SGTCid condition conc unit MIP1|YOR330C.score MIP1|YOR330C.strain.pval MIP1|YOR330C.strain.significant MIP1|YOR330C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_236 1509-0011 5.31 µM 39.6289823575347 0 yes 1 0 1 3107280 SGTC_386 1509-0011 3.07 µM 17.4906966615644 3.94419286721046e-85 yes 2 8.43412874635929e-69 14 3107280 SGTC_1635 st007035 42.4 µM 11.4035142784337 2.02146892724805e-37 yes 3 2.00787372444098e-30 65 3716403 SGTC_275 trichlorophene 5.69 µM 9.97134185268747 4.34058236788608e-29 yes 4 1.01730591461966e-23 46 62616 SGTC_1188 1403-0014 4.57 µM 8.94030862587862 9.02232835101357e-24 yes 5 1.94042492561938e-19 3 9614867 SGTC_365 0121-0052 13.6 µM 8.82221645241615 3.37361829115507e-23 yes 6 5.61080359862331e-19 5 3101739 SGTC_134 0269-0018 6.916 µM 8.34114105128282 6.08690695901642e-21 yes 7 3.67885339364409e-17 58 4378915 SGTC_70 0141-0289 43.283 µM 7.36732431145863 9.40879802631442e-17 yes 8 8.70433141399549e-14 48 352408 SGTC_908 3448-7491 47.7 µM 5.7544947224632 6.33467773779601e-11 yes 9 4.34506599984959e-09 55 1203031 SGTC_2250 alverine citrate 130 µM 5.70979668398809 8.78240465202111e-11 yes 10 5.65556084613865e-09 60 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_119 0121-0043 24.815 µM 5.66511239498235 1.21451732579718e-10 yes 11 7.34640977656898e-09 30 1092378 SGTC_2582 agaric acid 100 µM 4.70957673404934 6.97104919394177e-08 yes 12 1.24115873808804e-06 242 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1722 st034304 3.6505 µM 4.50269294562575 2.38506729044422e-07 yes 13 3.35488958539656e-06 15 4036148 YLR033W RSC58 SGTC_1418 3966-3099 2.4 µM 4.44908544395931 3.2529126642648e-07 yes 14 4.31183534148232e-06 13 740335 SGTC_283 0987-0079 11.7 µM 4.40877565976105 4.09849781165263e-07 yes 15 5.19783204901972e-06 15 411556 SGTC_168 3970-0862 530.542 µM 4.21735210526935 1.19567192664144e-06 yes 16 1.2359391905713e-05 104 3135186 SGTC_2375 9072683 200 µM 3.82426417422281 9.39137144981291e-06 yes 17 6.55816106525301e-05 22 16798029 SGTC_1938 st074717 56.4 µM 3.78554348141179 1.13911845826473e-05 yes 18 7.66865062680221e-05 14 17250979 SGTC_116 0155-0182 31.788 µM 3.76519779569153 1.25982936476881e-05 yes 19 8.32086458505744e-05 92 771486 SGTC_435 c-PAF 6.7 µM 3.60762832764708 2.70300791386392e-05 yes 20 0.00015450435674574 60 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2576 guaiol 23.12 µM 3.55128227940141 3.52611520000743e-05 yes 21 0.00019167950976832 39 227829 SGTC_279 1273-0055 2.93 µM 3.54498565462061 3.63158612945824e-05 yes 22 0.000196317227178284 51 2847562 SGTC_2523 spermine 47.74 µM 3.44966717476711 5.64119666827775e-05 yes 23 0.000280639041497482 39 1103 A DNA binding polyamine. SGTC_2932 9016711 44.54 µM 3.35354712072879 8.70025107977742e-05 yes 24 0.000398914139626782 70 7117328 SGTC_1882 5615643 20 µM 3.3198853187355 0.00010099674167169 yes 25 0.000450272168079443 44 2253075 SGTC_1883 5-benzylidenerhodanine 20 µM 3.31479562787355 0.000103288269284296 yes 26 0.00045855074207667 107 1273210 SGTC_173 1273-0061 2.693 µM 3.28809074033085 0.000116133439550266 yes 27 0.000504346612973284 216 2847414 YPL266W DIM1 SGTC_2107 5363541 170.161 µM 3.16532012863941 0.000196925044888887 yes 28 0.00077456204468706 25 244052 SGTC_2278 7948257 134.34 µM 3.09904547841448 0.000259963044306226 yes 29 0.000970726080078968 47 1247028 SGTC_748 act1.228 77.9 µM 3.09007842420354 0.000269810391859044 yes 30 0.00100051825764692 126 4421505 YNR035C ARC35 SGTC_852 0418-0143 439 µM 2.96860852448117 0.000442349255988209 yes 31 0.00149575722639502 134 5369229 SGTC_623 k072-0108 16.9 µM 2.95306514752316 0.000470651059848181 yes 32 0.00157317777024849 67 5382803 SGTC_1796 st049173 110.4 µM 2.8758466246879 0.000637809493751606 yes 33 0.00201472727101345 37 94134 SGTC_108 0509-0257 621.132 µM 2.85831076246671 0.000682724424503468 yes 34 0.00212951529855929 114 536624 SGTC_2126 5251174 33.877 µM 2.84245582998471 0.000725827159422932 yes 35 0.00223837169505601 117 790722 SGTC_2935 9038016 29.96 µM 2.83986017535139 0.000733118001063099 yes 36 0.00225666560263136 79 6463195 SGTC_1464 k208-0027 110 µM 2.81774399383662 0.000798032344015687 yes 37 0.00241811767962289 74 X1464 SGTC_214 4373-3496 70 µM 2.81709756804781 0.000800006946548501 yes 38 0.00242299009634881 148 3779166 SGTC_1742 st038235 28.8875 µM 2.77782514679118 0.000928758545166554 yes 39 0.00273620289270837 195 564103 YBR002C RER2 SGTC_1946 st076057 65.1 µM 2.77572343386589 0.000936158215572504 yes 40 0.00275395195954715 36 953009 SGTC_2646 