SGTCid condition conc unit RPL20B|YOR312C.score RPL20B|YOR312C.strain.pval RPL20B|YOR312C.strain.significant RPL20B|YOR312C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1712 st032288 53.4 µM 9.67268957907591 2.54669030453036e-22 yes 1 1.96943878643663e-22 27 2883011 SGTC_118 0083-0097 135.343 µM 6.1292477908403 3.65850697594521e-10 yes 2 4.41477601639582e-10 21 5207356 SGTC_856 0433-0016 11.3 µM 5.99502868104742 8.35231108991404e-10 yes 3 1.01724766024112e-09 1 3911780 SGTC_1683 st010134 710 nM 5.73095164324493 4.03250755471134e-09 yes 4 4.99343685830995e-09 5 3818134 SGTC_117 lucigenin 22.078 µM 5.62490411939698 7.44929742718355e-09 yes 5 9.28055201194954e-09 44 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2688 kanamycin b 96.69 µM 5.54516876044559 1.17351653394044e-08 yes 6 1.46835393214553e-08 192 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_309 k408-0051 1.48 µM 4.8159916837458 5.67569248512913e-07 yes 7 7.3235311858705e-07 32 3640463 SGTC_2972 9093619 59.92 µM 4.81128891933982 5.8100544646894e-07 yes 8 7.49800271636721e-07 9 25236256 SGTC_2339 9000433 200 µM 4.4102051059051 3.96100091601857e-06 yes 9 5.16363778421437e-06 23 2988954 SGTC_1923 st058458 19.1 µM 4.37730606040681 4.60567772300377e-06 yes 10 6.00775970892208e-06 23 3534982 SGTC_187 1488-2104 32.728 µM 4.35544781156067 5.0881824519576e-06 yes 11 6.63975770576498e-06 29 2852859 SGTC_1367 1812-0510 76.9 µM 4.10038608711414 1.57478893019902e-05 yes 12 2.06230713999411e-05 17 1142582 YDR527W RBA50 SGTC_3169 9102970 49.47 µM 3.96048231286311 2.85256505978012e-05 yes 13 3.73992666759193e-05 2 17027839 SGTC_40 0327-0103 19.753 µM 3.73784614910451 7.07364348326416e-05 yes 14 9.28017296869374e-05 38 409036 SGTC_449 xestospongin c 11.1929 µM 3.64273328308729 0.000102824708215016 yes 15 0.000134879156631596 84 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1225 1216-0074 20.6 µM 3.62779290459898 0.000108965234631401 yes 16 0.000142927199844909 33 4241466 SGTC_3173 9105693 49.47 µM 3.59649815667128 0.000122960238808627 yes 17 0.000161264934018716 35 17096658 SGTC_2400 5203494 178.7 µM 3.56284045732627 0.000139884129376727 yes 18 0.000183431828935339 33 6777674 SGTC_146 3448-8650 53.125 µM 3.53873530024986 0.000153320575848036 yes 19 0.000201024392473876 171 2891488 YIL048W NEO1 SGTC_451 chloral hydrate 100 µM 3.52262611975448 0.000162963685186498 yes 20 0.000213646841599454 74 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2156 5649887 115 µM 3.52249101642702 0.000163046908428781 yes 21 0.000213755765251397 26 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1401 3807-4679 7.6 µM 3.49274971721355 0.000182367460989435 yes 22 0.000239037181680016 30 3291456 SGTC_1180 1193-0155 285 µM 3.48435625952028 0.000188195505597483 yes 23 0.000246661181281971 27 2921347 SGTC_2809 7964133 12.99 µM 3.42582535856061 0.000233938311861182 yes 24 0.000306467173192421 64 1253665 SGTC_464 bw-b 70c 158 µM 3.25564034671292 0.000432647992957215 yes 25 0.000565684825285806 53 5353454 SGTC_3245 9134821 49.47 µM 3.25521190281929 0.000433303800809053 yes 26 0.000566538949800622 40 17014901 SGTC_2125 5246583 200 µM 3.24503945154617 0.000449147858405066 yes 27 0.000587171763997882 82 835267 SGTC_343 4130-2827 29.8 µM 3.23477311675885 0.000465681184860138 yes 28 0.000608697132324042 62 1118244 SGTC_25 0118-0223 35.662 µM 3.20054523174699 0.000524964265762166 yes 29 0.000685839190723743 44 5333628 SGTC_1464 k208-0027 110 µM 3.18691632151608 0.000550456368718569 yes 30 0.00071899185549004 45 X1464 SGTC_838 0109-0203 71.4 µM 3.17952156841961 0.000564762253571768 yes 31 0.000737591953242022 45 759422 SGTC_2314 7727897 200 µM 3.1343168117518 0.000659954429254937 yes 32 0.00086127384694701 52 900724 SGTC_1596 piperlongumine 63 µM 3.13016333278413 0.000669405398731866 yes 33 0.000873545665173861 46 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2401 5128683 200 µM 3.11749891802147 0.00069899868717624 yes 34 0.000911963081161389 74 708373 SGTC_718 1130-0073 349 µM 3.11214612644148 0.000711865653912198 yes 35 0.000928662696369576 55 6740020 SGTC_1316 1272-0050 65.9 µM 3.07323406114247 0.000812168195086726 yes 36 0.00105876165035599 33 7340392 SGTC_1917 st066507 28.5 µM 3.05189889479821 0.000872533302871885 yes 37 0.00113699340683539 98 3156428 SGTC_1929 genistein trimethyl ether 50.5 µM 3.03471504766049 0.000924122971701817 yes 38 0.0012038152187204 51 136420 SGTC_258 haloperidol 50.781 µM 3.01340260430196 0.00099199733416049 yes 39 0.00129167973961542 81 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_355 1311-2252 105 µM 3.00747974268258 0.00101165639534612 no 40 0.0013171184034563 64 5338538 SGTC_232 clozapine 119 µM 2.98960459496611 0.0010731750391577 no 41 0.00139669395589813 112 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2512 diallyl trisulfide 49.23 µM 2.98510454774417 0.00108919352397745 no 42 0.00141740708292165 36 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_155 k072-0202 43.6 µM 2.95333360893959 0.00120866993038997 no 43 0.00157181014558966 50 5857737 SGTC_1448 4255-0083 152 µM 2.94833830756106 0.00122851063230309 no 44 0.00159743611018045 62 5399660 SGTC_163 TUB2.036 7.546 µM 2.94107835731869 0.00125787788886383 no 45 0.00163535892808138 199 15992207 YJR013W GPI14 SGTC_840 0245-0196 390 µM 2.93787242269982 0.00127104948366255 no 46 0.00165236492249059 51 3827528 SGTC_517 1365-0151 113 µM 2.90371048200685 0.00141944846414799 no 47 0.00184384499232492 84 768657 SGTC_1461 k072-0203 53.8 µM 2.90129440287634 0.00143052052590754 no 48 0.00185812277071181 64 5418714 SGTC_1931 st074438 57.1 µM 2.90023179958093 0.00143541499027694 no 49 0.001864433969534 63 2787313 SGTC_1457 k015-0032 57.3 µM 2.87486962430516 0.00155686850833201 no 50 0.00202097180567838 106 4302660 SGTC_2403 6032726 181.2 µM 2.87321661011516 0.0015651006649424 no 51 0.00203157712879377 93 2881040 SGTC_1631 benzylvanillin 81.9 µM 2.86749123099411 0.00159392124253111 no 52 0.0020687013488215 86 75506 SGTC_980 1473-0395 201 µM 2.86732582709564 0.00159476100017216 no 53 0.00206978294294275 48 768876 SGTC_194 1486-1323 56.904 µM 2.85745218617181 0.00164562611119633 no 54 0.00213528484789481 59 5178754 SGTC_37 0566-0070 1.56 µM 2.84841076739801 0.00169349558208072 no 55 0.00219690864811784 95 1626686 SGTC_2062 5245942 200 µM 2.83241159048848 0.00178131975678509 no 56 0.00230991698256868 73 1376160 SGTC_1424 4048-1941 275 µM 2.81012308951932 0.00191057933576964 no 57 0.00247612780311141 81 X1424 SGTC_2515 chrysin 20.77 µM 2.80303583129285 0.0019534326275934 no 58 0.00253120223405519 49 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_7 0192-1582 4.227 µM 2.79293091815836 0.00201604269880659 no 59 0.00261164227472285 155 252616 SGTC_2154 5570129 200 µM 2.77105092442877 0.00215789697216945 no 60 0.00279378436906388 89 673366 SGTC_872 0588-0139 234 µM 2.76231507938009 0.00221701829451976 no 61 0.00286965314161196 108 2047100 SGTC_1359 1582-0056 520 nM 2.74245738466648 0.00235690557421177 no 62 0.00304906810800596 82 3661189 SGTC_2293 7624732 200 µM 2.72940705976942 0.00245313957532639 no 63 0.00317241655272146 86 894453 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.70696975976511 0.00262693344456663 no 64 0.00339502210563558 157 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_422 cantharidin 155 µM 2.70651471026202 0.00263057044142388 no 65 0.00339967849796009 147 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3083 9117465 49.47 µM 2.70153439100438 0.00267067415192367 no 66 0.00345101709666049 114 16420915 SGTC_1647 st011722 22.4 µM 2.69974743915639 0.00268519752418335 no 67 0.00346960662067661 65 2854783 SGTC_1575 cyproterone acetate 48 µM 2.69141172641201 0.00275389235940332 no 68 0.00355751624306549 96 9880 An androgen receptor antagonist and liver toxin. SGTC_973 1325-0077 65.9 µM 2.6806184823328 0.00284519501119086 no 69 0.00367431223225519 71 2835149 SGTC_2053 5265679 138 µM 2.67759364772453 0.00287126803900556 no 70 0.00370765599938014 113 764595 SGTC_2315 7733312 200 µM 2.66670547190952 0.00296691352176998 no 71 0.00382993836646472 88 726316 SGTC_1905 st060207 84.5 µM 2.66606100295573 0.00297266374885134 no 72 0.00383728827918458 68 1948547 SGTC_849 0386-0493 241 µM 2.6638303552693 0.00299264415993567 no 73 0.00386282563362257 84 726119 SGTC_600 1495-0418 41.6 µM 2.65713094662809 0.00305338178198642 no 74 0.00394044125593323 69 5377768 SGTC_3002 9075603 71.4286 µM 2.64674028840989 0.00314978302126579 no 75 0.00406358714947033 100 20105405 SGTC_3076 9116187 49.47 µM 2.61388429214357 0.00347289908060599 no 76 0.00447596738356882 85 27241210 SGTC_735 3076-0345 636 µM 2.60613541806368 0.0035533158061772 no 77 0.00457851252623756 132 2888990 SGTC_2985 9022375 71.43 µM 2.60545967635099 0.00356040719648178 no 78 0.00458755363727893 124 4939335 SGTC_1363 1636-0063 10.4 µM 2.60279968417338 0.00358844537616961 no 79 0.0046232981203119 129 6072185 SGTC_125 0133-0007 11.75 µM 2.59764431153319 0.00364335152053715 no 80 0.00469328342651703 82 26541 SGTC_796 1234-0020 70.7 µM 2.57790361108697 0.00386063191805777 no 81 0.00497008605472162 91 46495034 SGTC_3179 9107801 49.47 µM 2.55443611037689 0.00413398988697274 no 82 0.00531799734708041 81 4818259 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.52998020109343 0.00443716737975642 no 83 0.00570344816135704 115 6708514 SGTC_1458 k015-0034 6.33 µM 2.52571690434908 0.00449200643112705 no 84 0.00577312405642628 90 3598957 SGTC_2926 9010726 65.15 µM 2.47384813834893 0.00520933328854773 no 85 0.00668332505895534 132 2994293 SGTC_1867 st057372 64 µM 2.45649969852474 0.00547106094390173 no 86 0.00701489599337942 98 688837 SGTC_342 k048-0088 23.3 µM 2.44397067931115 0.00566728242278799 no 87 0.00726330353809684 115 6820570 SGTC_1425 4048-4433 7.33 µM 2.44200752413314 0.00569858787217575 no 88 0.00730292110512212 153 23734946 SGTC_1223 0764-0573 147 µM 2.44031029545267 0.00572577635220344 no 89 0.00733732554638347 140 1609797 SGTC_1694 st024011 44.9 µM 2.4386891911156 0.00575185281477455 no 90 0.00737032019534796 135 2787533 SGTC_903 1134-0042 114 µM 2.43081926639713 0.00587994901536016 no 91 0.00753236354384756 130 701009 SGTC_2621 lithochol-11-enic acid 100 µM 2.40236728390844 0.00636441463916541 no 92 0.00814467207751896 162 6708711 SGTC_234 nsc-17383 10.7 µM 2.38630543707283 0.00665323145136658 no 93 0.00850930494817821 148 408974 SGTC_1807 st050092 58.9 µM 2.38006053582972 0.00676861527121092 no 94 0.00865489708166366 131 5008496 SGTC_1863 st057641 20.1 µM 2.35022507891862 0.00734461462442138 no 95 0.00938103094609635 135 3921635 SGTC_2807 7945238 51.95 µM 2.32966676102602 0.0077662492510175 no 96 0.00991188531362446 172 17148797 SGTC_2694 st077685 81.9 µM 2.32897615281697 0.00778077552778117 no 97 0.00993016453556383 165 2838096 SGTC_2350 9023895 38.85 µM 2.32571461920795 0.00784970228890553 no 98 0.0100168900346292 150 2997209 SGTC_691 1548-0686 185 µM 2.32483583956215 0.00786836536505105 no 99 0.0100403699018813 190 46495133 SGTC_1285 0929-0069 65.5 µM 2.31306750611301 0.00812208239675061 no 100 0.0103594639541408 149 1206237 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.31198893410729 0.00814569140994671 no 101 0.0103891465691569 130 4213774 SGTC_2443 5493264 126.67 µM 2.29754502933883 0.00846771574706861 no 102 0.0107938487003839 137 5340055 SGTC_3194 9111903 49.47 µM 2.29222489252936 0.00858911275233913 no 103 0.0109463346265704 148 17087251 SGTC_1103 duloxetine 36.1 µM 2.28165877160073 0.00883474927735249 no 104 0.011254746979334 182 60835 A selective serotonin reuptake inhibitor. SGTC_1485 3909-9022 254 µM 2.2714098682813 0.00907887183666714 no 105 0.011561088788875 126 714516 SGTC_1781 st038725 66.3 µM 2.25928250099577 0.0093753514684956 no 106 0.0119329088590481 265 4270275 YIL048W NEO1 SGTC_1670 st016595 4.04 µM 2.25575471153767 0.00946317097016576 no 107 0.0120429985273506 145 597879 SGTC_2370 9071495 200 µM 2.24342985009543 0.00977565300545779 no 108 0.0124345543959981 179 21791103 SGTC_782 0083-0095 30.5 µM 2.2325882105885 0.0100579435686359 no 109 0.0127880561329647 195 3591729 An indicator and reagent. SGTC_2571 chrysanthemic acid 100 µM 2.22563380887095 0.0102427421018874 no 110 0.0130193598401389 140 2743 An insecticide. SGTC_1804 st050076 49.1 µM 2.22042559213558 0.0103830721018138 no 111 0.0131949457075436 157 3895976 SGTC_2358 9037157 4 µM 2.20945441111744 0.0106841727939062 no 112 0.0135715250104886 187 2388925 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.18909943479946 0.0112629910679499 no 113 0.0142948068075449 244 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3070 9117005 49.47 µM 2.18895167782902 0.0112672904545874 no 114 0.0143001761951372 95 8779016 SGTC_1361 1608-0041 5.61 µM 2.18340909234035 0.0114296006040434 no 115 0.0145028484835817 164 X1361 SGTC_123 0083-0120 66.675 µM 2.17740904659104 0.0116075930831445 no 116 0.0147250306502798 206 16001701 SGTC_3140 9094243 49.47 µM 2.17699146564262 0.0116200697944622 no 117 0.0147406021052777 196 19291112 SGTC_2268 7933382 153.85 µM 2.16264670555713 0.0120557987867412 no 118 0.0152841815294698 232 935025 YOR257W CDC31 SGTC_2296 7971656 126.45 µM 2.16195594545114 0.0120771338143603 no 119 0.0153107860360804 200 666570 SGTC_512 prima-1 270 µM 2.14638489747328 0.012566826654765 no 120 0.0159211416195228 168 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3006 9075424 71.4286 µM 2.13842327929854 0.0128237867550647 no 121 0.0162412023804464 175 7465181 SGTC_1719 st032227 49.2 µM 2.120738053333 0.0134108834164114 no 122 0.0169719261489456 185 3125804 SGTC_1597 7-benzyloxygramine 47.5 µM 2.11748099242754 0.0135215022458273 no 123 0.0171095233975509 385 260807 SGTC_2508 celastrol 40.54 µM 2.11619025275891 0.0135655567627624 no 124 0.0171643149429747 147 122724 Celastrol is a natural product and antioxidant. SGTC_756 0508-1999 28.3 µM 2.10791136289955 0.0138510815197503 no 125 0.0175193285811374 180 6753853 SGTC_3276 9139060 49.47 µM 2.08109367010513 0.0148118390455333 no 126 0.0187126665628708 130 4870619 SGTC_338 4055-0136 114 µM 2.07641715854597 0.0149851173203556 no 127 0.0189276928259563 200 2900563 SGTC_75 0159-0059 199.013 µM 2.06610522952067 0.0153733707737941 no 128 0.0194092722837478 190 5377270 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.06472839626791 0.0154258577931607 no 129 0.0194743530994481 255 2724 A muscle relaxant with antifungal properties. SGTC_1952 st077036 64.1 µM 2.0586500276435 0.0156594173922752 no 130 0.0197638883022025 218 2937007 SGTC_1415 3966-0071 78.1 µM 2.05567726627406 0.0157747454307306 no 131 0.019906817312504 156 2893185 SGTC_3324 9138759 60.749 µM 2.03851203756019 0.0164550140394738 no 132 0.0207493760767714 193 45595710 SGTC_1444 4112-3581 28 µM 2.03659121830069 0.016532677214371 no 133 0.0208455117738583 200 2877249 SGTC_2960 9079389 5.97 µM 2.03516223446395 0.0165906576758828 no 134 0.0209172758184432 215 16457355 SGTC_1977 st070720 65.3 µM 2.03002616080138 0.0168004907871088 no 135 0.0211769400839843 167 682188 SGTC_1436 4092-1007 8.32 µM 2.02883795249376 0.0168493568001614 no 136 0.0212373991318854 194 2881121 SGTC_2203 7227154 166.4 µM 2.01101587828783 0.0175970144237348 no 137 0.0221618897930456 177 896304 SGTC_296 1222-0039 74.9 µM 1.99029521841272 0.0185016967161578 no 138 0.0232792122197199 196 5984176 SGTC_2749 bexarotene 57.39 µM 1.98729479123587 0.0186359255834531 no 139 0.0234448692783485 262 82146 An retinoic acid receptor inhibitor. SGTC_3181 9108277 49.47 µM 1.97184149866407 0.0193404545320816 no 140 0.0243138516667228 213 17097298 SGTC_770 0389-1121 67.2 µM 1.96255055274106 0.0197748348070319 no 141 0.0248492105518613 279 6753108 SGTC_2819 7996655 46.38 µM 1.96109383522379 0.0198436862397261 no 142 0.0249340388732747 197 6456960 SGTC_2407 paclitaxel 400 µM 1.95092473698048 0.0203300162198551 no 143 0.0255329997587706 279 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_90 0870-0863 4.608 µM 1.94768197180235 0.0204872083443896 no 144 0.0257265142896502 274 1738164 SGTC_2558 carylophyllene oxide 100 µM 1.93654024180423 0.0210351709406639 no 145 0.0264007844253675 228 6708694 An oxygenated terpenoid and antifungal agent. SGTC_519 k048-0011 62.8 µM 1.93396447757276 0.0211635999998057 no 146 0.0265587477582645 242 6836379 SGTC_452 diindolylmethane 8 µM 1.92964937472793 0.021380239777713 no 147 0.0268251483137495 189 3071 Inhibits expression of several cancer promoting factors. SGTC_1068 loratadine 26.9 µM 1.92172435289373 0.0217830006405223 no 148 0.0273202256371163 237 3957 A H1 histamine antagonist. SGTC_2951 9072950 58.06 µM 1.91759147699749 0.0219955695607612 no 149 0.0275814158453513 261 16488155 SGTC_497 capsazepine 133 µM 1.91502719815027 0.0221283381570374 no 150 0.027744517560775 219 2733484 A calcium channel blocker. SGTC_32 0928-0142 34.1 µM 1.91460303390908 0.0221503648295737 no 151 0.0277715739658572 190 2244242 SGTC_3020 9089140 49.47 µM 1.91141965330426 0.0223162677305784 no 152 0.0279753365236987 246 17217859 SGTC_120 rhodamine 6G 52.259 µM 1.90567234674152 0.0226184453654072 no 153 0.0283463646184505 326 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2488 5268135 45.7 µM 1.90234766631839 0.0227948175343645 no 154 0.0285628589702746 331 1270356 YLR208W SEC13 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.89901245456876 0.0229729113722264 no 155 0.0287814192335738 275 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3029 9088683 49.47 µM 1.89529773885258 0.0231726481710568 no 156 0.0290264837876187 241 25236615 SGTC_629 3448-6466 76.7 µM 1.88737507804131 0.0236035299706572 no 157 0.0295549473678632 267 573744 SGTC_273 hydroxyurea 18.1 mM 1.87913685867717 0.0240587003448419 no 158 0.0301129042292661 319 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1149 3909-7961 23.3 µM 1.87474627601532 0.0243042824163192 no 159 0.0304138186451414 257 735261 SGTC_333 3486-0131 40.1 µM 1.8720741560298 0.0244547721606195 no 160 0.030598172444343 248 6744690 SGTC_1254 0550-0035 264 µM 1.87175860194735 0.0244725952169787 no 161 0.0306200039927384 279 15121435 SGTC_625 k213-0058 121 µM 1.85486405084475 0.0254428734349062 no 162 0.0318078213442199 441 3655420 SGTC_2104 5389443 200 µM 1.83790039621234 0.02644933215164 no 163 0.0330385418648332 302 2244536 SGTC_177 1327-0068 8.361 µM 1.83181909671959 0.0268181459051973 no 164 0.0334891885609445 311 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2537 larixol 68.93 µM 1.83101188965011 0.0268674220436005 no 165 0.0335493842297756 294 6708759 SGTC_1156 4092-0367 4.88 µM 1.82924924504483 0.0269752858708647 no 166 0.0336811391327602 299 1357585 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.82729786549113 0.0270951205383577 no 167 0.033827498000924 298 5377381 SGTC_1700 st030840 7.9285 µM 1.82567900935517 0.0271948716994209 no 168 0.0339493134035688 269 5499307 SGTC_1060 3448-7350 82 µM 1.82335499840744 0.0273386087760518 no 169 0.0341248207094254 302 570178 SGTC_667 1498-1044 59 µM 1.81110549311103 0.0281067348930566 no 170 0.0350622616968642 277 6739982 SGTC_3255 9139072 49.47 µM 1.7939577313126 0.0292121252995634 no 171 0.0364099578391687 274 17646060 SGTC_2467 5474540 200 µM 1.79119208559444 0.0293937439587703 no 172 0.0366312379105403 305 5413519 SGTC_1886 st057356 49.9 µM 1.78842667707447 0.0295762835042843 no 173 0.0368535977588749 277 24207747 SGTC_985 1493-0307 8.71 µM 1.78759566015274 0.0296313209075684 no 174 0.0369206330838044 226 3278274 SGTC_61 0978-8327 98.565 µM 1.78356219217509 0.0298996621530991 no 175 0.037247416862395 311 6150059 YHR072W ERG7 SGTC_2595 hexamethylquercetagetin 100 µM 1.78212873409288 0.0299955123492915 no 176 0.0373641205016988 266 386331 SGTC_3274 9138298 49.47 µM 1.77872676937605 0.0302240097863308 no 177 0.03764228410042 304 17015756 SGTC_557 1315-0110 16.2 µM 1.77203953947647 0.0306773723212897 no 178 0.0381939970022482 301 6833801 SGTC_648 0375-0473 33.3 µM 1.77073767862942 0.0307662839507219 no 179 0.0383021668608412 329 1713139 SGTC_2932 9016711 44.54 µM 1.76004971196345 0.0315043218193748 no 180 0.0391996890724698 341 7117328 SGTC_3045 9092950 49.47 µM 1.75761812569706 0.0316742583358329 no 181 0.0394062535727009 307 44120432 SGTC_1302 1159-0335 255 µM 1.74026631455142 0.0329090360081234 no 182 0.040906133024401 288 649284 SGTC_2808 7946468 45.46 µM 1.73820042091136 0.0330586557616237 no 183 0.0410877524882915 357 2970879 SGTC_2737 bleomycin 30.5 nM 1.73409846413018 0.033357396259128 no 184 0.0414503069992646 370 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2138 5575593 77.673 µM 1.7264483593611 0.0339204825393031 no 185 0.0421333910486366 249 762213 SGTC_2944 9067346 25.62 µM 1.72349214994367 0.0341401583946937 no 186 0.0423997817733333 342 6473075 SGTC_843 0310-0051 143 µM 1.72202970721506 0.0342492641498557 no 187 0.0425320685943872 305 2065037 SGTC_2083 5306046 65.942 µM 1.72107047327457 0.0343209834638053 no 188 0.0426190182406688 349 539837 SGTC_527 4476-4215 268 µM 1.72090969230248 0.0343330166893647 no 189 0.0426336062666417 333 4418754 SGTC_977 1348-1378 135 µM 1.71715570654822 0.0346149607776418 no 190 0.0429753630506698 302 X977 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.70830095073711 0.0352875376593384 no 191 0.0437902574983281 321 165521 SGTC_2977 9011197 71.43 µM 1.70738350914102 0.0353578320940345 no 192 0.0438753967282282 260 2704722 SGTC_2695 st077686 51.995 µM 1.70626976909114 0.0354433212147897 no 193 0.0439789319666431 293 2876092 SGTC_1265 0819-1001 68.8 µM 1.70601731175584 0.035462723030201 no 194 0.0440024282169481 320 3106768 SGTC_2680 butyl paraben 22.24 µM 1.70584222239523 0.0354761840864826 no 195 0.0440187297598483 259 7184 An antifungal and steroid mimetic. SGTC_1652 st011932 78 µM 1.70385561214467 0.035629210435301 no 196 0.0442040326885894 301 1551076 SGTC_3056 9094900 49.47 µM 1.69776780102404 0.0361015201338804 no 197 0.0447757976688096 344 25236784 SGTC_1987 st072290 61.9 µM 1.69589703774124 0.0362476849075922 no 198 0.0449526903822931 322 54697379 SGTC_652 0437-0092 114 µM 1.6958107392279 0.0362544391771644 no 199 0.0449608640164982 281 3091274 SGTC_3038 9091290 49.47 µM 1.69555017973566 0.0362748384692663 no 200 0.0449855497768643 325 25236843 SGTC_364 0083-0097 67.7 µM 1.68899742316261 0.0367909531218982 no 201 0.0456099618866432 327 5207356 SGTC_599 1935-0052 86.5 µM 1.68716186085002 0.0369365993400865 no 202 0.0457861163844648 348 9557311 SGTC_2967 9089538 49.85 µM 1.68563841448439 0.0370578377764985 no 203 0.0459327327366413 367 728216 SGTC_2793 7325131 81.82 µM 1.68329343351306 0.0372450908024854 no 204 0.0461591504832892 305 4176441 SGTC_3026 9090633 49.47 µM 1.6672825721303 0.0385443537777639 no 205 0.0477291151989827 328 25236842 SGTC_1787 fluconazole 80 µM 1.66494515697231 0.0387370857841649 no 206 0.047961848956987 431 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2709 st078560 56 µM 1.6612161768573 0.0390461842128741 no 207 0.0483350188843354 316 17250903 SGTC_3231 9132313 49.47 µM 1.6567340023778 0.0394203697951566 no 208 0.0487866326627722 326 4905967 SGTC_3278 9139605 49.47 µM 1.65260300461933 0.0397678165061329 no 209 0.0492058430951483 344 7958859 SGTC_2149 5554786 194.827 µM 1.65159692922289 0.0398528106368555 no 210 0.0493083732228307 392 745063 YPR165W RHO1 SGTC_277 nystatin 15.5 µM 1.64983646731616 0.0400018912139487 no 211 0.0494881939476168 360 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_684 1140-0066 328 µM 1.64652214036155 0.0402837867926812 no 212 0.0498281528025389 389 6813534 SGTC_233 rapamycin 362 pM 1.64073327218679 0.0407800197399231 no 213 0.0504263975197356 344 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2151 5563267 85.4165 µM 1.63648949003678 0.0411469466335866 no 214 0.0508685917715311 365 5310824 SGTC_1802 st050112 57.9 µM 1.63599074782804 0.0411902442392817 no 215 0.0509207618941433 337 4662563 SGTC_323 4013-0906 34.3 µM 1.62884341829748 0.0418147968222278 no 216 0.0516730853187889 321 2910086 SGTC_729 4092-0585 94.1 µM 1.62874286752085 0.0418236376136782 no 217 0.0516837319205344 326 2169061 SGTC_1574 spiramycin 23.7 µM 1.62774672274345 0.0419113040997492 no 218 0.0517893007956382 388 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2663 amphotericin b 100 µM 1.61791888202078 0.0427842086896295 no 219 0.0528400402271468 340 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1669 st015249 58.4 µM 1.61732485414055 0.0428374374517211 no 220 0.0529040885274647 312 722793 SGTC_1045 1348-1485 165 µM 1.61617987421486 0.0429401860983634 no 221 0.0530277143984262 430 6810614 SGTC_1999 st074831 12.5 µM 1.61205797737135 0.0433117283954962 no 222 0.0534746620089204 388 17112523 SGTC_1866 st057638 64 µM 1.60940526132626 0.0435522105337762 no 223 0.0537638777956249 338 688802 SGTC_447 ml7 120 µM 1.60537029072711 0.0439200661842373 no 224 0.054206169267818 364 4216 Selective myosin light chain kinase inhibitor. SGTC_2391 6285546 200 µM 1.60405676896862 0.0440403550962056 no 225 0.0543507699457235 402 846083 SGTC_1392 3455-1037 33.9 µM 1.60100907721497 0.0443204781642127 no 226 0.0546874543379247 354 981132 SGTC_2310 7668677 200 µM 1.60058986188323 0.0443591216794928 no 227 0.0547338945959793 369 2197143 SGTC_3279 9140807 49.47 µM 1.59742871136314 0.0446513934561743 no 228 0.0550850883562118 339 45595718 SGTC_1339 1486-1321 22.7 µM 1.59440679191856 0.0449322403991219 no 229 0.0554224760873715 379 3469382 SGTC_630 4356-0227 183 µM 1.5803194060808 0.046260292166731 no 230 0.0570168689359676 347 779312 SGTC_26 0302-0163 425.158 µM 1.57854424478964 0.0464298543559084 no 231 0.0572203159878017 339 3100915 SGTC_681 1642-0006 26.6 µM 1.57470734315006 0.0467980571632714 no 232 0.057662006035378 313 4446530 SGTC_1806 st050005 60.3 µM 1.57081941976854 0.0471735417524953 no 233 0.0581122999561673 374 5194765 SGTC_2499 avocadenofuran 51.48 µM 1.56885235150512 0.0473644335603123 no 234 0.0583411733238589 420 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_98 0074-0023 107.663 µM 1.56415582332039 0.0478227062058008 no 235 0.0588904894545049 412 3563821 SGTC_2346 9031566 143.75 µM 1.55339442762777 0.0488861590020674 no 236 0.0601644666760447 360 4771086 SGTC_711 k292-0785 179 µM 1.54991383181919 0.04923413147443 no 237 0.0605810996499204 388 4146315 SGTC_2318 6029776 164 µM 1.5480665710164 0.0494196131573686 no 238 0.0608031347587846 413 818325 SGTC_1049 3226-0134 66 µM 1.54666388704905 0.0495608275642458 no 239 0.0609721577595575 436 5702385 SGTC_3318 9139014 38.6185 µM 1.54423912225839 0.0498056987024838 no 240 0.0612652072298734 365 16643984 SGTC_823 0417-1665 178 µM 1.53524627202015 0.0507223025745369 no 241 0.0623616730787789 399 3429856 SGTC_3282 9108498 15.4605 µM 1.53482848414166 0.0507652103474381 no 242 0.0624129820408731 419 16459645 SGTC_188 3229-0966 278.469 µM 1.53204620439778 0.0510516944863082 no 243 0.0627555166772416 476 5722370 SGTC_3225 9130819 49.47 µM 1.53137534086148 0.0511209637403511 no 244 0.0628383274608071 410 4547121 SGTC_1725 st036284 20.55 µM 1.52912342317503 0.051354029995244 no 245 0.0631169248254414 463 707914 SGTC_1129 3453-1384 223 µM 1.52459874247948 0.0518248747300075 no 246 0.0636796056275678 449 1084452 SGTC_179 1273-0063 6.77 µM 1.52177359277497 0.0521205995074661 no 247 0.0640329101977954 348 3108139 SGTC_1979 st071809 45.3 µM 1.52171281471745 0.0521269761963088 no 248 0.064040527628277 395 4976333 SGTC_1835 st008666 49.2 µM 1.52046110939094 0.052258439983884 no 249 0.0641975629785901 345 690455 SGTC_185 k048-0037 25.491 µM 1.51250292096178 0.053100439477989 no 250 0.0652029850602157 411 6827589 SGTC_147 4466-0538 29.23 µM 1.50762710616748 0.0536216061154352 no 251 0.0658249956196463 448 6742687 YHR072W ERG7 SGTC_446 go6976 132 µM 1.50282153370527 0.0541392213465228 no 252 0.0664425357230578 363 3501 A protein kinase C inhibitor. SGTC_2850 9015429 58.44 µM 1.50022032360729 0.0544210465360149 no 253 0.0667786702000151 390 6457570 SGTC_1980 st071811 45.7 µM 1.49945246647978 0.0545044606216174 no 254 0.0668781456197195 404 4974850 SGTC_825 1988-2224 89.6 µM 1.4968957623363 0.0547829303265478 no 255 0.0672101915259948 452 1180859 SGTC_2094 5332512 191.667 µM 1.49660942742795 0.054814187100083 no 256 0.0672474578262483 436 755774 SGTC_1667 st014849 34.6 µM 1.49592062833679 0.0548894352457351 no 257 0.0673371700118381 412 5348460 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.49563096833109 0.0549211036496018 no 258 0.0673749242105152 499 688664 SGTC_3303 9125618 40.5795 µM 1.49304175985592 0.055204822495621 no 259 0.0677131280288747 517 22695467 SGTC_346 4513-0042 7.16 µM 1.49201599830253 0.0553175424933458 no 260 0.0678474756848546 452 2827372 SGTC_2815 7968870 71.43 µM 1.4913183296426 0.0553943124612098 no 261 0.0679389694032419 471 2977326 YHR190W ERG9 SGTC_2556 citropten 84.59 µM 1.48653556066812 0.0559228655756527 no 262 0.0685687590337376 483 2775 A potential DNA crosslinker. SGTC_802 4112-3352 742 µM 1.48382749893529 0.0562238981101064 no 263 0.0689273449109379 479 704594 SGTC_2664 lyso-paf C-16 73.48 µM 1.47621031522169 0.0570774902786646 no 264 0.0699437206189186 447 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.47425472522309 0.0572982740144658 no 265 0.0702065101307065 457 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2201 6605497 169.863 µM 1.47271422019915 0.0574726679205106 no 266 0.0704140552827504 396 670741 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.46557132629136 0.058286746446941 no 267 0.0713825538153287 429 6312947 SGTC_1480 1070-0044 41.2 µM 1.45369748511105 0.0596600246912032 no 268 0.0730150978722967 442 3124987 SGTC_992 3909-8734 162 µM 1.44788484779387 0.0603414697098681 no 269 0.0738246289728589 443 4288319 SGTC_1638 st008370 60.6 µM 1.44772092382897 0.0603607753018252 no 270 0.0738475578599716 473 24207134 SGTC_795 0685-0265 78 µM 1.44745601902606 0.0603919837885988 no 271 0.0738846229592221 482 302754 SGTC_297 0986-0032 24 µM 1.44591656675014 0.0605735969427798 no 272 0.074100302333564 390 2847425 SGTC_767 0929-0023 86 µM 1.42409221871479 0.0631944808892593 no 273 0.0772098893114676 569 1204563 SGTC_1119 parthenolide 318.541 nM 1.42217526983872 0.0634288420308157 no 274 0.0774876880448107 547 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3284 9108171 64.8615 µM 1.41960899152653 0.0637436468508723 no 275 0.0778607731373154 425 8687505 SGTC_881 0833-0569 170 µM 1.4150667840653 0.0643038163302938 no 276 0.0785244579703608 480 5418700 SGTC_668 1682-0499 62.6 µM 1.39963864286871 0.0662350948681556 no 277 0.0808107780082409 554 682214 SGTC_372 0155-0182 15.9 µM 1.3990751560339 0.0663064727435482 no 278 0.0808952234430098 509 771486 SGTC_57 miconazole 162.5 nM 1.39758196889575 0.0664959054713054 no 279 0.0811193180476032 451 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2123 5259487 200 µM 1.38817178565052 0.0676993801862823 no 280 0.0825423707644196 508 2173474 SGTC_91 0417-1751 58.384 µM 1.38740187379015 0.0677985846037092 no 281 0.082659626976631 600 6795624 SGTC_2441 5730946 39.09 µM 1.3821112365298 0.0684833314387591 no 282 0.0834687744254799 497 1774275 SGTC_2685 mycophenolic acid 18.85 µM 1.38078855650222 0.0686553516590979 no 283 0.0836719915336494 435 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1965 Pectolinarigenin 58.4 µM 1.37934560477857 0.0688433935871545 no 284 0.083894110933489 481 5320438 An anti-inflammatory. SGTC_2235 salicylic acid 500 µM 1.37708531414092 0.0691387469305433 no 285 0.0842429363007572 455 338 A COX inhibitor and kinase inhibitor. SGTC_900 1112-0045 141 µM 1.37461941165042 0.0694620803172887 no 286 0.0846247336514117 378 56211 YIL048W NEO1 SGTC_2093 5331342 194.4 µM 1.37409837388776 0.0695305484740289 no 287 0.08470557210912 504 33839 SGTC_385 1494-0393 12.4 µM 1.36830489496949 0.0702953593172051 no 288 0.0856083296164571 509 3090647 SGTC_3250 9135583 49.47 µM 1.36722807409601 0.0704382232715764 no 289 0.0857769141445133 470 7699353 SGTC_1617 st002906 78 µM 1.36684799491963 0.0704887023921762 no 290 0.0858364777396782 528 5150859 SGTC_2531 methyl deoxycholate 70.07 µM 1.36160853737562 0.0711874029739783 no 291 0.0866607297496599 492 16667744 Haematoxylin. SGTC_197 4544-0043 41.561 µM 1.36080488179069 0.0712950421014461 no 292 0.0867876793851803 545 896523 SGTC_211 3455-0679 143.504 µM 1.35492746270433 0.0720860470307157 no 293 0.0877203344472353 527 748649 SGTC_1770 st043884 66.3 µM 1.35423940797738 0.0721790861775823 no 294 0.0878300050904073 507 670149 SGTC_1058 3448-5425 97.3 µM 1.3535764067646 0.072268824620971 no 295 0.0879357791166513 496 7279705 SGTC_1892 st058411 7.36 µM 1.35180669978148 0.0725087764399552 no 296 0.088218580159481 585 3934738 SGTC_914 3820-6779 408 µM 1.34910843068161 0.07287580455676 no 297 0.0886510703612438 488 2893481 SGTC_1696 st025591 34.7925 µM 1.34797781756857 0.0730300167117641 no 298 0.0888327586598967 533 2787147 SGTC_1476 4112-3294 3.34 µM 1.34748992528081 0.0730966408106691 no 299 0.0889112480015526 493 704369 SGTC_1096 rimcazole 32.2 µM 1.34499896700195 0.0734375185928323 no 300 0.0893127840801261 471 18528119 A dopamine reuptake inhibitor. SGTC_371 0195-0006 7.36 µM 1.34084416082656 0.0740087905665101 no 301 0.089985527453128 431 3928593 SGTC_3147 9097027 49.47 µM 1.33727549049176 0.0745021760447536 no 302 0.0905663641410622 549 25236841 SGTC_1750 st081859 2.357 µM 1.33722985606115 0.0745085014391229 no 303 0.0905738095798349 721 5291695 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.3370526037651 0.0745330742916252 no 304 0.0906027333065689 560 688664 SGTC_1243 0416-0003 5.65 µM 1.33692218165067 0.0745511589292358 no 305 0.0906240197422517 523 2141977 SGTC_832 4083-0019 164 µM 1.33505427903044 0.0748105343398087 no 306 0.0909292910125193 727 1990758 SGTC_1052 3253-3998 198 µM 1.33269071773989 0.0751397225925077 no 307 0.0913166603154758 572 5450317 SGTC_1913 st060213 96.1 µM 1.33230824013213 0.0751930963599569 no 308 0.0913794602575183 568 688959 SGTC_2881 9058953 51.95 µM 1.33033748363048 0.0754685686628052 no 309 0.0917035511696778 548 17122249 SGTC_1281 0884-0031 11.8 µM 1.32751518666833 0.0758644077464699 no 310 0.0921691598208231 546 1548255 SGTC_3196 9111891 49.47 µM 1.32155815798747 0.0767050943729369 no 311 0.0931576621277084 490 18891510 SGTC_1165 k072-0275 30.3 µM 1.31568475387631 0.0775408967946734 no 312 0.0941399367428716 506 6153523 YGL055W OLE1 SGTC_2920 7982904 15.77 µM 1.31385638956491 0.0778024847373006 no 313 0.0944472684880642 460 6456808 SGTC_13 0199-0087 65 µM 1.31245731887837 0.078003104679733 no 314 0.0946829389694079 553 4589825 SGTC_2566 crystal violet carbinol 226 nM 1.31077607797497 0.0782447053961544 no 315 0.0949667134392922 487 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_35 0133-0054 64.071 µM 1.30919236779877 0.0784728092735161 no 316 0.0952345984424111 513 99677 SGTC_2384 9036245 200 µM 1.30843537232583 0.0785820182491344 no 317 0.0953628407988996 553 6462766 SGTC_460 trequinsin 123 µM 1.30738439922085 0.0787338292440174 no 318 0.0955410965183499 558 5537 A vasodilator. SGTC_800 3448-7362 155 µM 1.30546742215491 0.0790113050210618 no 319 0.0958668666530614 821 15991913 SGTC_2580 diallyl disulphide 81.36 µM 1.30461428395893 0.0791350317100201 no 320 0.0960121109629137 516 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2478 5763493 32.33 µM 1.30264968114739 0.0794205068276848 no 321 0.0963471941359253 555 1365576 YLR208W SEC13 SGTC_1420 4'-methoxyflavone 42 µM 1.30189940805586 0.0795297339404506 no 322 0.0964753874320308 526 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2646 retinol 96.75 µM 1.30073315885554 0.0796997457889364 no 323 0.0966749040513606 513 445354 A vitamin A analog and teratogen. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.29828251670287 0.0800578877254089 no 324 0.0970951359511424 603 6708784 An antioxidant flavonoid SGTC_644 1498-1197 63.3 µM 1.29637771682334 0.0803370984975532 no 325 0.0974226926236911 585 6741615 SGTC_3079 9117512 49.47 µM 1.29286172122951 0.0808544144992112 no 326 0.0980294443636069 548 7185044 SGTC_2072 5231554 129 µM 1.2878305142774 0.0815990355843886 no 327 0.09890248386387 548 789545 SGTC_1440 4100-1550 40 µM 1.28613153287472 0.0818516499864513 no 328 0.0991985804316999 500 742806 SGTC_2015 5119600 184 µM 1.28591342648125 0.081884121951347 no 329 0.0992366386689642 561 2828786 SGTC_3341 9147222 25.867 µM 1.28561264528925 0.0819289185728139 no 330 0.0992891406677271 525 1939759 SGTC_2707 st078556 66.6 µM 1.28473481131694 0.0820597637170322 no 331 0.0994424845828211 541 17250899 SGTC_86 0417-1630 471.922 µM 1.28249721586795 0.0823939995292171 no 332 0.0998341404932275 690 3634867 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.2793064677483 0.0828723819891326 no 333 0.100394577956378 597 6708561 SGTC_2020 4017018 200 µM 1.27895605713115 0.0829250454297936 no 334 0.100456265297117 555 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2682 pyrogallin 40.03 µM 1.27356269059909 0.0837387967703813 no 335 0.101409220876965 614 822798 An ATP competetive kinase inhibitor. SGTC_214 4373-3496 70 µM 1.27219895271233 0.0839455046139071 no 336 0.101651219824373 735 3779166 SGTC_1846 st056244 14.8 µM 1.27143310785064 0.0840617550238496 no 337 0.101787305287435 597 5393182 SGTC_2821 7996764 71.43 µM 1.26756410819957 0.084650892979398 no 338 0.102476828081074 600 2987135 SGTC_3041 9091929 49.47 µM 1.26593421397861 0.0849000042425257 no 339 0.102768317938785 587 25236887 SGTC_141 0443-0274 32.331 µM 1.26447955798134 0.0851227960546378 no 340 0.103028976670716 689 1627241 SGTC_1788 fluconazole 20 µM 1.26184182858532 0.0855279017742426 no 341 0.103502853730127 553 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2059 5238311 157 µM 1.2603851998826 0.0857522304937498 no 342 0.10376521903026 574 703021 SGTC_1713 st033146 12.748 µM 1.26024948280724 0.0857731540690544 no 343 0.103789688689639 577 674619 SGTC_994 3910-0338 138 µM 1.25842161691783 0.0860553295968892 no 344 0.104119659078416 610 3479481 SGTC_959 1222-0044 107 µM 1.25730720329691 0.0862277068989245 no 345 0.104321208315611 575 6083612 SGTC_3122 9126309 49.47 µM 1.2563627267212 0.086374000450463 no 346 0.104492244529225 549 17591206 SGTC_418 lividomycin a 100 µM 1.25485942796869 0.086607234767191 no 347 0.10476489729711 612 72394 An antibiotic. SGTC_1865 st057639 52.2 µM 1.25420094955589 0.0867095447380774 no 348 0.104884487415765 574 688818 SGTC_1839 st053978 48 µM 1.2498910375769 0.087381421352698 no 349 0.105669676909148 570 3788398 SGTC_3051 9093778 49.47 µM 1.24552346957656 0.0880662427777775 no 350 0.106469696987686 497 17217378 SGTC_2903 5923464 63.88 µM 1.2447440454284 0.0881888737512634 no 351 0.106612924995275 561 2876576 SGTC_2835 9006588 71.43 µM 1.24248239568882 0.0885454317189912 no 352 0.107029315886459 577 2345538 SGTC_919 tnp00227 403.569 nM 1.24232649553783 0.0885700494984711 no 353 0.107058061719202 632 1269246 A methoxyflavone. YNL221C POP1 SGTC_951 1171-0579 82.7 µM 1.24150946672502 0.0886991477323423 no 354 0.107208801599872 669 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2628 lathosterol 100 µM 1.23325536167145 0.0900112420786941 no 355 0.108740253154033 602 6710616 SGTC_2888 9058547 12.99 µM 1.23232231139215 0.0901604647918339 no 356 0.108914354297952 500 16476514 SGTC_2320 7373003 200 µM 1.22866628820576 0.0907469435212515 no 357 0.109598475376085 566 5415828 SGTC_2160 5660466 132.927 µM 1.22478763322731 0.0913722254948221 no 358 0.110327622831722 587 2859134 SGTC_1720 st037298 9.481 µM 1.2226552911192 0.0917173402814694 no 359 0.11072996009024 557 597396 SGTC_544 k015-0020 52.4 µM 1.22228632577328 0.0917771543731991 no 360 0.110799684241238 581 3008304 SGTC_1332 1480-0653 17.5 µM 1.21523759722403 0.0929254003155234 no 361 0.112137742316317 605 5749438 SGTC_921 1561-0023 372 µM 1.21281420864165 0.0933226164584522 no 362 0.112600430897355 621 24050882 SGTC_1755 st041960 45.185 µM 1.20978297193259 0.093821228677284 no 363 0.113181090950007 602 2257073 SGTC_480 am 92016 50 µM 1.20961291208987 0.0938492601946421 no 364 0.113213730583558 553 2129 K+ channel blocker. SGTC_221 trifluoperazine 10.304 µM 1.20809863357892 0.0940991362900221 no 365 0.113504662636606 762 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2728 chlorpromazine 9.18 µM 1.2064818431118 0.0943664696770297 no 366 0.113815877927625 511 2726 A thorazine and dopamine antagonist. SGTC_772 k072-0172 35.3 µM 1.2040212821805 0.0947743931511859 no 367 0.114290676445016 568 5861980 SGTC_2155 5570423 76 µM 1.20166054689924 0.095166987096993 no 368 0.114747536375954 604 797402 SGTC_2863 9028737 58.44 µM 1.20157384236352 0.0951814289627758 no 369 0.114764340523324 583 6460917 SGTC_1154 4088-0362 150 µM 1.19908944559761 0.0955959262712074 no 370 0.115246583800577 689 6618304 SGTC_2057 5236571 38.335 µM 1.19594756094513 0.0961220191393197 no 371 0.115858511703036 653 54684039 YBR257W POP4 SGTC_2778 tioconazole 65.09 nM 1.19229519482412 0.0967362613589024 no 372 0.11657275900228 647 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1207 2099-0101 141 µM 1.18494344313326 0.0979813851884631 no 373 0.118019904601243 682 5837381 SGTC_3052 9092717 49.47 µM 1.18328113170305 0.0982645421443189 no 374 0.118348874054478 594 25237534 SGTC_1935 st074532 41.6 µM 1.17859198110149 0.0990665179176518 no 375 0.119280343128996 735 2829742 SGTC_2703 st077852 53.4 µM 1.17792717415636 0.0991806048540391 no 376 0.119412820301586 610 6281836 SGTC_400 oxethazaine 37.5 µM 1.16703973431727 0.101062678801346 no 377 0.121597161798579 619 4621 A local anesthetic. SGTC_851 0394-0702 453 µM 1.16644440781911 0.101166336377927 no 378 0.121717406390384 703 762646 SGTC_2991 9074669 71.4286 µM 1.16330605050847 0.101714064589145 no 379 0.122352675850836 716 17333109 SGTC_2936 9038235 15.59 µM 1.16291548722849 0.101782379215551 no 380 0.122431896591647 634 4749415 SGTC_1511 0906-3109 28.5 µM 1.16125165720083 0.102073779084914 no 381 0.122769786410339 749 2882180 SGTC_1242 0402-0103 60.1 µM 1.15811563881503 0.10262466443706 no 382 0.123408424402023 610 432868 SGTC_1978 st071761 42 µM 1.15280644801884 0.103562218616223 no 383 0.124494918599497 619 5147680 SGTC_1065 prochlorperazine maleate 2.48 µM 1.15131928473152 0.103825948918732 no 384 0.124800453136582 675 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1483 3453-0561 55.9 µM 1.15116922570362 0.103852587093773 no 385 0.124831311522296 703 4546991 SGTC_482 fipronil 114 µM 1.14897328907315 0.104242972517549 no 386 0.125283497490142 602 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3307 9126885 69.2785 µM 1.14869038579133 0.104293343248561 no 387 0.125341835815047 683 24824909 SGTC_379 3970-0972 5.9 µM 1.14247986349439 0.105403570059598 no 388 0.126627305709461 656 2898042 YBL034C STU1 SGTC_33 0986-0033 35.816 µM 1.14196485525946 0.105496018146928 no 389 0.126734314223497 624 2848082 SGTC_631 k072-0230 41.5 µM 1.14188094084335 0.10551108700853 no 390 0.126751755941763 715 5773147 SGTC_1668 st014914 51.6 µM 1.13906105582505 0.106018370928764 no 391 0.127338844636539 658 2839556 SGTC_2780 5215298 71.43 µM 1.13805092482832 0.106200516728091 no 392 0.127549609244574 717 2834131 SGTC_997 3996-0078 137 µM 1.13751960653517 0.106296414174128 no 393 0.12766056650419 685 735687 SGTC_2882 9058044 58.44 µM 1.13520816094587 0.106714334002054 no 394 0.128144055472122 640 18076804 SGTC_392 N-ethylmaleimide 8.33 µM 1.13444011461168 0.106853462384153 no 395 0.128304990161127 644 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1063 disulfiram 1.84 µM 1.13313963720837 0.107089336749379 no 396 0.128577809129282 660 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2489 cantharidin 73.42 µM 1.1316503215685 0.107359922690376 no 397 0.128890737491467 677 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3199 9111318 49.47 µM 1.1297330842429 0.107708980622893 no 398 0.129294356014453 685 8548020 SGTC_1142 3253-1408 9.78 µM 1.1280232367519 0.108020969618545 no 399 0.129655052919896 657 256655 SGTC_2776 terbinafine 19.92 µM 1.1267844875375 0.108247405319871 no 400 0.129916805367699 650 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_786 4544-0069 423 µM 1.12479534108545 0.108611723390075 no 401 0.130337884573144 708 748821 YLR208W SEC13 SGTC_1375 2910-0797 186 µM 1.12407808472453 0.108743307119586 no 402 0.130489950755316 680 742508 SGTC_1766 st045414 44.774 µM 1.12302623939946 0.108936479879627 no 403 0.130713175279877 731 253960 SGTC_679 0422-0091 41.4 µM 1.11589201332165 0.110253202588569 no 404 0.132234180450196 725 627384 YHR062C RPP1 SGTC_1474 0330-0125 5.35 µM 1.1154404288439 0.110336931386374 no 405 0.132330866426617 696 X1474 SGTC_606 k015-0008 38.6 µM 1.11441899585899 0.110526484633809 no 406 0.13254973887948 766 1970475 SGTC_1888 azatryptophan 97.5 µM 1.11393292975248 0.110616768669487 no 407 0.132653980561363 624 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_496 calpeptin 138 µM 1.10914474126976 0.11150897364402 no 408 0.133683873190163 596 73364 A calpain inhibitor. SGTC_1820 st053765 18.6 µM 1.10867168824526 0.111597398487582 no 409 0.13378591985829 661 3690829 SGTC_2732 terfenadine 20 µM 1.10855332069557 0.111619532038593 no 410 0.133811462396713 646 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1686 st019653 115.5 µM 1.10812854232976 0.111698987214489 no 411 0.133903152935568 698 97252 SGTC_721 1187-1332 279 µM 1.10751080041967 0.111814608586978 no 412 0.13403657266339 626 25730 SGTC_2173 5763948 167 µM 1.10505974110104 0.112274211440342 no 413 0.134566851809002 719 2867177 SGTC_2295 7971645 200 µM 1.10481378245492 0.112320406045792 no 414 0.13462014359765 697 2978226 YKL099C UTP11 SGTC_409 arachidonic acid 100 µM 1.10356975330492 0.112554260856621 no 415 0.13488990893396 704 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1759 st043059 70 µM 1.10295897467655 0.112669203312005 no 416 0.13502249074874 728 669426 SGTC_1955 wogonin 32.4 µM 1.09621568780534 0.113943797007453 no 417 0.136492197931937 685 5281703 A flavanone. SGTC_526 4469-0568 170 µM 1.09614038947585 0.113958087413695 no 418 0.136508670826402 688 2901964 SGTC_1953 st076800 12.1 µM 1.09230516077711 0.114687641483144 no 419 0.137349496365249 711 297591 SGTC_313 3474-0040 5.03 µM 1.08859692222254 0.11539619326564 no 420 0.138165837314694 739 1043375 YIL048W NEO1 SGTC_1147 3809-1045 12.3 µM 1.08822347216828 0.1154677222959 no 421 0.138248232529401 697 325925 SGTC_2286 7945697 125 µM 1.08817971923992 0.115476104606508 no 422 0.138257888038609 689 1245733 SGTC_2241 6772625 37.8075 µM 1.0867458665715 0.115751045492314 