SGTCid condition conc unit MUM3|YOR298W.score MUM3|YOR298W.strain.pval MUM3|YOR298W.strain.significant MUM3|YOR298W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1737 st035557 69.7 µM 8.10528497859886 1.69850284527273e-16 yes 1 2.63110144047542e-16 1 5716916
SGTC_1936 st074407 74.3 µM 5.04071592126447 2.04032876163776e-07 yes 2 2.31896753203218e-07 11 809813
SGTC_436 n,n-dimethylsphingosine 3.3 µM 4.95907046115884 3.13436694246821e-07 yes 3 3.5415637618977e-07 11 5282309
SGTC_3180 9109287 49.47 µM 4.27194544989506 8.9654476014067e-06 yes 4 9.68874923035459e-06 4 18891271
SGTC_2519 cryptotanshinone 88.04 µM 4.20248995529423 1.22635754630304e-05 yes 5 1.31997483181099e-05 9 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2320 7373003 200 µM 3.95322473211572 3.63128497049043e-05 yes 6 3.8552478057181e-05 27 5415828
SGTC_2268 7933382 153.85 µM 3.8689193041925 5.17102619271662e-05 yes 7 5.46594060062133e-05 40 935025 YOR257W CDC31
SGTC_1274 0865-0114 173 µM 3.66121714357812 0.000119961601219779 yes 8 0.000125509946216786 34 870624
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 3.57929815899526 0.000165275874185592 yes 9 0.000172259110777804 27 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1916 st067606 49.2 µM 3.52358565004456 0.000204763506441212 yes 10 0.000212874734300206 57 19590279
SGTC_722 3534-0461 190 µM 3.51196146794241 0.00021404353654393 yes 11 0.000222406242574011 51 658262
SGTC_2969 9091408 28.7 µM 3.41147016489132 0.000312294939622858 yes 12 0.000323067859725054 50 4286311
SGTC_1516 st013856 110 µM 3.41024859266612 0.00031371364106102 yes 13 0.000324518456867904 24 5281404 A mutagen and neurotoxin.
SGTC_65 0798-0905 34.986 µM 3.37966180652579 0.000351252008472989 yes 14 0.000362875366518513 123 3602145
SGTC_1119 parthenolide 318.541 nM 3.37155725635269 0.00036187591887961 yes 15 0.00037372250155761 69 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_453 enantio-paf c16 10 µM 3.36295827288618 0.000373473817130912 yes 16 0.00038556009278953 201 13871343 A lipid and platelet activating factor
SGTC_2883 9059145 45.46 µM 3.33654498466995 0.000411292999950607 yes 17 0.000424133498469369 22 16476510
SGTC_795 0685-0265 78 µM 3.27497778175015 0.000513654422552958 yes 18 0.000528351420496178 54 302754
SGTC_692 k241-0027 77.8 µM 3.26818573449289 0.000526287017837298 yes 19 0.000541196543462618 25 3600480
SGTC_743 1275-0778 158 µM 3.23316065261955 0.000596116839797035 yes 20 0.000612143464041547 70 2849257 YMR203W TOM40
SGTC_3149 9097855 49.47 µM 3.18763252737882 0.000699690718063979 yes 21 0.000717213533570854 58 25236625 YMR079W SEC14
SGTC_3087 9117406 49.47 µM 3.14994234900561 0.000797726748595394 yes 22 0.000816513419232755 45 42546093
SGTC_1163 k060-0048 49.9 µM 3.14463690741162 0.000812499805817918 yes 23 0.000831465406192287 55 6809982
SGTC_2274 7947094 46.08 µM 3.09462228380044 0.000964666085498851 yes 24 0.000985318407965539 72 2971028
SGTC_1094 duloxetine 25.4 µM 3.06122048418002 0.00108041884381125 no 25 0.00110218351722286 62 60834 A selective serotonin reuptake inhibitor.
SGTC_955 1216-0110 33 µM 3.0405183006077 0.00115841581943155 no 26 0.00118085669264307 120 3619719
SGTC_2736 butenafine 14.65 µM 3.00993052965891 0.00128312581879838 no 27 0.00130653724780163 72 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_664 1222-0054 14.9 µM 2.99522668441388 0.00134734256779867 no 28 0.00137120475357488 78 6813991
SGTC_1082 camptothecin 424.86 nM 2.98595895739012 0.00138931298032569 no 29 0.00141345290570799 94 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.97550423915468 0.00143808989809178 no 30 0.00146253653708414 26 4620898
SGTC_1233 0325-0408 14.2 µM 2.94435203144862 0.00159284601240991 no 31 0.00161815828537558 62 12874
SGTC_2725 haloperidol 53.21 µM 2.93436246825621 0.00164559597403231 no 32 0.00167116819434025 94 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1443 4112-3303 14 µM 2.93238401064248 0.00165623014769731 no 33 0.00168185271752753 43 704433
SGTC_2817 7995342 71.43 µM 2.91483254330041 0.00175334560989192 no 34 0.00177939719915169 68 18879975
SGTC_2508 celastrol 40.54 µM 2.8785986695491 0.00197040864196439 no 35 0.0019972315177058 53 122724 Celastrol is a natural product and antioxidant.
SGTC_1952 st077036 64.1 µM 2.87414365332551 0.00199871762483073 no 36 0.00202562324851575 87 2937007
SGTC_604 1000-0114 314 µM 2.83235539487073 0.00228279379294608 no 37 0.00231032302489238 79 1572745
SGTC_1302 1159-0335 255 µM 2.81674825981696 0.0023979442484148 no 38 0.00242562669280932 52 649284
SGTC_574 1315-0397 40 µM 2.81439730125238 0.0024157381406452 no 39 0.00244343947757379 121 6794277
SGTC_338 4055-0136 114 µM 2.81068343519153 0.00244409112142957 no 40 0.00247181998225875 64 2900563
SGTC_1707 st032323 6.317 µM 2.80108239504392 0.00251878918324847 no 41 0.00254657565643527 129 3132057 YMR211W DML1
SGTC_456 gingerol 170 µM 2.79286907625251 0.00258432192927461 no 42 0.00261214159751898 77 442793 A herb.
SGTC_136 0097-0015 404.482 µM 2.78165941612089 0.00267624830351645 no 43 0.00270408811847639 90 4861337
SGTC_77 0828-0286 12.516 µM 2.76137233472226 0.0028501533738194 no 44 0.00287795074604558 117 745345
SGTC_2557 derrustone 83.84 µM 2.75946906726711 0.002866980506988 no 45 0.00289476839123484 113 629853 An antioxidant.
SGTC_2630 antimycin a 100 µM 2.74971165185108 0.00295466275182282 no 46 0.00298238638681904 113 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2106 5357045 167.29 µM 2.72028201981103 0.00323395193009794 no 47 0.00326131302246871 71 668842
SGTC_430 0958-0115 16.4 µM 2.70674171316683 0.00337025288731713 no 48 0.0033973549248 103 6833180
SGTC_2502 avocadyne acetate 18.59 µM 2.69482412590561 0.00349446777150265 no 49 0.00352128965213964 118 3952079
SGTC_1836 st055642 81 µM 2.68997559061198 0.00354616897189292 no 50 0.00357286227806519 107 8571
SGTC_3268 9137683 49.47 µM 2.67637174518076 0.0036949167293416 no 51 0.00372120222636145 54 1953228
SGTC_130 0136-0219 337.655 µM 2.66594115810922 0.00381273258025804 no 52 0.00383865645529994 92 234244
SGTC_1731 st035964 63 µM 2.66543857582677 0.0038184934705408 no 53 0.00384439881182395 105 6739575
SGTC_2213 7173844 200 µM 2.66474712453169 0.00382643203872759 no 54 0.00385231171193561 75 892728
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.66019555062578 0.00387905897594578 no 55 0.0039047647510586 111 6708561
SGTC_3349 9149703 23.001 µM 2.6247460023734 0.00431163984165972 no 56 0.00433568135257184 78 4910494
SGTC_3072 9116419 49.47 µM 2.61916304385871 0.0043835640925718 no 57 0.00440729033008126 97 17170162
SGTC_2198 6589944 200 µM 2.5944950165081 0.00471435457716976 no 58 0.00473649934426094 61 5290268
SGTC_1703 st026983 48.3 µM 2.58958370311425 0.00478281137571291 no 59 0.00480460293039202 85 1104023
SGTC_682 0kpi-0099 17 µM 2.57655940076337 0.00496866302666254 no 60 0.0049894529034055 160 1714895 YML126C ERG13
SGTC_160 3453-0671 289.699 µM 2.57339296487541 0.00501480785370843 no 61 0.00503533956862419 131 5322268
SGTC_196 k015-0023 18.111 µM 2.55726776046971 0.0052557741608592 no 62 0.00527489882743239 95 5211998
SGTC_146 3448-8650 53.125 µM 2.55576471529069 0.00527875130767791 no 63 0.00529773675854996 276 2891488 YIL048W NEO1
SGTC_96 0929-0093 37.281 µM 2.55363207152724 0.00531150649131084 no 64 0.00533029199618002 87 6991579
SGTC_2758 dehydroepiandrosterone 69.35 µM 2.52749451914346 0.00572788427007427 no 65 0.00574398085361649 141 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3000 9075062 71.4286 µM 2.49477178333349 0.00628984482358573 no 66 0.00630190817850115 110 17057871
SGTC_2984 9022109 38.96 µM 2.48929992234821 0.00638843575676832 no 67 0.00639974692456929 72 6459207
SGTC_1806 st050005 60.3 µM 2.48202055765281 0.00652171269245627 no 68 0.0065319869116969 114 5194765
SGTC_1437 4092-1038 11.6 µM 2.48197520119023 0.00652255076974106 no 69 0.00653281839621612 109 3977136
SGTC_3078 9116413 49.47 µM 2.47110285229672 0.00672621432718128 no 70 0.0067348536125073 128 17177322
SGTC_2112 5488546 200 µM 2.46907359672774 0.00676484310936188 no 71 0.00677316774082054 118 600757
SGTC_70 0141-0289 43.283 µM 2.46696619041187 0.00680516691738935 no 72 0.00681316114510098 378 352408
SGTC_2968 9090663 33.37 µM 2.46111490892405 0.00691824263184383 no 73 0.00692529987452368 142 25236811
SGTC_1070 indatraline 8.81 µM 2.45627799544979 0.00701296497620215 no 74 0.00701922560299415 138 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_730 1436-0052 41.2 µM 2.45410227180238 0.00705594462915517 no 75 0.0070618403242098 91 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2291 7917025 104.35 µM 2.43987560795349 0.00734275377636401 no 76 0.00734616002490212 179 2964612
SGTC_2556 citropten 84.59 µM 2.43307548687658 0.00748343812771502 no 77 0.00748558966859834 161 2775 A potential DNA crosslinker.
SGTC_318 1488-0629 67.2 µM 2.43092873524411 0.00752834168329682 no 78 0.00753008820889925 104 3662576
SGTC_2993 9054257 71.4286 µM 2.42693264342584 0.00761256023701422 no 79 0.00761354130053065 184 6470217 YGL055W OLE1
SGTC_2930 9013230 14.89 µM 2.41437715020842 0.00788259223638471 no 80 0.00788106866984408 171 2995857
SGTC_1283 0922-0125 16.4 µM 2.40426486421586 0.0081061673774935 no 81 0.00810251372028026 116 3360884
SGTC_159 3970-0959 50 µM 2.39995980231882 0.00820302805458946 no 82 0.00819843617620985 281 6615653
SGTC_1615 st002656 86.5 µM 2.39011811910638 0.00842828627331223 no 83 0.00842147744202885 111 1584458
SGTC_509 pifithrin 175 µM 2.35593362625312 0.00925343587521148 no 84 0.00923810934006286 90 4817 A p53 inhibitor.
SGTC_2403 6032726 181.2 µM 2.35578973727491 0.00925705344677301 no 85 0.0092416882610562 160 2881040
SGTC_1012 4112-3522 18 µM 2.33083109032744 0.00990357863784922 no 86 0.00988113401630842 143 3112398
SGTC_1337 1486-1011 40.3 µM 2.30825207095233 0.0105220811019071 no 87 0.0104925602674321 124 X1337
SGTC_2367 9070478 135.38 µM 2.30569315130077 0.0105942569484868 no 88 0.0105638920344967 172 572802
SGTC_92 0063-0024 660.874 µM 2.30350857543857 0.0106562150796442 no 89 0.0106251226139886 133 3594437
SGTC_2347 9049783 174.81 µM 2.29594669632508 0.0108731255253803 no 90 0.0108394646597473 191 6467988 YPL169C MEX67
SGTC_1685 st024049 53.0905 µM 2.27296573103217 0.0115560789585763 no 91 0.0115141225659264 129 1941139
SGTC_43 0570-0105 72.5 µM 2.26454480100321 0.0118155008525515 no 92 0.0117703137677463 321 1114046 YDL195W SEC31
SGTC_1114 scopoletin 1.73284 µM 2.26090264525744 0.0119292602375823 no 93 0.0118826431472228 133 5280460 A coumarin with genotoxic properties.
SGTC_2265 7929201 200 µM 2.25906316451086 0.0119870749378858 no 94 0.0119397280275397 171 1265108
SGTC_3191 9110352 49.47 µM 2.25244248997363 0.0121971778699997 no 95 0.0121471615806861 130 17122424
SGTC_2589 lobaric acid 100 µM 2.2507645260431 0.0122509312331098 no 96 0.0122002277258235 174 73157 A novel microtubule depolymerizer.
SGTC_2290 7904846 200 µM 2.24302103470637 0.0125016606665678 no 97 0.0124477290520083 194 2962154
SGTC_629 3448-6466 76.7 µM 2.22518886980332 0.0130960090874998 no 98 0.0130342808612407 169 573744
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.22341163078671 0.0131565616946662 no 99 0.0130940280720905 143 688798
SGTC_1838 st055369 84.5 µM 2.21901862385561 0.0133072756647719 no 100 0.0132427287676099 153 676036
SGTC_1511 0906-3109 28.5 µM 2.20153762262629 0.0139218747293307 no 101 0.0138489931535645 253 2882180
SGTC_970 1315-0089 19.5 µM 2.19640207954451 0.0141070189489517 no 102 0.0140315884768816 155 6811083 YLR033W RSC58
SGTC_2029 5175081 200 µM 2.18925613252128 0.0143681692260113 no 103 0.0142891144163943 191 1380876
SGTC_2507 purpurin 79.67 µM 2.18347899027815 0.0145823291409244 no 104 0.0145002772554076 201 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2173 5763948 167 µM 2.16942185685296 0.0151149354544258 no 105 0.0150253355396661 158 2867177
SGTC_906 1165-0455 526 µM 2.16740644635435 0.0151926503633475 no 106 0.0151019380847578 127 3252859
SGTC_1889 st059080 5.18 µM 2.1651517750877 0.0152799978271173 no 107 0.015188032032685 183 176925 Isolated from Daphnopsis sellowiana.
SGTC_155 k072-0202 43.6 µM 2.15290805003897 0.0157618955694911 no 108 0.0156629528541739 152 5857737
SGTC_1903 st060211 78.3 µM 2.14781234174431 0.0159662653313076 no 109 0.0158643330927707 204 688960
SGTC_655 k060-0012 42 µM 2.1372007683958 0.0163991558498296 no 110 0.0162908327881373 167 5994525
SGTC_165 k038-0023 64.381 µM 2.12860160741835 0.0167572864055656 no 111 0.0166436177084297 280 46368543
SGTC_2977 9011197 71.43 µM 2.12475115915677 0.0169198026168037 no 112 0.0168036910788789 134 2704722
SGTC_475 α-linolenic acid 10 µM 2.12056291615449 0.0170981045033771 no 113 0.0169793008235225 201 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1281 0884-0031 11.8 µM 2.11458118273997 0.0173555419516874 no 114 0.017232829424862 216 1548255
SGTC_3223 9129970 49.47 µM 2.1131445079837 0.0174178632242013 no 115 0.0172942005976174 191 17248386
SGTC_2270 7924575 90.91 µM 2.08892666069661 0.0184975139874572 no 116 0.0183571627461757 186 1262135
SGTC_1697 st025554 27.742 µM 2.06695930576975 0.0195256197040404 no 117 0.0193689943312823 174 1269519
SGTC_1931 st074438 57.1 µM 2.06367663076601 0.0196833465999755 no 118 0.0195241932587235 176 2787313
SGTC_481 bay k-8644 50 µM 2.06038480821408 0.0198425979544721 no 119 0.0196808840292363 191 2303 A calcium channel antagonist.
SGTC_1254 0550-0035 264 µM 2.05112020997753 0.020296680250507 no 120 0.0201276208214185 215 15121435
SGTC_1366 1683-0113 21.9 µM 2.04227944009511 0.0207381729740066 no 121 0.0205619101674041 171 708623
SGTC_3117 9124945 49.47 µM 2.03795627210545 0.0209570083435949 no 122 0.0207771530849255 161 17592065
SGTC_1821 st053465 65.6 µM 2.02842671988268 0.0214462965139488 no 123 0.0212583576661974 170 675086
SGTC_2512 diallyl trisulfide 49.23 µM 2.02555804314511 0.0215954645076227 no 124 0.0214050473866436 143 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2571 chrysanthemic acid 100 µM 2.02017230699235 0.0218778855068544 no 125 0.0216827588658121 182 2743 An insecticide.
SGTC_2072 5231554 129 µM 2.01996272635235 0.0218889383973343 no 126 0.0216936269851073 171 789545
SGTC_3178 9107506 49.47 µM 2.01405106736493 0.0222026561481241 no 127 0.0220020860992063 198 8897194
SGTC_472 calcifediol 10 µM 2.00866043991336 0.0224920229648618 no 128 0.0222865784133495 154 5283731 A vitamin D metabolite.
SGTC_791 1348-1292 225 µM 1.99721864215255 0.0231167637000423 no 129 0.022900718399195 297 5437054
SGTC_370 0180-0345 38.7 µM 1.99070384663013 0.0234789658370313 no 130 0.0232567277905741 195 3989527
SGTC_2368 9071271 200 µM 1.98208443662952 0.0239655047172963 no 131 0.0237348955626796 245 27209959
SGTC_2020 4017018 200 µM 1.97796188203249 0.0242011888838332 no 132 0.0239665034908296 221 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_425 3825-7017 13.1 µM 1.97522596740666 0.0243586718495848 no 133 0.024121255156642 263 3397440
SGTC_1154 4088-0362 150 µM 1.97026055063304 0.0246466859270966 no 134 0.0244042585730665 286 6618304
SGTC_688 0527-0193 473 µM 1.96361979910366 0.0250363374153433 no 135 0.0247870997917866 187 4007154
SGTC_621 3584-0052 32.1 µM 1.96194169001231 0.0251356151441458 no 136 0.0248846366728243 243 2273927
SGTC_1895 st058434 18.3 µM 1.96135231621271 0.0251705609752975 no 137 0.0249189691802 219 5393175
SGTC_952 1185-0122 232 µM 1.95972995072741 0.0252669665020773 no 138 0.0250136812599341 245 678600
SGTC_476 mead acid 10 µM 1.95557293457433 0.0255154009413497 no 139 0.0252577419064624 137 5312531 An omega 9 fatty acid.
SGTC_3001 9076041 71.4286 µM 1.95481466438938 0.0255609370776436 no 140 0.025302474835786 204 16004211
SGTC_1200 1643-0193 18.4 µM 1.95168818499683 0.0257494097641306 no 141 0.0254876180960334 241 5403974
SGTC_3166 9102297 49.47 µM 1.94829632508786 0.0259551943096886 no 142 0.0256897583147128 263 25237072
SGTC_3291 9121177 71.43 µM 1.9450099423905 0.0261558900839328 no 143 0.0258868908489851 193 17015612
SGTC_3097 9117246 49.47 µM 1.93934402425893 0.026504948310571 no 144 0.0262297307881708 240 16423892
SGTC_2342 7990637 118.86 µM 1.93058160059119 0.0270524307102116 no 145 0.0267674075272522 263 2033102 YER133W GLC7
SGTC_2380 9035439 200 µM 1.92993364140697 0.0270932876969972 no 146 0.0268075302160532 267 6462575
SGTC_197 4544-0043 41.561 µM 1.92957603752495 0.0271158584081267 no 147 0.0268296951283221 298 896523
SGTC_704 1310-0270 142 µM 1.92488221101258 0.0274135737084986 no 148 0.0271220479382242 280 5718033
SGTC_458 nppb 133 µM 1.92407051815214 0.027465332372561 no 149 0.0271728724584641 199 4549 A chloride channel blocker.
SGTC_1265 0819-1001 68.8 µM 1.92150556051181 0.0276294261108925 no 150 0.0273340010138486 239 3106768
SGTC_3088 9117578 49.47 µM 1.91224715847511 0.0282285471546155 no 151 0.0279222499836732 204 678341
SGTC_1181 1222-0449 220 µM 1.91201904138671 0.0282434442963052 no 152 0.0279368758849851 237 658318
SGTC_1770 st043884 66.3 µM 1.90963588851883 0.0283994672727542 no 153 0.028090055458791 230 670149
SGTC_1175 0741-0056 27.6 µM 1.90599484534963 0.0286392276972636 no 154 0.0283254372154068 276 765927
SGTC_2904 7225135 42.03 µM 1.89449043708211 0.0294078730300549 no 155 0.0290799712497805 222 4446116
SGTC_122 0236-0016 402.397 µM 1.88883905933459 0.0297916878537607 no 156 0.0294566986244421 312 6808838
SGTC_222 nsc-310342 10.666 µM 1.8756426270001 0.0307041288987415 no 157 0.0303521844707421 134 432556
SGTC_1867 st057372 64 µM 1.87312823927324 0.0308805794536368 no 158 0.0305253393339651 237 688837
SGTC_2506 ethyl hematommate 54.16 µM 1.87063205150231 0.0310565822027745 no 159 0.0306980494281898 222 3940691 An allergen.
SGTC_3350 9150499 3.57 µM 1.86917791538497 0.0311594933579489 no 160 0.0307990328772466 329 4910996 YPR165W RHO1
SGTC_1212 0520-0165 585 µM 1.85784768683812 0.031971048000437 no 161 0.0315953235122235 274 5403258
SGTC_2674 ligustilide 100 µM 1.85342132724388 0.0322928025111471 no 162 0.0319109964001978 203 5319022 A signalling regulator.
SGTC_2766 oltipraz 83.91 µM 1.85233488105358 0.0323721840250195 no 163 0.031988874923941 249 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2359 9039622 200 µM 1.85166881010454 0.0324209302632394 no 164 0.0320366977132015 259 6463596
SGTC_2881 9058953 51.95 µM 1.84035746259829 0.0332580362203269 no 165 0.032857887097369 307 17122249
SGTC_2570 licareol 100 µM 1.83070454224156 0.0339864133576308 no 166 0.0335723273771906 289 443158
SGTC_1748 st037455 53.6035 µM 1.83019697528399 0.0340250728877361 no 167 0.0336102449679375 307 580690
SGTC_2585 alliin 100 µM 1.82775305937774 0.034211723653275 no 168 0.0337933104940358 296 87310 A garlic compound which reacts with lipids.
SGTC_3216 9129716 49.47 µM 1.82752252731566 0.0342293735857321 no 169 0.0338106211362772 251 8056934
SGTC_1150 3909-7983 10.9 µM 1.82710031943088 0.0342617179566608 no 170 0.0338423436225601 313 23965914
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.82367247190327 0.0345252484035949 no 171 0.0341008014822349 294 5393153
SGTC_1901 st060216 58.6 µM 1.82200128756744 0.03465433038451 no 172 0.0342273951422034 276 688792
SGTC_2818 7996756 12.99 µM 1.82126489017259 0.0347113352617389 no 173 0.0342833003688433 188 2241621
SGTC_2655 perillic acid 100 µM 1.81589775783034 0.0351291373172734 no 174 0.0346930286661173 183 5702197 An apoptosis inducer.
SGTC_345 1362-0200 395 µM 1.81466510616162 0.0352256729192212 no 175 0.0347876952646304 262 1419823
SGTC_523 1934-0222 13.7 µM 1.81289212602371 0.0353649060782953 no 176 0.0349242304617971 299 1361595
SGTC_167 3672-0051 66.205 µM 1.8087766622749 0.0356898360461566 no 177 0.0352428536822495 276 3237971
SGTC_648 0375-0473 33.3 µM 1.80819300255488 0.0357361154703285 no 178 0.0352882336580594 312 1713139
SGTC_3190 9110366 49.47 µM 1.80560390198941 0.0359420031996895 no 179 0.0354901163737424 220 17123768
SGTC_3185 9108267 49.47 µM 1.79649510611586 0.0366740789307354 no 180 0.0362079051705028 307 4910486
SGTC_1896 st058441 89 µM 1.78733675209043 0.0374223890656513 no 181 0.0369415386778499 257 688759
SGTC_887 0885-0007 9.62 µM 1.77404526470556 0.0385305467630774 no 182 0.0380278316931261 323 5719458
SGTC_1226 3909-7979 35.4 µM 1.76824662535186 0.0390223073399301 no 183 0.0385098413053438 350 6615510
SGTC_1386 3228-0095 33.8 µM 1.76372431286134 0.039409363966156 no 184 0.0388892028479381 269 870181
SGTC_1383 3049-0032 20.7 µM 1.75909748307228 0.0398085927384742 no 185 0.0392804761774721 306 712864
SGTC_1846 st056244 14.8 µM 1.75701760888781 0.0399891239626271 no 186 0.0394574039100687 327 5393182
SGTC_3319 9138450 16.7555 µM 1.75438479966032 0.0402186029984359 no 187 0.0396822970625067 280 2029690
SGTC_1617 st002906 78 µM 1.74043680725253 0.0414522329458043 no 188 0.0408911735897891 321 5150859
SGTC_785 1270-0111 65.3 µM 1.73095398677848 0.0423083196317692 no 189 0.0417299857713285 340 6741994
SGTC_3269 9137823 49.47 µM 1.72972465480389 0.0424203407414466 no 190 0.0418397407813771 274 17682936
SGTC_329 k048-0121 21.3 µM 1.72418304395648 0.0429282937125585 no 191 0.0423374020731201 295 6832902
SGTC_372 0155-0182 15.9 µM 1.72141614080422 0.0431837459861695 no 192 0.0425876686994853 324 771486
SGTC_947 3447-0010 211 µM 1.71197779093635 0.0440643845343161 no 193 0.043450380685119 295 748350
SGTC_1120 ficusin 1.78878 µM 1.70986594129544 0.0442633984253373 no 194 0.043645332896463 302 6199 A DNA cross-linker.
SGTC_299 1273-0059 1.44 µM 1.70592419761346 0.0446367933105264 no 195 0.0440110969221521 285 2848077
SGTC_512 prima-1 270 µM 1.70538711917999 0.0446878656854473 no 196 0.0440611245304843 325 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1258 0671-0043 57.1 µM 1.70341076520989 0.0448762083773013 no 197 0.0442456122493189 339 4298767
SGTC_1743 st037606 46.3785 µM 1.69370764468757 0.0458101868343083 no 198 0.0451604255409727 344 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1357 1503-1303 39.5 µM 1.69243291838825 0.0459340388626423 no 199 0.0452817301571872 365 292895
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.69240970170676 0.0459362970806878 no 200 0.0452839419149588 348 5106787 A p450 inhibitor.
SGTC_2729 fluphenazine 10.66 µM 1.68349184474649 0.0468103298160227 no 201 0.0461399583994416 351 3372 An atypical antipsychotic.
SGTC_2396 5342950 42.78 µM 1.6777866499962 0.0473764545885225 no 202 0.0466943782206951 387 1886677
SGTC_1905 st060207 84.5 µM 1.67654501015911 0.0475003861644185 no 203 0.0468157437878031 307 1948547
SGTC_1788 fluconazole 20 µM 1.67404419922416 0.0477507874551129 no 204 0.0470609565531229 347 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2044 5102272 200 µM 1.67380527459266 0.0477747657227468 no 205 0.0470844376946665 278 592666
SGTC_121 0557-0495 61.343 µM 1.67344168248116 0.0478112740086368 no 206 0.0471201889852703 500 3104427
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.66786197087932 0.0483743393449233 no 207 0.0476715652195608 313 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1680 diphenhydramine 100 µM 1.66569190001748 0.0485947550556745 no 208 0.0478873980641932 350 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_705 1124-0212 310 µM 1.65673911795029 0.0495125979838532 no 209 0.0487861153135896 353 9554485
SGTC_131 0141-0277 33.849 µM 1.65541075077707 0.0496499539251369 no 210 0.0489206033543056 371 1547771
SGTC_1503 4585-0012 61.3 µM 1.65514772003113 0.0496771878836434 no 211 0.0489472685112093 317 2922052
SGTC_2131 toluylene red 5.2905 µM 1.652377606305 0.0499647271993626 no 212 0.0492287988460409 363 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_746 1095-0025 46.6 µM 1.65180137322412 0.0500247069471775 no 213 0.0492875243365278 355 6749286
SGTC_2639 lactacystin 53 µM 1.63649766412166 0.051638773663083 no 214 0.050867737089162 371 3870 A proteasome inhibitor.
SGTC_1817 st052116 64.4 µM 1.6350925231655 0.0517890243853653 no 215 0.0510148266578272 334 4361398
SGTC_668 1682-0499 62.6 µM 1.62915158561593 0.0524281285006711 no 216 0.0516404665478018 422 682214
SGTC_1486 3970-0793 4.53 µM 1.62813941585363 0.052537635605573 no 217 0.0517476637381532 322 2844330
SGTC_2312 7706453 155.7 µM 1.62754812201285 0.0526016919124314 no 218 0.0518103684697701 370 976098
SGTC_3348 9149464 3.537 µM 1.62354652062929 0.0530368257553132 no 219 0.0522363135513821 345 1951442
SGTC_3275 9138069 49.47 µM 1.6187879901699 0.053557977991836 no 220 0.0527464435234835 321 17617007
SGTC_707 0865-0008 204 µM 1.61671869225522 0.0537858686448987 no 221 0.0529695085830599 344 723043
SGTC_1381 2324-0066 62.1 µM 1.61664840401935 0.0537936229140124 no 222 0.0529770985942274 382 10885928
SGTC_3233 9132340 49.47 µM 1.61065946730612 0.0544575860643551 no 223 0.053626982354627 357 17682950
SGTC_3140 9094243 49.47 µM 1.60650383629106 0.0549220971229769 no 224 0.0540816263606937 376 19291112
SGTC_24 0417-1663 219 µM 1.60208094986968 0.0554199156072538 no 225 0.0545688550041855 359 4329390
SGTC_3053 9095903 49.47 µM 1.58265399372672 0.0576488364925358 no 226 0.0567501748451784 327 17174018
SGTC_1645 Cervolide 78 µM 1.57735316525557 0.0582691028768464 no 227 0.0573571427810914 332 23173 A fragrance.
SGTC_2420 aureobasidin a 50 nM 1.57700544559477 0.0583099731514898 no 228 0.0573971360345457 437 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1238 0333-0287 48.8 µM 1.57427100630675 0.0586321589328645 no 229 0.0577124048633015 378 7226
SGTC_2008 4012253 172 µM 1.55834889067455 0.0605360259784313 no 230 0.059575282584004 434 603940
SGTC_811 0416-0114 265 µM 1.55659279000172 0.0607489375476663 no 231 0.059783598352035 383 6612453
SGTC_2137 5261020 140 µM 1.55156225874524 0.0613620870607139 no 232 0.0603834997819212 392 763655
SGTC_127 0180-0333 59.125 µM 1.54997489675521 0.061556563905253 no 233 0.060573770675992 496 771601
SGTC_2464 5717415 7.67 µM 1.54833382525526 0.0617581267160681 no 234 0.0607709722981072 407 5285744
SGTC_2786 7743617 45.45 µM 1.54427604748902 0.062258730918147 no 235 0.0612607363251065 331 583674
SGTC_2788 5282734 71.43 µM 1.54172058033482 0.0625756171080104 no 236 0.0615707542968906 453 743706
SGTC_2101 5377231 179.231 µM 1.54092439331361 0.0626746033387882 no 237 0.0616675941009234 360 2844213
SGTC_3006 9075424 71.4286 µM 1.53844885697032 0.0629831550054661 no 238 0.0619694521047649 388 7465181
SGTC_250 brefeldin a 552.239 µM 1.53491512220719 0.0634256493613516 no 239 0.0624023392258802 314 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.52429120058091 0.0647705576049312 no 240 0.0637179921557666 433 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2715 st079500 56.4 µM 1.51999364735604 0.0653208450780893 no 241 0.0642562861254863 372 28246688
SGTC_1852 st056254 31.4 µM 1.51775580355071 0.0656088260013594 no 242 0.064537985264381 390 442583
SGTC_495 decylubiquinone 155 µM 1.51630160167745 0.0657964896169602 no 243 0.0647215534216108 414 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2070 5230947 200 µM 1.51553344404114 0.0658957875545277 no 244 0.0648186837334886 406 2835538
SGTC_641 4092-0595 30 µM 1.51155748673153 0.0664116075060495 no 245 0.065323236895474 433 786260
SGTC_2671 danthron 100 µM 1.50707224435556 0.0669972459591804 no 246 0.0658960701504842 407 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_579 4491-1009 110 µM 1.50433236727035 0.067356952361159 no 247 0.0662479045064652 543 1271041
SGTC_2365 9042475 200 µM 1.50353693914829 0.067461659728943 no 248 0.0663503194123726 439 6464479
SGTC_3098 9119039 49.47 µM 1.50066244720874 0.067841096681322 no 249 0.0667214453190483 422 17161528
SGTC_1841 st054148 70 µM 1.49727520288345 0.0682903307325097 no 250 0.0671608321900255 394 675442
SGTC_883 0850-0245 24.6 µM 1.49555524050571 0.0685193181974694 no 251 0.0673847972500935 453 6823229 YPR165W RHO1
SGTC_459 nigericin 15.3 µM 1.49010553537092 0.0692487780842161 no 252 0.068098244488055 466 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1250 0485-0349 40.2 µM 1.48461309244901 0.0699899973537153 no 253 0.0688231726321735 443 6842794 YDL195W SEC31
SGTC_825 1988-2224 89.6 µM 1.4813774649798 0.0704295021275552 no 254 0.069253008160127 463 1180859
SGTC_191 3914-0123 66.505 µM 1.47905512769288 0.0707462578070379 no 255 0.0695627908345115 293 3144412
SGTC_1124 fisetin 1.16336 µM 1.47725072344444 0.0709931246913014 no 256 0.0698042207804021 410 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1076 itraconazole 331 nM 1.47270951992167 0.0716173504031006 no 257 0.0704146892505507 442 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1419 3993-2473 62.6 µM 1.47066978488044 0.0718990955333528 no 258 0.0706902206649827 438 704026
SGTC_593 1203-0218 61.7 µM 1.46221930496324 0.073075407817793 no 259 0.0718405615531313 430 3666956
SGTC_226 1,3-diallylurea 8.28947 mM 1.46140761723726 0.0731891660520514 no 260 0.0719518057651345 382 74537 YKL182W FAS1
SGTC_2849 9019321 12.99 µM 1.45851797378037 0.0735952502851021 no 261 0.072348912294452 423 16489627
SGTC_991 3996-0057 64.7 µM 1.45666983394049 0.0738558728738756 no 262 0.0726037703009561 441 715343
SGTC_1915 st067105 30.6 µM 1.45441568813661 0.0741747040506959 no 263 0.072915546530736 465 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1344 1488-0097 29.1 µM 1.4533343781713 0.0743280194445114 no 264 0.0730654683166701 441 747966
SGTC_506 n9-isopropylolomoucine 153 µM 1.44885614594134 0.0749655505540474 no 265 0.0736888801299635 435 6610355
SGTC_2212 7123476 200 µM 1.44790880900261 0.0751009484819481 no 266 0.0738212778513314 346 1085715
SGTC_2526 patulin 37.61 µM 1.44528190493797 0.0754773736790715 no 267 0.0741893592065095 538 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1724 st037281 8.293 µM 1.44479396036447 0.0755474523191731 no 268 0.0742578840244057 484 574124 YDL195W SEC31
SGTC_2208 7283366 200 µM 1.43967895603528 0.0762850563566015 no 269 0.0749791249009715 458 898663
SGTC_454 lyso-paf C-16 6.67 µM 1.43875238835021 0.0764192554419078 no 270 0.075110345218957 441 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_662 k832-1615 104 µM 1.43544749986086 0.0768993808362516 no 271 0.0755798093223577 450 5878478
SGTC_573 3702-0553 84.7 µM 1.43359155686467 0.0771700108862436 no 272 0.0758444271643884 453 1222756
SGTC_1131 3454-3128 32.3 µM 1.4247901759886 0.0784632729524594 no 273 0.077108931470463 526 710982
SGTC_1604 st002052 72.4 µM 1.42376312735817 0.0786152502329372 no 274 0.0772575264107491 468 6254834 YHR062C RPP1
SGTC_828 2074-0507 139 µM 1.4236277367677 0.078635301256585 no 275 0.0772771311432208 490 X828
SGTC_2068 5226020 147 µM 1.41877041810535 0.0793572251743059 no 276 0.0779829798439093 521 1810509
SGTC_1054 3429-0080 167 µM 1.417345609528 0.0795699375389553 no 277 0.0781909532131529 495 1162877
SGTC_2216 7189485 200 µM 1.41144144985252 0.0804559803985106 no 278 0.0790572441464192 434 731273
SGTC_1902 st060212 70.5 µM 1.41138082420235 0.0804651170535956 no 279 0.0790661770263348 481 688944
SGTC_1217 1183-1422 255 µM 1.40929248630055 0.0807803210691428 no 280 0.0793743498286794 483 2849664
SGTC_418 lividomycin a 100 µM 1.40640316288103 0.0812179582054206 no 281 0.0798022208091287 494 72394 An antibiotic.
SGTC_1558 st069300 45.6 µM 1.40576345434032 0.0813150943674354 no 282 0.0798971887163278 379 24208000
SGTC_1939 st074455 53.6 µM 1.40535798375912 0.0813767081687516 no 283 0.0799574270744487 505 1644229
SGTC_61 0978-8327 98.565 µM 1.4004891854479 0.0821193050929882 no 284 0.0806834398147256 491 6150059 YHR072W ERG7
SGTC_2939 9044578 71.43 µM 1.39935758737538 0.0822926270961198 no 285 0.0808528893084338 471 2653634
SGTC_2682 pyrogallin 40.03 µM 1.39834884570932 0.0824473638354833 no 286 0.0810041682313545 528 822798 An ATP competetive kinase inhibitor.
SGTC_708 3448-5400 146 µM 1.39667780717328 0.0827041759880201 no 287 0.0812552403991444 512 3462195
SGTC_1071 trifluoperazine 6.31 µM 1.39517254993353 0.0829360251345975 no 288 0.0814819062907916 501 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_18 0111-0177 500 nM 1.3920907594524 0.0834122264888335 no 289 0.0819474580482189 596 721752
SGTC_2835 9006588 71.43 µM 1.38740940285505 0.0841395221871337 no 290 0.0826584797067375 494 2345538
SGTC_2596 sinensetin 100 µM 1.38465951513185 0.0845689585398013 no 291 0.0830783019360574 467 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1353 1498-1206 8.11 µM 1.38426190530918 0.0846311871015578 no 292 0.0831391370359419 573 6756808
SGTC_1613 st002381 52.1 µM 1.3815699458469 0.0850534001948077 no 293 0.0835518936659824 478 551167
SGTC_3085 9117376 49.47 µM 1.37636005358189 0.0858750126979864 no 294 0.0843550944356708 485 16480349
SGTC_1927 st060202 13.8 µM 1.37303383357897 0.0864026635707459 no 295 0.0848709144202914 476 688887
SGTC_2052 5265182 7.135 µM 1.37288237423452 0.0864267477186136 no 296 0.0848944584371172 507 1239884
SGTC_190 3970-0790 3.722 µM 1.37075385794961 0.0867657426175469 no 297 0.0852258496526757 448 2832352
SGTC_1709 st033179 39.1045 µM 1.36741175100013 0.0873000215632294 no 298 0.0857481405573306 516 573381
SGTC_1441 4106-0040 13 µM 1.36669831522636 0.0874143909319466 no 299 0.0858599430851402 491 2904180
SGTC_2732 terfenadine 20 µM 1.35801181856791 0.088815887077478 no 300 0.0872299670133972 429 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1062 mesoridazine 14.2 µM 1.35625199485569 0.0891018474319334 no 301 0.0875095018681652 524 4078 A neuroleptic.
SGTC_383 2324-0395 7.37 µM 1.35561320584093 0.0892058159801579 no 302 0.0876111339338226 525 3146421
SGTC_489 paxilline 115 µM 1.35407491477251 0.0894565568190521 no 303 0.0878562391859264 462 105008 A toxic potassium channel blocker.
SGTC_2858 9025781 8.96 µM 1.35157269436902 0.0898655370045307 no 304 0.0882560251596921 643 4894980 YPL153C RAD53
SGTC_369 0957-0393 4.5 µM 1.34710650483208 0.0905989731166773 no 305 0.0889729667281946 471 6997992
SGTC_2136 5328288 199.296 µM 1.34547375322381 0.0908682092029758 no 306 0.0892361458771648 422 262395
SGTC_2472 5377652 49.4 µM 1.34512130549757 0.0909264046508697 no 307 0.0892930319796432 563 1610903
SGTC_117 lucigenin 22.078 µM 1.34340089710312 0.0912108719065165 no 308 0.0895710982846156 574 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1192 1488-0095 21.4 µM 1.3421150726581 0.0914239118211175 no 309 0.0897793437283925 493 915875
SGTC_3055 9094636 49.47 µM 1.34120609881299 0.0915747361802511 no 310 0.0899267733987862 479 25236176
SGTC_2756 carbadox 75.1 µM 1.33759298179429 0.0921760773394925 no 311 0.0905145767488293 548 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_635 k038-0028 24.7 µM 1.33090018686548 0.0932976917521453 no 312 0.0916109278807715 534 4035102
SGTC_2727 riluzole 51.77 µM 1.32784581061977 0.0938128985037712 no 313 0.0921145247855734 469 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1299 1079-1439 3.74 µM 1.32757735202971 0.0938582818284278 no 314 0.0921588852717664 509 323161
SGTC_2299 7976368 114.88 µM 1.32741807760932 0.0938852150645372 no 315 0.0921852114813513 514 2979718
SGTC_194 1486-1323 56.904 µM 1.3271799737883 0.0939254889555342 no 316 0.0922245776552915 518 5178754
SGTC_1442 4112-3290 3 µM 1.32148302513345 0.09489290055231 no 317 0.093170179419898 546 704353
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.32112278331041 0.0949543199010423 no 318 0.0932302137354782 558 165521
SGTC_1073 triclabendazole 3.09 µM 1.31757995408433 0.0955599147014631 no 319 0.0938221498654215 603 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3290 9121031 71.43 µM 1.3172804753665 0.0956112361975141 no 320 0.0938723136648789 467 17014854
SGTC_2303 7774051 200 µM 1.31630254599793 0.0957789646396824 no 321 0.0940362583363609 502 2953184
SGTC_71 0417-1750 47.813 µM 1.31449527225687 0.0960895066033144 no 322 0.0943397940236783 578 6811472
SGTC_147 4466-0538 29.23 µM 1.31417599770032 0.0961444440724398 no 323 0.0943934919186337 569 6742687 YHR072W ERG7
SGTC_1837 st055472 66.5 µM 1.31174571223066 0.0965633795262883 no 324 0.094802973755651 543 676091
SGTC_2170 morpholine 200 µM 1.31123937597045 0.0966508309140633 no 325 0.0948884515068597 521 121171 Reacts with secondary amines.
SGTC_1304 1165-0502 251 µM 1.30651652139511 0.097469337620618 no 326 0.0956884821781201 596 767425
SGTC_1408 3909-7976 48.8 µM 1.30380473620985 0.0979416024101451 no 327 0.0961500836878337 602 24152374
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.30369867894436 0.0979601065884609 no 328 0.0961681700177241 517 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2001 4023502 57.655 µM 1.30236265042833 0.0981934275670876 no 329 0.0963962220376155 562 108941 YCR052W RSC6
SGTC_2874 9043904 71.43 µM 1.30159968531277 0.098326852542856 no 330 0.0965266337302677 436 4463428
SGTC_2529 gangaleoidin 93.61 µM 1.30130923849853 0.0983776798603367 no 331 0.0965763131166939 530 4565183
SGTC_2424 5537928 59.2 µM 1.2983929074354 0.0988890958436671 no 332 0.0970761775484771 604 5382802
SGTC_1530 rhein 70.4 µM 1.29772918440619 0.0990057594155497 no 333 0.0971902056790839 583 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2625 euphol 100 µM 1.28949261036447 0.100461899288388 no 334 0.0986134418600172 603 6708538 A triterpene alcohol.
SGTC_1573 oleylamine 1.06 µM 1.28941769553344 0.100475214773721 no 335 0.0986264563851703 561 5356789 An amine of the fatty acid oleic acid.
SGTC_3057 9095946 49.47 µM 1.28908240114173 0.10053482632977 no 336 0.0986847205685018 541 24540043
SGTC_1385 3091-4834 14.1 µM 1.28820196802594 0.100691480216909 no 337 0.0988378335533022 513 4072814
SGTC_686 1319-0111 510 µM 1.28799305311122 0.100728678194182 no 338 0.0988741907050734 598 4562600
SGTC_1868 st057644 42.7 µM 1.28663345785705 0.100971003396149 no 339 0.0991110381249335 585 688665
SGTC_555 4296-0685 37 µM 1.28622519373599 0.101043852574277 no 340 0.0991822404580734 562 2908540 YHR072W ERG7
SGTC_2528 xanthyletin 44.79 µM 1.28363506215811 0.101506918989887 no 341 0.099634837812364 524 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_640 3381-0960 37.1 µM 1.28262117499845 0.10168860307647 no 342 0.0998124139578745 585 1745025
SGTC_3028 9087778 49.47 µM 1.27354496627951 0.103325574636698 no 343 0.101412363410944 527 17217395
SGTC_583 1488-1091 88.9 µM 1.27350405731528 0.103332995974544 no 344 0.101419616869077 678 4303273
SGTC_666 0272-0154 136 µM 1.27079977939848 0.103824440498786 no 345 0.101899943625714 595 6870312
SGTC_1459 k035-0031 35.7 µM 1.27045464647266 0.103887282795864 no 346 0.101961364168223 497 3877128 YMR208W ERG12
SGTC_2697 mebhydrolin 72.4 µM 1.26696908672704 0.104523485175036 no 347 0.102583171818598 633 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2147 5545932 89.7195 µM 1.26657680473648 0.10459526283991 no 348 0.102653325309416 549 797404
SGTC_188 3229-0966 278.469 µM 1.26654281524275 0.10460148373652 no 349 0.102659405439309 666 5722370
SGTC_2196 6573537 42.6665 µM 1.26630316610792 0.104645352911206 no 350 0.102702281934924 536 2903087
SGTC_3067 9117431 49.47 µM 1.26487108409825 0.104907781666106 no 351 0.102958772209446 515 17150885
SGTC_1013 4112-3890 241 µM 1.26382650278087 0.105099501287753 no 352 0.103146153211678 596 705171
SGTC_2304 7443016 91.4 µM 1.26322845557932 0.105209379331223 no 353 0.103253544634141 503 939854
SGTC_3310 9130229 44.1445 µM 1.26107447679191 0.105605814437504 no 354 0.103641007660856 563 7761258
SGTC_2867 9039098 71.43 µM 1.26080758488624 0.105655010422351 no 355 0.103689090197885 589 6463460
SGTC_2597 laccaic acid a 100 µM 1.26053274062749 0.105705689574444 no 356 0.10373862232266 591 5491415 A textile dye.
SGTC_932 2857-0803 154 µM 1.26015087835877 0.105776131186802 no 357 0.103807469602955 622 674898
SGTC_2467 5474540 200 µM 1.25925930372722 0.105940730834069 no 358 0.103968343719833 573 5413519
SGTC_2681 menadione 3.18 µM 1.2581546372111 0.106144927467115 no 359 0.104167918429504 570 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.25180791934633 0.107323623518588 no 360 0.105319931876553 535 279621
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.25064245771338 0.107541091570615 no 361 0.105532476466537 628 16486 A toxic proline analog.
SGTC_645 0845-0943 5.41 µM 1.24930714561296 0.107790642814635 no 362 0.105776377692761 572 1885106
SGTC_1805 st050013 60.3 µM 1.24818346755314 0.108000965583602 no 363 0.105981938449125 545 4037144
SGTC_1667 st014849 34.6 µM 1.24404987018054 0.108777208135847 no 364 0.106740604599082 614 5348460
SGTC_2994 9053520 71.4286 µM 1.24212716053198 0.109139634957075 no 365 0.107094824449831 594 4647384
SGTC_661 1304-0007 33.6 µM 1.24109340201237 0.109334854632132 no 366 0.107285623338307 567 3117130
SGTC_446 go6976 132 µM 1.23635511931132 0.110232863469766 no 367 0.108163295489202 554 3501 A protein kinase C inhibitor.
SGTC_2043 5101342 149 µM 1.23381285987861 0.11071685241773 no 368 0.108636323157753 593 678451
SGTC_2339 9000433 200 µM 1.23063148397114 0.111324657416344 no 369 0.109230362174764 537 2988954
SGTC_541 4513-1321 94 µM 1.23002149637034 0.111441468516397 no 370 0.109344527597013 589 747515
SGTC_2868 9035608 32.47 µM 1.22898794763925 0.111639590699128 no 371 0.109538162431406 596 6462614
SGTC_3306 9127676 59.7925 µM 1.22874912508956 0.111685406696696 no 372 0.109582940717406 568 41905287
SGTC_2728 chlorpromazine 9.18 µM 1.22843766190203 0.111745178367062 no 373 0.109641358582884 499 2726 A thorazine and dopamine antagonist.
SGTC_2260 7964312 200 µM 1.22637428678603 0.112141730482774 no 374 0.110028928851456 547 231951
SGTC_737 1950-0117 57.9 µM 1.2263201680274 0.112152144878779 no 375 0.11003910736081 585 5393513
SGTC_2473 5854593 8.94 µM 1.22236918250785 0.112914325071097 no 376 0.110784023893049 570 2872951
SGTC_1754 st042065 16.137 µM 1.22078128949703 0.113221682988333 no 377 0.111084419938614 735 1126236 YIL048W NEO1
SGTC_2382 9035899 200 µM 1.21684621007629 0.113985941416771 no 378 0.111831367247381 623 6462679
SGTC_3298 9116858 71.43 µM 1.21005564421926 0.115313413370592 no 379 0.11312877089486 641 2506942
SGTC_802 4112-3352 742 µM 1.20891836059142 0.115536808242425 no 380 0.113347105768699 669 704594
SGTC_959 1222-0044 107 µM 1.20830531803697 0.11565735471512 no 381 0.113464921822075 610 6083612
SGTC_232 clozapine 119 µM 1.2081901497408 0.115680010957768 no 382 0.113487064894214 602 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_271 rotenone 740 µM 1.20754130802375 0.115807711901554 no 383 0.113611873382015 645 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1759 st043059 70 µM 1.20576684822726 0.116157461087078 no 384 0.113953700740577 650 669426
SGTC_752 1896-0090 130 µM 1.20515879606998 0.116277481528209 no 385 0.114071002743328 620 772567
SGTC_2733 amorolfine 100 µM 1.20510732220106 0.116287645741734 no 386 0.114080936740191 501 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1194 1488-0194 225 µM 1.20399238921699 0.11650795910991 no 387 0.114296260098593 653 1391452
SGTC_424 splitomicin 100 mM 1.20266758893545 0.116770127423957 no 388 0.114552490479293 584 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2563 tomatine 8.54 µM 1.20235777996636 0.116831496650569 no 389 0.114612469747296 689 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_637 1181-0519 7.26 µM 1.20195137775527 0.116912034434531 no 390 0.114691183429348 717 6252091 YGR060W ERG25
SGTC_606 k015-0008 38.6 µM 1.20123012637847 0.117055063566393 no 391 0.114830973113274 671 1970475
SGTC_2952 9073731 13.78 µM 1.20008833402122 0.117281742305731 no 392 0.115052517895726 667 16457353
SGTC_1596 piperlongumine 63 µM 1.19994306492365 0.117310604694565 no 393 0.115080726597262 690 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2564 betulinic acid 100 µM 1.19843890255158 0.117609750776488 no 394 0.115373097572539 675 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_986 1493-0483 84 µM 1.19835915984014 0.117625624974009 no 395 0.115388612252854 615 40079
SGTC_987 1497-1013 404 µM 1.19816448532836 0.117664384750368 no 396 0.115426494203535 581 1676435
SGTC_1567 st069303 68.4 µM 1.19568237632633 0.118159366247406 no 397 0.115910265665914 647 5581319
SGTC_340 k038-0059 454 µM 1.19510846883734 0.118274024016483 no 398 0.116022326801839 629 23733424
SGTC_2005 4024620 188 µM 1.19059938190043 0.119177606722112 no 399 0.116905447198097 622 236743
SGTC_1864 st057645 30.4 µM 1.18878922022916 0.119541715010453 no 400 0.117261310509336 595 688666
SGTC_2499 avocadenofuran 51.48 µM 1.18811718290749 0.119677092734389 no 401 0.117393622783965 620 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1092 toremifene 6.32 µM 1.18746381352396 0.119808813544591 no 402 0.117522360996368 673 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1295 1013-0063 9.78 µM 1.18693313182068 0.119915875434958 no 403 0.11762699868278 651 6826038
SGTC_1156 4092-0367 4.88 µM 1.18639055943029 0.120025405910374 no 404 0.117734049089983 646 1357585
SGTC_87 0100-0052 35.5 µM 1.18603474635893 0.120097273076824 no 405 0.117804289005919 843 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_540 1187-0821 17.3 µM 1.18475954757135 0.12035508695796 no 406 0.118056265461647 603 847520
SGTC_1484 3473-2379 286 µM 1.1817009771536 0.12097504299043 no 407 0.118662185239713 746 671917
SGTC_672 1441-0018 53.7 µM 1.18084793530644 0.121148350083227 no 408 0.118831568746239 598 251141
SGTC_7 0192-1582 4.227 µM 1.18039473889348 0.121240494121659 no 409 0.118921626728799 745 252616
SGTC_2186 6124449 200 µM 1.17616579370089 0.122102700853189 no 410 0.119764315283256 623 3834182 YLR033W RSC58
SGTC_1513 0337-0559 19 µM 1.17398735410387 0.122548522254242 no 411 0.120200045456527 577 775073
SGTC_2109 5483026 200 µM 1.17377522084039 0.122591996634732 no 412 0.12024253582846 654 759335
SGTC_521 r062-0005 13.8 µM 1.17361908470886 0.122624001930562 no 413 0.120273816714103 619 2832033
SGTC_1102 cgs 12066b 26.1 µM 1.16309521182717 0.124794745395229 no 414 0.122395437297199 620 6438352 A 5-HT1B full agonist.