retinol 96.75 µM 2.76446786349952 0.000976716455920182 yes 41 0.00285078615303534 62 445354 A vitamin A analog and teratogen. SGTC_10 0279-0212 42.575 µM 2.71937382019284 0.00115590885465317 no 42 0.00327028219952368 231 39851 YBR002C RER2 SGTC_1727 st034309 9.9045 µM 2.7188745168794 0.00115805150536111 no 43 0.00327522265320302 135 870305 SGTC_251 melphalan 456.522 µM 2.60637424523603 0.00174483636912039 no 44 0.0045753209353002 126 460612 A DNA alkylator. SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.60487126735031 0.00175424467282862 no 45 0.00459543925270727 137 1273210 SGTC_725 1497-0963 19 µM 2.56984681974699 0.00198698376735959 no 46 0.00508717460952406 89 3549977 SGTC_312 4092-0653 6.84 µM 2.55338345979952 0.00210578637634366 no 47 0.00533409865890237 195 1148278 SGTC_127 0180-0333 59.125 µM 2.5421177336077 0.00219075653502357 no 48 0.00550915261864393 177 771601 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.53939201667031 0.00221177635851613 no 49 0.00555226594978972 110 5393153 SGTC_503 tyrphostin 8 294 µM 2.53197062189625 0.00226993723094945 no 50 0.00567117469407018 134 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_831 k061-1017 217 µM 2.50421889346002 0.00249990529907354 no 51 0.0061361041277612 215 1240153 SGTC_767 0929-0023 86 µM 2.49757462836383 0.0025579999777432 no 52 0.0062523070738445 230 1204563 SGTC_335 4077-0256 27.6 µM 2.48584546235297 0.00266354038636378 no 53 0.00646220381239289 110 3121989 SGTC_2812 7970281 58.44 µM 2.4577831775452 0.00293218269551579 no 54 0.00698987739598929 144 2233435 SGTC_745 0469-0705 296 µM 2.43252746136675 0.00319458330211386 no 55 0.00749692723711452 146 3486736 SGTC_1369 1866-0067 208 µM 2.40051962673529 0.00355740907649148 no 56 0.00818590638158731 161 3531355 SGTC_1428 4049-0204 61.7 µM 2.39342349542282 0.00364269393957993 no 57 0.00834598100774859 117 X1428 SGTC_2230 bromochlorosalicylanilide 954.5 nM 2.3803052135271 0.0038052000519467 no 58 0.0086491518625896 64 77254 SGTC_2121 5257820 149.641 µM 2.36991331145148 0.00393851381449453 no 59 0.00889612818738006 121 791256 SGTC_150 3970-0969 77.2 µM 2.35185868130022 0.00418010717667441 no 60 0.00933993514658966 220 6615640 SGTC_539 4859-0462 2.54 µM 2.34348963967408 0.00429652684337619 no 61 0.00955214641066149 144 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_327 1273-0057 3.96 µM 2.34218126463136 0.00431498700885586 no 62 0.00958570067736698 132 3108138 SGTC_2766 oltipraz 83.91 µM 2.34021174985389 0.0043429090466124 no 63 0.0096364046434408 146 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1231 0242-0792 125 µM 2.33936800914497 0.00435492018296976 no 64 0.00965819785423659 135 3707635 SGTC_1255 0566-0045 221 µM 2.33063826607204 0.004480946674648 no 65 0.00988622096705648 170 2788469 SGTC_321 4534-3890 65.3 µM 2.30429807381358 0.00488117594565418 no 66 0.0106029585089639 104 699746 SGTC_793 0488-0545 106 µM 2.29818815567296 0.00497844786602128 no 67 0.0107755412649877 158 292548 SGTC_1434 4073-0095 163 µM 2.29063536205017 0.00510107500746179 no 68 0.0109922559630294 114 24133745 SGTC_2101 5377231 179.231 µM 2.28797082569498 0.00514497380640309 no 69 0.0110696100752545 112 2844213 SGTC_141 0443-0274 32.331 µM 2.28588047780921 0.00517964776358096 no 70 0.0111306259182838 256 1627241 SGTC_1448 4255-0083 152 µM 2.27565617900378 0.0053522584685601 no 71 0.0114332980320835 149 5399660 SGTC_2384 9036245 200 µM 2.27292988211557 0.00539914028084649 no 72 0.0115152028553041 144 6462766 SGTC_87 0100-0052 35.5 µM 2.26632527678634 0.00551423069197724 no 73 0.0117157374549887 368 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_310 1273-0058 1.06 µM 2.25329425233281 0.00574771715983251 no 74 0.0121203009624478 482 2734232 SGTC_2358 9037157 4 µM 2.24410325232196 0.0059176349068143 no 75 0.0124128793815772 176 2388925 SGTC_2380 9035439 200 µM 2.23560231174988 0.00607874545436241 no 76 0.012688916518672 176 6462575 SGTC_1371 2421-0008 32.7 µM 2.22530790911438 0.00627904078136642 no 77 0.0130302874330592 209 2827552 SGTC_1226 3909-7979 35.4 µM 2.2216749769768 0.00635110822159086 no 78 0.0131526394028754 192 6615510 SGTC_368 fentichlor 4.58 µM 2.21715003422528 0.00644189391128312 no 79 0.0133064203372208 153 7329 A pesticide. SGTC_1939 st074455 53.6 µM 2.21502885444281 0.00648484586160193 no 80 0.0133790420318597 186 1644229 SGTC_1972 st070201 17.4 µM 2.19434304013269 0.00691717858681138 no 81 0.0141053787300052 155 2829099 SGTC_1233 0325-0408 14.2 µM 2.19152001266705 0.00697811143109928 