SGTCid condition conc unit TPO4|YOR273C.score TPO4|YOR273C.strain.pval TPO4|YOR273C.strain.significant TPO4|YOR273C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2900 5328528 85.29 µM 10.0038986363546 1.04105704061853e-22 yes 1 7.32564173568103e-24 1 795359
SGTC_2268 7933382 153.85 µM 9.70050006928365 1.95631545009269e-21 yes 2 1.50012255864978e-22 1 935025 YOR257W CDC31
SGTC_2282 7944268 200 µM 7.39297748143048 4.94020117337561e-13 yes 3 7.17883999474833e-14 1 2970414
SGTC_1212 0520-0165 585 µM 7.38745228345668 5.14210127201554e-13 yes 4 7.48344078677251e-14 3 5403258
SGTC_2475 5812728 15.03 µM 6.59103656446135 1.21099805550754e-10 yes 5 2.18383146072303e-11 3 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_825 1988-2224 89.6 µM 6.28779998943097 8.23542093888878e-10 yes 6 1.60998191501719e-10 13 1180859
SGTC_2869 9037858 32.47 µM 6.25556088436571 1.00441756320788e-09 yes 7 1.98044888190043e-10 1 27187042
SGTC_1693 xanthone 101.9 µM 6.23757276106805 1.1215938783951e-09 yes 8 2.22206208453904e-10 1 7020 An insecticide.
SGTC_2284 7945075 39.21 µM 6.00049846429594 4.66294467507831e-09 yes 9 9.83563558947037e-10 3 1245402
SGTC_137 0438-0332 85.389 µM 5.95017407830188 6.26572849701495e-09 yes 10 1.33928724803186e-09 64 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_674 0498-0004 451 µM 5.8206531194719 1.32527264941289e-08 yes 11 2.9309056676834e-09 4 4231473
SGTC_2652 actinonin 100 µM 5.62882771346921 3.90097318609193e-08 yes 12 9.07192562303528e-09 1 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2283 7944793 200 µM 5.43890997481567 1.09686805189847e-07 yes 13 2.6803766195417e-08 13 2970533
SGTC_291 SEC14.278 35.5 µM 5.42854278201995 1.15938544576976e-07 yes 14 2.84080138070593e-08 5 1068044
SGTC_157 1348-1695 65.819 µM 5.38751144778378 1.44232783783979e-07 yes 15 3.57199633419727e-08 27 5380510
SGTC_423 5-fluorouracil 457 µM 5.37798954649158 1.5169497921782e-07 yes 16 3.76610943339171e-08 5 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3089 9117425 49.47 µM 5.33605009635985 1.89238758785304e-07 yes 17 4.74965832580139e-08 5 9401657
SGTC_120 rhodamine 6G 52.259 µM 5.30814561989659 2.19029011887187e-07 yes 18 5.53730756523829e-08 12 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2936 9038235 15.59 µM 5.14575746723023 5.0526805791137e-07 yes 19 1.33221741582325e-07 6 4749415
SGTC_2783 7738165 71.43 µM 5.08825043856786 6.75206179172335e-07 yes 20 1.80690968929749e-07 10 17201110
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 4.98509871082177 1.12676455473195e-06 yes 21 3.09650936035758e-07 10 6708760
SGTC_301 4119-0100 24.5 µM 4.93398735480437 1.44672416249876e-06 yes 22 4.02838290717434e-07 56 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2790 5423970 71.43 µM 4.76516898588272 3.24487067108563e-06 yes 23 9.43477189063748e-07 41 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2163 5671233 125 µM 4.6551357147927 5.41340878485285e-06 yes 24 1.61883686282834e-06 11 701023
SGTC_2557 derrustone 83.84 µM 4.58542123400002 7.44211974397559e-06 yes 25 2.26536028725278e-06 17 629853 An antioxidant.
SGTC_2549 cedrol 20.94 µM 4.55317738754498 8.60886990208511e-06 yes 26 2.64208400586791e-06 7 6708665 A sedative which affects the nervous system.
SGTC_929 2805-0021 398 µM 4.55065227764688 8.7072537511234e-06 yes 27 2.67399330665463e-06 9 3098024
SGTC_1147 3809-1045 12.3 µM 4.53508836529274 9.33772032904306e-06 yes 28 2.87896866426808e-06 13 325925
SGTC_711 k292-0785 179 µM 4.51930271741034 1.00214492243286e-05 yes 29 3.10218152797911e-06 11 4146315
SGTC_2266 7929956 200 µM 4.51636421883197 1.01538797579823e-05 yes 30 3.14552118788035e-06 17 2967153
SGTC_1947 st076332 61.6 µM 4.48997545434078 1.14201848120778e-05 yes 31 3.56156907133259e-06 11 24208416
SGTC_398 bronopol 33.3 µM 4.47122604108622 1.24097495952396e-05 yes 32 3.88862210678259e-06 21 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2966 9084041 48.03 µM 4.45807110631133 1.31521723118208e-05 yes 33 4.13502354043888e-06 22 17741380
SGTC_1688 st021091 57.6 µM 4.45256759150987 1.34751425342693e-05 yes 34 4.24247589180795e-06 3 3656366
SGTC_2712 st079126 47.7 µM 4.44863328959999 1.37106320751041e-05 yes 35 4.32092071393651e-06 9 3152970
SGTC_2456 5770359 74.46 µM 4.43418594416219 1.46093938226974e-05 yes 36 4.62104175861498e-06 13 3118787
SGTC_688 0527-0193 473 µM 4.42787766898162 1.5019148629916e-05 yes 37 4.75824231606708e-06 9 4007154
SGTC_910 3454-3003 490 µM 4.39887267138866 1.70478252923361e-05 yes 38 5.4407321156897e-06 10 820824
SGTC_277 nystatin 15.5 µM 4.37106743473607 1.92349099647743e-05 yes 39 6.18202982610822e-06 8 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1007 4101-0031 70 µM 4.28433208781791 2.78971877095336e-05 yes 40 9.16444858222151e-06 12 1146276
SGTC_1752 st044819 83.042 µM 4.28204901023055 2.81688266157435e-05 yes 41 9.25900905034235e-06 20 441209 YML126C ERG13
SGTC_2267 7931562 200 µM 4.23540622633246 3.42983712414927e-05 yes 42 1.14069448050548e-05 14 934880
SGTC_288 1315-0019 35.1 µM 4.17858582590094 4.3473459610801e-05 yes 43 1.46663651953948e-05 17 6811474
SGTC_703 3875-0075 71.8 µM 4.14885860733728 4.91536840136996e-05 yes 44 1.6706855052882e-05 7 2850814
SGTC_2897 9048598 12.99 µM 4.01490243208359 8.46001312947392e-05 yes 45 2.97351955479546e-05 13 6467404
SGTC_629 3448-6466 76.7 µM 3.98650830919254 9.47129193633053e-05 yes 46 3.3526390298054e-05 18 573744
SGTC_208 k072-0098 12.366 µM 3.92052392217461 0.00012276971073723 yes 47 4.41783320363794e-05 45 5948901
SGTC_981 1488-1094 54.9 µM 3.91169343775252 0.000127067881031165 yes 48 4.58256024129582e-05 24 3449522
SGTC_2627 acetyl isogambogic acid 100 µM 3.90984517552214 0.000127985188775071 yes 49 4.61776483384284e-05 44 6857789 A caspase activator and apoptosis inducer.
SGTC_3280 9140961 49.47 µM 3.908610213162 0.000128601567598421 yes 50 4.64142984768416e-05 16 4901226
SGTC_3000 9075062 71.4286 µM 3.90535131332298 0.000130241499509538 yes 51 4.70442977468054e-05 19 17057871
SGTC_1346 1488-2224 62.4 µM 3.89349960714744 0.000136372267063222 yes 52 4.94041812662203e-05 21 3722427
SGTC_496 calpeptin 138 µM 3.88603362760239 0.000140372116281653 yes 53 5.09476989710603e-05 17 73364 A calpain inhibitor.
SGTC_1539 benzyladenosine 56 µM 3.844906637948 0.00016444898934055 yes 54 6.02991727207094e-05 18 92208 A nucleotide analog.
SGTC_2247 cerulenin 830 nM 3.79835043660137 0.000196346439744615 yes 55 7.28311411968762e-05 20 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 3.79736250759153 0.000197082115165895 yes 56 7.31219224401443e-05 28 4330530
SGTC_2248 tofa 1.1 µM 3.7008025879619 0.000282795813378497 yes 57 0.000107459315680695 45 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3093 9117344 49.47 µM 3.69353373821992 0.000290485658539121 yes 58 0.000110579576151871 23 24824913
SGTC_2366 9070441 60.58 µM 3.68302803450202 0.000301944386040325 yes 59 0.000115239900634555 38 6837235
SGTC_682 0kpi-0099 17 µM 3.67771981688212 0.000307892812154913 yes 60 0.000117664124631655 80 1714895 YML126C ERG13
SGTC_1836 st055642 81 µM 3.6511008869639 0.000339401527925936 yes 61 0.000130559317839982 24 8571
SGTC_1825 st052143 62.6 µM 3.62789938265943 0.000369283979662836 yes 62 0.000142868283303543 21 674173
SGTC_1775 st081588 35.1725 µM 3.57828083859837 0.00044156883385847 yes 63 0.000172930854904542 35 1426443 YGL099W LSG1
SGTC_1928 4'-methoxychalcone 40.3 µM 3.57022862403123 0.000454468068444097 yes 64 0.000178334897327921 18 641818
SGTC_3151 9099821 49.47 µM 3.5560068926715 0.000478107116467647 yes 65 0.000188267101260828 32 17174189
SGTC_1591 genipin 88.4 µM 3.53942629971796 0.000507102836001977 yes 66 0.000200498861266471 23 442424 A DNA cross-linking agent.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 3.50794667754825 0.000566679644860334 yes 67 0.000225789776461471 38 688664
SGTC_2357 9067248 200 µM 3.49145977736118 0.000600403264023803 yes 68 0.000240194395608164 35 9150235
SGTC_3293 9120939 62.045 µM 3.47195813227194 0.000642683361072911 yes 69 0.000258338454752008 35 934087
SGTC_1005 4092-0690 4.4 µM 3.47149129320084 0.000643728365246065 yes 70 0.000258788057855983 42 1529343
SGTC_296 1222-0039 74.9 µM 3.44800545358201 0.000698370348654205 yes 71 0.00028237131717035 22 5984176
SGTC_1285 0929-0069 65.5 µM 3.44487952731931 0.00070595724892878 yes 72 0.000285656981615834 38 1206237
SGTC_1025 k007-0731 70 µM 3.42819822675146 0.000747744795192298 yes 73 0.000303800814426662 29 6256118
SGTC_1234 0326-0494 15.5 µM 3.38018690232696 0.000881064367707432 yes 74 0.000362182766077261 29 1547813
SGTC_251 melphalan 456.522 µM 3.37305969731591 0.000902621901163936 yes 75 0.000371689168017535 49 460612 A DNA alkylator.
SGTC_156 3474-0145 5.642 µM 3.36213962411564 0.000936593520270685 yes 76 0.000386705029292267 77 2265471
SGTC_860 0443-0016 25.1 µM 3.35333915888353 0.000964821562582956 yes 77 0.000399214019192029 43 5337942
SGTC_2827 7993847 71.43 µM 3.32498327372867 0.00106117292991835 no 78 0.000442119198165338 44 2985692
SGTC_1953 st076800 12.1 µM 3.32446370259677 0.00106301796880569 no 79 0.000442943822101479 75 297591
SGTC_572 0960-0087 17.7 µM 3.29832626711128 0.00115971991544425 no 80 0.000486315238193822 58 6796365
SGTC_2036 5160441 105 µM 3.25472469814747 0.00133911739527442 no 81 0.000567511665478437 109 134534 YIL048W NEO1
SGTC_414 piperonyl butoxide 100 µM 3.24872893244889 0.00136567905958649 no 82 0.000579609433185488 25 5794 A potent inhibitor of cytochrome P450.
SGTC_305 1682-2595 20.8 µM 3.21843018196004 0.00150741504557678 no 83 0.000644471729113259 43 226033
SGTC_1468 k284-1086 134 µM 3.19768814532596 0.00161204851345818 no 84 0.000692670036270181 82 15996457
SGTC_1033 k072-0102 21.3 µM 3.19401510095466 0.0016312526060769 no 85 0.000701543888258659 53 5965931
SGTC_527 4476-4215 268 µM 3.18133697991267 0.00169915085975465 no 86 0.000732985008122581 71 4418754
SGTC_1725 st036284 20.55 µM 3.18070859393539 0.00170258219584741 no 87 0.000734576645403005 63 707914
SGTC_2690 usnic acid 100 µM 3.15489375243516 0.00184911730647673 no 88 0.000802782816056746 66 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_160 3453-0671 289.699 µM 3.15329162993239 0.00185857881637866 no 89 0.000807202183903973 76 5322268
SGTC_1709 st033179 39.1045 µM 3.14914664849392 0.00188326202641446 no 90 0.00081874000485439 42 573381
SGTC_1788 fluconazole 20 µM 3.10670318848216 0.00215370463186331 no 91 0.000945931223040887 101 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1100 amiodarone 5.07 µM 3.10398416606092 0.00217217507784095 no 92 0.000954667744805519 49 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_799 1310-0557 151 µM 3.09463523265349 0.00223678376730088 no 93 0.000985275396772432 67 5354492
SGTC_3204 9114183 49.47 µM 3.08826457648318 0.00228180246485438 no 94 0.00100664570374045 72 17027248
SGTC_537 1334-0398 209 µM 3.06536386840689 0.00245049014949909 no 95 0.0010870266128221 65 5846986
SGTC_2685 mycophenolic acid 18.85 µM 2.99151568396856 0.00307406203903885 no 96 0.00138798139105466 32 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1511 0906-3109 28.5 µM 2.98706140089067 0.00311588842966147 no 97 0.00140836572035322 109 2882180
SGTC_1471 k673-0312 37 µM 2.98564759240448 0.00312927102408035 no 98 0.00141489272370107 41 24099884
SGTC_1174 0739-0097 51.1 µM 2.96422594502137 0.00333846989462078 no 99 0.00151722697389525 81 728447
SGTC_1255 0566-0045 221 µM 2.94396324235532 0.00354783406841485 no 100 0.00162019241177632 79 2788469
SGTC_1759 st043059 70 µM 2.94185553265297 0.00357027511274487 no 101 0.00163126045803148 71 669426
SGTC_2537 larixol 68.93 µM 2.92320673262261 0.00377445044718619 no 102 0.00173223205384142 83 6708759
SGTC_2895 9054447 58.44 µM 2.91845934256015 0.00382807127231817 no 103 0.00175882872352051 43 2697450
SGTC_700 3453-2283 142 µM 2.9182885148405 0.00383001340070834 no 104 0.00175979265394891 85 565664
SGTC_479 n-linoleoylglycine 10 µM 2.91813470080312 0.00383176285728111 no 105 0.00176066099242012 43 6433346 An anti-infammatory.
SGTC_3131 9127911 49.47 µM 2.91117169857352 0.00391171291919126 no 106 0.00180038044217597 72 45595681
SGTC_2591 skatole 100 µM 2.90972845241137 0.00392847025208706 no 107 0.00180871451631537 78 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1331 1472-0049 76.2 µM 2.90173375928257 0.00402246555034423 no 108 0.0018555189483929 77 24051409
SGTC_1394 3474-0001 65.7 µM 2.89823380634247 0.00406424521830496 no 109 0.00187635359035418 90 5017666 YIL048W NEO1
SGTC_2405 ticlatone 3.52 µM 2.87940365971438 0.00429576164187299 no 110 0.00199214004118628 139 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2904 7225135 42.03 µM 2.87038813479193 0.0044107255594621 no 111 0.00204984114031095 32 4446116
SGTC_1656 st012921 11 µM 2.86891343094149 0.00442979002310331 no 112 0.00205942256967553 71 6732821
SGTC_2583 asiatic acid 100 µM 2.8671621643275 0.00445252538361985 no 113 0.00207085365663504 83 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2663 amphotericin b 100 µM 2.84333305351053 0.00477240389869761 no 114 0.00223221956036503 48 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2455 5377712 9.75 µM 2.83852481079884 0.00483938015193847 no 115 0.00226612978685001 69 2243908
SGTC_429 1112-0049 25.5 µM 2.83189090193928 0.00493316219719125 no 116 0.00231368170175875 101 2836170
SGTC_1933 st074711 15.9 µM 2.82118648202981 0.00508790556548976 no 117 0.00239231901878225 115 17250958
SGTC_884 0851-0618 334 µM 2.81858266743229 0.00512619375743363 no 118 0.0024118094127061 75 9642473
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.81128114814129 0.00523493158091297 no 119 0.00246723236180912 93 91467 include heat shock
SGTC_2528 xanthyletin 44.79 µM 2.80621135560378 0.005311635764696 no 120 0.00250639002987573 76 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3285 9112818 20.8695 µM 2.80056900972597 0.00539817627566674 no 121 0.00255062994775281 75 17017947 YPR165W RHO1
SGTC_2849 9019321 12.99 µM 2.790903850956 0.00554933303259044 no 122 0.00262805417319782 93 16489627
SGTC_1797 st048695 56.8 µM 2.79055904332636 0.00555479438268069 no 123 0.00263085511904211 131 592262 YIL048W NEO1
SGTC_2123 5259487 200 µM 2.78839862079513 0.00558912175438375 no 124 0.002648466156014 79 2173474
SGTC_2117 5521686 200 µM 2.78435930541808 0.00565380899694737 no 125 0.00268167920025499 81 803312
SGTC_1417 3966-0327 90.4 µM 2.78366779670746 0.00566494949570597 no 126 0.00268740264940993 76 651118
SGTC_2325 6158266 200 µM 2.77376042301883 0.00582671502127498 no 127 0.00277062346293117 83 3623240
SGTC_1022 4477-0945 21.3 µM 2.77184096917272 0.00585852517669399 no 128 0.00278701305679308 85 4648966
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.76053642688184 0.00604901390425287 no 129 0.00288532611170145 80 5106787 A p450 inhibitor.
SGTC_1472 k841-0093 193 µM 2.75486774590205 0.00614658554560742 no 130 0.00293579321225388 85 X1472
SGTC_947 3447-0010 211 µM 2.75365774234184 0.00616759229666721 no 131 0.00294666812787156 74 748350
SGTC_3141 9094609 49.47 µM 2.74099603947126 0.00639125468665427 no 132 0.00306266229156719 112 25236309 YDL196W YDL196W
SGTC_564 3555-0129 330 µM 2.73765895598657 0.00645138504276654 no 133 0.00309391041771332 36 563260
SGTC_997 3996-0078 137 µM 2.72735866262892 0.00664015285760047 no 134 0.00319218009533651 113 735687
SGTC_2540 epiandrosterone 100 µM 2.72730807657293 0.00664109184369557 no 135 0.00319266956332185 164 441302 A steroid.
SGTC_821 1114-0266 29.2 µM 2.71880985359501 0.00680051311351619 no 136 0.00327586296734229 80 3123235
SGTC_74 000s-0487 160.283 µM 2.71852000825563 0.0068060095473602 no 137 0.00327873448144934 86 677548
SGTC_1213 1315-0166 115 µM 2.71652079724687 0.00684402825582838 no 138 0.00329860251024341 97 768401
SGTC_371 0195-0006 7.36 µM 2.71572604824726 0.00685919391293815 no 139 0.00330653070015971 82 3928593
SGTC_1672 st016598 6.51 µM 2.71264969612302 0.00691817802497252 no 140 0.0033373812901133 156 4665860 YNL267W PIK1
SGTC_2868 9035608 32.47 µM 2.69870260699744 0.00719124530783318 no 141 0.00348051755492151 80 6462614
SGTC_1530 rhein 70.4 µM 2.6923273703783 0.00731919977007185 no 142 0.00354776291605911 88 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1975 st070967 30.8 µM 2.68977643181384 0.00737095806074321 no 143 0.00357499510326625 122 261391
SGTC_3289 9119912 71.43 µM 2.68962339639936 0.00737407336575117 no 144 0.00357663476181913 75 17014829
SGTC_3205 9113483 49.47 µM 2.65471728105859 0.00811568592284084 no 145 0.00396874512018254 120 17018033
SGTC_2315 7733312 200 µM 2.64930159999114 0.00823643707888606 no 146 0.0040329157565831 94 726316
SGTC_151 3013-0144 2.285 µM 2.63750440958654 0.00850495036619469 no 147 0.00417592698472127 119 906558 YHR107C CDC12
SGTC_3033 9090887 49.47 µM 2.63650971950688 0.00852793756411762 no 148 0.00418819002390336 110 19325384
SGTC_2195 6536160 144.242 µM 2.63605927550894 0.00853836520514877 no 149 0.00419375391276663 73 3834386
SGTC_2677 mitomycin C 100 µM 2.63242589940032 0.00862288660815347 no 150 0.00423887570290415 62 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2471 5466956 24.79 µM 2.62684516687769 0.00875413773980851 no 151 0.00430902690533347 56 724419
SGTC_1850 st056238 17 µM 2.61374925351181 0.00906903386348861 no 152 0.00447773671775348 99 5393177
SGTC_2448 5185112 27.17 µM 2.61077375209679 0.00914194867411031 no 153 0.00451688186188563 80 5718189
SGTC_1727 st034309 9.9045 µM 2.60832450149736 0.00920235227028189 no 154 0.00454933272286628 156 870305
SGTC_3170 9103054 49.47 µM 2.6040387038416 0.00930888967751966 no 155 0.00460661759579517 81 16432970
SGTC_669 0108-0021 26.2 µM 2.60177644347083 0.00936555947111066 no 156 0.00463711429748016 201 17201
SGTC_2793 7325131 81.82 µM 2.59010942557304 0.00966263602506419 no 157 0.00479727141415808 91 4176441
SGTC_189 3970-0742 2.116 µM 2.58584893525048 0.00977315544493359 no 158 0.00485697470779995 51 2891807
SGTC_1633 st005664 67.9 µM 2.56854423009394 0.010233477672893 no 159 0.00510633391729254 144 2063822
SGTC_2552 juarezic acid 87.02 µM 2.567014668214 0.010275060742292 no 160 0.00512891365590757 137 1549512
SGTC_1479 0549-0158 134 µM 2.55976745893358 0.0104740944569905 no 161 0.00523711118534482 129 5440202
SGTC_1712 st032288 53.4 µM 2.55440445186591 0.0106235365821717 no 162 0.00531848096360188 333 2883011
SGTC_2421 5690543 90.72 µM 2.55330513973609 0.0106543976465754 no 163 0.00533529837113241 105 3397993
SGTC_3309 9129340 25.759 µM 2.52707257129427 0.0114143443390482 no 164 0.00575088665731686 97 17158987
SGTC_2962 9082311 13.18 µM 2.5175838270596 0.0117006024708648 no 165 0.00590814239275583 115 16459453
SGTC_195 4234-0266 16.654 µM 2.50067240828119 0.0122262579374517 no 166 0.00619788905310909 139 2303354
SGTC_2137 5261020 140 µM 2.49184093348383 0.012508811912876 no 167 0.00635414683393882 135 763655
SGTC_3035 9091303 49.47 µM 2.48635175977687 0.0126872670677227 no 168 0.00645301632345004 59 25237002
SGTC_1843 st055809 45.5 µM 2.47113380607072 0.0131935738374 no 169 0.00673427066404708 111 16413835
SGTC_2756 carbadox 75.1 µM 2.44858119159361 0.0139759806690375 no 170 0.00717100510555399 201 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_927 2425-1185 123 µM 2.4240647919196 0.0148715755589449 no 171 0.00767393347590483 123 730375
SGTC_410 α-linolenic acid 100 µM 2.4210409584189 0.0149853843489973 no 172 0.00773806671509927 129 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2156 5649887 115 µM 2.41497662079351 0.0152158871412132 no 173 0.0078681098553053 128 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2040 5100729 123 µM 2.40222625607697 0.0157104728309412 no 174 0.00814781296011647 131 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2488 5268135 45.7 µM 2.40180490905633 0.0157270495489859 no 175 0.0081572032751621 180 1270356 YLR208W SEC13
SGTC_1435 4092-0789 56.7 µM 2.40117511926767 0.0157518548362529 no 176 0.00817125676140858 105 2248285
SGTC_980 1473-0395 201 µM 2.39384758288099 0.0160429370635125 no 177 0.00833633778215001 89 768876
SGTC_820 1582-0060 59.9 µM 2.39137173779446 0.0161423250593726 no 178 0.00839277389463808 145 3848840
SGTC_3335 9143315 29.6265 µM 2.38147806128068 0.0165447710751977 no 179 0.00862165892139941 109 4899691
SGTC_3338 9144300 39.5675 µM 2.38096760917414 0.0165657657143734 no 180 0.00863361508871287 134 4901274
SGTC_1554 st069299 38.7 µM 2.37763507638306 0.0167033922447538 no 181 0.00871202999775071 138 24207999
SGTC_1299 1079-1439 3.74 µM 2.37506779350526 0.0168100815671681 no 182 0.00877286364498855 116 323161
SGTC_2903 5923464 63.88 µM 2.37398607828319 0.0168552089471341 no 183 0.00879860698201047 88 2876576
SGTC_2894 9048625 32.47 µM 2.3653292865391 0.0172201024461842 no 184 0.0090070230850104 114 4092861
SGTC_2364 9055074 200 µM 2.36392419463022 0.0172799607682422 no 185 0.00904125608286838 117 6470630
SGTC_2726 cimetidine 79.27 µM 2.36366278152313 0.0172911168166633 no 186 0.00904763758551737 74 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3274 9138298 49.47 µM 2.36038276614879 0.0174316182441385 no 187 0.0091280437717245 133 17015756
SGTC_1993 st073995 70.8 µM 2.35917890178099 0.0174834304970617 no 188 0.00915771182794031 125 3098394
SGTC_2147 5545932 89.7195 µM 2.35846994864071 0.0175140040933856 no 189 0.00917522274747146 104 797404
SGTC_2994 9053520 71.4286 µM 2.35699636120548 0.0175776985924285 no 190 0.00921171369450129 127 4647384
SGTC_504 lovastatin 124 µM 2.35382314042241 0.0177155298109997 no 191 0.00929072478263695 95 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_230 MPP+ 141.667 µM 2.3485428067858 0.017946929075332 no 192 0.00942351633230709 132 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_279 1273-0055 2.93 µM 2.34769679860971 0.0179842420944542 no 193 0.0094449455932413 167 2847562
SGTC_2735 sertaconazole 140 nM 2.34661516004012 0.0180320438753069 no 194 0.00947240540253329 71 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2260 7964312 200 µM 2.33660937606878 0.0184793966354981 no 195 0.00972975224663669 117 231951
SGTC_330 1488-0319 80.1 µM 2.32473680076888 0.0190224405101078 no 196 0.0100430191010026 122 6846614
SGTC_3047 9092122 49.47 µM 2.31888929137421 0.0192948521811961 no 197 0.0102005199607699 143 17173831
SGTC_1531 st059297 52.4 µM 2.31836937803772 0.0193192325215331 no 198 0.0102146274055594 142 7566702
SGTC_2780 5215298 71.43 µM 2.31513262104941 0.019471603570643 no 199 0.0103028376365831 179 2834131
SGTC_2705 st078069 42.8 µM 2.31378791370861 0.0195352054603516 no 200 0.010339679334832 115 1530061
SGTC_21 0849-0113 22.993 µM 2.31123444224506 0.0196564651171218 no 201 0.0104099544492142 178 1560156
SGTC_1663 st014140 55.4 µM 2.30998858809416 0.0197158600324619 no 202 0.0104443929655527 156 4207120
SGTC_2822 7994718 71.43 µM 2.30711293312098 0.0198535360852457 no 203 0.0105242625727922 115 1018011
SGTC_1822 st052468 42 µM 2.30532801306764 0.0199394013696185 no 204 0.0105741048971603 109 2873678
SGTC_930 2810-3379 265 µM 2.2971012218234 0.0203392429498037 no 205 0.0108064980484156 152 1015764
SGTC_256 clotrimazole 625 nM 2.29358457445956 0.0205122224990264 no 206 0.0109071861381073 179 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.29100158658146 0.0206400690673512 no 207 0.0109816609495052 165 115019
SGTC_2172 5754775 163.918 µM 2.29096944736509 0.0206416640590661 no 208 0.010982590393363 161 2263357
SGTC_1490 4089-0339 670 nM 2.28530650461987 0.0209243367453803 no 209 0.0111474309005848 89 742542
SGTC_2423 st077119 87.2 µM 2.28211064712102 0.0210853032990142 no 210 0.0112414042804722 144 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2654 protoveratrine a 100 µM 2.27582204930385 0.0214051030322428 no 211 0.0114283312439927 116 5702278 A heart drug and vasodilator.
SGTC_3213 9129884 49.47 µM 2.26695186809272 0.0218631505778829 no 212 0.0116965830861078 126 17190742
SGTC_2706 st078239 82.5 µM 2.25595505125173 0.0224424822806138 no 213 0.0120367231391572 148 15434492
SGTC_2992 9074591 71.4286 µM 2.23989424239446 0.0233118188117815 no 214 0.0125488947625664 122 17741321
SGTC_221 trifluoperazine 10.304 µM 2.23756723099765 0.0234400953706872 no 215 0.012624645242278 394 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2927 9011802 47.9 µM 2.21979068192658 0.0244397584573611 no 216 0.0132164898732814 175 43912568
SGTC_677 0929-0063 136 µM 2.21929555887346 0.0244681062048735 no 217 0.0132333117798445 103 1539583
SGTC_2086 5274770 176.623 µM 2.21791514064967 0.02454728637069 no 218 0.0132803094825622 161 689278
SGTC_971 1315-0384 26.7 µM 2.21387078225281 0.024780507839551 no 219 0.0134188345808068 179 6769120
SGTC_792 4534-1957 155 µM 2.20899897166009 0.0250639101913336 no 220 0.0135873562157139 182 1717904
SGTC_570 0987-0065 62.6 µM 2.19869088358985 0.0256725138433696 no 221 0.0139499548115293 104 3104428
SGTC_1877 wortmannin 25 µM 2.1909275998328 0.0261389935758541 no 222 0.0142285160541592 271 312145 A covalent inhibitor of PI 3-kinase.
SGTC_58 0957-0393 9 µM 2.1903553804082 0.0261736557568227 no 223 0.0142492366666385 636 6997992
SGTC_2141 5621638 7.665 µM 2.18990948854348 0.0262006922841344 no 224 0.0142654008505472 147 2856238
SGTC_2947 9072639 7.68 µM 2.18935243227421 0.0262345020390784 no 225 0.0142856170836637 229 16488146
SGTC_3139 9095020 49.47 µM 2.18781539895906 0.0263279793573634 no 226 0.0143415258662767 98 25236292
SGTC_2985 9022375 71.43 µM 2.17958747147778 0.0268331213495848 no 227 0.0146440271602307 190 4939335
SGTC_133 0724-0033 378.92 µM 2.17215725334612 0.0272962180562283 no 228 0.0149219018578086 150 280309
SGTC_1737 st035557 69.7 µM 2.17206387484723 0.0273020801266498 no 229 0.0149254226655347 146 5716916
SGTC_652 0437-0092 114 µM 2.16344706186557 0.0278475592925927 no 230 0.0152534056063165 149 3091274
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.15983766963923 0.0280787313578952 no 231 0.015392619183517 194 1377
SGTC_2095 5432005 200 µM 2.14977976490225 0.0287313575202649 no 232 0.01578631976081 143 783734
SGTC_144 4161-2749 112.381 µM 2.14323952004511 0.0291624639180803 no 233 0.0160469352129558 141 797501 YMR168C CEP3
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.13795092530516 0.0295149839618125 no 234 0.0162603632115427 183 6708514
SGTC_132 0417-1715 25.805 µM 2.13686893739977 0.0295875398203569 no 235 0.0163043265607775 171 6769098
SGTC_1547 harmine 94.2 µM 2.13356112436633 0.0298102735005384 no 236 0.0164393615616274 245 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1055 3448-0672 86 µM 2.13322751512389 0.0298328143059552 no 237 0.0164530335103701 201 748378
SGTC_1063 disulfiram 1.84 µM 2.13288569842367 0.029855924323499 no 238 0.0164670519120092 183 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1088 bifonazole 369 nM 2.12931827315073 0.0300980031768824 no 239 0.0166139684872634 161 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_339 3091-4833 71.4 µM 2.12494324251303 0.0303971040064783 no 240 0.0167956745695309 158 3240077
SGTC_1676 st018489 23.4 µM 2.12404883338127 0.0304585528796593 no 241 0.0168330301827977 224 3696235
SGTC_3156 9099931 49.47 µM 2.12221869162559 0.0305846104375899 no 242 0.0169096888117146 169 18111053
SGTC_748 act1.228 77.9 µM 2.11611468076841 0.0310081736100778 no 243 0.0171675275943017 275 4421505 YNR035C ARC35
SGTC_911 3456-4043 236 µM 2.11519297476676 0.0310725515155929 no 244 0.0172067517327038 224 914281
SGTC_3208 9114115 49.47 µM 2.11382703362119 0.0311681610215809 no 245 0.0172650215596737 216 650895
SGTC_3258 9138477 49.47 µM 2.11282237990545 0.0312386373037843 no 246 0.0173079867024622 158 4970355
SGTC_1636 st007707 68.9 µM 2.11265934228975 0.03125008678474 no 247 0.0173149677950998 232 403051
SGTC_2347 9049783 174.81 µM 2.11069421202758 0.0313883632698343 no 248 0.0173993019069204 238 6467988 YPL169C MEX67
SGTC_2203 7227154 166.4 µM 2.10740113865283 0.0316212145237548 no 249 0.0175414114997661 157 896304
SGTC_3171 9103192 49.47 µM 2.09813461701025 0.0322841153835715 no 250 0.0179466276769738 121 13018434
SGTC_268 camptothecin 39.6153 µM 2.09074112676438 0.0328212141608425 no 251 0.0182756380819564 319 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3223 9129970 49.47 µM 2.0858302621629 0.0331820181299202 no 252 0.0184970005684903 197 17248386
SGTC_1997 st073024 93.8 µM 2.07929779395503 0.0336670197276884 no 253 0.0187949938870713 165 686268
SGTC_2259 7964009 200 µM 2.07843552427532 0.0337314724138487 no 254 0.0188346318116655 192 313134
SGTC_2314 7727897 200 µM 2.07792962340823 0.0337693345817035 no 255 0.0188579208043584 176 900724
SGTC_474 dl-dihydrosphingosine 5 µM 2.07707124732633 0.0338336563689021 no 256 0.0188974919365146 215 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2695 st077686 51.995 µM 2.06887364147711 0.0344530296925782 no 257 0.019278972820681 208 2876092
SGTC_1230 0170-0365 3.77 µM 2.06639639628383 0.03464202153403 no 258 0.0193955329686296 331 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_119 0121-0043 24.815 µM 2.06282604196786 0.0349159050671797 no 259 0.0195645794263095 391 1092378
SGTC_2155 5570423 76 µM 2.06173593099198 0.0349998813120658 no 260 0.019616441874 166 797402
SGTC_1265 0819-1001 68.8 µM 2.06062787494778 0.0350854097527617 no 261 0.0196692776565954 195 3106768
SGTC_2871 9038510 12.99 µM 2.06010935775035 0.0351254918348895 no 262 0.0196940437441561 193 4945164
SGTC_1094 duloxetine 25.4 µM 2.05810168674423 0.0352810420449173 no 263 0.0197901865705603 211 60834 A selective serotonin reuptake inhibitor.
SGTC_331 k048-0133 24.5 µM 2.04964139152298 0.0359427473025603 no 264 0.0201997190699009 152 6813582
SGTC_2779 methotrexate 400 µM 2.04729396421754 0.0361281377651065 no 265 0.0203146150882206 220 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1609 st001574 46.4 µM 2.03033792444518 0.0374906318775078 no 266 0.0211611008937244 213 3960012
SGTC_3118 9124250 49.47 µM 2.02390775708657 0.0380181769648586 no 267 0.0214898218265184 177 1504786
SGTC_647 0140-0236 81 µM 2.01919162682868 0.0384089356926176 no 268 0.0217336531357304 219 990837
SGTC_3027 9089541 49.47 µM 2.01533201870159 0.0387311571819683 no 269 0.0219349360952577 220 9943819
SGTC_1202 1988-0068 29.6 µM 2.00959733951403 0.0392139835169775 no 270 0.0222369115361171 236 2850480
SGTC_2892 9047358 58.44 µM 2.00478392451781 0.0396230161489461 no 271 0.0224930759201945 153 6466771
SGTC_1481 3346-2004 36 µM 2.00156399539545 0.039898569976311 no 272 0.0226658222882175 200 2770522
SGTC_781 4335-2806 94.4 µM 1.98857969658436 0.0410255792635736 no 273 0.0233738071342755 239 845254
SGTC_131 0141-0277 33.849 µM 1.98357144134394 0.0414671272006969 no 274 0.0236518177612008 253 1547771
SGTC_1050 3232-1156 69.3 µM 1.98283654187171 0.0415322416983459 no 275 0.0236928454105595 233 700529
SGTC_502 l-744,832 89.3 µM 1.98269558245433 0.04154474062783 no 276 0.0237007216681779 223 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.97738684600078 0.0420176914654374 no 277 0.0239989598458555 169 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_250 brefeldin a 552.239 µM 1.97348151916491 0.0423683885801643 no 278 0.0242203640395619 154 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2893 9048488 25.97 µM 1.97327400876908 0.0423870889983348 no 279 0.0242321762409257 207 6467338
SGTC_596 1155-0152 116 µM 1.97225643946907 0.042478886955526 no 280 0.0242901698200653 296 280313
SGTC_1070 indatraline 8.81 µM 1.96427900722605 0.0432041385829784 no 281 0.0247488724050304 242 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2012 4023501 200 µM 1.96279028979151 0.0433405831702837 no 282 0.0248352732813717 226 3477460
SGTC_2313 7726885 200 µM 1.96156459458127 0.0434531820961657 no 283 0.024906598857064 249 726423
SGTC_635 k038-0028 24.7 µM 1.96110276415279 0.0434956695164262 no 284 0.0249335181806318 260 4035102
SGTC_1848 st056003 16.4 µM 1.9603617598431 0.0435639104015921 no 285 0.0249767610552709 224 146492
SGTC_2714 st079313 56.9 µM 1.9500363421589 0.0445238236468258 no 286 0.0255858937981018 212 2939799
SGTC_794 k038-0031 316 µM 1.94780357470768 0.0447336197174696 no 287 0.0257192354506247 346 6624242
SGTC_1114 scopoletin 1.73284 µM 1.94234640736105 0.0452497395403679 no 288 0.0260475892531427 205 5280460 A coumarin with genotoxic properties.
SGTC_1056 3448-1962 115 µM 1.94133266385475 0.0453461414440304 no 289 0.0261089700108839 211 715507
SGTC_2526 patulin 37.61 µM 1.94001340566846 0.0454718435614479 no 290 0.0261890303533364 350 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2830 7992007 71.43 µM 1.93969129167846 0.0455025778865165 no 291 0.0262086092718341 221 1952075
SGTC_3344 9148862 3.898 µM 1.93344576423814 0.0461017999430593 no 292 0.0265906541111188 219 4905352
SGTC_1722 st034304 3.6505 µM 1.9326499740087 0.0461786045780497 no 293 0.0266396658641487 266 4036148 YLR033W RSC58
SGTC_424 splitomicin 100 mM 1.92587248006617 0.046836897478913 no 294 0.0270601492310623 240 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3016 9080866 49.47 µM 1.92453206969167 0.0469679778489661 no 295 0.0271439624606071 256 17066299
SGTC_285 1486-1325 46 µM 1.91743985136004 0.0476664381233802 no 296 0.027591037756216 249 22310230
SGTC_3324 9138759 60.749 µM 1.91478337387835 0.0479301867587973 no 297 0.0277600678325349 235 45595710
SGTC_1926 methyl fluorone black 53.6 µM 1.91335793041411 0.0480721929237218 no 298 0.0278511231047276 265 72721 Reacts with homocysteine.
SGTC_2179 6298986 200 µM 1.91138295526705 0.0482695009841622 no 299 0.0279776927404597 211 738374
SGTC_1504 k297-0033 30 µM 1.90963368616235 0.0484448006285616 no 300 0.0280901973402836 204 4388117
SGTC_2122 5258151 111.688 µM 1.90872752290914 0.0485358100162838 no 301 0.0281486253707198 261 2173356
SGTC_812 4251-0442 148 µM 1.9030806760245 0.0491060283842954 no 302 0.0285150095089483 211 5723007
SGTC_318 1488-0629 67.2 µM 1.89961204598582 0.0494589351425961 no 303 0.0287420251183438 214 3662576
SGTC_1512 0259-0544 12.2 µM 1.89880713801138 0.0495411171264171 no 304 0.0287949191734874 275 18476
SGTC_1180 1193-0155 285 µM 1.89740148884132 0.0496848967586606 no 305 0.0288874846461369 251 2921347
SGTC_3246 9135460 32.98 µM 1.89726736242076 0.0496986335299028 no 306 0.0288963301146864 162 41446951
SGTC_615 k087-0205 167 µM 1.89582968030918 0.0498460664286482 no 307 0.0289912849152144 224 9642773
SGTC_892 0929-0076 29 µM 1.89552734778136 0.049877114685973 no 308 0.0290112860789666 321 5751038
SGTC_1104 tacrolimus 29.8 µM 1.89296391029825 0.0501409890174868 no 309 0.0291813345172386 259 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1313 1220-0047 237 µM 1.89166895224742 0.0502747114816439 no 310 0.0292675512685478 310 3528706
SGTC_1454 4239-0054 42.6 µM 1.88342440806026 0.0511327533983615 no 311 0.0298214375736384 294 1340767
SGTC_817 1391-0715 46 µM 1.88064777888276 0.0514243373009062 no 312 0.0300099238688378 231 1353946
SGTC_738 1315-0003 72.4 µM 1.87407455669779 0.0521198868783779 no 313 0.0304600748160723 265 6251474
SGTC_3234 9132280 49.47 µM 1.86949613973018 0.0526087549594104 no 314 0.0307769101018647 268 17612295
SGTC_1795 st049545 62.3 µM 1.86635031140007 0.0529467601476536 no 315 0.0309961850513197 223 5291882
SGTC_2911 7942208 15.64 µM 1.86526475528525 0.0530637972249905 no 316 0.0310721513949915 234 1243384
SGTC_1931 st074438 57.1 µM 1.85883829294724 0.053760860980026 no 317 0.0315250314260484 230 2787313
SGTC_2715 st079500 56.4 µM 1.85782676737034 0.0538712364375379 no 318 0.0315968093252039 218 28246688
SGTC_1072 oxiconazole 14.9 nM 1.85242756410012 0.0544634236577431 no 319 0.0319822251095615 305 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2060 5238662 140 µM 1.8468144238895 0.0550845223407184 no 320 0.0323870203373156 259 790130
SGTC_2045 5106652 78.05 µM 1.83756787554865 0.0561198475831391 no 321 0.0330630530635908 245 673349
SGTC_1441 4106-0040 13 µM 1.83719093560952 0.0561623764311536 no 322 0.0330908566717716 250 2904180
SGTC_3102 9121669 49.47 µM 1.83544324396253 0.0563598946876726 no 323 0.0332200206413072 210 41905072
SGTC_346 4513-0042 7.16 µM 1.82965991066961 0.05701741364715 no 324 0.0336504045413773 300 2827372
SGTC_951 1171-0579 82.7 µM 1.82864738903136 0.057133148058903 no 325 0.0337262243206957 381 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1158 4092-0494 91.8 µM 1.82548776051494 0.0574954926894558 no 326 0.0339637282623044 273 1148199
SGTC_2952 9073731 13.78 µM 1.82396184604356 0.0576711299109838 no 327 0.0340789202911295 322 16457353
SGTC_760 0568-0725 82.9 µM 1.81537076869463 0.0586678751082187 no 328 0.034733475061935 252 3916171
SGTC_2470 5664817 21.68 µM 1.81432604154096 0.0587900020423451 no 329 0.0348137723010045 237 2859561
SGTC_2692 st077426 47.7 µM 1.80853118615229 0.0594710376510467 no 330 0.0352619337963472 289 25238571
SGTC_2704 st078022 71.1 µM 1.80048434517445 0.0604269732336073 no 331 0.0358920966502256 273 54697681
SGTC_2185 6113692 200 µM 1.79825503529014 0.0606939230465635 no 332 0.036068300865552 254 874150
SGTC_2618 avocadyne 43.43 µM 1.79061304025971 0.0616160225733828 no 333 0.0366777064854392 262 3015189
SGTC_126 0417-1624 672.48 µM 1.78739411002533 0.0620076847717949 no 334 0.0369369064632541 376 41912 YDL195W SEC31
SGTC_76 0433-0009 400.328 µM 1.78551109018614 0.0622376995483693 no 335 0.037089227047836 223 2841569
SGTC_332 4112-0506 40.9 µM 1.78171368069397 0.0627035848400802 no 336 0.0373979673900926 272 2790355
SGTC_1416 3966-0321 25.3 µM 1.78125181999325 0.0627604331344751 no 337 0.0374356607678699 302 582530 YLR208W SEC13
SGTC_2826 7992541 19.48 µM 1.77807090531913 0.0631530486876933 no 338 0.0376961051060607 293 2985066
SGTC_1963 st076565 50.3 µM 1.77470097286528 0.063571078172406 no 339 0.0379736373065469 277 4914280
SGTC_782 0083-0095 30.5 µM 1.76889420963694 0.0642964366351253 no 340 0.0384557653413708 350 3591729 An indicator and reagent.
SGTC_2356 9061756 188.97 µM 1.76784400916076 0.0644283078019622 no 341 0.0385434926524433 234 20104043
SGTC_454 lyso-paf C-16 6.67 µM 1.75908044185534 0.0655369357060119 no 342 0.0392819231875518 290 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.75601990397041 0.0659275727680471 no 343 0.0395425050168449 272 97141
SGTC_3179 9107801 49.47 µM 1.75550791712929 0.0659930969034115 no 344 0.0395862338183576 280 4818259
SGTC_2337 9009472 200 µM 1.75549584951102 0.0659946419270646 no 345 0.0395872649879913 346 5742383
SGTC_2566 crystal violet carbinol 226 nM 1.75019502419577 0.0666760235091626 no 346 0.0400423335702008 281 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1955 wogonin 32.4 µM 1.7436903803269 0.0675195717335969 no 347 0.0406065468432076 284 5281703 A flavanone.
SGTC_1842 st055362 61.2 µM 1.74053182348282 0.0679321493446601 no 348 0.0408828385660551 343 676032
SGTC_3054 9094397 49.47 µM 1.73465102679484 0.068705495022882 no 349 0.0414013177701161 344 2598354
SGTC_3111 9122088 49.47 µM 1.73353114829376 0.0688535295589209 no 350 0.0415006530803127 198 16876704
SGTC_248 streptozotocin 5.23457 mM 1.73225796846423 0.0690221272571881 no 351 0.041613820994248 331 5300 DNA alkylating agent.
SGTC_3203 9113543 49.47 µM 1.72771040379273 0.0696269260058598 no 352 0.0420200786886308 326 17018012
SGTC_2760 etidronate 98.04 µM 1.72531589404779 0.069947016945343 no 353 0.042235279565472 343 3305 A chelator and antioxidant.
SGTC_2928 9011484 9.79 µM 1.72452607795264 0.0700528451794803 no 354 0.0423064576836045 284 2994751
SGTC_2411 st077133 39.94 µM 1.72376050844817 0.070155542114263 no 355 0.0423755432945854 374 1403142 YNL221C POP1
SGTC_1571 st070080 73.4 µM 1.7215993038614 0.0704460807276769 no 356 0.0425710646961762 315 4315245
SGTC_2194 5927483 104.545 µM 1.7214362685529 0.0704680356260873 no 357 0.0425858438330975 338 760979
SGTC_311 1315-0136 58 µM 1.71945674308845 0.0707350252047907 no 358 0.0427656188436431 281 6759207
SGTC_113 0099-0221 2.5 µM 1.71919803059618 0.07076997655 no 359 0.0427891596537976 302 89219
SGTC_425 3825-7017 13.1 µM 1.71891992475794 0.0708075626801725 no 360 0.0428144767863632 359 3397440
SGTC_40 0327-0103 19.753 µM 1.71686214174609 0.0710861497405858 no 361 0.0430021817681391 318 409036
SGTC_1994 st072947 40.9 µM 1.7167262752402 0.0711045732187331 no 362 0.0430145984778216 320 5286565 YDL195W SEC31
SGTC_2223 6903751 107.57 µM 1.71630647362488 0.0711615214233458 no 363 0.04305298204786 236 5598863
SGTC_3023 9089636 49.47 µM 1.7106986930301 0.0719256075452194 no 364 0.043568374553087 295 17249241
SGTC_2860 9025725 38.96 µM 1.70960471142579 0.0720753982841237 no 365 0.0436694969170806 280 40546248
SGTC_3007 9078383 71.4286 µM 1.70773612550033 0.0723318027389239 no 366 0.04384265789686 317 6496995
SGTC_676 falcarinol 140 µM 1.70565310480357 0.0726184548213684 no 367 0.0440363428594964 352 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_889 0919-1524 82.7 µM 1.70335978603955 0.0729350521470599 no 368 0.0442503792527354 308 3905452
SGTC_1617 st002906 78 µM 1.70323775502721 0.0729519283362196 no 369 0.0442617919134605 338 5150859
SGTC_476 mead acid 10 µM 1.7021619104454 0.0731008408299257 no 370 0.044362510412546 217 5312531 An omega 9 fatty acid.
SGTC_129 0088-0017 176.636 µM 1.7017249454289 0.0731613895067643 no 371 0.0444034709418891 351 182446
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.69990020529415 0.0734146519903834 no 372 0.0445748491547234 286 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1999 st074831 12.5 µM 1.69942804196779 0.0734802943711846 no 373 0.0446192810411263 344 17112523
SGTC_1262 0737-0114 49.6 µM 1.69686335177116 0.0738376340319228 no 374 0.04486124905623 380 765919
SGTC_3078 9116413 49.47 µM 1.69373024605688 0.0742759717558636 no 375 0.0451582771266897 307 17177322
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.69341291139846 0.0743204791153987 no 376 0.0451884494799547 380 676296 Flavone; oxidizing agent.
SGTC_3197 9113331 49.47 µM 1.69178268113737 0.0745494460409234 no 377 0.0453437084615551 358 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1163 k060-0048 49.9 µM 1.68617145882387 0.0753416631610511 no 378 0.0458813897488407 370 6809982
SGTC_1282 0886-0010 32.4 µM 1.68077619356812 0.0761094263837679 no 379 0.0464031972107874 362 2836211 YNL267W PIK1
SGTC_796 1234-0020 70.7 µM 1.68065923340134 0.0761261358934777 no 380 0.0464145616472818 336 46495034
SGTC_946 3434-1334 87.4 µM 1.67174475076915 0.0774079377609469 no 381 0.047287332810773 335 4047976
SGTC_1981 st071826 47 µM 1.67128470351505 0.0774745294771436 no 382 0.0473327281732434 296 11838600
SGTC_451 chloral hydrate 100 µM 1.66999813105798 0.0776609914517287 no 383 0.0474598666892054 425 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2865 9030313 51.95 µM 1.66964361923979 0.0777124304063733 no 384 0.0474949474298975 289 42562754
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.66753735740632 0.0780185782244277 no 385 0.0477038012746823 454 6708739 YPR165W RHO1
SGTC_1605 st000082 49.1 µM 1.665562673499 0.0783064313002408 no 386 0.0479002754297277 309 1114022
SGTC_1217 1183-1422 255 µM 1.6627766488077 0.0787139236779488 no 387 0.0481785762804689 324 2849664
SGTC_2799 7812892 81.82 µM 1.66123110011926 0.0789406721936761 no 388 0.0483335208546842 364 20205235
SGTC_51 1013-0126 23.419 µM 1.66053863371283 0.0790424247762024 no 389 0.0484030712747179 328 1627850
SGTC_3252 9135871 49.47 µM 1.65870903157688 0.0793117485787952 no 390 0.0485872192943438 325 17682838
SGTC_2051 5263410 176 µM 1.65843742855068 0.0793517886359364 no 391 0.0486146036100547 338 227584
SGTC_876 0720-0963 56.8 µM 1.65749537612117 0.0794907857587234 no 392 0.0487096814730616 354 765861
SGTC_2723 salbutamol 83.58 µM 1.65390246222348 0.0800226016149046 no 393 0.0490736661501598 222 9884233 β2-adrenoceptor agonist
SGTC_3153 9100258 49.47 µM 1.64871363033106 0.0807953838303707 no 394 0.0496031582019108 348 25236848
SGTC_2713 st079149 53.4 µM 1.64641870986611 0.0811389623043624 no 395 0.0498387918279465 365 3103253
SGTC_3286 9117135 37.221 µM 1.64147857907352 0.0818823014683109 no 396 0.0503490550485057 356 3438150
SGTC_2982 9019404 25.97 µM 1.64044677960998 0.0820382017182148 no 397 0.0504561527904141 323 22333232
SGTC_155 k072-0202 43.6 µM 1.63390051645426 0.0830325269678146 no 398 0.0511398706492748 312 5857737
SGTC_1640 st009078 66.4 µM 1.63377396004005 0.0830518387972061 no 399 0.0511531609909055 287 690618
SGTC_165 k038-0023 64.381 µM 1.63060255632151 0.083536881641263 no 400 0.0514871047161068 435 46368543
SGTC_211 3455-0679 143.504 µM 1.6278813861807 0.0839547588092058 no 401 0.05177501949865 389 748649
SGTC_2651 TUB2.036 5 µM 1.62749492854464 0.0840142323409078 no 402 0.0518160124183324 582 15992207 YFL037W TUB2
SGTC_2131 toluylene red 5.2905 µM 1.62624351413259 0.0842070346468305 no 403 0.0519489313708369 376 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_497 capsazepine 133 µM 1.62518434130735 0.0843704781060437 no 404 0.052061642952944 330 2733484 A calcium channel blocker.