SGTC_3043 9092303 49.47 µM 1.16169732482809 0.125085093309772 no 415 0.122679216375514 595 25236084
SGTC_2734 clemastine 41.6 µM 1.15905448724499 0.125635311923205 no 416 0.123216987960597 505 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_16 erodoxin 22.806 µM 1.15737973000827 0.125984856475355 no 417 0.123558625917841 706 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_665 3914-0008 307 µM 1.15695175349019 0.126074289661156 no 418 0.123646036252591 644 1069549
SGTC_373 0844-0104 25.9 µM 1.15501757796435 0.126479021467001 no 419 0.124041614129516 704 5375804
SGTC_310 1273-0058 1.06 µM 1.15405360285249 0.126681073659414 no 420 0.124239096781343 851 2734232
SGTC_2384 9036245 200 µM 1.15384487646606 0.126724852950439 no 421 0.124281886004778 670 6462766
SGTC_86 0417-1630 471.922 µM 1.15105680881661 0.127310646231594 no 422 0.12485443260897 777 3634867
SGTC_1051 3253-3903 78 µM 1.14977146224101 0.127581340266919 no 423 0.125119006035302 682 5509239
SGTC_1218 1348-1416 30.7 µM 1.14519490741056 0.128548410668752 no 424 0.126064213730939 659 6787668
SGTC_1526 st051518 75 µM 1.14134468193501 0.129365931778369 no 425 0.126863257509056 618 673993
SGTC_192 3455-0609 60.9 µM 1.13846789271144 0.129979109466954 no 426 0.12746257919747 667 3769639
SGTC_1342 1486-1464 234 µM 1.13662396074358 0.130373193620165 no 427 0.127847759541395 697 3253938
SGTC_3139 9095020 49.47 µM 1.13641165383996 0.130418620740135 no 428 0.127892160363742 522 25236292
SGTC_1993 st073995 70.8 µM 1.13234439026101 0.131291003829618 no 429 0.128744837207519 685 3098394
SGTC_2215 7188065 200 µM 1.12977712805067 0.13184372322963 no 430 0.129285074052548 644 940217
SGTC_1257 0669-0121 16 µM 1.12524066944579 0.132824321112435 no 431 0.130243531804917 736 4307855
SGTC_3274 9138298 49.47 µM 1.12449805351669 0.132985321609839 no 432 0.130400897902824 704 17015756
SGTC_195 4234-0266 16.654 µM 1.12391817331348 0.133111134078462 no 433 0.130523870441221 736 2303354
SGTC_595 3909-8003 73.7 µM 1.12337822469408 0.133228356507628 no 434 0.130638446952222 682 699517
SGTC_2778 tioconazole 65.09 nM 1.12268624767738 0.133378688006932 no 435 0.130785385361203 689 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_928 2764-0428 58.7 µM 1.11776273653791 0.134451685906806 no 436 0.131834170192146 737 662578
SGTC_2091 4-phenylthiadiazole 200 µM 1.11693049742048 0.134633642580786 no 437 0.13201202180074 702 270010
SGTC_412 gemfibrozil 100 µM 1.11609868582492 0.134815674587118 no 438 0.132189947318787 653 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1128 3448-9350 235 µM 1.11246190431814 0.135613523250164 no 439 0.132969800505664 620 619386
SGTC_2496 diffractaic acid 79.83 µM 1.11037693204315 0.136072387072198 no 440 0.133418317146728 731 94870 An apoptosis inducer which activates caspases.
SGTC_888 0916-0002 6.97 µM 1.10998379828543 0.136159027487365 no 441 0.133503004065775 729 2802138 YIL048W NEO1
SGTC_1186 1319-0216 26 µM 1.10893884316011 0.136389502462866 no 442 0.133728282807464 741 4565136
SGTC_1251 0490-5699 265 µM 1.10823065387794 0.136545852112088 no 443 0.133881107704919 747 3883818
SGTC_2700 st077718 96.8 µM 1.10785277160131 0.136629328757111 no 444 0.133962702539575 646 904970
SGTC_1241 0364-0022 50.8 µM 1.10602030063293 0.137034628342613 no 445 0.134358866371163 726 4563895
SGTC_2427 5545055 42.75 µM 1.10388795590437 0.137507286169134 no 446 0.134820872039737 764 5372858
SGTC_2305 7443522 69.23 µM 1.10377566667971 0.137532207129646 no 447 0.134845231420905 750 5415886
SGTC_507 nimesulide 162 µM 1.10110378340324 0.138126102367434 no 448 0.135425745298383 717 4495 A COX2 inhibitor.
SGTC_2228 7354201 200 µM 1.10041573402009 0.138279321888999 no 449 0.13557551309333 695 753451
SGTC_90 0870-0863 4.608 µM 1.0994594334288 0.138492469778449 no 450 0.13578385956444 751 1738164
SGTC_855 0428-0020 25 µM 1.09834241700283 0.138741722643452 no 451 0.136027498257142 654 6812414
SGTC_3285 9112818 20.8695 µM 1.09527445905034 0.139427883101888 no 452 0.136698206765457 756 17017947 YPR165W RHO1
SGTC_3276 9139060 49.47 µM 1.09464623683538 0.139568671640647 no 453 0.13683582539943 663 4870619
SGTC_411 enrofloxacin 100 µM 1.09333382801408 0.139863102554214 no 454 0.137123627734507 714 71188 A bacterial gyrase inhibitor.
SGTC_2773 thioridazine 9.09 µM 1.09262876080536 0.140021454284036 no 455 0.137278414822325 728 5452 An antipsychotic.
SGTC_1325 1431-0015 227 µM 1.09261168232681 0.140025291466687 no 456 0.137282165629633 667 1103340
SGTC_1954 st077032 68.9 µM 1.09110855507108 0.140363293130673 no 457 0.137612559430668 626 698907
SGTC_868 0527-0199 213 µM 1.088669292772 0.140912977590806 no 458 0.138149873894186 738 2849450
SGTC_1122 capsaicin 818.572 nM 1.08756314433249 0.141162727252179 no 459 0.138394004269988 738 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_134 0269-0018 6.916 µM 1.08734824294482 0.141211283158563 no 460 0.13844146776005 721 4378915
SGTC_14 0354-0009 295 µM 1.08616100898379 0.141479736869708 no 461 0.138703882216019 746 1713507
SGTC_2842 9000675 19.48 µM 1.08597867633485 0.141520995984775 no 462 0.138744213214877 659 2989072
SGTC_218 alverine citrate 93.75 µM 1.0853153994166 0.14167115426651 no 463 0.138890993865862 690 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_274 sirtinol 40.1 µM 1.08283687571867 0.142233218487428 no 464 0.139440417260239 727 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2440 5628896 157.78 µM 1.08040384906857 0.142786430936477 no 465 0.139981191289548 711 5522048
SGTC_401 neomycin 50 µM 1.07984801195105 0.142913018916175 no 466 0.140104933537081 699 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_123 0083-0120 66.675 µM 1.07707082398091 0.143546639825689 no 467 0.140724313138582 724 16001701
SGTC_3158 9100007 49.47 µM 1.07530797449898 0.143949819805274 no 468 0.141118433551209 649 19297233
SGTC_176 1486-1328 72.834 µM 1.07414456293792 0.144216320774606 no 469 0.14137894717747 737 22310231
SGTC_3122 9126309 49.47 µM 1.07046160488281 0.145062162559324 no 470 0.142205791246577 721 17591206
SGTC_166 k072-0058 166.424 µM 1.0690348434453 0.145390733415444 no 471 0.142526984595004 744 5846229
SGTC_2113 5491891 107.031 µM 1.06593008907164 0.146107460363073 no 472 0.143227623051091 747 789979
SGTC_180 1486-1293 102.781 µM 1.06440604211221 0.146460150881283 no 473 0.143572398911141 747 4140536
SGTC_402 epigallocatechin gallate 10 µM 1.0639270773604 0.146571109443683 no 474 0.143680867783629 753 65064 An antioxidant.
SGTC_3167 9103034 49.47 µM 1.06361621899425 0.146643154106909 no 475 0.143751295987193 685 5127859
SGTC_578 3460-0051 92 µM 1.06075175207582 0.147308142450369 no 476 0.144401367025123 848 2876744
SGTC_566 0958-0068 16.5 µM 1.06014408583395 0.147449472111032 no 477 0.144539527015096 661 6815365
SGTC_1648 st011736 69.8 µM 1.05818271626484 0.147906262783207 no 478 0.14498607470335 722 2855514
SGTC_1291 0993-0025 5.79 µM 1.05785784461709 0.147982014707012 no 479 0.145060128231474 771 4353356
SGTC_2385 9074692 200 µM 1.05529165053121 0.148581299487352 no 480 0.145645979283566 742 17046906
SGTC_3018 9082602 49.47 µM 1.05437234861309 0.148796378803882 no 481 0.145856238428719 772 17332089
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.0527118199792 0.149185402186741 no 482 0.14623654485113 768 3256 An antibiotic and ribosome inhibitor.
SGTC_2461 5755302 26.15 µM 1.05233965427559 0.149272685079443 no 483 0.146321872236328 780 2788904
SGTC_2388 9080168 200 µM 1.04846824774642 0.150182656246922 no 484 0.147211462043273 695 15943073
SGTC_860 0443-0016 25.1 µM 1.04621789289513 0.150713296213209 no 485 0.147730221825265 782 5337942
SGTC_859 0439-0102 54.6 µM 1.04227690089048 0.151645597348034 no 486 0.148641659268146 831 610143
SGTC_2891 9063876 19.48 µM 1.04191483217628 0.151731442018795 no 487 0.148725583432167 695 6472478
SGTC_1202 1988-0068 29.6 µM 1.04119333404783 0.151902601874821 no 488 0.148892914417466 771 2850480
SGTC_1963 st076565 50.3 µM 1.0380185637959 0.15265727106518 no 489 0.149630706300348 751 4914280
SGTC_2657 nystatin 74.44 µM 1.03754362692301 0.15277038099737 no 490 0.149741287331144 787 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3210 9128157 49.47 µM 1.03708453074573 0.152879771164893 no 491 0.149848231931111 686 17590849
SGTC_1413 3910-0535 34.4 µM 1.03681628870711 0.152943710000698 no 492 0.149910741402845 800 2876951
SGTC_1892 st058411 7.36 µM 1.03473362296269 0.153440742505566 no 493 0.150396664590064 822 3934738
SGTC_1719 st032227 49.2 µM 1.03184151841953 0.154132721769491 no 494 0.151073182972588 754 3125804
SGTC_1339 1486-1321 22.7 µM 1.03160047849984 0.154190487222025 no 495 0.151129658077456 771 3469382
SGTC_2988 9073640 71.4286 µM 1.02927575325962 0.154748344838587 no 496 0.151675056871994 729 9102229
SGTC_1091 telmisartan 47.6 µM 1.02922199695481 0.154761260338655 no 497 0.151687683978362 791 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1967 st070177 51.4 µM 1.02686374987687 0.155328554147413 no 498 0.152242312890664 756 5729214
SGTC_793 0488-0545 106 µM 1.02324753845028 0.156201123013606 no 499 0.15309541064979 775 292548
SGTC_1360 1598-0022 39.8 µM 1.02083506552804 0.156785029827639 no 500 0.153666293986807 856 761525
SGTC_414 piperonyl butoxide 100 µM 1.01822814830713 0.157417611984123 no 501 0.154284772709652 761 5794 A potent inhibitor of cytochrome P450.
SGTC_3011 9081274 71.4286 µM 1.0175282994901 0.157587719205071 no 502 0.15445108840546 816 6625322
SGTC_719 2810-4230 27.3 µM 1.01708066107075 0.157696586767067 no 503 0.154557529642836 758 721079
SGTC_3263 9137018 49.47 µM 1.01641490147473 0.157858593685667 no 504 0.15471592625329 735 43844957
SGTC_273 hydroxyurea 18.1 mM 1.01586353307605 0.157992847195359 no 505 0.154847188236591 863 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_380 3970-0968 6 µM 1.01549772428155 0.158081959874485 no 506 0.154934315397812 746 2891601
SGTC_2981 9013952 38.96 µM 1.01549630002654 0.15808230689392 no 507 0.154934654685548 707 2996344
SGTC_1384 3089-0840 101 µM 1.01521780588436 0.158150171541986 no 508 0.155001007323632 747 1069836
SGTC_1674 st016616 23.6 µM 1.01346880597602 0.158576812416246 no 509 0.155418144330695 770 625830
SGTC_1001 4048-4355 44.4 µM 1.01314674846973 0.158655455463244 no 510 0.155495035824894 781 21824233
SGTC_1130 3454-2858 15.9 µM 1.01014713856286 0.159389156638343 no 511 0.156212400436043 754 715628 YIL048W NEO1
SGTC_2783 7738165 71.43 µM 1.00985814158441 0.159459962110731 no 512 0.156281629794878 672 17201110
SGTC_1616 st002734 56.1 µM 1.00978104836699 0.159478853751063 no 513 0.156300100924737 819 4026101
SGTC_2779 methotrexate 400 µM 1.00937205269922 0.159579102364055 no 514 0.156398118188596 831 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2317 5986382 200 µM 1.00920277863216 0.159620605064898 no 515 0.156438697161475 835 877883
SGTC_126 0417-1624 672.48 µM 1.00804703868744 0.159904158709776 no 516 0.156715940452371 948 41912 YDL195W SEC31
SGTC_764 1951-2361 146 µM 1.00767449618198 0.159995629881645 no 517 0.156805376242901 765 5438930
SGTC_1336 1486-0901 104 µM 1.00580997500692 0.16045394390279 no 518 0.157253494005495 794 5006114
SGTC_269 exalamide 29 µM 1.00536220357039 0.160564137264571 no 519 0.157361236351459 774 3316 A derivative of salicylamide.
SGTC_342 k048-0088 23.3 µM 1.00514880166682 0.160616671342886 no 520 0.157412601988716 785 6820570
SGTC_2653 dihydrofissinolide 100 µM 1.00481336767664 0.160699269282124 no 521 0.15749336290693 798 6857746
SGTC_1668 st014914 51.6 µM 1.00347556872623 0.161028967458631 no 522 0.157815729497833 811 2839556
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.00158740666449 0.161495052329831 no 523 0.158271452856781 848 6708784 An antioxidant flavonoid
SGTC_2677 mitomycin C 100 µM 0.999509078914428 0.162009094726865 no 524 0.158774071620111 759 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2803 7707263 71.43 µM 0.998217052390581 0.162329194233928 no 525 0.159087059656716 762 2199229
SGTC_765 1319-0117 244 µM 0.997940559311617 0.162397748822282 no 526 0.159154091421293 745 3487746 YGL099W LSG1
SGTC_3138 9097216 49.47 µM 0.997304531293041 0.162555519184654 no 527 0.15930835747172 847 25237486
SGTC_3120 9124077 49.47 µM 0.996890683553144 0.162658230005896 no 528 0.159408787151161 831 18774327 YGL155W CDC43
SGTC_1023 4482-3888 16 µM 0.994612527027429 0.163224390065738 no 529 0.159962376236762 803 3303168
SGTC_25 0118-0223 35.662 µM 0.994058626349876 0.163362236945026 no 530 0.160097163166772 807 5333628
SGTC_985 1493-0307 8.71 µM 0.992818201842724 0.163671210281809 no 531 0.160399278991412 770 3278274
SGTC_348 k064-0012 10.7 µM 0.992766109258042 0.163684194150975 no 532 0.160411974724311 769 5066323
SGTC_1994 st072947 40.9 µM 0.992212880858794 0.163822125382676 no 533 0.160546845176256 810 5286565 YDL195W SEC31
SGTC_2533 agelasine 13.65 µM 0.9906713651916 0.164206854793344 no 534 0.160923038862719 840 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_572 0960-0087 17.7 µM 0.988296472581416 0.164800723085245 no 535 0.16150373623524 884 6796365
SGTC_3308 9128332 17.569 µM 0.984004447599117 0.165877516137306 no 536 0.162556663046891 891 17332805 YDL196W YDL196W
SGTC_1691 st019933 84.6 µM 0.983764926700943 0.165937741362137 no 537 0.162615554006895 807 6176082
SGTC_2362 9071156 126 µM 0.982747069067654 0.166193829470757 no 538 0.162865969278094 813 653133
SGTC_26 0302-0163 425.158 µM 0.981445466547084 0.166521678184805 no 539 0.163186557152242 828 3100915
SGTC_6 0844-0013 19.835 µM 0.981144978477727 0.166597424642561 no 540 0.163260626320316 1022 1584900
SGTC_3154 9100113 49.47 µM 0.980862246051249 0.166668715594434 no 541 0.163330338732633 806 25237525
SGTC_1089 terbinafine 2.25 µM 0.980692899726806 0.166711425678465 no 542 0.163372103162541 824 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1701 st028638 40.4 µM 0.978816119771119 0.167185232792039 no 543 0.163835421702602 844 3490878
SGTC_827 3253-0474 693 µM 0.97660364701088 0.167744901821403 no 544 0.164382706442265 871 5402065
SGTC_1987 st072290 61.9 µM 0.975079018806678 0.168131274403578 no 545 0.164760532591612 847 54697379
SGTC_156 3474-0145 5.642 µM 0.972708431890885 0.168733166959729 no 546 0.16534911668318 827 2265471
SGTC_2893 9048488 25.97 µM 0.971896097116853 0.168939737104637 no 547 0.165551120816062 798 6467338
SGTC_3115 9123671 49.47 µM 0.968489976639007 0.169807653657561 no 548 0.166399861248978 889 3286988
SGTC_413 propylparaben 100 µM 0.968126455391678 0.169900451394255 no 549 0.166490609464854 813 7175 A pharmaceutical preservative.
SGTC_2220 6782180 200 µM 0.967683081162001 0.170013677570618 no 550 0.166601335148243 743 833803
SGTC_2187 6125751 200 µM 0.966963827374257 0.170197459014078 no 551 0.166781058440254 849 874498
SGTC_1445 4239-0156 97.7 µM 0.965542603233224 0.170560979808458 no 552 0.167136553969621 922 4008346
SGTC_557 1315-0110 16.2 µM 0.964397819039425 0.17085415399344 no 553 0.167423257627119 844 6833801
SGTC_277 nystatin 15.5 µM 0.962969086168535 0.171220498252929 no 554 0.167781518633362 869 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2100 5377183 190 µM 0.962183392918148 0.171422173324908 no 555 0.167978744855575 907 2844202
SGTC_178 4092-0806 87.505 µM 0.953569934579549 0.173643061127087 no 556 0.170150690255287 887 2169044
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.952964972982339 0.173799729032939 no 557 0.170303909064684 866 2724 A muscle relaxant with antifungal properties.
SGTC_1683 st010134 710 nM 0.95228544713661 0.173975814142069 no 558 0.170476118147933 834 3818134
SGTC_1170 0310-0127 64.8 µM 0.949787327154767 0.174624124984707 no 559 0.171110163229075 878 774975
SGTC_1633 st005664 67.9 µM 0.948659554854665 0.174917305820963 no 560 0.171396895360844 858 2063822
SGTC_2949 9072542 2.23 µM 0.948230109214527 0.175029028541511 no 561 0.17150616109401 851 16457352
SGTC_1642 st009582 77.7 µM 0.947482255140504 0.175223695064973 no 562 0.171696547108075 831 6739311
SGTC_2546 rhodinyl acetate 100 µM 0.945144279112409 0.175833155737748 no 563 0.172292611041429 890 6708682
SGTC_265 mycophenolic acid 32.932 µM 0.944690502792139 0.175951600987022 no 564 0.172408453530785 905 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3243 9134147 49.47 µM 0.940802166622396 0.1769686097153 no 565 0.173403125194193 921 24282180
SGTC_227 fluconazole 33.516 µM 0.939028677751114 0.177433703296109 no 566 0.173858010335447 886 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2067 5224629 34.075 µM 0.938681749112228 0.177524774730697 no 567 0.173947083314 826 2835000
SGTC_2663 amphotericin b 100 µM 0.938250421245373 0.177638042746389 no 568 0.174057866020347 840 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3135 9127742 49.47 µM 0.93805927548619 0.177688252786325 no 569 0.174106974439074 815 3643468
SGTC_2085 5307070 144.047 µM 0.937693596523569 0.177784334040265 no 570 0.174200947782238 810 2840351
SGTC_200 k038-0079 37.545 µM 0.937087503944021 0.177943655547242 no 571 0.174356774357067 856 3436683
SGTC_2539 epi(13)torulosol 80 µM 0.93678920167829 0.178022102306899 no 572 0.174433500463014 828 6708597
SGTC_670 4204-0025 119 µM 0.934049101748422 0.178743706488883 no 573 0.175139282600308 908 719039
SGTC_1375 2910-0797 186 µM 0.93404885593235 0.17874377130694 no 574 0.17513934599761 856 742508
SGTC_2950 9072895 21.46 µM 0.933035181979896 0.179011187958913 no 575 0.175400901811261 881 17332245
SGTC_1669 st015249 58.4 µM 0.93213867977891 0.179247903265304 no 576 0.175632430321133 958 722793
SGTC_3254 9136651 49.47 µM 0.930832152968994 0.179593235103579 no 577 0.175970197393221 931 16454030
SGTC_2065 5221596 34.26 µM 0.930131188744397 0.179778681181269 no 578 0.176151582103186 835 788581
SGTC_2710 st078562 53.7235 µM 0.929264675230507 0.180008090939682 no 579 0.176375968610759 896 17250908
SGTC_2965 9082772 38.63 µM 0.92510668875799 0.181111474872613 no 580 0.177455207064869 911 16459634
SGTC_1578 josamycin 24.2 µM 0.924256305886914 0.1813376574834 no 581 0.177676443110501 798 5282165 A P450 substrate.
SGTC_2007 4011539 71.82 µM 0.92168536691727 0.182022544159413 no 582 0.178346357758067 863 45595301
SGTC_2423 st077119 87.2 µM 0.921123523021819 0.182172431937798 no 583 0.178492970167543 864 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1298 1079-1278 263 µM 0.919730281895925 0.182544451218862 no 584 0.178856862003722 915 2840950
SGTC_2469 5655019 90.81 µM 0.919444863675515 0.18262072129747 no 585 0.178931466170377 949 2788239
SGTC_3174 9107204 49.47 µM 0.917911948974127 0.183030690464281 no 586 0.179332482713086 869 3938802
SGTC_1614 st002383 48.6 µM 0.917345584820479 0.183182306439078 no 587 0.179480788673523 882 1947235
SGTC_2199 6590217 200 µM 0.915618148679122 0.183645225621504 no 588 0.179933604523156 826 703109
SGTC_2801 7907800 81.82 µM 0.915124754878181 0.183777579251763 no 589 0.180063070310758 892 6620925
SGTC_2825 7998094 58.44 µM 0.914970372958812 0.183819004636144 no 590 0.180103591902956 847 2987815
SGTC_2821 7996764 71.43 µM 0.914196568333671 0.184026727677876 no 591 0.180306783511792 928 2987135
SGTC_950 1165-0508 94.1 µM 0.908752502064544 0.185492281360182 no 592 0.181740391881206 823 6148369
SGTC_324 1315-0088 19.6 µM 0.90777113904093 0.185757234824565 no 593 0.181999574819595 837 6787421
SGTC_3228 9131799 49.47 µM 0.907410674708542 0.185854613771356 no 594 0.18209483328172 870 17015818
SGTC_576 1073-0113 22.7 µM 0.906194351293121 0.186183435471523 no 595 0.18241649616502 1117 5439563
SGTC_1928 4'-methoxychalcone 40.3 µM 0.903945568154343 0.18679232182915 no 596 0.183012132398597 940 641818
SGTC_2236 dapsone 200 µM 0.903920363575927 0.186799153263014 no 597 0.183018815216395 970 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_619 1652-1634 108 µM 0.901943926652477 0.18733532695327 no 598 0.183543327672645 849 5400454
SGTC_2183 6420625 130.508 µM 0.901880308018192 0.187352601396322 no 599 0.183560226515549 942 2897619
SGTC_3332 9141069 11.198 µM 0.901034068149393 0.187582475566236 no 600 0.183785103109972 848 17332883
SGTC_1148 3909-7663 27.7 µM 0.900545706813647 0.187715214217991 no 601 0.183914956471843 946 4084526
SGTC_1774 st048371 48.465 µM 0.900489398090677 0.187730522893974 no 602 0.183929932413082 932 4242727
SGTC_2471 5466956 24.79 µM 0.897945331649658 0.18842298361829 no 603 0.18460734770964 892 724419
SGTC_263 alizarin 107.927 µM 0.897240629646537 0.188615072313703 no 604 0.184795264621353 964 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.897095767409579 0.188654574027239 no 605 0.18483390853462 910 97141
SGTC_539 4859-0462 2.54 µM 0.895514924370613 0.189085977143047 no 606 0.185255945692697 938 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1773 st048542 73.5835 µM 0.894317870815411 0.189413050165588 no 607 0.185575920485855 880 3237138
SGTC_2669 eugenol 100 µM 0.894187849167915 0.189448597158458 no 608 0.185610696167307 875 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_522 1273-0010 11.6 µM 0.892997844717524 0.189774126606526 no 609 0.185929163432847 898 5705015
SGTC_2848 9016370 25.97 µM 0.89226828705352 0.189973869377197 no 610 0.186124574031296 958 7894410
SGTC_1652 st011932 78 µM 0.890635114693217 0.190421477549348 no 611 0.186562477288554 906 1551076
SGTC_2061 5245884 80.95 µM 0.890495776287329 0.190459696383074 no 612 0.186599867674435 926 573863
SGTC_2389 9091542 195.52 µM 0.889213171906267 0.190811720393005 no 613 0.186944262560103 910 3626624 YOL127W RPL25
SGTC_2777 climbazole 1.536 µM 0.888876770874359 0.190904115172456 no 614 0.187034655392882 937 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1473 k844-0725 134 µM 0.887957362134835 0.191156776872972 no 615 0.187281843547532 1031 54682906
SGTC_872 0588-0139 234 µM 0.887100759792286 0.191392363221496 no 616 0.187512327523896 955 2047100
SGTC_2730 imipramine 71.33 µM 0.887098488762483 0.191392988045973 no 617 0.18751293881743 1019 3696 A tricyclic antidepressant.
SGTC_1636 st007707 68.9 µM 0.884336269374954 0.192153877792027 no 618 0.18825735742559 949 403051
SGTC_2345 9052315 157.45 µM 0.883944469829126 0.192261953811276 no 619 0.188363094936957 898 6469265
SGTC_700 3453-2283 142 µM 0.882252991330788 0.19272896661403 no 620 0.188820005667175 982 565664
SGTC_1127 asiatic acid 681.4 nM 0.880804162062914 0.193129535213745 no 621 0.189211913322684 872 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1908 st060353 56.5 µM 0.880523030523363 0.193207320579419 no 622 0.18928801725627 986 4227716
SGTC_1992 st073643 23.3 µM 0.88027591225458 0.193275710714384 no 623 0.189354929160678 916 3161292
SGTC_287 k060-0039 29.6 µM 0.879698121641481 0.19343567227215 no 624 0.189511433608572 963 5861974
SGTC_1331 1472-0049 76.2 µM 0.877823386296546 0.19395524942578 no 625 0.190019785537476 893 24051409
SGTC_17 0960-0276 49.807 µM 0.877711955275949 0.193986158945323 no 626 0.190050027461512 993 6821114
SGTC_1008 4106-0037 6 µM 0.876660404641773 0.1942779932366 no 627 0.190335559661486 941 2905394
SGTC_2239 6685329 187.64 µM 0.876658281195261 0.194278582821901 no 628 0.19033613651677 906 805680
SGTC_63 0099-0242 26.702 µM 0.876335848947147 0.194368120354253 no 629 0.190423740892158 992 3898502 YLR359W ADE13
SGTC_2036 5160441 105 µM 0.876184674157537 0.194410109350785 no 630 0.190464823388788 989 134534 YIL048W NEO1
SGTC_2025 5147754 141 µM 0.875681804132213 0.194549821891711 no 631 0.190601519962944 943 315777 YLR208W SEC13
SGTC_2293 7624732 200 µM 0.875009232605021 0.194736778141751 no 632 0.190784441086312 907 894453
SGTC_2926 9010726 65.15 µM 0.871755758322738 0.195642695935796 no 633 0.191670817392064 928 2994293
SGTC_2957 9076800 11.52 µM 0.870136466325438 0.196094533807817 no 634 0.192112915653858 864 16459615
SGTC_1428 4049-0204 61.7 µM 0.869516874969255 0.196267588276649 no 635 0.192282241069911 992 X1428
SGTC_3227 9130768 49.47 µM 0.869432488086637 0.196291165049545 no 636 0.192305309853091 973 17720899
SGTC_1471 k673-0312 37 µM 0.868796805264898 0.196468823060564 no 637 0.192479140417865 963 24099884
SGTC_2323 6148992 148.28 µM 0.868526546917344 0.196544383258354 no 638 0.19255307297271 845 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3316 9136639 10.545 µM 0.866215728567905 0.197191172201266 no 639 0.193185934771526 951 4903665
SGTC_680 0417-1641 114 µM 0.864825444203067 0.197580927032353 no 640 0.193567301741778 885 2835990
SGTC_1564 D-Arginine 115 µM 0.86365550188019 0.197909271333918 no 641 0.193888582502431 931 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1960 st011366 51.8 µM 0.863519058387027 0.197947585648903 no 642 0.193926072738621 1000 3972846
SGTC_438 sphingosine 6.67 µM 0.863449557064048 0.197967103842845 no 643 0.193945171140875 903 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2754 granisetron 64.02 µM 0.863389123343239 0.197984076508917 no 644 0.193961778770885 946 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1768 st044301 37.178 µM 0.862989730701237 0.198096267072891 no 645 0.194071556587021 997 3931349
SGTC_1783 st039459 87.517 µM 0.862900712453196 0.198121277790136 no 646 0.194096029468396 1016 729761
SGTC_511 blebbistatin 171 µM 0.862773096943529 0.198157136184776 no 647 0.194131116781574 952 3476986 A myosin inhibitor.
SGTC_3197 9113331 49.47 µM 0.862643101912636 0.198193667223965 no 648 0.194166862305629 945 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1382 3002-2117 298 µM 0.861611281460085 0.198483772282274 no 649 0.19445073042415 1027 1497314
SGTC_913 3487-1245 167 µM 0.861183858748568 0.198604020798891 no 650 0.194568394300965 917 4016153
SGTC_1460 k062-0059 9.15 µM 0.860635224580951 0.198758434591512 no 651 0.194719489591681 938 1373085
SGTC_3037 9091026 49.47 µM 0.860381387424465 0.198829901871579 no 652 0.194789421157939 1025 25236398 YIL048W NEO1
SGTC_1722 st034304 3.6505 µM 0.857287654310592 0.199702179830338 no 653 0.195642964876146 946 4036148 YLR033W RSC58
SGTC_734 2023-0417 80 µM 0.85717127812508 0.199735036961383 no 654 0.195675116668868 945 3935732
SGTC_912 3474-0017 2.18 µM 0.855857901612601 0.200106075220886 no 655 0.19603819166612 980 3360550
SGTC_2360 9040895 200 µM 0.854392256466161 0.200520619234879 no 656 0.196443842506226 903 4914414
SGTC_2151 5563267 85.4165 µM 0.854158771078306 0.200586705982571 no 657 0.196508511873781 971 5310824
SGTC_1635 st007035 42.4 µM 0.853694719530321 0.200718092026952 no 658 0.196637080351386 1030 3716403
SGTC_3347 9188721 44.724 µM 0.852348657173595 0.201099492277044 no 659 0.197010303794093 925 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1979 st071809 45.3 µM 0.851715475349319 0.20127905149821 no 660 0.197186014647258 981 4976333
SGTC_1771 st048882 4.1505 µM 0.851556522654229 0.201324142773509 no 661 0.197230139632108 974 4580403
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.85048824278574 0.201627346619785 no 662 0.197526847172175 1025 688664
SGTC_1362 1611-0397 101 µM 0.848539975672015 0.202181016122796 no 663 0.19806865962238 983 27816
SGTC_857 0438-0306 1.35 µM 0.845226982685298 0.203124606983968 no 664 0.198992059898608 986 4686136
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.84409838951982 0.20344664689903 no 665 0.199307213793491 909 6857784
SGTC_3172 9105863 49.47 µM 0.842742133037051 0.203834052386552 no 666 0.199686338872082 962 2348785
SGTC_2255 7941087 197.44 µM 0.841173749593348 0.20428259830229 no 667 0.20012530206374 1049 935561
SGTC_2166 5933061 31.504 µM 0.840325351894041 0.204525478438142 no 668 0.200362995334783 1067 2877375
SGTC_298 1391-0729 10 µM 0.839798628627525 0.204676355723675 no 669 0.200510651252877 974 3237558
SGTC_1738 st035555 74 µM 0.838763126326838 0.204973163222681 no 670 0.200801123245464 986 5331140
SGTC_1717 st033143 58.0435 µM 0.838387008970822 0.205081033592202 no 671 0.200906691594865 1001 674616
SGTC_2911 7942208 15.64 µM 0.838385990192062 0.205081325823523 no 672 0.200906977590171 941 1243384
SGTC_1632 st005650 90 µM 0.838036419762902 0.205181612870856 no 673 0.201005124703416 946 2759605
SGTC_1439 4092-1168 46 µM 0.837710108960615 0.205275253336022 no 674 0.201096767279706 1002 2886240
SGTC_270 tamoxifen 5.46 µM 0.836803361022395 0.205535593421588 no 675 0.201351553932882 1050 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2266 7929956 200 µM 0.836365348964953 0.205661423030553 no 676 0.201474700002825 1008 2967153
SGTC_2811 7967822 32.47 µM 0.835291971237133 0.205969970118607 no 677 0.201776668406449 965 2232244
SGTC_88 0180-0332 8.668 µM 0.832903059452103 0.206657657926711 no 678 0.202449702025933 1061 3101745
SGTC_2702 st077768 96.8 µM 0.830595848996146 0.207323115638228 no 679 0.203100990260009 898 6484119
SGTC_1661 st013063 9.66 µM 0.829337451576433 0.207686602563839 no 680 0.203456742106461 1064 721395
SGTC_845 0330-0138 4.51 µM 0.829280677504737 0.207703010572904 no 681 0.203472801026193 1011 9039800
SGTC_762 1165-0429 115 µM 0.829276976247533 0.207704080282536 no 682 0.203473847977399 995 5967793
SGTC_2755 lomerizine 42.69 µM 0.828904527028926 0.207811739406472 no 683 0.203579216761941 1016 3949 A calcium channel blocker.
SGTC_3092 9117248 49.47 µM 0.826948182250127 0.208377775905215 no 684 0.204133216101505 1060 17141857
SGTC_1611 st001856 99.4 µM 0.82649807753849 0.20850813493797 no 685 0.204260804078921 960 647478
SGTC_1482 3346-2049 8.48 µM 0.825022550856311 0.208935813078986 no 686 0.20467939397294 994 3826804
SGTC_2390 9097792 176.6 µM 0.824856160669394 0.208984073306181 no 687 0.204726628944914 951 4497149
SGTC_3318 9139014 38.6185 µM 0.824135769886668 0.209193092992246 no 688 0.204931208818692 968 16643984
SGTC_3134 9127454 49.47 µM 0.82394084610006 0.209249670817975 no 689 0.204986585054436 1030 24262820
SGTC_2103 5378138 10 µM 0.823550178925202 0.209363091476533 no 690 0.20509759714422 1077 244142
SGTC_62 0180-0423 3.232 µM 0.822816683344145 0.209576141682026 no 691 0.205306123940441 1005 30102 YGL099W LSG1
SGTC_766 1391-0721 126 µM 0.822232225379277 0.209745993859129 no 692 0.2054723706829 1013 1020919 YIL115C NUP159
SGTC_2628 lathosterol 100 µM 0.821108696424204 0.210072735329785 no 693 0.205792178466814 1032 6710616
SGTC_993 3909-8757 62.7 µM 0.820302304698412 0.21030743208786 no 694 0.206021896435919 925 4288324 YLR208W SEC13
SGTC_199 4063-0024 41.6 µM 0.819880896684374 0.210430142261203 no 695 0.206142004018956 1042 306215
SGTC_177 1327-0068 8.361 µM 0.817271743724999 0.211190839008371 no 696 0.206886575372344 997 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_254 nsc-64875 3.808 µM 0.816464373325207 0.211426553341802 no 697 0.207117295934781 1041 56993
SGTC_2942 9052777 62.25 µM 0.815670881127423 0.211658365945339 no 698 0.20734419879088 1071 6469503
SGTC_1204 4049-0315 18.3 µM 0.815255937245255 0.211779647804069 no 699 0.207462912461671 968 588402
SGTC_531 3788-1495 174 µM 0.8131723319435 0.212389268791798 no 700 0.208059630120191 954 2896655
SGTC_853 0419-0306 21 µM 0.812070691153686 0.212712000673732 no 701 0.208375534813178 947 762713
SGTC_724 3910-0327 137 µM 0.812060341110198 0.212715034134398 no 702 0.208378504115412 1040 2885483
SGTC_1762 st045503 25.4615 µM 0.811862171036972 0.212773120029616 no 703 0.20843536152476 1063 4645554
SGTC_1309 pyrazolanthrone 13.4 µM 0.810818870833788 0.213079075809085 no 704 0.208734847913846 1068 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_758 0868-0029 16 µM 0.810638936075634 0.213131868992388 no 705 0.208786525033278 1065 762687
SGTC_2013 4024628 200 µM 0.810161829606053 0.21327188982323 no 706 0.208923586124249 982 5230760
SGTC_2439 5492030 7.2 µM 0.809525372891129 0.213458760116222 no 707 0.209106507156618 997 5722370
SGTC_1187 1391-0724 117 µM 0.807671512039582 0.214003616413037 no 708 0.209639853699337 1036 6997986
SGTC_2889 9059656 51.95 µM 0.805784861421915 0.214558939988679 no 709 0.210183454202196 1068 3949838
SGTC_3188 9110789 49.47 µM 0.805722128412255 0.214577419428602 no 710 0.210201543670339 1024 849217
SGTC_1761 st044296 37 µM 0.805625202998268 0.214605972840604 no 711 0.210229494536635 1077 1826700
SGTC_1108 betulinic acid 729.144 nM 0.804507141162045 0.21493550409337 no 712 0.210552073398617 1042 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3235 9132602 49.47 µM 0.803800746408018 0.215143854313027 no 713 0.210756029320177 1077 4912240
SGTC_2561 acetosyringone 100 µM 0.801447874136414 0.215838676002477 no 714 0.211436204646012 1102 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1025 k007-0731 70 µM 0.800814488556828 0.216025941670217 no 715 0.211619525009623 1048 6256118
SGTC_231 b-estradiol 524 µM 0.799268706086496 0.216483359935156 no 716 0.21206731021567 991 450 A steroid.
SGTC_53 0973-0023 39.979 µM 0.79776517807179 0.216928811727021 no 717 0.212503386160913 1042 674768
SGTC_3036 9090181 49.47 µM 0.797425663202479 0.217029473424711 no 718 0.212601929848757 1030 25236586
SGTC_2892 9047358 58.44 µM 0.796239635280634 0.21738132689712 no 719 0.212946382084266 993 6466771
SGTC_560 2332-1943 155 µM 0.795920888125222 0.217475944279501 no 720 0.213039009739152 1035 21177716
SGTC_794 k038-0031 316 µM 0.793923725583255 0.218069325881218 no 721 0.213619918317267 1062 6624242
SGTC_945 3381-0768 11.3 µM 0.79260973944553 0.21846023583334 no 722 0.214002616266976 1090 1126236 YIL048W NEO1
SGTC_1053 3366-3204 134 µM 0.792159620530584 0.218594238636142 no 723 0.214133804938331 1062 3632071 YPR165W RHO1
SGTC_354 2783-3500 4.88 µM 0.79178696962743 0.218705214595476 no 724 0.214242450698109 1008 6740761
SGTC_1474 0330-0125 5.35 µM 0.790629510055748 0.219050114375307 no 725 0.21458011056053 1093 X1474
SGTC_2665 lovastatin 100 µM 0.789157231426685 0.219489275574884 no 726 0.21501005768367 1065 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1866 st057638 64 µM 0.788468360032922 0.219694930347001 no 727 0.215211399339073 1031 688802
SGTC_1990 st072050 59.8 µM 0.786769873080293 0.220202466859935 no 728 0.215708296254346 1094 17233948
SGTC_20 0481-0013 4.944 µM 0.782478202761481 0.221487881839279 no 729 0.216966795253401 1072 182045
SGTC_313 3474-0040 5.03 µM 0.779181290937972 0.22247825940363 no 730 0.217936464704632 1067 1043375 YIL048W NEO1
SGTC_3189 9110682 49.47 µM 0.778058218291963 0.222816201186916 no 731 0.218267346344135 1075 17122418
SGTC_470 aa-861 153 µM 0.777437648123127 0.22300306124199 no 732 0.218450303905208 1093 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2774 tamoxifen 10.92 µM 0.776890297327139 0.223167948241466 no 733 0.218611748085074 1113 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1043 0916-0009 19.3 µM 0.776433220818799 0.223305693676799 no 734 0.218746617971649 1147 3101130
SGTC_3196 9111891 49.47 µM 0.775003393666131 0.223736901359397 no 735 0.219168827131397 1113 18891510
SGTC_884 0851-0618 334 µM 0.774899351686009 0.22376829683479 no 736 0.219199567635114 1089 9642473
SGTC_2261 9010538 184.68 µM 0.773838216990035 0.224088645459941 no 737 0.219513234669548 1008 6457250
SGTC_1801 st050089 28.441 µM 0.772180156740165 0.224589722585274 no 738 0.220003866246219 1121 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1151 3909-8316 15.3 µM 0.770642382817971 0.225055015960787 no 739 0.220459466094204 1071 800431
SGTC_2922 7999257 32.47 µM 0.770488811174412 0.225101513023755 no 740 0.220504994798386 1032 2988377
SGTC_2366 9070441 60.58 µM 0.769896134059586 0.225281009581824 no 741 0.220680753667662 1133 6837235
SGTC_998 3996-0085 177 µM 0.769526810901542 0.225392902757384 no 742 0.220790317313057 1133 715391
SGTC_2978 9011784 42.97 µM 0.769216868676014 0.225486829676583 no 743 0.220882289007635 1162 2994934
SGTC_1093 fluphenazine 7.97 µM 0.768956313279755 0.225565807226607 no 744 0.220959622710823 1156 6602611 An atypical antipsychotic.
SGTC_285 1486-1325 46 µM 0.768438600410927 0.225722778820106 no 745 0.221113327583635 1082 22310230
SGTC_2872 9044037 25.97 µM 0.767889977455542 0.225889189834273 no 746 0.221276276164376 1095 6465195
SGTC_2600 tangeritin 87.95 µM 0.766276507314892 0.226378997352664 no 747 0.221755896861478 1075 68077 A bioactive flavone.
SGTC_343 4130-2827 29.8 µM 0.766215061196371 0.226397662643421 no 748 0.221774174088045 1087 1118244
SGTC_3123 9126162 49.47 µM 0.766007621402478 0.226460682385232 no 749 0.221835883676301 1169 25239884
SGTC_1260 0700-1617 7.75 µM 0.764987051056547 0.226770873560961 no 750 0.222139627686704 1069 2853078
SGTC_1402 3909-7673 35.9 µM 0.764547092726617 0.226904667987352 no 751 0.222270642074025 1087 5328014
SGTC_1477 0139-0234 16 µM 0.763504464213232 0.227221916377635 no 752 0.222581300491715 1086 620880
SGTC_1607 st000305 50.6 µM 0.760088224802436 0.228263150707151 no 753 0.223600925362658 1079 5457690
SGTC_2864 9034755 47.6 µM 0.759418841025528 0.228467485732762 no 754 0.223801023172602 1125 4930451
SGTC_782 0083-0095 30.5 µM 0.759153705973411 0.228548448841062 no 755 0.223880307698016 1138 3591729 An indicator and reagent.
SGTC_1189 1431-2119 7.28 µM 0.758867585456881 0.228635838264095 no 756 0.223965885505718 1129 3107275
SGTC_1307 1187-1599 12.2 µM 0.758717346248309 0.228681733145847 no 757 0.224010829053611 1103 1538471
SGTC_3035 9091303 49.47 µM 0.757699371375697 0.228992839048354 no 758 0.224315487714255 1118 25237002
SGTC_89 0302-0250 142.109 µM 0.757035218336587 0.229195940494666 no 759 0.224514381601545 1197 4203518 YLR208W SEC13
SGTC_233 rapamycin 362 pM 0.75606124629962 0.229493968811942 no 760 0.224806237864153 1139 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1116 jasmonic acid 1.58368 µM 0.755734666545425 0.229593948421189 no 761 0.224904147482723 1110 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_426 0988-0037 14.6 µM 0.755493931132037 0.229667663137284 no 762 0.224976336176813 1130 5383008
SGTC_2 0422-0095 29 µM 0.755400614761655 0.229696240768784 no 763 0.22500432224237 1022 6790840
SGTC_3212 9128307 49.47 µM 0.754347136397961 0.230019000914428 no 764 0.225320402720368 1006 27243542
SGTC_646 4092-0839 27.3 µM 0.752916803308452 0.230457626127788 no 765 0.225749955011486 1137 877796
SGTC_2344 7990960 76.95 µM 0.752617878152154 0.230549353394873 no 766 0.225839785583164 1057 140813
SGTC_3074 9116018 49.47 µM 0.752613850956187 0.230550589307294 no 767 0.225840995941535 1135 17027303
SGTC_770 0389-1121 67.2 µM 0.752072754336703 0.230716680955369 no 768 0.226003653821014 1150 6753108
SGTC_2416 tofa 880 nM 0.751462854466348 0.230903972125299 no 769 0.226187073864262 1031 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_221 trifluoperazine 10.304 µM 0.749698819326281 0.231446158621578 no 770 0.22671805939451 1174 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3141 9094609 49.47 µM 0.749388755448403 0.231541531862562 no 771 0.226811463178139 1056 25236309 YDL196W YDL196W
SGTC_3114 9122766 49.47 µM 0.748687422944967 0.231757337093043 no 772 0.22702281296745 1037 17176985
SGTC_1447 4239-0816 81.9 µM 0.746426827313737 0.232453701366749 no 773 0.227704809215461 1090 1341554
SGTC_3221 9128209 49.47 µM 0.746113715329737 0.232550245489122 no 774 0.227799362422071 1106 16460723
SGTC_2856 9022925 19.48 µM 0.745380043378291 0.232776551259519 no 775 0.228021002378825 1094 4944862
SGTC_3273 9137859 49.47 µM 0.744733715462595 0.232976016556746 no 776 0.228216356431441 1186 2377234
SGTC_790 1575-0012 79.1 µM 0.743478247276237 0.233363741705162 no 777 0.228596093246412 1159 378741 YLR208W SEC13
SGTC_54 0159-0055 9 µM 0.74214101788041 0.233777110550141 no 778 0.229000950075303 1133 3319099
SGTC_3168 9103419 49.47 µM 0.742121216312734 0.233783234725028 no 779 0.229006948178464 1080 16649256
SGTC_1835 st008666 49.2 µM 0.74196401268641 0.23383185738912 no 780 0.229054569938167 1023 690455
SGTC_1527 coumarin 137 µM 0.740778393818239 0.23419874661516 no 781 0.229413908846951 1091 323 A hepatotoxic, DNA x-linker.
SGTC_917 harmaline 728.087 nM 0.740720876569243 0.234216553404133 no 782 0.229431349281606 1080 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3282 9108498 15.4605 µM 0.739663817537118 0.23454394218366 no 783 0.229752004007346 1101 16459645
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.739241203874816 0.234674903468722 no 784 0.229880272400406 1123 75037 A free radical scavenger.
SGTC_80 0159-0065 512.242 µM 0.739051931210972 0.234733569178835 no 785 0.229937731953925 1067 1548079
SGTC_2798 7813637 45.45 µM 0.738707820058739 0.234840248376786 no 786 0.230042218096052 1104 956368
SGTC_460 trequinsin 123 µM 0.738171055367533 0.235006706314122 no 787 0.230205254720723 1174 5537 A vasodilator.
SGTC_1126 isoteolin 1.0172 µM 0.736276202596337 0.235594846506904 no 788 0.230781312795647 1141 133323
SGTC_735 3076-0345 636 µM 0.735146734030719 0.235945806246995 no 789 0.231125067476281 1164 2888990
SGTC_1956 st077085 54 µM 0.733984287659608 0.236307313861469 no 790 0.231479157151199 1163 24208685
SGTC_2455 5377712 9.75 µM 0.733591052630751 0.236429674487089 no 791 0.231599007846503 1096 2243908
SGTC_3052 9092717 49.47 µM 0.733279822315081 0.23652654290849 no 792 0.231693889550768 1137 25237534
SGTC_642 0335-0876 158 µM 0.73246405467238 0.236780548923622 no 793 0.231942687315758 1150 6812350
SGTC_1848 st056003 16.4 µM 0.731328763991161 0.237134294513081 no 794 0.232289182620771 1206 146492
SGTC_3056 9094900 49.47 µM 0.730515630709326 0.237387837329155 no 795 0.232537531085359 1101 25236784
SGTC_1287 0971-0001 34.6 µM 0.729477309890347 0.237711812060317 no 796 0.232854871199066 1142 4665869
SGTC_1807 st050092 58.9 µM 0.728781076311033 0.237929185210687 no 797 0.233067794491987 1131 5008496
SGTC_3204 9114183 49.47 µM 0.728308869613236 0.23807667626559 no 798 0.233212267021515 1150 17027248
SGTC_644 1498-1197 63.3 µM 0.725563632601357 0.238935126959084 no 799 0.234053161226585 1180 6741615
SGTC_151 3013-0144 2.285 µM 0.724405506085397 0.239297786494561 no 800 0.234408410255486 1121 906558 YHR107C CDC12
SGTC_3130 9127414 49.47 µM 0.723742221977824 0.239505624807185 no 801 0.234612003355541 1195 1494646
SGTC_3222 9128301 49.47 µM 0.72316976619088 0.239685081516828 no 802 0.234787795566324 1198 4911358
SGTC_79 0052-0007 94.094 µM 0.722064483789514 0.240031779279961 no 803 0.235127416412127 1173 2801472
SGTC_999 SEC7.066 22.7 µM 0.721670553594235 0.240155410789986 no 804 0.235248525153456 1176 740511 YDR170C SEC7
SGTC_81 0411-0046 9.971 µM 0.721462502607902 0.240220719756485 no 805 0.235312501633401 1068 12925265
SGTC_2800 7887935 81.82 µM 0.720844670223712 0.240414719608886 no 806 0.235502544072185 1121 2961002
SGTC_1044 1222-0021 1.78 µM 0.719722329052511 0.240767353820798 no 807 0.23584798767475 1102 4306703
SGTC_1676 st018489 23.4 µM 0.719270042694546 0.24090953955096 no 808 0.235987275098716 1128 3696235
SGTC_1822 st052468 42 µM 0.718744855535358 0.241074700476563 no 809 0.23614907013047 1152 2873678
SGTC_1005 4092-0690 4.4 µM 0.713857351772092 0.242614671648283 no 810 0.237657695736856 1144 1529343
SGTC_1292 0kpi-0043 232 µM 0.713290608805003 0.242793586939355 no 811 0.237832973761879 1143 3333905
SGTC_1074 carmofur 3.8 µM 0.712907577816643 0.242914546556998 no 812 0.237951474856853 1210 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2449 5812982 45.77 µM 0.711074237729855 0.243493959086111 no 813 0.23851911668616 1117 776185
SGTC_2795 7780010 54.55 µM 0.710958041105886 0.243530707244973 no 814 0.238555118642567 1141 953673
SGTC_2203 7227154 166.4 µM 0.709444335899854 0.244009702823472 no 815 0.239024391440682 1176 896304
SGTC_1854 st056233 32.9 µM 0.708989276938564 0.244153800585674 no 816 0.239165565588482 1126 5393174
SGTC_1782 st039423 80.636 µM 0.708671530425326 0.244254444552437 no 817 0.239264167942016 1149 2068169
SGTC_1491 4138-0063 26.5 µM 0.707917977006824 0.24449321666866 no 818 0.239498097640249 1153 23883227
SGTC_2083 5306046 65.942 µM 0.706735786459356 0.244868060657392 no 819 0.239865342996945 1191 539837
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.705141514400912 0.245374055110414 no 820 0.240361086789467 1228 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_943 3253-1379 105 µM 0.703824602996696 0.245792443504082 no 821 0.240771005006428 1170 668464
SGTC_3044 9093193 49.47 µM 0.702723820154677 0.246142460563695 no 822 0.241113940036722 1158 25236277
SGTC_603 3794-0023 45.9 µM 0.70235411650972 0.246260075553182 no 823 0.241229176093024 1177 3802260
SGTC_1313 1220-0047 237 µM 0.701817471655188 0.246430853675681 no 824 0.241396500712419 1197 3528706
SGTC_949 1165-0505 146 µM 0.701332100494564 0.246585369458803 no 825 0.24154789259888 1209 6244267
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.701090668091534 0.246662247730145 no 826 0.241623216861233 1183 5379071
SGTC_387 norethindrone acetate 66.7 µM 0.698661357193035 0.247436516527708 no 827 0.242381844482974 1161 541197
SGTC_1425 4048-4433 7.33 µM 0.694322587049949 0.248822592346406 no 828 0.243739964577522 1253 23734946
SGTC_463 ikarugamyin 104 µM 0.693001972253278 0.249245298770213 no 829 0.244154156899663 1225 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1228 0124-0032 52.5 µM 0.690303830487317 0.250110113902154 no 830 0.245001569765508 1240 X1228
SGTC_1704 st028805 70.8 µM 0.690025841474367 0.25019930599493 no 831 0.245088968369145 1200 2876101
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.688220357311715 0.250779001472547 no 832 0.245657013085369 1264 65057 A dermal irritant. YDR527W RBA50
SGTC_771 0250-0039 27.3 µM 0.686722060004396 0.251260606398542 no 833 0.246128946403278 1192 3005115
SGTC_3045 9092950 49.47 µM 0.685321185134553 0.251711338357902 no 834 0.246570633107889 1237 44120432
SGTC_1284 0929-0043 16 µM 0.684018484385987 0.252130865606657 no 835 0.246981746851744 1194 1239883
SGTC_1485 3909-9022 254 µM 0.682376314589969 0.252660241949143 no 836 0.247500514325985 1237 714516
SGTC_1775 st081588 35.1725 µM 0.681802353929449 0.252845404138718 no 837 0.247681967819681 1249 1426443 YGL099W LSG1
SGTC_3286 9117135 37.221 µM 0.681356354280098 0.252989334856888 no 838 0.247823016406754 1184 3438150
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.681005070691757 0.253102729637368 no 839 0.24793414096558 1196 15053
SGTC_1090 efavirenz 20.7 µM 0.679968263618311 0.25343756809634 no 840 0.248262278075345 1246 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_405 ebelactone b 50 µM 0.677654707338279 0.254185573167049 no 841 0.2489953251817 1225 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_302 1094-0063 18.9 µM 0.675908538581376 0.254750899636761 no 842 0.249549358097908 1181 5440289
SGTC_1804 st050076 49.1 µM 0.674656999914154 0.255156493014089 no 843 0.249946854955712 1242 3895976
SGTC_1149 3909-7961 23.3 µM 0.674490759476595 0.255210392910851 no 844 0.249999679274407 1199 735261
SGTC_482 fipronil 114 µM 0.668155823080524 0.257268787895693 no 845 0.252017065732735 1263 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1340 1486-1359 257 µM 0.666994165157173 0.257647176626659 no 846 0.252387930229184 1209 4309068
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.666226366157589 0.257897431569239 no 847 0.252633211307066 1269 4213774
SGTC_1066 ketoconazole 628 nM 0.665347046228138 0.258184190281911 no 848 0.252914273024735 1269 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3070 9117005 49.47 µM 0.665132091509017 0.258254315202158 no 849 0.252983005171605 1276 8779016
SGTC_74 000s-0487 160.283 µM 0.663650034764209 0.258738076786484 no 850 0.253457162777232 1200 677548
SGTC_2018 5133068 143 µM 0.663397535078554 0.258820542531975 no 851 0.253537992080381 1249 785362
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.662798459668844 0.259016253415198 no 852 0.253729820143113 1272 279621
SGTC_2477 5967686 25.23 µM 0.661888861056039 0.259313554829642 no 853 0.254021225507501 1239 776118
SGTC_818 4072-2707 53.5 µM 0.661049614181879 0.259588018162819 no 854 0.25429024815982 1199 882871
SGTC_2974 9094440 9.66 µM 0.660298778478388 0.259833694980305 no 855 0.254531056925289 1309 25236134
SGTC_2148 5546263 113.568 µM 0.6602735589466 0.259841949006311 no 856 0.254539147431647 1246 792097
SGTC_518 1021-0119 62.6 µM 0.659624056091536 0.260054569470011 no 857 0.254747556427346 1204 1097762
SGTC_2448 5185112 27.17 µM 0.658348970733949 0.260472240621844 no 858 0.255156958697595 1243 5718189
SGTC_3013 9080133 71.4286 µM 0.65814619128411 0.260538695548161 no 859 0.255222098480122 1325 17050193
SGTC_2521 angolensin 13.4 µM 0.657756047568583 0.26066657808349 no 860 0.255347450607757 1274 821428 A flavenoid.