no 82 0.0142070915700592 174 12874 SGTC_1138 3761-0006 1.03 µM 2.18545618829104 0.00711059862650161 no 83 0.0144277074644087 113 12061087 SGTC_769 0302-0231 76 µM 2.17117643107169 0.00743139621521529 no 84 0.0149589191238801 248 571869 YER009W NTF2 SGTC_59 0330-0160 1.33 µM 2.16498558724179 0.00757439252312771 no 85 0.0151943945176855 356 4293482 SGTC_1622 st003707 19.4 µM 2.15896857480631 0.00771569009009087 no 86 0.0154263025085258 236 10140899 SGTC_149 3970-0822 46.1 µM 2.15631221816178 0.00777880402648317 no 87 0.0155296469273137 330 3114250 YBL034C STU1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.15296920390509 0.00785887796810999 no 88 0.0156605494595 199 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1508 1080-0625 72.9 µM 2.14522082082178 0.00804726562481597 no 89 0.0159675978315949 147 767111 SGTC_2307 7538926 6.34 µM 2.12966529416161 0.00843748861151576 no 90 0.0165996281094106 228 96582 SGTC_1411 3909-8223 150 µM 2.1285767372717 0.00846540753992416 no 91 0.016644647425102 160 X1411 SGTC_2595 hexamethylquercetagetin 100 µM 2.12062565271056 0.00867180450606618 no 92 0.0169766587983946 179 386331 SGTC_1828 st055811 49 µM 2.11892735003803 0.00871645729408916 no 93 0.0170483035772935 127 5877589 SGTC_2008 4012253 172 µM 2.1107012679618 0.00893560736070451 no 94 0.0173989984731801 227 603940 SGTC_1488 4013-0813 75.9 µM 2.1080271748606 0.00900787985705847 no 95 0.0175143194518764 133 2910057 SGTC_1935 st074532 41.6 µM 2.10706589461827 0.00903398512960806 no 96 0.0175559340650189 230 2829742 SGTC_2097 5376186 200 µM 2.09864913023524 0.00926540148051412 no 97 0.0179239210110097 212 742755 SGTC_2424 5537928 59.2 µM 2.09445804809011 0.00938255666250495 no 98 0.0181095982187638 241 5382802 SGTC_1703 st026983 48.3 µM 2.05098517121072 0.0106762598161448 no 99 0.0201341954283775 195 1104023 SGTC_2933 9026794 32.47 µM 2.04833032052099 0.0107600711567765 no 100 0.0202638219835554 228 17586027 SGTC_46 0329-0187a 2.197 µM 2.04230689233445 0.0109523525583313 no 101 0.0205605494276047 305 46494817 SGTC_2759 disulfiram 3.38 µM 2.03416804407679 0.0112169078731469 no 102 0.0209673276553401 222 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2430 5571206 200 µM 2.03275834817154 0.0112632904712915 no 103 0.0210384715656532 249 1731771 SGTC_19 0279-0214 38.434 µM 2.02475645050811 0.0115297448589762 no 104 0.02144618945494 313 3566274 YBR002C RER2 SGTC_2158 5657123 3.6195 µM 2.019379510958 0.0117118512244668 no 105 0.0217238947225193 170 2858827 SGTC_1705 st027868 56.3335 µM 2.0173434483535 0.0117814574904895 no 106 0.0218298422123506 185 292948 SGTC_2848 9016370 25.97 µM 2.00463757255182 0.012223992067281 no 107 0.0225009034213623 237 7894410 SGTC_1284 0929-0043 16 µM 2.00330749069471 0.0122711400811092 no 108 0.0225721469865113 230 1239883 SGTC_81 0411-0046 9.971 µM 2.00067914322702 0.0123647717883784 no 109 0.0227134892430482 194 12925265 SGTC_159 3970-0959 50 µM 2.00037814877056 0.0123755337437274 no 110 0.0227297230496301 426 6615653 SGTC_2802 7925815 54.55 µM 1.98955813286705 0.0127678252059464 no 111 0.0233198160094303 260 1262923 SGTC_1219 1469-0211 33.1 µM 1.98945583551495 0.0127715848641044 no 112 0.0233254559652774 177 6822282 SGTC_2052 5265182 7.135 µM 1.98908088353725 0.012785373384094 no 113 0.0233461379938712 230 1239884 SGTC_2692 st077426 47.7 µM 1.96854780036832 0.013560383329736 no 114 0.0245025209399914 233 25238571 SGTC_2584 androsterone 48.74 µM 1.96436571003187 0.0137231109543299 no 115 0.0247438482034637 407 2754130 A steroid. SGTC_2183 6420625 130.508 µM 1.96032556451052 0.0138819124855928 no 116 0.0249788749202306 313 2897619 SGTC_886 0866-0150 153 µM 1.96004134053109 0.01389314358151 no 117 0.0249954792664228 259 271463 SGTC_2806 7952793 58.44 µM 1.94203699756302 0.0146207346889205 no 118 0.0260663107752858 237 2972490 SGTC_778 3456-2434 196 µM 1.9381507504026 0.014782018339538 no 119 0.0263024166478259 321 5539063 SGTC_2010 4012422 159 µM 1.93739614047792 0.0148135122868257 no 120 0.0263484690317224 237 952393 SGTC_3007 9078383 71.4286 µM 1.91941607115476 0.0155811687906537 no 121 0.027465849320744 235 6496995 SGTC_1232 0279-0259 161 µM 1.91936982598513 0.0155831864247859 no 122 0.02746877341226 247 1560000 SGTC_2711 st079103 59.1 µM 1.91820542936449 0.0156340619198499 no 123 0.0275424840367834 193 54693780 SGTC_614 0462-0418 107 µM 1.9179000790091 0.0156474270287843 no 124 0.0275618411143206 249 5188303 SGTC_2693 st077581 40.7 µM 1.91179403293366 0.0159167524058684 no 125 0.0279513087246093 334 25238761 SGTC_820 1582-0060 59.9 µM 1.90978750653457 0.0160061195250019 no 126 0.0280802892691006 267 3848840 SGTC_2167 5876490 200 µM 1.90382060715806 0.0162744200488516 no 127 0.028466775880026 248 686534 SGTC_865 0488-0499 301 µM 1.89699084065619 0.0165862384405464 no 128 0.0289145734822634 240 9634651 SGTC_1040 k898-0338 155 µM 1.89117618242805 0.0168557272444859 no 129 0.029300414813785 283 20969351 SGTC_2362 9071156 126 µM 1.88164530518348 0.017305548269812 no 130 0.0299420952691163 253 653133 SGTC_3342 9147791 14.508 µM 1.87046697918047 0.0178461507281798 no 131 0.0307094991727088 241 1838168 SGTC_38 0929-0051 58.268 µM 1.86948540450842 0.0178943019452424 no 132 0.0307776561938974 286 1379719 SGTC_596 1155-0152 116 µM 1.8685492661927 0.017940327463527 no 133 0.0308427749029054 332 280313 SGTC_676 falcarinol 140 µM 1.86492429309395 0.0181195038399261 no 134 0.03109600837333 287 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_876 0720-0963 56.8 µM 1.86441538670447 0.0181447799270866 no 135 0.0311316968829144 248 765861 SGTC_2150 5556613 200 µM 1.85953349103787 0.0183887818844682 no 136 0.0314757783288354 273 743190 SGTC_994 3910-0338 138 µM 1.84990945069749 0.0188779936759568 no 137 0.0321633007662993 309 3479481 SGTC_1606 st000094 49.2 µM 1.81153029625001 0.0209404618806269 no 138 0.0350294018620592 271 1242210 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.80968117568025 0.0210444700757365 no 139 0.0351726216835496 227 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_398 bronopol 33.3 µM 1.80793789893476 0.0211429248144886 no 140 0.0353080832004185 294 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2163 5671233 125 µM 1.79457022207459 0.0219109158851101 no 141 0.0363611005417132 313 701023 SGTC_1041 0206-0046 107 µM 1.78929386467704 0.0222204677990117 no 142 0.0367837508147228 281 50494 SGTC_1043 0916-0009 19.3 µM 1.78322515744143 0.0225810600357384 no 143 0.0372748294132718 357 3101130 SGTC_2797 7859098 81.82 µM 1.77921779108883 0.0228218653554646 no 144 0.0376020313373188 310 972681 SGTC_930 2810-3379 265 µM 1.77781029453431 0.0229069546066797 no 145 0.0377175085776542 323 1015764 SGTC_131 0141-0277 33.849 µM 1.77676774176607 0.0229701535900381 no 146 0.0378032307066529 322 1547771 SGTC_284 0988-0104 32.6 µM 1.77540457272167 0.0230530096609681 no 147 0.0379155547639639 281 4666532 SGTC_530 4358-1714 28 µM 1.76497861481666 0.0236950809886099 no 148 0.0387836799419992 357 1564641 SGTC_3013 9080133 71.4286 µM 1.74694508276554 0.0248411479699821 no 149 0.0403234323142742 347 17050193 SGTC_2435 5706476 10.6 µM 1.73947569207412 0.0253292763123626 no 150 0.0409755621562464 329 5725375 SGTC_933 2914-0560 114 µM 1.73508608228597 0.0256198701525676 no 151 0.0413627795445469 342 463887 SGTC_1621 st003705 32.4 µM 1.73396923499379 0.0256942496801137 no 152 0.0414617710011184 354 24207032 SGTC_2770 toltrazuril 17.5 µM 1.7337752952473 0.0257071840342281 no 153 0.0414789803449063 323 68591 Kills coccidiodes. SGTC_1507 4075-3230 155 µM 1.72518239985145 0.0262857612991107 no 154 0.0422473032349372 244 659771 SGTC_523 1934-0222 13.7 µM 1.72048411029831 0.0266066835166718 no 155 0.0426722397838905 337 1361595 SGTC_911 3456-4043 236 µM 1.71885881171162 0.026718460680872 no 156 0.0428200417836904 350 914281 SGTC_1699 st031318 29.054 µM 1.71821070656992 0.026763142258613 no 157 0.0428790946794581 301 5340658 SGTC_576 1073-0113 22.7 µM 1.70941486102505 0.0273757389621127 no 158 0.0436870650391304 480 5439563 SGTC_851 0394-0702 453 µM 1.70190301880476 0.0279081264548458 no 159 0.0443867748989147 330 762646 SGTC_670 4204-0025 119 µM 1.70178530788298 0.0279165371399572 no 160 0.0443978108308964 345 719039 SGTC_1476 4112-3294 3.34 µM 1.7009672806317 0.0279750451917437 no 161 0.0444745656767684 306 704369 SGTC_161 4065-0411 162.148 µM 1.69453496549289 0.0284386738130895 no 162 0.0450818366340409 407 1906281 YLR208W SEC13 SGTC_2368 9071271 200 µM 1.69407859564391 0.0284718095213948 no 163 0.0451251745237238 344 27209959 SGTC_3334 9142812 21.919 µM 1.68987395339914 0.0287786104124803 no 164 0.0455260358198213 320 45283678 SGTC_1609 st001574 46.4 µM 1.67387035192978 0.0299715944958413 no 165 0.0470780410644758 328 3960012 SGTC_392 N-ethylmaleimide 8.33 µM 1.67127530728191 0.0301688528357557 no 166 0.0473336557144281 308 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2989 9073649 71.4286 µM 1.67059530206858 0.0302207199705705 no 167 0.0474008205325057 442 21367202 SGTC_791 1348-1292 225 µM 1.66846216869732 0.0303839036831948 no 168 0.0476120079450988 422 5437054 SGTC_2325 6158266 200 µM 1.66494301933471 0.0306547123974268 no 169 0.0479620622141188 335 3623240 SGTC_1723 st034307 2.5525 µM 1.65900253627545 0.0311163830413981 no 170 0.0485576406133523 344 867466 SGTC_2641 levomentholum 100 µM 1.65476319450439 0.0314493528986409 no 171 0.0489862712890752 255 16666 SGTC_2748 diazoxide 86.69 µM 1.65337830891724 0.0315587619526791 no 172 0.0491269472908288 270 3019 A potassium channel activatior. SGTC_1970 st070122 35.8 µM 1.63772865111857 0.0328171240441875 no 173 0.0507391555318131 372 102928 SGTC_2166 5933061 31.504 µM 1.63316831889555 0.0331915001568031 no 174 0.0512168005420515 363 2877375 SGTC_399 oxolinic acid 75 µM 1.61924693616028 0.0343561793912342 no 175 0.0526970714355392 319 4628 A DNA gyrase inhibitor. SGTC_2626 ethyl orsellinate 100 µM 1.6179965051312 0.0344624157576318 no 176 0.0528316754213701 328 75653 A natural product. SGTC_175 3793-3120 23.7 µM 1.61578837284471 0.034650677305143 no 177 0.0530700381380266 346 5322297 SGTC_84 0443-0269 128.823 µM 1.60729197164699 0.0353829591463427 no 178 0.0539951673084444 379 6150058 SGTC_2337 9009472 200 µM 1.60129375928047 0.035907533522181 no 179 0.0546559353064272 425 5742383 SGTC_418 lividomycin a 100 µM 1.59872200355038 0.0361343898728173 no 180 0.0549411931240305 357 72394 An antibiotic. SGTC_2270 7924575 90.91 µM 1.59422330629153 0.0365340443947819 no 181 0.0554430141025679 377 1262135 SGTC_702 1488-0190 94 µM 1.59345734501938 0.036602449709103 no 182 0.0555288150134278 336 949357 SGTC_3024 9090631 49.47 µM 1.59336450631812 0.0366107479228409 no 183 0.0555392216722289 299 25236383 SGTC_3208 9114115 49.47 µM 1.59264210640227 0.0366753708820346 no 184 0.0556202509561161 381 650895 SGTC_2795 7780010 54.55 µM 1.59191123385034 0.0367408466903016 no 185 0.055702325515986 367 953673 SGTC_1717 st033143 58.0435 µM 1.58295515372933 0.0375509745432968 no 186 0.0567158431835883 422 674616 SGTC_1315 1237-0019 3.69 µM 1.58215035742129 0.0376244816449972 no 187 0.0568076249915116 375 825140 SGTC_2965 9082772 38.63 µM 1.57370366528895 0.0384030798260883 no 188 0.0577779870415008 402 16459634 SGTC_2113 5491891 107.031 µM 1.57163105613382 0.0385961220201612 no 189 0.0580180698671624 412 789979 SGTC_2659 sanguinarine 24.21 µM 1.56629369909698 0.0390968837624285 no 190 0.0586399377126161 376 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_314 1671-0008 2.74 µM 1.56234434917621 0.0394708142873067 no 191 0.0591034447972376 453 3913060 SGTC_862 0452-0056 10.2 µM 1.56163772548079 0.0395380243514042 no 192 0.0591866784515664 358 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_212 3807-4682 38.772 µM 1.55777557842733 0.0399070165254014 no 193 0.0596432285672408 528 3125501 YBL034C STU1 SGTC_700 3453-2283 142 µM 1.55423902763439 0.0402473513086044 no 194 0.0600637056688276 449 565664 SGTC_2602 kawain 100 µM 1.55233770389595 0.0404312945743649 no 195 0.0602907204051248 441 5369129 SGTC_14 0354-0009 295 µM 1.55195627522026 0.0404682779100143 no 196 0.0603363430965825 396 1713507 SGTC_697 0508-1955 564 µM 1.55088420084503 0.0405723733799584 no 197 0.0604647186367255 429 6243113 SGTC_969 1313-0238 134 µM 1.55068267026913 0.0405919656922498 no 198 0.0604888747611794 449 5212874 SGTC_2625 euphol 100 µM 1.54881181035987 0.0407742129264376 no 199 0.0607134828072051 446 6708538 A triterpene alcohol. SGTC_1795 st049545 62.3 µM 1.5485262625059 0.0408020874877102 no 200 0.0607478218578379 376 5291882 SGTC_946 3434-1334 87.4 µM 1.54318002863256 0.0413268357829116 no 201 0.061393550780295 398 4047976 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.54282701774426 0.0413616764610365 no 202 0.0614363761398113 383 2724278 An inhibitor of dopamine biosynthesis. SGTC_2551 apiole 73.87 µM 1.52895400580553 0.0427498418020676 no 203 0.063137923243106 250 10659 A possible DNA adduct former. SGTC_1034 k072-0165 12.7 µM 1.5244373252195 0.0432098338772825 no 204 0.063699751038956 436 5835461 SGTC_2953 9074162 66.49 µM 1.52281706732997 0.0433758167166341 no 205 0.0639022393782892 358 16451992 SGTC_2226 7298446 200 µM 1.5157329514022 0.0441075843984968 no 206 0.0647934459906158 345 3283010 SGTC_2212 7123476 200 µM 1.51322055506334 0.0443694859507818 no 207 0.0651118223434056 311 1085715 SGTC_1119 parthenolide 318.541 nM 1.50733351293508 0.0449880829557317 no 208 0.0658625957785138 509 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2563 tomatine 8.54 µM 