no 423 0.138574568764869 679 2285411 SGTC_3350 9150499 3.57 µM 1.08300488518681 0.116470565712818 no 424 0.139403127342578 782 4910996 YPR165W RHO1 SGTC_779 1360-0071 233 µM 1.08169790917667 0.116722688679282 no 425 0.139693391258507 787 7566 SGTC_206 4546-0025 72.014 µM 1.08158140417835 0.116745181913069 no 426 0.139719285574103 795 6620745 YIL048W NEO1 SGTC_472 calcifediol 10 µM 1.08018086146963 0.117015820593129 no 427 0.140030824582653 662 5283731 A vitamin D metabolite. SGTC_1478 0453-0656 35.7 µM 1.07961883933606 0.117124549774488 no 428 0.140155974312373 729 5258496 SGTC_448 monastrol 171 µM 1.07767896986897 0.117500388069373 no 429 0.140588523361149 717 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_879 0831-1030 162 µM 1.07585747102333 0.117854069325754 no 430 0.140995502354719 763 1549252 SGTC_1094 duloxetine 25.4 µM 1.0745529666534 0.118107828008274 no 431 0.141287459433508 719 60834 A selective serotonin reuptake inhibitor. SGTC_1318 1280-3875 124 µM 1.07380375737343 0.118253742503466 no 432 0.141455322782688 750 373245 SGTC_2854 9024559 71.43 µM 1.07021891914982 0.118953682322973 no 433 0.142260390196771 680 3163529 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.07021135016485 0.118955163256121 no 434 0.142262093279915 738 5282309 SGTC_1382 3002-2117 298 µM 1.06980932193898 0.119033842043556 no 435 0.142352572725825 779 1497314 SGTC_2191 5911152 200 µM 1.06902044121837 0.119188336430528 no 436 0.142530229331875 733 2875902 SGTC_2300 7976697 71.57 µM 1.067196041206 0.119546168923916 no 437 0.142941659921943 621 2236109 SGTC_87 0100-0052 35.5 µM 1.0640100958729 0.120172866839215 no 438 0.143662063014491 947 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_492 tmb-8 126 µM 1.05968614371151 0.121027116417934 no 439 0.144643704314389 577 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1616 st002734 56.1 µM 1.05636475229531 0.121686192715324 no 440 0.145400801534053 777 4026101 SGTC_126 0417-1624 672.48 µM 1.05621625087242 0.121715719205934 no 441 0.145434713949847 885 41912 YDL195W SEC31 SGTC_930 2810-3379 265 µM 1.05611819154051 0.121735219071146 no 442 0.145457110111523 827 1015764 SGTC_1966 st070145 16.1 µM 1.05332029314672 0.122292528117999 no 443 0.146097110641266 731 3748532 SGTC_3170 9103054 49.47 µM 1.05011341023417 0.122933502011324 no 444 0.146832986940759 695 16432970 SGTC_219 mitoxanthrone 164.414 µM 1.04673938910376 0.12361042148255 no 445 0.147609895828497 721 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1409 3909-8004 61.9 µM 1.04628585881654 0.123701610495931 no 446 0.147714536173459 780 2119279 SGTC_1122 capsaicin 818.572 nM 1.04373716669703 0.124214939046719 no 447 0.148303504597678 776 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1704 st028805 70.8 µM 1.04219580425507 0.1245261048279 no 448 0.148660453962837 744 2876101 SGTC_902 1120-0002 2.07 µM 1.04145546702909 0.124675755537312 no 449 0.148832105578842 777 3280475 SGTC_1426 4048-4480 71.7 µM 1.04070967841995 0.124826635226904 no 450 0.149005154995893 786 14224343 SGTC_2289 7946404 165.07 µM 1.04034570151186 0.124900317312031 no 451 0.149089659341199 812 1246120 YPR165W RHO1 SGTC_2061 5245884 80.95 µM 1.03745170298438 0.125487248597526 no 452 0.149762696563458 766 573863 SGTC_2023 5144124 124 µM 1.03518034318491 0.125949248900891 no 453 0.150292348461477 759 2830192 SGTC_1507 4075-3230 155 µM 1.03405400673268 0.126178787953497 no 454 0.150555458064862 692 659771 SGTC_3034 9090421 49.47 µM 1.02926687026899 0.12715762356568 no 455 0.151677143397056 740 17173761 SGTC_27 0485-0001 32.618 µM 1.02776332266954 0.127466144459208 no 456 0.152030586486759 709 2054479 SGTC_143 4032-1194 15.74 µM 1.02242467885328 0.12856581288925 no 457 0.153289972518322 855 1806963 SGTC_3138 9097216 49.47 µM 1.02110974105149 0.128837674942638 no 458 0.153601224246075 804 25237486 SGTC_209 4077-0173 175.592 µM 1.01954031536038 0.129162673785226 no 459 0.153973261844051 662 15993494 SGTC_3351 9150312 21.596 µM 1.01936316321649 0.129199394362078 no 460 0.154015293770196 770 4904905 SGTC_596 1155-0152 116 µM 1.01648617346186 0.129796757830492 no 461 0.154698964195041 814 280313 SGTC_96 0929-0093 37.281 µM 1.01618998601102 0.129858365087964 no 462 0.154769462062074 753 6991579 SGTC_935 2996-0153 430 µM 1.01501494399466 0.130102974360048 no 463 0.155049352006332 790 23738523 SGTC_1467 k284-1082 293 µM 1.01446948832698 0.13021663052612 no 464 0.155179390708789 825 3334705 SGTC_646 4092-0839 27.3 µM 1.01426083675352 0.130260125250215 no 465 0.155229153068718 809 877796 SGTC_2365 9042475 200 µM 1.01202268325342 0.130727314551758 no 466 0.155763603952301 768 6464479 SGTC_740 k014-0057 261 µM 1.01044213421977 0.131057933345109 no 467 0.156141754931681 860 4012779 SGTC_2523 spermine 47.74 µM 1.00790155990845 0.131590579630784 no 468 0.156750861355726 776 1103 A DNA binding polyamine. SGTC_1604 st002052 72.4 µM 1.00204394014791 0.132824351809116 no 469 0.15816118569214 792 6254834 YHR062C RPP1 SGTC_710 3448-4187 58 µM 1.00131678934438 0.13297806329692 no 470 0.158336839240352 880 3946412 SGTC_1521 st012942 49.4 µM 0.999175826622288 0.133431349589621 no 471 0.158854761941512 856 24207259 SGTC_1201 1889-3372 45.9 µM 0.997321026096519 0.133824907697267 no 472 0.1593043554868 786 5392199 SGTC_1484 3473-2379 286 µM 0.996826480108182 0.133929976801531 no 473 0.159424371308138 937 671917 SGTC_2192 5915882 198.485 µM 0.996663122797996 0.133964695442245 no 474 0.159464027664853 774 2876149 SGTC_1749 st037932 54.2 µM 0.99652436896925 0.133994189915294 no 475 0.159497716391699 757 594497 SGTC_2943 9068529 45.32 µM 0.995155356361566 0.13428543589971 no 476 0.159830355447221 891 3270634 SGTC_1849 st056239 19.2 µM 0.994643117942242 0.134394522025831 no 477 0.159954934365898 791 5393181 SGTC_1722 st034304 3.6505 µM 0.993641185643459 0.134608069063618 no 478 0.160198792800435 797 4036148 YLR033W RSC58 SGTC_2210 7115885 190.385 µM 0.993569485570829 0.134623359797193 no 479 0.160216253060512 834 2927039 SGTC_1845 st056753 3.01 µM 0.992540905054795 0.134842845757728 no 480 0.160466867872462 806 5375839 SGTC_2451 5856223 45.7 µM 0.991822475195951 0.134996295070065 no 481 0.160642065965237 783 2179896 SGTC_1355 1499-0035 1.68 µM 0.990775975041029 0.135220031083585 no 482 0.160897491541116 788 1548538 SGTC_1822 st052468 42 µM 0.988798868854442 0.135643419096495 no 483 0.161380778901541 782 2873678 SGTC_1152 3909-8331 15.9 µM 0.988566574076824 0.13569322348632 no 484 0.161437623537599 782 16001939 SGTC_2833 9001315 45.46 µM 0.985399382503791 0.13637352442364 no 485 0.162213966427764 806 2989378 SGTC_2870 9038528 12.99 µM 0.984109067381977 0.136651347104377 no 486 0.162530944554583 714 6463316 SGTC_2048 5246248 200 µM 0.982204006574647 0.137062240094141 no 487 0.162999677072065 808 677046 SGTC_1053 3366-3204 134 µM 0.98011674147823 0.137513400018856 no 488 0.163514248071119 796 3632071 YPR165W RHO1 SGTC_2755 lomerizine 42.69 µM 0.979719387505138 0.137599402358002 no 489 0.163612326677519 829 3949 A calcium channel blocker. SGTC_1844 rapamycin 4 nM 0.978981604708639 0.137759183643158 no 490 0.16379453437591 894 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3128 9127691 49.47 µM 0.974853838671906 0.138655467307296 no 491 0.164816383309483 717 41316314 SGTC_1746 st038117 42 µM 0.970765714562914 0.139547050633078 no 492 0.165832479693163 805 2898218 SGTC_952 1185-0122 232 µM 0.96817263352937 0.140114595039669 no 493 0.16647907993944 817 678600 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.96613696733613 0.140561236033898 no 494 0.166987824306016 888 66535 A nucleotide analog. SGTC_2238 6671620 73.2395 µM 0.965857568111641 0.140622613739453 no 495 0.167057728648892 805 729941 SGTC_2534 helenine 20.12 µM 0.965576044137588 0.140684476600734 no 496 0.167128183676576 781 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_486 niguldipine 82 µM 0.960033152510953 0.141906249085095 no 497 0.168519264957821 809 1236 A calcium channel blocker. SGTC_2604 4'-hydroxychalcone 11.32 µM 0.95940907709374 0.142044257343168 no 498 0.168676352049938 792 5282362 SGTC_317 4495-0002 170 µM 0.958675733284394 0.142206545324296 no 499 0.168861063510257 793 15991618 SGTC_751 0833-0568 350 µM 0.957720748188174 0.142418070239423 no 500 0.169101795746702 843 6954252 SGTC_747 3448-8087 38.7 µM 0.957352392957211 0.142499716120717 no 501 0.169194709446059 852 5168703 SGTC_3114 9122766 49.47 µM 0.956095206007541 0.142778609781233 no 502 0.169512068302029 771 17176985 SGTC_582 0987-0078 156 µM 0.95520256287248 0.142976857099521 no 503 0.169737635011642 956 1625765 SGTC_3165 9101544 49.47 µM 0.95409220777422 0.143223715590195 no 504 0.170018485033998 851 5002184 SGTC_749 1000-0129 128 µM 0.952681615147487 0.143537738995278 no 505 0.170375705575907 898 708470 SGTC_614 0462-0418 107 µM 0.951798380670184 0.143734599381961 no 506 0.170599621729735 776 5188303 SGTC_2348 9022543 33.42 µM 0.951041434865963 0.143903456726991 no 507 0.170791671239495 865 3162678 YDL140C RPO21 SGTC_841 0251-0215 91.2 µM 0.950730237532791 0.143972916554008 no 508 0.170870667202696 897 3888614 SGTC_2845 9003024 42.97 µM 0.948596588245786 0.144449760030659 no 509 0.171412913446315 877 2990173 SGTC_1495 4469-0029 237 µM 0.941622102610939 0.146015887335006 no 510 0.173193074774246 941 793680 SGTC_2423 st077119 87.2 µM 0.941317263735988 0.146084598420558 no 511 0.173271149176131 832 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3156 9099931 49.47 µM 0.940588515159068 0.146248947331356 no 512 0.173457884844564 912 18111053 SGTC_1013 4112-3890 241 µM 0.939874779723433 0.146410030761924 no 513 0.173640897635139 839 705171 SGTC_516 3992-2719 87.3 µM 0.939431704209561 0.146510088674355 no 514 0.173754570824798 830 5350887 YDR037W KRS1 SGTC_1518 st038567 90.8 µM 0.938115564800065 0.146807577615643 no 515 0.174092511894521 867 77966 SGTC_1767 st044992 70.3 µM 0.938088413929626 0.146813718830105 no 516 0.174099487735576 845 9600693 SGTC_1380 2291-0730 164 µM 0.938013976333246 0.146830556641764 no 517 0.174118613810557 799 2999191 SGTC_549 1661-1316 519 µM 0.934489533587964 0.147629269701389 no 518 0.17502571621189 911 2857282 SGTC_1588 farnesol 29.9 µM 0.933126347014431 0.147938975550746 no 519 0.175377368591248 854 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1608 st001473 40.5 µM 0.93231628135824 0.148123222315401 no 520 0.175586547987629 831 7292267 SGTC_2914 7968218 45.32 µM 0.931233190177375 0.148369807643276 no 521 0.175866476376818 831 2977111 SGTC_3212 9128307 49.47 µM 0.920599804619637 0.150805266027663 no 522 0.178629702126111 760 27243542 SGTC_1365 1672-3266 55.4 µM 0.914744216623891 0.152157723777574 no 523 0.180162962911709 917 6415873 SGTC_3073 9114972 49.47 µM 0.914237868659728 0.152275051491452 no 524 0.18029593491981 822 41905075 SGTC_1475 4092-1048 11.7 µM 0.913650010529148 0.152411341541835 no 525 0.180450389542099 910 2881759 SGTC_1315 1237-0019 3.69 µM 0.912859526428903 0.152594736337947 no 526 0.180658213189139 928 825140 SGTC_401 neomycin 50 µM 0.908830451829956 0.153531768428511 no 527 0.181719814857927 868 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_581 0958-0271 211 µM 0.90706675166497 0.153943144506859 no 528 0.182185749494743 965 4591145 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.906991671684736 0.153960672785748 no 529 0.182205600693971 923 6728940 SGTC_730 1436-0052 41.2 µM 0.902710640462619 0.154962312954957 no 530 0.183339743854722 896 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3113 9123498 49.47 µM 0.901718563398581 0.155195043760069 no 531 0.183603194660441 949 8897275 SGTC_889 0919-1524 82.7 µM 0.900800305271247 0.155410662935224 no 532 0.183847252614022 855 3905452 SGTC_2651 TUB2.036 5 µM 0.90073717121447 0.155425494907325 no 533 0.183864040031697 1057 15992207 YFL037W TUB2 SGTC_893 0958-0369 48.9 µM 0.900551628782343 0.155469089467918 no 534 0.183913381501473 932 6819948 SGTC_1003 4049-0218 100 µM 0.899674176339314 0.155675362659186 no 535 0.184146834928196 927 295161 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.899045502584906 0.15582326341917 no 536 0.184314212112106 866 2346 DNA damaging agent; causes G2/M arrest. SGTC_1549 4'-methoxyflavonol 74.6 µM 0.899043464570494 0.155823743029712 no 537 0.184314754863979 905 97141 SGTC_2514 salinomycin 42.74 µM 0.898899076288313 0.155857724727916 no 538 0.184353210023277 987 23682228 A polyether potassium ionophore. SGTC_1761 st044296 37 µM 0.898288888335267 0.15600138605439 no 539 0.184515777461599 920 1826700 SGTC_56 0957-0365 83.25 µM 0.897505696352729 0.156185906935735 no 540 0.184724567582753 899 6752360 SGTC_615 k087-0205 167 µM 0.897370539214361 0.156217764647292 no 541 0.184760613801477 863 9642773 SGTC_2170 morpholine 200 µM 0.89720574824478 0.156256613101776 no 542 0.184804569236483 917 121171 Reacts with secondary amines. SGTC_3049 9092223 49.47 µM 0.896874172501694 0.156334799321776 no 543 0.184893031617652 879 8623917 SGTC_300 r073-0011 5.04 µM 0.896856969707738 0.156338856477834 no 544 0.184897621935871 984 2735780 SGTC_2883 9059145 45.46 µM 0.895343535512976 0.156696060549 no 545 0.185301737248808 878 16476510 SGTC_174 3553-0389 74.3 µM 0.893754935640425 0.15707158280378 no 546 0.185726512667361 857 738071 SGTC_2378 9074213 121.43 µM 0.891946458217382 0.157499800834351 no 547 0.186210815705751 937 657714 SGTC_3108 9121785 49.47 µM 0.890727065229532 0.157788965893703 no 548 0.186537805612963 916 17140271 SGTC_467 ro 31-8220 72.8 µM 0.8906137951153 0.157815844290196 no 549 0.186568197932109 913 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1623 st003709 20.3 µM 0.889968211245962 0.157969095320059 no 550 0.186741477719993 944 16192618 SGTC_3285 9112818 20.8695 µM 0.889308447829704 0.158125813259412 no 551 0.186918666301007 962 17017947 YPR165W RHO1 SGTC_2176 5809774 33.9695 µM 0.889299595126736 0.158127916793711 no 552 0.186921044523788 958 2870539 SGTC_1995 st072814 61.1 µM 0.889051947858982 0.158186768922634 no 553 0.186987580986991 881 5769371 SGTC_771 0250-0039 27.3 µM 0.887823730660302 0.158478860979429 no 554 0.187317787917932 891 3005115 SGTC_2146 5545642 200 µM 0.885829952043562 0.158953770019578 no 555 0.187854583538817 961 825326 SGTC_2779 methotrexate 400 µM 0.884980664741592 0.159156349351401 no 556 0.188083529891818 1003 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1613 st002381 52.1 µM 0.883813725032857 0.159434973577644 no 557 0.188398388042705 988 551167 SGTC_306 1672-3436 11.6 µM 0.88357768175295 0.159491371230129 no 558 0.188462115632897 948 6797378 SGTC_1377 2944-0135 198 µM 0.88163877695728 0.159955126514091 no 559 0.188986089254837 952 1894137 SGTC_2212 7123476 200 µM 0.881050805957019 0.160095933948855 no 560 0.189145160911298 874 1085715 SGTC_1189 1431-2119 7.28 µM 0.880566387430655 0.160212003484024 no 561 0.189276279061879 963 3107275 SGTC_3291 9121177 71.43 µM 0.880051563307406 0.160335418658666 no 562 0.189415688451344 834 17015612 SGTC_3230 9131665 49.47 µM 0.878812225258223 0.160632771210349 no 563 0.189751548284167 871 15943720 SGTC_2405 ticlatone 3.52 µM 0.878297192535445 0.16075644812531 no 564 0.189891229488484 975 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_456 gingerol 170 µM 0.8768922474221 0.161094139408496 no 565 0.19027258373247 993 442793 A herb. SGTC_2786 7743617 45.45 µM 0.876582762014065 0.161168589198583 no 566 0.190356652748752 841 583674 SGTC_3047 9092122 49.47 µM 0.876005491901321 0.161307517238093 no 567 0.190513524100696 903 17173831 SGTC_2946 9065502 71.43 µM 0.875689596254912 0.16138357495428 no 568 0.190599401349037 778 16489101 SGTC_584 0986-0246 15.4 µM 0.875654091451694 0.161392124853769 no 569 0.190609054929385 1052 53315 YDR232W HEM1 SGTC_339 3091-4833 71.4 µM 0.874349706997055 0.161706437999083 no 570 0.190963918644459 925 3240077 SGTC_1847 st056231 15 µM 0.874227554753514 0.161735893031569 no 571 0.190997171456169 1008 5393180 SGTC_205 1486-1330 71.903 µM 0.870147722840289 0.162721686808306 no 572 0.192109840254107 918 4118834 SGTC_2679 rapamycin 1 nM 0.869788787634858 0.162808601564164 no 573 0.192207920008581 1004 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1352 1496-0991 99 µM 0.862760168491071 0.164516636435722 no 574 0.194134671617236 958 3000039 SGTC_580 1123-0028 41 µM 0.861508716065497 0.164821967333983 no 575 0.194478961383981 1093 1677248 YPR107C YTH1 SGTC_2266 7929956 200 µM 0.860469318867687 0.165075839579199 no 576 0.1947651945137 960 2967153 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.858653773303584 0.165519892624996 no 577 0.195265780654275 1040 65057 A dermal irritant. YDR527W RBA50 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.855019380327871 0.166411125399614 no 578 0.196270209395837 914 4620898 SGTC_680 0417-1641 114 µM 0.854994747223801 0.166417176528364 no 579 0.196277027859379 902 2835990 SGTC_2368 9071271 200 µM 0.854220510542745 0.166607440384441 no 580 0.196491410396677 931 27209959 SGTC_1633 st005664 67.9 µM 0.854023354380285 0.166655912705467 no 581 0.196546024679908 998 2063822 SGTC_1224 0823-0416 294 µM 0.85394955674295 0.166674058748631 no 582 0.196566469749348 989 3598164 SGTC_1764 st044502 93.5 µM 0.853165653710009 0.166866890751512 no 583 0.196783723601921 958 8407 SGTC_2781 5567276 71.43 µM 0.853012958698879 0.166904468877846 no 584 0.196826058989623 936 2853274 SGTC_2082 5219693 150 µM 0.852987765006446 0.166910669550999 no 585 0.196833044585666 999 2834649 SGTC_3130 9127414 49.47 µM 0.852521566783051 0.167025437100434 no 586 0.196962337065049 969 1494646 SGTC_2502 avocadyne acetate 18.59 µM 0.851843549821189 0.167192440475414 no 587 0.197150465747601 1050 3952079 SGTC_1848 st056003 16.4 µM 0.849990980994977 0.16764929815095 no 588 0.197665050279387 1055 146492 SGTC_2259 7964009 200 µM 0.848861787893943 0.167928159846707 no 589 0.197979101924561 914 313134 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.848557892640309 0.168003259748237 no 590 0.19806367283429 904 521171 SGTC_3124 9127567 49.47 µM 0.84716506485811 0.168347737852965 no 591 0.198451561453983 942 17592030 SGTC_119 0121-0043 24.815 µM 0.845157566239733 0.168845036715083 no 592 0.199011435416089 1113 1092378 SGTC_2572 astragaloside iv 100 µM 0.843099420843131 0.169355860666397 no 593 0.199586421318311 958 45006101 An anti-inflammatory agent. SGTC_1734 st037168 69.4 µM 0.842614689301117 0.169476313383428 no 594 0.199721986513834 938 708907 SGTC_2589 lobaric acid 100 µM 0.842449543105502 0.169517363718778 no 595 0.199768185709989 957 73157 A novel microtubule depolymerizer. SGTC_1550 gossypolone 36.6 µM 0.842288558474183 0.169557385755646 no 596 0.199813226907014 1024 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_412 gemfibrozil 100 µM 0.841514894961356 0.169749809113423 no 597 0.200029772094083 954 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2576 guaiol 23.12 µM 0.841209802823075 0.169825729238515 no 598 0.20011520488437 1013 227829 SGTC_1028 k015-0029 4.8 µM 0.840990275197345 0.169880370678217 no 599 0.200176691216636 1031 4588309 SGTC_3031 9088762 49.47 µM 0.840491289817559 0.170004612367658 no 600 0.200316491621856 1028 205253 SGTC_335 4077-0256 27.6 µM 0.83987683824004 0.17015768382635 no 601 0.200488722683604 1061 3121989 SGTC_947 3447-0010 211 µM 0.838868870883073 0.170408978684482 no 602 0.200771448936132 1005 748350 SGTC_2028 5153890 36.43 µM 0.838226656266278 0.170569212167415 no 603 0.200951709400224 962 2830968 YPR165W RHO1 SGTC_2473 5854593 8.94 µM 0.837554407182464 0.170737042596687 no 604 0.201140504089012 943 2872951 SGTC_2452 5863136 48.41 µM 0.835837865555432 0.171166065329589 no 605 0.201623060622313 1001 2184096 SGTC_2017 5132927 60.65 µM 0.835155651594174 0.171336765312171 no 606 0.201815037968982 1018 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1186 1319-0216 26 µM 0.834255964147307 0.171562046693753 no 607 0.202068380382162 1043 4565136 SGTC_2862 9027634 71.43 µM 0.831882872731834 0.172157175393888 no 608 0.202737530111586 914 5012562 SGTC_3142 9086498 49.47 µM 0.830333845805849 0.172546353332275 no 609 0.203175028536912 944 25236367 SGTC_2959 9079155 11 µM 0.828960550619123 0.172891849161729 no 610 0.203563365172978 955 16189457 SGTC_2553 4-methylesculetin 85.09 µM 0.828506191929365 0.173006254444671 no 611 0.203691944869106 1042 5319502 SGTC_377 3970-0964 33.1 µM 0.828332705890232 0.173049950096405 no 612 0.203741052734082 1065 16481235 SGTC_2234 tolnaftate 200 µM 0.827914698479859 0.173155261829387 no 613 0.203859405084065 991 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1902 st060212 70.5 µM 0.827723342446565 0.173203485202731 no 614 0.203913598262562 1057 688944 SGTC_689 0833-0039 98 µM 0.827235123875072 0.173326559242694 no 615 0.204051903584769 1018 5374726 SGTC_1898 st060199 18.6 µM 0.823837844029328 0.174184513851409 no 616 0.205015850682753 1024 688866 SGTC_3302 9125395 16.351 µM 0.821019415313474 0.174898329216393 no 617 0.205817604620433 981 17599668 SGTC_583 1488-1091 88.9 µM 0.819591216110054 0.175260752816478 no 618 0.206224591384773 1156 4303273 SGTC_2653 dihydrofissinolide 100 µM 0.818441831994588 0.175552769167219 no 619 0.206552471795831 1031 6857746 SGTC_74 000s-0487 160.283 µM 0.817873239850957 0.175697341512854 no 620 0.206714785996584 1049 677548 SGTC_1106 tegaserod maleate 11.7 µM 0.816629241966111 0.176013907990312 no 621 0.207070169402383 1022 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2853 9015042 58.44 µM 0.816501794377253 0.176046360609472 no 622 0.207106598835723 1000 6457456 SGTC_1570 verbenone 133 µM 0.814894925340744 0.176455850664467 no 623 0.207566229098832 1027 29025 A natural terpanoid with antifungal properties. SGTC_836 0330-0104 1.35 µM 0.813448954832732 0.176824852390583 no 624 0.20798035062423 1051 46494820 SGTC_575 k072-0246 11.9 µM 0.813051610291232 0.176926337354137 no 625 0.208094234263682 1032 6796779 SGTC_1797 st048695 56.8 µM 0.812452966551357 0.177079305225627 no 626 0.208265882111838 1022 592262 YIL048W NEO1 SGTC_3016 9080866 49.47 µM 0.811925279214718 0.177214211291952 no 627 0.208417254026568 1061 17066299 SGTC_1071 trifluoperazine 6.31 µM 0.810576309132958 0.177559377623888 no 628 0.208804513209896 1051 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3277 9138724 49.47 µM 0.809269045076964 0.177894277006479 no 629 0.209180203758764 912 15943418 SGTC_2866 9034245 58.44 µM 0.807118885229247 0.178445978171146 no 630 0.209798996336157 1055 6462273 SGTC_2269 7935389 174.42 µM 0.801582634563503 0.17987145715059 no 631 0.2113972130279 986 97605 SGTC_231 b-estradiol 524 µM 0.800412331687834 0.18017370108367 no 632 0.211735969278757 990 450 A steroid. SGTC_3273 9137859 49.47 µM 0.798578011890778 0.180648075869668 no 633 0.212267570785038 1100 2377234 SGTC_2292 7671323 168.05 µM 0.79726789778909 0.180987364423353 no 634 0.212647730106861 1020 937504 SGTC_2440 5628896 157.78 µM 0.796090800714381 0.181292545031293 no 635 0.212989630358687 1028 5522048 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.795061656574288 0.181559630427062 no 636 0.213288818762088 1042 641818 YHR062C RPP1 SGTC_1036 k216-0215 33.5 µM 0.794773934869913 0.181634344523673 no 637 0.213372507801936 1018 622330 SGTC_2118 5526350 200 µM 0.794414741480383 0.181727645018745 no 638 0.213477012530169 1044 743594 SGTC_2199 6590217 200 µM 0.79429338255867 0.181759174778308 no 639 0.213512327774753 995 703109 SGTC_1387 3342-1166 1.8 µM 0.792645274663067 0.182187701642202 no 640 0.213992261401202 988 3418228 SGTC_1567 st069303 68.4 µM 0.790660627499653 0.182704569871894 no 641 0.214571028780485 1059 5581319 SGTC_2697 mebhydrolin 72.4 µM 0.790385733991195 0.182776233416303 no 642 0.214651265543107 1058 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2928 9011484 9.79 µM 0.787515592922126 0.183525514446616 no 643 0.215490052058686 1010 2994751 SGTC_2800 7887935 81.82 µM 0.786998369830393 0.183660744372319 no 644 0.215641410223212 1018 2961002 SGTC_541 4513-1321 94 µM 0.786155935644895 0.183881134840098 no 645 0.215888068821657 985 747515 SGTC_1682 st012968 530 nM 0.785531020298797 0.184044726238912 no 646 0.216071145059982 979 24207270 SGTC_2419 paclitaxel 166.5 µM 0.784303080568468 0.18436644223613 no 647 0.216431146158402 1059 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_88 0180-0332 8.668 µM 0.783773592531218 0.184505274181442 no 648 0.216586485803444 1121 3101745 SGTC_2995 9067767 71.4286 µM 0.780596802062998 0.185339594462265 no 649 0.217519836622018 1018 11673567 SGTC_3112 9123419 49.47 µM 0.780136855419573 0.185460584045116 no 650 0.21765516249719 1125 17015854 SGTC_1257 0669-0121 16 µM 0.779525208997627 0.185621554383954 no 651 0.217835196837992 1146 4307855 SGTC_2120 5538279 151.968 µM 0.778337101938672 0.18593448268414 no 652 0.21818515415093 1062 2058197 SGTC_3150 9097574 49.47 µM 0.777063419216846 0.186270313314228 no 653 0.218560677389614 1051 17217476 SGTC_1078 idebenone 36.1 µM 0.775417351819814 0.186704886579343 no 654 0.219046542570687 1084 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1421 4029-0249 71.4 µM 0.774362362530036 0.186983740867838 no 655 0.21935826719911 1158 2894095 SGTC_78 0336-0123 156.75 µM 0.774121556564709 0.187047426692472 no 656 0.219429455439801 968 6765896 SGTC_1693 xanthone 101.9 µM 0.773798899615181 0.187132780634753 no 657 0.219524861674617 1092 7020 An insecticide. SGTC_2641 levomentholum 100 µM 0.772960415203813 0.187354701428839 no 658 0.219772903999827 1051 16666 SGTC_1148 3909-7663 27.7 µM 0.770552906558451 0.187992797909626 no 659 0.220485992069029 1113 4084526 SGTC_664 1222-0054 14.9 µM 0.769174314167775 0.188358789334311 no 660 0.220894918267569 1104 6813991 SGTC_1280 0880-0253 10.1 µM 0.768689733649817 0.188487541055427 no 661 0.221038760463826 1061 6836607 SGTC_2652 actinonin 100 µM 0.767728621226651 0.188743066527859 no 662 0.221324214256395 1077 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_461 N-acetylfarnesylcysteine 136 µM 0.765984672190663 0.189207265165628 no 663 0.221842711254383 1130 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_286 k060-0067 22.9 µM 0.764706666770209 0.189547886377145 no 664 0.222223117716415 1060 5985051 SGTC_2953 9074162 66.49 µM 0.763255607041435 0.189935088056015 no 665 0.222655485794209 1036 16451992 SGTC_2777 climbazole 1.536 µM 0.762950922867613 0.190016451896481 no 666 0.222746332534415 1090 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3347 9188721 44.724 µM 0.762898807802877 0.190030371016029 no 667 0.222761873637857 1045 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1272 0839-0021 27 µM 0.762292821019525 0.190192266623801 no 668 0.222942628805114 1093 5027250 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.761177799254353 0.190490377505858 no 669 0.223275438322926 1080 61125 An anti-inflammatory. SGTC_1019 4262-0212 3.4 µM 0.759359456146705 0.190977142572219 no 670 0.223818779912492 1190 4677213 SGTC_1740 st038286 13.222 µM 0.758178326117861 0.191293735943619 no 671 0.224172117252431 1085 716786 SGTC_1001 4048-4355 44.4 µM 0.757703894378007 0.191420994451765 no 672 0.224314133553917 1081 21824233 SGTC_167 3672-0051 66.205 µM 0.754993947697787 0.192148887049968 no 673 0.225126306844269 1080 3237971 SGTC_3309 9129340 25.759 µM 0.753284745085225 0.192608849083699 no 674 0.225639411878709 1124 17158987 SGTC_59 0330-0160 1.33 µM 0.753147233132848 0.192645884031507 no 675 0.225680721901083 1140 4293482 SGTC_1439 4092-1168 46 µM 0.747909308779133 0.194059808752757 no 676 0.22725743116219 1103 2886240 SGTC_692 k241-0027 77.8 µM 0.747254756486237 0.194236941855698 no 677 0.227454898558906 1124 3600480 SGTC_2361 9034121 116 µM 0.745900888054393 0.194603634256387 no 678 0.227863644376268 1104 6496917 SGTC_1193 1488-0126 41.5 µM 0.745546115960069 0.194699793138983 no 679 0.227970821763805 1170 1384710 SGTC_813 k007-0158 173 µM 0.743327827530073 0.195301702335851 no 680 0.228641613944349 1151 6523916 SGTC_2771 fluoxetine 41.05 µM 0.742358260963119 0.195565138687814 no 681 0.228935150648591 1098 3386 A selective serotonin reuptake inhibitor. SGTC_22 0964-0034 14.468 µM 0.741591554560852 0.195773609560336 no 682 0.229167421003215 1140 138402 SGTC_2774 tamoxifen 10.92 µM 0.740666542723131 0.196025303833059 no 683 0.22944782512433 1174 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_253 dyclonine 31.25 µM 0.738524470478506 0.196608911444909 no 684 0.230097901333948 1183 3180 An oral anasthetic. SGTC_944 3370-0224 231 µM 0.73848529167572 0.19661959550324 no 685 0.230109800907844 1153 4580514 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.738266174646176 0.196679355194561 no 686 0.230176358530115 1074 15053 SGTC_2843 9000894 45.46 µM 0.738180351647903 0.196702764661367 no 687 0.230202430523538 1020 2242070 SGTC_1615 st002656 86.5 µM 0.737555389286112 0.196873283088942 no 688 0.230392336367082 1142 1584458 SGTC_2135 5326629 150.42 µM 0.736231180128028 0.197234883749889 no 689 0.23079500995382 1109 5020077 SGTC_2178 5812956 200 µM 0.734891397828513 0.197601145571827 no 690 0.231202818838291 1139 5403383 SGTC_750 4073-0104 132 µM 0.734397878846733 0.197736164442447 no 691 0.231353139598373 977 22330957 SGTC_2710 st078562 53.7235 µM 0.73399337481937 0.197846871813817 no 692 0.231476387963393 1133 17250908 SGTC_386 1509-0011 3.07 µM 0.733885712333426 0.197876343912566 no 693 0.23150919782219 1188 3107280 SGTC_2878 9043973 25.97 µM 0.732448182426905 0.198270115032051 no 694 0.231947529604553 1123 6465167 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.732273457211393 0.198318008334754 no 695 0.232000838319422 1146 5357218 A potent inhibitor of glutathione S-transferases. SGTC_122 0236-0016 402.397 µM 0.731081040788448 0.198645043703092 no 696 0.232364827002112 1217 6808838 SGTC_1198 1612-1005 86.7 µM 0.730943838163582 0.198682694120681 no 697 0.232406728883169 1178 6998509 SGTC_1985 st071382 65.5 µM 0.729056923498993 0.199200927674194 no 698 0.232983421524768 1197 6123237 SGTC_969 1313-0238 134 µM 0.728395040143402 0.199382903998836 no 699 0.233185899278084 1167 5212874 SGTC_15 0266-0086 27.098 µM 0.727751064658438 0.199560052813932 no 700 0.233382992521268 1245 1712902 YIL048W NEO1 SGTC_302 1094-0063 18.9 µM 0.726265019988867 0.19996920464299 no 701 0.233838159510862 1099 5440289 SGTC_2906 7926292 26.41 µM 0.724714767490739 0.200396571892907 no 702 0.234313516807666 1145 2966319 SGTC_200 k038-0079 37.545 µM 0.724483289482396 0.200460431845566 no 703 0.234384541277438 1113 3436683 SGTC_873 0591-4978 488 µM 0.723871210563352 0.200629350527415 no 704 0.234572403031489 1199 3305145 SGTC_1964 st076914 61 µM 0.723237522122115 0.200804322911901 no 705 0.234766984982123 1177 24208661 SGTC_440 fluspirilene 35.1 µM 0.722314838410363 0.201059255600443 no 706 0.235050466023673 1171 3396 An atypical antipsychotic. SGTC_1331 1472-0049 76.2 µM 0.721784086451297 0.2012059875038 no 707 0.235213617413186 1140 24051409 SGTC_558 k064-0027 21.3 µM 0.718949878821642 0.20199061999114 no 708 0.236085901093381 1156 5088526 SGTC_1291 0993-0025 5.79 µM 0.717097099944902 0.202504538638242 no 709 0.236657092529682 1174 4353356 SGTC_905 2-aminofluorene 215 µM 0.715985805451805 0.202813161109573 no 710 0.237000056857027 1219 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2890 9046729 58.44 µM 0.714883583956492 0.20311954127569 no 711 0.237340490765157 1104 903329 SGTC_529 4076-0302 30.3 µM 0.714760228105466 0.203153847199654 no 712 0.237378607353006 1110 5816522 SGTC_2999 9069765 71.4286 µM 0.714022683265177 0.203359034531075 no 713 0.237606576606434 1170 2097066 SGTC_3336 9143619 71.43 µM 0.711368582561219 0.20409843632329 no 714 0.238427931222588 1198 45595730 SGTC_65 0798-0905 34.986 µM 0.710242622419147 0.204412598992731 no 715 0.238776846993388 1243 3602145 SGTC_1232 0279-0259 161 µM 0.708603717822095 0.204870396249648 no 716 0.239285214265564 1198 1560000 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.707603454920829 0.205150100270334 no 717 0.239595773373565 1162 2333 A French combination drug. SGTC_2992 9074591 71.4286 µM 0.707485511855998 0.205183095698711 no 718 0.239632406534809 1169 17741321 SGTC_1385 3091-4834 14.1 µM 0.706590097467914 0.205433697199631 no 719 0.239910622269287 1126 4072814 SGTC_308 4092-1169 104 µM 0.705741451961158 0.205671377084864 no 720 0.240174468891561 1164 2268590 YDL196W YDL196W SGTC_1470 k295-0292 231 µM 0.705612181450391 0.205707596155939 no 721 0.240214673385266 1199 5045612 SGTC_2605 digitonin 300 nM 0.705170773931456 0.205831298444757 no 722 0.240351983423568 1235 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2084 5306078 60.6385 µM 0.700559048658064 0.207126349108992 no 723 0.241789121241927 1137 679340 SGTC_3221 9128209 49.47 µM 0.69978608587924 0.207343880841289 no 724 0.2420304527494 1195 16460723 SGTC_2964 9083345 53.42 µM 0.693711867343641 0.209058019231411 no 725 0.243931461092713 1175 17741579 SGTC_2065 5221596 34.26 µM 0.69185116680509 0.209584772131955 no 726 0.244515400139827 1181 788581 SGTC_3116 9124943 49.47 µM 0.691755509667359 0.209611873161606 no 727 0.244545440320874 1125 41905195 YPL160W CDC60 SGTC_1177 0983-0204 23.6 µM 0.691220296986801 0.209763544560189 no 728 0.24471355525917 1233 766818 SGTC_3119 9125183 49.47 µM 0.68806184393507 0.210659916711914 no 729 0.245706918592702 1071 22695334 SGTC_1025 k007-0731 70 µM 0.687413257378373 0.210844263962514 no 730 0.24591117282512 1193 6256118 SGTC_1666 st014829 29 µM 0.685749066151894 0.211317708316892 no 731 0.246435679993327 1234 3858230 SGTC_2005 4024620 188 µM 0.685696939019371 0.211332547972519 no 732 0.246452118705303 1220 236743 SGTC_3120 9124077 49.47 µM 0.683483716690303 0.211963175480466 no 733 0.247150618021593 1267 18774327 YGL155W CDC43 SGTC_3078 9116413 49.47 µM 0.682202384702529 0.21232877607553 no 734 0.247555493494546 1169 17177322 SGTC_1834 st055981 52.8 µM 0.681024325887601 0.212665234822988 no 735 0.247928049115074 1247 471719 YDL150W RPC53 SGTC_2864 9034755 47.6 µM 0.680076479557292 0.212936169751868 no 736 0.248228018197769 1221 4930451 SGTC_2278 7948257 134.34 µM 0.679856869798878 0.212998972321415 no 737 0.248297546665215 1194 1247028 SGTC_2232 chlorophetanol 41.5365 µM 0.679416493788584 0.213124940746901 no 738 0.248437001025826 1281 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_21 0849-0113 22.993 µM 0.67802361291874 0.213523656713016 no 739 0.248878360826495 1198 1560156 SGTC_1337 1486-1011 40.3 µM 0.677255573981734 0.213743695761199 no 740 0.249121906421942 1237 X1337 SGTC_3200 9114385 49.47 µM 0.676207000935341 0.214044319472211 no 741 0.249454614126251 1215 17018030 YLR208W SEC13 SGTC_2420 aureobasidin a 50 nM 0.676037746977333 0.214092867286593 no 742 0.249508339802569 1279 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_556 4058-0063 51.5 µM 0.675227519278464 0.214325357000489 no 743 0.249765612613325 1285 6615692 SGTC_1002 4049-0206 172 µM 0.675059729665215 0.214373521516126 no 744 0.249818908699686 1260 4662749 SGTC_1032 k061-1018 98.7 µM 0.673758508470889 0.214747254633338 no 745 0.250232428782499 1312 4005393 SGTC_454 lyso-paf C-16 6.67 µM 0.671908480095547 0.215279265860313 no 746 0.250820980727278 1169 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3335 9143315 29.6265 µM 0.669039169364809 0.216105902554317 no 747 0.251735246052535 1227 4899691 SGTC_2071 5230951 39.92 µM 0.667023447933972 0.216687721413734 no 748 0.252378578038502 1276 1799272 SGTC_1969 st069479 40.1 µM 0.666897274644236 0.216724170240247 no 749 0.252418875951546 1216 3895485 SGTC_906 1165-0455 526 µM 0.665830374377682 0.217032517147805 no 750 0.252759763905721 1231 3252859 SGTC_1037 k284-1091 78.7 µM 0.665624959754799 0.217091913515992 no 751 0.252825424258813 1221 3334711 SGTC_89 0302-0250 142.109 µM 0.66457479182074 0.217395720020979 no 752 0.253161248484871 1299 4203518 YLR208W SEC13 SGTC_2200 6600604 21.907 µM 0.664426138060803 0.217438744376217 no 753 0.253208804147764 1212 2904777 SGTC_2706 st078239 82.5 µM 0.663711225688841 0.217645727704067 no 754 0.253437576594295 1255 15434492 SGTC_754 3474-0146 171 µM 0.662807370982493 0.217907576782061 no 755 0.253726966120962 1195 24762078 SGTC_380 3970-0968 6 µM 0.662087613516258 0.218116222277054 no 756 0.253957536792736 1213 2891601 SGTC_2466 5983409 37.09 µM 0.661931245679388 0.218161565884117 no 757 0.254007642974257 1244 2879657 SGTC_1402 3909-7673 35.9 µM 0.661496536351905 0.218287651606996 no 758 0.25414696756843 1238 5328014 SGTC_438 sphingosine 6.67 µM 0.661379771275864 0.218321526007595 no 759 0.25418439767129 1132 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3008 9078912 71.4286 µM 0.661337923859822 0.218333666985458 no 760 0.254197812943242 1233 16648731 SGTC_1252 0493-0875 34.8 µM 0.660744600507535 0.218505846716141 no 761 0.254388058038494 1251 3960963 SGTC_1519 esterone 74 µM 0.660195770468333 0.21866518428022 no 762 0.254564103072586 1219 698 A steroid. SGTC_1769 st044406 64.4 µM 0.658849532075343 0.219056310326992 no 763 0.254996198286724 1257 670903 SGTC_2056 5235370 200 µM 0.658492266163668 0.219160175207145 no 764 0.25511093248597 1243 5511916 SGTC_1684 st024538 14.6195 µM 0.656797849134121 0.219653164067293 no 765 0.255655453706035 1241 6732859 SGTC_1624 st003710 6.25 µM 0.656730617299971 0.219672738224876 no 766 0.255677071973981 1269 24207033 SGTC_124 0136-0217 7.121 µM 0.656404463642715 0.219767710179816 no 767 0.255781959606252 1372 3976905 SGTC_428 3448-4153 16.5 µM 0.655817429486367 0.219938706723113 no 768 0.25597080028267 1208 3834874 SGTC_171 k064-0041 9.68 µM 0.655496472248223 0.220032230282519 no 769 0.256074078485506 1218 53325 SGTC_265 mycophenolic acid 32.932 µM 0.651964454690057 0.221062928924495 no 770 0.257212051546974 1348 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1120 ficusin 1.78878 µM 0.650688851433708 0.2214358481696 no 771 0.257623680651101 1342 6199 A DNA cross-linker. SGTC_2868 9035608 32.47 µM 0.650659770482251 0.221444354100255 no 772 0.257633068876698 1254 6462614 SGTC_264 promethazine 12.5 mM 0.649387771709932 0.221816585645008 no 773 0.258043882957954 1296 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_987 1497-1013 404 µM 0.648966596541329 0.221939915017872 no 774 0.258179983620662 1257 1676435 SGTC_1172 0370-0043 85 µM 0.648841467985315 0.221976562960283 no 775 0.258220425461033 1304 376585 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.647877802463675 0.222258919307819 no 776 0.258531994392081 1246 2724278 An inhibitor of dopamine biosynthesis. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.646144540686071 0.22276728465371 no 777 0.259092876085913 1337 688801 SGTC_755 1995-0008 37.3 µM 0.645576800466028 0.222933946710373 no 778 0.259276732925875 1264 689533 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.64542943760811 0.222977217181896 no 779 0.259324465893024 1249 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1523 st012844 44.7 µM 0.644553364317715 0.223234559190303 no 780 0.25960833244682 1298 4274103 SGTC_1819 st053448 58.6 µM 0.642406125856776 0.223866013857241 no 781 0.260304761636287 1247 2857616 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.639623748311548 0.22468575659782 no 782 0.261208619642486 1250 140250 A respiratory chain inhibitor. SGTC_1947 st076332 61.6 µM 0.639434511032925 0.224741571358692 no 783 0.261270152074287 1270 24208416 SGTC_2284 7945075 39.21 µM 0.639223424045557 0.224803839877652 no 784 0.261338797947176 1338 1245402 SGTC_1267 0828-0272 9.49 µM 0.63902584418854 0.224862132792559 no 785 0.261403059669696 1335 745334 SGTC_1984 st072354 53.1 µM 0.638187597039825 0.225109540071363 no 786 0.261675784996976 1227 5762938 SGTC_861 0443-0273 110 µM 0.637021938105069 0.225453838619994 no 787 0.26205527692581 1295 6149169 SGTC_1630 st005209 31.3 µM 0.636117358548212 0.225721227928905 no 788 0.262349966126986 1292 3367314 SGTC_2217 6934799 96.0675 µM 0.636103881864372 0.225725212926793 no 789 0.262354357773318 1226 675606 SGTC_2267 7931562 200 µM 0.634449366802184 0.226214748244188 no 790 0.262893800400786 1219 934880 SGTC_2034 5197015 53.07 µM 0.631034639643022 0.227226986516359 no 791 0.264008937715059 1345 780676 SGTC_2885 9057732 51.95 µM 0.630910321673304 0.227263886577489 no 792 0.264049581294904 1291 6471414 SGTC_353 1988-1175 58.3 µM 0.629371354735276 0.227720962309803 no 793 0.264552983428043 1229 2788357 SGTC_347 4534-1311 26.2 µM 0.627880543084732 0.228164228822082 no 794 0.265041098949189 1298 2862016 SGTC_2886 9058944 51.95 µM 0.625599611187708 0.228843361626316 no 795 0.265788796938048 1194 4949929 SGTC_1024 4507-0395 26 µM 0.625556737821019 0.228856137749951 no 796 0.26580286121806 1331 4201836 SGTC_3320 9137005 35.139 µM 0.624397512465031 0.229201734845119 no 797 0.266183279159284 1295 4908713 SGTC_1508 1080-0625 72.9 µM 0.623470643808695 0.22947827041108 no 798 0.266487643796373 1251 767111 SGTC_499 genistein 192 µM 0.621487455362868 0.230070591439251 no 799 0.267139472913651 1322 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2511 berberine 10.47 µM 0.619633493803346 0.230625088950061 no 800 0.267749555136431 1306 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2861 9024595 19.48 µM 0.614985443742676 0.23201854203481 no 801 0.269282166738002 1272 16482810 SGTC_1128 3448-9350 235 µM 0.614444871557726 0.232180905551747 no 802 0.269460695956526 1311 619386 SGTC_121 0557-0495 61.343 µM 0.614386500057564 0.232198441501028 no 803 0.269479977260281 1412 3104427 SGTC_3171 9103192 49.47 µM 0.613645876513933 0.232421003406662 no 804 0.269724680441471 1360 13018434 SGTC_2131 toluylene red 5.2905 µM 0.613483721421845 0.232469747831634 no 805 0.269778271584942 1295 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_913 3487-1245 167 µM 0.61253854724911 0.23275398382777 no 806 0.270090751232248 1273 4016153 SGTC_1837 st055472 66.5 µM 0.612305591667078 0.232824068677904 no 807 0.270167795400429 1365 676091 SGTC_2381 9035592 200 µM 0.612250606869103 0.232840612603133 no 808 0.270185981835271 1257 4749657 SGTC_547 1120-0019 610 nM 0.609910227085678 0.233545395530356 no 809 0.27096063870423 1332 3676939 SGTC_2532 xanthone 78.9 µM 0.609616417731328 0.233633956908432 no 810 0.271057966723178 1306 7020 An insecticide. SGTC_3092 9117248 49.47 µM 0.608640266296607 0.233928326658189 no 811 0.271381454233816 1370 17141857 SGTC_3233 9132340 49.47 µM 0.608258243627075 0.234043585931837 no 812 0.271508105347044 1281 17682950 SGTC_2552 juarezic acid 87.02 µM 0.608230497336235 0.234051958433195 no 813 0.271517305158846 1359 1549512 SGTC_1205 4161-2785 76 µM 0.607564262260017 0.23425304606824 no 814 0.271738254714059 1292 3498106 SGTC_3044 9093193 49.47 µM 0.606309811640773 0.234631932385701 no 815 0.272154522239721 1294 25236277 SGTC_2904 7225135 42.03 µM 0.605912167107259 0.234752105124031 no 816 0.272286539763707 1400 4446116 SGTC_1812 st052057 4.327 µM 0.605853526729569 0.234769829797255 no 817 0.272306010992957 1301 3645418 SGTC_3037 9091026 49.47 µM 0.605764544285913 0.234796727093272 no 818 0.272335558467041 1345 25236398 YIL048W NEO1 SGTC_2085 5307070 144.047 µM 0.604719423127241 0.235112770061378 no 819 0.272682720146866 1286 2840351 SGTC_696 1560-0013 611 µM 0.603768866288048 0.235400420847766 no 820 0.272998660648244 1374 1650269 SGTC_530 4358-1714 28 µM 0.60307063419096 0.235611838584592 no 821 0.273230850490165 1375 1564641 SGTC_144 4161-2749 112.381 µM 0.601520533387878 0.236081567847397 no 822 0.273746669867314 1260 797501 YMR168C CEP3 SGTC_2731 amoxapine 43.43 µM 0.59917470787103 0.23679340686199 no 823 0.274528193460522 1384 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2461 5755302 26.15 µM 0.597037713394522 0.237442902286226 no 824 0.275241100830152 1414 2788904 SGTC_3253 9135987 49.47 µM 0.597005917187549 0.237452573466369 no 825 0.275251715011265 1347 4182430 SGTC_1064 honokiol 6.76 µM 0.596388014150947 0.237640558671642 no 826 0.275458022840189 1324 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_963 1269-2853 151 µM 0.596222060501978 0.237691060809132 no 827 0.275513445035094 1320 3668223 SGTC_1463 k081-0032 34.1 µM 0.595492822264212 0.237913048503981 no 828 0.275757047800175 1235 977755 SGTC_2136 5328288 199.296 µM 0.595371397569544 0.237950022478981 no 829 0.275797620119387 1316 262395 SGTC_2748 diazoxide 86.69 µM 0.595175652620251 0.238009633698758 no 830 0.275863031660574 1344 3019 A potassium channel activatior. SGTC_2834 9001755 58.44 µM 0.594611782876512 0.238181397608332 no 831 0.276051501023831 1364 2989575 SGTC_1459 k035-0031 35.7 µM 0.592024580005138 0.238970371790158 no 832 0.276917064448181 1247 3877128 YMR208W ERG12 SGTC_1026 k007-1105 30.6 µM 0.591669812251538 0.239078670428295 no 833 0.277035857541926 1347 7066794 SGTC_2432 5630864 12.22 µM 0.588456061555821 0.240060941406144 no 834 0.278113108888597 1333 5714970 SGTC_2474 5321570 43.32 µM 0.587827898106043 0.240253193970555 no 835 0.278323908160938 1419 2841384 SGTC_2738 aclarubicin 5.55 µM 0.586608633274925 0.240626595411153 no 836 0.278733291566595 1331 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1167 k781-0610 148 µM 0.586270621752594 0.24073016778195 no 837 0.278846835033275 1392 4525169 SGTC_2218 6965428 192.983 µM 0.584541024078448 0.241260524870357 no 838 0.279428186494295 1364 675684 SGTC_301 4119-0100 24.5 µM 0.584186536062235 0.241369302048746 no 839 0.279547409470596 1363 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1893 st059353 36.1 µM 0.579950528738855 0.242671210408231 no 840 0.280973989854926 1329 3112488 SGTC_1609 st001574 46.4 µM 0.57859113522818 0.243089815229362 no 841 0.28143254382666 1335 3960012 SGTC_830 4076-0286 57.8 µM 0.578336784806799 0.243168181967171 no 842 0.281518382025595 1414 6866659 SGTC_732 3970-1727 52.7 µM 0.575183827584065 0.244140758270743 no 843 0.282583489573783 1447 1275699 SGTC_62 0180-0423 3.232 µM 0.573914478431752 0.244532899217134 no 844 0.28301283750848 1335 30102 YGL099W LSG1 SGTC_63 0099-0242 26.702 µM 0.571549475020535 0.245264425484526 no 845 0.283813616581373 1374 3898502 YLR359W ADE13 SGTC_127 0180-0333 59.125 µM 0.570200746805491 0.245682130819585 no 846 0.284270774819036 1355 771601 SGTC_2601 securinine 100 µM 0.569007873994063 0.246051885355296 no 847 0.284675398193788 1345 442872 A GABA receptor antagonist. SGTC_361 000s-0510 1.45 µM 0.5656359595554 0.247098689540236 no 848 0.285820638778582 1384 660 SGTC_175 3793-3120 23.7 µM 0.565121589386425 0.247258583901553 no 849 0.28599553242586 1383 5322297 SGTC_1376 2910-0861 41.3 µM 0.564049550807854 0.247592009804583 no 850 0.286360205158929 1437 1112859 