SGTC_2092 5303694 80.6725 µM 0.657626934072881 0.260708906425207 no 861 0.255388941512776 1258 1963699
SGTC_776 4476-4378 112 µM 0.657368834446075 0.26079353195521 no 862 0.255471892954085 1246 2892008
SGTC_3329 9141233 27.5565 µM 0.656463705294064 0.261090416729329 no 863 0.255762906436523 1253 4909101 YNL103W MET4
SGTC_36 0335-0881 14.2 µM 0.654790792432927 0.261639593525754 no 864 0.256301229823073 1217 23828853
SGTC_2938 9059746 27.26 µM 0.654679354742215 0.261676196870761 no 865 0.25633711011112 1228 6471769
SGTC_2189 6047310 154.431 µM 0.654481754991036 0.261741107869208 no 866 0.256400738971091 1203 711535
SGTC_786 4544-0069 423 µM 0.653395962225971 0.26209793528998 no 867 0.256750520613689 1289 748821 YLR208W SEC13
SGTC_2647 atorvastatin 60.16 µM 0.65329933173339 0.262129703343258 no 868 0.256781661581406 1259 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_769 0302-0231 76 µM 0.652905101546712 0.262259330138361 no 869 0.256908729937579 1266 571869 YER009W NTF2
SGTC_614 0462-0418 107 µM 0.652599289752669 0.26235990670019 no 870 0.257007321788534 1167 5188303
SGTC_2907 7721985 69.9 µM 0.652292027858605 0.262460980066152 no 871 0.257106400961232 1226 3267881
SGTC_2782 7736369 71.43 µM 0.651964220731889 0.262568833731732 no 872 0.257212127012433 1302 2950836 YOL077C BRX1
SGTC_1504 k297-0033 30 µM 0.651488671808393 0.262725337067841 no 873 0.257365543681365 1166 4388117
SGTC_1285 0929-0069 65.5 µM 0.650180387206396 0.263156140128883 no 874 0.25778785413989 1267 1206237
SGTC_2997 9067075 71.4286 µM 0.649994823359028 0.263217273380133 no 875 0.257847782720628 1259 27209819
SGTC_3155 9099265 49.47 µM 0.649087835828025 0.26351618106196 no 876 0.258140801933573 1234 25236499
SGTC_1627 st003713 25.6 µM 0.647486496543446 0.264044342571899 no 877 0.258658565597494 1301 16195070 YER133W GLC7
SGTC_3325 9138760 55.175 µM 0.64695953877418 0.264218264227365 no 878 0.258829065215091 1250 43844959
SGTC_1046 2001-0062 216 µM 0.6464867979195 0.264374341300598 no 879 0.258982072172796 1231 739778
SGTC_953 1188-0045 9.7 µM 0.646112675028651 0.264497892561715 no 880 0.259103193665927 1270 6144426
SGTC_1438 4092-1045 4 µM 0.645706589827772 0.264632032380162 no 881 0.259234696029859 1258 1351342
SGTC_2936 9038235 15.59 µM 0.645689091664158 0.264637813226733 no 882 0.259240363226382 1268 4749415
SGTC_1481 3346-2004 36 µM 0.645648793688334 0.264651126663228 no 883 0.259253414927968 1273 2770522
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.644450769978597 0.265047079074178 no 884 0.259641585705449 1296 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2691 st077356 60.2 µM 0.644270390298533 0.265106721454463 no 885 0.259700056368985 1320 2839272
SGTC_3205 9113483 49.47 µM 0.644245044536947 0.265115102554118 no 886 0.259708272825078 1271 17018033
SGTC_2377 9073351 62.6 µM 0.643126212350829 0.265485201567093 no 887 0.260071103611131 1238 7337946 YHR072W ERG7
SGTC_2071 5230951 39.92 µM 0.6411988934344 0.266123354378202 no 888 0.26069673424632 1303 1799272
SGTC_1728 st035614 33.7865 µM 0.641092039066701 0.26615875754319 no 889 0.260731443091886 1315 15945546
SGTC_1940 st075990 51.1 µM 0.640842972217173 0.266241288037909 no 890 0.260812355171319 1370 1084979
SGTC_1030 k029-0042 36.7 µM 0.640819588065355 0.266249037247761 no 891 0.260819952431062 1321 6080581
SGTC_1040 k898-0338 155 µM 0.639740593020722 0.266606726578928 no 892 0.261170630112013 1333 20969351
SGTC_2200 6600604 21.907 µM 0.639480894934184 0.266692853353473 no 893 0.261255069186634 1242 2904777
SGTC_2407 paclitaxel 400 µM 0.638528492400386 0.267008830290839 no 894 0.261564856420729 1412 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1421 4029-0249 71.4 µM 0.638219716915535 0.267111312766767 no 895 0.261665332043869 1370 2894095
SGTC_962 1254-0300 21.5 µM 0.638075169679773 0.267159294767168 no 896 0.2617123745572 1273 7340576
SGTC_885 0865-0106 16.8 µM 0.637595115079029 0.267318678594892 no 897 0.261868638180769 1245 2793380
SGTC_67 0335-0847 266 µM 0.634892231584995 0.268216962566907 no 898 0.2627493519874 1404 4552207 YOR254C SEC63
SGTC_510 ag-490 170 µM 0.633814891541543 0.268575431681599 no 899 0.263100816791891 1401 5328779
SGTC_870 0573-2213 57.6 µM 0.633512280123846 0.268676164496933 no 900 0.26319958208188 1279 3916321
SGTC_3147 9097027 49.47 µM 0.633154399993983 0.268795319570268 no 901 0.263316410226004 1337 25236841
SGTC_2726 cimetidine 79.27 µM 0.633146527975985 0.268797940832418 no 902 0.263318980303771 1281 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_900 1112-0045 141 µM 0.631516007184303 0.269341156022022 no 903 0.263851593117122 1220 56211 YIL048W NEO1
SGTC_2335 9018011 154.17 µM 0.629856664188692 0.269894538026185 no 904 0.264394184103361 1331 6458208
SGTC_361 000s-0510 1.45 µM 0.629410841508659 0.27004331444194 no 905 0.264540061048528 1289 660
SGTC_2903 5923464 63.88 µM 0.629372680723271 0.270056051063418 no 906 0.26455254948208 1326 2876576
SGTC_2923 7992654 58.14 µM 0.627833089674892 0.270570158646798 no 907 0.265056643462895 1321 2985126
SGTC_961 1252-1571 372 µM 0.627758054819077 0.270595227132334 no 908 0.265081223892361 1340 6813498
SGTC_1561 5-methoxyflavone 52.9 µM 0.627584588617774 0.270653185105654 no 909 0.26513805356513 1260 94525
SGTC_500 h-89 112 µM 0.626768989743842 0.270925773469837 no 910 0.265405336758484 1385 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2598 perillyl alcohol 100 µM 0.625167872382931 0.271461294892863 no 911 0.265930442775067 1335 10819 An apoptosis inducer.
SGTC_3300 9124615 50.48 µM 0.624607120822646 0.271648972560863 no 912 0.266114472487097 1357 24824903
SGTC_1024 4507-0395 26 µM 0.623760180186218 0.271932557123798 no 913 0.266392547091571 1334 4201836
SGTC_3256 9138902 49.47 µM 0.623538596750345 0.272006775099025 no 914 0.266465323467051 1329 17228773
SGTC_2921 7974240 10.71 µM 0.623076371283129 0.272161627022766 no 915 0.266617168145767 1330 2979074 YDR527W RBA50
SGTC_1663 st014140 55.4 µM 0.6229539036569 0.272202662713092 no 916 0.266657407048406 1375 4207120
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.622624407556353 0.272313083480866 no 917 0.26676568405478 1336 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2383 9036125 200 µM 0.622418456563087 0.272382113099898 no 918 0.266833373701725 1262 79580
SGTC_1708 st033234 31.827 µM 0.622025664827241 0.272513791152594 no 919 0.266962496109719 1375 674664
SGTC_968 1309-0633 340 µM 0.621989936761888 0.272525770065494 no 920 0.26697424256056 1298 3761976
SGTC_2279 7948423 32.93 µM 0.618921147536414 0.273555648885052 no 921 0.267984153128439 1388 1247112
SGTC_2118 5526350 200 µM 0.617745018651074 0.273950865044895 no 922 0.268371715676145 1342 743594
SGTC_2617 dihydrotanshinone i 20.83 µM 0.616863709097983 0.274247197532818 no 923 0.26866231285345 1333 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3175 9106517 49.47 µM 0.616410073673657 0.274399790087922 no 924 0.268811953208009 1286 41468073
SGTC_2470 5664817 21.68 µM 0.615970532107902 0.27454768175558 no 925 0.268956984351908 1343 2859561
SGTC_1252 0493-0875 34.8 µM 0.61587333812912 0.274580389726852 no 926 0.268989059781838 1320 3960963
SGTC_1155 4088-0394 48.2 µM 0.615441785049029 0.274725640306471 no 927 0.269131501776427 1277 2326248
SGTC_1183 1254-0324 198 µM 0.614740055418122 0.274961906795492 no 928 0.26936320126465 1353 5799357
SGTC_2517 totarol 10 µM 0.613699670026277 0.275312379986093 no 929 0.269706903233213 1274 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1098 clofazimine 15.1 µM 0.613623168232066 0.275338159715105 no 930 0.269732185051492 1364 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2399 5884133 200 µM 0.611923649425377 0.275911173138916 no 931 0.270294136919123 1312 722445
SGTC_1778 st046819 58.9 µM 0.611382663025742 0.276093696114025 no 932 0.270473138709272 1345 671715
SGTC_1480 1070-0044 41.2 µM 0.611278482670602 0.276128852247686 no 933 0.270507616746288 1348 3124987
SGTC_1196 1588-0294 184 µM 0.60913390570808 0.276853037293778 no 934 0.2712178426818 1307 6144269
SGTC_2836 9010338 19.48 µM 0.608588733624236 0.277037280269507 no 935 0.271398537026541 1211 2994051
SGTC_336 4111-0029 111 µM 0.607897661127949 0.277270917064628 no 936 0.271627675450867 1277 3131175
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.607020146526873 0.27756772474431 no 937 0.271918771093274 1338 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_839 0122-0028 230 µM 0.606149567457369 0.277862339901714 no 938 0.272207719295165 1319 759448
SGTC_717 1532-0246 73.2 µM 0.604050928098891 0.278573173377009 no 939 0.272904891666431 1311 9561992
SGTC_820 1582-0060 59.9 µM 0.603949056117102 0.278607701125321 no 940 0.272938756273028 1317 3848840
SGTC_1267 0828-0272 9.49 µM 0.603066768237002 0.27890682451758 no 941 0.273232136345348 1404 745334
SGTC_2414 st077232 92.9 µM 0.602605522441393 0.27906326354509 no 942 0.273385572850187 1297 729801
SGTC_1698 5-fluorocytosine 1.055 µM 0.602530611859779 0.279088674716623 no 943 0.273410496383895 1371 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2028 5153890 36.43 µM 0.60241548016309 0.279127731890285 no 944 0.273448804096239 1304 2830968 YPR165W RHO1
SGTC_592 k241-0073 46.5 µM 0.601246638057878 0.279524399202632 no 945 0.273837862707049 1373 4230158
SGTC_3328 9140624 29.0385 µM 0.599923202728296 0.279973860611119 no 946 0.274278709080014 1363 4904392
SGTC_2830 7992007 71.43 µM 0.599909084948498 0.27997865714032 no 947 0.274283413708266 1346 1952075
SGTC_377 3970-0964 33.1 µM 0.599601705562672 0.280083099456595 no 948 0.274385855112211 1367 16481235
SGTC_1947 st076332 61.6 µM 0.598642840835078 0.280409026749792 no 949 0.27470554061296 1337 24208416
SGTC_27 0485-0001 32.618 µM 0.59841575362013 0.280486242751774 no 950 0.274781278381211 1293 2054479
SGTC_3112 9123419 49.47 µM 0.597661775712582 0.280742690108745 no 951 0.275032817705621 1371 17015854
SGTC_3046 9092212 49.47 µM 0.596370100396813 0.281182285593654 no 952 0.275464005087381 1363 25236637
SGTC_289 k017-0060 526 µM 0.592316741941563 0.282563918156862 no 953 0.276819253487421 1333 5512909
SGTC_1097 itavastatin 7.23 µM 0.592138547951245 0.282624732387295 no 954 0.276878907860867 1367 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3280 9140961 49.47 µM 0.590815966402423 0.283076300910011 no 955 0.277321867904487 1335 4901226
SGTC_2905 7799065 20.05 µM 0.590645423002465 0.283134554673615 no 956 0.277379011647389 1332 1296806
SGTC_483 fpl-64176 144 µM 0.588508042807046 0.283865122716132 no 957 0.2780956684947 1379 3423
SGTC_2963 9082507 9 µM 0.588280556075886 0.283942932002244 no 958 0.278171997228082 1370 16459611
SGTC_2610 ononetin 44.17 µM 0.587897581322428 0.284073947273393 no 959 0.278300520006885 1342 259632
SGTC_526 4469-0568 170 µM 0.587793607425896 0.284109521627301 no 960 0.278335417678736 1342 2901964
SGTC_2400 5203494 178.7 µM 0.587421447684252 0.28423687241566 no 961 0.27846034639877 1321 6777674
SGTC_1764 st044502 93.5 µM 0.585901785398605 0.284757174604402 no 962 0.2789707587272 1330 8407
SGTC_538 2922-0838 53.3 µM 0.585541837299461 0.284880480235259 no 963 0.279091721918491 1435 777039
SGTC_591 4299-0174 154 µM 0.585049475458201 0.285049187422441 no 964 0.27925722500651 1366 5509088
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.584286651180699 0.285310662267388 no 965 0.279513735809014 1408 688761
SGTC_2282 7944268 200 µM 0.58340280416505 0.285613763133798 no 966 0.279811085275156 1422 2970414
SGTC_3021 9087658 49.47 µM 0.581816126881182 0.286158272269928 no 967 0.280345270078567 1345 25237042
SGTC_143 4032-1194 15.74 µM 0.581679463357829 0.286205194929688 no 968 0.280391303518554 1383 1806963
SGTC_337 1315-0038 354 µM 0.581095615515942 0.286405696976722 no 969 0.28058800674459 1352 1626437
SGTC_1080 nisoldipine 24.4 µM 0.580080892586597 0.286754326478526 no 970 0.280930034180628 1343 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_823 0417-1665 178 µM 0.57935373104146 0.287004281863323 no 971 0.281175258659685 1390 3429856
SGTC_2703 st077852 53.4 µM 0.578967320822921 0.287137148953927 no 972 0.281305611841875 1373 6281836
SGTC_3345 9148410 3.559 µM 0.578404343535052 0.287330780707637 no 973 0.281495581069257 1366 4903596
SGTC_3283 9109332 35.8195 µM 0.578167334138205 0.287412316760897 no 974 0.281575575258616 1313 17027281
SGTC_983 1491-0821 12.2 µM 0.577380575952584 0.287683056011472 no 975 0.2818411964014 1395 46495113
SGTC_297 0986-0032 24 µM 0.576868112563032 0.28785946972077 no 976 0.282014276498881 1339 2847425
SGTC_528 3492-0019 172 µM 0.576628564666658 0.287941950756178 no 977 0.282095199291605 1411 2869262
SGTC_548 1436-0017 110 µM 0.576294259556061 0.288057077206272 no 978 0.282208151146453 1456 9677137
SGTC_2618 avocadyne 43.43 µM 0.571742107378972 0.289626884063962 no 979 0.28374835160752 1357 3015189
SGTC_1803 st050068 52.4 µM 0.570042589325868 0.290213989617112 no 980 0.284324406145752 1450 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1521 st012942 49.4 µM 0.568586736984486 0.290717362785068 no 981 0.28481831382914 1511 24207259
SGTC_3356 9151811 4.48 µM 0.568495311904669 0.290748987395164 no 982 0.284849344058047 1366 1859254 YPR165W RHO1
SGTC_808 0711-0032 135 µM 0.566092750057483 0.291580627278455 no 983 0.285665365742137 1383 4252555
SGTC_215 1287-0124 461.5 µM 0.565918109590351 0.291641121791562 no 984 0.285724725099915 1460 5560863
SGTC_120 rhodamine 6G 52.259 µM 0.565298224751814 0.291855893772868 no 985 0.28593546799273 1380 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_693 4161-2696 114 µM 0.565056139807488 0.291939789131642 no 986 0.286017789921024 1458 805759
SGTC_2468 5987765 72.9 µM 0.564175046619054 0.292245229745763 no 987 0.28631750415186 1446 26772094
SGTC_1777 st045864 34.765 µM 0.563382883705578 0.292519968548067 no 988 0.286587094925939 1389 4691462
SGTC_1693 xanthone 101.9 µM 0.562858899126582 0.292701763381726 no 989 0.286765484743898 1436 7020 An insecticide.
SGTC_788 1182-0090 188 µM 0.562487012997937 0.292830819955597 no 990 0.28689212478457 1533 5715185
SGTC_2401 5128683 200 µM 0.559553630987555 0.293849723582599 no 991 0.287891970143921 1316 708373
SGTC_2846 9008642 19.48 µM 0.559013657329492 0.294037460794836 no 992 0.28807619972777 1392 2992898
SGTC_2824 7998404 51.95 µM 0.5588919343866 0.294079788897693 no 993 0.288117737153874 1415 837851
SGTC_3079 9117512 49.47 µM 0.55802813334552 0.294380249130142 no 994 0.288412586668551 1466 7185044
SGTC_893 0958-0369 48.9 µM 0.557873763404382 0.294433959322706 no 995 0.288465294221901 1483 6819948
SGTC_2479 5617353 43.85 µM 0.556418614082958 0.294940474018154 no 996 0.28896235845972 1457 2731746
SGTC_2024 5144227 134 µM 0.556208679824773 0.295013581975995 no 997 0.289034103121678 1432 3475211
SGTC_628 1636-0253 16 µM 0.554423530620527 0.295635583205538 no 998 0.289644513001182 1437 4456143
SGTC_1423 4048-0112 5.59 µM 0.553526329240989 0.295948423378918 no 999 0.289951528328451 1445 X1423
SGTC_1234 0326-0494 15.5 µM 0.553338197231887 0.296014041358559 no 1000 0.290015924985544 1481 1547813
SGTC_2185 6113692 200 µM 0.552932275331331 0.296155644344109 no 1001 0.290154892881924 1400 874150
SGTC_3341 9147222 25.867 µM 0.552822041955929 0.296194103843056 no 1002 0.290192636809473 1400 1939759
SGTC_2567 aureobasidin a 60 nM 0.552427911067583 0.296331631537036 no 1003 0.290327606108508 1490 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_118 0083-0097 135.343 µM 0.552412786027157 0.296336909838979 no 1004 0.290332786232656 1454 5207356
SGTC_235 0330-0087 5 mM 0.551884197392738 0.296521402560979 no 1005 0.290513847955062 1383 46494818 YHR062C RPP1
SGTC_1568 digitonin 820 nM 0.551299412828349 0.296725570585823 no 1006 0.290714220470352 1523 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_3003 9075612 71.4286 µM 0.54970786161989 0.29728156052557 no 1007 0.29125988189846 1409 6501993
SGTC_1978 st071761 42 µM 0.548316150655122 0.297768128376002 no 1008 0.291737419783923 1371 5147680
SGTC_3069 9117009 49.47 µM 0.547990592799331 0.297882001821146 no 1009 0.291849181111585 1343 41904981
SGTC_1019 4262-0212 3.4 µM 0.547630561927803 0.298007956334887 no 1010 0.291972799960251 1448 4677213
SGTC_1678 st019265 80.2 µM 0.547192827451508 0.298161127648609 no 1011 0.292123131660474 1524 5367020
SGTC_1048 3161-0300 24.5 µM 0.546008482226142 0.298575731403288 no 1012 0.292530053300516 1389 2165101
SGTC_1815 st051655 58.2 µM 0.543782674530462 0.299355628535764 no 1013 0.293295516288657 1399 5984156
SGTC_2666 tannic acid 100 µM 0.540619004551135 0.300465728628686 no 1014 0.29438510798629 1453 16134267 A thiamine antagonist.
SGTC_1980 st071811 45.7 µM 0.54022654459381 0.300603568441341 no 1015 0.294520404340261 1464 4974850
SGTC_562 3772-2733 112 µM 0.539554808865505 0.300839561733111 no 1016 0.294752044581499 1418 2876874 YIL048W NEO1
SGTC_1929 genistein trimethyl ether 50.5 µM 0.539198572311503 0.300964748181785 no 1017 0.29487492268599 1538 136420
SGTC_428 3448-4153 16.5 µM 0.53831906509636 0.301273919700674 no 1018 0.295178395696597 1361 3834874
SGTC_851 0394-0702 453 µM 0.538220964929905 0.301308413532895 no 1019 0.295212253964656 1452 762646
SGTC_2333 9017922 200 µM 0.537065784735976 0.301714729938821 no 1020 0.295611086991758 1565 3163164
SGTC_3321 9137793 26.8275 µM 0.536094477248912 0.302056562555418 no 1021 0.295946628412653 1419 4904192
SGTC_2646 retinol 96.75 µM 0.535849976082594 0.302142637335932 no 1022 0.296031119700806 1426 445354 A vitamin A analog and teratogen.
SGTC_2804 7954240 19.48 µM 0.534587705702387 0.302587185093038 no 1023 0.296467493443053 1497 828705
SGTC_2810 7959871 45.46 µM 0.534090213812875 0.302762472825573 no 1024 0.296639560049983 1505 2974535
SGTC_1736 st036774 51 µM 0.533706524411914 0.302897694115553 no 1025 0.29677229723248 1544 1272247
SGTC_2031 5180455 200 µM 0.533088788583855 0.303115455726296 no 1026 0.296986059784464 1392 29949
SGTC_2411 st077133 39.94 µM 0.532768312460255 0.303228456189214 no 1027 0.297096985729851 1582 1403142 YNL221C POP1
SGTC_1431 4049-0260 9.09 µM 0.532566212265647 0.303299726767232 no 1028 0.297166948122283 1433 3854841
SGTC_1606 st000094 49.2 µM 0.530576229955971 0.304001892924022 no 1029 0.297856235580611 1480 1242210
SGTC_1983 st071813 46.9 µM 0.528321390451854 0.304798388626074 no 1030 0.298638143801514 1434 11838595
SGTC_549 1661-1316 519 µM 0.526126568028028 0.305574573578003 no 1031 0.299400135134552 1523 2857282
SGTC_335 4077-0256 27.6 µM 0.524753844873497 0.306060473178834 no 1032 0.299877160398945 1460 3121989
SGTC_798 1287-0182 476 µM 0.523942300407571 0.306347894333339 no 1033 0.300159336169453 1539 1649755
SGTC_2308 7584454 197.62 µM 0.523829243811817 0.306387944556866 no 1034 0.300198655719664 1538 893577
SGTC_1483 3453-0561 55.9 µM 0.523381977500982 0.30654641102166 no 1035 0.300354231700322 1477 4546991
SGTC_2759 disulfiram 3.38 µM 0.522311924202632 0.306925677700554 no 1036 0.30072658409481 1392 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_201 4262-0159 12.803 µM 0.521637576701225 0.307164797751699 no 1037 0.300961347493228 1485 1341029
SGTC_2934 9036370 36.88 µM 0.519674517747382 0.307861354703711 no 1038 0.301645225272477 1557 6462800
SGTC_1011 4112-3381 17.4 µM 0.518919089734256 0.308129589834236 no 1039 0.301908582491456 1493 2877139
SGTC_2483 5729050 27.16 µM 0.51877468154021 0.30818087754144 no 1040 0.301958937817356 1579 2865180
SGTC_1590 st077108 57.8 µM 0.518526196542705 0.308269137711742 no 1041 0.302045593690804 1467 5489485
SGTC_2051 5263410 176 µM 0.518186676187615 0.308389750938653 no 1042 0.302164014998156 1468 227584
SGTC_2695 st077686 51.995 µM 0.517549530034516 0.308616150345829 no 1043 0.302386301441895 1418 2876092
SGTC_2009 4012297 12.05 µM 0.517111420612973 0.308771867554063 no 1044 0.302539190836768 1445 45595307
SGTC_1540 guanosine 70.6 µM 0.516760816823709 0.308896507411631 no 1045 0.302661567876426 1433 6802 Guanosine is a purine nucleoside
SGTC_224 benfluorex 43.875 µM 0.516186808435079 0.309100615249529 no 1046 0.302861971383157 1525 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1356 1502-0781 85.8 µM 0.514246589562278 0.309790960872272 no 1047 0.303539799197703 1444 567702
SGTC_2634 4'-methoxyflavone 100 µM 0.513035254720508 0.310222304245884 no 1048 0.303963329951189 1479 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2627 acetyl isogambogic acid 100 µM 0.511958374396438 0.310605989179783 no 1049 0.304340071155107 1398 6857789 A caspase activator and apoptosis inducer.
SGTC_2058 5236698 133 µM 0.510941651202857 0.310968429731888 no 1050 0.304695957369342 1481 766665
SGTC_3303 9125618 40.5795 µM 0.510697456414557 0.311055507399107 no 1051 0.304781461045943 1551 22695467
SGTC_536 3852-0578 10.6 µM 0.509073347114857 0.311634919135457 no 1052 0.305350406544668 1561 2869208
SGTC_2731 amoxapine 43.43 µM 0.509043429257123 0.311645596911002 no 1053 0.305360891556536 1538 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_768 0384-0033 77.3 µM 0.506636196759459 0.312505264008989 no 1054 0.306205052928387 1438 3965305 YMR134W ERG29
SGTC_1476 4112-3294 3.34 µM 0.506488108195652 0.312558182557615 no 1055 0.30625701787345 1546 704369
SGTC_1159 4092-0538 61.2 µM 0.505593943490189 0.312877788973244 no 1056 0.306570867091912 1517 717301
SGTC_3258 9138477 49.47 µM 0.504299684521792 0.313340652558506 no 1057 0.307025399564309 1515 4970355
SGTC_1328 1441-0025 69.2 µM 0.501797071626047 0.314236491555928 no 1058 0.307905136617727 1390 4562601
SGTC_1506 4226-2149 212 µM 0.501431466520485 0.314367455922576 no 1059 0.308033749480649 1524 991114
SGTC_2099 5377090 177.372 µM 0.500531761642248 0.314689841059635 no 1060 0.308350348784681 1454 2243829
SGTC_1973 st070275 50.2 µM 0.499530007631405 0.315048959028506 no 1061 0.30870302618042 1463 17118334
SGTC_679 0422-0091 41.4 µM 0.499499171573267 0.315060016197907 no 1062 0.308713885121226 1447 627384 YHR062C RPP1
SGTC_1769 st044406 64.4 µM 0.498077487618223 0.31556998233056 no 1063 0.309214713676003 1488 670903
SGTC_3157 9099274 49.47 µM 0.497523960476777 0.315768630773454 no 1064 0.309409805329046 1485 17217662
SGTC_1825 st052143 62.6 µM 0.497182055313878 0.315891359445047 no 1065 0.309530337277844 1533 674173
SGTC_2350 9023895 38.85 µM 0.49711192348394 0.315916536146533 no 1066 0.309555063409788 1553 2997209
SGTC_2704 st078022 71.1 µM 0.494473535866051 0.316864313257124 no 1067 0.310485895858019 1592 54697681
SGTC_1690 st023502 41.2 µM 0.493153113087216 0.317339095444843 no 1068 0.310952202227548 1556 24207482
SGTC_1179 1021-1431 9.29 µM 0.492844177425716 0.317450222357894 no 1069 0.311061346507002 1507 2840958
SGTC_1057 3448-5381 134 µM 0.492358199987228 0.317625066076138 no 1070 0.311233071736022 1594 5497911
SGTC_3334 9142812 21.919 µM 0.492124466232192 0.317709172699923 no 1071 0.31131567864895 1530 45283678
SGTC_1144 3486-0183 12.5 µM 0.491734568808945 0.317849494105242 no 1072 0.311453498557737 1492 6744069
SGTC_94 0334-0113 514.748 µM 0.491507964604625 0.317931059424503 no 1073 0.311533610155335 1428 6795178
SGTC_2338 7999974 200 µM 0.49091367051354 0.31814501527116 no 1074 0.311743753884597 1566 315925
SGTC_1849 st056239 19.2 µM 0.490710513014826 0.318218169304804 no 1075 0.311815604900004 1397 5393181
SGTC_1887 st057648 70.8 µM 0.489914061285827 0.318505028251127 no 1076 0.312097356237743 1601 688672
SGTC_314 1671-0008 2.74 µM 0.488772914773135 0.318916225968723 no 1077 0.312501237790923 1443 3913060
SGTC_575 k072-0246 11.9 µM 0.487775808762493 0.319275703086944 no 1078 0.312854324126243 1506 6796779
SGTC_856 0433-0016 11.3 µM 0.486293935223575 0.319810262758088 no 1079 0.313379389294333 1508 3911780
SGTC_1951 sophoraflavanone G 9.2 µM 0.482677522505092 0.321116389981867 no 1080 0.314662362770078 1488 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2605 digitonin 300 nM 0.481101535315691 0.321686278128711 no 1081 0.315222168476178 1553 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_294 k038-0071 157 µM 0.479476076401424 0.322274495428586 no 1082 0.315799991813545 1514 24152826
SGTC_1930 st074634 34.3 µM 0.479258018992856 0.322353439447561 no 1083 0.315877541857176 1455 684253 YOR116C RPO31
SGTC_1959 st077091 55.8 µM 0.477130421228186 0.323124120473517 no 1084 0.316634626664121 1493 821356 YKL052C ASK1
SGTC_3110 9122132 49.47 µM 0.476481962775328 0.323359163215827 no 1085 0.316865527264394 1594 918317
SGTC_838 0109-0203 71.4 µM 0.476338183149881 0.323411287685368 no 1086 0.316916733429439 1499 759422
SGTC_1696 st025591 34.7925 µM 0.475297661402694 0.323788611587124 no 1087 0.317287412863753 1525 2787147
SGTC_547 1120-0019 610 nM 0.474497844998899 0.324078771811562 no 1088 0.317572467171105 1540 3676939
SGTC_2558 carylophyllene oxide 100 µM 0.474193534547207 0.32418919871822 no 1089 0.317680951741019 1572 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_580 1123-0028 41 µM 0.474176561224635 0.32419535838219 no 1090 0.317687003074077 1541 1677248 YPR107C YTH1
SGTC_3240 9133527 49.47 µM 0.472333564824807 0.324864472658384 no 1091 0.318344358058598 1503 17617455
SGTC_2313 7726885 200 µM 0.470249198037756 0.325621899686541 no 1092 0.31908849414633 1525 726423
SGTC_305 1682-2595 20.8 µM 0.469568142221003 0.325869541293884 no 1093 0.319331794970761 1553 226033
SGTC_751 0833-0568 350 µM 0.468889782670512 0.326116278890357 no 1094 0.319574209938426 1572 6954252
SGTC_3118 9124250 49.47 µM 0.468028303518807 0.326429731747894 no 1095 0.319882174698416 1492 1504786
SGTC_2822 7994718 71.43 µM 0.467553680620563 0.326602477708799 no 1096 0.320051897723412 1553 1018011
SGTC_2658 polymyxin b sulfate 77.05 µM 0.465847742258322 0.327223685793519 no 1097 0.320662244445362 1512 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_355 1311-2252 105 µM 0.464988740339572 0.32753666801717 no 1098 0.320969759956508 1502 5338538
SGTC_725 1497-0963 19 µM 0.464594373421031 0.32768039846331 no 1099 0.321110981177957 1672 3549977
SGTC_2776 terbinafine 19.92 µM 0.463711397179831 0.328002299388307 no 1100 0.321427265253875 1515 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1875 nocodazole 6 µM 0.462139458890626 0.328575686925317 no 1101 0.32199065751872 1571 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2765 myclobutanil 7.74 µM 0.460586486647495 0.329142552973086 no 1102 0.322547654288894 1534 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1646 st011709 75.6 µM 0.458739096064994 0.329817399515638 no 1103 0.323210767572131 1607 5757843
SGTC_260 nsc-65238 3.989 µM 0.458010124194809 0.330083843527909 no 1104 0.323472583830059 1610 3246252
SGTC_1554 st069299 38.7 µM 0.456751610878431 0.330544041248958 no 1105 0.323924794964011 1547 24207999
SGTC_3239 9133757 49.47 µM 0.454472391045749 0.331378130539228 no 1106 0.324744429564928 1592 17036923
SGTC_1745 st081495 74 µM 0.453218527753568 0.331837343861264 no 1107 0.325195696149788 1574 13842402 YBL026W LSM2
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.452352090850889 0.332154814355526 no 1108 0.325507677515788 1538 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2680 butyl paraben 22.24 µM 0.451750560533766 0.332375291512804 no 1109 0.325724344857746 1571 7184 An antifungal and steroid mimetic.
SGTC_2871 9038510 12.99 µM 0.451351550848864 0.332521571382456 no 1110 0.325868098062461 1690 4945164
SGTC_2288 7946289 167.31 µM 0.451053725839588 0.332630772836631 no 1111 0.325975413836787 1681 1246052
SGTC_3179 9107801 49.47 µM 0.450450537109465 0.332851983418519 no 1112 0.326192805982496 1514 4818259
SGTC_1367 1812-0510 76.9 µM 0.448546090204 0.33355079288314 no 1113 0.326879565295787 1563 1142582 YDR527W RBA50
SGTC_2890 9046729 58.44 µM 0.447491835165546 0.333937885329843 no 1114 0.327259990888227 1481 903329
SGTC_918 glabranin 770.725 nM 0.444230477984941 0.335136480562295 no 1115 0.328437979535689 1608 124049 Also referred to as licorice root.
SGTC_871 0574-0004 149 µM 0.443103018067643 0.335551229715849 no 1116 0.328845611147082 1568 9551173
SGTC_1225 1216-0074 20.6 µM 0.442148700751663 0.335902443033548 no 1117 0.329190802477093 1537 4241466
SGTC_2115 tiliquinol 12.7705 µM 0.440771782784326 0.336409436826796 no 1118 0.329689111670247 1585 71208 A bioactive hydroxyquinoline.
SGTC_1403 3909-7815 62.9 µM 0.438917011815784 0.337092850808397 no 1119 0.330360834839137 1607 6615483
SGTC_3279 9140807 49.47 µM 0.43615648864191 0.338110996526556 no 1120 0.331361597353381 1562 45595718
SGTC_2882 9058044 58.44 µM 0.434083016184776 0.338876521764578 no 1121 0.332114079084262 1493 18076804
SGTC_988 1497-1057 103 µM 0.433338739552765 0.339151470997709 no 1122 0.332384349140716 1658 3533044
SGTC_1752 st044819 83.042 µM 0.432265126737975 0.339548233879288 no 1123 0.332774364988454 1513 441209 YML126C ERG13
SGTC_1507 4075-3230 155 µM 0.431059484847488 0.33999400129574 no 1124 0.333212559384144 1563 659771
SGTC_486 niguldipine 82 µM 0.430951351162999 0.340033992995706 no 1125 0.333251872056245 1598 1236 A calcium channel blocker.
SGTC_114 0364-0001 490.298 µM 0.430468413091789 0.340212622714069 no 1126 0.333427469546039 1505 4003655
SGTC_1966 st070145 16.1 µM 0.429631300585004 0.340522339849542 no 1127 0.333731932214901 1543 3748532
SGTC_2913 7966556 36.57 µM 0.428891085806301 0.340796296132674 no 1128 0.334001243861822 1675 2976516
SGTC_1784 st039334 36.3 µM 0.42857484443673 0.340913363871299 no 1129 0.334116327739715 1683 3496984
SGTC_684 1140-0066 328 µM 0.427909915013345 0.341159560576824 no 1130 0.334358354085868 1579 6813534
SGTC_864 0469-0573 172 µM 0.427293756208346 0.34138775985863 no 1131 0.334582689994252 1560 689425
SGTC_2334 9017922 200 µM 0.427165987140967 0.341435087406079 no 1132 0.334629216550793 1737 3163164
SGTC_339 3091-4833 71.4 µM 0.426665497240483 0.341620500257483 no 1133 0.334811492246501 1625 3240077
SGTC_1520 flindersine 88 µM 0.42631729145628 0.341749520069866 no 1134 0.334938329861575 1746 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1045 1348-1485 165 µM 0.426270535534677 0.341766845831979 no 1135 0.334955362631469 1553 6810614
SGTC_3159 9100096 49.47 µM 0.426136746186022 0.341816424333295 no 1136 0.335004102786673 1511 25236875
SGTC_2434 5670830 169.91 µM 0.426082881600928 0.341836385776415 no 1137 0.335023726719689 1586 1549830
SGTC_484 loperamide 105 µM 0.425707664675813 0.341975448056418 no 1138 0.335160438155412 1589 3955 An opioid-receptor agonist.
SGTC_971 1315-0384 26.7 µM 0.425654720348083 0.341995071922626 no 1139 0.335179730341907 1543 6769120
SGTC_2553 4-methylesculetin 85.09 µM 0.425406612993439 0.342087038839384 no 1140 0.335270143049179 1538 5319502
SGTC_2837 9008476 45.46 µM 0.424506331501516 0.342420828316489 no 1141 0.335598294394523 1622 2992805
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.423745102438822 0.342703158620609 no 1142 0.335875859202976 1545 688669
SGTC_2050 5263056 171 µM 0.423299936977302 0.342868305638461 no 1143 0.336038220135314 1704 763468 YGL055W OLE1
SGTC_2425 5628681 7.85 µM 0.423204345121187 0.342903772122786 no 1144 0.336073088428389 1680 5714958
SGTC_56 0957-0365 83.25 µM 0.420142873402047 0.3440403697965 no 1145 0.337190542093485 1566 6752360
SGTC_1446 4239-0190 62 µM 0.419813896791818 0.344162589299203 no 1146 0.337310706059768 1573 1340085
SGTC_185 k048-0037 25.491 µM 0.419783377958006 0.3441739283066 no 1147 0.337321854393145 1701 6827589
SGTC_760 0568-0725 82.9 µM 0.418655000502295 0.34459326541265 no 1148 0.337734143598855 1720 3916171
SGTC_1594 piperine 70.1 µM 0.416946716797205 0.34522847557606 no 1149 0.338358690889256 1562 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_995 3931-2021 34.6 µM 0.416835006943832 0.345270029111617 no 1150 0.338399547448851 1639 730143
SGTC_2120 5538279 151.968 µM 0.41544344364477 0.345787815348116 no 1151 0.338908654617791 1619 2058197
SGTC_2525 harmine 47.85 µM 0.414253807342056 0.346230695499591 no 1152 0.33934411971041 1671 5280953 A monoamine oxidase inhibitor
SGTC_2565 isoliquiritigenin 100 µM 0.412904363041912 0.346733323927587 no 1153 0.33983834216621 1516 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1184 1269-1718 139 µM 0.407533381901323 0.348736524163111 no 1154 0.341808140768133 1722 5403821
SGTC_2956 9076196 2.52 µM 0.406310854520432 0.349193079094742 no 1155 0.342257105451407 1631 16423868
SGTC_3295 9122362 53.5725 µM 0.405397614603043 0.349534272608808 no 1156 0.342592632049813 1608 4730473
SGTC_1216 1165-0504 9.65 µM 0.403276938513672 0.350327042262297 no 1157 0.343372252516694 1717 6304004
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.402826459054438 0.350495528571799 no 1158 0.343537947492723 1527 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_774 k060-0086 136 µM 0.402019444721792 0.350797437996197 no 1159 0.343834857995656 1797 5911235
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.401813328980789 0.350874562380259 no 1160 0.343910705965106 1665 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2947 9072639 7.68 µM 0.40166374203538 0.350930538668836 no 1161 0.3439657559913 1553 16488146
SGTC_2023 5144124 124 µM 0.400919294133122 0.351209163417526 no 1162 0.344239772095478 1604 2830192
SGTC_381 3461-2219 42.7 µM 0.400500486793826 0.351365945741472 no 1163 0.344393962503735 1727 2883159
SGTC_292 k038-0015 474 µM 0.398936438055597 0.35195167752344 no 1164 0.344970019748899 1656 46368540
SGTC_1039 k821-0043 94 µM 0.398195293107711 0.352229357020324 no 1165 0.345243117635607 1726 15992768
SGTC_697 0508-1955 564 µM 0.397374463609882 0.352536983319963 no 1166 0.345545671840186 1739 6243113
SGTC_2167 5876490 200 µM 0.393551871159295 0.353970862959978 no 1167 0.346955960263786 1801 686534
SGTC_3340 9146634 11.102 µM 0.392262497805952 0.354454984093786 no 1168 0.347432135051133 1623 4907387
SGTC_2685 mycophenolic acid 18.85 µM 0.391826623444732 0.354618695124601 no 1169 0.347593161081436 1693 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2111 5486399 200 µM 0.39083591831705 0.354990896146977 no 1170 0.347959261729447 1613 689674
SGTC_3030 9087619 49.47 µM 0.390657755027711 0.355057845550353 no 1171 0.348025114427898 1607 25236973
SGTC_1412 3909-8563 178 µM 0.390634259180223 0.355066675048793 no 1172 0.348033799302996 1750 23767530
SGTC_740 k014-0057 261 µM 0.390482081345634 0.355123863802045 no 1173 0.34809005140589 1756 4012779
SGTC_1862 st057513 3.81 µM 0.390477518444741 0.355125578600286 no 1174 0.348091738120825 1625 5393163
SGTC_2210 7115885 190.385 µM 0.390416217280158 0.355148616669653 no 1175 0.348114398906542 1653 2927039
SGTC_2329 6138490 200 µM 0.390155571502409 0.355246577905809 no 1176 0.34821075611784 1650 720019
SGTC_1671 st016596 74.5 µM 0.389963955097534 0.355318601210873 no 1177 0.348281600355999 1626 2829167
SGTC_400 oxethazaine 37.5 µM 0.388753662345329 0.355773636086787 no 1178 0.348729190889766 1619 4621 A local anesthetic.
SGTC_366 0181-0206 4.31 µM 0.388332864045525 0.35593189220646 no 1179 0.348884859919295 1814 274874
SGTC_742 0kpi-0133 140 µM 0.387296714424422 0.356321678792227 no 1180 0.349268278812604 1765 2728852
SGTC_2979 9012552 45.46 µM 0.386238691417094 0.356719848827945 no 1181 0.349659950578587 1680 17100905
SGTC_3102 9121669 49.47 µM 0.38547486761458 0.357007398798753 no 1182 0.349942811648069 1688 41905072
SGTC_1919 st067113 52.3 µM 0.384234924781517 0.357474362022162 no 1183 0.350402167562289 1619 1268243
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.383971866865801 0.357573457264578 no 1184 0.350499649584632 1741 165506
SGTC_2447 5741742 33.78 µM 0.380478326401669 0.35889039979993 no 1185 0.351795191016579 1731 1776504
SGTC_371 0195-0006 7.36 µM 0.380043736073281 0.359054342894518 no 1186 0.351956474897468 1575 3928593
SGTC_1876 myriocin 605 nM 0.379279270976944 0.359342789593185 no 1187 0.352240245560133 1763 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2442 5158906 48.48 µM 0.377563951114598 0.359990302811385 no 1188 0.352877274288968 1750 1893835
SGTC_2234 tolnaftate 200 µM 0.376599984369965 0.360354365548592 no 1189 0.35323544969419 1692 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2211 7117706 200 µM 0.374510853085526 0.361143805130677 no 1190 0.354012141775052 1740 822771
SGTC_709 3807-1509 243 µM 0.373852118191858 0.361392850321677 no 1191 0.354257170813287 1675 1886677 YPL242C IQG1
SGTC_12 0849-0099 9.267 µM 0.372254581928372 0.361997068084596 no 1192 0.354851655442255 1744 6071388
SGTC_457 grayanotoxin iii 135 µM 0.371946383168757 0.362113674198362 no 1193 0.354966384918546 1669 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1072 oxiconazole 14.9 nM 0.369076600164004 0.363200061444961 no 1194 0.356035314981287 1686 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_175 3793-3120 23.7 µM 0.368540874269793 0.363402988514659 no 1195 0.356234986608446 1659 5322297
SGTC_1700 st030840 7.9285 µM 0.368249749170559 0.363513279578372 no 1196 0.356343509049324 1794 5499307
SGTC_245 methotrexate 289.6 µM 0.368034673081627 0.363594767180503 no 1197 0.356423690242543 1715 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2446 5162541 200 µM 0.367247922281249 0.363892902316988 no 1198 0.356717048016569 1633 1549321
SGTC_315 k915-0449 187 µM 0.366262664749986 0.364266376762193 no 1199 0.357084543037173 1729 20970215 YNL149C PGA2
SGTC_2294 7971431 200 µM 0.363670394489247 0.365249624911638 no 1200 0.358052076740254 1706 5741572
SGTC_2138 5575593 77.673 µM 0.363232800990346 0.365415691756268 no 1201 0.35821549343082 1654 762213
SGTC_1781 st038725 66.3 µM 0.36263904904803 0.365641061114494 no 1202 0.358437268094479 1669 4270275 YIL048W NEO1
SGTC_982 1491-0518 27.5 µM 0.362073778815436 0.365855662825921 no 1203 0.358648448817576 1695 3091256
SGTC_2194 5927483 104.545 µM 0.361729588509323 0.365986353336421 no 1204 0.358777056914002 1714 760979
SGTC_1247 0448-0043 5.84 µM 0.361603816803374 0.366034113263801 no 1205 0.358824056014836 1684 3089013 YGL099W LSG1
SGTC_2862 9027634 71.43 µM 0.360403585227167 0.366489987611894 no 1206 0.359272672951495 1618 5012562
SGTC_726 3448-4391 34.2 µM 0.359703545014782 0.366755965329173 no 1207 0.359534420358626 1794 1356692
SGTC_2935 9038016 29.96 µM 0.35941210090965 0.366866717323409 no 1208 0.359643411737693 1783 6463195
SGTC_584 0986-0246 15.4 µM 0.358563543425369 0.367189241663286 no 1209 0.35996081184397 1729 53315 YDR232W HEM1
SGTC_2240 6690706 185.951 µM 0.357714946345443 0.367511874801392 no 1210 0.360278323355032 1595 805876
SGTC_2324 6149169 200 µM 0.357521541320884 0.367585419697032 no 1211 0.360350701372278 1762 2888231
SGTC_2854 9024559 71.43 µM 0.357410067789404 0.367627811232519 no 1212 0.360392420417418 1630 3163529
SGTC_2163 5671233 125 µM 0.357359858985128 0.367646905335036 no 1213 0.360411211639607 1790 701023
SGTC_2318 6029776 164 µM 0.356006315645684 0.36816177277204 no 1214 0.360917917722131 1752 818325
SGTC_669 0108-0021 26.2 µM 0.355796203158821 0.368241717651258 no 1215 0.360996596357633 1933 17201
SGTC_2919 7978188 46.38 µM 0.353418223069569 0.369146902934244 no 1216 0.361887463073878 1828 2980291
SGTC_3203 9113543 49.47 µM 0.352892782923621 0.369347011427548 no 1217 0.362084410798576 1746 17018012
SGTC_1550 gossypolone 36.6 µM 0.352627359123843 0.369448108823537 no 1218 0.362183911970614 1709 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1032 k061-1018 98.7 µM 0.35191048675646 0.369721203778001 no 1219 0.3624526971757 1846 4005393
SGTC_435 c-PAF 6.7 µM 0.351841427527586 0.369747515597915 no 1220 0.362478593930094 1752 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2644 guaiazulene 100 µM 0.351108172437227 0.370026926073519 no 1221 0.362753598531433 1772 3515 A coloring agent.
SGTC_1851 st056236 18.9 µM 0.34992779976148 0.370476856993054 no 1222 0.363196441609224 1829 5393171
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.349825446680304 0.370515879993058 no 1223 0.363234850273128 1805 16725076
SGTC_1300 1094-0077 113 µM 0.349450466235933 0.370658855919178 no 1224 0.363375575886165 1668 5532636
SGTC_1109 tnp00067 928.257 nM 0.349146983937629 0.370774583467944 no 1225 0.363489482615224 1676 676295
SGTC_2698 st077697 67.5 µM 0.348153451012988 0.371153531226954 no 1226 0.363862472068963 1632 3154499
SGTC_862 0452-0056 10.2 µM 0.347048892890648 0.371574972275347 no 1227 0.364277293764842 1739 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1631 benzylvanillin 81.9 µM 0.346663001207153 0.37172224448398 no 1228 0.364422254607413 1727 75506
SGTC_1475 4092-1048 11.7 µM 0.346509065711773 0.371780997868284 no 1229 0.364480086140388 1689 2881759
SGTC_2735 sertaconazole 140 nM 0.346477304675105 0.371793120644815 no 1230 0.364492018726418 1794 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_193 1273-0060 1.558 µM 0.345792405454584 0.372054568719843 no 1231 0.364749366528314 1780 2847393 YHR072W ERG7
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.345587632325375 0.372132748676111 no 1232 0.36482632095229 1675 6312947
SGTC_616 4092-0450 108 µM 0.345349785285434 0.372223562476806 no 1233 0.364915711498373 1749 787165
SGTC_217 ketoconazole 989 nM 0.344461473878178 0.372562796767104 no 1234 0.36524963230419 1725 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_660 4031-1742 102 µM 0.34429231242589 0.372627408487904 no 1235 0.365313232550386 1703 6738706
SGTC_3095 9117207 49.47 µM 0.343690348794128 0.372857359351213 no 1236 0.365539585038657 1844 17015229
SGTC_213 1246-0773 967 nM 0.343374593559865 0.372977996370144 no 1237 0.365658335166808 1745 6251622
SGTC_1996 st072960 66.8 µM 0.341182605359731 0.373815807219153 no 1238 0.366483058713392 1833 1719405
SGTC_633 0437-0093 97.7 µM 0.340735708305587 0.373986691332954 no 1239 0.366651277115942 1693 2831118
SGTC_745 0469-0705 296 µM 0.33993172531225 0.374294180004292 no 1240 0.366953972219489 1835 3486736
SGTC_2391 6285546 200 µM 0.339277289589593 0.374544532380673 no 1241 0.367200424703552 1674 846083
SGTC_2866 9034245 58.44 µM 0.338455701005695 0.374858903447837 no 1242 0.367509902377805 1848 6462273
SGTC_2955 9076254 12.21 µM 0.33831810934853 0.37491155938985 no 1243 0.367561739104619 1853 16459619
SGTC_1818 st052136 56.3 µM 0.336749710277946 0.37551194588566 no 1244 0.368152793163653 1663 674169
SGTC_1763 st044482 94.5 µM 0.33638227047234 0.375652646284992 no 1245 0.368291308720045 1792 88505
SGTC_784 4579-0127 173 µM 0.335970126193494 0.375810484641656 no 1246 0.368446697109587 1855 1948547
SGTC_3137 9097352 49.47 µM 0.335651383859905 0.375932567230089 no 1247 0.368566885457248 1791 44120435
SGTC_824 1304-0008 100 µM 0.334559029130942 0.376351047881022 no 1248 0.368978877740778 1729 768245
SGTC_1772 st048439 82.2 µM 0.333002350187683 0.376947662081269 no 1249 0.369566254557933 1725 2927068 YDL195W SEC31
SGTC_2045 5106652 78.05 µM 0.332723367662821 0.377054616279691 no 1250 0.369671554384009 1805 673349
SGTC_1830 st055982 50.3 µM 0.332514438609954 0.37713472008918 no 1251 0.369750419463051 1863 455313 An antimicrobial agent.
SGTC_346 4513-0042 7.16 µM 0.33239021988397 0.377182348299528 no 1252 0.369797311277188 1688 2827372
SGTC_1282 0886-0010 32.4 µM 0.332108881916783 0.377290226413418 no 1253 0.369903521807425 1875 2836211 YNL267W PIK1
SGTC_2807 7945238 51.95 µM 0.330899959663711 0.377753892548232 no 1254 0.370360026218969 1753 17148797
SGTC_3023 9089636 49.47 µM 0.330027797399906 0.378088508296306 no 1255 0.370689479231025 1815 17249241
SGTC_761 k216-0224 480 µM 0.329878087349534 0.378145955598323 no 1256 0.370746040667566 1909 1340404
SGTC_1078 idebenone 36.1 µM 0.328219619661276 0.378782529007946 no 1257 0.371372807232318 1743 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2155 5570423 76 µM 0.327622611699086 0.379011760545717 no 1258 0.371598511541191 1721 797402
SGTC_676 falcarinol 140 µM 0.327198491044623 0.379174634870867 no 1259 0.371758881053214 1862 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_257 daunorubicin 18.5 µM 0.325912704567733 0.379668544224422 no 1260 0.372245201606143 1866 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2495 cafestol 54.53 µM 0.324684736550575 0.380140427132416 no 1261 0.37270984389837 1792 16667697 An anti-infammatory.
