SGTCid condition conc unit YOR316C-A|YOR316C-A.score YOR316C-A|YOR316C-A.strain.pval YOR316C-A|YOR316C-A.strain.significant YOR316C-A|YOR316C-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1255 0566-0045 221 µM 5.37040002535477 3.06548772038425e-09 yes 1 3.92810886504532e-08 8 2788469 SGTC_566 0958-0068 16.5 µM 5.29495287627958 4.96640168232734e-09 yes 2 5.95235529085979e-08 7 6815365 SGTC_2073 5212005 126 µM 5.10406685045612 1.63577430444333e-08 yes 3 1.66215376519489e-07 2 691789 SGTC_945 3381-0768 11.3 µM 4.91385675825162 5.15004879072083e-08 yes 4 4.46510027771288e-07 15 1126236 YIL048W NEO1 SGTC_2770 toltrazuril 17.5 µM 4.72932470222711 1.50702083891272e-07 yes 5 1.12633930624479e-06 9 68591 Kills coccidiodes. SGTC_236 1509-0011 5.31 µM 4.63555009106342 2.56279367820867e-07 yes 6 1.77994751173114e-06 349 3107280 SGTC_1256 0570-0116 285 µM 4.49753299682925 5.49925149030316e-07 yes 7 3.43732471371992e-06 8 410638 SGTC_623 k072-0108 16.9 µM 4.4412378829366 7.46261351995327e-07 yes 8 4.47214251990202e-06 7 5382803 SGTC_2759 disulfiram 3.38 µM 4.26053089375523 1.94126846384961e-06 yes 9 1.01970944223336e-05 19 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_773 4358-1457 44.6 µM 4.14766982914269 3.46223338659634e-06 yes 10 1.67938152943359e-05 39 1186886 SGTC_634 1611-4317 11.2 µM 4.0212452726269 6.50876530803689e-06 yes 11 2.89456438020976e-05 14 2843522 SGTC_2520 obtusaquinone 4.71 µM 3.71942452105314 2.73380172480652e-05 yes 12 9.98386024335198e-05 25 5967872 SGTC_2808 7946468 45.46 µM 3.39723592506754 0.000113182711749369 yes 13 0.00034035126197093 48 2970879 SGTC_2167 5876490 200 µM 3.3195129666574 0.000156744422821022 yes 14 0.000450873084259788 58 686534 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 3.27549826568973 0.000187930474894022 yes 15 0.000527378809862264 40 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2807 7945238 51.95 µM 3.24746351032652 0.000210722386811229 yes 16 0.000582192968173071 64 17148797 SGTC_1624 st003710 6.25 µM 3.17896752878421 0.000277716414412258 yes 17 0.000739003237147876 77 24207033 SGTC_2763 lisinopril 49.32 µM 3.1623617812204 0.000296709593743912 yes 18 0.000782475037317507 28 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1940 st075990 51.1 µM 3.14831337766698 0.000313714746496225 yes 19 0.000821077710812588 55 1084979 SGTC_1115 galangin 695.678 nM 3.11519041682 0.000357462501932426 yes 20 0.000919130998334529 46 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2246 7293507 91.5585 µM 3.07592301830773 0.000416648544047196 yes 21 0.00104926008897023 76 887656 SGTC_2935 9038016 29.96 µM 3.0694404330884 0.000427252417635121 yes 22 0.00107230083965723 57 6463195 SGTC_568 1193-0097 7.48 µM 3.03053682678615 0.00049632766825185 yes 23 0.00122059707296743 218 3646150 SGTC_939 1165-0479 45.3 µM 2.96890503261216 0.000627208127039647 yes 24 0.00149431472637738 95 1377347 SGTC_734 2023-0417 80 µM 2.95426994486537 0.000662650399507408 yes 25 0.0015670486415763 77 3935732 SGTC_1260 0700-1617 7.75 µM 2.93988418915623 0.000699281615415047 yes 26 0.00164167471264143 89 2853078 SGTC_782 0083-0095 30.5 µM 2.91761645963947 0.000759679828381407 yes 27 0.00176358953035709 81 3591729 An indicator and reagent. SGTC_1635 st007035 42.4 µM 2.9093415908573 0.000783323157908376 yes 28 0.00181095441666902 304 3716403 SGTC_213 1246-0773 967 nM 2.85724456451896 0.000948419514387195 yes 29 0.0021366821720043 80 6251622 SGTC_1071 trifluoperazine 6.31 µM 2.82347931253791 0.00107189375059088 no 30 0.002375274581966 76 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1948 st076329 66.6 µM 2.78872637169099 0.00121422397407705 no 31 0.00264578760774947 98 24208413 SGTC_3124 9127567 49.47 µM 2.78668699223641 0.00122309072987746 no 32 0.00266249429744069 65 17592030 SGTC_1278 0874-0585 172 µM 2.78280813654586 0.00124011882334522 no 33 0.00269453322554358 68 766306 SGTC_2797 7859098 81.82 µM 2.78220735505218 0.00124277555625008 no 34 0.00269952663127199 93 972681 SGTC_609 0986-0026 86.3 µM 2.78042143909265 0.00125070388292743 no 35 0.00271441967409761 103 2848610 SGTC_2620 irigenin 100 µM 2.76109420116447 0.00133951355737714 no 36 0.00288040287922245 108 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_865 0488-0499 301 µM 2.75168666068015 0.00138479459084885 no 37 0.00296446100373753 65 9634651 SGTC_889 0919-1524 82.7 µM 2.73357548285506 0.0014759269094652 no 38 0.00313253806800711 68 3905452 SGTC_2341 7987486 176.74 µM 2.70566097262599 0.00162714515018448 no 39 0.00340843003971 91 1258686 SGTC_1428 4049-0204 61.7 µM 2.70027197012596 0.00165791542947257 no 40 0.00346414066046455 79 X1428 SGTC_1167 k781-0610 148 µM 2.6920585511502 0.00170583304124726 no 41 0.00355062385295107 100 4525169 SGTC_1606 st000094 49.2 µM 2.68229575058966 0.0017644279785838 no 42 0.00365593931356602 86 1242210 SGTC_375 3970-0961 9.27 µM 2.68200978334418 0.00176617159346592 no 43 0.00365906597885333 98 2898222 SGTC_3195 9113082 49.47 µM 2.67081791743215 0.00183565492605643 no 44 0.00378333399067679 74 17018038 SGTC_704 1310-0270 142 µM 2.61975566434767 0.0021852821348155 no 45 0.00439963936260064 121 5718033 SGTC_127 0180-0333 59.125 µM 2.60570192086053 0.00229157193384253 no 46 0.00458431068725101 163 771601 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.60320233081692 0.00231095976088923 no 47 0.004617871515109 159 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_807 1315-0151 48 µM 2.59440170349765 0.00238040883480018 no 48 0.00473778521983649 116 4011080 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.56984555724986 0.00258429186051192 no 49 0.00508719314809799 117 3256 An antibiotic and ribosome inhibitor. SGTC_777 1315-0167 517 µM 2.53401034804463 0.00291019148663642 no 50 0.00563827008161845 100 4221767 SGTC_2074 5212007 75.395 µM 2.49071458146526 0.00335308725840712 no 51 0.00637432434553497 87 758611 SGTC_699 0375-0592 111 µM 2.48814817846443 0.00338114991851992 no 52 0.00642051092103504 101 762578 SGTC_2752 diclazuril 33.15 µM 2.44756924191903 0.00385380983388301 no 53 0.00719117436561817 276 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1201 1889-3372 45.9 µM 2.43795622199534 0.00397411577477752 no 54 0.00738528133784828 82 5392199 SGTC_1078 idebenone 36.1 µM 2.43609741099679 0.00399776294951984 no 55 0.00742334288989204 182 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_38 0929-0051 58.268 µM 2.41011770831691 0.00434170956830839 no 56 0.00797368724331522 141 1379719 SGTC_950 1165-0508 94.1 µM 2.39103475381143 0.0046109524491658 no 57 0.00840048121373061 143 6148369 SGTC_1001 4048-4355 44.4 µM 2.38930494941525 0.00463607999694819 no 58 0.00844014226817766 145 21824233 SGTC_628 1636-0253 16 µM 2.38545784753983 0.00469240246246361 no 59 0.00852893855003951 166 4456143 SGTC_53 0973-0023 39.979 µM 2.3715449244117 0.00490122062643375 no 60 0.00885694655580671 125 674768 SGTC_89 0302-0250 142.109 µM 2.36845348171391 0.00494872937485052 no 61 0.00893131326223534 146 4203518 YLR208W SEC13 SGTC_3202 9113761 49.47 µM 2.35982491318588 0.00508350957230359 no 62 0.00914178103213973 197 4798415 SGTC_781 4335-2806 94.4 µM 2.35702580595379 0.00512792903802158 no 63 0.00921098330227175 136 845254 SGTC_769 0302-0231 76 µM 2.34538306448307 0.00531641887138045 no 64 0.00950376992943898 220 571869 YER009W NTF2 SGTC_1211 1056-0033 32.3 µM 2.33115715524172 0.00555507560463183 no 65 0.00987253720659141 104 6741922 SGTC_2488 5268135 45.7 µM 2.30645374984144 0.00599218777912131 no 66 0.0105426457959953 200 1270356 YLR208W SEC13 SGTC_718 1130-0073 349 µM 2.28055471334454 0.0064829393107189 no 67 0.0112874048434789 147 6740020 SGTC_1088 bifonazole 369 nM 2.27684666814536 0.00655603639379262 no 68 0.0113976917891052 132 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2518 prenyletin 46.28 µM 2.27079851697252 0.00667682889315391 no 69 0.0115795888895149 82 3873459 A coumarin with calcium channel inhibitory activity. SGTC_559 1550-0661 158 µM 2.26935145334717 0.00670601937587264 no 70 0.0116234809437258 134 5830875 SGTC_1186 1319-0216 26 µM 2.26859934068388 0.00672123565471997 no 71 0.0116463508753751 163 4565136 SGTC_280 3448-3607 3.04 µM 2.22563891012459 0.0076426308957665 no 72 0.0130191888553728 103 626179 SGTC_542 3381-0244 89.3 µM 2.2201531465388 0.00776795232384294 no 73 0.0132041867803773 195 1112843 SGTC_2625 euphol 100 µM 2.20818214665064 0.00804772373891629 no 74 0.0136157892125402 192 6708538 A triterpene alcohol. SGTC_2337 9009472 200 µM 2.2034611781473 0.00816046853468553 no 75 0.0137811301620165 215 5742383 SGTC_651 3253-0966 34.4 µM 2.16770180066606 0.00906046482838784 no 76 0.0150906911937753 188 781462 SGTC_626 0214-0009 33 µM 2.1656936616838 0.00911348932850346 no 77 0.0151673018552747 167 3437874 SGTC_1365 1672-3266 55.4 µM 2.14381403158698 0.00970905597179232 no 78 0.0160238952970872 176 6415873 SGTC_713 1488-1073 324 µM 2.13966176758481 0.00982584274714784 no 79 0.0161910554639124 133 3312542 SGTC_285 1486-1325 46 µM 2.11042707566562 0.0106833756844992 no 80 0.017410793176825 191 22310230 SGTC_2859 9028643 45.46 µM 2.10915924783275 0.0107219953783406 no 81 0.0174654190944853 137 17151580 SGTC_1521 st012942 49.4 µM 2.10865700506667 0.0107373279334997 no 82 0.0174870992719178 218 24207259 SGTC_1338 1486-1223 76 µM 2.08930853019405 0.0113427175109457 no 83 0.0183399795104066 195 3444526 SGTC_648 0375-0473 33.3 µM 2.07325336677018 0.0118673682475722 no 84 0.0190743530745764 216 1713139 SGTC_57 miconazole 162.5 nM 2.06573696929871 0.0121201403352694 no 85 0.0194266612573432 195 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1236 0330-0013 258 µM 2.05933760610507 0.0123390124736965 no 86 0.0197309541654672 166 4617066 SGTC_1149 3909-7961 23.3 µM 2.0582964289218 0.0123749449579105 no 87 0.0197808433938948 205 735261 SGTC_2476 5806916 10.51 µM 2.05816547860134 0.0123794706473832 no 88 0.0197871256059578 167 2870194 SGTC_1579 chlormadinone acetate 49.4 µM 2.05088359827185 0.0126334017397716 no 89 0.0201391418909676 193 45114258 A steroidal progestin. SGTC_1384 3089-0840 101 µM 2.04945090004665 0.0126838895624405 no 90 0.0202090221842438 176 1069836 SGTC_56 0957-0365 83.25 µM 2.03010036051381 0.0133830898480855 no 91 0.0211731694493664 243 6752360 SGTC_1411 3909-8223 150 µM 2.01894335726442 0.0138011674356333 no 92 0.0217465535550273 192 X1411 SGTC_386 1509-0011 3.07 µM 2.01884820497152 0.0138047809052638 no 93 0.0217514995100315 350 3107280 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.01002498042575 0.0141434138267513 no 94 0.0222142725177801 243 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1171 0368-0077 21.4 µM 2.00520027338434 0.0143315939706319 no 95 0.0224708204381909 186 3239779 SGTC_2515 chrysin 20.77 µM 1.99232978605179 0.0148441684284479 no 96 0.023167442816346 193 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_290 2043-6722 48.1 µM 1.97753936248313 0.0154525989907166 no 97 0.0239903478682728 210 773758 YLR208W SEC13 SGTC_462 ag-879 158 µM 1.97481199915381 0.0155671013155129 no 98 0.0241447434180617 259 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2787 5284540 71.43 µM 1.94884543603629 0.0166941964443818 no 99 0.0256569429193336 245 736958 SGTC_3162 9099653 49.47 µM 1.94468117013571 0.0168812949695689 no 100 0.02590668159859 168 25237511 SGTC_1340 1486-1359 257 µM 1.93124696175108 0.017497158679312 no 101 0.0267262594777075 235 4309068 SGTC_470 aa-861 153 µM 1.90755744549605 0.0186299259014095 no 102 0.0282242198260333 299 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_100 0086-0128 49.5915 µM 1.89902897613414 0.0190527393524671 no 103 0.0287803331391672 321 93297 SGTC_876 0720-0963 56.8 µM 1.89851101933156 0.0190786786938009 no 104 0.028814398790688 235 765861 SGTC_217 ketoconazole 989 nM 1.89388730337221 0.0193115682957622 no 105 0.0291199850612497 264 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_967 1306-0166 352 µM 1.8852103772203 0.0197551357741935 no 106 0.0297007201730869 271 4437607 SGTC_1795 st049545 62.3 µM 1.87299615428029 0.0203941652738652 no 107 0.030534458023236 220 5291882 SGTC_1400 3771-8998 51.5 µM 1.86979408571002 0.0205645622899498 no 108 0.0307562089934249 190 670767 SGTC_2354 9060492 162 µM 1.86175403272414 0.0209977347968648 no 109 0.0313188842663699 287 6471895 SGTC_1325 1431-0015 227 µM 1.85867180253406 0.0211658308544472 no 110 0.0315368363182054 242 1103340 SGTC_185 k048-0037 25.491 µM 1.85774560410178 0.0212165649705946 no 111 0.0316025745232056 225 6827589 SGTC_759 3486-0358 89.3 µM 1.85639704809146 0.0212906183376622 no 112 0.0316984925917338 279 875103 SGTC_1647 st011722 22.4 µM 1.85322500244926 0.0214656672963646 no 113 0.0319250577304882 240 2854783 SGTC_662 k832-1615 104 µM 1.85175147839762 0.021547396476733 no 114 0.0320307590600237 257 5878478 SGTC_1977 st070720 65.3 µM 1.85106629131383 0.0215854899434082 no 115 0.0320800084017129 225 682188 SGTC_1225 1216-0074 20.6 µM 1.84597394618698 0.0218703895880077 no 116 0.0324479942564823 256 4241466 SGTC_341 1486-1430 230 µM 1.84296947593651 0.0220399643697773 no 117 0.0326667336343795 280 2054753 YPL210C SRP72 SGTC_671 0560-0003 407 µM 1.83665482004087 0.0223999887385186 no 118 0.0331304344742127 246 3238678 SGTC_2158 5657123 3.6195 µM 1.80729314402126 0.0241398206240152 no 119 0.0353582922275989 240 2858827 SGTC_1054 3429-0080 167 µM 1.80184123755606 0.024475062208098 no 120 0.0357851938204367 314 1162877 SGTC_684 1140-0066 328 µM 1.79038687639137 0.0251921408662598 no 121 0.0366958692980166 340 6813534 SGTC_705 1124-0212 310 µM 1.78886153584562 0.0252889472348529 no 122 0.0368185588569196 308 9554485 SGTC_892 0929-0076 29 µM 1.78507461206043 0.0255306340766531 no 123 0.0371246076766993 356 5751038 SGTC_1086 cerivastatin 2.18 µM 1.78459751731829 0.0255612196802492 no 124 0.0371633122083705 237 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2989 9073649 71.4286 µM 1.7831926397503 0.025651461849599 no 125 0.0372774750949695 385 21367202 SGTC_156 3474-0145 5.642 µM 1.78189254683456 0.0257352106508793 no 126 0.0373833780955429 310 2265471 SGTC_631 k072-0230 41.5 µM 1.78088089552912 0.0258005369704626 no 127 0.0374659551181293 302 5773147 SGTC_3260 9137109 49.47 µM 1.78038488259108 0.0258326171505648 no 128 0.037506497048542 198 17478346 SGTC_803 4488-1585 147 µM 1.77623960316744 0.0261020249353198 no 129 0.0378467166432571 257 747204 SGTC_1176 0848-0131 83.3 µM 1.76821992531607 0.0266299077442678 no 130 0.0385120721982567 320 6769040 SGTC_2125 5246583 200 µM 1.75802209262993 0.0273140155803892 no 131 0.0393718751631432 370 835267 SGTC_3211 9128781 49.47 µM 1.75798534235502 0.0273165071830661 no 132 0.0393750016771179 344 17194361 SGTC_2175 5807670 165.306 µM 1.75742343862724 0.0273546268610581 no 133 0.0394228305582322 277 241186 SGTC_2928 9011484 9.79 µM 1.75393099816938 0.0275925508510032 no 134 0.0397211656488448 274 2994751 SGTC_1607 st000305 50.6 µM 1.74704741698689 0.0280665495878522 no 135 0.0403145566990348 311 5457690 SGTC_1048 3161-0300 24.5 µM 1.74675765944268 0.028086649896406 no 136 0.0403396919618638 323 2165101 SGTC_882 0843-0131 351 µM 1.74046000781479 0.028526484030006 no 137 0.0408891382604337 318 5425421 SGTC_3336 9143619 71.43 µM 1.73509659038529 0.0289055741976049 no 138 0.0413618490724425 331 45595730 SGTC_1371 2421-0008 32.7 µM 1.73507744145753 0.0289069351226985 no 139 0.0413635446860962 349 2827552 SGTC_3199 9111318 49.47 µM 1.73367472496957 0.0290067719143515 no 140 0.0414879067792566 309 8548020 SGTC_169 k015-0017 16.025 µM 1.73349927763203 0.0290192793214011 no 141 0.0415034828911341 272 1840002 SGTC_1530 rhein 70.4 µM 1.72906244091763 0.02933706820273 no 142 0.0418989601745874 325 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2533 agelasine 13.65 µM 1.72458731966071 0.0296605213115488 no 143 0.0423009351208192 350 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.72452802358345 0.0296648269036606 no 144 0.0423062822244595 303 75037 A free radical scavenger. SGTC_2088 5278280 127.392 µM 1.71341338240355 0.0304810897391228 no 145 0.0433182580213506 349 791502 SGTC_2717 st081029 62.2815 µM 1.71287681982108 0.0305209612714383 no 146 0.043367601796743 266 5292846 SGTC_1251 0490-5699 265 µM 1.71151004416903 0.0306227204849838 no 147 0.0434934993049627 373 3883818 SGTC_1791 st048313 56.1 µM 1.70673353434112 0.0309805503919605 no 148 0.0439357956162729 269 1204976 SGTC_563 tetrahydrosecaminediol 614 µM 1.70368427158039 0.031210788834501 no 149 0.0442200440513315 336 334274 A psychoactive constituent of the cannabis plant. SGTC_2820 7989630 71.43 µM 1.6995417982693 0.0315258371385717 no 150 0.0446085729950869 248 2984098 SGTC_456 gingerol 170 µM 1.69801654906044 0.0316424973534021 no 151 0.044752319217504 321 442793 A herb. SGTC_365 0121-0052 13.6 µM 1.69750308534745 0.0316818503138292 no 152 0.0448007941423057 432 3101739 SGTC_330 1488-0319 80.1 µM 1.69120087121953 0.0321681683164542 no 153 0.0453992223410981 310 6846614 SGTC_99 0109-0120 622.8 µM 1.69075020645564 0.0322031792165088 no 154 0.0454422604549533 282 759414 SGTC_1091 telmisartan 47.6 µM 1.69037783052507 0.0322321317995551 no 155 0.0454778468013918 331 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_284 0988-0104 32.6 µM 1.68280737594141 0.0328254152314433 no 156 0.0462061933493304 315 4666532 SGTC_1345 1488-0192 31.4 µM 1.68259131752797 0.032842478607601 no 157 0.0462271168242038 331 658348 SGTC_342 k048-0088 23.3 µM 1.68242428416613 0.0328556752041514 no 158 0.046243297841493 328 6820570 SGTC_897 1000-0139 31.4 µM 1.6821022016205 0.0328811339185002 no 159 0.0462745117734144 314 6151020 SGTC_3248 9135562 49.47 µM 1.67231828932814 0.0336622764991365 no 160 0.0472307875180461 344 17650701 SGTC_31 0508-1974 57.237 µM 1.66355416924342 0.0343749061166281 no 161 0.0481007785818518 322 6810525 SGTC_1657 st012939 43.4 µM 1.66292699308525 0.0344263749603605 no 162 0.0481635251782278 288 24207257 SGTC_1558 st069300 45.6 µM 1.65911661212805 0.0347404342220464 no 163 0.0485461482158132 242 24208000 SGTC_1687 st020778 55.3625 µM 1.65237277787705 0.0353020394849291 no 164 0.0492292906921081 523 4259299 SGTC_1798 st045719 60.953 µM 1.6479112064621 0.0356776619182944 no 165 0.0496854467197244 283 3980186 SGTC_1042 0350-0096 82 µM 1.64326740457706 0.0360720991943045 no 166 0.0501638095968939 341 3122515 SGTC_2565 isoliquiritigenin 100 µM 1.64283923395726 0.0361086464594557 no 167 0.0502081001380062 289 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_694 1315-0438 43.2 µM 1.64204169990148 0.0361768022380685 no 168 0.0502906812267926 282 6793154 SGTC_2458 5808907 16.39 µM 1.6389247191502 0.036444184605074 no 169 0.0506144694517441 310 2731747 SGTC_1162 k048-0130 20.1 µM 1.63565078262747 0.0367267702416448 no 170 0.0509563478103708 344 6797406 SGTC_1235 benzylparaben 21.5 µM 1.62827758282028 0.0373697438289113 no 171 0.0517330202921071 334 7180 SGTC_1004 4084-0029 199 µM 1.62692648513493 0.0374885561562396 no 172 0.0518763560797592 379 716894 YLR208W SEC13 SGTC_620 0109-0052 432 µM 1.6246649942757 0.0376881164857517 no 173 0.0521169800607864 349 493037 SGTC_1023 4482-3888 16 µM 1.6206581711844 0.0380438187203726 no 174 0.0525454845492938 343 3303168 SGTC_506 n9-isopropylolomoucine 153 µM 1.61924525321954 0.0381699005317961 no 175 0.0526972524144471 341 6610355 SGTC_474 dl-dihydrosphingosine 5 µM 1.61787979658938 0.0382920707218595 no 176 0.052844252541103 371 3058739 A sphingolipid protein kinase C inhibitor. SGTC_979 1426-2828 121 µM 1.61695368864572 0.0383751127988651 no 177 0.0529441389732987 403 747872 SGTC_33 0986-0033 35.816 µM 1.61039085611167 0.0389678027139076 no 178 0.0536562777627266 311 2848082 SGTC_2000 st075254 36.4 µM 1.6077642652417 0.0392070893874792 no 179 0.0539434087928777 306 17234175 SGTC_1156 4092-0367 4.88 µM 1.6075972896931 0.0392223414701735 no 180 0.0539617031034472 393 1357585 SGTC_1179 1021-1431 9.29 µM 1.60753414201367 0.03922811084023 no 181 0.0539686230206375 458 2840958 SGTC_3041 9091929 49.47 µM 1.60437426001789 0.0395176906979573 no 182 0.0543157906130648 383 25236887 SGTC_2433 5607874 27.82 µM 1.60377909364025 0.0395724274137953 no 183 0.0543813772185342 376 2252428 SGTC_275 trichlorophene 5.69 µM 1.60173446888964 0.0397609389751882 no 184 0.0546071697659045 574 62616 SGTC_1736 st036774 51 µM 1.5984929976847 0.0400612937763677 no 185 0.0549666512788602 382 1272247 SGTC_690 glyoxal 20.3 µM 1.59821471286746 0.0400871653546959 no 186 0.0549976002284664 429 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_872 0588-0139 234 µM 1.59766816528289 0.0401380162929268 no 187 0.0550584236197529 402 2047100 SGTC_259 usnic acid 108.925 µM 1.59690409259764 0.0402091936543017 no 188 0.0551435436974241 380 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2568 diosmetin 100 µM 1.59491312067782 0.0403951448349018 no 189 0.0553658325741136 397 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2324 6149169 200 µM 1.59299286347268 0.0405751523887228 no 190 0.0555808960131937 332 2888231 SGTC_1780 st038448 24.544 µM 1.5867187653974 0.0411678386629733 no 191 0.0562881771523368 366 728868 YDL195W SEC31 SGTC_2346 9031566 143.75 µM 1.58116273013406 0.0416985351770427 no 192 0.056920417306084 346 4771086 SGTC_606 k015-0008 38.6 µM 1.57708542068004 0.0420915025624116 no 193 0.0573879356942676 407 1970475 SGTC_221 trifluoperazine 10.304 µM 1.57472998594861 0.0423198797170341 no 194 0.0576593916373088 580 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2063 5246145 200 µM 1.57392001281464 0.0423986439584373 no 195 0.0577529712909804 402 711240 SGTC_355 1311-2252 105 µM 1.57229780225108 0.0425567491778022 no 196 0.0579407512514839 405 5338538 SGTC_2473 5854593 8.94 µM 1.56777863980162 0.0429997147283078 no 197 0.0584664007629209 340 2872951 SGTC_2309 7664088 163.95 µM 1.56370932555259 0.0434017669762064 no 198 0.058942923354629 435 704922 SGTC_1347 1493-0251 600 nM 1.56079595924601 0.0436914704249549 no 199 0.0592859505788439 403 3986378 SGTC_1976 st070609 63.5 µM 1.55666424138504 0.0441049994396598 no 200 0.0597751113776392 399 682556 SGTC_1762 st045503 25.4615 µM 1.55645517095922 0.0441260081528709 no 201 0.059799947361678 403 4645554 SGTC_1293 1000-1278 195 µM 1.55457694756732 0.0443151058885408 no 202 0.0600234287584938 405 678847 SGTC_2208 7283366 200 µM 1.55081205548942 0.0446961181092705 no 203 0.0604733653512127 387 898663 SGTC_1087 pterostilbene 9.05 µM 1.55053951603912 0.0447238015632761 no 204 0.0605060382891816 423 5281727 Similar to reservatol, lowers cholesterol. SGTC_995 3931-2021 34.6 µM 1.54790452023853 0.0449921664676719 no 205 0.0608226430891652 385 730143 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.54377060722039 0.0454158010673839 no 206 0.0613219571453885 414 688801 SGTC_410 α-linolenic acid 100 µM 1.53815909533592 0.0459959833889903 no 207 0.0620048598484611 426 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_234 nsc-17383 10.7 µM 1.52886337907417 0.0469701688993787 no 208 0.0631491581968665 462 408974 SGTC_2584 androsterone 48.74 µM 1.5253460014729 0.0473430752703034 no 209 0.0635864097986641 575 2754130 A steroid. SGTC_2077 5212015 200 µM 1.52375604298317 0.0475124167592037 no 210 0.0637848319591049 417 780900 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.51716466333418 0.0482196257705626 no 211 0.0646125577749303 515 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2670 beta-carotene 100 µM 1.51614884806821 0.0483293608200207 no 212 0.0647408594660052 302 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2327 6189656 200 µM 1.50831611937798 0.0491822265018047 no 213 0.0657368198024655 377 5349088 SGTC_1246 0422-0085 105 µM 1.49978802497747 0.0501244299371603 no 214 0.0668346601291255 463 264295 SGTC_1233 0325-0408 14.2 µM 1.49634914209835 0.0505084135581921 no 215 0.0672813476503813 425 12874 SGTC_797 k781-0471 270 µM 1.48992157694279 0.0512323923187163 no 216 0.0681224287253078 430 23738129 SGTC_869 0564-0080 44.1 µM 1.4892213919629 0.0513117549350781 no 217 0.0682145397320914 454 6843321 SGTC_2819 7996655 46.38 µM 1.48914742773763 0.0513201441339947 no 218 0.0682242755134442 375 6456960 SGTC_279 1273-0055 2.93 µM 1.48792088917425 0.0514594201924318 no 219 0.0683858790252899 465 2847562 SGTC_971 1315-0384 26.7 µM 1.48375814595618 0.0519343510183497 no 220 0.0689365471791692 438 6769120 SGTC_487 nimodipine 119 µM 1.4826511757192 0.0520612306532846 no 221 0.0690835564337676 297 4497 L-type voltage-gated calcium channels inhibitor SGTC_1956 st077085 54 µM 1.48102157638464 0.0522484613690507 no 222 0.0693004119987959 482 24208685 SGTC_2121 5257820 149.641 µM 1.47718338763783 0.0526915581618167 no 223 0.0698132428025353 456 791256 SGTC_1323 1348-1351 11.2 µM 1.47678967972831 0.0527371775849409 no 224 0.069866011921529 398 6989654 SGTC_1182 1222-0449 220 µM 1.47327828314741 0.0531454348847567 no 225 0.0703380070059832 415 658318 SGTC_641 4092-0595 30 µM 1.46918149445775 0.053624916363671 no 226 0.0708917841217486 463 786260 SGTC_390 dec-rvkr-cmk 16.7 µM 1.46856553159635 0.0536973030786199 no 227 0.0709753348071293 449 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_589 1227-0070 34.1 µM 1.46428164145934 0.0542028802419459 no 228 0.0715585055804886 429 2841384 SGTC_1398 3558-0053 112 µM 1.4627349669349 0.0543863388386738 no 229 0.0717699570977456 360 4532369 SGTC_1652 st011932 78 µM 1.46211929990542 0.0544595026410065 no 230 0.0718542604141988 424 1551076 SGTC_3177 9107506 49.47 µM 1.46025698060437 0.0546812883834951 no 231 0.0721097302047824 368 8897194 SGTC_54 0159-0055 9 µM 1.45885749909101 0.0548484237194719 no 232 0.072302166466368 449 3319099 SGTC_1893 st059353 36.1 µM 1.45749857741099 0.0550111012717853 no 233 0.0724894018834065 464 3112488 SGTC_766 1391-0721 126 µM 1.45541786821095 0.0552609230586475 no 234 0.0727768063364618 437 1020919 YIL115C NUP159 SGTC_772 k072-0172 35.3 µM 1.44695048458603 0.0562868197298559 no 235 0.0739553960616419 405 5861980 SGTC_2795 7780010 54.55 µM 1.44295802158686 0.0567757214852998 no 236 0.0745161484345335 425 953673 SGTC_1343 1487-0095 224 µM 1.43586045521875 0.0576531143228299 no 237 0.0755210264928226 424 4560101 YGL055W OLE1 SGTC_268 camptothecin 39.6153 µM 1.4356873503921 0.0576746457918661 no 238 0.0755456631500136 575 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2164 5685496 200 µM 1.43251873391341 0.0580698892317611 no 239 0.0759977102919102 468 759046 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.4286403981921 0.0585565542762149 no 240 0.0765538083143644 469 5282309 SGTC_2831 7999036 19.48 µM 1.42221488946231 0.0593698870031539 no 241 0.0774819388110598 504 2988270 SGTC_1242 0402-0103 60.1 µM 1.42086896295835 0.0595413693326953 no 242 0.0776774287129326 439 432868 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.41989478459565 0.0596657298214658 no 243 0.077819157259496 278 4000243 SGTC_1382 3002-2117 298 µM 1.41626522308533 0.0601308605545546 no 244 0.0783489329528995 481 1497314 SGTC_2490 carminic acid 95.39 µM 1.41526613960451 0.0602593907707775 no 245 0.0784952394352808 383 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1694 st024011 44.9 µM 1.41242764812116 0.0606257309355437 no 246 0.0789120401914722 503 2787533 SGTC_1658 st012944 20 µM 1.41090312167452 0.0608232065712574 no 247 0.0791365907973017 497 24207260 SGTC_655 k060-0012 42 µM 1.40942007278498 0.0610157918136071 no 248 0.0793554960500795 476 5994525 SGTC_1700 st030840 7.9285 µM 1.40047219408709 0.0621878734773836 no 249 0.0806859821763263 505 5499307 SGTC_1896 st058441 89 µM 1.39816038156855 0.062493534614099 no 250 0.0810324554832482 444 688759 SGTC_1600 coumarin 106 71.1 µM 1.396982570911 0.0626497110606156 no 251 0.0812094061766573 498 100336 A hepatotoxic, DNA x-linker. SGTC_2288 7946289 167.31 µM 1.395461367528 0.0628518709968222 no 252 0.0814383783917291 543 1246052 SGTC_2353 9059630 146.67 µM 1.39255689201448 0.0632392718138486 no 253 0.0818769131953027 443 4779114 SGTC_899 1083-0020 478 µM 1.39190272275582 0.0633267813287898 no 254 0.0819759286245044 496 767123 SGTC_2491 paeonol 100 µM 1.38726276916859 0.0639501853138628 no 255 0.0826808257284944 417 11092 Increases levels of cortical cytochrome oxidase. SGTC_322 k048-0136 19.3 µM 1.38584339282714 0.0641418367316523 no 256 0.0828973645139457 454 6823282 SGTC_1366 1683-0113 21.9 µM 1.38414857720957 0.0643712638838985 no 257 0.0831564825954982 461 708623 SGTC_1005 4092-0690 4.4 µM 1.38136098604811 0.0647500063651549 no 258 0.0835839976435693 478 1529343 SGTC_2282 7944268 200 µM 1.37832452136263 0.0651645292636046 no 259 0.084051557785762 532 2970414 SGTC_102 gallobenzophenone 83.616 µM 1.37699304348446 0.0653469441130765 no 260 0.0842571993067724 517 70837 SGTC_1138 3761-0006 1.03 µM 1.37696801682632 0.0653503765987054 no 261 0.0842610681879316 448 12061087 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.3769478415976 0.0653531437972021 no 262 0.0842641871817258 530 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_122 0236-0016 402.397 µM 1.37254751538316 0.0659588593996889 no 263 0.0849465288769902 567 6808838 SGTC_1134 3477-0009 42.5 µM 1.37212124798771 0.0660177665003843 no 264 0.085012847946745 548 3973534 SGTC_442 cape 100 µM 1.37174372701323 0.066069971223675 no 265 0.0850716154023506 456 5281787 SGTC_1618 st003135 44.5 µM 1.36975020080994 0.0663461724661651 no 266 0.0853824460752899 485 1270615 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.36952981778738 0.0663767611370212 no 267 0.0854168603566905 413 77254 SGTC_2981 9013952 38.96 µM 1.3674106712475 0.0666714515439022 no 268 0.0857483096829936 479 2996344 SGTC_2435 5706476 10.6 µM 1.36594568803215 0.0668757646358878 no 269 0.0859780055198654 530 5725375 SGTC_2249 haloperidol 116.36 µM 1.35420348892622 0.0685309260206328 no 270 0.0878357331190421 644 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_130 0136-0219 337.655 µM 1.35371361135877 0.0686006589277635 no 271 0.0879138819497748 512 234244 SGTC_3164 9100705 49.47 µM 1.34838963986173 0.0693620471598217 no 272 0.088766547189391 434 17174235 SGTC_3252 9135871 49.47 µM 1.34724992563303 0.0695258818890011 no 273 0.0889498767225278 504 17682838 SGTC_1884 5633444 25 µM 1.34285207778918 0.0701608701766514 no 274 0.0896599382282951 547 5724239 SGTC_1040 k898-0338 155 µM 1.34157759418736 0.0703457191317372 no 275 0.0898664975297813 558 20969351 SGTC_1505 k297-0037 20.6 µM 1.33904578781362 0.070714038649279 no 276 0.0902778836643737 533 4089396 SGTC_2794 7785382 27.27 µM 1.33896687384858 0.0707255425829072 no 277 0.0902907286138723 615 2205081 SGTC_1469 k284-2957 126 µM 1.33782097949065 0.0708927510659087 no 278 0.0904774006142921 486 23884841 SGTC_2087 5276107 200 µM 1.33724302729271 0.0709772007645176 no 279 0.0905716605943999 502 144405 SGTC_412 gemfibrozil 100 µM 1.33433652188535 0.0714030677498462 no 280 0.0910467967134954 446 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1830 st055982 50.3 µM 1.33070373047705 0.0719381058138078 no 281 0.0916432575385463 528 455313 An antimicrobial agent. SGTC_1449 4112-4002 201 µM 1.32673919084784 0.0725255061210188 no 282 0.0922974860045084 509 2059539 SGTC_2953 9074162 66.49 µM 1.32645288539804 0.072568067983036 no 283 0.0923448656251703 496 16451992 SGTC_2321 7390090 138.78 µM 1.3255658867118 0.0727000497117846 no 284 0.0924917659870886 473 649046 SGTC_2127 5253358 187.912 µM 1.32409747204835 0.0729189476582525 no 285 0.0927353375233704 474 20612 SGTC_119 0121-0043 24.815 µM 1.32385491392622 0.0729551545263002 no 286 0.0927756171721921 701 1092378 SGTC_2385 9074692 200 µM 1.32091598511365 0.0733949452089833 no 287 0.0932646895753199 539 17046906 SGTC_918 glabranin 770.725 nM 1.31550476195883 0.0742099978080403 no 288 0.0941701589996174 556 124049 Also referred to as licorice root. SGTC_1919 st067113 52.3 µM 1.31153240190417 0.0748127119055274 no 289 0.0948389770699259 561 1268243 SGTC_192 3455-0609 60.9 µM 1.31083429861455 0.0749190177563111 no 290 0.0949568759918622 529 3769639 SGTC_534 k292-0788 63.4 µM 1.31029322598262 0.0750014905088964 no 291 0.0950483290955425 592 4146317 SGTC_435 c-PAF 6.7 µM 1.30992536277481 0.0750576014230708 no 292 0.0951105430573167 559 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2229 7354935 190 µM 1.30920569081038 0.0751674670049469 no 293 0.095232342533054 457 318112 SGTC_306 1672-3436 11.6 µM 1.30754239688679 0.0754218556593691 no 294 0.0955142828583473 558 6797378 SGTC_763 3453-1109 128 µM 1.3021876282988 0.0762452856556859 no 295 0.0964261266766125 549 1560353 SGTC_1972 st070201 17.4 µM 1.2979977106698 0.0768943479155827 no 296 0.0971440608259572 559 2829099 SGTC_668 1682-0499 62.6 µM 1.29698964796965 0.0770511324742018 no 297 0.0973173743480973 611 682214 SGTC_2636 apigenin dimethyl ether 100 µM 1.29166241945523 0.0778837162640961 no 298 0.0982370386625928 588 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1141 3253-0389 52.6 µM 1.29103696453389 0.0779819137292471 no 299 0.0983454300596903 536 5402031 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.28967311727581 0.0781963657453539 no 300 0.0985820885904701 606 4174840 SGTC_2340 7987427 183.45 µM 1.2890486979661 0.0782946988960655 no 301 0.09869057857019 547 2239331 SGTC_774 k060-0086 136 µM 1.28788019621481 0.0784789656908142 no 302 0.0988938350931845 625 5911235 SGTC_422 cantharidin 155 µM 1.2812038120251 0.079538108405343 no 303 0.100061043762862 573 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2312 7706453 155.7 µM 1.28061468048371 0.0796320851793506 no 304 0.100164520488694 548 976098 SGTC_527 4476-4215 268 µM 1.27710489420989 0.0801936992475556 no 305 0.10078260861042 574 4418754 SGTC_2746 daunorubicin 9.88 µM 1.27572860220488 0.080414740200513 no 306 0.101025737051504 391 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1322 1348-1070 12 µM 1.2726925170797 0.080903981508876 no 307 0.101563586996105 521 6758089 SGTC_911 3456-4043 236 µM 1.26640392307978 0.0819244813342184 no 308 0.102684253554342 600 914281 SGTC_1306 1185-0270 9.02 µM 1.26587800384525 0.0820102639695464 no 309 0.102778381281408 632 1548076 SGTC_2581 avocatin a 64 µM 1.26548861999396 0.0820738199222972 no 310 0.102848112629138 614 6710728 A skin care supplement. SGTC_2151 5563267 85.4165 µM 1.26390579196186 0.0823325540737047 no 311 0.103131921334282 592 5310824 SGTC_42 0133-0086 60.653 µM 1.26319078068919 0.0824496333103669 no 312 0.10326031263687 525 162923 Model of phenazepam hydroxylation. SGTC_2918 7977171 22.06 µM 1.25989004795033 0.0829917358526333 no 313 0.103854514674192 537 2236483 SGTC_1010 4112-3296 15.2 µM 1.25901409967578 0.0831360481486083 no 314 0.104012619578545 621 704384 SGTC_283 0987-0079 11.7 µM 1.25884932006301 0.0831632166308576 no 315 0.104042381085431 612 411556 SGTC_2207 7258803 200 µM 1.25859388990697 0.0832053445603557 no 316 0.104088527554093 510 3666799 SGTC_292 k038-0015 474 µM 1.25835967196825 0.0832439880733039 no 317 0.10413085482616 536 46368540 SGTC_700 3453-2283 142 µM 1.2560068411144 0.0836329294821111 no 318 0.104556744883354 640 565664 SGTC_413 propylparaben 100 µM 1.25557263398801 0.0837048563255745 no 319 0.104635479208244 563 7175 A pharmaceutical preservative. SGTC_2545 solidagenone 89.61 µM 1.24579853160858 0.0853362672327018 no 320 0.106419184406001 363 6708572 An anti ulcer agent SGTC_269 exalamide 29 µM 1.24239374540652 0.0859101240348127 no 321 0.107045661090188 566 3316 A derivative of salicylamide. SGTC_3232 9132874 49.47 µM 1.23651673830605 0.0869074462267019 no 322 0.108133273915544 564 3784940 SGTC_2285 7945142 200 µM 1.23123275132069 0.0878114953004766 no 323 0.109117912676983 566 2970608 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.23093694200712 0.0878623125405513 no 324 0.109173224769437 655 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1229 0139-0193 12.2 µM 1.22975578485389 0.0880654428148154 no 325 0.109394285018584 644 3090752 SGTC_1085 doxorubicin 7.67 µM 1.22754349080581 0.088446845247231 no 326 0.109809193052801 643 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_513 4245-1575 41.7 µM 1.22695205617436 0.0885490175526119 no 327 0.109920305651464 734 719745 SGTC_1405 3909-7894 12 µM 1.22467913796057 0.0889424900479049 no 328 0.110348068725758 599 7104060 SGTC_687 k029-0044 34.9 µM 1.22203608887396 0.0894016721972128 no 329 0.11084698992849 633 5829338 SGTC_2716 st080858 38.6235 µM 1.22173350537722 0.0894543529151295 no 330 0.110904210730378 602 5296050 SGTC_2839 9003951 25.97 µM 1.22158517303604 0.0894801864642039 no 331 0.110932269213125 567 2990634 SGTC_1006 4099-6547 255 µM 1.22016023678407 0.0897286359829651 no 332 0.111202068630349 608 3146833 SGTC_2968 9090663 33.37 µM 1.21932104324676 0.0898751961276551 no 333 0.111361182359259 595 25236811 SGTC_551 k048-0028 34.9 µM 1.21776037068668 0.0901482312730778 no 334 0.111657523983368 652 6836383 SGTC_175 3793-3120 23.7 µM 1.21538707876726 0.0905646120899837 no 335 0.112109246925275 555 5322297 SGTC_1222 0366-0074 1.18 µM 1.21358247019035 0.0908821748549435 no 336 0.112453602196586 639 286520 SGTC_2641 levomentholum 100 µM 1.21346238235919 0.0909033363770065 no 337 0.112476544133199 560 16666 SGTC_3095 9117207 49.47 µM 1.21257176400466 0.0910603926095572 no 338 0.11264679487026 560 17015229 SGTC_2248 tofa 1.1 µM 1.21133285001371 0.0912792036789152 no 339 0.11288393180563 578 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1708 st033234 31.827 µM 1.20978423029318 0.0915532613741113 no 340 0.113180849457532 647 674664 SGTC_738 1315-0003 72.4 µM 1.20932888384616 0.091633959473207 no 341 0.113268259177563 648 6251474 SGTC_2802 7925815 54.55 µM 1.20789697436116 0.0918880709653869 no 342 0.11354344677475 623 1262923 SGTC_2994 9053520 71.4286 µM 1.20508003689348 0.0923894968384898 no 343 0.114086202810709 613 4647384 SGTC_1685 st024049 53.0905 µM 1.20387986461262 0.0926037462290483 no 344 0.114318007673906 583 1941139 SGTC_1261 0712-0010 12.7 µM 1.20133812810833 0.0930586986228642 no 345 0.114810032993317 656 2840123 SGTC_1765 st044815 90.4 µM 1.20025344123596 0.093253351851205 no 346 0.115020462951523 612 645695 SGTC_158 k038-0087 26.446 µM 1.1990142441059 0.093476100810994 no 347 0.11526120349965 737 X158 SGTC_833 3852-0053 558 µM 1.19877441145609 0.0935192567148808 no 348 0.115307837460576 697 3123681 SGTC_826 1683-5028 118 µM 1.19584265345135 0.0940479922007789 no 349 0.115878983698217 608 722377 SGTC_2096 5468907 200 µM 1.19582504794345 0.0940511739604752 no 350 0.115882419546917 611 759785 SGTC_164 4100-3994 89.624 µM 1.19570777067646 0.0940723709498339 no 351 0.115905308942969 696 4615967 SGTC_80 0159-0065 512.242 µM 1.1899467383419 0.0951179785374705 no 352 0.117033663362438 505 1548079 SGTC_2789 5281112 71.43 µM 1.18361440925699 0.0962771213982889 no 353 0.11828286692266 631 765948 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.18326373260425 0.0963416153936989 no 354 0.118352320740013 610 689007 SGTC_2784 7567673 72.73 µM 1.1806769124081 0.0968183464671638 no 355 0.118865548299616 675 3471247 SGTC_1796 st049173 110.4 µM 1.17753895782673 0.0973989697161616 no 356 0.119490228803369 588 94134 SGTC_1916 st067606 49.2 µM 1.17578196147407 0.0977251843735343 no 357 0.119841008229341 685 19590279 SGTC_3234 9132280 49.47 µM 1.17486591189736 0.0978955810745203 no 358 0.120024182644696 647 17612295 SGTC_1730 st033808 45.1 µM 1.17367759435485 0.0981169473550554 no 359 0.120262094005304 724 1045166 SGTC_2466 5983409 37.09 µM 1.17329051645487 0.0981891334655693 no 360 0.120339662009081 617 2879657 SGTC_449 xestospongin c 11.1929 µM 1.17128408979158 0.0985639352874953 no 361 0.120742302228941 671 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3342 9147791 14.508 µM 1.16830029865137 0.0991232446947787 no 362 0.121342827473744 649 1838168 SGTC_793 0488-0545 106 µM 1.16702926255764 0.0993622031606837 no 363 0.121599276172566 658 292548 SGTC_1697 st025554 27.742 µM 1.16695554730344 0.0993760747509596 no 364 0.121614160898543 603 1269519 SGTC_2755 lomerizine 42.69 µM 1.16682043335389 0.0994015039012974 no 365 0.121641446691693 666 3949 A calcium channel blocker. SGTC_1397 3532-0190 20.1 µM 1.16652723841308 0.0994567010783757 no 366 0.12170067118906 556 5322280 SGTC_1491 4138-0063 26.5 µM 1.16264708252287 0.100189294341895 no 367 0.122486359900707 609 23883227 SGTC_2481 5478948 45.16 µM 1.16220923635037 0.100272208630071 no 368 0.122575241887703 628 77792 SGTC_2130 NSC 7 2.4545 µM 1.1606601616019 0.100565956679665 no 369 0.122890064491264 690 21448 SGTC_1414 3917-0015 5.4 µM 1.15976670693501 0.100735665958182 no 370 0.123071901270724 622 6618702 SGTC_3308 9128332 17.569 µM 1.15974831411852 0.100739161816313 no 371 0.123075646575162 747 17332805 YDL196W YDL196W SGTC_2352 9027995 87.8 µM 1.15856120973949 0.100964977754541 no 372 0.123317544038661 599 2997347 SGTC_1608 st001473 40.5 µM 1.1581150973435 0.101049934435806 no 373 0.123408534871179 615 7292267 SGTC_1749 st037932 54.2 µM 1.15749773680378 0.101167589174866 no 374 0.123534531710122 615 594497 SGTC_933 2914-0560 114 µM 1.15423545407358 0.101790963122154 no 375 0.124201825408151 719 463887 SGTC_572 0960-0087 17.7 µM 1.15165678518985 0.102285683663774 no 376 0.124731068463835 702 6796365 SGTC_2218 6965428 192.983 µM 1.15133867295884 0.102346834822049 no 377 0.124796466498458 655 675684 SGTC_1292 0kpi-0043 232 µM 1.15048710452603 0.102510663850199 no 378 0.124971651243336 631 3333905 SGTC_538 2922-0838 53.3 µM 1.14866259820025 0.102862313255723 no 379 0.125347566999281 732 777039 SGTC_1554 st069299 38.7 µM 1.14558787202302 0.103456907656184 no 380 0.125982858892057 658 24207999 SGTC_3182 9108849 49.47 µM 1.14531463971116 0.103509866109916 no 381 0.1260394218643 679 17133045 SGTC_2621 lithochol-11-enic acid 100 µM 1.14318591001706 0.10392313478006 no 382 0.126480705517178 707 6708711 SGTC_2292 7671323 168.05 µM 1.14231926567611 0.104091726233042 no 383 0.126660668002163 662 937504 SGTC_3297 9117502 71.43 µM 1.14212494694907 0.104129554956715 no 384 0.126701043597678 658 7453720 SGTC_2657 nystatin 74.44 µM 1.14120945238743 0.104307911659335 no 385 0.12689138587361 702 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1524 corynanthine 62.1 µM 1.13438753868618 0.105643932664562 no 386 0.128316011931333 644 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2394 5221648 200 µM 1.13236851765607 0.106041705548033 no 387 0.128739767445808 762 788586 SGTC_1379 2144-0755 36.5 µM 1.1302854689707 0.106453225694586 no 388 0.12917797775285 729 5392327 SGTC_1793 st048256 72.231 µM 1.13008160797559 0.106493561652335 no 389 0.129220919411422 676 672022 SGTC_2539 epi(13)torulosol 80 µM 1.12834782011966 0.106837055139192 no 390 0.12958652764942 649 6708597 SGTC_541 4513-1321 94 µM 1.12727046976178 0.107050899256525 no 391 0.129814071889091 661 747515 SGTC_273 hydroxyurea 18.1 mM 1.1214313125843 0.108215290153512 no 392 0.131052156908042 755 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3137 9097352 49.47 µM 1.12040845370309 0.108420194007567 no 393 0.131269872066571 725 44120435 SGTC_2331 7980721 200 µM 1.11744282036321 0.109015861157871 no 394 0.131902517521553 706 2981221 SGTC_1654 st012436 41.8 µM 1.11399789563673 0.109710746026484 no 395 0.132640044716737 642 4323132 SGTC_1151 3909-8316 15.3 µM 1.10422788931966 0.111698761369122 no 396 0.134747147236881 704 800431 SGTC_466 geldanamycin 89.2 µM 1.10070493092344 0.112421901770189 no 397 0.135512549748596 574 5288382 HSP90 inhibitor. SGTC_1059 3448-6867 171 µM 1.10037907428165 0.112488957373374 no 398 0.135583496006077 712 3934407 SGTC_431 k089-0097 107 µM 1.10037203684783 0.112490405869411 no 399 0.13558502849303 754 5499420 SGTC_809 3998-0021 90 µM 1.09299962639459 0.114015175062239 no 400 0.137196981891985 686 715485 SGTC_391 gliotoxin 8.33 µM 1.09168535356678 0.114288533410385 no 401 0.137485712537769 754 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1727 st034309 9.9045 µM 1.09038029410702 0.114560436927295 no 402 0.137772829323155 793 870305 SGTC_2663 amphotericin b 100 µM 1.08637804965842 0.115397157368017 no 403 0.138655884400557 669 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.08353221111141 0.115994752423057 no 404 0.139286130738988 695 688662 SGTC_2586 curcumin 80 µM 1.08324636036281 0.116054899161683 no 405 0.139349543499539 815 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_266 formosanin C 406 nM 1.08045564956132 0.116643264542281 no 406 0.139969663081486 734 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2736 butenafine 14.65 µM 1.07774613611315 0.117216531801576 no 407 0.140573531610456 764 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3012 9080433 71.4286 µM 1.07747802182906 0.117273366601969 no 408 0.140633382176741 753 17688859 SGTC_1954 st077032 68.9 µM 1.07676484251372 0.117424641184054 no 409 0.140792667815922 635 698907 SGTC_206 4546-0025 72.014 µM 1.0765784453828 0.117464201199098 no 410 0.140834319011045 799 6620745 YIL048W NEO1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.07582144273616 0.11762496071981 no 411 0.141003560235431 681 17037758 SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.07459032989159 0.11788673628407 no 412 0.141279091586382 788 1273210 SGTC_2139 5578692 56.4705 µM 1.07411520424563 0.117987873963084 no 413 0.141385525452948 676 650991 YMR113W FOL3 SGTC_552 k242-0005 476 µM 1.07172154704935 0.118498333627186 no 414 0.141922559913866 723 4088318 SGTC_1764 st044502 93.5 µM 1.07017254435445 0.118829497089429 no 415 0.14227082511937 732 8407 SGTC_179 1273-0063 6.77 µM 1.06818747459238 0.119254842855562 no 416 0.142717976806158 676 3108139 SGTC_3246 9135460 32.98 µM 1.06247079354169 0.12048576972648 no 417 0.144011005084224 661 41446951 SGTC_3293 9120939 62.045 µM 1.06084643428395 0.120837156596283 no 418 0.144379847940136 723 934087 SGTC_1096 rimcazole 32.2 µM 1.0595648388318 0.121114904192861 no 419 0.144671308444951 710 18528119 A dopamine reuptake inhibitor. SGTC_3200 9114385 49.47 µM 1.05660381651113 0.121758334031426 no 420 0.145346218988846 692 17018030 YLR208W SEC13 SGTC_731 3966-0296 387 µM 1.05464380711716 0.122185562718471 no 421 0.145794130285434 750 660956 SGTC_376 3970-0862 59.1 µM 1.05435482431499 0.122248642020342 no 422 0.145860248498174 766 3135186 SGTC_3287 9117173 37.0625 µM 1.0525385054514 0.122645632353296 no 423 0.146276276959024 706 2789709 SGTC_988 1497-1057 103 µM 1.04975444452111 0.123255894741186 no 424 0.14691551247229 780 3533044 SGTC_1879 gemcitabine 100 µM 1.04837174021145 0.123559771173526 no 425 0.147233684210465 764 60750 A nucleoside analog which