1.50517859614335 0.0452162449405319 no 209 0.0661390832341262 500 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2588 indole-3-carbinol 100 µM 1.50415061694384 0.0453254146061839 no 210 0.0662712948705928 470 3712 Induces cell cycle arrest. SGTC_1334 1486-0610 236 µM 1.50343991259357 0.045401014103226 no 211 0.0663628203974203 436 3742339 SGTC_967 1306-0166 352 µM 1.50246491511643 0.0455048921201668 no 212 0.0664885411780194 432 4437607 SGTC_383 2324-0395 7.37 µM 1.49996414615944 0.0457722025373808 no 213 0.0668118450969554 444 3146421 SGTC_2667 digitoxin 100 µM 1.49973346661931 0.0457969236164253 no 214 0.0668417289327026 307 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1678 st019265 80.2 µM 1.49320360142094 0.0465011671903416 no 215 0.0676919498434733 463 5367020 SGTC_449 xestospongin c 11.1929 µM 1.49280393074978 0.0465445522631523 no 216 0.0677442590421273 449 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1875 nocodazole 6 µM 1.48983717497505 0.0468676161304152 no 217 0.0681335269139051 415 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2041 5107442 45.335 µM 1.48827478175549 0.0470384740074907 no 218 0.0683392213560458 433 793005 SGTC_1196 1588-0294 184 µM 1.48731753317389 0.0471434018697107 no 219 0.0684654829527036 393 6144269 SGTC_1368 1852-0141 284 µM 1.48632345901499 0.0472525648496967 no 220 0.0685967922690248 431 2838987 SGTC_2564 betulinic acid 100 µM 1.48260485336458 0.047662716325578 no 221 0.0690897134557592 484 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_361 000s-0510 1.45 µM 1.48225361864891 0.047701603423267 no 222 0.0691364122319546 453 660 SGTC_1458 k015-0034 6.33 µM 1.47757248676412 0.0482223065332497 no 223 0.0697611215478955 409 3598957 SGTC_2518 prenyletin 46.28 µM 1.47170024052026 0.0488819218673054 no 224 0.0705509213170587 333 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2891 9063876 19.48 µM 1.47069453181728 0.0489956104850454 no 225 0.0706868728423348 333 6472478 SGTC_2519 cryptotanshinone 88.04 µM 1.46773862867098 0.049330978686356 no 226 0.0710876168045519 394 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1921 5740136 50 µM 1.45529185598614 0.050763307053014 no 227 0.0727942401478644 492 1774243 SGTC_2747 doxorubicin 7.63 µM 1.45484823471756 0.0508149621678206 no 228 0.0728556406649832 270 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2629 bisabolol 100 µM 1.44983446422138 0.0514016778584163 no 229 0.0735523431271439 476 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1312 1218-2183 165 µM 1.43922484336029 0.0526609847628083 no 230 0.0750434143765036 461 6744073 SGTC_366 0181-0206 4.31 µM 1.43690810617843 0.0529391997860841 no 231 0.0753720531518678 483 274874 SGTC_2453 5731132 22.18 µM 1.42981209368259 0.0537986127514871 no 232 0.0763854785714132 490 1362040 SGTC_1776 st049249 45.9 µM 1.41548725843501 0.0555671631907721 no 233 0.0784628408058509 485 1822314 SGTC_462 ag-879 158 µM 1.41401698055039 0.0557512515489744 no 234 0.0786784584075566 513 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1478 0453-0656 35.7 µM 1.41332984383678 0.0558374503876985 no 235 0.0787793814733316 469 5258496 SGTC_1499 4480-0877 67.3 µM 1.41191845086445 0.0560148343652301 no 236 0.0789869871464167 405 2861909 SGTC_1096 rimcazole 32.2 µM 1.41177618845202 0.0560327385460421 no 237 0.0790079358836165 425 18528119 A dopamine reuptake inhibitor. SGTC_2421 5690543 90.72 µM 1.40999029788852 0.0562578827767743 no 238 0.0792712738684147 474 3397993 SGTC_2793 7325131 81.82 µM 1.40832350679362 0.0564686552138604 no 239 0.0795176490617264 425 4176441 SGTC_904 1141-0088 396 µM 1.40322578154394 0.0571171469258217 no 240 0.0802747609432489 467 1378119 SGTC_1424 4048-1941 275 µM 1.39932696067779 0.0576170686758948 no 241 0.0808574791897455 501 X1424 SGTC_1036 k216-0215 33.5 µM 1.39724611619091 0.0578852874328238 no 242 0.0811697866371461 548 622330 SGTC_2014 4013930 200 µM 1.39631949997144 0.0580050427408478 no 243 0.0813091521222347 540 64556 SGTC_2125 5246583 200 µM 1.39602603453648 0.0580430106040756 no 244 0.0813533277017209 554 835267 SGTC_1319 1306-0155 43.7 µM 1.39368818161003 0.0583461743984762 no 245 0.0817058933145135 545 3122360 SGTC_743 1275-0778 158 µM 1.39315240253816 0.0584158270389003 no 246 0.0817868547810441 510 2849257 YMR203W TOM40 SGTC_2055 5235184 200 µM 1.39245965447699 0.0585059828269459 no 247 0.0818916254183308 491 2836034 SGTC_2777 climbazole 1.536 µM 1.3817523016865 0.0599133998433017 no 248 0.083523884615808 525 