YPR165W RHO1 SGTC_2404 5161160 200 µM 0.592428165130991 0.285871094009766 no 974 0.276781955313308 1331 2831543 SGTC_899 1083-0020 478 µM 0.592068018596444 0.285987640730915 no 975 0.276902520858816 1405 767123 SGTC_2735 sertaconazole 140 nM 0.592024422508772 0.286001750356826 no 976 0.27691711717991 1420 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_535 2293-4129 48.2 µM 0.59164803863893 0.286123578612075 no 977 0.277043149193915 1388 396118 YIL048W NEO1 SGTC_3024 9090631 49.47 µM 0.590794290916805 0.286400011756882 no 978 0.277329130360342 1312 25236383 SGTC_1898 st060199 18.6 µM 0.589219107113398 0.286910369566578 no 979 0.277857150640303 1348 688866 SGTC_2731 amoxapine 43.43 µM 0.589094138697224 0.286950877637072 no 980 0.277899062537865 1404 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3059 1327-0034 3 µM 0.588645823819552 0.287096219610454 no 981 0.278049443733005 1307 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1864 st057645 30.4 µM 0.588305009723184 0.287206733557442 no 982 0.278163791793849 1367 688666 SGTC_2622 2-methoxyxanthone 59.94 µM 0.588248293344357 0.287225126625472 no 983 0.278182823185245 1417 71034 A hepatoprotective. SGTC_894 0960-0238 55.9 µM 0.586203301532568 0.287888687684863 no 984 0.278869451657403 1347 6741907 YDL195W SEC31 SGTC_1809 st050081 57.6 µM 0.585764444420242 0.288031182786212 no 985 0.279016910158467 1410 5036894 SGTC_746 1095-0025 46.6 µM 0.585106885280902 0.288244751824981 no 986 0.27923792474503 1370 6749286 SGTC_2245 6637752 200 µM 0.585040548912859 0.288266301401801 no 987 0.279260226026098 1360 681890 SGTC_1932 st074806 40.9 µM 0.583203126386822 0.288863495634935 no 988 0.279878283393715 1454 17251235 SGTC_1529 apigenin 74 µM 0.581449517766378 0.289433991379222 no 989 0.280468766143326 1464 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3173 9105693 49.47 µM 0.581326622182096 0.289473992434331 no 990 0.28051017068218 1399 17096658 SGTC_1775 st081588 35.1725 µM 0.580298948530941 0.289808589613947 no 991 0.280856518189508 1364 1426443 YGL099W LSG1 SGTC_2867 9039098 71.43 µM 0.579441098394405 0.290088033332592 no 992 0.281145789848347 1338 6463460 SGTC_1227 3909-8010 46.6 µM 0.57940458769401 0.290099929453537 no 993 0.281158104643905 1380 15982272 SGTC_428 3448-4153 16.5 µM 0.577802187573994 0.290622257508871 no 994 0.28169883909754 1322 3834874 SGTC_1454 4239-0054 42.6 µM 0.574501983278926 0.29169939599831 no 995 0.282814079428349 1461 1340767 SGTC_274 sirtinol 40.1 µM 0.574383179903146 0.291738206358005 no 996 0.282854266251067 1336 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1546 5-methoxyflavanone 78.7 µM 0.57151705582962 0.292675232302169 no 997 0.283824601100063 1427 147795 SGTC_1689 st020265 53.493 µM 0.570359136948096 0.29305418840105 no 998 0.284217069443131 1446 5758320 YPR016C TIF6 SGTC_3030 9087619 49.47 µM 0.569823808355907 0.293229464137566 no 999 0.284398602916778 1338 25236973 SGTC_1755 st041960 45.185 µM 0.567425133625748 0.294015427363881 no 1000 0.285212688970992 1391 2257073 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.567203205121314 0.294088194899857 no 1001 0.285288065358272 1369 279621 SGTC_2234 tolnaftate 200 µM 0.567125692028821 0.294113612418927 no 1002 0.285314394347081 1374 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_787 4152-0075 138 µM 0.562658761206005 0.295580087132652 no 1003 0.286833635308783 1431 9566539 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.561613268012163 0.295923803047914 no 1004 0.28718976928405 1390 521171 SGTC_1631 benzylvanillin 81.9 µM 0.561144097934383 0.296078106848334 no 1005 0.287349654121408 1432 75506 SGTC_3255 9139072 49.47 µM 0.560684968960705 0.296229144001342 no 1006 0.287506157885728 1396 17646060 SGTC_174 3553-0389 74.3 µM 0.560413793076886 0.296318367849645 no 1007 0.287598612816285 1411 738071 SGTC_316 k060-0003 58.6 µM 0.560081141735184 0.296427835533147 no 1008 0.287712046430704 1413 6152314 SGTC_289 k017-0060 526 µM 0.559729261386041 0.296543651197981 no 1009 0.287832060111929 1390 5512909 SGTC_129 0088-0017 176.636 µM 0.558627945393459 0.296906265268192 no 1010 0.288207831961975 1367 182446 SGTC_48 0382-0018 55 µM 0.557398591714401 0.297311275889364 no 1011 0.288627563732467 1498 762596 SGTC_835 0312-0010 67.2 µM 0.556673501475218 0.297550275188096 no 1012 0.288875262407655 1367 1626196 SGTC_1043 0916-0009 19.3 µM 0.555797366004494 0.297839177942987 no 1013 0.289174693178506 1487 3101130 SGTC_3161 9100388 49.47 µM 0.552782436467555 0.298834317006419 no 1014 0.290206198297498 1457 25236368 SGTC_2734 clemastine 41.6 µM 0.552623967662587 0.298886664640462 no 1015 0.290260463262728 1404 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1206 3978-0017 132 µM 0.550878458317094 0.299463541171899 no 1016 0.290858497711273 1474 3873677 SGTC_509 pifithrin 175 µM 0.548367889396606 0.300294147523032 no 1017 0.291719660137409 1501 4817 A p53 inhibitor. SGTC_2401 5128683 200 µM 0.547560041879648 0.300561640194659 no 1018 0.291997016314485 1335 708373 SGTC_3047 9092122 49.47 µM 0.546261529976098 0.300991825862676 no 1019 0.292443088108364 1371 17173831 SGTC_2019 4016004 108 µM 0.544766500212396 0.301487459654882 no 1020 0.292957060743757 1373 45595336 SGTC_3335 9143315 29.6265 µM 0.544254233752509 0.301657371195644 no 1021 0.293133267949578 1417 4899691 SGTC_34 0469-0683 81.75 µM 0.544155567158646 0.301690102455024 no 1022 0.293167212502855 1465 3690923 SGTC_2828 7998861 71.43 µM 0.544050995526366 0.30172479437122 no 1023 0.293203190572957 1415 2988188 SGTC_20 0481-0013 4.944 µM 0.543867064114481 0.301785818456112 no 1024 0.293266477493378 1387 182045 SGTC_855 0428-0020 25 µM 0.543128124927521 0.302031036867631 no 1025 0.293520794681405 1414 6812414 SGTC_2909 7941780 10.49 µM 0.542555423641598 0.30222115043647 no 1026 0.293717968787551 1436 1243215 SGTC_2256 7954252 200 µM 0.54247582497389 0.30224757821187 no 1027 0.293745378494549 1369 2972920 SGTC_122 0236-0016 402.397 µM 0.541897747100552 0.302439538561735 no 1028 0.293944474428764 1443 6808838 SGTC_2992 9074591 71.4286 µM 0.536923163402223 0.304093685787731 no 1029 0.295660345053083 1429 17741321 SGTC_1779 st039427 55 µM 0.534634973461911 0.304855905474361 no 1030 0.296451147409516 1588 1124498 SGTC_2755 lomerizine 42.69 µM 0.533925590296147 0.305092380616799 no 1031 0.296696508153943 1410 3949 A calcium channel blocker. SGTC_2707 st078556 66.6 µM 0.533525550351323 0.305225771111908 no 1032 0.296834914566277 1461 17250899 SGTC_2673 kobusone 100 µM 0.533449206372335 0.305251230413173 no 1033 0.296861331526672 1494 6710676 An epoxy ketone and protein crosslinker. SGTC_3142 9086498 49.47 µM 0.532813161820544 0.305463376092352 no 1034 0.297081460944418 1380 25236367 SGTC_357 1325-0123 420 µM 0.532664304564761 0.305513035234178 no 1035 0.297132989906446 1450 1098503 SGTC_1703 st026983 48.3 µM 0.532369712853033 0.305611322291525 no 1036 0.297234978874548 1501 1104023 SGTC_524 r073-0010 27.8 µM 0.528465261788608 0.306915317461618 no 1037 0.298588225828526 1383 2772106 SGTC_1039 k821-0043 94 µM 0.527097091506811 0.307372834028796 no 1038 0.299063083201132 1522 15992768 SGTC_1749 st037932 54.2 µM 0.526561029891213 0.307552175013456 no 1039 0.299249230099371 1440 594497 SGTC_601 0986-0029 62.9 µM 0.526331641938676 0.307628931483949 no 1040 0.299328900910062 1441 24747981 SGTC_372 0155-0182 15.9 µM 0.525899732675739 0.307773477320481 no 1041 0.299478937339817 1454 771486 SGTC_640 3381-0960 37.1 µM 0.524624778712585 0.308200336496466 no 1042 0.299922028952248 1535 1745025 SGTC_2561 acetosyringone 100 µM 0.524233797737525 0.308331290357343 no 1043 0.300057968097562 1411 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2701 st077767 14.721 µM 0.524217025365819 0.308336908585251 no 1044 0.30006380026274 1417 5721188 SGTC_3247 9135149 49.47 µM 0.523271718500555 0.308653629802129 no 1045 0.30039258950884 1431 8934436 YOR116C RPO31 SGTC_643 k048-0106 28.4 µM 0.523035994545639 0.308732630344468 no 1046 0.300474602521379 1504 6763920 SGTC_1961 st076550 68.7 µM 0.522722209116156 0.308837806149072 no 1047 0.300583790349497 1442 1579337 SGTC_773 4358-1457 44.6 µM 0.522587540142545 0.308882949821407 no 1048 0.300630656567955 1565 1186886 SGTC_2189 6047310 154.431 µM 0.52102084243486 0.309408349560148 no 1049 0.30117612607117 1404 711535 SGTC_1333 1482-0047 286 µM 0.519635345740246 0.30987330755216 no 1050 0.301658878872581 1445 3811116 SGTC_3240 9133527 49.47 µM 0.519155412642494 0.310034439005436 no 1051 0.301826184525131 1435 17617455 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.518771128633693 0.310163483797585 no 1052 0.301960176768052 1420 2346 DNA damaging agent; causes G2/M arrest. SGTC_3223 9129970 49.47 µM 0.518686058506524 0.310192053999653 no 1053 0.301989842653027 1509 17248386 SGTC_1246 0422-0085 105 µM 0.518555214944073 0.310235999123286 no 1054 0.302035473329211 1488 264295 SGTC_4 0960-0234 25.671 µM 0.517929417016412 0.310446217103659 no 1055 0.302253758302392 1448 6821112 SGTC_222 nsc-310342 10.666 µM 0.517792873085743 0.310492093160598 no 1056 0.302301395684084 1485 432556 SGTC_2618 avocadyne 43.43 µM 0.517584573453311 0.310562083390889 no 1057 0.302374073648964 1459 3015189 SGTC_400 oxethazaine 37.5 µM 0.516930291842925 0.310781971486043 no 1058 0.302602410437924 1448 4621 A local anesthetic. SGTC_2636 apigenin dimethyl ether 100 µM 0.51620908244618 0.311024430701685 no 1059 0.302854193751445 1468 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_951 1171-0579 82.7 µM 0.516158149814923 0.311041556551273 no 1060 0.30287197852206 1381 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1588 farnesol 29.9 µM 0.515835997891165 0.311149888046906 no 1061 0.302984479084455 1447 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1465 k213-0056 144 µM 0.515170794782454 0.311373630694349 no 1062 0.30321683771469 1433 24048857 YMR208W ERG12 SGTC_1783 st039459 87.517 µM 0.512828818933547 0.312161914025309 no 1063 0.304035534369055 1604 729761 SGTC_453 enantio-paf c16 10 µM 0.512733351995696 0.312194065430023 no 1064 0.30406892813495 1447 13871343 A lipid and platelet activating factor SGTC_959 1222-0044 107 µM 0.511151347910897 0.312727061676201 no 1065 0.304622541549436 1503 6083612 SGTC_1901 st060216 58.6 µM 0.510254947395406 0.31302924380169 no 1066 0.304936430702082 1455 688792 SGTC_980 1473-0395 201 µM 0.510041596874452 0.313101184091579 no 1067 0.305011160004785 1419 768876 SGTC_1481 3346-2004 36 µM 0.509656368186949 0.313231098507188 no 1068 0.305146112876784 1463 2770522 SGTC_3237 9133362 49.47 µM 0.5093701361155 0.313327642345173 no 1069 0.305246402527627 1511 43845137 SGTC_1299 1079-1439 3.74 µM 0.509002796384679 0.313451561906997 no 1070 0.305375132007968 1422 323161 SGTC_3035 9091303 49.47 µM 0.508398642162945 0.313655415025265 no 1071 0.305586902423861 1475 25237002 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.508186637453436 0.31372696293729 no 1072 0.305661230536789 1478 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1186 1319-0216 26 µM 0.508005098636988 0.313788234707408 no 1073 0.305724883778616 1582 4565136 SGTC_1392 3455-1037 33.9 µM 0.507381782459246 0.31399865130768 no 1074 0.305943482786767 1507 981132 SGTC_1353 1498-1206 8.11 µM 0.506770408767192 0.314205095175529 no 1075 0.306157960697191 1480 6756808 SGTC_189 3970-0742 2.116 µM 0.50654642140546 0.314280744024707 no 1076 0.306236555039802 1498 2891807 SGTC_1927 st060202 13.8 µM 0.505578166726781 0.314607849303846 no 1077 0.306576405964768 1485 688887 SGTC_866 0495-0101 262 µM 0.505496802244664 0.314635343283389 no 1078 0.30660497193715 1414 635694 SGTC_3313 9133968 57.047 µM 0.504357982374444 0.31502027121968 no 1079 0.307004919479514 1445 1494643 SGTC_2450 5739737 12.93 µM 0.501998300766486 0.315818497073889 no 1080 0.307834358131847 1470 2262825 SGTC_935 2996-0153 430 µM 0.501241097521227 0.316074823850131 no 1081 0.308100726979297 1499 23738523 SGTC_3190 9110366 49.47 µM 0.500178707329825 0.316434610909951 no 1082 0.308474624882685 1548 17123768 SGTC_307 1501-1223 22.3 µM 0.49772177791825 0.317267335316283 no 1083 0.309340078037517 1472 2830329 SGTC_481 bay k-8644 50 µM 0.497613849384914 0.317303936676748 no 1084 0.309378120163332 1440 2303 A calcium channel antagonist. SGTC_760 0568-0725 82.9 µM 0.496337535204606 0.317736903284422 no 1085 0.309828144045449 1587 3916171 SGTC_2770 toltrazuril 17.5 µM 0.495049378845999 0.318174139994598 no 1086 0.310282632589961 1503 68591 Kills coccidiodes. SGTC_2266 7929956 200 µM 0.494212313891864 0.318458399447042 no 1087 0.310578122082697 1470 2967153 SGTC_266 formosanin C 406 nM 0.493957295148493 0.318545022687588 no 1088 0.310668169700183 1496 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2375 9072683 200 µM 0.493566238514918 0.318677873730372 no 1089 0.310806274596297 1624 16798029 SGTC_2457 5731572 11.68 µM 0.491208446608339 0.319479363977853 no 1090 0.311639512725746 1623 2865357 SGTC_2068 5226020 147 µM 0.491182348801673 0.319488240201936 no 1091 0.311648741038969 1458 1810509 SGTC_3342 9147791 14.508 µM 0.490353531343621 0.319770186230364 no 1092 0.311941876490791 1456 1838168 SGTC_2085 5307070 144.047 µM 0.490129221464865 0.319846509586955 no 1093 0.31202123071215 1436 2840351 SGTC_1114 scopoletin 1.73284 µM 0.489846887739395 0.319942586896518 no 1094 0.312121124461272 1581 5280460 A coumarin with genotoxic properties. SGTC_2835 9006588 71.43 µM 0.489700801504271 0.319992304341079 no 1095 0.312172817305145 1483 2345538 SGTC_3158 9100007 49.47 µM 0.488420848560082 0.320428048170794 no 1096 0.312625888720776 1473 19297233 SGTC_665 3914-0008 307 µM 0.487397956805275 0.320776456854441 no 1097 0.31298817060329 1448 1069549 SGTC_832 4083-0019 164 µM 0.485638128458797 0.32137624405314 no 1098 0.313611879044957 1628 1990758 SGTC_2516 gossypol 71.55 µM 0.484700428170965 0.321696022845853 no 1099 0.313944431364542 1617 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1874 staurosporine 7.6 µM 0.481493156145939 0.322790779009073 no 1100 0.315083021327566 1571 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2050 5263056 171 µM 0.48056182273721 0.323108964759932 no 1101 0.315413977199253 1567 763468 YGL055W OLE1 SGTC_1185 1319-0113 81.3 µM 0.479899297031717 0.323335392432445 no 1102 0.315649500562435 1546 4672763 SGTC_2252 omeprazole 400 µM 0.478666248018498 0.323756978853644 no 1103 0.316088040411499 1569 4594 A proton pump inhibitor. SGTC_1267 0828-0272 9.49 µM 0.47835252676205 0.323864278048346 no 1104 0.316199658232106 1619 745334 SGTC_73 0327-0325 16.231 µM 0.477962892482525 0.323997561456266 no 1105 0.316338308210834 1566 53298 SGTC_2820 7989630 71.43 µM 0.477825899169747 0.324044428546874 no 1106 0.316387062932732 1501 2984098 SGTC_3354 9151612 71.43 µM 0.477725084244054 0.324078920349525 no 1107 0.316422944121674 1596 27261949 SGTC_1857 st056007 79.3 µM 0.475390578522027 0.324878046467807 no 1108 0.317254304254192 1514 619834 SGTC_812 4251-0442 148 µM 0.473844942062981 0.325407578285561 no 1109 0.317805241787247 1525 5723007 SGTC_392 N-ethylmaleimide 8.33 µM 0.470792368188867 0.326454418945906 no 1110 0.318894507528156 1502 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_555 4296-0685 37 µM 0.468734921645364 0.327160766113239 no 1111 0.319629561067514 1557 2908540 YHR072W ERG7 SGTC_3039 9090270 49.47 µM 0.468349747703849 0.327293070069627 no 1112 0.319767249105339 1586 17173750 SGTC_1360 1598-0022 39.8 µM 0.468304639651371 0.327308565719826 no 1113 0.319783375495401 1608 761525 SGTC_1688 st021091 57.6 µM 0.466601816097136 0.32789374210934 no 1114 0.320392393711503 1629 3656366 SGTC_263 alizarin 107.927 µM 0.466547048752874 0.327912569967269 no 1115 0.320411989403086 1565 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2930 9013230 14.89 µM 0.465455500757912 0.328287912323158 no 1116 0.32080264837331 1625 2995857 SGTC_1784 st039334 36.3 µM 0.463742426954639 0.328877323579426 no 1117 0.321416148121635 1621 3496984 SGTC_1630 st005209 31.3 µM 0.459801635196086 0.330234832492591 no 1118 0.322829304700208 1576 3367314 SGTC_1345 1488-0192 31.4 µM 0.459759439811632 0.330249379936587 no 1119 0.322844449742506 1613 658348 SGTC_612 0302-0167 22.4 µM 0.457900824786921 0.330890417549806 no 1120 0.323511847153445 1627 235821 SGTC_1554 st069299 38.7 µM 0.457409292553617 0.331060030394945 no 1121 0.323688443199986 1544 24207999 SGTC_1560 lithocholic acid 53.1 µM 0.454705183446725 0.331993755639363 no 1122 0.324660675638216 1567 9903 A bile acid which acts as a detergent. SGTC_2814 7977482 42.97 µM 0.45456527307013 0.332042094966265 no 1123 0.324711011456721 1671 6456762 SGTC_914 3820-6779 408 µM 0.454337143937224 0.332120920052109 no 1124 0.324793092767895 1488 2893481 SGTC_1515 3460-0031 42.1 µM 0.45246379697417 0.332768495268845 no 1125 0.325467448178366 1516 2876596 SGTC_2847 9005661 71.43 µM 0.451304477957775 0.33316949679092 no 1126 0.325885058954965 1520 2991449 SGTC_833 3852-0053 558 µM 0.450522636245715 0.3334400389287 no 1127 0.326166817994046 1614 3123681 SGTC_2628 lathosterol 100 µM 0.447490952326174 0.334489916588364 no 1128 0.327260309534131 1577 6710616 SGTC_718 1130-0073 349 µM 0.4473734880189 0.334530620816453 no 1129 0.327302707406884 1626 6740020 SGTC_1540 guanosine 70.6 µM 0.446977979934246 0.334667688246921 no 1130 0.327445479502456 1574 6802 Guanosine is a purine nucleoside SGTC_2052 5265182 7.135 µM 0.446421168902982 0.334860694231809 no 1131 0.327646522162042 1652 1239884 SGTC_2558 carylophyllene oxide 100 µM 0.445919161616583 0.335034741135828 no 1132 0.327827820179857 1610 6708694 An oxygenated terpenoid and antifungal agent. SGTC_397 arbidol 50 µM 0.445667066747434 0.335122156283994 no 1133 0.327918878592329 1638 131410 A RNA synthesis inhibitor. SGTC_2121 5257820 149.641 µM 0.44551989055828 0.335173194487961 no 1134 0.327972044381389 1654 791256 SGTC_2083 5306046 65.942 µM 0.44511852520357 0.335312396642909 no 1135 0.328117050941634 1535 539837 SGTC_1603 st002045 67.8 µM 0.444139288011843 0.335652112070142 no 1136 0.328470941566195 1603 5887985 SGTC_2108 5365811 200 µM 0.443770634579126 0.335780039569955 no 1137 0.328604210674463 1625 780283 SGTC_2683 piperine 63.03 µM 0.44154280786047 0.33655352877383 no 1138 0.329410038930311 1556 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3230 9131665 49.47 µM 0.440280942435554 0.336991948776561 no 1139 0.329866820894029 1565 15943720 SGTC_3022 9087993 49.47 µM 0.437770316254128 0.337864894131941 no 1140 0.33077639545871 1621 17173644 SGTC_2157 5649910 96.377 µM 0.437699968161302 0.33788936677318 no 1141 0.330801896291567 1517 2858091 SGTC_215 1287-0124 461.5 µM 0.435760788679 0.338564236544998 no 1142 0.331505147976718 1669 5560863 SGTC_1130 3454-2858 15.9 µM 0.434180287445207 0.339114663583201 no 1143 0.332078763304042 1533 715628 YIL048W NEO1 SGTC_213 1246-0773 967 nM 0.434085356349042 0.339147735336818 no 1144 0.332113229435255 1598 6251622 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.433915185522638 0.339207021938847 no 1145 0.332175016012362 1510 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2016 5121758 140 µM 0.433227789054006 0.339446547686257 no 1146 0.332424646196852 1528 2795203 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.432648945558244 0.339648298086075 no 1147 0.332634912698289 1599 5379071 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.431902850078657 0.339908410358179 no 1148 0.33290601162643 1564 6708784 An antioxidant flavonoid SGTC_140 0062-0056 502.533 µM 0.430967103653326 0.340234748652175 no 1149 0.333246145026612 1484 3758964 SGTC_338 4055-0136 114 µM 0.427583337285045 0.341415822882255 no 1150 0.334477249693426 1546 2900563 SGTC_2889 9059656 51.95 µM 0.426647821848734 0.341742631257608 no 1151 0.334817930239786 1647 3949838 SGTC_1614 st002383 48.6 µM 0.426198930490339 0.341899486903581 no 1152 0.334981448375671 1586 1947235 SGTC_490 phenamil 164 µM 0.424676732824384 0.342431589939547 no 1153 0.335536173719859 1665 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2667 digitoxin 100 µM 0.423688865522347 0.342777078682932 no 1154 0.335896368265103 1635 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3091 9116372 49.47 µM 0.423317188279383 0.342907100154499 no 1155 0.336031927663172 1595 17169793 SGTC_1397 3532-0190 20.1 µM 0.42288688863884 0.343057652364343 no 1156 0.336188894664003 1607 5322280 SGTC_2299 7976368 114.88 µM 0.421038697342494 0.343704576219686 no 1157 0.336863412293649 1703 2979718 SGTC_1029 k015-0030 64.7 µM 0.420707754809634 0.343820464694353 no 1158 0.336984248875602 1640 2208316 SGTC_2464 5717415 7.67 µM 0.419749954654616 0.344155946981032 no 1159 0.337334063874409 1508 5285744 SGTC_1321 1326-2144 215 µM 0.418392461485405 0.344631637207728 no 1160 0.337830098673979 1680 3513030 SGTC_3036 9090181 49.47 µM 0.417980319094614 0.344776108048741 no 1161 0.337980753369094 1609 25236586 SGTC_770 0389-1121 67.2 µM 0.417931203116333 0.344793326488789 no 1162 0.337998708974816 1717 6753108 SGTC_856 0433-0016 11.3 µM 0.41596643174347 0.345482373761198 no 1163 0.338717283442621 1601 3911780 SGTC_2007 4011539 71.82 µM 0.414634188046145 0.34594988459288 no 1164 0.339204858392622 1569 45595301 SGTC_2950 9072895 21.46 µM 0.413565484047986 0.346325083966489 no 1165 0.339596177777208 1537 17332245 SGTC_1747 st037496 66.6 µM 0.41259243356704 0.346666832639131 no 1166 0.339952622896016 1603 723305 SGTC_1383 3049-0032 20.7 µM 0.412533819462749 0.346687422704797 no 1167 0.339974098823483 1715 712864 SGTC_337 1315-0038 354 µM 0.411852402772763 0.34692682517994 no 1168 0.340223804734356 1603 1626437 SGTC_1163 k060-0048 49.9 µM 0.410055318994805 0.347558488475726 no 1169 0.340882684009549 1607 6809982 SGTC_225 nsc-122657 1.016 µM 0.409801601560967 0.347647702664932 no 1170 0.340975745640853 1642 275685 SGTC_2214 7179297 48.276 µM 0.408562392055823 0.348083564769327 no 1171 0.34143041724977 1667 769744 SGTC_1053 3366-3204 134 µM 0.407856498790378 0.34833193552133 no 1172 0.341689515677098 1572 3632071 YPR165W RHO1 SGTC_196 k015-0023 18.111 µM 0.407192593077673 0.348565592188518 no 1173 0.341933270638506 1609 5211998 SGTC_152 4469-0003 551.229 µM 0.398053921555499 0.351787684936114 no 1174 0.345295219535335 1658 697280 SGTC_1010 4112-3296 15.2 µM 0.396780446912518 0.352237536462534 no 1175 0.345764685396895 1791 704384 SGTC_2575 plumbagin 510 nM 0.396268918515278 0.352418290766475 no 1176 0.345953326945682 1562 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1776 st049249 45.9 µM 0.396142259470263 0.352463052312999 no 1177 0.346000042203125 1577 1822314 SGTC_2492 derrusnin 100 µM 0.394644730829738 0.352992436515373 no 1178 0.346552548502729 1583 1715307 Part of coumarin class of compounds. SGTC_1372 2752-0194 270 µM 0.394198363829576 0.353150284704283 no 1179 0.346717296787998 1577 823334 SGTC_356 1634-0012 32.5 µM 0.39372286040317 0.353318464168487 no 1180 0.346892830842135 1773 735457 SGTC_873 0591-4978 488 µM 0.393642529464491 0.35334687902085 no 1181 0.346922488586077 1783 3305145 SGTC_3220 9131269 49.47 µM 0.393335080158103 0.35345563827752 no 1182 0.34703600585337 1633 17722206 SGTC_1561 5-methoxyflavone 52.9 µM 0.392991163865104 0.353577311799102 no 1183 0.347163003827657 1673 94525 SGTC_1003 4049-0218 100 µM 0.392613385944219 0.353710982408868 no 1184 0.347302525669347 1684 295161 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.392521906698528 0.353743353574525 no 1185 0.347336314115408 1640 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2995 9067767 71.4286 µM 0.391389759646808 0.354144066554938 no 1186 0.347754580238763 1655 11673567 SGTC_1741 st038134 10.228 µM 0.390204898294045 0.354563610306852 no 1187 0.348192519919598 1761 1272587 SGTC_2779 methotrexate 400 µM 0.389754394075718 0.354723174240204 no 1188 0.348359085121881 1642 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2583 asiatic acid 100 µM 0.388724855149359 0.355087921934999 no 1189 0.348739846937327 1674 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3219 9131112 49.47 µM 0.388144025710082 0.355293758310695 no 1190 0.348954726553663 1644 17612988 YMR079W SEC14 SGTC_1946 st076057 65.1 µM 0.387742378263121 0.355436120241542 no 1191 0.349103345586238 1589 953009 SGTC_1863 st057641 20.1 µM 0.387088614502318 0.35566788667456 no 1192 0.349345303096286 1698 3921635 SGTC_1091 telmisartan 47.6 µM 0.386915364507655 0.355729314649305 no 1193 0.349409433066138 1715 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_89 0302-0250 142.109 µM 0.386713473182808 0.355800902496386 no 1194 0.349484170293396 1699 4203518 YLR208W SEC13 SGTC_607 4491-0986 66.8 µM 0.385811830659806 0.356120674394728 no 1195 0.349818016405763 1759 698981 YDR232W HEM1 SGTC_1423 4048-0112 5.59 µM 0.385725444276646 0.356151317062052 no 1196 0.349850008307715 1731 X1423 SGTC_2477 5967686 25.23 µM 0.385503744325753 0.356229961922927 no 1197 0.349932116438977 1595 776118 SGTC_3112 9123419 49.47 µM 0.383775329307684 0.356843301698247 no 1198 0.350572487420545 1670 17015854 SGTC_2161 5662504 8.5105 µM 0.380209679199553 0.358109765076827 no 1199 0.351894887428394 1634 2859334 SGTC_284 0988-0104 32.6 µM 0.379532019082668 0.358350636563894 no 1200 0.352146415947492 1721 4666532 SGTC_1399 3562-5772 25 µM 0.379494647482689 0.358363921785698 no 1201 0.352160289125535 1635 23847490 SGTC_1312 1218-2183 165 µM 0.379047533880883 0.358522879392716 no 1202 0.352326282999627 1692 6744073 SGTC_2528 xanthyletin 44.79 µM 0.378485725780511 0.358722647883404 no 1203 0.352534897845424 1649 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1663 st014140 55.4 µM 0.377331998477539 0.359133012961719 no 1204 0.352963447657333 1728 4207120 SGTC_1291 0993-0025 5.79 µM 0.376991901000387 0.359254012048039 no 1205 0.353089811851618 1752 4353356 SGTC_693 4161-2696 114 µM 0.376928470527462 0.359276580755998 no 1206 0.353113381419121 1752 805759 SGTC_1277 0873-0036 22 µM 0.372186897026801 0.360965028729954 no 1207 0.354876850565722 1773 5965735 SGTC_910 3454-3003 490 µM 0.371754498918536 0.361119138767779 no 1208 0.355037822023889 1731 820824 SGTC_2158 5657123 3.6195 µM 0.370585601245443 0.361535855746298 no 1209 0.355473104085563 1698 2858827 SGTC_2029 5175081 200 µM 0.370466147728996 0.361578450692589 no 1210 0.35551759762807 1640 1380876 SGTC_1852 st056254 31.4 µM 0.368032585408276 0.362446587432609 no 1211 0.356424468566306 1727 442583 SGTC_2260 7964312 200 µM 0.366956358045452 0.362830741347207 no 1212 0.356825785853296 1781 231951 SGTC_2695 st077686 51.995 µM 0.366240142347011 0.363086467470727 no 1213 0.357092945307305 1627 2876092 SGTC_1642 st009582 77.7 µM 0.36510613618148 0.363491491267509 no 1214 0.357516090311254 1799 6739311 SGTC_1817 st052116 64.4 µM 0.363949937314154 0.363904598605655 no 1215 0.357947696744438 1736 4361398 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.363577118337887 0.364037839774373 no 1216 0.358086907984638 1735 5377381 SGTC_3350 9150499 3.57 µM 0.363400089058505 0.364101113738048 no 1217 0.358153017627707 1664 4910996 YPR165W RHO1 SGTC_3279 9140807 49.47 µM 0.363368374369356 0.364112449622019 no 1218 0.35816486157986 1676 45595718 SGTC_1198 1612-1005 86.7 µM 0.36300900263862 0.364240909327223 no 1219 0.358299079636381 1774 6998509 SGTC_3280 9140961 49.47 µM 0.359050024282084 0.365657077910336 no 1220 0.359778833469942 1676 4901226 SGTC_1925 st057770 10.1 µM 0.358951256201557 0.365692431815227 no 1221 0.359815777173096 1579 5989122 SGTC_2864 9034755 47.6 µM 0.357584577056551 0.36618174981204 no 1222 0.360327110941131 1719 4930451 SGTC_2152 5568786 200 µM 0.357448999529608 0.366230303097128 no 1223 0.3603778499982 1710 5399883 SGTC_1164 k060-0068 93.7 µM 0.35728925255204 0.366287514740842 no 1224 0.360437637479311 1693 5963676 SGTC_641 4092-0595 30 µM 0.356302043601441 0.366641138790915 no 1225 0.360807189524645 1745 786260 SGTC_978 1416-0512 87.4 µM 0.356088048056754 0.366717808195846 no 1226 0.36088731382677 1709 6814003 SGTC_1636 st007707 68.9 µM 0.355965628387413 0.366761670580802 no 1227 0.360933152996775 1813 403051 SGTC_483 fpl-64176 144 µM 0.355104521086297 0.367070250359302 no 1228 0.36125564487935 1713 3423 SGTC_2274 7947094 46.08 µM 0.354849771366682 0.367161556979698 no 1229 0.361351069693282 1640 2971028 SGTC_181 1447-1644 8.07 µM 0.354510028749843 0.367283338186633 no 1230 0.361478344791116 1809 534600 SGTC_710 3448-4187 58 µM 0.354402048274483 0.367322046732788 no 1231 0.361518799876338 1687 3946412 SGTC_366 0181-0206 4.31 µM 0.353790600560086 0.367541262265505 no 1232 0.361747909088142 1860 274874 SGTC_1643 st009866 20.2 µM 0.353784304862053 0.367543519616582 no 1233 0.361750268341591 1782 3156273 YOR207C RET1 SGTC_2732 terfenadine 20 µM 0.352109483479989 0.368144196742169 no 1234 0.362378078239575 1729 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_449 xestospongin c 11.1929 µM 0.35160482984234 0.368325254799046 no 1235 0.362567321268444 1755 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2062 5245942 200 µM 0.351410191047752 0.368395094515475 no 1236 0.362640318988306 1706 1376160 SGTC_1943 st076331 65.2 µM 0.349657483126502 0.369024191612522 no 1237 0.363297882676527 1760 24208415 SGTC_473 2-arachidonoylglycerol 10 µM 0.347975911711566 0.369628085768537 no 1238 0.363929136994147 1666 5282280 An endocannabinoid. SGTC_2300 7976697 71.57 µM 0.347586023042096 0.369768150496288 no 1239 0.364075552263664 1635 2236109 SGTC_1740 st038286 13.222 µM 0.343031748698681 0.371405516423128 no 1240 0.365787287818938 1744 716786 SGTC_333 3486-0131 40.1 µM 0.342955027561773 0.371433119465566 no 1241 0.365816146662554 1844 6744690 SGTC_3010 9080089 71.4286 µM 0.341669910488613 0.371895582304726 no 1242 0.366299659368436 1799 17027233 SGTC_2490 carminic acid 95.39 µM 0.339597789925122 0.372641645754483 no 1243 0.367079721355715 1722 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_432 NS 1619 61.3 µM 0.337632574507769 0.37334965998967 no 1244 0.367820045667203 1735 4552 A K+/calcium channel activator. SGTC_409 arachidonic acid 100 µM 0.337314794010918 0.373464187995494 no 1245 0.367939804273461 1728 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_738 1315-0003 72.4 µM 0.337031730466191 0.373566213434131 no 1246 0.368046490276753 1809 6251474 SGTC_1084 voriconazole 435 nM 0.336037314230287 0.373924704056833 no 1247 0.368421364121475 1847 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_880 0833-0487 87.2 µM 0.335733819110298 0.374034136877274 no 1248 0.368535800318641 1680 76075 SGTC_1956 st077085 54 µM 0.334349121417392 0.374533553266194 no 1249 0.369058063753467 1695 24208685 SGTC_1464 k208-0027 110 µM 0.330346359971312 0.375978403279968 no 1250 0.370569133508479 1837 X1464 SGTC_1008 4106-0037 6 µM 0.328863046216983 0.376514268170795 no 1251 0.371129603466199 1747 2905394 SGTC_995 3931-2021 34.6 µM 0.327611424503643 0.376966616771235 no 1252 0.371602741384171 1767 730143 SGTC_2360 9040895 200 µM 0.326189835212875 0.377480598222692 no 1253 0.372140365756855 1703 4914414 SGTC_1343 1487-0095 224 µM 0.325080916186232 0.377881683210793 no 1254 0.372559915959774 1860 4560101 YGL055W OLE1 SGTC_402 epigallocatechin gallate 10 µM 0.323828163584951 0.378334949767842 no 1255 0.373034066337684 1706 65064 An antioxidant. SGTC_1011 4112-3381 17.4 µM 0.323028165454919 0.378624489950875 no 1256 0.37333695580491 1782 2877139 SGTC_3273 9137859 49.47 µM 0.321592860273648 0.379144135033643 no 1257 0.373880576706571 1786 2377234 SGTC_2649 anisomycin 9.56 µM 0.320986989143344 0.379363553283942 no 1258 0.374110125393942 1759 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_983 1491-0821 12.2 µM 0.319225436689081 0.38000172590789 no 1259 0.374777784773398 1857 46495113 SGTC_3014 9081533 49.47 µM 0.31835675372723 0.380316551545805 no 1260 0.375107169281191 1869 21367265 SGTC_2223 6903751 107.57 µM 0.318313389067714 0.380332269723701 no 1261 0.37512361454745 1817 5598863 SGTC_2566 crystal violet carbinol 226 nM 0.316972239039829 0.380818487310517 no 1262 0.37563233348343 1634 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2624 nerol 100 µM 0.316727986158904 0.380907058502906 no 1263 0.375725005685098 1831 637566 A natural product oil. SGTC_3321 9137793 26.8275 µM 0.316335994779064 0.381049215801196 no 1264 0.375873746465183 1753 4904192 SGTC_661 1304-0007 33.6 µM 0.316040460078722 0.381156403301473 no 1265 0.375985899040644 1723 3117130 SGTC_1873 rapamycin 2 nM 0.31544825218945 0.381371218656242 no 1266 0.376210667756046 1722 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3231 9132313 49.47 µM 0.313683376966706 0.382011619674714 no 1267 0.376880763628621 1778 4905967 SGTC_2051 5263410 176 µM 0.312128722398063 0.382576007848639 no 1268 0.377471349434465 1828 227584 SGTC_1316 1272-0050 65.9 µM 0.310567812553807 0.383142917896193 no 1269 0.378064599892275 1773 7340392 SGTC_2359 9039622 200 µM 0.310033238925626 0.383337128403742 no 1270 0.378267839927569 1828 6463596 SGTC_160 3453-0671 289.699 µM 0.309659216669653 0.383473028062188 no 1271 0.378410059823496 1709 5322268 SGTC_2332 7982454 138.89 µM 0.309445133127765 0.383550821009904 no 1272 0.378491471321168 1766 2981748 SGTC_2652 actinonin 100 µM 0.308923642767031 0.383740338038991 no 