SGTC_3051 9093778 49.47 µM 1.61915597559334 0.0853052652207252 no 405 0.0527068537966015 268 17217378
SGTC_2926 9010726 65.15 µM 1.61881974014364 0.0853576310344164 no 406 0.0527430267714972 379 2994293
SGTC_1867 st057372 64 µM 1.61375124553618 0.0861499258327032 no 407 0.0532906967773101 350 688837
SGTC_1267 0828-0272 9.49 µM 1.61268900224306 0.0863166682139951 no 408 0.0534060455359882 401 745334
SGTC_2154 5570129 200 µM 1.61027101228426 0.0866971245630315 no 409 0.0536693523189145 398 673366
SGTC_899 1083-0020 478 µM 1.60794444473033 0.0870643778726696 no 410 0.0539236733298989 395 767123
SGTC_1024 4507-0395 26 µM 1.60597788580971 0.0873757082004589 no 411 0.0541393844664828 363 4201836
SGTC_724 3910-0327 137 µM 1.60291637240091 0.0878620359832234 no 412 0.0544765592486228 376 2885483
SGTC_3068 9116768 49.47 µM 1.60138516432123 0.0881060276504586 no 413 0.0546458182975075 352 41904888
SGTC_1810 st050138 53 µM 1.59728294455105 0.0887621883728939 no 414 0.0551013254248357 305 3444541
SGTC_545 4218-0007 221 µM 1.5825145760415 0.0911545666193723 no 415 0.0567660737354983 360 2840508
SGTC_2261 9010538 184.68 µM 1.57688926598153 0.0920782967295456 no 416 0.0574105034139978 311 6457250
SGTC_1218 1348-1416 30.7 µM 1.57140058118489 0.0929862541619615 no 417 0.0580448155390328 381 6787668
SGTC_2242 6630449 61.2675 µM 1.56728783183879 0.0936709249213684 no 418 0.0585237141481541 342 691249 YDR170C SEC7
SGTC_1699 st031318 29.054 µM 1.56642806620715 0.093814523783271 no 419 0.0586242183389569 385 5340658
SGTC_1280 0880-0253 10.1 µM 1.56592247792214 0.0938990434522206 no 420 0.0586833834284203 407 6836607
SGTC_3182 9108849 49.47 µM 1.56527270688293 0.0940077487952639 no 421 0.058759489925374 434 17133045
SGTC_1865 st057639 52.2 µM 1.56336010489025 0.0943282620564512 no 422 0.0589839591631465 399 688818
SGTC_470 aa-861 153 µM 1.56320911139814 0.094353599781799 no 423 0.0590017088668396 441 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_540 1187-0821 17.3 µM 1.56079614372095 0.0947591932585235 no 424 0.0592859288088424 368 847520
SGTC_908 3448-7491 47.7 µM 1.55848249449234 0.0951492976336847 no 425 0.0595594572738096 518 1203031
SGTC_1484 3473-2379 286 µM 1.55669950486543 0.0954507334683335 no 426 0.0597709231396481 457 671917
SGTC_806 3966-4455 5.86 µM 1.55631513488337 0.0955158078328544 no 427 0.0598165871076613 342 714982
SGTC_1665 st014639 11.4 µM 1.54948106327933 0.09667828211883 no 428 0.0606330601295946 437 981133 YIL048W NEO1
SGTC_532 1548-0774 215 µM 1.54939554116005 0.0966928949579871 no 429 0.0606433324916025 412 5932993
SGTC_1562 morin hydrate 59.1 µM 1.54694718160507 0.0971119250962336 no 430 0.060937991281785 393 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1476 4112-3294 3.34 µM 1.5466474656687 0.0971633120913676 no 431 0.0609741387040382 374 704369
SGTC_2979 9012552 45.46 µM 1.54472494811011 0.0974934067960814 no 432 0.061206403850134 315 17100905
SGTC_3082 9117008 49.47 µM 1.54115707441464 0.0981081860904734 no 433 0.0616392809314402 391 41448529
SGTC_737 1950-0117 57.9 µM 1.53947631424019 0.0983987795779914 no 434 0.0618440279832793 396 5393513
SGTC_500 h-89 112 µM 1.53896406121398 0.098487470292858 no 435 0.0619065351228527 423 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1168 k815-0004 80.5 µM 1.53691980551678 0.0988419925028621 no 436 0.0621564744130834 391 642433
SGTC_2842 9000675 19.48 µM 1.53499601682204 0.0991764749172042 no 437 0.0623924032268924 397 2989072
SGTC_1935 st074532 41.6 µM 1.53257887176575 0.0995979078779896 no 438 0.0626898252929493 490 2829742
SGTC_2202 7226349 200 µM 1.52573340021383 0.100798524499724 no 439 0.0635381364178644 329 844334
SGTC_1310 1188-0297 994 nM 1.52532605050097 0.100870300201094 no 440 0.0635888966424026 421 1588352
SGTC_1170 0310-0127 64.8 µM 1.5228224487669 0.101312257489192 no 441 0.0639015660169032 418 774975
SGTC_3028 9087778 49.47 µM 1.5217405198418 0.101503684830475 no 442 0.0640370552045423 385 17217395
SGTC_707 0865-0008 204 µM 1.51671993397785 0.102395432682249 no 443 0.064668704615837 402 723043
SGTC_86 0417-1630 471.922 µM 1.51627827196799 0.102474151707091 no 444 0.0647245017003234 562 3634867
SGTC_87 0100-0052 35.5 µM 1.51226495038205 0.103191477829017 no 445 0.0652332368677778 649 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2189 6047310 154.431 µM 1.50949415034149 0.103688843532233 no 446 0.0655862745324653 391 711535
SGTC_1150 3909-7983 10.9 µM 1.50643792062826 0.104239459258838 no 447 0.0659773961273202 454 23965914
SGTC_1995 st072814 61.1 µM 1.5039714218541 0.104685371006929 no 448 0.0662943626495294 384 5769371
SGTC_3109 9122853 49.47 µM 1.50054068204021 0.105307900203602 no 449 0.0667372018238209 408 1234709
SGTC_2368 9071271 200 µM 1.49608519947825 0.106120367169067 no 450 0.0673157271446824 423 27209959
SGTC_2731 amoxapine 43.43 µM 1.49493262047537 0.106331277782764 no 451 0.0674660139354306 246 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3276 9139060 49.47 µM 1.49445040215021 0.106419608752128 no 452 0.0675289681110127 330 4870619
SGTC_1462 k081-0014 26.5 µM 1.49392447094311 0.106516007277185 no 453 0.0675976807978591 287 3270634
SGTC_1569 carminic acid 40.6 µM 1.49202711521888 0.106864299667803 no 454 0.0678460185599542 425 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1790 st045711 43.5 µM 1.49116798397723 0.107022278016225 no 455 0.0679586985183776 414 585119
SGTC_848 0368-0089 85.6 µM 1.48902511885779 0.107417045179095 no 456 0.0682403771698653 439 762535
SGTC_961 1252-1571 372 µM 1.4881798491689 0.107573052447856 no 457 0.0683517349831753 438 6813498
SGTC_1991 st073000 8.92 µM 1.48761596923292 0.107677215741911 no 458 0.0684260997851485 502 4301969 YIL048W NEO1
SGTC_103 0844-0104 51.839 µM 1.48645942881021 0.107891086172102 no 459 0.068578820278346 558 5375804
SGTC_55 0767-0285 6.563 µM 1.48610367818914 0.107956933976292 no 460 0.0686258497766263 488 3116166
SGTC_3250 9135583 49.47 µM 1.48306878882721 0.108519854804226 no 461 0.0690280676982226 383 7699353
SGTC_3122 9126309 49.47 µM 1.48193510350512 0.108730675107672 no 462 0.0691787817693085 384 17591206
SGTC_1837 st055472 66.5 µM 1.48075339517692 0.108950739109731 no 463 0.0693361498540349 437 676091
SGTC_1135 dihydrocapsaicin 536.708 nM 1.48018831477568 0.109056084466583 no 464 0.0694114989954617 458 107982 A Capsaicinoid.
SGTC_2607 solasodine 47.35 µM 1.47728543953235 0.109598408295961 no 465 0.0697995696783926 460 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3146 9095609 49.47 µM 1.47626464999106 0.109789574686508 no 466 0.0699364300086453 412 17173999
SGTC_1816 st051957 91.6 µM 1.47299100425722 0.110404254603981 no 467 0.0703767307177033 410 674121
SGTC_692 k241-0027 77.8 µM 1.4681789103093 0.111312276267781 no 468 0.0710278156713338 415 3600480
SGTC_1121 fusaric acid 630.51 nM 1.4627510991362 0.112342882528867 no 469 0.0717677491350525 463 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1304 1165-0502 251 µM 1.46108911256574 0.112659811655088 no 470 0.0719954938418915 518 767425
SGTC_1108 betulinic acid 729.144 nM 1.46103050242901 0.112670999838786 no 471 0.0720035353870595 447 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_755 1995-0008 37.3 µM 1.45509304467511 0.113808525387622 no 472 0.0728217522262991 433 689533
SGTC_1756 st041558 35.5 µM 1.44774088328449 0.115228398012365 no 473 0.0738447657374296 478 3955792
SGTC_3356 9151811 4.48 µM 1.44419730486208 0.115917224283718 no 474 0.0743417414100075 448 1859254 YPR165W RHO1
SGTC_1977 st070720 65.3 µM 1.43355835581099 0.118002849805743 no 475 0.0758491673415085 415 682188
SGTC_633 0437-0093 97.7 µM 1.43233461239617 0.118244440084698 no 476 0.076024040959838 433 2831118
SGTC_1524 corynanthine 62.1 µM 1.43095622296989 0.118516979003479 no 477 0.0762213809862108 433 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_420 mitomycin C 81.9 mM 1.42966974727669 0.118771744739076 no 478 0.0764059134971499 472 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2010 4012422 159 µM 1.42722307529374 0.119257335588028 no 479 0.0767578026281245 467 952393
SGTC_575 k072-0246 11.9 µM 1.42618946916977 0.119462895773641 no 480 0.0769068292823221 469 6796779
SGTC_1898 st060199 18.6 µM 1.42559567802083 0.119581099997468 no 481 0.0769925422666056 433 688866
SGTC_1424 4048-1941 275 µM 1.42497747399619 0.119704251651844 no 482 0.0770818563434828 475 X1424
SGTC_741 4582-0002 126 µM 1.42346433943222 0.120006058609227 no 483 0.0773007963211542 480 2912688
SGTC_720 r052-1644 49.9 µM 1.4225195336962 0.120194779555228 no 484 0.0774377424755779 410 1422863 YOR257W CDC31
SGTC_1348 1493-0373 93.8 µM 1.4215564229483 0.120387371979993 no 485 0.0775775314428304 452 3010129
SGTC_1510 1123-0200 71.5 µM 1.42017306840795 0.120664380352771 no 486 0.0777786510698024 549 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_993 3909-8757 62.7 µM 1.41607695014267 0.121487233663702 no 487 0.0783764879507037 421 4288324 YLR208W SEC13
SGTC_2719 novobiocin 32.65 µM 1.4122005637535 0.122269571325262 no 488 0.0789454572837582 359 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2832 7992762 51.95 µM 1.4118432843377 0.122341855547812 no 489 0.0789980552086384 414 2985177
SGTC_3319 9138450 16.7555 µM 1.40400182520247 0.123935885080385 no 490 0.0801591530290037 453 2029690
SGTC_2046 4110841 106 µM 1.40297737457814 0.124145206398309 no 491 0.0803117929594967 469 44119630 YMR134W ERG29
SGTC_1469 k284-2957 126 µM 1.39894958111104 0.124970584368272 no 492 0.0809140514640126 441 23884841
SGTC_1574 spiramycin 23.7 µM 1.39824693889722 0.125114962037239 no 493 0.0810194628609225 490 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_327 1273-0057 3.96 µM 1.39592339090902 0.125593229900876 no 494 0.0813687829992873 453 3108138
SGTC_645 0845-0943 5.41 µM 1.39299772907283 0.126197246367208 no 495 0.0818102387013024 481 1885106
SGTC_1998 st075797 76.8 µM 1.39009782215868 0.126797940785739 no 496 0.0822495872707567 526 24208315
SGTC_591 4299-0174 154 µM 1.38783568292796 0.127267906422865 no 497 0.0825935432053015 478 5509088
SGTC_2844 9010103 25.97 µM 1.38579933394515 0.127691998694156 no 498 0.0829040929182083 506 2480525
SGTC_2770 toltrazuril 17.5 µM 1.38380470789324 0.128108353084716 no 499 0.0832091305553486 503 68591 Kills coccidiodes.
SGTC_263 alizarin 107.927 µM 1.38379374485335 0.12811064409109 no 500 0.0832108094588837 570 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3348 9149464 3.537 µM 1.38294968021954 0.128287118338167 no 501 0.0833401478191715 491 1951442
SGTC_681 1642-0006 26.6 µM 1.38286505475002 0.128304820857572 no 502 0.0833531235448045 428 4446530
SGTC_3014 9081533 49.47 µM 1.381151601599 0.128663617281546 no 503 0.0836161761595872 502 21367265
SGTC_3347 9188721 44.724 µM 1.37935452065122 0.129040672712462 no 504 0.0838927371188198 443 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2458 5808907 16.39 µM 1.37872838896514 0.129172224649595 no 505 0.083989256567099 498 2731747
SGTC_2082 5219693 150 µM 1.37695667923204 0.129544969218771 no 506 0.0842628209150775 510 2834649
SGTC_3181 9108277 49.47 µM 1.37685026834436 0.129567380375732 no 507 0.08427927276254 469 17097298
SGTC_984 1492-0255 2.91 µM 1.37421451122393 0.130123353510641 no 508 0.0846875485106334 457 1585198
SGTC_1505 k297-0037 20.6 µM 1.37285785623641 0.130410162053091 no 509 0.0848982701655942 514 4089396
SGTC_2486 5283202 22.39 µM 1.37065516302076 0.130876761085737 no 510 0.0852412390625948 480 1377751
SGTC_3130 9127414 49.47 µM 1.36969612195934 0.131080275945798 no 511 0.0853908898873736 459 1494646
SGTC_292 k038-0015 474 µM 1.3671080079484 0.131630581564652 no 512 0.0857957268047893 467 46368540
SGTC_1281 0884-0031 11.8 µM 1.36217730247226 0.132683395154717 no 513 0.0865709685480065 525 1548255
SGTC_2222 6885208 172.143 µM 1.35906817391591 0.133350236182645 no 514 0.0870624933748837 439 609514
SGTC_2852 9023854 51.95 µM 1.35820885390452 0.133534947776368 no 515 0.0871987109710758 529 19798528
SGTC_163 TUB2.036 7.546 µM 1.35803475566359 0.133572391772037 no 516 0.0872263280336926 683 15992207 YJR013W GPI14
SGTC_2118 5526350 200 µM 1.3579366893885 0.133593486451443 no 517 0.0872418870824402 515 743594
SGTC_932 2857-0803 154 µM 1.35635719801107 0.133933560694856 no 518 0.0874927723672632 549 674898
SGTC_646 4092-0839 27.3 µM 1.35308085172715 0.134640873880977 no 519 0.0880149010963212 505 877796
SGTC_2572 astragaloside iv 100 µM 1.35194032538985 0.134887696588243 no 520 0.0881972030137997 504 45006101 An anti-inflammatory agent.
SGTC_1233 0325-0408 14.2 µM 1.34734987958976 0.135884258303094 no 521 0.0889337872914668 506 12874
SGTC_886 0866-0150 153 µM 1.34676264394689 0.136012106869259 no 522 0.0890283447207761 533 271463
SGTC_387 norethindrone acetate 66.7 µM 1.34360498492762 0.136700980531194 no 523 0.0895380783385402 468 541197
SGTC_2468 5987765 72.9 µM 1.34265137707496 0.13690948741823 no 524 0.0896924429441434 516 26772094
SGTC_404 fumagillin 50 µM 1.34168893595096 0.137120145983328 no 525 0.0898484379554017 547 12015870 A methionine aminopeptidase binder.
SGTC_3165 9101544 49.47 µM 1.339829908268 0.137527675589738 no 526 0.0901503248863981 530 5002184
SGTC_662 k832-1615 104 µM 1.33970112217963 0.137555938221823 no 527 0.0901712662945002 513 5878478
SGTC_177 1327-0068 8.361 µM 1.33893292718362 0.137724604100052 no 528 0.0902962545831333 537 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1905 st060207 84.5 µM 1.33845673532319 0.137829228223676 no 529 0.0903737974101053 513 1948547
SGTC_2303 7774051 200 µM 1.3341866205207 0.138769838501952 no 530 0.0910713516277173 494 2953184
SGTC_1757 st041620 31.8375 µM 1.33248002446033 0.139146983229568 no 531 0.0913512506054842 529 5289815
SGTC_325 2810-4341 181 µM 1.33116856774867 0.13943727877706 no 532 0.0915667756969373 507 774970
SGTC_723 4182-0001 115 µM 1.32756075379553 0.140238005449625 no 533 0.0921616285070563 496 744821 YLR208W SEC13
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.32622443147289 0.140535383053718 no 534 0.0923826845222149 515 390807
SGTC_471 1-acyl-paf 4 µM 1.32522468700558 0.14075814025495 no 535 0.0925483198263587 517 16759367
SGTC_656 4090-1979 187 µM 1.32385693754599 0.141063282085833 no 536 0.0927752810726538 574 22330961
SGTC_358 0075-0058 9.45 µM 1.32360178785144 0.141120255020926 no 537 0.0928176655487916 634 1069125
SGTC_276 colchicine 750 µM 1.32315501206837 0.141220054142652 no 538 0.0928919166896901 560 2833 A microtubule depolymerizer.
SGTC_969 1313-0238 134 µM 1.32215483668526 0.1414436430426 no 539 0.0930582983187921 580 5212874
SGTC_524 r073-0010 27.8 µM 1.32069119660446 0.141771271527247 no 540 0.0933021753082943 515 2772106
SGTC_270 tamoxifen 5.46 µM 1.32021668373872 0.141877599088404 no 541 0.0933813416240081 573 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_19 0279-0214 38.434 µM 1.31805478895457 0.142362713954078 no 542 0.0937426538211075 640 3566274 YBR002C RER2
SGTC_2426 5582046 32.21 µM 1.31781292945289 0.142417055332768 no 543 0.0937831393106065 549 2251934
SGTC_1208 2323-2347 50.3 µM 1.3155043366148 0.142936459796223 no 544 0.0941702304271693 539 5412760
SGTC_3079 9117512 49.47 µM 1.31479837846035 0.143095546800618 no 545 0.0942888362877186 529 7185044
SGTC_443 clozapine 122 µM 1.31089924199237 0.143976367920259 no 546 0.0949459034999887 444 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2431 5490079 200 µM 1.31007574449287 0.144162864039861 no 547 0.0950851064952392 552 5722345
SGTC_1189 1431-2119 7.28 µM 1.30999567846088 0.144181005145752 no 548 0.0950986487716527 560 3107275
SGTC_1912 st060209 90.8 µM 1.30470030339388 0.14538423189248 no 549 0.0959974590720173 520 688787
SGTC_1446 4239-0190 62 µM 1.30170418556944 0.1460679999272 no 550 0.0965087641093753 599 1340085
SGTC_386 1509-0011 3.07 µM 1.30102532527802 0.146223227792472 no 551 0.0966248931180396 644 3107280
SGTC_1231 0242-0792 125 µM 1.29501872836456 0.147601519338879 no 552 0.0976568844379674 539 3707635
SGTC_1615 st002656 86.5 µM 1.29443706607615 0.147735449944059 no 553 0.0977572472089199 537 1584458
SGTC_3308 9128332 17.569 µM 1.29389384317137 0.147860603162444 no 554 0.0978510457314739 640 17332805 YDL196W YDL196W
SGTC_1702 st027038 51 µM 1.29384842895653 0.147871069365469 no 555 0.0978588904096828 584 5521182
SGTC_1710 st031758 61.5 µM 1.2920773563071 0.148279619296448 no 556 0.0981651783657551 516 5394341
SGTC_3290 9121031 71.43 µM 1.28600983709653 0.149684991120042 no 557 0.099219814287358 484 17014854
SGTC_3177 9107506 49.47 µM 1.28393763719607 0.150166987705302 no 558 0.0995818883944143 507 8897194
SGTC_2939 9044578 71.43 µM 1.28377574752265 0.150204686989379 no 559 0.0996102158795401 546 2653634
SGTC_3098 9119039 49.47 µM 1.28247102795558 0.150508747595421 no 560 0.0998387309367615 556 17161528
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.28206502863493 0.150603447988039 no 561 0.0999099177297393 526 2374 Ca(2+)-ATPase inhibitor.
SGTC_2033 5192550 145 µM 1.28138600448575 0.150761920798412 no 562 0.100029058772193 532 182073
SGTC_2720 fluspirilene 36.88 µM 1.28084709977363 0.150887771085077 no 563 0.100123688382584 483 3396 An atypical antipsychotic.
SGTC_2206 7254556 146.969 µM 1.28004107756597 0.15107613173172 no 564 0.100265344759922 500 4398905
SGTC_1433 4060-0023 7.6 µM 1.27724035798277 0.151731852393137 no 565 0.100758701384461 578 3840627
SGTC_883 0850-0245 24.6 µM 1.27622819144616 0.151969291262869 no 566 0.100937432885898 597 6823229 YPR165W RHO1
SGTC_95 0471-0001 561.058 µM 1.27571030571344 0.152090874774154 no 567 0.101028972089655 571 4015405
SGTC_585 0kpi-0023 191 µM 1.27502910894648 0.152250896993931 no 568 0.10114946955719 519 64601
SGTC_1962 st076595 64.5 µM 1.27338137965241 0.152638432654627 no 569 0.101441370780501 560 279619
SGTC_1096 rimcazole 32.2 µM 1.27209822791798 0.152940674781053 no 570 0.101669110370759 514 18528119 A dopamine reuptake inhibitor.
SGTC_1694 st024011 44.9 µM 1.270331040136 0.153357579114389 no 571 0.101983367948959 614 2787533
SGTC_435 c-PAF 6.7 µM 1.27014687130706 0.153401070397404 no 572 0.102016159170738 596 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1666 st014829 29 µM 1.26727646052366 0.154079970958018 no 573 0.102528227186284 596 3858230
SGTC_3161 9100388 49.47 µM 1.26697578411227 0.154151200835754 no 574 0.102581974398796 563 25236368
SGTC_3031 9088762 49.47 µM 1.2665580654578 0.15425019402309 no 575 0.10265667740842 575 205253
SGTC_2080 5212524 12.4 µM 1.26294061477286 0.155109234943726 no 576 0.103305261180158 547 260183
SGTC_1907 st060210 83.7 µM 1.26097963168371 0.155576229981723 no 577 0.103658092850273 630 688793
SGTC_1809 st050081 57.6 µM 1.25635182571086 0.156681984414781 no 578 0.104494219789434 580 5036894
SGTC_1969 st069479 40.1 µM 1.25181198839997 0.157771734140439 no 579 0.105319190348408 514 3895485
SGTC_1439 4092-1168 46 µM 1.25084004141067 0.158005687284865 no 580 0.105496421417539 579 2886240
SGTC_1028 k015-0029 4.8 µM 1.24815416885728 0.158653375729599 no 581 0.105987302083353 609 4588309
SGTC_1178 0988-0033 191 µM 1.24600486264366 0.159172925277147 no 582 0.106381304992173 605 5392207
SGTC_1290 0986-0249 10.2 µM 1.24587760090665 0.159203723031411 no 583 0.106404667268008 535 53329
SGTC_2921 7974240 10.71 µM 1.24582461460667 0.159216547039066 no 584 0.106414395404585 581 2979074 YDR527W RBA50
SGTC_2551 apiole 73.87 µM 1.24550051381596 0.159295002248308 no 585 0.106473913381927 421 10659 A possible DNA adduct former.
SGTC_956 1185-0240 191 µM 1.24405936604202 0.159644167985945 no 586 0.106738857281868 583 1416193
SGTC_1247 0448-0043 5.84 µM 1.24185528178864 0.160179148354246 no 587 0.107144980870832 630 3089013 YGL099W LSG1
SGTC_2382 9035899 200 µM 1.24112176341297 0.160357449226004 no 588 0.107280385459871 601 6462679
SGTC_2238 6671620 73.2395 µM 1.23851001598099 0.160993355542916 no 589 0.107763505276164 567 729941
SGTC_531 3788-1495 174 µM 1.23704835068913 0.161349958031826 no 590 0.108034566451967 588 2896655
SGTC_3189 9110682 49.47 µM 1.23452246412435 0.161967411988062 no 591 0.108504140599644 582 17122418
SGTC_1587 estradiol valerate 56.1 µM 1.23051844172289 0.162949346434194 no 592 0.109251512720846 616 13791 A steroid.
SGTC_2219 9098279 200 µM 1.23046319518648 0.162962921942369 no 593 0.109261850585027 561 902349
SGTC_1145 3546-0597 10.2 µM 1.22688218368333 0.163844437789563 no 594 0.109933437896798 622 875334
SGTC_2502 avocadyne acetate 18.59 µM 1.22649516621781 0.163939892483594 no 595 0.110006196615232 663 3952079
SGTC_1669 st015249 58.4 µM 1.22604247217742 0.164051591547355 no 596 0.110091346269974 590 722793
SGTC_2199 6590217 200 µM 1.22420063360662 0.164506561169918 no 597 0.110438275115531 525 703109
SGTC_2348 9022543 33.42 µM 1.22280233541522 0.164852513348233 no 598 0.110702181586727 618 3162678 YDL140C RPO21
SGTC_2231 micatex 6.853 µM 1.22122410401227 0.16524354834154 no 599 0.111000590129721 567 20737 An antifungal of unknown mechanism.
SGTC_1682 st012968 530 nM 1.22063632158885 0.165389335214238 no 600 0.111111873856017 555 24207270
SGTC_1375 2910-0797 186 µM 1.21967752667678 0.165627322335524 no 601 0.111293572083786 612 742508
SGTC_1316 1272-0050 65.9 µM 1.21831163741502 0.165966738576832 no 602 0.111552784684812 606 7340392
SGTC_1627 st003713 25.6 µM 1.21820920048496 0.165992211717746 no 603 0.111572242125188 682 16195070 YER133W GLC7
SGTC_483 fpl-64176 144 µM 1.21797171953474 0.166051276169664 no 604 0.111617359918287 537 3423
SGTC_2373 9071805 200 µM 1.21520021103953 0.166741588460098 no 605 0.112144869985028 611 10149009
SGTC_90 0870-0863 4.608 µM 1.21500987246836 0.166789064812734 no 606 0.112181163017363 647 1738164
SGTC_125 0133-0007 11.75 µM 1.21374455327797 0.167104896397706 no 607 0.112422642662561 651 26541
SGTC_2339 9000433 200 µM 1.21212959948993 0.167508558738984 no 608 0.112731387437152 547 2988954
SGTC_226 1,3-diallylurea 8.28947 mM 1.21137652081391 0.167697007508574 no 609 0.112875566849657 549 74537 YKL182W FAS1
SGTC_3245 9134821 49.47 µM 1.21077202939435 0.167848372868399 no 610 0.112991393942445 618 17014901
SGTC_3070 9117005 49.47 µM 1.20855657946186 0.168403875772031 no 611 0.113416623215078 536 8779016
SGTC_1622 st003707 19.4 µM 1.20778022546864 0.168598818541627 no 612 0.113565904840728 648 10140899
SGTC_1691 st019933 84.6 µM 1.2076103433824 0.168641495331764 no 613 0.113598589378118 585 6176082
SGTC_49 0717-0965 32.132 µM 1.20694814121433 0.168807916189222 no 614 0.113726058071182 623 5889349 YGL099W LSG1
SGTC_162 k030-0015 37.8 µM 1.20676102952079 0.16885495914358 no 615 0.113762094062669 629 1809920 YMR134W ERG29
SGTC_10 0279-0212 42.575 µM 1.20594196622641 0.169060984237048 no 616 0.113919933906878 721 39851 YBR002C RER2
SGTC_3326 9140064 16.379 µM 1.20593956656299 0.169061588079354 no 617 0.113920396569756 591 1868434
SGTC_1716 st033144 30.6155 µM 1.20355763820774 0.169661650605367 no 618 0.114380300512676 642 674617
SGTC_2514 salinomycin 42.74 µM 1.20162651036091 0.170149147658346 no 619 0.114754132765666 684 23682228 A polyether potassium ionophore.
SGTC_702 1488-0190 94 µM 1.19890742876495 0.170837077138763 no 620 0.115281971419506 622 949357
SGTC_391 gliotoxin 8.33 µM 1.19561455067447 0.171672556859733 no 621 0.115923505292044 656 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_903 1134-0042 114 µM 1.19458420999383 0.171934513481568 no 622 0.116124760743868 606 701009
SGTC_2729 fluphenazine 10.66 µM 1.1934658242535 0.172219143619845 no 623 0.116343494494479 630 3372 An atypical antipsychotic.
SGTC_2671 danthron 100 µM 1.19337406330064 0.172242510201081 no 624 0.116361454057697 610 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3306 9127676 59.7925 µM 1.19102622874127 0.172841065398779 no 625 0.116821644168156 593 41905287
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.19063651625966 0.172940546535984 no 626 0.116898154901122 734 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.190510622821 0.17297269090081 no 627 0.116922878657521 647 688669
SGTC_854 0422-0053 192 µM 1.18791335405122 0.173636700618312 no 628 0.11743377397202 613 3596728
SGTC_233 rapamycin 362 pM 1.18759831536327 0.173717352585735 no 629 0.117495850935224 639 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3192 9110362 49.47 µM 1.18748696720146 0.173745864143592 no 630 0.117517797148088 653 16649480
SGTC_1013 4112-3890 241 µM 1.18737450411719 0.173774664207356 no 631 0.117539966052812 647 705171
SGTC_1171 0368-0077 21.4 µM 1.18498675160547 0.174386847380145 no 632 0.118011342560172 593 3239779
SGTC_2432 5630864 12.22 µM 1.18488100236205 0.174413991511576 no 633 0.118032249851887 619 5714970
SGTC_2964 9083345 53.42 µM 1.18468217418327 0.174465034776795 no 634 0.118071566529282 578 17741579
SGTC_1550 gossypolone 36.6 µM 1.182989860702 0.174899870307955 no 635 0.118406582918019 653 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2170 morpholine 200 µM 1.18279640406581 0.17494962225429 no 636 0.11844492303432 650 121171 Reacts with secondary amines.
SGTC_2460 5552655 174.22 µM 1.18244720368779 0.175039450117383 no 637 0.118514151366946 615 5401989
SGTC_751 0833-0568 350 µM 1.18126978681779 0.175342542955016 no 638 0.118747782837796 636 6954252
SGTC_588 3970-1144 52.9 µM 1.181206487244 0.175358847068987 no 639 0.118760352401273 659 1888707
SGTC_3052 9092717 49.47 µM 1.1796541956049 0.175758972642821 no 640 0.119068889226756 597 25237534
SGTC_1298 1079-1278 263 µM 1.17937544325271 0.175830886292428 no 641 0.119124354528117 675 2840950
SGTC_472 calcifediol 10 µM 1.17632684620871 0.176618591730069 no 642 0.119732145930808 565 5283731 A vitamin D metabolite.
SGTC_2019 4016004 108 µM 1.17594143712206 0.176718333506558 no 643 0.11980913943387 576 45595336
SGTC_2965 9082772 38.63 µM 1.17508847723207 0.176939201478474 no 644 0.119979660065358 680 16459634
SGTC_193 1273-0060 1.558 µM 1.17327633546052 0.177409021565793 no 645 0.120342504461223 534 2847393 YHR072W ERG7
SGTC_1078 idebenone 36.1 µM 1.17121545607904 0.177944286143261 no 646 0.120756092071876 694 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2401 5128683 200 µM 1.17094759390257 0.178013931706439 no 647 0.120809921380033 590 708373
SGTC_1884 5633444 25 µM 1.17069150791618 0.178080531466952 no 648 0.120861399946187 661 5724239
SGTC_2317 5986382 200 µM 1.16819805759542 0.178729818894435 no 649 0.121363441911961 666 877883
SGTC_2752 diclazuril 33.15 µM 1.16706888534485 0.179024341843242 no 650 0.121591275992229 817 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2101 5377231 179.231 µM 1.1662941212709 0.17922660075011 no 651 0.121747774609255 635 2844213
SGTC_1119 parthenolide 318.541 nM 1.16608548076684 0.179281092723115 no 652 0.121789943165729 721 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1014 4130-3005 69.3 µM 1.16411804833463 0.179795451856104 no 653 0.12218808770419 663 743608
SGTC_1651 st011928 86.1 µM 1.16137083415124 0.180515223825779 no 654 0.122745562287958 651 720198
SGTC_2877 9040724 71.43 µM 1.16014975234726 0.180835727472719 no 655 0.122993920405914 639 6463895
SGTC_1650 st011916 45.8 µM 1.1598087195367 0.180925303797927 no 656 0.123063346600914 631 242528
SGTC_354 2783-3500 4.88 µM 1.15827012149362 0.181329780520209 no 657 0.123376910207293 639 6740761
SGTC_1893 st059353 36.1 µM 1.15809469587801 0.181375933486032 no 658 0.123412697158363 644 3112488
SGTC_1085 doxorubicin 7.67 µM 1.15591737271865 0.181949380439871 no 659 0.123857477944214 710 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_61 0978-8327 98.565 µM 1.15450804308398 0.182321162809127 no 660 0.124145971494058 689 6150059 YHR072W ERG7
SGTC_1065 prochlorperazine maleate 2.48 µM 1.15354421581492 0.182575694394851 no 661 0.124343540006573 673 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1037 k284-1091 78.7 µM 1.1532943343691 0.182641720353203 no 662 0.124394797408951 605 3334711
SGTC_3129 9127257 49.47 µM 1.15273615852932 0.18278926051468 no 663 0.124509347640422 559 837894
SGTC_3312 9133330 71.43 µM 1.14882423290937 0.183825369373109 no 664 0.125314232440604 709 17617324
SGTC_2072 5231554 129 µM 1.14794320978521 0.184059220045477 no 665 0.125496004369735 671 789545
SGTC_593 1203-0218 61.7 µM 1.14776950372366 0.184105348832643 no 666 0.125531864960011 699 3666956
SGTC_2806 7952793 58.44 µM 1.14670925507667 0.184387060827395 no 667 0.12575090205895 660 2972490
SGTC_3005 9076496 71.4286 µM 1.14636131996194 0.184479566889469 no 668 0.125822840149529 632 21368410
SGTC_523 1934-0222 13.7 µM 1.14553100014853 0.184700441956028 no 669 0.125994630719567 678 1361595
SGTC_1711 st032263 62.8 µM 1.14422595317462 0.185047932287237 no 670 0.126264971264052 623 3958979
SGTC_1631 benzylvanillin 81.9 µM 1.14134702800266 0.185815928744101 no 671 0.126862769554563 683 75506
SGTC_2234 tolnaftate 200 µM 1.14061174678132 0.186012392519267 no 672 0.127015763375183 605 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1610 st001799 48.1 µM 1.13877911735847 0.186502622933685 no 673 0.127397646928289 594 621897
SGTC_2377 9073351 62.6 µM 1.13798407299119 0.186715546821847 no 674 0.127563566484121 657 7337946 YHR072W ERG7
SGTC_2950 9072895 21.46 µM 1.13699574096046 0.186980445533079 no 675 0.127770033060031 674 17332245
SGTC_2099 5377090 177.372 µM 1.13637252514756 0.187147603068218 no 676 0.127900344715387 663 2243829
SGTC_37 0566-0070 1.56 µM 1.13595644696367 0.187259254049738 no 677 0.127987396205491 715 1626686
SGTC_544 k015-0020 52.4 µM 1.13589795585368 0.187274952934383 no 678 0.127999636960269 659 3008304
SGTC_44 0929-0055 61.211 µM 1.13535028676037 0.187421985586777 no 679 0.128114290130259 621 1379590
SGTC_1800 st050079 29.0735 µM 1.13414689200302 0.187745311378247 no 680 0.128366468362888 812 3645560
SGTC_446 go6976 132 µM 1.13380848242371 0.187836296641958 no 681 0.12843744606022 636 3501 A protein kinase C inhibitor.
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.13332700611365 0.187965793944881 no 682 0.128538477381844 750 688761
SGTC_2734 clemastine 41.6 µM 1.13303098101163 0.188045439863646 no 683 0.128600621638766 544 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1207 2099-0101 141 µM 1.13289354722306 0.188082423673659 no 684 0.128629480063952 724 5837381
SGTC_3264 9137442 49.47 µM 1.13171609229403 0.188399464000781 no 685 0.128876906900648 638 17015726
SGTC_594 1487-1584 10.8 µM 1.13124054732811 0.188527602152611 no 686 0.128976930016559 669 5013332
SGTC_2402 5553605 200 µM 1.13095073870892 0.188605718994226 no 687 0.129037912920538 707 6758546
SGTC_367 0335-0881 7.1 µM 1.128160272282 0.189358899655635 no 688 0.129626119243217 700 23828853
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.12627425165322 0.189869006432398 no 689 0.130024726466818 920 16725076
SGTC_2404 5161160 200 µM 1.12438677479248 0.190380352068743 no 690 0.130424490056336 716 2831543
SGTC_166 k072-0058 166.424 µM 1.1241602393863 0.190441780685952 no 691 0.130472526850356 686 5846229
SGTC_2931 9014674 55.67 µM 1.1222164740154 0.190969363191072 no 692 0.130885204900522 656 2996810
SGTC_17 0960-0276 49.807 µM 1.1171811824815 0.192340220352959 no 693 0.131958432362173 732 6821114
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.11151188675177 0.193890866853817 no 694 0.133174038208013 651 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3030 9087619 49.47 µM 1.11138614405376 0.193925345713986 no 695 0.133201086929784 662 25236973
SGTC_24 0417-1663 219 µM 1.11057188444549 0.194148707501857 no 696 0.133376335178436 678 4329390
SGTC_1058 3448-5425 97.3 µM 1.10807973169144 0.194833309949347 no 697 0.13391369172166 667 7279705
SGTC_2943 9068529 45.32 µM 1.10652509801556 0.195261115527486 no 698 0.134249653496874 742 3270634
SGTC_2027 5150920 200 µM 1.1058989506664 0.195433580468024 no 699 0.134385129520127 699 786715
SGTC_3350 9150499 3.57 µM 1.10459269030748 0.195793672287476 no 700 0.134668059930214 767 4910996 YPR165W RHO1
SGTC_2316 5844804 197.44 µM 1.10220381894301 0.196453244056515 no 701 0.135186536047427 844 776813
SGTC_312 4092-0653 6.84 µM 1.10205839507578 0.196493439286288 no 702 0.135218142701767 797 1148278
SGTC_905 2-aminofluorene 215 µM 1.10152186887309 0.196641778502933 no 703 0.135334795982522 761 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.10100604294031 0.196784458435127 no 704 0.135447013565054 675 75037 A free radical scavenger.
SGTC_1964 st076914 61 µM 1.0998904684904 0.197093246024274 no 705 0.135689924061697 716 24208661
SGTC_2863 9028737 58.44 µM 1.09755063563024 0.19774185636159 no 706 0.136200379256676 679 6460917
SGTC_1440 4100-1550 40 µM 1.09711983231756 0.197861417087068 no 707 0.136294505867096 697 742806
SGTC_3235 9132602 49.47 µM 1.09381592470706 0.198779800649809 no 708 0.13701785918989 730 4912240
SGTC_99 0109-0120 622.8 µM 1.08964530453673 0.199942765881126 no 709 0.137934709081744 677 759414
SGTC_2425 5628681 7.85 µM 1.08878776161798 0.200182395334814 no 710 0.13812374487385 806 5714958
SGTC_1681 tripelennamine 100 µM 1.08801290714027 0.200399066925743 no 711 0.138294704781102 635 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2204 7233102 200 µM 1.08596016177876 0.200973754109221 no 712 0.138748308981526 657 2172480
SGTC_557 1315-0110 16.2 µM 1.08501736992185 0.201238029376621 no 713 0.138956981072441 723 6833801
SGTC_1133 3473-0247 50 µM 1.08472566967949 0.201319838455061 no 714 0.139021587575218 705 711311
SGTC_1785 bathophenanthroline 24 µM 1.08122281248754 0.202303792002444 no 715 0.139799006379448 709 72812 An iron chelator.
SGTC_1750 st081859 2.357 µM 1.08026434537001 0.202573526057161 no 716 0.140012241068833 878 5291695
SGTC_3281 9140613 49.47 µM 1.07895390765912 0.202942660182154 no 717 0.140304137787486 660 16013766
SGTC_2168 5727979 200 µM 1.07879665369763 0.202986983662744 no 718 0.140339193466236 649 695210
SGTC_2228 7354201 200 µM 1.07726502912918 0.203418988466688 no 719 0.140680940397344 723 753451
SGTC_1862 st057513 3.81 µM 1.07639353042973 0.203665045079817 no 720 0.140875647267108 711 5393163
SGTC_3138 9097216 49.47 µM 1.07495365644444 0.204071963855894 no 721 0.141197738719572 724 25237486
SGTC_378 3970-0959 8.33 µM 1.07238745036526 0.204798391860366 no 722 0.141773021167219 736 6615653
SGTC_1256 0570-0116 285 µM 1.07222847343977 0.204843444734414 no 723 0.141808712159981 685 410638
SGTC_727 3032-0951 202 µM 1.06965227938203 0.205574340157869 no 724 0.14238792689432 706 3652836
SGTC_987 1497-1013 404 µM 1.06944202272359 0.205634060610018 no 725 0.142435270173973 712 1676435
SGTC_573 3702-0553 84.7 µM 1.06882808429128 0.205808500129449 no 726 0.142573571003646 711 1222756
SGTC_1945 st075991 56.6 µM 1.06865089968159 0.20585886025862 no 727 0.142613501949068 671 1084980
SGTC_1838 st055369 84.5 µM 1.06647276315078 0.206478536188779 no 728 0.143104992321031 698 676036
SGTC_1897 st060201 15 µM 1.0651666867815 0.206850641975658 no 729 0.143400252939049 689 611878
SGTC_1957 st077035 62.4 µM 1.06502981345718 0.206889660636335 no 730 0.143431219259717 757 705593
SGTC_2055 5235184 200 µM 1.06184571946232 0.207798583352991 no 731 0.144152865212164 729 2836034
SGTC_1939 st074455 53.6 µM 1.06159245805324 0.207870979773098 no 732 0.14421036952485 758 1644229
SGTC_2884 9058502 51.95 µM 1.0604927105203 0.208185522474557 no 733 0.144460252249708 734 6471554
SGTC_1314 1222-0010 41.1 µM 1.06019532714272 0.208270626369014 no 734 0.144527873270159 743 3526027
SGTC_1984 st072354 53.1 µM 1.05958345161459 0.208445794820462 no 735 0.144667072690861 736 5762938
SGTC_1608 st001473 40.5 µM 1.05938789439488 0.208501797489615 no 736 0.144711580272202 720 7292267
SGTC_1080 nisoldipine 24.4 µM 1.05885301972137 0.208655017455099 no 737 0.14483336145629 759 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1674 st016616 23.6 µM 1.05749456469731 0.209044458100209 no 738 0.1451429669574 733 625830
SGTC_962 1254-0300 21.5 µM 1.05693531078866 0.209204908806642 no 739 0.145270555853438 747 7340576
SGTC_3256 9138902 49.47 µM 1.05605923262243 0.209456402512193 no 740 0.145470577090409 779 17228773
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.05446553973563 0.20991435602616 no 741 0.145834914832201 820 5024745
SGTC_1564 D-Arginine 115 µM 1.05349159910519 0.210194510913808 no 742 0.146057871269999 709 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1054 3429-0080 167 µM 1.05222944182649 0.21055789808456 no 743 0.146347147341863 768 1162877
SGTC_3248 9135562 49.47 µM 1.05178380124822 0.210686290287817 no 744 0.146449376327116 790 17650701
SGTC_1198 1612-1005 86.7 µM 1.05175745463014 0.210693882372566 no 745 0.146455421684849 775 6998509
SGTC_1327 1436-0082 2.18 µM 1.05045381665612 0.211069741234526 no 746 0.146754756886807 748 15992205
SGTC_2083 5306046 65.942 µM 1.04999224982305 0.211202912194229 no 747 0.146860838010412 740 539837
SGTC_560 2332-1943 155 µM 1.04901137919355 0.2114860757686 no 748 0.147086440604068 754 21177716
SGTC_1325 1431-0015 227 µM 1.04831038723239 0.211688578438388 no 749 0.147247812734036 716 1103340
SGTC_192 3455-0609 60.9 µM 1.0466824426074 0.212159296917055 no 750 0.147623032028298 747 3769639
SGTC_616 4092-0450 108 µM 1.04634708286388 0.212256341793941 no 751 0.147700407413534 795 787165
SGTC_599 1935-0052 86.5 µM 1.04520823897988 0.21258608885398 no 752 0.147963368195691 772 9557311
SGTC_1243 0416-0003 5.65 µM 1.04378591956426 0.212998334840909 no 753 0.148292223749932 718 2141977
SGTC_3077 9117319 49.47 µM 1.04063952720252 0.213911942705142 no 754 0.149021439480884 719 17154678
SGTC_2417 cerulenin 830 nM 1.03984676336459 0.214142494332712 no 755 0.149205549578846 743 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1228 0124-0032 52.5 µM 1.03879683729739 0.214448056341127 no 756 0.149449616290572 793 X1228
SGTC_526 4469-0568 170 µM 1.0384850565296 0.214538843297023 no 757 0.149522144402127 740 2901964
SGTC_1755 st041960 45.185 µM 1.03578271051516 0.215326670821646 no 758 0.150151762670548 767 2257073
SGTC_2593 nobiletin 86.24 µM 1.03556845292959 0.215389206076729 no 759 0.150201757944186 705 72344 An anti-infammatory.
SGTC_3194 9111903 49.47 µM 1.03530660468103 0.215465645900321 no 760 0.150262873177997 744 17087251
SGTC_1659 st012954 42.1 µM 1.03518218816919 0.215501971596974 no 761 0.150291917728922 742 24207262
SGTC_925 2064-1272 59.6 µM 1.03444369045101 0.215717662738332 no 762 0.150464394155718 723 6815817
SGTC_698 k064-0052 127 µM 1.03286540727786 0.216179047170506 no 763 0.15083344467625 767 5088751
SGTC_2063 5246145 200 µM 1.03193790430178 0.216450453372168 no 764 0.151050603910516 783 711240
SGTC_1768 st044301 37.178 µM 1.0298991406989 0.217047729592971 no 765 0.151528677084171 789 3931349
SGTC_2556 citropten 84.59 µM 1.02888520871091 0.21734512537827 no 766 0.151766809872821 838 2775 A potential DNA crosslinker.
SGTC_1690 st023502 41.2 µM 1.02411566243591 0.21874723113321 no 767 0.152890323706303 759 24207482
SGTC_790 1575-0012 79.1 µM 1.02319891725071 0.219017322320554 no 768 0.153106902386393 804 378741 YLR208W SEC13
SGTC_2439 5492030 7.2 µM 1.02264027379502 0.21918200368979 no 769 0.153238980122926 757 5722370
SGTC_2406 ethylparaben 405.7 µM 1.02257769206382 0.219200456464089 no 770 0.153253780761139 665 8434 A possible steroid mimic.
SGTC_399 oxolinic acid 75 µM 1.02211947253032 0.219335593732465 no 771 0.153362178968911 758 4628 A DNA gyrase inhibitor.
SGTC_2241 6772625 37.8075 µM 1.02059560194697 0.219785355079285 no 772 0.153723037021582 737 2285411
SGTC_1395 3486-0190 4.35 µM 1.01910256959829 0.22022652771866 no 773 0.154077137197476 832 6748079
SGTC_2721 ifenprodil 61.44 µM 1.01805308439536 0.220536941339713 no 774 0.154326364692423 775 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_442 cape 100 µM 1.01760536993033 0.2206694412475 no 775 0.154432767181865 757 5281787
SGTC_1126 isoteolin 1.0172 µM 1.01736904606264 0.220739399052172 no 776 0.154488950761823 743 133323
SGTC_1407 3909-7909 12.3 µM 1.01657546540914 0.220974411791381 no 777 0.154677715290964 816 4411780
SGTC_832 4083-0019 164 µM 1.0139352660951 0.221757316309033 no 778 0.155306821085843 956 1990758
SGTC_1330 1469-0054 61.8 µM 1.01300675421343 0.222033026305933 no 779 0.15552846739312 846 7102664
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.01169462989382 0.2224229786985 no 780 0.155842041973441 846 66535 A nucleotide analog.
SGTC_637 1181-0519 7.26 µM 1.01120322325722 0.222569121125907 no 781 0.155959586706379 879 6252091 YGR060W ERG25
SGTC_322 k048-0136 19.3 µM 1.0100350263089 0.22291675804734 no 782 0.156239254578924 742 6823282
SGTC_2134 5324836 1.464 µM 1.00928212618331 0.223140973027885 no 783 0.156419674825087 725 699272
SGTC_1040 k898-0338 155 µM 1.00917449161302 0.223173037278798 no 784 0.156445478900945 854 20969351
SGTC_2112 5488546 200 µM 1.00798628898284 0.22352717613537 no 785 0.156730522262775 793 600757
SGTC_2496 diffractaic acid 79.83 µM 1.00720723702847 0.223759542720485 no 786 0.156917598007357 833 94870 An apoptosis inducer which activates caspases.
SGTC_2785 7756463 72.73 µM 1.00626998602296 0.224039276973757 no 787 0.157142857103875 782 2201551
SGTC_2044 5102272 200 µM 1.0062368779638 0.224049162118451 no 788 0.157150818188213 727 592666
SGTC_2446 5162541 200 µM 1.00590489776895 0.22414829585874 no 789 0.157230660011157 750 1549321
SGTC_1720 st037298 9.481 µM 1.00575058744316 0.224194383471665 no 790 0.15726778099531 767 597396
SGTC_1961 st076550 68.7 µM 1.00492595560783 0.224440766111655 no 791 0.157466252586713 728 1579337
SGTC_978 1416-0512 87.4 µM 1.00312285923832 0.22498002834273 no 792 0.157900793296551 824 6814003
SGTC_965 1291-5240 308 µM 1.0022881930608 0.225229905106775 no 793 0.158102211656627 818 2834598
SGTC_3081 9117243 49.47 µM 0.999283932391649 0.226130600501566 no 794 0.158828583365035 800 45595589
SGTC_1482 3346-2049 8.48 µM 0.998628789337182 0.226327286323639 no 795 0.158987274247874 781 3826804
SGTC_2107 5363541 170.161 µM 0.997952615229479 0.226530387345479 no 796 0.159151168251949 839 244052
SGTC_2293 7624732 200 µM 0.99728708922226 0.226730390459252 no 797 0.159312589355149 742 894453
SGTC_400 oxethazaine 37.5 µM 0.996902610639665 0.226845978917282 no 798 0.159405892189129 774 4621 A local anesthetic.
SGTC_1161 k007-0610 110 µM 0.996505391331426 0.22696543261285 no 799 0.159502324428192 891 5843850
SGTC_3222 9128301 49.47 µM 0.996371256067825 0.227005778423333 no 800 0.15953489683526 817 4911358
SGTC_362 0310-0100 9.03 µM 0.995433321861304 0.227288007493221 no 801 0.159762779435738 768 790235
SGTC_1965 Pectolinarigenin 58.4 µM 0.994557331182275 0.227551775919088 no 802 0.159975804337185 807 5320438 An anti-inflammatory.
SGTC_1049 3226-0134 66 µM 0.993741817190118 0.227797489144555 no 803 0.160174289302986 835 5702385
SGTC_1393 3470-5649 58.2 µM 0.993227651382964 0.227952483299535 no 804 0.160299512948588 693 4108395
SGTC_1374 2889-5571 141 µM 0.992496905596169 0.22817286705312 no 805 0.160477594099935 830 2853281
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.991381969834507 0.22850934838729 no 806 0.160749550459675 825 23665772 A membrane-active detergent.
SGTC_1721 st082152 9.2685 µM 0.991079010135152 0.228600828057755 no 807 0.160823500690892 756 5296051
SGTC_3006 9075424 71.4286 µM 0.987995774491139 0.229532990082678 no 808 0.161577358819132 771 7465181
SGTC_785 1270-0111 65.3 µM 0.987661014060563 0.229634327020723 no 809 0.161659346921348 801 6741994
SGTC_3075 9116269 49.47 µM 0.987124436225961 0.229796809341285 no 810 0.161790819841457 802 17015205 YNL244C SUI1
SGTC_3053 9095903 49.47 µM 0.986413104234464 0.230012308556601 no 811 0.161965218604728 841 17174018
SGTC_712 r015-0009 80.6 µM 0.986091026574832 0.23010991970598 no 812 0.16204422332444 773 6813872 YLR060W FRS1
SGTC_2568 diosmetin 100 µM 0.983309926569628 0.230953743087209 no 813 0.162727463029079 848 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2489 cantharidin 73.42 µM 0.983117304020806 0.231012251275212 no 814 0.162774854369882 807 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2497 7-hydroxyflavone 100 µM 0.982860541558395 0.231090254521816 no 815 0.16283804014776 752 5281894
SGTC_2773 thioridazine 9.09 µM 0.979162220570798 0.232215416547497 no 816 0.163749916123189 850 5452 An antipsychotic.
SGTC_2684 capsaicin 100 µM 0.979050310005418 0.232249511213966 no 817 0.163777560904146 792 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2224 6650123 117.647 µM 0.978329258779271 0.23246925341718 no 818 0.163955751689184 802 2908370
SGTC_115 0527-0192 112.043 µM 0.978162242432852 0.232520168562878 no 819 0.163997043772025 902 4233931
SGTC_3263 9137018 49.47 µM 0.977769627494067 0.232639882143887 no 820 0.164094138017881 768 43844957
SGTC_82 0054-0107 293.755 µM 0.977586504307322 0.23269573058378 no 821 0.164139437397817 824 3104697
SGTC_2386 9075165 157.42 µM 0.97316125782992 0.23404759441835 no 822 0.165236581245767 824 16452277
SGTC_1244 0416-0015 52.5 µM 0.971838710553755 0.234452460644641 no 823 0.165565397226066 810 96201
SGTC_1689 st020265 53.493 µM 0.971546664982508 0.234541915615607 no 824 0.165638063544569 850 5758320 YPR016C TIF6
SGTC_1900 st060200 72.8 µM 0.970557882578305 0.234844924574586 no 825 0.165884243919015 830 688945
SGTC_422 cantharidin 155 µM 0.96957179254693 0.235147323826548 no 826 0.166129989365552 821 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_960 1222-0186 7.7 µM 0.968132511745187 0.235589086557314 no 827 0.16648909731557 839 3126296
SGTC_810 3825-7150 143 µM 0.968122729258223 0.235592090690717 no 828 0.166491539809609 893 22330411 YGL099W LSG1
SGTC_247 mechlorethamine 29.705 µM 0.967534623247537 0.235772732755766 no 829 0.166638420777207 786 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_843 0310-0051 143 µM 0.96726065180898 0.23585691162287 no 830 0.166706874383413 830 2065037
SGTC_2576 guaiol 23.12 µM 0.966549757816501 0.236075414017341 no 831 0.166884580641235 894 227829
SGTC_2776 terbinafine 19.92 µM 0.964143081158914 0.236815964208793 no 832 0.167487098128899 806 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3196 9111891 49.47 µM 0.963237879514265 0.237094830921966 no 833 0.167714079857628 833 18891510
SGTC_1864 st057645 30.4 µM 0.96258863340139 0.237294956132509 no 834 0.167877001988054 823 688666
SGTC_36 0335-0881 14.2 µM 0.962533501218107 0.23731195448389 no 835 0.167890841576275 878 23828853
SGTC_290 2043-6722 48.1 µM 0.961656378384365 0.237582478869201 no 836 0.168111120630673 837 773758 YLR208W SEC13
SGTC_1506 4226-2149 212 µM 0.960582646403311 0.237913872190869 no 837 0.168381028802395 899 991114
SGTC_1833 st055984 71 µM 0.960546764573913 0.237924951022511 no 838 0.168390053366573 825 676288
SGTC_918 glabranin 770.725 nM 0.959016242490842 0.238397776485285 no 839 0.168775281371192 855 124049 Also referred to as licorice root.