SGTC_2396 5342950 42.78 µM 0.563969081320857 0.247617047146568 no 851 0.286387587170379 1409 1886677 SGTC_1733 st037357 54.9 µM 0.563723009107418 0.247693618646468 no 852 0.286471327887745 1327 1272339 YGL099W LSG1 SGTC_294 k038-0071 157 µM 0.563495233693545 0.247764507909529 no 853 0.286548852383531 1381 24152826 SGTC_2148 5546263 113.568 µM 0.562094737367037 0.248200614479265 no 854 0.287025736865216 1400 792097 SGTC_1334 1486-0610 236 µM 0.560526043223856 0.248689582531589 no 855 0.287560340453485 1415 3742339 SGTC_2239 6685329 187.64 µM 0.559593021337848 0.248980652199047 no 856 0.287878533021817 1399 805680 SGTC_2955 9076254 12.21 µM 0.557942578034785 0.249495975490944 no 857 0.288441797825219 1367 16459619 SGTC_540 1187-0821 17.3 µM 0.5574071370922 0.249663279639392 no 858 0.288624645135474 1381 847520 SGTC_1310 1188-0297 994 nM 0.5560381090347 0.250091317642356 no 859 0.289092401556885 1369 1588352 SGTC_620 0109-0052 432 µM 0.555159416029467 0.250366253301404 no 860 0.289392812706232 1420 493037 SGTC_2496 diffractaic acid 79.83 µM 0.553367175319011 0.250927526655324 no 861 0.290006005492684 1516 94870 An apoptosis inducer which activates caspases. SGTC_672 1441-0018 53.7 µM 0.552648445043384 0.251152797281289 no 862 0.29025208108681 1362 251141 SGTC_2812 7970281 58.44 µM 0.552115094819766 0.251320033612096 no 863 0.290434750299638 1509 2233435 SGTC_2623 humulene 100 µM 0.550808288747597 0.2517300420712 no 864 0.290882550765651 1350 6187145 An anti-inflammatory. SGTC_727 3032-0951 202 µM 0.549889727992125 0.252018450400276 no 865 0.291197505042571 1416 3652836 SGTC_880 0833-0487 87.2 µM 0.547163562433964 0.25287543328734 no 866 0.292133183466681 1375 76075 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.546690451805492 0.253024313869882 no 867 0.292295707539736 1448 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_753 1322-0200 289 µM 0.545823411988738 0.25329727752122 no 868 0.292593664196096 1413 5403907 SGTC_3352 9151559 45.5865 µM 0.544320949029649 0.253770653009679 no 869 0.293110316733004 1366 17159339 SGTC_1145 3546-0597 10.2 µM 0.543939124510357 0.253891027035035 no 870 0.293241682276229 1414 875334 SGTC_610 4215-0184 155 µM 0.543609928004261 0.253994833601105 no 871 0.293354963218881 1452 5605015 SGTC_2773 thioridazine 9.09 µM 0.54319231063055 0.254126554234606 no 872 0.293498700142995 1422 5452 An antipsychotic. SGTC_100 0086-0128 49.5915 µM 0.542756191646929 0.254264148693164 no 873 0.293648839820899 1335 93297 SGTC_2375 9072683 200 µM 0.542686206266026 0.254286232543775 no 874 0.293672936515865 1529 16798029 SGTC_305 1682-2595 20.8 µM 0.541242843363794 0.254741909087508 no 875 0.294170105338139 1440 226033 SGTC_375 3970-0961 9.27 µM 0.538507318495047 0.255606698886842 no 876 0.295113426971365 1446 2898222 SGTC_2658 polymyxin b sulfate 77.05 µM 0.537976758255959 0.255774603867519 no 877 0.295296547161814 1401 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1520 flindersine 88 µM 0.537761496551147 0.25584274357965 no 878 0.295370858562848 1571 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1956 st077085 54 µM 0.536577298675409 0.256217763180865 no 879 0.295779814276507 1400 24208685 SGTC_2735 sertaconazole 140 nM 0.536104356208727 0.256367617772755 no 880 0.295943214812838 1488 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1697 st025554 27.742 µM 0.535898855092546 0.256432746238265 no 881 0.296014227891769 1409 1269519 SGTC_2069 5228469 200 µM 0.533950491164499 0.257050659780904 no 882 0.296687893891721 1380 2835210 SGTC_1961 st076550 68.7 µM 0.533374853600742 0.257233368347962 no 883 0.296887060512758 1427 1579337 SGTC_1366 1683-0113 21.9 µM 0.533311770391249 0.257253395194474 no 884 0.296908890586814 1424 708623 SGTC_1771 st048882 4.1505 µM 0.53185805608857 0.257715126170601 no 885 0.29741215474972 1373 4580403 SGTC_1912 st060209 90.8 µM 0.53142521477791 0.257852688966491 no 886 0.297562076159153 1389 688787 SGTC_3332 9141069 11.198 µM 0.529826588242823 0.258361084046362 no 887 0.298116084415963 1391 17332883 SGTC_199 4063-0024 41.6 µM 0.528595559113673 0.258752929503265 no 888 0.298543020804857 1486 306215 SGTC_2255 7941087 197.44 µM 0.527558530385732 0.259083261767632 no 889 0.298902891095467 1533 935561 SGTC_109 0132-0036 33.701 µM 0.527024018427073 0.259253608849472 no 890 0.299088454665312 1368 67274 A color developer. SGTC_611 3453-1652 23.7 µM 0.52683949773539 0.259312428382578 no 891 0.299152525837709 1495 1560575 SGTC_142 0335-0849 62.6745 µM 0.522957665163359 0.26055143397212 no 892 0.30050185709673 1489 3889043 YPR107C YTH1 SGTC_567 1080-0542 68.4 µM 0.522090961023218 0.260828484748698 no 893 0.300803499822015 1449 5950415 SGTC_1105 epirubicin 18.1 µM 0.521872634193857 0.260898299024605 no 894 0.30087950656989 1396 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1445 4239-0156 97.7 µM 0.521192369193621 0.261115888679776 no 895 0.301116384703825 1591 4008346 SGTC_2922 7999257 32.47 µM 0.520715861032702 0.261268360177308 no 896 0.301282361785167 1417 2988377 SGTC_907 3448-6986 75.5 µM 0.519265608966328 0.26173268830519 no 897 0.301787766174506 1549 590582 SGTC_1671 st016596 74.5 µM 0.517218932936277 0.262388693482431 no 898 0.302501668476361 1444 2829167 SGTC_2197 6588183 93.1375 µM 0.51717783602322 0.262401874574437 no 899 0.302516011266589 1431 884136 SGTC_2089 5281248 129.67 µM 0.511709987889628 0.264158606346779 no 900 0.304426997432974 1452 2737878 SGTC_14 0354-0009 295 µM 0.511650478819608 0.264177758557675 no 901 0.30444782509221 1499 1713507 SGTC_2775 cyproheptadine 69.59 µM 0.511081668442962 0.264360858372605 no 902 0.304646935791437 1473 2913 A selective serotonin reuptake inhibitor. SGTC_1228 0124-0032 52.5 µM 0.510907366606979 0.264416978987004 no 903 0.304707961318515 1558 X1228 SGTC_3305 9127027 53.8275 µM 0.509027882386433 0.26502250852735 no 904 0.3053663401756 1462 41905295 SGTC_2372 9071633 200 µM 0.508929530873078 0.265054214664454 no 905 0.305400809843181 1502 21321366 SGTC_195 4234-0266 16.654 µM 0.508122098326539 0.265314584116299 no 906 0.305683859320112 1451 2303354 SGTC_2471 5466956 24.79 µM 0.507651629006615 0.26546635426345 no 907 0.305848838234859 1494 724419 SGTC_2744 captopril 92.04 µM 0.500691114478833 0.267716902775246 no 908 0.30829426333574 1571 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2011 4012611 177 µM 0.500005389630269 0.267939137862915 no 909 0.308535641226602 1446 2049887 SGTC_831 k061-1017 217 µM 0.499608433280108 0.268067829032992 no 910 0.308675409283593 1566 1240153 SGTC_1779 st039427 55 µM 0.49833324018833 0.26848145036903 no 911 0.309124591376927 1633 1124498 SGTC_3121 9125696 49.47 µM 0.497978863657905 0.268596452805428 no 912 0.309249469935041 1533 1235365 SGTC_1851 st056236 18.9 µM 0.497727968143607 0.268677888500451 no 913 0.309337896198876 1538 5393171 SGTC_2126 5251174 33.877 µM 0.49733060735474 0.268806889288966 no 914 0.30947796565599 1646 790722 SGTC_129 0088-0017 176.636 µM 0.497004472106086 0.268912790373441 no 915 0.309592948835287 1518 182446 SGTC_1864 st057645 30.4 µM 0.49580733199001 0.269301699495238 no 916 0.31001517570129 1504 688666 SGTC_354 2783-3500 4.88 µM 0.49516354444124 0.269510960210269 no 917 0.310242340859579 1416 6740761 SGTC_682 0kpi-0099 17 µM 0.495127847574698 0.269522565726278 no 918 0.310254938880724 1471 1714895 YML126C ERG13 SGTC_1932 st074806 40.9 µM 0.494655219120694 0.269676246995111 no 919 0.310421758351635 1561 17251235 SGTC_2153 5569715 200 µM 0.494534554936347 0.269715489551477 no 920 0.310464354369282 1508 2054701 SGTC_3096 9117468 49.47 µM 0.494462958109356 0.269738775712687 no 921 0.310489630176801 1425 41316311 SGTC_473 2-arachidonoylglycerol 10 µM 0.49443985331202 0.269746290534822 no 922 0.310497787047832 1464 5282280 An endocannabinoid. SGTC_3356 9151811 4.48 µM 0.494046687918326 0.269874183424671 no 923 0.310636603646669 1461 1859254 YPR165W RHO1 SGTC_2745 rifampicin 24.3 µM 0.493478722744184 0.270058990571381 no 924 0.310837185168294 1566 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.493163110161815 0.270161713421041 no 925 0.310948670625819 1535 676296 Flavone; oxidizing agent. SGTC_1051 3253-3903 78 µM 0.491794556451157 0.270607364404065 no 926 0.311432292564279 1456 5509239 SGTC_60 0986-0278 202 µM 0.491777310201945 0.270612982753432 no 927 0.311438389153359 1316 3110598 SGTC_609 0986-0026 86.3 µM 0.491644204450769 0.270656346873116 no 928 0.311485444084441 1538 2848610 SGTC_2717 st081029 62.2815 µM 0.491242503254782 0.270787236925562 no 929 0.311627470305422 1490 5292846 SGTC_1088 bifonazole 369 nM 0.491110357273565 0.270830302190975 no 930 0.311674198211802 1460 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_271 rotenone 740 µM 0.491043320256599 0.270852150298681 no 931 0.311697904212136 1531 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_176 1486-1328 72.834 µM 0.489955687389603 0.271206744784128 no 932 0.312082627937327 1480 22310231 SGTC_2196 6573537 42.6665 µM 0.488867259443978 0.27156183002634 no 933 0.312467838197895 1580 2903087 SGTC_2054 5233173 129 µM 0.487276486817816 0.272081214704563 no 934 0.313031204147002 1532 6889 SGTC_956 1185-0240 191 µM 0.486369105554618 0.272377694258483 no 935 0.313352745429489 1501 1416193 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.485657969116498 0.2726101645046 no 936 0.313604844255905 1483 3256 An antibiotic and ribosome inhibitor. SGTC_2736 butenafine 14.65 µM 0.485398590991102 0.272694979625406 no 937 0.313696815829801 1551 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1248 0469-0687 58.6 µM 0.485292229015609 0.272729763150971 no 938 0.313734533531403 1572 4017482 SGTC_1171 0368-0077 21.4 µM 0.483900614040019 0.273185065316393 no 939 0.314228202290339 1472 3239779 SGTC_2411 st077133 39.94 µM 0.481116830154569 0.274096979591206 no 940 0.315216733561145 1648 1403142 YNL221C POP1 SGTC_3017 9080681 49.47 µM 0.479706451569342 0.274559565904718 no 941 0.315718069883615 1489 16451914 SGTC_2666 tannic acid 100 µM 0.479695143791667 0.274563276268363 no 942 0.315722090743646 1536 16134267 A thiamine antagonist. SGTC_2237 6667747 47.222 µM 0.476807304911179 0.275511657178005 no 943 0.316749671759845 1524 729940 YDL015C TSC13 SGTC_1309 pyrazolanthrone 13.4 µM 0.476561480154982 0.275592461626778 no 944 0.316837209180687 1609 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_613 3914-0030 117 µM 0.475427556270739 0.275965341731449 no 945 0.317241128597702 1456 1145395 SGTC_1398 3558-0053 112 µM 0.474506945469835 0.276268257993585 no 946 0.317569223157375 1490 4532369 SGTC_650 1328-0195 38 µM 0.47356322762649 0.276578946603784 no 947 0.317905701583035 1542 2780821 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.47253015511465 0.27691924859359 no 948 0.318274211457711 1486 5355888 SGTC_1945 st075991 56.6 µM 0.471450105581897 0.277275244247876 no 949 0.318659671012081 1469 1084980 SGTC_2891 9063876 19.48 µM 0.470705735695028 0.277520726593549 no 950 0.318925443947033 1550 6472478 SGTC_1206 3978-0017 132 µM 0.470178929696444 0.277694523697863 no 951 0.31911359325148 1598 3873677 SGTC_2261 9010538 184.68 µM 0.468143448224212 0.278366542830828 no 952 0.319841005147899 1460 6457250 SGTC_3234 9132280 49.47 µM 0.467667646203105 0.278523744235381 no 953 0.320011140703388 1525 17612295 SGTC_848 0368-0089 85.6 µM 0.466690553743768 0.278846703751154 no 954 0.320360644548548 1556 762535 SGTC_2851 9015922 71.43 µM 0.466207669854034 0.279006379185324 no 955 0.320533429938355 1594 2996893 SGTC_2150 5556613 200 µM 0.465895576724441 0.279109602815331 no 956 0.320645123720783 1562 743190 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.46497533275811 0.279414078098175 no 957 0.320974560732872 1546 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1016 4226-1401 38 µM 0.461989370421715 0.280403134067762 no 958 0.322044471570437 1512 2901613 SGTC_1665 st014639 11.4 µM 0.460962840694912 0.280743548005181 no 959 0.322412632639343 1605 981133 YIL048W NEO1 SGTC_1438 4092-1045 4 µM 0.460615170202445 0.28085888648215 no 960 0.32253736288611 1508 1351342 SGTC_697 0508-1955 564 µM 0.460595569592703 0.28086538959836 no 961 0.32254439539474 1634 6243113 SGTC_1005 4092-0690 4.4 µM 0.460044106411457 0.281048384610171 no 962 0.322742281048088 1505 1529343 SGTC_2855 9016525 58.44 µM 0.458728029873289 0.281485338044646 no 963 0.32321474143205 1495 43811474 SGTC_150 3970-0969 77.2 µM 0.45804003160263 0.281713892225852 no 964 0.323461840617302 1578 6615640 SGTC_1982 st072467 71.9 µM 0.457035036897694 0.282047913860449 no 965 0.323822931141936 1522 3163533 SGTC_2172 5754775 163.918 µM 0.455214942933529 0.282653328197223 no 966 0.324477305605378 1492 2263357 SGTC_554 4483-2211 187 µM 0.45292763544283 0.283415035326868 no 967 0.325300425246816 1562 747107 SGTC_2840 9008771 71.43 µM 0.452432342789775 0.283580104604475 no 968 0.325478775740267 1685 2992978 SGTC_2816 7982706 58.44 µM 0.451667277909327 0.283835173052257 no 969 0.3257543473643 1513 2981853 SGTC_2734 clemastine 41.6 µM 0.451336999890126 0.2839453198685 no 970 0.3258733408982 1574 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1862 st057513 3.81 µM 0.450586820094611 0.284195578745887 no 971 0.326143683765193 1534 5393163 SGTC_1954 st077032 68.9 µM 0.450517469776908 0.284218719234374 no 972 0.326168680209246 1468 698907 SGTC_2671 danthron 100 µM 0.449591308923404 0.284527842557699 no 973 0.326502577986183 1553 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1678 st019265 80.2 µM 0.447935352096738 0.28508094868224 no 974 0.327099926892812 1697 5367020 SGTC_158 k038-0087 26.446 µM 0.44683022617296 0.285450356740642 no 975 0.327498822725448 1585 X158 SGTC_1073 triclabendazole 3.09 µM 0.444908596857215 0.286093237801878 no 976 0.328192904847208 1589 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1565 sinapyl alcohol 95.1 µM 0.444127601825641 0.286354716139445 no 977 0.328475165816009 1481 5280507 A phenol propionate derived from cinnamic acid. SGTC_3330 9141424 71.43 µM 0.443227392117952 0.286656248398991 no 978 0.328800633873688 1653 27261020 SGTC_3182 9108849 49.47 µM 0.44130892553744 0.28729935561656 no 979 0.329494682671041 1558 17133045 SGTC_2969 9091408 28.7 µM 0.440373697767302 0.287613109438214 no 980 0.329833235791985 1480 4286311 SGTC_2143 5623677 140.463 µM 0.439032789787089 0.288063244791455 no 981 0.330318888703889 1575 5375313 SGTC_3009 9080819 71.4286 µM 0.438652344510449 0.28819101867813 no 982 0.330456731297744 1557 17027216 SGTC_2591 skatole 100 µM 0.438411164571506 0.288272033655078 no 983 0.330544127314302 1570 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_731 3966-0296 387 µM 0.438100246128787 0.288376490403199 no 984 0.330656808004427 1572 660956 SGTC_744 1594-0068 283 µM 0.437269396930334 0.288655711591065 no 985 0.33095799332265 1562 668392 SGTC_3216 9129716 49.47 µM 0.437172164408082 0.288688396576573 no 986 0.330993247559188 1495 8056934 SGTC_3296 9122258 64.045 µM 0.436815701836887 0.288808237376527 no 987 0.33112250535902 1576 4730474 SGTC_423 5-fluorouracil 457 µM 0.436296110717238 0.288982963052917 no 988 0.331310951665857 1480 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2629 bisabolol 100 µM 0.43563860953208 0.28920413573905 no 989 0.331549476695098 1653 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2195 6536160 144.242 µM 0.434054728531832 0.289737253989964 no 990 0.332124349617983 1504 3834386 SGTC_2640 pentamidine 10.38 µM 0.433577448754302 0.28989799188488 no 991 0.332297656882461 1689 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1039 k821-0043 94 µM 0.43302919483728 0.290082683988357 no 992 0.332496780157233 1678 15992768 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.432258456260514 0.290342418452404 no 993 0.33277678876718 1535 4174840 SGTC_1809 st050081 57.6 µM 0.431060156680241 0.290746454650679 no 994 0.333212315140904 1640 5036894 SGTC_2986 9022445 71.43 µM 0.43076411673049 0.290846312292222 no 995 0.3333199466284 1689 6459286 SGTC_502 l-744,832 89.3 µM 0.428389512920827 0.291647872606763 no 996 0.334183779263664 1679 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_634 1611-4317 11.2 µM 0.428260020491497 0.291691613067632 no 997 0.33423091129459 1637 2843522 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.427930364602335 0.291802979324821 no 998 0.334350909653441 1562 16486 A toxic proline analog. SGTC_998 3996-0085 177 µM 0.427157175809391 0.292064260119632 no 999 0.33463242525291 1723 715391 SGTC_2957 9076800 11.52 µM 0.42695820011336 0.292131516846107 no 1000 0.334704886726206 1541 16459615 SGTC_1405 3909-7894 12 µM 0.425740183532675 0.292543381471573 no 1001 0.335148588945761 1676 7104060 SGTC_2662 daunorubicin 22.37 µM 0.425323124693563 0.292684469278371 no 1002 0.335300569135147 1555 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_485 niflumic acid 177 µM 0.42378020124565 0.293206702986798 no 1003 0.335863059253668 1622 4488 A COX2 inhibitor. SGTC_2246 7293507 91.5585 µM 0.423211648722971 0.293399249977557 no 1004 0.336070424300963 1741 887656 SGTC_2481 5478948 45.16 µM 0.422301232811374 0.293707694971453 no 1005 0.336402579217159 1578 77792 SGTC_2610 ononetin 44.17 µM 0.421726033773806 0.293902647257322 no 1006 0.336612499916102 1547 259632 SGTC_2935 9038016 29.96 µM 0.4211297364753 0.294104813536726 no 1007 0.33683017425533 1613 6463195 SGTC_574 1315-0397 40 µM 0.420243488337939 0.294405402288668 no 1008 0.337153794195491 1572 6794277 SGTC_1214 0358-0031 63.7 µM 0.417886311012797 0.295205575517119 no 1009 0.338015120757178 1781 4301366 SGTC_2900 5328528 85.29 µM 0.417867025574481 0.295212126326913 no 1010 0.338022171276886 1543 795359 SGTC_336 4111-0029 111 µM 0.41767847715294 0.295276175316042 no 1011 0.338091105260113 1567 3131175 SGTC_1776 st049249 45.9 µM 0.415994452036943 0.295848513962011 no 1012 0.338707031465085 1551 1822314 SGTC_2505 galangin 7.89 µM 0.413900337345746 0.296560936986564 no 1013 0.339473548411298 1556 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1326 1431-2094 10.8 µM 0.413618338284021 0.296656933784526 no 1014 0.339576820465903 1563 616278 SGTC_250 brefeldin a 552.239 µM 0.412988562750854 0.296871370381102 no 1015 0.339807496676456 1577 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_789 1309-1135 70.6 µM 0.412476669394982 0.297045720708489 no 1016 0.339995038834977 1559 3092424 SGTC_2356 9061756 188.97 µM 0.410236064487528 0.297809418828644 no 1017 0.340816393837898 1701 20104043 SGTC_1675 st018485 24.5 µM 0.410186071428979 0.297826468902453 no 1018 0.340834728787877 1613 3323024 SGTC_184 1494-0393 24.714 µM 0.410078148528008 0.297863277398625 no 1019 0.340874310784528 1559 3090647 SGTC_812 4251-0442 148 µM 0.409620796760611 0.298019286129911 no 1020 0.341042069376082 1638 5723007 SGTC_965 1291-5240 308 µM 0.409228001671487 0.298153303442994 no 1021 0.341186173391236 1702 2834598 SGTC_2751 anetholtrithion 17.25 µM 0.409196565058522 0.298164030451871 no 1022 0.341197707485316 1713 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2575 plumbagin 510 nM 0.407535975001809 0.298730917687099 no 1023 0.341807188707477 1552 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1672 st016598 6.51 µM 0.407158432765693 0.298859870244135 no 1024 0.341945814482406 1562 4665860 YNL267W PIK1 SGTC_3348 9149464 3.537 µM 0.407004387131112 0.298912493021313 no 1025 0.342002383006312 1598 1951442 SGTC_964 1287-0107 19.4 µM 0.406080955083786 0.299228030337951 no 1026 0.342341559357015 1718 51516812 YPR165W RHO1 SGTC_1416 3966-0321 25.3 µM 0.405346544221388 0.299479086840607 no 1027 0.34261139910444 1630 582530 YLR208W SEC13 SGTC_2459 5811157 9.22 µM 0.404823867782918 0.299657820605826 no 1028 0.342803491609529 1589 2870684 YBR192W RIM2 SGTC_36 0335-0881 14.2 µM 0.404280685196567 0.299843617816832 no 1029 0.34300316354608 1636 23828853 SGTC_933 2914-0560 114 µM 0.404013245141491 0.299935115635751 no 1030 0.343101489648241 1776 463887 SGTC_1050 3232-1156 69.3 µM 0.403617952952536 0.300070377949747 no 1031 0.343246840887449 1584 700529 SGTC_714 4296-0578 26.1 µM 0.402819135753069 0.300343803896627 no 1032 0.34354064139175 1706 1589775 SGTC_579 4491-1009 110 µM 0.401093719097598 0.300934778069473 no 1033 0.34417556247811 1795 1271041 SGTC_2902 5787006 60.46 µM 0.400334870070544 0.301194858114977 no 1034 0.344454944003162 1594 591003 SGTC_1488 4013-0813 75.9 µM 0.398891485832965 0.301689827904907 no 1035 0.344986581493581 1606 2910057 SGTC_1462 k081-0014 26.5 µM 0.398043454823459 0.301980807793098 no 1036 0.345299077122641 1525 3270634 SGTC_1335 1486-0900 202 µM 0.398003745994272 0.301994435939045 no 1037 0.345313712235536 1612 X1335 SGTC_708 3448-5400 146 µM 0.397204540480987 0.302268783504902 no 1038 0.345608317107911 1619 3462195 SGTC_975 1335-0046 28.5 µM 0.396174181374025 0.302622645330522 no 1039 0.345988268326742 1544 16486740 SGTC_3251 9135047 49.47 µM 0.395709445449686 0.302782312838074 no 1040 0.346159693324317 1730 17682963 SGTC_1944 st076371 56.9 µM 0.394164141465126 0.303313497972633 no 1041 0.346729929016911 1593 24208455 SGTC_1828 st055811 49 µM 0.39285390209118 0.303764207657204 no 1042 0.347213695278243 1749 5877589 SGTC_937 3122-0005 46.7 µM 0.392181173176295 0.303995735951398 no 1043 0.347462176900874 1747 759535 SGTC_2064 5220758 200 µM 0.390963750011126 0.304414927643738 no 1044 0.347912015415712 1663 788518 SGTC_1346 1488-2224 62.4 µM 0.387851083329891 0.305487870851053 no 1045 0.349063119861106 1741 3722427 SGTC_2024 5144227 134 µM 0.384502405345417 0.306644035812435 no 1046 0.350303056730765 1714 3475211 SGTC_560 2332-1943 155 µM 0.38340061644034 0.307024861411559 no 1047 0.35071137316891 1659 21177716 SGTC_1428 4049-0204 61.7 µM 0.383224761052745 0.307085663876951 no 1048 0.350776560109614 1742 X1428 SGTC_1344 1488-0097 29.1 µM 0.382329339314589 0.307395340560995 no 1049 0.351108547546107 1678 747966 SGTC_2233 sulbentine 40.3845 µM 0.3812248364989 0.307777515987966 no 1050 0.351518210649589 1637 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_148 3253-0744 288.01 µM 0.380410315679414 0.308059486762253 no 1051 0.351820429195862 1608 6893655 SGTC_2762 leflunomide 42.06 µM 0.380269056131631 0.308108399521913 no 1052 0.35187285145482 1677 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2004 4023728 41.89 µM 0.379451232373724 0.308391647465478 no 1053 0.352176406037028 1780 360084 YDR527W RBA50 SGTC_3162 9099653 49.47 µM 0.378683765046517 0.308657558571702 no 1054 0.352461355337007 1710 25237511 SGTC_647 0140-0236 81 µM 0.377694059362566 0.309000618703874 no 1055 0.352828940715887 1704 990837 SGTC_1282 0886-0010 32.4 µM 0.376555292650114 0.309395553831544 no 1056 0.35325205868816 1787 2836211 YNL267W PIK1 SGTC_1184 1269-1718 139 µM 0.375352367376366 0.309812979005954 no 1057 0.353699212382771 1776 5403821 SGTC_3313 9133968 57.047 µM 0.37429939650285 0.310178570154114 no 1058 0.354090790511275 1676 1494643 SGTC_2385 9074692 200 µM 0.373135108985804 0.310583028920214 no 1059 0.35452394468813 1632 17046906 SGTC_468 gf-109203x 121 µM 0.372198288318307 0.310908634928586 no 1060 0.354872610210841 1757 2396 A protein kinase C inhibitor. SGTC_685 1278-0033 54.9 µM 0.371560915774658 0.311130247949698 no 1061 0.355109896778871 1747 3590572 SGTC_2025 5147754 141 µM 0.371498987806592 0.311151783818838 no 1062 0.355132954855828 1756 315777 YLR208W SEC13 SGTC_2329 6138490 200 µM 0.371163027856762 0.311268627426787 no 1063 0.355258054435806 1675 720019 SGTC_707 0865-0008 204 µM 0.370871057135218 0.311370187455083 no 1064 0.355366786656571 1731 723043 SGTC_1777 st045864 34.765 µM 0.369450636022854 0.311864475989757 no 1065 0.355895930617507 1677 4691462 SGTC_2994 9053520 71.4286 µM 0.369342129119492 0.311902248966341 no 1066 0.355936363703865 1780 4647384 SGTC_3202 9113761 49.47 µM 0.368640041819982 0.31214670450844 no 1067 0.356198022668207 1820 4798415 SGTC_797 k781-0471 270 µM 0.366909117080263 0.312749738021496 no 1068 0.356843405297429 1739 23738129 SGTC_2667 digitoxin 100 µM 0.36564307492006 0.313191129675598 no 1069 0.357315714198887 1770 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1115 galangin 695.678 nM 0.364157659946033 0.313709344652732 no 1070 0.357870140952735 1785 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3289 9119912 71.43 µM 0.362989795215722 0.31411703457127 no 1071 0.358306253712566 1698 17014829 SGTC_2177 5811945 192 µM 0.362603796342927 0.314251832847465 no 1072 0.358450436975995 1755 5343475 SGTC_2434 5670830 169.91 µM 0.362171038198431 0.314402989827775 no 1073 0.358612110360351 1686 1549830 SGTC_1529 apigenin 74 µM 0.361842826186365 0.314517650912925 no 1074 0.358734743430979 1789 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1836 st055642 81 µM 0.36165061241559 0.314584809230381 no 1075 0.358806568909209 1623 8571 SGTC_441 propafenone 146 µM 0.360919772309443 0.314840216294235 no 1076 0.359079711141009 1657 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_822 1487-0950 154 µM 0.360718192102755 0.314910678223702 no 1077 0.359155061873532 1795 1958375 SGTC_2291 7917025 104.35 µM 0.358685096780815 0.3156217186456 no 1078 0.35991533928381 1624 2964612 SGTC_941 3237-0776 460 µM 0.35865265839948 0.315633068959361 no 1079 0.359927474141546 1792 760008 SGTC_2340 7987427 183.45 µM 0.357173835751283 0.316150699207039 no 1080 0.360480835911768 1732 2239331 SGTC_1246 0422-0085 105 µM 0.356901445116565 0.31624608307647 no 1081 0.360582793886791 1818 264295 SGTC_1830 st055982 50.3 µM 0.355959069348407 0.31657617201325 no 1082 0.360935609038426 1831 455313 An antimicrobial agent. SGTC_1089 terbinafine 2.25 µM 0.354821748844874 0.316974739465299 no 1083 0.361361566969288 1772 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1981 st071826 47 µM 0.354626795284975 0.317043081167002 no 1084 0.361434599735061 1682 11838600 SGTC_791 1348-1292 225 µM 0.353899837204127 0.317297974063082 no 1085 0.361706974522901 1795 5437054 SGTC_678 1218-2179 85.9 µM 0.352052738876965 0.317946010801599 no 1086 0.362399355554182 1740 6820081 YOR116C RPO31 SGTC_2376 9072922 81.32 µM 0.350599945182313 0.318456101641172 no 1087 0.36294424883371 1724 17087968 SGTC_2070 5230947 200 µM 0.350053791214975 0.31864795103501 no 1088 0.363149164380228 1784 2835538 SGTC_2831 7999036 19.48 µM 0.348126925664281 0.319325195871353 no 1089 0.363872431913893 1868 2988270 SGTC_1144 3486-0183 12.5 µM 0.347538669139395 0.319532073565409 no 1090 0.364093336472387 1722 6744069 SGTC_2938 9059746 27.26 µM 0.34686530214158 0.319768951815443 no 1091 0.364346257510576 1735 6471769 SGTC_1721 st082152 9.2685 µM 0.341933343976679 0.321506161272822 no 1092 0.366200527773727 1669 5296051 SGTC_2626 ethyl orsellinate 100 µM 0.339283248648574 0.322441236283864 no 1093 0.367198180347831 1684 75653 A natural product. SGTC_212 3807-4682 38.772 µM 0.338807460557423 0.322609235343798 no 1094 0.36737739032061 1807 3125501 YBL034C STU1 SGTC_2475 5812728 15.03 µM 0.337048661384649 0.323230575202658 no 1095 0.368040108765997 1677 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_720 r052-1644 49.9 µM 0.336560195173873 0.323403225751296 no 1096 0.368224233447736 1715 1422863 YOR257W CDC31 SGTC_487 nimodipine 119 µM 0.333919842321509 0.324337127810483 no 1097 0.369220023174198 1817 4497 L-type voltage-gated calcium channels inhibitor SGTC_1311 1190-0148 100 µM 0.333738251788709 0.324401397734566 no 1098 0.369288541064393 1830 1961333 SGTC_1393 3470-5649 58.2 µM 0.333564649743506 0.324462845202461 no 1099 0.369354048614425 1718 4108395 SGTC_2791 5663188 71.43 µM 0.331971653245664 0.325026918682269 no 1100 0.369955331889401 1825 54690634 SGTC_2038 4100038 30.985 µM 0.330601881948399 0.325512270010765 no 1101 0.370472612246641 1747 3596803 SGTC_378 3970-0959 8.33 µM 0.330071394981987 0.325700317127249 no 1102 0.370673008304619 1768 6615653 SGTC_2360 9040895 200 µM 0.329687648772242 0.325836375208679 no 1103 0.370817993644612 1696 4914414 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.329405172430679 0.325936542654995 no 1104 0.370924729361751 1751 368090 SGTC_2760 etidronate 98.04 µM 0.328432844233048 0.326281430848748 no 1105 0.371292206450804 1697 3305 A chelator and antioxidant. SGTC_1539 benzyladenosine 56 µM 0.326649921966203 0.326914225491046 no 1106 0.371966340306272 1727 92208 A nucleotide analog. SGTC_3259 9138485 49.47 µM 0.326348350194648 0.327021308618677 no 1107 0.372080405328543 1841 17646153 SGTC_2923 7992654 58.14 µM 0.326346177380811 0.327022080200477 no 1108 0.372081227203698 1725 2985126 SGTC_261 5-fluorouridine 15.376 µM 0.32403263305621 0.327844055384801 no 1109 0.37295666417721 1825 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1643 st009866 20.2 µM 0.323467377279792 0.328045011179927 no 1110 0.373170654919186 1827 3156273 YOR207C RET1 SGTC_2439 5492030 7.2 µM 0.32315095932919 0.328157523624238 no 1111 0.373290459392169 1867 5722370 SGTC_799 1310-0557 151 µM 0.323045410008304 0.328195058503648 no 1112 0.3733304259715 1769 5354492 SGTC_1362 1611-0397 101 µM 0.322879234976273 0.328254156286328 no 1113 0.373393351426861 1711 27816 SGTC_1466 k213-0079 57.5 µM 0.322579776197666 0.328360665386495 no 1114 0.373506755926585 1745 3657981 SGTC_2330 7979373 200 µM 0.321913840953937 0.328597569900761 no 1115 0.373758983659533 1623 1863007 SGTC_166 k072-0058 166.424 µM 0.321592438984043 0.328711932372307 no 1116 0.373880736306628 1850 5846229 SGTC_3050 9093513 49.47 µM 0.318717236254024 0.329735710569542 no 1117 0.374970471564636 1726 25236664 SGTC_2108 5365811 200 µM 0.315417733190901 0.330912143637963 no 1118 0.376222252185098 1823 780283 SGTC_592 k241-0073 46.5 µM 0.314484624130227 0.331245146066911 no 1119 0.37657649634695 1848 4230158 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.313927506684216 0.331444030501718 no 1120 0.376788049186923 1772 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3256 9138902 49.47 µM 0.31351495110849 0.331591338674502 no 1121 0.376944731752204 1838 17228773 SGTC_2733 amorolfine 100 µM 0.310040027198506 0.332833135964096 no 1122 0.37826525887663 1870 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1336 1486-0901 104 µM 0.309837744378543 0.332905480340156 no 1123 0.378342173592798 1800 5006114 SGTC_815 1582-0027 36.9 µM 0.309379863235066 0.33306925980843 no 1124 0.378516293170539 1803 3128206 SGTC_1730 st033808 45.1 µM 0.308498536015205 0.333384591284755 no 1125 0.378851507024655 1757 1045166 SGTC_2327 6189656 200 µM 0.307190504223531 0.33385281115424 no 1126 0.379349186434931 1864 5349088 SGTC_2804 7954240 19.48 µM 0.306976055453622 0.333929599425162 no 1127 0.379430798921309 1855 828705 SGTC_2790 5423970 71.43 µM 0.303685640704103 0.335108677711522 no 1128 0.380683699360558 1883 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1735 st034310 56.75 µM 0.300230642486513 0.336348483406554 no 1129 0.382000616620917 1866 871153 SGTC_3317 9138495 8.753 µM 0.298520138973983 0.336962947787794 no 1130 0.382653103872662 1790 17020139 SGTC_2252 omeprazole 400 µM 0.297861394379075 0.337199704890841 no 1131 0.382904477020114 1861 4594 A proton pump inhibitor. SGTC_95 0471-0001 561.058 µM 0.297040968700178 0.337494661399301 no 1132 0.38321761570174 1698 4015405 SGTC_1289 0976-0073 69.1 µM 0.296951662611916 0.337526774435605 no 1133 0.383251706507561 1846 3391136 SGTC_469 w7 172 µM 0.296357461837831 0.337740469616718 no 1134 0.383478553728299 1838 45115570 A P450 inhibitor. SGTC_1791 st048313 56.1 µM 0.296008839249342 0.337865870733471 no 1135 0.383611665499673 1908 1204976 SGTC_885 0865-0106 16.8 µM 0.294682408175933 0.338343158380752 no 1136 0.384118251494693 1723 2793380 SGTC_1493 4348-0038 111 µM 0.294247216311622 0.338499809450025 no 1137 0.384284501664011 1836 800424 SGTC_1266 0828-0227 32.9 µM 0.293665854933252 0.338709119102984 no 1138 0.384506624110096 1845 3913820 SGTC_1400 3771-8998 51.5 µM 0.292626404652824 0.33908348031128 no 1139 0.384903864405159 1843 670767 SGTC_661 1304-0007 33.6 µM 0.290937587437861 0.339692051785976 no 1140 0.385549526750274 1772 3117130 SGTC_190 3970-0790 3.722 µM 0.29037211039325 0.33989591703654 no 1141 0.385765788836789 1885 2832352 SGTC_3093 9117344 49.47 µM 0.289678678728427 0.340145976288708 no 1142 0.386031034594001 1813 24824913 SGTC_1233 0325-0408 14.2 µM 0.287727916354652 0.340849820032701 no 1143 0.386777509544515 1865 12874 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.287481789465245 0.340938663143501 no 1144 0.386871721812106 1815 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1437 4092-1038 11.6 µM 0.287325918234072 0.340994931713257 no 1145 0.386931389534064 1799 3977136 SGTC_1348 1493-0373 93.8 µM 0.287008691627135 0.341109459518604 no 1146 0.387052832568361 1831 3010129 SGTC_1973 st070275 50.2 µM 0.286970177184538 0.341123365321942 no 1147 0.387067577704902 1908 17118334 SGTC_2189 6047310 154.431 µM 0.286946063542121 0.341132071764961 no 1148 0.387076809622103 1804 711535 SGTC_577 r071-0003 38.6 µM 0.286264603705847 0.341378153798329 no 1149 0.387337733172877 1759 4568517 YMR134W ERG29 SGTC_3217 9129673 49.47 µM 0.284797179890217 0.341908284285382 no 1150 0.387899766458521 1810 17248312 SGTC_130 0136-0219 337.655 µM 0.284329917300155 0.342077155933735 no 1151 0.3880787805709 1938 234244 SGTC_2424 5537928 59.2 µM 0.282447378073909 0.342757837238478 no 1152 0.388800245352984 1752 5382802 SGTC_1880 MG-132 525 µM 0.281380757536276 0.343143728648226 no 1153 0.3892091877083 1900 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1314 1222-0010 41.1 µM 0.281078558923848 0.343253090500045 no 1154 0.389325073002783 1835 3526027 SGTC_1188 1403-0014 4.57 µM 0.279931998466068 0.343668135537182 no 1155 0.389764838508819 1814 9614867 SGTC_1030 k029-0042 36.7 µM 0.279730854270039 0.343740967459611 no 1156 0.389842002328924 1824 6080581 SGTC_2446 5162541 200 µM 0.279087934005333 0.343973800130666 no 1157 0.39008867132908 1772 1549321 SGTC_2702 st077768 96.8 µM 0.277521484948614 0.344541335040523 no 1158 0.39068985542656 1777 6484119 SGTC_2895 9054447 58.44 µM 0.276370331481733 0.344958628878546 no 1159 0.391131820840994 1816 2697450 SGTC_2207 7258803 200 µM 0.275265940409106 0.345359148642475 no 1160 0.391555964830022 1894 3666799 SGTC_2582 agaric acid 100 µM 0.275214550911062 0.345377789839509 no 1161 0.39157570423131 1754 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1663 st014140 55.4 µM 0.272975322090187 0.346190418815099 no 1162 0.392436092760744 1872 4207120 SGTC_505 gw-5074 63.9 µM 0.272698550465341 0.34629091011079 no 1163 0.392542474525042 1898 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_224 benfluorex 43.875 µM 0.271601604335354 0.346689299874698 no 1164 0.392964182866227 1922 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.269494304654543 0.347455106182563 no 1165 0.393774662191468 1818 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1231 0242-0792 125 µM 0.266676512154381 0.348480083392288 no 1166 0.394859119888547 1799 3707635 SGTC_3005 9076496 71.4286 µM 0.266216793064816 0.348647412317934 no 1167 0.395036125277356 1935 21368410 SGTC_1403 3909-7815 62.9 µM 0.266070446500257 0.348700685839888 no 1168 0.395092477562453 1833 6615483 SGTC_2265 7929201 200 µM 0.264547682027148 0.349255184056205 no 1169 0.39567896404575 1735 1265108 SGTC_2119 5528445 120.635 µM 0.263794862088544 0.349529434292321 no 1170 0.395968996923523 1937 791935 SGTC_2124 5246320 200 µM 0.26279693642599 0.349893096943087 no 1171 0.396353548473459 1874 579342 SGTC_1896 st058441 89 µM 0.260945649003717 0.350568105051562 no 1172 0.397067210591845 1809 688759 SGTC_1692 fluoroquinolonic acid 71 µM 0.26030088016143 0.350803308727627 no 1173 0.397315846864501 1900 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2312 7706453 155.7 µM 0.259416018587151 0.35112618833966 no 1174 0.397657135804218 1820 976098 SGTC_3297 9117502 71.43 µM 0.259198821627278 0.351205458385983 no 1175 0.397740920124984 1913 7453720 SGTC_3222 9128301 49.47 µM 0.258631408702785 0.351412576765068 no 1176 0.39795982345927 1824 4911358 SGTC_814 3342-0569 96 µM 0.257506214064062 0.351823428385869 no 1177 0.398394009441905 1870 4346283 SGTC_659 k018-0002 107 µM 0.255879058333112 0.352417871262067 no 1178 0.39902211273241 1977 6797879 YHR007C ERG11 SGTC_1238 0333-0287 48.8 µM 0.254582759763178 0.352891701500753 no 1179 0.399522688124666 1847 7226 SGTC_2829 7992743 58.44 µM 0.253653533654614 0.353231497877288 no 1180 0.399881617454146 2041 16462845 SGTC_2137 5261020 140 µM 0.253180612192955 0.35340447921696 no 1181 0.400064323888947 1856 763655 SGTC_520 3584-0023 682 µM 0.252857943217883 0.353522519815687 no 1182 0.400188994985008 1799 1340790 SGTC_1136 pergolide 1.05886 µM 0.252511595647422 0.35364923832973 no 1183 0.400322826207914 1835 47811 A dopamine receptor agonist. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.251851221599202 0.353890894943352 no 1184 0.400578031970674 1818 2374 Ca(2+)-ATPase inhibitor. SGTC_331 k048-0133 24.5 µM 0.249508730131902 0.354748578150648 no 1185 0.401483644369756 1831 6813582 SGTC_982 1491-0518 27.5 µM 0.247862948657481 0.355351607932595 no 1186 0.402120224083893 1873 3091256 SGTC_81 0411-0046 9.971 µM 0.24745974518335 0.355499400789467 no 1187 0.402276220763457 1898 12925265 SGTC_1627 st003713 25.6 µM 0.246686132582899 0.355783026675526 no 1188 0.40257556977546 1833 16195070 YER133W GLC7 SGTC_3244 9134489 49.47 µM 0.246310968757701 0.355920599955456 no 1189 0.402720759813473 1842 16584271 SGTC_2326 6164455 177.58 µM 0.24490832433638 0.356435118391119 no 1190 0.403263708028345 1846 2888790 SGTC_858 0438-0351 2.77 µM 0.244359493495192 0.356636511889314 no 1191 0.403476205237021 1847 2799119 SGTC_2043 5101342 149 µM 0.242359745759065 0.357370657215156 no 1192 0.404250711446676 1894 678451 SGTC_694 1315-0438 43.2 µM 0.241756047510896 0.35759239021736 no 1193 0.404484598874941 1926 6793154 SGTC_1799 st045822 46.1415 µM 0.24085002710923 0.357925253658048 no 1194 0.404835677317251 1984 3674992 SGTC_1901 st060216 58.6 µM 0.240658405603464 0.35799566746238 no 1195 0.404909939531905 1825 688792 SGTC_1092 toremifene 6.32 µM 0.239242755757018 0.358516015881837 no 1196 0.405458675398053 1987 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_638 3970-0837 4.09 µM 0.238693752677916 0.358717882941504 no 1197 0.405671530697972 1847 4118451 YLR208W SEC13 SGTC_2849 9019321 12.99 µM 0.237058690312756 0.359319324935941 no 1198 0.406305629663791 1887 16489627 SGTC_3153 9100258 49.47 µM 0.236714771532901 0.359445876599833 no 1199 0.406439037293348 1827 25236848 SGTC_1690 st023502 41.2 µM 0.235219026100487 0.359996444667288 no 1200 0.407019369766369 1994 24207482 SGTC_3191 9110352 49.47 µM 0.234761966744326 0.360164741395324 no 1201 0.407196744468564 1901 17122424 SGTC_1006 4099-6547 255 µM 0.234731736182598 0.36017587373843 no 1202 0.407208476957375 1961 3146833 SGTC_2324 6149169 200 µM 0.234655550024527 0.360203929662692 no 1203 0.407238045194264 1981 2888231 SGTC_548 1436-0017 110 µM 0.233752841984932 0.360536413575031 no 1204 0.407588430986308 1991 9677137 SGTC_2700 st077718 96.8 µM 0.231177427331472 0.361485564921282 no 1205 0.408588482725217 1841 904970 SGTC_1397 3532-0190 20.1 µM 0.229912836033378 0.361951933993753 no 1206 0.40907975089006 1909 5322280 SGTC_1662 st014054 52 µM 0.228672795180783 0.362409448245116 no 1207 0.409561620429401 2007 2838777 SGTC_2364 9055074 200 µM 0.226827793154644 0.363090527169582 no 1208 0.410278825555243 1860 6470630 SGTC_84 0443-0269 128.823 µM 0.226297972384591 0.36328618963517 no 1209 0.410484837647103 1993 6150058 SGTC_865 0488-0499 301 µM 0.224618975042011 0.3639064777279 no 1210 0.411137851059 2050 9634651 SGTC_739 1486-1183 203 µM 0.224115137323279 0.364092685000997 no 1211 0.411333857083966 2037 4346692 SGTC_3043 9092303 49.47 µM 0.223028782233456 0.364494286947766 no 1212 0.411756552822887 1828 25236084 SGTC_2095 5432005 200 µM 0.221793489064831 0.364951128841821 no 1213 0.412237324105994 1915 783734 SGTC_2555 cholic acid 100 µM 0.219398410994337 0.365837433702924 no 1214 0.41316985386059 1939 6708657 Influences liver metabolism. SGTC_2231 micatex 6.853 µM 0.2193938961235 0.365839105120705 no 1215 0.413171612201517 1963 20737 An antifungal of unknown mechanism. SGTC_1259 0671-0132 43 µM 0.218693204059347 0.366098534125358 no 1216 0.413444521614247 1881 X1259 SGTC_3260 9137109 49.47 µM 0.217655158498508 0.366482979696142 no 1217 0.413848902165448 2035 17478346 SGTC_2256 7954252 200 µM 0.215663092475286 0.367221126784461 no 1218 0.414625186064574 1901 2972920 SGTC_2979 9012552 45.46 µM 0.214776959672476 0.367549635475836 no 1219 0.41497060860948 2075 17100905 SGTC_677 0929-0063 136 µM 0.212804000409489 0.368281402256605 no 1220 0.415739921668797 1977 1539583 SGTC_3066 9117245 49.47 µM 0.212219044206237 0.368498453390739 no 1221 0.415968074988505 1979 17176980 SGTC_2181 6316240 54.2555 µM 0.211912919826554 0.36861205921469 no 1222 0.416087485467588 1875 12779990 SGTC_463 ikarugamyin 104 µM 0.211322813329258 0.3688310860464 no 1223 0.416317691204341 2024 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3125 9127534 49.47 µM 0.210741848701425 0.369046761362205 no 1224 0.4165443586632 2075 1639235 SGTC_3206 9114350 49.47 µM 0.208810453707711 0.369764061891764 no 1225 0.417298105172469 2042 17087243 SGTC_1936 st074407 74.3 µM 0.205718604479349 0.370913286386313 no 1226 0.418505362554823 1857 809813 SGTC_752 1896-0090 130 µM 0.205642419557875 0.370941618519738 no 1227 0.418535119804598 1933 772567 SGTC_411 enrofloxacin 100 µM 0.205222705389779 0.371097717036573 no 1228 0.418699065314899 2088 71188 A bacterial gyrase inhibitor. SGTC_1447 4239-0816 81.9 µM 0.204961288647639 0.371194952890906 no 1229 0.41880118504481 1878 1341554 SGTC_1104 tacrolimus 29.8 µM 0.204178960090643 0.371485994778424 no 1230 0.419106826217739 1949 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2725 haloperidol 53.21 µM 0.202906672678324 0.371959468042775 no 1231 0.419603989364112 2037 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1029 k015-0030 64.7 µM 0.202647061295558 0.372056104502125 no 1232 0.419705451741781 1969 2208316 SGTC_326 k292-0812 17.5 µM 0.202048725006664 0.372278856931849 no 1233 0.419939316284261 2051 3579357 SGTC_1423 4048-0112 5.59 µM 0.20096276225995 0.372683255171063 no 1234 0.420363845715118 2050 X1423 SGTC_104 0074-0074 590.992 µM 0.20072178101697 0.372773012462329 no 1235 0.420458063763151 2060 3943124 SGTC_3283 9109332 35.8195 µM 0.199390794248712 0.37326888394922 no 1236 0.420978530517751 1988 17027281 SGTC_1101 ebselen 5.29 µM 0.199116105629686 0.373371247911112 no 1237 0.421085961504406 2074 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_403 arphamenine a 50 µM 0.198635153081243 0.373550498581917 no 1238 0.421274076661477 1967 5487158 An arginine aminopeptidase inhibitor. SGTC_1399 3562-5772 25 µM 0.197341617211716 0.374032734129841 no 1239 0.42178010690197 1968 23847490 SGTC_2394 5221648 200 µM 0.197185640902262 0.374090896084425 no 1240 0.421841133458927 2023 788586 SGTC_2421 5690543 90.72 µM 0.196118805058191 0.374488784934832 no 1241 0.422258588880605 1950 3397993 SGTC_1371 2421-0008 32.7 µM 0.196056383788451 0.374512069818305 no 1242 0.422283017182474 1918 2827552 SGTC_2183 6420625 130.508 µM 0.195401170187156 0.374756510457174 no 1243 0.4225394502958 2004 2897619 SGTC_3280 9140961 49.47 µM 0.194898077250005 0.374944233580847 no 1244 0.422736369731169 1907 4901226 SGTC_1850 st056238 17 µM 0.194697800033496 0.375018972881761 no 1245 0.422814767136858 2065 5393177 SGTC_1295 1013-0063 9.78 µM 0.194649871723997 0.375036859428305 no 1246 0.422833528861249 2088 6826038 SGTC_1274 0865-0114 173 µM 0.194606177511356 0.375053166070464 no 1247 0.422850633284372 1968 870624 SGTC_3065 9113888 49.47 µM 0.194472265882396 0.375103143164921 no 1248 0.422903054889015 2018 16648368 SGTC_285 1486-1325 46 µM 0.193651158664761 0.375409634013791 no 1249 0.423224518759871 2051 22310230 SGTC_2980 9014342 25.29 µM 0.190708062795178 0.376508834621966 no 1250 0.424377160717565 1970 2996599 SGTC_340 k038-0059 454 µM 0.190028527942363 0.376762773064701 no 1251 0.424643387877335 1986 23733424 SGTC_510 ag-490 170 µM 0.189720660509156 0.37687783899381 no 1252 0.424764015048752 2099 5328779 SGTC_878 0828-0289 13.7 µM 0.189486497409993 0.376965365137472 no 1253 0.424855768452429 1925 745350 YLR208W SEC13 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.188906563626116 0.377182161635015 no 1254 0.425083024585521 2045 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1578 josamycin 24.2 µM 0.187176291855809 0.377829218527669 no 1255 0.425761206339009 1903 5282165 A P450 substrate. SGTC_2836 9010338 19.48 µM 0.186600378438192 0.37804466475385 no 1256 0.425986985004084 1837 2994051 SGTC_2988 9073640 71.4286 µM 0.184790834721873 0.378721852237122 no 1257 0.426696548444281 2010 9102229 SGTC_2561 acetosyringone 100 µM 0.183372080161221 0.379253054931757 no 1258 0.427253040608452 2124 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1937 st074714 47.2 µM 0.182678364238722 0.379512875519287 no 1259 0.427525196456933 1855 17250970 SGTC_3186 9110464 49.47 µM 0.182124280330167 0.379720438189305 no 1260 0.427742597216382 2078 17018021 SGTC_1379 2144-0755 36.5 µM 0.182057918222741 0.379745300100037 no 1261 0.427768636572873 2095 5392327 SGTC_803 4488-1585 147 µM 0.181825643305546 0.379832323527186 no 1262 0.427859779756542 2071 747204 SGTC_1876 myriocin 605 nM 0.181360053766462 0.38000677823584 no 1263 0.428042485683777 2104 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2359 9039622 200 µM 0.180663866028679 0.380267682797839 no 1264 0.428315711370403 2029 6463596 SGTC_1803 st050068 52.4 µM 0.17858332797115 0.381047713254123 no 1265 0.429132443193198 2070 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.1779636195404 0.381280146508561 no 1266 0.429375773505457 2076 91467 include heat shock SGTC_1614 st002383 48.6 µM 0.177147710183663 0.381586233902112 no 1267 0.429696183593102 2135 1947235 SGTC_639 0833-0042 114 µM 0.175398319537872 0.38224276507737 no 1268 0.430383330466737 1950 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1384 3089-0840 101 µM 0.171938537794914 0.383542186922649 no 1269 0.431742924470502 2098 1069836 SGTC_2362 9071156 126 µM 0.171907284153625 0.383553931134559 no 1270 0.431755209957093 2078 653133 SGTC_3094 9117742 49.47 µM 0.171688516212731 0.383636140776318 no 1271 0.431841207243556 2108 17149698 SGTC_2844 9010103 25.97 µM 0.170509581086917 0.384079256631431 no 1272 0.432304700039718 1979 2480525 SGTC_2406 ethylparaben 405.7 µM 0.170272894321749 0.38416823626807 