1273 0.378689805772575 1796 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2348 9022543 33.42 µM 0.30886647851237 0.38376111403605 no 1274 0.378711548561785 1793 3162678 YDL140C RPO21 SGTC_2723 salbutamol 83.58 µM 0.308449657058197 0.383912615329454 no 1275 0.378870100864029 1846 9884233 β2-adrenoceptor agonist SGTC_261 5-fluorouridine 15.376 µM 0.30583302514352 0.384864081948757 no 1276 0.379865891019117 1854 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2140 5586273 200 µM 0.305778214785309 0.384884019674342 no 1277 0.379886758293705 1766 854421 SGTC_918 glabranin 770.725 nM 0.304705919258106 0.385274137296461 no 1278 0.380295070480533 1803 124049 Also referred to as licorice root. SGTC_369 0957-0393 4.5 µM 0.304077096807563 0.385502966629857 no 1279 0.380534577637901 1710 6997992 SGTC_201 4262-0159 12.803 µM 0.302647162131966 0.38602347004705 no 1280 0.381079384385082 1901 1341029 SGTC_2676 harmalol 100 µM 0.299965552723535 0.387000142041524 no 1281 0.382101715650449 1856 5459187 A monoamine oxidase inhibitor SGTC_1315 1237-0019 3.69 µM 0.299896483802729 0.387025307194652 no 1282 0.382128058240345 1872 825140 SGTC_510 ag-490 170 µM 0.299126156001046 0.387306007084271 no 1283 0.382421894910607 1875 5328779 SGTC_362 0310-0100 9.03 µM 0.297840540320055 0.387774604002135 no 1284 0.382912435615091 1759 790235 SGTC_3067 9117431 49.47 µM 0.293985360238034 0.389180764863812 no 1285 0.38438454508324 1770 17150885 SGTC_3052 9092717 49.47 µM 0.293587962701699 0.389325796854301 no 1286 0.384536387505917 1767 25237534 SGTC_2459 5811157 9.22 µM 0.292713818722077 0.389644873802998 no 1287 0.384870453250551 1816 2870684 YBR192W RIM2 SGTC_1394 3474-0001 65.7 µM 0.292369997302223 0.389770394681499 no 1288 0.385001872615938 1760 5017666 YIL048W NEO1 SGTC_1850 st056238 17 µM 0.291766938567072 0.389990584590982 no 1289 0.385232412540242 1787 5393177 SGTC_2880 9042983 58.44 µM 0.291479560259415 0.390095525109612 no 1290 0.385342287050284 1790 6464714 SGTC_460 trequinsin 123 µM 0.289889486029459 0.39067630924404 no 1291 0.385950392682446 1834 5537 A vasodilator. SGTC_1380 2291-0730 164 µM 0.285253600444965 0.392370982432561 no 1292 0.387724929062573 1764 2999191 SGTC_2076 5212012 200 µM 0.284976828922084 0.392472222713993 no 1293 0.387830947016849 1818 604802 SGTC_3302 9125395 16.351 µM 0.284241331596453 0.392741295697724 no 1294 0.388112721539404 1813 17599668 SGTC_234 nsc-17383 10.7 µM 0.28369111362464 0.392942619954622 no 1295 0.388323552685896 1905 408974 SGTC_120 rhodamine 6G 52.259 µM 0.283641640949968 0.392960723365586 no 1296 0.38834251111519 1777 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1216 1165-0504 9.65 µM 0.283016973267951 0.393189326338164 no 1297 0.388581912961004 1931 6304004 SGTC_2512 diallyl trisulfide 49.23 µM 0.281801216403251 0.393634349460096 no 1298 0.389047969081648 1870 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2342 7990637 118.86 µM 0.280067926844053 0.394269053606967 no 1299 0.389712695527234 1825 2033102 YER133W GLC7 SGTC_3110 9122132 49.47 µM 0.278846590105896 0.394716457238204 no 1300 0.390181279093101 1924 918317 SGTC_277 nystatin 15.5 µM 0.278771376624757 0.394744014205694 no 1301 0.39021014106067 1755 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2486 5283202 22.39 µM 0.278098593780433 0.394990534049394 no 1302 0.39046833759046 1743 1377751 SGTC_2702 st077768 96.8 µM 0.277569708098614 0.395184356882628 no 1303 0.390671344061262 1776 6484119 SGTC_1795 st049545 62.3 µM 0.274678780711623 0.396244263654007 no 1304 0.391781517430627 1973 5291882 SGTC_2367 9070478 135.38 µM 0.274291490197802 0.396386315245773 no 1305 0.39193031183391 1791 572802 SGTC_2370 9071495 200 µM 0.273368176424852 0.39672502653339 no 1306 0.392285106483727 1786 21791103 SGTC_3213 9129884 49.47 µM 0.269804262478081 0.398033152630971 no 1307 0.393655421707195 1723 17190742 SGTC_3239 9133757 49.47 µM 0.269385255797886 0.398187023668951 no 1308 0.393816615553638 1896 17036923 SGTC_297 0986-0032 24 µM 0.266862695111717 0.399113712710934 no 1309 0.394787440138142 1830 2847425 SGTC_1109 tnp00067 928.257 nM 0.265366315020333 0.399663692738958 no 1310 0.395363641457985 1818 676295 SGTC_1860 st056228 74.6 µM 0.264759640176042 0.399886727006389 no 1311 0.395597315049241 1796 688679 SGTC_2383 9036125 200 µM 0.264146743675588 0.400112081734958 no 1312 0.395833423157868 1859 79580 SGTC_2000 st075254 36.4 µM 0.263920934474901 0.400195117472994 no 1313 0.395920422010347 1825 17234175 SGTC_1905 st060207 84.5 µM 0.261581412317239 0.401055683655499 no 1314 0.396822087995067 1835 1948547 SGTC_2047 4141938 200 µM 0.260974263025131 0.401279095169517 no 1315 0.397056177398848 1844 3807862 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.259773201610127 0.401721142366382 no 1316 0.397519361743691 1816 442882 SGTC_2270 7924575 90.91 µM 0.258602232873931 0.402152235137998 no 1317 0.397971080127946 1993 1262135 SGTC_3355 9151058 44.0485 µM 0.258401368074715 0.402226195598925 no 1318 0.398048580436355 1928 17015728 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.25731629834563 0.402625789771728 no 1319 0.398467305847774 1831 689007 SGTC_1075 aripiprazole 15.2 µM 0.256912587836116 0.402774488576758 no 1320 0.398623126487826 1827 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1930 st074634 34.3 µM 0.256764823845622 0.402828918046004 no 1321 0.398680163177978 1760 684253 YOR116C RPO31 SGTC_1928 4'-methoxychalcone 40.3 µM 0.256640802956733 0.402874603100522 no 1322 0.398728036735129 2028 641818 SGTC_1061 3448-9325 110 µM 0.256636284649431 0.402876267515466 no 1323 0.39872978088495 1970 723482 SGTC_1685 st024049 53.0905 µM 0.256362860355179 0.402976992465671 no 1324 0.398835331460656 1884 1941139 SGTC_759 3486-0358 89.3 µM 0.256108677558468 0.403070634944344 no 1325 0.398933460835539 1995 875103 SGTC_2764 methyldopa 94.69 µM 0.255947978893328 0.403129840172626 no 1326 0.398995503183253 1968 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_293 4049-0273 38.5 µM 0.253001181079046 0.404215903310331 no 1327 0.400133650257492 1892 1380311 SGTC_843 0310-0051 143 µM 0.252663241817825 0.404340500578579 no 1328 0.400264227582172 1870 2065037 SGTC_1516 st013856 110 µM 0.25262993075448 0.404352782800803 no 1329 0.400277099343819 1883 5281404 A mutagen and neurotoxin. SGTC_2860 9025725 38.96 µM 0.252356713494523 0.40445352511376 no 1330 0.400382677587862 1776 40546248 SGTC_25 0118-0223 35.662 µM 0.251268518702358 0.404854833651042 no 1331 0.400803256477977 1938 5333628 SGTC_1996 st072960 66.8 µM 0.251067009445742 0.404929157982568 no 1332 0.400881150885608 1990 1719405 SGTC_2656 pseudo-anisatin 100 µM 0.250198877602391 0.405249397438426 no 1333 0.401216776601262 1885 6708809 A neurotoxin. SGTC_806 3966-4455 5.86 µM 0.249210971111458 0.40561389695055 no 1334 0.40159879669266 1798 714982 SGTC_1442 4112-3290 3 µM 0.248667331901401 0.405814513855442 no 1335 0.401809060278579 1888 704353 SGTC_66 0109-0187 42.4 µM 0.247393188038047 0.406284802686871 no 1336 0.402301972767344 1743 759417 SGTC_1564 D-Arginine 115 µM 0.247192837986018 0.406358764579106 no 1337 0.402379493905134 1773 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2378 9074213 121.43 µM 0.247169986717273 0.406367200641887 no 1338 0.402388335955417 1855 657714 SGTC_393 acivicin 6.25 µM 0.24674305750444 0.406524819205897 no 1339 0.40255354075591 1878 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_144 4161-2749 112.381 µM 0.246157516168335 0.406741020618272 no 1340 0.402780150502878 1919 797501 YMR168C CEP3 SGTC_2841 9004761 38.96 µM 0.246115719608058 0.406756454391689 no 1341 0.402796327396355 1735 2991039 SGTC_2328 6201408 200 µM 0.246082219336389 0.406768824786984 no 1342 0.402809293423803 1837 2890418 SGTC_2431 5490079 200 µM 0.24589087920974 0.406839481310177 no 1343 0.402883352224842 1840 5722345 SGTC_3226 9131256 49.47 µM 0.245640533881641 0.40693193137257 no 1344 0.402980254437222 1893 17178073 SGTC_731 3966-0296 387 µM 0.244592312848068 0.40731908533231 no 1345 0.403386058380972 1868 660956 SGTC_834 0312-0008 75.7 µM 0.242648042837765 0.408037428937003 no 1346 0.40413903019285 1872 6385573 YIL048W NEO1 SGTC_2294 7971431 200 µM 0.241610516051423 0.408420887532113 no 1347 0.404540986422218 1939 5741572 SGTC_1059 3448-6867 171 µM 0.24132237363111 0.408527397407334 no 1348 0.40465263578985 2039 3934407 SGTC_2386 9075165 157.42 µM 0.239979558289388 0.409023848913236 no 1349 0.405173051868315 1909 16452277 SGTC_547 1120-0019 610 nM 0.239321643882377 0.409267139410538 no 1350 0.405428091789565 1869 3676939 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.238536651588558 0.409557467827364 no 1351 0.4057324458739 1908 91467 include heat shock SGTC_1002 4049-0206 172 µM 0.238218957563073 0.409674980673997 no 1352 0.40585563714653 1841 4662749 SGTC_1942 st076330 65.2 µM 0.238147372173547 0.409701460740468 no 1353 0.40588339688884 1942 24208414 SGTC_2066 5222451 176 µM 0.237592930589181 0.409906567509346 no 1354 0.406098417051424 1907 2281147 SGTC_797 k781-0471 270 µM 0.23755526719797 0.409920501371552 no 1355 0.406113024466881 1937 23738129 SGTC_2429 5902844 64.44 µM 0.23725869979799 0.410030222742545 no 1356 0.406228050092692 2007 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2903 5923464 63.88 µM 0.236175192288398 0.410431149043486 no 1357 0.406648364372272 2022 2876576 SGTC_1627 st003713 25.6 µM 0.23617140641384 0.41043255008111 no 1358 0.406649833177753 1851 16195070 YER133W GLC7 SGTC_3336 9143619 71.43 µM 0.235475200581168 0.410690214209158 no 1359 0.406919962410879 1985 45595730 SGTC_1182 1222-0449 220 µM 0.234490865066434 0.411054580202681 no 1360 0.407301962073338 1921 658318 SGTC_766 1391-0721 126 µM 0.232713071579019 0.411712850399165 no 1361 0.407992109104138 1986 1020919 YIL115C NUP159 SGTC_2134 5324836 1.464 µM 0.232098143456387 0.411940600069539 no 1362 0.408230893409375 1907 699272 SGTC_729 4092-0585 94.1 µM 0.231996198976503 0.411978359906633 no 1363 0.408270483025776 1824 2169061 SGTC_448 monastrol 171 µM 0.2308654651042 0.41239723389165 no 1364 0.408709660432413 1970 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1346 1488-2224 62.4 µM 0.229682650386283 0.412835507729405 no 1365 0.409169188752339 2008 3722427 SGTC_796 1234-0020 70.7 µM 0.228623539190423 0.413228037367301 no 1366 0.409580763723303 1879 46495034 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.228089303971437 0.41342606949759 no 1367 0.409788407573793 1890 115019 SGTC_614 0462-0418 107 µM 0.226901912876263 0.413866294481127 no 1368 0.4102500072933 1946 5188303 SGTC_2749 bexarotene 57.39 µM 0.226385611429045 0.4140577469332 no 1369 0.410450758939639 1853 82146 An retinoic acid receptor inhibitor. SGTC_3070 9117005 49.47 µM 0.225803492049941 0.414273630174483 no 1370 0.410677130478271 1985 8779016 SGTC_2919 7978188 46.38 µM 0.225231271376875 0.414485867654575 no 1371 0.410899681662843 2025 2980291 SGTC_3087 9117406 49.47 µM 0.2241218245815 0.414897434169666 no 1372 0.411331255420909 1900 42546093 SGTC_2496 diffractaic acid 79.83 µM 0.223940333559837 0.414964769985529 no 1373 0.411401865485223 2022 94870 An apoptosis inducer which activates caspases. SGTC_2081 5214970 32.255 µM 0.223667713966328 0.415065920524697 no 1374 0.411507935006095 1997 2063512 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.223608448298079 0.415087910717684 no 1375 0.411530994663523 1910 65057 A dermal irritant. YDR527W RBA50 SGTC_3097 9117246 49.47 µM 0.223592993868648 0.415093645040566 no 1376 0.411537007872119 1906 16423892 SGTC_2952 9073731 13.78 µM 0.221764514870896 0.41577222441035 no 1377 0.412248602333226 1872 16457353 SGTC_757 1066-0008 322 µM 0.219141781497239 0.416746003110748 no 1378 0.413269802372833 1996 6842497 SGTC_3331 9141060 1.957 µM 0.217151728106379 0.417485219268443 no 1379 0.414045051206296 1871 4906567 YPR165W RHO1 SGTC_1984 st072354 53.1 µM 0.215019844288473 0.418277442702527 no 1380 0.414875923447622 1945 5762938 SGTC_2940 9060638 45.86 µM 0.214090487202241 0.418622902505388 no 1381 0.415238246967796 1916 4027022 SGTC_957 1187-1561 14.1 µM 0.213180327585143 0.418961287083752 no 1382 0.4155931559533 2031 1538454 SGTC_1512 0259-0544 12.2 µM 0.212722741787899 0.419131433730699 no 1383 0.415771613668317 1945 18476 SGTC_785 1270-0111 65.3 µM 0.21040080294171 0.419995045493262 no 1384 0.416677433011462 2045 6741994 SGTC_678 1218-2179 85.9 µM 0.210280044560713 0.420039970414792 no 1385 0.416724554617241 1986 6820081 YOR116C RPO31 SGTC_3294 9122953 26.2835 µM 0.20776242700219 0.420976819034049 no 1386 0.417707235661531 1961 16459826 SGTC_2586 curcumin 80 µM 0.207748952085858 0.420981834490351 no 1387 0.417712496603863 2008 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2164 5685496 200 µM 0.207211618687667 0.421181844110931 no 1388 0.417922296914369 2027 759046 SGTC_1867 st057372 64 µM 0.206881215874761 0.421304838829119 no 1389 0.418051313363417 2029 688837 SGTC_1563 conessine 56.1 µM 0.206764000183299 0.421348475022061 no 1390 0.418097086135807 2048 441082 An anti-amoebic, histamine inhibitor. SGTC_2400 5203494 178.7 µM 0.206605787361911 0.421407374855921 no 1391 0.418158870062244 1967 6777674 SGTC_620 0109-0052 432 µM 0.206220767862953 0.4215507181474 no 1392 0.41830923303959 2040 493037 SGTC_3123 9126162 49.47 µM 0.205635379081285 0.421768679113748 no 1393 0.418537869784639 1908 25239884 SGTC_3296 9122258 64.045 µM 0.205627778073066 0.421771509395956 no 1394 0.418540838710406 1933 4730474 SGTC_657 3534-0529 86.7 µM 0.205284895386489 0.421899188075749 no 1395 0.418674772246281 2035 1049549 SGTC_550 4123-0385 25.7 µM 0.205265381029119 0.421906454852958 no 1396 0.418682395040483 1929 5731123 SGTC_1076 itraconazole 331 nM 0.20489886959353 0.422042941708985 no 1397 0.418825569208221 2048 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_902 1120-0002 2.07 µM 0.2040012734337 0.422377241127557 no 1398 0.419176251890419 1929 3280475 SGTC_1505 k297-0037 20.6 µM 0.203599065813297 0.422527056911775 no 1399 0.419333411613037 1900 4089396 SGTC_1004 4084-0029 199 µM 0.203577031220937 0.422535264762375 no 1400 0.419342021842928 2057 716894 YLR208W SEC13 SGTC_765 1319-0117 244 µM 0.201916399273714 0.423153944061938 no 1401 0.419991040680194 1970 3487746 YGL099W LSG1 SGTC_3075 9116269 49.47 µM 0.201502748973066 0.423308081735488 no 1402 0.420152740073769 1963 17015205 YNL244C SUI1 SGTC_922 1866-0035 480 µM 0.201450606537471 0.423327512299203 no 1403 0.420173123949049 1926 3156169 SGTC_776 4476-4378 112 µM 0.201312704633671 0.423378901509414 no 1404 0.420227034530274 1899 2892008 SGTC_1460 k062-0059 9.15 µM 0.201196876703081 0.42342206585019 no 1405 0.420272316795228 1893 1373085 SGTC_3169 9102970 49.47 µM 0.198136379778066 0.424562919515262 no 1406 0.421469181040218 2020 17027839 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.197518313627563 0.424793391508151 no 1407 0.421710975763026 2009 688761 SGTC_1363 1636-0063 10.4 µM 0.195615563518003 0.425503073100148 no 1408 0.422455538849942 1951 6072185 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.19450083394212 0.425918953638035 no 1409 0.42289187140265 2000 4620898 SGTC_2218 6965428 192.983 µM 0.193920403563353 0.426135531817257 no 1410 0.423119103609385 2040 675684 SGTC_3329 9141233 27.5565 µM 0.192011709821318 0.426847886678343 no 1411 0.423866516492026 2047 4909101 YNL103W MET4 SGTC_1745 st081495 74 µM 0.191984501455434 0.426858043003932 no 1412 0.423877172824625 1961 13842402 YBL026W LSM2 SGTC_1103 duloxetine 36.1 µM 0.190465122396389 0.427425272849433 no 1413 0.424472335591773 2058 60835 A selective serotonin reuptake inhibitor. SGTC_1448 4255-0083 152 µM 0.190318878747935 0.427479877932072 no 1414 0.424529630454546 2052 5399660 SGTC_1990 st072050 59.8 µM 0.189803790034228 0.427672215028949 no 1415 0.424731442933893 1900 17233948 SGTC_2187 6125751 200 µM 0.189260223547207 0.427875204531226 no 1416 0.42494443444148 2002 874498 SGTC_771 0250-0039 27.3 µM 0.18749663878507 0.428533928909817 no 1417 0.425635629410178 1956 3005115 SGTC_2381 9035592 200 µM 0.186815667258867 0.428788335006005 no 1418 0.42590258123984 1906 4749657 SGTC_1319 1306-0155 43.7 µM 0.18679561645994 0.428795826290183 no 1419 0.425910441991969 2004 3122360 SGTC_1912 st060209 90.8 µM 0.186050042096221 0.429074402427921 no 1420 0.426202759213635 1921 688787 SGTC_1037 k284-1091 78.7 µM 0.184654709615965 0.429595848785707 no 1421 0.426749935834189 1989 3334711 SGTC_2682 pyrogallin 40.03 µM 0.183863609058796 0.429891543710928 no 1422 0.427060226909336 2051 822798 An ATP competetive kinase inhibitor. SGTC_971 1315-0384 26.7 µM 0.182406590201391 0.430436246160135 no 1423 0.427631827167488 1913 6769120 SGTC_558 k064-0027 21.3 µM 0.182217174153427 0.430507068569424 no 1424 0.427706147796785 2029 5088526 SGTC_2730 imipramine 71.33 µM 0.182072256625803 0.43056125455038 no 1425 0.42776301040198 2092 3696 A tricyclic antidepressant. SGTC_1048 3161-0300 24.5 µM 0.181359647495914 0.430827724584793 no 1426 0.42804264511858 2040 2165101 SGTC_1855 st056195 39.6 µM 0.181024339206132 0.430953119247707 no 1427 0.428174235847791 2102 4028379 SGTC_1168 k815-0004 80.5 µM 0.179227154442247 0.431625327666012 no 1428 0.428879671383853 1983 642433 SGTC_3108 9121785 49.47 µM 0.178852594434095 0.431765450892589 no 1429 0.429026723322474 2107 17140271 SGTC_260 nsc-65238 3.989 µM 0.178551735187063 0.431878008818716 no 1430 0.429144847540847 2055 3246252 SGTC_952 1185-0122 232 µM 0.17756650942119 0.432246641665083 no 1431 0.429531714059679 2041 678600 SGTC_1966 st070145 16.1 µM 0.176906699896152 0.432493549517456 no 1432 0.429790837936736 2014 3748532 SGTC_1283 0922-0125 16.4 µM 0.17563202728944 0.432970620357057 no 1433 0.430291519653089 2071 3360884 SGTC_840 0245-0196 390 µM 0.172798762932086 0.434031373232708 no 1434 0.431404804727 2090 3827528 SGTC_2774 tamoxifen 10.92 µM 0.172355245517793 0.434197466030315 no 1435 0.431579127241338 2070 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_745 0469-0705 296 µM 0.171857696313339 0.434383807013166 no 1436 0.431774702565149 2104 3486736 SGTC_1403 3909-7815 62.9 µM 0.171580444481055 0.434487649059489 no 1437 0.431883691240297 2007 6615483 SGTC_820 1582-0060 59.9 µM 0.170719398887237 0.43481017431208 no 1438 0.432222204324972 1978 3848840 SGTC_2136 5328288 199.296 µM 0.170625268361167 0.434845435789927 no 1439 0.432259213998975 1982 262395 SGTC_997 3996-0078 137 µM 0.17039882693026 0.434930263311929 no 1440 0.432348247312932 2001 735687 SGTC_2174 5790901 200 µM 0.170351964201033 0.4349478189947 no 1441 0.432366673451898 1985 786020 SGTC_2943 9068529 45.32 µM 0.170313972592239 0.434962051478683 no 1442 0.43238161162845 2081 3270634 SGTC_1570 verbenone 133 µM 0.169036138212747 0.435440805033282 no 1443 0.432884108101716 2119 29025 A natural terpanoid with antifungal properties. SGTC_2505 galangin 7.89 µM 0.166757571193704 0.43629472757865 no 1444 0.433780402208771 1926 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_182 3448-4371 550.524 µM 0.16652075073972 0.436383496222106 no 1445 0.433873577207846 2173 3491403 SGTC_53 0973-0023 39.979 µM 0.166132580045565 0.43652900319189 no 1446 0.434026307620305 2158 674768 SGTC_2987 9018338 71.43 µM 0.165277928313249 0.436849402248924 no 1447 0.434362615273957 2147 5055682 SGTC_2109 5483026 200 µM 0.164490414342526 0.437144668815341 no 1448 0.434672546108381 2006 759335 SGTC_3114 9122766 49.47 µM 0.16425488235299 0.437232984816033 no 1449 0.434765248940327 1974 17176985 SGTC_1126 isoteolin 1.0172 µM 0.163366348583678 0.437566181050696 no 1450 0.435114998421419 2009 133323 SGTC_3268 9137683 49.47 µM 0.162647013033904 0.437835961146595 no 1451 0.4353981843845 1995 1953228 SGTC_621 3584-0052 32.1 µM 0.161548361421383 0.438248055929373 no 1452 0.435830762311335 2124 2273927 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.161131655208935 0.43840437639193 no 1453 0.435994854370648 2099 16486 A toxic proline analog. SGTC_163 TUB2.036 7.546 µM 0.160743400602792 0.438550032352712 no 1454 0.436147752570966 2135 15992207 YJR013W GPI14 SGTC_499 genistein 192 µM 0.160267034447178 0.43872875524006 no 1455 0.436335362936451 2142 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_358 0075-0058 9.45 µM 0.159491697246206 0.439019672680454 no 1456 0.436640749614138 2214 1069125 SGTC_2197 6588183 93.1375 µM 0.15879531343214 0.43928099378485 no 1457 0.436915070650146 2048 884136 SGTC_2593 nobiletin 86.24 µM 0.157998727050187 0.439579948788875 no 1458 0.437228900891912 1976 72344 An anti-infammatory. SGTC_754 3474-0146 171 µM 0.157661829552534 0.439706395163629 no 1459 0.437361639917459 1914 24762078 SGTC_2659 sanguinarine 24.21 µM 0.157330383197287 0.439830801585753 no 1460 0.437492238050672 2050 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2093 5331342 194.4 µM 0.15713319132677 0.439904819203621 no 1461 0.437569939799496 2120 33839 SGTC_82 0054-0107 293.755 µM 0.156122446884212 0.440284243504693 no 1462 0.437968252628307 2133 3104697 SGTC_2965 9082772 38.63 µM 0.153685965596013 0.441199101271802 no 1463 0.438928675569602 2153 16459634 SGTC_184 1494-0393 24.714 µM 0.1529071746697 0.441491590600231 no 1464 0.439235738940296 2011 3090647 SGTC_257 daunorubicin 18.5 µM 0.152847631966268 0.441513954278287 no 1465 0.439259217073272 2123 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2481 5478948 45.16 µM 0.152366250132229 0.441694763598131 no 1466 0.439449037367945 2017 77792 SGTC_564 3555-0129 330 µM 0.152134472723112 0.441781824637573 no 1467 0.439540437675736 2158 563260 SGTC_2957 9076800 11.52 µM 0.151706631723446 0.441942539151924 no 1468 0.439709163180575 2002 16459615 SGTC_1486 3970-0793 4.53 µM 0.151513695357735 0.44201501704158 no 1469 0.439785254110205 2157 2844330 SGTC_2853 9015042 58.44 µM 0.150452711366652 0.44241361769327 no 1470 0.440203728422278 2072 6457456 SGTC_2921 7974240 10.71 µM 0.1492999502642 0.442846764127588 no 1471 0.440658477258264 2083 2979074 YDR527W RBA50 SGTC_2619 obliquin 87.91 µM 0.14786113864672 0.44338748895422 no 1472 0.441226178943984 2105 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2882 9058044 58.44 µM 0.147791628602991 0.443413614444804 no 1473 0.441253608096356 1964 18076804 SGTC_2499 avocadenofuran 51.48 µM 0.147359476074255 0.44357604536116 no 1474 0.441424144841759 2038 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3330 9141424 71.43 µM 0.143613807729251 0.444984304496563 no 1475 0.442902718350348 2141 27261020 SGTC_608 k048-0125 159 µM 0.142643286467441 0.445349305453165 no 1476 0.443285954680284 2142 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1314 1222-0010 41.1 µM 0.14094984555078 0.445986298258607 no 1477 0.443954782060325 2059 3526027 SGTC_1035 k081-0041 55.2 µM 0.140844626311029 0.446025881404439 no 1478 0.443996343866376 2183 731709 SGTC_2025 5147754 141 µM 0.140582957759749 0.446124322618856 no 1479 0.444099706126859 2148 315777 YLR208W SEC13 SGTC_21 0849-0113 22.993 µM 0.140261997861648 0.446245074113279 no 1480 0.44422649438214 2082 1560156 SGTC_3356 9151811 4.48 µM 0.140080042374303 0.446313531599844 no 1481 0.444298374491988 2067 1859254 YPR165W RHO1 SGTC_1447 4239-0816 81.9 µM 0.139860573443931 0.446396104974967 no 1482 0.444385076435192 1987 1341554 SGTC_1838 st055369 84.5 µM 0.139595648388023 0.446495783938629 no 1483 0.44448973951942 2162 676036 SGTC_208 k072-0098 12.366 µM 0.139217088790569 0.446638224155024 no 1484 0.444639302549605 2183 5948901 SGTC_1249 0481-0015 10.2 µM 0.13744305550854 0.447305829204764 no 1485 0.445340300285665 2078 4227577 SGTC_2793 7325131 81.82 µM 0.137281736045808 0.447366544457087 no 1486 0.445404053135823 2083 4176441 SGTC_3189 9110682 49.47 µM 0.137120900235998 0.447427078906507 no 1487 0.445467616253707 2046 17122418 SGTC_2484 5809818 12.04 µM 0.136460773994117 0.447675546206515 no 1488 0.445728516118713 2084 2870548 SGTC_2425 5628681 7.85 µM 0.135514356109986 0.448031807650003 no 1489 0.446102607211267 2100 5714958 SGTC_1793 st048256 72.231 µM 0.135471598991739 0.448047903765337 no 1490 0.446119508975069 2179 672022 SGTC_203 k066-0004 30.888 µM 0.1349384597493 0.448248613678658 no 1491 0.446330265569793 2176 6795412 SGTC_543 3844-1095 191 µM 0.133552869997841 0.448770305840778 no 1492 0.44687807725091 2111 4230703 SGTC_2803 7707263 71.43 µM 0.131696907407275 0.449469238012217 no 1493 0.447612015871865 2062 2199229 SGTC_1684 st024538 14.6195 µM 0.131195227542214 0.449658191352051 no 1494 0.447810435598681 2054 6732859 SGTC_3017 9080681 49.47 µM 0.130479934267943 0.449927620047068 no 1495 0.44809336427591 2054 16451914 SGTC_697 0508-1955 564 µM 0.130391824061166 0.449960810016603 no 1496 0.448128217410832 2176 6243113 SGTC_2405 ticlatone 3.52 µM 0.130185820601333 0.450038410207475 no 1497 0.44820970631293 2212 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_252 miconazole 1.30953 nM 0.129373190290106 0.450344541471853 no 1498 0.448531180214761 2163 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_884 0851-0618 334 µM 0.129033765594597 0.450472417121001 no 1499 0.448665465536787 2166 9642473 SGTC_2836 9010338 19.48 µM 0.129014351965806 0.450479731212235 no 1500 0.448673146256054 1987 2994051 SGTC_403 arphamenine a 50 µM 0.128759247666093 0.450575843405264 no 1501 0.44877407634016 2089 5487158 An arginine aminopeptidase inhibitor. SGTC_1374 2889-5571 141 µM 0.127778921260387 0.450945214632698 no 1502 0.449161965850403 2063 2853281 SGTC_819 1013-0258 27.7 µM 0.127667485830452 0.450987204406053 no 1503 0.449206061017083 2079 5753198 SGTC_2396 5342950 42.78 µM 0.126366094243494 0.451477619789535 no 1504 0.449721069919789 2053 1886677 SGTC_810 3825-7150 143 µM 0.126212756738355 0.451535408266461 no 1505 0.449781756850431 2193 22330411 YGL099W LSG1 SGTC_1811 st050069 61.5 µM 0.122436434209908 0.452958916247979 no 1506 0.451276692615299 2216 3877702 SGTC_1323 1348-1351 11.2 µM 0.122172577911021 0.453058401316353 no 1507 0.451381171699521 2048 6989654 SGTC_511 blebbistatin 171 µM 0.121478029157229 0.453320289862943 no 1508 0.451656208003735 2178 3476986 A myosin inhibitor. SGTC_704 1310-0270 142 µM 0.117674661926944 0.454754755438464 no 1509 0.453162722058669 2077 5718033 SGTC_730 1436-0052 41.2 µM 0.11738609438744 0.454863614954823 no 1510 0.453277051478926 2228 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_972 1319-0219 195 µM 0.117013828031593 0.45500405410507 no 1511 0.453424547788267 2074 23903702 SGTC_2012 4023501 200 µM 0.115589706695629 0.455541362017288 no 1512 0.453988860543902 2087 3477460 SGTC_3211 9128781 49.47 µM 0.115390256532589 0.455616619248861 no 1513 0.454067900768343 1941 17194361 SGTC_380 3970-0968 6 µM 0.115175084035379 0.455697810672202 no 1514 0.454153173645756 2139 2891601 SGTC_1914 st062367 72.6 µM 0.114430317745318 0.455978848932587 no 1515 0.454448340876167 2119 978205 SGTC_2399 5884133 200 µM 0.113474391047908 0.456339601031486 no 1516 0.454827232455366 2089 722445 SGTC_1607 st000305 50.6 µM 0.11315251406965 0.45646108058932 no 1517 0.454954821040755 2191 5457690 SGTC_2821 7996764 71.43 µM 0.112398154550573 0.456745799264106 no 1518 0.455253859256025 2138 2987135 SGTC_1254 0550-0035 264 µM 0.111557357885722 0.457063168161185 no 1519 0.455587192186481 2157 15121435 SGTC_2589 lobaric acid 100 µM 0.110589924350303 0.45742837155306 no 1520 0.455970768838878 2089 73157 A novel microtubule depolymerizer. SGTC_2283 7944793 200 µM 0.110075159845616 0.457622708354603 no 1521 0.456174883998923 2136 2970533 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.109479983356052 0.457847415370162 no 1522 0.45641089864843 2196 279621 SGTC_1430 4049-0248 69.1 µM 0.109260295488534 0.457930361243486 no 1523 0.456498018807633 2204 22774488 SGTC_705 1124-0212 310 µM 0.10645415105954 0.458990015737288 no 1524 0.457611015392681 2226 9554485 SGTC_1467 k284-1082 293 µM 0.106238376009676 0.459071508738763 no 1525 0.457696611784464 2243 3334705 SGTC_709 3807-1509 243 µM 0.103914943062031 0.459949121263842 no 1526 0.458618424230359 2215 1886677 YPL242C IQG1 SGTC_1272 0839-0021 27 µM 0.0999850824574351 0.461433959409856 no 1527 0.460178084283911 2164 5027250 SGTC_2394 5221648 200 µM 0.0993342689086707 0.461679911883572 no 1528 0.460436435152709 2167 788586 SGTC_2900 5328528 85.29 µM 0.0951565858860237 0.463259067677056 no 1529 0.462095226448264 2216 795359 SGTC_1444 4112-3581 28 µM 0.095094363575516 0.463282592024192 no 1530 0.462119937502017 2191 2877249 SGTC_3197 9113331 49.47 µM 0.0946230636936321 0.463460780217542 no 1531 0.462307114925021 2202 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2838 9002687 71.43 µM 0.0943291516605166 0.463571905652517 no 1532 0.462423846738504 2110 6457060 SGTC_303 1348-1668 34.2 µM 0.0927637769079328 0.464163807113801 no 1533 0.463045614362409 2163 5380509 SGTC_2317 5986382 200 µM 0.0901095013265836 0.465167625711992 no 1534 0.464100099485654 2205 877883 SGTC_628 1636-0253 16 µM 0.0894473044468976 0.465418096283825 no 1535 0.464363215296564 2228 4456143 SGTC_2796 7949634 45.45 µM 0.0888014409706857 0.465662402077804 no 1536 0.464619856244153 2209 2971588 SGTC_3019 9081971 49.47 µM 0.0884291989757807 0.465803213069969 no 1537 0.46476777738362 2231 16451803 SGTC_658 3253-0951 102 µM 0.088353488094346 0.465831853362383 no 1538 0.464797863892041 2175 1184878 SGTC_343 4130-2827 29.8 µM 0.0880819002897486 0.465934592415821 no 1539 0.464905790967904 2132 1118244 SGTC_1907 st060210 83.7 µM 0.0880621426940021 0.465942066612869 no 1540 0.464913642597785 2217 688793 SGTC_2536 dehydroabietamide 32.04 µM 0.0875989163875165 0.466117306183548 no 1541 0.465097731733684 2233 3983547 SGTC_1279 0874-0590 65.2 µM 0.0874555515585392 0.466171542758892 no 1542 0.46515470736129 2191 3523074 SGTC_2267 7931562 200 µM 0.0873408856694624 0.466214922645109 no 1543 0.465200278055055 2097 934880 SGTC_471 1-acyl-paf 4 µM 0.0870895921427817 0.466309992291017 no 1544 0.465300149109675 2210 16759367 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.087052231566309 0.466324126750053 no 1545 0.46531499743132 2219 17037758 SGTC_3155 9099265 49.47 µM 0.0836311243945949 0.467618596604112 no 1546 0.466674859962718 2206 25236499 SGTC_445 e6 berbamine 66 µM 0.0810160112295948 0.468608328194583 no 1547 0.467714609620787 2184 6610268 A calcium/calmodulin antagonist. SGTC_2146 5545642 200 µM 0.0810120428531369 0.468609830239405 no 1548 0.467716187587123 2243 825326 SGTC_2883 9059145 45.46 µM 0.0803666205853362 0.46885413082955 no 1549 0.467972836960325 2247 16476510 SGTC_1675 st018485 24.5 µM 0.0793916574087875 0.469223189080982 no 1550 0.468360552060364 2131 3323024 SGTC_1225 1216-0074 20.6 µM 0.0792059295743151 0.46929349668291 no 1551 0.468434414147175 2173 4241466 SGTC_1519 esterone 74 µM 0.0770056143161552 0.470126502199629 no 1552 0.469309539326963 2129 698 A steroid. SGTC_1547 harmine 94.2 µM 0.0757939007716538 0.470585294374399 no 1553 0.469791534323695 2264 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_506 n9-isopropylolomoucine 153 µM 0.0756797286161271 0.47062852550134 no 1554 0.469836951977472 2290 6610355 SGTC_1886 st057356 49.9 µM 0.0754534849637211 0.470714193365885 no 1555 0.469926952802311 2159 24207747 SGTC_3074 9116018 49.47 µM 0.0747325545234945 0.470987184946464 no 1556 0.470213752662226 2249 17027303 SGTC_275 trichlorophene 5.69 µM 0.0740359954400185 0.471250960883661 no 1557 0.470490871811433 2193 62616 SGTC_1157 4092-0394 27.6 µM 0.0736955765192291 0.471379876754403 no 1558 0.4706263093229 2253 3659885 SGTC_2276 7947513 42.08 µM 0.0736305734915303 0.4714044935945 no 1559 0.47065217151638 2020 2105100 SGTC_2918 7977171 22.06 µM 0.0733557571735881 0.471508568558423 no 1560 0.470761511678998 2292 2236483 SGTC_1327 1436-0082 2.18 µM 0.0720642521684018 0.471997696957913 no 1561 0.471275387433402 2140 15992205 SGTC_2699 st077704 54.6 µM 0.0718118395245871 0.472093297512319 no 1562 0.471375825285255 2210 645852 SGTC_1548 st061468 90.8 µM 0.0716241279527212 0.472164393766724 no 1563 0.471450519027984 2278 390799 SGTC_3270 9137563 49.47 µM 0.0714356591673324 0.472235777710058 no 1564 0.47152551508964 2253 17015724 SGTC_2033 5192550 145 µM 0.0712535120664312 0.472304768116213 no 1565 0.471597996567238 2233 182073 SGTC_191 3914-0123 66.505 µM 0.0712025499565069 0.472324070777402 no 1566 0.471618275999116 2193 3144412 SGTC_865 0488-0499 301 µM 0.0709114555278557 0.472434328389742 no 1567 0.471734113068105 2290 9634651 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0704852313063431 0.472595772817957 no 1568 0.471903727511415 2274 140250 A respiratory chain inhibitor. SGTC_1569 carminic acid 40.6 µM 0.0704455397480567 0.472610807343103 no 1569 0.47191952288852 2284 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1303 1160-0052 261 µM 0.0702098467535722 0.472700084869152 no 1570 0.472013318546017 2278 3562476 SGTC_1387 3342-1166 1.8 µM 0.0701277473690769 0.472731183400177 no 1571 0.472045990928737 2205 3418228 SGTC_2617 dihydrotanshinone i 20.83 µM 0.0695248710952414 0.472959552755865 no 1572 0.472285918138891 2250 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_850 0388-0143 75.9 µM 0.0687356362382522 0.473258528110744 no 1573 0.472600025827872 2170 67273 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0685094828791478 0.473344201567254 no 1574 0.47269003578384 2238 4174840 SGTC_3187 9109394 49.47 µM 0.0677511736245815 0.47363148009871 no 1575 0.47299185610043 2214 17098090 SGTC_3258 9138477 49.47 µM 0.0672169874571895 0.473833859888502 no 1576 0.473204480836767 2289 4970355 SGTC_1594 piperine 70.1 µM 0.0648997957138333 0.47471182006957 no 1577 0.474126891624815 2298 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1883 5-benzylidenerhodanine 20 µM 0.0630692861084917 0.475405468427331 no 1578 0.47485566586292 2298 1273210 SGTC_871 0574-0004 149 µM 0.0623741040834185 0.475668918469011 no 1579 0.475132458371521 2162 9551173 SGTC_3086 9117350 49.47 µM 0.0622668693343641 0.475709557695025 no 1580 0.475175155851112 2302 2679265 SGTC_945 3381-0768 11.3 µM 0.0620376743106076 0.475796417591139 no 1581 0.475266415003303 2283 1126236 YIL048W NEO1 SGTC_2303 7774051 200 µM 0.0615604168839546 0.475977291393409 no 1582 0.475456449937633 2274 2953184 SGTC_319 1348-1596 45.5 µM 0.0600267275054326 0.476558571264143 no 1583 0.476067173798116 2288 5380505 SGTC_1213 1315-0166 115 µM 0.0599420441183089 0.476590668372744 no 1584 0.476100896857153 2101 768401 SGTC_2971 9092186 9.93 µM 0.0599333342548016 0.476593969636122 no 1585 0.47610436535403 2114 25236400 SGTC_219 mitoxanthrone 164.414 µM 0.0599051071622487 0.476604668444775 no 1586 0.476115606137613 2271 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1807 st050092 58.9 µM 0.0585521241864585 0.477117504126043 no 1587 0.476654422289637 2252 5008496 SGTC_2179 6298986 200 µM 0.058509449125904 0.477133680333977 no 1588 0.476671418038194 2304 738374 SGTC_2563 tomatine 8.54 µM 0.0579353548925221 0.477351297448602 no 1589 0.476900060637246 2342 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1015 4130-4525 82 µM 0.05778078758845 0.477409889144566 no 1590 0.476961620945365 2218 1363237 SGTC_298 1391-0729 10 µM 0.0575535800221667 0.477496017408814 no 1591 0.477052113058679 2273 3237558 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0573870917188841 0.477559129304617 no 1592 0.477118422686476 2309 688801 SGTC_2231 micatex 6.853 µM 0.0572115487947313 0.477625674208964 no 1593 0.477188339311042 2241 20737 An antifungal of unknown mechanism. SGTC_722 3534-0461 190 µM 0.0562982026947773 0.477971915955721 no 1594 0.477552125303838 2251 658262 SGTC_1682 st012968 530 nM 0.0553809801689309 0.478319643955462 no 1595 0.47791747410318 2178 24207270 SGTC_2810 7959871 45.46 µM 0.054829810774215 0.478528605600875 no 1596 0.478137025277379 2269 2974535 SGTC_2414 st077232 92.9 µM 0.0536962867135297 0.47895837047005 no 1597 0.478588570654482 2136 729801 SGTC_1187 1391-0724 117 µM 0.05364639733628 0.478977286118787 no 1598 0.478608444990649 2210 6997986 SGTC_2180 6301957 200 µM 0.0535842657818133 0.479000843477632 no 1599 0.478633196293995 2305 845462 SGTC_1055 3448-0672 86 µM 0.0532194241328187 0.479139175723046 no 1600 0.478778539662816 2260 748378 SGTC_1697 st025554 27.742 µM 0.0531563445100676 0.479163093055414 no 1601 0.478803669221064 2297 1269519 SGTC_1369 1866-0067 208 µM 0.0523984148966893 0.479450476241943 no 1602 0.479105618556551 2288 3531355 SGTC_344 k064-0035 6.43 µM 0.0513725684472218 0.479839462093749 no 1603 0.479514321554586 2253 5088750 SGTC_1969 st069479 40.1 µM 0.0483960953275836 0.480968204173197 no 1604 0.480700285568834 2325 3895485 SGTC_2612 dictamnine 15.46 µM 0.0482954027978166 0.481006391647212 no 1605 0.480740409158189 2260 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1526 st051518 75 µM 0.0482201410983701 0.481034934635077 no 1606 0.480770399291148 2157 673993 SGTC_2800 7887935 81.82 µM 0.0467772425277797 0.481582172323774 no 1607 0.48134538350315 2264 2961002 SGTC_1854 st056233 32.9 µM 0.044413227630647 0.48247882966862 no 1608 0.482287508964507 2333 5393174 SGTC_154 3389-1638 511.116 µM 0.0442819185492046 0.48252863709315 no 1609 0.482339842221449 2112 5238686 SGTC_715 0868-0130 184 µM 0.0439783355409071 0.482643791540366 no 1610 0.48246083644503 2325 2876258 SGTC_1250 0485-0349 40.2 µM 0.0431470314319014 0.482959127391659 no 1611 0.482792164261631 2293 6842794 YDL195W SEC31 SGTC_1556 plumbagin 1.48 µM 0.0421626759981194 0.483332533467278 no 1612 0.483184508162469 2328 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2894 9048625 32.47 µM 0.0411386976043904 0.483720985653593 no 1613 0.48359266223784 2328 4092861 SGTC_2974 9094440 9.66 µM 0.040720070997614 0.483879798573476 no 1614 0.483759530261348 2278 25236134 SGTC_1753 st043925 64 µM 0.0403366366656937 0.484025262967029 no 1615 0.48391237285001 2312 670181 SGTC_2149 5554786 194.827 µM 0.0401235482762675 0.484106103735989 no 1616 0.48399731405305 2301 745063 YPR165W RHO1 SGTC_405 ebelactone b 50 µM 0.0398765693262846 0.48419980261105 no 1617 0.484095765605331 2245 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1583 clindamycin 39.6 µM 0.0395217463543827 0.484334416877435 no 1618 0.484237207987979 2214 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2936 9038235 15.59 µM 0.0389674019022467 0.484544730029872 no 1619 0.484458189188859 2335 4749415 SGTC_2852 9023854 51.95 µM 0.0387579953308407 0.484624178066197 no 1620 0.48454166726117 2323 19798528 SGTC_870 0573-2213 57.6 µM 0.0385870664061159 0.484689028286081 no 1621 0.484609807063308 2339 3916321 SGTC_593 1203-0218 61.7 µM 0.037745593245531 0.485008288020539 no 1622 0.484945261862744 2356 3666956 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0375174902763531 0.485094833257135 no 1623 0.485036197370052 2333 6710655 SGTC_1999 st074831 12.5 µM 0.0372990330507559 0.485177719431287 no 1624 0.485123288235783 2248 17112523 SGTC_3196 9111891 49.47 µM 0.0364767846878548 0.485489699356178 no 1625 0.48545109476153 2354 18891510 SGTC_1716 st033144 30.6155 µM 0.036207475007435 0.485591883578142 no 1626 0.485558462852606 2337 674617 SGTC_1711 st032263 62.8 µM 0.0357432465388065 0.485768028089295 no 1627 0.485743543407999 2273 3958979 SGTC_2447 5741742 33.78 µM 0.0344921348794326 0.486242757323552 no 1628 0.48624235703756 2309 1776504 SGTC_2227 7312221 64.1025 µM 0.0336470900463567 0.486563417223914 no 1629 0.486579285540594 2321 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1506 4226-2149 212 µM 0.0316897215040208 0.487306191427761 no 1630 0.487359745911494 2266 991114 SGTC_1310 1188-0297 994 nM 0.0296252661450127 0.488089650162979 no 1631 0.488182957342396 2327 1588352 SGTC_24 0417-1663 219 µM 0.0278256806938062 0.488772628636396 no 1632 0.488900591829134 2318 4329390 SGTC_3148 9097893 49.47 µM 0.0276282844755723 0.488847546467513 no 1633 0.488979311261453 2322 17174100 SGTC_27 0485-0001 32.618 µM 0.0274135455250277 0.488929046836519 no 1634 0.489064947271379 2355 2054479 SGTC_430 0958-0115 16.4 µM 0.0268045208961404 0.489160193861527 no 1635 0.489307823680599 2245 6833180 SGTC_2639 lactacystin 53 µM 0.0251265437240795 0.489797065903347 no 1636 0.489977014016545 2342 3870 A proteasome inhibitor. SGTC_3102 9121669 49.47 µM 0.0239886694182489 0.490228958153219 no 1637 0.490430823301062 2264 41905072 SGTC_777 1315-0167 517 µM 0.0238514962704578 0.490281024458803 no 1638 0.490485531815874 2244 4221767 SGTC_3314 9135860 59.4275 µM 0.0237273224123556 0.4903281568148 no 1639 0.490535056002217 2352 25252478 SGTC_1406 3909-7906 11.9 µM 0.0236020877452153 0.490375691956174 no 1640 0.490585003418188 2367 X1406 SGTC_186 3455-3465 67.277 µM 0.0231042609797097 0.490564652686209 no 1641 0.490783553412151 2375 755278 SGTC_1893 st059353 36.1 µM 0.019848322806592 0.491800563509487 no 1642 0.492082184719172 2317 3112488 SGTC_3341 9147222 25.867 µM 0.0195657516576777 0.491907827641828 no 1643 0.492194892409204 2342 1939759 SGTC_3315 9136395 68.55 µM 0.0181797246018188 0.492433972449805 no 1644 0.492747738694092 2375 16876844 SGTC_2151 5563267 85.4165 µM 0.0173243121014401 0.492758699178272 no 1645 0.493088945130139 2352 5310824 SGTC_1014 4130-3005 69.3 µM 0.0170753930662858 0.492853193288576 no 1646 0.493188234769645 2369 743608 SGTC_1820 st053765 18.6 µM 0.0167503936605827 0.492976569468821 no 1647 0.493317872230652 2350 3690829 SGTC_2718 lomofungin 53.02 µM 0.0155490820228975 0.493432616784261 no 1648 0.493797063712047 2362 5351222 A RNA synthesis inhibitor. SGTC_1788 fluconazole 20 µM 0.0140989694852365 0.493983126393701 no 1649 0.494375511303059 2307 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1228 0124-0032 52.5 µM 0.0139859677983125 0.494026025982838 no 1650 0.494420588009128 2365 X1228 SGTC_929 2805-0021 398 µM 0.0128144731368782 0.494470772346572 no 1651 0.494887904775155 2283 3098024 SGTC_1124 fisetin 1.16336 µM 0.012480044014734 0.494597736340941 no 1652 0.495021312021273 2346 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3132 9126706 49.47 µM 0.0121976213751898 0.494704956815325 no 1653 0.495133973776233 2354 850858 SGTC_953 1188-0045 9.7 µM 0.0121322934937238 0.494729758304035 no 1654 0.495160033901894 2372 6144426 SGTC_517 1365-0151 113 µM 0.011287005206 0.495050670680489 no 1655 0.495497232010555 2345 768657 SGTC_647 0140-0236 81 µM 0.0103143834790802 0.495419928948097 no 1656 0.495885229293397 2374 990837 SGTC_1604 st002052 72.4 µM 0.00990409719792368 0.495575696354494 no 1657 0.496048901473276 2337 6254834 YHR062C RPP1 SGTC_504 lovastatin 124 µM 0.00962248917681441 0.495682610755105 no 1658 0.496161241464667 2381 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2977 9011197 71.43 µM 0.00953546290015473 0.495715650936043 no 1659 0.496195958333131 2384 2704722 SGTC_3001 9076041 71.4286 µM 0.00932353249141698 0.49579611203329 no 1660 0.496280502574794 2391 16004211 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.00799530576210842 0.496300387839241 no 1661 0.496810368469614 2392 2374 Ca(2+)-ATPase inhibitor. SGTC_1777 st045864 34.765 µM 0.00789776589759047 0.496337420158508 no 1662 0.496849280016978 2390 4691462 SGTC_1336 1486-0901 104 µM 0.00760561798966373 0.496448338222091 no 1663 0.496965826667544 2351 5006114 SGTC_328 k915-0120 63.5 µM 0.00731904483567552 0.496557140018714 no 1664 0.497080149631546 2387 6624543 SGTC_3085 9117376 49.47 µM 0.00550998995247805 0.497243980421842 no 1665 0.497801843166045 2370 16480349 SGTC_673 1082-0474 110 µM 0.00540327547158556 0.497284496779556 no 1666 0.497844415450587 2387 3098046 SGTC_3277 9138724 49.47 µM 0.00531198557710876 0.497319156896565 no 1667 0.497880834326564 2377 15943418 SGTC_2376 9072922 81.32 µM 0.00415194375973682 0.497759592698621 no 1668 0.498343618847352 2385 17087968 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0038965757783077 0.497856549245538 no 1669 0.498445495106999 2397 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_70 0141-0289 43.283 µM 0.00227733451526575 0.498471335533452 no 1670 0.499091475760549 2388 352408 SGTC_533 1222-0222 6.71 µM 0.00130079596927369 0.498842105173652 no 1671 0.499481057636029 2402 3982874 SGTC_2517 totarol 10 µM 0.000993035574961463 0.498958955069988 no 1672 0.499603836188316 2401 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_39 0986-0283 58.349 µM 0.000951548969411402 0.498974706634574 no 1673 0.499620386941516 2401 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1514 1189-1591 158 µM 0.000356084636368037 0.499200791694642 no 1674 0.499857942786153 2403 767698 YMR146C TIF34 SGTC_173 1273-0061 2.693 µM -0.00138583875980253 0.499862163924704 no 1675 0.499447130501865 2411 2847414 YPL266W DIM1 SGTC_3325 9138760 55.175 µM -0.00161537442791115 0.499949313930591 no 1676 0.499355559122298 2410 43844959 SGTC_1597 7-benzyloxygramine 47.5 µM -0.00188236833962836 0.499949313930591 no 1677 0.499249044125512 2412 260807 SGTC_714 4296-0578 26.1 µM -0.00215141575015245 0.499847162123517 no 1678 0.499141709956655 2410 1589775 SGTC_2072 5231554 129 µM -0.002810136170487 0.499597059488782 no 1679 0.498878919343411 2411 789545 SGTC_2756 carbadox 75.1 µM -0.00299609597648321 0.499526454388468 no 1680 0.498804732427079 2417 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2751 anetholtrithion 17.25 µM -0.00319953290772839 0.499449213601476 no 1681 0.498723573223371 2415 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2996 9066192 71.4286 µM -0.00373596799656832 0.499245540421307 no 1682 0.49850956787505 2418 6472854 SGTC_887 0885-0007 9.62 µM -0.00538275398015244 0.498620291693934 no 1683 0.497852602222121 2427 5719458 SGTC_2337 9009472 200 µM -0.00579870499556387 0.498462364639391 no 1684 0.497686664370012 2414 5742383 SGTC_92 0063-0024 660.874 µM -0.0075085956588272 0.49781316119709 no 1685 0.497004531872202 2412 3594437 SGTC_3089 9117425 49.47 µM -0.00758402294335993 0.497784523432498 no 1686 0.496974441596098 2436 9401657 SGTC_2525 harmine 47.85 µM -0.00771894840132666 0.497733295798208 no 1687 0.496920615701901 2427 5280953 A monoamine oxidase inhibitor SGTC_1245 0418-0076 17.2 µM -0.00832050369584133 0.497504901600881 no 1688 0.496680637581879 2432 6790114 SGTC_2030 5175110 200 µM -0.00847537414660861 0.497446101628893 no 1689 0.49661885538979 2425 2831986 SGTC_2544 sphondin 68.51 µM -0.0088069887058982 0.497320197058007 no 1690 0.496486565261044 2423 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2458 5808907 16.39 µM -0.0093036045262602 0.497131646726958 no 1691 0.496288452337858 2428 2731747 SGTC_3186 9110464 49.47 µM -0.00952490127015983 0.497047627105819 no 1692 0.496200171622547 2434 17018021 SGTC_2032 5185112 25.99 µM -0.0096261362246483 0.497009191326056 no 1693 0.496159786570471 2420 5718189 SGTC_1307 1187-1599 12.2 µM -0.00999374482933148 0.496869621949637 no 1694 0.496013139012728 2426 1538471 SGTC_3337 9144342 33.5465 µM -0.010300560857884 0.496753133886892 no 1695 0.495890743428488 2438 17682949 SGTC_390 dec-rvkr-cmk 16.7 µM -0.010770364749219 0.49657476517591 no 1696 0.495703329195863 2432 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1821 st053465 65.6 µM -0.0107836396750786 0.496569725143541 no 1697 0.495698033574204 2432 675086 SGTC_2286 7945697 125 µM -0.0109967504433721 0.496488814396507 no 1698 0.4956130197198 2435 1245733 SGTC_735 3076-0345 636 µM -0.0119779997926704 0.496116270060169 no 1699 0.495221583710209 2434 2888990 SGTC_1909 st060837 51.5 µM -0.0127963927150504 0.495805558904024 no 1700 0.494895117228499 2439 678937 SGTC_1726 st035556 14.5795 µM -0.0131488858692525 0.495671732083323 no 1701 0.494754504638764 2545 5919439 SGTC_1087 pterostilbene 9.05 µM -0.01338807495414 0.495580922327343 no 1702 0.49465909039935 2429 5281727 Similar to reservatol, lowers cholesterol. SGTC_423 5-fluorouracil 457 µM -0.0142177026404356 0.495265950362142 no 1703 0.494328148374781 2427 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_783 0848-0141 92.7 µM -0.0167345839084315 0.494310423689334 no 1704 0.493324178525304 2433 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1102 cgs 12066b 26.1 µM -0.0170102269692344 0.494205778485247 no 1705 0.493214228505692 2470 6438352 A 5-HT1B full agonist. SGTC_1710 st031758 61.5 µM -0.0173848790896171 0.494063546096402 no 1706 0.493064786036178 2452 5394341 SGTC_1830 st055982 50.3 µM -0.019094528836524 0.493414506992587 no 1707 0.492382847995825 2434 455313 An antimicrobial agent. SGTC_2635 hydroquinidine 100 µM -0.019400197291949 0.493298467011479 no 1708 0.492260926511314 2450 442912 An experimental heart treatment. SGTC_1144 3486-0183 12.5 µM -0.0194375957653986 0.493284269582093 no 1709 0.492246009491854 2459 6744069 SGTC_68 0986-0284 82.829 µM -0.0204925509737591 0.492883784826525 no 1710 0.491825227145971 2566 423278 YIL048W NEO1 SGTC_732 3970-1727 52.7 µM -0.0206055014511281 0.492840906699549 no 1711 0.491780175937703 2449 1275699 SGTC_2811 7967822 32.47 µM -0.0210720970528221 0.492663779109784 no 1712 0.491594071638826 2469 2232244 SGTC_3328 9140624 29.0385 µM -0.0231750678167074 0.491865474263032 no 1713 0.490755313132695 2452 4904392 SGTC_1233 0325-0408 14.2 µM -0.0241757530297504 0.491485617241857 no 1714 0.49035620937799 2460 12874 SGTC_1470 k295-0292 231 µM -0.0242113575252903 0.491472102025352 no 1715 0.49034200939578 2521 5045612 SGTC_2139 5578692 56.4705 µM -0.0244062909354514 0.491398106845551 no 1716 0.490264265190383 2453 650991 YMR113W FOL3 SGTC_2534 helenine 20.12 µM -0.0244158080822643 0.491394494219497 no 1717 0.490260469529215 2455 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1653 st012112 65 µM -0.0247161550208923 0.491280485501256 no 1718 0.490140684586865 2462 720429 SGTC_1921 5740136 50 µM -0.0250978515253937 0.491135598323939 no 1719 0.489988456939067 2455 1774243 SGTC_1903 st060211 78.3 µM -0.0263775650513326 0.490649843858729 no 1720 0.489478094209276 2450 688960 SGTC_527 4476-4215 268 µM -0.0280021487437022 0.490033203427898 no 1721 0.48883021868523 2486 4418754 SGTC_2790 5423970 71.43 µM -0.0282838906743051 0.489926265511616 no 1722 0.488717864420083 2485 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2854 9024559 71.43 µM -0.0292125364717462 0.489573794049064 no 1723 0.488347541421423 2475 3163529 SGTC_2991 9074669 71.4286 µM -0.0293098293252938 0.489536866599108 no 1724 0.48830874380172 2482 17333109 SGTC_2794 7785382 27.27 µM -0.0294168285706433 0.489496255196962 no 1725 0.488266075677102 2436 2205081 SGTC_694 1315-0438 43.2 µM -0.0311931374412929 0.488822076074616 no 1726 0.487557756390699 2487 6793154 SGTC_1120 ficusin 1.78878 µM -0.0320705561257425 0.488489072817636 no 1727 0.487207892067391 2542 6199 A DNA cross-linker. SGTC_1492 4158-0558 28.5 µM -0.0325216647406223 0.488317868450799 no 1728 0.487028019600828 2485 3967268 SGTC_1906 st060206 94.7 µM -0.0338676388660853 0.487807058385976 no 1729 0.4864913494102 2458 5133468 SGTC_1751 st044839 27.194 µM -0.0354861705331561 0.487192836686817 no 1730 0.485846036873293 2462 5291326 SGTC_1632 st005650 90 µM -0.0367448823713583 0.486715185076096 no 1731 0.48534421091568 2517 2759605 SGTC_183 3914-0051 30.55 µM -0.036779511978892 0.486702044218744 no 1732 0.485330405033277 2471 1596232 SGTC_941 3237-0776 460 µM -0.0368435464761893 0.486677745159729 no 1733 0.485304876267637 2490 760008 SGTC_2349 9023730 187.07 µM -0.0375159377770879 0.48642259700907 no 1734 0.485036816291929 2490 4126287 SGTC_2441 5730946 39.09 µM -0.0377603514123844 0.486329852256798 no 1735 0.48493937840031 2522 1774275 SGTC_2866 9034245 58.44 µM -0.0383652208454007 0.486100332794622 no 1736 0.484698245150307 2558 6462273 SGTC_2103 5378138 10 µM -0.0383998419791078 0.486087195843528 no 1737 0.484684443486456 2469 244142 SGTC_3162 9099653 49.47 µM -0.0384810543128576 0.486056379972113 no 1738 0.48465206838151 2479 25237511 SGTC_3301 9125354 19.7965 µM -0.0398818185202908 0.485524875817405 no 1739 0.484093673144438 2487 41905162 SGTC_2591 skatole 100 µM -0.0403614688189721 0.485342883792531 no 1740 0.48390247431507 2508 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1478 0453-0656 35.7 µM -0.0415587884631064 0.484888602418012 no 1741 0.483425213440278 2489 5258496 SGTC_2065 5221596 34.26 µM -0.042196550899839 0.484646633569224 no 1742 0.483171006048213 2529 788581 SGTC_2689 tacrolimus 100 µM -0.0423811621425842 0.484576592599574 no 1743 0.483097422643918 2521 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_98 0074-0023 107.663 µM -0.0442968924888143 0.483849798556422 no 1744 0.482333874339859 2528 3563821 SGTC_376 3970-0862 59.1 µM -0.0451383641171495 0.48353057599472 no 1745 0.481998511214291 2519 3135186 SGTC_680 0417-1641 114 µM -0.0454413268910845 0.483415645932148 no 1746 0.481877770448287 2483 2835990 SGTC_3175 9106517 49.47 µM -0.0455735796693722 0.483365475777052 no 1747 0.481825063827448 2526 41468073 SGTC_1077 5-fluorocytosine 377 nM -0.0457316755986051 0.483305502355882 no 1748 0.48176205836801 2530 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2347 9049783 174.81 µM -0.0463085476465096 0.483086670142041 no 1749 0.481532163291563 2527 6467988 YPL169C MEX67 SGTC_2122 5258151 111.688 µM -0.046346661042847 0.483072212281175 no 1750 0.481516974554455 2517 2173356 SGTC_3295 9122362 53.5725 µM -0.0467846887436632 0.48290605331668 no 1751 0.481342416141557 2528 4730473 SGTC_1424 4048-1941 275 µM -0.0476612706361822 0.482573544616072 no 1752 0.480993100279689 2551 X1424 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.047891351828791 0.482486271257005 no 1753 0.48090141586229 2539 688751 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0485810384580638 0.482224667483892 no 1754 0.480626590619275 2485 1377 SGTC_2641 levomentholum 100 µM -0.0490657860718986 0.482040803326916 no 1755 0.480433434655336 2485 16666 SGTC_3009 9080819 71.4286 µM -0.050160667846515 0.481625530171794 no 1756 0.479997177293405 2543 17027216 SGTC_1982 st072467 71.9 µM -0.0503124147092033 0.481567976298177 no 1757 0.479936715396324 2486 3163533 SGTC_2243 6634756 200 µM -0.0520045467706702 0.480926218294178 no 1758 0.479262535259609 2555 885676 SGTC_2205 7238770 200 µM -0.0521850692238614 0.480857756237521 no 1759 0.479190614878057 2537 279867 SGTC_359 0081-0058 15.9 µM -0.0549601531370537 0.479805394588666 no 1760 0.478085104487505 2592 3494159 SGTC_1434 4073-0095 163 µM -0.0574584207748929 0.478858126818971 no 1761 0.477090013386878 2506 24133745 SGTC_2861 9024595 19.48 µM -0.0585169249232275 0.478456809662469 no 1762 0.476668440727774 2487 16482810 SGTC_169 k015-0017 16.025 µM -0.0592679694074712 0.478172074793123 no 1763 0.476369336480246 2532 1840002 SGTC_3312 9133330 71.43 µM -0.0609591790168787 0.477530946929269 no 1764 0.475695859494423 2643 17617324 SGTC_1116 jasmonic acid  1.58368 µM -0.0610068378688604 0.477512880566439 no 1765 0.47567688168471 2606 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1417 3966-0327 90.4 µM -0.061013690600208 0.477510282859094 no 1766 0.475674152923737 2528 651118 SGTC_2340 7987427 183.45 µM -0.0611866010532107 0.47744473693853 no 1767 0.475605300274733 2577 2239331 SGTC_2397 5161689 200 µM -0.061314598363039 0.477396216832208 no 1768 0.475554332432222 2566 2259942 SGTC_1266 0828-0227 32.9 µM -0.0633429267718033 0.476627380949708 no 1769 0.474746716876775 2579 3913820 SGTC_2892 9047358 58.44 µM -0.0654565057074588 0.475826323539367 no 1770 0.473905267723972 2560 6466771 SGTC_2845 9003024 42.97 µM -0.06594155666135 0.4756425003703 no 1771 0.473712177565789 2632 2990173 SGTC_1344 1488-0097 29.1 µM -0.0660858232256845 0.475587827654964 no 1772 0.473654748801844 2592 747966 SGTC_1499 4480-0877 67.3 µM -0.0663948377558754 0.475470721933339 no 1773 0.473531740005082 2519 2861909 SGTC_1096 rimcazole 32.2 µM -0.0683894241089391 0.474714894740329 no 1774 0.472737820229264 2511 18528119 A dopamine reuptake inhibitor. SGTC_2203 7227154 166.4 µM -0.0687704526268267 0.474570518321701 no 1775 0.4725861688879 2535 896304 SGTC_3140 9094243 49.47 µM -0.0693023901946835 0.474368966186839 no 1776 0.472374461606992 2531 19291112 SGTC_1289 0976-0073 69.1 µM -0.0700458899580834 0.474087263745997 no 1777 0.472078567202631 2626 3391136 SGTC_1955 wogonin 32.4 µM -0.070190173454062 0.47403259809286 no 1778 0.4720211477419 2752 5281703 A flavanone. SGTC_3253 9135987 49.47 µM -0.0703788826789888 0.473961101304771 no 1779 0.471946049372527 2552 4182430 SGTC_2353 9059630 146.67 µM -0.0712899409091094 0.473615937983112 no 1780 0.47158350042619 2594 4779114 SGTC_719 2810-4230 27.3 µM -0.0714705601436938 0.47354751096384 no 1781 0.471511627112692 2531 721079 SGTC_2306 7482397 179.52 µM -0.0715141362970981 0.4735310023943 no 1782 0.471494287113075 2568 891448 SGTC_2035 5154463 94.595 µM -0.0721789008143861 0.473279165917926 no 1783 0.471229768040703 2558 2769623 SGTC_1559 coumarin 343 70.1 µM -0.072279623109929 0.473241009654064 no 1784 0.471189690338934 2598 108770 A hepatotoxic, DNA x-linker. SGTC_1530 rhein 70.4 µM -0.073998215078205 0.472589999780543 no 1785 0.470505902764905 2527 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3002 9075603 71.4286 µM -0.0747896104875076 0.472290240381788 no 1786 0.470191054148043 2536 20105405 SGTC_3206 9114350 49.47 µM -0.076130176796361 0.471782505642973 no 1787 0.469657766094269 2537 17087243 SGTC_1975 st070967 30.8 µM -0.0772291422096081 0.471366310553612 no 1788 0.469220629370816 2553 261391 SGTC_1731 st035964 63 µM -0.077635962034785 0.471212249540381 no 1789 0.46905881756664 2609 6739575 SGTC_1814 st052110 31.539 µM -0.0782288424346439 0.470987735864405 no 1790 0.468823009684527 2564 674163 SGTC_587 k089-0003 57 µM -0.0785915811412198 0.470850377456862 no 1791 0.468678742051226 2538 9659696 SGTC_1634 st006576 41 µM -0.0791811008680042 0.470627151196844 no 1792 0.468444288355685 2570 3915356 SGTC_1305 1181-0477 144 µM -0.0795130762227234 0.470501450187226 no 1793 0.468312265611076 2623 6252086 SGTC_3072 9116419 49.47 µM -0.0797483192487033 0.470412378227524 no 1794 0.468218714299434 2596 17170162 SGTC_1618 st003135 44.5 µM -0.0800433753880184 0.470300660840765 no 1795 0.468101379024916 2531 1270615 SGTC_2427 5545055 42.75 µM -0.0802987659625116 0.470203963951566 no 1796 0.467999819832822 2560 5372858 SGTC_2472 5377652 49.4 µM -0.0804510780272742 0.470146295850992 no 1797 0.467939252064504 2586 1610903 SGTC_2497 7-hydroxyflavone 100 µM -0.0805999025840387 0.470089948788765 no 1798 0.46788007184066 2686 5281894 SGTC_1202 1988-0068 29.6 µM -0.0807502644479705 0.470033020288738 no 1799 0.467820281026106 2565 2850480 SGTC_41 0478-0632 82.643 µM -0.0819854873421304 0.469565375881577 no 1800 0.467329127012517 2533 3750424 SGTC_2237 6667747 47.222 µM -0.0825381061854355 0.469356172853065 no 1801 0.467109408670222 2617 729940 YDL015C TSC13 SGTC_817 1391-0715 46 µM -0.0830598757234233 0.469158656104207 no 1802 0.466901965046186 2613 1353946 SGTC_1735 st034310 56.75 µM -0.0847593329298624 0.468515376551912 no 1803 0.466226362384147 2783 871153 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0851488894465272 0.468367932906586 no 1804 0.466071511623998 2658 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1439 4092-1168 46 µM -0.0855169606238745 0.468228625255482 no 1805 0.465925206117851 2560 2886240 SGTC_3164 9100705 49.47 µM -0.0873919396614834 0.467519043568703 no 1806 0.465179988042726 2676 17174235 SGTC_76 0433-0009 400.328 µM -0.0874198640685218 0.467508476412721 no 1807 0.465168890289436 2715 2841569 SGTC_753 1322-0200 289 µM -0.0875686660478319 0.467452167144028 no 1808 0.465109753674963 2672 5403907 SGTC_2568 diosmetin 100 µM -0.0879469679089112 0.467309014045823 no 1809 0.464959413103802 2549 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_896 0964-0007 44.5 µM -0.0884202896555016 0.46712991045676 no 1810 0.464771317819857 2540 6756758 SGTC_859 0439-0102 54.6 µM -0.0885889080736387 0.467066107337584 no 1811 0.464704311749687 2553 610143 SGTC_1066 ketoconazole 628 nM -0.0886723746377759 0.467034524937401 no 1812 0.464671143937494 2664 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2290 7904846 200 µM -0.0891854613829334 0.466840385764256 no 1813 0.464467259733657 2622 2962154 SGTC_944 3370-0224 231 µM -0.0897448774114114 0.466628725741554 no 1814 0.464244976392648 2584 4580514 SGTC_83 0170-0301 39.027 µM -0.0897708421446697 0.466618901982839 no 1815 0.464234659605031 2557 3089716 SGTC_841 0251-0215 91.2 µM -0.0899521513772346 0.466550304188661 no 1816 0.464162619140981 2631 3888614 SGTC_536 3852-0578 10.6 µM -0.0916182328655579 0.465919994124103 no 1817 0.463500682322763 2709 2869208 SGTC_1433 4060-0023 7.6 µM -0.0916869884864122 0.465893984401076 no 1818 0.463473367763751 2650 3840627 SGTC_1219 1469-0211 33.1 µM -0.0926828234929604 0.465517284061349 no 1819 0.463077771567262 2560 6822282 SGTC_2302 7771753 200 µM -0.0927094819297414 0.46550720024147 no 1820 0.463067181983478 2627 2203047 SGTC_1413 3910-0535 34.4 µM -0.0929428520625679 0.465418926604964 no 1821 0.462974481020377 2678 2876951 SGTC_592 k241-0073 46.5 µM -0.0940009088853837 0.465018731747588 no 1822 0.462554217374306 2588 4230158 SGTC_3210 9128157 49.47 µM -0.0952443253474779 0.464548472507879 no 1823 0.462060381726815 2724 17590849 SGTC_51 1013-0126 23.419 µM -0.0964233849879418 0.464102598699894 no 1824 0.461592160060199 2577 1627850 SGTC_12 0849-0099 9.267 µM -0.0969332112997637 0.463909816443828 no 1825 0.46138971709125 2550 6071388 SGTC_3343 9148379 18.9835 µM -0.0993408180807273 0.462999535626719 no 1826 0.460433835270523 2659 1955036 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.100405168190233 0.462597181922675 no 1827 0.460011333440269 2682 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1676 st018489 23.4 µM -0.100586188224704 0.462528755151985 no 1828 0.459939480647041 2639 3696235 SGTC_1968 st069590 43.6 µM -0.100923882866558 0.462401107308505 no 1829 0.459805442058299 2650 6384066 SGTC_1923 st058458 19.1 µM -0.101411996521141 0.462216608250676 no 1830 0.459611706862133 2652 3534982 SGTC_2739 tacrine 100.86 µM -0.101845373163925 0.462052805708767 no 1831 0.4594397051452 2671 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2087 5276107 200 µM -0.102625102503137 0.461758109124879 no 1832 0.459130259554809 2588 144405 SGTC_193 1273-0060 1.558 µM -0.102739032762211 0.4617150512473 no 1833 0.459085046938877 2574 2847393 YHR072W ERG7 SGTC_1770 st043884 66.3 µM -0.102753218322215 0.46170969010327 no 1834 0.459079417512052 2590 670149 SGTC_166 k072-0058 166.424 µM -0.102829659334033 0.461680800896586 no 1835 0.459049082644881 2575 5846229 SGTC_2588 indole-3-carbinol 100 µM -0.103058882458355 0.461594172248533 no 1836 0.458958119122392 2683 3712 Induces cell cycle arrest. SGTC_3028 9087778 49.47 µM -0.104044615510078 0.46122166205763 no 1837 0.458566971310643 2608 17217395 SGTC_2959 9079155 11 µM -0.104770152339408 0.460947502177869 no 1838 0.458279097326508 2728 16189457 SGTC_3071 9117417 49.47 µM -0.105156492424942 0.460801522733956 no 1839 0.45812581663229 2678 45595590 YGL055W OLE1 SGTC_1006 4099-6547 255 µM -0.105421094875638 0.460701545167495 no 1840 0.458020839019867 2674 3146833 SGTC_2791 5663188 71.43 µM -0.106990338807608 0.460108672256502 no 1841 0.457398322137302 2699 54690634 SGTC_435 c-PAF 6.7 µM -0.107107281818932 0.460064493785648 no 1842 0.457351935173102 2597 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2335 9018011 154.17 µM -0.108219838326479 0.459644219395196 no 1843 0.456910654331942 2698 6458208 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.108591948222852 0.459503662857642 no 1844 0.456763073686777 2676 688798 SGTC_2704 st078022 71.1 µM -0.109098967827209 0.459312155219619 no 1845 0.456561996779216 2688 54697681 SGTC_1148 3909-7663 27.7 µM -0.110076893032375 0.458942807358139 no 1846 0.456174196733787 2753 4084526 SGTC_2411 st077133 39.94 µM -0.110390908197289 0.458824215984172 no 1847 0.456049681634625 2902 1403142 YNL221C POP1 SGTC_2626 ethyl orsellinate 100 µM -0.111136414817619 0.45854268168448 no 1848 0.455754086371563 2617 75653 A natural product. SGTC_2310 7668677 200 µM -0.111275832691255 0.458490034001893 no 1849 0.455698809544876 2725 2197143 SGTC_792 4534-1957 155 µM -0.111513879793771 0.458400143134624 no 1850 0.455604429881341 2673 1717904 SGTC_992 3909-8734 162 µM -0.112213664651549 0.458135904122822 no 1851 0.455326997387918 2644 4288319 SGTC_826 1683-5028 118 µM -0.113059365009008 0.457816592066252 no 1852 0.45499174519791 2677 722377 SGTC_188 3229-0966 278.469 µM -0.114159349566791 0.457401310396655 no 1853 0.454555737763628 2639 5722370 SGTC_2692 st077426 47.7 µM -0.114392850072036 0.457313161964677 no 1854 0.454463190803574 2655 25238571 SGTC_3137 9097352 49.47 µM -0.114560490808666 0.457249877451803 no 1855 0.454396748614737 2826 44120435 SGTC_1575 cyproterone acetate 48 µM -0.11466031891466 0.457212192776385 no 1856 0.454357183671247 2639 9880 An androgen receptor antagonist and liver toxin. SGTC_3032 9089427 49.47 µM -0.11467166907366 0.457207908165127 no 1857 0.454352685283409 2705 17173707 SGTC_2661 dactinomycin 12.96 µM -0.115677532348979 0.456828221125789 no 1858 0.453954056640861 2619 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2128 5255449 168.493 µM -0.115886456220528 0.456749362768104 no 1859 0.45387126487051 2633 736008 SGTC_2570 licareol 100 µM -0.116410776628459 0.456551465431531 no 1860 0.453663497474006 2732 443158 SGTC_2244 6635614 200 µM -0.117366578164699 0.456190739395127 no 1861 0.45328478387604 2597 836499 SGTC_324 1315-0088 19.6 µM -0.117919585556944 0.45598204709219 no 1862 0.453065687243748 2640 6787421 SGTC_2233 sulbentine 40.3845 µM -0.118157071876101 0.455892428927517 no 1863 0.452971601648167 2612 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3244 9134489 49.47 µM -0.118524922036139 0.455753620915667 no 1864 0.45282587467169 2691 16584271 SGTC_463 ikarugamyin 104 µM -0.118546225489608 0.45574558223703 no 1865 0.45281743532145 2613 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2763 lisinopril 49.32 µM -0.118886074062933 0.455617345693843 no 1866 0.45268280739867 2596 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.120487821036265 0.455013014000524 no 1867 0.452048363382905 2612 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2235 salicylic acid 500 µM -0.122108732551665 0.454401557593103 no 1868 0.451406453029965 2623 338 A COX inhibitor and kinase inhibitor. SGTC_3228 9131799 49.47 µM -0.12226870398394 0.454341217408105 no 1869 0.451343108302458 2664 17015818 SGTC_888 0916-0002 6.97 µM -0.122471603142143 0.454264686679721 no 1870 0.451262767040554 2788 2802138 YIL048W NEO1 SGTC_1009 4106-0057 9.87 µM -0.12248995208998 0.45425776579657 no 1871 0.451255501570975 2608 2928005 SGTC_1074 carmofur 3.8 µM -0.122624195399446 0.454207132130147 no 1872 0.451202346939342 2611 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1743 st037606 46.3785 µM -0.122919159746917 0.454095880587161 no 1873 0.451085556698342 2661 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2018 5133068 143 µM -0.123790669747867 0.453767194706194 no 1874 0.450740509726308 2625 785362 SGTC_90 0870-0863 4.608 µM -0.125700837344014 0.453046895082275 no 1875 0.449984369510611 2610 1738164 SGTC_341 1486-1430 230 µM -0.12662899597016 0.452696954020338 no 1876 0.449617023104072 2620 2054753 YPL210C SRP72 SGTC_110 0850-0284 111.64 µM -0.126687825988297 0.452674774737658 no 1877 0.449593740824745 2599 3906265 SGTC_532 1548-0774 215 µM -0.126932861012057 0.452582396599016 no 1878 0.449496768833459 2835 5932993 SGTC_1101 ebselen 5.29 µM -0.129478633005231 0.451622794003993 no 1879 0.448489465507702 2652 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2717 st081029 62.2815 µM -0.130440862604389 0.451260164734565 no 1880 0.448108819529688 2661 5292846 SGTC_489 paxilline 115 µM -0.130906446339717 0.451084717773875 no 1881 0.447924657563945 2695 105008 A toxic potassium channel blocker. SGTC_3287 9117173 37.0625 µM -0.132482778203266 0.450490776256764 no 1882 0.447301221976862 2638 2789709 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.13506026663418 0.449519851277453 no 1883 0.446282112449875 2629 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1262 0737-0114 49.6 µM -0.137948021449308 0.448432409894692 no 1884 0.44514074877363 2664 765919 SGTC_589 1227-0070 34.1 µM -0.138037887791055 0.448398575112798 no 1885 0.445105237013478 2748 2841384 SGTC_13 0199-0087 65 µM -0.138923640228337 0.448065108413053 no 1886 0.444755244953261 2647 4589825 SGTC_1237 0330-0133 46.1 µM -0.140476663418884 0.447480517376996 no 1887 0.444141694770787 2672 X1237 YHR072W ERG7 SGTC_1335 1486-0900 202 µM -0.140525543533042 0.447462119705036 no 1888 0.44412238595367 2636 X1335 SGTC_2862 9027634 71.43 µM -0.140830258264171 0.447347432636437 no 1889 0.444002019320869 2631 5012562 SGTC_791 1348-1292 225 µM -0.141142033095464 0.447230092877801 no 1890 0.443878869194725 2729 5437054 SGTC_206 4546-0025 72.014 µM -0.142496910505695 0.446720224200899 no 1891 0.443343759764946 2678 6620745 YIL048W NEO1 SGTC_808 0711-0032 135 µM -0.142730413649089 0.446632360962262 no 1892 0.443251548004567 2623 4252555 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.142954592888622 0.446548008614087 no 1893 0.443163021199989 2692 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2594 a-mangostin 100 µM -0.144078212139317 0.446125258780677 no 1894 0.442719354695356 2798 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2690 usnic acid 100 µM -0.144804149345703 0.445852165131028 no 1895 0.442432753027036 2812 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_503 tyrphostin 8 294 µM -0.14648221078683 0.445220986025 no 1896 0.441770366087461 2693 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2827 7993847 71.43 µM -0.146497714088806 0.445215155321792 no 1897 0.441764247172148 2754 2985692 SGTC_2292 7671323 168.05 µM -0.147674198147679 0.444772721060729 no 1898 0.441299947620403 2802 937504 SGTC_1453 4237-0541 195 µM -0.147724115854773 0.444753950284916 no 1899 0.441280249371619 2677 739892 SGTC_540 1187-0821 17.3 µM -0.148006627958246 0.444647718347094 no 1900 0.441168768750601 2676 847520 SGTC_1429 4049-0205 9.46 µM -0.148210660300685 0.444570999323509 no 1901 0.441088259515266 2653 22774478 SGTC_2529 gangaleoidin 93.61 µM -0.148226118053254 0.444565187076235 no 1902 0.441082160131261 2686 4565183 SGTC_3291 9121177 71.43 µM -0.148526975176271 0.444452064598087 no 1903 0.440963449466846 2699 17015612 SGTC_3316 9136639 10.545 µM -0.149919973757941 0.443928355322171 no 1904 0.440413876517621 2765 4903665 SGTC_2316 5844804 197.44 µM -0.151038456624205 0.44350792330562 no 1905 0.439972689932683 2788 776813 SGTC_609 0986-0026 86.3 µM -0.151346931277193 0.443391980419903 no 1906 0.439851024913309 2680 2848610 SGTC_579 4491-1009 110 µM -0.152692802008809 0.442886180005141 no 1907 0.439320268682677 2674 1271041 SGTC_1208 2323-2347 50.3 µM -0.153923319908908 0.442423812505862 no 1908 0.438835098296402 2775 5412760 SGTC_2281 7943571 200 µM -0.154366112118778 0.442257452342406 no 1909 0.438660535983852 2773 1244024 SGTC_1659 st012954 42.1 µM -0.154901307582746 0.442056389217426 no 1910 0.438449561394541 2806 24207262 SGTC_2961 9083290 32.55 µM -0.156690805987773 0.441384216155076 no 1911 0.437744266666184 2665 17741490 SGTC_3199 9111318 49.47 µM -0.158189474496745 0.440821414680181 no 1912 0.437153748730528 2798 8548020 SGTC_1525 8-methoxypsoralen 92.5 µM -0.158751214613497 0.440610492712681 no 1913 0.436932443176027 2890 4114 Related to psoralen; DNA damaging agent. SGTC_676 falcarinol 140 µM -0.159668029469784 0.440266283631536 no 1914 0.436571293267535 2778 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_443 clozapine 122 µM -0.161538484609215 0.439564179979184 no 1915 0.43583465150998 2652 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_604 1000-0114 314 µM -0.163104905432768 0.438976346337132 no 1916 0.435217918771901 2810 1572745 SGTC_335 4077-0256 27.6 µM -0.163299221440085 0.438903434364829 no 1917 0.43514142343786 2792 3121989 SGTC_2595 hexamethylquercetagetin 100 µM -0.166025052280821 0.437880857644623 no 1918 0.434068617451315 2794 386331 SGTC_2920 7982904 15.77 µM -0.166126403037558 0.437842844558274 no 1919 0.434028738117821 2806 6456808 SGTC_748 act1.228 77.9 µM -0.166854034215071 0.437569952686152 no 1920 0.433742450705492 2700 4421505 YNR035C ARC35 SGTC_480 am 92016 50 µM -0.166854833942662 0.437569652771446 no 1921 0.433742136070748 2755 2129 K+ channel blocker. SGTC_879 0831-1030 162 µM -0.170336863535596 0.43626416066965 no 1922 0.432372610972675 2732 1549252 SGTC_32 0928-0142 34.1 µM -0.170587174762791 0.436170339866321 no 1923 0.432274191579805 2713 2244242 SGTC_3344 9148862 3.898 µM -0.171263164382333 0.435916985695213 no 1924 0.43200842152967 2854 4905352 SGTC_2372 9071633 200 µM -0.171420782185186 0.435857915890364 no 1925 0.43194645740624 2703 21321366 SGTC_2978 9011784 42.97 µM -0.171436051523248 0.435852193536517 no 1926 0.431940454676124 2857 2994934 SGTC_1841 st054148 70 µM -0.17193297874528 0.435665971883784 no 1927 0.431745109671204 2788 675442 SGTC_1769 st044406 64.4 µM -0.171936116165616 0.435664796192298 no 1928 0.431743876385841 2715 670903 SGTC_874 0599-0792 117 µM -0.172004660818341 0.435639110466219 no 1929 0.431716932404196 2769 765305 SGTC_1658 st012944 20 µM -0.17236336374207 0.435504698211047 no 1930 0.431575936290161 2769 24207260 SGTC_2364 9055074 200 µM -0.173745716359875 0.434986776341626 no 1931 0.431032653718276 2804 6470630 SGTC_1462 k081-0014 26.5 µM -0.174168992804047 0.434828210900297 no 1932 0.43086632661072 2744 3270634 SGTC_245 methotrexate 289.6 µM -0.174831947397421 0.434579879652346 no 1933 0.430605842270978 2778 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2255 7941087 197.44 µM -0.174864946433189 0.434567519461587 no 1934 0.430592877265793 2860 935561 SGTC_54 0159-0055 9 µM -0.175298723280862 0.434405049010489 no 1935 0.430422457456263 2930 3319099 SGTC_3304 9125678 46.087 µM -0.175969447990148 0.434153851919762 no 1936 0.43015897242314 2746 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1613 st002381 52.1 µM -0.176770829529061 0.433853756631545 no 1937 0.429844201423291 2721 551167 SGTC_1834 st055981 52.8 µM -0.177281995870539 0.433662358834831 no 1938 0.429643446005629 2883 471719 YDL150W RPC53 SGTC_1629 st005085 44.9 µM -0.178817247490548 0.433087602904481 no 1939 0.429040601011275 2727 24207091 SGTC_2592 piperlongumine 83.33 µM -0.178975440126917 0.43302838795874 no 1940 0.428978493121972 2795 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2355 9061122 103.12 µM -0.179149855175162 0.432963102354205 no 1941 0.428910018202218 2850 5302957 SGTC_361 000s-0510 1.45 µM -0.181001486519084 0.432270128119488 no 1942 0.428183204606957 2814 660 SGTC_484 loperamide 105 µM -0.181184296699984 0.432201722554119 no 1943 0.42811146001349 2691 3955 An opioid-receptor agonist. SGTC_3214 9129694 49.47 µM -0.181394533088726 0.432123056915233 no 1944 0.428028954831996 2827 17158655 SGTC_928 2764-0428 58.7 µM -0.183087002717402 0.431489871857533 no 1945 0.427364876865081 2854 662578 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.185025327849981 0.430764923875241 no 1946 0.426604584899298 2714 803109 SGTC_962 1254-0300 21.5 µM -0.185739282945431 0.430497958019843 no 1947 0.426324610486664 2729 7340576 SGTC_1494 4358-1428 177 µM -0.186174061337288 0.430335398943058 no 1948 0.42615413219372 2858 1564571 SGTC_761 k216-0224 480 µM -0.187363380500689 0.429890785389432 no 1949 0.425687866130114 2809 1340404 SGTC_38 0929-0051 58.268 µM -0.187709180433736 0.429761528640944 no 1950 0.425552316626575 2856 1379719 SGTC_2829 7992743 58.44 µM -0.188679633069144 0.429398822866476 no 1951 0.425171957658869 2936 16462845 SGTC_2438 5259590 200 µM -0.189518424986341 0.429085373165939 no 1952 0.424843257856319 2867 1201127 SGTC_767 0929-0023 86 µM -0.193200484126936 0.427709949205298 no 1953 0.423400979800288 2765 1204563 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.194126043783336 0.427364346155625 no 1954 0.423038594760987 2796 676296 Flavone; oxidizing agent. SGTC_1223 0764-0573 147 µM -0.194713696271519 0.427144946214654 no 1955 0.422808544530911 2744 1609797 SGTC_626 0214-0009 33 µM -0.195101733641268 0.427000084886924 no 1956 0.422656652704239 2857 3437874 SGTC_636 0kpi-0074 126 µM -0.195338740147369 0.426911610937683 no 1957 0.422563885461778 2835 616434 SGTC_3064 1327-0027 10 µM -0.195435118145106 0.426875634318093 no 1958 0.422526163163845 2757 16000455 YPR107C YTH1 SGTC_1652 st011932 78 µM -0.197051299415364 0.42627242628723 no 1959 0.421893696781571 2839 1551076 SGTC_580 1123-0028 41 µM -0.198030333016506 0.425907104931441 no 1960 0.421510665674563 2745 1677248 YPR107C YTH1 SGTC_1833 st055984 71 µM -0.200052438107605 0.425152768431333 no 1961 0.420719785129568 2807 676288 SGTC_1393 3470-5649 58.2 µM -0.200247066050779 0.425080177829569 no 1962 0.420643679574743 2851 4108395 SGTC_664 1222-0054 14.9 µM -0.201916479787802 0.424457639303572 no 1963 0.419991009207872 2783 6813991 SGTC_586 0957-0265 8.15 µM -0.20270444867128 0.424163864386603 no 1964 0.419683022914137 2789 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2186 6124449 200 µM -0.203260699978154 0.423956505057482 no 1965 0.419465635588205 2919 3834182 YLR033W RSC58 SGTC_2418 pentamidine 31.67 µM -0.204890170854505 0.42334919236752 no 1966 0.41882896741767 2727 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3285 9112818 20.8695 µM -0.205020677216196 0.423300559789994 no 1967 0.418777985037949 2750 17017947 YPR165W RHO1 SGTC_3054 9094397 49.47 µM -0.205157709650426 0.423249496560118 no 1968 0.418724454712645 2813 2598354 SGTC_132 0417-1715 25.805 µM -0.205888261508088 0.422977288352867 no 1969 0.418439097488161 2837 6769098 SGTC_683 panaxydol 45 µM -0.206501758220717 0.422748724024766 no 1970 0.418199495739016 2818 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2314 7727897 200 µM -0.206515166398385 0.422743728964351 no 1971 0.418194259500559 2782 900724 SGTC_1649 st011737 51.3 µM -0.207971693819324 0.422201190771795 no 1972 0.417625534584674 2822 1761035 SGTC_2647 atorvastatin 60.16 µM -0.208235169617554 0.422103065076132 no 1973 0.417522674520801 2848 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2857 9024691 58.44 µM -0.209454857195212 0.421648882684064 no 1974 0.417046586236265 2892 16478292 SGTC_1269 0831-0796 3.05 µM -0.209671706729625 0.421568144013468 no 1975 0.416961954713766 2897 927758 SGTC_88 0180-0332 8.668 µM -0.211107899004452 0.421033496003721 no 1976 0.416401538309283 2756 3101745 SGTC_1242 0402-0103 60.1 µM -0.211244191142842 0.420982766390008 no 1977 0.416348364580029 2765 432868 SGTC_989 1501-0895 10.3 µM -0.211772209435291 0.42078624386807 no 1978 0.41614237521854 2808 2830112 SGTC_2104 5389443 200 µM -0.212719661334509 0.420433662351145 no 1979 0.415772815099024 2965 2244536 SGTC_2168 5727979 200 µM -0.212805357641117 0.420401774763608 no 1980 0.415739392334122 2720 695210 SGTC_775 4577-0580 57.3 µM -0.214078912490864 0.419927946804185 no 1981 0.415242759994338 2990 2006902 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.215517492840953 0.419392860468418 no 1982 0.414681937588148 2780 15053 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.217688664184837 0.418585566156967 no 1983 0.413835848276386 2862 6857784 SGTC_2352 9027995 87.8 µM -0.218998092464279 0.41809885435532 no 1984 0.413325766848061 2850 2997347 SGTC_1810 st050138 53 µM -0.219620477477218 0.417867559044539 no 1985 0.413083371015098 2848 3444541 SGTC_220 paclitaxel 373.376 µM -0.219898409102816 0.417764281213343 no 1986 0.412975137671029 2894 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2166 5933061 31.504 µM -0.221184599680757 0.417286413980377 no 1987 0.41247434999455 3308 2877375 SGTC_2775 cyproheptadine 69.59 µM -0.222829772603145 0.416675349701121 no 1988 0.411833997663656 2865 2913 A selective serotonin reuptake inhibitor. SGTC_56 0957-0365 83.25 µM -0.22497527167524 0.415878752598733 no 1989 0.410999255753997 2866 6752360 SGTC_230 MPP+ 141.667 µM -0.225931198555423 0.415523939915202 no 1990 0.410627466089997 2835 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2744 captopril 92.04 µM -0.226013579588554 0.415493365653895 no 1991 0.410595429299797 2885 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_492 tmb-8 126 µM -0.226166067048281 0.415436773984207 no 1992 0.410536130710104 2886 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1201 1889-3372 45.9 µM -0.227374195573979 0.414988471271174 no 1993 0.410066391893371 2838 5392199 SGTC_2504 purpurogallin 52.29 µM -0.227381258243308 0.414985850836908 no 1994 0.410063646198391 2794 5281571 An antioxidant. SGTC_347 4534-1311 26.2 µM -0.227949316562396 0.414775098801735 no 1995 0.409842821360085 2774 2862016 SGTC_60 0986-0278 202 µM -0.228628225689775 0.414523252827086 no 1996 0.409578942310498 2807 3110598 SGTC_280 3448-3607 3.04 µM -0.228717859662123 0.414490005116594 no 1997 0.409544106350378 2898 626179 SGTC_795 0685-0265 78 µM -0.228824275116669 0.414450533487344 no 1998 0.409502749247488 2807 302754 SGTC_105 0111-0055 734.78 µM -0.229511280850347 0.414195730072268 no 1999 0.409235776882512 2894 5179370 SGTC_677 0929-0063 136 µM -0.230170993077801 0.413951083525713 no 2000 0.408979450466089 2796 1539583 SGTC_1296 1068-0102 11.9 µM -0.231226908011559 0.41355957937911 no 2001 0.408569263395328 2910 767053 SGTC_2141 5621638 7.665 µM -0.233517458323449 0.412710602309135 no 2002 0.407679807232653 2954 2856238 SGTC_2070 5230947 200 µM -0.234043698204805 0.412515612550627 no 2003 0.407475527164892 2918 2835538 SGTC_99 0109-0120 622.8 µM -0.235300797024995 0.412049902190531 no 2004 0.406987638275587 2930 759414 SGTC_1020 4335-0961 93.3 µM -0.235601083620685 0.411938674995924 no 2005 0.406871116260228 2790 669075 SGTC_2524 avocatin b 10.57 µM -0.236425522273388 0.41163333646473 no 2006 0.406551246781298 2932 6710748 SGTC_442 cape 100 µM -0.238054617370412 0.411030143416015 no 2007 0.405919366516655 2961 5281787 SGTC_2696 st077691 74.316 µM -0.2382822205827 0.410945887160915 no 2008 0.405831105088693 2969 757133 SGTC_1382 3002-2117 298 µM -0.238391893601432 0.410905288858493 no 2009 0.405788577093397 2960 1497314 SGTC_2975 9084847 53.72 µM -0.238561840130886 0.410842380643655 no 2010 0.405722678986605 2928 27211724 SGTC_1253 0550-0034 176 µM -0.238627066492475 0.410818236752601 no 2011 0.405697387659972 2948 5969915 SGTC_3338 9144300 39.5675 µM -0.238631029831503 0.41081676971208 no 2012 0.405695850899803 2900 4901274 SGTC_321 4534-3890 65.3 µM -0.238830905839214 0.410742786692567 no 2013 0.405618352100717 2946 699746 SGTC_1702 st027038 51 µM -0.239239998541588 0.410591373152328 no 2014 0.40545974433486 2880 5521182 SGTC_2011 4012611 177 µM -0.241654800921703 0.409697877786777 no 2015 0.404523827618368 2828 2049887 SGTC_3317 9138495 8.753 µM -0.243136765445545 0.409149771377837 no 2016 0.4039497254407 2838 17020139 SGTC_281 1672-3440 14.9 µM -0.243150360961502 0.409144743879865 no 2017 0.403944459593207 2932 6833000 SGTC_1705 st027868 56.3335 µM -0.244814093575859 0.408529623774713 no 2018 0.403300190416714 2919 292948 SGTC_1115 galangin 695.678 nM -0.245936863222442 0.408114637303844 no 2019 0.40286555364915 2889 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3297 9117502 71.43 µM -0.245984859216254 0.408096899815795 no 2020 0.402846976530576 2857 7453720 SGTC_1068 loratadine 26.9 µM -0.247314992016287 0.407605408538866 no 2021 0.402332228576893 2889 3957 A H1 histamine antagonist. SGTC_1040 k898-0338 155 µM -0.247586419904104 0.407505132300382 no 2022 0.402227209498199 3074 20969351 SGTC_2926 9010726 65.15 µM -0.247628153406986 0.407489714824826 no 2023 0.402211062873753 2951 2994293 SGTC_539 4859-0462 2.54 µM -0.249261705022476 0.406886349842293 no 2024 0.40157917576697 3022 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2748 diazoxide 86.69 µM -0.249624758423743 0.406752283205272 no 2025 0.401438775073182 2927 3019 A potassium channel activatior. SGTC_3065 9113888 49.47 µM -0.249824625709248 0.406678481825456 no 2026 0.401361487450043 3045 16648368 SGTC_304 1310-0298 97 µM -0.250422106769407 0.406457880567166 no 2027 0.401130467703785 2870 1550234 SGTC_2737 bleomycin 30.5 nM -0.250493350819003 0.406431577902081 no 2028 0.401102923056361 2863 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1379 2144-0755 36.5 µM -0.25096053728381 0.406259107310178 no 2029 0.400922309822 3005 5392327 SGTC_1808 st050063 61.5 µM -0.251724407272095 0.405977149658917 no 2030 0.40062704503786 3000 4011993 SGTC_2786 7743617 45.45 µM -0.25190011344058 0.405912300359945 no 2031 0.400559135950438 2889 583674 SGTC_1757 st041620 31.8375 µM -0.252146382387726 0.405821412230053 no 2032 0.400463959948884 2921 5289815 SGTC_394 menadione 8.33 µM -0.253566115334129 0.405297544075357 no 2033 0.399915388620507 2979 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_548 1436-0017 110 µM -0.25359324689769 0.405287534431397 no 2034 0.399904907161404 2985 9677137 SGTC_2015 5119600 184 µM -0.253718031596971 0.405241498427467 no 2035 0.399856701295108 3043 2828786 SGTC_1123 mangostin 811.285 nM -0.253738176586676 0.405234066590909 no 2036 0.399848919180522 2927 5281650 An antioxidant. SGTC_2145 5634607 200 µM -0.254878515935677 0.40481343139318 no 2037 0.399408465089283 2846 308662 SGTC_822 1487-0950 154 µM -0.254894987812518 0.404807356242181 no 2038 0.399402103792002 2988 1958375 SGTC_1192 1488-0095 21.4 µM -0.256786259747488 0.404109971002295 no 2039 0.398671888816124 2927 915875 SGTC_1915 st067105 30.6 µM -0.25793242252764 0.403687484481219 no 2040 0.398229530851221 2829 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_269 exalamide 29 µM -0.259016796610519 0.403287877281604 no 2041 0.397811140405777 2878 3316 A derivative of salicylamide. SGTC_1172 0370-0043 85 µM -0.25914972831133 0.403238897007067 no 2042 0.397759858659476 3028 376585 SGTC_1338 1486-1223 76 µM -0.25951268775142 0.40310516799468 no 2043 0.397619846927815 2936 3444526 SGTC_1933 st074711 15.9 µM -0.260248344119117 0.402834157059131 no 2044 0.39733610769488 2821 17250958 SGTC_1732 st034308 51.822 µM -0.260586825242055 0.402709478525562 no 2045 0.397205575339871 2785 830119 SGTC_979 1426-2828 121 µM -0.26353504362317 0.401623930592161 no 2046 0.396069108470846 3019 747872 SGTC_2043 5101342 149 µM -0.26378537803669 0.401531791107682 no 2047 0.395972651135573 2903 678451 SGTC_537 1334-0398 209 µM -0.265001457177473 0.401084272195852 no 2048 0.39550416963559 3048 5846986 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.265462176610629 0.400914760625845 no 2049 0.395326721787338 3219 5282309 SGTC_911 3456-4043 236 µM -0.266505461309102 0.400530975988299 no 2050 0.394924976968691 2972 914281 SGTC_233 rapamycin 362 pM -0.267627463051349 0.400118341508111 no 2051 0.394493044691861 2904 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_159 3970-0959 50 µM -0.268896705677945 0.399651691193855 no 2052 0.394004586063804 2964 6615653 SGTC_195 4234-0266 16.654 µM -0.273168667126846 0.398082116419389 no 2053 0.392361782157081 2916 2303354 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.274832622192335 0.397471201972255 no 2054 0.391722416962555 3307 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_925 2064-1272 59.6 µM -0.274922928504285 0.397438053550003 no 2055 0.391687725628089 2910 6815817 SGTC_1107 amlodipine 47 µM -0.27510688455215 0.397370531737897 no 2056 0.391617061241173 2954 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_923 1900-2434 73.3 µM -0.275653164725631 0.397170035522645 no 2057 0.391407235714779 2853 5910570 SGTC_934 2950-0684 338 µM -0.276013442950432 0.397037820767004 no 2058 0.391268870588224 3101 1121253 SGTC_898 1000-0849 28.3 µM -0.277903065539288 0.396344561960126 no 2059 0.390543385301588 2991 6751807 SGTC_1545 lovastatin 49.4 µM -0.278325621842498 0.396189580574195 no 2060 0.390381204728072 2949 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_882 0843-0131 351 µM -0.279654032846127 0.395702464940074 no 2061 0.38987147404698 2888 5425421 SGTC_198 3454-2873 16.191 µM -0.280415095030943 0.395423464033341 no 2062 0.389579528636265 2907 710957 SGTC_3150 9097574 49.47 µM -0.280896542501608 0.395246995895813 no 2063 0.389394876309219 3056 17217476 SGTC_2226 7298446 200 µM -0.282696938274556 0.394587275514203 no 2064 0.388704581728825 3017 3283010 SGTC_1723 st034307 2.5525 µM -0.283138527889191 0.394425509577586 no 2065 0.388535324230413 2978 867466 SGTC_2605 digitonin 300 nM -0.283152404408301 0.394420426537104 no 2066 0.38853000582285 3027 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3125 9127534 49.47 µM -0.283468330507725 0.394304706043946 no 2067 0.388408927527606 2955 1639235 SGTC_2491 paeonol 100 µM -0.283503831144534 0.394291703107267 no 2068 0.388395322628961 2847 11092 Increases levels of cortical cytochrome oxidase. SGTC_3015 9080845 49.47 µM -0.284723785703997 0.393844937955953 no 2069 0.387927883108477 3041 5296973 SGTC_603 3794-0023 45.9 µM -0.284958565041077 0.393758974348152 no 2070 0.387837943331742 3018 3802260 SGTC_597 k018-0003 82.8 µM -0.285434493996331 0.393584730565563 no 2071 0.387655641903299 3024 6786234 SGTC_1824 st053723 68.6 µM -0.285617371236974 0.393517782493298 no 2072 0.387585598573478 2965 675225 SGTC_271 rotenone 740 µM -0.286252827813347 0.393285177742163 no 2073 0.387342242481638 3028 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_128 0906-2981 13.371 µM -0.286751303934746 0.393102740449025 no 2074 0.387151375753175 3075 6740226 SGTC_2428 5615643 7.78 µM -0.287489469670068 0.392832622276222 no 2075 0.386868781888227 3039 2253075 SGTC_574 1315-0397 40 µM -0.288354172506356 0.392516265814395 no 2076 0.386537821777493 2907 6794277 SGTC_2908 7930301 100 µM -0.289482892315948 0.392103424103638 no 2077 0.386105934848057 2911 2223178 SGTC_1060 3448-7350 82 µM -0.290641505720191 0.391679774777565 no 2078 0.385662756356728 3042 570178 SGTC_947 3447-0010 211 µM -0.291380270421248 0.391409710993419 no 2079 0.385380251075246 2901 748350 SGTC_2198 6589944 200 µM -0.291445416589525 0.391385898584677 no 2080 0.385355341949506 2948 5290268 SGTC_1835 st008666 49.2 µM -0.291889707014191 0.39122351117063 no 2081 0.38518547679149 2918 690455 SGTC_385 1494-0393 12.4 µM -0.295200189194594 0.390014134170078 no 2082 0.383920478737481 2962 3090647 SGTC_1938 st074717 56.4 µM -0.296284282401286 0.389618326632549 no 2083 0.383506494106697 2873 17250979 SGTC_684 1140-0066 328 µM -0.299756264282505 0.388351461879167 no 2084 0.382181539041626 2993 6813534 SGTC_827 3253-0474 693 µM -0.300521709316055 0.388072323739045 no 2085 0.38188961981386 3068 5402065 SGTC_1132 3456-3614 2.5 µM -0.301231004008439 0.387813713792196 no 2086 0.381619174680915 3191 3125502 SGTC_1021 4476-0760 85.3 µM -0.3035520291806 0.386967812757825 no 2087 0.380734601541937 2945 746768 SGTC_478 N-arachidonylglycine 10 µM -0.303795602846401 0.38687907301906 no 2088 0.380641808468528 3030 5283389 SGTC_1816 st051957 91.6 µM -0.303857201342064 0.386856632143698 no 2089 0.380618342677151 2969 674121 SGTC_991 3996-0057 64.7 µM -0.304829391688595 0.386502504765645 no 2090 0.380248047440242 3027 715343 SGTC_1866 st057638 64 µM -0.305435365696844 0.386281822132512 no 2091 0.380017294950495 2961 688802 SGTC_2824 7998404 51.95 µM -0.305471391057243 0.386268703632755 no 2092 0.380003577980809 2924 837851 SGTC_1717 st033143 58.0435 µM -0.305832567486486 0.386137189779834 no 2093 0.379866065255811 3116 674616 SGTC_1518 st038567 90.8 µM -0.306457532202874 0.385909654573503 no 2094 0.379628154827634 2972 77966 SGTC_2607 solasodine 47.35 µM -0.306816142200503 0.385779110678019 no 2095 0.37949166039498 2954 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1258 0671-0043 57.1 µM -0.30974636503158 0.384712914934643 no 2096 0.378376920667861 2993 4298767 SGTC_3265 9137266 49.47 µM -0.310023681208552 0.384612055218809 no 2097 0.378271473991428 3036 17224265 SGTC_1929 genistein trimethyl ether 50.5 µM -0.310468063108811 0.384450450093137 no 2098 0.378102521165877 3145 136420 SGTC_398 bronopol 33.3 µM -0.310476972750223 0.384447210194049 no 2099 0.378099133981972 2927 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_780 0109-0199 192 µM -0.310662122931697 0.384379884069759 no 2100 0.37802874744343 3136 610414 SGTC_451 chloral hydrate 100 µM -0.312117033856418 0.383850956631699 no 2101 0.377475790792247 3074 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_126 0417-1624 672.48 µM -0.31359236992633 0.383314824578064 no 2102 0.376915327673588 3059 41912 YDL195W SEC31 SGTC_147 4466-0538 29.23 µM -0.316084170467777 0.382409820560009 no 2103 0.37596931070821 3180 6742687 YHR072W ERG7 SGTC_3106 9121286 49.47 µM -0.316266586690891 0.382343593457552 no 2104 0.375900085225179 3164 15943471 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.316631097680761 0.382211266270088 no 2105 0.375761768214642 3033 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1762 st045503 25.4615 µM -0.316650265344972 0.382204308278582 no 2106 0.375754495311746 3036 4645554 SGTC_1882 5615643 20 µM -0.316694642829295 0.38218819909818 no 2107 0.375737657063565 3007 2253075 SGTC_202 3594-0513 34.79 µM -0.318049047811337 0.381696643616267 no 2108 0.375223866117408 2971 708429 SGTC_2240 6690706 185.951 µM -0.318783025652939 0.381430339970216 no 2109 0.374945525418213 2873 805876 SGTC_556 4058-0063 51.5 µM -0.319647243925603 0.381116854123159 no 2110 0.374617878141131 3017 6615692 SGTC_861 0443-0273 110 µM -0.319979050937845 0.38099651542398 no 2111 0.374492105637345 3064 6149169 SGTC_1804 st050076 49.1 µM -0.320186848272113 0.380921158015529 no 2112 0.374413346195411 3093 3895976 SGTC_1498 4478-3555 97.6 µM -0.322208436121692 0.380188268156492 no 2113 0.373647396958526 2988 3437919 SGTC_465 cgp-37157 41 µM -0.32311892688577 0.37985832658354 no 2114 0.373302588432653 3024 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_630 4356-0227 183 µM -0.323296477694583 0.379793996305475 no 2115 0.373235360644852 2993 779312 SGTC_2055 5235184 200 µM -0.323377810442968 0.379764528903281 no 2116 0.373204566124707 3136 2836034 SGTC_631 k072-0230 41.5 µM -0.323726124160128 0.379638340398571 no 2117 0.37307269540002 3077 5773147 SGTC_862 0452-0056 10.2 µM -0.325435597005082 0.379019211710141 no 2118 0.37242570897394 3057 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2204 7233102 200 µM -0.327646694790265 0.378218867243624 no 2119 0.371589405853701 2990 2172480 SGTC_2893 9048488 25.97 µM -0.32975348875675 0.377456763104987 no 2120 0.370793116961067 3025 6467338 SGTC_897 1000-0139 31.4 µM -0.329766573986437 0.37745203118788 no 2121 0.370788172961083 3134 6151020 SGTC_3020 9089140 49.47 µM -0.330355194022329 0.377239191811827 no 2122 0.370565796384549 3069 17217859 SGTC_2831 7999036 19.48 µM -0.330390700240846 0.377226354294534 no 2123 0.370552383762933 3233 2988270 SGTC_113 0099-0221 2.5 µM -0.330876800828086 0.3770506149368 no 2124 0.370368773074631 3175 89219 SGTC_842 0271-0008 11.1 µM -0.33152124789188 0.376817668033243 no 2125 0.370125397034316 3119 1221709 SGTC_386 1509-0011 3.07 µM -0.334095289414267 0.375887682720353 no 2126 0.369153827277983 2984 3107280 SGTC_1154 4088-0362 150 µM -0.334190494746477 0.375853299404543 no 2127 0.369117908088411 2972 6618304 SGTC_3100 9120536 49.47 µM -0.337884606314679 0.374519938086181 no 2128 0.367725074216341 3021 16421196 SGTC_698 k064-0052 127 µM -0.338553598571263 0.374278630306885 no 2129 0.367473021601417 3063 5088751 SGTC_3105 9121040 49.47 µM -0.338659758044099 0.374240342749218 no 2130 0.367433029712785 3043 41448907 SGTC_1426 4048-4480 71.7 µM -0.3407036453979 0.373503434991646 no 2131 0.366663347035323 3114 14224343 SGTC_395 anisomycin 6.25 µM -0.342490431163078 0.372859601833534 no 2132 0.365990921952812 3059 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2125 5246583 200 µM -0.342633879203571 0.372807928519311 no 2133 0.365936955644406 3164 835267 SGTC_2175 5807670 165.306 µM -0.343508488139732 0.372492923624202 no 2134 0.365607978138772 3153 241186 SGTC_1094 duloxetine 25.4 µM -0.343515002782338 0.372490577587465 no 2135 0.365605528075967 2995 60834 A selective serotonin reuptake inhibitor. SGTC_422 cantharidin 155 µM -0.344705196272183 0.372062047567898 no 2136 0.365158005626054 2948 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_164 4100-3994 89.624 µM -0.344733089459666 0.372052006503515 no 2137 0.365147519759523 3137 4615967 SGTC_2320 7373003 200 µM -0.346886180820545 0.371277193964381 no 2138 0.364338414454455 3072 5415828 SGTC_2808 7946468 45.46 µM -0.348683194633344 0.370630918687314 no 2139 0.363663581066766 3084 2970879 SGTC_1900 st060200 72.8 µM -0.349275869204379 0.37041785004373 no 2140 0.363441106328036 3001 688945 SGTC_2453 5731132 22.18 µM -0.350076075824591 0.370130235951639 no 2141 0.363140802485644 3176 1362040 SGTC_2124 5246320 200 µM -0.350529461307576 0.369967310184293 no 2142 0.362970691996191 3101 579342 SGTC_3349 9149703 23.001 µM -0.350948782880243 0.369816646180127 no 2143 0.362813386366871 2997 4910494 SGTC_2435 5706476 10.6 µM -0.352237143123846 0.36935385802725 no 2144 0.362330211727661 3172 5725375 SGTC_2937 9044753 11.33 µM -0.353001994358932 0.369079207510915 no 2145 0.362043472692689 2969 6465530 YGL099W LSG1 SGTC_1976 st070609 63.5 µM -0.353964933104503 0.368733520770455 no 2146 0.361682581699332 2969 682556 SGTC_2406 ethylparaben 405.7 µM -0.355337885053198 0.368240826493729 no 2147 0.361168238371735 2921 8434 A possible steroid mimic. SGTC_306 1672-3436 11.6 µM -0.35536278986854 0.368231891208688 no 2148 0.361158910697481 3132 6797378 SGTC_1209 2323-2347 50.3 µM -0.355666348129742 0.368122987093374 no 2149 0.361045224759619 3129 5412760 SGTC_1285 0929-0069 65.5 µM -0.35592773354708 0.368029221336104 no 2150 0.360947342853734 3053 1206237 SGTC_1261 0712-0010 12.7 µM -0.355970879875816 0.368013744380066 no 2151 0.360931186573473 3216 2840123 SGTC_360 0957-0399 1.01 µM -0.358680949795925 0.367042049502508 no 2152 0.359916890619427 3180 6752301 YPR165W RHO1 SGTC_1837 st055472 66.5 µM -0.360147535814179 0.366516559962514 no 2153 0.359368403041581 3205 676091 SGTC_2767 sibutramine 71.45 µM -0.361689932264251 0.36596417680141 no 2154 0.358791875658981 3246 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2272 7805186 180 µM -0.362332416429211 0.365734163850503 no 2155 0.358551818375229 3174 2956062 YPR165W RHO1 SGTC_2973 9094665 17.96 µM -0.362342640896925 0.36573050382337 no 2156 0.358547998564524 3234 25237061 YIL048W NEO1 SGTC_1761 st044296 37 µM -0.362951286722095 0.365512650430158 no 2157 0.358320636993568 3016 1826700 SGTC_1958 st076513 41.9 µM -0.363316251768783 0.365382038814459 no 2158 0.358184327228333 3017 732122 YGL099W LSG1 SGTC_2282 7944268 200 µM -0.363707535465061 0.365242025769888 no 2159 0.358038207860484 3240 2970414 SGTC_1509 1326-1131 80 µM -0.364391140411156 0.364997454521444 no 2160 0.357782975160944 3147 768313 SGTC_2408 sulbentine 18.36 µM -0.364667219822781 0.364898697996522 no 2161 0.35767991537663 3052 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2693 st077581 40.7 µM -0.365990801330496 0.364425363476054 no 2162 0.357185969788663 3185 25238761 SGTC_799 1310-0557 151 µM -0.369782731106431 0.363070453334525 no 2163 0.355772191613539 3211 5354492 SGTC_1412 3909-8563 178 µM -0.372069551604027 0.362254166396015 no 2164 0.354920532895843 3176 23767530 SGTC_1226 3909-7979 35.4 µM -0.372260366348995 0.362186082786693 no 2165 0.354849502270785 3170 6615510 SGTC_2173 5763948 167 µM -0.380883378743717 0.359113931227269 no 2166 0.351644893194889 3097 2867177 SGTC_2088 5278280 127.392 µM -0.382824596244379 0.358423572952477 no 2167 0.350924911540502 3168 791502 SGTC_1217 1183-1422 255 µM -0.386560210087207 0.357096373540295 no 2168 0.349540909955035 3221 2849664 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.387064263349448 0.356917423986973 no 2169 0.349354316624433 2996 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2916 7875993 68.79 µM -0.38905640652822 0.356210479475291 no 2170 0.348617210241989 3234 1299250 SGTC_2365 9042475 200 µM -0.389759678493943 0.355961029781473 no 2171 0.348357131141084 3201 6464479 SGTC_19 0279-0214 38.434 µM -0.391405430651845 0.355377524628389 no 2172 0.34774878939725 3102 3566274 YBR002C RER2 SGTC_2706 st078239 82.5 µM -0.393136147609489 0.354764260554528 no 2173 0.347109463584709 3133 15434492 SGTC_3238 9133470 49.47 µM -0.394212555030838 0.354383034843424 no 2174 0.34671205855285 3219 3534688 SGTC_2202 7226349 200 µM -0.394556376315976 0.354261296133353 no 2175 0.346585156708096 3084 844334 SGTC_3103 9120822 49.47 µM -0.394609922108548 0.354242338217344 no 2176 0.346565394908525 3331 17141819 SGTC_371 0195-0006 7.36 µM -0.396726502161114 0.35349325170951 no 2177 0.345784577348492 3054 3928593 SGTC_2825 7998094 58.44 µM -0.396923688282334 0.353423493688 no 2178 0.345711867674149 3130 2987815 SGTC_1207 2099-0101 141 µM -0.397810567267244 0.353109805714338 no 2179 0.345384913616942 3202 5837381 SGTC_521 r062-0005 13.8 µM -0.39791960577148 0.353071245817971 no 2180 0.345344723777135 3090 2832033 SGTC_1590 st077108 57.8 µM -0.398723795737288 0.352786902240371 no 2181 0.345048366165467 3204 5489485 SGTC_1414 3917-0015 5.4 µM -0.399743000667733 0.352426652317459 no 2182 0.344672908433702 3209 6618702 SGTC_1714 st033236 13.627 µM -0.400880383556623 0.352024787265769 no 2183 0.344254096536339 3286 2916566 SGTC_2712 st079126 47.7 µM -0.402374441716635 0.351497151267066 no 2184 0.343704238354656 3090 3152970 SGTC_404 fumagillin 50 µM -0.403740679545454 0.351014906124318 no 2185 0.343201711121371 3183 12015870 A methionine aminopeptidase binder. SGTC_1756 st041558 35.5 µM -0.403773649405948 0.351003271612781 no 2186 0.343189587625605 3290 3955792 SGTC_2329 6138490 200 µM -0.404689022727894 0.350680307508107 no 2187 0.342853056065081 3275 720019 SGTC_2813 7971799 71.43 µM -0.406207594526823 0.350144759574164 no 2188 0.34229503719052 3200 2234054 SGTC_2387 9077560 195.08 µM -0.406327811222152 0.350102375999623 no 2189 0.342250876693725 3120 5303272 SGTC_2188 6126565 140.678 µM -0.407467733588788 0.349700578050599 no 2190 0.341832243977752 3228 874518 SGTC_844 0330-0132 15.3 µM -0.407818860187504 0.349576847410109 no 2191 0.34170333303853 3234 2828079 SGTC_916 4466-0038 42 nM -0.40951598954669 0.348979035290847 no 2192 0.341080517539784 3332 5722064 YGL116W CDC20 SGTC_1853 st056710 91.2 µM -0.409651695674393 0.348931249100148 no 2193 0.341030734531526 3272 269167 SGTC_1238 0333-0287 48.8 µM -0.410177424423888 0.348746146892339 no 2194 0.340837900114402 3156 7226 SGTC_3044 9093193 49.47 µM -0.4115439595789 0.348265176246107 no 2195 0.340336857137643 3206 25236277 SGTC_742 0kpi-0133 140 µM -0.41178614287509 0.348179961961875 no 2196 0.340248089488755 3262 2728852 SGTC_1149 3909-7961 23.3 µM -0.412199334325676 0.348034594676631 no 2197 0.340096662513254 3155 735261 SGTC_3353 9151644 39.2805 µM -0.413276678326307 0.34765567307976 no 2198 0.339701957324663 3246 4909158 SGTC_845 0330-0138 4.51 µM -0.413297652956139 0.347648297427369 no 2199 0.339694274617884 3184 9039800 SGTC_296 1222-0039 74.9 µM -0.413657833248968 0.347521650335524 no 2200 0.339562356124199 3159 5984176 SGTC_1773 st048542 73.5835 µM -0.414892613837654 0.347087604330422 no 2201 0.339110258560223 3123 3237138 SGTC_2420 aureobasidin a 50 nM -0.419064960399025 0.34562244124729 no 2202 0.337584328934157 3364 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2788 5282734 71.43 µM -0.419611983257043 0.345430519237657 no 2203 0.337384466426373 3285 743706 SGTC_3184 9108758 49.47 µM -0.420416928572367 0.34514817784704 no 2204 0.337090451740862 3130 902885 SGTC_40 0327-0103 19.753 µM -0.420924272674909 0.344970266866831 no 2205 0.336905190108039 3125 409036 SGTC_2456 5770359 74.46 µM -0.423383591396394 0.344108340828298 no 2206 0.336007707325288 3286 3118787 SGTC_563 tetrahydrosecaminediol 614 µM -0.424610183048831 0.343678755136546 no 2207 0.335560434246359 3287 334274 A psychoactive constituent of the cannabis plant. SGTC_1622 st003707 19.4 µM -0.424632730019003 0.343670860462618 no 2208 0.335552214737379 3255 10140899 SGTC_3111 9122088 49.47 µM -0.425434534389891 0.343390158259726 no 2209 0.335259967747017 3153 16876704 SGTC_1461 k072-0203 53.8 µM -0.425809210549929 0.343259018176457 no 2210 0.335123437449137 3186 5418714 SGTC_317 4495-0002 170 µM -0.426725246680679 0.342938476649602 no 2211 0.334789729778862 3192 15991618 SGTC_1177 0983-0204 23.6 µM -0.426924497862023 0.342868769161949 no 2212 0.334717160768495 3283 766818 SGTC_854 0422-0053 192 µM -0.427038897964668 0.342828749011941 no 2213 0.334675498047111 3230 3596728 SGTC_1612 st002233 45.4 µM -0.427060096697722 0.342821333333967 no 2214 0.334667778024843 3248 1035021 SGTC_655 k060-0012 42 µM -0.427238547523095 0.342758910595907 no 2215 0.334602793688002 3154 5994525 SGTC_659 k018-0002 107 µM -0.427445308297847 0.342686590304693 no 2216 0.334527506245768 3274 6797879 YHR007C ERG11 SGTC_2545 solidagenone 89.61 µM -0.42949413463799 0.34197026870287 no 2217 0.33378183071214 3065 6708572 An anti ulcer agent SGTC_908 3448-7491 47.7 µM -0.430059157731133 0.341772822204215 no 2218 0.333576304397754 3147 1203031 SGTC_2947 9072639 7.68 µM -0.431725949957515 0.341190616389851 no 2219 0.332970302321763 3238 16488146 SGTC_2928 9011484 9.79 µM -0.432375227757964 0.340963927672481 no 2220 0.332734359790023 3272 2994751 SGTC_2532 xanthone 78.9 µM -0.43328288393927 0.340647125006652 no 2221 0.332404635574326 3250 7020 An insecticide. SGTC_1941 st076221 61.8 µM -0.433721091979403 0.340494215809571 no 2222 0.332245494153096 3259 2828568 SGTC_2653 dihydrofissinolide 100 µM -0.437707317045269 0.339104460992088 no 2223 0.330799232321043 3279 6857746 SGTC_1802 st050112 57.9 µM -0.438225469882368 0.338923972714244 no 2224 0.330611423520316 3205 4662563 SGTC_148 3253-0744 288.01 µM -0.438348528928204 0.338881112964272 no 2225 0.330566826011247 3261 6893655 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.438595015249317 0.338795271488325 no 2226 0.330477504779532 3193 6312947 SGTC_1292 0kpi-0043 232 µM -0.439342024067442 0.338535168891001 no 2227 0.330206864175271 3219 3333905 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.439682509825258 0.338416639967311 no 2228 0.330083535956837 3353 94937 An inhibitor of serotonin biosynthesis. SGTC_3322 9139058 2.11 µM -0.440125862761465 0.338262325210522 no 2229 0.329922975626449 3335 4908926 YPR165W RHO1 SGTC_1042 0350-0096 82 µM -0.441163618013533 0.337901227237262 no 2230 0.329547274938025 3169 3122515 SGTC_2123 5259487 200 µM -0.443047701238698 0.337246021764135 no 2231 0.328865616117481 3280 2173474 SGTC_1088 bifonazole 369 nM -0.443602156354568 0.337053299284105 no 2232 0.328665123220711 3249 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_652 0437-0092 114 µM -0.44371738529346 0.337013252341755 no 2233 0.32862346222266 3223 3091274 SGTC_1334 1486-0610 236 µM -0.443853412466618 0.336965979508588 no 2234 0.328574284368943 3273 3742339 SGTC_1133 3473-0247 50 µM -0.444689179650225 0.336675586117537 no 2235 0.32827219495779 3187 711311 SGTC_1298 1079-1278 263 µM -0.444929699604461 0.336592033742213 no 2236 0.328185279421315 3244 2840950 SGTC_3061 glucosamine 200 µM -0.446045484559401 0.336204535362461 no 2237 0.32778219530741 3294 91431 and experimental redox chemotherapeutic SGTC_965 1291-5240 308 µM -0.447124580101122 0.335829944230823 no 2238 0.327392556240838 3310 2834598 SGTC_2863 9028737 58.44 µM -0.448708471146487 0.335280416593037 no 2239 0.326820986468684 3227 6460917 SGTC_583 1488-1091 88.9 µM -0.450148422115296 0.334781134324772 no 2240 0.326301711900658 3293 4303273 SGTC_3261 9137475 49.47 µM -0.450182939373466 0.334769169541919 no 2241 0.326289268426363 3204 17027690 SGTC_811 0416-0114 265 µM -0.450300426344008 0.334728446067087 no 2242 0.326246915813407 3308 6612453 SGTC_1166 k206-0078 225 µM -0.450621941661458 0.334617011981093 no 2243 0.326131024939 3207 5404595 SGTC_2101 5377231 179.231 µM -0.451340582936959 0.334367990571357 no 2244 0.325872049892375 3296 2844213 SGTC_477 mead ethanolamide 10 µM -0.451847894030919 0.334192242528281 no 2245 0.325689281964729 3213 16061185 SGTC_1452 4194-0072 190 µM -0.452430809212411 0.333990347797405 no 2246 0.32547932802997 3329 1343545 SGTC_382 3229-0966 23.2 µM -0.454721609888885 0.333197386697558 no 2247 0.324654766076355 3352 5722370 SGTC_2423 st077119 87.2 µM -0.456106965590121 0.332718206825883 no 2248 0.324156530741018 3256 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3236 9132701 49.47 µM -0.456307534882293 0.332648854648009 no 2249 0.324084423193375 3265 24282524 SGTC_3168 9103419 49.47 µM -0.456471153967658 0.332592283230183 no 2250 0.324025604664327 3260 16649256 SGTC_847 0342-0274 5.54 µM -0.456723670697831 0.332504982869143 no 2251 0.323934837429474 3294 18097 SGTC_1118 chelidonine 707.474 nM -0.457805038586189 0.332131233973306 no 2252 0.323546257780583 3308 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_552 k242-0005 476 µM -0.458192125215473 0.331997487307384 no 2253 0.323407208469306 3320 4088318 SGTC_895 0964-0006 13.7 µM -0.458543724105866 0.331876020958788 no 2254 0.323280928440036 3331 6738897 SGTC_2165 5727197 32.143 µM -0.458826602590745 0.33177830817273 no 2255 0.323179344764538 3501 1361712 SGTC_1892 st058411 7.36 µM -0.459117723764309 0.33167776011873 no 2256 0.323074814846732 3304 3934738 SGTC_3151 9099821 49.47 µM -0.459572640291527 0.331520664355506 no 2257 0.322911500572489 3295 17174189 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.459693061710553 0.331479084334653 no 2258 0.322868275197647 3201 688803 SGTC_1248 0469-0687 58.6 µM -0.459714669445624 0.331471623671762 no 2259 0.322860519335213 3276 4017482 SGTC_1052 3253-3998 198 µM -0.459950752287288 0.331390113955803 no 2260 0.322775784976489 3183 5450317 SGTC_3224 9130643 49.47 µM -0.460188748702063 0.33130795164485 no 2261 0.322690373114795 3382 17644395 SGTC_3145 9085516 49.47 µM -0.460321867220657 0.331261999345541 no 2262 0.322642603782939 3282 25236195 SGTC_1241 0364-0022 50.8 µM -0.460611769730208 0.331161934256108 no 2263 0.322538582938009 3223 4563895 SGTC_1656 st012921 11 µM -0.461214116186939 0.330954062048028 no 2264 0.32232249750046 3275 6732821 SGTC_250 brefeldin a 552.239 µM -0.461753391863436 0.330768000025113 no 2265 0.322129088962443 3221 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2442 5158906 48.48 µM -0.462215145995279 0.330608717866533 no 2266 0.321963521408129 3318 1893835 SGTC_1641 st009299 47.1 µM -0.462492003852342 0.33051323041325 no 2267 0.321864267601453 3298 4046054 SGTC_1191 1487-1166 10.6 µM -0.46273175729196 0.330430549076494 no 2268 0.321778326031238 3310 3955771 SGTC_2818 7996756 12.99 µM -0.4634696708527 0.330176124265167 no 2269 0.321513874759986 3155 2241621 SGTC_1989 st071868 50.2 µM -0.463964852828925 0.330005434753504 no 2270 0.321336463607707 3325 16414057 SGTC_948 3448-0295 75.3 µM -0.46456968093381 0.329796998162881 no 2271 0.321119824320219 3280 678569 SGTC_1215 3852-0577 11.2 µM -0.466086489623772 0.329274506273326 no 2272 0.320576796724852 3360 2884876 SGTC_1150 3909-7983 10.9 µM -0.466124742854133 0.329261333567771 no 2273 0.320563106771188 3233 23965914 SGTC_156 3474-0145 5.642 µM -0.47220855137079 0.327169048100081 no 2274 0.318388968272933 3336 2265471 SGTC_2037 5169046 200 µM -0.472530304821934 0.327058544049454 no 2275 0.318274158042208 3320 5718022 SGTC_232 clozapine 119 µM -0.472637807241263 0.327021626447685 no 2276 0.318235802195447 3274 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_75 0159-0059 199.013 µM -0.473023357826356 0.326889237742104 no 2277 0.318098257422446 3477 5377270 SGTC_1683 st010134 710 nM -0.473635313812184 0.32667915166021 no 2278 0.317879994263487 3205 3818134 SGTC_2948 9070189 9.45 µM -0.473939469023431 0.326574754821626 no 2279 0.317771536333894 3316 6473636 YDL196W YDL196W SGTC_1693 xanthone 101.9 µM -0.474593572571699 0.326350289335154 no 2280 0.317538344192197 3262 7020 An insecticide. SGTC_1073 triclabendazole 3.09 µM -0.475074479766649 0.326185298888298 no 2281 0.31736694383456 3335 50248 An antihelmetic and likely tubulin inhibitor. SGTC_610 4215-0184 155 µM -0.476184130649036 0.325804727836175 no 2282 0.316971602103196 3299 5605015 SGTC_1881 5652484 16 µM -0.477073228606105 0.325499929552546 no 2283 0.316654988722719 3329 2255129 SGTC_351 caspofungin 25 nM -0.477149593713659 0.325473755699392 no 2284 0.316627800885785 3261 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1680 diphenhydramine 100 µM -0.477496456961807 0.325354880461268 no 2285 0.316504321597924 3232 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1985 st071382 65.5 µM -0.477754293184372 0.325266527631506 no 2286 0.316412548146806 3300 6123237 SGTC_2870 9038528 12.99 µM -0.478244756209957 0.325098487606266 no 2287 0.316238005417046 3344 6463316 SGTC_622 1348-1566 26.3 µM -0.479076366119004 0.324813646811238 no 2288 0.315942151162513 3296 7340407 SGTC_63 0099-0242 26.702 µM -0.480325317632626 0.324386051701279 no 2289 0.315498044547672 3362 3898502 YLR359W ADE13 SGTC_282 k297-0036 65.7 µM -0.48139930994288 0.324018541250305 no 2290 0.315116363516616 3347 5061378 SGTC_52 0329-0193 875 nM -0.481913546924374 0.323842634684419 no 2291 0.314933681100623 3428 3739292 SGTC_1555 citronellol 128 µM -0.481922994431573 0.32383940331556 no 2292 0.314930325302022 3307 8842 A terpine precursor. SGTC_2212 7123476 200 µM -0.483043671372139 0.323456187936449 no 2293 0.314532364092784 3286 1085715 SGTC_1971 st069429 63.5 µM -0.486284499290416 0.322349041622621 no 2294 0.313382733897137 3329 1246522 YGL099W LSG1 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.486712750617798 0.322202857992914 no 2295 0.313230954028017 3364 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2008 4012253 172 µM -0.488001564520843 0.321763087220328 no 2296 0.312774366447457 3235 603940 SGTC_2219 9098279 200 µM -0.488607868815207 0.321556289556005 no 2297 0.312559670527139 3334 902349 SGTC_2220 6782180 200 µM -0.490273992074478 0.32098829475394 no 2298 0.311970014140457 3304 833803 SGTC_2840 9008771 71.43 µM -0.491498981119744 0.320570953106887 no 2299 0.311536786279106 3295 2992978 SGTC_2644 guaiazulene 100 µM -0.491608767393311 0.320533561073417 no 2300 0.311497972148587 3339 3515 A coloring agent. SGTC_964 1287-0107 19.4 µM -0.492389132308535 0.320267829613087 no 2301 0.311222140250696 3391 51516812 YPR165W RHO1 SGTC_1196 1588-0294 184 µM -0.492572723090044 0.320205326287944 no 2302 0.311157262677738 3299 6144269 SGTC_2986 9022445 71.43 µM -0.496949156612458 0.318716886771732 no 2303 0.309612452873522 3382 6459286 SGTC_1992 st073643 23.3 µM -0.497272114985283 0.318607162963346 no 2304 0.309498586521539 3299 3161292 SGTC_1400 3771-8998 51.5 µM -0.498205172162644 0.318290249914021 no 2305 0.309169718656796 3280 670767 SGTC_264 promethazine 12.5 mM -0.498832699134174 0.318077185015535 no 2306 0.308948624747 3422 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_769 0302-0231 76 µM -0.501390854416138 0.317209235282038 no 2307 0.308048037495301 3371 571869 YER009W NTF2 SGTC_1729 st035615 45.989 µM -0.502654225315385 0.316780959714465 no 2308 0.307603698912231 3323 17385451 SGTC_1153 4055-0057 267 µM -0.503080793728066 0.316636410838862 no 2309 0.307453734748962 3285 882706 SGTC_1018 4259-0013 28.1 µM -0.503360481971148 0.31654164962778 no 2310 0.307355425164508 3365 6801262 SGTC_1181 1222-0449 220 µM -0.505068596582287 0.315963184598145 no 2311 0.306755328529879 3437 658318 SGTC_1017 4239-0030 168 µM -0.505521454309267 0.31580989660917 no 2312 0.306596316805659 3293 1149593 SGTC_2552 juarezic acid 87.02 µM -0.505648503333512 0.315766897423543 no 2313 0.30655171267767 3347 1549512 SGTC_1766 st045414 44.774 µM -0.506117373272789 0.315608232030215 no 2314 0.306387127521762 3354 253960 SGTC_1827 berberine 7.24 µM -0.506127528546376 0.315604795865731 no 2315 0.306383563196976 3237 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.506541294742349 0.315464806431458 no 2316 0.306238354025686 3301 6708630 An antioxidant. SGTC_3309 9129340 25.759 µM -0.50893337824208 0.314656012904188 no 2317 0.305399461407194 3314 17158987 SGTC_1358 1509-0022 2.48 µM -0.50913197801629 0.314588903713819 no 2318 0.305329859223165 3364 3258434 SGTC_878 0828-0289 13.7 µM -0.509277162305215 0.314539848116938 no 2319 0.305278981726729 3319 745350 YLR208W SEC13 SGTC_1497 4476-2978 41.3 µM -0.509314754185235 0.314527146917239 no 2320 0.305265808870707 3376 1528379 SGTC_1440 4100-1550 40 µM -0.509931016491933 0.314318961164043 no 2321 0.305049895685208 3344 742806 SGTC_2970 9090938 41.86 µM -0.510005380621087 0.314293843462743 no 2322 0.305023846112237 3436 17217104 SGTC_1302 1159-0335 255 µM -0.510171776370989 0.314237643690546 no 2323 0.304965561665754 3303 649284 SGTC_927 2425-1185 123 µM -0.512499109256834 0.313452044313645 no 2324 0.304150871774502 3240 730375 SGTC_1786 berberine 21.6 µM -0.515617779075928 0.31240065230786 no 2325 0.303060695178824 3357 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2451 5856223 45.7 µM -0.517270558400827 0.311844071371546 no 2326 0.302483651662 3318 2179896 SGTC_80 0159-0065 512.242 µM -0.517475085438082 0.311775225797196 no 2327 0.30241227832806 3378 1548079 SGTC_2127 5253358 187.912 µM -0.517589478289577 0.31173672303933 no 2328 0.302372362209148 3264 20612 SGTC_2983 9022671 12.99 µM -0.519359115738136 0.311141354459547 no 2329 0.301755168118297 3437 6405161 SGTC_69 0096-0274 206.684 µM -0.519860657940573 0.31097270767993 no 2330 0.301580348970539 3549 6741392 SGTC_904 1141-0088 396 µM -0.521833895795384 0.31030957933256 no 2331 0.300892993584858 3353 1378119 SGTC_656 4090-1979 187 µM -0.526677271193873 0.30868452533567 no 2332 0.299208860951471 3440 22330961 SGTC_2095 5432005 200 µM -0.527138727404942 0.308529891726203 no 2333 0.299048627374614 3308 783734 SGTC_1558 st069300 45.6 µM -0.529245019085459 0.307824506579764 no 2334 0.298317745254094 3397 24208000 SGTC_107 0358-0022 2.6945 µM -0.530942535232637 0.307256534270574 no 2335 0.297729300500356 3386 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1922 5578187 25 µM -0.531433319626013 0.307092408647402 no 2336 0.297559268600364 3489 1350412 SGTC_1720 st037298 9.481 µM -0.53248488029936 0.306740881196616 no 2337 0.297195105484804 3384 597396 SGTC_3049 9092223 49.47 µM -0.53268995201564 0.306672348224907 no 2338 0.29712411140141 3393 8623917 SGTC_2361 9034121 116 µM -0.532892942443373 0.306604517455438 no 2339 0.297053845479682 3325 6496917 SGTC_2046 4110841 106 µM -0.533253827472648 0.306483941381336 no 2340 0.296928942499776 3459 44119630 YMR134W ERG29 SGTC_455 paf C-16 10 µM -0.534431624505389 0.306090570870085 no 2341 0.296521472035966 3372 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1993 st073995 70.8 µM -0.534432955736043 0.306090126380896 no 2342 0.296521011628623 3356 3098394 SGTC_739 1486-1183 203 µM -0.535478252738681 0.305741196731122 no 2343 0.296159595855353 3436 4346692 SGTC_2022 5136654 200 µM -0.535933076670674 0.305589427387605 no 2344 0.29600240172156 3404 1713771 SGTC_741 4582-0002 126 µM -0.536812873132088 0.305295944555826 no 2345 0.2956984393103 3347 2912688 SGTC_74 000s-0487 160.283 µM -0.540151111561584 0.304183512980365 no 2346 0.294546412355109 3417 677548 SGTC_1970 st070122 35.8 µM -0.540346829112902 0.304118348313282 no 2347 0.294478934494987 3496 102928 SGTC_3095 9117207 49.47 µM -0.540596594609286 0.304035197278685 no 2348 0.294392832800432 3399 17015229 SGTC_2071 5230951 39.92 µM -0.541810234708045 0.303631300909208 no 2349 0.293974620029647 3470 1799272 SGTC_329 k048-0121 21.3 µM -0.542563430121488 0.303380759893023 no 2350 0.293715211831196 3421 6832902 SGTC_1275 0867-0008 21.1 µM -0.543327713562212 0.303126625055494 no 2351 0.293452093142363 3315 3422836 SGTC_2765 myclobutanil 7.74 µM -0.543781151520941 0.302975895666533 no 2352 0.293296040374601 3439 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1691 st019933 84.6 µM -0.543804192661674 0.302968237350976 no 2353 0.293288111686578 3414 6176082 SGTC_133 0724-0033 378.92 µM -0.545137479015716 0.302525232988145 no 2354 0.292829483750078 3306 280309 SGTC_2934 9036370 36.88 µM -0.548025642699147 0.301566594635927 no 2355 0.291837147811985 3396 6462800 SGTC_3248 9135562 49.47 µM -0.548117849070124 0.301536012049348 no 2356 0.291805492708759 3423 17650701 SGTC_2315 7733312 200 µM -0.549516752512364 0.301072201452915 no 2357 0.29132543556412 3344 726316 SGTC_118 0083-0097 135.343 µM -0.551601933931691 0.300381450865611 no 2358 0.290610555570544 3517 5207356 SGTC_679 0422-0091 41.4 µM -0.551933411234281 0.300271709561562 no 2359 0.290496988110744 3394 627384 YHR062C RPP1 SGTC_1325 1431-0015 227 µM -0.552091530048241 0.300219367973715 no 2360 0.290442822332045 3351 1103340 SGTC_454 lyso-paf C-16 6.67 µM -0.552157081929874 0.300197669744231 no 2361 0.290420368018022 3392 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2467 5474540 200 µM -0.553462565642609 0.299765691309559 no 2362 0.289973353541955 3395 5413519 SGTC_3334 9142812 21.919 µM -0.553933088850574 0.299610066430045 no 2363 0.289812319448617 3448 45283678 SGTC_721 1187-1332 279 µM -0.554467613258658 0.299433317675469 no 2364 0.28962943219936 3374 25730 SGTC_3159 9100096 49.47 µM -0.555057410398959 0.299238347019073 no 2365 0.28942769630621 3402 25236875 SGTC_1980 st071811 45.7 µM -0.555508484795246 0.299089273157356 no 2366 0.289273454094619 3510 4974850 SGTC_2421 5690543 90.72 µM -0.555913104157672 0.298955580735452 no 2367 0.289135129784989 3443 3397993 SGTC_3144 9087057 49.47 µM -0.556886921986935 0.298633927769631 no 2368 0.288802345261216 3425 17249618 SGTC_1708 st033234 31.827 µM -0.557810426766459 0.29832903871795 no 2369 0.28848692098381 3506 674664 SGTC_1033 k072-0102 21.3 µM -0.558904955603986 0.297967870804247 no 2370 0.288113293584953 3472 5965931 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.561508786259975 0.297109472070609 no 2371 0.287225371166307 3480 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2640 pentamidine 10.38 µM -0.561867483315628 0.296991309919698 no 2372 0.28710315481337 3456 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_10 0279-0212 42.575 µM -0.562959201506532 0.296631807952397 no 2373 0.286731332865459 3446 39851 YBR002C RER2 SGTC_1959 st077091 55.8 µM -0.56398004757066 0.29629582456425 no 2374 0.286383855521597 3416 821356 YKL052C ASK1 SGTC_1117 retinoic acid 1.10837 µM -0.564049160961868 0.296273084102271 no 2375 0.28636033781202 3505 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2614 arthonioic acid 13.39 µM -0.564709024364443 0.296056008769945 no 2376 0.286135847529306 3436 6710684 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.564838877726091 0.29601329949354 no 2377 0.286091680326977 3417 1241132 A phosphatase inhibitor. SGTC_1443 4112-3303 14 µM -0.565374597879359 0.295837128959187 no 2378 0.285909499350598 3447 704433 SGTC_3252 9135871 49.47 µM -0.567724832892986 0.295064828425232 no 2379 0.285110913378824 3491 17682838 SGTC_1038 k292-0204 154 µM -0.570030475124112 0.294308084942017 no 2380 0.284328514280553 3426 4454212 SGTC_1169 aniline yellow 25.8 µM -0.570122345143078 0.294277950515856 no 2381 0.28429736028047 3420 6051 A DNA damaging agent. SGTC_1610 st001799 48.1 µM -0.57054293681374 0.294140009795637 no 2382 0.284154754469007 3371 621897 SGTC_17 0960-0276 49.807 µM -0.571880367370263 0.293701573711296 no 2383 0.283701512741528 3476 6821114 SGTC_2783 7738165 71.43 µM -0.572935919937292 0.293355756489418 no 2384 0.283344041268532 3399 17201110 SGTC_1193 1488-0126 41.5 µM -0.57322424896184 0.293261327748153 no 2385 0.283246433864916 3474 1384710 SGTC_1456 k015-0012 13 µM -0.574081157378035 0.29298077050718 no 2386 0.282956441735797 3551 2989616 SGTC_1527 coumarin 137 µM -0.574390538223348 0.292879507866916 no 2387 0.282851777121674 3504 323 A hepatotoxic, DNA x-linker. SGTC_1183 1254-0324 198 µM -0.575375360191306 0.292557276558797 no 2388 0.282518732287279 3502 5799357 SGTC_2681 menadione 3.18 µM -0.575682359846753 0.292456860724562 no 2389 0.282414950410801 3506 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1523 st012844 44.7 µM -0.576189480201699 0.292291022956262 no 2390 0.282243557485467 3481 4274103 SGTC_2769 toremifene 3.73 µM -0.577563279066037 0.291841985112326 no 2391 0.281779502378236 3534 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_981 1488-1094 54.9 µM -0.578814676617277 0.291433235081097 no 2392 0.281357113491153 3464 3449522 SGTC_2468 5987765 72.9 µM -0.58058384665248 0.290855818640365 no 2393 0.280760480856189 3426 26772094 SGTC_2295 7971645 200 µM -0.58085766199252 0.290766499416259 no 2394 0.280668194426642 3423 2978226 YKL099C UTP11 SGTC_1730 st033808 45.1 µM -0.58258834614319 0.290202243019572 no 2395 0.280085226232344 3381 1045166 SGTC_1337 1486-1011 40.3 µM -0.58302522674941 0.290059887607012 no 2396 0.279938159046072 3509 X1337 SGTC_1313 1220-0047 237 µM -0.585298315114415 0.289319741581225 no 2397 0.279173573790908 3478 3528706 SGTC_1056 3448-1962 115 µM -0.588477592730539 0.28828602031136 no 2398 0.278105884831388 3474 715507 SGTC_513 4245-1575 41.7 µM -0.589041178229181 0.288102956088853 no 2399 0.277916825346392 3471 719745 SGTC_1694 st024011 44.9 µM -0.590052273555572 0.287774668977109 no 2400 0.277577802237872 3550 2787533 SGTC_3016 9080866 49.47 µM -0.592030134104412 0.287132999513548 no 2401 0.276915204870267 3482 17066299 SGTC_2917 7979103 53.79 µM -0.593711049304299 0.286588199894993 no 2402 0.276352695772869 3524 2980565 SGTC_2856 9022925 19.48 µM -0.594046848874729 0.286479423043142 no 2403 0.2762403894879 3489 4944862 SGTC_1347 1493-0251 600 nM -0.594540152411267 0.286319660861031 no 2404 0.27607544751129 3527 3986378 SGTC_3260 9137109 49.47 µM -0.594553516985248 0.286315333174307 no 2405 0.27607097957791 3420 17478346 SGTC_2063 5246145 200 µM -0.595862602282683 0.285891578651604 no 2406 0.275633509185229 3526 711240 SGTC_2434 5670830 169.91 µM -0.59642430547198 0.285709845244448 no 2407 0.275445903652747 3487 1549830 SGTC_1290 0986-0249 10.2 µM -0.596528234462428 0.285676226092678 no 2408 0.275411198874539 3476 53329 SGTC_2112 5488546 200 µM -0.596997385084817 0.285524487767418 no 2409 0.275254563224386 3449 600757 SGTC_1621 st003705 32.4 µM -0.598219575903163 0.28512937240611 no 2410 0.274846715549494 3541 24207032 SGTC_2217 6934799 96.0675 µM -0.598246121280646 0.285120793589255 no 2411 0.274837860606597 3485 675606 SGTC_1371 2421-0008 32.7 µM -0.598727671306693 0.284965189761147 no 2412 0.274677250729608 3477 2827552 SGTC_825 1988-2224 89.6 µM -0.600105223528256 0.284520283467772 no 2413 0.274218055788535 3489 1180859 SGTC_1366 1683-0113 21.9 µM -0.600128276907422 0.284512840770543 no 2414 0.274210374373572 3500 708623 SGTC_1648 st011736 69.8 µM -0.600255059198143 0.28447191124429 no 2415 0.274168132254045 3560 2855514 SGTC_29 0299-0004 12.984 µM -0.600358239112832 0.284438603423609 no 2416 0.274133756494933 3429 16871 A napthoquinone isolated from Swertia calycina. SGTC_2890 9046729 58.44 µM -0.600768445199337 0.284306201986355 no 2417 0.273997111951342 3407 903329 SGTC_2263 7948595 193.29 µM -0.600879539058929 0.284270349502753 no 2418 0.273960111054267 3510 2971371 SGTC_1232 0279-0259 161 µM -0.602729961737861 0.283673494574793 no 2419 0.273344173082014 3511 1560000 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.603076430051828 0.28356180776568 no 2420 0.273228922734144 3637 6728940 SGTC_3249 9135183 49.47 µM -0.603134930600558 0.283542951729135 no 2421 0.273209465296987 3570 4902779 SGTC_2507 purpurin 79.67 µM -0.603494389293899 0.283427103335085 no 2422 0.273089923455964 3420 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1948 st076329 66.6 µM -0.606375433182812 0.282499404772018 no 2423 0.272132739022837 3451 24208413 SGTC_211 3455-0679 143.504 µM -0.606609681747972 0.28242404076633 no 2424 0.272054986760356 3544 748649 SGTC_2476 5806916 10.51 µM -0.606632507790455 0.28241669753727 no 2425 0.272047410884353 3463 2870194 SGTC_1067 clotrimazole 1.36 µM -0.607512380109989 0.282133709114783 no 2426 0.271755464615128 3511 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2309 7664088 163.95 µM -0.608840024358671 0.281706964882591 no 2427 0.271315240617384 3554 704922 SGTC_2075 5212009 200 µM -0.609163893454882 0.281602910985217 no 2428 0.271207905145487 3493 780898 SGTC_2944 9067346 25.62 µM -0.609169113112574 0.281601234145487 no 2429 0.271206175439618 3504 6473075 SGTC_1489 4065-0444 182 µM -0.610660751202735 0.281122235776457 no 2430 0.270712097399449 3518 2877968 SGTC_1108 betulinic acid 729.144 nM -0.611182972424567 0.28095463191604 no 2431 0.270539227377522 3522 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_452 diindolylmethane 8 µM -0.611558931191526 0.280834000044891 no 2432 0.270414808524831 3524 3071 Inhibits expression of several cancer promoting factors. SGTC_2009 4012297 12.05 µM -0.612566458518829 0.280510843694538 no 2433 0.270081521022967 3515 45595307 SGTC_1781 st038725 66.3 µM -0.613681715645186 0.280153343875252 no 2434 0.269712836574391 3503 4270275 YIL048W NEO1 SGTC_2489 cantharidin 73.42 µM -0.613730384076454 0.280137748057376 no 2435 0.269696753386432 3554 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2493 resveratrol 26.09 µM -0.615019031839925 0.279724953499158 no 2436 0.269271075900179 3497 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_653 0203-0016 55.2 µM -0.615352581650094 0.279618155071248 no 2437 0.269160949710681 3516 295302 SGTC_1987 st072290 61.9 µM -0.616055731844319 0.279393080140595 no 2438 0.26892886877623 3481 54697379 SGTC_2954 9074818 52.69 µM -0.616481735368942 0.279256761324421 no 2439 0.2687883114381 3547 16648742 SGTC_2325 6158266 200 µM -0.618383413784615 0.278648629054373 no 2440 0.268161314264154 3516 3623240 SGTC_1913 st060213 96.1 µM -0.618624831874749 0.278571472810649 no 2441 0.268081769651113 3584 688959 SGTC_300 r073-0011 5.04 µM -0.618666780960916 0.278558067113823 no 2442 0.268067949098574 3603 2735780 SGTC_259 usnic acid 108.925 µM -0.618697163575592 0.278548357918048 no 2443 0.268057939461518 3617 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_973 1325-0077 65.9 µM -0.620394444041195 0.278006229826607 no 2444 0.267499064696371 3568 2835149 SGTC_3124 9127567 49.47 µM -0.620434044484645 0.277993587203798 no 2445 0.267486032214248 3537 17592030 SGTC_1000 4048-0884 8.67 µM -0.622197017671846 0.277431034383628 no 2446 0.266906163416967 3558 13040088 SGTC_1673 st016611 27.3 µM -0.62343120557553 0.277037544809759 no 2447 0.266500598405859 3571 5226799 SGTC_2338 7999974 200 µM -0.62465015424248 0.27664918220431 no 2448 0.266100347321246 3608 315925 SGTC_2433 5607874 27.82 µM -0.624700320449681 0.27663320473984 no 2449 0.266083881389111 3553 2252428 SGTC_2098 5376439 882.5 nM -0.625760031489839 0.276295802471807 no 2450 0.265736175631455 3588 2844116 SGTC_969 1313-0238 134 µM -0.626098365221142 0.276188122654188 no 2451 0.265625212215356 3543 5212874 SGTC_496 calpeptin 138 µM -0.626502674238304 0.276059472224455 no 2452 0.265492641689863 3522 73364 A calpain inhibitor. SGTC_627 1391-0720 175 µM -0.630073451260362 0.274924536310864 no 2453 0.26432326434217 3504 997839 SGTC_1045 1348-1485 165 µM -0.630160921210083 0.274896763735455 no 2454 0.26429465214976 3589 6810614 SGTC_1662 st014054 52 µM -0.6320891074445 0.274284896916614 no 2455 0.263664326212171 3557 2838777 SGTC_2736 butenafine 14.65 µM -0.633054317541066 0.273978861823469 no 2456 0.263349086370234 3544 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1385 3091-4834 14.1 µM -0.634354897136289 0.273566759629167 no 2457 0.262924618656155 3544 4072814 SGTC_283 0987-0079 11.7 µM -0.635713323970166 0.27313665571875 no 2458 0.26248164520901 3590 411556 SGTC_3033 9090887 49.47 µM -0.636085231677491 0.273018961084605 no 2459 0.262360435370945 3540 19325384 SGTC_3233 9132340 49.47 µM -0.637792290520514 0.272479064685003 no 2460 0.261804449381139 3508 17682950 SGTC_691 1548-0686 185 µM -0.638412771892672 0.272282954719147 no 2461 0.261602509583677 3542 46495133 SGTC_1832 st054113 55 µM -0.639340704408553 0.271989802364808 no 2462 0.261300657015758 3583 1251267 SGTC_265 mycophenolic acid 32.932 µM -0.640435585844839 0.271644109515266 no 2463 0.260944726910801 3679 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2650 prasterone 100 µM -0.641834858703463 0.271202628172042 no 2464 0.260490206770329 3538 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_716 1683-5115 658 µM -0.642462685821465 0.271004660212182 no 2465 0.260286404803189 3619 723597 SGTC_1031 k035-0009 16 µM -0.645788910724838 0.26995703116412 no 2466 0.259208035308372 3612 5180959 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.646838016770727 0.26962702529036 no 2467 0.258868392470362 3609 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3129 9127257 49.47 µM -0.647131059958934 0.26953488200753 no 2468 0.25877356236116 3475 837894 SGTC_401 neomycin 50 µM -0.647417240066526 0.269444911956095 no 2469 0.258680970530902 3536 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2040 5100729 123 µM -0.647552073260479 0.269402527961392 no 2470 0.258637352017036 3591 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_699 0375-0592 111 µM -0.648386703116941 0.269140241544576 no 2471 0.258367434174218 3623 762578 SGTC_2912 7964298 10.93 µM -0.650411435163223 0.268504492705534 no 2472 0.257713246391044 3609 2975850 SGTC_515 4092-1064 102 µM -0.655076172126423 0.267042683541507 no 2473 0.256209356281513 3639 717353 SGTC_877 0771-0151 33.1 µM -0.655400755003646 0.266941117322013 no 2474 0.256104882761162 3588 6166523 SGTC_2933 9026794 32.47 µM -0.656031259746463 0.266743879938124 no 2475 0.255902005657735 3593 17586027 SGTC_2155 5570423 76 µM -0.656502627853143 0.266596472538851 no 2476 0.255750388651935 3563 797402 SGTC_685 1278-0033 54.9 µM -0.656796993072949 0.266504438817625 no 2477 0.255655728964871 3658 3590572 SGTC_1356 1502-0781 85.8 µM -0.656831206427628 0.266493743004206 no 2478 0.25564472808628 3579 567702 SGTC_821 1114-0266 29.2 µM -0.657027185169943 0.266432480116505 no 2479 0.255581718323603 3601 3123235 SGTC_1733 st037357 54.9 µM -0.659418200773023 0.265685623636902 no 2480 0.254813628819457 3577 1272339 YGL099W LSG1 SGTC_789 1309-1135 70.6 µM -0.659633288817226 0.265618490917187 no 2481 0.254744593253952 3613 3092424 SGTC_868 0527-0199 213 µM -0.659782634409119 0.265571882621207 no 2482 0.254696664424161 3556 2849450 SGTC_1446 4239-0190 62 µM -0.659926176290316 0.265527089477484 no 2483 0.254650602604689 3619 1340085 SGTC_1624 st003710 6.25 µM -0.660697140968879 0.265286570708639 no 2484 0.25440327883924 3620 24207033 SGTC_1960 st011366 51.8 µM -0.660753164673996 0.265269097238118 no 2485 0.254385311466101 3632 3972846 SGTC_415 dibenzyl ketone 100 µM -0.661142119290517 0.265147800648641 no 2486 0.254260588096677 3589 7593 SGTC_1352 1496-0991 99 µM -0.661445059823171 0.26505334730983 no 2487 0.254163468479725 3613 3000039 SGTC_1205 4161-2785 76 µM -0.664480944372841 0.264107738685012 no 2488 0.253191270573312 3588 3498106 SGTC_998 3996-0085 177 µM -0.66559885879943 0.263759967366501 no 2489 0.252833768017342 3637 715391 SGTC_2172 5754775 163.918 µM -0.666757090090116 0.263399900386362 no 2490 0.252463652835316 3549 2263357 SGTC_1348 1493-0373 93.8 µM -0.667509625574489 0.263166089294408 no 2491 0.252223331687212 3618 3010129 SGTC_2700 st077718 96.8 µM -0.667772916926798 0.263084310305885 no 2492 0.252139278460112 3608 904970 SGTC_554 4483-2211 187 µM -0.669197108886635 0.262642177744836 no 2493 0.251684875128191 3610 747107 SGTC_125 0133-0007 11.75 µM -0.671207230543058 0.262018794176872 no 2494 0.251044261555307 3693 26541 SGTC_1322 1348-1070 12 µM -0.671590425582087 0.261900042983358 no 2495 0.250922237601259 3610 6758089 SGTC_217 ketoconazole 989 nM -0.671745625492804 0.261851954769354 no 2496 0.250872824947989 3578 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2321 7390090 138.78 µM -0.672537043226315 0.261606806868076 no 2497 0.250620932953515 3573 649046 SGTC_1280 0880-0253 10.1 µM -0.672676508074337 0.261563618739911 no 2498 0.250576558048245 3613 6836607 SGTC_598 3937-0236 20.2 µM -0.673241873276116 0.261388579398633 no 2499 0.250396712877085 3657 1379313 SGTC_1179 1021-1431 9.29 µM -0.673410879529106 0.261336266064924 no 2500 0.250342964526715 3621 2840958 SGTC_9 0092-0002 10.449 µM -0.674200223230466 0.261092007875561 no 2501 0.250092013869626 3613 759368 SGTC_2419 paclitaxel 166.5 µM -0.675150978259534 0.260797957692303 no 2502 0.249789924077069 3589 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2380 9035439 200 µM -0.677565692418882 0.260051899824454 no 2503 0.249023552427214 3706 6462575 SGTC_1407 3909-7909 12.3 µM -0.678365711866395 0.259804966145981 no 2504 0.248769921861514 3652 4411780 SGTC_1236 0330-0013 258 µM -0.678425489122543 0.25978652018124 no 2505 0.248750976172216 3635 4617066 SGTC_3180 9109287 49.47 µM -0.678587115032401 0.259736649314955 no 2506 0.248699754612494 3628 18891271 SGTC_375 3970-0961 9.27 µM -0.678825011830216 0.259663253493032 no 2507 0.248624371938385 3605 2898222 SGTC_1176 0848-0131 83.3 µM -0.679358656988827 0.259498652460146 no 2508 0.248455319370061 3701 6769040 SGTC_149 3970-0822 46.1 µM -0.679754710983391 0.259376525799483 no 2509 0.248329893692589 3694 3114250 YBL034C STU1 SGTC_1654 st012436 41.8 µM -0.680367939412246 0.259187490129403 no 2510 0.248135758019053 3609 4323132 SGTC_1128 3448-9350 235 µM -0.681070521245914 0.2589709976748 no 2511 0.247913434413286 3641 619386 SGTC_2773 thioridazine 9.09 µM -0.682105362189567 0.25865229384827 no 2512 0.247586165107184 3654 5452 An antipsychotic. SGTC_1782 st039423 80.636 µM -0.682477761124331 0.258537654462805 no 2513 0.24746845012928 3634 2068169 SGTC_2772 vinpocetine 57.06 µM -0.683158585445438 0.258328137375677 no 2514 0.247253319498525 3676 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1278 0874-0585 172 µM -0.68318326020357 0.258320545610527 no 2515 0.247245524510276 3664 766306 SGTC_2247 cerulenin 830 nM -0.685094285220028 0.257732925592356 no 2516 0.246642213104684 3699 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2131 toluylene red 5.2905 µM -0.685115814361239 0.25772630956352 no 2517 0.246635420839956 3642 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2118 5526350 200 µM -0.685565846674656 0.25758803223253 no 2518 0.24649346233119 3650 743594 SGTC_1474 0330-0125 5.35 µM -0.685696423606869 0.257547918260034 no 2519 0.24645228124773 3652 X1474 SGTC_3310 9130229 44.1445 µM -0.685717187087261 0.257541539900352 no 2520 0.246445733243873 3671 7761258 SGTC_1596 piperlongumine 63 µM -0.685916745708747 0.257480241420038 no 2521 0.246382804877018 3668 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_823 0417-1665 178 µM -0.686851218148081 0.25719330012093 no 2522 0.246088245060003 3681 3429856 SGTC_2994 9053520 71.4286 µM -0.687092430141291 0.257119260005619 no 2523 0.24601224208315 3641 4647384 SGTC_1125 tnp00248 1.32998 µM -0.687389576751513 0.257028065977561 no 2524 0.245918632101388 3753 24207736 SGTC_1690 st023502 41.2 µM -0.687967999791973 0.256850596727618 no 2525 0.24573646654822 3630 24207482 SGTC_2611 pyromycin 23.93 µM -0.68931628230104 0.256437170238346 no 2526 0.245312126865182 3644 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_562 3772-2733 112 µM -0.689588092048893 0.256353866702 no 2527 0.245226628977419 3674 2876874 YIL048W NEO1 SGTC_2150 5556613 200 µM -0.689796766882161 0.256289922159545 no 2528 0.245161001080665 3667 743190 SGTC_2753 fluvastatin 17.09 µM -0.69234256862668 0.25551047827388 no 2529 0.244361111583517 3673 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1765 st044815 90.4 µM -0.69356009927431 0.255138147184376 no 2530 0.243979061890604 3660 645695 SGTC_567 1080-0542 68.4 µM -0.694757406926325 0.254772277372033 no 2531 0.243603672470652 3598 5950415 SGTC_839 0122-0028 230 µM -0.695251885753714 0.254621256145478 no 2532 0.243448730592605 3687 759448 SGTC_301 4119-0100 24.5 µM -0.695676386773688 0.254491644601326 no 2533 0.24331575831213 3683 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2086 5274770 176.623 µM -0.695810545050968 0.25445068967201 no 2534 0.243273742238192 3679 689278 SGTC_135 0933-0004 26.348 µM -0.696875565777112 0.254125689941065 no 2535 0.242940335174756 3650 21230617 YGL099W LSG1 SGTC_3042 9091578 49.47 µM -0.697239988287395 0.254014533467079 no 2536 0.242826308703126 3631 25236497 SGTC_3194 9111903 49.47 µM -0.699998129111267 0.253174070802832 no 2537 0.241964236415821 3676 17087251 SGTC_322 k048-0136 19.3 µM -0.701857928097453 0.252608178174862 no 2538 0.241383884290605 3681 6823282 SGTC_1849 st056239 19.2 µM -0.702775062260155 0.252329361547733 no 2539 0.241097970313278 3659 5393181 SGTC_3093 9117344 49.47 µM -0.702822495874834 0.252314945736949 no 2540 0.241083188027565 3682 24824913 SGTC_2502 avocadyne acetate 18.59 µM -0.704805297484398 0.251712730226179 no 2541 0.240465705692162 3654 3952079 SGTC_1284 0929-0043 16 µM -0.705086120784183 0.251627500121236 no 2542 0.240378321632362 3673 1239883 SGTC_2572 astragaloside iv 100 µM -0.706255901288983 0.251272634833258 no 2543 0.240014506064432 3693 45006101 An anti-inflammatory agent. SGTC_2156 5649887 115 µM -0.708250864054734 0.250668052767834 no 2544 0.239394742302906 3741 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3306 9127676 59.7925 µM -0.708696244223043 0.25053318366871 no 2545 0.239256498017756 3688 41905287 SGTC_2541 muurolladie-3-one 83.07 µM -0.709266972357135 0.250360413176357 no 2546 0.239079409984238 3715 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_784 4579-0127 173 µM -0.71013025608434 0.250099200489678 no 2547 0.238811682718974 3795 1948547 SGTC_723 4182-0001 115 µM -0.712461198712283 0.249394625892622 no 2548 0.238089615254856 3668 744821 YLR208W SEC13 SGTC_1995 st072814 61.1 µM -0.71577470698484 0.24839486965776 no 2549 0.237065236284395 3674 5769371 SGTC_1939 st074455 53.6 µM -0.718609527213749 0.247541242346563 no 2550 0.236190770786112 3704 1644229 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.719076451240297 0.247400791641249 no 2551 0.236046907938121 3674 6708514 SGTC_8 0354-0001 70 µM -0.719327795850863 0.247325204842835 no 2552 0.235969486744212 3736 4993152 SGTC_123 0083-0120 66.675 µM -0.71985665519022 0.247166201438142 no 2553 0.235806628936783 3666 16001701 SGTC_2846 9008642 19.48 µM -0.719927126984634 0.247145017975951 no 2554 0.235784932417417 3713 2992898 SGTC_2914 7968218 45.32 µM -0.721732513298501 0.246602659293718 no 2555 0.235229474161763 3677 2977111 SGTC_2159 5658611 73.75 µM -0.722232693825379 0.246452512205117 no 2556 0.235075712906511 3709 793844 SGTC_523 1934-0222 13.7 µM -0.722268479835657 0.246441771631354 no 2557 0.23506471400336 3698 1361595 SGTC_1964 st076914 61 µM -0.722668474213152 0.246321737066933 no 2558 0.234941794265554 3746 24208661 SGTC_3063 1327-0034 4 µM -0.724291850308605 0.245834898991025 no 2559 0.234443289618665 3626 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1896 st058441 89 µM -0.724681011648649 0.245718269275116 no 2560 0.234323873381307 3730 688759 SGTC_2551 apiole 73.87 µM -0.725102373470817 0.245592022741626 no 2561 0.234194614221476 3586 10659 A possible DNA adduct former. SGTC_3160 9100216 49.47 µM -0.726019794376702 0.24531726976803 no 2562 0.233913317973562 3648 17191039 SGTC_1097 itavastatin 7.23 µM -0.727261481069827 0.244945667645978 no 2563 0.233532894856593 3732 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_809 3998-0021 90 µM -0.727634731612644 0.244834023426611 no 2564 0.233418606924862 3646 715485 SGTC_1606 st000094 49.2 µM -0.72854380689306 0.244562221503853 no 2565 0.233140381305187 3731 1242210 SGTC_3208 9114115 49.47 µM -0.729885345256173 0.244161415707297 no 2566 0.232730135399722 3738 650895 SGTC_3060 1327-0027 12.5 µM -0.730254785650617 0.244051101781901 no 2567 0.232617230064389 3665 16000455 YPR107C YTH1 SGTC_2752 diclazuril 33.15 µM -0.731785284943351 0.24359438525018 no 2568 0.232149815972294 3764 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_131 0141-0277 33.849 µM -0.732071104792575 0.243509144882128 no 2569 0.232062584626317 3683 1547771 SGTC_2795 7780010 54.55 µM -0.733710809080283 0.243020445572747 no 2570 0.231562504654259 3729 953673 SGTC_629 3448-6466 76.7 µM -0.734234390064676 0.242864508721725 no 2571 0.231402948601349 3725 573744 SGTC_681 1642-0006 26.6 µM -0.735711862077959 0.242424768936546 no 2572 0.230953034587527 3741 4446530 SGTC_1967 st070177 51.4 µM -0.737047536455933 0.242027603896897 no 2573 0.230546720897279 3768 5729214 SGTC_364 0083-0097 67.7 µM -0.737238231747754 0.241970929129897 no 2574 0.230488743775904 3793 5207356 SGTC_251 melphalan 456.522 µM -0.737381973942235 0.241928213613097 no 2575 0.230445047199693 3799 460612 A DNA alkylator. SGTC_2143 5623677 140.463 µM -0.738548441553463 0.241581728618528 no 2576 0.230090620893863 3696 5375313 SGTC_77 0828-0286 12.516 µM -0.739259563095883 0.24137063090116 no 2577 0.229874699320421 3704 745345 SGTC_2587 piperic acid 92.2 µM -0.739440001637648 0.241317083338048 no 2578 0.229819929865489 3744 5370536 SGTC_2254 7938975 95.19 µM -0.739518170904382 0.241293887561285 no 2579 0.229796205007258 3772 2969277 SGTC_2760 etidronate 98.04 µM -0.74106059335471 0.240836440413413 no 2580 0.229328350803689 3741 3305 A chelator and antioxidant. SGTC_3157 9099274 49.47 µM -0.741122373396803 0.240818127701873 no 2581 0.229309622545016 3698 17217662 SGTC_903 1134-0042 114 µM -0.742119487369106 0.240522670070164 no 2582 0.229007471897861 3741 701009 SGTC_1947 st076332 61.6 µM -0.742711629971699 0.240347304096976 no 2583 0.228828143541586 3712 24208416 SGTC_2192 5915882 198.485 µM -0.744773982836187 0.239737072181417 no 2584 0.228204182780324 3714 2876149 SGTC_3207 9114163 49.47 µM -0.744805828486899 0.239727655968575 no 2585 0.22819455544692 3760 849233 SGTC_968 1309-0633 340 µM -0.746562535012638 0.239208540721455 no 2586 0.227663835219858 3736 3761976 SGTC_3174 9107204 49.47 µM -0.746882516701009 0.239114050765381 no 2587 0.227567240124241 3753 3938802 SGTC_2004 4023728 41.89 µM -0.747834272241689 0.238833119866495 no 2588 0.227280063517198 3735 360084 YDR527W RBA50 SGTC_2271 7849410 118.62 µM -0.748371597754594 0.238674596575377 no 2589 0.227118024599195 3712 972430 SGTC_1158 4092-0494 91.8 µM -0.748761600864976 0.238559572826046 no 2590 0.227000453858412 3868 1148199 SGTC_1944 st076371 56.9 µM -0.748806945435973 0.238546201305636 no 2591 0.226986786464648 3763 24208455 SGTC_2842 9000675 19.48 µM -0.750511218930657 0.238043930958806 no 2592 0.226473434736516 3748 2989072 SGTC_379 3970-0972 5.9 µM -0.751070851167012 0.237879126970917 no 2593 0.226305008528517 3762 2898042 YBL034C STU1 SGTC_672 1441-0018 53.7 µM -0.752047233560958 0.237591745661492 no 2594 0.226011327201081 3751 251141 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.754961992989272 0.236734970944228 no 2595 0.22513589362498 3771 5106787 A p450 inhibitor. SGTC_1065 prochlorperazine maleate 2.48 µM -0.755703966935599 0.236517144144814 no 2596 0.224913352563309 3805 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3101 9120531 49.47 µM -0.756440476728638 0.236301030625656 no 2597 0.224692573742988 3788 24824904 SGTC_943 3253-1379 105 µM -0.75680353746365 0.23619453800857 no 2598 0.224583786598737 3748 668464 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.757371635837043 0.236027957007088 no 2599 0.224413622160982 3589 88881 An O-methylated flavonoid and antioxidant. SGTC_803 4488-1585 147 µM -0.757834673587464 0.235892230371949 no 2600 0.224274981033458 3781 747204 SGTC_204 PMA1.184 62.41 µM -0.758640030391085 0.235656264949676 no 2601 0.224033959825881 3803 2252213 YGL008C PMA1 SGTC_1994 st072947 40.9 µM -0.758981504626366 0.235556254062438 no 2602 0.223931810389394 3815 5286565 YDL195W SEC31 SGTC_2278 7948257 134.34 µM -0.759190319749739 0.23549510788184 no 2603 0.223869357966178 3732 1247028 SGTC_3025 9087895 49.47 µM -0.759207214461681 0.235490161079541 no 2604 0.223864305528917 3782 17173641 SGTC_151 3013-0144 2.285 µM -0.761855258111639 0.234715518294147 no 2605 0.22307319802771 3754 906558 YHR107C CDC12 SGTC_1878 temozolomide 1 mM -0.763701158651296 0.234176364090448 no 2606 0.222522675077744 3697 5394 DNA alkylating agent. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.76506299048622 0.233779037576356 no 2607 0.222117018283968 3778 3256 An antibiotic and ribosome inhibitor. SGTC_590 k048-0076 22.4 µM -0.766096535282443 0.233477741280389 no 2608 0.221809432203646 3770 6832814 SGTC_2113 5491891 107.031 µM -0.766463789289745 0.233370732233598 no 2609 0.221700194907198 3797 789979 SGTC_2313 7726885 200 µM -0.766639303703059 0.233319601136817 no 2610 0.221648000152965 3793 726423 SGTC_3116 9124943 49.47 µM -0.768880532659759 0.232667230080804 no 2611 0.220982117558328 3737 41905195 YPL160W CDC60 SGTC_2844 9010103 25.97 µM -0.770362824836735 0.232236325984287 no 2612 0.220542349432103 3827 2480525 SGTC_3127 9126946 49.47 µM -0.771765416375499 0.23182900018835 no 2613 0.220126689108024 3784 27243249 SGTC_323 4013-0906 34.3 µM -0.771849299609696 0.231804652325211 no 2614 0.220101844420934 3824 2910086 SGTC_2487 5918373 44.05 µM -0.772601947528232 0.231586253241478 no 2615 0.219878995780802 3801 2876279 SGTC_172 1112-0046 2.638 µM -0.772762089422036 0.231539798981529 no 2616 0.219831596693465 3760 2802135 YIL048W NEO1 SGTC_2090 5301565 104.445 µM -0.773404864628264 0.231353393825422 no 2617 0.219641405948346 3798 2056344 SGTC_1024 4507-0395 26 µM -0.773866478666859 0.231219577158451 no 2618 0.219504877293987 3856 4201836 SGTC_600 1495-0418 41.6 µM -0.774517429617973 0.231030947274809 no 2619 0.219312432531534 3791 5377768 SGTC_1300 1094-0077 113 µM -0.7748686266524 0.230929214528071 no 2620 0.219208646204446 3752 5532636 SGTC_2114 5491910 81.25 µM -0.775618994318293 0.230711936148869 no 2621 0.218986990946625 3864 2849228 SGTC_1391 3442-0225 151 µM -0.776110824083755 0.23056958264668 no 2622 0.218841776595337 3745 5227075 SGTC_1259 0671-0132 43 µM -0.777017455513455 0.230307299072531 no 2623 0.218574235942729 3755 X1259 SGTC_1609 st001574 46.4 µM -0.777809152366286 0.230078401974614 no 2624 0.218340765778913 3805 3960012 SGTC_2296 7971656 126.45 µM -0.780867447800526 0.229195377678025 no 2625 0.217440229714715 3870 666570 SGTC_279 1273-0055 2.93 µM -0.783998056785047 0.22829344601841 no 2626 0.216520625265709 3825 2847562 SGTC_1388 3346-4487 254 µM -0.784109085563504 0.228261495186187 no 2627 0.216488052357757 3863 3345614 SGTC_150 3970-0969 77.2 µM -0.785597616599443 0.227833382353234 no 2628 0.216051630617185 3903 6615640 SGTC_2222 6885208 172.143 µM -0.786111113402361 0.227685801657655 no 2629 0.215901197027179 3764 609514 SGTC_2116 5511452 16.8835 µM -0.78726697866366 0.227353799103216 no 2630 0.215562797881049 3856 870744 SGTC_406 estrone 100 µM -0.788007473260581 0.227141248096171 no 2631 0.215346167281788 3794 5870 A steroid. SGTC_2923 7992654 58.14 µM -0.788165849644093 0.227095802404374 no 2632 0.215299850907834 3846 2985126 SGTC_495 decylubiquinone 155 µM -0.789750910142409 0.226641255888851 no 2633 0.214836626499664 3828 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2873 9040596 71.43 µM -0.790986382668694 0.226287316830512 no 2634 0.214475968935446 3778 6463863 SGTC_3281 9140613 49.47 µM -0.791190496918112 0.226228872102841 no 2635 0.214416418066379 3813 16013766 SGTC_487 nimodipine 119 µM -0.792415574362177 0.225878270767805 no 2636 0.214059200594776 3689 4497 L-type voltage-gated calcium channels inhibitor SGTC_2199 6590217 200 µM -0.794408695315398 0.225308522424415 no 2637 0.213478771873552 3742 703109 SGTC_2479 5617353 43.85 µM -0.795140996437594 0.22509939335412 no 2638 0.213265744700788 3844 2731746 SGTC_2569 tetrandrine 100 µM -0.796584853578706 0.22468738192696 no 2639 0.212846088452769 3850 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3251 9135047 49.47 µM -0.797321553188911 0.224477326128981 no 2640 0.212632152971764 3834 17682963 SGTC_1111 tnp00062 510.699 nM -0.798427090666599 0.224162312460295 no 2641 0.212311343746597 3895 676306 SGTC_2885 9057732 51.95 µM -0.799507686068926 0.22385464859355 no 2642 0.211998045853826 3849 6471414 SGTC_1496 4469-0713 57.4 µM -0.7997280715932 0.223791930568474 no 2643 0.211934182513957 3783 746691 SGTC_727 3032-0951 202 µM -0.799908957958473 0.223740460806134 no 2644 0.211881773654221 3829 3652836 SGTC_1370 2001-0092 44.6 µM -0.800786218934829 0.223490938723375 no 2645 0.211627709235794 3885 790957 SGTC_2345 9052315 157.45 µM -0.801327651815823 0.223337016307654 no 2646 0.211470993358959 3874 6469265 SGTC_2868 9035608 32.47 µM -0.801661923298601 0.223242017344562 no 2647 0.211374273572024 3805 6462614 SGTC_726 3448-4391 34.2 µM -0.801994859307995 0.223147420786383 no 2648 0.211277965957347 3914 1356692 SGTC_1704 st028805 70.8 µM -0.802079764683347 0.223123300414953 no 2649 0.211253409694021 3858 2876101 SGTC_860 0443-0016 25.1 µM -0.802442948115115 0.223020142087679 no 2650 0.211148388954368 3856 5337942 SGTC_886 0866-0150 153 µM -0.80246602586114 0.223013588021377 no 2651 0.211141716660943 3872 271463 SGTC_1432 4049-0298 68.4 µM -0.803162756711829 0.222815768524204 no 2652 0.21094033434548 3843 741646 SGTC_3080 9117754 49.47 µM -0.803765800271322 0.222644629967253 no 2653 0.210766122254591 3855 9550191 SGTC_2080 5212524 12.4 µM -0.804668967175648 0.222388459195653 no 2654 0.210505366014705 3762 260183 SGTC_2178 5812956 200 µM -0.805048059375873 0.222280985062259 no 2655 0.210395973518263 3825 5403383 SGTC_1224 0823-0416 294 µM -0.806063121657436 0.221993356856071 no 2656 0.210103227091174 3915 3598164 SGTC_644 1498-1197 63.3 µM -0.807813167932726 0.221497962820558 no 2657 0.20959907179542 3912 6741615 SGTC_3178 9107506 49.47 µM -0.808506536671838 0.221301862517854 no 2658 0.209399522313518 3880 8897194 SGTC_2741 miltefosine 3.04 µM -0.809834810769909 0.220926474114449 no 2659 0.209017561294211 3791 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_985 1493-0307 8.71 µM -0.811409404265699 0.220481945023635 no 2660 0.208565300156724 3852 3278274 SGTC_2627 acetyl isogambogic acid 100 µM -0.812664902353691 0.220127868480754 no 2661 0.208205104659845 3861 6857789 A caspase activator and apoptosis inducer. SGTC_424 splitomicin 100 mM -0.812951846308855 0.220046990136118 no 2662 0.208122833579117 3948 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_476 mead acid 10 µM -0.812993639701377 0.220035211626152 no 2663 0.208110852395589 3858 5312531 An omega 9 fatty acid. SGTC_2606 farnesol 9.78 µM -0.813278275987152 0.219955003032359 no 2664 0.208029264688871 3864 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1491 4138-0063 26.5 µM -0.813393504303723 0.219922537237858 no 2665 0.207996241191384 3795 23883227 SGTC_212 3807-4682 38.772 µM -0.813857159207894 0.219791929395983 no 2666 0.207863392754245 3932 3125501 YBL034C STU1 SGTC_1100 amiodarone 5.07 µM -0.81551113736613 0.21932637998802 no 2667 0.207389896042607 3936 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1877 wortmannin 25 µM -0.816857594022899 0.218947808234611 no 2668 0.207004907064972 3859 312145 A covalent inhibitor of PI 3-kinase. SGTC_57 miconazole 162.5 nM -0.817289137374983 0.218826554449825 no 2669 0.206881606499593 3800 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3351 9150312 21.596 µM -0.81733011006403 0.218815044072582 no 2670 0.206869902042935 3810 4904905 SGTC_1698 5-fluorocytosine 1.055 µM -0.817553878133535 0.218752187494442 no 2671 0.206805986289048 3890 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_205 1486-1330 71.903 µM -0.818821475777558 0.218396314806871 no 2672 0.20644413812898 3844 4118834 SGTC_1919 st067113 52.3 µM -0.818911121109949 0.218371159889796 no 2673 0.206418562201067 3908 1268243 SGTC_3153 9100258 49.47 µM -0.821396916735423 0.217674298580281 no 2674 0.20571010961619 3791 25236848 SGTC_1924 st058459 75.1 µM -0.821439625246463 0.217662337013105 no 2675 0.205697950299266 3794 688683 SGTC_419 nsc-638432 893 µM -0.82206789752502 0.217486417767826 no 2676 0.205519127480494 3833 368090 SGTC_2597 laccaic acid a 100 µM -0.823734969020499 0.217020027789276 no 2677 0.205045082688308 3882 5491415 A textile dye. SGTC_3188 9110789 49.47 µM -0.824519752716362 0.216800672211814 no 2678 0.204822148493306 3848 849217 SGTC_2463 5473429 200 µM -0.824743411702023 0.216738180575008 no 2679 0.204758639892064 3870 5399405 SGTC_2602 kawain 100 µM -0.826833917000736 0.216154585001829 no 2680 0.204165601561529 3816 5369129 SGTC_256 clotrimazole 625 nM -0.829810184533293 0.215325287811263 no 2681 0.20332305583998 3812 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1557 sumaresinolic acid 42.3 µM -0.830853973826503 0.215034887709683 no 2682 0.203028063705417 3827 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1085 doxorubicin 7.67 µM -0.831513771061946 0.214851438161098 no 2683 0.202841725987499 3873 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_491 tetrandrine 80.3 µM -0.831531360428482 0.214846548870747 no 2684 0.202836759856214 3880 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_199 4063-0024 41.6 µM -0.831844873189524 0.214759413033297 no 2685 0.2027482557483 3890 306215 SGTC_2646 retinol 96.75 µM -0.832235656265499 0.214650829906691 no 2686 0.202637970676325 3862 445354 A vitamin A analog and teratogen. SGTC_3177 9107506 49.47 µM -0.836477782523625 0.213474165964699 no 2687 0.201443085264757 3793 8897194 SGTC_1888 azatryptophan 97.5 µM -0.837990254304464 0.213055553431435 no 2688 0.201018088494316 3935 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2395 5646831 180.19 µM -0.839700342819138 0.212582823097844 no 2689 0.200538210868899 3903 6808628 SGTC_2057 5236571 38.335 µM -0.840296226978698 0.212418243191113 no 2690 0.200371158192846 3872 54684039 YBR257W POP4 SGTC_3263 9137018 49.47 µM -0.840356780479735 0.212401522817284 no 2691 0.200354187049709 3907 43844957 SGTC_1189 1431-2119 7.28 µM -0.841082120681243 0.212201297579013 no 2692 0.200150965319228 3905 3107275 SGTC_1167 k781-0610 148 µM -0.841232043138485 0.212159926266539 no 2693 0.200108976345354 3913 4525169 SGTC_893 0958-0369 48.9 µM -0.841316189767285 0.212136707952473 no 2694 0.200085411611758 3880 6819948 SGTC_2253 7938677 135.83 µM -0.841509886977708 0.212083267337839 no 2695 0.200031174267234 3973 2301972 SGTC_2402 5553605 200 µM -0.842238181117252 0.211882403117465 no 2696 0.199827323025595 3950 6758546 SGTC_1244 0416-0015 52.5 µM -0.844561129902383 0.211242475678702 no 2697 0.199177959560834 3884 96201 SGTC_2724 maprotiline 69.64 µM -0.845898397953751 0.210874598353729 no 2698 0.198804713152835 3824 4011 A tricyclic antidepressant. SGTC_1046 2001-0062 216 µM -0.846548905107341 0.210695782232046 no 2699 0.198623301908433 3806 739778 SGTC_2341 7987486 176.74 µM -0.84752816746024 0.210426763312818 no 2700 0.198350396866849 3933 1258686 SGTC_2785 7756463 72.73 µM -0.848350301435706 0.210201065831583 no 2701 0.198121455860725 3868 2201551 SGTC_2432 5630864 12.22 µM -0.849003119340337 0.210021951396073 no 2702 0.197939778274262 3946 5714970 SGTC_2565 isoliquiritigenin 100 µM -0.849970115067094 0.209756800480689 no 2703 0.197670850787878 3992 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2999 9069765 71.4286 µM -0.850087081878481 0.209724741446231 no 2704 0.19763833657254 3916 2097066 SGTC_2495 cafestol 54.53 µM -0.850875442350203 0.209508737573872 no 2705 0.197419273934425 3918 16667697 An anti-infammatory. SGTC_1861 st057647 17.4 µM -0.851822516887571 0.209249420562587 no 2706 0.197156303472712 3995 688668 SGTC_170 4197-0004 226 µM -0.852011775309178 0.209197622666739 no 2707 0.19710377825216 3945 218692 SGTC_864 0469-0573 172 µM -0.852161965254086 0.209156522744898 no 2708 0.197062101801301 3884 689425 SGTC_3286 9117135 37.221 µM -0.852357438164943 0.209103038126573 no 2709 0.197007867695265 3870 3438150 SGTC_1981 st071826 47 µM -0.854744469430932 0.208450556836571 no 2710 0.196346313100655 3931 11838600 SGTC_1386 3228-0095 33.8 µM -0.854779279621212 0.208441050562061 no 2711 0.196336675591356 3933 870181 SGTC_3117 9124945 49.47 µM -0.856893989172145 0.207864026670644 no 2712 0.195751737509622 3829 17592065 SGTC_1211 1056-0033 32.3 µM -0.857205358974113 0.207779145424205 no 2713 0.195665700661291 3929 6741922 SGTC_2859 9028643 45.46 µM -0.857521221295601 0.207693060411858 no 2714 0.195578445912482 3822 17151580 SGTC_2045 5106652 78.05 µM -0.858552800616541 0.20741206094153 no 2715 0.19529364399074 3886 673349 SGTC_1411 3909-8223 150 µM -0.859506686937911 0.207152424939256 no 2716 0.195030516173595 3914 X1411 SGTC_3004 9076122 71.4286 µM -0.863972757241604 0.205939375717336 no 2717 0.193801428120884 3954 44782551 SGTC_1342 1486-1464 234 µM -0.864494271923788 0.205798000052721 no 2718 0.193658212818669 3938 3253938 SGTC_1030 k029-0042 36.7 µM -0.864962337145919 0.205671162873039 no 2719 0.193529730461849 3912 6080581 SGTC_1419 3993-2473 62.6 µM -0.867446541484271 0.204998765577655 no 2720 0.192848695231049 3994 704026 SGTC_912 3474-0017 2.18 µM -0.867848908893736 0.204889980262735 no 2721 0.192738525652407 3974 3360550 SGTC_3200 9114385 49.47 µM -0.867867185837096 0.204885039666134 no 2722 0.192733522275772 3981 17018030 YLR208W SEC13 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.870004790717491 0.204307694205644 no 2723 0.19214889306955 3889 4330530 SGTC_1988 st071872 53.4 µM -0.870990583512623 0.204041768224705 no 2724 0.191879647319652 3956 16414116 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.87157256496727 0.203884870634044 no 2725 0.1917208014665 3970 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1022 4477-0945 21.3 µM -0.872175372342822 0.20372243437053 no 2726 0.19155635632032 3881 4648966 SGTC_1625 st003711 30.1 µM -0.872947464592333 0.20351449427814 no 2727 0.191345856713888 3997 24207034 YER133W GLC7 SGTC_1848 st056003 16.4 µM -0.876638613568409 0.202522143699281 no 2728 0.190341479473495 3963 146492 SGTC_346 4513-0042 7.16 µM -0.876999858846435 0.202425180007596 no 2729 0.190243357370978 3933 2827372 SGTC_2616 abietic acid 100 µM -0.877456016293248 0.202302780121425 no 2730 0.190119499455515 3951 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2257 7960413 200 µM -0.877934344314229 0.202174478804739 no 2731 0.189989674923713 3930 2974689 YIL048W NEO1 SGTC_1490 4089-0339 670 nM -0.881234708731496 0.201290553796097 no 2732 0.189095398375613 3875 742542 SGTC_2927 9011802 47.9 µM -0.88168951003758 0.201168927848808 no 2733 0.188972367619553 3968 43912568 SGTC_1012 4112-3522 18 µM -0.882185140304094 0.201036433346343 no 2734 0.188838348166682 3960 3112398 SGTC_988 1497-1057 103 µM -0.882621106146844 0.200919931935628 no 2735 0.188720510528771 3864 3533044 SGTC_853 0419-0306 21 µM -0.883516429815462 0.20068080521822 no 2736 0.18847865476554 3961 762713 SGTC_545 4218-0007 221 µM -0.883548979548228 0.200672114921871 no 2737 0.188469865636642 3952 2840508 SGTC_824 1304-0008 100 µM -0.884614991446709 0.200387630414585 no 2738 0.18818215917085 3963 768245 SGTC_1328 1441-0025 69.2 µM -0.885183880781505 0.200235911226269 no 2739 0.188028732324508 3902 4562601 SGTC_3149 9097855 49.47 µM -0.885448546105731 0.200165350191518 no 2740 0.187957379625735 3966 25236625 YMR079W SEC14 SGTC_1062 mesoridazine 14.2 µM -0.885637815288488 0.200114899292841 no 2741 0.187906363674496 3957 4078 A neuroleptic. SGTC_1072 oxiconazole 14.9 nM -0.88569611946056 0.20009935948678 no 2742 0.187890649987258 3942 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2608 thymoquinone 42.66 µM -0.886319068105199 0.199933370319999 no 2743 0.187722808363637 3945 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1007 4101-0031 70 µM -0.886439340750131 0.199901332343729 no 2744 0.187690413864575 3914 1146276 SGTC_1635 st007035 42.4 µM -0.89013695504263 0.198917876748357 no 2745 0.186696175944095 3933 3716403 SGTC_1381 2324-0066 62.1 µM -0.893293483578938 0.198080645490655 no 2746 0.185850013374459 4019 10885928 SGTC_1619 st003326 88.7 µM -0.893535778928485 0.198016467615528 no 2747 0.185785160317452 3945 2849032 SGTC_2448 5185112 27.17 µM -0.895016238478678 0.197624604384405 no 2748 0.185389203767028 4001 5718189 SGTC_1940 st075990 51.1 µM -0.896294487663709 0.197286641628582 no 2749 0.185047751196031 4081 1084979 SGTC_618 k072-0232 33.2 µM -0.897140872097899 0.197063054282239 no 2750 0.184821875725384 4019 5872756 YGL099W LSG1 SGTC_247 mechlorethamine 29.705 µM -0.897883047295423 0.196867121890642 no 2751 0.184623951761928 3863 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_235 0330-0087 5 mM -0.898471821904036 0.196711770802507 no 2752 0.18446703059551 3975 46494818 YHR062C RPP1 SGTC_111 0083-0039 52.457 µM -0.899009682960833 0.196569918423 no 2753 0.184323751526146 3859 759313 SGTC_2013 4024628 200 µM -0.899921464682495 0.196329591985368 no 2754 0.184081023174862 4015 5230760 SGTC_2144 5628481 200 µM -0.900319711013051 0.196224678561193 no 2755 0.183975067201304 3962 2818399 SGTC_595 3909-8003 73.7 µM -0.901037699798215 0.196035618565618 no 2756 0.183784137682789 4041 699517 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.901944599257693 0.195796972814651 no 2757 0.18354314901555 4000 368090 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.902476090383149 0.195657195743326 no 2758 0.183402008464206 3976 165521 SGTC_2797 7859098 81.82 µM -0.9027256698988 0.195591579630995 no 2759 0.183335754529405 3967 972681 SGTC_61 0978-8327 98.565 µM -0.903713761289022 0.195331935028213 no 2760 0.183073600107773 3913 6150059 YHR072W ERG7 SGTC_3128 9127691 49.47 µM -0.905976622467533 0.194738103640079 no 2761 0.182474113091143 4036 41316314 SGTC_2931 9014674 55.67 µM -0.907156777282547 0.194428837702571 no 2762 0.18216194844088 3977 2996810 SGTC_1064 honokiol 6.76 µM -0.908391037840458 0.19410571312409 no 2763 0.181835829536178 3986 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3133 9127736 49.47 µM -0.908592288846729 0.194053057435123 no 2764 0.181782689223109 3919 27243420 SGTC_551 k048-0028 34.9 µM -0.909196769305184 0.193894952372722 no 2765 0.181623134624545 3984 6836383 SGTC_569 4130-2812 160 µM -0.910166534244215 0.193641469286383 no 2766 0.18136734513046 3796 743552 SGTC_3345 9148410 3.559 µM -0.910464948554596 0.193563508607552 no 2767 0.181288679455026 3953 4903596 SGTC_210 3551-0445 56.827 µM -0.911111085182123 0.193394771154336 no 2768 0.181118423139978 4017 2865180 YOR207C RET1 SGTC_3073 9114972 49.47 µM -0.91136365711058 0.193328836840911 no 2769 0.181051897943761 3968 41905075 SGTC_1885 st057546 99.9 µM -0.911592638777237 0.193269072660563 no 2770 0.180991599445352 4037 702008 SGTC_634 1611-4317 11.2 µM -0.915325383327691 0.192296417646896 no 2771 0.180010418654788 3977 2843522 SGTC_378 3970-0959 8.33 µM -0.91575536426699 0.192184568541954 no 2772 0.179897609752378 4014 6615653 SGTC_2519 cryptotanshinone 88.04 µM -0.916297396696367 0.19204362868225 no 2773 0.179755466533581 3977 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3094 9117742 49.47 µM -0.919189817057522 0.191292608225634 no 2774 0.178998148208579 3919 17149698 SGTC_2539 epi(13)torulosol 80 µM -0.919566337243597 0.191194976898838 no 2775 0.178899712355093 4041 6708597 SGTC_1875 nocodazole 6 µM -0.921234351075198 0.190762830045283 no 2776 0.178464043726805 3990 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2879 9041815 71.43 µM -0.921284401910261 0.190749872209421 no 2777 0.178450981282871 4005 4942971 SGTC_2998 9066762 71.4286 µM -0.922370504346463 0.190468820397218 no 2778 0.178167674782121 4032 4945196 SGTC_2350 9023895 38.85 µM -0.923184518906975 0.190258343832915 no 2779 0.177955527545035 4023 2997209 SGTC_1746 st038117 42 µM -0.923333418325487 0.19021985895635 no 2780 0.177916738846103 4069 2898218 SGTC_325 2810-4341 181 µM -0.924133151733427 0.190013239910274 no 2781 0.177708497379397 4003 774970 SGTC_2742 clothiapine 36.27 µM -0.925440398686133 0.189675796889011 no 2782 0.177368436448975 3956 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1450 4112-4260 37.6 µM -0.925910414858768 0.189554560551383 no 2783 0.17724626918889 3977 1633175 SGTC_1568 digitonin 820 nM -0.926208872853364 0.1894776008194 no 2784 0.177168721162825 3981 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3068 9116768 49.47 µM -0.926652708942757 0.189363189770124 no 2785 0.17705343933735 3971 41904888 SGTC_276 colchicine 750 µM -0.926668980191134 0.189358996213217 no 2786 0.177049213949931 4084 2833 A microtubule depolymerizer. SGTC_3305 9127027 53.8275 µM -0.927182987623022 0.189226551513166 no 2787 0.176915767096131 3931 41905295 SGTC_407 eburnamonine 100 µM -0.929316524394733 0.188677411371906 no 2788 0.176362537015687 3863 3195 SGTC_1135 dihydrocapsaicin 536.708 nM -0.929652676596783 0.18859098054069 no 2789 0.176275472039331 3923 107982 A Capsaicinoid. SGTC_236 1509-0011 5.31 µM -0.931789682574142 0.188042088579159 no 2790 0.175722613846207 4062 3107280 SGTC_1965 Pectolinarigenin 58.4 µM -0.933425032330961 0.187622714262397 no 2791 0.175300280387002 3992 5320438 An anti-inflammatory. SGTC_2953 9074162 66.49 µM -0.934225512741087 0.187417647327933 no 2792 0.175093788999679 3991 16451992 SGTC_1294 1000-1494 117 µM -0.934574403123683 0.187328312015966 no 2793 0.175003837772037 4002 712797 YDL207W GLE1 SGTC_2393 9031399 185.94 µM -0.934816400296759 0.187266362767052 no 2794 0.174941463070812 4073 1526623 YDL150W RPC53 SGTC_408 cantharidin 100 µM -0.936849708425201 0.186746353393168 no 2795 0.174417935833531 3974 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1001 4048-4355 44.4 µM -0.937990518037148 0.186454988303349 no 2796 0.174124641486794 3994 21824233 SGTC_1668 st014914 51.6 µM -0.938330331523106 0.186368253705546 no 2797 0.174037338395582 4011 2839556 SGTC_974 1326-0144 138 µM -0.93937733006487 0.186101173120706 no 2798 0.173768524037777 4042 5411856 SGTC_1571 st070080 73.4 µM -0.939792324786433 0.185995377120781 no 2799 0.173662048268258 4068 4315245 SGTC_1367 1812-0510 76.9 µM -0.940689645617556 0.185766747617962 no 2800 0.173431963366899 4049 1142582 YDR527W RBA50 SGTC_2439 5492030 7.2 µM -0.941432332846832 0.185577649318267 no 2801 0.173241675394113 3995 5722370 SGTC_1565 sinapyl alcohol 95.1 µM -0.945782745437388 0.18447237560161 no 2802 0.172129703994855 4071 5280507 A phenol propionate derived from cinnamic acid. SGTC_926 2268-1401 59.4 µM -0.946603287099605 0.18426436720541 no 2803 0.171920484160602 3986 2931578 SGTC_602 3130-1533 38.1 µM -0.946822773189118 0.184208751943597 no 2804 0.171864547636881 4059 720941 SGTC_3327 9140648 26.9345 µM -0.947294816901299 0.184089176871637 no 2805 0.17174428561512 4049 8029710 SGTC_3056 9094900 49.47 µM -0.947845508705962 0.183949740253401 no 2806 0.171604054459405 4007 25236784 SGTC_3107 9121808 49.47 µM -0.948203762186392 0.183859064845697 no 2807 0.171512866132603 3913 662681 SGTC_582 0987-0078 156 µM -0.949134254084379 0.183623683656248 no 2808 0.171276167346385 4063 1625765 SGTC_1871 st057448 67.3 µM -0.951379615443334 0.183056461208326 no 2809 0.170705852212637 4076 691747 SGTC_65 0798-0905 34.986 µM -0.951722187527522 0.182970016975222 no 2810 0.170618946913719 4134 3602145 SGTC_2318 6029776 164 µM -0.952394502175465 0.182800439960331 no 2811 0.170448473325643 4062 818325 SGTC_1926 methyl fluorone black 53.6 µM -0.952534488039758 0.182765143859055 no 2812 0.170412991925921 3777 72721 Reacts with homocysteine. SGTC_2671 danthron 100 µM -0.95264843342081 0.182736416758599 no 2813 0.170384114348066 4025 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1143 3454-2408 5.08 µM -0.95370463550329 0.182470268774337 no 2814 0.170116586538597 3988 X1143 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.954529009353626 0.182262706565628 no 2815 0.169907966179255 3844 4000243 SGTC_829 1635-0120 117 µM -0.958171273853613 0.181347418351635 no 2816 0.168988199980923 4060 285054 SGTC_1309 pyrazolanthrone 13.4 µM -0.959204337386256 0.181088337947473 no 2817 0.168727907928504 4032 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2078 5212016 200 µM -0.959977977952282 0.180894469754727 no 2818 0.168533149249105 3893 1899708 SGTC_2200 6600604 21.907 µM -0.96331701673862 0.180059226196065 no 2819 0.167694228088888 4021 2904777 SGTC_519 k048-0011 62.8 µM -0.966408005209903 0.179288193026399 no 2820 0.166920029961689 4097 6836379 SGTC_936 3005-4620 401 µM -0.966639402337124 0.17923055570816 no 2821 0.16686216495473 4095 777207 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.967495400898063 0.179017441483687 no 2822 0.1666482196322 4121 1273210 SGTC_836 0330-0104 1.35 µM -0.968539991682476 0.178757590380909 no 2823 0.16638737816234 4059 46494820 SGTC_3021 9087658 49.47 µM -0.968611444411157 0.178739824570189 no 2824 0.166369545564894 4022 25237042 SGTC_2798 7813637 45.45 µM -0.968742699650328 0.178707192523699 no 2825 0.166336791153568 4076 956368 SGTC_1661 st013063 9.66 µM -0.969637189378236 0.178484908683055 no 2826 0.166113684413988 4096 721395 SGTC_1027 k015-0025 8.67 µM -0.971607990058127 0.177995772692844 no 2827 0.16562280302553 4027 3598955 SGTC_2273 7815444 169.05 µM -0.97250034648567 0.177774575674833 no 2828 0.165400846296819 4018 2824616 SGTC_2336 9001819 198.65 µM -0.972905513102392 0.177674200373582 no 2829 0.165300132343494 4129 2989602 SGTC_3048 9093155 49.47 µM -0.974130178709937 0.177371021214513 no 2830 0.164995953424482 4021 25236002 SGTC_1349 flufenamic acid 69 µM -0.9742562352128 0.177339833121164 no 2831 0.16496466445864 3978 3371 A non-steroidal anti-inflammatory. SGTC_566 0958-0068 16.5 µM -0.974616480536663 0.177250722617334 no 2832 0.164875267772538 3958 6815365 SGTC_2162 5663267 200 µM -0.97521817018198 0.177101951368391 no 2833 0.164726025445109 4044 6456493 SGTC_3058 9093861 49.47 µM -0.977846884102038 0.176452912138181 no 2834 0.164075029400092 4071 17217477 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.978554646445143 0.176278420403932 no 2835 0.163900038939582 4137 1609 A potent and irreversible inhibitor of serine proteases. SGTC_743 1275-0778 158 µM -0.978587333840234 0.17627036429206 no 2836 0.163891960082536 4056 2849257 YMR203W TOM40 SGTC_2801 7907800 81.82 µM -0.980864967631318 0.175709594089114 no 2837 0.163329667589346 4086 6620925 SGTC_377 3970-0964 33.1 µM -0.981314218134652 0.175599118906877 no 2838 0.163218906701091 4021 16481235 SGTC_1257 0669-0121 16 µM -0.981386967097938 0.175581233352654 no 2839 0.163200975332228 4083 4307855 SGTC_26 0302-0163 425.158 µM -0.981729042994712 0.175497148429057 no 2840 0.163116676666197 4114 3100915 SGTC_1304 1165-0502 251 µM -0.982560325912555 0.175292918998712 no 2841 0.162911939392234 4075 767425 SGTC_1650 st011916 45.8 µM -0.98264112590572 0.175273076110798 no 2842 0.162892048016563 3974 242528 SGTC_1028 k015-0029 4.8 µM -0.982870902636952 0.175216655253412 no 2843 0.162835490117331 4019 4588309 SGTC_1531 st059297 52.4 µM -0.984117777149528 0.174910690531614 no 2844 0.162528803567544 4079 7566702 SGTC_108 0509-0257 621.132 µM -0.984384501556502 0.174845284320845 no 2845 0.162463247730348 4036 536624 SGTC_425 3825-7017 13.1 µM -0.984761078162122 0.174752966565921 no 2846 0.162370721592894 4148 3397440 SGTC_3215 9129942 49.47 µM -0.984979699736001 0.174699385685933 no 2847 0.162317021276831 4063 17682944 SGTC_2518 prenyletin 46.28 µM -0.985524943119241 0.174565800131851 no 2848 0.162183142777433 4024 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2327 6189656 200 µM -0.98817171771242 0.173918257936194 no 2849 0.161534278422517 4157 5349088 SGTC_2782 7736369 71.43 µM -0.988775057026008 0.173770863016358 no 2850 0.161386605271093 4110 2950836 YOL077C BRX1 SGTC_46 0329-0187a 2.197 µM -0.989318221254133 0.173638236769129 no 2851 0.16125373588856 4133 46494817 SGTC_585 0kpi-0023 191 µM -0.99028871202793 0.17340142914095 no 2852 0.161016511160712 4024 64601 SGTC_33 0986-0033 35.816 µM -0.991318806077972 0.173150302853517 no 2853 0.16076496643507 4027 2848082 SGTC_1695 st026914 34.495 µM -0.991574382573855 0.173088031826762 no 2854 0.160702595458152 4046 3289191 SGTC_2677 mitomycin C 100 µM -0.991919343332883 0.173004005013512 no 2855 0.160618436176349 4105 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3000 9075062 71.4286 µM -0.992171265211339 0.172942657375843 no 2856 0.160556993567037 4033 17057871 SGTC_1638 st008370 60.6 µM -0.992251897311346 0.172923024896456 no 2857 0.160537331005675 4032 24207134 SGTC_2480 5767542 37.17 µM -0.993416359325776 0.172639657504913 no 2858 0.160253546226245 4033 2867358 SGTC_1534 6-azauridine 81.6 µM -0.99410618352346 0.172471931135464 no 2859 0.160085587627428 4100 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_615 k087-0205 167 µM -0.994550237402593 0.172364017259014 no 2860 0.15997753017246 4080 9642773 SGTC_2331 7980721 200 µM -0.994614954322826 0.172348293364194 no 2861 0.159961785738831 4060 2981221 SGTC_2171 5739187 198.077 µM -0.996705419261436 0.171840877444621 no 2862 0.159453759224226 4020 2262761 SGTC_663 1486-0733 13.9 µM -0.99831134489894 0.171451721768182 no 2863 0.159064204026101 4112 722445 YPR165W RHO1 SGTC_2193 5925765 200 µM -1.00143759409475 0.170695770807367 no 2864 0.158307648284339 4082 877370 SGTC_3181 9108277 49.47 µM -1.00399304466534 0.170079430557958 no 2865 0.157690983055325 4031 17097298 SGTC_2374 9071832 200 µM -1.00629097285315 0.169526420745177 no 2866 0.157137810798471 3995 17381698 SGTC_1574 spiramycin 23.7 µM -1.00786528309536 0.169148220520965 no 2867 0.156759570083806 4065 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2382 9035899 200 µM -1.00797641261045 0.169121544105125 no 2868 0.156732892982385 4081 6462679 SGTC_867 0518-0118 155 µM -1.01183913123501 0.168195985503178 no 2869 0.155807488290373 4078 6848158 SGTC_383 2324-0395 7.37 µM -1.01242605018006 0.168055637670885 no 2870 0.155667194040263 4107 3146421 SGTC_2929 9013348 24.6 µM -1.01322179183819 0.167865475200621 no 2871 0.155477116916741 4103 2995952 SGTC_2208 7283366 200 µM -1.01391588469604 0.167699717424739 no 2872 0.155311445514016 4083 898663 SGTC_1910 st062352 60.4 µM -1.01533157973977 0.167361959179097 no 2873 0.154973897860238 4025 2245730 SGTC_756 0508-1999 28.3 µM -1.01574300432492 0.167263883271732 no 2874 0.154875891810731 4106 6753853 SGTC_720 r052-1644 49.9 µM -1.01846000285928 0.166617132112964 no 2875 0.154229699720364 4136 1422863 YOR257W CDC31 SGTC_2722 naftopidil 47.16 µM -1.01856715193603 0.166591659595511 no 2876 0.154204252726451 4013 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1351 1496-0003 46.5 µM -1.01858638563748 0.166587087439609 no 2877 0.154199685180024 4121 3891978 SGTC_528 3492-0019 172 µM -1.02057306656253 0.166115258135641 no 2878 0.153728377696268 4107 2869262 SGTC_2403 6032726 181.2 µM -1.02162701982924 0.165865299017648 no 2879 0.153478732122064 4178 2881040 SGTC_2777 climbazole 1.536 µM -1.02772766967628 0.16442322764762 no 2880 0.152038974168499 3977 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_295 k015-0027 31 µM -1.03111343862351 0.163626417298482 no 2881 0.151243813272287 4154 3887424 SGTC_268 camptothecin 39.6153 µM -1.03167411921065 0.163494708518005 no 2882 0.151112402736479 4100 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3246 9135460 32.98 µM -1.03203146602256 0.163410800557376 no 2883 0.151028688575837 4093 41446951 SGTC_2002 4023503 131 µM -1.03285165016812 0.163218320392541 no 2884 0.150836664153042 4129 4736863 YCR052W RSC6 SGTC_2968 9090663 33.37 µM -1.03365245146003 0.163030531180029 no 2885 0.150649334594737 4082 25236811 SGTC_121 0557-0495 61.343 µM -1.03391911531303 0.162968029253721 no 2886 0.150586988949135 4228 3104427 SGTC_2807 7945238 51.95 µM -1.0341641687405 0.162910606217751 no 2887 0.15052971094567 4160 17148797 SGTC_546 peri-Naphthalide 147 µM -1.0361539905417 0.162444821165355 no 2888 0.150065153749732 4055 223824 A penicillin ester. SGTC_1476 4112-3294 3.34 µM -1.03759171168941 0.16210881381236 no 2889 0.149730089125528 4147 704369 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.03785084603316 0.162048300142952 no 2890 0.149669750324113 4132 75037 A free radical scavenger. SGTC_1420 4'-methoxyflavone 42 µM -1.03950611082733 0.161662105954588 no 2891 0.149284708771815 4124 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_272 doxorubicin 8.13 µM -1.04152669166114 0.161191492714271 no 2892 0.148815585965752 4127 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1231 0242-0792 125 µM -1.04398359623578 0.160620460741516 no 2893 0.148246489544446 4125 3707635 SGTC_2988 9073640 71.4286 µM -1.04864441586966 0.159540831615824 no 2894 0.147170902744877 4209 9102229 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.04882244744797 0.159499686901358 no 2895 0.147129922033475 4128 2724 A muscle relaxant with antifungal properties. SGTC_711 k292-0785 179 µM -1.04975927710419 0.159283291512564 no 2896 0.146914401264129 4075 4146315 SGTC_1709 st033179 39.1045 µM -1.05232787962454 0.158690964646286 no 2897 0.146324572386237 4122 573381 SGTC_2711 st079103 59.1 µM -1.0535297838042 0.158414298819521 no 2898 0.146049125641599 4097 54693780 SGTC_616 4092-0450 108 µM -1.05783612744942 0.157425622718258 no 2899 0.145065079503055 4158 787165 SGTC_81 0411-0046 9.971 µM -1.06035404273413 0.156849427614411 no 2900 0.144491780804702 4090 12925265 SGTC_1104 tacrolimus 29.8 µM -1.0625799619277 0.156341209435565 no 2901 0.143986239055771 4197 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_671 0560-0003 407 µM -1.06315615816611 0.156209830182226 no 2902 0.143855570304261 4054 3238678 SGTC_2102 5377816 72.7585 µM -1.06735582893205 0.155254455443533 no 2903 0.142905593267876 4204 1379702 SGTC_2960 9079389 5.97 µM -1.06972904796078 0.154716285647518 no 2904 0.142370643644145 4159 16457355 SGTC_192 3455-0609 60.9 µM -1.06998221353496 0.154658948678054 no 2905 0.142313657414702 4232 3769639 SGTC_1286 0929-0070 131 µM -1.07183134051268 0.154240584052112 no 2906 0.141897896767267 4236 1420408 SGTC_2834 9001755 58.44 µM -1.07393716645481 0.153765053687806 no 2907 0.141425422055826 4088 2989575 SGTC_278 4092-0821 23.9 µM -1.07439175181732 0.153662528283742 no 2908 0.141323568858185 4155 877900 SGTC_2074 5212007 75.395 µM -1.07523463746952 0.153472546942475 no 2909 0.141134845717949 4053 758611 SGTC_2557 derrustone 83.84 µM -1.07635471348446 0.153220329391204 no 2910 0.14088432384958 4161 629853 An antioxidant. SGTC_2275 7947463 200 µM -1.07941125701746 0.152533458294741 no 2911 0.140202217449876 4149 1225414 SGTC_2064 5220758 200 µM -1.08240200454239 0.151863353613775 no 2912 0.139536968985984 4235 788518 SGTC_2582 agaric acid 100 µM -1.08282457022619 0.15176883179737 no 2913 0.13944314874679 3880 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_470 aa-861 153 µM -1.08454095108572 0.151385304254305 no 2914 0.139062510086524 4148 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2581 avocatin a 64 µM -1.08576633195362 0.151111885965927 no 2915 0.138791192713918 4148 6710728 A skin care supplement. SGTC_1058 3448-5425 97.3 µM -1.08645546623862 0.150958264402741 no 2916 0.138638766722175 4107 7279705 SGTC_3254 9136651 49.47 µM -1.08672721957382 0.150897713834202 no 2917 0.138578690393815 4133 16454030 SGTC_2388 9080168 200 µM -1.08965656714625 0.150246039329172 no 2918 0.137932227539518 4172 15943073 SGTC_1713 st033146 12.748 µM -1.09426789292534 0.149223990799901 no 2919 0.136918751257428 4186 674619 SGTC_246 cycloheximide 667 µM -1.09604303692175 0.148831790574721 no 2920 0.136529970503496 4069 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_938 3126-1755 342 µM -1.09819141364095 0.148358050461857 no 2921 0.136060457392085 4196 1777771 SGTC_1670 st016595 4.04 µM -1.09841564859211 0.148308662445161 no 2922 0.136011516145213 4212 597879 SGTC_2743 auranofin 4.32 µM -1.10297128223079 0.147307660126845 no 2923 0.135019818263959 4180 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3275 9138069 49.47 µM -1.1034007859021 0.14721352008039 no 2924 0.134926577776249 4278 17617007 SGTC_2515 chrysin 20.77 µM -1.10805389998651 0.146196220366281 no 2925 0.133919269318689 4229 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2874 9043904 71.43 µM -1.11340547047814 0.145032069669 no 2926 0.132767163290342 4147 4463428 SGTC_1655 st012546 55.1 µM -1.11354432668816 0.145001946950753 no 2927 0.132737360940935 4190 720985 YLR208W SEC13 SGTC_2126 5251174 33.877 µM -1.11396760673964 0.144910148844397 no 2928 0.132646541868526 4221 790722 SGTC_2181 6316240 54.2555 µM -1.11549997321446 0.144578146880719 no 2929 0.132318114959405 4222 12779990 SGTC_1260 0700-1617 7.75 µM -1.11641624258034 0.144379873296222 no 2930 0.132122002039541 4196 2853078 SGTC_3225 9130819 49.47 µM -1.11690552693444 0.144274071047432 no 2931 0.132017360612506 4152 4547121 SGTC_1395 3486-0190 4.35 µM -1.11698362468345 0.144257188123964 no 2932 0.132000663428069 4205 6748079 SGTC_838 0109-0203 71.4 µM -1.11756598457847 0.144131337402904 no 2933 0.131876201657044 4226 759422 SGTC_3352 9151559 45.5865 µM -1.11823143688779 0.143987620671316 no 2934 0.131734080532819 4212 17159339 SGTC_2768 sulfasalazine 50.2 µM -1.11831013187964 0.143970631425495 no 2935 0.131717280577772 4178 5384001 An antioxidant and salicylic acid derivative. SGTC_3218 9131285 49.47 µM -1.12085927655322 0.143421034764337 no 2936 0.131173883814669 4182 17156417 SGTC_43 0570-0105 72.5 µM -1.12139690371408 0.143305303242918 no 2937 0.131059476766946 4202 1114046 YDL195W SEC31 SGTC_1844 rapamycin 4 nM -1.12170103963648 0.14323986180712 no 2938 0.130994787187143 4112 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1203 3992-3522 103 µM -1.1239296866032 0.142760936002254 no 2939 0.130521428090557 4341 5322312 SGTC_2177 5811945 192 µM -1.12416065824598 0.142711363256033 no 2940 0.130472438019945 4269 5343475 SGTC_3069 9117009 49.47 µM -1.12545014633278 0.14243481818838 no 2941 0.130199165790628 4209 41904981 SGTC_530 4358-1714 28 µM -1.12989544625229 0.141484254244511 no 2942 0.129260141505306 4222 1564641 SGTC_1214 0358-0031 63.7 µM -1.13013744633832 0.141432629649946 no 2943 0.129209156531163 4315 4301366 SGTC_2277 7947813 106.88 µM -1.1312138835923 0.14120315369095 no 2944 0.12898253989131 4275 1246798 SGTC_16 erodoxin 22.806 µM -1.1315523579988 0.141131049577932 no 2945 0.128911339660079 4234 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2246 7293507 91.5585 µM -1.1324697896857 0.14093573762368 no 2946 0.128718489201514 4271 887656 SGTC_507 nimesulide 162 µM -1.13269430481556 0.140887968554736 no 2947 0.128671325077506 4293 4495 A COX2 inhibitor. SGTC_11 0438-0307 1.3 µM -1.13543216267898 0.140306330559732 no 2948 0.128097145075774 4216 4011476 SGTC_2511 berberine 10.47 µM -1.13672671862776 0.140031880183698 no 2949 0.127826273110063 4204 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_59 0330-0160 1.33 µM -1.13693919800801 0.139986868687019 no 2950 0.12778185213233 4183 4293482 SGTC_1376 2910-0861 41.3 µM -1.13708682853381 0.139955600519677 no 2951 0.127750994785277 4153 1112859 SGTC_1935 st074532 41.6 µM -1.13754239821466 0.139859140716966 no 2952 0.127655805452387 4212 2829742 SGTC_1843 st055809 45.5 µM -1.14080516863767 0.139169620600884 no 2953 0.126975504633608 4295 16413835 SGTC_2976 9009005 19.48 µM -1.14316055926673 0.138673296979639 no 2954 0.126485967180895 4274 2993148 SGTC_3333 9141820 12.094 µM -1.14474296801215 0.138340532630112 no 2955 0.126157823301873 4227 1939433 SGTC_512 prima-1 270 µM -1.14484991732169 0.138318061938677 no 2956 0.126135666666899 4247 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2837 9008476 45.46 µM -1.15031666788505 0.137172777919355 no 2957 0.125006734108448 4249 2992805 SGTC_308 4092-1169 104 µM -1.15100819917684 0.13702836503274 no 2958 0.124864431212283 4170 2268590 YDL196W YDL196W SGTC_1341 1486-1360 280 µM -1.15286848378683 0.1366403964537 no 2959 0.124482184855502 4233 3976547 SGTC_1287 0971-0001 34.6 µM -1.15311643888773 0.136588741372971 no 2960 0.124431297557481 4234 4665869 SGTC_3288 9119690 36.221 µM -1.15499764440715 0.136197275486243 no 2961 0.124045695548746 4230 17595618 YKL019W RAM2 SGTC_1297 1068-0111 14.1 µM -1.15602868532754 0.135983049020738 no 2962 0.123834711967219 4222 767057 SGTC_1862 st057513 3.81 µM -1.15627878011964 0.135931119889085 no 2963 0.123783572540734 4232 5393163 SGTC_3339 9145883 14.936 µM -1.15641689856911 0.135902447099073 no 2964 0.123755336394154 4147 2030670 SGTC_1895 st058434 18.3 µM -1.15735670185106 0.135707457980235 no 2965 0.123563328108827 4260 5393175 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.15848819113419 0.135472952463826 no 2966 0.123332433981414 4218 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2455 5377712 9.75 µM -1.15854266935777 0.135461668653098 no 2967 0.123321324671138 4233 2243908 SGTC_95 0471-0001 561.058 µM -1.15873308007821 0.135422234861947 no 2968 0.123282501237247 4242 4015405 SGTC_1553 gossypol 38.6 µM -1.16233674804782 0.134677403536366 no 2969 0.122549352573152 4130 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1865 st057639 52.2 µM -1.16387671540159 0.134359971298557 no 2970 0.122236988514164 4235 688818 SGTC_2643 anethole 100 µM -1.16470310282347 0.134189840707842 no 2971 0.122069596294745 4232 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_5 0352-0601 109.883 µM -1.16731208755288 0.133653693334017 no 2972 0.121542179485756 4169 762456 SGTC_109 0132-0036 33.701 µM -1.16793293931538 0.133526325306181 no 2973 0.121416908077269 4061 67274 A color developer. SGTC_2826 7992541 19.48 µM -1.1704877854527 0.133003076110467 no 2974 0.120902363387819 4268 2985066 SGTC_231 b-estradiol 524 µM -1.17231532663507 0.132629650802645 no 2975 0.120535240204163 4234 450 A steroid. SGTC_1620 st003704 16.5 µM -1.17538218448786 0.132004617577439 no 2976 0.119920923880771 4251 2834414 SGTC_1539 benzyladenosine 56 µM -1.17613249208067 0.131852012823369 no 2977 0.119770967859032 4257 92208 A nucleotide analog. SGTC_3040 9091894 49.47 µM -1.17632462267506 0.131812955040614 no 2978 0.119732590027936 4106 25236966 SGTC_146 3448-8650 53.125 µM -1.17642162533823 0.131793238626893 no 2979 0.119713217169496 4238 2891488 YIL048W NEO1 SGTC_1457 k015-0032 57.3 µM -1.17784809099024 0.13150353528074 no 2980 0.119428586240748 4249 4302660 SGTC_946 3434-1334 87.4 µM -1.17971015349089 0.131126027696536 no 2981 0.11905775709341 4243 4047976 SGTC_3250 9135583 49.47 µM -1.18051357106943 0.13096337722396 no 2982 0.118898008054745 4305 7699353 SGTC_544 k015-0020 52.4 µM -1.18396506557974 0.130266214424081 no 2983 0.118213445951222 4275 3008304 SGTC_2651 TUB2.036 5 µM -1.18455596769479 0.130147116790494 no 2984 0.118096527655378 4208 15992207 YFL037W TUB2 SGTC_763 3453-1109 128 µM -1.18475424399225 0.130107170651531 no 2985 0.118057314232551 4293 1560353 SGTC_3232 9132874 49.47 µM -1.18513025094342 0.130031440948443 no 2986 0.11798297602637 4221 3784940 SGTC_648 0375-0473 33.3 µM -1.18578284139997 0.129900078365904 no 2987 0.117854034679843 4236 1713139 SGTC_1799 st045822 46.1415 µM -1.18793051533009 0.129468413212502 no 2988 0.11743039308596 4254 3674992 SGTC_2638 epoxomicin 18 µM -1.18960903890464 0.129131736165747 no 2989 0.11710004576619 4249 9915668 A protesome inhibitor. SGTC_1016 4226-1401 38 µM -1.19053844624876 0.128945577630773 no 2990 0.116917414196332 4257 2901613 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.19099444993306 0.128854309048897 no 2991 0.116827881848116 4291 77254 SGTC_3139 9095020 49.47 µM -1.19106317177963 0.128840558341383 no 2992 0.116814393127842 4096 25236292 SGTC_2843 9000894 45.46 µM -1.19398845888503 0.128256174788196 no 2993 0.116241241319454 4216 2242070 SGTC_890 0929-0006 47.2 µM -1.19565164189872 0.127924743261923 no 2994 0.115916264919837 4264 1378169 SGTC_1162 k048-0130 20.1 µM -1.19989867188761 0.12708111604469 no 2995 0.115089347924398 4242 6797406 SGTC_2684 capsaicin 100 µM -1.20195338993046 0.126674360901409 no 2996 0.114690793608099 4310 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3326 9140064 16.379 µM -1.20263997737768 0.126538645314684 no 2997 0.114557835192307 4215 1868434 SGTC_2876 9059903 25.97 µM -1.20283513502203 0.126500087608337 no 2998 0.114520062730349 4271 6916095 SGTC_3096 9117468 49.47 µM -1.20364533477626 0.126340102262632 no 2999 0.11436334461076 4200 41316311 SGTC_2054 5233173 129 µM -1.20415258418942 0.126240010524434 no 3000 0.114265304377185 4318 6889 SGTC_1511 0906-3109 28.5 µM -1.20890326983071 0.125305275485383 no 3001 0.113350004900956 4298 2882180 SGTC_2358 9037157 4 µM -1.20980468886047 0.125128460958858 no 3002 0.113176923297399 4302 2388925 SGTC_2298 7976326 193.81 µM -1.2103606495547 0.1250194954503 no 3003 0.113070267261625 4206 2235818 SGTC_1787 fluconazole 80 µM -1.21144000502196 0.124808136481447 no 3004 0.112863407508913 4036 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1772 st048439 82.2 µM -1.21177246838731 0.124743083962279 no 3005 0.112799744969764 4352 2927068 YDL195W SEC31 SGTC_3292 9120825 59.784 µM -1.21181947997758 0.124733887200064 no 3006 0.112790744912876 4293 24824900 SGTC_2027 5150920 200 µM -1.2120273611915 0.124693225587968 no 3007 0.112750953580519 4238 786715 SGTC_2248 tofa 1.1 µM -1.21274129222654 0.124553651062661 no 3008 0.112614373656525 4285 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1271 0832-2808 169 µM -1.21532178011673 0.124050073025136 no 3009 0.112121694049904 4328 3663794 SGTC_1681 tripelennamine 100 µM -1.21589586436745 0.123938235409376 no 3010 0.112012296856763 4234 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_194 1486-1323 56.904 µM -1.21842590911443 0.123446197087168 no 3011 0.111531082147638 4390 5178754 SGTC_106 0092-0003 11.579 µM -1.21943022209425 0.123251260093867 no 3012 0.111340472490455 4225 1072148 SGTC_712 r015-0009 80.6 µM -1.22262472140033 0.122632642912691 no 3013 0.110735735718927 4336 6813872 YLR060W FRS1 SGTC_1404 3909-7820 48.3 µM -1.22283381757009 0.122592227370883 no 3014 0.110696234863701 4282 23741373 SGTC_3216 9129716 49.47 µM -1.22538418954373 0.122100025976447 no 3015 0.110215250541635 4241 8056934 SGTC_330 1488-0319 80.1 µM -1.22647301414672 0.121890314776119 no 3016 0.110010362217427 4346 6846614 SGTC_2747 doxorubicin 7.63 µM -1.22838033978982 0.121523567650194 no 3017 0.109652112322677 4312 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2740 felodipine 17.08 µM -1.22899273608487 0.121405978659528 no 3018 0.109537264751126 4350 3333 L-type calcium channel blocker SGTC_702 1488-0190 94 µM -1.23047428854378 0.12112182998946 no 3019 0.109259774713055 4335 949357 SGTC_2379 9035213 200 µM -1.23082078024124 0.121055443495649 no 3020 0.109194950859268 4306 646551 SGTC_2888 9058547 12.99 µM -1.23139435859676 0.120945604329191 no 3021 0.109087702945643 4212 16476514 SGTC_892 0929-0076 29 µM -1.23371299879928 0.120502303920921 no 3022 0.108654934217193 4287 5751038 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.23646534976771 0.119977569263601 no 3023 0.108142818954838 4407 688664 SGTC_363 0455-0021 3.06 µM -1.23764839295551 0.119752518186628 no 3024 0.107923231184699 4278 4597466 SGTC_1418 3966-3099 2.4 µM -1.23962896990662 0.11937641839601 no 3025 0.107556330156689 4323 740335 SGTC_2877 9040724 71.43 µM -1.23976745299799 0.119350152491667 no 3026 0.1075307098857 4296 6463895 SGTC_2089 5281248 129.67 µM -1.2464380031527 0.118089784468196 no 3027 0.106301818291716 4309 2737878 SGTC_1950 st077106 7.18 µM -1.24660652615698 0.118058065245355 no 3028 0.106270903806424 4248 13831864 SGTC_3242 9133940 49.47 µM -1.25294908919056 0.116868653466822 no 3029 0.105112117609684 4335 17248444 SGTC_872 0588-0139 234 µM -1.25381899324425 0.116706186321204 no 3030 0.104953902014426 4284 2047100 SGTC_3332 9141069 11.198 µM -1.25777825927618 0.115968759364717 no 3031 0.104235980185021 4281 17332883 SGTC_534 k292-0788 63.4 µM -1.25783464983511 0.115958280376418 no 3032 0.104225780828033 4378 4146317 SGTC_692 k241-0027 77.8 µM -1.25806724902058 0.115915063860828 no 3033 0.10418371827321 4370 3600480 SGTC_2225 6654152 15.4 µM -1.26005833581499 0.115545591361269 no 3034 0.103824159409194 4251 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1742 st038235 28.8875 µM -1.26231854851664 0.115127193900967 no 3035 0.103417092465477 4377 564103 YBR002C RER2 SGTC_2746 daunorubicin 9.88 µM -1.26451438642954 0.114721745851811 no 3036 0.103022730180753 4326 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_701 4424-0219 185 µM -1.26452981778212 0.114718900146469 no 3037 0.103019962652165 4364 2911779 SGTC_2625 euphol 100 µM -1.26467710072181 0.114691742135168 no 3038 0.102993550980808 4346 6708538 A triterpene alcohol. SGTC_713 1488-1073 324 µM -1.26526000617069 0.114584303063896 no 3039 0.102889069091577 4358 3312542 SGTC_1520 flindersine 88 µM -1.26907416231609 0.113883058864903 no 3040 0.102207307278168 4386 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3183 9108214 49.47 µM -1.26971127053681 0.11376622329529 no 3041 0.102093748329314 4309 4974831 SGTC_2907 7721985 69.9 µM -1.27058459514888 0.113606208230129 no 3042 0.10193823508157 4342 3267881 SGTC_3131 9127911 49.47 µM -1.27254948208493 0.11324677824352 no 3043 0.101588977333447 4373 45595681 SGTC_2111 5486399 200 µM -1.28095148880637 0.111718980587973 no 3044 0.100105352964834 4299 689674 SGTC_1173 0443-0020 122 µM -1.28391228130909 0.11118412752513 no 3045 0.0995863247833701 4350 5331295 SGTC_818 4072-2707 53.5 µM -1.28669941717493 0.110682322299729 no 3046 0.0990995381556713 4264 882871 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.28790361432176 0.110466017494504 no 3047 0.0988897585954921 4395 23665772 A membrane-active detergent. SGTC_1057 3448-5381 134 µM -1.28815877022625 0.110420223862846 no 3048 0.0988453503997597 4333 5497911 SGTC_1503 4585-0012 61.3 µM -1.2906076329558 0.10998141084548 no 3049 0.0984198839415399 4389 2922052 SGTC_2398 5228213 48.84 µM -1.29138516518628 0.109842346499193 no 3050 0.0982850760513172 4331 80771 YMR134W ERG29 SGTC_1402 3909-7673 35.9 µM -1.29306100553398 0.109543045855468 no 3051 0.0979949802225037 4370 5328014 SGTC_2073 5212005 126 µM -1.29489247091187 0.109216621230866 no 3052 0.0976786630755581 4256 691789 SGTC_790 1575-0012 79.1 µM -1.29541258022086 0.109124048973891 no 3053 0.0975889702806709 4400 378741 YLR208W SEC13 SGTC_365 0121-0052 13.6 µM -1.29580083088106 0.109054982496289 no 3054 0.0975220558756406 4370 3101739 SGTC_1389 3405-0187 19 µM -1.30161489819978 0.108024465435417 no 3055 0.0965240321642084 4342 799890 SGTC_2738 aclarubicin 5.55 µM -1.30308929567369 0.107764253265526 no 3056 0.0962721388275443 4378 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2662 daunorubicin 22.37 µM -1.30746691752051 0.106994320602145 no 3057 0.0955270917114088 4260 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2715 st079500 56.4 µM -1.31246605502181 0.106119938472166 no 3058 0.0946814660411008 4347 28246688 SGTC_570 0987-0065 62.6 µM -1.31337331312282 0.105961808073486 no 3059 0.0945285927495537 4216 3104428 SGTC_214 