SGTC_1944 st076371 56.9 µM 0.958751252565338 0.238479692267767 no 840 0.168842036040982 805 24208455
SGTC_851 0394-0702 453 µM 0.956521078229075 0.239169711623585 no 841 0.169404520202322 895 762646
SGTC_2620 irigenin 100 µM 0.955868862632586 0.239371714131442 no 842 0.169569245995387 867 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_6 0844-0013 19.835 µM 0.954721179394479 0.23972739772821 no 843 0.169859358207721 1042 1584900
SGTC_9 0092-0002 10.449 µM 0.954495217740692 0.239797460469832 no 844 0.169916514436345 849 759368
SGTC_768 0384-0033 77.3 µM 0.954478471713363 0.239802653267055 no 845 0.169920750777469 851 3965305 YMR134W ERG29
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.952476795379232 0.240423797386867 no 846 0.170427614374662 811 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1358 1509-0022 2.48 µM 0.950684168569657 0.240980813911469 no 847 0.170882363576309 877 3258434
SGTC_1459 k035-0031 35.7 µM 0.949742009873313 0.241273848648822 no 848 0.171121679068774 762 3877128 YMR208W ERG12
SGTC_2171 5739187 198.077 µM 0.947521333370989 0.241965299588721 no 849 0.171686595370281 793 2262761
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.946863881836409 0.24217021597151 no 850 0.171854072297975 810 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1379 2144-0755 36.5 µM 0.944255996664944 0.242983975054921 no 851 0.172519423171024 913 5392327
SGTC_1152 3909-8331 15.9 µM 0.94020036784734 0.244252418317565 no 852 0.173557396576909 831 16001939
SGTC_1093 fluphenazine 7.97 µM 0.939025445994909 0.244620554001099 no 853 0.173858839946135 887 6602611 An atypical antipsychotic.
SGTC_609 0986-0026 86.3 µM 0.938563055794259 0.244765515604292 no 854 0.173977564159384 865 2848610
SGTC_1350 1495-0454 146 µM 0.937544546822614 0.245084986231932 no 855 0.174239260293923 909 1069057
SGTC_345 1362-0200 395 µM 0.936958065015301 0.245269046758818 no 856 0.174390064614826 835 1419823
SGTC_1089 terbinafine 2.25 µM 0.936120304155793 0.245532097147154 no 857 0.174605625053975 872 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2174 5790901 200 µM 0.936092346358924 0.245540878290283 no 858 0.174612821663812 847 786020
SGTC_778 3456-2434 196 µM 0.93604634547927 0.245555326874154 no 859 0.17462466314919 971 5539063
SGTC_2301 7769476 200 µM 0.931435232878834 0.247005962691398 no 860 0.175814236358887 830 977820
SGTC_3008 9078912 71.4286 µM 0.93085514123442 0.247188781130796 no 861 0.175964250848059 844 16648731
SGTC_2007 4011539 71.82 µM 0.930425183992175 0.247324330730121 no 862 0.176075492143719 853 45595301
SGTC_1319 1306-0155 43.7 µM 0.93006295990814 0.247438557404255 no 863 0.176169243626996 894 3122360
SGTC_3266 9136860 49.47 µM 0.929150635825414 0.247726381948661 no 864 0.176405512947652 852 4871271 YPR165W RHO1
SGTC_3255 9139072 49.47 µM 0.928493988763811 0.247933654827484 no 865 0.176575692266455 891 17646060
SGTC_2272 7805186 180 µM 0.927071119532217 0.248383105715668 no 866 0.176944804930018 892 2956062 YPR165W RHO1
SGTC_1747 st037496 66.6 µM 0.926480361402144 0.248569839804928 no 867 0.177098199195652 895 723305
SGTC_1215 3852-0577 11.2 µM 0.925100584013809 0.249006267966196 no 868 0.177456794658295 954 2884876
SGTC_2495 cafestol 54.53 µM 0.924821442788363 0.249094610822292 no 869 0.177529397413118 819 16667697 An anti-infammatory.
SGTC_1960 st011366 51.8 µM 0.924734670837123 0.249122075880996 no 870 0.1775519700331 897 3972846
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.92398174331794 0.249360460119943 no 871 0.177747910599965 832 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2571 chrysanthemic acid 100 µM 0.923863530927664 0.24939789833279 no 872 0.177778686375476 817 2743 An insecticide.
SGTC_2855 9016525 58.44 µM 0.923239704979182 0.249595515324651 no 873 0.1779411508029 896 43811474
SGTC_2178 5812956 200 µM 0.921731614208972 0.250073595134278 no 874 0.178334292970393 892 5403383
SGTC_2442 5158906 48.48 µM 0.919060012681126 0.250921710621738 no 875 0.179032091617089 905 1893835
SGTC_145 3737-0113 38.366 µM 0.918692346106364 0.251038547575024 no 876 0.179128257171376 1010 6849351
SGTC_1343 1487-0095 224 µM 0.918635025273309 0.251056765562218 no 877 0.179143252730807 897 4560101 YGL055W OLE1
SGTC_2807 7945238 51.95 µM 0.91858609743535 0.251072316600034 no 878 0.179156053244508 875 17148797
SGTC_640 3381-0960 37.1 µM 0.918299571233834 0.251163395226984 no 879 0.179231025853401 943 1745025
SGTC_3304 9125678 46.087 µM 0.917849420272505 0.251306520852223 no 880 0.179348852455703 851 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_234 nsc-17383 10.7 µM 0.917656592911479 0.251367843555271 no 881 0.179399339737661 935 408974
SGTC_1573 oleylamine 1.06 µM 0.916468113349173 0.251745976807072 no 882 0.179710712213832 869 5356789 An amine of the fatty acid oleic acid.
SGTC_2970 9090938 41.86 µM 0.915967579781598 0.251905319185667 no 883 0.179841949700666 939 17217104
SGTC_847 0342-0274 5.54 µM 0.914987611035069 0.252217441443897 no 884 0.18009906703289 927 18097
SGTC_2319 6033012 152.6 µM 0.914173878258878 0.252476772069562 no 885 0.180312743817366 808 847246
SGTC_771 0250-0039 27.3 µM 0.913754338871783 0.252610531049681 no 886 0.180422972118714 861 3005115
SGTC_1826 st055655 41.6 µM 0.913525659955529 0.25268345495801 no 887 0.180483072209338 893 676168
SGTC_2379 9035213 200 µM 0.912768456175734 0.252925000401928 no 888 0.180682165815952 958 646551
SGTC_752 1896-0090 130 µM 0.9118824677661 0.253207781911208 no 889 0.180915295866771 913 772567
SGTC_1600 coumarin 106 71.1 µM 0.910168413851991 0.253755329241366 no 890 0.181366849575902 918 100336 A hepatotoxic, DNA x-linker.
SGTC_455 paf C-16 10 µM 0.909429622125121 0.253991524741681 no 891 0.181561695748057 861 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_316 k060-0003 58.6 µM 0.907741873639947 0.254531539047551 no 892 0.182007307507252 886 6152314
SGTC_1910 st062352 60.4 µM 0.907687127589792 0.254549065734868 no 893 0.182021773403297 917 2245730
SGTC_709 3807-1509 243 µM 0.907498256073798 0.254609536904296 no 894 0.182071685639827 905 1886677 YPL242C IQG1
SGTC_2069 5228469 200 µM 0.907485700427609 0.254613557123957 no 895 0.182075003967959 851 2835210
SGTC_2866 9034245 58.44 µM 0.906856993819129 0.254814906567807 no 896 0.182241213003105 903 6462273
SGTC_374 0880-0231 82.3 µM 0.906028302245743 0.255080430436776 no 897 0.182460436197634 914 6833587
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.903705103148054 0.255825585396055 no 898 0.18307589621718 875 5379071
SGTC_3083 9117465 49.47 µM 0.901936457847758 0.256393630695134 no 899 0.183545311540472 923 16420915
SGTC_948 3448-0295 75.3 µM 0.900749926533358 0.256775083379555 no 900 0.183860648300906 935 678569
SGTC_2295 7971645 200 µM 0.89956816685674 0.257155295474058 no 901 0.184175052104713 880 2978226 YKL099C UTP11
SGTC_555 4296-0685 37 µM 0.899214895148621 0.257269011750082 no 902 0.184269103968734 942 2908540 YHR072W ERG7
SGTC_3220 9131269 49.47 µM 0.899163554489263 0.257285540209237 no 903 0.184282774928448 901 17722206
SGTC_3025 9087895 49.47 µM 0.898199304198002 0.257596070577912 no 904 0.184539652142082 964 17173641
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.89775799771635 0.257738255278857 no 905 0.184657290862936 867 15053
SGTC_2867 9039098 71.43 µM 0.896133013280397 0.258262160597083 no 906 0.185090863500209 864 6463460
SGTC_2750 bromebric acid 70.15 µM 0.895581759967989 0.258440013472194 no 907 0.185238090508743 958 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.894368310739483 0.258831736476367 no 908 0.185562430876785 971 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_576 1073-0113 22.7 µM 0.89240199739011 0.259467149077849 no 909 0.186088750454135 1131 5439563
SGTC_2676 harmalol 100 µM 0.891851686094447 0.259645125920822 no 910 0.18623621686451 930 5459187 A monoamine oxidase inhibitor
SGTC_2567 aureobasidin a 60 nM 0.889123737313847 0.260528304710403 no 911 0.186968291495449 882 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_912 3474-0017 2.18 µM 0.888979954614636 0.260574897517171 no 912 0.187006926472245 950 3360550
SGTC_406 estrone 100 µM 0.888760284525894 0.260646089927205 no 913 0.187065962225388 956 5870 A steroid.
SGTC_690 glyoxal 20.3 µM 0.886320508115714 0.261437464384748 no 914 0.187722420487607 890 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_733 4069-0007 56.1 µM 0.885962043448298 0.261553841117378 no 915 0.187818990511731 958 5717425 YNL287W SEC21
SGTC_722 3534-0461 190 µM 0.883737788717497 0.262276546688079 no 916 0.188418888080007 952 658262
SGTC_1184 1269-1718 139 µM 0.883147638174997 0.262468470155288 no 917 0.188578254106628 953 5403821
SGTC_3295 9122362 53.5725 µM 0.880658258914664 0.263278834300413 no 918 0.189251407796845 884 4730473
SGTC_2487 5918373 44.05 µM 0.880509575187392 0.263327275513403 no 919 0.189291660166008 996 2876279
SGTC_2951 9072950 58.06 µM 0.880442886503146 0.263349004189619 no 920 0.1893097161573 1032 16488155
SGTC_2504 purpurogallin 52.29 µM 0.878644019151772 0.263935460915402 no 921 0.189797160244116 894 5281571 An antioxidant.
SGTC_2733 amorolfine 100 µM 0.878434001197402 0.264003973170961 no 922 0.189854119664673 904 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1917 st066507 28.5 µM 0.877173490993312 0.264415368350975 no 923 0.190196206149649 934 3156428
SGTC_1250 0485-0349 40.2 µM 0.876136123954811 0.264754180453714 no 924 0.190478018300972 898 6842794 YDL195W SEC31
SGTC_522 1273-0010 11.6 µM 0.873981120950736 0.265458726015505 no 925 0.191064267539948 925 5705015
SGTC_1645 Cervolide 78 µM 0.872811305726151 0.265841577333839 no 926 0.1913829681285 893 23173 A fragrance.
SGTC_1127 asiatic acid 681.4 nM 0.872174063689302 0.266050248417788 no 927 0.191556713225855 883 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_603 3794-0023 45.9 µM 0.871705817298377 0.266203633097132 no 928 0.191684442945788 943 3802260
SGTC_1383 3049-0032 20.7 µM 0.870859696254681 0.266480912642451 no 929 0.191915382744636 987 712864
SGTC_1857 st056007 79.3 µM 0.867485387112652 0.267588147459983 no 930 0.192838057487254 935 619834
SGTC_1107 amlodipine 47 µM 0.867318858107904 0.2676428517406 no 931 0.192883663416815 900 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_728 3030-5151 22.5 µM 0.865980496584284 0.268082704100404 no 932 0.193250428674222 918 3125388
SGTC_1496 4469-0713 57.4 µM 0.865853641275389 0.268124413954082 no 933 0.193285214236318 934 746691
SGTC_205 1486-1330 71.903 µM 0.865082192732252 0.268378135496095 no 934 0.193496838862769 926 4118834
SGTC_996 3970-0799 1.8 µM 0.864336561093516 0.268623480821054 no 935 0.193701515632975 1121 6615648 YGL040C HEM2
SGTC_447 ml7 120 µM 0.864167587619858 0.268679096124103 no 936 0.19374791739274 976 4216 Selective myosin light chain kinase inhibitor.
SGTC_578 3460-0051 92 µM 0.864012737829872 0.268730067890033 no 937 0.193790446601808 1053 2876744
SGTC_289 k017-0060 526 µM 0.86363947620516 0.268852954047737 no 938 0.193892985607984 966 5512909
SGTC_265 mycophenolic acid 32.932 µM 0.863431665060497 0.268921382397352 no 939 0.193950087904462 994 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2929 9013348 24.6 µM 0.862812015229558 0.269125473472559 no 940 0.194120415963571 922 2995952
SGTC_2184 6075246 200 µM 0.861742777827026 0.269477825696951 no 941 0.194414539910221 935 2267320
SGTC_2110 5483698 200 µM 0.861274321611182 0.269632271698031 no 942 0.194543487445077 954 2848765 YHR062C RPP1
SGTC_3121 9125696 49.47 µM 0.858789391380887 0.270452272700744 no 943 0.195228360749778 978 1235365
SGTC_1497 4476-2978 41.3 µM 0.858463437746061 0.270559926373478 no 944 0.195318305622066 1005 1528379
SGTC_3259 9138485 49.47 µM 0.858397716506479 0.270581634914904 no 945 0.195336444037584 1029 17646153
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.857918091428701 0.270740087372169 no 946 0.195468846822968 959 279621
SGTC_3314 9135860 59.4275 µM 0.855891530305025 0.27141010795929 no 947 0.196028890122697 1006 25252478
SGTC_901 1112-0062 60.1 µM 0.850753037094031 0.27311268842652 no 948 0.19745327719241 956 1908457
SGTC_1501 4491-0275 38.4 µM 0.850406855212537 0.273227581831962 no 949 0.197549463080072 993 5104718
SGTC_2648 atorvastatin 78.68 µM 0.850331863370823 0.273252473834534 no 950 0.197570303133354 965 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3048 9093155 49.47 µM 0.850179934509707 0.273302906944613 no 951 0.197612527873642 938 25236002
SGTC_2053 5265679 138 µM 0.849944197064149 0.273381169618841 no 952 0.197678055863354 985 764595
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.849107785837258 0.273658939997389 no 953 0.197910659213716 1012 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2352 9027995 87.8 µM 0.845036322496034 0.275013055101344 no 954 0.199045279695066 914 2997347
SGTC_1429 4049-0205 9.46 µM 0.844227167444415 0.275282562079241 no 955 0.199271238030035 1012 22774478
SGTC_1289 0976-0073 69.1 µM 0.844197659098085 0.275292392942629 no 956 0.199279481219311 995 3391136
SGTC_2451 5856223 45.7 µM 0.844127228985594 0.275315857809653 no 957 0.199299156779318 946 2179896
SGTC_2038 4100038 30.985 µM 0.843922232753573 0.275384161035014 no 958 0.19935643177722 941 3596803
SGTC_1453 4237-0541 195 µM 0.843338136188039 0.27557882339507 no 959 0.199519679993163 1000 739892
SGTC_96 0929-0093 37.281 µM 0.842633058733721 0.275813895262449 no 960 0.199716848112627 931 6991579
SGTC_1518 st038567 90.8 µM 0.841955344802393 0.27603993699835 no 961 0.199906474730346 976 77966
SGTC_765 1319-0117 244 µM 0.840239418215265 0.276612666038081 no 962 0.200387080595023 992 3487746 YGL099W LSG1
SGTC_369 0957-0393 4.5 µM 0.837630174654354 0.277484674303968 no 963 0.201119220206139 955 6997992
SGTC_432 NS 1619 61.3 µM 0.837242876037746 0.277614223790341 no 964 0.201228030670824 915 4552 A K+/calcium channel activator.
SGTC_2196 6573537 42.6665 µM 0.836264142158753 0.277941737099116 no 965 0.201503160478302 1007 2903087
SGTC_2235 salicylic acid 500 µM 0.835462425522167 0.27821015562337 no 966 0.201728697194859 1005 338 A COX inhibitor and kinase inhibitor.
SGTC_185 k048-0037 25.491 µM 0.83425207156432 0.278615627165148 no 967 0.202069476905451 1036 6827589
SGTC_1942 st076330 65.2 µM 0.834170833261158 0.278642852498493 no 968 0.202092362186222 1041 24208414
SGTC_1502 4534-4282 27.7 µM 0.834041998772914 0.278686031362729 no 969 0.202128658756484 955 3278949
SGTC_449 xestospongin c 11.1929 µM 0.83323102798554 0.278957902898663 no 970 0.202357223285504 989 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_830 4076-0286 57.8 µM 0.832813414912752 0.279097954682328 no 971 0.202474983890736 1080 6866659
SGTC_1588 farnesol 29.9 µM 0.832458375695534 0.279217048420082 no 972 0.202575131826707 973 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1036 k216-0215 33.5 µM 0.831864430176973 0.279416335677356 no 973 0.202742735609401 975 622330
SGTC_628 1636-0253 16 µM 0.830859773564168 0.279753586510314 no 974 0.203026425317828 999 4456143
SGTC_2945 9067681 61.76 µM 0.82990274440382 0.280075032961775 no 975 0.203296886558116 1011 16456930
SGTC_2853 9015042 58.44 µM 0.828942599444109 0.280397705734082 no 976 0.203568444286196 981 6457456
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.827479806639761 0.280889647447549 no 977 0.203982581481082 990 364106
SGTC_2954 9074818 52.69 µM 0.827407719828983 0.280913901246121 no 978 0.204003003240572 968 16648742
SGTC_3124 9127567 49.47 µM 0.827282112423387 0.280956164609108 no 979 0.204038589972706 973 17592030
SGTC_881 0833-0569 170 µM 0.826542504173007 0.281205084306511 no 980 0.204248208665452 950 5418700
SGTC_1952 st077036 64.1 µM 0.826104938706563 0.281352399773415 no 981 0.204372283185118 1047 2937007
SGTC_172 1112-0046 2.638 µM 0.823529916058664 0.282220088209672 no 982 0.205103356020344 901 2802135 YIL048W NEO1
SGTC_62 0180-0423 3.232 µM 0.82332958647077 0.282287645910645 no 983 0.205160296536019 1004 30102 YGL099W LSG1
SGTC_3012 9080433 71.4286 µM 0.822421485754751 0.282593984774811 no 984 0.20541852757262 1054 17688859
SGTC_2987 9018338 71.43 µM 0.821870713250837 0.282779860292987 no 985 0.205575241371322 1018 5055682
SGTC_401 neomycin 50 µM 0.819151339175395 0.283698458538203 no 986 0.206350036936377 977 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1808 st050063 61.5 µM 0.817202208566561 0.284357748399493 no 987 0.206906440301651 1006 4011993
SGTC_347 4534-1311 26.2 µM 0.815619271483171 0.284893712163399 no 988 0.207358961902047 1027 2862016
SGTC_2148 5546263 113.568 µM 0.814777390751592 0.285178959182674 no 989 0.207599872439965 1013 792097
SGTC_1406 3909-7906 11.9 µM 0.814644675444152 0.285223938355709 no 990 0.207637865014028 1032 X1406
SGTC_245 methotrexate 289.6 µM 0.813653108101264 0.285560102070657 no 991 0.207921852197879 1009 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1113 artemisinin 1.17947 µM 0.813558187154146 0.285592292302289 no 992 0.207949049799707 1056 2240 An anti-malaria and mitochondrial poison.
SGTC_787 4152-0075 138 µM 0.812322110408276 0.286011636571708 no 993 0.208303413338055 1004 9566539
SGTC_2762 leflunomide 42.06 µM 0.809439070372992 0.286990855704961 no 994 0.209131318216324 1025 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1732 st034308 51.822 µM 0.809007264563738 0.287137654360476 no 995 0.209255483842372 963 830119
SGTC_2020 4017018 200 µM 0.808363103333993 0.287356712374823 no 996 0.209440792832543 1039 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_893 0958-0369 48.9 µM 0.807140024047386 0.287772858783747 no 997 0.209792907581561 1052 6819948
SGTC_3311 9131146 2.8755 µM 0.807132703737202 0.287775350338345 no 998 0.209795016087506 1005 4900406 YPR165W RHO1
SGTC_515 4092-1064 102 µM 0.806136462560802 0.288114527895417 no 999 0.210082084669894 1076 717353
SGTC_626 0214-0009 33 µM 0.804547122989825 0.288656020293016 no 1000 0.210540532991272 1055 3437874
SGTC_365 0121-0052 13.6 µM 0.804018671888368 0.288836171173661 no 1001 0.21069309578156 1038 3101739
SGTC_1263 0774-1208 64.8 µM 0.801736149669953 0.289614898523087 no 1002 0.211352800057562 1072 906585
SGTC_2914 7968218 45.32 µM 0.800138301227214 0.290160621761693 no 1003 0.211815336102581 967 2977111
SGTC_1596 piperlongumine 63 µM 0.799950233292168 0.290224885468135 no 1004 0.211869815865257 1070 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1526 st051518 75 µM 0.79855579928779 0.290701578053999 no 1005 0.212274012963448 930 673993
SGTC_1713 st033146 12.748 µM 0.797664222416333 0.291006558800029 no 1006 0.212532685602597 1033 674619
SGTC_1308 1187-1617 41.4 µM 0.796804016392705 0.291300950164837 no 1007 0.212782431067272 1066 2882570
SGTC_2907 7721985 69.9 µM 0.795968771319118 0.291586931990153 no 1008 0.213025093423141 1053 3267881
SGTC_3074 9116018 49.47 µM 0.795730459353726 0.291668552267086 no 1009 0.213094359394729 1034 17027303
SGTC_286 k060-0067 22.9 µM 0.794741369677549 0.292007422730133 no 1010 0.213381981180447 1011 5985051
SGTC_329 k048-0121 21.3 µM 0.794419404681232 0.292117770184742 no 1011 0.213475655614392 1024 6832902
SGTC_1364 1653-0028 37.6 µM 0.791524124203918 0.293110943978255 no 1012 0.214319102133318 1009 5718652
SGTC_1365 1672-3266 55.4 µM 0.790188514468222 0.293569628066852 no 1013 0.214708841325515 1067 6415873
SGTC_68 0986-0284 82.829 µM 0.789956055703681 0.293649494565679 no 1014 0.214776716286986 889 423278 YIL048W NEO1
SGTC_2686 alizarin 95.37 µM 0.789458708386518 0.2938204033258 no 1015 0.214921977152364 1027 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1001 4048-4355 44.4 µM 0.788635261169035 0.294103474394312 no 1016 0.215162607838693 1027 21824233
SGTC_1792 st045773 43.6 µM 0.786540279720817 0.294824220106981 no 1017 0.215775515399376 1022 2919270
SGTC_1122 capsaicin 818.572 nM 0.784633383989176 0.295480964851569 no 1018 0.216334275376019 1062 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_384 k007-0144 5.16 µM 0.78239826768666 0.296251605811375 no 1019 0.216990275779739 1058 6824886
SGTC_923 1900-2434 73.3 µM 0.78228669094837 0.296290100262083 no 1020 0.217023053341187 1034 5910570
SGTC_405 ebelactone b 50 µM 0.781466387027564 0.2965731790098 no 1021 0.217264119376524 1046 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2332 7982454 138.89 µM 0.779659018683482 0.297197320716994 no 1022 0.217795803446636 1047 2981748
SGTC_2851 9015922 71.43 µM 0.777586472850274 0.297913774701941 no 1023 0.218406419095057 1053 2996893
SGTC_3302 9125395 16.351 µM 0.777015693326357 0.298111224472227 no 1024 0.218574755769215 1037 17599668
SGTC_142 0335-0849 62.6745 µM 0.773951437068859 0.299172260383054 no 1025 0.219479754999522 1106 3889043 YPR107C YTH1
SGTC_2804 7954240 19.48 µM 0.772800115647155 0.299571361874243 no 1026 0.219820342484297 1065 828705
SGTC_503 tyrphostin 8 294 µM 0.771739567616247 0.299939210436276 no 1027 0.220134345364198 1069 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.770715126729299 0.30029472929316 no 1028 0.220437901909894 1194 5282309
SGTC_2227 7312221 64.1025 µM 0.77064803346467 0.300318019780204 no 1029 0.220457790974803 1103 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3123 9126162 49.47 µM 0.768671957802421 0.301004352539965 no 1030 0.221044038040313 1166 25239884
SGTC_3036 9090181 49.47 µM 0.768289411565879 0.301137300567419 no 1031 0.221157631929076 1078 25236586
SGTC_764 1951-2361 146 µM 0.768116094466414 0.301197542952468 no 1032 0.221209107976092 1057 5438930
SGTC_167 3672-0051 66.205 µM 0.767838748140783 0.301293955605763 no 1033 0.221291495482483 1063 3237971
SGTC_2089 5281248 129.67 µM 0.765025129578293 0.302272825722882 no 1034 0.222128290426131 1068 2737878
SGTC_3112 9123419 49.47 µM 0.760041833422308 0.304010028056042 no 1035 0.223614789780788 1154 17015854
SGTC_3221 9128209 49.47 µM 0.759797490183917 0.304095321711542 no 1036 0.223687821690944 1067 16460723
SGTC_2968 9090663 33.37 µM 0.758314783010758 0.304613123456408 no 1037 0.224131279730682 1045 25236811
SGTC_2678 equilin 100 µM 0.758182724513724 0.304659260895946 no 1038 0.224170800876426 1121 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2165 5727197 32.143 µM 0.754603710947793 0.305910846612903 no 1039 0.225243398198311 1167 1361712
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.753266925276475 0.306378905361226 no 1040 0.2256447648935 1144 551469
SGTC_1356 1502-0781 85.8 µM 0.753211243391377 0.306398408538206 no 1041 0.225661492020604 1045 567702
SGTC_1765 st044815 90.4 µM 0.750104378991761 0.307487488859697 no 1042 0.226595921185675 1106 645695
SGTC_814 3342-0569 96 µM 0.749446796473399 0.30771821606486 no 1043 0.226793977221984 1124 4346283
SGTC_1612 st002233 45.4 µM 0.749425008764034 0.307725862061473 no 1044 0.2268005410922 1157 1035021
SGTC_953 1188-0045 9.7 µM 0.749088428494174 0.307843989335713 no 1045 0.22690195450044 1107 6144426
SGTC_441 propafenone 146 µM 0.747731833825642 0.308320305912474 no 1046 0.227310962816841 1111 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1377 2944-0135 198 µM 0.746885149521862 0.308617750584586 no 1047 0.227566445432053 1128 1894137
SGTC_3015 9080845 49.47 µM 0.745858077317343 0.308978735095255 no 1048 0.227876576084556 1161 5296973
SGTC_938 3126-1755 342 µM 0.74487637520362 0.309323945938256 no 1049 0.228173229116653 1144 1777771
SGTC_982 1491-0518 27.5 µM 0.744661754046881 0.309399438878134 no 1050 0.228238112749289 1060 3091256
SGTC_1270 0831-1170 17.3 µM 0.744291273164698 0.309529774367932 no 1051 0.228350139833789 1134 6764716
SGTC_282 k297-0036 65.7 µM 0.742579970452745 0.310132122858371 no 1052 0.228868009359488 1101 5061378
SGTC_3125 9127534 49.47 µM 0.741993211123269 0.310338769288752 no 1053 0.22904572442351 1022 1639235
SGTC_48 0382-0018 55 µM 0.740923580035528 0.310715628818751 no 1054 0.229369888650026 1206 762596
SGTC_328 k915-0120 63.5 µM 0.740166768429365 0.310982393762644 no 1055 0.229599404532535 1107 6624543
SGTC_1129 3453-1384 223 µM 0.739272399936552 0.311297773563307 no 1056 0.229870802645577 1144 1084452
SGTC_3209 9113616 49.47 µM 0.738910161628177 0.31142554854508 no 1057 0.229980775747654 1150 16649353
SGTC_3331 9141060 1.957 µM 0.735936592143242 0.312475295124465 no 1058 0.230884643481225 1127 4906567 YPR165W RHO1
SGTC_1743 st037606 46.3785 µM 0.735755345014635 0.312539329371498 no 1059 0.230939800735426 1132 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_14 0354-0009 295 µM 0.734388992242545 0.313022241119551 no 1060 0.231355846865277 1168 1713507
SGTC_2393 9031399 185.94 µM 0.732529686642676 0.313679893234884 no 1061 0.231922664977499 1157 1526623 YDL150W RPC53
SGTC_1658 st012944 20 µM 0.731410322812254 0.314076107590866 no 1062 0.232264280941214 1092 24207260
SGTC_909 3448-9333 149 µM 0.73069248959818 0.314330307480668 no 1063 0.232483502001242 1089 3344074
SGTC_2833 9001315 45.46 µM 0.729761540297599 0.314660107445593 no 1064 0.232767978465115 1113 2989378
SGTC_1667 st014849 34.6 µM 0.729595403024118 0.314718979130209 no 1065 0.232818766486413 1174 5348460
SGTC_789 1309-1135 70.6 µM 0.729127536184206 0.314884795701055 no 1066 0.232961826055589 1159 3092424
SGTC_935 2996-0153 430 µM 0.728578637689047 0.31507937825979 no 1067 0.233129724883592 1168 23738523
SGTC_2016 5121758 140 µM 0.728228890040677 0.315203389328798 no 1068 0.233236741844235 1173 2795203
SGTC_2245 6637752 200 µM 0.727457138057921 0.315477105404084 no 1069 0.233472981542719 1106 681890
SGTC_2811 7967822 32.47 µM 0.726820958560846 0.315702814362179 no 1070 0.233667821134286 1134 2232244
SGTC_1251 0490-5699 265 µM 0.726668280265404 0.315756993048067 no 1071 0.233714594580764 1195 3883818
SGTC_1167 k781-0610 148 µM 0.726586654567536 0.315785959974982 no 1072 0.233739602983197 1152 4525169
SGTC_3147 9097027 49.47 µM 0.726148173155292 0.315941585466545 no 1073 0.23387396987736 1157 25236841
SGTC_1637 st007924 17.4 µM 0.72608900061202 0.31596258944004 no 1074 0.23389210580646 1150 683336
SGTC_3163 9099914 49.47 µM 0.725626636443913 0.316126731363643 no 1075 0.234033843695411 1142 16268368
SGTC_2841 9004761 38.96 µM 0.725497237181232 0.316172675334882 no 1076 0.234073519600886 1094 2991039
SGTC_1565 sinapyl alcohol 95.1 µM 0.724894780368345 0.316386618541824 no 1077 0.234258291634961 1141 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.724748778463568 0.316438475689521 no 1078 0.234303082214021 1252 688664
SGTC_2838 9002687 71.43 µM 0.721770052183446 0.317497250377426 no 1079 0.235217932348961 1130 6457060
SGTC_176 1486-1328 72.834 µM 0.721580461688611 0.317564690140557 no 1080 0.235276227582567 1156 22310231
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.721364789141328 0.317641414984837 no 1081 0.235342552215382 1160 688798
SGTC_1794 st048918 76.9 µM 0.720960530750962 0.317785249760345 no 1082 0.235466899449354 1099 672303
SGTC_779 1360-0071 233 µM 0.719992414593665 0.318129816384438 no 1083 0.235764832962529 1233 7566
SGTC_1409 3909-8004 61.9 µM 0.719430601889858 0.318329845922322 no 1084 0.235937823632114 1170 2119279
SGTC_3198 9112019 49.47 µM 0.719242069546261 0.31839698343839 no 1085 0.235995891279223 1184 45595555
SGTC_2200 6600604 21.907 µM 0.713512239934495 0.320440247321869 no 1086 0.237764420904334 1139 2904777
SGTC_2843 9000894 45.46 µM 0.713163863082987 0.320564655426839 no 1087 0.237872182428592 1045 2242070
SGTC_1224 0823-0416 294 µM 0.712948882916054 0.32064143659044 no 1088 0.237938694439556 1175 3598164
SGTC_1221 2958-7315 257 µM 0.710879874192321 0.321380784623652 no 1089 0.238579339279663 1168 4562705
SGTC_2956 9076196 2.52 µM 0.709498573237949 0.321874778856459 no 1090 0.239007568286539 1188 16423868
SGTC_2976 9009005 19.48 µM 0.708469345352333 0.322243066155115 no 1091 0.239326921100685 1194 2993148
SGTC_877 0771-0151 33.1 µM 0.70829446799548 0.32230565965704 no 1092 0.239381205881801 1169 6166523
SGTC_1303 1160-0052 261 µM 0.70726186392277 0.322675360231977 no 1093 0.239701880062767 1198 3562476
SGTC_579 4491-1009 110 µM 0.706820491977404 0.322833437011307 no 1094 0.239839019168717 1318 1271041
SGTC_1707 st032323 6.317 µM 0.705543435666567 0.323290993292328 no 1095 0.240236055543635 1119 3132057 YMR211W DML1
SGTC_2661 dactinomycin 12.96 µM 0.705506496641422 0.323304232151845 no 1096 0.240247545201469 1187 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3227 9130768 49.47 µM 0.70535018473234 0.32336025644805 no 1097 0.240296168379072 1182 17720899
SGTC_2930 9013230 14.89 µM 0.704951426967018 0.323503194748879 no 1098 0.240420232279889 1157 2995857
SGTC_3166 9102297 49.47 µM 0.703678987484404 0.323959486202782 no 1099 0.240816354447071 1152 25237072
SGTC_3317 9138495 8.753 µM 0.703001407808112 0.324202571457932 no 1100 0.241027436068382 1188 17020139
SGTC_2658 polymyxin b sulfate 77.05 µM 0.702615667990128 0.324340991126498 no 1101 0.241147647802471 1169 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_469 w7 172 µM 0.701682681513517 0.324675886252691 no 1102 0.241438537870536 1230 45115570 A P450 inhibitor.
SGTC_691 1548-0686 185 µM 0.701578954344001 0.324713127842021 no 1103 0.241470890090642 1160 46495133
SGTC_2683 piperine 63.03 µM 0.701288076774927 0.324817572149904 no 1104 0.241561626566024 1146 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2679 rapamycin 1 nM 0.700619211968712 0.325057791142648 no 1105 0.241770342760473 1201 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_411 enrofloxacin 100 µM 0.70032790540016 0.325162434985267 no 1106 0.24186127422399 1241 71188 A bacterial gyrase inhibitor.
SGTC_2144 5628481 200 µM 0.699841017658649 0.325337366749138 no 1107 0.242013297846708 1179 2818399
SGTC_1769 st044406 64.4 µM 0.699515447067496 0.325454361057959 no 1108 0.242114981439255 1197 670903
SGTC_1804 st050076 49.1 µM 0.699384192986658 0.325501532286108 no 1109 0.242155981823322 1194 3895976
SGTC_1557 sumaresinolic acid 42.3 µM 0.698567064707523 0.325795261763915 no 1110 0.242411316229459 1146 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1896 st058441 89 µM 0.695055751031632 0.32705868734727 no 1111 0.24351018182131 1151 688759
SGTC_1460 k062-0059 9.15 µM 0.693497602061419 0.327619970359884 no 1112 0.243998665080354 1181 1373085
SGTC_2300 7976697 71.57 µM 0.693121368185058 0.327755557386445 no 1113 0.244116694440023 1121 2236109
SGTC_3172 9105863 49.47 µM 0.691502986502758 0.32833904796925 no 1114 0.244624752281315 1179 2348785
SGTC_2443 5493264 126.67 µM 0.690475234703903 0.328709810753985 no 1115 0.24494768934158 1201 5340055
SGTC_999 SEC7.066 22.7 µM 0.689268789694257 0.329145252541064 no 1116 0.245327067331903 1216 740511 YDR170C SEC7
SGTC_2359 9039622 200 µM 0.689111916192143 0.32920188989092 no 1117 0.245376420874899 1177 6463596
SGTC_853 0419-0306 21 µM 0.687209688541671 0.329888978662705 no 1118 0.245975299931246 1158 762713
SGTC_1238 0333-0287 48.8 µM 0.686345429977272 0.330201340637753 no 1119 0.246247653669808 1213 7226
SGTC_888 0916-0002 6.97 µM 0.685574847425558 0.330479945890784 no 1120 0.246490623574635 1249 2802138 YIL048W NEO1
SGTC_2142 5622915 118.518 µM 0.684003717289409 0.331048281307616 no 1121 0.246986409237936 1197 5322196
SGTC_2467 5474540 200 µM 0.682280125417198 0.331672215781082 no 1122 0.247530918879043 1213 5413519
SGTC_2536 dehydroabietamide 32.04 µM 0.681945581358804 0.331793373811427 no 1123 0.247636680856869 1229 3983547
SGTC_1603 st002045 67.8 µM 0.680117419839608 0.332455768856292 no 1124 0.248215057649272 1222 5887985
SGTC_1140 3229-1848 2.98 µM 0.679472063794717 0.332689724897265 no 1125 0.248419401309213 1228 2849525
SGTC_1781 st038725 66.3 µM 0.6783441493003 0.333098775648689 no 1126 0.248776756048544 1239 4270275 YIL048W NEO1
SGTC_2329 6138490 200 µM 0.678290777294934 0.333118136526763 no 1127 0.248793672566538 1204 720019
SGTC_105 0111-0055 734.78 µM 0.677743148120622 0.333316816575899 no 1128 0.248967281685228 1183 5179370
SGTC_2306 7482397 179.52 µM 0.67714255212594 0.333534766787179 no 1129 0.249157756415778 1237 891448
SGTC_174 3553-0389 74.3 µM 0.675928692322099 0.333975435743688 no 1130 0.249542959887072 1213 738071
SGTC_1791 st048313 56.1 µM 0.675586259926297 0.334099790823619 no 1131 0.249651683786355 1174 1204976
SGTC_584 0986-0246 15.4 µM 0.671942535719923 0.335424143094362 no 1132 0.250810139949745 1319 53315 YDR232W HEM1
SGTC_2523 spermine 47.74 µM 0.671002012222755 0.335766320009316 no 1133 0.251109623823234 1202 1103 A DNA binding polyamine.
SGTC_1052 3253-3998 198 µM 0.670530794924069 0.335937807344936 no 1134 0.251259741128154 1224 5450317
SGTC_3310 9130229 44.1445 µM 0.669939413112127 0.336153073779033 no 1135 0.251448206778527 1245 7761258
SGTC_663 1486-0733 13.9 µM 0.667334184056277 0.337102031418645 no 1136 0.252279347903444 1243 722445 YPR165W RHO1
SGTC_148 3253-0744 288.01 µM 0.666408221150243 0.337439564693409 no 1137 0.252575104563582 1219 6893655
SGTC_1392 3455-1037 33.9 µM 0.665998229744232 0.337589057136325 no 1138 0.252706115957073 1256 981132
SGTC_35 0133-0054 64.071 µM 0.665656616044424 0.33771363704842 no 1139 0.252815304807031 1190 99677
SGTC_2738 aclarubicin 5.55 µM 0.665512074728564 0.33776635382692 no 1140 0.252861511543362 1155 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_463 ikarugamyin 104 µM 0.664099962482677 0.338281543483974 no 1141 0.253313167082791 1289 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_668 1682-0499 62.6 µM 0.663609698001305 0.338460480602159 no 1142 0.253470074329703 1263 682214
SGTC_834 0312-0008 75.7 µM 0.662963121152377 0.338696524508713 no 1143 0.253677086810842 1262 6385573 YIL048W NEO1
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.662883908745186 0.338725446708005 no 1144 0.253702454102554 1238 688667
SGTC_2791 5663188 71.43 µM 0.661903827466874 0.339083374655384 no 1145 0.254016429343202 1236 54690634
SGTC_478 N-arachidonylglycine 10 µM 0.661655872221446 0.339173951525044 no 1146 0.25409589567626 1192 5283389
SGTC_2666 tannic acid 100 µM 0.661454430591958 0.339247544036061 no 1147 0.254160464617934 1266 16134267 A thiamine antagonist.
SGTC_3349 9149703 23.001 µM 0.661037755872634 0.339399786940561 no 1148 0.254294050439923 1235 4910494
SGTC_1185 1319-0113 81.3 µM 0.660604843387647 0.339557990502536 no 1149 0.25443288106448 1269 4672763
SGTC_2415 st077333 57.7 µM 0.659459562890456 0.339976658154501 no 1150 0.254800352299326 1303 2766255
SGTC_80 0159-0065 512.242 µM 0.656043171954615 0.341226721943291 no 1151 0.255898173481605 1201 1548079
SGTC_2407 paclitaxel 400 µM 0.656008750591226 0.341239325682889 no 1152 0.255909246970196 1356 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3101 9120531 49.47 µM 0.655949271298629 0.341261105060871 no 1153 0.255928382282957 1315 24824904
SGTC_2076 5212012 200 µM 0.65562091556472 0.341381347741793 no 1154 0.256034032309482 1166 604802
SGTC_2619 obliquin 87.91 µM 0.655263827385007 0.341512130419503 no 1155 0.256148952956686 1242 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2825 7998094 58.44 µM 0.653726843726963 0.342075264027456 no 1156 0.256643902809261 1250 2987815
SGTC_2135 5326629 150.42 µM 0.653552056340845 0.342139326448346 no 1157 0.256700220544551 1238 5020077
SGTC_1016 4226-1401 38 µM 0.653096966316927 0.342306145660096 no 1158 0.25684688395807 1255 2901613
SGTC_666 0272-0154 136 µM 0.652672067582569 0.342461925640152 no 1159 0.256983856877059 1284 6870312
SGTC_1987 st072290 61.9 µM 0.651643321901195 0.342839204077668 no 1160 0.257315646852981 1277 54697379
SGTC_2709 st078560 56 µM 0.650843519354382 0.343132629097467 no 1161 0.257573752074135 1282 17250903
SGTC_2133 5320837 200 µM 0.650040482866732 0.343427335748059 no 1162 0.257833036130897 1264 2841355
SGTC_2524 avocatin b 10.57 µM 0.649757871118905 0.343531074196295 no 1163 0.257924317895273 1207 6710748
SGTC_427 1354-0053 47.3 µM 0.649735328917484 0.343539349282118 no 1164 0.257931599602296 1322 6813657
SGTC_687 k029-0044 34.9 µM 0.649016624902321 0.343803219831091 no 1165 0.258163815256947 1289 5829338
SGTC_1847 st056231 15 µM 0.648451806867238 0.344010644908018 no 1166 0.258346385872942 1287 5393180
SGTC_3021 9087658 49.47 µM 0.647768985983917 0.344261468308288 no 1167 0.258567188781654 1256 25237042
SGTC_2064 5220758 200 µM 0.645402837703538 0.345131164784815 no 1168 0.259333082471692 1308 788518
SGTC_124 0136-0217 7.121 µM 0.645175017126037 0.345214945311592 no 1169 0.259406887063108 1393 3976905
SGTC_1431 4049-0260 9.09 µM 0.644107134799076 0.345607757801429 no 1170 0.259752982031777 1267 3854841
SGTC_2586 curcumin 80 µM 0.643810653906884 0.345716845582367 no 1171 0.259849112153438 1291 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_769 0302-0231 76 µM 0.643139573505863 0.345963811571739 no 1172 0.260066769124726 1285 571869 YER009W NTF2
SGTC_2728 chlorpromazine 9.18 µM 0.642689436681425 0.346129504291639 no 1173 0.260212818320495 1288 2726 A thorazine and dopamine antagonist.
SGTC_729 4092-0585 94.1 µM 0.642224061702697 0.34630083706076 no 1174 0.26036385604106 1256 2169061
SGTC_2775 cyproheptadine 69.59 µM 0.641525138635616 0.346558212145171 no 1175 0.2605907767436 1284 2913 A selective serotonin reuptake inhibitor.
SGTC_2687 chenodiol 100 µM 0.641248817275657 0.346659985716187 no 1176 0.260680518607761 1297 5702181 A cholesterol synthesis inhibitor.
SGTC_660 4031-1742 102 µM 0.640903634319171 0.346787137661296 no 1177 0.260792647236742 1209 6738706
SGTC_1384 3089-0840 101 µM 0.640234700989358 0.347033595742816 no 1178 0.261010012988183 1268 1069836
SGTC_605 1315-0399 119 µM 0.638558618581185 0.347651406284391 no 1179 0.261555054414144 1328 24020461
SGTC_1846 st056244 14.8 µM 0.638533568242832 0.347660643011653 no 1180 0.261563204905745 1307 5393182
SGTC_452 diindolylmethane 8 µM 0.63746051154654 0.34805639245123 no 1181 0.261912461859043 1284 3071 Inhibits expression of several cancer promoting factors.
SGTC_1396 3511-0007 98.6 µM 0.637347064666493 0.348098241992049 no 1182 0.26194940035958 1243 X1396
SGTC_3352 9151559 45.5865 µM 0.636295339235251 0.348486302125203 no 1183 0.2622919711008 1248 17159339
SGTC_3327 9140648 26.9345 µM 0.63618881758676 0.348525614777598 no 1184 0.262326680402518 1272 8029710
SGTC_3333 9141820 12.094 µM 0.635696005093458 0.348707512274016 no 1185 0.262487290367664 1291 1939433
SGTC_1209 2323-2347 50.3 µM 0.635389673303946 0.34882059712317 no 1186 0.262587150737462 1259 5412760
SGTC_2942 9052777 62.25 µM 0.634696720470997 0.349076455789551 no 1187 0.262813116491876 1373 6469503
SGTC_215 1287-0124 461.5 µM 0.634398194106907 0.349186701702739 no 1188 0.262910493923697 1315 5560863
SGTC_1194 1488-0194 225 µM 0.63421814493445 0.349253200092556 no 1189 0.262969233753771 1289 1391452
SGTC_824 1304-0008 100 µM 0.633014049131221 0.349698033221258 no 1190 0.26336223427766 1293 768245
SGTC_2388 9080168 200 µM 0.632749267822331 0.349795879972444 no 1191 0.263448695507545 1240 15943073
SGTC_3159 9100096 49.47 µM 0.631711631819739 0.350179421994473 no 1192 0.263787662962393 1250 25236875
SGTC_2606 farnesol 9.78 µM 0.630463434554137 0.350640996421599 no 1193 0.264195709525146 1325 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_482 fipronil 114 µM 0.629178998208955 0.351116202092384 no 1194 0.264615938315642 1320 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2765 myclobutanil 7.74 µM 0.62914294891776 0.351129542689539 no 1195 0.26462773745866 1312 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_954 1189-0853 2.85 µM 0.62871015476878 0.351289719169795 no 1196 0.264769414394614 1276 2828194
SGTC_2512 diallyl trisulfide 49.23 µM 0.628551343246954 0.351348501708203 no 1197 0.264821411666768 1291 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2798 7813637 45.45 µM 0.627916339054186 0.351583577848932 no 1198 0.265029373418876 1300 956368
SGTC_998 3996-0085 177 µM 0.626893793251621 0.351962239700444 no 1199 0.265364428038925 1322 715391
SGTC_2718 lomofungin 53.02 µM 0.626684415003386 0.352039793283355 no 1200 0.265433060910098 1345 5351222 A RNA synthesis inhibitor.
SGTC_627 1391-0720 175 µM 0.624913032069316 0.352696158526858 no 1201 0.266014069304676 1277 997839
SGTC_1328 1441-0025 69.2 µM 0.624594399775074 0.352814270613672 no 1202 0.26611864807984 1234 4562601
SGTC_3046 9092212 49.47 µM 0.62446901574381 0.352860752434445 no 1203 0.266159806264977 1322 25236637
SGTC_341 1486-1430 230 µM 0.624431843203457 0.352874533298454 no 1204 0.266172009030685 1261 2054753 YPL210C SRP72
SGTC_2555 cholic acid 100 µM 0.624386114727869 0.352891486343356 no 1205 0.266187020873075 1305 6708657 Influences liver metabolism.
SGTC_2757 clomiphene 4.22 µM 0.623462938818341 0.353233800340701 no 1206 0.266490174694583 1361 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_139 0099-0334 718.624 µM 0.622513757403685 0.353585881042063 no 1207 0.266802050218765 1331 97690
SGTC_2622 2-methoxyxanthone 59.94 µM 0.621202040200176 0.354072643639669 no 1208 0.267233348621313 1344 71034 A hepatoprotective.
SGTC_89 0302-0250 142.109 µM 0.621084734771438 0.354116185916972 no 1209 0.267271936297199 1348 4203518 YLR208W SEC13
SGTC_1762 st045503 25.4615 µM 0.620949454537817 0.35416640258072 no 1210 0.267316440284255 1314 4645554
SGTC_896 0964-0007 44.5 µM 0.619518382333224 0.354697778532057 no 1211 0.267787457946712 1299 6756758
SGTC_2675 theaflavin digallate 100 µM 0.618910765273435 0.354923480353012 no 1212 0.267987573098694 1322 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2070 5230947 200 µM 0.618770673902251 0.354975525087702 no 1213 0.268033722057943 1362 2835538
SGTC_671 0560-0003 407 µM 0.618347759263453 0.355132656674237 no 1214 0.268173063044409 1262 3238678
SGTC_3117 9124945 49.47 µM 0.616286540785067 0.355898843188325 no 1215 0.268852710153778 1227 17592065
SGTC_1985 st071382 65.5 µM 0.615657502500765 0.356132782495585 no 1216 0.269060295551654 1333 6123237
SGTC_2344 7990960 76.95 µM 0.614382196768269 0.356607234785046 no 1217 0.269481398752368 1326 140813
SGTC_77 0828-0286 12.516 µM 0.613688884744268 0.356865261004853 no 1218 0.269710467411603 1283 745345
SGTC_506 n9-isopropylolomoucine 153 µM 0.612697880300486 0.357234191514381 no 1219 0.270038062184969 1347 6610355
SGTC_1814 st052110 31.539 µM 0.611947553515423 0.357513611525329 no 1220 0.270286228891071 1314 674163
SGTC_2803 7707263 71.43 µM 0.611514853352331 0.357674782837278 no 1221 0.270429394054593 1318 2199229
SGTC_2797 7859098 81.82 µM 0.611131153864088 0.357817723707564 no 1222 0.270556378324412 1339 972681
SGTC_2152 5568786 200 µM 0.610524903830055 0.358043612722966 no 1223 0.270757075767383 1299 5399883
SGTC_547 1120-0019 610 nM 0.609039658897449 0.358597225522887 no 1224 0.271249075990088 1334 3676939
SGTC_1581 himbacine 57.9 µM 0.608930879390612 0.358637783884073 no 1225 0.271285127649656 1313 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1324 1418-0026 34.4 µM 0.606371230844367 0.359592606242063 no 1226 0.272134133972459 1350 1372513
SGTC_2305 7443522 69.23 µM 0.60571607982908 0.359837137602651 no 1227 0.272351652224871 1319 5415886
SGTC_178 4092-0806 87.505 µM 0.605613140245666 0.359875564430954 no 1228 0.272385837291619 1332 2169044
SGTC_2073 5212005 126 µM 0.605421443849383 0.359947127505079 no 1229 0.272449503167685 1233 691789
SGTC_704 1310-0270 142 µM 0.604786285749034 0.36018427640193 no 1230 0.272660503573627 1295 5718033
SGTC_983 1491-0821 12.2 µM 0.602474090961819 0.361048034177492 no 1231 0.273429302222208 1332 46495113
SGTC_2932 9016711 44.54 µM 0.601919264152571 0.361255404358325 no 1232 0.273613940203311 1359 7117328
SGTC_1210 3013-0140 750 nM 0.601368186148102 0.361461413762657 no 1233 0.273797391687419 1392 905973
SGTC_1839 st053978 48 µM 0.60130379442624 0.361485487932292 no 1234 0.273818831381391 1373 3788398
SGTC_664 1222-0054 14.9 µM 0.60082296187423 0.361665274402771 no 1235 0.273978954330672 1323 6813991
SGTC_3066 9117245 49.47 µM 0.600093936998815 0.3619379198717 no 1236 0.274221816513104 1419 17176980
SGTC_2645 abamectin 100 µM 0.599994937798294 0.36197494964486 no 1237 0.274254804602789 1310 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1853 st056710 91.2 µM 0.599961121193628 0.361987598742072 no 1238 0.274266073275993 1490 269167
SGTC_1793 st048256 72.231 µM 0.597613721127799 0.362866011200005 no 1239 0.2750488533429 1285 672022
SGTC_2145 5634607 200 µM 0.596906495989884 0.363130801228148 no 1240 0.275284905005676 1308 308662
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.595920627994057 0.363500026247741 no 1241 0.275614126032551 1350 229346 A bile salt which induces apoptosis.
SGTC_352 k048-0007 5.11 µM 0.594934254620602 0.363869567479241 no 1242 0.275943709447987 1315 6811911
SGTC_3269 9137823 49.47 µM 0.593995876053544 0.364221245196862 no 1243 0.276257435620481 1291 17682936
SGTC_381 3461-2219 42.7 µM 0.592851949810643 0.364650111015483 no 1244 0.276640118692386 1365 2883159
SGTC_1485 3909-9022 254 µM 0.592566063828867 0.364757318122971 no 1245 0.276735798047239 1345 714516
SGTC_1467 k284-1082 293 µM 0.59160203884274 0.365118904952306 no 1246 0.277058554135488 1394 3334705
SGTC_525 k781-2675 26.7 µM 0.591254607762445 0.36524924894736 no 1247 0.277174919396748 1390 3651118 YDL195W SEC31
SGTC_344 k064-0035 6.43 µM 0.589825318155752 0.365785632046949 no 1248 0.277653883430614 1312 5088750
SGTC_1982 st072467 71.9 µM 0.589782150085166 0.365801836228006 no 1249 0.277668355613127 1346 3163533
SGTC_1264 0783-0040 158 µM 0.588239645331527 0.366381009686135 no 1250 0.278185725113834 1318 2855798
SGTC_1053 3366-3204 134 µM 0.587672318367006 0.366594103980818 no 1251 0.278376129685754 1302 3632071 YPR165W RHO1
SGTC_1193 1488-0126 41.5 µM 0.585130317759819 0.367549411735842 no 1252 0.279230047307804 1354 1384710
SGTC_16 erodoxin 22.806 µM 0.584397529823359 0.367824952899567 no 1253 0.279476444141116 1381 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_92 0063-0024 660.874 µM 0.583894588195468 0.368014107186584 no 1254 0.279645617209832 1371 3594437
SGTC_815 1582-0027 36.9 µM 0.583614825556757 0.368119338626343 no 1255 0.279739741694442 1396 3128206
SGTC_2553 4-methylesculetin 85.09 µM 0.583196486980536 0.368276713233982 no 1256 0.279880517906038 1348 5319502
SGTC_2003 4023581 200 µM 0.583160131256843 0.368290390922234 no 1257 0.279892753688515 1388 16641307
SGTC_638 3970-0837 4.09 µM 0.582673512940555 0.368473481697614 no 1258 0.280056553581902 1353 4118451 YLR208W SEC13
SGTC_1111 tnp00062 510.699 nM 0.580701135899272 0.3692158966039 no 1259 0.28072094801718 1460 676306
SGTC_372 0155-0182 15.9 µM 0.580545156107029 0.369274629222781 no 1260 0.280773522259456 1367 771486
SGTC_1090 efavirenz 20.7 µM 0.580106019709135 0.369439997992848 no 1261 0.280921562278128 1387 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2485 5633444 17.78 µM 0.580050028313203 0.369461084814973 no 1262 0.280940440599466 1324 5724239
SGTC_1432 4049-0298 68.4 µM 0.579931571286155 0.369505698003804 no 1263 0.280980382146307 1412 741646
SGTC_1019 4262-0212 3.4 µM 0.579732646615593 0.36958062080343 no 1264 0.281047462086245 1405 4677213
SGTC_1181 1222-0449 220 µM 0.579247833008201 0.369763241279544 no 1265 0.281210979827505 1416 658318
SGTC_587 k089-0003 57 µM 0.578597432160216 0.370008281596701 no 1266 0.281430418897786 1338 9659696
SGTC_2990 9074105 71.4286 µM 0.577166733063999 0.370547487059163 no 1267 0.281913413772169 1368 6502001
SGTC_1132 3456-3614 2.5 µM 0.575873399042492 0.371035141007396 no 1268 0.28235037846746 1529 3125502
SGTC_672 1441-0018 53.7 µM 0.572471273254903 0.372318906177973 no 1269 0.28350137103878 1333 251141
SGTC_3019 9081971 49.47 µM 0.565628945807753 0.374905091748233 no 1270 0.285823023216931 1470 16451803
SGTC_1802 st050112 57.9 µM 0.56459477773524 0.37529646799085 no 1271 0.286174709070658 1361 4662563
SGTC_273 hydroxyurea 18.1 mM 0.562678864851874 0.37602187560383 no 1272 0.286826789308679 1417 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_562 3772-2733 112 µM 0.561080751900804 0.376627292433514 no 1273 0.287371244551896 1389 2876874 YIL048W NEO1
SGTC_222 nsc-310342 10.666 µM 0.556591126081575 0.378329727758694 no 1274 0.288903409061302 1405 432556
SGTC_639 0833-0042 114 µM 0.556480110449541 0.37837185421769 no 1275 0.288941343771896 1369 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2872 9044037 25.97 µM 0.555948414524651 0.37857363382577 no 1276 0.289123059959641 1430 6465195
SGTC_2128 5255449 168.493 µM 0.555789045518659 0.378634121116495 no 1277 0.289177537512861 1367 736008
SGTC_342 k048-0088 23.3 µM 0.554755911277527 0.379026311390427 no 1278 0.289530813677363 1375 6820570
SGTC_864 0469-0573 172 µM 0.554022462785716 0.379304812957735 no 1279 0.289781736431309 1358 689425
SGTC_307 1501-1223 22.3 µM 0.554003883542689 0.379311868593567 no 1280 0.289788093969083 1394 2830329
SGTC_2056 5235370 200 µM 0.553954678107654 0.379330554997435 no 1281 0.289804931645689 1381 5511916
SGTC_561 1550-0330 72.9 µM 0.552827585292477 0.379758660257095 no 1282 0.290190738715114 1357 6812934
SGTC_1326 1431-2094 10.8 µM 0.552750107005787 0.379788094365483 no 1283 0.290217268589617 1378 616278
SGTC_1240 0356-0016 42.1 µM 0.552265505417638 0.379972210975269 no 1284 0.290383230135074 1441 4305613
SGTC_187 1488-2104 32.728 µM 0.549206276069558 0.381135142597065 no 1285 0.291431948927733 1476 2852859
SGTC_2640 pentamidine 10.38 µM 0.548478923621644 0.381411795917262 no 1286 0.291681548646417 1447 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_94 0334-0113 514.748 µM 0.54825864054652 0.38149559400659 no 1287 0.291757161079556 1355 6795178
SGTC_3233 9132340 49.47 µM 0.547885685308968 0.381637482917839 no 1288 0.291885199236514 1377 17682950
SGTC_2580 diallyl disulphide 81.36 µM 0.54753458429225 0.381771072038268 no 1289 0.29200575859658 1438 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1936 st074407 74.3 µM 0.547280119171345 0.381867901328226 no 1290 0.292093150080301 1415 809813
SGTC_2600 tangeritin 87.95 µM 0.547240955440108 0.38188280460188 no 1291 0.292106601242537 1354 68077 A bioactive flavone.