inhibits DNA replication. SGTC_737 1950-0117 57.9 µM 1.04763134083319 0.123722704005505 no 426 0.147404245993603 752 5393513 SGTC_959 1222-0044 107 µM 1.04518595787427 0.124261905419208 no 427 0.147968516060439 761 6083612 SGTC_957 1187-1561 14.1 µM 1.04405597878376 0.124511617693021 no 428 0.148229745577201 759 1538454 SGTC_1259 0671-0132 43 µM 1.04260016296812 0.124833852983151 no 429 0.148566756878024 732 X1259 SGTC_1751 st044839 27.194 µM 1.04211584119599 0.124941183493207 no 430 0.148678987498952 754 5291326 SGTC_497 capsazepine 133 µM 1.04137847880396 0.125104714075815 no 431 0.148849963359434 742 2733484 A calcium channel blocker. SGTC_1714 st033236 13.627 µM 1.04096607213374 0.125196241860387 no 432 0.148945647401975 766 2916566 SGTC_1304 1165-0502 251 µM 1.03866446959161 0.125707908381224 no 433 0.149480405506037 792 767425 SGTC_3135 9127742 49.47 µM 1.03191394841491 0.127217016008166 no 434 0.151056215533616 704 3643468 SGTC_2447 5741742 33.78 µM 1.02891108858728 0.12789235230837 no 435 0.151760728615571 779 1776504 SGTC_2772 vinpocetine 57.06 µM 1.02663007405416 0.128407009305256 no 436 0.152297343614149 759 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3303 9125618 40.5795 µM 1.02543760303618 0.128676633719917 no 437 0.152578376493229 839 22695467 SGTC_397 arbidol 50 µM 1.02410831778634 0.12897765533665 no 438 0.152892058053143 823 131410 A RNA synthesis inhibitor. SGTC_1676 st018489 23.4 µM 1.02380472597681 0.129046473285777 no 439 0.152963758863885 778 3696235 SGTC_1993 st073995 70.8 µM 1.02269760214232 0.129297650938326 no 440 0.153225422746196 793 3098394 SGTC_2201 6605497 169.863 µM 1.02183211380944 0.129494243608047 no 441 0.153430183581825 788 670741 SGTC_2576 guaiol 23.12 µM 1.01487583310333 0.131081860552196 no 442 0.155082509733628 836 227829 SGTC_2275 7947463 200 µM 1.00857046733124 0.132532494219879 no 443 0.156590338360203 758 1225414 SGTC_581 0958-0271 211 µM 1.00635262353496 0.133045358462117 no 444 0.157122987443508 838 4591145 SGTC_1992 st073643 23.3 µM 1.00634980417932 0.1330460112909 no 445 0.157123665312285 779 3161292 SGTC_1783 st039459 87.517 µM 1.00503975067798 0.133349596000424 no 446 0.157438854713243 839 729761 SGTC_1216 1165-0504 9.65 µM 1.00457286634733 0.133457904343285 no 447 0.157551284077267 819 6304004 SGTC_636 0kpi-0074 126 µM 1.00179716285069 0.134103064175442 no 448 0.158220783892021 763 616434 SGTC_653 0203-0016 55.2 µM 1.00041199178655 0.134425821142927 no 449 0.15855558451609 823 295302 SGTC_3327 9140648 26.9345 µM 0.99990580878832 0.134543899159945 no 450 0.158678046520571 787 8029710 SGTC_2257 7960413 200 µM 0.999017526472804 0.134751282073783 no 451 0.158893100544268 853 2974689 YIL048W NEO1 SGTC_1814 st052110 31.539 µM 0.998375108051871 0.134901400958855 no 452 0.159048749647758 787 674163 SGTC_1978 st071761 42 µM 0.997659258578614 0.13506881414327 no 453 0.159222307715814 764 5147680 SGTC_519 k048-0011 62.8 µM 0.994187723543719 0.135882710221492 no 454 0.160065741848619 795 6836379 SGTC_2532 xanthone 78.9 µM 0.991079360784929 0.136614305274948 no 455 0.160823415087028 738 7020 An insecticide. SGTC_2211 7117706 200 µM 0.989655346545949 0.13695036421274 no 456 0.1611713038593 777 822771 SGTC_1031 k035-0009 16 µM 0.988716891455696 0.137172142646416 no 457 0.161400838022846 877 5180959 SGTC_2936 9038235 15.59 µM 0.988055644907694 0.137328557610138 no 458 0.161562698469174 784 4749415 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.987906351754492 0.137363889096821 no 459 0.161599257201946 824 688667 SGTC_208 k072-0098 12.366 µM 0.98701055275641 0.13757601785996 no 460 0.161818732661307 914 5948901 SGTC_2983 9022671 12.99 µM 0.986651287792939 0.137661156021425 no 461 0.161906809007621 787 6405161 SGTC_3203 9113543 49.47 µM 0.983493003100711 0.138411149844774 no 462 0.162682428634838 762 17018012 SGTC_1120 ficusin 1.78878 µM 0.983186659537631 0.13848404473467 no 463 0.16275778964857 832 6199 A DNA cross-linker. SGTC_199 4063-0024 41.6 µM 0.979897734732668 0.139268297246416 no 464 0.163568300631001 844 306215 SGTC_557 1315-0110 16.2 µM 0.979869843768543 0.139274960814917 no 465 0.163575185169614 828 6833801 SGTC_801 0866-0028 10.1 µM 0.979806848544642 0.13929001211449 no 466 0.163590735451822 843 6849771 SGTC_1967 st070177 51.4 µM 0.97617880935591 0.140158718588255 no 467 0.164487931204898 802 5729214 SGTC_963 1269-2853 151 µM 0.971536789457429 0.141275571739241 no 468 0.165640521117587 794 3668223 SGTC_301 4119-0100 24.5 µM 0.971536243734802 0.141275703391801 no 469 0.165640656924036 847 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_724 3910-0327 137 µM 0.96867674460957 0.141966683818741 no 470 0.1663532495458 840 2885483 SGTC_2192 5915882 198.485 µM 0.967356515459193 0.142286479880972 no 471 0.166682920142295 807 2876149 SGTC_3176 9106582 49.47 µM 0.964025537155609 0.143095499950818 no 472 0.167516561414986 714 17018027 SGTC_779 1360-0071 233 µM 0.960971853071204 0.143839896770649 no 473 0.168283160229374 906 7566 SGTC_1758 st042942 75.2445 µM 0.960851327989523 0.143869330672573 no 474 0.168313463141036 842 669317 SGTC_1315 1237-0019 3.69 µM 0.960762810084326 0.143890950564347 no 475 0.168335720912012 878 825140 SGTC_2923 7992654 58.14 µM 0.960022131654825 0.144071942086944 no 476 0.168522038220306 815 2985126 SGTC_103 0844-0104 51.839 µM 0.958003108867707 0.1445660880296 no 477 0.169030595449784 940 5375804 SGTC_2078 5212016 200 µM 0.957920675071603 0.144586287530012 no 478 0.169051380032021 812 1899708 SGTC_2193 5925765 200 µM 0.954200399998299 0.145499879705403 no 479 0.169991106113846 827 877370 SGTC_2920 7982904 15.77 µM 0.953614061815821 0.145644220814409 no 480 0.170139517594292 794 6456808 SGTC_1828 st055811 49 µM 0.953330852044573 0.145713974114427 no 481 0.170211232202507 818 5877589 SGTC_1127 asiatic acid 681.4 nM 0.950181835961309 0.146491075725078 no 482 0.171009933225882 799 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2933 9026794 32.47 µM 0.948529600969764 0.14689991839963 no 483 0.171429955400308 857 17586027 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.944997753878154 0.147776432194425 no 484 0.172330011370934 872 2724 A muscle relaxant with antifungal properties. SGTC_2551 apiole 73.87 µM 0.944117957056024 0.14799531890903 no 485 0.172554686994517 725 10659 A possible DNA adduct former. SGTC_1756 st041558 35.5 µM 0.942369647689341 0.148430928686751 no 486 0.173001710662257 947 3955792 SGTC_1509 1326-1131 80 µM 0.940147525560674 0.148985830312633 no 487 0.173570946890574 848 768313 SGTC_844 0330-0132 15.3 µM 0.939558111014417 0.149133249391275 no 488 0.173722135715963 918 2828079 SGTC_220 paclitaxel 373.376 µM 0.937672428498231 0.149605533609159 no 489 0.174206388595548 800 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2836 9010338 19.48 µM 0.936218612232406 0.149970334099228 no 490 0.174580321090914 810 2994051 SGTC_2607 solasodine 47.35 µM 0.932820059248087 0.150825432106659 no 491 0.175456441240474 866 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2434 5670830 169.91 µM 0.932346183931115 0.150944919546155 no 492 0.175578823579292 853 1549830 SGTC_1212 0520-0165 585 µM 0.932345584114972 0.150945070829428 no 493 0.175578978521195 843 5403258 SGTC_2380 9035439 200 µM 0.932177556098919 0.15098745416984 no 494 0.175622386200884 930 6462575 SGTC_19 0279-0214 38.434 µM 0.930383717003348 0.151440425235756 no 495 0.176086223102489 958 3566274 YBR002C RER2 SGTC_1932 st074806 40.9 µM 0.927855653658122 0.152080331405831 no 496 0.176741225272057 923 17251235 SGTC_2879 9041815 71.43 µM 0.92621110758673 0.152497563344851 no 497 0.177168140595255 800 4942971 SGTC_1722 st034304 3.6505 µM 0.925767560419548 0.15261022405781 no 498 0.177283394491769 862 4036148 YLR033W RSC58 SGTC_3262 9137218 49.47 µM 0.922925317829207 0.153333462302168 no 499 0.178023062843252 740 17650664 SGTC_1744 st037937 38.9 µM 0.918688801053373 0.154415696397742 no 500 0.179129184560893 865 1016152 SGTC_823 0417-1665 178 µM 0.917955913358952 0.154603426432559 no 501 0.179320973590535 901 3429856 SGTC_1836 st055642 81 µM 0.91702110948897 0.154843096334297 no 502 0.179565789275045 911 8571 SGTC_176 1486-1328 72.834 µM 0.914418635177413 0.155511624397332 no 503 0.180248456768564 919 22310231 SGTC_1374 2889-5571 141 µM 0.913630295297386 0.155714509709237 no 504 0.180455570986323 902 2853281 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.912780846443412 0.155933317170259 no 505 0.180678906902039 1052 688664 SGTC_600 1495-0418 41.6 µM 0.912597972475799 0.155980449730377 no 506 0.180727010534899 868 5377768 SGTC_1314 1222-0010 41.1 µM 0.912059449578458 0.156119299103023 no 507 0.180868711597069 900 3526027 SGTC_673 1082-0474 110 µM 0.911751536660864 0.156198726028055 no 508 0.180949763737763 982 3098046 SGTC_3214 9129694 49.47 µM 0.910885123111883 0.156422362447571 no 509 0.181177952512582 851 17158655 SGTC_2549 cedrol 20.94 µM 0.909892236384112 0.156678902947373 no 510 0.181439672261977 880 6708665 A sedative which affects the nervous system. SGTC_1906 st060206 94.7 µM 0.90657797233316 0.157537241225921 no 511 0.182315007337478 950 5133468 SGTC_1809 st050081 57.6 µM 0.905725659347593 0.157758474406163 no 512 0.182540538810248 894 5036894 SGTC_2696 st077691 74.316 µM 0.902627317424437 0.158564423277831 no 513 0.183361861614678 821 757133 SGTC_2707 st078556 66.6 µM 0.901197347898841 0.158937299803895 no 514 0.183741700408244 910 17250899 SGTC_1638 st008370 60.6 µM 0.900778447362547 0.159046640358051 no 515 0.183853064548818 880 24207134 SGTC_439 amiodarone 34.4 µM 0.900664452497177 0.159076403591129 no 516 0.183883377204612 902 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3090 9117696 49.47 µM 0.900391754222909 0.159147617938257 no 517 0.183955903703375 894 7923821 SGTC_2967 9089538 49.85 µM 0.899889135871706 0.159278929941602 no 518 0.184089626127717 933 728216 SGTC_2710 st078562 53.7235 µM 0.898149072192863 0.159734079682166 no 519 0.184553040096876 932 17250908 SGTC_938 3126-1755 342 µM 0.896595150419134 0.160141258740519 no 520 0.184967493389734 966 1777771 SGTC_2685 mycophenolic acid 18.85 µM 0.89657782445595 0.1601458025395 no 521 0.18497211773104 908 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2857 9024691 58.44 µM 0.896447045915659 0.160180102422469 no 522 0.185007025155923 884 16478292 SGTC_1147 3809-1045 12.3 µM 0.895561501862845 0.160412484438255 no 523 0.185243502365062 881 325925 SGTC_1232 0279-0259 161 µM 0.8954093005719 0.160452446852377 no 524 0.185284165355056 917 1560000 SGTC_2999 9069765 71.4286 µM 0.891618679280343 0.161449821510725 no 525 0.186298677301398 941 2097066 SGTC_2141 5621638 7.665 µM 0.891479448045281 0.161486532341506 no 526 0.186336006197185 930 2856238 SGTC_1320 1313-0481 95.3 µM 0.890781870900002 0.161670543100216 no 527 0.186523101409983 969 6813365 YLR208W SEC13 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.890163432519546 0.161833792441267 no 528 0.186689068290128 868 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_567 1080-0542 68.4 µM 0.88982030782669 0.161924413468607 no 529 0.186781190182611 869 5950415 SGTC_765 1319-0117 244 µM 0.889818526616487 0.161924883981779 no 530 0.186781668474155 904 3487746 YGL099W LSG1 SGTC_2708 st078559 56 µM 0.887515930935766 0.162533867801323 no 531 0.187400596518547 831 17250902 SGTC_1947 st076332 61.6 µM 0.886971904548185 0.162677967685139 no 532 0.187547013462417 911 24208416 SGTC_1475 4092-1048 11.7 µM 0.886913925938997 0.1626933297634 no 533 0.187562621745415 938 2881759 SGTC_2238 6671620 73.2395 µM 0.886025776961713 0.162928772664617 no 534 0.18780181852462 966 729941 SGTC_304 1310-0298 97 µM 0.88408571551787 0.163443841240079 no 535 0.188324971815061 926 1550234 SGTC_3142 9086498 49.47 µM 0.881940323412246 0.164014653266317 no 536 0.18890453984075 873 25236367 SGTC_1319 1306-0155 43.7 µM 0.880804156952802 0.164317469672469 no 537 0.18921191470585 951 3122360 SGTC_726 3448-4391 34.2 µM 0.880383183289163 0.164429761525203 no 538 0.189325881728809 973 1356692 SGTC_868 0527-0199 213 µM 0.880113069141279 0.164501838823956 no 539 0.189399029943706 929 2849450 SGTC_835 0312-0010 67.2 µM 0.879503555796631 0.164664556680521 no 540 0.189564152996929 901 1626196 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.879420428313999 0.164686756768354 no 541 0.189586679896549 926 140250 A respiratory chain inhibitor. SGTC_398 bronopol 33.3 µM 0.87829713066353 0.164986935616194 no 542 0.189891246272465 938 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3187 9109394 49.47 µM 0.877563127539526 0.165183274545289 no 543 0.190090423315081 930 17098090 SGTC_152 4469-0003 551.229 µM 0.875353023701777 0.165775369343103 no 544 0.190690925823824 948 697280 SGTC_608 k048-0125 159 µM 0.875352088782472 0.165775620101337 no 545 0.190691180094827 966 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_147 4466-0538 29.23 µM 0.874865265539412 0.165906226107358 no 546 0.19082361019663 1016 6742687 YHR072W ERG7 SGTC_2253 7938677 135.83 µM 0.874110266949837 0.166108910293522 no 547 0.191029103390942 946 2301972 SGTC_3111 9122088 49.47 µM 0.8740940467601 0.166113266461494 no 548 0.191033519640956 841 16876704 SGTC_1553 gossypol 38.6 µM 0.873348136505993 0.166313671248198 no 549 0.191236675299993 866 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1271 0832-2808 169 µM 0.873190318437435 0.166356092460828 no 550 0.191279675501396 981 3663794 SGTC_426 0988-0037 14.6 µM 0.872673232548862 0.16649513316181 no 551 0.191420605811172 971 5383008 SGTC_935 2996-0153 430 µM 0.872645042608293 0.166502715391225 no 552 0.191428290728955 944 23738523 SGTC_2513 baicalein 25.65 µM 0.872211118879874 0.166619455687882 no 553 0.191546607421504 935 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_465 cgp-37157 41 µM 0.872072569661601 0.166656741281048 no 554 0.191584394658403 846 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_575 k072-0246 11.9 µM 0.86871247316624 0.167562640233545 no 555 0.192502208656364 969 6796779 SGTC_1842 st055362 61.2 µM 0.868551263774765 0.167606182694965 no 556 0.192546310645794 997 676032 SGTC_1105 epirubicin 18.1 µM 0.866926860263657 0.168045338769835 no 557 0.192991042647349 915 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2032 5185112 25.99 µM 0.865591906653723 0.168406796137311 no 558 0.193356997733217 905 5718189 SGTC_1846 st056244 14.8 µM 0.864443555284565 0.168718128061529 no 559 0.193672137491104 963 5393182 SGTC_1829 berberine 14.4 µM 0.862987270718858 0.169113476010635 no 560 0.194072232859693 954 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1354 1498-1681 81 µM 0.862195372741394 0.169328707692564 no 561 0.194290007797284 991 5754243 SGTC_3071 9117417 49.47 µM 0.862043160041646 0.169370098052201 no 562 0.194331883908862 884 45595590 YGL055W OLE1 SGTC_492 tmb-8 126 µM 0.861271632959962 0.169579995017868 no 563 0.194544227674995 817 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_109 0132-0036 33.701 µM 0.858379194348363 0.17036837906764 no 564 0.19534155615583 842 67274 A color developer. SGTC_2591 skatole 100 µM 0.854451438935473 0.171442708708096 no 565 0.196427452553779 958 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2602 kawain 100 µM 0.849709735174761 0.172745427012547 no 566 0.197743242310799 1022 5369129 SGTC_1457 k015-0032 57.3 µM 0.84830129257812 0.173133589651228 no 567 0.198135098964646 954 4302660 SGTC_1968 st069590 43.6 µM 0.848145322467923 0.17317660869466 no 568 0.198178521756639 957 6384066 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.84805386088877 0.173201838422736 no 569 0.198203987750603 1060 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1877 wortmannin 25 µM 0.847497429891183 0.173355380661817 no 570 0.198358959503383 1002 312145 A covalent inhibitor of PI 3-kinase. SGTC_1410 3909-8106 77.9 µM 0.84615978918831 0.173724845267174 no 571 0.198731805244116 982 1039210 SGTC_2030 5175110 200 µM 0.845996224513659 0.173770057183999 no 572 0.198777425231731 973 2831986 SGTC_1612 st002233 45.4 µM 0.845483944035633 0.173911708202695 no 573 0.198920346742281 976 1035021 SGTC_2863 9028737 58.44 µM 0.84523817970155 0.173979690719117 no 574 0.198988934694032 983 6460917 SGTC_2993 9054257 71.4286 µM 0.84503455316342 0.17403603001544 no 575 0.199045773616627 1030 6470217 YGL055W OLE1 SGTC_3237 9133362 49.47 µM 0.842302410518672 0.174793079552837 no 576 0.199809351062944 964 43845137 SGTC_2555 cholic acid 100 µM 0.840969586011907 0.175163149395423 no 577 0.200182486526615 968 6708657 Influences liver metabolism. SGTC_1866 st057638 64 µM 0.840949659664404 0.175168685879729 no 578 0.20018806825109 971 688802 SGTC_1875 nocodazole 6 µM 0.840723127712395 0.175231635001998 no 579 0.200251530457187 988 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_862 0452-0056 10.2 µM 0.838429570397059 0.175869780728899 no 580 0.200894743813607 969 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2862 9027634 71.43 µM 0.836596906077207 0.176380746864409 no 581 0.201409592637849 904 5012562 SGTC_2450 5739737 12.93 µM 0.833637127814064 0.177207945332577 no 582 0.202242748533057 948 2262825 SGTC_1973 st070275 50.2 µM 0.833116697090425 0.177353648137115 no 583 0.202389458805717 983 17118334 SGTC_4 0960-0234 25.671 µM 0.832849188215958 0.177428570897656 no 584 0.202464894753004 967 6821112 SGTC_3235 9132602 49.47 µM 0.831911245394098 0.177691423796909 no 585 0.20272952195021 1022 4912240 SGTC_1067 clotrimazole 1.36 µM 0.831093293033866 0.177920850533653 no 586 0.202960464168491 1015 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2810 7959871 45.46 µM 0.829995691569364 0.178229009194314 no 587 0.203270609799813 1022 2974535 SGTC_507 nimesulide 162 µM 0.829141971340477 0.178468929058263 no 588 0.203512038157501 1001 4495 A COX2 inhibitor. SGTC_107 0358-0022 2.6945 µM 0.828850982869829 0.178550751630461 no 589 0.203594367496516 913 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_471 1-acyl-paf 4 µM 0.828098411547245 0.178762475476993 no 590 0.203807384516897 981 16759367 SGTC_1448 4255-0083 152 µM 0.827952590891095 0.178803518047177 no 591 0.203848674743802 1048 5399660 SGTC_1815 st051655 58.2 µM 0.826850970102814 0.179113771038767 no 592 0.204160768116931 983 5984156 SGTC_1892 st058411 7.36 µM 0.82672378382809 0.179149612710937 no 593 0.204196818789683 1028 3934738 SGTC_1142 3253-1408 9.78 µM 0.824697614228194 0.179721204848845 no 594 0.204771643260542 986 256655 SGTC_1489 4065-0444 182 µM 0.823697323651137 0.180003813600349 no 595 0.205055780265411 998 2877968 SGTC_2526 patulin 37.61 µM 0.822626710140163 0.180306599431961 no 596 0.20536015229546 1031 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3313 9133968 57.047 µM 0.819537477496639 0.18118207180693 no 597 0.206239914314916 1038 1494643 SGTC_1508 1080-0625 72.9 µM 0.818725376656712 0.181412658172442 no 598 0.206471557416026 965 767111 SGTC_3231 9132313 49.47 µM 0.816614956833562 0.182012745369661 no 599 0.207074252455227 1006 4905967 SGTC_813 k007-0158 173 µM 0.814118736391816 0.182724133225178 no 600 0.207788466625761 1076 6523916 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.813888546822846 0.182789821332192 no 601 0.207854401248342 910 88881 An O-methylated flavonoid and antioxidant. SGTC_2544 sphondin 68.51 µM 0.813825553318238 0.182807800058909 no 602 0.207872447020671 999 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_249 wiskostatin 11.211 µM 0.81382499603748 0.182807959115129 no 603 0.207872606669223 1042 2775510 A n-wasp and actin depolymerizer. SGTC_2220 6782180 200 µM 0.812991467579055 0.183045957226201 no 604 0.208111475081987 967 833803 SGTC_2778 tioconazole 65.09 nM 0.811955454824939 0.183342040181487 no 605 0.20840859612936 988 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_458 nppb 133 µM 0.811810335625712 0.183383537750065 no 606 0.20845023524549 1009 4549 A chloride channel blocker. SGTC_2397 5161689 200 µM 0.811310634433315 0.183526474624882 no 607 0.20859365225793 1019 2259942 SGTC_2650 prasterone 100 µM 0.809517181501375 0.184040053937053 no 608 0.209108862019944 1007 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1378 2093-0007 380 nM 0.808829225798688 0.184237296499295 no 609 0.209306691465511 996 3618014 SGTC_934 2950-0684 338 µM 0.808729727284615 0.184265834427539 no 610 0.209335312503915 1061 1121253 SGTC_3117 9124945 49.47 µM 0.80854572062997 0.184318618027651 no 611 0.209388248624016 928 17592065 SGTC_2493 resveratrol 26.09 µM 0.807806753633514 0.18453069063926 no 612 0.209600918333818 971 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1490 4089-0339 670 nM 0.804770618411965 0.185403608255266 no 613 0.210476029816219 1006 742542 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.804442489531069 0.185498101662577 no 614 0.210570735315839 977 61125 An anti-inflammatory. SGTC_329 k048-0121 21.3 µM 0.803666058713519 0.185721814510503 no 615 0.210794930574686 1008 6832902 SGTC_1513 0337-0559 19 µM 0.801109245368966 0.186459690974562 no 616 0.211534202171281 958 775073 SGTC_2320 7373003 200 µM 0.799890427318793 0.186812070590446 no 617 0.211887142254768 1065 5415828 SGTC_72 0744-0168 198.391 µM 0.799215800699067 0.187007292923649 no 618 0.212082645748644 988 677577 SGTC_1351 1496-0003 46.5 µM 0.797591512709423 0.18747784420466 no 619 0.212553788941185 1069 3891978 SGTC_1692 fluoroquinolonic acid 71 µM 0.797153210975348 0.187604944143924 no 620 0.212681028002039 1021 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_512 prima-1 270 µM 0.796763292239489 0.187718058585286 no 621 0.212794258844085 1063 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2226 7298446 200 µM 0.79654542153602 0.187781280668988 no 622 0.212857542947541 1031 3283010 SGTC_1771 st048882 4.1505 µM 0.795153012573077 0.188185642746499 no 623 0.213262250228207 1063 4580403 SGTC_1661 st013063 9.66 µM 0.794132078715512 0.188482467864756 no 624 0.213559272194654 1112 721395 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.793316043557602 0.188719928472431 no 625 0.213796855887808 1056 6710655 SGTC_2905 7799065 20.05 µM 0.793252838234145 0.188738328477161 no 626 0.213815264155488 1010 1296806 SGTC_2086 5274770 176.623 µM 0.792369916975503 0.188995475510877 no 627 0.214072507508646 1012 689278 SGTC_2689 tacrolimus 100 µM 0.792251422156829 0.189030003037619 no 628 0.214107045247409 1020 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_110 0850-0284 111.64 µM 0.792246189858893 0.189031527736521 no 629 0.214108570382422 920 3906265 SGTC_2886 9058944 51.95 µM 0.791513698519649 0.189245051487669 no 630 0.214322142818187 915 4949929 SGTC_2890 9046729 58.44 µM 0.791182128941806 0.189341753965719 no 631 0.214418859256443 978 903329 SGTC_65 0798-0905 34.986 µM 0.789596435979851 0.189804642760298 no 632 0.214881745166567 1095 3602145 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.785880972870668 0.19089196747314 no 633 0.215968611296448 1068 7104 SGTC_1605 st000082 49.1 µM 0.783550948382987 0.191575791218409 no 634 0.216651823747345 1065 1114022 SGTC_2524 avocatin b 10.57 µM 0.781169560719837 0.192276237597814 no 635 0.217351387016889 1020 6710748 SGTC_717 1532-0246 73.2 µM 0.780780946378454 0.192390690657845 no 636 0.217465671148776 1042 9561992 SGTC_2412 st077135 33.4 µM 0.779673911611654 0.19271695817486 no 637 0.217791419242777 1046 13258915 SGTC_778 3456-2434 196 µM 0.779273945873053 0.192834919975841 no 638 0.217909179466091 1138 5539063 SGTC_558 k064-0027 21.3 µM 0.778174647714932 0.193159362867906 no 639 0.218233030260568 1066 5088526 SGTC_2025 5147754 141 µM 0.777017369671172 0.193501277549257 no 640 0.218574261265275 1062 315777 YLR208W SEC13 SGTC_2056 5235370 200 µM 0.776341327694016 0.193701183045592 no 641 0.21877373872067 1015 5511916 SGTC_3242 9133940 49.47 µM 0.772931008616147 0.19471153226403 no 642 0.219781606041294 1136 17248444 SGTC_1446 4239-0190 62 µM 0.771844222948583 0.195034178408494 no 643 0.220103347989821 1070 1340085 SGTC_746 1095-0025 46.6 µM 0.77087451828665 0.195322339626886 no 644 0.220390656148832 1095 6749286 SGTC_95 0471-0001 561.058 µM 0.770198981334541 0.195523237603569 no 645 0.220590934043791 1062 4015405 SGTC_709 3807-1509 243 µM 0.769801500451589 0.195641503084692 no 646 0.220708824766702 1092 1886677 YPL242C IQG1 SGTC_1143 3454-2408 5.08 µM 0.767690699581093 0.196270272953997 no 647 0.22133548144093 1053 X1143 SGTC_2817 7995342 71.43 µM 0.765716414294049 0.196859484745655 no 648 0.221922529071914 1057 18879975 SGTC_2185 6113692 200 µM 0.765702643536384 0.19686359829063 no 649 0.221926626884269 1069 874150 SGTC_1192 1488-0095 21.4 µM 0.764329685121787 0.197273984087434 no 650 0.222335399759987 1045 915875 SGTC_425 3825-7017 13.1 µM 0.763649493781106 0.197477489062194 no 651 0.222538073106863 1087 3397440 SGTC_810 3825-7150 143 µM 0.761705521033508 0.198059801466066 no 652 0.22311788972445 1151 22330411 YGL099W LSG1 SGTC_1117 retinoic acid 1.10837 µM 0.76062393083515 0.198384237696523 no 653 0.223440860945187 1122 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_174 3553-0389 74.3 µM 0.760212234488568 0.198507815276735 no 654 0.223563866521269 1062 738071 SGTC_3106 9121286 49.47 µM 0.759259827809771 0.198793874073818 no 655 0.22384857169295 1096 15943471 SGTC_1523 st012844 44.7 µM 0.758911444426969 0.198898574333523 no 656 0.223952766210293 1078 4274103 SGTC_1273 0849-0096 14.1 µM 0.758536510397577 0.199011291029443 no 657 0.224064932277522 1085 5286025 SGTC_3 0833-0587 95.581 µM 0.757569998267957 0.199302031736378 no 658 0.224354223227975 1063 5382644 SGTC_204 PMA1.184 62.41 µM 0.756964528889801 0.199484295840986 no 659 0.224535556858104 1156 2252213 YGL008C PMA1 SGTC_1312 1218-2183 165 µM 0.756880349068172 0.199509644387165 no 660 0.224560774678969 1130 6744073 SGTC_2431 5490079 200 µM 0.756722937180516 0.199557050051977 no 661 0.224607935003687 1156 5722345 SGTC_396 dithiazanine 1.25 µM 0.756308060551908 0.199682025456687 no 662 0.224732258226435 1065 10578 An antihelmenthic. SGTC_327 1273-0057 3.96 µM 0.755343477249811 0.199972773771925 no 663 0.225021459053608 1053 3108138 SGTC_824 1304-0008 100 µM 0.754865565148275 0.200116922082712 no 664 0.225164824490222 1087 768245 SGTC_2109 5483026 200 µM 0.75417130246686 0.200326437498278 no 665 0.225373183545137 1106 759335 SGTC_3065 9113888 49.47 µM 0.751511586346471 0.201130308508704 no 666 0.226172415246817 1103 16648368 SGTC_2046 4110841 106 µM 0.750321551371885 0.201490609503768 no 667 0.226530532899234 1123 44119630 YMR134W ERG29 SGTC_522 1273-0010 11.6 µM 0.749741474178101 0.201666376722589 no 668 0.226705211726154 1141 5705015 SGTC_2980 9014342 25.29 µM 0.748932904942114 0.201911531709838 no 669 0.226948823204283 1084 2996599 SGTC_1380 2291-0730 164 µM 0.74791950809097 0.202219041416389 no 670 0.227254354966288 1114 2999191 SGTC_3058 9093861 49.47 µM 0.747893999512272 0.202226785467629 no 671 0.227262048606382 1111 17217477 SGTC_68 0986-0284 82.829 µM 0.74774614349828 0.202271676000209 no 672 0.227306646336276 999 423278 YIL048W NEO1 SGTC_2004 4023728 41.89 µM 0.746166825175997 0.202751544259007 no 673 0.227783322814203 1114 360084 YDR527W RBA50 SGTC_3096 9117468 49.47 µM 0.74355197979624 0.203547546252344 no 674 0.228573781839801 1036 41316311 SGTC_820 1582-0060 59.9 µM 0.743272147822544 0.203632841980642 no 675 0.228658465277867 1100 3848840 SGTC_1190 1486-1332 13 µM 0.742773202083535 0.203784978759787 no 676 0.228809501163953 1124 4150046 SGTC_3129 9127257 49.47 µM 0.74038223733205 0.204514963086059 no 677 0.22953404685659 1052 837894 SGTC_1843 st055809 45.5 µM 0.740373542038962 0.20451762067868 no 678 0.229536684177545 1084 16413835 SGTC_1433 4060-0023 7.6 µM 0.739868546390868 0.204672000667485 no 679 0.229689880720816 1137 3840627 SGTC_2947 9072639 7.68 µM 0.737107447322129 0.205517309045108 no 680 0.230528505308634 1165 16488146 SGTC_2165 5727197 32.143 µM 0.736843047581287 0.205598363432155 no 681 0.230608900738779 1223 1361712 SGTC_205 1486-1330 71.903 µM 0.735717544581647 0.20594360990757 no 682 0.230951305116962 1095 4118834 SGTC_984 1492-0255 2.91 µM 0.734308782512274 0.20637622995137 no 683 0.231380283224495 1070 1585198 SGTC_685 1278-0033 54.9 µM 0.733793728996679 0.206534533280348 no 684 0.231537231555249 1151 3590572 SGTC_1649 st011737 51.3 µM 0.733469736429176 0.206634150265717 no 685 0.231635989739701 1098 1761035 SGTC_1383 3049-0032 20.7 µM 0.732998156563085 0.206779196296877 no 686 0.231779776867598 1167 712864 SGTC_702 1488-0190 94 µM 0.731509643916346 0.207237420339042 no 687 0.232233958056756 1138 949357 SGTC_3240 9133527 49.47 µM 0.731486598510634 0.20724451935889 no 688 0.23224099365797 1107 17617455 SGTC_224 benfluorex 43.875 µM 0.731352254740898 0.207285906135592 no 689 0.232282010232352 1150 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1331 1472-0049 76.2 µM 0.72973142777491 0.20778561322442 no 690 0.232777183380503 1127 24051409 SGTC_253 dyclonine 31.25 µM 0.729167620472096 0.207959603810381 no 691 0.232949567577266 1201 3180 An oral anasthetic. SGTC_2116 5511452 16.8835 µM 0.728861212340734 0.208054197236027 no 692 0.233043281655995 1124 870744 SGTC_262 fenpropimorph 62.5 µM 0.727582026817574 0.208449377914795 no 693 0.233434743056029 1084 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.726150577943434 0.208892121947455 no 694 0.233873232844781 1170 688761 SGTC_756 0508-1999 28.3 µM 0.725485394208408 0.209098050228341 no 695 0.234077151033839 1149 6753853 SGTC_2700 st077718 96.8 µM 0.724451911270065 0.209418233996614 no 696 0.234394169981002 1131 904970 SGTC_3049 9092223 49.47 µM 0.724334916970321 0.209454498216523 no 697 0.23443007272657 1100 8623917 SGTC_443 clozapine 122 µM 0.724229693369061 0.20948711707926 no 698 0.234462365925852 1067 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_605 1315-0399 119 µM 0.724125167710946 0.209519522541277 no 699 0.234494447362478 1177 24020461 SGTC_2426 5582046 32.21 µM 0.724103723765805 0.209526171043322 no 700 0.234501029324821 1152 2251934 SGTC_1269 0831-0796 3.05 µM 0.723940540059955 0.20957676874697 no 701 0.234551119958518 1147 927758 SGTC_1350 1495-0454 146 µM 0.721172967852387 0.210435992525251 no 702 0.235401550668211 1168 1069057 SGTC_1496 4469-0713 57.4 µM 0.720469332747323 0.210654773165931 no 703 0.235618037516062 1143 746691 SGTC_852 0418-0143 439 µM 0.719733230409297 0.210883791580654 no 704 0.235844631020612 1196 5369229 SGTC_132 0417-1715 25.805 µM 0.718886454973676 0.211147423442237 no 705 0.236105441407906 1179 6769098 SGTC_1655 st012546 55.1 µM 0.718796236121366 0.211175523219104 no 706 0.236133238556239 1132 720985 YLR208W SEC13 SGTC_2198 6589944 200 µM 0.718603437101962 0.211235580201798 no 707 0.236192647514921 1096 5290268 SGTC_2645 abamectin 100 µM 0.718102539027408 0.21139165694569 no 708 0.236347032377175 1154 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_886 0866-0150 153 µM 0.716602127522434 0.211859579886223 no 709 0.236809815682907 1185 271463 SGTC_2940 9060638 45.86 µM 0.7160667469663 0.212026691887504 no 710 0.236975067712712 1145 4027022 SGTC_3155 9099265 49.47 µM 0.715267719907589 0.212276241002283 no 711 0.237221815440627 1102 25236499 SGTC_3353 9151644 39.2805 µM 0.715069607451117 0.212338141284683 no 712 0.237283016419784 1159 4909158 SGTC_3152 9099253 49.47 µM 0.71298478100139 0.212990185089819 no 713 0.237927587339197 1189 25236131 SGTC_936 3005-4620 401 µM 0.708283823498257 0.214464721711927 no 714 0.239384510324303 1188 777207 SGTC_1920 st075728 45.7 µM 0.707616091360878 0.21467464780957 no 715 0.239591848671746 1167 3400306 SGTC_2847 9005661 71.43 µM 0.707007211369037 0.214866175628187 no 716 0.239780998182317 1083 2991449 SGTC_2649 anisomycin 9.56 µM 0.707001533924422 0.214867961978404 no 717 0.239782762272561 1150 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2986 9022445 71.43 µM 0.70636808715632 0.215067323734109 no 718 0.239979630717933 1147 6459286 SGTC_815 1582-0027 36.9 µM 0.706251779252304 0.215103940446519 no 719 0.240015787539234 1204 3128206 SGTC_1175 0741-0056 27.6 µM 0.705483352033513 0.215345951983878 no 720 0.240254744342779 1235 765927 SGTC_2010 4012422 159 µM 0.704878257159739 0.215536634115222 no 721 0.240443001095569 1148 952393 SGTC_2959 9079155 11 µM 0.701868075830643 0.216486679616828 no 722 0.241380719756066 1180 16189457 SGTC_2783 7738165 71.43 µM 0.70135666193646 0.216648327794632 no 723 0.241540230412993 1131 17201110 SGTC_389 tpck 16.7 µM 0.700985007873128 0.216765844346409 no 724 0.241656185702131 1174 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3238 9133470 49.47 µM 0.699965858299699 0.217088287235381 no 725 0.241974313230676 1190 3534688 SGTC_1631 benzylvanillin 81.9 µM 0.699414452248732 0.217262858906309 no 726 0.242146529277708 1183 75506 SGTC_1921 5740136 50 µM 0.697894626739881 0.217744445561952 no 727 0.242621547490107 1192 1774243 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.697806797402111 0.217772294827564 no 728 0.242649013774941 1188 97141 SGTC_105 0111-0055 734.78 µM 0.697571814024723 0.217846814365946 no 729 0.242722506840754 1128 5179370 SGTC_328 k915-0120 63.5 µM 0.696312179861042 0.218246528821947 no 730 0.243116673562229 1169 6624543 SGTC_3084 9116877 49.47 µM 0.693641088285585 0.219095531893347 no 731 0.243953659734484 1122 27241325 SGTC_2594 a-mangostin 100 µM 0.692354909199318 0.219505018726408 no 732 0.244357237610883 1216 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.691478857783164 0.219784182822664 no 733 0.244632331305338 1221 688788 SGTC_523 1934-0222 13.7 µM 0.691281583612185 0.219847074662627 no 734 0.244694301445157 1211 1361595 SGTC_770 0389-1121 67.2 µM 0.690276017880077 0.220167813743725 no 735 0.245010313180046 1254 6753108 SGTC_2148 5546263 113.568 µM 0.689687508813742 0.220355651262903 no 736 0.24519536138802 1181 792097 SGTC_532 1548-0774 215 µM 0.688409254135692 0.220763954806975 no 737 0.245597548924589 1292 5932993 SGTC_104 0074-0074 590.992 µM 0.687955971968004 0.220908847409963 no 738 0.245740253790978 1078 3943124 SGTC_2011 4012611 177 µM 0.687508721134732 0.221051865427807 no 739 0.245881103461857 1231 2049887 SGTC_3334 9142812 21.919 µM 0.687250620068227 0.221134422869348 no 740 0.24596240519209 1218 45283678 SGTC_1766 st045414 44.774 µM 0.685511195774423 0.221691263307953 no 741 0.246510699113759 1259 253960 SGTC_1988 st071872 53.4 µM 0.684239075935096 0.222099012693502 no 742 0.246912105524789 1224 16414116 SGTC_1724 st037281 8.293 µM 0.683734150333233 0.222260973833122 no 743 0.247071527355586 1227 574124 YDL195W SEC31 SGTC_1459 k035-0031 35.7 µM 0.683188584386109 0.222436046586101 no 744 0.247243842568154 1112 3877128 YMR208W ERG12 SGTC_2891 9063876 19.48 µM 0.682435617615704 0.222677803641382 no 745 0.247481770154605 1182 6472478 SGTC_1567 st069303 68.4 µM 0.681485575446402 0.222983049812813 no 746 0.247782145454187 1251 5581319 SGTC_1726 st035556 14.5795 µM 0.681483821713952 0.222983613502945 no 747 0.247782700112568 1246 5919439 SGTC_1853 st056710 91.2 µM 0.681174121410205 0.223083171062969 no 748 0.247880660378685 1282 269167 SGTC_1047 2043-3044 82 µM 0.681152108008303 0.223090248546939 no 749 0.247887624150935 1219 669592 SGTC_1710 st031758 61.5 µM 0.680833594009799 0.223192667640827 no 750 0.247988395316455 1231 5394341 SGTC_1124 fisetin 1.16336 µM 0.679736630977866 0.223545604028938 no 751 0.24833561868394 1206 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_643 k048-0106 28.4 µM 0.678399166258256 0.22397634846355 no 752 0.248759318795836 1237 6763920 SGTC_1373 2887-0003 58.5 µM 0.678160402291171 0.224053294461246 no 753 0.248834998136396 1209 776948 SGTC_1731 st035964 63 µM 0.67753230595121 0.224255781535428 no 754 0.249034139945658 1204 6739575 SGTC_2237 6667747 47.222 µM 0.67686466457194 0.224471131100009 no 755 0.249245912689037 1165 729940 YDL015C TSC13 SGTC_3332 9141069 11.198 µM 0.67590321373357 0.224781455795763 no 756 0.249551048592629 1193 17332883 SGTC_2345 9052315 157.45 µM 0.675523999742743 0.224903920458845 no 757 0.249671454390852 1226 6469265 SGTC_2965 9082772 38.63 µM 0.674490759476595 0.225237790451022 no 758 0.249999679274407 1253 16459634 SGTC_917 harmaline 728.087 nM 0.673781419045292 0.225467161402338 no 759 0.250225144805143 1208 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2960 9079389 5.97 µM 0.672578435736887 0.225856457859676 no 760 0.25060776225608 1218 16457355 SGTC_2997 9067075 71.4286 µM 0.669399210566633 0.226887111967643 no 761 0.251620427534694 1233 27209819 SGTC_64 000l-0018 272.079 µM 0.669292927361735 0.226921613052847 no 762 0.251654318777685 1192 6811119 SGTC_2064 5220758 200 µM 0.667967184551717 0.227352217162544 no 763 0.252077269866512 1284 788518 SGTC_411 enrofloxacin 100 µM 0.667378234349687 0.227543657035159 no 764 0.252265282595656 1295 71188 A bacterial gyrase inhibitor. SGTC_3127 9126946 49.47 µM 0.666427075078223 0.227853025557533 no 765 0.252569080714129 1190 27243249 SGTC_401 neomycin 50 µM 0.666013460258513 0.227987629306238 no 766 0.252701248456831 1214 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_919 tnp00227 403.569 nM 0.665809819549603 0.228053917061368 no 767 0.252766333809076 1252 1269246 A methoxyflavone. YNL221C POP1 SGTC_1882 5615643 20 µM 0.665597430462449 0.228123064076244 no 768 0.252834224621626 1184 2253075 SGTC_2669 eugenol 100 µM 0.664685467316096 0.22842010372144 no 769 0.253125845458177 1226 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2413 inermin 26.06 µM 0.663383541840225 0.228844536104891 no 770 0.253542471942191 1333 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_973 1325-0077 65.9 µM 0.66296474198827 0.228981160401482 no 771 0.253676567761911 1278 2835149 SGTC_3261 9137475 49.47 µM 0.662532858276046 0.229122100942534 no 772 0.2538148919119 1141 17027690 SGTC_1131 3454-3128 32.3 µM 0.661963059820964 0.229308122879602 no 773 0.2539974480972 1307 710982 SGTC_2743 auranofin 4.32 µM 0.661799618538998 0.229361497130377 no 774 0.254049825319439 1196 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3270 9137563 49.47 µM 0.66167141191937 0.229403369836613 no 775 0.254090915028349 1219 17015724 SGTC_2050 5263056 171 µM 0.661307751029815 0.22952216599688 no 776 0.254207485854934 1250 763468 YGL055W OLE1 SGTC_597 k018-0003 82.8 µM 0.659943626591009 0.229968088014326 no 777 0.25464500319427 1327 6786234 SGTC_2155 5570423 76 µM 0.658026766466214 0.230595513770908 no 778 0.255260465935884 1226 797402 SGTC_2985 9022375 71.43 µM 0.657648480736603 0.230719446994622 no 779 0.255382017200211 1291 4939335 SGTC_276 colchicine 750 µM 0.657547637483649 0.230752491342509 no 780 0.255414425391981 1291 2833 A microtubule depolymerizer. SGTC_556 4058-0063 51.5 µM 0.654522734686487 0.231744920472193 no 781 0.256387542471873 1307 6615692 SGTC_1239 0337-0584 35.4 µM 0.652469210583288 0.232420006504057 no 782 0.257049264482319 1323 914301 YML130C ERO1 SGTC_2483 5729050 27.16 µM 0.651916323449462 0.232601952163843 no 783 0.257227576984201 1305 2865180 SGTC_1855 st056195 39.6 µM 0.65005576056033 0.233214812660875 no 784 0.257828102012489 1238 4028379 SGTC_446 go6976 132 µM 0.650030478180243 0.233223146723442 no 785 0.257836267293579 1241 3501 A protein kinase C inhibitor. SGTC_3139 9095020 49.47 µM 0.648591915151006 0.233697625637091 no 786 0.258301091321712 1094 25236292 SGTC_29 0299-0004 12.984 µM 0.648237016276137 0.233814763597962 no 787 0.258415831894757 1170 16871 A napthoquinone isolated from Swertia calycina. SGTC_111 0083-0039 52.457 µM 0.648112927120699 0.233855728154241 no 788 0.258455956765985 1188 759313 SGTC_2469 5655019 90.81 µM 0.646611559555548 0.23435167760113 no 789 0.258941687369774 1341 2788239 SGTC_2219 9098279 200 µM 0.645453239253073 0.234734705063775 no 790 0.259316755887527 1263 902349 SGTC_48 0382-0018 55 µM 0.641535505042315 0.236032762958511 no 791 0.260587410318625 1373 762596 SGTC_85 0868-0259 160.055 µM 0.641447113092258 0.236062095305576 no 792 0.26061611576344 1250 83173 SGTC_3105 9121040 49.47 µM 0.641280660834118 0.236117336956886 no 793 0.260670175851987 1147 41448907 SGTC_2856 9022925 19.48 µM 0.641039676353858 0.236197326744427 no 794 0.260748452617219 1283 4944862 SGTC_2805 7950783 58.44 µM 0.640844866711204 0.236262000662507 no 795 0.260811739675544 1284 1178958 YDL195W SEC31 SGTC_598 3937-0236 20.2 µM 0.64065239123879 0.236325909246638 no 796 0.26087427620096 1310 1379313 SGTC_3209 9113616 49.47 µM 0.639845403722034 0.236593960890185 no 797 0.261136555594955 1302 16649353 SGTC_1298 1079-1278 263 µM 0.639244675217434 0.236793609419885 no 798 0.261331886607993 1301 2840950 SGTC_846 0335-0850 148 µM 0.639153697620334 0.236823853356517 no 799 0.261361475143049 1263 6819598 SGTC_3190 9110366 49.47 µM 0.637374896581398 0.237415611714675 no 800 0.261940337992642 1221 17123768 SGTC_2401 5128683 200 µM 0.636325433934048 0.237765119577468 no 801 0.262282165389033 1236 708373 SGTC_2927 9011802 47.9 µM 0.635517067360061 0.238034526293344 no 802 0.262545619491437 1267 43912568 SGTC_987 1497-1013 404 µM 0.634747790851603 0.23829106064852 no 803 0.262796459501194 1279 1676435 SGTC_3064 1327-0027 10 µM 0.634458399334613 0.238387604621964 no 804 0.262890853870287 1193 16000455 YPR107C YTH1 SGTC_3168 9103419 49.47 µM 0.634188408650613 0.238477695589434 no 805 0.262978935661573 1243 16649256 SGTC_1734 st037168 69.4 µM 0.634088628016132 0.238510995284259 no 806 0.263011491924434 1284 708907 SGTC_3283 9109332 35.8195 µM 0.633576545875451 0.238681932009242 no 807 0.263178605659568 1224 17027281 SGTC_627 1391-0720 175 µM 0.633478699468423 0.238714601474481 no 808 0.263210543189852 1269 997839 SGTC_1529 apigenin 74 µM 0.632133474662782 0.239164000050886 no 809 0.263649831556684 1386 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2255 7941087 197.44 µM 0.629882272981242 0.239917091016941 no 810 0.264385805933939 1328 935561 SGTC_930 2810-3379 265 µM 0.629742157615338 0.239964006306374 no 811 0.264431647712844 1419 1015764 SGTC_1859 st055998 20 µM 0.62928263887362 0.240117903582898 no 812 0.26458201761305 1328 676301 SGTC_1267 0828-0272 9.49 µM 0.628624391636369 0.240338450659945 no 813 0.264797493884664 1363 745334 SGTC_2190 6049624 200 µM 0.628574602541151 0.240355137085881 no 814 0.264813795900831 1247 2265554 SGTC_2816 7982706 58.44 µM 0.62820694804348 0.240478373150376 no 815 0.264934189649754 1301 2981853 SGTC_2196 6573537 42.6665 µM 0.627599736289611 0.240681983008702 no 816 0.265133090753943 1341 2903087 SGTC_622 1348-1566 26.3 µM 0.626899133895695 0.240917025098456 no 817 0.265362677527239 1339 7340407 SGTC_2754 granisetron 64.02 µM 0.62658646282768 0.241021962053529 no 818 0.265465172108734 1325 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2097 5376186 200 µM 0.626358817400117 0.241098378801101 no 819 0.26553980764545 1265 742755 SGTC_2259 7964009 200 µM 0.625037487497494 0.241542187072175 no 820 0.265973227259331 1329 313134 SGTC_2140 5586273 200 µM 0.624010023934071 0.241887597896705 no 821 0.266310501025671 1298 854421 SGTC_1909 st060837 51.5 µM 0.623163378239232 0.242172422969925 no 822 0.266588582338418 1277 678937 SGTC_2106 5357045 167.29 µM 0.621509249542983 0.242729422395965 no 823 0.267132305288835 1345 668842 SGTC_2764 methyldopa 94.69 µM 0.620839404161142 0.242955178439251 no 824 0.267352647004764 1348 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2195 6536160 144.242 µM 0.619700415377033 0.243339309158704 no 825 0.267727521079666 1209 3834386 SGTC_1280 0880-0253 10.1 µM 0.619394708276993 0.243442466532019 no 826 0.267828183176084 1302 6836607 SGTC_41 0478-0632 82.643 µM 0.618197312563461 0.243846741458279 no 827 0.268222640681674 1302 3750424 SGTC_319 1348-1596 45.5 µM 0.61792395263789 0.243939086335333 no 828 0.268312734479674 1383 5380505 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.615813432920081 0.244652684735978 no 829 0.26900883033057 1261 1241132 A phosphatase inhibitor. SGTC_154 3389-1638 511.116 µM 0.613643078949157 0.245387684771895 no 830 0.2697256049722 1224 5238686 SGTC_237 nikkomycin 200 µM 0.61239727869182 0.245810116056465 no 831 0.270137470923709 1380 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1464 k208-0027 110 µM 0.612297058056945 0.245844116255365 no 832 0.270170617884886 1402 X1464 SGTC_1368 1852-0141 284 µM 0.611660639228857 0.246060082453969 no 833 0.270381154436933 1312 2838987 SGTC_1043 0916-0009 19.3 µM 0.610934789035315 0.246306521006738 no 834 0.270621376234703 1362 3101130 SGTC_2067 5224629 34.075 µM 0.609932571965561 0.246647008193001 no 835 0.270953237397151 1308 2835000 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.609266936944733 0.246873286257844 no 836 0.271173759301285 1203 6708630 An antioxidant. SGTC_1939 st074455 53.6 µM 0.608415382425989 0.247162928302972 no 837 0.271456005911667 1416 1644229 SGTC_2382 9035899 200 µM 0.605839473246634 0.248040186020464 no 838 0.272310677480874 1341 6462679 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.605238938335254 0.248244944137186 no 839 0.272510123450243 1329 2724278 An inhibitor of dopamine biosynthesis. SGTC_1109 tnp00067 928.257 nM 0.604491249226583 0.248500001793896 no 840 0.272758542695179 1308 676295 SGTC_106 0092-0003 11.579 µM 0.603513492962586 0.2488337523714 no 841 0.273083571051749 1340 1072148 SGTC_3157 9099274 49.47 µM 0.602404059763469 0.249212738795501 no 842 0.273452604144998 1310 17217662 SGTC_740 k014-0057 261 µM 0.601425722999061 0.249547196723587 no 843 0.273778235075098 1388 4012779 SGTC_1950 st077106 7.18 µM 0.601359213674353 0.249569942508474 no 844 0.27380037908829 1315 13831864 SGTC_2053 5265679 138 µM 0.600863801438331 0.249739405135439 no 845 0.273965352472659 1306 764595 SGTC_745 0469-0705 296 µM 0.600799004121257 0.24976157447429 no 846 0.273986933757115 1425 3486736 SGTC_842 0271-0008 11.1 µM 0.600610302810526 0.249826141483712 no 847 0.274049787081271 1393 1221709 SGTC_1854 st056233 32.9 µM 0.600103639090075 0.249999547972735 no 848 0.274218583729235 1316 5393174 SGTC_2492 derrusnin 100 µM 0.599641374527346 0.250157814478313 no 849 0.274372633436174 1274 1715307 Part of coumarin class of compounds. SGTC_1493 4348-0038 111 µM 0.599595374035512 0.250173566671683 no 850 0.274387965440931 1391 800424 SGTC_2497 7-hydroxyflavone 100 µM 0.596451445526785 0.251251404354902 no 851 0.275436840626647 1371 5281894 SGTC_1416 3966-0321 25.3 µM 0.591735563554555 0.252872749754635 no 852 0.277013838999854 1343 582530 YLR208W SEC13 SGTC_925 2064-1272 59.6 µM 0.591389018161148 0.25299211075246 no 853 0.277129898420524 1337 6815817 SGTC_1204 4049-0315 18.3 µM 0.590878386566648 