4373-3496 70 µM -1.31402158093211 0.105848922694193 no 3060 0.0944194709281986 4474 3779166 SGTC_2488 5268135 45.7 µM -1.31583373629919 0.105533826242241 no 3061 0.0941149266713728 4412 1270356 YLR208W SEC13 SGTC_1578 josamycin 24.2 µM -1.3160821220921 0.10549068999123 no 3062 0.0940732403943293 4377 5282165 A P450 substrate. SGTC_802 4112-3352 742 µM -1.31997079551889 0.104817020227912 no 3063 0.0934223843971265 4421 704594 SGTC_1700 st030840 7.9285 µM -1.32142697703746 0.104565556216393 no 3064 0.0931795179604846 4411 5499307 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.32217268342996 0.1044369515485 no 3065 0.0930553275401583 4393 61125 An anti-inflammatory. SGTC_2905 7799065 20.05 µM -1.32246685829414 0.104386249631149 no 3066 0.0930063691357519 4266 1296806 SGTC_2963 9082507 9 µM -1.32314373628777 0.104269655428465 no 3067 0.0928937912168556 4401 16459611 SGTC_130 0136-0219 337.655 µM -1.32365344814544 0.104181918401126 no 3068 0.0928090827856175 4209 234244 SGTC_1870 st057514 26.5 µM -1.323797510634 0.104157130536174 no 3069 0.0927851515616397 4379 5393161 SGTC_1210 3013-0140 750 nM -1.32701710614057 0.103604271420137 no 3070 0.0922515120502834 4409 905973 SGTC_632 0781-2353 4.65 µM -1.33032578025857 0.103038337814136 no 3071 0.0917054783295284 4437 6811515 YHR007C ERG11 SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.33532314265454 0.102187824066258 no 3072 0.0908853036973903 4430 804 An inhibitor of viral and cellular DNA polymerases. SGTC_31 0508-1974 57.237 µM -1.33568801898026 0.102125925487186 no 3073 0.0908256335199354 4333 6810525 SGTC_1339 1486-1321 22.7 µM -1.33745693007203 0.10182622941438 no 3074 0.0905367660465432 4416 3469382 SGTC_2354 9060492 162 µM -1.33805938692608 0.101724305025205 no 3075 0.090438539247119 4416 6471895 SGTC_2567 aureobasidin a 60 nM -1.34362768954342 0.100785766856702 no 3076 0.0895344054541936 4493 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_734 2023-0417 80 µM -1.34665276658028 0.100278544502069 no 3077 0.0890460456217442 4409 3935732 SGTC_1794 st048918 76.9 µM -1.34854037139085 0.0999629904709869 no 3078 0.0887423222456991 4352 672303 SGTC_828 2074-0507 139 µM -1.34891009194867 0.0999012686911033 no 3079 0.0886829231461382 4460 X828 SGTC_2249 haloperidol 116.36 µM -1.35500852984824 0.0988871981035235 no 3080 0.0877074196970922 4363 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2809 7964133 12.99 µM -1.35518303829821 0.0988582914486129 no 3081 0.0876796236911226 4388 1253665 SGTC_662 k832-1615 104 µM -1.36898185556885 0.0965921015004993 no 3082 0.0855024733484812 4430 5878478 SGTC_2886 9058944 51.95 µM -1.37000562221829 0.0964255008642264 no 3083 0.0853425733112268 4351 4949929 SGTC_1222 0366-0074 1.18 µM -1.37128947963104 0.0962168734216263 no 3084 0.0851423669578478 4433 286520 SGTC_2269 7935389 174.42 µM -1.37356702466979 0.0958475880030478 no 3085 0.0847880700059848 4400 97605 SGTC_3050 9093513 49.47 µM -1.37579688795028 0.0954870448385313 no 3086 0.0844422626089815 4375 25236664 SGTC_138 0850-0259 40.9225 µM -1.37598149879513 0.0954572401967373 no 3087 0.0844136806418235 4345 6813004 SGTC_1623 st003709 20.3 µM -1.37627273953341 0.0954102345317912 no 3088 0.0843686046960808 4390 16192618 SGTC_468 gf-109203x 121 µM -1.37698721119837 0.0952949924273646 no 3089 0.0842581009103124 4470 2396 A protein kinase C inhibitor. SGTC_800 3448-7362 155 µM -1.3809688481163 0.0946546430168788 no 3090 0.0836442695954916 4498 15991913 SGTC_1472 k841-0093 193 µM -1.38175359376097 0.0945288107949026 no 3091 0.0835236861840637 4527 X1472 SGTC_134 0269-0018 6.916 µM -1.38688821914989 0.0937085270698757 no 3092 0.0827379253572079 4382 4378915 SGTC_3119 9125183 49.47 µM -1.38758004900577 0.0935984065466961 no 3093 0.082632480064463 4278 22695334 SGTC_320 4092-0846 5.34 µM -1.38794953897659 0.0935396329391359 no 3094 0.082576205676677 4386 1359356 SGTC_2946 9065502 71.43 µM -1.38914915211178 0.0933490021468229 no 3095 0.0823937000002228 4273 16489101 SGTC_1796 st049173 110.4 µM -1.39133706430932 0.0930020598724965 no 3096 0.0820616197236742 4416 94134 SGTC_909 3448-9333 149 µM -1.39276782646929 0.0927756966539138 no 3097 0.0818450052614304 4359 3344074 SGTC_2896 9052656 71.43 µM -1.39585839442726 0.0922881238855913 no 3098 0.0813785708208627 4150 6469436 SGTC_1484 3473-2379 286 µM -1.39806011780379 0.0919419351512853 no 3099 0.0810475074654941 4552 671917 SGTC_3269 9137823 49.47 µM -1.40101915238333 0.0914781863854074 no 3100 0.0806041729673137 4368 17682936 SGTC_441 propafenone 146 µM -1.40218592626241 0.0912958034441882 no 3101 0.0804298665911635 4423 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1791 st048313 56.1 µM -1.40588275193766 0.0907197186720214 no 3102 0.0798794719160435 4459 1204976 SGTC_2621 lithochol-11-enic acid 100 µM -1.40757024020849 0.0904576521216746 no 3103 0.0796291823935759 4397 6708711 SGTC_244 nsc-207895 1.295 µM -1.41011715190037 0.0900631823185872 no 3104 0.0792525467505585 4221 42640 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.41178187322545 0.0898060391935624 no 3105 0.0790070986961639 4441 229346 A bile salt which induces apoptosis. SGTC_2445 5742597 35.57 µM -1.41212013206075 0.0897538564232171 no 3106 0.0789572959542048 4457 1774255 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.41468677046477 0.0893586385038745 no 3107 0.0785801774811101 4441 688669 SGTC_420 mitomycin C 81.9 mM -1.41816523929171 0.0888250826238428 no 3108 0.0780712639388207 4423 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_467 ro 31-8220 72.8 µM -1.41874334673911 0.0887366381557438 no 3109 0.0779869274229669 4395 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1361 1608-0041 5.61 µM -1.42165671821712 0.0882919202574781 no 3110 0.0775629653361452 4434 X1361 SGTC_2129 girgensonine 121.053 µM -1.42224889569937 0.088201729523951 no 3111 0.077477004398454 4448 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2691 st077356 60.2 µM -1.43152703065856 0.0867975907926518 no 3112 0.0761396128578077 4451 2839272 SGTC_565 1418-0001 44.5 µM -1.43492924897531 0.0862869114895232 no 3113 0.0756536299428961 4495 2862145 SGTC_2698 st077697 67.5 µM -1.43500682834784 0.0862752929416831 no 3114 0.0756425758981103 4430 3154499 SGTC_2666 tannic acid 100 µM -1.43863376374501 0.0857334160261391 no 3115 0.0751271574475272 4439 16134267 A thiamine antagonist. SGTC_1459 k035-0031 35.7 µM -1.43928564447661 0.0856362934541599 no 3116 0.0750348042260916 4187 3877128 YMR208W ERG12 SGTC_334 1502-1024 68.5 µM -1.44413601778768 0.0849162301418093 no 3117 0.0743503591404193 4464 3296216 SGTC_907 3448-6986 75.5 µM -1.44630276467615 0.0845960358105048 no 3118 0.074046150334459 4479 590582 SGTC_2972 9093619 59.92 µM -1.44760464215003 0.0844040849042269 no 3119 0.073863826075152 4415 25236256 SGTC_1377 2944-0135 198 µM -1.4504140807088 0.0839909706140536 no 3120 0.0734715414327382 4473 1894137 SGTC_1748 st037455 53.6035 µM -1.45267153738648 0.0836601241516192 no 3121 0.0731574866200706 4476 580690 SGTC_1902 st060212 70.5 µM -1.45278769451209 0.083643127016123 no 3122 0.0731413548019163 4468 688944 SGTC_1220 1838-0075 193 µM -1.45383835274341 0.0834895032861473 no 3123 0.0729955637742073 4403 5529645 SGTC_412 gemfibrozil 100 µM -1.45392578825558 0.0834767283219499 no 3124 0.0729834411139767 4419 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_996 3970-0799 1.8 µM -1.45594212264155 0.0831825346188926 no 3125 0.072704309967586 4453 6615648 YGL040C HEM2 SGTC_331 k048-0133 24.5 µM -1.45602049394199 0.083171115597453 no 3126 0.0726934771685847 4441 6813582 SGTC_1758 st042942 75.2445 µM -1.46713866965848 0.0815630690803586 no 3127 0.0711691683051563 4447 669317 SGTC_2160 5660466 132.927 µM -1.46786244885898 0.081459205741885 no 3128 0.0710707950548671 4407 2859134 SGTC_71 0417-1750 47.813 µM -1.47490654004289 0.0804535726536404 no 3129 0.0701188359045787 4440 6811472 SGTC_2642 cholecalciferol 100 µM -1.47514526298068 0.0804196569971978 no 3130 0.0700867468694224 4478 9821465 A vitamin D precursor, similar to steriods. SGTC_2745 rifampicin 24.3 µM -1.47705816661405 0.0801482784443604 no 3131 0.0698300229911033 4577 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2713 st079149 53.4 µM -1.47800816415797 0.0800137623411281 no 3132 0.0697027965139295 4509 3103253 SGTC_2898 9056270 58.44 µM -1.47829479672794 0.0799732097791417 no 3133 0.0696644448957177 4493 19154699 SGTC_588 3970-1144 52.9 µM -1.48265639602921 0.0793580499167033 no 3134 0.069082862593056 4383 1888707 SGTC_2377 9073351 62.6 µM -1.48311940357065 0.079292958211642 no 3135 0.0690213447934166 4481 7337946 YHR072W ERG7 SGTC_2024 5144227 134 µM -1.49593443440623 0.0775073623767106 no 3136 0.067335370941258 4467 3475211 SGTC_1508 1080-0625 72.9 µM -1.50287872572348 0.076552615288939 no 3137 0.0664351599806866 4422 767111 SGTC_1822 st052468 42 µM -1.50295075567503 0.0765427592244967 no 3138 0.0664258715730271 4520 2873678 SGTC_793 0488-0545 106 µM -1.50595496491679 0.0761325437836582 no 3139 0.066039367501508 4515 292548 SGTC_638 3970-0837 4.09 µM -1.50626453926321 0.0760903676578937 no 3140 0.0659996386978692 4485 4118451 YLR208W SEC13 SGTC_2985 9022375 71.43 µM -1.51019979318638 0.0755557812835432 no 3141 0.0654962257295176 4527 4939335 SGTC_462 ag-879 158 µM -1.51487789093288 0.0749240116616106 no 3142 0.0649016651513881 4527 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1889 st059080 5.18 µM -1.51719856842467 0.0746121069973611 no 3143 0.0646082788294164 4469 176925 Isolated from Daphnopsis sellowiana. SGTC_2262 9014885 67.46 µM -1.52045244346627 0.0741764484778856 no 3144 0.0641986512229226 4539 6457424 SGTC_2195 6536160 144.242 µM -1.52866565959202 0.0730854313903504 no 3145 0.0631736747924875 4512 3834386 SGTC_2678 equilin 100 µM -1.52905823067563 0.0730335926768702 no 3146 0.0631250044589288 4505 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1692 fluoroquinolonic acid 71 µM -1.53429744837519 0.0723444490586532 no 3147 0.0624782465973962 4523 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2620 irigenin 100 µM -1.54048244927903 0.0715373270972382 no 3148 0.061721398822085 4503 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1798 st045719 60.953 µM -1.54070762787567 0.0715080729347164 no 3149 0.0616939797513525 4481 3980186 SGTC_1954 st077032 68.9 µM -1.54442369763353 0.0710266231103641 no 3150 0.0612428614019338 4449 698907 SGTC_42 0133-0086 60.653 µM -1.54531418039346 0.0709116237648873 no 3151 0.0611351435597748 4410 162923 Model of phenazepam hydroxylation. SGTC_2576 guaiol 23.12 µM -1.54825609311963 0.0705327139042993 no 3152 0.0607803255266706 4420 227829 SGTC_2549 cedrol 20.94 µM -1.55184735180981 0.0700722819332201 no 3153 0.0603493763862357 4462 6708665 A sedative which affects the nervous system. SGTC_695 3505-6186 243 µM -1.5571735252606 0.0693936803178744 no 3154 0.0597146461257601 4515 1819379 SGTC_2176 5809774 33.9695 µM -1.55928484484832 0.0691260847328622 no 3155 0.0594644885397101 4443 2870539 SGTC_2010 4012422 159 µM -1.55987856884338 0.0690509776281711 no 3156 0.0593942899308336 4475 952393 SGTC_3045 9092950 49.47 µM -1.55989313938258 0.0690491352209101 no 3157 0.0593925680087534 4503 44120432 SGTC_1147 3809-1045 12.3 µM -1.56907939923188 0.0678950800730417 no 3158 0.0583147196576872 4548 325925 SGTC_1792 st045773 43.6 µM -1.57450042862199 0.0672210671062527 no 3159 0.0576859012585292 4513 2919270 SGTC_2964 9083345 53.42 µM -1.57829977569574 0.066751774500885 no 3160 0.0572483787173369 4500 17741579 SGTC_273 hydroxyurea 18.1 mM -1.58187984748803 0.0663118903633069 no 3161 0.0568385011525472 4590 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1416 3966-0321 25.3 µM -1.5839398090436 0.0660598018356061 no 3162 0.0566037085528326 4586 582530 YLR208W SEC13 SGTC_3262 9137218 49.47 µM -1.5846652577218 0.0659712017849315 no 3163 0.0565212047348223 4538 17650664 SGTC_85 0868-0259 160.055 µM -1.58588988325752 0.0658218455230508 no 3164 0.0563821455733453 4484 83173 SGTC_1140 3229-1848 2.98 µM -1.58677769193376 0.065713731669353 no 3165 0.0562815014927224 4528 2849525 SGTC_857 0438-0306 1.35 µM -1.59039485941371 0.065274669711175 no 3166 0.0558729141706371 4583 4686136 SGTC_1398 3558-0053 112 µM -1.59715297263157 0.0644604532510678 no 3167 0.0551158062777394 4524 4532369 SGTC_2670 beta-carotene 100 µM -1.59832906010438 0.0643195679768618 no 3168 0.0549848816383367 4528 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2362 9071156 126 µM -1.6008791047657 0.0640149163251694 no 3169 0.0547018492235131 4538 653133 SGTC_178 4092-0806 87.505 µM -1.60470373660763 0.0635600956680341 no 3170 0.0542795096170314 4433 2169044 SGTC_2475 5812728 15.03 µM -1.61021187452197 0.0629094979537578 no 3171 0.0536758049785363 4511 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1350 1495-0454 146 µM -1.61677457051895 0.0621411269519129 no 3172 0.0529634752349764 4580 1069057 SGTC_571 k831-0106 44.2 µM -1.61787293558229 0.0620132468457169 no 3173 0.0528449919928393 4453 4783639 SGTC_262 fenpropimorph 62.5 µM -1.62015514642901 0.0617481910117758 no 3174 0.0525994768792357 4587 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2288 7946289 167.31 µM -1.62193455789724 0.0615421445458981 no 3175 0.0524086805675629 4566 1246052 SGTC_668 1682-0499 62.6 µM -1.62351953097068 0.0613590655249093 no 3176 0.0522391958424914 4544 682214 SGTC_3347 9188721 44.724 µM -1.62570372429404 0.0611074685386869 no 3177 0.0520063487056235 4562 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2778 tioconazole 65.09 nM -1.63700579501085 0.0598184428336642 no 3178 0.0508146293617655 4454 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1522 st012842 45.6 µM -1.6391364057461 0.0595778456412402 no 3179 0.0505924272751213 4408 3491067 YOR116C RPO31 SGTC_2523 spermine 47.74 µM -1.63957644889603 0.0595282488079461 no 3180 0.0505466316061525 4560 1103 A DNA binding polyamine. SGTC_960 1222-0186 7.7 µM -1.64046057301101 0.059428697872576 no 3181 0.0504547198800054 4548 3126296 SGTC_2688 kanamycin b 96.69 µM -1.64446344900811 0.0589796126802692 no 3182 0.0500402541669185 4529 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2520 obtusaquinone 4.71 µM -1.6445008323473 0.058975431203284 no 3183 0.0500363962559379 4588 5967872 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.64854827189087 0.0585240829600836 no 3184 0.0496201067970006 4570 688662 SGTC_1112 tnp00069 1.16933 µM -1.65008474282131 0.0583534560727449 no 3185 0.0494628024212813 4535 145826 SGTC_3013 9080133 71.4286 µM -1.65732680270372 0.0575544722815391 no 3186 0.0487267106314825 4609 17050193 SGTC_2221 6807166 181.081 µM -1.66420153293572 0.0568039996157311 no 3187 0.0480360809238147 4568 674925 SGTC_976 1348-1067 47.6 µM -1.66577512903916 0.0566333083956136 no 3188 0.047879105796297 4588 5310671 YGL099W LSG1 SGTC_96 0929-0093 37.281 µM -1.66657313050811 0.0565469020866044 no 3189 0.0477996577075383 4578 6991579 SGTC_851 0394-0702 453 µM -1.66764214032582 0.0564313142586483 no 3190 0.0476933937980056 4582 762646 SGTC_3319 9138450 16.7555 µM -1.66813187070359 0.0563784238713568 no 3191 0.0476447758412505 4513 2029690 SGTC_1471 k673-0312 37 µM -1.66952969773979 0.0562276748679832 no 3192 0.0475062249489232 4563 24099884 SGTC_3003 9075612 71.4286 µM -1.67813619856208 0.0553064954653914 no 3193 0.046660256753746 4589 6501993 SGTC_2839 9003951 25.97 µM -1.69806884082944 0.0532188098169116 no 3194 0.0447473848428502 4640 2990634 SGTC_327 1273-0057 3.96 µM -1.69859810544876 0.0531642396251651 no 3195 0.0446974668394071 4505 3108138 SGTC_2664 lyso-paf C-16 73.48 µM -1.70319666910023 0.0526919667861334 no 3196 0.0442656349110517 4583 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2989 9073649 71.4286 µM -1.70352774113548 0.052658094535495 no 3197 0.0442346755300383 4553 21367202 SGTC_23 0213-0011 39.996 µM -1.70426393596242 0.0525828357717752 no 3198 0.0441658946507025 4590 627608 SGTC_3041 9091929 49.47 µM -1.70699493894976 0.0523043998127719 no 3199 0.0439114965447009 4565 25236887 SGTC_1469 k284-2957 126 µM -1.71036369354209 0.0519625568753824 no 3200 0.0435993201894009 4601 23884841 SGTC_299 1273-0059 1.44 µM -1.71059608751714 0.0519390404036935 no 3201 0.0435778508714701 4354 2848077 SGTC_2630 antimycin a 100 µM -1.71164540610896 0.0518329627620863 no 3202 0.0434810175928621 4527 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3012 9080433 71.4286 µM -1.71211980228697 0.0517850616882174 no 3203 0.0434372963867203 4574 17688859 SGTC_881 0833-0569 170 µM -1.71312230329488 0.0516839521708555 no 3204 0.0433450208304688 4616 5418700 SGTC_2881 9058953 51.95 µM -1.71403901250366 0.0515916328051513 no 3205 0.0432607806079317 4560 17122249 SGTC_1879 gemcitabine 100 µM -1.72007692971237 0.0509868416729343 no 3206 0.0427092293447434 4572 60750 A nucleoside analog which inhibits DNA replication. SGTC_633 0437-0093 97.7 µM -1.72808333390535 0.050193594253836 no 3207 0.0419866425028515 4538 2831118 SGTC_2130 NSC 7 2.4545 µM -1.73165947782859 0.049842475124476 no 3208 0.0416671047687134 4631 21448 SGTC_2026 5148700 152 µM -1.7319892858796 0.0498101922615623 no 3209 0.041637735041633 4594 79838 SGTC_1645 Cervolide 78 µM -1.74257148309832 0.048783191324659 no 3210 0.0407042474443996 4626 23173 A fragrance. SGTC_2460 5552655 174.22 µM -1.74284239932113 0.0487571228081349 no 3211 0.0406805739187227 4580 5401989 SGTC_1744 st037937 38.9 µM -1.74569477281138 0.0484833325588847 no 3212 0.0404320019442513 4622 1016152 SGTC_1332 1480-0653 17.5 µM -1.7460032238893 0.0484537991307744 no 3213 0.040405195820418 4616 5749438 SGTC_3043 9092303 49.47 µM -1.75346940678959 0.0477433093240908 no 3214 0.0397607331983559 4602 25236084 SGTC_1138 3761-0006 1.03 µM -1.76825481039069 0.0463609441177499 no 3215 0.0385091574342771 4642 12061087 SGTC_1152 3909-8331 15.9 µM -1.77075855736086 0.0461300689527639 no 3216 0.038300430106545 4627 16001939 SGTC_762 1165-0429 115 µM -1.7707860266573 0.0461275410885713 no 3217 0.0382981452274743 4628 5967793 SGTC_1633 st005664 67.9 µM -1.77162298059772 0.0460505736597733 no 3218 0.038228581180185 4600 2063822 SGTC_2982 9019404 25.97 µM -1.77725072532962 0.0455357140458494 no 3219 0.0377634984565578 4566 22333232 SGTC_433 pimozide 108 µM -1.78899307217755 0.0444763589935418 no 3220 0.0368079656374813 4547 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1998 st075797 76.8 µM -1.79289832222495 0.0441284727325323 no 3221 0.0364945918405994 4623 24208315 SGTC_1845 st056753 3.01 µM -1.79333500774192 0.0440897087963271 no 3222 0.0364596864563953 4596 5375839 SGTC_764 1951-2361 146 µM -1.79814480203882 0.0436645644158073 no 3223 0.0360770320285679 4617 5438930 SGTC_2077 5212015 200 µM -1.80345159587575 0.0431993344710761 no 3224 0.0356586603767695 4567 780900 SGTC_2390 9097792 176.6 µM -1.80385725752515 0.0431639367267641 no 3225 0.0356268435188353 4640 4497149 SGTC_1846 st056244 14.8 µM -1.80930410660372 0.0426909139278247 no 3226 0.0352018856828757 4640 5393182 SGTC_3266 9136860 49.47 µM -1.81166602523746 0.0424871037206046 no 3227 0.0350189081347578 4372 4871271 YPR165W RHO1 SGTC_2346 9031566 143.75 µM -1.81555508405837 0.0421532316288073 no 3228 0.0347193244640666 4625 4771086 SGTC_3007 9078383 71.4286 µM -1.8160602030156 0.0421100238523363 no 3229 0.0346805688062832 4630 6496995 SGTC_1524 corynanthine 62.1 µM -1.81853263337173 0.0418990494848288 no 3230 0.0344913818310109 4674 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1493 4348-0038 111 µM -1.81930787091769 0.0418330743903993 no 3231 0.0344322366228158 4638 800424 SGTC_2955 9076254 12.21 µM -1.82007337585169 0.0417680101407951 no 3232 0.0343739157413813 4585 16459619 SGTC_2669 eugenol 100 µM -1.84102862585531 0.0400185171887414 no 3233 0.0328086819380834 4673 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_270 tamoxifen 5.46 µM -1.85997713352204 0.0384882735615732 no 3234 0.0314443805988 4640 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1142 3253-1408 9.78 µM -1.86132230638372 0.0383814783069796 no 3235 0.0313493374707828 4641 256655 SGTC_2858 9025781 8.96 µM -1.86766552021845 0.0378811320462417 no 3236 0.0309043537606649 4462 4894980 YPL153C RAD53 SGTC_3271 9137798 49.47 µM -1.87445821681313 0.037351245814978 no 3237 0.0304336479464239 4652 6498326 SGTC_1644 st010134 20.9 µM -1.87688722158762 0.037163239388727 no 3238 0.0302667763044929 4645 3818134 SGTC_1288 0973-0013 65.5 µM -1.87735108992872 0.0371274237899509 no 3239 0.03023499513083 4671 4315430 SGTC_3235 9132602 49.47 µM -1.87777534886898 0.0370946911633904 no 3240 0.0302059519521887 4631 4912240 SGTC_1813 st051246 8.6015 µM -1.88335571072182 0.0366663437021388 no 3241 0.0298260890881409 4626 5291959 SGTC_1488 4013-0813 75.9 µM -1.88419194507153 0.0366025044817142 no 3242 0.0297695083551838 4683 2910057 SGTC_954 1189-0853 2.85 µM -1.88831482275759 0.0362890866357549 no 3243 0.0294918492751471 4602 2828194 SGTC_427 1354-0053 47.3 µM -1.89165671753767 0.0360366535573566 no 3244 0.0292683668485986 4655 6813657 SGTC_2056 5235370 200 µM -1.89322120165408 0.0359189740100941 no 3245 0.0291642295161138 4577 5511916 SGTC_1428 4049-0204 61.7 µM -1.89365627527007 0.0358863040407757 no 3246 0.0291353243132738 4690 X1428 SGTC_950 1165-0508 94.1 µM -1.90175379061204 0.035282686404898 no 3247 0.0286016749910246 4643 6148369 SGTC_3195 9113082 49.47 µM -1.9160085210773 0.0342403340313199 no 3248 0.0276820055428208 4631 17018038 SGTC_349 k015-0014 24 µM -1.92271381102347 0.0337588482813004 no 3249 0.0272580006944547 4656 2196908 SGTC_3217 9129673 49.47 µM -1.92665718634582 0.0334782978054329 no 3250 0.0270111833909602 4628 17248312 SGTC_666 0272-0154 136 µM -1.93117344106212 0.0331593508399076 no 3251 0.0267308036331787 4664 6870312 SGTC_1562 morin hydrate 59.1 µM -1.93181028379949 0.0331145777647916 no 3252 0.0266914631596154 4661 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_168 3970-0862 530.542 µM -1.93680310179109 0.0327652821577914 no 3253 0.0263847083138476 4603 3135186 SGTC_700 3453-2283 142 µM -1.9449021208868 0.0322051419451283 no 3254 0.0258933798695316 4695 565664 SGTC_798 1287-0182 476 µM -1.95268746163265 0.0316741704129569 no 3255 0.0254283201547723 4700 1649755 SGTC_354 2783-3500 4.88 µM -1.96483334701715 0.0308602647005135 no 3256 0.0247167646093433 4667 6740761 SGTC_2041 5107442 45.335 µM -1.9692750859131 0.0305669765834521 no 3257 0.0244607552759937 4686 793005 SGTC_2324 6149169 200 µM -1.97648212415504 0.0300960099167817 no 3258 0.0240500991892558 4659 2888231 SGTC_14 0354-0009 295 µM -1.97785641220926 0.030006889227001 no 3259 0.0239724536861574 4747 1713507 SGTC_414 piperonyl butoxide 100 µM -1.98092931502195 0.0298084072607456 no 3260 0.0237996005178454 4687 5794 A potent inhibitor of cytochrome P450. SGTC_990 3985-0011 41.3 µM -1.9822382203778 0.0297241950996082 no 3261 0.023726292424105 4659 5399565 YGL099W LSG1 SGTC_2645 abamectin 100 µM -1.98535417429953 0.029524515397301 no 3262 0.0235525403194865 4660 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_161 4065-0411 162.148 µM -1.98658358809049 0.0294460377963023 no 3263 0.0234842807118281 4672 1906281 YLR208W SEC13 SGTC_518 1021-0119 62.6 µM -1.98915481341629 0.0292824676555539 no 3264 0.0233420588643079 4651 1097762 SGTC_2473 5854593 8.94 µM -2.00216847514577 0.0284661290106019 no 3265 0.0226333074849144 4667 2872951 SGTC_1479 0549-0158 134 µM -2.00667477752488 0.028187902234023 no 3266 0.0223921516803239 4725 5440202 SGTC_180 1486-1293 102.781 µM -2.01518616049525 0.0276685702246425 no 3267 0.0219425735303873 4625 4140536 SGTC_599 1935-0052 86.5 µM -2.01530636292477 0.0276612934250593 no 3268 0.0219362793216964 4689 9557311 SGTC_3084 9116877 49.47 µM -2.01664924760943 0.0275801064338379 no 3269 0.02186606489698 4653 27241325 SGTC_502 l-744,832 89.3 µM -2.06245886862021 0.0249272744216754 no 3270 0.0195820348185065 4706 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3136 9095672 49.47 µM -2.067259238066 0.0246621051285174 no 3271 0.0193548664833805 4596 17217380 SGTC_1331 1472-0049 76.2 µM -2.09984876306305 0.0229237615666965 no 3272 0.017871073563556 4703 24051409 SGTC_2053 5265679 138 µM -2.10001083833191 0.0229153812528742 no 3273 0.01786394385943 4626 764595 SGTC_1466 k213-0079 57.5 µM -2.10481327964102 0.0226682334414313 no 3274 0.0176537823780358 4721 3657981 SGTC_690 glyoxal 20.3 µM -2.1090353366186 0.0224528134939835 no 3275 0.0174707658026178 4545 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2094 5332512 191.667 µM -2.11891804995079 0.0219553146312236 no 3276 0.0170486966221806 4719 755774 SGTC_2461 5755302 26.15 µM -2.13649425813287 0.021093513142723 no 3277 0.0163195742464795 4702 2788904 SGTC_1859 st055998 20 µM -2.13658873071223 0.0210889594055285 no 3278 0.016315728505425 4674 676301 SGTC_2899 9053889 58.44 µM -2.15358722290606 0.0202830314646308 no 3279 0.0156362785815009 4732 6470052 SGTC_3203 9113543 49.47 µM -2.15452763158701 0.0202392178212784 no 3280 0.0155994087202613 4703 17018012 SGTC_368 fentichlor 4.58 µM -2.15518189735901 0.0202087829319689 no 3281 0.0155738014667433 4694 7329 A pesticide. SGTC_1759 st043059 70 µM -2.15541592780598 0.0201979058186556 no 3282 0.0155646505323279 4721 669426 SGTC_87 0100-0052 35.5 µM -2.1669292749197 0.0196688916726768 no 3283 0.015120123666386 4710 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1317 1273-0028 910 nM -2.17123180409509 0.0194742419378375 no 3284 0.0149568271870703 4725 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_596 1155-0152 116 µM -2.1777896397505 0.0191807092330674 no 3285 0.0147108507849856 4739 280313 SGTC_1812 st052057 4.327 µM -2.18025233772523 0.0190714529959885 no 3286 0.0146193809775066 4745 3645418 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.19624075607343 0.0183749290134649 no 3287 0.0140373578248609 4731 688664 SGTC_3307 9126885 69.2785 µM -2.20251479295071 0.0181075867929331 no 3288 0.01381448267926 4692 24824909 SGTC_2304 7443016 91.4 µM -2.20800135335906 0.017876524026153 no 3289 0.013622089411583 4688 939854 SGTC_3318 9139014 38.6185 µM -2.21840177350842 0.0174454147685583 no 3290 0.0132637251572591 4717 16643984 SGTC_2384 9036245 200 µM -2.22039933874356 0.0173636377199088 no 3291 0.0131958359520828 4728 6462766 SGTC_1247 0448-0043 5.84 µM -2.22141139277056 0.0173223309894045 no 3292 0.0131615550452325 4703 3089013 YGL099W LSG1 SGTC_1485 3909-9022 254 µM -2.22950510477017 0.0169949977889274 no 3293 0.0128901580190848 4773 714516 SGTC_1920 st075728 45.7 µM -2.23180142520668 0.0169030964591807 no 3294 0.0128140450511639 4707 3400306 SGTC_2598 perillyl alcohol 100 µM -2.23775257275736 0.0166669003096406 no 3295 0.0126185973971893 4704 10819 An apoptosis inducer. SGTC_2412 st077135 33.4 µM -2.24361629379803 0.0164369418506401 no 3296 0.0124285499937018 4711 13258915 SGTC_348 k064-0012 10.7 µM -2.25142375911309 0.0161349757057007 no 3297 0.012179355356022 4715 5066323 SGTC_1626 st003712 1.76 µM -2.25194810789603 0.0161148671317178 no 3298 0.0121627757428067 4717 24207035 SGTC_237 nikkomycin 200 µM -2.26949574121566 0.0154541973587393 no 3299 0.0116190979581554 4742 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1829 berberine 14.4 µM -2.28604270105074 0.0148526402231544 no 3300 0.0111258802858947 4681 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_889 0919-1524 82.7 µM -2.2974899050205 0.0144483629989797 no 3301 0.0107954191456358 4756 3905452 SGTC_913 3487-1245 167 µM -2.3184340824034 0.0137331727599623 no 3302 0.0102128707761735 4700 4016153 SGTC_314 1671-0008 2.74 µM -2.31889857869329 0.0137176639066606 no 3303 0.0102002681111572 4632 3913060 SGTC_1931 st074438 57.1 µM -2.32379185869008 0.0135552003110436 no 3304 0.0100683261488173 4737 2787313 SGTC_2060 5238662 140 µM -2.33886766669854 0.0130650609164153 no 3305 0.00967114167017575 4726 790130 SGTC_1234 0326-0494 15.5 µM -2.35314850734707 0.0126149721548878 no 3306 0.00930759893056354 4769 1547813 SGTC_1936 st074407 74.3 µM -2.35373984179735 0.0125966280638575 no 3307 0.00929280682612432 4744 809813 SGTC_737 1950-0117 57.9 µM -2.36759297820641 0.0121734409843048 no 3308 0.00895211033598922 4748 5393513 SGTC_2483 5729050 27.16 µM -2.37207733050186 0.0120391186482431 no 3309 0.00884419409783913 4727 2865180 SGTC_2750 bromebric acid 70.15 µM -2.38502999891616 0.0116583324107279 no 3310 0.00853886434247677 4741 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2142 5622915 118.518 µM -2.43681379500962 0.0102385473049849 no 3311 0.00740865358054924 4768 5322196 SGTC_749 1000-0129 128 µM -2.43752152444587 0.01022023678795 no 3312 0.00739416688995969 4766 708470 SGTC_1504 k297-0033 30 µM -2.43772493951699 0.0102149792797788 no 3313 0.00739000775736502 4715 4388117 SGTC_1718 roemerine 11.9335 µM -2.44158924762435 0.0101155486941564 no 3314 0.00731138673601535 4439 235224 An aporphine alkaloid with mutagenic activity. SGTC_3272 9137413 49.47 µM -2.45800947861264 0.00970240664587655 no 3315 0.00698547433240725 4742 17614870 SGTC_505 gw-5074 63.9 µM -2.46308127998909 0.00957781361862753 no 3316 0.00688743424632283 4738 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_100 0086-0128 49.5915 µM -2.47171915148125 0.00936883466626981 no 3317 0.00672325531973702 4743 93297 SGTC_982 1491-0518 27.5 µM -2.48403809952798 0.00907770225121962 no 3318 0.00649509544846882 4749 3091256 SGTC_457 grayanotoxin iii 135 µM -2.48792454570384 0.00898751311473512 no 3319 0.00642454954589543 4613 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1410 3909-8106 77.9 µM -2.49456936451474 0.00883513036743055 no 3320 0.00630550377445585 4782 1039210 SGTC_3031 9088762 49.47 µM -2.50706124796358 0.00855478010205748 no 3321 0.00608698074249122 4758 205253 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.51443195192424 0.00839304960709611 no 3322 0.00596121541051358 4763 16623 A steroid. SGTC_176 1486-1328 72.834 µM -2.52532835821365 0.0081588746600077 no 3323 0.00577951154480114 4759 22310231 SGTC_418 lividomycin a 100 µM -2.52679417389594 0.00812781496260572 no 3324 0.00575544707826636 4770 72394 An antibiotic. SGTC_3011 9081274 71.4286 µM -2.52895477862248 0.00808222258481837 no 3325 0.00572013831236784 4766 6625322 SGTC_2708 st078559 56 µM -2.54030524702405 0.00784638198502636 no 3326 0.00553778789163196 4758 17250902 SGTC_1739 st037196 92.5 µM -2.54147115035401 0.00782250309093186 no 3327 0.00551935278505737 4755 612214 SGTC_958 1222-0007 33 µM -2.55690875804089 0.0075123007034486 no 3328 0.00528034569381538 4765 7312461 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.56258871961888 0.00740092475889024 no 3329 0.00519475197734419 4770 7104 SGTC_2819 7996655 46.38 µM -2.62940525900883 0.00619597914632114 no 3330 0.00427671807628514 4757 6456960 SGTC_3029 9088683 49.47 µM -2.65083503378762 0.00584815641707318 no 3331 0.00401465241559693 4770 25236615 SGTC_1712 st032288 53.4 µM -2.67376581930867 0.00549525823180324 no 3332 0.00375024036309875 4656 2883011 SGTC_3170 9103054 49.47 µM -2.68918597201918 0.005268713954759 no 3333 0.00358132515580446 4762 16432970 SGTC_740 k014-0057 261 µM -2.69264114489752 0.00521910638992673 no 3334 0.00354442615567999 4777 4012779 SGTC_645 0845-0943 5.41 µM -2.6941827244216 0.00519710758420969 no 3335 0.0035280734887997 4780 1885106 SGTC_1972 st070201 17.4 µM -2.72679654215418 0.00475063627483353 no 3336 0.00319762293880974 4790 2829099 SGTC_1657 st012939 43.4 µM -2.76297827272378 0.00429562412986414 no 3337 0.00286382895223451 4782 24207257 SGTC_84 0443-0269 128.823 µM -2.79365731924724 0.0039407700925643 no 3338 0.00260578363219714 4778 6150058 SGTC_1276 0871-0068 94.2 µM -2.85985988500526 0.0032630216989562 no 3339 0.00211914110135293 4783 3414906 SGTC_1847 st056231 15 µM -2.86042719101217 0.00325769761327311 no 3340 0.00211535343577453 4774 5393180 SGTC_975 1335-0046 28.5 µM -2.89185604416195 0.00297467409174827 no 3341 0.00191486690346201 4782 16486740 SGTC_1579 chlormadinone acetate 49.4 µM -2.9989355537972 0.00216905003729666 no 3342 0.00135462303520496 4803 45114258 A steroidal progestin. SGTC_342 k048-0088 23.3 µM -3.02416608392819 0.00201067818610188 no 3343 0.00124659763663085 4800 6820570 SGTC_3179 9107801 49.47 µM -3.18869269696416 0.00121042067726694 no 3344 0.000714588599878604 4796 4818259 SGTC_312 4092-0653 6.84 µM -3.19400597512781 0.00119029222151814 no 3345 0.000701566065655198 4753 1148278 SGTC_2167 5876490 200 µM -3.37608239586867 0.000660436234652198 yes 3346 0.000367629481253154 4786 686534 SGTC_2543 pimpinellin 60.67 µM -3.38448310847167 0.000642293691254396 yes 3347 0.000356562033137011 4778 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_458 nppb 133 µM -3.45845180995201 0.000501296468398288 yes 3348 0.000271644727524902 4808 4549 A chloride channel blocker. SGTC_758 0868-0029 16 µM -3.47212154832591 0.000478609850725647 yes 3349 0.000258181244222575 4733 762687 SGTC_310 1273-0058 1.06 µM -3.51633643631179 0.000411579311083783 yes 3350 0.000218773079431357 4575 2734232 SGTC_58 0957-0393 9 µM -3.68937230577147 0.0002244170137701 yes 3351 0.000112404015080827 4579 6997992 SGTC_2812 7970281 58.44 µM -3.94336836696256 8.79597626737616e-05 yes 3352 4.01725497970623e-05 4806 2233435