SGTC_1548 st061468 90.8 µM 0.543550407492851 0.383287979590254 no 1292 0.293375447191359 1412 390799
SGTC_1349 flufenamic acid 69 µM 0.543432465660366 0.38333291134547 no 1293 0.293416038807791 1386 3371 A non-steroidal anti-inflammatory.
SGTC_1478 0453-0656 35.7 µM 0.543028876317205 0.383486676783143 no 1294 0.293554960382716 1429 5258496
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.539935760636276 0.384665745406313 no 1295 0.294620667488899 1472 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1455 4262-0120 131 µM 0.539526166849353 0.38482195925395 no 1296 0.294761923314193 1500 1529587
SGTC_713 1488-1073 324 µM 0.53847262126969 0.385223853955436 no 1297 0.295125400945421 1417 3312542
SGTC_2286 7945697 125 µM 0.536661021907296 0.385915210569586 no 1298 0.295750892410874 1368 1245733
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.536163797621417 0.386105028657161 no 1299 0.295922675664105 1448 368090
SGTC_2998 9066762 71.4286 µM 0.536120975024323 0.386121377693486 no 1300 0.295937472347642 1526 4945196
SGTC_69 0096-0274 206.684 µM 0.534812300205867 0.386621107840557 no 1301 0.296389828343424 1515 6741392
SGTC_20 0481-0013 4.944 µM 0.534483147465847 0.386746827633293 no 1302 0.296503653011791 1409 182045
SGTC_2433 5607874 27.82 µM 0.534162789740463 0.386869199586523 no 1303 0.296614455497648 1398 2252428
SGTC_1385 3091-4834 14.1 µM 0.531921683525895 0.387725583219956 no 1304 0.297390119292856 1475 4072814
SGTC_1861 st057647 17.4 µM 0.531372844778253 0.387935391911083 no 1305 0.297580217673169 1540 688668
SGTC_3267 9137951 49.47 µM 0.531066385997512 0.388052558439349 no 1306 0.297686388310582 1471 16643986
SGTC_2995 9067767 71.4286 µM 0.530377558055482 0.388315951033501 no 1307 0.297925091301987 1449 11673567
SGTC_1389 3405-0187 19 µM 0.529845343684004 0.388519493243117 no 1308 0.298109581944706 1379 799890
SGTC_465 cgp-37157 41 µM 0.527978021614218 0.389233881222581 no 1309 0.298757295279164 1418 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3080 9117754 49.47 µM 0.525599701370851 0.390144305659929 no 1310 0.299583182131593 1558 9550191
SGTC_516 3992-2719 87.3 µM 0.525295038565471 0.390260974688489 no 1311 0.299689052944385 1353 5350887 YDR037W KRS1
SGTC_2376 9072922 81.32 µM 0.525012484610406 0.390369186082873 no 1312 0.299787256041279 1473 17087968
SGTC_840 0245-0196 390 µM 0.524029156967102 0.390745843172027 no 1313 0.300129130218343 1520 3827528
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.521589781045338 0.391680671807127 no 1314 0.300977989929014 1486 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1307 1187-1599 12.2 µM 0.521069302758695 0.391880213034502 no 1315 0.301159247195482 1413 1538471
SGTC_1336 1486-0901 104 µM 0.520514547615264 0.392092926654641 no 1316 0.30135249555068 1484 5006114
SGTC_2587 piperic acid 92.2 µM 0.51949526385706 0.392483841738375 no 1317 0.301707707391428 1414 5370536
SGTC_1470 k295-0292 231 µM 0.51803628315465 0.393043577849935 no 1318 0.302216477244859 1508 5045612
SGTC_2005 4024620 188 µM 0.51771724701094 0.393166005179548 no 1319 0.302327781522538 1432 236743
SGTC_3210 9128157 49.47 µM 0.517386405369104 0.393292973925937 no 1320 0.30244322388216 1432 17590849
SGTC_917 harmaline 728.087 nM 0.517066245124912 0.393415854225662 no 1321 0.302554957939697 1500 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2883 9059145 45.46 µM 0.515761702991296 0.393916658545672 no 1322 0.303010426695528 1429 16476510
SGTC_866 0495-0101 262 µM 0.515700208933284 0.393940270008587 no 1323 0.303031904344456 1399 635694
SGTC_1927 st060202 13.8 µM 0.515082282985846 0.394177552537472 no 1324 0.303247761314156 1463 688887
SGTC_3279 9140807 49.47 µM 0.514314904843004 0.394472279132695 no 1325 0.303515921315629 1454 45595718
SGTC_2961 9083290 32.55 µM 0.51367752083215 0.39471712487981 no 1326 0.303738735399173 1490 17741490
SGTC_1062 mesoridazine 14.2 µM 0.513230486338522 0.394888874269928 no 1327 0.303895051416825 1472 4078 A neuroleptic.
SGTC_3232 9132874 49.47 µM 0.513115714938495 0.394932972414582 no 1328 0.303935189696123 1426 3784940
SGTC_2146 5545642 200 µM 0.512338775435156 0.395231528064264 no 1329 0.3042069660018 1459 825326
SGTC_314 1671-0008 2.74 µM 0.51123275146932 0.395656647541781 no 1330 0.304594043894582 1406 3913060
SGTC_303 1348-1668 34.2 µM 0.510811761220467 0.395818495093932 no 1331 0.304741436418627 1470 5380509
SGTC_190 3970-0790 3.722 µM 0.510494497629521 0.395940477333825 no 1332 0.304852534241454 1521 2832352
SGTC_890 0929-0006 47.2 µM 0.510004875690707 0.396128748306225 no 1333 0.305024022984786 1421 1378169
SGTC_2197 6588183 93.1375 µM 0.509681044234401 0.396253282314392 no 1334 0.305137467597659 1447 884136
SGTC_356 1634-0012 32.5 µM 0.509235504530011 0.396424638267352 no 1335 0.305293579638527 1495 735457
SGTC_1643 st009866 20.2 µM 0.50797468441038 0.396909661924184 no 1336 0.305735548541102 1481 3156273 YOR207C RET1
SGTC_2290 7904846 200 µM 0.507801518205735 0.396976289537171 no 1337 0.305796272489539 1464 2962154
SGTC_149 3970-0822 46.1 µM 0.505254731493228 0.397956540274032 no 1338 0.306689966660544 1513 3114250 YBL034C STU1
SGTC_2722 naftopidil 47.16 µM 0.504239609510947 0.398347437740835 no 1339 0.307046504596202 1507 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_197 4544-0043 41.561 µM 0.504169783108357 0.398374329854265 no 1340 0.307071036205897 1469 896523
SGTC_2880 9042983 58.44 µM 0.503467049912698 0.398644999041848 no 1341 0.30731797049131 1473 6464714
SGTC_2274 7947094 46.08 µM 0.499904711045861 0.400017839630896 no 1342 0.308571087461912 1451 2971028
SGTC_2214 7179297 48.276 µM 0.499641021596056 0.400119508628601 no 1343 0.308663933915305 1524 769744
SGTC_402 epigallocatechin gallate 10 µM 0.499105292771899 0.400326086891383 no 1344 0.308852604544238 1461 65064 An antioxidant.
SGTC_1154 4088-0362 150 µM 0.498845021869172 0.400426458017373 no 1345 0.308944283822723 1455 6618304
SGTC_661 1304-0007 33.6 µM 0.496892840831958 0.401179508232701 no 1346 0.309632310159988 1472 3117130
SGTC_505 gw-5074 63.9 µM 0.49664618891973 0.401274679940434 no 1347 0.309719287669152 1555 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2598 perillyl alcohol 100 µM 0.495744093969554 0.401622807029908 no 1348 0.310037486490837 1540 10819 An apoptosis inducer.
SGTC_1519 esterone 74 µM 0.494539860123628 0.402087654073474 no 1349 0.310462481516133 1413 698 A steroid.
SGTC_15 0266-0086 27.098 µM 0.49265644723097 0.402814948958845 no 1350 0.311127678068741 1553 1712902 YIL048W NEO1
SGTC_191 3914-0123 66.505 µM 0.492606852207113 0.402834105029176 no 1351 0.311145202728161 1415 3144412
SGTC_207 4185-0010 4.486 µM 0.492322865229881 0.402943799445802 no 1352 0.311245559246383 1537 3761753
SGTC_1211 1056-0033 32.3 µM 0.491487520312947 0.403266508754712 no 1353 0.311540838283898 1511 6741922
SGTC_1371 2421-0008 32.7 µM 0.491374058090597 0.403310346412947 no 1354 0.311580954445873 1507 2827552
SGTC_464 bw-b 70c 158 µM 0.490335486727135 0.403711668848144 no 1355 0.311948259821288 1550 5353454
SGTC_274 sirtinol 40.1 µM 0.490289249242412 0.403729538194759 no 1356 0.311964616710783 1447 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2017 5132927 60.65 µM 0.490218741621495 0.403756787579335 no 1357 0.31198956007388 1453 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1131 3454-3128 32.3 µM 0.48771610148138 0.404724295323049 no 1358 0.312875472592447 1593 710982
SGTC_1452 4194-0072 190 µM 0.487595366566342 0.404770985600126 no 1359 0.312918239078785 1618 1343545
SGTC_1632 st005650 90 µM 0.487090226621113 0.404966346638274 no 1360 0.313097196063506 1509 2759605
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.48659866245778 0.405156480033588 no 1361 0.313271385806062 1536 688801
SGTC_1073 triclabendazole 3.09 µM 0.486575262427896 0.405165531551262 no 1362 0.313279678835459 1530 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2326 6164455 177.58 µM 0.486525207667426 0.405184893728853 no 1363 0.313297418685375 1510 2888790
SGTC_1347 1493-0251 600 nM 0.485246465037199 0.405679615397535 no 1364 0.313750762788081 1602 3986378
SGTC_2727 riluzole 51.77 µM 0.484227429798407 0.406073969057282 no 1365 0.314112236056999 1504 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2311 7694451 200 µM 0.483437101988485 0.406379881504851 no 1366 0.31439270483903 1572 2163142
SGTC_617 3770-0098 35 µM 0.482420051834766 0.406773635520849 no 1367 0.314753789749141 1517 5962639
SGTC_1662 st014054 52 µM 0.482000040081192 0.406936271855594 no 1368 0.314902958898481 1476 2838777
SGTC_611 3453-1652 23.7 µM 0.481581556764942 0.407098332313493 no 1369 0.315051615253192 1567 1560575
SGTC_757 1066-0008 322 µM 0.479284841711163 0.407988033042596 no 1370 0.315868002175274 1568 6842497
SGTC_1868 st057644 42.7 µM 0.478624950843585 0.408243749333515 no 1371 0.31610273243541 1487 688665
SGTC_1902 st060212 70.5 µM 0.478129642935193 0.408435713270058 no 1372 0.316278967490831 1488 688944
SGTC_1874 staurosporine 7.6 µM 0.475581908405124 0.409423471865939 no 1373 0.317186133410837 1579 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3325 9138760 55.175 µM 0.475421144962756 0.409485819334523 no 1374 0.317243413014163 1473 43844959
SGTC_2642 cholecalciferol 100 µM 0.475113744269203 0.409605042208048 no 1375 0.317352951283415 1548 9821465 A vitamin D precursor, similar to steriods.
SGTC_1558 st069300 45.6 µM 0.474655188112884 0.409782905038537 no 1376 0.317516381582546 1581 24208000
SGTC_2890 9046729 58.44 µM 0.473706671106822 0.410150870702518 no 1377 0.317854547744931 1443 903329
SGTC_2132 5317594 122.667 µM 0.473136131817827 0.410372242629783 no 1378 0.318058030158059 1556 794577
SGTC_2603 homopterocarpin 100 µM 0.472857477467141 0.410480372213719 no 1379 0.318157431995918 1526 101795 A weak amylase inhibitor.
SGTC_2343 7990716 14.84 µM 0.472597664451992 0.410581196699212 no 1380 0.318250124535134 1553 6456862
SGTC_348 k064-0012 10.7 µM 0.471224019820605 0.41111435894675 no 1381 0.318740383761958 1486 5066323
SGTC_3243 9134147 49.47 µM 0.470920185498949 0.411232310490297 no 1382 0.318848866336755 1568 24282180
SGTC_1604 st002052 72.4 µM 0.469966513575114 0.41160258761216 no 1383 0.319189471075709 1544 6254834 YHR062C RPP1
SGTC_836 0330-0104 1.35 µM 0.469631971664903 0.411732497091279 no 1384 0.319308989192259 1548 46494820
SGTC_942 3253-1115 227 µM 0.467748420057823 0.41246409898173 no 1385 0.319982255213258 1610 46497897
SGTC_1611 st001856 99.4 µM 0.466755324369231 0.41284995605854 no 1386 0.320337471300648 1478 647478
SGTC_2216 7189485 200 µM 0.465813380886431 0.413216016306138 no 1387 0.320674543168339 1591 731273
SGTC_254 nsc-64875 3.808 µM 0.465608304420317 0.413295723608808 no 1388 0.320747948831393 1645 56993
SGTC_2424 5537928 59.2 µM 0.464937612003789 0.413556427330024 no 1389 0.320988067349171 1509 5382802
SGTC_1872 amphotericin b 148 nM 0.464884818134117 0.41357695036587 no 1390 0.321006971571997 1603 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3120 9124077 49.47 µM 0.464602240531267 0.413686803311735 no 1391 0.321108163744128 1548 18774327 YGL155W CDC43
SGTC_2508 celastrol 40.54 µM 0.462960298889487 0.414325246778131 no 1392 0.32169641231256 1479 122724 Celastrol is a natural product and antioxidant.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.461922370953896 0.41472894583442 no 1393 0.322068495359005 1560 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3292 9120825 59.784 µM 0.461357915917593 0.414948526821496 no 1394 0.322270919736736 1645 24824900
SGTC_1770 st043884 66.3 µM 0.460986625959494 0.415092978356104 no 1395 0.322404100169494 1529 670149
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.460820909844068 0.415157454442069 no 1396 0.322463549329916 1566 7104
SGTC_2824 7998404 51.95 µM 0.460069577407134 0.41544980815105 no 1397 0.322733139994069 1567 837851
SGTC_613 3914-0030 117 µM 0.459429808917074 0.415698787714274 no 1398 0.322962773122078 1475 1145395
SGTC_2256 7954252 200 µM 0.458923979267407 0.415895666083119 no 1399 0.323144379157482 1508 2972920
SGTC_1353 1498-1206 8.11 µM 0.457110580557838 0.416601647965438 no 1400 0.323795782841116 1528 6756808
SGTC_2459 5811157 9.22 µM 0.456755874293129 0.416739771690125 no 1401 0.323923262587374 1506 2870684 YBR192W RIM2
SGTC_79 0052-0007 94.094 µM 0.456402309137971 0.416877461293223 no 1402 0.324050352779926 1631 2801472
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.456398230428294 0.416879049733019 no 1403 0.324051819005624 1447 641818 YHR062C RPP1
SGTC_1583 clindamycin 39.6 µM 0.454111271245044 0.417769911267117 no 1404 0.324874370589418 1473 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_831 k061-1017 217 µM 0.453947295438591 0.417833802637162 no 1405 0.324933380716 1624 1240153
SGTC_1426 4048-4480 71.7 µM 0.452592207829422 0.418361880491543 no 1406 0.325421205386516 1621 14224343
SGTC_2091 4-phenylthiadiazole 200 µM 0.450354462374142 0.419234252033846 no 1407 0.326227437239024 1572 270010
SGTC_3247 9135149 49.47 µM 0.44734493407597 0.420408124039751 no 1408 0.327313014078009 1549 8934436 YOR116C RPO31
SGTC_1891 st059073 26.2 µM 0.446943382052565 0.420564803920291 no 1409 0.327457969985511 1698 688754
SGTC_2981 9013952 38.96 µM 0.446834899739491 0.420607134334188 no 1410 0.327497135383821 1454 2996344
SGTC_1136 pergolide 1.05886 µM 0.44543667313364 0.421152812294403 no 1411 0.328002107309048 1568 47811 A dopamine receptor agonist.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.444188861507475 0.421639916614948 no 1412 0.32845302229149 1533 260807
SGTC_2558 carylophyllene oxide 100 µM 0.442205543854725 0.422414384632963 no 1413 0.329170237364891 1617 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1425 4048-4433 7.33 µM 0.441024425886575 0.42287574350885 no 1414 0.329597656974134 1619 23734946
SGTC_118 0083-0097 135.343 µM 0.440341603312626 0.423142510517518 no 1415 0.329844856483963 1588 5207356
SGTC_2093 5331342 194.4 µM 0.439998013576927 0.42327675844009 no 1416 0.329969273013994 1639 33839
SGTC_3136 9095672 49.47 µM 0.439978289069347 0.423284465501271 no 1417 0.329976415983466 1631 17217380
SGTC_1878 temozolomide 1 mM 0.439903301911637 0.423313765897957 no 1418 0.330003572156362 1686 5394 DNA alkylating agent.
SGTC_2087 5276107 200 µM 0.439473686586966 0.423481641471572 no 1419 0.330159172168401 1547 144405
SGTC_258 haloperidol 50.781 µM 0.438742154436552 0.423767525372321 no 1420 0.330424189370302 1525 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1678 st019265 80.2 µM 0.438281413196912 0.423947604370238 no 1421 0.330591148950852 1715 5367020
SGTC_2294 7971431 200 µM 0.435633005104207 0.424983031709638 no 1422 0.331551510135556 1573 5741572
SGTC_340 k038-0059 454 µM 0.435520375353192 0.425027077207587 no 1423 0.331592376356958 1611 23733424
SGTC_2173 5763948 167 µM 0.435009303196082 0.425226951139075 no 1424 0.331777837336252 1584 2867177
SGTC_32 0928-0142 34.1 µM 0.43363402835732 0.425764899246382 no 1425 0.332277110126905 1597 2244242
SGTC_1031 k035-0009 16 µM 0.43360761074851 0.425775234029749 no 1426 0.332286703559382 1704 5180959
SGTC_2011 4012611 177 µM 0.432839983702965 0.426075558209379 no 1427 0.332565511738418 1530 2049887
SGTC_2030 5175110 200 µM 0.432539376595105 0.426193178556217 no 1428 0.332674719857018 1633 2831986
SGTC_2336 9001819 198.65 µM 0.432445576412078 0.426229881661159 no 1429 0.332708799608257 1673 2989602
SGTC_2370 9071495 200 µM 0.432110467600096 0.426361011717041 no 1430 0.332830563591786 1541 21791103
SGTC_419 nsc-638432 893 µM 0.431877364306024 0.426452231213786 no 1431 0.332915273601301 1575 368090
SGTC_973 1325-0077 65.9 µM 0.431094564877847 0.426758590140286 no 1432 0.333199806215026 1698 2835149
SGTC_83 0170-0301 39.027 µM 0.430105406677899 0.427145773482549 no 1433 0.333559483622022 1590 3089716
SGTC_11 0438-0307 1.3 µM 0.429821270995762 0.427257004887133 no 1434 0.333662829262773 1668 4011476
SGTC_721 1187-1332 279 µM 0.429488970897565 0.427387098689131 no 1435 0.333783709245181 1531 25730
SGTC_475 α-linolenic acid 10 µM 0.42948186662651 0.427389880061457 no 1436 0.33378629373665 1657 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1934 st074720 32.6 µM 0.429393606641472 0.427424434770244 no 1437 0.33381840285068 1522 17250992
SGTC_1151 3909-8316 15.3 µM 0.428618939362616 0.427727748986313 no 1438 0.334100280152076 1574 800431
SGTC_1474 0330-0125 5.35 µM 0.428068818299821 0.427943170038841 no 1439 0.334300508926593 1564 X1474
SGTC_1359 1582-0056 520 nM 0.427853388453988 0.428027535733681 no 1440 0.334378932254065 1630 3661189
SGTC_1873 rapamycin 2 nM 0.42773041269748 0.428075696437444 no 1441 0.334423702588646 1576 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_837 0091-0265 12.5 µM 0.42718700599156 0.428288522334306 no 1442 0.334621562452189 1552 759367
SGTC_2067 5224629 34.075 µM 0.427141113681387 0.428306497069442 no 1443 0.334638274409476 1554 2835000
SGTC_1748 st037455 53.6035 µM 0.426390724356993 0.42860042466666 no 1444 0.334911579588803 1639 580690
SGTC_376 3970-0862 59.1 µM 0.426379939534584 0.428604649372121 no 1445 0.334915508251371 1686 3135186
SGTC_511 blebbistatin 171 µM 0.424943510647433 0.429167410184765 no 1446 0.335438927527056 1675 3476986 A myosin inhibitor.
SGTC_2098 5376439 882.5 nM 0.424412134474124 0.42937562807226 no 1447 0.335632636331887 1700 2844116
SGTC_1949 st076024 69.1 µM 0.4243960682713 0.429381923863754 no 1448 0.335638493814413 1535 2921930
SGTC_949 1165-0505 146 µM 0.421236874299981 0.430620250205343 no 1449 0.33679106027858 1572 6244267
SGTC_550 4123-0385 25.7 µM 0.419002806899684 0.431496362416928 no 1450 0.337607040490614 1558 5731123
SGTC_481 bay k-8644 50 µM 0.418871635848491 0.431547812995768 no 1451 0.337654973743306 1550 2303 A calcium channel antagonist.
SGTC_2784 7567673 72.73 µM 0.417778451668784 0.43197664902881 no 1452 0.338054553540131 1576 3471247
SGTC_317 4495-0002 170 µM 0.417334893393421 0.432150671667269 no 1453 0.338216734681077 1579 15991618
SGTC_1733 st037357 54.9 µM 0.416419280362528 0.432509938659105 no 1454 0.338551611247406 1505 1272339 YGL099W LSG1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.41625116250004 0.432575910589315 no 1455 0.338613112605253 1547 5355888
SGTC_2378 9074213 121.43 µM 0.415537758358453 0.432855881792085 no 1456 0.338874140016692 1575 657714
SGTC_975 1335-0046 28.5 µM 0.415229563892357 0.432976841307928 no 1457 0.338986929222097 1523 16486740
SGTC_1930 st074634 34.3 µM 0.413873108454078 0.43350929458076 no 1458 0.339483519491869 1524 684253 YOR116C RPO31
SGTC_2166 5933061 31.504 µM 0.411665698971694 0.434376032852188 no 1459 0.340292234788568 1741 2877375
SGTC_1787 fluconazole 80 µM 0.411330809504143 0.434507554709982 no 1460 0.340414990535782 1555 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3351 9150312 21.596 µM 0.406147172477354 0.436544251234502 no 1461 0.342317233488759 1597 4904905
SGTC_2270 7924575 90.91 µM 0.405708337130961 0.436716751541128 no 1462 0.34247845786993 1769 1262135
SGTC_2062 5245942 200 µM 0.405324567880373 0.436867615966884 no 1463 0.342619474965341 1621 1376160
SGTC_2984 9022109 38.96 µM 0.403655512469183 0.437523848760145 no 1464 0.343233029037078 1646 6459207
SGTC_1278 0874-0585 172 µM 0.402608794853256 0.437935480989506 no 1465 0.343618019333008 1655 766306
SGTC_2250 alverine citrate 130 µM 0.402483908654065 0.437984598237105 no 1466 0.343663964221398 1590 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1777 st045864 34.765 µM 0.402461547524523 0.437993392881679 no 1467 0.343672190991484 1631 4691462
SGTC_1436 4092-1007 8.32 µM 0.402054205232137 0.438153606186133 no 1468 0.343822067189488 1616 2881121
SGTC_1380 2291-0730 164 µM 0.401990651783905 0.438178603542911 no 1469 0.343845453052768 1590 2999191
SGTC_553 k007-0256 45.7 µM 0.401560287326424 0.438347884461359 no 1470 0.344003830663276 1643 6287000
SGTC_580 1123-0028 41 µM 0.401246200155084 0.438471435626342 no 1471 0.344119434569256 1654 1677248 YPR107C YTH1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.400992304747983 0.438571313790774 no 1472 0.344212894756089 1730 756377
SGTC_2818 7996756 12.99 µM 0.399902602846015 0.439000028462745 no 1473 0.344614127551889 1595 2241621
SGTC_2269 7935389 174.42 µM 0.399734777859203 0.439066061180702 no 1474 0.344675936964746 1555 97605
SGTC_1824 st053723 68.6 µM 0.398228916126029 0.439658635876231 no 1475 0.34523072644323 1563 675225
SGTC_2419 paclitaxel 166.5 µM 0.396685404455305 0.440266166600735 no 1476 0.345799732279533 1660 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1635 st007035 42.4 µM 0.395867181954208 0.440588278514842 no 1477 0.346101506251165 1622 3716403
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.395557411843913 0.440710236842177 no 1478 0.346215780105099 1690 5377381
SGTC_2018 5133068 143 µM 0.395010289647033 0.440925655823488 no 1479 0.34641764708539 1614 785362
SGTC_18 0111-0177 500 nM 0.394506518766771 0.441124021506621 no 1480 0.34660355768689 1656 721752
SGTC_1047 2043-3044 82 µM 0.394390913986742 0.44116954432809 no 1481 0.346646225458692 1576 669592
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.393668386572629 0.441454078580211 no 1482 0.346912942180575 1706 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_194 1486-1323 56.904 µM 0.393500653919107 0.441520136712608 no 1483 0.346974870553531 1597 5178754
SGTC_2484 5809818 12.04 µM 0.393168052900839 0.441651129744076 no 1484 0.347097681866228 1662 2870548
SGTC_3241 9133421 49.47 µM 0.393065992456711 0.441691326953559 no 1485 0.347135370411031 1652 17018221
SGTC_3275 9138069 49.47 µM 0.392892934722673 0.441759488307356 no 1486 0.347199280056604 1685 17617007
SGTC_1149 3909-7961 23.3 µM 0.392821644982905 0.441787567329776 no 1487 0.34722560838425 1586 735261
SGTC_753 1322-0200 289 µM 0.392303581236231 0.441991626839783 no 1488 0.347416958927804 1650 5403907
SGTC_2643 anethole 100 µM 0.391902219402589 0.442149729359165 no 1489 0.347565231527238 1644 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2592 piperlongumine 83.33 µM 0.389838292515617 0.44296288648933 no 1490 0.348328063082785 1573 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1477 0139-0234 16 µM 0.38867556965053 0.443421088401728 no 1491 0.348758078374762 1679 620880
SGTC_1188 1403-0014 4.57 µM 0.388082114820046 0.443654984286006 no 1492 0.348977633534009 1636 9614867
SGTC_1870 st057514 26.5 µM 0.387410673027734 0.443919640512373 no 1493 0.349226101802939 1618 5393161
SGTC_3116 9124943 49.47 µM 0.387299741294219 0.443963367895656 no 1494 0.349267158519307 1551 41905195 YPL160W CDC60
SGTC_128 0906-2981 13.371 µM 0.386748508565955 0.44418066447286 no 1495 0.349471200286436 1722 6740226
SGTC_23 0213-0011 39.996 µM 0.386666027683935 0.444213179976538 no 1496 0.34950173477277 1746 627608
SGTC_2120 5538279 151.968 µM 0.385096489870238 0.444831992395622 no 1497 0.350082964265712 1659 2058197
SGTC_3303 9125618 40.5795 µM 0.384149468474511 0.445205434081908 no 1498 0.350433834237118 1739 22695467
SGTC_412 gemfibrozil 100 µM 0.383778035919438 0.445351915451139 no 1499 0.350571484298909 1677 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_986 1493-0483 84 µM 0.383270808920887 0.445551961944395 no 1500 0.350759490434542 1732 40079
SGTC_2857 9024691 58.44 µM 0.382551870876367 0.445835529412682 no 1501 0.351026030903708 1644 16478292
SGTC_2150 5556613 200 µM 0.382380129427973 0.445903272717861 no 1502 0.351089713510975 1678 743190
SGTC_2957 9076800 11.52 µM 0.381878655808668 0.446101087699122 no 1503 0.351275686422089 1601 16459615
SGTC_3180 9109287 49.47 µM 0.380969692487202 0.446459678236881 no 1504 0.351612868805157 1656 18891271
SGTC_235 0330-0087 5 mM 0.380935801520545 0.44647304923985 no 1505 0.35162544300996 1648 46494818 YHR062C RPP1
SGTC_2104 5389443 200 µM 0.379704619048486 0.446958828800136 no 1506 0.352082345513313 1731 2244536
SGTC_931 2812-0076 566 µM 0.378438077839455 0.447458642674633 no 1507 0.352552592881996 1638 3450959
SGTC_3059 1327-0034 3 µM 0.378192766645019 0.447555459253894 no 1508 0.352643699256208 1620 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_556 4058-0063 51.5 µM 0.377912502889944 0.44766607432877 no 1509 0.352747797042361 1664 6615692
SGTC_2617 dihydrotanshinone i 20.83 µM 0.377097806887712 0.4479876433032 no 1510 0.353050460477299 1622 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1352 1496-0991 99 µM 0.375616471727257 0.448572429118651 no 1511 0.353601021685027 1646 3000039
SGTC_2516 gossypol 71.55 µM 0.375011218387662 0.448811396857844 no 1512 0.353826061721454 1801 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_654 1124-0271 80.9 µM 0.374370487169997 0.449064392302512 no 1513 0.354064348496689 1613 5403748
SGTC_231 b-estradiol 524 µM 0.374104142544684 0.449169565709862 no 1514 0.354163418403908 1633 450 A steroid.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.371665311182643 0.450132769649204 no 1515 0.355071027701706 1694 2724278 An inhibitor of dopamine biosynthesis.
SGTC_963 1269-2853 151 µM 0.370221378237444 0.450703182406741 no 1516 0.355608774487459 1608 3668223
SGTC_2896 9052656 71.43 µM 0.368860597248389 0.451240839957706 no 1517 0.3561158171768 1671 6469436
SGTC_2570 licareol 100 µM 0.36822887338692 0.45149047054931 no 1518 0.356351291343541 1638 443158
SGTC_880 0833-0487 87.2 µM 0.367975934575747 0.451590426669363 no 1519 0.356445589287008 1642 76075
SGTC_2778 tioconazole 65.09 nM 0.367759622750737 0.451675911006652 no 1520 0.356526239312025 1619 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3154 9100113 49.47 µM 0.367606657084145 0.451736362908706 no 1521 0.356583275133372 1629 25237525
SGTC_759 3486-0358 89.3 µM 0.367433324390062 0.451804865195301 no 1522 0.356647909019662 1844 875103
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.366322505624077 0.452243902478848 no 1523 0.357062218971419 1661 16486 A toxic proline analog.
SGTC_2789 5281112 71.43 µM 0.365112937281103 0.452722035706932 no 1524 0.357513552014496 1616 765948
SGTC_175 3793-3120 23.7 µM 0.364991954978252 0.452769862880377 no 1525 0.357558705799112 1669 5322297
SGTC_1661 st013063 9.66 µM 0.364942679109111 0.452789342996459 no 1526 0.357577097423909 1684 721395
SGTC_198 3454-2873 16.191 µM 0.364542295116141 0.452947630088492 no 1527 0.357726548186161 1701 710957
SGTC_3282 9108498 15.4605 µM 0.364301988382979 0.453042636114843 no 1528 0.357816257614944 1644 16459645
SGTC_1032 k061-1018 98.7 µM 0.362327169064431 0.453823488492156 no 1529 0.358553778770323 1836 4005393
SGTC_2191 5911152 200 µM 0.360934608006053 0.454374220868579 no 1530 0.359074165770383 1691 2875902
SGTC_1575 cyproterone acetate 48 µM 0.360582592697275 0.454513450404133 no 1531 0.359205752048514 1613 9880 An androgen receptor antagonist and liver toxin.
SGTC_1447 4239-0816 81.9 µM 0.360084193444206 0.454710587454775 no 1532 0.359392086437436 1624 1341554
SGTC_333 3486-0131 40.1 µM 0.359178929003037 0.455068684632298 no 1533 0.359730619278946 1819 6744690
SGTC_244 nsc-207895 1.295 µM 0.358321965409124 0.455407709000375 no 1534 0.360051190969652 1637 42640
SGTC_632 0781-2353 4.65 µM 0.358319156162863 0.455408820423109 no 1535 0.360052242010406 1730 6811515 YHR007C ERG11
SGTC_1068 loratadine 26.9 µM 0.358166588975644 0.455469181137832 no 1536 0.360109324508648 1666 3957 A H1 histamine antagonist.
SGTC_3032 9089427 49.47 µM 0.356818654621234 0.456002513844827 no 1537 0.360613784990404 1664 17173707
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.356502696453072 0.456127539469269 no 1538 0.360732066548757 1806 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2465 5809242 33.21 µM 0.35613099246228 0.456274629448618 no 1539 0.360871234074525 1748 2731748
SGTC_2522 biochanin a 4.94 µM 0.353756816771645 0.45721427415239 no 1540 0.361760569305732 1753 5280373 A possible chelator.
SGTC_2810 7959871 45.46 µM 0.35239584502094 0.457753024015913 no 1541 0.362270708795503 1765 2974535
SGTC_390 dec-rvkr-cmk 16.7 µM 0.351239326926603 0.458210900575449 no 1542 0.362704404323014 1741 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_34 0469-0683 81.75 µM 0.350607953193752 0.458460890908201 no 1543 0.362941244540388 1773 3690923
SGTC_3301 9125354 19.7965 µM 0.348990929752896 0.45910122066524 no 1544 0.363548059501262 1661 41905162
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.348027090615888 0.459482944680483 no 1545 0.363909919205033 1676 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1578 josamycin 24.2 µM 0.347681366314912 0.459619876305696 no 1546 0.364039746078421 1649 5282165 A P450 substrate.
SGTC_1249 0481-0015 10.2 µM 0.346396765844237 0.460128712086591 no 1547 0.364522277663937 1669 4227577
SGTC_731 3966-0296 387 µM 0.345337573400459 0.460548311935816 no 1548 0.364920301314639 1710 660956
SGTC_1266 0828-0227 32.9 µM 0.343047606436619 0.461455633553975 no 1549 0.36578132298667 1782 3913820
SGTC_2240 6690706 185.951 µM 0.341525301579509 0.462058906467383 no 1550 0.366354080358363 1610 805876
SGTC_3187 9109394 49.47 µM 0.341315760939443 0.46214195201791 no 1551 0.366432942018675 1660 17098090
SGTC_2864 9034755 47.6 µM 0.340679074839086 0.462394294791962 no 1552 0.366672596587115 1812 4930451
SGTC_2682 pyrogallin 40.03 µM 0.339864802160546 0.462717043885613 no 1553 0.366979172144617 1763 822798 An ATP competetive kinase inhibitor.
SGTC_2634 4'-methoxyflavone 100 µM 0.339519578682081 0.462853885770454 no 1554 0.367109175211459 1699 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2920 7982904 15.77 µM 0.33912545169955 0.463010117711556 no 1555 0.367257612819855 1673 6456808
SGTC_2292 7671323 168.05 µM 0.337124257053552 0.463803478830172 no 1556 0.368011616097229 1701 937504
SGTC_1657 st012939 43.4 µM 0.335846466441388 0.464310126444679 no 1557 0.368493324033187 1814 24207257
SGTC_3038 9091290 49.47 µM 0.335688959904671 0.464372582258137 no 1558 0.368552715968479 1800 25236843
SGTC_2711 st079103 59.1 µM 0.335484533024423 0.464453644628752 no 1559 0.36862980512206 1819 54693780
SGTC_1685 st024049 53.0905 µM 0.333773444395124 0.465132208341415 no 1560 0.369275261836534 1740 1941139
SGTC_745 0469-0705 296 µM 0.3324529751478 0.465655934169955 no 1561 0.369773621304445 1850 3486736
SGTC_621 3584-0052 32.1 µM 0.332397016334074 0.465678129930714 no 1562 0.369794745608503 1830 2273927
SGTC_868 0527-0199 213 µM 0.332188516587201 0.465760831166915 no 1563 0.369873457170039 1726 2849450
SGTC_2777 climbazole 1.536 µM 0.331499957011148 0.466033958186163 no 1564 0.370133436725507 1755 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1879 gemcitabine 100 µM 0.330299454017101 0.466510193082766 no 1565 0.37058685272054 1773 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3355 9151058 44.0485 µM 0.329955708110667 0.46664656461591 no 1566 0.370716714687388 1754 17015728
SGTC_754 3474-0146 171 µM 0.329512369726948 0.466822452446523 no 1567 0.370884222922619 1626 24762078
SGTC_2644 guaiazulene 100 µM 0.329246608180313 0.466927892448212 no 1568 0.370984648357015 1818 3515 A coloring agent.
SGTC_1000 4048-0884 8.67 µM 0.329045532424232 0.467007670122286 no 1569 0.371060636296026 1770 13040088
SGTC_1156 4092-0367 4.88 µM 0.328225130301275 0.46733318190729 no 1570 0.371370724090442 1752 1357585
SGTC_1292 0kpi-0043 232 µM 0.328026657062224 0.467411933626469 no 1571 0.371445753670717 1708 3333905
SGTC_1540 guanosine 70.6 µM 0.327990439197291 0.467426304563701 no 1572 0.371459445772665 1824 6802 Guanosine is a purine nucleoside
SGTC_952 1185-0122 232 µM 0.32610890226929 0.468172940190643 no 1573 0.372170980929252 1697 678600
SGTC_679 0422-0091 41.4 µM 0.325911284694204 0.46825136577497 no 1574 0.372245738754988 1675 627384 YHR062C RPP1
SGTC_2249 haloperidol 116.36 µM 0.325588516774411 0.468379460586674 no 1575 0.37236785073765 1789 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_484 loperamide 105 µM 0.324758205191938 0.468708995972418 no 1576 0.372682039391733 1752 3955 An opioid-receptor agonist.
SGTC_395 anisomycin 6.25 µM 0.32420686530979 0.468927824483156 no 1577 0.372890712397825 1740 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_42 0133-0086 60.653 µM 0.323742876393629 0.469111990401192 no 1578 0.37306635341987 1653 162923 Model of phenazepam hydroxylation.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.322893239391064 0.469449244393705 no 1579 0.37338804824852 1827 17037758
SGTC_2922 7999257 32.47 µM 0.321369254413957 0.470054228103109 no 1580 0.37396528990176 1731 2988377
SGTC_2071 5230951 39.92 µM 0.321251334125423 0.470101042391521 no 1581 0.374009966515804 1819 1799272
SGTC_1740 st038286 13.222 µM 0.320876310632669 0.470249929251795 no 1582 0.374152063405094 1779 716786
SGTC_261 5-fluorouridine 15.376 µM 0.320566093054394 0.470373090870271 no 1583 0.374269618173048 1830 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1463 k081-0032 34.1 µM 0.320073140832439 0.470568807054226 no 1584 0.374456442992924 1665 977755
SGTC_2000 st075254 36.4 µM 0.319279557990961 0.470883897139774 no 1585 0.374757266246141 1727 17234175
SGTC_2915 7971052 15.16 µM 0.318949297619663 0.471015031578333 no 1586 0.374882480437404 1818 5741558
SGTC_904 1141-0088 396 µM 0.317463201758815 0.471605145135403 no 1587 0.37544607859326 1691 1378119
SGTC_1172 0370-0043 85 µM 0.315097578168962 0.472544638298083 no 1588 0.376343783636707 1790 376585
SGTC_2090 5301565 104.445 µM 0.313668558503143 0.473112239202031 no 1589 0.376886391543991 1762 2056344
SGTC_310 1273-0058 1.06 µM 0.313663630594318 0.47311419664286 no 1590 0.376888263123968 1780 2734232
SGTC_800 3448-7362 155 µM 0.313487993470664 0.473183962820858 no 1591 0.376954970573904 1790 15991913
SGTC_1782 st039423 80.636 µM 0.311795808993385 0.473856170308498 no 1592 0.377597854663703 1710 2068169
SGTC_2846 9008642 19.48 µM 0.311680914396822 0.473901814038658 no 1593 0.377641517015668 1727 2992898
SGTC_3062 9077494 49.47 µM 0.311081882911053 0.474139794486664 no 1594 0.377869186836746 1829 16459633
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.310722320292995 0.474282644292021 no 1595 0.378005863736776 1857 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1286 0929-0070 131 µM 0.308968029983234 0.474979649335522 no 1596 0.378672923076333 1833 1420408
SGTC_2531 methyl deoxycholate 70.07 µM 0.307337039924734 0.475627734139748 no 1597 0.379293422627525 1722 16667744 Haematoxylin.
SGTC_1786 berberine 21.6 µM 0.305842708462058 0.476221573386651 no 1598 0.379862204444521 1716 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_606 k015-0008 38.6 µM 0.305142037438662 0.476500034533088 no 1599 0.380128987855404 1879 1970475
SGTC_460 trequinsin 123 µM 0.304866171883081 0.476609672362768 no 1600 0.380234040472682 1798 5537 A vasodilator.
SGTC_2769 toremifene 3.73 µM 0.304396737767941 0.476796244619195 no 1601 0.380412826418312 1801 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_186 3455-3465 67.277 µM 0.304287207791808 0.476839777030668 no 1602 0.380454545045098 1780 755278
SGTC_57 miconazole 162.5 nM 0.301380852387245 0.477994999980415 no 1603 0.381562046769724 1703 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2398 5228213 48.84 µM 0.299897730647217 0.478584585530527 no 1604 0.382127582694373 1956 80771 YMR134W ERG29
SGTC_2541 muurolladie-3-one 83.07 µM 0.29942563154221 0.478772269035258 no 1605 0.382307653804397 1821 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1219 1469-0211 33.1 µM 0.297651183833865 0.479477744377031 no 1606 0.382984702541495 1885 6822282
SGTC_1851 st056236 18.9 µM 0.297416460500695 0.479571069275588 no 1607 0.383074289144785 1905 5393171
SGTC_2612 dictamnine 15.46 µM 0.296412237838554 0.479970356087585 no 1608 0.383457640296297 1788 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2477 5967686 25.23 µM 0.296406819914081 0.479972510351748 no 1609 0.383459708840271 1739 776118
SGTC_850 0388-0143 75.9 µM 0.295904827734081 0.480172113996034 no 1610 0.383651382044986 1777 67273
SGTC_1903 st060211 78.3 µM 0.295833748002917 0.480200377336062 no 1611 0.383678524371407 1900 688960
SGTC_3353 9151644 39.2805 µM 0.29485451604706 0.48058975812109 no 1612 0.384052509449342 1796 4909158
SGTC_1886 st057356 49.9 µM 0.293041624031267 0.481310683239293 no 1613 0.384745168062194 1728 24207747
SGTC_2372 9071633 200 µM 0.291956679974171 0.481742157752227 no 1614 0.385159872989729 1912 21321366
SGTC_1294 1000-1494 117 µM 0.291540607079201 0.481907632676211 no 1615 0.385318946002701 1747 712797 YDL207W GLE1
SGTC_2873 9040596 71.43 µM 0.291313810138841 0.481997832623904 no 1616 0.385405663149614 1737 6463863
SGTC_1422 4031-0024 15.5 µM 0.288701173619126 0.483036975762398 no 1617 0.386405032254619 1898 782427
SGTC_894 0960-0238 55.9 µM 0.288635597174799 0.48306305947594 no 1618 0.386430125866308 1911 6741907 YDL195W SEC31
SGTC_696 1560-0013 611 µM 0.287213966644251 0.483628545453222 no 1619 0.386974246405847 1853 1650269
SGTC_3105 9121040 49.47 µM 0.286337402251758 0.483977235424195 no 1620 0.387309856971831 1919 41448907
SGTC_3268 9137683 49.47 µM 0.285672105870318 0.48424189294456 no 1621 0.387564635517105 1794 1953228
SGTC_1654 st012436 41.8 µM 0.285252384883547 0.48440886318478 no 1622 0.387725394667814 1905 4323132
SGTC_3126 9127922 49.47 µM 0.284813757179295 0.48458335767383 no 1623 0.387893415930133 1843 45595682
SGTC_1082 camptothecin 424.86 nM 0.284802020045647 0.484588026970762 no 1624 0.38789791225934 1562 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2732 terfenadine 20 µM 0.283768141108332 0.484999335588781 no 1625 0.388294035504764 1844 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_852 0418-0143 439 µM 0.282741482512598 0.48540778752931 no 1626 0.388687507347032 1910 5369229
SGTC_2754 granisetron 64.02 µM 0.282293152452327 0.485586158645637 no 1627 0.388859367854483 1921 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1819 st053448 58.6 µM 0.281649387091794 0.485842290039453 no 1628 0.389106183544822 1831 2857616
SGTC_2105 5350118 200 µM 0.280252278739741 0.486398169829074 no 1629 0.389641980151231 1783 2133313
SGTC_3107 9121808 49.47 µM 0.280150838246218 0.486438531892714 no 1630 0.389680891165961 1929 662681
SGTC_541 4513-1321 94 µM 0.27980109469538 0.486577692091523 no 1631 0.389815055894877 1767 747515
SGTC_801 0866-0028 10.1 µM 0.278943125477952 0.486919078160275 no 1632 0.390144236078782 1818 6849771
SGTC_487 nimodipine 119 µM 0.277297035430084 0.48757408423923 no 1633 0.390776017865207 1920 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2021 4019055 173 µM 0.276901809537201 0.487731356125246 no 1634 0.390927751548108 1850 44827708 YER133W GLC7
SGTC_2925 9010536 32.5 µM 0.275792892615567 0.488172636551871 no 1635 0.391353571480046 1872 2994177
SGTC_1664 st014217 9.02 µM 0.275208001575283 0.488405392918767 no 1636 0.391578219939827 1926 3982782
SGTC_1405 3909-7894 12 µM 0.274670347529556 0.488619354891662 no 1637 0.3917847572338 1917 7104060
SGTC_977 1348-1378 135 µM 0.274292239950006 0.488769826558315 no 1638 0.391930023768892 1831 X977
SGTC_3092 9117248 49.47 µM 0.273996153775899 0.488887658109084 no 1639 0.392043788719576 1912 17141857
SGTC_135 0933-0004 26.348 µM 0.273987419703738 0.488891133967576 no 1640 0.392047144745234 1762 21230617 YGL099W LSG1
SGTC_1904 st060225 78 µM 0.273731214412185 0.488993095182345 no 1641 0.392145593981231 1783 66595
SGTC_1109 tnp00067 928.257 nM 0.273403448340834 0.489123536263659 no 1642 0.392271551169944 1804 676295
SGTC_1742 st038235 28.8875 µM 0.272645804494647 0.489425060255791 no 1643 0.392562749224832 1825 564103 YBR002C RER2
SGTC_583 1488-1091 88.9 µM 0.272534136502491 0.489469501940737 no 1644 0.392605673560644 1979 4303273
SGTC_683 panaxydol 45 µM 0.271830298040434 0.489749618920419 no 1645 0.392876253814267 1918 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_209 4077-0173 175.592 µM 0.271651989458756 0.489820583826192 no 1646 0.392944810127274 1852 15993494
SGTC_1075 aripiprazole 15.2 µM 0.27053555763411 0.490264918970805 no 1647 0.393374132680784 1810 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1381 2324-0066 62.1 µM 0.270308536909312 0.490355273755221 no 1648 0.393461449118487 1845 10885928
SGTC_2639 lactacystin 53 µM 0.27008550334403 0.490444042122731 no 1649 0.39354723723778 1913 3870 A proteasome inhibitor.
SGTC_742 0kpi-0133 140 µM 0.268723704083756 0.490986054491433 no 1650 0.394071154651625 1948 2728852
SGTC_1729 st035615 45.989 µM 0.268168991881102 0.491206841400192 no 1651 0.394284620991057 1801 17385451
SGTC_924 2046-0044 21.3 µM 0.268091267455465 0.491237777542966 no 1652 0.394314533721275 1765 3623589
SGTC_1288 0973-0013 65.5 µM 0.268027580959336 0.491263126300131 no 1653 0.394339044331338 1848 4315430
SGTC_3169 9102970 49.47 µM 0.267154853255559 0.491610496427066 no 1654 0.394674967512444 1873 17027839
SGTC_393 acivicin 6.25 µM 0.267044499195751 0.49165442089953 no 1655 0.394717449674442 1848 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_521 r062-0005 13.8 µM 0.266690401878148 0.491795363725017 no 1656 0.394853772273355 1789 2832033
SGTC_287 k060-0039 29.6 µM 0.265211011794049 0.492384222380744 no 1657 0.395423456186858 1949 5861974
SGTC_2996 9066192 71.4286 µM 0.263980423050103 0.492874060476321 no 1658 0.39589750199029 1746 6472854
SGTC_2787 5284540 71.43 µM 0.262334893692366 0.493529083102201 no 1659 0.396531631238161 1815 736958
SGTC_2507 purpurin 79.67 µM 0.261815906735997 0.493735675765251 no 1660 0.396731687462604 1738 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1914 st062367 72.6 µM 0.261681927444218 0.493789009054479 no 1661 0.396783337476641 1809 978205
SGTC_2681 menadione 3.18 µM 0.26117027848887 0.493992682750002 no 1662 0.396980598611531 1870 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3140 9094243 49.47 µM 0.260844072601444 0.494122537365913 no 1663 0.397106377791353 2044 19291112
SGTC_1354 1498-1681 81 µM 0.26039238762352 0.494302343175821 no 1664 0.397280557140971 1851 5754243
SGTC_1165 k072-0275 30.3 µM 0.260022437993833 0.494449612813461 no 1665 0.397423232862424 1945 6153523 YGL055W OLE1
SGTC_97 0535-0701 19.132 µM 0.259796374480708 0.494539604604822 no 1666 0.397510423852992 1789 2832013 YGL099W LSG1
SGTC_2114 5491910 81.25 µM 0.259604805481921 0.494615864972299 no 1667 0.397584314578378 1904 2849228
SGTC_750 4073-0104 132 µM 0.258547991106553 0.495036568302325 no 1668 0.397992008006033 1913 22330957
SGTC_718 1130-0073 349 µM 0.256220654918129 0.495963067770162 no 1669 0.398890230260382 1909 6740020
SGTC_1522 st012842 45.6 µM 0.255824443808081 0.496120799494973 no 1670 0.399043199195629 1749 3491067 YOR116C RPO31
SGTC_2226 7298446 200 µM 0.254272323727657 0.496738704429966 no 1671 0.399642589873947 1954 3283010
SGTC_2835 9006588 71.43 µM 0.253453050412779 0.497064863516241 no 1672 0.399959068610002 1801 2345538
SGTC_122 0236-0016 402.397 µM 0.253402260316611 0.497085083515853 no 1673 0.399978690583924 1862 6808838
SGTC_2464 5717415 7.67 µM 0.253117135798278 0.497198594319536 no 1674 0.400088848751225 1775 5285744
SGTC_302 1094-0063 18.9 µM 0.252612558190179 0.497399472051772 no 1675 0.400283812336923 1846 5440289
SGTC_3206 9114350 49.47 µM 0.252137830073507 0.497588466985739 no 1676 0.400467265078072 1955 17087243
SGTC_842 0271-0008 11.1 µM 0.249248898321927 0.498738595343233 no 1677 0.401584128630392 1925 1221709
SGTC_2338 7999974 200 µM 0.246143626178517 0.499974863577814 no 1678 0.402785526450384 2021 315925
SGTC_2322 7413319 38.22 µM 0.246017350509912 0.499974863577814 no 1679 0.402834400717639 1864 1840400
SGTC_2440 5628896 157.78 µM 0.245889854429946 0.499924104863918 no 1680 0.402883748878485 1858 5522048
SGTC_2693 st077581 40.7 µM 0.244715475336723 0.499456561457386 no 1681 0.403338372362946 1991 25238761
SGTC_1329 1447-1697 50.6 µM 0.244322185279459 0.499299985088111 no 1682 0.403490651327273 1892 2840515
SGTC_1245 0418-0076 17.2 µM 0.243453907120889 0.498954307196202 no 1683 0.403826893909445 1896 6790114
SGTC_2601 securinine 100 µM 0.242892711848696 0.498730885187742 no 1684 0.404044255818709 1840 442872 A GABA receptor antagonist.