SGTC_2154 5570129 200 µM 0.323844876559328 0.380463270912222 no 1262 0.373027739429062 1755 673366
SGTC_3259 9138485 49.47 µM 0.323604344454231 0.380555747261557 no 1263 0.373118799210224 1849 17646153
SGTC_2478 5763493 32.33 µM 0.321558062456017 0.38134274808976 no 1264 0.373893759477589 1800 1365576 YLR208W SEC13
SGTC_2686 alizarin 95.37 µM 0.321454619841055 0.381382545221068 no 1265 0.373932948447086 1685 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1314 1222-0010 41.1 µM 0.319534227738336 0.382121598616254 no 1266 0.374660720332887 1777 3526027
SGTC_2127 5253358 187.912 µM 0.318722191816166 0.382434236049249 no 1267 0.374968592487165 1709 20612
SGTC_848 0368-0089 85.6 µM 0.315089716962461 0.383833690605538 no 1268 0.376346767919827 1839 762535
SGTC_2719 novobiocin 32.65 µM 0.313503660629898 0.384445214543168 no 1269 0.376949019995634 1853 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1870 st057514 26.5 µM 0.313478747657817 0.384454822351292 no 1270 0.376958482260167 1738 5393161
SGTC_2257 7960413 200 µM 0.308915951249412 0.386215678132026 no 1271 0.378692731268052 1830 2974689 YIL048W NEO1
SGTC_3296 9122258 64.045 µM 0.30840001021012 0.386414936314967 no 1272 0.378888987100606 1777 4730474
SGTC_2164 5685496 200 µM 0.305845968081165 0.387401756295619 no 1273 0.379860963464463 1855 759046
SGTC_1436 4092-1007 8.32 µM 0.305061326773643 0.387705069155832 no 1274 0.380159722443586 1784 2881121
SGTC_1037 k284-1091 78.7 µM 0.304493010540526 0.387924801678304 no 1275 0.380376158446579 1735 3334711
SGTC_3034 9090421 49.47 µM 0.303828701300195 0.388181694215391 no 1276 0.380629199641544 1890 17173761
SGTC_3220 9131269 49.47 µM 0.303803546396632 0.388191422736112 no 1277 0.380638782368462 1775 17722206
SGTC_1466 k213-0079 57.5 µM 0.301557517334313 0.389060344243771 no 1278 0.381494698674874 1772 3657981
SGTC_3031 9088762 49.47 µM 0.301279680432918 0.38916786970798 no 1279 0.381600617090502 1753 205253
SGTC_2418 pentamidine 31.67 µM 0.300316417190833 0.389540727218386 no 1280 0.381967905879367 1745 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1455 4262-0120 131 µM 0.298133956243194 0.390385884458488 no 1281 0.382800462992665 1862 1529587
SGTC_1620 st003704 16.5 µM 0.296209478391084 0.391131567983598 no 1282 0.383535055383869 1911 2834414
SGTC_807 1315-0151 48 µM 0.296005735835667 0.391210536241587 no 1283 0.383612850512976 1929 4011080
SGTC_3266 9136860 49.47 µM 0.295901721000223 0.391250852918222 no 1284 0.383652568362593 1775 4871271 YPR165W RHO1
SGTC_904 1141-0088 396 µM 0.295802969544892 0.391289130563387 no 1285 0.383690277532652 1729 1378119
SGTC_598 3937-0236 20.2 µM 0.295060621119579 0.391576910380678 no 1286 0.383973785487396 1851 1379313
SGTC_275 trichlorophene 5.69 µM 0.293838336076223 0.392050872327991 no 1287 0.384440719774278 1816 62616
SGTC_1016 4226-1401 38 µM 0.293519984025079 0.392174345113011 no 1288 0.384562363390092 1773 2901613
SGTC_1469 k284-2957 126 µM 0.293246882723223 0.392280276056016 no 1289 0.384666725569112 1836 23884841
SGTC_2551 apiole 73.87 µM 0.292524307389602 0.392560588144122 no 1290 0.38494288881005 1838 10659 A possible DNA adduct former.
SGTC_3339 9145883 14.936 µM 0.291009234806314 0.393148518281684 no 1291 0.38552212833625 1880 2030670
SGTC_2172 5754775 163.918 µM 0.288367426310776 0.394174265365107 no 1292 0.386532749600418 1748 2263357
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.288300799769733 0.394200144281686 no 1293 0.386558247503038 1850 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_610 4215-0184 155 µM 0.287964135446254 0.394330917747881 no 1294 0.386687096050533 1818 5605015
SGTC_2343 7990716 14.84 µM 0.287704106187106 0.394431931340152 no 1295 0.386786623291328 1839 6456862
SGTC_409 arachidonic acid 100 µM 0.287193639715346 0.394630252944571 no 1296 0.386982028029471 1815 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1034 k072-0165 12.7 µM 0.285795953087754 0.395173408554865 no 1297 0.387517203940174 1933 5835461
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.285605767619521 0.3952473323838 no 1298 0.38759004273573 1738 4330530
SGTC_1096 rimcazole 32.2 µM 0.284398125236537 0.395716822829611 no 1299 0.388052647778339 1797 18528119 A dopamine reuptake inhibitor.
SGTC_1665 st014639 11.4 µM 0.284023256750059 0.395862589812054 no 1300 0.388196278972809 1858 981133 YIL048W NEO1
SGTC_2327 6189656 200 µM 0.282057574916665 0.396627179875998 no 1301 0.38894968163839 1905 5349088
SGTC_1740 st038286 13.222 µM 0.281950120290986 0.396668987925549 no 1302 0.38899087870492 1838 716786
SGTC_930 2810-3379 265 µM 0.281423112009389 0.396874051556172 no 1303 0.389192946658422 1951 1015764
SGTC_349 k015-0014 24 µM 0.280804699230055 0.397114717858565 no 1304 0.389430099563064 1765 2196908
SGTC_1380 2291-0730 164 µM 0.280267331499256 0.397323875863528 no 1305 0.389636206238203 1773 2999191
SGTC_444 curcumin 90.4 µM 0.279477707650408 0.397631272308241 no 1306 0.389939121717571 1858 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1215 3852-0577 11.2 µM 0.279391819272005 0.397664712042952 no 1307 0.389972074249537 1917 2884876
SGTC_2960 9079389 5.97 µM 0.279308972180708 0.397696968397093 no 1308 0.390003860689415 1930 16457355
SGTC_1050 3232-1156 69.3 µM 0.279014911110559 0.397811466149703 no 1309 0.390116690799408 1770 700529
SGTC_934 2950-0684 338 µM 0.278551574431915 0.397991892140098 no 1310 0.390294490096169 1927 1121253
SGTC_1964 st076914 61 µM 0.277018347971215 0.398589094763564 no 1311 0.390883008810299 1853 24208661
SGTC_1379 2144-0755 36.5 µM 0.275999677525977 0.398986005590034 no 1312 0.391274156957273 1946 5392327
SGTC_914 3820-6779 408 µM 0.27416399923699 0.399701515704656 no 1313 0.391979296460443 1783 2893481
SGTC_535 2293-4129 48.2 µM 0.273292720795009 0.400041240410688 no 1314 0.392314105198152 1939 396118 YIL048W NEO1
SGTC_2073 5212005 126 µM 0.273255139792654 0.400055895518659 no 1315 0.392328548356222 1966 691789
SGTC_699 0375-0592 111 µM 0.272391832938573 0.400392589841109 no 1316 0.392660375872723 1992 762578
SGTC_300 r073-0011 5.04 µM 0.27218011371618 0.400475172792312 no 1317 0.392741765888859 1929 2735780
SGTC_3116 9124943 49.47 µM 0.271013238626968 0.400930402461705 no 1318 0.393190425110506 1723 41905195 YPL160W CDC60
SGTC_1456 k015-0012 13 µM 0.271000370894773 0.400935423264786 no 1319 0.393195373498769 2002 2989616
SGTC_711 k292-0785 179 µM 0.267654714949078 0.402241402726314 no 1320 0.394482555254863 1811 4146315
SGTC_2606 farnesol 9.78 µM 0.267484848837849 0.402307739350053 no 1321 0.394547939100368 1928 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1802 st050112 57.9 µM 0.267464038575218 0.402315866429793 no 1322 0.394555949466253 1904 4662563
SGTC_744 1594-0068 283 µM 0.267301121402223 0.402379492307134 no 1323 0.394618661708156 1809 668392
SGTC_821 1114-0266 29.2 µM 0.265429187517854 0.403110744895139 no 1324 0.395339426941448 1812 3123235
SGTC_3183 9108214 49.47 µM 0.265100708577623 0.403239096998836 no 1325 0.395465940747792 1937 4974831
SGTC_46 0329-0187a 2.197 µM 0.264757415697281 0.403373248743316 no 1326 0.395598171923195 1883 46494817
SGTC_1182 1222-0449 220 µM 0.264452118393892 0.40349256215728 no 1327 0.395715777880185 1861 658318
SGTC_2415 st077333 57.7 µM 0.264144199828182 0.403612909087172 no 1328 0.395834403212181 2036 2766255
SGTC_2140 5586273 200 µM 0.264125212108667 0.403620330548659 no 1329 0.395841718528853 1852 854421
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.263150500155097 0.40400134898656 no 1330 0.396217290817411 1926 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.262748720141398 0.404158432786487 no 1331 0.39637213121927 1804 2333 A French combination drug.
SGTC_2990 9074105 71.4286 µM 0.261190315765952 0.404767867641045 no 1332 0.396972872943575 1872 6502001
SGTC_951 1171-0579 82.7 µM 0.261135969179473 0.404789124778111 no 1333 0.396993827166099 1799 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1828 st055811 49 µM 0.259920802870442 0.405264498491689 no 1334 0.397462432128448 1978 5877589
SGTC_1256 0570-0116 285 µM 0.258150251323669 0.405957389273848 no 1335 0.398145475273961 1770 410638
SGTC_1863 st057641 20.1 µM 0.258131327928495 0.405964796384344 no 1336 0.398152777229028 2006 3921635
SGTC_2302 7771753 200 µM 0.258023115205354 0.406007154313521 no 1337 0.398194533869372 1768 2203047
SGTC_3187 9109394 49.47 µM 0.257794324779766 0.406096713843062 no 1338 0.398282822330697 1793 17098090
SGTC_1464 k208-0027 110 µM 0.256516185363824 0.406597129102041 no 1339 0.398776142162016 1948 X1464
SGTC_2358 9037157 4 µM 0.25647281195479 0.406614113276286 no 1340 0.398792885715391 1877 2388925
SGTC_3257 9139206 32.98 µM 0.255812908473114 0.40687254015647 no 1341 0.39904765298287 1937 4910041
SGTC_3131 9127911 49.47 µM 0.254411577417603 0.407421454192433 no 1342 0.399588803835272 1887 45595681
SGTC_3229 9132204 49.47 µM 0.253645816091546 0.407721486725314 no 1343 0.399884598848328 1902 17682924
SGTC_1842 st055362 61.2 µM 0.253267596605623 0.407869696680051 no 1344 0.400030717063628 1909 676032
SGTC_1330 1469-0054 61.8 µM 0.253070099823023 0.407947093463328 no 1345 0.400107021915524 1992 7102664
SGTC_1557 sumaresinolic acid 42.3 µM 0.252806196118478 0.408050519984208 no 1346 0.400208989696625 1821 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3346 9158254 43.5805 µM 0.250137694955643 0.409096691236944 no 1347 0.401240432984441 1863 17639500
SGTC_351 caspofungin 25 nM 0.249826470907109 0.409218747246459 no 1348 0.401360773939755 1894 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_713 1488-1073 324 µM 0.248153067569157 0.409875174048193 no 1349 0.402007988694521 1988 3312542
SGTC_2267 7931562 200 µM 0.247412114772465 0.410165908807553 no 1350 0.402294649673662 1736 934880
SGTC_2908 7930301 100 µM 0.247097622068692 0.410289324266218 no 1351 0.402416336999799 1855 2223178
SGTC_3249 9135183 49.47 µM 0.246828095401946 0.41039510090451 no 1352 0.402520633047902 1914 4902779
SGTC_1948 st076329 66.6 µM 0.244798511691296 0.411191826634942 no 1353 0.403306223181419 1963 24208413
SGTC_554 4483-2211 187 µM 0.244474661507674 0.411318990026875 no 1354 0.403431611935721 1875 747107
SGTC_1958 st076513 41.9 µM 0.243051724488638 0.411877832378431 no 1355 0.403982664100801 1854 732122 YGL099W LSG1
SGTC_439 amiodarone 34.4 µM 0.242492024290592 0.412097697326998 no 1356 0.404199468084145 1937 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2107 5363541 170.161 µM 0.240495074628198 0.412882376039979 no 1357 0.404973240558503 1939 244052
SGTC_2583 asiatic acid 100 µM 0.240327587576211 0.412948204047553 no 1358 0.405038154908481 1905 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3054 9094397 49.47 µM 0.239715359574826 0.413188850922711 no 1359 0.405275463427505 1840 2598354
SGTC_652 0437-0092 114 µM 0.239097664958264 0.413431679604845 no 1360 0.405514926184144 1843 3091274
SGTC_3322 9139058 2.11 µM 0.237685177974781 0.413987082102323 no 1361 0.406062640265381 1957 4908926 YPR165W RHO1
SGTC_2378 9074213 121.43 µM 0.237003010225355 0.414255378245882 no 1362 0.406327227480697 1880 657714
SGTC_1193 1488-0126 41.5 µM 0.236879607194537 0.414303916857605 no 1363 0.406375095448324 1851 1384710
SGTC_2870 9038528 12.99 µM 0.235554358642084 0.414825264570004 no 1364 0.406889246693648 1895 6463316
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.235269757805645 0.414937245054125 no 1365 0.406999683080399 1983 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2699 st077704 54.6 µM 0.235109331721448 0.415000370159046 no 1366 0.407061938009011 1894 645852
SGTC_2514 salinomycin 42.74 µM 0.234364457592321 0.415293494971728 no 1367 0.407351024520204 2025 23682228 A polyether potassium ionophore.
SGTC_2937 9044753 11.33 µM 0.234217550632952 0.415351311754028 no 1368 0.407408045244482 1896 6465530 YGL099W LSG1
SGTC_286 k060-0067 22.9 µM 0.233123262957313 0.41578203779783 no 1369 0.407832845637944 1905 5985051
SGTC_1147 3809-1045 12.3 µM 0.2317518459504 0.416321988424834 no 1370 0.408365380082556 1874 325925
SGTC_2376 9072922 81.32 µM 0.231025201023581 0.416608145200116 no 1371 0.408647611981876 1937 17087968
SGTC_2629 bisabolol 100 µM 0.230146366041516 0.41695429429734 no 1372 0.408989018424335 1938 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1547 harmine 94.2 µM 0.229383443882809 0.417254840720451 no 1373 0.409285451504618 1906 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_288 1315-0019 35.1 µM 0.228472865482333 0.417613618295969 no 1374 0.409639324255091 1912 6811474
SGTC_1236 0330-0013 258 µM 0.227056250183725 0.418171916051221 no 1375 0.410190001432977 1880 4617066
SGTC_3025 9087895 49.47 µM 0.22701072419619 0.418189860894686 no 1376 0.41020770157533 2016 17173641
SGTC_1201 1889-3372 45.9 µM 0.226256326689829 0.418487244286584 no 1377 0.410501031938362 1889 5392199
SGTC_1422 4031-0024 15.5 µM 0.225358119668627 0.418841378123049 no 1378 0.410850344656486 2003 782427
SGTC_1883 5-benzylidenerhodanine 20 µM 0.225344891276829 0.418846594140192 no 1379 0.410855489707218 2015 1273210
SGTC_1640 st009078 66.4 µM 0.22526561827727 0.418877852155874 no 1380 0.410886322469144 1991 690618
SGTC_1396 3511-0007 98.6 µM 0.225125328051341 0.418933171036129 no 1381 0.41094088886783 1904 X1396
SGTC_2812 7970281 58.44 µM 0.225089922461548 0.418947132330377 no 1382 0.410954660274424 1984 2233435
SGTC_1638 st008370 60.6 µM 0.223535792530663 0.419560064295103 no 1383 0.411559264686748 1955 24207134
SGTC_822 1487-0950 154 µM 0.222829044478746 0.419838862714324 no 1384 0.411834281020463 2023 1958375
SGTC_2638 epoxomicin 18 µM 0.221637677360678 0.420308924982404 no 1385 0.412297974784312 2024 9915668 A protesome inhibitor.
SGTC_515 4092-1064 102 µM 0.221166757276281 0.420494761197181 no 1386 0.412481296092283 2042 717353
SGTC_139 0099-0334 718.624 µM 0.220412430487061 0.420792473321039 no 1387 0.412774982660286 2068 97690
SGTC_1180 1193-0155 285 µM 0.219759810059703 0.421050081290976 no 1388 0.413029110687684 1903 2921347
SGTC_2941 9056145 11.23 µM 0.219420377781485 0.421184078301017 no 1389 0.413161298801083 2043 2119517
SGTC_2482 5981709 142.65 µM 0.218274836896265 0.42163636852369 no 1390 0.413607489515046 1948 877755
SGTC_2601 securinine 100 µM 0.216768985389524 0.42223107624251 no 1391 0.414194191669608 1888 442872 A GABA receptor antagonist.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.216675578759903 0.422267971288967 no 1392 0.414230590604622 1895 229346 A bile salt which induces apoptosis.
SGTC_1369 1866-0067 208 µM 0.216327930786688 0.422405296099779 no 1393 0.414366069429434 2022 3531355
SGTC_2541 muurolladie-3-one 83.07 µM 0.215625330503943 0.422682859793486 no 1394 0.41463990467636 1957 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1432 4049-0298 68.4 µM 0.215149476722388 0.422870868628052 no 1395 0.414825390084459 2045 741646
SGTC_1365 1672-3266 55.4 µM 0.214740868674949 0.423032322835458 no 1396 0.414984678600451 2032 6415873
SGTC_846 0335-0850 148 µM 0.214591084948463 0.423091510452221 no 1397 0.415043072601064 2002 6819598
SGTC_3320 9137005 35.139 µM 0.214438503814774 0.423151805260017 no 1398 0.415102559115941 1885 4908713
SGTC_158 k038-0087 26.446 µM 0.214328411018869 0.42319531125837 no 1399 0.415145481992726 1909 X158
SGTC_334 1502-1024 68.5 µM 0.213202625378509 0.423640248057284 no 1400 0.415584460294737 1954 3296216
SGTC_2253 7938677 135.83 µM 0.212850572466655 0.423779407610522 no 1401 0.41572175816183 2059 2301972
SGTC_733 4069-0007 56.1 µM 0.211883512000015 0.424161716356429 no 1402 0.416098957038585 1975 5717425 YNL287W SEC21
SGTC_198 3454-2873 16.191 µM 0.21066018625762 0.424645436859057 no 1403 0.416576222069684 1935 710957
SGTC_1338 1486-1223 76 µM 0.20975885923306 0.42500190712599 no 1404 0.416927942125008 2004 3444526
SGTC_1912 st060209 90.8 µM 0.20822203666746 0.425609853947672 no 1405 0.41752780144669 1876 688787
SGTC_488 nitrendipine 139 µM 0.208028080670463 0.42568659299367 no 1406 0.417603520873694 2000 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1925 st057770 10.1 µM 0.206929432723261 0.426121328116242 no 1407 0.418032484987786 1798 5989122
SGTC_1985 st071382 65.5 µM 0.206421304947901 0.426322424739199 no 1408 0.418230915117085 1935 6123237
SGTC_716 1683-5115 658 µM 0.206245774934291 0.426391896943282 no 1409 0.418299466580007 2062 723597
SGTC_393 acivicin 6.25 µM 0.204979641597784 0.426893081470124 no 1410 0.418794015477157 1943 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3302 9125395 16.351 µM 0.204412976556416 0.427117427689351 no 1411 0.419015395223841 1946 17599668
SGTC_2667 digitoxin 100 µM 0.201647210055894 0.428212748891171 no 1412 0.420096267484312 2070 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_892 0929-0076 29 µM 0.199133333976114 0.42920879468384 no 1413 0.421079223308528 1906 5751038
SGTC_1279 0874-0590 65.2 µM 0.199104114108573 0.429220374817582 no 1414 0.421090651533918 1986 3523074
SGTC_3198 9112019 49.47 µM 0.197397721612164 0.42989674102324 no 1415 0.421758156217498 1970 45595555
SGTC_2607 solasodine 47.35 µM 0.196737925791301 0.430158320889941 no 1416 0.422016314788038 1912 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3317 9138495 8.753 µM 0.196183212963939 0.430378263722215 no 1417 0.422233383430551 2073 17020139
SGTC_2041 5107442 45.335 µM 0.194400272671742 0.431085342929514 no 1418 0.42293123821577 2045 793005
SGTC_2481 5478948 45.16 µM 0.193853377281794 0.431302275315448 no 1419 0.423145345321442 1936 77792
SGTC_1420 4'-methoxyflavone 42 µM 0.192666591190866 0.431773098950155 no 1420 0.42361004477867 2066 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2016 5121758 140 µM 0.19110188114426 0.432394001216603 no 1421 0.424222886929816 2046 2795203
SGTC_1198 1612-1005 86.7 µM 0.189765320206562 0.432924502533656 no 1422 0.424746516258739 2055 6998509
SGTC_1497 4476-2978 41.3 µM 0.189402532617732 0.433068519336094 no 1423 0.42488866982662 2026 1528379
SGTC_441 propafenone 146 µM 0.188607018144949 0.433384348030898 no 1424 0.425200415928266 2001 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2815 7968870 71.43 µM 0.187353822200775 0.433881967934225 no 1425 0.425691612995983 1960 2977326 YHR190W ERG9
SGTC_965 1291-5240 308 µM 0.187012891011968 0.434017363292118 no 1426 0.425825262846242 2048 2834598
SGTC_3245 9134821 49.47 µM 0.186933967729762 0.434048707512896 no 1427 0.425856203104873 1926 17014901
SGTC_1767 st044992 70.3 µM 0.186695860768992 0.434143273719287 no 1428 0.425949550834269 1946 9600693
SGTC_2675 theaflavin digallate 100 µM 0.185789526756236 0.434503266419781 no 1429 0.426304908989502 2007 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_544 k015-0020 52.4 µM 0.185332357709713 0.434684872993428 no 1430 0.426484179922576 1955 3008304
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.18488738664628 0.434861647256271 no 1431 0.426658682215321 1981 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2805 7950783 58.44 µM 0.18438317689429 0.435061971089644 no 1432 0.426856433226292 1991 1178958 YDL195W SEC31
SGTC_890 0929-0006 47.2 µM 0.182881017547505 0.435658881478135 no 1433 0.427445688751714 1914 1378169
SGTC_3010 9080089 71.4286 µM 0.182831060797814 0.435678735229415 no 1434 0.427465288190375 2071 17027233
SGTC_1104 tacrolimus 29.8 µM 0.182810498220386 0.435686907231263 no 1435 0.42747335552013 1992 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_525 k781-2675 26.7 µM 0.182507864736738 0.435807183333427 no 1436 0.427592091423002 2119 3651118 YDL195W SEC31
SGTC_390 dec-rvkr-cmk 16.7 µM 0.182027553762358 0.435998086265985 no 1437 0.427780551172959 2008 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2078 5212016 200 µM 0.182001531711652 0.436008429336998 no 1438 0.427790761923119 2129 1899708
SGTC_2976 9009005 19.48 µM 0.17889224084838 0.437244602561458 no 1439 0.429011157707617 2113 2993148
SGTC_1004 4084-0029 199 µM 0.176328575102861 0.438264310990895 no 1440 0.430017907021439 2102 716894 YLR208W SEC13
SGTC_3081 9117243 49.47 µM 0.175987102599477 0.438400164152536 no 1441 0.430152037470732 2091 45595589
SGTC_2284 7945075 39.21 µM 0.175962038676876 0.438410135997434 no 1442 0.430161882900923 2117 1245402
SGTC_1014 4130-3005 69.3 µM 0.175899609123668 0.438434974171886 no 1443 0.430186406218717 1931 743608
SGTC_2457 5731572 11.68 µM 0.174424665295458 0.439021864530178 no 1444 0.430765865663525 2108 2865357
SGTC_2878 9043973 25.97 µM 0.174042599912604 0.439173912906871 no 1445 0.430915991602469 2086 6465167
SGTC_47 0149-0135 24.25 µM 0.173830990261391 0.439258129853762 no 1446 0.430999144227107 1914 5239155
SGTC_969 1313-0238 134 µM 0.173471307003065 0.439401283817627 no 1447 0.431140489820292 1974 5212874
SGTC_410 α-linolenic acid 100 µM 0.173442498109756 0.439412750102376 no 1448 0.431151811301955 2062 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_589 1227-0070 34.1 µM 0.173140683799067 0.439532878868627 no 1449 0.431270423394055 2024 2841384
SGTC_1840 st055363 71 µM 0.171586520360992 0.440151558188404 no 1450 0.431881302734823 1932 676033
SGTC_1832 st054113 55 µM 0.170112031205896 0.440738656011805 no 1451 0.43246101594416 2112 1251267
SGTC_135 0933-0004 26.348 µM 0.16855314083724 0.441359501554859 no 1452 0.433074070635497 1956 21230617 YGL099W LSG1
SGTC_2088 5278280 127.392 µM 0.166573528580796 0.442148111827387 no 1453 0.433852811895522 2028 791502
SGTC_2316 5844804 197.44 µM 0.166235910499706 0.442282630378505 no 1454 0.433985650051629 2132 776813
SGTC_1352 1496-0991 99 µM 0.165894524417845 0.442418656996715 no 1455 0.434119978334428 2006 3000039
SGTC_3129 9127257 49.47 µM 0.164736939075605 0.442879951844648 no 1456 0.434575520498938 1867 837894
SGTC_1376 2910-0861 41.3 µM 0.164260369871685 0.443069886012947 no 1457 0.434763089071767 2072 1112859
SGTC_1587 estradiol valerate 56.1 µM 0.164221476815316 0.443085387215508 no 1458 0.434778397287518 2119 13791 A steroid.
SGTC_1860 st056228 74.6 µM 0.163516492183174 0.443366380713754 no 1459 0.435055894511314 1988 688679
SGTC_172 1112-0046 2.638 µM 0.162004936042207 0.443968954133169 no 1460 0.435650983410731 2009 2802135 YIL048W NEO1
SGTC_2611 pyromycin 23.93 µM 0.161788869439363 0.444055098494033 no 1461 0.435736059231505 1976 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_634 1611-4317 11.2 µM 0.161688233818027 0.444095222169642 no 1462 0.435775685334619 2147 2843522
SGTC_2245 6637752 200 µM 0.161211082043646 0.444285471575756 no 1463 0.435963576537475 2122 681890
SGTC_132 0417-1715 25.805 µM 0.160999688262411 0.444369762367208 no 1464 0.436046823084295 2150 6769098
SGTC_2781 5567276 71.43 µM 0.160211161755422 0.444684200232447 no 1465 0.43635736857952 2068 2853274
SGTC_21 0849-0113 22.993 µM 0.160084797762412 0.444734593186821 no 1466 0.436407138179434 2024 1560156
SGTC_244 nsc-207895 1.295 µM 0.159536605036604 0.444953218414099 no 1467 0.436623060483376 2015 42640
SGTC_415 dibenzyl ketone 100 µM 0.159022554236154 0.445158242684433 no 1468 0.436825552114509 2106 7593
SGTC_148 3253-0744 288.01 µM 0.158752093015593 0.445266119461917 no 1469 0.436932097132392 2161 6893655
SGTC_577 r071-0003 38.6 µM 0.158566032224378 0.445340334445941 no 1470 0.437005396250028 2082 4568517 YMR134W ERG29
SGTC_861 0443-0273 110 µM 0.157798899560677 0.44564634463208 no 1471 0.437307632908389 2067 6149169
SGTC_2602 kawain 100 µM 0.157631289686659 0.445713208739012 no 1472 0.43737367310133 2161 5369129
SGTC_2998 9066762 71.4286 µM 0.156823180708851 0.446035606877224 no 1473 0.437692101665477 2098 4945196
SGTC_304 1310-0298 97 µM 0.156300649103149 0.446244091849704 no 1474 0.437898022358737 2032 1550234
SGTC_41 0478-0632 82.643 µM 0.154556421269918 0.44694012888612 no 1475 0.438585513925251 2175 3750424
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.153956582456321 0.447179533453175 no 1476 0.43882198476309 1993 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2701 st077767 14.721 µM 0.153911552369462 0.447197506406492 no 1477 0.438839737584951 2015 5721188
SGTC_920 mycophenolic acid 780.421 nM 0.153779746028297 0.447250115171878 no 1478 0.438891702093474 2000 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_137 0438-0332 85.389 µM 0.153495234770889 0.447363677256488 no 1479 0.43900387394076 2114 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1178 0988-0033 191 µM 0.151399948390788 0.44820013882864 no 1480 0.439830115085742 2072 5392207
SGTC_1444 4112-3581 28 µM 0.151263388092063 0.44825466325144 no 1481 0.439883974493702 2047 2877249
SGTC_3173 9105693 49.47 µM 0.15099173209024 0.448363130233518 no 1482 0.439991118979783 2091 17096658
SGTC_1563 conessine 56.1 µM 0.150978842986117 0.448368276699241 no 1483 0.43999620271109 2133 441082 An anti-amoebic, histamine inhibitor.
SGTC_677 0929-0063 136 µM 0.150792169215681 0.448442814285683 no 1484 0.440069831845667 2152 1539583
SGTC_2372 9071633 200 µM 0.150751758118329 0.448458950405979 no 1485 0.440085771337748 2169 21321366
SGTC_2408 sulbentine 18.36 µM 0.150044864418518 0.448741226288264 no 1486 0.440364609603516 2031 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2855 9016525 58.44 µM 0.149839277529735 0.448823325857366 no 1487 0.440445710086278 2103 43811474
SGTC_3208 9114115 49.47 µM 0.149645317037757 0.44890078452197 no 1488 0.440522226446432 1923 650895
SGTC_571 k831-0106 44.2 µM 0.145676866866416 0.450486019622134 no 1489 0.442088242046581 2173 4783639
SGTC_2060 5238662 140 µM 0.143644243735837 0.451298277869155 no 1490 0.442890700739401 2035 790130
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.142355079059469 0.45181354797232 no 1491 0.443399771332795 2031 5282362
SGTC_1716 st033144 30.6155 µM 0.142256518866112 0.451852945143803 no 1492 0.443438695038174 2160 674617
SGTC_3231 9132313 49.47 µM 0.142186685533937 0.451880859699952 no 1493 0.443466274170418 2066 4905967
SGTC_149 3970-0822 46.1 µM 0.141752997179015 0.452054223753308 no 1494 0.443637555934072 2124 3114250 YBL034C STU1
SGTC_3086 9117350 49.47 µM 0.141435885167474 0.452180992972389 no 1495 0.44376280346542 2162 2679265
SGTC_901 1112-0062 60.1 µM 0.140300019273033 0.452635108506209 no 1496 0.444211474548887 2118 1908457
SGTC_2300 7976697 71.57 µM 0.140185745671811 0.452680798164886 no 1497 0.444256616997596 2018 2236109
SGTC_416 estradiol valerate 100 µM 0.137595901228082 0.453716454463165 no 1498 0.445279897531297 2060 13791 A steroid.
SGTC_929 2805-0021 398 µM 0.137004035628816 0.453953180824294 no 1499 0.445513802611441 2066 3098024
SGTC_2251 lansoprazole 556 µM 0.135650362185881 0.454494666099143 no 1500 0.446048845058555 1964 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2850 9015429 58.44 µM 0.134592522620844 0.454917873272319 no 1501 0.446467026947958 2084 6457570
SGTC_350 k064-0020 19.8 µM 0.134223922590648 0.455065350191825 no 1502 0.446612754792437 2175 2790705
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.13408093784503 0.45512256007523 no 1503 0.446669286460582 2207 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3047 9092122 49.47 µM 0.133342963212756 0.455417847203681 no 1504 0.446961075610481 2055 17173831
SGTC_1710 st031758 61.5 µM 0.131338553975307 0.456219998948863 no 1505 0.447753747133997 2172 5394341
SGTC_958 1222-0007 33 µM 0.131085710959493 0.45632119784862 no 1506 0.447853752311294 2133 7312461
SGTC_1891 st059073 26.2 µM 0.13019229108852 0.456678806440217 no 1507 0.448207146745486 2202 688754
SGTC_100 0086-0128 49.5915 µM 0.129959332322972 0.456772058473171 no 1508 0.448299300928092 1970 93297
SGTC_1694 st024011 44.9 µM 0.129499967430452 0.456955946526605 no 1509 0.448481025360893 2177 2787533
SGTC_3241 9133421 49.47 µM 0.129271353904669 0.45704746609199 no 1510 0.448571468744331 2178 17018221
SGTC_2888 9058547 12.99 µM 0.129027443274666 0.457145111972715 no 1511 0.448667966868405 2095 16476514
SGTC_203 k066-0004 30.888 µM 0.128678424197932 0.457284840906963 no 1512 0.448806054225094 2190 6795412
SGTC_2175 5807670 165.306 µM 0.127274734569831 0.457846857769589 no 1513 0.449361478277921 2170 241186
SGTC_1269 0831-0796 3.05 µM 0.126509825838505 0.458153151629338 no 1514 0.4496641858221 2166 927758
SGTC_328 k915-0120 63.5 µM 0.126107000984396 0.458314465554063 no 1515 0.449823612866353 2175 6624543
SGTC_1726 st035556 14.5795 µM 0.124470254504676 0.45896998204854 no 1516 0.450471475334524 2172 5919439
SGTC_1583 clindamycin 39.6 µM 0.122560894739067 0.459734820968949 no 1517 0.451227411195211 2000 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3090 9117696 49.47 µM 0.120682455747802 0.460487419297329 no 1518 0.451971277851329 2184 7923821
SGTC_2475 5812728 15.03 µM 0.120203975992502 0.460679145385861 no 1519 0.452160784114421 2208 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1355 1499-0035 1.68 µM 0.119917268235647 0.460794033117645 no 1520 0.452274342556786 2108 1548538
SGTC_447 ml7 120 µM 0.118849349187232 0.461221991652869 no 1521 0.452697355362455 2215 4216 Selective myosin light chain kinase inhibitor.
SGTC_2193 5925765 200 µM 0.118625787127965 0.461311587751305 no 1522 0.452785917214875 2164 877370
SGTC_1779 st039427 55 µM 0.117061981892602 0.461938362560728 no 1523 0.453405468299848 2229 1124498
SGTC_255 tunicamycin 200.472 nM 0.117011487247172 0.461958602452447 no 1524 0.453425475254939 2191 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1056 3448-1962 115 µM 0.116858717253936 0.462019838220624 no 1525 0.453486006400478 2105 715507
SGTC_3148 9097893 49.47 µM 0.116406629907931 0.462201056535956 no 1526 0.453665140605323 2080 17174100
SGTC_2174 5790901 200 µM 0.115237761584902 0.462669631362289 no 1527 0.454128334309687 2113 786020
SGTC_3075 9116269 49.47 µM 0.115181848317863 0.462692047123351 no 1528 0.454150492927887 2114 17015205 YNL244C SUI1
SGTC_2330 7979373 200 µM 0.115123259623087 0.462715535596837 no 1529 0.454173711980324 2055 1863007
SGTC_420 mitomycin C 81.9 mM 0.114194730141289 0.463087804580495 no 1530 0.45454171466047 2086 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1146 3579-1023 7 µM 0.113427124551789 0.463395579870975 no 1531 0.454845968096384 2193 X1146
SGTC_3017 9080681 49.47 µM 0.113181979038179 0.463493876812487 no 1532 0.454943141249513 2090 16451914
SGTC_44 0929-0055 61.211 µM 0.11315778011825 0.463503580067646 no 1533 0.454952733598086 2120 1379590
SGTC_1160 4092-0570 10.5 µM 0.112417052245177 0.463800606757174 no 1534 0.455246367646471 2057 4994975
SGTC_205 1486-1330 71.903 µM 0.112145261895077 0.463909597853193 no 1535 0.455354114974634 2132 4118834
SGTC_3009 9080819 71.4286 µM 0.111753129600818 0.464066852241374 no 1536 0.455509575900193 2107 17027216
SGTC_1270 0831-1170 17.3 µM 0.110389159891789 0.464613880141887 no 1537 0.45605037487084 2196 6764716
SGTC_3202 9113761 49.47 µM 0.110024430591717 0.464760168303953 no 1538 0.456194999862414 2190 4798415
SGTC_423 5-fluorouracil 457 µM 0.109567212181171 0.464943559367112 no 1539 0.456376307473253 2021 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2309 7664088 163.95 µM 0.10898263091467 0.465178046725014 no 1540 0.456608133395682 2241 704922
SGTC_899 1083-0020 478 µM 0.108489468943592 0.465375873363133 no 1541 0.456803716887099 2191 767123
SGTC_392 N-ethylmaleimide 8.33 µM 0.10789694575266 0.465613569002197 no 1542 0.457038719957674 2121 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1662 st014054 52 µM 0.107682117190072 0.465699752313619 no 1543 0.457123927716872 2216 2838777
SGTC_3242 9133940 49.47 µM 0.107244755221666 0.465875214874783 no 1544 0.457297405305537 2187 17248444
SGTC_729 4092-0585 94.1 µM 0.106992126471999 0.465976568475553 no 1545 0.457397613032634 2123 2169061
SGTC_869 0564-0080 44.1 µM 0.104784216528485 0.466862465941433 no 1546 0.458273517240876 2050 6843321
SGTC_605 1315-0399 119 µM 0.104621776052809 0.466927649777673 no 1547 0.458337967370339 2171 24020461
SGTC_8 0354-0001 70 µM 0.104043389593205 0.467159750896647 no 1548 0.458567457740737 2160 4993152
SGTC_1559 coumarin 343 70.1 µM 0.103508598409947 0.467374367573504 no 1549 0.458779662803762 2189 108770 A hepatotoxic, DNA x-linker.
SGTC_3236 9132701 49.47 µM 0.1025284187942 0.467767747349646 no 1550 0.459168628383942 2124 24282524
SGTC_1629 st005085 44.9 µM 0.102508089310996 0.467775906604677 no 1551 0.459176696166572 2137 24207091
SGTC_1727 st034309 9.9045 µM 0.102181692466004 0.467906908101723 no 1552 0.459306229491194 2231 870305
SGTC_479 n-linoleoylglycine 10 µM 0.101722789918094 0.468091097499895 no 1553 0.459488356118935 2102 6433346 An anti-infammatory.
SGTC_2580 diallyl disulphide 81.36 µM 0.101367990462826 0.468233507796251 no 1554 0.459629172734295 2141 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2451 5856223 45.7 µM 0.100914797479493 0.468415417444154 no 1555 0.459809048192774 2144 2179896
SGTC_2192 5915882 198.485 µM 0.100818077349527 0.468454241329353 no 1556 0.459847438153936 2214 2876149
SGTC_2869 9037858 32.47 µM 0.0999991522543788 0.468782973448439 no 1557 0.460172499237769 2255 27187042
SGTC_1161 k007-0610 110 µM 0.099888847952061 0.468827253326147 no 1558 0.460216285056681 2240 5843850
SGTC_2792 7535235 81.82 µM 0.0969877962017854 0.469991970402244 no 1559 0.461368042988596 2114 1281891
SGTC_1465 k213-0056 144 µM 0.095690847395993 0.470512754326651 no 1560 0.461883055130648 2100 24048857 YMR208W ERG12
SGTC_836 0330-0104 1.35 µM 0.0946393682581759 0.470935008079559 no 1561 0.462300639404231 2245 46494820
SGTC_2832 7992762 51.95 µM 0.0942569649892282 0.471088581989379 no 1562 0.462452517312395 2031 2985177
SGTC_843 0310-0051 143 µM 0.0940692778404234 0.471163959094285 no 1563 0.462527062433405 2128 2065037
SGTC_1588 farnesol 29.9 µM 0.0935536303659001 0.471371053776026 no 1564 0.462731872798858 2205 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2945 9067681 61.76 µM 0.0935464224165987 0.471373948692414 no 1565 0.462734735799211 2237 16456930
SGTC_2404 5161160 200 µM 0.0921798180592769 0.471922842826087 no 1566 0.463277586310686 2177 2831543
SGTC_2087 5276107 200 µM 0.0917710185524507 0.4720870468083 no 1567 0.463439985356731 2229 144405
SGTC_609 0986-0026 86.3 µM 0.0914699148038069 0.472207995280093 no 1568 0.463559605254063 2206 2848610
SGTC_2231 micatex 6.853 µM 0.0905895311235748 0.472561645726153 no 1569 0.46390937534033 2177 20737 An antifungal of unknown mechanism.
SGTC_490 phenamil 164 µM 0.0891071930635044 0.473157150196596 no 1570 0.464498360449888 2244 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1 0258-0098 57.368 µM 0.0889012513652171 0.47323988859905 no 1571 0.464580194523112 2145 6790032 YDR047W HEM12
SGTC_2769 toremifene 3.73 µM 0.087549074701052 0.473783162785984 no 1572 0.465117539588677 2216 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1449 4112-4002 201 µM 0.087345915723593 0.473864791734401 no 1573 0.465198278993641 2086 2059539
SGTC_551 k048-0028 34.9 µM 0.0870616885407002 0.473978995597363 no 1574 0.465311238914151 2234 6836383
SGTC_1391 3442-0225 151 µM 0.0862022292145126 0.474324343501793 no 1575 0.465652829324632 2194 5227075
SGTC_57 miconazole 162.5 nM 0.0861104050088261 0.474361241445034 no 1576 0.465689326174516 2245 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1458 k015-0034 6.33 µM 0.0854042089373243 0.474645021251225 no 1577 0.465970023571193 2073 3598957
SGTC_1909 st060837 51.5 µM 0.0839802014175424 0.47521728739572 no 1578 0.466536086566311 2175 678937
SGTC_451 chloral hydrate 100 µM 0.0830682076126249 0.475583817434752 no 1579 0.466898652550547 2153 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2237 6667747 47.222 µM 0.0816151218029007 0.476167854751647 no 1580 0.467476387976494 2108 729940 YDL015C TSC13
SGTC_1677 st019204 53.9 µM 0.0806967558239755 0.476536999151081 no 1581 0.467841558440673 2090 3945625
SGTC_1612 st002233 45.4 µM 0.0796626244228391 0.476952700456822 no 1582 0.468252793165687 2267 1035021
SGTC_1173 0443-0020 122 µM 0.0786795084549637 0.477347917784305 no 1583 0.468643772413726 2197 5331295
SGTC_3313 9133968 57.047 µM 0.0779572767715976 0.477638272597929 no 1584 0.46893101885807 2269 1494643
SGTC_3026 9090633 49.47 µM 0.077393722905955 0.477864843297985 no 1585 0.469155167101081 2233 25236842
SGTC_1334 1486-0610 236 µM 0.0770892616322587 0.477987251621804 no 1586 0.469276267777719 2206 3742339
SGTC_2920 7982904 15.77 µM 0.0754831210135614 0.478633032811747 no 1587 0.46991516335006 2215 6456808
SGTC_2296 7971656 126.45 µM 0.0753211393940397 0.478698163927179 no 1588 0.469979601225884 2202 666570
SGTC_691 1548-0686 185 µM 0.0749272648481809 0.478856539133379 no 1589 0.470136291657323 2206 46495133
SGTC_618 k072-0232 33.2 µM 0.0748417083613976 0.478890941459082 no 1590 0.470170328190238 2225 5872756 YGL099W LSG1
SGTC_1351 1496-0003 46.5 µM 0.0738540502492218 0.479288090827485 no 1591 0.470563259267415 2259 3891978
SGTC_2053 5265679 138 µM 0.0736866950372721 0.47935538844688 no 1592 0.47062984291415 2261 764595
SGTC_2027 5150920 200 µM 0.0733076154553299 0.479507827781458 no 1593 0.470780665875369 2247 786715
SGTC_2844 9010103 25.97 µM 0.0731185598102895 0.479583853880629 no 1594 0.470855886298415 2170 2480525
SGTC_2206 7254556 146.969 µM 0.0715115026917779 0.480230139270288 no 1595 0.471495335086447 2270 4398905
SGTC_2247 cerulenin 830 nM 0.070882930640569 0.480482936636502 no 1596 0.471745464287855 2258 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2584 androsterone 48.74 µM 0.0708817779576987 0.480483400226547 no 1597 0.471745922988013 2289 2754130 A steroid.
SGTC_772 k072-0172 35.3 µM 0.0702780958832244 0.480726194815367 no 1598 0.471986158172896 2098 5861980
SGTC_989 1501-0895 10.3 µM 0.0692245306049297 0.481149944777726 no 1599 0.472405448670965 2300 2830112
SGTC_921 1561-0023 372 µM 0.0687813002288324 0.481328220955195 no 1600 0.472581851543684 2309 24050882
SGTC_1819 st053448 58.6 µM 0.0682975629041225 0.481522794103061 no 1601 0.472774382060889 2230 2857616
SGTC_2705 st078069 42.8 µM 0.0672508061461065 0.481943844962762 no 1602 0.473191019591386 2223 1530061
SGTC_556 4058-0063 51.5 µM 0.0670042816274021 0.482043010738683 no 1603 0.473289147308553 2214 6615692
SGTC_1021 4476-0760 85.3 µM 0.0663925902756567 0.482289071566916 no 1604 0.473532634645946 2243 746768
SGTC_2722 naftopidil 47.16 µM 0.0663732618839267 0.482296846775158 no 1605 0.473540328587511 2281 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1174 0739-0097 51.1 µM 0.066353187840094 0.482304921943078 no 1606 0.473548319356962 2218 728447
SGTC_1142 3253-1408 9.78 µM 0.0652712191087339 0.482740175205083 no 1607 0.473979028644318 2302 256655
SGTC_2244 6635614 200 µM 0.0638044742903148 0.483330248541046 no 1608 0.474562957776117 2150 836499
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0634462916127836 0.483474351491603 no 1609 0.474705563050633 2189 688803
SGTC_1197 1601-0112 267 µM 0.0633318750742391 0.483520383656461 no 1610 0.474751117031457 2281 7350313
SGTC_624 k048-0052 28 µM 0.0630396862145463 0.483637938336992 no 1611 0.474867451060611 2210 6835531
SGTC_320 4092-0846 5.34 µM 0.0630041171021128 0.483652248752821 no 1612 0.474881612931716 2281 1359356
SGTC_3007 9078383 71.4286 µM 0.0621154854962706 0.484009776066408 no 1613 0.475235432584411 2238 6496995
SGTC_214 4373-3496 70 µM 0.0612106588983038 0.484373832395623 no 1614 0.475595720539317 2239 3779166
SGTC_561 1550-0330 72.9 µM 0.0607145453452667 0.484573448874605 no 1615 0.475793273770943 2253 6812934
SGTC_879 0831-1030 162 µM 0.0597799463658034 0.484949505014772 no 1616 0.476165448744805 2296 1549252
SGTC_1470 k295-0292 231 µM 0.0596996339337459 0.484981821090491 no 1617 0.476197431647664 2293 5045612
SGTC_161 4065-0411 162.148 µM 0.0596929963225904 0.48498449193352 no 1618 0.476200074957281 2242 1906281 YLR208W SEC13
SGTC_1158 4092-0494 91.8 µM 0.059157169573204 0.485200100197555 no 1619 0.476413461796419 2249 1148199
SGTC_1649 st011737 51.3 µM 0.0589848251680495 0.48526944980069 no 1620 0.47648209741385 2215 1761035
SGTC_1502 4534-4282 27.7 µM 0.0581859686194997 0.485590907185314 no 1621 0.47680024860283 2216 3278949
SGTC_1600 coumarin 106 71.1 µM 0.0575698707257193 0.485838829463456 no 1622 0.477045624766162 2269 100336 A hepatotoxic, DNA x-linker.
SGTC_1326 1431-2094 10.8 µM 0.0574036232791602 0.485905729588155 no 1623 0.477111838402121 2299 616278
SGTC_1166 k206-0078 225 µM 0.0568457115363123 0.48613024338463 no 1624 0.477334050122543 2288 5404595
SGTC_865 0488-0499 301 µM 0.0566658578389616 0.48620262071246 no 1625 0.477405685896381 2318 9634651
SGTC_3005 9076496 71.4286 µM 0.0556679144784165 0.486604224616798 no 1626 0.477803180193699 2325 21368410
SGTC_1941 st076221 61.8 µM 0.055490215388505 0.486675737775592 no 1627 0.477873962464923 2315 2828568
SGTC_258 haloperidol 50.781 µM 0.0527314628923931 0.487786022686747 no 1628 0.478972935064029 2270 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_727 3032-0951 202 µM 0.0527088769397696 0.487795113010245 no 1629 0.478981933042217 2264 3652836
SGTC_2143 5623677 140.463 µM 0.0522242419057275 0.487990168921395 no 1630 0.479175008519728 2308 5375313
SGTC_262 fenpropimorph 62.5 µM 0.0522208049292806 0.487991552246008 no 1631 0.479176377806522 2298 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1296 1068-0102 11.9 µM 0.0519883027602301 0.488085130752587 no 1632 0.479269006927768 2295 767053
SGTC_91 0417-1751 58.384 µM 0.0517217232713807 0.488192425657247 no 1633 0.47937521386844 2317 6795624
SGTC_2752 diclazuril 33.15 µM 0.0514456104111589 0.488303558525333 no 1634 0.479485220507852 2297 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1723 st034307 2.5525 µM 0.0509065107973459 0.488520543734931 no 1635 0.479700008686358 2296 867466
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0508289153183912 0.488551775853173 no 1636 0.479730924779717 2323 688664
SGTC_796 1234-0020 70.7 µM 0.0495136649085958 0.4890811736167 no 1637 0.480254973767405 2335 46495034
SGTC_2062 5245942 200 µM 0.0487714273250287 0.489379938141626 no 1638 0.480550726379339 2324 1376160
SGTC_474 dl-dihydrosphingosine 5 µM 0.0485771365136987 0.48945814482196 no 1639 0.48062814543415 2298 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2624 nerol 100 µM 0.0485582385071598 0.489465751741494 no 1640 0.48063567576139 2301 637566 A natural product oil.
SGTC_2153 5569715 200 µM 0.0481077480264553 0.489647086537327 no 1641 0.480815185662457 2324 2054701
SGTC_2504 purpurogallin 52.29 µM 0.0480054728846546 0.489688255391351 no 1642 0.480855940453229 2188 5281571 An antioxidant.
SGTC_3051 9093778 49.47 µM 0.0464099160101956 0.49033052949234 no 1643 0.481491766598593 2329 17217378
SGTC_2218 6965428 192.983 µM 0.0461061138849606 0.490452824632718 no 1644 0.481612836508506 2300 675684
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0451568185043492 0.490834967953645 no 1645 0.481991156478396 2319 66535 A nucleotide analog.
SGTC_978 1416-0512 87.4 µM 0.0447912095283962 0.490982147829819 no 1646 0.482136865921175 2269 6814003
SGTC_1219 1469-0211 33.1 µM 0.0432026794887068 0.491621641899901 no 1647 0.482769984580807 2331 6822282
SGTC_295 k015-0027 31 µM 0.0422900930777024 0.491989031387542 no 1648 0.483133721400516 2279 3887424
SGTC_2207 7258803 200 µM 0.0422390661547016 0.492009574034893 no 1649 0.483154060024035 2313 3666799
SGTC_3206 9114350 49.47 µM 0.0406231404243411 0.492660131331691 no 1650 0.483798167995182 2343 17087243
SGTC_391 gliotoxin 8.33 µM 0.0397649318290443 0.493005646510837 no 1651 0.484140267226109 2296 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_956 1185-0240 191 µM 0.0395591712287907 0.493088486613735 no 1652 0.484222289290102 2314 1416193
SGTC_1188 1403-0014 4.57 µM 0.0388940691189728 0.493356261605359 no 1653 0.484487422575152 2315 9614867
SGTC_1961 st076550 68.7 µM 0.0383339634938807 0.493581766568576 no 1654 0.484710705863101 2310 1579337
SGTC_95 0471-0001 561.058 µM 0.0377499408276688 0.493816902990733 no 1655 0.484943528663664 2305 4015405
SGTC_3109 9122853 49.47 µM 0.0376085784901846 0.493873817947289 no 1656 0.484999884058067 2265 1234709
SGTC_1017 4239-0030 168 µM 0.0371578790077601 0.494055278291133 no 1657 0.485179561541805 2278 1149593
SGTC_499 genistein 192 µM 0.0359363651476365 0.494547089515046 no 1658 0.485666549694699 2346 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1921 5740136 50 µM 0.0348851623751864 0.494970336011271 no 1659 0.486085656060845 2336 1774243
SGTC_3267 9137951 49.47 µM 0.0344007400652084 0.495165381234115 no 1660 0.486278796667886 2317 16643986
SGTC_1327 1436-0082 2.18 µM 0.0343265361178429 0.495195258420122 no 1661 0.486308382286467 2222 15992205
SGTC_2269 7935389 174.42 µM 0.0336427693012145 0.495470568853156 no 1662 0.486581008293176 2347 97605
SGTC_2816 7982706 58.44 µM 0.0335500220132683 0.495507912595185 no 1663 0.486617988231869 2311 2981853
SGTC_1047 2043-3044 82 µM 0.0329580048034189 0.495746283152392 no 1664 0.486854038372476 2334 669592
SGTC_2853 9015042 58.44 µM 0.0329484444503281 0.495750132557728 no 1665 0.486857850331246 2337 6457456
SGTC_2132 5317594 122.667 µM 0.0322201340693368 0.496043382473166 no 1666 0.487148249924298 2323 794577
SGTC_2534 helenine 20.12 µM 0.0320235276799325 0.496122545259111 no 1667 0.487226644071057 2337 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2386 9075165 157.42 µM 0.0315195232604571 0.496325481337381 no 1668 0.487427611284617 2335 16452277
SGTC_505 gw-5074 63.9 µM 0.0314599903004337 0.496349452193845 no 1669 0.48745134972695 2327 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_718 1130-0073 349 µM 0.0299912649824818 0.496940836182947 no 1670 0.488037009786359 2317 6740020
SGTC_698 k064-0052 127 µM 0.0296006058692135 0.497098136723086 no 1671 0.488192791056393 2362 5088751
SGTC_419 nsc-638432 893 µM 0.029267529684883 0.497232251611209 no 1672 0.488325611680314 2303 368090
SGTC_1672 st016598 6.51 µM 0.0290021286067242 0.497339116984386 no 1673 0.488431446463505 2242 4665860 YNL267W PIK1
SGTC_2536 dehydroabietamide 32.04 µM 0.0289846033262159 0.497346173652959 no 1674 0.48843843510088 2356 3983547
SGTC_2232 chlorophetanol 41.5365 µM 0.0289315629904643 0.49736753069536 no 1675 0.488459586263145 2355 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1253 0550-0034 176 µM 0.0279372580945046 0.497767895474954 no 1676 0.488856096184773 2309 5969915
SGTC_1378 2093-0007 380 nM 0.0273825852457889 0.497991239914567 no 1677 0.489077294000849 2320 3618014
SGTC_1311 1190-0148 100 µM 0.0223939066114573 0.5 no 1678 0.491066870477035 2356 1961333
SGTC_1002 4049-0206 172 µM 0.0221459874749921 0.499900171528085 no 1679 0.49116575137938 2365 4662749
SGTC_2063 5246145 200 µM 0.0218611941050994 0.499785495084282 no 1680 0.491279339994677 2352 711240
SGTC_2076 5212012 200 µM 0.0216172435456933 0.499687264641923 no 1681 0.491376639192703 2371 604802
SGTC_2914 7968218 45.32 µM 0.0215657915985542 0.499666546726793 no 1682 0.491397160765752 2352 2977111
SGTC_1223 0764-0573 147 µM 0.0213676892920761 0.499586777805626 no 1683 0.491476173943961 2365 1609797
SGTC_1850 st056238 17 µM 0.0207235958791872 0.499327423880402 no 1684 0.491733073135375 2365 5393177
SGTC_1222 0366-0074 1.18 µM 0.0204889695778526 0.499232948127013 no 1685 0.491826655616303 2368 286520
SGTC_2450 5739737 12.93 µM 0.0190438304153631 0.498651042600313 no 1686 0.492403070062528 2335 2262825
SGTC_1923 st058458 19.1 µM 0.0188887937307962 0.498588615056165 no 1687 0.492464909627457 2377 3534982
SGTC_2263 7948595 193.29 µM 0.0169764181624579 0.497818575395971 no 1688 0.493227714320854 2378 2971371
SGTC_2651 TUB2.036 5 µM 0.0165193182887501 0.497634520055677 no 1689 0.493410045212367 2358 15992207 YFL037W TUB2
SGTC_530 4358-1714 28 µM 0.0154123980249366 0.497188810903492 no 1690 0.493851586204206 2319 1564641
SGTC_2466 5983409 37.09 µM 0.0146285492384274 0.496873190820823 no 1691 0.494164261344549 2300 2879657
SGTC_2690 usnic acid 100 µM 0.0130408501503278 0.496233903163352 no 1692 0.494797600959674 2373 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_797 k781-0471 270 µM 0.0130283323826848 0.496228862915594 no 1693 0.494802594402231 2321 23738129
SGTC_429 1112-0049 25.5 µM 0.0115958502033477 0.495652081734475 no 1694 0.495374028747816 2371 2836170
SGTC_1935 st074532 41.6 µM 0.00858680147873581 0.49444053562209 no 1695 0.496574403933441 2360 2829742
SGTC_1029 k015-0030 64.7 µM 0.008225770637848 0.494295175461019 no 1696 0.496718429310705 2348 2208316
SGTC_3301 9125354 19.7965 µM 0.00736462693015546 0.493948460286577 no 1697 0.497061965496922 2384 41905162
SGTC_1434 4073-0095 163 µM 0.00700947261636979 0.493805468756773 no 1698 0.497203647908757 2392 24133745
SGTC_2021 4019055 173 µM 0.00598597599750268 0.493393395081836 no 1699 0.497611955346503 2387 44827708 YER133W GLC7
SGTC_2487 5918373 44.05 µM 0.00585367212149705 0.493340128245117 no 1700 0.497664736031624 2395 2876279
SGTC_1018 4259-0013 28.1 µM 0.00571632407431325 0.493284830701303 no 1701 0.497719529057869 2357 6801262
SGTC_2967 9089538 49.85 µM 0.00558140275973353 0.493230510307227 no 1702 0.497773354015966 2395 728216
SGTC_513 4245-1575 41.7 µM 0.00479104790382727 0.492912309711919 no 1703 0.498088655735948 2389 719745
SGTC_3152 9099253 49.47 µM 0.00390325505345339 0.492554885508301 no 1704 0.498442830482005 2386 25236131
SGTC_69 0096-0274 206.684 µM 0.00270852539583501 0.492073898446935 no 1705 0.498919456023225 2395 6741392
SGTC_2775 cyproheptadine 69.59 µM 0.00191106172382817 0.491752853351059 no 1706 0.499237597141977 2399 2913 A selective serotonin reuptake inhibitor.