no 1273 0.432397763579059 1736 8434 A possible steroid mimic. SGTC_1374 2889-5571 141 µM 0.169607361381666 0.384418468341762 no 1274 0.432659466444471 1982 2853281 SGTC_2030 5175110 200 µM 0.169175828310203 0.384580745138104 no 1275 0.432829170972369 2050 2831986 SGTC_536 3852-0578 10.6 µM 0.167533881674896 0.38519837921331 no 1276 0.433474995261618 2110 2869208 SGTC_1816 st051957 91.6 µM 0.163228746682819 0.38681917695733 no 1277 0.435169166574882 2039 674121 SGTC_1090 efavirenz 20.7 µM 0.162579423220799 0.387063806508224 no 1278 0.435424794654068 2048 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1503 4585-0012 61.3 µM 0.1615972281554 0.387433929098424 no 1279 0.435811520117533 2084 2922052 SGTC_2657 nystatin 74.44 µM 0.15970305130563 0.388148004381309 no 1280 0.436557498581072 2088 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3228 9131799 49.47 µM 0.157862936339247 0.388842061494666 no 1281 0.437282402151778 2043 17015818 SGTC_160 3453-0671 289.699 µM 0.157282003658235 0.389061252308751 no 1282 0.437511301366003 2064 5322268 SGTC_3190 9110366 49.47 µM 0.157198623639921 0.389092715194359 no 1283 0.437544156496114 2132 17123768 SGTC_42 0133-0086 60.653 µM 0.157040601126344 0.389152345915473 no 1284 0.437606424996948 2064 162923 Model of phenazepam hydroxylation. SGTC_298 1391-0729 10 µM 0.157035889436166 0.389154123939451 no 1285 0.437608281654125 2007 3237558 SGTC_2670 beta-carotene 100 µM 0.156787158781365 0.389247989319967 no 1286 0.437706296744913 2109 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_940 3232-1287 54.8 µM 0.156623028785974 0.389309931845574 no 1287 0.4377709760953 2156 1585493 YIL048W NEO1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.155229798791863 0.389835848829902 no 1288 0.438320078488027 2129 229346 A bile salt which induces apoptosis. SGTC_2168 5727979 200 µM 0.153398681470568 0.390527366396851 no 1289 0.439041942307682 2130 695210 SGTC_2693 st077581 40.7 µM 0.153058762360491 0.390655774315297 no 1290 0.439175967745882 2179 25238761 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.152586530028015 0.390834184695426 no 1291 0.439362174040774 1965 5711223 A potent inhibitor of glutathione S-transferases. SGTC_31 0508-1974 57.237 µM 0.151997620074879 0.391056708324693 no 1292 0.439594406373716 2110 6810525 SGTC_675 1309-0189 238 µM 0.151402236981121 0.391281714135556 no 1293 0.439829212474761 2015 4246530 SGTC_909 3448-9333 149 µM 0.150177685623078 0.391744608078556 no 1294 0.440312215258507 2015 3344074 SGTC_1558 st069300 45.6 µM 0.14903528085553 0.39217658794291 no 1295 0.440762896869815 2150 24208000 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.148564330185204 0.392354708211287 no 1296 0.440948710488512 2131 94937 An inhibitor of serotonin biosynthesis. SGTC_169 k015-0017 16.025 µM 0.148525226246932 0.392369498893738 no 1297 0.440964139535119 2120 1840002 SGTC_408 cantharidin 100 µM 0.148386979895374 0.392421790471342 no 1298 0.44101868742933 2052 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2036 5160441 105 µM 0.148075978076773 0.392539433771791 no 1299 0.441141403575898 2065 134534 YIL048W NEO1 SGTC_8 0354-0001 70 µM 0.147392410548051 0.392798042770449 no 1300 0.441411147802564 2060 4993152 SGTC_2274 7947094 46.08 µM 0.146054386271167 0.393304384401152 no 1301 0.441939227334308 2189 2971028 SGTC_2428 5615643 7.78 µM 0.141508514150021 0.395025999103645 no 1302 0.443734117203606 2111 2253075 SGTC_2949 9072542 2.23 µM 0.141361087787669 0.39508186700487 no 1303 0.443792346486882 2051 16457352 SGTC_3019 9081971 49.47 µM 0.14051645891861 0.395401984563002 no 1304 0.444125974584164 2155 16451803 SGTC_3240 9133527 49.47 µM 0.140330240967442 0.395472571380655 no 1305 0.444199535943214 2048 17617455 SGTC_1661 st013063 9.66 µM 0.14028665869489 0.395489091947753 no 1306 0.444216752451559 2118 721395 SGTC_3084 9116877 49.47 µM 0.139500076632446 0.395787290888019 no 1307 0.44452749769395 2171 27241325 SGTC_1429 4049-0205 9.46 µM 0.135190822226418 0.397422038618923 no 1308 0.446230501640223 2161 22774478 SGTC_2044 5102272 200 µM 0.13475911929793 0.397585908191117 no 1309 0.446401164498947 2078 592666 SGTC_3270 9137563 49.47 µM 0.134575558291167 0.3976555913613 no 1310 0.446473733721017 2137 17015724 SGTC_2557 derrustone 83.84 µM 0.134052521601905 0.397854163713583 no 1311 0.446680521477881 1979 629853 An antioxidant. SGTC_790 1575-0012 79.1 µM 0.133646767681588 0.39800822756405 no 1312 0.446840950315452 2187 378741 YLR208W SEC13 SGTC_3048 9093155 49.47 µM 0.133509442267763 0.39806037331807 no 1313 0.446895248636343 2184 25236002 SGTC_3288 9119690 36.221 µM 0.132747716184491 0.398349652023331 no 1314 0.447196452358629 2050 17595618 YKL019W RAM2 SGTC_950 1165-0508 94.1 µM 0.132627687867984 0.39839523996005 no 1315 0.44724391705208 2043 6148369 SGTC_470 aa-861 153 µM 0.132299254171964 0.398519989399241 no 1316 0.447373798637733 2034 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_642 0335-0876 158 µM 0.131629414733297 0.398774447599319 no 1317 0.447638709180763 2071 6812350 SGTC_989 1501-0895 10.3 µM 0.13117167413383 0.398948358578726 no 1318 0.447819751543768 2193 2830112 SGTC_1794 st048918 76.9 µM 0.130867440957266 0.399063958049241 no 1319 0.447940085739494 2176 672303 SGTC_402 epigallocatechin gallate 10 µM 0.130822372642037 0.399081083408663 no 1320 0.447957912143453 2031 65064 An antioxidant. SGTC_2290 7904846 200 µM 0.13055304980453 0.399183426546864 no 1321 0.448064442781433 2049 2962154 SGTC_332 4112-0506 40.9 µM 0.128728896705627 0.399876789924792 no 1322 0.44878608468861 2070 2790355 SGTC_1681 tripelennamine 100 µM 0.128645329086468 0.399908561685982 no 1323 0.448819148434587 2211 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1159 4092-0538 61.2 µM 0.127476791199875 0.400352900057157 no 1324 0.449281520623283 2180 717301 SGTC_1814 st052110 31.539 µM 0.126653544570239 0.40066601837814 no 1325 0.449607307849461 2174 674163 SGTC_2003 4023581 200 µM 0.12652004673633 0.400716799726716 no 1326 0.44966014077626 2077 16641307 SGTC_2283 7944793 200 µM 0.125361569824249 0.401157544062887 no 1327 0.450118655444366 2098 2970533 SGTC_493 zm226600 134 µM 0.125273603938674 0.401191015966721 no 1328 0.450153474272997 2135 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2826 7992541 19.48 µM 0.124521348741599 0.401477286226318 no 1329 0.450451249037819 2207 2985066 SGTC_3334 9142812 21.919 µM 0.124484892494876 0.401491160973765 no 1330 0.450465680688735 2144 45283678 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.12428647548342 0.401566677943744 no 1331 0.450544227636002 2205 16725076 SGTC_1986 st071812 45 µM 0.122993642659948 0.402058816460842 no 1332 0.451056066083492 2186 11838594 SGTC_2802 7925815 54.55 µM 0.122671133782146 0.402181609115281 no 1333 0.451183761545832 2110 1262923 SGTC_3355 9151058 44.0485 µM 0.121927223458592 0.402464883770706 no 1334 0.451478327636441 2204 17015728 SGTC_2796 7949634 45.45 µM 0.121810275731757 0.402509421122658 no 1335 0.451524637849721 2135 2971588 SGTC_228 caffeine 993.056 µM 0.121692676692441 0.402554207790766 no 1336 0.451571206641925 2201 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1293 1000-1278 195 µM 0.120954973660601 0.402835185334906 no 1337 0.451863349539235 2152 678847 SGTC_1910 st062352 60.4 µM 0.120428994996942 0.403035551611412 no 1338 0.452071661928903 2136 2245730 SGTC_2130 NSC 7 2.4545 µM 0.12031312122786 0.403079695981733 no 1339 0.452117555189184 2179 21448 SGTC_2581 avocatin a 64 µM 0.11900434327716 0.403578386089598 no 1340 0.452635957399675 2101 6710728 A skin care supplement. SGTC_479 n-linoleoylglycine 10 µM 0.118979974354648 0.403587672989661 no 1341 0.45264561061016 2068 6433346 An anti-infammatory. SGTC_979 1426-2828 121 µM 0.117034181255811 0.404329382085437 no 1342 0.453416483435184 2137 747872 SGTC_6 0844-0013 19.835 µM 0.11623867853237 0.404632715809761 no 1343 0.453731691733167 2201 1584900 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.114863148401896 0.405157355370405 no 1344 0.454276797513095 2155 5106787 A p450 inhibitor. SGTC_3137 9097352 49.47 µM 0.113620158515367 0.405631589559055 no 1345 0.454769453325383 2157 44120435 SGTC_1752 st044819 83.042 µM 0.113105577619974 0.405827956649136 no 1346 0.454973426535033 2115 441209 YML126C ERG13 SGTC_2504 purpurogallin 52.29 µM 0.112652183178082 0.406000994269985 no 1347 0.455153156066302 2044 5281571 An antioxidant. SGTC_2313 7726885 200 µM 0.111917051347852 0.406281595750969 no 1348 0.455444588261122 2118 726423 SGTC_2741 miltefosine 3.04 µM 0.111883542262073 0.406294387393017 no 1349 0.455457873017592 2159 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_399 oxolinic acid 75 µM 0.111509055315451 0.406437349541153 no 1350 0.455606342640283 2079 4628 A DNA gyrase inhibitor. SGTC_1271 0832-2808 169 µM 0.111508429184658 0.40643758857997 no 1351 0.455606590882177 2199 3663794 SGTC_1369 1866-0067 208 µM 0.110212561135659 0.406932388499108 no 1352 0.456120400308439 2191 3531355 SGTC_290 2043-6722 48.1 µM 0.109700893874741 0.407127798826557 no 1353 0.456323295743439 2189 773758 YLR208W SEC13 SGTC_2757 clomiphene 4.22 µM 0.109431242228008 0.407230790520512 no 1354 0.456430227413281 2223 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_407 eburnamonine 100 µM 0.108995796128239 0.407397119867631 no 1355 0.456602912337189 2075 3195 SGTC_2730 imipramine 71.33 µM 0.108636033934665 0.407534552483347 no 1356 0.456745589467789 2232 3696 A tricyclic antidepressant. SGTC_1324 1418-0026 34.4 µM 0.108630393988767 0.407536707087542 no 1357 0.456747826243362 2133 1372513 SGTC_1789 tunicamycin 25 nM 0.107430029926822 0.407995340538364 no 1358 0.457223915960965 2203 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2344 7990960 76.95 µM 0.106727471087226 0.408263831792521 no 1359 0.457502594150116 2119 140813 SGTC_2945 9067681 61.76 µM 0.106448400293788 0.408370493990439 no 1360 0.457613296654113 2219 16456930 SGTC_1196 1588-0294 184 µM 0.10538286263147 0.408777809984029 no 1361 0.458036006989233 2098 6144269 SGTC_2620 irigenin 100 µM 0.104549577940595 0.40909641286857 no 1362 0.458366613154528 2176 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_202 3594-0513 34.79 µM 0.104478134418014 0.409123731796476 no 1363 0.458394959755763 2232 708429 SGTC_1072 oxiconazole 14.9 nM 0.103188464254309 0.40961695803706 no 1364 0.458906697614273 2235 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1256 0570-0116 285 µM 0.102988400269561 0.409693484088262 no 1365 0.458986088620635 2124 410638 SGTC_1150 3909-7983 10.9 µM 0.101507599609247 0.410260008801407 no 1366 0.45957376255272 2093 23965914 SGTC_1904 st060225 78 µM 0.0982647192919236 0.411501322736769 no 1367 0.460861046243503 2232 66595 SGTC_2983 9022671 12.99 µM 0.0974861724936315 0.411799468302129 no 1368 0.461170157338559 2260 6405161 SGTC_1253 0550-0034 176 µM 0.0959216104928047 0.412398773307204 no 1369 0.461791415513738 2146 5969915 SGTC_274 sirtinol 40.1 µM 0.0953549686801846 0.412615875754355 no 1370 0.46201644141058 2068 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1568 digitonin 820 nM 0.0947658173296665 0.412841630827831 no 1371 0.462250419230869 2250 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_793 0488-0545 106 µM 0.0944884283758652 0.412947932625303 no 1372 0.46236058706899 2055 292548 SGTC_1047 2043-3044 82 µM 0.0926333199185471 0.413659016390256 no 1373 0.463097436039834 2187 669592 SGTC_1958 st076513 41.9 µM 0.0918210965186481 0.413970439971144 no 1374 0.463420091135016 2181 732122 YGL099W LSG1 SGTC_2592 piperlongumine 83.33 µM 0.0913517561451679 0.414150419647809 no 1375 0.463606547206407 2142 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1354 1498-1681 81 µM 0.0909172658230698 0.414317051320389 no 1376 0.463779165434206 2143 5754243 SGTC_1442 4112-3290 3 µM 0.0908924421497338 0.414326571929914 no 1377 0.46378902781292 2254 704353 SGTC_3224 9130643 49.47 µM 0.0907892360643256 0.414366155041672 no 1378 0.463830031551842 2199 17644395 SGTC_2162 5663267 200 µM 0.0907507499111875 0.414380916038321 no 1379 0.463845322184385 2238 6456493 SGTC_1020 4335-0961 93.3 µM 0.0896180321704806 0.414815413183689 no 1380 0.464295377233197 2052 669075 SGTC_3082 9117008 49.47 µM 0.087770439765265 0.41552435124374 no 1381 0.465029566358893 2114 41448529 SGTC_920 mycophenolic acid 780.421 nM 0.0866950708198995 0.415937106911212 no 1382 0.465456947291281 2186 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2078 5212016 200 µM 0.0851207522121406 0.41654154010427 no 1383 0.466082696150539 2276 1899708 SGTC_757 1066-0008 322 µM 0.0805548231173162 0.418295663384321 no 1384 0.467897997657773 2236 6842497 SGTC_844 0330-0132 15.3 µM 0.0797969814698827 0.418586966737928 no 1385 0.468199362554129 2258 2828079 SGTC_1460 k062-0059 9.15 µM 0.079494800913029 0.418703133028417 no 1386 0.468319533399071 2231 1373085 SGTC_1270 0831-1170 17.3 µM 0.0787276020788542 0.41899809661237 no 1387 0.468624645165047 2265 6764716 SGTC_3158 9100007 49.47 µM 0.0786115698855245 0.419042711273686 no 1388 0.468670792291594 2193 19297233 SGTC_2016 5121758 140 µM 0.0778415227008324 0.419338822648295 no 1389 0.468977058148373 2280 2795203 SGTC_1077 5-fluorocytosine 377 nM 0.0767748875754021 0.419749058399523 no 1390 0.469401314285636 2211 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0750284189982585 0.420420951261099 no 1391 0.470096050261216 2124 688788 SGTC_2171 5739187 198.077 µM 0.0750238520121503 0.420422708554588 no 1392 0.470097867104432 2253 2262761 SGTC_39 0986-0283 58.349 µM 0.0745826969009497 0.420592464517794 no 1393 0.470273370823418 2260 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3075 9116269 49.47 µM 0.0739914871868141 0.42081998446707 no 1394 0.470508579467407 2208 17015205 YNL244C SUI1 SGTC_2614 arthonioic acid 13.39 µM 0.0736856086442657 0.42093770853329 no 1395 0.470630275147223 2272 6710684 SGTC_16 erodoxin 22.806 µM 0.0723964944892462 0.421433929956625 no 1396 0.471143187234291 2257 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2726 cimetidine 79.27 µM 0.0723421569599619 0.421454848962734 no 1397 0.471164808080299 2277 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1338 1486-1223 76 µM 0.0722962880472674 0.421472507870933 no 1398 0.471183059338789 2236 3444526 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0719957486586888 0.421588215358366 no 1399 0.471302645575982 2255 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2484 5809818 12.04 µM 0.0718281186697658 0.421652755747315 no 1400 0.471369347573888 2225 2870548 SGTC_2865 9030313 51.95 µM 0.0716206071616986 0.421732654112736 no 1401 0.471451920022386 2261 42562754 SGTC_282 k297-0036 65.7 µM 0.0708360160021077 0.422034775134081 no 1402 0.471764133591927 2246 5061378 SGTC_363 0455-0021 3.06 µM 0.0705211345427325 0.422156038850566 no 1403 0.471889439746669 2256 4597466 SGTC_3167 9103034 49.47 µM 0.0695445360063948 0.422532182726064 no 1404 0.472278091917464 2259 5127859 SGTC_2448 5185112 27.17 µM 0.0689380397360129 0.422765814665766 no 1405 0.472519469599583 2197 5718189 SGTC_783 0848-0141 92.7 µM 0.0685379378673429 0.422919955101993 no 1406 0.472678710506112 2279 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0682191441313198 0.423042779786684 no 1407 0.47280559382919 2264 364106 SGTC_229 benomyl 22.8748 µM 0.0676878757879252 0.423247483192304 no 1408 0.473017050447636 2200 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1547 harmine 94.2 µM 0.0660564089702029 0.423876234187738 no 1409 0.473666457806889 2285 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2341 7987486 176.74 µM 0.0643192362403887 0.424545936239756 no 1410 0.474358018431368 2280 1258686 SGTC_2240 6690706 185.951 µM 0.0632955754438902 0.424940672569884 no 1411 0.474765569492448 2264 805876 SGTC_2961 9083290 32.55 µM 0.0629251696537095 0.425083524214706 no 1412 0.474913046036009 2307 17741490 SGTC_140 0062-0056 502.533 µM 0.06226871266946 0.425336719250048 no 1413 0.475174421891069 2291 3758964 SGTC_2431 5490079 200 µM 0.0613464243497329 0.425692497265293 no 1414 0.475541659557018 2255 5722345 SGTC_66 0109-0187 42.4 µM 0.060907885574249 0.425861687358495 no 1415 0.475716284663916 2317 759417 SGTC_1685 st024049 53.0905 µM 0.0604763038302089 0.426028206726469 no 1416 0.475888144051435 2231 1941139 SGTC_2659 sanguinarine 24.21 µM 0.0603092604884965 0.426092661446585 no 1417 0.475954663284943 2295 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2513 baicalein 25.65 µM 0.0587811255521995 0.426682393323719 no 1418 0.476563221044879 2247 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2068 5226020 147 µM 0.0583510924778558 0.426848379626725 no 1419 0.47673448544936 2265 1810509 SGTC_1038 k292-0204 154 µM 0.0575091349158945 0.427173400075216 no 1420 0.477069814771403 2298 4454212 SGTC_925 2064-1272 59.6 µM 0.0569602266035358 0.427385321509359 no 1421 0.477288439123336 2144 6815817 SGTC_594 1487-1584 10.8 µM 0.0567530681014068 0.427465306303406 no 1422 0.477370949935135 2281 5013332 SGTC_761 k216-0224 480 µM 0.0560784154849248 0.427725813246777 no 1423 0.47763966941134 2321 1340404 SGTC_2909 7941780 10.49 µM 0.0554152352028505 0.427981921033101 no 1424 0.477903829275555 2309 1243215 SGTC_217 ketoconazole 989 nM 0.0538956928303131 0.428568854037304 no 1425 0.478509134151819 2287 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_134 0269-0018 6.916 µM 0.0536602495689312 0.428659809681519 no 1426 0.478602926697782 2243 4378915 SGTC_3246 9135460 32.98 µM 0.0532569364465751 0.428815625044712 no 1427 0.478763595607834 2289 41446951 SGTC_1800 st050079 29.0735 µM 0.052925375416586 0.428943728127201 no 1428 0.478895683033898 2290 3645560 SGTC_2202 7226349 200 µM 0.0522459204369562 0.429206268108473 no 1429 0.479166371827708 2304 844334 SGTC_3185 9108267 49.47 µM 0.0518521184500602 0.429358446715792 no 1430 0.479323263427826 2226 4910486 SGTC_2711 st079103 59.1 µM 0.0516288345943053 0.429444735928671 no 1431 0.479412221644511 2279 54693780 SGTC_367 0335-0881 7.1 µM 0.0515499864559602 0.429475208009415 no 1432 0.479443635669094 2277 23828853 SGTC_2638 epoxomicin 18 µM 0.0505339885730153 0.429867893611433 no 1433 0.479848432514945 2321 9915668 A protesome inhibitor. SGTC_1768 st044301 37.178 µM 0.049140383042776 0.430406638259673 no 1434 0.480403710625275 2315 3931349 SGTC_1408 3909-7976 48.8 µM 0.0480006293029451 0.430847344404346 no 1435 0.48085787053774 2291 24152374 SGTC_2117 5521686 200 µM 0.0465391923389806 0.431412561064925 no 1436 0.481440248471868 2286 803312 SGTC_1911 st060208 74.3 µM 0.0435107401690793 0.432584273071879 no 1437 0.482647201609191 2307 688783 SGTC_1407 3909-7909 12.3 µM 0.0428694811183702 0.432832453449561 no 1438 0.48290278845761 2322 4411780 SGTC_23 0213-0011 39.996 µM 0.0421021228535542 0.433129471621213 no 1439 0.483208643940353 2315 627608 SGTC_2661 dactinomycin 12.96 µM 0.0418996881653713 0.433207833478346 no 1440 0.483289332494581 2339 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1173 0443-0020 122 µM 0.0411316557218773 0.433505160377211 no 1441 0.483595469166697 2296 5331295 SGTC_370 0180-0345 38.7 µM 0.0403368231644145 0.433812901978912 no 1442 0.483912298508288 2281 3989527 SGTC_2958 9077254 16.72 µM 0.0378412285952117 0.434779400973994 no 1443 0.484907136116295 2289 16457351 SGTC_2908 7930301 100 µM 0.0377176020955322 0.43482728948135 no 1444 0.484956420769807 2348 2223178 SGTC_633 0437-0093 97.7 µM 0.0372402635621152 0.435012202412249 no 1445 0.485146717591944 2338 2831118 SGTC_655 k060-0012 42 µM 0.0364929485762929 0.435301728218589 no 1446 0.485444650593507 2310 5994525 SGTC_542 3381-0244 89.3 µM 0.0358919019446583 0.435534611712263 no 1447 0.485684276510356 2345 1112843 SGTC_1133 3473-0247 50 µM 0.0357935470802671 0.435572722740557 no 1448 0.48572348922783 2259 711311 SGTC_1287 0971-0001 34.6 µM 0.035731540630551 0.435596749613283 no 1449 0.485748210408525 2335 4665869 SGTC_3209 9113616 49.47 µM 0.034632251318555 0.436022752501422 no 1450 0.486186492042458 2355 16649353 SGTC_2332 7982454 138.89 µM 0.0345986609034667 0.43603577082272 no 1451 0.486199884653135 2342 2981748 SGTC_1479 0549-0158 134 µM 0.0336410842595038 0.436406918891244 no 1452 0.486581680147256 2340 5440202 SGTC_1249 0481-0015 10.2 µM 0.0320248792967517 0.437033472203028 no 1453 0.487226105130387 2333 4227577 SGTC_2027 5150920 200 µM 0.0318259875748227 0.43711058739789 no 1454 0.487305411021453 2324 786715 SGTC_508 roscovitine 141 µM 0.0315895510181908 0.437202262753692 no 1455 0.487399688156096 2350 160355 A CDKinase inhibitor. SGTC_545 4218-0007 221 µM 0.0309066043370099 0.437467085817103 no 1456 0.487672011470718 2324 2840508 SGTC_3314 9135860 59.4275 µM 0.0296662728585371 0.437948114960048 no 1457 0.48816660521788 2335 25252478 SGTC_2978 9011784 42.97 µM 0.0288200206965994 0.438276363733067 no 1458 0.488504066652205 2346 2994934 SGTC_2785 7756463 72.73 µM 0.0284443411157147 0.438422097944601 no 1459 0.488653879698934 2342 2201551 SGTC_3328 9140624 29.0385 µM 0.0279296744316555 0.43862176180277 no 1460 0.48885912044841 2351 4904392 SGTC_3188 9110789 49.47 µM 0.0274251851871597 0.438817492506499 no 1461 0.489060305463259 2337 849217 SGTC_2540 epiandrosterone 100 µM 0.0270937310197698 0.438946097563273 no 1462 0.489192487424159 2363 441302 A steroid. SGTC_3154 9100113 49.47 µM 0.0254663284165124 0.439577627159627 no 1463 0.489841502901526 2333 25237525 SGTC_1066 ketoconazole 628 nM 0.0230205646886838 0.440527018604832 no 1464 0.490816934522877 2356 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_576 1073-0113 22.7 µM 0.0227539178773824 0.440630545778235 no 1465 0.490923283351745 2373 5439563 SGTC_71 0417-1750 47.813 µM 0.0219364195793785 0.440947969504096 no 1466 0.491249336567481 2372 6811472 SGTC_1960 st011366 51.8 µM 0.0205420420137104 0.441489475227684 no 1467 0.491805487232925 2369 3972846 SGTC_2193 5925765 200 µM 0.0200991016742691 0.441661513794356 no 1468 0.49198215838079 2353 877370 SGTC_1216 1165-0504 9.65 µM 0.018076549414155 0.44244721494134 no 1469 0.49278889287593 2371 6304004 SGTC_3257 9139206 32.98 µM 0.0179919592468086 0.442480080649458 no 1470 0.492822633982851 2368 4910041 SGTC_704 1310-0270 142 µM 0.0167192895129734 0.442974597027366 no 1471 0.493330279252784 2360 5718033 SGTC_3344 9148862 3.898 µM 0.0159923303099487 0.443257108683815 no 1472 0.493620255219918 2358 4905352 SGTC_17 0960-0276 49.807 µM 0.0153403602350859 0.443510502526987 no 1473 0.493880321727143 2377 6821114 SGTC_1636 st007707 68.9 µM 0.0146599916727689 0.443774958319595 no 1474 0.494151718973049 2372 403051 SGTC_2213 7173844 200 µM 0.0142039919368193 0.443952217115592 no 1475 0.494333617601869 2378 892728 SGTC_413 propylparaben 100 µM 0.0132744060909917 0.444313605674062 no 1476 0.494704433685372 2374 7175 A pharmaceutical preservative. SGTC_2383 9036125 200 µM 0.0105607896827448 0.445368823044853 no 1477 0.495786932795365 2382 79580 SGTC_2321 7390090 138.78 µM 0.0100034439267863 0.445585600788275 no 1478 0.496009269826081 2374 649046 SGTC_351 caspofungin 25 nM 0.00992591189861425 0.445615757898438 no 1479 0.4960401990946 2375 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_278 4092-0821 23.9 µM 0.009415648957332 0.445814239275899 no 1480 0.496243755034887 2376 877900 SGTC_1034 k072-0165 12.7 µM 0.00874806268256444 0.446073936565968 no 1481 0.496510072437592 2392 5835461 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.00792652731187078 0.44639355323223 no 1482 0.496837806231925 2381 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2008 4012253 172 µM 0.00711838948543679 0.446707991595416 no 1483 0.497160197448742 2388 603940 SGTC_1790 st045711 43.5 µM 0.00483545261160819 0.447596439940591 no 1484 0.49807094102577 2394 585119 SGTC_2133 5320837 200 µM 0.00414255083373116 0.447866148086767 no 1485 0.498347366050447 2397 2841355 SGTC_3164 9100705 49.47 µM 0.00377678866840834 0.44800852869447 no 1486 0.498493282898034 2402 17174235 SGTC_2797 7859098 81.82 µM 0.00357098442198921 0.448088645267512 no 1487 0.498575386359176 2393 972681 SGTC_1014 4130-3005 69.3 µM 0.00270347584405931 0.448426376863464 no 1488 0.49892147049555 2400 743608 SGTC_2567 aureobasidin a 60 nM 0.00172823276760157 0.4488060954265 no 1489 0.499310535221843 2394 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3133 9127736 49.47 µM 0.00160501132362623 0.448854076009314 no 1490 0.499359693397394 2401 27243420 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.000685589348702072 0.4492121087077 no 1491 0.499726489443236 2401 442882 SGTC_3262 9137218 49.47 µM 0 0.449479111427195 no 1492 0.5 2406 17650664 SGTC_3117 9124945 49.47 µM -0.000113779535603486 0.44952342507516 no 1493 0.499954608532701 2406 17592065 SGTC_225 nsc-122657 1.016 µM -0.000223714928251773 0.44956624214504 no 1494 0.499910750657108 2407 275685 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.000289433445402339 0.449591838134709 no 1495 0.499884532762879 2406 7104 SGTC_1221 2958-7315 257 µM -0.000536383747882359 0.449688021993071 no 1496 0.49978601385471 2411 4562705 SGTC_1972 st070201 17.4 µM -0.000773972591067317 0.449780562477604 no 1497 0.499691229640379 2408 2829099 SGTC_2351 9026858 72.31 µM -0.00232998585670203 0.450386694508822 no 1498 0.499070470970067 2411 1409300 SGTC_3144 9087057 49.47 µM -0.00427669517495779 0.45114518175847 no 1499 0.498293850675269 2412 17249618 SGTC_41 0478-0632 82.643 µM -0.00451837779495563 0.451239359934071 no 1500 0.498197434192219 2416 3750424 SGTC_1874 staurosporine 7.6 µM -0.00451893159238539 0.451239575739386 no 1501 0.498197213261265 2421 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1082 camptothecin 424.86 nM -0.00487291580101116 0.451377520231118 no 1502 0.498055995551641 2411 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1160 4092-0570 10.5 µM -0.0100244091999378 0.453385667369012 no 1503 0.496000906311553 2421 4994975 SGTC_1801 st050089 28.441 µM -0.0102341612106739 0.45346745818573 no 1504 0.495917231658945 2412 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_535 2293-4129 48.2 µM -0.0134309217210258 0.454714247033356 no 1505 0.494641998549214 2430 396118 YIL048W NEO1 SGTC_1341 1486-1360 280 µM -0.0148466267503622 0.45526653844497 no 1506 0.494077270452378 2433 3976547 SGTC_1091 telmisartan 47.6 µM -0.0148580021701388 0.455270976547751 no 1507 0.494072732816981 2468 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_891 0929-0073 133 µM -0.0168899385630336 0.456063822486211 no 1508 0.493262209743612 2487 5603632 SGTC_2939 9044578 71.43 µM -0.0176366211890164 0.456355216430661 no 1509 0.492964370865386 2439 2653634 SGTC_259 usnic acid 108.925 µM -0.0189302159663596 0.45686009908242 no 1510 0.492448387500511 2463 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_855 0428-0020 25 µM -0.0191963368514303 0.456963973207824 no 1511 0.492342239917291 2455 6812414 SGTC_2047 4141938 200 µM -0.0197079255981565 0.45716366828292 no 1512 0.492138184147785 2457 3807862 SGTC_67 0335-0847 266 µM -0.0205787936693592 0.457503630371642 no 1513 0.49179082854228 2469 4552207 YOR254C SEC63 SGTC_430 0958-0115 16.4 µM -0.0212155480234856 0.457752220829396 no 1514 0.49153685577244 2469 6833180 SGTC_2092 5303694 80.6725 µM -0.0229778871328609 0.458440328212191 no 1515 0.490833955901871 2448 1963699 SGTC_1708 st033234 31.827 µM -0.0230933245815897 0.45848540526927 no 1516 0.490787915239966 2499 674664 SGTC_2824 7998404 51.95 µM -0.0232241690477471 0.458536499243085 no 1517 0.490735729846405 2452 837851 SGTC_3097 9117246 49.47 µM -0.0236318210281917 0.458695689267681 no 1518 0.490573144862052 2440 16423892 SGTC_2337 9009472 200 µM -0.0249081371903826 0.459194139480727 no 1519 0.490064118354835 2458 5742383 SGTC_3315 9136395 68.55 µM -0.0255536427527898 0.459446258537291 no 1520 0.489806680853341 2453 16876844 SGTC_2860 9025725 38.96 µM -0.0277244436083168 0.460294240578447 no 1521 0.488940964007219 2471 40546248 SGTC_2869 9037858 32.47 µM -0.0282304036853184 0.460491910349932 no 1522 0.488739194124213 2446 27187042 SGTC_168 3970-0862 530.542 µM -0.0288164506255135 0.460720880862162 no 1523 0.488505490313214 2487 3135186 SGTC_2367 9070478 135.38 µM -0.0291362854545696 0.460845846904715 no 1524 0.488377948233015 2465 572802 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0293352825163438 0.460923601099701 no 1525 0.48829859381212 2458 803109 SGTC_532 1548-0774 215 µM -0.0298473305693389 0.461123680684125 no 1526 0.488094405614217 2515 5932993 SGTC_1606 st000094 49.2 µM -0.0299634907850581 0.461169070935531 no 1527 0.488048085110515 2452 1242210 SGTC_3310 9130229 44.1445 µM -0.030132988325103 0.46123530395101 no 1528 0.487980495895376 2536 7761258 SGTC_816 0325-0417 81.3 µM -0.0303597455111232 0.46132391347986 no 1529 0.48789007423694 2480 68101 SGTC_734 2023-0417 80 µM -0.0343107940035427 0.462868162491038 no 1530 0.486314658784218 2501 3935732 SGTC_2645 abamectin 100 µM -0.0361669568223438 0.463593829817451 no 1531 0.485574616689457 2476 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2929 9013348 24.6 µM -0.0371016323733312 0.463959287474503 no 1532 0.485201985240212 2518 2995952 SGTC_967 1306-0166 352 µM -0.0371300007516983 0.463970379972858 no 1533 0.485190675687267 2474 4437607 SGTC_3268 9137683 49.47 µM -0.038382874972335 0.464460302024585 no 1534 0.484691207356371 2466 1953228 SGTC_1118 chelidonine 707.474 nM -0.0389223190447129 0.464671262063336 no 1535 0.484476161012728 2475 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1889 st059080 5.18 µM -0.039119517098605 0.464748382658546 no 1536 0.484397550241971 2476 176925 Isolated from Daphnopsis sellowiana. SGTC_1763 st044482 94.5 µM -0.0394019657128391 0.464858845513317 no 1537 0.484284956357968 2536 88505 SGTC_1632 st005650 90 µM -0.0400944190439621 0.465129668592208 no 1538 0.484008925591736 2528 2759605 SGTC_605 1315-0399 119 µM -0.0406987146248732 0.465366025795209 no 1539 0.483768043164442 2535 24020461 SGTC_787 4152-0075 138 µM -0.0408088791966326 0.465409115614304 no 1540 0.483724130340922 2513 9566539 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0412071509691462 0.465564899190681 no 1541 0.483565376433792 2475 688662 SGTC_1545 lovastatin 49.4 µM -0.0443987747924492 0.466813488010163 no 1542 0.482293269130719 2506 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_500 h-89 112 µM -0.0450185405915215 0.467055983614659 no 1543 0.482046265340376 2493 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1143 3454-2408 5.08 µM -0.0451100999585342 0.467091809063448 no 1544 0.482009775508185 2469 X1143 SGTC_2051 5263410 176 µM -0.045585285600825 0.467277744494464 no 1545 0.481820398684859 2482 227584 SGTC_410 α-linolenic acid 100 µM -0.0460121810640112 0.467444790547023 no 1546 0.481650270554084 2590 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2636 apigenin dimethyl ether 100 µM -0.0463042163278081 0.467559068521136 no 1547 0.481533889386115 2557 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3337 9144342 33.5465 µM -0.0476947716450557 0.468103251118597 no 1548 0.480979750492766 2548 17682949 SGTC_1275 0867-0008 21.1 µM -0.0485790099446997 0.468449321706992 no 1549 0.480627398924652 2515 3422836 SGTC_2220 6782180 200 µM -0.0491238307267944 0.46866256395223 no 1550 0.480410306078559 2504 833803 SGTC_2311 7694451 200 µM -0.0491901529624963 0.468688523016233 no 1551 0.480383879282892 2535 2163142 SGTC_1891 st059073 26.2 µM -0.0494026527319303 0.468771698055252 no 1552 0.480299207085428 2511 688754 SGTC_1202 1988-0068 29.6 µM -0.0499786750242449 0.468997167152188 no 1553 0.480069690972965 2510 2850480 SGTC_3115 9123671 49.47 µM -0.0505960858425837 0.469238847760729 no 1554 0.479823690938762 2493 3286988 SGTC_1497 4476-2978 41.3 µM -0.0507805692155053 0.469311064529427 no 1555 0.479750187208863 2567 1528379 SGTC_864 0469-0573 172 µM -0.0511486123413621 0.469455139525919 no 1556 0.479603549806713 2500 689425 SGTC_1235 benzylparaben 21.5 µM -0.0515626726743365 0.469617233302589 no 1557 0.479438581322037 2536 7180 SGTC_1573 oleylamine 1.06 µM -0.0521695376553351 0.469854814140548 no 1558 0.479196802648674 2498 5356789 An amine of the fatty acid oleic acid. SGTC_1743 st037606 46.3785 µM -0.0524653378960095 0.469970620515005 no 1559 0.479078956815712 2531 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2543 pimpinellin 60.67 µM -0.0531380680860855 0.470234005145984 no 1560 0.478810950169084 2497 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0562054249067774 0.471435087746114 no 1561 0.477589079772969 2493 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1417 3966-0327 90.4 µM -0.0563569060644038 0.471494409931803 no 1562 0.477528743170472 2511 651118 SGTC_198 3454-2873 16.191 µM -0.056450506050003 0.471531065339735 no 1563 0.477491461529474 2521 710957 SGTC_3011 9081274 71.4286 µM -0.0567485381583272 0.471647781583446 no 1564 0.477372754213139 2533 6625322 SGTC_2594 a-mangostin 100 µM -0.0583602922749791 0.472279023586586 no 1565 0.476730821505204 2584 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_866 0495-0101 262 µM -0.0601632578668316 0.472985235829308 no 1566 0.476012804328302 2541 635694 SGTC_3192 9110362 49.47 µM -0.0608714899577304 0.473262670009333 no 1567 0.475730777522719 2504 16649480 SGTC_938 3126-1755 342 µM -0.060911512366968 0.473278348287029 no 1568 0.475714840464428 2513 1777771 SGTC_850 0388-0143 75.9 µM -0.0614703520595779 0.473497271052751 no 1569 0.475492312684934 2526 67273 SGTC_1487 3970-0795 2.82 µM -0.0628636532408945 0.474043124813977 no 1570 0.474937539042498 2568 3765103 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.0631003495029316 0.474135860206344 no 1571 0.474843297996171 2569 5379071 SGTC_3166 9102297 49.47 µM -0.0632813089530942 0.47420675938019 no 1572 0.474771249611769 2553 25237072 SGTC_2447 5741742 33.78 µM -0.0639798752465479 0.474480462446071 no 1573 0.474493125599111 2582 1776504 SGTC_3085 9117376 49.47 µM -0.0647461963376675 0.47478072615606 no 1574 0.474188040301088 2589 16480349 SGTC_3161 9100388 49.47 µM -0.0658704248036903 0.475221252774414 no 1575 0.473740493507902 2526 25236368 SGTC_2116 5511452 16.8835 µM -0.0660788255974001 0.475302917542268 no 1576 0.473657534362888 2605 870744 SGTC_2369 9071472 200 µM -0.0683750329394346 0.476202786467275 no 1577 0.47274354806752 2616 17296037 SGTC_1007 4101-0031 70 µM -0.068998535286686 0.476447154183414 no 1578 0.472495392697189 2527 1146276 SGTC_703 3875-0075 71.8 µM -0.0693816984239872 0.476597330754115 no 1579 0.472342898175963 2552 2850814 SGTC_624 k048-0052 28 µM -0.0705401602558028 0.477051397237194 no 1580 0.471881868440754 2587 6835531 SGTC_876 0720-0963 56.8 µM -0.0715323676148829 0.477440322933557 no 1581 0.471487032449225 2546 765861 SGTC_311 1315-0136 58 µM -0.0717491865062951 0.477525314532168 no 1582 0.471400755913631 2646 6759207 SGTC_2298 7976326 193.81 µM -0.0727692548902661 0.477925188373916 no 1583 0.470994868557433 2580 2235818 SGTC_2635 hydroquinidine 100 µM -0.0743712436555819 0.478553223723109 no 1584 0.470357494829014 2554 442912 An experimental heart treatment. SGTC_1916 st067606 49.2 µM -0.0748390044619612 0.478736612353375 no 1585 0.47017140387333 2618 19590279 SGTC_643 k048-0106 28.4 µM -0.0766992112413721 0.479465962545921 no 1586 0.469431416016153 2643 6763920 SGTC_1070 indatraline 8.81 µM -0.0793361139389704 0.480499957043197 no 1587 0.468382641024151 2564 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3027 9089541 49.47 µM -0.0799798811101551 0.480752414201899 no 1588 0.468126628625213 2640 9943819 SGTC_3054 9094397 49.47 µM -0.0807581572705902 0.481057630166458 no 1589 0.467817142495712 2575 2598354 SGTC_1074 carmofur 3.8 µM -0.0808409139914465 0.481090085462462 no 1590 0.46778423493587 2547 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1212 0520-0165 585 µM -0.0808676240171762 0.481100560551342 no 1591 0.467773613950979 2779 5403258 SGTC_210 3551-0445 56.827 µM -0.0809404764089547 0.481129131734987 no 1592 0.467744645014571 2662 2865180 YOR207C RET1 SGTC_1640 st009078 66.4 µM -0.084196246011723 0.482406073232564 no 1593 0.466450201420392 2592 690618 SGTC_1313 1220-0047 237 µM -0.0847229825824292 0.482612681260555 no 1594 0.466240812099228 2594 3528706 SGTC_2892 9047358 58.44 µM -0.0850539668381941 0.482742509467613 no 1595 0.466109243386648 2600 6466771 SGTC_226 1,3-diallylurea 8.28947 mM -0.0855797399124983 0.482948747129372 no 1596 0.465900252285127 2652 74537 YKL182W FAS1 SGTC_777 1315-0167 517 µM -0.0865990007722612 0.483348571300297 no 1597 0.465495130093108 2638 4221767 SGTC_1610 st001799 48.1 µM -0.0881042049157359 0.48393904633664 no 1598 0.464896927169609 2561 621897 SGTC_1062 mesoridazine 14.2 µM -0.0881915229916911 0.483973301351256 no 1599 0.464862227369009 2546 4078 A neuroleptic. SGTC_2801 7907800 81.82 µM -0.08859927504698 0.484133264667396 no 1600 0.464700192124756 2629 6620925 SGTC_389 tpck 16.7 µM -0.0899587344017913 0.48466660616248 no 1601 0.464160003498456 2607 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2918 7977171 22.06 µM -0.0903006146157103 0.484800736560312 no 1602 0.464024165877768 2558 2236483 SGTC_269 exalamide 29 µM -0.0905387984902589 0.484894184628874 no 1603 0.463929531902299 2596 3316 A derivative of salicylamide. SGTC_1130 3454-2858 15.9 µM -0.0910976732082682 0.485113454454367 no 1604 0.463707490733905 2683 715628 YIL048W NEO1 SGTC_3001 9076041 71.4286 µM -0.0911459719183237 0.485132404261922 no 1605 0.463688302165104 2577 16004211 SGTC_3205 9113483 49.47 µM -0.091691894090863 0.485346596988038 no 1606 0.463471418919886 2688 17018033 SGTC_806 3966-4455 5.86 µM -0.0917883606645697 0.485384446118122 no 1607 0.463433095932737 2595 714982 SGTC_316 k060-0003 58.6 µM -0.0918817770462754 0.485421098616014 no 1608 0.463395985009641 2701 6152314 SGTC_2674 ligustilide 100 µM -0.0926611619474792 0.485726899896478 no 1609 0.463086376245259 2644 5319022 A signalling regulator. SGTC_1213 1315-0166 115 µM -0.0943239562734044 0.486379345592537 no 1610 0.462425910197823 2696 768401 SGTC_1164 k060-0068 93.7 µM -0.0945836430738159 0.48648124459465 no 1611 0.462322771259506 2574 5963676 SGTC_2479 5617353 43.85 µM -0.095335698709627 0.486776350105012 no 1612 0.462024094152886 2663 2731746 SGTC_3210 9128157 49.47 µM -0.0953594353871654 0.486785664460624 no 1613 0.462014667535591 2726 17590849 SGTC_189 3970-0742 2.116 µM -0.0961927829095858 0.487112677487016 no 1614 0.461683731319714 2584 2891807 SGTC_1600 coumarin 106 71.1 µM -0.0965838360596483 0.487266133243684 no 1615 0.461528446715139 2735 100336 A hepatotoxic, DNA x-linker. SGTC_518 1021-0119 62.6 µM -0.0972601611105158 0.487531538873546 no 1616 0.461259896392983 2633 1097762 SGTC_416 estradiol valerate 100 µM -0.0978809478693199 0.487775154853367 no 1617 0.46101341436458 2629 13791 A steroid. SGTC_34 0469-0683 81.75 µM -0.0981185256632442 0.487868388960794 no 1618 0.460919088577188 2649 3690923 SGTC_1656 st012921 11 µM -0.0983001964044404 0.487939683569024 no 1619 0.460846961115112 2650 6732821 SGTC_1187 1391-0724 117 µM -0.0983854510537747 0.487973140915804 no 1620 0.460813113502672 2614 6997986 SGTC_1841 st054148 70 µM -0.098463644378236 0.488003827189661 no 1621 0.460782069611428 2632 675442 SGTC_1644 st010134 20.9 µM -0.098482676102437 0.488011296031096 no 1622 0.460774513775263 2602 3818134 SGTC_439 amiodarone 34.4 µM -0.0989490769894152 0.488194332476993 no 1623 0.460589351133695 2664 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1530 rhein 70.4 µM -0.0989708445183006 0.488202875084223 no 1624 0.460580709563614 2561 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3102 9121669 49.47 µM -0.0992187592526971 0.488300168925192 no 1625 0.460482290310317 2610 41905072 SGTC_1526 st051518 75 µM -0.0995040446715781 0.488412129707851 no 1626 0.460369038327987 2659 673993 SGTC_2468 5987765 72.9 µM -0.099964820611916 0.488592963990304 no 1627 0.46018612729525 2661 26772094 SGTC_421 streptovitacin 30 mM -0.100820671097432 0.488928853843399 no 1628 0.459846408643802 2776 91467 include heat shock SGTC_3338 9144300 39.5675 µM -0.101261059592867 0.489101693213278 no 1629 0.459671613599511 2637 4901274 SGTC_2814 7977482 42.97 µM -0.101870820415252 0.489341009549519 no 1630 0.459429605688148 2680 6456762 SGTC_2593 nobiletin 86.24 µM -0.102774134760035 0.489695545552801 no 1631 0.459071117004792 2665 72344 An anti-infammatory. SGTC_254 nsc-64875 3.808 µM -0.103453151588952 0.489962053850831 no 1632 0.458801664767321 2745 56993 SGTC_1674 st016616 23.6 µM -0.103867251529383 0.49012458674341 no 1633 0.458637347997565 2568 625830 SGTC_68 0986-0284 82.829 µM -0.104297558160765 0.49029348244696 no 1634 0.458466607825992 2838 423278 YIL048W NEO1 SGTC_2828 7998861 71.43 µM -0.105509531053175 0.490769192050839 no 1635 0.457985753758632 2617 2988188 SGTC_2115 tiliquinol 12.7705 µM -0.105515285987083 0.490771450942896 no 1636 0.457983470616573 2693 71208 A bioactive hydroxyquinoline. SGTC_139 0099-0334 718.624 µM -0.105813865893943 0.490888648137105 no 1637 0.457865017581502 2590 97690 SGTC_230 MPP+ 141.667 µM -0.105964811555208 0.490947896924918 no 1638 0.457805135632786 2634 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1178 0988-0033 191 µM -0.106262371689773 0.491064695017911 no 1639 0.457687092775776 2719 5392207 SGTC_1729 st035615 45.989 µM -0.1069769206451 0.491345172376887 no 1640 0.457403644662853 2745 17385451 SGTC_1317 1273-0028 910 nM -0.107048747882773 0.491373366504879 no 1641 0.457375153346482 2613 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1245 0418-0076 17.2 µM -0.107438491291618 0.491526352052165 no 1642 0.457220559789462 2743 6790114 SGTC_1870 st057514 26.5 µM -0.108014132183781 0.491752310005588 no 1643 0.456992240968625 2583 5393161 SGTC_3304 9125678 46.087 µM -0.108185960828867 0.491819758907607 no 1644 0.456924090612327 2630 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2783 7738165 71.43 µM -0.108936228078154 0.492114268409545 no 1645 0.456626535885603 2663 17201110 SGTC_882 0843-0131 351 µM -0.109005277266544 0.492141373159223 no 1646 0.456599152313372 2583 5425421 SGTC_2956 9076196 2.52 µM -0.110358927520651 0.492672745755161 no 1647 0.456062362599253 2647 16423868 SGTC_2388 9080168 200 µM -0.110510336427223 0.492732181832857 no 1648 0.456002326398315 2593 15943073 SGTC_2022 5136654 200 µM -0.110753337193727 0.492827572941279 no 1649 0.45590597457097 2727 1713771 SGTC_1762 st045503 25.4615 µM -0.111136405283663 0.492977948975526 no 1650 0.455754090151645 2662 4645554 SGTC_2625 euphol 100 µM -0.111206995502806 0.493005659764927 no 1651 0.455726102217639 2676 6708538 A triterpene alcohol. SGTC_106 0092-0003 11.579 µM -0.111618004968152 0.493167005683615 no 1652 0.455563147666996 2725 1072148 SGTC_1102 cgs 12066b 26.1 µM -0.112927883844739 0.493681219202386 no 1653 0.455043864808997 2683 6438352 A 5-HT1B full agonist. SGTC_2624 nerol 100 µM -0.113060947619264 0.493733456078047 no 1654 0.454991117850173 2578 637566 A natural product oil. SGTC_76 0433-0009 400.328 µM -0.113274646789391 0.493817348233441 no 1655 0.454906408391445 2772 2841569 SGTC_2975 9084847 53.72 µM -0.114328248626073 0.494230965974835 no 1656 0.454488795072509 2715 27211724 SGTC_2792 7535235 81.82 µM -0.114472383034364 0.494287550032441 no 1657 0.454431668806849 2686 1281891 SGTC_3090 9117696 49.47 µM -0.115138989758536 0.494549246920982 no 1658 0.454167478017569 2720 7923821 SGTC_1294 1000-1494 117 µM -0.116069951566906 0.494914728396095 no 1659 0.4537985514986 2622 712797 YDL207W GLE1 SGTC_2789 5281112 71.43 µM -0.118351726240279 0.495810535923106 no 1660 0.452894486872258 2671 765948 SGTC_2437 5741531 144.16 µM -0.118366609063455 0.49581637888149 no 1661 0.452888590927641 2727 2262990 SGTC_1990 st072050 59.8 µM -0.118553097919355 0.495889594005894 no 1662 0.452814712817098 2588 17233948 SGTC_2098 5376439 882.5 nM -0.119883658836998 0.496411973236759 no 1663 0.452287654733459 2722 2844116 SGTC_1018 4259-0013 28.1 µM -0.120746230188452 0.496750622750158 no 1664 0.451946020229024 2770 6801262 SGTC_1581 himbacine 57.9 µM -0.120915729995099 0.496817169443384 no 1665 0.451878891427224 2604 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2264 7948757 110.76 µM -0.121575973136834 0.497076385892735 no 1666 0.451617421484691 2609 2971411 SGTC_2608 thymoquinone 42.66 µM -0.122817267809592 0.497563730821242 no 1667 0.451125900024454 2593 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2464 5717415 7.67 µM -0.122869481645112 0.497584230589529 no 1668 0.451105226296207 2632 5285744 SGTC_867 0518-0118 155 µM -0.123032687250842 0.497648307078104 no 1669 0.451040606954585 2648 6848158 SGTC_204 PMA1.184 62.41 µM -0.123738879025169 0.497925567161326 no 1670 0.450761013596163 2598 2252213 YGL008C PMA1 SGTC_3025 9087895 49.47 µM -0.124954264934951 0.498402745761202 no 1671 0.45027987888399 2675 17173641 SGTC_2248 tofa 1.1 µM -0.125197455708607 0.498498226375198 no 1672 0.450183615723994 2634 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_425 3825-7017 13.1 µM -0.125889781014226 0.498770044891748 no 1673 0.44990958594387 2883 3397440 SGTC_3033 9090887 49.47 µM -0.127354730376424 0.499345210287706 no 1674 0.449329822168466 2645 19325384 SGTC_715 0868-0130 184 µM -0.127711693106436 0.499485360510139 no 1675 0.449188568056605 2717 2876258 SGTC_1509 1326-1131 80 µM -0.127869998127952 0.499547514034123 no 1676 0.449125927063635 2619 768313 SGTC_2618 avocadyne 43.43 µM -0.128018721765746 0.499605905736978 no 1677 0.449067078560974 2665 3015189 SGTC_356 1634-0012 32.5 µM -0.128948611137528 0.499970997969624 no 1678 0.448699155799409 2642 735457 SGTC_2097 5376186 200 µM -0.129096347367916 0.499970997969624 no 1679 0.448640706101332 2673 742755 SGTC_2984 9022109 38.96 µM -0.129149775056118 0.499950021240684 no 1680 0.448619568485345 2602 6459207 SGTC_991 3996-0057 64.7 µM -0.12918550056335 0.499935994725543 no 1681 0.448605434471111 2713 715343 SGTC_886 0866-0150 153 µM -0.130966573817466 0.499236711873287 no 1682 0.447900874916416 2805 271463 SGTC_2333 9017922 200 µM -0.131116025219974 0.499178034519074 no 1683 0.447841762155139 2767 3163164 SGTC_1048 3161-0300 24.5 µM -0.131311191106713 0.499101408849165 no 1684 0.447764569612232 2626 2165101 SGTC_654 1124-0271 80.9 µM -0.13227562799216 0.498722753962065 no 1685 0.447383142006736 2670 5403748 SGTC_2167 5876490 200 µM -0.132763317841573 0.49853127876464 no 1686 0.447190282804413 2896 686534 SGTC_1780 st038448 24.544 µM -0.134720348191205 0.49776291974273 no 1687 0.446416492163954 2846 728868 YDL195W SEC31 SGTC_1123 mangostin 811.285 nM -0.134966712107408 0.497666194159501 no 1688 0.446319096679138 2733 5281650 An antioxidant. SGTC_1239 0337-0584 35.4 µM -0.136071938514245 0.497232270091064 no 1689 0.445882205494319 2784 914301 YML130C ERO1 SGTC_136 0097-0015 404.482 µM -0.136836912977906 0.496931934572253 no 1690 0.445579852862826 2612 4861337 SGTC_3321 9137793 26.8275 µM -0.137395216261533 0.496712741014789 no 1691 0.44535920603034 2651 4904192 SGTC_2830 7992007 71.43 µM -0.137728228190984 0.496581998799584 no 1692 0.44522760456389 2587 1952075 SGTC_1724 st037281 8.293 µM -0.137839341478087 0.496538375226252 no 1693 0.44518369555267 2649 574124 YDL195W SEC31 SGTC_1515 3460-0031 42.1 µM -0.138161401858326 0.496411933116686 no 1694 0.44505642967087 2681 2876596 SGTC_2060 5238662 140 µM -0.13854783656005 0.496260217884631 no 1695 0.444903733006684 2752 790130 SGTC_2418 pentamidine 31.67 µM -0.139089432072701 0.496047587044668 no 1696 0.444689739518738 2615 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1993 st073995 70.8 µM -0.140672422639489 0.495426110316236 no 1697 0.444064365983058 2687 3098394 SGTC_2606 farnesol 9.78 µM -0.140718202371936 0.495408137506413 no 1698 0.444046282384844 2776 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2560 caryophyllene 100 µM -0.14135691935162 0.495157382577646 no 1699 0.443793992919998 2643 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2055 5235184 200 µM -0.142811454154703 0.494586351711733 no 1700 0.443219545351883 2785 2836034 SGTC_1472 k841-0093 193 µM -0.1437784417983 0.49420673139136 no 1701 0.442837713465068 2767 X1472 SGTC_961 1252-1571 372 µM -0.144437335882228 0.493948065524215 no 1702 0.442577568064817 2770 6813498 SGTC_3241 9133421 49.47 µM -0.144569419027229 0.49389621318158 no 1703 0.442525421804763 2643 17018221 SGTC_1710 st031758 61.5 µM -0.145161084261115 0.493663942367532 no 1704 0.44229184534517 2816 5394341 SGTC_552 k242-0005 476 µM -0.147199264806442 0.492863828035228 no 1705 0.441487370438276 2767 4088318 SGTC_2114 5491910 81.25 µM -0.147947334624903 0.492570170511998 no 1706 0.441192165796021 2772 2849228 SGTC_3235 9132602 49.47 µM -0.148772597026934 0.492246215437432 no 1707 0.440866537186241 2755 4912240 SGTC_2049 5262831 67.185 µM -0.149610489764996 0.491917307583366 no 1708 0.440535965851573 2717 763417 SGTC_817 1391-0715 46 µM -0.150837724179932 0.491435576860356 no 1709 0.440051863556433 2734 1353946 SGTC_2349 9023730 187.07 µM -0.151583926750314 0.491142673352991 no 1710 0.439757555746364 2786 4126287 SGTC_3126 9127922 49.47 µM -0.152097619467007 0.490941038649054 no 1711 0.439554970877327 2934 45595682 SGTC_3229 9132204 49.47 µM -0.15240678973326 0.4908196842254 no 1712 0.439433051102552 2662 17682924 SGTC_73 0327-0325 16.231 µM -0.153274061451704 0.4904792703573 no 1713 0.439091077459579 2859 53298 SGTC_2647 atorvastatin 60.16 µM -0.155325368918998 0.48967413723671 no 1714 0.438282408406122 2765 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1197 1601-0112 267 µM -0.156778283886552 0.489103896957062 no 1715 0.437709794066936 2683 7350313 SGTC_3023 9089636 49.47 µM -0.157342948966245 0.488882283069708 no 1716 0.437487286699907 2656 17249241 SGTC_2987 9018338 71.43 µM -0.157601921475023 0.488780645372457 no 1717 0.437385244689779 2655 5055682 SGTC_3184 9108758 49.47 µM -0.158487686300592 0.488433019051657 no 1718 0.437036261471328 2652 902885 SGTC_3004 9076122 71.4286 µM -0.159112346461283 0.488187870857817 no 1719 0.436790180535978 2814 44782551 SGTC_1531 st059297 52.4 µM -0.160460141865818 0.487658943198816 no 1720 0.436259308463536 2807 7566702 SGTC_374 0880-0231 82.3 µM -0.161333530327466 0.487316202920962 no 1721 0.435915357888435 2764 6833587 SGTC_2463 5473429 200 µM -0.162064433115169 0.487029384905503 no 1722 0.435627557072271 2759 5399405 SGTC_18 0111-0177 500 nM -0.164731966981773 0.485982659724795 no 1723 0.434577477344544 2711 721752 SGTC_1611 st001856 99.4 µM -0.16590410986419 0.48552274760978 no 1724 0.434116206557902 2727 647478 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.166369911494012 0.485339986967892 no 1725 0.433932925545622 2839 5393153 SGTC_3134 9127454 49.47 µM -0.1665051923132 0.485286909134378 no 1726 0.433879698667492 2697 24262820 SGTC_2254 7938975 95.19 µM -0.166553579598369 0.485267924301747 no 1727 0.433860660752348 2891 2969277 SGTC_1703 st026983 48.3 µM -0.166923725946104 0.485122697868232 no 1728 0.43371503222678 2810 1104023 SGTC_1868 st057644 42.7 µM -0.16825420008757 0.484600704517282 no 1729 0.433191651576635 2689 688665 SGTC_2644 guaiazulene 100 µM -0.168470521349438 0.484515836296316 no 1730 0.433106566373112 2796 3515 A coloring agent. SGTC_260 nsc-65238 3.989 µM -0.169051979828934 0.484287719134375 no 1731 0.432877877867462 2821 3246252 SGTC_604 1000-0114 314 µM -0.170407684487913 0.483755870649838 no 1732 0.432344764591883 2832 1572745 SGTC_2236 dapsone 200 µM -0.170623392565558 0.483671250129036 no 1733 0.43225995151905 2727 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3040 9091894 49.47 µM -0.170666229392915 0.4836544456782 no 1734 0.43224310911384 2723 25236966 SGTC_688 0527-0193 473 µM -0.171631669053788 0.483275721295621 no 1735 0.431863554288997 2767 4007154 SGTC_522 1273-0010 11.6 µM -0.171969996948938 0.483143004981783 no 1736 0.431730558265629 2947 5705015 SGTC_3325 9138760 55.175 µM -0.172085867935854 0.483097552550972 no 1737 0.431685011388968 2744 43844959 SGTC_990 3985-0011 41.3 µM -0.172155083576185 0.483070401604493 no 1738 0.431657804353658 2790 5399565 YGL099W LSG1 SGTC_2253 7938677 135.83 µM -0.17279121336433 0.482820873171755 no 1739 0.431407771938799 2922 2301972 SGTC_2997 9067075 71.4286 µM -0.173037091048366 0.48272442692652 no 1740 0.431311136454578 2805 27209819 SGTC_2301 7769476 200 µM -0.17350361547878 0.482541434129015 no 1741 0.431127793120269 2797 977820 SGTC_3354 9151612 71.43 µM -0.173927435452726 0.482375195212773 no 1742 0.430961245430581 2834 27261949 SGTC_2390 9097792 176.6 µM -0.174173735634005 0.48227858796951 no 1743 0.430864462978053 2726 4497149 SGTC_2413 inermin 26.06 µM -0.176451595957501 0.481385184326838 no 1744 0.42996958638978 3022 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2973 9094665 17.96 µM -0.176769483681753 0.481260512348945 no 1745 0.429844730015195 2952 25237061 YIL048W NEO1 SGTC_702 1488-0190 94 µM -0.176778488063773 0.481256980958571 no 1746 0.429841193477148 2819 949357 SGTC_1775 st081588 35.1725 µM -0.177290571161887 0.481056151690158 no 1747 0.429640078301575 2733 1426443 YGL099W LSG1 SGTC_2867 9039098 71.43 µM -0.178675375036325 0.480513082128391 no 1748 0.429096302940835 2701 6463460 SGTC_2897 9048598 12.99 µM -0.17874208511541 0.480486921773971 no 1749 0.429070111069356 2741 6467404 SGTC_565 1418-0001 44.5 µM -0.179008713069338 0.480382364474517 no 1750 0.428965430081407 2875 2862145 SGTC_1455 4262-0120 131 µM -0.179371265134809 0.48024019300825 no 1751 0.428823096277846 2918 1529587 SGTC_165 k038-0023 64.381 µM -0.179980543314903 0.480001275830356 no 1752 0.42858392147393 2745 46368543 SGTC_2616 abietic acid 100 µM -0.180678147706079 0.479727731988473 no 1753 0.428310106040714 2783 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1169 aniline yellow 25.8 µM -0.182117029937926 0.47916354941922 no 1754 0.42774544213104 2772 6051 A DNA damaging agent. SGTC_1861 st057647 17.4 µM -0.182155799121247 0.479148348679891 no 1755 0.427730229891804 2911 688668 SGTC_934 2950-0684 338 µM -0.182447285020736 0.47903406297447 no 1756 0.427615860193417 2953 1121253 SGTC_608 k048-0125 159 µM -0.184107247223608 0.478383258623358 no 1757 0.426964660600579 2821 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_322 k048-0136 19.3 µM -0.184961621446866 0.478048315243736 no 1758 0.426629568890084 2820 6823282 SGTC_3101 9120531 49.47 µM -0.186076440745552 0.47761129200051 no 1759 0.426192408406 2972 24824904 SGTC_3053 9095903 49.47 µM -0.186233630208514 0.477549673899536 no 1760 0.426130776082477 2741 17174018 SGTC_1166 k206-0078 225 µM -0.187657303552615 0.476991620097966 no 1761 0.425572651192796 2731 5404595 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.188078361795697 0.476826581596487 no 1762 0.425407611589163 2731 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1514 1189-1591 158 µM -0.188266271499612 0.476752929561268 no 1763 0.425333961997093 2942 767698 YMR146C TIF34 SGTC_1739 st037196 92.5 µM -0.188334303950231 0.476726264138591 no 1764 0.425307297905562 2867 612214 SGTC_1824 st053723 68.6 µM -0.18860366418765 0.476620689007422 no 1765 0.425201730375748 2767 675225 SGTC_2486 5283202 22.39 µM -0.18879166085626 0.476547005113544 no 1766 0.425128053992461 2802 1377751 SGTC_1175 0741-0056 27.6 µM -0.191023974487462 0.475672128404361 no 1767 0.424253405041946 2923 765927 SGTC_345 1362-0200 395 µM -0.191041614074391 0.475665215650966 no 1768 0.42424649510622 2762 1419823 SGTC_3013 9080133 71.4286 µM -0.191346837166342 0.475545603356053 no 1769 0.42412693409379 2940 17050193 SGTC_1736 st036774 51 µM -0.191442661915739 0.475508051545906 no 1770 0.424089399369432 3024 1272247 SGTC_334 1502-1024 68.5 µM -0.193655487478147 0.474640950492865 no 1771 0.423222823893125 2848 3296216 SGTC_2919 7978188 46.38 µM -0.194163835189497 0.474441770028227 no 1772 0.423023799645901 2868 2980291 SGTC_862 0452-0056 10.2 µM -0.194970808555304 0.474125595396347 no 1773 0.42270790022233 2742 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3155 9099265 49.47 µM -0.19604247782636 0.473705737324826 no 1774 0.422288459263084 2862 25236499 SGTC_2175 5807670 165.306 µM -0.197722375117289 0.473047646923414 no 1775 0.421631141247724 2846 241186 SGTC_365 0121-0052 13.6 µM -0.198396596662791 0.472783544975154 no 1776 0.421367389996687 2893 3101739 SGTC_946 3434-1334 87.4 µM -0.199469768009253 0.472363193571129 no 1777 0.420947644891671 2897 4047976 SGTC_2215 7188065 200 µM -0.199693443213043 0.472275585899504 no 1778 0.420860171025827 2886 940217 SGTC_1307 1187-1599 12.2 µM -0.199764337729739 0.472247818668876 no 1779 0.420832446740831 2760 1538471 SGTC_1121 fusaric acid 630.51 nM -0.201648684870272 0.471509826938593 no 1780 0.420095690959756 2777 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2221 6807166 181.081 µM -0.201671412976155 0.471500926222572 no 1781 0.420086806262545 2825 674925 SGTC_218 alverine citrate 93.75 µM -0.202694979868246 0.471100094697696 no 1782 0.419686723608188 2878 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_884 0851-0618 334 µM -0.202964745754794 0.470994458514945 no 1783 0.419581293739166 2906 9642473 SGTC_1741 st038134 10.228 µM -0.2030852789993 0.470947260204676 no 1784 0.419534188817417 2960 1272587 SGTC_2334 9017922 200 µM -0.204302597000981 0.470470606792693 no 1785 0.419058520330311 2920 3163164 SGTC_766 1391-0721 126 µM -0.205139729550994 0.470142843421735 no 1786 0.418731478369679 2949 1020919 YIL115C NUP159 SGTC_1247 0448-0043 5.84 µM -0.206362723581891 0.469664039730091 no 1787 0.418253793198179 2898 3089013 YGL099W LSG1 SGTC_1933 st074711 15.9 µM -0.207296008441917 0.469298687011677 no 1788 0.417889345624911 2719 17250958 SGTC_2242 6630449 61.2675 µM -0.207645652007006 0.469161818799423 no 1789 0.4177528280119 2965 691249 YDR170C SEC7 SGTC_1080 nisoldipine 24.4 µM -0.208190489442308 0.468948549083004 no 1790 0.41754011711351 2738 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2856 9022925 19.48 µM -0.208329392668578 0.468894178596448 no 1791 0.417485891528714 2928 4944862 SGTC_917 harmaline 728.087 nM -0.209324151258793 0.468504820143622 no 1792 0.417097599696479 2893 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1622 st003707 19.4 µM -0.210119297835163 0.468193613472448 no 1793 0.41678728208964 2899 10140899 SGTC_445 e6 berbamine 66 µM -0.211319382881144 0.467723957724993 no 1794 0.416319029536339 2879 6610268 A calcium/calmodulin antagonist. SGTC_2142 5622915 118.518 µM -0.211808029643859 0.467532737643994 no 1795 0.416128401949382 2806 5322196 SGTC_1277 0873-0036 22 µM -0.212235374325155 0.467365512788107 no 1796 0.415961705287938 2859 5965735 SGTC_936 3005-4620 401 µM -0.212320026898969 0.467332387951398 no 1797 0.415928686191669 2984 777207 SGTC_2607 solasodine 47.35 µM -0.212999242714698 0.467066616728355 no 1798 0.415663776678258 2818 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1843 st055809 45.5 µM -0.21318905411646 0.46699234780254 no 1799 0.415589752789349 2916 16413835 SGTC_1942 st076330 65.2 µM -0.21421472815861 0.46659104460215 no 1800 0.415189805623355 2949 24208414 SGTC_2012 4023501 200 µM -0.214726911426833 0.466390661476548 no 1801 0.414990119830224 2869 3477460 SGTC_2214 7179297 48.276 µM -0.215058509307588 0.466260933899386 no 1802 0.414860850888176 2775 769744 SGTC_2772 vinpocetine 57.06 µM -0.216369292623317 0.465748165049629 no 1803 0.414349950138635 2972 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2805 7950783 58.44 µM -0.216566725427642 0.465670935686337 no 1804 0.414273009779814 2910 1178958 YDL195W SEC31 SGTC_2456 5770359 74.46 µM -0.216580703736979 0.465665467870263 no 1805 0.414267562501048 2940 3118787 SGTC_1430 4049-0248 69.1 µM -0.216648258056654 0.465639043121116 no 1806 0.414241237145603 2897 22774488 SGTC_1200 1643-0193 18.4 µM -0.216700390678318 0.465618650872918 no 1807 0.414220921760747 2780 5403974 SGTC_1176 0848-0131 83.3 µM -0.217507437324636 0.465302977252472 no 1808 0.413906455794477 2893 6769040 SGTC_3095 9117207 49.47 µM -0.218297725337737 0.464993879872209 no 1809 0.413598573322057 2924 17015229 SGTC_3 0833-0587 95.581 µM -0.218317347135853 0.464986205664153 no 1810 0.413590929685542 2834 5382644 SGTC_2398 5228213 48.84 µM -0.218825016216274 0.464787657644839 no 1811 0.413393179490163 2960 80771 YMR134W ERG29 SGTC_1618 st003135 44.5 µM -0.219178811758445 0.464649294335555 no 1812 0.413255379990944 2723 1270615 SGTC_1057 3448-5381 134 µM -0.219920598389571 0.464359208326942 no 1813 0.412966496907367 2928 5497911 SGTC_1076 itraconazole 331 nM -0.220341294146228 0.464194697792081 no 1814 0.412802681120256 2774 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1926 methyl fluorone black 53.6 µM -0.220798916299227 0.464015754364585 no 1815 0.412624503713164 2789 72721 Reacts with homocysteine. SGTC_986 1493-0483 84 µM -0.221034136616631 0.463923779283242 no 1816 0.412532926543185 2833 40079 SGTC_1163 k060-0048 49.9 µM -0.223788003687034 0.46284711588011 no 1817 0.411461132462069 2803 6809982 SGTC_3227 9130768 49.47 µM -0.224721780550591 0.462482103950411 no 1818 0.411097859755657 2807 17720899 SGTC_55 0767-0285 6.563 µM -0.225776874968337 0.462069707206686 no 1819 0.410687481901688 2931 3116166 SGTC_465 cgp-37157 41 µM -0.227515324168409 0.461390301912516 no 1820 0.410011527344571 2897 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.227942715749265 0.461223289704181 no 1821 0.409845387171107 2909 616764 SGTC_1826 st055655 41.6 µM -0.228697086295646 0.460928520325524 no 1822 0.409552179790051 2879 676168 SGTC_2328 6201408 200 µM -0.229595631223609 0.460577443007347 no 1823 0.409203000988515 2937 2890418 SGTC_2526 patulin 37.61 µM -0.230040889317962 0.460403484202056 no 1824 0.40902999826384 2954 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2714 st079313 56.9 µM -0.230805479168733 0.460104782711004 no 1825 0.408732962196857 2822 2939799 SGTC_3104 9120930 49.47 µM -0.231010355802744 0.460024747595369 no 1826 0.408653378421521 2901 17014836 SGTC_1181 1222-0449 220 µM -0.231050956474689 0.460008887123463 no 1827 0.408637607647186 3001 658318 SGTC_586 0957-0265 8.15 µM -0.23202480874473 0.459628475192044 no 1828 0.40825937247435 2860 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_495 decylubiquinone 155 µM -0.232836759175743 0.459311334551119 no 1829 0.40794408378322 2886 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.233010245548331 0.459243575662002 no 1830 0.407876724964109 2965 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_220 paclitaxel 373.376 µM -0.234113332496074 0.458812768758251 no 1831 0.407448497844221 2927 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1486 3970-0793 4.53 µM -0.234821878902221 0.458536073818749 no 1832 0.407173492790655 2927 2844330 SGTC_3346 9158254 43.5805 µM -0.235193144720438 0.458391098563814 no 1833 0.407029413252805 2914 17639500 SGTC_2355 9061122 103.12 µM -0.235258591723432 0.458365542795852 no 1834 0.407004016112974 2958 5302957 SGTC_972 1319-0219 195 µM -0.23554385707895 0.45825415429414 no 1835 0.406893321584215 2907 23903702 SGTC_1046 2001-0062 216 µM -0.235707323962803 0.458190326319255 no 1836 0.406829893154391 2799 739778 SGTC_237 nikkomycin 200 µM -0.236235436953448 0.457984124450422 no 1837 0.406624991430638 2979 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3254 9136651 49.47 µM -0.237122442299893 0.457637818431897 no 1838 0.406280901177935 2834 16454030 SGTC_1258 0671-0043 57.1 µM -0.238715814966534 0.45701581232344 no 1839 0.405662976336783 2890 4298767 SGTC_2194 5927483 104.545 µM -0.241639396798912 0.455874806363423 no 1840 0.404529796144357 2822 760979 SGTC_1648 st011736 69.8 µM -0.242245056009645 0.455638476847662 no 1841 0.404295142422997 2987 2855514 SGTC_1192 1488-0095 21.4 µM -0.242691839222112 0.45546415114058 no 1842 0.404122064921693 2901 915875 SGTC_1805 st050013 60.3 µM -0.242818393326466 0.455414773864324 no 1843 0.404073043059684 2888 4037144 SGTC_2316 5844804 197.44 µM -0.243077603356013 0.45531364073154 no 1844 0.403972640444238 2963 776813 SGTC_798 1287-0182 476 µM -0.243361131742765 0.455203022888534 no 1845 0.403862825581584 3006 1649755 SGTC_1747 st037496 66.6 µM -0.243740902172983 0.455054861912506 no 1846 0.40371574658247 2857 723305 SGTC_1342 1486-1464 234 µM -0.244900201906564 0.454602619590579 no 1847 0.403266852675733 2831 3253938 SGTC_46 0329-0187a 2.197 µM -0.24532304005037 0.454437685227891 no 1848 0.403103156671747 2934 46494817 SGTC_1590 st077108 57.8 µM -0.246075590973348 0.454144160898511 no 1849 0.402811858894386 2936 5489485 SGTC_818 4072-2707 53.5 µM -0.249135791871299 0.452950822345852 no 1850 0.401627872105885 2808 882871 SGTC_2727 riluzole 51.77 µM -0.249501736870839 0.452808148737915 no 1851 0.401486348775002 2836 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2687 chenodiol 100 µM -0.250008137138137 0.452610724877387 no 1852 0.401290527948397 2946 5702181 A cholesterol synthesis inhibitor. SGTC_2536 dehydroabietamide 32.04 µM -0.25066059473115 0.452356376773785 no 1853 0.401038264505867 3001 3983547 SGTC_3301 9125354 19.7965 µM -0.250674260098315 0.452351049800636 no 1854 0.401032981426848 2819 41905162 SGTC_1276 0871-0068 94.2 µM -0.250784144163644 0.452308215590855 no 1855 0.400990500518555 2941 3414906 SGTC_3163 9099914 49.47 µM -0.251524152303292 0.452019765463153 no 1856 0.400704445710793 2943 16268368 SGTC_1124 fisetin 1.16336 µM -0.252051391306478 0.45181426673509 no 1857 0.400500670622525 2906 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3290 9121031 71.43 µM -0.25247494923413 0.451649188496045 no 1858 0.400336987333847 2894 17014854 SGTC_1306 1185-0270 9.02 µM -0.253453231775034 0.451267942875599 no 1859 0.399958998543932 2967 1548076 SGTC_3323 9138564 53.9225 µM -0.253611777368158 0.45120616043649 no 1860 0.39989774851596 3012 43912313 YNL103W MET4 SGTC_2933 9026794 32.47 µM -0.25368318548374 0.451178334331267 no 1861 0.39987016262429 2911 17586027 SGTC_563 tetrahydrosecaminediol 614 µM -0.253849425895811 0.451113555184267 no 1862 0.399805943708685 3009 334274 A psychoactive constituent of the cannabis plant. SGTC_1067 clotrimazole 1.36 µM -0.254751142801078 0.450762204553326 no 1863 0.399457656400863 2861 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_828 2074-0507 139 µM -0.254859367700601 0.450720037712237 no 1864 0.399415860006682 2985 X828 SGTC_1454 4239-0054 42.6 µM -0.255049542890969 0.450645942552861 no 1865 0.399342417250146 3043 1340767 SGTC_1305 1181-0477 144 µM -0.255377139193063 0.450518310063826 no 1866 0.399215912911909 2993 6252086 SGTC_337 1315-0038 354 µM -0.255584090109975 0.450437684010409 no 1867 0.399136002357308 2879 1626437 SGTC_2280 7785178 200 µM -0.256935655889968 0.449911177646431 no 1868 0.398614222447216 2873 2954328 SGTC_1356 1502-0781 85.8 µM -0.258313744050185 0.449374430184457 no 1869 0.398082389954544 2859 567702 SGTC_284 0988-0104 32.6 µM -0.259742847211484 0.448817910879662 no 1870 0.397531069666651 2949 4666532 SGTC_911 3456-4043 236 µM -0.259929052209049 0.448745406587407 no 1871 0.397459250433647 2961 914281 SGTC_1855 st056195 39.6 µM -0.25993135184979 0.44874451116658 no 1872 0.397458363484365 3048 4028379 SGTC_835 0312-0010 67.2 µM -0.25999313008616 0.448720456411536 no 1873 0.397434536412122 2845 1626196 SGTC_1151 3909-8316 15.3 µM -0.260336230782985 0.448586865820194 no 1874 0.397302213847562 2976 800431 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.260651311089788 0.448464190456072 no 1875 0.397180708228498 3066 688751 SGTC_1626 st003712 1.76 µM -0.260657464217914 0.448461794807177 no 1876 0.397178335473556 3031 24207035 SGTC_3207 9114163 49.47 µM -0.260831868419014 0.448393893341122 no 1877 0.397111083714496 3147 849233 SGTC_637 1181-0519 7.26 µM -0.260927265337657 0.448356752727202 no 1878 0.39707429913688 2875 6252091 YGR060W ERG25 SGTC_1358 1509-0022 2.48 µM -0.261598583571055 0.448095403107092 no 1879 0.396815468073651 2931 3258434 SGTC_2045 5106652 78.05 µM -0.262256637126761 0.447839239397157 no 1880 0.396561795404164 3008 673349 SGTC_442 cape 100 µM -0.2625673163296 0.447718307344509 no 1881 0.396442047070871 3001 5281787 SGTC_883 0850-0245 24.6 µM -0.26330340405262 0.447431804205152 no 1882 0.396158368091508 3071 6823229 YPR165W RHO1 SGTC_270 tamoxifen 5.46 µM -0.263440211661915 0.447378558393827 no 1883 0.396105650208256 3069 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1204 4049-0315 18.3 µM -0.264547632873106 0.446947582703926 no 1884 0.395678982981048 3119 588402 SGTC_723 4182-0001 115 µM -0.267335819562563 0.445862781170329 no 1885 0.394605305002517 2880 744821 YLR208W SEC13 SGTC_597 k018-0003 82.8 µM -0.26736331631064 0.445852084997532 no 1886 0.394594720495635 2990 6786234 SGTC_2940 9060638 45.86 µM -0.268595436596937 0.445372833555231 no 1887 0.394120512180154 2988 4027022 SGTC_509 pifithrin 175 µM -0.269180745074177 0.445145197072522 no 1888 0.393895298403265 2955 4817 A p53 inhibitor. SGTC_854 0422-0053 192 µM -0.2694632218542 0.445035343485028 no 1889 0.393786620265333 2898 3596728 SGTC_523 1934-0222 13.7 µM -0.270820062916205 0.444507734813777 no 1890 0.393264714173681 2879 1361595 SGTC_1838 st055369 84.5 µM -0.271119224996416 0.444391418608112 no 1891 0.393149667869753 2865 676036 SGTC_958 1222-0007 33 µM -0.271529988290876 0.444231718912405 no 1892 0.39299171920685 3060 7312461 SGTC_484 loperamide 105 µM -0.271708503983288 0.444162317036931 no 1893 0.392923080990576 2847 3955 An opioid-receptor agonist. SGTC_349 k015-0014 24 µM -0.273002661519182 0.443659236350544 no 1894 0.392425584833818 2836 2196908 SGTC_2427 5545055 42.75 µM -0.2734133195957 0.443499619275469 no 1895 0.392267757581541 2912 5372858 SGTC_521 r062-0005 13.8 µM -0.273453452560002 0.443484020642462 no 1896 0.392252334323887 2859 2832033 SGTC_3059 1327-0034 3 µM -0.2735198297908 0.443458221742049 no 1897 0.392226825661825 2896 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2524 avocatin b 10.57 µM -0.274347187022906 0.443136672177974 no 1898 0.391908912515697 2993 6710748 SGTC_2889 9059656 51.95 µM -0.274379738844155 0.443124021787972 no 1899 0.391896405907864 2978 3949838 SGTC_1220 1838-0075 193 µM -0.275535678465744 0.442674834615089 no 1900 0.391452359374433 2911 5529645 SGTC_733 4069-0007 56.1 µM -0.275667098518874 0.442623770682624 no 1901 0.391401884175309 2911 5717425 YNL287W SEC21 SGTC_1043 0916-0009 19.3 µM -0.275750030826058 0.442591547401818 no 1902 0.39137003286379 3093 3101130 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.280267168854749 0.440836996421853 no 1903 0.389636268624988 3097 551469 SGTC_2129 girgensonine 121.053 µM -0.280380550723968 0.440792971319941 no 1904 0.389592778572731 2975 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_54 0159-0055 9 µM -0.280594694419751 0.440709823355325 no 1905 0.389510642928615 3135 3319099 SGTC_1997 st073024 93.8 µM -0.281203221420796 0.440473558059673 no 1906 0.389277266989744 3028 686268 SGTC_852 0418-0143 439 µM -0.281775758196598 0.440251285592429 no 1907 0.389057730104973 3010 5369229 SGTC_869 0564-0080 44.1 µM -0.281862121214401 0.440217759036213 no 1908 0.38902461763133 2949 6843321 SGTC_3063 1327-0034 4 µM -0.281977207532374 0.440173082617156 no 1909 0.38898049360029 2990 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_607 4491-0986 66.8 µM -0.282542997786914 0.43995345436858 no 1910 0.388763590761394 3047 698981 YDR232W HEM1 SGTC_3058 9093861 49.47 µM -0.282554333003827 0.4399490544569 no 1911 0.388759245616901 3084 17217477 SGTC_2917 7979103 53.79 µM -0.282739874017117 0.439877035357195 no 1912 0.388688123900384 3055 2980565 SGTC_555 4296-0685 37 µM -0.283766460118291 0.439478594481911 no 1913 0.388294679658704 2940 2908540 YHR072W ERG7 SGTC_824 1304-0008 100 µM -0.28571619824264 0.438722026894003 no 1914 0.387547748625155 2927 768245 SGTC_949 1165-0505 146 µM -0.285730870147814 0.438716334519219 no 1915 0.387542129494578 2915 6244267 SGTC_397 arbidol 50 µM -0.286311220179077 0.438491181719177 no 1916 0.387319882609599 3061 131410 A RNA synthesis inhibitor. SGTC_726 3448-4391 34.2 µM -0.288506404633568 0.437639717838624 no 1917 0.386479564328797 3099 1356692 SGTC_307 1501-1223 22.3 µM -0.288541928803528 0.437625941155707 no 1918 0.386465970013967 3008 2830329 SGTC_2803 7707263 71.43 µM -0.288697564330933 0.437565584794301 no 1919 0.386406413379614 2930 2199229 SGTC_1017 4239-0030 168 µM -0.289027969816037 0.437437456445704 no 1920 0.386279986861307 2924 1149593 SGTC_324 1315-0088 19.6 µM -0.290770011929616 0.436762016589131 no 1921 0.385613610931102 2991 6787421 SGTC_1388 3346-4487 254 µM -0.291211181622306 0.436590991576014 no 1922 0.385444905651008 2998 3345614 SGTC_1226 3909-7979 35.4 µM -0.29131648760863 0.436550170129059 no 1923 0.38540463936983 3029 6615510 SGTC_406 estrone 100 µM -0.291411139054421 0.436513479448995 no 1924 0.385368448163029 3090 5870 A steroid. SGTC_1471 k673-0312 37 µM -0.291537455277092 0.436464515087877 no 1925 0.385320151073538 2948 24099884 SGTC_2596 sinensetin 100 µM -0.291669890015559 0.436413180032347 no 1926 0.385269516475446 2963 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3118 9124250 49.47 µM -0.292993266800699 0.43590026466735 no 1927 0.384763649144155 2969 1504786 SGTC_939 1165-0479 45.3 µM -0.293608327303555 0.435661915695589 no 1928 0.384528605923431 3052 1377347 SGTC_2112 5488546 200 µM -0.294365254821046 0.435368622334699 no 1929 0.384239406982707 2905 600757 SGTC_420 mitomycin C 81.9 mM -0.295038900841308 0.4351076286809 no 1930 0.383982081546479 2927 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3088 9117578 49.47 µM -0.297004138490463 0.43434638991386 no 1931 0.383231674785145 2982 678341 SGTC_1882 5615643 20 µM -0.29795367611259 0.433978671628206 no 1932 0.382869259868165 2959 2253075 SGTC_3024 9090631 49.47 µM -0.298549824652998 0.433747836098266 no 1933 0.382641777151481 3059 25236383 SGTC_149 3970-0822 46.1 µM -0.299127314732479 0.43352424688152 no 1934 0.382421452868935 2950 3114250 YBL034C STU1 SGTC_1572 epiandrosterone 68.9 µM -0.299140376910746 0.433519189789822 no 1935 0.382416469820511 2898 441302 A steroid. SGTC_931 2812-0076 566 µM -0.301474178087534 0.432615821734115 no 1936 0.38152646876075 2904 3450959 SGTC_2915 7971052 15.16 µM -0.30172451084538 0.432518943724491 no 1937 0.381431040817062 2989 5741558 SGTC_1957 st077035 62.4 µM -0.302720972504845 0.43213335638514 no 1938 0.381051256767664 3046 705593 SGTC_2141 5621638 7.665 µM -0.302850171180718 0.432083366840533 no 1939 0.381002023318304 3060 2856238 SGTC_3129 9127257 49.47 µM -0.303884858355521 0.431683065025123 no 1940 0.380607806950578 2957 837894 SGTC_2820 7989630 71.43 µM -0.304409450547162 0.431480136534149 no 1941 0.380407984366445 3007 2984098 SGTC_114 0364-0001 490.298 µM -0.305508099162737 0.431055203910064 no 1942 0.379989601205251 3009 4003655 SGTC_3264 9137442 49.47 µM -0.305554733782683 0.431037168447837 no 1943 0.379971845090918 3179 17015726 SGTC_246 cycloheximide 667 µM -0.305742445398315 0.430964574355411 no 1944 0.379900376521749 2932 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_928 2764-0428 58.7 µM -0.306828286009776 0.430544690864987 no 1945 0.379487038471083 3051 662578 SGTC_2100 5377183 190 µM -0.308813465085642 0.429777245669182 no 1946 0.378731712900186 3022 2844202 SGTC_92 0063-0024 660.874 µM -0.30907416728498 0.429676481130046 no 1947 0.378632554648018 2909 3594437 SGTC_2516 gossypol 71.55 µM -0.309087201954821 0.429671443193397 no 1948 0.378627597112477 3091 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_5 0352-0601 109.883 µM -0.309261691241657 0.429604003695136 no 1949 0.378561234728294 3012 762456 SGTC_666 0272-0154 136 µM -0.309331963005745 0.42957684448455 no 1950 0.378534509733228 2990 6870312 SGTC_51 1013-0126 23.419 µM -0.313355110631591 0.428022504933954 no 1951 0.377005442272849 3237 1627850 SGTC_3272 9137413 49.47 µM -0.313894293199371 0.427814276514701 no 1952 0.376800662431309 2924 17614870 SGTC_244 nsc-207895 1.295 µM -0.31400313776583 0.427772243964893 no 1953 0.376759327810002 2898 42640 SGTC_3057 9095946 49.47 µM -0.314149762224555 0.427715623234849 no 1954 0.376703648196578 2916 24540043 SGTC_741 4582-0002 126 µM -0.316372692590513 0.426857395986448 no 1955 0.375859820730407 2949 2912688 SGTC_1695 st026914 34.495 µM -0.3168449597699 0.426675107879742 no 1956 0.375680623728946 2939 3289191 SGTC_2211 7117706 200 µM -0.316902998624408 0.42665270682494 no 1957 0.375658603322285 3052 822771 SGTC_2764 methyldopa 94.69 µM -0.319852537448727 0.425514596651838 no 1958 0.37454005940363 3154 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1772 st048439 82.2 µM -0.320202420435975 0.425379631642921 no 1959 0.374407444237664 3058 2927068 YDL195W SEC31 SGTC_2705 st078069 42.8 µM -0.320488701957615 0.425269206974887 no 1960 0.374298946806964 3038 1530061 SGTC_1637 st007924 17.4 µM -0.321017767940513 0.425065150783084 no 1961 0.374098463037549 2947 683336 SGTC_182 3448-4371 550.524 µM -0.321915709080288 0.424718868598404 no 1962 0.373758276017642 2980 3491403 SGTC_2416 tofa 880 nM -0.322525265062943 0.424483832402151 no 1963 0.37352740037394 2973 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1832 st054113 55 µM -0.322531831375923 0.424481300670433 no 1964 0.373524913561815 3090 1251267 SGTC_2163 5671233 125 µM -0.323158002112438 0.424239886314654 no 1965 0.37328779266885 3195 701023 SGTC_3030 9087619 49.47 µM -0.323992484914434 0.42391820335545 no 1966 0.372971861899311 3016 25236973 SGTC_2907 7721985 69.9 µM -0.324869206415173 0.423580292496967 no 1967 0.37264003178494 3046 3267881 SGTC_2529 gangaleoidin 93.61 µM -0.328387722951028 0.422224734073759 no 1968 0.371309262225357 2957 4565183 SGTC_695 3505-6186 243 µM -0.330309710961983 0.421484648736533 no 1969 0.370582978029478 3106 1819379 SGTC_475 α-linolenic acid 10 µM -0.330537696984056 0.421396878234651 no 1970 0.370496856806507 3212 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_321 4534-3890 65.3 µM -0.330973173804979 0.421229238379911 no 1971 0.370332374426581 3093 699746 SGTC_2198 6589944 200 µM -0.331055938478292 0.421197379152631 no 1972 0.370301116360174 3030 5290268 SGTC_899 1083-0020 478 µM -0.331241384011783 0.421125996084235 no 1973 0.370231081510788 3162 767123 SGTC_2686 alizarin 95.37 µM -0.331508861152978 0.421023041368997 no 1974 0.37013007440816 3031 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3349 9149703 23.001 µM -0.331663250576661 0.420963617742488 no 1975 0.370071776573842 2952 4910494 SGTC_2134 5324836 1.464 µM -0.331940833694485 0.420856782081358 no 1976 0.36996696800017 2995 699272 SGTC_538 2922-0838 53.3 µM -0.333409712674012 0.42029153994469 no 1977 0.369412516266604 3179 777039 SGTC_926 2268-1401 59.4 µM -0.333448535943006 0.420276602512267 no 1978 0.369397865483921 2978 2931578 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.334168066165664 0.419999780735315 no 1979 0.369126369869193 3231 6710655 SGTC_1621 st003705 32.4 µM -0.334200488123525 0.419987308105267 no 1980 0.369114137840599 3150 24207032 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.335158483109637 0.419618806624603 no 1981 0.368752769129297 3017 4330530 SGTC_1971 st069429 63.5 µM -0.335844611526423 0.419354924386396 no 1982 0.368494023458829 3130 1246522 YGL099W LSG1 SGTC_2469 5655019 90.81 µM -0.335870242753884 0.419345067421057 no 1983 0.368484358829192 3133 2788239 SGTC_1432 4049-0298 68.4 µM -0.337636289075804 0.418666023674505 no 1984 0.367818645872819 3099 741646 SGTC_2090 5301565 104.445 µM -0.339744798907919 0.417855620367228 no 1985 0.367024360826862 3006 2056344 SGTC_2485 5633444 17.78 µM -0.339926536162049 0.417785786138437 no 1986 0.366955926174454 3083 5724239 SGTC_2352 9027995 87.8 µM -0.340010024386325 0.417753705881299 no 1987 0.366924489416428 3050 2997347 SGTC_2746 daunorubicin 9.88 µM -0.34137281914031 0.417230131047805 no 1988 0.366411467322514 3044 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1920 st075728 45.7 µM -0.342290814873087 0.416877527092026 no 1989 0.36606602362087 3183 3400306 SGTC_1857 st056007 79.3 µM -0.343601211075284 0.416374317245965 no 1990 0.365573106900957 3090 619834 SGTC_1853 st056710 91.2 µM -0.343704119983566 0.41633480462745 no 1991 0.365534406223684 3161 269167 SGTC_2041 5107442 45.335 µM -0.344957660538663 0.415853566669087 no 1992 0.365063100584677 3175 793005 SGTC_1983 st071813 46.9 µM -0.345183860425844 0.415766741272952 no 1993 0.364978075730572 3076 11838595 SGTC_3293 9120939 62.045 µM -0.345276088560403 0.41573134126657 no 1994 0.364943410581599 3169 934087 SGTC_257 daunorubicin 18.5 µM -0.345555786648864 0.415623988684839 no 1995 0.364838289152992 3106 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3136 9095672 49.47 µM -0.345928717611654 0.415480861637559 no 1996 0.364698142986353 2973 17217380 SGTC_247 mechlorethamine 29.705 µM -0.346360697115074 0.415315086389072 no 1997 0.364535829182549 3007 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2894 9048625 32.47 µM -0.347130366953066 0.41501975741373 no 1998 0.364246690381242 3193 4092861 SGTC_287 k060-0039 29.6 µM -0.347489030399898 0.414882151536927 no 1999 0.364111979087514 3153 5861974 SGTC_957 1187-1561 14.1 µM -0.347591258140875 0.414842932451727 no 2000 0.364073586190475 3084 1538454 SGTC_2756 carbadox 75.1 µM -0.3480890251812 0.414651979122645 no 2001 0.36388666309975 3033 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3316 9136639 10.545 µM -0.348417820515864 0.414525857755038 no 2002 0.36376321056926 3119 4903665 SGTC_2018 5133068 143 µM -0.348735967083498 0.414403829495893 no 2003 0.363643769785072 2967 785362 SGTC_1660 st012960 28.1 µM -0.350208984894478 0.413838946815708 no 2004 0.363090932128566 3110 24207266 SGTC_2099 5377090 177.372 µM -0.351267382989571 0.413433175238685 no 2005 0.362693881181726 3111 2243829 SGTC_1127 asiatic acid 681.4 nM -0.351997518407115 0.413153307763489 no 2006 0.362420061778282 3013 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_693 4161-2696 114 µM -0.353511417855926 0.412573157241286 no 2007 0.361852535222085 3124 805759 SGTC_2144 5628481 200 µM -0.354996052017459 0.412004407071793 no 2008 0.361296274450945 3036 2818399 SGTC_2742 clothiapine 36.27 µM -0.356052148687884 0.411599938215737 no 2009 0.360900755881759 3088 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3123 9126162 49.47 µM -0.356179778078343 0.411551064465691 no 2010 0.360852967485514 3006 25239884 SGTC_1229 0139-0193 12.2 µM -0.357243479313761 0.411143789572438 no 2011 0.360454769365934 3188 3090752 SGTC_2275 7947463 200 µM -0.357771289580373 0.410941734630772 no 2012 0.360257238951959 3174 1225414 SGTC_2871 9038510 12.99 µM -0.358957971347511 0.410487538583802 no 2013 0.359813265365066 3238 4945164 SGTC_1325 1431-0015 227 µM -0.359003394061142 0.41047015566627 no 2014 0.359796275106035 3035 1103340 SGTC_857 0438-0306 1.35 µM -0.36061195306282 0.409854686347251 no 2015 0.359194776258667 3129 4686136 SGTC_3232 9132874 49.47 µM -0.361529165258471 0.409503840508015 no 2016 0.358851953248217 3054 3784940 SGTC_2288 7946289 167.31 µM -0.363677869004398 0.408682216984053 no 2017 0.358049285652811 3234 1246052 SGTC_1097 itavastatin 7.23 µM -0.364085156563057 0.408526523071699 no 2018 0.357897210313499 3082 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2768 sulfasalazine 50.2 µM -0.364686373690324 0.408296722047401 no 2019 0.357672765668468 3190 5384001 An antioxidant and salicylic acid derivative. SGTC_1783 st039459 87.517 µM -0.365588033201881 0.407952143160314 no 2020 0.357336252993338 3240 729761 SGTC_2063 5246145 200 µM -0.366715982777196 0.407521185338368 no 2021 0.356915441698362 3163 711240 SGTC_1967 st070177 51.4 µM -0.367417937139796 0.407253044764369 no 2022 0.356653646957771 3211 5729214 SGTC_1477 0139-0234 16 µM -0.368181327198815 0.406961485611014 no 2023 0.356369016334964 3094 620880 SGTC_99 0109-0120 622.8 µM -0.36904803759586 0.406630528145704 no 2024 0.356045959605794 3279 759414 SGTC_1298 1079-1278 263 µM -0.369313311402254 0.406529245404487 no 2025 0.355947102364403 3088 2840950 SGTC_1928 4'-methoxychalcone 40.3 µM -0.370953051297063 0.405903324314029 no 2026 0.355336250188668 3259 641818 SGTC_2832 7992762 51.95 µM -0.371693945888887 0.405620588995771 no 2027 0.355060366532644 2989 2985177 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.372772130605876 0.405209227229331 no 2028 0.354659023383041 3125 6708739 YPR165W RHO1 SGTC_1312 1218-2183 165 µM -0.373616159261331 0.404887276485315 no 2029 0.354344954934128 3116 6744073 SGTC_325 2810-4341 181 µM -0.375034535012295 0.404346388834767 no 2030 0.353817391390196 3169 774970 SGTC_1498 4478-3555 97.6 µM -0.375950679548483 0.403997120627646 no 2031 0.353476781355192 3134 3437919 SGTC_1689 st020265 53.493 µM -0.377110818061935 0.403554942720513 no 2032 0.353045626033048 3202 5758320 YPR016C TIF6 SGTC_3148 9097893 49.47 µM -0.377184757926673 0.403526765279547 no 2033 0.353018153317129 3044 17174100 SGTC_2208 7283366 200 µM -0.378931354372219 0.40286130790967 no 2034 0.35236942001485 3156 898663 SGTC_350 k064-0020 19.8 µM -0.379034117569889 0.402822163631972 no 2035 0.352331264328503 3242 2790705 SGTC_709 3807-1509 243 µM -0.379338600069 0.402706186706872 no 2036 0.352218219559351 3125 1886677 YPL242C IQG1 SGTC_1383 3049-0032 20.7 µM -0.380512819018004 0.402259008734364 no 2037 0.351782391360417 3205 712864 SGTC_2309 7664088 163.95 µM -0.381121355056723 0.402027310141931 no 2038 0.351556601044506 3253 704922 SGTC_2806 7952793 58.44 µM -0.382111484166693 0.401650394538623 no 2039 0.351189336934593 3211 2972490 SGTC_1717 st033143 58.0435 µM -0.382177103946525 0.40162541807617 no 2040 0.351165001791869 3243 674616 SGTC_738 1315-0003 72.4 µM -0.382304444463096 0.401576950367276 no 2041 0.351117779210704 3214 6251474 SGTC_2000 st075254 36.4 µM -0.383535341566433 0.401108530640283 no 2042 0.350661435569189 3096 17234175 SGTC_719 2810-4230 27.3 µM -0.38386087626628 0.400984671660416 no 2043 0.350540782599681 3111 721079 SGTC_1534 6-azauridine 81.6 µM -0.383916765528152 0.400963407994108 no 2044 0.350520069871077 3076 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2533 agelasine 13.65 µM -0.384165661886448 0.400868716281066 no 2045 0.350427833529262 3284 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2304 7443016 91.4 µM -0.385290422801107 0.400440877791802 no 2046 0.350011128186332 3047 939854 SGTC_1579 chlormadinone acetate 49.4 µM -0.387634949546768 0.39954944717066 no 2047 0.349143100670555 3206 45114258 A steroidal progestin. SGTC_2699 st077704 54.6 µM -0.388199102428325 0.39933502419479 no 2048 0.348934348674137 3136 645852 SGTC_1634 st006576 41 µM -0.389117973410812 0.398985845152104 no 2049 0.348594439165589 3261 3915356 SGTC_1737 st035557 69.7 µM -0.391185418196675 0.398200493870934 no 2050 0.347830092938195 3117 5716916 SGTC_2517 totarol 10 µM -0.392863656136931 0.397563291850613 no 2051 0.347210092970772 3187 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1552 6-methylflavone 10.6 µM -0.393480658920809 0.397329093659591 no 2052 0.346982253155713 3198 689013 SGTC_2052 5265182 7.135 µM -0.394510318267817 0.396938344237728 no 2053 0.346602155388251 3233 1239884 SGTC_1381 2324-0066 62.1 µM -0.394516982727347 0.396935815452647 no 2054 0.346599695711803 3201 10885928 SGTC_657 3534-0529 86.7 µM -0.395448285741074 0.39658248134701 no 2055 0.346256039940628 3234 1049549 SGTC_390 dec-rvkr-cmk 16.7 µM -0.395499869925887 0.396562912911404 no 2056 0.346237008797996 3149 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2002 4023503 131 µM -0.396431472370644 0.396209554858701 no 2057 0.345893376153726 3278 4736863 YCR052W RSC6 SGTC_2110 5483698 200 µM -0.396770543987976 0.396080965686929 no 2058 0.345768337036201 3123 2848765 YHR062C RPP1 SGTC_203 k066-0004 30.888 µM -0.396839413665016 0.396054849002398 no 2059 0.3457429420858 3185 6795412 SGTC_1513 0337-0559 19 µM -0.397063383308801 0.395969918702388 no 2060 0.345660360495124 3108 775073 SGTC_3193 9111931 49.47 µM -0.397400537588934 0.395842077590515 no 2061 0.345536059565453 3080 17087244 SGTC_2436 5633522 8.09 µM -0.39875030443128 0.3953303895323 no 2062 0.345038598879806 3272 5724242 SGTC_784 4579-0127 173 µM -0.400354236167982 0.394722583794057 no 2063 0.344447813031032 3302 1948547 SGTC_138 0850-0259 40.9225 µM -0.400597534913275 0.394630408709778 no 2064 0.344358230432347 3198 6813004 SGTC_1492 4158-0558 28.5 µM -0.403186086642583 0.39365008768301 no 2065 0.343405667153447 3191 3967268 SGTC_598 3937-0236 20.2 µM -0.403884910699933 0.393385548389589 no 2066 0.343148676425879 3176 1379313 SGTC_2271 7849410 118.62 µM -0.404568549361491 0.393126805132779 no 2067 0.342897340264529 3257 972430 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.408440569485919 0.391662218653821 no 2068 0.341475126945172 3202 279621 SGTC_3077 9117319 49.47 µM -0.409307274820155 0.391334597915651 no 2069 0.341157088729893 3157 17154678 SGTC_1709 st033179 39.1045 µM -0.409324386835334 0.391328130228219 no 2070 0.341150810597159 3117 573381 SGTC_653 0203-0016 55.2 µM -0.409616015255713 0.391217910457035 no 2071 0.341043823418675 3167 295302 SGTC_3068 9116768 49.47 µM -0.409883760123274 0.391116725068358 no 2072 0.340945609443419 3225 41904888 SGTC_699 0375-0592 111 µM -0.41148246883839 0.390512699156719 no 2073 0.3403593967995 3266 762578 SGTC_3111 9122088 49.47 µM -0.413020428434608 0.389931874789489 no 2074 0.339795823369292 3136 16876704 SGTC_923 1900-2434 73.3 µM -0.413085810959492 0.389907187922095 no 2075 0.339771872370026 3087 5910570 SGTC_1645 Cervolide 78 µM -0.413802467228087 0.389636624898524 no 2076 0.339509388470664 3189 23173 A fragrance. SGTC_1222 0366-0074 1.18 µM -0.414099577601178 0.389524470925092 no 2077 0.339400591070824 3253 286520 SGTC_1773 st048542 73.5835 µM -0.414247516732265 0.389468629919031 no 2078 0.339346422952359 3120 3237138 SGTC_3042 9091578 49.47 µM -0.414375715501535 0.389420241942436 no 2079 0.339299485479421 3233 25236497 SGTC_2990 9074105 71.4286 µM -0.415774371651458 0.388892437795908 no 2080 0.338787557005899 3200 6502001 SGTC_50 0929-0078 56.389 µM -0.416024202312515 0.388798181951836 no 2081 0.338696146657891 3109 1377751 SGTC_2190 6049624 200 µM -0.417065677726554 0.388405325801843 no 2082 0.338315184426488 3208 2265554 SGTC_1992 st073643 23.3 µM -0.417258011649753 0.388332787772737 no 2083 0.338244848514469 3122 3161292 SGTC_3220 9131269 49.47 µM -0.417917547834218 0.388084075726974 no 2084 0.338003701078944 3237 17722206 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.418535206427988 0.387851197394805 no 2085 0.337777925685684 3270 756377 SGTC_2689 tacrolimus 100 µM -0.418631973987584 0.387814716380343 no 2086 0.33774255911067 3196 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_626 0214-0009 33 µM -0.418918645163256 0.387706648213336 no 2087 0.337637795036063 3266 3437874 SGTC_2931 9014674 55.67 µM -0.420455750091016 0.387127345023953 no 2088 0.337076274288989 3101 2996810 SGTC_2691 st077356 60.2 µM -0.420864263254592 0.38697342704339 no 2089 0.33692710106938 3294 2839272 SGTC_133 0724-0033 378.92 µM -0.42122580429393 0.386837221858439 no 2090 0.336795101644927 3047 280309 SGTC_1261 0712-0010 12.7 µM -0.421371838968864 0.386782209426981 no 2091 0.336741789764131 3315 2840123 SGTC_1642 st009582 77.7 µM -0.421414398928182 0.386766177177526 no 2092 0.336726253307925 3289 6739311 SGTC_2617 dihydrotanshinone i 20.83 µM -0.42165789245205 0.386674457382078 no 2093 0.336637371681005 3137 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1482 3346-2049 8.48 µM -0.42207350551923 0.386517917759382 no 2094 0.336485682915341 3235 3826804 SGTC_2462 5162487 171.77 µM -0.422353719208223 0.386412386394136 no 2095 0.336383426679023 3249 2259986 SGTC_794 k038-0031 316 µM -0.42391234374781 0.385825545846107 no 2096 0.33581487079542 3264 6624242 SGTC_2678 equilin 100 µM -0.424592932675726 0.385569377926551 no 2097 0.335566722931428 3257 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1035 k081-0041 55.2 µM -0.425569358336927 0.385201946747761 no 2098 0.335210836002962 3296 731709 SGTC_2942 9052777 62.25 µM -0.426055589695798 0.385019015199241 no 2099 0.335033669872085 3181 6469503 SGTC_971 1315-0384 26.7 µM -0.426698207687617 0.38477728662325 no 2100 0.334799578090462 3167 6769120 SGTC_515 4092-1064 102 µM -0.427326227807636 0.384541092481648 no 2101 0.334570866005754 3352 717353 SGTC_3294 9122953 26.2835 µM -0.428130961620441 0.384238500157541 no 2102 0.334277888121797 3150 16459826 SGTC_2276 7947513 42.08 µM -0.428630242986552 0.38405079811021 no 2103 0.334096166441971 3205 2105100 SGTC_1754 st042065 16.137 µM -0.429011256890489 0.383907576347969 no 2104 0.333957516311675 3246 1126236 YIL048W NEO1 SGTC_1504 k297-0033 30 µM -0.429126321666723 0.383864327026726 no 2105 0.333915648944599 3096 4388117 SGTC_645 0845-0943 5.41 µM -0.429380360538549 0.383768846726959 no 2106 0.333823221907682 3199 1885106 SGTC_571 k831-0106 44.2 µM -0.430826907150026 0.38322529802313 no 2107 0.333297116716837 3287 4783639 SGTC_2477 5967686 25.23 µM -0.431813517344095 0.382854704979657 no 2108 0.332938477149909 3104 776118 SGTC_3299 9121982 43.1275 µM -0.433322022033976 0.382288283981904 no 2109 0.332390420794719 3176 17594604 YPL160W CDC60 SGTC_996 3970-0799 1.8 µM -0.433984500640869 0.382039612649217 no 2110 0.332149848140067 3205 6615648 YGL040C HEM2 SGTC_635 k038-0028 24.7 µM -0.434546284133772 0.381828776865369 no 2111 0.331945896119612 3181 4035102 SGTC_1540 guanosine 70.6 µM -0.434957255125762 0.381674562787578 no 2112 0.331796727171521 3219 6802 Guanosine is a purine nucleoside SGTC_131 0141-0277 33.849 µM -0.438404745626494 0.380381657056666 no 2113 0.33054645346415 3299 1547771 SGTC_1086 cerivastatin 2.18 µM -0.438450371786898 0.380364554886373 no 2114 0.330529919224689 3246 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2029 5175081 200 µM -0.439158525959989 0.380099145649419 no 2115 0.330273337146506 3182 1380876 SGTC_1525 8-methoxypsoralen 92.5 µM -0.439287561475453 0.380050790480883 no 2116 0.330226592922131 3381 4114 Related to psoralen; DNA damaging agent. SGTC_2305 7443522 69.23 µM -0.440293987966119 0.379673703500651 no 2117 0.329862097250053 3184 5415886 SGTC_2263 7948595 193.29 µM -0.440772842493659 0.379494326856719 no 2118 0.329688728043032 3159 2971371 SGTC_1469 k284-2957 126 µM -0.441197690603228 0.379335202472195 no 2119 0.329534942481589 3218 23884841 SGTC_1153 4055-0057 267 µM -0.444258728093345 0.378189314405482 no 2120 0.32842776836662 3185 882706 SGTC_2260 7964312 200 µM -0.444434485720939 0.378123552593725 no 2121 0.328364242609841 3324 231951 SGTC_640 3381-0960 37.1 µM -0.444693976254442 0.378026467572188 no 2122 0.328270461541181 3261 1745025 SGTC_3039 9090270 49.47 µM -0.445152987512343 0.377854753322116 no 2123 0.328104599271347 3323 17173750 SGTC_525 k781-2675 26.7 µM -0.445191502420964 0.377840346147937 no 2124 0.32809068357125 3296 3651118 YDL195W SEC31 SGTC_3135 9127742 49.47 µM -0.445737562930905 0.377636100969539 no 2125 0.327893413852001 3212 3643468 SGTC_1924 st058459 75.1 µM -0.445843490396436 0.377596484459528 no 2126 0.327855152073711 3272 688683 SGTC_2185 6113692 200 µM -0.449903665915312 0.376078966940257 no 2127 0.326389952075612 3301 874150 SGTC_2244 6635614 200 µM -0.450151167011792 0.375986523426882 no 2128 0.326300722358178 3052 836499 SGTC_2487 5918373 44.05 µM -0.451059507103338 0.375647312618569 no 2129 0.325973330527294 3366 2876279 SGTC_619 1652-1634 108 µM -0.452921300455595 0.374952344516569 no 2130 0.325302706167063 3208 5400454 SGTC_2847 9005661 71.43 µM -0.453307892842994 0.374808088559431 no 2131 0.325163525073243 3265 2991449 SGTC_1852 st056254 31.4 µM -0.45334264353982 0.374795122283795 no 2132 0.325151015312591 3170 442583 SGTC_303 1348-1668 34.2 µM -0.45360901616462 0.374695737298523 no 2133 0.325055131471142 3236 5380509 SGTC_1303 1160-0052 261 µM -0.455625062568827 0.373943810390963 no 2134 0.324329808775627 3274 3562476 SGTC_2161 5662504 8.5105 µM -0.455637519939704 0.373939165639983 no 2135 0.324325328995278 3204 2859334 SGTC_981 1488-1094 54.9 µM -0.455701657173776 0.373915252257737 no 2136 0.324302265083166 3219 3449522 SGTC_588 3970-1144 52.9 µM -0.456164726240745 0.373742612700666 no 2137 0.324135764279247 3275 1888707 SGTC_3223 9129970 49.47 µM -0.460097191000828 0.372277551017084 no 2138 0.322723230123543 3184 17248386 SGTC_1943 st076331 65.2 µM -0.460666346784826 0.372065661336917 no 2139 0.322519001524127 3321 24208415 SGTC_1465 k213-0056 144 µM -0.460874079549923 0.371988334635542 no 2140 0.322444474683216 3175 24048857 YMR208W ERG12 SGTC_1351 1496-0003 46.5 µM -0.462109317373798 0.3715286349026 no 2141 0.322001464426184 3337 3891978 SGTC_2472 5377652 49.4 µM -0.465116963238879 0.370410092057979 no 2142 0.320923849424831 3254 1610903 SGTC_3035 9091303 49.47 µM -0.46515742589755 0.370395051446385 no 2143 0.320909362236397 3288 25237002 SGTC_2522 biochanin a 4.94 µM -0.466118999558763 0.370037677623813 no 2144 0.320565162149284 3339 5280373 A possible chelator. SGTC_763 3453-1109 128 µM -0.466593849707121 0.369861238470368 no 2145 0.320395244045392 3367 1560353 SGTC_77 0828-0286 12.516 µM -0.466937807152753 0.369733451970003 no 2146 0.32027218746672 3321 745345 SGTC_2684 capsaicin 100 µM -0.467368798834363 0.369573350960814 no 2147 0.320118020818874 3329 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1745 st081495 74 µM -0.4681459844941 0.3692847060152 no 2148 0.319840098339245 3302 13842402 YBL026W LSM2 SGTC_528 3492-0019 172 µM -0.468865058601901 0.369017709178207 no 2149 0.319583046657443 3320 2869262 SGTC_79 0052-0007 94.094 µM -0.469346150755708 0.368839111842088 no 2150 0.319411116167857 3364 2801472 SGTC_132 0417-1715 25.805 µM -0.470242734253636 0.368506345957154 no 2151 0.319090802906727 3389 6769098 SGTC_632 0781-2353 4.65 µM -0.470921977275131 0.3682543113522 no 2152 0.318848226546228 3321 6811515 YHR007C ERG11 SGTC_3180 9109287 49.47 µM -0.471723550954347 0.367956958613392 no 2153 0.318562062347796 3317 18891271 SGTC_1963 st076565 50.3 µM -0.474079085763003 0.367083604973707 no 2154 0.317721755992113 3213 4914280 SGTC_2630 antimycin a 100 µM -0.476435386012477 0.366210655130322 no 2155 0.316882114887115 3217 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1109 tnp00067 928.257 nM -0.476519148601552 0.366179635912415 no 2156 0.31685228434863 3278 676295 SGTC_1594 piperine 70.1 µM -0.478406262246384 0.365481026355276 no 2157 0.316180538677441 3235 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_101 0490-5701 117.494 µM -0.480138782114938 0.364840040047488 no 2158 0.315564356603563 3314 4661669 SGTC_2893 9048488 25.97 µM -0.480982444483614 0.36452804397908 no 2159 0.315264487946228 3273 6467338 SGTC_892 0929-0076 29 µM -0.481159834405438 0.364462454550095 no 2160 0.315201452512842 3270 5751038 SGTC_2971 9092186 9.93 µM -0.483899835022579 0.363449852049706 no 2161 0.314228478736251 3208 25236400 SGTC_164 4100-3994 89.624 µM -0.48414749865853 0.363358371641321 no 2162 0.31414059686604 3397 4615967 SGTC_215 1287-0124 461.5 µM -0.48423282416473 0.363326856456631 no 2163 0.314110322091639 3288 5560863 SGTC_3306 9127676 59.7925 µM -0.484871474123316 0.363090998920131 no 2164 0.313883759200872 3312 41905287 SGTC_2898 9056270 58.44 µM -0.485124078760764 0.362997724725134 no 2165 0.313794166342441 3309 19154699 SGTC_1227 3909-8010 46.6 µM -0.485372777554859 0.362905900700296 no 2166 0.313705969518884 3246 15982272 SGTC_511 blebbistatin 171 µM -0.486098972675234 0.3626378216509 no 2167 0.313448497636535 3398 3476986 A myosin inhibitor. SGTC_1591 genipin 88.4 µM -0.486271612404037 0.362574100615334 no 2168 0.313387301728376 3362 442424 A DNA cross-linking agent. SGTC_1938 st074717 56.4 µM -0.487402335912709 0.362156846635929 no 2169 0.312986619251091 3292 17250979 SGTC_2941 9056145 11.23 µM -0.48807670781099 0.361908071180916 no 2170 0.312747754315685 3324 2119517 SGTC_3105 9121040 49.47 µM -0.48833756566163 0.361811856492439 no 2171 0.312655378613025 3281 41448907 SGTC_2877 9040724 71.43 µM -0.490510313003109 0.361010801246331 no 2172 0.311886416944218 3390 6463895 SGTC_1906 st060206 94.7 µM -0.491434844847352 0.360670126532044 no 2173 0.311559462156265 3362 5133468 SGTC_942 3253-1115 227 µM -0.494561369773638 0.359518874163503 no 2174 0.310454888165227 3415 46497897 SGTC_426 0988-0037 14.6 µM -0.494698626789794 0.359468362352584 no 2175 0.310406435504819 3412 5383008 SGTC_384 k007-0144 5.16 µM -0.495094493789668 0.359322693508478 no 2176 0.310266710190443 3300 6824886 SGTC_2759 disulfiram 3.38 µM -0.495140785891491 0.359305660543951 no 2177 0.310250372706639 3240 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2444 5485484 36.41 µM -0.495173198667818 0.359293734579397 no 2178 0.310238933759832 3366 6790631 SGTC_2642 cholecalciferol 100 µM -0.495836523305648 0.359049700880179 no 2179 0.310004877049112 3346 9821465 A vitamin D precursor, similar to steriods. SGTC_3198 9112019 49.47 µM -0.496267133377663 0.358891312440228 no 2180 0.30985297578553 3343 45595555 SGTC_1974 st069448 26.9 µM -0.496715289089851 0.358726496065072 no 2181 0.309694919620782 3367 6323587 YNR016C ACC1 SGTC_9 0092-0002 10.449 µM -0.497058204397259 0.358600401280435 no 2182 0.309574003541774 3358 759368 SGTC_546 peri-Naphthalide 147 µM -0.497972312264711 0.358264346288584 no 2183 0.309251778784549 3271 223824 A penicillin ester. SGTC_357 1325-0123 420 µM -0.499480677766161 0.357710063464488 no 2184 0.30872039780939 3371 1098503 SGTC_877 0771-0151 33.1 µM -0.50025913960595 0.357424117418563 no 2185 0.308446310567296 3317 6166523 SGTC_2438 5259590 200 µM -0.501128660137348 0.357104818147363 no 2186 0.308140288810857 3345 1201127 SGTC_3243 9134147 49.47 µM -0.501486382823539 0.356973486749447 no 2187 0.308014429473407 3366 24282180 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.503037601052957 0.356404181366157 no 2188 0.307468918078907 3371 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_382 3229-0966 23.2 µM -0.503110816451605 0.35637731881824 no 2189 0.307443181188173 3424 5722370 SGTC_2655 perillic acid 100 µM -0.504627091552715 0.355821161619986 no 2190 0.306910389004536 3291 5702197 An apoptosis inducer. SGTC_2925 9010536 32.5 µM -0.506435411573914 0.355158285837494 no 2191 0.306275510296059 3306 2994177 SGTC_2026 5148700 152 µM -0.50678344702226 0.355030756709281 no 2192 0.306153386012515 3280 79838 SGTC_2187 6125751 200 µM -0.508739038007437 0.35431448027424 no 2193 0.305467577584154 3341 874498 SGTC_792 4534-1957 155 µM -0.508918897530652 0.354248628756141 no 2194 0.305404536658679 3291 1717904 SGTC_623 k072-0108 16.9 µM -0.511381328600832 0.353347504020489 no 2195 0.30454203325791 3347 5382803 SGTC_3152 9099253 49.47 µM -0.511831007693311 0.353183032867178 no 2196 0.30438464350597 3359 25236131 SGTC_3322 9139058 2.11 µM -0.511914754891155 0.353152405166595 no 2197 0.304355335601557 3417 4908926 YPR165W RHO1 SGTC_2583 asiatic acid 100 µM -0.512420317112243 0.35296753312048 no 2198 0.304178437337928 3445 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_993 3909-8757 62.7 µM -0.51283120672474 0.352817306151736 no 2199 0.304034699154881 3283 4288324 YLR208W SEC13 SGTC_348 k064-0012 10.7 µM -0.514052075081887 0.35237107511694 no 2200 0.303607791419091 3314 5066323 SGTC_1883 5-benzylidenerhodanine 20 µM -0.514581135880572 0.352177764862747 no 2201 0.303422874982397 3376 1273210 SGTC_3214 9129694 49.47 µM -0.514722623167847 0.352126074167746 no 2202 0.303373431113815 3410 17158655 SGTC_561 1550-0330 72.9 µM -0.515298937163602 0.351915552952158 no 2203 0.303172070771978 3308 6812934 SGTC_2696 st077691 74.316 µM -0.515337206048886 0.351901575352172 no 2204 0.30315870199007 3413 757133 SGTC_687 k029-0044 34.9 µM -0.515437811048597 0.351864830620886 no 2205 0.303123558082387 3402 5829338 SGTC_2430 5571206 200 µM -0.516200365553982 0.351586362031283 no 2206 0.302857237502283 3439 1731771 SGTC_1922 5578187 25 µM -0.518202012185678 0.350855782648519 no 2207 0.302158665505868 3475 1350412 SGTC_1564 D-Arginine 115 µM -0.518649255918741 0.350692618748513 no 2208 0.302002676956696 3322 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2145 5634607 200 µM -0.518871433028219 0.350611574111769 no 2209 0.301925200029995 3297 308662 SGTC_115 0527-0192 112.043 µM -0.519131554510486 0.350516696959304 no 2210 0.301834502606407 3409 4233931 SGTC_3353 9151644 39.2805 µM -0.519877449485962 0.350244689678046 no 2211 0.301574496844274 3408 4909158 SGTC_2993 9054257 71.4286 µM -0.521109676226045 0.349795498929839 no 2212 0.301145185321541 3338 6470217 YGL055W OLE1 SGTC_1418 3966-3099 2.4 µM -0.521727152037287 0.349570485899956 no 2213 0.300930158500455 3405 740335 SGTC_105 0111-0055 734.78 µM -0.524836604784103 0.348438181395501 no 2214 0.299848391346966 3368 5179370 SGTC_842 0271-0008 11.1 µM -0.525338060464421 0.34825570282625 no 2215 0.299674101737987 3435 1221709 SGTC_974 1326-0144 138 µM -0.525806995430399 0.348085090247738 no 2216 0.299511156804455 3337 5411856 SGTC_999 SEC7.066 22.7 µM -0.525974720311841 0.348024074377996 no 2217 0.299452885725623 3328 740511 YDR170C SEC7 SGTC_1516 st013856 110 µM -0.527403111693677 0.347504605965499 no 2218 0.29895684155298 3383 5281404 A mutagen and neurotoxin. SGTC_2279 7948423 32.93 µM -0.527746415583872 0.347379797991613 no 2219 0.29883767645259 3467 1247112 SGTC_1353 1498-1206 8.11 µM -0.528643682548725 0.347053675157818 no 2220 0.298526325769543 3451 6756808 SGTC_2455 5377712 9.75 µM -0.529022032882562 0.346916192954848 no 2221 0.298395082851495 3375 2243908 SGTC_3189 9110682 49.47 µM -0.529639638800574 0.34669181509219 no 2222 0.298180902918654 3397 17122418 SGTC_1349 flufenamic acid 69 µM -0.529697844341436 0.346670671636464 no 2223 0.298160721394646 3358 3371 A non-steroidal anti-inflammatory. SGTC_2297 7971671 152.32 µM -0.530675789026459 0.346315499774287 no 2224 0.297821733120579 3451 909016 SGTC_3099 9120367 49.47 µM -0.533559153581004 0.345269101204782 no 2225 0.296823287334313 3415 24824940 SGTC_524 r073-0010 27.8 µM -0.533607234461502 0.345251662222264 no 2226 0.296806650976043 3332 2772106 SGTC_3032 9089427 49.47 µM -0.535436249909761 0.344588520804207 no 2227 0.296174114609512 3406 17173707 SGTC_2825 7998094 58.44 µM -0.535602919798767 0.344528115431841 no 2228 0.296116505195233 3349 2987815 SGTC_152 4469-0003 551.229 µM -0.536297890575379 0.344276283236179 no 2229 0.295876344123445 3445 697280 SGTC_1297 1068-0111 14.1 µM -0.537375708350148 0.34388585775674 no 2230 0.295504059657744 3343 767057 SGTC_279 1273-0055 2.93 µM -0.537392219542496 0.343879878085047 no 2231 0.295498358272449 3402 2847562 SGTC_705 1124-0212 310 µM -0.537913504859511 0.343691110166313 no 2232 0.295318382240909 3453 9554485 SGTC_2545 solidagenone 89.61 µM -0.53845467756339 0.343495181849099 no 2233 0.295131593386363 3296 6708572 An anti ulcer agent SGTC_490 phenamil 164 µM -0.538471797086372 0.343488984514721 no 2234 0.295125685372892 3360 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2262 9014885 67.46 µM -0.53897424529202 0.343307115041009 no 2235 0.294952312818294 3378 6457424 SGTC_1219 1469-0211 33.1 µM -0.540131639813838 0.342888314969098 no 2236 0.294553126051622 3416 6822282 SGTC_2937 9044753 11.33 µM -0.540634357715369 0.342706467940432 no 2237 0.294379815731166 3391 6465530 YGL099W LSG1 SGTC_2569 tetrandrine 100 µM -0.540819134497836 0.34263963820255 no 2238 0.294316126386549 3333 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1705 st027868 56.3335 µM -0.542537577594529 0.34201835089387 no 2239 0.293724113949794 3396 292948 SGTC_2899 9053889 58.44 µM -0.542633106086173 0.341983825973623 no 2240 0.293691220071027 3428 6470052 SGTC_1260 0700-1617 7.75 µM -0.543533062078424 0.341658638067443 no 2241 0.293381416737083 3413 2853078 SGTC_578 3460-0051 92 µM -0.543772546446261 0.341572123149886 no 2242 0.293299001492733 3487 2876744 SGTC_2911 7942208 15.64 µM -0.544324635154688 0.341372710076243 no 2243 0.293109048666127 3410 1243384 SGTC_11 0438-0307 1.3 µM -0.545084660502566 0.341098263249436 no 2244 0.292847646089444 3447 4011476 SGTC_2520 obtusaquinone 4.71 µM -0.545109830534969 0.341089175732328 no 2245 0.292838990978044 3515 5967872 SGTC_3007 9078383 71.4286 µM -0.545290209294837 0.341024053560827 no 2246 0.292776968380411 3339 6496995 SGTC_2873 9040596 71.43 µM -0.546495072642654 0.340589183109892 no 2247 0.292362836915383 3446 6463863 SGTC_2570 licareol 100 µM -0.546596260383479 0.340552671126267 no 2248 0.292328069417026 3375 443158 SGTC_846 0335-0850 148 µM -0.54816441180199 0.339987019875111 no 2249 0.291789507999515 3414 6819598 SGTC_3258 9138477 49.47 µM -0.548472511382883 0.339875926892817 no 2250 0.291683749526089 3453 4970355 SGTC_539 4859-0462 2.54 µM -0.549316670126359 0.339571615683619 no 2251 0.291394074593617 3443 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2701 st077767 14.721 µM -0.54982791194664 0.339387368686643 no 2252 0.291218706121477 3410 5721188 SGTC_1782 st039423 80.636 µM -0.550299253923261 0.339217535247079 no 2253 0.291057067941037 3344 2068169 SGTC_2954 9074818 52.69 µM -0.550302120636378 0.339216502415949 no 2254 0.291056084982007 3450 16648742 SGTC_1829 berberine 14.4 µM -0.552431844743586 0.338449531007092 no 2255 0.290326258884156 3480 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2495 cafestol 54.53 µM -0.552631990385803 0.338377487509095 no 2256 0.290257715902475 3481 16667697 An anti-infammatory. SGTC_2546 rhodinyl acetate 100 µM -0.556279613008726 0.337065544844463 no 2257 0.289009860894086 3458 6708682 SGTC_569 4130-2812 160 µM -0.558341634281152 0.336324771008122 no 2258 0.288305559937491 3403 743552 SGTC_3275 9138069 49.47 µM -0.559819822034671 0.335794127844264 no 2259 0.287801170885167 3453 17617007 SGTC_1793 st048256 72.231 µM -0.560077654385208 0.335701604093036 no 2260 0.287713235723843 3425 672022 SGTC_1909 st060837 51.5 µM -0.560368200764866 0.335597352769793 no 2261 0.28761415847688 3364 678937 SGTC_506 n9-isopropylolomoucine 153 µM -0.561024906600396 0.335361765930568 no 2262 0.287390279120065 3475 6610355 SGTC_1996 st072960 66.8 µM -0.564121062738753 0.334251923271482 no 2263 0.286335872251449 3499 1719405 SGTC_2377 9073351 62.6 µM -0.565741304140229 0.333671710669202 no 2264 0.285784826300244 3377 7337946 YHR072W ERG7 SGTC_618 k072-0232 33.2 µM -0.565752152173087 0.333667827299086 no 2265 0.285781138572257 3425 5872756 YGL099W LSG1 SGTC_1117 retinoic acid 1.10837 µM -0.566262248324221 0.33348524361257 no 2266 0.285607759802175 3508 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2273 7815444 169.05 µM -0.566672773005224 0.333338329152435 no 2267 0.285468261170415 3476 2824616 SGTC_178 4092-0806 87.505 µM -0.566782175633724 0.333299181548931 no 2268 0.285431091007489 3466 2169044 SGTC_2811 7967822 32.47 µM -0.566939902153258 0.333242745376783 no 2269 0.28537750658548 3468 2232244 SGTC_1391 3442-0225 151 µM -0.569124771107342 0.33246136563417 no 2270 0.284635734454553 3416 5227075 SGTC_1135 dihydrocapsaicin 536.708 nM -0.569422669723397 0.332354883745844 no 2271 0.284534667987103 3440 107982 A Capsaicinoid. SGTC_159 3970-0959 50 µM -0.572226234635585 0.331353431868712 no 2272 0.283584358186166 3569 6615653 SGTC_1859 st055998 20 µM -0.573810576156219 0.33078802690528 no 2273 0.283047995542831 3526 676301 SGTC_2033 5192550 145 µM -0.576555494560179 0.329809359944277 no 2274 0.282119885670391 3403 182073 SGTC_2525 harmine 47.85 µM -0.576990654829749 0.329654315612907 no 2275 0.281972884246847 3398 5280953 A monoamine oxidase inhibitor SGTC_3292 9120825 59.784 µM -0.577023342754369 0.32964267033286 no 2276 0.281961843434056 3538 24824900 SGTC_1817 st052116 64.4 µM -0.578835351947518 0.328997389218633 no 2277 0.281350137436773 3496 4361398 SGTC_601 0986-0029 62.9 µM -0.57891433094787 0.328969275291548 no 2278 0.28132348993446 3495 24747981 SGTC_2715 st079500 56.4 µM -0.579924752834453 0.328609683740356 no 2279 0.280982681287257 3445 28246688 SGTC_3149 9097855 49.47 µM -0.579991997035637 0.328585758327392 no 2280 0.280960007343901 3480 25236625 YMR079W SEC14 SGTC_1357 1503-1303 39.5 µM -0.581703630497312 0.327976997840619 no 2281 0.280383162846189 3486 292895 SGTC_2639 lactacystin 53 µM -0.583222886356072 0.327437041002996 no 2282 0.279871633167326 3527 3870 A proteasome inhibitor. SGTC_1255 0566-0045 221 µM -0.583565767712578 0.327315227829006 no 2283 0.27975624849985 3522 2788469 SGTC_651 3253-0966 34.4 µM -0.583732105764738 0.327256140640702 no 2284 0.279700281591054 3448 781462 SGTC_948 3448-0295 75.3 µM -0.584121176552301 0.327117950451059 no 2285 0.279569394166166 3508 678569 SGTC_2152 5568786 200 µM -0.58722915897256 0.32601490911683 no 2286 0.278524905681201 3476 5399883 SGTC_3261 9137475 49.47 µM -0.588071032230864 0.325716384672027 no 2287 0.278242307902961 3395 17027690 SGTC_1900 st060200 72.8 µM -0.591883957771496 0.324365739763008 no 2288 0.276964148466938 3489 688945 SGTC_3062 9077494 49.47 µM -0.59357606284189 0.323767086905281 no 2289 0.276397847549356 3479 16459633 SGTC_788 1182-0090 188 µM -0.595705306645534 0.323014425489743 no 2290 0.275686056252097 3579 5715185 SGTC_196 k015-0023 18.111 µM -0.59621145372774 0.322835615155935 no 2291 0.275516987479972 3491 5211998 SGTC_1765 st044815 90.4 µM -0.599020630712999 0.321843941644635 no 2292 0.274579563543543 3474 645695 SGTC_1027 k015-0025 8.67 µM -0.599682232574752 0.321610572335272 no 2293 0.274359015767343 3506 3598955 SGTC_890 0929-0006 47.2 µM -0.600591592029796 0.321289925412509 no 2294 0.274056019724924 3436 1378169 SGTC_2389 9091542 195.52 µM -0.602224901522737 0.32071434279089 no 2295 0.273512221071825 3463 3626624 YOL127W RPL25 SGTC_1413 3910-0535 34.4 µM -0.603080635920981 0.320412951577101 no 2296 0.273227523828041 3525 2876951 SGTC_2087 5276107 200 µM -0.604032625415031 0.320077798272272 no 2297 0.27291097574897 3512 144405 SGTC_3342 9147791 14.508 µM -0.604551280885669 0.319895264414054 no 2298 0.272738593065888 3510 1838168 SGTC_2852 9023854 51.95 µM -0.606776101633035 0.319112763588052 no 2299 0.271999755044192 3580 19798528 SGTC_1879 gemcitabine 100 µM -0.606780792429592 0.319111114618326 no 2300 0.271998198335415 3515 60750 A nucleoside analog which inhibits DNA replication. SGTC_2204 7233102 200 µM -0.609254626324481 0.318241979757341 no 2301 0.271177838597355 3464 2172480 SGTC_2842 9000675 19.48 µM -0.609785729063892 0.318055517018578 no 2302 0.271001878100298 3483 2989072 SGTC_2366 9070441 60.58 µM -0.610615098897278 0.317764429111595 no 2303 0.270727212227281 3503 6837235 SGTC_1873 rapamycin 2 nM -0.611445782925844 0.317472992810726 no 2304 0.27045225052017 3530 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1308 1187-1617 41.4 µM -0.613090563717772 0.316896273476618 no 2305 0.269908229636383 3535 2882570 SGTC_2586 curcumin 80 µM -0.613238244474595 0.316844513021687 no 2306 0.269859410173228 3523 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1093 fluphenazine 7.97 µM -0.615082957253576 0.316198264140835 no 2307 0.269249968269982 3572 6602611 An atypical antipsychotic. SGTC_69 0096-0274 206.684 µM -0.615832708906585 0.315935767686135 no 2308 0.269002468586668 3675 6741392 SGTC_1723 st034307 2.5525 µM -0.616707531079116 0.315629599933418 no 2309 0.268713826446667 3533 867466 SGTC_20 0481-0013 4.944 µM -0.61745017373178 0.31536979124787 no 2310 0.268468918288768 3530 182045 SGTC_2497 7-hydroxyflavone 100 µM -0.618729626543911 0.31492239714206 no 2311 0.26804724465408 3555 5281894 SGTC_1810 st050138 53 µM -0.620852073557509 0.314180826930276 no 2312 0.267348478630473 3556 3444541 SGTC_2968 9090663 33.37 µM -0.621162186551082 0.314072538003925 no 2313 0.267246458182552 3459 25236811 SGTC_1884 5633444 25 µM -0.622459656789399 0.313619645648571 no 2314 0.266819831782172 3575 5724239 SGTC_2105 5350118 200 µM -0.622979602732655 0.313438233125576 no 2315 0.266648962908426 3557 2133313 SGTC_3107 9121808 49.47 µM -0.623183800994143 0.313366999361343 no 2316 0.266581872743889 3508 662681 SGTC_1406 3909-7906 11.9 µM -0.624243686372859 0.312997374387906 no 2317 0.266233780306515 3561 X1406 SGTC_1620 st003704 16.5 µM -0.624698232172714 0.312838913392137 no 2318 0.266084566808886 3551 2834414 SGTC_1510 1123-0200 71.5 µM -0.624899681772892 0.31276869631217 no 2319 0.266018450607278 3654 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1774 st048371 48.465 µM -0.625784582890184 0.312460336514496 no 2320 0.26572812271056 3505 4242727 SGTC_1157 4092-0394 27.6 µM -0.626715739967672 0.312135999725136 no 2321 0.265422792211122 3644 3659885 SGTC_3183 9108214 49.47 µM -0.626738771712881 0.312127979246423 no 2322 0.265415242257421 3490 4974831 SGTC_2343 7990716 14.84 µM -0.626848741107141 0.312089685191771 no 2323 0.265379195087621 3534 6456862 SGTC_52 0329-0193 875 nM -0.626918160744659 0.312065512607685 no 2324 0.265356441113313 3629 3739292 SGTC_1199 1638-0010 4.46 µM -0.627235193824167 0.311955128934203 no 2325 0.265252538400787 3508 3111136 SGTC_3172 9105863 49.47 µM -0.629863843119824 0.311040544501013 no 2326 0.264391835431503 3538 2348785 SGTC_1286 0929-0070 131 µM -0.630580757801771 0.31079131087017 no 2327 0.264157341849113 3613 1420408 SGTC_471 1-acyl-paf 4 µM -0.632142784417807 0.31024857681361 no 2328 0.263646790135389 3522 16759367 SGTC_589 1227-0070 34.1 µM -0.632681216110368 0.310061591653599 no 2329 0.263470919335936 3580 2841384 SGTC_728 3030-5151 22.5 µM -0.632768820968981 0.310031173109644 no 2330 0.263442310161465 3595 3125388 SGTC_2989 9073649 71.4286 µM -0.633673235055803 0.309717214503627 no 2331 0.263147047798409 3574 21367202 SGTC_341 1486-1430 230 µM -0.634989892146242 0.309260397818943 no 2332 0.262717503681327 3543 2054753 YPL210C SRP72 SGTC_1452 4194-0072 190 µM -0.636058131919191 0.308889986481297 no 2333 0.262369266586646 3609 1343545 SGTC_1433 4060-0023 7.6 µM -0.636059867663655 0.308889384771212 no 2334 0.262368700941106 3582 3840627 SGTC_2950 9072895 21.46 µM -0.636667724792749 0.308678697651788 no 2335 0.262170650473251 3546 17332245 SGTC_2397 5161689 200 µM -0.638466288063941 0.308055673221908 no 2336 0.261585096134916 3633 2259942 SGTC_2837 9008476 45.46 µM -0.639183338830167 0.307807440000783 no 2337 0.261351834778862 3599 2992805 SGTC_489 paxilline 115 µM -0.639735343177346 0.30761640350395 no 2338 0.261172336924138 3572 105008 A toxic potassium channel blocker. SGTC_2076 5212012 200 µM -0.640392848089852 0.30738892365817 no 2339 0.260958615658628 3497 604802 SGTC_2600 tangeritin 87.95 µM -0.640717617219355 0.307276589187865 no 2340 0.260853082994213 3569 68077 A bioactive flavone. SGTC_932 2857-0803 154 µM -0.640829901057125 0.30723775551037 no 2341 0.260816601836781 3648 674898 SGTC_2962 9082311 13.18 µM -0.641383304403082 0.307046391009636 no 2342 0.260636838761621 3543 16459453 SGTC_3069 9117009 49.47 µM -0.641665295768462 0.306948899813212 no 2343 0.260545263496636 3461 41904981 SGTC_2303 7774051 200 µM -0.643166219405323 0.306430224218486 no 2344 0.260058125051456 3585 2953184 SGTC_2921 7974240 10.71 µM -0.643491599410998 0.306317833425692 no 2345 0.259952581975879 3590 2979074 YDR527W RBA50 SGTC_2643 anethole 100 µM -0.645017713507845 0.305790935614279 no 2346 0.259457853362475 3575 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2077 5212015 200 µM -0.645793143889918 0.305523368616274 no 2347 0.259206664379663 3515 780900 SGTC_3295 9122362 53.5725 µM -0.646080229875985 0.305424334169643 no 2348 0.259113699095306 3579 4730473 SGTC_186 3455-3465 67.277 µM -0.646102658236796 0.305416597782993 no 2349 0.259106436983599 3547 755278 SGTC_2565 isoliquiritigenin 100 µM -0.646425317052684 0.305305310219814 no 2350 0.259001974462135 3545 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2539 epi(13)torulosol 80 µM -0.646467981367161 0.305290596308921 no 2351 0.258988163292262 3560 6708597 SGTC_249 wiskostatin 11.211 µM -0.647149892988671 0.305055463865414 no 2352 0.258767468521934 3600 2775510 A n-wasp and actin depolymerizer. SGTC_1218 1348-1416 30.7 µM -0.647863315816007 0.304809552041115 no 2353 0.258536679648803 3588 6787668 SGTC_1251 0490-5699 265 µM -0.648301044657492 0.30465871361985 no 2354 0.258395129248254 3634 3883818 SGTC_698 k064-0052 127 µM -0.650160908026113 0.304018187693058 no 2355 0.257794144678827 3643 5088751 SGTC_1473 k844-0725 134 µM -0.651722492142956 0.303480851473788 no 2356 0.257290105044602 3663 54682906 SGTC_1427 4048-4900 550 nM -0.652817628505421 0.303104271734402 no 2357 0.256936928701151 3603 24132586 SGTC_443 clozapine 122 µM -0.654885256725279 0.302393855987761 no 2358 0.256270816616168 3538 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_671 0560-0003 407 µM -0.65631223745312 0.301903996094092 no 2359 0.255811622665244 3542 3238678 SGTC_1758 st042942 75.2445 µM -0.656903451817421 0.301701146077034 no 2360 0.255621499292078 3581 669317 SGTC_2031 5180455 200 µM -0.657979356803133 0.30133215246317 no 2361 0.255275698012722 3583 29949 SGTC_2128 5255449 168.493 µM -0.659978932649981 0.300646915973684 no 2362 0.254633674468394 3616 736008 SGTC_1279 0874-0590 65.2 µM -0.660407118946451 0.300500271903926 no 2363 0.254496302489634 3619 3523074 SGTC_1268 0828-0275 2.46 µM -0.660447467488409 0.300486455111444 no 2364 0.254483359754708 3637 745337 SGTC_3248 9135562 49.47 µM -0.66206971833614 0.299931175917133 no 2365 0.253963270823865 3639 17650701 SGTC_1756 st041558 35.5 µM -0.66522544046027 0.298852338472649 no 2366 0.252953155474081 3696 3955792 SGTC_2544 sphondin 68.51 µM -0.665848204576488 0.298639644418292 no 2367 0.25275406494363 3643 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_432 NS 1619 61.3 µM -0.665879091720941 0.298629097252963 no 2368 0.252744192826538 3620 4552 A K+/calcium channel activator. SGTC_1899 st063254 59.6 µM -0.6669046906776 0.298278977826982 no 2369 0.252416507284584 3571 3093813 SGTC_764 1951-2361 146 µM -0.667292514604538 0.298146631040634 no 2370 0.252292653386389 3600 5438930 SGTC_888 0916-0002 6.97 µM -0.667370417206566 0.298120049628447 no 2371 0.25226777858799 3656 2802138 YIL048W NEO1 SGTC_2518 prenyletin 46.28 µM -0.668728581886564 0.297656799231003 no 2372 0.251834315811719 3561 3873459 A coumarin with calcium channel inhibitory activity. SGTC_829 1635-0120 117 µM -0.669772744539578 0.297300873910389 no 2373 0.251501335364624 3628 285054 SGTC_2740 felodipine 17.08 µM -0.670318786749257 0.297114821139237 no 2374 0.251327296771222 3575 3333 L-type calcium channel blocker SGTC_3091 9116372 49.47 µM -0.670822034241619 0.296943396953948 no 2375 0.251166954423141 3640 17169793 SGTC_368 fentichlor 4.58 µM -0.671065857692058 0.296860358198584 no 2376 0.251089288004166 3592 7329 A pesticide. SGTC_3003 9075612 71.4286 µM -0.671387185509383 0.296750940077903 no 2377 0.250986953102699 3623 6501993 SGTC_1502 4534-4282 27.7 µM -0.671754239424306 0.296625973964612 no 2378 0.250870082589492 3613 3278949 SGTC_1042 0350-0096 82 µM -0.672014485682656 0.296537385883104 no 2379 0.2507872372494 3636 3122515 SGTC_2415 st077333 57.7 µM -0.673094932022329 0.296169730588442 no 2380 0.250443448958607 3675 2766255 SGTC_2371 9071574 200 µM -0.674243265063303 0.295779204152709 no 2381 0.250078333711295 3605 45596039 SGTC_717 1532-0246 73.2 µM -0.674408785834082 0.295722933169782 no 2382 0.250025729279964 3617 9561992 SGTC_1162 k048-0130 20.1 µM -0.675583105014853 0.295323849109599 no 2383 0.249652685602565 3625 6797406 SGTC_2872 9044037 25.97 µM -0.676372283979946 0.295055791543329 no 2384 0.249402154856616 3627 6465195 SGTC_1860 st056228 74.6 µM -0.677711080599119 0.294601303844934 no 2385 0.24897744971206 3617 688679 SGTC_1903 st060211 78.3 µM -0.678532098838186 0.294322748713923 no 2386 0.248717189399765 3668 688960 SGTC_2307 7538926 6.34 µM -0.678876334190969 0.294205992717898 no 2387 0.24860811095001 3648 96582 SGTC_145 3737-0113 38.366 µM -0.68061304862172 0.29361726931834 no 2388 0.248058184069173 3678 6849351 SGTC_1290 0986-0249 10.2 µM -0.681314272360587 0.293379718333809 no 2389 0.247836327140328 3600 53329 SGTC_2121 5257820 149.641 µM -0.681844748534008 0.29320007005947 no 2390 0.247668562643796 3685 791256 SGTC_2782 7736369 71.43 µM -0.682207063087272 0.293077399837028 no 2391 0.247554014573596 3699 2950836 YOL077C BRX1 SGTC_3331 9141060 1.957 µM -0.68223245723823 0.293068802935119 no 2392 0.24754598711141 3637 4906567 YPR165W RHO1 SGTC_2380 9035439 200 µM -0.685413476193845 0.291992831335079 no 2393 0.246541521279987 3721 6462575 SGTC_785 1270-0111 65.3 µM -0.6856548302786 0.291911269051967 no 2394 0.246465398465624 3651 6741994 SGTC_24 0417-1663 219 µM -0.687442043555432 0.291307635438848 no 2395 0.245902105490183 3633 4329390 SGTC_927 2425-1185 123 µM -0.687666973878788 0.291231706220903 no 2396 0.245831261046122 3642 730375 SGTC_72 0744-0168 198.391 µM -0.687718500064663 0.291214313944194 no 2397 0.245815033811852 3590 677577 SGTC_819 1013-0258 27.7 µM -0.68850719314509 0.29094815706115 no 2398 0.245566721058146 3679 5753198 SGTC_2325 6158266 200 µM -0.689332804940326 0.290669663216065 no 2399 0.245306929203635 3668 3623240 SGTC_108 0509-0257 621.132 µM -0.689543617166922 0.290598572414143 no 2400 0.245240617476706 3642 536624 SGTC_2506 ethyl hematommate 54.16 µM -0.689625639346043 0.290570914819835 no 2401 0.245214819716494 3662 3940691 An allergen. SGTC_1328 1441-0025 69.2 µM -0.691504579503672 0.289937680256426 no 2402 0.244624251911423 3610 4562601 SGTC_113 0099-0221 2.5 µM -0.691670580189116 0.289881766347557 no 2403 0.24457211325219 3684 89219 SGTC_742 0kpi-0133 140 µM -0.693029845190278 0.289424116315319 no 2404 0.244145411024669 3673 2728852 SGTC_58 0957-0393 9 µM -0.694919270834733 0.288788531235423 no 2405 0.243552947555234 3622 6997992 SGTC_1607 st000305 50.6 µM -0.694937118111027 0.288782530712965 no 2406 0.243547354924576 3668 5457690 SGTC_2414 st077232 92.9 µM -0.695780358616063 0.288499087512141 no 2407 0.243283195770487 3640 729801 SGTC_1571 st070080 73.4 µM -0.696040313495917 0.288411733853433 no 2408 0.243201791808543 3722 4315245 SGTC_2299 7976368 114.88 µM -0.697348810506053 0.287972223905811 no 2409 0.242792264245218 3663 2979718 SGTC_2450 5739737 12.93 µM -0.697475111531463 0.287929817500486 no 2410 0.242752754873876 3676 2262825 SGTC_1742 st038235 28.8875 µM -0.697847759808313 0.287804715561605 no 2411 0.242636203664523 3676 564103 YBR002C RER2 SGTC_102 gallobenzophenone 83.616 µM -0.698296034806489 0.287654258967623 no 2412 0.242496039245528 3696 70837 SGTC_2665 lovastatin 100 µM -0.699314683920547 0.287312503372376 no 2413 0.242177696184343 3678 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_658 3253-0951 102 µM -0.700591600587377 0.2868843708669 no 2414 0.241778960868327 3687 1184878 SGTC_2470 5664817 21.68 µM -0.700687323699274 0.286852288414887 no 2415 0.241749084332672 3696 2859561 SGTC_1792 st045773 43.6 µM -0.700864208721992 0.286793008301084 no 2416 0.241693881290631 3616 2919270 SGTC_573 3702-0553 84.7 µM -0.70114028231494 0.286700498370572 no 2417 0.241607736726577 3656 1222756 SGTC_395 anisomycin 6.25 µM -0.701399600351961 0.286613615974129 no 2418 0.241526835664632 3657 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2247 cerulenin 830 nM -0.702600516580156 0.286211421679279 no 2419 0.24115237024427 3719 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_427 1354-0053 47.3 µM -0.702891090077204 0.286114147101201 no 2420 0.241061812094873 3721 6813657 SGTC_1015 4130-4525 82 µM -0.704977120921367 0.285416273192581 no 2421 0.240412237171703 3690 1363237 SGTC_737 1950-0117 57.9 µM -0.705913768003379 0.285103185283494 no 2422 0.24012088248622 3648 5393513 SGTC_2101 5377231 179.231 µM -0.706725415977673 0.28483201261617 no 2423 0.239868565926889 3692 2844213 SGTC_3141 9094609 49.47 µM -0.709235692519042 0.283994105672653 no 2424 0.239089113773745 3647 25236309 YDL196W YDL196W SGTC_1146 3579-1023 7 µM -0.709352296080612 0.283955213170367 no 2425 0.239052941521947 3742 X1146 SGTC_405 ebelactone b 50 µM -0.709496317521765 0.283907179097595 no 2426 0.239008267944056 3691 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2713 st079149 53.4 µM -0.709686346286797 0.283843806600231 no 2427 0.238949330477526 3726 3103253 SGTC_1489 4065-0444 182 µM -0.711866802799582 0.283117133459287 no 2428 0.238273630442287 3664 2877968 SGTC_2399 5884133 200 µM -0.712012689120551 0.283068546313677 no 2429 0.238228459226715 3713 722445 SGTC_3238 9133470 49.47 µM -0.712148155476168 0.283023433100192 no 2430 0.238186518577123 3693 3534688 SGTC_2784 7567673 72.73 µM -0.712805425722777 0.282804596963108 no 2431 0.237983083863154 3716 3471247 SGTC_3269 9137823 49.47 µM -0.713920230571361 0.282433612016257 no 2432 0.237638253421085 3637 17682936 SGTC_2433 5607874 27.82 µM -0.71448093430251 0.282247109441122 no 2433 0.237464920718848 3699 2252428 SGTC_3127 9126946 49.47 µM -0.714674964222643 0.282182584565358 no 2434 0.237404955601363 3677 27243249 SGTC_315 k915-0449 187 µM -0.716569010968675 0.281553090352461 no 2435 0.236820035690204 3748 20970215 YNL149C PGA2 SGTC_901 1112-0062 60.1 µM -0.716658363202632 0.281523410509311 no 2436 0.236792461502087 3696 1908457 SGTC_2425 5628681 7.85 µM -0.71776220850809 0.281156874323977 no 2437 0.236451959420047 3734 5714958 SGTC_1414 3917-0015 5.4 µM -0.719167734225183 0.280690497810536 no 2438 0.23601878859857 3683 6618702 SGTC_2952 9073731 13.78 µM -0.719336734085224 0.280634446093938 no 2439 0.235966733774886 3736 16457353 SGTC_291 SEC14.278 35.5 µM -0.719504293955182 0.280578877321615 no 2440 0.235915128739733 3690 1068044 SGTC_2857 9024691 58.44 µM -0.719859885587232 0.280460968216357 no 2441 0.235805634353514 3762 16478292 SGTC_183 3914-0051 30.55 µM -0.719904038594602 0.280446329384066 no 2442 0.235792040639393 3699 1596232 SGTC_1419 3993-2473 62.6 µM -0.721740212459375 0.279837877757097 no 2443 0.235227106930275 3767 704026 SGTC_137 0438-0332 85.389 µM -0.722220277954125 0.279678904450515 no 2444 0.235079529016256 3739 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_833 3852-0053 558 µM -0.72243744133704 0.279607005369503 no 2445 0.235012787181636 3748 3123681 SGTC_3187 9109394 49.47 µM -0.722776542263244 0.279494752800872 no 2446 0.23490859065317 3661 17098090 SGTC_1333 1482-0047 286 µM -0.724630522194652 0.278881417076512 no 2447 0.234339364439384 3690 3811116 SGTC_1699 st031318 29.054 µM -0.725285846427281 0.278664778736415 no 2448 0.234138343435686 3779 5340658 SGTC_978 1416-0512 87.4 µM -0.725595450956608 0.278562457586616 no 2449 0.234043405329187 3769 6814003 SGTC_955 1216-0110 33 µM -0.72736105391936 0.277979293749404 no 2450 0.233502402984509 3666 3619719 SGTC_847 0342-0274 5.54 µM -0.727533598923251 0.277922335553769 no 2451 0.233449570314242 3732 18097 SGTC_1155 4088-0394 48.2 µM -0.728455782075477 0.277618013684126 no 2452 0.23316731355063 3690 2326248 SGTC_1350 1495-0454 146 µM -0.729564072073732 0.277252491799514 no 2453 0.23282834502095 3727 1069057 SGTC_466 geldanamycin 89.2 µM -0.731041955236361 0.276765442005244 no 2454 0.232376763358445 3612 5288382 HSP90 inhibitor. SGTC_2810 7959871 45.46 µM -0.731607832615132 0.276579063019852 no 2455 0.23220398306284 3738 2974535 SGTC_2763 lisinopril 49.32 µM -0.73215921372128 0.276397517767516 no 2456 0.232035697730095 3678 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_474 dl-dihydrosphingosine 5 µM -0.73304585683788 0.276105708273642 no 2457 0.231765230548271 3736 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2353 9059630 146.67 µM -0.735024698827844 0.27545498331443 no 2458 0.231162226086471 3775 4779114 SGTC_1653 st012112 65 µM -0.735797514728175 0.275201054549355 no 2459 0.230926966961754 3733 720429 SGTC_1441 4106-0040 13 µM -0.735854587966969 0.275182306223154 no 2460 0.230909598138849 3722 2904180 SGTC_673 1082-0474 110 µM -0.736817992773067 0.274865926610042 no 2461 0.230616519910099 3752 3098046 SGTC_748 act1.228 77.9 µM -0.736940978243772 0.274825551411193 no 2462 0.230579121357524 3679 4421505 YNR035C ARC35 SGTC_2382 9035899 200 µM -0.737935150528944 0.274499279549677 no 2463 0.230276928771751 3756 6462679 SGTC_810 3825-7150 143 µM -0.738140179579441 0.274432015989019 no 2464 0.23021463488174 3762 22330411 YGL099W LSG1 SGTC_2091 4-phenylthiadiazole 200 µM -0.739195409250962 0.274085957163863 no 2465 0.22989417403341 3741 270010 SGTC_1210 3013-0140 750 nM -0.739688131967248 0.273924444371388 no 2466 0.229744625501194 3772 905973 SGTC_344 k064-0035 6.43 µM -0.742225310308179 0.27309351177065 no 2467 0.228975417998428 3737 5088750 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.744994881797735 0.272187898234714 no 2468 0.228137406998547 3736 688803 SGTC_3098 9119039 49.47 µM -0.74524053425245 0.272107645231163 no 2469 0.228063161361358 3740 17161528 SGTC_1081 sertraline 6 µM -0.746648030823151 0.271648052491955 no 2470 0.227638023745972 3750 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3022 9087993 49.47 µM -0.746796250790183 0.271599676423937 no 2471 0.227593279541707 3771 17173644 SGTC_2019 4016004 108 µM -0.746981167284114 0.271539329349681 no 2472 0.227537464442196 3760 45595336 SGTC_1680 diphenhydramine 100 µM -0.747709505559858 0.271301702791751 no 2473 0.227317698180249 3777 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2402 5553605 200 µM -0.748000027580404 0.271206946435385 no 2474 0.227230070453353 3774 6758546 SGTC_1715 st032160 10.2275 µM -0.749109492610801 0.270845236374832 no 2475 0.226895607020975 3660 5289825 SGTC_263 alizarin 107.927 µM -0.75096799452474 0.270239863757945 no 2476 0.226335958824923 3774 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1284 0929-0043 16 µM -0.75103220149092 0.270218961624026 no 2477 0.226316638210989 3749 1239883 SGTC_2228 7354201 200 µM -0.751503509782732 0.270065555221106 no 2478 0.226174844651331 3771 753451 SGTC_1372 2752-0194 270 µM -0.75175737652872 0.26998294204991 no 2479 0.226098489399822 3727 823334 SGTC_595 3909-8003 73.7 µM -0.752056811311358 0.269885516412669 no 2480 0.226008447423431 3831 699517 SGTC_1757 st041620 31.8375 µM -0.752213296946517 0.269834608446425 no 2481 0.22596139924667 3824 5289815 SGTC_3157 9099274 49.47 µM -0.752306204847232 0.269804385887637 no 2482 0.225933468648743 3723 17217662 SGTC_1179 1021-1431 9.29 µM -0.753289376082822 0.269484668227393 no 2483 0.225638020753284 3777 2840958 SGTC_2007 4011539 71.82 µM -0.754618517567906 0.269052746521007 no 2484 0.225238954811479 3758 45595301 SGTC_387 norethindrone acetate 66.7 µM -0.755378394920025 0.268805970741776 no 2485 0.225010986379428 3771 541197 SGTC_2787 5284540 71.43 µM -0.756030611897499 0.26859424916514 no 2486 0.224815421125179 3811 736958 SGTC_2818 7996756 12.99 µM -0.75688452238895 0.268317180931989 no 2487 0.224559524435854 3763 2241621 SGTC_459 nigericin 15.3 µM -0.7575700325614 0.268094857609454 no 2488 0.224354212959696 3799 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3046 9092212 49.47 µM -0.758354848228555 0.267840441618018 no 2489 0.224119290195612 3784 25236637 SGTC_2460 5552655 174.22 µM -0.759454521899334 0.267484161900239 no 2490 0.223790354579217 3747 5401989 SGTC_2224 6650123 117.647 µM -0.759660545972193 0.26741743941861 no 2491 0.223728758965453 3733 2908370 SGTC_2874 9043904 71.43 µM -0.760288495709685 0.267214124864007 no 2492 0.223541078483827 3758 4463428 SGTC_2721 ifenprodil 61.44 µM -0.760317816183864 0.267204633528247 no 2493 0.223532317422341 3751 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.760522521180218 0.267138373179782 no 2494 0.223471156286646 3724 279621 SGTC_3159 9100096 49.47 µM -0.760535284588344 0.267134242105078 no 2495 0.223467343189731 3739 25236875 SGTC_559 1550-0661 158 µM -0.762174131424159 0.26660407201356 no 2496 0.222978041599328 3820 5830875 SGTC_641 4092-0595 30 µM -0.767626023664172 0.264844211754582 no 2497 0.221354698544472 3834 786260 SGTC_2754 granisetron 64.02 µM -0.774631299265096 0.262591623538444 no 2498 0.219278778492103 3769 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2912 7964298 10.93 µM -0.775660060865144 0.262261646690878 no 2499 0.218974863793805 3852 2975850 SGTC_1778 st046819 58.9 µM -0.777104261360485 0.261798775845639 no 2500 0.218548630020564 3844 671715 SGTC_85 0868-0259 160.055 µM -0.777867063017631 0.261554464723841 no 2501 0.218323693658725 3767 83173 SGTC_1950 st077106 7.18 µM -0.778452744215552 0.261366961435749 no 2502 0.218151077455071 3822 13831864 SGTC_1021 4476-0760 85.3 µM -0.779398833412171 0.261064220998071 no 2503 0.217872405413358 3824 746768 SGTC_898 1000-0849 28.3 µM -0.779916558066661 0.260898629891517 no 2504 0.217719995765554 3746 6751807 SGTC_2074 5212007 75.395 µM -0.781845392673451 0.260282179671085 no 2505 0.217152720237233 3683 758611 SGTC_853 0419-0306 21 µM -0.784156132387855 0.259544662979526 no 2506 0.216474250918771 3816 762713 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.785389248808471 0.259151532378339 no 2507 0.216112691182386 3828 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1871 st057448 67.3 µM -0.785599263342915 0.259084608208015 no 2508 0.216051148091586 3856 691747 SGTC_758 0868-0029 16 µM -0.787399605492652 0.258511270003224 no 2509 0.215523988810449 3877 762687 SGTC_1022 4477-0945 21.3 µM -0.787804575881712 0.258382393445222 no 2510 0.215405512042703 3784 4648966 SGTC_1625 st003711 30.1 µM -0.788872685781179 0.258042641120375 no 2511 0.215093210730281 3832 24207034 YER133W GLC7 SGTC_352 k048-0007 5.11 µM -0.790969308727573 0.257376406141287 no 2512 0.214480950738481 3842 6811911 SGTC_1785 bathophenanthroline 24 µM -0.791160605140459 0.257315663220252 no 2513 0.214425138470127 3757 72812 An iron chelator. SGTC_2032 5185112 25.99 µM -0.792745068626795 0.256812830378936 no 2514 0.213963183271155 3745 5718189 SGTC_2182 6325192 200 µM -0.793194026707121 0.256670445626294 no 2515 0.213832393578577 3737 736248 SGTC_2157 5649910 96.377 µM -0.793784043310167 0.256483387411748 no 2516 0.213660581774688 3791 2858091 SGTC_1040 k898-0338 155 µM -0.794118329086122 0.256377437344645 no 2517 0.213563274041305 3800 20969351 SGTC_2249 haloperidol 116.36 µM -0.794224864090222 0.256343676445154 no 2518 0.21353226803888 3826 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_415 dibenzyl ketone 100 µM -0.797079894896033 0.255439782169588 no 2519 0.212702316012288 3851 7593 SGTC_491 tetrandrine 80.3 µM -0.79877012605421 0.25490544591552 no 2520 0.212211857917876 3816 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3271 9137798 49.47 µM -0.800740639216575 0.254283242828691 no 2521 0.211640905229475 3733 6498326 SGTC_568 1193-0097 7.48 µM -0.800910222283089 0.254229733043817 no 2522 0.211591810894257 3699 3646150 SGTC_2009 4012297 12.05 µM -0.801589658740332 0.254015404721172 no 2523 0.211395180766176 3854 45595307 SGTC_1701 st028638 40.4 µM -0.802108651188669 0.253851752370548 no 2524 0.211245055543784 3799 3490878 SGTC_1907 st060210 83.7 µM -0.806641408681832 0.252424807181124 no 2525 0.209936554759109 3876 688793 SGTC_1055 3448-0672 86 µM -0.80717673873122 0.252256560924176 no 2526 0.209782332653524 3872 748378 SGTC_1727 st034309 9.9045 µM -0.807611694234585 0.252119904442541 no 2527 0.209657076297122 3970 870305 SGTC_170 4197-0004 226 µM -0.808079690809205 0.251972910577812 no 2528 0.20952235406636 3883 218692 SGTC_859 0439-0102 54.6 µM -0.808209655194726 0.251932097861095 no 2529 0.209484950239723 3815 610143 SGTC_180 1486-1293 102.781 µM -0.808840747865883 0.251733965440008 no 2530 0.209303377258005 3789 4140536 SGTC_3252 9135871 49.47 µM -0.809493300083247 0.251529182325183 no 2531 0.209115727546733 3842 17682838 SGTC_2676 harmalol 100 µM -0.810120235263201 0.251332521252804 no 2532 0.208935537679178 3808 5459187 A monoamine oxidase inhibitor