0.253168042145024 no 854 0.277300954304979 1468 588402 SGTC_879 0831-1030 162 µM 0.58935806111421 0.253692230997966 no 855 0.277810551881878 1352 1549252 SGTC_1560 lithocholic acid 53.1 µM 0.588244817413358 0.254076424414569 no 856 0.278183989567441 1324 9903 A bile acid which acts as a detergent. SGTC_2024 5144227 134 µM 0.58800230196558 0.254160159799291 no 857 0.278265373854035 1372 3475211 SGTC_1024 4507-0395 26 µM 0.58795231022808 0.2541774226735 no 858 0.278282151720614 1382 4201836 SGTC_1062 mesoridazine 14.2 µM 0.586478552648381 0.254686608734301 no 859 0.278776985061609 1359 4078 A neuroleptic. SGTC_296 1222-0039 74.9 µM 0.584553007988413 0.255352692095509 no 860 0.279424156444332 1316 5984176 SGTC_2812 7970281 58.44 µM 0.583211153065941 0.255817403576748 no 861 0.279875582002066 1454 2233435 SGTC_1011 4112-3381 17.4 µM 0.583055593866417 0.255871305411743 no 862 0.279927937950761 1402 2877139 SGTC_3029 9088683 49.47 µM 0.582592587707392 0.256031773818481 no 863 0.280083798213932 1364 25236615 SGTC_2333 9017922 200 µM 0.581340848243076 0.256465863628692 no 864 0.280505377653165 1460 3163164 SGTC_2052 5265182 7.135 µM 0.579730202444993 0.257024981906504 no 865 0.281048286339908 1427 1239884 SGTC_1305 1181-0477 144 µM 0.579682056322554 0.257041705066866 no 866 0.281064523013289 1437 6252086 SGTC_1662 st014054 52 µM 0.575301295162417 0.258565691665065 no 867 0.282543772870738 1357 2838777 SGTC_1472 k841-0093 193 µM 0.574587743711745 0.258814365550164 no 868 0.282785071525332 1427 X1472 SGTC_211 3455-0679 143.504 µM 0.572620574955054 0.259500567524131 no 869 0.283450812788596 1380 748649 SGTC_2085 5307070 144.047 µM 0.572235840814887 0.259634883023816 no 870 0.283581104645447 1334 2840351 SGTC_63 0099-0242 26.702 µM 0.571033983068404 0.260054697641923 no 871 0.283988303621545 1375 3898502 YLR359W ADE13 SGTC_1420 4'-methoxyflavone 42 µM 0.569235500145802 0.260683569370133 no 872 0.28459816600558 1389 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_232 clozapine 119 µM 0.569180083284297 0.260702959289316 no 873 0.284616967692928 1381 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_564 3555-0129 330 µM 0.5677230022283 0.261213046543508 no 874 0.285111535006075 1321 563260 SGTC_2693 st077581 40.7 µM 0.567351659620258 0.261343126161097 no 875 0.285237642826689 1387 25238761 SGTC_8 0354-0001 70 µM 0.565848388292222 0.261870055009929 no 876 0.285748424633799 1425 4993152 SGTC_2009 4012297 12.05 µM 0.565568696749996 0.26196815297879 no 877 0.28584350626021 1384 45595307 SGTC_611 3453-1652 23.7 µM 0.56494974017637 0.262185310462832 no 878 0.286053975092796 1421 1560575 SGTC_2711 st079103 59.1 µM 0.563657059957383 0.26263913743147 no 879 0.28649377298556 1415 54693780 SGTC_2899 9053889 58.44 µM 0.562470257496557 0.263056147058619 no 880 0.286897831233944 1380 6470052 SGTC_403 arphamenine a 50 µM 0.562269388564913 0.263126760324023 no 881 0.286966245691543 1370 5487158 An arginine aminopeptidase inhibitor. SGTC_922 1866-0035 480 µM 0.562169353438871 0.263161930185488 no 882 0.287000319790717 1447 3156169 SGTC_1903 st060211 78.3 µM 0.561918847821192 0.263250012264121 no 883 0.287085655758315 1425 688960 SGTC_3075 9116269 49.47 µM 0.559896972983536 0.263961489003773 no 884 0.28777485679268 1425 17015205 YNL244C SUI1 SGTC_1174 0739-0097 51.1 µM 0.557085045567683 0.264952603732866 no 885 0.288734662212942 1412 728447 SGTC_725 1497-0963 19 µM 0.556488135634912 0.265163238508916 no 886 0.288938601439096 1491 3549977 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.556300454591147 0.265229484083142 no 887 0.289002738226532 1487 1377 SGTC_2937 9044753 11.33 µM 0.554912599954212 0.265719614307657 no 888 0.289477221568951 1367 6465530 YGL099W LSG1 SGTC_1296 1068-0102 11.9 µM 0.549351862160301 0.267688021314309 no 889 0.291382001284629 1438 767053 SGTC_1341 1486-1360 280 µM 0.548208788674412 0.268093558643821 no 890 0.291774274062541 1388 3976547 SGTC_1929 genistein trimethyl ether 50.5 µM 0.547714603451369 0.268268980389532 no 891 0.291943941596878 1505 136420 SGTC_71 0417-1750 47.813 µM 0.547179677417997 0.268458929028513 no 892 0.292127648350255 1542 6811472 SGTC_2605 digitonin 300 nM 0.542529621311079 0.270112976351574 no 893 0.293726853659864 1468 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1817 st052116 64.4 µM 0.541483880286861 0.270485652381604 no 894 0.294087052712575 1455 4361398 SGTC_2781 5567276 71.43 µM 0.541455745811921 0.270495682354971 no 895 0.294096746278687 1466 2853274 SGTC_1946 st076057 65.1 µM 0.540515732139853 0.270830905124144 no 896 0.294420707258472 1342 953009 SGTC_1230 0170-0365 3.77 µM 0.540425540211438 0.27086307979772 no 897 0.294451799152714 1481 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1456 k015-0012 13 µM 0.539955097053299 0.271030934549507 no 898 0.294613999747751 1523 2989616 SGTC_1438 4092-1045 4 µM 0.539073687679014 0.271345562212327 no 899 0.294918005232169 1410 1351342 SGTC_24 0417-1663 219 µM 0.538465607953894 0.271562728241169 no 900 0.295127821260118 1420 4329390 SGTC_2456 5770359 74.46 µM 0.53740766033307 0.271940763628328 no 901 0.295493026547237 1500 3118787 SGTC_3081 9117243 49.47 µM 0.536926657730083 0.272112726336808 no 902 0.295659138149172 1520 45595589 SGTC_874 0599-0792 117 µM 0.536511901629841 0.272261048723259 no 903 0.295802406336015 1490 765305 SGTC_441 propafenone 146 µM 0.535696811297023 0.272552653045961 no 904 0.296084053881765 1396 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1008 4106-0037 6 µM 0.534007519984054 0.27315750220148 no 905 0.296668165645566 1430 2905394 SGTC_3151 9099821 49.47 µM 0.533929422109491 0.273185481149023 no 906 0.296695182560389 1394 17174189 SGTC_1881 5652484 16 µM 0.533368223061736 0.273386575219721 no 907 0.29688935498984 1479 2255129 SGTC_722 3534-0461 190 µM 0.533197484364551 0.273447770439308 no 908 0.29694844137132 1410 658262 SGTC_1492 4158-0558 28.5 µM 0.532429245920958 0.273723202088942 no 909 0.29721436697029 1529 3967268 SGTC_1989 st071868 50.2 µM 0.532244629597984 0.273789411851962 no 910 0.297278288095184 1503 16414057 SGTC_573 3702-0553 84.7 µM 0.53017470421816 0.274532300049041 no 911 0.297995403885804 1422 1222756 SGTC_2342 7990637 118.86 µM 0.529404356484341 0.27480902857737 no 912 0.298262488359979 1478 2033102 YER133W GLC7 SGTC_969 1313-0238 134 µM 0.529266916112662 0.274858415110713 no 913 0.298310151269671 1466 5212874 SGTC_2366 9070441 60.58 µM 0.528337958521133 0.275192332672033 no 914 0.298632395107794 1385 6837235 SGTC_1482 3346-2049 8.48 µM 0.528318477922782 0.27519933718942 no 915 0.298639154379359 1462 3826804 SGTC_1686 st019653 115.5 µM 0.526540000670123 0.275839182728875 no 916 0.299256533548319 1513 97252 SGTC_1997 st073024 93.8 µM 0.525666254738618 0.276153799210807 no 917 0.299560056985487 1419 686268 SGTC_895 0964-0006 13.7 µM 0.524777271454209 0.276474082991518 no 918 0.299869016709494 1416 6738897 SGTC_1746 st038117 42 µM 0.524066819115187 0.276730176348064 no 919 0.300116032947442 1478 2898218 SGTC_887 0885-0007 9.62 µM 0.520776103126421 0.27791787863344 no 920 0.30126137601458 1514 5719458 SGTC_230 MPP+ 141.667 µM 0.520031163322082 0.278187091127483 no 921 0.301520927450543 1397 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3128 9127691 49.47 µM 0.518862707315366 0.278609613405055 no 922 0.301928242665601 1464 41316314 SGTC_477 mead ethanolamide 10 µM 0.518195881052299 0.278850882671015 no 923 0.302160804158492 1386 16061185 SGTC_324 1315-0088 19.6 µM 0.517947925382723 0.278940623241798 no 924 0.302247301371595 1459 6787421 SGTC_1258 0671-0043 57.1 µM 0.517224854914776 0.279202398426089 no 925 0.302499601735668 1429 4298767 SGTC_3009 9080819 71.4286 µM 0.516754642945107 0.279372694604368 no 926 0.302663723046098 1444 17027216 SGTC_58 0957-0393 9 µM 0.516481359762677 0.279471692469277 no 927 0.302759127278349 1425 6997992 SGTC_1311 1190-0148 100 µM 0.515589459862006 0.279794905056531 no 928 0.303070586704835 1546 1961333 SGTC_851 0394-0702 453 µM 0.51543155871093 0.279852145208753 no 929 0.303125742131248 1510 762646 SGTC_336 4111-0029 111 µM 0.514185080407466 0.280304200649972 no 930 0.303561298887924 1413 3131175 SGTC_2525 harmine 47.85 µM 0.513873814504315 0.280417141404734 no 931 0.303670108085602 1526 5280953 A monoamine oxidase inhibitor SGTC_1403 3909-7815 62.9 µM 0.513574552123491 0.28052574753087 no 932 0.303774737624689 1491 6615483 SGTC_1188 1403-0014 4.57 µM 0.512447576778414 0.280934923808042 no 933 0.304168900372249 1464 9614867 SGTC_3119 9125183 49.47 µM 0.511847217826658 0.281153016678137 no 934 0.304378970560932 1393 22695334 SGTC_1707 st032323 6.317 µM 0.511501741782941 0.281278555089077 no 935 0.304499884540398 1450 3132057 YMR211W DML1 SGTC_3103 9120822 49.47 µM 0.509976551551088 0.281833098964026 no 936 0.305033944747852 1522 17141819 SGTC_1432 4049-0298 68.4 µM 0.509832408187552 0.281885535282604 no 937 0.305084439456991 1538 741646 SGTC_1616 st002734 56.1 µM 0.509394181536792 0.282044981767641 no 938 0.305237976958969 1480 4026101 SGTC_3018 9082602 49.47 µM 0.508255402458569 0.282459523562465 no 939 0.305637120887802 1469 17332089 SGTC_535 2293-4129 48.2 µM 0.507865498554427 0.282601524863135 no 940 0.305773835968941 1575 396118 YIL048W NEO1 SGTC_2460 5552655 174.22 µM 0.507863764751394 0.282602156383262 no 941 0.30577444396645 1429 5401989 SGTC_10 0279-0212 42.575 µM 0.507318087364576 0.282800947519329 no 942 0.305965824758307 1462 39851 YBR002C RER2 SGTC_1335 1486-0900 202 µM 0.504174410425698 0.283947500309285 no 943 0.307069410496931 1450 X1335 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.500538074048889 0.285276502690547 no 944 0.308348126999808 1519 5393153 SGTC_281 1672-3440 14.9 µM 0.500300507537313 0.28536343114452 no 945 0.308431748391157 1521 6833000 SGTC_1153 4055-0057 267 µM 0.499771132997391 0.28555718104321 no 946 0.308618119471823 1440 882706 SGTC_2719 novobiocin 32.65 µM 0.499329458404403 0.28571888085496 no 947 0.308773652733112 1565 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_937 3122-0005 46.7 µM 0.498483044759259 0.286028879810634 no 948 0.309071808453841 1543 759535 SGTC_1610 st001799 48.1 µM 0.497636774541651 0.286338985939662 no 949 0.309370039444392 1435 621897 SGTC_343 4130-2827 29.8 µM 0.497329707408673 0.286451546659717 no 950 0.309478282917904 1468 1118244 SGTC_3194 9111903 49.47 µM 0.496625038052805 0.286709934640328 no 951 0.309726746650784 1541 17087251 SGTC_1484 3473-2379 286 µM 0.495938038029031 0.286961949969505 no 952 0.309969063968216 1551 671917 SGTC_2374 9071832 200 µM 0.494115702547739 0.287630953423859 no 953 0.310612234402423 1460 17381698 SGTC_1333 1482-0047 286 µM 0.493356771219882 0.287909784414073 no 954 0.310880260675349 1491 3811116 SGTC_3020 9089140 49.47 µM 0.492900111459335 0.288077622464123 no 955 0.311041584267587 1495 17217859 SGTC_2861 9024595 19.48 µM 0.492400553867071 0.28826127979863 no 956 0.311218103912898 1472 16482810 SGTC_1698 5-fluorocytosine 1.055 µM 0.491281386917313 0.288672930608245 no 957 0.311613721299932 1538 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3069 9117009 49.47 µM 0.488522123802083 0.289689020859192 no 958 0.312590029481698 1442 41904981 SGTC_1845 st056753 3.01 µM 0.488371043443233 0.289744704178164 no 959 0.312643524220377 1422 5375839 SGTC_940 3232-1287 54.8 µM 0.487659295938083 0.290007098758684 no 960 0.312895593827651 1484 1585493 YIL048W NEO1 SGTC_3217 9129673 49.47 µM 0.486096030069255 0.290583806898555 no 961 0.313449540751768 1494 17248312 SGTC_1677 st019204 53.9 µM 0.485480434623705 0.290811054845118 no 962 0.31366779406051 1448 3945625 SGTC_1891 st059073 26.2 µM 0.485243175480357 0.290898661576691 no 963 0.313751929375856 1640 688754 SGTC_274 sirtinol 40.1 µM 0.484910863356211 0.291021386870623 no 964 0.313869788054267 1459 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2339 9000433 200 µM 0.484783357189973 0.29106848224897 no 965 0.313915014763845 1456 2988954 SGTC_1089 terbinafine 2.25 µM 0.484252766700147 0.291264498126202 no 966 0.314103246360121 1556 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3315 9136395 68.55 µM 0.48421037758181 0.291280160582389 no 967 0.314118286356011 1556 16876844 SGTC_1180 1193-0155 285 µM 0.482658534971639 0.291853825040054 no 968 0.314669104792103 1482 2921347 SGTC_2745 rifampicin 24.3 µM 0.48224033815865 0.292008508430627 no 969 0.314817612208337 1585 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_505 gw-5074 63.9 µM 0.479898679733302 0.292875349670734 no 970 0.315649720042741 1584 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1660 st012960 28.1 µM 0.478475435539025 0.29340279284508 no 971 0.316155926939349 1501 24207266 SGTC_2634 4'-methoxyflavone 100 µM 0.47845827197561 0.293409156212286 no 972 0.316162033629599 1514 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3354 9151612 71.43 µM 0.478073074625977 0.293551984409354 no 973 0.316299097665821 1593 27261949 SGTC_2944 9067346 25.62 µM 0.477352281906794 0.29381933522544 no 974 0.316555643760245 1545 6473075 SGTC_2639 lactacystin 53 µM 0.47710748193047 0.293910160142297 no 975 0.316642793583045 1585 3870 A proteasome inhibitor. SGTC_701 4424-0219 185 µM 0.47692513024339 0.293977824128638 no 976 0.31670771816747 1612 2911779 SGTC_2014 4013930 200 µM 0.476349043340618 0.294191636039072 no 977 0.316912865521698 1479 64556 SGTC_2941 9056145 11.23 µM 0.476106375068673 0.294281722713988 no 978 0.31699929773315 1443 2119517 SGTC_2420 aureobasidin a 50 nM 0.475512934988981 0.294502081414956 no 979 0.317210707926285 1653 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1468 k284-1086 134 µM 0.475505802980713 0.294504730165718 no 980 0.317213249033115 1517 15996457 SGTC_2143 5623677 140.463 µM 0.474580827291902 0.294848349273696 no 981 0.317542887275634 1508 5375313 SGTC_3271 9137798 49.47 µM 0.472973718883888 0.295445812851853 no 982 0.318115964657464 1596 6498326 SGTC_123 0083-0120 66.675 µM 0.472506537183141 0.295619598172931 no 983 0.318282638374027 1446 16001701 SGTC_1349 flufenamic acid 69 µM 0.471636034794163 0.295943538663205 no 984 0.318593300620029 1491 3371 A non-steroidal anti-inflammatory. SGTC_3013 9080133 71.4286 µM 0.471508578859736 0.295990982579783 no 985 0.318638797417513 1596 17050193 SGTC_2129 girgensonine 121.053 µM 0.471424391511435 0.296022322207802 no 986 0.318668850516864 1598 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1794 st048918 76.9 µM 0.469728624379381 0.296653913469466 no 987 0.319274457208287 1546 672303 SGTC_1904 st060225 78 µM 0.46962580364516 0.296692229058539 no 988 0.319311192949318 1481 66595 SGTC_723 4182-0001 115 µM 0.469488709905435 0.29674331982211 no 989 0.319360176492139 1498 744821 YLR208W SEC13 SGTC_2084 5306078 60.6385 µM 0.46914522322723 0.296871344787249 no 990 0.319482918000235 1556 679340 SGTC_2048 5246248 200 µM 0.467141884673249 0.297618535798323 no 991 0.320199184631378 1558 677046 SGTC_2996 9066192 71.4286 µM 0.466317794741745 0.297926147975236 no 992 0.320494021653755 1449 6472854 SGTC_1268 0828-0275 2.46 µM 0.465848149504606 0.298101519620909 no 993 0.320662098683758 1588 745337 SGTC_1404 3909-7820 48.3 µM 0.464901017454072 0.298455334047334 no 994 0.321001170933382 1610 23741373 SGTC_246 cycloheximide 667 µM 0.46413758033738 0.298740665669754 no 995 0.321274589304649 1482 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2019 4016004 108 µM 0.46358367460991 0.298947763344124 no 996 0.321473026493511 1480 45595336 SGTC_480 am 92016 50 µM 0.463016205466441 0.299159999790103 no 997 0.321676375635746 1484 2129 K+ channel blocker. SGTC_372 0155-0182 15.9 µM 0.462301376247756 0.299427446963853 no 998 0.321932606417822 1579 771486 SGTC_2206 7254556 146.969 µM 0.461937959958408 0.299563457582155 no 999 0.322062905592284 1589 4398905 SGTC_135 0933-0004 26.348 µM 0.460583675348571 0.300070552714854 no 1000 0.322548662965101 1484 21230617 YGL099W LSG1 SGTC_2776 terbinafine 19.92 µM 0.458037032132941 0.301025161798246 no 1001 0.3234629180675 1522 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3288 9119690 36.221 µM 0.457384921612275 0.301269825369301 no 1002 0.323697200143271 1486 17595618 YKL019W RAM2 SGTC_2474 5321570 43.32 µM 0.456807642326426 0.301486487913709 no 1003 0.323904656114572 1616 2841384 SGTC_1498 4478-3555 97.6 µM 0.456413442261433 0.30163447804877 no 1004 0.324046350628181 1569 3437919 SGTC_517 1365-0151 113 µM 0.456141869804427 0.301736450471768 no 1005 0.324143981699367 1568 768657 SGTC_3215 9129942 49.47 µM 0.455607090386539 0.301937299463283 no 1006 0.324336271775563 1605 17682944 SGTC_2747 doxorubicin 7.63 µM 0.455221726541501 0.30208206914536 no 1007 0.324474865701339 1536 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_878 0828-0289 13.7 µM 0.453758837805187 0.302631916228423 no 1008 0.325001206565797 1536 745350 YLR208W SEC13 SGTC_2722 naftopidil 47.16 µM 0.453715613297192 0.302648169580451 no 1009 0.325016763872005 1584 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_822 1487-0950 154 µM 0.453295275818761 0.302806245975334 no 1010 0.32516806707275 1574 1958375 SGTC_1810 st050138 53 µM 0.452530246161206 0.303094045662688 no 1011 0.325443518433498 1593 3444541 SGTC_742 0kpi-0133 140 µM 0.45220377267246 0.303216900320513 no 1012 0.325561095294363 1650 2728852 SGTC_548 1436-0017 110 µM 0.451927374144838 0.303320928760027 no 1013 0.325660651621695 1669 9677137 SGTC_2692 st077426 47.7 µM 0.451064624919655 0.303645745257678 no 1014 0.325971486299186 1626 25238571 SGTC_2849 9019321 12.99 µM 0.450978336992922 0.303678240343309 no 1015 0.326002581110544 1555 16489627 SGTC_2843 9000894 45.46 µM 0.450189454204168 0.303975396872865 no 1016 0.326286919851072 1486 2242070 SGTC_1552 6-methylflavone 10.6 µM 0.447506382617667 0.304987025639223 no 1017 0.327254740250155 1599 689013 SGTC_2848 9016370 25.97 µM 0.446007265888478 0.305552904901715 no 1018 0.327795998720223 1660 7894410 SGTC_2041 5107442 45.335 µM 0.445547173165287 0.30572667173653 no 1019 0.327962188574672 1643 793005 SGTC_1833 st055984 71 µM 0.444810996731019 0.306004800280644 no 1020 0.328228173344358 1560 676288 SGTC_1821 st053465 65.6 µM 0.44478569386342 0.306014361731151 no 1021 0.328237316964794 1525 675086 SGTC_1819 st053448 58.6 µM 0.443277875160157 0.306584374875796 no 1022 0.328782378444965 1592 2857616 SGTC_875 0709-0210 25.7 µM 0.443228327152116 0.306603113870663 no 1023 0.328800295747533 1609 6251364 SGTC_997 3996-0078 137 µM 0.44322743936117 0.306603449636702 no 1024 0.328800616789637 1572 735687 SGTC_2919 7978188 46.38 µM 0.442652722524565 0.306820843866692 no 1025 0.329008471839166 1683 2980291 SGTC_632 0781-2353 4.65 µM 0.442418452929967 0.306909478934526 no 1026 0.329093214162125 1593 6811515 YHR007C ERG11 SGTC_2217 6934799 96.0675 µM 0.441916242684483 0.307099526426547 no 1027 0.329274908229521 1620 675606 SGTC_1908 st060353 56.5 µM 0.440076752723978 0.307796072533174 no 1028 0.329940759291275 1747 4227716 SGTC_2271 7849410 118.62 µM 0.439292958054327 0.30809307706546 no 1029 0.330224638022776 1654 972430 SGTC_692 k241-0027 77.8 µM 0.438238455597787 0.30849285965197 no 1030 0.330606717287414 1656 3600480 SGTC_96 0929-0093 37.281 µM 0.438009593632039 0.30857965573413 no 1031 0.330689664481269 1530 6991579 SGTC_92 0063-0024 660.874 µM 0.437808164790222 0.308656056633086 no 1032 0.330762675878021 1566 3594437 SGTC_2902 5787006 60.46 µM 0.43639344433312 0.309192885901306 no 1033 0.331275647269441 1543 591003 SGTC_786 4544-0069 423 µM 0.431795238784525 0.310940530280519 no 1034 0.332945120143615 1638 748821 YLR208W SEC13 SGTC_157 1348-1695 65.819 µM 0.431762478627474 0.310952996838768 no 1035 0.332957026328797 1554 5380510 SGTC_808 0711-0032 135 µM 0.429905292512027 0.311660085327742 no 1036 0.33363226769825 1712 4252555 SGTC_1422 4031-0024 15.5 µM 0.429054712230887 0.311984159897326 no 1037 0.333941704447285 1585 782427 SGTC_3004 9076122 71.4286 µM 0.428074791604697 0.312357694150051 no 1038 0.334298334556334 1653 44782551 SGTC_3289 9119912 71.43 µM 0.425759039415353 0.313241197865411 no 1039 0.335141718320986 1595 17014829 SGTC_2651 TUB2.036 5 µM 0.425744833696871 0.313246620934947 no 1040 0.33514689453397 1658 15992207 YFL037W TUB2 SGTC_310 1273-0058 1.06 µM 0.425302683423083 0.313415433124644 no 1041 0.335308018820922 1562 2734232 SGTC_3264 9137442 49.47 µM 0.424703306084819 0.31364433674489 no 1042 0.335526486706845 1666 17015726 SGTC_2652 actinonin 100 µM 0.42384975469936 0.313970433895375 no 1043 0.335837694831909 1601 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_374 0880-0231 82.3 µM 0.423650527310957 0.314046569144545 no 1044 0.335910350121901 1611 6833587 SGTC_3100 9120536 49.47 µM 0.422976199182768 0.314304324061192 no 1045 0.33615631313688 1612 16421196 SGTC_3316 9136639 10.545 µM 0.421346692735456 0.314927559658294 no 1046 0.336750969493939 1669 4903665 SGTC_298 1391-0729 10 µM 0.418654369476064 0.315958444635815 no 1047 0.337734374219245 1588 3237558 SGTC_1907 st060210 83.7 µM 0.417231851768567 0.316503702804599 no 1048 0.338254414769308 1673 688793 SGTC_3352 9151559 45.5865 µM 0.416256648312734 0.316877733829448 no 1049 0.338611105701608 1555 17159339 SGTC_101 0490-5701 117.494 µM 0.415192604723396 0.317286052342754 no 1050 0.339000456051902 1687 4661669 SGTC_421 streptovitacin 30 mM 0.41481597212885 0.317430635534273 no 1051 0.339138313110929 1604 91467 include heat shock SGTC_1720 st037298 9.481 µM 0.41475836901462 0.317452750899544 no 1052 0.339159399207668 1584 597396 SGTC_2104 5389443 200 µM 0.414385092215222 0.317596077565448 no 1053 0.339296052476876 1690 2244536 SGTC_866 0495-0101 262 µM 0.413054218376083 0.318107314098035 no 1054 0.33978344531957 1540 635694 SGTC_1503 4585-0012 61.3 µM 0.41288351862725 0.318172911123843 no 1055 0.339845978417348 1672 2922052 SGTC_3310 9130229 44.1445 µM 0.412827779129246 0.318194332105319 no 1056 0.339866398637406 1674 7761258 SGTC_2619 obliquin 87.91 µM 0.412679558706434 0.31825129694948 no 1057 0.339920701621415 1695 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3343 9148379 18.9835 µM 0.412596766111063 0.318283118101755 no 1058 0.339951035493221 1746 1955036 SGTC_2825 7998094 58.44 µM 0.411320225731705 0.318773923210725 no 1059 0.340418870356912 1618 2987815 SGTC_1106 tegaserod maleate 11.7 µM 0.410108951068809 0.319239929021342 no 1060 0.34086301341078 1654 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_377 3970-0964 33.1 µM 0.409643186844991 0.31941919555879 no 1061 0.341033855865078 1657 16481235 SGTC_1571 st070080 73.4 µM 0.409307321350997 0.319548491979942 no 1062 0.34115707165839 1711 4315245 SGTC_2293 7624732 200 µM 0.40745034645586 0.320263757734567 no 1063 0.341838627885936 1534 894453 SGTC_272 doxorubicin 8.13 µM 0.406365846819604 0.320681792389735 no 1064 0.342236905116185 1610 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1570 verbenone 133 µM 0.405653660579352 0.320956437750417 no 1065 0.342498547582572 1736 29025 A natural terpanoid with antifungal properties. SGTC_1018 4259-0013 28.1 µM 0.404823650743086 0.32127664389991 no 1066 0.342803571383815 1647 6801262 SGTC_1276 0871-0068 94.2 µM 0.404408557843043 0.321436830783677 no 1067 0.342956154079455 1696 3414906 SGTC_312 4092-0653 6.84 µM 0.404190226337731 0.321521099575961 no 1068 0.343036420153392 1683 1148278 SGTC_1177 0983-0204 23.6 µM 0.403257018036026 0.321881390834078 no 1069 0.34337957901418 1761 766818 SGTC_2563 tomatine 8.54 µM 0.402826540518618 0.322047645243965 no 1070 0.343537917525917 1866 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1651 st011928 86.1 µM 0.402650848208883 0.322115509480735 no 1071 0.343602548673977 1626 720198 SGTC_2973 9094665 17.96 µM 0.402552649163798 0.322153443168827 no 1072 0.343638674711759 1738 25237061 YIL048W NEO1 SGTC_2529 gangaleoidin 93.61 µM 0.402525207617792 0.322164044000748 no 1073 0.343648770323163 1634 4565183 SGTC_798 1287-0182 476 µM 0.401426206552544 0.322588713464353 no 1074 0.344053179069056 1751 1649755 SGTC_364 0083-0097 67.7 µM 0.40081983459063 0.32282312327651 no 1075 0.344276387323352 1641 5207356 SGTC_3091 9116372 49.47 µM 0.399780067832133 0.323225237655984 no 1076 0.344659256402102 1637 17169793 SGTC_2159 5658611 73.75 µM 0.399624603920312 0.323285378787438 no 1077 0.344716515933373 1710 793844 SGTC_2803 7707263 71.43 µM 0.399185078599045 0.323455433905277 no 1078 0.344878418493843 1593 2199229 SGTC_2407 paclitaxel 400 µM 0.399119644346484 0.323480753985206 no 1079 0.344902524138317 1741 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2608 thymoquinone 42.66 µM 0.397471993489617 0.324118589096258 no 1080 0.34550971757767 1585 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_884 0851-0618 334 µM 0.394578744256297 0.325239866866032 no 1081 0.346576901466159 1729 9642473 SGTC_2205 7238770 200 µM 0.394366801275766 0.325322067690365 no 1082 0.346655125298282 1690 279867 SGTC_2177 5811945 192 µM 0.393264257040344 0.325749819949535 no 1083 0.347062157302928 1713 5343475 SGTC_2281 7943571 200 µM 0.392889297019458 0.32589534489485 no 1084 0.34720062349494 1767 1244024 SGTC_1597 7-benzyloxygramine 47.5 µM 0.391920727391498 0.326271377138781 no 1085 0.347558393723172 1600 260807 SGTC_1578 josamycin 24.2 µM 0.390901464635888 0.326667281000465 no 1086 0.347935035658861 1575 5282165 A P450 substrate. SGTC_1799 st045822 46.1415 µM 0.39079528294305 0.326708535521391 no 1087 0.347974280969027 1750 3674992 SGTC_2505 galangin 7.89 µM 0.390596509954832 0.326785770014003 no 1088 0.348047752884772 1595 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2428 5615643 7.78 µM 0.390347386885274 0.326882578827421 no 1089 0.348139843618109 1680 2253075 SGTC_1009 4106-0057 9.87 µM 0.390313547319429 0.326895729725936 no 1090 0.348152353429341 1705 2928005 SGTC_650 1328-0195 38 µM 0.390000892725712 0.327017245260368 no 1091 0.348267943398665 1723 2780821 SGTC_1220 1838-0075 193 µM 0.389921807592276 0.327047985193139 no 1092 0.34829718380262 1676 5529645 SGTC_3136 9095672 49.47 µM 0.389670681990989 0.327145604036351 no 1093 0.348390039265893 1755 17217380 SGTC_2101 5377231 179.231 µM 0.389230648870422 0.327316684501195 no 1094 0.348552766525864 1730 2844213 SGTC_1838 st055369 84.5 µM 0.388849299797141 0.327464978543127 no 1095 0.348693814569781 1607 676036 SGTC_624 k048-0052 28 µM 0.388086983928171 0.327761499569199 no 1096 0.348975831947912 1645 6835531 SGTC_2115 tiliquinol 12.7705 µM 0.386598882625335 0.328340645129994 no 1097 0.349526592644488 1655 71208 A bioactive hydroxyquinoline. SGTC_457 grayanotoxin iii 135 µM 0.38585881180418 0.328628822799041 no 1098 0.349800618090861 1643 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1759 st043059 70 µM 0.385745244724769 0.328673053939824 no 1099 0.349842675414413 1586 669426 SGTC_2837 9008476 45.46 µM 0.385454526674903 0.328786291270439 no 1100 0.34995034549309 1692 2992805 SGTC_2156 5649887 115 µM 0.385317509481012 0.32883966616757 no 1101 0.350001095243276 1741 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2912 7964298 10.93 µM 0.384918386044401 0.328995164155378 no 1102 0.350148941699648 1627 2975850 SGTC_120 rhodamine 6G 52.259 µM 0.384617745647708 0.329112312821016 no 1103 0.350260322290892 1612 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_233 rapamycin 362 pM 0.384550278265715 0.329138604720646 no 1104 0.350285319227629 1678 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3150 9097574 49.47 µM 0.384016280243118 0.329346732457126 no 1105 0.350483190518509 1773 17217476 SGTC_576 1073-0113 22.7 µM 0.383624764713719 0.329499360713857 no 1106 0.350628291154887 1721 5439563 SGTC_3011 9081274 71.4286 µM 0.383036185429721 0.329728865675488 no 1107 0.35084646713115 1630 6625322 SGTC_478 N-arachidonylglycine 10 µM 0.383011652024177 0.329738433389167 no 1108 0.350855562300993 1693 5283389 SGTC_2160 5660466 132.927 µM 0.382891113193853 0.329785443606275 no 1109 0.350900250413639 1747 2859134 SGTC_2840 9008771 71.43 µM 0.382355853491852 0.329994227688277 no 1110 0.351098715489623 1798 2992978 SGTC_1240 0356-0016 42.1 µM 0.382221444418959 0.330046663785053 no 1111 0.351148558441164 1692 4305613 SGTC_196 k015-0023 18.111 µM 0.382015120649237 0.330127161969419 no 1112 0.351225074520565 1646 5211998 SGTC_408 cantharidin 100 µM 0.381697623324125 0.330251050398568 no 1113 0.351342831583346 1679 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1664 st014217 9.02 µM 0.38022575520276 0.330825620799366 no 1114 0.351888921251198 1713 3982782 SGTC_3277 9138724 49.47 µM 0.378708970775153 0.331418142345004 no 1115 0.352451995505464 1666 15943418 SGTC_7 0192-1582 4.227 µM 0.37830700594021 0.331575238011838 no 1116 0.352601270756171 1681 252616 SGTC_55 0767-0285 6.563 µM 0.378240213636397 0.331601344613366 no 1117 0.352626077210295 1781 3116166 SGTC_3133 9127736 49.47 µM 0.37746932257534 0.331902716136862 no 1118 0.352912429089264 1823 27243420 SGTC_2741 miltefosine 3.04 µM 0.37740891668367 0.3319263357659 no 1119 0.352934870724883 1672 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2642 cholecalciferol 100 µM 0.377284802935833 0.331974868238757 no 1120 0.3529809823277 1718 9821465 A vitamin D precursor, similar to steriods. SGTC_479 n-linoleoylglycine 10 µM 0.376373233185569 0.332331407717078 no 1121 0.353319721191194 1659 6433346 An anti-infammatory. SGTC_658 3253-0951 102 µM 0.376085792592851 0.332443864966585 no 1122 0.353426558088314 1671 1184878 SGTC_2451 5856223 45.7 µM 0.374571923521448 0.333036394520576 no 1123 0.353989428518885 1609 2179896 SGTC_2262 9014885 67.46 µM 0.373995451072295 0.333262136028898 no 1124 0.354203850267678 1783 6457424 SGTC_2832 7992762 51.95 µM 0.373344048094497 0.33351729237104 no 1125 0.354446198428886 1485 2985177 SGTC_334 1502-1024 68.5 µM 0.372182642317176 0.333972409277314 no 1126 0.354878434366054 1685 3296216 SGTC_3183 9108214 49.47 µM 0.372022956401825 0.334035004078808 no 1127 0.354937878686056 1684 4974831 SGTC_1889 st059080 5.18 µM 0.371396391015055 0.334280654146108 no 1128 0.355171156609955 1805 176925 Isolated from Daphnopsis sellowiana. SGTC_1615 st002656 86.5 µM 0.370615637258677 0.33458685435893 no 1129 0.355461916707769 1643 1584458 SGTC_1061 3448-9325 110 µM 0.370399389562939 0.33467168301518 no 1130 0.355542464286227 1703 723482 SGTC_2616 abietic acid 100 µM 0.370263768763306 0.334724888027895 no 1131 0.355592983386108 1813 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1434 4073-0095 163 µM 0.369776516982809 0.334916067768214 no 1132 0.35577450686357 1709 24133745 SGTC_70 0141-0289 43.283 µM 0.369025127711428 0.335210969235684 no 1133 0.356054497683753 1750 352408 SGTC_417 st075190 100 µM 0.368661099569069 0.335353877707295 no 1134 0.356190173728408 1786 222757 SGTC_2629 bisabolol 100 µM 0.367887515507744 0.335657646833797 no 1135 0.356478554809329 1746 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_787 4152-0075 138 µM 0.366349195331449 0.336262029769825 no 1136 0.357052262343136 1706 9566539 SGTC_1057 3448-5381 134 µM 0.364830533906605 0.336859104480045 no 1137 0.357618955503169 1772 5497911 SGTC_1132 3456-3614 2.5 µM 0.363305523402155 0.337459089379248 no 1138 0.358188333877956 1873 3125502 SGTC_2348 9022543 33.42 µM 0.36320205585271 0.337499811613426 no 1139 0.358226975996678 1713 3162678 YDL140C RPO21 SGTC_2688 kanamycin b 96.69 µM 0.362964913561202 0.337593152054591 no 1140 0.35831554721927 1682 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2233 sulbentine 40.3845 µM 0.362258644316748 0.337871202483524 no 1141 0.358579379691942 1671 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2583 asiatic acid 100 µM 0.361714034751434 0.338085669714379 no 1142 0.358782869016649 1705 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1886 st057356 49.9 µM 0.361506942105627 0.338167236588919 no 1143 0.3588602581713 1627 24207747 SGTC_3219 9131112 49.47 µM 0.36026878955011 0.338655061883395 no 1144 0.359323068382223 1695 17612988 YMR079W SEC14 SGTC_2002 4023503 131 µM 0.359914041637018 0.338794880555527 no 1145 0.359455708022812 1871 4736863 YCR052W RSC6 SGTC_1682 st012968 530 nM 0.358903044169111 0.339193472153913 no 1146 0.35983381111679 1623 24207270 SGTC_2638 epoxomicin 18 µM 0.358059227379928 0.339526289666135 no 1147 0.360149495357322 1788 9915668 A protesome inhibitor. SGTC_3146 9095609 49.47 µM 0.357650663251514 0.339687480185708 no 1148 0.360302379480083 1752 17173999 SGTC_1778 st046819 58.9 µM 0.356557456168804 0.340118926544987 no 1149 0.360711565840631 1676 671715 SGTC_811 0416-0114 265 µM 0.354818251811205 0.340805754398896 no 1150 0.361362876970335 1685 6612453 SGTC_3089 9117425 49.47 µM 0.352680947386481 0.341650518719668 no 1151 0.362163822234285 1637 9401657 SGTC_941 3237-0776 460 µM 0.352500659495606 0.341721813422942 no 1152 0.362231411980968 1803 760008 SGTC_484 loperamide 105 µM 0.351932489774668 0.341946532612604 no 1153 0.362444446321494 1710 3955 An opioid-receptor agonist. SGTC_1170 0310-0127 64.8 µM 0.349502538452098 0.342908243959512 no 1154 0.363356032711932 1759 774975 SGTC_1861 st057647 17.4 µM 0.348972319233842 0.343118226506247 no 1155 0.363555045404819 1836 688668 SGTC_2216 7189485 200 µM 0.348222075286069 0.343415428150542 no 1156 0.363836705176898 1779 731273 SGTC_994 3910-0338 138 µM 0.348100821812651 0.343463470598269 no 1157 0.36388223358319 1781 3479481 SGTC_1961 st076550 68.7 µM 0.344764885927041 0.344786208087029 no 1158 0.365135566658682 1725 1579337 SGTC_2355 9061122 103.12 µM 0.343889470727032 0.345133635729136 no 1159 0.365464705319652 1822 5302957 SGTC_2279 7948423 32.93 µM 0.343785131411166 0.345175053780067 no 1160 0.365503941436171 1875 1247112 SGTC_370 0180-0345 38.7 µM 0.34368990095733 0.345212857638183 no 1161 0.365539753453273 1672 3989527 SGTC_1058 3448-5425 97.3 µM 0.343227779568105 0.345396328984937 no 1162 0.365713553776966 1754 7279705 SGTC_708 3448-5400 146 µM 0.343198288479193 0.345408038765245 no 1163 0.365724646086355 1749 3462195 SGTC_381 3461-2219 42.7 µM 0.34177355337875 0.34597392248417 no 1164 0.366260656864913 1823 2883159 SGTC_1955 wogonin 32.4 µM 0.341401814695361 0.346121628261239 no 1165 0.366400554577639 1813 5281703 A flavanone. SGTC_1507 4075-3230 155 µM 0.34105318044281 0.346260175054062 no 1166 0.366531773454607 1803 659771 SGTC_3010 9080089 71.4286 µM 0.340533958688602 0.346466551233032 no 1167 0.366727226933665 1801 17027233 SGTC_2335 9018011 154.17 µM 0.340206263193173 0.346596824528586 no 1168 0.366850600930441 1811 6458208 SGTC_23 0213-0011 39.996 µM 0.339997062819127 0.346680000319196 no 1169 0.366929369922274 1828 627608 SGTC_3322 9139058 2.11 µM 0.339104142052715 0.34703509894773 no 1170 0.367265639105951 1771 4908926 YPR165W RHO1 SGTC_1488 4013-0813 75.9 µM 0.33866548717558 0.347209593389553 no 1171 0.367430871502674 1716 2910057 SGTC_3006 9075424 71.4286 µM 0.33829442753436 0.347357224120719 no 1172 0.367570661311464 1661 7465181 SGTC_2595 hexamethylquercetagetin 100 µM 0.335893213222926 0.348313136362771 no 1173 0.368475697548172 1735 386331 SGTC_3055 9094636 49.47 µM 0.333961325970816 0.34908291209184 no 1174 0.369204371112177 1789 25236176 SGTC_2274 7947094 46.08 µM 0.333538100645303 0.34925163265183 no 1175 0.369364067070384 1669 2971028 SGTC_3042 9091578 49.47 µM 0.332571345194992 0.34963714551008 no 1176 0.369728938219882 1756 25236497 SGTC_3044 9093193 49.47 µM 0.331581681167843 0.350031954292293 no 1177 0.370102577015714 1671 25236277 SGTC_1931 st074438 57.1 µM 0.329804240083987 0.350741439602135 no 1178 0.370773941676512 1699 2787313 SGTC_2297 7971671 152.32 µM 0.329042743225261 0.351045559033752 no 1179 0.371061690389248 1827 909016 SGTC_669 0108-0021 26.2 µM 0.328902529682582 0.351101566604989 no 1180 0.371114681094929 1974 17201 SGTC_160 3453-0671 289.699 µM 0.328827919849671 0.351131370433728 no 1181 0.371142879279685 1671 5322268 SGTC_2108 5365811 200 µM 0.328744771463096 0.351164586173139 no 1182 0.371174305357053 1795 780283 SGTC_1500 4488-1866 171 µM 0.328141848805614 0.351405472975617 no 1183 0.371402206710478 1831 2900003 SGTC_3072 9116419 49.47 µM 0.327858495444028 0.351518702293329 no 1184 0.371509328258614 1689 17170162 SGTC_1022 4477-0945 21.3 µM 0.327581974388541 0.351629214093544 no 1185 0.37161387645305 1699 4648966 SGTC_2546 rhodinyl acetate 100 µM 0.327095317152673 0.351823737390672 no 1186 0.371797896777591 1867 6708682 SGTC_654 1124-0271 80.9 µM 0.326722916006597 0.351972617230992 no 1187 0.37193873308834 1678 5403748 SGTC_680 0417-1641 114 µM 0.326316395056335 0.35213516351747 no 1188 0.372092492540728 1712 2835990 SGTC_3345 9148410 3.559 µM 0.325383032786155 0.352508468052611 no 1189 0.372445597669247 1835 4903596 SGTC_1568 digitonin 820 nM 0.324931597095325 0.352689073811677 no 1190 0.372616421150113 1908 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.324609706795731 0.352817872663177 no 1191 0.372738239899314 1719 442882 SGTC_590 k048-0076 22.4 µM 0.324602771516086 0.352820647881414 no 1192 0.372740864682346 1838 6832814 SGTC_215 1287-0124 461.5 µM 0.32438308011863 0.352908563540042 no 1193 0.372824013955009 1863 5560863 SGTC_2311 7694451 200 µM 0.323689158401695 0.353186307291563 no 1194 0.373086689841094 1795 2163142 SGTC_325 2810-4341 181 µM 0.323266635699517 0.353355461293063 no 1195 0.373246659739651 1862 774970 SGTC_2391 6285546 200 µM 0.32286737256596 0.353515330113588 no 1196 0.373397843491763 1704 846083 SGTC_1413 3910-0535 34.4 µM 0.322606558195217 0.353619776667617 no 1197 0.373496613186169 1813 2876951 SGTC_2443 5493264 126.67 µM 0.322132726227208 0.353809557122484 no 1198 0.373676073326939 1848 5340055 SGTC_2044 5102272 200 µM 0.321746928411488 0.353964104739222 no 1199 0.373822211457445 1738 592666 SGTC_1053 3366-3204 134 µM 0.320938711524421 0.354287948149023 no 1200 0.374128418439583 1681 3632071 YPR165W RHO1 SGTC_251 melphalan 456.522 µM 0.320796489917244 0.354344945657742 no 1201 0.374182309785801 1848 460612 A DNA alkylator. SGTC_288 1315-0019 35.1 µM 0.319703535153086 0.354783072974187 no 1202 0.374596539832278 1772 6811474 SGTC_3034 9090421 49.47 µM 0.318684257983693 0.355191838695316 no 1203 0.374982976523233 1872 17173761 SGTC_2182 6325192 200 µM 0.317942258402323 0.355489511295202 no 1204 0.375264368451475 1808 736248 SGTC_2325 6158266 200 µM 0.317896609899361 0.355507827270702 no 1205 0.375281682113394 1735 3623240 SGTC_2179 6298986 200 µM 0.317470438070192 0.355678840271703 no 1206 0.375443333594909 1891 738374 SGTC_2662 daunorubicin 22.37 µM 0.317411171073083 0.355702625063014 no 1207 0.375465815926641 1754 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2080 5212524 12.4 µM 0.315727115617095 0.356378697842647 no 1208 0.376104821690576 1902 260183 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.31358041091694 0.35724115815433 no 1209 0.37691986972232 1708 688669 SGTC_195 4234-0266 16.654 µM 0.313426087652777 0.357303187256899 no 1210 0.376978483444879 1762 2303354 SGTC_926 2268-1401 59.4 µM 0.312125560589872 0.357826074202902 no 1211 0.377472550842061 1727 2931578 SGTC_1590 st077108 57.8 µM 0.311389954228625 0.358121948659604 no 1212 0.377752094963105 1887 5489485 SGTC_3039 9090270 49.47 µM 0.310648843345924 0.358420123327354 no 1213 0.378033795664934 1900 17173750 SGTC_2888 9058547 12.99 µM 0.310109453058612 0.358637193089719 no 1214 0.378238861946604 1702 16476514 SGTC_3205 9113483 49.47 µM 0.308946864649622 0.359105215093565 no 1215 0.378680973290944 1870 17018033 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.30800232092958 0.359485614863281 no 1216 0.379040283145528 1899 756377 SGTC_1098 clofazimine 15.1 µM 0.307513855653667 0.359682391052992 no 1217 0.379226139172085 1838 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_61 0978-8327 98.565 µM 0.307431200015489 0.359715692212424 no 1218 0.379257591557506 1835 6150059 YHR072W ERG7 SGTC_367 0335-0881 7.1 µM 0.307244721783942 0.359790826405251 no 1219 0.379328553780556 1847 23828853 SGTC_2306 7482397 179.52 µM 0.307022569804552 0.359880341028028 no 1220 0.379413096559524 1869 891448 SGTC_2223 6903751 107.57 µM 0.305642985044353 0.360436407179702 no 1221 0.379938244148077 1836 5598863 SGTC_2399 5884133 200 µM 0.305072092557691 0.36066660199658 no 1222 0.380155622793688 1714 722445 SGTC_271 rotenone 740 µM 0.303769256927843 0.361192119345856 no 1223 0.380651845013753 1852 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2373 9071805 200 µM 0.301943195603624 0.361929128157073 no 1224 0.381347683127584 1938 10149009 SGTC_2188 6126565 140.678 µM 0.300656929130749 0.362448580396545 no 1225 0.381838057749878 1866 874518 SGTC_2748 diazoxide 86.69 µM 0.298183301437024 0.363448253846114 no 1226 0.382781632969849 1845 3019 A potassium channel activatior. SGTC_2946 9065502 71.43 µM 0.296129712008812 0.364278883545885 no 1227 0.383565512065293 1790 16489101 SGTC_1824 st053723 68.6 µM 0.294296224591017 0.365021026191711 no 1228 0.384265778662505 1729 675225 SGTC_2898 9056270 58.44 µM 0.293354399914296 0.365402446432443 no 1229 0.384625638248006 1805 19154699 SGTC_2829 7992743 58.44 µM 0.29115380398784 0.366294162421604 no 1230 0.385466845891773 1985 16462845 SGTC_3185 9108267 49.47 µM 0.288769776621872 0.367261022978792 no 1231 0.386378781002573 1735 4910486 SGTC_161 4065-0411 162.148 µM 0.288703002652993 0.367288115827352 no 1232 0.386404332359717 1816 1906281 YLR208W SEC13 SGTC_3222 9128301 49.47 µM 0.288516432846016 0.367363818102316 no 1233 0.386475726739382 1767 4911358 SGTC_2773 thioridazine 9.09 µM 0.288105745909355 0.36753047595641 no 1234 0.386632897212322 1865 5452 An antipsychotic. SGTC_672 1441-0018 53.7 µM 0.287708396934424 0.367691744979944 no 1235 0.386784980930163 1754 251141 SGTC_2853 9015042 58.44 µM 0.287672199079354 0.367706437489571 no 1236 0.38679883637768 1728 6457456 SGTC_1450 4112-4260 37.6 µM 0.287418888383933 0.367809260319895 no 1237 0.386895800110964 1908 1633175 SGTC_493 zm226600 134 µM 0.286650102040936 0.368121380876798 no 1238 0.387190123797677 1840 5240098 A potassium channel opener. YCR052W RSC6 SGTC_612 0302-0167 22.4 µM 0.285059298701853 0.368767509472225 no 1239 0.387799355907269 1894 235821 SGTC_1709 st033179 39.1045 µM 0.281358067308954 0.370272253515787 no 1240 0.389217888477286 1796 573381 SGTC_2882 9058044 58.44 µM 0.280327236357245 0.370691695026226 no 1241 0.38961322827152 1715 18076804 SGTC_2060 5238662 140 µM 0.279731522471032 0.370934159047995 no 1242 0.389841745983534 1784 790130 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.279408733722278 0.371065560074399 no 1243 0.389965584671495 1816 5379071 SGTC_2721 ifenprodil 61.44 µM 0.279156258931314 0.371168348134406 no 1244 0.390062455024151 1900 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1768 st044301 37.178 µM 0.27907530657789 0.37120130757052 no 1245 0.390093516533424 1787 3931349 SGTC_1784 st039334 36.3 µM 0.278941198678903 0.371255911159122 no 1246 0.390144975429567 1918 3496984 SGTC_142 0335-0849 62.6745 µM 0.27771293703081 0.371756132587538 no 1247 0.390616364396317 1827 3889043 YPR107C YTH1 SGTC_2766 oltipraz 83.91 µM 0.277674024242557 0.371771983740691 no 1248 0.390631301190476 1908 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_968 1309-0633 340 µM 0.277378313930294 0.37189244865676 no 1249 0.390744815780655 1929 3761976 SGTC_366 0181-0206 4.31 µM 0.276598511827074 0.3722101804687 no 1250 0.391044203761379 1973 274874 SGTC_3073 9114972 49.47 µM 0.274597478939937 0.373025902713289 no 1251 0.391812751711065 1956 41905075 SGTC_1750 st081859 2.357 µM 0.274115695963189 0.373222387043145 no 1252 0.391997856010374 1848 5291695 SGTC_79 0052-0007 94.094 µM 0.273597730472493 0.373433664375769 no 1253 0.392196889146991 1925 2801472 SGTC_2241 6772625 37.8075 µM 0.273386185863218 0.373519964046653 no 1254 0.392278185278645 1815 2285411 SGTC_2496 diffractaic acid 79.83 µM 0.272973807181839 0.373688212254098 no 1255 0.392436675019025 1944 94870 An apoptosis inducer which activates caspases. SGTC_3299 9121982 43.1275 µM 0.271393497267939 0.374333192557184 no 1256 0.39304420143357 1799 17594604 YPL160W CDC60 SGTC_3085 9117376 49.47 µM 0.269876264276542 0.374952760058807 no 1257 0.393627724109599 1854 16480349 SGTC_1481 3346-2004 36 µM 0.269808830794466 0.374980304266506 no 1258 0.393653664354701 1853 2770522 SGTC_840 0245-0196 390 µM 0.269670335276979 0.375036876817948 no 1259 0.393706942153157 1905 3827528 SGTC_2771 fluoxetine 41.05 µM 0.269137877642104 0.375254399765582 no 1260 0.393911791641249 1911 3386 A selective serotonin reuptake inhibitor. SGTC_3218 9131285 49.47 µM 0.2657125165651 0.376654695658578 no 1261 0.395230311495563 1952 17156417 SGTC_2865 9030313 51.95 µM 0.265680717779909 0.376667702717208 no 1262 0.395242557408066 1758 42562754 SGTC_2439 5492030 7.2 µM 0.264874006945943 0.376997728630135 no 1263 0.395553261406034 1952 5722370 SGTC_3266 9136860 49.47 µM 0.263968810324047 0.377368152147036 no 1264 0.395901976164221 1823 4871271 YPR165W RHO1 SGTC_739 1486-1183 203 µM 0.263152507179152 0.377702295562357 no 1265 0.396216517379463 1975 4346692 SGTC_2172 5754775 163.918 µM 0.263001930519873 0.377763942229788 no 1266 0.396274545572128 1783 2263357 SGTC_503 tyrphostin 8 294 µM 0.262734701691926 0.377873354411651 no 1267 0.396377534029034 1951 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_744 1594-0068 283 µM 0.26194202212036 0.378197960839538 no 1268 0.396683070698735 1817 668392 SGTC_22 0964-0034 14.468 µM 0.259387661541291 0.379244568828458 no 1269 0.397668074344295 1840 138402 SGTC_2907 7721985 69.9 µM 0.258946362514611 0.379425473916226 no 1270 0.397838312845119 1802 3267881 SGTC_1234 0326-0494 15.5 µM 0.255661018893913 0.380773087409683 no 1271 0.399106298701443 1939 1547813 SGTC_59 0330-0160 1.33 µM 0.253567472617338 0.381632594463014 no 1272 0.399914864273471 1900 4293482 SGTC_1140 3229-1848 2.98 µM 0.253360435838976 0.38171762537225 no 1273 0.399994849018376 1972 2849525 SGTC_1847 st056231 15 µM 0.253074704313124 0.381834985931684 no 1274 0.400105242881413 1818 5393180 SGTC_3230 9131665 49.47 µM 0.252934353314287 0.381892637282801 no 1275 0.400159471144937 1881 15943720 SGTC_128 0906-2981 13.371 µM 0.25290519097297 0.381904616495834 no 1276 0.400170739016564 1974 6740226 SGTC_2113 5491891 107.031 µM 0.252647486319227 0.382010480500501 no 1277 0.400270315666804 1788 789979 SGTC_2119 5528445 120.635 µM 0.252568677790341 0.382042856479799 no 1278 0.400300768446299 1963 791935 SGTC_964 1287-0107 19.4 µM 0.25193633409814 0.382302664633215 no 1279 0.400545137317495 1955 51516812 YPR165W RHO1 SGTC_1797 st048695 56.8 µM 0.251425691237964 0.382512508808735 no 1280 0.400742503388465 1969 592262 YIL048W NEO1 SGTC_2600 tangeritin 87.95 µM 0.249657910226626 0.383239228921256 no 1281 0.401425955179355 1806 68077 A bioactive flavone. SGTC_2298 7976326 193.81 µM 0.248909571296657 0.383546988838931 no 1282 0.401715365722184 1926 2235818 SGTC_74 000s-0487 160.283 µM 0.248816423236496 0.383585301814044 no 1283 0.401751393323312 2016 677548 SGTC_3101 9120531 49.47 µM 0.24852631588457 0.383704633928046 no 1284 0.401863605753396 1971 24824904 SGTC_1392 3455-1037 33.9 µM 0.247299618380489 0.384209342758183 no 1285 0.402338177053155 1938 981132 SGTC_2709 st078560 56 µM 0.247108048737074 0.384288179363582 no 1286 0.40241230243535 1972 17250903 SGTC_1466 k213-0079 57.5 µM 0.244565746730571 0.385334864363182 no 1287 0.403396344431313 1872 3657981 SGTC_352 k048-0007 5.11 µM 0.244544795409877 0.385343493663303 no 1288 0.403404456553515 1941 6811911 SGTC_1145 3546-0597 10.2 µM 0.242111217341305 0.386346205904319 no 1289 0.404346993279227 1883 875334 SGTC_491 tetrandrine 80.3 µM 0.240006039237065 0.38721421979118 no 1290 0.405162787395271 1965 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3153 9100258 49.47 µM 0.239053570475278 0.387607130472708 no 1291 0.405532021723336 1821 25236848 SGTC_1539 benzyladenosine 56 µM 0.238316130432591 0.387911416998287 no 1292 0.405817955720022 1883 92208 A nucleotide analog. SGTC_2372 9071633 200 µM 0.238254733805736 0.387936753915532 no 1293 0.405841763832654 2023 21321366 SGTC_2099 5377090 177.372 µM 0.23726881159312 0.388343685669199 no 1294 0.406224128032798 1865 2243829 SGTC_2738 aclarubicin 5.55 µM 0.23723188496984 0.388358929231418 no 1295 0.406238450800124 1959 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3265 9137266 49.47 µM 0.237179047382919 0.388380741247131 no 1296 0.406258945187478 2054 17224265 SGTC_2523 spermine 47.74 µM 0.236999382365439 0.388454911843136 no 1297 0.406328634705589 2009 1103 A DNA binding polyamine. SGTC_2363 9053361 176 µM 0.236925556699643 0.388485390261112 no 1298 0.406357271497077 1980 6469797 YMR079W SEC14 SGTC_2479 5617353 43.85 µM 0.236568518283408 0.388632800800405 no 1299 0.406495772873879 1951 2731746 SGTC_2737 bleomycin 30.5 nM 0.236072831320771 0.388837481786187 no 1300 0.406688077811751 1920 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1985 st071382 65.5 µM 0.23571475992093 0.388985357220994 no 1301 0.406827007911586 1873 6123237 SGTC_1346 1488-2224 62.4 µM 0.232240161345319 0.390421120497644 no 1302 0.408175743051412 2001 3722427 SGTC_3329 9141233 27.5565 µM 0.232035426432556 0.390505767299484 no 1303 0.408255249133369 1981 4909101 YNL103W MET4 SGTC_2094 5332512 191.667 µM 0.231283388875875 0.390816738629093 no 1304 0.408547325316396 1975 755774 SGTC_3305 9127027 53.8275 µM 0.230871493302154 0.390987089142525 no 1305 0.408707318773867 1896 41905295 SGTC_1226 3909-7979 35.4 µM 0.230522097671397 0.391131607520322 no 1306 0.408843047176413 1992 6615510 SGTC_1164 k060-0068 93.7 µM 0.229610662940452 0.391508669404082 no 1307 0.409197160204195 1947 5963676 SGTC_2022 5136654 200 µM 0.228420717144516 0.392001105133147 no 1308 0.409659592589894 1905 1713771 SGTC_1396 3511-0007 98.6 µM 0.228228814185766 0.392080536632889 no 1309 0.409734181003915 1897 X1396 SGTC_1007 4101-0031 70 µM 0.228030112635089 0.392162786910753 no 1310 0.409811415321985 2015 1146276 SGTC_3063 1327-0034 4 µM 0.227291716208951 0.392468480023505 no 1311 0.410098457033774 1972 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_861 0443-0273 110 µM 0.225245391006247 0.393315996556737 no 1312 0.41089418983414 1952 6149169 SGTC_2008 4012253 172 µM 0.224949725413969 0.393438492848135 no 1313 0.411009192587212 1873 603940 SGTC_1923 st058458 19.1 µM 0.224660121025906 0.393558488167569 no 1314 0.411121845176209 2021 3534982 SGTC_2267 7931562 200 µM 0.224375263848239 0.393676526380115 no 1315 0.411232658308541 1759 934880 SGTC_360 0957-0399 1.01 µM 0.223949942319998 0.393852787946793 no 1316 0.411398127073106 1985 6752301 YPR165W RHO1 SGTC_1388 3346-4487 254 µM 0.223446020915 0.394061650986708 no 1317 0.411594195041512 1969 3345614 SGTC_32 0928-0142 34.1 µM 0.223268270929505 0.394135331260938 no 1318 0.411663360061638 1998 2244242 SGTC_1189 1431-2119 7.28 µM 0.223101408438054 0.394204501938868 no 1319 0.411728291102577 1945 3107275 SGTC_1665 st014639 11.4 µM 0.222519734304641 0.394445653470973 no 1320 0.411954656288197 1959 981133 YIL048W NEO1 SGTC_1248 0469-0687 58.6 µM 0.222456510529741 0.39447186733937 no 1321 0.411979262314876 1949 4017482 SGTC_1139 k015-0024 46.9 µM 0.22084829093646 0.395138828409601 no 1322 0.412605280533775 2040 2766652 SGTC_849 0386-0493 241 µM 0.219067537628929 0.395877701202363 no 1323 0.413298718897897 1928 726119 SGTC_358 0075-0058 9.45 µM 0.214634686018505 0.397718606752316 no 1324 0.415026074292996 2149 1069125 SGTC_893 0958-0369 48.9 µM 0.212310959602515 0.398684533586142 no 1325 0.415932222900821 2066 6819948 SGTC_2308 7584454 197.62 µM 0.211920033826364 0.398847094830324 no 1326 0.416084710409119 2019 893577 SGTC_795 0685-0265 78 µM 0.211793153644644 0.398899860026649 no 1327 0.416134204983153 1995 302754 SGTC_1701 st028638 40.4 µM 0.210664817273574 0.399369178309238 no 1328 0.416574415105132 2003 3490878 SGTC_3251 9135047 49.47 µM 0.210470648713223 0.399449955133897 no 1329 0.416650178762984 2030 17682963 SGTC_3320 9137005 35.139 µM 0.210335292957784 0.399506267559305 no 1330 0.41670299577303 1892 4908713 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.210286593376471 0.399526528690898 no 1331 0.416721999147234 2005 804 An inhibitor of viral and cellular DNA polymerases. SGTC_913 3487-1245 167 µM 0.210166709667322 0.399576406650487 no 1332 0.416768780563054 1897 4016153 SGTC_646 4092-0839 27.3 µM 0.208227886685596 0.400383286533275 no 1333 0.417525517677091 2000 877796 SGTC_2406 ethylparaben 405.7 µM 0.207904520971621 0.400517903108483 no 1334 0.417651759540037 1672 8434 A possible steroid mimic. SGTC_27 0485-0001 32.618 µM 0.206552074628524 0.401081052027195 no 1335 0.418179845961696 2050 2054479 SGTC_1036 k216-0215 33.5 µM 0.206345948547763 0.401166899526321 no 1336 0.41826034448917 1879 622330 SGTC_2648 atorvastatin 78.68 µM 0.203181596269271 0.402485387169686 no 1337 0.419496548433758 2033 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2356 9061756 188.97 µM 0.203151926115687 0.402497755080386 no 1338 0.419508143326393 2052 20104043 SGTC_3097 9117246 49.47 µM 0.203128976497455 0.402507321623888 no 1339 0.419517111927817 2024 16423892 SGTC_1270 0831-1170 17.3 µM 0.20311727667213 0.402512198716068 no 1340 0.419521684179882 2000 6764716 SGTC_1964 st076914 61 µM 0.201396045240586 0.403229861907494 no 1341 0.420194453651268 2043 24208661 SGTC_170 4197-0004 226 µM 0.201265187347646 0.403284436149266 no 1342 0.42024561101294 1972 218692 SGTC_749 1000-0129 128 µM 0.201151135563273 0.403332002945287 no 1343 0.420290199322104 2050 708470 SGTC_3257 9139206 32.98 µM 0.200167644506706 0.403742240090791 no 1344 0.420674735500672 2039 4910041 SGTC_3180 9109287 49.47 µM 0.200044480874835 0.403793621996787 no 1345 0.420722896717146 1959 18891271 SGTC_2015 5119600 184 µM 0.199853392727501 0.403873344214886 no 1346 0.42079762110399 2030 2828786 SGTC_3108 9121785 49.47 µM 0.19830692144093 0.404518680657397 no 1347 0.421402468350992 2075 17140271 SGTC_1924 st058459 75.1 µM 0.19736814548344 0.404910555067079 no 1348 0.42176972776206 2002 688683 SGTC_3210 9128157 49.47 µM 0.196985929356799 0.405070131361619 no 1349 0.421919274398567 1805 17590849 SGTC_2834 9001755 58.44 µM 0.196708875976392 0.405185811787113 no 1350 0.422027681891588 1916 2989575 SGTC_2334 9017922 200 µM 0.195745678588154 0.405588048087438 no 1351 0.422404614804002 2037 3163164 SGTC_732 3970-1727 52.7 µM 0.193654966781261 0.406461482940781 no 1352 0.423223027762276 2085 1275699 SGTC_1200 1643-0193 18.4 µM 0.192262180326927 0.407043604816348 no 1353 0.423768420713532 2076 5403974 SGTC_255 tunicamycin 200.472 nM 0.191783794059558 0.407243596141721 no 1354 0.423955782894574 2087 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3043 9092303 49.47 µM 0.191359442865934 0.407421018126886 no 1355 0.424121996379573 1905 25236084 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.191296181800431 0.407447469318048 no 1356 0.424146776168585 1926 5282362 SGTC_2082 5219693 150 µM 0.191202184651241 0.40748677289038 no 1357 0.424183596044121 1985 2834649 SGTC_1619 st003326 88.7 µM 0.191023256180562 0.407561591861421 no 1358 0.424253686424001 2059 2849032 SGTC_447 ml7 120 µM 0.190833997706673 0.407640733994695 no 1359 0.424327825909829 2092 4216 Selective myosin light chain kinase inhibitor. SGTC_2560 caryophyllene 100 µM 0.190529397126919 0.407768116600095 no 1360 0.424447154750855 2048 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_514 4466-0038 2.65 nM 0.18998509567931 0.407995765312861 no 1361 0.424660404875315 1975 5722064 SGTC_2687 chenodiol 100 µM 0.189046316382463 0.408388473443428 no 1362 0.425028258000048 1978 5702181 A cholesterol synthesis inhibitor. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.188660917292149 0.40854971942528 no 1363 0.425179292458454 2049 94937 An inhibitor of serotonin biosynthesis. SGTC_2914 7968218 45.32 µM 0.187509402122405 0.409031590577805 no 1364 0.425630626300944 2042 2977111 SGTC_594 1487-1584 10.8 µM 0.18733884246419 0.409102975884279 no 1365 0.425697485085501 1912 5013332 SGTC_2880 9042983 58.44 µM 0.186895423137502 0.409288576805233 no 1366 0.425871313889863 1966 6464714 SGTC_3236 9132701 49.47 µM 0.185918207925806 0.409697679073873 no 1367 0.426254451639378 1947 24282524 SGTC_250 brefeldin a 552.239 µM 0.185231435829641 0.409985248837813 no 1368 0.426523756740017 1985 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1805 st050013 60.3 µM 0.18502009070759 0.410073754418316 no 1369 0.426606638758929 2045 4037144 SGTC_2313 7726885 200 µM 0.183278729140874 0.410803163190773 no 1370 0.427289661693353 1975 726423 SGTC_1081 sertraline 6 µM 0.182765877635727 0.411018041602545 no 1371 0.427490861648249 2097 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3059 1327-0034 3 µM 0.182450472987205 0.411150205498374 no 1372 0.427614609371445 1948 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_337 1315-0038 354 µM 0.182073368476826 0.411308236701318 no 1373 0.427762574129192 1977 1626437 SGTC_944 3370-0224 231 µM 0.181378316131723 0.411599546321559 no 1374 0.428035318903669 1949 4580514 SGTC_1627 st003713 25.6 µM 0.179023572715069 0.412586825278907 no 1375 0.428959596172392 1963 16195070 YER133W GLC7 SGTC_530 4358-1714 28 µM 0.17886585391816 0.412652972259358 no 1376 0.429021517492062 2032 1564641 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.17809244541873 0.412977374269239 no 1377 0.429325187438179 2114 551469 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.177349640208368 0.413288995852221 no 1378 0.429616880737052 2043 229346 A bile salt which induces apoptosis. SGTC_36 0335-0881 14.2 µM 0.176389762744376 0.413691764459791 no 1379 0.429993873359667 2004 23828853 SGTC_616 4092-0450 108 µM 0.174513874797484 0.414479156717092 no 1380 0.430730813783085 2023 787165 SGTC_263 alizarin 107.927 µM 0.172551915731323 0.415303044580368 no 1381 0.431501825256723 2058 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_985 1493-0307 8.71 µM 0.172034002589858 0.415520594779177 no 1382 0.431705398645298 2122 3278274 SGTC_1994 st072947 40.9 µM 0.171592879394325 0.415705909670695 no 1383 0.431878802920825 2016 5286565 YDL195W SEC31 SGTC_3031 9088762 49.47 µM 0.171150198910017 0.415891897623132 no 1384 0.432052832557789 2074 205253 SGTC_839 0122-0028 230 µM 0.170963291970633 0.415970430436948 no 1385 0.432126314677172 2026 759448 SGTC_976 1348-1067 47.6 µM 0.170529085025299 0.41615288440697 no 1386 0.432297031398388 2045 5310671 YGL099W LSG1 SGTC_3291 9121177 71.43 µM 0.170359075307522 0.41622432749836 no 1387 0.432363877398782 1967 17015612 SGTC_1971 st069429 63.5 µM 0.169158933334818 0.416728741118678 no 1388 0.432835815336051 2115 1246522 YGL099W LSG1 SGTC_3040 9091894 49.47 µM 0.168318334702635 0.417082122199311 no 1389 0.433166425315322 2079 25236966 SGTC_2107 5363541 170.161 µM 0.168184773087594 0.417138276631805 no 1390 0.433218959814481 2109 244052 SGTC_2225 6654152 15.4 µM 0.167568325344242 0.417397476826161 no 1391 0.433461445756857 2087 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_314 1671-0008 2.74 µM 0.164212471533341 0.418809152631617 no 1392 0.43478194175932 2056 3913060 SGTC_676 falcarinol 140 µM 0.163598988924801 0.419067334288164 no 1393 0.435023420351306 2124 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2369 9071472 200 µM 0.163465302169468 0.419123600443772 no 1394 0.435076045257075 2027 17296037 SGTC_3326 9140064 16.379 µM 0.163177426215397 0.419244767449253 no 1395 0.435189369623015 2050 1868434 SGTC_2040 5100729 123 µM 0.162779355002793 0.419412328260611 no 1396 0.435346081885038 2037 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2884 9058502 51.95 µM 0.162733566606066 0.419431602988282 no 1397 0.435364108465237 2018 6471554 SGTC_1423 4048-0112 5.59 µM 0.161746070644332 0.419847338583582 no 1398 0.435752911530026 2119 X1423 SGTC_2462 5162487 171.77 µM 0.161437154040947 0.419977410802503 no 1399 0.435874552870997 2136 2259986 SGTC_1385 3091-4834 14.1 µM 0.160858093091252 0.420221253359549 no 1400 0.436102584630224 2062 4072814 SGTC_1116 jasmonic acid  1.58368 µM 0.160657644097178 0.420305669567854 no 1401 0.43618152555142 2091 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2344 7990960 76.95 µM 0.160592861491854 0.420332952613533 no 1402 0.436207038812559 1996 140813 SGTC_2362 9071156 126 µM 0.160050001278049 0.420561591978405 no 1403 0.436420843265892 2097 653133 SGTC_832 4083-0019 164 µM 0.158985941486351 0.421009825469382 no 1404 0.436839975008814 2098 1990758 SGTC_2704 st078022 71.1 µM 0.158563241588251 0.421187915581862 no 1405 0.437006495644631 2142 54697681 SGTC_2739 tacrine 100.86 µM 0.158467810146095 0.421228124581382 no 1406 0.437044091957626 2051 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3337 9144342 33.5465 µM 0.157052596251532 0.42182450576144 no 1407 0.437601698284195 2084 17682949 SGTC_602 3130-1533 38.1 µM 0.1566649924307 0.421987876104912 no 1408 0.437754439159121 2125 720941 SGTC_3282 9108498 15.4605 µM 0.156466561604251 0.422071517506611 no 1409 0.437832637278778 2002 16459645 SGTC_223 busulfan 5 mM 0.156128284892816 0.422214114029721 no 1410 0.437965951812755 2091 2478 A DNA alkylator. SGTC_349 k015-0014 24 µM 0.1552697094202 0.422576082047777 no 1411 0.438304347179718 1980 2196908 SGTC_2269 7935389 174.42 µM 0.155041264215699 0.422672403602967 no 1412 0.438394393231728 1952 97605 SGTC_3278 9139605 49.47 µM 0.154124580686125 0.423058960167277 no 1413 0.438755753628877 2104 7958859 SGTC_902 1120-0002 2.07 µM 0.153721243689774 0.423229066963544 no 1414 0.438914766915194 2117 3280475 SGTC_469 w7 172 µM 0.152089268906326 0.423917495764806 no 1415 0.439558263959454 2153 45115570 A P450 inhibitor. SGTC_1938 st074717 56.4 µM 0.151719248714239 0.424073616676723 no 1416 0.439704187324456 2110 17250979 SGTC_1118 chelidonine 707.474 nM 0.151442244841133 0.424190499443201 no 1417 0.439813433583442 2166 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1526 st051518 75 µM 0.150996454935921 0.424378616070804 no 1418 0.439989256193488 1984 673993 SGTC_2235 salicylic acid 500 µM 0.150064068607409 0.42477212471263 no 1419 0.440357034009836 2152 338 A COX inhibitor and kinase inhibitor. SGTC_2178 5812956 200 µM 0.148613349852648 0.425384541726277 no 1420 0.440929369168533 2149 5403383 SGTC_991 3996-0057 64.7 µM 0.146706084314745 0.426189962513945 no 1421 0.441682007991683 2071 715343 SGTC_2421 5690543 90.72 µM 0.146030583219569 0.426475294471966 no 1422 0.441948622648304 2047 3397993 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.142625162412235 0.427914328801367 no 1423 0.443293111954974 2038 279621 SGTC_2954 9074818 52.69 µM 0.142608931253546 0.427921189941295 no 1424 0.443299521731625 2080 16648742 SGTC_948 3448-0295 75.3 µM 0.142405080873659 0.428007362229808 no 1425 0.443380024665912 2106 678569 SGTC_1872 amphotericin b 148 nM 0.140900781505793 0.428643370393232 no 1426 0.443974162377646 2133 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1636 st007707 68.9 µM 0.140472498004343 0.428824479891937 no 1427 0.444143340215538 2125 403051 SGTC_1706 st031321 9.9705 µM 0.140339102519539 0.428880892294148 no 1428 0.44419603533585 2145 6103185 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.13996977002035 0.429037089066309 no 1429 0.444341937625449 2143 165506 SGTC_2749 bexarotene 57.39 µM 0.139676792084972 0.429161002146595 no 1430 0.444457681930188 2012 82146 An retinoic acid receptor inhibitor. SGTC_3258 9138477 49.47 µM 0.138833408604045 0.429517744544641 no 1431 0.444790896688205 2167 4970355 SGTC_2821 7996764 71.43 µM 0.138486678908185 0.429664424296541 no 1432 0.444927898432789 2077 2987135 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.138244095289259 0.429767052100211 no 1433 0.445023753318962 2060 23665772 A membrane-active detergent. SGTC_2541 muurolladie-3-one 83.07 µM 0.138016095680507 0.429863514296588 no 1434 0.445113848386245 2111 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2163 5671233 125 µM 0.13784523106628 0.429935806533806 no 1435 0.445181368163066 2148 701023 SGTC_311 1315-0136 58 µM 0.137526018399077 0.430070870619559 no 1436 0.445307514210965 2130 6759207 SGTC_1102 cgs 12066b 26.1 µM 0.137230324089565 0.430195991006059 no 1437 0.445424371245992 2068 6438352 A 5-HT1B full agonist. SGTC_1936 st074407 74.3 µM 0.136633444215601 0.430448576696829 no 1438 0.445660269871259 1999 809813 SGTC_162 k030-0015 37.8 µM 0.136198174407373 0.430632790714139 no 1439 0.44583230916628 2141 1809920 YMR134W ERG29 SGTC_1776 st049249 45.9 µM 0.135978850639801 0.430725618202242 no 1440 0.44591900019921 2009 1822314 SGTC_3170 9103054 49.47 µM 0.135492906504536 0.430931304813301 no 1441 0.446111086165334 2053 16432970 SGTC_880 0833-0487 87.2 µM 0.135058473156759 0.431115204207168 no 1442 0.446282821447841 2126 76075 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.13257011027098 0.432168836326729 no 1443 0.447266686139106 2143 2333 A French combination drug. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.131878611797246 0.432461719265512 no 1444 0.447540153082736 2009 803109 SGTC_656 4090-1979 187 µM 0.131790364061739 0.432499099109465 no 1445 0.447575054217237 2182 22330961 SGTC_1702 st027038 51 µM 0.130692843168763 0.43296403574412 no 1446 0.448009147053584 2076 5521182 SGTC_825 1988-2224 89.6 µM 0.130170557717901 0.433185321239091 no 1447 0.448215743947139 2084 1180859 SGTC_818 4072-2707 53.5 µM 0.130035712342746 0.433242456861366 no 1448 0.448269086096101 2149 882871 SGTC_481 bay k-8644 50 µM 0.12694068066442 0.434554240555506 no 1449 0.449493674275433 2051 2303 A calcium channel antagonist. SGTC_2894 9048625 32.47 µM 0.126091656761239 0.43491421346475 no 1450 0.449829685849902 2184 4092861 SGTC_2531 methyl deoxycholate 70.07 µM 0.125861399825056 0.435011848131922 no 1451 0.44992081905432 2085 16667744 Haematoxylin. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.122256404218703 0.436540968887161 no 1452 0.451347978661095 2088 4213774 SGTC_946 3434-1334 87.4 µM 0.121609368870058 0.436815521123254 no 1453 0.451604196640161 2143 4047976 SGTC_2924 9010168 62.78 µM 0.121469160927625 0.436875018650333 no 1454 0.451659719909111 2086 2993929 SGTC_1360 1598-0022 39.8 µM 0.121343307261843 0.436928426126901 no 1455 0.451709559595328 2146 761525 SGTC_394 menadione 8.33 µM 0.120095566806424 0.437457981436982 no 1456 0.452203722075588 2198 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.118730593576684 0.438037419986866 no 1457 0.452744398905758 2048 2374 Ca(2+)-ATPase inhibitor. SGTC_1873 rapamycin 2 nM 0.117670048575487 0.43848771889427 no 1458 0.453164549821395 2098 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2580 diallyl disulphide 81.36 µM 0.117495733059364 0.438561739501767 no 1459 0.453233612575127 2098 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_508 roscovitine 141 µM 0.116908356458109 0.438811176437638 no 1460 0.453466338035342 2183 160355 A CDKinase inhibitor. SGTC_133 0724-0033 378.92 µM 0.116508445677616 0.438981017543676 no 1461 0.453624796500302 2214 280309 SGTC_565 1418-0001 44.5 µM 0.115705846247938 0.43932191337961 no 1462 0.453942836370494 2193 2862145 SGTC_87 0100-0052 35.5 µM 0.115228535828574 0.439524667417771 no 1463 0.454131990498514 2183 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1467 k284-1082 293 µM 0.11262772654278 0.440629728100902 no 1464 0.455162851152199 2231 3334705 SGTC_1237 0330-0133 46.1 µM 0.112144760857786 0.440834987091866 no 1465 0.45535431360661 2145 X1237 YHR072W ERG7 SGTC_1173 0443-0020 122 µM 0.111121920339403 0.441269743709052 no 1466 0.455759833235968 2101 5331295 SGTC_2870 9038528 12.99 µM 0.110541302863216 0.441516565703569 no 1467 0.455990047804618 2120 6463316 SGTC_610 4215-0184 155 µM 0.110035599355295 0.441731560085965 no 1468 0.456190571060583 2153 5605015 SGTC_1034 k072-0165 12.7 µM 0.110013135784521 0.441741110629072 no 1469 0.456199478650442 2202 5835461 SGTC_3245 9134821 49.47 µM 0.10777867474371 0.442691275605419 no 1470 0.457085629712539 2178 17014901 SGTC_1781 st038725 66.3 µM 0.107430543760037 0.442839341964419 no 1471 0.457223712150684 2029 4270275 YIL048W NEO1 SGTC_402 epigallocatechin gallate 10 µM 0.106976530821795 0.443032453812021 no 1472 0.457403799292523 2085 65064 An antioxidant. SGTC_247 mechlorethamine 29.705 µM 0.10689382920089 0.443067631939364 no 1473 0.457436604363349 2129 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1998 st075797 76.8 µM 0.105958875876249 0.443465356709997 no 1474 0.457807490369521 2230 24208315 SGTC_2329 6138490 200 µM 0.104407108012567 0.444125597032051 no 1475 0.458423141067437 2080 720019 SGTC_1427 4048-4900 550 nM 0.101920378121858 0.445183964132691 no 1476 0.459409937394283 2236 24132586 SGTC_2678 equilin 100 µM 0.100947323155065 0.445598208947039 no 1477 0.459796138250643 2240 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_252 miconazole 1.30953 nM 0.100481738152748 0.445796436848145 no 1478 0.459980940149415 2232 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2653 dihydrofissinolide 100 µM 0.0995418038618655 0.44619666538077 no 1479 0.460354049007831 2167 6857746 SGTC_1745 st081495 74 µM 0.0992679042046477 0.446313303502827 no 1480 0.460462780625851 2169 13842402 YBL026W LSM2 SGTC_2278 7948257 134.34 µM 0.0988800763364448 0.446478465045279 no 1481 0.460616744075661 2256 1247028 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0987457260468925 0.446535682030536 no 1482 0.460670081058988 2157 115019 SGTC_2250 alverine citrate 130 µM 0.098477606891502 0.446649871710905 no 1483 0.460776526314987 2175 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_182 3448-4371 550.524 µM 0.0983226038156987 0.446715888228346 no 1484 0.460838064946732 2255 3491403 SGTC_1925 st057770 10.1 µM 0.098196938454122 0.446769410763371 no 1485 0.460887956738132 1998 5989122 SGTC_2519 cryptotanshinone 88.04 µM 0.0978094349397261 0.446934459722055 no 1486 0.461041807655802 2210 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1806 st050005 60.3 µM 0.0963325137008735 0.447563607245797 no 1487 0.461628244480058 2111 5194765 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0950346548292716 0.448116585720694 no 1488 0.462143650452888 2180 688664 SGTC_131 0141-0277 33.849 µM 0.0946920651291076 0.448262569712621 no 1489 0.462279710383525 2217 1547771 SGTC_2390 9097792 176.6 µM 0.0932428390532736 0.448880189805407 no 1490 0.462855320983951 2072 4497149 SGTC_2471 5466956 24.79 µM 0.0924331648901638 0.449225304595812 no 1491 0.463176945218735 2151 724419 SGTC_1017 4239-0030 168 µM 0.0920951103693288 0.449369408035178 no 1492 0.463311236651973 2055 1149593 SGTC_1522 st012842 45.6 µM 0.091609520495185 0.449576413460218 no 1493 0.463504143500139 2204 3491067 YOR116C RPO31 SGTC_2445 5742597 35.57 µM 0.0904878411501516 0.450054634180337 no 1494 0.463949777835632 2149 1774255 SGTC_387 norethindrone acetate 66.7 µM 0.0902465575308097 0.450157513391273 no 1495 0.464045643840548 2146 541197 SGTC_2415 st077333 57.7 µM 0.0897504925354988 0.450369037540725 no 1496 0.464242745285747 2275 2766255 SGTC_2626 ethyl orsellinate 100 µM 0.0893769616437735 0.450528321953966 no 1497 0.464391166064628 2204 75653 A natural product. SGTC_39 0986-0283 58.349 µM 0.088934501281961 0.450717010201707 no 1498 0.464566982060314 2234 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2043 5101342 149 µM 0.0882299175609804 0.451017504538287 no 1499 0.464846969628846 2171 678451 SGTC_357 1325-0123 420 µM 0.088204011499962 0.451028553618971 no 1500 0.464857264515265 2242 1098503 SGTC_1243 0416-0003 5.65 µM 0.0879747103722334 0.451126353492593 no 1501 0.464948388195286 2159 2141977 SGTC_1951 sophoraflavanone G 9.2 µM 0.0879534177230227 0.451135435231368 no 1502 0.464956849932815 2185 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1871 st057448 67.3 µM 0.0863603072310544 0.451815000794237 no 1503 0.465589999622605 2232 691747 SGTC_562 3772-2733 112 µM 0.0863038799419998 0.4518390733156 no 1504 0.465612427119397 2238 2876874 YIL048W NEO1 SGTC_679 0422-0091 41.4 µM 0.0861604667467102 0.451900255807665 no 1505 0.465669428381707 2219 627384 YHR062C RPP1 SGTC_1030 k029-0042 36.7 µM 0.0854730824374771 0.45219352140191 no 1506 0.465942647123339 2117 6080581 SGTC_464 bw-b 70c 158 µM 0.0852963629914912 0.452268921195757 no 1507 0.466012891454813 2241 5353454 SGTC_1408 3909-7976 48.8 µM 0.0848304556781335 0.452467715234587 no 1508 0.466198090336165 2187 24152374 SGTC_2958 9077254 16.72 µM 0.0838741575180392 0.452875787259011 no 1509 0.466578243228678 2158 16457351 SGTC_3294 9122953 26.2835 µM 0.0833548346104011 0.453097413869279 no 1510 0.466784700118802 2257 16459826 SGTC_1154 4088-0362 150 µM 0.0831604474991478 0.453180374411587 no 1511 0.466861981042119 2245 6618304 SGTC_3116 9124943 49.47 µM 0.0822768698986583 0.453557493410727 no 1512 0.467213273597417 2184 41905195 YPL160W CDC60 SGTC_151 3013-0144 2.285 µM 0.0811360678284056 0.454044460064753 no 1513 0.467666871125932 2269 906558 YHR107C CDC12 SGTC_2969 9091408 28.7 µM 0.0796267707456408 0.454688829808782 no 1514 0.468267051419605 2045 4286311 SGTC_3027 9089541 49.47 µM 0.0768479163208191 0.455875527015481 no 1515 0.469372265850691 2197 9943819 SGTC_570 0987-0065 62.6 µM 0.0764440456430324 0.456048031183066 no 1516 0.469532914371675 2283 3104428 SGTC_1761 st044296 37 µM 0.0749584329858815 0.45668264785986 no 1517 0.470123892238568 2277 1826700 SGTC_3008 9078912 71.4286 µM 0.0742358588348292 0.45699135355929 no 1518 0.470411356666602 2232 16648731 SGTC_898 1000-0849 28.3 µM 0.0737302385983757 0.457207385381271 no 1519 0.470612518671335 2266 6751807 SGTC_212 3807-4682 38.772 µM 0.0734223713985603 0.457338931235828 no 1520 0.470735007918404 2240 3125501 YBL034C STU1 SGTC_1238 0333-0287 48.8 µM 0.0729932310101155 0.45752230263472 no 1521 0.470905752007281 2241 7226 SGTC_1732 st034308 51.822 µM 0.0727328203460127 0.457633580347298 no 1522 0.471009365422918 2198 830119 SGTC_1832 st054113 55 µM 0.0716307440087483 0.458104552160086 no 1523 0.471447886365598 2293 1251267 SGTC_2827 7993847 71.43 µM 0.0715109012136456 0.458155770481347 no 1524 0.471495574428741 2219 2985692 SGTC_9 0092-0002 10.449 µM 0.0704062988863477 0.4586278871784 no 1525 0.471935138952958 2282 759368 SGTC_2982 9019404 25.97 µM 0.0702387377484236 0.458699509389259 no 1526 0.472001821091197 2184 22333232 SGTC_2438 5259590 200 µM 0.0683410405229581 0.459510752734428 no 1527 0.472757077432557 2261 1201127 SGTC_1082 camptothecin 424.86 nM 0.0682337717443414 0.459556613947883 no 1528 0.47279977182196 2295 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1437 4092-1038 11.6 µM 0.0679550266654517 0.459675789885872 no 1529 0.47291071750154 2272 3977136 SGTC_2472 5377652 49.4 µM 0.0676628870226495 0.459800696485059 no 1530 0.47302699671979 2144 1610903 SGTC_955 1216-0110 33 µM 0.0675272239381783 0.459858701652316 no 1531 0.473080994957569 2248 3619719 SGTC_1684 st024538 14.6195 µM 0.0672735745408882 0.459967156259504 no 1532 0.473181956840115 2252 6732859 SGTC_3330 9141424 71.43 µM 0.0668454774218433 0.460150207423852 no 1533 0.473352359300417 2270 27261020 SGTC_1075 aripiprazole 15.2 µM 0.0666978703391853 0.460213325081709 no 1534 0.473411114880824 2260 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3338 9144300 39.5675 µM 0.0661125505513254 0.460463621124952 no 1535 0.473644109409308 2227 4901274 SGTC_974 1326-0144 138 µM 0.0654772907009087 0.460735290398944 no 1536 0.473896993461691 2221 5411856 SGTC_126 0417-1624 672.48 µM 0.0650183350505541 0.460931574482031 no 1537 0.474079700941436 2291 41912 YDL195W SEC31 SGTC_2646 retinol 96.75 µM 0.0644109780086606 0.461191340828429 no 1538 0.474321494496454 2257 445354 A vitamin A analog and teratogen. SGTC_2976 9009005 19.48 µM 0.0640140432392235 0.461361118613687 no 1539 0.474479522427388 2290 2993148 SGTC_1090 efavirenz 20.7 µM 0.063386870186307 0.461629388749963 no 1540 0.474729221149703 2230 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_167 3672-0051 66.205 µM 0.0628616914189516 0.461854044777346 no 1541 0.474938320151332 2290 3237971 SGTC_51 1013-0126 23.419 µM 0.0627138469125407 0.461917290506596 no 1542 0.474997185428969 2319 1627850 SGTC_2294 7971431 200 µM 0.0613323535756766 0.462508319587655 no 1543 0.475547262433317 2262 5741572 SGTC_1860 st056228 74.6 µM 0.06066064323862 0.462795720016358 no 1544 0.475814738037592 2185 688679 SGTC_2128 5255449 168.493 µM 0.0590954157866233 0.463465499031806 no 1545 0.476438054967404 2286 736008 SGTC_3082 9117008 49.47 µM 0.0582703646971642 0.463818589786517 no 1546 0.476766636468782 2192 41448529 SGTC_1079 idarubicin 2.36 µM 0.0573651269249925 0.464206030198064 no 1547 0.477127170959845 2310 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2388 9080168 200 µM 0.0559165005567456 0.464826110587972 no 1548 0.477704162925988 2315 15943073 SGTC_1136 pergolide 1.05886 µM 0.0555625841538032 0.464977616538758 no 1549 0.477845135977583 2201 47811 A dopamine receptor agonist. SGTC_1620 st003704 16.5 µM 0.0548833339591509 0.465268406886371 no 1550 0.47811570471945 2290 2834414 SGTC_453 enantio-paf c16 10 µM 0.053620689862803 0.465809000198135 no 1551 0.478618686048649 2297 13871343 A lipid and platelet activating factor SGTC_2799 7812892 81.82 µM 0.0528401020529553 0.466143235697825 no 1552 0.478929654648568 2287 20205235 SGTC_2212 7123476 200 µM 0.0519706780571087 0.466515537565706 no 1553 0.479276028674698 2289 1085715 SGTC_3302 9125395 16.351 µM 0.0516291514773403 0.466661792981902 no 1554 0.479412095394846 2234 17599668 SGTC_1321 1326-2144 215 µM 0.0514702177574821 0.466729856328519 no 1555 0.479475416585578 2316 3513030 SGTC_3068 9116768 49.47 µM 0.0502095021414407 0.467269791947301 no 1556 0.479977719746194 2249 41904888 SGTC_2081 5214970 32.255 µM 0.047761838375293 0.468318241365552 no 1557 0.480953025195808 2312 2063512 SGTC_1512 0259-0544 12.2 µM 0.0476337163530472 0.468373128165235 no 1558 0.481004080377193 2221 18476 SGTC_286 k060-0067 22.9 µM 0.0476280812239312 0.468375542238685 no 1559 0.481006325919773 2307 5985051 SGTC_2876 9059903 25.97 µM 0.0475437793744593 0.468411657052462 no 1560 0.481039919435367 2321 6916095 SGTC_2482 5981709 142.65 µM 0.0469252815898527 0.46867662871129 no 1561 0.481286389245136 2289 877755 SGTC_2133 5320837 200 µM 0.045900921155165 0.469115507124478 no 1562 0.481694609988538 2315 2841355 SGTC_1659 st012954 42.1 µM 0.0449298994289764 0.469531567685579 no 1563 0.482081592302237 2301 24207262 SGTC_1444 4112-3581 28 µM 0.0440762209598935 0.469897376847928 no 1564 0.482421823642339 2302 2877249 SGTC_977 1348-1378 135 µM 0.0439273526766657 0.46996117090202 no 1565 0.482481156028448 2328 X977 SGTC_3350 9150499 3.57 µM 0.0425842522721269 0.47053676012722 no 1566 0.483016474484445 2344 4910996 YPR165W RHO1 SGTC_2611 pyromycin 23.93 µM 0.0418067068041203 0.470870007503658 no 1567 0.483326394216315 2301 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.041806615119328 0.470870046799952 no 1568 0.483326430761304 2266 676296 Flavone; oxidizing agent. SGTC_423 5-fluorouracil 457 µM 0.0412151199853812 0.471123568739869 no 1569 0.483562199954827 2333 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2536 dehydroabietamide 32.04 µM 0.0400287061449122 0.471632115178942 no 1570 0.48403512021684 2331 3983547 SGTC_1878 temozolomide 1 mM 0.0394622394315955 0.471874942797067 no 1571 0.484260929310143 2340 5394 DNA alkylating agent. SGTC_2674 ligustilide 100 µM 0.038095468777495 0.472460880046125 no 1572 0.484805782040604 2302 5319022 A signalling regulator. SGTC_3179 9107801 49.47 µM 0.0376145374173967 0.472667070500478 no 1573 0.484997508470938 2338 4818259 SGTC_1074 carmofur 3.8 µM 0.0370357304347154 0.472915233030819 no 1574 0.485228258252974 2348 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2183 6420625 130.508 µM 0.0365000540052431 0.473144912777616 no 1575 0.485441817824723 2339 2897619 SGTC_2974 9094440 9.66 µM 0.0344265936884323 0.474034025183041 no 1576 0.486268488670172 2295 25236134 SGTC_2841 9004761 38.96 µM 0.0336956324710548 0.474347496869223 no 1577 0.486559930889871 2307 2991039 SGTC_3207 9114163 49.47 µM 0.0336840749685428 0.474352453415919 no 1578 0.486564539050391 2336 849233 SGTC_3292 9120825 59.784 µM 0.0335663250990982 0.474402951812026 no 1579 0.486611487902837 2352 24824900 SGTC_1779 st039427 55 µM 0.0333549980939248 0.474493582878103 no 1580 0.48669574799736 2357 1124498 SGTC_3052 9092717 49.47 µM 0.0324618033612729 0.474876658671736 no 1581 0.487051888233474 2319 25237534 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0315633381382749 0.475262018320454 no 1582 0.487410140370082 2343 390807 SGTC_2866 9034245 58.44 µM 0.030778474388414 0.47559867224764 no 1583 0.487723103617769 2361 6462273 SGTC_569 4130-2812 160 µM 0.0291651835029288 0.476290720315372 no 1584 0.488366424476988 2370 743552 SGTC_2277 7947813 106.88 µM 0.0290225968509608 0.476351888711402 no 1585 0.488423284251333 2316 1246798 SGTC_2569 tetrandrine 100 µM 0.0284725722331955 0.476587849551829 no 1586 0.488642621672318 2317 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1672 st016598 6.51 µM 0.0268308399753767 0.477292202021502 no 1587 0.489297327662095 2254 4665860 YNL267W PIK1 SGTC_3118 9124250 49.47 µM 0.0253666220355885 0.477920455434184 no 1588 0.489881267146616 2278 1504786 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0247301466893804 0.478193565731063 no 1589 0.490135104424386 2351 4330530 SGTC_998 3996-0085 177 µM 0.0235479356752223 0.478700877189255 no 1590 0.490606600965887 2332 715391 SGTC_2316 5844804 197.44 µM 0.0230569031033257 0.478911599720706 no 1591 0.490802441439728 2350 776813 SGTC_711 k292-0785 179 µM 0.0226112035491352 0.479102873070971 no 1592 0.490980203486707 2363 4146315 SGTC_1773 st048542 73.5835 µM 0.0221182467686714 0.479314432610188 no 1593 0.491176815609888 2337 3237138 SGTC_1634 st006576 41 µM 0.0216613881964071 0.47951050528531 no 1594 0.491359032147901 2362 3915356 SGTC_1362 1611-0397 101 µM 0.021206741557286 0.479705633574388 no 1595 0.491540368253904 2365 27816 SGTC_3019 9081971 49.47 µM 0.0211039733460768 0.479749740999054 no 1596 0.491581357665004 2348 16451803 SGTC_2844 9010103 25.97 µM 0.0209234755449756 0.479827210040493 no 1597 0.49165334997247 2335 2480525 SGTC_2037 5169046 200 µM 0.0196493919657707 0.480374063877748 no 1598 0.492161531167566 2348 5718022 SGTC_3174 9107204 49.47 µM 0.019646305782554 0.480375388554424 no 1599 0.492162762138912 2366 3938802 SGTC_1125 tnp00248 1.32998 µM 0.0195002893652556 0.480438063156813 no 1600 0.492221003103821 2373 24207736 SGTC_3160 9100216 49.47 µM 0.019304088379629 0.480522279234253 no 1601 0.492299261240993 2380 17191039 SGTC_2260 7964312 200 µM 0.0185766312305491 0.480834535924753 no 1602 0.492589422598035 2372 231951 SGTC_3269 9137823 49.47 µM 0.0181496765322824 0.481017809199486 no 1603 0.492759724161971 2364 17682936 SGTC_1548 st061468 90.8 µM 0.0173805861526314 0.481347956693046 no 1604 0.493066498411524 2372 390799 SGTC_1073 triclabendazole 3.09 µM 0.0173397040718489 0.481365506507473 no 1605 0.493082805544595 2345 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3281 9140613 49.47 µM 0.0171124348662898 0.481463069038178 no 1606 0.493173459388337 2329 16013766 SGTC_3145 9085516 49.47 µM 0.0154467803619476 0.482178137690743 no 1607 0.493837871268943 2331 25236195 SGTC_2214 7179297 48.276 µM 0.0145465968001402 0.48256461222284 no 1608 0.494196952158712 2376 769744 SGTC_1555 citronellol 128 µM 0.0132202400139945 0.483134084852165 no 1609 0.49472604092762 2381 8842 A terpine precursor. SGTC_736 0958-0254 92.6 µM 0.0127461753888 0.48333763338657 no 1610 0.494915149409399 2370 6812352 SGTC_200 k038-0079 37.545 µM 0.0119187812229823 0.483692900955893 no 1611 0.495245206815114 2356 3436683 SGTC_3024 9090631 49.47 µM 0.0107354432279251 0.48420102657309 no 1612 0.495717260061801 2386 25236383 SGTC_716 1683-5115 658 µM 0.0105575440765674 0.484277418749927 no 1613 0.495788227532713 2393 723597 SGTC_37 0566-0070 1.56 µM 0.0104183154546781 0.484337205708239 no 1614 0.495843768661828 2385 1626686 SGTC_1348 1493-0373 93.8 µM 0.0101546918904932 0.484450410773243 no 1615 0.495948933683371 2371 3010129 SGTC_2514 salinomycin 42.74 µM 0.0101179147004312 0.484466203710882 no 1616 0.495963604905727 2389 23682228 A polyether potassium ionophore. SGTC_683 panaxydol 45 µM 0.00923490651539143 0.484845394186047 no 1617 0.496315857701621 2382 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_747 3448-8087 38.7 µM 0.00880620089477876 0.485029498335213 no 1618 0.496486879540021 2384 5168703 SGTC_1479 0549-0158 134 µM 0.00841445088144649 0.485197734990221 no 1619 0.496643159389465 2392 5440202 SGTC_1412 3909-8563 178 µM 0.00807850039281759 0.485342010694397 no 1620 0.496777179685811 2396 23767530 SGTC_2284 7945075 39.21 µM 0.00709614197233663 0.485763900623971 no 1621 0.49716907269819 2394 1245402 SGTC_316 k060-0003 58.6 µM 0.00703074158581945 0.485791988463173 no 1622 0.497195163026661 2388 6152314 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.00699497563216731 0.485807349080427 no 1623 0.497209431226911 2390 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3017 9080681 49.47 µM 0.00686157926044646 0.485864639800695 no 1624 0.497262647402372 2379 16451914 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.00549602602503658 0.486451130556975 no 1625 0.497807413882752 2396 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1152 3909-8331 15.9 µM 0.00462465963967623 0.486825388653983 no 1626 0.498155034313796 2396 16001939 SGTC_856 0433-0016 11.3 µM 0.00383974064541036 0.487162526921179 no 1627 0.49846816887489 2388 3911780 SGTC_1430 4049-0248 69.1 µM 0.00329598385149393 0.487396086636683 no 1628 0.498685095066866 2396 22774488 SGTC_1275 0867-0008 21.1 µM 0.00247000289541549 0.487750878268079 no 1629 0.499014612414266 2393 3422836 SGTC_1868 st057644 42.7 µM 0.00192562292281206 0.487984716408457 no 1630 0.499231788074738 2402 688665 SGTC_2176 5809774 33.9695 µM 0.00169048978417145 0.488085719010658 no 1631 0.499325592471723 2400 2870539 SGTC_2655 perillic acid 100 µM 0.00144365949537913 0.488191747003529 no 1632 0.499424063388847 2397 5702197 An apoptosis inducer. SGTC_2804 7954240 19.48 µM 0.000479632465129294 0.488605860716437 no 1633 0.499808654337943 2404 828705 SGTC_511 blebbistatin 171 µM 0.000160544072644119 0.488742933126796 no 1634 0.49993595218183 2403 3476986 A myosin inhibitor. SGTC_907 3448-6986 75.5 µM 0.000107066740955606 0.488765905784463 no 1635 0.49995728655029 2404 590582 SGTC_3259 9138485 49.47 µM 0 0.488811899357734 no 1636 0.5 2406 17646153 SGTC_416 estradiol valerate 100 µM -0.000415377605367986 0.488990338061922 no 1637 0.499834288315652 2408 13791 A steroid. SGTC_75 0159-0059 199.013 µM -0.000625639338654989 0.489080663540784 no 1638 0.499750406031811 2410 5377270 SGTC_16 erodoxin 22.806 µM -0.00163371131057478 0.489513724757811 no 1639 0.499348243774166 2410 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2874 9043904 71.43 µM -0.0018088219675739 0.489588952441185 no 1640 0.499278384832917 2410 4463428 SGTC_2570 licareol 100 µM -0.00279376763571515 0.490012092739944 no 1641 0.498885449418366 2413 443158 SGTC_472 calcifediol 10 µM -0.00301948361187711 0.490109063674535 no 1642 0.498795402152686 2418 5283731 A vitamin D metabolite. SGTC_2622 2-methoxyxanthone 59.94 µM -0.00490531747806604 0.490919268200813 no 1643 0.4980430693072 2424 71034 A hepatoprotective. SGTC_1045 1348-1485 165 µM -0.0053522450634188 0.491111285828148 no 1644 0.497864773343609 2420 6810614 SGTC_2463 5473429 200 µM -0.00822035736616055 0.492343586527611 no 1645 0.496720588820643 2448 5399405 SGTC_2703 st077852 53.4 µM -0.00826792282596779 0.492364023945381 no 1646 0.496701613592486 2430 6281836 SGTC_715 0868-0130 184 µM -0.00930253599545501 0.492808570328621 no 1647 0.496288878601528 2429 2876258 SGTC_3324 9138759 60.749 µM -0.0100910111564558 0.493147363634692 no 1648 0.495974337319006 2467 45595710 SGTC_2938 9059746 27.26 µM -0.0103327425924805 0.493251232197685 no 1649 0.495877905457114 2432 6471769 SGTC_2540 epiandrosterone 100 µM -0.0110077337668331 0.493541268713916 no 1650 0.495608638272885 2423 441302 A steroid. SGTC_1257 0669-0121 16 µM -0.0114559173607719 0.49373385032496 no 1651 0.495429850167142 2437 4307855 SGTC_1203 3992-3522 103 µM -0.0127746151238459 0.49430049458375 no 1652 0.494903804520315 2427 5322312 SGTC_2384 9036245 200 µM -0.0131506204501112 0.494462066180925 no 1653 0.494753812700947 2482 6462766 SGTC_2487 5918373 44.05 µM -0.0135750235443021 0.494644435660416 no 1654 0.494584515479966 2427 2876279 SGTC_62 0180-0423 3.232 µM -0.0144642931966639 0.495026565685336 no 1655 0.494229783091832 2448 30102 YGL099W LSG1 SGTC_1206 3978-0017 132 µM -0.014948253086219 0.495234531097579 no 1656 0.494036731908904 2485 3873677 SGTC_2371 9071574 200 µM -0.0150063521781191 0.495259497307667 no 1657 0.49401355632421 2437 45596039 SGTC_1504 k297-0033 30 µM -0.015448046935924 0.495449301977987 no 1658 0.493837366039316 2432 4388117 SGTC_2252 omeprazole 400 µM -0.0157635606247926 0.495584884867195 no 1659 0.493711509615843 2489 4594 A proton pump inhibitor. SGTC_84 0443-0269 128.823 µM -0.017701703664328 0.496417756424281 no 1660 0.492938410766954 2431 6150058 SGTC_1671 st016596 74.5 µM -0.0179929664274463 0.496542921210364 no 1661 0.492822232240944 2453 2829167 SGTC_278 4092-0821 23.9 µM -0.0181549914267685 0.496612548605568 no 1662 0.492757604175149 2455 877900 SGTC_1130 3454-2858 15.9 µM -0.0187704521021432 0.496877032933975 no 1663 0.492512112737847 2488 715628 YIL048W NEO1 SGTC_2199 6590217 200 µM -0.0190146648492363 0.496981979821882 no 1664 0.492414703333521 2449 703109 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.019299638660357 0.497104443449726 no 1665 0.492301036091494 2471 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1214 0358-0031 63.7 µM -0.0203054525825385 0.49753668043583 no 1666 0.491899853076456 2479 4301366 SGTC_932 2857-0803 154 µM -0.0206313864235134 0.497676747407088 no 1667 0.491769851522584 2563 674898 SGTC_1063 disulfiram 1.84 µM -0.0206526014918543 0.497685864391243 no 1668 0.491761389737782 2452 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_203 k066-0004 30.888 µM -0.0206794121864143 0.497697386046995 no 1669 0.491750696101939 2427 6795412 SGTC_183 3914-0051 30.55 µM -0.0225827649822703 0.498515339191214 no 1670 0.490991545937191 2444 1596232 SGTC_784 4579-0127 173 µM -0.022674292753702 0.498554672824095 no 1671 0.490955040986731 2490 1948547 SGTC_3323 9138564 53.9225 µM -0.0229323882044195 0.498665588214689 no 1672 0.490852102566421 2443 43912313 YNL103W MET4 SGTC_1534 6-azauridine 81.6 µM -0.0229937802798602 0.498691971205982 no 1673 0.490827617128326 2447 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2303 7774051 200 µM -0.0231197705971938 0.49874611504317 no 1674 0.490777367622322 2479 2953184 SGTC_3247 9135149 49.47 µM -0.023949478747575 0.499102679347448 no 1675 0.490446453626005 2448 8934436 YOR116C RPO31 SGTC_1277 0873-0036 22 µM -0.0240248901953668 0.499135087204884 no 1676 0.490416377464993 2471 5965735 SGTC_845 0330-0138 4.51 µM -0.0240738227607642 0.499156115840206 no 1677 0.490396861840226 2432 9039800 SGTC_554 4483-2211 187 µM -0.0260170661129393 0.49999122060912 no 1678 0.489621863134338 2493 747107 SGTC_440 fluspirilene 35.1 µM -0.026057924411784 0.49999122060912 no 1679 0.489605568555825 2633 3396 An atypical antipsychotic. SGTC_2705 st078069 42.8 µM -0.0267980697971952 0.499673144473627 no 1680 0.489310396372563 2481 1530061 SGTC_1713 st033146 12.748 µM -0.027583401630328 0.499335649775961 no 1681 0.488997210104587 2455 674619 SGTC_794 k038-0031 316 µM -0.0283799568814638 0.498993332324972 no 1682 0.488679554926905 2445 6624242 SGTC_3249 9135183 49.47 µM -0.0290640862352187 0.498699330179547 no 1683 0.488406739361175 2555 4902779 SGTC_1454 4239-0054 42.6 µM -0.0292780715778268 0.498607370880639 no 1684 0.488321407875003 2560 1340767 SGTC_2370 9071495 200 µM -0.0293308421113609 0.498584692977497 no 1685 0.488300364515464 2504 21791103 SGTC_3060 1327-0027 12.5 µM -0.0298174009488047 0.498375596696324 no 1686 0.48810634049326 2459 16000455 YPR107C YTH1 SGTC_1344 1488-0097 29.1 µM -0.0302055473359503 0.498208793001646 no 1687 0.487951562208628 2491 747966 SGTC_1723 st034307 2.5525 µM -0.0304614729338046 0.498098810606059 no 1688 0.48784950962849 2479 867466 SGTC_775 4577-0580 57.3 µM -0.0305222377241065 0.498072697345377 no 1689 0.487825279251237 2599 2006902 SGTC_788 1182-0090 188 µM -0.0314952244045462 0.497654564052674 no 1690 0.487437300315191 2587 5715185 SGTC_1282 0886-0010 32.4 µM -0.0319626487869486 0.497453693027306 no 1691 0.487250918808971 2475 2836211 YNL267W PIK1 SGTC_2567 aureobasidin a 60 nM -0.0328123117973243 0.497088560404489 no 1692 0.486912130052872 2558 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1032 k061-1018 98.7 µM -0.0341913816697758 0.496495926775387 no 1693 0.486362269477805 2601 4005393 SGTC_1740 st038286 13.222 µM -0.0342688864293205 0.496462620538938 no 1694 0.486331367661464 2499 716786 SGTC_219 mitoxanthrone 164.414 µM -0.0343041609260265 0.496447461984765 no 1695 0.486317303442445 2520 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_467 ro 31-8220 72.8 µM -0.0344980859288046 0.49636412643976 no 1696 0.486239984324434 2465 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1715 st032160 10.2275 µM -0.0345971798762799 0.496321542780266 no 1697 0.486200475143979 2483 5289825 SGTC_2683 piperine 63.03 µM -0.0347702083994571 0.496247187303316 no 1698 0.486131488257122 2469 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2411 st077133 39.94 µM -0.0351890053235441 0.496067218416039 no 1699 0.48596451464187 2669 1403142 YNL221C POP1 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0353148934727035 0.496013120871387 no 1700 0.485914323732413 2441 368090 SGTC_359 0081-0058 15.9 µM -0.0358927798959176 0.495764788391797 no 1701 0.485683926484013 2509 3494159 SGTC_1825 st052143 62.6 µM -0.0366084407564896 0.495457253021069 no 1702 0.485398606646352 2483 674173 SGTC_1287 0971-0001 34.6 µM -0.0373170833038257 0.495152736235026 no 1703 0.485116092236429 2473 4665869 SGTC_1148 3909-7663 27.7 µM -0.0375620269912892 0.495047480058073 no 1704 0.485018442306359 2570 4084526 SGTC_1738 st035555 74 µM -0.0376333110910747 0.495016848217288 no 1705 0.48499002415787 2518 5331140 SGTC_1705 st027868 56.3335 µM -0.0378248578040048 0.494934537884131 no 1706 0.484913662444705 2545 292948 SGTC_2296 7971656 126.45 µM -0.0381800486367638 0.494781907930276 no 1707 0.484772064088788 2487 666570 SGTC_2644 guaiazulene 100 µM -0.0383914735352727 0.494691056361996 no 1708 0.484687779552558 2485 3515 A coloring agent. SGTC_2395 5646831 180.19 µM -0.0385758808470314 0.494611814767963 no 1709 0.484614266135789 2510 6808628 SGTC_2213 7173844 200 µM -0.0391420963301985 0.494368507875561 no 1710 0.48438854932566 2466 892728 SGTC_1442 4112-3290 3 µM -0.0391486504037718 0.494365691554787 no 1711 0.484385936631165 2459 704353 SGTC_67 0335-0847 266 µM -0.0409773795749091 0.493579888242816 no 1712 0.483656964598218 2601 4552207 YOR254C SEC63 SGTC_256 clotrimazole 625 nM -0.0417014057231168 0.493268781559946 no 1713 0.483368366666318 2465 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_670 4204-0025 119 µM -0.0421664554740464 0.493068956552426 no 1714 0.483183001709444 2532 719039 SGTC_2146 5545642 200 µM -0.0426104730962649 0.492878170362228 no 1715 0.483006023375326 2475 825326 SGTC_2777 climbazole 1.536 µM -0.0426451021030598 0.492863290984048 no 1716 0.482992220946478 2477 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_561 1550-0330 72.9 µM -0.0426651103402789 0.492854693856981 no 1717 0.48298424607297 2495 6812934 SGTC_2126 5251174 33.877 µM -0.0426950096434165 0.492841846748979 no 1718 0.482972328835884 2485 790722 SGTC_2744 captopril 92.04 µM -0.0430879351948184 0.492673015515874 no 1719 0.482815718344131 2503 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_86 0417-1630 471.922 µM -0.0431145233634565 0.492661591227519 no 1720 0.48280512104746 2465 3634867 SGTC_1591 genipin 88.4 µM -0.0431602201850743 0.492641956430549 no 1721 0.482786907607208 2607 442424 A DNA cross-linking agent. SGTC_3099 9120367 49.47 µM -0.0433516326473817 0.492559711411668 no 1722 0.482710616489719 2497 24824940 SGTC_1820 st053765 18.6 µM -0.0439166357059454 0.492316945966727 no 1723 0.482485427359198 2524 3690829 SGTC_2780 5215298 71.43 µM -0.0445873336443241 0.492028770195422 no 1724 0.482218119453647 2492 2834131 SGTC_1445 4239-0156 97.7 µM -0.0446915760450039 0.491983981200997 no 1725 0.482176574166503 2564 4008346 SGTC_333 3486-0131 40.1 µM -0.0447071298811391 0.491977298317894 no 1726 0.482170375279528 2579 6744690 SGTC_1328 1441-0025 69.2 µM -0.0452181705877637 0.491757725112899 no 1727 0.481966705514413 2483 4562601 SGTC_2913 7966556 36.57 µM -0.0452978345692688 0.491723496994886 no 1728 0.481934956715952 2479 2976516 SGTC_802 4112-3352 742 µM -0.0457380468821812 0.491534358181706 no 1729 0.481759519250508 2616 704594 SGTC_2075 5212009 200 µM -0.0457849052997531 0.491514225404376 no 1730 0.481740845009769 2501 780898 SGTC_2793 7325131 81.82 µM -0.0498164495036564 0.489782153809855 no 1731 0.480134329075012 2544 4176441 SGTC_1970 st070122 35.8 µM -0.050055083760904 0.48967963513666 no 1732 0.480039246402565 2553 102928 SGTC_1787 fluconazole 80 µM -0.0503259445795664 0.489563272570645 no 1733 0.479931324588127 2518 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_837 0091-0265 12.5 µM -0.0512691285357522 0.489158085098646 no 1734 0.479555533799968 2496 759367 SGTC_3087 9117406 49.47 µM -0.0520256145715403 0.488833110257322 no 1735 0.479254141785331 2597 42546093 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0527434599141908 0.48852474171916 no 1736 0.478968155595843 2563 6708739 YPR165W RHO1 SGTC_1169 aniline yellow 25.8 µM -0.0528349681302764 0.488485432550406 no 1737 0.478931699930381 2532 6051 A DNA damaging agent. SGTC_3048 9093155 49.47 µM -0.0529726634165269 0.488426283020719 no 1738 0.478876844278041 2493 25236002 SGTC_942 3253-1115 227 µM -0.0554712635888225 0.487353009109543 no 1739 0.477881511511754 2558 46497897 SGTC_1025 k007-0731 70 µM -0.0559373754679508 0.487152800616718 no 1740 0.477695848055202 2508 6256118 SGTC_1254 0550-0035 264 µM -0.0563905148581337 0.486958167285381 no 1741 0.477515356489973 2566 15121435 SGTC_2221 6807166 181.081 µM -0.0576377884643778 0.48642245202996 no 1742 0.477018574425114 2520 674925 SGTC_847 0342-0274 5.54 µM -0.0577919402789704 0.486356244117825 no 1743 0.476957179088038 2515 18097 SGTC_3173 9105693 49.47 µM -0.0580517126515331 0.486244673228071 no 1744 0.476853718603033 2572 17096658 SGTC_1812 st052057 4.327 µM -0.059291646379194 0.485712143094412 no 1745 0.476359907317208 2502 3645418 SGTC_3131 9127911 49.47 µM -0.0598305722697569 0.485480691614844 no 1746 0.476145288017618 2640 45595681 SGTC_1640 st009078 66.4 µM -0.0603590712608812 0.485253722905722 no 1747 0.475934827797382 2536 690618 SGTC_1332 1480-0653 17.5 µM -0.0605934813156553 0.485153054896005 no 1748 0.475841482571449 2496 5749438 SGTC_3021 9087658 49.47 µM -0.061259902769852 0.484866863653987 no 1749 0.475576111875281 2526 25237042 SGTC_986 1493-0483 84 µM -0.0629742466036377 0.484130683747045 no 1750 0.474893505919546 2504 40079 SGTC_1309 pyrazolanthrone 13.4 µM -0.0630828979103996 0.484084028095062 no 1751 0.474850246331413 2540 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1052 3253-3998 198 µM -0.0638172992530532 0.483768676627001 no 1752 0.474557851762234 2506 5450317 SGTC_490 phenamil 164 µM -0.0641876355429105 0.483609658298795 no 1753 0.47441041125 2593 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1002 4049-0206 172 µM -0.0644178695975114 0.483510799641494 no 1754 0.474318750848188 2543 4662749 SGTC_118 0083-0097 135.343 µM -0.0647006693861188 0.483389371523935 no 1755 0.474206164924036 2534 5207356 SGTC_2667 digitoxin 100 µM -0.0650913775306369 0.483221612427332 no 1756 0.474050622804312 2533 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1670 st016595 4.04 µM -0.0665127586542475 0.482611336599001 no 1757 0.473484800133272 2515 597879 SGTC_1361 1608-0041 5.61 µM -0.0669056701295604 0.482442645568547 no 1758 0.473328399522455 2536 X1361 SGTC_2950 9072895 21.46 µM -0.0685477582274238 0.48173767244231 no 1759 0.472674801941516 2570 17332245 SGTC_1245 0418-0076 17.2 µM -0.0689210695922416 0.481577412144106 no 1760 0.472526223643176 2610 6790114 SGTC_750 4073-0104 132 µM -0.0694153512018296 0.481365224640409 no 1761 0.472329504950818 2540 22330957 SGTC_1739 st037196 92.5 µM -0.0724349463538316 0.480069075672887 no 1762 0.471127887329019 2551 612214 SGTC_1429 4049-0205 9.46 µM -0.0727477103606698 0.479934834800691 no 1763 0.471003440861128 2530 22774478 SGTC_1137 ixabepilone 100 µM -0.0731816389713809 0.479748592860741 no 1764 0.470830788592077 2532 154225 A novel microtubule stabilizer. SGTC_419 nsc-638432 893 µM -0.073981504814005 0.479405302461718 no 1765 0.470512550973076 2590 368090 SGTC_2402 5553605 200 µM -0.0740685812126521 0.479367931497498 no 1766 0.470477907564056 2610 6758546 SGTC_706 4262-0057 46.9 µM -0.0741002696563826 0.479354331672548 no 1767 0.470465300348931 2527 883298 SGTC_2066 5222451 176 µM -0.0744580294192015 0.479200792507576 no 1768 0.470322968047729 2534 2281147 SGTC_1184 1269-1718 139 µM -0.0750838999362422 0.478932196130309 no 1769 0.47007397882585 2611 5403821 SGTC_906 1165-0455 526 µM -0.0756118961124443 0.478705610594134 no 1770 0.469863935915674 2528 3252859 SGTC_1436 4092-1007 8.32 µM -0.0758733528034209 0.478593410990454 no 1771 0.469759928558001 2555 2881121 SGTC_2200 6600604 21.907 µM -0.0761882668647185 0.478458273336555 no 1772 0.469634658621496 2538 2904777 SGTC_1307 1187-1599 12.2 µM -0.0770367405366055 0.478094184017095 no 1773 0.46929715853915 2549 1538471 SGTC_1770 st043884 66.3 µM -0.0771109730009551 0.478062330921179 no 1774 0.469267631900639 2542 670149 SGTC_1974 st069448 26.9 µM -0.0778745234003027 0.47773470017618 no 1775 0.468963932617066 2569 6323587 YNR016C ACC1 SGTC_1516 st013856 110 µM -0.0779142645596018 0.477717648109235 no 1776 0.468948126214128 2687 5281404 A mutagen and neurotoxin. SGTC_373 0844-0104 25.9 µM -0.0781270266415046 0.477626357222806 no 1777 0.46886350437243 2575 5375804 SGTC_2204 7233102 200 µM -0.0788443807446241 0.477318567204148 no 1778 0.468578201584812 2541 2172480 SGTC_539 4859-0462 2.54 µM -0.0788858763546913 0.477300763390296 no 1779 0.468561698633165 2612 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_177 1327-0068 8.361 µM -0.0789108322200532 0.477290056024494 no 1780 0.468551773622801 2543 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_49 0717-0965 32.132 µM -0.0805119606181558 0.476603123171649 no 1781 0.467915041959721 2821 5889349 YGL099W LSG1 SGTC_870 0573-2213 57.6 µM -0.0810849757291825 0.476357299021588 no 1782 0.467687186986293 2544 3916321 SGTC_2948 9070189 9.45 µM -0.0820938834033703 0.475924498379411 no 1783 0.467286028522407 2595 6473636 YDL196W YDL196W SGTC_1207 2099-0101 141 µM -0.0822523853411217 0.47585650687656 no 1784 0.467223008526426 2608 5837381 SGTC_1648 st011736 69.8 µM -0.0845062379610024 0.474889763993113 no 1785 0.466326971704322 2662 2855514 SGTC_2012 4023501 200 µM -0.0850371089961035 0.474662079278359 no 1786 0.466115944415332 2609 3477460 SGTC_1769 st044406 64.4 µM -0.085836693323952 0.474319162046437 no 1787 0.465798118527353 2565 670903 SGTC_1887 st057648 70.8 µM -0.0868962857751339 0.473864764647185 no 1788 0.465376975938053 2680 688672 SGTC_682 0kpi-0099 17 µM -0.0897916330279566 0.472623294212989 no 1789 0.464226398604428 2639 1714895 YML126C ERG13 SGTC_2558 carylophyllene oxide 100 µM -0.0903321286472501 0.472391568949506 no 1790 0.464011644770075 2548 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2076 5212012 200 µM -0.0904213106061314 0.472353335099132 no 1791 0.463976211321282 2542 604802 SGTC_1327 1436-0082 2.18 µM -0.0906917920048657 0.47223737659827 no 1792 0.46386874639266 2626 15992205 SGTC_178 4092-0806 87.505 µM -0.0909350213617618 0.472133103371763 no 1793 0.463772111220048 2563 2169044 SGTC_3253 9135987 49.47 µM -0.0911564430724621 0.472038180815586 no 1794 0.463684142096992 2643 4182430 SGTC_297 0986-0032 24 µM -0.0915331636218209 0.471876685952963 no 1795 0.463534478036073 2564 2847425 SGTC_1291 0993-0025 5.79 µM -0.0917817571980531 0.471770119873232 no 1796 0.46343571926131 2644 4353356 SGTC_2640 pentamidine 10.38 µM -0.0920420379799732 0.471658545935766 no 1797 0.463332319924905 2612 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3186 9110464 49.47 µM -0.0926351647231078 0.471404300043109 no 1798 0.463096703220251 2664 17018021 SGTC_1569 carminic acid 40.6 µM -0.0946832311581486 0.470526479308127 no 1799 0.462283218864654 2598 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2416 tofa 880 nM -0.0950952356429139 0.470349907435207 no 1800 0.462119591166964 2625 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_476 mead acid 10 µM -0.0955100556392667 0.470172134814107 no 1801 0.46195485176473 2576 5312531 An omega 9 fatty acid. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0973301876849502 0.469392181332664 no 1802 0.461232091747904 2556 5355888 SGTC_1183 1254-0324 198 µM -0.0995174775400527 0.468455050924514 no 1803 0.460363705856385 2671 5799357 SGTC_3226 9131256 49.47 µM -0.0997967026767912 0.468335431163571 no 1804 0.460252862933062 2559 17178073 SGTC_2227 7312221 64.1025 µM -0.100142423605866 0.468187328635881 no 1805 0.46011562771259 2594 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2850 9015429 58.44 µM -0.102145605441333 0.467329277865238 no 1806 0.459320551194988 2633 6457570 SGTC_1987 st072290 61.9 µM -0.102917926874327 0.46699849899569 no 1807 0.459014054832312 2639 54697379 SGTC_2021 4019055 173 µM -0.103580279615515 0.466714836950474 no 1808 0.458751219028855 2693 44827708 YER133W GLC7 SGTC_2147 5545932 89.7195 µM -0.104117237761343 0.466484889337204 no 1809 0.45853815572488 2612 797404 SGTC_1072 oxiconazole 14.9 nM -0.104989151011968 0.466111524004735 no 1810 0.458192208689651 2591 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2742 clothiapine 36.27 µM -0.105787874486715 0.465769525713619 no 1811 0.457875328780098 2579 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2975 9084847 53.72 µM -0.105865302872507 0.46573637368268 no 1812 0.457844611809564 2708 27211724 SGTC_3300 9124615 50.48 µM -0.105910781692045 0.465716901409878 no 1813 0.45782656981556 2738 24824903 SGTC_1562 morin hydrate 59.1 µM -0.107286295822049 0.465127998418871 no 1814 0.457280928069541 2727 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1540 guanosine 70.6 µM -0.108099524319417 0.46477986430175 no 1815 0.456958372741044 2575 6802 Guanosine is a purine nucleoside SGTC_2231 micatex 6.853 µM -0.108318448907996 0.464686149703381 no 1816 0.456871544302713 2618 20737 An antifungal of unknown mechanism. SGTC_1435 4092-0789 56.7 µM -0.109573238807328 0.464149052318624 no 1817 0.456373917586469 2604 2248285 SGTC_452 diindolylmethane 8 µM -0.109882420767341 0.46401672077659 no 1818 0.4562513121537 2687 3071 Inhibits expression of several cancer promoting factors. SGTC_848 0368-0089 85.6 µM -0.110399808750093 0.463795284848323 no 1819 0.456046152399084 2602 762535 SGTC_108 0509-0257 621.132 µM -0.111222282994177 0.463443298726479 no 1820 0.455720040991847 2687 536624 SGTC_961 1252-1571 372 µM -0.111238575534752 0.463436326458071 no 1821 0.455713581292783 2668 6813498 SGTC_617 3770-0098 35 µM -0.11143925984731 0.463350446059778 no 1822 0.455634014536025 2619 5962639 SGTC_914 3820-6779 408 µM -0.112145370677015 0.463048288165602 no 1823 0.455354071848961 2608 2893481 SGTC_714 4296-0578 26.1 µM -0.113622752524155 0.462416158293117 no 1824 0.454768425124023 2637 1589775 SGTC_1039 k821-0043 94 µM -0.113907108640772 0.462294501202662 no 1825 0.454655715183771 2594 15992768 SGTC_2782 7736369 71.43 µM -0.114195181391185 0.462171257608319 no 1826 0.454541535807781 2647 2950836 YOL077C BRX1 SGTC_965 1291-5240 308 µM -0.11478440456202 0.461919186841021 no 1827 0.454308005350669 2682 2834598 SGTC_1935 st074532 41.6 µM -0.116386756051929 0.461233775540577 no 1828 0.453673015599702 2748 2829742 SGTC_3197 9113331 49.47 µM -0.11681129812314 0.461052195435943 no 1829 0.453504795220397 2739 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_850 0388-0143 75.9 µM -0.117534891784767 0.46074272726254 no 1830 0.453218098001579 2626 67273 SGTC_3154 9100113 49.47 µM -0.117802942698778 0.460628092666423 no 1831 0.453111898924653 2630 25237525 SGTC_207 4185-0010 4.486 µM -0.118223903605395 0.460448071223619 no 1832 0.452945125217509 2621 3761753 SGTC_445 e6 berbamine 66 µM -0.118388419811082 0.460377719042039 no 1833 0.452879950451351 2699 6610268 A calcium/calmodulin antagonist. SGTC_2499 avocadenofuran 51.48 µM -0.120286490965287 0.459566135788896 no 1834 0.452128102529284 2621 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2162 5663267 200 µM -0.120863184257615 0.459319584663358 no 1835 0.451899701524539 2633 6456493 SGTC_604 1000-0114 314 µM -0.121505818159649 0.459044860676101 no 1836 0.451645203312377 2683 1572745 SGTC_52 0329-0193 875 nM -0.122364190849611 0.458677939561101 no 1837 0.451305298457567 2843 3739292 SGTC_577 r071-0003 38.6 µM -0.122877388413983 0.458458584253041 no 1838 0.45110209567411 2618 4568517 YMR134W ERG29 SGTC_760 0568-0725 82.9 µM -0.123401778458836 0.458234458026 no 1839 0.450894474416122 2771 3916171 SGTC_3208 9114115 49.47 µM -0.126050640813547 0.457102528946825 no 1840 0.449845919324745 2706 650895 SGTC_3062 9077494 49.47 µM -0.126825635752777 0.456771418453169 no 1841 0.449539202587992 2715 16459633 SGTC_1262 0737-0114 49.6 µM -0.127662287389007 0.456413999313878 no 1842 0.449208118063475 2642 765919 SGTC_2921 7974240 10.71 µM -0.127739551396276 0.456380993760081 no 1843 0.449177544492952 2752 2979074 YDR527W RBA50 SGTC_1674 st016616 23.6 µM -0.128923618433745 0.455875223084107 no 1844 0.448709043910539 2604 625830 SGTC_1559 coumarin 343 70.1 µM -0.129084654014235 0.455806442724656 no 1845 0.448645332366609 2756 108770 A hepatotoxic, DNA x-linker. SGTC_3192 9110362 49.47 µM -0.129125899353435 0.455788826524859 no 1846 0.44862901442038 2620 16649480 SGTC_1837 st055472 66.5 µM -0.129375215014594 0.455682343751155 no 1847 0.448530379198266 2780 676091 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.131067962141598 0.454959455649319 no 1848 0.447860772498003 2746 23847180 SGTC_1690 st023502 41.2 µM -0.131606060436157 0.454729691755592 no 1849 0.447647945845408 2715 24207482 SGTC_2740 felodipine 17.08 µM -0.132560384967445 0.454322239709827 no 1850 0.447270532031989 2716 3333 L-type calcium channel blocker SGTC_486 niguldipine 82 µM -0.133878202644562 0.453759672147364 no 1851 0.44674944343552 2618 1236 A calcium channel blocker. SGTC_134 0269-0018 6.916 µM -0.134418272446925 0.4535291466919 no 1852 0.446535916715986 2739 4378915 SGTC_2877 9040724 71.43 µM -0.135707315852002 0.452978989913201 no 1853 0.446026332008237 2786 6463895 SGTC_544 k015-0020 52.4 µM -0.135881151024254 0.452904804880881 no 1854 0.445957618281035 2688 3008304 SGTC_762 1165-0429 115 µM -0.136966392183783 0.452441710032565 no 1855 0.445528679930296 2752 5967793 SGTC_790 1575-0012 79.1 µM -0.137208228450281 0.452338522287453 no 1856 0.445433103531837 2660 378741 YLR208W SEC13 SGTC_1377 2944-0135 198 µM -0.137403276877217 0.452255300525137 no 1857 0.445356020521201 2731 1894137 SGTC_2437 5741531 144.16 µM -0.137620064784328 0.452162805590196 no 1858 0.445270348506382 2780 2262990 SGTC_2452 5863136 48.41 µM -0.138216585937134 0.451908306722789 no 1859 0.445034623612197 2627 2184096 SGTC_382 3229-0966 23.2 µM -0.138461955808821 0.451803628228137 no 1860 0.444937667411252 2794 5722370 SGTC_2932 9016711 44.54 µM -0.13862995880201 0.451731957544916 no 1861 0.444871284094555 2710 7117328 SGTC_2273 7815444 169.05 µM -0.138812500693562 0.451654086298512 no 1862 0.444799157750115 2770 2824616 SGTC_1645 Cervolide 78 µM -0.140120350658141 0.451096220146275 no 1863 0.44428245085774 2717 23173 A fragrance. SGTC_780 0109-0199 192 µM -0.140510565594812 0.450929791801623 no 1864 0.444128302584313 2849 610414 SGTC_3076 9116187 49.47 µM -0.140712945066055 0.4508434794842 no 1865 0.444048359084098 2762 27241210 SGTC_2322 7413319 38.22 µM -0.141620212949147 0.450456569685845 no 1866 0.44369000011576 2767 1840400 SGTC_1107 amlodipine 47 µM -0.142442718860238 0.450105847812247 no 1867 0.443365160802322 2703 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_900 1112-0045 141 µM -0.143592327883253 0.449615712390912 no 1868 0.442911199666517 2689 56211 YIL048W NEO1 SGTC_2978 9011784 42.97 µM -0.143949000621099 0.449463660675852 no 1869 0.442770370845106 2816 2994934 SGTC_93 0109-0045 59.227 µM -0.14501128571652 0.449010846251094 no 1870 0.442350980632273 2621 88733 SGTC_883 0850-0245 24.6 µM -0.14528697343468 0.448893341193099 no 1871 0.442242149645586 2868 6823229 YPR165W RHO1 SGTC_618 k072-0232 33.2 µM -0.145320583240322 0.448879016152685 no 1872 0.442228882075321 2747 5872756 YGL099W LSG1 SGTC_2998 9066762 71.4286 µM -0.145814089522129 0.448668683511052 no 1873 0.442034076478865 2800 4945196 SGTC_703 3875-0075 71.8 µM -0.14618008953843 0.448512703421889 no 1874 0.44188961147879 2687 2850814 SGTC_645 0845-0943 5.41 µM -0.146674884600159 0.448301846749873 no 1875 0.441694321678149 2719 1885106 SGTC_2564 betulinic acid 100 µM -0.146718114172942 0.448283425181587 no 1876 0.441677260145932 2864 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1209 2323-2347 50.3 µM -0.147447214265032 0.447972748054994 no 1877 0.441389520572196 2658 5412760 SGTC_2647 atorvastatin 60.16 µM -0.147852844917924 0.447799918421248 no 1878 0.441229451692918 2751 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2045 5106652 78.05 µM -0.147962807336294 0.447753067739773 no 1879 0.441186060271429 2779 673349 SGTC_2972 9093619 59.92 µM -0.148508245069758 0.447520688862223 no 1880 0.44097083974172 2684 25236256 SGTC_2027 5150920 200 µM -0.148905493986087 0.447351455839329 no 1881 0.440814102987819 2751 786715 SGTC_2585 alliin 100 µM -0.14955595276679 0.447074372947013 no 1882 0.440557480913275 2820 87310 A garlic compound which reacts with lipids. SGTC_395 anisomycin 6.25 µM -0.149936486596605 0.446912284844433 no 1883 0.440407362473964 2724 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2186 6124449 200 µM -0.150117751851908 0.446835078159815 no 1884 0.440335857368332 2807 3834182 YLR033W RSC58 SGTC_2398 5228213 48.84 µM -0.150282076454041 0.446765088783839 no 1885 0.440271036654414 2755 80771 YMR134W ERG29 SGTC_2597 laccaic acid a 100 µM -0.150492003771 0.446675678645049 no 1886 0.440188229480826 2774 5491415 A textile dye. SGTC_385 1494-0393 12.4 µM -0.151168297986051 0.446387656646142 no 1887 0.439921478706848 2714 3090647 SGTC_2180 6301957 200 µM -0.151490489724543 0.446250450699378 no 1888 0.439794406180212 2698 845462 SGTC_2243 6634756 200 µM -0.152384294048842 0.445869856216222 no 1889 0.439441921971474 2960 885676 SGTC_3061 glucosamine 200 µM -0.152813581075879 0.445687077454689 no 1890 0.439272643689885 2665 91431 and experimental redox chemotherapeutic SGTC_916 4466-0038 42 nM -0.153535401046182 0.445379772148453 no 1891 0.438988037625913 2743 5722064 YGL116W CDC20 SGTC_1035 k081-0041 55.2 µM -0.153686436079937 0.445315475125835 no 1892 0.438928490077272 2655 731709 SGTC_1375 2910-0797 186 µM -0.153751704394342 0.445287690240629 no 1893 0.43890275761347 2751 742508 SGTC_216 k038-0035 28.382 µM -0.154940928995227 0.444781481539775 no 1894 0.438433943288551 2661 4444231 YPR107C YTH1 SGTC_1370 2001-0092 44.6 µM -0.155630973477705 0.444487796484695 no 1895 0.438161954554372 2798 790957 SGTC_460 trequinsin 123 µM -0.155673071676876 0.444469880346262 no 1896 0.438145362023355 2689 5537 A vasodilator. SGTC_894 0960-0238 55.9 µM -0.155706400735535 0.444455696256372 no 1897 0.438132225827417 2657 6741907 YDL195W SEC31 SGTC_2910 7948405 25.97 µM -0.156094036590847 0.444290732475582 no 1898 0.437979449429135 2774 2971328 SGTC_2245 6637752 200 µM -0.156505714789995 0.444115547711305 no 1899 0.437817207500405 2853 681890 SGTC_1984 st072354 53.1 µM -0.156510838800773 0.444113367318148 no 1900 0.437815188199158 2686 5762938 SGTC_2811 7967822 32.47 µM -0.157382061612909 0.443742665138403 no 1901 0.437471875017087 2802 2232244 SGTC_3213 9129884 49.47 µM -0.157560553664881 0.443666723475447 no 1902 0.437401544420526 2791 17190742 SGTC_1399 3562-5772 25 µM -0.157803319797916 0.443563438926279 no 1903 0.437305891308373 2668 23847490 SGTC_2287 7945887 168.79 µM -0.157956321180098 0.443498346647706 no 1904 0.437245608593997 2779 1245853 SGTC_2319 6033012 152.6 µM -0.159115280767296 0.443005333283449 no 1905 0.436789024642248 2714 847246 SGTC_1637 st007924 17.4 µM -0.159923635984832 0.442661516768585 no 1906 0.436470614661822 2672 683336 SGTC_1862 st057513 3.81 µM -0.160065753101169 0.442601074763632 no 1907 0.43641463917859 2709 5393163 SGTC_198 3454-2873 16.191 µM -0.160205719682743 0.442541548680748 no 1908 0.436359511968239 2703 710957 SGTC_2166 5933061 31.504 µM -0.162500734478096 0.441565692808945 no 1909 0.43545577496689 3209 2877375 SGTC_3143 9086658 49.47 µM -0.163302715156665 0.441224768484008 no 1910 0.435140048107511 2786 25236626 SGTC_2713 st079149 53.4 µM -0.163628209539476 0.441086412282538 no 1911 0.435011918003127 2767 3103253 SGTC_2779 methotrexate 400 µM -0.16531733292616 0.440368541246841 no 1912 0.434347108410931 2702 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3144 9087057 49.47 µM -0.165572315708254 0.440260191496488 no 1913 0.434246767701341 2664 17249618 SGTC_1451 4152-0210 104 µM -0.167068258185125 0.439624611514688 no 1914 0.433658170627904 2834 659563 SGTC_3229 9132204 49.47 µM -0.167301754790708 0.439525419979573 no 1915 0.433566311738267 2681 17682924 SGTC_1097 itavastatin 7.23 µM -0.167551009850846 0.439419538295704 no 1916 0.433468257343079 2722 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3080 9117754 49.47 µM -0.169587919237901 0.438554437516081 no 1917 0.432667111987411 2893 9550191 SGTC_1944 st076371 56.9 µM -0.170629332025712 0.43811224966307 no 1918 0.432257616259515 2709 24208455 SGTC_113 0099-0221 2.5 µM -0.172673838124362 0.437244369779916 no 1919 0.431453904507754 2763 89219 SGTC_2893 9048488 25.97 µM -0.173077220330605 0.4370731721151 no 1920 0.431295365130246 2723 6467338 SGTC_2360 9040895 200 µM -0.178746578029118 0.43466832600523 no 1921 0.429068347062009 2781 4914414 SGTC_2449 5812982 45.77 µM -0.178845051110131 0.434626576465029 no 1922 0.429029684926271 2729 776185 SGTC_1831 st055328 12 µM -0.179564514450663 0.434321568413359 no 1923 0.428747232582271 2856 1103068 SGTC_3225 9130819 49.47 µM -0.180214165431049 0.434046190074614 no 1924 0.428492219045814 2774 4547121 SGTC_2408 sulbentine 18.36 µM -0.180339090577197 0.433993239645258 no 1925 0.428443184436468 2820 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_149 3970-0822 46.1 µM -0.180421417839467 0.433958345285366 no 1926 0.428410870608273 2726 3114250 YBL034C STU1 SGTC_2135 5326629 150.42 µM -0.180934793483841 0.433740762952741 no 1927 0.428209379149012 2775 5020077 SGTC_1418 3966-3099 2.4 µM -0.181136972020734 0.433655079786462 no 1928 0.428130032547039 2790 740335 SGTC_2671 danthron 100 µM -0.18227346488579 0.433173492792963 no 1929 0.427684060896216 2765 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_857 0438-0306 1.35 µM -0.182638999467219 0.433018619165672 no 1930 0.427540640921547 2818 4686136 SGTC_153 4077-0274 519.67 µM -0.182822291522609 0.432940963885084 no 1931 0.427468728642272 2950 3121976 SGTC_3255 9139072 49.47 µM -0.183760313382572 0.432543593093167 no 1932 0.427100745608147 2796 17646060 SGTC_350 k064-0020 19.8 µM -0.185029752158546 0.432005934054608 no 1933 0.426602849811734 2916 2790705 SGTC_21 0849-0113 22.993 µM -0.185178784532059 0.431942821012484 no 1934 0.426544404397708 2744 1560156 SGTC_990 3985-0011 41.3 µM -0.186290932124999 0.431471897637774 no 1935 0.426108309056602 2814 5399565 YGL099W LSG1 SGTC_121 0557-0495 61.343 µM -0.186446655616109 0.431405966456516 no 1936 0.426047253956074 2723 3104427 SGTC_2478 5763493 32.33 µM -0.186761502600574 0.431272670419723 no 1937 0.425923816119862 2721 1365576 YLR208W SEC13 SGTC_2864 9034755 47.6 µM -0.187935207381443 0.430775830845126 no 1938 0.42546372147741 2710 4930451 SGTC_728 3030-5151 22.5 µM -0.188041745532757 0.4307307377183 no 1939 0.425421963321556 2731 3125388 SGTC_697 0508-1955 564 µM -0.188340671866553 0.430604219574362 no 1940 0.425304802133138 2835 6243113 SGTC_1752 st044819 83.042 µM -0.188357260259266 0.430597198880297 no 1941 0.425298300671513 2787 441209 YML126C ERG13 SGTC_1975 st070967 30.8 µM -0.188660055318137 0.430469050992179 no 1942 0.42517963027068 2818 261391 SGTC_1272 0839-0021 27 µM -0.189937930050419 0.429928314035696 no 1943 0.424678884785469 2829 5027250 SGTC_1249 0481-0015 10.2 µM -0.190935414911986 0.429506316256704 no 1944 0.424288096737578 2733 4227577 SGTC_1266 0828-0227 32.9 µM -0.191307019448437 0.429349125123819 no 1945 0.424142530966965 2862 3913820 SGTC_115 0527-0192 112.043 µM -0.191407797625244 0.429306497230261 no 1946 0.424103055694208 2827 4233931 SGTC_689 0833-0039 98 µM -0.191944883650804 0.429079330553206 no 1947 0.423892689493762 2798 5374726 SGTC_2429 5902844 64.44 µM -0.191954915383017 0.429075087740555 no 1948 0.423888760464551 2904 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_44 0929-0055 61.211 µM -0.192740121851101 0.428743018618013 no 1949 0.423581249926125 2756 1379590 SGTC_3114 9122766 49.47 µM -0.195416798675911 0.427611414284988 no 1950 0.42253333333983 2801 17176985 SGTC_2790 5423970 71.43 µM -0.195739075763907 0.427475206889941 no 1951 0.422407198966322 2913 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2720 fluspirilene 36.88 µM -0.196246609256303 0.427260720140839 no 1952 0.422208574177248 2847 3396 An atypical antipsychotic. SGTC_958 1222-0007 33 µM -0.198029828192837 0.4265072918285 no 1953 0.421510863159578 2928 7312461 SGTC_3339 9145883 14.936 µM -0.198369294854867 0.426363893971725 no 1954 0.421378069608593 2896 2030670 SGTC_2485 5633444 17.78 µM -0.199068428749683 0.426068595800723 no 1955 0.421104608577324 2850 5724239 SGTC_2375 9072683 200 µM -0.201194625926927 0.425170794114855 no 1956 0.420273196733708 2826 16798029 SGTC_3191 9110352 49.47 µM -0.201640076755642 0.424982748370722 no 1957 0.42009905598868 2711 17122424 SGTC_509 pifithrin 175 µM -0.203599654248938 0.424155721805933 no 1958 0.419333181676654 2775 4817 A p53 inhibitor. SGTC_2191 5911152 200 µM -0.204782032799306 0.423656868119167 no 1959 0.418871212639376 2808 2875902 SGTC_2261 9010538 184.68 µM -0.205845083016573 0.423208464289413 no 1960 0.418455962031876 2899 6457250 SGTC_143 4032-1194 15.74 µM -0.20637935116959 0.42298314284863 no 1961 0.418247299513026 2709 1806963 SGTC_2103 5378138 10 µM -0.206634676021301 0.422875471424286 no 1962 0.41814758855773 2762 244142 SGTC_943 3253-1379 105 µM -0.207197523661319 0.422638136873769 no 1963 0.417927800592355 2929 668464 SGTC_1941 st076221 61.8 µM -0.209111099673945 0.421831454602795 no 1964 0.417180754982552 2944 2828568 SGTC_3314 9135860 59.4275 µM -0.209376799001855 0.421719472912792 no 1965 0.417077051544132 2809 25252478 SGTC_2612 dictamnine 15.46 µM -0.210055896843224 0.421433288990294 no 1966 0.416812023356545 2875 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1318 1280-3875 124 µM -0.210067986423949 0.421428194601219 no 1967 0.416807305557241 2840 373245 SGTC_582 0987-0078 156 µM -0.210742843929299 0.421143839475989 no 1968 0.416543970344254 2802 1625765 SGTC_1219 1469-0211 33.1 µM -0.212576475732009 0.420371436176939 no 1969 0.415828660857277 2884 6822282 SGTC_2256 7954252 200 µM -0.212612443149196 0.420356288234681 no 1970 0.415814632557315 2856 2972920 SGTC_1742 st038235 28.8875 µM -0.214141542474308 0.419712406192398 no 1971 0.415218340445239 2912 564103 YBR002C RER2 SGTC_2851 9015922 71.43 µM -0.215344295361544 0.419206094899595 no 1972 0.414749448461628 2980 2996893 SGTC_3221 9128209 49.47 µM -0.215909148259018 0.418968360326972 no 1973 0.414529283002342 2828 16460723 SGTC_1808 st050063 61.5 µM -0.215994648664609 0.418932377600412 no 1974 0.414495959431658 2916 4011993 SGTC_1157 4092-0394 27.6 µM -0.217240482326275 0.418408147321072 no 1975 0.414010468789501 2973 3659885 SGTC_743 1275-0778 158 µM -0.217614912016466 0.418250620548827 no 1976 0.413864582409194 2908 2849257 YMR203W TOM40 SGTC_2522 biochanin a 4.94 µM -0.217749894031561 0.418193835314509 no 1977 0.413811993239467 2917 5280373 A possible chelator. SGTC_189 3970-0742 2.116 µM -0.218789693111298 0.417756462178275 no 1978 0.413406938039753 2806 2891807 SGTC_2915 7971052 15.16 µM -0.218866150878912 0.417724305575333 no 1979 0.413377157439958 2784 5741558 SGTC_1178 0988-0033 191 µM -0.220018279283182 0.417239810208404 no 1980 0.412928459344518 2940 5392207 SGTC_767 0929-0023 86 µM -0.220554192437451 0.417014489691599 no 1981 0.412719785899738 2811 1204563 SGTC_502 l-744,832 89.3 µM -0.220943154120892 0.416850970842318 no 1982 0.412568347746668 2933 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2361 9034121 116 µM -0.221462990803569 0.416632454822729 no 1983 0.412365975107374 2833 6496917 SGTC_2049 5262831 67.185 µM -0.221678440302575 0.416541897065554 no 1984 0.412282107352402 2870 763417 SGTC_2955 9076254 12.21 µM -0.223589549677176 0.415738813794306 no 1985 0.411538347985361 2907 16459619 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.224388951853889 0.415402994466958 no 1986 0.411227333334956 2999 688798 SGTC_2698 st077697 67.5 µM -0.226389733541159 0.414562761278707 no 1987 0.410449156060525 2851 3154499 SGTC_3171 9103192 49.47 µM -0.227873414276416 0.413939938017135 no 1988 0.409872325673603 2847 13018434 SGTC_2699 st077704 54.6 µM -0.228250990936217 0.413781472410421 no 1989 0.409725561227009 2863 645852 SGTC_2079 5212404 121 µM -0.23003055634676 0.41303479387186 no 1990 0.409034012885535 2923 758462 SGTC_1161 k007-0610 110 µM -0.230484187254658 0.4128445074473 no 1991 0.408857774750718 2901 5843850 SGTC_928 2764-0428 58.7 µM -0.231546120654192 0.412399134025412 no 1992 0.408445279823037 2933 662578 SGTC_218 alverine citrate 93.75 µM -0.231653201255604 0.412354230816838 no 1993 0.408403691305851 2938 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_819 1013-0258 27.7 µM -0.231924039072293 0.412240662734669 no 1994 0.408298506520804 2835 5753198 SGTC_751 0833-0568 350 µM -0.232101436627323 0.412166280132549 no 1995 0.408229614538933 2891 6954252 SGTC_841 0251-0215 91.2 µM -0.232200376936189 0.412124795938945 no 1996 0.408191192502048 2876 3888614 SGTC_1604 st002052 72.4 µM -0.232702835345669 0.411914137797615 no 1997 0.407996083682563 2936 6254834 YHR062C RPP1 SGTC_489 paxilline 115 µM -0.234545904699494 0.411141639729154 no 1998 0.407280600032442 2873 105008 A toxic potassium channel blocker. SGTC_1453 4237-0541 195 µM -0.234888482234994 0.41099809077117 no 1999 0.407147644677489 2952 739892 SGTC_666 0272-0154 136 µM -0.235645911332234 0.410680750475629 no 2000 0.406853722200378 2861 6870312 SGTC_2943 9068529 45.32 µM -0.236537438927122 0.410307301806211 no 2001 0.406507829647457 2795 3270634 SGTC_1356 1502-0781 85.8 µM -0.237577925554283 0.409871559097673 no 2002 0.406104236606746 2820 567702 SGTC_1851 st056236 18.9 µM -0.237824779770116 0.409768195970685 no 2003 0.406008499262825 2942 5393171 SGTC_2858 9025781 8.96 µM -0.238074405134478 0.409663678881175 no 2004 0.405911692901194 2932 4894980 YPL153C RAD53 SGTC_3066 9117245 49.47 µM -0.238211673654186 0.409606207864716 no 2005 0.405858461715713 2871 17176980 SGTC_1465 k213-0056 144 µM -0.239608079495888 0.409021677024445 no 2006 0.405317050342368 2814 24048857 YMR208W ERG12 SGTC_776 4476-4378 112 µM -0.239778286052049 0.408950442929745 no 2007 0.405251070598063 2930 2892008 SGTC_2724 maprotiline 69.64 µM -0.240639338749356 0.408590125097772 no 2008 0.404917329008952 2869 4011 A tricyclic antidepressant. SGTC_1900 st060200 72.8 µM -0.241189183288033 0.408360076451389 no 2009 0.40470424698178 2808 688945 SGTC_1876 myriocin 605 nM -0.2422312839749 0.407924160181411 no 2010 0.404300477812386 2982 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_444 curcumin 90.4 µM -0.244221289946145 0.407092047078112 no 2011 0.403529719604016 2978 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3228 9131799 49.47 µM -0.244646017162709 0.40691450322942 no 2012 0.403365264982729 2897 17015818 SGTC_450 aminopyrene 156 nM -0.244817837270586 0.40684268467193 no 2013 0.403298740991524 2940 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2768 sulfasalazine 50.2 µM -0.246049173573867 0.406328094013139 no 2014 0.402822083641639 2933 5384001 An antioxidant and salicylic acid derivative. SGTC_1474 0330-0125 5.35 µM -0.24738248209798 0.405771070318586 no 2015 0.402306115103138 2878 X1474 SGTC_1753 st043925 64 µM -0.248188812298018 0.405434297759587 no 2016 0.401994161049193 2954 670181 SGTC_3204 9114183 49.47 µM -0.24874663806121 0.405201356721988 no 2017 0.401778385226534 2790 17027248 SGTC_771 0250-0039 27.3 µM -0.248909358109023 0.405133413194832 no 2018 0.401715448177473 2847 3005115 SGTC_225 nsc-122657 1.016 µM -0.249614974373037 0.404838817222994 no 2019 0.401442558612915 2970 275685 SGTC_1980 st071811 45.7 µM -0.250086607788431 0.404641939539926 no 2020 0.401260186209208 2998 4974850 SGTC_3189 9110682 49.47 µM -0.250402079426095 0.404510263178754 no 2021 0.401138210840486 2955 17122418 SGTC_1737 st035557 69.7 µM -0.250538818961826 0.404453192105712 no 2022 0.40108534424573 2775 5716916 SGTC_2464 5717415 7.67 µM -0.251063327212058 0.404234296605799 no 2023 0.400882574308068 2852 5285744 SGTC_2606 farnesol 9.78 µM -0.252192967347714 0.403762960457726 no 2024 0.400445956840406 3034 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_291 SEC14.278 35.5 µM -0.252364227044686 0.403691515468495 no 2025 0.400379774059593 2957 1068044 SGTC_2310 7668677 200 µM -0.254339962398091 0.402867524194162 no 2026 0.399616464539114 3071 2197143 SGTC_2215 7188065 200 µM -0.254711434955671 0.402712647574596 no 2027 0.399472991836995 2985 940217 SGTC_2930 9013230 14.89 µM -0.25497829603229 0.402601395637126 no 2028 0.399369931282625 2994 2995857 SGTC_1353 1498-1206 8.11 µM -0.255766000807076 0.402273054766064 no 2029 0.399065764145376 2869 6756808 SGTC_1966 st070145 16.1 µM -0.25584089062014 0.402241841850841 no 2030 0.399036849112192 2805 3748532 SGTC_2929 9013348 24.6 µM -0.256122609943599 0.402124431180568 no 2031 0.398928081957276 2963 2995952 SGTC_369 0957-0393 4.5 µM -0.257985111939431 0.401348428747471 no 2032 0.398209198675859 2917 6997992 SGTC_2828 7998861 71.43 µM -0.258684929295203 0.401056953597096 no 2033 0.3979391742727 2979 2988188 SGTC_2062 5245942 200 µM -0.259131361735378 0.400871042463132 no 2034 0.397766943922838 2838 1376160 SGTC_404 fumagillin 50 µM -0.26028948184938 0.40038886276353 no 2035 0.397320242666326 2915 12015870 A methionine aminopeptidase binder. SGTC_1646 st011709 75.6 µM -0.261137167941245 0.400036027461023 no 2036 0.396993364960524 2966 5757843 SGTC_2875 9039966 71.43 µM -0.261505441550426 0.399882765073527 no 2037 0.396851376865747 2952 6463691 SGTC_2239 6685329 187.64 µM -0.261713727096578 0.399796090857764 no 2038 0.396771078310079 2998 805680 SGTC_2424 5537928 59.2 µM -0.262299204399403 0.399552481656198 no 2039 0.396545387678138 2890 5382802 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.262479570688756 0.399477441551987 no 2040 0.396475866801257 2884 5106787 A p450 inhibitor. SGTC_3057 9095946 49.47 µM -0.263723030675486 0.398960210108679 no 2041 0.395996673846593 2832 24540043 SGTC_60 0986-0278 202 µM -0.26491640637058 0.398463978577216 no 2042 0.395536929648558 2868 3110598 SGTC_339 3091-4833 71.4 µM -0.265007083847457 0.398426279612624 no 2043 0.395502002371411 2874 3240077 SGTC_2926 9010726 65.15 µM -0.265374773466243 0.39827342316852 no 2044 0.395360383775129 2987 2994293 SGTC_1811 st050069 61.5 µM -0.265668603911743 0.398151282782867 no 2045 0.395247222562226 2878 3877702 SGTC_2138 5575593 77.673 µM -0.26578936741106 0.398101086315498 no 2046 0.395200716177868 2885 762213 SGTC_2887 9044784 58.44 µM -0.266336160916075 0.397873827645575 no 2047 0.394990163055392 2881 6465546 SGTC_1546 5-methoxyflavanone 78.7 µM -0.268400140550457 0.397016307934085 no 2048 0.394195665668115 2946 147795 SGTC_691 1548-0686 185 µM -0.26858701908954 0.396938690188697 no 2049 0.394123751309566 2895 46495133 SGTC_1790 st045711 43.5 µM -0.269134898598767 0.396711158587602 no 2050 0.393912937834793 3042 585119 SGTC_1284 0929-0043 16 µM -0.269574568020558 0.396528591518538 no 2051 0.393743783993633 2944 1239883 SGTC_1525 8-methoxypsoralen 92.5 µM -0.270038916681931 0.396335801341877 no 2052 0.393565157086171 3143 4114 Related to psoralen; DNA damaging agent. SGTC_660 4031-1742 102 µM -0.271071924286599 0.395907003994666 no 2053 0.39316785729443 2874 6738706 SGTC_1421 4029-0249 71.4 µM -0.271718782945808 0.395638559624341 no 2054 0.392919128892298 3044 2894095 SGTC_583 1488-1091 88.9 µM -0.272693402946543 0.395234188812077 no 2055 0.392544453135344 2961 4303273 SGTC_1302 1159-0335 255 µM -0.273118867638852 0.395057698426479 no 2056 0.392380921813035 2887 649284 SGTC_2977 9011197 71.43 µM -0.273427821944096 0.394929552129561 no 2057 0.392262184251896 3103 2704722 SGTC_2917 7979103 53.79 µM -0.273442857575776 0.394923316026282 no 2058 0.392256406001982 3039 2980565 SGTC_2418 pentamidine 31.67 µM -0.273948872868088 0.394713459365196 no 2059 0.392061956279307 2930 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1076 itraconazole 331 nM -0.274274494837561 0.394578432284848 no 2060 0.391936841698892 2867 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2871 9038510 12.99 µM -0.274328520340501 0.394556030518746 no 2061 0.391916084419071 3085 4945164 SGTC_1683 st010134 710 nM -0.27462987620632 0.394431079198892 no 2062 0.391800305339012 2876 3818134 SGTC_2036 5160441 105 µM -0.275085512226967 0.394242179258272 no 2063 0.391625270965761 2938 134534 YIL048W NEO1 SGTC_896 0964-0007 44.5 µM -0.275381635532073 0.394119424257686 no 2064 0.391511525790436 2970 6756758 SGTC_1725 st036284 20.55 µM -0.27584989796281 0.393925332146798 no 2065 0.391331678461015 3128 707914 SGTC_525 k781-2675 26.7 µM -0.277083012798239 0.393414339222408 no 2066 0.390858182590397 2900 3651118 YDL195W SEC31 SGTC_758 0868-0029 16 µM -0.27794054770609 0.393059091758272 no 2067 0.390528998568489 3003 762687 SGTC_1012 4112-3522 18 µM -0.278077019644322 0.393002564294069 no 2068 0.390476617981941 3062 3112398 SGTC_3086 9117350 49.47 µM -0.278079170415954 0.393001673450106 no 2069 0.390475792489828 2869 2679265 SGTC_2448 5185112 27.17 µM -0.278173776923728 0.392962488237473 no 2070 0.39043948185877 3036 5718189 SGTC_621 3584-0052 32.1 µM -0.279147406442766 0.39255928224002 no 2071 0.390065851699808 3000 2273927 SGTC_2896 9052656 71.43 µM -0.279953806587029 0.392225417661247 no 2072 0.389756472642666 3008 6469436 SGTC_910 3454-3003 490 µM -0.280200744732284 0.392123196553054 no 2073 0.389661747666482 3016 820824 SGTC_3351 9150312 21.596 µM -0.281924224030652 0.391409962546214 no 2074 0.389000807267893 2953 4904905 SGTC_821 1114-0266 29.2 µM -0.282901979079986 0.39100549653263 no 2075 0.388625988723203 2968 3123235 SGTC_2283 7944793 200 µM -0.283201979077248 0.390881419731654 no 2076 0.388511005674209 2986 2970533 SGTC_3007 9078383 71.4286 µM -0.283716709262798 0.390668558698497 no 2077 0.388313744282922 2942 6496995 SGTC_2528 xanthyletin 44.79 µM -0.28576127535089 0.389823374857555 no 2078 0.387530484810131 2894 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1565 sinapyl alcohol 95.1 µM -0.287587958907181 0.389068699675253 no 2079 0.386831081534215 3001 5280507 A phenol propionate derived from cinnamic acid. SGTC_299 1273-0059 1.44 µM -0.288409036477994 0.388729616175816 no 2080 0.38651682568454 3010 2848077 SGTC_2038 4100038 30.985 µM -0.28863686929508 0.38863554220977 no 2081 0.386429639069731 3011 3596803 SGTC_2247 cerulenin 830 nM -0.289625655665986 0.388227340267976 no 2082 0.386051318732725 3137 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2949 9072542 2.23 µM -0.290010705134351 0.3880684131737 no 2083 0.385904023937609 3020 16457352 SGTC_586 0957-0265 8.15 µM -0.291064318669587 0.38763363575103 no 2084 0.385501064301442 3007 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1818 st052136 56.3 µM -0.291158998366637 0.387594572722682 no 2085 0.385464859633742 3002 674169 SGTC_1247 0448-0043 5.84 µM -0.294058637927251 0.386398789819304 no 2086 0.384356548200175 3043 3089013 YGL099W LSG1 SGTC_638 3970-0837 4.09 µM -0.29536085243982 0.38586211943117 no 2087 0.38385911759951 2946 4118451 YLR208W SEC13 SGTC_2272 7805186 180 µM -0.295713955602974 0.385716635675654 no 2088 0.383724269285797 3063 2956062 YPR165W RHO1 SGTC_353 1988-1175 58.3 µM -0.296342870741072 0.385457553108973 no 2089 0.383484124654299 2845 2788357 SGTC_2987 9018338 71.43 µM -0.297650204577192 0.384919158557324 no 2090 0.382985076280343 2992 5055682 SGTC_585 0kpi-0023 191 µM -0.299900406787343 0.383992985918467 no 2091 0.382126562016237 3058 64601 SGTC_615 k087-0205 167 µM -0.300033944975424 0.383938042990708 no 2092 0.382075631676946 2949 9642773 SGTC_432 NS 1619 61.3 µM -0.300098356396965 0.383911542401053 no 2093 0.382051066433158 3111 4552 A K+/calcium channel activator. SGTC_812 4251-0442 148 µM -0.300486024321416 0.383752056869187 no 2094 0.381903227577176 3068 5723007 SGTC_637 1181-0519 7.26 µM -0.302802856361403 0.38279932977882 no 2095 0.38102005324676 2945 6252091 YGR060W ERG25 SGTC_501 nsc-95397 161 µM -0.302834113019429 0.382786481256208 no 2096 0.381008142460956 3098 262093 SGTC_1452 4194-0072 190 µM -0.304173098455043 0.382236192311207 no 2097 0.38049800937313 3095 1343545 SGTC_2112 5488546 200 µM -0.305844826547714 0.381549488448064 no 2098 0.379861398061188 2923 600757 SGTC_2092 5303694 80.6725 µM -0.306196112204411 0.381405236444588 no 2099 0.379727666177503 2966 1963699 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.306912435113105 0.381111136543684 no 2100 0.379455011864202 2929 364106 SGTC_2601 securinine 100 µM -0.307713601982553 0.380782283694063 no 2101 0.379150134366616 2921 442872 A GABA receptor antagonist. SGTC_2796 7949634 45.45 µM -0.307823012558699 0.380737380901078 no 2102 0.379108504895352 2910 2971588 SGTC_418 lividomycin a 100 µM -0.308150180945002 0.380603118510493 no 2103 0.378984029437343 3080 72394 An antibiotic. SGTC_2051 5263410 176 µM -0.308267274285725 0.380555069586412 no 2104 0.378939482805054 3018 227584 SGTC_2517 totarol 10 µM -0.308408893921386 0.380496958827903 no 2105 0.378885607612606 3036 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1995 st072814 61.1 µM -0.310516239656828 0.379632571314512 no 2106 0.378084205969366 2958 5769371 SGTC_710 3448-4187 58 µM -0.311586442132307 0.379193827366012 no 2107 0.37767741962535 2999 3946412 SGTC_1804 st050076 49.1 µM -0.312541812712628 0.378802291702269 no 2108 0.377314395704378 3082 3895976 SGTC_580 1123-0028 41 µM -0.31261978218795 0.378770343270165 no 2109 0.377284773462405 2943 1677248 YPR107C YTH1 SGTC_1050 3232-1156 69.3 µM -0.312943538164176 0.378637691297096 no 2110 0.37716177948972 3004 700529 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.313044117226415 0.378596484122929 no 2111 0.377123572326935 3083 521171 SGTC_1865 st057639 52.2 µM -0.313287975631137 0.378496581229639 no 2112 0.377030942358122 2918 688818 SGTC_1991 st073000 8.92 µM -0.313551415926786 0.378388665233669 no 2113 0.376930882131425 3151 4301969 YIL048W NEO1 SGTC_2157 5649910 96.377 µM -0.314619819004119 0.377951100640757 no 2114 0.376525164715278 2956 2858091 SGTC_1673 st016611 27.3 µM -0.315405901083744 0.377629260559449 no 2115 0.376226743457025 3161 5226799 SGTC_1611 st001856 99.4 µM -0.315931305900294 0.377414195090679 no 2116 0.376027324650743 2989 647478 SGTC_2153 5569715 200 µM -0.318029745159537 0.376555614559457 no 2117 0.375231186989238 2988 2054701 SGTC_2809 7964133 12.99 µM -0.318612258296364 0.37631738621209 no 2118 0.375010278384735 3002 1253665 SGTC_2417 cerulenin 830 nM -0.318760251837918 0.376256869315515 no 2119 0.374954160776472 3082 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.319040269326254 0.376142374066359 no 2120 0.374847988307747 3049 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_289 k017-0060 526 µM -0.319759952301889 0.375848155756712 no 2121 0.374575154175746 2980 5512909 SGTC_2556 citropten 84.59 µM -0.321494477210926 0.375139350117751 no 2122 0.373917848430345 3003 2775 A potential DNA crosslinker. SGTC_817 1391-0715 46 µM -0.322018285393054 0.374925381049712 no 2123 0.373719421003637 3012 1353946 SGTC_3140 9094243 49.47 µM -0.322374630902125 0.374779840377463 no 2124 0.373584450403964 3026 19291112 SGTC_3125 9127534 49.47 µM -0.322772719038868 0.374617272031962 no 2125 0.373433687564454 3047 1639235 SGTC_1501 4491-0275 38.4 µM -0.324673408348777 0.373841389957099 no 2126 0.372714131161514 3085 5104718 SGTC_2761 levamisole 97.89 µM -0.325704589777053 0.373420664049914 no 2127 0.37232393564954 3134 26879 An alkaline phosphatase inhibitor. SGTC_1852 st056254 31.4 µM -0.326074420752615 0.373269808343787 no 2128 0.372184024782571 2976 442583 SGTC_379 3970-0972 5.9 µM -0.326208153567621 0.373215262911969 no 2129 0.372133436433812 3031 2898042 YBL034C STU1 SGTC_761 k216-0224 480 µM -0.327534256189223 0.372674524809735 no 2130 0.371631918900429 3171 1340404 SGTC_1910 st062352 60.4 µM -0.329252985594205 0.37197406063058 no 2131 0.370982238369851 2924 2245730 SGTC_1415 3966-0071 78.1 µM -0.330916101005461 0.37129666492032 no 2132 0.370353929838704 3033 2893185 SGTC_992 3909-8734 162 µM -0.331246466340967 0.371162152744335 no 2133 0.370229162192902 3025 4288319 SGTC_2845 9003024 42.97 µM -0.333600945856499 0.370203955056227 no 2134 0.369340352209547 3213 2990173 SGTC_2916 7875993 68.79 µM -0.335675804946576 0.369360220879206 no 2135 0.368557676529606 3078 1299250 SGTC_2702 st077768 96.8 µM -0.339482807163623 0.367813754733021 no 2136 0.367123023401309 3082 6484119 SGTC_1864 st057645 30.4 µM -0.339837723625363 0.367669690593389 no 2137 0.366989368734923 3073 688666 SGTC_1681 tripelennamine 100 µM -0.341477353982268 0.367004390203697 no 2138 0.366372125176842 3069 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2318 6029776 164 µM -0.342559483620753 0.366565521201426 no 2139 0.365964943530943 3199 818325 SGTC_303 1348-1668 34.2 µM -0.344972727908628 0.365587433622106 no 2140 0.365057436799372 3048 5380509 SGTC_1499 4480-0877 67.3 µM -0.345696530765991 0.365294246375635 no 2141 0.364785395877427 3016 2861909 SGTC_1760 st045453 10.4495 µM -0.346490736399575 0.364972631990856 no 2142 0.364486972426501 3148 3323419 YIL048W NEO1 SGTC_2504 purpurogallin 52.29 µM -0.346864456452397 0.364821326518148 no 2143 0.36434657519412 2978 5281571 An antioxidant. SGTC_2697 mebhydrolin 72.4 µM -0.348027525662058 0.364350577460906 no 2144 0.363909755845723 3189 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1927 st060202 13.8 µM -0.350715325057262 0.363263481614858 no 2145 0.362900963622993 3112 688887 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.351041217032384 0.363131747373272 no 2146 0.362778713437685 3033 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1051 3253-3903 78 µM -0.351420676593698 0.362978380083696 no 2147 0.362636386341072 2970 5509239 SGTC_1160 4092-0570 10.5 µM -0.353013381233666 0.36233489187069 no 2148 0.362039204392755 3020 4994975 SGTC_2598 perillyl alcohol 100 µM -0.35373246524011 0.362044493165958 no 2149 0.361769694950674 3190 10819 An apoptosis inducer. SGTC_308 4092-1169 104 µM -0.353918893500263 0.361969217941113 no 2150 0.361699833663737 3032 2268590 YDL196W YDL196W SGTC_1426 4048-4480 71.7 µM -0.355104245559749 0.361490726441369 no 2151 0.361255748082141 3145 14224343 SGTC_829 1635-0120 117 µM -0.355475769345023 0.361340797835679 no 2152 0.361116597196285 3165 285054 SGTC_989 1501-0895 10.3 µM -0.357102180181242 0.360684709852009 no 2153 0.360507656198776 3153 2830112 SGTC_2543 pimpinellin 60.67 µM -0.357199470866329 0.360645476130271 no 2154 0.360471240995458 3025 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1193 1488-0126 41.5 µM -0.357292137937669 0.360608108304213 no 2155 0.360436557554192 3053 1384710 SGTC_2468 5987765 72.9 µM -0.359241423551597 0.359822371447887 no 2156 0.359707245266612 3079 26772094 SGTC_1187 1391-0724 117 µM -0.361596154653407 0.358873993470703 no 2157 0.358826919320577 3082 6997986 SGTC_1119 parthenolide 318.541 nM -0.36165604833258 0.358849882348847 no 2158 0.358804537574383 3230 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2798 7813637 45.45 µM -0.361740969605859 0.35881569694804 no 2159 0.3587728040653 3164 956368 SGTC_1856 st057054 55.7 µM -0.361804042253878 0.358790307531245 no 2160 0.358749235614226 3256 1266018 SGTC_2035 5154463 94.595 µM -0.362340866922494 0.358574238090781 no 2161 0.358548661311607 3199 2769623 SGTC_806 3966-4455 5.86 µM -0.364026614780582 0.357896026904452 no 2162 0.357919067589248 3057 714982 SGTC_588 3970-1144 52.9 µM -0.364258084194263 0.357802936934762 no 2163 0.357832648431711 3149 1888707 SGTC_1227 3909-8010 46.6 µM -0.365023102580433 0.357495329957316 no 2164 0.357547080502287 3049 15982272 SGTC_2290 7904846 200 µM -0.365446528117078 0.357325114155149 no 2165 0.357389057454365 3116 2962154 SGTC_1455 4262-0120 131 µM -0.365742584598491 0.357206117192242 no 2166 0.357278583252599 3210 1529587 SGTC_180 1486-1293 102.781 µM -0.366892309560621 0.356744128433646 no 2167 0.356849674065052 3209 4140536 SGTC_2506 ethyl hematommate 54.16 µM -0.366974679273021 0.356711038242039 no 2168 0.35681895267448 3119 3940691 An allergen. SGTC_3077 9117319 49.47 µM -0.367210514871182 0.356616302523819 no 2169 0.356730998325201 3060 17154678 SGTC_1603 st002045 67.8 µM -0.368234089682477 0.356205232666564 no 2170 0.356349346752407 3181 5887985 SGTC_1527 coumarin 137 µM -0.368774135575156 0.355988416357872 no 2171 0.356148042403167 3224 323 A hepatotoxic, DNA x-linker. SGTC_1391 3442-0225 151 µM -0.369988863518059 0.355500900598919 no 2172 0.355695394085631 3039 5227075 SGTC_173 1273-0061 2.693 µM -0.370494453217074 0.355298058144844 no 2173 0.355507054341101 3148 2847414 YPL266W DIM1 SGTC_3319 9138450 16.7555 µM -0.370710427179413 0.355211421939146 no 2174 0.355426611552073 3045 2029690 SGTC_1754 st042065 16.137 µM -0.371222303809813 0.355006116668502 no 2175 0.355235981037667 3138 1126236 YIL048W NEO1 SGTC_2589 lobaric acid 100 µM -0.371682253144188 0.354821674479946 no 2176 0.355064719918863 3064 73157 A novel microtubule depolymerizer. SGTC_321 4534-3890 65.3 µM -0.374075009668208 0.35386271583574 no 2177 0.354174255307119 3164 699746 SGTC_90 0870-0863 4.608 µM -0.374309441322974 0.353768811059209 no 2178 0.354087054320217 3016 1738164 SGTC_698 k064-0052 127 µM -0.37494094099493 0.353515899580689 no 2179 0.35385219496233 3146 5088751 SGTC_864 0469-0573 172 µM -0.375184523509407 0.353418363654046 no 2180 0.353761619694686 3071 689425 SGTC_768 0384-0033 77.3 µM -0.375387089698779 0.353337258918256 no 2181 0.353686302501249 3073 3965305 YMR134W ERG29 SGTC_1960 st011366 51.8 µM -0.376905942334391 0.352729343473235 no 2182 0.353121752606424 3040 3972846 SGTC_1898 st060199 18.6 µM -0.376934393981085 0.352717959382898 no 2183 0.353111180351608 3048 688866 SGTC_601 0986-0029 62.9 µM -0.377783621871676 0.352378226555127 no 2184 0.352795670753551 3091 24747981 SGTC_2675 theaflavin digallate 100 µM -0.378474570801294 0.352101899935738 no 2185 0.352539040446295 3133 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1622 st003707 19.4 µM -0.378643981839299 0.352034160416532 no 2186 0.352476128514371 3190 10140899 SGTC_1952 st077036 64.1 µM -0.379911131114567 0.351527635957654 no 2187 0.352005692164321 3084 2937007 SGTC_2945 9067681 61.76 µM -0.381659033533277 0.350829370014185 no 2188 0.351357145182129 3121 16456930 SGTC_2801 7907800 81.82 µM -0.382051194768426 0.350672775405637 no 2189 0.35121169583932 3164 6620925 SGTC_639 0833-0042 114 µM -0.382231517038912 0.350600779107866 no 2190 0.351144823120112 3097 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1495 4469-0029 237 µM -0.383203394735921 0.35021283520902 no 2191 0.350784480580457 3097 793680 SGTC_270 tamoxifen 5.46 µM -0.383658692741338 0.350031147865605 no 2192 0.350615716133396 3277 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3098 9119039 49.47 µM -0.384184302680468 0.349821445128849 no 2193 0.350420925954063 3103 17161528 SGTC_954 1189-0853 2.85 µM -0.384320607235479 0.349767071141111 no 2194 0.35037041813038 3106 2828194 SGTC_3346 9158254 43.5805 µM -0.384696226769351 0.349617246668051 no 2195 0.350231245535381 3161 17639500 SGTC_1922 5578187 25 µM -0.38711552980345 0.348652814229491 no 2196 0.349335340552892 3275 1350412 SGTC_1857 st056007 79.3 µM -0.389057204754739 0.347879490284014 no 2197 0.348616915007097 3168 619834 SGTC_2489 cantharidin 73.42 µM -0.390149497465061 0.347444733219565 no 2198 0.348213001723984 3091 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1885 st057546 99.9 µM -0.390437558216606 0.347330111967922 no 2199 0.348106509885774 3267 702008 SGTC_2873 9040596 71.43 µM -0.393337903693548 0.346176825077956 no 2200 0.347034963277476 3211 6463863 SGTC_3307 9126885 69.2785 µM -0.393376245022816 0.346161588638605 no 2201 0.347020806054092 3082 24824909 SGTC_1990 st072050 59.8 µM -0.393422856485776 0.346143066070835 no 2202 0.347003595438817 3078 17233948 SGTC_282 k297-0036 65.7 µM -0.393442775906894 0.346135150558815 no 2203 0.346996240574047 3217 5061378 SGTC_1912 st060209 90.8 µM -0.393687257638136 0.346038004714017 no 2204 0.346905975072862 3149 688787 SGTC_1129 3453-1384 223 µM -0.396165156064181 0.345053974063216 no 2205 0.345991597150777 3282 1084452 SGTC_2016 5121758 140 µM -0.396510315435535 0.344916986231431 no 2206 0.345864299771478 3095 2795203 SGTC_1959 st077091 55.8 µM -0.397173216614925 0.344653949145263 no 2207 0.345619865685364 3034 821356 YKL052C ASK1 SGTC_1588 farnesol 29.9 µM -0.3972029767679 0.344642142171136 no 2208 0.345608893618963 3093 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_145 3737-0113 38.366 µM -0.397858923262699 0.344381941925447 no 2209 0.345367090159211 3238 6849351 SGTC_2114 5491910 81.25 µM -0.399173367024411 0.343860751313497 no 2210 0.344882732931868 3222 2849228 SGTC_2588 indole-3-carbinol 100 µM -0.399833074804874 0.34359928203328 no 2211 0.344639734006762 3229 3712 Induces cell cycle arrest. SGTC_640 3381-0960 37.1 µM -0.400494554808861 0.343337185458674 no 2212 0.344396146641695 3179 1745025 SGTC_2357 9067248 200 µM -0.401086135762873 0.343102848611349 no 2213 0.344178353974917 3187 9150235 SGTC_652 0437-0092 114 µM -0.40207650427819 0.342710679238756 no 2214 0.343813861915706 3140 3091274 SGTC_625 k213-0058 121 µM -0.402518110565862 0.342535865132136 no 2215 0.343651381312225 3180 3655420 SGTC_1703 st026983 48.3 µM -0.403073872881201 0.342315909190696 no 2216 0.343446940222742 3254 1104023 SGTC_2123 5259487 200 µM -0.403417971300783 0.342179750989699 no 2217 0.343320384140765 3223 2173474 SGTC_1802 st050112 57.9 µM -0.405346659984338 0.341416957730989 no 2218 0.342611356564087 3145 4662563 SGTC_2467 5474540 200 µM -0.405856922838821 0.341215257759061 no 2219 0.342423865526445 3109 5413519 SGTC_3107 9121808 49.47 µM -0.406045452822111 0.341140745890937 no 2220 0.342354601869427 3207 662681 SGTC_2364 9055074 200 µM -0.406165151973589 0.341093440941526 no 2221 0.342310628587006 3198 6470630 SGTC_455 paf C-16 10 µM -0.408167475972655 0.340302495938763 no 2222 0.341575362168057 3109 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1663 st014140 55.4 µM -0.40821065129737 0.340285448822971 no 2223 0.341559514514389 3180 4207120 SGTC_978 1416-0512 87.4 µM -0.408343042273209 0.340233178308607 no 2224 0.34151092168594 3213 6814003 SGTC_3132 9126706 49.47 µM -0.412680597360626 0.33852233087941 no 2225 0.339920321081851 3304 850858 SGTC_265 mycophenolic acid 32.932 µM -0.412750532921131 0.338494773593116 no 2226 0.339894698638735 3361 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1623 st003709 20.3 µM -0.413236216794542 0.338303419431484 no 2227 0.339716777992926 3115 16192618 SGTC_1112 tnp00069 1.16933 µM -0.414429799158953 0.337833338442541 no 2228 0.339279684553441 3221 145826 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.414601687256671 0.337765662770321 no 2229 0.339216756410605 3115 688803 SGTC_1077 5-fluorocytosine 377 nM -0.414671280843722 0.337738263919139 no 2230 0.339191279510008 3187 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_348 k064-0012 10.7 µM -0.414777374039523 0.337696496902213 no 2231 0.339152442205309 3093 5066323 SGTC_427 1354-0053 47.3 µM -0.415436242793748 0.337437156682748 no 2232 0.338911289834844 3313 6813657 SGTC_1155 4088-0394 48.2 µM -0.417182424141925 0.336750208287112 no 2233 0.338272489955704 3117 2326248 SGTC_1480 1070-0044 41.2 µM -0.417656403228731 0.336563838565484 no 2234 0.338099175921485 3204 3124987 SGTC_2314 7727897 200 µM -0.420786018302448 0.33533427571343 no 2235 0.336955671117057 3125 900724 SGTC_2757 clomiphene 4.22 µM -0.421641577474224 0.334998449811079 no 2236 0.336643326797637 3345 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.422317024533567 0.33473341503655 no 2237 0.336396816697283 3263 5024745 SGTC_3193 9111931 49.47 µM -0.422901098760112 0.334504299875144 no 2238 0.336183710563852 3119 17087244 SGTC_1514 1189-1591 158 µM -0.423198129337812 0.334387807136456 no 2239 0.336075355759881 3312 767698 YMR146C TIF34 SGTC_1394 3474-0001 65.7 µM -0.423292014746483 0.334350989434159 no 2240 0.336041109811821 3187 5017666 YIL048W NEO1 SGTC_323 4013-0906 34.3 µM -0.425787921335641 0.333372790526783 no 2241 0.335131194559046 3232 2910086 SGTC_309 k408-0051 1.48 µM -0.426908329493268 0.332934046475059 no 2242 0.334723049198692 3216 3640463 SGTC_1926 methyl fluorone black 53.6 µM -0.427208106665125 0.332816694561136 no 2243 0.33461387862655 3152 72721 Reacts with homocysteine. SGTC_433 pimozide 108 µM -0.427552731337555 0.3326818067079 no 2244 0.334488393106942 3089 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3093 9117344 49.47 µM -0.428189864061333 0.332432486754117 no 2245 0.334256447585962 3278 24824913 SGTC_1563 conessine 56.1 µM -0.428897536713803 0.332155650312846 no 2246 0.333998896464668 3244 441082 An anti-amoebic, histamine inhibitor. SGTC_202 3594-0513 34.79 µM -0.43117093850262 0.331266932153062 no 2247 0.333172041633769 3193 708429 SGTC_863 0466-0191 129 µM -0.433706917949538 0.330276687464171 no 2248 0.332250641178494 3261 765160 YPR165W RHO1 SGTC_2751 anetholtrithion 17.25 µM -0.43410100991058 0.330122909579544 no 2249 0.332107546081625 3274 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2389 9091542 195.52 µM -0.434733305582234 0.329876242631944 no 2250 0.331878010182734 3201 3626624 YOL127W RPL25 SGTC_518 1021-0119 62.6 µM -0.436799870912319 0.329070564370688 no 2251 0.331128246317758 3172 1097762 SGTC_2511 berberine 10.47 µM -0.439625876302751 0.327970092869599 no 2252 0.330104048050404 3168 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1717 st033143 58.0435 µM -0.439653963603328 0.327959162898485 no 2253 0.330093875048137 3332 674616 SGTC_2210 7115885 190.385 µM -0.440130871667415 0.327773600050878 no 2254 0.329921161829346 3208 2927039 SGTC_1172 0370-0043 85 µM -0.440534631604323 0.327616532055677 no 2255 0.329774967686923 3291 376585 SGTC_1294 1000-1494 117 µM -0.440849063782379 0.327494234872318 no 2256 0.329661135511992 3206 712797 YDL207W GLE1 SGTC_496 calpeptin 138 µM -0.441576815992951 0.327211249467425 no 2257 0.329397731863688 3220 73364 A calpain inhibitor. SGTC_1037 k284-1091 78.7 µM -0.441594264734566 0.327204465767479 no 2258 0.329391417480327 3227 3334711 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.443907748168192 0.326305538796169 no 2259 0.328554641232628 3293 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1962 st076595 64.5 µM -0.44430636372122 0.326150754426345 no 2260 0.328410550476914 3178 279619 SGTC_1303 1160-0052 261 µM -0.44547934615003 0.325695453393807 no 2261 0.327986691218059 3253 3562476 SGTC_1158 4092-0494 91.8 µM -0.446717328760288 0.325215203977704 no 2262 0.327539584209457 3319 1148199 SGTC_920 mycophenolic acid 780.421 nM -0.447094582801254 0.325068913824695 no 2263 0.327403385106888 3185 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_830 4076-0286 57.8 µM -0.447702796756243 0.324833119688457 no 2264 0.327183851488358 3198 6866659 SGTC_1848 st056003 16.4 µM -0.44919366621816 0.324255432064599 no 2265 0.326645978073083 3305 146492 SGTC_1755 st041960 45.185 µM -0.449822370639961 0.324011946003995 no 2266 0.326419263020739 3298 2257073 SGTC_1958 st076513 41.9 µM -0.449830195180995 0.324008916172185 no 2267 0.326416441842239 3169 732122 YGL099W LSG1 SGTC_1880 MG-132 525 µM -0.450186729762588 0.323870870629044 no 2268 0.326287902002568 3305 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_619 1652-1634 108 µM -0.450199983587457 0.323865739387651 no 2269 0.326283124057185 3202 5400454 SGTC_1215 3852-0577 11.2 µM -0.451691700544553 0.323288432661851 no 2270 0.325745549010272 3340 2884876 SGTC_1688 st021091 57.6 µM -0.451781375471051 0.323253741265281 no 2271 0.325713244084463 3311 3656366 SGTC_1310 1188-0297 994 nM -0.451976846712569 0.323178127122467 no 2272 0.325642831122402 3210 1588352 SGTC_294 k038-0071 157 µM -0.452517213777694 0.322969134941829 no 2273 0.325448211611208 3250 24152826 SGTC_962 1254-0300 21.5 µM -0.452602733263124 0.322936064575332 no 2274 0.325417415129553 3190 7340576 SGTC_1046 2001-0062 216 µM -0.454894829358954 0.322050233778292 no 2275 0.324592451484902 3202 739778 SGTC_1666 st014829 29 µM -0.455290305410546 0.321897495418465 no 2276 0.324450199920241 3207 3858230 SGTC_1716 st033144 30.6155 µM -0.456124931718361 0.321575249882861 no 2277 0.324150071390277 3375 674617 SGTC_245 methotrexate 289.6 µM -0.457138215617918 0.321184205823374 no 2278 0.3237858517995 3268 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1196 1588-0294 184 µM -0.458519874242126 0.320651318884948 no 2279 0.323289493698135 3236 6144269 SGTC_593 1203-0218 61.7 µM -0.460557297991347 0.319866186463589 no 2280 0.322558127057042 3341 3666956 SGTC_3223 9129970 49.47 µM -0.464768121751987 0.318246080508845 no 2281 0.321048759403305 3193 17248386 SGTC_1839 st053978 48 µM -0.465770486336481 0.317860933016697 no 2282 0.32068989638768 3299 3788398 SGTC_2396 5342950 42.78 µM -0.466098023034384 0.317735123341533 no 2283 0.320572669156054 3272 1886677 SGTC_2868 9035608 32.47 µM -0.466605561720677 0.317540214914668 no 2284 0.320391053550085 3215 6462614 SGTC_791 1348-1292 225 µM -0.46781347773517 0.31707654633134 no 2285 0.319958990769436 3249 5437054 SGTC_1917 st066507 28.5 µM -0.468203208631309 0.316927006108128 no 2286 0.319819638916858 3181 3156428 SGTC_3341 9147222 25.867 µM -0.468397572836433 0.316852439496889 no 2287 0.319750151715489 3340 1939759 SGTC_735 3076-0345 636 µM -0.470261057578393 0.316137903173431 no 2288 0.319084258126179 3367 2888990 SGTC_1026 k007-1105 30.6 µM -0.470839892291471 0.315916093794014 no 2289 0.318877537231538 3305 7066794 SGTC_727 3032-0951 202 µM -0.472098183066383 0.315434145611606 no 2290 0.318428354652497 3262 3652836 SGTC_244 nsc-207895 1.295 µM -0.472662035138057 0.315218281815283 no 2291 0.318227158180031 3212 42640 SGTC_499 genistein 192 µM -0.473049023421339 0.315070164629261 no 2292 0.318089102138195 3322 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1033 k072-0102 21.3 µM -0.473146475552239 0.315032870160828 no 2293 0.318054340583759 3348 5965931 SGTC_981 1488-1094 54.9 µM -0.473619719287713 0.314851788844506 no 2294 0.317885555496295 3260 3449522 SGTC_409 arachidonic acid 100 µM -0.474162255457343 0.314644248324796 no 2295 0.317692103407506 3239 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_129 0088-0017 176.636 µM -0.474208983876255 0.314626375682047 no 2296 0.31767544378484 3338 182446 SGTC_1656 st012921 11 µM -0.474274892211043 0.314601167861017 no 2297 0.317651946763337 3300 6732821 SGTC_1443 4112-3303 14 µM -0.474754464131095 0.314417773031907 no 2298 0.317480996399873 3254 704433 SGTC_1803 st050068 52.4 µM -0.477433998770825 0.313393926233597 no 2299 0.316526554479238 3374 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.47746417551582 0.313382403902425 no 2300 0.316515812554923 3350 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1630 st005209 31.3 µM -0.477815654521382 0.313248212736385 no 2301 0.316390709041756 3366 3367314 SGTC_3025 9087895 49.47 µM -0.478790431928838 0.312876181891252 no 2302 0.316043862069486 3348 17173641 SGTC_2979 9012552 45.46 µM -0.479186437529919 0.312725097881951 no 2303 0.315903000890844 3340 17100905 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.48102643780619 0.312023514181378 no 2304 0.315248854436136 3325 165521 SGTC_3050 9093513 49.47 µM -0.481145921365024 0.311977979178408 no 2305 0.315206396311429 3304 25236664 SGTC_1704 st028805 70.8 µM -0.481432504077811 0.311868774652682 no 2306 0.315104569951771 3306 2876101 SGTC_529 4076-0302 30.3 µM -0.481814741367173 0.311723145960783 no 2307 0.314968778210589 3248 5816522 SGTC_1055 3448-0672 86 µM -0.481911530145987 0.311686275046833 no 2308 0.314934397471688 3365 748378 SGTC_1913 st060213 96.1 µM -0.482700512527937 0.311385788937191 no 2309 0.314654199641861 3402 688959 SGTC_2664 lyso-paf C-16 73.48 µM -0.485311257944888 0.310392375733336 no 2310 0.313727785417862 3247 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3220 9131269 49.47 µM -0.485440903879596 0.310343080184464 no 2311 0.313681811526701 3356 17722206 SGTC_1425 4048-4433 7.33 µM -0.486705092585198 0.3098625737197 no 2312 0.31323366789294 3367 23734946 SGTC_1224 0823-0416 294 µM -0.486920414851291 0.30978076404713 no 2313 0.313157365526353 3380 3598164 SGTC_1253 0550-0034 176 µM -0.487022049376847 0.309742152236212 no 2314 0.313121352732077 3343 5969915 SGTC_305 1682-2595 20.8 µM -0.489646785917665 0.308745720864256 no 2315 0.312191931741896 3326 226033 SGTC_451 chloral hydrate 100 µM -0.490003698767774 0.308610334140723 no 2316 0.312065640748782 3346 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_155 k072-0202 43.6 µM -0.49008090711956 0.308581050340733 no 2317 0.312038324045083 3341 5857737 SGTC_2666 tannic acid 100 µM -0.490188352023701 0.308540300362454 no 2318 0.312000311216941 3380 16134267 A thiamine antagonist. SGTC_1928 4'-methoxychalcone 40.3 µM -0.490389179637694 0.308464140012522 no 2319 0.311929265979101 3431 641818 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.491122885511155 0.30818596500243 no 2320 0.311669767993759 3343 616764 SGTC_633 0437-0093 97.7 µM -0.49190562137474 0.30788932232648 no 2321 0.311393032095117 3298 2831118 SGTC_1712 st032288 53.4 µM -0.492239214347123 0.307762934779263 no 2322 0.311275122824536 3365 2883011 SGTC_3167 9103034 49.47 µM -0.492427486300581 0.307691614715536 no 2323 0.311208586177423 3352 5127859 SGTC_595 3909-8003 73.7 µM -0.493264438293739 0.30737465351353 no 2324 0.310912876076268 3368 699517 SGTC_2006 4011487 200 µM -0.493577163697757 0.307256258499205 no 2325 0.310802415915235 3409 45595294 SGTC_1 0258-0098 57.368 µM -0.494322154108852 0.306974292793613 no 2326 0.310539340783381 3271 6790032 YDR047W HEM12 SGTC_3295 9122362 53.5725 µM -0.494942817073685 0.306739469968551 no 2327 0.310320242806753 3344 4730473 SGTC_2552 juarezic acid 87.02 µM -0.494992488544064 0.306720680594135 no 2328 0.310302711369045 3308 1549512 SGTC_553 k007-0256 45.7 µM -0.495063257765173 0.306693911388246 no 2329 0.310277734270543 3306 6287000 SGTC_17 0960-0276 49.807 µM -0.496400258214905 0.306188370706866 no 2330 0.309806021465665 3289 6821114 SGTC_695 3505-6186 243 µM -0.498799112741937 0.305282251410243 no 2331 0.308960456345658 3358 1819379 SGTC_1788 fluconazole 20 µM -0.498819811346683 0.305274438105554 no 2332 0.30895316475061 3357 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_877 0771-0151 33.1 µM -0.499085248694223 0.305174248740391 no 2333 0.308859664559085 3312 6166523 SGTC_235 0330-0087 5 mM -0.500963624428737 0.304465673037396 no 2334 0.308198361745471 3340 46494818 YHR062C RPP1 SGTC_2521 angolensin 13.4 µM -0.501050641376105 0.304432865569912 no 2335 0.3081677415342 3387 821428 A flavenoid. SGTC_1626 st003712 1.76 µM -0.503187477421876 0.303627721631849 no 2336 0.307416234116027 3392 24207035 SGTC_1329 1447-1697 50.6 µM -0.506066288362061 0.302544512925864 no 2337 0.306405057716716 3364 2840515 SGTC_1165 k072-0275 30.3 µM -0.509044004933229 0.301425915219203 no 2338 0.305360689803592 3419 6153523 YGL055W OLE1 SGTC_2957 9076800 11.52 µM -0.509198495059709 0.301367930871356 no 2339 0.305306548929424 3295 16459615 SGTC_635 k038-0028 24.7 µM -0.509276648221011 0.301338599776375 no 2340 0.305279161872625 3321 4035102 SGTC_678 1218-2179 85.9 µM -0.510015149000119 0.301061501897371 no 2341 0.305020424346308 3344 6820081 YOR116C RPO31 SGTC_1545 lovastatin 49.4 µM -0.511397545976544 0.300543112315215 no 2342 0.304536356472459 3365 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_584 0986-0246 15.4 µM -0.511627236262273 0.300457019064732 no 2343 0.304455959958244 3427 53315 YDR232W HEM1 SGTC_2071 5230951 39.92 µM -0.513160155462942 0.299882730865487 no 2344 0.303919647510774 3428 1799272 SGTC_260 nsc-65238 3.989 µM -0.513438207233718 0.299778615654102 no 2345 0.30382241250758 3360 3246252 SGTC_2661 dactinomycin 12.96 µM -0.51362702688633 0.299707922333941 no 2346 0.303756389985212 3323 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1841 st054148 70 µM -0.514750878526356 0.299287313107207 no 2347 0.303363557483225 3346 675442 SGTC_1827 berberine 7.24 µM -0.515387456038112 0.299049188441598 no 2348 0.30314114815176 3255 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_125 0133-0007 11.75 µM -0.517338967672547 0.298319722794348 no 2349 0.302459778193812 3448 26541 SGTC_468 gf-109203x 121 µM -0.517563577830313 0.298235816606764 no 2350 0.30238139968067 3335 2396 A protein kinase C inhibitor. SGTC_1363 1636-0063 10.4 µM -0.518815436650884 0.297768364668503 no 2351 0.301944726074888 3345 6072185 SGTC_1295 1013-0063 9.78 µM -0.519038264692483 0.297685194331267 no 2352 0.30186702886972 3436 6826038 SGTC_3356 9151811 4.48 µM -0.519921720658925 0.297355549673671 no 2353 0.301559067866429 3285 1859254 YPR165W RHO1 SGTC_3037 9091026 49.47 µM -0.521614508496835 0.296724384695447 no 2354 0.3009693797846 3405 25236398 YIL048W NEO1 SGTC_720 r052-1644 49.9 µM -0.524866357787805 0.295513639615474 no 2355 0.299838048894537 3396 1422863 YOR257W CDC31 SGTC_1953 st076800 12.1 µM -0.525327582491439 0.295342098211167 no 2356 0.299677743069527 3325 297591 SGTC_1150 3909-7983 10.9 µM -0.526404857040797 0.294941610524531 no 2357 0.299303470863449 3324 23965914 SGTC_2561 acetosyringone 100 µM -0.526592544428438 0.294871861448797 no 2358 0.299238285251309 3272 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1281 0884-0031 11.8 µM -0.527343428070539 0.294592891393283 no 2359 0.298977560691665 3367 1548255 SGTC_3148 9097893 49.47 µM -0.52810001901333 0.294311924168597 no 2360 0.298714958821904 3276 17174100 SGTC_1691 st019933 84.6 µM -0.529345647698026 0.293849617934234 no 2361 0.298282847540016 3388 6176082 SGTC_1064 honokiol 6.76 µM -0.530108062609857 0.293566818887169 no 2362 0.298018504648987 3370 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2690 usnic acid 100 µM -0.530280508907133 0.293502871657394 no 2363 0.297958729240717 3521 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_789 1309-1135 70.6 µM -0.531496400316238 0.293052173129653 no 2364 0.297537417555897 3421 3092424 SGTC_549 1661-1316 519 µM -0.531560062335376 0.293028584163713 no 2365 0.297515365882827 3464 2857282 SGTC_2691 st077356 60.2 µM -0.53271159918011 0.292602052342216 no 2366 0.297116617789719 3464 2839272 SGTC_392 N-ethylmaleimide 8.33 µM -0.532754488762038 0.292586171518616 no 2367 0.297101770933066 3321 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3102 9121669 49.47 µM -0.533715138153827 0.292230574659724 no 2368 0.296769317013843 3345 41905072 SGTC_2289 7946404 165.07 µM -0.534220331830644 0.292043651356907 no 2369 0.296594551953017 3336 1246120 YPR165W RHO1 SGTC_2095 5432005 200 µM -0.534595602198494 0.291904836139472 no 2370 0.296464762665248 3326 783734 SGTC_855 0428-0020 25 µM -0.534785348975791 0.291834659136495 no 2371 0.296399147624749 3377 6812414 SGTC_1221 2958-7315 257 µM -0.536091166528483 0.291351921611139 no 2372 0.295947772411092 3416 4562705 SGTC_171 k064-0041 9.68 µM -0.536151229749503 0.291329726273176 no 2373 0.295927018261888 3327 53325 SGTC_828 2074-0507 139 µM -0.536174220643866 0.291321230589485 no 2374 0.29591907420194 3444 X828 SGTC_2951 9072950 58.06 µM -0.53685385510143 0.291070141694987 no 2375 0.295684283875514 3448 16488155 SGTC_3355 9151058 44.0485 µM -0.537843897895309 0.290704554369895 no 2376 0.295342411430894 3431 17015728 SGTC_2659 sanguinarine 24.21 µM -0.537941135868846 0.290668659455814 no 2377 0.295308843922196 3334 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2132 5317594 122.667 µM -0.53830783519794 0.290533312877203 no 2378 0.295182271490441 3330 794577 SGTC_3267 9137951 49.47 µM -0.539487394024812 0.290098144747454 no 2379 0.29477529644174 3345 16643986 SGTC_1850 st056238 17 µM -0.54071867966922 0.289644219464579 no 2380 0.294350750630227 3421 5393177 SGTC_537 1334-0398 209 µM -0.541058196416537 0.289519112020278 no 2381 0.294233735342882 3453 5846986 SGTC_526 4469-0568 170 µM -0.541376797615786 0.28940173476452 no 2382 0.294123948198964 3398 2901964 SGTC_6 0844-0013 19.835 µM -0.541954782259054 0.289188854009585 no 2383 0.29392482816223 3495 1584900 SGTC_116 0155-0182 31.788 µM -0.542415819028312 0.289019099780672 no 2384 0.293766042253324 3347 771486 SGTC_1326 1431-2094 10.8 µM -0.542597570907022 0.288952191429974 no 2385 0.293703455905909 3337 616278 SGTC_2430 5571206 200 µM -0.542722463078599 0.28890621907823 no 2386 0.293660452803722 3483 1731771 SGTC_3244 9134489 49.47 µM -0.542877964060538 0.288848984546523 no 2387 0.293606914493505 3409 16584271 SGTC_3156 9099931 49.47 µM -0.542886009255795 0.28884602353369 no 2388 0.2936041446908 3327 18111053 SGTC_2150 5556613 200 µM -0.542983065856784 0.288810303234314 no 2389 0.293570730962778 3364 743190 SGTC_546 peri-Naphthalide 147 µM -0.543064319410269 0.288780400620699 no 2390 0.293542759112517 3336 223824 A penicillin ester. SGTC_2131 toluylene red 5.2905 µM -0.545547265197142 0.287867340270064 no 2391 0.292688591160305 3361 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3275 9138069 49.47 µM -0.546043702578416 0.287684947690622 no 2392 0.292517948364253 3420 17617007 SGTC_1613 st002381 52.1 µM -0.54613041581016 0.2876530945932 no 2393 0.292488146754343 3438 551167 SGTC_3304 9125678 46.087 µM -0.547477358621841 0.287158524977924 no 2394 0.292025410666131 3368 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2055 5235184 200 µM -0.547563098498445 0.287127056696442 no 2395 0.291995966662185 3455 2836034 SGTC_3328 9140624 29.0385 µM -0.54878049411745 0.286680423968468 no 2396 0.291578049021244 3455 4904392 SGTC_2058 5236698 133 µM -0.550228209233253 0.286149721847527 no 2397 0.291081428746208 3359 766665 SGTC_2 0422-0095 29 µM -0.550372640999663 0.286096801790972 no 2398 0.291031904945396 3360 6790840 SGTC_1367 1812-0510 76.9 µM -0.55092184192314 0.285895616062128 no 2399 0.290843626940282 3395 1142582 YDR527W RBA50 SGTC_667 1498-1044 59 µM -0.551030300691835 0.28585589291742 no 2400 0.290806451652276 3390 6739982 SGTC_1629 st005085 44.9 µM -0.55122517827758 0.285784525379567 no 2401 0.290739661064497 3343 24207091 SGTC_2734 clemastine 41.6 µM -0.551399256811301 0.285720781980551 no 2402 0.290680005022995 3368 26987 Clemastine is a selective histamine H1 antagonist. SGTC_587 k089-0003 57 µM -0.551691531778455 0.285613773085822 no 2403 0.290579856398172 3426 9659696 SGTC_194 1486-1323 56.904 µM -0.553230621078229 0.285050590353577 no 2404 0.290052750784224 3408 5178754 SGTC_3165 9101544 49.47 µM -0.553369028500813 0.28499997034271 no 2405 0.290005371135186 3444 5002184 SGTC_3149 9097855 49.47 µM -0.553476488995427 0.284960671567203 no 2406 0.289968587745371 3437 25236625 YMR079W SEC14 SGTC_2144 5628481 200 µM -0.55382083968846 0.284834758417039 no 2407 0.289850732323345 3391 2818399 SGTC_393 acivicin 6.25 µM -0.555580681939723 0.284191680194849 no 2408 0.289248770296803 3344 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_993 3909-8757 62.7 µM -0.556756852307851 0.283762273642707 no 2409 0.28884678377225 3342 4288324 YLR208W SEC13 SGTC_1757 st041620 31.8375 µM -0.557445755621735 0.283510907163811 no 2410 0.288611455497146 3426 5289815 SGTC_2682 pyrogallin 40.03 µM -0.558548522804676 0.283108752644197 no 2411 0.288234940097325 3421 822798 An ATP competetive kinase inhibitor. SGTC_35 0133-0054 64.071 µM -0.558590277416132 0.283093531051821 no 2412 0.288220688464582 3392 99677 SGTC_1014 4130-3005 69.3 µM -0.56001425717786 0.282574656211641 no 2413 0.287734856517971 3382 743608 SGTC_1689 st020265 53.493 µM -0.561342912387737 0.282090928750596 no 2414 0.287281896542169 3476 5758320 YPR016C TIF6 SGTC_510 ag-490 170 µM -0.56136525997489 0.282082796008628 no 2415 0.287274280775808 3537 5328779 SGTC_2557 derrustone 83.84 µM -0.561451482353331 0.282051418987737 no 2416 0.287244898208739 3478 629853 An antioxidant. SGTC_688 0527-0193 473 µM -0.561769624723453 0.2819356589501 no 2417 0.287136495048252 3379 4007154 SGTC_1733 st037357 54.9 µM -0.5663948969557 0.280255286766548 no 2418 0.285562681491977 3400 1272339 YGL099W LSG1 SGTC_73 0327-0325 16.231 µM -0.566763842426919 0.280121457221848 no 2419 0.285437319657638 3488 53298 SGTC_2338 7999974 200 µM -0.568420098570202 0.279521056531958 no 2420 0.284874873131053 3498 315925 SGTC_515 4092-1064 102 µM -0.56848022242352 0.279499273109069 no 2421 0.284854465674919 3541 717353 SGTC_2658 polymyxin b sulfate 77.05 µM -0.568764394001176 0.279396326300192 no 2422 0.28475802056839 3443 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1019 4262-0212 3.4 µM -0.568871489645901 0.27935753355107 no 2423 0.284721677377992 3498 4677213 SGTC_3224 9130643 49.47 µM -0.56908474028566 0.279280296573514 no 2424 0.284649316803181 3537 17644395 SGTC_428 3448-4153 16.5 µM -0.569369431328078 0.279177200864088 no 2425 0.284552728634387 3344 3834874 SGTC_258 haloperidol 50.781 µM -0.569812134746005 0.279016920592683 no 2426 0.284402562132425 3421 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2818 7996756 12.99 µM -0.570567019713053 0.278743718608159 no 2427 0.284146589956726 3413 2241621 SGTC_3175 9106517 49.47 µM -0.573065007298364 0.277840596260788 no 2428 0.283300339608279 3446 41468073 SGTC_2202 7226349 200 µM -0.573155913994061 0.277807756815435 no 2429 0.283269565696065 3401 844334 SGTC_1390 3413-2614 145 µM -0.57329727359487 0.277756695355276 no 2430 0.283221715553065 3463 3421432 SGTC_3181 9108277 49.47 µM -0.57431170692509 0.27739039952788 no 2431 0.282878444258175 3393 17097298 SGTC_201 4262-0159 12.803 µM -0.574328523445593 0.277384329338909 no 2432 0.282872755446192 3426 1341029 SGTC_210 3551-0445 56.827 µM -0.574682252150918 0.277256660422687 no 2433 0.282753106322167 3526 2865180 YOR207C RET1 SGTC_2323 6148992 148.28 µM -0.575092638801239 0.277108578360886 no 2434 0.28261432306163 3389 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_755 1995-0008 37.3 µM -0.575429742733676 0.276986968263711 no 2435 0.282500346818568 3494 689533 SGTC_891 0929-0073 133 µM -0.575794265740574 0.27685549615467 no 2436 0.28237712494976 3486 5603632 SGTC_2723 salbutamol 83.58 µM -0.578231713808917 0.275977170708356 no 2437 0.281553845079587 3471 9884233 β2-adrenoceptor agonist SGTC_2988 9073640 71.4286 µM -0.578890585569381 0.275739983870535 no 2438 0.281331501493351 3547 9102229 SGTC_921 1561-0023 372 µM -0.579089989418522 0.275668220356735 no 2439 0.281264227162496 3483 24050882 SGTC_380 3970-0968 6 µM -0.579290559929669 0.275596046236316 no 2440 0.281196567062586 3432 2891601 SGTC_2332 7982454 138.89 µM -0.580052183225894 0.275322065227895 no 2441 0.280939714027664 3481 2981748 SGTC_996 3970-0799 1.8 µM -0.582455074508657 0.274458545626128 no 2442 0.280130096936143 3538 6615648 YGL040C HEM2 SGTC_1094 duloxetine 25.4 µM -0.583165910239648 0.274203351207479 no 2443 0.2798908087126 3473 60834 A selective serotonin reuptake inhibitor. SGTC_2457 5731572 11.68 µM -0.584311609001513 0.27379228509484 no 2444 0.279505341567282 3516 2865357 SGTC_2475 5812728 15.03 µM -0.585787191785004 0.273263309052688 no 2445 0.279009265981966 3502 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1729 st035615 45.989 µM -0.585972094685186 0.27319705962852 no 2446 0.278947133754751 3437 17385451 SGTC_982 1491-0518 27.5 µM -0.586364133567232 0.273056621149829 no 2447 0.27881542066989 3422 3091256 SGTC_2635 hydroquinidine 100 µM -0.586394165694596 0.273045864339998 no 2448 0.278805332041032 3475 442912 An experimental heart treatment. SGTC_1614 st002383 48.6 µM -0.587319544335161 0.272714518213623 no 2449 0.278494558664363 3503 1947235 SGTC_805 3852-0218 479 µM -0.587466176893116 0.272662032478294 no 2450 0.278445329996613 3436 6615355 SGTC_3070 9117005 49.47 µM -0.590123354600943 0.27171179032862 no 2451 0.277553976167793 3529 8779016 SGTC_2432 5630864 12.22 µM -0.590258974058805 0.271663335253523 no 2452 0.277508519863431 3485 5714970 SGTC_1834 st055981 52.8 µM -0.591550257171699 0.271202192118028 no 2453 0.277075895879488 3552 471719 YDL150W RPC53 SGTC_2838 9002687 71.43 µM -0.592154221185326 0.27098663847255 no 2454 0.276873660647134 3452 6457060 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.593560682194453 0.270485006627851 no 2455 0.276402992469354 3484 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3318 9139014 38.6185 µM -0.594477090028408 0.270158408189503 no 2456 0.276096530482372 3500 16643984 SGTC_2995 9067767 71.4286 µM -0.594917077399986 0.270001671276343 no 2457 0.275949450700051 3437 11673567 SGTC_1813 st051246 8.6015 µM -0.595281632425735 0.269871840143983 no 2458 0.275827615739754 3470 5291959 SGTC_2676 harmalol 100 µM -0.596083261427562 0.269586461241433 no 2459 0.275559802848335 3534 5459187 A monoamine oxidase inhibitor SGTC_12 0849-0099 9.267 µM -0.596199741043664 0.269545007231716 no 2460 0.275520899302062 3467 6071388 SGTC_2502 avocadyne acetate 18.59 µM -0.597899246607066 0.268940532589589 no 2461 0.274953581307781 3496 3952079 SGTC_2378 9074213 121.43 µM -0.598205615442255 0.268831636758283 no 2462 0.274851372502744 3517 657714 SGTC_1191 1487-1166 10.6 µM -0.599283071923936 0.268448841265959 no 2463 0.27449206719224 3534 3955771 SGTC_3028 9087778 49.47 µM -0.599413257998708 0.268402607714157 no 2464 0.274448669028659 3431 17217395 SGTC_3321 9137793 26.8275 µM -0.600721941898311 0.267938071612262 no 2465 0.274012601064076 3519 4904192 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.600844962149957 0.267894424639257 no 2466 0.273971626967441 3524 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3201 9113999 49.47 µM -0.601644603862962 0.267610803057236 no 2467 0.27370536582283 3516 16649224 SGTC_2892 9047358 58.44 µM -0.601646008486671 0.267610304990322 no 2468 0.273704898230114 3456 6466771 SGTC_399 oxolinic acid 75 µM -0.602157736042356 0.267428882109989 no 2469 0.273534572801427 3452 4628 A DNA gyrase inhibitor. SGTC_191 3914-0123 66.505 µM -0.60736169313014 0.265587452239891 no 2470 0.271805452281056 3406 3144412 SGTC_1070 indatraline 8.81 µM -0.608210306644879 0.26528777977892 no 2471 0.271523999865164 3514 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2228 7354201 200 µM -0.60842961936204 0.265210361395616 no 2472 0.271451285895547 3550 753451 SGTC_307 1501-1223 22.3 µM -0.609108542335158 0.264970771256653 no 2473 0.271226247904448 3520 2830329 SGTC_1114 scopoletin 1.73284 µM -0.609676156842898 0.264770546031766 no 2474 0.271038175984001 3549 5280460 A coumarin with genotoxic properties. SGTC_3036 9090181 49.47 µM -0.610466503355127 0.264491880589824 no 2475 0.270776413011567 3540 25236586 SGTC_459 nigericin 15.3 µM -0.610842130477273 0.264359491911201 no 2476 0.270652049469066 3575 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3227 9130768 49.47 µM -0.611720768851754 0.264049950186468 no 2477 0.27036125918073 3538 17720899 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.611987106184212 0.263956156813289 no 2478 0.270273144203862 3503 6708561 SGTC_438 sphingosine 6.67 µM -0.613879896636049 0.263290081108314 no 2479 0.269647347800615 3376 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1317 1273-0028 910 nM -0.614060736229325 0.263226488345467 no 2480 0.269587596431503 3506 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_66 0109-0187 42.4 µM -0.614887470816147 0.262935864704891 no 2481 0.269314518847386 3565 759417 SGTC_83 0170-0301 39.027 µM -0.615209656152746 0.262822650694955 no 2482 0.269208135819073 3490 3089716 SGTC_1789 tunicamycin 25 nM -0.615234719180746 0.262813844741262 no 2483 0.269199861090923 3551 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_836 0330-0104 1.35 µM -0.615369152753965 0.26276661376534 no 2484 0.269155479115514 3544 46494820 SGTC_1324 1418-0026 34.4 µM -0.615586994383432 0.262690087989822 no 2485 0.269083568552645 3558 1372513 SGTC_91 0417-1751 58.384 µM -0.616168312390464 0.262485932107038 no 2486 0.26889171990503 3604 6795624 SGTC_764 1951-2361 146 µM -0.617334289295881 0.262076692017082 no 2487 0.268507127183503 3462 5438930 SGTC_2486 5283202 22.39 µM -0.618015641944908 0.26183769911719 no 2488 0.26828251387712 3479 1377751 SGTC_1364 1653-0028 37.6 µM -0.618339269339286 0.261724221960446 no 2489 0.268175860659173 3507 5718652 SGTC_860 0443-0016 25.1 µM -0.618660522212258 0.261611602370156 no 2490 0.268070011084129 3552 5337942 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.61894476868594 0.261511976622844 no 2491 0.267976372283467 3513 6708784 An antioxidant flavonoid SGTC_3286 9117135 37.221 µM -0.619148986615323 0.261440412162348 no 2492 0.267909107309677 3462 3438150 SGTC_1785 bathophenanthroline 24 µM -0.619169340912169 0.26143327992023 no 2493 0.267902403510087 3485 72812 An iron chelator. SGTC_2137 5261020 140 µM -0.619708476162664 0.261244400752193 no 2494 0.267724867112163 3539 763655 SGTC_2349 9023730 187.07 µM -0.620540661376841 0.260952992960942 no 2495 0.267450946250703 3556 4126287 SGTC_2093 5331342 194.4 µM -0.620959430335068 0.260806415130405 no 2496 0.26731315835597 3567 33839 SGTC_25 0118-0223 35.662 µM -0.621728067030806 0.260537486592666 no 2497 0.267060346427828 3586 5333628 SGTC_1888 azatryptophan 97.5 µM -0.622232303489755 0.260361143283478 no 2498 0.266894563858327 3521 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_429 1112-0049 25.5 µM -0.624584236020909 0.259539430340607 no 2499 0.266121984283184 3485 2836170 SGTC_1996 st072960 66.8 µM -0.626119127055915 0.259003896592323 no 2500 0.265618403715432 3581 1719405 SGTC_1957 st077035 62.4 µM -0.62706095854278 0.258675568447709 no 2501 0.265309638776069 3613 705593 SGTC_741 4582-0002 126 µM -0.627832982539049 0.258406597003949 no 2502 0.265056678558359 3533 2912688 SGTC_1561 5-methoxyflavone 52.9 µM -0.628287060990096 0.258248464782766 no 2503 0.264907953144037 3541 94525 SGTC_2134 5324836 1.464 µM -0.628651373145464 0.258121629829683 no 2504 0.264788659773858 3491 699272 SGTC_2537 larixol 68.93 µM -0.631604627273024 0.257094650486274 no 2505 0.263822631082643 3584 6708759 SGTC_146 3448-8650 53.125 µM -0.631653072711359 0.257077821560093 no 2506 0.263806799257772 3564 2891488 YIL048W NEO1 SGTC_3000 9075062 71.4286 µM -0.631992921437023 0.256959781370442 no 2507 0.263695751327966 3525 17057871 SGTC_1308 1187-1617 41.4 µM -0.632685482002988 0.256719320536436 no 2508 0.263469526183936 3570 2882570 SGTC_1113 artemisinin 1.17947 µM -0.633051794268483 0.256592182290614 no 2509 0.263349910225909 3572 2240 An anti-malaria and mitochondrial poison. SGTC_1800 st050079 29.0735 µM -0.633189570639014 0.256544371888064 no 2510 0.26330492777498 3548 3645560 SGTC_3254 9136651 49.47 µM -0.633210987011033 0.256536940512511 no 2511 0.263297935920349 3548 16454030 SGTC_2846 9008642 19.48 µM -0.636315833523828 0.255460761743395 no 2512 0.262285293456281 3557 2992898 SGTC_2952 9073731 13.78 µM -0.639046031420597 0.254516393698877 no 2513 0.261396493515321 3549 16457353 SGTC_1181 1222-0449 220 µM -0.639588193683992 0.254329079148848 no 2514 0.261220180024234 3641 658318 SGTC_2842 9000675 19.48 µM -0.64170981080835 0.253596765545444 no 2515 0.260530808977397 3535 2989072 SGTC_287 k060-0039 29.6 µM -0.64192243192612 0.253523436725541 no 2516 0.260461774276423 3608 5861974 SGTC_1092 toremifene 6.32 µM -0.643331803587146 0.253037654105965 no 2517 0.260004411971969 3601 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_571 k831-0106 44.2 µM -0.646311575592878 0.252012199944415 no 2518 0.259038796383558 3568 4783639 SGTC_1767 st044992 70.3 µM -0.647905880018924 0.251464440298086 no 2519 0.258522913703185 3557 9600693 SGTC_2089 5281248 129.67 µM -0.648503366802333 0.251259322284797 no 2520 0.258329716971477 3605 2737878 SGTC_799 1310-0557 151 µM -0.648721045236441 0.25118461497988 no 2521 0.258259349474235 3618 5354492 SGTC_2436 5633522 8.09 µM -0.649097698247263 0.251055375307318 no 2522 0.258137614767148 3602 5724242 SGTC_463 ikarugamyin 104 µM -0.651166760834711 0.250346052777577 no 2523 0.25746942224872 3632 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_448 monastrol 171 µM -0.65167360544443 0.250172456861224 no 2524 0.257305876656978 3547 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3250 9135583 49.47 µM -0.652152203765918 0.250008594014967 no 2525 0.257151494987114 3607 7699353 SGTC_2628 lathosterol 100 µM -0.652177862474681 0.249999810576115 no 2526 0.257143219606726 3647 6710616 SGTC_1979 st071809 45.3 µM -0.652637105008962 0.249842631269147 no 2527 0.256995129315002 3649 4976333 SGTC_2054 5233173 129 µM -0.653385266189652 0.249586679713678 no 2528 0.256753967512925 3592 6889 SGTC_2161 5662504 8.5105 µM -0.654910377549447 0.249065359369335 no 2529 0.256262729169692 3567 2859334 SGTC_482 fipronil 114 µM -0.655050921796093 0.24901734707965 no 2530 0.256217484539082 3626 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3104 9120930 49.47 µM -0.655444408998609 0.248882951400758 no 2531 0.256090833541039 3609 17014836 SGTC_1678 st019265 80.2 µM -0.657304579973567 0.248248132441666 no 2532 0.255492546087058 3642 5367020 SGTC_20 0481-0013 4.944 µM -0.65776004543538 0.248092827820326 no 2533 0.255346165940731 3598 182045 SGTC_2136 5328288 199.296 µM -0.658436732049297 0.247862186943709 no 2534 0.255128769419476 3569 262395 SGTC_1826 st055655 41.6 µM -0.658455655101254 0.247855738883789 no 2535 0.255122691474564 3612 676168 SGTC_2731 amoxapine 43.43 µM -0.658781494176629 0.247744722749684 no 2536 0.255018046243603 3642 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2592 piperlongumine 83.33 µM -0.659584616754456 0.2474712054932 no 2537 0.254760214387111 3565 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1999 st074831 12.5 µM -0.660734653801888 0.24707982166662 no 2538 0.254391248017849 3595 17112523 SGTC_1531 st059297 52.4 µM -0.662249633311342 0.246564745427741 no 2539 0.253905624981405 3628 7566702 SGTC_1244 0416-0015 52.5 µM -0.662869091568599 0.246354302289139 no 2540 0.253707199361143 3629 96201 SGTC_2701 st077767 14.721 µM -0.662950231511312 0.246326744458584 no 2541 0.253681214549267 3612 5721188 SGTC_117 lucigenin 22.078 µM -0.66509751436673 0.245598056472568 no 2542 0.252994062190854 3610 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2068 5226020 147 µM -0.665252750159577 0.245545421574722 no 2543 0.252944423147269 3645 1810509 SGTC_378 3970-0959 8.33 µM -0.665855750106625 0.245341023386663 no 2544 0.252751653230368 3623 6615653 SGTC_3014 9081533 49.47 µM -0.666677692166457 0.24506255800014 no 2545 0.252489015485949 3630 21367265 SGTC_1135 dihydrocapsaicin 536.708 nM -0.667706428146192 0.24471427268245 no 2546 0.252160502968124 3591 107982 A Capsaicinoid. SGTC_1041 0206-0046 107 µM -0.66782757107512 0.244673276495553 no 2547 0.252121832501867 3607 50494 SGTC_406 estrone 100 µM -0.668010397952065 0.244611412740582 no 2548 0.252063477606108 3641 5870 A steroid. SGTC_356 1634-0012 32.5 µM -0.668122446859688 0.244573502532795 no 2549 0.252027717227228 3626 735457 SGTC_1470 k295-0292 231 µM -0.668326621404087 0.244504431019878 no 2550 0.251962561859554 3651 5045612 SGTC_2587 piperic acid 92.2 µM -0.668669998813479 0.244388291381228 no 2551 0.251853004676792 3583 5370536 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.668705140610591 0.244376407140698 no 2552 0.251841793836911 3637 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3015 9080845 49.47 µM -0.668917036337131 0.244304754919808 no 2553 0.251774201026167 3653 5296973 SGTC_630 4356-0227 183 µM -0.669259344495907 0.244189027858018 no 2554 0.251665028074067 3635 779312 SGTC_1982 st072467 71.9 µM -0.669707919716199 0.244037418934271 no 2555 0.25152200103768 3604 3163533 SGTC_1313 1220-0047 237 µM -0.673031378679295 0.24291574347898 no 2556 0.250463664143759 3652 3528706 SGTC_184 1494-0393 24.714 µM -0.673203311176436 0.242857791825305 no 2557 0.250408977477011 3622 3090647 SGTC_999 SEC7.066 22.7 µM -0.675193106219291 0.242187655127877 no 2558 0.249776542960913 3649 740511 YDR170C SEC7 SGTC_729 4092-0585 94.1 µM -0.675320699582512 0.242144717595177 no 2559 0.249736017765844 3622 2169061 SGTC_1583 clindamycin 39.6 µM -0.676179507851037 0.2418558200951 no 2560 0.24946334073907 3566 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3306 9127676 59.7925 µM -0.676991744517183 0.241582761148748 no 2561 0.249205596143341 3636 41905287 SGTC_1395 3486-0190 4.35 µM -0.678601475939509 0.241042094185916 no 2562 0.248695203707611 3665 6748079 SGTC_1486 3970-0793 4.53 µM -0.678807731694985 0.240972865821766 no 2563 0.248629847107822 3667 2844330 SGTC_1279 0874-0590 65.2 µM -0.678826485885578 0.240966571639555 no 2564 0.248623904890449 3654 3523074 SGTC_1617 st002906 78 µM -0.680699147119218 0.240338529430908 no 2565 0.248030938059798 3660 5150859 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.680856871750449 0.240285673411168 no 2566 0.247981029985992 3699 65057 A dermal irritant. YDR527W RBA50 SGTC_1027 k015-0025 8.67 µM -0.681915545743261 0.239931058989802 no 2567 0.247646177426883 3626 3598955 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.68240707853212 0.239766511784797 no 2568 0.247490790535133 3786 16725076 SGTC_1942 st076330 65.2 µM -0.683553237948182 0.23938305881564 no 2569 0.247128660817577 3686 24208414 SGTC_929 2805-0021 398 µM -0.68592172820911 0.238591731675131 no 2570 0.246381233816764 3688 3098024 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.688130941753758 0.237854912285844 no 2571 0.245685163534172 3634 6708514 SGTC_733 4069-0007 56.1 µM -0.688212365393486 0.23782777964511 no 2572 0.24565952908803 3692 5717425 YNL287W SEC21 SGTC_2984 9022109 38.96 µM -0.689285695459725 0.23747027467084 no 2573 0.245321748973824 3700 6459207 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.68954991561277 0.237382313444337 no 2574 0.245238636426705 3731 6728940 SGTC_1049 3226-0134 66 µM -0.690105181088075 0.23719751897032 no 2575 0.245064022610639 3691 5702385 SGTC_2507 purpurin 79.67 µM -0.690833160456975 0.23695536441769 no 2576 0.244835196968452 3651 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1044 1222-0021 1.78 µM -0.691625793940821 0.236691857967322 no 2577 0.244586179441465 3644 4306703 SGTC_785 1270-0111 65.3 µM -0.691712289830878 0.236663112662941 no 2578 0.244559013736419 3659 6741994 SGTC_13 0199-0087 65 µM -0.691887039759774 0.236605043625715 no 2579 0.244504135104624 3690 4589825 SGTC_2925 9010536 32.5 µM -0.691941439088959 0.236586968442102 no 2580 0.244487052842337 3660 2994177 SGTC_1609 st001574 46.4 µM -0.694172651259561 0.235846261918017 no 2581 0.243786970740783 3659 3960012 SGTC_2286 7945697 125 µM -0.694595535828537 0.235706019091001 no 2582 0.243654405344108 3647 1245733 SGTC_2343 7990716 14.84 µM -0.694677174052935 0.235678950391568 no 2583 0.243628817965101 3645 6456862 SGTC_1719 st032227 49.2 µM -0.694751612014169 0.23565427057013 no 2584 0.243605488586136 3678 3125804 SGTC_1965 Pectolinarigenin 58.4 µM -0.697384923008627 0.234782117064545 no 2585 0.242780967209896 3679 5320438 An anti-inflammatory. SGTC_277 nystatin 15.5 µM -0.69790244862387 0.234610922447259 no 2586 0.242619101485974 3663 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2878 9043973 25.97 µM -0.700342789894269 0.233804602038231 no 2587 0.241856627573318 3719 6465167 SGTC_953 1188-0045 9.7 µM -0.700395211696333 0.233787298061478 no 2588 0.241840262888098 3663 6144426 SGTC_3273 9137859 49.47 µM -0.701031731503882 0.233577245102857 no 2589 0.24164160636665 3736 2377234 SGTC_1679 SEC14.276 6.7 µM -0.701206509272877 0.233519586367792 no 2590 0.241587074091491 3711 1005053 YMR079W SEC14 SGTC_834 0312-0008 75.7 µM -0.701766914305011 0.233334763438197 no 2591 0.24141226762596 3681 6385573 YIL048W NEO1 SGTC_2020 4017018 200 µM -0.702776061179594 0.233002149146529 no 2592 0.241097659003385 3730 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2154 5570129 200 µM -0.703179916219721 0.232869112543669 no 2593 0.240971816841396 3689 673366 SGTC_2823 7987624 58.44 µM -0.704805372508409 0.2323340870175 no 2594 0.240465682344558 3702 2239440 SGTC_3347 9188721 44.724 µM -0.705101911615607 0.232236553779662 no 2595 0.240373408497696 3704 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2872 9044037 25.97 µM -0.705466265846905 0.232116746999817 no 2596 0.24026005908468 3680 6465195 SGTC_1290 0986-0249 10.2 µM -0.706927068978304 0.231636752064605 no 2597 0.239805900605983 3641 53329 SGTC_3198 9112019 49.47 µM -0.707066714137818 0.23159089603845 no 2598 0.239762509964046 3726 45595555 SGTC_3005 9076496 71.4286 µM -0.707764832957886 0.231361726928481 no 2599 0.239545654246582 3699 21368410 SGTC_345 1362-0200 395 µM -0.708262884274353 0.231198310632113 no 2600 0.239391010700403 3689 1419823 SGTC_1352 1496-0991 99 µM -0.708387545069544 0.231157418087785 no 2601 0.239352312404257 3681 3000039 SGTC_2393 9031399 185.94 µM -0.709444359573476 0.230810912864341 no 2602 0.239024384097537 3714 1526623 YDL150W RPC53 SGTC_197 4544-0043 41.561 µM -0.710127718594855 0.230587009645839 no 2603 0.23881246942163 3691 896523 SGTC_2885 9057732 51.95 µM -0.710197091706384 0.230564286269609 no 2604 0.238790962055302 3698 6471414 SGTC_3263 9137018 49.47 µM -0.711813751094169 0.230035099029215 no 2605 0.238290058162891 3650 43844957 SGTC_2005 4024620 188 µM -0.713137315822562 0.229602358062114 no 2606 0.2378803952469 3700 236743 SGTC_2242 6630449 61.2675 µM -0.714065592171624 0.229299129360657 no 2607 0.237593310513649 3734 691249 YDR170C SEC7 SGTC_1458 k015-0034 6.33 µM -0.715334899712731 0.228884863794427 no 2608 0.237201064197213 3717 3598957 SGTC_1675 st018485 24.5 µM -0.716108781581484 0.228632497213342 no 2609 0.236962090900698 3742 3323024 SGTC_1028 k015-0029 4.8 µM -0.718117817008486 0.227978071104163 no 2610 0.236342322635788 3699 4588309 SGTC_295 k015-0027 31 µM -0.719052101329077 0.227674095290448 no 2611 0.236054409137715 3669 3887424 SGTC_2627 acetyl isogambogic acid 100 µM -0.720125327280496 0.227325195623682 no 2612 0.235723917358771 3689 6857789 A caspase activator and apoptosis inducer. SGTC_3272 9137413 49.47 µM -0.720396227549631 0.227237175125403 no 2613 0.235640536029541 3665 17614870 SGTC_424 splitomicin 100 mM -0.720553723468816 0.22718601062454 no 2614 0.235592067296081 3751 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2889 9059656 51.95 µM -0.720704366771366 0.227137078357252 no 2615 0.235545712574094 3784 3949838 SGTC_2603 homopterocarpin 100 µM -0.721070592859896 0.227018144827413 no 2616 0.235433041474027 3746 101795 A weak amylase inhibitor. SGTC_2814 7977482 42.97 µM -0.721949015431326 0.226733016417847 no 2617 0.235162912096802 3768 6456762 SGTC_1339 1486-1321 22.7 µM -0.722034959523019 0.226705130561846 no 2618 0.235136492071945 3748 3469382 SGTC_2922 7999257 32.47 µM -0.722383230253631 0.226592148688294 no 2619 0.235029447146014 3691 2988377 SGTC_1016 4226-1401 38 µM -0.72413159670778 0.226025444836014 no 2620 0.234492474078749 3705 2901613 SGTC_1667 st014849 34.6 µM -0.725089728649336 0.225715222482631 no 2621 0.234198492638503 3767 5348460 SGTC_1883 5-benzylidenerhodanine 20 µM -0.726442270152366 0.225277709153011 no 2622 0.233783842973005 3717 1273210 SGTC_1128 3448-9350 235 µM -0.728183249761673 0.224715253453213 no 2623 0.233250709021064 3766 619386 SGTC_163 TUB2.036 7.546 µM -0.728636342574816 0.224569004142483 no 2624 0.233112070769051 3771 15992207 YJR013W GPI14 SGTC_2680 butyl paraben 22.24 µM -0.729208586760087 0.224384372340239 no 2625 0.232937039738041 3768 7184 An antifungal and steroid mimetic. SGTC_1283 0922-0125 16.4 µM -0.730340013186924 0.224019576810255 no 2626 0.23259118784878 3729 3360884 SGTC_1122 capsaicin 818.572 nM -0.730586910419555 0.223940016789036 no 2627 0.232515754820577 3799 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_888 0916-0002 6.97 µM -0.730916441112261 0.223833854028655 no 2628 0.232415096485836 3787 2802138 YIL048W NEO1 SGTC_3188 9110789 49.47 µM -0.73109241851027 0.223777172253463 no 2629 0.232361352418038 3729 849217 SGTC_2750 bromebric acid 70.15 µM -0.732936916659412 0.223183556279999 no 2630 0.231798452876611 3779 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_578 3460-0051 92 µM -0.733658130361843 0.222951691641847 no 2631 0.23157856136 3796 2876744 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.7353392553631 0.222411755942684 no 2632 0.231066453257961 3691 4620898 SGTC_1381 2324-0066 62.1 µM -0.735581182177309 0.222334116477125 no 2633 0.230992809023362 3761 10885928 SGTC_1121 fusaric acid 630.51 nM -0.736918508333315 0.221905219098451 no 2634 0.230585953961419 3747 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1334 1486-0610 236 µM -0.737224870798172 0.221807031349885 no 2635 0.230492805642126 3794 3742339 SGTC_2034 5197015 53.07 µM -0.737324694092336 0.221775043808529 no 2636 0.230462459300258 3716 780676 SGTC_831 k061-1017 217 µM -0.737395696177324 0.221752293386965 no 2637 0.230440875982707 3793 1240153 SGTC_1699 st031318 29.054 µM -0.738166942350848 0.221505257324477 no 2638 0.230206504255717 3805 5340658 SGTC_2516 gossypol 71.55 µM -0.738722942429094 0.221327263864569 no 2639 0.230037625771255 3762 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1300 1094-0077 113 µM -0.739751691675715 0.220998144013235 no 2640 0.229725338170346 3692 5532636 SGTC_3325 9138760 55.175 µM -0.741478099206734 0.220446457655811 no 2641 0.229201803028965 3727 43844959 SGTC_3298 9116858 71.43 µM -0.741651401791488 0.220391121153715 no 2642 0.229149285792037 3758 2506942 SGTC_2786 7743617 45.45 µM -0.742973499068534 0.219969230113488 no 2643 0.228748862527893 3703 583674 SGTC_1402 3909-7673 35.9 µM -0.74405169108007 0.219625514369056 no 2644 0.228422601810112 3753 5328014 SGTC_78 0336-0123 156.75 µM -0.744572496133921 0.219459597985258 no 2645 0.22826509999066 3623 6765896 SGTC_2326 6164455 177.58 µM -0.74674285465856 0.218768948011097 no 2646 0.22760939803696 3747 2888790 SGTC_2715 st079500 56.4 µM -0.747393506938077 0.218562141846922 no 2647 0.227413031815569 3700 28246688 SGTC_931 2812-0076 566 µM -0.748065182106297 0.218348771796061 no 2648 0.227210421052483 3776 3450959 SGTC_346 4513-0042 7.16 µM -0.748095683915093 0.218339085180949 no 2649 0.227201222599773 3732 2827372 SGTC_516 3992-2719 87.3 µM -0.750159024755954 0.217684394496541 no 2650 0.226579466926084 3729 5350887 YDR037W KRS1 SGTC_3038 9091290 49.47 µM -0.750602525311209 0.217543821391007 no 2651 0.226445950453126 3766 25236843 SGTC_362 0310-0100 9.03 µM -0.751068891119488 0.217396057385834 no 2652 0.226305598298434 3827 790235 SGTC_1021 4476-0760 85.3 µM -0.751984203220353 0.21710621713942 no 2653 0.226030279284222 3773 746768 SGTC_1285 0929-0069 65.5 µM -0.752722501945618 0.216872592231577 no 2654 0.225808342587157 3778 1206237 SGTC_2350 9023895 38.85 µM -0.753103660705913 0.216752036468461 no 2655 0.225693812404508 3774 2997209 SGTC_2911 7942208 15.64 µM -0.755024432138515 0.216145110412555 no 2656 0.2251171613764 3758 1243384 SGTC_264 promethazine 12.5 mM -0.755043686085536 0.216139031529775 no 2657 0.225111385215076 3761 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_254 nsc-64875 3.808 µM -0.756334401171792 0.215731751016212 no 2658 0.224724363754223 3794 56993 SGTC_112 phenothiazine 287.218 µM -0.759641071910378 0.214690375085612 no 2659 0.223734580769619 3730 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1407 3909-7909 12.3 µM -0.759891495471958 0.214611627906224 no 2660 0.22365972278401 3757 4411780 SGTC_181 1447-1644 8.07 µM -0.760919283027997 0.214288609891641 no 2661 0.223352640100924 3737 534600 SGTC_1822 st052468 42 µM -0.765426002415658 0.212875559346086 no 2662 0.222008957099233 3788 2873678 SGTC_970 1315-0089 19.5 µM -0.765509905465266 0.212849303798173 no 2663 0.221983985158263 3735 6811083 YLR033W RSC58 SGTC_748 act1.228 77.9 µM -0.765572719879133 0.212829648695657 no 2664 0.221965290846695 3725 4421505 YNR035C ARC35 SGTC_707 0865-0008 204 µM -0.765633895259948 0.212810507477276 no 2665 0.221947085194814 3773 723043 SGTC_528 3492-0019 172 µM -0.766019893012156 0.21268975547913 no 2666 0.221832232821374 3794 2869262 SGTC_536 3852-0578 10.6 µM -0.767614464609591 0.21219134850568 no 2667 0.221358133177626 3801 2869208 SGTC_3067 9117431 49.47 µM -0.770230456439433 0.211375162064098 no 2668 0.220581600236302 3832 17150885 SGTC_354 2783-3500 4.88 µM -0.770768838594857 0.211207415897899 no 2669 0.220421980355682 3802 6740761 SGTC_3166 9102297 49.47 µM -0.77162884760124 0.210939620877032 no 2670 0.22016714173411 3773 25237072 SGTC_2860 9025725 38.96 µM -0.772790129568838 0.210578329669188 no 2671 0.219823297923501 3781 40546248 SGTC_2367 9070478 135.38 µM -0.772814665256586 0.21057070018966 no 2672 0.219816036481771 3756 572802 SGTC_2347 9049783 174.81 µM -0.774277244883039 0.210116197756509 no 2673 0.219383428578859 3788 6467988 YPL169C MEX67 SGTC_3348 9149464 3.537 µM -0.775800008920522 0.20964360567996 no 2674 0.218933539347557 3778 1951442 SGTC_26 0302-0163 425.158 µM -0.775901310765752 0.209612188693959 no 2675 0.218903629314734 3826 3100915 SGTC_1895 st058434 18.3 µM -0.776031521680554 0.209571810135729 no 2676 0.218865187142806 3778 5393175 SGTC_1641 st009299 47.1 µM -0.776407077913589 0.209455375335474 no 2677 0.218754333424526 3723 4046054 SGTC_2065 5221596 34.26 µM -0.777729694188907 0.209045623891001 no 2678 0.218364191383595 3784 788581 SGTC_1198 1612-1005 86.7 µM -0.777899023158843 0.208993199254364 no 2679 0.21831427210521 3854 6998509 SGTC_1417 3966-0327 90.4 µM -0.778487446701382 0.208811082197815 no 2680 0.218140852156065 3856 651118 SGTC_2630 antimycin a 100 µM -0.780364668530779 0.208230707504977 no 2681 0.217588129067517 3796 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_485 niflumic acid 177 µM -0.780428151649491 0.208211097283664 no 2682 0.217569451443854 3855 4488 A COX2 inhibitor. SGTC_2867 9039098 71.43 µM -0.782397251048409 0.207603374895275 no 2683 0.216990574421572 3771 6463460 SGTC_796 1234-0020 70.7 µM -0.78256574952367 0.207551420003392 no 2684 0.216941080517197 3734 46495034 SGTC_2623 humulene 100 µM -0.783784638984115 0.207175815998471 no 2685 0.216583244368916 3758 6187145 An anti-inflammatory. SGTC_3138 9097216 49.47 µM -0.784972436085584 0.206810180261224 no 2686 0.216234864906682 3798 25237486 SGTC_188 3229-0966 278.469 µM -0.785776841837222 0.206562779735532 no 2687 0.215999118046548 3867 5722370 SGTC_681 1642-0006 26.6 µM -0.785906722580054 0.206522850462682 no 2688 0.21596106791735 3839 4446530 SGTC_1621 st003705 32.4 µM -0.787950632174091 0.205895093103206 no 2689 0.2153627915803 3844 24207032 SGTC_1575 cyproterone acetate 48 µM -0.788678488163467 0.20567181624751 no 2690 0.215149972003945 3830 9880 An androgen receptor antagonist and liver toxin. SGTC_1447 4239-0816 81.9 µM -0.789658037883715 0.205371556861227 no 2691 0.21486375188113 3821 1341554 SGTC_752 1896-0090 130 µM -0.789950336376648 0.205282009658983 no 2692 0.214778386413846 3793 772567 SGTC_351 caspofungin 25 nM -0.790257625925115 0.205187894881475 no 2693 0.214688664075455 3830 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3163 9099914 49.47 µM -0.791464539090762 0.204818497021066 no 2694 0.214336480664283 3827 16268368 SGTC_3241 9133421 49.47 µM -0.793627597485561 0.20415744383657 no 2695 0.213706130688764 3828 17018221 SGTC_3030 9087619 49.47 µM -0.794182995708744 0.203987913604684 no 2696 0.213544453121275 3853 25236973 SGTC_1163 k060-0048 49.9 µM -0.79463387993784 0.203850347021496 no 2697 0.213413252227481 3829 6809982 SGTC_2152 5568786 200 µM -0.794691324528491 0.203832824418922 no 2698 0.21339654004433 3801 5399883 SGTC_2170 morpholine 200 µM -0.794751569721177 0.203814448499617 no 2699 0.21337901391 3849 121171 Reacts with secondary amines. SGTC_1844 rapamycin 4 nM -0.795775911476837 0.203502156112321 no 2700 0.213081147607099 3761 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1431 4049-0260 9.09 µM -0.795961011608614 0.203445754860916 no 2701 0.21302734859558 3796 3854841 SGTC_3309 9129340 25.759 µM -0.79688387006222 0.203164692880525 no 2702 0.212759239768382 3868 17158987 SGTC_903 1134-0042 114 µM -0.797377433903783 0.203014470283822 no 2703 0.212615930495788 3825 701009 SGTC_3279 9140807 49.47 µM -0.797985472966797 0.202829496877982 no 2704 0.212439460169558 3866 45595718 SGTC_1301 naphtanilide LB 4.81 µM -0.797985714687811 0.202829423363326 no 2705 0.212439390032228 3873 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3047 9092122 49.47 µM -0.799785024846337 0.202282640005092 no 2706 0.211917680424453 3813 17173831 SGTC_1252 0493-0875 34.8 µM -0.800237976684351 0.202145133774946 no 2707 0.21178646531085 3825 3960963 SGTC_2883 9059145 45.46 µM -0.800687132317876 0.202008835230984 no 2708 0.211656396872154 3822 16476510 SGTC_1409 3909-8004 61.9 µM -0.800733448347677 0.20199478352706 no 2709 0.211642987134959 3829 2119279 SGTC_607 4491-0986 66.8 µM -0.800822961967864 0.201967627872712 no 2710 0.211617071942082 3825 698981 YDR232W HEM1 SGTC_647 0140-0236 81 µM -0.80147819377846 0.201768917426213 no 2711 0.211427431585469 3843 990837 SGTC_843 0310-0051 143 µM -0.802115926804479 0.201575626263771 no 2712 0.21124295142266 3871 2065037 SGTC_520 3584-0023 682 µM -0.802430408311063 0.201480350593551 no 2713 0.211152014544481 3857 1340790 SGTC_2187 6125751 200 µM -0.802506510553239 0.201457298628705 no 2714 0.211130011927928 3834 874498 SGTC_3233 9132340 49.47 µM -0.803733321803661 0.201085906048185 no 2715 0.210775502745755 3844 17682950 SGTC_871 0574-0004 149 µM -0.804101216812855 0.200974613275442 no 2716 0.210669260951613 3816 9551173 SGTC_1911 st060208 74.3 µM -0.804332071136035 0.200904795871501 no 2717 0.21060261021245 3897 688783 SGTC_663 1486-0733 13.9 µM -0.807639420609768 0.199906150873785 no 2718 0.209649093282765 3859 722445 YPR165W RHO1 SGTC_46 0329-0187a 2.197 µM -0.807992385738624 0.199799750609362 no 2719 0.20954748272292 3911 46494817 SGTC_1020 4335-0961 93.3 µM -0.808810234037922 0.199553343671599 no 2720 0.209312154323152 3793 669075 SGTC_1359 1582-0056 520 nM -0.809244011046624 0.199422726622765 no 2721 0.209187402092081 3934 3661189 SGTC_1572 epiandrosterone 68.9 µM -0.809928753949447 0.19921664459592 no 2722 0.208990562361325 3764 441302 A steroid. SGTC_2149 5554786 194.827 µM -0.81057065394708 0.199023573210635 no 2723 0.208806137579429 3876 745063 YPR165W RHO1 SGTC_792 4534-1957 155 µM -0.810693581698543 0.198986611734379 no 2724 0.208770830056772 3817 1717904 SGTC_34 0469-0683 81.75 µM -0.810925367172055 0.198916930561813 no 2725 0.208704265801566 3828 3690923 SGTC_69 0096-0274 206.684 µM -0.811504439758511 0.198742909483569 no 2726 0.20853802215093 3951 6741392 SGTC_1774 st048371 48.465 µM -0.811542775224719 0.198731392269896 no 2727 0.208527019330283 3823 4242727 SGTC_927 2425-1185 123 µM -0.811754524350468 0.198667783236121 no 2728 0.208466250505595 3819 730375 SGTC_137 0438-0332 85.389 µM -0.811942486127323 0.198611330164208 no 2729 0.208412317043891 3851 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.811943185489955 0.198611120133351 no 2730 0.208412116385227 3853 641818 YHR062C RPP1 SGTC_2276 7947513 42.08 µM -0.814379629475454 0.197880226680129 no 2731 0.207713752342509 3766 2105100 SGTC_2785 7756463 72.73 µM -0.814527247100961 0.197835996067682 no 2732 0.207671484795392 3826 2201551 SGTC_3280 9140961 49.47 µM -0.816120262448452 0.197359061619279 no 2733 0.207215678028453 3888 4901226 SGTC_960 1222-0186 7.7 µM -0.817138854055499 0.197054469262425 no 2734 0.20692454051528 3925 3126296 SGTC_1460 k062-0059 9.15 µM -0.817221271187193 0.197029836279842 no 2735 0.206900994345539 3756 1373085 SGTC_1763 st044482 94.5 µM -0.819013385466005 0.196494666876998 no 2736 0.206389388342111 3899 88505 SGTC_3159 9100096 49.47 µM -0.819022136121365 0.196492055878988 no 2737 0.206386892078604 3812 25236875 SGTC_2305 7443522 69.23 µM -0.819863383437913 0.196241144843693 no 2738 0.206146996454317 3794 5415886 SGTC_3284 9108171 64.8615 µM -0.820796336534212 0.195963108875253 no 2739 0.20588114283792 3840 8687505 SGTC_1289 0976-0073 69.1 µM -0.821061665888287 0.19588407986247 no 2740 0.205805571948142 3922 3391136 SGTC_693 4161-2696 114 µM -0.821648716397096 0.195709294141173 no 2741 0.205638427207259 3898 805759 SGTC_2966 9084041 48.03 µM -0.823490655969019 0.195161498343271 no 2742 0.205114514339623 3811 17741380 SGTC_326 k292-0812 17.5 µM -0.824085075888063 0.194984915983054 no 2743 0.204945609708618 3819 3579357 SGTC_3001 9076041 71.4286 µM -0.824223284300806 0.194943872789955 no 2744 0.204906349590659 3848 16004211 SGTC_2304 7443016 91.4 µM -0.824897038454259 0.19474386598087 no 2745 0.204715023927704 3802 939854 SGTC_1792 st045773 43.6 µM -0.825469363881009 0.194574066817672 no 2746 0.204552584437868 3782 2919270 SGTC_3216 9129716 49.47 µM -0.825688257704321 0.194509148590937 no 2747 0.204490477477435 3851 8056934 SGTC_2852 9023854 51.95 µM -0.826139165970433 0.194375462456279 no 2748 0.204362576205648 3948 19798528 SGTC_1721 st082152 9.2685 µM -0.82694641468173 0.194136267595229 no 2749 0.204133717048673 3808 5296051 SGTC_1718 roemerine 11.9335 µM -0.827157309391373 0.194073807198469 no 2750 0.204073952474669 3714 235224 An aporphine alkaloid with mutagenic activity. SGTC_3054 9094397 49.47 µM -0.828734077129365 0.193607206111524 no 2751 0.203627449218064 3897 2598354 SGTC_1897 st060201 15 µM -0.831559131854339 0.1927729215812 no 2752 0.202828919099386 3923 611878 SGTC_11 0438-0307 1.3 µM -0.831979216229964 0.19264905170328 no 2753 0.202710338004621 3872 4011476 SGTC_1510 1123-0200 71.5 µM -0.832509623615755 0.192492720485476 no 2754 0.202560674205451 3928 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3033 9090887 49.47 µM -0.833654408997733 0.19215557314975 no 2755 0.202237878030659 3909 19325384 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.836763140666903 0.191241853996554 no 2756 0.201362859910576 3873 16486 A toxic proline analog. SGTC_3078 9116413 49.47 µM -0.837358900000481 0.191067052877751 no 2757 0.201195430359989 3808 17177322 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.837411397802444 0.191051654251763 no 2758 0.201180680614549 3854 15053 SGTC_98 0074-0023 107.663 µM -0.840257388381499 0.190218009216879 no 2759 0.200382043821372 3868 3563821 SGTC_344 k064-0035 6.43 µM -0.841093506559177 0.189973519590787 no 2760 0.200147776276069 3857 5088750 SGTC_3147 9097027 49.47 µM -0.841098147939307 0.189972162942455 no 2761 0.200146476291837 3909 25236841 SGTC_1330 1469-0054 61.8 µM -0.84121405715832 0.189938285285435 no 2762 0.200114013422243 3916 7102664 SGTC_15 0266-0086 27.098 µM -0.841556493358901 0.189838220584224 no 2763 0.20001812528842 3963 1712902 YIL048W NEO1 SGTC_363 0455-0021 3.06 µM -0.842490085210244 0.189565576537014 no 2764 0.199756843571836 3885 4597466 SGTC_495 decylubiquinone 155 µM -0.842603989471869 0.189532328692139 no 2765 0.199724979567026 3939 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1387 3342-1166 1.8 µM -0.843802738433237 0.189182640001642 no 2766 0.199389822508705 3883 3418228 SGTC_3344 9148862 3.898 µM -0.845316102156846 0.188741742386095 no 2767 0.19896718653931 3926 4905352 SGTC_712 r015-0009 80.6 µM -0.845984842832195 0.18854711595406 no 2768 0.198780599942873 3928 6813872 YLR060W FRS1 SGTC_1786 berberine 21.6 µM -0.846968971178554 0.18826092606211 no 2769 0.198506208365644 3838 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1573 oleylamine 1.06 µM -0.847559381460887 0.188089360230335 no 2770 0.198341701737927 3899 5356789 An amine of the fatty acid oleic acid. SGTC_1068 loratadine 26.9 µM -0.849003522327643 0.187670117862147 no 2771 0.197939666154993 3959 3957 A H1 histamine antagonist. SGTC_2377 9073351 62.6 µM -0.849919085365229 0.187404623921766 no 2772 0.197685036941726 3876 7337946 YHR072W ERG7 SGTC_1471 k673-0312 37 µM -0.851417370264983 0.186970654074774 no 2773 0.19726877299067 3867 24099884 SGTC_912 3474-0017 2.18 µM -0.853666540935672 0.186320362707873 no 2774 0.196644889053694 3954 3360550 SGTC_545 4218-0007 221 µM -0.85384183584029 0.186269739507258 no 2775 0.196596315312306 3900 2840508 SGTC_1801 st050089 28.441 µM -0.855811694353254 0.185701452629507 no 2776 0.196050972820609 3936 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_209 4077-0173 175.592 µM -0.855873637707955 0.185683599976734 no 2777 0.196033839100366 3873 15993494 SGTC_592 k241-0073 46.5 µM -0.856899755079117 0.185388018311347 no 2778 0.195750144081403 3904 4230158 SGTC_3256 9138902 49.47 µM -0.85719269181089 0.185303689070039 no 2779 0.195669200369003 3959 17228773 SGTC_2906 7926292 26.41 µM -0.859298800550582 0.18469809387465 no 2780 0.195087842882783 3903 2966319 SGTC_2224 6650123 117.647 µM -0.860139243433258 0.184456774930389 no 2781 0.194856145518711 3870 2908370 SGTC_2833 9001315 45.46 µM -0.860474591842506 0.184360540078726 no 2782 0.194763741775544 3905 2989378 SGTC_2679 rapamycin 1 nM -0.862038217589461 0.183912239283031 no 2783 0.194333243747432 3873 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2566 crystal violet carbinol 226 nM -0.863985647785368 0.183354849646661 no 2784 0.193797887417383 3971 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2189 6047310 154.431 µM -0.8657515285999 0.182850334303226 no 2785 0.193313217785927 3872 711535 SGTC_1241 0364-0022 50.8 µM -0.8660948920387 0.182752335460479 no 2786 0.193219063061182 3946 4563895 SGTC_2423 st077119 87.2 µM -0.866808172295501 0.182548864043978 no 2787 0.19302356181711 3858 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2047 4141938 200 µM -0.867553776072878 0.182336323284048 no 2788 0.192819330273144 3932 3807862 SGTC_488 nitrendipine 139 µM -0.870052475666007 0.181625175496962 no 2789 0.192135863747513 3970 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1693 xanthone 101.9 µM -0.870519081150002 0.181492568812424 no 2790 0.192008398098453 3980 7020 An insecticide. SGTC_5 0352-0601 109.883 µM -0.870524054138942 0.181491155843083 no 2791 0.192007039873558 3855 762456 SGTC_14 0354-0009 295 µM -0.871357830077617 0.181254353454982 no 2792 0.191779401769485 4007 1713507 SGTC_800 3448-7362 155 µM -0.873760529620182 0.180573040774579 no 2793 0.191124339799492 4008 15991913 SGTC_2031 5180455 200 µM -0.875546611654976 0.180067619142663 no 2794 0.190638279983857 3894 29949 SGTC_2614 arthonioic acid 13.39 µM -0.876815328329748 0.179709140510384 no 2795 0.190293476003948 3848 6710684 SGTC_721 1187-1332 279 µM -0.877778781740448 0.179437214429473 no 2796 0.190031890676845 3879 25730 SGTC_555 4296-0685 37 µM -0.877838813481097 0.179420279574485 no 2797 0.190015598895685 3878 2908540 YHR072W ERG7 SGTC_521 r062-0005 13.8 µM -0.878920812232346 0.179115221792398 no 2798 0.189722106651655 3849 2832033 SGTC_3022 9087993 49.47 µM -0.880011488002275 0.17880804805045 no 2799 0.189426543106517 3991 17173644 SGTC_2268 7933382 153.85 µM -0.882414589620064 0.178132418780954 no 2800 0.188776324433806 3960 935025 YOR257W CDC31 SGTC_3002 9075603 71.4286 µM -0.882551042952222 0.178094103427106 no 2801 0.188739444921554 3897 20105405 SGTC_2991 9074669 71.4286 µM -0.883353463415373 0.177868893246305 no 2802 0.188522663004225 3936 17333109 SGTC_114 0364-0001 490.298 µM -0.885596799878024 0.177240224036104 no 2803 0.187917418315278 4014 4003655 SGTC_3056 9094900 49.47 µM -0.885639221158684 0.177228349495662 no 2804 0.187905984765742 3932 25236784 SGTC_2059 5238311 157 µM -0.887408198169199 0.176733625849981 no 2805 0.187429585644306 3953 703021 SGTC_1547 harmine 94.2 µM -0.888067765179172 0.176549390707058 no 2806 0.187252150408234 3942 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_657 3534-0529 86.7 µM -0.889174682614922 0.176240471419749 no 2807 0.186954603477647 4007 1049549 SGTC_730 1436-0052 41.2 µM -0.890211705211358 0.175951368993258 no 2808 0.186676110326816 3965 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_248 streptozotocin 5.23457 mM -0.8915100591284 0.175589835918404 no 2809 0.186327798748192 3960 5300 DNA alkylating agent. SGTC_2830 7992007 71.43 µM -0.893778153213284 0.17495940426504 no 2810 0.185720300178543 3849 1952075 SGTC_2730 imipramine 71.33 µM -0.894029348438306 0.174889671351378 no 2811 0.18565309435295 3949 3696 A tricyclic antidepressant. SGTC_1406 3909-7906 11.9 µM -0.896355925513855 0.174244641625929 no 2812 0.185031349444564 3966 X1406 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.897096167821602 0.174039731249927 no 2813 0.184833801712508 3944 6312947 SGTC_649 1123-0311 367 µM -0.898842226967619 0.173557002547405 no 2814 0.184368352162189 3887 693629 YIL048W NEO1 SGTC_1393 3470-5649 58.2 µM -0.89900578239466 0.173511828463746 no 2815 0.184324790336045 3947 4108395 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.900328838368675 0.173146674945072 no 2816 0.183972639255422 3990 91467 include heat shock SGTC_1274 0865-0114 173 µM -0.904431878106807 0.172017381960053 no 2817 0.182883220524502 3999 870624 SGTC_804 1595-0054 20.9 µM -0.904456365341965 0.172010656404132 no 2818 0.182876730905329 3910 761523 Stimulates phospholipase C. SGTC_1863 st057641 20.1 µM -0.908181277783395 0.170989543648688 no 2819 0.181891227004043 3979 3921635 SGTC_1945 st075991 56.6 µM -0.908340587421688 0.170945958633823 no 2820 0.181849152488541 4006 1084980 SGTC_302 1094-0063 18.9 µM -0.910818234748706 0.170269022046999 no 2821 0.181195576503333 3943 5440289 SGTC_3053 9095903 49.47 µM -0.916528327843119 0.168715474472989 no 2822 0.179694928319735 4083 17174018 SGTC_2336 9001819 198.65 µM -0.917837665933377 0.168360530239866 no 2823 0.179351929795563 4031 2989602 SGTC_1213 1315-0166 115 µM -0.918174779449287 0.168269221024629 no 2824 0.179263685110357 4094 768401 SGTC_2057 5236571 38.335 µM -0.918762057783206 0.168110229268255 no 2825 0.179110021138508 3987 54684039 YBR257W POP4 SGTC_1144 3486-0183 12.5 µM -0.919305174951645 0.167963279168974 no 2826 0.178967985905393 3983 6744069 SGTC_2895 9054447 58.44 µM -0.920024207627881 0.167768859197118 no 2827 0.178780054563254 4034 2697450 SGTC_1983 st071813 46.9 µM -0.920291481967233 0.167696627576016 no 2828 0.178710229581133 4056 11838595 SGTC_908 3448-7491 47.7 µM -0.921668498651686 0.167324802504501 no 2829 0.178350758404133 4009 1203031 SGTC_2181 6316240 54.2555 µM -0.92272042155501 0.167041118225756 no 2830 0.178076460363826 4025 12779990 SGTC_1969 st069479 40.1 µM -0.92380898345087 0.16674787981942 no 2831 0.177792888565902 4009 3895485 SGTC_1056 3448-1962 115 µM -0.925161769434497 0.166383927494759 no 2832 0.177440883246786 4002 715507 SGTC_2254 7938975 95.19 µM -0.925544766487337 0.166280979548958 no 2833 0.177341304433409 4087 2969277 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.926406057960301 0.166049618450725 no 2834 0.177117498522763 4010 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_97 0535-0701 19.132 µM -0.928740972273439 0.165423457901022 no 2835 0.176511670839363 3914 2832013 YGL099W LSG1 SGTC_1126 isoteolin 1.0172 µM -0.930826143294462 0.164865564649266 no 2836 0.175971751981298 3949 133323 SGTC_3023 9089636 49.47 µM -0.9373213812493 0.16313556562819 no 2837 0.1742966339453 4081 17249241 SGTC_972 1319-0219 195 µM -0.938703648679247 0.162768928383073 no 2838 0.173941459802218 3988 23903702 SGTC_524 r073-0010 27.8 µM -0.939281339162717 0.162615858734525 no 2839 0.173793158468446 3934 2772106 SGTC_2090 5301565 104.445 µM -0.939506437181794 0.162556240264391 no 2840 0.173735394397315 4018 2056344 SGTC_1519 esterone 74 µM -0.940407996394802 0.162317599828042 no 2841 0.173504161040933 3986 698 A steroid. SGTC_2222 6885208 172.143 µM -0.940818651329749 0.162208976143449 no 2842 0.173398900560834 3955 609514 SGTC_2171 5739187 198.077 µM -0.943693331615714 0.161449910673865 no 2843 0.172663191315475 3957 2262761 SGTC_3046 9092212 49.47 µM -0.944083091423817 0.161347172363275 no 2844 0.172563594552789 4076 25236637 SGTC_816 0325-0417 81.3 µM -0.946057333258863 0.160827429394916 no 2845 0.172059672137168 4051 68101 SGTC_2654 protoveratrine a 100 µM -0.948011972072025 0.160313925213839 no 2846 0.171561679725769 4017 5702278 A heart drug and vasodilator. SGTC_300 r073-0011 5.04 µM -0.951147287687583 0.159492485173888 no 2847 0.170764806332057 4027 2735780 SGTC_560 2332-1943 155 µM -0.951250846696918 0.159465400219684 no 2848 0.17073852619989 3992 21177716 SGTC_1168 k815-0004 80.5 µM -0.952154750397468 0.159229119949514 no 2849 0.170509252798496 4024 642433 SGTC_1915 st067105 30.6 µM -0.954176839652743 0.158701376809334 no 2850 0.169997068009727 3996 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2800 7887935 81.82 µM -0.955262144345021 0.158418597641765 no 2851 0.169722573061516 4061 2961002 SGTC_1194 1488-0194 225 µM -0.955991596947162 0.158228722577015 no 2852 0.169538239951808 3988 1391452 SGTC_1816 st051957 91.6 µM -0.957771867155756 0.157765949038762 no 2853 0.169088904118994 4017 674121 SGTC_867 0518-0118 155 µM -0.958167256546197 0.157663290045529 no 2854 0.168989212690185 4008 6848158 SGTC_614 0462-0418 107 µM -0.960611287730149 0.157029695463203 no 2855 0.168373825505168 3834 5188303 SGTC_2964 9083345 53.42 µM -0.961386655785498 0.156829038233804 no 2856 0.168178895649414 4044 17741579 SGTC_2403 6032726 181.2 µM -0.961699770125197 0.156748055328262 no 2857 0.168100218936268 4112 2881040 SGTC_1389 3405-0187 19 µM -0.96182360357742 0.156716035030582 no 2858 0.168069109654271 4017 799890 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.961953209911647 0.156682526618209 no 2859 0.168036554084408 4002 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2295 7971645 200 µM -0.963435562813694 0.156299614644327 no 2860 0.167664493343717 4100 2978226 YKL099C UTP11 SGTC_1316 1272-0050 65.9 µM -0.967715940693225 0.155197397237061 no 2861 0.16659312737106 4008 7340392 SGTC_1100 amiodarone 5.07 µM -0.968040040287442 0.155114149541586 no 2862 0.166512186538754 4151 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_159 3970-0959 50 µM -0.968635611485439 0.154961248970516 no 2863 0.166363514420131 4133 6615653 SGTC_76 0433-0009 400.328 µM -0.969351638395184 0.154777555706043 no 2864 0.166184886516317 4146 2841569 SGTC_2897 9048598 12.99 µM -0.969966186642491 0.154620011073841 no 2865 0.166031673425446 4038 6467404 SGTC_77 0828-0286 12.516 µM -0.971089713510195 0.154332259548797 no 2866 0.165751802863246 3974 745345 SGTC_3045 9092950 49.47 µM -0.971941217204541 0.154114413130905 no 2867 0.165539896572088 4007 44120432 SGTC_2264 7948757 110.76 µM -0.972599892784028 0.153946038940503 no 2868 0.165376097980845 4016 2971411 SGTC_3274 9138298 49.47 µM -0.972736585367044 0.153911112105794 no 2869 0.165342118589635 4018 17015756 SGTC_1741 st038134 10.228 µM -0.973914494792718 0.153610357355186 no 2870 0.165049498064571 4141 1272587 SGTC_2174 5790901 200 µM -0.975498664717564 0.153206486431813 no 2871 0.164656481859353 4082 786020 SGTC_904 1141-0088 396 µM -0.978502350761781 0.152442655320525 no 2872 0.163912964622902 4075 1378119 SGTC_1473 k844-0725 134 µM -0.978690578400056 0.15239487371955 no 2873 0.163866444358152 4115 54682906 SGTC_293 4049-0273 38.5 µM -0.982831433991901 0.151346231964557 no 2874 0.16284520413359 3933 1380311 SGTC_2142 5622915 118.518 µM -0.985029143362358 0.150791631904006 no 2875 0.162304877974484 4086 5322196 SGTC_3158 9100007 49.47 µM -0.985639777920261 0.150637776524777 no 2876 0.162154955527242 4099 19297233 SGTC_504 lovastatin 124 µM -0.986762542531481 0.150355157864263 no 2877 0.161879530784054 4091 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2534 helenine 20.12 µM -0.988462602504562 0.149927897204344 no 2878 0.161463070552395 4068 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2100 5377183 190 µM -0.993394894447986 0.148692895050363 no 2879 0.160258774348108 4097 2844202 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.99399765677268 0.148542436343588 no 2880 0.160112004120439 4140 5377381 SGTC_2881 9058953 51.95 µM -0.994879075583755 0.148322604037079 no 2881 0.159897540412817 4035 17122249 SGTC_540 1187-0821 17.3 µM -0.995025103567066 0.148286204613327 no 2882 0.159862027552037 4030 847520 SGTC_2427 5545055 42.75 µM -0.997858151269577 0.147581212208864 no 2883 0.159174073642426 4055 5372858 SGTC_2455 5377712 9.75 µM -0.997859242874897 0.147580941000757 no 2884 0.159173808940301 4078 2243908 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.998186324981568 0.14749969285809 no 2885 0.159094508160807 4030 16623 A steroid. SGTC_3094 9117742 49.47 µM -1.00168807043092 0.14663172712674 no 2886 0.158247135063768 4019 17149698 SGTC_3206 9114350 49.47 µM -1.0024760168743 0.146436894885518 no 2887 0.158056872053771 3995 17087243 SGTC_2029 5175081 200 µM -1.00334000361821 0.146223460319532 no 2888 0.157848420500786 4061 1380876 SGTC_2236 dapsone 200 µM -1.01002669901806 0.144578682906178 no 2889 0.156241249328404 4095 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1003 4049-0218 100 µM -1.01321272555322 0.143799392732488 no 2890 0.155479281698266 4139 295161 SGTC_2409 alverine citrate 63.97 µM -1.01328045449882 0.14378285730685 no 2891 0.155463110354282 4262 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1013 4112-3890 241 µM -1.01342748054961 0.1437469666066 no 2892 0.155428009406851 4052 705171 SGTC_222 nsc-310342 10.666 µM -1.01344061720264 0.143743760097168 no 2893 0.155424873421455 4107 432556 SGTC_2762 leflunomide 42.06 µM -1.0141375547376 0.143573714673261 no 2894 0.155258560164718 4067 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2694 st077685 81.9 µM -1.01587691870462 0.143149920655853 no 2895 0.154844000704605 4056 2838096 SGTC_2018 5133068 143 µM -1.01667940625572 0.142954680647574 no 2896 0.154652982801316 4060 785362 SGTC_1628 st004252 77.7 µM -1.01851680069448 0.142508332455383 no 2897 0.15421621037196 4139 692968 SGTC_368 fentichlor 4.58 µM -1.01905458508187 0.142377869934376 no 2898 0.154088526553961 4161 7329 A pesticide. SGTC_1478 0453-0656 35.7 µM -1.01985842544938 0.142183014883388 no 2899 0.153897804646273 4099 5258496 SGTC_2582 agaric acid 100 µM -1.01994166143294 0.142162848367742 no 2900 0.153878064722617 3844 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1217 1183-1422 255 µM -1.02240490465336 0.141566927024358 no 2901 0.153294650063874 4144 2849664 SGTC_50 0929-0078 56.389 µM -1.02270241817682 0.141495065638091 no 2902 0.153224283855537 3973 1377751 SGTC_1835 st008666 49.2 µM -1.02347899037744 0.141307608947607 no 2903 0.153040714272676 4056 690455 SGTC_2244 6635614 200 µM -1.02693829274259 0.140474614060816 no 2904 0.152224760802056 4043 836499 SGTC_500 h-89 112 µM -1.02865486650421 0.140062505687 no 2905 0.151820942853808 4146 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_696 1560-0013 611 µM -1.02951434289675 0.139856474840641 no 2906 0.151619021705811 4186 1650269 SGTC_186 3455-3465 67.277 µM -1.02959927617899 0.139836126104155 no 2907 0.151599077595281 4078 755278 SGTC_2440 5628896 157.78 µM -1.03058733892648 0.139599549020511 no 2908 0.151367187956522 4101 5522048 SGTC_629 3448-6466 76.7 µM -1.03170373301214 0.139332572560573 no 2909 0.151105464060565 4118 573744 SGTC_2681 menadione 3.18 µM -1.03269645781228 0.139095462562228 no 2910 0.150872985865307 4140 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2301 7769476 200 µM -1.0416753573076 0.13696335042878 no 2911 0.148781108880054 4159 977820 SGTC_81 0411-0046 9.971 µM -1.04287220604141 0.136680845053877 no 2912 0.148503741896298 4075 12925265 SGTC_956 1185-0240 191 µM -1.04369520697863 0.136486814421521 no 2913 0.148313214049249 4118 1416193 SGTC_2280 7785178 200 µM -1.04397776136076 0.136420242888652 no 2914 0.148247839358011 4129 2954328 SGTC_1288 0973-0013 65.5 µM -1.04406929572428 0.136398681599342 no 2915 0.148226665160073 4170 4315430 SGTC_1518 st038567 90.8 µM -1.04621655632703 0.135893554407703 no 2916 0.147730530299004 4089 77966 SGTC_2328 6201408 200 µM -1.04680702317739 0.135754876271699 no 2917 0.147594295276499 4143 2890418 SGTC_3026 9090633 49.47 µM -1.04757417100438 0.135574847330963 no 2918 0.147417421400667 4138 25236842 SGTC_3074 9116018 49.47 µM -1.04809949904259 0.135451661381009 no 2919 0.147296383544969 4194 17027303 SGTC_881 0833-0569 170 µM -1.04838583731774 0.135384549257941 no 2920 0.147230438020554 4152 5418700 SGTC_2477 5967686 25.23 µM -1.04880427322541 0.135286517010865 no 2921 0.147134105168542 4136 776118 SGTC_1775 st081588 35.1725 µM -1.05053329200075 0.13488195404365 no 2922 0.146736496392302 4140 1426443 YGL099W LSG1 SGTC_2446 5162541 200 µM -1.05091973695672 0.134791645649819 no 2923 0.146647727364374 4109 1549321 SGTC_40 0327-0103 19.753 µM -1.05164288602402 0.13462276428358 no 2924 0.146481711948477 4002 409036 SGTC_1930 st074634 34.3 µM -1.05202676568334 0.134533173582176 no 2925 0.146393634869085 4052 684253 YOR116C RPO31 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.05256174319543 0.134408387598857 no 2926 0.14627094931862 4175 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1728 st035614 33.7865 µM -1.05257803498927 0.134404588709813 no 2927 0.146267214230855 4107 15945546 SGTC_1668 st014914 51.6 µM -1.05449295041426 0.133958585945298 no 2928 0.145828643236022 4147 2839556 SGTC_1461 k072-0203 53.8 µM -1.05522557491157 0.133788219733259 no 2929 0.145661085040655 4050 5418714 SGTC_2387 9077560 195.08 µM -1.05604873443767 0.133596978046435 no 2930 0.145472975099434 4145 5303272 SGTC_1777 st045864 34.765 µM -1.05696400673581 0.133384556936691 no 2931 0.145264007287566 4131 4691462 SGTC_2033 5192550 145 µM -1.05831306361817 0.13307188467585 no 2932 0.144956369566035 4158 182073 SGTC_550 4123-0385 25.7 µM -1.06245326626942 0.132115457319916 no 2933 0.144014981603041 4177 5731123 SGTC_3126 9127922 49.47 µM -1.06345884942385 0.131883874961482 no 2934 0.143786958583402 4212 45595682 SGTC_1080 nisoldipine 24.4 µM -1.0639107955368 0.131779884578767 no 2935 0.14368455602254 4159 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1263 0774-1208 64.8 µM -1.06391724294579 0.131778401473854 no 2936 0.143683095516046 4213 906585 SGTC_331 k048-0133 24.5 µM -1.06569729750003 0.131369373913221 no 2937 0.143280249854657 4121 6813582 SGTC_3035 9091303 49.47 µM -1.06646246458318 0.131193820647618 no 2938 0.143107318878511 4218 25237002 SGTC_2765 myclobutanil 7.74 µM -1.06672343180454 0.131133983675455 no 2939 0.143048371449124 4192 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1772 st048439 82.2 µM -1.06866013577073 0.130690507408485 no 2940 0.142611420284801 4218 2927068 YDL195W SEC31 SGTC_2111 5486399 200 µM -1.07001349200759 0.13038122513933 no 2941 0.142306617867502 4138 689674 SGTC_229 benomyl 22.8748 µM -1.07132151548229 0.130082784239924 no 2942 0.142012444433697 4178 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2234 tolnaftate 200 µM -1.07260653364953 0.129790052984054 no 2943 0.141723846012077 4202 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2232 