SGTC_1761 st044296 37 µM 0.242729274906635 0.498665818050852 no 1685 0.404107563718271 1862 1826700
SGTC_2369 9071472 200 µM 0.242338459732857 0.498510227766065 no 1686 0.404258957590979 1908 17296037
SGTC_2817 7995342 71.43 µM 0.242132234730369 0.498428126113131 no 1687 0.404338850755702 1811 18879975
SGTC_2210 7115885 190.385 µM 0.241843769720616 0.498313283438212 no 1688 0.404450611029203 1898 2927039
SGTC_2340 7987427 183.45 µM 0.241830844078644 0.498308137530301 no 1689 0.404455619005563 1918 2239331
SGTC_1302 1159-0335 255 µM 0.241093243198656 0.498014487138234 no 1690 0.404741424746193 1853 649284
SGTC_571 k831-0106 44.2 µM 0.240370966564103 0.497726938608227 no 1691 0.405021341902489 2009 4783639
SGTC_1272 0839-0021 27 µM 0.240171584049892 0.497647561814783 no 1692 0.405098620843306 1903 5027250
SGTC_421 streptovitacin 30 mM 0.239435265124064 0.497354424426417 no 1693 0.405384043746789 1834 91467 include heat shock
SGTC_1913 st060213 96.1 µM 0.238919536932845 0.497149107694246 no 1694 0.405583987962712 2004 688959
SGTC_1400 3771-8998 51.5 µM 0.238514309818777 0.496987783111933 no 1695 0.405741108970858 1929 670767
SGTC_1214 0358-0031 63.7 µM 0.238508294892019 0.496985388518787 no 1696 0.405743441286983 2015 4301366
SGTC_1206 3978-0017 132 µM 0.237812888414626 0.49670854208096 no 1697 0.406013110952319 1940 3873677
SGTC_2121 5257820 149.641 µM 0.236937342169808 0.496359982946238 no 1698 0.406352699909014 2022 791256
SGTC_1465 k213-0056 144 µM 0.236908962564605 0.49634868493515 no 1699 0.40636370838959 1866 24048857 YMR208W ERG12
SGTC_509 pifithrin 175 µM 0.236678227870693 0.496256828829188 no 1700 0.406453213381621 1921 4817 A p53 inhibitor.
SGTC_1731 st035964 63 µM 0.235368848859762 0.495735565404338 no 1701 0.406961230990616 1834 6739575
SGTC_3273 9137859 49.47 µM 0.233421094876213 0.49496017881643 no 1702 0.407717217098657 2028 2377234
SGTC_595 3909-8003 73.7 µM 0.233005773711588 0.494794844867673 no 1703 0.407878461191041 1923 699517
SGTC_1164 k060-0068 93.7 µM 0.232716945813943 0.494679866767139 no 1704 0.407990604798332 1928 5963676
SGTC_2816 7982706 58.44 µM 0.232278477335507 0.494505319819596 no 1705 0.408160863965773 1865 2981853
SGTC_2328 6201408 200 µM 0.23088617127181 0.493951073260829 no 1706 0.408701617117884 1865 2890418
SGTC_313 3474-0040 5.03 µM 0.23061234356785 0.493842069787832 no 1707 0.408807988645646 1873 1043375 YIL048W NEO1
SGTC_1515 3460-0031 42.1 µM 0.229850241341106 0.493538699754431 no 1708 0.409104071379752 1955 2876596
SGTC_78 0336-0123 156.75 µM 0.229260186340373 0.493303819117944 no 1709 0.409333348042608 1818 6765896
SGTC_2521 angolensin 13.4 µM 0.228350792527483 0.49294182523966 no 1710 0.409686770355617 1924 821428 A flavenoid.
SGTC_1229 0139-0193 12.2 µM 0.227883139150722 0.492755673083998 no 1711 0.409868545446163 2028 3090752
SGTC_3160 9100216 49.47 µM 0.227525661913468 0.492613378245361 no 1712 0.410007508556247 2031 17191039
SGTC_3288 9119690 36.221 µM 0.227371742548119 0.492552110489355 no 1713 0.410067345536783 1845 17595618 YKL019W RAM2
SGTC_763 3453-1109 128 µM 0.225049668725648 0.491627828844915 no 1714 0.410970317555875 2012 1560353
SGTC_804 1595-0054 20.9 µM 0.224928161067951 0.491579464954429 no 1715 0.411017580603092 1893 761523 Stimulates phospholipase C.
SGTC_1703 st026983 48.3 µM 0.223305885524922 0.490933760123207 no 1716 0.411648723464316 2031 1104023
SGTC_2870 9038528 12.99 µM 0.222559613372816 0.490636733666147 no 1717 0.411939135953305 1917 6463316
SGTC_1916 st067606 49.2 µM 0.222277622092515 0.490524498647587 no 1718 0.412048885683372 1974 19590279
SGTC_955 1216-0110 33 µM 0.222221263723896 0.490502067609099 no 1719 0.412070820930483 1865 3619719
SGTC_1590 st077108 57.8 µM 0.222033259014179 0.490427240591968 no 1720 0.412143996251494 2016 5489485
SGTC_1378 2093-0007 380 nM 0.220317505145713 0.489744376020447 no 1721 0.412811943974689 1890 3618014
SGTC_107 0358-0022 2.6945 µM 0.220125453267465 0.489667941818787 no 1722 0.412886726052149 2014 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1670 st016595 4.04 µM 0.219938583160571 0.489593570260324 no 1723 0.412959493461473 2037 597879
SGTC_2437 5741531 144.16 µM 0.219899316727362 0.489577942842427 no 1724 0.412974784230757 2033 2262990
SGTC_2519 cryptotanshinone 88.04 µM 0.219736693001663 0.489513221348407 no 1725 0.413038113055272 1986 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2354 9060492 162 µM 0.219692908576702 0.489495795934466 no 1726 0.41305516394404 2004 6471895
SGTC_8 0354-0001 70 µM 0.219629079269394 0.489470393053661 no 1727 0.413080021168613 1922 4993152
SGTC_614 0462-0418 107 µM 0.219338035191512 0.489354563450072 no 1728 0.413193367688439 1961 5188303
SGTC_2408 sulbentine 18.36 µM 0.21775239076869 0.488723525352858 no 1729 0.413811020521971 1939 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2696 st077691 74.316 µM 0.217374850622389 0.488573279996116 no 1730 0.413958114458613 1938 757133
SGTC_921 1561-0023 372 µM 0.217292228131544 0.488540399878959 no 1731 0.413990306731863 1833 24050882
SGTC_2774 tamoxifen 10.92 µM 0.217095456055498 0.488462093561867 no 1732 0.41406697753458 1969 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.215698328224975 0.487906113335257 no 1733 0.414611452214884 1881 6708561
SGTC_2624 nerol 100 µM 0.21547080593735 0.487815574144024 no 1734 0.414700135489754 1974 637566 A natural product oil.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.215261917689706 0.487732450651276 no 1735 0.414781559446518 1907 688788
SGTC_2232 chlorophetanol 41.5365 µM 0.214755927660123 0.487531102819896 no 1736 0.414978807877044 1991 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_882 0843-0131 351 µM 0.212575727109592 0.486663575976702 no 1737 0.415828952842125 2054 5425421
SGTC_2023 5144124 124 µM 0.21247446588805 0.486623284475366 no 1738 0.415868448136614 1916 2830192
SGTC_2358 9037157 4 µM 0.212199597202996 0.486513915834574 no 1739 0.415975660484878 1930 2388925
SGTC_2394 5221648 200 µM 0.211617625518368 0.48628235606537 no 1740 0.416202678781987 2003 788586
SGTC_3178 9107506 49.47 µM 0.210978596495202 0.486028099174746 no 1741 0.416451986482276 1981 8897194
SGTC_138 0850-0259 40.9225 µM 0.208988034452178 0.48523613114586 no 1742 0.417228789750385 2036 6813004
SGTC_651 3253-0966 34.4 µM 0.208531262854174 0.485054407407402 no 1743 0.41740708745364 1921 781462
SGTC_1976 st070609 63.5 µM 0.208396462374553 0.485000778466734 no 1744 0.417459709156238 2008 682556
SGTC_293 4049-0273 38.5 µM 0.208185987670825 0.484917043881732 no 1745 0.417541874558911 1982 1380311
SGTC_1852 st056254 31.4 µM 0.207082764903164 0.484478152218607 no 1746 0.41797261098613 1967 442583
SGTC_826 1683-5028 118 µM 0.206016405824337 0.484053943788213 no 1747 0.418389048094863 1934 722377
SGTC_392 N-ethylmaleimide 8.33 µM 0.205713914104001 0.483933612786576 no 1748 0.418507194566221 1913 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1397 3532-0190 20.1 µM 0.205208813171792 0.483732687244627 no 1749 0.418704492027514 1953 5322280
SGTC_833 3852-0053 558 µM 0.205178030348005 0.483720442190294 no 1750 0.418716516767125 1983 3123681
SGTC_2383 9036125 200 µM 0.203106604484701 0.482896488599105 no 1751 0.419525854844018 1946 79580
SGTC_1516 st013856 110 µM 0.203105978302708 0.482896239532796 no 1752 0.419526099554654 1966 5281404 A mutagen and neurotoxin.
SGTC_2318 6029776 164 µM 0.203062946797379 0.482879123601181 no 1753 0.419542916253081 1989 818325
SGTC_767 0929-0023 86 µM 0.202569023844873 0.482682666288341 no 1754 0.419735951699749 2035 1204563
SGTC_979 1426-2828 121 µM 0.202541152477373 0.482671580607355 no 1755 0.419746844990718 2004 747872
SGTC_3257 9139206 32.98 µM 0.202374141315114 0.482605153129938 no 1756 0.419812121195168 2033 4910041
SGTC_2529 gangaleoidin 93.61 µM 0.201903588928458 0.482417996936883 no 1757 0.419996048149764 1958 4565183
SGTC_1030 k029-0042 36.7 µM 0.201795180507876 0.48237487942186 no 1758 0.420038424721067 1943 6080581
SGTC_60 0986-0278 202 µM 0.20080082404714 0.481979401562558 no 1759 0.420427159278549 1769 3110598
SGTC_2414 st077232 92.9 µM 0.200492504988579 0.481856779743405 no 1760 0.420547709576018 1809 729801
SGTC_805 3852-0218 479 µM 0.200230815861315 0.481752704497694 no 1761 0.420650033788763 1892 6615355
SGTC_1652 st011932 78 µM 0.199828259150005 0.481592607847601 no 1762 0.420807449718605 2032 1551076
SGTC_1079 idarubicin 2.36 µM 0.199171744247063 0.481331518501888 no 1763 0.421064200712098 2076 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.198608437371174 0.48110750342565 no 1764 0.421284526514802 1905 5282362
SGTC_2217 6934799 96.0675 µM 0.198159316501889 0.480928901948835 no 1765 0.42146020849424 2058 675606
SGTC_3190 9110366 49.47 µM 0.196050449915876 0.480090322720023 no 1766 0.422285339394158 2066 17123768
SGTC_2253 7938677 135.83 µM 0.194234750584281 0.47936839028967 no 1767 0.422996036975482 2088 2301972
SGTC_1746 st038117 42 µM 0.192635037720172 0.478732391315392 no 1768 0.423622401348451 1926 2898218
SGTC_2452 5863136 48.41 µM 0.191876524409718 0.478430847468189 no 1769 0.423919463282156 1982 2184096
SGTC_807 1315-0151 48 µM 0.191783346317234 0.478393805748738 no 1770 0.423955958262973 2099 4011080
SGTC_2815 7968870 71.43 µM 0.191538698311423 0.478296550055838 no 1771 0.424051782433697 1949 2977326 YHR190W ERG9
SGTC_1420 4'-methoxyflavone 42 µM 0.191026705079887 0.478093019961932 no 1772 0.424252335388496 2072 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.190918665950396 0.478050072438456 no 1773 0.424294657922147 1934 6857784
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.189129007010566 0.477338687843387 no 1774 0.424995853715079 2046 88881 An O-methylated flavonoid and antioxidant.
SGTC_448 monastrol 171 µM 0.188064460546062 0.476915567602718 no 1775 0.425413060167815 2057 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3088 9117578 49.47 µM 0.188044614540902 0.476907679750675 no 1776 0.425420838811175 2083 678341
SGTC_298 1391-0729 10 µM 0.186333423647383 0.476227596341822 no 1777 0.426091649068283 1953 3237558
SGTC_3013 9080133 71.4286 µM 0.18574096063171 0.475992148135755 no 1778 0.42632395263289 2027 17050193
SGTC_1427 4048-4900 550 nM 0.185164706536874 0.475763149488583 no 1779 0.426549925238313 2097 24132586
SGTC_65 0798-0905 34.986 µM 0.184917930035649 0.475665084976386 no 1780 0.426646703692933 2089 3602145
SGTC_861 0443-0273 110 µM 0.184510637352264 0.475503237467356 no 1781 0.426806441509961 2021 6149169
SGTC_2991 9074669 71.4286 µM 0.184509614020324 0.475502830826963 no 1782 0.426806842869914 2044 17333109
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.184435600431643 0.475473420188721 no 1783 0.426835871863296 2009 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3134 9127454 49.47 µM 0.184179343788683 0.475371593009717 no 1784 0.426936381769906 2115 24262820
SGTC_612 0302-0167 22.4 µM 0.183861554697197 0.475245317282461 no 1785 0.427061032744463 2048 235821
SGTC_2725 haloperidol 53.21 µM 0.183126323930681 0.474953177726238 no 1786 0.427349450754083 2069 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2969 9091408 28.7 µM 0.182859965192903 0.47484734498644 no 1787 0.427453948161 1844 4286311
SGTC_3086 9117350 49.47 µM 0.182788590719397 0.474818985954864 no 1788 0.42748195053801 2064 2679265
SGTC_1783 st039459 87.517 µM 0.181602332151641 0.47434767175295 no 1789 0.427947409246621 2092 729761
SGTC_735 3076-0345 636 µM 0.181443008432075 0.474284373322936 no 1790 0.428009931611476 2065 2888990
SGTC_1832 st054113 55 µM 0.180997915126296 0.474107543666545 no 1791 0.428184606238123 2099 1251267
SGTC_2028 5153890 36.43 µM 0.176905974275911 0.472482113405335 no 1792 0.429791122922815 1988 2830968 YPR165W RHO1
SGTC_1827 berberine 7.24 µM 0.176650981943377 0.472380838396523 no 1793 0.429891272979211 1861 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.176338068149672 0.472256561228891 no 1794 0.430014178266571 2079 6728940
SGTC_693 4161-2696 114 µM 0.173121626888485 0.470979274805039 no 1795 0.431277912909219 2069 805759
SGTC_3004 9076122 71.4286 µM 0.172042751278679 0.470550906886643 no 1796 0.431701959693534 2071 44782551
SGTC_1754 st042065 16.137 µM 0.171392493482152 0.470292738239305 no 1797 0.431957578391505 2019 1126236 YIL048W NEO1
SGTC_510 ag-490 170 µM 0.170517202745715 0.469945245608665 no 1798 0.432301703320505 2138 5328779
SGTC_2420 aureobasidin a 50 nM 0.169630414475589 0.469593211769948 no 1799 0.432650400942927 2099 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1301 naphtanilide LB 4.81 µM 0.169503589438759 0.46954286718481 no 1800 0.432700274625282 2101 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2395 5646831 180.19 µM 0.168891606537497 0.469299940738508 no 1801 0.432940950685554 2039 6808628
SGTC_2973 9094665 17.96 µM 0.168544421405347 0.469162130769481 no 1802 0.433077500124279 2095 25237061 YIL048W NEO1
SGTC_1086 cerivastatin 2.18 µM 0.168261877255316 0.46904998180181 no 1803 0.433188631878778 2122 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2923 7992654 58.14 µM 0.167775037077931 0.468856748304789 no 1804 0.433380130813844 1981 2985126
SGTC_1276 0871-0068 94.2 µM 0.167630703146609 0.468799461609476 no 1805 0.433436907678029 2083 3414906
SGTC_2285 7945142 200 µM 0.167005385720815 0.468551278182811 no 1806 0.433682905624702 2002 2970608
SGTC_1461 k072-0203 53.8 µM 0.166160712561509 0.468216053661803 no 1807 0.434015238213371 2127 5418714
SGTC_2001 4023502 57.655 µM 0.166028652469813 0.468163645147461 no 1808 0.434067200843217 2037 108941 YCR052W RSC6
SGTC_1924 st058459 75.1 µM 0.164738717001262 0.46765175885103 no 1809 0.434574820768765 2072 688683
SGTC_3049 9092223 49.47 µM 0.163979961493863 0.467350686123972 no 1810 0.434873459339332 2029 8623917
SGTC_3076 9116187 49.47 µM 0.163284746174702 0.467074842413911 no 1811 0.435147121753834 2117 27241210
SGTC_3251 9135047 49.47 µM 0.163029566246424 0.466973597485744 no 1812 0.43524757779523 2099 17682963
SGTC_678 1218-2179 85.9 µM 0.161405269529672 0.466329193539298 no 1813 0.435887108303176 2128 6820081 YOR116C RPO31
SGTC_1295 1013-0063 9.78 µM 0.161062240677701 0.466193115628783 no 1814 0.436022189743781 2132 6826038
SGTC_1911 st060208 74.3 µM 0.160761012809887 0.466073623227982 no 1815 0.436140816516602 2087 688783
SGTC_1357 1503-1303 39.5 µM 0.159167035590241 0.46544136847091 no 1816 0.436768637261118 2060 292895
SGTC_75 0159-0059 199.013 µM 0.157645621456448 0.464837977366267 no 1817 0.437368026153105 2109 5377270
SGTC_4 0960-0234 25.671 µM 0.157629369678074 0.464831532363505 no 1818 0.437374429616618 2020 6821112
SGTC_1860 st056228 74.6 µM 0.157167461822345 0.464648356434168 no 1819 0.43755643563457 2002 688679
SGTC_1828 st055811 49 µM 0.156193436601363 0.464262117904582 no 1820 0.437940275037738 2139 5877589
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.155930450208372 0.464157839425339 no 1821 0.438043921539939 2151 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2845 9003024 42.97 µM 0.155078731142314 0.46382013558375 no 1822 0.438379624706355 2108 2990173
SGTC_3037 9091026 49.47 µM 0.151426693973431 0.462372413222592 no 1823 0.439819566753198 2125 25236398 YIL048W NEO1
SGTC_519 k048-0011 62.8 µM 0.151362471665038 0.46234695893799 no 1824 0.439844895802729 2019 6836379
SGTC_1619 st003326 88.7 µM 0.150268462954929 0.461913376229746 no 1825 0.440276406676496 2145 2849032
SGTC_2201 6605497 169.863 µM 0.149925395174899 0.461777419281323 no 1826 0.440411737855891 2112 670741
SGTC_1986 st071812 45 µM 0.149537571171113 0.461623730926674 no 1827 0.440564732565086 2148 11838594
SGTC_445 e6 berbamine 66 µM 0.148822877940392 0.461340524633057 no 1828 0.440846698842168 2048 6610268 A calcium/calmodulin antagonist.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.147113523344685 0.460663250889778 no 1829 0.441521207965994 2048 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_153 4077-0274 519.67 µM 0.146757160243923 0.46052206841348 no 1830 0.441661849820678 2153 3121976
SGTC_3149 9097855 49.47 µM 0.146458798038764 0.460403868321604 no 1831 0.44177960676607 2136 25236625 YMR079W SEC14
SGTC_1039 k821-0043 94 µM 0.14617880959861 0.460292950419197 no 1832 0.441890116674344 2138 15992768
SGTC_458 nppb 133 µM 0.145436263349092 0.459998804430049 no 1833 0.4421832175054 2159 4549 A chloride channel blocker.
SGTC_624 k048-0052 28 µM 0.144248230274921 0.45952823265646 no 1834 0.442652228453062 2040 6835531
SGTC_2327 6189656 200 µM 0.143418279687786 0.459199528503361 no 1835 0.442979923552611 2122 5349088
SGTC_486 niguldipine 82 µM 0.143315798241834 0.459158942382241 no 1836 0.443020389717072 2080 1236 A calcium channel blocker.
SGTC_809 3998-0021 90 µM 0.142705502417245 0.458917253409851 no 1837 0.443261385449724 2173 715485
SGTC_1579 chlormadinone acetate 49.4 µM 0.142001025333177 0.458638285719899 no 1838 0.443539597897797 2159 45114258 A steroidal progestin.
SGTC_2506 ethyl hematommate 54.16 µM 0.139350057553356 0.457588705849555 no 1839 0.444586767752945 1972 3940691 An allergen.
SGTC_3115 9123671 49.47 µM 0.138459458493744 0.457236162942039 no 1840 0.444938654191381 2184 3286988
SGTC_2136 5328288 199.296 µM 0.138341122230541 0.45718932215588 no 1841 0.444985413549342 2052 262395
SGTC_147 4466-0538 29.23 µM 0.138109525391961 0.457097651403619 no 1842 0.445076928873903 2059 6742687 YHR072W ERG7
SGTC_2958 9077254 16.72 µM 0.136506290228782 0.456463121088575 no 1843 0.445710526107746 2061 16457351
SGTC_2188 6126565 140.678 µM 0.136144178120617 0.456319819238314 no 1844 0.445853651774328 2139 874518
SGTC_1803 st050068 52.4 µM 0.134771485200738 0.455776642984622 no 1845 0.446396275813049 2170 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2058 5236698 133 µM 0.134711857320708 0.455753050025856 no 1846 0.446419848932536 2082 766665
SGTC_2176 5809774 33.9695 µM 0.134412483080791 0.455634599002954 no 1847 0.446538205568324 2177 2870539
SGTC_822 1487-0950 154 µM 0.13277084705998 0.454985136322725 no 1848 0.447187305437997 2188 1958375
SGTC_2048 5246248 200 µM 0.132702546247711 0.454958117806822 no 1849 0.447214314531628 2183 677046
SGTC_2334 9017922 200 µM 0.131682174076597 0.454554502656258 no 1850 0.447617842874378 2144 3163164
SGTC_2031 5180455 200 µM 0.13158810803743 0.454517296550491 no 1851 0.447655046069247 2166 29949
SGTC_667 1498-1044 59 µM 0.130036403648987 0.453903606013447 no 1852 0.448268812626713 2088 6739982
SGTC_3321 9137793 26.8275 µM 0.130028324328646 0.453900410973468 no 1853 0.448272008674602 2183 4904192
SGTC_1753 st043925 64 µM 0.12968292924564 0.45376382417049 no 1854 0.448408644496204 2166 670181
SGTC_2902 5787006 60.46 µM 0.129274238350869 0.453602214045364 no 1855 0.448570327591893 2082 591003
SGTC_1012 4112-3522 18 µM 0.128599096564636 0.453335257118163 no 1856 0.448837440604892 2176 3112398
SGTC_1418 3966-3099 2.4 µM 0.127670407015914 0.452968079678795 no 1857 0.449204905091607 2150 740335
SGTC_530 4358-1714 28 µM 0.127330824843814 0.452833828567216 no 1858 0.449339282082516 2116 1564641
SGTC_2246 7293507 91.5585 µM 0.127252013861149 0.452802672042129 no 1859 0.449370469423503 2197 887656
SGTC_922 1866-0035 480 µM 0.126889574509126 0.452659391812332 no 1860 0.449513899138404 2032 3156169
SGTC_337 1315-0038 354 µM 0.125044329744498 0.451930022029504 no 1861 0.450244227834985 2079 1626437
SGTC_1023 4482-3888 16 µM 0.124671733779539 0.451782765650736 no 1862 0.450391717974934 2180 3303168
SGTC_601 0986-0029 62.9 µM 0.1218309367604 0.450660253022663 no 1863 0.451516456226339 2100 24747981
SGTC_1034 k072-0165 12.7 µM 0.121558051404774 0.450552445721659 no 1864 0.451624518584731 2185 5835461
SGTC_928 2764-0428 58.7 µM 0.121548864447339 0.45054881634487 no 1865 0.45162815667413 2106 662578
SGTC_3110 9122132 49.47 µM 0.12130888425671 0.450454011827242 no 1866 0.451723191685035 2157 918317
SGTC_2212 7123476 200 µM 0.121287546564505 0.450445582478185 no 1867 0.451731641799051 2139 1085715
SGTC_2736 butenafine 14.65 µM 0.120384376954914 0.450088810365823 no 1868 0.452089333388548 2164 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_604 1000-0114 314 µM 0.11972225635307 0.449827283587257 no 1869 0.452351584573777 2199 1572745
SGTC_818 4072-2707 53.5 µM 0.119153379684717 0.449602604031673 no 1870 0.452576920527526 2173 882871
SGTC_849 0386-0493 241 µM 0.117998516866564 0.449146537243837 no 1871 0.453034416521342 2088 726119
SGTC_2355 9061122 103.12 µM 0.11798433161092 0.449140935762027 no 1872 0.45304003636345 2186 5302957
SGTC_914 3820-6779 408 µM 0.117220770411775 0.448839435268038 no 1873 0.45334255398848 2155 2893481
SGTC_991 3996-0057 64.7 µM 0.114820359127869 0.447891799823173 no 1874 0.454293755766076 2132 715343
SGTC_1144 3486-0183 12.5 µM 0.114700432237777 0.447844462785066 no 1875 0.454341285657197 2113 6744069
SGTC_1351 1496-0003 46.5 µM 0.11405037348677 0.447587887268375 no 1876 0.454598930827135 2194 3891978
SGTC_1701 st028638 40.4 µM 0.113407812131154 0.447334292494045 no 1877 0.454853623242762 2191 3490878
SGTC_775 4577-0580 57.3 µM 0.112720435295056 0.447063034573286 no 1878 0.455126099740983 2155 2006902
SGTC_2434 5670830 169.91 µM 0.112653071111618 0.447036452132645 no 1879 0.455152804072681 2115 1549830
SGTC_2972 9093619 59.92 µM 0.112262717051028 0.446882420014805 no 1880 0.45530755118429 1994 25236256
SGTC_1401 3807-4679 7.6 µM 0.111933941263082 0.446752692647297 no 1881 0.455437892233085 2182 3291456
SGTC_2874 9043904 71.43 µM 0.1114652495532 0.446567767527944 no 1882 0.455623710339967 2074 4463428
SGTC_1992 st073643 23.3 µM 0.11138863471837 0.446537539790145 no 1883 0.455654086078312 2212 3161292
SGTC_994 3910-0338 138 µM 0.111260623546531 0.446487034753684 no 1884 0.45570483967163 2173 3479481
SGTC_869 0564-0080 44.1 µM 0.110963978151556 0.446370000755861 no 1885 0.455822455775132 2032 6843321
SGTC_1638 st008370 60.6 µM 0.110205230399742 0.446070677146084 no 1886 0.456123307142029 2214 24207134
SGTC_2707 st078556 66.6 µM 0.109927780782737 0.445961231805963 no 1887 0.456233325088493 2231 17250899
SGTC_3298 9116858 71.43 µM 0.109923148686611 0.445959404621435 no 1888 0.45623516189626 2169 2506942
SGTC_957 1187-1561 14.1 µM 0.109629305698285 0.445843497162952 no 1889 0.456351684074329 2218 1538454
SGTC_1723 st034307 2.5525 µM 0.108991247476963 0.445591828675817 no 1890 0.456604716239807 2124 867466
SGTC_3099 9120367 49.47 µM 0.108366959942816 0.445345612959952 no 1891 0.456852304451922 2218 24824940
SGTC_1366 1683-0113 21.9 µM 0.108081860198036 0.445233178127867 no 1892 0.456965378658969 2172 708623
SGTC_1060 3448-7350 82 µM 0.108033423960691 0.445214076758714 no 1893 0.456984589437027 2210 570178
SGTC_1559 coumarin 343 70.1 µM 0.107681064712685 0.445075123799577 no 1894 0.457124345167334 2178 108770 A hepatotoxic, DNA x-linker.
SGTC_143 4032-1194 15.74 µM 0.107483582949755 0.444997249765872 no 1895 0.457202674388432 2109 1806963
SGTC_1818 st052136 56.3 µM 0.10729857896706 0.444924298087236 no 1896 0.457276055927758 2135 674169
SGTC_93 0109-0045 59.227 µM 0.105442724618797 0.444192592105004 no 1897 0.458012257827378 2236 88733
SGTC_2324 6149169 200 µM 0.105220608440817 0.444105031257931 no 1898 0.458100379160825 2193 2888231
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.104119572866168 0.443671030262682 no 1899 0.458537229188596 2226 1273210
SGTC_746 1095-0025 46.6 µM 0.10388258638306 0.443577624868716 no 1900 0.458631263192302 2206 6749286
SGTC_1500 4488-1866 171 µM 0.10202545609401 0.44284576806459 no 1901 0.459368234735151 2218 2900003
SGTC_3150 9097574 49.47 µM 0.101670985946789 0.442706100760875 no 1902 0.459508916318574 2211 17217476
SGTC_1166 k206-0078 225 µM 0.101037246875477 0.442456414476795 no 1903 0.459760446360161 2204 5404595
SGTC_2161 5662504 8.5105 µM 0.10054070462239 0.44226079820739 no 1904 0.459957534458716 2125 2859334
SGTC_2744 captopril 92.04 µM 0.100537692177522 0.442259611476726 no 1905 0.459958730191731 2233 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2029 5175081 200 µM 0.100402528224004 0.442206365157355 no 1906 0.460012381339184 2223 1380876
SGTC_1398 3558-0053 112 µM 0.0975446138163747 0.441080767842921 no 1907 0.461146953213629 2150 4532369
SGTC_1525 8-methoxypsoralen 92.5 µM 0.0974535360307866 0.441044904385719 no 1908 0.461183115702398 2249 4114 Related to psoralen; DNA damaging agent.
SGTC_1675 st018485 24.5 µM 0.0970716181576223 0.440894522869021 no 1909 0.4613347599119 2103 3323024
SGTC_1974 st069448 26.9 µM 0.0967023093995594 0.440749114341051 no 1910 0.461481402896442 2240 6323587 YNR016C ACC1
SGTC_2384 9036245 200 µM 0.095512270656501 0.440280612925418 no 1911 0.461953972122086 2186 6462766
SGTC_1002 4049-0206 172 µM 0.0942100630096876 0.439768048006666 no 1912 0.462471145601993 2189 4662749
SGTC_1677 st019204 53.9 µM 0.0938456527785443 0.43962462970501 no 1913 0.462615883004587 2055 3945625
SGTC_1880 MG-132 525 µM 0.0936235346474848 0.439537216162452 no 1914 0.462704106890348 2236 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_673 1082-0474 110 µM 0.093603503592986 0.439529333180305 no 1915 0.462712063185955 2202 3098046
SGTC_2878 9043973 25.97 µM 0.0936010465432942 0.439528366239409 no 1916 0.462713039122306 2217 6465167
SGTC_1296 1068-0102 11.9 µM 0.0912276358907916 0.438594509772855 no 1917 0.463655858121147 2216 767053
SGTC_3214 9129694 49.47 µM 0.0903970587255768 0.438267786334131 no 1918 0.463985846961237 2226 17158655
SGTC_255 tunicamycin 200.472 nM 0.0899853588758385 0.438105851893153 no 1919 0.464149424774058 2243 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_714 4296-0578 26.1 µM 0.0893277321960972 0.437847208239284 no 1920 0.464410727528858 2230 1589775
SGTC_1437 4092-1038 11.6 µM 0.0848591653515729 0.43609043586469 no 1921 0.466186677984304 2234 3977136
SGTC_2244 6635614 200 µM 0.0844027750324035 0.435911080914668 no 1922 0.466368100502234 2100 836499
SGTC_1829 berberine 14.4 µM 0.0830717397566375 0.435388078248386 no 1923 0.466897248282489 2260 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3226 9131256 49.47 µM 0.0820076874892219 0.434970062238696 no 1924 0.467320300158557 2259 17178073
SGTC_3336 9143619 71.43 µM 0.0811755865296651 0.434643219583269 no 1925 0.467651157278243 2269 45595730
SGTC_3090 9117696 49.47 µM 0.0802433845870393 0.434277111109175 no 1926 0.468021842738928 2242 7923821
SGTC_1051 3253-3903 78 µM 0.0798201764052149 0.434110920961529 no 1927 0.468190138536332 2259 5509239
SGTC_2882 9058044 58.44 µM 0.0791164271603144 0.433834590591409 no 1928 0.468470008742776 2150 18076804
SGTC_3087 9117406 49.47 µM 0.0757992796451569 0.4325325349916 no 1929 0.469789394618904 2152 42546093
SGTC_33 0986-0033 35.816 µM 0.0757235566162512 0.432502820481767 no 1930 0.46981951716398 2275 2848082
SGTC_795 0685-0265 78 µM 0.0748761551568886 0.43217031734875 no 1931 0.470156624358112 2305 302754
SGTC_1718 roemerine 11.9335 µM 0.0740076865592905 0.431829597743463 no 1932 0.47050213452305 2270 235224 An aporphine alkaloid with mutagenic activity.
SGTC_798 1287-0182 476 µM 0.0732453530633718 0.431530559085488 no 1933 0.470805438379363 2270 1649755
SGTC_827 3253-0474 693 µM 0.0730614480474652 0.431458424991809 no 1934 0.470878609817967 2268 5402065
SGTC_2097 5376186 200 µM 0.071422344938495 0.430815611653391 no 1935 0.471530813165538 2266 742755
SGTC_1700 st030840 7.9285 µM 0.071088992254942 0.43068490182472 no 1936 0.47166346445699 2287 5499307
SGTC_2299 7976368 114.88 µM 0.0707320604777215 0.430544954893059 no 1937 0.471805502080021 2259 2979718
SGTC_592 k241-0073 46.5 µM 0.0700472797575068 0.430276488353295 no 1938 0.472078014111423 2281 4230158
SGTC_3096 9117468 49.47 µM 0.0690588266059566 0.429889024673397 no 1939 0.472471397177781 2277 41316311
SGTC_643 k048-0106 28.4 µM 0.0689591429623305 0.429849953430571 no 1940 0.472511070618092 2244 6763920
SGTC_3322 9139058 2.11 µM 0.0686285798846775 0.429720393359204 no 1941 0.472642634517531 2232 4908926 YPR165W RHO1
SGTC_3294 9122953 26.2835 µM 0.0684859958427441 0.429664511659565 no 1942 0.472699383799793 2285 16459826
SGTC_3334 9142812 21.919 µM 0.0668304269856666 0.429015762691584 no 1943 0.473358350159272 2252 45283678
SGTC_2330 7979373 200 µM 0.0656608772787461 0.42855757997447 no 1944 0.473823910286183 2237 1863007
SGTC_1624 st003710 6.25 µM 0.0648448470756138 0.428237949019386 no 1945 0.474148766881274 2277 24207033
SGTC_2151 5563267 85.4165 µM 0.0642978695131628 0.428023729659628 no 1946 0.474366524914391 2196 5310824
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0641185093818744 0.427953489322939 no 1947 0.474437931907765 2278 94937 An inhibitor of serotonin biosynthesis.
SGTC_2271 7849410 118.62 µM 0.0632299873103924 0.427605563376843 no 1948 0.474791683064069 2321 972430
SGTC_373 0844-0104 25.9 µM 0.0625873775365988 0.427353966407106 no 1949 0.475047540488834 2307 5375804
SGTC_1064 honokiol 6.76 µM 0.0596697213908042 0.426212007874942 no 1950 0.476209343789773 2208 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3249 9135183 49.47 µM 0.0596273462181244 0.426195426940931 no 1951 0.476226218990534 2259 4902779
SGTC_3148 9097893 49.47 µM 0.0592053600328469 0.426030315560897 no 1952 0.476394270222499 2246 17174100
SGTC_2385 9074692 200 µM 0.0591574658483354 0.426011576726188 no 1953 0.476413343806382 2166 17046906
SGTC_2796 7949634 45.45 µM 0.0584565195367034 0.425737347178573 no 1954 0.476692497809222 2271 2971588
SGTC_3191 9110352 49.47 µM 0.058288428990261 0.425671590850433 no 1955 0.476759442086698 2308 17122424
SGTC_1978 st071761 42 µM 0.0563769767923247 0.42492398447528 no 1956 0.477520748818555 2151 5147680
SGTC_3084 9116877 49.47 µM 0.0560528834846155 0.424797251929045 no 1957 0.477649839209546 2323 27241325
SGTC_3010 9080089 71.4286 µM 0.0550928329672312 0.424421882107111 no 1958 0.47803225296908 2305 17027233
SGTC_551 k048-0028 34.9 µM 0.0541482809561086 0.424052638925584 no 1959 0.478408513001482 2297 6836383
SGTC_1248 0469-0687 58.6 µM 0.053861031299041 0.423940360825011 no 1960 0.478522942046279 2262 4017482
SGTC_1038 k292-0204 154 µM 0.0525861871399514 0.423442133441682 no 1961 0.479030811404139 2311 4454212
SGTC_1386 3228-0095 33.8 µM 0.0514844345745952 0.423011651290714 no 1962 0.47946975240591 2291 870181
SGTC_1623 st003709 20.3 µM 0.0502106333447795 0.422514060028563 no 1963 0.479977269029852 2306 16192618
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0491528655490869 0.422100952890806 no 1964 0.480398736836192 2317 1273210
SGTC_1257 0669-0121 16 µM 0.0473402050683947 0.421393224806763 no 1965 0.481121042488174 2282 4307855
SGTC_2875 9039966 71.43 µM 0.045961362998004 0.420855044969493 no 1966 0.481670522603548 2284 6463691
SGTC_1889 st059080 5.18 µM 0.0450547682624122 0.420501269870001 no 1967 0.482031827240566 2321 176925 Isolated from Daphnopsis sellowiana.
SGTC_2688 kanamycin b 96.69 µM 0.0448277810723533 0.420412704040815 no 1968 0.482122290626181 2278 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2649 anisomycin 9.56 µM 0.0445010842867971 0.420285240609743 no 1969 0.482252493849483 2283 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1021 4476-0760 85.3 µM 0.0443143220489264 0.420212377544928 no 1970 0.482326927772758 2302 746768
SGTC_528 3492-0019 172 µM 0.0435294457185146 0.419906197303329 no 1971 0.482639746238218 2328 2869262
SGTC_706 4262-0057 46.9 µM 0.0432135841292601 0.419782993371594 no 1972 0.482765638317644 2329 883298
SGTC_2350 9023895 38.85 µM 0.0423125483627966 0.419431581567903 no 1973 0.483124771049344 2284 2997209
SGTC_1220 1838-0075 193 µM 0.0414756727926479 0.419105250343115 no 1974 0.483458343230485 2278 5529645
SGTC_867 0518-0118 155 µM 0.040671059837085 0.418791552064374 no 1975 0.48377906670136 2331 6848158
SGTC_2111 5486399 200 µM 0.0405073863054358 0.418727746199369 no 1976 0.48384430922806 2322 689674
SGTC_161 4065-0411 162.148 µM 0.0340432304083371 0.41620951067347 no 1977 0.486421338891708 2309 1906281 YLR208W SEC13
SGTC_2518 prenyletin 46.28 µM 0.0339122229320215 0.416158509382299 no 1978 0.486473573152458 2343 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_201 4262-0159 12.803 µM 0.0326255198829498 0.415657670247811 no 1979 0.486986609368298 2344 1341029
SGTC_2363 9053361 176 µM 0.0315678783626842 0.415246094059465 no 1980 0.48740832998475 2346 6469797 YMR079W SEC14
SGTC_2251 lansoprazole 556 µM 0.0313652062984761 0.415167235788239 no 1981 0.487489144421239 2287 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_379 3970-0972 5.9 µM 0.0301568089760774 0.414697127947691 no 1982 0.487970997147363 2314 2898042 YBL034C STU1
SGTC_536 3852-0578 10.6 µM 0.0292644017925748 0.414350029437299 no 1983 0.48832685899453 2352 2869208
SGTC_1776 st049249 45.9 µM 0.0281403655124902 0.413912934835472 no 1984 0.488775099893302 2335 1822314
SGTC_2198 6589944 200 µM 0.0279123455665841 0.413824279614647 no 1985 0.488866030971171 2307 5290268
SGTC_1097 itavastatin 7.23 µM 0.0277980962306768 0.413779860590149 no 1986 0.488911592182543 2350 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_546 peri-Naphthalide 147 µM 0.0273190051764963 0.413593606692288 no 1987 0.489102649293187 2326 223824 A penicillin ester.
SGTC_492 tmb-8 126 µM 0.0272886687619386 0.413581813606016 no 1988 0.489114747261234 2356 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1403 3909-7815 62.9 µM 0.0262139473807254 0.41316407294758 no 1989 0.489543345652326 2336 6615483
SGTC_1192 1488-0095 21.4 µM 0.0250594387504142 0.41271542876965 no 1990 0.490003776600793 2316 915875
SGTC_1332 1480-0653 17.5 µM 0.0228775543880447 0.411867856243852 no 1991 0.490873972356555 2368 5749438
SGTC_3 0833-0587 95.581 µM 0.0227120596909205 0.411803585066389 no 1992 0.490939978037734 2293 5382644
SGTC_3340 9146634 11.102 µM 0.0225880553234603 0.411755428537871 no 1993 0.490989435934638 2330 4907387
SGTC_2755 lomerizine 42.69 µM 0.0222434104569334 0.411621594263894 no 1994 0.491126894804459 2354 3949 A calcium channel blocker.
SGTC_499 genistein 192 µM 0.0216225926752573 0.41138054104883 no 1995 0.491374505697435 2370 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2302 7771753 200 µM 0.0212905968280137 0.411251646306583 no 1996 0.491506922392341 2332 2203047
SGTC_1260 0700-1617 7.75 µM 0.0208473123693511 0.411079559584272 no 1997 0.491683728057251 2332 2853078
SGTC_2808 7946468 45.46 µM 0.0200036257775179 0.41075208071438 no 1998 0.492020240096465 2356 2970879
SGTC_3143 9086658 49.47 µM 0.0191046061289797 0.410403192650211 no 1999 0.492378828471008 2338 25236626
SGTC_2400 5203494 178.7 µM 0.0179194079124869 0.409943353892482 no 2000 0.492851573112147 2383 6777674
SGTC_2581 avocatin a 64 µM 0.0176103885926459 0.409823479454518 no 2001 0.492974834532132 2354 6710728 A skin care supplement.
SGTC_1980 st071811 45.7 µM 0.0163285196906465 0.409326308381814 no 2002 0.49348615257459 2347 4974850
SGTC_1572 epiandrosterone 68.9 µM 0.0153606232944341 0.408951007672951 no 2003 0.493872238888406 2353 441302 A steroid.
SGTC_2608 thymoquinone 42.66 µM 0.015330167619126 0.408939199872622 no 2004 0.493884387514493 2383 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_655 k060-0012 42 µM 0.0144586210340575 0.408601332458328 no 2005 0.494232045720709 2375 5994525
SGTC_1906 st060206 94.7 µM 0.0141462411055212 0.408480250462943 no 2006 0.494356654535632 2366 5133468
SGTC_3043 9092303 49.47 µM 0.0139872954425459 0.408418644678004 no 2007 0.494420058407514 2379 25236084
SGTC_1563 conessine 56.1 µM 0.013847428500764 0.408364435490871 no 2008 0.494475851840517 2377 441082 An anti-amoebic, histamine inhibitor.
SGTC_936 3005-4620 401 µM 0.0138039318502618 0.408347577553984 no 2009 0.494493202835061 2386 777207
SGTC_1784 st039334 36.3 µM 0.0125362369817961 0.407856333434051 no 2010 0.494998896024454 2380 3496984
SGTC_906 1165-0455 526 µM 0.0122273296789479 0.407736650758333 no 2011 0.495122122761576 2389 3252859
SGTC_1568 digitonin 820 nM 0.0109664280007784 0.407248217932588 no 2012 0.495625115894802 2385 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_619 1652-1634 108 µM 0.0105130422403251 0.407072626050465 no 2013 0.495805980211511 2375 5400454
SGTC_902 1120-0002 2.07 µM 0.0101967846438804 0.406950153623496 no 2014 0.495932141973725 2382 3280475
SGTC_1241 0364-0022 50.8 µM 0.00870305167237775 0.406371820794773 no 2015 0.496528028549077 2380 4563895
SGTC_450 aminopyrene 156 nM 0.00703106819498832 0.40572471645559 no 2016 0.497195032731675 2384 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2662 daunorubicin 22.37 µM 0.00602216488008788 0.405334367144541 no 2017 0.497597518331381 2359 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_52 0329-0193 875 nM 0.00594780586502254 0.405305601021544 no 2018 0.497627182755118 2385 3739292
SGTC_1724 st037281 8.293 µM 0.00594556868682976 0.405304735566916 no 2019 0.497628075244307 2387 574124 YDL195W SEC31
SGTC_1139 k015-0024 46.9 µM 0.00558026952830675 0.405163425434467 no 2020 0.497773806102855 2387 2766652
SGTC_1020 4335-0961 93.3 µM 0.00357669744930447 0.404388595974788 no 2021 0.498573107205586 2393 669075
SGTC_2453 5731132 22.18 µM 0.00347974935808513 0.404351113302554 no 2022 0.498611783657433 2397 1362040
SGTC_1177 0983-0204 23.6 µM 0.0027578536594925 0.404072037140926 no 2023 0.49889977696674 2401 766818
SGTC_859 0439-0102 54.6 µM 0.00198344666127044 0.403772715018396 no 2024 0.499208719784722 2402 610143
SGTC_136 0097-0015 404.482 µM 0.000464156745856212 0.403185646212759 no 2025 0.499814828255993 2402 4861337
SGTC_1450 4112-4260 37.6 µM -0.00303049331632452 0.401836108505016 no 2026 0.498791009936183 2411 1633175
SGTC_1115 galangin 695.678 nM -0.00328282345264795 0.401738710634631 no 2027 0.498690345277989 2411 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2441 5730946 39.09 µM -0.00473969766326891 0.401176485731244 no 2028 0.498109141285411 2413 1774275
SGTC_3240 9133527 49.47 µM -0.0051318869511275 0.401025170169072 no 2029 0.497952682303409 2419 17617455
SGTC_2427 5545055 42.75 µM -0.00574139588209563 0.400790037210239 no 2030 0.497709527017832 2415 5372858
SGTC_1492 4158-0558 28.5 µM -0.00672661546466012 0.400410040721358 no 2031 0.497316488924124 2420 3967268
SGTC_774 k060-0086 136 µM -0.00779803271351608 0.399996905013907 no 2032 0.496889066575612 2424 5911235
SGTC_913 3487-1245 167 µM -0.00914996231460815 0.399475764206445 no 2033 0.496349744103033 2427 4016153
SGTC_364 0083-0097 67.7 µM -0.00982259486022433 0.399216544965492 no 2034 0.496081414620158 2434 5207356
SGTC_1513 0337-0559 19 µM -0.0106175825398015 0.398910229781487 no 2035 0.495764276993706 2435 775073
SGTC_2374 9071832 200 µM -0.0111945863399461 0.398687944523992 no 2036 0.495534099474441 2426 17381698
SGTC_1489 4065-0444 182 µM -0.0114855439850195 0.398575868300894 no 2037 0.495418031631657 2426 2877968
SGTC_1634 st006576 41 µM -0.0117605169693978 0.398469957020118 no 2038 0.495308340692156 2436 3915356
SGTC_1182 1222-0449 220 µM -0.0131419758032225 0.397937974147866 no 2039 0.49475726111809 2439 658318
SGTC_3034 9090421 49.47 µM -0.0137534929891539 0.39770254688346 no 2040 0.494513323119292 2416 17173761
SGTC_1684 st024538 14.6195 µM -0.014405128603889 0.397451715472064 no 2041 0.49425338389052 2435 6732859
SGTC_257 daunorubicin 18.5 µM -0.0147709380589433 0.397310924520846 no 2042 0.494107462560779 2472 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1157 4092-0394 27.6 µM -0.0163180489486694 0.396715628208809 no 2043 0.493490329239799 2449 3659885
SGTC_966 1300-0360 30.2 µM -0.0170984375656545 0.396415442004912 no 2044 0.493179042686486 2446 70588
SGTC_112 phenothiazine 287.218 µM -0.0194037400755337 0.395529037864096 no 2045 0.492259513411148 2440 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2220 6782180 200 µM -0.0206271008402257 0.395058866597485 no 2046 0.491771560859197 2441 833803
SGTC_3345 9148410 3.559 µM -0.0213249489853094 0.3947907326952 no 2047 0.491493220975093 2446 4903596
SGTC_2759 disulfiram 3.38 µM -0.0224887592047724 0.394343673274673 no 2048 0.491029039294515 2464 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_552 k242-0005 476 µM -0.0225053720592446 0.394337292713404 no 2049 0.491022413401422 2472 4088318
SGTC_1789 tunicamycin 25 nM -0.022765347535254 0.394237446652694 no 2050 0.4909187247588 2493 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1203 3992-3522 103 µM -0.0236520824753727 0.39389693995779 no 2051 0.490565063972799 2448 5322312
SGTC_2469 5655019 90.81 µM -0.0237421175805093 0.393862370959938 no 2052 0.490529155246386 2456 2788239
SGTC_2059 5238311 157 µM -0.0247451396307461 0.393477317044636 no 2053 0.490129124936024 2455 703021
SGTC_1921 5740136 50 µM -0.0261505929476078 0.392937947571786 no 2054 0.489568611752761 2456 1774243
SGTC_2032 5185112 25.99 µM -0.0262320796714396 0.392906681782452 no 2055 0.489536114401619 2457 5718189
SGTC_2701 st077767 14.721 µM -0.0264458453916145 0.39282466490845 no 2056 0.489450863793951 2473 5721188
SGTC_1967 st070177 51.4 µM -0.0268012329579572 0.392688321599068 no 2057 0.489309134907083 2473 5729214
SGTC_123 0083-0120 66.675 µM -0.0272238160106557 0.392526216093507 no 2058 0.489140610157124 2464 16001701
SGTC_375 3970-0961 9.27 µM -0.0272962331967333 0.392498438277904 no 2059 0.489111730612094 2467 2898222
SGTC_3069 9117009 49.47 µM -0.0295341278002086 0.391640296317206 no 2060 0.48821930037869 2456 41904981
SGTC_218 alverine citrate 93.75 µM -0.0297312953856997 0.391564715733226 no 2061 0.488140676419973 2504 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3127 9126946 49.47 µM -0.0304153460009995 0.391302529205316 no 2062 0.487867903089535 2503 27243249
SGTC_1766 st045414 44.774 µM -0.0307780720026194 0.391163521697586 no 2063 0.487723264070459 2462 253960
SGTC_920 mycophenolic acid 780.421 nM -0.0313082375447556 0.390960371337443 no 2064 0.487511860509531 2476 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_297 0986-0032 24 µM -0.0318887242734392 0.390737972882089 no 2065 0.487280395397135 2452 2847425
SGTC_501 nsc-95397 161 µM -0.0328517245260325 0.390369103125456 no 2066 0.486896415121176 2477 262093
SGTC_697 0508-1955 564 µM -0.0333100997750848 0.390193560689517 no 2067 0.486713649887273 2463 6243113
SGTC_2297 7971671 152.32 µM -0.0336661323990208 0.390057227512019 no 2068 0.486571693042483 2496 909016
SGTC_2888 9058547 12.99 µM -0.0339821747376994 0.389936218874027 no 2069 0.486445682494988 2481 16476514
SGTC_1321 1326-2144 215 µM -0.0348620558962639 0.389599379659517 no 2070 0.486094868608529 2464 3513030
SGTC_204 PMA1.184 62.41 µM -0.0356067914104946 0.389314342156362 no 2071 0.485797946497405 2452 2252213 YGL008C PMA1
SGTC_2963 9082507 9 µM -0.0357964966827073 0.389241744524225 no 2072 0.485722313260322 2535 16459611
SGTC_1648 st011736 69.8 µM -0.0362409848697339 0.389071660074714 no 2073 0.485545103119887 2485 2855514
SGTC_959 1222-0044 107 µM -0.038579419574345 0.388177203304791 no 2074 0.484612855437961 2479 6083612
SGTC_2289 7946404 165.07 µM -0.0394995956090573 0.387825396077365 no 2075 0.484246037961935 2483 1246120 YPR165W RHO1
SGTC_2438 5259590 200 µM -0.0398781649095667 0.387680685900583 no 2076 0.484095129565616 2526 1201127
SGTC_2657 nystatin 74.44 µM -0.0418708163570896 0.386919241643604 no 2077 0.483300840580442 2512 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2829 7992743 58.44 µM -0.0426714586693207 0.386613417611247 no 2078 0.482981715760476 2475 16462845
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0432609391982137 0.386388296743781 no 2079 0.482746764029068 2482 688803
SGTC_2575 plumbagin 510 nM -0.0436716100668898 0.386231485348834 no 2080 0.482583084751451 2472 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_357 1325-0123 420 µM -0.0440670451796562 0.386080509165648 no 2081 0.482425480695742 2475 1098503
SGTC_2916 7875993 68.79 µM -0.0450919823607903 0.385689270944817 no 2082 0.482016996036556 2489 1299250
SGTC_3133 9127736 49.47 µM -0.0466694200638927 0.385087359946108 no 2083 0.481388351516061 2473 27243420
SGTC_3231 9132313 49.47 µM -0.0478695164103663 0.384629618318172 no 2084 0.480910116954408 2522 4905967
SGTC_334 1502-1024 68.5 µM -0.0485072554706187 0.384386436803038 no 2085 0.480655991110487 2584 3296216
SGTC_1155 4088-0394 48.2 µM -0.0489204505508958 0.384228902276919 no 2086 0.480491345595176 2487 2326248
SGTC_783 0848-0141 92.7 µM -0.0498087780338745 0.383890283814413 no 2087 0.480137385754044 2497 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2041 5107442 45.335 µM -0.0499161164146963 0.383849373867114 no 2088 0.480094617135736 2499 793005
SGTC_3057 9095946 49.47 µM -0.0500299295862721 0.383805997592473 no 2089 0.480049268909051 2478 24540043
SGTC_2628 lathosterol 100 µM -0.0502510411345598 0.38372173211217 no 2090 0.479961168978188 2559 6710616
SGTC_1042 0350-0096 82 µM -0.0508022475190258 0.383511691631209 no 2091 0.479741549965249 2476 3122515
SGTC_2418 pentamidine 31.67 µM -0.0521279797612268 0.38300665372217 no 2092 0.479213359321526 2476 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1279 0874-0590 65.2 µM -0.0524289793873259 0.382892015530194 no 2093 0.47909344182638 2557 3523074
SGTC_2534 helenine 20.12 µM -0.0526665245251543 0.382801551745161 no 2094 0.478998805775521 2507 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1614 st002383 48.6 µM -0.0526757825983352 0.38279802614321 no 2095 0.478995117458402 2494 1947235
SGTC_1300 1094-0077 113 µM -0.0532476752056649 0.382580260389985 no 2096 0.478767285073383 2505 5532636
SGTC_1311 1190-0148 100 µM -0.053331517366209 0.382548338019263 no 2097 0.478733884349728 2544 1961333
SGTC_1983 st071813 46.9 µM -0.0541631850527875 0.382231729076759 no 2098 0.478402575839935 2560 11838595
SGTC_394 menadione 8.33 µM -0.0560398950143647 0.381517570825717 no 2099 0.47765501272758 2490 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1473 k844-0725 134 µM -0.0577450155355594 0.380869058243075 no 2100 0.476975868141621 2493 54682906
SGTC_2708 st078559 56 µM -0.0580678451445779 0.380746313291024 no 2101 0.476847293507899 2509 17250902
SGTC_2304 7443016 91.4 µM -0.0608289843992905 0.379696975727764 no 2102 0.475747703421908 2504 939854
SGTC_56 0957-0365 83.25 µM -0.0608972049802694 0.37967106049734 no 2103 0.475720537709587 2506 6752360
SGTC_2917 7979103 53.79 µM -0.061231087891093 0.379544234831496 no 2104 0.475587585809106 2567 2980565
SGTC_1488 4013-0813 75.9 µM -0.0632593331872259 0.378774083313359 no 2105 0.474779999143608 2509 2910057
SGTC_1514 1189-1591 158 µM -0.0648652176486209 0.378164648870734 no 2106 0.474140657271592 2589 767698 YMR146C TIF34
SGTC_2360 9040895 200 µM -0.065281967823977 0.378006541305128 no 2107 0.473974749653528 2550 4914414
SGTC_1973 st070275 50.2 µM -0.0655165801975613 0.37791754255162 no 2108 0.473881352804332 2490 17118334
SGTC_2585 alliin 100 µM -0.0662735769332287 0.377630424721791 no 2109 0.473580009758314 2578 87310 A garlic compound which reacts with lipids.