SGTC_1572 epiandrosterone 68.9 µM 0.00141101958549991 0.491551547737834 no 1707 0.499437084815661 2396 441302 A steroid.
SGTC_3059 1327-0034 3 µM 0.00139136362841053 0.491543634739346 no 1708 0.499444926400308 2401 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_249 wiskostatin 11.211 µM 0.000871043423506358 0.491334168011158 no 1709 0.49965250399424 2400 2775510 A n-wasp and actin depolymerizer.
SGTC_3163 9099914 49.47 µM 0.000765641226194416 0.491291736249476 no 1710 0.499694553373095 2404 16268368
SGTC_2986 9022445 71.43 µM 2.7997818846958e-05 0.490994785934097 no 1711 0.499988830486304 2405 6459286
SGTC_1618 st003135 44.5 µM 0 0.490983515055376 no 1712 0.5 2402 1270615
SGTC_1747 st037496 66.6 µM 0 0.490983515055376 no 1713 0.5 2406 723305
SGTC_2985 9022375 71.43 µM -0.000379145753481372 0.490830885813846 no 1714 0.499848742732126 2408 4939335
SGTC_813 k007-0158 173 µM -0.000408906799389816 0.490818905238074 no 1715 0.499836869793526 2409 6523916
SGTC_639 0833-0042 114 µM -0.000891208993870743 0.490624751329335 no 1716 0.499644459098736 2410 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2518 prenyletin 46.28 µM -0.0016972996391335 0.490300259239804 no 1717 0.499322875736552 2409 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2122 5258151 111.688 µM -0.00192483772201133 0.490208664852287 no 1718 0.499232101323956 2409 2173356
SGTC_2460 5552655 174.22 µM -0.00291412287664375 0.489810438820884 no 1719 0.498837434819661 2420 5401989
SGTC_98 0074-0023 107.663 µM -0.00352324245866887 0.489565249353003 no 1720 0.498594432527073 2421 3563821
SGTC_38 0929-0051 58.268 µM -0.00422129967372135 0.489284264592048 no 1721 0.498315950083361 2417 1379719
SGTC_3073 9114972 49.47 µM -0.00433769012805289 0.489237415157917 no 1722 0.498269517435307 2412 41905075
SGTC_2363 9053361 176 µM -0.00437311853750261 0.489223154559686 no 1723 0.498255383678907 2412 6469797 YMR079W SEC14
SGTC_2569 tetrandrine 100 µM -0.00500274643656318 0.48896971985507 no 1724 0.498004201253297 2416 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2280 7785178 200 µM -0.00649534750296207 0.488368943443478 no 1725 0.497408749475792 2421 2954328
SGTC_2925 9010536 32.5 µM -0.00757218821602609 0.487935528132061 no 1726 0.496979162833642 2431 2994177
SGTC_48 0382-0018 55 µM -0.00804077482737456 0.487746932129658 no 1727 0.496792229520107 2414 762596
SGTC_83 0170-0301 39.027 µM -0.0105615126945164 0.486732437589062 no 1728 0.495786644371485 2425 3089716
SGTC_108 0509-0257 621.132 µM -0.011107342809787 0.48651277423416 no 1729 0.495568902443464 2430 536624
SGTC_919 tnp00227 403.569 nM -0.0115749250166274 0.486324604145093 no 1730 0.495382376129307 2442 1269246 A methoxyflavone. YNL221C POP1
SGTC_984 1492-0255 2.91 µM -0.0116763328015632 0.486283794797656 no 1731 0.49534192301017 2442 1585198
SGTC_643 k048-0106 28.4 µM -0.0129869510951707 0.485756378177886 no 1732 0.494819101750866 2451 6763920
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0131420864226447 0.485693950533937 no 1733 0.494757216991137 2442 521171
SGTC_152 4469-0003 551.229 µM -0.0142671950147621 0.48524120880668 no 1734 0.494308405776575 2434 697280
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.0161924932134515 0.484466516634906 no 1735 0.493540412113859 2431 88881 An O-methylated flavonoid and antioxidant.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0171226509652061 0.484092265084777 no 1736 0.493169384351596 2425 23665772 A membrane-active detergent.
SGTC_125 0133-0007 11.75 µM -0.0181071727193556 0.483696155301006 no 1737 0.492776677943952 2440 26541
SGTC_960 1222-0186 7.7 µM -0.0181696812518537 0.483671006328507 no 1738 0.492751744749336 2457 3126296
SGTC_3352 9151559 45.5865 µM -0.0182610970682421 0.483634227244966 no 1739 0.492715281164912 2451 17159339
SGTC_602 3130-1533 38.1 µM -0.019301749468709 0.483215554209719 no 1740 0.492300194157629 2455 720941
SGTC_1999 st074831 12.5 µM -0.0193123020643349 0.483211308806152 no 1741 0.492295985065632 2458 17112523
SGTC_2259 7964009 200 µM -0.0195238814805865 0.483126188917652 no 1742 0.492211593003016 2537 313134
SGTC_2453 5731132 22.18 µM -0.0196528017087834 0.483074323779189 no 1743 0.492160171139536 2449 1362040
SGTC_1744 st037937 38.9 µM -0.0201067022052165 0.48289172002639 no 1744 0.491979126820271 2471 1016152
SGTC_789 1309-1135 70.6 µM -0.0201822068264621 0.482861344933713 no 1745 0.491949010945614 2437 3092424
SGTC_45 0kpi-0036 14.9 µM -0.0207663447738506 0.482626352834489 no 1746 0.49171602246316 2445 2795021
SGTC_1660 st012960 28.1 µM -0.0239211797058341 0.481357304761729 no 1747 0.490457740076783 2476 24207266
SGTC_1885 st057546 99.9 µM -0.0240951126341471 0.481287344751033 no 1748 0.490388370872589 2494 702008
SGTC_347 4534-1311 26.2 µM -0.0249366400509511 0.480948870344839 no 1749 0.490052750889501 2448 2862016
SGTC_2431 5490079 200 µM -0.0250308359825321 0.480910984239285 no 1750 0.490015183876019 2471 5722345
SGTC_3312 9133330 71.43 µM -0.0250917892079036 0.480886468619146 no 1751 0.489990874692421 2460 17617324
SGTC_2718 lomofungin 53.02 µM -0.025111151373786 0.480878681097172 no 1752 0.489983152738933 2450 5351222 A RNA synthesis inhibitor.
SGTC_858 0438-0351 2.77 µM -0.0256150161252262 0.48067602773705 no 1753 0.489782204432118 2459 2799119
SGTC_3200 9114385 49.47 µM -0.0278278447668876 0.479786092464071 no 1754 0.488899728823074 2479 17018030 YLR208W SEC13
SGTC_395 anisomycin 6.25 µM -0.0288581900585089 0.47937175168507 no 1755 0.488488845610865 2487 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1392 3455-1037 33.9 µM -0.02953999404048 0.479097584765553 no 1756 0.488216961108075 2489 981132
SGTC_2412 st077135 33.4 µM -0.0308195132837742 0.478583091468143 no 1757 0.48770673923056 2646 13258915
SGTC_2202 7226349 200 µM -0.0309183604704546 0.478543346595767 no 1758 0.487667323692346 2462 844334
SGTC_209 4077-0173 175.592 µM -0.0310325650599979 0.478497427023093 no 1759 0.48762178450518 2519 15993494
SGTC_1859 st055998 20 µM -0.0325141111945199 0.477901750561051 no 1760 0.487031031436937 2466 676301
SGTC_1255 0566-0045 221 µM -0.034114950422781 0.477258166159173 no 1761 0.486392743355628 2513 2788469
SGTC_2948 9070189 9.45 µM -0.0348606987915063 0.47695837355316 no 1762 0.486095409686106 2480 6473636 YDL196W YDL196W
SGTC_189 3970-0742 2.116 µM -0.035358061409368 0.476758439843895 no 1763 0.485897112965931 2480 2891807
SGTC_2156 5649887 115 µM -0.0357706027926478 0.476592607673648 no 1764 0.485732636816291 2519 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_673 1082-0474 110 µM -0.037059711462321 0.476074441822796 no 1765 0.485218697770429 2472 3098046
SGTC_2819 7996655 46.38 µM -0.0370947603494271 0.4760603542492 no 1766 0.485204724895189 2480 6456960
SGTC_2130 NSC 7 2.4545 µM -0.0375151140217904 0.475891399343905 no 1767 0.485037144691567 2493 21448
SGTC_1377 2944-0135 198 µM -0.0381031969005781 0.475655035459959 no 1768 0.484802701202379 2506 1894137
SGTC_1714 st033236 13.627 µM -0.0383797534355301 0.475543884055285 no 1769 0.484692451752469 2502 2916566
SGTC_2064 5220758 200 µM -0.0388509023370024 0.475354528020772 no 1770 0.484504630623391 2531 788518
SGTC_1524 corynanthine 62.1 µM -0.0393385332061134 0.475158553700647 no 1771 0.484310242662158 2631 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_689 0833-0039 98 µM -0.0397320843222758 0.475000393540252 no 1772 0.484153361137455 2506 5374726
SGTC_448 monastrol 171 µM -0.0402516836386838 0.474791583219259 no 1773 0.483946236702158 2466 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_496 calpeptin 138 µM -0.0416120281749885 0.474244937266361 no 1774 0.483403992225563 2547 73364 A calpain inhibitor.
SGTC_2133 5320837 200 µM -0.0425535440091089 0.473866623341537 no 1775 0.48302871421402 2517 2841355
SGTC_2951 9072950 58.06 µM -0.0427696214940556 0.473779803768672 no 1776 0.482942590178601 2477 16488155
SGTC_1454 4239-0054 42.6 µM -0.0429249600108015 0.473717389781096 no 1777 0.48288067593653 2611 1340767
SGTC_1625 st003711 30.1 µM -0.0442366742427158 0.473190377563775 no 1778 0.482357874418098 2511 24207034 YER133W GLC7
SGTC_1152 3909-8331 15.9 µM -0.0443114092090921 0.473160352427568 no 1779 0.482328088687361 2493 16001939
SGTC_58 0957-0393 9 µM -0.0444490261726039 0.47310506454224 no 1780 0.482273241502374 2480 6997992
SGTC_779 1360-0071 233 µM -0.0445542962697326 0.473062772423696 no 1781 0.482231286374285 2521 7566
SGTC_2254 7938975 95.19 µM -0.0448785802333343 0.472932493692249 no 1782 0.48210204506839 2525 2969277
SGTC_1312 1218-2183 165 µM -0.0449307130713284 0.472911549972312 no 1783 0.482081268033373 2469 6744073
SGTC_110 0850-0284 111.64 µM -0.0449998477736213 0.472883776080146 no 1784 0.482053715145942 2474 3906265
SGTC_1512 0259-0544 12.2 µM -0.0452912409952016 0.472766714411086 no 1785 0.481937584474495 2493 18476
SGTC_2673 kobusone 100 µM -0.0474463737685501 0.471901004618635 no 1786 0.481078734845641 2504 6710676 An epoxy ketone and protein crosslinker.
SGTC_1246 0422-0085 105 µM -0.0475867990862963 0.471844600789514 no 1787 0.481022776457022 2500 264295
SGTC_1684 st024538 14.6195 µM -0.0485271713430457 0.471466901484876 no 1788 0.480648055172705 2486 6732859
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0493096567988249 0.471152636755974 no 1789 0.480336261934176 2513 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1899 st063254 59.6 µM -0.0494544620568621 0.471094481491674 no 1790 0.480278563388762 2480 3093813
SGTC_750 4073-0104 132 µM -0.0503891779151272 0.470719104981917 no 1791 0.479906130102452 2503 22330957
SGTC_259 usnic acid 108.925 µM -0.0504827767742671 0.470681517646195 no 1792 0.479868837023175 2572 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2876 9059903 25.97 µM -0.0515358509549672 0.470258643255276 no 1793 0.479449267432249 2494 6916095
SGTC_767 0929-0023 86 µM -0.052483780246065 0.469878019707189 no 1794 0.479071609505193 2509 1204563
SGTC_1787 fluconazole 80 µM -0.0529654352701962 0.469684630526365 no 1795 0.478879723848752 2522 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1125 tnp00248 1.32998 µM -0.0533709589657798 0.469521814358058 no 1796 0.47871817180571 2535 24207736
SGTC_1266 0828-0227 32.9 µM -0.0546280717967637 0.469017121008597 no 1797 0.478217387042716 2557 3913820
SGTC_2226 7298446 200 µM -0.0557587208636016 0.468563241590725 no 1798 0.477767009866787 2515 3283010
SGTC_2162 5663267 200 µM -0.0559417841051425 0.46848975786156 no 1799 0.477694092013114 2512 6456493
SGTC_799 1310-0557 151 µM -0.057612989271644 0.467818966482059 no 1800 0.477028451458733 2622 5354492
SGTC_3004 9076122 71.4286 µM -0.0589069974101084 0.467299637796627 no 1801 0.476513092302534 2536 44782551
SGTC_667 1498-1044 59 µM -0.0601435356623048 0.466803425687991 no 1802 0.476020658127473 2554 6739982
SGTC_1404 3909-7820 48.3 µM -0.060458208758613 0.466677158299761 no 1803 0.475895349755444 2518 23741373
SGTC_2272 7805186 180 µM -0.0609587821641551 0.466476302487694 no 1804 0.475696017521866 2512 2956062 YPR165W RHO1
SGTC_455 paf C-16 10 µM -0.0620405039122789 0.466042289278087 no 1805 0.475265288325853 2511 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2049 5262831 67.185 µM -0.0626827778843639 0.465784612332788 no 1806 0.475009555839481 2536 763417
SGTC_2114 5491910 81.25 µM -0.0633203168145615 0.4655288492467 no 1807 0.474755718873533 2580 2849228
SGTC_1185 1319-0113 81.3 µM -0.0633427019953298 0.465519869185908 no 1808 0.474746806369896 2585 4672763
SGTC_658 3253-0951 102 µM -0.0637428009857644 0.465359368053251 no 1809 0.474587511882349 2558 1184878
SGTC_833 3852-0053 558 µM -0.0641569204424905 0.465193248495676 no 1810 0.4744226395976 2595 3123681
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0642220848290856 0.46516710905579 no 1811 0.474396696270752 2595 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2484 5809818 12.04 µM -0.0648484341929939 0.46491586874165 no 1812 0.474147338834176 2557 2870548
SGTC_2436 5633522 8.09 µM -0.0654353217170315 0.464680469991337 no 1813 0.473913700833857 2546 5724242
SGTC_2962 9082311 13.18 µM -0.0661170651385459 0.464407040362054 no 1814 0.473642312281656 2548 16459453
SGTC_170 4197-0004 226 µM -0.0687197341331293 0.463363332915693 no 1815 0.472606354884655 2599 218692
SGTC_2814 7977482 42.97 µM -0.0693533238380487 0.463109292278103 no 1816 0.472354190796066 2586 6456762
SGTC_2046 4110841 106 µM -0.0698181390200546 0.462922932104191 no 1817 0.472169204778896 2546 44119630 YMR134W ERG29
SGTC_1571 st070080 73.4 µM -0.0702716408746354 0.462741115669318 no 1818 0.471988726997761 2593 4315245
SGTC_3253 9135987 49.47 µM -0.0711873323033907 0.462374023512926 no 1819 0.471624331597822 2554 4182430
SGTC_600 1495-0418 41.6 µM -0.0718486942922546 0.462108909570452 no 1820 0.471361160241827 2542 5377768
SGTC_2297 7971671 152.32 µM -0.0723803713442817 0.461895793405713 no 1821 0.471149602607919 2578 909016
SGTC_1673 st016611 27.3 µM -0.0761243527895998 0.460395378014781 no 1822 0.469660082813959 2719 5226799
SGTC_1306 1185-0270 9.02 µM -0.0765065495559712 0.460242242499258 no 1823 0.469508051728748 2563 1548076
SGTC_675 1309-0189 238 µM -0.0778070214578213 0.459721224218402 no 1824 0.468990780534331 2579 4246530
SGTC_1132 3456-3614 2.5 µM -0.0780709563592101 0.459615490317965 no 1825 0.468885805063891 2681 3125502
SGTC_2004 4023728 41.89 µM -0.0786769178641795 0.45937274933246 no 1826 0.46864480271606 2564 360084 YDR527W RBA50
SGTC_1725 st036284 20.55 µM -0.0795067006862749 0.459040372771419 no 1827 0.468314801055132 2599 707914
SGTC_64 000l-0018 272.079 µM -0.081036711845215 0.458427589033414 no 1828 0.467706378334697 2565 6811119
SGTC_2522 biochanin a 4.94 µM -0.0821972282912918 0.457962857176291 no 1829 0.467244938746 2595 5280373 A possible chelator.
SGTC_303 1348-1668 34.2 µM -0.0831392298219955 0.457585672413699 no 1830 0.466870416459368 2582 5380509
SGTC_34 0469-0683 81.75 µM -0.0836281826016207 0.457389906943676 no 1831 0.466676029471432 2626 3690923
SGTC_145 3737-0113 38.366 µM -0.0837909136845917 0.457324755443877 no 1832 0.466611336221836 2644 6849351
SGTC_2664 lyso-paf C-16 73.48 µM -0.0840722985255257 0.457212102080183 no 1833 0.466499474612167 2561 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1789 tunicamycin 25 nM -0.0845142198744075 0.457035184331108 no 1834 0.466323798732489 2637 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1581 himbacine 57.9 µM -0.0849003908675322 0.456880592518047 no 1835 0.466170290521777 2537 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1878 temozolomide 1 mM -0.0850146280240729 0.45683486239618 no 1836 0.466124880665273 2538 5394 DNA alkylating agent.
SGTC_59 0330-0160 1.33 µM -0.0851305543747882 0.456788456659648 no 1837 0.466078799796251 2576 4293482
SGTC_563 tetrahydrosecaminediol 614 µM -0.0856264503434186 0.456589954373562 no 1838 0.465881685671126 2611 334274 A psychoactive constituent of the cannabis plant.
SGTC_3019 9081971 49.47 µM -0.0856818785420796 0.456567767682137 no 1839 0.465859653986796 2617 16451803
SGTC_2709 st078560 56 µM -0.0856845343602719 0.456566704619801 no 1840 0.465858598350786 2589 17250903
SGTC_1370 2001-0092 44.6 µM -0.0857110895494803 0.456556075211453 no 1841 0.465848043193442 2601 790957
SGTC_2640 pentamidine 10.38 µM -0.0873339866662605 0.45590652752533 no 1842 0.465203019882066 2604 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2281 7943571 200 µM -0.0874757541320532 0.455849792143213 no 1843 0.465146678470826 2601 1244024
SGTC_1602 st001878 87.6 µM -0.08841294939222 0.455474749022231 no 1844 0.464774234737418 2745 595405 YLR310C CDC25
SGTC_876 0720-0963 56.8 µM -0.0885696705270959 0.455412036836673 no 1845 0.46471195637051 2598 765861
SGTC_1448 4255-0083 152 µM -0.0893347812689816 0.455105892663293 no 1846 0.464407926553965 2717 5399660
SGTC_1479 0549-0158 134 µM -0.0896517657426917 0.454979065295424 no 1847 0.464281973439097 2598 5440202
SGTC_2277 7947813 106.88 µM -0.0904790135501965 0.454648100188652 no 1848 0.463953285151425 2798 1246798
SGTC_2566 crystal violet carbinol 226 nM -0.091227401510566 0.454348712427547 no 1849 0.463655951237045 2727 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1653 st012112 65 µM -0.0916211569057779 0.454191203530791 no 1850 0.463499520685226 2656 720429
SGTC_2829 7992743 58.44 µM -0.0918387471143551 0.454104166812247 no 1851 0.463413079193451 2612 16462845
SGTC_3041 9091929 49.47 µM -0.0931286553327354 0.453588245158283 no 1852 0.462900676346126 2655 25236887
SGTC_1133 3473-0247 50 µM -0.0960152855476131 0.452433971260841 no 1853 0.461754216270251 2661 711311
SGTC_1305 1181-0477 144 µM -0.0970246495946019 0.452030452215772 no 1854 0.461353409625745 2674 6252086
SGTC_1341 1486-1360 280 µM -0.0981979204935197 0.451561469520533 no 1855 0.46088756684545 2570 3976547
SGTC_1692 fluoroquinolonic acid 71 µM -0.0984091536122925 0.451477042066361 no 1856 0.460803703215707 2685 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1273 0849-0096 14.1 µM -0.0984905890613365 0.451444493837618 no 1857 0.460771372234272 2614 5286025
SGTC_3080 9117754 49.47 µM -0.0985324666182428 0.451427756286971 no 1858 0.460754746375263 2605 9550191
SGTC_937 3122-0005 46.7 µM -0.0989249637918086 0.451270887886171 no 1859 0.46059892394102 2598 759535
SGTC_3060 1327-0027 12.5 µM -0.0993219088672861 0.451112249542591 no 1860 0.46044134183119 2632 16000455 YPR107C YTH1
SGTC_1718 roemerine 11.9335 µM -0.100555479020133 0.450619305528125 no 1861 0.459951670046208 2606 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3264 9137442 49.47 µM -0.100894024816044 0.450484033340457 no 1862 0.459817293205353 2647 17015726
SGTC_1937 st074714 47.2 µM -0.101696427663548 0.450163441552893 no 1863 0.459498818878865 2580 17250970
SGTC_2030 5175110 200 µM -0.10172504639492 0.450152007833099 no 1864 0.459487460560442 2686 2831986
SGTC_223 busulfan 5 mM -0.102543582397504 0.449825004903952 no 1865 0.459162610698616 2683 2478 A DNA alkylator.
SGTC_2066 5222451 176 µM -0.103288067471006 0.449527614698926 no 1866 0.458867172872222 2590 2281147
SGTC_1038 k292-0204 154 µM -0.103465157579196 0.44945687888024 no 1867 0.458796900635693 2570 4454212
SGTC_3195 9113082 49.47 µM -0.105234160481875 0.448750367413133 no 1868 0.458095002528409 2570 17018038
SGTC_1654 st012436 41.8 µM -0.107377886758624 0.447894415391244 no 1869 0.457244598438202 2597 4323132
SGTC_464 bw-b 70c 158 µM -0.107595933379238 0.447807366752697 no 1870 0.457158111478916 2728 5353454
SGTC_1190 1486-1332 13 µM -0.109382784282172 0.447094114659946 no 1871 0.456449443981693 2582 4150046
SGTC_2182 6325192 200 µM -0.109495146096377 0.447049269213703 no 1872 0.456404885738411 2588 736248
SGTC_1248 0469-0687 58.6 µM -0.11023807387335 0.446752771595096 no 1873 0.456110283841348 2691 4017482
SGTC_936 3005-4620 401 µM -0.110866316140098 0.446502067432373 no 1874 0.455861178360708 2626 777207
SGTC_938 3126-1755 342 µM -0.112112619083047 0.446004785514087 no 1875 0.455367055963382 2612 1777771
SGTC_66 0109-0187 42.4 µM -0.11283483622298 0.445716655606346 no 1876 0.455080749691902 2569 759417
SGTC_2515 chrysin 20.77 µM -0.114718488987487 0.444965304000104 no 1877 0.454334129294157 2721 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_403 arphamenine a 50 µM -0.11650616833589 0.444252417053816 no 1878 0.453625698882923 2616 5487158 An arginine aminopeptidase inhibitor.
SGTC_1619 st003326 88.7 µM -0.117611898814044 0.44381156633042 no 1879 0.453187588248001 2745 2849032
SGTC_749 1000-0129 128 µM -0.118226344022459 0.443566619274572 no 1880 0.45294415841223 2733 708470
SGTC_308 4092-1169 104 µM -0.119105416783965 0.443216216613099 no 1881 0.452595919660991 2632 2268590 YDL196W YDL196W
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.119783953093864 0.442945779101343 no 1882 0.452327146992352 2864 6710655
SGTC_452 diindolylmethane 8 µM -0.120481775037516 0.442667682828008 no 1883 0.452050757943779 2706 3071 Inhibits expression of several cancer promoting factors.
SGTC_1809 st050081 57.6 µM -0.120570362112595 0.442632381089894 no 1884 0.452015672576133 2759 5036894
SGTC_2531 methyl deoxycholate 70.07 µM -0.121059578171312 0.442437437867853 no 1885 0.451821922791197 2641 16667744 Haematoxylin.
SGTC_683 panaxydol 45 µM -0.121587709693543 0.442227003225113 no 1886 0.45161277375496 2693 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1906 st060206 94.7 µM -0.122454837543554 0.441881530467683 no 1887 0.451269405579696 2639 5133468
SGTC_1264 0783-0040 158 µM -0.122772478613733 0.441754990008574 no 1888 0.451143634120604 2612 2855798
SGTC_3012 9080433 71.4286 µM -0.127774617027764 0.439763052105826 no 1889 0.44916366903005 2628 17688859
SGTC_1361 1608-0041 5.61 µM -0.127987653168594 0.439678250913362 no 1890 0.44907937201134 2642 X1361
SGTC_1081 sertraline 6 µM -0.128696284337345 0.439396193038893 no 1891 0.448798987814678 2716 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2195 6536160 144.242 µM -0.129327723888739 0.439144885812824 no 1892 0.448549167575283 2640 3834386
SGTC_1135 dihydrocapsaicin 536.708 nM -0.129867924573119 0.438929910292666 no 1893 0.448335460907151 2616 107982 A Capsaicinoid.
SGTC_1610 st001799 48.1 µM -0.129999778260357 0.43887744120162 no 1894 0.44828330106241 2631 621897
SGTC_2355 9061122 103.12 µM -0.130434817405127 0.438704331872181 no 1895 0.448111210786041 2755 5302957
SGTC_3247 9135149 49.47 µM -0.130549112313992 0.438658853965733 no 1896 0.448066000283463 2613 8934436 YOR116C RPO31
SGTC_1597 7-benzyloxygramine 47.5 µM -0.131038684717082 0.438464062439968 no 1897 0.447872352628077 2619 260807
SGTC_957 1187-1561 14.1 µM -0.13129097136877 0.438363688207842 no 1898 0.447772566886228 2626 1538454
SGTC_2861 9024595 19.48 µM -0.131321250783961 0.438351641570288 no 1899 0.447760590834883 2611 16482810
SGTC_3119 9125183 49.47 µM -0.132722087706939 0.437794382517193 no 1900 0.447206586968919 2646 22695334
SGTC_783 0848-0141 92.7 µM -0.133282449284751 0.437571502709263 no 1901 0.446985003599952 2626 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2975 9084847 53.72 µM -0.133686594854856 0.437410768990433 no 1902 0.446825202880361 2751 27211724
SGTC_809 3998-0021 90 µM -0.134070198613139 0.437258214559815 no 1903 0.446673532458639 2628 715485
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.135218404269101 0.436801643323691 no 1904 0.446219598113858 2656 688662
SGTC_1319 1306-0155 43.7 µM -0.135827037626443 0.43655966111817 no 1905 0.445979008100938 2642 3122360
SGTC_1191 1487-1166 10.6 µM -0.137145482473436 0.436035551540697 no 1906 0.44545790113951 2766 3955771
SGTC_2271 7849410 118.62 µM -0.13736148564596 0.435949696415264 no 1907 0.44537253621464 2623 972430
SGTC_1900 st060200 72.8 µM -0.137651453826187 0.43583444704634 no 1908 0.445257944140322 2632 688945
SGTC_73 0327-0325 16.231 µM -0.138730633412443 0.435405569429873 no 1909 0.444831505100266 2830 53298
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.140659601952169 0.434639166079939 no 1910 0.444069430344547 2680 641818 YHR062C RPP1
SGTC_3126 9127922 49.47 µM -0.142161681363641 0.434042541020574 no 1911 0.443476149081835 2907 45595682
SGTC_863 0466-0191 129 µM -0.142792983977276 0.433791832750996 no 1912 0.44322683913699 2652 765160 YPR165W RHO1
SGTC_1286 0929-0070 131 µM -0.143051585544702 0.433689142378354 no 1913 0.443124720361455 2771 1420408
SGTC_944 3370-0224 231 µM -0.1434254326379 0.433540696059554 no 1914 0.442977099137148 2695 4580514
SGTC_1508 1080-0625 72.9 µM -0.143677918190592 0.433440444996391 no 1915 0.442877404493338 2630 767111
SGTC_1389 3405-0187 19 µM -0.143918521885657 0.433344915688299 no 1916 0.442782404800195 2721 799890
SGTC_1103 duloxetine 36.1 µM -0.145051626079853 0.43289508036434 no 1917 0.442335055524891 2819 60835 A selective serotonin reuptake inhibitor.
SGTC_1534 6-azauridine 81.6 µM -0.146272479312346 0.432410506534655 no 1918 0.441853145245978 2645 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1472 k841-0093 193 µM -0.146741784818387 0.432224259581406 no 1919 0.441667918034226 2772 X1472
SGTC_1153 4055-0057 267 µM -0.147773139689625 0.43181501264115 no 1920 0.441260903999119 2671 882706
SGTC_2716 st080858 38.6235 µM -0.149042636566717 0.431311370223637 no 1921 0.440759994776803 2758 5296050
SGTC_1897 st060201 15 µM -0.149271903977754 0.431220425760574 no 1922 0.440669542120858 2701 611878
SGTC_2724 maprotiline 69.64 µM -0.150126228571045 0.43088156939764 no 1923 0.440332513539052 2691 4011 A tricyclic antidepressant.
SGTC_3164 9100705 49.47 µM -0.150527527827229 0.430722416990216 no 1924 0.440174217048215 2820 17174235
SGTC_10 0279-0212 42.575 µM -0.151313623505422 0.430410689709762 no 1925 0.439864161507647 2697 39851 YBR002C RER2
SGTC_2594 a-mangostin 100 µM -0.151374154279313 0.430386687946943 no 1926 0.439840288202974 2823 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1917 st066507 28.5 µM -0.152147233943179 0.430080167765218 no 1927 0.439535405266026 2679 3156428
SGTC_812 4251-0442 148 µM -0.154036917460296 0.429331100413987 no 1928 0.438790313510598 2665 5723007
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.154153609696607 0.429284852120977 no 1929 0.438744309489801 2663 91467 include heat shock
SGTC_2841 9004761 38.96 µM -0.15447274321559 0.429158375825011 no 1930 0.438618500506078 2700 2991039
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.155009524339369 0.428945659681901 no 1931 0.438406904364241 2791 551469
SGTC_1739 st037196 92.5 µM -0.156699425508035 0.428276119035983 no 1932 0.437740869932746 2780 612214
SGTC_503 tyrphostin 8 294 µM -0.156779294316538 0.428244480022153 no 1933 0.437709395887431 2755 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2223 6903751 107.57 µM -0.157068578963752 0.428129887446587 no 1934 0.437595400265416 2790 5598863
SGTC_1839 st053978 48 µM -0.15787181889648 0.427811736681987 no 1935 0.437278902407492 2682 3788398
SGTC_1418 3966-3099 2.4 µM -0.158634464740264 0.427509708027521 no 1936 0.436978436836367 2733 740335
SGTC_1290 0986-0249 10.2 µM -0.158977439686655 0.427373894385944 no 1937 0.436843324142622 2730 53329
SGTC_1407 3909-7909 12.3 µM -0.160297933414447 0.426851076450285 no 1938 0.43632319336137 2698 4411780
SGTC_1932 st074806 40.9 µM -0.161289452229038 0.426458592672967 no 1939 0.435932715199296 2930 17251235
SGTC_492 tmb-8 126 µM -0.161952165430107 0.426196304206489 no 1940 0.435671761465861 2705 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1972 st070201 17.4 µM -0.163236389368824 0.425688127391344 no 1941 0.435166157934899 2792 2829099
SGTC_1211 1056-0033 32.3 µM -0.163415428300759 0.425617290157541 no 1942 0.435095678069751 2703 6741922
SGTC_1605 st000082 49.1 µM -0.164320717714518 0.425259146776973 no 1943 0.434739336496001 2822 1114022
SGTC_2785 7756463 72.73 µM -0.165027470209114 0.424979589838903 no 1944 0.434461180193703 2723 2201551
SGTC_2568 diosmetin 100 µM -0.166118068648928 0.424548276165465 no 1945 0.434032017494384 2720 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1112 tnp00069 1.16933 µM -0.166350860256587 0.424456222609828 no 1946 0.433940421441346 2816 145826
SGTC_3184 9108758 49.47 µM -0.166940418831909 0.424223109954455 no 1947 0.433708464873268 2674 902885
SGTC_2661 dactinomycin 12.96 µM -0.167312925528276 0.424075833712177 no 1948 0.433561917196621 2698 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1732 st034308 51.822 µM -0.168546665174628 0.423588131616906 no 1949 0.433076617614286 2650 830119
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.168764495062103 0.423502034747284 no 1950 0.432990943259395 2693 364106
SGTC_638 3970-0837 4.09 µM -0.169246979941812 0.423311346479508 no 1951 0.432801189055563 2734 4118451 YLR208W SEC13
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.171066587388366 0.422592360949561 no 1952 0.432085703983297 2729 688801
SGTC_3224 9130643 49.47 µM -0.171722062576193 0.422333424621458 no 1953 0.431828020018272 2883 17644395
SGTC_2880 9042983 58.44 µM -0.171753775845812 0.422320897587053 no 1954 0.431815553460216 2857 6464714
SGTC_3113 9123498 49.47 µM -0.174539418579906 0.421220850952101 no 1955 0.430720777311375 2685 8897275
SGTC_2991 9074669 71.4286 µM -0.175708000255461 0.420759562107787 no 1956 0.430261674899762 2877 17333109
SGTC_2679 rapamycin 1 nM -0.175891237390555 0.420687240474062 no 1957 0.430189694788627 2772 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2676 harmalol 100 µM -0.176324036719192 0.420516430085649 no 1958 0.430019689646288 2736 5459187 A monoamine oxidase inhibitor
SGTC_1546 5-methoxyflavanone 78.7 µM -0.176382174481104 0.420493486333497 no 1959 0.429996853910746 2799 147795
SGTC_1989 st071868 50.2 µM -0.176847265287746 0.420309950501446 no 1960 0.429814180896345 2859 16414057
SGTC_2793 7325131 81.82 µM -0.178561684208494 0.419633550190943 no 1961 0.429140941226078 2804 4176441
SGTC_3063 1327-0034 4 µM -0.18040117671089 0.41890806784803 no 1962 0.428418815299626 2739 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1844 rapamycin 4 nM -0.181903273902129 0.418315856084037 no 1963 0.427829317581201 2701 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_532 1548-0774 215 µM -0.1822461703988 0.41818069277464 no 1964 0.427694770457134 2941 5932993
SGTC_1628 st004252 77.7 µM -0.183170598587113 0.417816348858067 no 1965 0.42733208149002 2879 692968
SGTC_3278 9139605 49.47 µM -0.183791103617642 0.417571829398 no 1966 0.427088667768881 2946 7958859
SGTC_613 3914-0030 117 µM -0.185268456548791 0.416989784400756 no 1967 0.426509238868217 2679 1145395
SGTC_1137 ixabepilone 100 µM -0.185576109516412 0.416868598648714 no 1968 0.426388594975531 2719 154225 A novel microtubule stabilizer.
SGTC_2723 salbutamol 83.58 µM -0.186167998890654 0.416635473249289 no 1969 0.426156509207758 2837 9884233 β2-adrenoceptor agonist
SGTC_1164 k060-0068 93.7 µM -0.18625688549864 0.416600466321516 no 1970 0.426121658082702 2728 5963676
SGTC_2621 lithochol-11-enic acid 100 µM -0.187042826848133 0.416290961528452 no 1971 0.425813527233376 2756 6708711
SGTC_3192 9110362 49.47 µM -0.187636216853029 0.416057318094571 no 1972 0.425580916759568 2691 16649480
SGTC_1776 st049249 45.9 µM -0.188375740967202 0.41576617684032 no 1973 0.425291057581801 2781 1822314
SGTC_903 1134-0042 114 µM -0.188413966041268 0.41575112936913 no 1974 0.425276076220541 2748 701009
SGTC_181 1447-1644 8.07 µM -0.189074199894513 0.415491244874213 no 1975 0.425017331127525 2810 534600
SGTC_3040 9091894 49.47 µM -0.190548010676598 0.414911249738458 no 1976 0.424439862598421 2756 25236966
SGTC_1343 1487-0095 224 µM -0.190929391734069 0.414761193347832 no 1977 0.424290456235588 2753 4560101 YGL055W OLE1
SGTC_1478 0453-0656 35.7 µM -0.19306376809889 0.413921641856598 no 1978 0.423454513825854 2757 5258496
SGTC_2090 5301565 104.445 µM -0.193430997918031 0.413777232490965 no 1979 0.42331072049761 2772 2056344
SGTC_755 1995-0008 37.3 µM -0.19408559044192 0.41351984961197 no 1980 0.423054432128477 2738 689533
SGTC_1555 citronellol 128 µM -0.19471263856318 0.41327333191033 no 1981 0.42280895857181 2788 8842 A terpine precursor.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.194965484225533 0.413173937831992 no 1982 0.422709984332562 2740 368090
SGTC_1976 st070609 63.5 µM -0.195221791813659 0.413073188544148 no 1983 0.422609659932146 2691 682556
SGTC_2953 9074162 66.49 µM -0.195626137154158 0.412914260275426 no 1984 0.422451400523537 2861 16451992
SGTC_2134 5324836 1.464 µM -0.196150196473107 0.412708299569143 no 1985 0.422246304095163 2798 699272
SGTC_2931 9014674 55.67 µM -0.196685976208334 0.41249775746082 no 1986 0.422036642546437 2781 2996810
SGTC_3 0833-0587 95.581 µM -0.196713777972886 0.412486833056825 no 1987 0.422025763750826 2794 5382644
SGTC_1706 st031321 9.9705 µM -0.198487137123459 0.411790151106744 no 1988 0.421331973819119 2858 6103185
SGTC_1751 st044839 27.194 µM -0.198494907773139 0.411787098939085 no 1989 0.421328934249603 2708 5291326
SGTC_2458 5808907 16.39 µM -0.198710102500454 0.411702576546237 no 1990 0.42124476048284 2800 2731747
SGTC_623 k072-0108 16.9 µM -0.199091913545458 0.411552622069169 no 1991 0.421095423333788 2854 5382803
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.200031984791918 0.411183468648896 no 1992 0.420727783181706 2803 676296 Flavone; oxidizing agent.
SGTC_1713 st033146 12.748 µM -0.200601117085881 0.410960016190494 no 1993 0.420505242259833 2869 674619
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.201461188951108 0.41062239001053 no 1994 0.420168986982673 2865 7104
SGTC_1965 Pectolinarigenin 58.4 µM -0.201703507061568 0.410527278581772 no 1995 0.42007426035765 2780 5320438 An anti-inflammatory.
SGTC_2961 9083290 32.55 µM -0.202075953437126 0.410381101225992 no 1996 0.419928673218932 2793 17741490
SGTC_2760 etidronate 98.04 µM -0.206714422067213 0.408561649278546 no 1997 0.418116446742996 2802 3305 A chelator and antioxidant.
SGTC_1934 st074720 32.6 µM -0.207944784550037 0.408079365060272 no 1998 0.417636040190076 2770 17250992
SGTC_2319 6033012 152.6 µM -0.208143151508397 0.408001621108736 no 1999 0.417558597439638 2786 847246
SGTC_976 1348-1067 47.6 µM -0.209181607668468 0.407594688688778 no 2000 0.417153234887449 2788 5310671 YGL099W LSG1
SGTC_565 1418-0001 44.5 µM -0.209516298871425 0.407463556851212 no 2001 0.417022606534001 2946 2862145
SGTC_685 1278-0033 54.9 µM -0.210649710402894 0.407019563902279 no 2002 0.416580309623787 2901 3590572
SGTC_3248 9135562 49.47 µM -0.211363424300989 0.406740040978577 no 2003 0.41630184758618 2819 17650701
SGTC_834 0312-0008 75.7 µM -0.211936832715764 0.406515502491397 no 2004 0.416078157445465 2763 6385573 YIL048W NEO1
SGTC_97 0535-0701 19.132 µM -0.214566297824583 0.405486236479334 no 2005 0.415052736177193 2803 2832013 YGL099W LSG1
SGTC_2402 5553605 200 µM -0.214624483763531 0.405463467797847 no 2006 0.415030051728672 2972 6758546
SGTC_3029 9088683 49.47 µM -0.214754631946716 0.405412540800748 no 2007 0.41497931300828 2921 25236615
SGTC_2932 9016711 44.54 µM -0.21487953360612 0.405363668274679 no 2008 0.414930620996885 2889 7117328
SGTC_1417 3966-0327 90.4 µM -0.215290061851325 0.405203043879287 no 2009 0.414770588730734 2829 651118
SGTC_2576 guaiol 23.12 µM -0.215877227446301 0.404973335630247 no 2010 0.414541724217522 2943 227829
SGTC_1427 4048-4900 550 nM -0.216184243559961 0.404853239214292 no 2011 0.414422067487851 2913 24132586
SGTC_1067 clotrimazole 1.36 µM -0.21677774568106 0.404621102621342 no 2012 0.414190777974529 2790 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1711 st032263 62.8 µM -0.217021723666921 0.404525685198351 no 2013 0.414095707665175 2835 3958979
SGTC_558 k064-0027 21.3 µM -0.217804909086643 0.404219427374074 no 2014 0.413790559745333 2908 5088526
SGTC_911 3456-4043 236 µM -0.218601457009453 0.403908004459182 no 2015 0.413480258861008 2880 914281
SGTC_3091 9116372 49.47 µM -0.218683438546565 0.403875955943397 no 2016 0.413448325435867 2954 17169793
SGTC_68 0986-0284 82.829 µM -0.220254707141627 0.403261834945798 no 2017 0.412836396213368 2988 423278 YIL048W NEO1
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.221269539908909 0.402865320253442 no 2018 0.412441282903186 2814 756377
SGTC_792 4534-1957 155 µM -0.22168868128654 0.402701582772078 no 2019 0.412278120957172 2849 1717904
SGTC_119 0121-0043 24.815 µM -0.221809082652975 0.402654551160154 no 2020 0.412231254319837 2787 1092378
SGTC_2833 9001315 45.46 µM -0.222380554625579 0.402431339959164 no 2021 0.412008824009663 2821 2989378
SGTC_2168 5727979 200 µM -0.222616081129956 0.402339354928665 no 2022 0.411917159785228 2743 695210
SGTC_1942 st076330 65.2 µM -0.222851387950777 0.402247461095657 no 2023 0.411825585858411 2965 24208414
SGTC_1998 st075797 76.8 µM -0.222955114458856 0.402206954735667 no 2024 0.411785220326835 2762 24208315
SGTC_3353 9151644 39.2805 µM -0.223187538480201 0.40211619437286 no 2025 0.411694775100101 2921 4909158
SGTC_935 2996-0153 430 µM -0.227537854169638 0.400418397818085 no 2026 0.410002768840683 2984 23738523
SGTC_649 1123-0311 367 µM -0.228297895673599 0.400121968629883 no 2027 0.409707330188819 2909 693629 YIL048W NEO1
SGTC_757 1066-0008 322 µM -0.229026655348495 0.399837793918822 no 2028 0.409424099352473 2969 6842497
SGTC_1946 st076057 65.1 µM -0.229209797837893 0.399766387126624 no 2029 0.409352928855439 2793 953009
SGTC_2432 5630864 12.22 µM -0.229609681264401 0.39961048524556 no 2030 0.409197541647572 2967 5714970
SGTC_1316 1272-0050 65.9 µM -0.229691693140963 0.399578513389711 no 2031 0.40916567513103 2803 7340392
SGTC_2341 7987486 176.74 µM -0.230104753902988 0.39941749428093 no 2032 0.40900518546263 2955 1258686
SGTC_465 cgp-37157 41 µM -0.232221987112808 0.398592424795588 no 2033 0.408182800620184 2906 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1795 st049545 62.3 µM -0.232431960595662 0.398510624378205 no 2034 0.408101263791466 2806 5291882
SGTC_2992 9074591 71.4286 µM -0.23316251639255 0.39822605287796 no 2035 0.407817605652036 2920 17741321
SGTC_1733 st037357 54.9 µM -0.234307583250265 0.397780126909407 no 2036 0.407373099594021 2778 1272339 YGL099W LSG1
SGTC_1950 st077106 7.18 µM -0.236080920378719 0.397089795926926 no 2037 0.406684939429065 2917 13831864
SGTC_542 3381-0244 89.3 µM -0.236244223057131 0.397026241053836 no 2038 0.40662158274019 3011 1112843
SGTC_385 1494-0393 12.4 µM -0.23678204681281 0.39681694772066 no 2039 0.406412940057062 2865 3090647
SGTC_1647 st011722 22.4 µM -0.23765205300015 0.396478449022084 no 2040 0.406075487207296 2993 2854783
SGTC_1240 0356-0016 42.1 µM -0.238597775630686 0.396110579354503 no 2041 0.40570874505534 2879 4305613
SGTC_2121 5257820 149.641 µM -0.240700740566384 0.395292894499409 no 2042 0.404893532476836 2977 791256
SGTC_3305 9127027 53.8275 µM -0.241192184121848 0.395101875365756 no 2043 0.404703084141904 2869 41905295
SGTC_1288 0973-0013 65.5 µM -0.241271365875265 0.395071100576681 no 2044 0.40467240107401 2915 4315430
SGTC_2886 9058944 51.95 µM -0.241560233608081 0.394958834762545 no 2045 0.404560469293764 2846 4949929
SGTC_1522 st012842 45.6 µM -0.246307114367098 0.393115258328159 no 2046 0.402722251549126 2777 3491067 YOR116C RPO31
SGTC_3181 9108277 49.47 µM -0.246531769175753 0.39302806672654 no 2047 0.402635307462067 2860 17097298
SGTC_3252 9135871 49.47 µM -0.249153731838209 0.392010845074583 no 2048 0.401620933811887 2986 17682838
SGTC_896 0964-0007 44.5 µM -0.251531580587053 0.391088967902 no 2049 0.400701574530557 2822 6756758
SGTC_625 k213-0058 121 µM -0.25215741978962 0.390846435391035 no 2050 0.400459694442715 2906 3655420
SGTC_2857 9024691 58.44 µM -0.253760204998562 0.390225499147623 no 2051 0.399840409535655 2954 16478292
SGTC_1721 st082152 9.2685 µM -0.256878071835481 0.389018407229636 no 2052 0.398636449421205 2800 5296051
SGTC_2603 homopterocarpin 100 µM -0.257065162017858 0.388946008608214 no 2053 0.39856423534279 2992 101795 A weak amylase inhibitor.
SGTC_854 0422-0053 192 µM -0.258251616161187 0.388486974198913 no 2054 0.398106362314102 2874 3596728
SGTC_1199 1638-0010 4.46 µM -0.261456447520268 0.387247817594135 no 2055 0.396870265753162 2850 3111136
SGTC_1262 0737-0114 49.6 µM -0.261701198321284 0.387153231070536 no 2056 0.396775908298599 3011 765919
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.263331934988357 0.386523187010614 no 2057 0.396147373732406 2852 1241132 A phosphatase inhibitor.
SGTC_311 1315-0136 58 µM -0.263826385946252 0.386332212171446 no 2058 0.395956850824006 3052 6759207
SGTC_696 1560-0013 611 µM -0.264706761294764 0.385992247557406 no 2059 0.395617684243462 3077 1650269
SGTC_3160 9100216 49.47 µM -0.265780314170873 0.385577804226175 no 2060 0.39520420255596 2841 17191039
SGTC_1271 0832-2808 169 µM -0.265803086689402 0.385569014345632 no 2061 0.395195432937204 3025 3663794
SGTC_2292 7671323 168.05 µM -0.265826130788541 0.385560119698514 no 2062 0.395186558787723 3029 937504
SGTC_2739 tacrine 100.86 µM -0.26730129357526 0.384990856310158 no 2063 0.394618595431582 2978 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2954 9074818 52.69 µM -0.268915480748314 0.384368227543919 no 2064 0.393997361866205 3046 16648742
SGTC_1424 4048-1941 275 µM -0.269057524403024 0.384313452323089 no 2065 0.393942708050408 3009 X1424
SGTC_2332 7982454 138.89 µM -0.269973344986402 0.383960346861563 no 2066 0.393590380027322 2954 2981748
SGTC_3061 glucosamine 200 µM -0.27098953222725 0.383568656575312 no 2067 0.393199541607541 2964 91431 and experimental redox chemotherapeutic
SGTC_2361 9034121 116 µM -0.271592485233752 0.383336303999439 no 2068 0.392967689127411 2915 6496917
SGTC_1010 4112-3296 15.2 µM -0.272386828293127 0.383030261853463 no 2069 0.392662299725948 3047 704384
SGTC_1729 st035615 45.989 µM -0.272613246605499 0.382943041436374 no 2070 0.392575264097457 2998 17385451
SGTC_2764 methyldopa 94.69 µM -0.272662860416207 0.382923930094354 no 2071 0.392556193171975 3060 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_487 nimodipine 119 µM -0.274268414717996 0.382305621368147 no 2072 0.391939177776793 2960 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2524 avocatin b 10.57 µM -0.275071724900166 0.38199637422177 no 2073 0.391630567100003 2994 6710748
SGTC_2693 st077581 40.7 µM -0.277308759378892 0.381135589158305 no 2074 0.390771517103392 3016 25238761
SGTC_1320 1313-0481 95.3 µM -0.278205833333859 0.380790570323829 no 2075 0.390427178603907 3068 6813365 YLR208W SEC13
SGTC_399 oxolinic acid 75 µM -0.279777384374468 0.380186373042537 no 2076 0.38982415185973 2888 4628 A DNA gyrase inhibitor.
SGTC_2791 5663188 71.43 µM -0.27992799969084 0.380128482919747 no 2077 0.38976637249422 3063 54690634
SGTC_1853 st056710 91.2 µM -0.280023796869623 0.380091663955032 no 2078 0.389729623845695 3060 269167
SGTC_2744 captopril 92.04 µM -0.28026484150961 0.379999024968838 no 2079 0.389637161342703 2993 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3151 9099821 49.47 µM -0.280607252876421 0.379867440261386 no 2080 0.389505826237072 3028 17174189
SGTC_164 4100-3994 89.624 µM -0.281214051707761 0.37963428869455 no 2081 0.389273113832295 2995 4615967
SGTC_2802 7925815 54.55 µM -0.281285582079772 0.379606807313545 no 2082 0.389245683953678 2887 1262923
SGTC_2310 7668677 200 µM -0.283144275079096 0.378892926331394 no 2083 0.38853312152142 3119 2197143
SGTC_694 1315-0438 43.2 µM -0.283511748772961 0.378751837000278 no 2084 0.388392288377213 2940 6793154
SGTC_847 0342-0274 5.54 µM -0.284132124730532 0.378513684025758 no 2085 0.388154564532511 3030 18097
SGTC_941 3237-0776 460 µM -0.284352163205977 0.37842922565196 no 2086 0.38807025734806 3110 760008
SGTC_1401 3807-4679 7.6 µM -0.285820162765501 0.377865905465504 no 2087 0.387507932202588 2907 3291456
SGTC_1898 st060199 18.6 µM -0.290923519341257 0.375909605123815 no 2088 0.385554906547886 2904 688866
SGTC_2924 9010168 62.78 µM -0.291961953706351 0.375511924193959 no 2089 0.385157856860095 3018 2993929
SGTC_2326 6164455 177.58 µM -0.292849959253369 0.375171956659562 no 2090 0.384818419710097 2992 2888790
SGTC_2364 9055074 200 µM -0.293089232114704 0.375080369065954 no 2091 0.384726973543809 3007 6470630
SGTC_2887 9044784 58.44 µM -0.29689653066401 0.373623982422861 no 2092 0.383272752472913 2936 6465546
SGTC_1913 st060213 96.1 µM -0.297052253040063 0.373564452969515 no 2093 0.38321330819594 3106 688959
SGTC_2896 9052656 71.43 µM -0.297064222973896 0.373559877235472 no 2094 0.383208738998108 3041 6469436
SGTC_2349 9023730 187.07 µM -0.297395955821077 0.373433073162669 no 2095 0.383082115441011 3079 4126287
SGTC_2916 7875993 68.79 µM -0.297656339531209 0.373333551722505 no 2096 0.38298273484224 2974 1299250
SGTC_173 1273-0061 2.693 µM -0.29998737407113 0.37244298248618 no 2097 0.382093393195597 3038 2847414 YPL266W DIM1
SGTC_29 0299-0004 12.984 µM -0.300797138966959 0.372133771955067 no 2098 0.381784595102934 2974 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1245 0418-0076 17.2 µM -0.301018418853898 0.372049290069233 no 2099 0.381700224665218 3103 6790114
SGTC_545 4218-0007 221 µM -0.301429633561793 0.371892309811389 no 2100 0.38154345008401 3053 2840508
SGTC_2149 5554786 194.827 µM -0.301947755517864 0.371694548281201 no 2101 0.381345945049856 2947 745063 YPR165W RHO1
SGTC_2838 9002687 71.43 µM -0.302262810347402 0.371574311818808 no 2102 0.381225863109296 2906 6457060
SGTC_1682 st012968 530 nM -0.304104506111141 0.370871704283949 no 2103 0.380524136972028 2941 24207270
SGTC_1893 st059353 36.1 µM -0.304415056345551 0.370753271603196 no 2104 0.380405849232152 3005 3112488
SGTC_13 0199-0087 65 µM -0.306168697561632 0.370084726064205 no 2105 0.379738102214505 2932 4589825
SGTC_1882 5615643 20 µM -0.307029506906999 0.369756700748607 no 2106 0.379410456469161 2985 2253075
SGTC_874 0599-0792 117 µM -0.307985764984496 0.36939241425078 no 2107 0.37904658205525 3114 765305
SGTC_360 0957-0399 1.01 µM -0.308735575229084 0.36910685603306 no 2108 0.378761339907298 3088 6752301 YPR165W RHO1
SGTC_1816 st051957 91.6 µM -0.310262519029235 0.368525557212614 no 2109 0.378180665587063 2980 674121
SGTC_2328 6201408 200 µM -0.310761007095981 0.36833585069463 no 2110 0.377991157380358 3082 2890418
SGTC_3094 9117742 49.47 µM -0.310847842861721 0.368302807425806 no 2111 0.37795814837692 2908 17149698
SGTC_40 0327-0103 19.753 µM -0.310856068962846 0.368299677230745 no 2112 0.377955021423568 2978 409036
SGTC_1569 carminic acid 40.6 µM -0.310887848807248 0.368287584450103 no 2113 0.377942941159595 3123 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2369 9071472 200 µM -0.310902384403569 0.3682820534477 no 2114 0.377937415878407 3091 17296037
SGTC_706 4262-0057 46.9 µM -0.312380508618854 0.367719748748419 no 2115 0.377375680810232 2968 883298
SGTC_2582 agaric acid 100 µM -0.312396919384002 0.367713507390551 no 2116 0.377369445641484 3071 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_980 1473-0395 201 µM -0.312811442125548 0.367555867295447 no 2117 0.377211960894111 2944 768876
SGTC_2002 4023503 131 µM -0.313368784657378 0.36734394900833 no 2118 0.37700024849305 3094 4736863 YCR052W RSC6
SGTC_3294 9122953 26.2835 µM -0.313786965184982 0.367184970797252 no 2119 0.376841422512341 2942 16459826
SGTC_1845 st056753 3.01 µM -0.314816682453284 0.366793603933264 no 2120 0.376450422279494 2903 5375839
SGTC_3161 9100388 49.47 µM -0.315177151279242 0.366656632458849 no 2121 0.376313576388197 2984 25236368
SGTC_3038 9091290 49.47 µM -0.315457288985668 0.366550197045222 no 2122 0.376207237582171 3121 25236843
SGTC_607 4491-0986 66.8 µM -0.316786904302699 0.36604516357576 no 2123 0.375702650843712 3103 698981 YDR232W HEM1
SGTC_754 3474-0146 171 µM -0.317871860040483 0.365633232040033 no 2124 0.375291069397891 2951 24762078
SGTC_2687 chenodiol 100 µM -0.319770554782823 0.364912716412554 no 2125 0.374571135210041 3065 5702181 A cholesterol synthesis inhibitor.