chlorophetanol 41.5365 µM -1.0809949190891 0.127890360568726 no 2944 0.139849686880714 4243 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.08184635318161 0.127698624534956 no 2945 0.139660402930205 4145 6857784 SGTC_1286 0929-0070 131 µM -1.08215475606009 0.127629224035076 no 2946 0.139591884289001 4245 1420408 SGTC_1949 st076024 69.1 µM -1.08398781279968 0.127217268808539 no 2947 0.139185101241988 4103 2921930 SGTC_1218 1348-1416 30.7 µM -1.08655577765482 0.126641709903962 no 2948 0.138616588878837 4124 6787668 SGTC_3141 9094609 49.47 µM -1.08782589063216 0.126357710323225 no 2949 0.138335988741213 4142 25236309 YDL196W YDL196W SGTC_2003 4023581 200 µM -1.08983861515694 0.125908570842535 no 2950 0.137892120293842 4223 16641307 SGTC_2425 5628681 7.85 µM -1.09181782362424 0.125467997326227 no 2951 0.137456591602522 4254 5714958 SGTC_2903 5923464 63.88 µM -1.09217888061791 0.125387741912704 no 2952 0.137377241710167 4185 2876576 SGTC_719 2810-4230 27.3 µM -1.09338823406114 0.125119189001731 no 2953 0.137111688647957 4185 721079 SGTC_2593 nobiletin 86.24 µM -1.09406665528935 0.124968712602849 no 2954 0.136962872746025 4189 72344 An anti-infammatory. SGTC_3003 9075612 71.4286 µM -1.09632991809856 0.124467626889316 no 2955 0.136467210550264 4214 6501993 SGTC_2869 9037858 32.47 µM -1.09725535631236 0.124263140342393 no 2956 0.136264890308058 4145 27187042 SGTC_2686 alizarin 95.37 µM -1.09735544922824 0.124241037715806 no 2957 0.136243020199317 4187 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1557 sumaresinolic acid 42.3 µM -1.0973840435456 0.124234723992579 no 2958 0.136236772837339 4162 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2788 5282734 71.43 µM -1.09744456450531 0.124221361497575 no 2959 0.136223550704761 4280 743706 SGTC_2942 9052777 62.25 µM -1.09756085968367 0.12419568736834 no 2960 0.136198145934412 4261 6469503 SGTC_531 3788-1495 174 µM -1.09812600504435 0.124070974813993 no 2961 0.136074735663322 4160 2896655 SGTC_2414 st077232 92.9 µM -1.09889716886964 0.123900940862676 no 2962 0.135906460847105 4131 729801 SGTC_2728 chlorpromazine 9.18 µM -1.10042931212598 0.12356360259881 no 2963 0.135572556448159 4251 2726 A thorazine and dopamine antagonist. SGTC_1986 st071812 45 µM -1.10096675466973 0.123445424199243 no 2964 0.135455563314324 4140 11838594 SGTC_2061 5245884 80.95 µM -1.10114450396369 0.123406356283247 no 2965 0.135416885204041 4165 573863 SGTC_3196 9111891 49.47 µM -1.10253521646597 0.123100987448142 no 2966 0.135114528508453 4189 18891510 SGTC_1748 st037455 53.6035 µM -1.10686590123608 0.122153461655177 no 2967 0.13417595523256 4252 580690 SGTC_3301 9125354 19.7965 µM -1.10892568020662 0.121704596920062 no 2968 0.133731122234875 4182 41905162 SGTC_1060 3448-7350 82 µM -1.11023703656656 0.121419432148685 no 2969 0.133448448498454 4153 570178 SGTC_3112 9123419 49.47 µM -1.11179915736743 0.121080350173732 no 2970 0.133112257129112 4257 17015854 SGTC_2376 9072922 81.32 µM -1.11225885978426 0.120980691787005 no 2971 0.133013433516414 4215 17087968 SGTC_144 4161-2749 112.381 µM -1.11348944239692 0.120714199201264 no 2972 0.132749140063784 4156 797501 YMR168C CEP3 SGTC_1644 st010134 20.9 µM -1.11381228236845 0.120644354080079 no 2973 0.132679863331074 4183 3818134 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.11457871628294 0.12047865316858 no 2974 0.132515497578261 4268 1609 A potent and irreversible inhibitor of serine proteases. SGTC_347 4534-1311 26.2 µM -1.11542042733112 0.120296862281339 no 2975 0.132335149954135 4220 2862016 SGTC_1914 st062367 72.6 µM -1.11621331032691 0.120125793999557 no 2976 0.132165419180825 4204 978205 SGTC_2359 9039622 200 µM -1.11733522468444 0.119884028645204 no 2977 0.131925509901166 4164 6463596 SGTC_1564 D-Arginine 115 µM -1.11917007412944 0.119489370001271 no 2978 0.131533794828999 4231 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_543 3844-1095 191 µM -1.11930393450483 0.119460613825123 no 2979 0.131505248937705 4207 4230703 SGTC_2665 lovastatin 100 µM -1.12071572244365 0.119157627755011 no 2980 0.131204443791061 4219 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1337 1486-1011 40.3 µM -1.12241587111068 0.118793476622368 no 2981 0.130842829714241 4183 X1337 SGTC_1228 0124-0032 52.5 µM -1.1244731470457 0.118353885208614 no 2982 0.130406178056398 4288 X1228 SGTC_166 k072-0058 166.424 µM -1.12973876037675 0.11723398970477 no 2983 0.12929315977819 4119 5846229 SGTC_3340 9146634 11.102 µM -1.13076351259628 0.117016919880722 no 2984 0.129077320556072 4238 4907387 SGTC_3317 9138495 8.753 µM -1.13174899810839 0.116808436590626 no 2985 0.128869987690931 4128 17020139 SGTC_1123 mangostin 811.285 nM -1.13249629837279 0.116650517953744 no 2986 0.128712919869962 4223 5281650 An antioxidant. SGTC_2007 4011539 71.82 µM -1.13376805093933 0.116382120804971 no 2987 0.128445927942122 4171 45595301 SGTC_1556 plumbagin 1.48 µM -1.13396394259207 0.116340817801203 no 2988 0.128404836612869 4145 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1594 piperine 70.1 µM -1.13446568126031 0.116235075560678 no 2989 0.128299630726485 4196 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2934 9036370 36.88 µM -1.13714244795768 0.115672095092035 no 2990 0.127739370701807 4210 6462800 SGTC_2120 5538279 151.968 µM -1.13718289680552 0.115663602728035 no 2991 0.127730917627873 4192 2058197 SGTC_1440 4100-1550 40 µM -1.13875032231064 0.115334857813641 no 2992 0.127403653609262 4229 742806 SGTC_814 3342-0569 96 µM -1.13996987667256 0.115079533637422 no 2993 0.127149425594308 4295 4346283 SGTC_3268 9137683 49.47 µM -1.14226781465863 0.114599533276015 no 2994 0.126671357635651 4304 1953228 SGTC_2854 9024559 71.43 µM -1.14326842561134 0.114390968494486 no 2995 0.126463580085602 4264 3163529 SGTC_2194 5927483 104.545 µM -1.14411794566723 0.114214108938775 no 2996 0.126287363123597 4270 760979 SGTC_1166 k206-0078 225 µM -1.14458306048469 0.114117360331565 no 2997 0.126190956324708 4256 5404595 SGTC_3243 9134147 49.47 µM -1.14502734021018 0.114025000160101 no 2998 0.126098916038718 4333 24282180 SGTC_3239 9133757 49.47 µM -1.14528197491134 0.113972088819584 no 2999 0.126046185126858 4268 17036923 SGTC_2684 capsaicin 100 µM -1.14535152958085 0.113957638879659 no 3000 0.126031784103214 4257 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2291 7917025 104.35 µM -1.14576031733871 0.113872739853252 no 3001 0.125947169372448 4145 2964612 SGTC_1000 4048-0884 8.67 µM -1.14660377905346 0.113697708094113 no 3002 0.125772706955169 4285 13040088 SGTC_2197 6588183 93.1375 µM -1.14734076631647 0.113544928545647 no 3003 0.125620405869768 4190 884136 SGTC_1653 st012112 65 µM -1.15113713358735 0.112760249867637 no 3004 0.12483791168992 4226 720429 SGTC_1477 0139-0234 16 µM -1.15542888366275 0.111877851161976 no 3005 0.123957419777366 4245 620880 SGTC_2026 5148700 152 µM -1.15965570988182 0.111013638480507 no 3006 0.12309450466483 4221 79838 SGTC_2465 5809242 33.21 µM -1.16238539736375 0.110458076373336 no 3007 0.122539476079231 4296 2731748 SGTC_2712 st079126 47.7 µM -1.16252019875384 0.110430692539678 no 3008 0.12251211242284 4236 3152970 SGTC_1441 4106-0040 13 µM -1.16254771766366 0.110425102889616 no 3009 0.122506526820574 4253 2904180 SGTC_2459 5811157 9.22 µM -1.16423395937051 0.110082979872354 no 3010 0.122164605765769 4223 2870684 YBR192W RIM2 SGTC_1874 staurosporine 7.6 µM -1.16930595460711 0.109058503743464 no 3011 0.121140192458226 4265 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_783 0848-0141 92.7 µM -1.17042356163946 0.108833686135895 no 3012 0.120915279199721 4177 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2358 9037157 4 µM -1.17089239797255 0.108739474391852 no 3013 0.120821015595767 4263 2388925 SGTC_340 k038-0059 454 µM -1.17326280802216 0.10826404292596 no 3014 0.120345215958049 4221 23733424 SGTC_3016 9080866 49.47 µM -1.17423887900511 0.108068708540116 no 3015 0.120149678634859 4234 17066299 SGTC_1146 3579-1023 7 µM -1.1774515188349 0.107427577253841 no 3016 0.119507668608813 4293 X1146 SGTC_1485 3909-9022 254 µM -1.17874118960942 0.107170976470038 no 3017 0.119250624362429 4327 714516 SGTC_1650 st011916 45.8 µM -1.17929582670256 0.107060758499136 no 3018 0.119140199737137 4198 242528 SGTC_3296 9122258 64.045 µM -1.18190782445216 0.106542799058461 no 3019 0.118621138497161 4244 4730474 SGTC_2110 5483698 200 µM -1.1825896838285 0.106407884520291 no 3020 0.118485901488386 4252 2848765 YHR062C RPP1 SGTC_2105 5350118 200 µM -1.18346282331872 0.106235302963072 no 3021 0.118312885977834 4237 2133313 SGTC_1963 st076565 50.3 µM -1.1845930420211 0.106012208421223 no 3022 0.118089194706006 4289 4914280 SGTC_2732 terfenadine 20 µM -1.18667978664802 0.105601194555943 no 3023 0.117676975515866 4338 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1386 3228-0095 33.8 µM -1.18746694932756 0.105446451430712 no 3024 0.117521742887129 4291 870181 SGTC_1476 4112-3294 3.34 µM -1.19308859276311 0.104346095928438 no 3025 0.116417339269334 4274 704369 SGTC_2098 5376439 882.5 nM -1.19356518175459 0.10425319458048 no 3026 0.116324050343444 4314 2844116 SGTC_1695 st026914 34.495 µM -1.19745345541656 0.103497493620146 no 3027 0.115564929467777 4273 3289191 SGTC_1511 0906-3109 28.5 µM -1.20000135172088 0.103004461098102 no 3028 0.115069407736576 4289 2882180 SGTC_3134 9127454 49.47 µM -1.2009892511832 0.102813756610674 no 3029 0.114877685443625 4339 24262820 SGTC_1587 estradiol valerate 56.1 µM -1.20139063280448 0.102736347090726 no 3030 0.114799854002263 4334 13791 A steroid. SGTC_1680 diphenhydramine 100 µM -1.20194999860922 0.102628539768388 no 3031 0.114691450613605 4263 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1439 4092-1168 46 µM -1.20657020953648 0.101741223661985 no 3032 0.113798852618193 4290 2886240 SGTC_1084 voriconazole 435 nM -1.20721173170061 0.101618461626724 no 3033 0.113675306773277 4300 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2791 5663188 71.43 µM -1.20797065916583 0.101473372167922 no 3034 0.113529274238659 4326 54690634 SGTC_193 1273-0060 1.558 µM -1.20840850371527 0.101389735035573 no 3035 0.11344508522989 4130 2847393 YHR072W ERG7 SGTC_686 1319-0111 510 µM -1.20961296577921 0.101159917610382 no 3036 0.113213720277887 4340 4562600 SGTC_2706 st078239 82.5 µM -1.20976078822628 0.101131738518764 no 3037 0.113185348294193 4269 15434492 SGTC_3349 9149703 23.001 µM -1.21004274857326 0.101078004856292 no 3038 0.113131244908217 4306 4910494 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.21167538959343 0.10076727872797 no 3039 0.112818331683007 4309 66535 A nucleotide analog. SGTC_2072 5231554 129 µM -1.21184365200797 0.100735294469253 no 3040 0.112786117537701 4333 789545 SGTC_1103 duloxetine 36.1 µM -1.21336688015407 0.100446087600737 no 3041 0.112494791545363 4379 60835 A selective serotonin reuptake inhibitor. SGTC_124 0136-0217 7.121 µM -1.21475978669371 0.10018215490582 no 3042 0.112228861178716 4339 3976905 SGTC_2461 5755302 26.15 µM -1.21530457294308 0.100079064788656 no 3043 0.112124974218353 4327 2788904 SGTC_1735 st034310 56.75 µM -1.21910167424378 0.0993626884175164 no 3044 0.111402802264997 4351 871153 SGTC_2718 lomofungin 53.02 µM -1.21923097904958 0.0993383594281616 no 3045 0.111378268492097 4276 5351222 A RNA synthesis inhibitor. SGTC_1902 st060212 70.5 µM -1.22192955190768 0.0988316103500015 no 3046 0.110867134452428 4304 688944 SGTC_947 3447-0010 211 µM -1.22285752371004 0.0986577898085356 no 3047 0.11069175711775 4266 748350 SGTC_1015 4130-4525 82 µM -1.2228877117353 0.0986521389802368 no 3048 0.110686055225584 4302 1363237 SGTC_2419 paclitaxel 166.5 µM -1.2262126315311 0.098031203886143 no 3049 0.110059334538208 4231 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3051 9093778 49.47 µM -1.22811395319734 0.0976774180129113 no 3050 0.109702096902321 4382 17217378 SGTC_1494 4358-1428 177 µM -1.22900465295996 0.0975120046196613 no 3051 0.109535030741428 4326 1564571 SGTC_18 0111-0177 500 nM -1.23132728973886 0.0970816302703907 no 3052 0.109100239598081 4386 721752 SGTC_454 lyso-paf C-16 6.67 µM -1.23145082058626 0.0970587796578691 no 3053 0.109077149754109 4334 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1205 4161-2785 76 µM -1.23145506465144 0.0970579946650911 no 3054 0.109076356534475 4345 3498106 SGTC_2453 5731132 22.18 µM -1.2328753621431 0.0967955545919766 no 3055 0.10881113443568 4357 1362040 SGTC_2315 7733312 200 µM -1.23393318838418 0.0966004301736926 no 3056 0.108613900640326 4216 726316 SGTC_2001 4023502 57.655 µM -1.23740824290893 0.0959614627197358 no 3057 0.107967780073965 4333 108941 YCR052W RSC6 SGTC_1424 4048-1941 275 µM -1.23942538093117 0.0955919948395708 no 3058 0.107594003425526 4393 X1424 SGTC_2251 lansoprazole 556 µM -1.24083695389532 0.0953340682074715 no 3059 0.107332993406345 4261 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2444 5485484 36.41 µM -1.2448896486082 0.0945963959887937 no 3060 0.106586158204987 4393 6790631 SGTC_2909 7941780 10.49 µM -1.24542391554907 0.0944994633917959 no 3061 0.106487983423895 4298 1243215 SGTC_1357 1503-1303 39.5 µM -1.24625166599776 0.0943494284338122 no 3062 0.106336008231351 4304 292895 SGTC_1506 4226-2149 212 µM -1.24695160609688 0.0942226970416107 no 3063 0.106207621324139 4333 991114 SGTC_642 0335-0876 158 µM -1.24863768902373 0.0939179299252653 no 3064 0.10589881042445 4368 6812350 SGTC_214 4373-3496 70 µM -1.25024540669197 0.0936280058657847 no 3065 0.105604957233728 4424 3779166 SGTC_318 1488-0629 67.2 µM -1.25140088611544 0.0934200436790076 no 3066 0.105394127080461 4373 3662576 SGTC_420 mitomycin C 81.9 mM -1.2523232971308 0.0932542740046213 no 3067 0.10522604153489 4313 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2441 5730946 39.09 µM -1.25384883860445 0.0929805908020037 no 3068 0.10494847688849 4384 1774275 SGTC_2572 astragaloside iv 100 µM -1.25898659835382 0.0920632403434445 no 3069 0.104017586273412 4355 45006101 An anti-inflammatory agent. SGTC_371 0195-0006 7.36 µM -1.26122459899651 0.0916657457416671 no 3070 0.10361396915349 4173 3928593 SGTC_150 3970-0969 77.2 µM -1.26260560454441 0.0914210985593317 no 3071 0.1033654763656 4403 6615640 SGTC_613 3914-0030 117 µM -1.26264790066283 0.0914136133850977 no 3072 0.10335787259978 4047 1145395 SGTC_317 4495-0002 170 µM -1.26364012389279 0.091238149237594 no 3073 0.103179612591434 4362 15991618 SGTC_483 fpl-64176 144 µM -1.26651948524943 0.0907303787165736 no 3074 0.102663578921266 4460 3423 SGTC_3079 9117512 49.47 µM -1.26971394327442 0.0901694987957066 no 3075 0.102093272130728 4413 7185044 SGTC_1867 st057372 64 µM -1.27006381766133 0.0901082250251321 no 3076 0.102030949364935 4301 688837 SGTC_227 fluconazole 33.516 µM -1.27015416288151 0.0900924078236339 no 3077 0.102014860761573 4337 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_547 1120-0019 610 nM -1.27045136266407 0.0900403900861241 no 3078 0.101961948690698 4296 3676939 SGTC_2939 9044578 71.43 µM -1.27250971126982 0.0896807375786956 no 3079 0.10159603792639 4279 2653634 SGTC_890 0929-0006 47.2 µM -1.27760388758168 0.0887952333325074 no 3080 0.100694564568464 4339 1378169 SGTC_675 1309-0189 238 µM -1.28098096450625 0.0882118060321884 no 3081 0.100100176147668 4349 4246530 SGTC_2726 cimetidine 79.27 µM -1.28241670631604 0.0879646332368497 no 3082 0.0998482533946431 4333 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_313 3474-0040 5.03 µM -1.28291312777782 0.0878792911477751 no 3083 0.0997612565268216 4364 1043375 YIL048W NEO1 SGTC_1093 fluphenazine 7.97 µM -1.28548279771164 0.087438514346344 no 3084 0.0993118121144194 4385 6602611 An atypical antipsychotic. SGTC_2203 7227154 166.4 µM -1.28761621784894 0.0870738231049288 no 3085 0.0989397955273119 4378 896304 SGTC_2442 5158906 48.48 µM -1.28813628179088 0.0869850947632471 no 3086 0.0988492637765718 4365 1893835 SGTC_2610 ononetin 44.17 µM -1.28827844603814 0.0869608518158063 no 3087 0.0988245266449054 4331 259632 SGTC_1502 4534-4282 27.7 µM -1.28961198165861 0.0867336926761578 no 3088 0.0985927067653424 4319 3278949 SGTC_2263 7948595 193.29 µM -1.29339422148193 0.0860918253507217 no 3089 0.0979373738375253 4368 2971371 SGTC_2673 kobusone 100 µM -1.29406583628188 0.0859782210516997 no 3090 0.0978213404761937 4460 6710676 An epoxy ketone and protein crosslinker. SGTC_3335 9143315 29.6265 µM -1.29609967772776 0.085634878996282 no 3091 0.0974705730040285 4359 4899691 SGTC_859 0439-0102 54.6 µM -1.29778197610658 0.0853516591207513 no 3092 0.0971811324276466 4385 610143 SGTC_659 k018-0002 107 µM -1.29887176380195 0.0851685650183297 no 3093 0.0969939706523382 4336 6797879 YHR007C ERG11 SGTC_975 1335-0046 28.5 µM -1.30251997724732 0.0845577741201979 no 3094 0.0963693466725326 4374 16486740 SGTC_2792 7535235 81.82 µM -1.30605712397309 0.0839687212273787 no 3095 0.0957665661273468 4351 1281891 SGTC_94 0334-0113 514.748 µM -1.31566715613001 0.082383893273973 no 3096 0.0941428912466205 4378 6795178 SGTC_1223 0764-0573 147 µM -1.31756139495365 0.0820741816570606 no 3097 0.0938252580136176 4372 1609797 SGTC_475 α-linolenic acid 10 µM -1.3197486770251 0.081717649068448 no 3098 0.0934594710669779 4387 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1065 prochlorperazine maleate 2.48 µM -1.32009536302904 0.0816612457169512 no 3099 0.0934015903734689 4411 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3092 9117248 49.47 µM -1.32171177731381 0.0813986539787707 no 3100 0.0931320726917361 4504 17141857 SGTC_2815 7968870 71.43 µM -1.32283984050599 0.0812157741339893 no 3101 0.0929443225020446 4328 2977326 YHR190W ERG9 SGTC_1643 st009866 20.2 µM -1.32682419953736 0.0805723168931751 no 3102 0.0922834216982804 4353 3156273 YOR207C RET1 SGTC_361 000s-0510 1.45 µM -1.32683802667482 0.0805700905930823 no 3103 0.0922811342104244 4297 660 SGTC_1111 tnp00062 510.699 nM -1.32793507306067 0.0803936037846745 no 3104 0.0920997784331482 4410 676306 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.32902769666119 0.0802181189802557 no 3105 0.0919194162124721 4448 279621 SGTC_2961 9083290 32.55 µM -1.32980945413041 0.080092739750445 no 3106 0.0917905301003297 4322 17741490 SGTC_665 3914-0008 307 µM -1.33035206336586 0.0800058025461679 no 3107 0.0917011504094816 4355 1069549 SGTC_1231 0242-0792 125 µM -1.33375188733908 0.0794627038891119 no 3108 0.0911425918055756 4393 3707635 SGTC_2258 7960471 200 µM -1.33468177984536 0.0793146469413938 no 3109 0.0909902596744549 4393 2974708 SGTC_3172 9105863 49.47 µM -1.33559391983451 0.0791696195175977 no 3110 0.0908410192742367 4478 2348785 SGTC_1038 k292-0204 154 µM -1.33718639264079 0.078916902714362 no 3111 0.0905809012321075 4339 4454212 SGTC_1747 st037496 66.6 µM -1.34124705389701 0.0782752639618888 no 3112 0.0899201268811314 4356 723305 SGTC_2102 5377816 72.7585 µM -1.34346829421756 0.0779259563795161 no 3113 0.0895601929136697 4449 1379702 SGTC_3285 9112818 20.8695 µM -1.34393755086126 0.0778523136384484 no 3114 0.0894842909515341 4367 17017947 YPR165W RHO1 SGTC_1581 himbacine 57.9 µM -1.3479588192419 0.0772234004666889 no 3115 0.0888358140371685 4405 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2971 9092186 9.93 µM -1.34837479954322 0.0771585634481047 no 3116 0.0887689325298451 4365 25236400 SGTC_1849 st056239 19.2 µM -1.35386350776422 0.0763069319010603 no 3117 0.087889963881674 4396 5393181 SGTC_2727 riluzole 51.77 µM -1.35749043397755 0.0757481130014906 no 3118 0.0873127154699872 4446 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2307 7538926 6.34 µM -1.36362597704001 0.0748098834495115 no 3119 0.0863426560197931 4387 96582 SGTC_2992 9074591 71.4286 µM -1.3647307986975 0.0746418833861331 no 3120 0.0861688379148384 4361 17741321 SGTC_47 0149-0135 24.25 µM -1.36573440958847 0.0744895232254344 no 3121 0.0860111699808653 4424 5239155 SGTC_2317 5986382 200 µM -1.36595526378267 0.0744560268050102 no 3122 0.0859765026372155 4432 877883 SGTC_148 3253-0744 288.01 µM -1.36633699691544 0.0743981573824529 no 3123 0.0859166068838936 4289 6893655 SGTC_2124 5246320 200 µM -1.36973526922385 0.0738845036996891 no 3124 0.0853847774141667 4424 579342 SGTC_2729 fluphenazine 10.66 µM -1.37972192227311 0.0723906887465359 no 3125 0.083836140219186 4362 3372 An atypical antipsychotic. SGTC_2240 6690706 185.951 µM -1.38160141652874 0.0721121573634687 no 3126 0.0835470594046274 4314 805876 SGTC_2813 7971799 71.43 µM -1.38207909480985 0.0720414989935914 no 3127 0.0834737082912703 4429 2234054 SGTC_1104 tacrolimus 29.8 µM -1.38889134318981 0.0710395955238902 no 3128 0.0824328966603841 4498 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.38929758934356 0.070980187162436 no 3129 0.0823711383207618 4421 688751 SGTC_2379 9035213 200 µM -1.39243751335543 0.0705222995166079 no 3130 0.0818949756902781 4429 646551 SGTC_2753 fluvastatin 17.09 µM -1.39379672544746 0.0703247944399878 no 3131 0.0816894986396795 4424 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_88 0180-0332 8.668 µM -1.40023865182772 0.0693945080802075 no 3132 0.0807209324694884 4533 3101745 SGTC_2484 5809818 12.04 µM -1.40238004671305 0.0690873747588007 no 3133 0.0804008942527437 4416 2870548 SGTC_3276 9139060 49.47 µM -1.42490363718536 0.0659200313652328 no 3134 0.0770925290647567 4542 4870619 SGTC_3161 9100388 49.47 µM -1.42760052202623 0.0655484544877026 no 3135 0.0767034366419465 4523 25236368 SGTC_1807 st050092 58.9 µM -1.43091290636701 0.0650942989445802 no 3136 0.0762275888112707 4470 5008496 SGTC_1632 st005650 90 µM -1.43194059682978 0.0649538914776967 no 3137 0.0760804112828011 4467 2759605 SGTC_3110 9122132 49.47 µM -1.4326231717855 0.0648607651717113 no 3138 0.0759827780304802 4483 918317 SGTC_591 4299-0174 154 µM -1.43323744863397 0.0647770456890165 no 3139 0.075894995495188 4487 5509088 SGTC_923 1900-2434 73.3 µM -1.43396319487799 0.0646782422569707 no 3140 0.0757913830990741 4434 5910570 SGTC_2405 ticlatone 3.52 µM -1.43563460270262 0.0644511412003372 no 3141 0.0755531715336706 4258 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1943 st076331 65.2 µM -1.43946131140158 0.0639335238240669 no 3142 0.0750099319644077 4448 24208415 SGTC_966 1300-0360 30.2 µM -1.44184157815446 0.0636131929714386 no 3143 0.0746735352135643 4455 70588 SGTC_3109 9122853 49.47 µM -1.44410761743466 0.063309396296037 no 3144 0.0743543528444561 4477 1234709 SGTC_190 3970-0790 3.722 µM -1.44427435921359 0.0632870867411269 no 3145 0.0743309076852176 4425 2832352 SGTC_405 ebelactone b 50 µM -1.44490158940018 0.0632032200175602 no 3146 0.0742427649163046 4407 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1483 3453-0561 55.9 µM -1.4469237205912 0.06293343071914 no 3147 0.0739591443731922 4492 4546991 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.45304419779289 0.0621223124023896 no 3148 0.0731057414524805 4545 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2962 9082311 13.18 µM -1.47018005447444 0.0598947301584096 no 3149 0.0707564975904236 4445 16459453 SGTC_2480 5767542 37.17 µM -1.47321839689947 0.0595063714675181 no 3150 0.0703460780111178 4403 2867358 SGTC_1870 st057514 26.5 µM -1.47365712845899 0.0594504565685932 no 3151 0.0702869656652658 4481 5393161 SGTC_1250 0485-0349 40.2 µM -1.47541433312891 0.0592269193131419 no 3152 0.0700505921189939 4470 6842794 YDL195W SEC31 SGTC_1401 3807-4679 7.6 µM -1.48040268143047 0.0585959328016147 no 3153 0.0693829074237995 4413 3291456 SGTC_1133 3473-0247 50 µM -1.4814715213349 0.0584614220573359 no 3154 0.0692404841660856 4452 711311 SGTC_2714 st079313 56.9 µM -1.48174655268375 0.0584268493251441 no 3155 0.0692038726115503 4472 2939799 SGTC_599 1935-0052 86.5 µM -1.48208003112255 0.0583849510584844 no 3156 0.0691595007206112 4479 9557311 SGTC_2904 7225135 42.03 µM -1.48480212786143 0.0580438284096511 no 3157 0.0687981240434006 4548 4446116 SGTC_2368 9071271 200 µM -1.48754043713911 0.0577022563171994 no 3158 0.0684360657389207 4461 27209959 SGTC_1202 1988-0068 29.6 µM -1.48899080371314 0.0575219814064512 no 3159 0.0682448951991687 4459 2850480 SGTC_2091 4-phenylthiadiazole 200 µM -1.49308399503772 0.0570156025588997 no 3160 0.0677076007443284 4505 270010 SGTC_677 0929-0063 136 µM -1.49711861449154 0.056519910962476 no 3161 0.0671811985156332 4521 1539583 SGTC_2617 dihydrotanshinone i 20.83 µM -1.49736837477187 0.0564893374928654 no 3162 0.0671487162584289 4441 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1901 st060216 58.6 µM -1.50115896382047 0.0560269248687502 no 3163 0.0666572254950998 4455 688792 SGTC_3083 9117465 49.47 µM -1.50305318504779 0.0557969708618747 no 3164 0.0664126648301829 4448 16420915 SGTC_3032 9089427 49.47 µM -1.50833805303818 0.0551593363700498 no 3165 0.0657340143674306 4479 17173707 SGTC_2931 9014674 55.67 µM -1.51217003948631 0.0547006067060904 no 3166 0.0652453053720124 4454 2996810 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.51532659346733 0.0543250035693516 no 3167 0.0648448584536388 4484 6708760 SGTC_909 3448-9333 149 µM -1.51539854077995 0.0543164662935234 no 3168 0.0648357533627616 4431 3344074 SGTC_1108 betulinic acid 729.144 nM -1.51796407852878 0.0540127324835097 no 3169 0.0645117272491283 4502 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2070 5230947 200 µM -1.52052671722101 0.0537106856678647 no 3170 0.064189324582741 4584 2835538 SGTC_2618 avocadyne 43.43 µM -1.52211565783639 0.0535240772311025 no 3171 0.0639900516670553 4434 3015189 SGTC_2677 mitomycin C 100 µM -1.52243112015777 0.0534870898777953 no 3172 0.0639505460610277 4584 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2908 7930301 100 µM -1.52402267046816 0.0533007923865371 no 3173 0.0637515240599116 4468 2223178 SGTC_757 1066-0008 322 µM -1.52836881658172 0.0527946773457756 no 3174 0.0632104963108478 4531 6842497 SGTC_45 0kpi-0036 14.9 µM -1.52842032398952 0.0527887021737227 no 3175 0.0632041059411415 4479 2795021 SGTC_320 4092-0846 5.34 µM -1.52970404458512 0.0526399560321255 no 3176 0.0630450010252703 4480 1359356 SGTC_924 2046-0044 21.3 µM -1.53179947254295 0.0523978712289397 no 3177 0.0627859631398722 4491 3623589 SGTC_3311 9131146 2.8755 µM -1.53193804740397 0.0523818928856074 no 3178 0.0627688617248255 4453 4900406 YPR165W RHO1 SGTC_2963 9082507 9 µM -1.53418777803582 0.0521230290254219 no 3179 0.0624917317627777 4516 16459611 SGTC_315 k915-0449 187 µM -1.53558104515528 0.0519632238039138 no 3180 0.062320582987042 4541 20970215 YNL149C PGA2 SGTC_2575 plumbagin 510 nM -1.54073264237542 0.0513757232205273 no 3181 0.0616909344256866 4440 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_753 1322-0200 289 µM -1.5412922748119 0.0513122208088473 no 3182 0.0616228341003308 4566 5403907 SGTC_1497 4476-2978 41.3 µM -1.54135307590693 0.0513053253707772 no 3183 0.0616154388978882 4553 1528379 SGTC_533 1222-0222 6.71 µM -1.54298533268858 0.0511204868794775 no 3184 0.0614171673475795 4531 3982874 SGTC_2495 cafestol 54.53 µM -1.54701906332053 0.0506659755663684 no 3185 0.0609293244352447 4506 16667697 An anti-infammatory. SGTC_2365 9042475 200 µM -1.55163677995991 0.0501496195383756 no 3186 0.0603745787218786 4557 6464479 SGTC_1696 st025591 34.7925 µM -1.5545752209276 0.0498232312432808 no 3187 0.0600236345041048 4522 2787147 SGTC_2118 5526350 200 µM -1.56075488097703 0.0491423529427085 no 3188 0.0592907984067848 4532 743594 SGTC_2835 9006588 71.43 µM -1.56747301271962 0.0484105982885329 no 3189 0.0585020847404516 4494 2345538 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.56774631040576 0.0483810155350268 no 3190 0.0584701746245527 4538 2346 DNA damaging agent; causes G2/M arrest. SGTC_1208 2323-2347 50.3 µM -1.56804509635434 0.048348690383593 no 3191 0.0584353041513928 4543 5412760 SGTC_574 1315-0397 40 µM -1.57105217266507 0.0480243208046289 no 3192 0.0580852653111284 4520 6794277 SGTC_1358 1509-0022 2.48 µM -1.57238527854914 0.0478810786557041 no 3193 0.0579306131537056 4559 3258434 SGTC_1981 st071826 47 µM -1.57264073532615 0.0478536689306649 no 3194 0.0579010148776747 4573 11838600 SGTC_2970 9090938 41.86 µM -1.57264419923092 0.0478532973506974 no 3195 0.057900613617079 4565 17217104 SGTC_1101 ebselen 5.29 µM -1.57344075575666 0.0477679104686645 no 3196 0.0578083981121887 4541 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_228 caffeine 993.056 µM -1.5790367781687 0.0471714788192601 no 3197 0.0571638107140023 4532 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_383 2324-0395 7.37 µM -1.58271756488813 0.0467824407227881 no 3198 0.0567429264922581 4519 3146421 SGTC_2145 5634607 200 µM -1.58369200490491 0.0466798800414108 no 3199 0.056631912550464 4545 308662 SGTC_2824 7998404 51.95 µM -1.58473571948219 0.0465702283290393 no 3200 0.0565131963122883 4517 837851 SGTC_2300 7976697 71.57 µM -1.59218276831554 0.0457938351202441 no 3201 0.0556718219461783 4436 2236109 SGTC_1642 st009582 77.7 µM -1.59482807371388 0.0455205652507099 no 3202 0.055375343668784 4529 6739311 SGTC_2656 pseudo-anisatin 100 µM -1.59687325848865 0.0453101901204857 no 3203 0.055146980894232 4602 6708809 A neurotoxin. SGTC_2117 5521686 200 µM -1.59689596635964 0.0453078587040136 no 3204 0.0551444495440271 4541 803312 SGTC_226 1,3-diallylurea 8.28947 mM -1.60220989778713 0.0447649255492379 no 3205 0.0545546010398005 4525 74537 YKL182W FAS1 SGTC_407 eburnamonine 100 µM -1.60532248210516 0.0444493485772399 no 3206 0.0542114269956142 4403 3195 SGTC_2302 7771753 200 µM -1.60612502823406 0.0443682718164757 no 3207 0.0541232208662049 4529 2203047 SGTC_885 0865-0106 16.8 µM -1.60702161871518 0.044277835263912 no 3208 0.0540248128946092 4513 2793380 SGTC_1574 spiramycin 23.7 µM -1.6093104890712 0.0440476370413666 no 3209 0.0537742333370565 4518 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2769 toremifene 3.73 µM -1.61016828834608 0.0439616147142993 no 3210 0.0536805611615136 4543 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_838 0109-0203 71.4 µM -1.6106670758886 0.0439116573383935 no 3211 0.0536261527281748 4577 759422 SGTC_1669 st015249 58.4 µM -1.61422009237955 0.0435571190762474 no 3212 0.0532398476598377 4669 722793 SGTC_1840 st055363 71 µM -1.61652705593896 0.0433281579764053 no 3213 0.0529902042861884 4579 676033 SGTC_2386 9075165 157.42 µM -1.61842376121771 0.0431406429118782 no 3214 0.0527856523404758 4529 16452277 SGTC_2733 amorolfine 100 µM -1.62213755276103 0.0427753826554142 no 3215 0.05238694952732 4712 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_873 0591-4978 488 µM -1.62357307753128 0.0426348669444803 no 3216 0.0522334775986767 4572 3305145 SGTC_2990 9074105 71.4286 µM -1.63269778598131 0.0417504022617837 no 3217 0.0512662866616329 4501 6502001 SGTC_1596 piperlongumine 63 µM -1.6328116820062 0.0417394568609892 no 3218 0.0512543046867565 4569 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1376 2910-0861 41.3 µM -1.63435927415983 0.0415909635530829 no 3219 0.0510917171687735 4492 1112859 SGTC_2122 5258151 111.688 µM -1.63513129073935 0.0415170478044765 no 3220 0.0510107639481286 4573 2173356 SGTC_3212 9128307 49.47 µM -1.63564024271824 0.0414683770822807 no 3221 0.0509574513935005 4461 27243542 SGTC_827 3253-0474 693 µM -1.63854223043046 0.041191744736407 no 3222 0.0506543160460343 4571 5402065 SGTC_674 0498-0004 451 µM -1.64182000699701 0.0408810915898022 no 3223 0.0503136557546448 4557 4231473 SGTC_3121 9125696 49.47 µM -1.6437420387692 0.040699815693407 no 3224 0.0501147492071415 4656 1235365 SGTC_1933 st074711 15.9 µM -1.64616391353927 0.0404723266677293 no 3225 0.0498650083136354 4559 17250958 SGTC_1487 3970-0795 2.82 µM -1.65816543611656 0.0393601999746065 no 3226 0.0486420395519578 4623 3765103 SGTC_430 0958-0115 16.4 µM -1.65866153135808 0.0393147696310672 no 3227 0.0485920076034914 4502 6833180 SGTC_1372 2752-0194 270 µM -1.66013332417892 0.0391802399714222 no 3228 0.0484438171556761 4506 823334 SGTC_165 k038-0023 64.381 µM -1.66038384030231 0.0391573788297608 no 3229 0.0484186294633684 4542 46368543 SGTC_2643 anethole 100 µM -1.66170035645217 0.0390374170064758 no 3230 0.0482864348191776 4583 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2173 5763948 167 µM -1.67478085134945 0.0378616961907181 no 3231 0.0469886186223889 4553 2867177 SGTC_1419 3993-2473 62.6 µM -1.67821372246769 0.0375579715511956 no 3232 0.0466526919060333 4642 704026 SGTC_1937 st074714 47.2 µM -1.68220942145697 0.0372069590211195 no 3233 0.046264118917345 4513 17250970 SGTC_664 1222-0054 14.9 µM -1.69012818270166 0.0365192349919251 no 3234 0.0455017171030248 4558 6813991 SGTC_983 1491-0821 12.2 µM -1.69407232046289 0.0361805971036265 no 3235 0.045125770662359 4586 46495113 SGTC_1905 st060207 84.5 µM -1.69812110781786 0.0358356528280917 no 3236 0.044742453244368 4572 1948547 SGTC_1029 k015-0030 64.7 µM -1.69818392008661 0.0358303227154771 no 3237 0.0447365272357493 4609 2208316 SGTC_1299 1079-1439 3.74 µM -1.70456967689367 0.0352918216358199 no 3238 0.0441373553741649 4579 323161 SGTC_82 0054-0107 293.755 µM -1.70570263415682 0.0351969779800484 no 3239 0.0440317294901931 4567 3104697 SGTC_1782 st039423 80.636 µM -1.71288210404549 0.0346008105494839 no 3240 0.0433671156237197 4604 2068169 SGTC_596 1155-0152 116 µM -1.71481278574364 0.0344419137985631 no 3241 0.0431897783064008 4616 280313 SGTC_3312 9133330 71.43 µM -1.71818900710987 0.0341654890811911 no 3242 0.042881072990498 4607 17617324 SGTC_2266 7929956 200 µM -1.72960506369302 0.0332442905365896 no 3243 0.0418504303644236 4565 2967153 SGTC_3169 9102970 49.47 µM -1.73753560043032 0.0326164693815686 no 3244 0.0411463379131808 4651 17027839 SGTC_1625 st003711 30.1 µM -1.74300101112443 0.032189516961617 no 3245 0.0406667190990634 4610 24207034 YER133W GLC7 SGTC_2760 etidronate 98.04 µM -1.74849844029653 0.0317647278251995 no 3246 0.0401888777213932 4563 3305 A chelator and antioxidant. SGTC_951 1171-0579 82.7 µM -1.75893956534315 0.0309706875977149 no 3247 0.0392938870073503 4538 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_858 0438-0351 2.77 µM -1.76023055450716 0.0308736598048106 no 3248 0.0391843616804805 4605 2799119 SGTC_138 0850-0259 40.9225 µM -1.7684414952048 0.0302624171498754 no 3249 0.038493562352655 4561 6813004 SGTC_1369 1866-0067 208 µM -1.76915219835676 0.0302099856054843 no 3250 0.0384342394644979 4616 3531355 SGTC_1711 st032263 62.8 µM -1.77961655834257 0.0294466638124895 no 3251 0.0375693672357651 4616 3958979 SGTC_3115 9123671 49.47 µM -1.78008212431418 0.0294130786287156 no 3252 0.0375312607896886 4707 3286988 SGTC_661 1304-0007 33.6 µM -1.78420101113836 0.029117331885149 no 3253 0.0371955040399002 4637 3117130 SGTC_1462 k081-0014 26.5 µM -1.79069219110556 0.0286562658768753 no 3254 0.0366713517609818 4050 3270634 SGTC_261 5-fluorouridine 15.376 µM -1.79810491512855 0.0281371852901874 no 3255 0.03608019174779 4628 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3130 9127414 49.47 µM -1.80563064700245 0.027618223510458 no 3256 0.0354880261259432 4657 1494646 SGTC_1633 st005664 67.9 µM -1.80939081343071 0.027361932595971 no 3257 0.0351951546744328 4614 2063822 SGTC_1899 st063254 59.6 µM -1.80988473372996 0.0273284151073234 no 3258 0.0351568320200044 4594 3093813 SGTC_2826 7992541 19.48 µM -1.81167171553531 0.0272074362537159 no 3259 0.0350184682524138 4620 2985066 SGTC_754 3474-0146 171 µM -1.82290680087583 0.0264570137592586 no 3260 0.0341587538590504 4620 24762078 SGTC_2508 celastrol 40.54 µM -1.82591239725649 0.0262592197915855 no 3261 0.0339317292456435 4587 122724 Celastrol is a natural product and antioxidant. SGTC_1515 3460-0031 42.1 µM -1.82992040212021 0.0259973835715859 no 3262 0.0336309210890503 4619 2876596 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.83683284391211 0.0255509374298493 no 3263 0.0331172878479572 4596 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1066 ketoconazole 628 nM -1.84314356227446 0.0251489773018835 no 3264 0.032654026238524 4678 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1336 1486-0901 104 µM -1.85482908580387 0.0244186590700586 no 3265 0.0318103185746786 4651 5006114 SGTC_3123 9126162 49.47 µM -1.85584582876742 0.0243559656215854 no 3266 0.0317377680902832 4633 25239884 SGTC_2028 5153890 36.43 µM -1.85592021316713 0.0243513843107272 no 3267 0.0317324657047909 4633 2830968 YPR165W RHO1 SGTC_172 1112-0046 2.638 µM -1.87755737426837 0.0230491278251711 no 3268 0.0302208707875695 4643 2802135 YIL048W NEO1 SGTC_603 3794-0023 45.9 µM -1.87913335524637 0.0229566115822643 no 3269 0.0301131433539454 4694 3802260 SGTC_231 b-estradiol 524 µM -1.88497039620893 0.022616674669013 no 3270 0.0297169173731352 4667 450 A steroid. SGTC_1355 1499-0035 1.68 µM -1.88615388537924 0.0225482706860895 no 3271 0.029637110342731 4663 1548538 SGTC_2381 9035592 200 µM -1.91408407843792 0.0209838755665965 no 3272 0.0278047067733116 4672 4749657 SGTC_187 1488-2104 32.728 µM -1.92311746307119 0.0204979868884682 no 3273 0.0272326498396301 4660 2852859 SGTC_2725 haloperidol 53.21 µM -1.92570365582699 0.020360648321903 no 3274 0.02707069357712 4642 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3184 9108758 49.47 µM -1.92771641573478 0.0202543020707428 no 3275 0.0269452045537819 4713 902885 SGTC_2023 5144124 124 µM -1.92987359525417 0.0201408484532628 no 3276 0.0268112509128401 4638 2830192 SGTC_2470 5664817 21.68 µM -1.93122068856624 0.020070273818026 no 3277 0.0267278832926029 4718 2859561 SGTC_2083 5306046 65.942 µM -1.93211667550311 0.0200234490306852 no 3278 0.0266725532823027 4667 539837 SGTC_3290 9121031 71.43 µM -1.94114651140389 0.0195566960253622 no 3279 0.0261202544179692 4675 17014854 SGTC_2330 7979373 200 µM -1.94177838967044 0.019524382981094 no 3280 0.0260819670490403 4602 1863007 SGTC_1602 st001878 87.6 µM -1.94717098064541 0.0192504565472701 no 3281 0.0257571197624207 4643 595405 YLR310C CDC25 SGTC_644 1498-1197 63.3 µM -1.95272010971165 0.018971995396979 no 3282 0.0254263847404034 4698 6741615 SGTC_415 dibenzyl ketone 100 µM -1.96949998951027 0.0181507174455204 no 3283 0.024447851890873 4665 7593 SGTC_43 0570-0105 72.5 µM -1.97882435705195 0.0177075826007063 no 3284 0.0239178925767647 4644 1114046 YDL195W SEC31 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.98648541065764 0.0173504356094304 no 3285 0.0234897256052914 4669 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1463 k081-0032 34.1 µM -1.99824940787808 0.0168139988799599 no 3286 0.0228448137129263 4201 977755 SGTC_2013 4024628 200 µM -2.00360671645628 0.0165744464056525 no 3287 0.0225561029112473 4676 5230760 SGTC_2855 9016525 58.44 µM -2.01571345913545 0.0160438304139574 no 3288 0.0219149737006971 4643 43811474 SGTC_2553 4-methylesculetin 85.09 µM -2.02143009140577 0.0157983843179409 no 3289 0.0216176311645832 4673 5319502 SGTC_2596 sinensetin 100 µM -2.02977702894159 0.0154457923087738 no 3290 0.0211896044667411 4661 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_854 0422-0053 192 µM -2.03867080733492 0.0150775556712597 no 3291 0.020741446583198 4709 3596728 SGTC_980 1473-0395 201 µM -2.04882282869011 0.014666467685337 no 3292 0.0202397213156116 4658 768876 SGTC_1199 1638-0010 4.46 µM -2.04890668096846 0.0146631127947046 no 3293 0.0202356204636999 4690 3111136 SGTC_853 0419-0306 21 µM -2.05947757855347 0.0142454303150101 no 3294 0.0197242553731439 4738 762713 SGTC_168 3970-0862 530.542 µM -2.07424272114452 0.0136792010527349 no 3295 0.019028387225483 4635 3135186 SGTC_3333 9141820 12.094 µM -2.08366948144679 0.0133279404206266 no 3296 0.0185951210357775 4680 1939433 SGTC_3331 9141060 1.957 µM -2.11781309198896 0.0121201019124566 no 3297 0.0170954500636671 4685 4906567 YPR165W RHO1 SGTC_1297 1068-0111 14.1 µM -2.13734940075271 0.0114726121022605 no 3298 0.0162847918161135 4714 767057 SGTC_338 4055-0136 114 µM -2.14917437531574 0.0110954736336367 no 3299 0.0158102898766237 4708 2900563 SGTC_2735 sertaconazole 140 nM -2.16167200860866 0.0107086466055334 no 3300 0.0153217333428763 4773 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_473 2-arachidonoylglycerol 10 µM -2.16728820475773 0.0105386734306356 no 3301 0.0151064426627648 4613 5282280 An endocannabinoid. SGTC_1342 1486-1464 234 µM -2.17607333722229 0.0102775068887274 no 3302 0.0147748886235315 4739 3253938 SGTC_2383 9036125 200 µM -2.187855695077 0.0099361091444284 no 3303 0.0143400577143577 4702 79580 SGTC_1743 st037606 46.3785 µM -2.18873669588574 0.00991098434572302 no 3304 0.0143079915945947 4687 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2351 9026858 72.31 µM -2.19309342845469 0.00978755073841228 no 3305 0.0141503242007395 4656 1409300 SGTC_2571 chrysanthemic acid 100 µM -2.21027780388352 0.00931368814347394 no 3306 0.0135429440495748 4699 2743 An insecticide. SGTC_136 0097-0015 404.482 µM -2.22042660195347 0.00904336466138318 no 3307 0.0131949114659625 4714 4861337 SGTC_2400 5203494 178.7 µM -2.22094381007734 0.00902977422206274 no 3308 0.0131773837136244 4661 6777674 SGTC_384 k007-0144 5.16 µM -2.22687881902254 0.00887509848259386 no 3309 0.0129776868959687 4712 6824886 SGTC_2069 5228469 200 µM -2.23754929119758 0.00860284187873575 no 3310 0.0126252307649895 4719 2835210 SGTC_2299 7976368 114.88 µM -2.25559348406394 0.00815909146536808 no 3311 0.0120480508340016 4724 2979718 SGTC_3178 9107506 49.47 µM -2.25736727584177 0.00811657486058124 no 3312 0.0119925673754486 4711 8897194 SGTC_2695 st077686 51.995 µM -2.25992827193713 0.00805553299928357 no 3313 0.0119128514593518 4704 2876092 SGTC_1520 flindersine 88 µM -2.26175253932002 0.00801229766721283 no 3314 0.0118563483246293 4716 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_901 1112-0062 60.1 µM -2.26890554406195 0.00784473267343903 no 3315 0.011637035258963 4752 1908457 SGTC_3120 9124077 49.47 µM -2.28310562699158 0.00752119572813592 no 3316 0.0112120735967773 4782 18774327 YGL155W CDC43 SGTC_3088 9117578 49.47 µM -2.28973286969646 0.00737426434428349 no 3317 0.0110184033741998 4764 678341 SGTC_579 4491-1009 110 µM -2.30259093630852 0.00709639027745805 no 3318 0.0106509348008043 4747 1271041 SGTC_2822 7994718 71.43 µM -2.31984086948909 0.00673813337031411 no 3319 0.0101747436412135 4743 1018011 SGTC_905 2-aminofluorene 215 µM -2.32621868274668 0.00660977879539348 no 3320 0.0100034437422057 4751 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3113 9123498 49.47 µM -2.34580121436182 0.00622908329316346 no 3321 0.00949311523926436 4785 8897275 SGTC_2624 nerol 100 µM -2.3554735849036 0.0060483124822867 no 3322 0.00924955611635632 4681 637566 A natural product oil. SGTC_1550 gossypolone 36.6 µM -2.3862069715649 0.00550439663337069 no 3323 0.00851158376972954 4759 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2184 6075246 200 µM -2.44188582143765 0.00462871883042523 no 3324 0.00730538339273532 4756 2267320 SGTC_257 daunorubicin 18.5 µM -2.48733408183181 0.00400846893936678 no 3325 0.00643522364532046 4778 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_400 oxethazaine 37.5 µM -2.50582446532299 0.00377819887103875 no 3326 0.00610831261995832 4777 4621 A local anesthetic. SGTC_952 1185-0122 232 µM -2.54781487651779 0.00329874304749347 no 3327 0.00541999888615092 4734 678600 SGTC_3122 9126309 49.47 µM -2.56376647884037 0.00313144828757615 no 3328 0.00517715915436816 4789 17591206 SGTC_414 piperonyl butoxide 100 µM -2.57574164436113 0.00301091861027103 no 3329 0.00500126767243917 4770 5794 A potent inhibitor of cytochrome P450. SGTC_2017 5132927 60.65 µM -2.58789782224899 0.00289285762075377 no 3330 0.00482818098167037 4744 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_140 0062-0056 502.533 µM -2.59407084448816 0.00283451755322932 no 3331 0.00474234704547049 4702 3758964 SGTC_2774 tamoxifen 10.92 µM -2.64143704983622 0.00242102388034059 no 3332 0.00412775735451031 4770 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2956 9076196 2.52 µM -2.65846496020481 0.0022862610688018 no 3333 0.00392487564054594 4764 16423868 SGTC_332 4112-0506 40.9 µM -2.66755413728498 0.00221714289916472 no 3334 0.0038202789240842 4778 2790355 SGTC_1934 st074720 32.6 µM -2.67978499783851 0.00212712271219943 no 3335 0.00368347305561317 4736 17250992 SGTC_2900 5328528 85.29 µM -2.71728368453176 0.00187140600703156 no 3336 0.00329100824778559 4750 795359 SGTC_949 1165-0505 146 µM -2.71923078367827 0.0018589248356295 no 3337 0.00327169681664938 4757 6244267 SGTC_2806 7952793 58.44 µM -2.8231088345744 0.00129314487198636 no 3338 0.00237802117366011 4769 2972490 SGTC_2265 7929201 200 µM -2.84336686186655 0.00120315333006934 no 3339 0.00223198276288845 4766 1265108 SGTC_2512 diallyl trisulfide 49.23 µM -2.8565385905411 0.00114775582700783 no 3340 0.00214143968594717 4787 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1197 1601-0112 267 µM -2.87794407627135 0.0010626922362207 no 3341 0.00200138045671677 4780 7350313 SGTC_1195 1502-0147 41.1 µM -2.92349480510643 0.000900589692341228 yes 3342 0.00173063000431688 4798 817940 SGTC_2168 5727979 200 µM -2.97519188330168 0.000744329348015187 yes 3343 0.00146402665692728 4781 695210 SGTC_1159 4092-0538 61.2 µM -2.9774731010589 0.000738047232481118 yes 3344 0.00145317573222702 4790 717301 SGTC_2756 carbadox 75.1 µM -3.3124117552549 0.000199953597403769 yes 3345 0.000462476505018838 4771 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1210 3013-0140 750 nM -3.34634065745102 0.000173983618944484 yes 3346 0.000409428638354031 4801 905973 SGTC_1185 1319-0113 81.3 µM -3.36053403863537 0.000164085456611487 yes 3347 0.000388959721973215 4800 4672763 SGTC_2270 7924575 90.91 µM -3.41223064234693 0.000132313658907551 yes 3348 0.000322167853319173 4792 1262135 SGTC_2404 5161160 200 µM -3.41242980176514 0.000132203253520747 yes 3349 0.000321932538660476 4795 2831543 SGTC_1265 0819-1001 68.8 µM -3.52767945464106 8.09606032872005e-05 yes 3350 0.000209609743199054 4784 3106768 SGTC_141 0443-0274 32.331 µM -3.92103701511453 1.35974389453438e-05 yes 3351 4.40843584111741e-05 4797 1627241 SGTC_2775 cyproheptadine 69.59 µM -3.92363448662699 1.34305390592257e-05 yes 3352 4.36115190688686e-05 4803 2913 A selective serotonin reuptake inhibitor. SGTC_1264 0783-0040 158 µM -3.94111673370745 1.23568758369342e-05 yes 3353 4.05515712386988e-05 4800 2855798 SGTC_2767 sibutramine 71.45 µM -3.97888309539074 1.0309477190281e-05 yes 3354 3.46198870423851e-05 4806 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_335 4077-0256 27.6 µM -4.33632177159926 1.71593083112376e-06 yes 3355 7.24434016914535e-06 4783 3121989 SGTC_139 0099-0334 718.624 µM -5.82663294781407 2.07190617678937e-10 yes 3356 2.82784074421828e-09 4807 97690