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1503 4585-0012 61.3 µM 1.37143690357861 0.061294243041737 no 249 0.0851194000268404 462 2922052 SGTC_861 0443-0273 110 µM 1.37010708738531 0.061474050244123 no 250 0.0853267378815064 495 6149169 SGTC_1327 1436-0082 2.18 µM 1.36894151201139 0.0616319886687748 no 251 0.085508779118791 483 15992205 SGTC_802 4112-3352 742 µM 1.36686612254019 0.0619139933562157 no 252 0.0858336361912332 560 704594 SGTC_2425 5628681 7.85 µM 1.36638063475609 0.0619801067341633 no 253 0.085909761887452 595 5714958 SGTC_2522 biochanin a 4.94 µM 1.36587966393104 0.0620483863228563 no 254 0.0859883683211179 450 5280373 A possible chelator. SGTC_1140 3229-1848 2.98 µM 1.36557876042099 0.0620894260328596 no 255 0.0860356084149833 472 2849525 SGTC_739 1486-1183 203 µM 1.35774168754559 0.0631657871249667 no 256 0.0872728319404464 526 4346692 SGTC_2094 5332512 191.667 µM 1.35672783389655 0.0633060871136072 no 257 0.0874338525309939 526 755774 SGTC_1246 0422-0085 105 µM 1.35378320047792 0.0637149497267375 no 258 0.087902777428862 568 264295 SGTC_2804 7954240 19.48 µM 1.3469427496062 0.0646726746018996 no 259 0.0889993359260815 547 828705 SGTC_2499 avocadenofuran 51.48 µM 1.34516560961395 0.0649233108429946 no 260 0.0892858796823877 530 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_808 0711-0032 135 µM 1.34363698495916 0.0651395007771314 no 261 0.0895329017840437 492 4252555 SGTC_290 2043-6722 48.1 µM 1.33925078774034 0.0657629324466146 no 262 0.0902445218480716 519 773758 YLR208W SEC13 SGTC_1735 st034310 56.75 µM 1.33894845077004 0.0658060748841682 no 263 0.0902937275625995 524 871153 SGTC_1615 st002656 86.5 µM 1.32700243551252 0.0675283489539261 no 264 0.0922539385054287 509 1584458 SGTC_2556 citropten 84.59 µM 1.321757759056 0.0682953970526995 no 265 0.0931244142044891 583 2775 A potential DNA crosslinker. SGTC_2254 7938975 95.19 µM 1.32139751104546 0.0683483300761674 no 266 0.0931844277599182 644 2969277 SGTC_541 4513-1321 94 µM 1.31931563809228 0.0686548502849945 no 267 0.0935318059546556 527 747515 SGTC_1663 st014140 55.4 µM 1.31878632985157 0.0687329506575921 no 268 0.0936202778269307 608 4207120 SGTC_2026 5148700 152 µM 1.31505710092406 0.0692851480911604 no 269 0.0942453563379478 553 79838 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.31339843333339 0.0695318470422171 no 270 0.0945243625762385 486 279621 SGTC_118 0083-0097 135.343 µM 1.31127319737835 0.0698489280847318 no 271 0.0948827401369223 776 5207356 SGTC_1764 st044502 93.5 µM 1.30963660894149 0.0700938613998904 no 272 0.0951593988470026 544 8407 SGTC_247 mechlorethamine 29.705 µM 1.3059603457234 0.0706464628264417 no 273 0.0957830215379481 473 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2533 agelasine 13.65 µM 1.30508952565392 0.0707778502571466 no 274 0.0959311824884828 580 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_520 3584-0023 682 µM 1.29883784545267 0.0717266085473826 no 275 0.0969997918481674 524 1340790 SGTC_2583 asiatic acid 100 µM 1.29835285679634 0.0718006164959737 no 276 0.0970830554942385 515 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1171 0368-0077 21.4 µM 1.29782096982205 0.0718818483217073 no 277 0.0971744310198264 507 3239779 SGTC_2004 4023728 41.89 µM 1.29257359097775 0.0726870297388043 no 278 0.098079289186676 569 360084 YDR527W RBA50 SGTC_798 1287-0182 476 µM 1.29201448310804 0.0727732273231074 no 279 0.0981760645025102 606 1649755 SGTC_940 3232-1287 54.8 µM 1.2912129737096 0.072896932410922 no 280 0.0983149188009929 559 1585493 YIL048W NEO1 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.28760112150626 0.0734563841814105 no 281 0.0989424243758483 570 5282309 SGTC_891 0929-0073 133 µM 1.28743036533676 0.0734829142323241 no 282 0.0989721630899582 552 5603632 SGTC_761 k216-0224 480 µM 1.28625970573889 0.0736649946718099 no 283 0.0991762200272582 601 1340404 SGTC_1579 chlormadinone acetate 49.4 µM 1.28320908763025 0.0741410979170214 no 284 0.0997094165099486 560 45114258 A steroidal progestin. SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.28229476859358 0.0742842505035484 no 285 0.0998696312115516 537 140250 A respiratory chain inhibitor. SGTC_1861 st057647 17.4 µM 1.27890558332449 0.0748167283017903 no 286 0.100465153136378 580 688668 SGTC_1500 4488-1866 171 µM 1.27806903208395 0.074948606607085 no 287 0.100612543464601 608 2900003 SGTC_2507 purpurin 79.67 µM 1.27527072784086 0.0753910346344466 no 288 0.101106717407497 579 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1405 