SGTC_169 k015-0017 16.025 µM -0.320459084539667 0.364651551181008 no 2126 0.374310171008979 3208 1840002
SGTC_157 1348-1695 65.819 µM -0.320625084390379 0.364588595407782 no 2127 0.374247262920957 2958 5380510
SGTC_3326 9140064 16.379 µM -0.321082666451317 0.364415075414186 no 2128 0.37407387279984 2949 1868434
SGTC_2823 7987624 58.44 µM -0.32380482485579 0.363383379279693 no 2129 0.373042901567189 3208 2239440
SGTC_922 1866-0035 480 µM -0.324901944384939 0.362967851276671 no 2130 0.372627642627286 2963 3156169
SGTC_2712 st079126 47.7 µM -0.325241037620566 0.362839454177148 no 2131 0.372499326004345 2965 3152970
SGTC_386 1509-0011 3.07 µM -0.326021670131904 0.362543927578613 no 2132 0.37220397985448 2970 3107280
SGTC_2105 5350118 200 µM -0.32839120926057 0.361647385527656 no 2133 0.371307944396754 2999 2133313
SGTC_805 3852-0218 479 µM -0.328640305550843 0.361553181118758 no 2134 0.371213789647935 2961 6615355
SGTC_467 ro 31-8220 72.8 µM -0.328959244709974 0.361432575455859 no 2135 0.371093246570538 3012 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2757 clomiphene 4.22 µM -0.329153310672149 0.361359196866983 no 2136 0.371019905514559 3203 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_15 0266-0086 27.098 µM -0.329388868552897 0.361270136555111 no 2137 0.37093089020247 3079 1712902 YIL048W NEO1
SGTC_378 3970-0959 8.33 µM -0.329573086373687 0.361200492259892 no 2138 0.370861280673087 3114 6615653
SGTC_55 0767-0285 6.563 µM -0.330950392484552 0.360679942002606 no 2139 0.370340978489606 3088 3116166
SGTC_2443 5493264 126.67 µM -0.331999997887339 0.360283418802823 no 2140 0.369944630301005 3136 5340055
SGTC_2123 5259487 200 µM -0.332124572885408 0.360236366437866 no 2141 0.369897597901556 3110 2173474
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.33286214589058 0.359957826208835 no 2142 0.369619172378196 2950 5355888
SGTC_1077 5-fluorocytosine 377 nM -0.334123013071659 0.359481839172545 no 2143 0.369143367543121 3060 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1664 st014217 9.02 µM -0.334432584076755 0.359365007038416 no 2144 0.369026577464383 3044 3982782
SGTC_124 0136-0217 7.121 µM -0.335412338610617 0.358995334254973 no 2145 0.368657030820201 3159 3976905
SGTC_1650 st011916 45.8 µM -0.336990929829599 0.358399991234234 no 2146 0.368061868782941 3128 242528
SGTC_364 0083-0097 67.7 µM -0.337259207426977 0.358298848350101 no 2147 0.367960753926448 3126 5207356
SGTC_129 0088-0017 176.636 µM -0.337464231373616 0.358221559319566 no 2148 0.367883485780625 3133 182446
SGTC_268 camptothecin 39.6153 µM -0.337539305948636 0.358193259487551 no 2149 0.367855193480203 3086 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_741 4582-0002 126 µM -0.339491670912725 0.35745757724043 no 2150 0.367119685288907 2985 2912688
SGTC_3171 9103192 49.47 µM -0.339889045450142 0.357307904932452 no 2151 0.36697004326323 3096 13018434
SGTC_1027 k015-0025 8.67 µM -0.340226902484225 0.357180667333758 no 2152 0.366842830042803 2966 3598955
SGTC_296 1222-0039 74.9 µM -0.34259861535325 0.356287923501931 no 2153 0.365950221943135 3043 5984176
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.342661048412654 0.356264433490687 no 2154 0.365926734667809 3137 5024745
SGTC_654 1124-0271 80.9 µM -0.343401147162169 0.355986017978354 no 2155 0.36564834831638 3029 5403748
SGTC_1230 0170-0365 3.77 µM -0.344375668927193 0.355619532707931 no 2156 0.365281892240518 3127 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_942 3253-1115 227 µM -0.34576453493379 0.355097456979666 no 2157 0.364759840042578 3211 46497897
SGTC_2750 bromebric acid 70.15 µM -0.345965644616727 0.355021882219647 no 2158 0.364684266928909 3176 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1820 st053765 18.6 µM -0.348011879698994 0.354253254762394 no 2159 0.363915630901433 3085 3690829
SGTC_253 dyclonine 31.25 µM -0.348404346470345 0.354105900155414 no 2160 0.363768269380921 3032 3180 An oral anasthetic.
SGTC_3150 9097574 49.47 µM -0.350981892298772 0.353138684902855 no 2161 0.362800966579925 3189 17217476
SGTC_3260 9137109 49.47 µM -0.351504908817855 0.352942540237931 no 2162 0.362604795223962 3086 17478346
SGTC_1416 3966-0321 25.3 µM -0.352162725669164 0.352695897458235 no 2163 0.362358114598751 3067 582530 YLR208W SEC13
SGTC_1346 1488-2224 62.4 µM -0.352694339799156 0.352496618528147 no 2164 0.362158801603862 3141 3722427
SGTC_2311 7694451 200 µM -0.352767559144165 0.352469174962362 no 2165 0.362131353102607 3064 2163142
SGTC_212 3807-4682 38.772 µM -0.352894580401605 0.352421567559702 no 2166 0.362083736997901 3099 3125501 YBL034C STU1
SGTC_3066 9117245 49.47 µM -0.3531371380308 0.352330663697856 no 2167 0.361992816025457 3061 17176980
SGTC_208 k072-0098 12.366 µM -0.353643325833068 0.352140985744744 no 2168 0.36180310027901 3028 5948901
SGTC_445 e6 berbamine 66 µM -0.354508362010193 0.351816925805034 no 2169 0.361478969226449 3115 6610268 A calcium/calmodulin antagonist.
SGTC_103 0844-0104 51.839 µM -0.356348947989297 0.351127763668767 no 2170 0.360789628380085 3144 5375804
SGTC_2906 7926292 26.41 µM -0.356382919682949 0.35111504839607 no 2171 0.360776909458598 3159 2966319
SGTC_1499 4480-0877 67.3 µM -0.356703950703447 0.350994897856626 no 2172 0.360656723811318 3028 2861909
SGTC_344 k064-0035 6.43 µM -0.357038213540063 0.350869810946716 no 2173 0.360531599141654 3025 5088750
SGTC_2863 9028737 58.44 µM -0.357452104819049 0.350714948098427 no 2174 0.360376687835174 3100 6460917
SGTC_1009 4106-0057 9.87 µM -0.358952712537552 0.350153684183294 no 2175 0.359815232428436 3195 2928005
SGTC_2768 sulfasalazine 50.2 µM -0.359991854361526 0.349765211399961 no 2176 0.359426612527087 3183 5384001 An antioxidant and salicylic acid derivative.
SGTC_2095 5432005 200 µM -0.360513457789197 0.349570274416557 no 2177 0.359231597220487 3033 783734
SGTC_3314 9135860 59.4275 µM -0.360915777263065 0.349419944088651 no 2178 0.359081204437125 3185 25252478
SGTC_1514 1189-1591 158 µM -0.36118257065494 0.349320267334508 no 2179 0.35898148528492 3215 767698 YMR146C TIF34
SGTC_992 3909-8734 162 µM -0.361452871025339 0.349219290934175 no 2180 0.358880465131065 3073 4288319
SGTC_2433 5607874 27.82 µM -0.361778584468773 0.349097627991857 no 2181 0.358758748398279 3028 2252428
SGTC_2214 7179297 48.276 µM -0.362979971467491 0.348649011038624 no 2182 0.358309922954917 3064 769744
SGTC_1623 st003709 20.3 µM -0.363708493302364 0.348377072435429 no 2183 0.358037850195181 3028 16192618
SGTC_480 am 92016 50 µM -0.365300654090481 0.347783030842038 no 2184 0.35744349510127 3113 2129 K+ channel blocker.
SGTC_1364 1653-0028 37.6 µM -0.365863350214114 0.347573175901186 no 2185 0.357233522701427 3096 5718652
SGTC_2205 7238770 200 µM -0.367390595513318 0.347003832325539 no 2186 0.356663842788041 3179 279867
SGTC_3209 9113616 49.47 µM -0.367393541945176 0.347002734254975 no 2187 0.356662744043832 3256 16649353
SGTC_1675 st018485 24.5 µM -0.367704025537374 0.346887031028788 no 2188 0.356546969296968 3079 3323024
SGTC_2441 5730946 39.09 µM -0.367923821215321 0.34680513172606 no 2189 0.356465018723565 3189 1774275
SGTC_502 l-744,832 89.3 µM -0.368275345553935 0.34667416314586 no 2190 0.35633396704193 3154 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2659 sanguinarine 24.21 µM -0.368744205837156 0.346499506844973 no 2191 0.356159197788512 3033 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2098 5376439 882.5 nM -0.371259240241273 0.345563182917655 no 2192 0.355222226758639 3157 2844116
SGTC_363 0455-0021 3.06 µM -0.372144277491081 0.345233916041635 no 2193 0.354892715647628 3036 4597466
SGTC_627 1391-0720 175 µM -0.373435644654202 0.344753689439196 no 2194 0.35441211725348 3129 997839
SGTC_2069 5228469 200 µM -0.373510386218269 0.344725902599767 no 2195 0.354384308335203 3162 2835210
SGTC_162 k030-0015 37.8 µM -0.373522384132226 0.344721442186322 no 2196 0.354379844371832 3132 1809920 YMR134W ERG29
SGTC_2753 fluvastatin 17.09 µM -0.374471856651549 0.344368529314166 no 2197 0.354026645562009 3132 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2720 fluspirilene 36.88 µM -0.374695880295081 0.344285280896019 no 2198 0.353943328235779 3143 3396 An atypical antipsychotic.
SGTC_101 0490-5701 117.494 µM -0.375029309761214 0.344161390643684 no 2199 0.353819334403166 3146 4661669
SGTC_2971 9092186 9.93 µM -0.375133317280195 0.344122748657059 no 2200 0.353780659856879 3019 25236400
SGTC_1335 1486-0900 202 µM -0.378076888571966 0.343029797763771 no 2201 0.352686738271485 3026 X1335
SGTC_1518 st038567 90.8 µM -0.378085379350544 0.343026647022871 no 2202 0.352683584593152 3139 77966
SGTC_1398 3558-0053 112 µM -0.379667819485297 0.342439629127918 no 2203 0.352096005441944 2997 4532369
SGTC_1924 st058459 75.1 µM -0.38021152404658 0.342238025623662 no 2204 0.351894202761073 3134 688683
SGTC_657 3534-0529 86.7 µM -0.380471298852156 0.342141718018472 no 2205 0.351797798847979 3213 1049549
SGTC_1666 st014829 29 µM -0.38164704503152 0.341705956272221 no 2206 0.351361591960841 3045 3858230
SGTC_3156 9099931 49.47 µM -0.381835336917213 0.341636190034004 no 2207 0.351291753027439 3026 18111053
SGTC_2492 derrusnin 100 µM -0.382194488700151 0.341503131489761 no 2208 0.351158554745691 3000 1715307 Part of coumarin class of compounds.
SGTC_582 0987-0078 156 µM -0.383415682418122 0.341050851096703 no 2209 0.350705788642473 3230 1625765
SGTC_2586 curcumin 80 µM -0.38360561574027 0.340980528032539 no 2210 0.350635388567295 3178 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3342 9147791 14.508 µM -0.383782980822533 0.340914863363853 no 2211 0.350569651626754 3076 1838168
SGTC_2973 9094665 17.96 µM -0.384508657049372 0.340646251400318 no 2212 0.350300740379367 3274 25237061 YIL048W NEO1
SGTC_1297 1068-0111 14.1 µM -0.385003085825024 0.340463282875358 no 2213 0.350117564638349 3064 767057
SGTC_291 SEC14.278 35.5 µM -0.385171776608843 0.34040086567908 no 2214 0.350055076130938 3195 1068044
SGTC_2435 5706476 10.6 µM -0.386078575422499 0.340065416433036 no 2215 0.349719238211889 3234 5725375
SGTC_3186 9110464 49.47 µM -0.386200889530153 0.340020178839677 no 2216 0.349673947503046 3207 17018021
SGTC_1075 aripiprazole 15.2 µM -0.387123893705693 0.339678882160619 no 2217 0.349332244723883 3069 60795 An atypical antipschotic. YIL048W NEO1
SGTC_997 3996-0078 137 µM -0.387510863945364 0.339535832333276 no 2218 0.349189021864332 3128 735687
SGTC_431 k089-0097 107 µM -0.388080930246534 0.339325140188024 no 2219 0.348978071830638 3171 5499420
SGTC_1358 1509-0022 2.48 µM -0.388980247445459 0.338992861555951 no 2220 0.348645379132174 3150 3258434
SGTC_1145 3546-0597 10.2 µM -0.389323685763683 0.338866001407076 no 2221 0.348518358521366 3124 875334
SGTC_2787 5284540 71.43 µM -0.389822947341384 0.338681615446358 no 2222 0.348333736993232 3120 736958
SGTC_2150 5556613 200 µM -0.389941725861175 0.338637754169355 no 2223 0.348289819271231 3106 743190
SGTC_636 0kpi-0074 126 µM -0.393748220529767 0.337233293705664 no 2224 0.346883468216662 3151 616434
SGTC_2737 bleomycin 30.5 nM -0.393873797851059 0.337186998656841 no 2225 0.346837108097653 3147 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_225 nsc-122657 1.016 µM -0.395143039192765 0.33671922152703 no 2226 0.346368663614181 3193 275685
SGTC_537 1334-0398 209 µM -0.395221943211301 0.336690149890104 no 2227 0.346339549909212 3249 5846986
SGTC_2648 atorvastatin 78.68 µM -0.395979596618069 0.33641104745909 no 2228 0.346060040069657 3196 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_389 tpck 16.7 µM -0.396047316122859 0.336386105505748 no 2229 0.346035061396615 3168 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_11 0438-0307 1.3 µM -0.396285299791267 0.336298458811248 no 2230 0.345947285262366 3211 4011476
SGTC_596 1155-0152 116 µM -0.396409397659912 0.336252758498022 no 2231 0.345901517206692 3138 280313
SGTC_3219 9131112 49.47 µM -0.396834643381883 0.336096175753692 no 2232 0.34574470105387 3202 17612988 YMR079W SEC14
SGTC_2409 alverine citrate 63.97 µM -0.397035120059751 0.336022366675125 no 2233 0.345670781252862 3318 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_168 3970-0862 530.542 µM -0.399833487210802 0.334992758879379 no 2234 0.344639582119847 3194 3135186
SGTC_142 0335-0849 62.6745 µM -0.401278743558024 0.334461487961652 no 2235 0.344107455865879 3260 3889043 YPR107C YTH1
SGTC_2201 6605497 169.863 µM -0.401794430198885 0.334272003597721 no 2236 0.343917660790768 3133 670741
SGTC_1872 amphotericin b 148 nM -0.403036569855814 0.333815764097464 no 2237 0.3434606609708 3206 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_115 0527-0192 112.043 µM -0.40378134712411 0.333542324162359 no 2238 0.34318675708626 3210 4233931
SGTC_816 0325-0417 81.3 µM -0.403929503073468 0.333487940246099 no 2239 0.343132280157054 3182 68101
SGTC_19 0279-0214 38.434 µM -0.407123756879048 0.332316271455008 no 2240 0.34195854782644 3138 3566274 YBR002C RER2
SGTC_356 1634-0012 32.5 µM -0.407315899520346 0.332245844624283 no 2241 0.341887993324317 3242 735457
SGTC_2179 6298986 200 µM -0.407746988912611 0.332087857217671 no 2242 0.341729718012493 3235 738374
SGTC_3099 9120367 49.47 µM -0.410348485431204 0.331135084410912 no 2243 0.340775164839943 3103 24824940
SGTC_1500 4488-1866 171 µM -0.411264615332065 0.330799820479756 no 2244 0.340439256409427 3256 2900003
SGTC_1574 spiramycin 23.7 µM -0.411267924712851 0.330798609635265 no 2245 0.340438043220229 3076 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1333 1482-0047 286 µM -0.41347688777198 0.329990784231021 no 2246 0.339628626185995 3262 3811116
SGTC_2080 5212524 12.4 µM -0.415592072239189 0.329217996206692 no 2247 0.338854264389993 3254 260183
SGTC_2289 7946404 165.07 µM -0.416408779115736 0.328919805200518 no 2248 0.338555452717526 3105 1246120 YPR165W RHO1
SGTC_1539 benzyladenosine 56 µM -0.416436673334421 0.328909622555839 no 2249 0.338545248746354 3132 92208 A nucleotide analog.
SGTC_365 0121-0052 13.6 µM -0.416787797360964 0.328781457351755 no 2250 0.338416814368174 3246 3101739
SGTC_954 1189-0853 2.85 µM -0.416814963288543 0.328771542245345 no 2251 0.338406878380378 3185 2828194
SGTC_1206 3978-0017 132 µM -0.417682054886095 0.328455131751452 no 2252 0.338089797177426 3369 3873677
SGTC_2233 sulbentine 40.3845 µM -0.419466335768945 0.327804416728963 no 2253 0.337437676309385 3200 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2249 haloperidol 116.36 µM -0.420353186952571 0.327481182435551 no 2254 0.337113730408507 3156 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_966 1300-0360 30.2 µM -0.42251555493693 0.3266935975776 no 2255 0.336324374717799 3135 70588
SGTC_2490 carminic acid 95.39 µM -0.423511872885523 0.326330974798929 no 2256 0.335960918965079 3237 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2545 solidagenone 89.61 µM -0.42422369380319 0.326071998862832 no 2257 0.335701341322059 3049 6708572 An anti ulcer agent
SGTC_1387 3342-1166 1.8 µM -0.424612576008127 0.325930550472072 no 2258 0.335559561888147 3188 3418228
SGTC_3142 9086498 49.47 µM -0.425249270314347 0.325699019298489 no 2259 0.3353274851807 3218 25236367
SGTC_309 k408-0051 1.48 µM -0.425953666291212 0.325442947021654 no 2260 0.335070804247091 3211 3640463
SGTC_1213 1315-0166 115 µM -0.426064000185172 0.325402844298114 no 2261 0.335030605699263 3210 768401
SGTC_651 3253-0966 34.4 µM -0.426280867491856 0.325324026092181 no 2262 0.334951598761367 3167 781462
SGTC_736 0958-0254 92.6 µM -0.427427741201614 0.324907336542154 no 2263 0.334533902663444 3275 6812352
SGTC_2079 5212404 121 µM -0.427996123536194 0.324700909319753 no 2264 0.334326971328335 3296 758462
SGTC_75 0159-0059 199.013 µM -0.430215593280375 0.323895349980141 no 2265 0.33351941002243 3421 5377270
SGTC_1006 4099-6547 255 µM -0.43154066584991 0.323414805832121 no 2266 0.333037645268593 3276 3146833
SGTC_3076 9116187 49.47 µM -0.431778998961087 0.323328404361532 no 2267 0.332951022241558 3241 27241210
SGTC_466 geldanamycin 89.2 µM -0.434402228285768 0.322378051191317 no 2268 0.331998189959721 3180 5288382 HSP90 inhibitor.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.435111896455583 0.322121149037727 no 2269 0.331740604359613 3168 71034 A hepatoprotective.
SGTC_1220 1838-0075 193 µM -0.435447131373337 0.321999822462123 no 2270 0.331618953045878 3180 5529645
SGTC_111 0083-0039 52.457 µM -0.435775593044223 0.321880965625114 no 2271 0.331499776855963 3100 759313
SGTC_327 1273-0057 3.96 µM -0.437240708132824 0.321351022478591 no 2272 0.330968395053209 3179 3108138
SGTC_1303 1160-0052 261 µM -0.43823614170712 0.320991173962839 no 2273 0.330607555876785 3240 3562476
SGTC_266 formosanin C 406 nM -0.441199701331831 0.319920845351749 no 2274 0.329534214711093 3251 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3182 9108849 49.47 µM -0.441357535175786 0.319863883500859 no 2275 0.329477089764423 3277 17133045
SGTC_586 0957-0265 8.15 µM -0.442982756976835 0.319277592145105 no 2276 0.328889103411909 3245 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3089 9117425 49.47 µM -0.444965517426424 0.318562931994687 no 2277 0.328172336903201 3247 9401657
SGTC_1824 st053723 68.6 µM -0.445501282709044 0.318369938018712 no 2278 0.327978766511728 3231 675225
SGTC_2152 5568786 200 µM -0.447315500994626 0.317716784493322 no 2279 0.327323638215801 3243 5399883
SGTC_312 4092-0653 6.84 µM -0.448340848516127 0.317347890213036 no 2280 0.32695361221552 3271 1148278
SGTC_301 4119-0100 24.5 µM -0.449095699240924 0.317076429763798 no 2281 0.3266813113938 3220 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3297 9117502 71.43 µM -0.450449114601796 0.31658995915894 no 2282 0.326193318731011 3284 7453720
SGTC_2011 4012611 177 µM -0.451249903907374 0.316302273299904 no 2283 0.325904723050625 3171 2049887
SGTC_678 1218-2179 85.9 µM -0.451592578961758 0.316179200249163 no 2284 0.325781258567446 3261 6820081 YOR116C RPO31
SGTC_2537 larixol 68.93 µM -0.454617462470077 0.31509368632917 no 2285 0.324692234804047 3299 6708759
SGTC_3145 9085516 49.47 µM -0.455452344455822 0.314794359860311 no 2286 0.324391922351094 3271 25236195
SGTC_1496 4469-0713 57.4 µM -0.456692311477017 0.314350024599691 no 2287 0.323946108944183 3309 746691
SGTC_449 xestospongin c 11.1929 µM -0.457111473772554 0.314199880901477 no 2288 0.323795461850074 3301 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1088 bifonazole 369 nM -0.457818606214438 0.313946656142824 no 2289 0.323541383598493 3271 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2238 6671620 73.2395 µM -0.45929659709174 0.313417669252082 no 2290 0.323010595549531 3188 729941
SGTC_2670 beta-carotene 100 µM -0.460535517155412 0.312974543514405 no 2291 0.322565942021904 3280 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2014 4013930 200 µM -0.461064808733665 0.312785313572369 no 2292 0.32237605438165 3329 64556
SGTC_3281 9140613 49.47 µM -0.461807678691911 0.31251980925271 no 2293 0.32210962192859 3252 16013766
SGTC_2445 5742597 35.57 µM -0.464460613321589 0.311572435923675 no 2294 0.321158886014114 3178 1774255
SGTC_1786 berberine 21.6 µM -0.464562378684771 0.311536119891377 no 2295 0.321122439500555 3274 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2555 cholic acid 100 µM -0.464600098750071 0.311522659557967 no 2296 0.321108930775298 3366 6708657 Influences liver metabolism.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.464863233126049 0.311428767565943 no 2297 0.321014700781081 3188 803109
SGTC_2966 9084041 48.03 µM -0.465044600958449 0.311364058770283 no 2298 0.320949758584847 3083 17741380
SGTC_2129 girgensonine 121.053 µM -0.465177172696487 0.311316763234135 no 2299 0.320902292221708 3235 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_252 miconazole 1.30953 nM -0.468120693450727 0.310267452975261 no 2300 0.319849140854496 3288 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_236 1509-0011 5.31 µM -0.468768006306333 0.310036904648925 no 2301 0.31961773546058 3384 3107280
SGTC_1884 5633444 25 µM -0.471797310072981 0.308958974845517 no 2302 0.318535735555351 3345 5724239
SGTC_1873 rapamycin 2 nM -0.472035343290285 0.308874344005381 no 2303 0.318450780769169 3255 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_690 glyoxal 20.3 µM -0.472801160061499 0.30860213272171 no 2304 0.318177523184311 3291 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_831 k061-1017 217 µM -0.473747441766565 0.30826592001873 no 2305 0.317840009023938 3295 1240153
SGTC_2894 9048625 32.47 µM -0.473785042339242 0.308252563901917 no 2306 0.317826600997417 3401 4092861
SGTC_2102 5377816 72.7585 µM -0.474395929040158 0.308035606129405 no 2307 0.317608797760952 3385 1379702
SGTC_973 1325-0077 65.9 µM -0.475059441170187 0.307800034302924 no 2308 0.317372303154832 3257 2835149
SGTC_202 3594-0513 34.79 µM -0.475494768201265 0.307645519813375 no 2309 0.317217180699132 3263 708429
SGTC_1440 4100-1550 40 µM -0.477324816393125 0.30699633796139 no 2310 0.316565421091713 3282 742806
SGTC_2505 galangin 7.89 µM -0.479862113544892 0.306097270739959 no 2311 0.315662721258444 3164 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1259 0671-0132 43 µM -0.480378273945631 0.30591451683077 no 2312 0.315479220035989 3205 X1259
SGTC_109 0132-0036 33.701 µM -0.481019171654516 0.305687665145304 no 2313 0.315251436520086 3268 67274 A color developer.
SGTC_1699 st031318 29.054 µM -0.481774535149608 0.305420392951327 no 2314 0.314983060497323 3334 5340658
SGTC_1938 st074717 56.4 µM -0.483387499193349 0.304850020963169 no 2315 0.314410311282235 3284 17250979
SGTC_626 0214-0009 33 µM -0.483493352498065 0.304812605960028 no 2316 0.314372739309682 3366 3437874
SGTC_1984 st072354 53.1 µM -0.484470063790755 0.304467473062954 no 2317 0.314026152474465 3194 5762938
SGTC_2298 7976326 193.81 µM -0.486923676180728 0.303601227307962 no 2318 0.313156209891508 3271 2235818
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.487530475141825 0.303387167287742 no 2319 0.312941225833014 3260 442882
SGTC_1988 st071872 53.4 µM -0.488669030698261 0.302985701989418 no 2320 0.312538016274348 3367 16414116
SGTC_184 1494-0393 24.714 µM -0.489064418827965 0.302846340086723 no 2321 0.312398045448533 3209 3090647
SGTC_2828 7998861 71.43 µM -0.489357134418396 0.302743185523581 no 2322 0.312294439025264 3328 2988188
SGTC_1136 pergolide 1.05886 µM -0.491103879892805 0.302127950391877 no 2323 0.311676488744915 3214 47811 A dopamine receptor agonist.
SGTC_3299 9121982 43.1275 µM -0.492341488494167 0.301692382443466 no 2324 0.311238977648548 3276 17594604 YPL160W CDC60
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.493118666293633 0.301419004405096 no 2325 0.310964371156337 3310 77254
SGTC_2012 4023501 200 µM -0.493677465396558 0.301222511623614 no 2326 0.310766991186232 3296 3477460
SGTC_2797 7859098 81.82 µM -0.493756708191417 0.301194651831996 no 2327 0.310739005317973 3256 972681
SGTC_3022 9087993 49.47 µM -0.494061694153746 0.301087437201922 no 2328 0.310631304835412 3362 17173644
SGTC_1143 3454-2408 5.08 µM -0.494921136234596 0.300785401879989 no 2329 0.310327895146996 3339 X1143
SGTC_996 3970-0799 1.8 µM -0.500714953121177 0.298752847223511 no 2330 0.308285873528085 3348 6615648 YGL040C HEM2
SGTC_2762 leflunomide 42.06 µM -0.501803662921665 0.298371609940845 no 2331 0.307902818142835 3323 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1117 retinoic acid 1.10837 µM -0.501952195414435 0.298319614973638 no 2332 0.307850574172753 3418 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_829 1635-0120 117 µM -0.502074645990363 0.298276753288791 no 2333 0.307807507036092 3389 285054
SGTC_2588 indole-3-carbinol 100 µM -0.503138982338707 0.297904319109961 no 2334 0.307433280485784 3395 3712 Induces cell cycle arrest.
SGTC_923 1900-2434 73.3 µM -0.503447732551387 0.297796320456629 no 2335 0.307324759677199 3333 5910570
SGTC_2430 5571206 200 µM -0.505261583887561 0.297162208954806 no 2336 0.306687560537654 3420 1731771
SGTC_2276 7947513 42.08 µM -0.506050292688822 0.296886673797616 no 2337 0.306410672102721 3313 2105100
SGTC_220 paclitaxel 373.376 µM -0.507046785571181 0.296538716607011 no 2338 0.30606099585434 3360 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2248 tofa 1.1 µM -0.507414530589579 0.296410353952731 no 2339 0.305931996189582 3217 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1920 st075728 45.7 µM -0.509015784130289 0.295851728071003 no 2340 0.305370580209122 3434 3400306
SGTC_681 1642-0006 26.6 µM -0.509018372731902 0.295850825382734 no 2341 0.305369672988771 3391 4446530
SGTC_2038 4100038 30.985 µM -0.509257161922659 0.295767561077074 no 2342 0.305285990315378 3367 3596803
SGTC_174 3553-0389 74.3 µM -0.509420186599485 0.295710721571278 no 2343 0.305228864843801 3404 738071
SGTC_1519 esterone 74 µM -0.509864452226081 0.295555851249756 no 2344 0.305073213822952 3239 698 A steroid.
SGTC_3050 9093513 49.47 µM -0.51035627170039 0.29538444723681 no 2345 0.304900943154162 3369 25236664
SGTC_2204 7233102 200 µM -0.510462474684291 0.295347440437983 no 2346 0.304863748880793 3282 2172480
SGTC_247 mechlorethamine 29.705 µM -0.513129846914431 0.294418685798493 no 2347 0.303930247281513 3314 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_806 3966-4455 5.86 µM -0.513350795197675 0.294341814129309 no 2348 0.303852979094907 3289 714982
SGTC_2540 epiandrosterone 100 µM -0.513688177986481 0.294224450798202 no 2349 0.303735009314985 3426 441302 A steroid.
SGTC_773 4358-1457 44.6 µM -0.513711853308185 0.294216215817572 no 2350 0.303726731733446 3411 1186886
SGTC_3068 9116768 49.47 µM -0.515646753028273 0.293543560440718 no 2351 0.303050575110844 3384 41904888
SGTC_2560 caryophyllene 100 µM -0.515784963190008 0.293495539834966 no 2352 0.303002302927484 3315 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1553 gossypol 38.6 µM -0.516012936386635 0.293416339348436 no 2353 0.302922687039924 3341 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1268 0828-0275 2.46 µM -0.51663360167372 0.293200763344898 no 2354 0.302705977367556 3389 745337
SGTC_747 3448-8087 38.7 µM -0.517888527041039 0.292765113939693 no 2355 0.30226802362425 3319 5168703
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.518572032927456 0.292527960253853 no 2356 0.30202960801471 3411 5377381
SGTC_2511 berberine 10.47 µM -0.518709201383458 0.292480378144727 no 2357 0.301981772076726 3316 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_219 mitoxanthrone 164.414 µM -0.51921653484711 0.29230442145497 no 2358 0.301804874883191 3367 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1280 0880-0253 10.1 µM -0.521036149571469 0.291673736159455 no 2359 0.301170794503671 3333 6836607
SGTC_1498 4478-3555 97.6 µM -0.52109780302654 0.291652377954616 no 2360 0.301149320666011 3392 3437919
SGTC_2110 5483698 200 µM -0.522105053811034 0.291303545922494 no 2361 0.300798593956828 3330 2848765 YHR062C RPP1
SGTC_471 1-acyl-paf 4 µM -0.52442683194602 0.290500208185161 no 2362 0.299990849058494 3297 16759367
SGTC_2144 5628481 200 µM -0.526030618757063 0.289945902393055 no 2363 0.299433466596282 3339 2818399
SGTC_1609 st001574 46.4 µM -0.528102551841484 0.289230529563493 no 2364 0.298714079889681 3321 3960012
SGTC_331 k048-0133 24.5 µM -0.528364177853996 0.28914025742227 no 2365 0.29862329777678 3345 6813582
SGTC_2089 5281248 129.67 µM -0.528519621615846 0.28908662896452 no 2366 0.298569365989397 3400 2737878
SGTC_2241 6772625 37.8075 µM -0.528563290815672 0.289071563831212 no 2367 0.298554215596349 3401 2285411
SGTC_2096 5468907 200 µM -0.5295284234497 0.288738703740568 no 2368 0.298219466188426 3394 759785
SGTC_1756 st041558 35.5 µM -0.530081202769696 0.288548139580252 no 2369 0.298027815621522 3477 3955792
SGTC_3287 9117173 37.0625 µM -0.530248084184219 0.288490620825686 no 2370 0.297969968270689 3335 2789709
SGTC_909 3448-9333 149 µM -0.530360683947513 0.28845181429556 no 2371 0.297930939865857 3329 3344074
SGTC_504 lovastatin 124 µM -0.532296159352001 0.287785154447414 no 2372 0.297260445921392 3353 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1962 st076595 64.5 µM -0.533825109623633 0.287259034236762 no 2373 0.296731269826536 3360 279619
SGTC_1022 4477-0945 21.3 µM -0.534140162120886 0.287150679523911 no 2374 0.296622282454894 3383 4648966
SGTC_1085 doxorubicin 7.67 µM -0.534175652049574 0.287138474831036 no 2375 0.296610006430926 3430 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1746 st038117 42 µM -0.534407735044337 0.287058669463851 no 2376 0.296529734283683 3387 2898218
SGTC_1214 0358-0031 63.7 µM -0.539131196023239 0.285436720437758 no 2377 0.294898165714321 3481 4301366
SGTC_2636 apigenin dimethyl ether 100 µM -0.54067874488436 0.28490627147413 no 2378 0.294364515664977 3453 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1529 apigenin 74 µM -0.541654424498628 0.284572082386684 no 2379 0.294028295879014 3511 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1814 st052110 31.539 µM -0.544399929618199 0.283632699764273 no 2380 0.293083147113193 3447 674163
SGTC_216 k038-0035 28.382 µM -0.546587435974012 0.28288530294525 no 2381 0.292331101354444 3408 4444231 YPR107C YTH1
SGTC_3105 9121040 49.47 µM -0.547987388193776 0.282407483549997 no 2382 0.29185028132537 3363 41448907
SGTC_3330 9141424 71.43 µM -0.548075731847508 0.282377343896328 no 2383 0.291819951652487 3440 27261020
SGTC_2684 capsaicin 100 µM -0.548876129955925 0.282104347601165 no 2384 0.29154523017806 3457 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1203 3992-3522 103 µM -0.548930468173317 0.282085818766263 no 2385 0.2915265839878 3612 5322312
SGTC_2119 5528445 120.635 µM -0.548956615521909 0.28207690296849 no 2386 0.291517611708434 3457 791935
SGTC_1301 naphtanilide LB 4.81 µM -0.549098313041121 0.282028588903026 no 2387 0.29146899143819 3476 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2593 nobiletin 86.24 µM -0.549285915285598 0.281964629009252 no 2388 0.291404625828638 3365 72344 An anti-infammatory.
SGTC_3338 9144300 39.5675 µM -0.549926229724356 0.281746376990369 no 2389 0.291184986364283 3372 4901274
SGTC_2351 9026858 72.31 µM -0.551184064566345 0.281317879586867 no 2390 0.290753751410355 3356 1409300
SGTC_1195 1502-0147 41.1 µM -0.552248829598506 0.280955399896669 no 2391 0.290388941894982 3436 817940
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.552415925267278 0.280898535744434 no 2392 0.290331711081322 3410 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1409 3909-8004 61.9 µM -0.552744159981818 0.280786850732344 no 2393 0.290219304998064 3404 2119279
SGTC_2278 7948257 134.34 µM -0.553525236029195 0.280521168487946 no 2394 0.289951902510078 3451 1247028
SGTC_2459 5811157 9.22 µM -0.553762227454402 0.280440580154383 no 2395 0.289870791011463 3439 2870684 YBR192W RIM2
SGTC_810 3825-7150 143 µM -0.554866427633931 0.280065247514401 no 2396 0.289493013368207 3494 22330411 YGL099W LSG1
SGTC_2375 9072683 200 µM -0.555035138576426 0.280007921823199 no 2397 0.289435313024447 3506 16798029
SGTC_407 eburnamonine 100 µM -0.556270692869109 0.279588270687738 no 2398 0.28901290940133 3381 3195
SGTC_519 k048-0011 62.8 µM -0.556918592267372 0.279368336311595 no 2399 0.288791525547203 3425 6836379
SGTC_1294 1000-1494 117 µM -0.55708848110732 0.279310680165091 no 2400 0.28873348862855 3398 712797 YDL207W GLE1
SGTC_1167 k781-0610 148 µM -0.557288729382472 0.279242728188182 no 2401 0.28866508746283 3410 4525169
SGTC_2370 9071495 200 µM -0.557330446137818 0.279228573092535 no 2402 0.288650838739193 3407 21791103
SGTC_2346 9031566 143.75 µM -0.558607550184838 0.278795402142724 no 2403 0.288214793041556 3374 4771086
SGTC_801 0866-0028 10.1 µM -0.560272832983649 0.278231059613434 no 2404 0.287646677418026 3452 6849771
SGTC_84 0443-0269 128.823 µM -0.561353462722784 0.277865146589651 no 2405 0.287278301113622 3434 6150058
SGTC_2047 4141938 200 µM -0.562946468774288 0.277326166127409 no 2406 0.286735668116589 3393 3807862
SGTC_341 1486-1430 230 µM -0.563649816966068 0.277088356869253 no 2407 0.286496238112131 3386 2054753 YPL210C SRP72
SGTC_2902 5787006 60.46 µM -0.564317057512945 0.276862848259792 no 2408 0.286269187394934 3380 591003
SGTC_317 4495-0002 170 µM -0.564720163988977 0.27672665313265 no 2409 0.286132058466492 3435 15991618
SGTC_832 4083-0019 164 µM -0.565000248121382 0.276632042145937 no 2410 0.286036797706894 3504 1990758
SGTC_3144 9087057 49.47 µM -0.566735393818014 0.276046272380359 no 2411 0.285446985112411 3435 17249618
SGTC_781 4335-2806 94.4 µM -0.567367870928551 0.275832905293226 no 2412 0.285232136917262 3510 845254
SGTC_1579 chlormadinone acetate 49.4 µM -0.568165242368012 0.275564026390061 no 2413 0.284961385090028 3491 45114258 A steroidal progestin.
SGTC_2191 5911152 200 µM -0.569766047737485 0.275024613711877 no 2414 0.284418193236215 3427 2875902
SGTC_3143 9086658 49.47 µM -0.569833141304303 0.275002017003567 no 2415 0.284395437577652 3460 25236626
SGTC_1926 methyl fluorone black 53.6 µM -0.569948810142024 0.274963062585027 no 2416 0.284356209025011 3363 72721 Reacts with homocysteine.
SGTC_590 k048-0076 22.4 µM -0.570148754047295 0.274895732809589 no 2417 0.284288405070983 3476 6832814
SGTC_276 colchicine 750 µM -0.572015576463918 0.274267485183875 no 2418 0.283655711021432 3520 2833 A microtubule depolymerizer.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.572990079443976 0.27393981451254 no 2419 0.283325705537212 3335 4000243
SGTC_1278 0874-0585 172 µM -0.574696886230092 0.273366377828569 no 2420 0.282748156852588 3458 766306
SGTC_3014 9081533 49.47 µM -0.574943618147754 0.273283532390673 no 2421 0.28266471460912 3494 21367265
SGTC_2898 9056270 58.44 µM -0.575483316847852 0.273102360548929 no 2422 0.282482235223134 3434 19154699
SGTC_1388 3346-4487 254 µM -0.576019245566206 0.272922513178324 no 2423 0.282301086593234 3471 3345614
SGTC_2983 9022671 12.99 µM -0.576737224785747 0.272681665242096 no 2424 0.282058490924227 3509 6405161
SGTC_1565 sinapyl alcohol 95.1 µM -0.576751635891186 0.272676832080518 no 2425 0.282053622630468 3461 5280507 A phenol propionate derived from cinnamic acid.
SGTC_179 1273-0063 6.77 µM -0.578860469059862 0.271970035362231 no 2426 0.281341662794899 3392 3108139
SGTC_1886 st057356 49.9 µM -0.580776140660511 0.271328769503827 no 2427 0.280695668755115 3374 24207747
SGTC_322 k048-0136 19.3 µM -0.581768672541913 0.270996818754794 no 2428 0.280361254078835 3492 6823282
SGTC_408 cantharidin 100 µM -0.581938108005458 0.270940171578468 no 2429 0.280304185316908 3432 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_501 nsc-95397 161 µM -0.582172391749086 0.27086185348052 no 2430 0.28022528381457 3519 262093
SGTC_2033 5192550 145 µM -0.582411634613361 0.270781889272667 no 2431 0.280144723296809 3414 182073
SGTC_283 0987-0079 11.7 µM -0.582644489150814 0.27070407160908 no 2432 0.280066324706245 3509 411556
SGTC_440 fluspirilene 35.1 µM -0.582839196969031 0.270639010772087 no 2433 0.280000777702173 3582 3396 An atypical antipsychotic.
SGTC_2180 6301957 200 µM -0.583259744464923 0.270498513166873 no 2434 0.2798592287593 3483 845462
SGTC_116 0155-0182 31.788 µM -0.583867908408846 0.27029540064565 no 2435 0.279654592803096 3445 771486
SGTC_1115 galangin 695.678 nM -0.586564489662177 0.269395725223155 no 2436 0.278748118833063 3553 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2999 9069765 71.4286 µM -0.586632943899041 0.26937290600937 no 2437 0.278725126107491 3436 2097066
SGTC_1121 fusaric acid 630.51 nM -0.587979215444684 0.268924323551564 no 2438 0.278273121924475 3417 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3337 9144342 33.5465 µM -0.588297310455843 0.268818387969235 no 2439 0.278166375274329 3476 17682949
SGTC_2552 juarezic acid 87.02 µM -0.588699818981028 0.268684370093948 no 2440 0.27803132967972 3547 1549512
SGTC_2340 7987427 183.45 µM -0.589805072186701 0.268316541463736 no 2441 0.277660670886589 3476 2239331
SGTC_2379 9035213 200 µM -0.591177779098381 0.26786005707238 no 2442 0.277200654886756 3514 646551
SGTC_647 0140-0236 81 µM -0.593491564905897 0.267091509683142 no 2443 0.276426113202012 3506 990837
SGTC_2784 7567673 72.73 µM -0.595437239559712 0.266446097005959 no 2444 0.275775619599185 3542 3471247
SGTC_1165 k072-0275 30.3 µM -0.596099652637041 0.266226543727104 no 2445 0.275554328111883 3560 6153523 YGL055W OLE1
SGTC_358 0075-0058 9.45 µM -0.596350192638096 0.266143527456973 no 2446 0.275470653301703 3570 1069125
SGTC_517 1365-0151 113 µM -0.59756203347772 0.265742169881196 no 2447 0.275066101834696 3552 768657
SGTC_2933 9026794 32.47 µM -0.598225426420531 0.265522586425781 no 2448 0.274844763935962 3451 17586027
SGTC_1826 st055655 41.6 µM -0.598692554977925 0.265368021842218 no 2449 0.274688961404343 3492 676168
SGTC_875 0709-0210 25.7 µM -0.598731693107105 0.265355073800574 no 2450 0.274675909545996 3533 6251364
SGTC_72 0744-0168 198.391 µM -0.59884811057183 0.265316561382499 no 2451 0.274637088234632 3425 677577
SGTC_2256 7954252 200 µM -0.599517617900591 0.265095134703464 no 2452 0.274413882591259 3464 2972920
SGTC_1643 st009866 20.2 µM -0.600560999184197 0.264750243630481 no 2453 0.274066210487713 3516 3156273 YOR207C RET1
SGTC_569 4130-2812 160 µM -0.601521827340972 0.26443284251805 no 2454 0.273746239084166 3456 743552
SGTC_2352 9027995 87.8 µM -0.604117973041289 0.263576198359424 no 2455 0.272882605511478 3468 2997347
SGTC_2010 4012422 159 µM -0.605057672639072 0.26326647727602 no 2456 0.272570338548334 3474 952393
SGTC_427 1354-0053 47.3 µM -0.605458182541333 0.263134527393494 no 2457 0.27243730100434 3596 6813657
SGTC_3265 9137266 49.47 µM -0.605795104163456 0.263023553145231 no 2458 0.272325410586944 3482 17224265
SGTC_2875 9039966 71.43 µM -0.606088248149038 0.262927017709709 no 2459 0.272228077136795 3504 6463691
SGTC_1224 0823-0416 294 µM -0.606786515580227 0.262697143794308 no 2460 0.271996299030985 3551 3598164
SGTC_3008 9078912 71.4286 µM -0.608665051612842 0.262079229021505 no 2461 0.271373238230899 3521 16648731
SGTC_256 clotrimazole 625 nM -0.608976254796295 0.261976935621445 no 2462 0.271270089060974 3517 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1323 1348-1351 11.2 µM -0.610178838196843 0.26158183540628 no 2463 0.270871673177979 3455 6989654
SGTC_889 0919-1524 82.7 µM -0.610648924433352 0.26142747510789 no 2464 0.270716013033831 3505 3905452
SGTC_1100 amiodarone 5.07 µM -0.61154513936818 0.261133318320764 no 2465 0.270419372250974 3560 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_284 0988-0104 32.6 µM -0.611743719249183 0.261068163214161 no 2466 0.270353665711613 3537 4666532
SGTC_2417 cerulenin 830 nM -0.612858661543344 0.260702500011453 no 2467 0.269984899456267 3600 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3127 9126946 49.47 µM -0.614875457591657 0.260041729641978 no 2468 0.26931848592594 3457 27243249
SGTC_1843 st055809 45.5 µM -0.615463589709212 0.259849200494414 no 2469 0.269124303841434 3548 16413835
SGTC_650 1328-0195 38 µM -0.617404604494716 0.25921431803262 no 2470 0.268483942846423 3538 2780821
SGTC_2918 7977171 22.06 µM -0.618685876767194 0.258795669102103 no 2471 0.268061657910026 3503 2236483
SGTC_1063 disulfiram 1.84 µM -0.619809278139091 0.25842889175548 no 2472 0.267691679758272 3545 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.61996701169678 0.258377415170544 no 2473 0.267639752800345 3538 688788
SGTC_3261 9137475 49.47 µM -0.619972753507154 0.258375541422272 no 2474 0.267637862653171 3437 17027690
SGTC_979 1426-2828 121 µM -0.620367629657383 0.258246696780049 no 2475 0.267507889475762 3586 747872
SGTC_2331 7980721 200 µM -0.621221308057737 0.257968262834416 no 2476 0.267227010719363 3520 2981221
SGTC_2713 st079149 53.4 µM -0.622053497703361 0.257696987589119 no 2477 0.26695334557092 3540 3103253
SGTC_3309 9129340 25.759 µM -0.623228943344627 0.257314071032732 no 2478 0.266567042194272 3548 17158987
SGTC_615 k087-0205 167 µM -0.623705629375946 0.257158868740185 no 2479 0.266410462706311 3512 9642773
SGTC_1997 st073024 93.8 µM -0.623807583568154 0.257125680203535 no 2480 0.266376979335199 3556 686268
SGTC_128 0906-2981 13.371 µM -0.62464447210205 0.256853337102382 no 2481 0.266102212388907 3546 6740226
SGTC_1235 benzylparaben 21.5 µM -0.625845046325737 0.256462904487177 no 2482 0.265708291079586 3533 7180
SGTC_3162 9099653 49.47 µM -0.626211257901881 0.256343872263239 no 2483 0.265588191997872 3544 25237511
SGTC_3311 9131146 2.8755 µM -0.626777569984731 0.256159856726516 no 2484 0.265402524181657 3515 4900406 YPR165W RHO1
SGTC_1760 st045453 10.4495 µM -0.626891627788033 0.25612280350432 no 2485 0.265365137818155 3571 3323419 YIL048W NEO1
SGTC_1390 3413-2614 145 µM -0.627216418494003 0.256017306159076 no 2486 0.265258691150832 3563 3421432
SGTC_687 k029-0044 34.9 µM -0.627279056497048 0.255996962916759 no 2487 0.265238164711556 3576 5829338
SGTC_2532 xanthone 78.9 µM -0.627636537922717 0.255880878115524 no 2488 0.26512103368134 3477 7020 An insecticide.
SGTC_204 PMA1.184 62.41 µM -0.628662052638994 0.255548015636609 no 2489 0.264785163204705 3576 2252213 YGL008C PMA1
SGTC_210 3551-0445 56.827 µM -0.630893157811779 0.254824623651058 no 2490 0.264055192968863 3611 2865180 YOR207C RET1
SGTC_570 0987-0065 62.6 µM -0.632273438954508 0.254377631918874 no 2491 0.263604108248587 3461 3104428
SGTC_3106 9121286 49.47 µM -0.634400083558731 0.253689742242687 no 2492 0.262909877538333 3618 15943471
SGTC_1347 1493-0251 600 nM -0.634946205287411 0.253513250144604 no 2493 0.262731750257352 3581 3986378
SGTC_3211 9128781 49.47 µM -0.635537882341881 0.253322108605279 no 2494 0.262538833998861 3514 17194361
SGTC_2748 diazoxide 86.69 µM -0.63686034124458 0.252895161722041 no 2495 0.262107908656172 3516 3019 A potassium channel activatior.
SGTC_2075 5212009 200 µM -0.637492723042506 0.252691135485372 no 2496 0.261901974227082 3524 780898
SGTC_3064 1327-0027 10 µM -0.638794528783206 0.25227140510637 no 2497 0.261478303997484 3481 16000455 YPR107C YTH1
SGTC_323 4013-0906 34.3 µM -0.640709691128198 0.251654584110866 no 2498 0.260855658290188 3586 2910086
SGTC_2419 paclitaxel 166.5 µM -0.641918329698783 0.251265725327156 no 2499 0.260463106115376 3531 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1957 st077035 62.4 µM -0.64292394777051 0.250942427222523 no 2500 0.260136724723753 3645 705593
SGTC_384 k007-0144 5.16 µM -0.643013583414184 0.250913620775513 no 2501 0.260107642994985 3592 6824886
SGTC_183 3914-0051 30.55 µM -0.644530377614177 0.250426430068704 no 2502 0.259615782791497 3579 1596232
SGTC_1107 amlodipine 47 µM -0.644686299405294 0.250376376792014 no 2503 0.259565248302496 3509 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1405 3909-7894 12 µM -0.645264004652701 0.250190970815902 no 2504 0.25937805743627 3591 7104060
SGTC_1741 st038134 10.228 µM -0.64544399785245 0.250133219534864 no 2505 0.259319749416542 3658 1272587
SGTC_1949 st076024 69.1 µM -0.645759979133646 0.250031853233255 no 2506 0.259217405028894 3567 2921930
SGTC_2771 fluoxetine 41.05 µM -0.645860286720261 0.249999679274407 no 2507 0.259184920386563 3602 3386 A selective serotonin reuptake inhibitor.
SGTC_251 melphalan 456.522 µM -0.646873007670575 0.249674969091154 no 2508 0.258857068310738 3639 460612 A DNA alkylator.
SGTC_2706 st078239 82.5 µM -0.647880652818788 0.249352108819064 no 2509 0.258531072538333 3610 15434492
SGTC_432 NS 1619 61.3 µM -0.648517042480873 0.249148317175132 no 2510 0.258325295830996 3596 4552 A K+/calcium channel activator.
SGTC_867 0518-0118 155 µM -0.649551811551166 0.248817141354323 no 2511 0.257990884368788 3626 6848158
SGTC_2157 5649910 96.377 µM -0.650228761837352 0.248600611613516 no 2512 0.257772232548905 3567 2858091
SGTC_330 1488-0319 80.1 µM -0.65115445979611 0.248304679844312 no 2513 0.257473392145501 3574 6846614
SGTC_1129 3453-1384 223 µM -0.654493666169209 0.247238748101368 no 2514 0.256396903233735 3651 1084452
SGTC_1321 1326-2144 215 µM -0.655514862597821 0.246913253978143 no 2515 0.256068160218471 3573 3513030
SGTC_2314 7727897 200 µM -0.65665735781782 0.246549369309577 no 2516 0.255700629507376 3584 900724
SGTC_3323 9138564 53.9225 µM -0.656883447575948 0.246477393799825 no 2517 0.255627931071834 3622 43912313 YNL103W MET4
SGTC_3194 9111903 49.47 µM -0.657338312306243 0.246332622062252 no 2518 0.25548170349021 3634 17087251
SGTC_49 0717-0965 32.132 µM -0.657842623861149 0.246172165971132 no 2519 0.255319631099686 3697 5889349 YGL099W LSG1
SGTC_1134 3477-0009 42.5 µM -0.658544708843607 0.245948877954019 no 2520 0.255094089085274 3664 3973534
SGTC_3016 9080866 49.47 µM -0.659334984704431 0.245697672168739 no 2521 0.25484034082693 3607 17066299
SGTC_333 3486-0131 40.1 µM -0.659554366455175 0.245627961509801 no 2522 0.254769923370579 3678 6744690
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.659835841148825 0.245538535781917 no 2523 0.254679590158017 3569 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_353 1988-1175 58.3 µM -0.660666274760207 0.245274805380456 no 2524 0.254413178231054 3494 2788357
SGTC_712 r015-0009 80.6 µM -0.660870690309941 0.245209910135445 no 2525 0.254347621958123 3586 6813872 YLR060W FRS1
SGTC_2465 5809242 33.21 µM -0.663277030278974 0.244446670457533 no 2526 0.253576572422447 3621 2731748
SGTC_1113 artemisinin 1.17947 µM -0.663561071628535 0.244356663142562 no 2527 0.253485639795332 3620 2240 An anti-malaria and mitochondrial poison.
