SGTCid condition conc unit RPN8|YOR261C.score RPN8|YOR261C.strain.pval RPN8|YOR261C.strain.significant RPN8|YOR261C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 5.63120014561957 3.02276836703379e-10 yes 1 8.9479950229705e-09 6 279621 SGTC_2707 st078556 66.6 µM 5.49801418497496 7.57542215606876e-10 yes 2 1.92046020295534e-08 1 17250899 SGTC_1725 st036284 20.55 µM 5.46908624718401 9.22288660677457e-10 yes 3 2.26180800035375e-08 1 707914 SGTC_1729 st035615 45.989 µM 5.07138897462779 1.24824294351841e-08 yes 4 1.97461319756212e-07 5 17385451 SGTC_819 1013-0258 27.7 µM 4.18711793336752 2.10306863794739e-06 yes 5 1.4125952264977e-05 3 5753198 SGTC_1507 4075-3230 155 µM 4.15845216364533 2.44562694219142e-06 yes 6 1.60205656043495e-05 1 659771 SGTC_912 3474-0017 2.18 µM 4.14728567041488 2.59302702113151e-06 yes 7 1.68220086637687e-05 1 3360550 SGTC_2702 st077768 96.8 µM 4.11298273958014 3.1009319593806e-06 yes 8 1.95289799432603e-05 6 6484119 SGTC_634 1611-4317 11.2 µM 4.05672399286579 4.14585129380798e-06 yes 9 2.48829170222234e-05 8 2843522 SGTC_2004 4023728 41.89 µM 3.95231686683826 7.03789892005173e-06 yes 10 3.86990790770395e-05 26 360084 YDR527W RBA50 SGTC_2348 9022543 33.42 µM 3.92167839146117 8.20057291702538e-06 yes 11 4.39671550820182e-05 32 3162678 YDL140C RPO21 SGTC_1797 st048695 56.8 µM 3.78580401083054 1.59450189663255e-05 yes 12 7.66061982301361e-05 17 592262 YIL048W NEO1 SGTC_2415 st077333 57.7 µM 3.77468712829098 1.68206051112558e-05 yes 13 8.01043046536036e-05 18 2766255 SGTC_1556 plumbagin 1.48 µM 3.57812028102426 4.22780574397903e-05 yes 14 0.000173037095865494 22 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3215 9129942 49.47 µM 3.38730068426243 9.9128281877537e-05 yes 15 0.000352919916134158 8 17682944 SGTC_1871 st057448 67.3 µM 3.36032887215692 0.000111440499183935 yes 16 0.000389248711000694 15 691747 SGTC_1082 camptothecin 424.86 nM 3.32150885682515 0.000131700809183545 yes 17 0.000447660703915589 29 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2664 lyso-paf C-16 73.48 µM 3.30836035101497 0.000139312460586846 yes 18 0.000469219870926775 7 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1113 artemisinin 1.17947 µM 3.28355827997952 0.000154804907219426 yes 19 0.000512527239102136 42 2240 An anti-malaria and mitochondrial poison. SGTC_2405 ticlatone 3.52 µM 3.1949804708505 0.000224306848426293 yes 20 0.000699201513867932 30 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1044 1222-0021 1.78 µM 3.14963602397193 0.000270262231780516 yes 21 0.000817369939140607 48 4306703 SGTC_2158 5657123 3.6195 µM 3.14164402834505 0.000279219707590141 yes 22 0.000840010778466664 23 2858827 SGTC_3056 9094900 49.47 µM 3.08202408659564 0.000355293655851028 yes 23 0.00102799100174361 16 25236784 SGTC_444 curcumin 90.4 µM 3.07070670620703 0.000371751436045431 yes 24 0.00106776405071157 29 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1178 0988-0033 191 µM 3.01922332795463 0.000455945259574201 yes 25 0.00126711822390341 14 5392207 SGTC_947 3447-0010 211 µM 3.01318132901898 0.000466908697937255 yes 26 0.00129262197966779 11 748350 SGTC_1500 4488-1866 171 µM 2.98775497751597 0.000515775834146866 yes 27 0.00140517381028357 10 2900003 SGTC_3142 9086498 49.47 µM 2.97249813213449 0.000547327502567835 yes 28 0.00147693503754216 67 25236367 SGTC_501 nsc-95397 161 µM 2.97157999793797 0.000549282034781495 yes 29 0.00148135838699287 15 262093 SGTC_3107 9121808 49.47 µM 2.96545339631116 0.000562490531482098 yes 30 0.00151118566921133 11 662681 SGTC_1318 1280-3875 124 µM 2.95334890995233 0.00058945417086219 yes 31 0.00157173223020183 14 373245 SGTC_1253 0550-0034 176 µM 2.95000755856401 0.000597104880583973 yes 32 0.00158883077681763 21 5969915 SGTC_462 ag-879 158 µM 2.94006717062459 0.000620411209480246 yes 33 0.00164070551055741 28 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_175 3793-3120 23.7 µM 2.87436315116894 0.00079684275197109 yes 34 0.00202421585759597 18 5322297 SGTC_2583 asiatic acid 100 µM 2.86774465462235 0.00081696593685165 yes 35 0.00206704517889795 26 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1552 6-methylflavone 10.6 µM 2.85131029102574 0.000868972887576698 yes 36 0.00217697292647963 22 689013 SGTC_1267 0828-0272 9.49 µM 2.84746788145489 0.000881563463333522 yes 37 0.00220342704100997 14 745334 SGTC_3101 9120531 49.47 µM 2.83728724740293 0.000915737986174583 yes 38 0.00227493290790619 14 24824904 SGTC_1751 st044839 27.194 µM 2.82775710139393 0.000948827906640256 yes 39 0.00234376791418844 11 5291326 SGTC_2085 5307070 144.047 µM 2.81528383412096 0.000993796131498988 yes 40 0.00243670852830268 25 2840351 SGTC_1824 st053723 68.6 µM 2.801311040414 0.00104648799787096 no 41 0.00254477188059476 14 675225 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.78907965904996 0.00109470337512342 no 42 0.00264290310288445 22 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1263 0774-1208 64.8 µM 2.78405309962145 0.0011151015931463 no 43 0.0026842122317834 21 906585 SGTC_609 0986-0026 86.3 µM 2.78369200906591 0.00111658025594954 no 44 0.00268720206342098 26 2848610 SGTC_2357 9067248 200 µM 2.75241232908994 0.0012517039776208 no 45 0.00295789919311405 15 9150235 SGTC_2161 5662504 8.5105 µM 2.74350939718326 0.00129281043546933 no 46 0.00303931541826822 22 2859334 SGTC_3180 9109287 49.47 µM 2.74094225134704 0.00130489062562373 no 47 0.00306316369624837 36 18891271 SGTC_2154 5570129 200 µM 2.73633829424864 0.00132681422735836 no 48 0.00310635604585742 9 673366 SGTC_2393 9031399 185.94 µM 2.73568336053506 0.00132996016641012 no 49 0.00311254470216718 29 1526623 YDL150W RPC53 SGTC_2129 girgensonine 121.053 µM 2.73349137075703 0.0013405389291783 no 50 0.00313333827037819 47 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1098 clofazimine 15.1 µM 2.7329571656226 0.0013431286838593 no 51 0.00313842474003443 52 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_680 0417-1641 114 µM 2.72399578215694 0.00138725944958955 no 52 0.00322486650892662 21 2835990 SGTC_1736 st036774 51 µM 2.71317975513126 0.00144228561986149 no 53 0.00333204731519433 18 1272247 SGTC_2682 pyrogallin 40.03 µM 2.70089206737189 0.00150721144023417 no 54 0.00345768881465658 18 822798 An ATP competetive kinase inhibitor. SGTC_878 0828-0289 13.7 µM 2.68014359287493 0.0016229202510779 no 55 0.00367952923123358 37 745350 YLR208W SEC13 SGTC_941 3237-0776 460 µM 2.67581601586007 0.00164805130976087 no 56 0.00372737781163904 14 760008 SGTC_2782 7736369 71.43 µM 2.66890987759708 0.00168889158483625 no 57 0.00380489329568919 31 2950836 YOL077C BRX1 SGTC_100 0086-0128 49.5915 µM 2.64549429732289 0.00183431498657423 no 58 0.00407858309756018 33 93297 SGTC_2361 9034121 116 µM 2.63640193987226 0.00189378756508462 no 59 0.00418952071778434 47 6496917 SGTC_1058 3448-5425 97.3 µM 2.63628743175338 0.00189454760285411 no 60 0.00419093489875833 33 7279705 SGTC_457 grayanotoxin iii 135 µM 2.62931552569153 0.00194134860469575 no 61 0.00427784685420732 41 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_366 0181-0206 4.31 µM 2.62655725569024 0.00196015245784284 no 62 0.00431267401111374 25 274874 SGTC_211 3455-0679 143.504 µM 2.61003951852978 0.00207626123067013 no 63 0.00452658818349696 18 748649 SGTC_2519 cryptotanshinone 88.04 µM 2.58660672411121 0.00225169462321911 no 64 0.00484630744811143 46 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_161 4065-0411 162.148 µM 2.56954384389949 0.00238777316718895 no 65 0.00509162524785092 39 1906281 YLR208W SEC13 SGTC_503 tyrphostin 8 294 µM 2.55945840444897 0.00247166346683845 no 66 0.00524177004121141 22 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3065 9113888 49.47 µM 2.55241466343604 0.00253182438884538 no 67 0.00534895563181946 28 16648368 SGTC_2421 5690543 90.72 µM 2.50018650642403 0.00302082725375595 no 68 0.006206396947177 27 3397993 SGTC_339 3091-4833 71.4 µM 2.49967994408889 0.00302596057552623 no 69 0.00621527760687033 51 3240077 SGTC_2617 dihydrotanshinone i 20.83 µM 2.46414867157595 0.00340623501595073 no 70 0.00686695656627251 58 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3044 9093193 49.47 µM 2.45840801664315 0.00347155225205549 no 71 0.00697772606463944 38 25236277 SGTC_2452 5863136 48.41 µM 2.45265107383722 0.0035381824853511 no 72 0.00709039092659054 32 2184096 SGTC_1400 3771-8998 51.5 µM 2.44545479422976 0.00362308503603721 no 73 0.00723347917539006 7 670767 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.44205687827092 0.00366380590557033 no 74 0.00730192278127635 35 6728940 SGTC_332 4112-0506 40.9 µM 2.42941150194724 0.00381898077787469 no 75 0.00756167826183456 57 2790355 SGTC_1779 st039427 55 µM 2.42465746869192 0.00387882580701951 no 76 0.0076614182337791 26 1124498 SGTC_1222 0366-0074 1.18 µM 2.4188403195785 0.00395319598973996 no 77 0.00778503671405159 32 286520 SGTC_1246 0422-0085 105 µM 2.41460647171274 0.00400812461465449 no 78 0.00787610918887121 40 264295 SGTC_2001 4023502 57.655 µM 2.41188413915359 0.00404380330537584 no 79 0.00793516192365317 24 108941 YCR052W RSC6 SGTC_2685 mycophenolic acid 18.85 µM 2.40468196058393 0.00413956946250746 no 80 0.00809327288204561 14 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_153 4077-0274 519.67 µM 2.37642330783177 0.00453521806769592 no 81 0.0087406974968457 34 3121976 SGTC_2336 9001819 198.65 µM 2.36067738121356 0.00477002728101001 no 82 0.0091207961019412 82 2989602 SGTC_567 1080-0542 68.4 µM 2.359222683829 0.00479225798446858 no 83 0.00915663138493458 26 5950415 SGTC_2437 5741531 144.16 µM 2.35270752544922 0.00489296014995824 no 84 0.00931864340448222 49 2262990 SGTC_1862 st057513 3.81 µM 2.34628882184049 0.00499401124539001 no 85 0.00948070392331368 35 5393163 SGTC_2790 5423970 71.43 µM 2.34561408426857 0.00500474102506769 no 86 0.0094978821256678 50 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_676 falcarinol 140 µM 2.31664800625774 0.00548516546376202 no 87 0.0102614570080954 43 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2181 6316240 54.2555 µM 2.30855960132757 0.00562644066655621 no 88 0.0104840159486231 26 12779990 SGTC_1602 st001878 87.6 µM 2.30610343732396 0.00566997588897432 no 89 0.0105524266487743 53 595405 YLR310C CDC25 SGTC_2983 9022671 12.99 µM 2.30600890701654 0.00567165738817894 no 90 0.0105550673234152 31 6405161 SGTC_3338 9144300 39.5675 µM 2.30329950721673 0.00572004059590986 no 91 0.0106309986771352 21 4901274 SGTC_1177 0983-0204 23.6 µM 2.28574161398793 0.00604255636467176 no 92 0.0111346895990326 46 766818 SGTC_1945 st075991 56.6 µM 2.28414719370339 0.00607262719354378 no 93 0.0111814408933246 51 1084980 SGTC_1637 st007924 17.4 µM 2.27115529201099 0.00632263889274241 no 94 0.0115687893998766 29 683336 SGTC_1499 4480-0877 67.3 µM 2.2668333548123 0.00640780564228778 no 95 0.011700203851503 24 2861909 SGTC_1105 epirubicin 18.1 µM 2.25743505477196 0.00659651779649363 no 96 0.0119904516815575 51 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_657 3534-0529 86.7 µM 2.24665000819624 0.0068191158903345 no 97 0.0123312017583167 22 1049549 SGTC_881 0833-0569 170 µM 2.23863588766507 0.00698879478679428 no 98 0.0125898085902985 43 5418700 SGTC_20 0481-0013 4.944 µM 2.22641959811788 0.00725461656232842 no 99 0.0129930444814575 59 182045 SGTC_2113 5491891 107.031 µM 2.22436504076414 0.00730018819381612 no 100 0.0130619469757039 44 789979 SGTC_3083 9117465 49.47 µM 2.22200499654706 0.00735284704806719 no 101 0.0131414839661493 37 16420915 SGTC_1562 morin hydrate 59.1 µM 2.20291308662084 0.00779129145146512 no 102 0.0138004375348869 32 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_623 k072-0108 16.9 µM 2.1858592909056 0.00820221546878976 no 103 0.0144129506824449 54 5382803 SGTC_2460 5552655 174.22 µM 2.17979044560697 0.00835297656818377 no 104 0.0146364992458878 51 5401989 SGTC_2481 5478948 45.16 µM 2.16970142748781 0.00860899409798981 no 105 0.0150147359255263 45 77792 SGTC_803 4488-1585 147 µM 2.15612527903255 0.0089643500094794 no 106 0.0155369420418166 34 747204 SGTC_1775 st081588 35.1725 µM 2.14104427212878 0.00937410062497845 no 107 0.0161352340114995 57 1426443 YGL099W LSG1 SGTC_816 0325-0417 81.3 µM 2.13635089530746 0.00950491896174396 no 108 0.0163254116693738 45 68101 SGTC_2563 tomatine 8.54 µM 2.12744221887239 0.00975762603480224 no 109 0.0166916787096392 57 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2447 5741742 33.78 µM 2.12689028410548 0.00977347374852827 no 110 0.0167146001617212 59 1776504 SGTC_1371 2421-0008 32.7 µM 2.10511828846845 0.0104168141499742 no 111 0.0176405063272045 75 2827552 SGTC_314 1671-0008 2.74 µM 2.10223066455248 0.0105048540855411 no 112 0.0177665374362765 59 3913060 SGTC_2124 5246320 200 µM 2.09762387237559 0.0106466516888497 no 113 0.0179691922829164 70 579342 SGTC_919 tnp00227 403.569 nM 2.07944570902457 0.0112225687220862 no 114 0.0187882014738677 62 1269246 A methoxyflavone. YNL221C POP1 SGTC_1681 tripelennamine 100 µM 2.07883170606385 0.0112424853957294 no 115 0.0188164107929296 41 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1198 1612-1005 86.7 µM 2.07465238080596 0.0113788700519265 no 116 0.0190093818494177 54 6998509 SGTC_74 000s-0487 160.283 µM 2.07438535444099 0.0113876326236166 no 117 0.0190217681938371 38 677548 SGTC_3277 9138724 49.47 µM 2.06820484476694 0.0115920930852405 no 118 0.0193103824455519 45 15943418 SGTC_3207 9114163 49.47 µM 2.06620844214985 0.0116588146481403 no 119 0.0194044010333739 63 849233 SGTC_1791 st048313 56.1 µM 2.06097902980678 0.0118351689009097 no 120 0.0196525203669099 32 1204976 SGTC_959 1222-0044 107 µM 2.0497415655794 0.012221982361688 no 121 0.0201948282834121 44 6083612 SGTC_2585 alliin 100 µM 2.04553927975878 0.0123694217501591 no 122 0.0204008604005419 53 87310 A garlic compound which reacts with lipids. SGTC_410 α-linolenic acid 100 µM 2.04156443830007 0.0125102964605182 no 123 0.0205973779227867 46 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1571 st070080 73.4 µM 2.04103164279397 0.0125292847628653 no 124 0.0206238409972229 43 4315245 SGTC_1798 st045719 60.953 µM 2.02916679495964 0.0129586480451467 no 125 0.0212206522016237 45 3980186 SGTC_1574 spiramycin 23.7 µM 2.02830337502572 0.0129903841126236 no 126 0.0212646473653072 58 6419898 An antibiotic and protein synthesis inhibitor. SGTC_977 1348-1378 135 µM 2.02219389362545 0.0132168715370683 no 127 0.021578162440765 50 X977 SGTC_1713 st033146 12.748 µM 2.01198380045039 0.0136029919350893 no 128 0.0221108223354192 52 674619 SGTC_1293 1000-1278 195 µM 2.00766566077511 0.0137691997189448 no 129 0.0223394160057344 60 678847 SGTC_2948 9070189 9.45 µM 2.0027493497547 0.0139605612425504 no 130 0.0226020994504906 37 6473636 YDL196W YDL196W SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.0010851020825 0.0140258574527615 no 131 0.022691609774971 54 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3058 9093861 49.47 µM 1.99840751257005 0.0141314642547831 no 132 0.0228362489147007 59 17217477 SGTC_702 1488-0190 94 µM 1.98680625521764 0.0145969817472543 no 133 0.0234719355890301 31 949357 SGTC_1271 0832-2808 169 µM 1.98525111063033 0.014660376331646 no 134 0.023558270202545 69 3663794 SGTC_967 1306-0166 352 µM 1.98340249496467 0.014736042116372 no 135 0.023661244333824 58 4437607 SGTC_3346 9158254 43.5805 µM 1.97912312763076 0.0149124910708185 no 136 0.0239010725722137 74 17639500 SGTC_2164 5685496 200 µM 1.97469985549183 0.0150967796962382 no 137 0.0241511096752455 39 759046 SGTC_1678 st019265 80.2 µM 1.96795098267492 0.0153817306683378 no 138 0.0245368389528108 46 5367020 SGTC_2370 9071495 200 µM 1.95404056068465 0.0159836517939381 no 139 0.0253482102872762 60 21791103 SGTC_152 4469-0003 551.229 µM 1.93477328489762 0.0168506475325754 no 140 0.0265090613817413 97 697280 SGTC_2125 5246583 200 µM 1.93046418104901 0.0170499612395788 no 141 0.0267746746141105 60 835267 SGTC_3028 9087778 49.47 µM 1.93003530839352 0.0170699081705446 no 142 0.0268012315109974 51 17217395 SGTC_3117 9124945 49.47 µM 1.92543954066347 0.0172849130147258 no 143 0.027087196437433 37 17592065 SGTC_2354 9060492 162 µM 1.91571480449446 0.0177475037172305 no 144 0.0277007034914599 47 6471895 SGTC_882 0843-0131 351 µM 1.91562426596418 0.0177518596455962 no 145 0.0277064692809669 80 5425421 SGTC_3355 9151058 44.0485 µM 1.91552053998979 0.0177568511604192 no 146 0.0277130761192266 54 17015728 SGTC_88 0180-0332 8.668 µM 1.91055026076217 0.0179974390196483 no 147 0.0280312007679396 63 3101745 SGTC_2497 7-hydroxyflavone 100 µM 1.90537419887885 0.0182509367137835 no 148 0.0283657233111138 68 5281894 SGTC_1142 3253-1408 9.78 µM 1.89621691954505 0.0187068692296631 no 149 0.0289656833884576 44 256655 SGTC_2797 7859098 81.82 µM 1.88623707625444 0.0192147599876068 no 150 0.0296315071731162 62 972681 SGTC_3024 9090631 49.47 µM 1.88487984197681 0.0192847290940555 no 151 0.0297230311152101 39 25236383 SGTC_942 3253-1115 227 µM 1.87975223246838 0.0195510288040336 no 152 0.0300709266570598 65 46497897 SGTC_843 0310-0051 143 µM 1.87592079722803 0.019752045288357 no 153 0.0303330782071869 50 2065037 SGTC_817 1391-0715 46 µM 1.87466255461447 0.0198184405801376 no 154 0.0304195807208458 82 1353946 SGTC_1060 3448-7350 82 µM 1.87385943416867 0.0198609188224866 no 155 0.0304749009746241 73 570178 SGTC_283 0987-0079 11.7 µM 1.87288961998597 0.0199123167071686 no 156 0.0305418144247205 44 411556 SGTC_553 k007-0256 45.7 µM 1.86798964461971 0.02017373287082 no 157 0.0308817571723477 76 6287000 SGTC_2218 6965428 192.983 µM 1.86475756409169 0.0203477542210118 no 158 0.0311076969893519 45 675684 SGTC_1903 st060211 78.3 µM 1.85795158463735 0.0207183647669002 no 159 0.0315879449879482 62 688960 SGTC_965 1291-5240 308 µM 1.85520953647008 0.0208692866151357 no 160 0.0317831551965734 65 2834598 SGTC_1672 st016598 6.51 µM 1.85261348655188 0.0210130293710405 no 161 0.0319688890050441 84 4665860 YNL267W PIK1 SGTC_3178 9107506 49.47 µM 1.84980257571698 0.0211696127628233 no 162 0.0321710047501482 84 8897194 SGTC_2955 9076254 12.21 µM 1.82829429303311 0.0224007228070673 no 163 0.0337526979373837 60 16459619 SGTC_378 3970-0959 8.33 µM 1.81684487392013 0.0230803457511368 no 164 0.0346204347697129 67 6615653 SGTC_2139 5578692 56.4705 µM 1.81187783862535 0.0233805380994569 no 165 0.0350025371860188 82 650991 YMR113W FOL3 SGTC_190 3970-0790 3.722 µM 1.80917257455461 0.0235454134475478 no 166 0.0352120984674317 54 2832352 SGTC_1315 1237-0019 3.69 µM 1.80352782517856 0.0238925899184026 no 167 0.0356526797830969 60 825140 SGTC_2176 5809774 33.9695 µM 1.80170354570291 0.0240057068962972 no 168 0.0357960299711558 38 2870539 SGTC_2450 5739737 12.93 µM 1.80023445434442 0.0240971267436081 no 169 0.0359118128107586 59 2262825 SGTC_1702 st027038 51 µM 1.79985363312196 0.0241208724845016 no 170 0.0359418763234428 59 5521182 SGTC_731 3966-0296 387 µM 1.79902969527194 0.0241723156145625 no 171 0.0360069917495297 54 660956 SGTC_3286 9117135 37.221 µM 1.7921703827243 0.0246041690233467 no 172 0.0365528386755002 64 3438150 SGTC_2002 4023503 131 µM 1.7858192750953 0.0250097808793556 no 173 0.0370642623844489 85 4736863 YCR052W RSC6 SGTC_2466 5983409 37.09 µM 1.76823127530834 0.0261623886604809 no 174 0.0385111238489306 73 2879657 SGTC_896 0964-0007 44.5 µM 1.76155419844734 0.0266114422404002 no 175 0.0390723240935763 77 6756758 SGTC_1422 4031-0024 15.5 µM 1.75864414948843 0.0268091567738514 no 176 0.0393189845795476 76 782427 SGTC_989 1501-0895 10.3 µM 1.75493315137922 0.0270630673741815 no 177 0.0396353714170922 56 2830112 SGTC_1116 jasmonic acid  1.58368 µM 1.75364296597235 0.0271518121133048 no 178 0.0397458519715559 57 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2375 9072683 200 µM 1.74131704385976 0.0280119479172341 no 179 0.0408140101288894 69 16798029 SGTC_847 0342-0274 5.54 µM 1.73815308007176 0.0282363616078781 no 180 0.041091922027793 79 18097 SGTC_3293 9120939 62.045 µM 1.73420354018284 0.0285185926849231 no 181 0.0414409875268649 71 934087 SGTC_770 0389-1121 67.2 µM 1.72394951330617 0.0292623095645273 no 182 0.0423584788652885 72 6753108 SGTC_2626 ethyl orsellinate 100 µM 1.72133357653302 0.0294545993156595 no 183 0.0425951549853863 101 75653 A natural product. SGTC_1804 st050076 49.1 µM 1.71879829253655 0.0296419603926178 no 184 0.0428255532787911 84 3895976 SGTC_284 0988-0104 32.6 µM 1.716973770863 0.0297774062552798 no 185 0.042991982257388 67 4666532 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.71657900220712 0.0298067799146377 no 186 0.0430280608905431 79 688803 SGTC_1828 st055811 49 µM 1.70810776974707 0.0304429157870826 no 187 0.0438081737447641 38 5877589 SGTC_3048 9093155 49.47 µM 1.69917920691957 0.0311255275893217 no 188 0.0446427114636927 64 25236002 SGTC_1227 3909-8010 46.6 µM 1.69774453978391 0.0312363835573883 no 189 0.044777993722388 55 15982272 SGTC_3069 9117009 49.47 µM 1.69155493710781 0.031718400773611 no 190 0.0453654323414578 49 41904981 SGTC_401 neomycin 50 µM 1.68907112160523 0.0319135489372188 no 191 0.0456029006178704 64 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_751 0833-0568 350 µM 1.68603007062186 0.032153827152726 no 192 0.0458950038061817 69 6954252 SGTC_2172 5754775 163.918 µM 1.68037785946757 0.0326043843548637 no 193 0.046441910503019 104 2263357 SGTC_800 3448-7362 155 µM 1.67754329261157 0.032832290423407 no 194 0.0467181455679559 140 15991913 SGTC_1701 st028638 40.4 µM 1.67729050812723 0.0328526785340568 no 195 0.0467428438830865 57 3490878 SGTC_2597 laccaic acid a 100 µM 1.67456056897577 0.0330735250323405 no 196 0.0470102406094575 83 5491415 A textile dye. SGTC_546 peri-Naphthalide 147 µM 1.67159879780163 0.0333145082463272 no 197 0.0473017310026913 112 223824 A penicillin ester. SGTC_2000 st075254 36.4 µM 1.66629060990275 0.0337500242001385 no 198 0.0478277730485529 65 17234175 SGTC_123 0083-0120 66.675 µM 1.66245931152654 0.0340672692648481 no 199 0.0482103575588696 92 16001701 SGTC_2187 6125751 200 µM 1.66239700685608 0.0340724485045848 no 200 0.0482165993311734 80 874498 SGTC_2709 st078560 56 µM 1.66098313169052 0.0341901547590106 no 201 0.0483584172862015 93 17250903 SGTC_3111 9122088 49.47 µM 1.65938260048512 0.0343238034492545 no 202 0.0485193600723552 61 16876704 SGTC_1479 0549-0158 134 µM 1.65737824286681 0.0344917779474523 no 203 0.0487215136809107 78 5440202 SGTC_2464 5717415 7.67 µM 1.65604753737912 0.0346036698438 no 204 0.0488560961706728 68 5285744 SGTC_1587 estradiol valerate 56.1 µM 1.64421955173278 0.0356113805690271 no 205 0.0500654298638073 90 13791 A steroid. SGTC_50 0929-0078 56.389 µM 1.64016428680454 0.035962366656904 no 206 0.0504855063386853 64 1377751 SGTC_1878 temozolomide 1 mM 1.63993665245148 0.0359821522722332 no 207 0.0505091694967343 74 5394 DNA alkylating agent. SGTC_1644 st010134 20.9 µM 1.63873884182296 0.036086411013392 no 208 0.0506338305070904 73 3818134 SGTC_3210 9128157 49.47 µM 1.63840682765349 0.0361153536379202 no 209 0.0506684279112264 86 17590849 SGTC_3043 9092303 49.47 µM 1.63828944634984 0.036125590648865 no 210 0.050680664087106 70 25236084 SGTC_490 phenamil 164 µM 1.63671777554879 0.0362628876070357 no 211 0.0508447265356063 72 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3233 9132340 49.47 µM 1.63657389876892 0.0362754776114127 no 212 0.0508597665444721 105 17682950 SGTC_735 3076-0345 636 µM 1.63626216747845 0.0363027680780315 no 213 0.0508923652002025 74 2888990 SGTC_744 1594-0068 283 µM 1.62912005325947 0.0369326404248726 no 214 0.0516438034200499 88 668392 SGTC_1446 4239-0190 62 µM 1.62790598912351 0.0370405936277774 no 215 0.0517724106510275 91 1340085 SGTC_3119 9125183 49.47 µM 1.61505217324109 0.0381994354069539 no 216 0.0531496984470004 53 22695334 SGTC_945 3381-0768 11.3 µM 1.61277001465256 0.0384082431021834 no 217 0.053397241453084 85 1126236 YIL048W NEO1 SGTC_341 1486-1430 230 µM 1.6071078847157 0.0389303234280773 no 218 0.0540153519856663 122 2054753 YPL210C SRP72 SGTC_2968 9090663 33.37 µM 1.60134608345963 0.0394675118056062 no 219 0.0546501437138953 128 25236811 SGTC_720 r052-1644 49.9 µM 1.60040795768557 0.0395555439720701 no 220 0.0547540554589996 94 1422863 YOR257W CDC31 SGTC_271 rotenone 740 µM 1.60009822275453 0.0395846440284556 no 221 0.0547883976057196 69 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_330 1488-0319 80.1 µM 1.59915965489694 0.0396729302021923 no 222 0.0548925661609717 102 6846614 SGTC_2215 7188065 200 µM 1.59707434159717 0.0398696578375845 no 223 0.0551245684330213 64 940217 SGTC_386 1509-0011 3.07 µM 1.59453336324352 0.040110443721468 no 224 0.0554083121369121 75 3107280 SGTC_2045 5106652 78.05 µM 1.58576747562015 0.0409501911987784 no 225 0.0563960331119178 64 673349 SGTC_2223 6903751 107.57 µM 1.57934876563937 0.0415740850948801 no 226 0.0571280410701607 75 5598863 SGTC_931 2812-0076 566 µM 1.57658540611184 0.0418450424339362 no 227 0.0574454764651991 96 3450959 SGTC_1230 0170-0365 3.77 µM 1.57620843670679 0.0418821162319466 no 228 0.0574888874223916 109 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1692 fluoroquinolonic acid 71 µM 1.57495481421122 0.042005597523692 no 229 0.0576334374226547 65 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.57108238007157 0.0423888928549741 no 230 0.0580817573941212 95 616764 SGTC_23 0213-0011 39.996 µM 1.57083173069366 0.0424137994155822 no 231 0.058110869773663 94 627608 SGTC_1660 st012960 28.1 µM 1.56238471196104 0.0432601082113976 no 232 0.0590986932124754 79 24207266 SGTC_1086 cerivastatin 2.18 µM 1.55885811238741 0.0436174506386999 no 233 0.0595149831599926 81 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_206 4546-0025 72.014 µM 1.55605068450891 0.0439036207455566 no 234 0.0598480202385411 94 6620745 YIL048W NEO1 SGTC_11 0438-0307 1.3 µM 1.55262701029791 0.0442546541779498 no 235 0.0602561344707645 108 4011476 SGTC_333 3486-0131 40.1 µM 1.52855072448785 0.0467875573921845 no 236 0.0631879297910665 98 6744690 SGTC_3124 9127567 49.47 µM 1.52535359049785 0.0471324841022264 no 237 0.0635854638636579 72 17592030 SGTC_2200 6600604 21.907 µM 1.52220509734989 0.0474741524560353 no 238 0.0639788491562785 103 2904777 SGTC_1640 st009078 66.4 µM 1.52203203227578 0.0474929905257079 no 239 0.0640005273461588 101 690618 SGTC_2211 7117706 200 µM 1.52161260395167 0.0475386699885651 no 240 0.0640530887741977 79 822771 SGTC_70 0141-0289 43.283 µM 1.52078480713706 0.047628927674422 no 241 0.0641569241255699 106 352408 SGTC_934 2950-0684 338 µM 1.51922941540503 0.0477988888617172 no 242 0.0643523797757357 102 1121253 SGTC_3012 9080433 71.4286 µM 1.51353085963246 0.0484257355094476 no 243 0.065072434282316 107 17688859 SGTC_1273 0849-0096 14.1 µM 1.5131514779917 0.0484677001820073 no 244 0.0651205930587335 110 5286025 SGTC_1176 0848-0131 83.3 µM 1.51091010222908 0.0487162200090719 no 245 0.065405678325446 95 6769040 SGTC_600 1495-0418 41.6 µM 1.5068794036659 0.04916569879338 no 246 0.0659207858291867 113 5377768 SGTC_416 estradiol valerate 100 µM 1.50261138757034 0.0496452457571279 no 247 0.0664696425674857 103 13791 A steroid. SGTC_126 0417-1624 672.48 µM 1.50110225998516 0.0498156992095389 no 248 0.066664557190319 130 41912 YDL195W SEC31 SGTC_1634 st006576 41 µM 1.50062472791778 0.0498697327902727 no 249 0.0667263259160003 95 3915356 SGTC_1873 rapamycin 2 nM 1.49856289659301 0.0501035694398113 no 250 0.0669935321431489 86 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1 0258-0098 57.368 µM 1.49404086305194 0.050619483835644 no 251 0.0675824695658602 111 6790032 YDR047W HEM12 SGTC_3282 9108498 15.4605 µM 1.48881370911616 0.0512211076078081 no 252 0.0682682156464131 109 16459645 SGTC_2854 9024559 71.43 µM 1.48523704533091 0.0516360350360927 no 253 0.0687405209553778 86 3163529 SGTC_1358 1509-0022 2.48 µM 1.48232559025568 0.0519757610681788 no 254 0.0691268411914792 110 3258434 SGTC_400 oxethazaine 37.5 µM 1.48201426765348 0.052012192914271 no 255 0.0691682493241624 97 4621 A local anesthetic. SGTC_1611 st001856 99.4 µM 1.48132472009402 0.052092957940958 no 256 0.0692600321242812 113 647478 SGTC_933 2914-0560 114 µM 1.47518424454978 0.0528165780125261 no 257 0.0700815080567213 93 463887 SGTC_2584 androsterone 48.74 µM 1.47266698571987 0.0531155175414061 no 258 0.0704204264123185 124 2754130 A steroid. SGTC_594 1487-1584 10.8 µM 1.4712366320511 0.0532859773715935 no 259 0.0706135668374904 107 5013332 SGTC_1656 st012921 11 µM 1.46977913156624 0.053460118113453 no 260 0.0708107914225998 96 6732821 SGTC_1157 4092-0394 27.6 µM 1.46898044886033 0.0535557350327604 no 261 0.0709190461207156 88 3659885 SGTC_2473 5854593 8.94 µM 1.46455232766802 0.0540883223886694 no 262 0.0715215482814402 108 2872951 SGTC_1395 3486-0190 4.35 µM 1.463848066498 0.0541734116696132 no 263 0.0716177329187287 103 6748079 SGTC_1219 1469-0211 33.1 µM 1.46166386419844 0.0544379822394355 no 264 0.0719166721003741 100 6822282 SGTC_831 k061-1017 217 µM 1.46150145326512 0.0544576956895777 no 265 0.0719389385107724 118 1240153 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.45440126405213 0.0553250496472561 no 266 0.0729175448546815 65 4000243 SGTC_1284 0929-0043 16 µM 1.45403217459693 0.0553704339350466 no 267 0.0729686930587349 96 1239883 SGTC_1119 parthenolide 318.541 nM 1.45222898127255 0.0555925825067502 no 268 0.0732189734414595 114 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1645 Cervolide 78 µM 1.45090135496768 0.0557565917074648 no 269 0.073403665284501 104 23173 A fragrance. SGTC_663 1486-0733 13.9 µM 1.44965253652498 0.0559112135882534 no 270 0.0735777188442052 106 722445 YPR165W RHO1 SGTC_683 panaxydol 45 µM 1.44772056325394 0.0561510861820276 no 271 0.0738476083014525 73 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1900 st060200 72.8 µM 1.44561426408208 0.0564135268167793 no 272 0.0741427117905862 109 688945 SGTC_290 2043-6722 48.1 µM 1.44524886762041 0.0564591527258742 no 273 0.0741939972991199 95 773758 YLR208W SEC13 SGTC_3055 9094636 49.47 µM 1.43868078561258 0.0572842580551344 no 274 0.0751204928680941 129 25236176 SGTC_1020 4335-0961 93.3 µM 1.43384949709003 0.0578972159157337 no 275 0.0758076082361075 107 669075 SGTC_2720 fluspirilene 36.88 µM 1.43043106014554 0.0583340276310278 no 276 0.0762966695077629 95 3396 An atypical antipsychotic. SGTC_2373 9071805 200 µM 1.42331027617854 0.0592522383391066 no 277 0.0773231146666913 95 10149009 SGTC_1050 3232-1156 69.3 µM 1.41910719311311 0.0597995133676639 no 278 0.0779338835830074 119 700529 SGTC_807 1315-0151 48 µM 1.41579563891785 0.060233486878404 no 279 0.0784176734111832 143 4011080 SGTC_2289 7946404 165.07 µM 1.41496237953807 0.0603430713697638 no 280 0.0785397633040183 132 1246120 YPR165W RHO1 SGTC_894 0960-0238 55.9 µM 1.41191877813108 0.0607446710078993 no 281 0.0789869389598828 122 6741907 YDL195W SEC31 SGTC_2871 9038510 12.99 µM 1.41146916039276 0.0608041743353372 no 282 0.0790531613943714 132 4945164 SGTC_1373 2887-0003 58.5 µM 1.40862728462831 0.0611813290944294 no 283 0.0794727032928141 129 776948 SGTC_3204 9114183 49.47 µM 1.40541664337064 0.0616096206254953 no 284 0.0799487102399369 110 17027248 SGTC_530 4358-1714 28 µM 1.40487448429111 0.0616821737888703 no 285 0.0800293026046159 125 1564641 SGTC_2287 7945887 168.79 µM 1.40269856994819 0.0619740317202232 no 286 0.0803533719734274 123 1245853 SGTC_1769 st044406 64.4 µM 1.39703245609338 0.0627390915256828 no 287 0.0812019056706729 145 670903 SGTC_1124 fisetin 1.16336 µM 1.3884169796879 0.063916464358841 no 288 0.0825050544464886 106 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1238 0333-0287 48.8 µM 1.38802859070263 0.0639699428075973 no 289 0.082564169617888 108 7226 SGTC_273 hydroxyurea 18.1 mM 1.38448850433152 0.0644589931688648 no 290 0.0831044628271198 136 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1723 st034307 2.5525 µM 1.38400727740746 0.0645256966345924 no 291 0.0831781132068226 137 867466 SGTC_1651 st011928 86.1 µM 1.38279807027629 0.0646935430017752 no 292 0.083363395431938 111 720198 SGTC_747 3448-8087 38.7 µM 1.38018129646883 0.0650579301031033 no 293 0.0837654156255279 106 5168703 SGTC_575 k072-0246 11.9 µM 1.37589717524098 0.0656579323571114 no 294 0.084426734949534 116 6796779 SGTC_3073 9114972 49.47 µM 1.37227495752877 0.066168572799755 no 295 0.0849889292037939 90 41905075 SGTC_1495 4469-0029 237 µM 1.37214937002869 0.0661863324602996 no 296 0.0850084714986473 108 793680 SGTC_2053 5265679 138 µM 1.37049831226623 0.0664201563809926 no 297 0.0852657009408462 130 764595 SGTC_1913 st060213 96.1 µM 1.3686958004934 0.0666761590429663 no 298 0.0855471917893965 119 688959 SGTC_1427 4048-4900 550 nM 1.36570500536557 0.0671026120592389 no 299 0.0860157863320543 120 24132586 SGTC_2828 7998861 71.43 µM 1.36437117471435 0.0672934797636665 no 300 0.086225387664071 75 2988188 SGTC_1251 0490-5699 265 µM 1.36403320330686 0.0673419091776536 no 301 0.0862785579105573 125 3883818 SGTC_428 3448-4153 16.5 µM 1.36363750423435 0.0673986448756835 no 302 0.0863408411301307 109 3834874 SGTC_2665 lovastatin 100 µM 1.36359135291915 0.0674052644989201 no 303 0.0863481075576542 113 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_3019 9081971 49.47 µM 1.36348353635666 0.0674207309139789 no 304 0.0863650848307565 103 16451803 SGTC_1160 4092-0570 10.5 µM 1.36181369810709 0.0676606215646713 no 305 0.0866283437373081 127 4994975 SGTC_1064 honokiol 6.76 µM 1.36072413441058 0.0678175045501705 no 306 0.0868004423417966 135 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_558 k064-0027 21.3 µM 1.35456792864235 0.0687092015587385 no 307 0.0877776286664708 126 5088526 SGTC_3354 9151612 71.43 µM 1.35400191017551 0.0687916383694853 no 308 0.0878678841505741 104 27261949 SGTC_621 3584-0052 32.1 µM 1.35265386346607 0.0689882794520041 no 309 0.0880831180383402 123 2273927 SGTC_694 1315-0438 43.2 µM 1.34401520473467 0.0702587097296991 no 310 0.0894717351021152 97 6793154 SGTC_879 0831-1030 162 µM 1.34274073948516 0.0704476501788892 no 311 0.0896779690700029 152 1549252 SGTC_446 go6976 132 µM 1.34272877028889 0.0704494264710841 no 312 0.0896799075991771 110 3501 A protein kinase C inhibitor. SGTC_2310 7668677 200 µM 1.33869406856787 0.071050161979174 no 313 0.090335144013028 156 2197143 SGTC_1829 berberine 14.4 µM 1.33614565300181 0.071431623414927 no 314 0.0907508352794041 141 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2461 5755302 26.15 µM 1.33137372387371 0.0721501377211096 no 315 0.0915330354528594 115 2788904 SGTC_584 0986-0246 15.4 µM 1.32990859786689 0.0723718511775261 no 316 0.0917741941269247 160 53315 YDR232W HEM1 SGTC_2544 sphondin 68.51 µM 1.3213389526346 0.073679141776692 no 317 0.0931941856792756 145 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3315 9136395 68.55 µM 1.31958835813985 0.0739484000907782 no 318 0.0934862459389329 159 16876844 SGTC_2533 agelasine 13.65 µM 1.31777173551931 0.074228608446498 no 319 0.0937900361562459 127 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1766 st045414 44.774 µM 1.31696080006672 0.0743539541860994 no 320 0.0939258823077199 130 253960 SGTC_1374 2889-5571 141 µM 1.31478643513488 0.0746908419184951 no 321 0.0942908437964461 166 2853281 SGTC_2344 7990960 76.95 µM 1.31445830575226 0.0747417820155716 no 322 0.0943460101632981 153 140813 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.31435841501635 0.0747572947089447 no 323 0.0943628089009857 126 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2307 7538926 6.34 µM 1.31401710919669 0.0748103168857506 no 324 0.0944202233295528 149 96582 SGTC_863 0466-0191 129 µM 1.31359427765383 0.0748760439445335 no 325 0.0944913877249049 140 765160 YPR165W RHO1 SGTC_2044 5102272 200 µM 1.31109131597828 0.0752660194183833 no 326 0.0949134571551102 123 592666 SGTC_2320 7373003 200 µM 1.31027844434878 0.0753930019056889 no 327 0.0950508284248908 119 5415828 SGTC_1490 4089-0339 670 nM 1.30914509872582 0.0755703195899146 no 328 0.0952426025616467 125 742542 SGTC_2128 5255449 168.493 µM 1.30793181355525 0.0757604962015683 no 329 0.0954482189091193 111 736008 SGTC_647 0140-0236 81 µM 1.30225101418856 0.0766557863338884 no 330 0.0964152956465946 119 990837 SGTC_595 3909-8003 73.7 µM 1.29859722965872 0.0772358578640824 no 331 0.0970410946067987 124 699517 SGTC_869 0564-0080 44.1 µM 1.29837238340593 0.0772716628816251 no 332 0.097079702120752 101 6843321 SGTC_2619 obliquin 87.91 µM 1.29804149181676 0.0773243777255369 no 333 0.097136538786436 135 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2488 5268135 45.7 µM 1.29634417773692 0.077595208958829 no 334 0.0974284673861996 138 1270356 YLR208W SEC13 SGTC_708 3448-5400 146 µM 1.29511928301423 0.0777911057908363 no 335 0.0976395419236834 165 3462195 SGTC_2279 7948423 32.93 µM 1.29354534545426 0.0780433756568809 no 336 0.0979112557016064 115 1247112 SGTC_308 4092-1169 104 µM 1.29157902739708 0.078359407509311 no 337 0.0982514854562728 142 2268590 YDL196W YDL196W SGTC_3252 9135871 49.47 µM 1.28900681656416 0.0787742838112638 no 338 0.0986978583968236 120 17682838 SGTC_117 lucigenin 22.078 µM 1.28556610219318 0.0793318419823944 no 339 0.0992972666785419 127 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3021 9087658 49.47 µM 1.27487977807646 0.0810825806373747 no 340 0.101175898811093 99 25237042 SGTC_2451 5856223 45.7 µM 1.26625806754831 0.0825162008834402 no 341 0.102710352136616 154 2179896 SGTC_2932 9016711 44.54 µM 1.26420605926329 0.0828602038631126 no 342 0.103078038289508 131 7117328 SGTC_1760 st045453 10.4495 µM 1.25407538359008 0.0845743585986909 no 343 0.104907303402007 137 3323419 YIL048W NEO1 SGTC_234 nsc-17383 10.7 µM 1.25382663081516 0.0846167807505767 no 344 0.104952513679334 134 408974 SGTC_514 4466-0038 2.65 nM 1.25313252122332 0.0847352381917361 no 345 0.105078741176988 158 5722064 SGTC_3010 9080089 71.4286 µM 1.25206267964705 0.0849180619194968 no 346 0.105273512657502 114 17027233 SGTC_2382 9035899 200 µM 1.2513798734913 0.0850349002019076 no 347 0.105397958348894 145 6462679 SGTC_1973 st070275 50.2 µM 1.25083339298231 0.0851284979132575 no 348 0.105497634477074 98 17118334 SGTC_84 0443-0269 128.823 µM 1.24979427062593 0.085306685129348 no 349 0.105687354780607 134 6150058 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.24627107104128 0.0859129182209306 no 350 0.106332447340419 120 140250 A respiratory chain inhibitor. SGTC_440 fluspirilene 35.1 µM 1.24624669780436 0.0859171232972023 no 351 0.106336919925441 132 3396 An atypical antipsychotic. SGTC_2057 5236571 38.335 µM 1.24573796545806 0.0860049292529898 no 352 0.106430305329869 128 54684039 YBR257W POP4 SGTC_285 1486-1325 46 µM 1.24124980153279 0.0867824864804589 no 353 0.10725674124609 147 22310230 SGTC_1590 st077108 57.8 µM 1.24089676067217 0.0868438715894406 no 354 0.107321944790383 117 5489485 SGTC_2292 7671323 168.05 µM 1.24046360282351 0.0869192313825027 no 355 0.107401984271144 174 937504 SGTC_996 3970-0799 1.8 µM 1.23946304484516 0.0870934928689698 no 356 0.107587033162676 162 6615648 YGL040C HEM2 SGTC_1355 1499-0035 1.68 µM 1.2367729747032 0.0875633006923247 no 357 0.108085688959469 127 1548538 SGTC_789 1309-1135 70.6 µM 1.23491156462131 0.0878894923351071 no 358 0.108431709477239 125 3092424 SGTC_408 cantharidin 100 µM 1.23399845616481 0.0880498354810738 no 359 0.108601739761438 132 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_398 bronopol 33.3 µM 1.23284267328286 0.0882531052300117 no 360 0.108817233437628 150 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_362 0310-0100 9.03 µM 1.23271194000989 0.0882761195414784 no 361 0.108841627766612 115 790235 SGTC_2936 9038235 15.59 µM 1.2290946466012 0.0889146839777686 no 362 0.109518161043997 140 4749415 SGTC_2546 rhodinyl acetate 100 µM 1.22870338303823 0.0889839596992621 no 363 0.10959151867119 149 6708682 SGTC_2152 5568786 200 µM 1.22777997044647 0.0891476151100347 no 364 0.109764788281571 148 5399883 SGTC_424 splitomicin 100 mM 1.22647192334493 0.0893798220961008 no 365 0.110010567340961 141 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_780 0109-0199 192 µM 1.22518815597886 0.0896081560790273 no 366 0.110252167988677 154 610414 SGTC_3016 9080866 49.47 µM 1.22425777043719 0.0897739075928881 no 367 0.110427501050881 135 17066299 SGTC_1024 4507-0395 26 µM 1.22342044168214 0.089923275470152 no 368 0.110585468212535 136 4201836 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.21917826018436 0.0906828611061974 no 369 0.111388270690208 130 803109 SGTC_615 k087-0205 167 µM 1.21745600636001 0.0909925954301901 no 370 0.111715382580024 147 9642773 SGTC_1765 st044815 90.4 µM 1.21693126862612 0.0910871213401342 no 371 0.111815183747362 157 645695 SGTC_1904 st060225 78 µM 1.21603131826725 0.0912494073359027 no 372 0.111986495963885 132 66595 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.21549991153108 0.0913453353165779 no 373 0.112087741251897 174 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1509 1326-1131 80 µM 1.21421911402478 0.0915768483210772 no 374 0.112332031704316 118 768313 SGTC_1193 1488-0126 41.5 µM 1.21403805843403 0.0916096104172678 no 375 0.112366595662592 136 1384710 SGTC_2507 purpurin 79.67 µM 1.21221420462558 0.0919401221647654 no 376 0.112715197723566 138 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2764 methyldopa 94.69 µM 1.21108918989508 0.0921444328696903 no 377 0.112930611987256 128 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_478 N-arachidonylglycine 10 µM 1.20451905599729 0.0933443331350778 no 378 0.114194510629921 85 5283389 SGTC_2335 9018011 154.17 µM 1.20246524843911 0.0937217769366197 no 379 0.114591661232459 144 6458208 SGTC_1982 st072467 71.9 µM 1.19609379144472 0.0948998765153491 no 380 0.115829980084936 153 3163533 SGTC_1938 st074717 56.4 µM 1.19517355808993 0.0950709279070241 no 381 0.116009613613701 138 17250979 SGTC_1720 st037298 9.481 µM 1.19012371446508 0.0960136277691249 no 382 0.11699888538433 155 597396 SGTC_3318 9139014 38.6185 µM 1.18859769649825 0.0962998512540606 no 383 0.117299007381351 156 16643984 SGTC_3261 9137475 49.47 µM 1.18804986319005 0.096402756971504 no 384 0.117406882670266 81 17027690 SGTC_997 3996-0078 137 µM 1.18719539859617 0.0965634219768546 no 385 0.117575277734124 149 735687 SGTC_1742 st038235 28.8875 µM 1.18338543209477 0.0972822044216155 no 386 0.118328214089747 159 564103 YBR002C RER2 SGTC_862 0452-0056 10.2 µM 1.18304467219567 0.0973466824090165 no 387 0.11839572172187 124 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2592 piperlongumine 83.33 µM 1.18246163585371 0.0974570762210942 no 388 0.118511289650216 154 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1296 1068-0102 11.9 µM 1.18176219843799 0.0975896308738713 no 389 0.118650035453096 132 767053 SGTC_644 1498-1197 63.3 µM 1.17820605642004 0.0982656223542156 no 390 0.11935723433934 148 6741615 SGTC_2763 lisinopril 49.32 µM 1.17557206988579 0.0987685266448187 no 391 0.119882960996585 139 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2027 5150920 200 µM 1.17545425316653 0.0987910651948236 no 392 0.119906514535012 125 786715 SGTC_1908 st060353 56.5 µM 1.17513049069876 0.0988530209182842 no 393 0.11997125688272 166 4227716 SGTC_2225 6654152 15.4 µM 1.17388809691199 0.0990910313275726 no 394 0.120219925391982 154 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_766 1391-0721 126 µM 1.17326299392924 0.0992109432127735 no 395 0.120345178693757 167 1020919 YIL115C NUP159 SGTC_1444 4112-3581 28 µM 1.17279196791229 0.0993013689893525 no 396 0.120439619954799 148 2877249 SGTC_1703 st026983 48.3 µM 1.17255769059191 0.0993463670875391 no 397 0.120486612260675 143 1104023 SGTC_3199 9111318 49.47 µM 1.17062856295026 0.0997174652372674 no 398 0.120874055546065 137 8548020 SGTC_2657 nystatin 74.44 µM 1.16969865588054 0.0998967088603025 no 399 0.121061129628252 135 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3255 9139072 49.47 µM 1.1667666975322 0.10046339702389 no 400 0.12165229965007 132 17646060 SGTC_1705 st027868 56.3335 µM 1.16672081236891 0.100472284299583 no 401 0.121661567559154 124 292948 SGTC_895 0964-0006 13.7 µM 1.16409863063204 0.100981115497835 no 402 0.122192021766304 184 6738897 SGTC_1984 st072354 53.1 µM 1.16386116465949 0.101027288079513 no 403 0.122240140001063 147 5762938 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.16188189301116 0.101412733939058 no 404 0.122641721552491 132 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_130 0136-0219 337.655 µM 1.15914327488264 0.101947820812648 no 405 0.123198894442039 165 234244 SGTC_2308 7584454 197.62 µM 1.15552310110368 0.102658300228938 no 406 0.123938139081238 156 893577 SGTC_2312 7706453 155.7 µM 1.15386269272514 0.102985365849459 no 407 0.124278233242533 155 976098 SGTC_1891 st059073 26.2 µM 1.15349903777141 0.103057099183083 no 408 0.12435280614384 170 688754 SGTC_2268 7933382 153.85 µM 1.15254761610831 0.103244945034347 no 409 0.12454805744181 146 935025 YOR257W CDC31 SGTC_1821 st053465 65.6 µM 1.1488273012775 0.103981859555565 no 410 0.125313599698901 132 675086 SGTC_1565 sinapyl alcohol 95.1 µM 1.14099109640669 0.10554650575688 no 411 0.126936814080963 164 5280507 A phenol propionate derived from cinnamic acid. SGTC_845 0330-0138 4.51 µM 1.13877720831552 0.105991619272497 no 412 0.127398045150807 172 9039800 SGTC_1399 3562-5772 25 µM 1.1366272619658 0.106425173676096 no 413 0.127847069224595 142 23847490 SGTC_652 0437-0092 114 µM 1.13453336901437 0.106848653912312 no 414 0.128285442362959 149 3091274 SGTC_1035 k081-0041 55.2 µM 1.13444458497444 0.106866636907423 no 415 0.128304053045588 164 731709 SGTC_1623 st003709 20.3 µM 1.13365208614795 0.107027252395932 no 416 0.128470257666534 156 16192618 SGTC_2073 5212005 126 µM 1.13125359262147 0.107514415063685 no 417 0.128974185434229 163 691789 SGTC_1931 st074438 57.1 µM 1.12663205942248 0.10845760565298 no 418 0.129949039271391 198 2787313 SGTC_189 3970-0742 2.116 µM 1.12588919735866 0.108609767119102 no 419 0.130106211209184 149 2891807 SGTC_2399 5884133 200 µM 1.12520614794838 0.108749812523468 no 420 0.130250844265706 158 722445 SGTC_1501 4491-0275 38.4 µM 1.12396024842087 0.109005593264472 no 421 0.130514945068535 157 5104718 SGTC_545 4218-0007 221 µM 1.12343142316349 