SGTC_1244 0416-0015 52.5 µM -0.810540232061738 0.251200819430034 no 2533 0.208814875949361 3838 96201 SGTC_1182 1222-0449 220 µM -0.813201059870494 0.2503672907353 no 2534 0.208051395931154 3855 658318 SGTC_2147 5545932 89.7195 µM -0.813258663200286 0.250349262191718 no 2535 0.208034885862144 3889 797404 SGTC_1716 st033144 30.6155 µM -0.813593508696117 0.250244476729447 no 2536 0.20793892890906 3825 674617 SGTC_1658 st012944 20 µM -0.814669046758039 0.249908058727153 no 2537 0.207630887900152 3760 24207260 SGTC_2794 7785382 27.27 µM -0.81471935231823 0.249892329508356 no 2538 0.207616486668145 3785 2205081 SGTC_1134 3477-0009 42.5 µM -0.815589115548523 0.249620460643691 no 2539 0.207367588395551 3917 3973534 SGTC_2319 6033012 152.6 µM -0.815630137252584 0.249607642041826 no 2540 0.207355853660758 3826 847246 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.816207675647658 0.249427207999491 no 2541 0.207190683774753 3846 6708760 SGTC_1116 jasmonic acid  1.58368 µM -0.816584973802538 0.249309370285096 no 2542 0.207082822520115 3900 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_725 1497-0963 19 µM -0.816620714474743 0.249298209297493 no 2543 0.207072606769758 3887 3549977 SGTC_1948 st076329 66.6 µM -0.819250315010094 0.248477774989311 no 2544 0.206321806740086 3733 24208413 SGTC_603 3794-0023 45.9 µM -0.819321126390442 0.248455701778528 no 2545 0.206301611101939 3837 3802260 SGTC_1098 clofazimine 15.1 µM -0.819607792510795 0.248366353350749 no 2546 0.206219864956313 3936 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2257 7960413 200 µM -0.820367071879847 0.248129783062587 no 2547 0.206003440501231 3848 2974689 YIL048W NEO1 SGTC_622 1348-1566 26.3 µM -0.82071722023817 0.248020727101718 no 2548 0.205903679862504 3915 7340407 SGTC_616 4092-0450 108 µM -0.821104850235496 0.247900027076309 no 2549 0.205793273775263 3895 787165 SGTC_1949 st076024 69.1 µM -0.823731627994634 0.247082929116969 no 2550 0.205046032084673 3816 2921930 SGTC_1304 1165-0502 251 µM -0.824080651834887 0.246974468639106 no 2551 0.204946866499393 3869 767425 SGTC_3176 9106582 49.47 µM -0.824425497472759 0.246867331578841 no 2552 0.204848916044343 3786 17018027 SGTC_1651 st011928 86.1 µM -0.825598088247698 0.246503215841231 no 2553 0.204516059986888 3879 720198 SGTC_537 1334-0398 209 µM -0.826039660929516 0.246366172238074 no 2554 0.204390796966642 3831 5846986 SGTC_1887 st057648 70.8 µM -0.82677183025478 0.246139030986476 no 2555 0.204183199689064 3900 688672 SGTC_1140 3229-1848 2.98 µM -0.82725265692695 0.24598992501122 no 2556 0.2040469357553 3901 2849525 SGTC_1563 conessine 56.1 µM -0.828820488839223 0.245504071872433 no 2557 0.203602996319203 3945 441082 An anti-amoebic, histamine inhibitor. SGTC_1138 3761-0006 1.03 µM -0.829210719516581 0.245383224037306 no 2558 0.203492590143292 3828 12061087 SGTC_328 k915-0120 63.5 µM -0.830606917587759 0.244951107073376 no 2559 0.203097862792261 3873 6624543 SGTC_2507 purpurin 79.67 µM -0.830748897394994 0.244907187914271 no 2560 0.20305774847063 3883 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1241 0364-0022 50.8 µM -0.831428409850789 0.244697050401194 no 2561 0.202865827658525 3906 4563895 SGTC_19 0279-0214 38.434 µM -0.832061017179908 0.24450150547521 no 2562 0.202687252115138 3923 3566274 YBR002C RER2 SGTC_481 bay k-8644 50 µM -0.832217658660626 0.244453099114201 no 2563 0.202643049093069 3855 2303 A calcium channel antagonist. SGTC_593 1203-0218 61.7 µM -0.834537637678672 0.243736769175015 no 2564 0.20198904365486 3912 3666956 SGTC_2453 5731132 22.18 µM -0.835007482532999 0.243591835308795 no 2565 0.201856747713449 3919 1362040 SGTC_162 k030-0015 37.8 µM -0.835102046818533 0.243562670525286 no 2566 0.201830127173133 3946 1809920 YMR134W ERG29 SGTC_2649 anisomycin 9.56 µM -0.835130206973366 0.243553985953178 no 2567 0.201822200289106 3871 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3168 9103419 49.47 µM -0.836243080019455 0.243210910628612 no 2568 0.201509083688105 3835 16649256 SGTC_3080 9117754 49.47 µM -0.83701258747369 0.242973840550855 no 2569 0.201292746329721 3894 9550191 SGTC_1185 1319-0113 81.3 µM -0.839178429408227 0.242307258931974 no 2570 0.200684594958291 3952 4672763 SGTC_376 3970-0862 59.1 µM -0.839532689590866 0.242198322587053 no 2571 0.200585226552893 3914 3135186 SGTC_1264 0783-0040 158 µM -0.839600072906495 0.242177604968435 no 2572 0.200566329177258 3801 2855798 SGTC_1702 st027038 51 µM -0.839906556042473 0.242083386039899 no 2573 0.200480390723709 3926 5521182 SGTC_1527 coumarin 137 µM -0.841563047959631 0.241574492136139 no 2574 0.200016290154889 4011 323 A hepatotoxic, DNA x-linker. SGTC_1946 st076057 65.1 µM -0.8426515577052 0.241240405596589 no 2575 0.199711673556455 3767 953009 SGTC_1370 2001-0092 44.6 µM -0.843004579231076 0.241132109812238 no 2576 0.199612941377256 3944 790957 SGTC_713 1488-1073 324 µM -0.843447809932001 0.240996178150648 no 2577 0.19948902131966 3837 3312542 SGTC_2347 9049783 174.81 µM -0.84476921999992 0.240591170564446 no 2578 0.199119851581954 3934 6467988 YPL169C MEX67 SGTC_458 nppb 133 µM -0.845546353556578 0.240353154990127 no 2579 0.198902931751468 3891 4549 A chloride channel blocker. SGTC_2996 9066192 71.4286 µM -0.845774909239119 0.240283178812581 no 2580 0.198839162547184 3968 6472854 SGTC_2251 lansoprazole 556 µM -0.846600698470293 0.240030442043126 no 2581 0.198608862242014 3813 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_192 3455-0609 60.9 µM -0.847914448391085 0.239628661450654 no 2582 0.198242808700667 3963 3769639 SGTC_1273 0849-0096 14.1 µM -0.849113418107002 0.239262304386603 no 2583 0.197909092344384 3922 5286025 SGTC_283 0987-0079 11.7 µM -0.850829208133116 0.238738560498802 no 2584 0.197432117035433 3920 411556 SGTC_1031 k035-0009 16 µM -0.851565905497753 0.23851387668748 no 2585 0.197227534805581 3985 5180959 SGTC_1443 4112-3303 14 µM -0.852627051207708 0.238190443600902 no 2586 0.196933078179737 3921 704433 SGTC_1603 st002045 67.8 µM -0.853028855204646 0.238068038055859 no 2587 0.196821651353783 3908 5887985 SGTC_293 4049-0273 38.5 µM -0.853978325206312 0.237778928610076 no 2588 0.196558499513968 3792 1380311 SGTC_2010 4012422 159 µM -0.854595502729732 0.237591104085774 no 2589 0.196387559089713 3907 952393 SGTC_1389 3405-0187 19 µM -0.858064484775094 0.236536911438238 no 2590 0.195428428464726 3887 799890 SGTC_968 1309-0633 340 µM -0.858925785809154 0.236275569189419 no 2591 0.195190731029016 3950 3761976 SGTC_318 1488-0629 67.2 µM -0.859024940621261 0.236245493121677 no 2592 0.195163378075387 3967 3662576 SGTC_2386 9075165 157.42 µM -0.859261007179196 0.236173896874979 no 2593 0.195098265875638 3876 16452277 SGTC_1215 3852-0577 11.2 µM -0.859284129651408 0.236166884740267 no 2594 0.19509188891394 3981 2884876 SGTC_504 lovastatin 124 µM -0.859881745698626 0.235985691131015 no 2595 0.194927115952387 3940 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.860654047668549 0.235751647310439 no 2596 0.194714304481704 3916 6857784 SGTC_2681 menadione 3.18 µM -0.860700207931245 0.235737662634628 no 2597 0.194701589280527 3938 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_839 0122-0028 230 µM -0.861608172812242 0.235462679342941 no 2598 0.194451586037807 3903 759448 SGTC_444 curcumin 90.4 µM -0.861944892527969 0.235360746516006 no 2599 0.194358921768892 3882 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1496 4469-0713 57.4 µM -0.861956462462878 0.235357244462659 no 2600 0.194355738234903 3872 746691 SGTC_3036 9090181 49.47 µM -0.863410232219285 0.234917438147077 no 2601 0.193955977798346 3943 25236586 SGTC_1158 4092-0494 91.8 µM -0.864065784399573 0.234719263814175 no 2602 0.193775876818528 4015 1148199 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.864210912276454 0.234675403955694 no 2603 0.193736019374566 3918 75037 A free radical scavenger. SGTC_3311 9131146 2.8755 µM -0.865367894143347 0.23432590851105 no 2604 0.193418448458421 3906 4900406 YPR165W RHO1 SGTC_383 2324-0395 7.37 µM -0.865621791846865 0.234249250893276 no 2605 0.193348800579363 3945 3146421 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.865828943713266 0.234186717215405 no 2606 0.193291987109759 3961 5357218 A potent inhibitor of glutathione S-transferases. SGTC_156 3474-0145 5.642 µM -0.867255867748091 0.233756217735869 no 2607 0.192900915785992 3792 2265471 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.868316494556615 0.233436513635563 no 2608 0.192610547413096 3915 688761 SGTC_1075 aripiprazole 15.2 µM -0.872489980369108 0.232180860397831 no 2609 0.191470565945411 3959 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3081 9117243 49.47 µM -0.872813599042579 0.232083652351205 no 2610 0.19138234302643 3956 45595589 SGTC_2482 5981709 142.65 µM -0.87442083667589 0.231601208766376 no 2611 0.190944557051905 3916 877755 SGTC_2158 5657123 3.6195 µM -0.875512564130403 0.23127382462334 no 2612 0.190647538490513 3866 2858827 SGTC_2563 tomatine 8.54 µM -0.875758824554303 0.231200012442859 no 2613 0.190580579380061 3832 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_916 4466-0038 42 nM -0.877448443905735 0.230693933714302 no 2614 0.190121555139573 4018 5722064 YGL116W CDC20 SGTC_1000 4048-0884 8.67 µM -0.879139893180641 0.230187927348519 no 2615 0.189662714887017 3976 13040088 SGTC_2412 st077135 33.4 µM -0.879442883318973 0.230097351791416 no 2616 0.189580594602941 4048 13258915 SGTC_2879 9041815 71.43 µM -0.879587890020667 0.230054010695062 no 2617 0.189541300762735 3950 4942971 SGTC_2930 9013230 14.89 µM -0.88070325663424 0.22972079118171 no 2618 0.189239226838018 3979 2995857 SGTC_2476 5806916 10.51 µM -0.882811855950398 0.229091579221624 no 2619 0.188668966832779 3835 2870194 SGTC_551 k048-0028 34.9 µM -0.884253661723693 0.228661897434724 no 2620 0.188279648246608 3945 6836383 SGTC_213 1246-0773 967 nM -0.886286352202863 0.228056891786468 no 2621 0.187731620734282 3934 6251622 SGTC_419 nsc-638432 893 µM -0.887381301374526 0.227731366908464 no 2622 0.187436823564276 3927 368090 SGTC_837 0091-0265 12.5 µM -0.888440818363945 0.227416625035508 no 2623 0.18715183847953 3911 759367 SGTC_2465 5809242 33.21 µM -0.888900250241787 0.227280221642137 no 2624 0.18702834547837 3967 2731748 SGTC_289 k017-0060 526 µM -0.889059801668793 0.227232862281627 no 2625 0.186985470644963 3924 5512909 SGTC_2294 7971431 200 µM -0.889724276106066 0.227035687363426 no 2626 0.186806977754367 3962 5741572 SGTC_2067 5224629 34.075 µM -0.890236644403836 0.226883714036809 no 2627 0.186669416053129 3961 2835000 SGTC_912 3474-0017 2.18 µM -0.892530526210854 0.226204030762965 no 2628 0.186054319134057 4014 3360550 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.893207064605966 0.226003790551709 no 2629 0.185873147774451 3776 6708630 An antioxidant. SGTC_2363 9053361 176 µM -0.895270948530244 0.225393546662156 no 2630 0.185321133106892 4035 6469797 YMR079W SEC14 SGTC_1744 st037937 38.9 µM -0.896603174382288 0.225000133510528 no 2631 0.184965351798978 4046 1016152 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.897007638070068 0.224880770356299 no 2632 0.184857420655978 4029 165506 SGTC_820 1582-0060 59.9 µM -0.897893430503421 0.22461948547893 no 2633 0.184621183693641 3996 3848840 SGTC_2409 alverine citrate 63.97 µM -0.898437195753287 0.224459174739529 no 2634 0.184476256916838 4157 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_281 1672-3440 14.9 µM -0.898460733475607 0.224452236906908 no 2635 0.184469985134774 4015 6833000 SGTC_1738 st035555 74 µM -0.90013970911366 0.223957666534745 no 2636 0.184022953149491 4041 5331140 SGTC_591 4299-0174 154 µM -0.901361270052997 0.223598224793726 no 2637 0.183698133367618 3955 5509088 SGTC_1190 1486-1332 13 µM -0.90165299684555 0.223512433353305 no 2638 0.183620614478854 3970 4150046 SGTC_1760 st045453 10.4495 µM -0.901986839399604 0.223414279425977 no 2639 0.183531929425227 4023 3323419 YIL048W NEO1 SGTC_590 k048-0076 22.4 µM -0.90254317241817 0.223250764991443 no 2640 0.183384199250931 3992 6832814 SGTC_1988 st071872 53.4 µM -0.902775514352603 0.223182496458403 no 2641 0.183322524497582 3993 16414116 SGTC_2965 9082772 38.63 µM -0.903333940384834 0.223018463950471 no 2642 0.183174344206737 3992 16459634 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.90337832655634 0.223005428867324 no 2643 0.18316256938756 3929 16623 A steroid. SGTC_904 1141-0088 396 µM -0.904590845499449 0.222649510941262 no 2644 0.182841093469611 3991 1378119 SGTC_2627 acetyl isogambogic acid 100 µM -0.904974678451543 0.222536909674983 no 2645 0.182739401028001 4004 6857789 A caspase activator and apoptosis inducer. SGTC_394 menadione 8.33 µM -0.905761713498074 0.222306126587163 no 2646 0.182530994953812 3970 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1641 st009299 47.1 µM -0.906634781786097 0.222050275707339 no 2647 0.182299981117974 3890 4046054 SGTC_1919 st067113 52.3 µM -0.907162230585322 0.221895789401293 no 2648 0.182160506754215 4025 1268243 SGTC_2650 prasterone 100 µM -0.908489769971459 0.221507233575327 no 2649 0.181809758110356 3948 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1368 1852-0141 284 µM -0.908631341513499 0.221465820142002 no 2650 0.181772378495006 3991 2838987 SGTC_801 0866-0028 10.1 µM -0.909102814891222 0.221327933587923 no 2651 0.181647928446348 3962 6849771 SGTC_2277 7947813 106.88 µM -0.910157073546819 0.221019784031999 no 2652 0.181369839435909 4068 1246798 SGTC_778 3456-2434 196 µM -0.910301863394074 0.220977482552406 no 2653 0.181331668057217 3979 5539063 SGTC_2001 4023502 57.655 µM -0.911245582313866 0.220701881293336 no 2654 0.181082995887705 4007 108941 YCR052W RSC6 SGTC_765 1319-0117 244 µM -0.911872813076195 0.220518815387427 no 2655 0.18091783734235 3944 3487746 YGL099W LSG1 SGTC_2040 5100729 123 µM -0.913089350709259 0.220164000339589 no 2656 0.180597775353773 3992 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2335 9018011 154.17 µM -0.913163738890915 0.22014231492974 no 2657 0.18057821590459 4008 6458208 SGTC_2050 5263056 171 µM -0.913920018473823 0.219921916223506 no 2658 0.180379436993556 4012 763468 YGL055W OLE1 SGTC_3300 9124615 50.48 µM -0.914525390102774 0.219745587135332 no 2659 0.180220421376171 4040 24824903 SGTC_746 1095-0025 46.6 µM -0.915759467454643 0.219386383830318 no 2660 0.17989653346254 4017 6749286 SGTC_1677 st019204 53.9 µM -0.916115112263299 0.219282928837432 no 2661 0.179803261140272 4012 3945625 SGTC_2729 fluphenazine 10.66 µM -0.918239411369202 0.218665566890584 no 2662 0.179246769823907 3930 3372 An atypical antipsychotic. SGTC_1691 st019933 84.6 µM -0.918512982482014 0.218586134674851 no 2663 0.17917518266986 3942 6176082 SGTC_2585 alliin 100 µM -0.919332495254266 0.218348286057648 no 2664 0.178960843011381 4055 87310 A garlic compound which reacts with lipids. SGTC_531 3788-1495 174 µM -0.919890019586311 0.218186560050107 no 2665 0.178815117443667 3951 2896655 SGTC_2139 5578692 56.4705 µM -0.920172886546878 0.218104532735956 no 2666 0.178741210320538 3945 650991 YMR113W FOL3 SGTC_1994 st072947 40.9 µM -0.921619163266711 0.217685411346202 no 2667 0.178363629566876 4057 5286565 YDL195W SEC31 SGTC_2282 7944268 200 µM -0.921844089405651 0.217620271025236 no 2668 0.178304953087885 4021 2970414 SGTC_2106 5357045 167.29 µM -0.922650985981351 0.217386680215854 no 2669 0.178094558090599 4029 668842 SGTC_2184 6075246 200 µM -0.925029308119152 0.216699015722233 no 2670 0.17747533125682 4030 2267320 SGTC_3072 9116419 49.47 µM -0.92671412869005 0.216212631457594 no 2671 0.177037489928146 4037 17170162 SGTC_2417 cerulenin 830 nM -0.927311935828301 0.216040204903411 no 2672 0.176882299477835 4039 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_193 1273-0060 1.558 µM -0.927956269529561 0.215854447835397 no 2673 0.176715127061709 3813 2847393 YHR072W ERG7 SGTC_360 0957-0399 1.01 µM -0.928752223415757 0.21562510753196 no 2674 0.176508754742567 4030 6752301 YPR165W RHO1 SGTC_1300 1094-0077 113 µM -0.930273482168445 0.215187176504814 no 2675 0.176114752035569 3966 5532636 SGTC_391 gliotoxin 8.33 µM -0.930341276146925 0.215167672396493 no 2676 0.176097206510511 4103 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2122 5258151 111.688 µM -0.932451855028568 0.214560979124841 no 2677 0.175551528432396 4006 2173356 SGTC_2338 7999974 200 µM -0.932829844446619 0.214452429836823 no 2678 0.175453914699505 4027 315925 SGTC_1500 4488-1866 171 µM -0.934387218190103 0.214005527251085 no 2679 0.175052094311507 4077 2900003 SGTC_769 0302-0231 76 µM -0.934487920447845 0.213976648492541 no 2680 0.175026132078608 3952 571869 YER009W NTF2 SGTC_1183 1254-0324 198 µM -0.9351793210308 0.213778434257679 no 2681 0.174847946802549 4090 5799357 SGTC_1240 0356-0016 42.1 µM -0.937133581373624 0.213218755594641 no 2682 0.174344924727394 3995 4305613 SGTC_2788 5282734 71.43 µM -0.937266216079613 0.213180801464275 no 2683 0.174310818212468 4115 743706 SGTC_1619 st003326 88.7 µM -0.938293689914035 0.212886917851093 no 2684 0.174046750826057 4008 2849032 SGTC_988 1497-1057 103 µM -0.939410248162698 0.212567822079829 no 2685 0.173760076679912 3939 3533044 SGTC_1079 idarubicin 2.36 µM -0.94084371617063 0.212158568019357 no 2686 0.173392477171506 4029 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1650 st011916 45.8 µM -0.941457011883829 0.211983613343448 no 2687 0.173235354525674 3928 242528 SGTC_2723 salbutamol 83.58 µM -0.942002946588073 0.211827945734475 no 2688 0.173095565661979 4040 9884233 β2-adrenoceptor agonist SGTC_2896 9052656 71.43 µM -0.942159508175019 0.211783316168124 no 2689 0.173055490673678 3896 6469436 SGTC_262 fenpropimorph 62.5 µM -0.944184894016912 0.211206454301822 no 2690 0.172537586595393 3985 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_319 1348-1596 45.5 µM -0.944303332818818 0.21117274957883 no 2691 0.172507331658282 4136 5380505 SGTC_288 1315-0019 35.1 µM -0.944664873829839 0.211069883539949 no 2692 0.172414997713705 4094 6811474 SGTC_3014 9081533 49.47 µM -0.947470148674002 0.210272722323829 no 2693 0.171699630239022 4072 21367265 SGTC_2088 5278280 127.392 µM -0.949148507756009 0.209796637721199 no 2694 0.17127254311832 4088 791502 SGTC_2107 5363541 170.161 µM -0.952386575532499 0.208879917700583 no 2695 0.17045048258708 4008 244052 SGTC_1751 st044839 27.194 µM -0.953340085677754 0.208610422638537 no 2696 0.170208893749022 4015 5291326 SGTC_2165 5727197 32.143 µM -0.955152148354727 0.208098836103406 no 2697 0.169750380263013 4219 1361712 SGTC_2587 piperic acid 92.2 µM -0.955900331608278 0.207887823114207 no 2698 0.169561295724936 4039 5370536 SGTC_2841 9004761 38.96 µM -0.956088151421713 0.207834871419515 no 2699 0.169513850208238 4041 2991039 SGTC_2317 5986382 200 µM -0.956709115543325 0.207659860856801 no 2700 0.169357047936264 4068 877883 SGTC_2393 9031399 185.94 µM -0.957949874795118 0.207310430104173 no 2701 0.169044017523459 4101 1526623 YDL150W RPC53 SGTC_2285 7945142 200 µM -0.959705076004512 0.206816713072249 no 2702 0.168601833927543 4099 2970608 SGTC_2216 7189485 200 µM -0.963449421395354 0.205765802765112 no 2703 0.167661017436884 4047 731273 SGTC_2159 5658611 73.75 µM -0.963521445315553 0.205745619214506 no 2704 0.167642953677891 4030 793844 SGTC_2611 pyromycin 23.93 µM -0.964449961131847 0.205485522741649 no 2705 0.16741019209946 4033 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.967655539079589 0.204589075846976 no 2706 0.166608214914138 4071 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_759 3486-0358 89.3 µM -0.968002493679102 0.204492188989306 no 2707 0.16652156215151 4043 875103 SGTC_45 0kpi-0036 14.9 µM -0.968010907943194 0.204489839650451 no 2708 0.166519461029795 4081 2795021 SGTC_1112 tnp00069 1.16933 µM -0.968106505125915 0.204463149177933 no 2709 0.166495590706427 4063 145826 SGTC_3343 9148379 18.9835 µM -0.972330173173461 0.203285983285642 no 2710 0.165443158822147 4100 1955036 SGTC_674 0498-0004 451 µM -0.974179738181642 0.202771772521623 no 2711 0.164983651620433 4050 4231473 SGTC_2612 dictamnine 15.46 µM -0.975119032073772 0.202510930544465 no 2712 0.164750609510306 4030 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_330 1488-0319 80.1 µM -0.975994813344873 0.20226790683057 no 2713 0.164533517303431 4105 6846614 SGTC_216 k038-0035 28.382 µM -0.977062140388703 0.201971966360659 no 2714 0.164269194725416 3996 4444231 YPR107C YTH1 SGTC_1587 estradiol valerate 56.1 µM -0.977964261137253 0.20172203527905 no 2715 0.164046000174862 4114 13791 A steroid. SGTC_3286 9117135 37.221 µM -0.981741349029315 0.200677612231101 no 2716 0.163113644585055 4035 3438150 SGTC_1825 st052143 62.6 µM -0.984290496507312 0.199974571954815 no 2717 0.16248635043757 4117 674173 SGTC_743 1275-0778 158 µM -0.988251614466813 0.198885061419905 no 2718 0.161514717857522 4064 2849257 YMR203W TOM40 SGTC_235 0330-0087 5 mM -0.989197847286352 0.198625329274239 no 2719 0.161283175733671 4105 46494818 YHR062C RPP1 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.989999656248151 0.198405400336091 no 2720 0.16108714352048 4145 1273210 SGTC_1107 amlodipine 47 µM -0.991056767301341 0.198115669015351 no 2721 0.16082893087787 3812 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2761 levamisole 97.89 µM -0.993412481164259 0.197470938293718 no 2722 0.160254490807626 4047 26879 An alkaline phosphatase inhibitor. SGTC_3160 9100216 49.47 µM -0.994344775406777 0.197216131297355 no 2723 0.160027522004201 4007 17191039 SGTC_236 1509-0011 5.31 µM -0.996136393248438 0.196727019815945 no 2724 0.159591939655702 4133 3107280 SGTC_1555 citronellol 128 µM -0.99797299507715 0.196226391045673 no 2725 0.159146226879383 4050 8842 A terpine precursor. SGTC_93 0109-0045 59.227 µM -0.998854219804132 0.195986457530945 no 2726 0.158932658026623 4191 88733 SGTC_1236 0330-0013 258 µM -0.998872995568685 0.195981347338346 no 2727 0.158928109678432 4101 4617066 SGTC_2683 piperine 63.03 µM -0.999134973884632 0.195910053233974 no 2728 0.158864655457048 4070 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_736 0958-0254 92.6 µM -0.999396512642761 0.195838894448853 no 2729 0.158801324267028 4185 6812352 SGTC_2302 7771753 200 µM -0.999866760801962 0.195710990013327 no 2730 0.158687496064556 4090 2203047 SGTC_1491 4138-0063 26.5 µM -1.00091236446987 0.195426774411611 no 2731 0.158434589148939 4053 23883227 SGTC_1085 doxorubicin 7.67 µM -1.00134799258601 0.195308436159548 no 2732 0.158329299029276 4118 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_553 k007-0256 45.7 µM -1.0035094068231 0.194721932763921 no 2733 0.157807570264791 4140 6287000 SGTC_976 1348-1067 47.6 µM -1.00401039886461 0.194586140843155 no 2734 0.157686800651128 4105 5310671 YGL099W LSG1 SGTC_2458 5808907 16.39 µM -1.0040449909461 0.194576766922938 no 2735 0.157678464092822 4244 2731747 SGTC_670 4204-0025 119 µM -1.0048407768316 0.194361197114318 no 2736 0.15748676270777 4096 719039 SGTC_807 1315-0151 48 µM -1.00510462314966 0.194289756103698 no 2737 0.157423237092918 4133 4011080 SGTC_2186 6124449 200 µM -1.00754498547931 0.193629743450748 no 2738 0.156836475573528 4100 3834182 YLR033W RSC58 SGTC_2884 9058502 51.95 µM -1.00781301022705 0.193557337751228 no 2739 0.156772119436175 4145 6471554 SGTC_686 1319-0111 510 µM -1.00970208754698 0.193047480377482 no 2740 0.156319021013025 4153 4562600 SGTC_3340 9146634 11.102 µM -1.00974646693312 0.193035512356445 no 2741 0.156308386921795 4120 4907387 SGTC_2765 myclobutanil 7.74 µM -1.01181196660263 0.192478999601513 no 2742 0.155813983609891 4130 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_945 3381-0768 11.3 µM -1.01187417783296 0.192462253104341 no 2743 0.155799108582382 4145 1126236 YIL048W NEO1 SGTC_821 1114-0266 29.2 µM -1.01189937682752 0.192455470098783 no 2744 0.155793083638668 4133 3123235 SGTC_1481 3346-2004 36 µM -1.01254031468016 0.192282993108169 no 2745 0.155639890501828 4155 2770522 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.01389658418184 0.19191833150343 no 2746 0.155316050733262 4240 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_295 k015-0027 31 µM -1.01483755264777 0.19166558122731 no 2747 0.155091634879457 4134 3887424 SGTC_1396 3511-0007 98.6 µM -1.01502862965824 0.191614281606876 no 2748 0.15504609021777 4112 X1396 SGTC_2219 9098279 200 µM -1.01534639283313 0.191528988397262 no 2749 0.154970368501075 4041 902349 SGTC_943 3253-1379 105 µM -1.01617761523172 0.191305983750377 no 2750 0.15477240698867 4134 668464 SGTC_1711 st032263 62.8 µM -1.01722784524499 0.191024450284604 no 2751 0.154522526257945 4110 3958979 SGTC_3226 9131256 49.47 µM -1.01992310562844 0.190303099845088 no 2752 0.153882465200234 4051 17178073 SGTC_181 1447-1644 8.07 µM -1.02038859056141 0.190178688678281 no 2753 0.153772101396127 4117 534600 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.02195115005037 0.189761425587063 no 2754 0.153402010747115 3938 88881 An O-methylated flavonoid and antioxidant. SGTC_2769 toremifene 3.73 µM -1.02272636206198 0.189554623471864 no 2755 0.153218621714594 4157 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2258 7960471 200 µM -1.02555133691388 0.188802183336144 no 2756 0.152551557688078 4158 2974708 SGTC_1345 1488-0192 31.4 µM -1.02679141107252 0.188472468190031 no 2757 0.152259347288892 4177 658348 SGTC_373 0844-0104 25.9 µM -1.02791767920082 0.188173320093488 no 2758 0.151994276294367 4138 5375804 SGTC_314 1671-0008 2.74 µM -1.0279800442958 0.188156763865706 no 2759 0.151979607421172 3994 3913060 SGTC_1895 st058434 18.3 µM -1.02923204026227 0.187824583358541 no 2760 0.151685324799007 4142 5393175 SGTC_2656 pseudo-anisatin 100 µM -1.02945662596973 0.187765034443643 no 2761 0.151632575842326 4150 6708809 A neurotoxin. SGTC_366 0181-0206 4.31 µM -1.03054674600266 0.187476154747728 no 2762 0.151376710109853 4145 274874 SGTC_1321 1326-2144 215 µM -1.03084197251895 0.18739796758565 no 2763 0.151307465940156 4133 3513030 SGTC_1930 st074634 34.3 µM -1.03144847093909 0.187237407083776 no 2764 0.151165280324415 4033 684253 YOR116C RPO31 SGTC_1970 st070122 35.8 µM -1.03211283800254 0.187061624466416 no 2765 0.151009630213163 4156 102928 SGTC_53 0973-0023 39.979 µM -1.03379761063606 0.186616314094586 no 2766 0.150615394445632 3983 674768 SGTC_649 1123-0311 367 µM -1.03719202468433 0.1857211156526 no 2767 0.149823187085955 4027 693629 YIL048W NEO1 SGTC_3139 9095020 49.47 µM -1.0373880510497 0.185669499712326 no 2768 0.149777522397261 3819 25236292 SGTC_2858 9025781 8.96 µM -1.03742141580586 0.185660715284301 no 2769 0.149769750942968 4043 4894980 YPL153C RAD53 SGTC_3287 9117173 37.0625 µM -1.0385493047669 0.18536391114903 no 2770 0.149507196711902 4126 2789709 SGTC_381 3461-2219 42.7 µM -1.03885447011609 0.185283657505714 no 2771 0.149436212007717 4135 2883159 SGTC_1373 2887-0003 58.5 µM -1.03895413098012 0.18525745295452 no 2772 0.149413034705279 4096 776948 SGTC_706 4262-0057 46.9 µM -1.04098376386042 0.184724287695016 no 2773 0.14894154183362 4130 883298 SGTC_1084 voriconazole 435 nM -1.04169243965567 0.18453835021419 no 2774 0.148777147650588 4140 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2948 9070189 9.45 µM -1.04216359432748 0.184414796333526 no 2775 0.148667919272553 4086 6473636 YDL196W YDL196W SGTC_1194 1488-0194 225 µM -1.04247423571339 0.184333363027467 no 2776 0.148595932221691 4077 1391452 SGTC_2429 5902844 64.44 µM -1.04378107216639 0.183991026564581 no 2777 0.14829334535585 4152 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1009 4106-0057 9.87 µM -1.04417212042889 0.183888665284185 no 2778 0.148202881635842 4143 2928005 SGTC_995 3931-2021 34.6 µM -1.04666936605614 0.183235819877191 no 2779 0.147626048587631 4142 730143 SGTC_1434 4073-0095 163 µM -1.04723962458645 0.183086942334982 no 2780 0.147494537070516 4078 24133745 SGTC_1059 3448-6867 171 µM -1.04972518928776 0.182438916959365 no 2781 0.146922239565268 4080 3934407 SGTC_1877 wortmannin 25 µM -1.05077921334241 0.182164549667439 no 2782 0.146680002421451 4142 312145 A covalent inhibitor of PI 3-kinase. SGTC_2281 7943571 200 µM -1.05213719504646 0.181811441229651 no 2783 0.146368304620217 4264 1244024 SGTC_2058 5236698 133 µM -1.05412165112894 0.181296204725089 no 2784 0.145913612361563 4129 766665 SGTC_1784 st039334 36.3 µM -1.05483774035631 0.181110506808265 no 2785 0.145749770364113 4210 3496984 SGTC_2102 5377816 72.7585 µM -1.05571617925036 0.180882870804041 no 2786 0.145548951548322 4185 1379702 SGTC_1679 SEC14.276 6.7 µM -1.05652481729535 0.180673481370647 no 2787 0.145364254367588 4141 1005053 YMR079W SEC14 SGTC_161 4065-0411 162.148 µM -1.0584744360839 0.180169270664063 no 2788 0.144919599725928 4156 1906281 YLR208W SEC13 SGTC_896 0964-0007 44.5 µM -1.06457587648397 0.178597029875374 no 2789 0.143533950604898 4114 6756758 SGTC_2924 9010168 62.78 µM -1.0652951773803 0.178412248905249 no 2790 0.143371187240407 4242 2993929 SGTC_572 0960-0087 17.7 µM -1.06575637231189 0.178293836084556 no 2791 0.143266893673821 4131 6796365 SGTC_2140 5586273 200 µM -1.06593094156834 0.178249027964891 no 2792 0.143227430352574 4121 854421 SGTC_2795 7780010 54.55 µM -1.06710203246457 0.177948618004978 no 2793 0.142962882077412 4138 953673 SGTC_3215 9129942 49.47 µM -1.06801412620044 0.177714867680241 no 2794 0.142757069875742 4151 17682944 SGTC_2887 9044784 58.44 µM -1.06856431041239 0.177573960825212 no 2795 0.142633018761217 4141 6465546 SGTC_2876 9059903 25.97 µM -1.06998426489378 0.177210624331013 no 2796 0.142313195727738 4147 6916095 SGTC_1296 1068-0102 11.9 µM -1.07179168506055 0.176748823243167 no 2797 0.141906804323686 4173 767053 SGTC_2859 9028643 45.46 µM -1.07418872802006 0.176137546543675 no 2798 0.141369051688876 4030 17151580 SGTC_716 1683-5115 658 µM -1.07425181797153 0.176121475891779 no 2799 0.141354916768212 4104 723597 SGTC_773 4358-1457 44.6 µM -1.07529874222285 0.175854932554455 no 2800 0.141120499580254 4175 1186886 SGTC_2250 alverine citrate 130 µM -1.07566419383156 0.175761950013084 no 2801 0.14103873328285 4050 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1939 st074455 53.6 µM -1.07583187476164 0.175719297063488 no 2802 0.141001227036134 4181 1644229 SGTC_776 4476-4378 112 µM -1.07696715607873 0.175430688404815 no 2803 0.140747469488931 4222 2892008 SGTC_1386 3228-0095 33.8 µM -1.07712454838447 0.175390700218018 no 2804 0.140712313709229 4187 870181 SGTC_3312 9133330 71.43 µM -1.07795240609899 0.175180464057555 no 2805 0.140527498180855 4206 17617324 SGTC_1927 st060202 13.8 µM -1.08100106570351 0.174407629530544 no 2806 0.13984831979048 4046 688887 SGTC_587 k089-0003 57 µM -1.08107150599774 0.1743897985696 no 2807 0.139832653564216 4046 9659696 SGTC_2080 5212524 12.4 µM -1.08162194265192 0.174250503226568 no 2808 0.139710275152487 4078 260183 SGTC_1250 0485-0349 40.2 µM -1.08185459060084 0.174191649820488 no 2809 0.139658572504914 4188 6842794 YDL195W SEC31 SGTC_669 0108-0021 26.2 µM -1.08321149822482 0.173848642005172 no 2810 0.139357278614753 4076 17201 SGTC_2037 5169046 200 µM -1.08368442296257 0.173729194072956 no 2811 0.139252372271219 4237 5718022 SGTC_450 aminopyrene 156 nM -1.08424870406204 0.173586740334879 no 2812 0.139127271166971 4106 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3298 9116858 71.43 µM -1.08564779477021 0.173233858189993 no 2813 0.138817422830767 4244 2506942 SGTC_2404 5161160 200 µM -1.08981759751144 0.172184852016283 no 2814 0.137896750313728 4128 2831543 SGTC_1004 4084-0029 199 µM -1.09235925975995 0.171547433369301 no 2815 0.137337611306758 4212 716894 YLR208W SEC13 SGTC_1714 st033236 13.627 µM -1.09347954049166 0.171266959672393 no 2816 0.137091653585693 4230 2916566 SGTC_1753 st043925 64 µM -1.09349272086339 0.171263661577971 no 2817 0.137088761626365 4229 670181 SGTC_834 0312-0008 75.7 µM -1.0939555019629 0.171147886660145 no 2818 0.13698724735353 4180 6385573 YIL048W NEO1 SGTC_3329 9141233 27.5565 µM -1.09563053252448 0.170729259300467 no 2819 0.136620247186009 4153 4909101 YNL103W MET4 SGTC_153 4077-0274 519.67 µM -1.09583285203709 0.170678739556961 no 2820 0.136575964414795 4209 3121976 SGTC_2109 5483026 200 µM -1.09756207769031 0.170247337590543 no 2821 0.136197879877092 4197 759335 SGTC_2480 5767542 37.17 µM -1.10124214099333 0.169331574177225 no 2822 0.135395642682125 4139 2867358 SGTC_1490 4089-0339 670 nM -1.10520001206166 0.168350215519652 no 2823 0.134536465825594 4165 742542 SGTC_1811 st050069 61.5 µM -1.10595758156861 0.168162793204341 no 2824 0.1343724398955 4169 3877702 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.11000805416403 0.167162987146931 no 2825 0.133497777915127 4221 115019 SGTC_1041 0206-0046 107 µM -1.11123795148613 0.166860163153862 no 2826 0.133232969733433 4204 50494 SGTC_3197 9113331 49.47 µM -1.11209783242107 0.166648654527077 no 2827 0.133048044304868 4227 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_398 bronopol 33.3 µM -1.1136324776508 0.166271601368172 no 2828 0.132718443718798 4134 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2846 9008642 19.48 µM -1.11372411402528 0.166249104304296 no 2829 0.132698780494823 4256 2992898 SGTC_80 0159-0065 512.242 µM -1.11543073409692 0.165830482142393 no 2830 0.132332942643412 4105 1548079 SGTC_1499 4480-0877 67.3 µM -1.11582091885166 0.165734868291624 no 2831 0.132249398819366 4157 2861909 SGTC_2323 6148992 148.28 µM -1.11590359588881 0.165714613056603 no 2832 0.132231701218658 4182 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_29 0299-0004 12.984 µM -1.11686935355901 0.165478128444754 no 2833 0.132025094920786 4100 16871 A napthoquinone isolated from Swertia calycina. SGTC_396 dithiazanine 1.25 µM -1.12089146851868 0.164495584252329 no 2834 0.131167031424179 4205 10578 An antihelmenthic. SGTC_3239 9133757 49.47 µM -1.1209416624034 0.164483346553229 no 2835 0.131156347633593 4239 17036923 SGTC_2770 toltrazuril 17.5 µM -1.12199326976747 0.16422709136612 no 2836 0.130932650750384 4158 68591 Kills coccidiodes. SGTC_2598 perillyl alcohol 100 µM -1.12222421936766 0.164170848367355 no 2837 0.130883558707821 4254 10819 An apoptosis inducer. SGTC_774 k060-0086 136 µM -1.12423565548908 0.163681532975432 no 2838 0.130456533520181 4231 5911235 SGTC_1211 1056-0033 32.3 µM -1.12438721451107 0.163644702111924 no 2839 0.130424396825982 4265 6741922 SGTC_2692 st077426 47.7 µM -1.12562311449497 0.16334456278926 no 2840 0.130162539999864 4241 25238571 SGTC_1975 st070967 30.8 µM -1.12626941293344 0.163187751176193 no 2841 0.130025750211872 4210 261391 SGTC_1113 artemisinin 1.17947 µM -1.12761269454211 0.162862143362937 no 2842 0.129741761560157 4251 2240 An anti-malaria and mitochondrial poison. SGTC_1431 4049-0260 9.09 µM -1.13109074018741 0.162021038979942 no 2843 0.129008450649596 4221 3854841 SGTC_2602 kawain 100 µM -1.13111155487334 0.162016013845012 no 2844 0.129004070751949 4215 5369129 SGTC_1054 3429-0080 167 µM -1.13358930370316 0.161418554679269 no 2845 0.128483430926564 4259 1162877 SGTC_2719 novobiocin 32.65 µM -1.13442064415428 0.161218416009042 no 2846 0.128309071779769 4264 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1840 st055363 71 µM -1.13471545887822 0.161147480584993 no 2847 0.128247279017595 4257 676033 SGTC_478 N-arachidonylglycine 10 µM -1.13967232326788 0.159957858738221 no 2848 0.127211420927948 4202 5283389 SGTC_1056 3448-1962 115 µM -1.14039029985174 0.159786025485206 no 2849 0.12706186615005 4224 715507 SGTC_3195 9113082 49.47 µM -1.14275238298656 0.159221560916303 no 2850 0.126570707021297 4227 17018038 SGTC_2654 protoveratrine a 100 µM -1.14483090400171 0.158725940450543 no 2851 0.126139605448625 4230 5702278 A heart drug and vasodilator. SGTC_1061 3448-9325 110 µM -1.1449777331456 0.158690967532202 no 2852 0.126109190684818 4176 723482 SGTC_3218 9131285 49.47 µM -1.14527281068987 0.158620698925826 no 2853 0.126048082628784 4215 17156417 SGTC_1278 0874-0585 172 µM -1.14577766268208 0.158500522779976 no 2854 0.125943579946617 4310 766306 SGTC_2669 eugenol 100 µM -1.14629658741957 0.158377058978673 no 2855 0.125836227235117 4224 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1706 st031321 9.9705 µM -1.1479431065831 0.15798573304336 no 2856 0.125496025673079 4264 6103185 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.14912963327563 0.157704126780973 no 2857 0.125251265422717 4293 23665772 A membrane-active detergent. SGTC_3146 9095609 49.47 µM -1.15014025544589 0.157464529301371 no 2858 0.125043054283304 4290 17173999 SGTC_1322 1348-1070 12 µM -1.15041289136711 0.157399933995743 no 2859 0.124986926515866 4233 6758089 SGTC_2395 5646831 180.19 µM -1.15242186848283 0.156924486532579 no 2860 0.124573879467907 4262 6808628 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.15271348253365 0.156855551335881 no 2861 0.12451400282293 4257 77254 SGTC_2634 4'-methoxyflavone 100 µM -1.15277609809968 0.156840752122823 no 2862 0.124501148693747 4255 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3067 9117431 49.47 µM -1.15285363199737 0.156822428229606 no 2863 0.124485233318469 4268 17150885 SGTC_2066 5222451 176 µM -1.15517608485465 0.15627420684659 no 2864 0.124009163002075 4200 2281147 SGTC_1878 temozolomide 1 mM -1.15581780505282 0.156122949907072 no 2865 0.12387784429356 4173 5394 DNA alkylating agent. SGTC_1602 st001878 87.6 µM -1.15755095390179 0.155714919559113 no 2866 0.123523667109033 4232 595405 YLR310C CDC25 SGTC_1435 4092-0789 56.7 µM -1.15852101625582 0.155486847750186 no 2867 0.123325740131818 4225 2248285 SGTC_2766 oltipraz 83.91 µM -1.15893969038844 0.155388481201711 no 2868 0.123240384507484 4227 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1203 3992-3522 103 µM -1.15970667791342 0.155208385745488 no 2869 0.123084125194631 4369 5322312 SGTC_2584 androsterone 48.74 µM -1.16038978559065 0.155048102071538 no 2870 0.122945071795744 4176 2754130 A steroid. SGTC_1343 1487-0095 224 µM -1.16087848746296 0.154933500663499 no 2871 0.122845659251406 4259 4560101 YGL055W OLE1 SGTC_2747 doxorubicin 7.63 µM -1.16285098825279 0.15447151465709 no 2872 0.12244498284213 4228 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1798 st045719 60.953 µM -1.16351480611069 0.154316244667662 no 2873 0.122310347218035 4190 3980186 SGTC_1881 5652484 16 µM -1.16502366303785 0.153963700249296 no 2874 0.122004707285975 4235 2255129 SGTC_863 0466-0191 129 µM -1.16677922326873 0.153554184893975 no 2875 0.121649769781516 4297 765160 YPR165W RHO1 SGTC_12 0849-0099 9.267 µM -1.16752032549209 0.153381526465057 no 2876 0.121500152474688 4177 6071388 SGTC_1108 betulinic acid 729.144 nM -1.16854564287103 0.153142865084424 no 2877 0.121293369784016 4254 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1390 3413-2614 145 µM -1.1694913752803 0.152922946881344 no 2878 0.121102857055871 4273 3421432 SGTC_154 3389-1638 511.116 µM -1.17123495483132 0.152518048480842 no 2879 0.120752174281936 4256 5238686 SGTC_112 phenothiazine 287.218 µM -1.17208486046873 0.152320939395956 no 2880 0.120581493790615 4215 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_543 3844-1095 191 µM -1.17269084563001 0.152180503362764 no 2881 0.120459901893352 4269 4230703 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.17302996552198 0.152101950432664 no 2882 0.120391894636928 4243 689007 SGTC_1833 st055984 71 µM -1.1734638710644 0.152001480853833 no 2883 0.120304918467167 4259 676288 SGTC_628 1636-0253 16 µM -1.17372634725886 0.151940726649108 no 2884 0.120252326724816 4247 4456143 SGTC_1649 st011737 51.3 µM -1.1737351212372 0.151938696053785 no 2885 0.120250568983078 4257 1761035 SGTC_358 0075-0058 9.45 µM -1.17420093414456 0.151830917077586 no 2886 0.120157275983626 4138 1069125 SGTC_2013 4024628 200 µM -1.17513286251572 0.151615441633885 no 2887 0.119970782504077 4307 5230760 SGTC_781 4335-2806 94.4 µM -1.17530179494487 0.151576403763883 no 2888 0.119936998332716 4322 845254 SGTC_910 3454-3003 490 µM -1.17968768794743 0.150565225247217 no 2889 0.119062226248749 4175 820824 SGTC_3060 1327-0027 12.5 µM -1.18109859544183 0.150240894377435 no 2890 0.118781778927488 4183 16000455 YPR107C YTH1 SGTC_1217 1183-1422 255 µM -1.18408112163514 0.149556822840663 no 2891 0.118190476171323 4298 2849664 SGTC_3201 9113999 49.47 µM -1.18424690439914 0.149518860019333 no 2892 0.118157669970628 4270 16649224 SGTC_683 panaxydol 45 µM -1.18462259017428 0.149432855023191 no 2893 0.118083350592762 4264 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3267 9137951 49.47 µM -1.18550008702046 0.149232100083634 no 2894 0.117909890136972 4297 16643986 SGTC_2648 atorvastatin 78.68 µM -1.18773058053427 0.148722615742377 no 2895 0.117469785846417 4270 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2457 5731572 11.68 µM -1.18831353706013 0.148589649981611 no 2896 0.117354953193055 4324 2865357 SGTC_3074 9116018 49.47 µM -1.19209258353232 0.147729620432311 no 2897 0.11661247236238 4331 17027303 SGTC_1010 4112-3296 15.2 µM -1.19444866455549 0.147195117493763 no 2898 0.116151255150231 4327 704384 SGTC_1854 st056233 32.9 µM -1.19454905655304 0.147172371296011 no 2899 0.116131631603649 4217 5393174 SGTC_2564 betulinic acid 100 µM -1.19638025072336 0.146757884142946 no 2900 0.115774102330108 4332 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.19707689461849 0.146600406031732 no 2901 0.115638292417511 4186 17037758 SGTC_2379 9035213 200 µM -1.20003526776297 0.145932922027414 no 2902 0.115062821858867 4277 646551 SGTC_1732 st034308 51.822 µM -1.20262813157861 0.145349588033083 no 2903 0.114560128213915 4157 830119 SGTC_1195 1502-0147 41.1 µM -1.20396013519642 0.145050528945927 no 2904 0.114302493516175 4274 817940 SGTC_1320 1313-0481 95.3 µM -1.20490867733843 0.144837816603474 no 2905 0.114119279202108 4258 6813365 YLR208W SEC13 SGTC_3061 glucosamine 200 µM -1.21301764308704 0.143027940925872 no 2906 0.112561537567639 4228 91431 and experimental redox chemotherapeutic SGTC_393 acivicin 6.25 µM -1.2141479440985 0.14277688282848 no 2907 0.112345617312238 4149 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1410 3909-8106 77.9 µM -1.21620809339448 0.142320057123842 no 2908 0.111952830706912 4341 1039210 SGTC_2698 st077697 67.5 µM -1.21632557633223 0.142294035827909 no 2909 0.111930461125291 4264 3154499 SGTC_3327 9140648 26.9345 µM -1.21681698440409 0.142185228747404 no 2910 0.111836928199881 4324 8029710 SGTC_1612 st002233 45.4 µM -1.22064057658777 0.141340536477646 no 2911 0.111111067978198 4306 1035021 SGTC_602 3130-1533 38.1 µM -1.22153063017049 0.141144398539635 no 2912 0.110942587797006 4356 720941 SGTC_1654 st012436 41.8 µM -1.22292070564919 0.140838441913736 no 2913 0.110679823599971 4305 4323132 SGTC_1319 1306-0155 43.7 µM -1.22365639788621 0.140676697736615 no 2914 0.11054093725833 4347 3122360 SGTC_1546 5-methoxyflavanone 78.7 µM -1.22414890419382 0.140568489197086 no 2915 0.11044803017497 4317 147795 SGTC_1494 4358-1428 177 µM -1.22556720983494 0.14025718901627 no 2916 0.110180791784971 4322 1564571 SGTC_762 1165-0429 115 µM -1.22604352284758 0.140152749431981 no 2917 0.110091148589049 4309 5967793 SGTC_2226 7298446 200 µM -1.22832804539387 0.139652564160723 no 2918 0.109661923513638 4309 3283010 SGTC_564 3555-0129 330 µM -1.23312677417564 0.13860586205387 no 2919 0.108764234851549 4205 563260 SGTC_2493 resveratrol 26.09 µM -1.23727051712889 0.137706336650264 no 2920 0.107993334785486 4232 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1033 k072-0102 21.3 µM -1.23917046020986 0.137295231238145 no 2921 0.107641188819749 4282 5965931 SGTC_3177 9107506 49.47 µM -1.23999015621183 0.137118126340205 no 2922 0.107489517569116 4269 8897194 SGTC_1605 st000082 49.1 µM -1.24190866610691 0.136704220217671 no 2923 0.107135131150267 4285 1114022 SGTC_2245 6637752 200 µM -1.24323340044605 0.136418916401213 no 2924 0.106890918994156 4363 681890 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.24328955752861 0.136406831035029 no 2925 0.106880575427742 4312 688669 SGTC_2490 carminic acid 95.39 µM -1.24381096975021 0.136294654733763 no 2926 0.106784571050656 4285 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_414 piperonyl butoxide 100 µM -1.24441057755014 0.1361657335323 no 2927 0.106674245952909 4320 5794 A potent inhibitor of cytochrome P450. SGTC_2750 bromebric acid 70.15 µM -1.24600665718536 0.13582296855452 no 2928 0.106380975582811 4336 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2839 9003951 25.97 µM -1.24716428486214 0.135574733026613 no 2929 0.106168632790597 4376 2990634 SGTC_2270 7924575 90.91 µM -1.25150593119318 0.134646503485747 no 2930 0.105374975538742 4301 1262135 SGTC_64 000l-0018 272.079 µM -1.25208058542375 0.134523971965843 no 2931 0.105270250648832 4251 6811119 SGTC_2205 7238770 200 µM -1.25508415655397 0.133884776721002 no 2932 0.104724105632788 4391 279867 SGTC_3109 9122853 49.47 µM -1.26020660190646 0.132799482177534 no 2933 0.103797420945337 4357 1234709 SGTC_507 nimesulide 162 µM -1.26052265481199 0.132732718926836 no 2934 0.103740440303506 4391 4495 A COX2 inhibitor. SGTC_2822 7994718 71.43 µM -1.26053478817045 0.132730156328026 no 2935 0.103738253253306 4322 1018011 SGTC_1378 2093-0007 380 nM -1.26293534643961 0.132223821969348 no 2936 0.103306207920263 4387 3618014 SGTC_712 r015-0009 80.6 µM -1.26313989472881 0.132180739558109 no 2937 0.103269454417555 4363 6813872 YLR060W FRS1 SGTC_433 pimozide 108 µM -1.2653733436198 0.131710955358501 no 2938 0.102868763059934 4260 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1262 0737-0114 49.6 µM -1.2664606239824 0.131482673985296 no 2939 0.102674109109547 4374 765919 SGTC_1012 4112-3522 18 µM -1.26868220083647 0.131017089461768 no 2940 0.102277216608364 4347 3112398 SGTC_2206 7254556 146.969 µM -1.26897435871181 0.130955945650763 no 2941 0.102225104715519 4371 4398905 SGTC_808 0711-0032 135 µM -1.27270863690476 0.130176159421554 no 2942 0.101560725833716 4321 4252555 SGTC_1646 st011709 75.6 µM -1.27276514228917 0.130164384783452 no 2943 0.101550696965008 4298 5757843 SGTC_3308 9128332 17.569 µM -1.27500331914131 0.129698584328333 no 2944 0.101154033594282 4337 17332805 YDL196W YDL196W SGTC_745 0469-0705 296 µM -1.27734546574795 0.129212383594541 no 2945 0.100740154366216 4383 3486736 SGTC_2716 st080858 38.6235 µM -1.27829406781323 0.129015825443068 no 2946 0.100572879359811 4318 5296050 SGTC_2227 7312221 64.1025 µM -1.28130306029977 0.12839370982099 no 2947 0.100043619200879 4454 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1664 st014217 9.02 µM -1.28247466115819 0.128152043070522 no 2948 0.099838094068407 4402 3982782 SGTC_826 1683-5028 118 µM -1.28275849151978 0.128093544795878 no 2949 0.0997883502815067 4386 722377 SGTC_918 glabranin 770.725 nM -1.2853472695126 0.127560846071247 no 2950 0.0993354794367627 4354 124049 Also referred to as licorice root. SGTC_663 1486-0733 13.9 µM -1.28572148419779 0.127483970669528 no 2951 0.0992701402597352 4365 722445 YPR165W RHO1 SGTC_1557 sumaresinolic acid 42.3 µM -1.28714008250042 0.127192838784326 no 2952 0.0990227334477707 4333 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1827 berberine 7.24 µM -1.2959857714639 0.125387917359553 no 2953 0.0974901934848108 4270 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_562 3772-2733 112 µM -1.29878993494834 0.124819491246818 no 2954 0.0970080148677192 4348 2876874 YIL048W NEO1 SGTC_3208 9114115 49.47 µM -1.2995483721286 0.124666059876184 no 2955 0.096877902139757 4362 650895 SGTC_804 1595-0054 20.9 µM -1.30030757254373 0.12451260617416 no 2956 0.0967477868488176 4338 761523 Stimulates phospholipase C. SGTC_2880 9042983 58.44 µM -1.30378166478032 0.123812088817432 no 2957 0.0961540179294948 4323 6464714 SGTC_1872 amphotericin b 148 nM -1.30467646863165 0.123632107888271 no 2958 0.0960015187379495 4379 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2225 6654152 15.4 µM -1.30769431223268 0.123026449774352 no 2959 0.0954885066472094 4289 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1940 st075990 51.1 µM -1.30792507345694 0.122980223515133 no 2960 0.0954493620705059 4435 1084979 SGTC_1008 4106-0037 6 µM -1.30948408311494 0.122668240574797 no 2961 0.0951852129573128 4376 2905394 SGTC_2345 9052315 157.45 µM -1.31380191968016 0.12180707149212 no 2962 0.0944564357249395 4391 6469265 SGTC_760 0568-0725 82.9 µM -1.3141385909183 0.121740103189504 no 2963 0.094399784735451 4389 3916171 SGTC_775 4577-0580 57.3 µM -1.31469482929428 0.121629516806028 no 2964 0.0943062425263726 4410 2006902 SGTC_2934 9036370 36.88 µM -1.31596168418037 0.121377915497229 no 2965 0.0940934516367938 4358 6462800 SGTC_47 0149-0135 24.25 µM -1.31635769010231 0.121299342618615 no 2966 0.0940270081026677 4383 5239155 SGTC_2442 5158906 48.48 µM -1.31650703059747 0.121269720753905 no 2967 0.0940019601200753 4388 1893835 SGTC_984 1492-0255 2.91 µM -1.31985393886595 0.120607191721286 no 2968 0.0934418943576987 4351 1585198 SGTC_2492 derrusnin 100 µM -1.32165470058774 0.120251782681338 no 2969 0.0931415797510564 4412 1715307 Part of coumarin class of compounds. SGTC_503 tyrphostin 8 294 µM -1.32277926106544 0.120030207373362 no 2970 0.0929543979793684 4408 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_424 splitomicin 100 mM -1.32313720586368 0.11995974091537 no 2971 0.0928948768713225 4400 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1856 st057054 55.7 µM -1.3231961666655 0.119948136451787 no 2972 0.0928850752356768 4383 1266018 SGTC_1831 st055328 12 µM -1.32513600750267 0.119566784825934 no 2973 0.092563022638387 4368 1103068 SGTC_908 3448-7491 47.7 µM -1.32943427152671 0.118724841933042 no 2974 0.0918523686637168 4400 1203031 SGTC_2712 st079126 47.7 µM -1.33102574995948 0.118414168541223 no 2975 0.0915902691375797 4383 3152970 SGTC_3203 9113543 49.47 µM -1.33150964210186 0.118319821710556 no 2976 0.0915106872383289 4417 17018012 SGTC_1885 st057546 99.9 µM -1.33298266455309 0.118032946441315 no 2977 0.0912687463850116 4428 702008 SGTC_2910 7948405 25.97 µM -1.33422074194536 0.117792208204149 no 2978 0.0910657618629153 4341 2971328 SGTC_2673 kobusone 100 µM -1.33450138926217 0.117737686015106 no 2979 0.0910197959304563 4490 6710676 An epoxy ketone and protein crosslinker. SGTC_2619 obliquin 87.91 µM -1.3385527899166 0.116952597687468 no 2980 0.0903581519516787 4346 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2708 st078559 56 µM -1.34055768247883 0.116565460976622 no 2981 0.0900320522272266 4342 17250902 SGTC_1125 tnp00248 1.32998 µM -1.34100705011364 0.116478814711242 no 2982 0.0899590818085718 4431 24207736 SGTC_462 ag-879 158 µM -1.34302029306999 0.116091185633536 no 2983 0.089632701475658 4436 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2998 9066762 71.4286 µM -1.34550596083903 0.115613860330671 no 2984 0.0892309488180473 4432 4945196 SGTC_2445 5742597 35.57 µM -1.34611266723191 0.11549756587003 no 2985 0.0891330920267725 4410 1774255 SGTC_701 4424-0219 185 µM -1.34682452281073 0.115361222249004 no 2986 0.0890183773817163 4417 2911779 SGTC_299 1273-0059 1.44 µM -1.34701709656374 0.11532435774471 no 2987 0.0889873632535761 4192 2848077 SGTC_875 0709-0210 25.7 µM -1.34774203697781 0.115185657075224 no 2988 0.0888706832588067 4380 6251364 SGTC_1959 st077091 55.8 µM -1.35093211144435 0.114576718983831 no 2989 0.0883585903433249 4408 821356 YKL052C ASK1 SGTC_1821 st053465 65.6 µM -1.35354534193063 0.114079601775635 no 2990 0.0879407374734016 4413 675086 SGTC_1301 naphtanilide LB 4.81 µM -1.35499450928529 0.113804588533091 no 2991 0.0877096532017386 4461 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2675 theaflavin digallate 100 µM -1.3575145679676 0.113327474613587 no 2992 0.087308883894132 4343 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_662 k832-1615 104 µM -1.35812537407668 0.113212047951624 no 2993 0.0872119524935207 4422 5878478 SGTC_3012 9080433 71.4286 µM -1.3609946988563 0.112670941763158 no 2994 0.0867576823621549 4404 17688859 SGTC_3100 9120536 49.47 µM -1.36550961552173 0.111823248579125 no 2995 0.0860464665035719 4295 16421196 SGTC_874 0599-0792 117 µM -1.36593707187964 0.111743228986761 no 2996 0.0859793578135558 4407 765305 SGTC_2767 sibutramine 71.45 µM -1.36631483978193 0.111672545146902 no 2997 0.085920082590187 4421 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2541 muurolladie-3-one 83.07 µM -1.36688658678091 0.111565626888068 no 2998 0.0858304284565238 4369 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1569 carminic acid 40.6 µM -1.37024688467408 0.110938722093911 no 2999 0.0853049236535179 4498 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3263 9137018 49.47 µM -1.37194427899611 0.110623013353402 no 3000 0.0850403923411339 4365 43844957 SGTC_1560 lithocholic acid 53.1 µM -1.37356187487691 0.110322746539342 no 3001 0.0847888698634889 4354 9903 A bile acid which acts as a detergent. SGTC_3131 9127911 49.47 µM -1.37372864754293 0.110291822570196 no 3002 0.0847629698777081 4425 45595681 SGTC_1524 corynanthine 62.1 µM -1.37482367235809 0.110088931024474 no 3003 0.0845930586121405 4491 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_514 4466-0038 2.65 nM -1.37614947640258 0.109843638105109 no 3004 0.084387680186863 4207 5722064 SGTC_2752 diclazuril 33.15 µM -1.37628577409199 0.109818443315148 no 3005 0.0843665877321972 4337 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2096 5468907 200 µM -1.3763655878635 0.10980369157031 no 3006 0.0843542381609964 4412 759785 SGTC_2838 9002687 71.43 µM -1.38162402479587 0.108834921770862 no 3007 0.0835435866425897 4402 6457060 SGTC_276 colchicine 750 µM -1.38299087872052 0.108584113559725 no 3008 0.0833338313527472 4464 2833 A microtubule depolymerizer. SGTC_1897 st060201 15 µM -1.38391689882094 0.108414431706453 no 3009 0.0831919508590761 4441 611878 SGTC_3236 9132701 49.47 µM -1.38651201031702 0.107939926010687 no 3010 0.0827953077358521 4424 24282524 SGTC_1548 st061468 90.8 µM -1.38877719801562 0.107526969559629 no 3011 0.0824502555066508 4460 390799 SGTC_1327 1436-0082 2.18 µM -1.39056222089406 0.107202352880422 no 3012 0.0821791095799349 4443 15992205 SGTC_2331 7980721 200 µM -1.39118912226435 0.107088515094577 no 3013 0.0820840424627061 4390 2981221 SGTC_3339 9145883 14.936 µM -1.39432735850651 0.106519959461027 no 3014 0.0816093864731572 4347 2030670 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.40149470365158 0.105229627689994 no 3015 0.0805330951224782 4365 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_222 nsc-310342 10.666 µM -1.40242901466795 0.105062261201873 no 3016 0.0803935870661002 4450 432556 SGTC_2174 5790901 200 µM -1.40582176588236 0.104456125702807 no 3017 0.0798885285399782 4412 786020 SGTC_1209 2323-2347 50.3 µM -1.40717398534969 0.104215251043162 no 3018 0.0796879018383262 4443 5412760 SGTC_3237 9133362 49.47 µM -1.40887038279316 0.103913636714092 no 3019 0.079436749299297 4404 43845137 SGTC_435 c-PAF 6.7 µM -1.41045955089745 0.103631662222374 no 3020 0.079202016025425 4387 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_201 4262-0159 12.803 µM -1.41049065063557 0.103626149575881 no 3021 0.0791974275819216 4486 1341029 SGTC_1556 plumbagin 1.48 µM -1.41093633281824 0.103547172659089 no 3022 0.0791316939102766 4371 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2357 9067248 200 µM -1.4122597404163 0.103312916241781 no 3023 0.0789367479811434 4394 9150235 SGTC_533 1222-0222 6.71 µM -1.41426816299675 0.1029581407171 no 3024 0.0786415905015819 4456 3982874 SGTC_724 3910-0327 137 µM -1.41731086338649 0.102422353738602 no 3025 0.0781960302121187 4482 2885483 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.41867142170344 0.102183431061824 no 3026 0.0779974163543942 4466 390807 SGTC_327 1273-0057 3.96 µM -1.42114969080409 0.101749273607428 no 3027 0.0776366233549407 4354 3108138 SGTC_476 mead acid 10 µM -1.42242127457599 0.101527032233155 no 3028 0.0774519953487845 4512 5312531 An omega 9 fatty acid. SGTC_570 0987-0065 62.6 µM -1.42423071945447 0.101211395813861 no 3029 0.0771898475295792 4299 3104428 SGTC_3319 9138450 16.7555 µM -1.42503117759532 0.101071993644306 no 3030 0.077074094477051 4375 2029690 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.42729774152581 0.100678024052806 no 3031 0.0767470456650462 4470 23847180 SGTC_1234 0326-0494 15.5 µM -1.42735855142955 0.100667469647533 no 3032 0.0767382857928596 4517 1547813 SGTC_3028 9087778 49.47 µM -1.42795835009512 0.100563409474755 no 3033 0.0766519234963264 4425 17217395 SGTC_1174 0739-0097 51.1 µM -1.42912136014565 0.10036186036111 no 3034 0.0764846775835338 4483 728447 SGTC_2336 9001819 198.65 µM -1.43022659907824 0.100170596293608 no 3035 0.0763259968060844 4479 2989602 SGTC_1951 sophoraflavanone G 9.2 µM -1.43229734758159 0.0998129651929209 no 3036 0.0760293709346163 4403 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1968 st069590 43.6 µM -1.43362291460699 0.0995845217055091 no 3037 0.0758399503674833 4415 6384066 SGTC_768 0384-0033 77.3 µM -1.43640412018325 0.0991064609280066 no 3038 0.0754436907152505 4418 3965305 YMR134W ERG29 SGTC_3110 9122132 49.47 µM -1.43650619569152 0.0990889471804247 no 3039 0.0754291773121613 4485 918317 SGTC_2913 7966556 36.57 µM -1.4365438575374 0.0990824858684451 no 3040 0.0754238229749447 4354 2976516 SGTC_2113 5491891 107.031 µM -1.43871796866354 0.0987100149017112 no 3041 0.0751152230989482 4457 789979 SGTC_1688 st021091 57.6 µM -1.43877347576909 0.0987005188010844 no 3042 0.0751073568770709 4485 3656366 SGTC_2387 9077560 195.08 µM -1.4396139171212 0.0985568186222419 no 3043 0.0749883299883276 4460 5303272 SGTC_2223 6903751 107.57 µM -1.44049428534638 0.0984064559877972 no 3044 0.0748638028274354 4440 5598863 SGTC_1522 st012842 45.6 µM -1.4407420814839 0.0983641639169433 no 3045 0.0748287807909808 4301 3491067 YOR116C RPO31 SGTC_173 1273-0061 2.693 µM -1.44083809515589 0.0983477805691702 no 3046 0.0748152141484366 4415 2847414 YPL266W DIM1 SGTC_2243 6634756 200 µM -1.44088135961119 0.0983403987672915 no 3047 0.0748091015345024 4491 885676 SGTC_483 fpl-64176 144 µM -1.44218600701808 0.098117989780831 no 3048 0.0746249535017203 4585 3423 SGTC_2111 5486399 200 µM -1.44475148416746 0.097681716849609 no 3049 0.0742638514833902 4434 689674 SGTC_621 3584-0052 32.1 µM -1.44904244100493 0.0969551987160422 no 3050 0.0736628653139852 4484 2273927 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.45459640316358 0.0960207369385217 no 3051 0.0728905136822015 4492 5357218 A potent inhibitor of glutathione S-transferases. SGTC_929 2805-0021 398 µM -1.45855357059176 0.0953589898521654 no 3052 0.0723440102407821 4505 3098024 SGTC_2086 5274770 176.623 µM -1.45943489859638 0.0952120658269708 no 3053 0.0722227232840546 4515 689278 SGTC_1292 0kpi-0043 232 µM -1.46231877800498 0.0947324665722079 no 3054 0.0718269375555936 4495 3333905 SGTC_2720 fluspirilene 36.88 µM -1.47076517850189 0.0933380473098716 no 3055 0.0706773162664224 4464 3396 An atypical antipsychotic. SGTC_477 mead ethanolamide 10 µM -1.4709860543647 0.0933017873807546 no 3056 0.0706474441714359 4479 16061185 SGTC_2597 laccaic acid a 100 µM -1.47169800300841 0.0931849816741888 no 3057 0.0705512235602804 4459 5491415 A textile dye. SGTC_954 1189-0853 2.85 µM -1.47499329824891 0.0926457471193664 no 3058 0.070107172596605 4405 2828194 SGTC_1795 st049545 62.3 µM -1.48125432597185 0.0916275715405087 no 3059 0.0692694072680699 4429 5291882 SGTC_191 3914-0123 66.505 µM -1.48172745638867 0.0915509688085289 no 3060 0.069206414185445 4542 3144412 SGTC_1394 3474-0001 65.7 µM -1.48183085926402 0.0915342335667717 no 3061 0.0691926528965092 4468 5017666 YIL048W NEO1 SGTC_3071 9117417 49.47 µM -1.48762570009601 0.0905999872149569 no 3062 0.0684248159443759 4435 45595590 YGL055W OLE1 SGTC_1875 nocodazole 6 µM -1.48765734786409 0.0905949044568996 no 3063 0.0684206406267136 4514 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2354 9060492 162 µM -1.49191901112131 0.0899123960852158 no 3064 0.0678601890875469 4506 6471895 SGTC_809 3998-0021 90 µM -1.4993663419319 0.0887288864958266 no 3065 0.0668893101483529 4445 715485 SGTC_2817 7995342 71.43 µM -1.50199477517806 0.0883139649048652 no 3066 0.0665492290949495 4470 18879975 SGTC_1748 st037455 53.6035 µM -1.50417570888616 0.0879707841919936 no 3067 0.066268065281775 4499 580690 SGTC_1728 st035614 33.7865 µM -1.50503639127758 0.0878356255616145 no 3068 0.0661573604622211 4450 15945546 SGTC_2483 5729050 27.16 µM -1.51055159400318 0.0869732110893855 no 3069 0.0654513674013967 4479 2865180 SGTC_1132 3456-3614 2.5 µM -1.5128309805403 0.0866186356193671 no 3070 0.0651612986136172 4483 3125502 SGTC_2081 5214970 32.255 µM -1.51302808074068 0.0865880260505987 no 3071 0.0651362630885886 4436 2063512 SGTC_48 0382-0018 55 µM -1.52029015174314 0.0854658591967932 no 3072 0.0642190340452383 4532 762596 SGTC_1340 1486-1359 257 µM -1.52401534084251 0.0848944703538837 no 3073 0.0637524395176715 4454 4309068 SGTC_3055 9094636 49.47 µM -1.5254951308514 0.0846682889703623 no 3074 0.0635678235542888 4521 25236176 SGTC_2798 7813637 45.45 µM -1.53932769572879 0.0825758381937056 no 3075 0.0618621579265925 4496 956368 SGTC_1114 scopoletin 1.73284 µM -1.5433607951094 0.0819731416528894 no 3076 0.0613716302051158 4548 5280460 A coumarin with genotoxic properties. SGTC_1412 3909-8563 178 µM -1.54351392464163 0.0819503238365995 no 3077 0.061353065797002 4603 23767530 SGTC_676 falcarinol 140 µM -1.54496329664028 0.0817345900425028 no 3078 0.0611775707567362 4531 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1934 st074720 32.6 µM -1.54891999863411 0.0811478290288387 no 3079 0.0607004764056726 4463 17250992 SGTC_1422 4031-0024 15.5 µM -1.54910053679235 0.0811211320588926 no 3080 0.0606787769489949 4462 782427 SGTC_887 0885-0007 9.62 µM -1.55032768201627 0.0809398443154811 no 3081 0.0605314431964234 4538 5719458 SGTC_1628 st004252 77.7 µM -1.55083260857694 0.0808653397337395 no 3082 0.0604709019384561 4510 692968 SGTC_1237 0330-0133 46.1 µM -1.5519660079601 0.0806982892310981 no 3083 0.0603351786275495 4459 X1237 YHR072W ERG7 SGTC_1786 berberine 21.6 µM -1.55302783288494 0.0805420245719115 no 3084 0.0602082426909326 4435 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2103 5378138 10 µM -1.5663138078747 0.0786060573591339 no 3085 0.0586375850112991 4596 244142 SGTC_2739 tacrine 100.86 µM -1.56681692301075 0.0785334451083509 no 3086 0.0585787452992074 4586 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1395 3486-0190 4.35 µM -1.5727240508924 0.0776846961405205 no 3087 0.0578913641635621 4508 6748079 SGTC_2982 9019404 25.97 µM -1.57338915787624 0.0775895699678742 no 3088 0.0578143679797814 4484 22333232 SGTC_1501 4491-0275 38.4 µM -1.57363066522665 0.0775550505491705 no 3089 0.0577864297873071 4543 5104718 SGTC_1168 k815-0004 80.5 µM -1.57568478702128 0.0772619195882189 no 3090 0.0575492325702127 4527 642433 SGTC_1449 4112-4002 201 µM -1.57789138463061 0.0769479683080939 no 3091 0.0572952822903127 4565 2059539 SGTC_922 1866-0035 480 µM -1.57875997876295 0.0768246524115196 no 3092 0.0571955607704654 4470 3156169 SGTC_1468 k284-1086 134 µM -1.57909928192395 0.0767765217527646 no 3093 0.0571566431905974 4541 15996457 SGTC_2521 angolensin 13.4 µM -1.58588630827529 0.0758185813490961 no 3094 0.0563825511283151 4566 821428 A flavenoid. SGTC_2046 4110841 106 µM -1.58652243540056 0.0757292652097588 no 3095 0.0563104234568443 4544 44119630 YMR134W ERG29 SGTC_1126 isoteolin 1.0172 µM -1.59173523466912 0.0750003731848266 no 3096 0.055722103911515 4487 133323 SGTC_3249 9135183 49.47 µM -1.59507850498715 0.0745357166105064 no 3097 0.0553473407709776 4498 4902779 SGTC_1808 st050063 61.5 µM -1.59565474530864 0.0744558516892335 no 3098 0.0552829487999182 4505 4011993 SGTC_2677 mitomycin C 100 µM -1.59776027357365 0.0741645881348354 no 3099 0.0550481694845139 4618 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2491 paeonol 100 µM -1.5982193542119 0.0741011979564562 no 3100 0.0549970839367348 4518 11092 Increases levels of cortical cytochrome oxidase. SGTC_665 3914-0008 307 µM -1.59944040872665 0.0739327953348424 no 3101 0.0548613898229428 4518 1069549 SGTC_550 4123-0385 25.7 µM -1.5995523392207 0.0739173730034382 no 3102 0.0548489643922816 4569 5731123 SGTC_1111 tnp00062 510.699 nM -1.60311740858449 0.0734274453516613 no 3103 0.0544543676272169 4547 676306 SGTC_868 0527-0199 213 µM -1.60442753992747 0.0732480266469853 no 3104 0.0543099222855516 4546 2849450 SGTC_2374 9071832 200 µM -1.60662312819997 0.0729480994566471 no 3105 0.0540685329138781 4489 17381698 SGTC_1023 4482-3888 16 µM -1.61231780951723 0.072174561864625 no 3106 0.0534463998887221 4559 3303168 SGTC_2743 auranofin 4.32 µM -1.61458162900223 0.0718688080208155 no 3107 0.0532006632190217 4622 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2180 6301957 200 µM -1.61632709379673 0.0716337426622021 no 3108 0.0530118059704147 4570 845462 SGTC_1991 st073000 8.92 µM -1.61804378928097 0.071403127521004 no 3109 0.0528265805113406 4569 4301969 YIL048W NEO1 SGTC_2188 6126565 140.678 µM -1.62208161945005 0.0708629456131017 no 3110 0.0523929365953686 4472 874518 SGTC_292 k038-0015 474 µM -1.62247587373896 0.0708103708671723 no 3111 0.0523507474311514 4539 46368540 SGTC_1554 st069299 38.7 µM -1.62269675077409 0.0707809294907112 no 3112 0.0523271231642024 4508 24207999 SGTC_827 3253-0474 693 µM -1.6239317471992 0.0706164863203222 no 3113 0.0521951880358859 4562 5402065 SGTC_2905 7799065 20.05 µM -1.624672969571 0.0705179316170737 no 3114 0.0521161299295176 4446 1296806 SGTC_780 0109-0199 192 µM -1.62476184992067 0.070506120975539 no 3115 0.0521066564220432 4578 610414 SGTC_1087 pterostilbene 9.05 µM -1.62810031159075 0.0700635982346125 no 3116 0.051751808750668 4557 5281727 Similar to reservatol, lowers cholesterol. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.62907876521691 0.0699343071075942 no 3117 0.0516481729347744 4564 688667 SGTC_2073 5212005 126 µM -1.63312390893176 0.0694017366778051 no 3118 0.0512214695294001 4492 691789 SGTC_2287 7945887 168.79 µM -1.63391680382553 0.06929771382741 no 3119 0.0511381604280205 4573 1245853 SGTC_1512 0259-0544 12.2 µM -1.63712046400573 0.0688786363400517 no 3120 0.0508026507429474 4533 18476 SGTC_2229 7354935 190 µM -1.6405085551704 0.0684375616231123 no 3121 0.0504497355652787 4553 318112 SGTC_1141 3253-0389 52.6 µM -1.64070150439655 0.0684125084875127 no 3122 0.0504296962498598 4557 5402031 SGTC_1364 1653-0028 37.6 µM -1.64822886787288 0.0674406441954346 no 3123 0.0496528575466195 4579 5718652 SGTC_2449 5812982 45.77 µM -1.64943826407578 0.0672854978623381 no 3124 0.0495289405430346 4496 776185 SGTC_2722 naftopidil 47.16 µM -1.65115283464193 0.0670660187308616 no 3125 0.0493536855691292 4506 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2179 6298986 200 µM -1.65248471223676 0.0668959098633457 no 3126 0.0492178895479582 4526 738374 SGTC_3178 9107506 49.47 µM -1.65267051456126 0.066872205540478 no 3127 0.0491989691911506 4548 8897194 SGTC_10 0279-0212 42.575 µM -1.65445389939612 0.0666450149419045 no 3128 0.0490176613909395 4588 39851 YBR002C RER2 SGTC_3021 9087658 49.47 µM -1.65721756607216 0.0662941241270136 no 3129 0.0487377481736017 4598 25237042 SGTC_1506 4226-2149 212 µM -1.66134321046024 0.065772973132649 no 3130 0.0483222681610379 4568 991114 SGTC_3242 9133940 49.47 µM -1.66524490548566 0.0652830384927848 no 3131 0.0479319526614935 4577 17248444 SGTC_2588 indole-3-carbinol 100 µM -1.66601406822398 0.065186789903893 no 3132 0.0478553062116941 4539 3712 Induces cell cycle arrest. SGTC_172 1112-0046 2.638 µM -1.67911234186712 0.063564597471807 no 3133 0.0465650756698711 4570 2802135 YIL048W NEO1 SGTC_1659 st012954 42.1 µM -1.67979964879346 0.0634803513650268 no 3134 0.0464981517641674 4562 24207262 SGTC_2690 usnic acid 100 µM -1.68133305210143 0.0632927088864398 no 3135 0.0463491206737347 4578 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3106 9121286 49.47 µM -1.68414378199847 0.0629498815475119 no 3136 0.0460769424031859 4532 15943471 SGTC_1450 4112-4260 37.6 µM -1.69083842156621 0.0621391565845274 no 3137 0.0454338334027527 4576 1633175 SGTC_1230 0170-0365 3.77 µM -1.69236269254911 0.0619557098350749 no 3138 0.0452884205502306 4596 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2947 9072639 7.68 µM -1.69398008744135 0.0617615180199331 no 3139 0.0451345334781908 4530 16488146 SGTC_1559 coumarin 343 70.1 µM -1.69691148735431 0.0614107721479965 no 3140 0.0448566979529267 4619 108770 A hepatotoxic, DNA x-linker. SGTC_1404 3909-7820 48.3 µM -1.70723002741493 0.0601885116896097 no 3141 0.0438896529692864 4576 23741373 SGTC_2799 7812892 81.82 µM -1.70763850630627 0.060140520939441 no 3142 0.0438517194235768 4605 20205235 SGTC_1288 0973-0013 65.5 µM -1.70864767168545 0.0600220860756973 no 3143 0.0437581162720669 4616 4315430 SGTC_404 fumagillin 50 µM -1.71404976723341 0.0593912032120407 no 3144 0.0432597930962803 4600 12015870 A methionine aminopeptidase binder. SGTC_2132 5317594 122.667 µM -1.72259303899879 0.0584041042854096 no 3145 0.042481072348075 4535 794577 SGTC_329 k048-0121 21.3 µM -1.72307713878855 0.0583485589304368 no 3146 0.0424372881850638 4608 6832902 SGTC_585 0kpi-0023 191 µM -1.72333906778714 0.0583185226378054 no 3147 0.0424136133692779 4538 64601 SGTC_252 miconazole 1.30953 nM -1.72524305517582 0.058100550765708 no 3148 0.0422418397360327 4520 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_983 1491-0821 12.2 µM -1.72761981511359 0.0578293539765976 no 3149 0.0420282039455872 4607 46495113 SGTC_2704 st078022 71.1 µM -1.72819746994448 0.0577635920601893 no 3150 0.0419764135940668 4638 54697681 SGTC_320 4092-0846 5.34 µM -1.73647432451839 0.0568277738673857 no 3151 0.0412400001977284 4572 1359356 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.7404256340189 0.0563852521809487 no 3152 0.0408921538199403 4594 688798 SGTC_431 k089-0097 107 µM -1.74296724993638 0.0561020457107367 no 3153 0.0406696678347202 4319 5499420 SGTC_1446 4239-0190 62 µM -1.74307220464893 0.0560903750081154 no 3154 0.0406605015547419 4620 1340085 SGTC_1011 4112-3381 17.4 µM -1.74459321176523 0.0559214576461436 no 3155 0.0405278516480232 4631 2877139 SGTC_1505 k297-0037 20.6 µM -1.74558399249583 0.0558116412556413 no 3156 0.0404416328968597 4599 4089396 SGTC_70 0141-0289 43.283 µM -1.74602138175909 0.0557632159706838 no 3157 0.0404036182498476 4568 352408 SGTC_566 0958-0068 16.5 µM -1.74884759921867 0.055451111822885 no 3158 0.0401586832151585 4515 6815365 SGTC_3281 9140613 49.47 µM -1.74905756304515 0.0554279802968261 no 3159 0.0401405348738957 4597 16013766 SGTC_962 1254-0300 21.5 µM -1.7553719058786 0.0547358880680938 no 3160 0.0395978571500969 4595 7340576 SGTC_2718 lomofungin 53.02 µM -1.75626963609923 0.0546380482232913 no 3161 0.0395211896533351 4572 5351222 A RNA synthesis inhibitor. SGTC_2075 5212009 200 µM -1.75863648981043 0.0543807576140391 no 3162 0.0393196354943786 4561 780898 SGTC_1914 st062367 72.6 µM -1.76124770817436 0.0540980161459745 no 3163 0.0390982432113638 4578 978205 SGTC_1263 0774-1208 64.8 µM -1.76452600510006 0.0537446924905897 no 3164 0.0388217305220441 4590 906585 SGTC_534 k292-0788 63.4 µM -1.76470652772851 0.0537252895930355 no 3165 0.0388065504681681 4659 4146317 SGTC_1131 3454-3128 32.3 µM -1.76879556551936 0.0532872767273953 no 3166 0.0384639985347058 4589 710982 SGTC_1962 st076595 64.5 µM -1.76893018086528 0.053272905161326 no 3167 0.0384527634105287 4573 279619 SGTC_94 0334-0113 514.748 µM -1.78164701474234 0.0519290510380393 no 3168 0.0374034062169629 4627 6795178 SGTC_2373 9071805 200 µM -1.78292243354011 0.0517957705986046 no 3169 0.0372994653585934 4617 10149009 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.78380194870883 0.0517040203239592 no 3170 0.0372279264129504 4594 1241132 A phosphatase inhibitor. SGTC_636 0kpi-0074 126 µM -1.79918488092647 0.0501200834425181 no 3171 0.0359947201191728 4645 616434 SGTC_2549 cedrol 20.94 µM -1.80374511845804 0.0496580367386044 no 3172 0.0356356364830154 4590 6708665 A sedative which affects the nervous system. SGTC_369 0957-0393 4.5 µM -1.80387423944073 0.0496450037505673 no 3173 0.0356255121007065 4618 6997992 SGTC_2021 4019055 173 µM -1.81263989099465 0.0487665953750374 no 3174 0.0349436904891028 4411 44827708 YER133W GLC7 SGTC_245 methotrexate 289.6 µM -1.82470191799532 0.0475782131843006 no 3175 0.0340230118414595 4592 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3211 9128781 49.47 µM -1.82554982558809 0.0474955554691217 no 3176 0.0339590497253858 4536 17194361 SGTC_612 0302-0167 22.4 µM -1.82615937706112 0.0474362048535551 no 3177 0.0339131291911073 4628 235821 SGTC_1044 1222-0021 1.78 µM -1.82872194725912 0.0471873430585696 no 3178 0.0337206364513473 4575 4306703 SGTC_3333 9141820 12.094 µM -1.83059546702871 0.0470060609267746 no 3179 0.0335804728266163 4618 1939433 SGTC_1411 3909-8223 150 µM -1.83583881299516 0.0465016809821798 no 3180 0.0331907496254445 4676 X1411 SGTC_3015 9080845 49.47 µM -1.84046655270553 0.0460601360724024 no 3181 0.0328498852094663 4661 5296973 SGTC_2408 sulbentine 18.36 µM -1.847328850393 0.045411592459835 no 3182 0.0323497470328753 4510 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3064 1327-0027 10 µM -1.85566064907338 0.0446340627946683 no 3183 0.0317509715395188 4631 16000455 YPR107C YTH1 SGTC_2272 7805186 180 µM -1.8600795927144 0.0442260560845774 no 3184 0.0314371329775757 4649 2956062 YPR165W RHO1 SGTC_3345 9148410 3.559 µM -1.86260615492985 0.0439941295572026 no 3185 0.0312588488812129 4587 4903596 SGTC_38 0929-0051 58.268 µM -1.86494885700783 0.0437799578224198 no 3186 0.0310942866156038 4595 1379719 SGTC_2974 9094440 9.66 µM -1.86501614679126 0.0437738185847625 no 3187 0.0310895704786625 4618 25236134 SGTC_1283 0922-0125 16.4 µM -1.86864797731989 0.043443494643526 no 3188 0.0308359030846253 4645 3360884 SGTC_97 0535-0701 19.132 µM -1.87554564016592 0.0428216765887222 no 3189 0.0303588484049368 4564 2832013 YGL099W LSG1 SGTC_2927 9011802 47.9 µM -1.87578079263897 0.0428006052693245 no 3190 0.0303426932474587 4609 43912568 SGTC_1330 1469-0054 61.8 µM -1.87823144946527 0.0425815075426852 no 3191 0.0301747548099367 4614 7102664 SGTC_2014 4013930 200 µM -1.88429182812336 0.0420435804092541 no 3192 0.0297627560919392 4622 64556 SGTC_2035 5154463 94.595 µM -1.88474291216588 0.0420037625409024 no 3193 0.0297322778729062 4656 2769623 SGTC_2827 7993847 71.43 µM -1.88591199889712 0.0419007075595591 no 3194 0.0296534071607887 4673 2985692 SGTC_1323 1348-1351 11.2 µM -1.89033371200479 0.0415127835450733 no 3195 0.0293566713910509 4654 6989654 SGTC_656 4090-1979 187 µM -1.89125593415757 0.0414322434017432 no 3196 0.0292950939758043 4681 22330961 SGTC_1553 gossypol 38.6 µM -1.89634054780623 0.0409904613545995 no 3197 0.0289575139177669 4631 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2875 9039966 71.43 µM -1.89677752943593 0.0409526727065987 no 3198 0.0289286531097471 4665 6463691 SGTC_256 clotrimazole 625 nM -1.90029605159603 0.0406494319044846 no 3199 0.0286971396120218 4607 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_82 0054-0107 293.755 µM -1.9095491128161 0.0398606557731388 no 3200 0.0280956462251274 4636 3104697 SGTC_116 0155-0182 31.788 µM -1.9215326551213 0.0388576578245876 no 3201 0.0273322947972187 4538 771486 SGTC_280 3448-3607 3.04 µM -1.92384864694175 0.0386662043878508 no 3202 0.0271867788466299 4640 626179 SGTC_103 0844-0104 51.839 µM -1.93615757017494 0.0376615346279435 no 3203 0.0264242026651675 4485 5375804 SGTC_157 1348-1695 65.819 µM -1.93825538418376 0.037492452834764 no 3204 0.0262960363654359 4592 5380510 SGTC_1726 st035556 14.5795 µM -1.95112348953064 0.0364688123794872 no 3205 0.0255211787954175 4673 5919439 SGTC_501 nsc-95397 161 µM -1.95202920659753 0.0363976338032347 no 3206 0.0254673685754843 4668 262093 SGTC_1976 st070609 63.5 µM -1.95553610362669 0.0361231051014476 no 3207 0.0252599131567882 4638 682556 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.96023431655759 0.0357579769445459 no 3208 0.0249842046114487 4682 5024745 SGTC_1676 st018489 23.4 µM -1.96122594625332 0.0356812988938501 no 3209 0.0249263357172964 4630 3696235 SGTC_1583 clindamycin 39.6 µM -1.96153924590104 0.0356571009419544 no 3210 0.0249080757568706 4673 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_362 0310-0100 9.03 µM -1.96533168446203 0.0353652543197557 no 3211 0.0246879303483686 4673 790235 SGTC_3213 9129884 49.47 µM -1.96536741612816 0.0353625139378179 no 3212 0.0246858639661836 4633 17190742 SGTC_207 4185-0010 4.486 µM -1.9825016732959 0.0340683534037506 no 3213 0.0237115601464529 4697 3761753 SGTC_1629 st005085 44.9 µM -1.98369200941959 0.0339799125787994 no 3214 0.0236450924473463 4648 24207091 SGTC_1687 st020778 55.3625 µM -1.98463254075002 0.0339101656232391 no 3215 0.0235926845879366 4710 4259299 SGTC_3247 9135149 49.47 µM -1.99938319257927 0.0328316237789629 no 3216 0.022783454524251 4703 8934436 YOR116C RPO31 SGTC_151 3013-0144 2.285 µM -2.00717819913716 0.0322731853941785 no 3217 0.0223653460340181 4459 906558 YHR107C CDC12 SGTC_3086 9117350 49.47 µM -2.01289587044499 0.0318685716581319 no 3218 0.02206279255411 4691 2679265 SGTC_895 0964-0006 13.7 µM -2.02481578358346 0.0310385197167747 no 3219 0.0214431418714723 4685 6738897 SGTC_1456 k015-0012 13 µM -2.02530210854926 0.0310050375562417 no 3220 0.0214181760765677 4682 2989616 SGTC_312 4092-0653 6.84 µM -2.03254491972249 0.0305099168832569 no 3221 0.0210492605622752 4591 1148278 SGTC_722 3534-0461 190 µM -2.03909253540572 0.0300679738971809 no 3222 0.0207203965322676 4696 658262 SGTC_2435 5706476 10.6 µM -2.04886454994994 0.0294182769661088 no 3223 0.0202376808213527 4679 5725375 SGTC_2222 6885208 172.143 µM -2.05416835366288 0.0290705587718023 no 3224 0.0199797000956587 4727 609514 SGTC_1139 k015-0024 46.9 µM -2.06012063116196 0.0286844002795748 no 3225 0.0196935050075133 4715 2766652 SGTC_1989 st071868 50.2 µM -2.06670439901031 0.028262251598504 no 3226 0.0193810082077215 4695 16414057 SGTC_1100 amiodarone 5.07 µM -2.06833767043976 0.0281583311833978 no 3227 0.0193041409114022 4709 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_690 glyoxal 20.3 µM -2.06895629179575 0.0281190532215721 no 3228 0.019275094215585 4528 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2966 9084041 48.03 µM -2.07236567137509 0.0279034000330911 no 3229 0.0191156761298982 4657 17741380 SGTC_1698 5-fluorocytosine 1.055 µM -2.07903629900853 0.0274854473339051 no 3230 0.0188070071181342 4702 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_924 2046-0044 21.3 µM -2.09811259008086 0.0263189240138155 no 3231 0.0179476003239395 4684 3623589 SGTC_488 nitrendipine 139 µM -2.12197348716422 0.0249183558818399 no 3232 0.0169199822637458 4719 4507 Dihydropyridine L-type calcium channel blocker. SGTC_970 1315-0089 19.5 µM -2.12256293474477 0.0248845637034496 no 3233 0.0168952468460331 4693 6811083 YLR033W RSC58 SGTC_359 0081-0058 15.9 µM -2.12652587334684 0.0246583704798217 no 3234 0.0167297486319131 4684 3494159 SGTC_107 0358-0022 2.6945 µM -2.13371798803533 0.0242522710175668 no 3235 0.0164329363493446 4722 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_128 0906-2981 13.371 µM -2.14219635592631 0.0237807717627162 no 3236 0.0160888423163232 4709 6740226 SGTC_860 0443-0016 25.1 µM -2.14623891326553 0.0235586845325597 no 3237 0.0159269612252919 4721 5337942 SGTC_1842 st055362 61.2 µM -2.1580735694047 0.0229185268693976 no 3238 0.0154610561630673 4713 676032 SGTC_2551 apiole 73.87 µM -2.16058268250777 0.0227847039570315 no 3239 0.0153637951642862 4688 10659 A possible DNA adduct former. SGTC_1161 k007-0610 110 µM -2.16339431334856 0.0226355292746315 no 3240 0.0152554322936202 4652 5843850 SGTC_2006 4011487 200 µM -2.16453453883307 0.0225752682233807 no 3241 0.0152116744025933 4663 45595294 SGTC_417 st075190 100 µM -2.16766389926963 0.0224105757627117 no 3242 0.015092134050456 4713 222757 SGTC_2813 7971799 71.43 µM -2.16796189102071 0.0223949459833886 no 3243 0.0150807930909017 4687 2234054 SGTC_1 0258-0098 57.368 µM -2.17049213622903 0.0222626037691588 no 3244 0.0149847918579859 4640 6790032 YDR047W HEM12 SGTC_3087 9117406 49.47 µM -2.17969912467585 0.0217865960642006 no 3245 0.0146398857488751 4708 42546093 SGTC_3151 9099821 49.47 µM -2.18074638938314 0.021733000337071 no 3246 0.0146010899095635 4674 17174189 SGTC_1818 st052136 56.3 µM -2.18344604581009 0.0215953537800647 no 3247 0.0145014890841077 4457 674169 SGTC_1208 2323-2347 50.3 µM -2.19516222038122 0.0210064909867453 no 3248 0.014075981626101 4723 5412760 SGTC_700 3453-2283 142 µM -2.203728314971 0.0205846026910583 no 3249 0.0137717283019399 4741 565664 SGTC_3103 9120822 49.47 µM -2.2086502901822 0.0203454537758714 no 3250 0.0135994872525466 4714 17141819 SGTC_208 k072-0098 12.366 µM -2.21292726381723 0.020139560537967 no 3251 0.0134513303498645 4737 5948901 SGTC_3145 9085516 49.47 µM -2.21333682436867 0.0201199373511934 no 3252 0.0134372163171442 4696 25236195 SGTC_135 0933-0004 26.348 µM -2.21480744733639 0.0200496093045064 no 3253 0.0133866419189043 4673 21230617 YGL099W LSG1 SGTC_660 4031-1742 102 µM -2.21658687860896 0.0199647923441129 no 3254 0.0133256675187799 4635 6738706 SGTC_2127 5253358 187.912 µM -2.22032761092452 0.0197874818184383 no 3255 0.0131982684852061 4685 20612 SGTC_3326 9140064 16.379 µM -2.22395508090048 0.0196168182252408 no 3256 0.0130757332953122 4691 1868434 SGTC_1191 1487-1166 10.6 µM -2.24097649251542 0.0188326015458086 no 3257 0.0125137988755993 4728 3955771 SGTC_2963 9082507 9 µM -2.25224995050933 0.0183280228815276 no 3258 0.0121532405238992 4708 16459611 SGTC_3010 9080089 71.4286 µM -2.28106049415884 0.0170905691745214 no 3259 0.0112724337198993 4737 17027233 SGTC_272 doxorubicin 8.13 µM -2.33499327469381 0.0149653490777012 no 3260 0.00977188603551777 4750 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_223 busulfan 5 mM -2.33612277686862 0.0149233865887577 no 3261 0.0097424217662174 4754 2478 A DNA alkylator. SGTC_2426 5582046 32.21 µM -2.33662846640878 0.0149046323655355 no 3262 0.00972925548753583 4726 2251934 SGTC_845 0330-0138 4.51 µM -2.3418692736262 0.0147114597561892 no 3263 0.00959371711920365 4722 9039800 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.34488104434827 0.0146014254095486 no 3264 0.00951657549090078 4740 4000243 SGTC_811 0416-0114 265 µM -2.35882599755584 0.0141011334234134 no 3265 0.00916642479092523 4748 6612453 SGTC_2166 5933061 31.504 µM -2.35906950214794 0.0140925302826999 no 3266 0.00916041205402537 4691 2877375 SGTC_3132 9126706 49.47 µM -2.36991406045081 0.0137139456766811 no 3267 0.00889611016608498 4744 850858 SGTC_2079 5212404 121 µM -2.39121356931665 0.0129958593395861 no 3268 0.00839639066685185 4723 758462 SGTC_2322 7413319 38.22 µM -2.41016699770806 0.0123844355152439 no 3269 0.00797261003020268 4688 1840400 SGTC_268 camptothecin 39.6153 µM -2.4154833980064 0.0122174715913112 no 3270 0.00785716942637151 4715 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1657 st012939 43.4 µM -2.41736870127761 0.0121587331323407 no 3271 0.00781658644785686 4759 24207257 SGTC_1137 ixabepilone 100 µM -2.44717469618485 0.011262109500356 no 3272 0.00719905163867167 4719 154225 A novel microtubule stabilizer. SGTC_1453 4237-0541 195 µM -2.45287284272141 0.0110974020992018 no 3273 0.00708602130399643 4758 739892 SGTC_1269 0831-0796 3.05 µM -2.46031249651926 0.0108855115098768 no 3274 0.00694080434399224 4752 927758 SGTC_429 1112-0049 25.5 µM -2.46678934084691 0.0107039186810569 no 3275 0.00681652678454778 4725 2836170 SGTC_2164 5685496 200 µM -2.4737197049145 0.0105125374000848 no 3276 0.00668572794077428 4749 759046 SGTC_2622 2-methoxyxanthone 59.94 µM -2.48464940737442 0.0102167728703132 no 3277 0.00648395391056612 4743 71034 A hepatoprotective. SGTC_1655 st012546 55.1 µM -2.49726925735854 0.00988432324529782 no 3278 0.00625769430070252 4757 720985 YLR208W SEC13 SGTC_870 0573-2213 57.6 µM -2.50520905600118 0.00968003735752735 no 3279 0.00611895178536309 4765 3916321 SGTC_2916 7875993 68.79 µM -2.50803789455837 0.00960814976157906 no 3280 0.00607018233461734 4719 1299250 SGTC_2823 7987624 58.44 µM -2.50902297771403 0.00958322619377284 no 3281 0.00605328044772907 4705 2239440 SGTC_1941 st076221 61.8 µM -2.51494880004423 0.0094344862760377 no 3282 0.00595248356503887 4696 2828568 SGTC_2519 cryptotanshinone 88.04 µM -2.52154504368773 0.00927129677243742 no 3283 0.00584203576715556 4758 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1561 5-methoxyflavone 52.9 µM -2.53173381388238 0.00902408285555223 no 3284 0.0056750058761692 4763 94525 SGTC_1299 1079-1439 3.74 µM -2.53177162951757 0.00902317618010737 no 3285 0.00567439392440019 4766 323161 SGTC_1921 5740136 50 µM -2.53831024639128 0.00886759960671369 no 3286 0.00556945948277219 4728 1774243 SGTC_3175 9106517 49.47 µM -2.54187242704143 0.00878383603991901 no 3287 0.00551302047602534 4762 41468073 SGTC_627 1391-0720 175 µM -2.54218838383691 0.00877644001206286 no 3288 0.00550803909244666 4763 997839 SGTC_894 0960-0238 55.9 µM -2.55243458089462 0.00853953406592538 no 3289 0.00534864981763337 4762 6741907 YDL195W SEC31 SGTC_49 0717-0965 32.132 µM -2.5568316515729 0.00843960065236419 no 3290 0.0052815162230854 4770 5889349 YGL099W LSG1 SGTC_2528 xanthyletin 44.79 µM -2.56442043727625 0.00826954126765621 no 3291 0.00516741353653433 4759 65188 An natural product with antifungal activity of unknown mechanism. SGTC_43 0570-0105 72.5 µM -2.56595528712579 0.00823551460662809 no 3292 0.00514460453031271 4738 1114046 YDL195W SEC31 SGTC_966 1300-0360 30.2 µM -2.57350589415356 0.00806990694671094 no 3293 0.00503369660409069 4767 70588 SGTC_2753 fluvastatin 17.09 µM -2.58453967220403 0.00783316767694098 no 3294 0.00487545429589321 4741 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_953 1188-0045 9.7 µM -2.60692232189106 0.0073716240831998 no 3295 0.00456800416466319 4738 6144426 SGTC_1360 1598-0022 39.8 µM -2.61330510650734 0.00724447736276887 no 3296 0.00448356052930522 4780 761525 SGTC_1796 st049173 110.4 µM -2.61472103573226 0.00721653517301994 no 3297 0.00446501792394553 4766 94134 SGTC_248 streptozotocin 5.23457 mM -2.62993930391941 0.00692216344055454 no 3298 0.00427000569804245 4783 5300 DNA alkylating agent. SGTC_1562 morin hydrate 59.1 µM -2.63456732128644 0.00683476986519468 no 3299 0.00421222979144564 4768 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2603 homopterocarpin 100 µM -2.66280993343808 0.00632226607143385 no 3300 0.00387455852370671 4747 101795 A weak amylase inhibitor. SGTC_2981 9013952 38.96 µM -2.6629814498719 0.00631926050739972 no 3301 0.00387258418437262 4730 2996344 SGTC_1170 0310-0127 64.8 µM -2.66998035881368 0.00619768919137743 no 3302 0.00379278420216539 4770 774975 SGTC_513 4245-1575 41.7 µM -2.68730483747161 0.00590562894312009 no 3303 0.00360155908914529 4657 719745 SGTC_2724 maprotiline 69.64 µM -2.7587115511768 0.00482662800340171 no 3304 0.00290148656755093 4758 4011 A tricyclic antidepressant. SGTC_251 melphalan 456.522 µM -2.76195537960324 0.0047820798863263 no 3305 0.00287281650466782 4786 460612 A DNA alkylator. SGTC_1347 1493-0251 600 nM -2.76516325166026 0.00473838648501697 no 3306 0.00284471572413706 4785 3986378 SGTC_111 0083-0039 52.457 µM -2.78635563098188 0.00445857098553194 no 3307 0.0026652178038505 4778 759313 SGTC_3204 9114183 49.47 µM -2.78993343129996 0.004412815499968 no 3308 0.00263594398474649 4741 17027248 SGTC_2970 9090938 41.86 µM -2.79469225403866 0.00435260647334504 no 3309 0.00259745708305491 4784 17217104 SGTC_275 trichlorophene 5.69 µM -2.79817480773818 0.00430901124685228 no 3310 0.00256961452286029 4790 62616 SGTC_2342 7990637 118.86 µM -2.81365871429281 0.00411987003402975 no 3311 0.00244905999459565 4763 2033102 YER133W GLC7 SGTC_3089 9117425 49.47 µM -2.82152189902964 0.00402669220602144 no 3312 0.00238981870484587 4775 9401657 SGTC_3265 9137266 49.47 µM -2.89645422513956 0.00322904501696547 no 3313 0.00188702848410639 4778 17224265 SGTC_897 1000-0139 31.4 µM -2.90519574857416 0.00314592313746942 no 3314 0.00183511741567488 4775 6151020 SGTC_1815 st051655 58.2 µM -2.94708994318754 0.00277368376385358 no 3315 0.0016038994239642 4790 5984156 SGTC_871 0574-0004 149 µM -2.95348258415821 0.00272051920201967 no 3316 0.00157105168788555 4767 9551173 SGTC_3018 9082602 49.47 µM -2.96368042132586 0.00263761074133988 no 3317 0.00151991901200889 4719 17332089 SGTC_617 3770-0098 35 µM -2.97321956802941 0.00256213059443254 no 3318 0.00147346779268237 4764 5962639 SGTC_2 0422-0095 29 µM -2.97952037312854 0.00251335072708913 no 3319 0.00144350015476391 4730 6790840 SGTC_2568 diosmetin 100 µM -2.99578452796367 0.00239129347755808 no 3320 0.00136869894066162 4786 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1329 1447-1697 50.6 µM -3.00057445915291 0.002356383416159 no 3321 0.00134735430841271 4796 2840515 SGTC_227 fluconazole 33.516 µM -3.08342805757418 0.0018211951242125 no 3322 0.00102315290184249 4797 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_310 1273-0058 1.06 µM -3.09215150706916 0.0017718232354735 no 3323 0.000993557006513449 4513 2734232 SGTC_83 0170-0301 39.027 µM -3.09712786711366 0.00174420718615595 no 3324 0.000977027833052879 4797 3089716 SGTC_3219 9131112 49.47 µM -3.1083553955452 0.00168333388999679 no 3325 0.000940658428011261 4738 17612988 YMR079W SEC14 SGTC_266 formosanin C 406 nM -3.17159308606521 0.00137516919083303 no 3326 0.000758026358379196 4761 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1998 st075797 76.8 µM -3.19147978750825 0.00128948954377823 no 3327 0.000707730071919883 4797 24208315 SGTC_2976 9009005 19.48 µM -3.224651012105 0.00115736989812094 no 3328 0.000630631585590849 4785 2993148 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -3.23418190051372 0.00112177023657254 no 3329 0.000609958657032084 4791 1377 SGTC_2848 9016370 25.97 µM -3.2584072780272 0.00103575310010251 no 3330 0.000560197413894466 4775 7894410 SGTC_4 0960-0234 25.671 µM -3.31688782399197 0.000852447752069286 yes 3331 0.000455130779249924 4736 6821112 SGTC_453 enantio-paf c16 10 µM -3.34323057234691 0.000780056439048684 yes 3332 0.000414045316993286 4469 13871343 A lipid and platelet activating factor SGTC_304 1310-0298 97 µM -3.35638238635344 0.000746073672635278 yes 3333 0.000394846505398642 4697 1550234 SGTC_110 0850-0284 111.64 µM -3.42197469620372 0.000596059409565172 yes 3334 0.000310840494942208 4804 3906265 SGTC_1813 st051246 8.6015 µM -3.42543801221478 0.000588972234557639 yes 3335 0.000306904490849102 4801 5291959 SGTC_2308 7584454 197.62 µM -3.44527916198436 0.00054984897291886 yes 3336 0.000285234949352283 4782 893577 SGTC_805 3852-0218 479 µM -3.45596591620756 0.000529786258326775 yes 3337 0.000274162325481096 4802 6615355 SGTC_1673 st016611 27.3 µM -3.48728747568454 0.000474819868809353 yes 3338 0.000243973278911385 4793 5226799 SGTC_960 1222-0186 7.7 µM -3.50606430461489 0.000444451794319223 yes 3339 0.000227392665798387 4797 3126296 SGTC_3174 9107204 49.47 µM -3.5332832641521 0.00040361540518543 yes 3340 0.00020521623049336 4799 3938802 SGTC_455 paf C-16 10 µM -3.63304615527739 0.000281870302970496 yes 3341 0.00014004744596795 4791 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1915 st067105 30.6 µM -3.65817271564532 0.000257133150524171 yes 3342 0.0001270099251381 4794 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3143 9086658 49.47 µM -3.73735598684653 0.000191781990683277 yes 3343 9.29827704975722e-05 4785 25236626 SGTC_44 0929-0055 61.211 µM -3.80918151473904 0.000146263900813187 yes 3344 6.97137877501367e-05 4716 1379590 SGTC_1731 st035964 63 µM -3.86673741391601 0.00011731756178603 yes 3345 5.5150540636703e-05 4790 6739575 SGTC_1635 st007035 42.4 µM -4.04739665737924 5.7565595317621e-05 yes 3346 2.58952176484408e-05 4791 3716403 SGTC_1707 st032323 6.317 µM -4.06268530553113 5.41250149329431e-05 yes 3347 2.42557049408494e-05 4784 3132057 YMR211W DML1 SGTC_3000 9075062 71.4286 µM -4.06701385988308 5.31867302725412e-05 yes 3348 2.38097059467676e-05 4803 17057871 SGTC_1718 roemerine 11.9335 µM -4.10608780875047 4.5384353779473e-05 yes 3349 2.01208279703919e-05 4686 235224 An aporphine alkaloid with mutagenic activity. SGTC_1451 4152-0210 104 µM -4.10745998308135 4.51310630246662e-05 yes 3350 2.00017029017824e-05 4809 659563 SGTC_1925 st057770 10.1 µM -4.11492765366021 4.37758446132429e-05 yes 3351 1.93650435254948e-05 4807 5989122 SGTC_1908 st060353 56.5 µM -4.34589635148006 1.66211028044349e-05 yes 3352 6.93540300556884e-06 4804 4227716 SGTC_2306 7482397 179.52 µM -5.0797402735462 5.51674439920047e-07 yes 3353 1.88975615126643e-07 4806 891448 SGTC_255 tunicamycin 200.472 nM -5.31865245069027 1.6333286586099e-07 yes 3354 5.2269303407247e-08 4808 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3266 9136860 49.47 µM -5.35660799410203 1.33953950145518e-07 yes 3355 4.23994119077561e-08 4777 4871271 YPR165W RHO1 SGTC_457 grayanotoxin iii 135 µM -7.33371397377577 6.68153603981961e-13 yes 3356 1.11930302825051e-13 4808 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.