SGTC_2877 9040724 71.43 µM -0.665021421710866 0.243894188015852 no 2528 0.253018395865342 3619 6463895
SGTC_1310 1188-0297 994 nM -0.666770020047817 0.243341050113416 no 2529 0.252459522652922 3579 1588352
SGTC_1793 st048256 72.231 µM -0.666809357867731 0.243328614097727 no 2530 0.252446957295493 3559 672022
SGTC_520 3584-0023 682 µM -0.669568061377141 0.242457351833633 no 2531 0.251566589895075 3589 1340790
SGTC_514 4466-0038 2.65 nM -0.670095383448263 0.242291003945446 no 2532 0.251398493819435 3588 5722064
SGTC_568 1193-0097 7.48 µM -0.671061788922693 0.241986304366149 no 2533 0.251090583947309 3548 3646150
SGTC_2678 equilin 100 µM -0.673108954363093 0.241341537213106 no 2534 0.250438988818496 3655 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2357 9067248 200 µM -0.673573244254193 0.241195436263267 no 2535 0.250291334114568 3623 9150235
SGTC_2124 5246320 200 µM -0.673694653022623 0.241157239751533 no 2536 0.250252730989957 3635 579342
SGTC_1239 0337-0584 35.4 µM -0.674490759476595 0.240906857541956 no 2537 0.249999679274407 3684 914301 YML130C ERO1
SGTC_3169 9102970 49.47 µM -0.675517319892171 0.24058420445882 no 2538 0.249673575614265 3690 17027839
SGTC_325 2810-4341 181 µM -0.675785865589653 0.240499838040014 no 2539 0.249588304989237 3636 774970
SGTC_2438 5259590 200 µM -0.676136227200658 0.240389792527744 no 2540 0.249477078830864 3643 1201127
SGTC_1210 3013-0140 750 nM -0.677331324798949 0.240014629273863 no 2541 0.249097880159727 3663 905973
SGTC_2488 5268135 45.7 µM -0.677595789541808 0.239931652057656 no 2542 0.249014008231226 3639 1270356 YLR208W SEC13
SGTC_622 1348-1566 26.3 µM -0.678053370547879 0.239788120549372 no 2543 0.24886892721588 3664 7340407
SGTC_508 roscovitine 141 µM -0.67870812505975 0.239582822233687 no 2544 0.248661408483525 3673 160355 A CDKinase inhibitor.
SGTC_552 k242-0005 476 µM -0.679379255509408 0.239372488860167 no 2545 0.248448795226862 3659 4088318
SGTC_133 0724-0033 378.92 µM -0.67956137057894 0.239315431103552 no 2546 0.248391118124783 3549 280309
SGTC_237 nikkomycin 200 µM -0.682489787993471 0.238398961181587 no 2547 0.247464648945051 3689 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3165 9101544 49.47 µM -0.683739081614763 0.238008571110535 no 2548 0.247069970119537 3637 5002184
SGTC_2900 5328528 85.29 µM -0.684154720264834 0.237878766482627 no 2549 0.246938735588671 3670 795359
SGTC_1393 3470-5649 58.2 µM -0.684370074921235 0.237811526142749 no 2550 0.246870753777601 3585 4108395
SGTC_1468 k284-1086 134 µM -0.685052488296845 0.237598524589092 no 2551 0.246655399971853 3671 15996457
SGTC_1641 st009299 47.1 µM -0.686095756437899 0.23727309197455 no 2552 0.246326363364728 3607 4046054
SGTC_1811 st050069 61.5 µM -0.686131059250584 0.237262084049541 no 2553 0.246315233318678 3634 3877702
SGTC_2523 spermine 47.74 µM -0.689231993981641 0.236296263171337 no 2554 0.245338643051299 3629 1103 A DNA binding polyamine.
SGTC_1575 cyproterone acetate 48 µM -0.6894511505741 0.236228086396658 no 2555 0.245269701981936 3620 9880 An androgen receptor antagonist and liver toxin.
SGTC_972 1319-0219 195 µM -0.689852840185277 0.236103154095924 no 2556 0.245143367727834 3624 23903702
SGTC_963 1269-2853 151 µM -0.690363315437978 0.235944440145514 no 2557 0.244982870119451 3650 3668223
SGTC_2142 5622915 118.518 µM -0.690490783596562 0.235904817675247 no 2558 0.244942801907204 3651 5322196
SGTC_1087 pterostilbene 9.05 µM -0.690971174545644 0.235755524904899 no 2559 0.244791827992937 3682 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2337 9009472 200 µM -0.69112942937854 0.235706354909139 no 2560 0.244742103739713 3680 5742383
SGTC_1545 lovastatin 49.4 µM -0.691850936636125 0.235482253289547 no 2561 0.244515472419736 3710 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_631 k072-0230 41.5 µM -0.69206871395265 0.235414634319369 no 2562 0.244447089004853 3677 5773147
SGTC_2683 piperine 63.03 µM -0.692412338437214 0.235307962113511 no 2563 0.244339209766549 3636 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1943 st076331 65.2 µM -0.694697961948801 0.234599109766133 no 2564 0.243622302771372 3721 24208415
SGTC_581 0958-0271 211 µM -0.695294087233366 0.234414424692437 no 2565 0.243435509486669 3675 4591145
SGTC_2006 4011487 200 µM -0.699730466516359 0.233042523943449 no 2566 0.242047823052645 3712 45595294
SGTC_1086 cerivastatin 2.18 µM -0.702008879087182 0.232339686893252 no 2567 0.241336813086908 3632 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2989 9073649 71.4286 µM -0.70235679343592 0.232232467321097 no 2568 0.241228341591684 3660 21367202
SGTC_1829 berberine 14.4 µM -0.704523467373573 0.23156536594589 no 2569 0.240553420432731 3694 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1800 st050079 29.0735 µM -0.70552549751926 0.231257210571681 no 2570 0.240241635057238 3639 3645560
SGTC_852 0418-0143 439 µM -0.706240526939162 0.231037456766541 no 2571 0.240019285721121 3706 5369229
SGTC_3170 9103054 49.47 µM -0.70704925713768 0.230789045933036 no 2572 0.239767933981082 3656 16432970
SGTC_3133 9127736 49.47 µM -0.707592303020461 0.230622326859534 no 2573 0.239599237027241 3684 27243420
SGTC_559 1550-0661 158 µM -0.708897278277155 0.230221965164858 no 2574 0.239194112113363 3721 5830875
SGTC_2474 5321570 43.32 µM -0.709656573788063 0.229989195062861 no 2575 0.238958563900034 3720 2841384
SGTC_714 4296-0578 26.1 µM -0.710161849092871 0.229834370569119 no 2576 0.238801887997594 3712 1589775
SGTC_1695 st026914 34.495 µM -0.710284403675234 0.229796826665851 no 2577 0.2387638947092 3659 3289191
SGTC_1118 chelidonine 707.474 nM -0.711394543382414 0.229456898125944 no 2578 0.238419889702531 3695 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2301 7769476 200 µM -0.712650560800586 0.22907264134647 no 2579 0.238031008232869 3714 977820
SGTC_927 2425-1185 123 µM -0.712651603790404 0.229072322411868 no 2580 0.238030685452417 3677 730375
SGTC_264 promethazine 12.5 mM -0.713523571084519 0.228805771752251 no 2581 0.23776091635078 3728 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3289 9119912 71.43 µM -0.714100129556102 0.228629619933255 no 2582 0.237582632929057 3698 17014829
SGTC_1123 mangostin 811.285 nM -0.714116748100534 0.228624543716787 no 2583 0.237577495230427 3690 5281650 An antioxidant.
SGTC_524 r073-0010 27.8 µM -0.715948191537645 0.228065508273897 no 2584 0.237011669926408 3645 2772106
SGTC_2184 6075246 200 µM -0.716222382941934 0.227981879457164 no 2585 0.236927022152192 3744 2267320
SGTC_3024 9090631 49.47 µM -0.717091623076962 0.227716873881663 no 2586 0.23665878211428 3644 25236383
SGTC_1591 genipin 88.4 µM -0.718101107237884 0.227409329784732 no 2587 0.236347473757408 3702 442424 A DNA cross-linking agent.
SGTC_1968 st069590 43.6 µM -0.71859416380983 0.227259202872017 no 2588 0.23619550518834 3675 6384066
SGTC_1986 st071812 45 µM -0.718698118576848 0.227227557634234 no 2589 0.23616347140099 3669 11838594
SGTC_2197 6588183 93.1375 µM -0.719096892040202 0.22710618863372 no 2590 0.236040611075297 3669 884136
SGTC_186 3455-3465 67.277 µM -0.71987390015599 0.226869806751608 no 2591 0.235801319537396 3661 755278
SGTC_1621 st003705 32.4 µM -0.720757865251384 0.226601055188855 no 2592 0.235529251671348 3729 24207032
SGTC_1359 1582-0056 520 nM -0.721289464800252 0.22643951975632 no 2593 0.23536571874138 3766 3661189
SGTC_1945 st075991 56.6 µM -0.722390568687709 0.226105137807469 no 2594 0.235027191885419 3644 1084980
SGTC_2806 7952793 58.44 µM -0.722738505188619 0.225999534907504 no 2595 0.23492027714441 3727 2972490
SGTC_1798 st045719 60.953 µM -0.723599525560394 0.225738324811326 no 2596 0.234655816379252 3646 3980186
SGTC_1765 st044815 90.4 µM -0.725499221600628 0.225162613354195 no 2597 0.2340729111177 3731 645695
SGTC_916 4466-0038 42 nM -0.726382620586593 0.224895178891353 no 2598 0.233802121204486 3781 5722064 YGL116W CDC20
SGTC_2452 5863136 48.41 µM -0.727064431972295 0.224688894923122 no 2599 0.233593243073854 3692 2184096
SGTC_2283 7944793 200 µM -0.72753022368694 0.224548030040951 no 2600 0.233450603736077 3728 2970533
SGTC_3232 9132874 49.47 µM -0.729915894198799 0.223827340792614 no 2601 0.232720798128182 3716 3784940
SGTC_1969 st069479 40.1 µM -0.730722414283512 0.22358399613045 no 2602 0.232474360921494 3687 3895485
SGTC_659 k018-0002 107 µM -0.730904319255742 0.223529132243723 no 2603 0.232418798794625 3699 6797879 YHR007C ERG11
SGTC_3201 9113999 49.47 µM -0.731764937872925 0.223269667136445 no 2604 0.232156026531878 3742 16649224
SGTC_3217 9129673 49.47 µM -0.732792723590458 0.222960028081503 no 2605 0.231842429983577 3716 17248312
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.733724558373135 0.22267950751554 no 2606 0.231558313911277 3698 61125 An anti-inflammatory.
SGTC_2851 9015922 71.43 µM -0.733966129775216 0.222606817445586 no 2607 0.231484690573756 3723 2996893
SGTC_1813 st051246 8.6015 µM -0.735374503714538 0.222183299951116 no 2608 0.231055722594821 3670 5291959
SGTC_1205 4161-2785 76 µM -0.735462799958732 0.222156763377996 no 2609 0.231028843771431 3786 3498106
SGTC_1055 3448-0672 86 µM -0.736062603392673 0.221976546205484 no 2610 0.230846299984109 3725 748378
SGTC_2252 omeprazole 400 µM -0.736068698803296 0.221974715204603 no 2611 0.230844445324322 3669 4594 A proton pump inhibitor.
SGTC_2003 4023581 200 µM -0.737418021075619 0.221569604481221 no 2612 0.230434089861007 3773 16641307
SGTC_2135 5326629 150.42 µM -0.739658090061025 0.220897996390317 no 2613 0.229753742098137 3720 5020077
SGTC_1026 k007-1105 30.6 µM -0.739728130245338 0.220877016042574 no 2614 0.229732487831523 3736 7066794
SGTC_1982 st072467 71.9 µM -0.741856398267989 0.220240043354111 no 2615 0.22908717282146 3736 3163533
SGTC_352 k048-0007 5.11 µM -0.742261745201841 0.22011884595286 no 2616 0.228964382406579 3756 6811911
SGTC_2034 5197015 53.07 µM -0.742413547244962 0.220073467488423 no 2617 0.228918407019029 3728 780676
SGTC_2641 levomentholum 100 µM -0.744415429529781 0.219475543354418 no 2618 0.228312593629436 3718 16666
SGTC_897 1000-0139 31.4 µM -0.74460068005458 0.219420259764971 no 2619 0.228256578353314 3711 6151020
SGTC_3121 9125696 49.47 µM -0.745263820579577 0.219222426927691 no 2620 0.22805612404124 3806 1235365
SGTC_787 4152-0075 138 µM -0.74565768755727 0.219104974256709 no 2621 0.227937112695822 3771 9566539
SGTC_2650 prasterone 100 µM -0.746888681297602 0.218738120467064 no 2622 0.22756537940125 3705 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2491 paeonol 100 µM -0.748683691580875 0.218203815718894 no 2623 0.227023937728159 3653 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2393 9031399 185.94 µM -0.748831133754775 0.218159961368685 no 2624 0.226979496007068 3777 1526623 YDL150W RPC53
SGTC_2790 5423970 71.43 µM -0.749974387016964 0.217820091144131 no 2625 0.226635065478892 3796 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1556 plumbagin 1.48 µM -0.750919298520704 0.217539415297161 no 2626 0.226350612633322 3678 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_76 0433-0009 400.328 µM -0.750958223433992 0.217527857546837 no 2627 0.226338899140085 3833 2841569
SGTC_1624 st003710 6.25 µM -0.752099050215689 0.217189275871953 no 2628 0.225995747543239 3753 24207033
SGTC_611 3453-1652 23.7 µM -0.752971358560594 0.216930592278054 no 2629 0.225733562689376 3732 1560575
SGTC_1603 st002045 67.8 µM -0.753375675828313 0.216810752164539 no 2630 0.225612097686849 3750 5887985
SGTC_1317 1273-0028 910 nM -0.753856002771814 0.2166684324552 no 2631 0.225467845934928 3749 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_594 1487-1584 10.8 µM -0.754031053782206 0.216616578702593 no 2632 0.225415287612114 3744 5013332
SGTC_620 0109-0052 432 µM -0.754106990964413 0.216594086761415 no 2633 0.225392489952777 3732 493037
SGTC_2635 hydroquinidine 100 µM -0.755117984981268 0.216294767769745 no 2634 0.2250890964215 3727 442912 An experimental heart treatment.
SGTC_2262 9014885 67.46 µM -0.756964651349033 0.215748654839194 no 2635 0.224535520174058 3692 6457424
SGTC_2456 5770359 74.46 µM -0.757242820337562 0.215666461504996 no 2636 0.224452200289287 3746 3118787
SGTC_1785 bathophenanthroline 24 µM -0.758251231615922 0.215368648523025 no 2637 0.224150298262319 3712 72812 An iron chelator.
SGTC_2595 hexamethylquercetagetin 100 µM -0.760579294535512 0.214682016297489 no 2638 0.22345419540278 3739 386331
SGTC_1349 flufenamic acid 69 µM -0.761797262889337 0.214323299664649 no 2639 0.223090507129431 3736 3371 A non-steroidal anti-inflammatory.
SGTC_1679 SEC14.276 6.7 µM -0.762786557078737 0.214032189018748 no 2640 0.222795349745017 3819 1005053 YMR079W SEC14
SGTC_608 k048-0125 159 µM -0.762829509307275 0.214019555070491 no 2641 0.222782539926444 3781 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_939 1165-0479 45.3 µM -0.763470928183019 0.21383094007254 no 2642 0.222591296892685 3717 1377347
SGTC_2944 9067346 25.62 µM -0.764301748489676 0.213586773826543 no 2643 0.222343721829935 3706 6473075
SGTC_931 2812-0076 566 µM -0.76693566078346 0.212813779209463 no 2644 0.22155988495521 3800 3450959
SGTC_2258 7960471 200 µM -0.76828102967858 0.212419574308412 no 2645 0.22116012123389 3779 2974708
SGTC_1373 2887-0003 58.5 µM -0.768913894401769 0.212234287033264 no 2646 0.220972214240858 3788 776948
SGTC_597 k018-0003 82.8 µM -0.769583163141764 0.212038444371862 no 2647 0.220773597807707 3872 6786234
SGTC_2421 5690543 90.72 µM -0.770195566677978 0.211859334341978 no 2648 0.220591946659169 3819 3397993
SGTC_2117 5521686 200 µM -0.770370669739309 0.211808138121756 no 2649 0.220540023332276 3757 803312
SGTC_2462 5162487 171.77 µM -0.770675956823393 0.211718896318302 no 2650 0.220449513275398 3711 2259986
SGTC_422 cantharidin 155 µM -0.771232856959066 0.211556159450255 no 2651 0.220284461032564 3734 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2015 5119600 184 µM -0.773246831332562 0.210968249268994 no 2652 0.219688157655696 3800 2828786
SGTC_1790 st045711 43.5 µM -0.775831077047826 0.210215272900268 no 2653 0.218924366029707 3775 585119
SGTC_587 k089-0003 57 µM -0.776612806661095 0.209987810243336 no 2654 0.218693621740824 3708 9659696
SGTC_778 3456-2434 196 µM -0.776814042643677 0.209929279306862 no 2655 0.218634245280546 3833 5539063
SGTC_3132 9126706 49.47 µM -0.777504402399373 0.209728556075781 no 2656 0.218430619056711 3811 850858
SGTC_1035 k081-0041 55.2 µM -0.778965403258871 0.209304139973586 no 2657 0.218000047447453 3781 731709
SGTC_990 3985-0011 41.3 µM -0.779706107082956 0.209089161113304 no 2658 0.217781941662759 3812 5399565 YGL099W LSG1
SGTC_2927 9011802 47.9 µM -0.781886221209189 0.208457168693459 no 2659 0.217140721689275 3815 43912568
SGTC_326 k292-0812 17.5 µM -0.782314901043051 0.208333031531236 no 2660 0.217014765876617 3753 3579357
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.785026576418781 0.207548795162404 no 2661 0.216218993347245 3817 689007
SGTC_2831 7999036 19.48 µM -0.785130192145016 0.20751886338204 no 2662 0.216188619664089 3870 2988270
SGTC_701 4424-0219 185 µM -0.785581569835389 0.20738850234441 no 2663 0.216056332641753 3813 2911779
SGTC_1345 1488-0192 31.4 µM -0.786231437411508 0.207200901089931 no 2664 0.215865955786402 3809 658348
SGTC_2581 avocatin a 64 µM -0.786759646346931 0.207048493750058 no 2665 0.215711290125597 3823 6710728 A skin care supplement.
SGTC_910 3454-3003 490 µM -0.787092462788299 0.206952498266994 no 2666 0.215613870638039 3728 820824
SGTC_1796 st049173 110.4 µM -0.791662078069036 0.205637132632156 no 2667 0.214278869800708 3763 94134
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.792865502391927 0.205291553751346 no 2668 0.213928094144833 3820 1273210
SGTC_2224 6650123 117.647 µM -0.795664002635332 0.204489263314051 no 2669 0.213113677549386 3781 2908370
SGTC_3336 9143619 71.43 µM -0.79701736818668 0.204101942899476 no 2670 0.212720472210857 3832 45595730
SGTC_1720 st037298 9.481 µM -0.798193545037013 0.203765687399945 no 2671 0.212379091361718 3849 597396
SGTC_2917 7979103 53.79 µM -0.799745247555927 0.203322579002919 no 2672 0.211929205734457 3893 2980565
SGTC_442 cape 100 µM -0.801471933385725 0.202830178424229 no 2673 0.211429243027533 3774 5281787
SGTC_2943 9068529 45.32 µM -0.802520276342995 0.202531569375668 no 2674 0.211126032117828 3849 3270634
SGTC_462 ag-879 158 µM -0.803914390357078 0.202134878595461 no 2675 0.210723209313848 3862 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_948 3448-0295 75.3 µM -0.804421631250925 0.20199066021404 no 2676 0.210576756337738 3840 678569
SGTC_804 1595-0054 20.9 µM -0.806071787767581 0.201521915112358 no 2677 0.2101007287946 3797 761523 Stimulates phospholipase C.
SGTC_3153 9100258 49.47 µM -0.806140749985202 0.201502339835169 no 2678 0.210080848747066 3775 25236848
SGTC_3237 9133362 49.47 µM -0.80693675781335 0.201276471441226 no 2679 0.209851460012106 3776 43845137
SGTC_653 0203-0016 55.2 µM -0.808934246946474 0.200710349691259 no 2680 0.20927648432394 3879 295302
SGTC_1350 1495-0454 146 µM -0.809678753919556 0.200499588752275 no 2681 0.209062416013615 3850 1069057
SGTC_359 0081-0058 15.9 µM -0.810110366826288 0.200377465232848 no 2682 0.208938373296148 3844 3494159
SGTC_1834 st055981 52.8 µM -0.810331696501906 0.200314858030926 no 2683 0.208874781419224 3909 471719 YDL150W RPC53
SGTC_2592 piperlongumine 83.33 µM -0.813575589601125 0.199398611803302 no 2684 0.207944063337144 3881 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3271 9137798 49.47 µM -0.818945442704151 0.197887439441842 no 2685 0.206408770703382 3765 6498326
SGTC_105 0111-0055 734.78 µM -0.819086479402526 0.197847842669729 no 2686 0.20636853768453 3874 5179370
SGTC_3344 9148862 3.898 µM -0.820233614529297 0.197525956470822 no 2687 0.20604147132928 3884 4905352
SGTC_1400 3771-8998 51.5 µM -0.821579404545303 0.197148731568105 no 2688 0.205658157448512 3778 670767
SGTC_2794 7785382 27.27 µM -0.821919134267323 0.197053574290761 no 2689 0.205561461074874 3796 2205081
SGTC_3331 9141060 1.957 µM -0.823071697902456 0.196730951847845 no 2690 0.205233611109084 3848 4906567 YPR165W RHO1
SGTC_228 caffeine 993.056 µM -0.82415594477191 0.19642774466131 no 2691 0.204925477808605 3846 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1492 4158-0558 28.5 µM -0.825543395105041 0.196040160669167 no 2692 0.204531578229597 3867 3967268
SGTC_2398 5228213 48.84 µM -0.825569287356553 0.196032932085631 no 2693 0.204524231659248 3865 80771 YMR134W ERG29
SGTC_2910 7948405 25.97 µM -0.825636349994953 0.196014210329427 no 2694 0.204505204287824 3754 2971328
SGTC_2057 5236571 38.335 µM -0.830121536493439 0.19476455213512 no 2695 0.203235035864953 3857 54684039 YBR257W POP4
SGTC_1922 5578187 25 µM -0.831545166904801 0.194368917121223 no 2696 0.202832861826182 3852 1350412
SGTC_2763 lisinopril 49.32 µM -0.832654388275271 0.194060997570915 no 2697 0.202519837780389 3795 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2084 5306078 60.6385 µM -0.83391897271003 0.193710312051976 no 2698 0.202163322558316 3831 679340
SGTC_3293 9120939 62.045 µM -0.834154385310301 0.193645071797117 no 2699 0.202096995854036 3863 934087
SGTC_1397 3532-0190 20.1 µM -0.838331405654995 0.19248971691556 no 2700 0.200922301118589 3800 5322280
SGTC_817 1391-0715 46 µM -0.838344468248836 0.192486110452801 no 2701 0.200918633990084 3902 1353946
SGTC_206 4546-0025 72.014 µM -0.839086560228076 0.192281293480095 no 2702 0.20071036867924 3933 6620745 YIL048W NEO1
SGTC_3104 9120930 49.47 µM -0.839233155650285 0.192240848997592 no 2703 0.200669242561184 3917 17014836
SGTC_78 0336-0123 156.75 µM -0.840633883047813 0.191854662176855 no 2704 0.200276535385308 3743 6765896
SGTC_2307 7538926 6.34 µM -0.842730151885988 0.191277599457712 no 2705 0.199689689990124 3916 96582
SGTC_3096 9117468 49.47 µM -0.843948476845247 0.190942707282126 no 2706 0.199349098746416 3834 41316311
SGTC_1995 st072814 61.1 µM -0.844715041610159 0.190732179042727 no 2707 0.199134979606426 3888 5769371
SGTC_2721 ifenprodil 61.44 µM -0.847123447368568 0.190071665349904 no 2708 0.198463158556363 3875 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2246 7293507 91.5585 µM -0.851951788251967 0.1887517167049 no 2709 0.197120425648269 3954 887656
SGTC_1315 1237-0019 3.69 µM -0.852563963854765 0.188584767568856 no 2710 0.196950576803534 3923 825140
SGTC_753 1322-0200 289 µM -0.852810593515334 0.188517533831385 no 2711 0.196882174156032 3962 5403907
SGTC_1634 st006576 41 µM -0.853097178101085 0.188439426547019 no 2712 0.196802708094543 3880 3915356
SGTC_1277 0873-0036 22 µM -0.853112288245798 0.188435308901952 no 2713 0.196798518793194 3972 5965735
SGTC_2374 9071832 200 µM -0.853370858657376 0.188364854829539 no 2714 0.196726838280816 3831 17381698
SGTC_2959 9079155 11 µM -0.854070161867971 0.188174393330926 no 2715 0.196533057692238 3959 16189457
SGTC_2229 7354935 190 µM -0.854436774198007 0.188074590676528 no 2716 0.196431513718873 3830 318112
SGTC_2394 5221648 200 µM -0.859196778983726 0.186781745078401 no 2717 0.19511598007634 3987 788586
SGTC_1944 st076371 56.9 µM -0.860205155140884 0.186508571844375 no 2718 0.194837981739756 3910 24208455
SGTC_3103 9120822 49.47 µM -0.860238289888999 0.186499599706132 no 2719 0.194828850940025 3919 17141819
SGTC_1394 3474-0001 65.7 µM -0.861080838892007 0.186271546370742 no 2720 0.194596760797729 3912 5017666 YIL048W NEO1
SGTC_1880 MG-132 525 µM -0.861961338586685 0.186033405624735 no 2721 0.194354396550964 3854 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_866 0495-0101 262 µM -0.863000774211155 0.185752521968224 no 2722 0.194068520638262 3869 635694
SGTC_3244 9134489 49.47 µM -0.863285589697982 0.185675603052096 no 2723 0.193990232590422 3946 16584271
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.864603969669369 0.185319811246491 no 2724 0.193628096484384 3866 140250 A respiratory chain inhibitor.
SGTC_1318 1280-3875 124 µM -0.865385570361688 0.185109080315256 no 2725 0.193413599115759 3945 373245
SGTC_290 2043-6722 48.1 µM -0.866247617641586 0.184876832505765 no 2726 0.193177192708165 3945 773758 YLR208W SEC13
SGTC_2104 5389443 200 µM -0.867024359113255 0.184667722467331 no 2727 0.192964331561175 3987 2244536
SGTC_1688 st021091 57.6 µM -0.869669432096397 0.183956734243181 no 2728 0.192240540930569 3934 3656366
SGTC_849 0386-0493 241 µM -0.869815470196245 0.183917529326994 no 2729 0.192200627892209 3881 726119
SGTC_2227 7312221 64.1025 µM -0.870121717898716 0.183835331957046 no 2730 0.192116945126715 3976 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_840 0245-0196 390 µM -0.871560596251789 0.183449441103652 no 2731 0.191724067393088 4033 3827528
SGTC_3333 9141820 12.094 µM -0.87638044443464 0.182160494880197 no 2732 0.190411622887405 3936 1939433
SGTC_1209 2323-2347 50.3 µM -0.87675094064407 0.182061649907327 no 2733 0.190310965658418 3915 5412760
SGTC_656 4090-1979 187 µM -0.878705115664375 0.181540849082374 no 2734 0.18978059210109 3977 22330961
SGTC_529 4076-0302 30.3 µM -0.880398879727112 0.181090204666489 no 2735 0.189321631592364 3895 5816522
SGTC_104 0074-0074 590.992 µM -0.882232606186484 0.180603112540054 no 2736 0.188825516367435 3742 3943124
SGTC_2264 7948757 110.76 µM -0.88518521403209 0.179820540783025 no 2737 0.188028372843656 3906 2971411
SGTC_977 1348-1378 135 µM -0.886177905070021 0.179557912896049 no 2738 0.187760833931687 3950 X977
SGTC_1028 k015-0029 4.8 µM -0.886879245023054 0.179372510706918 no 2739 0.187571958495667 3906 4588309
SGTC_3084 9116877 49.47 µM -0.889081525024674 0.178791111413117 no 2740 0.186979633591449 3825 27241325
SGTC_107 0358-0022 2.6945 µM -0.889675937715723 0.178634390704733 no 2741 0.186819958983521 3986 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_674 0498-0004 451 µM -0.890984066521694 0.17828979895743 no 2742 0.186468859118629 3958 4231473
SGTC_800 3448-7362 155 µM -0.8911493185735 0.178246297519302 no 2743 0.186424534801923 4025 15991913
SGTC_2250 alverine citrate 130 µM -0.891166438833714 0.178241791113879 no 2744 0.186419943136229 3856 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1079 idarubicin 2.36 µM -0.891335630996036 0.178197260110019 no 2745 0.186374569447798 3954 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_93 0109-0045 59.227 µM -0.893615374213179 0.177597920663421 no 2746 0.185763858813787 4044 88733
SGTC_2741 miltefosine 3.04 µM -0.894088720999578 0.177473638510262 no 2747 0.185637211773505 3927 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_394 menadione 8.33 µM -0.894530168651 0.177357781296681 no 2748 0.1855191478483 3955 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1971 st069429 63.5 µM -0.894578703557306 0.17734504630438 no 2749 0.185506170169012 3952 1246522 YGL099W LSG1
SGTC_3218 9131285 49.47 µM -0.89459811109246 0.177339954155526 no 2750 0.185500980973602 3910 17156417
SGTC_1509 1326-1131 80 µM -0.896524377857765 0.176834999671073 no 2751 0.184986383209415 3856 768313
SGTC_940 3232-1287 54.8 µM -0.902887814817651 0.175173346914354 no 2752 0.183292719175758 3862 1585493 YIL048W NEO1
SGTC_1463 k081-0032 34.1 µM -0.90802838169599 0.173838272104195 no 2753 0.181931613392107 3704 977755
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.908632969678377 0.173681678835739 no 2754 0.181771948633066 4066 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2128 5255449 168.493 µM -0.910943093995451 0.17308416450263 no 2755 0.181162679000567 3976 736008
SGTC_1052 3253-3998 198 µM -0.91392185864109 0.172315641349046 no 2756 0.180378953495411 3932 5450317
SGTC_1171 0368-0077 21.4 µM -0.914814406402123 0.172085788006141 no 2757 0.180144535237577 3935 3239779
SGTC_2964 9083345 53.42 µM -0.915093511468902 0.172013951665006 no 2758 0.180071270502645 3989 17741579
SGTC_1812 st052057 4.327 µM -0.916686756662402 0.171604247241911 no 2759 0.179653403879462 4006 3645418
SGTC_1658 st012944 20 µM -0.916784349745445 0.171579171374848 no 2760 0.179627827581803 3881 24207260
SGTC_1289 0976-0073 69.1 µM -0.917701280734272 0.171343686649514 no 2761 0.179387638493262 4047 3391136
SGTC_1169 aniline yellow 25.8 µM -0.917762177622342 0.171328054529405 no 2762 0.179371693772658 3926 6051 A DNA damaging agent.
SGTC_2222 6885208 172.143 µM -0.918595042918449 0.171114351034426 no 2763 0.179153712881913 3922 609514
SGTC_187 1488-2104 32.728 µM -0.919099817610933 0.170984914759182 no 2764 0.179021682331107 3990 2852859
SGTC_1495 4469-0029 237 µM -0.92220255494463 0.17019067513377 no 2765 0.178211465330327 4000 793680
SGTC_398 bronopol 33.3 µM -0.922579694375065 0.170094296258045 no 2766 0.178113140781122 3895 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_153 4077-0274 519.67 µM -0.923024255044684 0.169980732651493 no 2767 0.177997282670451 3992 3121976
SGTC_994 3910-0338 138 µM -0.924244784297997 0.169669196813857 no 2768 0.177679441767449 4093 3479481
SGTC_1630 st005209 31.3 µM -0.92711005317985 0.168939287013123 no 2769 0.176934698500132 3946 3367314
SGTC_362 0310-0100 9.03 µM -0.927148986340431 0.16892938293822 no 2770 0.176924592561462 4084 790235
SGTC_516 3992-2719 87.3 µM -0.928554067322358 0.168572198792917 no 2771 0.176560117749557 3942 5350887 YDR037W KRS1
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.929870640866451 0.168237954957429 no 2772 0.176219032822867 3988 688667
SGTC_102 gallobenzophenone 83.616 µM -0.930211549627822 0.168151476611783 no 2773 0.176130781549373 3999 70837
SGTC_1049 3226-0134 66 µM -0.931018936120315 0.167946780933509 no 2774 0.175921884493149 4047 5702385
SGTC_1042 0350-0096 82 µM -0.932158636578426 0.167658107236765 no 2775 0.175627274219382 3999 3122515
SGTC_2082 5219693 150 µM -0.932244557096319 0.167636357468129 no 2776 0.175605076618458 4003 2834649
SGTC_1791 st048313 56.1 µM -0.932302607781975 0.167621663648487 no 2777 0.175590080206494 4024 1204976
SGTC_1831 st055328 12 µM -0.934725941486193 0.167009008369368 no 2778 0.174964777151771 4010 1103068
SGTC_2826 7992541 19.48 µM -0.936502027681881 0.166560905223259 no 2779 0.174507384533811 4030 2985066
SGTC_33 0986-0033 35.816 µM -0.936721936671035 0.166505476648834 no 2780 0.174450804608882 3923 2848082
SGTC_3225 9130819 49.47 µM -0.939290240935599 0.165859011314593 no 2781 0.173790873886558 3956 4547121
SGTC_967 1306-0166 352 µM -0.942821253575118 0.164972875839015 no 2782 0.172886169339423 3993 4437607
SGTC_882 0843-0131 351 µM -0.943789192714156 0.164730500228092 no 2783 0.17263869217745 3990 5425421
SGTC_3033 9090887 49.47 µM -0.943868490685461 0.164710653945997 no 2784 0.172618427738555 4047 19325384
SGTC_450 aminopyrene 156 nM -0.945239234169618 0.164367836264541 no 2785 0.172268376682031 3922 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2689 tacrolimus 100 µM -0.945384091721492 0.164331634991696 no 2786 0.172231410434947 4049 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_837 0091-0265 12.5 µM -0.947823537374276 0.163722771074474 no 2787 0.171609647957248 3972 759367
SGTC_1712 st032288 53.4 µM -0.948412712646135 0.163575938004074 no 2788 0.171459695065382 3948 2883011
SGTC_3307 9126885 69.2785 µM -0.949026600811245 0.16342303702814 no 2789 0.171303541527294 4011 24824909
SGTC_2139 5578692 56.4705 µM -0.95026335391258 0.163115281230589 no 2790 0.17098922723167 3987 650991 YMR113W FOL3
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.953042370755653 0.162425120901187 no 2791 0.170284301577762 4087 94937 An inhibitor of serotonin biosynthesis.
SGTC_2840 9008771 71.43 µM -0.9554368144412 0.161831994581763 no 2792 0.169678422123062 3984 2992978
SGTC_261 5-fluorouridine 15.376 µM -0.956551436732191 0.161556374104877 no 2793 0.169396855257546 4025 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2497 7-hydroxyflavone 100 µM -0.957331824058884 0.161363584500239 no 2794 0.169199898698536 4078 5281894
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.957592711277354 0.16129916749099 no 2795 0.169134087983317 4056 2374 Ca(2+)-ATPase inhibitor.
SGTC_3288 9119690 36.221 µM -0.959570580638209 0.160811347268805 no 2796 0.168635690692593 4040 17595618 YKL019W RAM2
SGTC_171 k064-0041 9.68 µM -0.964014346079175 0.159718857253327 no 2797 0.167519366716309 4075 53325
SGTC_671 0560-0003 407 µM -0.964687098309341 0.159553886833661 no 2798 0.16735077963617 3949 3238678
SGTC_3108 9121785 49.47 µM -0.966379446497627 0.159139387273711 no 2799 0.16692717247771 3898 17140271
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.967784643548272 0.158795754887241 no 2800 0.166575967357069 4084 4174840
SGTC_1003 4049-0218 100 µM -0.968653554847439 0.158583511467127 no 2801 0.166359036558831 4090 295161
SGTC_2426 5582046 32.21 µM -0.968914561448287 0.158519793399358 no 2802 0.166293909775131 4067 2251934
SGTC_2761 levamisole 97.89 µM -0.969036363371634 0.158490064330475 no 2803 0.166263523200419 4007 26879 An alkaline phosphatase inhibitor.
SGTC_3226 9131256 49.47 µM -0.97216202899785 0.157728411793049 no 2804 0.165484973692475 3980 17178073
SGTC_469 w7 172 µM -0.974735090396193 0.157103223415746 no 2805 0.164845841007397 4117 45115570 A P450 inhibitor.
SGTC_1461 k072-0203 53.8 µM -0.974930634768416 0.157055777840139 no 2806 0.164797334438338 3962 5418714
SGTC_1322 1348-1070 12 µM -0.975069573395394 0.157022072430782 no 2807 0.164762875060774 4058 6758089
SGTC_316 k060-0003 58.6 µM -0.977662478422573 0.156393927237524 no 2808 0.164120642614707 4084 6152314
SGTC_207 4185-0010 4.486 µM -0.980004218538869 0.155828052253154 no 2809 0.163542018154415 4114 3761753
SGTC_2235 salicylic acid 500 µM -0.981045057890827 0.155576970207281 no 2810 0.163285261204357 4092 338 A COX inhibitor and kinase inhibitor.
SGTC_1490 4089-0339 670 nM -0.982780414165962 0.155158943297093 no 2811 0.162857761682929 4001 742542
SGTC_2656 pseudo-anisatin 100 µM -0.988305593959869 0.153832935677902 no 2812 0.161501503309003 4102 6708809 A neurotoxin.
SGTC_229 benomyl 22.8748 µM -0.988389380367499 0.153812885383411 no 2813 0.161480993220579 4090 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2738 aclarubicin 5.55 µM -0.990050472708566 0.153415738967052 no 2814 0.161074724776052 4034 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1106 tegaserod maleate 11.7 µM -0.993942303621366 0.152487913131433 no 2815 0.16012547872672 4082 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1229 0139-0193 12.2 µM -0.994665967014275 0.152315800723052 no 2816 0.159949376005665 4154 3090752
SGTC_2176 5809774 33.9695 µM -0.995135672122267 0.152204157496988 no 2817 0.159835141578647 4041 2870539
SGTC_2980 9014342 25.29 µM -0.996705769452182 0.151831358792998 no 2818 0.159453674209164 4151 2996599
SGTC_2141 5621638 7.665 µM -1.00172492238204 0.150643700495695 no 2819 0.158238233187428 4115 2856238
SGTC_106 0092-0003 11.579 µM -1.00823846543955 0.14911167971694 no 2820 0.156669997943738 3995 1072148
SGTC_759 3486-0358 89.3 µM -1.00996783859484 0.148706676141271 no 2821 0.156255349446295 4101 875103
SGTC_51 1013-0126 23.419 µM -1.01006961335346 0.148682864343195 no 2822 0.156230969652255 4065 1627850
SGTC_925 2064-1272 59.6 µM -1.01151402066984 0.148345197413508 no 2823 0.155885237007018 4084 6815817
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.01193469420918 0.148246950805456 no 2824 0.155784639701707 4085 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2620 irigenin 100 µM -1.01452161606529 0.147643742722224 no 2825 0.155166960147429 4154 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2780 5215298 71.43 µM -1.01582121201411 0.14734132937986 no 2826 0.15485726647498 4150 2834131
SGTC_2946 9065502 71.43 µM -1.01783065417022 0.146874553952096 no 2827 0.154379220738148 3915 16489101
SGTC_1452 4194-0072 190 µM -1.01882155394008 0.146644742357772 no 2828 0.154143845539718 4178 1343545
SGTC_421 streptovitacin 30 mM -1.02058708912142 0.146235873943782 no 2829 0.153725054466934 4179 91467 include heat shock
SGTC_2845 9003024 42.97 µM -1.02317663522276 0.145637564573007 no 2830 0.153112168987937 4185 2990173
SGTC_2444 5485484 36.41 µM -1.02590891393504 0.145008063932074 no 2831 0.152467260281133 4204 6790631
SGTC_2019 4016004 108 µM -1.02689222364051 0.144781964127629 no 2832 0.152235608213571 4148 45595336
SGTC_1608 st001473 40.5 µM -1.02710374161049 0.144733359252303 no 2833 0.152185808511672 4088 7292267
SGTC_1488 4013-0813 75.9 µM -1.02793643378407 0.144542121082471 no 2834 0.151989864936219 4048 2910057
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.02828010972672 0.144463241259713 no 2835 0.151909042278456 4149 6728940
SGTC_2847 9005661 71.43 µM -1.02854044948236 0.144403507906092 no 2836 0.151847836895296 4109 2991449
SGTC_2125 5246583 200 µM -1.02971924095873 0.144133249791346 no 2837 0.151570910327973 4126 835267
SGTC_617 3770-0098 35 µM -1.02995432112741 0.144079394454697 no 2838 0.151515724500678 4049 5962639
SGTC_1877 wortmannin 25 µM -1.0303514639082 0.143988442458144 no 2839 0.151422524303104 4126 312145 A covalent inhibitor of PI 3-kinase.
SGTC_321 4534-3890 65.3 µM -1.03047286376192 0.143960647695255 no 2840 0.151394042182964 4127 699746
SGTC_1911 st060208 74.3 µM -1.03192577830968 0.143628280546883 no 2841 0.151053444384859 4174 688783
SGTC_2353 9059630 146.67 µM -1.03308281333912 0.143363969184451 no 2842 0.150782572783507 4167 4779114
SGTC_1368 1852-0141 284 µM -1.03560327836374 0.1427893355128 no 2843 0.1501936309559 4140 2838987
SGTC_2772 vinpocetine 57.06 µM -1.03946393070608 0.141912178895517 no 2844 0.149294512335513 4171 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1157 4092-0394 27.6 µM -1.04097356582855 0.141570177713576 no 2845 0.148943908394803 4228 3659885
SGTC_1450 4112-4260 37.6 µM -1.04154390709614 0.141441114870856 no 2846 0.148811593256777 4125 1633175
SGTC_1058 3448-5425 97.3 µM -1.04233762428761 0.141261636899745 no 2847 0.14862758724952 4038 7279705
SGTC_533 1222-0222 6.71 µM -1.04285057424403 0.141145729113887 no 2848 0.148508751946125 4175 3982874
SGTC_850 0388-0143 75.9 µM -1.04301102206308 0.141109487063889 no 2849 0.148471593989762 4107 67273
SGTC_1031 k035-0009 16 µM -1.04417972370745 0.14084569042536 no 2850 0.148201123086323 4203 5180959
SGTC_1797 st048695 56.8 µM -1.04457845077815 0.140755767265806 no 2851 0.148108921735824 4116 592262 YIL048W NEO1
SGTC_1415 3966-0071 78.1 µM -1.04626898987916 0.140374940227593 no 2852 0.14771842920102 4068 2893185
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.04642442802239 0.140339959897954 no 2853 0.147682559655941 4142 1377
SGTC_2405 ticlatone 3.52 µM -1.04659203106259 0.140302248571455 no 2854 0.147643889425796 3983 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2428 5615643 7.78 µM -1.04709443146397 0.140189247791718 no 2855 0.147528013674623 4180 2253075
SGTC_2486 5283202 22.39 µM -1.0486192572881 0.13984665993229 no 2856 0.147176694562436 4193 1377751
SGTC_2745 rifampicin 24.3 µM -1.04952396169544 0.139643666078242 no 2857 0.146968516430252 4170 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_23 0213-0011 39.996 µM -1.05090265831329 0.139334705281318 no 2858 0.146651649683352 4152 627608
SGTC_1208 2323-2347 50.3 µM -1.05114223169194 0.139281065241927 no 2859 0.146596635164491 4163 5412760
SGTC_2591 skatole 100 µM -1.05131942005342 0.139241402133384 no 2860 0.146555955362722 4169 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2688 kanamycin b 96.69 µM -1.05153242240403 0.139193732339808 no 2861 0.146507063233133 4204 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1000 4048-0884 8.67 µM -1.05220770781955 0.139042677310127 no 2862 0.146352131964378 4180 13040088
SGTC_926 2268-1401 59.4 µM -1.05230068345677 0.139021888273028 no 2863 0.146330809109121 4114 2931578
SGTC_601 0986-0029 62.9 µM -1.05230201393738 0.139021590797433 no 2864 0.146330503994375 4090 24747981
SGTC_1501 4491-0275 38.4 µM -1.05281622138352 0.138906654137516 no 2865 0.146212614476622 4122 5104718
SGTC_1510 1123-0200 71.5 µM -1.05427056317032 0.138581927164786 no 2866 0.145879530935144 4196 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_246 cycloheximide 667 µM -1.05496160352629 0.138427812348831 no 2867 0.145721442885865 4033 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1715 st032160 10.2275 µM -1.05725665366109 0.137916811960971 no 2868 0.14519723506319 4085 5289825
SGTC_830 4076-0286 57.8 µM -1.06113164417497 0.137056956323473 no 2869 0.144315039362505 4221 6866659
SGTC_2108 5365811 200 µM -1.06234967668327 0.136787434647539 no 2870 0.144038485114378 4163 780283
SGTC_3049 9092223 49.47 µM -1.06309648024614 0.136622364038376 no 2871 0.143869100241234 4140 8623917
SGTC_1799 st045822 46.1415 µM -1.06478240700622 0.136250214243326 no 2872 0.143487204130516 4131 3674992
SGTC_1879 gemcitabine 100 µM -1.06613377818638 0.135952415197439 no 2873 0.143181586102266 4131 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2048 5246248 200 µM -1.06735607111448 0.135683444964756 no 2874 0.142905538608084 4184 677046
SGTC_368 fentichlor 4.58 µM -1.07176708146459 0.134715817842234 no 2875 0.141912331066025 4207 7329 A pesticide.
SGTC_497 capsazepine 133 µM -1.07356460652434 0.134322862705073 no 2876 0.141508933935777 4121 2733484 A calcium channel blocker.
SGTC_1955 wogonin 32.4 µM -1.07372989035785 0.134286769730062 no 2877 0.141471880300722 4233 5281703 A flavanone.
SGTC_3125 9127534 49.47 µM -1.07848841735495 0.133250507325497 no 2878 0.140407923992548 4071 1639235
SGTC_814 3342-0569 96 µM -1.07934642464523 0.13306424652233 no 2879 0.140216662288698 4249 4346283
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.07961448104142 0.133006092166352 no 2880 0.140156945103683 4149 6708739 YPR165W RHO1
SGTC_1293 1000-1278 195 µM -1.08227038212593 0.132430844588498 no 2881 0.139566201248834 4215 678847
SGTC_112 phenothiazine 287.218 µM -1.08366630931622 0.132129185946602 no 2882 0.139256389333716 4130 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2549 cedrol 20.94 µM -1.0837068287157 0.132120436821397 no 2883 0.139247403457495 4129 6708665 A sedative which affects the nervous system.
SGTC_1065 prochlorperazine maleate 2.48 µM -1.08481369674534 0.131881591544443 no 2884 0.139002088965477 4209 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1139 k015-0024 46.9 µM -1.08627366005562 0.131567009448536 no 2885 0.138678968397764 4202 2766652
SGTC_2543 pimpinellin 60.67 µM -1.08630032670478 0.131561268336713 no 2886 0.138673071269839 3993 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2146 5545642 200 µM -1.0891185776234 0.130955496529887 no 2887 0.138050799248106 4135 825326
SGTC_1856 st057054 55.7 µM -1.08934247939222 0.13090745251478 no 2888 0.138001443347822 4196 1266018
SGTC_2160 5660466 132.927 µM -1.09083165827154 0.130588219927161 no 2889 0.13767348168015 4089 2859134
SGTC_379 3970-0972 5.9 µM -1.0922355379428 0.130287766070285 no 2890 0.137364792907429 4183 2898042 YBL034C STU1
SGTC_2217 6934799 96.0675 µM -1.09254698812026 0.130221175365186 no 2891 0.137296374526654 4160 675606
SGTC_835 0312-0010 67.2 µM -1.09333247819208 0.130053335489807 no 2892 0.137123923954024 4171 1626196
SGTC_756 0508-1999 28.3 µM -1.09396249065432 0.129918825597476 no 2893 0.136985714728984 4196 6753853
SGTC_1570 verbenone 133 µM -1.09442481072547 0.129820179915332 no 2894 0.136884353664106 4213 29025 A natural terpanoid with antifungal properties.
SGTC_1243 0416-0003 5.65 µM -1.09642891538342 0.129393161918464 no 2895 0.136445557854155 4172 2141977
SGTC_1329 1447-1697 50.6 µM -1.09785019253463 0.129090918497195 no 2896 0.136134955021026 4211 2840515
SGTC_2799 7812892 81.82 µM -1.09876816613293 0.128895966081901 no 2897 0.135934600464927 4221 20205235
SGTC_3124 9127567 49.47 µM -1.09911825641524 0.128821670324766 no 2898 0.135858243866775 4181 17592030
SGTC_2295 7971645 200 µM -1.09952498696523 0.128735391746211 no 2899 0.13576957060652 4250 2978226 YKL099C UTP11
SGTC_82 0054-0107 293.755 µM -1.10167432674602 0.128280124244633 no 2900 0.135301641079916 4153 3104697
SGTC_1881 5652484 16 µM -1.10192090364862 0.128227966546995 no 2901 0.13524802996589 4185 2255129
SGTC_819 1013-0258 27.7 µM -1.1021152339049 0.128186870809214 no 2902 0.135205788657298 4198 5753198
SGTC_2489 cantharidin 73.42 µM -1.10296944691268 0.128006335703225 no 2903 0.13502021678598 4148 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1515 3460-0031 42.1 µM -1.10412700258503 0.127761972106999 no 2904 0.134769024677541 4138 2876596
SGTC_2437 5741531 144.16 µM -1.10444494152534 0.127694911002898 no 2905 0.134700087400249 4224 2262990
SGTC_2652 actinonin 100 µM -1.10634645317552 0.127294346434794 no 2906 0.134288296321405 4210 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_144 4161-2749 112.381 µM -1.10803088847329 0.126940241070846 no 2907 0.133924238112708 4148 797501 YMR168C CEP3
SGTC_2746 daunorubicin 9.88 µM -1.10911869967304 0.126711923928759 no 2908 0.133689489472919 4148 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1670 st016595 4.04 µM -1.10943043528209 0.126646547508351 no 2909 0.133622269403409 4228 597879
SGTC_2463 5473429 200 µM -1.10949660536662 0.126632673504926 no 2910 0.133608004028289 4184 5399405
SGTC_763 3453-1109 128 µM -1.11223074226182 0.126060327300604 no 2911 0.133019476574409 4218 1560353
SGTC_234 nsc-17383 10.7 µM -1.11415012732911 0.125659614870993 no 2912 0.13260739341685 4230 408974
SGTC_1861 st057647 17.4 µM -1.11674096166207 0.125120133798007 no 2913 0.132052549195092 4300 688668
SGTC_1493 4348-0038 111 µM -1.11784698519313 0.124890323437317 no 2914 0.131816175259102 4182 800424
SGTC_3335 9143315 29.6265 µM -1.11867262112905 0.124718964561774 no 2915 0.131639914779079 4208 4899691
SGTC_1059 3448-6867 171 µM -1.12143664274929 0.124146494226461 no 2916 0.131051023038024 4171 3934407
SGTC_2928 9011484 9.79 µM -1.12146248738423 0.124141150104154 no 2917 0.131045525282421 4227 2994751
SGTC_376 3970-0862 59.1 µM -1.12374303742993 0.123670214287743 no 2918 0.130561026468601 4254 3135186
SGTC_3355 9151058 44.0485 µM -1.12445913038098 0.12352259879118 no 2919 0.130409149644062 4216 17015728
SGTC_2287 7945887 168.79 µM -1.1279864188669 0.122797284259725 no 2920 0.129662827409061 4238 1245853
SGTC_2158 5657123 3.6195 µM -1.12810654008114 0.122772636497025 no 2921 0.129637463725023 4184 2858827
SGTC_230 MPP+ 141.667 µM -1.12896891313309 0.122595787388728 no 2922 0.129455473909468 4180 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_138 0850-0259 40.9225 µM -1.13099828223441 0.122180324688678 no 2923 0.129027907215713 4167 6813004
SGTC_3136 9095672 49.47 µM -1.13160265551474 0.122056785590041 no 2924 0.128900761586473 3957 17217380
SGTC_2614 arthonioic acid 13.39 µM -1.1362506851578 0.121109619453393 no 2925 0.127925831703696 4089 6710684
SGTC_3230 9131665 49.47 µM -1.13649417389313 0.121060144723928 no 2926 0.127874901252592 4192 15943720
SGTC_2040 5100729 123 µM -1.13927761068671 0.120495585461027 no 2927 0.127293691849773 4251 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_553 k007-0256 45.7 µM -1.14265402899019 0.119813244788567 no 2928 0.126591131810836 4296 6287000
SGTC_1644 st010134 20.9 µM -1.143088727636 0.119725594853412 no 2929 0.12650087699126 4215 3818134
SGTC_3042 9091578 49.47 µM -1.14686849357885 0.118965371971913 no 2930 0.12571798792404 4212 25236497
SGTC_612 0302-0167 22.4 µM -1.15344532527393 0.117650714844184 no 2931 0.124363823348735 4244 235821
SGTC_281 1672-3440 14.9 µM -1.15364725745242 0.117610513544562 no 2932 0.124322407698468 4294 6833000
SGTC_3020 9089140 49.47 µM -1.15458126384841 0.117424695089914 no 2933 0.124130971439531 4259 17217859
SGTC_3324 9138759 60.749 µM -1.15567395680208 0.117207570290594 no 2934 0.123907272279553 4284 45595710
SGTC_543 3844-1095 191 µM -1.15604888743527 0.117133134846495 no 2935 0.123830580487738 4252 4230703
SGTC_1689 st020265 53.493 µM -1.15870878005437 0.116606024583871 no 2936 0.123287455367888 4258 5758320 YPR016C TIF6
SGTC_2480 5767542 37.17 µM -1.16207948856318 0.115940471544933 no 2937 0.12260158914481 4186 2867358
SGTC_1275 0867-0008 21.1 µM -1.16413207562195 0.11553650784378 no 2938 0.122185245805411 4216 3422836
SGTC_1374 2889-5571 141 µM -1.16708208806701 0.114957677488682 no 2939 0.121588610331638 4296 2853281
SGTC_1061 3448-9325 110 µM -1.16912948052466 0.114557167113703 no 2940 0.121175733937891 4211 723482
SGTC_2587 piperic acid 92.2 µM -1.17088147632623 0.114215231518352 no 2941 0.120823210898769 4249 5370536
SGTC_2242 6630449 61.2675 µM -1.17450214938896 0.113510892351565 no 2942 0.120096975760544 4310 691249 YDR170C SEC7
SGTC_42 0133-0086 60.653 µM -1.17451195259386 0.113508989521701 no 2943 0.120095013617191 4146 162923 Model of phenazepam hydroxylation.