0.109114290678387 no 422 0.130627155207616 165 2840508 SGTC_2891 9063876 19.48 µM 1.12284166302164 0.109235604804634 no 423 0.130752373623348 131 6472478 SGTC_182 3448-4371 550.524 µM 1.12112615355245 0.109589037302027 no 424 0.131117083775849 136 3491403 SGTC_898 1000-0849 28.3 µM 1.12067421278864 0.109682283489831 no 425 0.131213281334199 181 6751807 SGTC_465 cgp-37157 41 µM 1.11710989947484 0.110419683086113 no 426 0.131973669143825 130 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_872 0588-0139 234 µM 1.11618594340781 0.110611413666379 no 427 0.132171275056904 138 2047100 SGTC_1534 6-azauridine 81.6 µM 1.11405112188902 0.111055323836335 no 428 0.132628627894502 175 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2034 5197015 53.07 µM 1.1111047653028 0.111670076308862 no 429 0.133261628477427 163 780676 SGTC_788 1182-0090 188 µM 1.10955321282358 0.111994782007176 no 430 0.133595801057493 160 5715185 SGTC_160 3453-0671 289.699 µM 1.1092177217656 0.112065081558379 no 431 0.133668134654751 159 5322268 SGTC_2938 9059746 27.26 µM 1.10801198045152 0.112317995715959 no 432 0.133928320949264 164 6471769 SGTC_3017 9080681 49.47 µM 1.106690885535 0.112595574216928 no 433 0.134213798683997 154 16451914 SGTC_1756 st041558 35.5 µM 1.10359721487409 0.113247509173107 no 434 0.134883949945433 164 3955792 SGTC_1240 0356-0016 42.1 µM 1.09928196413391 0.114161361096484 no 435 0.1358225484014 148 4305613 SGTC_102 gallobenzophenone 83.616 µM 1.0952803364174 0.115013478764676 no 436 0.136696919713806 156 70837 SGTC_2246 7293507 91.5585 µM 1.09502235833392 0.115068568120953 no 437 0.136753420687079 172 887656 SGTC_1636 st007707 68.9 µM 1.09249408749771 0.115609455283717 no 438 0.137307993925449 176 403051 SGTC_739 1486-1183 203 µM 1.08935178953233 0.116284218942729 no 439 0.137999391323014 148 4346692 SGTC_704 1310-0270 142 µM 1.08641195804959 0.1169180316233 no 440 0.138648386695919 167 5718033 SGTC_2149 5554786 194.827 µM 1.08610328204676 0.116984722361287 no 441 0.138716650239233 156 745063 YPR165W RHO1 SGTC_1820 st053765 18.6 µM 1.08597850046713 0.117011689592207 no 442 0.138744252119723 163 3690829 SGTC_2921 7974240 10.71 µM 1.08543198269316 0.117129852440619 no 443 0.13886518677535 165 2979074 YDR527W RBA50 SGTC_122 0236-0016 402.397 µM 1.08522765037527 0.117174052926294 no 444 0.138910420310485 185 6808838 SGTC_2916 7875993 68.79 µM 1.08078510812637 0.118137971354348 no 445 0.139896357125462 168 1299250 SGTC_1442 4112-3290 3 µM 1.07851610016401 0.118632445985505 no 446 0.140401750346997 155 704353 SGTC_1693 xanthone 101.9 µM 1.078413450004 0.118654850594045 no 447 0.140424643663989 203 7020 An insecticide. SGTC_2115 tiliquinol 12.7705 µM 1.07676650976072 0.119014723559249 no 448 0.140792295300533 172 71208 A bioactive hydroxyquinoline. SGTC_9 0092-0002 10.449 µM 1.07490058859041 0.119423376454549 no 449 0.141209619222735 189 759368 SGTC_2944 9067346 25.62 µM 1.07065712340737 0.120356415410032 no 450 0.142161814195971 175 6473075 SGTC_2766 oltipraz 83.91 µM 1.06882720102784 0.120760353141648 no 451 0.142573770040242 181 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3274 9138298 49.47 µM 1.06590248851333 0.121407934910842 no 452 0.143233861981135 185 17015756 SGTC_520 3584-0023 682 µM 1.06437973994887 0.12174606251329 no 453 0.14357835400251 168 1340790 SGTC_177 1327-0068 8.361 µM 1.05758086583973 0.123263828795953 no 454 0.145123284823946 179 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2061 5245884 80.95 µM 1.05754377440313 0.123272145212072 no 455 0.145131743803615 176 573863 SGTC_838 0109-0203 71.4 µM 1.05523700382625 0.123790128005752 no 456 0.145658472164865 163 759422 SGTC_368 fentichlor 4.58 µM 1.0531494580886 0.124260195787389 no 457 0.146136249199843 176 7329 A pesticide. SGTC_1832 st054113 55 µM 1.05235928396746 0.124438450334367 no 458 0.14631737085156 150 1251267 SGTC_1467 k284-1082 293 µM 1.04973815878056 0.125031027171984 no 459 0.146919257270487 182 3334705 SGTC_2670 beta-carotene 100 µM 1.04776051428619 0.125479430289404 no 460 0.147374479476143 123 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3272 9137413 49.47 µM 1.04682449234618 0.125692050967222 no 461 0.147590265997725 181 17614870 SGTC_2505 galangin 7.89 µM 1.04052337123669 0.127129914165602 no 462 0.149048405847581 186 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1694 st024011 44.9 µM 1.03912531837526 0.127450483477095 no 463 0.149373228670571 181 2787533 SGTC_2794 7785382 27.27 µM 1.03856654579096 0.12757876545229 no 464 0.149503185666731 177 2205081 SGTC_96 0929-0093 37.281 µM 1.03818029844953 0.127667491858756 no 465 0.149593061557802 197 6991579 SGTC_32 0928-0142 34.1 µM 1.03813528174208 0.127677835615234 no 466 0.149603538840553 175 2244242 SGTC_2098 5376439 882.5 nM 1.03670393243994 0.128007029029848 no 467 0.149936929381697 169 2844116 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.02930301311397 0.129718557355289 no 468 0.151668653925762 171 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1688 st021091 57.6 µM 1.02913929246351 0.129756597538376 no 469 0.151707112243584 185 3656366 SGTC_2870 9038528 12.99 µM 1.02723424729437 0.130199799129459 no 470 0.152155087704727 176 6463316 SGTC_3186 9110464 49.47 µM 1.0262059522235 0.130439462913413 no 471 0.152397258156963 158 17018021 SGTC_2738 aclarubicin 5.55 µM 1.02134805151159 0.131575814012143 no 472 0.15354478405483 138 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2214 7179297 48.276 µM 1.02047148047969 0.131781585370321 no 473 0.153752454169695 160 769744 SGTC_892 0929-0076 29 µM 1.01861622489395 0.132217830757684 no 474 0.154192599243736 176 5751038 SGTC_2233 sulbentine 40.3845 µM 1.01417227179408 0.133266828429287 no 475 0.155250278554003 203 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3150 9097574 49.47 µM 1.01084526180366 0.134055909864815 no 476 0.156045248059322 163 17217476 SGTC_717 1532-0246 73.2 µM 1.0085006136019 0.134613924834417 no 477 0.156607096648735 168 9561992 SGTC_1210 3013-0140 750 nM 1.00642071869841 0.135110262402981 no 478 0.157106615639455 181 905973 SGTC_2071 5230951 39.92 µM 1.00487342660725 0.135480314887014 no 479 0.157478900790111 190 1799272 SGTC_2456 5770359 74.46 µM 1.00406548852115 0.135673818219158 no 480 0.157673524392856 202 3118787 SGTC_2020 4017018 200 µM 1.00143685059952 0.136304693594467 no 481 0.158307827929856 174 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2989 9073649 71.4286 µM 0.999953132257397 0.136661672109103 no 482 0.158666594818846 194 21367202 SGTC_2575 plumbagin 510 nM 0.99985907014193 0.136684324720932 no 483 0.158689357234238 181 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2692 st077426 47.7 µM 0.997974988134476 0.137138601584543 no 484 0.159145743640794 187 25238571 SGTC_3183 9108214 49.47 µM 0.996132136712069 0.137583933979102 no 485 0.159592973594412 136 4974831 SGTC_2608 thymoquinone 42.66 µM 0.994957936526605 0.137868198433072 no 486 0.159878361408906 182 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3187 9109394 49.47 µM 0.993274853341073 0.138276357740716 no 487 0.160288014376991 204 17098090 SGTC_2403 6032726 181.2 µM 0.991829453246266 0.138627534093329 no 488 0.160640363679926 169 2881040 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.98867658347888 0.139395666279492 no 489 0.161410701613171 192 390807 SGTC_2250 alverine citrate 130 µM 0.985735470256528 0.14011481393473 no 490 0.162131469406614 187 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2513 baicalein 25.65 µM 0.98511703070759 0.140266352120271 no 491 0.162283294395358 190 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1621 st003705 32.4 µM 0.985082176829132 0.140274895787788 no 492 0.162291853668499 181 24207032 SGTC_1995 st072814 61.1 µM 0.984899764778967 0.140319615885494 no 493 0.16233665446868 175 5769371 SGTC_1979 st071809 45.3 µM 0.983719543047542 0.1406091927485 no 494 0.162626714041496 185 4976333 SGTC_2747 doxorubicin 7.63 µM 0.981446848486575 0.141167958464026 no 495 0.163186216559858 129 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2446 5162541 200 µM 0.98059704952914 0.141377276622995 no 496 0.163395744947969 185 1549321 SGTC_1489 4065-0444 182 µM 0.98032176909714 0.141445127384691 no 497 0.16346365618202 185 2877968 SGTC_1655 st012546 55.1 µM 0.979648537577248 0.141611157577109 no 498 0.163629818527935 173 720985 YLR208W SEC13 SGTC_2630 antimycin a 100 µM 0.97941423185559 0.141668972259921 no 499 0.163687673960981 194 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2808 7946468 45.46 µM 0.979319568885565 0.141692334779345 no 500 0.163711052175931 204 2970879 SGTC_1955 wogonin 32.4 µM 0.978413675810993 0.141916038285112 no 501 0.163934883513964 153 5281703 A flavanone. SGTC_1096 rimcazole 32.2 µM 0.976987875991023 0.142268613011532 no 502 0.164287577318715 177 18528119 A dopamine reuptake inhibitor. SGTC_3352 9151559 45.5865 µM 0.975597824784365 0.142612917869572 no 503 0.164631901452439 173 17159339 SGTC_1472 k841-0093 193 µM 0.975572101679276 0.142619294587624 no 504 0.164638277625446 190 X1472 SGTC_204 PMA1.184 62.41 µM 0.973016734843538 0.143253727094656 no 505 0.165272492435533 198 2252213 YGL008C PMA1 SGTC_334 1502-1024 68.5 µM 0.972615395601423 0.143353542330959 no 506 0.165372244023791 170 3296216 SGTC_2184 6075246 200 µM 0.971202691436709 0.143705263010798 no 507 0.165723676946581 194 2267320 SGTC_2063 5246145 200 µM 0.970356316106533 0.143916263632957 no 508 0.165934457583351 201 711240 SGTC_2055 5235184 200 µM 0.969248233414727 0.144192823417193 no 509 0.166210675396844 191 2836034 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.965116408208992 0.145227218507595 no 510 0.167243254697908 222 2346 DNA damaging agent; causes G2/M arrest. SGTC_2325 6158266 200 µM 0.965069182226037 0.145239070236585 no 511 0.167255080735103 173 3623240 SGTC_2676 harmalol 100 µM 0.963475130975866 0.14563949155651 no 512 0.167654569273181 192 5459187 A monoamine oxidase inhibitor SGTC_1633 st005664 67.9 µM 0.958108913180458 0.146992921755578 no 513 0.169003920708762 181 2063822 SGTC_3324 9138759 60.749 µM 0.957910637605068 0.147043090505477 no 514 0.169053910957429 179 45595710 SGTC_1141 3253-0389 52.6 µM 0.957572624881695 0.147128642766176 no 515 0.1691391543399 207 5402031 SGTC_3350 9150499 3.57 µM 0.956364469420357 0.147434704115285 no 516 0.169444064484378 205 4910996 YPR165W RHO1 SGTC_661 1304-0007 33.6 µM 0.956340553151138 0.147440767113386 no 517 0.169450103948893 197 3117130 SGTC_1360 1598-0022 39.8 µM 0.956170390431827 0.147483909778259 no 518 0.1694930783388 201 761525 SGTC_762 1165-0429 115 µM 0.955666923155061 0.14761160724403 no 519 0.169620269345352 201 5967793 SGTC_1014 4130-3005 69.3 µM 0.950878300220394 0.148829876345652 no 520 0.170833079278387 190 743608 SGTC_170 4197-0004 226 µM 0.948844600301344 0.149349295103853 no 521 0.171349827158342 217 218692 SGTC_205 1486-1330 71.903 µM 0.94841851802359 0.149458272144389 no 522 0.171458217936864 195 4118834 SGTC_1521 st012942 49.4 µM 0.947047210900649 0.149809365071383 no 523 0.171807361200648 184 24207259 SGTC_987 1497-1013 404 µM 0.944715779283344 0.15040753846114 no 524 0.172401999504174 193 1676435 SGTC_3013 9080133 71.4286 µM 0.941430232800754 0.151253206161468 no 525 0.173242213270948 203 17050193 SGTC_1573 oleylamine 1.06 µM 0.940233571575369 0.15156199935592 no 526 0.173548882510636 205 5356789 An amine of the fatty acid oleic acid. SGTC_844 0330-0132 15.3 µM 0.938359828121419 0.152046351958432 no 527 0.174029761597698 202 2828079 SGTC_1436 4092-1007 8.32 µM 0.935406010946596 0.15281198330806 no 528 0.174789550162491 173 2881121 SGTC_176 1486-1328 72.834 µM 0.933182928986478 0.153389890989136 no 529 0.1753627636035 191 22310231 SGTC_2580 diallyl disulphide 81.36 µM 0.932975935657676 0.153443774119071 no 530 0.175416196650797 203 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_391 gliotoxin 8.33 µM 0.932238489857643 0.153635843004838 no 531 0.17560664403371 196 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_466 geldanamycin 89.2 µM 0.931359517305737 0.153864980604571 no 532 0.175833812172249 169 5288382 HSP90 inhibitor. SGTC_2969 9091408 28.7 µM 0.930415535178587 0.154111317181296 no 533 0.176077989057315 178 4286311 SGTC_68 0986-0284 82.829 µM 0.928403200713713 0.154637315733363 no 534 0.176599229433315 190 423278 YIL048W NEO1 SGTC_518 1021-0119 62.6 µM 0.92652721641938 0.155128741397331 no 535 0.177086029913432 214 1097762 SGTC_441 propafenone 146 µM 0.926158833151563 0.155225362647954 no 536 0.17718172143025 224 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1994 st072947 40.9 µM 0.925453793385487 0.155410394450272 no 537 0.177364954144218 197 5286565 YDL195W SEC31 SGTC_2277 7947813 106.88 µM 0.925095994827737 0.15550435134307 no 538 0.177457988123159 193 1246798 SGTC_2991 9074669 71.4286 µM 0.922348610456854 0.156227055158868 no 539 0.178173382934955 227 17333109 SGTC_2644 guaiazulene 100 µM 0.92030166849414 0.156766942660991 no 540 0.178707568707429 189 3515 A coloring agent. SGTC_349 k015-0014 24 µM 0.920140253028615 0.156809568675165 no 541 0.178749735783584 196 2196908 SGTC_2046 4110841 106 µM 0.919902041954425 0.156872488528732 no 542 0.178811975863104 213 44119630 YMR134W ERG29 SGTC_313 3474-0040 5.03 µM 0.918889873322319 0.157140022791469 no 543 0.179076588620712 221 1043375 YIL048W NEO1 SGTC_2242 6630449 61.2675 µM 0.918357014265138 0.157280987455484 no 544 0.179215993695943 186 691249 YDR170C SEC7 SGTC_2 0422-0095 29 µM 0.917657030164785 0.157466290345925 no 545 0.179399225243121 192 6790840 SGTC_897 1000-0139 31.4 µM 0.917438695868577 0.157524118111894 no 546 0.179456401674983 203 6151020 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.917047224692627 0.157627837647375 no 547 0.179558947116249 198 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2515 chrysin 20.77 µM 0.916481431995317 0.157777822603507 no 548 0.179707220951112 184 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2449 5812982 45.77 µM 0.91527027704691 0.158099200448722 no 549 0.180024879434051 187 776185 SGTC_2669 eugenol 100 µM 0.914569243439903 0.158285414683682 no 550 0.18020890564661 179 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3049 9092223 49.47 µM 0.911522507110895 0.159096384705669 no 551 0.181010066111655 186 8623917 SGTC_556 4058-0063 51.5 µM 0.906679730837314 0.160391010513931 no 552 0.182288092548029 199 6615692 SGTC_487 nimodipine 119 µM 0.904497597386746 0.160976606637944 no 553 0.182865803893186 185 4497 L-type voltage-gated calcium channels inhibitor SGTC_2920 7982904 15.77 µM 0.904403048178094 0.161002011313845 no 554 0.18289086123069 208 6456808 SGTC_763 3453-1109 128 µM 0.900900180208362 0.161945050227214 no 555 0.183820697704113 213 1560353 SGTC_3208 9114115 49.47 µM 0.900266270678166 0.162116094515658 no 556 0.183989283136437 216 650895 SGTC_2269 7935389 174.42 µM 0.896947001443518 0.163013634532135 no 557 0.184873599046279 218 97605 SGTC_493 zm226600 134 µM 0.89622452438245 0.163209421678448 no 558 0.185066430038539 216 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2679 rapamycin 1 nM 0.894712195664561 0.163619748581524 no 559 0.185470478811221 210 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1361 1608-0041 5.61 µM 0.893093573995982 0.164059656433398 no 560 0.18590353197706 233 X1361 SGTC_992 3909-8734 162 µM 0.890997355229593 0.164630504433787 no 561 0.186465294546995 194 4288319 SGTC_754 3474-0146 171 µM 0.888069307858245 0.165430030070894 no 562 0.187251735521959 210 24762078 SGTC_3200 9114385 49.47 µM 0.886358473834935 0.165898347025112 no 563 0.187712194357222 196 17018030 YLR208W SEC13 SGTC_511 blebbistatin 171 µM 0.885977324490136 0.16600279794425 no 564 0.187814873188336 209 3476986 A myosin inhibitor. SGTC_1740 st038286 13.222 µM 0.883746535134587 0.166614979847503 no 565 0.18841652679609 218 716786 SGTC_3090 9117696 49.47 µM 0.883574205875442 0.16666233166417 no 566 0.188463054158831 196 7923821 SGTC_2374 9071832 200 µM 0.883544403537764 0.166670521489925 no 567 0.188471101242755 205 17381698 SGTC_8 0354-0001 70 µM 0.882557337023868 0.166941918858299 no 568 0.188737743917496 212 4993152 SGTC_3232 9132874 49.47 µM 0.881742165507109 0.167166267875433 no 569 0.188958126690087 205 3784940 SGTC_1350 1495-0454 146 µM 0.877684740353017 0.168285829847891 no 570 0.190057413929914 209 1069057 SGTC_111 0083-0039 52.457 µM 0.877383630000401 0.168369106784815 no 571 0.190139150797883 180 759313 SGTC_1837 st055472 66.5 µM 0.875736439238345 0.168825132968476 no 572 0.190586665432792 206 676091 SGTC_131 0141-0277 33.849 µM 0.874936012917602 0.169047017938517 no 573 0.190804361345432 221 1547771 SGTC_576 1073-0113 22.7 µM 0.874744695425378 0.169100080491887 no 574 0.190856417496007 245 5439563 SGTC_321 4534-3890 65.3 µM 0.874287725902158 0.169226865813963 no 575 0.190980790962198 218 699746 SGTC_1430 4049-0248 69.1 µM 0.87345908338187 0.169456926727069 no 576 0.191206449495142 235 22774488 SGTC_1329 1447-1697 50.6 µM 0.871923709841638 0.169883731736075 no 577 0.191624999046672 202 2840515 SGTC_406 estrone 100 µM 0.87029869853755 0.170336204438884 no 578 0.192068594997001 211 5870 A steroid. SGTC_2964 9083345 53.42 µM 0.868132425744387 0.170940586812238 no 579 0.19266092086443 237 17741579 SGTC_2708 st078559 56 µM 0.867063492763564 0.171239320197126 no 580 0.192953611020391 199 17250902 SGTC_2025 5147754 141 µM 0.866247126355709 0.171467693786715 no 581 0.193177327387331 208 315777 YLR208W SEC13 SGTC_1299 1079-1439 3.74 µM 0.865897754641907 0.171565487869324 no 582 0.193273117279277 215 323161 SGTC_3234 9132280 49.47 µM 0.864380246807534 0.171990673246331 no 583 0.19368952021334 218 17612295 SGTC_1179 1021-1431 9.29 µM 0.864347192223287 0.171999942178111 no 584 0.193698596447895 246 2840958 SGTC_675 1309-0189 238 µM 0.86203208237141 0.172649922080498 no 585 0.194334931764971 206 4246530 SGTC_1641 st009299 47.1 µM 0.861900011278846 0.172687048926134 no 586 0.194371271402602 215 4046054 SGTC_1054 3429-0080 167 µM 0.861271203911211 0.172863884384655 no 587 0.194544345799334 224 1162877 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.861059280919031 0.172923508117793 no 588 0.194602697099646 226 756377 SGTC_2118 5526350 200 µM 0.860945780897969 0.172955446307671 no 589 0.194633952801224 218 743594 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.860837249731195 0.172985989808311 no 590 0.194663843033557 202 5379071 SGTC_2635 hydroquinidine 100 µM 0.86076136569519 0.173007347596238 no 591 0.194684743679725 195 442912 An experimental heart treatment. SGTC_461 N-acetylfarnesylcysteine 136 µM 0.860644669353425 0.173040195407222 no 592 0.194716887872842 240 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1059 3448-6867 171 µM 0.85860541499882 0.173614848133246 no 593 0.195279124790409 239 3934407 SGTC_218 alverine citrate 93.75 µM 0.855822346350054 0.174401061375914 no 594 0.196048026381239 222 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3301 9125354 19.7965 µM 0.855164035591904 0.174587363565278 no 595 0.19623017159718 193 41905162 SGTC_1665 st014639 11.4 µM 0.85498731932332 0.174637395842988 no 596 0.196279083936545 226 981133 YIL048W NEO1 SGTC_1877 wortmannin 25 µM 0.853248214827258 0.17513026029356 no 597 0.196760835452946 216 312145 A covalent inhibitor of PI 3-kinase. SGTC_277 nystatin 15.5 µM 0.852376414893829 0.175377661193399 no 598 0.197002603068721 234 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1224 0823-0416 294 µM 0.850090879021599 0.176027305793263 no 599 0.197637281103978 213 3598164 SGTC_472 calcifediol 10 µM 0.849688039259654 0.176141967392218 no 600 0.197749274990858 207 5283731 A vitamin D metabolite. SGTC_1079 idarubicin 2.36 µM 0.84929602237387 0.176253593818424 no 601 0.197858296808565 246 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2065 5221596 34.26 µM 0.849009181958067 0.176335299703267 no 602 0.197938091534686 213 788581 SGTC_2564 betulinic acid 100 µM 0.848510558770171 0.176477388491271 no 603 0.198076847324639 223 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_811 0416-0114 265 µM 0.848493353819371 0.176482292545072 no 604 0.198081636129444 219 6612453 SGTC_1424 4048-1941 275 µM 0.847943549773411 0.176639052629498 no 605 0.198234704720264 226 X1424 SGTC_58 0957-0393 9 µM 0.847470516582192 0.176773994255519 no 606 0.198366456989999 240 6997992 SGTC_1784 st039334 36.3 µM 0.847122406825812 0.176873340732474 no 607 0.198463448518565 254 3496984 SGTC_1248 0469-0687 58.6 µM 0.844721814923802 0.17755940217833 no 608 0.199133088282106 215 4017482 SGTC_2561 acetosyringone 100 µM 0.844230316569515 0.177700073591344 no 609 0.199270358330572 257 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_497 capsazepine 133 µM 0.841631137618217 0.17844515151933 no 610 0.199997227256013 225 2733484 A calcium channel blocker. SGTC_2973 9094665 17.96 µM 0.840613452608469 0.178737415398605 no 611 0.20028225993165 242 25237061 YIL048W NEO1 SGTC_904 1141-0088 396 µM 0.83990099278014 0.178942202417706 no 612 0.200481950475934 220 1378119 SGTC_476 mead acid 10 µM 0.838319701498243 0.179397250676204 no 613 0.200925586920243 219 5312531 An omega 9 fatty acid. SGTC_51 1013-0126 23.419 µM 0.837987060742565 0.179493067259674 no 614 0.20101898530172 202 1627850 SGTC_136 0097-0015 404.482 µM 0.837114843367156 0.179744460661958 no 615 0.201264008853407 222 4861337 SGTC_3045 9092950 49.47 µM 0.836944247418689 0.179793656246909 no 616 0.201311953642542 233 44120432 SGTC_2007 4011539 71.82 µM 0.83651185433071 0.179918385432762 no 617 0.201433505337997 205 45595301 SGTC_3078 9116413 49.47 µM 0.83639949599898 0.179950805489735 no 618 0.201465098021939 249 17177322 SGTC_3262 9137218 49.47 µM 0.836203654873351 0.180007322577996 no 619 0.201520171323348 189 17650664 SGTC_2207 7258803 200 µM 0.835713580423811 0.180148800241998 no 620 0.201658026732481 235 3666799 SGTC_193 1273-0060 1.558 µM 0.835154839975958 0.180310185952071 no 621 0.201815266426295 225 2847393 YHR072W ERG7 SGTC_3305 9127027 53.8275 µM 0.83515193613897 0.180311024928673 no 622 0.201816083810393 227 41905295 SGTC_1457 k015-0032 57.3 µM 0.83236810619288 0.181116455726782 no 623 0.202600599380319 228 4302660 SGTC_1591 genipin 88.4 µM 0.822208298010798 0.18407502005736 no 624 0.205479178430495 237 442424 A DNA cross-linking agent. SGTC_953 1188-0045 9.7 µM 0.822063498266444 0.184117402437382 no 625 0.205520379304236 225 6144426 SGTC_2193 5925765 200 µM 0.821235718648625 0.184359807248874 no 626 0.205756007324186 215 877370 SGTC_1921 5740136 50 µM 0.819380419854634 0.1849038289037 no 627 0.206284701312584 209 1774243 SGTC_1618 st003135 44.5 µM 0.819060724650774 0.18499767248062 no 628 0.206375884300744 249 1270615 SGTC_2642 cholecalciferol 100 µM 0.818920964883017 0.185038706965179 no 629 0.206415753874429 225 9821465 A vitamin D precursor, similar to steriods. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.818835539456957 0.185063791275976 no 630 0.206440125619107 234 5024745 SGTC_338 4055-0136 114 µM 0.815378552903954 0.18608067227909 no 631 0.207427828464736 216 2900563 SGTC_37 0566-0070 1.56 µM 0.813458165111267 0.186647052546819 no 632 0.207977711286008 229 1626686 SGTC_569 4130-2812 160 µM 0.813238028967283 0.186712045451686 no 633 0.208040799886403 234 743552 SGTC_1453 4237-0541 195 µM 0.81150310567927 0.187224753661808 no 634 0.208538405056692 225 739892 SGTC_2892 9047358 58.44 µM 0.809924188789431 0.187692114430269 no 635 0.208991874324456 224 6466771 SGTC_3190 9110366 49.47 µM 0.809687576558264 0.187762213896884 no 636 0.209059880011042 207 17123768 SGTC_2276 7947513 42.08 µM 0.809635158142306 0.187777745725591 no 637 0.209074947564903 233 2105100 SGTC_2909 7941780 10.49 µM 0.80961221203927 0.187784545015965 no 638 0.209081543571012 225 1243215 SGTC_1196 1588-0294 184 µM 0.80861749482318 0.188079441491279 no 639 0.20936759926365 228 6144269 SGTC_1435 4092-0789 56.7 µM 0.808165950988534 0.188213401637422 no 640 0.209497527897569 242 2248285 SGTC_202 3594-0513 34.79 µM 0.807880894759876 0.188297999978301 no 641 0.209579575286491 234 708429 SGTC_2275 7947463 200 µM 0.807053316358797 0.188543739707791 no 642 0.209817883235537 242 1225414 SGTC_1959 st077091 55.8 µM 0.806782506421664 0.188624196475412 no 643 0.20989589974341 253 821356 YKL052C ASK1 SGTC_1150 3909-7983 10.9 µM 0.805753130503463 0.188930213867431 no 644 0.210192603903005 248 23965914 SGTC_167 3672-0051 66.205 µM 0.805542823905706 0.188992772345039 no 645 0.210253252323364 224 3237971 SGTC_230 MPP+ 141.667 µM 0.804978779517618 0.189160617799638 no 646 0.210415962723352 237 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1680 diphenhydramine 100 µM 0.804921753846314 0.189177592316088 no 647 0.21043241708423 231 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1872 amphotericin b 148 nM 0.80460892594295 0.189270726754122 no 648 0.210522694836022 228 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1028 k015-0029 4.8 µM 0.804232332189207 0.189382882859377 no 649 0.210631404665829 244 4588309 SGTC_1037 k284-1091 78.7 µM 0.802820279625841 0.18980378054918 no 650 0.211039309467832 230 3334711 SGTC_1466 k213-0079 57.5 µM 0.802783515380042 0.189814746732648 no 651 0.211049935871487 270 3657981 SGTC_2203 7227154 166.4 µM 0.800358424905349 0.190538972480561 no 652 0.211751580803303 223 896304 SGTC_1115 galangin 695.678 nM 0.800032328044652 0.190636486842985 no 653 0.211846033543047 253 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_358 0075-0058 9.45 µM 0.79999548019714 0.190647507563652 no 654 0.211856707934473 268 1069125 SGTC_779 1360-0071 233 µM 0.798753679083767 0.191019143049969 no 655 0.212216627184144 242 7566 SGTC_1859 st055998 20 µM 0.795914410780636 0.191870522447834 no 656 0.213040892293696 245 676301 SGTC_274 sirtinol 40.1 µM 0.795729573848306 0.191926027834391 no 657 0.213094616793601 225 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_764 1951-2361 146 µM 0.795093132998901 0.192117222253508 no 658 0.213279664438641 239 5438930 SGTC_19 0279-0214 38.434 µM 0.794646067258468 0.192251595787348 no 659 0.21340970654294 253 3566274 YBR002C RER2 SGTC_1249 0481-0015 10.2 µM 0.793092370662652 0.192719033727371 no 660 0.213862003763923 263 4227577 SGTC_532 1548-0774 215 µM 0.793074877594311 0.192724300561013 no 661 0.2138670993534 258 5932993 SGTC_2406 ethylparaben 405.7 µM 0.79307285964213 0.192724908134093 no 662 0.213867687171114 216 8434 A possible steroid mimic. SGTC_1449 4112-4002 201 µM 0.792515773312839 0.19289268266196 no 663 0.214029999147839 229 2059539 SGTC_2780 5215298 71.43 µM 0.789047282920738 0.193939273761089 no 664 0.215042185827759 256 2834131 SGTC_1814 st052110 31.539 µM 0.787939994987954 0.194274116994165 no 665 0.215365902718209 242 674163 SGTC_2346 9031566 143.75 µM 0.787109138024512 0.194525598699176 no 666 0.215608990261438 235 4771086 SGTC_1145 3546-0597 10.2 µM 0.786516099294629 0.194705219295635 no 667 0.215782595524928 251 875334 SGTC_3317 9138495 8.753 µM 0.78575694844203 0.194935299420504 no 668 0.216004946399435 255 17020139 SGTC_2998 9066762 71.4286 µM 0.78167850164665 0.196174204793791 no 669 0.217201769573818 228 4945196 SGTC_988 1497-1057 103 µM 0.781358231533751 0.196271694676936 no 670 0.217295915005198 248 3533044 SGTC_2331 7980721 200 µM 0.780697510226257 0.196472910324744 no 671 0.217490212666649 242 2981221 SGTC_456 gingerol 170 µM 0.780038222520526 0.196673813935571 no 672 0.21768418867338 271 442793 A herb. SGTC_1882 5615643 20 µM 0.77768541195273 0.197391795693072 no 673 0.218377247158471 231 2253075 SGTC_2329 6138490 200 µM 0.776159121814415 0.197858403685585 no 674 0.218827519520063 242 720019 SGTC_1815 st051655 58.2 µM 0.77483942575884 0.198262389690563 no 675 0.21921727462436 250 5984156 SGTC_3266 9136860 49.47 µM 0.774431679095842 0.198387309907181 no 676 0.21933777795612 244 4871271 YPR165W RHO1 SGTC_1275 0867-0008 21.1 µM 0.77417130447922 0.198467104999836 no 677 0.219414747629552 233 3422836 SGTC_2210 7115885 190.385 µM 0.770898406894846 0.199471776399789 no 678 0.220383575750283 254 2927039 SGTC_2594 a-mangostin 100 µM 0.769768375459011 0.19981936845374 no 679 0.220718651092615 254 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3106 9121286 49.47 µM 0.768810421431503 0.200114315487696 no 680 0.221002930661301 223 15943471 SGTC_112 phenothiazine 287.218 µM 0.768464539993107 0.200220874119225 no 681 0.221105624870435 244 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.767975157107293 0.200371700699762 no 682 0.221250972130397 220 6312947 SGTC_1016 4226-1401 38 µM 0.766722379220336 0.200758114588521 no 683 0.221623297472683 251 2901613 SGTC_2863 9028737 58.44 µM 0.764463095519117 0.201456110451617 no 684 0.222295660460197 256 6460917 SGTC_2173 5763948 167 µM 0.763645857857343 0.201708950209778 no 685 0.222539156768585 254 2867177 SGTC_611 3453-1652 23.7 µM 0.763500728640605 0.201753870643042 no 686 0.222582413976429 268 1560575 SGTC_485 niflumic acid 177 µM 0.76300132548109 0.201908491810805 no 687 0.222731302684588 246 4488 A COX2 inhibitor. SGTC_3250 9135583 49.47 µM 0.762821295169377 0.20196424873157 no 688 0.222784989629886 236 7699353 SGTC_311 1315-0136 58 µM 0.762771724359857 0.201979602851535 no 689 0.222799773464852 239 6759207 SGTC_2767 sibutramine 71.45 µM 0.762402848450107 0.202093880845733 no 690 0.222909803357396 243 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_571 k831-0106 44.2 µM 0.762226740537744 0.202148452832848 no 691 0.222962344497769 260 4783639 SGTC_3246 9135460 32.98 µM 0.760984090570046 0.202533773401923 no 692 0.223333284928003 253 41446951 SGTC_36 0335-0881 14.2 µM 0.760751522532489 0.202605936782673 no 693 0.223402747242857 243 23828853 SGTC_1874 staurosporine 7.6 µM 0.76043658073167 0.202703684356744 no 694 0.223496832152801 258 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1811 st050069 61.5 µM 0.760312612210692 0.202742167835504 no 695 0.223533872373692 264 3877702 SGTC_1684 st024538 14.6195 µM 0.758949779343135 0.203165519006523 no 696 0.223941299652739 246 6732859 SGTC_1429 4049-0205 9.46 µM 0.756869290375847 0.203812820019713 no 697 0.224564087660256 233 22774478 SGTC_3151 9099821 49.47 µM 0.75581619181659 0.204140937875552 no 698 0.224879703691039 263 17174189 SGTC_2531 methyl deoxycholate 70.07 µM 0.755524594548099 0.204231847517313 no 699 0.224967140489274 265 16667744 Haematoxylin. SGTC_1778 st046819 58.9 µM 0.755449506439927 0.204255261217594 no 700 0.224989659127335 268 671715 SGTC_3225 9130819 49.47 µM 0.754294885040247 0.204615492268019 no 701 0.225336086503369 274 4547121 SGTC_516 3992-2719 87.3 µM 0.753870833573897 0.204747887196249 no 702 0.225463392780613 237 5350887 YDR037W KRS1 SGTC_1846 st056244 14.8 µM 0.75365050027135 0.204816698512936 no 703 0.225529556039414 254 5393182 SGTC_1930 st074634 34.3 µM 0.753368991003963 0.204904635431962 no 704 0.225614105641195 254 684253 YOR116C RPO31 SGTC_262 fenpropimorph 62.5 µM 0.75315111143417 0.204972711328173 no 705 0.225679556760347 272 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1383 3049-0032 20.7 µM 0.752701650752082 0.205113186601136 no 706 0.225814608879973 264 712864 SGTC_2056 5235370 200 µM 0.750964116648988 0.205656776587294 no 707 0.22633712575213 247 5511916 SGTC_3031 9088762 49.47 µM 0.750614253511056 0.205766335093881 no 708 0.226442420264958 252 205253 SGTC_40 0327-0103 19.753 µM 0.750027555912192 0.205950135260227 no 709 0.226619054345979 238 409036 SGTC_353 1988-1175 58.3 µM 0.749148457180935 0.20622572083035 no 710 0.226883865667075 264 2788357 SGTC_2684 capsaicin 100 µM 0.748655884432015 0.206380231238546 no 711 0.227032319852485 262 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_289 k017-0060 526 µM 0.747055715173457 0.206882646112056 no 712 0.227514965125948 249 5512909 SGTC_427 1354-0053 47.3 µM 0.747052376136872 0.206883695245975 no 713 0.227515972854572 253 6813657 SGTC_1302 1159-0335 255 µM 0.7436498654876 0.207954408565844 no 714 0.228544163591035 244 649284 SGTC_2499 avocadenofuran 51.48 µM 0.743364394083105 0.208044390172752 no 715 0.228630547541837 255 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_726 3448-4391 34.2 µM 0.74273832145536 0.208241810957097 no 716 0.228820061974318 259 1356692 SGTC_2829 7992743 58.44 µM 0.742422247958659 0.208341521043786 no 717 0.228915772042286 243 16462845 SGTC_1175 0741-0056 27.6 µM 0.742030755935349 0.208465062062907 no 718 0.229034350699504 261 765927 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.741658039944679 0.208582718163474 no 719 0.229147274314801 259 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_148 3253-0744 288.01 µM 0.741105375619797 0.208757251006376 no 720 0.229314775236264 259 6893655 SGTC_2282 7944268 200 µM 0.740955769993611 0.208804511653215 no 721 0.22936012935459 262 2970414 SGTC_3284 9108171 64.8615 µM 0.740863608469965 0.20883362875783 no 722 0.229388071345622 243 8687505 SGTC_3201 9113999 49.47 µM 0.740759014471555 0.208866676621624 no 723 0.229419784987783 236 16649224 SGTC_2841 9004761 38.96 µM 0.74030562295585 0.209009967318585 no 724 0.229557284920901 229 2991039 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.738812387719107 0.209482301320685 no 725 0.230010464291373 246 6708739 YPR165W RHO1 SGTC_236 1509-0011 5.31 µM 0.738226324403506 0.209667853912799 no 726 0.230188464348546 292 3107280 SGTC_1075 aripiprazole 15.2 µM 0.7370186828106 0.210050508067452 no 727 0.23055549398572 251 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1515 3460-0031 42.1 µM 0.736438621328755 0.210234452530853 no 728 0.230731904016907 261 2876596 SGTC_1920 st075728 45.7 µM 0.735857207144546 0.21041892085051 no 729 0.230908801074701 241 3400306 SGTC_1188 1403-0014 4.57 µM 0.735696840859458 0.210469817813823 no 730 0.230957606331698 249 9614867 SGTC_1087 pterostilbene 9.05 µM 0.733878547941438 0.211047411892529 no 731 0.231511381243763 276 5281727 Similar to reservatol, lowers cholesterol. SGTC_857 0438-0306 1.35 µM 0.731905984149658 0.211675060744106 no 732 0.232112976716784 253 4686136 SGTC_413 propylparaben 100 µM 0.731050381612624 0.211947643746069 no 733 0.232374189994338 255 7175 A pharmaceutical preservative. SGTC_1332 1480-0653 17.5 µM 0.72984293061569 0.212332669867212 no 734 0.232743099762053 248 5749438 SGTC_1255 0566-0045 221 µM 0.726872084558721 0.213281737103622 no 735 0.233652159693879 251 2788469 SGTC_1088 bifonazole 369 nM 0.726607581698208 0.213366355000236 no 736 0.233733191207732 250 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2380 9035439 200 µM 0.723965938719516 0.214212524025391 no 737 0.234543323233938 259 6462575 SGTC_31 0508-1974 57.237 µM 0.723801898764504 0.214265133479774 no 738 0.234593681739248 232 6810525 SGTC_732 3970-1727 52.7 µM 0.722113054703756 0.214807201587211 no 739 0.235112486298073 272 1275699 SGTC_1117 retinoic acid 1.10837 µM 0.72195330010244 0.214858519220326 no 740 0.235161594909638 263 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2094 5332512 191.667 µM 0.721276774866329 0.215075916915615 no 741 0.235369621742878 262 755774 SGTC_3251 9135047 49.47 µM 0.720173205633513 0.21543081681435 no 742 0.235709179531597 240 17682963 SGTC_1264 0783-0040 158 µM 0.715278342104293 0.217009059219302 no 743 0.237218534272311 262 2855798 SGTC_1746 st038117 42 µM 0.714657040211942 0.217209861310686 no 744 0.237410494684085 258 2898218 SGTC_1365 1672-3266 55.4 µM 0.71390684899595 0.217452462851586 no 745 0.237642390971754 267 6415873 SGTC_2894 9048625 32.47 µM 0.713124714595191 0.217705560858877 no 746 0.237884293691932 281 4092861 SGTC_2019 4016004 108 µM 0.712904821886476 0.217776748543794 no 747 0.237952327596375 271 45595336 SGTC_738 1315-0003 72.4 µM 0.710815465927547 0.218453822636518 no 748 0.238599297701901 284 6251474 SGTC_835 0312-0010 67.2 µM 0.709863357002553 0.218762763518534 no 749 0.238894437711807 276 1626196 SGTC_1023 4482-3888 16 µM 0.709738713553589 0.21880322650448 no 750 0.238933090154168 270 3303168 SGTC_711 k292-0785 179 µM 0.708710026268338 0.219137333512332 no 751 0.23925222081994 270 4146315 SGTC_1560 lithocholic acid 53.1 µM 0.70799973455561 0.219368200016938 no 752 0.23947271116044 258 9903 A bile acid which acts as a detergent. SGTC_2581 avocatin a 64 µM 0.706703644303615 0.219789828935717 no 753 0.239875332187064 273 6710728 A skin care supplement. SGTC_1456 k015-0012 13 µM 0.706044756240151 0.220004348922222 no 754 0.240080152457341 275 2989616 SGTC_1218 1348-1416 30.7 µM 0.70556014188389 0.220162205724137 no 755 0.240230859275256 264 6787668 SGTC_978 1416-0512 87.4 µM 0.70527790030502 0.220254172160331 no 756 0.240318655353642 279 6814003 SGTC_2479 5617353 43.85 µM 0.704450156616056 0.220524013622263 no 757 0.240576239991085 277 2731746 SGTC_2506 ethyl hematommate 54.16 µM 0.703150798096939 0.220947981665195 no 758 0.240980888920472 261 3940691 An allergen. SGTC_2420 aureobasidin a 50 nM 0.701274804707856 0.22156092240186 no 759 0.241565767102006 257 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3030 9087619 49.47 µM 0.700679233730501 0.221755715543422 no 760 0.241751609248709 264 25236973 SGTC_3247 9135149 49.47 µM 0.699350399345961 0.222190689325067 no 761 0.242166538692965 278 8934436 YOR116C RPO31 SGTC_506 n9-isopropylolomoucine 153 µM 0.699040272938673 0.222292274533552 no 762 0.242263431412814 261 6610355 SGTC_2699 st077704 54.6 µM 0.698901120275612 0.222337864081613 no 763 0.242306913674382 262 645852 SGTC_263 alizarin 107.927 µM 0.698884908531464 0.222343175761189 no 764 0.242311979776308 283 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3080 9117754 49.47 µM 0.698670599097676 0.222413399749771 no 765 0.242378955968386 269 9550191 SGTC_2743 auranofin 4.32 µM 0.69805935535659 0.222613758934883 no 766 0.242570037544954 234 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2295 7971645 200 µM 0.697507682759054 0.222794679642861 no 767 0.242742566536703 264 2978226 YKL099C UTP11 SGTC_3114 9122766 49.47 µM 0.69624887659163 0.223207817950981 no 768 0.24313649165223 241 17176985 SGTC_2798 7813637 45.45 µM 0.695674526725031 0.2233964635086 no 769 0.243316340875064 270 956368 SGTC_2910 7948405 25.97 µM 0.694983173117817 0.223623659286985 no 770 0.243532923427042 257 2971328 SGTC_1376 2910-0861 41.3 µM 0.694595769278547 0.223751027126605 no 771 0.243654332173203 287 1112859 SGTC_2807 7945238 51.95 µM 0.694505969719035 0.223780556664536 no 772 0.243682479181776 274 17148797 SGTC_1333 1482-0047 286 µM 0.693961198439363 0.223959745824308 no 773 0.243853271338932 273 3811116 SGTC_2917 7979103 53.79 µM 0.693668795969822 0.224055958062668 no 774 0.243944969563097 261 2980565 SGTC_596 1155-0152 116 µM 0.693275421694177 0.224185431141966 no 775 0.244068362169574 272 280313 SGTC_1926 methyl fluorone black 53.6 µM 0.693028027303438 0.22426687894978 no 776 0.244145981429844 239 72721 Reacts with homocysteine. SGTC_1508 1080-0625 72.9 µM 0.691739628361743 0.224691320385891 no 777 0.244550427880749 271 767111 SGTC_593 1203-0218 61.7 µM 0.69013246611874 0.225221411098792 no 778 0.245055444036667 269 3666956 SGTC_1635 st007035 42.4 µM 0.69004827257277 0.22524920018874 no 779 0.24508191550205 263 3716403 SGTC_2714 st079313 56.9 µM 0.689225799736199 0.225520769341452 no 780 0.245340591754131 275 2939799 SGTC_2084 5306078 60.6385 µM 0.68622554196733 0.226512982375752 no 781 0.246285446735515 297 679340 SGTC_2311 7694451 200 µM 0.685304475496027 0.226818081325887 no 782 0.246575904109162 291 2163142 SGTC_2126 5251174 33.877 µM 0.68394000411908 0.227270481900092 no 783 0.24700652581109 268 790722 SGTC_1005 4092-0690 4.4 µM 0.682937578658569 0.227603167220372 no 784 0.247323143480731 285 1529343 SGTC_537 1334-0398 209 µM 0.68260593704892 0.227713292891061 no 785 0.247427940751003 280 5846986 SGTC_2930 9013230 14.89 µM 0.681518389445937 0.228074636801455 no 786 0.247771767391408 261 2995857 SGTC_2899 9053889 58.44 µM 0.68138859782445 0.22811778233791 no 787 0.247812817861487 261 6470052 SGTC_853 0419-0306 21 µM 0.680112639495019 0.228542182687549 no 788 0.248216570954079 283 762713 SGTC_1992 st073643 23.3 µM 0.679698543296397 0.228680011739196 no 789 0.248347679289188 283 3161292 SGTC_3244 9134489 49.47 µM 0.679297737979548 0.228813461452783 no 790 0.248474614704582 295 16584271 SGTC_2469 5655019 90.81 µM 0.677493437613195 0.229414751416625 no 791 0.249046466176833 275 2788239 SGTC_2881 9058953 51.95 µM 0.675417439907375 0.230107679912856 no 792 0.249705294196169 239 17122249 SGTC_2690 usnic acid 100 µM 0.675162806044977 0.230192752394706 no 793 0.249786167175697 293 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2825 7998094 58.44 µM 0.674449772637091 0.230431068504163 no 794 0.250012704102956 268 2987815 SGTC_923 1900-2434 73.3 µM 0.674430163405743 0.230437624416932 no 795 0.250018935666516 301 5910570 SGTC_2754 granisetron 64.02 µM 0.673852362038117 0.230630846318276 no 796 0.250202590555504 285 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_270 tamoxifen 5.46 µM 0.673589079296079 0.230718920415667 no 797 0.250286299026581 298 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2736 butenafine 14.65 µM 0.6732836836201 0.23082110578518 no 798 0.250383415539216 280 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2412 st077135 33.4 µM 0.67289656896824 0.23095067063508 no 799 0.250506547571334 302 13258915 SGTC_925 2064-1272 59.6 µM 0.672255786340263 0.231165225770624 no 800 0.250710435889822 279 6815817 SGTC_1428 4049-0204 61.7 µM 0.672116028288625 0.231212036140622 no 801 0.250754916672426 290 X1428 SGTC_1071 trifluoperazine 6.31 µM 0.672008021749814 0.231248215324934 no 802 0.250789294766235 303 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2245 6637752 200 µM 0.67143700065838 0.231439543974207 no 803 0.250971090195523 286 681890 SGTC_1303 1160-0052 261 µM 0.67043296847454 0.231776173027553 no 804 0.251290911981647 272 3562476 SGTC_1972 st070201 17.4 µM 0.669869444145614 0.231965229310165 no 805 0.251470509914678 276 2829099 SGTC_2812 7970281 58.44 µM 0.669427209776808 0.232113654246725 no 806 0.251611499638794 291 2233435 SGTC_2156 5649887 115 µM 0.664930335233662 0.233625916141561 no 807 0.253047526034016 293 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2771 fluoxetine 41.05 µM 0.663759894305306 0.234020419899833 no 808 0.253421999158925 289 3386 A selective serotonin reuptake inhibitor. SGTC_1235 benzylparaben 21.5 µM 0.662957048476289 0.234291236858638 no 809 0.253679031501285 299 7180 SGTC_210 3551-0445 56.827 µM 0.661819639499699 0.23467520586548 no 810 0.254043408996298 288 2865180 YOR207C RET1 SGTC_2170 morpholine 200 µM 0.661732919887077 0.234704495131103 no 811 0.254071201535624 279 121171 Reacts with secondary amines. SGTC_2646 retinol 96.75 µM 0.661328074709329 0.234841257006074 no 812 0.254200970397239 286 445354 A vitamin A analog and teratogen. SGTC_261 5-fluorouridine 15.376 µM 0.658353158604146 0.235847571534755 no 813 0.255155613500282 260 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1969 st069479 40.1 µM 0.658141291349192 0.235919329699585 no 814 0.255223672616511 286 3895485 SGTC_2143 5623677 140.463 µM 0.655641412371528 0.236766931714011 no 815 0.256027436698245 269 5375313 SGTC_2333 9017922 200 µM 0.65494341161906 0.237003892645487 no 816 0.256252094320273 300 3163164 SGTC_467 ro 31-8220 72.8 µM 0.65418371171524 0.237261947591998 no 817 0.256496727097297 289 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_129 0088-0017 176.636 µM 0.650614102840462 0.238476536373672 no 818 0.257647812154624 281 182446 SGTC_1939 st074455 53.6 µM 0.649904293194874 0.238718460051722 no 819 0.257877022419992 306 1644229 SGTC_1796 st049173 110.4 µM 0.64840864932061 0.239228658056579 no 820 0.258360338780052 311 94134 SGTC_1234 0326-0494 15.5 µM 0.648248955451172 0.239283168434525 no 821 0.258411971470859 298 1547813 SGTC_1131 3454-3128 32.3 µM 0.647256320211031 0.239622149613752 no 822 0.258733033059113 273 710982 SGTC_3265 9137266 49.47 µM 0.645940022159824 0.24007206437478 no 823 0.259159099541577 247 17224265 SGTC_1053 3366-3204 134 µM 0.645860126862691 0.240099387652628 no 824 0.259184972154811 307 3632071 YPR165W RHO1 SGTC_1001 4048-4355 44.4 µM 0.644836422219368 0.240449632905197 no 825 0.259516598070386 289 21824233 SGTC_534 k292-0788 63.4 µM 0.644254634166651 0.240648806936233 no 826 0.259705164093424 307 4146317 SGTC_265 mycophenolic acid 32.932 µM 0.637659957074662 0.242912748208171 no 827 0.26184752852609 295 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3212 9128307 49.47 µM 0.637521301349335 0.242960471851829 no 828 0.261892669693168 286 27243542 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.637478562628776 0.242975183031296 no 829 0.26190658464174 284 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1520 flindersine 88 µM 0.636522184017601 0.243304506003372 no 830 0.262218063223599 304 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3194 9111903 49.47 µM 0.635749209489758 0.243570851113903 no 831 0.26246994837503 310 17087251 SGTC_3125 9127534 49.47 µM 0.635486383337355 0.243661449416853 no 832 0.262555622364233 270 1639235 SGTC_2018 5133068 143 µM 0.635357254121144 0.243705967968351 no 833 0.262597720127137 299 785362 SGTC_527 4476-4215 268 µM 0.632719430924468 0.244616343486069 no 834 0.263458439304758 281 4418754 SGTC_2876 9059903 25.97 µM 0.632504571302602 0.244690577232657 no 835 0.263528611165531 280 6916095 SGTC_2840 9008771 71.43 µM 0.631733409612078 0.244957112556755 no 836 0.263780546465851 242 2992978 SGTC_1477 0139-0234 16 µM 0.630439082196039 0.245404819674695 no 837 0.264203673719252 294 620880 SGTC_2256 7954252 200 µM 0.629103834807656 0.245867141405202 no 838 0.264640540037465 309 2972920 SGTC_374 0880-0231 82.3 µM 0.62909294297006 0.24587091456255 no 839 0.264644105139731 301 6833587 SGTC_2705 st078069 42.8 µM 0.62908200226892 0.245874704678526 no 840 0.264647686260542 289 1530061 SGTC_1753 st043925 64 µM 0.628796709536877 0.245973547854045 no 841 0.264741077252165 297 670181 SGTC_375 3970-0961 9.27 µM 0.627100551884747 0.246561642464219 no 842 0.265296662700748 292 2898222 SGTC_159 3970-0959 50 µM 0.626467566926888 0.246781304908063 no 843 0.265504151837792 293 6615653 SGTC_421 streptovitacin 30 mM 0.626084786359748 0.246914190660484 no 844 0.265629665225972 305 91467 include heat shock SGTC_132 0417-1715 25.805 µM 0.622534237564619 0.248148618874132 no 845 0.266795319041466 307 6769098 SGTC_2032 5185112 25.99 µM 0.622219565851299 0.248258180147323 no 846 0.266898751091513 270 5718189 SGTC_1292 0kpi-0043 232 µM 0.62210045361966 0.248299658947145 no 847 0.266937908361435 300 3333905 SGTC_495 decylubiquinone 155 µM 0.618623550264807 0.24951205746259 no 848 0.268082191896173 316 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2911 7942208 15.64 µM 0.618390185799133 0.249593544305399 no 849 0.268159082797732 270 1243384 SGTC_3342 9147791 14.508 µM 0.618350520795852 0.249607396045346 no 850 0.268172153062555 291 1838168 SGTC_319 1348-1596 45.5 µM 0.618192645837226 0.249662532896906 no 851 0.26822417861075 320 5380505 SGTC_2127 5253358 187.912 µM 0.617775421974296 0.249808276878978 no 852 0.268361693507129 297 20612 SGTC_46 0329-0187a 2.197 µM 0.616807816738675 0.250146452990567 no 853 0.268680747760199 310 46494817 SGTC_1396 3511-0007 98.6 µM 0.61177484190871 0.251909376881753 no 854 0.27034336850234 292 X1396 SGTC_2457 5731572 11.68 µM 0.611231409814214 0.252100118894451 no 855 0.270523196024313 323 2865357 SGTC_2885 9057732 51.95 µM 0.61039893459903 0.252392461315339 no 856 0.27079878686686 306 6471414 SGTC_650 1328-0195 38 µM 0.609317621835362 0.252772455265153 no 857 0.271156964476729 302 2780821 SGTC_2946 9065502 71.43 µM 0.608887076961589 0.252923840757845 no 858 0.271299645307167 263 16489101 SGTC_208 k072-0098 12.366 µM 0.608597380473116 0.253025728871507 no 859 0.271395670607082 305 5948901 SGTC_63 0099-0242 26.702 µM 0.608439795909464 0.253081161440778 no 860 0.271447912057877 295 3898502 YLR359W ADE13 SGTC_2908 7930301 100 µM 0.608285094613839 0.2531355859939 no 861 0.27149920253821 290 2223178 SGTC_2853 9015042 58.44 µM 0.604483614780441 0.254474894116682 no 862 0.272761079814554 279 6457456 SGTC_3288 9119690 36.221 µM 0.603513398542185 0.254817307011964 no 863 0.273083602448499 324 17595618 YKL019W RAM2 SGTC_2845 9003024 42.97 µM 0.602469325814407 0.255186054900446 no 864 0.273430887728621 284 2990173 SGTC_72 0744-0168 198.391 µM 0.60147045001595 0.255539101043226 no 865 0.273763343892139 337 677577 SGTC_1783 st039459 87.517 µM 0.60145127634408 0.255545880347622 no 866 0.27376972742678 341 729761 SGTC_2915 7971052 15.16 µM 0.601103536419736 0.255668848309764 no 867 0.273885514052104 281 5741558 SGTC_2982 9019404 25.97 µM 0.599478328665642 0.256243964480266 no 868 0.274426978673479 265 22333232 SGTC_2291 7917025 104.35 µM 0.598342513917563 0.256646297991499 no 869 0.274805707366074 298 2964612 SGTC_802 4112-3352 742 µM 0.598326030251469 0.256652139332003 no 870 0.274811205613948 276 704594 SGTC_1722 st034304 3.6505 µM 0.598045464507203 0.256751574435533 no 871 0.274904798694068 313 4036148 YLR033W RSC58 SGTC_1615 st002656 86.5 µM 0.597132809369812 0.257075166553979 no 872 0.275209357180013 295 1584458 SGTC_2750 bromebric acid 70.15 µM 0.596677708421906 0.257236606920934 no 873 0.275361289137888 305 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1445 4239-0156 97.7 µM 0.5966541868913 0.257244952270053 no 874 0.275369142741913 330 4008346 SGTC_1129 3453-1384 223 µM 0.595249971820624 0.257743417290181 no 875 0.275838195724094 329 1084452 SGTC_1899 st063254 59.6 µM 0.595247936438607 0.257744140169103 no 876 0.275838875891948 300 3093813 SGTC_1135 dihydrocapsaicin 536.708 nM 0.59518236034309 0.257767430501366 no 877 0.275860790033517 340 107982 A Capsaicinoid. SGTC_3327 9140648 26.9345 µM 0.592933114158082 0.258566944772648 no 878 0.276612957837743 330 8029710 SGTC_295 k015-0027 31 µM 0.592712217210875 0.258645533723375 no 879 0.2766868819014 307 3887424 SGTC_1658 st012944 20 µM 0.591423112383647 0.259104407679493 no 880 0.277118479075588 300 24207260 SGTC_870 0573-2213 57.6 µM 0.591207913031556 0.259181051720639 no 881 0.277190560708363 289 3916321 SGTC_2168 5727979 200 µM 0.591138882479249 0.259205639688215 no 882 0.277213684630389 299 695210 SGTC_2785 7756463 72.73 µM 0.591044083386389 0.259239408107664 no 883 0.277245442061103 340 2201551 SGTC_1019 4262-0212 3.4 µM 0.589722270415123 0.259710488346344 no 884 0.277688431003015 311 4677213 SGTC_1484 3473-2379 286 µM 0.58886436868909 0.260016471758528 no 885 0.277976130836866 308 671917 SGTC_1339 1486-1321 22.7 µM 0.588820090821342 0.260032269161995 no 886 0.277990983494787 311 3469382 SGTC_565 1418-0001 44.5 µM 0.588236869188445 0.260240396443633 no 887 0.278186656679988 317 2862145 SGTC_3230 9131665 49.47 µM 0.587301583289235 0.260574339784283 no 888 0.278500588983385 316 15943720 SGTC_29 0299-0004 12.984 µM 0.58664602592177 0.260808537634521 no 889 0.278720732162296 295 16871 A napthoquinone isolated from Swertia calycina. SGTC_1961 st076550 68.7 µM 0.58643063580951 0.260885509373847 no 890 0.278793080951546 312 1579337 SGTC_307 1501-1223 22.3 µM 0.585873288965042 0.261084736877827 no 891 0.278980334232485 308 2830329 SGTC_1356 1502-0781 85.8 µM 0.585524814584592 0.261209341191279 no 892 0.279097443157832 305 567702 SGTC_69 0096-0274 206.684 µM 0.584504912751945 0.261574203969413 no 893 0.279440330485376 327 6741392 SGTC_638 3970-0837 4.09 µM 0.583118296831199 0.26207067542727 no 894 0.279906833688869 301 4118451 YLR208W SEC13 SGTC_2153 5569715 200 µM 0.582690441570126 0.262223964485477 no 895 0.280050854480181 315 2054701 SGTC_1306 1185-0270 9.02 µM 0.578620833857868 0.26368428854023 no 896 0.281422521954401 318 1548076 SGTC_356 1634-0012 32.5 µM 0.578613298243214 0.263686996437125 no 897 0.281425064848939 332 735457 SGTC_913 3487-1245 167 µM 0.576591066736548 0.264414190597314 no 898 0.28210786765433 293 4016153 SGTC_2463 5473429 200 µM 0.574613355587038 0.265126361205693 no 899 0.282776408753941 322 5399405 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.574446136000624 0.265186621348406 no 900 0.282832970171773 323 688788 SGTC_793 0488-0545 106 µM 0.57305336423931 0.265688798077226 no 901 0.283304281155195 321 292548 SGTC_2083 5306046 65.942 µM 0.572777969543163 0.265788151245385 no 902 0.283397518712079 305 539837 SGTC_1458 k015-0034 6.33 µM 0.572705134521819 0.265814430826401 no 903 0.28342218017762 321 3598957 SGTC_342 k048-0088 23.3 µM 0.57171200659502 0.266172892355492 no 904 0.283758549456046 302 6820570 SGTC_893 0958-0369 48.9 µM 0.570669591595242 0.266549406741449 no 905 0.284111817601412 322 6819948 SGTC_2596 sinensetin 100 µM 0.569840434348587 0.26684908584454 no 906 0.284392964098951 315 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_705 1124-0212 310 µM 0.567524814097521 0.267686912128387 no 907 0.285178836319347 348 9554485 SGTC_3009 9080819 71.4286 µM 0.566926652646859 0.267903551208062 no 908 0.285382007655249 308 17027216 SGTC_1557 sumaresinolic acid 42.3 µM 0.565116375443499 0.268559725768014 no 909 0.285997305505783 308 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1825 st052143 62.6 µM 0.564630654793977 0.26873592319053 no 910 0.286162505046262 323 674173 SGTC_2834 9001755 58.44 µM 0.563987650654921 0.268969265220548 no 911 0.286381268320679 335 2989575 SGTC_2802 7925815 54.55 µM 0.563858623566069 0.269016100563448 no 912 0.286425175558953 315 1262923 SGTC_1268 0828-0275 2.46 µM 0.562281360062477 0.269588959658242 no 913 0.286962168072337 328 745337 SGTC_316 k060-0003 58.6 µM 0.561789186836043 0.26976784107303 no 914 0.287129830127384 320 6152314 SGTC_798 1287-0182 476 µM 0.561513770225351 0.269867967761535 no 915 0.28722367284577 343 1649755 SGTC_2121 5257820 149.641 µM 0.561478559824261 0.26988076971355 no 916 0.287235671134329 305 791256 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.560492103077729 0.270239553503746 no 917 0.287571912296505 314 551469 SGTC_2015 5119600 184 µM 0.560402195562774 0.270272265585909 no 918 0.287602567195715 336 2828786 SGTC_1652 st011932 78 µM 0.560048092010753 0.270401122393341 no 919 0.287723317492157 308 1551076 SGTC_1550 gossypolone 36.6 µM 0.559464353105027 0.270613609556534 no 920 0.287922426359323 310 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1431 4049-0260 9.09 µM 0.559216563213566 0.270703832917599 no 921 0.288006965257864 325 3854841 SGTC_18 0111-0177 500 nM 0.55697333210623 0.271521303933743 no 922 0.288772824887076 319 721752 SGTC_525 k781-2675 26.7 µM 0.555553920628155 0.272039195628879 no 923 0.289257919723306 317 3651118 YDL195W SEC31 SGTC_2014 4013930 200 µM 0.555531250834978 0.272047470996516 no 924 0.28926567040675 326 64556 SGTC_1412 3909-8563 178 µM 0.555302515534869 0.272130975395134 no 925 0.289343879267385 341 23767530 SGTC_826 1683-5028 118 µM 0.55521979452593 0.272161177491746 no 926 0.289372165567688 320 722377 SGTC_1905 st060207 84.5 µM 0.55470822228016 0.272347993582405 no 927 0.289547125633462 303 1948547 SGTC_2634 4'-methoxyflavone 100 µM 0.554355661815761 0.27247677877701 no 928 0.289667731842025 316 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3154 9100113 49.47 µM 0.553946278208443 0.272626358571798 no 929 0.289807806064806 322 25237525 SGTC_678 1218-2179 85.9 µM 0.5534881348233 0.272793802433768 no 930 0.28996460154645 332 6820081 YOR116C RPO31 SGTC_1320 1313-0481 95.3 µM 0.553186691973155 0.272904002651753 no 931 0.290067789360388 305 6813365 YLR208W SEC13 SGTC_3157 9099274 49.47 µM 0.552275306038557 0.273237317532437 no 932 0.290379873275424 308 17217662 SGTC_1666 st014829 29 µM 0.552147640954131 0.273284023700421 no 933 0.290423601904601 322 3858230 SGTC_2066 5222451 176 µM 0.550781864928101 0.273783939068744 no 934 0.290891608687484 313 2281147 SGTC_1171 0368-0077 21.4 µM 0.549470159342131 0.274264488390873 no 935 0.291341418855799 338 3239779 SGTC_442 cape 100 µM 0.549219475055838 0.274356375105584 no 936 0.291427420457865 312 5281787 SGTC_2756 carbadox 75.1 µM 0.548551809233093 0.274601177837467 no 937 0.291656532582912 326 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3217 9129673 49.47 µM 0.546018301496436 0.275531079032925 no 938 0.29252667847722 316 17248312 SGTC_1330 1469-0054 61.8 µM 0.544774498356539 0.275988171900899 no 939 0.29295430996639 340 7102664 SGTC_179 1273-0063 6.77 µM 0.544459253383705 0.27610408234207 no 940 0.293062740282764 351 3108139 SGTC_1860 st056228 74.6 µM 0.543450925090382 0.276474988621346 no 941 0.293409685520386 357 688679 SGTC_2852 9023854 51.95 µM 0.542383145101851 0.276868029940401 no 942 0.2937772941901 357 19798528 SGTC_1847 st056231 15 µM 0.541402138015883 0.277229371863994 no 943 0.294115216934918 319 5393180 SGTC_1158 4092-0494 91.8 µM 0.54099039087709 0.277381102570875 no 944 0.294257102972567 327 1148199 SGTC_2455 5377712 9.75 µM 0.539938516354154 0.277768907405422 no 945 0.294619717235514 298 2243908 SGTC_2819 7996655 46.38 µM 0.53958562199113 0.277899071696758 no 946 0.294741417195928 319 6456960 SGTC_630 4356-0227 183 µM 0.538428413166395 0.278326114338195 no 947 0.295140657437029 341 779312 SGTC_1103 duloxetine 36.1 µM 0.53775134225355 0.278576120810407 no 948 0.295374364183244 325 60835 A selective serotonin reuptake inhibitor. SGTC_3292 9120825 59.784 µM 0.537230513438461 0.278768509739295 no 949 0.295554198259622 332 24824900 SGTC_1167 k781-0610 148 µM 0.536512549205223 0.279033824486397 no 950 0.295802182620776 320 4525169 SGTC_303 1348-1668 34.2 µM 0.535812951220348 0.279292470288479 no 951 0.296043915199283 324 5380509 SGTC_463 ikarugamyin 104 µM 0.533874619868163 0.280009691583193 no 952 0.296714141335216 350 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3271 9137798 49.47 µM 0.532852147787559 0.280388386052657 no 953 0.297067966097416 309 6498326 SGTC_1609 st001574 46.4 µM 0.532386910714695 0.280560778632667 no 954 0.297229024458201 346 3960012 SGTC_3084 9116877 49.47 µM 0.532151648525067 0.280647974044933 no 955 0.297310484023422 318 27241325 SGTC_1200 1643-0193 18.4 µM 0.531855535073946 0.28075774144024 no 956 0.297413027842973 349 5403974 SGTC_2837 9008476 45.46 µM 0.530337680241163 0.281320726432919 no 957 0.297938913032131 337 2992805 SGTC_2543 pimpinellin 60.67 µM 0.529646649545904 0.281577215868451 no 958 0.298178472059987 333 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1950 st077106 7.18 µM 0.528565463534856 0.281978745150828 no 959 0.298553461812195 309 13831864 SGTC_2985 9022375 71.43 µM 0.528481079594173 0.28201009513443 no 960 0.298582737873141 321 4939335 SGTC_745 0469-0705 296 µM 0.525899429461008 0.282970029833997 no 961 0.299479042682378 362 3486736 SGTC_2194 5927483 104.545 µM 0.524870477434593 0.283353061693871 no 962 0.299836616875349 280 760979 SGTC_846 0335-0850 148 µM 0.52457112886633 0.283464542163128 no 963 0.299940680675913 319 6819598 SGTC_1935 st074532 41.6 µM 0.522708168940197 0.284158799605882 no 964 0.300588676324289 339 2829742 SGTC_2458 5808907 16.39 µM 0.522109452419944 0.284382092014399 no 965 0.300797062756725 354 2731747 SGTC_1203 3992-3522 103 µM 0.521729484965031 0.284523845040191 no 966 0.300929346224159 372 5322312 SGTC_2436 5633522 8.09 µM 0.521021232159438 0.284788160287743 no 967 0.301175990327234 324 5724242 SGTC_2610 ononetin 44.17 µM 0.520700664773865 0.284907832416055 no 968 0.301287655616206 318 259632 SGTC_1901 st060216 58.6 µM 0.519924372700787 0.285197732054361 no 969 0.301558143612716 328 688792 SGTC_1768 st044301 37.178 µM 0.519735918206474 0.285268129973194 no 970 0.301623824392918 351 3931349 SGTC_3128 9127691 49.47 µM 0.519494577289241 0.285358295911796 no 971 0.301707946717991 348 41316314 SGTC_740 k014-0057 261 µM 0.518981834382844 0.285549903767313 no 972 0.301886704526399 353 4012779 SGTC_82 0054-0107 293.755 µM 0.518604734988574 0.285690861814797 no 973 0.302018203234116 315 3104697 SGTC_758 0868-0029 16 µM 0.518487222752229 0.285734794121434 no 974 0.302059186300548 311 762687 SGTC_2326 6164455 177.58 µM 0.51737733950759 0.286149885773472 no 975 0.302446387560376 356 2888790 SGTC_2402 5553605 200 µM 0.516658882656199 0.286418738241103 no 976 0.302697151806034 328 6758546 SGTC_799 1310-0557 151 µM 0.515785516955906 0.286745720225313 no 977 0.303002109522512 354 5354492 SGTC_3275 9138069 49.47 µM 0.514835183766738 0.287101719214074 no 978 0.30333409848044 327 17617007 SGTC_3270 9137563 49.47 µM 0.513709537982624 0.287523661617805 no 979 0.303727541234209 323 17015724 SGTC_2945 9067681 61.76 µM 0.510101546402778 0.288878070581263 no 980 0.304990160938456 356 16456930 SGTC_1724 st037281 8.293 µM 0.509823385420157 0.288982614368521 no 981 0.305087600336512 321 574124 YDL195W SEC31 SGTC_718 1130-0073 349 µM 0.509632454954774 0.289054383812825 no 982 0.305154491006513 341 6740020 SGTC_2843 9000894 45.46 µM 0.507512124042231 0.289851964514491 no 983 0.305897765850451 285 2242070 SGTC_2407 paclitaxel 400 µM 0.505766927180503 0.290509208816504 no 984 0.306510139240561 384 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1505 k297-0037 20.6 µM 0.5055869975087 0.290577010299573 no 985 0.306573305667015 323 4089396 SGTC_231 b-estradiol 524 µM 0.504111265989584 0.291133377788145 no 986 0.307091595271094 312 450 A steroid. SGTC_393 acivicin 6.25 µM 0.503018724287356 0.291545598593018 no 987 0.307475553848382 335 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1272 0839-0021 27 µM 0.502991589798996 0.2915558400182 no 988 0.307485092574298 363 5027250 SGTC_3179 9107801 49.47 µM 0.501552106710723 0.29209938739995 no 989 0.307991307968581 297 4818259 SGTC_597 k018-0003 82.8 µM 0.501004168377351 0.29230641222946 no 990 0.30818409465426 354 6786234 SGTC_1511 0906-3109 28.5 µM 0.500661044405018 0.292436087799395 no 991 0.308304846385588 332 2882180 SGTC_1349 flufenamic acid 69 µM 0.499381616060533 0.292919853023544 no 992 0.308755283916622 345 3371 A non-steroidal anti-inflammatory. SGTC_2353 9059630 146.67 µM 0.498691538024021 0.293180932828093 no 993 0.308998353410836 341 4779114 SGTC_3297 9117502 71.43 µM 0.498674692250218 0.293187307501577 no 994 0.309004288124933 307 7453720 SGTC_64 000l-0018 272.079 µM 0.497178714843353 0.293753662090279 no 995 0.309531514996202 335 6811119 SGTC_432 NS 1619 61.3 µM 0.496573577057127 0.293982901893001 no 996 0.309744895010555 316 4552 A K+/calcium channel activator. SGTC_502 l-744,832 89.3 µM 0.494896192484642 0.29461876488954 no 997 0.310336699246464 370 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1844 rapamycin 4 nM 0.494076486806819 0.294929729554049 no 998 0.310626081480091 322 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1569 carminic acid 40.6 µM 0.493785007638217 0.295040341930819 no 999 0.310729011178251 325 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_226 1,3-diallylurea 8.28947 mM 0.493317165418255 0.295217921623928 no 1000 0.310894250725841 326 74537 YKL182W FAS1 SGTC_1143 3454-2408 5.08 µM 0.492805274865308 0.295412277169724 no 1001 0.311075091621203 321 X1143 SGTC_801 0866-0028 10.1 µM 0.491737629246629 0.29581783211189 no 1002 0.311452416659407 330 6849771 SGTC_2026 5148700 152 µM 0.490690874620186 0.296215699534671 no 1003 0.311822550820037 322 79838 SGTC_415 dibenzyl ketone 100 µM 0.489414068334564 0.296701340744784 no 1004 0.312274289039879 369 7593 SGTC_1747 st037496 66.6 µM 0.489278549017699 0.296752907754802 no 1005 0.312322252801107 335 723305 SGTC_2212 7123476 200 µM 0.488367603500894 0.297099641801572 no 1006 0.312644742285796 342 1085715 SGTC_118 0083-0097 135.343 µM 0.488065620812327 0.297214626626479 no 1007 0.312751680734888 362 5207356 SGTC_3131 9127911 49.47 µM 0.487730239344771 0.297342352413913 no 1008 0.312870464870721 317 45595681 SGTC_2524 avocatin b 10.57 µM 0.487597142287289 0.297393047693387 no 1009 0.312917610068128 332 6710748 SGTC_946 3434-1334 87.4 µM 0.486804505504774 0.297695036499051 no 1010 0.313198438582111 331 4047976 SGTC_1809 st050081 57.6 µM 0.48627329982657 0.297897500243222 no 1011 0.313386703610093 358 5036894 SGTC_3331 9141060 1.957 µM 0.485815831322467 0.298071910096671 no 1012 0.313548874367656 341 4906567 YPR165W RHO1 SGTC_2887 9044784 58.44 µM 0.485533568433906 0.298179546019658 no 1013 0.313648953417568 338 6465546 SGTC_2879 9041815 71.43 µM 0.482962273098627 0.299160877781294 no 1014 0.314561262012022 327 4942971 SGTC_2611 pyromycin 23.93 µM 0.48181560868116 0.299598972948061 no 1015 0.314968470121313 323 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_154 3389-1638 511.116 µM 0.481757836212789 0.299621053215949 no 1016 0.314988992472216 372 5238686 SGTC_2962 9082311 13.18 µM 0.48013310954111 0.300242315047535 no 1017 0.315566373256462 359 16459453 SGTC_2391 6285546 200 µM 0.480129484068153 0.300243702004291 no 1018 0.315567662148787 340 846083 SGTC_1897 st060201 15 µM 0.479570194463437 0.300457697868673 no 1019 0.315766522124626 330 611878 SGTC_2213 7173844 200 µM 0.479243645098502 0.300582674312289 no 1020 0.315882654080774 344 892728 SGTC_583 1488-1091 88.9 µM 0.479206917969125 0.300596731927946 no 1021 0.315895716622624 359 4303273 SGTC_2625 euphol 100 µM 0.478939303242501 0.300699172660631 no 1022 0.315990904662353 351 6708538 A triterpene alcohol. SGTC_1334 1486-0610 236 µM 0.478772503309928 0.300763030282595 no 1023 0.316050240001301 331 3742339 SGTC_1187 1391-0724 117 µM 0.476297717089931 0.30171119441928 no 1024 0.31693114578219 348 6997986 SGTC_672 1441-0018 53.7 µM 0.476087516982618 0.301791790216379 no 1025 0.317006014917734 335 251141 SGTC_1392 3455-1037 33.9 µM 0.476073507489982 0.301797162138129 no 1026 0.31701100508927 350 981132 SGTC_3097 9117246 49.47 µM 0.475568419994713 0.301990865982836 no 1027 0.317190939128683 326 16423892 SGTC_2426 5582046 32.21 µM 0.475026801572428 0.30219864166389 no 1028 0.317383935093983 340 2251934 SGTC_2839 9003951 25.97 µM 0.474459737887811 0.30241624738306 no 1029 0.317586051234717 336 2990634 SGTC_1140 3229-1848 2.98 µM 0.47389077195131 0.302634653670327 no 1030 0.317788900047497 365 2849525 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.473414137592211 0.302817671453989 no 1031 0.317958872739636 359 165506 SGTC_1866 st057638 64 µM 0.473251464550292 0.302880145895921 no 1032 0.318016892392997 341 688802 SGTC_1398 3558-0053 112 µM 0.47319152905507 0.302903165525911 no 1033 0.318038270365688 358 4532369 SGTC_1482 3346-2049 8.48 µM 0.471394936786368 0.303593552089293 no 1034 0.318679365511216 333 3826804 SGTC_3226 9131256 49.47 µM 0.470588856799759 0.303903537117186 no 1035 0.318967183339367 326 17178073 SGTC_2545 solidagenone 89.61 µM 0.469321327930879 0.304391261565738 no 1036 0.319419986284737 337 6708572 An anti ulcer agent SGTC_1432 4049-0298 68.4 µM 0.469250464022314 0.30441853912474 no 1037 0.319445309158725 370 741646 SGTC_625 k213-0058 121 µM 0.468968748266059 0.304526990390484 no 1038 0.319545987244688 345 3655420 SGTC_3127 9126946 49.47 µM 0.468762418141708 0.304606431580882 no 1039 0.319619732851834 371 27243249 SGTC_360 0957-0399 1.01 µM 0.468730037340612 0.304618899668351 no 1040 0.319631306903211 338 6752301 YPR165W RHO1 SGTC_679 0422-0091 41.4 µM 0.468667137258521 0.304643119721712 no 1041 0.31965379013444 360 627384 YHR062C RPP1 SGTC_2717 st081029 62.2815 µM 0.467847549319978 0.30495878521484 no 1042 0.319946807148312 366 5292846 SGTC_1390 3413-2614 145 µM 0.465513572268645 0.305858514814626 no 1043 0.32078185989856 373 3421432 SGTC_973 1325-0077 65.9 µM 0.465403301873639 0.305901052233995 no 1044 0.320821335041217 368 2835149 SGTC_279 1273-0055 2.93 µM 0.464572535996195 0.306221608939277 no 1045 0.321118801829019 370 2847562 SGTC_1312 1218-2183 165 µM 0.463248763990822 0.306732702019681 no 1046 0.321593033227107 338 6744073 SGTC_2142 5622915 118.518 µM 0.460027751124787 0.307977866890089 no 1047 0.322748150704667 338 5322196 SGTC_1690 st023502 41.2 µM 0.459215453163404 0.308292231566019 no 1048 0.323039727277521 380 24207482 SGTC_172 1112-0046 2.638 µM 0.457016342622203 0.309144007195677 no 1049 0.323829649491876 337 2802135 YIL048W NEO1 SGTC_1004 4084-0029 199 µM 0.45698104218933 0.309157688404972 no 1050 0.32384233592026 368 716894 YLR208W SEC13 SGTC_2934 9036370 36.88 µM 0.456603087611916 0.309304186922442 no 1051 0.323978179760113 358 6462800 SGTC_3071 9117417 49.47 µM 0.45600681544893 0.309535368898135 no 1052 0.324192538627906 362 45595590 YGL055W OLE1 SGTC_3038 9091290 49.47 µM 0.45541904983331 0.309763326566981 no 1053 0.324403896457602 389 25236843 SGTC_3323 9138564 53.9225 µM 0.45494134726712 0.309948651548381 no 1054 0.324575717802584 343 43912313 YNL103W MET4 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.453557049723307 0.310485963220902 no 1055 0.325073836470504 386 7104 SGTC_2352 9027995 87.8 µM 0.451923380404898 0.311120588448627 no 1056 0.325662090222983 363 2997347 SGTC_1856 st057054 55.7 µM 0.451808579589484 0.311165205833368 no 1057 0.325703444201033 376 1266018 SGTC_3235 9132602 49.47 µM 0.451577613133086 0.311254979449882 no 1058 0.325786650298163 352 4912240 SGTC_1707 st032323 6.317 µM 0.450097521331816 0.311830537945745 no 1059 0.3263200619899 335 3132057 YMR211W DML1 SGTC_2919 7978188 46.38 µM 0.449423290317537 0.312092876515991 no 1060 0.32656316664832 329 2980291 SGTC_1806 st050005 60.3 µM 0.447910599484092 0.312681800634986 no 1061 0.327108859202594 343 5194765 SGTC_443 clozapine 122 µM 0.447458282973396 0.312857990501337 no 1062 0.327272101071647 382 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1758 st042942 75.2445 µM 0.445386706676671 0.313665472973185 no 1063 0.328020158607158 359 669317 SGTC_2977 9011197 71.43 µM 0.444643488773118 0.313955390866823 no 1064 0.328288707100708 403 2704722 SGTC_128 0906-2981 13.371 µM 0.442493518582143 0.314794707567573 no 1065 0.329066059712865 361 6740226 SGTC_2254 7938975 95.19 µM 0.441787475975083 0.315070545293663 no 1066 0.32932150108653 357 2969277 SGTC_266 formosanin C 406 nM 0.441163412074207 0.315314441359232 no 1067 0.329547349477618 339 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_712 r015-0009 80.6 µM 0.440956101959967 0.31539547992182 no 1068 0.329622388660784 360 6813872 YLR060W FRS1 SGTC_2833 9001315 45.46 µM 0.438920049996951 0.316191854278113 no 1069 0.330359734084736 340 2989378 SGTC_2866 9034245 58.44 µM 0.438822345566111 0.316230091541019 no 1070 0.330395133822484 388 6462273 SGTC_3050 9093513 49.47 µM 0.436988127898313 0.316948288911684 no 1071 0.331059978992046 357 25236664 SGTC_797 k781-0471 270 µM 0.436307218970721 0.317215078139256 no 1072 0.331306922456028 377 23738129 SGTC_3122 9126309 49.47 µM 0.435901440431311 0.317374112794419 no 1073 0.331454119998264 412 17591206 SGTC_842 0271-0008 11.1 µM 0.435210704138389 0.317644906993534 no 1074 0.331704746809392 344 1221709 SGTC_1112 tnp00069 1.16933 µM 0.433760368087052 0.318213809865381 no 1075 0.332231231957922 373 145826 SGTC_2070 5230947 200 µM 0.43283278504779 0.318577884854988 no 1076 0.332568126785302 398 2835538 SGTC_2681 menadione 3.18 µM 0.432321512536686 0.318778633504191 no 1077 0.332753876974285 378 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_21 0849-0113 22.993 µM 0.432046243387465 0.318886738619772 no 1078 0.332853901894342 352 1560156 SGTC_2958 9077254 16.72 µM 0.431738140480445 0.319007756654983 no 1079 0.332965871770442 335 16457351 SGTC_2906 7926292 26.41 µM 0.431634935496365 0.319048298284149 no 1080 0.333003381560987 376 2966319 SGTC_3139 9095020 49.47 µM 0.431134323129831 0.319244982682511 no 1081 0.333185352535054 336 25236292 SGTC_772 k072-0172 35.3 µM 0.43056954214919 0.319466939219589 no 1082 0.333390695744806 329 5861980 SGTC_2167 5876490 200 µM 0.430535428077756 0.319480347978112 no 1083 0.333403100547315 376 686534 SGTC_699 0375-0592 111 µM 0.429974570657373 0.319700830478784 no 1084 0.333607069643786 352 762578 SGTC_2086 5274770 176.623 µM 0.429865838471109 0.319743582310816 no 1085 0.333646618375561 359 689278 SGTC_1000 4048-0884 8.67 µM 0.42949479737682 0.319889488019943 no 1086 0.33378158961264 372 13040088 SGTC_2378 9074213 121.43 µM 0.42940571753832 0.31992452132704 no 1087 0.333813996816328 354 657714 SGTC_2252 omeprazole 400 µM 0.429370318043157 0.319938443681774 no 1088 0.333826875480358 364 4594 A proton pump inhibitor. SGTC_318 1488-0629 67.2 µM 0.42862993479308 0.320229688934677 no 1089 0.334096278602073 394 3662576 SGTC_2820 7989630 71.43 µM 0.428474632793917 0.320290794289927 no 1090 0.334152799166211 338 2984098 SGTC_505 gw-5074 63.9 µM 0.428382145304766 0.320327186870177 no 1091 0.334186460822944 382 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_865 0488-0499 301 µM 0.427569968987187 0.320646841487885 no 1092 0.334482116980156 342 9634651 SGTC_1244 0416-0015 52.5 µM 0.426801675434582 0.320949347294862 no 1093 0.334761893033428 369 96201 SGTC_2641 levomentholum 100 µM 0.426310606701889 0.321142761654919 no 1094 0.334940765037847 368 16666 SGTC_629 3448-6466 76.7 µM 0.425722502711436 0.321374458581898 no 1095 0.335155031456851 382 573744 SGTC_2647 atorvastatin 60.16 µM 0.424922279882727 0.321689836198425 no 1096 0.33544666618886 370 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3214 9129694 49.47 µM 0.424263905076829 0.321949406161649 no 1097 0.335686679932743 405 17158655 SGTC_2710 st078562 53.7235 µM 0.423678979638998 0.32218009097903 no 1098 0.335899973602107 381 17250908 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.422222715423253 0.322754714729991 no 1099 0.336431231381491 370 2724278 An inhibitor of dopamine biosynthesis. SGTC_2859 9028643 45.46 µM 0.421809000134079 0.322918038943413 no 1100 0.336582217937344 346 17151580 SGTC_939 1165-0479 45.3 µM 0.419934143245729 0.32365861222267 no 1101 0.337266782194989 398 1377347 SGTC_2739 tacrine 100.86 µM 0.414721057264911 0.325721460580769 no 1102 0.339173057751322 364 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2363 9053361 176 µM 0.413538569695828 0.326190124149913 no 1103 0.339606035039865 393 6469797 YMR079W SEC14 SGTC_1730 st033808 45.1 µM 0.413228949983632 0.32631288329383 no 1104 0.339719439781821 372 1045166 SGTC_2186 6124449 200 µM 0.412978132509055 0.326412342111256 no 1105 0.339811317604344 377 3834182 YLR033W RSC58 SGTC_1757 st041620 31.8375 µM 0.412357886667205 0.326658346536984 no 1106 0.340038562876669 370 5289815 SGTC_35 0133-0054 64.071 µM 0.411722014591784 0.326910626965785 no 1107 0.340271593621327 363 99677 SGTC_3061 glucosamine 200 µM 0.409763922695604 0.327687990969017 no 1108 0.340989566788363 370 91431 and experimental redox chemotherapeutic SGTC_3185 9108267 49.47 µM 0.408599326509969 0.328150691272296 no 1109 0.341416862498412 370 4910486 SGTC_3313 9133968 57.047 µM 0.404916489423549 0.329615635647425 no 1110 0.342769448612294 375 1494643 SGTC_1084 voriconazole 435 nM 0.404396692509977 0.329822609771047 no 1111 0.342960515996658 390 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1280 0880-0253 10.1 µM 0.403140507946056 0.330323015765649 no 1112 0.343422431117244 380 6836607 SGTC_614 0462-0418 107 µM 0.402407970529711 0.330614965090462 no 1113 0.343691902533903 366 5188303 SGTC_1607 st000305 50.6 µM 0.401867192712276 0.330830555689189 no 1114 0.34389088419101 392 5457690 SGTC_1810 st050138 53 µM 0.401211846292687 0.331091896291422 no 1115 0.344132079843363 411 3444541 SGTC_379 3970-0972 5.9 µM 0.401094187554747 0.331138825241455 no 1116 0.344175390034908 357 2898042 YBL034C STU1 SGTC_1003 4049-0218 100 µM 0.40056653652137 0.331349314888151 no 1117 0.344369643555101 366 295161 SGTC_1987 st072290 61.9 µM 0.399644806102102 0.331717137828646 no 1118 0.34470907498637 395 54697379 SGTC_2400 5203494 178.7 µM 0.399625913696771 0.331724678673072 no 1119 0.344716033509538 368 6777674 SGTC_438 sphingosine 6.67 µM 0.398821848390625 0.332045681994712 no 1120 0.345012238598638 354 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1257 0669-0121 16 µM 0.398801296667735 0.332053888382224 no 1121 0.345019810777905 381 4307855 SGTC_344 k064-0035 6.43 µM 0.39758174175914 0.33254100577441 no 1122 0.345469260688367 384 5088750 SGTC_1109 tnp00067 928.257 nM 0.396752815611358 0.332872258898714 no 1123 0.345774874296127 356 676295 SGTC_1968 st069590 43.6 µM 0.396074464937785 0.333143436576716 no 1124 0.346025047610566 376 6384066 SGTC_564 3555-0129 330 µM 0.394386418200776 0.333818629182316 no 1125 0.346647884816662 381 563260 SGTC_1793 st048256 72.231 µM 0.394255200322541 0.333871136886668 no 1126 0.346696317562417 391 672022 SGTC_2525 harmine 47.85 µM 0.393513058994915 0.334168170862899 no 1127 0.346970290350294 410 5280953 A monoamine oxidase inhibitor SGTC_1876 myriocin 605 nM 0.392783754129811 0.334460168400869 no 1128 0.347239602322114 401 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1357 1503-1303 39.5 µM 0.389350831499314 0.335835977745825 no 1129 0.348508319399134 357 292895 SGTC_2792 7535235 81.82 µM 0.389295150432568 0.335858311201505 no 1130 0.348528911662601 362 1281891 SGTC_1309 pyrazolanthrone 13.4 µM 0.389156376867269 0.335913975252207 no 1131 0.348580235571128 407 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_654 1124-0271 80.9 µM 0.385890095482437 0.33722516423023 no 1132 0.349789033122581 385 5403748 SGTC_2041 5107442 45.335 µM 0.385618937012852 0.337334105049854 no 1133 0.349889453143545 375 793005 SGTC_1382 3002-2117 298 µM 0.385155947805004 0.337520147443853 no 1134 0.350060939457848 402 1497314 SGTC_2847 9005661 71.43 µM 0.383293109853458 0.338269090398504 no 1135 0.350751223717705 384 2991449 SGTC_2999 9069765 71.4286 µM 0.382439637536836 0.338612437973213 no 1136 0.351067647126328 386 2097066 SGTC_2487 5918373 44.05 µM 0.382111147350659 0.338744623681438 no 1137 0.351189461844637 411 2876279 SGTC_199 4063-0024 41.6 µM 0.381125069422443 0.339141544468486 no 1138 0.351555223032419 396 306215 SGTC_2856 9022925 19.48 µM 0.380396268023168 0.339435019889689 no 1139 0.351825642238584 367 4944862 SGTC_2362 9071156 126 µM 0.379226622547408 0.339906218963935 no 1140 0.352259791771538 373 653133 SGTC_380 3970-0968 6 µM 0.379191330340243 0.339920440545306 no 1141 0.352272894544997 381 2891601 SGTC_2309 7664088 163.95 µM 0.378966938487901 0.340010868299544 no 1142 0.352356207564564 406 704922 SGTC_3025 9087895 49.47 µM 0.378927590266225 0.340026726202451 no 1143 0.352370817645032 384 17173641 SGTC_2263 7948595 193.29 µM 0.377828692781963 0.340469712030564 no 1144 0.352778928599157 394 2971371 SGTC_66 0109-0187 42.4 µM 0.377347487431544 0.34066376413466 no 1145 0.352957693077957 347 759417 SGTC_1278 0874-0585 172 µM 0.377168327370535 0.340736023458674 no 1146 0.35302425810387 370 766306 SGTC_2140 5586273 200 µM 0.377021784059426 0.340795132051826 no 1147 0.353078708065747 381 854421 SGTC_3086 9117350 49.47 µM 0.376091316098271 0.341170529671625 no 1148 0.353424504984169 368 2679265 SGTC_1194 1488-0194 225 µM 0.372397415977213 0.342662383215712 no 1149 0.354798488777369 390 1391452 SGTC_2941 9056145 11.23 µM 0.370982956069689 0.343234292355504 no 1150 0.355325113210656 414 2119517 SGTC_3306 9127676 59.7925 µM 0.369809688065218 0.343708952916443 no 1151 0.355762148086779 347 41905287 SGTC_2016 5121758 140 µM 0.369424826447013 0.343864707328835 no 1152 0.355905547930661 386 2795203 SGTC_2663 amphotericin b 100 µM 0.368540079989428 0.344222866779082 no 1153 0.356235282675786 390 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2104 5389443 200 µM 0.367659069309667 0.34457965281864 no 1154 0.356563731992364 391 2244536 SGTC_686 1319-0111 510 µM 0.367290008615359 0.344729153768242 no 1155 0.356701353030498 414 4562600 SGTC_833 3852-0053 558 µM 0.36643324523017 0.345076309222201 no 1156 0.35702090806071 388 3123681 SGTC_1122 capsaicin 818.572 nM 0.36623195541462 0.345157889596411 no 1157 0.357095999564189 409 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1526 st051518 75 µM 0.365401296429671 0.345494621916031 no 1158 0.357405936822217 379 673993 SGTC_535 2293-4129 48.2 µM 0.364696273534073 0.345780519884794 no 1159 0.357669070298928 415 396118 YIL048W NEO1 SGTC_1630 st005209 31.3 µM 0.364359985185315 0.345916921141366 no 1160 0.357794605983443 404 3367314 SGTC_1270 0831-1170 17.3 µM 0.364265129785208 0.345955398870611 no 1161 0.357830018072995 390 6764716 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.363596275520283 0.346226762173456 no 1162 0.358079754200056 407 65057 A dermal irritant. YDR527W RBA50 SGTC_940 3232-1287 54.8 µM 0.363557578481927 0.346242464507813 no 1163 0.3580942047207 404 1585493 YIL048W NEO1 SGTC_491 tetrandrine 80.3 µM 0.363117134861488 0.346421204633118 no 1164 0.358258692600698 397 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1208 2323-2347 50.3 µM 0.362065703899649 0.346848032889745 no 1165 0.358651465858903 413 5412760 SGTC_174 3553-0389 74.3 µM 0.362034164409331 0.346860839347847 no 1166 0.358663250084354 367 738071 SGTC_2880 9042983 58.44 µM 0.359365899012914 0.347944907830964 no 1167 0.359660690913955 394 6464714 SGTC_3254 9136651 49.47 µM 0.358124025284644 0.348449883709082 no 1168 0.36012525012656 418 16454030 SGTC_3096 9117468 49.47 µM 0.357871866867728 0.348552450265457 no 1169 0.360219602622767 393 41316311 SGTC_749 1000-0129 128 µM 0.35783458579872 0.348567615445629 no 1170 0.36023355315507 404 708470 SGTC_3263 9137018 49.47 µM 0.357687538377876 0.348627433703555 no 1171 0.360288579942055 417 43844957 SGTC_588 3970-1144 52.9 µM 0.357653321029473 0.348641353713482 no 1172 0.360301384871086 381 1888707 SGTC_2686 alizarin 95.37 µM 0.355450972297064 0.349537722367375 no 1173 0.361125884135011 349 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1480 1070-0044 41.2 µM 0.35489930343944 0.349762386473079 no 1174 0.361332515164613 379 3124987 SGTC_859 0439-0102 54.6 µM 0.354831702137116 0.349789920351859 no 1175 0.361357838440089 402 610143 SGTC_1170 0310-0127 64.8 µM 0.354042883645356 0.350111262945731 no 1176 0.361653372707044 427 774975 SGTC_1328 1441-0025 69.2 µM 0.352927711472271 0.350565736029835 no 1177 0.362071317596721 387 4562601 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.352191837175052 0.350865748709436 no 1178 0.362347199134358 386 75037 A free radical scavenger. SGTC_1867 st057372 64 µM 0.351888446395485 0.350989466869712 no 1179 0.362460962097022 386 688837 SGTC_544 k015-0020 52.4 µM 0.350024654226569 0.351749839248447 no 1180 0.363160097603766 372 3008304 SGTC_2258 7960471 200 µM 0.349907180022576 0.351797785178904 no 1181 0.363204179190624 411 2974708 SGTC_2035 5154463 94.595 µM 0.349382909887502 0.352011789554105 no 1182 0.363400930925406 432 2769623 SGTC_2490 carminic acid 95.39 µM 0.348998475547758 0.352168743474188 no 1183 0.363545227019566 391 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2516 gossypol 71.55 µM 0.348870659385454 0.352220932862113 no 1184 0.36359320666174 396 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2077 5212015 200 µM 0.34874991339007 0.352270237944081 no 1185 0.363638534269322 409 780900 SGTC_2432 5630864 12.22 µM 0.348603767105166 0.352329918230642 no 1186 0.363693399606502 398 5714970 SGTC_669 0108-0021 26.2 µM 0.348513633638838 0.352366726939521 no 1187 0.36372723835035 416 17201 SGTC_1974 st069448 26.9 µM 0.347868609784072 0.35263018214698 no 1188 0.363969430210646 386 6323587 YNR016C ACC1 SGTC_2776 terbinafine 19.92 µM 0.347396818865126 0.352822926423791 no 1189 0.364146611443953 370 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.345906657976798 0.353431960923031 no 1190 0.364706432417973 392 17037758 SGTC_2886 9058944 51.95 µM 0.344292679196825 0.354092023837215 no 1191 0.365313094650176 387 4949929 SGTC_1830 st055982 50.3 µM 0.344156920872092 0.354147564443782 no 1192 0.36536413887399 429 455313 An antimicrobial agent. SGTC_2648 atorvastatin 78.68 µM 0.343185697369233 0.354544995840313 no 1193 0.365729381940505 418 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1136 pergolide 1.05886 µM 0.343129198033347 0.354568120640361 no 1194 0.365750633107974 407 47811 A dopamine receptor agonist. SGTC_2760 etidronate 98.04 µM 0.342081155210086 0.354997174666886 no 1195 0.366144909434096 399 3305 A chelator and antioxidant. SGTC_2873 9040596 71.43 µM 0.341480797212855 0.355243035708587 no 1196 0.366370829325816 427 6463863 SGTC_539 4859-0462 2.54 µM 0.341116417140341 0.355392287511024 no 1197 0.36650797128262 386 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3291 9121177 71.43 µM 0.340176638055526 0.355777327801025 no 1198 0.366861755169396 372 17015612 SGTC_2759 disulfiram 3.38 µM 0.340033533603425 0.355835972566266 no 1199 0.366915637388095 378 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2130 NSC 7 2.4545 µM 0.339648036969416 0.355993967568457 no 1200 0.367060799051751 386 21448 SGTC_979 1426-2828 121 µM 0.339471110873859 0.356066488646931 no 1201 0.367127428271724 400 747872 SGTC_873 0591-4978 488 µM 0.339307158368123 0.35613369656781 no 1202 0.367189175294499 431 3305145 SGTC_3108 9121785 49.47 µM 0.338993270322584 0.356262379000503 no 1203 0.367307399918562 419 17140271 SGTC_1997 st073024 93.8 µM 0.338266323453333 0.356560463036105 no 1204 0.36758124971566 414 686268 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.335890467697206 0.357535291377527 no 1205 0.368476732776883 432 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2826 7992541 19.48 µM 0.334636978773766 0.358049980935139 no 1206 0.36894947327477 446 2985066 SGTC_3081 9117243 49.47 µM 0.33356071690077 0.358492106070409 no 1207 0.36935553268981 412 45595589 SGTC_14 0354-0009 295 µM 0.330100895299339 0.35991467315375 no 1208 0.370661863381638 425 1713507 SGTC_1022 4477-0945 21.3 µM 0.329900280127152 0.359997219416152 no 1209 0.3707376559146 387 4648966 SGTC_2779 methotrexate 400 µM 0.329245094730287 0.360266851199203 no 1210 0.370985220281613 426 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2624 nerol 100 µM 0.328701821492547 0.360490479928791 no 1211 0.371190538709626 410 637566 A natural product oil. SGTC_557 1315-0110 16.2 µM 0.328265399051005 0.360670160010292 no 1212 0.371355501740831 389 6833801 SGTC_3340 9146634 11.102 µM 0.327314921929179 0.3610615886616 no 1213 0.371714853712462 419 4907387 SGTC_2201 6605497 169.863 µM 0.326706980498757 0.361312029468534 no 1214 0.371944760031569 407 670741 SGTC_968 1309-0633 340 µM 0.325370479860646 0.361862808305542 no 1215 0.372450347363256 411 3761976 SGTC_1163 k060-0048 49.9 µM 0.324585103197274 0.362186599701457 no 1216 0.372747551606448 382 6809982 SGTC_185 k048-0037 25.491 µM 0.32421484713844 0.362339281353839 no 1217 0.372887691141742 404 6827589 SGTC_886 0866-0150 153 µM 0.32328796752947 0.362721592588241 no 1218 0.373238582843321 419 271463 SGTC_133 0724-0033 378.92 µM 0.323221126795824 0.362749167768711 no 1219 0.37326389101653 428 280309 SGTC_2384 9036245 200 µM 0.321905756701608 0.363291969075327 no 1220 0.373762045960306 400 6462766 SGTC_1932 st074806 40.9 µM 0.321518978254516 0.363451629571246 no 1221 0.373908566273941 439 17251235 SGTC_2746 daunorubicin 9.88 µM 0.320778997493701 0.363757156566579 no 1222 0.374188938275136 416 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1750 st081859 2.357 µM 0.317820733175774 0.364979443588507 no 1223 0.37531046135542 414 5291695 SGTC_554 4483-2211 187 µM 0.316885778537209 0.365366031612776 no 1224 0.375665136719157 392 747107 SGTC_1104 tacrolimus 29.8 µM 0.31625289972063 0.36562779404917 no 1225 0.375905279181266 407 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.316190351681412 0.365653667689917 no 1226 0.375929015309781 395 688761 SGTC_2761 levamisole 97.89 µM 0.315384259674256 0.36598717061209 no 1227 0.376234958221029 409 26879 An alkaline phosphatase inhibitor. SGTC_2232 chlorophetanol 41.5365 µM 0.315098444069293 0.366105444897531 no 1228 0.376343454922764 415 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.314786493739121 0.366234548600084 no 1229 0.376461883619096 389 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1338 1486-1223 76 µM 0.313637315950299 0.366710277636615 no 1230 0.376898257262238 424 3444526 SGTC_938 3126-1755 342 µM 0.313432524397013 0.366795077415516 no 1231 0.376976038639889 420 1777771 SGTC_253 dyclonine 31.25 µM 0.312022818794343 0.367378982396706 no 1232 0.377511590785697 388 3180 An oral anasthetic. SGTC_3126 9127922 49.47 µM 0.311113419299861 0.367755821723282 no 1233 0.377857199957303 439 45595682 SGTC_99 0109-0120 622.8 µM 0.310909018894735 0.367840539234744 no 1234 0.377934893979217 420 759414 SGTC_2680 butyl paraben 22.24 µM 0.310791701523433 0.367889166483896 no 1235 0.377979489362092 417 7184 An antifungal and steroid mimetic. SGTC_1922 5578187 25 µM 0.310356691767477 0.368069493532864 no 1236 0.378144862068315 422 1350412 SGTC_2518 prenyletin 46.28 µM 0.309677034220097 0.368351293999699 no 1237 0.378403284424588 388 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1168 k815-0004 80.5 µM 0.309082721512262 0.368597766739267 no 1238 0.378629301177416 412 642433 SGTC_1322 1348-1070 12 µM 0.308039136457634 0.369030692007303 no 1239 0.379026276347345 407 6758089 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.307830758528482 0.369117156318613 no 1240 0.379105557695694 442 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_38 0929-0051 58.268 µM 0.306330480606039 0.369739876698215 no 1241 0.379676516910791 429 1379719 SGTC_53 0973-0023 39.979 µM 0.304897484650783 0.370334989524618 no 1242 0.380222115783997 417 674768 SGTC_666 0272-0154 136 µM 0.304024739524256 0.370697586476417 no 1243 0.38055452165176 406 6870312 SGTC_2768 sulfasalazine 50.2 µM 0.30317151513072 0.371052184261524 no 1244 0.380879577856367 411 5384001 An antioxidant and salicylic acid derivative. SGTC_1279 0874-0590 65.2 µM 0.302760112296773 0.371223201335901 no 1245 0.381036341651675 417 3523074 SGTC_2552 juarezic acid 87.02 µM 0.302136376731289 0.371482532032047 no 1246 0.381274051424362 383 1549512 SGTC_776 4476-4378 112 µM 0.30098138489259 0.371962897261702 no 1247 0.381714344723521 416 2892008 SGTC_830 4076-0286 57.8 µM 0.300739937343979 0.372063341378601 no 1248 0.38180640606917 402 6866659 SGTC_2107 5363541 170.161 µM 0.300309071344725 0.372242606717859 no 1249 0.381970707232585 434 244052 SGTC_1346 1488-2224 62.4 µM 0.299533416482754 0.372565394065786 no 1250 0.382266539527773 414 3722427 SGTC_3100 9120536 49.47 µM 0.299229194842339 0.372692019798208 no 1251 0.382382587469475 414 16421196 SGTC_246 cycloheximide 667 µM 0.299157018931919 0.372722063492706 no 1252 0.382410121137524 415 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1061 3448-9325 110 µM 0.297880525301643 0.37325354009953 no 1253 0.382897176074171 438 723482 SGTC_3116 9124943 49.47 µM 0.296049662379002 0.374016252982002 no 1254 0.38359607762056 371 41905195 YPL160W CDC60 SGTC_2869 9037858 32.47 µM 0.295784019828847 0.374126957162433 no 1255 0.383697513785558 394 27187042 SGTC_884 0851-0618 334 µM 0.29551025765901 0.37424105598453 no 1256 0.383802058783893 434 9642473 SGTC_1314 1222-0010 41.1 µM 0.294349873784816 0.37472480392648 no 1257 0.38424528296718 403 3526027 SGTC_916 4466-0038 42 nM 0.293846624368926 0.374934662981513 no 1258 0.384437552935794 436 5722064 YGL116W CDC20 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.292250517771875 0.37560049700342 no 1259 0.385047544545914 438 1241132 A phosphatase inhibitor. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.291989374731429 0.375709471129833 no 1260 0.38514737394676 391 94937 An inhibitor of serotonin biosynthesis. SGTC_2379 9035213 200 µM 0.291086071061204 0.376086493177468 no 1261 0.385492746293525 443 646551 SGTC_1274 0865-0114 173 µM 0.289821982262608 0.376614298724338 no 1262 0.385976214936873 389 870624 SGTC_2133 5320837 200 µM 0.289460509285196 0.376765270021279 no 1263 0.386114497994091 416 2841355 SGTC_1031 k035-0009 16 µM 0.288893401219433 0.377002163984019 no 1264 0.386331476799216 434 5180959 SGTC_2565 isoliquiritigenin 100 µM 0.288845267427027 0.377022272699191 no 1265 0.386349894702494 373 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2438 5259590 200 µM 0.287463865640559 0.377599518874575 no 1266 0.386878582940859 443 1201127 SGTC_1547 harmine 94.2 µM 0.28718523012748 0.377715985446518 no 1267 0.386985247429605 412 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2861 9024595 19.48 µM 0.286908993882461 0.377831460126027 no 1268 0.38709100188003 413 16482810 SGTC_713 1488-1073 324 µM 0.285271939907344 0.37851601943015 no 1269 0.387717904385858 446 3312542 SGTC_250 brefeldin a 552.239 µM 0.285005700875608 0.378627387492342 no 1270 0.387819887159325 430 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2811 7967822 32.47 µM 0.284973108676527 0.378641021535621 no 1271 0.387832372122249 396 2232244 SGTC_89 0302-0250 142.109 µM 0.284099023788949 0.379006727020722 no 1272 0.388167247530628 429 4203518 YLR208W SEC13 SGTC_2286 7945697 125 µM 0.280767457941398 0.380401600585931 no 1273 0.389444382407278 416 1245733 SGTC_1786 berberine 21.6 µM 0.280446717428577 0.38053597195826 no 1274 0.389567399550194 449 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_542 3381-0244 89.3 µM 0.280304213746884 0.380595677228393 no 1275 0.389622059108569 461 1112843 SGTC_550 4123-0385 25.7 µM 0.280071495175306 0.380693186263364 no 1276 0.389711326719634 421 5731123 SGTC_2928 9011484 9.79 µM 0.280042190954143 0.380705465263575 no 1277 0.389722567824325 428 2994751 SGTC_3351 9150312 21.596 µM 0.278970259267475 0.381154706581582 no 1278 0.390133824350963 438 4904905 SGTC_693 4161-2696 114 µM 0.278528235706263 0.381340003179597 no 1279 0.390303446629557 426 805759 SGTC_2796 7949634 45.45 µM 0.278253643137806 0.381455126285596 no 1280 0.390408829398068 407 2971588 SGTC_2860 9025725 38.96 µM 0.277477553334775 0.38178055910591 no 1281 0.390706719620441 438 40546248 SGTC_685 1278-0033 54.9 µM 0.276877453253742 0.382032252576329 no 1282 0.39093710286705 449 3590572 SGTC_2629 bisabolol 100 µM 0.275977366337967 0.382409859732079 no 1283 0.391282725219104 450 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_41 0478-0632 82.643 µM 0.275414927516317 0.382645872552892 no 1284 0.391498738445376 454 3750424 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.27502085064028 0.382811262638695 no 1285 0.391650109634228 396 16623 A steroid. SGTC_994 3910-0338 138 µM 0.274433640040106 0.383057748638686 no 1286 0.391875696985964 434 3479481 SGTC_2123 5259487 200 µM 0.272933024081925 0.383687858236474 no 1287 0.392452350181645 434 2173474 SGTC_1928 4'-methoxychalcone 40.3 µM 0.271262155811559 0.384389818880858 no 1288 0.393094705433553 445 641818 SGTC_381 3461-2219 42.7 µM 0.271217073780417 0.384408763886713 no 1289 0.393112040991191 435 2883159 SGTC_1455 4262-0120 131 µM 0.265529443090669 0.386801100657401 no 1290 0.395300815660481 400 1529587 SGTC_1879 gemcitabine 100 µM 0.265299007072164 0.386898118286476 no 1291 0.395389564677835 431 60750 A nucleoside analog which inhibits DNA replication. SGTC_2358 9037157 4 µM 0.264283169272419 0.387325888094589 no 1292 0.395780864171838 421 2388925 SGTC_2862 9027634 71.43 µM 0.263049043519493 0.387845763149642 no 1293 0.396256389242737 404 5012562 SGTC_2923 7992654 58.14 µM 0.262396310454052 0.38812080810162 no 1294 0.396507958445455 436 2985126 SGTC_741 4582-0002 126 µM 0.261888550116147 0.388334804089177 no 1295 0.396703683656368 429 2912688 SGTC_2772 vinpocetine 57.06 µM 0.260831609981227 0.388780360993421 no 1296 0.397111183368065 455 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3169 9102970 49.47 µM 0.260044762238598 0.389112154540887 no 1297 0.397414622847711 423 17027839 SGTC_500 h-89 112 µM 0.259985854823131 0.38913699754682 no 1298 0.397437342367744 437 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1402 3909-7673 35.9 µM 0.259526804084812 0.389330608391079 no 1299 0.397614401813553 420 5328014 SGTC_1372 2752-0194 270 µM 0.259413085048993 0.389378575177466 no 1300 0.397658267393137 426 823334 SGTC_696 1560-0013 611 µM 0.257723644506977 0.390091380790435 no 1301 0.398310098356113 387 1650269 SGTC_572 0960-0087 17.7 µM 0.257561710389202 0.390159723186886 no 1302 0.398372591769368 442 6796365 SGTC_3309 9129340 25.759 µM 0.257189099958342 0.39031699194216 no 1303 0.398516399019815 401 17158987 SGTC_1813 st051246 8.6015 µM 0.256161846521456 0.390750660639822 no 1304 0.398912933988232 431 5291959 SGTC_2137 5261020 140 µM 0.255715229270183 0.390939248475241 no 1305 0.39908536740257 422 763655 SGTC_258 haloperidol 50.781 µM 0.255636128548555 0.390972652085478 no 1306 0.399115909269784 437 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1125 tnp00248 1.32998 µM 0.254207651407404 0.391576024904768 no 1307 0.399667569880678 434 24207736 SGTC_695 3505-6186 243 µM 0.253656570421661 0.391808865199626 no 1308 0.399880444313456 426 1819379 SGTC_2144 5628481 200 µM 0.25353173525549 0.391861615387778 no 1309 0.399928670427789 442 2818399 SGTC_1216 1165-0504 9.65 µM 0.252509659448112 0.392293577119067 no 1310 0.400323574402338 442 6304004 SGTC_1886 st057356 49.9 µM 0.252498247100537 0.392298401090366 no 1311 0.400327984417967 418 24207747 SGTC_3216 9129716 49.47 µM 0.251933717199546 0.392537047137942 no 1312 0.400546148697472 393 8056934 SGTC_574 1315-0397 40 µM 0.250688668015087 0.39306351463322 no 1313 0.401027411295139 435 6794277 SGTC_3253 9135987 49.47 µM 0.248817570098005 0.39385507373649 no 1314 0.401750949737671 429 4182430 SGTC_1910 st062352 60.4 µM 0.248688955357275 0.39390949974556 no 1315 0.401800696421425 425 2245730 SGTC_2383 9036125 200 µM 0.247803088122758 0.394284429172215 no 1316 0.402143382732471 457 79580 SGTC_2081 5214970 32.255 µM 0.24779605144014 0.394287407730538 no 1317 0.402146105083874 422 2063512 SGTC_2981 9013952 38.96 µM 0.246160250946231 0.394979993347269 no 1318 0.402779092043331 379 2996344 SGTC_2831 7999036 19.48 µM 0.24523352760373 0.395372508485526 no 1319 0.403137808775301 463 2988270 SGTC_2813 7971799 71.43 µM 0.24459700678012 0.395642169417839 no 1320 0.403384240959333 437 2234054 SGTC_632 0781-2353 4.65 µM 0.244137580162446 0.395836835754455 no 1321 0.403562134093496 439 6811515 YHR007C ERG11 SGTC_775 4577-0580 57.3 µM 0.244100032483024 0.395852746450311 no 1322 0.403576673694749 437 2006902 SGTC_3314 9135860 59.4275 µM 0.243452213720267 0.396127284654724 no 1323 0.403827549752004 456 25252478 SGTC_140 0062-0056 502.533 µM 0.242800583970989 0.396403489893539 no 1324 0.404079941581443 396 3758964 SGTC_1952 st077036 64.1 µM 0.242794675894535 0.396405994378348 no 1325 0.404082230103976 430 2937007 SGTC_79 0052-0007 94.094 µM 0.242367387420707 0.396587136993228 no 1326 0.404247751099681 458 2801472 SGTC_2532 xanthone 78.9 µM 0.241367353538672 0.397011173724958 no 1327 0.404635206472621 452 7020 An insecticide. SGTC_791 1348-1292 225 µM 0.24050555584494 0.39737669294064 no 1328 0.404969178353057 436 5437054 SGTC_3105 9121040 49.47 µM 0.239678377167686 0.397727613780207 no 1329 0.405289799465253 450 41448907 SGTC_914 3820-6779 408 µM 0.238852147874919 0.398078214486264 no 1330 0.405610116050684 405 2893481 SGTC_1433 4060-0023 7.6 µM 0.23601591530086 0.399282361096715 no 1331 0.4067101601881 432 3840627 SGTC_2188 6126565 140.678 µM 0.235041948455667 0.3996960887504 no 1332 0.407088087452093 444 874518 SGTC_1191 1487-1166 10.6 µM 0.234708805971642 0.399837628950467 no 1333 0.407217376233692 463 3955771 SGTC_719 2810-4230 27.3 µM 0.234013869272601 0.40013292477822 no 1334 0.407487105729763 457 721079 SGTC_1514 1189-1591 158 µM 0.231904756398426 0.401029488129423 no 1335 0.40830599507905 459 767698 YMR146C TIF34 SGTC_2730 imipramine 71.33 µM 0.231768824136973 0.401087289548215 no 1336 0.408358786252198 410 3696 A tricyclic antidepressant. SGTC_1970 st070122 35.8 µM 0.231264708465461 0.401301669630338 no 1337 0.408554581057467 463 102928 SGTC_2423 st077119 87.2 µM 0.23032149647004 0.401702859451623 no 1338 0.408920978909548 409 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3177 9107506 49.47 µM 0.228781050537326 0.402358301940526 no 1339 0.4095195478456 459 8897194 SGTC_589 1227-0070 34.1 µM 0.228512447706932 0.402472617603948 no 1340 0.409623940114248 434 2841384 SGTC_1101 ebselen 5.29 µM 0.227984901202606 0.402697162323094 no 1341 0.409828989272846 458 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_157 1348-1695 65.819 µM 0.227685954489916 0.402824420157175 no 1342 0.409945196183098 439 5380510 SGTC_492 tmb-8 126 µM 0.227605755108013 0.402858561771612 no 1343 0.409976372725216 455 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3153 9100258 49.47 µM 0.227495106022923 0.40290566732065 no 1344 0.410019387156259 463 25236848 SGTC_1073 triclabendazole 3.09 µM 0.226756741563453 0.403220040023942 no 1345 0.410306451361632 417 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1617 st002906 78 µM 0.226185908135866 0.403463126095569 no 1346 0.410528415153752 459 5150859 SGTC_2539 epi(13)torulosol 80 µM 0.225892031538589 0.403588286274189 no 1347 0.410642697784524 429 6708597 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.22497832319386 0.403977491884112 no 1348 0.410998068796198 436 6708514 SGTC_1761 st044296 37 µM 0.219999939428325 0.406099758075188 no 1349 0.412935600938623 420 1826700 SGTC_2052 5265182 7.135 µM 0.216987647935582 0.407385231974107 no 1350 0.414108985570366 465 1239884 SGTC_2266 7929956 200 µM 0.216771053092348 0.407477700902943 no 1351 0.414193385930205 449 2967153 SGTC_1647 st011722 22.4 µM 0.215972889620399 0.407818498271729 no 1352 0.414504439906717 426 2854783 SGTC_1888 azatryptophan 97.5 µM 0.215729804798025 0.407922303747144 no 1353 0.414599183668974 410 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2179 6298986 200 µM 0.215629149287539 0.407965288961644 no 1354 0.414638416210664 462 738374 SGTC_2715 st079500 56.4 µM 0.21542980426585 0.4080504230742 no 1355 0.414716117518441 455 28246688 SGTC_619 1652-1634 108 µM 0.215352748359847 0.408083332439423 no 1356 0.414746153497829 451 5400454 SGTC_639 0833-0042 114 µM 0.212914574159196 0.409124971958079 no 1357 0.415696797239364 462 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1628 st004252 77.7 µM 0.212305357636727 0.409385342665324 no 1358 0.415934407957262 429 692968 SGTC_414 piperonyl butoxide 100 µM 0.21093958487608 0.409969200141056 no 1359 0.416467207376832 456 5794 A potent inhibitor of cytochrome P450. SGTC_951 1171-0579 82.7 µM 0.210242378096129 0.410267327801916 no 1360 0.416739252842315 446 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_812 4251-0442 148 µM 0.210176415107698 0.410295536457295 no 1361 0.416764993230287 470 5723007 SGTC_1683 st010134 710 nM 0.209334422635533 0.410655649945707 no 1362 0.417093590811426 441 3818134 SGTC_3015 9080845 49.47 µM 0.208969492398885 0.410811751124784 no 1363 0.417236027184274 458 5296973 SGTC_2434 5670830 169.91 µM 0.208711747007702 0.41092201183309 no 1364 0.417336634653703 456 1549830 SGTC_832 4083-0019 164 µM 0.206055923247237 0.412058553095842 no 1365 0.418373614020642 438 1990758 SGTC_454 lyso-paf C-16 6.67 µM 0.205154748904244 0.412444372552924 no 1366 0.418725611282095 458 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2740 felodipine 17.08 µM 0.204603526319368 0.412680409020318 no 1367 0.418940950042308 467 3333 L-type calcium channel blocker SGTC_3348 9149464 3.537 µM 0.202178957084244 0.413718996387343 no 1368 0.419888411621037 425 1951442 SGTC_1415 3966-0071 78.1 µM 0.200636081862357 0.414380216584679 no 1369 0.420491571233545 463 2893185 SGTC_430 0958-0115 16.4 µM 0.200158288403132 0.414585030790843 no 1370 0.420678394017325 436 6833180 SGTC_3095 9117207 49.47 µM 0.198079340161348 0.41547647661409 no 1371 0.421491494368062 471 17015229 SGTC_1488 4013-0813 75.9 µM 0.197895003101951 0.415555540781237 no 1372 0.421563606906438 449 2910057 SGTC_3076 9116187 49.47 µM 0.19715566256557 0.415872686292816 no 1373 0.421852862856979 466 27241210 SGTC_2478 5763493 32.33 µM 0.196945885807978 0.41596268155052 no 1374 0.42193494256855 453 1365576 YLR208W SEC13 SGTC_1276 0871-0068 94.2 µM 0.195648609432115 0.41651931719661 no 1375 0.422442605316356 445 3414906 SGTC_1996 st072960 66.8 µM 0.195530155723119 0.416570151700831 no 1376 0.422488966201254 457 1719405 SGTC_2667 digitoxin 100 µM 0.195428725475634 0.416613681681854 no 1377 0.422528665229338 452 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2618 avocadyne 43.43 µM 0.19387799712145 0.417279321970645 no 1378 0.423135706275622 458 3015189 SGTC_714 4296-0578 26.1 µM 0.192375958488835 0.417924288635567 no 1379 0.423723861508349 455 1589775 SGTC_836 0330-0104 1.35 µM 0.190309541542547 0.418811956591304 no 1380 0.424533288608793 426 46494820 SGTC_2064 5220758 200 µM 0.190083537614776 0.418909065962822 no 1381 0.424621834988706 443 788518 SGTC_3197 9113331 49.47 µM 0.190063726463105 0.418917578654437 no 1382 0.424629597007613 427 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1243 0416-0003 5.65 µM 0.189645218002406 0.419097417220194 no 1383 0.424793575652608 456 2141977 SGTC_1851 st056236 18.9 µM 0.188844529380948 0.419441530684476 no 1384 0.42510733515113 457 5393171 SGTC_3300 9124615 50.48 µM 0.186956847552581 0.420253046708031 no 1385 0.425847233491287 441 24824903 SGTC_1149 3909-7961 23.3 µM 0.185630763522825 0.420823334367648 no 1386 0.426367163521205 462 735261 SGTC_851 0394-0702 453 µM 0.185556623912137 0.420855223315907 no 1387 0.42639623591054 451 762646 SGTC_1331 1472-0049 76.2 µM 0.184885163969038 0.421144055462618 no 1388 0.426659553908683 487 24051409 SGTC_1438 4092-1045 4 µM 0.183432016774748 0.421769279756501 no 1389 0.427229528139514 458 1351342 SGTC_2199 6590217 200 µM 0.183327572276413 0.421814225173101 no 1390 0.427270500725384 445 703109 SGTC_1027 k015-0025 8.67 µM 0.182933765283495 0.421983700596085 no 1391 0.42742499452494 425 3598955 SGTC_971 1315-0384 26.7 µM 0.181959265117 0.422403140236766 no 1392 0.427807346946523 467 6769120 SGTC_222 nsc-310342 10.666 µM 0.180704367030326 0.422943396967702 no 1393 0.428299815413445 488 432556 SGTC_2305 7443522 69.23 µM 0.180658528891664 0.422963133880516 no 1394 0.428317806114932 452 5415886 SGTC_1418 3966-3099 2.4 µM 0.180257990439934 0.423135605311239 no 1395 0.428475017081556 478 740335 SGTC_468 gf-109203x 121 µM 0.180226881518197 0.423149001396743 no 1396 0.428487227779516 470 2396 A protein kinase C inhibitor. SGTC_2502 avocadyne acetate 18.59 µM 0.178664960463002 0.423821707816845 no 1397 0.429100391963805 438 3952079 SGTC_1885 st057546 99.9 µM 0.178566059214122 0.42386431125894 no 1398 0.42913922345641 433 702008 SGTC_648 0375-0473 33.3 µM 0.176922238843359 0.42457254556494 no 1399 0.429784735051204 469 1713139 SGTC_232 clozapine 119 µM 0.176501930905371 0.424753672977623 no 1400 0.429949815926563 471 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2417 cerulenin 830 nM 0.175811709054029 0.425051151487088 no 1401 0.430220935215483 493 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2971 9092186 9.93 µM 0.174722773763018 0.425520558106528 no 1402 0.430648736079602 399 25236400 SGTC_3075 9116269 49.47 µM 0.174313137765855 0.425697166992443 no 1403 0.430809687431168 473 17015205 YNL244C SUI1 SGTC_207 4185-0010 4.486 µM 0.174174617249138 0.425756891569005 no 1404 0.430864116559149 460 3761753 SGTC_2748 diazoxide 86.69 µM 0.173058208584965 0.426238304966363 no 1405 0.431302836977286 480 3019 A potassium channel activatior. SGTC_150 3970-0969 77.2 µM 0.17070749484483 0.427252329203567 no 1406 0.432226884651914 452 6615640 SGTC_986 1493-0483 84 µM 0.170538682467942 0.427325168157033 no 1407 0.432293257844491 478 40079 SGTC_1421 4029-0249 71.4 µM 0.167554776444624 0.428613066901759 no 1408 0.433466775634945 467 2894095 SGTC_2602 kawain 100 µM 0.166947775711972 0.428875151095252 no 1409 0.43370557051841 479 5369129 SGTC_3054 9094397 49.47 µM 0.166930667372592 0.428882538403478 no 1410 0.433712301312589 459 2598354 SGTC_2821 7996764 71.43 µM 0.166396498995507 0.429113202557591 no 1411 0.433922464472796 441 2987135 SGTC_107 0358-0022 2.6945 µM 0.165780171209463 0.429379374797165 no 1412 0.434164975631862 490 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_548 1436-0017 110 µM 0.165377320173017 0.42955337062406 no 1413 0.434323501875832 478 9677137 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.165337345220222 0.429570636996104 no 1414 0.434339233028943 463 688662 SGTC_2848 9016370 25.97 µM 0.164350684763021 0.429996847636846 no 1415 0.434727541719664 486 7894410 SGTC_1380 2291-0730 164 µM 0.163796390190731 0.430236323729464 no 1416 0.434945716755185 443 2999191 SGTC_1988 st071872 53.4 µM 0.163480717595959 0.430372717632527 no 1417 0.435069977017863 482 16414116 SGTC_2674 ligustilide 100 µM 0.160998950436876 0.431445312687406 no 1418 0.436047113643823 477 5319022 A signalling regulator. SGTC_964 1287-0107 19.4 µM 0.160389126761072 0.431708950109563 no 1419 0.436287277163662 488 51516812 YPR165W RHO1 SGTC_1013 4112-3890 241 µM 0.159236520620937 0.432207324859989 no 1420 0.436741265819115 471 705171 SGTC_1834 st055981 52.8 µM 0.158129701347816 0.432686003413525 no 1421 0.437177298376435 486 471719 YDL150W RPC53 SGTC_1990 st072050 59.8 µM 0.157637214968689 0.432899026329493 no 1422 0.437371338443189 488 17233948 SGTC_2815 7968870 71.43 µM 0.15726491033443 0.433060078083157 no 1423 0.437518036798089 464 2977326 YHR190W ERG9 SGTC_1266 0828-0227 32.9 µM 0.156306681932184 0.43347464015047 no 1424 0.437895644828794 453 3913820 SGTC_3129 9127257 49.47 µM 0.15628919683028 0.433482205479325 no 1425 0.437902535690494 474 837894 SGTC_2963 9082507 9 µM 0.155979631226001 0.433616150144242 no 1426 0.438024538310936 470 16459611 SGTC_1426 4048-4480 71.7 µM 0.155198424028401 0.43395420132917 no 1427 0.438332445339379 465 14224343 SGTC_2221 6807166 181.081 µM 0.153973156234801 0.434484507729299 no 1428 0.438815450688603 463 674925 SGTC_2586 curcumin 80 µM 0.153616561885029 0.434638867012461 no 1429 0.438956038725948 449 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.153515917393227 0.434682434878581 no 1430 0.438995719412947 469 521171 SGTC_2787 5284540 71.43 µM 0.153393960062277 0.434735229895429 no 1431 0.439043803846324 478 736958 SGTC_655 k060-0012 42 µM 0.153225758908764 0.434808045654035 no 1432 0.439110122427344 482 5994525 SGTC_2076 5212012 200 µM 0.15261851348411 0.435070945923183 no 1433 0.439349562195493 471 604802 SGTC_33 0986-0033 35.816 µM 0.152097898029315 0.435296363553926 no 1434 0.439554861025068 467 2848082 SGTC_2569 tetrandrine 100 µM 0.151433537899907 0.435584050711475 no 1435 0.43981686754751 430 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_955 1216-0110 33 µM 0.149923419801115 0.436238102128746 no 1436 0.440412517108853 468 3619719 SGTC_2274 7947094 46.08 µM 0.149739172085268 0.436317914137634 no 1437 0.44048520086267 461 2971028 SGTC_723 4182-0001 115 µM 0.14944599128111 0.436444918879658 no 1438 0.440600861688261 474 744821 YLR208W SEC13 SGTC_2978 9011784 42.97 µM 0.148494137482267 0.43685730321032 no 1439 0.440976406138448 457 2994934 SGTC_2029 5175081 200 µM 0.146278926821594 0.437817293448356 no 1440 0.441850600433235 456 1380876 SGTC_1225 1216-0074 20.6 µM 0.145758995873267 0.438042665518278 no 1441 0.442055823331758 474 4241466 SGTC_1470 k295-0292 231 µM 0.145702097292291 0.438067330305063 no 1442 0.442078282820196 499 5045612 SGTC_2522 biochanin a 4.94 µM 0.144568401617287 0.438558822506465 no 1443 0.442525823473129 482 5280373 A possible chelator. SGTC_1409 3909-8004 61.9 µM 0.144133660909016 0.438747321253248 no 1444 0.442697462335035 462 2119279 SGTC_2719 novobiocin 32.65 µM 0.143629500831865 0.438965936864384 no 1445 0.442896521946069 466 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2427 5545055 42.75 µM 0.142522972347294 0.439445818706825 no 1446 0.443333467638689 466 5372858 SGTC_2996 9066192 71.4286 µM 0.142439157662712 0.439482171288578 no 1447 0.443366567174729 470 6472854 SGTC_1554 st069299 38.7 µM 0.141927699074607 0.439704015064377 no 1448 0.443568557542691 461 24207999 SGTC_2816 7982706 58.44 µM 0.141403307764409 0.439931488031803 no 1449 0.44377567065472 471 2981853 SGTC_1076 itraconazole 331 nM 0.141217152814986 0.440012243988182 no 1450 0.443849197939815 461 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_209 4077-0173 175.592 µM 0.140175791070185 0.440464043499091 no 1451 0.44426054948071 483 15993494 SGTC_2208 7283366 200 µM 0.138819750886635 0.441052483787026 no 1452 0.444796293075969 485 898663 SGTC_2006 4011487 200 µM 0.138152576729448 0.441342045300904 no 1453 0.445059916947151 462 45595294 SGTC_1063 disulfiram 1.84 µM 0.13767490669064 0.441549379046055 no 1454 0.445248676039082 475 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_828 2074-0507 139 µM 0.137391697073258 0.441672314379158 no 1455 0.445360596794491 500 X828 SGTC_1045 1348-1485 165 µM 0.137352093614951 0.441689505854804 no 1456 0.445376247913136 461 6810614 SGTC_2114 5491910 81.25 µM 0.136664678654597 0.441987923468774 no 1457 0.445647924930996 513 2849228 SGTC_453 enantio-paf c16 10 µM 0.1360390409005 0.442259551254828 no 1458 0.445895208831662 497 13871343 A lipid and platelet activating factor SGTC_1971 st069429 63.5 µM 0.135337615627006 0.442564115334689 no 1459 0.44617247284124 504 1246522 YGL099W LSG1 SGTC_6 0844-0013 19.835 µM 0.135092932688918 0.442670366485124 no 1460 0.446269198926574 493 1584900 SGTC_1933 st074711 15.9 µM 0.134918400638062 0.442746157825352 no 1461 0.446338195483094 504 17250958 SGTC_2693 st077581 40.7 µM 0.133499984666508 0.443362188905859 no 1462 0.446898988198358 494 25238761 SGTC_1074 carmofur 3.8 µM 0.133422730495657 0.443395745046626 no 1463 0.446929534890579 485 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1948 st076329 66.6 µM 0.133331919778757 0.443435190131093 no 1464 0.446965442312656 497 24208413 SGTC_1826 st055655 41.6 µM 0.132970986211377 0.443591972924813 no 1465 0.44710816317689 498 676168 SGTC_1841 st054148 70 µM 0.13266721816671 0.443723930928294 no 1466 0.44722828487806 480 675442 SGTC_659 k018-0002 107 µM 0.132605414212123 0.443750779567595 no 1467 0.447252725158844 480 6797879 YHR007C ERG11 SGTC_54 0159-0055 9 µM 0.131360225539774 0.444291764540315 no 1468 0.447745175690593 485 3319099 SGTC_1771 st048882 4.1505 µM 0.130904559788155 0.444489759190486 no 1469 0.447925403768087 469 4580403 SGTC_2411 st077133 39.94 µM 0.130355548918372 0.444728332304432 no 1470 0.448142566630366 498 1403142 YNL221C POP1 SGTC_2528 xanthyletin 44.79 µM 0.130205653103326 0.444793473134645 no 1471 0.448201861064064 485 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1965 Pectolinarigenin 58.4 µM 0.130019741614687 0.444874267512856 no 1472 0.448275403860507 470 5320438 An anti-inflammatory. SGTC_1734 st037168 69.4 µM 0.127790326667257 0.445843315668722 no 1473 0.449157452749217 454 708907 SGTC_1898 st060199 18.6 µM 0.127686230291211 0.445888570649478 no 1474 0.44919864376196 469 688866 SGTC_681 1642-0006 26.6 µM 0.127661970488504 0.445899117485905 no 1475 0.449208243462457 496 4446530 SGTC_2327 6189656 200 µM 0.12759741294302 0.445927183765092 no 1476 0.44923378928499 498 5349088 SGTC_2239 6685329 187.64 µM 0.12754225158644 0.445951165282372 no 1477 0.449255617143817 425 805680 SGTC_1998 st075797 76.8 µM 0.127536114696582 0.445953833320535 no 1478 0.44925804557737 501 24208315 SGTC_2366 9070441 60.58 µM 0.12712210835556 0.446133829929136 no 1479 0.449421876739552 462 6837235 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.126579745995374 0.44636964838765 no 1480 0.449636514165827 497 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1321 1326-2144 215 µM 0.126368290823986 0.446461593968952 no 1481 0.449720200579843 509 3513030 SGTC_2355 9061122 103.12 µM 0.125629769415353 0.446782742646732 no 1482 0.450012498529487 493 5302957 SGTC_3223 9129970 49.47 µM 0.125239446073453 0.446952490260762 no 1483 0.45016699480936 476 17248386 SGTC_3087 9117406 49.47 µM 0.124984873971737 0.447063206292646 no 1484 0.450267762627588 450 42546093 SGTC_2110 5483698 200 µM 0.124903838955282 0.447098450122918 no 1485 0.450299839564113 485 2848765 YHR062C RPP1 SGTC_405 ebelactone b 50 µM 0.123555252271976 0.447685039907996 no 1486 0.450833712212301 491 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2011 4012611 177 µM 0.123229864384432 0.447826589864366 no 1487 0.45096253871664 493 2049887 SGTC_215 1287-0124 461.5 µM 0.12299735542929 0.447927739779362 no 1488 0.45105459606413 490 5560863 SGTC_3152 9099253 49.47 µM 0.122878287672515 0.447979539927788 no 1489 0.451101739620056 494 25236131 SGTC_1166 k206-0078 225 µM 0.122722278160258 0.448047412842831 no 1490 0.451163510897642 465 5404595 SGTC_1008 4106-0037 6 µM 0.122704783486898 0.448055024104886 no 1491 0.451170437910094 515 2905394 SGTC_1917 st066507 28.5 µM 0.122219549041166 0.448266138631291 no 1492 0.451362572311306 478 3156428 SGTC_2741 miltefosine 3.04 µM 0.121828757901931 0.448436173667417 no 1493 0.45151731903814 504 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1696 st025591 34.7925 µM 0.121659759278501 0.448509708687763 no 1494 0.451584241937629 471 2787147 SGTC_1471 k673-0312 37 µM 0.121539028615159 0.448562242339891 no 1495 0.451632051726262 483 24099884 SGTC_2297 7971671 152.32 µM 0.121200202854404 0.448709680740681 no 1496 0.451766231724023 481 909016 SGTC_1668 st014914 51.6 µM 0.120154945095566 0.449164564175421 no 1497 0.452180203863935 503 2839556 SGTC_1138 3761-0006 1.03 µM 0.118422139956534 0.449918806777586 no 1498 0.452866592029873 502 12061087 SGTC_2827 7993847 71.43 µM 0.117304332150142 0.450405454075415 no 1499 0.453309446087512 500 2985692 SGTC_3267 9137951 49.47 µM 0.115470324745464 0.451204066287655 no 1500 0.454036170269632 501 16643986 SGTC_1608 st001473 40.5 µM 0.11545190664718 0.451212087392476 no 1501 0.454043469213161 506 7292267 SGTC_1387 3342-1166 1.8 µM 0.112860452736562 0.452340865892898 no 1502 0.455070595045477 486 3418228 SGTC_700 3453-2283 142 µM 0.111900328772001 0.452759172410351 no 1503 0.455451217959722 483 565664 SGTC_858 0438-0351 2.77 µM 0.111342370716143 0.453002287525967 no 1504 0.455672428646666 500 2799119 SGTC_25 0118-0223 35.662 µM 0.110256185810691 0.45347561363837 no 1505 0.456103102002233 496 5333628 SGTC_3068 9116768 49.47 µM 0.108899149315778 0.454067061377722 no 1506 0.456641240690414 504 41904888 SGTC_1323 1348-1351 11.2 µM 0.108572161791979 0.454209590166324 no 1507 0.456770920934241 508 6989654 SGTC_3330 9141424 71.43 µM 0.108218846513401 0.454363601442191 no 1508 0.456911047697917 471 27261020 SGTC_2439 5492030 7.2 µM 0.107847470471997 0.454525492859333 no 1509 0.457058343233903 496 5722370 SGTC_3027 9089541 49.47 µM 0.107158737903594 0.454825747311842 no 1510 0.457331524632887 498 9943819 SGTC_1819 st053448 58.6 µM 0.104636764762242 0.455925425973011 no 1511 0.458332020381358 507 2857616 SGTC_523 1934-0222 13.7 µM 0.104237268228078 0.456099653247075 no 1512 0.45849052963984 513 1361595 SGTC_56 0957-0365 83.25 µM 0.103878784017222 0.456256001532271 no 1513 0.458632771954126 510 6752360 SGTC_419 nsc-638432 893 µM 0.103406723368972 0.45646189505041 no 1514 0.458820088138922 462 368090 SGTC_1126 isoteolin 1.0172 µM 0.100295289728708 0.45781926485279 no 1515 0.460054948445237 475 133323 SGTC_1776 st049249 45.9 µM 0.0991840686210855 0.458304157603539 no 1516 0.460496061940256 507 1822314 SGTC_1923 st058458 19.1 µM 0.0971115214999567 0.459208700097142 no 1517 0.461318915637976 511 3534982 SGTC_367 0335-0881 7.1 µM 0.0966182265421892 0.45942402504942 no 1518 0.461514790763516 510 23828853 SGTC_2350 9023895 38.85 µM 0.0965691183694605 0.459445461588881 no 1519 0.461534290905944 511 2997209 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0960659460552938 0.459665111509223 no 1520 0.461734098646537 494 77254 SGTC_3260 9137109 49.47 µM 0.0955286734330269 0.459899660834337 no 1521 0.461947458146184 509 17478346 SGTC_752 1896-0090 130 µM 0.0946645885609208 0.460276911085629 no 1522 0.462290622928575 500 772567 SGTC_1548 st061468 90.8 µM 0.0943427935295579 0.460417412525339 no 1523 0.462418428582708 513 390799 SGTC_186 3455-3465 67.277 µM 0.0939981733851032 0.46056788529579 no 1524 0.462555303870314 504 755278 SGTC_1310 1188-0297 994 nM 0.0937974987428148 0.46065550921113 no 1525 0.462635009320307 500 1588352 SGTC_3283 9109332 35.8195 µM 0.0928807904436653 0.461055811075581 no 1526 0.462999133387079 513 17027281 SGTC_2369 9071472 200 µM 0.0924545735129243 0.461241942012945 no 1527 0.463168440830392 505 17296037 SGTC_2711 st079103 59.1 µM 0.0921989223706109 0.46135359014501 no 1528 0.463269997111622 511 54693780 SGTC_2097 5376186 200 µM 0.0910868285970828 0.46183929978734 no 1529 0.463711799195317 480 742755 SGTC_1351 1496-0003 46.5 µM 0.0894411876480752 0.462558141667934 no 1530 0.4643656458044 505 3891978 SGTC_1638 st008370 60.6 µM 0.0883687591835225 0.463026661275716 no 1531 0.464791795345861 506 24207134 SGTC_1677 st019204 53.9 µM 0.0880519912996419 0.463165059802558 no 1532 0.464917676747349 479 3945625 SGTC_268 camptothecin 39.6153 µM 0.0878129575086162 0.46326949860929 no 1533 0.465012669474408 512 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2537 larixol 68.93 µM 0.0871906736964576 0.463541399132489 no 1534 0.465259976218545 523 6708759 SGTC_2485 5633444 17.78 µM 0.0871797424015974 0.463546175602143 no 1535 0.465264320631321 507 5724239 SGTC_2253 7938677 135.83 µM 0.086852395341725 0.463689213540494 no 1536 0.465394419737793 492 2301972 SGTC_2576 guaiol 23.12 µM 0.0867295705134212 0.463742884427216 no 1537 0.465443235551365 487 227829 SGTC_2898 9056270 58.44 µM 0.0853741316529443 0.464335215492158 no 1538 0.465981979006671 499 19154699 SGTC_2713 st079149 53.4 µM 0.0849891141108789 0.464503483848635 no 1539 0.466135022538592 510 3103253 SGTC_1300 1094-0077 113 µM 0.0847817713474787 0.464594103718052 no 1540 0.46621744285637 495 5532636 SGTC_350 k064-0020 19.8 µM 0.0826060631066963 0.465545114356452 no 1541 0.467082390046774 498 2790705 SGTC_1183 1254-0324 198 µM 0.0812227209607832 0.46614988134652 no 1542 0.4676324152487 502 5799357 SGTC_750 4073-0104 132 µM 0.0807799632376481 0.466343461939355 no 1543 0.467808471502888 509 22330957 SGTC_1864 st057645 30.4 µM 0.0804388428543564 0.46649261053255 no 1544 0.467944117423968 512 688666 SGTC_687 k029-0044 34.9 µM 0.0801517456591553 0.466618142131259 no 1545 0.468058284004425 511 5829338 SGTC_2872 9044037 25.97 µM 0.0797471691067625 0.466795046537965 no 1546 0.468219171682956 508 6465195 SGTC_1478 0453-0656 35.7 µM 0.0793129983482292 0.466984898549462 no 1547 0.468391833842711 511 5258496 SGTC_2243 6634756 200 µM 0.0787806926411977 0.467217672764686 no 1548 0.468603530674984 449 885676 SGTC_104 0074-0074 590.992 µM 0.0774841614464716 0.467784685129805 no 1549 0.469119195362841 493 3943124 SGTC_902 1120-0002 2.07 µM 0.0764921155088626 0.46821858107319 no 1550 0.469513793255681 501 3280475 SGTC_1914 st062367 72.6 µM 0.076373712141366 0.468270370260541 no 1551 0.469560891589961 498 978205 SGTC_2112 5488546 200 µM 0.0759668784888669 0.468448321856077 no 1552 0.469722724581763 519 600757 SGTC_2727 riluzole 51.77 µM 0.0757122036343952 0.468559721448105 no 1553 0.469824033383688 511 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0756319667695162 0.468594819078821 no 1554 0.469855951744089 495 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1802 st050112 57.9 µM 0.0754994384539717 0.468652790844839 no 1555 0.469908672155991 513 4662563 SGTC_2511 berberine 10.47 µM 0.0753316613083081 0.468726182434538 no 1556 0.46997541548137 509 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_477 mead ethanolamide 10 µM 0.0746296555981622 0.46903327577512 no 1557 0.470254689078143 499 16061185 SGTC_1481 3346-2004 36 µM 0.0743205970198255 0.46916847971714 no 1558 0.470377644150524 517 2770522 SGTC_1989 st071868 50.2 µM 0.0731553707632691 0.469678263414519 no 1559 0.470841240076754 517 16414057 SGTC_449 xestospongin c 11.1929 µM 0.0731027108666415 0.469701303173448 no 1560 0.470862192236455 514 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2299 7976368 114.88 µM 0.071478391107196 0.470412025033205 no 1561 0.471508510979968 506 2979718 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0709335023680609 0.470650462578858 no 1562 0.471725339744069 515 5355888 SGTC_1646 st011709 75.6 µM 0.0707808628035302 0.470717257927266 no 1563 0.471786081444256 524 5757843 SGTC_114 0364-0001 490.298 µM 0.0702418533558462 0.470953136011202 no 1564 0.472000581206053 468 4003655 SGTC_1379 2144-0755 36.5 µM 0.0701213736464826 0.471005861015943 no 1565 0.472048527431921 524 5392327 SGTC_1468 k284-1086 134 µM 0.0700268222873609 0.471047239466911 no 1566 0.472086155469261 495 15996457 SGTC_147 4466-0538 29.23 µM 0.0695363652457864 0.471261882875001 no 1567 0.472281343707197 482 6742687 YHR072W ERG7 SGTC_85 0868-0259 160.055 µM 0.069494179569441 0.471280345386992 no 1568 0.472298132742629 510 83173 SGTC_2905 7799065 20.05 µM 0.0692946413751975 0.47136767388046 no 1569 0.472377545524886 522 1296806 SGTC_724 3910-0327 137 µM 0.0688014769576967 0.471583514674871 no 1570 0.472573821216734 521 2885483 SGTC_876 0720-0963 56.8 µM 0.0687100391164551 0.471623534734851 no 1571 0.472610213516234 520 765861 SGTC_184 1494-0393 24.714 µM 0.0686336684031747 0.471656960508748 no 1572 0.472640609267676 508 3090647 SGTC_767 0929-0023 86 µM 0.068011850230228 0.471929123994373 no 1573 0.472888100504496 524 1204563 SGTC_2183 6420625 130.508 µM 0.0678892084680947 0.471982804597109 no 1574 0.472936914664352 493 2897619 SGTC_2037 5169046 200 µM 0.067647929017893 0.472088414694116 no 1575 0.473032950458825 502 5718022 SGTC_2244 6635614 200 µM 0.0672946576464687 0.472243048159407 no 1576 0.473173564915174 525 836499 SGTC_1642 st009582 77.7 µM 0.0657476952271182 0.472920231415655 no 1577 0.473789349616587 515 6739311 SGTC_1581 himbacine 57.9 µM 0.062647793912636 0.474277447748329 no 1578 0.475023485048501 501 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1090 efavirenz 20.7 µM 0.0618972050773833 0.474606120300025 no 1579 0.475322346628626 496 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2773 thioridazine 9.09 µM 0.0614595071926498 0.474797790190168 no 1580 0.475496630996013 526 5452 An antipsychotic. SGTC_3134 9127454 49.47 µM 0.0602340665685302 0.475334447086622 no 1581 0.475984606881762 524 24262820 SGTC_278 4092-0821 23.9 µM 0.0601868321453679 0.47535513334732 no 1582 0.476003416563976 514 877900 SGTC_2074 5212007 75.395 µM 0.0580902884648423 0.476273378317618 no 1583 0.476838355006831 536 758611 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0576150593070748 0.476481537052111 no 1584 0.477027627003552 521 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_645 0845-0943 5.41 µM 0.0566467106087338 0.476905710625478 no 1585 0.477413312286138 515 1885106 SGTC_1420 4'-methoxyflavone 42 µM 0.0564714653827519 0.476982477512504 no 1586 0.477483113282532 523 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3156 9099931 49.47 µM 0.055531078377576 0.477394432400644 no 1587 0.477857685588253 515 18111053 SGTC_1962 st076595 64.5 µM 0.0539698149142646 0.478078427477046 no 1588 0.478479606693747 513 279619 SGTC_3269 9137823 49.47 µM 0.0532397235164497 0.478398305397235 no 1589 0.478770452845083 527 17682936 SGTC_2918 7977171 22.06 µM 0.0525860190318814 0.478684727421767 no 1590 0.479030878376891 524 2236483 SGTC_2259 7964009 200 µM 0.0524148302583259 0.478759735975632 no 1591 0.479099078761538 501 313134 SGTC_2988 9073640 71.4286 µM 0.0521920070979455 0.478857369923939 no 1592 0.479187850833449 526 9102229 SGTC_188 3229-0966 278.469 µM 0.0495841095170615 0.480000159604577 no 1593 0.480226904911639 528 5722370 SGTC_2480 5767542 37.17 µM 0.0494573187657745 0.480055724014232 no 1594 0.480277425119684 521 2867358 SGTC_2924 9010168 62.78 µM 0.0485146212168892 0.480468861123006 no 1595 0.480653056058451 520 2993929 SGTC_1394 3474-0001 65.7 µM 0.0483951802048372 0.480521207641603 no 1596 0.480700650222704 515 5017666 YIL048W NEO1 SGTC_2043 5101342 149 µM 0.0482251013458102 0.48059574740996 no 1597 0.480768422738218 525 678451 SGTC_784 4579-0127 173 µM 0.0460658886657623 0.48154211485252 no 1598 0.481628867016385 529 1948547 SGTC_2900 5328528 85.29 µM 0.0458083825083081 0.481654985003071 no 1599 0.481731488775365 530 795359 SGTC_1579 chlormadinone acetate 49.4 µM 0.0449680051405895 0.482023349562483 no 1600 0.482066405672099 534 45114258 A steroidal progestin. SGTC_1169 aniline yellow 25.8 µM 0.043825458336918 0.482524189308702 no 1601 0.482521766879105 532 6051 A DNA damaging agent. SGTC_1527 coumarin 137 µM 0.0434786538620453 0.482676217864673 no 1602 0.482659990091413 531 323 A hepatotoxic, DNA x-linker. SGTC_195 4234-0266 16.654 µM 0.0433894879103459 0.482715305919601 no 1603 0.482695528621644 535 2303354 SGTC_1902 st060212 70.5 µM 0.0422206621511386 0.483227704228276 no 1604 0.483161395615263 517 688944 SGTC_2616 abietic acid 100 µM 0.0422173591826619 0.48322915224719 no 1605 0.483162712135204 535 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1094 duloxetine 25.4 µM 0.0414409647058272 0.483569529101949 no 1606 0.483472177859252 521 60834 A selective serotonin reuptake inhibitor. SGTC_926 2268-1401 59.4 µM 0.040625661240954 0.483926976818714 no 1607 0.483797163164353 532 2931578 SGTC_1801 st050089 28.441 µM 0.0405029514946588 0.483980776708107 no 1608 0.483846077010817 510 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_106 0092-0003 11.579 µM 0.0403962202706664 0.484027571337907 no 1609 0.483888621789222 525 1072148 SGTC_2116 5511452 16.8835 µM 0.0394394466713429 0.484447063453002 no 1610 0.484270015232618 525 870744 SGTC_818 4072-2707 53.5 µM 0.0387583685977414 0.484745688899098 no 1611 0.484541518461027 525 882871 SGTC_1570 verbenone 133 µM 0.037673930341168 0.485221189212485 no 1612 0.484973830905039 527 29025 A natural terpanoid with antifungal properties. SGTC_369 0957-0393 4.5 µM 0.037595836207827 0.485255432446789 no 1613 0.485004963900717 522 6997992 SGTC_2926 9010726 65.15 µM 0.0375280768588627 0.485285144104303 no 1614 0.48503197690685 517 2994293 SGTC_1345 1488-0192 31.4 µM 0.0371403127790724 0.485455175544274 no 1615 0.485186564619151 527 658348 SGTC_2096 5468907 200 µM 0.0370396920825798 0.485499297346313 no 1616 0.485226678867807 536 759785 SGTC_282 k297-0036 65.7 µM 0.0369745255527923 0.485527872722563 no 1617 0.485252658755642 531 5061378 SGTC_1233 0325-0408 14.2 µM 0.0352965006291421 0.486263708042465 no 1618 0.485921656843608 527 12874 SGTC_3159 9100096 49.47 µM 0.0342358063393013 0.486728860294708 no 1619 0.486344556968741 527 25236875 SGTC_2536 dehydroabietamide 32.04 µM 0.0330462728778254 0.487250534564167 no 1620 0.486818843676812 536 3983547 SGTC_3322 9139058 2.11 µM 0.0328740135199449 0.487326081367869 no 1621 0.486887527899371 501 4908926 YPR165W RHO1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0328090252173179 0.487354583035242 no 1622 0.486913440503029 533 688664 SGTC_1650 st011916 45.8 µM 0.0325333148750846 0.487475500965263 no 1623 0.487023374327706 535 242528 SGTC_3005 9076496 71.4286 µM 0.0314538245281689 0.487948942632711 no 1624 0.487453808297473 534 21368410 SGTC_2582 agaric acid 100 µM 0.0313777143810193 0.487982323584525 no 1625 0.487484156873164 527 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2640 pentamidine 10.38 µM 0.0312774586087213 0.488026294631831 no 1626 0.487524133517864 534 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1892 st058411 7.36 µM 0.0312569824649582 0.488035275254708 no 1627 0.487532298325258 537 3934738 SGTC_974 1326-0144 138 µM 0.0308767812449549 0.488202028637683 no 1628 0.487683903487461 522 5411856 SGTC_603 3794-0023 45.9 µM 0.0306796000793369 0.488288511621424 no 1629 0.487762530140979 529 3802260 SGTC_407 eburnamonine 100 µM 0.0306351440289484 0.488308009969047 no 1630 0.487780257206531 532 3195 SGTC_1559 coumarin 343 70.1 µM 0.029932545442872 0.488616172186948 no 1631 0.488060424980938 526 108770 A hepatotoxic, DNA x-linker. SGTC_301 4119-0100 24.5 µM 0.0283155508828239 0.489325417220545 no 1632 0.488705238881046 533 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1845 st056753 3.01 µM 0.0280984357856061 0.489420650713836 no 1633 0.488791820822228 534 5375839 SGTC_3213 9129884 49.47 µM 0.0275734110985636 0.489650945495566 no 1634 0.489001194234721 525 17190742 SGTC_2080 5212524 12.4 µM 0.027236274267905 0.489798827704441 no 1635 0.489135641873838 538 260183 SGTC_1313 1220-0047 237 µM 0.026767802349559 0.490004321258472 no 1636 0.48932246700708 530 3528706 SGTC_1291 0993-0025 5.79 µM 0.0267549800245459 0.49000994576365 no 1637 0.489327580543247 532 4353356 SGTC_1048 3161-0300 24.5 µM 0.026028816249958 0.490328480276002 no 1638 0.489617177094827 533 2165101 SGTC_3020 9089140 49.47 µM 0.0257389716810507 0.490455623436573 no 1639 0.489732769619111 537 17217859 SGTC_3165 9101544 49.47 µM 0.0249754528548957 0.490790553060486 no 1640 0.490037271642009 534 5002184 SGTC_328 k915-0120 63.5 µM 0.0247709712482053 0.490880253267554 no 1641 0.490118822769547 531 6624543 SGTC_2947 9072639 7.68 µM 0.0242708473008824 0.491099645211362 no 1642 0.490318283381144 525 16488146 SGTC_921 1561-0023 372 µM 0.0239893092871073 0.491223150128434 no 1643 0.49043056810376 536 24050882 SGTC_340 k038-0059 454 µM 0.0239114236199182 0.491257317112544 no 1644 0.490461631078981 527 23733424 SGTC_212 3807-4682 38.772 µM 0.0233299473778506 0.491512401864303 no 1645 0.490693541828931 525 3125501 YBL034C STU1 SGTC_920 mycophenolic acid 780.421 nM 0.0230942619970918 0.491615794437828 no 1646 0.490787541364999 542 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_77 0828-0286 12.516 µM 0.0230024379396619 0.491656076790547 no 1647 0.490824164135069 510 745345 SGTC_171 k064-0041 9.68 µM 0.0225365746207397 0.491860447961377 no 1648 0.491009968536767 537 53325 SGTC_790 1575-0012 79.1 µM 0.0220114176195945 0.49209083343943 no 1649 0.491219423900882 534 378741 YLR208W SEC13 SGTC_1307 1187-1599 12.2 µM 0.0216089469289552 0.492267398432812 no 1650 0.491379948290931 541 1538471 SGTC_216 k038-0035 28.382 µM 0.0214931032268001 0.492318219664284 no 1651 0.491426152510669 533 4444231 YPR107C YTH1 SGTC_392 N-ethylmaleimide 8.33 µM 0.0211782124022277 0.492456364525916 no 1652 0.491551747184535 536 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1726 st035556 14.5795 µM 0.0181217561458466 0.493797298305779 no 1653 0.492770860952985 509 5919439 SGTC_1232 0279-0259 161 µM 0.0180218611920356 0.49384112565814 no 1654 0.492810706766484 536 1560000 SGTC_1843 st055809 45.5 µM 0.0165657566511596 0.494479976974328 no 1655 0.4933915215209 535 16413835 SGTC_2649 anisomycin 9.56 µM 0.0157579812437564 0.494834386572341 no 1656 0.493713735190401 543 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_144 4161-2749 112.381 µM 0.0154958060948185 0.494949416204557 no 1657 0.493818315171898 541 797501 YMR168C CEP3 SGTC_2425 5628681 7.85 µM 0.0154444273058107 0.494971958753719 no 1658 0.493838809890556 539 5714958 SGTC_1946 st076057 65.1 µM 0.0146544651235965 0.495318558260826 no 1659 0.494153923510361 542 953009 SGTC_936 3005-4620 401 µM 0.0132119083711888 0.495951495542373 no 1660 0.494729364481934 541 777207 SGTC_1486 3970-0793 4.53 µM 0.0131393158648136 0.495983346567519 no 1661 0.49475832218837 535 2844330 SGTC_2960 9079389 5.97 µM 0.0125930759712804 0.49622301812648 no 1662 0.494976222338201 544 16457355 SGTC_364 0083-0097 67.7 µM 0.0125541584998579 0.496240093847483 no 1663 0.494991746935761 538 5207356 SGTC_475 α-linolenic acid 10 µM 0.0123261475639013 0.496340137769473 no 1664 0.495082703099968 534 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_10 0279-0212 42.575 µM 0.0116478908053563 0.496637736525547 no 1665 0.495353268953418 536 39851 YBR002C RER2 SGTC_3175 9106517 49.47 µM 0.0111329536167928 0.496863676803119 no 1666 0.495558685841415 537 41468073 SGTC_2408 sulbentine 18.36 µM 0.0110644002158019 0.496893756227716 no 1667 0.495586033007158 534 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2553 4-methylesculetin 85.09 µM 0.0101426072631238 0.497298216313866 no 1668 0.495953754503905 528 5319502 SGTC_3011 9081274 71.4286 µM 0.0100197276078235 0.497352133104572 no 1669 0.496002773902792 543 6625322 SGTC_2356 9061756 188.97 µM 0.00988740581971759 0.497410192941899 no 1670 0.496055560043729 536 20104043 SGTC_1327 1436-0082 2.18 µM 0.00965480054358652 0.497512255060175 no 1671 0.496148351693091 538 15992205 SGTC_1459 k035-0031 35.7 µM 0.00946288681453466 0.49759646273862 no 1672 0.496224910695947 539 3877128 YMR208W ERG12 SGTC_2689 tacrolimus 100 µM 0.00910613785358869 0.497752996906344 no 1673 0.496367226805092 543 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.00869605946551737 0.497932931364873 no 1674 0.496530817930472 544 4330530 SGTC_1951 sophoraflavanone G 9.2 µM 0.00547875147571716 0.499344635524295 no 1675 0.497814305327093 538 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_948 3448-0295 75.3 µM 0.00487125142105528 0.499611198453965 no 1676 0.498056659535295 544 678569 SGTC_1056 3448-1962 115 µM 0.00462912404430265 0.499717440775814 no 1677 0.498153253293098 544 715507 SGTC_538 2922-0838 53.3 µM 0.00406124449559702 0.499966618949795 no 1678 0.498379802313504 543 777039 SGTC_864 0469-0573 172 µM 0.00390909301579122 0.499966618949795 no 1679 0.498440501489765 538 689425 SGTC_2303 7774051 200 µM 0.00387648070801576 0.499952309091224 no 1680 0.498453511819619 547 2953184 SGTC_861 0443-0273 110 µM 0.00328363873416997 0.499692177734952 no 1681 0.498690020029472 540 6149169 SGTC_1596 piperlongumine 63 µM 0.00226091018571837 0.499243418105054 no 1682 0.499098028103164 542 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1304 1165-0502 251 µM 0.00203927623498467 0.499146168193759 no 1683 0.499186447052327 547 767425 SGTC_1748 st037455 53.6035 µM 0.00160343243379848 0.498954926117086 no 1684 0.499360323282492 546 580690 SGTC_1718 roemerine 11.9335 µM 0.00131876757715082 0.498830019343419 no 1685 0.49947388800795 546 235224 An aporphine alkaloid with mutagenic activity. SGTC_3218 9131285 49.47 µM 0.0012154076186698 0.498784666533816 no 1686 0.499515122632369 547 17156417 SGTC_1732 st034308 51.822 µM 0.000968880169576961 0.498676494027191 no 1687 0.499613472796187 546 830119 SGTC_2627 acetyl isogambogic acid 100 µM 0.000451438758041388 0.498449448907582 no 1688 0.499819901998523 547 6857789 A caspase activator and apoptosis inducer. SGTC_1217 1183-1422 255 µM 4.78126965586539e-05 0.498272344511055 no 1689 0.49998092549381 547 2849664 SGTC_1503 4585-0012 61.3 µM 1.59003716557487e-05 0.498258341928207 no 1690 0.499993656669473 548 2922052 SGTC_599 1935-0052 86.5 µM -0.00247081983717995 0.497167219551811 no 1691 0.49901428650265 550 9557311 SGTC_192 3455-0609 60.9 µM -0.00247675325649872 0.497164616109888 no 1692 0.499011919418059 550 3769639 SGTC_2691 st077356 60.2 µM -0.00264862744245266 0.497089201897026 no 1693 0.498943351763612 553 2839272 SGTC_2465 5809242 33.21 µM -0.00326855362187526 0.496817194249599 no 1694 0.498696038086276 549 2731748 SGTC_359 0081-0058 15.9 µM -0.00368306250118828 0.496635319242624 no 1695 0.498530673968805 550 3494159 SGTC_1452 4194-0072 190 µM -0.00405503450399374 0.496472108832305 no 1696 0.498382279721316 554 1343545 SGTC_2643 anethole 100 µM -0.00465647716805602 0.496208214683999 no 1697 0.498142341093142 551 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2162 5663267 200 µM -0.00484236706491511 0.496126652366765 no 1698 0.498068182590294 555 6456493 SGTC_1629 st005085 44.9 µM -0.00603617897741063 0.495602851326677 no 1699 0.497591927617052 550 24207091 SGTC_2395 5646831 180.19 µM -0.0062949179656835 0.495489327082543 no 1700 0.49748870765725 553 6808628 SGTC_1262 0737-0114 49.6 µM -0.0102224966629591 0.493766113975337 no 1701 0.495921884896796 551 765919 SGTC_1555 citronellol 128 µM -0.0103139946094923 0.493725970793663 no 1702 0.495885384421666 554 8842 A terpine precursor. SGTC_906 1165-0455 526 µM -0.010472893657943 0.493656256665911 no 1703 0.495821996296791 560 3252859 SGTC_286 k060-0067 22.9 µM -0.0106563860021704 0.493575752908793 no 1704 0.495748797527682 557 5985051 SGTC_142 0335-0849 62.6745 µM -0.0116712498180189 0.493130505631547 no 1705 0.495343950689048 554 3889043 YPR107C YTH1 SGTC_399 oxolinic acid 75 µM -0.0122206179581255 0.492889487006873 no 1706 0.495124800150744 555 4628 A DNA gyrase inhibitor. SGTC_2089 5281248 129.67 µM -0.0128356194727223 0.492619676811597 no 1707 0.494879469301481 555 2737878 SGTC_1413 3910-0535 34.4 µM -0.0128953710440924 0.492593463097813 no 1708 0.49485563384606 556 2876951 SGTC_3004 9076122 71.4286 µM -0.012965582007386 0.492562660767241 no 1709 0.49482762606577 556 44782551 SGTC_1205 4161-2785 76 µM -0.0132738609244855 0.492427415904533 no 1710 0.494704651156181 570 3498106 SGTC_3160 9100216 49.47 µM -0.0134374879996191 0.49235563151913 no 1711 0.494639379219434 558 17191039 SGTC_2022 5136654 200 µM -0.0141849092850745 0.492027735559985 no 1712 0.49434122971158 556 1713771 SGTC_2304 7443016 91.4 µM -0.014328251556494 0.491964851484496 no 1713 0.494284050230154 557 939854 SGTC_27 0485-0001 32.618 µM -0.0147781024836519 0.491767503748436 no 1714 0.494104604680783 555 2054479 SGTC_3240 9133527 49.47 µM -0.0163348455166969 0.491084582894501 no 1715 0.493483629271655 561 17617455 SGTC_1186 1319-0216 26 µM -0.0166165027813873 0.490961026623267 no 1716 0.493371279530141 555 4565136 SGTC_417 st075190 100 µM -0.0168012343637156 0.490879989789109 no 1717 0.493297592578441 561 222757 SGTC_3137 9097352 49.47 µM -0.0168695962901196 0.490850001324618 no 1718 0.493270323980293 553 44120435 SGTC_2316 5844804 197.44 µM -0.0188968137974503 0.489960741964513 no 1719 0.492461710654746 561 776813 SGTC_1202 1988-0068 29.6 µM -0.0189792393387637 0.489924586197145 no 1720 0.492428833517543 558 2850480 SGTC_337 1315-0038 354 µM -0.0196752873702591 0.489619269716936 no 1721 0.492151202392632 560 1626437 SGTC_225 nsc-122657 1.016 µM -0.0209850908383823 0.489044750448661 no 1722 0.491628774422748 561 275685 SGTC_1132 3456-3614 2.5 µM -0.0234148159611707 0.487979060888967 no 1723 0.490659693409197 573 3125502 SGTC_617 3770-0098 35 µM -0.0236814553700522 0.487862116602655 no 1724 0.490553349164499 555 5962639 SGTC_94 0334-0113 514.748 µM -0.023709503961828 0.487849814946152 no 1725 0.490542162536286 557 6795178 SGTC_387 norethindrone acetate 66.7 µM -0.0242886512734263 0.487595812948404 no 1726 0.490311182716989 569 541197 SGTC_98 0074-0023 107.663 µM -0.0245698691056653 0.487472478448779 no 1727 0.490199026505852 573 3563821 SGTC_2508 celastrol 40.54 µM -0.0248706423935198 0.487340568783985 no 1728 0.490079071982131 557 122724 Celastrol is a natural product and antioxidant. SGTC_1993 st073995 70.8 µM -0.0250249355335365 0.487272901222333 no 1729 0.490017537077465 559 3098394 SGTC_2551 apiole 73.87 µM -0.0253732019628903 0.487120165126645 no 1730 0.489878642980048 558 10659 A possible DNA adduct former. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0258924822757581 0.48689243251553 no 1731 0.489671548156428 556 368090 SGTC_3008 9078912 71.4286 µM -0.0263598945792979 0.486687450495677 no 1732 0.489485141257318 561 16648731 SGTC_2726 cimetidine 79.27 µM -0.026786912345761 0.486500186430782 no 1733 0.489314845954357 557 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3242 9133940 49.47 µM -0.0275471140098333 0.486166815531872 no 1734 0.489011681271701 566 17248444 SGTC_2341 7987486 176.74 µM -0.0277259639648127 0.486088385936439 no 1735 0.488940357705804 559 1258686 SGTC_590 k048-0076 22.4 µM -0.0280551694663932 0.485944023572467 no 1736 0.48880907478423 564 6832814 SGTC_922 1866-0035 480 µM -0.0283249370938269 0.485825727127102 no 1737 0.488701495825958 573 3156169 SGTC_110 0850-0284 111.64 µM -0.0286320253809582 0.485691066628994 no 1738 0.488579034994286 560 3906265 SGTC_3312 9133330 71.43 µM -0.0288750419750692 0.485584503200638 no 1739 0.488482125469311 566 17617324 SGTC_2219 9098279 200 µM -0.0291336702008364 0.485471095160864 no 1740 0.488378991125581 556 902349 SGTC_2262 9014885 67.46 µM -0.029422875521855 0.485344280508667 no 1741 0.488263664336363 570 6457424 SGTC_2636 apigenin dimethyl ether 100 µM -0.0317477511726994 0.484324892599875 no 1742 0.487336607065816 576 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0324900512060116 0.483999437663275 no 1743 0.487040624915075 573 689007 SGTC_3229 9132204 49.47 µM -0.0331659976333987 0.483703084150459 no 1744 0.486771106577318 558 17682924 SGTC_1114 scopoletin 1.73284 µM -0.034011582074888 0.483332369359154 no 1745 0.486433957442624 557 5280460 A coumarin with genotoxic properties. SGTC_1697 st025554 27.742 µM -0.034119431626714 0.483285087796586 no 1746 0.48639095665406 565 1269519 SGTC_80 0159-0065 512.242 µM -0.0359136580687691 0.48249852860797 no 1747 0.485675602664727 565 1548079 SGTC_563 tetrahydrosecaminediol 614 µM -0.0360088858814072 0.482456784186887 no 1748 0.485637636820912 564 334274 A psychoactive constituent of the cannabis plant. SGTC_2890 9046729 58.44 µM -0.0361588585119483 0.482391042012255 no 1749 0.485577845336042 570 903329 SGTC_22 0964-0034 14.468 µM -0.0367825646735095 0.482117638619133 no 1750 0.485329188007827 554 138402 SGTC_3243 9134147 49.47 µM -0.0368798812071371 0.482074980391393 no 1751 0.485290390651985 565 24282180 SGTC_743 1275-0778 158 µM -0.03994955773082 0.480729510544547 no 1752 0.484066670628936 576 2849257 YMR203W TOM40 SGTC_49 0717-0965 32.132 µM -0.0404268190058656 0.480520341495213 no 1753 0.483876424623632 592 5889349 YGL099W LSG1 SGTC_698 k064-0052 127 µM -0.0407239643984918 0.480390114444925 no 1754 0.483757978306447 558 5088751 SGTC_737 1950-0117 57.9 µM -0.0408091816529811 0.480352767484846 no 1755 0.483724009778729 574 5393513 SGTC_2589 lobaric acid 100 µM -0.040854896485195 0.480332732763369 no 1756 0.483705787396335 562 73157 A novel microtubule depolymerizer. SGTC_3203 9113543 49.47 µM -0.0417762455412796 0.479928958243635 no 1757 0.483338535894457 573 17018012 SGTC_840 0245-0196 390 µM -0.0420728233112186 0.479798989555561 no 1758 0.483220322418637 567 3827528 SGTC_2700 st077718 96.8 µM -0.0428792725795539 0.479445591791484 no 1759 0.482898885818345 577 904970 SGTC_2722 naftopidil 47.16 µM -0.0430177404933503 0.479384914761221 no 1760 0.4828436960374 573 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3337 9144342 33.5465 µM -0.0434052834159067 0.479215094903908 no 1761 0.482689233057749 565 17682949 SGTC_1689 st020265 53.493 µM -0.0463733126647093 0.477914642963504 no 1762 0.481506353515413 563 5758320 YPR016C TIF6 SGTC_813 k007-0158 173 µM -0.0464715510564246 0.477871603427373 no 1763 0.481467204274283 567 6523916 SGTC_91 0417-1751 58.384 µM -0.0465321880242198 0.47784503770017 no 1764 0.481443039765163 564 6795624 SGTC_2654 protoveratrine a 100 µM -0.0475276233420426 0.477408940621627 no 1765 0.481046357481828 572 5702278 A heart drug and vasodilator. SGTC_433 pimozide 108 µM -0.0477067413065448 0.477330472461937 no 1766 0.480974980718286 579 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2571 chrysanthemic acid 100 µM -0.0485430589613357 0.476964109349428 no 1767 0.480641724391003 590 2743 An insecticide. SGTC_2255 7941087 197.44 µM -0.0488357869685599 0.476835879472394 no 1768 0.480525081155376 565 935561 SGTC_2351 9026858 72.31 µM -0.0493670560992295 0.476603162487765 no 1769 0.480313390780651 582 1409300 SGTC_1999 st074831 12.5 µM -0.0495395891333638 0.476527587877349 no 1770 0.480244644174492 601 17112523 SGTC_707 0865-0008 204 µM -0.0502142139298479 0.476232090242759 no 1771 0.479975842382707 569 723043 SGTC_2712 st079126 47.7 µM -0.0503940296502386 0.47615332996523 no 1772 0.479904196996123 585 3152970 SGTC_3294 9122953 26.2835 µM -0.0512146280984938 0.475793915191239 no 1773 0.479577247802412 562 16459826 SGTC_2621 lithochol-11-enic acid 100 µM -0.0519926751776574 0.475453155720211 no 1774 0.479267264941485 580 6708711 SGTC_1123 mangostin 811.285 nM -0.0524395429486633 0.475257450182029 no 1775 0.47908923336438 570 5281650 An antioxidant. SGTC_2005 4024620 188 µM -0.0528296128285191 0.475086624132505 no 1776 0.478933833407063 573 236743 SGTC_2120 5538279 151.968 µM -0.0548062843141082 0.474221037527062 no 1777 0.478146396885513 572 2058197 SGTC_1295 1013-0063 9.78 µM -0.0550823941903952 0.47410013830267 no 1778 0.478036411124464 581 6826038 SGTC_2493 resveratrol 26.09 µM -0.0559538485167087 0.473718573472492 no 1779 0.477689286536092 569 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1727 st034309 9.9045 µM -0.0564817441848746 0.473487446934221 no 1780 0.47747901916829 630 870305 SGTC_2475 5812728 15.03 µM -0.0569405560142374 0.473286574354943 no 1781 0.477296273837431 575 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_291 SEC14.278 35.5 µM -0.0581106863241995 0.47277431003598 no 1782 0.476830231161579 573 1068044 SGTC_2204 7233102 200 µM -0.0581827760393801 0.472742751776427 no 1783 0.476801520103918 587 2172480 SGTC_1450 4112-4260 37.6 µM -0.0585895023741191 0.472564704967807 no 1784 0.476639536105952 573 1633175 SGTC_269 exalamide 29 µM -0.0586549550704493 0.472536053182042 no 1785 0.476613469087039 581 3316 A derivative of salicylamide. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.0589359696431672 0.472413041236454 no 1786 0.47650155410003 574 5282362 SGTC_2109 5483026 200 µM -0.0593274879950956 0.472241661509395 no 1787 0.476345633707918 570 759335 SGTC_975 1335-0046 28.5 µM -0.0604517549725356 0.471749563656081 no 1788 0.475897919742884 586 16486740 SGTC_1451 4152-0210 104 µM -0.0606645677344831 0.471656419168435 no 1789 0.475813175268368 591 659563 SGTC_824 1304-0008 100 µM -0.0609452462577632 0.471533573375151 no 1790 0.475701407545556 575 768245 SGTC_2387 9077560 195.08 µM -0.0611193692224425 0.471457365578358 no 1791 0.47563207178923 567 5303272 SGTC_2328 6201408 200 µM -0.061262779623922 0.47139460042778 no 1792 0.475574966328168 581 2890418 SGTC_395 anisomycin 6.25 µM -0.0625395720733393 0.470835829571953 no 1793 0.475066574820904 596 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3132 9126706 49.47 µM -0.0633613330226804 0.470476227363202 no 1794 0.474739388565902 574 850858 SGTC_1529 apigenin 74 µM -0.0641502098449135 0.470131037878121 no 1795 0.474425311235237 576 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1212 0520-0165 585 µM -0.0641814626528491 0.470117363021547 no 1796 0.474412868809471 603 5403258 SGTC_276 colchicine 750 µM -0.0642571728762517 0.470084235698033 no 1797 0.474382727018624 574 2833 A microtubule depolymerizer. SGTC_1007 4101-0031 70 µM -0.0643574957694712 0.470040339317351 no 1798 0.474342786645657 616 1146276 SGTC_2009 4012297 12.05 µM -0.0650729869801442 0.469727286023071 no 1799 0.474057944050766 598 45595307 SGTC_1744 st037937 38.9 µM -0.0667778599055832 0.468981418199427 no 1800 0.473379274647106 590 1016152 SGTC_2318 6029776 164 µM -0.0667926376969786 0.468974953509812 no 1801 0.473373392294385 581 818325 SGTC_422 cantharidin 155 µM -0.0668152487010366 0.468965062120413 no 1802 0.473364391914586 569 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1388 3346-4487 254 µM -0.0672104860538316 0.468792165044592 no 1803 0.473207068669333 588 3345614 SGTC_1924 st058459 75.1 µM -0.0676565396427178 0.468597045413352 no 1804 0.473029523168556 600 688683 SGTC_2028 5153890 36.43 µM -0.0678428666688466 0.468515541606465 no 1805 0.472955359841083 595 2830968 YPR165W RHO1 SGTC_139 0099-0334 718.624 µM -0.0688768248633712 0.46806328813825 no 1806 0.472543832890444 581 97690 SGTC_2151 5563267 85.4165 µM -0.0700996375517344 0.467528482926268 no 1807 0.472057177593119 581 5310824 SGTC_2744 captopril 92.04 µM -0.070900747055082 0.467178144104701 no 1808 0.471738374404868 581 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_607 4491-0986 66.8 µM -0.0715239292514908 0.466905633490494 no 1809 0.471490390268399 582 698981 YDR232W HEM1 SGTC_452 diindolylmethane 8 µM -0.0726348369134253 0.466419884533404 no 1810 0.471048352038853 586 3071 Inhibits expression of several cancer promoting factors. SGTC_336 4111-0029 111 µM -0.0727738481875631 0.466359104786472 no 1811 0.470993040942596 604 3131175 SGTC_3193 9111931 49.47 µM -0.0739700628874357 0.465836117716238 no 1812 0.470517103168543 588 17087244 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0745732797607847 0.46557241260791 no 1813 0.47027711728561 583 2374 Ca(2+)-ATPase inhibitor. SGTC_640 3381-0960 37.1 µM -0.0754090650263353 0.465207061821169 no 1814 0.46994462344994 594 1745025 SGTC_1389 3405-0187 19 µM -0.0767002724350682 0.464642687948059 no 1815 0.469430993904557 587 799890 SGTC_957 1187-1561 14.1 µM -0.0767477852915508 0.464621921902457 no 1816 0.469412094724921 572 1538454 SGTC_1706 st031321 9.9705 µM -0.0770244096913865 0.464501021912075 no 1817 0.469302063261455 582 6103185 SGTC_2842 9000675 19.48 µM -0.0794772782478134 0.463429128864465 no 1818 0.468326501882737 569 2989072 SGTC_1174 0739-0097 51.1 µM -0.0795625910486851 0.463391852267788 no 1819 0.468292574437917 598 728447 SGTC_168 3970-0862 530.542 µM -0.0808314351524382 0.462837481322815 no 1820 0.467788004110568 575 3135186 SGTC_1423 4048-0112 5.59 µM -0.0814233497445341 0.462578892414482 no 1821 0.467552640174633 587 X1423 SGTC_382 3229-0966 23.2 µM -0.0815497138523192 0.462523689946369 no 1822 0.467502395280991 593 5722370 SGTC_3205 9113483 49.47 µM -0.0828931036843437 0.461936871662711 no 1823 0.466968268816375 603 17018033 SGTC_585 0kpi-0023 191 µM -0.083085549039772 0.461852814617854 no 1824 0.466891758154913 582 64601 SGTC_2093 5331342 194.4 µM -0.08329258498326 0.461762386540779 no 1825 0.466809448067184 589 33839 SGTC_1686 st019653 115.5 µM -0.0838623302702018 0.46151354639135 no 1826 0.46658294505275 589 97252 SGTC_2059 5238311 157 µM -0.0840067575924733 0.461450469160749 no 1827 0.466525529490664 581 703021 SGTC_2933 9026794 32.47 µM -0.0840337020043793 0.461438701557765 no 1828 0.466514818100328 587 17586027 SGTC_856 0433-0016 11.3 µM -0.0840544771490485 0.46142962832083 no 1829 0.466506559236172 591 3911780 SGTC_2278 7948257 134.34 µM -0.0844137562790882 0.461272721658255 no 1830 0.466363735197237 573 1247028 SGTC_3287 9117173 37.0625 µM -0.0855740796039202 0.460766019185824 no 1831 0.465902502168032 586 2789709 SGTC_674 0498-0004 451 µM -0.088126964221947 0.45965142344784 no 1832 0.464887882700574 588 4231473 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0886547576210146 0.459421026804215 no 1833 0.464678144539521 637 61125 An anti-inflammatory. SGTC_151 3013-0144 2.285 µM -0.0891235970600057 0.459216376646854 no 1834 0.464491842136339 606 906558 YHR107C CDC12 SGTC_2205 7238770 200 µM -0.0895122886401409 0.459046719519083 no 1835 0.464337393932621 605 279867 SGTC_985 1493-0307 8.71 µM -0.0897656872214011 0.458936119451167 no 1836 0.464236707852488 601 3278274 SGTC_5 0352-0601 109.883 µM -0.0899942806284994 0.458836348744981 no 1837 0.464145879892328 602 762456 SGTC_937 3122-0005 46.7 µM -0.0905809436093496 0.458580308709874 no 1838 0.463912787235612 578 759535 SGTC_3336 9143619 71.43 µM -0.0908166071146357 0.458477461829228 no 1839 0.463819157006393 593 45595730 SGTC_1805 st050013 60.3 µM -0.0922513871009582 0.457851363814925 no 1840 0.463249155534993 589 4037144 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.0929983961790567 0.457525431162622 no 1841 0.462952417682865 585 6708784 An antioxidant flavonoid SGTC_3115 9123671 49.47 µM -0.0931729351104783 0.457449280993516 no 1842 0.46288308774516 582 3286988 SGTC_1764 st044502 93.5 µM -0.0939918064821916 0.457092033790362 no 1843 0.462557832701186 589 8407 SGTC_822 1487-0950 154 µM -0.0941044713870999 0.457042884428235 no 1844 0.462513084246595 586 1958375 SGTC_484 loperamide 105 µM -0.0949095038099789 0.456691713220243 no 1845 0.462193353825025 580 3955 An opioid-receptor agonist. SGTC_2394 5221648 200 µM -0.095217566637713 0.4565573389995 no 1846 0.462071008610842 606 788586 SGTC_2742 clothiapine 36.27 µM -0.0956429317620778 0.456371806745735 no 1847 0.461902083428419 590 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3042 9091578 49.47 µM -0.09686627999718 0.455838269948963 no 1848 0.461416293752793 572 25236497 SGTC_1487 3970-0795 2.82 µM -0.0968704669562358 0.455836444033774 no 1849 0.461414631216317 591 3765103 SGTC_559 1550-0661 158 µM -0.097075924864937 0.455746845852801 no 1850 0.461333049860452 607 5830875 SGTC_871 0574-0004 149 µM -0.0973817821952045 0.455613468638014 no 1851 0.461211605831422 585 9551173 SGTC_3047 9092122 49.47 µM -0.0973876758350709 0.455610898608846 no 1852 0.461209265732144 606 17173831 SGTC_26 0302-0163 425.158 µM -0.098683847237543 0.455045724741073 no 1853 0.460694647146767 601 3100915 SGTC_1614 st002383 48.6 µM -0.0991037728405954 0.454862642660039 no 1854 0.460527938271935 595 1947235 SGTC_1708 st033234 31.827 µM -0.0994505446980866 0.454711461883091 no 1855 0.460390276385946 592 674664 SGTC_1827 berberine 7.24 µM -0.0996796480386496 0.454611584188693 no 1856 0.460299329284835 581 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2994 9053520 71.4286 µM -0.100124068302186 0.454417847181966 no 1857 0.460122913799996 619 4647384 SGTC_1675 st018485 24.5 µM -0.100753741003921 0.45414337128903 no 1858 0.459872974615316 587 3323024 SGTC_1344 1488-0097 29.1 µM -0.102253800042281 0.453489580294343 no 1859 0.459277612622694 582 747966 SGTC_598 3937-0236 20.2 µM -0.102273112699699 0.453481163815946 no 1860 0.459269948168784 584 1379313 SGTC_622 1348-1566 26.3 µM -0.102710439659337 0.453290581822906 no 1861 0.459096393909599 599 7340407 SGTC_2049 5262831 67.185 µM -0.103272182581238 0.453045796592736 no 1862 0.458873476317813 605 763417 SGTC_481 bay k-8644 50 µM -0.103531981382494 0.452932592632993 no 1863 0.458770384197668 640 2303 A calcium channel antagonist. SGTC_237 nikkomycin 200 µM -0.104565881739249 0.452482121947394 no 1864 0.458360144336322 609 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_631 k072-0230 41.5 µM -0.105126209769991 0.452238012378147 no 1865 0.458137831071809 617 5773147 SGTC_1144 3486-0183 12.5 µM -0.105180133279332 0.452214521295918 no 1866 0.458116437309029 639 6744069 SGTC_1012 4112-3522 18 µM -0.107083489781832 0.451385456311457 no 1867 0.45736137254655 610 3112398 SGTC_1226 3909-7979 35.4 µM -0.107469165641787 0.451217489140842 no 1868 0.457208392938612 588 6615510 SGTC_2072 5231554 129 µM -0.108611959600207 0.450719837964924 no 1869 0.456755137243268 598 789545 SGTC_3006 9075424 71.4286 µM -0.108875860474484 0.45060492833434 no 1870 0.45665047667806 592 7465181 SGTC_1265 0819-1001 68.8 µM -0.110026227670244 0.450104075599458 no 1871 0.45619428725813 611 3106768 SGTC_2459 5811157 9.22 µM -0.110271942339507 0.449997105365962 no 1872 0.45609685415356 585 2870684 YBR192W RIM2 SGTC_2315 7733312 200 µM -0.11091770327374 0.449715995013565 no 1873 0.455840803521435 607 726316 SGTC_829 1635-0120 117 µM -0.111433291264084 0.449491569192287 no 1874 0.455636380917605 592 285054 SGTC_1241 0364-0022 50.8 µM -0.111730139442071 0.449362364049253 no 1875 0.455518690564822 618 4563895 SGTC_1051 3253-3903 78 µM -0.112098125674828 0.449202203049406 no 1876 0.455372801777442 584 5509239 SGTC_581 0958-0271 211 µM -0.11325261062712 0.448699783017627 no 1877 0.454915143339401 603 4591145 SGTC_716 1683-5115 658 µM -0.1139671914287 0.448388845931805 no 1878 0.454631900698044 604 723597 SGTC_2695 st077686 51.995 µM -0.114753179894269 0.448046873695365 no 1879 0.454320380420414 606 2876092 SGTC_2010 4012422 159 µM -0.115084984047309 0.447902522071989 no 1880 0.454188880906 610 952393 SGTC_357 1325-0123 420 µM -0.115136418314377 0.447880146176106 no 1881 0.454168497098112 640 1098503 SGTC_3051 9093778 49.47 µM -0.117854424255405 0.446697946125063 no 1882 0.453091502833198 607 17217378 SGTC_2062 5245942 200 µM -0.118423077766968 0.446450669126439 no 1883 0.452866220511863 600 1376160 SGTC_2967 9089538 49.85 µM -0.118477944824817 0.446426811477356 no 1884 0.452844484740917 597 728216 SGTC_1416 3966-0321 25.3 µM -0.119261214190229 0.446086246410062 no 1885 0.452534205364124 610 582530 YLR208W SEC13 SGTC_3335 9143315 29.6265 µM -0.1213765544076 0.44516669713983 no 1886 0.451696393219791 600 4899691 SGTC_3035 9091303 49.47 µM -0.121988621757015 0.444900683116847 no 1887 0.451454014745017 597 25237002 SGTC_1767 st044992 70.3 µM -0.122443442752936 0.444703026875534 no 1888 0.45127391749101 604 9600693 SGTC_2495 cafestol 54.53 µM -0.122856107249659 0.444523702913107 no 1889 0.451110521788382 643 16667697 An anti-infammatory. SGTC_2368 9071271 200 µM -0.123442775432083 0.444268784948122 no 1890 0.450878243088507 631 27209959 SGTC_1868 st057644 42.7 µM -0.124196418196568 0.443941347341897 no 1891 0.450579879074133 607 688665 SGTC_2323 6148992 148.28 µM -0.12469498101822 0.443724756157584 no 1892 0.450382515477978 607 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1816 st051957 91.6 µM -0.125320373048498 0.443453090198028 no 1893 0.450134961984817 596 674121 SGTC_394 menadione 8.33 µM -0.126478151317386 0.442950229582104 no 1894 0.449676721436055 613 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2953 9074162 66.49 µM -0.126500039597969 0.442940723675028 no 1895 0.449668058851881 591 16451992 SGTC_3093 9117344 49.47 µM -0.127026764742734 0.442711981029574 no 1896 0.449459607468481 597 24824913 SGTC_1985 st071382 65.5 µM -0.129999455269794 0.441421381185602 no 1897 0.448283428832774 637 6123237 SGTC_2914 7968218 45.32 µM -0.130141015385007 0.441359937964597 no 1898 0.448227430226511 618 2977111 SGTC_1425 4048-4433 7.33 µM -0.130305976383171 0.441288339527491 no 1899 0.448162175958288 616 23734946 SGTC_3029 9088683 49.47 µM -0.131438882352675 0.440796673458409 no 1900 0.447714065893336 614 25236615 SGTC_1540 guanosine 70.6 µM -0.132085117608894 0.440516256803753 no 1901 0.447458483599138 600 6802 Guanosine is a purine nucleoside SGTC_2337 9009472 200 µM -0.132557990297906 0.440311085129109 no 1902 0.447271479010137 596 5742383 SGTC_42 0133-0086 60.653 µM -0.1326099212183 0.440288554133309 no 1903 0.447250942863265 614 162923 Model of phenazepam hydroxylation. SGTC_2442 5158906 48.48 µM -0.132712544899831 0.440244029903991 no 1904 0.447210360617067 593 1893835 SGTC_3113 9123498 49.47 µM -0.135615710003696 0.438984780112241 no 1905 0.446062542704758 593 8897275 SGTC_961 1252-1571 372 µM -0.136923153846271 0.438417876307205 no 1906 0.445545768538855 628 6813498 SGTC_1631 benzylvanillin 81.9 µM -0.136960176457508 0.438401825245744 no 1907 0.445531136496623 619 75506 SGTC_742 0kpi-0133 140 µM -0.137358155910403 0.438229288643131 no 1908 0.445373852114183 627 2728852 SGTC_1563 conessine 56.1 µM -0.137965345544995 0.437966075481981 no 1909 0.445133902915682 593 441082 An anti-amoebic, histamine inhibitor. SGTC_1040 k898-0338 155 µM -0.13863986322011 0.437673708189749 no 1910 0.444867370592741 593 20969351 SGTC_2549 cedrol 20.94 µM -0.138933372663678 0.437546498177585 no 1911 0.444751399563144 609 6708665 A sedative which affects the nervous system. SGTC_3299 9121982 43.1275 µM -0.139057863191388 0.437492544651101 no 1912 0.444702212472409 625 17594604 YPL160W CDC60 SGTC_2135 5326629 150.42 µM -0.142065814573031 0.436189270293147 no 1913 0.443514010134055 612 5020077 SGTC_3034 9090421 49.47 µM -0.142428785097357 0.436032050274276 no 1914 0.443370663466518 609 17173761 SGTC_2157 5649910 96.377 µM -0.142617539263677 0.435950295745429 no 1915 0.44329612237774 639 2858091 SGTC_1483 3453-0561 55.9 µM -0.142742860482072 0.435896017251531 no 1916 0.443246632763474 612 4546991 SGTC_1794 st048918 76.9 µM -0.145659687623001 0.434633038983737 no 1917 0.442095023244158 611 672303 SGTC_2614 arthonioic acid 13.39 µM -0.146000767499824 0.434485395615568 no 1918 0.441960391271523 629 6710684 SGTC_2526 patulin 37.61 µM -0.146333084057931 0.434341554415836 no 1919 0.441829224827719 616 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_245 methotrexate 289.6 µM -0.147015913101256 0.434046023319638 no 1920 0.441559729980831 604 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2396 5342950 42.78 µM -0.14702354999935 0.434042718248228 no 1921 0.441556716048711 593 1886677 SGTC_2661 dactinomycin 12.96 µM -0.148008731557334 0.433616393388697 no 1922 0.441167938677859 604 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2550 chrysin dimethyl ether 71.87 µM -0.148536233386798 0.433388155354862 no 1923 0.440959796493576 610 88881 An O-methylated flavonoid and antioxidant. SGTC_1504 k297-0033 30 µM -0.148765606091715 0.433288917931795 no 1924 0.440869295472828 616 4388117 SGTC_777 1315-0167 517 µM -0.15245915528042 0.431691498228269 no 1925 0.439412401575022 607 4221767 SGTC_1359 1582-0056 520 nM -0.152821065216606 0.431535035763573 no 1926 0.439269692610161 634 3661189 SGTC_2997 9067075 71.4286 µM -0.153071349649915 0.431426837998917 no 1927 0.439171004626057 633 27209819 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.15406554295951 0.430997099896586 no 1928 0.438779028295421 608 279621 SGTC_2430 5571206 200 µM -0.154143456914489 0.430963425187779 no 1929 0.43874831202656 614 1731771 SGTC_626 0214-0009 33 µM -0.154356369614566 0.430871406066338 no 1930 0.438664376650513 638 3437874 SGTC_1759 st043059 70 µM -0.154560704240393 0.430783097847152 no 1931 0.438583825554354 646 669426 SGTC_1822 st052468 42 µM -0.154793822907177 0.430682354125492 no 1932 0.438491930559946 618 2873678 SGTC_3209 9113616 49.47 µM -0.155551548515079 0.430354929354969 no 1933 0.438193259304768 639 16649353 SGTC_774 k060-0086 136 µM -0.156187875916187 0.430079999575356 no 1934 0.437942466535107 653 5911235 SGTC_2298 7976326 193.81 µM -0.1565320610353 0.429931306063847 no 1935 0.437806824829499 618 2235818 SGTC_952 1185-0122 232 µM -0.157009445912981 0.429725084567493 no 1936 0.437618701837826 604 678600 SGTC_2474 5321570 43.32 µM -0.158146458022993 0.42923399354078 no 1937 0.437170696497223 624 2841384 SGTC_2954 9074818 52.69 µM -0.15872581346728 0.428983804095829 no 1938 0.436942449895439 642 16648742 SGTC_247 mechlorethamine 29.705 µM -0.158808642974502 0.428948037245776 no 1939 0.436909819562452 613 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_620 0109-0052 432 µM -0.159014125324972 0.428859309834883 no 1940 0.436828872515826 621 493037 SGTC_2047 4141938 200 µM -0.159989412549357 0.428438229284504 no 1941 0.436444707173937 614 3807862 SGTC_1443 4112-3303 14 µM -0.160266705625759 0.42831852276754 no 1942 0.43633549244327 612 704433 SGTC_1370 2001-0092 44.6 µM -0.160678642730655 0.428140703042408 no 1943 0.436173255740018 606 790957 SGTC_67 0335-0847 266 µM -0.160937010906732 0.428029181425834 no 1944 0.436071505875558 681 4552207 YOR254C SEC63 SGTC_52 0329-0193 875 nM -0.162681318057519 0.427276422390211 no 1945 0.435384678527329 603 3739292 SGTC_2753 fluvastatin 17.09 µM -0.165350043388739 0.426125242138118 no 1946 0.434334235967791 627 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_280 3448-3607 3.04 µM -0.166214509631465 0.425752480784552 no 1947 0.433994070621864 613 626179 SGTC_219 mitoxanthrone 164.414 µM -0.166670940698051 0.425555692596053 no 1948 0.433814485816001 622 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1476 4112-3294 3.34 µM -0.168015166187234 0.424976243758044 no 1949 0.433285673897767 607 704369 SGTC_2150 5556613 200 µM -0.169680921796875 0.424258419432011 no 1950 0.432630539342405 615 743190 SGTC_61 0978-8327 98.565 µM -0.170092372319715 0.424081151585223 no 1951 0.432468746057666 652 6150059 YHR072W ERG7 SGTC_1282 0886-0010 32.4 µM -0.170597349200896 0.42386361017845 no 1952 0.432270191200777 622 2836211 YNL267W PIK1 SGTC_3144 9087057 49.47 µM -0.171564841396651 0.423446884445059 no 1953 0.431889825022103 701 17249618 SGTC_760 0568-0725 82.9 µM -0.171649386933403 0.423410472397561 no 1954 0.431856589233962 643 3916171 SGTC_489 paxilline 115 µM -0.17203451331241 0.423244614559665 no 1955 0.431705197889334 666 105008 A toxic potassium channel blocker. SGTC_1976 st070609 63.5 µM -0.172210006233301 0.423169041601238 no 1956 0.431636215783537 606 682556 SGTC_3162 9099653 49.47 µM -0.173033612850636 0.422814407618342 no 1957 0.431312503436203 617 25237511 SGTC_404 fumagillin 50 µM -0.174514773014255 0.422176797441447 no 1958 0.430730460861719 622 12015870 A methionine aminopeptidase binder. SGTC_2160 5660466 132.927 µM -0.174580825561388 0.42214836786248 no 1959 0.43070450808534 696 2859134 SGTC_1089 terbinafine 2.25 µM -0.175158408143247 0.421899788696623 no 1960 0.43047758226239 633 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_874 0599-0792 117 µM -0.175686055836177 0.421672727628815 no 1961 0.430270295369735 645 765305 SGTC_464 bw-b 70c 158 µM -0.17578920200905 0.421628344082293 no 1962 0.430229776542117 657 5353454 SGTC_2462 5162487 171.77 µM -0.176413474098027 0.421359742592762 no 1963 0.429984559936678 656 2259986 SGTC_2656 pseudo-anisatin 100 µM -0.176462649522714 0.421338585755887 no 1964 0.429965244776822 615 6708809 A neurotoxin. SGTC_656 4090-1979 187 µM -0.177252647143823 0.420998734742137 no 1965 0.429654971929843 630 22330961 SGTC_3099 9120367 49.47 µM -0.177363045138554 0.42095124703979 no 1966 0.429611616393827 618 24824940 SGTC_2134 5324836 1.464 µM -0.177838152632278 0.420746892663941 no 1967 0.429425041720461 602 699272 SGTC_781 4335-2806 94.4 µM -0.177853600747715 0.42074024844161 no 1968 0.429418975511196 663 845254 SGTC_201 4262-0159 12.803 µM -0.178229993057808 0.420578369385641 no 1969 0.429271177877574 642 1341029 SGTC_536 3852-0578 10.6 µM -0.178961009869186 0.420264011582888 no 1970 0.428984158501499 633 2869208 SGTC_963 1269-2853 151 µM -0.179782150162306 0.419910958801173 no 1971 0.42866179869494 609 3668223 SGTC_1221 2958-7315 257 µM -0.181240974564844 0.419283890127321 no 1972 0.428089217039099 644 4562705 SGTC_551 k048-0028 34.9 µM -0.181321829578682 0.419249140967398 no 1973 0.428057486246291 653 6836383 SGTC_2800 7887935 81.82 µM -0.181528067364203 0.419160508750419 no 1974 0.42797655226627 649 2961002 SGTC_958 1222-0007 33 µM -0.182050813811106 0.418935872976406 no 1975 0.427771424241193 658 7312461 SGTC_2884 9058502 51.95 µM -0.182505465837847 0.418740520373222 no 1976 0.427593032638611 649 6471554 SGTC_2809 7964133 12.99 µM -0.18281514908186 0.418607468698728 no 1977 0.427471530841883 660 1253665 SGTC_92 0063-0024 660.874 µM -0.182817920500161 0.418606278034261 no 1978 0.427470443528644 612 3594437 SGTC_2431 5490079 200 µM -0.18292779022168 0.418559076098635 no 1979 0.427427338677783 665 5722345 SGTC_1231 0242-0792 125 µM -0.183094355966385 0.418487518805943 no 1980 0.427361992102442 655 3707635 SGTC_1936 st074407 74.3 µM -0.18359496071075 0.418272473303051 no 1981 0.427165608346952 617 809813 SGTC_3136 9095672 49.47 µM -0.185272858135899 0.417551874987012 no 1982 0.426507512769058 606 17217380 SGTC_1502 4534-4282 27.7 µM -0.185627829358653 0.417399462640753 no 1983 0.42636831408834 666 3278949 SGTC_2013 4024628 200 µM -0.186146450117358 0.417176807168671 no 1984 0.426164958250094 649 5230760 SGTC_60 0986-0278 202 µM -0.18650468584249 0.41702302407699 no 1985 0.426024502278139 631 3110598 SGTC_1498 4478-3555 97.6 µM -0.188979790439645 0.415960861606673 no 1986 0.425054328137194 637 3437919 SGTC_2048 5246248 200 µM -0.189295347637334 0.415825487828466 no 1987 0.424930670728289 616 677046 SGTC_1236 0330-0013 258 µM -0.189741341468413 0.415634173879392 no 1988 0.424755911711569 650 4617066 SGTC_587 k089-0003 57 µM -0.190242177372159 0.415419358658108 no 1989 0.424559680908642 624 9659696 SGTC_1881 5652484 16 µM -0.190559705345205 0.415283179750426 no 1990 0.424435281040289 673 2255129 SGTC_2986 9022445 71.43 µM -0.190594920258202 0.415268077681197 no 1991 0.42442148514275 654 6459286 SGTC_1698 5-fluorocytosine 1.055 µM -0.190625840407679 0.415254817543274 no 1992 0.424409371850699 615 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_214 4373-3496 70 µM -0.19078830177115 0.415185147406667 no 1993 0.424345727085219 648 3779166 SGTC_671 0560-0003 407 µM -0.192566295044876 0.414422845286574 no 1994 0.423649321742648 649 3238678 SGTC_1038 k292-0204 154 µM -0.193467739158844 0.414036480373379 no 1995 0.423296334577046 615 4454212 SGTC_2445 5742597 35.57 µM -0.194294355814681 0.413682260108446 no 1996 0.4229727024175 628 1774255 SGTC_848 0368-0089 85.6 µM -0.195634010945294 0.413108342783345 no 1997 0.422448318872297 663 762535 SGTC_1603 st002045 67.8 µM -0.196196000101451 0.412867638028565 no 1998 0.422228379338091 651 5887985 SGTC_2224 6650123 117.647 µM -0.197038447702481 0.412506871909512 no 1999 0.421898725299158 632 2908370 SGTC_2069 5228469 200 µM -0.199078685066098 0.411633476269387 no 2000 0.421100597178247 658 2835210 SGTC_2136 5328288 199.296 µM -0.199713822448708 0.411361672414718 no 2001 0.420852201402588 630 262395 SGTC_1237 0330-0133 46.1 µM -0.200458246222285 0.411043154152211 no 2002 0.420561104941141 663 X1237 YHR072W ERG7 SGTC_1107 amlodipine 47 µM -0.200469596527796 0.411038298124971 no 2003 0.420556666899374 650 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1154 4088-0362 150 µM -0.201191636347784 0.410729414220612 no 2004 0.420274365507024 635 6618304 SGTC_2751 anetholtrithion 17.25 µM -0.202044983797641 0.410364429153402 no 2005 0.419940778654877 663 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2992 9074591 71.4286 µM -0.202064430137386 0.410356112666726 no 2006 0.419933177446141 626 17741321 SGTC_2889 9059656 51.95 µM -0.205828927946341 0.408746938552354 no 2007 0.418462271876024 645 3949838 SGTC_2272 7805186 180 µM -0.206712824376015 0.40836932956199 no 2008 0.41811707065608 694 2956062 YPR165W RHO1 SGTC_697 0508-1955 564 µM -0.206868254326043 0.408302937188581 no 2009 0.418056374798582 648 6243113 SGTC_3173 9105693 49.47 µM -0.207273032979259 0.408130047120034 no 2010 0.417898316693839 669 17096658 SGTC_1085 doxorubicin 7.67 µM -0.207376491982116 0.408085860320943 no 2011 0.417857920114386 640 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3092 9117248 49.47 µM -0.207473193878714 0.408044560503447 no 2012 0.417820162696783 632 17141857 SGTC_101 0490-5701 117.494 µM -0.208329621429799 0.407678838774822 no 2013 0.417485802225308 631 4661669 SGTC_2185 6113692 200 µM -0.208384853744326 0.40765525558243 no 2014 0.417464240855309 638 874150 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.210535677005787 0.406737154272746 no 2015 0.416624804684488 622 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1620 st003704 16.5 µM -0.21097394699747 0.4065501368364 no 2016 0.416453800538186 614 2834414 SGTC_1991 st073000 8.92 µM -0.211126677735699 0.406484968976808 no 2017 0.416394211785745 657 4301969 YIL048W NEO1 SGTC_2666 tannic acid 100 µM -0.211771757659072 0.406209751876008 no 2018 0.416142551454671 641 16134267 A thiamine antagonist. SGTC_2283 7944793 200 µM -0.212182579705744 0.40603450277137 no 2019 0.41598229835404 617 2970533 SGTC_2390 9097792 176.6 µM -0.213073328334455 0.405654590549694 no 2020 0.415634883928645 639 4497149 SGTC_180 1486-1293 102.781 µM -0.213965320938611 0.405274236796651 no 2021 0.415287050390942 673 4140536 SGTC_412 gemfibrozil 100 µM -0.214250239384012 0.405152763813185 no 2022 0.415175960091883 624 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2290 7904846 200 µM -0.214459368406243 0.40506360893323 no 2023 0.415094424562645 651 2962154 SGTC_3264 9137442 49.47 µM -0.216311692001063 0.404274150829927 no 2024 0.414372397952534 661 17015726 SGTC_166 k072-0058 166.424 µM -0.217608271385558 0.403721781870087 no 2025 0.413867169647562 636 5846229 SGTC_1039 k821-0043 94 µM -0.218273167492737 0.403438597113068 no 2026 0.413608139832978 654 15992768 SGTC_233 rapamycin 362 pM -0.222016641207751 0.401845169574794 no 2027 0.412150464392386 638 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1957 st077035 62.4 µM -0.223079122926914 0.401393214999568 no 2028 0.411736963225126 654 705593 SGTC_2675 theaflavin digallate 100 µM -0.22314835938324 0.401363768020651 no 2029 0.411710020881936 649 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1461 k072-0203 53.8 µM -0.223189375378345 0.401346323759151 no 2030 0.411694060310268 647 5418714 SGTC_1790 st045711 43.5 µM -0.223222621967499 0.401332184000365 no 2031 0.411681123158065 636 585119 SGTC_78 0336-0123 156.75 µM -0.223494477145768 0.401216568969977 no 2032 0.411575340516804 626 6765896 SGTC_411 enrofloxacin 100 µM -0.224646181291757 0.400726866332153 no 2033 0.411127267748426 666 71188 A bacterial gyrase inhibitor. SGTC_3064 1327-0027 10 µM -0.227500451452564 0.39951390932334 no 2034 0.410017309114953 646 16000455 YPR107C YTH1 SGTC_2927 9011802 47.9 µM -0.227897284975358 0.399345346546797 no 2035 0.409863046733552 656 43912568 SGTC_1673 st016611 27.3 µM -0.227935554773226 0.399329091695445 no 2036 0.40984817072818 702 5226799 SGTC_2483 5729050 27.16 µM -0.227976492617154 0.399311703801832 no 2037 0.409832257759659 679 2865180 SGTC_3057 9095946 49.47 µM -0.22815895625463 0.399234206832064 no 2038 0.409761334040001 637 24540043 SGTC_164 4100-3994 89.624 µM -0.228734893368001 0.398989617684179 no 2039 0.409537486335159 650 4615967 SGTC_2882 9058044 58.44 µM -0.229816303677059 0.398530471231552 no 2040 0.409117257637817 666 18076804 SGTC_213 1246-0773 967 nM -0.230313185601036 0.398319551567379 no 2041 0.408924207683891 663 6251622 SGTC_3329 9141233 27.5565 µM -0.231611888002685 0.397768410365304 no 2042 0.408419736638254 674 4909101 YNL103W MET4 SGTC_165 k038-0023 64.381 µM -0.232709440998935 0.397302791599406 no 2043 0.40799351880375 651 46368543 SGTC_1523 st012844 44.7 µM -0.232855926345595 0.397240658658531 no 2044 0.407936641693624 673 4274103 SGTC_3052 9092717 49.47 µM -0.233068095216194 0.397150670145492 no 2045 0.40785426452384 663 25237534 SGTC_993 3909-8757 62.7 µM -0.235782875641857 0.395999718110939 no 2046 0.406800578413154 637 4288324 YLR208W SEC13 SGTC_519 k048-0011 62.8 µM -0.236136413523894 0.395849899474895 no 2047 0.40666340942892 647 6836379 SGTC_2075 5212009 200 µM -0.236802020988661 0.395567876977096 no 2048 0.406405191811297 651 780898 SGTC_3037 9091026 49.47 µM -0.237086811721735 0.395447225861842 no 2049 0.406294721724562 667 25236398 YIL048W NEO1 SGTC_3077 9117319 49.47 µM -0.23858955687194 0.394810756597825 no 2050 0.405711931855063 654 17154678 SGTC_3195 9113082 49.47 µM -0.239892285439324 0.394259228914383 no 2051 0.405206880795212 637 17018038 SGTC_43 0570-0105 72.5 µM -0.239898687271801 0.394256519134821 no 2052 0.405204399276346 659 1114046 YDL195W SEC31 SGTC_756 0508-1999 28.3 µM -0.240742469834871 0.393899406122579 no 2053 0.404877360324266 656 6753853 SGTC_1043 0916-0009 19.3 µM -0.241037988723836 0.393774355117941 no 2054 0.404762836809741 698 3101130 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.24257277110743 0.393125077034516 no 2055 0.404168188393494 653 5711223 A potent inhibitor of glutathione S-transferases. SGTC_496 calpeptin 138 µM -0.242815178826422 0.393022555411003 no 2056 0.404074288206328 649 73364 A calpain inhibitor. SGTC_1391 3442-0225 151 µM -0.244253578500097 0.392414365147194 no 2057 0.403517216857953 638 5227075 SGTC_3328 9140624 29.0385 µM -0.245078293393462 0.39206577406893 no 2058 0.403197904924489 672 4904392 SGTC_3072 9116419 49.47 µM -0.247545802841158 0.391023323688794 no 2059 0.402242924334051 667 17170162 SGTC_297 0986-0032 24 µM -0.248214717160166 0.390740861508001 no 2060 0.401984139977077 665 2847425 SGTC_533 1222-0222 6.71 µM -0.248453047920334 0.390640235593163 no 2061 0.401891946805813 678 3982874 SGTC_950 1165-0508 94.1 µM -0.249616349214019 0.390149181995443 no 2062 0.401442026954699 660 6148369 SGTC_254 nsc-64875 3.808 µM -0.250008336858856 0.389983755314212 no 2063 0.401290450722922 676 56993 SGTC_2196 6573537 42.6665 µM -0.250042164853951 0.389969480152407 no 2064 0.401277370598339 680 2903087 SGTC_3196 9111891 49.47 µM -0.250580185384081 0.38974245945977 no 2065 0.401069351408805 652 18891510 SGTC_3164 9100705 49.47 µM -0.251246639145218 0.389461297824047 no 2066 0.400811713939044 668 17174235 SGTC_3091 9116372 49.47 µM -0.251765022935368 0.389242643522043 no 2067 0.400611347128322 661 17169793 SGTC_281 1672-3440 14.9 µM -0.253543087956038 0.388492922442133 no 2068 0.39992428460824 660 6833000 SGTC_2935 9038016 29.96 µM -0.253617578311129 0.388461522628234 no 2069 0.399895507516957 666 6463195 SGTC_991 3996-0057 64.7 µM -0.254012637928741 0.388295005895261 no 2070 0.399742897296767 646 715343 SGTC_3118 9124250 49.47 µM -0.25497955103675 0.387887540887608 no 2071 0.399369446622076 666 1504786 SGTC_3181 9108277 49.47 µM -0.255016344896344 0.387872038092118 no 2072 0.399355237552512 686 17097298 SGTC_300 r073-0011 5.04 µM -0.255199723793424 0.38779477554082 no 2073 0.39928442219444 656 2735780 SGTC_169 k015-0017 16.025 µM -0.256591936276617 0.387208343386846 no 2074 0.398746900280858 716 1840002 SGTC_2970 9090938 41.86 µM -0.261786886569928 0.385022391473496 no 2075 0.396742874798905 656 17217104 SGTC_2512 diallyl trisulfide 49.23 µM -0.263671401968639 0.38423031584276 no 2076 0.396016566912175 669 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1709 st033179 39.1045 µM -0.264415967366851 0.383917502538344 no 2077 0.39572970452842 665 573381 SGTC_2220 6782180 200 µM -0.264529003422361 0.383870019451903 no 2078 0.395686159503359 682 833803 SGTC_459 nigericin 15.3 µM -0.264673250366667 0.383809428131001 no 2079 0.395630592958462 715 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_44 0929-0055 61.211 µM -0.264959688514195 0.383689117430767 no 2080 0.39552025806737 641 1379590 SGTC_1654 st012436 41.8 µM -0.265744247869527 0.383359641652035 no 2081 0.395218091673468 681 4323132 SGTC_1594 piperine 70.1 µM -0.266478050016683 0.383051557691199 no 2082 0.394935530996812 671 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1944 st076371 56.9 µM -0.266509471422223 0.383038367186969 no 2083 0.394923432982045 646 24208455 SGTC_3347 9188721 44.724 µM -0.267415471225724 0.38265809267865 no 2084 0.394574644369619 699 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_841 0251-0215 91.2 µM -0.268052959627109 0.382390587994203 no 2085 0.394329276957384 688 3888614 SGTC_3003 9075612 71.4286 µM -0.268131846536462 0.382357489145576 no 2086 0.394298916530962 701 6501993 SGTC_3198 9112019 49.47 µM -0.269379032999925 0.381834317244466 no 2087 0.393819009630554 705 45595555 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.27079603431165 0.381240172963726 no 2088 0.393273955061305 707 5282309 SGTC_105 0111-0055 734.78 µM -0.270910536798645 0.381192174624359 no 2089 0.393229920392178 699 5179370 SGTC_486 niguldipine 82 µM -0.271106704343701 0.381109947327553 no 2090 0.393154482647305 648 1236 A calcium channel blocker. SGTC_646 4092-0839 27.3 µM -0.272893989198275 0.380361021117335 no 2091 0.392467353573131 687 877796 SGTC_259 usnic acid 108.925 µM -0.273286108876395 0.380196771019298 no 2092 0.392316646284754 714 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2523 spermine 47.74 µM -0.273755932915264 0.380000000764666 no 2093 0.392136095368398 653 1103 A DNA binding polyamine. SGTC_900 1112-0045 141 µM -0.274454199269718 0.379707612401639 no 2094 0.391867798179213 669 56211 YIL048W NEO1 SGTC_1062 mesoridazine 14.2 µM -0.275622415481902 0.379218593550016 no 2095 0.39141904562196 663 4078 A neuroleptic. SGTC_1146 3579-1023 7 µM -0.275762189897861 0.379160096481581 no 2096 0.391365363063566 662 X1146 SGTC_2102 5377816 72.7585 µM -0.277476791220705 0.378442743266664 no 2097 0.390707012177851 697 1379702 SGTC_390 dec-rvkr-cmk 16.7 µM -0.278097595432592 0.378183114927668 no 2098 0.39046872076628 667 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2671 danthron 100 µM -0.278527240643293 0.378003463946273 no 2099 0.390303828498947 668 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2060 5238662 140 µM -0.278695443488533 0.37793313913066 no 2100 0.390239279798218 689 790130 SGTC_2883 9059145 45.46 µM -0.280173012030394 0.377315548773838 no 2101 0.389672385548587 667 16476510 SGTC_2558 carylophyllene oxide 100 µM -0.280654029490969 0.377114561907527 no 2102 0.389487885605204 684 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2521 angolensin 13.4 µM -0.281811457338096 0.376631082299891 no 2103 0.389044042587435 659 821428 A flavenoid. SGTC_347 4534-1311 26.2 µM -0.282260663542404 0.376443492397227 no 2104 0.388871822829444 676 2862016 SGTC_684 1140-0066 328 µM -0.282371409813314 0.376397248893179 no 2105 0.388829367517835 687 6813534 SGTC_1561 5-methoxyflavone 52.9 µM -0.282654741128335 0.376278948401043 no 2106 0.388720756638324 650 94525 SGTC_1960 st011366 51.8 µM -0.282890018162082 0.376180721043153 no 2107 0.388630573268309 651 3972846 SGTC_1348 1493-0373 93.8 µM -0.283228636493542 0.37603936312561 no 2108 0.388500788976539 702 3010129 SGTC_888 0916-0002 6.97 µM -0.283526329800284 0.375915103300722 no 2109 0.388386700546595 667 2802138 YIL048W NEO1 SGTC_2568 diosmetin 100 µM -0.283636046969144 0.375869309625889 no 2110 0.38834465480196 683 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_905 2-aminofluorene 215 µM -0.28402801327913 0.375705725285491 no 2111 0.388194456408626 651 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2951 9072950 58.06 µM -0.286812249609015 0.374544388641898 no 2112 0.38712804149813 671 16488155 SGTC_1439 4092-1168 46 µM -0.286983504598856 0.374472993253735 no 2113 0.387062475326655 675 2886240 SGTC_125 0133-0007 11.75 µM -0.287008932435766 0.374462392876734 no 2114 0.387052740376026 689 26541 SGTC_1301 naphtanilide LB 4.81 µM -0.287764256292914 0.374147556166216 no 2115 0.386763599935105 689 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.289176623788856 0.373559073566444 no 2116 0.386223109768567 698 688751 SGTC_549 1661-1316 519 µM -0.289554276235199 0.373401769292632 no 2117 0.386078625649615 697 2857282 SGTC_3176 9106582 49.47 µM -0.292820642060705 0.372042106676332 no 2118 0.384829624701437 656 17018027 SGTC_2489 cantharidin 73.42 µM -0.293097369138755 0.371926988832199 no 2119 0.384723863819291 692 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1714 st033236 13.627 µM -0.294178300479679 0.371477433602341 no 2120 0.384310830554294 704 2916566 SGTC_2638 epoxomicin 18 µM -0.295862348058764 0.370777394022184 no 2121 0.383667603157765 674 9915668 A protesome inhibitor. SGTC_120 rhodamine 6G 52.259 µM -0.296023687386967 0.370710349489646 no 2122 0.383605995873994 686 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2389 9091542 195.52 µM -0.296176843559402 0.370646709098218 no 2123 0.383547516043438 663 3626624 YOL127W RPL25 SGTC_2238 6671620 73.2395 µM -0.296251313963888 0.370615765978045 no 2124 0.383519081865572 666 729941 SGTC_3149 9097855 49.47 µM -0.296767056507358 0.370401493309954 no 2125 0.383322179046578 656 25236625 YMR079W SEC14 SGTC_3191 9110352 49.47 µM -0.296854178581819 0.370365301156834 no 2126 0.383288920110506 681 17122424 SGTC_1343 1487-0095 224 µM -0.297040009162984 0.370288107462666 no 2127 0.383217981980989 709 4560101 YGL055W OLE1 SGTC_1558 st069300 45.6 µM -0.297350733399493 0.370159044836298 no 2128 0.383099376258198 691 24208000 SGTC_2567 aureobasidin a 60 nM -0.297832038585123 0.369959158456158 no 2129 0.382915680171015 662 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3103 9120822 49.47 µM -0.299447867884063 0.369288360595052 no 2130 0.382299171702757 703 17141819 SGTC_2271 7849410 118.62 µM -0.299496398467138 0.3692682196772 no 2131 0.382280659800962 718 972430 SGTC_1335 1486-0900 202 µM -0.299786590640358 0.36914779307489 no 2132 0.382169972145421 650 X1335 SGTC_1817 st052116 64.4 µM -0.30102548653707 0.368633809296978 no 2133 0.381697529964664 680 4361398 SGTC_2051 5263410 176 µM -0.303133648549059 0.367759731361473 no 2134 0.380894005985246 662 227584 SGTC_759 3486-0358 89.3 µM -0.303784761213365 0.367489907688691 no 2135 0.380645938606705 695 875103 SGTC_2529 gangaleoidin 93.61 µM -0.303885717129432 0.367448077009803 no 2136 0.380607479808679 669 4565183 SGTC_1046 2001-0062 216 µM -0.304024123359207 0.367390731499921 no 2137 0.380554756364152 687 739778 SGTC_389 tpck 16.7 µM -0.30484839337017 0.367049275040673 no 2138 0.380240811027755 680 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_385 1494-0393 12.4 µM -0.306097069270635 0.36653220745166 no 2139 0.379765369643615 697 3090647 SGTC_3079 9117512 49.47 µM -0.306122864940169 0.366521528202704 no 2140 0.379755549689585 696 7185044 SGTC_2332 7982454 138.89 µM -0.306405474098686 0.366404536514403 no 2141 0.379647970473415 710 2981748 SGTC_474 dl-dihydrosphingosine 5 µM -0.306769356428756 0.366253918462388 no 2142 0.37950946718249 670 3058739 A sphingolipid protein kinase C inhibitor. SGTC_701 4424-0219 185 µM -0.30869047181158 0.365459073038712 no 2143 0.378778496244492 703 2911779 SGTC_703 3875-0075 71.8 µM -0.308748356003313 0.365435132883188 no 2144 0.378756478428386 695 2850814 SGTC_2874 9043904 71.43 µM -0.309684367650332 0.365048083372727 no 2145 0.378400495785271 687 4463428 SGTC_1242 0402-0103 60.1 µM -0.310460113141227 0.364727409550491 no 2146 0.378105543517897 672 432868 SGTC_2605 digitonin 300 nM -0.310971892004765 0.364515904729165 no 2147 0.377910994944923 685 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1375 2910-0797 186 µM -0.311436921883505 0.364323755798994 no 2148 0.377734244463931 688 742508 SGTC_451 chloral hydrate 100 µM -0.313770426458708 0.363360074469232 no 2149 0.37684770356514 709 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_371 0195-0006 7.36 µM -0.31452949555432 0.36304678314236 no 2150 0.376559459043186 657 3928593 SGTC_1055 3448-0672 86 µM -0.315611696507823 0.362600283758291 no 2151 0.376148629312173 711 748378 SGTC_668 1682-0499 62.6 µM -0.318032572556952 0.361602144796082 no 2152 0.375230114645991 673 682214 SGTC_2976 9009005 19.48 µM -0.318599401104413 0.361368574340413 no 2153 0.375015153822845 667 2993148 SGTC_2180 6301957 200 µM -0.318983903994144 0.36121016338955 no 2154 0.374869359233777 697 845462 SGTC_2788 5282734 71.43 µM -0.319027746373104 0.361192102323711 no 2155 0.374852736354532 729 743706 SGTC_3110 9122132 49.47 µM -0.320521421752271 0.360576961094423 no 2156 0.374286547011777 667 918317 SGTC_3268 9137683 49.47 µM -0.320568694229297 0.360557498720814 no 2157 0.374268632427508 704 1953228 SGTC_3257 9139206 32.98 µM -0.320793662072375 0.360464883007535 no 2158 0.374183381352323 706 4910041 SGTC_469 w7 172 µM -0.321269642801115 0.360268956235215 no 2159 0.37400302977288 674 45115570 A P450 inhibitor. SGTC_2235 salicylic acid 500 µM -0.321289363674073 0.360260839372215 no 2160 0.373995558026011 684 338 A COX inhibitor and kinase inhibitor. SGTC_954 1189-0853 2.85 µM -0.322998441287398 0.359557644169137 no 2161 0.373348211262227 687 2828194 SGTC_3273 9137859 49.47 µM -0.324893256864125 0.358778583199108 no 2162 0.372630930266845 682 2377234 SGTC_1211 1056-0033 32.3 µM -0.325823547362933 0.358396305248832 no 2163 0.37227893093011 699 6741922 SGTC_2823 7987624 58.44 µM -0.326101368995669 0.358282169387139 no 2164 0.372173830643935 747 2239440 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.329472292330273 0.35689832390653 no 2165 0.370899366725084 673 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3295 9122362 53.5725 µM -0.329494627430957 0.356889161060976 no 2166 0.370890927071575 710 4730473 SGTC_2622 2-methoxyxanthone 59.94 µM -0.329791683704918 0.356767303299911 no 2167 0.370778685801215 675 71034 A hepatoprotective. SGTC_1485 3909-9022 254 µM -0.330017235039784 0.356674787896263 no 2168 0.370693469668173 692 714516 SGTC_1229 0139-0193 12.2 µM -0.331175332704441 0.356199898662946 no 2169 0.370256025772452 685 3090752 SGTC_343 4130-2827 29.8 µM -0.331806795316175 0.355941055140886 no 2170 0.370017576397416 674 1118244 SGTC_2897 9048598 12.99 µM -0.331968633111449 0.355874726718486 no 2171 0.369956472154355 683 6467404 SGTC_3088 9117578 49.47 µM -0.334188782142967 0.354965250778025 no 2172 0.369118554211562 679 678341 SGTC_251 melphalan 456.522 µM -0.33452082131693 0.354829303005529 no 2173 0.368993290920348 700 460612 A DNA alkylator. SGTC_3238 9133470 49.47 µM -0.334949613052886 0.354653768897275 no 2174 0.368831547870454 692 3534688 SGTC_2099 5377090 177.372 µM -0.336137831246237 0.354167510364754 no 2175 0.368383465639257 711 2243829 SGTC_1977 st070720 65.3 µM -0.336958330520709 0.353831873365896 no 2176 0.36807415621068 693 682188 SGTC_483 fpl-64176 144 µM -0.337971346068354 0.353417641509206 no 2177 0.367692390528634 693 3423 SGTC_1737 st035557 69.7 µM -0.340882587528721 0.352228174299486 no 2178 0.36659598686129 683 5716916 SGTC_2347 9049783 174.81 µM -0.342404439161133 0.351606954235032 no 2179 0.366023274107844 746 6467988 YPL169C MEX67 SGTC_3289 9119912 71.43 µM -0.342749254314693 0.351466255615727 no 2180 0.365893552522697 748 17014829 SGTC_613 3914-0030 117 µM -0.343660860420053 0.351094381270615 no 2181 0.365550674565028 673 1145395 SGTC_3001 9076041 71.4286 µM -0.344485505061116 0.350758104175085 no 2182 0.365240597513562 694 16004211 SGTC_1912 st060209 90.8 µM -0.344576823409487 0.350720873174795 no 2183 0.365206266046514 735 688787 SGTC_998 3996-0085 177 µM -0.344620216937173 0.350703181893819 no 2184 0.365189952469692 676 715391 SGTC_2334 9017922 200 µM -0.346270981293209 0.350030415896296 no 2185 0.364569537387437 686 3163164 SGTC_727 3032-0951 202 µM -0.348348920905696 0.349184224380535 no 2186 0.363789079081882 708 3652836 SGTC_2655 perillic acid 100 µM -0.349907700774366 0.348549939881546 no 2187 0.363203983777212 701 5702197 An apoptosis inducer. SGTC_1139 k015-0024 46.9 µM -0.350314812287862 0.348384351398113 no 2188 0.363051225062033 729 2766652 SGTC_1440 4100-1550 40 µM -0.350595577309948 0.348270169901254 no 2189 0.362945887492488 708 742806 SGTC_1772 st048439 82.2 µM -0.35078012912387 0.348195123873399 no 2190 0.362876652892418 681 2927068 YDL195W SEC31 SGTC_667 1498-1044 59 µM -0.351524365178186 0.347892548556154 no 2191 0.362597498290234 713 6739982 SGTC_1770 st043884 66.3 µM -0.352447400255154 0.347517415557867 no 2192 0.362251379637976 702 670149 SGTC_292 k038-0015 474 µM -0.353743833449186 0.346990781035907 no 2193 0.361765434747256 727 46368540 SGTC_383 2324-0395 7.37 µM -0.356470416761485 0.345884158725006 no 2194 0.360744151469107 720 3146421 SGTC_2925 9010536 32.5 µM -0.357742379219385 0.345368364091596 no 2195 0.36026805754826 702 2994177 SGTC_1156 4092-0367 4.88 µM -0.357757365787365 0.34536228858409 no 2196 0.360262449384709 702 1357585 SGTC_3 0833-0587 95.581 µM -0.358001833423692 0.345263187800739 no 2197 0.360170970745468 692 5382644 SGTC_976 1348-1067 47.6 µM -0.358025912031797 0.345253427536821 no 2198 0.36016196107663 686 5310671 YGL099W LSG1 SGTC_3308 9128332 17.569 µM -0.359157008286184 0.344795053736122 no 2199 0.359738818120059 705 17332805 YDL196W YDL196W SGTC_2791 5663188 71.43 µM -0.359337513023873 0.344721925716171 no 2200 0.359671307211475 735 54690634 SGTC_1755 st041960 45.185 µM -0.361669319473436 0.343777761629736 no 2201 0.358799578330255 740 2257073 SGTC_561 1550-0330 72.9 µM -0.362132359704236 0.343590389200153 no 2202 0.358626561427749 716 6812934 SGTC_2491 paeonol 100 µM -0.36231577253145 0.343516180553719 no 2203 0.358558036483603 690 11092 Increases levels of cortical cytochrome oxidase. SGTC_1245 0418-0076 17.2 µM -0.362714071670945 0.343355049892889 no 2204 0.358409243457097 740 6790114 SGTC_1364 1653-0028 37.6 µM -0.363392822640096 0.343080528933797 no 2205 0.358155731282861 709 5718652 SGTC_2868 9035608 32.47 µM -0.36341456550752 0.343071736394879 no 2206 0.358147611396869 679 6462614 SGTC_1080 nisoldipine 24.4 µM -0.365071242468309 0.342402047501573 no 2207 0.357529113392528 730 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2023 5144124 124 µM -0.365505755990207 0.342226483270133 no 2208 0.357366955471598 710 2830192 SGTC_363 0455-0021 3.06 µM -0.365589859046446 0.342192505552781 no 2209 0.357335571673564 708 4597466 SGTC_1041 0206-0046 107 µM -0.365614792389061 0.342182432703377 no 2210 0.357326267762046 724 50494 SGTC_1397 3532-0190 20.1 µM -0.365665472765005 0.342161958626836 no 2211 0.357307356570599 684 5322280 SGTC_1699 st031318 29.054 µM -0.365777803768613 0.34211658031826 no 2212 0.357265441928888 713 5340658 SGTC_194 1486-1323 56.904 µM -0.367903670290728 0.341258225444383 no 2213 0.356472531697451 693 5178754 SGTC_1863 st057641 20.1 µM -0.368196621901104 0.341140005473106 no 2214 0.356363314509279 711 3921635 SGTC_582 0987-0078 156 µM -0.368312518366403 0.341093240015933 no 2215 0.356320109648622 720 1625765 SGTC_606 k015-0008 38.6 µM -0.368394385032181 0.341060207416097 no 2216 0.356289591814727 725 1970475 SGTC_1093 fluphenazine 7.97 µM -0.368777203566165 0.340905759112771 no 2217 0.356146898911243 727 6602611 An atypical antipsychotic. SGTC_3060 1327-0027 12.5 µM -0.372431721768073 0.33943268746915 no 2218 0.3547857196628 714 16000455 YPR107C YTH1 SGTC_396 dithiazanine 1.25 µM -0.37250786267277 0.339402022396169 no 2219 0.354757379492981 692 10578 An antihelmenthic. SGTC_522 1273-0010 11.6 µM -0.37296777059937 0.339216821181006 no 2220 0.354586215686757 701 5705015 SGTC_2737 bleomycin 30.5 nM -0.375263258289488 0.338293028241834 no 2221 0.353732344224434 715 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2111 5486399 200 µM -0.375300585533801 0.338278014337797 no 2222 0.353718465366409 697 689674 SGTC_2175 5807670 165.306 µM -0.376073134405089 0.337967334601693 no 2223 0.353431263192164 693 241186 SGTC_721 1187-1332 279 µM -0.37670885925958 0.337711761246502 no 2224 0.353194989177141 714 25730 SGTC_2745 rifampicin 24.3 µM -0.37677587530117 0.337684823893855 no 2225 0.353170085235782 686 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2217 6934799 96.0675 µM -0.37724697015381 0.337495489001144 no 2226 0.352995038655453 716 675606 SGTC_2068 5226020 147 µM -0.377348574792271 0.33745465908404 no 2227 0.352957289094315 736 1810509 SGTC_2470 5664817 21.68 µM -0.37750102638982 0.337393399859824 no 2228 0.352900650882464 716 2859561 SGTC_3296 9122258 64.045 µM -0.379459725674307 0.336606724775493 no 2229 0.352173253063696 713 4730474 SGTC_1447 4239-0816 81.9 µM -0.381393138001969 0.335830906362559 no 2230 0.351455776011063 724 1341554 SGTC_431 k089-0097 107 µM -0.381611309246199 0.335743404841659 no 2231 0.351374847209895 728 5499420 SGTC_1519 esterone 74 µM -0.381745093937324 0.335689752477233 no 2232 0.351325224228231 701 698 A steroid. SGTC_499 genistein 192 µM -0.382559116212228 0.335363373150526 no 2233 0.351023344388085 721 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_296 1222-0039 74.9 µM -0.382713750631077 0.335301387064492 no 2234 0.350966008893204 715 5984176 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.38380419952522 0.334864401802728 no 2235 0.350561787624246 701 676296 Flavone; oxidizing agent. SGTC_2858 9025781 8.96 µM -0.384165063870349 0.334719838622513 no 2236 0.350428055132292 715 4894980 YPL153C RAD53 SGTC_651 3253-0966 34.4 µM -0.384879725472415 0.33443361565989 no 2237 0.350163263861166 707 781462 SGTC_13 0199-0087 65 µM -0.385177416591699 0.334314418330273 no 2238 0.350052986969504 709 4589825 SGTC_320 4092-0846 5.34 µM -0.386413524672876 0.333819651958207 no 2239 0.349595217636032 699 1359356 SGTC_1454 4239-0054 42.6 µM -0.386453385845102 0.333803701870808 no 2240 0.349580459437191 739 1340767 SGTC_1326 1431-2094 10.8 µM -0.386496121010791 0.333786602114483 no 2241 0.349564637423642 735 616278 SGTC_2793 7325131 81.82 µM -0.388137967835887 0.333129906454858 no 2242 0.348956967938029 713 4176441 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.388232065706889 0.333092285248561 no 2243 0.34892215277245 755 688798 SGTC_1670 st016595 4.04 µM -0.388819491185453 0.332857465049171 no 2244 0.348704840642417 722 597879 SGTC_1077 5-fluorocytosine 377 nM -0.391504015400055 0.331785176153356 no 2245 0.347712360598637 742 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_982 1491-0518 27.5 µM -0.393090592606143 0.33115209066668 no 2246 0.347126286010528 702 3091256 SGTC_1164 k060-0068 93.7 µM -0.394722011076838 0.330501615308083 no 2247 0.346524028309455 707 5963676 SGTC_48 0382-0018 55 µM -0.394791434652168 0.330473946239968 no 2248 0.346498408354366 702 762596 SGTC_507 nimesulide 162 µM -0.395488910354013 0.330196015705342 no 2249 0.346241052120591 721 4495 A COX2 inhibitor. SGTC_200 k038-0079 37.545 µM -0.39572061187194 0.330103707865085 no 2250 0.346155574047833 713 3436683 SGTC_1735 st034310 56.75 µM -0.39624909828571 0.329893202242324 no 2251 0.345960637023926 735 871153 SGTC_1305 1181-0477 144 µM -0.396569685589359 0.329765532806862 no 2252 0.345842405366584 702 6252086 SGTC_1256 0570-0116 285 µM -0.397116628330164 0.329547766250865 no 2253 0.345640729189161 731 410638 SGTC_1943 st076331 65.2 µM -0.397450369664422 0.329414914726985 no 2254 0.345517689052285 730 24208415 SGTC_2762 leflunomide 42.06 µM -0.397557416386007 0.329372307483339 no 2255 0.345478227683678 711 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2106 5357045 167.29 µM -0.397649495336647 0.329335659555286 no 2256 0.345444285330849 717 668842 SGTC_1799 st045822 46.1415 µM -0.397715138889782 0.329309534061652 no 2257 0.34542008841334 747 3674992 SGTC_2141 5621638 7.665 µM -0.398057242768671 0.329173393547239 no 2258 0.345293995482349 735 2856238 SGTC_310 1273-0058 1.06 µM -0.398181323124282 0.329124021266233 no 2259 0.345248266084531 712 2734232 SGTC_2877 9040724 71.43 µM -0.399471295259727 0.328610910688743 no 2260 0.344772985139349 719 6463895 SGTC_649 1123-0311 367 µM -0.400265208926903 0.328295277149567 no 2261 0.34448059504243 743 693629 YIL048W NEO1 SGTC_2600 tangeritin 87.95 µM -0.400801653568582 0.328082074040618 no 2262 0.3442830806777 728 68077 A bioactive flavone. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.401173906265436 0.327934159842884 no 2263 0.344146045347343 736 5357218 A potent inhibitor of glutathione S-transferases. SGTC_560 2332-1943 155 µM -0.401921019239753 0.327637376776254 no 2264 0.34387107653655 735 21177716 SGTC_2306 7482397 179.52 µM -0.401968367809234 0.327618571702668 no 2265 0.343853653063796 760 891448 SGTC_1354 1498-1681 81 µM -0.402395058685637 0.327449125841535 no 2266 0.343696653001301 731 5754243 SGTC_1260 0700-1617 7.75 µM -0.402429440820142 0.32743547368566 no 2267 0.343684003336194 689 2853078 SGTC_771 0250-0039 27.3 µM -0.402515192127928 0.327401425315375 no 2268 0.343652455000984 723 3005115 SGTC_3206 9114350 49.47 µM -0.403078419357167 0.327177826296237 no 2269 0.343445267958241 730 17087243 SGTC_2264 7948757 110.76 µM -0.403377862885482 0.327058973622694 no 2270 0.343335134725088 709 2971411 SGTC_2555 cholic acid 100 µM -0.405472181565333 0.326228204632841 no 2271 0.342565231302624 727 6708657 Influences liver metabolism. SGTC_706 4262-0057 46.9 µM -0.405912118833755 0.326053800798413 no 2272 0.342403586630439 723 883298 SGTC_1674 st016616 23.6 µM -0.407154976023925 0.325561301976167 no 2273 0.34194708382565 694 625830 SGTC_823 0417-1665 178 µM -0.408098899299429 0.325187463033206 no 2274 0.341600534049447 751 3429856 SGTC_158 k038-0087 26.446 µM -0.408727309531175 0.324938679902517 no 2275 0.341369894982085 691 X158 SGTC_2867 9039098 71.43 µM -0.409444745309232 0.324654747607979 no 2276 0.341106654183907 708 6463460 SGTC_834 0312-0008 75.7 µM -0.410564176425301 0.324211925204943 no 2277 0.340696068146954 745 6385573 YIL048W NEO1 SGTC_3231 9132313 49.47 µM -0.411691560659013 0.323766207903231 no 2278 0.340282755735356 740 4905967 SGTC_2159 5658611 73.75 µM -0.412461423128944 0.323461983832373 no 2279 0.340000625210734 734 793844 SGTC_901 1112-0062 60.1 µM -0.412723344502606 0.323358508093784 no 2280 0.33990465963078 711 1908457 SGTC_1940 st075990 51.1 µM -0.41347004639501 0.323063587976469 no 2281 0.339631131891506 736 1084979 SGTC_1417 3966-0327 90.4 µM -0.413931577896725 0.322881355394852 no 2282 0.339462108420077 726 651118 SGTC_515 4092-1064 102 µM -0.413948285971344 0.322874759122173 no 2283 0.339455990143536 773 717353 SGTC_2541 muurolladie-3-one 83.07 µM -0.414327954770798 0.322724882611215 no 2284 0.339316971845817 746 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1066 ketoconazole 628 nM -0.41514187117502 0.322403681332564 no 2285 0.339019024558359 751 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_16 erodoxin 22.806 µM -0.415244746574895 0.322363092354645 no 2286 0.338981372513295 746 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3023 9089636 49.47 µM -0.419595467056064 0.320648480854349 no 2287 0.337390500181758 741 17249241 SGTC_162 k030-0015 37.8 µM -0.420128341490728 0.320438737802679 no 2288 0.337195849755896 732 1809920 YMR134W ERG29 SGTC_2659 sanguinarine 24.21 µM -0.420309578844381 0.320367414594246 no 2289 0.337129656605002 751 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_423 5-fluorouracil 457 µM -0.421880684512603 0.319749408096552 no 2290 0.336556054634287 719 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2441 5730946 39.09 µM -0.422073599668048 0.319673557875149 no 2291 0.336485648556302 698 1774275 SGTC_1861 st057647 17.4 µM -0.422669201090286 0.319439427395987 no 2292 0.33626831477305 747 688668 SGTC_335 4077-0256 27.6 µM -0.422861688670564 0.319363776053334 no 2293 0.33619808812868 743 3121989 SGTC_2302 7771753 200 µM -0.42332786647487 0.319180590319148 no 2294 0.336028032777435 702 2203047 SGTC_2324 6149169 200 µM -0.424018773443368 0.318909177893954 no 2295 0.335776060998972 742 2888231 SGTC_1403 3909-7815 62.9 µM -0.42455913552989 0.318696972409504 no 2296 0.335579043935062 719 6615483 SGTC_604 1000-0114 314 µM -0.425144632171635 0.318467109237199 no 2297 0.335365621739896 751 1572745 SGTC_1838 st055369 84.5 µM -0.425169291195607 0.318457429755182 no 2298 0.335356634325813 688 676036 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.425432144327944 0.318354258913607 no 2299 0.335260838744658 762 5393153 SGTC_1184 1269-1718 139 µM -0.425496141407117 0.318329141951796 no 2300 0.335237516933063 709 5403821 SGTC_1147 3809-1045 12.3 µM -0.426048956241746 0.318112213245083 no 2301 0.335036086629761 714 325925 SGTC_2050 5263056 171 µM -0.427238606473373 0.317645597163634 no 2302 0.334602772221591 730 763468 YGL055W OLE1 SGTC_479 n-linoleoylglycine 10 µM -0.427610242615107 0.317499889767233 no 2303 0.334467453769532 747 6433346 An anti-infammatory. SGTC_1316 1272-0050 65.9 µM -0.42791294590768 0.317381229765424 no 2304 0.33435725072031 757 7340392 SGTC_3202 9113761 49.47 µM -0.428479430808115 0.317159217529117 no 2305 0.334151052922017 748 4798415 SGTC_217 ketoconazole 989 nM -0.428634756911551 0.317098354852924 no 2306 0.334094523701905 721 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_849 0386-0493 241 µM -0.428825051484072 0.317023796943827 no 2307 0.334025273223498 737 726119 SGTC_1181 1222-0449 220 µM -0.429295303318864 0.316839582914765 no 2308 0.333854167178364 742 658318 SGTC_119 0121-0043 24.815 µM -0.429373020963883 0.316809142575819 no 2309 0.333825892125874 754 1092378 SGTC_1209 2323-2347 50.3 µM -0.430123649272875 0.316515201386343 no 2310 0.333552848868917 701 5412760 SGTC_3130 9127414 49.47 µM -0.431123151705941 0.316123982555788 no 2311 0.333189413759648 743 1494646 SGTC_3227 9130768 49.47 µM -0.431353529562007 0.316033838699633 no 2312 0.33310566687053 740 17720899 SGTC_73 0327-0325 16.231 µM -0.433393894156291 0.315235948445352 no 2313 0.332364317791655 731 53298 SGTC_1916 st067606 49.2 µM -0.433728462202314 0.315105196755965 no 2314 0.33224281781139 707 19590279 SGTC_980 1473-0395 201 µM -0.434728011542692 0.314714703432811 no 2315 0.331879931762547 742 768876 SGTC_627 1391-0720 175 µM -0.434933334746921 0.314634515571234 no 2316 0.331805408751426 736 997839 SGTC_2082 5219693 150 µM -0.43507769842201 0.314578140356193 no 2317 0.331753015268936 741 2834649 SGTC_1153 4055-0057 267 µM -0.435297524524859 0.314492304738672 no 2318 0.331673240751046 731 882706 SGTC_2088 5278280 127.392 µM -0.438324300265557 0.313311459105255 no 2319 0.33057560646775 744 791502 SGTC_1762 st045503 25.4615 µM -0.440468900224663 0.312475935561822 no 2320 0.329798766054654 740 4645554 SGTC_322 k048-0136 19.3 µM -0.440978676772425 0.312277471122756 no 2321 0.329614217016566 727 6823282 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.441526712047477 0.312064172665352 no 2322 0.329415863843932 726 16486 A toxic proline analog. SGTC_3248 9135562 49.47 µM -0.441572207245869 0.312046468505284 no 2323 0.329399399693853 725 17650701 SGTC_2850 9015429 58.44 µM -0.443449859647637 0.311316171397795 no 2324 0.328720189329617 740 6457570 SGTC_2606 farnesol 9.78 µM -0.443634096370206 0.311244554002254 no 2325 0.328653575101577 744 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1475 4092-1048 11.7 µM -0.443980991822589 0.311109726505784 no 2326 0.32852816334966 750 2881759 SGTC_2904 7225135 42.03 µM -0.444468719847248 0.31092020462831 no 2327 0.328351869620163 767 4446116 SGTC_1743 st037606 46.3785 µM -0.44453370279047 0.310894957271101 no 2328 0.328328383828535 697 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_910 3454-3003 490 µM -0.444874991244228 0.310762373530916 no 2329 0.328205048300717 764 820824 SGTC_877 0771-0151 33.1 µM -0.445119115125748 0.310667551355346 no 2330 0.328116837793644 741 6166523 SGTC_2031 5180455 200 µM -0.445130015317804 0.310663317814859 no 2331 0.328112899396059 741 29949 SGTC_34 0469-0683 81.75 µM -0.446506927064783 0.310128738948235 no 2332 0.327615554990639 724 3690923 SGTC_3332 9141069 11.198 µM -0.448007876694168 0.309546459843782 no 2333 0.327073755996589 725 17332883 SGTC_1288 0973-0013 65.5 µM -0.448103885457697 0.309509230401028 no 2334 0.327039112018976 729 4315430 SGTC_1111 tnp00062 510.699 nM -0.448420320378192 0.309386539861878 no 2335 0.326924939616893 718 676306 SGTC_163 TUB2.036 7.546 µM -0.449246744149862 0.309066212819383 no 2336 0.326626835337258 747 15992207 YJR013W GPI14 SGTC_2377 9073351 62.6 µM -0.449411189142083 0.309002490212021 no 2337 0.326567530591868 766 7337946 YHR072W ERG7 SGTC_2658 polymyxin b sulfate 77.05 µM -0.449974756138574 0.308784151016662 no 2338 0.326364321432293 732 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1967 st070177 51.4 µM -0.450084209379701 0.308741754073291 no 2339 0.326324861111304 772 5729214 SGTC_2349 9023730 187.07 µM -0.450768865306151 0.308476609016755 no 2340 0.326078071589879 755 4126287 SGTC_141 0443-0274 32.331 µM -0.451379263201229 0.308240305877 no 2341 0.325858113158495 734 1627241 SGTC_1870 st057514 26.5 µM -0.451717603435651 0.308109358547921 no 2342 0.325736217494084 719 5393161 SGTC_2940 9060638 45.86 µM -0.452269752402803 0.307895713589685 no 2343 0.325537331813118 725 4027022 SGTC_2189 6047310 154.431 µM -0.452467741511485 0.307819120815442 no 2344 0.325466027647723 738 711535 SGTC_1034 k072-0165 12.7 µM -0.45445294343757 0.30705160189233 no 2345 0.324751426816214 763 5835461 SGTC_1285 0929-0069 65.5 µM -0.454833312922654 0.306904639739208 no 2346 0.324614581065477 731 1206237 SGTC_1803 st050068 52.4 µM -0.45631907556898 0.30633088777483 no 2347 0.324080274351144 744 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_249 wiskostatin 11.211 µM -0.457022728822907 0.306059325865567 no 2348 0.323827354412198 730 2775510 A n-wasp and actin depolymerizer. SGTC_1128 3448-9350 235 µM -0.457641601468072 0.305820571517765 no 2349 0.323604975084249 704 619386 SGTC_1763 st044482 94.5 µM -0.458754600616952 0.305391396187366 no 2350 0.323205199934797 756 88505 SGTC_220 paclitaxel 373.376 µM -0.460786508101629 0.304608577242792 no 2351 0.32247589121357 746 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_605 1315-0399 119 µM -0.460896538862334 0.304566211937575 no 2352 0.322436417539085 738 24020461 SGTC_323 4013-0906 34.3 µM -0.461312752009026 0.304405980495884 no 2353 0.322287118657271 736 2910086 SGTC_728 3030-5151 22.5 µM -0.461909696130292 0.304176237767595 no 2354 0.322073040214297 729 3125388 SGTC_1716 st033144 30.6155 µM -0.463717617718767 0.303480904310632 no 2355 0.321425036589562 778 674617 SGTC_1567 st069303 68.4 µM -0.464821743018063 0.303056603081746 no 2356 0.321029557871706 752 5581319 SGTC_2799 7812892 81.82 µM -0.465038667337408 0.302973273043744 no 2357 0.320951883143873 772 20205235 SGTC_660 4031-1742 102 µM -0.466098500997302 0.302566292496962 no 2358 0.320572498103503 735 6738706 SGTC_203 k066-0004 30.888 µM -0.466891172863304 0.302262063455507 no 2359 0.320288870512682 753 6795412 SGTC_3133 9127736 49.47 µM -0.46804326882087 0.301820131643989 no 2360 0.319876823786254 736 27243420 SGTC_2182 6325192 200 µM -0.468220600488957 0.301752134891366 no 2361 0.319813420891321 732 736248 SGTC_3353 9151644 39.2805 µM -0.468407396746915 0.301680516448072 no 2362 0.319746639734432 745 4909158 SGTC_2603 homopterocarpin 100 µM -0.468726733535219 0.301558099134303 no 2363 0.319632487810782 737 101795 A weak amylase inhibitor. SGTC_1506 4226-2149 212 µM -0.470135556058076 0.301018295966957 no 2364 0.31912908626832 749 991114 SGTC_1695 st026914 34.495 µM -0.471031205153648 0.300675346511753 no 2365 0.318809225505927 752 3289191 SGTC_1434 4073-0095 163 µM -0.471179899004897 0.300618427810159 no 2366 0.318756135922073 758 24133745 SGTC_2765 myclobutanil 7.74 µM -0.471380657093291 0.300541587093631 no 2367 0.318684463248149 787 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1671 st016596 74.5 µM -0.471760399803792 0.300396263776442 no 2368 0.318548909798317 733 2829167 SGTC_86 0417-1630 471.922 µM -0.472147137312812 0.300248296267504 no 2369 0.31841088443316 756 3634867 SGTC_2281 7943571 200 µM -0.472634753563561 0.300061779074461 no 2370 0.318236891691887 759 1244024 SGTC_1464 k208-0027 110 µM -0.473263867756134 0.299821215231857 no 2371 0.318012468455958 772 X1464 SGTC_1539 benzyladenosine 56 µM -0.473327118560355 0.299797033903586 no 2372 0.317989908758924 723 92208 A nucleotide analog. SGTC_2498 4'-Methoxychalcone 54.63 µM -0.473870428129282 0.299589358349489 no 2373 0.317796154078648 736 641818 YHR062C RPP1 SGTC_765 1319-0117 244 µM -0.47422671789278 0.299453204959783 no 2374 0.317669121347338 718 3487746 YGL099W LSG1 SGTC_1290 0986-0249 10.2 µM -0.478856440612148 0.297686548884216 no 2375 0.31602038059422 758 53329 SGTC_1662 st014054 52 µM -0.480027913277984 0.297240281634284 no 2376 0.315603772504406 756 2838777 SGTC_3302 9125395 16.351 µM -0.481879946609844 0.296535382357549 no 2377 0.314945616212785 734 17599668 SGTC_1833 st055984 71 µM -0.482591879434068 0.296264618758356 no 2378 0.314692773079056 729 676288 SGTC_3002 9075603 71.4286 µM -0.482680981338516 0.296230739343428 no 2379 0.314661134627157 740 20105405 SGTC_1610 st001799 48.1 µM -0.483590511014635 0.295885008555909 no 2380 0.314338255190562 730 621897 SGTC_2844 9010103 25.97 µM -0.485098925336473 0.295312038376839 no 2381 0.313803087171839 790 2480525 SGTC_1883 5-benzylidenerhodanine 20 µM -0.485138251238931 0.295297107290549 no 2382 0.313789140026644 761 1273210 SGTC_662 k832-1615 104 µM -0.485830038493067 0.295034509367847 no 2383 0.313543837439951 755 5878478 SGTC_3174 9107204 49.47 µM -0.485911233713243 0.295003695247571 no 2384 0.313515051625567 768 3938802 SGTC_1606 st000094 49.2 µM -0.486330451353392 0.294844622989343 no 2385 0.313366446156277 748 1242210 SGTC_3143 9086658 49.47 µM -0.48649549300705 0.29478200873354 no 2386 0.313307950028241 736 25236626 SGTC_3321 9137793 26.8275 µM -0.486818291865474 0.29465956155417 no 2387 0.313193553194907 730 4904192 SGTC_2467 5474540 200 µM -0.487211086589563 0.294510594518245 no 2388 0.313054374740693 728 5413519 SGTC_2202 7226349 200 µM -0.487310632430869 0.294472847370923 no 2389 0.313019107018909 721 844334 SGTC_2830 7992007 71.43 µM -0.488550770989935 0.294002782058085 no 2390 0.312579886491768 763 1952075 SGTC_860 0443-0016 25.1 µM -0.491797073284058 0.292773940896716 no 2391 0.311431402862337 762 5337942 SGTC_692 k241-0027 77.8 µM -0.493027061402362 0.292308970329099 no 2392 0.310996733182726 769 3600480 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.493379164368803 0.292175928628892 no 2393 0.310872350811641 763 688667 SGTC_1465 k213-0056 144 µM -0.495008929199277 0.291560491201909 no 2394 0.310296908770399 759 24048857 YMR208W ERG12 SGTC_1287 0971-0001 34.6 µM -0.495094748488408 0.291528100585704 no 2395 0.310266620300726 734 4665869 SGTC_1401 3807-4679 7.6 µM -0.495500306422956 0.291375054309795 no 2396 0.310123502885836 768 3291456 SGTC_521 r062-0005 13.8 µM -0.495683502720087 0.291305933420744 no 2397 0.310058864138323 751 2832033 SGTC_2270 7924575 90.91 µM -0.49709139217286 0.290774985187286 no 2398 0.309562302224856 758 1262135 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.497812105630421 0.290503362405621 no 2399 0.309308241334544 749 6857784 SGTC_24 0417-1663 219 µM -0.498022734909503 0.290424002786598 no 2400 0.309234008972316 782 4329390 SGTC_2484 5809818 12.04 µM -0.499467188754728 0.289880043897517 no 2401 0.308725148071264 750 2870548 SGTC_806 3966-4455 5.86 µM -0.499781028548793 0.289761919925249 no 2402 0.308614635201297 777 714982 SGTC_1201 1889-3372 45.9 µM -0.501634105428879 0.289064914040946 no 2403 0.307962462086149 752 5392199 SGTC_1336 1486-0901 104 µM -0.502022373658674 0.28891897300284 no 2404 0.307825891433058 742 5006114 SGTC_324 1315-0088 19.6 µM -0.503332891276644 0.28842663596805 no 2405 0.307365122596268 775 6787421 SGTC_1283 0922-0125 16.4 µM -0.503818037853049 0.288244475795032 no 2406 0.307194625477154 753 3360884 SGTC_1151 3909-8316 15.3 µM -0.505643218795235 0.287559653406363 no 2407 0.306553567906133 767 800431 SGTC_577 r071-0003 38.6 µM -0.506284591939679 0.287319187879453 no 2408 0.306328439004695 761 4568517 YMR134W ERG29 SGTC_3228 9131799 49.47 µM -0.506421322952233 0.287267936587646 no 2409 0.306280454391972 761 17015818 SGTC_1297 1068-0111 14.1 µM -0.506646798147534 0.287183430500791 no 2410 0.306201333003017 761 767057 SGTC_3168 9103419 49.47 µM -0.507799310638758 0.286751663031287 no 2411 0.305797046648408 774 16649256 SGTC_3089 9117425 49.47 µM -0.508140762653958 0.286623803471043 no 2412 0.305677315135768 791 9401657 SGTC_3094 9117742 49.47 µM -0.508649759954663 0.286433255388397 no 2413 0.305498871764813 800 17149698 SGTC_2893 9048488 25.97 µM -0.510573550625452 0.28571360919402 no 2414 0.304824850163804 748 6467338 SGTC_2174 5790901 200 µM -0.511760295756593 0.285270104302125 no 2415 0.304409390609843 777 786020 SGTC_62 0180-0423 3.232 µM -0.511791037957296 0.285258619828972 no 2416 0.304398631631221 789 30102 YGL099W LSG1 SGTC_891 0929-0073 133 µM -0.512298888318584 0.28506893224932 no 2417 0.304220921583537 793 5603632 SGTC_1259 0671-0132 43 µM -0.512764954298235 0.284894904521077 no 2418 0.304057873656861 742 X1259 SGTC_962 1254-0300 21.5 µM -0.513682827064795 0.284552321669461 no 2419 0.303736880166893 747 7340576 SGTC_1721 st082152 9.2685 µM -0.513993742553266 0.284436321544973 no 2420 0.303628182785201 749 5296051 SGTC_3278 9139605 49.47 µM -0.514087431908539 0.284401371213263 no 2421 0.303595431991979 782 7958859 SGTC_2313 7726885 200 µM -0.514461354177998 0.284261901877087 no 2422 0.303464736474082 749 726423 SGTC_1568 digitonin 820 nM -0.51465194001452 0.284190827812361 no 2423 0.303398131459239 800 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2678 equilin 100 µM -0.515002864997647 0.284059981636037 no 2424 0.303275508985865 744 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2087 5276107 200 µM -0.515156312654686 0.284002776074172 no 2425 0.30322189727733 766 144405 SGTC_1127 asiatic acid 681.4 nM -0.515338588559062 0.283934830453335 no 2426 0.303158219031445 764 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1855 st056195 39.6 µM -0.517178533295944 0.283249404023685 no 2427 0.302515767916417 744 4028379 SGTC_512 prima-1 270 µM -0.517392974057724 0.283169571028441 no 2428 0.302440931641868 765 322968 A re-activator of the apoptotic function of mutant p53. SGTC_887 0885-0007 9.62 µM -0.517997928170086 0.282944414125874 no 2429 0.302229857432798 768 5719458 SGTC_3192 9110362 49.47 µM -0.519081689406246 0.282541265832983 no 2430 0.301851888289704 773 16649480 SGTC_850 0388-0143 75.9 µM -0.519203162550648 0.282496096261045 no 2431 0.301809536942079 767 67273 SGTC_935 2996-0153 430 µM -0.519308398221247 0.282456967372088 no 2432 0.301772848913661 781 23738523 SGTC_1419 3993-2473 62.6 µM -0.521304218802673 0.281715372183963 no 2433 0.301077431276279 777 704026 SGTC_2419 paclitaxel 166.5 µM -0.5224060134817 0.281306376366735 no 2434 0.300693834973574 779 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2972 9093619 59.92 µM -0.522535236300634 0.281258426513627 no 2435 0.300648859744093 740 25236256 SGTC_1137 ixabepilone 100 µM -0.523870696427713 0.280763117453022 no 2436 0.300184238791827 764 154225 A novel microtubule stabilizer. SGTC_1474 0330-0125 5.35 µM -0.523971089657925 0.280725899642635 no 2437 0.300149324030787 772 X1474 SGTC_2677 mitomycin C 100 µM -0.526212324451245 0.279895650207932 no 2438 0.299370345952386 780 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1009 4106-0057 9.87 µM -0.526326769705159 0.279853286757138 no 2439 0.299330593234024 781 2928005 SGTC_2003 4023581 200 µM -0.526641342522584 0.279736859420698 no 2440 0.299221338264954 742 16641307 SGTC_2601 securinine 100 µM -0.527149289526748 0.279548911506813 no 2441 0.299044960296281 788 442872 A GABA receptor antagonist. SGTC_2786 7743617 45.45 µM -0.527506046508912 0.279416942802666 no 2442 0.298921109317855 758 583674 SGTC_83 0170-0301 39.027 µM -0.52828614372704 0.279128480917571 no 2443 0.298650373675469 764 3089716 SGTC_1927 st060202 13.8 µM -0.532352329932695 0.277627247992691 no 2444 0.297240997419168 757 688887 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.534853159165755 0.276705906877861 no 2445 0.296375700259616 785 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2388 9080168 200 µM -0.535110864217144 0.276611049879315 no 2446 0.296286598925492 784 15943073 SGTC_17 0960-0276 49.807 µM -0.53539747294994 0.276505572633252 no 2447 0.296187518595308 784 6821114 SGTC_1954 st077032 68.9 µM -0.535585803570023 0.2764362742649 no 2448 0.296122421179406 804 698907 SGTC_815 1582-0027 36.9 µM -0.535910899005777 0.276316671789932 no 2449 0.296010065774705 767 3128206 SGTC_3245 9134821 49.47 µM -0.53686112103077 0.275967231117848 no 2450 0.295681774209469 791 17014901 SGTC_135 0933-0004 26.348 µM -0.540190994834262 0.274744397893612 no 2451 0.294532661155175 781 21230617 YGL099W LSG1 SGTC_601 0986-0029 62.9 µM -0.541048150475187 0.274430056599573 no 2452 0.294237197392904 783 24747981 SGTC_1710 st031758 61.5 µM -0.541747651689723 0.274173662888501 no 2453 0.293996179026645 780 5394341 SGTC_2931 9014674 55.67 µM -0.54188687422932 0.274122646672024 no 2454 0.293948219754671 771 2996810 SGTC_1840 st055363 71 µM -0.543315757461082 0.273599322956626 no 2455 0.293456208410182 776 676033 SGTC_1669 st015249 58.4 µM -0.544110154301694 0.27330859174635 no 2456 0.293182836631688 793 722793 SGTC_3082 9117008 49.47 µM -0.545022150876901 0.272975010478245 no 2457 0.29286914152074 765 41448529 SGTC_2734 clemastine 41.6 µM -0.545159269568454 0.272924873994564 no 2458 0.292821990934736 789 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2789 5281112 71.43 µM -0.546701967325308 0.272361112317038 no 2459 0.292291751202058 765 765948 SGTC_377 3970-0964 33.1 µM -0.547072201813137 0.272225900381751 no 2460 0.292164564604919 774 16481235 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.547247294384286 0.272161967107557 no 2461 0.292104424051301 779 16725076 SGTC_138 0850-0259 40.9225 µM -0.547898633578566 0.271924202757434 no 2462 0.291880753565953 773 6813004 SGTC_903 1134-0042 114 µM -0.549750855865761 0.27124863417968 no 2463 0.29124513509164 768 701009 SGTC_2372 9071633 200 µM -0.552326593700949 0.270310567637445 no 2464 0.290362306778199 769 21321366 SGTC_2040 5100729 123 µM -0.552967349322298 0.270077460881994 no 2465 0.29014288402353 783 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2496 diffractaic acid 79.83 µM -0.553064911257371 0.270041976695559 no 2466 0.290109481366313 766 94870 An apoptosis inducer which activates caspases. SGTC_127 0180-0333 59.125 µM -0.554792108488465 0.269414165399923 no 2467 0.289518432759124 761 771601 SGTC_3285 9112818 20.8695 µM -0.555017479037757 0.269332300453661 no 2468 0.28944135245928 792 17017947 YPR165W RHO1 SGTC_1319 1306-0155 43.7 µM -0.555635775743762 0.269107770732473 no 2469 0.289229934700967 784 3122360 SGTC_2855 9016525 58.44 µM -0.555749111261692 0.269066623994334 no 2470 0.289191189107779 774 43811474 SGTC_351 caspofungin 25 nM -0.556044933894259 0.268959239739016 no 2471 0.289090068820148 772 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_299 1273-0059 1.44 µM -0.556186054572733 0.268908020208548 no 2472 0.289041835761753 777 2848077 SGTC_1352 1496-0991 99 µM -0.556723085236251 0.268713150556697 no 2473 0.288858320871735 800 3000039 SGTC_1363 1636-0063 10.4 µM -0.557032733675441 0.268600822220299 no 2474 0.288752532294513 776 6072185 SGTC_420 mitomycin C 81.9 mM -0.558208868932704 0.268174381533493 no 2475 0.288350882687342 764 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1052 3253-3998 198 µM -0.56104607567474 0.267147077196432 no 2476 0.287383063685545 766 5450317 SGTC_2851 9015922 71.43 µM -0.561153850359928 0.26710809301483 no 2477 0.287346330239301 799 2996893 SGTC_566 0958-0068 16.5 µM -0.561385049306283 0.267024473588614 no 2478 0.28726753690942 795 6815365 SGTC_3276 9139060 49.47 µM -0.561480390147306 0.266989994814339 no 2479 0.287235047428004 792 4870619 SGTC_880 0833-0487 87.2 µM -0.563777960073441 0.266159789107872 no 2480 0.286452626543182 782 76075 SGTC_1853 st056710 91.2 µM -0.564271476437624 0.265981632204568 no 2481 0.286284695147623 789 269167 SGTC_883 0850-0245 24.6 µM -0.564369033128916 0.265946421886664 no 2482 0.28625150455604 792 6823229 YPR165W RHO1 SGTC_1289 0976-0073 69.1 µM -0.564378751386407 0.265942914486887 no 2483 0.286248198325094 794 3391136 SGTC_778 3456-2434 196 µM -0.565090209958018 0.265686206860785 no 2484 0.286006203552612 765 5539063 SGTC_248 streptozotocin 5.23457 mM -0.565810294017678 0.265426514993193 no 2485 0.285761373963697 812 5300 DNA alkylating agent. SGTC_689 0833-0039 98 µM -0.566308985814022 0.265246741783402 no 2486 0.285591876499856 830 5374726 SGTC_3236 9132701 49.47 µM -0.56652345806439 0.265169445780883 no 2487 0.285518995486424 787 24282524 SGTC_1795 st049545 62.3 µM -0.566768762393867 0.265081051893686 no 2488 0.285435648107773 736 5291882 SGTC_2620 irigenin 100 µM -0.568236950892635 0.264552312380913 no 2489 0.284937042077293 794 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_244 nsc-207895 1.295 µM -0.568758512777936 0.264364611266184 no 2490 0.284760016441184 765 42640 SGTC_3172 9105863 49.47 µM -0.569221400637298 0.264198082721664 no 2491 0.284602949593574 782 2348785 SGTC_1875 nocodazole 6 µM -0.570135889729108 0.263869243222626 no 2492 0.284292767320113 785 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_580 1123-0028 41 µM -0.57136780830541 0.263426589941447 no 2493 0.283875172914972 793 1677248 YPR107C YTH1 SGTC_984 1492-0255 2.91 µM -0.573120982329951 0.26279729328379 no 2494 0.283281390641564 793 1585198 SGTC_3026 9090633 49.47 µM -0.574343753198926 0.26235883886202 no 2495 0.282867603464488 781 25236842 SGTC_2386 9075165 157.42 µM -0.574974054467942 0.262132975328226 no 2496 0.282654422172946 788 16452277 SGTC_1036 k216-0215 33.5 µM -0.575307202262921 0.262013634684653 no 2497 0.282541775704929 769 622330 SGTC_641 4092-0595 30 µM -0.575474112097892 0.261953854497399 no 2498 0.282485346997945 790 786260 SGTC_1909 st060837 51.5 µM -0.575635901046871 0.261895915074721 no 2499 0.282430654727842 797 678937 SGTC_1836 st055642 81 µM -0.576919251356879 0.261436558046895 no 2500 0.281997002512528 799 8571 SGTC_2974 9094440 9.66 µM -0.577168141237666 0.261347519370754 no 2501 0.281912938185462 763 25236134 SGTC_526 4469-0568 170 µM -0.578046269308739 0.261033499445634 no 2502 0.281616440665681 766 2901964 SGTC_1663 st014140 55.4 µM -0.578285179517779 0.260948098373661 no 2503 0.281535799323385 778 4207120 SGTC_3138 9097216 49.47 µM -0.5821890780193 0.259554645543588 no 2504 0.28021966466404 805 25237486 SGTC_543 3844-1095 191 µM -0.582197855862445 0.259551516725691 no 2505 0.280216708721477 793 4230703 SGTC_2818 7996756 12.99 µM -0.583436194939959 0.25911031226672 no 2506 0.279799848948601 808 2241621 SGTC_540 1187-0821 17.3 µM -0.585806968738056 0.258266718825526 no 2507 0.279002620085245 811 847520 SGTC_1622 st003707 19.4 µM -0.588125027461281 0.257443261533737 no 2508 0.278224187699349 779 10140899 SGTC_2832 7992762 51.95 µM -0.588149879133556 0.257434440727822 no 2509 0.27821584794568 759 2985177 SGTC_2593 nobiletin 86.24 µM -0.589774093568437 0.256858285774247 no 2510 0.277671056617371 786 72344 An anti-infammatory. SGTC_2471 5466956 24.79 µM -0.590518762859293 0.256594354984325 no 2511 0.277421455212916 796 724419 SGTC_909 3448-9333 149 µM -0.590912108897421 0.256454999616759 no 2512 0.277289656108357 794 3344074 SGTC_1215 3852-0577 11.2 µM -0.591279857112091 0.256324748769491 no 2513 0.277166461814085 774 2884876 SGTC_439 amiodarone 34.4 µM -0.594124526532712 0.255318376080672 no 2514 0.276214413820296 796 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_57 miconazole 162.5 nM -0.596303927801888 0.254548758228556 no 2515 0.275486103791127 796 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1102 cgs 12066b 26.1 µM -0.597570344458485 0.254102104026054 no 2516 0.275063328372539 778 6438352 A 5-HT1B full agonist. SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.599112180094366 0.253558867374142 no 2517 0.274549039957388 806 1273210 SGTC_2784 7567673 72.73 µM -0.60185218595795 0.25259498571134 no 2518 0.273636266992724 794 3471247 SGTC_555 4296-0685 37 µM -0.602714761546506 0.252291948070207 no 2519 0.273349229874372 816 2908540 YHR072W ERG7 SGTC_930 2810-3379 265 µM -0.602887847327671 0.252231163156459 no 2520 0.273291650519783 825 1015764 SGTC_1462 k081-0014 26.5 µM -0.603021978658051 0.252184063724517 no 2521 0.273247034028508 785 3270634 SGTC_3098 9119039 49.47 µM -0.60305747880757 0.25217159883102 no 2522 0.273235226115297 799 17161528 SGTC_746 1095-0025 46.6 µM -0.603815651916551 0.251905464954353 no 2523 0.272983106070358 816 6749286 SGTC_137 0438-0332 85.389 µM -0.604476478537952 0.251673622608048 no 2524 0.272763451378853 822 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.606661542696087 0.250907824634037 no 2525 0.272037774462055 798 4174840 SGTC_3040 9091894 49.47 µM -0.607423221079621 0.250641169905809 no 2526 0.271785040949749 766 25236966 SGTC_2697 mebhydrolin 72.4 µM -0.607493646672833 0.250616522309488 no 2527 0.271761678843252 793 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2650 prasterone 100 µM -0.607587344516135 0.250583731866038 no 2528 0.271730598240726 780 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3304 9125678 46.087 µM -0.607994968720296 0.25044110638965 no 2529 0.271595405414854 806 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_924 2046-0044 21.3 µM -0.60885035112639 0.250141952694246 no 2530 0.271311817832315 795 3623589 SGTC_875 0709-0210 25.7 µM -0.609664348283909 0.249857448805327 no 2531 0.271042087938672 809 6251364 SGTC_1835 st008666 49.2 µM -0.610189630154435 0.249673946353898 no 2532 0.270868099124942 793 690455 SGTC_1047 2043-3044 82 µM -0.610365176577438 0.249612636766617 no 2533 0.270809965412862 840 669592 SGTC_2206 7254556 146.969 µM -0.610578041125255 0.249538304553993 no 2534 0.270739481837387 782 4398905 SGTC_2381 9035592 200 µM -0.610954795644673 0.249406770865261 no 2535 0.270614753572834 804 4749657 SGTC_2939 9044578 71.43 µM -0.611568873177807 0.249192461247251 no 2536 0.270411518736942 801 2653634 SGTC_2371 9071574 200 µM -0.612580368063687 0.248839668830685 no 2537 0.27007692121913 803 45596039 SGTC_47 0149-0135 24.25 µM -0.616283789575707 0.247550249844194 no 2538 0.268853617889813 787 5239155 SGTC_3022 9087993 49.47 µM -0.618303753133497 0.246848467171643 no 2539 0.268187564181084 801 17173644 SGTC_1865 st057639 52.2 µM -0.619470070547252 0.246443746655141 no 2540 0.267803366397519 817 688818 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.620576241708723 0.246060226116246 no 2541 0.26743923783258 808 97141 SGTC_418 lividomycin a 100 µM -0.621333911522696 0.245797719328021 no 2542 0.267189972845028 793 72394 An antibiotic. SGTC_409 arachidonic acid 100 µM -0.621436263128064 0.24576226951206 no 2543 0.267156309291642 794 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1627 st003713 25.6 µM -0.621804197868152 0.245634856774233 no 2544 0.267035312843184 796 16195070 YER133W GLC7 SGTC_2443 5493264 126.67 µM -0.622295061744868 0.245464929949942 no 2545 0.266873933874435 815 5340055 SGTC_1752 st044819 83.042 µM -0.622635877060412 0.245346983966672 no 2546 0.266761914642815 796 441209 YML126C ERG13 SGTC_425 3825-7017 13.1 µM -0.623865371562442 0.244921745980529 no 2547 0.266358001788376 807 3397440 SGTC_3224 9130643 49.47 µM -0.624195423821947 0.244807660318992 no 2548 0.266249625914397 815 17644395 SGTC_3155 9099265 49.47 µM -0.624452666685662 0.244718761747859 no 2549 0.266165173195166 814 25236499 SGTC_2054 5233173 129 µM -0.625112582920521 0.244490785909619 no 2550 0.265948585028324 762 6889 SGTC_1597 7-benzyloxygramine 47.5 µM -0.627245569275369 0.24375470386857 no 2551 0.265249138355425 813 260807 SGTC_1739 st037196 92.5 µM -0.627764233524231 0.243575896629099 no 2552 0.265079199786269 812 612214 SGTC_264 promethazine 12.5 mM -0.627989971800815 0.243498096472617 no 2553 0.265005254688377 832 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_134 0269-0018 6.916 µM -0.628257817687479 0.243405801445072 no 2554 0.264917529995827 799 4378915 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.628807036741265 0.243216609257173 no 2555 0.264737696334453 798 15053 SGTC_2929 9013348 24.6 µM -0.629568496488513 0.24295443704291 no 2556 0.264488470328185 797 2995952 SGTC_1839 st053978 48 µM -0.630135934223258 0.242759166479408 no 2557 0.264302825452739 811 3788398 SGTC_325 2810-4341 181 µM -0.632328569871 0.242005420638968 no 2558 0.263586099280817 798 774970 SGTC_1792 st045773 43.6 µM -0.633147008878471 0.241724397689774 no 2559 0.263318823297057 764 2919270 SGTC_3109 9122853 49.47 µM -0.633697950061597 0.241535323807045 no 2560 0.26313898151096 837 1234709 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.639233533299819 0.239640068173275 no 2561 0.261335510188067 831 6710655 SGTC_191 3914-0123 66.505 µM -0.639507292510673 0.239546550452935 no 2562 0.261246485552993 827 3144412 SGTC_198 3454-2873 16.191 µM -0.63957715624753 0.239522687790231 no 2563 0.261223768836408 814 710957 SGTC_2119 5528445 120.635 µM -0.640212169343301 0.239305852194098 no 2564 0.261017336128608 808 791935 SGTC_75 0159-0059 199.013 µM -0.642439419014402 0.238546169751997 no 2565 0.260293956086658 849 5377270 SGTC_782 0083-0095 30.5 µM -0.642659197929333 0.23847127798802 no 2566 0.260222630953242 814 3591729 An indicator and reagent. SGTC_2145 5634607 200 µM -0.643154758431307 0.238302458261631 no 2567 0.260061843034988 820 308662 SGTC_3104 9120930 49.47 µM -0.646153268219676 0.237282370985078 no 2568 0.259090050289972 825 17014836 SGTC_918 glabranin 770.725 nM -0.647084340820479 0.236966110511593 no 2569 0.258788679682221 799 124049 Also referred to as licorice root. SGTC_2171 5739187 198.077 µM -0.648195552950903 0.23658896492806 no 2570 0.258429238916738 799 2262761 SGTC_2942 9052777 62.25 µM -0.648799956461335 0.236383969027272 no 2571 0.258233842807515 846 6469503 SGTC_517 1365-0151 113 µM -0.649138411208147 0.236269217850898 no 2572 0.258124458071112 811 768657 SGTC_854 0422-0053 192 µM -0.649628262070244 0.236103191014311 no 2573 0.257966186385777 820 3596728 SGTC_235 0330-0087 5 mM -0.650017891399109 0.235971178513166 no 2574 0.257840332412077 810 46494818 YHR062C RPP1 SGTC_2195 6536160 144.242 µM -0.650261364063556 0.235888706828136 no 2575 0.257761704608432 802 3834386 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.652349145358891 0.235182163699306 no 2576 0.257087981441681 809 115019 SGTC_3018 9082602 49.47 µM -0.653117307691484 0.234922498008323 no 2577 0.256840327543016 826 17332089 SGTC_480 am 92016 50 µM -0.654451489684618 0.234471874696663 no 2578 0.256410485393066 858 2129 K+ channel blocker. SGTC_2284 7945075 39.21 µM -0.654490560044388 0.234458685795841 no 2579 0.256397903491183 818 1245402 SGTC_2838 9002687 71.43 µM -0.654979036973549 0.234293826295705 no 2580 0.256240625501369 818 6457060 SGTC_1632 st005650 90 µM -0.6615944949608 0.232067458956402 no 2581 0.254115568278996 812 2759605 SGTC_2875 9039966 71.43 µM -0.665238784774318 0.230846057840092 no 2582 0.252948888585188 827 6463691 SGTC_907 3448-6986 75.5 µM -0.665977487384477 0.230598916450719 no 2583 0.252712745060247 831 590582 SGTC_757 1066-0008 322 µM -0.666388882908548 0.23046134350603 no 2584 0.252581283230395 807 6842497 SGTC_2902 5787006 60.46 µM -0.666621834463554 0.230383463563202 no 2585 0.25250685931881 816 591003 SGTC_2117 5521686 200 µM -0.666842192660761 0.230309807353636 no 2586 0.252436469399016 814 803312 SGTC_3237 9133362 49.47 µM -0.668872689086395 0.229631720330471 no 2587 0.251788346603436 835 43845137 SGTC_1626 st003712 1.76 µM -0.669286216842281 0.22949375937918 no 2588 0.25165645868724 840 24207035 SGTC_1294 1000-1494 117 µM -0.671847026749553 0.228640458229872 no 2589 0.250840543529048 818 712797 YDL207W GLE1 SGTC_2822 7994718 71.43 µM -0.67196551834383 0.228601018188662 no 2590 0.250802824132078 855 1018011 SGTC_2448 5185112 27.17 µM -0.673997304261668 0.227925331070486 no 2591 0.250156513766509 805 5718189 SGTC_2817 7995342 71.43 µM -0.675913429858272 0.227289138514236 no 2592 0.24954780525555 834 18879975 SGTC_2803 7707263 71.43 µM -0.677170509920935 0.226872306596256 no 2593 0.24914888808107 816 2199229 SGTC_2725 haloperidol 53.21 µM -0.67794357269617 0.226616182991238 no 2594 0.248903735710878 825 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_305 1682-2595 20.8 µM -0.678204136192048 0.226529892429146 no 2595 0.248821135191623 830 226033 SGTC_3259 9138485 49.47 µM -0.678368650546821 0.226475419923609 no 2596 0.248768990463801 809 17646153 SGTC_2520 obtusaquinone 4.71 µM -0.678668132788286 0.226376277061198 no 2597 0.248674081041936 831 5967872 SGTC_2888 9058547 12.99 µM -0.678736610270422 0.226353611202149 no 2598 0.248652382436879 812 16476514 SGTC_2952 9073731 13.78 µM -0.679716323805051 0.226029469095602 no 2599 0.248342048986484 833 16457353 SGTC_2416 tofa 880 nM -0.679924294598319 0.225960694910911 no 2600 0.248276198863733 819 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1120 ficusin 1.78878 µM -0.680474378551083 0.225778843837123 no 2601 0.24810206979488 842 6199 A DNA cross-linker. SGTC_2560 caryophyllene 100 µM -0.681405826244165 0.225471107384161 no 2602 0.247807368651096 827 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_899 1083-0020 478 µM -0.682644106751672 0.22506236581216 no 2603 0.247415878086722 838 767123 SGTC_2166 5933061 31.504 µM -0.684291356901907 0.224519279597888 no 2604 0.246895601827976 835 2877375 SGTC_3334 9142812 21.919 µM -0.685482023511835 0.224127189032555 no 2605 0.246519900250289 826 45283678 SGTC_3298 9116858 71.43 µM -0.68568221385227 0.224061303883435 no 2606 0.246456762512038 856 2506942 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.68622421219412 0.22388298066528 no 2607 0.246285865945883 832 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3141 9094609 49.47 µM -0.687349036765272 0.223513158919089 no 2608 0.245931402271439 848 25236309 YDL196W YDL196W SGTC_2835 9006588 71.43 µM -0.687415648328669 0.223491269159104 no 2609 0.245910419694762 796 2345538 SGTC_1172 0370-0043 85 µM -0.687887315002823 0.223336305884649 no 2610 0.245761872648327 827 376585 SGTC_1281 0884-0031 11.8 µM -0.689140084622467 0.222925012908227 no 2611 0.245367558489123 842 1548255 SGTC_2598 perillyl alcohol 100 µM -0.690154740297742 0.222592210879497 no 2612 0.245048441023663 831 10819 An apoptosis inducer. SGTC_1214 0358-0031 63.7 µM -0.690430201173876 0.222501909989969 no 2613 0.244961844885062 853 4301366 SGTC_2774 tamoxifen 10.92 µM -0.690520728780925 0.222472238019519 no 2614 0.244933389479714 841 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1981 st071826 47 µM -0.691734467797953 0.222074632319687 no 2615 0.244552048579251 820 11838600 SGTC_636 0kpi-0074 126 µM -0.694007709633608 0.221331039171326 no 2616 0.243838687014606 838 616434 SGTC_2177 5811945 192 µM -0.694513675364668 0.221165728218962 no 2617 0.243680063835218 824 5343475 SGTC_3053 9095903 49.47 µM -0.694586678956731 0.221141882054263 no 2618 0.243657181387564 870 17174018 SGTC_183 3914-0051 30.55 µM -0.694882502907077 0.221045268078721 no 2619 0.243564469388491 817 1596232 SGTC_1353 1498-1206 8.11 µM -0.696402629397282 0.220549186841598 no 2620 0.243088358419686 817 6756808 SGTC_1510 1123-0200 71.5 µM -0.697032793891613 0.220343724833997 no 2621 0.242891135519755 851 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_93 0109-0045 59.227 µM -0.699106272250717 0.219668452528256 no 2622 0.242242809503597 845 88733 SGTC_3241 9133421 49.47 µM -0.699198339063389 0.219638496592134 no 2623 0.24221404422569 862 17018221 SGTC_2226 7298446 200 µM -0.7012150553512 0.218982902909544 no 2624 0.241584407807637 842 3283010 SGTC_1298 1079-1278 263 µM -0.701265083289124 0.218966654157998 no 2625 0.24156879995351 845 2840950 SGTC_1340 1486-1359 257 µM -0.701918907110883 0.21875436016414 no 2626 0.241364868541156 830 4309068 SGTC_1220 1838-0075 193 µM -0.70253022463892 0.218555974986497 no 2627 0.24117427972767 822 5529645 SGTC_426 0988-0037 14.6 µM -0.704743453252064 0.217838603527178 no 2628 0.240484952146406 839 5383008 SGTC_287 k060-0039 29.6 µM -0.705380981455206 0.217632214400389 no 2629 0.240286588169692 838 5861974 SGTC_928 2764-0428 58.7 µM -0.705502412133942 0.21759291603948 no 2630 0.240248815680924 843 662578 SGTC_2397 5161689 200 µM -0.706075422945999 0.217407528994702 no 2631 0.24007061736801 844 2259942 SGTC_1018 4259-0013 28.1 µM -0.706657107900116 0.21721942889973 no 2632 0.239889795246405 842 6801262 SGTC_2846 9008642 19.48 µM -0.706669144432992 0.217215537626008 no 2633 0.239886054364036 868 2992898 SGTC_1341 1486-1360 280 µM -0.70681675808578 0.217167819091582 no 2634 0.239840179512357 851 3976547 SGTC_1741 st038134 10.228 µM -0.710905440072715 0.215848494477732 no 2635 0.238571417341074 833 1272587 SGTC_867 0518-0118 155 µM -0.711596025792293 0.215626117608417 no 2636 0.23835748436696 842 6848158 SGTC_65 0798-0905 34.986 µM -0.711646312635894 0.215609929833225 no 2637 0.23834191037086 871 3602145 SGTC_3140 9094243 49.47 µM -0.711686253296129 0.215597073087174 no 2638 0.238329541017921 848 19291112 SGTC_1963 st076565 50.3 µM -0.712115492664798 0.215458930636999 no 2639 0.238196630677492 863 4914280 SGTC_1252 0493-0875 34.8 µM -0.716033915289891 0.214200237352155 no 2640 0.2369852036902 826 3960963 SGTC_3281 9140613 49.47 µM -0.717512168883519 0.213726499786869 no 2641 0.236529065281508 826 16013766 SGTC_1884 5633444 25 µM -0.71940705455794 0.213120137083851 no 2642 0.235945075740666 840 5724239 SGTC_1108 betulinic acid 729.144 nM -0.721193397194195 0.21254942807483 no 2643 0.235395266829417 825 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_889 0919-1524 82.7 µM -0.721495148538179 0.212453111366647 no 2644 0.235302462248777 853 3905452 SGTC_2694 st077685 81.9 µM -0.722021993782742 0.212285007555945 no 2645 0.23514047775786 827 2838096 SGTC_2338 7999974 200 µM -0.72424747864218 0.211575766469894 no 2646 0.234456907439841 854 315925 SGTC_773 4358-1457 44.6 µM -0.724294155625346 0.211560905822701 no 2647 0.234442582120773 865 1186886 SGTC_348 k064-0012 10.7 µM -0.726415968286868 0.210886025454452 no 2648 0.233791902474475 851 5066323 SGTC_1381 2324-0066 62.1 µM -0.726693022898499 0.21079799656957 no 2649 0.233707014249705 848 10885928 SGTC_2444 5485484 36.41 µM -0.727277617757319 0.210612323292252 no 2650 0.233527953220972 870 6790631 SGTC_488 nitrendipine 139 µM -0.727653397269879 0.210493022578431 no 2651 0.233412892384609 843 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1808 st050063 61.5 µM -0.730788768303019 0.209499166828066 no 2652 0.23245409250293 861 4011993 SGTC_1414 3917-0015 5.4 µM -0.735633638303179 0.20796887160463 no 2653 0.230976842736018 847 6618702 SGTC_2108 5365811 200 µM -0.735722319124972 0.207940922623385 no 2654 0.230949851989813 838 780283 SGTC_45 0kpi-0036 14.9 µM -0.735918881048345 0.207878981334541 no 2655 0.230890033009829 846 2795021 SGTC_1659 st012954 42.1 µM -0.736117318836061 0.20781645997011 no 2656 0.230829651931491 847 24207262 SGTC_1342 1486-1464 234 µM -0.738520033717689 0.207060323505109 no 2657 0.230099248870937 851 3253938 SGTC_2339 9000433 200 µM -0.739042150795571 0.206896228348652 no 2658 0.229940701319028 837 2988954 SGTC_306 1672-3436 11.6 µM -0.739603900117303 0.206719763234005 no 2659 0.229770187235186 863 6797378 SGTC_1010 4112-3296 15.2 µM -0.739630932578067 0.206711273640387 no 2660 0.229761983554646 856 704384 SGTC_304 1310-0298 97 µM -0.740644606849085 0.206393076422777 no 2661 0.229454477004236 868 1550234 SGTC_1368 1852-0141 284 µM -0.743533292224535 0.20548789769488 no 2662 0.22857943656961 858 2838987 SGTC_642 0335-0876 158 µM -0.74354554120022 0.205484064465261 no 2663 0.228575730105505 854 6812350 SGTC_1100 amiodarone 5.07 µM -0.744679593373557 0.205129354893925 no 2664 0.228232719221675 830 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2260 7964312 200 µM -0.744940064756694 0.205047935901849 no 2665 0.228153976675116 840 231951 SGTC_1978 st071761 42 µM -0.746545689870394 0.204546468680834 no 2666 0.22766892101947 857 5147680 SGTC_155 k072-0202 43.6 µM -0.748478617085498 0.203943747897489 no 2667 0.227085759024057 851 5857737 SGTC_3310 9130229 44.1445 µM -0.749189524168191 0.203722340997377 no 2668 0.226871491154158 869 7761258 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.751002863905224 0.203158238706566 no 2669 0.226325466112057 851 6708561 SGTC_473 2-arachidonoylglycerol 10 µM -0.752327634402119 0.202746712902992 no 2670 0.225927026628896 838 5282280 An endocannabinoid. SGTC_1190 1486-1332 13 µM -0.752865843648291 0.202579666335129 no 2671 0.225765267567353 850 4150046 SGTC_827 3253-0474 693 µM -0.754053594313851 0.2022113097359 no 2672 0.22540852041728 852 5402065 SGTC_3112 9123419 49.47 µM -0.755493425439023 0.201765313230402 no 2673 0.224976487831465 890 17015854 SGTC_1887 st057648 70.8 µM -0.756867778652447 0.201340148896339 no 2674 0.224564540547 858 688672 SGTC_1807 st050092 58.9 µM -0.759024478442144 0.200674044627828 no 2675 0.223918956972387 856 5008496 SGTC_2090 5301565 104.445 µM -0.761253492091657 0.199986998052435 no 2676 0.22325283673031 864 2056344 SGTC_1653 st012112 65 µM -0.762248178718918 0.199680863753558 no 2677 0.222955948119122 860 720429 SGTC_2770 toltrazuril 17.5 µM -0.76563182863487 0.198641592043906 no 2678 0.221947700203743 825 68591 Kills coccidiodes. SGTC_3182 9108849 49.47 µM -0.76703007522702 0.198213081631236 no 2679 0.221531817122646 848 17133045 SGTC_2148 5546263 113.568 µM -0.767602806902949 0.198037721955473 no 2680 0.221361597154912 867 792097 SGTC_1516 st013856 110 µM -0.768500212353365 0.197763141753184 no 2681 0.221095032276707 861 5281404 A mutagen and neurotoxin. SGTC_2907 7721985 69.9 µM -0.771034019842714 0.196989112352275 no 2682 0.220343383593483 849 3267881 SGTC_2806 7952793 58.44 µM -0.771987564901017 0.196698298244872 no 2683 0.220060896269223 869 2972490 SGTC_1831 st055328 12 µM -0.772341507695246 0.19659041826314 no 2684 0.21995609375828 865 1103068 SGTC_1213 1315-0166 115 µM -0.773284850121232 0.196303067375709 no 2685 0.219676909862908 853 768401 SGTC_1405 3909-7894 12 µM -0.775274265911354 0.195697908084133 no 2686 0.219088806167206 840 7104060 SGTC_755 1995-0008 37.3 µM -0.775752226403373 0.195552686445631 no 2687 0.218947648264389 843 689533 SGTC_355 1311-2252 105 µM -0.776587294650391 0.195299119684049 no 2688 0.218701149948558 879 5338538 SGTC_372 0155-0182 15.9 µM -0.778926836629092 0.194589787102687 no 2689 0.218011407128396 812 771486 SGTC_365 0121-0052 13.6 µM -0.779560923296994 0.194397806881871 no 2690 0.21782468219431 828 3101739 SGTC_2735 sertaconazole 140 nM -0.780020614817141 0.194258699800141 no 2691 0.217689370590138 901 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_633 0437-0093 97.7 µM -0.780365237133617 0.194154453535288 no 2692 0.217587961772482 864 2831118 SGTC_1078 idebenone 36.1 µM -0.781093859734631 0.193934161607606 no 2693 0.217373646525426 873 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1192 1488-0095 21.4 µM -0.78158117570912 0.193786911422685 no 2694 0.21723037665814 888 915875 SGTC_730 1436-0052 41.2 µM -0.782596311969945 0.193480390982863 no 2695 0.216932103955349 829 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_294 k038-0071 157 µM -0.783720735537605 0.193141216686404 no 2696 0.216601996372889 872 24152826 SGTC_1782 st039423 80.636 µM -0.784384031439707 0.192941308560337 no 2697 0.216407402713162 869 2068169 SGTC_370 0180-0345 38.7 µM -0.787222876724028 0.192087148937431 no 2698 0.215575703824562 851 3989527 SGTC_2683 piperine 63.03 µM -0.789330871169953 0.19145438914619 no 2699 0.214959323947755 876 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1773 st048542 73.5835 µM -0.791671592621861 0.190753269749047 no 2700 0.214276095175215 866 3237138 SGTC_1925 st057770 10.1 µM -0.792585908751706 0.19047983190486 no 2701 0.214009560629742 876 5989122 SGTC_2237 6667747 47.222 µM -0.793317806559839 0.190261122108197 no 2702 0.213796342434525 883 729940 YDL015C TSC13 SGTC_1493 4348-0038 111 µM -0.793473188740662 0.190214709796019 no 2703 0.213751092056538 883 800424 SGTC_3356 9151811 4.48 µM -0.794339846960088 0.189955968529057 no 2704 0.213498806308938 876 1859254 YPR165W RHO1 SGTC_2949 9072542 2.23 µM -0.794892550885605 0.189791071525188 no 2705 0.213338003878457 895 16457352 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.795216201137109 0.18969455264599 no 2706 0.213243874594661 833 6708630 An antioxidant. SGTC_2814 7977482 42.97 µM -0.795271562547554 0.189678045807409 no 2707 0.213227775905669 860 6456762 SGTC_2990 9074105 71.4286 µM -0.795521900652952 0.189603414760869 no 2708 0.213154988283815 886 6502001 SGTC_2732 terfenadine 20 µM -0.796216196962436 0.189396524996931 no 2709 0.21295319243916 886 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2849 9019321 12.99 µM -0.796456454630863 0.189324964229662 no 2710 0.21288338799624 874 16489627 SGTC_1986 st071812 45 µM -0.797516966734339 0.189009289530561 no 2711 0.212575426510724 872 11838594 SGTC_1311 1190-0148 100 µM -0.798139314079363 0.188824191106975 no 2712 0.21239482464719 886 1961333 SGTC_960 1222-0186 7.7 µM -0.798407457112192 0.188744474503954 no 2713 0.212317038620512 881 3126296 SGTC_814 3342-0569 96 µM -0.801556802450192 0.187809754534325 no 2714 0.21140468697221 871 4346283 SGTC_3319 9138450 16.7555 µM -0.80259550674884 0.187502096991539 no 2715 0.211104283126856 863 2029690 SGTC_97 0535-0701 19.132 µM -0.803206711145535 0.187321207817774 no 2716 0.210927633582002 858 2832013 YGL099W LSG1 SGTC_2216 7189485 200 µM -0.803259371405088 0.187305627785223 no 2717 0.21091241783482 843 731273 SGTC_12 0849-0099 9.267 µM -0.80402166201161 0.187080186693415 no 2718 0.210692232356475 872 6071388 SGTC_653 0203-0016 55.2 µM -0.806072409744505 0.186474528751314 no 2719 0.210100549489586 878 295302 SGTC_579 4491-1009 110 µM -0.806520310479365 0.186342409672371 no 2720 0.209971450923912 902 1271041 SGTC_2163 5671233 125 µM -0.806599718906825 0.186318992303237 no 2721 0.209948567874412 860 701023 SGTC_2857 9024691 58.44 µM -0.807072284480697 0.186179671477897 no 2722 0.209812419427112 891 16478292 SGTC_3166 9102297 49.47 µM -0.807876393454545 0.185942754145253 no 2723 0.209580871043313 866 25237072 SGTC_1525 8-methoxypsoralen 92.5 µM -0.808718770630708 0.185694762316476 no 2724 0.209338464358214 880 4114 Related to psoralen; DNA damaging agent. SGTC_2913 7966556 36.57 µM -0.810540773869345 0.185159075537851 no 2725 0.208814720318881 845 2976516 SGTC_1583 clindamycin 39.6 µM -0.812098364006924 0.18470189060093 no 2726 0.208367595929014 890 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1719 st032227 49.2 µM -0.812455629329866 0.184597124869238 no 2727 0.208265118434107 873 3125804 SGTC_221 trifluoperazine 10.304 µM -0.813474982570848 0.184298409349474 no 2728 0.207972892051301 893 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_608 k048-0125 159 µM -0.814420179183982 0.184021693915492 no 2729 0.207702141185381 865 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2257 7960413 200 µM -0.815154438525929 0.183806911030293 no 2730 0.207491956925707 855 2974689 YIL048W NEO1 SGTC_2198 6589944 200 µM -0.816255192352342 0.183485215155369 no 2731 0.207177097964061 865 5290268 SGTC_1704 st028805 70.8 µM -0.818301584743393 0.182888089290075 no 2732 0.206592500719514 879 2876101 SGTC_1643 st009866 20.2 µM -0.819170513764722 0.182634907895816 no 2733 0.206344567721438 850 3156273 YOR207C RET1 SGTC_1700 st030840 7.9285 µM -0.820456224793537 0.182260689713171 no 2734 0.205978037257874 884 5499307 SGTC_3311 9131146 2.8755 µM -0.824023545703531 0.18122489927585 no 2735 0.204963089694682 876 4900406 YPR165W RHO1 SGTC_1682 st012968 530 nM -0.824326502727447 0.181137104272007 no 2736 0.204877031806304 873 24207270 SGTC_1919 st067113 52.3 µM -0.825587319400265 0.180772013919634 no 2737 0.20451911540755 888 1268243 SGTC_59 0330-0160 1.33 µM -0.826217026219397 0.180589844736613 no 2738 0.204340495771511 889 4293482 SGTC_1942 st076330 65.2 µM -0.831647551038744 0.179023617907932 no 2739 0.202803956757312 883 24208414 SGTC_2950 9072895 21.46 µM -0.832428980322029 0.178798950051838 no 2740 0.202583424874317 856 17332245 SGTC_999 SEC7.066 22.7 µM -0.83287335776146 0.178671266792722 no 2741 0.202458078390945 889 740511 YDR170C SEC7 SGTC_2476 5806916 10.51 µM -0.83385303489589 0.178389978393425 no 2742 0.202181902649127 867 2870194 SGTC_2895 9054447 58.44 µM -0.834620337772522 0.17816986259845 no 2743 0.201965753722953 897 2697450 SGTC_149 3970-0822 46.1 µM -0.836206739529621 0.177715315460715 no 2744 0.201519303804349 880 3114250 YBL034C STU1 SGTC_1983 st071813 46.9 µM -0.837313117111528 0.17739874172542 no 2745 0.201208294017507 884 11838595 SGTC_736 0958-0254 92.6 µM -0.840416057406921 0.176512781761792 no 2746 0.200337574524455 895 6812352 SGTC_3279 9140807 49.47 µM -0.84056335605977 0.176470794344495 no 2747 0.200296297246798 904 45595718 SGTC_2030 5175110 200 µM -0.841508003516635 0.176201673191795 no 2748 0.200031701614443 901 2831986 SGTC_1155 4088-0394 48.2 µM -0.841744968524712 0.17613420486908 no 2749 0.199965360729024 891 2326248 SGTC_252 miconazole 1.30953 nM -0.842903668518353 0.175804537058606 no 2750 0.199641160835047 866 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_792 4534-1957 155 µM -0.847881871885754 0.174392613118008 no 2751 0.198251880649937 878 1717904 SGTC_1091 telmisartan 47.6 µM -0.850334921217169 0.173699533225792 no 2752 0.197569453339185 905 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2540 epiandrosterone 100 µM -0.850388981655905 0.173684278853299 no 2753 0.197554429978043 892 441302 A steroid. SGTC_113 0099-0221 2.5 µM -0.850717013359278 0.173591735583881 no 2754 0.197463284988969 875 89219 SGTC_354 2783-3500 4.88 µM -0.85261272658346 0.173057537723433 no 2755 0.196937051337405 882 6740761 SGTC_1448 4255-0083 152 µM -0.853665873467316 0.172761221744104 no 2756 0.196645074021253 917 5399660 SGTC_2101 5377231 179.231 µM -0.857301427099165 0.171740800445703 no 2757 0.195639160015734 899 2844213 SGTC_2486 5283202 22.39 µM -0.857346569820994 0.171728154106129 no 2758 0.195626689235649 883 1377751 SGTC_1441 4106-0040 13 µM -0.857410327208971 0.171710294043615 no 2759 0.195609076933706 879 2904180 SGTC_1648 st011736 69.8 µM -0.85795311827628 0.171558292541036 no 2760 0.195459175650435 900 2855514 SGTC_3066 9117245 49.47 µM -0.861042418361459 0.170694812558152 no 2761 0.194607340527335 876 17176980 SGTC_361 000s-0510 1.45 µM -0.86152074524921 0.17056136614026 no 2762 0.194475650241386 892 660 SGTC_3085 9117376 49.47 µM -0.864643291279297 0.169691862026586 no 2763 0.193617301855398 882 16480349 SGTC_1006 4099-6547 255 µM -0.864921436626945 0.169614547824205 no 2764 0.193540955445585 914 3146833 SGTC_429 1112-0049 25.5 µM -0.865827037282099 0.169362980653805 no 2765 0.193292509921106 900 2836170 SGTC_885 0865-0106 16.8 µM -0.866457833270729 0.169187893155711 no 2766 0.193119570286715 882 2793380 SGTC_1460 k062-0059 9.15 µM -0.867939352440638 0.168777131046589 no 2767 0.192713767193104 872 1373085 SGTC_1492 4158-0558 28.5 µM -0.868285052363543 0.1686813754851 no 2768 0.192619151515124 869 3967268 SGTC_2058 5236698 133 µM -0.868755447588288 0.168551136613313 no 2769 0.192490453203313 873 766665 SGTC_7 0192-1582 4.227 µM -0.869699276446007 0.168290012665039 no 2770 0.192232383888939 918 252616 SGTC_1182 1222-0449 220 µM -0.871343873567854 0.167835633098125 no 2771 0.191783210825383 892 658318 SGTC_55 0767-0285 6.563 µM -0.871723864754693 0.167730759195023 no 2772 0.191679518937776 901 3116166 SGTC_866 0495-0101 262 µM -0.87243058490467 0.167535823499703 no 2773 0.191486760675101 880 635694 SGTC_1893 st059353 36.1 µM -0.87265248611389 0.167474646270271 no 2774 0.191426261521188 928 3112488 SGTC_1513 0337-0559 19 µM -0.874947229875177 0.166842839256225 no 2775 0.190801309560177 897 775073 SGTC_2865 9030313 51.95 µM -0.877868467485373 0.166040768625862 no 2776 0.190007551527314 901 42562754 SGTC_1616 st002734 56.1 µM -0.878061215454871 0.165987934473164 no 2777 0.189955249569064 896 4026101 SGTC_2995 9067767 71.4286 µM -0.879180380400959 0.165681374832957 no 2778 0.189651740253452 899 11673567 SGTC_2472 5377652 49.4 µM -0.87985689486961 0.165496242860811 no 2779 0.189468419241384 925 1610903 SGTC_2587 piperic acid 92.2 µM -0.87986934051137 0.165492838295223 no 2780 0.189465047759365 876 5370536 SGTC_1197 1601-0112 267 µM -0.882075117352763 0.164890152948461 no 2781 0.188868093542258 898 7350313 SGTC_3041 9091929 49.47 µM -0.882645657903638 0.1647344955852 no 2782 0.188713875758557 890 25236887 SGTC_1032 k061-1018 98.7 µM -0.882973321681556 0.164645143971117 no 2783 0.188625342951592 923 4005393 SGTC_2314 7727897 200 µM -0.883114103750528 0.164606763334685 no 2784 0.188587312338165 859 900724 SGTC_2922 7999257 32.47 µM -0.883275918595765 0.164562655811019 no 2785 0.18854360580883 919 2988377 SGTC_3189 9110682 49.47 µM -0.885274611436455 0.164018483364094 no 2786 0.188004269824343 912 17122418 SGTC_729 4092-0585 94.1 µM -0.886878810429883 0.163582562962386 no 2787 0.187572075498087 890 2169061 SGTC_2429 5902844 64.44 µM -0.887898944601965 0.163305746313639 no 2788 0.18729755624795 893 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3320 9137005 35.139 µM -0.891440111123175 0.162347202787123 no 2789 0.18634655354851 891 4908713 SGTC_1121 fusaric acid 630.51 nM -0.893666566701773 0.161746411843571 no 2790 0.185750159343199 891 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3063 1327-0034 4 µM -0.896668984277148 0.160938531235649 no 2791 0.184947787760522 881 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2570 licareol 100 µM -0.897535845484108 0.160705769940616 no 2792 0.184716527448249 907 443158 SGTC_2453 5731132 22.18 µM -0.897882649932793 0.160612710919835 no 2793 0.184624057695683 926 1362040 SGTC_1854 st056233 32.9 µM -0.898011435161508 0.160578162578109 no 2794 0.184589726544346 926 5393174 SGTC_2165 5727197 32.143 µM -0.898357788308104 0.160485272847723 no 2795 0.184497416535217 907 1361712 SGTC_3349 9149703 23.001 µM -0.899689227701849 0.16012851612824 no 2796 0.184142828835383 887 4910494 SGTC_2723 salbutamol 83.58 µM -0.900495291384734 0.159912785019163 no 2797 0.183928364989346 889 9884233 β2-adrenoceptor agonist SGTC_1649 st011737 51.3 µM -0.900851082750634 0.159817623184234 no 2798 0.183833751517062 847 1761035 SGTC_2534 helenine 20.12 µM -0.901630393536029 0.159609314078261 no 2799 0.183626619998144 885 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2095 5432005 200 µM -0.901654689617974 0.159602822613892 no 2800 0.183620164727631 920 783734 SGTC_2100 5377183 190 µM -0.902611709839618 0.159347261935998 no 2801 0.183366004769269 881 2844202 SGTC_3007 9078383 71.4286 µM -0.902987232837655 0.159247056297786 no 2802 0.183266335465982 896 6496995 SGTC_1980 st071811 45.7 µM -0.903552955546925 0.159096175154453 no 2803 0.183116248173004 900 4974850 SGTC_1496 4469-0713 57.4 µM -0.904098047046373 0.158950885079999 no 2804 0.182971706932883 912 746691 SGTC_3123 9126162 49.47 µM -0.904626475265842 0.158810119504863 no 2805 0.182831652256536 883 25239884 SGTC_1530 rhein 70.4 µM -0.905398222052427 0.158604684267856 no 2806 0.182627228661704 892 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1258 0671-0043 57.1 µM -0.906054538368799 0.15843011323686 no 2807 0.182453493133861 930 4298767 SGTC_3339 9145883 14.936 µM -0.906374264115763 0.158345116299408 no 2808 0.182368894951346 879 2030670 SGTC_2376 9072922 81.32 µM -0.906483067010055 0.158316198606431 no 2809 0.182340111720944 920 17087968 SGTC_665 3914-0008 307 µM -0.906776925353618 0.158238114092534 no 2810 0.182262387236894 910 1069549 SGTC_373 0844-0104 25.9 µM -0.90692173267393 0.158199644954396 no 2811 0.182224093833463 892 5375804 SGTC_2092 5303694 80.6725 µM -0.907565242963405 0.158028765921835 no 2812 0.18205398233295 903 1963699 SGTC_1715 st032160 10.2275 µM -0.907798049822984 0.157966975773278 no 2813 0.181992464465408 889 5289825 SGTC_573 3702-0553 84.7 µM -0.907921317780133 0.157934265182888 no 2814 0.181959896883839 898 1222756 SGTC_1781 st038725 66.3 µM -0.908089111750854 0.157889746243282 no 2815 0.181915571319061 916 4270275 YIL048W NEO1 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.908641486850151 0.157743248819405 no 2816 0.181769699971916 916 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1975 st070967 30.8 µM -0.908801305689835 0.157700879338077 no 2817 0.181727508627121 898 261391 SGTC_3341 9147222 25.867 µM -0.910866837067016 0.157153960224424 no 2818 0.181182770479966 904 1939759 SGTC_2805 7950783 58.44 µM -0.913175754618574 0.156544074614488 no 2819 0.180575056642756 897 1178958 YDL195W SEC31 SGTC_1057 3448-5381 134 µM -0.913974141156398 0.156333549051813 no 2820 0.180365216769173 871 5497911 SGTC_808 0711-0032 135 µM -0.914391152603444 0.156223661990347 no 2821 0.180255674534239 883 4252555 SGTC_2227 7312221 64.1025 µM -0.918144752509442 0.155236838434597 no 2822 0.179271544019119 921 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1406 3909-7906 11.9 µM -0.919217301091555 0.154955622263976 no 2823 0.178990961745484 887 X1406 SGTC_2903 5923464 63.88 µM -0.919297789093904 0.154934532345 no 2824 0.178969916968947 913 2876576 SGTC_1469 k284-2957 126 µM -0.922705967450809 0.154043242013772 no 2825 0.178080227594073 881 23884841 SGTC_1857 st056007 79.3 µM -0.922859030524219 0.154003293452363 no 2826 0.178040336712037 898 619834 SGTC_839 0122-0028 230 µM -0.922949863565103 0.153979589804438 no 2827 0.178016666715828 907 759448 SGTC_1572 epiandrosterone 68.9 µM -0.924462083648558 0.153585317880766 no 2828 0.177622891907293 903 441302 A steroid. SGTC_1269 0831-0796 3.05 µM -0.927156812364024 0.152884396134249 no 2829 0.176922561192857 883 927758 SGTC_260 nsc-65238 3.989 µM -0.927911047138325 0.152688593806758 no 2830 0.17672685675336 922 3246252 SGTC_108 0509-0257 621.132 µM -0.928945387459273 0.152420345567832 no 2831 0.176458694796472 900 536624 SGTC_1676 st018489 23.4 µM -0.930453662383096 0.152029746918168 no 2832 0.176068122655276 902 3696235 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.931859531909341 0.151666267404802 no 2833 0.175704561900299 904 2333 A French combination drug. SGTC_3256 9138902 49.47 µM -0.935989807747271 0.150601751819571 no 2834 0.174639217715573 927 17228773 SGTC_2229 7354935 190 µM -0.936239613499779 0.150537528173042 no 2835 0.174574915781054 918 318112 SGTC_2197 6588183 93.1375 µM -0.939149975963475 0.149790634900241 no 2836 0.173826874196663 889 884136 SGTC_1049 3226-0134 66 µM -0.940218982344953 0.149516915019929 no 2837 0.17355262343357 908 5702385 SGTC_2288 7946289 167.31 µM -0.943988373537167 0.148554424759648 no 2838 0.172587794793842 935 1246052 SGTC_71 0417-1750 47.813 µM -0.944753294085864 0.148359613889681 no 2839 0.172392420866436 883 6811472 SGTC_2975 9084847 53.72 µM -0.946351583513113 0.147953111416184 no 2840 0.171984645693166 912 27211724 SGTC_1185 1319-0113 81.3 µM -0.947291525803552 0.147714398778928 no 2841 0.17174512389811 919 4672763 SGTC_1106 tegaserod maleate 11.7 µM -0.947804779848786 0.147584159044459 no 2842 0.171614423371185 915 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2340 7987427 183.45 µM -0.94815524853926 0.147495270784664 no 2843 0.171525212778293 901 2239331 SGTC_2155 5570423 76 µM -0.949892628593813 0.147055154316068 no 2844 0.171083406377876 933 797402 SGTC_346 4513-0042 7.16 µM -0.952022482534996 0.146516818234462 no 2845 0.170542789963516 900 2827372 SGTC_1081 sertraline 6 µM -0.952043745091697 0.146511450645835 no 2846 0.170537398453127 911 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3345 9148410 3.559 µM -0.954682260624946 0.145846399598168 no 2847 0.169869201698689 887 4903596 SGTC_1524 corynanthine 62.1 µM -0.957220918090406 0.145208436303225 no 2848 0.169227880522434 949 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1497 4476-2978 41.3 µM -0.961070723842431 0.144244569993197 no 2849 0.16825830435384 902 1528379 SGTC_3059 1327-0034 3 µM -0.961161940255353 0.144221784794521 no 2850 0.168235374860239 902 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1774 st048371 48.465 µM -0.963233641420956 0.143704942198374 no 2851 0.167715143036524 936 4242727 SGTC_3188 9110789 49.47 µM -0.963893380422657 0.143540614946549 no 2852 0.167549691478609 936 849217 SGTC_2557 derrustone 83.84 µM -0.963973191904369 0.143520744171705 no 2853 0.167529683219338 919 629853 An antioxidant. SGTC_981 1488-1094 54.9 µM -0.964022730606286 0.14350841138668 no 2854 0.167517264938437 910 3449522 SGTC_76 0433-0009 400.328 µM -0.964396002930681 0.143415507302415 no 2855 0.167423712711205 973 2841569 SGTC_715 0868-0130 184 µM -0.965918819782358 0.143036912872262 no 2856 0.167042402160618 960 2876258 SGTC_2231 micatex 6.853 µM -0.96839845227143 0.142421886316131 no 2857 0.166422706074046 943 20737 An antifungal of unknown mechanism. SGTC_1896 st058441 89 µM -0.968444009055541 0.142410603565899 no 2858 0.166411334676936 907 688759 SGTC_196 k015-0023 18.111 µM -0.968483447751272 0.142400836530827 no 2859 0.166401490816748 900 5211998 SGTC_2191 5911152 200 µM -0.968502065583046 0.142396225962377 no 2860 0.166396843954642 911 2875902 SGTC_187 1488-2104 32.728 µM -0.968603289454768 0.142371160385665 no 2861 0.166371580750943 904 2852859 SGTC_2132 5317594 122.667 µM -0.968911303813743 0.142294906644007 no 2862 0.166294722523817 929 794577 SGTC_658 3253-0951 102 µM -0.969249766553635 0.14221114680367 no 2863 0.166210293017891 932 1184878 SGTC_618 k072-0232 33.2 µM -0.970270169568153 0.141958828215966 no 2864 0.165955921159224 903 5872756 YGL099W LSG1 SGTC_2273 7815444 169.05 µM -0.971716956850401 0.141601595923412 no 2865 0.165595689284095 932 2824616 SGTC_1367 1812-0510 76.9 µM -0.972362403102533 0.141442422717388 no 2866 0.165435144515224 909 1142582 YDR527W RBA50 SGTC_2514 salinomycin 42.74 µM -0.973210315371076 0.14123350379811 no 2867 0.16522439253596 933 23682228 A polyether potassium ionophore. SGTC_929 2805-0021 398 µM -0.974384599206973 0.140944515139875 no 2868 0.164932806690122 968 3098024 SGTC_1949 st076024 69.1 µM -0.975714644041789 0.140617678796693 no 2869 0.164602946627494 926 2921930 SGTC_1463 k081-0032 34.1 µM -0.978486751596415 0.139938134054868 no 2870 0.163916820324873 880 977755 SGTC_2612 dictamnine 15.46 µM -0.980320511436739 0.139489841007986 no 2871 0.163463966486853 895 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_458 nppb 133 µM -0.980857439663575 0.139358765064633 no 2872 0.16333152399511 942 4549 A chloride channel blocker. SGTC_1691 st019933 84.6 µM -0.982171355270028 0.139038362995823 no 2873 0.163007718446025 951 6176082 SGTC_1880 MG-132 525 µM -0.98252797035041 0.138951487981569 no 2874 0.162919905140697 921 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_972 1319-0219 195 µM -0.982947850760976 0.138849248281034 no 2875 0.162816552741504 929 23903702 SGTC_1657 st012939 43.4 µM -0.985499305282431 0.138229077845655 no 2876 0.162189436254142 896 24207257 SGTC_15 0266-0086 27.098 µM -0.988433627920553 0.137518183494327 no 2877 0.161470162540144 943 1712902 YIL048W NEO1 SGTC_1410 3909-8106 77.9 µM -0.991550489859725 0.136765803619803 no 2878 0.160708425574743 918 1039210 SGTC_966 1300-0360 30.2 µM -0.992069804502067 0.136640720175045 no 2879 0.160581737529336 890 70588 SGTC_1017 4239-0030 168 µM -0.993763291345636 0.13623336621021 no 2880 0.160169060723981 905 1149593 SGTC_2836 9010338 19.48 µM -0.994136114474133 0.13614379848186 no 2881 0.160078302637027 928 2994051 SGTC_1204 4049-0315 18.3 µM -0.995005725369661 0.135935038193842 no 2882 0.159866739880813 940 588402 SGTC_734 2023-0417 80 µM -0.996143518836342 0.135662228670427 no 2883 0.159590208816642 947 3935732 SGTC_513 4245-1575 41.7 µM -0.996993478472958 0.135458678157824 no 2884 0.159383837729451 900 719745 SGTC_578 3460-0051 92 µM -0.997629201005281 0.135306570573873 no 2885 0.15922959790222 954 2876744 SGTC_2079 5212404 121 µM -0.999485635149945 0.134863057009484 no 2886 0.158779747176133 939 758462 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.999738587204934 0.13480270249764 no 2887 0.158718516442612 954 91467 include heat shock SGTC_2795 7780010 54.55 µM -0.999887662338585 0.134767141761866 no 2888 0.158682437883585 929 953673 SGTC_1228 0124-0032 52.5 µM -1.0001020847229 0.134716004226397 no 2889 0.158630553677919 917 X1228 SGTC_1407 3909-7909 12.3 µM -1.00019962943205 0.13469274522269 no 2890 0.158606954274646 904 4411780 SGTC_785 1270-0111 65.3 µM -1.00148869057206 0.134385634460871 no 2891 0.158295302522766 921 6741994 SGTC_293 4049-0273 38.5 µM -1.00272926363137 0.134090530031709 no 2892 0.157995753237494 909 1380311 SGTC_983 1491-0821 12.2 µM -1.00288995891206 0.134052336833442 no 2893 0.157956978931381 922 46495113 SGTC_2138 5575593 77.673 µM -1.00450337991893 0.133669281767078 no 2894 0.157568021456657 931 762213 SGTC_1850 st056238 17 µM -1.0051575585628 0.133514182670559 no 2895 0.157410493995294 915 5393177 SGTC_643 k048-0106 28.4 µM -1.00862558751951 0.132694015917458 no 2896 0.156577115561442 939 6763920 SGTC_2248 tofa 1.1 µM -1.00988141760516 0.132397877734942 no 2897 0.156276053265212 903 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.01228869940972 0.131831489008562 no 2898 0.155700018230826 936 66535 A nucleotide analog. SGTC_447 ml7 120 µM -1.01367188092273 0.131506809290533 no 2899 0.155369672920055 950 4216 Selective myosin light chain kinase inhibitor. SGTC_2122 5258151 111.688 µM -1.01486246870612 0.131227780255237 no 2900 0.15508569544628 941 2173356 SGTC_3343 9148379 18.9835 µM -1.01682780779561 0.130768073729504 no 2901 0.154617675519535 901 1955036 SGTC_1189 1431-2119 7.28 µM -1.0205293606139 0.129905280106878 no 2902 0.153738735946172 931 3107275 SGTC_2247 cerulenin 830 nM -1.02059939882846 0.129888993004783 no 2903 0.153722137208382 905 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1065 prochlorperazine maleate 2.48 µM -1.02300586757109 0.129330237149235 no 2904 0.153152535780588 938 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3161 9100388 49.47 µM -1.02357825665801 0.129197580232314 no 2905 0.153017259781749 939 25236368 SGTC_2078 5212016 200 µM -1.02385357532153 0.129133805976281 no 2906 0.152952220362773 924 1899708 SGTC_1687 st020778 55.3625 µM -1.02438112923426 0.129011665444205 no 2907 0.152827645809757 934 4259299 SGTC_3316 9136639 10.545 µM -1.02502861759924 0.128861866934385 no 2908 0.152674842390604 919 4903665 SGTC_2192 5915882 198.485 µM -1.02504677875273 0.128857667033454 no 2909 0.152670557927639 923 2876149 SGTC_1604 st002052 72.4 µM -1.02534947295112 0.128787680742702 no 2910 0.152599159994737 930 6254834 YHR062C RPP1 SGTC_1667 st014849 34.6 µM -1.02544913091484 0.128764644475908 no 2911 0.152575658040821 932 5348460 SGTC_2673 kobusone 100 µM -1.02548395174197 0.128756596200892 no 2912 0.152567446945385 963 6710676 An epoxy ketone and protein crosslinker. SGTC_2024 5144227 134 µM -1.02972029564821 0.127780036459413 no 2913 0.151570662706383 929 3475211 SGTC_1286 0929-0070 131 µM -1.03263445783449 0.127111261167745 no 2914 0.150887498164639 926 1420408 SGTC_2190 6049624 200 µM -1.03369779752014 0.126867841395443 no 2915 0.150638731534823 916 2265554 SGTC_3148 9097893 49.47 µM -1.03381702693128 0.126840567640118 no 2916 0.15061085504332 904 17174100 SGTC_787 4152-0075 138 µM -1.03406296263191 0.126784322686384 no 2917 0.15055336477811 927 9566539 SGTC_2810 7959871 45.46 µM -1.03564439452051 0.126423067540833 no 2918 0.150184036319302 921 2974535 SGTC_2414 st077232 92.9 µM -1.03570720127763 0.126408735071306 no 2919 0.150169380874098 924 729801 SGTC_810 3825-7150 143 µM -1.03749619522183 0.126000962900418 no 2920 0.149752333995236 906 22330411 YGL099W LSG1 SGTC_786 4544-0069 423 µM -1.03866609257909 0.125734800275747 no 2921 0.149480027967541 926 748821 YLR208W SEC13 SGTC_450 aminopyrene 156 nM -1.03941728962385 0.12556410281747 no 2922 0.149305353222536 932 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1317 1273-0028 910 nM -1.04146927611063 0.125098646273215 no 2923 0.148828902648926 918 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2033 5192550 145 µM -1.04185167289196 0.12501203975926 no 2924 0.14874022641113 903 182073 SGTC_709 3807-1509 243 µM -1.04243146306409 0.124880806828823 no 2925 0.148605842836231 963 1886677 YPL242C IQG1 SGTC_3067 9117431 49.47 µM -1.04261389966136 0.124839533030674 no 2926 0.148563574536204 977 17150885 SGTC_1625 st003711 30.1 µM -1.04576666321095 0.12412776849099 no 2927 0.147834388059811 941 24207034 YER133W GLC7 SGTC_628 1636-0253 16 µM -1.04650478855014 0.123961541070314 no 2928 0.147664017617807 934 4456143 SGTC_1247 0448-0043 5.84 µM -1.04654478145673 0.123952539032588 no 2929 0.147654790409841 950 3089013 YGL099W LSG1 SGTC_1118 chelidonine 707.474 nM -1.04692392092952 0.12386722092999 no 2930 0.14756733411283 934 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_868 0527-0199 213 µM -1.04920689959322 0.12335434911383 no 2931 0.147041451910962 943 2849450 SGTC_1337 1486-1011 40.3 µM -1.04969970466811 0.123243835828793 no 2932 0.146928099793062 924 X1337 SGTC_2556 citropten 84.59 µM -1.05082308705781 0.122992172739987 no 2933 0.146669925121739 930 2775 A potential DNA crosslinker. SGTC_1366 1683-0113 21.9 µM -1.05331105672302 0.122436094309991 no 2934 0.1460992265392 952 708623 SGTC_2721 ifenprodil 61.44 µM -1.05353754277125 0.122385560869692 no 2935 0.146047348610428 954 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1173 0443-0020 122 µM -1.05818057093509 0.121352835757846 no 2936 0.144986563641414 951 5331295 SGTC_855 0428-0020 25 µM -1.06124365480907 0.120674893256999 no 2937 0.144289592418249 938 6812414 SGTC_2980 9014342 25.29 µM -1.06179345413275 0.120553490730293 no 2938 0.144164731059312 923 2996599 SGTC_691 1548-0686 185 µM -1.0631538604651 0.120253465841622 no 2939 0.143856091213866 925 46495133 SGTC_1473 k844-0725 134 µM -1.06459622204765 0.119935941456176 no 2940 0.143529345098522 941 54682906 SGTC_2718 lomofungin 53.02 µM -1.06464639620538 0.119924906663292 no 2941 0.143517987893926 950 5351222 A RNA synthesis inhibitor. SGTC_2645 abamectin 100 µM -1.06536924406552 0.11976601029749 no 2942 0.143354434515162 891 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_673 1082-0474 110 µM -1.06766391357367 0.119262580062871 no 2943 0.142836070982059 941 3098046 SGTC_1148 3909-7663 27.7 µM -1.06797761929533 0.119193872016421 no 2944 0.142765303738854 973 4084526 SGTC_3333 9141820 12.094 µM -1.06799563704885 0.119189926604095 no 2945 0.142761239927353 927 1939433 SGTC_2265 7929201 200 µM -1.06960762919506 0.11883731587564 no 2946 0.142397979841486 939 1265108 SGTC_2103 5378138 10 µM -1.07236392639597 0.118236105577752 no 2947 0.141778302014366 932 244142 SGTC_3171 9103192 49.47 µM -1.07254590748961 0.118196487236839 no 2948 0.141737452926461 967 13018434 SGTC_2147 5545932 89.7195 µM -1.07463562816054 0.117742215637883 no 2949 0.141268947065369 970 797404 SGTC_403 arphamenine a 50 µM -1.07725514142419 0.117174522708333 no 2950 0.140683148445387 954 5487158 An arginine aminopeptidase inhibitor. SGTC_969 1313-0238 134 µM -1.07747289844899 0.117127418514622 no 2951 0.140634526026065 950 5212874 SGTC_1207 2099-0101 141 µM -1.07812343005669 0.116986778432285 no 2952 0.14048933839477 934 5837381 SGTC_562 3772-2733 112 µM -1.07982584895157 0.116619294668884 no 2953 0.140109869075539 943 2876874 YIL048W NEO1 SGTC_1848 st056003 16.4 µM -1.08066469228838 0.116438523487102 no 2954 0.139923147144146 916 146492 SGTC_397 arbidol 50 µM -1.08384677323519 0.11575459079008 no 2955 0.139216371379471 946 131410 A RNA synthesis inhibitor. SGTC_943 3253-1379 105 µM -1.08568150530175 0.11536154643398 no 2956 0.138809962961437 941 668464 SGTC_4 0960-0234 25.671 µM -1.08694189342583 0.115092090744705 no 2957 0.138531245130301 924 6821112 SGTC_2482 5981709 142.65 µM -1.08695933291387 0.115088365535366 no 2958 0.138527391299328 962 877755 SGTC_228 caffeine 993.056 µM -1.0874405033554 0.11498561762739 no 2959 0.13842108960831 945 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1133 3473-0247 50 µM -1.08928698380708 0.114591930482817 no 2960 0.138013675423374 922 711311 SGTC_2222 6885208 172.143 µM -1.09243349769408 0.113923275831883 no 2961 0.137321303045519 969 609514 SGTC_2623 humulene 100 µM -1.09255803583198 0.113896867983511 no 2962 0.137293948028103 964 6187145 An anti-inflammatory. SGTC_2267 7931562 200 µM -1.09326112088466 0.113747863240891 no 2963 0.137139583994513 948 934880 SGTC_1408 3909-7976 48.8 µM -1.09425375430605 0.113537731175966 no 2964 0.136921850842024 946 24152374 SGTC_2688 kanamycin b 96.69 µM -1.0944657830421 0.113492882391986 no 2965 0.136875373188469 927 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2241 6772625 37.8075 µM -1.09464190150066 0.11345563903464 no 2966 0.136836775428653 941 2285411 SGTC_1553 gossypol 38.6 µM -1.09554579291107 0.113264632389722 no 2967 0.13663879752269 921 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_927 2425-1185 123 µM -1.09595309911312 0.113178637121215 no 2968 0.136549649934929 971 730375 SGTC_2696 st077691 74.316 µM -1.09676129293348 0.113008139696517 no 2969 0.136372877393745 965 757133 SGTC_275 trichlorophene 5.69 µM -1.09727343377005 0.112900192853299 no 2970 0.13626094024074 920 62616 SGTC_1937 st074714 47.2 µM -1.09823339231517 0.112698055245925 no 2971 0.136051294260848 955 17250970 SGTC_1661 st013063 9.66 µM -1.09833388935179 0.112676908628744 no 2972 0.13602935942108 968 721395 SGTC_2652 actinonin 100 µM -1.10095580414024 0.112126205529977 no 2973 0.135457946388697 955 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1754 st042065 16.137 µM -1.10137426349597 0.112038491288211 no 2974 0.135366900921726 919 1126236 YIL048W NEO1 SGTC_2566 crystal violet carbinol 226 nM -1.10287685500406 0.111723933936806 no 2975 0.135040323292826 964 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_768 0384-0033 77.3 µM -1.10294897959817 0.111708851047263 no 2976 0.135024661124987 933 3965305 YMR134W ERG29 SGTC_2468 5987765 72.9 µM -1.10476977460707 0.111328563925544 no 2977 0.134629680292829 943 26772094 SGTC_2517 totarol 10 µM -1.1051624475755 0.111246672759656 no 2978 0.134544602713441 941 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3146 9095609 49.47 µM -1.10594535330885 0.111083528055981 no 2979 0.13437508641873 962 17173999 SGTC_2296 7971656 126.45 µM -1.10610458749899 0.111050367243311 no 2980 0.134340626672668 945 666570 SGTC_725 1497-0963 19 µM -1.10889478796247 0.110470453043477 no 2981 0.133737786273276 964 3549977 SGTC_1733 st037357 54.9 µM -1.11003551040048 0.110233992052386 no 2982 0.133491862387923 958 1272339 YGL099W LSG1 SGTC_1546 5-methoxyflavanone 78.7 µM -1.11562237918873 0.109081129337785 no 2983 0.132291904297358 950 147795 SGTC_3307 9126885 69.2785 µM -1.11585837507877 0.109032622528701 no 2984 0.132241380848489 954 24824909 SGTC_224 benfluorex 43.875 µM -1.11622399153528 0.108957504008976 no 2985 0.132163133702353 972 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_504 lovastatin 124 µM -1.12051106583628 0.108079468305055 no 2986 0.131248019844494 970 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3303 9125618 40.5795 µM -1.12312340822344 0.107546938581812 no 2987 0.130692542875746 938 22695467 SGTC_1254 0550-0035 264 µM -1.12980661609193 0.106193169855642 no 2988 0.129278859887135 969 15121435 SGTC_2943 9068529 45.32 µM -1.13050023798419 0.106053376156002 no 2989 0.129132749110771 956 3270634 SGTC_1934 st074720 32.6 µM -1.13296855921094 0.105556985185533 no 2990 0.128613728447051 946 17250992 SGTC_317 4495-0002 170 µM -1.1338064705932 0.105388859868522 no 2991 0.128437868101047 953 15991618 SGTC_1953 st076800 12.1 µM -1.1386450260154 0.104421800966104 no 2992 0.127425620217787 937 297591 SGTC_2017 5132927 60.65 µM -1.13871250684964 0.104408359510059 no 2993 0.127411542258254 972 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2067 5224629 34.075 µM -1.1387303342086 0.104404808701358 no 2994 0.12740782326676 961 2835000 SGTC_2733 amorolfine 100 µM -1.13946751092966 0.104258056300982 no 2995 0.127254105852628 1006 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1042 0350-0096 82 µM -1.13995402793091 0.104161285558137 no 2996 0.127152727153854 965 3122515 SGTC_1195 1502-0147 41.1 µM -1.14158053251045 0.103838238155674 no 2997 0.126814209898263 941 817940 SGTC_541 4513-1321 94 µM -1.14323569144512 0.1035102462559 no 2998 0.126470373598716 938 747515 SGTC_3158 9100007 49.47 µM -1.1468686664733 0.102792961444541 no 2999 0.125717952190526 978 19297233 SGTC_2418 pentamidine 31.67 µM -1.14745047387758 0.102678427308616 no 3000 0.125597745413229 907 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3280 9140961 49.47 µM -1.1475581025325 0.102657249788821 no 3001 0.125575517133428 984 4901226 SGTC_1600 coumarin 106 71.1 µM -1.14825003886074 0.102521176956302 no 3002 0.125432678788531 965 100336 A hepatotoxic, DNA x-linker. SGTC_1788 fluconazole 20 µM -1.14883058460672 0.102407110856317 no 3003 0.12531292263159 943 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3221 9128209 49.47 µM -1.15248888570684 0.10169044741034 no 3004 0.12456011714781 965 16460723 SGTC_272 doxorubicin 8.13 µM -1.15261287133629 0.101666222687131 no 3005 0.124534658884697 970 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1015 4130-4525 82 µM -1.15269006069243 0.101651143297286 no 3006 0.124518811248719 959 1363237 SGTC_3344 9148862 3.898 µM -1.15355391109773 0.101482496179847 no 3007 0.124341551541134 990 4905352 SGTC_3032 9089427 49.47 µM -1.15655457767378 0.100898267868898 no 3008 0.123727194552807 915 17173707 SGTC_87 0100-0052 35.5 µM -1.15663150090574 0.100883323258021 no 3009 0.123711473265482 992 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.15681884174091 0.100846933516576 no 3010 0.123673191085544 1001 4620898 SGTC_602 3130-1533 38.1 µM -1.15880855741621 0.100461034665784 no 3011 0.123267114298537 983 720941 SGTC_2504 purpurogallin 52.29 µM -1.15944941541321 0.100336972048496 no 3012 0.123136522114569 958 5281571 An antioxidant. SGTC_970 1315-0089 19.5 µM -1.16105085040873 0.100027441838975 no 3013 0.122810610345793 953 6811083 YLR033W RSC58 SGTC_1070 indatraline 8.81 µM -1.1611914424028 0.100000301122039 no 3014 0.122782027053965 958 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_345 1362-0200 395 µM -1.16170484833897 0.0999012358530617 no 3015 0.12267768782538 990 1419823 SGTC_783 0848-0141 92.7 µM -1.16336894630877 0.0995806292098985 no 3016 0.122339921610486 954 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2319 6033012 152.6 µM -1.16372856412023 0.0995114438218101 no 3017 0.122267014917267 973 847246 SGTC_376 3970-0862 59.1 µM -1.16627727763752 0.0990221139086514 no 3018 0.121751178513378 961 3135186 SGTC_3326 9140064 16.379 µM -1.1679808831117 0.0986960199685069 no 3019 0.121407238068576 990 1868434 SGTC_39 0986-0283 58.349 µM -1.1693379448326 0.0984368222995086 no 3020 0.121133750484589 943 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1966 st070145 16.1 µM -1.17055140536202 0.0982054747622024 no 3021 0.120889569982019 975 3748532 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.17421030075428 0.0975103139096298 no 3022 0.120155400562456 948 3256 An antibiotic and ribosome inhibitor. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.17693034426512 0.0969958709870223 no 3023 0.119611654713235 955 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2801 7907800 81.82 µM -1.1788121327379 0.096641135370271 no 3024 0.119236496021044 956 6620925 SGTC_1929 genistein trimethyl ether 50.5 µM -1.18358893677466 0.095744942323439 no 3025 0.118287910944519 938 136420 SGTC_1915 st067105 30.6 µM -1.19049669357783 0.0944597894200747 no 3026 0.116925614398824 960 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1612 st002233 45.4 µM -1.19110022362846 0.0943481128264134 no 3027 0.116807121051076 953 1035021 SGTC_181 1447-1644 8.07 µM -1.19167235010568 0.0942423370485836 no 3028 0.116694871905903 996 534600 SGTC_2359 9039622 200 µM -1.19232596534858 0.0941216025565216 no 3029 0.116566728583602 982 6463596 SGTC_3325 9138760 55.175 µM -1.19839153640917 0.0930066214004543 no 3030 0.115382312913821 949 43844959 SGTC_820 1582-0060 59.9 µM -1.20075156049738 0.0925754473843359 no 3031 0.114923793458392 969 3848840 SGTC_1958 st076513 41.9 µM -1.2028802170571 0.0921878139248744 no 3032 0.114511338432369 981 732122 YGL099W LSG1 SGTC_911 3456-4043 236 µM -1.20451597854164 0.091890755212024 no 3033 0.114195104991998 971 914281 SGTC_3220 9131269 49.47 µM -1.20750959186167 0.0913489438948543 no 3034 0.113617976678341 983 17722206 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.20876595019033 0.091122263627849 no 3035 0.113376388228012 964 688664 SGTC_3290 9121031 71.43 µM -1.21415779365536 0.0901541681831096 no 3036 0.112343737063005 956 17014854 SGTC_2824 7998404 51.95 µM -1.21570766190999 0.0898773110741576 no 3037 0.112048152206756 985 837851 SGTC_3121 9125696 49.47 µM -1.21790992031608 0.0894850033357388 no 3038 0.111629102976408 1010 1235365 SGTC_2293 7624732 200 µM -1.2208837952871 0.0889572637316595 no 3039 0.111065010398489 954 894453 SGTC_1369 1866-0067 208 µM -1.22316845876134 0.0885534069227732 no 3040 0.110633038013327 966 3531355 SGTC_2728 chlorpromazine 9.18 µM -1.22386350374434 0.0884308161530244 no 3041 0.110501861694191 1011 2726 A thorazine and dopamine antagonist. SGTC_2607 solasodine 47.35 µM -1.22525386554569 0.0881859662221101 no 3042 0.110239792438913 976 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1964 st076914 61 µM -1.23358384900077 0.0867295874632983 no 3043 0.108679007201042 989 24208661 SGTC_2653 dihydrofissinolide 100 µM -1.2349504770791 0.0864923783322134 no 3044 0.108424467830688 989 6857746 SGTC_1162 k048-0130 20.1 µM -1.23785867028621 0.0859892106374355 no 3045 0.107884234686704 972 6797406 SGTC_2477 5967686 25.23 µM -1.24115324270965 0.0854218424443426 no 3046 0.107274571973832 1000 776118 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.24293422099474 0.0851163047637747 no 3047 0.106946036994817 951 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2878 9043973 25.97 µM -1.24648145906165 0.0845101956881439 no 3048 0.106293845957119 1007 6465167 SGTC_944 3370-0224 231 µM -1.24674545472072 0.0844652170929647 no 3049 0.106245423118582 978 4580514 SGTC_1324 1418-0026 34.4 µM -1.24700783282635 0.0844205318882737 no 3050 0.106197312765213 992 1372513 SGTC_990 3985-0011 41.3 µM -1.25335027606809 0.0833457498114266 no 3051 0.105039129484837 972 5399565 YGL099W LSG1 SGTC_2105 5350118 200 µM -1.25393635019115 0.0832469559873021 no 3052 0.104932570682422 982 2133313 SGTC_3145 9085516 49.47 µM -1.25471036588918 0.0831166160294112 no 3053 0.104791960683503 1002 25236195 SGTC_1199 1638-0010 4.46 µM -1.25513484901939 0.083045200611207 no 3054 0.104714905767664 964 3111136 SGTC_2769 toremifene 3.73 µM -1.25641845524957 0.0828295263417358 no 3055 0.104482146957183 988 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1411 3909-8223 150 µM -1.25651336292781 0.0828135964976422 no 3056 0.104464952057878 989 X1411 SGTC_2036 5160441 105 µM -1.25931556122822 0.0823442977465371 no 3057 0.103958187376884 962 134534 YIL048W NEO1 SGTC_2961 9083290 32.55 µM -1.25952114933261 0.0823099458498905 no 3058 0.103921078031135 989 17741490 SGTC_223 busulfan 5 mM -1.26182050298661 0.0819264798514531 no 3059 0.103506691382007 972 2478 A DNA alkylator. SGTC_2330 7979373 200 µM -1.26521608960866 0.0813626579013942 no 3060 0.102896938157163 972 1863007 SGTC_1261 0712-0010 12.7 µM -1.26551974047572 0.0813123809586506 no 3061 0.102842538270705 990 2840123 SGTC_624 k048-0052 28 µM -1.26568142442725 0.0812856197286203 no 3062 0.1028135806744 991 6835531 SGTC_1097 itavastatin 7.23 µM -1.26775226686081 0.0809434501364027 no 3063 0.102443216577482 972 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_229 benomyl 22.8748 µM -1.26824380066331 0.080862392877936 no 3064 0.102355449831857 976 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_804 1595-0054 20.9 µM -1.26855272907315 0.0808114798575447 no 3065 0.10230031652814 999 761523 Stimulates phospholipase C. SGTC_1956 st077085 54 µM -1.26867777645062 0.0807908782772808 no 3066 0.102278005929905 988 24208685 SGTC_1404 3909-7820 48.3 µM -1.26895225856283 0.0807456712007848 no 3067 0.102229046020481 939 23741373 SGTC_1068 loratadine 26.9 µM -1.26947533105333 0.0806595742927341 no 3068 0.102135791763857 1008 3957 A H1 histamine antagonist. SGTC_796 1234-0020 70.7 µM -1.27133202943952 0.0803545244516586 no 3069 0.10180527614124 950 46495034 SGTC_121 0557-0495 61.343 µM -1.2720422854544 0.0802380623736877 no 3070 0.101679047754933 1010 3104427 SGTC_384 k007-0144 5.16 µM -1.27651233593115 0.0795080255797703 no 3071 0.100887234453321 997 6824886 SGTC_227 fluconazole 33.516 µM -1.27668655833899 0.0794796741470051 no 3072 0.100856464425843 980 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2435 5706476 10.6 µM -1.27708404580361 0.0794150191497801 no 3073 0.100786288393601 966 5725375 SGTC_635 k038-0028 24.7 µM -1.27738462333679 0.0793661538840866 no 3074 0.100733245365716 1000 4035102 SGTC_2775 cyproheptadine 69.59 µM -1.27742551468148 0.0793595078860921 no 3075 0.100726030828623 977 2913 A selective serotonin reuptake inhibitor. SGTC_256 clotrimazole 625 nM -1.27908207596105 0.0790906239759548 no 3076 0.100434077378811 962 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2021 4019055 173 µM -1.28237354062265 0.0785584196120608 no 3077 0.0998558207139632 992 44827708 YER133W GLC7 SGTC_1749 st037932 54.2 µM -1.28342550772434 0.0783888983718691 no 3078 0.0996715210534453 1002 594497 SGTC_1613 st002381 52.1 µM -1.28443199968278 0.0782269650858413 no 3079 0.0994954211922497 974 551167 SGTC_2301 7769476 200 µM -1.28711849498066 0.0777959805058402 no 3080 0.099026494978272 979 977820 SGTC_2294 7971431 200 µM -1.29047956382301 0.0772593173302307 no 3081 0.0984421014421841 1013 5741572 SGTC_2588 indole-3-carbinol 100 µM -1.29735540071167 0.0761702181308582 no 3082 0.0972544652543136 983 3712 Induces cell cycle arrest. SGTC_298 1391-0729 10 µM -1.29898893711091 0.07591320003862 no 3083 0.0969738628975408 994 3237558 SGTC_2755 lomerizine 42.69 µM -1.30092414393617 0.0756095728049329 no 3084 0.0966422104562417 974 3949 A calcium channel blocker. SGTC_448 monastrol 171 µM -1.30121294995453 0.0755643395987843 no 3085 0.0965927869061419 1005 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_591 4299-0174 154 µM -1.3015453221502 0.0755123085188844 no 3086 0.0965359308322936 1022 5509088 SGTC_761 k216-0224 480 µM -1.30288322058256 0.0753031438099049 no 3087 0.0963073166378927 1025 1340404 SGTC_1852 st056254 31.4 µM -1.30369784399587 0.0751760035071784 no 3088 0.0961683124144382 986 442583 SGTC_1491 4138-0063 26.5 µM -1.30371446473401 0.0751734111720535 no 3089 0.0961654778513853 1003 23883227 SGTC_2251 lansoprazole 556 µM -1.30893516525673 0.0743625073343581 no 3090 0.0952781567903899 1002 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_312 4092-0653 6.84 µM -1.3094261313017 0.0742865930898256 no 3091 0.095195022316873 969 1148278 SGTC_2777 climbazole 1.536 µM -1.31568700229385 0.0733237058324662 no 3092 0.0941395592586642 1005 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1239 0337-0584 35.4 µM -1.31769298830266 0.0730172243535571 no 3093 0.093803221357863 1001 914301 YML130C ERO1 SGTC_1002 4049-0206 172 µM -1.3183290947567 0.0729202428354509 no 3094 0.0936967526779779 980 4662749 SGTC_2385 9074692 200 µM -1.32056998803707 0.0725793790887913 no 3095 0.0933223926683846 1004 17046906 SGTC_1895 st058434 18.3 µM -1.32068451535426 0.0725619910991207 no 3096 0.0933032896439308 1018 5393175 SGTC_1947 st076332 61.6 µM -1.32320942481519 0.072179459448947 no 3097 0.0928828713079888 996 24208416 SGTC_1906 st060206 94.7 µM -1.32669955469265 0.0716532412813958 no 3098 0.0923040441707744 979 5133468 SGTC_552 k242-0005 476 µM -1.33264298267233 0.0707639116493649 no 3099 0.0913244963060466 1012 4088318 SGTC_821 1114-0266 29.2 µM -1.33432446091825 0.070513853455718 no 3100 0.0910487722043785 990 3123235 SGTC_670 4204-0025 119 µM -1.33520262384178 0.0703835292306916 no 3101 0.090905019172123 1001 719039 SGTC_1624 st003710 6.25 µM -1.33957753926924 0.0697370255475316 no 3102 0.0901913650313348 996 24207033 SGTC_956 1185-0240 191 µM -1.34159341576776 0.0694406718803703 no 3103 0.0898639311134828 1000 1416193 SGTC_2234 tolnaftate 200 µM -1.34184359596895 0.0694039606871821 no 3104 0.0898233566594577 1027 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1685 st024049 53.0905 µM -1.34296949724104 0.0692389320425595 no 3105 0.0896409254868248 989 1941139 SGTC_309 k408-0051 1.48 µM -1.34512290495788 0.0689241392088495 no 3106 0.0892927737611047 971 3640463 SGTC_1378 2093-0007 380 nM -1.34600126617649 0.0687960544570658 no 3107 0.0891510541197202 1009 3618014 SGTC_2639 lactacystin 53 µM -1.34638529356038 0.0687401123499796 no 3108 0.0890891456400181 970 3870 A proteasome inhibitor. SGTC_2956 9076196 2.52 µM -1.34707946561953 0.0686390798090275 no 3109 0.0889773204011228 1016 16423868 SGTC_3184 9108758 49.47 µM -1.35055398303598 0.0681351051753949 no 3110 0.0884191750153674 1009 902885 SGTC_471 1-acyl-paf 4 µM -1.35463116689218 0.067547362477272 no 3111 0.0877675491949128 1000 16759367 SGTC_3258 9138477 49.47 µM -1.35604622557983 0.0673442943232792 no 3112 0.0875422303854053 1033 4970355 SGTC_1717 st033143 58.0435 µM -1.35691630105935 0.0672196685266015 no 3113 0.0874039033434924 1004 674616 SGTC_3249 9135183 49.47 µM -1.35836066311121 0.0670131782340741 no 3114 0.0871746349290728 963 4902779 SGTC_116 0155-0182 31.788 µM -1.36182147410836 0.0665204066639435 no 3115 0.0866271164207462 894 771486 SGTC_2912 7964298 10.93 µM -1.3663601318015 0.0658784217850493 no 3116 0.085912977913519 980 2975850 SGTC_568 1193-0097 7.48 µM -1.36837722282339 0.0655946536720552 no 3117 0.0855970150365679 941 3646150 SGTC_1941 st076221 61.8 µM -1.3698686771573 0.0653854432671087 no 3118 0.0853639494951435 962 2828568 SGTC_2706 st078239 82.5 µM -1.37412862899932 0.0647907380438015 no 3119 0.0847008764773917 1013 15434492 SGTC_2413 inermin 26.06 µM -1.37592110264912 0.0645417609847766 no 3120 0.0844230305429731 984 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2662 daunorubicin 22.37 µM -1.37743641458603 0.0643318623542839 no 3121 0.0841886804910496 967 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2280 7785178 200 µM -1.3812395172112 0.0638073989513912 no 3122 0.0836026640230751 993 2954328 SGTC_2783 7738165 71.43 µM -1.38136214227767 0.0637905439642321 no 3123 0.083583819978314 1004 17201110 SGTC_1092 toremifene 6.32 µM -1.38225076097939 0.0636685055421723 no 3124 0.0834473594779129 1022 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2131 toluylene red 5.2905 µM -1.3903223539623 0.062568296533449 no 3125 0.082215506381812 969 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2937 9044753 11.33 µM -1.39294189836721 0.0622144393663521 no 3126 0.0818186805642605 971 6465530 YGL099W LSG1 SGTC_1738 st035555 74 µM -1.39490495447048 0.0619502876520899 no 3127 0.0815222514445917 1002 5331140 SGTC_2957 9076800 11.52 µM -1.39898808751724 0.0614036595100772 no 3128 0.0809082776712487 1017 16459615 SGTC_616 4092-0450 108 µM -1.39946928634491 0.0613394881215273 no 3129 0.0808361511681562 1017 787165 SGTC_326 k292-0812 17.5 µM -1.40022068509883 0.0612393883904652 no 3130 0.0807236217173714 981 3579357 SGTC_197 4544-0043 41.561 µM -1.40024030023911 0.0612367770140649 no 3131 0.0807206857397706 1018 896523 SGTC_3014 9081533 49.47 µM -1.40117726739511 0.0611121392829756 no 3132 0.0805805351924599 1016 21367265 SGTC_460 trequinsin 123 µM -1.40334409134944 0.060824662360247 no 3133 0.0802571280901526 1050 5537 A vasodilator. SGTC_722 3534-0461 190 µM -1.40710565093964 0.060328121133696 no 3134 0.079698031355764 999 658262 SGTC_1277 0873-0036 22 µM -1.41102599115353 0.059814002227776 no 3135 0.0791184751940808 1011 5965735 SGTC_586 0957-0265 8.15 µM -1.41363829868045 0.0594733304311363 no 3136 0.0787340651040639 974 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_435 c-PAF 6.7 µM -1.41495967773412 0.0593015891923933 no 3137 0.0785401594089159 995 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3170 9103054 49.47 µM -1.41610278054516 0.0591533326500992 no 3138 0.0783727070645929 986 16432970 SGTC_1780 st038448 24.544 µM -1.42149767121555 0.0584575536186005 no 3139 0.0775860650533102 1013 728868 YDL195W SEC31 SGTC_995 3931-2021 34.6 µM -1.42324869523717 0.0582331107409405 no 3140 0.0773320369478488 1029 730143 SGTC_2261 9010538 184.68 µM -1.43849620588285 0.0563072183176236 no 3141 0.075146656609797 1020 6457250 SGTC_837 0091-0265 12.5 µM -1.4391765157915 0.0562224737027147 no 3142 0.0750502586639107 1033 759367 SGTC_3036 9090181 49.47 µM -1.44157625479232 0.0559243465735042 no 3143 0.0747109755443496 1031 25236586 SGTC_1664 st014217 9.02 µM -1.44967896233185 0.0549269276189565 no 3144 0.0735740324929838 990 3982782 SGTC_1393 3470-5649 58.2 µM -1.45004573966074 0.05488211319095 no 3145 0.0735228823143264 1009 4108395 SGTC_1712 st032288 53.4 µM -1.45335239982154 0.0544793947663182 no 3146 0.073062967713952 1016 2883011 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.453626098374 0.0544461660072921 no 3147 0.0730249985901134 1014 6708760 SGTC_809 3998-0021 90 µM -1.45660950096711 0.0540850006631148 no 3148 0.0726121017773865 1007 715485 SGTC_2146 5545642 200 µM -1.46106169547514 0.0535495553799479 no 3149 0.0719992554906549 1009 825326 SGTC_748 act1.228 77.9 µM -1.46283260891596 0.0533377466555208 no 3150 0.0717565939493732 1021 4421505 YNR035C ARC35 SGTC_3239 9133757 49.47 µM -1.46835320154622 0.0526817194613019 no 3151 0.0710041532891338 1049 17036923 SGTC_2729 fluphenazine 10.66 µM -1.46837111910054 0.0526796007407297 no 3152 0.0710017210831193 1006 3372 An atypical antipsychotic. SGTC_1777 st045864 34.765 µM -1.47398286458296 0.0520193413571553 no 3153 0.0702431024346014 1041 4691462 SGTC_509 pifithrin 175 µM -1.47698361474394 0.0516689903543849 no 3154 0.0698400147559404 1035 4817 A p53 inhibitor. SGTC_2896 9052656 71.43 µM -1.47771132745412 0.0515843098884951 no 3155 0.0697425305807453 979 6469436 SGTC_932 2857-0803 154 µM -1.484833065428 0.0507613993920803 no 3156 0.0687940252566661 1025 674898 SGTC_1025 k007-0731 70 µM -1.48618485435912 0.0506063882345983 no 3157 0.0686151162646442 1029 6256118 SGTC_2724 maprotiline 69.64 µM -1.48743275926211 0.0504636244938646 no 3158 0.068450275049543 990 4011 A tricyclic antidepressant. SGTC_2178 5812956 200 µM -1.49557178337029 0.0495403532090122 no 3159 0.0673826403733493 1019 5403383 SGTC_2285 7945142 200 µM -1.49660646518322 0.0494239534778895 no 3160 0.0672478434439272 1021 2970608 SGTC_2864 9034755 47.6 µM -1.49683518054862 0.0493982529221044 no 3161 0.0672180748737976 1007 4930451 SGTC_2404 5161160 200 µM -1.50036327496812 0.0490031539407436 no 3162 0.06676016358633 1003 2831543 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.50711836622313 0.0482537217168584 no 3163 0.0658901599454384 1050 442882 SGTC_1889 st059080 5.18 µM -1.51224080551146 0.0476915568281489 no 3164 0.0652363068723258 1023 176925 Isolated from Daphnopsis sellowiana. SGTC_805 3852-0218 479 µM -1.51901474471524 0.0469562147672821 no 3165 0.0643793923021793 1015 6615355 SGTC_1522 st012842 45.6 µM -1.52436962983227 0.0463813756715581 no 3166 0.0637082011241888 969 3491067 YOR116C RPO31 SGTC_2572 astragaloside iv 100 µM -1.52756950366003 0.0460405793533688 no 3167 0.0633097291635554 1019 45006101 An anti-inflammatory agent. SGTC_2240 6690706 185.951 µM -1.52900625353852 0.0458882168847946 no 3168 0.0631314468233519 1019 805876 SGTC_1605 st000082 49.1 µM -1.54111713574445 0.0446199420047022 no 3169 0.0616441400386093 993 1114022 SGTC_769 0302-0231 76 µM -1.54551200405066 0.04416674474293 no 3170 0.0611112338015402 1037 571869 YER009W NTF2 SGTC_81 0411-0046 9.971 µM -1.54646684773195 0.0440687739528356 no 3171 0.0609959303329864 1012 12925265 SGTC_3167 9103034 49.47 µM -1.54655698998417 0.0440595340554181 no 3172 0.0609850538719896 1045 5127859 SGTC_570 0987-0065 62.6 µM -1.55119952804884 0.0435857657124479 no 3173 0.0604269376159019 994 3104428 SGTC_1911 st060208 74.3 µM -1.55346146573878 0.0433564304120427 no 3174 0.0601564641795642 1030 688783 SGTC_470 aa-861 153 µM -1.55624591273725 0.043075457424254 no 3175 0.0598248137485323 1004 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1308 1187-1617 41.4 µM -1.57060353342277 0.0416499225038054 no 3176 0.0581373843599683 1034 2882570 SGTC_2804 7954240 19.48 µM -1.57432499922885 0.0412867309365749 no 3177 0.0577061665656552 1024 828705 SGTC_825 1988-2224 89.6 µM -1.57965924078211 0.0407706241660934 no 3178 0.0570924623088545 1037 1180859 SGTC_2731 amoxapine 43.43 µM -1.57998691766007 0.0407390917034637 no 3179 0.0570549312439569 1066 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1578 josamycin 24.2 µM -1.58284170926685 0.0404652105581138 no 3180 0.0567287737131142 1022 5282165 A P450 substrate. SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.58621342229197 0.0401436647921909 no 3181 0.0563454520112346 1028 5377381 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.5883701147684 0.0399390810173235 no 3182 0.0561013355898683 1046 364106 SGTC_95 0471-0001 561.058 µM -1.59428075282812 0.0393827385603713 no 3183 0.0554365833188404 1027 4015405 SGTC_90 0870-0863 4.608 µM -1.60539736796861 0.0383534672383972 no 3184 0.0542031916415607 1036 1738164 SGTC_109 0132-0036 33.701 µM -1.60708411693908 0.0381992271501833 no 3185 0.0540179584989687 982 67274 A color developer. SGTC_2687 chenodiol 100 µM -1.60736384891161 0.0381736968020635 no 3186 0.0539872877649665 1013 5702181 A cholesterol synthesis inhibitor. SGTC_2367 9070478 135.38 µM -1.61240361583141 0.0377161105653887 no 3187 0.0534370692774542 1023 572802 SGTC_2979 9012552 45.46 µM -1.62151976759858 0.036899787031103 no 3188 0.0524531070201657 1045 17100905 SGTC_1130 3454-2858 15.9 µM -1.62915427452561 0.0362273065484434 no 3189 0.0516401820052243 1028 715628 YIL048W NEO1 SGTC_2595 hexamethylquercetagetin 100 µM -1.63026918021127 0.0361299457244076 no 3190 0.051522309156669 1041 386331 SGTC_3163 9099914 49.47 µM -1.63101577395199 0.0360648681549743 no 3191 0.0514434955824235 1061 16268368 SGTC_529 4076-0302 30.3 µM -1.64195987930993 0.0351218844547528 no 3192 0.0502991595026729 1037 5816522 SGTC_2228 7354201 200 µM -1.64378251869671 0.0349668220218576 no 3193 0.050110566785216 1056 753451 SGTC_592 k241-0073 46.5 µM -1.64513430968221 0.0348521806540509 no 3194 0.0499710582886512 1042 4230158 SGTC_1812 st052057 4.327 µM -1.6479734399642 0.0346124069738425 no 3195 0.0496790607842468 1039 3645418 SGTC_2749 bexarotene 57.39 µM -1.64999339880693 0.0344426411902965 no 3196 0.0494721431078361 1024 82146 An retinoic acid receptor inhibitor. SGTC_1437 4092-1038 11.6 µM -1.65788779515801 0.0337857126922961 no 3197 0.0486700580267413 1043 3977136 SGTC_2012 4023501 200 µM -1.65850966541833 0.0337344050505223 no 3198 0.0486073191394912 1040 3477460 SGTC_329 k048-0121 21.3 µM -1.66299919878953 0.0333658936376666 no 3199 0.0481562979370218 1049 6832902 SGTC_677 0929-0063 136 µM -1.66628971593873 0.0330979106889596 no 3200 0.0478278620333504 1070 1539583 SGTC_2966 9084041 48.03 µM -1.67108380318149 0.0327106516594163 no 3201 0.0473525630531167 1041 17741380 SGTC_2321 7390090 138.78 µM -1.6732141076224 0.0325397718870245 no 3202 0.0471425770408199 1049 649046 SGTC_2752 diclazuril 33.15 µM -1.67511525814956 0.0323878958291716 no 3203 0.046955809906828 1020 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2492 derrusnin 100 µM -1.67640210476024 0.0322854266033741 no 3204 0.0468297284691194 1040 1715307 Part of coumarin class of compounds. SGTC_2428 5615643 7.78 µM -1.68599904842896 0.0315296487060931 no 3205 0.0458979913206723 1028 2253075 SGTC_547 1120-0019 610 nM -1.68978871408095 0.0312352606049516 no 3206 0.0455341918643107 989 3676939 SGTC_3147 9097027 49.47 µM -1.69575257844088 0.0307765833688447 no 3207 0.0449663733029547 1044 25236841 SGTC_1818 st052136 56.3 µM -1.70163893439577 0.0303293493525833 no 3208 0.0444115370922313 1011 674169 SGTC_1067 clotrimazole 1.36 µM -1.70589463522379 0.0300093747933288 no 3209 0.0440138493983239 1029 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2698 st077697 67.5 µM -1.71347163413274 0.0294466107303656 no 3210 0.0433129037606841 1049 3154499 SGTC_1325 1431-0015 227 µM -1.71642191744038 0.0292298683299886 no 3211 0.0430424239576794 1047 1103340 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.73159667768745 0.0281358897091195 no 3212 0.0416726990836278 1065 688801 SGTC_1377 2944-0135 198 µM -1.73637611013073 0.0277984721907511 no 3213 0.0412486767818636 1023 1894137 SGTC_852 0418-0143 439 µM -1.73671003710059 0.0277750242193835 no 3214 0.0412191826044262 996 5369229 SGTC_1180 1193-0155 285 µM -1.73685525302313 0.0277648324655865 no 3215 0.0412063617096269 1060 2921347 SGTC_890 0929-0006 47.2 µM -1.73689956859432 0.0277617228667548 no 3216 0.041202449798608 1044 1378169 SGTC_753 1322-0200 289 µM -1.74012615620213 0.0275360935233855 no 3217 0.0409184341755761 1063 5403907 SGTC_1030 k029-0042 36.7 µM -1.74542068883495 0.0271691699567634 no 3218 0.0404558334891776 1036 6080581 SGTC_682 0kpi-0099 17 µM -1.7541708298974 0.0265717103772324 no 3219 0.0397006199480611 1050 1714895 YML126C ERG13 SGTC_302 1094-0063 18.9 µM -1.75586419510438 0.0264573643067981 no 3220 0.0395557999533456 1045 5440289 SGTC_1800 st050079 29.0735 µM -1.75647191802749 0.0264164276409923 no 3221 0.0395039311541955 1034 3645560 SGTC_2778 tioconazole 65.09 nM -1.76684373576933 0.0257258958589268 no 3222 0.0386272009415894 1018 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2365 9042475 200 µM -1.76688505866717 0.0257231751871712 no 3223 0.0386237398869864 1028 6464479 SGTC_1545 lovastatin 49.4 µM -1.77094041924704 0.0254573420879636 no 3224 0.0382853050151507 1064 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_610 4215-0184 155 µM -1.77375142115395 0.0252744313110087 no 3225 0.0380521383752557 1013 5605015 SGTC_1711 st032263 62.8 µM -1.7742209040807 0.0252439898123707 no 3226 0.038013308886899 1051 3958979 SGTC_2300 7976697 71.57 µM -1.77852696305602 0.0249662133739266 no 3227 0.0376586738022972 1032 2236109 SGTC_3046 9092212 49.47 µM -1.77916510557495 0.0249252667522392 no 3228 0.0376063486834883 1060 25236637 SGTC_1575 cyproterone acetate 48 µM -1.78387014152756 0.0246251014743979 no 3229 0.0372223843588331 1047 9880 An androgen receptor antagonist and liver toxin. SGTC_1223 0764-0573 147 µM -1.79418159771628 0.0239778622543967 no 3230 0.0363920941886192 1043 1609797 SGTC_3070 9117005 49.47 µM -1.7988908024145 0.023687060196034 no 3231 0.0360179778986253 1077 8779016 SGTC_2628 lathosterol 100 µM -1.80268089548633 0.023455174173302 no 3232 0.0357191721096059 1049 6710616 SGTC_327 1273-0057 3.96 µM -1.80554236352697 0.0232813713469073 no 3233 0.0354949262756153 1038 3108138 SGTC_1512 0259-0544 12.2 µM -1.8089891658821 0.023073456393868 no 3234 0.0352263432616021 1034 18476 SGTC_1588 farnesol 29.9 µM -1.81039763275662 0.022988947255415 no 3235 0.0351170730714442 1039 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2993 9054257 71.4286 µM -1.81452949927112 0.0227425347792996 no 3236 0.0347981226960707 1030 6470217 YGL055W OLE1 SGTC_156 3474-0145 5.642 µM -1.82563483888755 0.0220912522094897 no 3237 0.0339526421849224 1039 2265471 SGTC_949 1165-0505 146 µM -1.82866244846109 0.0219164508391245 no 3238 0.0337250956095352 1043 6244267 SGTC_3135 9127742 49.47 µM -1.83130866643717 0.0217646273021562 no 3239 0.0335272424172382 1044 3643468 SGTC_2959 9079155 11 µM -1.84053817566811 0.0212420303875544 no 3240 0.0328446324543655 1055 16189457 SGTC_2008 4012253 172 µM -1.84191331697502 0.0211650824375748 no 3241 0.0327439151823901 1021 603940 SGTC_1386 3228-0095 33.8 µM -1.84352172317785 0.021075381134068 no 3242 0.0326264365074597 1047 870181 SGTC_1619 st003326 88.7 µM -1.8463302574654 0.020919519532937 no 3243 0.0324221334796091 1008 2849032 SGTC_3074 9116018 49.47 µM -1.84818102880854 0.0208173438693534 no 3244 0.0322880794561353 1068 17027303 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.8621257276706 0.0200609997818887 no 3245 0.0312926851704391 1066 5106787 A p450 inhibitor. SGTC_1159 4092-0538 61.2 µM -1.86470576888396 0.0199236475751067 no 3246 0.0311113288569409 1056 717301 SGTC_482 fipronil 114 µM -1.86879061573995 0.0197078169141693 no 3247 0.03082597548756 1070 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1011 4112-3381 17.4 µM -1.86904468664564 0.0196944584155751 no 3248 0.0308082987720729 1049 2877139 SGTC_3033 9090887 49.47 µM -1.87528724595137 0.0193686448890389 no 3249 0.0303766085061854 1043 19325384 SGTC_2038 4100038 30.985 µM -1.87831764975336 0.0192121395914152 no 3250 0.0301688617383972 1023 3596803 SGTC_1907 st060210 83.7 µM -1.8836054590231 0.0189416245464205 no 3251 0.0298091814491271 1051 688793 SGTC_637 1181-0519 7.26 µM -1.89348444510129 0.0184449086024037 no 3252 0.0291467374349048 1037 6252091 YGR060W ERG25 SGTC_510 ag-490 170 µM -1.89848501303755 0.0181977373717343 no 3253 0.0288161100896241 1071 5328779 SGTC_3102 9121669 49.47 µM -1.9283960648363 0.0167774655385369 no 3254 0.0269029404665405 1079 41905072 SGTC_255 tunicamycin 200.472 nM -1.93073505051909 0.0166705137512896 no 3255 0.0267579130053 1035 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2409 alverine citrate 63.97 µM -1.93690333492615 0.0163912583283831 no 3256 0.0263785803649302 1043 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1250 0485-0349 40.2 µM -1.94548163351042 0.0160095599479024 no 3257 0.0258585190610389 1049 6842794 YDL195W SEC31 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.95494417827531 0.0155973783356788 no 3258 0.0252948296755754 1025 688669 SGTC_352 k048-0007 5.11 µM -1.95724719930877 0.015498449476836 no 3259 0.0251592060008833 1050 6811911 SGTC_2364 9055074 200 µM -1.96718135766156 0.0150778651951701 no 3260 0.0245811532172351 1053 6470630 SGTC_1165 k072-0275 30.3 µM -1.97379674066905 0.0148032612553928 no 3261 0.0242024298064518 1059 6153523 YGL055W OLE1 SGTC_3000 9075062 71.4286 µM -1.9751561765658 0.0147473670741781 no 3262 0.0241252136930514 1033 17057871 SGTC_115 0527-0192 112.043 µM -1.98410879187791 0.0143837888437392 no 3263 0.0236218566171764 1070 4233931 SGTC_508 roscovitine 141 µM -1.98644891539138 0.0142900352653202 no 3264 0.0234917498934919 1073 160355 A CDKinase inhibitor. SGTC_1026 k007-1105 30.6 µM -1.98670234745738 0.0142799135419477 no 3265 0.0234776957690413 1063 7066794 SGTC_103 0844-0104 51.839 µM -2.00171800050324 0.0136911288185523 no 3266 0.0226575346594185 1034 5375804 SGTC_1072 oxiconazole 14.9 nM -2.01163545133128 0.0133138403521437 no 3267 0.02212918974158 1046 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3039 9090270 49.47 µM -2.0132718582401 0.0132524577404464 no 3268 0.0220430186153718 1052 17173750 SGTC_795 0685-0265 78 µM -2.02834424103585 0.0126984873938359 no 3269 0.0212625633188805 1062 302754 SGTC_257 daunorubicin 18.5 µM -2.03845715058841 0.0123381307308624 no 3270 0.0207521179127445 1054 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2984 9022109 38.96 µM -2.04460671582034 0.0121233604520546 no 3271 0.0204468234368446 1082 6459207 SGTC_2317 5986382 200 µM -2.04876148499422 0.0119800984549202 no 3272 0.0202427218164649 1069 877883 SGTC_146 3448-8650 53.125 µM -2.05268448757823 0.0118461780207345 no 3273 0.0200515937432092 1073 2891488 YIL048W NEO1 SGTC_445 e6 berbamine 66 µM -2.06424992394465 0.0114588977192549 no 3274 0.0194970131190447 1055 6610268 A calcium/calmodulin antagonist. SGTC_1842 st055362 61.2 µM -2.06581193469594 0.0114074445729969 no 3275 0.0194231203745912 1069 676032 SGTC_2249 haloperidol 116.36 µM -2.07044718812331 0.0112559376884933 no 3276 0.0192052433900084 1044 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.08386116405673 0.0108273051342159 no 3277 0.0185863989060516 1061 23665772 A membrane-active detergent. SGTC_2422 chlorphenesin carbamate 384.24 µM -2.10162569184893 0.0102815654426545 no 3278 0.017793038737238 1060 2724 A muscle relaxant with antifungal properties. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.10348575075236 0.0102258347035068 no 3279 0.0177116647940056 1065 229346 A bile salt which induces apoptosis. SGTC_124 0136-0217 7.121 µM -2.10642452863642 0.0101383205401915 no 3280 0.01758374624576 1054 3976905 SGTC_1029 k015-0030 64.7 µM -2.10705550807322 0.0101196159786318 no 3281 0.0175563841676248 1060 2208316 SGTC_2401 5128683 200 µM -2.13189580303056 0.00940678972176619 no 3282 0.0165077066639775 1068 708373 SGTC_688 0527-0193 473 µM -2.14118301730724 0.00915178532325635 no 3283 0.0161296410068226 1082 4007154 SGTC_145 3737-0113 38.366 µM -2.14877339448425 0.00894788687249963 no 3284 0.0158261837026954 1066 6849351 SGTC_3120 9124077 49.47 µM -2.15115013685359 0.00888486454899335 no 3285 0.0157321756355617 1083 18774327 YGL155W CDC43 SGTC_664 1222-0054 14.9 µM -2.15791099467059 0.00870771401274646 no 3286 0.0154673762560747 1071 6813991 SGTC_1021 4476-0760 85.3 µM -2.16670582175203 0.00848190825824015 no 3287 0.0151286462043712 1077 746768 SGTC_1385 3091-4834 14.1 µM -2.16971278212084 0.00840589255305748 no 3288 0.0150143055629121 1079 4072814 SGTC_2343 7990716 14.84 µM -2.17184364565744 0.0083523871838959 no 3289 0.0149337291683674 1073 6456862 SGTC_2236 dapsone 200 µM -2.17583841959974 0.00825288487372176 no 3290 0.01478367238205 1077 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1384 3089-0840 101 µM -2.18677762272419 0.00798572005845972 no 3291 0.0143793809048521 1066 1069836 SGTC_2345 9052315 157.45 µM -2.21017229079866 0.00743974925825595 no 3292 0.0135466036320422 1060 6469265 SGTC_1849 st056239 19.2 µM -2.2153007785857 0.00732455507833831 no 3293 0.013369713225811 1069 5393181 SGTC_288 1315-0019 35.1 µM -2.21669848927025 0.00729343413122264 no 3294 0.0133218510497729 1052 6811474 SGTC_528 3492-0019 172 µM -2.22329860526686 0.00714804786890265 no 3295 0.0130978357560173 1064 2869262 SGTC_1728 st035614 33.7865 µM -2.30692826452779 0.00551545125128571 no 3296 0.0105294097697254 1069 15945546 SGTC_1564 D-Arginine 115 µM -2.32347216056745 0.00523489475508428 no 3297 0.0100769007613918 1075 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1731 st035964 63 µM -2.33863191736264 0.0049890339589243 no 3298 0.00967724573727652 1071 6739575 SGTC_3211 9128781 49.47 µM -2.34209523501412 0.00493433025261626 no 3299 0.00958791057744519 1054 17194361 SGTC_2424 5537928 59.2 µM -2.34620464107789 0.00487011520851482 no 3300 0.00948284560429951 1060 5382802 SGTC_402 epigallocatechin gallate 10 µM -2.35270328582343 0.00477008459028843 no 3301 0.00931874964232611 1065 65064 An antioxidant. SGTC_2433 5607874 27.82 µM -2.38249929851366 0.00433452142899048 no 3302 0.0085977823720363 1065 2252428 SGTC_1206 3978-0017 132 µM -2.40429445568962 0.0040387974432816 no 3303 0.00810185781087647 1066 3873677 SGTC_2591 skatole 100 µM -2.40618862943789 0.00401397015142927 no 3304 0.00805996950261804 1078 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1679 SEC14.276 6.7 µM -2.42448570080717 0.00378109140565365 no 3305 0.00766504351493711 1065 1005053 YMR079W SEC14 SGTC_2091 4-phenylthiadiazole 200 µM -2.46894993580167 0.00326486488941849 no 3306 0.00677550878081335 1085 270010 SGTC_1494 4358-1428 177 µM -2.47217111810927 0.00323005302799594 no 3307 0.00671476086572926 1084 1564571 SGTC_2703 st077852 53.4 µM -2.50890628130229 0.00285602223517862 no 3308 0.00605528052437915 1076 6281836 SGTC_794 k038-0031 316 µM -2.52287620601999 0.0027243603334547 no 3309 0.00581996847723129 1084 6624242 SGTC_178 4092-0806 87.505 µM -2.5237409488877 0.00271639341364071 no 3310 0.00580567289227227 1062 2169044 SGTC_2398 5228213 48.84 µM -2.57196141852708 0.00230406882664444 no 3311 0.0050562080193053 1080 80771 YMR134W ERG29 SGTC_1033 k072-0102 21.3 µM -2.58893374231064 0.00217301087213787 no 3312 0.004813680833762 1073 5965931 SGTC_531 3788-1495 174 µM -2.60733959133327 0.00203855303870488 no 3313 0.00456244066273091 1081 2896655 SGTC_2757 clomiphene 4.22 µM -2.62241932826812 0.00193407034772456 no 3314 0.0043653967367385 1085 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_331 k048-0133 24.5 µM -2.62863618936071 0.00189243032625956 no 3315 0.0042864010413576 1091 6813582 SGTC_917 harmaline 728.087 nM -2.62969363799887 0.00188542924928785 no 3316 0.00427309228739704 1074 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_612 0302-0167 22.4 µM -2.63701313857231 0.00183761067819222 no 3317 0.0041819796005397 1085 235821 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.63911694836514 0.00182407190398709 no 3318 0.00415611502879102 1064 1377 SGTC_1152 3909-8331 15.9 µM -2.65769027474668 0.00170842346548963 no 3319 0.00393390815148125 1087 16001939 SGTC_315 k915-0449 187 µM -2.66953885003741 0.00163817682720798 no 3320 0.00379777427867388 1076 20970215 YNL149C PGA2 SGTC_2360 9040895 200 µM -2.70374282622462 0.00144989833429609 no 3321 0.00342816656185496 1085 4914414 SGTC_1531 st059297 52.4 µM -2.70542409043234 0.00144117437257522 no 3322 0.00341086187012493 1090 7566702 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -2.72645811776513 0.0013360070902424 no 3323 0.00320090382608336 1090 165521 SGTC_1134 3477-0009 42.5 µM -2.85992611394569 0.000816499213913926 yes 3324 0.00211869860142712 1082 3973534 SGTC_733 4069-0007 56.1 µM -2.87972405962549 0.000757688099866066 yes 3325 0.00199011682700681 1091 5717425 YNL287W SEC21 SGTC_1362 1611-0397 101 µM -2.88539230740497 0.000741583502637821 yes 3326 0.00195463091665278 1090 27816 SGTC_2965 9082772 38.63 µM -2.90862328075983 0.000678820681660212 yes 3327 0.0018151200719255 980 16459634 SGTC_2716 st080858 38.6235 µM -2.91172127858967 0.000670831543991338 yes 3328 0.00179721606702174 1091 5296050 SGTC_2440 5628896 157.78 µM -2.93106062239309 0.000622888464847979 yes 3329 0.00168903426390571 1086 5522048 SGTC_2781 5567276 71.43 µM -2.97085937132486 0.000534022928020496 yes 3330 0.00148483865588451 1083 2853274 SGTC_1347 1493-0251 600 nM -3.03470340307038 0.000415614512128179 yes 3331 0.00120386169436524 1042 3986378 SGTC_173 1273-0061 2.693 µM -3.05885217675587 0.000377561139304147 yes 3332 0.00111093377413672 1070 2847414 YPL266W DIM1 SGTC_3062 9077494 49.47 µM -3.0589073678895 0.000377478001056951 yes 3333 0.00111072913536535 964 16459633 SGTC_1533 dihydroergotamine mesylate 29.4 µM -3.07366563012516 0.000355846665090291 yes 3334 0.00105723138382964 1091 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3219 9131112 49.47 µM -3.1503287964103 0.000260855392930032 yes 3335 0.000815434046319225 1065 17612988 YMR079W SEC14 SGTC_2701 st077767 14.721 µM -3.20823365032297 0.000205403174458746 yes 3336 0.000667764749675869 1083 5721188 SGTC_2704 st078022 71.1 µM -3.21395051854096 0.000200571722926597 yes 3337 0.000654611164227643 1091 54697681 SGTC_3222 9128301 49.47 µM -3.25103952569082 0.000171715790541626 yes 3338 0.000574919354179819 1075 4911358 SGTC_710 3448-4187 58 µM -3.25164129371868 0.000171281350140657 yes 3339 0.000573703646430913 1093 3946412 SGTC_2987 9018338 71.43 µM -3.34831304092604 0.000113406543242604 yes 3340 0.000406525586406034 1090 5055682 SGTC_1745 st081495 74 µM -3.40491141629922 8.86419047363816e-05 yes 3341 0.000330927598427966 1084 13842402 YBL026W LSM2 SGTC_524 r073-0010 27.8 µM -3.49205975972349 6.02231242375049e-05 yes 3342 0.000239655498837917 1091 2772106 SGTC_143 4032-1194 15.74 µM -3.51099779981397 5.53071354672298e-05 yes 3343 0.000223214046646731 1091 1806963 SGTC_1785 bathophenanthroline 24 µM -3.52403827021574 5.21448760630814e-05 yes 3344 0.000212511428546079 1066 72812 An iron chelator. SGTC_1789 tunicamycin 25 nM -3.68898054430843 2.43474199804997e-05 yes 3345 0.00011257721709423 1089 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_455 paf C-16 10 µM -3.79846784796594 1.44333763484179e-05 yes 3346 7.27966555069839e-05 1090 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1518 st038567 90.8 µM -3.84655838804722 1.14214517663427e-05 yes 3347 5.98942971838099e-05 1092 77966 SGTC_2342 7990637 118.86 µM -3.91115058245899 8.30549442957201e-06 yes 3348 4.59287384268969e-05 1094 2033102 YER133W GLC7 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -3.951083392864 6.80423264780196e-06 yes 3349 3.88991037154184e-05 1095 4213774 SGTC_690 glyoxal 20.3 µM -3.9659051565901 6.31592100586275e-06 yes 3350 3.65589674024658e-05 1093 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1161 k007-0610 110 µM -4.12549356893594 2.78727901776307e-06 yes 3351 1.84970260241153e-05 1089 5843850 SGTC_1787 fluconazole 80 µM -4.23491854884023 1.56371259616142e-06 yes 3352 1.14317281288605e-05 1090 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -4.25565442067687 1.39928328284565e-06 yes 3353 1.04219222028054e-05 1092 23847180 SGTC_908 3448-7491 47.7 µM -4.35211515579552 8.29056051671233e-07 yes 3354 6.74152036619903e-06 1086 1203031 SGTC_2651 TUB2.036 5 µM -4.44224407038224 5.03409352569935e-07 yes 3355 4.45127466890333e-06 1090 15992207 YFL037W TUB2 SGTC_2322 7413319 38.22 µM -4.46206896802555 4.50516608718597e-07 yes 3356 4.0586045000716e-06 1093 1840400