SGTC_3229 9132204 49.47 µM -0.0662754340530788 0.377629720426362 no 2110 0.473579270499996 2524 17682924
SGTC_1118 chelidonine 707.474 nM -0.0671476682940355 0.377298978712309 no 2111 0.47323207284369 2538 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0676031322821656 0.377126307478951 no 2112 0.473050780952761 2552 279621
SGTC_2565 isoliquiritigenin 100 µM -0.0680411916844816 0.37696025768472 no 2113 0.472876422010854 2642 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1946 st076057 65.1 µM -0.0682330407831275 0.37688754296742 no 2114 0.472800062755241 2532 953009
SGTC_992 3909-8734 162 µM -0.0694604446984747 0.376422435310111 no 2115 0.47231155856597 2560 4288319
SGTC_1730 st033808 45.1 µM -0.0697872304865904 0.376298634584006 no 2116 0.472181505496089 2551 1045166
SGTC_2614 arthonioic acid 13.39 µM -0.0705438560159093 0.376012040656468 no 2117 0.471880397709653 2520 6710684
SGTC_335 4077-0256 27.6 µM -0.0715930737472191 0.375614732089223 no 2118 0.471462876140543 2631 3121989
SGTC_1798 st045719 60.953 µM -0.0736921789274206 0.374820257531528 no 2119 0.470627661090355 2526 3980186
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0740023074693765 0.374702924246222 no 2120 0.470504274601091 2620 688751
SGTC_2043 5101342 149 µM -0.074041352887943 0.374688152718505 no 2121 0.470488740349 2570 678451
SGTC_1487 3970-0795 2.82 µM -0.07460687793438 0.374474225866791 no 2122 0.470263750788841 2596 3765103
SGTC_1475 4092-1048 11.7 µM -0.0748877962230537 0.37436797443617 no 2123 0.470151993246887 2575 2881759
SGTC_266 formosanin C 406 nM -0.0754211080955584 0.374166286698816 no 2124 0.469939832603644 2551 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2341 7987486 176.74 µM -0.0755972877387712 0.374099666694275 no 2125 0.469869747181068 2557 1258686
SGTC_1026 k007-1105 30.6 µM -0.0765616984121961 0.373735054211322 no 2126 0.46948611485976 2530 7066794
SGTC_1705 st027868 56.3335 µM -0.076917401821541 0.373600602757728 no 2127 0.46934462695339 2623 292948
SGTC_2656 pseudo-anisatin 100 µM -0.0771579553404643 0.373509685245188 no 2128 0.469248944334695 2539 6708809 A neurotoxin.
SGTC_269 exalamide 29 µM -0.0794241876039688 0.372653506060538 no 2129 0.468347615241801 2575 3316 A derivative of salicylamide.
SGTC_2258 7960471 200 µM -0.0802206320101374 0.372352759656339 no 2130 0.468030890535801 2613 2974708
SGTC_1173 0443-0020 122 µM -0.0811822702055418 0.371989737940587 no 2131 0.467648499648704 2569 5331295
SGTC_2008 4012253 172 µM -0.081258778996843 0.37196086049099 no 2132 0.467618077566501 2574 603940
SGTC_2697 mebhydrolin 72.4 µM -0.0813532291822392 0.3719252122417 no 2133 0.467580521734086 2595 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1125 tnp00248 1.32998 µM -0.082675386996555 0.371426306780644 no 2134 0.467054828093981 2639 24207736
SGTC_3216 9129716 49.47 µM -0.0839460857231849 0.37094702245278 no 2135 0.466549648869035 2589 8056934
SGTC_300 r073-0011 5.04 µM -0.0848818467062431 0.370594198431668 no 2136 0.466177661962707 2555 2735780
SGTC_2361 9034121 116 µM -0.0874684460198173 0.369619500910046 no 2137 0.465149582853256 2604 6496917
SGTC_170 4197-0004 226 µM -0.0898303871580293 0.368730191455145 no 2138 0.464211000170818 2672 218692
SGTC_3026 9090633 49.47 µM -0.0898830803493487 0.368710359600578 no 2139 0.464190063324246 2559 25236842
SGTC_326 k292-0812 17.5 µM -0.0911401610370653 0.368237342641486 no 2140 0.463690610762556 2540 3579357
SGTC_2061 5245884 80.95 µM -0.0917672842156814 0.368001442018516 no 2141 0.463441468881577 2585 573863
SGTC_3022 9087993 49.47 µM -0.0934437439144498 0.367371064258722 no 2142 0.462775519951 2559 17173644
SGTC_1271 0832-2808 169 µM -0.0934496575817483 0.367368841249193 no 2143 0.462773171017285 2645 3663794
SGTC_3174 9107204 49.47 µM -0.0942995686208335 0.367049397041429 no 2144 0.462435596290136 2652 3938802
SGTC_438 sphingosine 6.67 µM -0.094375137151148 0.367020998603571 no 2145 0.462405582659611 2582 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_846 0335-0850 148 µM -0.0951155063302102 0.366742808487812 no 2146 0.462111540823008 2575 6819598
SGTC_225 nsc-122657 1.016 µM -0.0955091103908571 0.366594942158452 no 2147 0.461955227148236 2691 275685
SGTC_569 4130-2812 160 µM -0.0955356884865492 0.366584958204837 no 2148 0.461944672286217 2573 743552
SGTC_1236 0330-0013 258 µM -0.0967425169498398 0.366131713208741 no 2149 0.461465437260641 2614 4617066
SGTC_1361 1608-0041 5.61 µM -0.0981725345510346 0.365594887471759 no 2150 0.460897645672307 2595 X1361
SGTC_3113 9123498 49.47 µM -0.0985522636214924 0.365452382112492 no 2151 0.460746886767179 2566 8897275
SGTC_658 3253-0951 102 µM -0.1005740640323 0.364693950590049 no 2152 0.459944293096101 2630 1184878
SGTC_2476 5806916 10.51 µM -0.100674145484986 0.364656421078376 no 2153 0.459904567995595 2616 2870194
SGTC_2281 7943571 200 µM -0.10137988813564 0.364391811709439 no 2154 0.459624450576061 2637 1244024
SGTC_3195 9113082 49.47 µM -0.10281396874058 0.363854320307562 no 2155 0.459055309283836 2567 17018038
SGTC_1355 1499-0035 1.68 µM -0.103111196112098 0.363742953371521 no 2156 0.458937359588479 2602 1548538
SGTC_1444 4112-3581 28 µM -0.107207933590612 0.362209139593857 no 2157 0.457312010805903 2592 2877249
SGTC_2233 sulbentine 40.3845 µM -0.108856719788697 0.361592458165107 no 2158 0.4566580675901 2595 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2162 5663267 200 µM -0.110029787216847 0.361153924436174 no 2159 0.456192875774228 2603 6456493
SGTC_1749 st037932 54.2 µM -0.110033443730526 0.361152557788064 no 2160 0.456191425840087 2713 594497
SGTC_620 0109-0052 432 µM -0.110187445321607 0.361095000202571 no 2161 0.456130359412722 2621 493037
SGTC_294 k038-0071 157 µM -0.110780642234506 0.360873324215153 no 2162 0.455895148056891 2651 24152826
SGTC_2724 maprotiline 69.64 µM -0.112797906772687 0.360119828288406 no 2163 0.455095388953114 2606 4011 A tricyclic antidepressant.
SGTC_3296 9122258 64.045 µM -0.113463552571162 0.359871312899698 no 2164 0.454831528635674 2701 4730474
SGTC_1929 genistein trimethyl ether 50.5 µM -0.114605811844166 0.359444994423674 no 2165 0.454378786440744 2614 136420
SGTC_2850 9015429 58.44 µM -0.114819546125026 0.359365243087561 no 2166 0.45429407797632 2654 6457570
SGTC_744 1594-0068 283 µM -0.116806061613147 0.358624301883109 no 2167 0.453506870082256 2628 668392
SGTC_213 1246-0773 967 nM -0.118187485973861 0.358109364117593 no 2168 0.452959552603621 2647 6251622
SGTC_1971 st069429 63.5 µM -0.119480986197741 0.357627434692182 no 2169 0.452447151468696 2668 1246522 YGL099W LSG1
SGTC_2650 prasterone 100 µM -0.120677735461706 0.3571817545764 no 2170 0.451973147310238 2615 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_554 4483-2211 187 µM -0.121568828524059 0.356850030033611 no 2171 0.451620250787028 2719 747107
SGTC_219 mitoxanthrone 164.414 µM -0.122018299408332 0.356682747897524 no 2172 0.45144226286386 2699 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1704 st028805 70.8 µM -0.122401515458769 0.356540145964789 no 2173 0.451290519187062 2653 2876101
SGTC_2938 9059746 27.26 µM -0.122847040542919 0.356374382872448 no 2174 0.451114111688274 2718 6471769
SGTC_1920 st075728 45.7 µM -0.123034853944967 0.35630451271189 no 2175 0.451039749086232 2649 3400306
SGTC_2236 dapsone 200 µM -0.123046254574589 0.356300271615929 no 2176 0.45103523519058 2641 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_694 1315-0438 43.2 µM -0.123059096149979 0.356295494501624 no 2177 0.451030150783245 2675 6793154
SGTC_3009 9080819 71.4286 µM -0.123615910329032 0.356088379232535 no 2178 0.450809697245795 2691 17027216
SGTC_3239 9133757 49.47 µM -0.123822840643062 0.356011419259438 no 2179 0.450727773383078 2612 17036923
SGTC_1734 st037168 69.4 µM -0.123833582986248 0.356007424207739 no 2180 0.450723520538835 2736 708907
SGTC_236 1509-0011 5.31 µM -0.124077756053435 0.355916621093479 no 2181 0.450626855071635 2691 3107280
SGTC_1887 st057648 70.8 µM -0.124478126125931 0.355767749104576 no 2182 0.450468359245802 2792 688672
SGTC_857 0438-0306 1.35 µM -0.124778211700732 0.355656180917153 no 2183 0.450349568553507 2702 4686136
SGTC_1771 st048882 4.1505 µM -0.12530012414722 0.355462169639445 no 2184 0.450142976951841 2637 4580403
SGTC_3040 9091894 49.47 µM -0.125918042655521 0.355232518303744 no 2185 0.44989840018966 2660 25236966
SGTC_1337 1486-1011 40.3 µM -0.126818655975832 0.354897896721234 no 2186 0.449541964812947 2637 X1337
SGTC_2802 7925815 54.55 µM -0.127048657401214 0.354812457950807 no 2187 0.449450943754228 2646 1262923
SGTC_2143 5623677 140.463 µM -0.127491024176184 0.354648152224506 no 2188 0.449275888441242 2611 5375313
SGTC_2978 9011784 42.97 µM -0.127783642160184 0.354539481679813 no 2189 0.449160097797136 2784 2994934
SGTC_1226 3909-7979 35.4 µM -0.128439382736799 0.354296000055545 no 2190 0.448900633160681 2753 6615510
SGTC_2054 5233173 129 µM -0.128456633972016 0.354289595339905 no 2191 0.448893807454749 2741 6889
SGTC_885 0865-0106 16.8 µM -0.128498577251591 0.354274023596225 no 2192 0.448877212039981 2631 2793380
SGTC_3050 9093513 49.47 µM -0.129125097215461 0.354041452574873 no 2193 0.448629331770423 2653 25236664
SGTC_1137 ixabepilone 100 µM -0.13089153333425 0.35338602566267 no 2194 0.447930556239694 2622 154225 A novel microtubule stabilizer.
SGTC_295 k015-0027 31 µM -0.131053297136151 0.353326025738028 no 2195 0.447866572957259 2726 3887424
SGTC_776 4476-4378 112 µM -0.131872674989358 0.353022165749114 no 2196 0.447542501020676 2734 2892008
SGTC_803 4488-1585 147 µM -0.132230819415734 0.352889380055036 no 2197 0.447400862389901 2743 747204
SGTC_1922 5578187 25 µM -0.134243196320768 0.352143604388882 no 2198 0.44660513464912 2868 1350412
SGTC_1376 2910-0861 41.3 µM -0.135017590947065 0.351856769316106 no 2199 0.446298983060305 2655 1112859
SGTC_1235 benzylparaben 21.5 µM -0.135314185016677 0.351746933455393 no 2200 0.446181735102528 2722 7180
SGTC_1811 st050069 61.5 µM -0.135426404463794 0.351705379142409 no 2201 0.446137374346228 2647 3877702
SGTC_1009 4106-0057 9.87 µM -0.135713795361499 0.35159896777664 no 2202 0.44602377075265 2636 2928005
SGTC_2814 7977482 42.97 µM -0.136330638783718 0.351370610282683 no 2203 0.44577995187415 2770 6456762
SGTC_3108 9121785 49.47 µM -0.137733988557349 0.350851285456917 no 2204 0.445225328204028 2587 17140271
SGTC_3060 1327-0027 12.5 µM -0.13824157940927 0.350663514486593 no 2205 0.445024747464729 2739 16000455 YPR107C YTH1
SGTC_246 cycloheximide 667 µM -0.139945635127626 0.350033407260872 no 2206 0.444351472213286 2639 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1941 st076221 61.8 µM -0.142181517631335 0.349207273067039 no 2207 0.4434683151303 2822 2828568
SGTC_1680 diphenhydramine 100 µM -0.142388306382331 0.349130902892846 no 2208 0.443386649215725 2732 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1143 3454-2408 5.08 µM -0.142749351148297 0.348997578315308 no 2209 0.443244069609758 2632 X1143
SGTC_488 nitrendipine 139 µM -0.143576588577321 0.348692171036671 no 2210 0.442917414347321 2653 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1199 1638-0010 4.46 µM -0.143716559538863 0.348640504934568 no 2211 0.442862147165213 2659 3111136
SGTC_1464 k208-0027 110 µM -0.144691889569941 0.348280568947907 no 2212 0.442477071477693 2810 X1464
SGTC_3017 9080681 49.47 µM -0.146051858212378 0.347778913931025 no 2213 0.441940225184063 2737 16451914
SGTC_1821 st053465 65.6 µM -0.146699110880099 0.347540253730264 no 2214 0.441684760213502 2754 675086
SGTC_508 roscovitine 141 µM -0.146976235559807 0.347438088559772 no 2215 0.441575388934375 2662 160355 A CDKinase inhibitor.
SGTC_777 1315-0167 517 µM -0.148338793912906 0.34693592721967 no 2216 0.441037700446375 2757 4221767
SGTC_1959 st077091 55.8 µM -0.149858594894474 0.346376132233093 no 2217 0.440438089612574 2647 821356 YKL052C ASK1
SGTC_898 1000-0849 28.3 µM -0.150162813801413 0.346264118193068 no 2218 0.440318081734865 2641 6751807
SGTC_2748 diazoxide 86.69 µM -0.151779173005511 0.345669197063487 no 2219 0.439680554667886 2763 3019 A potassium channel activatior.
SGTC_1317 1273-0028 910 nM -0.151995332191973 0.345589665829403 no 2220 0.439595308624197 2708 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1268 0828-0275 2.46 µM -0.152243992547268 0.345498184901917 no 2221 0.439497248657284 2780 745337
SGTC_2918 7977171 22.06 µM -0.152435824566052 0.345427617006621 no 2222 0.439421601653865 2639 2236483
SGTC_1653 st012112 65 µM -0.153239121572861 0.345132172163725 no 2223 0.43910485371533 2827 720429
SGTC_1956 st077085 54 µM -0.153556769469594 0.345015370376383 no 2224 0.438979612760028 2718 24208685
SGTC_2975 9084847 53.72 µM -0.154136431622828 0.344802261820541 no 2225 0.438751081614739 2786 27211724
SGTC_2597 laccaic acid a 100 µM -0.154233043714556 0.344766747875544 no 2226 0.438712994390416 2785 5491415 A textile dye.
SGTC_976 1348-1067 47.6 µM -0.157570912536882 0.343540611975857 no 2227 0.437397462811265 2690 5310671 YGL099W LSG1
SGTC_3185 9108267 49.47 µM -0.158563298504853 0.343176384528951 no 2228 0.437006473221851 2755 4910486
SGTC_320 4092-0846 5.34 µM -0.159640118137484 0.342781332823362 no 2229 0.43658228726608 2788 1359356
SGTC_2667 digitoxin 100 µM -0.160007318794844 0.342646657570016 no 2230 0.436437654468521 2756 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1187 1391-0724 117 µM -0.160343381547762 0.342523420043105 no 2231 0.436305293698857 2726 6997986
SGTC_926 2268-1401 59.4 µM -0.161144478793923 0.342229717402804 no 2232 0.43598980448913 2676 2931578
SGTC_409 arachidonic acid 100 µM -0.161397847443767 0.342136845858125 no 2233 0.43589003096964 2687 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1092 toremifene 6.32 µM -0.163148464017274 0.341495423591128 no 2234 0.435200771088062 2678 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2611 pyromycin 23.93 µM -0.16388031375427 0.341227410873839 no 2235 0.434912682456016 2739 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_217 ketoconazole 989 nM -0.164161704293995 0.341124383370468 no 2236 0.434801923802286 2775 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1943 st076331 65.2 µM -0.164862872355015 0.34086771130143 no 2237 0.434525958013782 2730 24208415
SGTC_2310 7668677 200 µM -0.166328440404801 0.340331458211477 no 2238 0.43394924278177 2871 2197143
SGTC_597 k018-0003 82.8 µM -0.166557953922904 0.340247508142228 no 2239 0.433858939687545 2817 6786234
SGTC_2737 bleomycin 30.5 nM -0.166611980551359 0.340227747759284 no 2240 0.433837683176818 2716 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_3152 9099253 49.47 µM -0.167561972026571 0.339880357583739 no 2241 0.433463945029062 2795 25236131
SGTC_168 3970-0862 530.542 µM -0.167826116136037 0.339783790257779 no 2242 0.433360038094227 2773 3135186
SGTC_453 enantio-paf c16 10 µM -0.168681500850999 0.339471145963044 no 2243 0.433023585220172 2799 13871343 A lipid and platelet activating factor
SGTC_2836 9010338 19.48 µM -0.169821490679366 0.339054649816573 no 2244 0.432575262648825 2727 2994051
SGTC_2937 9044753 11.33 µM -0.170784911602602 0.338702816526036 no 2245 0.432196446780617 2705 6465530 YGL099W LSG1
SGTC_3002 9075603 71.4286 µM -0.17087055826047 0.338671545886134 no 2246 0.432162773636398 2705 20105405
SGTC_2428 5615643 7.78 µM -0.171246532994668 0.338534286081378 no 2247 0.432014959907447 2821 2253075
SGTC_1630 st005209 31.3 µM -0.172011348505541 0.338255135576201 no 2248 0.431714303581257 2693 3367314
SGTC_2140 5586273 200 µM -0.172798570768703 0.337967899641692 no 2249 0.431404880253058 2697 854421
SGTC_491 tetrandrine 80.3 µM -0.174040526436864 0.337514935708467 no 2250 0.430916806365909 2809 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2881 9058953 51.95 µM -0.174761446276992 0.337252110967154 no 2251 0.430633541736736 2699 17122249
SGTC_3284 9108171 64.8615 µM -0.17488484264608 0.337207132480011 no 2252 0.430585060270406 2817 8687505
SGTC_2659 sanguinarine 24.21 µM -0.175137225692525 0.337115145062001 no 2253 0.430485904208464 2704 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2716 st080858 38.6235 µM -0.175391099004679 0.33702262430342 no 2254 0.430386167073722 2842 5296050
SGTC_1687 st020778 55.3625 µM -0.175998052556137 0.336801468106886 no 2255 0.430147736200975 2737 4259299
SGTC_173 1273-0061 2.693 µM -0.176009715725298 0.336797218939977 no 2256 0.430143154782207 2836 2847414 YPL266W DIM1
SGTC_1196 1588-0294 184 µM -0.177676131445141 0.336190318843388 no 2257 0.429488665658032 2771 6144269
SGTC_2430 5571206 200 µM -0.179851319335002 0.335398768656053 no 2258 0.428634646721789 2850 1731771
SGTC_1696 st025591 34.7925 µM -0.181061669845171 0.334958638401044 no 2259 0.428159585155445 2744 2787147
SGTC_642 0335-0876 158 µM -0.181957826760083 0.33463290702638 no 2260 0.427807911346806 2717 6812350
SGTC_581 0958-0271 211 µM -0.182560248434082 0.334414011222934 no 2261 0.427571538615509 2717 4591145
SGTC_1223 0764-0573 147 µM -0.183234879836588 0.334168944119736 no 2262 0.427306863747287 2729 1609797
SGTC_871 0574-0004 149 µM -0.183353018768978 0.334126036152983 no 2263 0.42726051823545 2738 9551173
SGTC_45 0kpi-0036 14.9 µM -0.183945892271982 0.333910737713295 no 2264 0.427027951097061 2854 2795021
SGTC_719 2810-4230 27.3 µM -0.18464330882131 0.333657545065177 no 2265 0.42675440721335 2717 721079
SGTC_574 1315-0397 40 µM -0.185549479833013 0.333328678579189 no 2266 0.42639903734171 2717 6794277
SGTC_3097 9117246 49.47 µM -0.186996592004283 0.332803760049961 no 2267 0.425831652501444 2722 16423892
SGTC_2092 5303694 80.6725 µM -0.187405819228242 0.332655378295053 no 2268 0.425671230175335 2759 1963699
SGTC_2505 galangin 7.89 µM -0.188567766086281 0.332234210762617 no 2269 0.425215799232144 2702 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1046 2001-0062 216 µM -0.188803313923646 0.332148858218146 no 2270 0.425123487211091 2709 739778
SGTC_2886 9058944 51.95 µM -0.188853394891869 0.332130712121917 no 2271 0.425103860833575 2724 4949929
SGTC_2367 9070478 135.38 µM -0.190470292780435 0.331545064857835 no 2272 0.424470309984664 2732 572802
SGTC_2108 5365811 200 µM -0.191492586168769 0.331174998137772 no 2273 0.424069844223741 2846 780283
SGTC_2273 7815444 169.05 µM -0.191745057185122 0.331083629858013 no 2274 0.423970955122454 2950 2824616
SGTC_726 3448-4391 34.2 µM -0.192553798938282 0.330791017093069 no 2275 0.423654215394889 2921 1356692
SGTC_2346 9031566 143.75 µM -0.193175336696048 0.330566207278509 no 2276 0.423410826697702 2868 4771086
SGTC_1735 st034310 56.75 µM -0.193470256677079 0.33045955628293 no 2277 0.423295348854218 2953 871153
SGTC_2739 tacrine 100.86 µM -0.195721669341242 0.329645839187499 no 2278 0.422414011373497 2848 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2473 5854593 8.94 µM -0.197481154915063 0.329010477568577 no 2279 0.421725513628536 2706 2872951
SGTC_943 3253-1379 105 µM -0.199967960927808 0.328113318084095 no 2280 0.420752819246138 2913 668464
SGTC_1686 st019653 115.5 µM -0.200507884550708 0.327918661758563 no 2281 0.420541696112973 2862 97252
SGTC_1015 4130-4525 82 µM -0.200657034990823 0.327864897433097 no 2282 0.420483378726911 2773 1363237
SGTC_91 0417-1751 58.384 µM -0.201416364494857 0.32759123692277 no 2283 0.420186510197533 2730 6795624
SGTC_2885 9057732 51.95 µM -0.202596724065774 0.327166022076802 no 2284 0.419725125360934 2913 6471414
SGTC_368 fentichlor 4.58 µM -0.202841078405734 0.32707802342779 no 2285 0.419629624680469 2846 7329 A pesticide.
SGTC_701 4424-0219 185 µM -0.203811739090315 0.326728557070948 no 2286 0.419250309461136 2908 2911779
SGTC_2124 5246320 200 µM -0.203900003058737 0.326696786982522 no 2287 0.419215821344337 2864 579342
SGTC_940 3232-1287 54.8 µM -0.203995362381132 0.326662464375979 no 2288 0.419178561498215 2757 1585493 YIL048W NEO1
SGTC_1225 1216-0074 20.6 µM -0.205318802242485 0.326186271268041 no 2289 0.418661527456144 2797 4241466
SGTC_210 3551-0445 56.827 µM -0.206979225260331 0.325589227324959 no 2290 0.418013041512862 2907 2865180 YOR207C RET1
SGTC_1057 3448-5381 134 µM -0.207180572530945 0.325516858574074 no 2291 0.417934419513161 2908 5497911
SGTC_2944 9067346 25.62 µM -0.207996437686765 0.325223685577242 no 2292 0.417615874422279 2927 6473075
SGTC_1232 0279-0259 161 µM -0.208431890715092 0.325067254133011 no 2293 0.417445878946482 2798 1560000
SGTC_665 3914-0008 307 µM -0.208811667345641 0.324930848956697 no 2294 0.417297631442194 2788 1069549
SGTC_1546 5-methoxyflavanone 78.7 µM -0.209723129375391 0.324603572980291 no 2295 0.416941886169694 2858 147795
SGTC_1106 tegaserod maleate 11.7 µM -0.212341331992385 0.323664216421404 no 2296 0.415920376142883 2828 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_675 1309-0189 238 µM -0.212778730064423 0.323507396359021 no 2297 0.415749777398291 2817 4246530
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.218262149078264 0.321544096516023 no 2298 0.413612432074078 2799 2724 A muscle relaxant with antifungal properties.
SGTC_100 0086-0128 49.5915 µM -0.218835468984042 0.321339109638902 no 2299 0.413389108098264 2830 93297
SGTC_98 0074-0023 107.663 µM -0.21919042954937 0.321212223018304 no 2300 0.413250855169387 2876 3563821
SGTC_47 0149-0135 24.25 µM -0.222039903023604 0.320194388021907 no 2301 0.412141410213545 2773 5239155
SGTC_323 4013-0906 34.3 µM -0.224512287432236 0.319312344225485 no 2302 0.41117935347467 2903 2910086
SGTC_2280 7785178 200 µM -0.224575717479418 0.319289728446983 no 2303 0.411154678510294 2807 2954328
SGTC_2764 methyldopa 94.69 µM -0.224706444909017 0.319243120125028 no 2304 0.411103825255718 2948 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1074 carmofur 3.8 µM -0.22633964847503 0.318661074136747 no 2305 0.410468631689006 2811 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1071 trifluoperazine 6.31 µM -0.22708862737016 0.318394300238215 no 2306 0.410177413551382 2971 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_529 4076-0302 30.3 µM -0.228609733370284 0.317852797283273 no 2307 0.409586129380878 2818 5816522
SGTC_1091 telmisartan 47.6 µM -0.229721011947644 0.317457435993546 no 2308 0.409154283167664 2912 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2389 9091542 195.52 µM -0.229883683675188 0.317399579476929 no 2309 0.409091077679534 2874 3626624 YOL127W RPL25
SGTC_489 paxilline 115 µM -0.233230271219145 0.316210309566201 no 2310 0.407791300445518 2872 105008 A toxic potassium channel blocker.
SGTC_1076 itraconazole 331 nM -0.233945605960442 0.315956348432187 no 2311 0.407513603502262 2803 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_841 0251-0215 91.2 µM -0.233985847787067 0.315942064189304 no 2312 0.407497982779669 2883 3888614
SGTC_1714 st033236 13.627 µM -0.234026524732751 0.315927625775803 no 2313 0.40748219330582 2986 2916566
SGTC_990 3985-0011 41.3 µM -0.23408027768344 0.315908546422734 no 2314 0.407461328380571 2878 5399565 YGL099W LSG1
SGTC_1338 1486-1223 76 µM -0.234427182745188 0.315785425925257 no 2315 0.407326678867601 2893 3444526
SGTC_1695 st026914 34.495 µM -0.234712473249791 0.315684188439115 no 2316 0.407215952949998 2792 3289191
SGTC_766 1391-0721 126 µM -0.235625056131746 0.315360444418367 no 2317 0.406861814417634 3004 1020919 YIL115C NUP159
SGTC_54 0159-0055 9 µM -0.237704215091098 0.314623380341819 no 2318 0.406055257098624 3069 3319099
SGTC_1415 3966-0071 78.1 µM -0.24271033461776 0.312851737807596 no 2319 0.404114900471128 2840 2893185
SGTC_686 1319-0111 510 µM -0.242856073397079 0.312800225957718 no 2320 0.404058447638974 3003 4562600
SGTC_2116 5511452 16.8835 µM -0.242940311736579 0.312770453307111 no 2321 0.404025818299855 2964 870744
SGTC_3044 9093193 49.47 µM -0.243250699796167 0.312660762313455 no 2322 0.403905596656112 2942 25236277
SGTC_985 1493-0307 8.71 µM -0.244214000922418 0.312320437828767 no 2323 0.403532542067149 2963 3278274
SGTC_2746 daunorubicin 9.88 µM -0.244973114317772 0.312052363527262 no 2324 0.403238624422682 2823 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1989 st071868 50.2 µM -0.245582539697415 0.311837222245891 no 2325 0.403002703338827 2974 16414057
SGTC_3188 9110789 49.47 µM -0.246292963785962 0.311586507110221 no 2326 0.402727728153697 3001 849217
SGTC_1340 1486-1359 257 µM -0.24664578235411 0.311462026668089 no 2327 0.402591184845627 2856 4309068
SGTC_1660 st012960 28.1 µM -0.247204051256615 0.311265103853836 no 2328 0.402375155070117 2942 24207266
SGTC_3071 9117417 49.47 µM -0.248383923728918 0.310849095379411 no 2329 0.401918685463104 2913 45595590 YGL055W OLE1
SGTC_1048 3161-0300 24.5 µM -0.249248313756653 0.310544475452959 no 2330 0.401584354705546 2834 2165101
SGTC_3056 9094900 49.47 µM -0.251951139808106 0.309592810431983 no 2331 0.400539415213562 2891 25236784
SGTC_2906 7926292 26.41 µM -0.252868734768442 0.309270014877116 no 2332 0.4001848252395 2983 2966319
SGTC_1758 st042942 75.2445 µM -0.253397519476016 0.30908406350486 no 2333 0.399980522147793 2846 669317
SGTC_2561 acetosyringone 100 µM -0.253689704886732 0.308981335142437 no 2334 0.399867644118294 2821 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_39 0986-0283 58.349 µM -0.254244655245077 0.308786263381913 no 2335 0.399653276913274 3018 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1745 st081495 74 µM -0.25431734684966 0.308760715397971 no 2336 0.399625199710709 2847 13842402 YBL026W LSM2
SGTC_689 0833-0039 98 µM -0.254812164321126 0.308586832857406 no 2337 0.399434089783061 2890 5374726
SGTC_140 0062-0056 502.533 µM -0.256075868422493 0.308142952657619 no 2338 0.398946127539977 2822 3758964
SGTC_315 k915-0449 187 µM -0.256185767179993 0.308104363606112 no 2339 0.398903699073166 2893 20970215 YNL149C PGA2
SGTC_2449 5812982 45.77 µM -0.257633291253356 0.307596288619674 no 2340 0.398344967049805 2904 776185
SGTC_462 ag-879 158 µM -0.257957319261695 0.30748260661309 no 2341 0.398219923483059 2975 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1275 0867-0008 21.1 µM -0.259110446859443 0.307078193291126 no 2342 0.397775012283471 2844 3422836
SGTC_1369 1866-0067 208 µM -0.260255381658423 0.306676885322848 no 2343 0.397333393610832 3003 3531355
SGTC_380 3970-0968 6 µM -0.260486865911883 0.306595776545809 no 2344 0.397244122604747 2880 2891601
SGTC_1382 3002-2117 298 µM -0.261410641608147 0.306272193079691 no 2345 0.396887925730042 3023 1497314
SGTC_739 1486-1183 203 µM -0.263011586050401 0.305711766328969 no 2346 0.396270824521511 2994 4346692
SGTC_1186 1319-0216 26 µM -0.263197871858585 0.305646584614965 no 2347 0.396199035503365 3022 4565136
SGTC_2862 9027634 71.43 µM -0.264350236545129 0.305243507231583 no 2348 0.395755026695923 2835 5012562
SGTC_3167 9103034 49.47 µM -0.264964162197756 0.305028862927948 no 2349 0.395518534887772 2847 5127859
SGTC_2181 6316240 54.2555 µM -0.265379075947648 0.304883836307805 no 2350 0.395358726721774 2963 12779990
SGTC_3091 9116372 49.47 µM -0.265703513485766 0.304770455584105 no 2351 0.395233778627633 3031 17169793
SGTC_200 k038-0079 37.545 µM -0.266346873537173 0.304545676919686 no 2352 0.394986038265212 2888 3436683
SGTC_2088 5278280 127.392 µM -0.266613884339172 0.304452409713312 no 2353 0.394883232165975 2962 791502
SGTC_264 promethazine 12.5 mM -0.267315001223203 0.30420756924759 no 2354 0.394613318796682 2909 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1341 1486-1360 280 µM -0.268048994757636 0.303951341787385 no 2355 0.394330802894522 2854 3976547
SGTC_2157 5649910 96.377 µM -0.26827420803884 0.303872742099439 no 2356 0.394244128889484 2882 2858091
SGTC_1692 fluoroquinolonic acid 71 µM -0.268369667813534 0.3038394292668 no 2357 0.394207392489577 3001 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_816 0325-0417 81.3 µM -0.273935459028387 0.301899945433969 no 2358 0.39206711055344 2949 68101
SGTC_2085 5307070 144.047 µM -0.274821333558079 0.301591762930988 no 2359 0.391726753572544 2861 2840351
SGTC_3135 9127742 49.47 µM -0.275464512811551 0.301368099196203 no 2360 0.391479693108853 2949 3643468
SGTC_3176 9106582 49.47 µM -0.275662484066713 0.30129927029485 no 2361 0.391403656441534 2963 17018027
SGTC_3299 9121982 43.1275 µM -0.276673425955637 0.300947905352584 no 2362 0.391015439311599 2920 17594604 YPL160W CDC60
SGTC_59 0330-0160 1.33 µM -0.279431824191381 0.299990132227708 no 2363 0.38995672558584 2928 4293482
SGTC_2560 caryophyllene 100 µM -0.280779776096516 0.299522597574341 no 2364 0.389439658110335 2867 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2081 5214970 32.255 µM -0.28394655399649 0.298425508024799 no 2365 0.388225669586512 3013 2063512
SGTC_2276 7947513 42.08 µM -0.284415096391345 0.298263342943615 no 2366 0.388046145627415 2987 2105100
SGTC_1493 4348-0038 111 µM -0.286771314371511 0.29744845198461 no 2367 0.387143714317292 2958 800424
SGTC_2698 st077697 67.5 µM -0.287328952164563 0.297255743507664 no 2368 0.386930228115788 2948 3154499
SGTC_1438 4092-1045 4 µM -0.287845850837516 0.29707716462956 no 2369 0.386732369034881 2921 1351342
SGTC_3332 9141069 11.198 µM -0.288825676471156 0.296738787807516 no 2370 0.386357391054676 2886 17332883
SGTC_2889 9059656 51.95 µM -0.288888073001062 0.296717245523222 no 2371 0.386333515574865 3010 3949838
SGTC_88 0180-0332 8.668 µM -0.292013278388505 0.295639191666611 no 2372 0.385138235773143 2881 3101745
SGTC_2387 9077560 195.08 µM -0.292172665383777 0.295584258679005 no 2373 0.38507730505252 2926 5303272
SGTC_3055 9094636 49.47 µM -0.292278211085423 0.295547884763774 no 2374 0.385036958430951 3094 25236176
SGTC_1200 1643-0193 18.4 µM -0.292503089582143 0.2954703923913 no 2375 0.384950998990664 3009 5403974
SGTC_1951 sophoraflavanone G 9.2 µM -0.293695679951737 0.295059586047723 no 2376 0.384495227854352 2931 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2763 lisinopril 49.32 µM -0.293897822003595 0.294989981149807 no 2377 0.384417991220435 2931 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_12 0849-0099 9.267 µM -0.294704204460094 0.294712389502619 no 2378 0.384109925530082 2984 6071388
SGTC_2066 5222451 176 µM -0.295023017330414 0.294602673590529 no 2379 0.38398814828624 2910 2281147
SGTC_3164 9100705 49.47 µM -0.296735007997999 0.294013833539571 no 2380 0.383334413812338 3073 17174235
SGTC_3184 9108758 49.47 µM -0.298067949877603 0.293555744597285 no 2381 0.382825651316903 2876 902885
SGTC_1937 st074714 47.2 µM -0.298405836944088 0.293439676286966 no 2382 0.382696717328319 2884 17250970
SGTC_1602 st001878 87.6 µM -0.298672668820353 0.29334803132336 no 2383 0.382594906404554 3106 595405 YLR310C CDC25
SGTC_659 k018-0002 107 µM -0.299055573066375 0.293216543805072 no 2384 0.382448821713772 3066 6797879 YHR007C ERG11
SGTC_1990 st072050 59.8 µM -0.299283266859422 0.293138367783927 no 2385 0.382361960464703 2916 17233948
SGTC_1297 1068-0111 14.1 µM -0.300056728234963 0.292872881008346 no 2386 0.382066942537552 2934 767057
SGTC_203 k066-0004 30.888 µM -0.300856015268946 0.292598647020229 no 2387 0.381762145973881 2995 6795412
SGTC_577 r071-0003 38.6 µM -0.300958409102059 0.292563524497116 no 2388 0.381723104856659 2945 4568517 YMR134W ERG29
SGTC_1098 clofazimine 15.1 µM -0.301231030605805 0.29247002104466 no 2389 0.381619164540757 3054 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_533 1222-0222 6.71 µM -0.302527167858586 0.292025663304841 no 2390 0.381125113079608 3114 3982874
SGTC_3137 9097352 49.47 µM -0.302731700411583 0.291955571657327 no 2391 0.38104716863501 3234 44120435
SGTC_1370 2001-0092 44.6 µM -0.30279422648061 0.291934146044035 no 2392 0.381023341803147 3169 790957
SGTC_1899 st063254 59.6 µM -0.303270804150969 0.291770862724034 no 2393 0.380841747005735 2900 3093813
SGTC_2193 5925765 200 µM -0.30451648888186 0.291344271828468 no 2394 0.380367216276961 3056 877370
SGTC_933 2914-0560 114 µM -0.305635965842572 0.290961149903723 no 2395 0.379940916618315 3134 463887
SGTC_1322 1348-1070 12 µM -0.306773429338874 0.290572113685238 no 2396 0.379507917012054 3050 6758089
SGTC_2474 5321570 43.32 µM -0.307520955056848 0.290316576920148 no 2397 0.379223437721963 3073 2841384
SGTC_1618 st003135 44.5 µM -0.30930605617753 0.289706777929866 no 2398 0.378544362269519 2998 1270615
SGTC_121 0557-0495 61.343 µM -0.309649638590885 0.289589477569799 no 2399 0.378413702051416 2954 3104427
SGTC_433 pimozide 108 µM -0.310118244474914 0.289429529669696 no 2400 0.378235519336425 2892 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_283 0987-0079 11.7 µM -0.311091562587712 0.289097442475922 no 2401 0.377865507610429 3058 411556
SGTC_1806 st050005 60.3 µM -0.311879108602325 0.288828870239104 no 2402 0.377566200046513 2959 5194765
SGTC_1466 k213-0079 57.5 µM -0.31268394877421 0.28855452167999 no 2403 0.377260395769618 2955 3657981
SGTC_791 1348-1292 225 µM -0.315619625375926 0.28755486991475 no 2404 0.376145619838712 3007 5437054
SGTC_2953 9074162 66.49 µM -0.316160094144594 0.287371008991117 no 2405 0.375940497801149 3081 16451992
SGTC_70 0141-0289 43.283 µM -0.318405874397768 0.286607618038298 no 2406 0.375088541425636 3037 352408
SGTC_164 4100-3994 89.624 µM -0.31962318471509 0.286194229392823 no 2407 0.3746269983803 3076 4615967
SGTC_1402 3909-7673 35.9 µM -0.31966798405038 0.2861790213086 no 2408 0.374610016139844 2908 5328014
SGTC_1774 st048371 48.465 µM -0.320046993981215 0.286050373714664 no 2409 0.37446635325719 2952 4242727
SGTC_2096 5468907 200 µM -0.322081621247846 0.285360228977716 no 2410 0.373695430574241 3087 759785
SGTC_71 0417-1750 47.813 µM -0.323126611686043 0.285006077175223 no 2411 0.373299678582191 3173 6811472
SGTC_1613 st002381 52.1 µM -0.32318541337456 0.28498615525757 no 2412 0.373277413555597 3004 551167
SGTC_1408 3909-7976 48.8 µM -0.325214873479183 0.284298984748417 no 2413 0.372509226300576 3014 24152374
SGTC_3217 9129673 49.47 µM -0.32716324295215 0.283640017402037 no 2414 0.371772210147954 3162 17248312
SGTC_2255 7941087 197.44 µM -0.329318434904586 0.282911953031101 no 2415 0.370957505753245 3125 935561
SGTC_758 0868-0029 16 µM -0.329335622721389 0.282906150272118 no 2416 0.370951010743645 3101 762687
SGTC_2670 beta-carotene 100 µM -0.329338090994537 0.282905316965964 no 2417 0.370950078024493 3094 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3315 9136395 68.55 µM -0.329563787875643 0.282829125113476 no 2418 0.370864794151951 3194 16876844
SGTC_1807 st050092 58.9 µM -0.329606386791206 0.28281474546984 no 2419 0.370848698050471 3000 5008496
SGTC_2837 9008476 45.46 µM -0.331602302098918 0.282141400464568 no 2420 0.370094790515644 3171 2992805
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.331855688815673 0.282055972778689 no 2421 0.369999115590621 2964 3256 An antibiotic and ribosome inhibitor.
SGTC_1534 6-azauridine 81.6 µM -0.332797860277492 0.281738435098533 no 2422 0.369643436757938 2988 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1560 lithocholic acid 53.1 µM -0.333416475193642 0.281530038628847 no 2423 0.369409964272977 3059 9903 A bile acid which acts as a detergent.
SGTC_114 0364-0001 490.298 µM -0.334200780372468 0.281265932045808 no 2424 0.369114027582672 3043 4003655
SGTC_2655 perillic acid 100 µM -0.334806183087175 0.281062150837367 no 2425 0.368885648008361 3009 5702197 An apoptosis inducer.
SGTC_2636 apigenin dimethyl ether 100 µM -0.336088492322023 0.280630755622438 no 2426 0.368402068004668 3142 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1059 3448-6867 171 µM -0.336161663918996 0.280606148856044 no 2427 0.36837448006362 3004 3934407
SGTC_865 0488-0499 301 µM -0.336437341657626 0.280513450980418 no 2428 0.368270547178435 3161 9634651
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.338587228018326 0.279791050980306 no 2429 0.367460352721473 2998 6708784 An antioxidant flavonoid
SGTC_3173 9105693 49.47 µM -0.338825328588419 0.279711100506513 no 2430 0.367370659639589 3161 17096658
SGTC_1242 0402-0103 60.1 µM -0.340175905000633 0.279257807829892 no 2431 0.366862031175258 2972 432868
SGTC_2125 5246583 200 µM -0.341364666567467 0.278859120541685 no 2432 0.366414535638036 3161 835267
SGTC_2479 5617353 43.85 µM -0.341719435587745 0.278740191663713 no 2433 0.366281022096631 3171 2731746
SGTC_1594 piperine 70.1 µM -0.342942756339523 0.2783302884821 no 2434 0.365820762583312 2998 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2626 ethyl orsellinate 100 µM -0.344613035918402 0.2777710958355 no 2435 0.365192652120462 2990 75653 A natural product.
SGTC_2160 5660466 132.927 µM -0.346280920701491 0.277213252931246 no 2436 0.36456580288184 3102 2859134
SGTC_2821 7996764 71.43 µM -0.346341196227532 0.277193103365917 no 2437 0.364543156005252 3239 2987135
SGTC_3337 9144342 33.5465 µM -0.347139015921862 0.276926466957532 no 2438 0.364243441696176 3112 17682949
SGTC_2208 7283366 200 µM -0.34781936594054 0.276699188913655 no 2439 0.363987922393644 3097 898663
SGTC_870 0573-2213 57.6 µM -0.348566783447633 0.27644961167802 no 2440 0.363707284226415 3015 3916321
SGTC_466 geldanamycin 89.2 µM -0.349430173738753 0.276161446359077 no 2441 0.363383191940402 3053 5288382 HSP90 inhibitor.
SGTC_1102 cgs 12066b 26.1 µM -0.350103635596312 0.27593677399402 no 2442 0.363130461272615 3059 6438352 A 5-HT1B full agonist.
SGTC_2416 tofa 880 nM -0.350144297767895 0.275923211636712 no 2443 0.363115203847371 3014 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2190 6049624 200 µM -0.35092435573361 0.275663096497476 no 2444 0.362822549409696 3108 2265554
SGTC_641 4092-0595 30 µM -0.35184805777731 0.275355238329988 no 2445 0.362476107602961 3101 786260
SGTC_397 arbidol 50 µM -0.351905075939463 0.275336240445829 no 2446 0.36245472617359 3163 131410 A RNA synthesis inhibitor.
SGTC_473 2-arachidonoylglycerol 10 µM -0.352730641107011 0.27506124265527 no 2447 0.362145192864507 2972 5282280 An endocannabinoid.
SGTC_3212 9128307 49.47 µM -0.353791383792327 0.274708105354103 no 2448 0.361747615579615 2943 27243542
SGTC_408 cantharidin 100 µM -0.353977617100946 0.274646128544543 no 2449 0.361677828800506 3055 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_111 0083-0039 52.457 µM -0.354293857306866 0.27454090238174 no 2450 0.361559335375588 2984 759313
SGTC_1387 3342-1166 1.8 µM -0.354608396205723 0.274436262048048 no 2451 0.361441492589386 3081 3418228
SGTC_2792 7535235 81.82 µM -0.355057921827534 0.274286748707465 no 2452 0.361273099506234 3093 1281891
SGTC_396 dithiazanine 1.25 µM -0.355285615888581 0.274211032444585 no 2453 0.361187815165187 3032 10578 An antihelmenthic.
SGTC_1293 1000-1278 195 µM -0.355304212860049 0.274204848755203 no 2454 0.361180849849215 3165 678847
SGTC_1252 0493-0875 34.8 µM -0.357736014618042 0.273396842831827 no 2455 0.360270439271789 3008 3960963
SGTC_2312 7706453 155.7 µM -0.358331889834971 0.273199033525966 no 2456 0.360047477891032 3057 976098
SGTC_1277 0873-0036 22 µM -0.359094600732097 0.272945944241928 no 2457 0.359762160302339 3135 5965735
SGTC_1391 3442-0225 151 µM -0.360260022560997 0.272559448630361 no 2458 0.359326346140303 3014 5227075
SGTC_507 nimesulide 162 µM -0.36331404228948 0.27154791699375 no 2459 0.358185152386163 3243 4495 A COX2 inhibitor.
SGTC_2539 epi(13)torulosol 80 µM -0.364669099620045 0.271099703682943 no 2460 0.35767921368836 3144 6708597
SGTC_2403 6032726 181.2 µM -0.364739944728341 0.271076280347379 no 2461 0.35765276906947 3113 2881040
SGTC_1372 2752-0194 270 µM -0.364760732405872 0.271069407562678 no 2462 0.35764500970489 3041 823334
SGTC_2215 7188065 200 µM -0.365151042076076 0.27094038021641 no 2463 0.357499330713535 3160 940217
SGTC_3283 9109332 35.8195 µM -0.366846376144358 0.270380297870412 no 2464 0.356866806231661 3065 17027281
SGTC_542 3381-0244 89.3 µM -0.368523430684167 0.269826824430733 no 2465 0.35624148871031 3204 1112843
SGTC_1457 k015-0032 57.3 µM -0.368682177039082 0.269774463236157 no 2466 0.356182317498967 3040 4302660
SGTC_648 0375-0473 33.3 µM -0.368688815402282 0.269772273736867 no 2467 0.356179843186921 3051 1713139
SGTC_2100 5377183 190 µM -0.369603985915704 0.26947051266581 no 2468 0.35583879038642 3122 2844202
SGTC_1253 0550-0034 176 µM -0.36982724195365 0.269396923668707 no 2469 0.355755607975982 3170 5969915
SGTC_1169 aniline yellow 25.8 µM -0.370374551530768 0.26921656373397 no 2470 0.355551716327882 3071 6051 A DNA damaging agent.
SGTC_370 0180-0345 38.7 µM -0.370856929558335 0.269057651520951 no 2471 0.355372048177371 2957 3989527
SGTC_1673 st016611 27.3 µM -0.370870912517114 0.269053045746895 no 2472 0.355366840516422 3230 5226799
SGTC_1190 1486-1332 13 µM -0.371514349310482 0.268841150260993 no 2473 0.355127235149306 3112 4150046
SGTC_3341 9147222 25.867 µM -0.374260156292177 0.267937848830674 no 2474 0.35410538612122 3189 1939759
SGTC_439 amiodarone 34.4 µM -0.375078642667466 0.267668883413025 no 2475 0.353800990082022 3071 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1938 st074717 56.4 µM -0.375350873191891 0.267579455038908 no 2476 0.353699767929586 3002 17250979
SGTC_84 0443-0269 128.823 µM -0.37574871550828 0.267448789989811 no 2477 0.353551858758881 3178 6150058
SGTC_1616 st002734 56.1 µM -0.376003712560904 0.267365057146443 no 2478 0.353457067994054 3058 4026101
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.376686757510384 0.267140832295344 no 2479 0.353203202582356 3004 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_567 1080-0542 68.4 µM -0.378432151558977 0.266568299020621 no 2480 0.352554793749663 3144 5950415
SGTC_1968 st069590 43.6 µM -0.380533377787366 0.265879867939297 no 2481 0.351774762411071 3186 6384066
SGTC_1254 0550-0035 264 µM -0.380729020180441 0.26581581491119 no 2482 0.351702166407126 3204 15121435
SGTC_1668 st014914 51.6 µM -0.381114851348766 0.265689517286745 no 2483 0.351559013894048 3149 2839556
SGTC_426 0988-0037 14.6 µM -0.38112627447382 0.265685778515153 no 2484 0.351554775964486 3259 5383008
SGTC_3145 9085516 49.47 µM -0.381254150090788 0.265643926839581 no 2485 0.351507335927881 3160 25236195
SGTC_253 dyclonine 31.25 µM -0.381398123318004 0.265596810670941 no 2486 0.351453926674515 3110 3180 An oral anasthetic.
SGTC_1413 3910-0535 34.4 µM -0.384620755687412 0.264543293808639 no 2487 0.350259207074174 3202 2876951
SGTC_3199 9111318 49.47 µM -0.385327629109016 0.264312493134903 no 2488 0.349997346946176 3180 8548020
SGTC_636 0kpi-0074 126 µM -0.385415604578527 0.264283775510356 no 2489 0.349964761562151 3133 616434
SGTC_856 0433-0016 11.3 µM -0.38599321854067 0.264095265817168 no 2490 0.349750845593429 3165 3911780
SGTC_413 propylparaben 100 µM -0.386210547323871 0.264024356286285 no 2491 0.349670371487277 3069 7175 A pharmaceutical preservative.
SGTC_2623 humulene 100 µM -0.386559900521938 0.263910390472213 no 2492 0.349541024562861 3148 6187145 An anti-inflammatory.
SGTC_351 caspofungin 25 nM -0.386757352399114 0.263845988919599 no 2493 0.349467926350372 3104 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1629 st005085 44.9 µM -0.386773413202719 0.263840750827564 no 2494 0.34946198076208 3056 24207091
SGTC_1175 0741-0056 27.6 µM -0.386827658031806 0.263823059738189 no 2495 0.349441900008741 3272 765927
SGTC_2278 7948257 134.34 µM -0.387043559508447 0.263752652895912 no 2496 0.349361980174566 3202 1247028
SGTC_299 1273-0059 1.44 µM -0.388046832422957 0.263425605002215 no 2497 0.348990688239234 3183 2848077
SGTC_2482 5981709 142.65 µM -0.38841562014263 0.263305439273889 no 2498 0.348854243333451 3115 877755
SGTC_3278 9139605 49.47 µM -0.388834725096075 0.263168912177037 no 2499 0.348699205670793 3260 7958859
SGTC_2478 5763493 32.33 µM -0.390814598282399 0.262524440541694 no 2500 0.347967141797185 3072 1365576 YLR208W SEC13
SGTC_2257 7960413 200 µM -0.391054874623354 0.262446282816263 no 2501 0.347878337400385 3066 2974689 YIL048W NEO1
SGTC_2909 7941780 10.49 µM -0.391220858733312 0.26239229802298 no 2502 0.347816995747103 3243 1243215
SGTC_2912 7964298 10.93 µM -0.391854158607354 0.262186375357909 no 2503 0.347582987891224 3172 2975850
SGTC_1671 st016596 74.5 µM -0.391903413654561 0.262170363145148 no 2504 0.347564790307571 3127 2829167
SGTC_2192 5915882 198.485 µM -0.393556422654866 0.261633280895101 no 2505 0.346954279791445 3124 2876149
SGTC_3018 9082602 49.47 µM -0.393902691855835 0.261520845495242 no 2506 0.346826441452274 3174 17332089
SGTC_1698 5-fluorocytosine 1.055 µM -0.395049795906967 0.261148552161401 no 2507 0.346403069337658 3223 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1849 st056239 19.2 µM -0.396019361841054 0.260834091480448 no 2508 0.346045372390021 3079 5393181
SGTC_2307 7538926 6.34 µM -0.396129390423877 0.26079841806647 no 2509 0.346004788784241 3125 96582
SGTC_916 4466-0038 42 nM -0.397424313804473 0.260378767320075 no 2510 0.34552729445708 3316 5722064 YGL116W CDC20
SGTC_281 1672-3440 14.9 µM -0.397518412649402 0.260348285911528 no 2511 0.34549260570469 3203 6833000
SGTC_2335 9018011 154.17 µM -0.397815961863786 0.260251912988252 no 2512 0.345382925214383 3176 6458208
SGTC_389 tpck 16.7 µM -0.398046534457796 0.260177245700778 no 2513 0.345297942100196 3170 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1486 3970-0793 4.53 µM -0.398150872293279 0.26014346117218 no 2514 0.345259488426732 3191 2844330
SGTC_2182 6325192 200 µM -0.398429078591685 0.260053389194325 no 2515 0.345156963400114 3203 736248
SGTC_259 usnic acid 108.925 µM -0.398445855448597 0.260047958038878 no 2516 0.345150781129415 3298 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3104 9120930 49.47 µM -0.398882768541308 0.259906537188686 no 2517 0.344989793239203 3194 17014836
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.401496213473857 0.259061441550062 no 2518 0.344027412702281 3076 6312947
SGTC_171 k064-0041 9.68 µM -0.40185195003145 0.258946518899767 no 2519 0.343896493431646 3111 53325
SGTC_1845 st056753 3.01 µM -0.403138710589468 0.258531044150533 no 2520 0.343423092196012 3065 5375839
SGTC_772 k072-0172 35.3 µM -0.403893700249664 0.258287430670649 no 2521 0.343145444553457 3117 5861980
SGTC_73 0327-0325 16.231 µM -0.403982162161121 0.258258894341045 no 2522 0.343112918200507 3206 53298
SGTC_2109 5483026 200 µM -0.405377831430463 0.257808891196746 no 2523 0.342599901811934 3159 759335
SGTC_958 1222-0007 33 µM -0.405386852592324 0.257805983843912 no 2524 0.342596586780253 3275 7312461
SGTC_1087 pterostilbene 9.05 µM -0.405394825013077 0.257803414495012 no 2525 0.342593657142504 3232 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1222 0366-0074 1.18 µM -0.407238562948104 0.257209572415167 no 2526 0.341916390538824 3242 286520
SGTC_1258 0671-0043 57.1 µM -0.408972586048249 0.256651717572067 no 2527 0.341279889683657 3175 4298767
SGTC_3287 9117173 37.0625 µM -0.409426048480328 0.256505937570786 no 2528 0.341113513424444 3161 2789709
SGTC_359 0081-0058 15.9 µM -0.41005513558542 0.25630376885576 no 2529 0.340882751279225 3467 3494159
SGTC_891 0929-0073 133 µM -0.410472699687159 0.256169622825192 no 2530 0.340729613001486 3236 5603632
SGTC_2828 7998861 71.43 µM -0.411276829468948 0.255911392447803 no 2531 0.340434778825025 3217 2988188
SGTC_1017 4239-0030 168 µM -0.413937197332314 0.255058036999525 no 2532 0.339460050652164 3153 1149593
SGTC_1840 st055363 71 µM -0.414433547234751 0.254898989775944 no 2533 0.339278312337033 3172 676033
SGTC_730 1436-0052 41.2 µM -0.414872587673906 0.254758349707328 no 2534 0.339117589013016 3178 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_363 0455-0021 3.06 µM -0.414878485661605 0.254756460651365 no 2535 0.339115430084943 3107 4597466
SGTC_2034 5197015 53.07 µM -0.415074863504679 0.254693567329663 no 2536 0.339043550001736 3276 780676
SGTC_220 paclitaxel 373.376 µM -0.416140169678569 0.254352526772591 no 2537 0.338653718675866 3220 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_431 k089-0097 107 µM -0.418212641428239 0.253689744857517 no 2538 0.337895826976826 3212 5499420
SGTC_3261 9137475 49.47 µM -0.419236999874741 0.253362487578156 no 2539 0.337521466946317 3163 17027690
SGTC_403 arphamenine a 50 µM -0.419698864456578 0.253215005841487 no 2540 0.337352727376117 3172 5487158 An arginine aminopeptidase inhibitor.
SGTC_3065 9113888 49.47 µM -0.419739427374474 0.253202055523046 no 2541 0.337337909509108 3322 16648368
SGTC_2037 5169046 200 µM -0.421027776832838 0.252790911966806 no 2542 0.336867399415438 3246 5718022
SGTC_995 3931-2021 34.6 µM -0.421535797854342 0.252628886817445 no 2543 0.336681938323438 3218 730143
SGTC_900 1112-0045 141 µM -0.4223037122229 0.252384076730652 no 2544 0.336401674458439 3182 56211 YIL048W NEO1
SGTC_2646 retinol 96.75 µM -0.423486905102417 0.252007121306763 no 2545 0.33597002531459 3238 445354 A vitamin A analog and teratogen.
SGTC_2444 5485484 36.41 µM -0.42383628235468 0.251895869455568 no 2546 0.335842607803922 3255 6790631
SGTC_2472 5377652 49.4 µM -0.424650824924749 0.251636596179935 no 2547 0.335545618287578 3188 1610903
SGTC_710 3448-4187 58 µM -0.426941919541769 0.25090808497721 no 2548 0.334710815934882 3194 3946412
SGTC_2291 7917025 104.35 µM -0.427280240656041 0.250800601935645 no 2549 0.334587611504391 3104 2964612
SGTC_457 grayanotoxin iii 135 µM -0.428761647965135 0.250330252948229 no 2550 0.334048345897229 3245 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1367 1812-0510 76.9 µM -0.428794569622816 0.250319805588003 no 2551 0.334036365558548 3200 1142582 YDR527W RBA50
SGTC_1130 3454-2858 15.9 µM -0.430036768825452 0.24992577500929 no 2552 0.333584447379294 3188 715628 YIL048W NEO1
SGTC_1831 st055328 12 µM -0.432642074142649 0.249100432110231 no 2553 0.332637409075431 3274 1103068
SGTC_1892 st058411 7.36 µM -0.432935689696996 0.249007507705254 no 2554 0.332530745510378 3265 3934738
SGTC_43 0570-0105 72.5 µM -0.433544919318177 0.248814755591257 no 2555 0.33230947010222 3159 1114046 YDL195W SEC31
SGTC_1077 5-fluorocytosine 377 nM -0.433906284030301 0.248700462166625 no 2556 0.332178248141658 3222 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2180 6301957 200 µM -0.433918300892504 0.248696661920812 no 2557 0.332173884825412 3271 845462
SGTC_1499 4480-0877 67.3 µM -0.434280761057196 0.248582051049099 no 2558 0.332042286428315 3172 2861909
SGTC_535 2293-4129 48.2 µM -0.435093335604298 0.248325215088966 no 2559 0.331747340310033 3301 396118 YIL048W NEO1
SGTC_2717 st081029 62.2815 µM -0.43562912430676 0.248155942136317 no 2560 0.331552918198434 3276 5292846
SGTC_1561 5-methoxyflavone 52.9 µM -0.438535521335852 0.247238790835659 no 2561 0.330499063183848 3229 94525
SGTC_835 0312-0010 67.2 µM -0.439011517867417 0.247088756868316 no 2562 0.330326595319412 3143 1626196
SGTC_1451 4152-0210 104 µM -0.439658118456025 0.246885026592797 no 2563 0.330092370203405 3318 659563
SGTC_520 3584-0023 682 µM -0.440035744554524 0.246766086133694 no 2564 0.329955609412338 3198 1340790
SGTC_2079 5212404 121 µM -0.440514842599433 0.246615229335519 no 2565 0.329782132320502 3314 758462
SGTC_2480 5767542 37.17 µM -0.442182047398235 0.24609065070176 no 2566 0.329178738021533 3183 2867358
SGTC_2859 9028643 45.46 µM -0.446307220769415 0.244795259875163 no 2567 0.327687670533282 3217 17151580
SGTC_2205 7238770 200 µM -0.446848537647576 0.244625547885357 no 2568 0.327492211581899 3302 279867
SGTC_2703 st077852 53.4 µM -0.447396944015675 0.244453677855305 no 2569 0.327294240960315 3293 6281836
SGTC_182 3448-4371 550.524 µM -0.447768756508185 0.244337189195271 no 2570 0.327160047038292 3303 3491403
SGTC_306 1672-3436 11.6 µM -0.450238503128324 0.243564178813155 no 2571 0.326269238094505 3277 6797378
SGTC_586 0957-0265 8.15 µM -0.451303337946681 0.243231302230051 no 2572 0.325885469718263 3258 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1146 3579-1023 7 µM -0.451573926416129 0.243146753136091 no 2573 0.325787978515211 3313 X1146
SGTC_2025 5147754 141 µM -0.451764001870732 0.243087370945869 no 2574 0.325719502731395 3235 315777 YLR208W SEC13
SGTC_1909 st060837 51.5 µM -0.452179344054231 0.242957639624082 no 2575 0.325569893767395 3203 678937
SGTC_3045 9092950 49.47 µM -0.452286775281996 0.242924089787324 no 2576 0.325531200910857 3339 44120432
SGTC_2974 9094440 9.66 µM -0.454328940401378 0.2422868163411 no 2577 0.324796044574739 3352 25236134
SGTC_3202 9113761 49.47 µM -0.456282621331471 0.241678004072247 no 2578 0.324093379614622 3314 4798415
SGTC_734 2023-0417 80 µM -0.457350906594131 0.241345453143895 no 2579 0.323709422550186 3278 3935732
SGTC_150 3970-0969 77.2 µM -0.45793831863165 0.241162701220393 no 2580 0.323498378122062 3308 6615640
SGTC_2397 5161689 200 µM -0.458994056194087 0.240834435996243 no 2581 0.323119217196535 3388 2259942
SGTC_2801 7907800 81.82 µM -0.45948897175942 0.240680633410848 no 2582 0.322941534874596 3279 6620925
SGTC_2047 4141938 200 µM -0.459550662726455 0.24066146574681 no 2583 0.322919389697061 3217 3807862
SGTC_1529 apigenin 74 µM -0.460153578115816 0.240474180942392 no 2584 0.322702994502757 3409 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1628 st004252 77.7 µM -0.463119135126354 0.239554140490435 no 2585 0.321639487444689 3323 692968
SGTC_2569 tetrandrine 100 µM -0.464111275103752 0.239246766503914 no 2586 0.321284012023207 3212 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2625 euphol 100 µM -0.464180817921477 0.239225229591039 no 2587 0.321259101549754 3347 6708538 A triterpene alcohol.
SGTC_1567 st069303 68.4 µM -0.464776302880679 0.239040855540591 no 2588 0.321045829747378 3307 5581319
SGTC_749 1000-0129 128 µM -0.465835703315918 0.23871303610222 no 2589 0.320666553436522 3383 708470
SGTC_117 lucigenin 22.078 µM -0.467350575218037 0.238244703844313 no 2590 0.320124538816926 3305 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2004 4023728 41.89 µM -0.468637978178067 0.237847091035579 no 2591 0.319664213085725 3363 360084 YDR527W RBA50
SGTC_1948 st076329 66.6 µM -0.470247355659758 0.237350549024564 no 2592 0.319089152213595 3262 24208413
SGTC_2782 7736369 71.43 µM -0.470858920983888 0.237162011834962 no 2593 0.318870742416328 3244 2950836 YOL077C BRX1
SGTC_2435 5706476 10.6 µM -0.471436783303137 0.236983940446107 no 2594 0.318664426834951 3355 5725375
SGTC_2461 5755302 26.15 µM -0.472907764906319 0.236530981348445 no 2595 0.318139492445289 3347 2788904
SGTC_1335 1486-0900 202 µM -0.475152793226944 0.235840589568537 no 2596 0.317339035804094 3275 X1335
SGTC_2513 baicalein 25.65 µM -0.475452706475429 0.235748444347047 no 2597 0.317232167382501 3262 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1428 4049-0204 61.7 µM -0.476225767274629 0.235511021030688 no 2598 0.316956772044815 3346 X1428
SGTC_1443 4112-3303 14 µM -0.479073427284102 0.234637583555005 no 2599 0.315943196477538 3264 704433
SGTC_1423 4048-0112 5.59 µM -0.479610846579778 0.234472946876941 no 2600 0.315752066135079 3324 X1423
SGTC_974 1326-0144 138 µM -0.480057095193041 0.234336288627076 no 2601 0.315593397596041 3257 5411856
SGTC_2187 6125751 200 µM -0.480076396409247 0.234330378857361 no 2602 0.315586535605703 3288 874498
SGTC_336 4111-0029 111 µM -0.480203629812982 0.234291423784927 no 2603 0.315541303032445 3262 3131175
SGTC_934 2950-0684 338 µM -0.480607036650568 0.234167936348829 no 2604 0.31539790669389 3397 1121253
SGTC_444 curcumin 90.4 µM -0.480698647562452 0.234139898225402 no 2605 0.315365346246577 3350 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1388 3346-4487 254 µM -0.481746108108928 0.233819448194904 no 2606 0.314993158683202 3330 3345614
SGTC_589 1227-0070 34.1 µM -0.482463698070674 0.233600055973592 no 2607 0.31473829031633 3356 2841384
SGTC_2812 7970281 58.44 µM -0.483426914119222 0.233305746837339 no 2608 0.314396320974617 3375 2233435
SGTC_3162 9099653 49.47 µM -0.483729149990029 0.233213441575508 no 2609 0.314289051368467 3346 25237511
SGTC_1708 st033234 31.827 µM -0.483842700134144 0.23317876768885 no 2610 0.31424875418435 3385 674664
SGTC_811 0416-0114 265 µM -0.48455207982637 0.232962214961093 no 2611 0.313997056472894 3359 6612453
SGTC_513 4245-1575 41.7 µM -0.484773842914558 0.232894540146532 no 2612 0.313918389609756 3271 719745
SGTC_2183 6420625 130.508 µM -0.485034291271163 0.232815073804768 no 2613 0.313826010572643 3357 2897619
SGTC_1621 st003705 32.4 µM -0.485100532229818 0.232794865189268 no 2614 0.31380251727316 3377 24207032
SGTC_46 0329-0187a 2.197 µM -0.485105930133815 0.232793218454023 no 2615 0.313800602862887 3317 46494817
SGTC_2113 5491891 107.031 µM -0.48536174776223 0.232715183750404 no 2616 0.313709880822834 3285 789979
SGTC_1495 4469-0029 237 µM -0.486792967595137 0.232278872221119 no 2617 0.313202527224848 3320 793680
SGTC_428 3448-4153 16.5 µM -0.486885011175008 0.23225082805336 no 2618 0.313169910749977 3169 3834874
SGTC_1736 st036774 51 µM -0.486946622075829 0.232232057275989 no 2619 0.313148079186759 3446 1272247
SGTC_1480 1070-0044 41.2 µM -0.487142768986937 0.232172303505907 no 2620 0.313078579717027 3325 3124987
SGTC_2239 6685329 187.64 µM -0.488780318672166 0.231673777974093 no 2621 0.312498616631012 3355 805680
SGTC_2345 9052315 157.45 µM -0.489119424780538 0.231570617205069 no 2622 0.312378575008481 3332 6469265
SGTC_1494 4358-1428 177 µM -0.489858696675113 0.231345809249275 no 2623 0.312116946012389 3393 1564571
SGTC_2635 hydroquinidine 100 µM -0.489959838004465 0.231315062272416 no 2624 0.312081159368052 3278 442912 An experimental heart treatment.
SGTC_252 miconazole 1.30953 nM -0.490561230573269 0.231132285932608 no 2625 0.311868406409501 3326 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1287 0971-0001 34.6 µM -0.49130594588287 0.230906062414193 no 2626 0.311605037547728 3339 4665869
SGTC_1183 1254-0324 198 µM -0.49138975154685 0.230880612357244 no 2627 0.31157540567075 3380 5799357
SGTC_2277 7947813 106.88 µM -0.494346216435012 0.229983797681782 no 2628 0.310530845375987 3436 1246798
SGTC_788 1182-0090 188 µM -0.494789890201561 0.229849382032056 no 2629 0.310374220720555 3430 5715185
SGTC_237 nikkomycin 200 µM -0.494889533419047 0.229819200117071 no 2630 0.310339049636219 3408 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1780 st038448 24.544 µM -0.495318178535723 0.229689388886381 no 2631 0.310187770473508 3399 728868 YDL195W SEC31
SGTC_1128 3448-9350 235 µM -0.495972724530789 0.229491244910072 no 2632 0.309956827432472 3287 619386
SGTC_2323 6148992 148.28 µM -0.49678989048811 0.229244007157046 no 2633 0.309668612513295 3245 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1483 3453-0561 55.9 µM -0.499197509991699 0.228516438467118 no 2634 0.308820124291889 3361 4546991
SGTC_1246 0422-0085 105 µM -0.499443045451014 0.228442312030999 no 2635 0.308733650406186 3407 264295
SGTC_1160 4092-0570 10.5 µM -0.499604380867518 0.228393612697148 no 2636 0.308676836278245 3283 4994975
SGTC_1081 sertraline 6 µM -0.500420907465579 0.22814723243329 no 2637 0.308389367398107 3395 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2481 5478948 45.16 µM -0.502041960259804 0.227658536065316 no 2638 0.307819002687268 3387 77792
SGTC_1363 1636-0063 10.4 µM -0.502674484840881 0.227468009777273 no 2639 0.307596575756715 3308 6072185
SGTC_1273 0849-0096 14.1 µM -0.503391952119859 0.22725200617212 no 2640 0.307344364367061 3326 5286025
SGTC_2753 fluvastatin 17.09 µM -0.503417408650118 0.227244344250035 no 2641 0.307335417301283 3327 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_600 1495-0418 41.6 µM -0.504033675593417 0.227058904274845 no 2642 0.307118856366183 3302 5377768
SGTC_630 4356-0227 183 µM -0.505091099858261 0.22674091518664 no 2643 0.30674742610596 3362 779312
SGTC_2856 9022925 19.48 µM -0.507087932594528 0.226141112629217 no 2644 0.30604656087472 3378 4944862
SGTC_480 am 92016 50 µM -0.509907645486565 0.2252956648719 no 2645 0.305058082695372 3342 2129 K+ channel blocker.
SGTC_2988 9073640 71.4286 µM -0.513484780281011 0.224225696087336 no 2646 0.303806127219908 3461 9102229
SGTC_2349 9023730 187.07 µM -0.513679396373937 0.224167566692859 no 2647 0.303738079647915 3427 4126287
SGTC_2788 5282734 71.43 µM -0.5139356808216 0.22409103078871 no 2648 0.303648480095666 3428 743706
SGTC_740 k014-0057 261 µM -0.514295175697463 0.223983697494545 no 2649 0.303522817054328 3362 4012779
SGTC_343 4130-2827 29.8 µM -0.514541396917496 0.223910200828808 no 2650 0.3034367627297 3327 1118244
SGTC_1915 st067105 30.6 µM -0.515192818321844 0.223715818621179 no 2651 0.303209143511803 3390 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2321 7390090 138.78 µM -0.516252556366936 0.223399801025377 no 2652 0.302839013800009 3307 649046
SGTC_1344 1488-0097 29.1 µM -0.516985944164364 0.223181251007816 no 2653 0.302582985408507 3388 747966
SGTC_1312 1218-2183 165 µM -0.517781727546479 0.222944244817478 no 2654 0.302305284283224 3416 6744073
SGTC_3041 9091929 49.47 µM -0.517979188370522 0.222885457758458 no 2655 0.302236394933747 3469 25236887
SGTC_2490 carminic acid 95.39 µM -0.518793534825094 0.222643107894971 no 2656 0.301952363438161 3390 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2977 9011197 71.43 µM -0.5189478778723 0.222597192275077 no 2657 0.301898544481177 3456 2704722
SGTC_1442 4112-3290 3 µM -0.51990445154378 0.222312740950433 no 2658 0.301565086295735 3333 704353
SGTC_2333 9017922 200 µM -0.520120900695152 0.222248405377755 no 2659 0.301489655884409 3406 3163164
SGTC_1412 3909-8563 178 µM -0.520215111307607 0.22222040630565 no 2660 0.301456827059972 3437 23767530
SGTC_2935 9038016 29.96 µM -0.522314863599003 0.221596889683629 no 2661 0.300725560971445 3443 6463195
SGTC_2702 st077768 96.8 µM -0.523812977991822 0.221152639892386 no 2662 0.300204312942812 3361 6484119
SGTC_1970 st070122 35.8 µM -0.523859569393729 0.221138831885609 no 2663 0.300188108665134 3462 102928
SGTC_1011 4112-3381 17.4 µM -0.524270790308391 0.221016982267844 no 2664 0.30004510505428 3475 2877139
SGTC_2967 9089538 49.85 µM -0.52638924139342 0.220389869371142 no 2665 0.299308894616327 3458 728216
SGTC_216 k038-0035 28.382 µM -0.526887598241977 0.220242491985472 no 2666 0.299135823284799 3379 4444231 YPR107C YTH1
SGTC_1419 3993-2473 62.6 µM -0.529527183364549 0.219462839352517 no 2667 0.298219896193473 3384 704026
SGTC_2429 5902844 64.44 µM -0.529778679771355 0.219388637837512 no 2668 0.298132694473662 3385 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_684 1140-0066 328 µM -0.530736051411095 0.219106306771479 no 2669 0.297800849916878 3398 6813534
SGTC_229 benomyl 22.8748 µM -0.531572760852833 0.218859730428417 no 2670 0.297510967375265 3408 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2664 lyso-paf C-16 73.48 µM -0.531783367358617 0.218797690336346 no 2671 0.297438021905359 3334 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3211 9128781 49.47 µM -0.532909633555619 0.218466088640178 no 2672 0.297048068124758 3341 17194361
SGTC_2229 7354935 190 µM -0.533431938787609 0.218312406848702 no 2673 0.296867306699802 3381 318112
SGTC_1509 1326-1131 80 µM -0.539240597760161 0.216607484312368 no 2674 0.294860425450991 3402 768313
SGTC_1606 st000094 49.2 µM -0.540106559735506 0.21635397374155 no 2675 0.294561773557874 3473 1242210
SGTC_1626 st003712 1.76 µM -0.543544650703441 0.215349167821151 no 2676 0.293377428424469 3447 24207035
SGTC_1901 st060216 58.6 µM -0.543695080772601 0.215305265505795 no 2677 0.293325659062507 3403 688792
SGTC_786 4544-0069 423 µM -0.544840141583742 0.214971255109664 no 2678 0.292931733943953 3417 748821 YLR208W SEC13
SGTC_2342 7990637 118.86 µM -0.545737869404761 0.214709601487 no 2679 0.292623068396142 3445 2033102 YER133W GLC7
SGTC_1520 flindersine 88 µM -0.547373610519357 0.214233321086088 no 2680 0.292061040738314 3524 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_534 k292-0788 63.4 µM -0.54893412664973 0.213779517438468 no 2681 0.291525328599518 3479 4146317
SGTC_3291 9121177 71.43 µM -0.549335723021433 0.213662822423419 no 2682 0.291387538099892 3364 17015612
SGTC_1706 st031321 9.9705 µM -0.550142394734966 0.213428533645414 no 2683 0.291110855301363 3441 6103185
SGTC_2127 5253358 187.912 µM -0.550290197142933 0.213385622326808 no 2684 0.291060173404629 3345 20612
SGTC_3207 9114163 49.47 µM -0.551963513425568 0.212900161053505 no 2685 0.290486675825944 3550 849233
SGTC_1812 st052057 4.327 µM -0.552133602219912 0.212850851134298 no 2686 0.290428410726242 3400 3645418
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.552272484862958 0.212810593038565 no 2687 0.290380839568515 3409 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_467 ro 31-8220 72.8 µM -0.552337838145988 0.212791650533804 no 2688 0.29035845551861 3349 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1552 6-methylflavone 10.6 µM -0.552600234205864 0.212715605525437 no 2689 0.290268590793249 3442 689013
SGTC_2243 6634756 200 µM -0.552918880487895 0.212623279976128 no 2690 0.290159479155944 3523 885676
SGTC_2075 5212009 200 µM -0.55368010262721 0.212402815896028 no 2691 0.289898897438627 3429 780898
SGTC_770 0389-1121 67.2 µM -0.554160061731165 0.212263879502319 no 2692 0.289734654176971 3523 6753108
SGTC_308 4092-1169 104 µM -0.555489523556122 0.211879310355983 no 2693 0.289279936999826 3414 2268590 YDL196W YDL196W
SGTC_3193 9111931 49.47 µM -0.556349469655546 0.211630773760828 no 2694 0.288985987520265 3397 17087244
SGTC_2887 9044784 58.44 µM -0.556760130959637 0.211512147062156 no 2695 0.288845663576155 3435 6465546
SGTC_2298 7976326 193.81 µM -0.560209796061132 0.21051718923767 no 2696 0.287668172989325 3377 2235818
SGTC_2933 9026794 32.47 µM -0.561236443052583 0.210221613331215 no 2697 0.287318181215368 3372 17586027
SGTC_1134 3477-0009 42.5 µM -0.56133846483273 0.210192254159208 no 2698 0.287283412222332 3549 3973534
SGTC_950 1165-0508 94.1 µM -0.561700215418072 0.210088171312044 no 2699 0.287160143776705 3418 6148369
SGTC_1003 4049-0218 100 µM -0.561738776222623 0.210077078386772 no 2700 0.287147005453365 3519 295161
SGTC_2065 5221596 34.26 µM -0.564181026778 0.209375208714287 no 2701 0.286315469427856 3457 788581
SGTC_736 0958-0254 92.6 µM -0.565691946916538 0.2089416825509 no 2702 0.285801605297625 3503 6812352
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.566373102910033 0.208746412481854 no 2703 0.285570087583549 3374 6708630 An antioxidant.
SGTC_2296 7971656 126.45 µM -0.566569296436472 0.208690188752367 no 2704 0.285503420041565 3424 666570
SGTC_3307 9126885 69.2785 µM -0.568724137820691 0.208073257399907 no 2705 0.284771682182238 3394 24824909
SGTC_1679 SEC14.276 6.7 µM -0.569694112167973 0.207795905336474 no 2706 0.284442592089512 3443 1005053 YMR079W SEC14
SGTC_1744 st037937 38.9 µM -0.571376153827225 0.207315464476887 no 2707 0.28387234496069 3503 1016152
SGTC_1866 st057638 64 µM -0.572144842331272 0.207096123145747 no 2708 0.283611925865511 3419 688802
SGTC_3328 9140624 29.0385 µM -0.57223278441295 0.207071038077318 no 2709 0.283582139823868 3483 4904392
SGTC_1625 st003711 30.1 µM -0.573074924815046 0.206830912501153 no 2710 0.283296982233243 3550 24207034 YER133W GLC7
SGTC_1570 verbenone 133 µM -0.573612703705067 0.206677657997138 no 2711 0.283114956624488 3515 29025 A natural terpanoid with antifungal properties.
SGTC_717 1532-0246 73.2 µM -0.575016097631688 0.206278040133015 no 2712 0.282640205028428 3441 9561992
SGTC_2279 7948423 32.93 µM -0.576062919678771 0.20598025490964 no 2713 0.282286326821718 3531 1247112
SGTC_2009 4012297 12.05 µM -0.579591251368015 0.204978444390064 no 2714 0.281095147073789 3460 45595307
SGTC_1390 3413-2614 145 µM -0.580572340350785 0.204700396185513 no 2715 0.280764359249078 3474 3421432
SGTC_1553 gossypol 38.6 µM -0.581765571425036 0.204362527821445 no 2716 0.280362298640465 3438 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_598 3937-0236 20.2 µM -0.582707574036892 0.204096030495815 no 2717 0.280045086812959 3495 1379313
SGTC_879 0831-1030 162 µM -0.583005586834616 0.204011764285028 no 2718 0.279944769629729 3527 1549252
SGTC_829 1635-0120 117 µM -0.584239325899482 0.203663132362872 no 2719 0.279529653394225 3494 285054
SGTC_1179 1021-1431 9.29 µM -0.584997033793088 0.203449194269968 no 2720 0.279274855619642 3451 2840958
SGTC_1067 clotrimazole 1.36 µM -0.585205154464828 0.203390455076689 no 2721 0.279204889726359 3463 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1919 st067113 52.3 µM -0.586195742252176 0.203111014040611 no 2722 0.27887199129788 3485 1268243
SGTC_538 2922-0838 53.3 µM -0.586801032512855 0.202940376844292 no 2723 0.278668671643992 3539 777039
SGTC_699 0375-0592 111 µM -0.587728271376134 0.202679145317419 no 2724 0.278357348082054 3535 762578
SGTC_623 k072-0108 16.9 µM -0.588795364472284 0.202378761417457 no 2725 0.277999277920059 3468 5382803
SGTC_941 3237-0776 460 µM -0.589042640196838 0.202309191964725 no 2726 0.277916334998659 3533 760008
SGTC_610 4215-0184 155 µM -0.590506159742398 0.201897732988482 no 2727 0.277425678666335 3509 5605015
SGTC_1647 st011722 22.4 µM -0.591484261369558 0.201623025598705 no 2728 0.277097998723062 3520 2854783
SGTC_3001 9076041 71.4286 µM -0.593199390495996 0.201141859244167 no 2729 0.276523860245687 3510 16004211
SGTC_3175 9106517 49.47 µM -0.593450096861009 0.201071583222452 no 2730 0.276439985317997 3482 41468073
SGTC_1333 1482-0047 286 µM -0.594219517818572 0.200855997208225 no 2731 0.27618265004718 3518 3811116
SGTC_1360 1598-0022 39.8 µM -0.595238914380069 0.200570583616639 no 2732 0.275841890821989 3504 761525
SGTC_1323 1348-1351 11.2 µM -0.596086348366362 0.200333502078628 no 2733 0.275558771793036 3417 6989654
SGTC_539 4859-0462 2.54 µM -0.597406229310806 0.199964582381622 no 2734 0.275118097881925 3526 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2050 5263056 171 µM -0.598237975575193 0.199732311089847 no 2735 0.27484057781639 3517 763468 YGL055W OLE1
SGTC_2831 7999036 19.48 µM -0.598419673037874 0.199681592340363 no 2736 0.274779971095913 3542 2988270
SGTC_196 k015-0023 18.111 µM -0.598659209475813 0.199614740351528 no 2737 0.274700081767595 3499 5211998
SGTC_1342 1486-1464 234 µM -0.599300791098725 0.199435748327334 no 2738 0.274486160219745 3543 3253938
SGTC_1881 5652484 16 µM -0.599334474473885 0.199426353821485 no 2739 0.274474931496721 3502 2255129
SGTC_1854 st056233 32.9 µM -0.600248423273522 0.199171549431119 no 2740 0.274170343173349 3490 5393174
SGTC_41 0478-0632 82.643 µM -0.600914328607261 0.19898602188081 no 2741 0.273948524562571 3549 3750424
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.601903071439109 0.198710740930119 no 2742 0.273619329820148 3520 61125 An anti-inflammatory.
SGTC_2588 indole-3-carbinol 100 µM -0.602320314079799 0.198594643203286 no 2743 0.273480470665761 3526 3712 Induces cell cycle arrest.
SGTC_862 0452-0056 10.2 µM -0.604366600914073 0.19802585664775 no 2744 0.272799967944243 3492 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_324 1315-0088 19.6 µM -0.605209169901401 0.197791942120812 no 2745 0.272520011846302 3492 6787421
SGTC_1315 1237-0019 3.69 µM -0.606798530818931 0.197351157490094 no 2746 0.271992311634054 3535 825140
SGTC_2584 androsterone 48.74 µM -0.60763992115554 0.197118051615105 no 2747 0.271713158767612 3587 2754130 A steroid.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.607748355471101 0.197088022182466 no 2748 0.271677193273327 3533 616764
SGTC_2582 agaric acid 100 µM -0.608214473391598 0.196958968593851 no 2749 0.271522618273963 3510 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3343 9148379 18.9835 µM -0.608649442642435 0.196838585258053 no 2750 0.271378412382685 3567 1955036
SGTC_67 0335-0847 266 µM -0.608905294735366 0.196767795715127 no 2751 0.271293607252513 3617 4552207 YOR254C SEC63
SGTC_2813 7971799 71.43 µM -0.609270175214875 0.196666866710305 no 2752 0.271172686260299 3530 2234054
SGTC_319 1348-1596 45.5 µM -0.610171922068113 0.196417570506132 no 2753 0.270873963656256 3582 5380505
SGTC_2564 betulinic acid 100 µM -0.610698424782291 0.196272102591927 no 2754 0.270699624531409 3590 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_493 zm226600 134 µM -0.610709404055901 0.196269069813818 no 2755 0.270695989596844 3573 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2840 9008771 71.43 µM -0.612155945258279 0.195869743747872 no 2756 0.27021729296392 3477 2992978
SGTC_2854 9024559 71.43 µM -0.613033882959717 0.195627624556665 no 2757 0.269926968012335 3503 3163529
SGTC_937 3122-0005 46.7 µM -0.613438447360101 0.195516114266883 no 2758 0.269793235303312 3539 759535
SGTC_967 1306-0166 352 µM -0.613926688548211 0.195381591515719 no 2759 0.269631886607549 3541 4437607
SGTC_1227 3909-8010 46.6 µM -0.614843093166571 0.195129250802557 no 2760 0.269329173645 3509 15982272
SGTC_1138 3761-0006 1.03 µM -0.615018795217593 0.195080892214697 no 2761 0.26927115403241 3534 12061087
SGTC_2365 9042475 200 µM -0.615033298599885 0.195076900765036 no 2762 0.269266365064927 3524 6464479
SGTC_304 1310-0298 97 µM -0.615222896486785 0.195024726439319 no 2763 0.269203764417372 3499 1550234
SGTC_2218 6965428 192.983 µM -0.616925393232908 0.19455660659214 no 2764 0.268641968390409 3528 675684
SGTC_1404 3909-7820 48.3 µM -0.617067513936742 0.194517559919942 no 2765 0.268595097543647 3547 23741373
SGTC_366 0181-0206 4.31 µM -0.61833466343314 0.194169630312286 no 2766 0.268177378411623 3589 274874
SGTC_2934 9036370 36.88 µM -0.618642056110785 0.194085284639623 no 2767 0.268076094908195 3519 6462800
SGTC_272 doxorubicin 8.13 µM -0.619414142019722 0.19387352995645 no 2768 0.267821783538144 3558 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2694 st077685 81.9 µM -0.619580967079288 0.193827794503175 no 2769 0.267766850301324 3514 2838096
SGTC_38 0929-0051 58.268 µM -0.619630652753384 0.193814174338585 no 2770 0.267750490577811 3520 1379719
SGTC_2533 agelasine 13.65 µM -0.625252095930363 0.19227695641893 no 2771 0.265902807521873 3613 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2959 9079155 11 µM -0.625796712327212 0.192128425010306 no 2772 0.265724144270452 3557 16189457
SGTC_2772 vinpocetine 57.06 µM -0.628253009666849 0.191459399958889 no 2773 0.264919104585199 3605 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_819 1013-0258 27.7 µM -0.629681048607272 0.191071100051613 no 2774 0.264451642116196 3576 5753198
SGTC_184 1494-0393 24.714 µM -0.630476183634896 0.190855103326452 no 2775 0.264191540115107 3553 3090647
SGTC_1751 st044839 27.194 µM -0.630563448211686 0.190831407217473 no 2776 0.26416300234537 3581 5291326
SGTC_715 0868-0130 184 µM -0.634950071104404 0.189642576309316 no 2777 0.26273048957271 3626 2876258
SGTC_2390 9097792 176.6 µM -0.636276646143844 0.189283956630298 no 2778 0.262298061938019 3496 4497149
SGTC_2035 5154463 94.595 µM -0.636777415443097 0.189148689773058 no 2779 0.262134919504484 3581 2769623
SGTC_228 caffeine 993.056 µM -0.637965961337244 0.188827880385682 no 2780 0.261747918999265 3577 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1996 st072960 66.8 µM -0.638847099575671 0.188590262284945 no 2781 0.261461202327141 3591 1719405
SGTC_2805 7950783 58.44 µM -0.639261911154892 0.188478463167721 no 2782 0.261326281178549 3560 1178958 YDL195W SEC31
SGTC_563 tetrahydrosecaminediol 614 µM -0.639466094810122 0.188423447045817 no 2783 0.261259881769193 3630 334274 A psychoactive constituent of the cannabis plant.
SGTC_214 4373-3496 70 µM -0.63963436793792 0.188378114256558 no 2784 0.26120516678331 3650 3779166
SGTC_716 1683-5115 658 µM -0.640663760611785 0.188100942299415 no 2785 0.260870582003841 3616 723597
SGTC_2630 antimycin a 100 µM -0.64408609969685 0.187181261822274 no 2786 0.259759801788618 3580 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2819 7996655 46.38 µM -0.644222918767707 0.187144552522309 no 2787 0.259715445550617 3471 6456960
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.653227942031722 0.184738253793769 no 2788 0.25680466949904 3583 140250 A respiratory chain inhibitor.
SGTC_1741 st038134 10.228 µM -0.654237227946401 0.184469758935174 no 2789 0.256479490225622 3672 1272587
SGTC_1006 4099-6547 255 µM -0.654491096774371 0.184402261812011 no 2790 0.256397730649251 3609 3146833
SGTC_2861 9024595 19.48 µM -0.654544869799002 0.184387966934438 no 2791 0.256380414552585 3554 16482810
SGTC_1958 st076513 41.9 µM -0.655887492465862 0.184031271229159 no 2792 0.255948258180099 3548 732122 YGL099W LSG1
SGTC_2275 7947463 200 µM -0.656017787420703 0.183996678541096 no 2793 0.255906339762245 3571 1225414
SGTC_875 0709-0210 25.7 µM -0.656183536892414 0.183952678699751 no 2794 0.255853020115585 3626 6251364
SGTC_972 1319-0219 195 µM -0.656746175797339 0.183803369496108 no 2795 0.255672069083958 3573 23903702
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.658776564343826 0.183265187089047 no 2796 0.255019629322524 3670 5393153
SGTC_1345 1488-0192 31.4 µM -0.658840621369906 0.18324822389954 no 2797 0.254999059587852 3627 658348
SGTC_989 1501-0895 10.3 µM -0.661431073860636 0.182563056764527 no 2798 0.254167951806969 3605 2830112
SGTC_680 0417-1641 114 µM -0.661963263135828 0.182422492619935 no 2799 0.253997382945416 3592 2835990
SGTC_2013 4024628 200 µM -0.662349460415777 0.182320530862314 no 2800 0.253873642737986 3630 5230760
SGTC_970 1315-0089 19.5 µM -0.662744876224826 0.182216172181004 no 2801 0.253746981642463 3569 6811083 YLR033W RSC58
SGTC_1820 st053765 18.6 µM -0.664834950638709 0.181665177288377 no 2802 0.253078032665604 3602 3690829
SGTC_3114 9122766 49.47 µM -0.665020066294356 0.181616426568074 no 2803 0.253018829325223 3565 17176985
SGTC_3230 9131665 49.47 µM -0.665391033000709 0.18151875610389 no 2804 0.252900209388823 3559 15943720
SGTC_2068 5226020 147 µM -0.673503316103166 0.179391128818815 no 2805 0.250313569898062 3664 1810509
SGTC_1498 4478-3555 97.6 µM -0.674734188684925 0.179069680458918 no 2806 0.249922329578543 3612 3437919
SGTC_278 4092-0821 23.9 µM -0.675165338151868 0.178957169431832 no 2807 0.249785362897518 3626 877900
SGTC_2483 5729050 27.16 µM -0.676720932342999 0.178551597754819 no 2808 0.249291516407918 3676 2865180
SGTC_543 3844-1095 191 µM -0.678626020322044 0.178055695976403 no 2809 0.248687425809252 3642 4230703
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.680495236829088 0.177569976525317 no 2810 0.248095468389412 3599 4620898
SGTC_3020 9089140 49.47 µM -0.681339205906985 0.177350943840267 no 2811 0.247828440481738 3649 17217859
SGTC_3228 9131799 49.47 µM -0.681573968381479 0.177290046999781 no 2812 0.247754190006243 3622 17015818
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.682130775051404 0.177145665449151 no 2813 0.247578131172914 3479 4000243
SGTC_2094 5332512 191.667 µM -0.682478153936246 0.177055626751519 no 2814 0.247468325977568 3677 755774
SGTC_1895 st058434 18.3 µM -0.684173958471068 0.176616498735064 no 2815 0.246932662184572 3658 5393175
SGTC_1112 tnp00069 1.16933 µM -0.684662613923348 0.176490089499872 no 2816 0.246778422943435 3690 145826
SGTC_1728 st035614 33.7865 µM -0.684668832489489 0.176488481201138 no 2817 0.246776460447211 3649 15945546
SGTC_634 1611-4317 11.2 µM -0.685068732480685 0.176385075113876 no 2818 0.246650274911127 3662 2843522
SGTC_1305 1181-0477 144 µM -0.685184677549976 0.176355101222364 no 2819 0.246613695750228 3649 6252086
SGTC_2225 6654152 15.4 µM -0.685253564871787 0.176337294133556 no 2820 0.246591964072544 3600 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2362 9071156 126 µM -0.685722832403501 0.17621602068367 no 2821 0.246443952944177 3647 653133
SGTC_2391 6285546 200 µM -0.688459219771045 0.175509904059454 no 2822 0.245581821183624 3646 846083
SGTC_2371 9071574 200 µM -0.688877220599867 0.175402198300995 no 2823 0.245450267774845 3633 45596039
SGTC_708 3448-5400 146 µM -0.689215576215892 0.175315045319769 no 2824 0.245343808080621 3643 3462195
SGTC_2375 9072683 200 µM -0.689367779606805 0.175275850021758 no 2825 0.245295927132517 3706 16798029
SGTC_761 k216-0224 480 µM -0.690616331371445 0.174954533730477 no 2826 0.244903340793608 3697 1340404
SGTC_3277 9138724 49.47 µM -0.693563274789372 0.174197617643107 no 2827 0.24397806586528 3601 15943418
SGTC_2331 7980721 200 µM -0.693706838057441 0.174160796966112 no 2828 0.243933038406396 3652 2981221
SGTC_2616 abietic acid 100 µM -0.694209646483493 0.174031877171783 no 2829 0.243775371964351 3660 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1195 1502-0147 41.1 µM -0.694375968681333 0.173989245611902 no 2830 0.243723230156921 3673 817940
SGTC_2177 5811945 192 µM -0.697016068693141 0.173313426860491 no 2831 0.242896368894887 3694 5343475
SGTC_2436 5633522 8.09 µM -0.697071721957352 0.173299198623174 no 2832 0.24287895502336 3656 5724242
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.698301582115112 0.172984964087781 no 2833 0.242494305015146 3669 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_377 3970-0964 33.1 µM -0.700251903013123 0.172487393553467 no 2834 0.241885001451762 3669 16481235
SGTC_3339 9145883 14.936 µM -0.700361010251155 0.172459584839933 no 2835 0.241850939596857 3605 2030670
SGTC_2077 5212015 200 µM -0.700604451197492 0.172397548123194 no 2836 0.241774949894907 3587 780900
SGTC_3183 9108214 49.47 µM -0.701258353749656 0.172230982842114 no 2837 0.241570899421931 3584 4974831
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.70149010698217 0.172171974171402 no 2838 0.241498603211536 3670 521171
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.701840617122192 0.17208275230599 no 2839 0.24138928270875 3669 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.702349680154836 0.171953223589803 no 2840 0.241230559079729 3698 165506
SGTC_3272 9137413 49.47 µM -0.702750688311505 0.17185123277617 no 2841 0.241105566440345 3637 17614870
SGTC_2237 6667747 47.222 µM -0.703943187750375 0.171548165535335 no 2842 0.240734077262989 3631 729940 YDL015C TSC13
SGTC_549 1661-1316 519 µM -0.704500538061425 0.171406635171419 no 2843 0.240560557550238 3703 2857282
SGTC_622 1348-1566 26.3 µM -0.707513071490004 0.170642941986497 no 2844 0.239623846228193 3738 7340407
SGTC_1503 4585-0012 61.3 µM -0.708394241662629 0.170419973060182 no 2845 0.239350233685877 3690 2922052
SGTC_1008 4106-0037 6 µM -0.708554995166244 0.170379316560783 no 2846 0.239300336456281 3661 2905394
SGTC_2898 9056270 58.44 µM -0.709581559211886 0.17011983266209 no 2847 0.238981829230755 3633 19154699
SGTC_695 3505-6186 243 µM -0.709609620852059 0.170112743098188 no 2848 0.238973125932693 3688 1819379
SGTC_2102 5377816 72.7585 µM -0.709687900784993 0.170092967258319 no 2849 0.238948848382315 3696 1379702
SGTC_2691 st077356 60.2 µM -0.712557979651901 0.169368917395457 no 2850 0.238059660844249 3742 2839272
SGTC_1940 st075990 51.1 µM -0.715227321032782 0.168697286820045 no 2851 0.237234294773331 3782 1084979
SGTC_968 1309-0633 340 µM -0.716899786530707 0.168277352713552 no 2852 0.236717966853994 3684 3761976
SGTC_514 4466-0038 2.65 nM -0.719421233534979 0.167645522690478 no 2853 0.235940708883838 3648 5722064
SGTC_2848 9016370 25.97 µM -0.720518382456601 0.167371074264239 no 2854 0.235602942871347 3704 7894410
SGTC_2409 alverine citrate 63.97 µM -0.722388456484197 0.166903948739976 no 2855 0.235027841010329 3850 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1448 4255-0083 152 µM -0.722625629360746 0.166844765507548 no 2856 0.23495495894697 3742 5399660
SGTC_1979 st071809 45.3 µM -0.722929593103806 0.16676893532838 no 2857 0.234861570638973 3787 4976333
SGTC_3270 9137563 49.47 µM -0.72483237171779 0.166294752372326 no 2858 0.234277436829788 3707 17015724
SGTC_1882 5615643 20 µM -0.724908830827107 0.166275716554222 no 2859 0.234253981474212 3654 2253075
SGTC_2751 anetholtrithion 17.25 µM -0.725811165624247 0.166051171007494 no 2860 0.233977270510143 3707 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1697 st025554 27.742 µM -0.725856217106922 0.1660399651071 no 2861 0.233963459721282 3691 1269519
SGTC_2022 5136654 200 µM -0.725945962187169 0.166017643781262 no 2862 0.23393594920119 3729 1713771
SGTC_2139 5578692 56.4705 µM -0.726182258438124 0.165958881637612 no 2863 0.233863523354221 3653 650991 YMR113W FOL3
SGTC_2353 9059630 146.67 µM -0.72635917885765 0.165914893874205 no 2864 0.23380930459758 3757 4779114
SGTC_2014 4013930 200 µM -0.726812625818848 0.165802187664587 no 2865 0.233670373760496 3695 64556
SGTC_2971 9092186 9.93 µM -0.72796308840743 0.16551645733658 no 2866 0.233318090952472 3721 25236400
SGTC_863 0466-0191 129 µM -0.728802156342744 0.165308266349504 no 2867 0.233061346175514 3728 765160 YPR165W RHO1
SGTC_2525 harmine 47.85 µM -0.73320494949043 0.164218616508617 no 2868 0.231716718519123 3720 5280953 A monoamine oxidase inhibitor
SGTC_127 0180-0333 59.125 µM -0.733368036199037 0.164178343750055 no 2869 0.231666994458157 3669 771601
SGTC_3236 9132701 49.47 µM -0.734403091336868 0.163922895776344 no 2870 0.231351551643214 3738 24282524
SGTC_2876 9059903 25.97 µM -0.735011904202059 0.163772763426169 no 2871 0.2311661221268 3696 6916095
SGTC_1876 myriocin 605 nM -0.735571614742608 0.163634818404366 no 2872 0.230995721169346 3748 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2006 4011487 200 µM -0.73677695146265 0.163338010010823 no 2873 0.230629000883289 3784 45595294
SGTC_1988 st071872 53.4 µM -0.737349534940333 0.163197136682558 no 2874 0.230454908014473 3736 16414116
SGTC_1644 st010134 20.9 µM -0.740499679709985 0.162423515699055 no 2875 0.22949842772589 3736 3818134
SGTC_2948 9070189 9.45 µM -0.741415260684571 0.162199113267307 no 2876 0.229220847144781 3652 6473636 YDL196W YDL196W
SGTC_838 0109-0203 71.4 µM -0.742893452798005 0.161837245067876 no 2877 0.228773094943892 3751 759422
SGTC_3132 9126706 49.47 µM -0.745574763350558 0.161182191528765 no 2878 0.227962166275216 3756 850858
SGTC_808 0711-0032 135 µM -0.746896467072491 0.160859932087114 no 2879 0.227563029353741 3708 4252555
SGTC_2381 9035592 200 µM -0.750572086222629 0.159965951046145 no 2880 0.226455112763819 3767 4749657
SGTC_2700 st077718 96.8 µM -0.750589630626081 0.15996169171742 no 2881 0.226449831789231 3761 904970
SGTC_2743 auranofin 4.32 µM -0.751245966574173 0.159802403563712 no 2882 0.226252320555438 3705 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_416 estradiol valerate 100 µM -0.751665535740975 0.159700631443891 no 2883 0.226126110581207 3788 13791 A steroid.
SGTC_2710 st078562 53.7235 µM -0.752552366366138 0.159485658388743 no 2884 0.225859475355875 3731 17250908
SGTC_85 0868-0259 160.055 µM -0.753990356121252 0.15913748385132 no 2885 0.225427506293181 3737 83173
SGTC_2517 totarol 10 µM -0.756192245929306 0.158605314993462 no 2886 0.224766970563238 3749 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1105 epirubicin 18.1 µM -0.757560573570034 0.158275196152269 no 2887 0.224357045218703 3764 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_649 1123-0311 367 µM -0.758895690516446 0.15795352451531 no 2888 0.223957478541698 3737 693629 YIL048W NEO1
SGTC_2015 5119600 184 µM -0.759939984678858 0.157702220612313 no 2889 0.223645229770074 3771 2828786
SGTC_732 3970-1727 52.7 µM -0.760198883626161 0.157639958592218 no 2890 0.223567856102232 3785 1275699
SGTC_2786 7743617 45.45 µM -0.761131371734529 0.157415840496868 no 2891 0.223289302047672 3734 583674
SGTC_3073 9114972 49.47 µM -0.768128785568436 0.155740738083787 no 2892 0.221205338422647 3714 41905075
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.768474998120956 0.155658164982712 no 2893 0.221102519391237 3833 65057 A dermal irritant. YDR527W RBA50
SGTC_2730 imipramine 71.33 µM -0.769052606709344 0.155520467269143 no 2894 0.220931040697226 3780 3696 A tricyclic antidepressant.
SGTC_2563 tomatine 8.54 µM -0.771862090632814 0.154851852938515 no 2895 0.220098056094052 3731 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2629 bisabolol 100 µM -0.773309020705121 0.154508247518234 no 2896 0.219669759209461 3805 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2986 9022445 71.43 µM -0.774423880948455 0.15424384340854 no 2897 0.219340082951021 3711 6459286
SGTC_2847 9005661 71.43 µM -0.776700051155931 0.15370494867276 no 2898 0.218667878339757 3753 2991449
SGTC_154 3389-1638 511.116 µM -0.778377395529407 0.153308627627846 no 2899 0.218173280355814 3747 5238686
SGTC_2989 9073649 71.4286 µM -0.779578837579513 0.153025168773572 no 2900 0.217819408162242 3748 21367202
SGTC_1932 st074806 40.9 µM -0.779774470075115 0.152979045683498 no 2901 0.217761818014862 3865 17251235
SGTC_3011 9081274 71.4286 µM -0.780413206166286 0.152828518915272 no 2902 0.217573848531294 3798 6625322
SGTC_1373 2887-0003 58.5 µM -0.781197812486444 0.152643750337545 no 2903 0.217343080058854 3806 776948
SGTC_430 0958-0115 16.4 µM -0.781537569368634 0.152563786279895 no 2904 0.217243194607779 3784 6833180
SGTC_2941 9056145 11.23 µM -0.782452363013882 0.152348621655946 no 2905 0.216974385388708 3676 2119517
SGTC_223 busulfan 5 mM -0.783583999582576 0.152082733185286 no 2906 0.21664212370418 3810 2478 A DNA alkylator.
SGTC_2254 7938975 95.19 µM -0.78416080757799 0.15194732546099 no 2907 0.216472879454409 3841 2969277
SGTC_1830 st055982 50.3 µM -0.784780188028403 0.151802012900118 no 2908 0.216291229013739 3723 455313 An antimicrobial agent.
SGTC_2993 9054257 71.4286 µM -0.785784064206145 0.15156669015205 no 2909 0.21599700206454 3783 6470217 YGL055W OLE1
SGTC_106 0092-0003 11.579 µM -0.786250765239205 0.151457371462459 no 2910 0.215860295243317 3765 1072148
SGTC_1779 st039427 55 µM -0.790706344426887 0.150416349453554 no 2911 0.214557686474238 3820 1124498
SGTC_81 0411-0046 9.971 µM -0.791453693005772 0.150242203479196 no 2912 0.21433964411011 3742 12925265
SGTC_1197 1601-0112 267 µM -0.79244528294536 0.150011352271475 no 2913 0.214050542242165 3808 7350313
SGTC_1018 4259-0013 28.1 µM -0.797470627389068 0.148845044181497 no 2914 0.212588877527215 3919 6801262
SGTC_1813 st051246 8.6015 µM -0.801330100059088 0.147953442400773 no 2915 0.211470284877779 3753 5291959
SGTC_839 0122-0028 230 µM -0.803505341739057 0.147452504246294 no 2916 0.210841355262052 3837 759448
SGTC_756 0508-1999 28.3 µM -0.805167797620667 0.147070422964146 no 2917 0.210361428265279 3835 6753853
SGTC_3042 9091578 49.47 µM -0.805424275854475 0.14701153588039 no 2918 0.210287443853824 3768 25236497
SGTC_1399 3562-5772 25 µM -0.806295041021081 0.146811727260691 no 2919 0.210036374581068 3783 23847490
SGTC_747 3448-8087 38.7 µM -0.806649446763544 0.146730456348943 no 2920 0.209934238592477 3876 5168703
SGTC_2175 5807670 165.306 µM -0.806941434929717 0.146663521470489 no 2921 0.209850112624146 3811 241186
SGTC_802 4112-3352 742 µM -0.808560046871951 0.146292845223813 no 2922 0.209384126883445 3944 704594
SGTC_3305 9127027 53.8275 µM -0.811670089371984 0.145582385415814 no 2923 0.208490480826646 3781 41905295
SGTC_2511 berberine 10.47 µM -0.811706210095597 0.145574147630348 no 2924 0.208480115052801 3829 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1045 1348-1485 165 µM -0.812346600171848 0.145428150655768 no 2925 0.208296389055159 3866 6810614
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.81342996358467 0.145181388337515 no 2926 0.207985792902836 3915 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2119 5528445 120.635 µM -0.813787911589355 0.14509991895194 no 2927 0.207883230702111 3865 791935
SGTC_1966 st070145 16.1 µM -0.818015558055929 0.144140029494578 no 2928 0.206674151784364 3814 3748532
SGTC_2412 st077135 33.4 µM -0.8245084443851 0.142674170600367 no 2929 0.204825359837017 3967 13258915
SGTC_158 k038-0087 26.446 µM -0.824511165351718 0.142673558424918 no 2930 0.204824587133267 3803 X158
SGTC_3061 glucosamine 200 µM -0.826340927043673 0.142262292432072 no 2931 0.204305361591914 3758 91431 and experimental redox chemotherapeutic
SGTC_495 decylubiquinone 155 µM -0.827282390681592 0.142050997412661 no 2932 0.204038511133297 3911 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2638 epoxomicin 18 µM -0.828030812631888 0.141883178852797 no 2933 0.203826525043593 3871 9915668 A protesome inhibitor.
SGTC_631 k072-0230 41.5 µM -0.828211481139417 0.141842687699311 no 2934 0.203775371434373 3892 5773147
SGTC_1368 1852-0141 284 µM -0.829536213450457 0.141546029743403 no 2935 0.20340052695992 3872 2838987
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.829681074917218 0.141513615267578 no 2936 0.203359562121495 3886 689007
SGTC_2795 7780010 54.55 µM -0.831479112479077 0.141111701640853 no 2937 0.202851511604917 3889 953673
SGTC_1274 0865-0114 173 µM -0.831899559001347 0.141017831400619 no 2938 0.202732820402384 3896 870624
SGTC_134 0269-0018 6.916 µM -0.832693735562011 0.140840636565733 no 2939 0.202508739219607 3837 4378915
SGTC_3157 9099274 49.47 µM -0.833058528361673 0.140759295491681 no 2940 0.202405860618843 3844 17217662
SGTC_417 st075190 100 µM -0.833736337459247 0.140608243062681 no 2941 0.202214788393132 3868 222757
SGTC_1004 4084-0029 199 µM -0.836906652414979 0.139903187001446 no 2942 0.201322520374001 3917 716894 YLR208W SEC13
SGTC_559 1550-0661 158 µM -0.837687044140394 0.139730002458485 no 2943 0.201103245854434 3949 5830875
SGTC_3072 9116419 49.47 µM -0.838541805605677 0.139540481094449 no 2944 0.200863239354703 3913 17170162
SGTC_418 lividomycin a 100 µM -0.839018059237242 0.139434959979467 no 2945 0.200729587792908 3848 72394 An antibiotic.