SGTC_2612 dictamnine 15.46 µM -1.17755007433405 0.112920376868055 no 2944 0.119488011732107 4195 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_113 0099-0221 2.5 µM -1.18220636975224 0.112022489460545 no 2945 0.118561912910347 4234 89219
SGTC_2381 9035592 200 µM -1.18631297675038 0.111234846165953 no 2946 0.117749361910401 4281 4749657
SGTC_1363 1636-0063 10.4 µM -1.18843773284673 0.110828879948387 no 2947 0.117330498983114 4281 6072185
SGTC_3304 9125678 46.087 µM -1.18929905601662 0.110664614105357 no 2948 0.117161003339274 4206 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1399 3562-5772 25 µM -1.18971311099547 0.110585710416142 no 2949 0.117079585217653 4257 23847490
SGTC_1657 st012939 43.4 µM -1.18996098758886 0.110538493531284 no 2950 0.117030862939571 4285 24207257
SGTC_1977 st070720 65.3 µM -1.19281564162491 0.109995764772975 no 2951 0.116470791420843 4309 682188
SGTC_981 1488-1094 54.9 µM -1.19373870537169 0.109820681027897 no 2952 0.116290097496825 4245 3449522
SGTC_599 1935-0052 86.5 µM -1.19606528377113 0.109380270838822 no 2953 0.115835541939662 4276 9557311
SGTC_1687 st020778 55.3625 µM -1.19963457050589 0.108707090289753 no 2954 0.115140647093053 4295 4259299
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.20112941027498 0.108426045053299 no 2955 0.114850503093873 4241 6708514
SGTC_1808 st050063 61.5 µM -1.20396711245604 0.107893966861921 no 2956 0.114301145069259 4275 4011993
SGTC_1457 k015-0032 57.3 µM -1.20503425506372 0.10769436156758 no 2957 0.114095039103195 4273 4302660
SGTC_878 0828-0289 13.7 µM -1.20532003204868 0.107640953171612 no 2958 0.114039889628069 4237 745350 YLR208W SEC13
SGTC_844 0330-0132 15.3 µM -1.2056398703725 0.107581201741646 no 2959 0.11397818949162 4323 2828079
SGTC_3111 9122088 49.47 µM -1.21344030164126 0.106131336366803 no 2960 0.112480762863149 4155 16876704
SGTC_1910 st062352 60.4 µM -1.21446535523705 0.105941864148317 no 2961 0.112285035843514 4204 2245730
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.21692615501544 0.105488004855794 no 2962 0.111816156631254 4320 6708760
SGTC_2796 7949634 45.45 µM -1.21994776202566 0.104932638290412 no 2963 0.111242339113973 4276 2971588
SGTC_1101 ebselen 5.29 µM -1.22224046457072 0.104512657808822 no 2964 0.110808352925855 4325 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3176 9106582 49.47 µM -1.22536909865887 0.103941516896951 no 2965 0.110218092173299 4277 17018027
SGTC_1324 1418-0026 34.4 µM -1.22747444567466 0.103558456111893 no 2966 0.109822160377372 4349 1372513
SGTC_803 4488-1585 147 µM -1.23958887145155 0.101374173312338 no 2967 0.107563749452402 4315 747204
SGTC_1348 1493-0373 93.8 µM -1.24086746059503 0.101145611087813 no 2968 0.107327357541074 4342 3010129
SGTC_375 3970-0961 9.27 µM -1.24120111369876 0.101086028669807 no 2969 0.10726573176289 4263 2898222
SGTC_141 0443-0274 32.331 µM -1.24166307972197 0.101003574887012 no 2970 0.10718044869008 4290 1627241
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.24456214813299 0.100487255066319 no 2971 0.106646370688269 4316 616764
SGTC_396 dithiazanine 1.25 µM -1.24466464714642 0.100469035454465 no 2972 0.106627523129718 4310 10578 An antihelmenthic.
SGTC_1810 st050138 53 µM -1.24506296812975 0.100398255181097 no 2973 0.106554302537806 4329 3444541
SGTC_1084 voriconazole 435 nM -1.2520228651361 0.0991673725960756 no 2974 0.10528076618105 4341 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1308 1187-1617 41.4 µM -1.25517901108884 0.0986128482804954 no 2975 0.104706891541197 4350 2882570
SGTC_2839 9003951 25.97 µM -1.2554246197967 0.0985697910306606 no 2976 0.104662328279296 4385 2990634
SGTC_1451 4152-0210 104 µM -1.25665941370885 0.098353529901647 no 2977 0.104438495312006 4369 659563
SGTC_2575 plumbagin 510 nM -1.25863746976061 0.0980078187427919 no 2978 0.104080653290069 4240 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1686 st019653 115.5 µM -1.25892969716053 0.0979568208150274 no 2979 0.104027863084129 4317 97252
SGTC_895 0964-0006 13.7 µM -1.260890171854 0.0976151922798173 no 2980 0.103674209820178 4328 6738897
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.26133830795536 0.0975372237738594 no 2981 0.103593492442194 4339 688751
SGTC_4 0960-0234 25.671 µM -1.26195869527437 0.0974293617067887 no 2982 0.103481824798063 4344 6821112
SGTC_154 3389-1638 511.116 µM -1.26204410786294 0.0974145185186329 no 2983 0.103466457662183 4333 5238686
SGTC_1406 3909-7906 11.9 µM -1.26370979713258 0.0971253828864525 no 2984 0.103167103689145 4371 X1406
SGTC_632 0781-2353 4.65 µM -1.26653406320533 0.0966365779599106 no 2985 0.102660971069121 4395 6811515 YHR007C ERG11
SGTC_279 1273-0055 2.93 µM -1.26930530585905 0.0961587087436712 no 2986 0.102166097354494 4369 2847562
SGTC_1172 0370-0043 85 µM -1.26947148256215 0.0961301087722347 no 2987 0.102136477653367 4370 376585
SGTC_3272 9137413 49.47 µM -1.27016456871279 0.0960108920717997 no 2988 0.10201300781816 4253 17614870
SGTC_2387 9077560 195.08 µM -1.27046902938036 0.0959585566352381 no 2989 0.101958804019474 4354 5303272
SGTC_1020 4335-0961 93.3 µM -1.2707284762909 0.095913975422384 no 2990 0.101912630661192 4303 669075
SGTC_2852 9023854 51.95 µM -1.27097698226515 0.0958712884942125 no 2991 0.101868418715145 4371 19798528
SGTC_1433 4060-0023 7.6 µM -1.27255663611953 0.095600271310769 no 2992 0.101587707301188 4366 3840627
SGTC_3292 9120825 59.784 µM -1.27336512429451 0.0954617793640689 no 2993 0.101444253529403 4333 24824900
SGTC_31 0508-1974 57.237 µM -1.27468475857454 0.0952360467188337 no 2994 0.101210421823067 4278 6810525
SGTC_842 0271-0008 11.1 µM -1.27603613223353 0.095005292413664 no 2995 0.100971373370711 4384 1221709
SGTC_1430 4049-0248 69.1 µM -1.27607596837889 0.0949984964329105 no 2996 0.100964332888808 4368 22774488
SGTC_319 1348-1596 45.5 µM -1.27647327350517 0.0949307364283406 no 2997 0.10089413434394 4423 5380505
SGTC_2077 5212015 200 µM -1.27705967889718 0.0948307906277274 no 2998 0.100790589322894 4249 780900
SGTC_898 1000-0849 28.3 µM -1.27941262830246 0.0944305381694463 no 2999 0.100375894589607 4362 6751807
SGTC_5 0352-0601 109.883 µM -1.28121028649813 0.094125584878894 no 3000 0.100059907001925 4251 762456
SGTC_2995 9067767 71.4286 µM -1.28181473872271 0.0940232094866218 no 3001 0.0999538213345425 4362 11673567
SGTC_2958 9077254 16.72 µM -1.28693990368533 0.0931584660365313 no 3002 0.0990576177361643 4413 16457351
SGTC_468 gf-109203x 121 µM -1.28718662143031 0.093116987354679 no 3003 0.0990146245991817 4391 2396 A protein kinase C inhibitor.
SGTC_1177 0983-0204 23.6 µM -1.28803372944153 0.0929746737447451 no 3004 0.0988671110968022 4384 766818
SGTC_2059 5238311 157 µM -1.29203326670656 0.0923049252308999 no 3005 0.0981728121366437 4315 703021
SGTC_1780 st038448 24.544 µM -1.29444053685641 0.0919035372951729 no 3006 0.0977566481198614 4383 728868 YDL195W SEC31
SGTC_99 0109-0120 622.8 µM -1.2965134380093 0.091558939079083 no 3007 0.0973993267030515 4355 759414
SGTC_546 peri-Naphthalide 147 µM -1.29872472830549 0.0911923916487005 no 3008 0.0970192072960926 4301 223824 A penicillin ester.
SGTC_3146 9095609 49.47 µM -1.30140948645119 0.0907488253010286 no 3009 0.0965591641140746 4412 17173999
SGTC_2843 9000894 45.46 µM -1.30622375780335 0.0899574413462002 no 3010 0.095738237897917 4337 2242070
SGTC_2808 7946468 45.46 µM -1.30652599460365 0.0899079304103425 no 3011 0.0956868725064475 4348 2970879
SGTC_2356 9061756 188.97 µM -1.30805915329018 0.0896570878444698 no 3012 0.09542662321458 4405 20104043
SGTC_22 0964-0034 14.468 µM -1.30921996188643 0.0894675124844305 no 3013 0.0952299261370163 4379 138402
SGTC_2026 5148700 152 µM -1.31328028092541 0.0888067539361857 no 3014 0.0945442603273907 4356 79838
SGTC_367 0335-0881 7.1 µM -1.31420383435651 0.0886569674376745 no 3015 0.0943888092525701 4322 23828853
SGTC_1249 0481-0015 10.2 µM -1.31462980339739 0.0885879450979161 no 3016 0.0943171743547416 4301 4227577
SGTC_478 N-arachidonylglycine 10 µM -1.31542731122245 0.0884588277189313 no 3017 0.0941831658750215 4372 5283389
SGTC_1505 k297-0037 20.6 µM -1.31696411388974 0.0882104132192399 no 3018 0.0939253268879302 4365 4089396
SGTC_2188 6126565 140.678 µM -1.3188921267438 0.087899497907406 no 3019 0.0936025893367265 4280 874518
SGTC_2940 9060638 45.86 µM -1.32031092232048 0.0876712225558188 no 3020 0.093365615191705 4370 4027022
SGTC_182 3448-4371 550.524 µM -1.32047359613258 0.0876450776446503 no 3021 0.0933384729662111 4271 3491403
SGTC_1064 honokiol 6.76 µM -1.3209509948156 0.0875683837857801 no 3022 0.0932588523588812 4406 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2915 7971052 15.16 µM -1.32097954717895 0.0875637984505851 no 3023 0.0932540919833641 4294 5741558
SGTC_2354 9060492 162 µM -1.32168678898406 0.0874502769122304 no 3024 0.09313623481721 4404 6471895
SGTC_1904 st060225 78 µM -1.32353913972435 0.0871534711076572 no 3025 0.092828074601359 4340 66595
SGTC_2243 6634756 200 µM -1.3243413526497 0.0870251646407345 no 3026 0.0926948513017462 4433 885676
SGTC_3093 9117344 49.47 µM -1.32717316346195 0.0865733709386196 no 3027 0.0922257038029834 4393 24824913
SGTC_1681 tripelennamine 100 µM -1.32860240421016 0.0863460133650624 no 3028 0.0919895892253931 4298 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_815 1582-0027 36.9 µM -1.32868504932204 0.0863328801989758 no 3029 0.091975949724356 4403 3128206
SGTC_1705 st027868 56.3335 µM -1.33391728340034 0.0855044616446125 no 3030 0.0911154833122403 4323 292948
SGTC_1276 0871-0068 94.2 µM -1.33435736252955 0.0854350563566056 no 3031 0.0910433832559742 4414 3414906
SGTC_1827 berberine 7.24 µM -1.33441037185928 0.0854266990542777 no 3032 0.0910347013659894 4293 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2751 anetholtrithion 17.25 µM -1.3357173332282 0.0852208407990413 no 3033 0.0908208408659648 4366 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1429 4049-0205 9.46 µM -1.3366108742411 0.0850803140680248 no 3034 0.0906748438078188 4442 22774478
SGTC_3351 9150312 21.596 µM -1.34108146300359 0.0843798340256192 no 3035 0.0899470025381302 4298 4904905
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.34262669606072 0.084138726267019 no 3036 0.0896964407911559 4420 23847180
SGTC_2285 7945142 200 µM -1.34556327902379 0.0836819475498576 no 3037 0.0892217004445846 4422 2970608
SGTC_826 1683-5028 118 µM -1.3497483534287 0.0830341917899783 no 3038 0.0885483582077647 4435 722377
SGTC_777 1315-0167 517 µM -1.35570638693327 0.0821185376242147 no 3039 0.0875963032308885 4434 4221767
SGTC_1753 st043925 64 µM -1.35583225181916 0.082099276584541 no 3040 0.0875762735495357 4429 670181
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.35702861842404 0.0819163670974579 no 3041 0.0873860587100324 4427 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3083 9117465 49.47 µM -1.35967622734088 0.081512672845187 no 3042 0.0869662020877858 4373 16420915
SGTC_1626 st003712 1.76 µM -1.36406849159669 0.0808462738169944 no 3043 0.086273005149534 4434 24207035
SGTC_630 4356-0227 183 µM -1.36464160128861 0.0807596252425247 no 3044 0.0861828613412414 4359 779312
SGTC_891 0929-0073 133 µM -1.36856708807104 0.0801680141908334 no 3045 0.0855673188676264 4440 5603632
SGTC_2608 thymoquinone 42.66 µM -1.37118050191232 0.0797759662285432 no 3046 0.0851593473998835 4375 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1272 0839-0021 27 µM -1.37516141912624 0.0791815633696061 no 3047 0.0845407031836191 4449 5027250
SGTC_1659 st012954 42.1 µM -1.37735725460735 0.0788551346892336 no 3048 0.08420091084999 4392 24207262
SGTC_2493 resveratrol 26.09 µM -1.37813816304505 0.0787392924275924 no 3049 0.0840803173939976 4351 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_357 1325-0123 420 µM -1.37915252709837 0.0785890112713629 no 3050 0.0839238657218178 4436 1098503
SGTC_2476 5806916 10.51 µM -1.38102824346478 0.0783116909550441 no 3051 0.0836351383793367 4329 2870194
SGTC_3082 9117008 49.47 µM -1.38582508173168 0.0776058655377847 no 3052 0.082900160823092 4452 41448529
SGTC_211 3455-0679 143.504 µM -1.387483077001 0.0773630282329026 no 3053 0.0826472539609732 4421 748649
SGTC_1548 st061468 90.8 µM -1.38825406670073 0.0772503024680026 no 3054 0.0825298469156096 4459 390799
SGTC_493 zm226600 134 µM -1.39010398747248 0.0769803360444019 no 3055 0.0822486513175162 4438 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3058 9093861 49.47 µM -1.39012771184302 0.0769768785141717 no 3056 0.0822450498073727 4439 17217477
SGTC_2813 7971799 71.43 µM -1.39335341522814 0.0765078708177401 no 3057 0.0817564727097424 4434 2234054
SGTC_443 clozapine 122 µM -1.39345822575141 0.0764926682229728 no 3058 0.0817406344936968 4418 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_567 1080-0542 68.4 µM -1.39535719522416 0.0762176236549658 no 3059 0.0814540762491318 4319 5950415
SGTC_1562 morin hydrate 59.1 µM -1.39616489882889 0.0761008652072786 no 3060 0.0813324220961081 4441 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_880 0833-0487 87.2 µM -1.4016954966229 0.0753050389622303 no 3061 0.0805030980005951 4434 76075
SGTC_417 st075190 100 µM -1.40196732685219 0.0752660881021909 no 3062 0.0804625018385712 4424 222757
SGTC_3315 9136395 68.55 µM -1.40267533100149 0.0751647094890945 no 3063 0.0803568384051205 4420 16876844
SGTC_32 0928-0142 34.1 µM -1.40270050228911 0.0751611071477966 no 3064 0.0803530837413645 4424 2244242
SGTC_2820 7989630 71.43 µM -1.40881519960033 0.0742899080462671 no 3065 0.0794449097621626 4468 2984098
SGTC_3128 9127691 49.47 µM -1.40989208233985 0.0741372796918314 no 3066 0.0792857754675285 4457 41316314
SGTC_2643 anethole 100 µM -1.41963050355037 0.072767895638561 no 3067 0.0778576400672352 4443 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1371 2421-0008 32.7 µM -1.42172256489952 0.0724762601818327 no 3068 0.0775534034041871 4442 2827552
SGTC_585 0kpi-0023 191 µM -1.42236519081992 0.0723868574800557 no 3069 0.0774601314120133 4382 64601
SGTC_3039 9090270 49.47 µM -1.42520303979492 0.0719930635376506 no 3070 0.0770492589524471 4462 17173750
SGTC_2116 5511452 16.8835 µM -1.42875071232013 0.071503083658217 no 3071 0.0765379481912636 4460 870744
SGTC_534 k292-0788 63.4 µM -1.43130268159024 0.0711522087938995 no 3072 0.0761717428652073 4493 4146317
SGTC_1462 k081-0014 26.5 µM -1.43391248343239 0.0707947513136569 no 3073 0.0757986195019335 3891 3270634
SGTC_3327 9140648 26.9345 µM -1.43395560850585 0.070788856198942 no 3074 0.0757924656228915 4477 8029710
SGTC_1435 4092-0789 56.7 µM -1.43464629704818 0.070694491787903 no 3075 0.0756939573174618 4457 2248285
SGTC_924 2046-0044 21.3 µM -1.43606809887129 0.070500544331906 no 3076 0.0754914822715299 4436 3623589
SGTC_2789 5281112 71.43 µM -1.43653058164327 0.0704375454711739 no 3077 0.0754257103590408 4454 765948
SGTC_1970 st070122 35.8 µM -1.44056682573858 0.0698895687757856 no 3078 0.0748535491043566 4470 102928
SGTC_163 TUB2.036 7.546 µM -1.44155630514631 0.0697557350890428 no 3079 0.0747137912592672 4398 15992207 YJR013W GPI14
SGTC_2649 anisomycin 9.56 µM -1.44359003025219 0.069481279708742 no 3080 0.0744271654974772 4508 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1105 epirubicin 18.1 µM -1.44476253298768 0.0693234264093106 no 3081 0.074262299205103 4504 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_902 1120-0002 2.07 µM -1.44528008692124 0.0692538363959945 no 3082 0.0741896144312182 4448 3280475
SGTC_1426 4048-4480 71.7 µM -1.44568997101217 0.0691987618085183 no 3083 0.0741320892719484 4471 14224343
SGTC_1974 st069448 26.9 µM -1.44615886824891 0.0691357992363033 no 3084 0.0740663237054308 4461 6323587 YNR016C ACC1
SGTC_1847 st056231 15 µM -1.4507423561932 0.0685226604153631 no 3085 0.07342580816304 4455 5393180
SGTC_1244 0416-0015 52.5 µM -1.45287846538756 0.068238347301226 no 3086 0.073128750502649 4441 96201
SGTC_2972 9093619 59.92 µM -1.45550337389161 0.0678902234833882 no 3087 0.0727649784326272 4421 25236256
SGTC_307 1501-1223 22.3 µM -1.45584502890053 0.067845013151433 no 3088 0.0727177323726366 4502 2830329
SGTC_1888 azatryptophan 97.5 µM -1.4582688496011 0.0675249424997148 no 3089 0.0723832264264918 4503 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_933 2914-0560 114 µM -1.4585941105204 0.0674820800515858 no 3090 0.0723384277780794 4484 463887
SGTC_3255 9139072 49.47 µM -1.4624504692581 0.066975495384601 no 3091 0.0718089039451205 4467 17646060
SGTC_374 0880-0231 82.3 µM -1.46343489419111 0.0668466503794796 no 3092 0.0716742081974328 4342 6833587
SGTC_293 4049-0273 38.5 µM -1.46736065527328 0.0663347394113299 no 3093 0.071138985775623 4344 1380311
SGTC_1792 st045773 43.6 µM -1.47206275009986 0.0657255977188802 no 3094 0.0705019666452192 4458 2919270
SGTC_908 3448-7491 47.7 µM -1.47251463759762 0.0656672862410982 no 3095 0.0704409786083639 4472 1203031
SGTC_2987 9018338 71.43 µM -1.47687386619893 0.0651068299830426 no 3096 0.0698547257338226 4497 5055682
SGTC_2694 st077685 81.9 µM -1.47869408433441 0.0648739101368246 no 3097 0.0696110470424174 4407 2838096
SGTC_306 1672-3436 11.6 µM -1.47937699452996 0.0647866902475351 no 3098 0.069519792589345 4495 6797378
SGTC_975 1335-0046 28.5 µM -1.48209006082517 0.0644410821484831 no 3099 0.0691581665305963 4486 16486740
SGTC_1332 1480-0653 17.5 µM -1.48371923800139 0.0642342363132259 no 3100 0.0689417101901715 4485 5749438
SGTC_588 3970-1144 52.9 µM -1.4865660681921 0.0638740323092846 no 3101 0.0685647276158548 4386 1888707
SGTC_2165 5727197 32.143 µM -1.48876593478481 0.0635967649304387 no 3102 0.0682745077937035 4540 1361712
SGTC_3284 9108171 64.8615 µM -1.49055241211685 0.0633722902468392 no 3103 0.0680395230970754 4467 8687505
SGTC_841 0251-0215 91.2 µM -1.49675088370383 0.0625982190796197 no 3104 0.0672290453887227 4535 3888614
SGTC_2336 9001819 198.65 µM -1.50374276868011 0.0617339331464649 no 3105 0.0663238061950741 4507 2989602
SGTC_2094 5332512 191.667 µM -1.51839972998003 0.0599524022931716 no 3106 0.0644568298578426 4529 755774
SGTC_1221 2958-7315 257 µM -1.51900691901353 0.0598794772265918 no 3107 0.0643803771953699 4521 4562705
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.51977294886782 0.0597875740857479 no 3108 0.0642840250408153 4378 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.52044671651473 0.0597068313206116 no 3109 0.0641993704065039 4453 6708630 An antioxidant.
SGTC_2225 6654152 15.4 µM -1.52147725011348 0.0595834998486159 no 3110 0.0640700580492429 4450 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_397 arbidol 50 µM -1.52429520212904 0.0592472742578388 no 3111 0.0637174925780458 4525 131410 A RNA synthesis inhibitor.
SGTC_2899 9053889 58.44 µM -1.5270993741065 0.0589141715456491 no 3112 0.0633681512807651 4500 6470052
SGTC_2093 5331342 194.4 µM -1.52797752608966 0.0588101600849885 no 3113 0.0632590589787278 4535 33839
SGTC_2371 9071574 200 µM -1.53422376290443 0.0580744860945257 no 3114 0.0624873067802605 4520 45596039
SGTC_2619 obliquin 87.91 µM -1.53422862004821 0.0580739168531797 no 3115 0.0624867095263648 4489 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2859 9028643 45.46 µM -1.53523024404789 0.0579566234508885 no 3116 0.0623636408837129 4342 17151580
SGTC_1865 st057639 52.2 µM -1.54265939864775 0.0570924484567663 no 3117 0.0614567189448325 4520 688818
SGTC_1637 st007924 17.4 µM -1.54347195253051 0.0569985491145141 no 3118 0.0613581537806784 4426 683336
SGTC_3177 9107506 49.47 µM -1.55137080348737 0.0560920758978885 no 3119 0.0604064239427251 4488 8897194
SGTC_721 1187-1332 279 µM -1.55271053640085 0.0559394618320073 no 3120 0.0602461520013068 4527 25730
SGTC_2273 7815444 169.05 µM -1.55378933425308 0.0558168100944372 no 3121 0.0601173377499313 4458 2824616
SGTC_1453 4237-0541 195 µM -1.555103439484 0.0556676923251039 no 3122 0.0599607179731445 4522 739892
SGTC_3002 9075603 71.4286 µM -1.55589576516385 0.0555779354076689 no 3123 0.0598664402887583 4476 20105405
SGTC_2743 auranofin 4.32 µM -1.55681291904627 0.055474180287285 no 3124 0.0597574545140515 4592 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2321 7390090 138.78 µM -1.55795023478503 0.0553457313143811 no 3125 0.0596225227761533 4523 649046
SGTC_550 4123-0385 25.7 µM -1.56040825061823 0.0550689242313916 no 3126 0.0593317181647387 4548 5731123
SGTC_2159 5658611 73.75 µM -1.56435195051772 0.0546270948495673 no 3127 0.0588674690776831 4513 793844
SGTC_2348 9022543 33.42 µM -1.56611665407384 0.0544302975797469 no 3128 0.0586606549527301 4537 3162678 YDL140C RPO21
SGTC_2645 abamectin 100 µM -1.5667280586947 0.0543622455455994 no 3129 0.0585891346790552 4477 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1111 tnp00062 510.699 nM -1.57423620368076 0.0535320331715721 no 3130 0.0577164262110358 4537 676306
SGTC_2397 5161689 200 µM -1.57685089244748 0.0532452838439693 no 3131 0.0574149191293475 4543 2259942
SGTC_739 1486-1183 203 µM -1.58348060656855 0.0525236685245978 no 3132 0.0566559817472067 4527 4346692
SGTC_877 0771-0151 33.1 µM -1.58369077782566 0.0525009198806784 no 3133 0.0566320522388718 4538 6166523
SGTC_1395 3486-0190 4.35 µM -1.58463592529113 0.0523987150878164 no 3134 0.0565245388137954 4517 6748079
SGTC_1734 st037168 69.4 µM -1.58767933023927 0.0520706853126817 no 3135 0.0561794346629058 4540 708907
SGTC_35 0133-0054 64.071 µM -1.58845862741835 0.0519869525773512 no 3136 0.0560913346723636 4498 99677
SGTC_1871 st057448 67.3 µM -1.59049047897301 0.0517691403255167 no 3137 0.0558621450275883 4533 691747
SGTC_907 3448-6986 75.5 µM -1.59157838697344 0.0516528162954778 no 3138 0.0557397347756454 4547 590582
SGTC_85 0868-0259 160.055 µM -1.59202197522785 0.0516054455167803 no 3139 0.0556898834869101 4487 83173
SGTC_1953 st076800 12.1 µM -1.59235828998419 0.051569553498817 no 3140 0.0556521112537152 4505 297591
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.59354174961656 0.0514434106934866 no 3141 0.0555193551028278 4556 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1525 8-methoxypsoralen 92.5 µM -1.59635224658324 0.0511448282598411 no 3142 0.0552050856918779 4563 4114 Related to psoralen; DNA damaging agent.
SGTC_1168 k815-0004 80.5 µM -1.60163956898567 0.0505868508362339 no 3143 0.0546176677527292 4544 642433
SGTC_2373 9071805 200 µM -1.60164009938412 0.0505867951068798 no 3144 0.0546176090747269 4554 10149009
SGTC_491 tetrandrine 80.3 µM -1.60275461185422 0.0504698004399996 no 3145 0.054494420574252 4555 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3238 9133470 49.47 µM -1.61373011578364 0.0493291403845736 no 3146 0.0532929893258419 4552 3534688
SGTC_1907 st060210 83.7 µM -1.61377123284599 0.049324906204441 no 3147 0.0532885282541575 4544 688793
SGTC_2742 clothiapine 36.27 µM -1.61411636031253 0.0492893768783027 no 3148 0.0532510946801477 4597 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2767 sibutramine 71.45 µM -1.61462530403305 0.0492370206917102 no 3149 0.0531959311342915 4541 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1975 st070967 30.8 µM -1.61553305087476 0.049143748981642 no 3150 0.0530976544629124 4553 261391
SGTC_2692 st077426 47.7 µM -1.61833136264501 0.0488571080068697 no 3151 0.0527956026139182 4540 25238571
SGTC_332 4112-0506 40.9 µM -1.61892208454871 0.0487967693917929 no 3152 0.0527320142427903 4548 2790355
SGTC_1354 1498-1681 81 µM -1.62133869974572 0.0485505469110421 no 3153 0.0524725098112835 4582 5754243
SGTC_527 4476-4215 268 µM -1.62434330479942 0.0482458021636508 no 3154 0.0521512799227163 4543 4418754
SGTC_564 3555-0129 330 µM -1.62437893391919 0.0482421976505496 no 3155 0.0521474801159351 4461 563260
SGTC_1467 k284-1082 293 µM -1.62470912222085 0.0482088035362907 no 3156 0.0521122763547939 4532 3334705
SGTC_731 3966-0296 387 µM -1.62538375831763 0.0481406306495537 no 3157 0.0520404072151067 4566 660956
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.62870571380519 0.0478060669323436 no 3158 0.0516876663026364 4530 16623 A steroid.
SGTC_1560 lithocholic acid 53.1 µM -1.62889897784271 0.047786660201723 no 3159 0.0516672032642652 4508 9903 A bile acid which acts as a detergent.
SGTC_3213 9129884 49.47 µM -1.62889956078996 0.04778660167425 no 3160 0.0516671415508245 4527 17190742
SGTC_2616 abietic acid 100 µM -1.63664269368572 0.0470142463729877 no 3161 0.0508525746978694 4586 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1232 0279-0259 161 µM -1.63828123693384 0.046852096569105 no 3162 0.0506815199490675 4549 1560000
SGTC_663 1486-0733 13.9 µM -1.64106288486565 0.0465778528374091 no 3163 0.0503921810709493 4576 722445 YPR165W RHO1
SGTC_2413 inermin 26.06 µM -1.64471346978242 0.0462198966322898 no 3164 0.0500144568657003 4585 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_278 4092-0821 23.9 µM -1.65498010130546 0.0452250391979985 no 3165 0.0489642671811936 4554 877900
SGTC_2429 5902844 64.44 µM -1.65658321406803 0.0450712610402501 no 3166 0.0488018841882213 4557 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1138 3761-0006 1.03 µM -1.6605695099879 0.0446907004494906 no 3167 0.0483999683980273 4597 12061087
SGTC_894 0960-0238 55.9 µM -1.66134175344709 0.0446172765899731 no 3168 0.0483224143903286 4572 6741907 YDL195W SEC31
SGTC_1656 st012921 11 µM -1.66349956225359 0.0444126300158919 no 3169 0.0481062392029849 4501 6732821
SGTC_723 4182-0001 115 µM -1.66590047461472 0.0441858171852966 no 3170 0.0478666195442316 4573 744821 YLR208W SEC13
SGTC_3032 9089427 49.47 µM -1.6681900968892 0.0439703886008679 no 3171 0.0476389980809795 4542 17173707
SGTC_2126 5251174 33.877 µM -1.67057492492796 0.0437469036154889 no 3172 0.0474028343816152 4554 790722
SGTC_3262 9137218 49.47 µM -1.67090875215583 0.0437156935294643 no 3173 0.0473698512618968 4580 17650664
SGTC_1261 0712-0010 12.7 µM -1.68090561421361 0.0427893647214058 no 3174 0.0463906246551655 4565 2840123
SGTC_2485 5633444 17.78 µM -1.69375137998958 0.0416224122882638 no 3175 0.0451562682766685 4548 5724239
SGTC_52 0329-0193 875 nM -1.6952764176537 0.0414856012950009 no 3176 0.0450114981200495 4608 3739292
SGTC_2909 7941780 10.49 µM -1.69898216709871 0.0411546769884369 no 3177 0.0446612718533944 4538 1243215
SGTC_3251 9135047 49.47 µM -1.70277504700846 0.0408181916005109 no 3178 0.0443050871366034 4627 17682963
SGTC_3048 9093155 49.47 µM -1.70312115257515 0.0407875982985638 no 3179 0.0442726990973579 4584 25236002
SGTC_3354 9151612 71.43 µM -1.7065362798465 0.0404867214786569 no 3180 0.0439541387416001 4565 27261949
SGTC_150 3970-0969 77.2 µM -1.71147224180832 0.0400550440315566 no 3181 0.043496985573767 4598 6615640
SGTC_2740 felodipine 17.08 µM -1.71405777178973 0.0398304219406689 no 3182 0.0432590581205325 4654 3333 L-type calcium channel blocker
SGTC_3071 9117417 49.47 µM -1.71597734068158 0.0396643194787116 no 3183 0.043083094889248 4551 45595590 YGL055W OLE1
SGTC_1757 st041620 31.8375 µM -1.71642490525278 0.0396256722979064 no 3184 0.043042150730513 4589 5289815
SGTC_1833 st055984 71 µM -1.7178739561481 0.0395007568432506 no 3185 0.042909804080107 4628 676288
SGTC_2275 7947463 200 µM -1.71790698073253 0.0394979136959559 no 3186 0.0429067916716729 4557 1225414
SGTC_1981 st071826 47 µM -1.71939202102991 0.0393702357865093 no 3187 0.0427715070618676 4624 11838600
SGTC_2749 bexarotene 57.39 µM -1.71952779259516 0.0393585794558073 no 3188 0.0427591557276759 4594 82146 An retinoic acid receptor inhibitor.
SGTC_748 act1.228 77.9 µM -1.7208750185533 0.0392430688186229 no 3189 0.0426367528244946 4578 4421505 YNR035C ARC35
SGTC_2286 7945697 125 µM -1.72091841403003 0.0392393526984854 no 3190 0.0426328148207707 4559 1245733
SGTC_873 0591-4978 488 µM -1.72243205273523 0.039109913149341 no 3191 0.0424956407622928 4603 3305145
SGTC_1749 st037932 54.2 µM -1.72448407288127 0.0389349888873207 no 3192 0.0423102458910861 4574 594497
SGTC_1176 0848-0131 83.3 µM -1.73294310216087 0.0382206143770401 no 3193 0.0415528911446836 4647 6769040
SGTC_248 streptozotocin 5.23457 mM -1.73711030701539 0.037872639246332 no 3194 0.0411838512034746 4639 5300 DNA alkylating agent.
SGTC_1914 st062367 72.6 µM -1.7416201770826 0.0374989677998637 no 3195 0.0407874641733547 4572 978205
SGTC_2081 5214970 32.255 µM -1.74967075030933 0.0368394135587102 no 3196 0.0400875718292196 4558 2063512
SGTC_1410 3909-8106 77.9 µM -1.75258754730265 0.0366028044857346 no 3197 0.0398364151600081 4644 1039210
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.75680682874841 0.0362627398264171 no 3198 0.0394753703720242 4583 115019
SGTC_1036 k216-0215 33.5 µM -1.75855720718248 0.0361224243571406 no 3199 0.0393263733995199 4566 622330
SGTC_2032 5185112 25.99 µM -1.7589877979366 0.0360879751619239 no 3200 0.0392897905609945 4494 5718189
SGTC_1162 k048-0130 20.1 µM -1.76358891997667 0.0357215418376003 no 3201 0.0389006072559313 4614 6797406
SGTC_1794 st048918 76.9 µM -1.76622554682915 0.0355129388656049 no 3202 0.0386790083583789 4605 672303
SGTC_406 estrone 100 µM -1.7701875182087 0.0352013570354183 no 3203 0.0383479539656576 4604 5870 A steroid.
SGTC_1007 4101-0031 70 µM -1.77468935292939 0.0348500442721506 no 3204 0.0379745971474257 4611 1146276
SGTC_1702 st027038 51 µM -1.77491197390819 0.0348327464059862 no 3205 0.0379562114425709 4649 5521182
SGTC_2171 5739187 198.077 µM -1.77914147846171 0.0345054467478518 no 3206 0.0376082849529569 4584 2262761
SGTC_2884 9058502 51.95 µM -1.78845068030267 0.0337939514851624 no 3207 0.0368516629794208 4605 6471554
SGTC_1531 st059297 52.4 µM -1.79212723837097 0.0335163000642865 no 3208 0.0365562933019576 4636 7566702
SGTC_9 0092-0002 10.449 µM -1.79392704830304 0.0333810657241241 no 3209 0.0364124067806555 4624 759368
SGTC_2929 9013348 24.6 µM -1.79423061191516 0.0333583008661572 no 3210 0.0363881840073905 4592 2995952
SGTC_2912 7964298 10.93 µM -1.79687904689813 0.0331602311215454 no 3211 0.0361774118523429 4607 2975850
SGTC_1060 3448-7350 82 µM -1.79909842428646 0.0329949965506687 no 3212 0.0360015564362052 4579 570178
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.8005143620341 0.0328899337179156 no 3213 0.0358897289438368 4575 17037758
SGTC_1140 3229-1848 2.98 µM -1.80796704102687 0.0323414794889111 no 3214 0.0353058151990408 4626 2849525
SGTC_2770 toltrazuril 17.5 µM -1.81091963961331 0.0321262906753435 no 3215 0.0350766459910381 4562 68591 Kills coccidiodes.
SGTC_2895 9054447 58.44 µM -1.81118975654235 0.0321066633933781 no 3216 0.0350557416498495 4686 2697450
SGTC_3343 9148379 18.9835 µM -1.81728726578672 0.031666232699295 no 3217 0.0345865693983102 4645 1955036
SGTC_473 2-arachidonoylglycerol 10 µM -1.8206136477999 0.0314280763082837 no 3218 0.0343328033789642 4503 5282280 An endocannabinoid.
SGTC_2306 7482397 179.52 µM -1.82080487737296 0.031414430127448 no 3219 0.0343182613207069 4610 891448
SGTC_1730 st033808 45.1 µM -1.82194197918204 0.0313333874508181 no 3220 0.0342318948922637 4563 1045166
SGTC_2642 cholecalciferol 100 µM -1.82219875364955 0.0313151107597935 no 3221 0.0342124168186209 4638 9821465 A vitamin D precursor, similar to steriods.
SGTC_1041 0206-0046 107 µM -1.82251854121241 0.0312923612506769 no 3222 0.0341881715166357 4641 50494
SGTC_1523 st012844 44.7 µM -1.82467844586937 0.0311390644963108 no 3223 0.0340247838752554 4651 4274103
SGTC_37 0566-0070 1.56 µM -1.84147342421795 0.0299681364883882 no 3224 0.0327761058058643 4569 1626686
SGTC_2406 ethylparaben 405.7 µM -1.8444765775154 0.0297626574607605 no 3225 0.0325568581246371 4589 8434 A possible steroid mimic.
SGTC_1855 st056195 39.6 µM -1.85115810082149 0.0293096915159716 no 3226 0.0320734057644931 4586 4028379
SGTC_2177 5811945 192 µM -1.85402492749482 0.0291171012502817 no 3227 0.0318677968998162 4625 5343475
SGTC_2086 5274770 176.623 µM -1.85671744723354 0.0289371793141883 no 3228 0.0316756819628171 4667 689278
SGTC_2827 7993847 71.43 µM -1.86122048204365 0.0286383389404506 no 3229 0.0313565235451601 4669 2985692
SGTC_2696 st077691 74.316 µM -1.8664457588987 0.0282947892801777 no 3230 0.0309895130691097 4634 757133
SGTC_2221 6807166 181.081 µM -1.8730758353504 0.0278638213791135 no 3231 0.0305289568488632 4653 674925
SGTC_280 3448-3607 3.04 µM -1.87604319176091 0.0276727164051863 no 3232 0.0303246746343795 4624 626179
SGTC_2516 gossypol 71.55 µM -1.88556200170686 0.0270670400158209 no 3233 0.0296770009755036 4660 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2145 5634607 200 µM -1.88684685267304 0.026986139501913 no 3234 0.0295904636280575 4665 308662
SGTC_1933 st074711 15.9 µM -1.89461862682943 0.0265010819844803 no 3235 0.0290714726229719 4658 17250958
SGTC_60 0986-0278 202 µM -1.89970525992516 0.0261875725095731 no 3236 0.02873590484204 4609 3110598
SGTC_702 1488-0190 94 µM -1.90211155367117 0.0260403470358499 no 3237 0.0285782861633781 4683 949357
SGTC_1411 3909-8223 150 µM -1.90350796689552 0.0259552274832696 no 3238 0.0284871475625963 4702 X1411
SGTC_2747 doxorubicin 7.63 µM -1.90852520129205 0.025651315960016 no 3239 0.0281616845694805 4731 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3077 9117319 49.47 µM -1.90928782829265 0.0256053828190278 no 3240 0.0281124858034484 4616 17154678
SGTC_382 3229-0966 23.2 µM -1.91440823238417 0.0252987602299649 no 3241 0.0277840072462571 4680 5722370
SGTC_2520 obtusaquinone 4.71 µM -1.91515529892185 0.0252542822228969 no 3242 0.0277363506439862 4668 5967872
SGTC_2054 5233173 129 µM -1.95293165763226 0.0230891150106185 no 3243 0.0254138469344773 4664 6889
SGTC_1874 staurosporine 7.6 µM -1.9562241196018 0.0229080441728469 no 3244 0.025219379199502 4664 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1487 3970-0795 2.82 µM -1.95877791013026 0.0227684221053737 no 3245 0.025069400820923 4699 3765103
SGTC_2879 9041815 71.43 µM -1.95973378724725 0.0227163466993626 no 3246 0.0250134569322381 4704 4942971
SGTC_1414 3917-0015 5.4 µM -1.96133365121005 0.022629412030913 no 3247 0.0249200571121186 4692 6618702
SGTC_2717 st081029 62.2815 µM -1.96309045319903 0.0225342727803553 no 3248 0.0248178323286668 4661 5292846
SGTC_3246 9135460 32.98 µM -1.97603799058352 0.021843451564737 no 3249 0.0240752372971469 4681 41446951
SGTC_282 k297-0036 65.7 µM -1.97616527471315 0.0218367500596686 no 3250 0.0240680307173731 4669 5061378
SGTC_1372 2752-0194 270 µM -1.97935545817833 0.0216693532992154 no 3251 0.0238879998404538 4613 823334
SGTC_1033 k072-0102 21.3 µM -1.98877911424015 0.0211811898732763 no 3252 0.0233627945352742 4643 5965931
SGTC_2219 9098279 200 µM -1.99012727772003 0.0211121188778112 no 3253 0.0232884583208362 4652 902349
SGTC_1237 0330-0133 46.1 µM -1.99056601471676 0.0210896820286676 no 3254 0.0232643098335047 4648 X1237 YHR072W ERG7
SGTC_2654 protoveratrine a 100 µM -1.99922147618016 0.0206511530059262 no 3255 0.0227921979382949 4710 5702278 A heart drug and vasodilator.
SGTC_2055 5235184 200 µM -1.99958245767395 0.0206330329090625 no 3256 0.0227726848767595 4668 2836034
SGTC_3062 9077494 49.47 µM -2.00237054077377 0.0204935333810532 no 3257 0.0226224472014444 4627 16459633
SGTC_1622 st003707 19.4 µM -2.00701611432024 0.0202628710092165 no 3258 0.0223739735940249 4685 10140899
SGTC_2885 9057732 51.95 µM -2.01257586156778 0.0199897149224097 no 3259 0.022079634244502 4684 6471414
SGTC_1758 st042942 75.2445 µM -2.01641962389228 0.0198026987850024 no 3260 0.0218780575937867 4662 669317
SGTC_1489 4065-0444 182 µM -2.01766520325768 0.0197424152810053 no 3261 0.0218130705664546 4701 2877968
SGTC_905 2-aminofluorene 215 µM -2.02140080013577 0.0195625533975422 no 3262 0.0216191459757432 4707 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1755 st041960 45.185 µM -2.02354484530707 0.0194599516686546 no 3263 0.0215085024570342 4701 2257073
SGTC_3215 9129942 49.47 µM -2.02788085658796 0.0192538515016487 no 3264 0.0212862046923418 4664 17682944
SGTC_1766 st045414 44.774 µM -2.02982575802265 0.0191620104834895 no 3265 0.0211871268660774 4695 253960
SGTC_1263 0774-1208 64.8 µM -2.04170545852201 0.0186090817651432 no 3266 0.020590378496853 4658 906585
SGTC_2181 6316240 54.2555 µM -2.04202619636104 0.0185943436451537 no 3267 0.0205744664332242 4702 12779990
SGTC_50 0929-0078 56.389 µM -2.04599898585394 0.0184126135997129 no 3268 0.0203782352264509 4584 1377751
SGTC_780 0109-0199 192 µM -2.04885082424575 0.0182830946506307 no 3269 0.0202383520958418 4699 610414
SGTC_3214 9129694 49.47 µM -2.04946356929447 0.0182553677906201 no 3270 0.0202084033379719 4674 17158655
SGTC_1141 3253-0389 52.6 µM -2.05634389412184 0.0179464834991774 no 3271 0.0198746900903007 4692 5402031
SGTC_2834 9001755 58.44 µM -2.07101426437185 0.0173027307436633 no 3272 0.0191787315238488 4568 2989575
SGTC_2544 sphondin 68.51 µM -2.09642334643615 0.0162343880756783 no 3273 0.0180223265836339 4661 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3270 9137563 49.47 µM -2.101569793052 0.0160250245142789 no 3274 0.0177954891286944 4707 17015724
SGTC_3250 9135583 49.47 µM -2.10303573799836 0.0159658132799451 no 3275 0.017731322797165 4713 7699353
SGTC_2000 st075254 36.4 µM -2.12050791770706 0.0152744080200287 no 3276 0.0169816172627626 4658 17234175
SGTC_1735 st034310 56.75 µM -2.12553395413355 0.015080345066474 no 3277 0.0167710419905741 4696 871153
SGTC_485 niflumic acid 177 µM -2.13398467469607 0.0147588252724721 no 3278 0.0164220176687416 4728 4488 A COX2 inhibitor.
SGTC_3207 9114163 49.47 µM -2.15915883643355 0.013835749946067 no 3279 0.0154189231734216 4682 849233
SGTC_477 mead ethanolamide 10 µM -2.16227319412728 0.0137250902611603 no 3280 0.0152985623236224 4745 16061185
SGTC_3065 9113888 49.47 µM -2.16242926183537 0.0137195649941175 no 3281 0.0152925520516957 4717 16648368
SGTC_1552 6-methylflavone 10.6 µM -2.17196056016406 0.0133857455590689 no 3282 0.0149293189462645 4705 689013
SGTC_2190 6049624 200 µM -2.17651978833608 0.0132285610514104 no 3283 0.0147582078288266 4676 2265554
SGTC_404 fumagillin 50 µM -2.17738347895013 0.0131989646889321 no 3284 0.0147259836523046 4722 12015870 A methionine aminopeptidase binder.
SGTC_775 4577-0580 57.3 µM -2.17835558031127 0.0131657218324117 no 3285 0.0146897871008661 4711 2006902
SGTC_39 0986-0283 58.349 µM -2.18493113116182 0.0129427525152107 no 3286 0.014446948262383 4723 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_703 3875-0075 71.8 µM -2.18957632321824 0.0127872142865244 no 3287 0.0142774888517732 4746 2850814
SGTC_2056 5235370 200 µM -2.20072228802819 0.0124205859966376 no 3288 0.0138778449890316 4661 5511916
SGTC_2035 5154463 94.595 µM -2.2113979059798 0.012078000106653 no 3289 0.0135041473656486 4730 2769623
SGTC_3015 9080845 49.47 µM -2.21184996102538 0.0120636760271685 no 3290 0.0134885168483096 4736 5296973
SGTC_1651 st011928 86.1 µM -2.22040533847403 0.0117953492161853 no 3291 0.0131956324984725 4732 720198
SGTC_728 3030-5151 22.5 µM -2.24246523872947 0.0111272396264657 no 3292 0.0124656597534668 4750 3125388
SGTC_3193 9111931 49.47 µM -2.25318056277662 0.010814761090109 no 3293 0.0121238832214373 4718 17087244
SGTC_1494 4358-1428 177 µM -2.27345303482594 0.0102444265427874 no 3294 0.0114994466350893 4763 1564571
SGTC_974 1326-0144 138 µM -2.27476806086635 0.0102083534508219 no 3295 0.0114599235820677 4742 5411856
SGTC_272 doxorubicin 8.13 µM -2.2798489009348 0.0100700175416345 no 3296 0.0113083257905011 4744 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2860 9025725 38.96 µM -2.28331389166563 0.00997661714147557 no 3297 0.0112059426584226 4749 40546248
SGTC_715 0868-0130 184 µM -2.29268873041741 0.00972769512441052 no 3298 0.010932965908564 4771 2876258
SGTC_1655 st012546 55.1 µM -2.29547012581029 0.00965489461623219 no 3299 0.0108530982776864 4737 720985 YLR208W SEC13
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -2.30237851842294 0.00947613010994084 no 3300 0.0106569176625598 4735 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1742 st038235 28.8875 µM -2.32847941379725 0.00882659609046826 no 3301 0.00994333056184062 4737 564103 YBR002C RER2
SGTC_964 1287-0107 19.4 µM -2.33433388150812 0.00868638040285897 no 3302 0.00978912297167672 4729 51516812 YPR165W RHO1
SGTC_2074 5212007 75.395 µM -2.33818038093178 0.00859532270951612 no 3303 0.00968894640491954 4720 758611
SGTC_710 3448-4187 58 µM -2.34599559004189 0.00841288977944501 no 3304 0.00948816599644628 4722 3946412
SGTC_1857 st056007 79.3 µM -2.34650573908857 0.00840110026616288 no 3305 0.00947518718217605 4743 619834
SGTC_1227 3909-8010 46.6 µM -2.35117906125065 0.008293773306624 no 3306 0.009357012870934 4756 15982272
SGTC_720 r052-1644 49.9 µM -2.37670098987403 0.00772862477608393 no 3307 0.00873412091993046 4747 1422863 YOR257W CDC31
SGTC_2809 7964133 12.99 µM -2.39863493018407 0.00727029815613711 no 3308 0.00822815614353777 4724 1253665
SGTC_2178 5812956 200 µM -2.4011044449517 0.00722022749646013 no 3309 0.00817283515492215 4735 5403383
SGTC_2865 9030313 51.95 µM -2.4087583601353 0.00706696713264988 no 3310 0.00800344609436426 4741 42562754
SGTC_3027 9089541 49.47 µM -2.41947041176403 0.00685729365847608 no 3311 0.00777156258688582 4743 9943819
SGTC_2315 7733312 200 µM -2.42503896638735 0.00675048275186924 no 3312 0.00765337185726827 4710 726316
SGTC_1207 2099-0101 141 µM -2.4574936276867 0.00615673102120533 no 3313 0.00699551464245167 4769 5837381
SGTC_1242 0402-0103 60.1 µM -2.46027258066198 0.00610810846126603 no 3314 0.00694157641052516 4706 432868
SGTC_1015 4130-4525 82 µM -2.48160789286341 0.00574600640119069 no 3315 0.00653955542151549 4761 1363237
SGTC_2322 7413319 38.22 µM -2.52952121167368 0.00500141892708379 no 3316 0.00571091348925783 4709 1840400
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -2.5447063444544 0.0047840676984856 no 3317 0.00546848357308173 4774 390807
SGTC_2970 9090938 41.86 µM -2.55331806835247 0.00466458309886182 no 3318 0.00533510031314553 4756 17217104
SGTC_732 3970-1727 52.7 µM -2.57164485520719 0.00441912785404724 no 3319 0.00506083312436941 4779 1275699
SGTC_886 0866-0150 153 µM -2.63800747062413 0.00362399649085966 no 3320 0.00416973723384542 4781 271463
SGTC_1991 st073000 8.92 µM -2.64240821898714 0.00357611687440537 no 3321 0.00411593863404322 4774 4301969 YIL048W NEO1
SGTC_3107 9121808 49.47 µM -2.66113767836183 0.00337863189200909 no 3322 0.00389385530373078 4758 662681
SGTC_2711 st079103 59.1 µM -2.6700127224839 0.00328852134868166 no 3323 0.00379241864872271 4777 54693780
SGTC_2022 5136654 200 µM -2.67554813739753 0.00323341910760544 no 3324 0.0037303579137855 4752 1713771
SGTC_2996 9066192 71.4286 µM -2.67897119720685 0.00319976131402178 no 3325 0.00369243729762984 4750 6472854
SGTC_2017 5132927 60.65 µM -2.68898943563488 0.00310305924978305 no 3326 0.00358343436420898 4757 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2097 5376186 200 µM -2.70495151921094 0.00295441062673703 no 3327 0.00341571794010453 4775 742755
SGTC_2982 9019404 25.97 µM -2.7702932821756 0.00241055037072102 no 3328 0.00280029190569669 4749 22333232
SGTC_1068 loratadine 26.9 µM -2.78807009283234 0.00227917089395913 no 3329 0.00265115351263028 4790 3957 A H1 histamine antagonist.
SGTC_881 0833-0569 170 µM -2.79344488504129 0.00224074533198899 no 3330 0.00260749574800603 4786 5418700
SGTC_2161 5662504 8.5105 µM -2.79352357392131 0.00224018715403478 no 3331 0.0026068614356381 4786 2859334
SGTC_2623 humulene 100 µM -2.79719704169782 0.00221426928945271 no 3332 0.00257740427382631 4759 6187145 An anti-inflammatory.
SGTC_738 1315-0003 72.4 µM -2.81309145480123 0.00210523067087314 no 3333 0.00245338467711811 4784 6251474
SGTC_3100 9120536 49.47 µM -2.85853061639789 0.00181984052720979 no 3334 0.0021280401769417 4751 16421196
SGTC_2708 st078559 56 µM -2.86913210388668 0.00175853428481553 no 3335 0.00205799924867492 4788 17250902
SGTC_2897 9048598 12.99 µM -2.94302103131406 0.00138084127594788 no 3336 0.00162513168428681 4781 6467404
SGTC_2707 st078556 66.6 µM -2.98675181362316 0.00119382014499634 no 3337 0.0014097926085307 4783 17250899
SGTC_2037 5169046 200 µM -2.99136567352947 0.00117550508433675 no 3338 0.00138866348198071 4799 5718022
SGTC_3199 9111318 49.47 µM -3.0141434000378 0.00108880067828873 no 3339 0.00128852983325835 4758 8548020
SGTC_695 3505-6186 243 µM -3.05064408973121 0.000962007334415967 yes 3340 0.00114175541120968 4778 1819379
SGTC_2572 astragaloside iv 100 µM -3.06903479538628 0.000903396492352351 yes 3341 0.00107375788720414 4776 45006101 An anti-inflammatory agent.
SGTC_2714 st079313 56.9 µM -3.08684644700719 0.000849776834961857 yes 3342 0.0010114603215858 4796 2939799
SGTC_946 3434-1334 87.4 µM -3.1443451410328 0.000696028269143176 yes 3343 0.000832294935371673 4795 4047976
SGTC_2873 9040596 71.43 µM -3.18928293711507 0.000594198914905484 yes 3344 0.000713131031663732 4789 6463863
SGTC_1750 st081859 2.357 µM -3.2130843319598 0.000546019944267309 yes 3345 0.000656588627750137 4761 5291695
SGTC_3234 9132280 49.47 µM -3.4788599940549 0.000204714909807933 yes 3346 0.000251775795759431 4805 17612295
SGTC_140 0062-0056 502.533 µM -3.52275394093551 0.00017296224869713 yes 3347 0.000213543836706396 4774 3758964
SGTC_3277 9138724 49.47 µM -3.64573537189605 0.000106800541023118 yes 3348 0.00013331412230686 4800 15943418
SGTC_2395 5646831 180.19 µM -3.69630417085492 8.72249255524856e-05 yes 3349 0.000109380428222536 4792 6808628
SGTC_2325 6158266 200 µM -3.78638500183086 6.04424020215667e-05 yes 3350 7.64273931285607e-05 4797 3623240
SGTC_2626 ethyl orsellinate 100 µM -3.80073716693469 5.69700216931552e-05 yes 3351 7.21331314748238e-05 4790 75653 A natural product.
SGTC_1231 0242-0792 125 µM -3.9346768710798 3.2483844228466e-05 yes 3352 4.16543502957393e-05 4808 3707635
SGTC_2513 baicalein 25.65 µM -4.01279295118336 2.32210921981108e-05 yes 3353 3.000227069785e-05 4805 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3101 9120531 49.47 µM -4.1007457905797 1.57999339920444e-05 yes 3354 2.0591038089686e-05 4807 24824904
SGTC_433 pimozide 108 µM -4.31973226790213 5.8622298503265e-06 yes 3355 7.81093054030329e-06 4804 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic