SGTCid condition conc unit FSF1|YOR271C.score FSF1|YOR271C.strain.pval FSF1|YOR271C.strain.significant FSF1|YOR271C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1652 st011932 78 µM 6.26576688614157 9.1988531185694e-11 yes 1 1.85497495550979e-10 3 1551076
SGTC_1514 1189-1591 158 µM 4.8488081421145 3.88708581838642e-07 yes 2 6.21027383559726e-07 22 767698 YMR146C TIF34
SGTC_387 norethindrone acetate 66.7 µM 4.4637064588939 2.66403647198723e-06 yes 3 4.02769523811347e-06 4 541197
SGTC_310 1273-0058 1.06 µM 4.38554615415849 3.86767405452511e-06 yes 4 5.78475612111586e-06 219 2734232
SGTC_2390 9097792 176.6 µM 4.17551178819608 1.02241297264923e-05 yes 5 1.4865842814158e-05 12 4497149
SGTC_676 falcarinol 140 µM 4.11374157439532 1.34962126030804e-05 yes 6 1.94648618154328e-05 49 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2201 6605497 169.863 µM 4.04646195369292 1.8184758203654e-05 yes 7 2.59987856554625e-05 7 670741
SGTC_1698 5-fluorocytosine 1.055 µM 3.91205631690912 3.25574972458384e-05 yes 8 4.57567817403878e-05 9 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_373 0844-0104 25.9 µM 3.84094962487445 4.39920202587431e-05 yes 9 6.12796330272589e-05 50 5375804
SGTC_1279 0874-0590 65.2 µM 3.78830808035155 5.47990031913532e-05 yes 10 7.58383470172845e-05 36 3523074
SGTC_1522 st012842 45.6 µM 3.7177202165459 7.32583363151989e-05 yes 11 0.000100514364107194 36 3491067 YOR116C RPO31
SGTC_136 0097-0015 404.482 µM 3.67459030749803 8.72692328292224e-05 yes 12 0.000119115686428166 23 4861337
SGTC_1503 4585-0012 61.3 µM 3.61561075759503 0.000110541847698071 yes 13 0.000149820163362126 25 2922052
SGTC_134 0269-0018 6.916 µM 3.57546130470887 0.00012959165021865 yes 14 0.000174805442909686 152 4378915
SGTC_1444 4112-3581 28 µM 3.54599240250987 0.000145487991817448 yes 15 0.000195568741917709 21 2877249
SGTC_1500 4488-1866 171 µM 3.5422423556476 0.00014763710377878 yes 16 0.000198370390036822 31 2900003
SGTC_1049 3226-0134 66 µM 3.53906141400178 0.000149483339685193 yes 17 0.000200776210496064 46 5702385
SGTC_374 0880-0231 82.3 µM 3.53707329454219 0.000150648212311522 yes 18 0.000202293685144653 36 6833587
SGTC_1642 st009582 77.7 µM 3.44821433569143 0.000212297327011907 yes 19 0.00028215302031334 29 6739311
SGTC_1730 st033808 45.1 µM 3.36673479734576 0.000288830539345904 yes 20 0.000380318995363348 67 1045166
SGTC_2130 NSC 7 2.4545 µM 3.34568812393518 0.000312411234239817 yes 21 0.00041039329601068 58 21448
SGTC_669 0108-0021 26.2 µM 3.28708531346086 0.000387841215802614 yes 22 0.00050615080315657 131 17201
SGTC_1370 2001-0092 44.6 µM 3.28350110793593 0.000392963392483151 yes 23 0.000512631208660892 69 790957
SGTC_1689 st020265 53.493 µM 3.27986364490647 0.000398225819328993 yes 24 0.000519286345347041 32 5758320 YPR016C TIF6
SGTC_411 enrofloxacin 100 µM 3.2021551479219 0.000527514099175535 yes 25 0.000682017555737373 25 71188 A bacterial gyrase inhibitor.
SGTC_3016 9080866 49.47 µM 3.02631151170947 0.000975582581940525 yes 26 0.00123778556655134 61 17066299
SGTC_1324 1418-0026 34.4 µM 3.01273288306996 0.00102176347814347 no 27 0.00129453349143908 45 1372513
SGTC_176 1486-1328 72.834 µM 2.9963098644587 0.00108029482080428 no 28 0.00136634297389994 113 22310231
SGTC_230 MPP+ 141.667 µM 2.98751983926926 0.00111287034423441 no 29 0.00140625519943733 64 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_163 TUB2.036 7.546 µM 2.96281304238388 0.00120931321877393 no 30 0.00152420830565323 191 15992207 YJR013W GPI14
SGTC_2220 6782180 200 µM 2.90297328443833 0.00147541262752521 no 31 0.00184819083863263 28 833803
SGTC_1341 1486-1360 280 µM 2.90177634280656 0.00148124235027356 no 32 0.00185526675581954 77 3976547
SGTC_1693 xanthone 101.9 µM 2.84286180421095 0.00179553137111594 no 33 0.00223552261368713 54 7020 An insecticide.
SGTC_384 k007-0144 5.16 µM 2.83203263646217 0.00185950773379357 no 34 0.00231265637280429 133 6824886
SGTC_584 0986-0246 15.4 µM 2.83087600215872 0.00186646194816845 no 35 0.00232103567533603 65 53315 YDR232W HEM1
SGTC_685 1278-0033 54.9 µM 2.82269696738664 0.00191631657457491 no 36 0.0023810779841825 89 3590572
SGTC_1602 st001878 87.6 µM 2.82184239675663 0.00192159474345275 no 37 0.00238743181402084 65 595405 YLR310C CDC25
SGTC_726 3448-4391 34.2 µM 2.75752466993765 0.00235887896814872 no 38 0.00291204092113778 71 1356692
SGTC_335 4077-0256 27.6 µM 2.70035530408337 0.00282116053131495 no 39 0.00346327297785 85 3121989
SGTC_683 panaxydol 45 µM 2.6802189853529 0.0030025095948926 no 40 0.00367870054766113 99 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1764 st044502 93.5 µM 2.67340938927162 0.00306617347914093 no 41 0.00375422786175668 118 8407
SGTC_2644 guaiazulene 100 µM 2.66025160008549 0.00319264186117926 no 42 0.00390411495632333 39 3515 A coloring agent.
SGTC_1616 st002734 56.1 µM 2.65982803528024 0.00319678990400768 no 43 0.00390902784513659 114 4026101
SGTC_132 0417-1715 25.805 µM 2.65477047095662 0.00324669548989066 no 44 0.00396811943163802 78 6769098
SGTC_1054 3429-0080 167 µM 2.65460075098294 0.00324838229125502 no 45 0.00397011620686507 98 1162877
SGTC_278 4092-0821 23.9 µM 2.64084959255604 0.00338769906922776 no 46 0.00413492119386488 111 877900
SGTC_1621 st003705 32.4 µM 2.63932657478355 0.00340345489246424 no 47 0.00415354570509518 114 24207032
SGTC_405 ebelactone b 50 µM 2.62121134066573 0.0035959732576457 no 48 0.00438089635066172 102 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_185 k048-0037 25.491 µM 2.61611694146552 0.00365184657963117 no 49 0.00444680461745592 63 6827589
SGTC_1492 4158-0558 28.5 µM 2.60202816740928 0.00381044458987969 no 50 0.00463371201445872 98 3967268
SGTC_472 calcifediol 10 µM 2.58705202253602 0.00398577617552773 no 51 0.00484004880700784 50 5283731 A vitamin D metabolite.
SGTC_2941 9056145 11.23 µM 2.5736604672849 0.00414863816602486 no 52 0.00503144855312197 67 2119517
SGTC_179 1273-0063 6.77 µM 2.57161872263606 0.0041739852682445 no 53 0.00506121509899808 94 3108139
SGTC_2766 oltipraz 83.91 µM 2.5675412939207 0.0042250191898587 no 54 0.0051211294758405 112 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_731 3966-0296 387 µM 2.54152835503817 0.00456394282794392 no 55 0.00551844967715823 100 660956
SGTC_431 k089-0097 107 µM 2.52945969988261 0.00472927218209003 no 56 0.00571191461926153 171 5499420
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.51922139826394 0.00487369336111979 no 57 0.00588073382506061 192 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1557 sumaresinolic acid 42.3 µM 2.51709846460824 0.00490412684395532 no 58 0.0059162877999272 115 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1733 st037357 54.9 µM 2.49988089276797 0.00515727311030723 no 59 0.00621175338398823 155 1272339 YGL099W LSG1
SGTC_3071 9117417 49.47 µM 2.4812767548476 0.00544381792696933 no 60 0.00654563429101876 77 45595590 YGL055W OLE1
SGTC_2954 9074818 52.69 µM 2.47888941852163 0.00548159430084357 no 61 0.00658960792149856 128 16648742
SGTC_1350 1495-0454 146 µM 2.47769922736811 0.00550051434040584 no 62 0.00661162810800515 148 1069057
SGTC_2341 7987486 176.74 µM 2.46400832126803 0.00572236279171743 no 63 0.00686964608307305 133 1258686
SGTC_2803 7707263 71.43 µM 2.45457208341005 0.00587985673040548 no 64 0.0070526191000413 127 2199229
SGTC_1761 st044296 37 µM 2.41024530284744 0.00667227929819741 no 65 0.00797089894487711 107 1826700
SGTC_304 1310-0298 97 µM 2.40007657272454 0.00686685883699934 no 66 0.00819582127195786 198 1550234
SGTC_938 3126-1755 342 µM 2.39094374403597 0.0070458704672371 no 67 0.00840256380640897 118 1777771
SGTC_354 2783-3500 4.88 µM 2.37312775550665 0.00740696826187883 no 68 0.00881908097846515 169 6740761
SGTC_652 0437-0092 114 µM 2.3684328230973 0.00750480048605998 no 69 0.0089318120535316 112 3091274
SGTC_710 3448-4187 58 µM 2.36481814123202 0.00758089638129779 no 70 0.00901946322808972 232 3946412
SGTC_1787 fluconazole 80 µM 2.344822572618 0.00801423906887844 no 71 0.00951806797193643 202 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.33974272290015 0.00812773994255459 no 72 0.00964851395869221 167 1273210
SGTC_3328 9140624 29.0385 µM 2.33181255165117 0.00830775091045912 no 73 0.00985527721854486 149 4904392
SGTC_1631 benzylvanillin 81.9 µM 2.32304427502502 0.00851085342363562 no 74 0.0100883870366022 155 75506
SGTC_803 4488-1585 147 µM 2.28895121933015 0.00934254639461833 no 75 0.0110410934040652 133 747204
SGTC_2978 9011784 42.97 µM 2.28814766376556 0.00936297804824068 no 76 0.0110644616629487 209 2994934
SGTC_1352 1496-0991 99 µM 2.28658393234827 0.00940285042920263 no 77 0.011110059985478 139 3000039
SGTC_2430 5571206 200 µM 2.27547884615513 0.0096903071383799 no 78 0.0114386101265077 195 1731771
SGTC_77 0828-0286 12.516 µM 2.26787520715348 0.00989153021251466 no 79 0.0116684069311299 190 745345
SGTC_2231 micatex 6.853 µM 2.25909284029057 0.0101284795383637 no 80 0.0119388052102607 110 20737 An antifungal of unknown mechanism.
SGTC_1097 itavastatin 7.23 µM 2.25885741106671 0.0101348990266567 no 81 0.0119461279716786 175 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_127 0180-0333 59.125 µM 2.25225994749403 0.0103162424719216 no 82 0.0121529248296795 223 771601
SGTC_903 1134-0042 114 µM 2.21871615420252 0.0112826705822623 no 83 0.013253020657428 164 701009
SGTC_2576 guaiol 23.12 µM 2.20868385924485 0.0115865922677078 no 84 0.0135983189390748 178 227829
SGTC_2586 curcumin 80 µM 2.20627737989838 0.0116605433721031 no 85 0.0136822920941018 247 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3149 9097855 49.47 µM 2.20483240845591 0.0117051439375834 no 86 0.0137329284819223 162 25236625 YMR079W SEC14
SGTC_780 0109-0199 192 µM 2.20345687452577 0.0117477387366108 no 87 0.0137812816729496 190 610414
SGTC_165 k038-0023 64.381 µM 2.18282582768279 0.0124029240217877 no 88 0.0145243194503462 269 46368543
SGTC_2292 7671323 168.05 µM 2.18242189752487 0.0124160614359595 no 89 0.0145392048376839 219 937504
SGTC_622 1348-1566 26.3 µM 2.17913738020058 0.0125233351400069 no 90 0.0146607320521742 192 7340407
SGTC_406 estrone 100 µM 2.17894958027791 0.0125294929427486 no 91 0.0146677069897847 140 5870 A steroid.
SGTC_1531 st059297 52.4 µM 2.16429177951873 0.0130182674200164 no 92 0.0152209816165207 177 7566702
SGTC_774 k060-0086 136 µM 2.16407987778942 0.0130254526246736 no 93 0.0152291097714302 205 5911235
SGTC_1066 ketoconazole 628 nM 2.1626335608624 0.0130745862338681 no 94 0.015284687424303 186 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_891 0929-0073 133 µM 2.15884857294057 0.0132039269424164 no 95 0.0154309583638843 161 5603632
SGTC_2274 7947094 46.08 µM 2.1511469750433 0.0134705228679354 no 96 0.0157323003767915 209 2971028
SGTC_987 1497-1013 404 µM 2.13963438374092 0.0138777000021598 no 97 0.0161921628116425 136 1676435
SGTC_1752 st044819 83.042 µM 2.13059627019223 0.0142047548354677 no 98 0.0165612085553214 193 441209 YML126C ERG13
SGTC_2412 st077135 33.4 µM 2.12754273085308 0.0143167412973384 no 99 0.0166875074157023 197 13258915
SGTC_2787 5284540 71.43 µM 2.12685199694462 0.0143421786798616 no 100 0.0167161911981677 199 736958
SGTC_1291 0993-0025 5.79 µM 2.12532017199973 0.0143987294849377 no 101 0.0167799531004907 153 4353356
SGTC_2174 5790901 200 µM 2.11894339620789 0.0146362104963932 no 102 0.017047625444336 215 786020
SGTC_2444 5485484 36.41 µM 2.11187114377571 0.0149035262126359 no 103 0.0173487515244847 229 6790631
SGTC_2361 9034121 116 µM 2.0958981230517 0.0155227581640553 no 104 0.0180456146314373 171 6496917
SGTC_453 enantio-paf c16 10 µM 2.07655756719273 0.0163019820509298 no 105 0.0189212063547067 435 13871343 A lipid and platelet activating factor
SGTC_2237 6667747 47.222 µM 2.06194697781104 0.0169126340612147 no 106 0.01960639213784 169 729940 YDL015C TSC13
SGTC_1168 k815-0004 80.5 µM 2.05333926346856 0.017281471093594 no 107 0.0200198426972424 190 642433
SGTC_1330 1469-0054 61.8 µM 2.05210358012244 0.0173349795478541 no 108 0.0200797985477347 179 7102664
SGTC_2381 9035592 200 µM 2.04617921330068 0.0175934905778137 no 109 0.0203693708480775 193 4749657
SGTC_797 k781-0471 270 µM 2.03879182238599 0.0179204443408891 no 110 0.0207354044102399 206 23738129
SGTC_641 4092-0595 30 µM 2.03749530755388 0.0179783572312288 no 111 0.0208002158506308 214 786260
SGTC_2349 9023730 187.07 µM 2.03366068726625 0.0181505773813016 no 112 0.020992909226134 231 4126287
SGTC_2711 st079103 59.1 µM 2.03259577989526 0.0181986531477929 no 113 0.0210466891108132 159 54693780
SGTC_1935 st074532 41.6 µM 2.02810051013634 0.0184027919770104 no 114 0.021274995436044 259 2829742
SGTC_2650 prasterone 100 µM 2.02777709924829 0.0184175536003111 no 115 0.0212915013245532 117 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_193 1273-0060 1.558 µM 2.02619994398556 0.0184896851685726 no 116 0.0213721496944426 128 2847393 YHR072W ERG7
SGTC_3324 9138759 60.749 µM 2.02184698176568 0.0186900183394403 no 117 0.0215960812131217 197 45595710
SGTC_884 0851-0618 334 µM 2.01929705621093 0.0188082275548691 no 118 0.021728176839626 220 9642473
SGTC_1917 st066507 28.5 µM 2.01765722049596 0.0188845825236491 no 119 0.0218134865404696 263 3156428
SGTC_634 1611-4317 11.2 µM 2.01528006118648 0.0189957372841913 no 120 0.0219376564400046 233 2843522
SGTC_925 2064-1272 59.6 µM 2.00787522879911 0.0193455561716422 no 121 0.0223282760442577 218 6815817
SGTC_455 paf C-16 10 µM 1.98973916860114 0.0202255303704017 no 122 0.0233098377862954 207 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1103 duloxetine 36.1 µM 1.98631424967804 0.0203954641074188 no 123 0.0234992206859836 261 60835 A selective serotonin reuptake inhibitor.
SGTC_2413 inermin 26.06 µM 1.98357459815214 0.0205322667083323 no 124 0.0236516416532368 272 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1655 st012546 55.1 µM 1.98096096894681 0.0206635002841639 no 125 0.0237978254266694 210 720985 YLR208W SEC13
SGTC_510 ag-490 170 µM 1.96466537545968 0.0214978443493692 no 126 0.0247264899615768 161 5328779
SGTC_117 lucigenin 22.078 µM 1.9616596340727 0.0216548102172028 no 127 0.02490106218877 331 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2435 5706476 10.6 µM 1.95985484325574 0.0217495245041078 no 128 0.0250063794522672 262 5725375
SGTC_1012 4112-3522 18 µM 1.95904955404903 0.0217918983476406 no 129 0.0250534918675313 239 3112398
SGTC_1667 st014849 34.6 µM 1.95730846706144 0.021883751721475 no 130 0.0251556063140312 189 5348460
SGTC_1334 1486-0610 236 µM 1.946927316046 0.0224382352221455 no 131 0.0257717246168374 239 3742339
SGTC_1898 st060199 18.6 µM 1.94056034367904 0.0227841382513044 no 132 0.0261558140641729 205 688866
SGTC_103 0844-0104 51.839 µM 1.93528245148162 0.0230742702024061 no 133 0.026477822288121 409 5375804
SGTC_2321 7390090 138.78 µM 1.93492052168144 0.0230942793882833 no 134 0.0265000247431788 226 649046
SGTC_135 0933-0004 26.348 µM 1.93352472375086 0.0231715825577821 no 135 0.0265857952012929 245 21230617 YGL099W LSG1
SGTC_1422 4031-0024 15.5 µM 1.93173357850944 0.0232711001975865 no 136 0.0266961990073534 226 782427
SGTC_2736 butenafine 14.65 µM 1.92810260832635 0.0234739442794207 no 137 0.0269211823123548 276 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1665 st014639 11.4 µM 1.9280451769915 0.023477164592349 no 138 0.0269247535672922 275 981133 YIL048W NEO1
SGTC_2814 7977482 42.97 µM 1.92095603585434 0.0238775342527444 no 139 0.0273686251583309 329 6456762
SGTC_1096 rimcazole 32.2 µM 1.90936435175572 0.024544549722083 no 140 0.0281075530575568 212 18528119 A dopamine reuptake inhibitor.
SGTC_934 2950-0684 338 µM 1.90631392599618 0.0247226556777343 no 141 0.0283047442648739 255 1121253
SGTC_1124 fisetin 1.16336 µM 1.90320926132567 0.0249050405282292 no 142 0.0285066225869378 237 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_558 k064-0027 21.3 µM 1.89996473652809 0.025096845834224 no 143 0.0287188737349584 252 5088526
SGTC_2585 alliin 100 µM 1.88909885891927 0.0257482387882971 no 144 0.0294392916646314 279 87310 A garlic compound which reacts with lipids.
SGTC_233 rapamycin 362 pM 1.88665973218677 0.0258963894419846 no 145 0.0296030535317469 230 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2009 4012297 12.05 µM 1.8860103768615 0.0259359507743882 no 146 0.0296467781638169 283 45595307
SGTC_3265 9137266 49.47 µM 1.88595992251743 0.0259390267713301 no 147 0.0296501777724738 174 17224265
SGTC_1312 1218-2183 165 µM 1.8851403463984 0.0259890357671921 no 148 0.0297054460533984 231 6744073
SGTC_532 1548-0774 215 µM 1.88296751249476 0.0261220084951784 no 149 0.0298523854016529 268 5932993
SGTC_2997 9067075 71.4286 µM 1.88199830823599 0.0261815049316627 no 150 0.0299181226687175 297 27209819
SGTC_769 0302-0231 76 µM 1.86181299686007 0.0274466009088431 no 151 0.0313147269409786 340 571869 YER009W NTF2
SGTC_2384 9036245 200 µM 1.85049261856745 0.0281781345510886 no 152 0.0321212904735645 269 6462766
SGTC_1386 3228-0095 33.8 µM 1.83783682085769 0.0290151077901897 no 153 0.0330432270565951 248 870181
SGTC_904 1141-0088 396 µM 1.833944027961 0.0292766692614538 no 154 0.0333311515544744 262 1378119
SGTC_1630 st005209 31.3 µM 1.83363230517184 0.029297698710904 no 155 0.0333542967275657 319 3367314
SGTC_1614 st002383 48.6 µM 1.8294328064528 0.0295822303281613 no 156 0.0336673983749935 266 1947235
SGTC_2308 7584454 197.62 µM 1.82911720335898 0.0296037059496283 no 157 0.0336910261599135 310 893577
SGTC_169 k015-0017 16.025 µM 1.81399405977493 0.0306480462398766 no 158 0.0348393201513633 246 1840002
SGTC_2994 9053520 71.4286 µM 1.81318071481569 0.0307050661969184 no 159 0.0349019766401431 283 4647384
SGTC_668 1682-0499 62.6 µM 1.81287648698898 0.0307264168019265 no 160 0.0349254367604756 316 682214
SGTC_2335 9018011 154.17 µM 1.81217528860331 0.0307756734837796 no 161 0.0349795580330756 311 6458208
SGTC_1382 3002-2117 298 µM 1.7981886607019 0.0317719189490921 no 162 0.0360735579408021 281 1497314
SGTC_722 3534-0461 190 µM 1.79743589153563 0.0318262844590114 no 163 0.0361332235418883 306 658262
SGTC_1367 1812-0510 76.9 µM 1.797087767809 0.0318514521694458 no 164 0.0361608436590178 283 1142582 YDR527W RBA50
SGTC_189 3970-0742 2.116 µM 1.78595996198802 0.032664642094834 no 165 0.0370528705433523 229 2891807
SGTC_39 0986-0283 58.349 µM 1.78149142158986 0.0329959734064652 no 166 0.0374161025299202 342 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1794 st048918 76.9 µM 1.78065682990882 0.033058162245075 no 167 0.0374842648287993 212 672303
SGTC_118 0083-0097 135.343 µM 1.77969511750173 0.0331299430987782 no 168 0.0375629349756142 556 5207356
SGTC_2697 mebhydrolin 72.4 µM 1.77942098798277 0.033150427239439 no 169 0.0375853840354163 350 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_628 1636-0253 16 µM 1.77342046512851 0.033601432295428 no 170 0.0380795301681909 329 4456143
SGTC_2162 5663267 200 µM 1.77018126065108 0.0338469853724556 no 171 0.0383484750074801 262 6456493
SGTC_2557 derrustone 83.84 µM 1.76608523239918 0.0341596029472111 no 172 0.038690775309753 364 629853 An antioxidant.
SGTC_299 1273-0059 1.44 µM 1.76424678539183 0.0343006869380827 no 173 0.0388452194874671 266 2848077
SGTC_515 4092-1064 102 µM 1.75665354696467 0.0348884811469335 no 174 0.0394884399722976 375 717353
SGTC_593 1203-0218 61.7 µM 1.75498175237083 0.0350189996110163 no 175 0.0396312145255391 290 3666956
SGTC_2216 7189485 200 µM 1.75242839251938 0.0352191158040239 no 176 0.0398500864304794 218 731273
SGTC_1316 1272-0050 65.9 µM 1.74346482966819 0.035929062903894 no 177 0.0406262262908267 267 7340392
SGTC_2420 aureobasidin a 50 nM 1.74341604429437 0.0359329587257007 no 178 0.0406304838657845 364 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2588 indole-3-carbinol 100 µM 1.73038255604865 0.036986228360924 no 179 0.0417809741852718 378 3712 Induces cell cycle arrest.
SGTC_1783 st039459 87.517 µM 1.72502809523775 0.0374261880489275 no 180 0.0422612047255256 356 729761
SGTC_2749 bexarotene 57.39 µM 1.72452331239375 0.0374678840689735 no 181 0.0423067070857855 346 82146 An retinoic acid receptor inhibitor.
SGTC_269 exalamide 29 µM 1.72375592208169 0.0375313446322172 no 182 0.04237595744683 268 3316 A derivative of salicylamide.
SGTC_2236 dapsone 200 µM 1.71279630628318 0.0384472823997959 no 183 0.0433750099579957 313 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1183 1254-0324 198 µM 1.71139469912728 0.0385657232668938 no 184 0.0435041375428378 301 5799357
SGTC_1619 st003326 88.7 µM 1.70936441249593 0.0387378169525219 no 185 0.0436917343364474 277 2849032
SGTC_1758 st042942 75.2445 µM 1.70740636792274 0.0389043792591254 no 186 0.0438732737963543 289 669317
SGTC_1796 st049173 110.4 µM 1.70451525733117 0.0391513793109293 no 187 0.044142434060588 239 94134
SGTC_3343 9148379 18.9835 µM 1.70014691040366 0.0395270060339923 no 188 0.0445516476958829 307 1955036
SGTC_235 0330-0087 5 mM 1.69990075963715 0.0395482590613228 no 189 0.0445747970104544 354 46494818 YHR062C RPP1
SGTC_2439 5492030 7.2 µM 1.69561480261429 0.0399198071299387 no 190 0.0449794263004222 299 5722370
SGTC_382 3229-0966 23.2 µM 1.69431683488499 0.0400328855198264 no 191 0.0451025466181298 338 5722370
SGTC_967 1306-0166 352 µM 1.69001965972836 0.040409112057439 no 192 0.045512096766162 350 4437607
SGTC_3236 9132701 49.47 µM 1.68959929835395 0.0404460692142468 no 193 0.0455523201373417 309 24282524
SGTC_2944 9067346 25.62 µM 1.68339205285652 0.0409949965942117 no 194 0.0461496103496324 361 6473075
SGTC_759 3486-0358 89.3 µM 1.68128579139831 0.0411826276171126 no 195 0.0463537081953748 359 875103
SGTC_1641 st009299 47.1 µM 1.68000583944588 0.0412969886431488 no 196 0.0464780897919595 246 4046054
SGTC_1 0258-0098 57.368 µM 1.67958466607128 0.0413346758426667 no 197 0.0465190765893399 279 6790032 YDR047W HEM12
SGTC_1729 st035615 45.989 µM 1.67813366782362 0.0414647267549481 no 198 0.0466605037219149 338 17385451
SGTC_2085 5307070 144.047 µM 1.67704536156453 0.0415624875477869 no 199 0.0467668059390392 293 2840351
SGTC_318 1488-0629 67.2 µM 1.67652404014298 0.0416093831145872 no 200 0.0468177956978173 302 3662576
SGTC_3345 9148410 3.559 µM 1.67641756795943 0.0416189661092303 no 201 0.0468282150832288 272 4903596
SGTC_2780 5215298 71.43 µM 1.6730364936571 0.0419242096182284 no 202 0.0471600560344212 375 2834131
SGTC_2555 cholic acid 100 µM 1.66755194883286 0.0424232069884417 no 203 0.0477023518843396 318 6708657 Influences liver metabolism.
SGTC_873 0591-4978 488 µM 1.66373145053004 0.0427736357782611 no 204 0.0480830541249673 350 3305145
SGTC_1832 st054113 55 µM 1.66349639782117 0.0427952717710431 no 205 0.0481065556569215 292 1251267
SGTC_942 3253-1115 227 µM 1.66090891590384 0.0430340278862314 no 206 0.0483658706653477 341 46497897
SGTC_1167 k781-0610 148 µM 1.65769372390499 0.0433322031951384 no 207 0.0486896506228167 382 4525169
SGTC_1082 camptothecin 424.86 nM 1.65528707449775 0.0435564845384256 no 208 0.0489331397862135 341 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3119 9125183 49.47 µM 1.647690699986 0.0442705604368946 no 209 0.0497080787131627 221 22695334
SGTC_252 miconazole 1.30953 nM 1.64636128776364 0.0443964928966402 no 210 0.0498446991389829 340 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2139 5578692 56.4705 µM 1.64573821326562 0.0444556147197069 no 211 0.0499088339759667 296 650991 YMR113W FOL3
SGTC_661 1304-0007 33.6 µM 1.64531050156234 0.044496235811609 no 212 0.0499528976468101 334 3117130
SGTC_2545 solidagenone 89.61 µM 1.64521172811501 0.0445056208777872 no 213 0.0499630778830424 175 6708572 An anti ulcer agent
SGTC_1748 st037455 53.6035 µM 1.64316395385764 0.0447005518740294 no 214 0.0501745078229842 366 580690
SGTC_1805 st050013 60.3 µM 1.62895772077556 0.0460718674641695 no 215 0.0516609847654023 305 4037144
SGTC_3260 9137109 49.47 µM 1.62629294156982 0.0463328218349242 no 216 0.0519436763026916 251 17478346
SGTC_314 1671-0008 2.74 µM 1.62544534577974 0.0464160728348353 no 217 0.0520338502127106 414 3913060
SGTC_1704 st028805 70.8 µM 1.62493504343342 0.0464662526992824 no 218 0.0520882001405724 323 2876101
SGTC_1359 1582-0056 520 nM 1.61916776447584 0.0470364021165412 no 219 0.0527055858790739 399 3661189
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.61859844218302 0.0470929878349066 no 220 0.0527668452560412 391 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1207 2099-0101 141 µM 1.61564455948378 0.0473874549924684 no 221 0.0530855919845505 391 5837381
SGTC_3235 9132602 49.47 µM 1.61226522514302 0.0477261421355765 no 222 0.0534521185715605 395 4912240
SGTC_3238 9133470 49.47 µM 1.61154504960949 0.0477985702879411 no 223 0.0535304882732209 315 3534688
SGTC_391 gliotoxin 8.33 µM 1.61135232141181 0.0478179679092134 no 224 0.0535514764429003 396 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_56 0957-0365 83.25 µM 1.60824696756967 0.0481313839257579 no 225 0.0538905501826932 390 6752360
SGTC_735 3076-0345 636 µM 1.60678588622723 0.0482794149761193 no 226 0.0540506726851106 404 2888990
SGTC_1050 3232-1156 69.3 µM 1.60603295118952 0.0483558414902554 no 227 0.0541333350853908 366 700529
SGTC_257 daunorubicin 18.5 µM 1.60530139094183 0.0484301910178121 no 228 0.054213746613374 317 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_869 0564-0080 44.1 µM 1.60512339837047 0.0484482944815621 no 229 0.0542333254627167 405 6843321
SGTC_2881 9058953 51.95 µM 1.60437706049592 0.0485242627616555 no 230 0.0543154821518101 400 17122249
SGTC_2864 9034755 47.6 µM 1.60370860480274 0.0485923843966553 no 231 0.0543891491496183 353 4930451
SGTC_1510 1123-0200 71.5 µM 1.58968056716804 0.0500396848071016 no 232 0.055953413086815 448 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_499 genistein 192 µM 1.58714118676131 0.050305315288107 no 233 0.0562403357504843 274 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2199 6590217 200 µM 1.58217607087028 0.050827934496351 no 234 0.0568046907311626 297 703109
SGTC_941 3237-0776 460 µM 1.58032088401855 0.0510243140054327 no 235 0.0570166997905907 350 760008
SGTC_2744 captopril 92.04 µM 1.57114607745507 0.0520044003870493 no 236 0.0580743609083358 278 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_914 3820-6779 408 µM 1.57053888728793 0.0520697867351342 no 237 0.0581448974198304 377 2893481
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.5675326645714 0.0523944798129827 no 238 0.0584951186505014 411 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2030 5175110 200 µM 1.56714489124604 0.0524364788365843 no 239 0.0585404141196855 372 2831986
SGTC_395 anisomycin 6.25 µM 1.56633092689934 0.0525247247627402 no 240 0.0586355821656673 322 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1656 st012921 11 µM 1.56476482577282 0.0526948451400627 no 241 0.0588190310353458 344 6732821
SGTC_133 0724-0033 378.92 µM 1.55681104452544 0.0535655968885685 no 242 0.0597576771055046 358 280309
SGTC_3014 9081533 49.47 µM 1.55590504044938 0.0536655020205488 no 243 0.0598653373239568 377 21367265
SGTC_1859 st055998 20 µM 1.5552295887117 0.0537400801198666 no 244 0.0599456998815982 416 676301
SGTC_218 alverine citrate 93.75 µM 1.55356262533316 0.05392448444508 no 245 0.0601443900991353 349 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1834 st055981 52.8 µM 1.55258552383761 0.0540328069142342 no 246 0.060261093130417 395 471719 YDL150W RPC53
SGTC_2279 7948423 32.93 µM 1.55242241533588 0.05405090605368 no 247 0.0602805917332746 339 1247112
SGTC_1871 st057448 67.3 µM 1.54966359700229 0.0543577626067555 no 248 0.0606111399160321 407 691747
SGTC_2865 9030313 51.95 µM 1.54604263769049 0.0547626025543142 no 249 0.0610471353914827 363 42562754
SGTC_3082 9117008 49.47 µM 1.54580086900279 0.0547897180674304 no 250 0.0610763335566197 387 41448529
SGTC_656 4090-1979 187 µM 1.5442552482022 0.0549633177073617 no 251 0.0612632546701817 430 22330961
SGTC_479 n-linoleoylglycine 10 µM 1.5375940640094 0.0557164608621476 no 252 0.0620739498809385 342 6433346 An anti-infammatory.
SGTC_2398 5228213 48.84 µM 1.53742812567433 0.0557353260384902 no 253 0.0620942516398637 494 80771 YMR134W ERG29
SGTC_3261 9137475 49.47 µM 1.53511648286317 0.0559986563361035 no 254 0.0623776090963174 204 17027690
SGTC_266 formosanin C 406 nM 1.53460728436713 0.0560567932539666 no 255 0.0624401611390305 430 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2401 5128683 200 µM 1.52992235622422 0.0565939236398357 no 256 0.0630179744450462 370 708373
SGTC_808 0711-0032 135 µM 1.52874032534946 0.0567300829499068 no 257 0.0631644156019171 390 4252555
SGTC_1201 1889-3372 45.9 µM 1.52548607801834 0.0571062762715547 no 258 0.063568951703505 357 5392199
SGTC_1678 st019265 80.2 µM 1.52385950867365 0.0572950434999166 no 259 0.0637719051101422 447 5367020
SGTC_1634 st006576 41 µM 1.5236097718948 0.057324069477225 no 260 0.0638031103280611 398 3915356
SGTC_659 k018-0002 107 µM 1.52117908193413 0.0576071842528733 no 261 0.06410745164543 414 6797879 YHR007C ERG11
SGTC_1254 0550-0035 264 µM 1.5198562130103 0.0577617269569066 no 262 0.0642735587333927 449 15121435
SGTC_1283 0922-0125 16.4 µM 1.51919283763471 0.0578393476769663 no 263 0.0643569818214769 452 3360884
SGTC_1295 1013-0063 9.78 µM 1.51839226986451 0.0579331302722802 no 264 0.0644577696177628 419 6826038
SGTC_3096 9117468 49.47 µM 1.51111566411942 0.0587910387010337 no 265 0.0653794922274107 305 41316311
SGTC_206 4546-0025 72.014 µM 1.50219268227186 0.0598566274066826 no 266 0.0665236770747692 493 6620745 YIL048W NEO1
SGTC_749 1000-0129 128 µM 1.50211072177686 0.0598664848414031 no 267 0.0665342581702342 466 708470
SGTC_3044 9093193 49.47 µM 1.5018456179346 0.0598983777376436 no 268 0.0665684919841265 444 25236277
SGTC_1246 0422-0085 105 µM 1.49751409181251 0.0604213622964626 no 269 0.0671297708233857 465 264295
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.48501228622619 0.0619508705812752 no 270 0.0687702847591236 520 551469
SGTC_473 2-arachidonoylglycerol 10 µM 1.48453427658319 0.0620099459869188 no 271 0.0688336183934246 418 5282280 An endocannabinoid.
SGTC_1499 4480-0877 67.3 µM 1.48399375452314 0.0620768000124236 no 272 0.0689052887408744 374 2861909
SGTC_1086 cerivastatin 2.18 µM 1.48370743489056 0.0621122359969538 no 273 0.0689432764992726 400 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1685 st024049 53.0905 µM 1.48209108050091 0.0623125781373408 no 274 0.0691580308904778 375 1941139
SGTC_741 4582-0002 126 µM 1.48174871477928 0.0623550779208445 no 275 0.0692035848573552 435 2912688
SGTC_913 3487-1245 167 µM 1.48153675815439 0.0623814006164241 no 276 0.0692317986377182 455 4016153
SGTC_2054 5233173 129 µM 1.47711429765553 0.0629326006989164 no 277 0.0698225007916023 498 6889
SGTC_1464 k208-0027 110 µM 1.47498079165351 0.0631998666343624 no 278 0.0701088538241576 457 X1464
SGTC_2021 4019055 173 µM 1.47494091020002 0.0632048710165839 no 279 0.0701142151864514 623 44827708 YER133W GLC7
SGTC_2809 7964133 12.99 µM 1.4686212022176 0.0640017826212265 no 280 0.0709677804024832 471 1253665
SGTC_2891 9063876 19.48 µM 1.46759982667016 0.0641313076985627 no 281 0.0711064775622241 335 6472478
SGTC_1645 Cervolide 78 µM 1.4624971421651 0.0647814556016796 no 282 0.0718025134580011 401 23173 A fragrance.
SGTC_2828 7998861 71.43 µM 1.4611851248872 0.0649494479173437 no 283 0.0719823220553466 348 2988188
SGTC_2298 7976326 193.81 µM 1.45721400800603 0.0654599757972124 no 284 0.0725286575170642 366 2235818
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.45149094039572 0.0662012028073664 no 285 0.0733216015677681 356 77254
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.44565077978768 0.0669642801810656 no 286 0.0741375880885544 435 6710655
SGTC_2770 toltrazuril 17.5 µM 1.44250785999494 0.0673777415968944 no 287 0.0745795779259882 471 68591 Kills coccidiodes.
SGTC_2617 dihydrotanshinone i 20.83 µM 1.4415383566377 0.0675056803716708 no 288 0.074716324600657 483 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_213 1246-0773 967 nM 1.43802885465711 0.0679703757275425 no 289 0.0752129336136999 477 6251622
SGTC_3090 9117696 49.47 µM 1.43510654056221 0.0683592025735233 no 290 0.0756283700203725 416 7923821
SGTC_116 0155-0182 31.788 µM 1.43180553933138 0.0688004772654125 no 291 0.0760997407712338 608 771486
SGTC_288 1315-0019 35.1 µM 1.42877590410754 0.0692074058800048 no 292 0.0765343266589893 477 6811474
SGTC_3215 9129942 49.47 µM 1.42817946690146 0.0692877349938711 no 293 0.0766201045419252 404 17682944
SGTC_339 3091-4833 71.4 µM 1.41964202189297 0.0704454590033233 no 294 0.077855962543598 442 3240077
SGTC_67 0335-0847 266 µM 1.4190285125673 0.0705292235501454 no 295 0.0779453518131062 629 4552207 YOR254C SEC63
SGTC_1550 gossypolone 36.6 µM 1.41622868209281 0.0709124663467971 no 296 0.0783542803956965 481 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_522 1273-0010 11.6 µM 1.41394500040846 0.0712262411939953 no 297 0.0786890258797353 458 5705015
SGTC_1418 3966-3099 2.4 µM 1.39860648685145 0.0733614224812505 no 298 0.0809655100174492 503 740335
SGTC_2939 9044578 71.43 µM 1.39797965750378 0.0734497096695743 no 299 0.081059588001455 473 2653634
SGTC_1400 3771-8998 51.5 µM 1.39107994366921 0.0744268922526656 no 300 0.0821005930047264 441 670767
SGTC_1001 4048-4355 44.4 µM 1.38901362028505 0.0747214614114707 no 301 0.0824143041894384 469 21824233
SGTC_4 0960-0234 25.671 µM 1.38812930397477 0.0748477985200832 no 302 0.0825488373828848 455 6821112
SGTC_3116 9124943 49.47 µM 1.3859653043698 0.0751576437768815 no 303 0.0828787490662506 459 41905195 YPL160W CDC60
SGTC_1786 berberine 21.6 µM 1.38589548105347 0.0751676574645933 no 304 0.0828894104470278 499 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2860 9025725 38.96 µM 1.38425734630329 0.0754028820247116 no 305 0.0831398347671809 436 40546248
SGTC_1333 1482-0047 286 µM 1.38287230568925 0.0756022014098273 no 306 0.0833520116900369 530 3811116
SGTC_1215 3852-0577 11.2 µM 1.38086886134544 0.075891224425716 no 307 0.0836596428750887 545 2884876
SGTC_1035 k081-0041 55.2 µM 1.37895392446221 0.0761682648321607 no 308 0.0839544802169448 525 731709
SGTC_340 k038-0059 454 µM 1.37677577612935 0.0764843199392529 no 309 0.0842907912003726 502 23733424
SGTC_859 0439-0102 54.6 µM 1.37521238509871 0.0767117864580604 no 310 0.0845328048629554 537 610143
SGTC_3246 9135460 32.98 µM 1.37008699390873 0.0774611166212857 no 311 0.0853298736482846 413 41446951
SGTC_576 1073-0113 22.7 µM 1.36768724155459 0.0778138643573712 no 312 0.0857049976082176 679 5439563
SGTC_2784 7567673 72.73 µM 1.36557363650338 0.0781255589490363 no 313 0.0860364130082357 540 3471247
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.36218735344607 0.0786269090252224 no 314 0.0865693829515564 579 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_11 0438-0307 1.3 µM 1.35960743769066 0.0790105075315324 no 315 0.0869770916181578 477 4011476
SGTC_2239 6685329 187.64 µM 1.3588046934575 0.0791301533906414 no 316 0.0871042428365694 515 805680
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.35756947594868 0.0793145255908747 no 317 0.087300167026045 533 688751
SGTC_2123 5259487 200 µM 1.35555307359104 0.0796161981930528 no 318 0.0876207055775026 537 2173474
SGTC_1249 0481-0015 10.2 µM 1.35435112911906 0.0797964328066067 no 319 0.0878121906463841 440 4227577
SGTC_1885 st057546 99.9 µM 1.35300314377117 0.0799989335586768 no 320 0.0880273130223747 541 702008
SGTC_1686 st019653 115.5 µM 1.34765552525818 0.0808061075935391 no 321 0.0888846014312536 487 97252
SGTC_2583 asiatic acid 100 µM 1.34595627470323 0.081063877069201 no 322 0.0891583092223367 489 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.34535889275621 0.0811546447872073 no 323 0.0892546817326865 548 6708561
SGTC_2190 6049624 200 µM 1.34434052889437 0.0813095543262735 no 324 0.0894191477045377 439 2265554
SGTC_1817 st052116 64.4 µM 1.34232598839494 0.0816166553091694 no 325 0.0897451602583803 491 4361398
SGTC_1914 st062367 72.6 µM 1.33869124674066 0.0821729544705084 no 326 0.0903356035191894 498 978205
SGTC_255 tunicamycin 200.472 nM 1.3312494081027 0.0833208346699296 no 327 0.0915534794866462 547 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2176 5809774 33.9695 µM 1.32625322414487 0.0840982162374674 no 328 0.092377917472228 544 2870539
SGTC_3245 9134821 49.47 µM 1.32347085659484 0.0845334927847674 no 329 0.0928394208986094 546 17014901
SGTC_3081 9117243 49.47 µM 1.31880519753238 0.085267183224555 no 330 0.0936171231036567 515 45595589
SGTC_2636 apigenin dimethyl ether 100 µM 1.31768916501538 0.0854433880724586 no 331 0.0938038615526332 570 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2927 9011802 47.9 µM 1.31558813565144 0.0857758489665101 no 332 0.0941561589193808 522 43912568
SGTC_2125 5246583 200 µM 1.3106037655429 0.0865684335574942 no 333 0.0949958331918716 615 835267
SGTC_3202 9113761 49.47 µM 1.30987476303338 0.0866848125769811 no 334 0.0951191029602085 615 4798415
SGTC_2385 9074692 200 µM 1.30876386819938 0.0868623822377731 no 335 0.0953071748147267 550 17046906
SGTC_863 0466-0191 129 µM 1.30865254253696 0.0868801919264302 no 336 0.0953260370668975 591 765160 YPR165W RHO1
SGTC_779 1360-0071 233 µM 1.30834114427029 0.0869300233755786 no 337 0.0953788128360713 586 7566
SGTC_2485 5633444 17.78 µM 1.30578479941301 0.0873399093523152 no 338 0.0958128753567525 540 5724239
SGTC_619 1652-1634 108 µM 1.30347814916581 0.0877109958514395 no 339 0.0962057857670398 514 5400454
SGTC_1153 4055-0057 267 µM 1.2998192400861 0.0883020402055747 no 340 0.0968314647972308 553 882706
SGTC_1134 3477-0009 42.5 µM 1.29841893308332 0.0885290234007325 no 341 0.0970717083235 601 3973534
SGTC_1807 st050092 58.9 µM 1.29799422083626 0.0885979530998114 no 342 0.0971446604327067 527 5008496
SGTC_164 4100-3994 89.624 µM 1.2964017615282 0.0888567611061835 no 343 0.0974185527590624 620 4615967
SGTC_2879 9041815 71.43 µM 1.29614699505408 0.0888982181736125 no 344 0.0974624233933984 423 4942971
SGTC_2179 6298986 200 µM 1.29539419917345 0.089020801592145 no 345 0.0975921390604866 506 738374
SGTC_3287 9117173 37.0625 µM 1.29328739846585 0.0893645365364764 no 346 0.0979558387009428 477 2789709
SGTC_807 1315-0151 48 µM 1.29200681007603 0.0895739527653293 no 347 0.0981773931049004 627 4011080
SGTC_2407 paclitaxel 400 µM 1.29079161880214 0.089773011764895 no 348 0.0983879724066987 576 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1404 3909-7820 48.3 µM 1.28801958016542 0.0902283263673006 no 349 0.0988695736990122 540 23741373
SGTC_2495 cafestol 54.53 µM 1.28260899514956 0.0911219666136139 no 350 0.0998145485884399 518 16667697 An anti-infammatory.
SGTC_1830 st055982 50.3 µM 1.27937220178143 0.0916597007923728 no 351 0.100383009018936 573 455313 An antimicrobial agent.
SGTC_3107 9121808 49.47 µM 1.27873327253413 0.0917661245341452 no 352 0.100495499347491 455 662681
SGTC_2648 atorvastatin 78.68 µM 1.27542451490439 0.0923187150431397 no 353 0.10107951311887 540 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.26855363690676 0.0934740695118481 no 354 0.102300154542288 580 688669
SGTC_403 arphamenine a 50 µM 1.26664395343772 0.0937970759794814 no 355 0.102641314342737 578 5487158 An arginine aminopeptidase inhibitor.
SGTC_1615 st002656 86.5 µM 1.26473906681041 0.0941200911951532 no 356 0.102982440315609 564 1584458
SGTC_1155 4088-0394 48.2 µM 1.26346288848122 0.0943369537740152 no 357 0.103211437813462 569 2326248
SGTC_2602 kawain 100 µM 1.26264619976655 0.0944759279437347 no 358 0.103358178369813 632 5369129
SGTC_3157 9099274 49.47 µM 1.25888091423763 0.0951186111173669 no 359 0.104036674256411 538 17217662
SGTC_2145 5634607 200 µM 1.25768565595983 0.0953232972609071 no 360 0.104252730910728 501 308662
SGTC_2300 7976697 71.57 µM 1.25640061512909 0.0955437200614686 no 361 0.104485379370085 494 2236109
SGTC_2610 ononetin 44.17 µM 1.25403826869017 0.0959499111023749 no 362 0.104914048059501 599 259632
SGTC_1371 2421-0008 32.7 µM 1.25141200807441 0.0964029696779327 no 363 0.105392099235044 581 2827552
SGTC_1136 pergolide 1.05886 µM 1.25098924685511 0.0964760472476936 no 364 0.105469200330768 664 47811 A dopamine receptor agonist.
SGTC_2713 st079149 53.4 µM 1.25085053946466 0.0965000327661694 no 365 0.105494505983206 616 3103253
SGTC_57 miconazole 162.5 nM 1.24922088522431 0.0967821635429727 no 366 0.105792147570901 555 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1888 azatryptophan 97.5 µM 1.24633808095569 0.097282726194568 no 367 0.106320151457264 530 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2193 5925765 200 µM 1.24188955966885 0.0980588790020806 no 368 0.10713865632538 525 877370
SGTC_462 ag-879 158 µM 1.24052821421989 0.0982973031409678 no 369 0.107390042562178 626 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1860 st056228 74.6 µM 1.23874284332854 0.0986106336907893 no 370 0.107720373459383 572 688679
SGTC_623 k072-0108 16.9 µM 1.23837653695095 0.0986750103309676 no 371 0.10778823819196 588 5382803
SGTC_2302 7771753 200 µM 1.23766444344534 0.0988002454622982 no 372 0.107920254220279 620 2203047
SGTC_561 1550-0330 72.9 µM 1.23097153200283 0.0999830086406999 no 373 0.109166755897121 561 6812934
SGTC_3168 9103419 49.47 µM 1.22985279835975 0.10018171431011 no 374 0.109376116281514 485 16649256
SGTC_1677 st019204 53.9 µM 1.2278056414199 0.100546069507587 no 375 0.109759968711175 572 3945625
SGTC_2215 7188065 200 µM 1.22737009295074 0.100623713458115 no 376 0.10984176088549 531 940217
SGTC_3165 9101544 49.47 µM 1.22511414845869 0.101026574080425 no 377 0.110266107544008 603 5002184
SGTC_1161 k007-0610 110 µM 1.22220417303738 0.101547964500041 no 378 0.110815213095981 700 5843850
SGTC_1579 chlormadinone acetate 49.4 µM 1.21916711697387 0.10209421139999 no 379 0.111390384941672 622 45114258 A steroidal progestin.
SGTC_700 3453-2283 142 µM 1.20617845666262 0.104454486299746 no 380 0.113874344352514 673 565664
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.20550704919232 0.104577559050974 no 381 0.114003809189327 599 689007
SGTC_1162 k048-0130 20.1 µM 1.20510657003891 0.10465101912063 no 382 0.114081081905336 625 6797406
SGTC_3266 9136860 49.47 µM 1.19924552898408 0.105730391406249 no 383 0.115216244299511 617 4871271 YPR165W RHO1
SGTC_201 4262-0159 12.803 µM 1.19825393549296 0.105913796909277 no 384 0.115409086889563 543 1341029
SGTC_2843 9000894 45.46 µM 1.19760851659357 0.106033297296828 no 385 0.115534729496737 469 2242070
SGTC_840 0245-0196 390 µM 1.19181224858014 0.107110854058476 no 386 0.116667435972557 675 3827528
SGTC_3319 9138450 16.7555 µM 1.19180743358867 0.107111752461618 no 387 0.116668380179792 604 2029690
SGTC_3209 9113616 49.47 µM 1.19129252183593 0.107207858419489 no 388 0.116769384301887 672 16649353
SGTC_2628 lathosterol 100 µM 1.18707177754003 0.107997985732401 no 389 0.117599654714913 634 6710616
SGTC_404 fumagillin 50 µM 1.18644139197759 0.108116353470789 no 390 0.117724016820185 652 12015870 A methionine aminopeptidase binder.
SGTC_362 0310-0100 9.03 µM 1.18464448705359 0.108454271467777 no 391 0.118079019901015 614 790235
SGTC_842 0271-0008 11.1 µM 1.18433665403261 0.108512237341455 no 392 0.118139912400674 675 1221709
SGTC_1101 ebselen 5.29 µM 1.18145469089362 0.109056000896078 no 393 0.118711071329654 680 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2411 st077133 39.94 µM 1.18133781547941 0.109078093982518 no 394 0.118734275254648 707 1403142 YNL221C POP1
SGTC_1902 st060212 70.5 µM 1.18114710585075 0.109114150936925 no 395 0.118772144775692 650 688944
SGTC_2310 7668677 200 µM 1.18030487434582 0.109273491815689 no 396 0.118939490096962 623 2197143
SGTC_822 1487-0950 154 µM 1.17805287828667 0.109700365454501 no 397 0.119387763077073 631 1958375
SGTC_575 k072-0246 11.9 µM 1.17724755899029 0.109853306727365 no 398 0.119548355608906 649 6796779
SGTC_2616 abietic acid 100 µM 1.17602631277558 0.110085530176062 no 399 0.119792180755255 683 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1238 0333-0287 48.8 µM 1.17084788601073 0.111074135336663 no 400 0.120829962888335 642 7226
SGTC_699 0375-0592 111 µM 1.17046493801463 0.11114749499448 no 401 0.120906958039741 673 762578
SGTC_2067 5224629 34.075 µM 1.16832087035285 0.111558865502792 no 402 0.12133867998482 637 2835000
SGTC_1113 artemisinin 1.17947 µM 1.16829293146454 0.11156423316508 no 403 0.121344312806618 684 2240 An anti-malaria and mitochondrial poison.
SGTC_1705 st027868 56.3335 µM 1.1638100071232 0.112427894574845 no 404 0.122250507902673 624 292948
SGTC_2977 9011197 71.43 µM 1.1634555822326 0.112496379782014 no 405 0.122322354789125 581 2704722
SGTC_2105 5350118 200 µM 1.16312299085066 0.112560673218628 no 406 0.122389802668456 658 2133313
SGTC_1041 0206-0046 107 µM 1.16003080547014 0.113159681972752 no 407 0.123018132051066 647 50494
SGTC_1129 3453-1384 223 µM 1.159403119051 0.113281552675373 no 408 0.123145953002197 692 1084452
SGTC_2819 7996655 46.38 µM 1.15819403678339 0.113516570187752 no 409 0.123392430649704 561 6456960
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.15607345233037 0.113929601768059 no 410 0.123825556916172 645 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.15557814236363 0.114026228611479 no 411 0.123926876386292 641 75037 A free radical scavenger.
SGTC_1948 st076329 66.6 µM 1.15150564701356 0.114822919527408 no 412 0.124762136711171 607 24208413
SGTC_3139 9095020 49.47 µM 1.15141447337618 0.114840800777873 no 413 0.124780881150198 513 25236292
SGTC_2909 7941780 10.49 µM 1.14849062414899 0.115415285660504 no 414 0.125383040677114 677 1243215
SGTC_1219 1469-0211 33.1 µM 1.1482486395037 0.11546292272647 no 415 0.125432967547218 640 6822282
SGTC_2253 7938677 135.83 µM 1.14749413194272 0.115611544679331 no 416 0.125588728490118 653 2301972
SGTC_3144 9087057 49.47 µM 1.14602555447285 0.115901212810003 no 417 0.12589228929311 650 17249618
SGTC_965 1291-5240 308 µM 1.14408199547548 0.116285359963865 no 418 0.12629481684566 695 2834598
SGTC_1936 st074407 74.3 µM 1.14331663918578 0.116436881358562 no 419 0.126453574503291 701 809813
SGTC_198 3454-2873 16.191 µM 1.14328937833898 0.116442280905962 no 420 0.126459231776843 666 710957
SGTC_1938 st074717 56.4 µM 1.14294474139727 0.116510558354196 no 421 0.1265307673378 599 17250979
SGTC_2376 9072922 81.32 µM 1.1415068680923 0.116795727735918 no 422 0.126829527771723 686 17087968
SGTC_1811 st050069 61.5 µM 1.13983208039539 0.117128507062538 no 423 0.127178132872572 636 3877702
SGTC_1483 3453-0561 55.9 µM 1.13510484202883 0.118071428840234 no 424 0.128165696518616 711 4546991
SGTC_286 k060-0067 22.9 µM 1.13457663055033 0.118177121425651 no 425 0.128276374670035 648 5985051
SGTC_2692 st077426 47.7 µM 1.13198133839767 0.11869739886778 no 426 0.12882114009573 692 25238571
SGTC_2305 7443522 69.23 µM 1.13024116018959 0.119047156922279 no 427 0.129187310195283 723 5415886
SGTC_2257 7960413 200 µM 1.12759769706665 0.119579857229175 no 428 0.129744929864738 736 2974689 YIL048W NEO1
SGTC_856 0433-0016 11.3 µM 1.12757284459585 0.11958487336681 no 429 0.129750180212797 705 3911780
SGTC_2767 sibutramine 71.45 µM 1.12575735184952 0.119951707726784 no 430 0.130134120323013 706 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_187 1488-2104 32.728 µM 1.12567791828351 0.119967775986107 no 431 0.130150936854079 705 2852859
SGTC_2167 5876490 200 µM 1.12473077049887 0.120159487167158 no 432 0.130351569219385 690 686534
SGTC_3009 9080819 71.4286 µM 1.12364605986558 0.120379307359796 no 433 0.130581603930699 678 17027216
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.12330186460391 0.120449118830634 no 434 0.130654656091218 611 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3305 9127027 53.8275 µM 1.12234183523357 0.120643987634716 no 435 0.13085856245789 684 41905295
SGTC_1498 4478-3555 97.6 µM 1.12142141355087 0.120831025098529 no 436 0.131054262717729 636 3437919
SGTC_648 0375-0473 33.3 µM 1.11926694518065 0.121269628947541 no 437 0.131513136529409 724 1713139
SGTC_2682 pyrogallin 40.03 µM 1.11891252603987 0.121341888237141 no 438 0.131588729309425 733 822798 An ATP competetive kinase inhibitor.
SGTC_2082 5219693 150 µM 1.11697053970008 0.121738359554886 no 439 0.132003460876791 693 2834649
SGTC_3336 9143619 71.43 µM 1.11302795510481 0.122546065913251 no 440 0.132848211733153 751 45595730
SGTC_2794 7785382 27.27 µM 1.11173413139398 0.122811945560155 no 441 0.133126240036918 785 2205081
SGTC_2608 thymoquinone 42.66 µM 1.11167150007078 0.12282482650031 no 442 0.133139708965081 645 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_564 3555-0129 330 µM 1.11059282139627 0.123046819376404 no 443 0.133371827057319 606 563260
SGTC_1228 0124-0032 52.5 µM 1.11021167138931 0.123125327540944 no 444 0.133453912271951 699 X1228
SGTC_2063 5246145 200 µM 1.10808454546381 0.123564111414482 no 445 0.133912652346727 721 711240
SGTC_2112 5488546 200 µM 1.10543836557011 0.12411149284158 no 446 0.134484843661651 707 600757
SGTC_1897 st060201 15 µM 1.10492972656463 0.124216902589752 no 447 0.134595020216509 657 611878
SGTC_2515 chrysin 20.77 µM 1.10375695795261 0.124460184391094 no 448 0.134849290278425 707 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_727 3032-0951 202 µM 1.10238886589262 0.124744405298673 no 449 0.135146324973504 673 3652836
SGTC_2976 9009005 19.48 µM 1.09989270755268 0.125264149920143 no 450 0.135689436218933 717 2993148
SGTC_3089 9117425 49.47 µM 1.09903785466283 0.125442492583065 no 451 0.135875777328484 638 9401657
SGTC_2505 galangin 7.89 µM 1.09750784452172 0.125762131406386 no 452 0.13620972673479 618 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.09405489615215 0.126485583476908 no 453 0.13696545124529 681 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1556 plumbagin 1.48 µM 1.09031892548685 0.127271593394885 no 454 0.137786340658163 643 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2294 7971431 200 µM 1.08936920702483 0.127471944939098 no 455 0.137995552432727 637 5741572
SGTC_1196 1588-0294 184 µM 1.08911873054996 0.12752482170609 no 456 0.138050765533555 665 6144269
SGTC_2553 4-methylesculetin 85.09 µM 1.08499781585208 0.128396956276485 no 457 0.138961311317627 714 5319502
SGTC_2061 5245884 80.95 µM 1.0819293235583 0.129049043876117 no 458 0.139641966945298 722 573863
SGTC_2693 st077581 40.7 µM 1.08033896538817 0.129387914083818 no 459 0.139995632073359 814 25238761
SGTC_557 1315-0110 16.2 µM 1.08032618506842 0.129390639782991 no 460 0.139998476634212 726 6833801
SGTC_2532 xanthone 78.9 µM 1.0796398940777 0.129537065671344 no 461 0.140151284523931 652 7020 An insecticide.
SGTC_662 k832-1615 104 µM 1.07924669859983 0.129621008902196 no 462 0.140238883511482 711 5878478
SGTC_292 k038-0015 474 µM 1.07650817107763 0.130206701742277 no 463 0.140850024259439 691 46368540
SGTC_196 k015-0023 18.111 µM 1.0752816047134 0.130469622126221 no 464 0.141124334722728 751 5211998
SGTC_1010 4112-3296 15.2 µM 1.07521987665045 0.130482863529831 no 465 0.141138149212787 759 704384
SGTC_2248 tofa 1.1 µM 1.07370670291421 0.130807747953414 no 466 0.141477078108141 697 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3227 9130768 49.47 µM 1.07215968611555 0.131140476174485 no 467 0.141824157091329 761 17720899
SGTC_1038 k292-0204 154 µM 1.07175145257264 0.131228375353943 no 468 0.141915841882952 681 4454212
SGTC_1997 st073024 93.8 µM 1.06981725035189 0.131645392933096 no 469 0.142350788001237 728 686268
SGTC_948 3448-0295 75.3 µM 1.06832759006265 0.131967189221208 no 470 0.14268638362663 775 678569
SGTC_284 0988-0104 32.6 µM 1.06580079273713 0.132514267511866 no 471 0.14325685124635 770 4666532
SGTC_312 4092-0653 6.84 µM 1.06569642521311 0.1325368977381 no 472 0.143280447075666 831 1148278
SGTC_279 1273-0055 2.93 µM 1.06555521466088 0.132567520952761 no 473 0.143312376702756 799 2847562
SGTC_2479 5617353 43.85 µM 1.06209293532367 0.133319883326517 no 474 0.144096748485365 751 2731746
SGTC_686 1319-0111 510 µM 1.06073594603146 0.133615560437141 no 475 0.144404959585451 776 4562600
SGTC_3356 9151811 4.48 µM 1.05897695649961 0.133999500799644 no 476 0.144805137177048 731 1859254 YPR165W RHO1
SGTC_1972 st070201 17.4 µM 1.0580881875088 0.134193783304058 no 477 0.145007619627157 757 2829099
SGTC_1884 5633444 25 µM 1.05799841777662 0.134213417478347 no 478 0.145028081872796 756 5724239
SGTC_445 e6 berbamine 66 µM 1.05708661758987 0.134412955562562 no 479 0.145236029083987 853 6610268 A calcium/calmodulin antagonist.
SGTC_1034 k072-0165 12.7 µM 1.05486728219738 0.134899485198809 no 480 0.145743013815791 788 5835461
SGTC_1590 st077108 57.8 µM 1.05335665592438 0.135231339596111 no 481 0.14608878078538 745 5489485
SGTC_2473 5854593 8.94 µM 1.05331440457487 0.135240629411887 no 482 0.146098459604397 722 2872951
SGTC_1093 fluphenazine 7.97 µM 1.05265282619563 0.135386147890459 no 483 0.146250068278 770 6602611 An atypical antipsychotic.
SGTC_1966 st070145 16.1 µM 1.05200027342045 0.13552978622079 no 484 0.146399712092812 733 3748532
SGTC_2861 9024595 19.48 µM 1.05177801892474 0.13557873216994 no 485 0.146450703094591 657 16482810
SGTC_2188 6126565 140.678 µM 1.05177044527027 0.135580400289739 no 486 0.146452440899304 703 874518
SGTC_535 2293-4129 48.2 µM 1.05167297799594 0.135601869000108 no 487 0.146474806382939 823 396118 YIL048W NEO1
SGTC_1564 D-Arginine 115 µM 1.0507497531784 0.135805339394909 no 488 0.146686769350994 714 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3269 9137823 49.47 µM 1.04904801395965 0.136180934982683 no 489 0.147078010345048 675 17682936
SGTC_3303 9125618 40.5795 µM 1.04676808384476 0.136685258007178 no 490 0.147603276932156 823 22695467
SGTC_956 1185-0240 191 µM 1.0464436338352 0.136757130360376 no 491 0.147678128048552 726 1416193
SGTC_970 1315-0089 19.5 µM 1.04524328310222 0.137023257327599 no 492 0.147955271784287 718 6811083 YLR033W RSC58
SGTC_1005 4092-0690 4.4 µM 1.04482973969626 0.137115024976398 no 493 0.148050833597169 699 1529343
SGTC_2946 9065502 71.43 µM 1.04307505375985 0.137504866805881 no 494 0.148456766686443 596 16489101
SGTC_2584 androsterone 48.74 µM 1.04098746361142 0.137969655350825 no 495 0.148940683273471 916 2754130 A steroid.
SGTC_1297 1068-0111 14.1 µM 1.03978860547259 0.138237057283419 no 496 0.149219062044567 741 767057
SGTC_355 1311-2252 105 µM 1.03774195398828 0.138694373132445 no 497 0.149695103595243 751 5338538
SGTC_156 3474-0145 5.642 µM 1.03745596635139 0.13875835786051 no 498 0.14976170357331 771 2265471
SGTC_2518 prenyletin 46.28 µM 1.03734510011707 0.138783167646703 no 499 0.149787527098667 670 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1438 4092-1045 4 µM 1.03127250485968 0.140146716720899 no 500 0.151206524111477 787 1351342
SGTC_1355 1499-0035 1.68 µM 1.02807068709925 0.140869309642024 no 501 0.151958289034247 743 1548538
SGTC_2973 9094665 17.96 µM 1.02288788144754 0.142044324728389 no 502 0.153180429968075 840 25237061 YIL048W NEO1
SGTC_3242 9133940 49.47 µM 1.02077570534808 0.142525082277014 no 503 0.153680358618844 813 17248444
SGTC_295 k015-0027 31 µM 1.0200651689007 0.142687056286175 no 504 0.15384877725772 768 3887424
SGTC_2898 9056270 58.44 µM 1.01933330701807 0.142854021711021 no 505 0.154022378335559 710 19154699
SGTC_147 4466-0538 29.23 µM 1.01894340536673 0.142943026944654 no 506 0.15411491773593 802 6742687 YHR072W ERG7
SGTC_446 go6976 132 µM 1.01878090848672 0.142980132162193 no 507 0.154153495660907 751 3501 A protein kinase C inhibitor.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.01859441840533 0.143022724107982 no 508 0.154197777615291 596 4000243
SGTC_1773 st048542 73.5835 µM 1.0176164374891 0.143246222770319 no 509 0.154430136314241 755 3237138
SGTC_363 0455-0021 3.06 µM 1.01664933604768 0.143467466983866 no 510 0.154660137670722 776 4597466
SGTC_1197 1601-0112 267 µM 1.0162305394707 0.14356334680015 no 511 0.154759808365433 800 7350313
SGTC_2896 9052656 71.43 µM 1.01622143301231 0.143565432124558 no 512 0.154761976110991 851 6469436
SGTC_3349 9149703 23.001 µM 1.01540185299789 0.143753194763514 no 513 0.154957155065309 761 4910494
SGTC_725 1497-0963 19 µM 1.01418520550706 0.144032229466747 no 514 0.155247193344636 817 3549977
SGTC_1226 3909-7979 35.4 µM 1.0135512587968 0.144177768027395 no 515 0.155398462686505 836 6615510
SGTC_2189 6047310 154.431 µM 1.01210533349541 0.14451008774299 no 516 0.155743846269064 754 711535
SGTC_3181 9108277 49.47 µM 1.01207680361936 0.144516650005647 no 517 0.155750666198477 768 17097298
SGTC_1944 st076371 56.9 µM 1.01057297747756 0.144862834865928 no 518 0.156110427353299 761 24208455
SGTC_2462 5162487 171.77 µM 1.00932079757019 0.145151515781228 no 519 0.156410404516057 814 2259986
SGTC_358 0075-0058 9.45 µM 1.0083533861203 0.145374810325843 no 520 0.156642421186536 870 1069125
SGTC_3047 9092122 49.47 µM 1.00809444915292 0.145434616435984 no 521 0.156704561092812 755 17173831
SGTC_632 0781-2353 4.65 µM 1.00553499812715 0.146026657452443 no 522 0.157319652937785 806 6811515 YHR007C ERG11
SGTC_511 blebbistatin 171 µM 1.00144246653307 0.14697668419953 no 523 0.158306470994684 788 3476986 A myosin inhibitor.
SGTC_2524 avocatin b 10.57 µM 0.999757380838848 0.147369056464751 no 524 0.158713967787352 748 6710748
SGTC_2129 girgensonine 121.053 µM 0.997226178671878 0.147959765007333 no 525 0.159327368358347 846 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2175 5807670 165.306 µM 0.99670753721576 0.148080996129541 no 526 0.159453245053417 803 241186
SGTC_2107 5363541 170.161 µM 0.996596858476222 0.148106875607751 no 527 0.159480115725415 843 244052
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.996257850511785 0.148186163044551 no 528 0.159562438791058 814 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1650 st011916 45.8 µM 0.995549414127135 0.148351944347831 no 529 0.159734561855258 816 242528
SGTC_1887 st057648 70.8 µM 0.993341768008051 0.14886935131167 no 530 0.160271714640407 811 688672
SGTC_45 0kpi-0036 14.9 µM 0.992802399606896 0.148995946388658 no 531 0.160403130160488 758 2795021
SGTC_1317 1273-0028 910 nM 0.992221100146129 0.149132463598727 no 532 0.160544840870599 823 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_763 3453-1109 128 µM 0.984801761684134 0.150882219660642 no 533 0.162360727568136 855 1560353
SGTC_607 4491-0986 66.8 µM 0.981794637855257 0.15159528764749 no 534 0.163100515185783 854 698981 YDR232W HEM1
SGTC_173 1273-0061 2.693 µM 0.981134508303312 0.15175212105771 no 535 0.163263207572315 795 2847414 YPL266W DIM1
SGTC_2004 4023728 41.89 µM 0.980351217179999 0.151938354988804 no 536 0.163456390512449 828 360084 YDR527W RBA50
SGTC_1405 3909-7894 12 µM 0.979993395420637 0.152023480565119 no 537 0.163544689405836 828 7104060
SGTC_571 k831-0106 44.2 µM 0.979913265737253 0.152042547707746 no 538 0.163564467076681 779 4783639
SGTC_1934 st074720 32.6 µM 0.978201977652413 0.152450133953078 no 539 0.163987219271851 851 17250992
SGTC_968 1309-0633 340 µM 0.977611257445664 0.152590997007583 no 540 0.164133313713282 825 3761976
SGTC_263 alizarin 107.927 µM 0.975367882181272 0.153126738417599 no 541 0.16468890467452 888 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1208 2323-2347 50.3 µM 0.97136474005083 0.154085824018908 no 542 0.165683340242896 853 5412760
SGTC_1171 0368-0077 21.4 µM 0.970690190319177 0.154247825194473 no 543 0.165851289131852 786 3239779
SGTC_1804 st050076 49.1 µM 0.969910893339605 0.154435122860002 no 544 0.166045454867069 837 3895976
SGTC_84 0443-0269 128.823 µM 0.969873644419552 0.154444079097245 no 545 0.166054739298082 852 6150058
SGTC_527 4476-4215 268 µM 0.967396720520195 0.155040408370206 no 546 0.16667287443318 821 4418754
SGTC_465 cgp-37157 41 µM 0.967343724832389 0.155053183883584 no 547 0.166686116113318 723 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1111 tnp00062 510.699 nM 0.967054206982293 0.155122989364812 no 548 0.166758467997853 876 676306
SGTC_743 1275-0778 158 µM 0.96525065892348 0.155558308942177 no 549 0.167209639412195 874 2849257 YMR203W TOM40
SGTC_1968 st069590 43.6 µM 0.964318337603116 0.155783657541472 no 550 0.167443174986936 809 6384066
SGTC_3182 9108849 49.47 µM 0.963798056653792 0.155909506624979 no 551 0.167573590592266 864 17133045
SGTC_1961 st076550 68.7 µM 0.96352861609533 0.155974707067749 no 552 0.167641155299026 782 1579337
SGTC_2514 salinomycin 42.74 µM 0.960841940911487 0.156625823787455 no 553 0.16831582342611 920 23682228 A polyether potassium ionophore.
SGTC_3333 9141820 12.094 µM 0.959491168090899 0.156953859051442 no 554 0.168655683410441 802 1939433
SGTC_635 k038-0028 24.7 µM 0.955583431277606 0.157905396511639 no 555 0.169641367827004 865 4035102
SGTC_51 1013-0126 23.419 µM 0.953585077598849 0.158393458269242 no 556 0.170146856111718 816 1627850
SGTC_3086 9117350 49.47 µM 0.950314815983002 0.159194293149887 no 557 0.170976156417301 816 2679265
SGTC_1426 4048-4480 71.7 µM 0.949936274363704 0.159287162911666 no 558 0.171072316873579 870 14224343
SGTC_862 0452-0056 10.2 µM 0.94929864780474 0.159443675648196 no 559 0.171234370544951 846 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1016 4226-1401 38 µM 0.948521725915361 0.159634516043966 no 560 0.171431958931246 848 2901613
SGTC_1636 st007707 68.9 µM 0.945344693480697 0.160416466062758 no 561 0.172241463984031 876 403051
SGTC_3218 9131285 49.47 µM 0.944037802930167 0.160738850983891 no 562 0.172575165407363 931 17156417
SGTC_3207 9114163 49.47 µM 0.942934060886776 0.161011452356467 no 563 0.172857315776454 907 849233
SGTC_826 1683-5028 118 µM 0.94251403750085 0.161115268624523 no 564 0.172964763833446 851 722377
SGTC_1969 st069479 40.1 µM 0.94207093268455 0.161224837213149 no 565 0.173078162570013 825 3895485
SGTC_3219 9131112 49.47 µM 0.940450786728853 0.161625871938442 no 566 0.173493190978301 826 17612988 YMR079W SEC14
SGTC_835 0312-0010 67.2 µM 0.939978191753637 0.161742975770114 no 567 0.173614373585128 827 1626196
SGTC_3048 9093155 49.47 µM 0.939445507710566 0.16187503528138 no 568 0.173751028754891 811 25236002
SGTC_2866 9034245 58.44 µM 0.938592384413878 0.16208668228528 no 569 0.173970032154822 864 6462273
SGTC_1751 st044839 27.194 µM 0.9380977861326 0.162209467137899 no 570 0.174097079726461 863 5291326
SGTC_1419 3993-2473 62.6 µM 0.936904000321305 0.162506075888616 no 571 0.174403970650308 881 704026
SGTC_321 4534-3890 65.3 µM 0.934436798456639 0.163120196054621 no 572 0.175039311627175 888 699746
SGTC_3230 9131665 49.47 µM 0.933054102768806 0.163465026523039 no 573 0.175396017459512 793 15943720
SGTC_2853 9015042 58.44 µM 0.932970142342211 0.163485980649341 no 574 0.175417692279817 815 6457456
SGTC_1151 3909-8316 15.3 µM 0.932711959307782 0.163550426695754 no 575 0.17548435420963 871 800431
SGTC_2717 st081029 62.2815 µM 0.931993253912167 0.163729912341305 no 576 0.175670005903461 855 5292846
SGTC_3030 9087619 49.47 µM 0.931892428558386 0.163755102149556 no 577 0.175696060457881 900 25236973
SGTC_3197 9113331 49.47 µM 0.928156207432907 0.164690318450157 no 578 0.176663273474806 874 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_645 0845-0943 5.41 µM 0.928147895127331 0.164692402960025 no 579 0.176665429066746 838 1885106
SGTC_1567 st069303 68.4 µM 0.927511437112126 0.164852060824866 no 580 0.176830528178957 875 5581319
SGTC_3195 9113082 49.47 µM 0.927050324731112 0.164967795186547 no 581 0.176950203011903 859 17018038
SGTC_2143 5623677 140.463 µM 0.925935453926922 0.165247833368299 no 582 0.177239762490565 862 5375313
SGTC_612 0302-0167 22.4 µM 0.925629571526835 0.16532472001506 no 583 0.177319259988643 956 235821
SGTC_50 0929-0078 56.389 µM 0.92514097988943 0.165447580493642 no 584 0.1774462895155 818 1377751
SGTC_773 4358-1457 44.6 µM 0.923451769850805 0.165872801547427 no 585 0.17788591175917 941 1186886
SGTC_1903 st060211 78.3 µM 0.92225317737018 0.166174948595488 no 586 0.178198265499425 935 688960
SGTC_1033 k072-0102 21.3 µM 0.917356965337177 0.167412899469075 no 587 0.179477807855946 901 5965931
SGTC_589 1227-0070 34.1 µM 0.917224635958026 0.167446439696455 no 588 0.1795124698693 880 2841384
SGTC_1924 st058459 75.1 µM 0.914044562044327 0.168253763806364 no 589 0.180346715398088 885 688683
SGTC_1982 st072467 71.9 µM 0.911719233660592 0.16884567615827 no 590 0.180958268198974 930 3163533
SGTC_829 1635-0120 117 µM 0.908750354225385 0.169603346513558 no 591 0.18174095888413 930 285054
SGTC_2985 9022375 71.43 µM 0.904343900368155 0.170731906210293 no 592 0.182906537614132 901 4939335
SGTC_3342 9147791 14.508 µM 0.903320785217435 0.170994627521557 no 593 0.183177834116723 917 1838168
SGTC_705 1124-0212 310 µM 0.903318144615782 0.170995305924652 no 594 0.183178534642042 917 9554485
SGTC_1407 3909-7909 12.3 µM 0.902817444124837 0.171123973164236 no 595 0.183311395691888 947 4411780
SGTC_1799 st045822 46.1415 µM 0.900917224471432 0.171612844305404 no 596 0.183816166186524 901 3674992
SGTC_1784 st039334 36.3 µM 0.899992945431308 0.171850956613189 no 597 0.184062002469392 902 3496984
SGTC_2032 5185112 25.99 µM 0.899470066781328 0.171985753743001 no 598 0.184201166384454 865 5718189
SGTC_1234 0326-0494 15.5 µM 0.894891444902747 0.173168996028956 no 599 0.185422560220364 923 1547813
SGTC_3180 9109287 49.47 µM 0.893666420474668 0.173486453219517 no 600 0.18575019847371 855 18891271
SGTC_2621 lithochol-11-enic acid 100 µM 0.892125233630127 0.173886367634439 no 601 0.18616290553418 952 6708711
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.888400495191329 0.174855298571386 no 602 0.187162679554322 959 165521
SGTC_2266 7929956 200 µM 0.888005435230354 0.174958267697931 no 603 0.187268913825942 915 2967153
SGTC_2928 9011484 9.79 µM 0.887788693994003 0.175014775858549 no 604 0.187327212832351 862 2994751
SGTC_3211 9128781 49.47 µM 0.88753042131197 0.175082127098541 no 605 0.187396697606735 850 17194361
SGTC_2428 5615643 7.78 µM 0.886345430783826 0.175391354579076 no 606 0.187715707486192 901 2253075
SGTC_1338 1486-1223 76 µM 0.885951591224721 0.175494205023283 no 607 0.187821806790601 953 3444526
SGTC_782 0083-0095 30.5 µM 0.884157244958455 0.175963278806108 no 608 0.188305667373691 972 3591729 An indicator and reagent.
SGTC_2601 securinine 100 µM 0.883103186529696 0.176239198099921 no 609 0.18859026132735 869 442872 A GABA receptor antagonist.
SGTC_1836 st055642 81 µM 0.883102922536225 0.176239267239375 no 610 0.188590332638332 961 8571
SGTC_2474 5321570 43.32 µM 0.880557781305813 0.17690663324594 no 611 0.189278608997916 937 2841384
SGTC_3111 9122088 49.47 µM 0.878978499555364 0.177321541413907 no 612 0.189706466793553 833 16876704
SGTC_1803 st050068 52.4 µM 0.878606814489643 0.177419279593847 no 613 0.189807249834474 1054 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_572 0960-0087 17.7 µM 0.878442198649913 0.177462577784628 no 614 0.189851896218871 1020 6796365
SGTC_1440 4100-1550 40 µM 0.87781368276208 0.177627954939455 no 615 0.190022418919535 973 742806
SGTC_3128 9127691 49.47 µM 0.875241668427636 0.178305724588289 no 616 0.190721212700409 831 41316314
SGTC_2996 9066192 71.4286 µM 0.874894220113878 0.17839740792732 no 617 0.190815732131052 916 6472854
SGTC_1175 0741-0056 27.6 µM 0.874614148948996 0.178471333656792 no 618 0.19089194327938 1009 765927
SGTC_1272 0839-0021 27 µM 0.872913254814494 0.178920704767979 no 619 0.191355180504511 941 5027250
SGTC_2906 7926292 26.41 µM 0.872839949622259 0.178940087771528 no 620 0.191375160591504 952 2966319
SGTC_1218 1348-1416 30.7 µM 0.872069860973372 0.179143790730507 no 621 0.191585133458303 957 6787668
SGTC_1448 4255-0083 152 µM 0.871562498096754 0.179278077450874 no 622 0.19172354843069 996 5399660
SGTC_1491 4138-0063 26.5 µM 0.869146902475746 0.179918295198481 no 623 0.192383392748653 936 23883227
SGTC_2871 9038510 12.99 µM 0.866874212377417 0.180521947168036 no 624 0.193005467163757 999 4945164
SGTC_1445 4239-0156 97.7 µM 0.865795743950572 0.180808844394881 no 625 0.193301091790856 1029 4008346
SGTC_1427 4048-4900 550 nM 0.865082119620361 0.180998841807008 no 626 0.1934968589256 978 24132586
SGTC_3056 9094900 49.47 µM 0.864592201519135 0.181129351420457 no 627 0.193631327166484 947 25236784
SGTC_2980 9014342 25.29 µM 0.864362899736397 0.181190455524205 no 628 0.193694283395853 868 2996599
SGTC_351 caspofungin 25 nM 0.864302661381208 0.181206509920471 no 629 0.193710824280407 1062 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2981 9013952 38.96 µM 0.863700634232442 0.181367007840337 no 630 0.193876182571552 910 2996344
SGTC_639 0833-0042 114 µM 0.86349825876557 0.1814209802762 no 631 0.193931788186438 975 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_610 4215-0184 155 µM 0.862460234253019 0.181697973797346 no 632 0.194217153323807 971 5605015
SGTC_307 1501-1223 22.3 µM 0.861057063165026 0.182072825867252 no 633 0.194603307796771 938 2830329
SGTC_1691 st019933 84.6 µM 0.860231075156717 0.182293711473407 no 634 0.194830839050541 959 6176082
SGTC_1189 1431-2119 7.28 µM 0.859264423525684 0.182552425886765 no 635 0.195097323671234 991 3107275
SGTC_254 nsc-64875 3.808 µM 0.858495133588065 0.182758482246183 no 636 0.195309558247288 993 56993
SGTC_3334 9142812 21.919 µM 0.858093531404343 0.182866110123662 no 637 0.195420409461577 921 45283678
SGTC_653 0203-0016 55.2 µM 0.857958326476628 0.182902353435936 no 638 0.195457737652491 978 295302
SGTC_1455 4262-0120 131 µM 0.85513161676492 0.183661113434614 no 639 0.196239144075235 999 1529587
SGTC_617 3770-0098 35 µM 0.852722843510126 0.184309234148891 no 640 0.196906509939803 926 5962639
SGTC_716 1683-5115 658 µM 0.852710010686946 0.184312690841187 no 641 0.196910069030229 1044 723597
SGTC_291 SEC14.278 35.5 µM 0.851571397958112 0.184619551942023 no 642 0.197226010020925 996 1068044
SGTC_2820 7989630 71.43 µM 0.850043470380152 0.185031833951386 no 643 0.19765045923727 865 2984098
SGTC_932 2857-0803 154 µM 0.849409107893159 0.185203172433695 no 644 0.197826843445314 1023 674898
SGTC_3341 9147222 25.867 µM 0.848401716510822 0.18547546676576 no 645 0.198107143522759 916 1939759
SGTC_2184 6075246 200 µM 0.84663999742018 0.18595225008914 no 646 0.198597906362457 948 2267320
SGTC_728 3030-5151 22.5 µM 0.841620188640781 0.18731494998179 no 647 0.200000292541335 945 3125388
SGTC_1296 1068-0102 11.9 µM 0.841174827716913 0.187436147116499 no 648 0.200125000116668 974 767053
SGTC_152 4469-0003 551.229 µM 0.841047874754024 0.187470704005671 no 649 0.200160557362662 992 697280
SGTC_2316 5844804 197.44 µM 0.837870653813886 0.18833683286777 no 650 0.201051676018267 1111 776813
SGTC_1850 st056238 17 µM 0.836809682710682 0.188626608661126 no 651 0.201349776935287 1077 5393177
SGTC_1991 st073000 8.92 µM 0.835616971368223 0.188952693750341 no 652 0.201685209024157 1021 4301969 YIL048W NEO1
SGTC_2730 imipramine 71.33 µM 0.833984965147749 0.189399443565023 no 653 0.202144728098464 1070 3696 A tricyclic antidepressant.
SGTC_568 1193-0097 7.48 µM 0.831406862788701 0.190106503650872 no 654 0.202871911725003 969 3646150
SGTC_1266 0828-0227 32.9 µM 0.830033125812305 0.190483920845516 no 655 0.203260027472452 959 3913820
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.82957896095341 0.190608798133603 no 656 0.203388438039628 1045 688788
SGTC_2290 7904846 200 µM 0.828027763170428 0.191035694695633 no 657 0.203827388519072 984 2962154
SGTC_2131 toluylene red 5.2905 µM 0.827228947058338 0.191255761005738 no 658 0.204053653746311 967 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1302 1159-0335 255 µM 0.82602425200679 0.191587936892975 no 659 0.204395167319755 978 649284
SGTC_513 4245-1575 41.7 µM 0.825295161930079 0.191789143672021 no 660 0.204602018949196 1052 719745
SGTC_841 0251-0215 91.2 µM 0.824945449524926 0.191885699599257 no 661 0.204701280751048 1045 3888614
SGTC_2339 9000433 200 µM 0.822785265105422 0.192482787940095 no 662 0.205315058700735 932 2988954
SGTC_447 ml7 120 µM 0.822097626683899 0.192673093536097 no 663 0.205510668067564 1032 4216 Selective myosin light chain kinase inhibitor.
SGTC_2262 9014885 67.46 µM 0.821789122318893 0.192758510216334 no 664 0.205598462843777 967 6457424
SGTC_959 1222-0044 107 µM 0.821763260038599 0.192765671847058 no 665 0.205605823793483 1020 6083612
SGTC_609 0986-0026 86.3 µM 0.82114627940644 0.192936570695634 no 666 0.205781475856793 999 2848610
SGTC_960 1222-0186 7.7 µM 0.82104032028717 0.192965929857475 no 667 0.205811650975942 1000 3126296
SGTC_2959 9079155 11 µM 0.8194563395114 0.193405144572933 no 668 0.206263051130613 975 16189457
SGTC_3027 9089541 49.47 µM 0.817216470677264 0.194027267542886 no 669 0.206902365784154 1020 9943819
SGTC_12 0849-0099 9.267 µM 0.815692789013551 0.194451165714938 no 670 0.207337932154752 987 6071388
SGTC_122 0236-0016 402.397 µM 0.815645107644477 0.194464440072906 no 671 0.207351571304105 1121 6808838
SGTC_3160 9100216 49.47 µM 0.815249495607193 0.194574598615304 no 672 0.20746475570341 1017 17191039
SGTC_1923 st058458 19.1 µM 0.814535214950115 0.19477358688656 no 673 0.20766920349531 1071 3534982
SGTC_366 0181-0206 4.31 µM 0.811973318975365 0.195488311697938 no 674 0.208403470699898 1032 274874
SGTC_1380 2291-0730 164 µM 0.811442678878039 0.195636550019468 no 675 0.208555749116521 979 2999191
SGTC_1994 st072947 40.9 µM 0.811287202894192 0.195679996334551 no 676 0.208600378667061 996 5286565 YDL195W SEC31
SGTC_2421 5690543 90.72 µM 0.810972828306505 0.195767863277561 no 677 0.208690637434948 1005 3397993
SGTC_2533 agelasine 13.65 µM 0.810447712773304 0.195914685206032 no 678 0.208841452476117 1051 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2144 5628481 200 µM 0.808613257789511 0.196428121669441 no 679 0.209368818220524 1019 2818399
SGTC_2566 crystal violet carbinol 226 nM 0.806482169920993 0.197025604101233 no 680 0.209982442372635 953 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_417 st075190 100 µM 0.803661776888331 0.197818032623489 no 681 0.210796167344491 1051 222757
SGTC_1648 st011736 69.8 µM 0.802065289938502 0.198267440018515 no 682 0.211257595949665 1026 2855514
SGTC_303 1348-1668 34.2 µM 0.801370788819206 0.198463132675346 no 683 0.211458510425898 1020 5380509
SGTC_1209 2323-2347 50.3 µM 0.80075121804676 0.198637810189401 no 684 0.211637842460816 1059 5412760
SGTC_289 k017-0060 526 µM 0.800424426108048 0.198729980994513 no 685 0.211732466800179 1057 5512909
SGTC_1450 4112-4260 37.6 µM 0.799621383821461 0.198956586473753 no 686 0.211965097102052 1050 1633175
SGTC_2121 5257820 149.641 µM 0.798175030630247 0.199365116430383 no 687 0.21238446261658 1101 791256
SGTC_3061 glucosamine 200 µM 0.797494718216843 0.199557448728 no 688 0.212581884571346 1023 91431 and experimental redox chemotherapeutic
SGTC_349 k015-0014 24 µM 0.796656825530405 0.199794484219343 no 689 0.21282518246594 983 2196908
SGTC_1289 0976-0073 69.1 µM 0.79605256606841 0.199965531145282 no 690 0.213000741390495 1052 3391136
SGTC_1475 4092-1048 11.7 µM 0.795933147350498 0.199999345260741 no 691 0.213035446784014 1059 2881759
SGTC_1913 st060213 96.1 µM 0.795614467430249 0.200089598189609 no 692 0.213128077491708 1081 688959
SGTC_2077 5212015 200 µM 0.793295597172727 0.200747059347358 no 693 0.213802810704931 1007 780900
SGTC_2453 5731132 22.18 µM 0.788633958463758 0.202072674700747 no 694 0.21516298864374 1089 1362040
SGTC_1179 1021-1431 9.29 µM 0.788611095173688 0.202079189144023 no 695 0.215169672073497 1068 2840958
SGTC_313 3474-0040 5.03 µM 0.787839389899086 0.202299145034534 no 696 0.215395328735487 1055 1043375 YIL048W NEO1
SGTC_27 0485-0001 32.618 µM 0.787326836734363 0.202445315003724 no 697 0.215545281797338 989 2054479
SGTC_3025 9087895 49.47 µM 0.78713622276437 0.202499690422323 no 698 0.215601063449937 1098 17173641
SGTC_114 0364-0001 490.298 µM 0.784955087323104 0.203122512526381 no 699 0.216239950941893 1064 4003655
SGTC_1231 0242-0792 125 µM 0.783895352277369 0.203425531676855 no 700 0.21655075857728 1056 3707635
SGTC_3292 9120825 59.784 µM 0.781510575252869 0.204108417015122 no 701 0.217251129663979 1084 24824900
SGTC_1081 sertraline 6 µM 0.781017912967735 0.204249661773008 no 702 0.217395979627532 1078 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2307 7538926 6.34 µM 0.778870011435871 0.204866138210858 no 703 0.218028145434297 1064 96582
SGTC_1640 st009078 66.4 µM 0.777574623743227 0.205238466045383 no 704 0.218409912923892 1018 690618
SGTC_1874 staurosporine 7.6 µM 0.776860636563501 0.205443856125036 no 705 0.218620498654749 1085 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2115 tiliquinol 12.7705 µM 0.775540865088566 0.205823831136213 no 706 0.219010063958101 1045 71208 A bioactive hydroxyquinoline.
SGTC_1190 1486-1332 13 µM 0.774204925630956 0.206208885414625 no 707 0.219404807965397 1071 4150046
SGTC_2502 avocadyne acetate 18.59 µM 0.77353052494247 0.206403428219206 no 708 0.219604235365062 1120 3952079
SGTC_2140 5586273 200 µM 0.772990711254065 0.206559225357575 no 709 0.21976393895412 1097 854421
SGTC_1248 0469-0687 58.6 µM 0.771828211735103 0.206894974025193 no 710 0.220108090114182 1062 4017482
SGTC_2568 diosmetin 100 µM 0.76993633123093 0.207442069760376 no 711 0.220668830628497 1093 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1149 3909-7961 23.3 µM 0.769486185488533 0.207572369150417 no 712 0.220802371175561 1063 735261
SGTC_2743 auranofin 4.32 µM 0.769165438417256 0.207665242244133 no 713 0.220897552450932 1044 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3010 9080089 71.4286 µM 0.768180153458177 0.207950687393625 no 714 0.221190081336106 1075 17027233
SGTC_1090 efavirenz 20.7 µM 0.767181052567982 0.208240371547775 no 715 0.221486938312048 1081 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1720 st037298 9.481 µM 0.765456102221033 0.208741072034819 no 716 0.221999998354053 1053 597396
SGTC_484 loperamide 105 µM 0.764547781014015 0.209005014905943 no 717 0.222270437075752 1037 3955 An opioid-receptor agonist.
SGTC_2008 4012253 172 µM 0.762368016489775 0.209639219120708 no 718 0.222920194783557 1091 603940
SGTC_2103 5378138 10 µM 0.761944769578745 0.209762494226462 no 719 0.223046484171439 1154 244142
SGTC_1612 st002233 45.4 µM 0.759533937800561 0.210465486623034 no 720 0.223766610235576 1139 1035021
SGTC_172 1112-0046 2.638 µM 0.758630860756856 0.210729177202866 no 721 0.224036703217562 989 2802135 YIL048W NEO1
SGTC_1855 st056195 39.6 µM 0.754579376549329 0.21191455773768 no 722 0.22525070092788 1070 4028379
SGTC_3075 9116269 49.47 µM 0.752558105293633 0.212507395380755 no 723 0.225857750464425 1110 17015205 YNL244C SUI1
SGTC_1861 st057647 17.4 µM 0.750746240565173 0.213039636735237 no 724 0.226402694304383 1119 688668
SGTC_872 0588-0139 234 µM 0.749689439595657 0.213350434338968 no 725 0.226720884630415 1152 2047100
SGTC_2740 felodipine 17.08 µM 0.748376549574342 0.213736913839891 no 726 0.227116531603366 1070 3333 L-type calcium channel blocker
SGTC_444 curcumin 90.4 µM 0.746317797082171 0.21434377553736 no 727 0.227737731535551 1064 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2807 7945238 51.95 µM 0.746277929871207 0.214355537140162 no 728 0.227749770343435 1102 17148797
SGTC_993 3909-8757 62.7 µM 0.745511760779782 0.214581644839477 no 729 0.227981202041021 1036 4288324 YLR208W SEC13
SGTC_1008 4106-0037 6 µM 0.74394913485507 0.215043228074897 no 730 0.228453624049414 1104 2905394
SGTC_2458 5808907 16.39 µM 0.743509870696281 0.215173085816009 no 731 0.228586523872842 1203 2731747
SGTC_1941 st076221 61.8 µM 0.743059619046742 0.215306238969243 no 732 0.228722793027007 1142 2828568
SGTC_3313 9133968 57.047 µM 0.742348544673214 0.215516622714728 no 733 0.228938093329466 1126 1494643
SGTC_2101 5377231 179.231 µM 0.739426631996568 0.216382372114431 no 734 0.229823987771978 1123 2844213
SGTC_2917 7979103 53.79 µM 0.739235607389865 0.216439041847297 no 735 0.229881971270654 1131 2980565
SGTC_2791 5663188 71.43 µM 0.736845633217989 0.217148781866716 no 736 0.230608114454238 1098 54690634
SGTC_663 1486-0733 13.9 µM 0.735423868835673 0.217571633991078 no 737 0.231040694828018 1112 722445 YPR165W RHO1
SGTC_2096 5468907 200 µM 0.733872944031184 0.218033441668703 no 738 0.231513089100604 1151 759785
SGTC_153 4077-0274 519.67 µM 0.733139301337622 0.21825208987978 no 739 0.231736735886135 1158 3121976
SGTC_306 1672-3436 11.6 µM 0.7322744941289 0.218509991337255 no 740 0.232000521935463 1158 6797378
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.731402578495423 0.218770190223603 no 741 0.232266645385525 1163 4213774
SGTC_784 4579-0127 173 µM 0.729051114308109 0.219472807255334 no 742 0.232985198198426 1183 1948547
SGTC_41 0478-0632 82.643 µM 0.728045978193563 0.219773536777519 no 743 0.233292720682527 1176 3750424
SGTC_1769 st044406 64.4 µM 0.727766279604265 0.219857262643338 no 744 0.233378334813894 1140 670903
SGTC_882 0843-0131 351 µM 0.727399307959235 0.219967140864847 no 745 0.233490689160596 1180 5425421
SGTC_1649 st011737 51.3 µM 0.726254366035641 0.220310160480659 no 746 0.233841424530946 1108 1761035
SGTC_1247 0448-0043 5.84 µM 0.725785659406758 0.220450671365606 no 747 0.233985089786748 1164 3089013 YGL099W LSG1
SGTC_2278 7948257 134.34 µM 0.725242913382123 0.220613442250944 no 748 0.234151510243052 1126 1247028
SGTC_95 0471-0001 561.058 µM 0.722822408602224 0.221340195350531 no 749 0.234894499130065 1108 4015405
SGTC_2212 7123476 200 µM 0.722664281290404 0.221387720444608 no 750 0.234943082581844 1106 1085715
SGTC_1843 st055809 45.5 µM 0.722466633281795 0.221447131670524 no 751 0.235003816283476 1123 16413835
SGTC_2249 haloperidol 116.36 µM 0.719053970380733 0.222474384094683 no 752 0.236053833355622 1190 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_697 0508-1955 564 µM 0.717568790681749 0.222922288263988 no 753 0.236511603347094 1161 6243113
SGTC_2850 9015429 58.44 µM 0.717410571641032 0.22297003461209 no 754 0.236560399240198 1159 6457570
SGTC_1055 3448-0672 86 µM 0.717123658493565 0.223056632316037 no 755 0.236648899452937 1133 748378
SGTC_1092 toremifene 6.32 µM 0.717032342594641 0.223084197800206 no 756 0.23667707025205 1182 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2156 5649887 115 µM 0.716474408559829 0.223252663191988 no 757 0.236849232011711 1220 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2993 9054257 71.4286 µM 0.715950466278114 0.223410930851299 no 758 0.237010967605109 1194 6470217 YGL055W OLE1
SGTC_689 0833-0039 98 µM 0.715347708812267 0.223593085213841 no 759 0.237197107693654 1167 5374726
SGTC_2222 6885208 172.143 µM 0.714958802530374 0.223710658188764 no 760 0.237317250101134 1117 609514
SGTC_2603 homopterocarpin 100 µM 0.71443383813803 0.223869419573552 no 761 0.237479477083812 1177 101795 A weak amylase inhibitor.
SGTC_2204 7233102 200 µM 0.712933241759153 0.224323587597163 no 762 0.23794353400383 1102 2172480
SGTC_2623 humulene 100 µM 0.711332726039689 0.224808572977219 no 763 0.238439038239381 1100 6187145 An anti-inflammatory.
SGTC_2482 5981709 142.65 µM 0.708878291107329 0.225553465059548 no 764 0.239200003927775 1148 877755
SGTC_500 h-89 112 µM 0.707957129948097 0.225833386703969 no 765 0.239485940104244 1210 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_432 NS 1619 61.3 µM 0.707677639017684 0.225918356995337 no 766 0.239572733330754 1157 4552 A K+/calcium channel activator.
SGTC_3318 9139014 38.6185 µM 0.707234456219222 0.226053129622424 no 767 0.239710394690652 1143 16643984
SGTC_969 1313-0238 134 µM 0.706971901256014 0.226132994455628 no 768 0.239791969822311 1198 5212874
SGTC_2580 diallyl disulphide 81.36 µM 0.705534921796174 0.226570381950945 no 769 0.240238703704391 1170 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2097 5376186 200 µM 0.705143741798683 0.226689531879669 no 770 0.240360393784153 1138 742755
SGTC_1951 sophoraflavanone G 9.2 µM 0.704660718153177 0.226836705339279 no 771 0.240510701328829 1209 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_767 0929-0023 86 µM 0.704405705498789 0.226914427400916 no 772 0.24059007693636 1261 1204563
SGTC_695 3505-6186 243 µM 0.704328654738563 0.226937913675957 no 773 0.24061406267266 1198 1819379
SGTC_2348 9022543 33.42 µM 0.704299210899909 0.226946888979855 no 774 0.240623228820208 1174 3162678 YDL140C RPO21
SGTC_2481 5478948 45.16 µM 0.703803452030077 0.22709804018126 no 775 0.24077759182181 1182 77792
SGTC_3105 9121040 49.47 µM 0.703164569566112 0.227292911796419 no 776 0.240976598241008 1040 41448907
SGTC_1608 st001473 40.5 µM 0.701907423426244 0.22767664087975 no 777 0.24136844956132 1150 7292267
SGTC_534 k292-0788 63.4 µM 0.701173651859531 0.227900784474091 no 778 0.241597325397309 1241 4146317
SGTC_886 0866-0150 153 µM 0.700057665618558 0.228241920226815 no 779 0.241945646270284 1211 271463
SGTC_195 4234-0266 16.654 µM 0.699523398156104 0.228405337171728 no 780 0.242112497845499 1186 2303354
SGTC_2213 7173844 200 µM 0.699405796942035 0.228441316804032 no 781 0.242149233046989 1179 892728
SGTC_1212 0520-0165 585 µM 0.699216403524849 0.228499267673884 no 782 0.242208400397764 1277 5403258
SGTC_1724 st037281 8.293 µM 0.697938456991104 0.228890511388489 no 783 0.242607841376757 1201 574124 YDL195W SEC31
SGTC_1700 st030840 7.9285 µM 0.697059473162533 0.229159830630701 no 784 0.242882787605612 1198 5499307
SGTC_2517 totarol 10 µM 0.696761609154548 0.229251135988621 no 785 0.242975997730041 1158 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_365 0121-0052 13.6 µM 0.696484562010023 0.229336078582771 no 786 0.243062711031555 1203 3101739
SGTC_918 glabranin 770.725 nM 0.695809148902743 0.229543234013317 no 787 0.243274179467701 1210 124049 Also referred to as licorice root.
SGTC_83 0170-0301 39.027 µM 0.695636062543406 0.229596338067914 no 788 0.243328387936707 1154 3089716
SGTC_2757 clomiphene 4.22 µM 0.694632420389944 0.229904397825877 no 789 0.243642844657566 1249 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1009 4106-0057 9.87 µM 0.694623666565088 0.229907085758343 no 790 0.243645588332226 1224 2928005
SGTC_186 3455-3465 67.277 µM 0.692148050362813 0.230667949254386 no 791 0.244422179445784 1150 755278
SGTC_1950 st077106 7.18 µM 0.691923519120184 0.230737026891012 no 792 0.24449267992907 1176 13831864
SGTC_2886 9058944 51.95 µM 0.690682003990582 0.231119190858547 no 793 0.244882700494896 1072 4949929
SGTC_1122 capsaicin 818.572 nM 0.69043675211338 0.231194726204493 no 794 0.244959785678491 1227 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_443 clozapine 122 µM 0.690006340824432 0.231327322255435 no 795 0.245095099922738 1134 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2034 5197015 53.07 µM 0.687304436994769 0.232160661181981 no 796 0.245945451692067 1197 780676
SGTC_553 k007-0256 45.7 µM 0.685163788125515 0.232822078680731 no 797 0.24662028587727 1240 6287000
SGTC_3093 9117344 49.47 µM 0.684276045420504 0.233096680164493 no 798 0.246900435190211 1194 24824913
SGTC_1137 ixabepilone 100 µM 0.682755814621302 0.233567343732539 no 799 0.247380577167453 1227 154225 A novel microtubule stabilizer.
SGTC_38 0929-0051 58.268 µM 0.682485399021298 0.233651119597922 no 800 0.247466036109751 1214 1379719
SGTC_2499 avocadenofuran 51.48 µM 0.680362326569858 0.234309434712772 no 801 0.248137534563873 1182 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_986 1493-0483 84 µM 0.679808219277412 0.234481419206204 no 802 0.248312950829018 1168 40079
SGTC_393 acivicin 6.25 µM 0.677938362531547 0.23506230278 no 803 0.248905387519698 1146 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_112 phenothiazine 287.218 µM 0.67506914024586 0.235955189674042 no 804 0.24981591939705 1221 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2756 carbadox 75.1 µM 0.67432210499268 0.236187969433624 no 805 0.25005327672999 1234 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1687 st020778 55.3625 µM 0.673794067486687 0.236352584718586 no 806 0.250221123524166 1234 4259299
SGTC_3259 9138485 49.47 µM 0.672201986469923 0.236849296870428 no 807 0.250727558275066 1343 17646153
SGTC_2880 9042983 58.44 µM 0.668938519783288 0.237869255054628 no 808 0.251767348536968 1248 6464714
SGTC_1977 st070720 65.3 µM 0.666981595437687 0.238482022063436 no 809 0.252391944741027 1229 682188
SGTC_3152 9099253 49.47 µM 0.666754731388687 0.238553115315084 no 810 0.252464406272952 1251 25236131
SGTC_1255 0566-0045 221 µM 0.664606093682018 0.239227016996351 no 811 0.253151235339168 1276 2788469
SGTC_849 0386-0493 241 µM 0.664465566271919 0.239271128418064 no 812 0.253196190253828 1217 726119
SGTC_245 methotrexate 289.6 µM 0.66418268971883 0.239359936575835 no 813 0.253286695587604 1254 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3034 9090421 49.47 µM 0.663523742322178 0.239566880730751 no 814 0.25349758937275 1195 17173761
SGTC_2921 7974240 10.71 µM 0.663152834697219 0.239683408189346 no 815 0.25361633761769 1258 2979074 YDR527W RBA50
SGTC_3 0833-0587 95.581 µM 0.66291296790822 0.239758783224179 no 816 0.2536931479276 1186 5382644
SGTC_3249 9135183 49.47 µM 0.662770309241697 0.239803617996973 no 817 0.253738835977656 1272 4902779
SGTC_1064 honokiol 6.76 µM 0.662007371895436 0.240043471608144 no 818 0.253983248601426 1248 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_978 1416-0512 87.4 µM 0.661724952184706 0.240132292382928 no 819 0.254073755163491 1270 6814003
SGTC_402 epigallocatechin gallate 10 µM 0.661494020918136 0.240204933394022 no 820 0.254147773883043 1227 65064 An antioxidant.
SGTC_1014 4130-3005 69.3 µM 0.661317412451701 0.240260494876675 no 821 0.254204388541406 1261 743608
SGTC_124 0136-0217 7.121 µM 0.658950809938264 0.24100570942794 no 822 0.254963678308783 1365 3976905
SGTC_657 3534-0529 86.7 µM 0.654964138110177 0.242263901357105 no 823 0.256245421838375 1303 1049549
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.654348280135234 0.242458582833403 no 824 0.256443723706957 1263 688761
SGTC_1587 estradiol valerate 56.1 µM 0.654255325782869 0.242487974387125 no 825 0.256473661287926 1252 13791 A steroid.
SGTC_1388 3346-4487 254 µM 0.651808958285139 0.243262192981616 no 826 0.2572622109472 1316 3345614
SGTC_1573 oleylamine 1.06 µM 0.651473627648071 0.243368421384395 no 827 0.257370397848407 1273 5356789 An amine of the fatty acid oleic acid.
SGTC_2523 spermine 47.74 µM 0.651007595460332 0.243516095962702 no 828 0.25752079192083 1242 1103 A DNA binding polyamine.
SGTC_53 0973-0023 39.979 µM 0.65067854824292 0.24362039238924 no 829 0.257627006817671 1251 674768
SGTC_2605 digitonin 300 nM 0.64927698698966 0.244064908215485 no 830 0.258079678882886 1314 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2003 4023581 200 µM 0.649266753502097 0.244068155451943 no 831 0.258082985580273 1291 16641307
SGTC_2940 9060638 45.86 µM 0.648396779893239 0.244344296077907 no 832 0.258364176254262 1271 4027022
SGTC_1721 st082152 9.2685 µM 0.646656272939619 0.244897260043138 no 833 0.258927214633354 1232 5296051
SGTC_982 1491-0518 27.5 µM 0.645769909892593 0.245179118663806 no 834 0.259214188855744 1245 3091256
SGTC_1342 1486-1464 234 µM 0.643841788275884 0.245792852805873 no 835 0.2598390163717 1293 3253938
SGTC_805 3852-0218 479 µM 0.642102694857613 0.246347124625225 no 836 0.260403253144656 1235 6615355
SGTC_2543 pimpinellin 60.67 µM 0.641231074961289 0.246625173117595 no 837 0.260686281385249 1226 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1995 st072814 61.1 µM 0.640835139148461 0.2467515329324 no 838 0.260814900038523 1229 5769371
SGTC_249 wiskostatin 11.211 µM 0.640347538326633 0.246907194535321 no 839 0.260973340662719 1287 2775510 A n-wasp and actin depolymerizer.
SGTC_1912 st060209 90.8 µM 0.639963347403064 0.247029880588332 no 840 0.261098214208746 1252 688787
SGTC_1494 4358-1428 177 µM 0.638274952089422 0.247569432656445 no 841 0.261647357049413 1338 1564571
SGTC_736 0958-0254 92.6 µM 0.637003961490393 0.247976011744472 no 842 0.26206113160057 1337 6812352
SGTC_35 0133-0054 64.071 µM 0.635939038867244 0.248316945581564 no 843 0.262408078199523 1236 99677
SGTC_833 3852-0053 558 µM 0.635855633266678 0.248343658343579 no 844 0.262435261265792 1354 3123681
SGTC_596 1155-0152 116 µM 0.635634482926468 0.2484144947722 no 845 0.262507344271989 1288 280313
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.635463971163765 0.248469118563775 no 846 0.262562928769457 1387 6728940
SGTC_2968 9090663 33.37 µM 0.634667017282425 0.248724509215659 no 847 0.262822804659699 1272 25236811
SGTC_1250 0485-0349 40.2 µM 0.632028760968595 0.24957095726925 no 848 0.263684041902263 1291 6842794 YDL195W SEC31
SGTC_2859 9028643 45.46 µM 0.631074528604841 0.249877485958888 no 849 0.263995897394197 1257 17151580
SGTC_217 ketoconazole 989 nM 0.630281999240603 0.250132222521902 no 850 0.264255049059977 1239 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_684 1140-0066 328 µM 0.62878697034795 0.250613132821138 no 851 0.264744265685631 1286 6813534
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.628467217025778 0.250716052346632 no 852 0.264848957955412 1260 4620898
SGTC_1403 3909-7815 62.9 µM 0.628055151757362 0.250848717470753 no 853 0.264983905637049 1273 6615483
SGTC_1115 galangin 695.678 nM 0.626421143122083 0.251375155010602 no 854 0.265519372556369 1337 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_935 2996-0153 430 µM 0.626247701526274 0.251431067905996 no 855 0.265576241818176 1307 23738523
SGTC_3251 9135047 49.47 µM 0.626047435386673 0.251495636486686 no 856 0.265641914186069 1342 17682963
SGTC_1025 k007-0731 70 µM 0.622772842623835 0.25255265232806 no 857 0.266716903474723 1279 6256118
SGTC_2019 4016004 108 µM 0.62273103208088 0.252566163598147 no 858 0.266730643319788 1269 45595336
SGTC_2058 5236698 133 µM 0.621170038483237 0.253070878279311 no 859 0.26724387532224 1307 766665
SGTC_2122 5258151 111.688 µM 0.619792870816964 0.253516596839617 no 860 0.267697081451618 1281 2173356
SGTC_3295 9122362 53.5725 µM 0.618292049125295 0.254002805128948 no 861 0.268191421015255 1301 4730473
SGTC_583 1488-1091 88.9 µM 0.617717658804816 0.254189014790094 no 862 0.268380734752569 1387 4303273
SGTC_1423 4048-0112 5.59 µM 0.615322017952853 0.254966420769395 no 863 0.269171039807305 1323 X1423
SGTC_2667 digitoxin 100 µM 0.614393125683521 0.255268188632896 no 864 0.269477788645339 1292 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_199 4063-0024 41.6 µM 0.613604478000329 0.255524541930454 no 865 0.269738361858825 1344 306215
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.613094241987707 0.255690467950817 no 866 0.269907013641185 1341 5379071
SGTC_3297 9117502 71.43 µM 0.611813682780331 0.256107146604383 no 867 0.27033051792883 1303 7453720
SGTC_1454 4239-0054 42.6 µM 0.611494631305328 0.256211017220683 no 868 0.27043608574077 1411 1340767
SGTC_2870 9038528 12.99 µM 0.610228172931837 0.256623542807775 no 869 0.270855334818188 1314 6463316
SGTC_469 w7 172 µM 0.609959520037338 0.2567110960095 no 870 0.270944311506426 1353 45115570 A P450 inhibitor.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.609031789915007 0.257013560111943 no 871 0.271251683844889 1240 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1856 st057054 55.7 µM 0.6079902410669 0.257353352828617 no 872 0.2715969731985 1438 1266018
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.607910723113555 0.257379304187939 no 873 0.271623343604504 1371 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2935 9038016 29.96 µM 0.606225268288237 0.257929686389121 no 874 0.272182587871297 1296 6463195
SGTC_3293 9120939 62.045 µM 0.605622699961685 0.258126602043932 no 875 0.272382662528709 1355 934087
SGTC_72 0744-0168 198.391 µM 0.60251291418768 0.25914409891093 no 876 0.273416384748721 1337 677577
SGTC_2741 miltefosine 3.04 µM 0.602383543139139 0.259186472955998 no 877 0.273459430957141 1286 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2443 5493264 126.67 µM 0.601837841998917 0.259365250690628 no 878 0.273641041456344 1372 5340055
SGTC_3322 9139058 2.11 µM 0.601582233840539 0.259449012657455 no 879 0.273726128912264 1381 4908926 YPR165W RHO1
SGTC_2337 9009472 200 µM 0.601364682760141 0.25952031444795 no 880 0.273798558144667 1414 5742383
SGTC_287 k060-0039 29.6 µM 0.601134097227582 0.259595899290788 no 881 0.27387533727928 1396 5861974
SGTC_3346 9158254 43.5805 µM 0.600802222377877 0.259704706238584 no 882 0.273985861870198 1319 17639500
SGTC_2703 st077852 53.4 µM 0.60011610820671 0.259929727056539 no 883 0.274214428986728 1336 6281836
SGTC_1240 0356-0016 42.1 µM 0.600048686746319 0.259951844300471 no 884 0.274236894365332 1362 4305613
SGTC_2747 doxorubicin 7.63 µM 0.599732104321389 0.260055710423321 no 885 0.27434239435498 1253 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2625 euphol 100 µM 0.598385168512453 0.260497859680632 no 886 0.274791479864438 1366 6708538 A triterpene alcohol.
SGTC_2525 harmine 47.85 µM 0.598176925176572 0.260566252806987 no 887 0.274860943170311 1354 5280953 A monoamine oxidase inhibitor
SGTC_2074 5212007 75.395 µM 0.596520145288256 0.261110716338111 no 888 0.275413899997392 1285 758611
SGTC_1117 retinoic acid 1.10837 µM 0.596127525609455 0.261239827640346 no 889 0.275545018538657 1406 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1583 clindamycin 39.6 µM 0.595628047452763 0.261404126291938 no 890 0.27571186769664 1277 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2093 5331342 194.4 µM 0.595089909523181 0.261581201080423 no 891 0.275891686591435 1354 33839
SGTC_3125 9127534 49.47 µM 0.594195204832816 0.261875740712518 no 892 0.276190779802877 1258 1639235
SGTC_766 1391-0721 126 µM 0.593636266609091 0.262059831234227 no 893 0.276377709475283 1413 1020919 YIL115C NUP159
SGTC_2286 7945697 125 µM 0.592957347266517 0.262283527625935 no 894 0.276604848718517 1302 1245733
SGTC_2183 6420625 130.508 µM 0.592951152122212 0.262285569307491 no 895 0.276606921787074 1335 2897619
SGTC_2065 5221596 34.26 µM 0.592546922520534 0.262418805447247 no 896 0.276742204774723 1362 788581
SGTC_86 0417-1630 471.922 µM 0.592442326040711 0.262453286623566 no 897 0.276777215218967 1364 3634867
SGTC_14 0354-0009 295 µM 0.591672126556485 0.262707261261564 no 898 0.277035082521891 1385 1713507
SGTC_353 1988-1175 58.3 µM 0.590736725161681 0.263015880508573 no 899 0.277348418442217 1274 2788357
SGTC_2052 5265182 7.135 µM 0.590466127118821 0.263105194120553 no 900 0.277439094280102 1403 1239884
SGTC_514 4466-0038 2.65 nM 0.5903632766813 0.263139145008397 no 901 0.277473562666803 1307 5722064
SGTC_2393 9031399 185.94 µM 0.590138436034373 0.263213372609461 no 902 0.277548921062696 1408 1526623 YDL150W RPC53
SGTC_1309 pyrazolanthrone 13.4 µM 0.588769529991841 0.26366552607147 no 903 0.278007944195723 1411 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1474 0330-0125 5.35 µM 0.587715942245694 0.264013798659891 no 904 0.278361486516736 1364 X1474
SGTC_1306 1185-0270 9.02 µM 0.586936205550944 0.264271698265648 no 905 0.278623276288422 1361 1548076
SGTC_407 eburnamonine 100 µM 0.586759596001906 0.264330130070952 no 906 0.278682588048119 1304 3195
SGTC_98 0074-0023 107.663 µM 0.585483000729516 0.264752691006946 no 907 0.279111496802928 1310 3563821
SGTC_2389 9091542 195.52 µM 0.584430242943798 0.265101418583296 no 908 0.279465442241992 1345 3626624 YOL127W RPL25
SGTC_994 3910-0338 138 µM 0.583649337379928 0.265360245344357 no 909 0.279728129564581 1457 3479481
SGTC_2280 7785178 200 µM 0.581970296663353 0.265917187965152 no 910 0.280293344262394 1376 2954328
SGTC_2916 7875993 68.79 µM 0.581274133162126 0.266148280965673 no 911 0.28052785556871 1417 1299250
SGTC_778 3456-2434 196 µM 0.579322669352342 0.266796615236837 no 912 0.281185736056896 1448 5539063
SGTC_2639 lactacystin 53 µM 0.579196650112851 0.266838509990397 no 913 0.281228245454829 1412 3870 A proteasome inhibitor.
SGTC_2135 5326629 150.42 µM 0.576234196523191 0.267824326202137 no 914 0.282228446983533 1348 5020077
SGTC_1308 1187-1617 41.4 µM 0.576134758174758 0.267857448117406 no 915 0.28226204963676 1368 2882570
SGTC_2640 pentamidine 10.38 µM 0.576116092566382 0.267863665674105 no 916 0.282268357417567 1402 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2155 5570423 76 µM 0.575991397652738 0.26790520369898 no 917 0.282310498056519 1370 797402
SGTC_2347 9049783 174.81 µM 0.57481409963456 0.268297541797229 no 918 0.282708514987014 1414 6467988 YPL169C MEX67
SGTC_2716 st080858 38.6235 µM 0.574519961442785 0.26839560933941 no 919 0.28280799831412 1340 5296050
SGTC_183 3914-0051 30.55 µM 0.572318719754007 0.269130089068676 no 920 0.283553034914589 1428 1596232
SGTC_1725 st036284 20.55 µM 0.569783833078643 0.269977142351398 no 921 0.284412161020976 1492 707914
SGTC_2367 9070478 135.38 µM 0.568993609512589 0.270241474596233 no 922 0.28468023837993 1401 572802
SGTC_843 0310-0051 143 µM 0.568458824144338 0.270420435364127 no 923 0.284861728676426 1394 2065037
SGTC_809 3998-0021 90 µM 0.566886113933465 0.270947070644077 no 924 0.285395779516172 1342 715485
SGTC_448 monastrol 171 µM 0.566811061906772 0.270972215235297 no 925 0.285421277117141 1382 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_984 1492-0255 2.91 µM 0.566078485561536 0.271217710541648 no 926 0.285670213947714 1407 1585198
SGTC_3095 9117207 49.47 µM 0.563449593416581 0.272099596375137 no 927 0.286564387475761 1371 17015229
SGTC_2031 5180455 200 µM 0.562754981256662 0.272332848234896 no 928 0.286800869691311 1345 29949
SGTC_1826 st055655 41.6 µM 0.562720800305603 0.272344328816074 no 929 0.286812509057645 1428 676168
SGTC_308 4092-1169 104 µM 0.562307120362743 0.272483293284023 no 930 0.286953393933574 1397 2268590 YDL196W YDL196W
SGTC_804 1595-0054 20.9 µM 0.560623179801341 0.273049330207484 no 931 0.287527223096589 1377 761523 Stimulates phospholipase C.
SGTC_2243 6634756 200 µM 0.560425409123798 0.273115846734126 no 932 0.287594652143529 1479 885676
SGTC_740 k014-0057 261 µM 0.559597254125146 0.273394468611282 no 933 0.287877089120325 1467 4012779
SGTC_3112 9123419 49.47 µM 0.557465863255426 0.274112193683826 no 934 0.288604588118241 1415 17015854
SGTC_1774 st048371 48.465 µM 0.557072740337478 0.274244675597977 no 935 0.288738865712525 1356 4242727
SGTC_2182 6325192 200 µM 0.555775650252741 0.274682017426844 no 936 0.289182116673947 1356 736248
SGTC_3069 9117009 49.47 µM 0.555770392544263 0.274683790876035 no 937 0.289183914026759 1332 41904981
SGTC_194 1486-1323 56.904 µM 0.555635981508885 0.274729130252139 no 938 0.289229864354596 1372 5178754
SGTC_2948 9070189 9.45 µM 0.554423371563915 0.275138333178848 no 939 0.28964456741559 1393 6473636 YDL196W YDL196W
SGTC_2642 cholecalciferol 100 µM 0.554326127791937 0.275171161702437 no 940 0.28967783610591 1433 9821465 A vitamin D precursor, similar to steriods.
SGTC_3020 9089140 49.47 µM 0.552469045999454 0.275798463768529 no 941 0.29031351816318 1416 17217859
SGTC_1623 st003709 20.3 µM 0.552088874706942 0.275926968104429 no 942 0.290443731916768 1383 16192618
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.551815569205936 0.276019368160865 no 943 0.290537359595974 1325 88881 An O-methylated flavonoid and antioxidant.
SGTC_2965 9082772 38.63 µM 0.551453843902152 0.276141684844324 no 944 0.290661299416903 1461 16459634
SGTC_460 trequinsin 123 µM 0.550596723224239 0.276431624651408 no 945 0.290955077815531 1438 5537 A vasodilator.
SGTC_933 2914-0560 114 µM 0.549695108758137 0.276736776487661 no 946 0.291264256131954 1512 463887
SGTC_2641 levomentholum 100 µM 0.548772056401203 0.277049354860938 no 947 0.291580944630244 1370 16666
SGTC_3024 9090631 49.47 µM 0.547261807200371 0.277561151347575 no 948 0.292099439467937 1398 25236383
SGTC_1344 1488-0097 29.1 µM 0.547222996869745 0.277574309561788 no 949 0.292112769383608 1436 747966
SGTC_161 4065-0411 162.148 µM 0.54629915994269 0.277887616222676 no 950 0.292430156803879 1462 1906281 YLR208W SEC13
SGTC_694 1315-0438 43.2 µM 0.543920818144788 0.278694991665276 no 951 0.293247981210178 1443 6793154
SGTC_2246 7293507 91.5585 µM 0.543430859546249 0.278861459619525 no 952 0.293416591596269 1501 887656
SGTC_2708 st078559 56 µM 0.543026241388214 0.278998968838481 no 953 0.293555867465315 1368 17250902
SGTC_317 4495-0002 170 µM 0.542312741770682 0.279241531546497 no 954 0.293801539699008 1386 15991618
SGTC_190 3970-0790 3.722 µM 0.54216119909304 0.279293063480572 no 955 0.293853731128005 1465 2832352
SGTC_2765 myclobutanil 7.74 µM 0.541660884322037 0.279463227816247 no 956 0.294026070411659 1417 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2029 5175081 200 µM 0.541350427357489 0.279568844057747 no 957 0.294133034437151 1403 1380876
SGTC_2815 7968870 71.43 µM 0.540925147386846 0.279713554081937 no 958 0.294279588459761 1403 2977326 YHR190W ERG9
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.540342974042629 0.279911709133525 no 959 0.294480263544981 1334 6708630 An antioxidant.
SGTC_895 0964-0006 13.7 µM 0.539174660165026 0.28030957481835 no 960 0.294883171644192 1390 6738897
SGTC_121 0557-0495 61.343 µM 0.539090695079169 0.280338179415244 no 961 0.294912137869666 1486 3104427
SGTC_1024 4507-0395 26 µM 0.538964446896015 0.280381191361597 no 962 0.294955693360755 1463 4201836
SGTC_1158 4092-0494 91.8 µM 0.538957194868025 0.280383662178069 no 963 0.294958195392841 1515 1148199
SGTC_378 3970-0959 8.33 µM 0.538473716325716 0.280548410462769 no 964 0.29512502303938 1420 6615653
SGTC_2804 7954240 19.48 µM 0.536752016146104 0.281135470530288 no 965 0.295719460277752 1489 828705
SGTC_2829 7992743 58.44 µM 0.534832536078466 0.281790667676088 no 966 0.296382831207876 1480 16462845
SGTC_551 k048-0028 34.9 µM 0.532116159276002 0.282719134081937 no 967 0.297322773066127 1490 6836383
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.531324024855959 0.282990164759019 no 968 0.29759712985804 1526 1377
SGTC_3282 9108498 15.4605 µM 0.53058118412105 0.283244442761583 no 969 0.297854518658466 1411 16459645
SGTC_2710 st078562 53.7235 µM 0.529363331457925 0.283661556623031 no 970 0.298276715054854 1397 17250908
SGTC_1230 0170-0365 3.77 µM 0.529256953844692 0.283698004864484 no 971 0.29831360621669 1498 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_928 2764-0428 58.7 µM 0.527784602585938 0.284202707907903 no 972 0.298824422597661 1497 662578
SGTC_1360 1598-0022 39.8 µM 0.52744830618093 0.284318046181084 no 973 0.298941152744171 1517 761525
SGTC_988 1497-1057 103 µM 0.526914108250468 0.284501303952517 no 974 0.299126618057082 1486 3533044
SGTC_1118 chelidonine 707.474 nM 0.523440936018311 0.285694157124237 no 975 0.300333721634309 1533 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1398 3558-0053 112 µM 0.522714874970178 0.285943821526683 no 976 0.300586342624459 1415 4532369
SGTC_1337 1486-1011 40.3 µM 0.521477915360222 0.286369402942141 no 977 0.301016943155309 1441 X1337
SGTC_3129 9127257 49.47 µM 0.519464834763387 0.287062654318916 no 978 0.30171831456883 1346 837894
SGTC_1929 genistein trimethyl ether 50.5 µM 0.516036861059573 0.28824498276134 no 979 0.302914332284525 1593 136420
SGTC_2460 5552655 174.22 µM 0.515723775442633 0.288353082211984 no 980 0.303023673335138 1415 5401989
SGTC_2769 toremifene 3.73 µM 0.515168965370557 0.28854468909139 no 981 0.303217476846873 1475 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2831 7999036 19.48 µM 0.514174822217091 0.288888172175368 no 982 0.303564884565298 1628 2988270
SGTC_1862 st057513 3.81 µM 0.512997754251159 0.289295105622635 no 983 0.30397644580809 1450 5393163
SGTC_2469 5655019 90.81 µM 0.512630665913692 0.289422069711438 no 984 0.304104848939163 1573 2788239
SGTC_227 fluconazole 33.516 µM 0.512424822691003 0.289493275736138 no 985 0.304176861023668 1418 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3154 9100113 49.47 µM 0.510223292497027 0.290255351006588 no 986 0.304947517803417 1413 25237525
SGTC_866 0495-0101 262 µM 0.507584982507066 0.291169856581103 no 987 0.305872212270535 1409 635694
SGTC_3226 9131256 49.47 µM 0.506080854384088 0.291691827211295 no 988 0.306399945169304 1389 17178073
SGTC_945 3381-0768 11.3 µM 0.504046041545658 0.292398652166401 no 989 0.307114511563756 1481 1126236 YIL048W NEO1
SGTC_463 ikarugamyin 104 µM 0.503521738329776 0.292580906265075 no 990 0.307298750324209 1516 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3338 9144300 39.5675 µM 0.503267916758122 0.292669156651479 no 991 0.307387960029284 1504 4901274
SGTC_418 lividomycin a 100 µM 0.502764047111615 0.292844382054709 no 992 0.307565086945535 1475 72394 An antibiotic.
SGTC_381 3461-2219 42.7 µM 0.500322847063755 0.29369402105742 no 993 0.308423884644434 1554 2883159
SGTC_1378 2093-0007 380 nM 0.4983996798915 0.294364165481445 no 994 0.309101181179393 1510 3618014
SGTC_338 4055-0136 114 µM 0.496981581576216 0.294858766051778 no 995 0.309601019886331 1445 2900563
SGTC_2551 apiole 73.87 µM 0.496940808359075 0.294872992489771 no 996 0.309615396483319 1452 10659 A possible DNA adduct former.
SGTC_1822 st052468 42 µM 0.495277588689382 0.295453586324164 no 997 0.310202094229473 1448 2873678
SGTC_2363 9053361 176 µM 0.494877509102041 0.295593323824846 no 998 0.310343293769537 1601 6469797 YMR079W SEC14
SGTC_2172 5754775 163.918 µM 0.49478865920306 0.295624360929863 no 999 0.310374655237161 1427 2263357
SGTC_410 α-linolenic acid 100 µM 0.49223880606903 0.296515714943585 no 1000 0.311275267119619 1536 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_552 k242-0005 476 µM 0.492057094035758 0.296579283131691 no 1001 0.311339491305227 1485 4088318
SGTC_1262 0737-0114 49.6 µM 0.491280023798684 0.296851195453318 no 1002 0.311614203285208 1520 765919
SGTC_3176 9106582 49.47 µM 0.490766028952343 0.297031115135912 no 1003 0.311795969784248 1450 17018027
SGTC_1770 st043884 66.3 µM 0.490043659178629 0.297284059020868 no 1004 0.31205150242514 1485 670149
SGTC_2638 epoxomicin 18 µM 0.489934464450513 0.297322303040508 no 1005 0.312090137077794 1581 9915668 A protesome inhibitor.
SGTC_562 3772-2733 112 µM 0.488246914474674 0.29791363084308 no 1006 0.312687478927975 1497 2876874 YIL048W NEO1
SGTC_1513 0337-0559 19 µM 0.486736617604741 0.2984433022848 no 1007 0.313222496074762 1439 775073
SGTC_3065 9113888 49.47 µM 0.486703151264488 0.298455044010782 no 1008 0.313234355862653 1543 16648368
SGTC_3339 9145883 14.936 µM 0.48635165357088 0.298578380307813 no 1009 0.313358931138176 1537 2030670
SGTC_2782 7736369 71.43 µM 0.483719205301508 0.299502810598857 no 1010 0.314292580689528 1511 2950836 YOL077C BRX1
SGTC_2848 9016370 25.97 µM 0.48353497802212 0.299567553780521 no 1011 0.314357965115377 1570 7894410
SGTC_3084 9116877 49.47 µM 0.481911120532612 0.3001385018083 no 1012 0.314934542968755 1483 27241325
SGTC_529 4076-0302 30.3 µM 0.481536053380156 0.300270445285072 no 1013 0.315067781066769 1484 5816522
SGTC_2738 aclarubicin 5.55 µM 0.481210814666805 0.300384881021547 no 1014 0.315183337693813 1534 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3298 9116858 71.43 µM 0.480928795679006 0.300484125780371 no 1015 0.315283553085531 1575 2506942
SGTC_1088 bifonazole 369 nM 0.480755909490955 0.300544973147216 no 1016 0.315344994879509 1479 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2014 4013930 200 µM 0.479912052371201 0.300842048839655 no 1017 0.315644965419027 1470 64556
SGTC_642 0335-0876 158 µM 0.479301945569459 0.301056916364029 no 1018 0.315861919135964 1540 6812350
SGTC_2402 5553605 200 µM 0.478960375982921 0.301177240596947 no 1019 0.315983408844283 1592 6758546
SGTC_608 k048-0125 159 µM 0.478318047824114 0.30140357128319 no 1020 0.316211926398215 1556 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2606 farnesol 9.78 µM 0.477041129890461 0.30185373318303 no 1021 0.316666416942418 1589 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1980 st071811 45.7 µM 0.476844458117894 0.301923094270167 no 1022 0.316736442512433 1556 4974850
SGTC_26 0302-0163 425.158 µM 0.476196574940864 0.30215163667104 no 1023 0.316967169686917 1535 3100915
SGTC_1506 4226-2149 212 µM 0.473531750816664 0.303092475483905 no 1024 0.31791692709378 1562 991114
SGTC_1305 1181-0477 144 µM 0.473368835712465 0.303150036532062 no 1025 0.31797502985034 1608 6252086
SGTC_2343 7990716 14.84 µM 0.471807566387063 0.30370191082897 no 1026 0.318532074848636 1556 6456862
SGTC_2687 chenodiol 100 µM 0.471639307378763 0.303761413436956 no 1027 0.318592132470975 1560 5702181 A cholesterol synthesis inhibitor.
SGTC_1340 1486-1359 257 µM 0.469573291334921 0.304492456762941 no 1028 0.319329955205878 1540 4309068
SGTC_1346 1488-2224 62.4 µM 0.469039452047393 0.304681478750614 no 1029 0.319520718250971 1569 3722427
SGTC_1741 st038134 10.228 µM 0.468729153810932 0.304791373223878 no 1030 0.319631622710643 1649 1272587
SGTC_1622 st003707 19.4 µM 0.468676961010126 0.304809859430857 no 1031 0.319650278653711 1555 10140899
SGTC_3164 9100705 49.47 µM 0.46651193710529 0.305577129470866 no 1032 0.320424552572842 1592 17174235
SGTC_559 1550-0661 158 µM 0.465153711207562 0.306058912153609 no 1033 0.320910692226953 1595 5830875
SGTC_671 0560-0003 407 µM 0.464484863504535 0.306296285670718 no 1034 0.321150200833757 1567 3238678
SGTC_880 0833-0487 87.2 µM 0.463810201370377 0.306535805119306 no 1035 0.321391866930905 1506 76075
SGTC_3063 1327-0034 4 µM 0.463659042425951 0.306589481107747 no 1036 0.321446022914168 1495 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_137 0438-0332 85.389 µM 0.462295159868363 0.307073978307047 no 1037 0.321934835052773 1500 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1375 2910-0797 186 µM 0.460800265643674 0.307605402463631 no 1038 0.322470955568487 1573 742508
SGTC_2424 5537928 59.2 µM 0.458999354154799 0.308246150056663 no 1039 0.323117314933108 1520 5382802
SGTC_222 nsc-310342 10.666 µM 0.458292890473771 0.308497663067489 no 1040 0.323371015604125 1618 432556
SGTC_281 1672-3440 14.9 µM 0.457215036169186 0.308881570593083 no 1041 0.32375824592948 1575 6833000
SGTC_2224 6650123 117.647 µM 0.456745470179995 0.309048884818192 no 1042 0.323927002088075 1543 2908370
SGTC_2737 bleomycin 30.5 nM 0.454824232908407 0.309733866230039 no 1043 0.324617847511733 1556 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2380 9035439 200 µM 0.454238694646521 0.30994276059023 no 1044 0.324828517644776 1612 6462575
SGTC_331 k048-0133 24.5 µM 0.453496254134254 0.310207719028936 no 1045 0.325095720026621 1528 6813582
SGTC_2 0422-0095 29 µM 0.453192822287815 0.310316034639792 no 1046 0.325204950256477 1493 6790840
SGTC_1434 4073-0095 163 µM 0.452159988893333 0.310684846910951 no 1047 0.325576864998652 1560 24133745
SGTC_2126 5251174 33.877 µM 0.45143720837561 0.310943056291971 no 1048 0.325837235615922 1722 790722
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.451089079310256 0.311067456724882 no 1049 0.325962674108412 1641 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1572 epiandrosterone 68.9 µM 0.450993828852287 0.311101497283657 no 1050 0.325996998358085 1588 441302 A steroid.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.450820198310861 0.311163553433151 no 1051 0.326059571279231 1581 7104
SGTC_2840 9008771 71.43 µM 0.450401990927831 0.311313044216418 no 1052 0.326210304831377 1691 2992978
SGTC_2210 7115885 190.385 µM 0.450140990037775 0.311406356352909 no 1053 0.326304391190488 1550 2927039
SGTC_847 0342-0274 5.54 µM 0.449599550090671 0.311599968728223 no 1054 0.326499606282454 1662 18097
SGTC_2023 5144124 124 µM 0.449534875512156 0.311623099059485 no 1055 0.326522927751121 1526 2830192
SGTC_1040 k898-0338 155 µM 0.448427984868327 0.312019084561626 no 1056 0.326922174404773 1731 20969351
SGTC_1831 st055328 12 µM 0.44821673160603 0.312094684244868 no 1057 0.326998394314099 1647 1103068
SGTC_1516 st013856 110 µM 0.447544821212551 0.312335188583125 no 1058 0.327240866703417 1538 5281404 A mutagen and neurotoxin.
SGTC_477 mead ethanolamide 10 µM 0.445509873333736 0.313064067611843 no 1059 0.32797566312095 1514 16061185
SGTC_875 0709-0210 25.7 µM 0.445498908613194 0.313067996945784 no 1060 0.327979624163579 1606 6251364
SGTC_1841 st054148 70 µM 0.445280014885138 0.313146444477232 no 1061 0.328058704316408 1506 675442
SGTC_2315 7733312 200 µM 0.445266551365904 0.31315126983383 no 1062 0.328063568559238 1524 726316
SGTC_3354 9151612 71.43 µM 0.445170805843798 0.313185586174404 no 1063 0.328098161356578 1652 27261949
SGTC_1672 st016598 6.51 µM 0.443769160320184 0.313688137784291 no 1064 0.328604743666421 1510 4665860 YNL267W PIK1
SGTC_399 oxolinic acid 75 µM 0.442245125474505 0.314234963930263 no 1065 0.329155917543239 1537 4628 A DNA gyrase inhibitor.
SGTC_2686 alizarin 95.37 µM 0.440906806996849 0.314715491257772 no 1066 0.329640232763986 1503 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1133 3473-0247 50 µM 0.440867260456294 0.314729695342915 no 1067 0.329654548351774 1492 711311
SGTC_791 1348-1292 225 µM 0.438566231314622 0.31555663639676 no 1068 0.330487934947713 1648 5437054
SGTC_929 2805-0021 398 µM 0.438168573557573 0.315699639959168 no 1069 0.330632043982655 1618 3098024
SGTC_2281 7943571 200 µM 0.437469802966207 0.315950994958086 no 1070 0.330885335513821 1673 1244024
SGTC_2709 st078560 56 µM 0.437284424019216 0.316017691970092 no 1071 0.330952544985694 1686 17250903
SGTC_440 fluspirilene 35.1 µM 0.435979595767472 0.316487322082641 no 1072 0.331425766859624 1661 3396 An atypical antipsychotic.
SGTC_1716 st033144 30.6155 µM 0.435101258737481 0.316803617446129 no 1073 0.331744464905507 1678 674617
SGTC_2932 9016711 44.54 µM 0.434997097842348 0.316841135408909 no 1074 0.331782266993723 1709 7117328
SGTC_2846 9008642 19.48 µM 0.433353190144163 0.317433507722645 no 1075 0.332379100850003 1560 2992898
SGTC_1047 2043-3044 82 µM 0.431582329700022 0.318072150196907 no 1076 0.333022501749579 1518 669592
SGTC_3162 9099653 49.47 µM 0.428687414927845 0.319117336461483 no 1077 0.334075360252523 1607 25237511
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.428442724390393 0.319205746154511 no 1078 0.334164412367064 1624 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3264 9137442 49.47 µM 0.427680648633649 0.319481159339336 no 1079 0.334441820274315 1662 17015726
SGTC_680 0417-1641 114 µM 0.42691367015655 0.319758444938538 no 1080 0.33472110415426 1563 2835990
SGTC_2704 st078022 71.1 µM 0.42645477816957 0.319924396272041 no 1081 0.33488824663152 1720 54697681
SGTC_1044 1222-0021 1.78 µM 0.426381553567907 0.319950880175135 no 1082 0.334914920295032 1610 4306703
SGTC_3007 9078383 71.4286 µM 0.425121775233323 0.320406660913652 no 1083 0.335373952436375 1590 6496995
SGTC_2953 9074162 66.49 µM 0.425114489391357 0.320409297679298 no 1084 0.335376607933191 1740 16451992
SGTC_734 2023-0417 80 µM 0.425012797105104 0.320446101335277 no 1085 0.335413672942088 1633 3935732
SGTC_732 3970-1727 52.7 µM 0.424968466631221 0.320462145617237 no 1086 0.335429831103729 1714 1275699
SGTC_770 0389-1121 67.2 µM 0.423879795780789 0.320856267444886 no 1087 0.335826739824835 1707 6753108
SGTC_508 roscovitine 141 µM 0.423733117668142 0.320909383466404 no 1088 0.335880229892506 1646 160355 A CDKinase inhibitor.
SGTC_32 0928-0142 34.1 µM 0.423035322253477 0.321162123814738 no 1089 0.336134745028808 1618 2244242
SGTC_999 SEC7.066 22.7 µM 0.422744080053446 0.321267635775007 no 1090 0.336240995456989 1644 740511 YDR170C SEC7
SGTC_2226 7298446 200 µM 0.422619147947253 0.321312900916513 no 1091 0.336286576961533 1664 3283010
SGTC_2437 5741531 144.16 µM 0.420532138171592 0.322069454053514 no 1092 0.337048378365723 1718 2262990
SGTC_2271 7849410 118.62 µM 0.419943707221651 0.322282897181283 no 1093 0.337263288741979 1718 972430
SGTC_2088 5278280 127.392 µM 0.419549380811749 0.322425965055302 no 1094 0.337407336788266 1622 791502
SGTC_1996 st072960 66.8 µM 0.419261625180601 0.322530383963114 no 1095 0.337512469407443 1666 1719405
SGTC_3042 9091578 49.47 µM 0.417824597451199 0.323052052716606 no 1096 0.338037682678367 1603 25236497
SGTC_80 0159-0065 512.242 µM 0.417800533307546 0.323060791431841 no 1097 0.338046480469781 1617 1548079
SGTC_813 k007-0158 173 µM 0.417642419383874 0.323118211758979 no 1098 0.338104288729035 1704 6523916
SGTC_1315 1237-0019 3.69 µM 0.416923669744248 0.323379284513016 no 1099 0.338367119920907 1682 825140
SGTC_2685 mycophenolic acid 18.85 µM 0.415942465792504 0.323735829449168 no 1100 0.338726052124781 1648 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1270 0831-1170 17.3 µM 0.413845794844753 0.324498249213238 no 1101 0.339493521708504 1587 6764716
SGTC_3059 1327-0034 3 µM 0.412679075686139 0.324922826393408 no 1102 0.339920878589256 1565 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2597 laccaic acid a 100 µM 0.412449499973743 0.32500639738892 no 1103 0.340004993991799 1617 5491415 A textile dye.
SGTC_216 k038-0035 28.382 µM 0.411768051481194 0.325254512624273 no 1104 0.340254720236817 1653 4444231 YPR107C YTH1
SGTC_2955 9076254 12.21 µM 0.410682827504945 0.325649802348187 no 1105 0.340652560238793 1713 16459619
SGTC_174 3553-0389 74.3 µM 0.409369120875751 0.326128578632434 no 1106 0.341134398579892 1653 738071
SGTC_2433 5607874 27.82 µM 0.409198504521918 0.326190780285158 no 1107 0.341196995891853 1560 2252428
SGTC_2158 5657123 3.6195 µM 0.40858465232052 0.326414612541886 no 1108 0.341422247824645 1637 2858827
SGTC_390 dec-rvkr-cmk 16.7 µM 0.408548651480898 0.326427741664895 no 1109 0.341435460021052 1638 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.406077124079538 0.327329594784647 no 1110 0.342342966749017 1654 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2084 5306078 60.6385 µM 0.405701868287833 0.327466612866176 no 1111 0.342480834682748 1670 679340
SGTC_2983 9022671 12.99 µM 0.404674116010532 0.327841997577523 no 1112 0.342858535433386 1756 6405161
SGTC_1166 k206-0078 225 µM 0.403179470461446 0.32838822473043 no 1113 0.343408100583062 1587 5404595
SGTC_798 1287-0182 476 µM 0.40163750440065 0.328952130123133 no 1114 0.34397541213799 1750 1649755
SGTC_421 streptovitacin 30 mM 0.40134881778484 0.329057747721367 no 1115 0.344081663200737 1620 91467 include heat shock
SGTC_1287 0971-0001 34.6 µM 0.400535543456391 0.32935536199991 no 1116 0.344381054858245 1658 4665869
SGTC_2913 7966556 36.57 µM 0.399474636434766 0.329743758948078 no 1117 0.344771754425095 1730 2976516
SGTC_3100 9120536 49.47 µM 0.399341764389148 0.329792416215308 no 1118 0.344820698808114 1694 16421196
SGTC_158 k038-0087 26.446 µM 0.397909360829477 0.330317140031146 no 1119 0.345348499823849 1654 X158
SGTC_2196 6573537 42.6665 µM 0.396973526086202 0.330660139144734 no 1120 0.34569349156917 1719 2903087
SGTC_1754 st042065 16.137 µM 0.38931718475432 0.333471637217798 no 1121 0.348520762761059 1613 1126236 YIL048W NEO1
SGTC_1048 3161-0300 24.5 µM 0.387087098927126 0.334292321902412 no 1122 0.349345864080785 1595 2165101
SGTC_2354 9060492 162 µM 0.38666336325363 0.334448348860517 no 1123 0.349502721163168 1746 6471895
SGTC_1962 st076595 64.5 µM 0.386021810168393 0.334684634462 no 1124 0.349740258088725 1648 279619
SGTC_1657 st012939 43.4 µM 0.385523686280408 0.334868139895692 no 1125 0.349924730508963 1743 24207257
SGTC_248 streptozotocin 5.23457 mM 0.384410312058569 0.335278441874311 no 1126 0.350337179339297 1739 5300 DNA alkylating agent.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.384228264914284 0.335345548814366 no 1127 0.350404635404221 1629 390807
SGTC_1699 st031318 29.054 µM 0.383300883103479 0.335687485493453 no 1128 0.350748342273789 1706 5340658
SGTC_3132 9126706 49.47 µM 0.38285023576192 0.335853693670012 no 1129 0.350915405627384 1687 850858
SGTC_600 1495-0418 41.6 µM 0.382849368969109 0.335854013392302 no 1130 0.35091572699139 1655 5377768
SGTC_2739 tacrine 100.86 µM 0.382560546510253 0.335960554089491 no 1131 0.351022814045299 1658 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_865 0488-0499 301 µM 0.381893838445743 0.336206539380408 no 1132 0.351270055375099 1686 9634651
SGTC_1032 k061-1018 98.7 µM 0.381811334010006 0.336236984686126 no 1133 0.351300655614306 1808 4005393
SGTC_733 4069-0007 56.1 µM 0.381262283329771 0.336439619515673 no 1134 0.351504318690024 1690 5717425 YNL287W SEC21
SGTC_815 1582-0027 36.9 µM 0.381211445366031 0.336458384381244 no 1135 0.351523178516689 1699 3128206
SGTC_1828 st055811 49 µM 0.380910849142789 0.336569346159651 no 1136 0.351634700928978 1774 5877589
SGTC_1143 3454-2408 5.08 µM 0.380467504606854 0.336733027875686 no 1137 0.351799206845516 1648 X1143
SGTC_846 0335-0850 148 µM 0.379993512839206 0.336908058688274 no 1138 0.3519751153137 1665 6819598
SGTC_1356 1502-0781 85.8 µM 0.379608808494759 0.337050144329491 no 1139 0.352117910609026 1668 567702
SGTC_3003 9075612 71.4286 µM 0.37840715340916 0.337494109968312 no 1140 0.352564077471858 1667 6501993
SGTC_3049 9092223 49.47 µM 0.378155746131527 0.337587023997668 no 1141 0.352657449076583 1668 8623917
SGTC_2541 muurolladie-3-one 83.07 µM 0.378018722306922 0.337637668847624 no 1142 0.352708342886357 1685 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2810 7959871 45.46 µM 0.377727570516906 0.337745290104472 no 1143 0.352816492129345 1736 2974535
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.376497580963039 0.338200089394969 no 1144 0.353273506767279 1624 803109
SGTC_2894 9048625 32.47 µM 0.376437693788923 0.338222239231648 no 1145 0.353295763841181 1777 4092861
SGTC_1644 st010134 20.9 µM 0.374318788176302 0.339006296357464 no 1146 0.35408357775193 1751 3818134
SGTC_587 k089-0003 57 µM 0.374034200492917 0.339111655366437 no 1147 0.354189435780919 1731 9659696
SGTC_2531 methyl deoxycholate 70.07 µM 0.37375663539825 0.339214426619793 no 1148 0.354292692473953 1608 16667744 Haematoxylin.
SGTC_910 3454-3003 490 µM 0.373500058926339 0.339309437266245 no 1149 0.354388150740247 1730 820824
SGTC_2519 cryptotanshinone 88.04 µM 0.373465374484566 0.339322281750308 no 1150 0.354401055652316 1739 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2076 5212012 200 µM 0.373398810430526 0.339346932545464 no 1151 0.354425822362137 1661 604802
SGTC_155 k072-0202 43.6 µM 0.373293389028359 0.339385974864314 no 1152 0.354465048114668 1731 5857737
SGTC_2669 eugenol 100 µM 0.372237241756082 0.33977720912149 no 1153 0.354858110112028 1766 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_897 1000-0139 31.4 µM 0.372106481683324 0.339825659291769 no 1154 0.354906785311881 1779 6151020
SGTC_3018 9082602 49.47 µM 0.370454557178003 0.340437969980317 no 1155 0.355521914932475 1683 17332089
SGTC_3043 9092303 49.47 µM 0.369206764958371 0.34090076207395 no 1156 0.355986806921179 1591 25236084
SGTC_2369 9071472 200 µM 0.368908727144088 0.341011336409088 no 1157 0.356097879075123 1729 17296037
SGTC_1428 4049-0204 61.7 µM 0.367841561839735 0.341407374937951 no 1158 0.356495688264227 1767 X1428
SGTC_2839 9003951 25.97 µM 0.367111029911704 0.341678585330567 no 1159 0.356768100085717 1723 2990634
SGTC_521 r062-0005 13.8 µM 0.36686446732082 0.341770140290921 no 1160 0.356860058581313 1647 2832033
SGTC_2742 clothiapine 36.27 µM 0.363688244974287 0.342950383002138 no 1161 0.358045411134575 1779 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2919 7978188 46.38 µM 0.36292413379617 0.343234546089597 no 1162 0.358330778985131 1810 2980291
SGTC_1417 3966-0327 90.4 µM 0.362418115078023 0.343422776730263 no 1163 0.358519802220558 1694 651118
SGTC_1267 0828-0272 9.49 µM 0.362385008741493 0.343435093097169 no 1164 0.358532170297597 1793 745334
SGTC_2163 5671233 125 µM 0.361157343277033 0.343891931967667 no 1165 0.358990914090506 1783 701023
SGTC_911 3456-4043 236 µM 0.35970839891986 0.344431406471389 no 1166 0.359532605239998 1752 914281
SGTC_2221 6807166 181.081 µM 0.356354331755011 0.345681414226433 no 1167 0.36078761270071 1740 674925
SGTC_2899 9053889 58.44 µM 0.355760643401851 0.345902848319897 no 1168 0.36100991263168 1809 6470052
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.354085230867361 0.346528028360626 no 1169 0.361637505038545 1780 688662
SGTC_2457 5731572 11.68 µM 0.35370356632227 0.346670505007376 no 1170 0.361780524813543 1816 2865357
SGTC_1235 benzylparaben 21.5 µM 0.353668201115232 0.346683708055333 no 1171 0.36179377806744 1709 7180
SGTC_2448 5185112 27.17 µM 0.352902210335215 0.346969724427653 no 1172 0.362080876853904 1684 5718189
SGTC_64 000l-0018 272.079 µM 0.352782710597273 0.347014352782587 no 1173 0.362125673207526 1669 6811119
SGTC_3306 9127676 59.7925 µM 0.352263369001696 0.347208330664718 no 1174 0.362320378492679 1665 41905287
SGTC_2492 derrusnin 100 µM 0.352019347902497 0.347299488156852 no 1175 0.362411876243441 1665 1715307 Part of coumarin class of compounds.
SGTC_15 0266-0086 27.098 µM 0.350447323065877 0.347886951572171 no 1176 0.363001508306712 1792 1712902 YIL048W NEO1
SGTC_2046 4110841 106 µM 0.350385619067904 0.347910017727626 no 1177 0.363024658759537 1797 44119630 YMR134W ERG29
SGTC_2072 5231554 129 µM 0.350112782061462 0.348012016256675 no 1178 0.363127029279862 1857 789545
SGTC_1059 3448-6867 171 µM 0.348791324372764 0.348506191042798 no 1179 0.363622988521916 1840 3934407
SGTC_2657 nystatin 74.44 µM 0.347732319791662 0.348902404090881 no 1180 0.364020610976636 1752 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_115 0527-0192 112.043 µM 0.346316441321359 0.34943239437932 no 1181 0.364552456925438 1704 4233931
SGTC_3166 9102297 49.47 µM 0.344131854859841 0.350250702563758 no 1182 0.365373563788114 1670 25237072
SGTC_1875 nocodazole 6 µM 0.342419477800708 0.35089261591842 no 1183 0.366017616159446 1830 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_224 benfluorex 43.875 µM 0.342246085909532 0.350957638558079 no 1184 0.366082852709694 1816 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3310 9130229 44.1445 µM 0.34073701714988 0.351523729379307 no 1185 0.366650784410931 1801 7761258
SGTC_989 1501-0895 10.3 µM 0.340260124199139 0.351702692858161 no 1186 0.366830321868581 1852 2830112
SGTC_3127 9126946 49.47 µM 0.340246150215389 0.35170793736683 no 1187 0.366835583139754 1646 27243249
SGTC_2396 5342950 42.78 µM 0.338854110959834 0.352230518211705 no 1188 0.367359817738205 1699 1886677
SGTC_1079 idarubicin 2.36 µM 0.338307038690122 0.352435969263287 no 1189 0.367565910005244 1800 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_950 1165-0508 94.1 µM 0.338057707122676 0.352529619138301 no 1190 0.367659850487352 1667 6148369
SGTC_300 r073-0011 5.04 µM 0.337680273937312 0.352671401470487 no 1191 0.367802070791747 1760 2735780
SGTC_2661 dactinomycin 12.96 µM 0.336652975550454 0.35305740851919 no 1192 0.368189258059251 1739 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2838 9002687 71.43 µM 0.333724672369953 0.354158546479923 no 1193 0.369293665028823 1655 6457060
SGTC_1628 st004252 77.7 µM 0.333529862888332 0.354231844631263 no 1194 0.369367175653719 1834 692968
SGTC_315 k915-0449 187 µM 0.332390169908448 0.35466076859592 no 1195 0.369797330143034 1778 20970215 YNL149C PGA2
SGTC_1876 myriocin 605 nM 0.331908178661545 0.354842221715297 no 1196 0.369979297238234 1844 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2799 7812892 81.82 µM 0.331439934245091 0.355018531166089 no 1197 0.370156102345276 1836 20205235
SGTC_2099 5377090 177.372 µM 0.331206429792692 0.355106464890768 no 1198 0.370244281895946 1707 2243829
SGTC_1793 st048256 72.231 µM 0.330852481985188 0.355239770206196 no 1199 0.370377958125336 1736 672022
SGTC_1984 st072354 53.1 µM 0.33022048218401 0.355477840686614 no 1200 0.370616685772022 1755 5762938
SGTC_2907 7721985 69.9 µM 0.329883393262164 0.355604843102531 no 1201 0.370744036011306 1680 3267881
SGTC_1068 loratadine 26.9 µM 0.329422444310136 0.355778537264173 no 1202 0.370918202772726 1706 3957 A H1 histamine antagonist.
SGTC_3240 9133527 49.47 µM 0.328788659034999 0.356017408264313 no 1203 0.371157717865838 1742 17617455
SGTC_1146 3579-1023 7 µM 0.328601368959025 0.356088007929621 no 1204 0.371228506601185 1862 X1146
SGTC_1320 1313-0481 95.3 µM 0.328332913334868 0.356189211843966 no 1205 0.371329980515115 1862 6813365 YLR208W SEC13
SGTC_2296 7971656 126.45 µM 0.327684624109954 0.356433649332257 no 1206 0.371575065127233 1696 666570
SGTC_486 niguldipine 82 µM 0.325502431207381 0.357256878253109 no 1207 0.372400421443986 1767 1236 A calcium channel blocker.
SGTC_1559 coumarin 343 70.1 µM 0.324882042743565 0.357491040391255 no 1208 0.37263517406739 1800 108770 A hepatotoxic, DNA x-linker.
SGTC_3021 9087658 49.47 µM 0.324126166589582 0.357776414111226 no 1209 0.37292125865667 1825 25237042
SGTC_1882 5615643 20 µM 0.323736648604847 0.357923503908978 no 1210 0.373068711102238 1764 2253075
SGTC_17 0960-0276 49.807 µM 0.32323450477864 0.358113154607028 no 1211 0.373258825613843 1764 6821114
SGTC_790 1575-0012 79.1 µM 0.320042345223191 0.359319592994554 no 1212 0.374468115253201 1874 378741 YLR208W SEC13
SGTC_2967 9089538 49.85 µM 0.31945081008213 0.359543311142492 no 1213 0.374692343301891 1927 728216
SGTC_464 bw-b 70c 158 µM 0.316438262291805 0.360683400005521 no 1214 0.375834939369324 1843 5353454
SGTC_1227 3909-8010 46.6 µM 0.313683575330885 0.361726987489953 no 1215 0.376880688291919 1772 15982272
SGTC_2186 6124449 200 µM 0.312540943254495 0.362160165458864 no 1216 0.377314726033862 1834 3834182 YLR033W RSC58
SGTC_2735 sertaconazole 140 nM 0.312245504200096 0.362272196749528 no 1217 0.377426976117338 1849 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3224 9130643 49.47 µM 0.31177132884641 0.362452029989265 no 1218 0.377607157500926 1815 17644395
SGTC_1682 st012968 530 nM 0.311275396427743 0.362640147174057 no 1219 0.377795634828129 1691 24207270
SGTC_537 1334-0398 209 µM 0.311193985592938 0.362671031118196 no 1220 0.377826577503776 1902 5846986
SGTC_226 1,3-diallylurea 8.28947 mM 0.30775404202187 0.363976819327521 no 1221 0.379134747231465 1793 74537 YKL182W FAS1
SGTC_2933 9026794 32.47 µM 0.307639260316364 0.36402041732362 no 1222 0.37917842131898 1808 17586027
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.306226520764831 0.364557167851552 no 1223 0.379716090536888 1916 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2951 9072950 58.06 µM 0.305795027070156 0.364721160822624 no 1224 0.379880357521769 1855 16488155
SGTC_2863 9028737 58.44 µM 0.30093768534335 0.366568937676965 no 1225 0.38173100639454 1906 6460917
SGTC_2342 7990637 118.86 µM 0.300492399008462 0.366738484245945 no 1226 0.381900796706289 1793 2033102 YER133W GLC7
SGTC_718 1130-0073 349 µM 0.300134747738701 0.366874681848752 no 1227 0.382037187704214 1842 6740020
SGTC_1072 oxiconazole 14.9 nM 0.29933676976084 0.367178621174845 no 1228 0.382341550890637 1808 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1397 3532-0190 20.1 µM 0.298649430457423 0.367440486431413 no 1229 0.38260377278586 1812 5322280
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.297908581249931 0.367722807145212 no 1230 0.382886469140331 1796 3256 An antibiotic and ribosome inhibitor.
SGTC_2570 licareol 100 µM 0.29757152441395 0.367851275478095 no 1231 0.383015105365628 1751 443158
SGTC_2627 acetyl isogambogic acid 100 µM 0.296861912672432 0.368121790453151 no 1232 0.38328596765551 1702 6857789 A caspase activator and apoptosis inducer.
SGTC_265 mycophenolic acid 32.932 µM 0.29495949573491 0.368847343612492 no 1233 0.384012410774889 1892 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1213 1315-0166 115 µM 0.29382144011032 0.369281604625439 no 1234 0.384447175505867 1670 768401
SGTC_85 0868-0259 160.055 µM 0.293103164999729 0.369555771072278 no 1235 0.384721648821024 1810 83173
SGTC_1285 0929-0069 65.5 µM 0.29144238719987 0.37018994571416 no 1236 0.385356500248863 1802 1206237
SGTC_819 1013-0258 27.7 µM 0.290497223518912 0.370551017997286 no 1237 0.385717937280024 1792 5753198
SGTC_19 0279-0214 38.434 µM 0.290015113541367 0.370735238034873 no 1238 0.385902337664005 1823 3566274 YBR002C RER2
SGTC_806 3966-4455 5.86 µM 0.289870837875906 0.370790373270632 no 1239 0.385957526120749 1735 714982
SGTC_221 trifluoperazine 10.304 µM 0.28768723557764 0.371625164644347 no 1240 0.386793080841983 1803 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1654 st012436 41.8 µM 0.28751011008526 0.371692906276762 no 1241 0.386860880926746 1901 4323132
SGTC_1062 mesoridazine 14.2 µM 0.286354144451701 0.372135102744781 no 1242 0.387303446088987 1797 4078 A neuroleptic.
SGTC_1692 fluoroquinolonic acid 71 µM 0.286266672799418 0.37216857052127 no 1243 0.387336940862376 1844 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1916 st067606 49.2 µM 0.283787186313577 0.373117654616273 no 1244 0.388286737419929 1897 19590279
SGTC_344 k064-0035 6.43 µM 0.283437422178178 0.373251597532719 no 1245 0.388420772629175 1734 5088750
SGTC_1022 4477-0945 21.3 µM 0.283292432893134 0.373307125978515 no 1246 0.388476338738359 1758 4648966
SGTC_3098 9119039 49.47 µM 0.282877563777251 0.373466028370785 no 1247 0.38863534697269 1799 17161528
SGTC_3239 9133757 49.47 µM 0.282435013371474 0.373635556917829 no 1248 0.388804985275496 1873 17036923
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.281796466814895 0.373880209139409 no 1249 0.389049790133228 1758 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2043 5101342 149 µM 0.281739970127989 0.373901857683758 no 1250 0.389071451856528 1833 678451
SGTC_275 trichlorophene 5.69 µM 0.281417188053623 0.374025549767321 no 1251 0.389195218219389 1830 62616
SGTC_1846 st056244 14.8 µM 0.281243921717453 0.374091951848339 no 1252 0.389261659459598 1861 5393182
SGTC_2288 7946289 167.31 µM 0.280429181678959 0.374404240481515 no 1253 0.389574125548608 1919 1246052
SGTC_2564 betulinic acid 100 µM 0.280186539224472 0.37449726090608 no 1254 0.389667196693107 2018 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2001 4023502 57.655 µM 0.277237265158362 0.37562848943806 no 1255 0.390798963583201 1842 108941 YCR052W RSC6
SGTC_2818 7996756 12.99 µM 0.276665111106239 0.375848070036984 no 1256 0.391018631898488 1794 2241621
SGTC_1712 st032288 53.4 µM 0.276289849958458 0.375992109151439 no 1257 0.391162725592441 1825 2883011
SGTC_1106 tegaserod maleate 11.7 µM 0.275515259901863 0.37628948009862 no 1258 0.391460201804987 1848 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2788 5282734 71.43 µM 0.275428616123784 0.376322747867291 no 1259 0.391493480728883 1923 743706
SGTC_2217 6934799 96.0675 µM 0.275013438024955 0.37648217250957 no 1260 0.391652957094813 1910 675606
SGTC_1989 st071868 50.2 µM 0.273811297840512 0.376943902238695 no 1261 0.39211482044641 1956 16414057
SGTC_188 3229-0966 278.469 µM 0.273453789993652 0.377081251331079 no 1262 0.392252204647511 1939 5722370
SGTC_3327 9140648 26.9345 µM 0.273149211652027 0.377198277981354 no 1263 0.392369259534184 1929 8029710
SGTC_578 3460-0051 92 µM 0.272715387235521 0.377364983692484 no 1264 0.392536002803736 1955 2876744
SGTC_629 3448-6466 76.7 µM 0.272679586006846 0.377378742052079 no 1265 0.392549764123218 1836 573744
SGTC_3194 9111903 49.47 µM 0.272591733511561 0.377412504296462 no 1266 0.392583533540649 1873 17087251
SGTC_1076 itraconazole 331 nM 0.272503496808833 0.377446415137134 no 1267 0.392617451456718 1898 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2811 7967822 32.47 µM 0.272225617170921 0.377553215101827 no 1268 0.392724272858819 1883 2232244
SGTC_1895 st058434 18.3 µM 0.271988491135278 0.377644359274833 no 1269 0.392815434311149 1960 5393175
SGTC_2511 berberine 10.47 µM 0.271856588478046 0.37769506167018 no 1270 0.392866145914007 1796 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_220 paclitaxel 373.376 µM 0.270276602799839 0.378302559933253 no 1271 0.393473732007186 1902 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.269111733391413 0.378750640456874 no 1272 0.393921850731153 1911 5282309
SGTC_894 0960-0238 55.9 µM 0.269090659297681 0.37875874835453 no 1273 0.393929959112337 1944 6741907 YDL195W SEC31
SGTC_332 4112-0506 40.9 µM 0.268412325835494 0.379019754051247 no 1274 0.394190976432473 1838 2790355
SGTC_2165 5727197 32.143 µM 0.267976733036998 0.379187388327699 no 1275 0.394358614142884 1865 1361712
SGTC_3101 9120531 49.47 µM 0.267853584396387 0.379234785181973 no 1276 0.394406011396484 1935 24824904
SGTC_1738 st035555 74 µM 0.26767113074003 0.37930501040146 no 1277 0.394476236744482 1857 5331140
SGTC_2269 7935389 174.42 µM 0.26569748792382 0.380064906719597 no 1278 0.395236099107103 1765 97605
SGTC_898 1000-0849 28.3 µM 0.26433127867406 0.380591199134942 no 1279 0.395762330115355 1961 6751807
SGTC_2890 9046729 58.44 µM 0.264195876395667 0.380643370984574 no 1280 0.395814494190082 1772 903329
SGTC_1094 duloxetine 25.4 µM 0.263955165925148 0.380736124490931 no 1281 0.395907233122584 1849 60834 A selective serotonin reuptake inhibitor.
SGTC_2620 irigenin 100 µM 0.263629636600322 0.380861572340107 no 1282 0.396032659731302 1917 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1762 st045503 25.4615 µM 0.263206484091329 0.381024659540588 no 1283 0.396195716689737 1805 4645554
SGTC_1759 st043059 70 µM 0.262688959289698 0.381224147495122 no 1284 0.396395163613391 1764 669426
SGTC_3150 9097574 49.47 µM 0.260968180069041 0.381887675207959 no 1285 0.397058522900386 1959 17217476
SGTC_2375 9072683 200 µM 0.260648670833209 0.382010915355357 no 1286 0.39718172635926 1997 16798029
SGTC_618 k072-0232 33.2 µM 0.260163395849286 0.382198117039144 no 1287 0.397368869075453 1854 5872756 YGL099W LSG1
SGTC_3109 9122853 49.47 µM 0.259895030192395 0.382301654713793 no 1288 0.397472372459694 1907 1234709
SGTC_2324 6149169 200 µM 0.259114675626023 0.382602769705717 no 1289 0.397773380942809 1931 2888231
SGTC_1647 st011722 22.4 µM 0.258856515598424 0.382702401410585 no 1290 0.397872975184591 1896 2854783
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.258444283570345 0.382861510218662 no 1291 0.398032021875298 1876 6708739 YPR165W RHO1
SGTC_5 0352-0601 109.883 µM 0.257763081895177 0.383124476302077 no 1292 0.398294879123196 1873 762456
SGTC_3355 9151058 44.0485 µM 0.257291326739624 0.383306620769869 no 1293 0.398476943699757 1932 17015728
SGTC_3187 9109394 49.47 µM 0.257228687689704 0.383330807621741 no 1294 0.398501119665662 1794 17098090
SGTC_160 3453-0671 289.699 µM 0.256687814032375 0.383539674380144 no 1295 0.398709889714238 1837 5322268
SGTC_2753 fluvastatin 17.09 µM 0.25540317581456 0.384035892930975 no 1296 0.399205859083818 1871 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2918 7977171 22.06 µM 0.254656455404369 0.384324416855535 no 1297 0.399494225564389 1838 2236483
SGTC_2539 epi(13)torulosol 80 µM 0.253459376140536 0.384787087804695 no 1298 0.399956624779884 1797 6708597
SGTC_52 0329-0193 875 nM 0.253155636346704 0.384904509318418 no 1299 0.400073973558052 1939 3739292
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.247423622181683 0.387122393096258 no 1300 0.402290197266996 1932 688801
SGTC_47 0149-0135 24.25 µM 0.246997086538513 0.387287580603896 no 1301 0.402455239420127 1747 5239155
SGTC_696 1560-0013 611 µM 0.246748273240262 0.387383949736567 no 1302 0.40255152236638 1928 1650269
SGTC_423 5-fluorouracil 457 µM 0.246497835110497 0.387480955199068 no 1303 0.402648440040911 1734 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1357 1503-1303 39.5 µM 0.246450442907241 0.387499313029072 no 1304 0.402666781140907 1855 292895
SGTC_2974 9094440 9.66 µM 0.244143425929842 0.388393261862771 no 1305 0.403559870446898 1930 25236134
SGTC_1806 st050005 60.3 µM 0.24360262178987 0.388602904480875 no 1306 0.403769298782936 1824 5194765
SGTC_2862 9027634 71.43 µM 0.242469896416467 0.389042110346951 no 1307 0.404208040083866 1777 5012562
SGTC_2778 tioconazole 65.09 nM 0.24171682030659 0.389334188552083 no 1308 0.404499797632858 1855 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1100 amiodarone 5.07 µM 0.240978277476698 0.389620690807832 no 1309 0.404785976270163 2030 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_270 tamoxifen 5.46 µM 0.240793818214915 0.389692257292979 no 1310 0.404857460513834 1993 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_25 0118-0223 35.662 µM 0.240184172716659 0.389928814087037 no 1311 0.40509374147529 1962 5333628
SGTC_2908 7930301 100 µM 0.240120299255237 0.389953600853796 no 1312 0.40511849898534 1879 2223178
SGTC_2914 7968218 45.32 µM 0.239237497066012 0.390296227295225 no 1313 0.40546071412524 1974 2977111
SGTC_2600 tangeritin 87.95 µM 0.238788915592251 0.390470359982514 no 1314 0.405634632856054 1830 68077 A bioactive flavone.
SGTC_3004 9076122 71.4286 µM 0.237963845356662 0.390790697383813 no 1315 0.405954568002347 1968 44782551
SGTC_141 0443-0274 32.331 µM 0.236923342120104 0.391194783324369 no 1316 0.406358130534691 2021 1627241
SGTC_2148 5546263 113.568 µM 0.23560738357707 0.39170601225173 no 1317 0.40686867173848 1882 792097
SGTC_3237 9133362 49.47 µM 0.235344070529377 0.391808327663732 no 1318 0.406970846089195 1969 43845137
SGTC_2876 9059903 25.97 µM 0.234657408016083 0.392075178939874 no 1319 0.407237324091966 1968 6916095
SGTC_2556 citropten 84.59 µM 0.233670983323209 0.39245861283342 no 1320 0.407620208056293 1798 2775 A potential DNA crosslinker.
SGTC_1399 3562-5772 25 µM 0.23225420832348 0.39300951112733 no 1321 0.408170288232704 1901 23847490
SGTC_2816 7982706 58.44 µM 0.231731299585152 0.393212892992973 no 1322 0.408373359723694 1867 2981853
SGTC_1778 st046819 58.9 µM 0.231572339548248 0.393274725218658 no 1323 0.40843509669816 1858 671715
SGTC_2089 5281248 129.67 µM 0.231046147126765 0.393479422580427 no 1324 0.408639475764722 1848 2737878
SGTC_1451 4152-0210 104 µM 0.230543004432896 0.393675180765305 no 1325 0.40883492529798 2003 659563
SGTC_509 pifithrin 175 µM 0.229797223978636 0.393965391671513 no 1326 0.409124670975389 1935 4817 A p53 inhibitor.
SGTC_756 0508-1999 28.3 µM 0.228732416965515 0.394379849708771 no 1327 0.409538448767818 1796 6753853
SGTC_752 1896-0090 130 µM 0.225858201609099 0.395499185119078 no 1328 0.41065585404308 1890 772567
SGTC_1273 0849-0096 14.1 µM 0.225857817315718 0.395499334836301 no 1329 0.410656003493069 1873 5286025
SGTC_2869 9037858 32.47 µM 0.225329935122484 0.395705007513066 no 1330 0.410861306772392 2018 27187042
SGTC_2020 4017018 200 µM 0.225112769135088 0.395789627838464 no 1331 0.410945773788498 1890 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2536 dehydroabietamide 32.04 µM 0.223991907961366 0.396226457663236 no 1332 0.411381799893169 2007 3983547
SGTC_2050 5263056 171 µM 0.222185668512929 0.396930671894359 no 1333 0.412084675088175 2036 763468 YGL055W OLE1
SGTC_964 1287-0107 19.4 µM 0.221887529908242 0.39704694216728 no 1334 0.41220071913492 2000 51516812 YPR165W RHO1
SGTC_2729 fluphenazine 10.66 µM 0.221864375858425 0.397055972336006 no 1335 0.412209731672757 1925 3372 An atypical antipsychotic.
SGTC_3323 9138564 53.9225 µM 0.220001175988247 0.397782807983726 no 1336 0.412935119417601 2032 43912313 YNL103W MET4
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.21981452122526 0.397855641746765 no 1337 0.413007804957065 1895 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1617 st002906 78 µM 0.219559978220521 0.397954971629976 no 1338 0.413106931774985 1889 5150859
SGTC_1638 st008370 60.6 µM 0.21938440048213 0.398023490887078 no 1339 0.413175310336219 1967 24207134
SGTC_3072 9116419 49.47 µM 0.218339640701355 0.398431273627559 no 1340 0.413582245306534 1902 17170162
SGTC_3268 9137683 49.47 µM 0.214996878867284 0.39973673837938 no 1341 0.414884875983469 1896 1953228
SGTC_2797 7859098 81.82 µM 0.214471671175955 0.399941952573008 no 1342 0.41508962805464 1904 972681
SGTC_2309 7664088 163.95 µM 0.21439808137635 0.399970708495036 no 1343 0.415118318860907 2077 704922
SGTC_2658 polymyxin b sulfate 77.05 µM 0.212002557750929 0.400907077760965 no 1344 0.416052519441093 1942 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1148 3909-7663 27.7 µM 0.211257513714546 0.40119841912423 no 1345 0.416343166924196 2040 4084526
SGTC_1694 st024011 44.9 µM 0.210585989935208 0.401461058276529 no 1346 0.416605172787818 2024 2787533
SGTC_3145 9085516 49.47 µM 0.209004239254657 0.402079871325712 no 1347 0.417222464627759 1835 25236195
SGTC_3192 9110362 49.47 µM 0.206956880218847 0.402881204219267 no 1348 0.418021766997551 1975 16649480
SGTC_1718 roemerine 11.9335 µM 0.204774912316612 0.403735672003346 no 1349 0.418873994360576 2023 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2025 5147754 141 µM 0.204129571009228 0.403988478623911 no 1350 0.419126123250872 2034 315777 YLR208W SEC13
SGTC_3271 9137798 49.47 µM 0.203330575901834 0.404301533289419 no 1351 0.419438329271438 2042 6498326
SGTC_1814 st052110 31.539 µM 0.201879288545008 0.404870319534321 no 1352 0.420005547026186 2031 674163
SGTC_2326 6164455 177.58 µM 0.201549215354284 0.404999709401904 no 1353 0.420134575300705 1917 2888790
SGTC_1696 st025591 34.7925 µM 0.200868489178648 0.405266589272562 no 1354 0.420400703749083 1954 2787147
SGTC_1242 0402-0103 60.1 µM 0.200479883627458 0.405418962510585 no 1355 0.420552644586591 1962 432868
SGTC_97 0535-0701 19.132 µM 0.199783642075818 0.405691996452796 no 1356 0.420824897576299 1908 2832013 YGL099W LSG1
SGTC_570 0987-0065 62.6 µM 0.198937803091527 0.406023757359341 no 1357 0.421155698946396 2068 3104428
SGTC_1864 st057645 30.4 µM 0.198314859125673 0.406268135990448 no 1358 0.421399363333028 2088 688666
SGTC_2725 haloperidol 53.21 µM 0.196714230918646 0.406896223812242 no 1359 0.422025586514211 2050 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2338 7999974 200 µM 0.195440991523822 0.407396015138546 no 1360 0.422523864349452 2084 315925
SGTC_2665 lovastatin 100 µM 0.194593304911226 0.407728845669791 no 1361 0.42285567238676 1959 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3039 9090270 49.47 µM 0.19447804910731 0.40777410415885 no 1362 0.422900790935463 2091 17173750
SGTC_1482 3346-2049 8.48 µM 0.1930497098488 0.408335084392201 no 1363 0.423460018708394 2043 3826804
SGTC_489 paxilline 115 µM 0.192610567940458 0.408507595194213 no 1364 0.42363198394477 1953 105008 A toxic potassium channel blocker.
SGTC_2630 antimycin a 100 µM 0.192374688147682 0.408600264617883 no 1365 0.423724359009616 1967 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2491 paeonol 100 µM 0.191773136145393 0.408836617767356 no 1366 0.423959957311572 1935 11092 Increases levels of cortical cytochrome oxidase.
SGTC_973 1325-0077 65.9 µM 0.191316177761725 0.409016181438191 no 1367 0.424138943582321 2038 2835149
SGTC_3183 9108214 49.47 µM 0.190881604515436 0.409186966493666 no 1368 0.424309176324549 2054 4974831
SGTC_3046 9092212 49.47 µM 0.189929246453878 0.409561298567966 no 1369 0.424682287113369 2024 25236637
SGTC_2771 fluoxetine 41.05 µM 0.18914087216047 0.409871237892595 no 1370 0.424991204116085 2045 3386 A selective serotonin reuptake inhibitor.
SGTC_1413 3910-0535 34.4 µM 0.188960031882897 0.409942340895813 no 1371 0.425062071168896 2068 2876951
SGTC_2116 5511452 16.8835 µM 0.18781731359559 0.410391704666358 no 1372 0.425509931504949 2006 870744
SGTC_2251 lansoprazole 556 µM 0.187772868645389 0.410409184627582 no 1373 0.425527352556215 1880 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_251 melphalan 456.522 µM 0.187026893377626 0.410702599247574 no 1374 0.425819773552858 2019 460612 A DNA alkylator.
SGTC_70 0141-0289 43.283 µM 0.18626634340046 0.411001797994658 no 1375 0.426117949813164 1979 352408
SGTC_1849 st056239 19.2 µM 0.186213107605442 0.411022742784612 no 1376 0.426138822675403 1867 5393181
SGTC_1990 st072050 59.8 µM 0.185994333894334 0.411108818538065 no 1377 0.426224602349555 1908 17233948
SGTC_197 4544-0043 41.561 µM 0.185507887228219 0.411300224613984 no 1378 0.426415347259931 2086 896523
SGTC_852 0418-0143 439 µM 0.18355673028816 0.412068173765224 no 1379 0.427180605239598 2082 5369229
SGTC_66 0109-0187 42.4 µM 0.178973874877582 0.413873243896138 no 1380 0.428979107644699 1946 759417
SGTC_333 3486-0131 40.1 µM 0.177007959493601 0.414648128394788 no 1381 0.429751068765931 2096 6744690
SGTC_3073 9114972 49.47 µM 0.174920624824494 0.415471235104317 no 1382 0.430571001928587 2121 41905075
SGTC_202 3594-0513 34.79 µM 0.173301725314763 0.416109877671716 no 1383 0.43120713380371 2097 708429
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.172660956655218 0.416362716948447 no 1384 0.431458967431997 1881 641818 YHR062C RPP1
SGTC_386 1509-0011 3.07 µM 0.172161363291015 0.416559874243196 no 1385 0.431655335961946 1997 3107280
SGTC_757 1066-0008 322 µM 0.171977909708036 0.416632276818361 no 1386 0.431727447868293 2072 6842497
SGTC_3060 1327-0027 12.5 µM 0.171290911429434 0.416903435603062 no 1387 0.431997513240454 2112 16000455 YPR107C YTH1
SGTC_844 0330-0132 15.3 µM 0.170199510698424 0.417334293615887 no 1388 0.432426618255635 2095 2828079
SGTC_3270 9137563 49.47 µM 0.170099758381028 0.417373678322882 no 1389 0.432465841765359 2071 17015724
SGTC_2493 resveratrol 26.09 µM 0.169321224802153 0.417681091283218 no 1390 0.432771991018965 2001 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_834 0312-0008 75.7 µM 0.16667398404477 0.418726760135662 no 1391 0.433813288443688 2061 6385573 YIL048W NEO1
SGTC_940 3232-1287 54.8 µM 0.166594453389408 0.418758183933362 no 1392 0.43384457913135 2141 1585493 YIL048W NEO1
SGTC_1258 0671-0043 57.1 µM 0.166405035817048 0.418833027846628 no 1393 0.433919105599421 1970 4298767
SGTC_1435 4092-0789 56.7 µM 0.165452909291453 0.419209282768375 no 1394 0.434293755933715 2119 2248285
SGTC_1973 st070275 50.2 µM 0.165187038786944 0.419314360889115 no 1395 0.434398383335232 2132 17118334
SGTC_2984 9022109 38.96 µM 0.163314212417165 0.420054707447373 no 1396 0.435135522121623 2160 6459207
SGTC_3114 9122766 49.47 µM 0.163020361301736 0.420170895413928 no 1397 0.435251201560819 1975 17176985
SGTC_2979 9012552 45.46 µM 0.162436173409693 0.420401902440943 no 1398 0.435481193410583 2161 17100905
SGTC_3291 9121177 71.43 µM 0.162255797302434 0.42047323460548 no 1399 0.435552210994823 1985 17015612
SGTC_682 0kpi-0099 17 µM 0.16144373967881 0.420794406059773 no 1400 0.435871959597038 1982 1714895 YML126C ERG13
SGTC_1920 st075728 45.7 µM 0.15913233635896 0.421708861588111 no 1401 0.436782306045064 2150 3400306
SGTC_902 1120-0002 2.07 µM 0.158525081066962 0.421949178951841 no 1402 0.437021529352155 2098 3280475
SGTC_2456 5770359 74.46 µM 0.158137792793157 0.422102460973315 no 1403 0.437174110465896 2107 3118787
SGTC_3155 9099265 49.47 µM 0.157340982811326 0.422417861715104 no 1404 0.4374880614328 2062 25236499
SGTC_768 0384-0033 77.3 µM 0.155414613184342 0.423180580421341 no 1405 0.438247232241418 1945 3965305 YMR134W ERG29
SGTC_182 3448-4371 550.524 µM 0.154630671093661 0.423491053772729 no 1406 0.43855624438808 2191 3491403
SGTC_478 N-arachidonylglycine 10 µM 0.153928947837023 0.423769005382386 no 1407 0.438832879519263 2135 5283389
SGTC_2900 5328528 85.29 µM 0.150837417434632 0.424994006144888 no 1408 0.440051984545869 2087 795359
SGTC_1581 himbacine 57.9 µM 0.150712760980781 0.425043415809735 no 1409 0.440101153208729 1991 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1866 st057638 64 µM 0.150490554534013 0.425131493961212 no 1410 0.440188801132666 2032 688802
SGTC_690 glyoxal 20.3 µM 0.150271276394937 0.42521841505428 no 1411 0.440275296877531 2070 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1744 st037937 38.9 µM 0.149452840907772 0.425542872111869 no 1412 0.440598159429364 2082 1016152
SGTC_2436 5633522 8.09 µM 0.149250000328246 0.425623293168053 no 1413 0.440678183613419 2155 5724242
SGTC_1274 0865-0114 173 µM 0.14832573898962 0.425989778063667 no 1414 0.441042851625074 2057 870624
SGTC_2323 6148992 148.28 µM 0.14762087930526 0.426269309564385 no 1415 0.441320988166734 2027 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1495 4469-0029 237 µM 0.146170945982979 0.426844436846742 no 1416 0.44189322046583 2108 793680
SGTC_2957 9076800 11.52 µM 0.14574662494695 0.427012776550052 no 1417 0.442060706472432 2024 16459615
SGTC_1263 0774-1208 64.8 µM 0.145547111423307 0.427091933591312 no 1418 0.442139461095514 2164 906585
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.145414850564217 0.427144409739165 no 1419 0.442191670115982 2069 5393153
SGTC_2483 5729050 27.16 µM 0.145216317359208 0.427223182687862 no 1420 0.442270041551767 2144 2865180
SGTC_916 4466-0038 42 nM 0.143749827680118 0.427805138341527 no 1421 0.442849011486798 2183 5722064 YGL116W CDC20
SGTC_3178 9107506 49.47 µM 0.143371391504683 0.427955340926693 no 1422 0.442998437902693 2101 8897194
SGTC_919 tnp00227 403.569 nM 0.142726366244274 0.4282113776633 no 1423 0.4432531463223 2044 1269246 A methoxyflavone. YNL221C POP1
SGTC_2331 7980721 200 µM 0.141975317206427 0.428509537623501 no 1424 0.443549751091476 2119 2981221
SGTC_1933 st074711 15.9 µM 0.141819224440208 0.428571510227036 no 1425 0.443611399322407 2163 17250958
SGTC_992 3909-8734 162 µM 0.141696743396052 0.428620139397293 no 1426 0.443659773690066 2030 4288319
SGTC_602 3130-1533 38.1 µM 0.141683664810831 0.4286253321077 no 1427 0.443664939178098 2147 720941
SGTC_361 000s-0510 1.45 µM 0.141537335677581 0.428683431345199 no 1428 0.443722733649514 2063 660
SGTC_665 3914-0008 307 µM 0.140431116357253 0.429122700013301 no 1429 0.444159687071569 2068 1069549
SGTC_1018 4259-0013 28.1 µM 0.140154096489135 0.429232715608653 no 1430 0.444269119764696 2049 6801262
SGTC_3276 9139060 49.47 µM 0.139516587077622 0.429485916792051 no 1431 0.44452097476565 2195 4870619
SGTC_119 0121-0043 24.815 µM 0.138654500463585 0.429828359978996 no 1432 0.444861587034246 2171 1092378
SGTC_2645 abamectin 100 µM 0.138508208311385 0.429886476267382 no 1433 0.444919391424849 2129 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_547 1120-0019 610 nM 0.136549590319887 0.430664706277734 no 1434 0.445693412117595 2063 3676939
SGTC_947 3447-0010 211 µM 0.136332806204028 0.430750859084969 no 1435 0.445779095196903 2153 748350
SGTC_1930 st074634 34.3 µM 0.135558665307498 0.431058539545408 no 1436 0.4460850920184 2137 684253 YOR116C RPO31
SGTC_2142 5622915 118.518 µM 0.135338426335243 0.431146080655586 no 1437 0.44617215236392 2050 5322196
SGTC_3097 9117246 49.47 µM 0.134810000675426 0.431356134329449 no 1438 0.446381049313596 2181 16423892
SGTC_2466 5983409 37.09 µM 0.131013522163065 0.432865833966852 no 1439 0.447882305234655 2054 2879657
SGTC_2114 5491910 81.25 µM 0.130841668946689 0.432934196114388 no 1440 0.447950279634897 2143 2849228
SGTC_1157 4092-0394 27.6 µM 0.129737917968903 0.433373309189975 no 1441 0.44838689094099 2151 3659885
SGTC_595 3909-8003 73.7 µM 0.128153473771021 0.43400380352725 no 1442 0.449013759465399 2126 699517
SGTC_1818 st052136 56.3 µM 0.125431922903571 0.435087175290465 no 1443 0.450090808427435 2102 674169
SGTC_2102 5377816 72.7585 µM 0.124771453212091 0.4353501632497 no 1444 0.450352243893249 2180 1379702
SGTC_2408 sulbentine 18.36 µM 0.124623197682818 0.435409200050361 no 1445 0.450410931236646 2065 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3262 9137218 49.47 µM 0.12352408918389 0.435846920609606 no 1446 0.450846049975797 2206 17650664
SGTC_60 0986-0278 202 µM 0.122064147202223 0.436428464751665 no 1447 0.451424107945313 1913 3110598
SGTC_1085 doxorubicin 7.67 µM 0.121540175968609 0.436637213750373 no 1448 0.451631597366755 2198 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1442 4112-3290 3 µM 0.12113849468838 0.436797254650331 no 1449 0.45179066966136 2196 704353
SGTC_2938 9059746 27.26 µM 0.118681502718619 0.437776412223652 no 1450 0.452763845826309 2141 6471769
SGTC_520 3584-0023 682 µM 0.117091453318127 0.438410280376343 no 1451 0.453393791205726 2015 1340790
SGTC_1443 4112-3303 14 µM 0.116861354221257 0.438502021778985 no 1452 0.453484961561435 2159 704433
SGTC_2629 bisabolol 100 µM 0.116402221541584 0.43868508963046 no 1453 0.453666887414244 2128 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2159 5658611 73.75 µM 0.115595062910544 0.439006956041246 no 1454 0.453986737951399 2209 793844
SGTC_2995 9067767 71.4286 µM 0.115379114096616 0.439093075664253 no 1455 0.454072316464642 2111 11673567
SGTC_1792 st045773 43.6 µM 0.115322108447442 0.439115809796627 no 1456 0.454094907630896 2077 2919270
SGTC_2569 tetrandrine 100 µM 0.114103128765038 0.439601992813733 no 1457 0.454578021014698 2016 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2643 anethole 100 µM 0.113051701975176 0.440021421538419 no 1458 0.454994782831102 2134 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1489 4065-0444 182 µM 0.112791111502823 0.440125385119258 no 1459 0.455098082683323 2219 2877968
SGTC_565 1418-0001 44.5 µM 0.11222287181829 0.440352100854266 no 1460 0.455323347314904 2198 2862145
SGTC_3026 9090633 49.47 µM 0.111780386022544 0.440528656968308 no 1461 0.455498769865827 2146 25236842
SGTC_1416 3966-0321 25.3 µM 0.111125069605449 0.44079015627189 no 1462 0.455758584593824 2135 582530 YLR208W SEC13
SGTC_2362 9071156 126 µM 0.111056456813412 0.440817537208376 no 1463 0.455785788753149 2184 653133
SGTC_1387 3342-1166 1.8 µM 0.110951394132188 0.44085946455363 no 1464 0.455827445263472 2132 3418228
SGTC_2064 5220758 200 µM 0.110774668601173 0.440929991874635 no 1465 0.45589751661402 2115 788518
SGTC_606 k015-0008 38.6 µM 0.10987859725239 0.441287623274981 no 1466 0.456252828334812 2194 1970475
SGTC_1504 k297-0033 30 µM 0.107760434635016 0.442133193858302 no 1467 0.457092864328458 2086 4388117
SGTC_814 3342-0569 96 µM 0.10760290612522 0.442196089827807 no 1468 0.457155345812102 2218 4346283
SGTC_3221 9128209 49.47 µM 0.106341989556079 0.442699584856594 no 1469 0.457655508799614 2121 16460723
SGTC_91 0417-1751 58.384 µM 0.103814375479129 0.443709161224452 no 1470 0.458658329065612 2229 6795624
SGTC_2611 pyromycin 23.93 µM 0.102821277971983 0.444105923319081 no 1471 0.45905240869472 2130 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1779 st039427 55 µM 0.101975452482032 0.444443891524636 no 1472 0.459388079786282 2248 1124498
SGTC_69 0096-0274 206.684 µM 0.101488080330316 0.444638650164249 no 1473 0.459581509611052 2168 6741392
SGTC_1237 0330-0133 46.1 µM 0.100610515521297 0.444989367245915 no 1474 0.459929824444212 2176 X1237 YHR072W ERG7
SGTC_2885 9057732 51.95 µM 0.0999724500591221 0.445244395931212 no 1475 0.460183098757248 2158 6471414
SGTC_2232 chlorophetanol 41.5365 µM 0.0976909450050672 0.446156476421877 no 1476 0.46108885300127 2234 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_6 0844-0013 19.835 µM 0.0972782308259535 0.446321498328904 no 1477 0.461252721641136 2234 1584900
SGTC_528 3492-0019 172 µM 0.0970737262718147 0.4464032720011 no 1478 0.461333922849187 2233 2869262
SGTC_1851 st056236 18.9 µM 0.0960328578306716 0.446819511356659 no 1479 0.461747238188976 2245 5393171
SGTC_580 1123-0028 41 µM 0.0958568954835441 0.446889883836658 no 1480 0.461817114646565 2225 1677248 YPR107C YTH1
SGTC_3300 9124615 50.48 µM 0.0949611351304316 0.447248150434294 no 1481 0.462172848521051 2207 24824903
SGTC_2146 5545642 200 µM 0.094490000296777 0.447436601915474 no 1482 0.462359962756504 2219 825326
SGTC_3213 9129884 49.47 µM 0.0937986175804123 0.447713172876771 no 1483 0.46263456492789 2134 17190742
SGTC_1028 k015-0029 4.8 µM 0.0931192176642569 0.44798497517477 no 1484 0.462904425140918 2244 4588309
SGTC_273 hydroxyurea 18.1 mM 0.0919266526766347 0.448462134459504 no 1485 0.463378157670816 2255 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1256 0570-0116 285 µM 0.0910832970909003 0.448799616006352 no 1486 0.463713202230227 2162 410638
SGTC_143 4032-1194 15.74 µM 0.0897848054036851 0.449319299530805 no 1487 0.464229111474876 2200 1806963
SGTC_1457 k015-0032 57.3 µM 0.0888925976666361 0.449676430174034 no 1488 0.464583633234987 2263 4302660
SGTC_1825 st052143 62.6 µM 0.0887207565009846 0.449745219009301 no 1489 0.464651918141037 2241 674173
SGTC_1742 st038235 28.8875 µM 0.0863516657944433 0.450693730314893 no 1490 0.465593434226594 2168 564103 YBR002C RER2
SGTC_3126 9127922 49.47 µM 0.0823031778172017 0.452315269824216 no 1491 0.467202813731688 2190 45595682
SGTC_1976 st070609 63.5 µM 0.081088134600927 0.452802087141375 no 1492 0.467685930914944 2253 682556
SGTC_801 0866-0028 10.1 µM 0.0800851567228408 0.45320399218109 no 1493 0.468084764022822 2259 6849771
SGTC_40 0327-0103 19.753 µM 0.0797720958105215 0.453329449209078 no 1494 0.468209258947539 2210 409036
SGTC_42 0133-0086 60.653 µM 0.0784223211606506 0.453870415385646 no 1495 0.46874605924438 2257 162923 Model of phenazepam hydroxylation.
SGTC_138 0850-0259 40.9225 µM 0.0773822333360304 0.454287322918077 no 1496 0.469159737071253 2288 6813004
SGTC_1463 k081-0032 34.1 µM 0.0766300786215455 0.454588847104119 no 1497 0.469458915010066 2221 977755
SGTC_1945 st075991 56.6 µM 0.075648590452446 0.454982345936581 no 1498 0.469849338799021 2099 1084980
SGTC_649 1123-0311 367 µM 0.0746780022900032 0.455371518177344 no 1499 0.470235455210437 2263 693629 YIL048W NEO1
SGTC_1150 3909-7983 10.9 µM 0.0721910058915815 0.456368912208657 no 1500 0.471224951378975 2148 23965914
SGTC_1029 k015-0030 64.7 µM 0.072022587135794 0.456436465487145 no 1501 0.471291966296389 2193 2208316
SGTC_2395 5646831 180.19 µM 0.0717926424287074 0.456528699045767 no 1502 0.471383464101865 2237 6808628
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0708712667850195 0.456898297227474 no 1503 0.471750105819817 2275 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_250 brefeldin a 552.239 µM 0.069338019546079 0.457513422456104 no 1504 0.472360281662637 2270 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1651 st011928 86.1 µM 0.0691277537045313 0.457597787221625 no 1505 0.472443964801584 2242 720198
SGTC_148 3253-0744 288.01 µM 0.0682768555900913 0.457939211742179 no 1506 0.472782623845241 2313 6893655
SGTC_868 0527-0199 213 µM 0.068196346454763 0.457971517800326 no 1507 0.472814667654632 2157 2849450
SGTC_3304 9125678 46.087 µM 0.0674136896743574 0.458285590454672 no 1508 0.473126185598675 2251 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_824 1304-0008 100 µM 0.0658525906264774 0.458912122114335 no 1509 0.473747592900864 2237 768245
SGTC_3050 9093513 49.47 µM 0.0652271834136764 0.459163151837769 no 1510 0.473996558987822 2275 25236664
SGTC_675 1309-0189 238 µM 0.0622990511098436 0.46033867823565 no 1511 0.475162342057757 2226 4246530
SGTC_3307 9126885 69.2785 µM 0.0619625848350905 0.460473778206929 no 1512 0.475296313848811 2273 24824909
SGTC_1395 3486-0190 4.35 µM 0.061862801977348 0.460513844500711 no 1513 0.475336045227792 2301 6748079
SGTC_1789 tunicamycin 25 nM 0.0617388648419481 0.460563610136663 no 1514 0.475385394659937 2270 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2476 5806916 10.51 µM 0.0615696565361364 0.460631554925856 no 1515 0.475452770828711 2254 2870194
SGTC_2263 7948595 193.29 µM 0.0615606003406894 0.460635191430422 no 1516 0.475456376887535 2302 2971371
SGTC_831 k061-1017 217 µM 0.0615064128949567 0.460656950403912 no 1517 0.475477953663156 2264 1240153
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0591454316509317 0.461605116117052 no 1518 0.476418136364871 2304 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_73 0327-0325 16.231 µM 0.0587935698642374 0.461746441981065 no 1519 0.476558265053894 2320 53298
SGTC_2128 5255449 168.493 µM 0.058350130969142 0.461924556818467 no 1520 0.476734868383378 2289 736008
SGTC_1800 st050079 29.0735 µM 0.0580080050590164 0.462061982778399 no 1521 0.47687112607545 2281 3645560
SGTC_3231 9132313 49.47 µM 0.0570600451706306 0.4624427852015 no 1522 0.477248681937614 2219 4905967
SGTC_2440 5628896 157.78 µM 0.0569900781910143 0.462470892817606 no 1523 0.477276549376681 2279 5522048
SGTC_1200 1643-0193 18.4 µM 0.0560770877399968 0.462837682744674 no 1524 0.477640198272716 2301 5403974
SGTC_3212 9128307 49.47 µM 0.0556708287906795 0.463000905680832 no 1525 0.477802019351484 2089 27243542
SGTC_2434 5670830 169.91 µM 0.0544868553070304 0.463476626949865 no 1526 0.47827364048912 2249 1549830
SGTC_1827 berberine 7.24 µM 0.053961847313548 0.463687592238309 no 1527 0.47848278068136 2290 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_821 1114-0266 29.2 µM 0.0537289167929047 0.463781194571671 no 1528 0.478575571900724 2255 3123235
SGTC_350 k064-0020 19.8 µM 0.0531736650905757 0.464004328646137 no 1529 0.478796769067775 2318 2790705
SGTC_3208 9114115 49.47 µM 0.0515905185712804 0.464640595618078 no 1530 0.47942748718224 2187 650895
SGTC_679 0422-0091 41.4 µM 0.0507651724453304 0.464972338390046 no 1531 0.47975632171934 2315 627384 YHR062C RPP1
SGTC_1379 2144-0755 36.5 µM 0.0507500385484361 0.464978421594347 no 1532 0.479762351498309 2305 5392327
SGTC_1596 piperlongumine 63 µM 0.0505378509241666 0.465063713156158 no 1533 0.479846893626092 2317 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1223 0764-0573 147 µM 0.0500375901662453 0.465264805788493 no 1534 0.480046216602736 2316 1609797
SGTC_997 3996-0078 137 µM 0.0499718064295477 0.46529124990841 no 1535 0.480072427726107 2278 735687
SGTC_2322 7413319 38.22 µM 0.0492746352563161 0.465571512131392 no 1536 0.480350216545037 2268 1840400
SGTC_892 0929-0076 29 µM 0.047364703760061 0.466339390043921 no 1537 0.481111279875525 2321 5751038
SGTC_1369 1866-0067 208 µM 0.0473215452544697 0.466356743152732 no 1538 0.481128478343282 2297 3531355
SGTC_1271 0832-2808 169 µM 0.0468594437471167 0.466542548252902 no 1539 0.481312625882598 2325 3663794
SGTC_1257 0669-0121 16 µM 0.0434594684010797 0.467909856386601 no 1540 0.482667636755135 2288 4307855
SGTC_3108 9121785 49.47 µM 0.0432428499968916 0.467996982992583 no 1541 0.482753973829357 2342 17140271
SGTC_3064 1327-0027 10 µM 0.0432373881781175 0.467999179823595 no 1542 0.482756150743745 2280 16000455 YPR107C YTH1
SGTC_2265 7929201 200 µM 0.0428329405088239 0.46816185785914 no 1543 0.48291735267397 2329 1265108
SGTC_441 propafenone 146 µM 0.0421058518021008 0.468454322797921 no 1544 0.483207157623132 2330 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1453 4237-0541 195 µM 0.0410378898190542 0.468883931793114 no 1545 0.483632844792211 2334 739892
SGTC_2646 retinol 96.75 µM 0.0407514726281164 0.468999154999787 no 1546 0.483747013212991 2308 445354 A vitamin A analog and teratogen.
SGTC_1169 aniline yellow 25.8 µM 0.0403672529743764 0.469153727383889 no 1547 0.483900168649977 2307 6051 A DNA damaging agent.
SGTC_2768 sulfasalazine 50.2 µM 0.0400180603714158 0.469294212344459 no 1548 0.484039363865744 2331 5384001 An antioxidant and salicylic acid derivative.
SGTC_1501 4491-0275 38.4 µM 0.0384847824148537 0.469911116051985 no 1549 0.484650582184886 2345 5104718
SGTC_1526 st051518 75 µM 0.0370039427006146 0.470506990181339 no 1550 0.485240931037304 2198 673993
SGTC_497 capsazepine 133 µM 0.0365414861035829 0.470693091386402 no 1551 0.485425299828181 2327 2733484 A calcium channel blocker.
SGTC_2365 9042475 200 µM 0.0364615613907693 0.470725255239145 no 1552 0.485457163941036 2301 6464479
SGTC_1002 4049-0206 172 µM 0.0349852359937931 0.471319402385604 no 1553 0.486045756818554 2327 4662749
SGTC_2228 7354201 200 µM 0.0343139482987369 0.471589583307456 no 1554 0.486313401143053 2291 753451
SGTC_2377 9073351 62.6 µM 0.034251301952458 0.471614797975897 no 1555 0.486338378736916 2328 7337946 YHR072W ERG7
SGTC_2351 9026858 72.31 µM 0.0337864099697935 0.471801916941045 no 1556 0.486523736516252 2343 1409300
SGTC_1164 k060-0068 93.7 µM 0.0330883230367089 0.472082908522614 no 1557 0.486802077259631 2351 5963676
SGTC_1872 amphotericin b 148 nM 0.0328242782590554 0.472189194559277 no 1558 0.486907358695505 2333 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_620 0109-0052 432 µM 0.0323564392206533 0.472377518829342 no 1559 0.487093900374441 2352 493037
SGTC_2966 9084041 48.03 µM 0.0320570987574977 0.472498018801494 no 1560 0.487213258021518 2349 17741380
SGTC_2254 7938975 95.19 µM 0.0315858113116492 0.472687741397725 no 1561 0.487401179339028 2344 2969277
SGTC_3247 9135149 49.47 µM 0.0310260045386455 0.472913106593175 no 1562 0.487624400514858 2352 8934436 YOR116C RPO31
SGTC_2275 7947463 200 µM 0.0305265903766825 0.473114166447535 no 1563 0.487823543602868 2353 1225414
SGTC_2241 6772625 37.8075 µM 0.0302196520419077 0.473237740588122 no 1564 0.487945937812632 2359 2285411
SGTC_413 propylparaben 100 µM 0.0284252725911753 0.473960213395761 no 1565 0.488661483864846 2335 7175 A pharmaceutical preservative.
SGTC_2635 hydroquinidine 100 µM 0.0274686870797823 0.474345399537892 no 1566 0.489042957254747 2348 442912 An experimental heart treatment.
SGTC_3133 9127736 49.47 µM 0.0274141575839018 0.474367357533631 no 1567 0.48906470318695 2361 27243420
SGTC_626 0214-0009 33 µM 0.0257058362747123 0.475055305277492 no 1568 0.489745984361239 2343 3437874
SGTC_2303 7774051 200 µM 0.0252389382335873 0.475243339992566 no 1569 0.489932189310147 2348 2953184
SGTC_2991 9074669 71.4286 µM 0.0248228595545297 0.475410912779385 no 1570 0.490098128693536 2356 17333109
SGTC_208 k072-0098 12.366 µM 0.0246828765444531 0.475467290939931 no 1571 0.490153956729084 2369 5948901
SGTC_1347 1493-0251 600 nM 0.0223764865223343 0.476396259455047 no 1572 0.491073818346118 2371 3986378
SGTC_2676 harmalol 100 µM 0.0219667264465339 0.476561316316934 no 1573 0.491237248789516 2362 5459187 A monoamine oxidase inhibitor
SGTC_1518 st038567 90.8 µM 0.0215618067376641 0.476724427364674 no 1574 0.491398750125676 2368 77966
SGTC_23 0213-0011 39.996 µM 0.0196884654766347 0.477479102990437 no 1575 0.492145946107002 2358 627608
SGTC_2350 9023895 38.85 µM 0.0195855708593558 0.477520556457128 no 1576 0.492186987206499 2353 2997209
SGTC_1480 1070-0044 41.2 µM 0.0192955741336456 0.477637389625293 no 1577 0.492302657301154 2358 3124987
SGTC_2386 9075165 157.42 µM 0.0184615630412091 0.477973404641814 no 1578 0.492635320292725 2368 16452277
SGTC_219 mitoxanthrone 164.414 µM 0.018339571502417 0.47802255517331 no 1579 0.492683979637111 2350 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_660 4031-1742 102 µM 0.0181941477015304 0.478081147026878 no 1580 0.492741985661332 2372 6738706
SGTC_1037 k284-1091 78.7 µM 0.015610820104772 0.479122058228783 no 1581 0.49377243676997 2359 3334711
SGTC_2340 7987427 183.45 µM 0.0148522673868836 0.47942773247431 no 1582 0.494075020412069 2374 2239331
SGTC_2293 7624732 200 µM 0.0147162750240885 0.479482534647011 no 1583 0.494129267586504 2374 894453
SGTC_2051 5263410 176 µM 0.0136247724672831 0.479922402070848 no 1584 0.49456467036652 2389 227584
SGTC_3143 9086658 49.47 µM 0.0113784913783834 0.480827713010276 no 1585 0.495460736651979 2361 25236626
SGTC_420 mitomycin C 81.9 mM 0.00912960484921311 0.481734173074781 no 1586 0.496357865217492 2390 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2235 salicylic acid 500 µM 0.00888582145124144 0.481832440755 no 1587 0.49645511677644 2383 338 A COX inhibitor and kinase inhibitor.
SGTC_2963 9082507 9 µM 0.00866382029348098 0.481921929100402 no 1588 0.496543679014787 2391 16459611
SGTC_1077 5-fluorocytosine 377 nM 0.00783014790672518 0.482257989329012 no 1589 0.496876254858345 2385 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1675 st018485 24.5 µM 0.00721566001457155 0.482505702560655 no 1590 0.497121393118678 2347 3323024
SGTC_2406 ethylparaben 405.7 µM 0.00628313706695297 0.482881635405474 no 1591 0.49749340746291 2378 8434 A possible steroid mimic.
SGTC_2761 levamisole 97.89 µM 0.00593471551181027 0.483022100329796 no 1592 0.49763240495831 2402 26879 An alkaline phosphatase inhibitor.
SGTC_827 3253-0474 693 µM 0.00434959305954474 0.483661163211978 no 1593 0.49826476889747 2403 5402065
SGTC_471 1-acyl-paf 4 µM 0.00406773661390028 0.483774801773068 no 1594 0.498377212354417 2394 16759367
SGTC_1264 0783-0040 158 µM 0.00350144143354097 0.484003123994394 no 1595 0.498603129824105 2395 2855798
SGTC_3170 9103054 49.47 µM 0.00316072469407966 0.484140498705449 no 1596 0.498739055382334 2399 16432970
SGTC_1893 st059353 36.1 µM 0.000923616208737909 0.485042531896534 no 1597 0.499631530495859 2404 3112488
SGTC_2477 5967686 25.23 µM 5.86627076072194e-05 0.485391313925517 no 1598 0.499976596965666 2404 776118
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0 0.485414969359947 no 1599 0.5 2399 16725076
SGTC_2371 9071574 200 µM -0.000399773674062438 0.485576177395556 no 1600 0.499840513383073 2407 45596039
SGTC_867 0518-0118 155 µM -0.00147976680627909 0.486011694450802 no 1601 0.499409658671287 2408 6848158
SGTC_2284 7945075 39.21 µM -0.00171475512159383 0.48610645785472 no 1602 0.499315912016708 2410 1245402
SGTC_113 0099-0221 2.5 µM -0.00201677574225475 0.486228254432585 no 1603 0.499195423431747 2411 89219
SGTC_2394 5221648 200 µM -0.00226245816103243 0.486327332317141 no 1604 0.499097410551942 2415 788586
SGTC_3040 9091894 49.47 µM -0.00356230425518527 0.486851543275205 no 1605 0.49857884922269 2402 25236966
SGTC_2856 9022925 19.48 µM -0.00758982147515093 0.48847592862014 no 1606 0.496972128383179 2436 4944862
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.00905134905924054 0.489065443194061 no 1607 0.496389083470876 2438 676296 Flavone; oxidizing agent.
SGTC_922 1866-0035 480 µM -0.00941316480904367 0.489211387153286 no 1608 0.496244746022753 2434 3156169
SGTC_1979 st071809 45.3 µM -0.00955773896625613 0.489269703772891 no 1609 0.496187071873477 2452 4976333
SGTC_3070 9117005 49.47 µM -0.00972129867823582 0.489335678838312 no 1610 0.496121824020567 2425 8779016
SGTC_2240 6690706 185.951 µM -0.010603548285919 0.489691556764869 no 1611 0.495769875535791 2422 805876
SGTC_1727 st034309 9.9045 µM -0.0107147539802432 0.489736415011995 no 1612 0.495725513402756 2429 870305
SGTC_348 k064-0012 10.7 µM -0.0120442778293619 0.490272729361732 no 1613 0.495195144506343 2427 5066323
SGTC_1540 guanosine 70.6 µM -0.0120727795361663 0.490284226812469 no 1614 0.495183774797089 2420 6802 Guanosine is a purine nucleoside
SGTC_2472 5377652 49.4 µM -0.0121608208657113 0.490319742310124 no 1615 0.495148653966582 2445 1610903
SGTC_810 3825-7150 143 µM -0.0122356757180438 0.490349938499369 no 1616 0.495118793422767 2433 22330411 YGL099W LSG1
SGTC_1546 5-methoxyflavanone 78.7 µM -0.012789049201318 0.49057316915815 no 1617 0.494898046626901 2431 147795
SGTC_2066 5222451 176 µM -0.0130158854327555 0.490664675667363 no 1618 0.494807559595815 2428 2281147
SGTC_1798 st045719 60.953 µM -0.013775417737649 0.490971077138406 no 1619 0.494504577238668 2426 3980186
SGTC_1953 st076800 12.1 µM -0.0141000098280771 0.491102021846843 no 1620 0.494375096307566 2448 297591
SGTC_58 0957-0393 9 µM -0.0143292234170553 0.49119449019479 no 1621 0.494283662553685 2431 6997992
SGTC_966 1300-0360 30.2 µM -0.0145832426601212 0.491296966084294 no 1622 0.494182334126359 2435 70588
SGTC_1899 st063254 59.6 µM -0.0146602294688033 0.491328024048629 no 1623 0.494151624116351 2435 3093813
SGTC_2670 beta-carotene 100 µM -0.0151823763824326 0.491538669568056 no 1624 0.493943340826226 2444 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1073 triclabendazole 3.09 µM -0.0160543464428012 0.491890446650497 no 1625 0.493595517538331 2445 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2750 bromebric acid 70.15 µM -0.0169478920364786 0.492250934446751 no 1626 0.493239092961584 2455 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_601 0986-0029 62.9 µM -0.0184636433404188 0.492862456281184 no 1627 0.492634490514849 2444 24747981
SGTC_2653 dihydrofissinolide 100 µM -0.0186438858914332 0.492935175327668 no 1628 0.492562596516158 2458 6857746
SGTC_2952 9073731 13.78 µM -0.0189104360794628 0.493042715710571 no 1629 0.492456277121411 2439 16457353
SGTC_1487 3970-0795 2.82 µM -0.0194842458424387 0.493274222492631 no 1630 0.492227402327596 2457 3765103
SGTC_712 r015-0009 80.6 µM -0.0197588179684171 0.493385000970097 no 1631 0.492117884982233 2447 6813872 YLR060W FRS1
SGTC_1300 1094-0077 113 µM -0.0198487180144888 0.493421272025458 no 1632 0.492082027085087 2456 5532636
SGTC_2707 st078556 66.6 µM -0.0199798146176371 0.493474164333248 no 1633 0.492029737476794 2437 17250899
SGTC_899 1083-0020 478 µM -0.0202152040930576 0.493569134988117 no 1634 0.491935849625934 2451 767123
SGTC_1313 1220-0047 237 µM -0.0203400313599405 0.493619498166654 no 1635 0.491886060988602 2457 3528706
SGTC_2989 9073649 71.4286 µM -0.0206747359533279 0.493754539572234 no 1636 0.491752561250274 2444 21367202
SGTC_1214 0358-0031 63.7 µM -0.0213107114619504 0.49401113504198 no 1637 0.491498899634649 2482 4301366
SGTC_2868 9035608 32.47 µM -0.021591526588671 0.494124435623406 no 1638 0.491386896380134 2436 6462614
SGTC_2800 7887935 81.82 µM -0.0216292506913778 0.494139656217175 no 1639 0.491371850154346 2467 2961002
SGTC_506 n9-isopropylolomoucine 153 µM -0.0216679564778591 0.494155272901067 no 1640 0.491356412397592 2445 6610355
SGTC_2038 4100038 30.985 µM -0.0224844974031033 0.494484725988936 no 1641 0.491030739077591 2497 3596803
SGTC_1030 k029-0042 36.7 µM -0.0226171113531149 0.494538232639679 no 1642 0.49097784721649 2479 6080581
SGTC_2081 5214970 32.255 µM -0.0227738384461342 0.494601468510548 no 1643 0.490915338253439 2449 2063512
SGTC_396 dithiazanine 1.25 µM -0.0228245647881048 0.494621935482244 no 1644 0.490895106629818 2457 10578 An antihelmenthic.
SGTC_3146 9095609 49.47 µM -0.023733794032892 0.494988791984705 no 1645 0.490532474926018 2467 17173999
SGTC_1176 0848-0131 83.3 µM -0.0244030501184384 0.495258826660885 no 1646 0.490265557704352 2467 6769040
SGTC_2776 terbinafine 19.92 µM -0.0247113068416129 0.495383204309871 no 1647 0.490142618139996 2440 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0256350249985433 0.495755915422408 no 1648 0.489774224666922 2462 2374 Ca(2+)-ATPase inhibitor.
SGTC_787 4152-0075 138 µM -0.0267110987382328 0.496190105150162 no 1649 0.489345080389377 2481 9566539
SGTC_3017 9080681 49.47 µM -0.0267929830987642 0.496223145222337 no 1650 0.489312424943247 2488 16451914
SGTC_2925 9010536 32.5 µM -0.0268304618180211 0.49623826777187 no 1651 0.489297478470761 2478 2994177
SGTC_1734 st037168 69.4 µM -0.0268552196635664 0.496248257490413 no 1652 0.48928760507712 2514 708907
SGTC_3011 9081274 71.4286 µM -0.0273189907444097 0.496435388198252 no 1653 0.489102655048608 2479 6625322
SGTC_1288 0973-0013 65.5 µM -0.0275366004038872 0.496523193535499 no 1654 0.489015874003125 2492 4315430
SGTC_3233 9132340 49.47 µM -0.0276620944348411 0.496573830361362 no 1655 0.488965828192449 2465 17682950
SGTC_429 1112-0049 25.5 µM -0.0286475934134046 0.496971480930545 no 1656 0.488572826794546 2475 2836170
SGTC_1521 st012942 49.4 µM -0.0289909633450551 0.497110032028222 no 1657 0.488435898886265 2538 24207259
SGTC_531 3788-1495 174 µM -0.0294854997255672 0.497309579981902 no 1658 0.488238691728562 2463 2896655
SGTC_1763 st044482 94.5 µM -0.029700444346788 0.497396311446458 no 1659 0.488152978770899 2507 88505
SGTC_1159 4092-0538 61.2 µM -0.0298789504781965 0.49746833985203 no 1660 0.488081796719277 2447 717301
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0298977332811801 0.497475918842199 no 1661 0.488074306811185 2478 279621
SGTC_2258 7960471 200 µM -0.0305082427521283 0.497722264092443 no 1662 0.487830859838402 2503 2974708
SGTC_154 3389-1638 511.116 µM -0.0306903723323341 0.497795754946283 no 1663 0.487758234656526 2503 5238686
SGTC_1496 4469-0713 57.4 µM -0.0310691624975561 0.497948600276214 no 1664 0.487607191276756 2462 746691
SGTC_320 4092-0846 5.34 µM -0.0312106337815613 0.498005685324283 no 1665 0.487550779757717 2520 1359356
SGTC_2490 carminic acid 95.39 µM -0.0312909184725525 0.498038081001305 no 1666 0.487518766436119 2454 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_261 5-fluorouridine 15.376 µM -0.0316783182212919 0.498194400858481 no 1667 0.487364292880238 2483 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1437 4092-1038 11.6 µM -0.0319264581629877 0.498294528071738 no 1668 0.487265349414256 2461 3977136
SGTC_2289 7946404 165.07 µM -0.0320706087935679 0.498352694496588 no 1669 0.487207871066771 2467 1246120 YPR165W RHO1
SGTC_2223 6903751 107.57 µM -0.0322829694850927 0.498438384523055 no 1670 0.487123195254105 2493 5598863
SGTC_1186 1319-0216 26 µM -0.0324759276038931 0.498516245446739 no 1671 0.487046256445289 2480 4565136
SGTC_1222 0366-0074 1.18 µM -0.0325701064643667 0.498554247771334 no 1672 0.487008704381477 2479 286520
SGTC_3142 9086498 49.47 µM -0.0338428519393301 0.499067817316645 no 1673 0.486501232297887 2464 25236367
SGTC_2060 5238662 140 µM -0.034014952957896 0.499137262479458 no 1674 0.486432613432539 2503 790130
SGTC_322 k048-0136 19.3 µM -0.0344184591635271 0.499300082963517 no 1675 0.486271731954018 2522 6823282
SGTC_2041 5107442 45.335 µM -0.0345117002460593 0.499337707081983 no 1676 0.486234556229935 2467 793005
SGTC_2926 9010726 65.15 µM -0.0361530103814583 0.5 no 1677 0.485580176878102 2516 2994293
SGTC_2191 5911152 200 µM -0.037831427095942 0.499322734042664 no 1678 0.484911043550846 2477 2875902
SGTC_877 0771-0151 33.1 µM -0.0391765638886197 0.498779952776596 no 1679 0.484374809298188 2552 6166523
SGTC_2654 protoveratrine a 100 µM -0.0393034891559784 0.498728736779901 no 1680 0.484324212411649 2471 5702278 A heart drug and vasodilator.
SGTC_2388 9080168 200 µM -0.0395221092953248 0.498640520758997 no 1681 0.484237063308529 2481 15943073
SGTC_1785 bathophenanthroline 24 µM -0.0412383766665145 0.497947987586709 no 1682 0.483552929762787 2488 72812 An iron chelator.
SGTC_167 3672-0051 66.205 µM -0.0423999181477135 0.497479295926325 no 1683 0.483089946800367 2473 3237971
SGTC_1406 3909-7906 11.9 µM -0.0424426913893185 0.497462036629598 no 1684 0.483072898092873 2493 X1406
SGTC_963 1269-2853 151 µM -0.0430271102029558 0.497226220114401 no 1685 0.482839961521845 2509 3668223
SGTC_3161 9100388 49.47 µM -0.0432693921345794 0.497128458173565 no 1686 0.482743394950081 2488 25236368
SGTC_2920 7982904 15.77 µM -0.0433962412897544 0.49707727398931 no 1687 0.482692836948386 2527 6456808
SGTC_203 k066-0004 30.888 µM -0.0434464354148979 0.497057020455363 no 1688 0.482672831258023 2467 6795412
SGTC_1983 st071813 46.9 µM -0.0436167210815695 0.496988309552078 no 1689 0.482604961442991 2532 11838595
SGTC_145 3737-0113 38.366 µM -0.0437073494190353 0.496951740715305 no 1690 0.482568840413883 2528 6849351
SGTC_367 0335-0881 7.1 µM -0.0439121778278155 0.496869091863281 no 1691 0.482487204081257 2498 23828853
SGTC_1102 cgs 12066b 26.1 µM -0.0441534508021331 0.496771737696895 no 1692 0.482391043358589 2543 6438352 A 5-HT1B full agonist.
SGTC_3147 9097027 49.47 µM -0.0443079685567873 0.496709389549693 no 1693 0.482329459962231 2514 25236841
SGTC_1383 3049-0032 20.7 µM -0.0446228792941127 0.496582322842373 no 1694 0.482203952891082 2513 712864
SGTC_2177 5811945 192 µM -0.0456253729564284 0.49617781830526 no 1695 0.481804422766167 2522 5343475
SGTC_3151 9099821 49.47 µM -0.0458963854438276 0.49606846587158 no 1696 0.481696417570555 2548 17174189
SGTC_1027 k015-0025 8.67 µM -0.0461718081810012 0.495957334222803 no 1697 0.481586656157489 2493 3598955
SGTC_398 bronopol 33.3 µM -0.0463737408130814 0.495875855649867 no 1698 0.481506182892486 2501 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_673 1082-0474 110 µM -0.0464151059207479 0.495859165104893 no 1699 0.481489698352668 2487 3098046
SGTC_544 k015-0020 52.4 µM -0.0472598262497679 0.49551832771447 no 1700 0.481153073146357 2529 3008304
SGTC_1432 4049-0298 68.4 µM -0.0475467453733638 0.495402559046695 no 1701 0.481038737509658 2511 741646
SGTC_1220 1838-0075 193 µM -0.0484804496067014 0.495025822528395 no 1702 0.480666672536072 2510 5529645
SGTC_2447 5741742 33.78 µM -0.0496748633044191 0.49454389992295 no 1703 0.48019074394998 2547 1776504
SGTC_1198 1612-1005 86.7 µM -0.0504049706773543 0.494249319730176 no 1704 0.479899837697881 2557 6998509
SGTC_599 1935-0052 86.5 µM -0.0507386018002591 0.494114708892032 no 1705 0.479766908230169 2498 9557311
SGTC_1835 st008666 49.2 µM -0.0509108366139439 0.494045217217381 no 1706 0.47969828517008 2502 690455
SGTC_2671 danthron 100 µM -0.0514513375624733 0.493827142186627 no 1707 0.479482938726921 2523 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_343 4130-2827 29.8 µM -0.0515383501540968 0.493792035529763 no 1708 0.47944827171927 2526 1118244
SGTC_2035 5154463 94.595 µM -0.0520635991918488 0.493580116223637 no 1709 0.479239008623323 2512 2769623
SGTC_1046 2001-0062 216 µM -0.0521774320992282 0.493534188930827 no 1710 0.479193657504794 2502 739778
SGTC_1449 4112-4002 201 µM -0.0522416098218743 0.493508295673497 no 1711 0.479168089169054 2535 2059539
SGTC_211 3455-0679 143.504 µM -0.0532057695609719 0.493119297435726 no 1712 0.478783979341948 2541 748649
SGTC_1740 st038286 13.222 µM -0.0536876282046681 0.492924890001312 no 1713 0.478592019924345 2553 716786
SGTC_1946 st076057 65.1 µM -0.0538472460088695 0.492860492048179 no 1714 0.478528433612092 2507 953009
SGTC_1394 3474-0001 65.7 µM -0.054106162363924 0.492756032397825 no 1715 0.478425291292533 2553 5017666 YIL048W NEO1
SGTC_2986 9022445 71.43 µM -0.0551527543020678 0.492333790635606 no 1716 0.478008384105718 2489 6459286
SGTC_2895 9054447 58.44 µM -0.0561238377555442 0.491942020028658 no 1717 0.477621577040922 2506 2697450
SGTC_2327 6189656 200 µM -0.0567455446840328 0.491691204756471 no 1718 0.477373946515313 2553 5349088
SGTC_389 tpck 16.7 µM -0.0568691531602813 0.491641337768093 no 1719 0.477324713371597 2531 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1392 3455-1037 33.9 µM -0.0613611099782908 0.489829256270354 no 1720 0.475535811855443 2599 981132
SGTC_906 1165-0455 526 µM -0.0613739944164169 0.489824058897136 no 1721 0.475530681378045 2498 3252859
SGTC_427 1354-0053 47.3 µM -0.0616734627960333 0.489703258701989 no 1722 0.4754114366746 2751 6813657
SGTC_2147 5545932 89.7195 µM -0.0621393403423551 0.489515333903114 no 1723 0.47522593422637 2531 797404
SGTC_1569 carminic acid 40.6 µM -0.062423856915717 0.489400567290811 no 1724 0.475112648466961 2524 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_702 1488-0190 94 µM -0.0628273569369773 0.489237807346257 no 1725 0.474951990605915 2521 949357
SGTC_2360 9040895 200 µM -0.0631159806992934 0.489121386176296 no 1726 0.474837074456458 2546 4914414
SGTC_961 1252-1571 372 µM -0.0631776596395204 0.489096507075111 no 1727 0.474812517129663 2538 6813498
SGTC_2759 disulfiram 3.38 µM -0.0632064643820443 0.48908488827613 no 1728 0.474801048621103 2540 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_433 pimozide 108 µM -0.0638307500145874 0.488833076157736 no 1729 0.474552496603007 2509 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1971 st069429 63.5 µM -0.0643384993608132 0.48862827344323 no 1730 0.474350349442523 2524 1246522 YGL099W LSG1
SGTC_1472 k841-0093 193 µM -0.0662778807947932 0.487846044308917 no 1731 0.47357829653275 2618 X1472
SGTC_579 4491-1009 110 µM -0.0666543564988373 0.487694202112528 no 1732 0.473428435846752 2510 1271041
SGTC_946 3434-1334 87.4 µM -0.0666827598523299 0.487682746392033 no 1733 0.473417129702271 2605 4047976
SGTC_698 k064-0052 127 µM -0.0667077456657607 0.48767266905182 no 1734 0.47340718395013 2511 5088751
SGTC_3278 9139605 49.47 µM -0.0667945939957903 0.48763764122932 no 1735 0.473372613583081 2711 7958859
SGTC_2849 9019321 12.99 µM -0.0668000827118698 0.487635427513817 no 1736 0.473370428781779 2609 16489627
SGTC_2835 9006588 71.43 µM -0.0672393126778875 0.487458278001951 no 1737 0.473195594466545 2719 2345538
SGTC_2133 5320837 200 µM -0.0675029748432846 0.487351939394744 no 1738 0.473090646923472 2589 2841355
SGTC_598 3937-0236 20.2 µM -0.0680621770760328 0.48712640836588 no 1739 0.472868069413874 2579 1379313
SGTC_369 0957-0393 4.5 µM -0.0684210151287327 0.486981688083423 no 1740 0.472725246687751 2549 6997992
SGTC_512 prima-1 270 µM -0.0687483782249636 0.486849663224376 no 1741 0.472594954506974 2658 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1891 st059073 26.2 µM -0.0689684918424782 0.486760892667523 no 1742 0.472507349813144 2553 688754
SGTC_1120 ficusin 1.78878 µM -0.0689942107483573 0.486750520423317 no 1743 0.47249711383675 2661 6199 A DNA cross-linker.
SGTC_2012 4023501 200 µM -0.0696795721036037 0.486474122590006 no 1744 0.472224350677493 2564 3477460
SGTC_1187 1391-0724 117 µM -0.0702653083687892 0.486237907478513 no 1745 0.471991247072762 2571 6997986
SGTC_605 1315-0399 119 µM -0.070928242028704 0.485970566111438 no 1746 0.471727433043327 2611 24020461
SGTC_159 3970-0959 50 µM -0.0709295952494983 0.485970020404271 no 1747 0.471726894542617 2591 6615653
SGTC_1808 st050063 61.5 µM -0.0713454060335841 0.485802339538553 no 1748 0.471561429243724 2519 4011993
SGTC_3205 9113483 49.47 µM -0.0715977053905195 0.485700597909477 no 1749 0.471461033111851 2622 17018033
SGTC_2691 st077356 60.2 µM -0.0723533849692454 0.485395869983918 no 1750 0.471160340460193 2633 2839272
SGTC_2827 7993847 71.43 µM -0.072409129999627 0.485373391126009 no 1751 0.471138159590127 2589 2985692
SGTC_836 0330-0104 1.35 µM -0.0725142725995899 0.485330993113251 no 1752 0.471096323739563 2538 46494820
SGTC_1311 1190-0148 100 µM -0.0728171316318711 0.485208868270431 no 1753 0.470975819038142 2607 1961333
SGTC_485 niflumic acid 177 µM -0.0731053226965239 0.48509265942527 no 1754 0.470861153047614 2635 4488 A COX2 inhibitor.
SGTC_225 nsc-122657 1.016 µM -0.0742869062234109 0.484616216438162 no 1755 0.470391047781514 2652 275685
SGTC_401 neomycin 50 µM -0.0742998658525929 0.484610990923508 no 1756 0.470385891886148 2569 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_538 2922-0838 53.3 µM -0.0747951890409768 0.484411271258415 no 1757 0.470188834843177 2530 777039
SGTC_1348 1493-0373 93.8 µM -0.0751565306044581 0.484265576897377 no 1758 0.470045085021116 2586 3010129
SGTC_20 0481-0013 4.944 µM -0.0757199886515217 0.484038392562278 no 1759 0.469820936501039 2530 182045
SGTC_2506 ethyl hematommate 54.16 µM -0.0758848396034919 0.48397192620528 no 1760 0.469755359161203 2606 3940691 An allergen.
SGTC_3118 9124250 49.47 µM -0.0767080069842336 0.483640039542629 no 1761 0.469427917329753 2612 1504786
SGTC_3186 9110464 49.47 µM -0.0775450627692257 0.483302564943368 no 1762 0.469094972132512 2619 17018021
SGTC_1221 2958-7315 257 µM -0.0787419582703135 0.482820035114607 no 1763 0.46861893559802 2616 4562705
SGTC_905 2-aminofluorene 215 µM -0.0806565477634059 0.482048218722116 no 1764 0.467857547018682 2557 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2950 9072895 21.46 µM -0.08066184613043 0.482046082916834 no 1765 0.467855440140793 2600 17332245
SGTC_786 4544-0069 423 µM -0.0820115670858379 0.481502018810829 no 1766 0.467318757619402 2679 748821 YLR208W SEC13
SGTC_2956 9076196 2.52 µM -0.0821594364543509 0.481442415665499 no 1767 0.467259964684679 2563 16423868
SGTC_1486 3970-0793 4.53 µM -0.0829625665020529 0.481118697501066 no 1768 0.466940652284729 2642 2844330
SGTC_2847 9005661 71.43 µM -0.0845882819291303 0.480463457629808 no 1769 0.466294357671605 2545 2991449
SGTC_3091 9116372 49.47 µM -0.0849037443237651 0.480336317489592 no 1770 0.466168957499422 2704 17169793
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0854799004826789 0.480104115666328 no 1771 0.465939937035208 2567 16623 A steroid.
SGTC_120 rhodamine 6G 52.259 µM -0.0855777941536502 0.480064663335249 no 1772 0.465901025693292 2570 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2826 7992541 19.48 µM -0.0864751139853841 0.479703041759437 no 1773 0.465544369057759 2538 2985066
SGTC_1039 k821-0043 94 µM -0.0871189180935062 0.47944359777106 no 1774 0.465288494046354 2543 15992768
SGTC_2311 7694451 200 µM -0.0884321689125346 0.478914403305576 no 1775 0.464766597173924 2619 2163142
SGTC_2837 9008476 45.46 µM -0.0884485369939221 0.478907807769892 no 1776 0.464760092741861 2699 2992805
SGTC_2445 5742597 35.57 µM -0.0884982412515837 0.47888777942217 no 1777 0.464740341066956 2584 1774255
SGTC_2055 5235184 200 µM -0.0892747181788996 0.478574904730687 no 1778 0.464431792898991 2652 2836034
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0892755085594046 0.478574586260362 no 1779 0.464431478836832 2662 521171
SGTC_1265 0819-1001 68.8 µM -0.0894683287917827 0.478496893050371 no 1780 0.464354861290743 2537 3106768
SGTC_61 0978-8327 98.565 µM -0.0894918024409839 0.478487434849914 no 1781 0.464345534074472 2577 6150059 YHR072W ERG7
SGTC_1668 st014914 51.6 µM -0.0896190409101284 0.478436167065134 no 1782 0.464294976417112 2572 2839556
SGTC_1415 3966-0071 78.1 µM -0.0898600140815129 0.478339073503156 no 1783 0.464199228346438 2590 2893185
SGTC_1749 st037932 54.2 µM -0.0902702844796126 0.478173769205341 no 1784 0.464036216635551 2669 594497
SGTC_1205 4161-2785 76 µM -0.0905163198604559 0.478074639538913 no 1785 0.463938462907192 2709 3498106
SGTC_1578 josamycin 24.2 µM -0.0919420910340828 0.477500211575433 no 1786 0.463372024630143 2581 5282165 A P450 substrate.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0937565960434361 0.476769234658707 no 1787 0.462651255543449 2666 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2011 4012611 177 µM -0.0939377487520484 0.476696261183968 no 1788 0.462579303618346 2575 2049887
SGTC_2382 9035899 200 µM -0.0939550200214209 0.476689303865119 no 1789 0.462572443718127 2587 6462679
SGTC_1878 temozolomide 1 mM -0.0942825614846008 0.476557362947971 no 1790 0.46244235106133 2553 5394 DNA alkylating agent.
SGTC_603 3794-0023 45.9 µM -0.0950740281182956 0.476238553388115 no 1791 0.462128013585101 2585 3802260
SGTC_2792 7535235 81.82 µM -0.0958568037750306 0.475923259587888 no 1792 0.461817151065267 2651 1281891
SGTC_1138 3761-0006 1.03 µM -0.0963073983031115 0.475741771675569 no 1793 0.461638217703188 2550 12061087
SGTC_2247 cerulenin 830 nM -0.0965936902726865 0.475626463229534 no 1794 0.461524533748351 2784 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3015 9080845 49.47 µM -0.097040033182881 0.475446695907884 no 1795 0.461347301285601 2674 5296973
SGTC_2724 maprotiline 69.64 µM -0.0987958582774199 0.474739575521069 no 1796 0.460650178511119 2579 4011 A tricyclic antidepressant.
SGTC_1322 1348-1070 12 µM -0.099103114242841 0.474615842977499 no 1797 0.460528199727327 2570 6758089
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.099845644876535 0.474316834653863 no 1798 0.460233434855085 2770 94937 An inhibitor of serotonin biosynthesis.
SGTC_1877 wortmannin 25 µM -0.101037973024848 0.473836728516542 no 1799 0.45976015814338 2625 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3315 9136395 68.55 µM -0.103682688493371 0.472771936723313 no 1800 0.458710582591709 2595 16876844
SGTC_3299 9121982 43.1275 µM -0.103725155002842 0.472754840802019 no 1801 0.458693731760797 2615 17594604 YPL160W CDC60
SGTC_1921 5740136 50 µM -0.10424253797336 0.472546559803889 no 1802 0.458488438706551 2564 1774243
SGTC_1123 mangostin 811.285 nM -0.104754915600269 0.472340301186571 no 1803 0.458285142640545 2682 5281650 An antioxidant.
SGTC_1372 2752-0194 270 µM -0.107070067720653 0.471408425442918 no 1804 0.457366696565492 2594 823334
SGTC_2185 6113692 200 µM -0.108161530641355 0.470969152857322 no 1805 0.456933779990462 2693 874150
SGTC_1125 tnp00248 1.32998 µM -0.108685534824081 0.470758273488585 no 1806 0.456725957710574 2734 24207736
SGTC_536 3852-0578 10.6 µM -0.11007377349716 0.470199632827452 no 1807 0.456175433731443 2758 2869208
SGTC_2113 5491891 107.031 µM -0.110358743588975 0.470084965326904 no 1808 0.456062435531894 2609 789979
SGTC_1177 0983-0204 23.6 µM -0.110464867738081 0.470042263265286 no 1809 0.456020355399711 2667 766818
SGTC_2409 alverine citrate 63.97 µM -0.111657418159105 0.469562430579798 no 1810 0.455547521755441 2899 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_693 4161-2696 114 µM -0.111729630107579 0.469533376907627 no 1811 0.455518892495536 2713 805759
SGTC_1420 4'-methoxyflavone 42 µM -0.112144755642355 0.469366358929569 no 1812 0.455354315674224 2598 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_264 promethazine 12.5 mM -0.113803011454448 0.468699244846728 no 1813 0.454696975654882 2599 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3199 9111318 49.47 µM -0.114085266474698 0.468585702731958 no 1814 0.454585100806704 2693 8548020
SGTC_1570 verbenone 133 µM -0.114458075329029 0.468435737640492 no 1815 0.454437339484065 2691 29025 A natural terpanoid with antifungal properties.
SGTC_2497 7-hydroxyflavone 100 µM -0.114598626794887 0.468379200945608 no 1816 0.454381634099053 2774 5281894
SGTC_1679 SEC14.276 6.7 µM -0.114883323100426 0.468264684079925 no 1817 0.454268801901761 2768 1005053 YMR079W SEC14
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.115648269309158 0.467957003473944 no 1818 0.453965653076676 2601 688667
SGTC_2245 6637752 200 µM -0.116612725540796 0.467569102221134 no 1819 0.453583476503853 2760 681890
SGTC_1940 st075990 51.1 µM -0.117189798662434 0.467337019934097 no 1820 0.453354825352318 2871 1084979
SGTC_2823 7987624 58.44 µM -0.117784031491295 0.467098048108174 no 1821 0.45311939124505 2728 2239440
SGTC_931 2812-0076 566 µM -0.119482562666005 0.466415046356437 no 1822 0.452446527022065 2601 3450959
SGTC_2930 9013230 14.89 µM -0.119701667360262 0.466326948632542 no 1823 0.452359739747945 2683 2995857
SGTC_1776 st049249 45.9 µM -0.120261778485743 0.466101746383955 no 1824 0.452137890331062 2647 1822314
SGTC_2095 5432005 200 µM -0.120294044449242 0.466088773631946 no 1825 0.452125110848094 2660 783734
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.121349274186794 0.465664531213821 no 1826 0.451707196598356 2826 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1658 st012944 20 µM -0.122180348640475 0.465330435171909 no 1827 0.451378094678391 2673 24207260
SGTC_1421 4029-0249 71.4 µM -0.12320328703016 0.464919242452569 no 1828 0.450973061363881 2730 2894095
SGTC_1180 1193-0155 285 µM -0.123447594573862 0.464821043154739 no 1829 0.450876335122097 2721 2921347
SGTC_563 tetrahydrosecaminediol 614 µM -0.12483944920918 0.464261628915438 no 1830 0.450325327861002 2734 334274 A psychoactive constituent of the cannabis plant.
SGTC_1011 4112-3381 17.4 µM -0.12546746259208 0.464009240827362 no 1831 0.450076741271523 2803 2877139
SGTC_3062 9077494 49.47 µM -0.125962671785635 0.463810234732086 no 1832 0.449880736382245 2714 16459633
SGTC_636 0kpi-0074 126 µM -0.12605826630176 0.463771819904446 no 1833 0.449842901268633 2688 616434
SGTC_1845 st056753 3.01 µM -0.126116753266057 0.463748316979537 no 1834 0.449819753084612 2589 5375839
SGTC_539 4859-0462 2.54 µM -0.127850279310611 0.46305175916799 no 1835 0.449133729692681 2796 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3041 9091929 49.47 µM -0.128281698513517 0.462878425720624 no 1836 0.448963023952529 2752 25236887
SGTC_927 2425-1185 123 µM -0.12879215171008 0.462673347496598 no 1837 0.448761057917994 2606 730375
SGTC_1191 1487-1166 10.6 µM -0.129180264951747 0.462517426861249 no 1838 0.448607505822057 2749 3955771
SGTC_2207 7258803 200 µM -0.13008440691283 0.462154219196114 no 1839 0.448249823384538 2706 3666799
SGTC_2764 methyldopa 94.69 µM -0.131030039609655 0.461774377833698 no 1840 0.447875772044877 2746 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2851 9015922 71.43 µM -0.131360805918317 0.461641523967836 no 1841 0.447744946142119 2761 2996893
SGTC_1563 conessine 56.1 µM -0.131513126420568 0.461580345149905 no 1842 0.447684701689453 2733 441082 An anti-amoebic, histamine inhibitor.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.132105469582009 0.461342441942214 no 1843 0.447450434865639 2628 1241132 A phosphatase inhibitor.
SGTC_298 1391-0729 10 µM -0.132995821045818 0.460984875496257 no 1844 0.447098342731702 2640 3237558
SGTC_591 4299-0174 154 µM -0.133197910936654 0.460903720283086 no 1845 0.44701843147883 2680 5509088
SGTC_493 zm226600 134 µM -0.13353299651714 0.460769160280465 no 1846 0.446885935240718 2814 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3290 9121031 71.43 µM -0.134281766086213 0.460468493842353 no 1847 0.446589885603013 2673 17014854
SGTC_979 1426-2828 121 µM -0.135214054545779 0.460094167486888 no 1848 0.446221317611177 2754 747872
SGTC_1529 apigenin 74 µM -0.1354562607145 0.459996924226713 no 1849 0.446125572175067 2832 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1710 st031758 61.5 µM -0.135877420572305 0.459827838620852 no 1850 0.445959092840487 2802 5394341
SGTC_783 0848-0141 92.7 µM -0.136364517465946 0.459632289935097 no 1851 0.445766561285649 2635 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3137 9097352 49.47 µM -0.137392096992693 0.45921979254631 no 1852 0.445360438748462 2916 44120435
SGTC_102 gallobenzophenone 83.616 µM -0.138261231570553 0.458870933368398 no 1853 0.445016981955283 2780 70837
SGTC_3257 9139206 32.98 µM -0.138690666376798 0.458698575564395 no 1854 0.444847296984468 2759 4910041
SGTC_450 aminopyrene 156 nM -0.139577811399885 0.458342535971369 no 1855 0.444496786459742 2672 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_192 3455-0609 60.9 µM -0.139787209174675 0.458258502830127 no 1856 0.444414059831604 2763 3769639
SGTC_3103 9120822 49.47 µM -0.13989236101994 0.458216305186998 no 1857 0.444372518480867 2865 17141819
SGTC_1462 k081-0014 26.5 µM -0.141177846216709 0.457700475650305 no 1858 0.443864723465684 2675 3270634
SGTC_943 3253-1379 105 µM -0.141525601685734 0.45756094323811 no 1859 0.443727368184207 2781 668464
SGTC_3131 9127911 49.47 µM -0.142360034870596 0.457226159014041 no 1860 0.443397814182503 2884 45595681
SGTC_2680 butyl paraben 22.24 µM -0.14334355961538 0.456831596524802 no 1861 0.443009427710106 2647 7184 An antifungal and steroid mimetic.
SGTC_2416 tofa 880 nM -0.14557019250378 0.455938491801841 no 1862 0.442130350108395 2695 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_581 0958-0271 211 µM -0.145583043823018 0.455933337766307 no 1863 0.44212527721339 2643 4591145
SGTC_2774 tamoxifen 10.92 µM -0.145592511981998 0.455929540555612 no 1864 0.44212153978399 2655 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1829 berberine 14.4 µM -0.146272656559776 0.455656778726748 no 1865 0.441853075286912 2835 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2700 st077718 96.8 µM -0.148396759219524 0.454805074199459 no 1866 0.441014828762397 2737 904970
SGTC_3083 9117465 49.47 µM -0.148949381424144 0.454583522365432 no 1867 0.440796787525016 2766 16420915
SGTC_926 2268-1401 59.4 µM -0.149084456245134 0.454529371648873 no 1868 0.440743495467814 2662 2931578
SGTC_451 chloral hydrate 100 µM -0.14923530628282 0.454468897737853 no 1869 0.440683980767496 2779 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1625 st003711 30.1 µM -0.149345386954645 0.454424768426448 no 1870 0.440640551605983 2826 24207034 YER133W GLC7
SGTC_1061 3448-9325 110 µM -0.14955045934286 0.45434256018817 no 1871 0.440559648100493 2629 723482
SGTC_691 1548-0686 185 µM -0.150272118725378 0.454053281104302 no 1872 0.440274964609136 2689 46495133
SGTC_2958 9077254 16.72 µM -0.150917296027465 0.453794680695651 no 1873 0.440020478250763 2840 16457351
SGTC_2719 novobiocin 32.65 µM -0.151011271800027 0.453757014893873 no 1874 0.439983412129857 2747 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.152130079876858 0.453308624946463 no 1875 0.439542170004689 2648 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2945 9067681 61.76 µM -0.153084526554583 0.452926153909427 no 1876 0.439165809033453 2625 16456930
SGTC_971 1315-0384 26.7 µM -0.153607908691731 0.452716439903169 no 1877 0.438959450360536 2712 6769120
SGTC_2910 7948405 25.97 µM -0.154008400954278 0.452555975549086 no 1878 0.43880155580616 2763 2971328
SGTC_1056 3448-1962 115 µM -0.154269750396342 0.452451265419265 no 1879 0.438698523725029 2786 715507
SGTC_1821 st053465 65.6 µM -0.155083881708184 0.452125103454641 no 1880 0.43837759448882 2767 675086
SGTC_802 4112-3352 742 µM -0.158093556099055 0.450919632581776 no 1881 0.437191539123 2832 704594
SGTC_1676 st018489 23.4 µM -0.158681786629499 0.450684079957492 no 1882 0.43695979425604 2753 3696235
SGTC_3190 9110366 49.47 µM -0.159256557944757 0.450453933753851 no 1883 0.436733372801976 2747 17123768
SGTC_2745 rifampicin 24.3 µM -0.159989845538604 0.450160339684213 no 1884 0.436444536632889 2779 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1460 k062-0059 9.15 µM -0.160331641445226 0.450023500570267 no 1885 0.436309917503843 2608 1373085
SGTC_955 1216-0110 33 µM -0.16049528979432 0.449957985518628 no 1886 0.436245465866198 2655 3619719
SGTC_2702 st077768 96.8 µM -0.161313149625483 0.449630583631684 no 1887 0.435923383495627 2769 6484119
SGTC_3080 9117754 49.47 µM -0.161855136419732 0.449413636845031 no 1888 0.435709966415547 2870 9550191
SGTC_48 0382-0018 55 µM -0.16310798832031 0.448912202545247 no 1889 0.435216705129264 2941 762596
SGTC_1441 4106-0040 13 µM -0.163466347940367 0.448768789706103 no 1890 0.435075633591823 2680 2904180
SGTC_848 0368-0089 85.6 µM -0.164699299744341 0.448275422865933 no 1891 0.43459033408868 2776 762535
SGTC_1767 st044992 70.3 µM -0.166174319756128 0.44768529735591 no 1892 0.434009884157855 2744 9600693
SGTC_1684 st024538 14.6195 µM -0.168671961767375 0.446686306257598 no 1893 0.433027337009843 2711 6732859
SGTC_2575 plumbagin 510 nM -0.168976696019196 0.446564443598288 no 1894 0.43290748583933 2669 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2120 5538279 151.968 µM -0.170103870737748 0.44611373247038 no 1895 0.432464224736498 2733 2058197
SGTC_2589 lobaric acid 100 µM -0.170246383095685 0.446056752544973 no 1896 0.432408187836775 2737 73157 A novel microtubule depolymerizer.
SGTC_1490 4089-0339 670 nM -0.170868025677837 0.445808217683071 no 1897 0.432163769348513 2710 742542
SGTC_1477 0139-0234 16 µM -0.17201634837674 0.445349170348176 no 1898 0.431712338213784 2693 620880
SGTC_1867 st057372 64 µM -0.172933045268385 0.444982769063952 no 1899 0.431352028295057 2725 688837
SGTC_1282 0886-0010 32.4 µM -0.175627100447844 0.443906235622688 no 1900 0.430293455097031 2839 2836211 YNL267W PIK1
SGTC_2652 actinonin 100 µM -0.175785999896695 0.443842752897121 no 1901 0.430231034414274 2690 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2934 9036370 36.88 µM -0.175892898578739 0.44380004607261 no 1902 0.430189042243135 2827 6462800
SGTC_871 0574-0004 149 µM -0.177630077172702 0.443106122037361 no 1903 0.429506750998489 2726 9551173
SGTC_3288 9119690 36.221 µM -0.178753303948175 0.442657536635353 no 1904 0.429065706334964 2768 17595618 YKL019W RAM2
SGTC_765 1319-0117 244 µM -0.17901085634069 0.442554687741872 no 1905 0.428964588630371 2724 3487746 YGL099W LSG1
SGTC_2567 aureobasidin a 60 nM -0.179247648901378 0.442460132327737 no 1906 0.428871625561399 2993 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3001 9076041 71.4286 µM -0.179548956584951 0.442339819635396 no 1907 0.428753340021051 2727 16004211
SGTC_2045 5106652 78.05 µM -0.180485238681906 0.441965994520464 no 1908 0.428385820965026 2861 673349
SGTC_1007 4101-0031 70 µM -0.181262580254383 0.44165566811895 no 1909 0.428080738043087 2903 1146276
SGTC_2313 7726885 200 µM -0.181263043794902 0.441655483077295 no 1910 0.428080556130339 2833 726423
SGTC_3350 9150499 3.57 µM -0.181767315305896 0.441454189487442 no 1911 0.427882667893355 2714 4910996 YPR165W RHO1
SGTC_3055 9094636 49.47 µM -0.181921706051714 0.441392563273527 no 1912 0.42782208488569 2887 25236176
SGTC_1479 0549-0158 134 µM -0.182488255335115 0.441166433083135 no 1913 0.427599785246176 2774 5440202
SGTC_319 1348-1596 45.5 µM -0.184154047927742 0.440501666731585 no 1914 0.426946303661262 2925 5380505
SGTC_3232 9132874 49.47 µM -0.184213039509561 0.440478128076851 no 1915 0.426923165241469 2738 3784940
SGTC_126 0417-1624 672.48 µM -0.184470403332042 0.440375437951229 no 1916 0.426822221710166 2756 41912 YDL195W SEC31
SGTC_937 3122-0005 46.7 µM -0.184599806335534 0.440323806681743 no 1917 0.426771468927038 2894 759535
SGTC_1927 st060202 13.8 µM -0.185216347541819 0.440077823209212 no 1918 0.426529673720845 2696 688887
SGTC_1020 4335-0961 93.3 µM -0.185250646140555 0.440064139662691 no 1919 0.426516223302051 2693 669075
SGTC_1185 1319-0113 81.3 µM -0.18602687934197 0.439754477873227 no 1920 0.426211841281278 2845 4672763
SGTC_2970 9090938 41.86 µM -0.186678225464887 0.43949466556654 no 1921 0.425956464764488 2964 17217104
SGTC_3092 9117248 49.47 µM -0.186688413642476 0.439490601860332 no 1922 0.425952470481347 2742 17141857
SGTC_1232 0279-0259 161 µM -0.187626952142579 0.439116279219145 no 1923 0.425584548352108 2754 1560000
SGTC_3314 9135860 59.4275 µM -0.18893838431662 0.438593324527331 no 1924 0.425070554503475 2766 25252478
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.189904279135216 0.438208226913928 no 1925 0.42469206961258 2740 2724 A muscle relaxant with antifungal properties.
SGTC_290 2043-6722 48.1 µM -0.190014669613932 0.438164218480096 no 1926 0.424648817630881 2811 773758 YLR208W SEC13
SGTC_738 1315-0003 72.4 µM -0.190328404061216 0.438039148811527 no 1927 0.424525898609606 2902 6251474
SGTC_1791 st048313 56.1 µM -0.190425955074143 0.438000261537879 no 1928 0.424487680281961 2879 1204976
SGTC_2206 7254556 146.969 µM -0.191557987369188 0.437549037429527 no 1929 0.42404422709774 2792 4398905
SGTC_2701 st077767 14.721 µM -0.191962041452445 0.437388002521552 no 1930 0.423885969472105 2770 5721188
SGTC_2595 hexamethylquercetagetin 100 µM -0.192623236416966 0.43712450703854 no 1931 0.423627022844353 2849 386331
SGTC_1780 st038448 24.544 µM -0.192971417500661 0.436985763186861 no 1932 0.423490676437417 2943 728868 YDL195W SEC31
SGTC_923 1900-2434 73.3 µM -0.194357427112458 0.436433540469858 no 1933 0.422948011240143 2727 5910570
SGTC_2877 9040724 71.43 µM -0.196508716856044 0.435576655721183 no 1934 0.42210600530716 2953 6463895
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.197817963236242 0.435055314786984 no 1935 0.421593745631656 2807 4330530
SGTC_1098 clofazimine 15.1 µM -0.198161049476125 0.434918716730895 no 1936 0.421459530579071 2858 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2618 avocadyne 43.43 µM -0.198432816891676 0.434810519417438 no 1937 0.42135322186719 2775 3015189
SGTC_2754 granisetron 64.02 µM -0.198725595601645 0.434693962451871 no 1938 0.421238700470021 2885 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2659 sanguinarine 24.21 µM -0.199471069382182 0.434397210502379 no 1939 0.420947135945463 2750 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2677 mitomycin C 100 µM -0.199698922475527 0.434306516021458 no 1940 0.420858028270166 2776 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_150 3970-0969 77.2 µM -0.200126641753979 0.434136276289055 no 1941 0.420690768855538 2866 6615640
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.200718895893914 0.433900568985115 no 1942 0.420459191806624 2844 279621
SGTC_2560 caryophyllene 100 µM -0.203510111060738 0.432790029489792 no 1943 0.41936817177895 2748 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1688 st021091 57.6 µM -0.203534422536564 0.432780359012489 no 1944 0.419358671707636 2779 3656366
SGTC_739 1486-1183 203 µM -0.20516924991656 0.43213015956123 no 1945 0.418719946693862 2848 4346692
SGTC_3244 9134489 49.47 µM -0.205315937476321 0.432071828311227 no 1946 0.418662646495483 2841 16584271
SGTC_2417 cerulenin 830 nM -0.205662975124823 0.431933832460016 no 1947 0.418527090910857 2735 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2651 TUB2.036 5 µM -0.207042359579016 0.431385417085382 no 1948 0.417988388497206 2868 15992207 YFL037W TUB2
SGTC_168 3970-0862 530.542 µM -0.207737372349111 0.431109144093198 no 1949 0.417717017632735 2853 3135186
SGTC_2516 gossypol 71.55 µM -0.208954252080905 0.430625506163312 no 1950 0.417241975888089 2928 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_518 1021-0119 62.6 µM -0.209020021462636 0.430599369669624 no 1951 0.417216304474484 2823 1097762
SGTC_772 k072-0172 35.3 µM -0.209409690646352 0.430444522908324 no 1952 0.41706421421378 2802 5861980
SGTC_259 usnic acid 108.925 µM -0.209462048179665 0.43042371788343 no 1953 0.417043779694247 2962 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1301 naphtanilide LB 4.81 µM -0.209885086270471 0.430255624654667 no 1954 0.41687868120812 2905 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_730 1436-0052 41.2 µM -0.210243338591825 0.430113283787077 no 1955 0.416738878035798 2769 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2211 7117706 200 µM -0.210504935301425 0.430009351878083 no 1956 0.416636800072555 2859 822771
SGTC_1353 1498-1206 8.11 µM -0.211282575174613 0.429700425597232 no 1957 0.416333389508928 2774 6756808
SGTC_151 3013-0144 2.285 µM -0.211330862935239 0.42968124415265 no 1958 0.416314550788909 2999 906558 YHR107C CDC12
SGTC_1635 st007035 42.4 µM -0.214573258409779 0.428393642880428 no 1959 0.415050022499159 2780 3716403
SGTC_1548 st061468 90.8 µM -0.216407861649531 0.427665432512065 no 1960 0.4143349193754 2910 390799
SGTC_715 0868-0130 184 µM -0.216918709279811 0.427462705139697 no 1961 0.414135848417596 2941 2876258
SGTC_2252 omeprazole 400 µM -0.217121711462436 0.427382150035246 no 1962 0.414056747117549 2854 4594 A proton pump inhibitor.
SGTC_953 1188-0045 9.7 µM -0.218883915248022 0.426683001816159 no 1963 0.413370238219986 2915 6144426
SGTC_526 4469-0568 170 µM -0.219104184131402 0.426595627050624 no 1964 0.413284445747856 2765 2901964
SGTC_1468 k284-1086 134 µM -0.220740310386753 0.425946732623794 no 1965 0.412647321205341 2826 15996457
SGTC_1239 0337-0584 35.4 µM -0.220779887437023 0.425931038678515 no 1966 0.412631912334569 2959 914301 YML130C ERO1
SGTC_1524 corynanthine 62.1 µM -0.22138370159052 0.425691615834942 no 1967 0.412396840926969 2987 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2591 skatole 100 µM -0.221526519517437 0.425634990038668 no 1968 0.412341244948794 2937 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2855 9016525 58.44 µM -0.22179714917188 0.425527692452937 no 1969 0.412235899411671 2760 43811474
SGTC_3177 9107506 49.47 µM -0.222627488979847 0.425198518869329 no 1970 0.411912720102383 2920 8897194
SGTC_658 3253-0951 102 µM -0.222790470213413 0.42513391394589 no 1971 0.411849292642832 2852 1184878
SGTC_470 aa-861 153 µM -0.224319194555096 0.424528033571558 no 1972 0.411254470824474 2819 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2426 5582046 32.21 µM -0.224764810724547 0.424351455702589 no 1973 0.411081121308777 2959 2251934
SGTC_1910 st062352 60.4 µM -0.225983618205028 0.423868574159317 no 1974 0.410607080778743 2765 2245730
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.226588490102669 0.423628971255323 no 1975 0.41037187154853 2789 442882
SGTC_2450 5739737 12.93 µM -0.226973820547691 0.423476348208793 no 1976 0.410222049554994 2886 2262825
SGTC_1757 st041620 31.8375 µM -0.227147511574342 0.423407555804648 no 1977 0.410154520280205 2886 5289815
SGTC_400 oxethazaine 37.5 µM -0.228915882498 0.422707304637306 no 1978 0.409467147933013 2878 4621 A local anesthetic.
SGTC_1760 st045453 10.4495 µM -0.230553277524981 0.422059135824437 no 1979 0.408830934411817 2920 3323419 YIL048W NEO1
SGTC_2261 9010538 184.68 µM -0.231197265213107 0.421804268670645 no 1980 0.408580777251135 2941 6457250
SGTC_2272 7805186 180 µM -0.231371978298183 0.421735129161639 no 1981 0.4085129163328 2941 2956062 YPR165W RHO1
SGTC_2000 st075254 36.4 µM -0.231534912741255 0.421670653008813 no 1982 0.408449632869787 2822 17234175
SGTC_1410 3909-8106 77.9 µM -0.231709445374183 0.421601589568586 no 1983 0.408381847337708 2884 1039210
SGTC_638 3970-0837 4.09 µM -0.232763339728732 0.421184609593372 no 1984 0.407972590860477 2842 4118451 YLR208W SEC13
SGTC_1343 1487-0095 224 µM -0.234265818784792 0.420590297171956 no 1985 0.407389310143088 2880 4560101 YGL055W OLE1
SGTC_2080 5212524 12.4 µM -0.235394756718776 0.420143859632136 no 1986 0.406951177644462 2848 260183
SGTC_944 3370-0224 231 µM -0.236019837165307 0.419896716252297 no 1987 0.406708638566797 2863 4580514
SGTC_1365 1672-3266 55.4 µM -0.236702402186569 0.41962688078678 no 1988 0.406443835620424 2944 6415873
SGTC_3088 9117578 49.47 µM -0.237187127947929 0.419435279194559 no 1989 0.406255810920414 2869 678341
SGTC_2923 7992654 58.14 µM -0.238988717077789 0.418723317813883 no 1990 0.40555716587201 2869 2985126
SGTC_1484 3473-2379 286 µM -0.239002480527823 0.418717879723379 no 1991 0.405551829646611 2814 671917
SGTC_3171 9103192 49.47 µM -0.239432283656888 0.41854806760053 no 1992 0.405385199569877 2879 13018434
SGTC_597 k018-0003 82.8 µM -0.239779778048519 0.418410786162273 no 1993 0.405250492244785 2951 6786234
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.241589257712224 0.417696092513822 no 1994 0.404549223333798 2830 688664
SGTC_1456 k015-0012 13 µM -0.242623127118394 0.417287864977835 no 1995 0.404148681799151 2922 2989616
SGTC_631 k072-0230 41.5 µM -0.242646956456441 0.41727845691621 no 1996 0.404139451023345 2944 5773147
SGTC_2688 kanamycin b 96.69 µM -0.24318698728242 0.417065260039248 no 1997 0.40393027348632 2964 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_566 0958-0068 16.5 µM -0.243412992290681 0.41697604354864 no 1998 0.403842740020939 3011 6815365
SGTC_2100 5377183 190 µM -0.245662166996041 0.41608840545778 no 1999 0.402971880581915 2933 2844202
SGTC_1988 st071872 53.4 µM -0.245700101369438 0.416073438291774 no 2000 0.40295719686029 2964 16414116
SGTC_1737 st035557 69.7 µM -0.246119551930792 0.415907950433269 no 2001 0.402794844131563 2766 5716916
SGTC_2647 atorvastatin 60.16 µM -0.24660345931531 0.415717050637231 no 2002 0.402607563537355 2903 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1119 parthenolide 318.541 nM -0.24854638036645 0.41495077565008 no 2003 0.401855844626906 3057 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_851 0394-0702 453 µM -0.250038252042993 0.414362610875525 no 2004 0.401278883542374 2973 762646
SGTC_2138 5575593 77.673 µM -0.250738243093167 0.414086708138291 no 2005 0.401008245616708 2852 762213
SGTC_2250 alverine citrate 130 µM -0.251712925913364 0.413702605786581 no 2006 0.400631482599581 2793 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_788 1182-0090 188 µM -0.251930562683016 0.413616850896421 no 2007 0.400547367857123 3046 5715185
SGTC_253 dyclonine 31.25 µM -0.253574273245222 0.412969316935767 no 2008 0.399912237050676 2862 3180 An oral anasthetic.
SGTC_646 4092-0839 27.3 µM -0.254134809141979 0.412748549841174 no 2009 0.399695706061313 2994 877796
SGTC_1409 3909-8004 61.9 µM -0.254460783730753 0.412620177416623 no 2010 0.399569798599408 2885 2119279
SGTC_2521 angolensin 13.4 µM -0.256023787688904 0.412004779115371 no 2011 0.398966234696409 3003 821428 A flavenoid.
SGTC_495 decylubiquinone 155 µM -0.256171218527596 0.41194674261958 no 2012 0.398909315783413 2926 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1182 1222-0449 220 µM -0.256794411409504 0.411701442569462 no 2013 0.398668742247091 2924 658318
SGTC_2160 5660466 132.927 µM -0.258501955930312 0.411029499065577 no 2014 0.398009769799055 2850 2859134
SGTC_2151 5563267 85.4165 µM -0.258559176467816 0.411006986463337 no 2015 0.397987692380064 2893 5310824
SGTC_3214 9129694 49.47 µM -0.258655457411375 0.410969106764443 no 2016 0.39795054500885 3012 17158655
SGTC_2005 4024620 188 µM -0.258680556413044 0.410959232230007 no 2017 0.39794086139688 2853 236743
SGTC_305 1682-2595 20.8 µM -0.259208488864821 0.410751544337038 no 2018 0.397737190861357 2926 226033
SGTC_2634 4'-methoxyflavone 100 µM -0.260566648830397 0.410217361203884 no 2019 0.397213355878211 2937 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1889 st059080 5.18 µM -0.265327587404672 0.408346139528003 no 2020 0.395378557091513 3036 176925 Isolated from Daphnopsis sellowiana.
SGTC_256 clotrimazole 625 nM -0.266307449309575 0.407961275921156 no 2021 0.39500121823724 2937 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1708 st033234 31.827 µM -0.267343894629273 0.407554284490157 no 2022 0.394602196605087 3005 674664
SGTC_3225 9130819 49.47 µM -0.267762368869755 0.407389986238622 no 2023 0.394441119291733 3009 4547121
SGTC_1755 st041960 45.185 µM -0.268060995194834 0.407272751745212 no 2024 0.394326184358351 3001 2257073
SGTC_640 3381-0960 37.1 µM -0.270905219599976 0.406156586029586 no 2025 0.393231965217822 2948 1745025
SGTC_1374 2889-5571 141 µM -0.271280125723434 0.406009517397427 no 2026 0.393087795456979 2947 2853281
SGTC_3029 9088683 49.47 µM -0.272338945401687 0.405594234006504 no 2027 0.39268070668797 3038 25236615
SGTC_1003 4049-0218 100 µM -0.272950617546931 0.405354376305783 no 2028 0.392445588035109 3043 295161
SGTC_3087 9117406 49.47 µM -0.274678280858439 0.404677092298319 no 2029 0.391781709460653 3014 42546093
SGTC_574 1315-0397 40 µM -0.275352461529887 0.404412875199162 no 2030 0.391522731528089 2893 6794277
SGTC_1332 1480-0653 17.5 µM -0.275372489749254 0.404405026636935 no 2031 0.391515038677 3029 5749438
SGTC_812 4251-0442 148 µM -0.280754398099335 0.402297394200811 no 2032 0.389449391176136 3027 5723007
SGTC_3337 9144342 33.5465 µM -0.282424680729012 0.401643861624948 no 2033 0.388808946234674 2986 17682949
SGTC_2892 9047358 58.44 µM -0.283112746575151 0.401374721518428 no 2034 0.388545205404812 2956 6466771
SGTC_3121 9125696 49.47 µM -0.28446902006065 0.400844346045208 no 2035 0.388025486084493 2926 1235365
SGTC_1992 st073643 23.3 µM -0.285733782005624 0.400349921092882 no 2036 0.387541014297339 2873 3161292
SGTC_142 0335-0849 62.6745 µM -0.285919738298465 0.400277239882892 no 2037 0.387469797788416 2959 3889043 YPR107C YTH1
SGTC_3104 9120930 49.47 µM -0.285979828923022 0.400253754138117 no 2038 0.387446785423896 2989 17014836
SGTC_59 0330-0160 1.33 µM -0.28783419920951 0.399529172079803 no 2039 0.386736828734618 2945 4293482
SGTC_2546 rhodinyl acetate 100 µM -0.2887216437555 0.399182531634362 no 2040 0.386397199209098 3077 6708682
SGTC_817 1391-0715 46 µM -0.288978637717152 0.399082163288242 no 2041 0.386298862553635 2960 1353946
SGTC_81 0411-0046 9.971 µM -0.289872986620491 0.39873292961855 no 2042 0.385956704164112 2902 12925265
SGTC_8 0354-0001 70 µM -0.290965921229982 0.398306260445747 no 2043 0.385538691657848 2936 4993152
SGTC_2872 9044037 25.97 µM -0.291066022207567 0.398267188237477 no 2044 0.385500412874969 2899 6465195
SGTC_2022 5136654 200 µM -0.291272965946837 0.398186415548658 no 2045 0.385421280776116 3069 1713771
SGTC_2127 5253358 187.912 µM -0.291305074613797 0.398173883531575 no 2046 0.38540900334372 2851 20612
SGTC_3179 9107801 49.47 µM -0.293676353055949 0.397248664376974 no 2047 0.384502612725134 2913 4818259
SGTC_755 1995-0008 37.3 µM -0.294175204764543 0.397054097137073 no 2048 0.384312013266673 3018 689533
SGTC_2878 9043973 25.97 µM -0.295978066176904 0.396351140649343 no 2049 0.383623415995536 3069 6465167
SGTC_3076 9116187 49.47 µM -0.297309041034203 0.39583239415972 no 2050 0.383115289903898 3031 27241210
SGTC_3013 9080133 71.4286 µM -0.298640086680813 0.395313804531293 no 2051 0.382607337834292 3148 17050193
SGTC_2607 solasodine 47.35 µM -0.301070142839203 0.394367507303191 no 2052 0.381680503957369 2948 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2391 6285546 200 µM -0.301545613450682 0.394182425231327 no 2053 0.381499236552846 2904 846083
SGTC_2180 6301957 200 µM -0.301828111656276 0.394072471065084 no 2054 0.381391549842553 3063 845462
SGTC_1294 1000-1494 117 µM -0.302778407145453 0.393702658346129 no 2055 0.381029370040325 2960 712797 YDL207W GLE1
SGTC_2696 st077691 74.316 µM -0.302822761122623 0.39368540009059 no 2056 0.381012468246641 3097 757133
SGTC_1523 st012844 44.7 µM -0.302830114462378 0.393682538905876 no 2057 0.381009666160641 3046 4274103
SGTC_1606 st000094 49.2 µM -0.303368291987944 0.393473149607835 no 2058 0.380804603545699 3082 1242210
SGTC_237 nikkomycin 200 µM -0.303991697086859 0.393230639239377 no 2059 0.380567108389324 3077 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_957 1187-1561 14.1 µM -0.304490282446262 0.393036714715783 no 2060 0.380377197496937 2948 1538454
SGTC_2915 7971052 15.16 µM -0.306635635081615 0.392202584271295 no 2061 0.379560363287158 3000 5741558
SGTC_1452 4194-0072 190 µM -0.306829050601451 0.392127407027024 no 2062 0.379486747468692 3102 1343545
SGTC_1594 piperine 70.1 µM -0.308397756495165 0.391517827355613 no 2063 0.378889844446764 2934 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1139 k015-0024 46.9 µM -0.308619115555049 0.39143183137349 no 2064 0.378805639065824 3084 2766652
SGTC_711 k292-0785 179 µM -0.30885877638175 0.391338731303754 no 2065 0.378714478145687 2917 4146315
SGTC_3068 9116768 49.47 µM -0.308867794107436 0.391335228345901 no 2066 0.378711048162486 3057 41904888
SGTC_2802 7925815 54.55 µM -0.308931501374521 0.391310481351469 no 2067 0.378686816731065 2926 1262923
SGTC_1326 1431-2094 10.8 µM -0.311466331728781 0.390326188230063 no 2068 0.37772306710844 2899 616278
SGTC_1165 k072-0275 30.3 µM -0.312443702647801 0.389946855297688 no 2069 0.37735167080513 3071 6153523 YGL055W OLE1
SGTC_16 erodoxin 22.806 µM -0.313444451638612 0.389558557544139 no 2070 0.376971508446553 3063 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_917 harmaline 728.087 nM -0.313950046162798 0.389362425145216 no 2071 0.376779489607429 3058 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2372 9071633 200 µM -0.315257488153877 0.3888553674091 no 2072 0.37628307997082 3092 21321366
SGTC_2549 cedrol 20.94 µM -0.31566794832756 0.388696219988743 no 2073 0.376127278589042 3120 6708665 A sedative which affects the nervous system.
SGTC_907 3448-6986 75.5 µM -0.316067255430878 0.388541414864311 no 2074 0.375975730030323 3146 590582
SGTC_2334 9017922 200 µM -0.316676276757828 0.388305340906654 no 2075 0.375744625714459 3088 3163164
SGTC_1284 0929-0043 16 µM -0.316893498083704 0.388221149731313 no 2076 0.375662207875867 3013 1239883
SGTC_2755 lomerizine 42.69 µM -0.316960031851089 0.388195363460836 no 2077 0.375636964853429 2998 3949 A calcium channel blocker.
SGTC_569 4130-2812 160 µM -0.317515458087101 0.387980118007253 no 2078 0.375426255992715 2972 743552
SGTC_3277 9138724 49.47 µM -0.319046739197708 0.387386875934942 no 2079 0.374845535279383 3004 15943418
SGTC_1552 6-methylflavone 10.6 µM -0.32021731865942 0.386933552482162 no 2080 0.374401797735539 3023 689013
SGTC_2168 5727979 200 µM -0.320907150044262 0.38666647768993 no 2081 0.374140377666385 2941 695210
SGTC_2552 juarezic acid 87.02 µM -0.321224184856942 0.386543752634464 no 2082 0.374020252834395 2937 1549512
SGTC_2619 obliquin 87.91 µM -0.323720566398929 0.385577793776665 no 2083 0.373074799438176 2946 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1142 3253-1408 9.78 µM -0.325381348936337 0.384935557088785 no 2084 0.372446234792223 3086 256655
SGTC_2418 pentamidine 31.67 µM -0.325433768718382 0.384915291105818 no 2085 0.372426400736087 3064 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1952 st077036 64.1 µM -0.327198541404146 0.384233197106515 no 2086 0.371758862009829 2936 2937007
SGTC_3253 9135987 49.47 µM -0.327456514102192 0.384133519262037 no 2087 0.371661314107148 3097 4182430
SGTC_180 1486-1293 102.781 µM -0.32818682661412 0.383851376025889 no 2088 0.371385203795915 3120 4140536
SGTC_2947 9072639 7.68 µM -0.32889834531586 0.383576552641835 no 2089 0.371116262524278 3060 16488146
SGTC_359 0081-0058 15.9 µM -0.328916849824233 0.383569406074753 no 2090 0.371109268992004 3355 3494159
SGTC_2721 ifenprodil 61.44 µM -0.329757143416758 0.383244920743216 no 2091 0.370791736116592 3116 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1430 4049-0248 69.1 µM -0.330429582500229 0.382985312597724 no 2092 0.370537696008342 3111 22774488
SGTC_2699 st077704 54.6 µM -0.330740080143528 0.382865456690899 no 2093 0.370420412446371 3054 645852
SGTC_1446 4239-0190 62 µM -0.331947392535574 0.382399525952448 no 2094 0.369964491659477 3008 1340085
SGTC_604 1000-0114 314 µM -0.332546982101108 0.382168193205184 no 2095 0.369738134813068 3132 1572745
SGTC_1204 4049-0315 18.3 µM -0.333130286758769 0.381943183833416 no 2096 0.369517969146097 3228 588402
SGTC_2486 5283202 22.39 µM -0.333436143095865 0.381825215891747 no 2097 0.369402542166616 3028 1377751
SGTC_10 0279-0212 42.575 µM -0.334376443903747 0.381462613243765 no 2098 0.369047756248467 3007 39851 YBR002C RER2
SGTC_647 0140-0236 81 µM -0.337272711726109 0.380346397457663 no 2099 0.367955664346043 3041 990837
SGTC_2374 9071832 200 µM -0.337765273257426 0.380156664041686 no 2100 0.367770040682051 2961 17381698
SGTC_3353 9151644 39.2805 µM -0.338346854918369 0.379932677430343 no 2101 0.367550909206049 3113 4909158
SGTC_1512 0259-0544 12.2 µM -0.339004742338506 0.379679351456196 no 2102 0.367303078810024 3021 18476
SGTC_724 3910-0327 137 µM -0.33948243985088 0.379495441715498 no 2103 0.36712316173252 3077 2885483
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.34067720403394 0.379035586453539 no 2104 0.366673300852214 3115 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_666 0272-0154 136 µM -0.341017681551075 0.378904570663871 no 2105 0.36654513539453 3051 6870312
SGTC_775 4577-0580 57.3 µM -0.343063821589159 0.378117509250944 no 2106 0.365775223747712 3208 2006902
SGTC_2057 5236571 38.335 µM -0.343161259856144 0.378080041556637 no 2107 0.365738573602993 3176 54684039 YBR257W POP4
SGTC_3117 9124945 49.47 µM -0.343347755545061 0.378008332031409 no 2108 0.36566842907774 2940 17592065
SGTC_1314 1222-0010 41.1 µM -0.344163477968835 0.377694727730785 no 2109 0.365361673394567 3067 3526027
SGTC_3340 9146634 11.102 µM -0.344840256152918 0.377434601679012 no 2110 0.365107233597148 3111 4907387
SGTC_302 1094-0063 18.9 µM -0.345029326803079 0.377361940528511 no 2111 0.365036161684697 2987 5440289
SGTC_2318 6029776 164 µM -0.345734895489239 0.377090823978849 no 2112 0.364770978414696 3203 818325
SGTC_2798 7813637 45.45 µM -0.346540946050674 0.376781171156095 no 2113 0.364468108864707 3136 956368
SGTC_1777 st045864 34.765 µM -0.348548901460579 0.376010138908817 no 2114 0.363713997650242 3095 4691462
SGTC_2086 5274770 176.623 µM -0.348626007994006 0.375980540712669 no 2115 0.36368504988879 3085 689278
SGTC_1957 st077035 62.4 µM -0.349005349276036 0.3758349369903 no 2116 0.363542646819481 3140 705593
SGTC_2587 piperic acid 92.2 µM -0.352050403481188 0.374666786651184 no 2117 0.362400231258034 3066 5370536
SGTC_1126 isoteolin 1.0172 µM -0.353424139704208 0.3741401664754 no 2118 0.361885245583679 3005 133323
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.354968692240212 0.373548344478438 no 2119 0.361306522928626 3171 756377
SGTC_1017 4239-0030 168 µM -0.355109820681837 0.373494283519541 no 2120 0.361253659834676 3043 1149593
SGTC_342 k048-0088 23.3 µM -0.358065045626452 0.372362822192043 no 2121 0.360147318339101 3009 6820570
SGTC_2463 5473429 200 µM -0.358218008925014 0.372304287308271 no 2122 0.360090085559563 3082 5399405
SGTC_3203 9113543 49.47 µM -0.359482136355631 0.371820653255632 no 2123 0.359617219532989 3187 17018012
SGTC_2415 st077333 57.7 µM -0.359804969464421 0.371697175080307 no 2124 0.359496493327264 3272 2766255
SGTC_1620 st003704 16.5 µM -0.360197774834491 0.371546951505337 no 2125 0.359349619306921 3170 2834414
SGTC_1470 k295-0292 231 µM -0.360707111781346 0.371352190993848 no 2126 0.359159203859383 3142 5045612
SGTC_309 k408-0051 1.48 µM -0.362151048173585 0.370800237071658 no 2127 0.3586195790125 3098 3640463
SGTC_376 3970-0862 59.1 µM -0.363592666448745 0.370249434366524 no 2128 0.358081101916375 3163 3135186
SGTC_280 3448-3607 3.04 µM -0.363962308408537 0.37010824713097 no 2129 0.357943077680423 3154 626179
SGTC_2108 5365811 200 µM -0.363985464851735 0.370099402953914 no 2130 0.357934431686898 3158 780283
SGTC_2817 7995342 71.43 µM -0.364330254498794 0.369967725025218 no 2131 0.35780570512216 2987 18879975
SGTC_2229 7354935 190 µM -0.365512873944452 0.369516189072163 no 2132 0.35736429930675 3115 318112
SGTC_644 1498-1197 63.3 µM -0.367922619457528 0.368596681446004 no 2133 0.356465466779604 3143 6741615
SGTC_1663 st014140 55.4 µM -0.369264195197348 0.36808509014278 no 2134 0.355965405335363 3095 4207120
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.369524976728379 0.367985671842287 no 2135 0.355868229867125 3071 65057 A dermal irritant. YDR527W RBA50
SGTC_3222 9128301 49.47 µM -0.370026667231348 0.367794436172067 no 2136 0.355681310416247 3044 4911358
SGTC_1497 4476-2978 41.3 µM -0.370142405022144 0.367750323594771 no 2137 0.355638193845613 3129 1528379
SGTC_692 k241-0027 77.8 µM -0.371376816302501 0.367279945769131 no 2138 0.355178445388789 3223 3600480
SGTC_1900 st060200 72.8 µM -0.373423375038024 0.366500534568916 no 2139 0.354416682454939 3038 688945
SGTC_3320 9137005 35.139 µM -0.374378381758605 0.366137018010799 no 2140 0.354061412165531 3110 4908713
SGTC_2111 5486399 200 µM -0.37602667336297 0.365509890171853 no 2141 0.353448533157054 3070 689674
SGTC_713 1488-1073 324 µM -0.377007924524048 0.365136722681546 no 2142 0.353083857901581 3090 3312542
SGTC_1975 st070967 30.8 µM -0.378318146881348 0.364638647325056 no 2143 0.352597133106237 3233 261391
SGTC_2075 5212009 200 µM -0.379103687045887 0.364340137096292 no 2144 0.352305434221281 3199 780898
SGTC_1701 st028638 40.4 µM -0.381540217384263 0.363414764187416 no 2145 0.351401217402542 3188 3490878
SGTC_1853 st056710 91.2 µM -0.382484414071851 0.363056380368871 no 2146 0.351051043732925 3218 269167
SGTC_1163 k060-0048 49.9 µM -0.383046300747669 0.362843164846473 no 2147 0.350842717145275 3082 6809982
SGTC_297 0986-0032 24 µM -0.38446742009481 0.362304091701387 no 2148 0.350316019400971 3060 2847425
SGTC_326 k292-0812 17.5 µM -0.386646271240783 0.361478118517795 no 2149 0.349509048767882 3172 3579357
SGTC_2512 diallyl trisulfide 49.23 µM -0.386926676512103 0.361371867424168 no 2150 0.349405245699575 3147 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1251 0490-5699 265 µM -0.389775385636492 0.360293042609584 no 2151 0.348351323249268 3266 3883818
SGTC_3122 9126309 49.47 µM -0.390977276601069 0.359838211501804 no 2152 0.347907016155872 3180 17591206
SGTC_3193 9111931 49.47 µM -0.392367560223249 0.359312334555748 no 2153 0.347393325726265 3074 17087244
SGTC_1986 st071812 45 µM -0.393963945858645 0.358708827788265 no 2154 0.346803829040793 3175 11838594
SGTC_491 tetrandrine 80.3 µM -0.394263449391044 0.358595640995014 no 2155 0.346693272743153 3182 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2132 5317594 122.667 µM -0.394426956449284 0.35853385451112 no 2156 0.34663292258577 3054 794577
SGTC_883 0850-0245 24.6 µM -0.394773544213126 0.358402897246127 no 2157 0.346505010543614 3279 6823229 YPR165W RHO1
SGTC_1319 1306-0155 43.7 µM -0.395279184471206 0.358211872289867 no 2158 0.346318429814824 3111 3122360
SGTC_2598 perillyl alcohol 100 µM -0.395324086559986 0.358194910522439 no 2159 0.346301862792879 3235 10819 An apoptosis inducer.
SGTC_171 k064-0041 9.68 µM -0.395487667028443 0.358133120355214 no 2160 0.346241510822679 3101 53325
SGTC_1955 wogonin 32.4 µM -0.396004111187893 0.357938065398328 no 2161 0.346050997672422 3299 5281703 A flavanone.
SGTC_3153 9100258 49.47 µM -0.396575144402543 0.357722435960023 no 2162 0.345840392302407 3098 25236848
SGTC_703 3875-0075 71.8 µM -0.396783802396063 0.357643655357251 no 2163 0.345763448087318 3109 2850814
SGTC_3136 9095672 49.47 µM -0.396942430451314 0.357583768041396 no 2164 0.345704957052822 3118 17217380
SGTC_63 0099-0242 26.702 µM -0.397378614632436 0.357419112226233 no 2165 0.34554414154276 3220 3898502 YLR359W ADE13
SGTC_2581 avocatin a 64 µM -0.397829479268726 0.357248942558724 no 2166 0.345377942832242 3117 6710728 A skin care supplement.
SGTC_2520 obtusaquinone 4.71 µM -0.398053653594025 0.357164343092654 no 2167 0.345295318294211 3261 5967872
SGTC_1130 3454-2858 15.9 µM -0.399622232528066 0.356572585521072 no 2168 0.344717389377826 3139 715628 YIL048W NEO1
SGTC_79 0052-0007 94.094 µM -0.400085111845102 0.35639802688117 no 2169 0.344546914772122 3259 2801472
SGTC_1555 citronellol 128 µM -0.400220283859396 0.356347057187707 no 2170 0.344497137996481 3186 8842 A terpine precursor.
SGTC_2264 7948757 110.76 µM -0.40070912265676 0.356162750786956 no 2171 0.344317146745051 3044 2971411
SGTC_1561 5-methoxyflavone 52.9 µM -0.401766321475641 0.355764271136496 no 2172 0.343928005008553 3153 94525
SGTC_123 0083-0120 66.675 µM -0.401801199686421 0.35575112751466 no 2173 0.343915169586806 3125 16001701
SGTC_3201 9113999 49.47 µM -0.402414027352617 0.355520215473273 no 2174 0.34368967414346 3263 16649224
SGTC_2781 5567276 71.43 µM -0.403266584895691 0.355199061972425 no 2175 0.343376060437926 3261 2853274
SGTC_1276 0871-0068 94.2 µM -0.403381838764462 0.355155654390624 no 2176 0.343333672514101 3180 3414906
SGTC_554 4483-2211 187 µM -0.403654922130161 0.355052811650049 no 2177 0.343233246122231 3188 747107
SGTC_2452 5863136 48.41 µM -0.404554748445253 0.354714013310517 no 2178 0.342902413411792 3076 2184096
SGTC_2813 7971799 71.43 µM -0.404639489995243 0.35468211273889 no 2179 0.342871263292082 3196 2234054
SGTC_1906 st060206 94.7 µM -0.405265401158987 0.354446522898654 no 2180 0.342641217896478 3233 5133468
SGTC_1268 0828-0275 2.46 µM -0.40696599047038 0.353806710938591 no 2181 0.342016483551895 3216 745337
SGTC_1958 st076513 41.9 µM -0.407196067418887 0.353720180844246 no 2182 0.341931994852151 3096 732122 YGL099W LSG1
SGTC_1089 terbinafine 2.25 µM -0.407419858963148 0.353636021890044 no 2183 0.341849821867906 3220 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_745 0469-0705 296 µM -0.41015420225419 0.352608324666898 no 2184 0.340846417001265 3346 3486736
SGTC_2419 paclitaxel 166.5 µM -0.410831173206275 0.352354052251554 no 2185 0.34059816665624 3126 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1907 st060210 83.7 µM -0.410979627485383 0.352298301174659 no 2186 0.340543736580276 3261 688793
SGTC_1928 4'-methoxychalcone 40.3 µM -0.412195095891412 0.351841959072794 no 2187 0.340098215689645 3315 641818
SGTC_930 2810-3379 265 µM -0.414252611187893 0.351069960819747 no 2188 0.339344557669468 3327 1015764
SGTC_1978 st071761 42 µM -0.414546154807563 0.350959870608261 no 2189 0.339237086320941 3133 5147680
SGTC_2854 9024559 71.43 µM -0.414754627077145 0.350881693039868 no 2190 0.339160768992279 3213 3163529
SGTC_2002 4023503 131 µM -0.415044902420113 0.350772849650016 no 2191 0.339054516263772 3325 4736863 YCR052W RSC6
SGTC_845 0330-0138 4.51 µM -0.415432087222628 0.350627687568639 no 2192 0.338912810607553 3187 9039800
SGTC_1116 jasmonic acid 1.58368 µM -0.415616931502326 0.350558394034893 no 2193 0.338845167538527 3264 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2431 5490079 200 µM -0.415849921992653 0.350471058765326 no 2194 0.338759912947999 3190 5722345
SGTC_3037 9091026 49.47 µM -0.416231575666372 0.350328014956856 no 2195 0.338620278196789 3231 25236398 YIL048W NEO1
SGTC_1695 st026914 34.495 µM -0.416889344685492 0.350081532935614 no 2196 0.338379673823895 3118 3289191
SGTC_377 3970-0964 33.1 µM -0.417339733369562 0.349912797775109 no 2197 0.338214964846573 3144 16481235
SGTC_633 0437-0093 97.7 µM -0.417618746803967 0.34980828208919 no 2198 0.338112944023644 3146 2831118
SGTC_3248 9135562 49.47 µM -0.419186565892773 0.34922120432668 no 2199 0.337539894691154 3189 17650701
SGTC_3204 9114183 49.47 µM -0.419309472193307 0.349175196667692 no 2200 0.337494987439148 3085 17027248
SGTC_737 1950-0117 57.9 µM -0.419422266216599 0.349132976299697 no 2201 0.337453777026735 3253 5393513
SGTC_2844 9010103 25.97 µM -0.420108929160085 0.348875989133739 no 2202 0.337202940002325 3281 2480525
SGTC_2889 9059656 51.95 µM -0.422276307692552 0.348065291605749 no 2203 0.336411674661325 3226 3949838
SGTC_1886 st057356 49.9 µM -0.422625029992615 0.34793491841339 no 2204 0.336284430842085 3136 24207747
SGTC_1243 0416-0003 5.65 µM -0.422663586430579 0.347920504820792 no 2205 0.336270363295974 3150 2141977
SGTC_3175 9106517 49.47 µM -0.423339667131929 0.347667800607809 no 2206 0.336023728492855 3225 41468073
SGTC_1974 st069448 26.9 µM -0.423442728362907 0.347629284509856 no 2207 0.335986137867247 3270 6323587 YNR016C ACC1
SGTC_2508 celastrol 40.54 µM -0.423678801329846 0.347541065123259 no 2208 0.335900038630788 3183 122724 Celastrol is a natural product and antioxidant.
SGTC_2208 7283366 200 µM -0.426670659476159 0.346423738242565 no 2209 0.334809611989635 3246 898663
SGTC_293 4049-0273 38.5 µM -0.429202287677753 0.345479329137914 no 2210 0.333888009152328 3177 1380311
SGTC_1588 farnesol 29.9 µM -0.429350771120128 0.345423968039032 no 2211 0.333833986915788 3152 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_525 k781-2675 26.7 µM -0.429438167539781 0.345391384390485 no 2212 0.333802191377385 3264 3651118 YDL195W SEC31
SGTC_274 sirtinol 40.1 µM -0.429811384718377 0.34525225225733 no 2213 0.333666425320256 3194 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_981 1488-1094 54.9 µM -0.433916140199182 0.343723418331935 no 2214 0.332174669370325 3144 3449522
SGTC_637 1181-0519 7.26 µM -0.434624243560861 0.343459939607588 no 2215 0.331917597364445 3229 6252091 YGR060W ERG25
SGTC_746 1095-0025 46.6 µM -0.434987558157221 0.343324783111415 no 2216 0.331785729223353 3322 6749286
SGTC_519 k048-0011 62.8 µM -0.437225311245209 0.342492759912183 no 2217 0.330973977574399 3245 6836379
SGTC_1377 2944-0135 198 µM -0.438752940649399 0.341925207497801 no 2218 0.330420281156303 3226 1894137
SGTC_874 0599-0792 117 µM -0.439058382874018 0.341811770884671 no 2219 0.330309616665684 3326 765305
SGTC_1722 st034304 3.6505 µM -0.440815833346806 0.341159358169879 no 2220 0.329673165000764 3178 4036148 YLR033W RSC58
SGTC_37 0566-0070 1.56 µM -0.440820470264237 0.341157637448731 no 2221 0.329671486416155 3233 1626686
SGTC_372 0155-0182 15.9 µM -0.441583006539747 0.340874711595894 no 2222 0.329395491611427 3156 771486
SGTC_3006 9075424 71.4286 µM -0.442123972155229 0.340674049934615 no 2223 0.329199749130318 3185 7465181
SGTC_1558 st069300 45.6 µM -0.442226010074787 0.340636205818536 no 2224 0.329162833073164 3280 24208000
SGTC_482 fipronil 114 µM -0.442503956570842 0.340533128362691 no 2225 0.329062283918415 3246 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_530 4358-1714 28 µM -0.442526654462348 0.340524711294053 no 2226 0.329054073338108 3243 1564641
SGTC_857 0438-0306 1.35 µM -0.444687485152832 0.339723773775165 no 2227 0.328272807323129 3281 4686136
SGTC_162 k030-0015 37.8 µM -0.445985296241758 0.33924307203601 no 2228 0.327803933589912 3241 1809920 YMR134W ERG29
SGTC_1801 st050089 28.441 µM -0.446291574771403 0.3391296663491 no 2229 0.327693320700025 3256 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2726 cimetidine 79.27 µM -0.446607964994955 0.339012531910292 no 2230 0.327579071834342 3214 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1193 1488-0126 41.5 µM -0.448669657903767 0.338249630556336 no 2231 0.326834987934483 3199 1384710
SGTC_1329 1447-1697 50.6 µM -0.44869783135972 0.338239209942225 no 2232 0.326824824634694 3261 2840515
SGTC_2960 9079389 5.97 µM -0.448981938653354 0.338134133115868 no 2233 0.326722342877491 3324 16457355
SGTC_2513 baicalein 25.65 µM -0.450495408676937 0.337574590237239 no 2234 0.326176632017182 3230 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2267 7931562 200 µM -0.450614023144675 0.337530752599324 no 2235 0.326133878983461 3133 934880
SGTC_1114 scopoletin 1.73284 µM -0.451302013336246 0.337276528084209 no 2236 0.32588594699577 3302 5280460 A coumarin with genotoxic properties.
SGTC_2873 9040596 71.43 µM -0.451423753842567 0.337231550550454 no 2237 0.325842083211407 3307 6463863
SGTC_651 3253-0966 34.4 µM -0.454185912678353 0.336211685772243 no 2238 0.324847510762314 3214 781462
SGTC_457 grayanotoxin iii 135 µM -0.455499564336006 0.33572707164523 no 2239 0.324374940464382 3293 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3329 9141233 27.5565 µM -0.457459989075632 0.335004366967333 no 2240 0.32367022728703 3337 4909101 YNL103W MET4
SGTC_1109 tnp00067 928.257 nM -0.45897082661775 0.334447817620744 no 2241 0.323127557964839 3242 676295
SGTC_1703 st026983 48.3 µM -0.459050693387962 0.334418407095778 no 2242 0.323098881524207 3331 1104023
SGTC_1325 1431-0015 227 µM -0.459081038252829 0.334407233022668 no 2243 0.323087986370915 3195 1103340
SGTC_2225 6654152 15.4 µM -0.461486704237183 0.33352184764773 no 2244 0.322224729136685 3261 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2037 5169046 200 µM -0.46180786663769 0.333403716490904 no 2245 0.322109554532853 3298 5718022
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.462460523135217 0.333163704842516 no 2246 0.32187555282843 3171 23665772 A membrane-active detergent.
SGTC_2467 5474540 200 µM -0.462948956002378 0.332984130419565 no 2247 0.321700477617818 3193 5413519
SGTC_385 1494-0393 12.4 µM -0.464096976490633 0.332562206640239 no 2248 0.321289133934633 3233 3090647
SGTC_1812 st052057 4.327 µM -0.464112222792446 0.332556604701199 no 2249 0.321283672552495 3200 3645418
SGTC_951 1171-0579 82.7 µM -0.464715392442712 0.332335012471904 no 2250 0.321067641995891 3267 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2117 5521686 200 µM -0.464904931756432 0.33226539168921 no 2251 0.320999769309898 3194 803312
SGTC_3228 9131799 49.47 µM -0.465298185651635 0.332120961788761 no 2252 0.320858966953574 3260 17015818
SGTC_2181 6316240 54.2555 µM -0.465855128902485 0.331916456555895 no 2253 0.320659600621733 3291 12779990
SGTC_89 0302-0250 142.109 µM -0.465948758402675 0.331882081445431 no 2254 0.320626089590916 3315 4203518 YLR208W SEC13
SGTC_49 0717-0965 32.132 µM -0.467034349414873 0.331483621233942 no 2255 0.32023765139518 3454 5889349 YGL099W LSG1
SGTC_397 arbidol 50 µM -0.467160314650519 0.331437398722876 no 2256 0.3201925921822 3350 131410 A RNA synthesis inhibitor.
SGTC_1863 st057641 20.1 µM -0.468168080065704 0.331067695142397 no 2257 0.319832198414986 3305 3921635
SGTC_838 0109-0203 71.4 µM -0.468357139227958 0.330998356211512 no 2258 0.319764606625139 3254 759422
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.468568425078673 0.330920872326788 no 2259 0.319689075506739 3323 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3167 9103034 49.47 µM -0.472492938308952 0.329482973295302 no 2260 0.318287490517083 3323 5127859
SGTC_1345 1488-0192 31.4 µM -0.473548028202947 0.329096828337263 no 2261 0.317911122101685 3343 658348
SGTC_1629 st005085 44.9 µM -0.474610534986222 0.328708153119077 no 2262 0.317532297944295 3193 24207091
SGTC_1411 3909-8223 150 µM -0.474627694715954 0.328701877443311 no 2263 0.317526181412971 3330 X1411
SGTC_88 0180-0332 8.668 µM -0.474657097322923 0.328691124400934 no 2264 0.317515701062633 3225 3101745
SGTC_3321 9137793 26.8275 µM -0.475187733757845 0.328497085856104 no 2265 0.317326584621867 3320 4904192
SGTC_1666 st014829 29 µM -0.47608454916199 0.328169251291135 no 2266 0.3170070720506 3256 3858230
SGTC_2092 5303694 80.6725 µM -0.476325067194007 0.328081351423374 no 2267 0.316921404765163 3237 1963699
SGTC_3317 9138495 8.753 µM -0.476348031965106 0.328072959201831 no 2268 0.316913225726974 3310 17020139
SGTC_1318 1280-3875 124 µM -0.47659874191998 0.327981345669057 no 2269 0.316823939724067 3293 373245
SGTC_2785 7756463 72.73 µM -0.476857985462447 0.327886624706734 no 2270 0.316731625850793 3203 2201551
SGTC_144 4161-2749 112.381 µM -0.477096065938126 0.327799645939801 no 2271 0.316646857972861 3258 797501 YMR168C CEP3
SGTC_3331 9141060 1.957 µM -0.478371990171744 0.327333667381978 no 2272 0.316192732924169 3222 4906567 YPR165W RHO1
SGTC_166 k072-0058 166.424 µM -0.478515367050892 0.327281321701489 no 2273 0.316141719747204 3385 5846229
SGTC_200 k038-0079 37.545 µM -0.47876599043436 0.327189829391358 no 2274 0.316052556907 3228 3436683
SGTC_330 1488-0319 80.1 µM -0.479157451534484 0.327046943787146 no 2275 0.31591331044845 3310 6846614
SGTC_2763 lisinopril 49.32 µM -0.479848290125414 0.32679484548795 no 2276 0.315667636275269 3357 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2777 climbazole 1.536 µM -0.481055283814971 0.326354583500186 no 2277 0.31523860386985 3315 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2304 7443016 91.4 µM -0.481284499248872 0.326271002378337 no 2278 0.31515715613262 3278 939854
SGTC_1603 st002045 67.8 µM -0.481577148135688 0.326164303560574 no 2279 0.315053181474557 3356 5887985
SGTC_958 1222-0007 33 µM -0.482319585071232 0.325893677358187 no 2280 0.314789468243462 3394 7312461
SGTC_2017 5132927 60.65 µM -0.48251589037245 0.325822137299539 no 2281 0.314719756475884 3217 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1626 st003712 1.76 µM -0.485778508804164 0.324634073362396 no 2282 0.313562106642032 3362 24207035
SGTC_1292 0kpi-0043 232 µM -0.48725530621002 0.324096891126648 no 2283 0.313038708126476 3303 3333905
SGTC_2277 7947813 106.88 µM -0.487318749786878 0.324073821839193 no 2284 0.313016231226809 3423 1246798
SGTC_855 0428-0020 25 µM -0.487966401201767 0.323838362165159 no 2285 0.312786819935535 3270 6812414
SGTC_1954 st077032 68.9 µM -0.488700478229863 0.323571566875191 no 2286 0.312526882585249 3304 698907
SGTC_3335 9143315 29.6265 µM -0.48974454977775 0.323192262387952 no 2287 0.312157336521872 3258 4899691
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.491149028890491 0.322682314016292 no 2288 0.311660523295919 3269 6708784 An antioxidant flavonoid
SGTC_936 3005-4620 401 µM -0.491273910325312 0.322636987289791 no 2289 0.311616364952941 3420 777207
SGTC_972 1319-0219 195 µM -0.492280834083576 0.322271612515184 no 2290 0.311260413582741 3311 23903702
SGTC_3005 9076496 71.4286 µM -0.493723790381504 0.321748317222533 no 2291 0.310750630639344 3349 21368410
SGTC_723 4182-0001 115 µM -0.494066510954866 0.321624079795791 no 2292 0.310629603996107 3271 744821 YLR208W SEC13
SGTC_2773 thioridazine 9.09 µM -0.495712976678865 0.321027508394872 no 2293 0.310048465132429 3352 5452 An antipsychotic.
SGTC_2194 5927483 104.545 µM -0.496368304137625 0.320790188982403 no 2294 0.309817291671328 3283 760979
SGTC_2544 sphondin 68.51 µM -0.497863656047437 0.320248938495817 no 2295 0.309290072631718 3418 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_888 0916-0002 6.97 µM -0.498811343405667 0.319906115862252 no 2296 0.308956147783002 3411 2802138 YIL048W NEO1
SGTC_3263 9137018 49.47 µM -0.500063549410336 0.319453370482702 no 2297 0.308515165537539 3314 43844957
SGTC_704 1310-0270 142 µM -0.500517762040932 0.319289212621766 no 2298 0.308355276265168 3327 5718033
SGTC_1963 st076565 50.3 µM -0.50055852540719 0.31927448198668 no 2299 0.308340928760414 3272 4914280
SGTC_2219 9098279 200 µM -0.500885128753274 0.319156467817987 no 2300 0.308225984569394 3363 902349
SGTC_1511 0906-3109 28.5 µM -0.503543159861734 0.318196702714906 no 2301 0.307291221901249 3360 2882180
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.503679832516971 0.318147385693429 no 2302 0.30724319132153 3378 364106
SGTC_1999 st074831 12.5 µM -0.503862451999007 0.318081494230406 no 2303 0.30717901890696 3278 17112523
SGTC_777 1315-0167 517 µM -0.50447593781018 0.317860182810488 no 2304 0.306963483477309 3326 4221767
SGTC_1868 st057644 42.7 µM -0.504641451821297 0.317800485736773 no 2305 0.306905345007353 3262 688665
SGTC_2149 5554786 194.827 µM -0.506772723418144 0.317032208934903 no 2306 0.306157148561905 3299 745063 YPR165W RHO1
SGTC_1919 st067113 52.3 µM -0.50717770733933 0.31688631009308 no 2307 0.306015067622254 3377 1268243
SGTC_285 1486-1325 46 µM -0.507349734759672 0.316824344391495 no 2308 0.30595472388857 3400 22310230
SGTC_720 r052-1644 49.9 µM -0.508416086621911 0.316440350321574 no 2309 0.305580786813957 3368 1422863 YOR257W CDC31
SGTC_954 1189-0853 2.85 µM -0.509379107394498 0.316093735807796 no 2310 0.305243258959609 3376 2828194
SGTC_260 nsc-65238 3.989 µM -0.511069943287194 0.315485554013719 no 2311 0.304651040763045 3355 3246252
SGTC_2689 tacrolimus 100 µM -0.512005958871454 0.315149090457927 no 2312 0.304323419574386 3350 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1195 1502-0147 41.1 µM -0.513337893501245 0.314670572712363 no 2313 0.303857490727436 3355 817940
SGTC_140 0062-0056 502.533 µM -0.515574209732823 0.313867842028332 no 2314 0.303075913432625 3277 3758964
SGTC_1896 st058441 89 µM -0.516031343820436 0.313703860955767 no 2315 0.302916258955149 3305 688759
SGTC_2104 5389443 200 µM -0.516139473497961 0.313665078547285 no 2316 0.302878500077537 3459 2244536
SGTC_90 0870-0863 4.608 µM -0.51703854603341 0.313342691825971 no 2317 0.302564625630606 3321 1738164
SGTC_3078 9116413 49.47 µM -0.517708068969301 0.313102708910668 no 2318 0.302330983799545 3294 17177322
SGTC_1210 3013-0140 750 nM -0.517936519386597 0.31302084155094 no 2319 0.30225128052302 3407 905973
SGTC_3045 9092950 49.47 µM -0.519637686031229 0.312411502568968 no 2320 0.301658063144582 3448 44120432
SGTC_1036 k216-0215 33.5 µM -0.519944852500261 0.31230153353919 no 2321 0.301551006313277 3389 622330
SGTC_878 0828-0289 13.7 µM -0.520709290283096 0.312027928856341 no 2322 0.301284650793302 3348 745350 YLR208W SEC13
SGTC_3272 9137413 49.47 µM -0.520994722734835 0.311925794524836 no 2323 0.301185223817545 3351 17614870
SGTC_2487 5918373 44.05 µM -0.521830727030122 0.311626736073961 no 2324 0.300894096822306 3476 2876279
SGTC_643 k048-0106 28.4 µM -0.523127089461076 0.311163242340364 no 2325 0.30044290760484 3400 6763920
SGTC_1618 st003135 44.5 µM -0.523463881258516 0.311042876745798 no 2326 0.300325739779863 3363 1270615
SGTC_2612 dictamnine 15.46 µM -0.524070983189799 0.310825956407802 no 2327 0.30011458487774 3337 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1229 0139-0193 12.2 µM -0.525679714729285 0.31025146716672 no 2328 0.299555380171743 3448 3090752
SGTC_204 PMA1.184 62.41 µM -0.526532766187299 0.309947024187603 no 2329 0.299259046103059 3347 2252213 YGL008C PMA1
SGTC_2534 helenine 20.12 µM -0.52660876410754 0.309919907834481 no 2330 0.299232652305122 3369 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_236 1509-0011 5.31 µM -0.528438481370322 0.30926737001633 no 2331 0.298597517344621 3489 3107280
SGTC_96 0929-0093 37.281 µM -0.529903370348683 0.308745375202871 no 2332 0.298089464633663 3330 6991579
SGTC_271 rotenone 740 µM -0.530453772334557 0.308549346104473 no 2333 0.297898676093793 3447 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1188 1403-0014 4.57 µM -0.53333537123695 0.307523938214962 no 2334 0.296900723379754 3358 9614867
SGTC_2679 rapamycin 1 nM -0.534875455096394 0.306976519643701 no 2335 0.296367990972411 3400 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2040 5100729 123 µM -0.536545018886701 0.30638356354628 no 2336 0.295790965551338 3349 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2975 9084847 53.72 µM -0.538051536089444 0.30584894922594 no 2337 0.295270734804249 3386 27211724
SGTC_2359 9039622 200 µM -0.538984647888579 0.305518025233423 no 2338 0.29494872384027 3378 6463596
SGTC_394 menadione 8.33 µM -0.539733110706236 0.305252700959647 no 2339 0.29469055107937 3427 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1553 gossypol 38.6 µM -0.543246999715423 0.304008423771164 no 2340 0.293479875217535 3389 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1660 st012960 28.1 µM -0.544152216749174 0.303688250708363 no 2341 0.293168365185899 3393 24207266
SGTC_1673 st016611 27.3 µM -0.544663430371242 0.303507502217646 no 2342 0.292992510312855 3466 5226799
SGTC_1661 st013063 9.66 µM -0.545148294022205 0.303336114629723 no 2343 0.292825764932573 3410 721395
SGTC_3200 9114385 49.47 µM -0.546884815969745 0.302722651253881 no 2344 0.292228934016571 3451 17018030 YLR208W SEC13
SGTC_459 nigericin 15.3 µM -0.548389170040333 0.302191655842318 no 2345 0.291712355569633 3480 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1429 4049-0205 9.46 µM -0.549935004298379 0.301646454991182 no 2346 0.291181977063214 3463 22774478
SGTC_2048 5246248 200 µM -0.550047133585554 0.301606925285088 no 2347 0.291143522824335 3465 677046
SGTC_2329 6138490 200 µM -0.551611280898248 0.301055748852771 no 2348 0.290607352921158 3438 720019
SGTC_2793 7325131 81.82 µM -0.55434516677672 0.300093470204252 no 2349 0.289671322415561 3372 4176441
SGTC_3283 9109332 35.8195 µM -0.555183493613253 0.29979867319241 no 2350 0.289384579009685 3334 17027281
SGTC_1731 st035964 63 µM -0.555897944519209 0.299547540605531 no 2351 0.289140311740634 3351 6739575
SGTC_3085 9117376 49.47 µM -0.556169060910081 0.299452266981163 no 2352 0.289047643755601 3453 16480349
SGTC_1892 st058411 7.36 µM -0.557590216072105 0.298953080542982 no 2353 0.288562119494853 3445 3934738
SGTC_2884 9058502 51.95 µM -0.557711978570792 0.298910328562261 no 2354 0.288520538362777 3464 6471554
SGTC_110 0850-0284 111.64 µM -0.558055465462555 0.298789741991969 no 2355 0.288403254955538 3365 3906265
SGTC_2712 st079126 47.7 µM -0.559676995792971 0.298220776601512 no 2356 0.287849888035159 3407 3152970
SGTC_276 colchicine 750 µM -0.56099902690129 0.297757265474779 no 2357 0.287399100277558 3504 2833 A microtubule depolymerizer.
SGTC_2468 5987765 72.9 µM -0.561402148838319 0.297615994193519 no 2358 0.287261709741081 3399 26772094
SGTC_2470 5664817 21.68 µM -0.561540513111239 0.297567512448502 no 2359 0.287214560104341 3471 2859561
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.564087855717798 0.296675588704802 no 2360 0.286347171270072 3470 66535 A nucleotide analog.
SGTC_2834 9001755 58.44 µM -0.566641158004824 0.295782808852207 no 2361 0.28547900297514 3324 2989575
SGTC_1643 st009866 20.2 µM -0.567672713777866 0.295422468614614 no 2362 0.285128611390391 3457 3156273 YOR207C RET1
SGTC_719 2810-4230 27.3 µM -0.570383189692986 0.294476616340746 no 2363 0.284208914298612 3434 721079
SGTC_1702 st027038 51 µM -0.570560863578698 0.294414663804081 no 2364 0.284148676980255 3459 5521182
SGTC_2783 7738165 71.43 µM -0.571902051213078 0.293947203656281 no 2365 0.283694167159105 3396 17201110
SGTC_2227 7312221 64.1025 µM -0.572319773285502 0.293801680118606 no 2366 0.283552678109403 3475 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3110 9122132 49.47 µM -0.573215845480582 0.293489624296049 no 2367 0.283249278449131 3555 918317
SGTC_184 1494-0393 24.714 µM -0.574068355773579 0.293192881420279 no 2368 0.282960772963625 3403 3090647
SGTC_1881 5652484 16 µM -0.574573684524938 0.293017051633537 no 2369 0.282789826854959 3474 2255129
SGTC_294 k038-0071 157 µM -0.575362509227709 0.29274267689639 no 2370 0.282523076982267 3460 24152826
SGTC_3326 9140064 16.379 µM -0.575414398856137 0.29272463245195 no 2371 0.282505534167295 3424 1868434
SGTC_419 nsc-638432 893 µM -0.576921590929648 0.292200737004828 no 2372 0.28199621224898 3424 368090
SGTC_1795 st049545 62.3 µM -0.577603278332667 0.291963927866753 no 2373 0.28176599654931 3467 5291882
SGTC_1600 coumarin 106 71.1 µM -0.578321506543424 0.291714521661099 no 2374 0.281523538537122 3532 100336 A hepatotoxic, DNA x-linker.
SGTC_1181 1222-0449 220 µM -0.579429142200915 0.291330087688256 no 2375 0.281149822557374 3556 658318
SGTC_1458 k015-0034 6.33 µM -0.581114299096517 0.290745663747184 no 2376 0.280581711055831 3447 3598957
SGTC_2558 carylophyllene oxide 100 µM -0.581926578685301 0.290464155583554 no 2377 0.28030806841072 3547 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1004 4084-0029 199 µM -0.58299099113782 0.290095460091906 no 2378 0.279949682432998 3509 716894 YLR208W SEC13
SGTC_2068 5226020 147 µM -0.583684743357343 0.289855273519197 no 2379 0.279716216823348 3464 1810509
SGTC_1562 morin hydrate 59.1 µM -0.583902843723923 0.289779783445305 no 2380 0.279642839919635 3532 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1574 spiramycin 23.7 µM -0.585078622689397 0.289372975490661 no 2381 0.279247426093917 3476 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3051 9093778 49.47 µM -0.586483910020338 0.288887112196644 no 2382 0.278775185478742 3474 17217378
SGTC_2537 larixol 68.93 µM -0.587329018012655 0.288595109995369 no 2383 0.278491377956648 3514 6708759
SGTC_2442 5158906 48.48 µM -0.587529246484658 0.288525947317731 no 2384 0.27842415706764 3494 1893835
SGTC_1842 st055362 61.2 µM -0.58758491538428 0.288506719621159 no 2385 0.278405469257616 3474 676032
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.588369887243977 0.288235659462231 no 2386 0.278142022679615 3465 5106787 A p450 inhibitor.
SGTC_2475 5812728 15.03 µM -0.589086327858547 0.287988368857534 no 2387 0.277901682238785 3513 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_46 0329-0187a 2.197 µM -0.589924172444596 0.287699300901798 no 2388 0.277620743719493 3469 46494817
SGTC_191 3914-0123 66.505 µM -0.590106653366743 0.2876363606504 no 2389 0.277559574262051 3375 3144412
SGTC_101 0490-5701 117.494 µM -0.590535488385698 0.287488475009199 no 2390 0.277415850339885 3459 4661669
SGTC_1080 nisoldipine 24.4 µM -0.591488030595004 0.287160115333575 no 2391 0.277096736337714 3433 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1225 1216-0074 20.6 µM -0.592393493532198 0.286848149486692 no 2392 0.276793561137349 3449 4241466
SGTC_18 0111-0177 500 nM -0.592764814024252 0.286720262143962 no 2393 0.27666927928538 3559 721752
SGTC_62 0180-0423 3.232 µM -0.595280842461816 0.285854423950489 no 2394 0.275827879718572 3478 30102 YGL099W LSG1
SGTC_3174 9107204 49.47 µM -0.596083708073344 0.285578396553148 no 2395 0.27555965366596 3535 3938802
SGTC_212 3807-4682 38.772 µM -0.597181735717396 0.285201097151496 no 2396 0.275193025951747 3544 3125501 YBL034C STU1
SGTC_1144 3486-0183 12.5 µM -0.597198964370882 0.285195179011134 no 2397 0.275187275276928 3473 6744069
SGTC_3284 9108171 64.8615 µM -0.597200789316 0.285194552135545 no 2398 0.275186666140165 3459 8687505
SGTC_426 0988-0037 14.6 µM -0.597295740444527 0.285161936967663 no 2399 0.275154973925889 3547 5383008
SGTC_1339 1486-1321 22.7 µM -0.597311072650733 0.285156670609504 no 2400 0.275149856603231 3450 3469382
SGTC_3033 9090887 49.47 µM -0.598578438512011 0.284721511850149 no 2401 0.274727018927985 3468 19325384
SGTC_1321 1326-2144 215 µM -0.599895233263782 0.284269717364242 no 2402 0.274288029701354 3500 3513030
SGTC_215 1287-0124 461.5 µM -0.600995082713331 0.283892620029925 no 2403 0.273921630729742 3482 5560863
SGTC_1901 st060216 58.6 µM -0.602074580217024 0.283522733600678 no 2404 0.273562247145963 3536 688792
SGTC_476 mead acid 10 µM -0.603054911763745 0.283187026302557 no 2405 0.27323607994634 3531 5312531 An omega 9 fatty acid.
SGTC_2346 9031566 143.75 µM -0.604577470286428 0.282666015780079 no 2406 0.272729890071035 3448 4771086
SGTC_2405 ticlatone 3.52 µM -0.607616255881374 0.281627540665258 no 2407 0.271721008380904 3382 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3036 9090181 49.47 µM -0.607883836902671 0.281536185688383 no 2408 0.271632260122079 3537 25236586
SGTC_2192 5915882 198.485 µM -0.607922695115423 0.281522920274335 no 2409 0.271619373268011 3481 2876149
SGTC_793 0488-0545 106 µM -0.608957979717819 0.281169605960717 no 2410 0.271276145846945 3432 292548
SGTC_1408 3909-7976 48.8 µM -0.609246882252417 0.281071049660336 no 2411 0.27118040471954 3519 24152374
SGTC_542 3381-0244 89.3 µM -0.609403383273581 0.281017667823483 no 2412 0.271128547952272 3568 1112843
SGTC_3285 9112818 20.8695 µM -0.609495175972969 0.280986360001157 no 2413 0.271098134652007 3550 17017947 YPR165W RHO1
SGTC_667 1498-1044 59 µM -0.610074264771382 0.280788888507646 no 2414 0.270906306757671 3513 6739982
SGTC_1000 4048-0884 8.67 µM -0.610328621489646 0.280702173111042 no 2415 0.27082207043205 3538 13040088
SGTC_893 0958-0369 48.9 µM -0.610460717246888 0.280657144082282 no 2416 0.270778328913453 3522 6819948
SGTC_2748 diazoxide 86.69 µM -0.610733048659088 0.280564322312098 no 2417 0.270688161603866 3467 3019 A potassium channel activatior.
SGTC_1932 st074806 40.9 µM -0.611484739102036 0.280308192345791 no 2418 0.27043935920411 3643 17251235
SGTC_764 1951-2361 146 µM -0.61209252502 0.280101179043622 no 2419 0.270238271429297 3450 5438930
SGTC_2173 5763948 167 µM -0.612679079025858 0.279901467662953 no 2420 0.270044279216501 3538 2867177
SGTC_687 k029-0044 34.9 µM -0.613854642050129 0.279501417023636 no 2421 0.269655692718478 3557 5829338
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.615146953197175 0.279061956975559 no 2422 0.269228838182692 3504 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2073 5212005 126 µM -0.615175510264869 0.279052249727337 no 2423 0.269219409520149 3438 691789
SGTC_2015 5119600 184 µM -0.617644391865011 0.278213637627864 no 2424 0.268404887690434 3553 2828786
SGTC_3252 9135871 49.47 µM -0.617930806576685 0.278116429929702 no 2425 0.268310475376662 3567 17682838
SGTC_3138 9097216 49.47 µM -0.618615275637422 0.277884191731979 no 2426 0.268084918100728 3569 25237486
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.620051955299162 0.277397038937739 no 2427 0.267611790893288 3531 6312947
SGTC_655 k060-0012 42 µM -0.620885748011807 0.277114506103045 no 2428 0.267337399514617 3484 5994525
SGTC_1813 st051246 8.6015 µM -0.621679917619989 0.276845530663339 no 2429 0.267076179682297 3517 5291959
SGTC_2695 st077686 51.995 µM -0.621849394104704 0.276788147629879 no 2430 0.267020451833166 3516 2876092
SGTC_3023 9089636 49.47 µM -0.621971147323798 0.276746926810935 no 2431 0.266980420139749 3632 17249241
SGTC_458 nppb 133 µM -0.622291260100498 0.276638563651046 no 2432 0.266875183533517 3606 4549 A chloride channel blocker.
SGTC_3256 9138902 49.47 µM -0.622338572771103 0.27662254933931 no 2433 0.266859631340228 3548 17228773
SGTC_31 0508-1974 57.237 µM -0.623791019796365 0.276131148752333 no 2434 0.266382418995261 3527 6810525
SGTC_1087 pterostilbene 9.05 µM -0.624098678084969 0.276027114978986 no 2435 0.266281391006832 3578 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2887 9044784 58.44 µM -0.624169993816786 0.276003002515627 no 2436 0.266257975310575 3566 6465546
SGTC_364 0083-0097 67.7 µM -0.624248862576859 0.275976337512926 no 2437 0.266232080878504 3564 5207356
SGTC_1788 fluconazole 20 µM -0.624516825001811 0.275885750653959 no 2438 0.266144112161521 3542 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_7 0192-1582 4.227 µM -0.624686363321634 0.275828444403307 no 2439 0.266088462451482 3587 252616
SGTC_496 calpeptin 138 µM -0.624990860299436 0.275725534984685 no 2440 0.265988528350256 3517 73364 A calpain inhibitor.
SGTC_2429 5902844 64.44 µM -0.625061016840694 0.275701827181961 no 2441 0.265965506084968 3541 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1384 3089-0840 101 µM -0.625822008203937 0.275444731912128 no 2442 0.265715847351824 3541 1069836
SGTC_3311 9131146 2.8755 µM -0.627818041687903 0.274770947764528 no 2443 0.26506157289221 3517 4900406 YPR165W RHO1
SGTC_670 4204-0025 119 µM -0.63009038456508 0.274004882602188 no 2444 0.264317725185679 3542 719039
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.631814558033061 0.273424324576489 no 2445 0.263754029834903 3591 5282362
SGTC_2999 9069765 71.4286 µM -0.632577827844083 0.27316751349342 no 2446 0.263504684947906 3548 2097066
SGTC_2722 naftopidil 47.16 µM -0.633396655266436 0.272892142351777 no 2447 0.263237324331547 3546 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2297 7971671 152.32 µM -0.633494042404753 0.272859400281816 no 2448 0.263205535051949 3599 909016
SGTC_1364 1653-0028 37.6 µM -0.634133862232363 0.272644337941859 no 2449 0.2629967327228 3533 5718652
SGTC_2746 daunorubicin 9.88 µM -0.634509034762343 0.272518270515451 no 2450 0.262874336242568 3474 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_717 1532-0246 73.2 µM -0.636128841013191 0.271974307250053 no 2451 0.262346224366365 3544 9561992
SGTC_1819 st053448 58.6 µM -0.636685703711117 0.271787426459315 no 2452 0.262164793794264 3521 2857616
SGTC_776 4476-4378 112 µM -0.637542928224403 0.271499870458603 no 2453 0.261885628521225 3566 2892008
SGTC_2078 5212016 200 µM -0.637767299510915 0.271424630131479 no 2454 0.261812584546581 3519 1899708
SGTC_3279 9140807 49.47 µM -0.637839791702251 0.271400322930494 no 2455 0.261788986979059 3601 45595718
SGTC_1809 st050081 57.6 µM -0.637867635109374 0.271390987105751 no 2456 0.261779923717985 3639 5036894
SGTC_3301 9125354 19.7965 µM -0.63891594794975 0.271039606901401 no 2457 0.261438806306896 3558 41905162
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.639238080985986 0.270931677887858 no 2458 0.261334031184158 3619 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_111 0083-0039 52.457 µM -0.639496976622665 0.270844951785175 no 2459 0.261249839927136 3502 759313
SGTC_1883 5-benzylidenerhodanine 20 µM -0.639687993908475 0.270780972782322 no 2460 0.26118773122452 3566 1273210
SGTC_2312 7706453 155.7 µM -0.639790123572334 0.270746768742994 no 2461 0.261154527181202 3582 976098
SGTC_466 geldanamycin 89.2 µM -0.639907247418519 0.270707545687895 no 2462 0.26111645095186 3486 5288382 HSP90 inhibitor.
SGTC_1765 st044815 90.4 µM -0.640028262609608 0.270667022459009 no 2463 0.261077112668083 3551 645695
SGTC_3074 9116018 49.47 µM -0.640855491672513 0.270390097129697 no 2464 0.26080828778155 3610 17027303
SGTC_3163 9099914 49.47 µM -0.642096156059816 0.269975034759952 no 2465 0.2604053758024 3600 16268368
SGTC_468 gf-109203x 121 µM -0.642098057401265 0.26997439891387 no 2466 0.260404758578365 3500 2396 A protein kinase C inhibitor.
SGTC_624 k048-0052 28 µM -0.64364257816998 0.269458128416591 no 2467 0.259903616703236 3537 6835531
SGTC_800 3448-7362 155 µM -0.643902725885218 0.269371220332537 no 2468 0.259819257032155 3659 15991913
SGTC_1739 st037196 92.5 µM -0.644143512410382 0.269290792807106 no 2469 0.25974118832268 3597 612214
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.644239132365232 0.269258857166859 no 2470 0.259710189421202 3579 61125 An anti-inflammatory.
SGTC_2202 7226349 200 µM -0.644829604066747 0.269061690508507 no 2471 0.259518807523926 3543 844334
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.648566469911697 0.267815582060469 no 2472 0.258309317015525 3621 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2852 9023854 51.95 µM -0.649141426267652 0.26762411348627 no 2473 0.258123483746043 3641 19798528
SGTC_706 4262-0057 46.9 µM -0.649846649801754 0.267389358363734 no 2474 0.257895641149546 3571 883298
SGTC_2528 xanthyletin 44.79 µM -0.651159910539192 0.266952476545966 no 2475 0.257471633030976 3622 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2897 9048598 12.99 µM -0.652499578792495 0.266507181552621 no 2476 0.257039472246233 3572 6467404
SGTC_3325 9138760 55.175 µM -0.654315453514439 0.265904199673945 no 2477 0.256454295888479 3580 43844959
SGTC_2083 5306046 65.942 µM -0.655189038704921 0.265614362241161 no 2478 0.256173025385794 3625 539837
SGTC_1852 st056254 31.4 µM -0.656842871625614 0.265066093938049 no 2479 0.255640977343493 3563 442583
SGTC_2922 7999257 32.47 µM -0.65902926064308 0.264342159420495 no 2480 0.254938489545421 3597 2988377
SGTC_2465 5809242 33.21 µM -0.660382332019589 0.263894649176822 no 2481 0.254504253644955 3611 2731748
SGTC_1922 5578187 25 µM -0.661745495526394 0.263444191959212 no 2482 0.254067171103358 3648 1350412
SGTC_1331 1472-0049 76.2 µM -0.662403053897571 0.26322704229122 no 2483 0.253856473526222 3595 24051409
SGTC_2119 5528445 120.635 µM -0.662503331997767 0.263193934854985 no 2484 0.253824350063848 3622 791935
SGTC_543 3844-1095 191 µM -0.662636650740147 0.263149922140206 no 2485 0.253781645542971 3616 4230703
SGTC_3169 9102970 49.47 µM -0.664956489220785 0.262384672876612 no 2486 0.253039161603555 3679 17027839
SGTC_2461 5755302 26.15 µM -0.665752898417487 0.262122222957566 no 2487 0.25278452787914 3627 2788904
SGTC_1424 4048-1941 275 µM -0.665788187438906 0.262110596872234 no 2488 0.252773248139475 3673 X1424
SGTC_3216 9129716 49.47 µM -0.671042667671002 0.260382444994961 no 2489 0.251096674301812 3594 8056934
SGTC_1390 3413-2614 145 µM -0.672036267339145 0.260056319985831 no 2490 0.250780304055525 3646 3421432
SGTC_1058 3448-5425 97.3 µM -0.672382380084726 0.25994276634493 no 2491 0.250670148517085 3569 7279705
SGTC_2805 7950783 58.44 µM -0.67309178946562 0.259710101276507 no 2492 0.250444448529537 3627 1178958 YDL195W SEC31
SGTC_1071 trifluoperazine 6.31 µM -0.673938142832746 0.259432663348743 no 2493 0.25017532050078 3683 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2205 7238770 200 µM -0.674530195227656 0.259238677312218 no 2494 0.249987147691792 3646 279867
SGTC_3032 9089427 49.47 µM -0.677070734788735 0.258407121070952 no 2495 0.249180537958435 3611 17173707
SGTC_3258 9138477 49.47 µM -0.677436410783244 0.258287543771169 no 2496 0.249064551558386 3679 4970355
SGTC_861 0443-0273 110 µM -0.678633593455691 0.257896261674381 no 2497 0.248685025976142 3651 6149169
SGTC_1956 st077085 54 µM -0.678926036135619 0.257800727713159 no 2498 0.248592363914637 3649 24208685
SGTC_1057 3448-5381 134 µM -0.678964207848795 0.257788259291578 no 2499 0.248580270355889 3667 5497911
SGTC_1354 1498-1681 81 µM -0.679808404977166 0.257512590473055 no 2500 0.248312892030131 3688 5754243
SGTC_962 1254-0300 21.5 µM -0.681673739075466 0.256904017328679 no 2501 0.247722638213162 3606 7340576
SGTC_2790 5423970 71.43 µM -0.68366276713495 0.256255913930263 no 2502 0.247094069850684 3670 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1131 3454-3128 32.3 µM -0.685038423995435 0.255808170063949 no 2503 0.246659837322957 3705 710982
SGTC_3250 9135583 49.47 µM -0.687708110518972 0.25494041670217 no 2504 0.245818305763856 3669 7699353
SGTC_2592 piperlongumine 83.33 µM -0.688655541060811 0.254632835162219 no 2505 0.245520030142795 3638 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_796 1234-0020 70.7 µM -0.68872575770627 0.254610047199053 no 2506 0.245497931869829 3624 46495034
SGTC_1937 st074714 47.2 µM -0.689196603038977 0.254457267641425 no 2507 0.245349777115128 3627 17250970
SGTC_1985 st071382 65.5 µM -0.689667595331888 0.254304488473321 no 2508 0.245201624210046 3690 6123237
SGTC_1624 st003710 6.25 µM -0.689770988974546 0.254270956369608 no 2509 0.245169107679482 3671 24207033
SGTC_2404 5161160 200 µM -0.690209574064666 0.254128742445907 no 2510 0.245031201718673 3627 2831543
SGTC_1837 st055472 66.5 µM -0.690339615452627 0.254086583742956 no 2511 0.244990320337676 3719 676091
SGTC_2931 9014674 55.67 µM -0.691543043956186 0.253696612977465 no 2512 0.244612170193687 3663 2996810
SGTC_2026 5148700 152 µM -0.692952651208451 0.253240230043126 no 2513 0.244169633102637 3651 79838
SGTC_2471 5466956 24.79 µM -0.693196040876384 0.253161472466111 no 2514 0.244093266216731 3634 724419
SGTC_262 fenpropimorph 62.5 µM -0.696208726108148 0.252187676206997 no 2515 0.243149061849008 3628 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2614 arthonioic acid 13.39 µM -0.696809093159823 0.251993854697499 no 2516 0.242961137337168 3635 6710684
SGTC_900 1112-0045 141 µM -0.697179649679151 0.251874264083706 no 2517 0.242845186432157 3593 56211 YIL048W NEO1
SGTC_316 k060-0003 58.6 µM -0.697315336419495 0.251830481063932 no 2518 0.242802736161775 3672 6152314
SGTC_825 1988-2224 89.6 µM -0.700816491417464 0.250702128921319 no 2519 0.241708772439176 3686 1180859
SGTC_1152 3909-8331 15.9 µM -0.700844354407353 0.250693159988777 no 2520 0.241700077169983 3660 16001939
SGTC_2118 5526350 200 µM -0.701672303002871 0.250426725772945 no 2521 0.241441774793576 3696 743594
SGTC_3316 9136639 10.545 µM -0.701697825719213 0.250418514936939 no 2522 0.241433814631233 3694 4903665
SGTC_2752 diclazuril 33.15 µM -0.702021060624907 0.250314540359018 no 2523 0.241333014722853 3724 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_327 1273-0057 3.96 µM -0.702108110496822 0.250286543045285 no 2524 0.241305872370639 3603 3108138
SGTC_258 haloperidol 50.781 µM -0.702959664704121 0.250012750500577 no 2525 0.241040443292616 3695 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3351 9150312 21.596 µM -0.703000331422706 0.249999679274407 no 2526 0.241027771467164 3654 4904905
SGTC_550 4123-0385 25.7 µM -0.704772194301045 0.249430513745246 no 2527 0.240476007581715 3698 5731123
SGTC_545 4218-0007 221 µM -0.705491166169155 0.249199759037117 no 2528 0.240252313739023 3635 2840508
SGTC_590 k048-0076 22.4 µM -0.706489624606661 0.248879491250692 no 2529 0.239941851353057 3676 6832814
SGTC_1909 st060837 51.5 µM -0.707112920611925 0.248679672544732 no 2530 0.23974815359927 3683 678937
SGTC_742 0kpi-0133 140 µM -0.708069749720289 0.248373094806797 no 2531 0.239450971968201 3696 2728852
SGTC_2070 5230947 200 µM -0.708776806162672 0.248146676268971 no 2532 0.239231496561822 3758 2835538
SGTC_616 4092-0450 108 µM -0.710587251978459 0.247567424901787 no 2533 0.238670022539225 3728 787165
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.711005788230627 0.247433617278693 no 2534 0.238540324480093 3697 16486 A toxic proline analog.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.711479230754261 0.247282302513487 no 2535 0.238393658313656 3749 5024745
SGTC_3302 9125395 16.351 µM -0.714057904484788 0.246459013871344 no 2536 0.237595687276257 3659 17599668
SGTC_268 camptothecin 39.6153 µM -0.714710311427713 0.246250954102623 no 2537 0.237394032411844 3697 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1127 asiatic acid 681.4 nM -0.715052434111482 0.246141885058202 no 2538 0.237288322023119 3680 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3188 9110789 49.47 µM -0.716196308026634 0.245777405145247 no 2539 0.236935071228222 3714 849217
SGTC_368 fentichlor 4.58 µM -0.717485118506886 0.245367090552742 no 2540 0.236537407759084 3694 7329 A pesticide.
SGTC_2403 6032726 181.2 µM -0.717649904003385 0.245314654863837 no 2541 0.236486589561705 3712 2881040
SGTC_1879 gemcitabine 100 µM -0.719492111164273 0.244728864279099 no 2542 0.235918880582072 3710 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1904 st060225 78 µM -0.72063727501672 0.244365101561261 no 2543 0.235566356877258 3682 66595
SGTC_3124 9127567 49.47 µM -0.721217566541534 0.244180882539215 no 2544 0.235387832725988 3664 17592030
SGTC_879 0831-1030 162 µM -0.721777431226402 0.244003219208271 no 2545 0.235215663604111 3743 1549252
SGTC_345 1362-0200 395 µM -0.722664819404495 0.243721764902312 no 2546 0.234942917240838 3715 1419823
SGTC_1052 3253-3998 198 µM -0.723245378990969 0.243537722789506 no 2547 0.234764571886217 3693 5450317
SGTC_1192 1488-0095 21.4 µM -0.725058649098059 0.242963385088873 no 2548 0.234208025503147 3743 915875
SGTC_1659 st012954 42.1 µM -0.72554150349872 0.242810568743151 no 2549 0.234059946413261 3696 24207262
SGTC_3141 9094609 49.47 µM -0.72638575466774 0.24254350064766 no 2550 0.233801160818005 3678 25236309 YDL196W YDL196W
SGTC_1750 st081859 2.357 µM -0.730160003606882 0.241351512846758 no 2551 0.232646193668939 3726 5291695
SGTC_1304 1165-0502 251 µM -0.731489760359671 0.240932306964353 no 2552 0.232240028360549 3741 767425
SGTC_614 0462-0418 107 µM -0.731608170697844 0.240894997312347 no 2553 0.232203879856849 3584 5188303
SGTC_3308 9128332 17.569 µM -0.73227055273489 0.240686346795449 no 2554 0.2320017245337 3707 17332805 YDL196W YDL196W
SGTC_1299 1079-1439 3.74 µM -0.732754955315528 0.240533822146061 no 2555 0.231853949609463 3703 323161
SGTC_234 nsc-17383 10.7 µM -0.733763157680608 0.240216536617913 no 2556 0.231546549184749 3735 408974
SGTC_1782 st039423 80.636 µM -0.733812525071507 0.240201006351923 no 2557 0.231531502927513 3740 2068169
SGTC_974 1326-0144 138 µM -0.735955902244866 0.239527258839999 no 2558 0.230878767451091 3781 5411856
SGTC_2775 cyproheptadine 69.59 µM -0.737707749575539 0.23897735169625 no 2559 0.230346030932051 3732 2913 A selective serotonin reuptake inhibitor.
SGTC_1908 st060353 56.5 µM -0.738045258003363 0.238871486724291 no 2560 0.230243473692378 3756 4227716
SGTC_2301 7769476 200 µM -0.739022321561663 0.238565159604441 no 2561 0.229946721603138 3773 977820
SGTC_2049 5262831 67.185 µM -0.739788980770933 0.238324948688618 no 2562 0.229714023135914 3777 763417
SGTC_1987 st072290 61.9 µM -0.739913469005129 0.238285956337204 no 2563 0.229676250581847 3744 54697379
SGTC_2507 purpurin 79.67 µM -0.74018707889081 0.238200268208205 no 2564 0.229593243362976 3746 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2706 st078239 82.5 µM -0.741958373866787 0.237645949243084 no 2565 0.229056278211336 3746 15434492
SGTC_2259 7964009 200 µM -0.743532829076182 0.237153825186616 no 2566 0.228579576716092 3753 313134
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.745025916284725 0.236687651859714 no 2567 0.228128026430795 3805 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1527 coumarin 137 µM -0.74613896205578 0.236340463685981 no 2568 0.227791737625097 3809 323 A hepatotoxic, DNA x-linker.
SGTC_3053 9095903 49.47 µM -0.74733882866319 0.235966508080845 no 2569 0.227429529991654 3811 17174018
SGTC_1015 4130-4525 82 µM -0.748064685196474 0.235740442898429 no 2570 0.227210570907678 3763 1363237
SGTC_1327 1436-0082 2.18 µM -0.748904988662605 0.235478882892569 no 2571 0.226957236654873 3765 15992205
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.749258942225723 0.235368756247171 no 2572 0.226850574618634 3739 6708760
SGTC_1604 st002052 72.4 µM -0.749526466351803 0.235285539521189 no 2573 0.226769976403375 3763 6254834 YHR062C RPP1
SGTC_438 sphingosine 6.67 µM -0.749973993991207 0.235146366772361 no 2574 0.22663518383595 3709 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.749985173851354 0.235142890626548 no 2575 0.226631817110023 3700 140250 A respiratory chain inhibitor.
SGTC_3052 9092717 49.47 µM -0.750203234058767 0.235075094999901 no 2576 0.226566155658796 3726 25237534
SGTC_1298 1079-1278 263 µM -0.750240415386475 0.235063536281943 no 2577 0.226554960832144 3785 2840950
SGTC_2091 4-phenylthiadiazole 200 µM -0.750514493542856 0.234978342123938 no 2578 0.226472449007562 3759 270010
SGTC_2124 5246320 200 µM -0.751176430342256 0.234772656778998 no 2579 0.226273241489211 3773 579342
SGTC_392 N-ethylmaleimide 8.33 µM -0.751756273371517 0.234592562457205 no 2580 0.22609882116381 3723 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2356 9061756 188.97 µM -0.752302513839594 0.234422974723799 no 2581 0.225934578227045 3758 20104043
SGTC_1042 0350-0096 82 µM -0.752945944400724 0.234223300056016 no 2582 0.225741198847362 3766 3122515
SGTC_1045 1348-1485 165 µM -0.753357724376464 0.234095562531557 no 2583 0.225617489877705 3790 6810614
SGTC_9 0092-0002 10.449 µM -0.753647155360466 0.234005801760502 no 2584 0.225530560557832 3741 759368
SGTC_139 0099-0334 718.624 µM -0.756443711648949 0.23313949294525 no 2585 0.224691604302858 3802 97690
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.756834471758763 0.233018586385195 no 2586 0.224574518860091 3689 17037758
SGTC_794 k038-0031 316 µM -0.75710173871894 0.232935910363603 no 2587 0.22449445623684 3776 6624242
SGTC_449 xestospongin c 11.1929 µM -0.757483863461255 0.232817732688344 no 2588 0.224380014896901 3776 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2903 5923464 63.88 µM -0.757641519781524 0.232768984870539 no 2589 0.224332808551209 3786 2876576
SGTC_3289 9119912 71.43 µM -0.757829574882874 0.232710845074929 no 2590 0.224276507404741 3767 17014829
SGTC_1545 lovastatin 49.4 µM -0.757949924424756 0.232673641610814 no 2591 0.224240480594583 3841 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_474 dl-dihydrosphingosine 5 µM -0.758313682780023 0.232561213663362 no 2592 0.224131608980381 3769 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2355 9061122 103.12 µM -0.758941643943127 0.232367198814119 no 2593 0.223943733046958 3793 5302957
SGTC_555 4296-0685 37 µM -0.759528805932153 0.232185870756625 no 2594 0.223768144555627 3735 2908540 YHR072W ERG7
SGTC_1108 betulinic acid 729.144 nM -0.761002325042626 0.231731163820443 no 2595 0.22332783926215 3787 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2295 7971645 200 µM -0.761660894157157 0.231528099346032 no 2596 0.223131210396242 3809 2978226 YKL099C UTP11
SGTC_2071 5230951 39.92 µM -0.761792012505064 0.231487681905322 no 2597 0.223092074183081 3803 1799272
SGTC_65 0798-0905 34.986 µM -0.762615407791489 0.231233958924613 no 2598 0.222846396464029 3840 3602145
SGTC_524 r073-0010 27.8 µM -0.763431622518119 0.230982601773878 no 2599 0.222603013428897 3724 2772106
SGTC_228 caffeine 993.056 µM -0.763560545544951 0.230942913277139 no 2600 0.222564584371888 3764 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_701 4424-0219 185 µM -0.76577665724814 0.230261286659184 no 2601 0.221904602874077 3785 2911779
SGTC_1735 st034310 56.75 µM -0.766496018986278 0.230040269138192 no 2602 0.22169060986264 3917 871153
SGTC_3099 9120367 49.47 µM -0.767410384684268 0.229759509803777 no 2603 0.221418778075818 3797 24824940
SGTC_371 0195-0006 7.36 µM -0.76801719135821 0.229573293569173 no 2604 0.221238485766147 3655 3928593
SGTC_2942 9052777 62.25 µM -0.768525925558254 0.22941723890202 no 2605 0.221087397146694 3866 6469503
SGTC_2825 7998094 58.44 µM -0.768779225469899 0.229339561105832 no 2606 0.221012191803393 3777 2987815
SGTC_2218 6965428 192.983 µM -0.768925652284469 0.229294664096077 no 2607 0.22096872401468 3718 675684
SGTC_283 0987-0079 11.7 µM -0.769454076059177 0.229132681156068 no 2608 0.220811898548926 3811 411556
SGTC_1269 0831-0796 3.05 µM -0.771657114945156 0.228458053984898 no 2609 0.220158768399256 3785 927758
SGTC_428 3448-4153 16.5 µM -0.77168388306895 0.228449863764882 no 2610 0.220150839330813 3768 3834874
SGTC_996 3970-0799 1.8 µM -0.77438688486644 0.227623678474876 no 2611 0.219351018530369 3842 6615648 YGL040C HEM2
SGTC_2299 7976368 114.88 µM -0.774667346092631 0.22753805060882 no 2612 0.219268125513455 3837 2979718
SGTC_22 0964-0034 14.468 µM -0.775126096565408 0.227398028204308 no 2613 0.219132576211139 3803 138402
SGTC_864 0469-0573 172 µM -0.775332177861303 0.227335142714019 no 2614 0.21907170002356 3769 689425
SGTC_921 1561-0023 372 µM -0.776141716396977 0.227088207750451 no 2615 0.218832657388205 3776 24050882
SGTC_1067 clotrimazole 1.36 µM -0.779397215547261 0.226096705380931 no 2616 0.217872881782674 3816 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1141 3253-0389 52.6 µM -0.781884311410265 0.225340881184175 no 2617 0.217141282925795 3757 5402031
SGTC_2441 5730946 39.09 µM -0.782181614344374 0.225250627161856 no 2618 0.217053923993765 3885 1774275
SGTC_1515 3460-0031 42.1 µM -0.782911524589401 0.225029130819555 no 2619 0.216839534705593 3754 2876596
SGTC_87 0100-0052 35.5 µM -0.784378032596429 0.224584482085544 no 2620 0.216409162163282 3880 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_425 3825-7017 13.1 µM -0.784739208088047 0.224475049358181 no 2621 0.216303244787447 3912 3397440
SGTC_1184 1269-1718 139 µM -0.784848862066829 0.224441831237909 no 2622 0.216271093889242 3866 5403821
SGTC_3294 9122953 26.2835 µM -0.785122314599212 0.224359004819139 no 2623 0.216190928783534 3803 16459826
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.785469073658982 0.22425399943856 no 2624 0.216089297948067 3819 616764
SGTC_546 peri-Naphthalide 147 µM -0.786807909407936 0.223848835913425 no 2625 0.215697161349215 3762 223824 A penicillin ester.
SGTC_1412 3909-8563 178 µM -0.786953481249119 0.223804807504925 no 2626 0.215654549150347 3892 23767530
SGTC_613 3914-0030 117 µM -0.788080405264817 0.223464134341096 no 2627 0.215324837967166 3563 1145395
SGTC_1467 k284-1082 293 µM -0.789171391111914 0.223134606643343 no 2628 0.215005920272917 3779 3334705
SGTC_2565 isoliquiritigenin 100 µM -0.789737777529115 0.222963641160381 no 2629 0.214840462046836 3890 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2098 5376439 882.5 nM -0.7904102865905 0.222760739157403 no 2630 0.214644098345804 3845 2844116
SGTC_1697 st025554 27.742 µM -0.791080777198305 0.222558550933023 no 2631 0.214448427887983 3787 1269519
SGTC_560 2332-1943 155 µM -0.792512944100952 0.222127027827388 no 2632 0.214030823646426 3794 21177716
SGTC_3273 9137859 49.47 µM -0.792514396247697 0.222126590526691 no 2633 0.214030400456633 3890 2377234
SGTC_2949 9072542 2.23 µM -0.79277718515185 0.222047462145214 no 2634 0.21395382559429 3899 16457352
SGTC_1646 st011709 75.6 µM -0.793095889373694 0.221951518695033 no 2635 0.213860978800365 3758 5757843
SGTC_850 0388-0143 75.9 µM -0.793146921096288 0.221936158187134 no 2636 0.21384611411729 3780 67273
SGTC_3066 9117245 49.47 µM -0.796486793454879 0.220932180021339 no 2637 0.212874574306581 3897 17176980
SGTC_2624 nerol 100 µM -0.797404355967777 0.220656813216991 no 2638 0.212608115131941 3755 637566 A natural product oil.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.798787625049739 0.220242056507558 no 2639 0.212206783655845 3863 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3255 9139072 49.47 µM -0.799625760880682 0.219990969130979 no 2640 0.211963828723155 3831 17646060
SGTC_2594 a-mangostin 100 µM -0.803319043495565 0.218886499871384 no 2641 0.210895176854854 3873 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1368 1852-0141 284 µM -0.803929891755494 0.218704134775311 no 2642 0.21071873279231 3831 2838987
SGTC_1993 st073995 70.8 µM -0.806941136111939 0.217806424841185 no 2643 0.209850198707693 3830 3098394
SGTC_760 0568-0725 82.9 µM -0.807784815741364 0.217555289387088 no 2644 0.209607233852131 3887 3916171
SGTC_1031 k035-0009 16 µM -0.809557749653473 0.217028090702575 no 2645 0.209097199627539 3927 5180959
SGTC_282 k297-0036 65.7 µM -0.810123212444149 0.216860100401204 no 2646 0.208934682214329 3833 5061378
SGTC_2705 st078069 42.8 µM -0.810874581790085 0.216636996472459 no 2647 0.20871884929991 3889 1530061
SGTC_1389 3405-0187 19 µM -0.814450204770392 0.215577108429176 no 2648 0.207693543792325 3814 799890
SGTC_1481 3346-2004 36 µM -0.81521647329271 0.215350362602432 no 2649 0.207474205021572 3885 2770522
SGTC_748 act1.228 77.9 µM -0.819916067328163 0.213962740109488 no 2650 0.20613197827222 3809 4421505 YNR035C ARC35
SGTC_1224 0823-0416 294 µM -0.820830946402249 0.213693215490763 no 2651 0.205871284350072 3945 3598164
SGTC_2694 st077685 81.9 µM -0.821159811435995 0.213596379749056 no 2652 0.205777622384101 3852 2838096
SGTC_909 3448-9333 149 µM -0.821230541183229 0.213575556408127 no 2653 0.205757481597457 3789 3344074
SGTC_3079 9117512 49.47 µM -0.822128559511427 0.21331127628719 no 2654 0.205501866370973 3882 7185044
SGTC_205 1486-1330 71.903 µM -0.823065987224485 0.213035601785741 no 2655 0.205235234761287 3852 4118834
SGTC_1280 0880-0253 10.1 µM -0.825195512222832 0.212410133673708 no 2656 0.204630300442456 3848 6836607
SGTC_301 4119-0100 24.5 µM -0.82531076260136 0.21237631383057 no 2657 0.20459759154735 3886 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3140 9094243 49.47 µM -0.825799796674662 0.212232843402459 no 2658 0.204458834732098 3879 19291112
SGTC_3267 9137951 49.47 µM -0.82592009040829 0.212197560898156 no 2659 0.204424711594521 3876 16643986
SGTC_475 α-linolenic acid 10 µM -0.826005399848943 0.212172541467623 no 2660 0.20440051433551 3897 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_502 l-744,832 89.3 µM -0.827002787044146 0.211880157150922 no 2661 0.204117740898727 3852 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2924 9010168 62.78 µM -0.828177669124549 0.211536042712754 no 2662 0.203784944222931 3973 2993929
SGTC_324 1315-0088 19.6 µM -0.830878785915116 0.210746147242156 no 2663 0.203021054509602 3846 6787421
SGTC_2330 7979373 200 µM -0.831279830608757 0.210629016259117 no 2664 0.20290778297096 3828 1863007
SGTC_3330 9141424 71.43 µM -0.832516996331382 0.210267924619337 no 2665 0.202558594329257 3956 27261020
SGTC_1128 3448-9350 235 µM -0.833153321301739 0.210082342067751 no 2666 0.202379132299302 3939 619386
SGTC_408 cantharidin 100 µM -0.834630410132822 0.209651924007461 no 2667 0.201962917263004 3856 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2110 5483698 200 µM -0.835875602606403 0.209289482851487 no 2668 0.201612444480843 3869 2848765 YHR062C RPP1
SGTC_131 0141-0277 33.849 µM -0.836801956917812 0.209020086077906 no 2669 0.201351948621519 3843 1547771
SGTC_357 1325-0123 420 µM -0.838232169064331 0.20860456171149 no 2670 0.200950161623545 3922 1098503
SGTC_2423 st077119 87.2 µM -0.842761417917852 0.207291880738662 no 2671 0.199680944977936 3821 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1431 4049-0260 9.09 µM -0.84452741260565 0.206781381117423 no 2672 0.199187375886121 3866 3854841
SGTC_811 0416-0114 265 µM -0.84698561693154 0.206072023504305 no 2673 0.198501569214964 3977 6612453
SGTC_229 benomyl 22.8748 µM -0.84892150908669 0.205514405161994 no 2674 0.197962484698097 3916 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1627 st003713 25.6 µM -0.848960911087916 0.205503065039551 no 2675 0.197951521681449 3969 16195070 YER133W GLC7
SGTC_2522 biochanin a 4.94 µM -0.849580400820148 0.205324821179915 no 2676 0.197779206152742 3891 5280373 A possible chelator.
SGTC_1565 sinapyl alcohol 95.1 µM -0.850100435637948 0.205175264100633 no 2677 0.197634624725079 3944 5280507 A phenol propionate derived from cinnamic acid.
SGTC_816 0325-0417 81.3 µM -0.850437851772405 0.20507826105656 no 2678 0.197540849598475 3936 68101
SGTC_181 1447-1644 8.07 µM -0.850655604092089 0.205015674380972 no 2679 0.19748034587751 3909 534600
SGTC_125 0133-0007 11.75 µM -0.85091618519793 0.204940792721009 no 2680 0.197407956663808 3985 26541
SGTC_3352 9151559 45.5865 µM -0.851742171977494 0.204703541242678 no 2681 0.197178604296721 3895 17159339
SGTC_2366 9070441 60.58 µM -0.851983504334855 0.204634253240206 no 2682 0.197111623807037 3909 6837235
SGTC_1981 st071826 47 µM -0.852617345190813 0.20445234009694 no 2683 0.196935770289411 3929 11838600
SGTC_3019 9081971 49.47 µM -0.853631030794841 0.204161611160294 no 2684 0.196654729702602 3926 16451803
SGTC_175 3793-3120 23.7 µM -0.856117331243864 0.203449574006333 no 2685 0.19596644154364 3916 5322297
SGTC_1178 0988-0033 191 µM -0.856310716059404 0.203394253815649 no 2686 0.195912967717353 3973 5392207
SGTC_1140 3229-1848 2.98 µM -0.857752773248307 0.202982018041613 no 2687 0.195514496322098 3940 2849525
SGTC_105 0111-0055 734.78 µM -0.857830569696076 0.202959792841396 no 2688 0.195493013493148 3930 5179370
SGTC_2904 7225135 42.03 µM -0.85827958522371 0.202831544694368 no 2689 0.195369049682122 3998 4446116
SGTC_1967 st070177 51.4 µM -0.859024890220034 0.202618777032393 no 2690 0.195163391978532 3963 5729214
SGTC_2106 5357045 167.29 µM -0.863430066652955 0.201363925878527 no 2691 0.193950527154214 3951 668842
SGTC_1653 st012112 65 µM -0.863443672853709 0.201360057269214 no 2692 0.193946788126981 3894 720429
SGTC_858 0438-0351 2.77 µM -0.863789756485157 0.201261671350695 no 2693 0.193851698013416 3913 2799119
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.864802838007693 0.200973834546051 no 2694 0.193573506607125 3979 165506
SGTC_3198 9112019 49.47 µM -0.865432544139892 0.200795046913097 no 2695 0.193400712559931 3972 45595555
SGTC_34 0469-0683 81.75 µM -0.865624597601585 0.2007405376485 no 2696 0.193348031005025 3898 3690923
SGTC_346 4513-0042 7.16 µM -0.866090886254512 0.200608230988359 no 2697 0.193220161337957 3921 2827372
SGTC_3077 9117319 49.47 µM -0.866312938029652 0.200545243512169 no 2698 0.193159286545869 3882 17154678
SGTC_1132 3456-3614 2.5 µM -0.866785247925253 0.200411307015305 no 2699 0.193029843222516 4021 3125502
SGTC_13 0199-0087 65 µM -0.869838912878416 0.199546653562837 no 2700 0.192194221346848 3961 4589825
SGTC_1664 st014217 9.02 µM -0.87055848646812 0.199343231703683 no 2701 0.191997635862187 3953 3982782
SGTC_454 lyso-paf C-16 6.67 µM -0.871141524044741 0.199178499882216 no 2702 0.191838441917673 3865 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1768 st044301 37.178 µM -0.872538348279317 0.198784173928789 no 2703 0.191457378601633 3942 3931349
SGTC_379 3970-0972 5.9 µM -0.873831741172238 0.198419466819438 no 2704 0.191104945936471 3926 2898042 YBL034C STU1
SGTC_1172 0370-0043 85 µM -0.873877329323989 0.198406619377304 no 2705 0.191092531023051 3984 376585
SGTC_2902 5787006 60.46 µM -0.874083335882303 0.19834856982075 no 2706 0.191036435912081 3901 591003
SGTC_548 1436-0017 110 µM -0.87465566765771 0.198187349116573 no 2707 0.190880644298959 4012 9677137
SGTC_2751 anetholtrithion 17.25 µM -0.875324789641036 0.197998963824427 no 2708 0.190698604763256 3956 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1605 st000082 49.1 µM -0.875362572578782 0.197988329603966 no 2709 0.190688328817453 3937 1114022
SGTC_2345 9052315 157.45 µM -0.875521495723857 0.19794360356746 no 2710 0.190645109705229 3985 6469265
SGTC_2164 5685496 200 µM -0.876872382280258 0.197563667519499 no 2711 0.190277979240167 3845 759046
SGTC_664 1222-0054 14.9 µM -0.877342515565577 0.197431546289276 no 2712 0.190150313050211 3901 6813991
SGTC_1964 st076914 61 µM -0.877576851497805 0.197365710983186 no 2713 0.190086698042562 3975 24208661
SGTC_1815 st051655 58.2 µM -0.878001148650142 0.197246540975758 no 2714 0.189971547683843 3880 5984156
SGTC_2830 7992007 71.43 µM -0.878750142998662 0.197036281325099 no 2715 0.189768382164712 3834 1952075
SGTC_296 1222-0039 74.9 µM -0.878913185437552 0.196990529610677 no 2716 0.189724174444126 3941 5984176
SGTC_885 0865-0106 16.8 µM -0.879028253597356 0.196958243940211 no 2717 0.189692978398297 3859 2793380
SGTC_2801 7907800 81.82 µM -0.881801174743177 0.196181190429396 no 2718 0.188942168139016 3989 6620925
SGTC_3057 9095946 49.47 µM -0.88215262928072 0.196082835515396 no 2719 0.188847137419537 3967 24540043
SGTC_1756 st041558 35.5 µM -0.883968913678388 0.195575023281447 no 2720 0.188356497043858 4028 3955792
SGTC_3274 9138298 49.47 µM -0.886031014847955 0.19499945249584 no 2721 0.18780040730214 3907 17015756
SGTC_1560 lithocholic acid 53.1 µM -0.887669886106569 0.194542748353452 no 2722 0.187359174510194 3811 9903 A bile acid which acts as a detergent.
SGTC_2238 6671620 73.2395 µM -0.887792586904177 0.194508581543934 no 2723 0.18732616561935 3900 729941
SGTC_1065 prochlorperazine maleate 2.48 µM -0.888878971429967 0.194206230279881 no 2724 0.187034064003479 3986 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1147 3809-1045 12.3 µM -0.889064413927826 0.194154648464215 no 2725 0.186984231324127 3926 325925
SGTC_912 3474-0017 2.18 µM -0.889248708046789 0.194103394344786 no 2726 0.186934715379788 4008 3360550
SGTC_1402 3909-7673 35.9 µM -0.889489980480256 0.194036306421212 no 2727 0.186869902828625 3953 5328014
SGTC_1714 st033236 13.627 µM -0.891355298054216 0.193518115414695 no 2728 0.186369295610906 3988 2916566
SGTC_1502 4534-4282 27.7 µM -0.893265842228517 0.192988236301513 no 2729 0.185857412782806 3924 3278949
SGTC_488 nitrendipine 139 µM -0.893513663153413 0.192919569482268 no 2730 0.185791079269482 4007 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1743 st037606 46.3785 µM -0.893740535734276 0.192856720166142 no 2731 0.185730365816023 3932 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1939 st074455 53.6 µM -0.894780881600836 0.192568678838997 no 2732 0.185452116132972 3978 1644229
SGTC_1216 1165-0504 9.65 µM -0.897108666967229 0.191925136286791 no 2733 0.184830467203697 3995 6304004
SGTC_1746 st038117 42 µM -0.897122085785231 0.191921430323324 no 2734 0.184826887387284 4036 2898218
SGTC_2760 etidronate 98.04 µM -0.89727724659231 0.191878581721442 no 2735 0.184785497363092 3936 3305 A chelator and antioxidant.
SGTC_1690 st023502 41.2 µM -0.897448009646347 0.191831431233755 no 2736 0.184739952011398 3960 24207482
SGTC_2178 5812956 200 µM -0.8984751938015 0.191547958487804 no 2737 0.184466132150901 3918 5403383
SGTC_1260 0700-1617 7.75 µM -0.900379561594135 0.191023088088044 no 2738 0.18395914685594 3999 2853078
SGTC_2905 7799065 20.05 µM -0.90050746987109 0.190987866418394 no 2739 0.183925125936096 3879 1296806
SGTC_2094 5332512 191.667 µM -0.901122873017947 0.190818460627692 no 2740 0.183761496382443 4014 755774
SGTC_1607 st000305 50.6 µM -0.901650913612126 0.190673177180474 no 2741 0.18362116797226 3983 5457690
SGTC_2087 5276107 200 µM -0.901663141569319 0.190669813622853 no 2742 0.183617919146351 3932 144405
SGTC_2438 5259590 200 µM -0.903538082023086 0.190154502669527 no 2743 0.183120193164992 3993 1201127
SGTC_3280 9140961 49.47 µM -0.904391548978829 0.189920218455193 no 2744 0.182893908883225 4015 4901226
SGTC_2789 5281112 71.43 µM -0.908722394710528 0.188734100194911 no 2745 0.18174833995058 4010 765948
SGTC_1662 st014054 52 µM -0.911748385310737 0.187908067296208 no 2746 0.180950593387595 4012 2838777
SGTC_1715 st032160 10.2275 µM -0.912261473528868 0.187768226485871 no 2747 0.180815545050777 3939 5289825
SGTC_949 1165-0505 146 µM -0.915879979152319 0.186783838638064 no 2748 0.179864924351336 4017 6244267
SGTC_517 1365-0151 113 µM -0.916769151105052 0.186542435716108 no 2749 0.179631810551268 4054 768657
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.918151564391514 0.186167505704766 no 2750 0.179269761135798 3933 6708514
SGTC_1753 st043925 64 µM -0.919503655308152 0.18580125167701 no 2751 0.178916097292423 4048 670181
SGTC_939 1165-0479 45.3 µM -0.92163581295887 0.185224602178274 no 2752 0.178359285744985 3985 1377347
SGTC_223 busulfan 5 mM -0.92268435262363 0.184941429082639 no 2753 0.178085861245569 4008 2478 A DNA alkylator.
SGTC_29 0299-0004 12.984 µM -0.923436706581506 0.18473841101625 no 2754 0.177889835110109 3891 16871 A napthoquinone isolated from Swertia calycina.
SGTC_456 gingerol 170 µM -0.923770898248528 0.184648275915599 no 2755 0.177802804999656 4005 442793 A herb.
SGTC_674 0498-0004 451 µM -0.923782762344229 0.184645076543587 no 2756 0.177799715848576 3991 4231473
SGTC_3243 9134147 49.47 µM -0.924341121058296 0.184494543813669 no 2757 0.177654369741806 4049 24282180
SGTC_2109 5483026 200 µM -0.925601924320168 0.184154913895155 no 2758 0.177326446486074 4012 759335
SGTC_952 1185-0122 232 µM -0.928797550819318 0.183295833997043 no 2759 0.176497006991121 3943 678600
SGTC_2459 5811157 9.22 µM -0.929188695620627 0.183190854514642 no 2760 0.176395652398971 3973 2870684 YBR192W RIM2
SGTC_2888 9058547 12.99 µM -0.930739712518503 0.182774945863872 no 2761 0.175994110934978 3915 16476514
SGTC_1401 3807-4679 7.6 µM -0.930744167773969 0.18277375202683 no 2762 0.175992958351886 3941 3291456
SGTC_170 4197-0004 226 µM -0.931144990338222 0.182666366921561 no 2763 0.175889284347021 4046 218692
SGTC_2062 5245942 200 µM -0.93362930459276 0.182001668843263 no 2764 0.17524757178331 4068 1376160
SGTC_1091 telmisartan 47.6 µM -0.93430708220755 0.181820586961591 no 2765 0.175072756061032 4065 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1838 st055369 84.5 µM -0.934746903667691 0.181703140153926 no 2766 0.174959374362726 4012 676036
SGTC_507 nimesulide 162 µM -0.93491454261584 0.181658387533209 no 2767 0.174916170937715 4071 4495 A COX2 inhibitor.
SGTC_627 1391-0720 175 µM -0.937315122189843 0.181018289435357 no 2768 0.174298243260331 3987 997839
SGTC_2489 cantharidin 73.42 µM -0.937748529666525 0.180902875087408 no 2769 0.174186828831289 3969 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_586 0957-0265 8.15 µM -0.937780012304909 0.180894493207752 no 2770 0.174178737471625 3907 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_480 am 92016 50 µM -0.942512201716647 0.179637372600366 no 2771 0.172965233546979 3991 2129 K+ channel blocker.
SGTC_1870 st057514 26.5 µM -0.943180324334721 0.179460327086128 no 2772 0.172794337810292 4010 5393161
SGTC_2529 gangaleoidin 93.61 µM -0.946536896033743 0.178572531306499 no 2773 0.171937406362725 4049 4565183
SGTC_1026 k007-1105 30.6 µM -0.950939216821698 0.177412341184176 no 2774 0.170817616225863 4012 7066794
SGTC_2663 amphotericin b 100 µM -0.950978819634299 0.17740192588051 no 2775 0.170807563939769 4008 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3172 9105863 49.47 µM -0.952519057917954 0.176997151881237 no 2776 0.170416902676817 4055 2348785
SGTC_3120 9124077 49.47 µM -0.952909666791252 0.176894592862414 no 2777 0.170317920888841 4129 18774327 YGL155W CDC43
SGTC_2943 9068529 45.32 µM -0.953164543769311 0.176827692124701 no 2778 0.170253353943727 4023 3270634
SGTC_1281 0884-0031 11.8 µM -0.955886861242024 0.176114129433318 no 2779 0.169564698826918 4048 1548255
SGTC_2857 9024691 58.44 µM -0.956379161368737 0.175985284629002 no 2780 0.169440354463305 4146 16478292
SGTC_2317 5986382 200 µM -0.960612767033074 0.174879729974658 no 2781 0.168373453465682 4074 877883
SGTC_540 1187-0821 17.3 µM -0.960631123254603 0.17487494608771 no 2782 0.168368836984477 3988 847520
SGTC_2090 5301565 104.445 µM -0.961292236562258 0.174702706116284 no 2783 0.168202625158668 4044 2056344
SGTC_708 3448-5400 146 µM -0.961411504857189 0.174671644597001 no 2784 0.168172650920299 3989 3462195
SGTC_2882 9058044 58.44 µM -0.96207135263822 0.174499861165912 no 2785 0.168006881572482 4076 18076804
SGTC_2028 5153890 36.43 µM -0.96220175884627 0.174465924181348 no 2786 0.167974132902602 4018 2830968 YPR165W RHO1
SGTC_761 k216-0224 480 µM -0.963368473631615 0.174162484231649 no 2787 0.167681320811739 4078 1340404
SGTC_2656 pseudo-anisatin 100 µM -0.963981279105838 0.174003239821669 no 2788 0.167527655892375 4074 6708809 A neurotoxin.
SGTC_2141 5621638 7.665 µM -0.964180793652489 0.173951413700134 no 2789 0.167477645916975 4072 2856238
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.965175260118674 0.173693236388073 no 2790 0.167228518122753 4062 115019
SGTC_714 4296-0578 26.1 µM -0.965736411476497 0.173547661343554 no 2791 0.167088047321117 4080 1589775
SGTC_876 0720-0963 56.8 µM -0.966541058028042 0.173339053805693 no 2792 0.166886756133928 4093 765861
SGTC_1253 0550-0034 176 µM -0.966799417735318 0.173272106986363 no 2793 0.166822157799968 4081 5969915
SGTC_3234 9132280 49.47 µM -0.967766847868604 0.173021570318379 no 2794 0.166580412100882 4083 17612295
SGTC_2883 9059145 45.46 µM -0.969671116838949 0.172529093841181 no 2795 0.166105225915996 4025 16476510
SGTC_1436 4092-1007 8.32 µM -0.969959339802908 0.172454632424281 no 2796 0.166033379908838 4039 2881121
SGTC_2875 9039966 71.43 µM -0.971748317909257 0.171992914589697 no 2797 0.165587886377794 4071 6463691
SGTC_3008 9078912 71.4286 µM -0.973117425360102 0.17164009487896 no 2798 0.165247472240108 4041 16648731
SGTC_567 1080-0542 68.4 µM -0.973886451693275 0.171442119338203 no 2799 0.165056460734376 3928 5950415
SGTC_2698 st077697 67.5 µM -0.974685969751639 0.171236448915486 no 2800 0.164858027285388 4038 3154499
SGTC_832 4083-0019 164 µM -0.975543026420927 0.171016152361769 no 2801 0.164645484913692 4134 1990758
SGTC_2136 5328288 199.296 µM -0.975731039206604 0.170967850096996 no 2802 0.164598883185493 4062 262395
SGTC_3229 9132204 49.47 µM -0.977109613517201 0.170613947956326 no 2803 0.164257444447457 4110 17682924
SGTC_2821 7996764 71.43 µM -0.97731934137178 0.170560148583222 no 2804 0.164205540328054 4112 2987135
SGTC_1880 MG-132 525 µM -0.977420259742448 0.170534264881768 no 2805 0.164180568518217 4013 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_247 mechlorethamine 29.705 µM -0.977518503660856 0.170509069544194 no 2806 0.164156260855947 3942 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1790 st045711 43.5 µM -0.979491079181298 0.170003693261107 no 2807 0.16366869713812 4066 585119
SGTC_1911 st060208 74.3 µM -0.979997524031516 0.169874096524191 no 2808 0.163543670420954 4118 688783
SGTC_1810 st050138 53 µM -0.981987717112711 0.169365429696504 no 2809 0.163052949715227 4076 3444541
SGTC_360 0957-0399 1.01 µM -0.984607405094608 0.168697364302864 no 2810 0.162408475438712 4088 6752301 YPR165W RHO1
SGTC_837 0091-0265 12.5 µM -0.985676993932788 0.16842508836918 no 2811 0.162145821201718 4018 759367
SGTC_896 0964-0007 44.5 µM -0.986799064247905 0.168139756585498 no 2812 0.161870576784196 4028 6756758
SGTC_1609 st001574 46.4 µM -0.987182507371172 0.168042321999004 no 2813 0.161776587821128 4059 3960012
SGTC_1293 1000-1278 195 µM -0.988623923334405 0.16767637696 no 2814 0.161423588441148 4133 678847
SGTC_650 1328-0195 38 µM -0.989798022151261 0.16737867767118 no 2815 0.161136425883262 4066 2780821
SGTC_985 1493-0307 8.71 µM -0.990869919677725 0.167107189694196 no 2816 0.160874551083779 4087 3278274
SGTC_1063 disulfiram 1.84 µM -0.99147733922534 0.166953469838505 no 2817 0.160726276089491 4083 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.993899360442572 0.166341435342412 no 2818 0.160135932886613 4116 4174840
SGTC_1613 st002381 52.1 µM -0.994721372656814 0.166134046064237 no 2819 0.15993589832332 4066 551167
SGTC_2969 9091408 28.7 µM -0.995079954845334 0.166043630048235 no 2820 0.159848689484201 4026 4286311
SGTC_347 4534-1311 26.2 µM -0.995872361571114 0.16584393854607 no 2821 0.15965608286268 4083 2862016
SGTC_2961 9083290 32.55 µM -0.995991086982411 0.165814032369695 no 2822 0.15962723791581 4022 17741490
SGTC_329 k048-0121 21.3 µM -0.996406006742853 0.165709544102487 no 2823 0.159526457822658 4117 6832902
SGTC_2673 kobusone 100 µM -0.996431896956011 0.165703025642423 no 2824 0.15952017071502 4141 6710676 An epoxy ketone and protein crosslinker.
SGTC_2242 6630449 61.2675 µM -1.00049906187746 0.164681081727286 no 2825 0.158534525700335 4147 691249 YDR170C SEC7
SGTC_2779 methotrexate 400 µM -1.00288237431661 0.164084135835254 no 2826 0.157958808884615 4097 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2397 5161689 200 µM -1.00350106351468 0.163929403135467 no 2827 0.157809582024708 4167 2259942
SGTC_1942 st076330 65.2 µM -1.00914747600028 0.162521625601882 no 2828 0.156451956004769 4164 24208414
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.00939007137664 0.162461317896709 no 2829 0.156393799096329 4024 5355888
SGTC_435 c-PAF 6.7 µM -1.00945272186228 0.162445745741205 no 2830 0.156378782333157 4095 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2582 agaric acid 100 µM -1.01027929449323 0.16224038708995 no 2831 0.156180749155366 3836 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1926 methyl fluorone black 53.6 µM -1.01055771356519 0.162171253060351 no 2832 0.156114081752426 3819 72721 Reacts with homocysteine.
SGTC_977 1348-1378 135 µM -1.01179195569781 0.161865010368051 no 2833 0.155818768519951 4082 X977
SGTC_1278 0874-0585 172 µM -1.01332881286019 0.161484209252335 no 2834 0.155451564719001 4164 766306
SGTC_1493 4348-0038 111 µM -1.01427944180804 0.161248955893961 no 2835 0.155224715428286 4079 800424
SGTC_2373 9071805 200 µM -1.01717971645964 0.160532603486665 no 2836 0.154533971683635 4110 10149009
SGTC_422 cantharidin 155 µM -1.01725460536699 0.160514133900765 no 2837 0.154516162720621 4030 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2772 vinpocetine 57.06 µM -1.01810038913493 0.160305637623411 no 2838 0.154315125220759 4142 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2170 morpholine 200 µM -1.01835921478763 0.160241869248398 no 2839 0.154253638564396 4154 121171 Reacts with secondary amines.
SGTC_1865 st057639 52.2 µM -1.01874721444529 0.160146306587878 no 2840 0.154161495667533 4085 688818
SGTC_1925 st057770 10.1 µM -1.02292735325182 0.159119119707845 no 2841 0.153171097700081 4101 5989122
SGTC_2161 5662504 8.5105 µM -1.02482054482128 0.158655328269077 no 2842 0.152723935278788 4083 2859334
SGTC_2325 6158266 200 µM -1.03008190667085 0.157371066355262 no 2843 0.15148577897627 4143 3623240
SGTC_2982 9019404 25.97 µM -1.030257331833 0.157328364338964 no 2844 0.151444611469684 4060 22333232
SGTC_2171 5739187 198.077 µM -1.03402934202801 0.156412024008247 no 2845 0.150561223113761 4063 2262761
SGTC_2153 5569715 200 µM -1.03505450286274 0.156163588749713 no 2846 0.150321729256959 4155 2054701
SGTC_2683 piperine 63.03 µM -1.03594514576132 0.155947963450847 no 2847 0.150113867113943 4105 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_325 2810-4341 181 µM -1.03605684620141 0.155920934548813 no 2848 0.15008781150444 4128 774970
SGTC_991 3996-0057 64.7 µM -1.03736803888381 0.155603887385188 no 2849 0.149782183841142 4201 715343
SGTC_1931 st074438 57.1 µM -1.0394536761208 0.155100455813723 no 2850 0.149296895785744 4089 2787313
SGTC_2733 amorolfine 100 µM -1.04043738139209 0.154863382459641 no 2851 0.149068371051681 4246 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2287 7945887 168.79 µM -1.04146941782232 0.154614918704247 no 2852 0.148828869780025 4151 1245853
SGTC_129 0088-0017 176.636 µM -1.04239487980254 0.154392337015527 no 2853 0.148614319692499 3990 182446
SGTC_2033 5192550 145 µM -1.0437208688732 0.15407379446271 no 2854 0.148307275853017 4143 182073
SGTC_1802 st050112 57.9 µM -1.04392389467989 0.154025059952712 no 2855 0.148260301020397 4124 4662563
SGTC_3113 9123498 49.47 µM -1.04426910125773 0.153942219649658 no 2856 0.148180452149609 4226 8897275
SGTC_2370 9071495 200 µM -1.04511496446186 0.153739359860903 no 2857 0.147984919299406 4144 21791103
SGTC_1575 cyproterone acetate 48 µM -1.04894403919852 0.152823263719371 no 2858 0.147101937483699 4145 9880 An androgen receptor antagonist and liver toxin.
SGTC_2526 patulin 37.61 µM -1.05053831472003 0.152442907060308 no 2859 0.146735342408414 4171 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1736 st036774 51 µM -1.05124054481857 0.152275570945385 no 2860 0.146574063003008 4195 1272247
SGTC_108 0509-0257 621.132 µM -1.05419635318515 0.151572561501465 no 2861 0.145896514669558 4103 536624
SGTC_2718 lomofungin 53.02 µM -1.0553927099364 0.151288634349788 no 2862 0.145622877809631 4135 5351222 A RNA synthesis inhibitor.
SGTC_3002 9075603 71.4286 µM -1.06189861140708 0.14975080736053 no 2863 0.14414085777438 4095 20105405
SGTC_1637 st007924 17.4 µM -1.06407537685326 0.149238612607773 no 2864 0.143647277192874 4080 683336
SGTC_1816 st051957 91.6 µM -1.0651911221913 0.148976530789584 no 2865 0.143394725129029 4147 674121
SGTC_577 r071-0003 38.6 µM -1.06594515007641 0.148799588428972 no 2866 0.143224218684495 4155 4568517 YMR134W ERG29
SGTC_2681 menadione 3.18 µM -1.06699263876316 0.148554014880454 no 2867 0.142987580015774 4184 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2134 5324836 1.464 µM -1.07036448045029 0.147765360319524 no 2868 0.142227640404717 4121 699272
SGTC_1633 st005664 67.9 µM -1.07178460450806 0.147434041992697 no 2869 0.141908394823782 4157 2063822
SGTC_1135 dihydrocapsaicin 536.708 nM -1.07228902431128 0.147316479545092 no 2870 0.141795117515627 4074 107982 A Capsaicinoid.
SGTC_2387 9077560 195.08 µM -1.07637527936819 0.146366434074013 no 2871 0.140879726802136 4160 5303272
SGTC_621 3584-0052 32.1 µM -1.07671170265362 0.14628840008197 no 2872 0.140804541281425 4180 2273927
SGTC_1530 rhein 70.4 µM -1.07786060614704 0.146022120474114 no 2873 0.140547983982082 4242 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1854 st056233 32.9 µM -1.07881109675141 0.14580207300938 no 2874 0.140335973515184 4100 5393174
SGTC_920 mycophenolic acid 780.421 nM -1.07910881118535 0.145733195195699 no 2875 0.140269611891823 4166 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1965 Pectolinarigenin 58.4 µM -1.0791158324231 0.145731571059149 no 2876 0.140268047089844 4138 5320438 An anti-inflammatory.
SGTC_3038 9091290 49.47 µM -1.07996431308443 0.145535392042757 no 2877 0.140079036058503 4204 25236843
SGTC_3210 9128157 49.47 µM -1.08115348118981 0.145260740959273 no 2878 0.139814423428731 4187 17590849
SGTC_975 1335-0046 28.5 µM -1.08223501341288 0.145011252537424 no 2879 0.139574057060778 4189 16486740
SGTC_1520 flindersine 88 µM -1.08366333162469 0.144682209584952 no 2880 0.139257049703772 4257 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2720 fluspirilene 36.88 µM -1.08463201961789 0.144459338466761 no 2881 0.139042333761901 4174 3396 An atypical antipsychotic.
SGTC_1105 epirubicin 18.1 µM -1.08614795854273 0.144111022983885 no 2882 0.138706768637855 4217 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2010 4012422 159 µM -1.0862564424938 0.144086118486714 no 2883 0.138682776022192 4143 952393
SGTC_2233 sulbentine 40.3845 µM -1.08638546860432 0.1440565019357 no 2884 0.138654243925632 4179 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2273 7815444 169.05 µM -1.08698954847952 0.143917896525748 no 2885 0.138520714344897 4140 2824616
SGTC_1391 3442-0225 151 µM -1.08780918069514 0.143729976762657 no 2886 0.138339677874485 4152 5227075
SGTC_753 1322-0200 289 µM -1.08919323878415 0.143413025240682 no 2887 0.13803433993948 4254 5403907
SGTC_781 4335-2806 94.4 µM -1.092604791459 0.142633790654571 no 2888 0.137283679034689 4248 845254
SGTC_1323 1348-1351 11.2 µM -1.0945264152717 0.142196134274032 no 2889 0.136862084313659 4137 6989654
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.09460778529685 0.142177622050289 no 2890 0.136844251684784 4223 688798
SGTC_43 0570-0105 72.5 µM -1.09597632918401 0.141866513577586 no 2891 0.136544566741265 4173 1114046 YDL195W SEC31
SGTC_2972 9093619 59.92 µM -1.09646681292306 0.141755125139693 no 2892 0.136437269522507 4144 25236256
SGTC_1525 8-methoxypsoralen 92.5 µM -1.09699675059915 0.141634843336129 no 2893 0.13632140627719 4247 4114 Related to psoralen; DNA damaging agent.
SGTC_2378 9074213 121.43 µM -1.09916433267413 0.141143579576722 no 2894 0.135848196571213 4155 657714
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.10004634753998 0.14094400963982 no 2895 0.135655964291279 4228 688664
SGTC_2734 clemastine 41.6 µM -1.10340913814477 0.140184881244372 no 2896 0.134924765034826 4255 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_789 1309-1135 70.6 µM -1.10382489355979 0.140091220406852 no 2897 0.134834552051843 4176 3092424
SGTC_1461 k072-0203 53.8 µM -1.10813336057082 0.139123117763061 no 2898 0.133902112652039 4108 5418714
SGTC_1857 st056007 79.3 µM -1.11304585032728 0.138024860495668 no 2899 0.132844369054577 4177 619834
SGTC_442 cape 100 µM -1.1154778865793 0.137483338189006 no 2900 0.132322844728443 4210 5281787
SGTC_1376 2910-0861 41.3 µM -1.11598629945973 0.137370317461965 no 2901 0.132213999571694 4133 1112859
SGTC_2936 9038235 15.59 µM -1.11664893962174 0.137223107102053 no 2902 0.132072228858291 4144 4749415
SGTC_1539 benzyladenosine 56 µM -1.11701401826979 0.137142048262921 no 2903 0.131994165717506 4199 92208 A nucleotide analog.
SGTC_2822 7994718 71.43 µM -1.1191982622058 0.136657761378017 no 2904 0.131527783331232 4180 1018011
SGTC_751 0833-0568 350 µM -1.11992407682735 0.136497094137377 no 2905 0.131373058616145 4237 6954252
SGTC_1469 k284-2957 126 µM -1.12355098285643 0.135696173848781 no 2906 0.130601780294978 4209 23884841
SGTC_1154 4088-0362 150 µM -1.12444924096039 0.135498312195693 no 2907 0.130411246268031 4208 6618304
SGTC_747 3448-8087 38.7 µM -1.12478189640366 0.135425087502179 no 2908 0.130340733864654 4275 5168703
SGTC_2690 usnic acid 100 µM -1.12485391942542 0.135409237241703 no 2909 0.130325470742252 4243 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2018 5133068 143 µM -1.12525332408651 0.135321362478637 no 2910 0.130240851327101 4166 785362
SGTC_157 1348-1695 65.819 µM -1.12590005922816 0.135179154365635 no 2911 0.130103912148699 4158 5380510
SGTC_2858 9025781 8.96 µM -1.12693809808093 0.134951118257807 no 2912 0.129884327016809 4110 4894980 YPL153C RAD53
SGTC_1597 7-benzyloxygramine 47.5 µM -1.12730460379864 0.134870667440277 no 2913 0.129806858290728 4141 260807
SGTC_2715 st079500 56.4 µM -1.1279331695892 0.134732769040544 no 2914 0.129674072133257 4195 28246688
SGTC_424 splitomicin 100 mM -1.12838867402116 0.134632898323429 no 2915 0.129577904448596 4276 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2414 st077232 92.9 µM -1.12858756874725 0.134589305996562 no 2916 0.12953592860009 4162 729801
SGTC_998 3996-0085 177 µM -1.13177990201819 0.133890958669904 no 2917 0.128863489662657 4259 715391
SGTC_2796 7949634 45.45 µM -1.13389096548477 0.133430517655327 no 2918 0.128420143632531 4197 2971588
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.13454521132648 0.133288042373935 no 2919 0.128282960149573 4272 91467 include heat shock
SGTC_2626 ethyl orsellinate 100 µM -1.1345605694368 0.133284699092275 no 2920 0.128279741055325 4195 75653 A natural product.
SGTC_573 3702-0553 84.7 µM -1.13571876693942 0.133032739223788 no 2921 0.128037141867598 4186 1222756
SGTC_452 diindolylmethane 8 µM -1.13607084440764 0.132956211618251 no 2922 0.127963457976963 4226 3071 Inhibits expression of several cancer promoting factors.
SGTC_100 0086-0128 49.5915 µM -1.13643315753542 0.132877490836125 no 2923 0.127887662698951 4250 93297
SGTC_709 3807-1509 243 µM -1.13652898833137 0.132856674780153 no 2924 0.127867620280572 4304 1886677 YPL242C IQG1
SGTC_2027 5150920 200 µM -1.14590110593049 0.130831734850332 no 2925 0.125918036800087 4185 786715
SGTC_207 4185-0010 4.486 µM -1.14653627680942 0.1306952758131 no 2926 0.125786662974308 4304 3761753
SGTC_1568 digitonin 820 nM -1.14948817179959 0.130062387078303 no 2927 0.125177370648974 4234 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1074 carmofur 3.8 µM -1.15213604057115 0.129496489274839 no 2928 0.124632587584848 4280 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_707 0865-0008 204 µM -1.1525296069496 0.129412522812559 no 2929 0.124551755357326 4258 723043
SGTC_3344 9148862 3.898 µM -1.15284947651141 0.12934430719016 no 2930 0.124486086278569 4267 4905352
SGTC_2478 5763493 32.33 µM -1.15322743841423 0.129263734875797 no 2931 0.124408522074661 4181 1365576 YLR208W SEC13
SGTC_3309 9129340 25.759 µM -1.15513889351349 0.128856791869688 no 2932 0.124016776654626 4263 17158987
SGTC_2662 daunorubicin 22.37 µM -1.1556392389974 0.128750416740139 no 2933 0.123914375462876 4119 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1156 4092-0367 4.88 µM -1.15749852060782 0.128355661143498 no 2934 0.123534371686803 4268 1357585
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.1611428132256 0.127584358410894 no 2935 0.122791913162783 4209 2333 A French combination drug.
SGTC_2399 5884133 200 µM -1.16443674457375 0.126889986266249 no 2936 0.122123531969074 4235 722445
SGTC_2674 ligustilide 100 µM -1.16498273356018 0.126775144550606 no 2937 0.122012991036018 4308 5319022 A signalling regulator.
SGTC_2649 anisomycin 9.56 µM -1.16500993006593 0.126769426010472 no 2938 0.122007486669221 4294 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1013 4112-3890 241 µM -1.16872737279752 0.12598945837316 no 2939 0.121256744915103 4201 705171
SGTC_2504 purpurogallin 52.29 µM -1.17113685577341 0.125485708453238 no 2940 0.120771885758203 4149 5281571 An antioxidant.
SGTC_2007 4011539 71.82 µM -1.17193426617581 0.125319304096351 no 2941 0.120611724179651 4201 45595301
SGTC_54 0159-0055 9 µM -1.17215025125843 0.125274258651062 no 2942 0.120568368865504 4266 3319099
SGTC_1820 st053765 18.6 µM -1.17483559630682 0.12471515198141 no 2943 0.120030247959457 4310 3690829
SGTC_1211 1056-0033 32.3 µM -1.17571140810972 0.124533179863633 no 2944 0.119855109158571 4319 6741922
SGTC_1844 rapamycin 4 nM -1.17713906107687 0.124236946815874 no 2945 0.119570003333818 4153 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_533 1222-0222 6.71 µM -1.17715021729903 0.124234633880978 no 2946 0.11956777729409 4289 3982874
SGTC_592 k241-0073 46.5 µM -1.17787071820359 0.124085321678789 no 2947 0.119424075152637 4299 4230158
SGTC_1591 genipin 88.4 µM -1.1799316668153 0.123658916695233 no 2948 0.119013696953333 4307 442424 A DNA cross-linking agent.
SGTC_1949 st076024 69.1 µM -1.18010198384266 0.123623724493971 no 2949 0.118979827850414 4188 2921930
SGTC_2937 9044753 11.33 µM -1.18108538770782 0.123420663255358 no 2950 0.118784402074872 4211 6465530 YGL099W LSG1
SGTC_2328 6201408 200 µM -1.18210885593994 0.123209577448314 no 2951 0.118581255457566 4269 2890418
SGTC_1960 st011366 51.8 µM -1.1860407148288 0.122401002348426 no 2952 0.117803110544967 4284 3972846
SGTC_1447 4239-0816 81.9 µM -1.18624830760504 0.122358415254686 no 2953 0.117762127009137 4273 1341554
SGTC_214 4373-3496 70 µM -1.18785001546009 0.122030178903563 no 2954 0.117446252692302 4364 3779166
SGTC_853 0419-0306 21 µM -1.19008552977026 0.121573091830971 no 2955 0.117006388525361 4290 762713
SGTC_483 fpl-64176 144 µM -1.19009450997811 0.12157125811216 no 2956 0.117004623919484 4387 3423
SGTC_654 1124-0271 80.9 µM -1.19036557452273 0.121515917077638 no 2957 0.116951368761902 4252 5403748
SGTC_744 1594-0068 283 µM -1.19154306370905 0.121275724272602 no 2958 0.116720230738011 4254 668392
SGTC_1303 1160-0052 261 µM -1.19459319696571 0.120655089115599 no 2959 0.116123004255901 4221 3562476
SGTC_1959 st077091 55.8 µM -1.1985355993257 0.119856214423478 no 2960 0.11535428631184 4285 821356 YKL052C ASK1
SGTC_430 0958-0115 16.4 µM -1.20002226287345 0.119555932545714 no 2961 0.115065347139888 4231 6833180
SGTC_2571 chrysanthemic acid 100 µM -1.20260895209992 0.119034729108989 no 2962 0.114563840903902 4273 2743 An insecticide.
SGTC_2276 7947513 42.08 µM -1.20295528135121 0.118965067665766 no 2963 0.114496813002282 4230 2105100
SGTC_1873 rapamycin 2 nM -1.20351054040359 0.118853441699298 no 2964 0.114389407488499 4237 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3173 9105693 49.47 µM -1.20600787900073 0.118352306290724 no 2965 0.113907226233975 4290 17096658
SGTC_1719 st032227 49.2 µM -1.21126613849987 0.11730203120158 no 2966 0.112896710966584 4296 3125804
SGTC_311 1315-0136 58 µM -1.2124604098546 0.117064412370715 no 2967 0.112668094282968 4301 6759207
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.2125606326607 0.117044487010263 no 2968 0.112648923903467 4277 688803
SGTC_983 1491-0821 12.2 µM -1.21405775191332 0.116747129807694 no 2969 0.112362835760608 4285 46495113
SGTC_523 1934-0222 13.7 µM -1.21471845826076 0.116616071069716 no 2970 0.112236745030671 4248 1361595
SGTC_3348 9149464 3.537 µM -1.21814322795137 0.115938400437293 no 2971 0.111584774600749 4238 1951442
SGTC_3012 9080433 71.4286 µM -1.21954177667866 0.115662470489443 no 2972 0.111319314821607 4299 17688859
SGTC_762 1165-0429 115 µM -1.21979001123293 0.115613543259097 no 2973 0.111272244480407 4304 5967793
SGTC_2893 9048488 25.97 µM -1.22139970579622 0.115296627954484 no 2974 0.110967359271018 4345 6467338
SGTC_1488 4013-0813 75.9 µM -1.22149500407804 0.115277885088823 no 2975 0.110949328019861 4247 2910057
SGTC_3035 9091303 49.47 µM -1.22901217169057 0.113806257540912 no 2976 0.10953362125141 4394 25237002
SGTC_839 0122-0028 230 µM -1.23000471515865 0.113612953568624 no 2977 0.10934766958355 4322 759448
SGTC_890 0929-0006 47.2 µM -1.23186253726707 0.113251760602671 no 2978 0.10900021883783 4306 1378169
SGTC_2795 7780010 54.55 µM -1.23187382064051 0.113249569424016 no 2979 0.108998111043359 4283 953673
SGTC_3106 9121286 49.47 µM -1.23386158945856 0.112864025823262 no 2980 0.108627242282738 4274 15943471
SGTC_246 cycloheximide 667 µM -1.23577641613147 0.112493516856294 no 2981 0.108270841835873 4212 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2596 sinensetin 100 µM -1.23718259264979 0.112221982913674 no 2982 0.108009651254176 4331 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1244 0416-0015 52.5 µM -1.23770203331785 0.112121797030165 no 2983 0.107913282470528 4271 96201
SGTC_352 k048-0007 5.11 µM -1.23841344607501 0.111984688753593 no 2984 0.107781398729272 4258 6811911
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.23992258304894 0.111694234647113 no 2985 0.107502015042233 4317 5377381
SGTC_1970 st070122 35.8 µM -1.24056162896823 0.111571404055498 no 2986 0.107383867104578 4341 102928
SGTC_2425 5628681 7.85 µM -1.24085604153547 0.111514847744071 no 2987 0.107329467094702 4388 5714958
SGTC_3102 9121669 49.47 µM -1.24172694652809 0.111347668018142 no 2988 0.107168662152767 4360 41905072
SGTC_3281 9140613 49.47 µM -1.24439167122434 0.110837259446511 no 2989 0.106677723373995 4326 16013766
SGTC_1307 1187-1599 12.2 µM -1.24605253178521 0.110519982924486 no 2990 0.106372555007309 4317 1538471
SGTC_232 clozapine 119 µM -1.24672984242797 0.110390782390635 no 2991 0.106248286326613 4325 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2157 5649910 96.377 µM -1.24895602193647 0.109966890084734 no 2992 0.105840579741948 4304 2858091
SGTC_2056 5235370 200 µM -1.25164244865573 0.109456917710396 no 2993 0.105350089796767 4239 5511916
SGTC_2044 5102272 200 µM -1.25225976964769 0.10933997021718 no 2994 0.105237611552252 4327 592666
SGTC_178 4092-0806 87.505 µM -1.25268188304818 0.109260055235479 no 2995 0.105160750914317 4221 2169044
SGTC_1425 4048-4433 7.33 µM -1.25284120795833 0.109229902576451 no 2996 0.105131750755694 4383 23734946
SGTC_2353 9059630 146.67 µM -1.25379517633036 0.109049486615429 no 2997 0.104958231468092 4365 4779114
SGTC_146 3448-8650 53.125 µM -1.25397855260752 0.109014830768579 no 2998 0.10492490054677 4293 2891488 YIL048W NEO1
SGTC_3022 9087993 49.47 µM -1.25651772425945 0.108535772257444 no 2999 0.104464161942864 4400 17173644
SGTC_3156 9099931 49.47 µM -1.25786188937633 0.108282786234537 no 3000 0.104220854272982 4373 18111053
SGTC_2187 6125751 200 µM -1.26311594313617 0.107297989866892 no 3001 0.103273757580052 4350 874498
SGTC_2197 6588183 93.1375 µM -1.26358473583445 0.107210436245518 no 3002 0.10318955756543 4322 884136
SGTC_2260 7964312 200 µM -1.26367298799806 0.107193959677624 no 3003 0.103173712141794 4392 231951
SGTC_1732 st034308 51.822 µM -1.26439597264029 0.107059048101288 no 3004 0.103043968842658 4206 830119
SGTC_2455 5377712 9.75 µM -1.26702800298252 0.106568936141475 no 3005 0.1025726385799 4327 2243908
SGTC_3312 9133330 71.43 µM -1.2721627168649 0.105617464136614 no 3006 0.101657655702661 4370 17617324
SGTC_409 arachidonic acid 100 µM -1.2726896636091 0.105520168565983 no 3007 0.101564093474388 4330 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2655 perillic acid 100 µM -1.27377785246306 0.105319450299851 no 3008 0.101371078188455 4375 5702197 An apoptosis inducer.
SGTC_1084 voriconazole 435 nM -1.27493624785541 0.105106085999734 no 3009 0.101165903942154 4361 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_678 1218-2179 85.9 µM -1.28313029408465 0.10360575665913 no 3010 0.0997232159818579 4386 6820081 YOR116C RPO31
SGTC_1170 0310-0127 64.8 µM -1.28500051903663 0.103265507640703 no 3011 0.0993960513272834 4360 774975
SGTC_2053 5265679 138 µM -1.28661224294537 0.102972939046711 no 3012 0.0991147371400609 4257 764595
SGTC_503 tyrphostin 8 294 µM -1.28722030922264 0.102862716249259 no 3013 0.0990087552097555 4380 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1351 1496-0003 46.5 µM -1.29228590993216 0.101947816587676 no 3014 0.0981290748234893 4374 3891978
SGTC_3000 9075062 71.4286 µM -1.29259532735756 0.101892125142216 no 3015 0.0980755282745274 4333 17057871
SGTC_1998 st075797 76.8 µM -1.29368233608486 0.101696652073982 no 3016 0.0978875845845219 4339 24208315
SGTC_3206 9114350 49.47 µM -1.29404465078915 0.101631558964923 no 3017 0.0978249991056879 4224 17087243
SGTC_2203 7227154 166.4 µM -1.2947908120805 0.101497599935061 no 3018 0.0976962011893783 4385 896304
SGTC_1160 4092-0570 10.5 µM -1.29497150518248 0.101465179285173 no 3019 0.0976650297309187 4357 4994975
SGTC_2488 5268135 45.7 µM -1.29562419722685 0.101348133605623 no 3020 0.0975524942414398 4400 1270356 YLR208W SEC13
SGTC_3130 9127414 49.47 µM -1.29660947594764 0.101171632329474 no 3021 0.0973827951813325 4371 1494646
SGTC_1310 1188-0297 994 nM -1.29833011397834 0.100863937300867 no 3022 0.097086961305706 4237 1588352
SGTC_3275 9138069 49.47 µM -1.29858425765464 0.100818547667644 no 3023 0.0970433216749946 4437 17617007
SGTC_1104 tacrolimus 29.8 µM -1.30536401332837 0.0996131878230347 no 3024 0.0958844630944975 4437 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1385 3091-4834 14.1 µM -1.30611302938801 0.0994806704010752 no 3025 0.0957570613590704 4355 4072814
SGTC_2013 4024628 200 µM -1.30684584071907 0.0993511446964789 no 3026 0.0956325364832878 4406 5230760
SGTC_1473 k844-0725 134 µM -1.30966721315942 0.0988536132015385 no 3027 0.0951542198819324 4411 54682906
SGTC_976 1348-1067 47.6 µM -1.31080109283526 0.09865417496969 no 3028 0.0949624866267664 4395 5310671 YGL099W LSG1
SGTC_2200 6600604 21.907 µM -1.31668341716297 0.0976242580077173 no 3029 0.0939723822053899 4408 2904777
SGTC_990 3985-0011 41.3 µM -1.31775682255272 0.0974371726789796 no 3030 0.0937925330343539 4356 5399565 YGL099W LSG1
SGTC_1194 1488-0194 225 µM -1.31844825275559 0.0973168016803733 no 3031 0.09367681846593 4345 1391452
SGTC_516 3992-2719 87.3 µM -1.318669432666 0.0972783195380731 no 3032 0.0936398250776322 4279 5350887 YDR037W KRS1
SGTC_1772 st048439 82.2 µM -1.32025867174754 0.0970021429393011 no 3033 0.0933743344689561 4427 2927068 YDL195W SEC31
SGTC_2306 7482397 179.52 µM -1.3228290830212 0.0965566780647861 no 3034 0.0929461116110473 4400 891448
SGTC_2971 9092186 9.93 µM -1.32344847148751 0.0964495600646008 no 3035 0.0928431407533224 4344 25236400
SGTC_1476 4112-3294 3.34 µM -1.32690331633345 0.0958536753299628 no 3036 0.0922703336045273 4385 704369
SGTC_33 0986-0033 35.816 µM -1.32761536849497 0.0957311992801501 no 3037 0.0921526024149693 4343 2848082
SGTC_2808 7946468 45.46 µM -1.32815487327692 0.0956384788167146 no 3038 0.0920634744026262 4363 2970879
SGTC_2154 5570129 200 µM -1.32924169969526 0.0954518951387584 no 3039 0.0918841208303222 4442 673366
SGTC_2400 5203494 178.7 µM -1.33128393167897 0.0951020147962701 no 3040 0.0915478016604095 4303 6777674
SGTC_3158 9100007 49.47 µM -1.33207081397918 0.0949674565218409 no 3041 0.0914184599453114 4395 19297233
SGTC_1610 st001799 48.1 µM -1.33326417585359 0.094763657235346 no 3042 0.0912225627722393 4346 621897
SGTC_2593 nobiletin 86.24 µM -1.33429436865346 0.0945879829114257 no 3043 0.0910537012176218 4379 72344 An anti-infammatory.
SGTC_1681 tripelennamine 100 µM -1.33642942604906 0.0942246653660764 no 3044 0.0907044768071217 4302 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_980 1473-0395 201 µM -1.33727298911501 0.0940814023375898 no 3045 0.0905667722388524 4282 768876
SGTC_594 1487-1584 10.8 µM -1.33785553371326 0.0939825621520892 no 3046 0.090471767369439 4343 5013332
SGTC_2150 5556613 200 µM -1.33845631501117 0.0938807080359741 no 3047 0.0903738658753251 4429 743190
SGTC_3115 9123671 49.47 µM -1.33849904542228 0.093873466793495 no 3048 0.090366905655296 4541 3286988
SGTC_2332 7982454 138.89 µM -1.33876437716926 0.0938285119899524 no 3049 0.0903236955253025 4306 2981748
SGTC_2449 5812982 45.77 µM -1.33968302009306 0.0936729902985773 no 3050 0.0901742100944763 4324 776185
SGTC_1174 0739-0097 51.1 µM -1.33974749413416 0.0936620823151676 no 3051 0.0901637255139015 4431 728447
SGTC_901 1112-0062 60.1 µM -1.34451245636083 0.0928585201229713 no 3052 0.0893913655788785 4382 1908457
SGTC_1328 1441-0025 69.2 µM -1.34479325862593 0.0928113252308239 no 3053 0.0893460039506454 4385 4562601
SGTC_1433 4060-0023 7.6 µM -1.34823277765179 0.0922346782130738 no 3054 0.0887917626591653 4419 3840627
SGTC_3254 9136651 49.47 µM -1.3485206981775 0.0921865279169717 no 3055 0.0887454837632413 4353 16454030
SGTC_1236 0330-0013 258 µM -1.35094586326792 0.0917816944470617 no 3056 0.0883563875751485 4411 4617066
SGTC_1465 k213-0056 144 µM -1.35365160306198 0.0913315805648915 no 3057 0.0879237776600885 4293 24048857 YMR208W ERG12
SGTC_2874 9043904 71.43 µM -1.35560109867858 0.0910082875960033 no 3058 0.0876130610473442 4342 4463428
SGTC_1396 3511-0007 98.6 µM -1.35565984969522 0.0909985578639354 no 3059 0.0876037098636546 4431 X1396
SGTC_795 0685-0265 78 µM -1.35635817188872 0.0908829680948071 no 3060 0.08749261751151 4414 302754
SGTC_2845 9003024 42.97 µM -1.35728058005801 0.0907304535243454 no 3061 0.0873460377228673 4456 2990173
SGTC_356 1634-0012 32.5 µM -1.35986935574114 0.0903034299343393 no 3062 0.086935634943993 4406 735457
SGTC_1290 0986-0249 10.2 µM -1.3617643481585 0.0899917947272582 no 3063 0.0866361331348479 4257 53329
SGTC_2572 astragaloside iv 100 µM -1.36422299532148 0.0895886573670436 no 3064 0.086248696484619 4413 45006101 An anti-inflammatory agent.
SGTC_2962 9082311 13.18 µM -1.36536735273786 0.0894014789775744 no 3065 0.086068809798627 4380 16459453
SGTC_2464 5717415 7.67 µM -1.36771477806672 0.0890184297897791 no 3066 0.0857006861711338 4371 5285744
SGTC_2812 7970281 58.44 µM -1.36991051668219 0.0886612396117286 no 3067 0.0853574182070778 4443 2233435
SGTC_995 3931-2021 34.6 µM -1.37068312944283 0.0885358096192734 no 3068 0.0852368780726148 4424 730143
SGTC_2988 9073640 71.4286 µM -1.37145902590295 0.0884099796177214 no 3069 0.0851159540274665 4449 9102229
SGTC_2675 theaflavin digallate 100 µM -1.37376479263445 0.0880368313271884 no 3070 0.0847573572859617 4356 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_828 2074-0507 139 µM -1.37433001599943 0.0879455392130056 no 3071 0.0846696259334096 4475 X828
SGTC_2036 5160441 105 µM -1.37629642677404 0.0876284841775893 no 3072 0.0843649393660776 4391 134534 YIL048W NEO1
SGTC_99 0109-0120 622.8 µM -1.3784249805527 0.0872862480390379 no 3073 0.0840360575603549 4426 759414
SGTC_3223 9129970 49.47 µM -1.37884626362912 0.0872186311649414 no 3074 0.0839710795843048 4442 17248386
SGTC_1771 st048882 4.1505 µM -1.37905885328011 0.0871845249027479 no 3075 0.0839383044484187 4448 4580403
SGTC_1078 idebenone 36.1 µM -1.37921058011896 0.0871601890969585 no 3076 0.0839149184619176 4449 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2992 9074591 71.4286 µM -1.38407400325681 0.0863828185318918 no 3077 0.0831678980799915 4370 17741321
SGTC_1112 tnp00069 1.16933 µM -1.39828781510246 0.0841406047945229 no 3078 0.0810133277156765 4422 145826
SGTC_908 3448-7491 47.7 µM -1.3993312522859 0.083977741297641 no 3079 0.0808568360144659 4438 1203031
SGTC_729 4092-0585 94.1 µM -1.40032538999239 0.0838227929505851 no 3080 0.0807079505111014 4440 2169061
SGTC_149 3970-0822 46.1 µM -1.40058857332046 0.0837818086268966 no 3081 0.0806685699451321 4418 3114250 YBL034C STU1
SGTC_3054 9094397 49.47 µM -1.40080837196404 0.0837475919358509 no 3082 0.0806356922248301 4435 2598354
SGTC_1847 st056231 15 µM -1.4009338465526 0.0837280636507079 no 3083 0.0806169281375578 4422 5393180
SGTC_3347 9188721 44.724 µM -1.40228660485361 0.0835177437936896 no 3084 0.0804148393989781 4448 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2358 9037157 4 µM -1.40599637766145 0.0829430050322784 no 3085 0.0798626002042715 4441 2388925
SGTC_820 1582-0060 59.9 µM -1.41100951412546 0.0821710753350965 no 3086 0.0791209043481823 4468 3848840
SGTC_1252 0493-0875 34.8 µM -1.41645399089241 0.0813388706750419 no 3087 0.0783213129037927 4431 3960963
SGTC_2728 chlorpromazine 9.18 µM -1.42336005090973 0.0802924254159284 no 3088 0.0773159035240235 4539 2726 A thorazine and dopamine antagonist.
SGTC_1121 fusaric acid 630.51 nM -1.42581100703213 0.0799234990460532 no 3089 0.0769614514154173 4427 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1723 st034307 2.5525 µM -1.43207233368852 0.0789868440558263 no 3090 0.0760615606469063 4449 867466
SGTC_2344 7990960 76.95 µM -1.43460737130209 0.0786099918225744 no 3091 0.0756995064425576 4434 140813
SGTC_490 phenamil 164 µM -1.43759213476456 0.0781680331420697 no 3092 0.0752749069341661 4468 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3148 9097893 49.47 µM -1.43932992827259 0.0779115848326945 no 3093 0.0750285335959802 4429 17174100
SGTC_2255 7941087 197.44 µM -1.44018403083715 0.077785778114944 no 3094 0.0749076699877746 4547 935561
SGTC_2270 7924575 90.91 µM -1.44192105573787 0.077530395360862 no 3095 0.0746623227540889 4428 1262135
SGTC_1202 1988-0068 29.6 µM -1.44432202763689 0.0771784459708402 no 3096 0.0743242061809128 4434 2850480
SGTC_1259 0671-0132 43 µM -1.44601730131017 0.0769306743081214 no 3097 0.0740861745938696 4400 X1259
SGTC_2451 5856223 45.7 µM -1.44736317563852 0.0767343998177717 no 3098 0.0738976168364578 4460 2179896
SGTC_412 gemfibrozil 100 µM -1.4482900406007 0.076599452787259 no 3099 0.0737679759202548 4417 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_370 0180-0345 38.7 µM -1.45169942057368 0.0761046164837491 no 3100 0.0732926002534056 4299 3989527
SGTC_1905 st060207 84.5 µM -1.4549702225408 0.075632184028822 no 3101 0.0728387526826238 4463 1948547
SGTC_2833 9001315 45.46 µM -1.45781124359037 0.0752236449519927 no 3102 0.0724462891387024 4416 2989378
SGTC_785 1270-0111 65.3 µM -1.4602591169875 0.0748729917523683 no 3103 0.0721094367410005 4388 6741994
SGTC_1485 3909-9022 254 µM -1.46041521467777 0.0748506734208561 no 3104 0.0720879968944306 4533 714516
SGTC_1414 3917-0015 5.4 µM -1.46694866291717 0.0739210874022386 no 3105 0.0711950105993942 4471 6618702
SGTC_3134 9127454 49.47 µM -1.46890419674466 0.0736445743973464 no 3106 0.0709293880956964 4528 24262820
SGTC_3189 9110682 49.47 µM -1.47207457024466 0.0731979639169585 no 3107 0.070500370847642 4489 17122418
SGTC_799 1310-0557 151 µM -1.47389462286122 0.0729425110748 no 3108 0.0702549828780892 4503 5354492
SGTC_2432 5630864 12.22 µM -1.47861476129611 0.0722831976202208 no 3109 0.0696216526260833 4484 5714970
SGTC_3058 9093861 49.47 µM -1.48080955985967 0.0719781858499858 no 3110 0.069328664167662 4484 17217477
SGTC_1393 3470-5649 58.2 µM -1.48245338015262 0.0717503907423787 no 3111 0.069109849751955 4476 4108395
SGTC_1275 0867-0008 21.1 µM -1.4839324336401 0.0715459014508082 no 3112 0.068913423195429 4463 3422836
SGTC_487 nimodipine 119 µM -1.48517369315486 0.0713746341826247 no 3113 0.0687489093841439 4509 4497 L-type voltage-gated calcium channels inhibitor
SGTC_721 1187-1332 279 µM -1.487561948118 0.0710459915001516 no 3114 0.0684332273953224 4482 25730
SGTC_1286 0929-0070 131 µM -1.48991847223623 0.0707228555438918 no 3115 0.0681228369448455 4545 1420408
SGTC_104 0074-0074 590.992 µM -1.49296711949725 0.070306489985065 no 3116 0.0677228970053693 4345 3943124
SGTC_2427 5545055 42.75 µM -1.49518444003745 0.0700048478614509 no 3117 0.0674331566245645 4431 5372858
SGTC_2314 7727897 200 µM -1.49719839104231 0.0697317357490545 no 3118 0.0671708219569733 4466 900724
SGTC_334 1502-1024 68.5 µM -1.49809389008144 0.0696105607695675 no 3119 0.0670544291572127 4504 3296216
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.4996191709074 0.0694045398219668 no 3120 0.0668565394268116 4544 368090
SGTC_1439 4092-1168 46 µM -1.49999948526098 0.0693532436657963 no 3121 0.066807267936644 4499 2886240
SGTC_1706 st031321 9.9705 µM -1.50091812147299 0.0692294600322968 no 3122 0.0666883702446152 4518 6103185
SGTC_55 0767-0285 6.563 µM -1.5089684129966 0.068151976516012 no 3123 0.0656534275389358 4419 3116166
SGTC_2496 diffractaic acid 79.83 µM -1.51097137690956 0.0678859133021476 no 3124 0.0653978718215222 4490 94870 An apoptosis inducer which activates caspases.
SGTC_2319 6033012 152.6 µM -1.51141134290419 0.067827578120856 no 3125 0.0653418405893286 4459 847246
SGTC_36 0335-0881 14.2 µM -1.5148033481346 0.0673791305079607 no 3126 0.0649111061697318 4396 23828853
SGTC_2069 5228469 200 µM -1.52162602765303 0.066484067427429 no 3127 0.0640514060387732 4506 2835210
SGTC_504 lovastatin 124 µM -1.526104726841 0.0659015325399686 no 3128 0.0634918925415037 4510 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1478 0453-0656 35.7 µM -1.52807218698389 0.0656468830313609 no 3129 0.0632473080478929 4539 5258496
SGTC_1233 0325-0408 14.2 µM -1.5300777932502 0.0653880821456891 no 3130 0.0629987371272887 4539 12874
SGTC_106 0092-0003 11.579 µM -1.53011085130671 0.0653838230153336 no 3131 0.0629946463604113 4432 1072148
SGTC_2352 9027995 87.8 µM -1.53082594182056 0.0652917449228643 no 3132 0.0629062081724888 4472 2997347
SGTC_1505 k297-0037 20.6 µM -1.53136254351571 0.065222715900374 no 3133 0.0628399079806953 4509 4089396
SGTC_1947 st076332 61.6 µM -1.53180640340937 0.0651656600852164 no 3134 0.0627851077208321 4379 24208416
SGTC_1373 2887-0003 58.5 µM -1.5326909147085 0.0650520763869169 no 3135 0.0626760143834297 4470 776948
SGTC_1006 4099-6547 255 µM -1.53669605031936 0.0645396827286484 no 3136 0.0621838793931621 4517 3146833
SGTC_2152 5568786 200 µM -1.54425622816406 0.0635810286052061 no 3137 0.0612631360161192 4543 5399883
SGTC_1173 0443-0020 122 µM -1.54610593854444 0.0633481751201462 no 3138 0.0610394924125917 4514 5331295
SGTC_625 k213-0058 121 µM -1.55079187249144 0.0627612505710778 no 3139 0.0604757844828948 4588 3655420
SGTC_1713 st033146 12.748 µM -1.55082717483985 0.0627568450044844 no 3140 0.0604715531973153 4493 674619
SGTC_2714 st079313 56.9 µM -1.55966671568627 0.0616612773300141 no 3141 0.0594193308061212 4515 2939799
SGTC_2622 2-methoxyxanthone 59.94 µM -1.56469768183419 0.0610444437903844 no 3142 0.0588269061533674 4487 71034 A hepatoprotective.
SGTC_1277 0873-0036 22 µM -1.56605189097382 0.060879234371646 no 3143 0.0586682347578515 4590 5965735
SGTC_754 3474-0146 171 µM -1.56933269343942 0.0604804358246602 no 3144 0.0582852190945798 4515 24762078
SGTC_2198 6589944 200 µM -1.57398661574233 0.0599182372811436 no 3145 0.0577452718672545 4549 5290268
SGTC_2137 5261020 140 µM -1.57618488929371 0.0596541108487017 no 3146 0.0574915999461374 4522 763655
SGTC_24 0417-1663 219 µM -1.57994531229559 0.059204405606316 no 3147 0.0570596955129687 4546 4329390
SGTC_1060 3448-7350 82 µM -1.58322264871181 0.05881464431049 no 3148 0.0566853629911081 4479 570178
SGTC_881 0833-0569 170 µM -1.58552508798914 0.0585420301993261 no 3149 0.0564235407201851 4558 5418700
SGTC_1019 4262-0212 3.4 µM -1.59170226794594 0.0578155382689541 no 3150 0.055725809254543 4542 4677213
SGTC_492 tmb-8 126 µM -1.59512011389354 0.0574166254268009 no 3151 0.0553426892009456 4571 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3159 9100096 49.47 µM -1.59514444670477 0.0574137932131053 no 3152 0.0553399691144847 4502 25236875
SGTC_1726 st035556 14.5795 µM -1.59833176577152 0.057043754911445 no 3153 0.0549845807211187 4573 5919439
SGTC_130 0136-0219 337.655 µM -1.60277327091873 0.05653124353561 no 3154 0.054492360035658 4449 234244
SGTC_2336 9001819 198.65 µM -1.60446454016077 0.0563370422207492 no 3155 0.0543058473206347 4551 2989602
SGTC_2563 tomatine 8.54 µM -1.61087957374963 0.0556052074828417 no 3156 0.0536029864419827 4483 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2684 capsaicin 100 µM -1.61161003087422 0.0555223541073026 no 3157 0.0535234132595458 4579 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1471 k673-0312 37 µM -1.61321235107504 0.0553409495165467 no 3158 0.0533491905018853 4536 24099884
SGTC_1519 esterone 74 µM -1.61674768569252 0.0549423568995277 no 3159 0.0529663780043803 4548 698 A steroid.
SGTC_2244 6635614 200 µM -1.61703147259374 0.0549104598600016 no 3160 0.0529357437402501 4502 836499
SGTC_481 bay k-8644 50 µM -1.61820944287943 0.0547782149500428 no 3161 0.0528087342605286 4518 2303 A calcium channel antagonist.
SGTC_2540 epiandrosterone 100 µM -1.61882115041976 0.054709640948764 no 3162 0.052742875009658 4576 441302 A steroid.
SGTC_2727 riluzole 51.77 µM -1.6270230596023 0.0537967266246669 no 3163 0.0518661001873886 4600 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2024 5144227 134 µM -1.629860698224 0.053483706583005 no 3164 0.0515654708530383 4530 3475211
SGTC_2786 7743617 45.45 µM -1.63725176268542 0.052675170510051 no 3165 0.0507889377056391 4493 583674
SGTC_2867 9039098 71.43 µM -1.63745848837422 0.052652696229146 no 3166 0.0507673529284636 4543 6463460
SGTC_501 nsc-95397 161 µM -1.64058420390381 0.0523138090868212 no 3167 0.0504418780852127 4561 262093
SGTC_93 0109-0045 59.227 µM -1.64385761843836 0.0519607675687376 no 3168 0.0501028081505242 4661 88733
SGTC_1839 st053978 48 µM -1.64939639252518 0.0513677185478205 no 3169 0.0495332266519924 4591 3788398
SGTC_1632 st005650 90 µM -1.65370196951849 0.0509104403318003 no 3170 0.0490940411458391 4590 2759605
SGTC_1571 st070080 73.4 µM -1.6561419745404 0.0506527392765544 no 3171 0.0488465353726343 4559 4315245
SGTC_1361 1608-0041 5.61 µM -1.65713830605982 0.0505478109427714 no 3172 0.0487457580542037 4584 X1361
SGTC_2731 amoxapine 43.43 µM -1.66185669075439 0.0500532454332004 no 3173 0.0482707561017447 4715 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_611 3453-1652 23.7 µM -1.66546980049667 0.0496771458187354 no 3174 0.0479095318953467 4573 1560575
SGTC_2678 equilin 100 µM -1.66576946970518 0.0496460538729692 no 3175 0.0478796696102258 4586 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2666 tannic acid 100 µM -1.66930674035799 0.0492802193312657 no 3176 0.0475283025488311 4556 16134267 A thiamine antagonist.
SGTC_924 2046-0044 21.3 µM -1.67563011058514 0.0486316045517154 no 3177 0.0469053335523877 4545 3623589
SGTC_2561 acetosyringone 100 µM -1.68038156718111 0.0481487328182914 no 3178 0.0464415500382787 4534 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3184 9108758 49.47 µM -1.68126541195476 0.0480593357859878 no 3179 0.0463556865081863 4623 902885
SGTC_277 nystatin 15.5 µM -1.68160334762904 0.0480251901946634 no 3180 0.0463228905181377 4605 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1070 indatraline 8.81 µM -1.68192871158225 0.0479923332202613 no 3181 0.0462913321938818 4615 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1833 st055984 71 µM -1.68493575160401 0.0476895172597143 no 3182 0.0460004839562392 4617 676288
SGTC_887 0885-0007 9.62 µM -1.68654748816824 0.0475278425914814 no 3183 0.0458451982401546 4591 5719458
SGTC_1336 1486-0901 104 µM -1.68828932467759 0.0473536114661917 no 3184 0.045677851732002 4588 5006114
SGTC_1670 st016595 4.04 µM -1.68853997046612 0.0473285822336298 no 3185 0.0456538114653414 4620 597879
SGTC_2987 9018338 71.43 µM -1.689587526733 0.0472240890625388 no 3186 0.045553446946796 4590 5055682
SGTC_2195 6536160 144.242 µM -1.68977416206707 0.0472054917108954 no 3187 0.0455355843775603 4585 3834386
SGTC_2320 7373003 200 µM -1.69094540685118 0.0470889165438495 no 3188 0.0454236149514616 4562 5415828
SGTC_2079 5212404 121 µM -1.69155580078302 0.047028254974235 no 3189 0.0453653499420317 4541 758462
SGTC_3185 9108267 49.47 µM -1.69244681049874 0.046939818031738 no 3190 0.0452804067545066 4577 4910486
SGTC_1766 st045414 44.774 µM -1.70228901281463 0.0459717805550435 no 3191 0.0443506017208799 4584 253960
SGTC_2047 4141938 200 µM -1.70477771629847 0.0457295600660106 no 3192 0.044117944512827 4610 3807862
SGTC_818 4072-2707 53.5 µM -1.70981200714097 0.0452427193279514 no 3193 0.0436503209748807 4530 882871
SGTC_109 0132-0036 33.701 µM -1.71724902350206 0.0445311621822606 no 3194 0.0429668408782193 4519 67274 A color developer.
SGTC_2446 5162541 200 µM -1.71792546581846 0.044466891503166 no 3195 0.0429051055894388 4570 1549321
SGTC_3135 9127742 49.47 µM -1.71881505809516 0.0443824826444114 no 3196 0.0428240263781245 4633 3643468
SGTC_2929 9013348 24.6 µM -1.72126896310844 0.0441503133214233 no 3197 0.0426010143703108 4564 2995952
SGTC_1728 st035614 33.7865 µM -1.72316674208334 0.0439714325354873 no 3198 0.0424291880644829 4548 15945546
SGTC_2214 7179297 48.276 µM -1.72469854830128 0.0438274742750996 no 3199 0.042290906403085 4663 769744
SGTC_2282 7944268 200 µM -1.72879619617895 0.0434442478848484 no 3200 0.0419227885981252 4580 2970414
SGTC_750 4073-0104 132 µM -1.72982460340518 0.0433484934998185 no 3201 0.0418308086289365 4283 22330957
SGTC_2732 terfenadine 20 µM -1.73287543768101 0.0430654343678415 no 3202 0.0415589054182438 4669 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3028 9087778 49.47 µM -1.73358573341909 0.0429997472448611 no 3203 0.0414958068049241 4578 17217395
SGTC_1680 diphenhydramine 100 µM -1.73557139178985 0.0428165458076895 no 3204 0.0413198240137323 4547 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3094 9117742 49.47 µM -1.7384936558538 0.0425480788651009 no 3205 0.0410619334948713 4572 17149698
SGTC_3241 9133421 49.47 µM -1.74557773658951 0.0419029152541966 no 3206 0.040442176824648 4681 17018221
SGTC_1358 1509-0022 2.48 µM -1.75435761198075 0.0411143278648722 no 3207 0.039684624845283 4634 3258434
SGTC_2832 7992762 51.95 µM -1.75532553882018 0.0410281323591992 no 3208 0.0396018202485529 4527 2985177
SGTC_1217 1183-1422 255 µM -1.75672598321325 0.0409036799206857 no 3209 0.0394822632432751 4630 2849664
SGTC_128 0906-2981 13.371 µM -1.75975692703232 0.0406353794205062 no 3210 0.0392245145375305 4604 6740226
SGTC_630 4356-0227 183 µM -1.76011459778376 0.0406038126852658 no 3211 0.0391941890840549 4567 779312
SGTC_2964 9083345 53.42 µM -1.7606441231585 0.0405571152281592 no 3212 0.0391493278144178 4573 17741579
SGTC_82 0054-0107 293.755 µM -1.76337851655492 0.0403166695854378 no 3213 0.0389183353532878 4596 3104697
SGTC_244 nsc-207895 1.295 µM -1.76563220318354 0.040119365757027 no 3214 0.0387287868420959 4431 42640
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.77211575626098 0.0395561205759649 no 3215 0.0381876719798246 4573 6857784
SGTC_1145 3546-0597 10.2 µM -1.77337663401813 0.0394473349663804 no 3216 0.0380831590846485 4604 875334
SGTC_1717 st033143 58.0435 µM -1.77592072547158 0.0392285776186673 no 3217 0.0378729921901726 4611 674616
SGTC_2990 9074105 71.4286 µM -1.78012237590202 0.0388694552454435 no 3218 0.0375279676912082 4548 6502001
SGTC_585 0kpi-0023 191 µM -1.78804997891815 0.0381991625477482 no 3219 0.0368839723834316 4564 64601
SGTC_78 0336-0123 156.75 µM -1.79698143851131 0.0374553158867231 no 3220 0.0361692832651948 4504 6765896
SGTC_615 k087-0205 167 µM -1.79778740222306 0.0373887780505761 no 3221 0.0361053522337428 4634 9642773
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.79932287842641 0.0372622811401638 no 3222 0.0359838105558307 4643 15053
SGTC_439 amiodarone 34.4 µM -1.80257891512112 0.0369951963326321 no 3223 0.035727185424155 4507 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2268 7933382 153.85 µM -1.80710976653786 0.0366261474835162 no 3224 0.0353725830808392 4655 935025 YOR257W CDC31
SGTC_1611 st001856 99.4 µM -1.80856372887679 0.0365083589830948 no 3225 0.0352594038620328 4630 647478
SGTC_1674 st016616 23.6 µM -1.80962973390591 0.0364221967844957 no 3226 0.0351766128582843 4597 625830
SGTC_1043 0916-0009 19.3 µM -1.81047316838676 0.0363541423252817 no 3227 0.0351112208123022 4636 3101130
SGTC_177 1327-0068 8.361 µM -1.819111479388 0.035663114411762 no 3228 0.0344472120372181 4627 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_415 dibenzyl ketone 100 µM -1.82374992919814 0.0352965236009248 no 3229 0.0340949433727007 4619 7593
SGTC_1381 2324-0066 62.1 µM -1.82976456487117 0.0348257769005374 no 3230 0.0336425758166383 4641 10885928
SGTC_3332 9141069 11.198 µM -1.83446039036526 0.0344618430588465 no 3231 0.0332928411516391 4581 17332883
SGTC_76 0433-0009 400.328 µM -1.83545432550776 0.0343852136016548 no 3232 0.0332192003481726 4676 2841569
SGTC_1363 1636-0063 10.4 µM -1.8469977361059 0.0335054646265304 no 3233 0.0323737341993209 4656 6072185
SGTC_2166 5933061 31.504 µM -1.84965869853933 0.0333053168766691 no 3234 0.0321813784086484 4620 2877375
SGTC_3031 9088762 49.47 µM -1.85731264658834 0.0327350984476416 no 3235 0.0316333430977461 4633 205253
SGTC_3286 9117135 37.221 µM -1.85939366573447 0.0325814621285437 no 3236 0.0314856794983173 4590 3438150
SGTC_1534 6-azauridine 81.6 µM -1.86528086674893 0.0321500434854281 no 3237 0.0310710228025994 4675 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3191 9110352 49.47 µM -1.86542910972794 0.0321392412890741 no 3238 0.031060640117435 4608 17122424
SGTC_870 0573-2213 57.6 µM -1.86765596424316 0.0319773346965389 no 3239 0.0309050201706439 4644 3916321
SGTC_556 4058-0063 51.5 µM -1.87382692728529 0.0315321825922399 no 3240 0.030477141855859 4661 6615692
SGTC_1707 st032323 6.317 µM -1.8747862874945 0.0314634398830479 no 3241 0.0304110651982168 4461 3132057 YMR211W DML1
SGTC_505 gw-5074 63.9 µM -1.8839991796956 0.0308095792838059 no 3242 0.0297825432138834 4641 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1261 0712-0010 12.7 µM -1.88942371334149 0.0304298768415519 no 3243 0.0294175379501257 4639 2840123
SGTC_414 piperonyl butoxide 100 µM -1.89867066148354 0.0297915567343921 no 3244 0.0288038956677012 4665 5794 A potent inhibitor of cytochrome P450.
SGTC_1709 st033179 39.1045 µM -1.90276798495084 0.0295122897703766 no 3245 0.0285354132178196 4665 573381
SGTC_2911 7942208 15.64 µM -1.90844711819218 0.0291288058142593 no 3246 0.0281667259270206 4644 1243384
SGTC_1669 st015249 58.4 µM -1.91507099886257 0.0286867671174671 no 3247 0.0277417248715208 4740 722793
SGTC_2234 tolnaftate 200 µM -1.94045168439351 0.0270443311904554 no 3248 0.0261624102847073 4750 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2016 5121758 140 µM -1.94254620813647 0.0269123685193974 no 3249 0.026035505843724 4579 2795203
SGTC_323 4013-0906 34.3 µM -1.96068644235192 0.0257918022292254 no 3250 0.0249578057867953 4695 2910086
SGTC_2806 7952793 58.44 µM -1.96069849029566 0.0257910711772929 no 3251 0.0249571026487256 4661 2972490
SGTC_1021 4476-0760 85.3 µM -1.96633768863227 0.0254507912044438 no 3252 0.0246298080097187 4693 746768
SGTC_383 2324-0395 7.37 µM -1.972542354514 0.0250807425826482 no 3253 0.0242738631128785 4664 3146421
SGTC_582 0987-0078 156 µM -1.97796667449816 0.024760939074511 no 3254 0.0239662331481236 4701 1625765
SGTC_1781 st038725 66.3 µM -1.99109355049092 0.0240011441586157 no 3255 0.0232353016908761 4669 4270275 YIL048W NEO1
SGTC_549 1661-1316 519 µM -1.9937735847605 0.0238484540828455 no 3256 0.023088401783089 4705 2857282
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.9939423257568 0.0238388677573245 no 3257 0.0230791788632707 4673 97141
SGTC_2480 5767542 37.17 µM -1.99724715250327 0.0236517696103392 no 3258 0.0228991705613037 4628 2867358
SGTC_1241 0364-0022 50.8 µM -1.99883414056809 0.0235623643086889 no 3259 0.0228131512545586 4682 4563895
SGTC_2283 7944793 200 µM -2.00360360883904 0.0232953785868266 no 3260 0.0225562694880021 4651 2970533
SGTC_1023 4482-3888 16 µM -2.00815516466408 0.023042970098598 no 3261 0.0223134028658372 4683 3303168
SGTC_823 0417-1665 178 µM -2.0095670165863 0.0229651448085491 no 3262 0.0222385175500945 4700 3429856
SGTC_1671 st016596 74.5 µM -2.01807829172762 0.0225006552877595 no 3263 0.0217915540665784 4722 2829167
SGTC_588 3970-1144 52.9 µM -2.0191135018979 0.0224447044520085 no 3264 0.0217377119145721 4620 1888707
SGTC_2291 7917025 104.35 µM -2.02895302551156 0.0219187336481624 no 3265 0.0212315375478509 4616 2964612
SGTC_792 4534-1957 155 µM -2.02923069806054 0.0219040429825466 no 3266 0.0212173991107631 4659 1717904
SGTC_1335 1486-0900 202 µM -2.03358028904766 0.0216750046566064 no 3267 0.0209969654292457 4693 X1335
SGTC_328 k915-0120 63.5 µM -2.03479795911604 0.021611248965899 no 3268 0.020935603260801 4707 6624543
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.03916103686165 0.0213841033179954 no 3269 0.0207169790727568 4680 23847180
SGTC_209 4077-0173 175.592 µM -2.04785257478603 0.0209376261549474 no 3270 0.0202872235008973 4680 15993494
SGTC_1459 k035-0031 35.7 µM -2.05650986980337 0.0205007769188014 no 3271 0.0198666979628311 4510 3877128 YMR208W ERG12
SGTC_1848 st056003 16.4 µM -2.06653508539372 0.0200045755418695 no 3272 0.0193889915376282 4691 146492
SGTC_2998 9066762 71.4286 µM -2.06790761440424 0.0199374412537547 no 3273 0.0193243556379409 4683 4945196
SGTC_688 0527-0193 473 µM -2.06828971917162 0.0199187854772641 no 3274 0.019306393963861 4713 4007154
SGTC_771 0250-0039 27.3 µM -2.07476827881255 0.0196047257164965 no 3275 0.0190040079137285 4664 3005115
SGTC_3123 9126162 49.47 µM -2.08453665120632 0.0191391414116538 no 3276 0.0185556899874456 4690 25239884
SGTC_210 3551-0445 56.827 µM -2.1021718369798 0.018322394638512 no 3277 0.0177691129450232 4664 2865180 YOR207C RET1
SGTC_341 1486-1430 230 µM -2.1022351629437 0.0183195161523301 no 3278 0.0177663405069413 4686 2054753 YPL210C SRP72
SGTC_467 ro 31-8220 72.8 µM -2.10251809373321 0.0183066602186224 no 3279 0.0177539581820693 4689 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1053 3366-3204 134 µM -2.11089563544106 0.0179294660956375 no 3280 0.0173906416612138 4699 3632071 YPR165W RHO1
SGTC_1943 st076331 65.2 µM -2.12237681570317 0.0174233125534505 no 3281 0.0169030537523241 4686 24208415
SGTC_107 0358-0022 2.6945 µM -2.12272874723302 0.0174079922037934 no 3282 0.0168882943109815 4721 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_860 0443-0016 25.1 µM -2.12550849792586 0.0172873873600264 no 3283 0.0167721028728058 4718 5337942
SGTC_272 doxorubicin 8.13 µM -2.13382469532903 0.0169308262496427 no 3284 0.0164285667954851 4727 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2762 leflunomide 42.06 µM -2.14392065575979 0.0165064246371456 no 3285 0.0160196224168747 4681 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1547 harmine 94.2 µM -2.17991379988946 0.0150666916000651 no 3286 0.0146319259031444 4649 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_416 estradiol valerate 100 µM -2.19540856152244 0.0144809384977257 no 3287 0.0140671517601734 4716 13791 A steroid.
SGTC_336 4111-0029 111 µM -2.202388102358 0.0142235593442096 no 3288 0.0138189527897023 4733 3131175
SGTC_2664 lyso-paf C-16 73.48 µM -2.2156063904393 0.0137469047748156 no 3289 0.0133592354121818 4723 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_68 0986-0284 82.829 µM -2.22314490671489 0.0134812835557002 no 3290 0.0131030151974136 4667 423278 YIL048W NEO1
SGTC_2256 7954252 200 µM -2.22403257475619 0.0134502998957923 no 3291 0.0130731263325611 4737 2972920
SGTC_1797 st048695 56.8 µM -2.24353719133702 0.0127848511895368 no 3292 0.0124310971744403 4715 592262 YIL048W NEO1
SGTC_2723 salbutamol 83.58 µM -2.25604809201498 0.0123731687597189 no 3293 0.0120338097191995 4732 9884233 β2-adrenoceptor agonist
SGTC_1711 st032263 62.8 µM -2.25655226123276 0.0123568221133579 no 3294 0.0120180331129156 4732 3958979
SGTC_854 0422-0053 192 µM -2.25686762844095 0.0123466064959603 no 3295 0.0120081736736602 4750 3596728
SGTC_2484 5809818 12.04 µM -2.26449160300261 0.0121018614715971 no 3296 0.0117719478166694 4705 2870548
SGTC_1466 k213-0079 57.5 µM -2.28277836451085 0.0115318962598859 no 3297 0.0112217135084874 4750 3657981
SGTC_1775 st081588 35.1725 µM -2.29460968775855 0.0111756837295794 no 3298 0.0108777512909173 4717 1426443 YGL099W LSG1
SGTC_889 0919-1524 82.7 µM -2.29711742818119 0.0111014226513951 no 3299 0.0108060359098639 4755 3905452
SGTC_1245 0418-0076 17.2 µM -2.30112621106555 0.0109836028457203 no 3300 0.0106922490873282 4723 6790114
SGTC_1051 3253-3903 78 µM -2.30735673737876 0.0108026443801289 no 3301 0.0105174704680782 4739 5509239
SGTC_1366 1683-0113 21.9 µM -2.32005527868178 0.0104418496209162 no 3302 0.0101689435813047 4742 708623
SGTC_21 0849-0113 22.993 µM -2.32825952308904 0.010214372792834 no 3303 0.00994916361129994 4753 1560156
SGTC_677 0929-0063 136 µM -2.34496412209177 0.00976453424958812 no 3304 0.00951445529742752 4771 1539583
SGTC_380 3970-0968 6 µM -2.36427471008321 0.00926617035603302 no 3305 0.00903270563918944 4717 2891601
SGTC_830 4076-0286 57.8 µM -2.37177573455564 0.00907867265507799 no 3306 0.00885141609797461 4768 6866659
SGTC_1745 st081495 74 µM -2.38880402893203 0.00866531485987557 no 3307 0.00845165804752747 4654 13842402 YBL026W LSM2
SGTC_231 b-estradiol 524 µM -2.39037255525301 0.00862808267389648 no 3308 0.00841564477127495 4763 450 A steroid.
SGTC_1840 st055363 71 µM -2.39684194218004 0.00847599736489933 no 3309 0.00826852772393489 4749 676033
SGTC_2824 7998404 51.95 µM -2.42464541161955 0.00784884477426881 no 3310 0.00766167265744384 4735 837851
SGTC_2357 9067248 200 µM -2.43499737262023 0.00762598612241795 no 3311 0.007445948915997 4712 9150235
SGTC_1824 st053723 68.6 µM -2.47560584179239 0.00680464605652497 no 3312 0.00665051652500229 4768 675225
SGTC_3296 9122258 64.045 µM -2.47801187870507 0.00675853158231746 no 3313 0.00660583733350902 4725 4730474
SGTC_375 3970-0961 9.27 µM -2.47917234697123 0.00673638874050077 no 3314 0.00658438290235049 4750 2898222
SGTC_2912 7964298 10.93 µM -2.49275175410177 0.00648200553187598 no 3315 0.00633787172168476 4745 2975850
SGTC_1683 st010134 710 nM -2.59847981736103 0.00477520154732346 no 3316 0.00468187747009664 4744 3818134
SGTC_75 0159-0059 199.013 µM -2.60766136680836 0.00464785141617476 no 3317 0.00455815452454562 4755 5377270
SGTC_2059 5238311 157 µM -2.61960274525857 0.00448675937276706 no 3318 0.0044016124723608 4750 703021
SGTC_92 0063-0024 660.874 µM -2.63057866931472 0.00434310893708448 no 3319 0.00426198194306598 4789 3594437
SGTC_2383 9036125 200 µM -2.64229286090276 0.00419434368119218 no 3320 0.00411734090684473 4767 79580
SGTC_541 4513-1321 94 µM -2.64866556032836 0.00411534209811342 no 3321 0.00404051284817288 4757 747515
SGTC_2379 9035213 200 µM -2.71575392041773 0.00336097048802299 no 3322 0.0033062523656587 4767 646551
SGTC_2006 4011487 200 µM -2.71633044526165 0.00335506558006343 no 3323 0.00330049984911511 4736 45595294
SGTC_2842 9000675 19.48 µM -2.72590168790768 0.00325838771740933 no 3324 0.00320630477270717 4752 2989072
SGTC_3220 9131269 49.47 µM -2.7518711303169 0.00300857066573126 no 3325 0.00296279170635191 4775 17722206
SGTC_3196 9111891 49.47 µM -2.81028533462027 0.00250858284114084 no 3326 0.00247487979873296 4757 18891510
SGTC_3067 9117431 49.47 µM -2.8113659531865 0.00250008685703906 no 3327 0.00246658208265994 4778 17150885
SGTC_2333 9017922 200 µM -2.81563239273104 0.0024667970328624 no 3328 0.00243406671456839 4753 3163164
SGTC_3217 9129673 49.47 µM -2.87700757828381 0.002030291429782 no 3329 0.00200732976844841 4763 17248312
SGTC_681 1642-0006 26.6 µM -2.8981049405539 0.00189726818062217 no 3330 0.00187712474995445 4794 4446530
SGTC_1107 amlodipine 47 µM -2.95490995534268 0.00157753174237246 no 3331 0.00156380159687784 4471 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2364 9055074 200 µM -3.00593106321535 0.00133307467799776 no 3332 0.00132384508185518 4771 6470630
SGTC_672 1441-0018 53.7 µM -3.0097301338819 0.00131633567968897 no 3333 0.0013073995206435 4797 251141
SGTC_1554 st069299 38.7 µM -3.02948023769716 0.00123237022837499 no 3334 0.00122487465178526 4784 24207999
SGTC_337 1315-0038 354 µM -3.05766545178371 0.00112101336423014 no 3335 0.00111534230341665 4795 1626437
SGTC_74 000s-0487 160.283 µM -3.19871888801071 0.000689967557023007 yes 3336 0.000690198490227956 4760 677548
SGTC_71 0417-1750 47.813 µM -3.2422548851711 0.000591701695461894 yes 3337 0.000592939551200515 4776 6811472
SGTC_2285 7945142 200 µM -3.30658651433131 0.000469959314123357 yes 3338 0.000472200912061384 4788 2970608
SGTC_1075 aripiprazole 15.2 µM -3.36579173117776 0.000378848289184169 yes 3339 0.000381621558693188 4807 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -3.3838210458576 0.000354546295294218 yes 3340 0.000357422895324519 4786 229346 A bile salt which induces apoptosis.
SGTC_1747 st037496 66.6 µM -3.46670232493383 0.000260354728655135 yes 3341 0.000263442518090678 4779 723305
SGTC_1206 3978-0017 132 µM -3.49825319291582 0.000231077971822344 yes 3342 0.000234158156064643 4795 3873677
SGTC_1362 1611-0397 101 µM -3.53632681290325 0.000199841536084507 yes 3343 0.000202866214722504 4804 27816
SGTC_1349 flufenamic acid 69 µM -3.73624819406274 9.10971392640158e-05 yes 3344 9.33931561398808e-05 4798 3371 A non-steroidal anti-inflammatory.
SGTC_44 0929-0055 61.211 µM -3.94695869610807 3.81663662501319e-05 yes 3345 3.95751024939549e-05 4725 1379590
SGTC_1203 3992-3522 103 µM -3.9686574435341 3.48102476028643e-05 yes 3346 3.61393478798922e-05 4792 5322312
SGTC_2368 9071271 200 µM -4.06054986956041 2.34536831627105e-05 yes 3347 2.44786392350137e-05 4806 27209959
SGTC_94 0334-0113 514.748 µM -4.06496791147976 2.30078274750949e-05 yes 3348 2.40195354352842e-05 4807 6795178
SGTC_2841 9004761 38.96 µM -4.31363880707963 7.57436554551961e-06 yes 3349 8.02946167357355e-06 4804 2991039
SGTC_1915 st067105 30.6 µM -4.3526015784578 6.32932675571929e-06 yes 3350 6.72657527099309e-06 4806 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2836 9010338 19.48 µM -4.39047684752018 5.30793202013482e-06 yes 3351 5.65511789822396e-06 4794 2994051
SGTC_1199 1638-0010 4.46 µM -4.5549275067266 2.43200956357077e-06 yes 3352 2.62018236438226e-06 4801 3111136
SGTC_758 0868-0029 16 µM -13.6363475721597 2.34115630447177e-43 yes 3353 1.21725903460985e-42 4808 762687