SGTC_2462 5162487 171.77 µM -0.839228986713904 0.139388243190234 no 2946 0.200670412051481 3789 2259986
SGTC_2413 inermin 26.06 µM -0.839284819345322 0.139375879010216 no 2947 0.200654749949886 4000 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1239 0337-0584 35.4 µM -0.839369346076001 0.139357161919293 no 2948 0.200631040011188 3957 914301 YML130C ERO1
SGTC_1773 st048542 73.5835 µM -0.842157621521331 0.138740701467905 no 2949 0.199849865697603 3838 3237138
SGTC_1908 st060353 56.5 µM -0.843698526794962 0.138400820413809 no 2950 0.199418945493456 3935 4227716
SGTC_568 1193-0097 7.48 µM -0.847077333472369 0.137657536929363 no 2951 0.198476009101989 3767 3646150
SGTC_2024 5144227 134 µM -0.8479506901682 0.137465856343156 no 2952 0.198232716336013 3972 3475211
SGTC_1738 st035555 74 µM -0.848391064520894 0.137369274006294 no 2953 0.198110108650076 3966 5331140
SGTC_2589 lobaric acid 100 µM -0.850315685041537 0.136947712572501 no 2954 0.197574799226611 3929 73157 A novel microtubule depolymerizer.
SGTC_3063 1327-0034 4 µM -0.851279134224292 0.136737014794172 no 2955 0.197307156472527 3803 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2809 7964133 12.99 µM -0.85218684797055 0.136538708718146 no 2956 0.197055197571063 3923 1253665
SGTC_1739 st037196 92.5 µM -0.853165814073278 0.136325056865337 no 2957 0.196783679143373 3963 612214
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.853605580071871 0.136229155797814 no 2958 0.196661782846858 3933 6710655
SGTC_625 k213-0058 121 µM -0.853839540839912 0.136178154101628 no 2959 0.196596951203706 3979 3655420
SGTC_1445 4239-0156 97.7 µM -0.853966090542414 0.136150572660095 no 2960 0.19656188907501 4000 4008346
SGTC_685 1278-0033 54.9 µM -0.854855382500066 0.135956859778667 no 2961 0.196315606834487 3925 3590572
SGTC_2745 rifampicin 24.3 µM -0.856153097107472 0.135674519654639 no 2962 0.195956551074085 3898 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2913 7966556 36.57 µM -0.857291066843606 0.135427265517259 no 2963 0.195642022128106 3780 2976516
SGTC_2447 5741742 33.78 µM -0.859439838915444 0.134961230233037 no 2964 0.195048949053907 3964 1776504
SGTC_1835 st008666 49.2 µM -0.863003722670014 0.134190706821912 no 2965 0.194067710088352 3855 690455
SGTC_1434 4073-0095 163 µM -0.863759639811662 0.134027664242374 no 2966 0.193859971756838 3875 24133745
SGTC_780 0109-0199 192 µM -0.863769360965296 0.134025568388877 no 2967 0.193857301108653 4007 610414
SGTC_249 wiskostatin 11.211 µM -0.865816613779574 0.133584688090677 no 2968 0.19329536843212 3892 2775510 A n-wasp and actin depolymerizer.
SGTC_64 000l-0018 272.079 µM -0.865837421661014 0.133580212194316 no 2969 0.19328966216489 3859 6811119
SGTC_2766 oltipraz 83.91 µM -0.86891703817715 0.132918905664377 no 2970 0.19244625477786 3870 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1237 0330-0133 46.1 µM -0.869113828891238 0.132876724240898 no 2971 0.192392436757957 3859 X1237 YHR072W ERG7
SGTC_262 fenpropimorph 62.5 µM -0.869508470270182 0.132792161974924 no 2972 0.192284538580733 3888 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2908 7930301 100 µM -0.871303313461021 0.13240803735816 no 2973 0.191794280884175 3925 2223178
SGTC_26 0302-0163 425.158 µM -0.8741372294152 0.131803095167378 no 2974 0.19102176249403 3986 3100915
SGTC_2396 5342950 42.78 µM -0.875278206273361 0.131560075646733 no 2975 0.190711274657803 3940 1886677
SGTC_2653 dihydrofissinolide 100 µM -0.878858087713812 0.130799595983249 no 2976 0.189739113065374 3980 6857746
SGTC_1176 0848-0131 83.3 µM -0.881236456978366 0.130296038413165 no 2977 0.189094925353486 3999 6769040
SGTC_3100 9120536 49.47 µM -0.881468409842798 0.13024700032804 no 2978 0.189032172466115 3782 16421196
SGTC_3158 9100007 49.47 µM -0.883552566667437 0.129806953194106 no 2979 0.188468897052659 3969 19297233
SGTC_1010 4112-3296 15.2 µM -0.883680750168755 0.129779922281987 no 2980 0.188434287313935 4034 704384
SGTC_2674 ligustilide 100 µM -0.883939917813028 0.129725281775817 no 2981 0.188364323634622 4001 5319022 A signalling regulator.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.885142238793134 0.129472003963518 no 2982 0.188039960357981 3946 442882
SGTC_1683 st010134 710 nM -0.887656957674474 0.128943368098323 no 2983 0.187362652718185 3954 3818134
SGTC_2074 5212007 75.395 µM -0.891528506201736 0.128132433705747 no 2984 0.1863228528238 3796 758611
SGTC_845 0330-0138 4.51 µM -0.892077627065402 0.128017702345585 no 2985 0.186175662910662 3911 9039800
SGTC_2800 7887935 81.82 µM -0.892263213324 0.127978942753878 no 2986 0.18612593346543 3989 2961002
SGTC_1027 k015-0025 8.67 µM -0.895725211104899 0.127257400691074 no 2987 0.185199771029956 3951 3598955
SGTC_2839 9003951 25.97 µM -0.89640987953778 0.127115039423726 no 2988 0.185016946357142 4019 2990634
SGTC_1411 3909-8223 150 µM -0.899991204905776 0.126372190096802 no 2989 0.184062465600866 3980 X1411
SGTC_2126 5251174 33.877 µM -0.900382077456535 0.126291297594587 no 2990 0.183958477651513 3984 790722
SGTC_275 trichlorophene 5.69 µM -0.901091550528528 0.126144561758141 no 2991 0.183769822528697 4006 62616
SGTC_72 0744-0168 198.391 µM -0.902654366383006 0.125821753763035 no 2992 0.18335468139681 3874 677577
SGTC_2955 9076254 12.21 µM -0.903018984192561 0.125746522967189 no 2993 0.183257909740709 3910 16459619
SGTC_180 1486-1293 102.781 µM -0.906941414963778 0.124939200544959 no 2994 0.182218889361411 3877 4140536
SGTC_108 0509-0257 621.132 µM -0.909162433026838 0.124483675258425 no 2995 0.18163219544946 3948 536624
SGTC_1817 st052116 64.4 µM -0.914034966104706 0.123488402425319 no 2996 0.180349236427146 3992 4361398
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.917423709217014 0.122799505862239 no 2997 0.179460326733933 4031 4174840
SGTC_101 0490-5701 117.494 µM -0.92276545180276 0.12171906542846 no 2998 0.178064724274649 3809 4661669
SGTC_1555 citronellol 128 µM -0.923682028426632 0.121534348763651 no 2999 0.177825945834541 3931 8842 A terpine precursor.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.928576588491346 0.120551289144769 no 3000 0.176554279678794 3942 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.929007898630382 0.120464930842397 no 3001 0.176442496469823 4010 77254
SGTC_608 k048-0125 159 µM -0.929923490825993 0.120281752463772 no 3002 0.176205349686712 4053 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1259 0671-0132 43 µM -0.932937350435667 0.119680169619831 no 3003 0.17542615814192 3926 X1259
SGTC_1159 4092-0538 61.2 µM -0.933383609389301 0.119591274570764 no 3004 0.175310970021436 4046 717301
SGTC_361 000s-0510 1.45 µM -0.934006839297586 0.119467204759245 no 3005 0.175150182530084 3990 660
SGTC_2949 9072542 2.23 µM -0.935266422839297 0.119216729826824 no 3006 0.174825507405659 4091 16457352
SGTC_1339 1486-1321 22.7 µM -0.935451242080671 0.119180008738332 no 3007 0.174777899841112 4020 3469382
SGTC_1796 st049173 110.4 µM -0.936899138986373 0.118892607436261 no 3008 0.174405221073777 3942 94134
SGTC_2689 tacrolimus 100 µM -0.940143323996806 0.118250428629623 no 3009 0.173572024323792 4041 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2823 7987624 58.44 µM -0.942460063840693 0.117793339015102 no 3010 0.172978574161185 4032 2239440
SGTC_199 4063-0024 41.6 µM -0.943090938471955 0.117669085188872 no 3011 0.172817195134317 4050 306215
SGTC_385 1494-0393 12.4 µM -0.945681391841663 0.117159855413209 no 3012 0.172155558173678 4016 3090647
SGTC_3318 9139014 38.6185 µM -0.949779898985655 0.116357365933434 no 3013 0.171112050810653 4019 16643984
SGTC_844 0330-0132 15.3 µM -0.949884574260739 0.116336921665424 no 3014 0.17108545287069 4071 2828079
SGTC_63 0099-0242 26.702 µM -0.95003031722293 0.116308460657213 no 3015 0.171048424054349 4070 3898502 YLR359W ADE13
SGTC_2084 5306078 60.6385 µM -0.950939749769278 0.116130976247976 no 3016 0.170817480946555 3969 679340
SGTC_1556 plumbagin 1.48 µM -0.95098470817398 0.116122207176805 no 3017 0.170806069298321 3934 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3297 9117502 71.43 µM -0.952064700393706 0.115911697501769 no 3018 0.170532084959572 4048 7453720
SGTC_1362 1611-0397 101 µM -0.953849161325509 0.115564468334705 no 3019 0.170080000215935 3993 27816
SGTC_1856 st057054 55.7 µM -0.954956416257593 0.115349385128124 no 3020 0.169799868945087 4075 1266018
SGTC_2103 5378138 10 µM -0.958831648859111 0.114598865717469 no 3021 0.168821781297309 4095 244142
SGTC_110 0850-0284 111.64 µM -0.959137200374211 0.114539837466532 no 3022 0.16874481602639 3840 3906265
SGTC_3024 9090631 49.47 µM -0.960817006045565 0.114215709172042 no 3023 0.168322093147324 4005 25236383
SGTC_2130 NSC 7 2.4545 µM -0.960998505861849 0.114180726866596 no 3024 0.168276459549004 4111 21448
SGTC_1410 3909-8106 77.9 µM -0.962435750750997 0.113903981492885 no 3025 0.167915381249338 4095 1039210
SGTC_3064 1327-0027 10 µM -0.964208557998857 0.113563281491871 no 3026 0.167470687315802 3940 16000455 YPR107C YTH1
SGTC_2221 6807166 181.081 µM -0.96544639385163 0.113325824054362 no 3027 0.167160636784922 3988 674925
SGTC_2602 kawain 100 µM -0.971114954826711 0.11224293317144 no 3028 0.165745518755971 4061 5369129
SGTC_2781 5567276 71.43 µM -0.97174677089354 0.112122694106374 no 3029 0.165588271283287 4103 2853274
SGTC_2771 fluoxetine 41.05 µM -0.972500665190027 0.111979343202259 no 3030 0.165400767059551 4056 3386 A selective serotonin reuptake inhibitor.
SGTC_1041 0206-0046 107 µM -0.973747384317461 0.111742570652141 no 3031 0.165090991832249 4071 50494
SGTC_1449 4112-4002 201 µM -0.975782116084914 0.111356911040373 no 3032 0.164586224508189 4117 2059539
SGTC_2680 butyl paraben 22.24 µM -0.982549091978569 0.110081165502031 no 3033 0.162914705091789 4136 7184 An antifungal and steroid mimetic.
SGTC_3354 9151612 71.43 µM -0.984635080393057 0.109690026604209 no 3034 0.162401675849274 4101 27261949
SGTC_2891 9063876 19.48 µM -0.98811931316736 0.109038932986457 no 3035 0.16154710910039 4069 6472478
SGTC_2673 kobusone 100 µM -0.990687830929771 0.108560739534056 no 3036 0.160919017502608 4136 6710676 An epoxy ketone and protein crosslinker.
SGTC_102 gallobenzophenone 83.616 µM -0.991966068521716 0.108323326790367 no 3037 0.160607038953733 4094 70837
SGTC_2445 5742597 35.57 µM -0.992105684402269 0.108297417964642 no 3038 0.160572986952028 4047 1774255
SGTC_2910 7948405 25.97 µM -0.992377629879257 0.10824696524899 no 3039 0.160506673597172 3999 2971328
SGTC_2463 5473429 200 µM -0.99250504855735 0.108223331705225 no 3040 0.160475608966234 4071 5399405
SGTC_3085 9117376 49.47 µM -0.99656942662167 0.107471420850187 no 3041 0.159486776111142 4177 16480349
SGTC_181 1447-1644 8.07 µM -1.00283964925466 0.10631882505395 no 3042 0.157969117521137 4104 534600
SGTC_1815 st051655 58.2 µM -1.00457392211666 0.106001611868809 no 3043 0.157551029780331 4052 5984156
SGTC_1655 st012546 55.1 µM -1.0071551460858 0.105530751462788 no 3044 0.156930111976841 4086 720985 YLR208W SEC13
SGTC_1778 st046819 58.9 µM -1.00750731849807 0.105466626502894 no 3045 0.156845521285903 4151 671715
SGTC_653 0203-0016 55.2 µM -1.01029225019316 0.104960527426912 no 3046 0.156177646499003 4144 295302
SGTC_2158 5657123 3.6195 µM -1.01061839317209 0.104901373428595 no 3047 0.156099554519275 4043 2858827
SGTC_1863 st057641 20.1 µM -1.01345580110494 0.104387758354588 no 3048 0.155421248768173 4117 3921635
SGTC_1142 3253-1408 9.78 µM -1.01963916979481 0.103274790165906 no 3049 0.15394981048956 4117 256655
SGTC_2049 5262831 67.185 µM -1.02067192724175 0.103089743018356 no 3050 0.153704949555317 4114 763417
SGTC_2492 derrusnin 100 µM -1.02178785323979 0.102890064732442 no 3051 0.153440659801027 4090 1715307 Part of coumarin class of compounds.
SGTC_607 4491-0986 66.8 µM -1.02354654344567 0.102575944039282 no 3052 0.153024752673919 4138 698981 YDR232W HEM1
SGTC_141 0443-0274 32.331 µM -1.02443925008771 0.102416764186454 no 3053 0.152813925490775 4118 1627241
SGTC_1649 st011737 51.3 µM -1.03174453483656 0.101120893107631 no 3054 0.151095904316846 4113 1761035
SGTC_1527 coumarin 137 µM -1.03415130218272 0.100696589190763 no 3055 0.150532717972663 4214 323 A hepatotoxic, DNA x-linker.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.03438920748034 0.100654718020343 no 3056 0.15047712389536 4071 16623 A steroid.
SGTC_3316 9136639 10.545 µM -1.03475620598615 0.100590151440841 no 3057 0.150391389944965 4136 4903665
SGTC_477 mead ethanolamide 10 µM -1.03552228761057 0.100455470958227 no 3058 0.150212531700495 4034 16061185
SGTC_25 0118-0223 35.662 µM -1.04025867767533 0.0996257135459077 no 3059 0.149109868364609 4113 5333628
SGTC_1925 st057770 10.1 µM -1.04149715322586 0.0994095761323935 no 3060 0.148822436867124 4123 5989122
SGTC_2153 5569715 200 µM -1.04425378086823 0.0989297234160332 no 3061 0.148183995260332 4165 2054701
SGTC_3219 9131112 49.47 µM -1.04591758245387 0.0986409227970979 no 3062 0.147799542926783 4050 17612988 YMR079W SEC14
SGTC_1871 st057448 67.3 µM -1.04618930489466 0.098593816233424 no 3063 0.147736819897677 4198 691747
SGTC_2213 7173844 200 µM -1.04625445266235 0.0985825244817482 no 3064 0.147721784167268 4090 892728
SGTC_1859 st055998 20 µM -1.04653211220093 0.0985344096945326 no 3065 0.147657713432862 4074 676301
SGTC_188 3229-0966 278.469 µM -1.0483572579688 0.0982185635417365 no 3066 0.147237019137028 4185 5722370
SGTC_130 0136-0219 337.655 µM -1.04958452923716 0.098006598505726 no 3067 0.146954586517225 3986 234244
SGTC_1801 st050089 28.441 µM -1.05220491693692 0.097555147203879 no 3068 0.146352772052325 4180 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_872 0588-0139 234 µM -1.0561412052201 0.0968798560546309 no 3069 0.145451853717204 4108 2047100
SGTC_797 k781-0471 270 µM -1.06073547573729 0.0960960326798566 no 3070 0.144405066479669 4125 23738129
SGTC_2747 doxorubicin 7.63 µM -1.0682822479666 0.09481862263637 no 3071 0.14269660682656 4143 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2596 sinensetin 100 µM -1.06895810057867 0.0947048373107363 no 3072 0.142544274886823 4180 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2594 a-mangostin 100 µM -1.07018090098338 0.094499224651052 no 3073 0.142268944732635 4206 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1066 ketoconazole 628 nM -1.07187869201492 0.0942142887823612 no 3074 0.141887260991142 4223 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_284 0988-0104 32.6 µM -1.07455202324828 0.0937669158928165 no 3075 0.141287670722267 4150 4666532
SGTC_2106 5357045 167.29 µM -1.07558078718567 0.0935951742599126 no 3076 0.141057391890745 4182 668842
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.07581367743545 0.0935563278752448 no 3077 0.141005297019102 4144 803109
SGTC_3346 9158254 43.5805 µM -1.07756597492633 0.0932644242264474 no 3078 0.140613746692986 4169 17639500
SGTC_3300 9124615 50.48 µM -1.0782551197188 0.0931498087075201 no 3079 0.140459959882836 4232 24824903
SGTC_2946 9065502 71.43 µM -1.07928890202929 0.0929780698429132 no 3080 0.140229479339121 3984 16489101
SGTC_1521 st012942 49.4 µM -1.07990553263111 0.0928757425323453 no 3081 0.140092124651944 4150 24207259
SGTC_1284 0929-0043 16 µM -1.08093757735534 0.0927046652976403 no 3082 0.139862440896025 4177 1239883
SGTC_2699 st077704 54.6 µM -1.08167109304986 0.0925832155909634 no 3083 0.139699351102112 4180 645852
SGTC_644 1498-1197 63.3 µM -1.08279081053097 0.0923980486847391 no 3084 0.139450642673057 4207 6741615
SGTC_3260 9137109 49.47 µM -1.08365217952487 0.0922557912875782 no 3085 0.139259522951624 4111 17478346
SGTC_3155 9099265 49.47 µM -1.08379545109277 0.0922321453372205 no 3086 0.139227751290955 4188 25236499
SGTC_2899 9053889 58.44 µM -1.08445387552002 0.0921235347608087 no 3087 0.139081803629131 4161 6470052
SGTC_2980 9014342 25.29 µM -1.08794588487558 0.091549091818911 no 3088 0.138309499003955 4242 2996599
SGTC_2546 rhodinyl acetate 100 µM -1.08829669404405 0.0914915300254322 no 3089 0.138232074765223 4145 6708682
SGTC_590 k048-0076 22.4 µM -1.08839387775805 0.091475588583395 no 3090 0.138210631365728 4218 6832814
SGTC_66 0109-0187 42.4 µM -1.08876660127373 0.0914144683092781 no 3091 0.138128411668509 4072 759417
SGTC_725 1497-0963 19 µM -1.09198599571935 0.090887802210571 no 3092 0.137419628343956 4300 3549977
SGTC_1306 1185-0270 9.02 µM -1.09262948127505 0.0907828038279842 no 3093 0.137278256592966 4218 1548076
SGTC_2749 bexarotene 57.39 µM -1.09385312053367 0.0905833893742286 no 3094 0.137009701010318 4217 82146 An retinoic acid receptor inhibitor.
SGTC_2983 9022671 12.99 µM -1.09446446238367 0.0904838819028206 no 3095 0.136875662649364 4188 6405161
SGTC_558 k064-0027 21.3 µM -1.09991211945211 0.0896007538552536 no 3096 0.135685206840422 4200 5088526
SGTC_2380 9035439 200 µM -1.10086362033158 0.0894471643219604 no 3097 0.135478008737684 4298 6462575
SGTC_878 0828-0289 13.7 µM -1.10100114097727 0.0894249821966748 no 3098 0.135448080289573 4135 745350 YLR208W SEC13
SGTC_3095 9117207 49.47 µM -1.10155731076614 0.0893353135624693 no 3099 0.13532708796308 4170 17015229
SGTC_1642 st009582 77.7 µM -1.10309175532486 0.0890882691631036 no 3100 0.13499366043209 4200 6739311
SGTC_1 0258-0098 57.368 µM -1.10554135901337 0.0886949391376781 no 3101 0.134462541739328 4141 6790032 YDR047W HEM12
SGTC_3003 9075612 71.4286 µM -1.10661246082437 0.0885233605283405 no 3102 0.134230758750784 4221 6501993
SGTC_50 0929-0078 56.389 µM -1.10879252366477 0.0881749027057712 no 3103 0.133759848235435 4054 1377751
SGTC_1888 azatryptophan 97.5 µM -1.10999810471942 0.0879826441068407 no 3104 0.133499921596846 4252 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3253 9135987 49.47 µM -1.11087661252208 0.0878427421344971 no 3105 0.133310731805169 4205 4182430
SGTC_2263 7948595 193.29 µM -1.1134793551488 0.0874292305823329 no 3106 0.132751305040869 4206 2971371
SGTC_602 3130-1533 38.1 µM -1.11441659670235 0.0872806823797699 no 3107 0.132550253263708 4255 720941
SGTC_1101 ebselen 5.29 µM -1.11691008050609 0.0868863950220073 no 3108 0.132016387025566 4250 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2794 7785382 27.27 µM -1.11812844812519 0.0866942227333385 no 3109 0.131756069001308 4188 2205081
SGTC_1726 st035556 14.5795 µM -1.12005746946182 0.0863906094030973 no 3110 0.131344636467612 4296 5919439
SGTC_3320 9137005 35.139 µM -1.12209886918193 0.0860701752105706 no 3111 0.130910202322098 4243 4908713
SGTC_3342 9147791 14.508 µM -1.12304363055169 0.0859221793626378 no 3112 0.130709482353063 4147 1838168
SGTC_459 nigericin 15.3 µM -1.12335701891369 0.0858731295006127 no 3113 0.130642948214505 4287 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1116 jasmonic acid 1.58368 µM -1.12521876120979 0.0855821715638888 no 3114 0.130248172448917 4275 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_939 1165-0479 45.3 µM -1.12524854430254 0.0855775229910196 no 3115 0.130241863765811 4201 1377347
SGTC_1320 1313-0481 95.3 µM -1.13278576633913 0.0844071751253799 no 3116 0.128652115099167 4203 6813365 YLR208W SEC13
SGTC_3200 9114385 49.47 µM -1.14349913618537 0.0827643718210808 no 3117 0.126415706580071 4252 17018030 YLR208W SEC13
SGTC_350 k064-0020 19.8 µM -1.14429199427307 0.0826437567418148 no 3118 0.126251281143853 4265 2790705
SGTC_456 gingerol 170 µM -1.14540923433006 0.0824740190437199 no 3119 0.126019837430139 4275 442793 A herb.
SGTC_743 1275-0778 158 µM -1.14718753389281 0.0822043908184233 no 3120 0.125652061303938 4215 2849257 YMR203W TOM40
SGTC_2960 9079389 5.97 µM -1.14790572872724 0.0820956855436084 no 3121 0.125503741507782 4243 16457355
SGTC_1545 lovastatin 49.4 µM -1.15064730697234 0.0816817185017703 no 3122 0.124938681267488 4280 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1641 st009299 47.1 µM -1.15387324059295 0.0811966333550106 no 3123 0.124276070710958 4177 4046054
SGTC_828 2074-0507 139 µM -1.15430996401544 0.081131130449323 no 3124 0.124186556459173 4309 X828
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.15761097696886 0.0806373100965667 no 3125 0.123511413830206 4271 165521
SGTC_793 0488-0545 106 µM -1.16019096042907 0.0802529364125789 no 3126 0.122985533277186 4283 292548
SGTC_1841 st054148 70 µM -1.16088303188179 0.0801500654458385 no 3127 0.122844735082803 4282 675442
SGTC_1117 retinoic acid 1.10837 µM -1.16348071444264 0.079764829506929 no 3128 0.122317259162268 4293 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1084 voriconazole 435 nM -1.16433416717224 0.0796385687384903 no 3129 0.122144307634541 4259 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3106 9121286 49.47 µM -1.16769084059929 0.0791434452264957 no 3130 0.121465746371513 4236 15943471
SGTC_2211 7117706 200 µM -1.16827872155335 0.0790569706846105 no 3131 0.121347177769152 4179 822771
SGTC_2858 9025781 8.96 µM -1.1689231346783 0.0789622627542924 no 3132 0.121217300823882 4145 4894980 YPL153C RAD53
SGTC_3067 9117431 49.47 µM -1.17049720784 0.0787312861698532 no 3133 0.120900468568269 4284 17150885
SGTC_512 prima-1 270 µM -1.1706965113763 0.0787020772915582 no 3134 0.120860393999645 4273 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_566 0958-0068 16.5 µM -1.17751893628244 0.0777071630706321 no 3135 0.119494221964434 4178 6815365
SGTC_1805 st050013 60.3 µM -1.17864098742816 0.0775444526424634 no 3136 0.119270581664268 4214 4037144
SGTC_3242 9133940 49.47 µM -1.18002147408165 0.0773446211685053 no 3137 0.118995837106443 4277 17248444
SGTC_183 3914-0051 30.55 µM -1.18528615748271 0.0765861245247271 no 3138 0.117952162340302 4301 1596232
SGTC_3244 9134489 49.47 µM -1.18687165815242 0.0763588093953517 no 3139 0.117639124074511 4282 16584271
SGTC_1044 1222-0021 1.78 µM -1.18746826847298 0.0762734057206424 no 3140 0.117521482866439 4216 4306703
SGTC_2515 chrysin 20.77 µM -1.19018544438783 0.0758853661619181 no 3141 0.116986756420583 4290 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1620 st003704 16.5 µM -1.19234478318072 0.0755780647891739 no 3142 0.116563040766976 4268 2834414
SGTC_1456 k015-0012 13 µM -1.19344010767386 0.0754225490936808 no 3143 0.116348527575784 4293 2989616
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.19654969906028 0.0749823739996121 no 3144 0.115741058154117 4265 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_919 tnp00227 403.569 nM -1.20281128951706 0.0741019695534651 no 3145 0.114524677515699 4242 1269246 A methoxyflavone. YNL221C POP1
SGTC_407 eburnamonine 100 µM -1.20370601662913 0.0739768148352226 no 3146 0.114351612981031 4133 3195
SGTC_116 0155-0182 31.788 µM -1.20464884796705 0.0738451061169415 no 3147 0.114169445361629 4178 771486
SGTC_964 1287-0107 19.4 µM -1.20506135344012 0.0737875375986136 no 3148 0.114089808821301 4300 51516812 YPR165W RHO1
SGTC_582 0987-0078 156 µM -1.20977883065736 0.0731316120670243 no 3149 0.113181885706365 4347 1625765
SGTC_618 k072-0232 33.2 µM -1.21173707781506 0.0728606483653306 no 3150 0.112806520598167 4345 5872756 YGL099W LSG1
SGTC_1261 0712-0010 12.7 µM -1.21521547137897 0.0723812372361658 no 3151 0.112141960565207 4303 2840123
SGTC_1855 st056195 39.6 µM -1.21589372376155 0.0722880390251545 no 3152 0.112012704627701 4237 4028379
SGTC_3262 9137218 49.47 µM -1.21844000106133 0.0719389772531792 no 3153 0.111528406007454 4232 17650664
SGTC_2924 9010168 62.78 µM -1.21915046875054 0.0718418122898875 no 3154 0.111393543737504 4336 2993929
SGTC_1491 4138-0063 26.5 µM -1.22145695713716 0.0715270660746259 no 3155 0.110956526575247 4293 23883227
SGTC_2820 7989630 71.43 µM -1.22296504663674 0.0713218431503648 no 3156 0.110671449226179 4342 2984098
SGTC_1523 st012844 44.7 µM -1.2240654730966 0.0711723810335888 no 3157 0.110463764794816 4379 4274103
SGTC_382 3229-0966 23.2 µM -1.23029317489151 0.070331050043012 no 3158 0.109293669599178 4347 5722370
SGTC_2491 paeonol 100 µM -1.239795874697 0.0690620484301419 no 3159 0.107525452230842 4256 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1760 st045453 10.4495 µM -1.24364586633895 0.0685529674487241 no 3160 0.106814963776276 4361 3323419 YIL048W NEO1
SGTC_2610 ononetin 44.17 µM -1.24412732664598 0.0684895085345345 no 3161 0.106726352569992 4298 259632
SGTC_945 3381-0768 11.3 µM -1.24665800427137 0.0681566972228319 no 3162 0.106261461764914 4336 1126236 YIL048W NEO1
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.24729498306948 0.0680731246300927 no 3163 0.106144678163773 4281 2333 A French combination drug.
SGTC_2351 9026858 72.31 µM -1.24887835807665 0.0678657261538644 no 3164 0.105854784179475 4227 1409300
SGTC_152 4469-0003 551.229 µM -1.25253922239292 0.0673880762919878 no 3165 0.105186722774178 4310 697280
SGTC_1291 0993-0025 5.79 µM -1.25281245677981 0.0673525306110757 no 3166 0.105136983588042 4323 4353356
SGTC_855 0428-0020 25 µM -1.25289511533033 0.0673417802287079 no 3167 0.105121939901026 4345 6812414
SGTC_2129 girgensonine 121.053 µM -1.25323986988933 0.0672969565402168 no 3168 0.105059212075356 4343 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2159 5658611 73.75 µM -1.25801176513316 0.0666788991899971 no 3169 0.104193750699019 4322 793844
SGTC_1309 pyrazolanthrone 13.4 µM -1.25994509154669 0.0664297481565548 no 3170 0.103844585365497 4305 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2520 obtusaquinone 4.71 µM -1.26085151341577 0.0663131845115141 no 3171 0.103681175038144 4376 5967872
SGTC_1715 st032160 10.2275 µM -1.26089737218145 0.0663072913980361 no 3172 0.103672912551003 4264 5289825
SGTC_3029 9088683 49.47 µM -1.26371518993568 0.0659459631981313 no 3173 0.103166135529092 4373 25236615
SGTC_349 k015-0014 24 µM -1.26413999364244 0.0658916233039307 no 3174 0.103089892027379 4344 2196908
SGTC_873 0591-4978 488 µM -1.26505190324683 0.065775091168747 no 3175 0.102926361301537 4392 3305145
SGTC_355 1311-2252 105 µM -1.26695691696632 0.0655321666213499 no 3176 0.10258534766576 4317 5338538
SGTC_353 1988-1175 58.3 µM -1.26985884034096 0.0651634554769017 no 3177 0.102067458405624 4175 2788357
SGTC_1334 1486-0610 236 µM -1.27198888098466 0.0648938437825912 no 3178 0.101688534960328 4404 3742339
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.27442318370048 0.0645867811539813 no 3179 0.101256740169029 4368 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_146 3448-8650 53.125 µM -1.27528603329796 0.0644782127402758 no 3180 0.101104009697032 4313 2891488 YIL048W NEO1
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.28180978255245 0.0636619420685104 no 3181 0.0999546908435801 4345 688662
SGTC_206 4546-0025 72.014 µM -1.28700398248399 0.0630177960267791 no 3182 0.0990464500255811 4399 6620745 YIL048W NEO1
SGTC_650 1328-0195 38 µM -1.28903392992593 0.0627674411173294 no 3183 0.0986931455065499 4356 2780821
SGTC_1607 st000305 50.6 µM -1.29617611617624 0.0618927470024259 no 3184 0.0974574080201966 4365 5457690
SGTC_670 4204-0025 119 µM -1.29642110271166 0.0618629134474552 no 3185 0.0974152228105347 4373 719039
SGTC_224 benfluorex 43.875 µM -1.29727899196226 0.0617585313280323 no 3186 0.0972676050139945 4394 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2919 7978188 46.38 µM -1.29875173267984 0.0615796589521779 no 3187 0.0970145720011219 4385 2980291
SGTC_2026 5148700 152 µM -1.30088968710608 0.0613207130072843 no 3188 0.0966481083146541 4350 79838
SGTC_897 1000-0139 31.4 µM -1.3014632765596 0.0612513856187024 no 3189 0.0965499633849749 4330 6151020
SGTC_309 k408-0051 1.48 µM -1.30359108157897 0.060994741485605 no 3190 0.0961865215420851 4277 3640463
SGTC_232 clozapine 119 µM -1.30948331775843 0.0602884383957366 no 3191 0.0951853425024589 4384 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_338 4055-0136 114 µM -1.31029696925527 0.0601914109626942 no 3192 0.0950476961778449 4355 2900563
SGTC_7 0192-1582 4.227 µM -1.3135590244327 0.059803639925953 no 3193 0.094497322781491 4427 252616
SGTC_2621 lithochol-11-enic acid 100 µM -1.31595919994885 0.0595195750944659 no 3194 0.0940938685608834 4346 6708711
SGTC_2078 5212016 200 µM -1.31614738437553 0.0594973479345258 no 3195 0.0940622897672144 4273 1899708
SGTC_383 2324-0395 7.37 µM -1.31706317713867 0.0593892731158685 no 3196 0.0939087243176423 4377 3146421
SGTC_3323 9138564 53.9225 µM -1.31922407489348 0.0591348706057855 no 3197 0.093547105979023 4388 43912313 YNL103W MET4
SGTC_2 0422-0095 29 µM -1.3268287881535 0.0582463594984401 no 3198 0.092282662577454 4280 6790840
SGTC_3238 9133470 49.47 µM -1.32808377112218 0.058100744594104 no 3199 0.092075217065884 4383 3534688
SGTC_2320 7373003 200 µM -1.33107030421361 0.0577553693217891 no 3200 0.0915829395101813 4403 5415828
SGTC_2138 5575593 77.673 µM -1.33437217437296 0.057375408249685 no 3201 0.0910409573042987 4406 762213
SGTC_3265 9137266 49.47 µM -1.335625674758 0.0572316784177206 no 3202 0.0908358269445041 4353 17224265
SGTC_2647 atorvastatin 60.16 µM -1.33793586196527 0.0569675284480381 no 3203 0.0904586727632033 4364 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_169 k015-0017 16.025 µM -1.3390987331311 0.0568349278717074 no 3204 0.0902692664330347 4383 1840002
SGTC_1191 1487-1166 10.6 µM -1.34637511490566 0.0560107234608357 no 3205 0.0890907861128183 4429 3955771
SGTC_2493 resveratrol 26.09 µM -1.34884784928982 0.0557327899915669 no 3206 0.0886929209437153 4324 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_657 3534-0529 86.7 µM -1.35676463274012 0.0548502645359602 no 3207 0.0874280042503205 4439 1049549
SGTC_2115 tiliquinol 12.7705 µM -1.36360832801204 0.0540962958650505 no 3208 0.0863454348118101 4391 71208 A bioactive hydroxyquinoline.
SGTC_2665 lovastatin 100 µM -1.36666669818504 0.0537620186701613 no 3209 0.0858649003154896 4437 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_22 0964-0034 14.468 µM -1.36740508939956 0.0536815588083665 no 3210 0.0857491839925393 4416 138402
SGTC_1120 ficusin 1.78878 µM -1.36959470846761 0.0534435244892992 no 3211 0.0854067261643964 4430 6199 A DNA cross-linker.
SGTC_2052 5265182 7.135 µM -1.37292076045706 0.053083549155573 no 3212 0.0848884909213736 4403 1239884
SGTC_3271 9137798 49.47 µM -1.37527506643611 0.0528299090154025 no 3213 0.0845230917427653 4406 6498326
SGTC_3094 9117742 49.47 µM -1.37807341430638 0.0525296817797411 no 3214 0.0840903114238995 4373 17149698
SGTC_3128 9127691 49.47 µM -1.3796500054287 0.0523611309110868 no 3215 0.0838472164927115 4440 41316314
SGTC_3313 9133968 57.047 µM -1.38040916533306 0.0522801236309412 no 3216 0.0837303498950761 4420 1494643
SGTC_1201 1889-3372 45.9 µM -1.38821039846654 0.0514534356886127 no 3217 0.0825364933998714 4322 5392199
SGTC_2669 eugenol 100 µM -1.39044580956396 0.0512184778373174 no 3218 0.0821967720248165 4448 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_202 3594-0513 34.79 µM -1.39263777546353 0.0509889161044979 no 3219 0.0818646768943961 4510 708429
SGTC_1269 0831-0796 3.05 µM -1.39463064808639 0.0507809166241235 no 3220 0.0815636240324222 4450 927758
SGTC_1763 st044482 94.5 µM -1.39502360520747 0.0507399828818453 no 3221 0.0815043607094213 4409 88505
SGTC_2265 7929201 200 µM -1.39680834887336 0.0505543994448951 no 3222 0.0812356054996162 4414 1265108
SGTC_858 0438-0351 2.77 µM -1.39946447867224 0.0502792080706129 no 3223 0.0808368715461629 4409 2799119
SGTC_1507 4075-3230 155 µM -1.40318866006777 0.0498953720450792 no 3224 0.0802802941187881 4390 659771
SGTC_109 0132-0036 33.701 µM -1.40438903608159 0.0497721534879929 no 3225 0.0801015169628046 4315 67274 A color developer.
SGTC_1844 rapamycin 4 nM -1.40459381482976 0.0497511572155 no 3226 0.0800710484584647 4287 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3218 9131285 49.47 µM -1.41532380298148 0.0486608456451085 no 3227 0.0784867895421298 4425 17156417
SGTC_360 0957-0399 1.01 µM -1.41913773740408 0.0482779314053103 no 3228 0.0779294318877779 4455 6752301 YPR165W RHO1
SGTC_3237 9133362 49.47 µM -1.4208660878431 0.0481052026919237 no 3229 0.0776778467111821 4410 43845137
SGTC_27 0485-0001 32.618 µM -1.42240570575226 0.047951752421306 no 3230 0.0774542538509476 4445 2054479
SGTC_13 0199-0087 65 µM -1.42386683117382 0.0478064879211331 no 3231 0.0772425125198977 4559 4589825
SGTC_823 0417-1665 178 µM -1.42453523129998 0.0477401534119001 no 3232 0.0771457969711979 4459 3429856
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.42663335963112 0.0475324060679034 no 3233 0.0768428016633282 4469 23847180
SGTC_179 1273-0063 6.77 µM -1.43565962511608 0.0466469115936246 no 3234 0.0755496096407927 4427 3108139
SGTC_1318 1280-3875 124 µM -1.43972216904118 0.0462527111757444 no 3235 0.0749730093545399 4458 373245
SGTC_3119 9125183 49.47 µM -1.44303917389792 0.0459328401137989 no 3236 0.0745047181455209 4314 22695334
SGTC_1430 4049-0248 69.1 µM -1.44887293178993 0.0453745830712339 no 3237 0.0736865358145451 4496 22774488
SGTC_2641 levomentholum 100 µM -1.45213708392839 0.0450646114356249 no 3238 0.0732317462147241 4468 16666
SGTC_440 fluspirilene 35.1 µM -1.46388633213789 0.0439629566731484 no 3239 0.0716125042314884 4501 3396 An atypical antipsychotic.
SGTC_1061 3448-9325 110 µM -1.47037648162174 0.0433637903179902 no 3240 0.0707299086863998 4432 723482
SGTC_3168 9103419 49.47 µM -1.47101073178232 0.043305592109196 no 3241 0.0706441073059479 4513 16649256
SGTC_212 3807-4682 38.772 µM -1.4735403253081 0.0430741060496266 no 3242 0.0703026993652906 4544 3125501 YBL034C STU1
SGTC_2207 7258803 200 µM -1.47523051456498 0.0429199926915673 no 3243 0.0700752901258626 4497 3666799
SGTC_1885 st057546 99.9 µM -1.47575456339161 0.0428722999240637 no 3244 0.070004896182722 4509 702008
SGTC_2879 9041815 71.43 µM -1.47861376215666 0.0426128430312972 no 3245 0.0696217862201377 4523 4942971
SGTC_271 rotenone 740 µM -1.49184274258645 0.0414288646183527 no 3246 0.0678701879132636 4509 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1421 4029-0249 71.4 µM -1.49346376887806 0.0412856360887261 no 3247 0.0676579157009647 4563 2894095
SGTC_3224 9130643 49.47 µM -1.50025559642323 0.0406898908188067 no 3248 0.0667741033802023 4503 17644395
SGTC_1162 k048-0130 20.1 µM -1.50780109241759 0.0400362380724523 no 3249 0.0658027212463181 4496 6797406
SGTC_3058 9093861 49.47 µM -1.51140585307392 0.0397269897169873 no 3250 0.0653425395092053 4502 17217477
SGTC_2466 5983409 37.09 µM -1.51176737148739 0.0396960829076401 no 3251 0.0652965263508326 4489 2879657
SGTC_3330 9141424 71.43 µM -1.51517858212931 0.0394054144306234 no 3252 0.0648635927363338 4516 27261020
SGTC_1103 duloxetine 36.1 µM -1.52205195793351 0.038824995258378 no 3253 0.0639980311606159 4562 60835 A selective serotonin reuptake inhibitor.
SGTC_2499 avocadenofuran 51.48 µM -1.52530200349123 0.0385529814955846 no 3254 0.0635918941486133 4473 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_705 1124-0212 310 µM -1.52765154494853 0.038357304573236 no 3255 0.0632995383452464 4502 9554485
SGTC_1043 0916-0009 19.3 µM -1.53255770045626 0.0379513154299077 no 3256 0.0626924352287664 4520 3101130
SGTC_784 4579-0127 173 µM -1.53597504893691 0.0376706033785345 no 3257 0.0622722499715363 4540 1948547
SGTC_2186 6124449 200 µM -1.55098177129284 0.0364579006412219 no 3258 0.0604530262308285 4541 3834182 YLR033W RSC58
SGTC_485 niflumic acid 177 µM -1.55962308200259 0.0357742089615147 no 3259 0.059424489300631 4562 4488 A COX2 inhibitor.
SGTC_1414 3917-0015 5.4 µM -1.56715328414992 0.0351870268748112 no 3260 0.0585394334603012 4517 6618702
SGTC_2057 5236571 38.335 µM -1.56777873288029 0.0351386140236377 no 3261 0.0584663898979772 4474 54684039 YBR257W POP4
SGTC_1508 1080-0625 72.9 µM -1.57593540326337 0.0345122364389338 no 3262 0.0575203454567169 4474 767111
SGTC_1875 nocodazole 6 µM -1.58777139584999 0.0336196511970082 no 3263 0.0561690209130337 4563 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2595 hexamethylquercetagetin 100 µM -1.60326536144984 0.032480009805249 no 3264 0.0544380402398334 4525 386331
SGTC_2761 levamisole 97.89 µM -1.61280068974835 0.0317946270785827 no 3265 0.053393908114819 4555 26879 An alkaline phosphatase inhibitor.
SGTC_2999 9069765 71.4286 µM -1.62257492295552 0.0311045175912359 no 3266 0.0523401524120253 4516 2097066
SGTC_895 0964-0006 13.7 µM -1.62553072513693 0.0308982802583974 no 3267 0.0520247612558656 4559 6738897
SGTC_159 3970-0959 50 µM -1.62687994687818 0.0308045169563858 no 3268 0.0518812988657105 4564 6615653
SGTC_2740 felodipine 17.08 µM -1.6290923299974 0.0306512786640359 no 3269 0.0516467373412493 4618 3333 L-type calcium channel blocker
SGTC_5 0352-0601 109.883 µM -1.63188903219831 0.0304584720510487 no 3270 0.0513514324673977 4465 762456
SGTC_2457 5731572 11.68 µM -1.63237885488676 0.030424806947438 no 3271 0.0512998503864401 4604 2865357
SGTC_2741 miltefosine 3.04 µM -1.63997476214578 0.02990668066736 no 3272 0.0505052072833718 4599 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1767 st044992 70.3 µM -1.64598527043512 0.0295019018375186 no 3273 0.0498833958060212 4591 9600693
SGTC_3144 9087057 49.47 µM -1.65257223816815 0.0290635350467173 no 3274 0.049208976008618 4490 17249618
SGTC_2450 5739737 12.93 µM -1.66027268256508 0.0285579414638205 no 3275 0.0484298043248889 4581 2262825
SGTC_3225 9130819 49.47 µM -1.66930395819488 0.0279743122444915 no 3276 0.0475285780950265 4540 4547121
SGTC_2767 sibutramine 71.45 µM -1.67826897382493 0.0274048238948093 no 3277 0.0466473010329108 4571 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1834 st055981 52.8 µM -1.69424101422238 0.0264141837570827 no 3278 0.0451097470555677 4570 471719 YDL150W RPC53
SGTC_1972 st070201 17.4 µM -1.69513766856889 0.0263594690894693 no 3279 0.0450246539521417 4594 2829099
SGTC_1123 mangostin 811.285 nM -1.69759840503005 0.0262097992211368 no 3280 0.0447917920365433 4585 5281650 An antioxidant.
SGTC_53 0973-0023 39.979 µM -1.70624961251323 0.0256892340719424 no 3281 0.043980807571284 4512 674768
SGTC_1153 4055-0057 267 µM -1.71216811275136 0.0253381113595823 no 3282 0.0434328459991245 4625 882706
SGTC_517 1365-0151 113 µM -1.71422387370456 0.0252170952854206 no 3283 0.0432438089725176 4585 768657
SGTC_2167 5876490 200 µM -1.77763754388939 0.0217152585350635 no 3284 0.0377317017282943 4625 686534
SGTC_3201 9113999 49.47 µM -1.7806643212364 0.0215589364219469 no 3285 0.037483652550613 4588 16649224
SGTC_1646 st011709 75.6 µM -1.78938005832848 0.0211141028257265 no 3286 0.0367768143335357 4597 5757843
SGTC_2532 xanthone 78.9 µM -1.80689826897946 0.0202434671783421 no 3287 0.0353890712510218 4632 7020 An insecticide.
SGTC_874 0599-0792 117 µM -1.81525880807004 0.0198388063491724 no 3288 0.0347420730206888 4614 765305
SGTC_2309 7664088 163.95 µM -1.82111767819559 0.019559338376066 no 3289 0.0342944852860259 4600 704922
SGTC_2164 5685496 200 µM -1.82724816695337 0.0192705008519282 no 3290 0.0338312323504255 4586 759046
SGTC_1141 3253-0389 52.6 µM -1.832885009457 0.0190081283225075 no 3291 0.0334098367477976 4630 5402031
SGTC_415 dibenzyl ketone 100 µM -1.83695169815787 0.0188207321215908 no 3292 0.0331085131462317 4625 7593
SGTC_762 1165-0429 115 µM -1.8416432268793 0.0186064978089789 no 3293 0.0327636768377833 4651 5967793
SGTC_3103 9120822 49.47 µM -1.84504077930007 0.0184526509154635 no 3294 0.0325158033899137 4631 17141819
SGTC_3254 9136651 49.47 µM -1.85486577329018 0.0180138413760848 no 3295 0.0318076983300111 4615 16454030
SGTC_1029 k015-0030 64.7 µM -1.85571661906864 0.0179762625201202 no 3296 0.0317469803589778 4650 2208316
SGTC_3039 9090270 49.47 µM -1.8604624919998 0.0177678781435076 no 3297 0.0314100601839459 4640 17173750
SGTC_1458 k015-0034 6.33 µM -1.86938131776525 0.0173818381548784 no 3298 0.0307848909419962 4667 3598957
SGTC_468 gf-109203x 121 µM -1.87299852762808 0.0172273259161161 no 3299 0.0305342941556413 4714 2396 A protein kinase C inhibitor.
SGTC_2002 4023503 131 µM -1.89116272312301 0.0164690508172448 no 3300 0.0293013128644512 4638 4736863 YCR052W RSC6
SGTC_944 3370-0224 231 µM -1.91626694490565 0.0154682141897163 no 3301 0.0276655630246561 4644 4580514
SGTC_2768 sulfasalazine 50.2 µM -1.91863425396795 0.0153765882272311 no 3302 0.0275153186904688 4642 5384001 An antioxidant and salicylic acid derivative.
SGTC_988 1497-1057 103 µM -1.93001922715249 0.0149424186855649 no 3303 0.0268022277304407 4659 3533044
SGTC_518 1021-0119 62.6 µM -1.93242778602641 0.0148519304745112 no 3304 0.0266533636198452 4632 1097762
SGTC_1283 0922-0125 16.4 µM -1.93940669086834 0.0145923930003116 no 3305 0.0262259182245125 4663 3360884
SGTC_3142 9086498 49.47 µM -1.94086767173154 0.0145385576103577 no 3306 0.0261371650777033 4546 25236367
SGTC_490 phenamil 164 µM -1.94847380380496 0.0142610340626238 no 3307 0.0256791481763978 4689 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1124 fisetin 1.16336 µM -1.95125254010588 0.0141607910351456 no 3308 0.0255135058656662 4663 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1764 st044502 93.5 µM -1.95835086425198 0.0139074707734738 no 3309 0.0250944280828971 4683 8407
SGTC_1954 st077032 68.9 µM -1.9584154318791 0.0139051845771371 no 3310 0.0250906427177777 4617 698907
SGTC_2940 9060638 45.86 µM -1.95887452329202 0.0138889385105929 no 3311 0.0250637416558015 4636 4027022
SGTC_260 nsc-65238 3.989 µM -1.96160683106535 0.0137925873302729 no 3312 0.0249041381798264 4674 3246252
SGTC_3329 9141233 27.5565 µM -1.97434731686931 0.0133508858281804 no 3313 0.0241711320416575 4640 4909101 YNL103W MET4
SGTC_1719 st032227 49.2 µM -1.97842031914527 0.0132122798888061 no 3314 0.023940654679907 4666 3125804
SGTC_2149 5554786 194.827 µM -1.98926990208472 0.0128491153799451 no 3315 0.0233357099652106 4701 745063 YPR165W RHO1
SGTC_2399 5884133 200 µM -1.99718642005595 0.0125896065663816 no 3316 0.0229024678552934 4616 722445
SGTC_548 1436-0017 110 µM -2.00912310679979 0.0122068944540167 no 3317 0.0222620398537202 4707 9677137
SGTC_2997 9067075 71.4286 µM -2.01441486910018 0.0120404825447775 no 3318 0.0219829972702154 4657 27209819
SGTC_1148 3909-7663 27.7 µM -2.03285023062748 0.0114760092731895 no 3319 0.0210338282674391 4699 4084526
SGTC_2543 pimpinellin 60.67 µM -2.0339671793129 0.0114425603471205 no 3320 0.0209774523536171 4585 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2834 9001755 58.44 µM -2.03871794692221 0.011301235011548 no 3321 0.0207390927686408 4559 2989575
SGTC_2264 7948757 110.76 µM -2.04052387589959 0.0112479117300649 no 3322 0.020649087737317 4660 2971411
SGTC_2605 digitonin 300 nM -2.04621638693135 0.0110812588357132 no 3323 0.0203675428920726 4673 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_227 fluconazole 33.516 µM -2.05522612836705 0.0108218801457445 no 3324 0.0199285842834663 4691 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_907 3448-6986 75.5 µM -2.06480007766565 0.0105520658470269 no 3325 0.0194709602603651 4693 590582
SGTC_1950 st077106 7.18 µM -2.07573250327709 0.0102511511634842 no 3326 0.0189593490136793 4630 13831864
SGTC_2742 clothiapine 36.27 µM -2.0825111832421 0.010068350607601 no 3327 0.0186479012362378 4725 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_565 1418-0001 44.5 µM -2.11153513582879 0.00931745229213268 no 3328 0.0173631705884713 4728 2862145
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.13856115847448 0.00866277254331482 no 3329 0.0162356130206754 4691 1241132 A phosphatase inhibitor.
SGTC_773 4358-1457 44.6 µM -2.17396532705628 0.00786638355510788 no 3330 0.0148538696255051 4714 1186886
SGTC_1035 k081-0041 55.2 µM -2.18022463333747 0.00773249154555033 no 3331 0.0146204072490186 4709 731709
SGTC_280 3448-3607 3.04 µM -2.2225763662548 0.00687810213111745 no 3332 0.0131221896595348 4717 626179
SGTC_31 0508-1974 57.237 µM -2.25078180429728 0.00635640620102174 no 3333 0.0121996802734044 4704 6810525
SGTC_29 0299-0004 12.984 µM -2.30016768142292 0.00552681629541945 no 3334 0.0107193610195285 4687 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2288 7946289 167.31 µM -2.41252370334478 0.00398753901972659 no 3335 0.00792125363924458 4731 1246052
SGTC_1772 st048439 82.2 µM -2.44553988871272 0.00361488386036548 no 3336 0.00723177241844207 4760 2927068 YDL195W SEC31
SGTC_2308 7584454 197.62 µM -2.45146772116539 0.00355138752819123 no 3337 0.00711374732692666 4723 893577
SGTC_321 4534-3890 65.3 µM -2.45490795179799 0.00351499819943164 no 3338 0.00704603336077509 4765 699746
SGTC_3215 9129942 49.47 µM -2.46430945689134 0.00341725476204773 no 3339 0.00686387659871961 4733 17682944
SGTC_1216 1165-0504 9.65 µM -2.46759257296666 0.0033837013233839 no 3340 0.00680125220876782 4770 6304004
SGTC_1923 st058458 19.1 µM -2.51042268072196 0.00297231271029493 no 3341 0.00602933632453826 4744 3534982
SGTC_3186 9110464 49.47 µM -2.57008346220013 0.00247432083972358 no 3342 0.00508370080140649 4771 17018021
SGTC_104 0074-0074 590.992 µM -2.57431713317514 0.00244202842300782 no 3343 0.00502190822626408 4746 3943124
SGTC_2905 7799065 20.05 µM -2.61579665478989 0.00214523124502038 no 3344 0.00445097773330604 4735 1296806
SGTC_887 0885-0007 9.62 µM -2.61752369455039 0.00213361506487996 no 3345 0.00442851694472097 4768 5719458
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -2.6513974136996 0.00191701150717085 no 3346 0.00400797299964215 4789 4213774
SGTC_2262 9014885 67.46 µM -2.66273597162727 0.00184909847669641 no 3347 0.00387541018230357 4788 6457424
SGTC_1204 4049-0315 18.3 µM -2.7037276872471 0.00162143100609245 no 3348 0.00342832273999622 4746 588402
SGTC_2287 7945887 168.79 µM -2.7595863022654 0.00135224798878417 no 3349 0.00289372992442736 4779 1245853
SGTC_2544 sphondin 68.51 µM -2.80583421157812 0.00116099491036816 no 3350 0.0025093253212437 4758 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_813 k007-0158 173 µM -2.81921281919582 0.00111048298719081 no 3351 0.00240707938990523 4779 6523916
SGTC_2252 omeprazole 400 µM -2.85192355408279 0.000995347360785319 yes 3352 0.00217277749572912 4799 4594 A proton pump inhibitor.
SGTC_1205 4161-2785 76 µM -3.08034766039321 0.00045078060469139 yes 3353 0.00103379547466689 4778 3498106
SGTC_2545 solidagenone 89.61 µM -3.14473425921975 0.00035741892301927 yes 3354 0.000831188791829126 4799 6708572 An anti ulcer agent
SGTC_1799 st045822 46.1415 µM -3.32001869130945 0.000186314019317024 yes 3355 0.000450057106884517 4797 3674992
SGTC_1717 st033143 58.0435 µM -3.58780006332156 6.5127369169405e-05 yes 3356 0.000166739924307063 4790 674616