3909-7894 12 µM 1.2750262288655 0.0754297856937406 no 289 0.101149979239383 565 7104060 SGTC_580 1123-0028 41 µM 1.27360601226959 0.0756551784874979 no 290 0.101401540213746 628 1677248 YPR107C YTH1 SGTC_1671 st016596 74.5 µM 1.27251030960821 0.0758294202580822 no 291 0.101595931699522 606 2829167 SGTC_1220 1838-0075 193 µM 1.27232798502 0.0758584436713168 no 292 0.10162830470058 577 5529645 SGTC_2876 9059903 25.97 µM 1.26939363461118 0.0763267139150894 no 293 0.102150352665503 602 6916095 SGTC_1154 4088-0362 150 µM 1.26801664976191 0.0765472130975214 no 294 0.102396002391209 641 6618304 SGTC_458 nppb 133 µM 1.26615899688748 0.076845449885391 no 295 0.102728082042022 540 4549 A chloride channel blocker. SGTC_711 k292-0785 179 µM 1.26514219479936 0.0770090659901031 no 296 0.102910179777459 563 4146315 SGTC_2982 9019404 25.97 µM 1.26508271972267 0.0770186444599556 no 297 0.102920838345161 475 22333232 SGTC_1805 st050013 60.3 µM 1.26317337429391 0.0773266261850548 no 298 0.103263439669989 536 4037144 SGTC_3017 9080681 49.47 µM 1.2619601885765 0.0775228012754263 no 299 0.10348155611411 555 16451914 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.26104249048122 0.0776714461855218 no 300 0.103646769376225 424 88881 An O-methylated flavonoid and antioxidant. SGTC_543 3844-1095 191 µM 1.2607643740177 0.0777165370268434 no 301 0.103696876475265 606 4230703 SGTC_1831 st055328 12 µM 1.2563715732935 0.0784313770477812 no 302 0.104490641552534 596 1103068 SGTC_2946 9065502 71.43 µM 1.25073558116559 0.0793558084851436 no 303 0.105515482200227 409 16489101 SGTC_2207 7258803 200 µM 1.2497981830517 0.0795103598829953 no 304 0.10568663999759 515 3666799 SGTC_738 1315-0003 72.4 µM 1.24695508872464 0.0799805017451818 no 305 0.106206982801242 619 6251474 SGTC_2324 6149169 200 µM 1.24650336606934 0.0800553929580988 no 306 0.106289827104793 547 2888231 SGTC_1701 st028638 40.4 µM 1.24559495462569 0.0802061592127295 no 307 0.106456567759341 576 3490878 SGTC_3039 9090270 49.47 µM 1.24471133782708 0.0803530161782561 no 308 0.106618938426236 544 17173750 SGTC_281 1672-3440 14.9 µM 1.24336572132922 0.0805770475990872 no 309 0.106866547980191 635 6833000 SGTC_2347 9049783 174.81 µM 1.23957165335053 0.0812112616050788 no 310 0.107566935378671 641 6467988 YPL169C MEX67 SGTC_652 0437-0092 114 µM 1.23947071466592 0.0812281857384063 no 311 0.107585613789085 556 3091274 SGTC_1007 4101-0031 70 µM 1.23403817086015 0.082142977232911 no 312 0.108594340485519 614 1146276 SGTC_2114 5491910 81.25 µM 1.23308746188306 0.0823038628733355 no 313 0.108771567392765 604 2849228 SGTC_1923 st058458 19.1 µM 1.23174712283307 0.0825310874028612 no 314 0.109021780553549 649 3534982 SGTC_1645 Cervolide 78 µM 1.23030006409756 0.0827769336517891 no 315 0.109292380166385 541 23173 A fragrance. SGTC_1351 1496-0003 46.5 µM 1.22861892119363 0.083063240840082 no 316 0.109607358969878 619 3891978 SGTC_2463 5473429 200 µM 1.22822968728559 0.083129635409341 no 317 0.109680378635964 584 5399405 SGTC_1128 3448-9350 235 µM 1.22769064724116 0.0832216494374874 no 318 0.10978155935839 541 619386 SGTC_803 4488-1585 147 µM 1.22593690351661 0.0835215430058396 no 319 0.110111210043843 598 747204 SGTC_1139 k015-0024 46.9 µM 1.22149558792982 0.0842846482406497 no 320 0.110949217556573 598 2766652 SGTC_657 3534-0529 86.7 µM 1.2172938105038 0.0850114017328714 no 321 0.111746224204678 588 1049549 SGTC_1353 1498-1206 8.11 µM 1.21580581576839 0.0852698933445793 no 322 0.112029451422268 687 6756808 SGTC_2263 7948595 193.29 µM 1.21434696601068 0.0855238931836213 no 323 0.11230762902215 541 2971371 SGTC_57 miconazole 162.5 nM 1.21065263365344 0.0861696457838013 no 324 0.1130142814862 590 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_280 3448-3607 3.04 µM 1.20262062499736 0.0875861783936265 no 325 0.114561581298949 622 626179 SGTC_2663 amphotericin b 100 µM 1.19998813859739 0.0880542065896879 no 326 0.115071973557079 568 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2077 5212015 200 µM 1.19804413525527 0.0884010249270579 no 327 0.115449917691297 587 780900 SGTC_819 1013-0258 27.7 µM 1.19792643216579 0.0884220562848858 no 328 0.115472829269009 613 5753198 SGTC_871 0574-0004 149 µM 1.19516434446418 0.0889166609422771 no 329 0.116011413152671 663 9551173 SGTC_2886 9058944 51.95 µM 1.19261832407465 0.0893743962425632 no 330 0.116509443050093 447 4949929 SGTC_689 0833-0039 98 µM 1.19208922087773 0.0894697404571885 no 331 0.116613131549279 650 5374726 SGTC_1467 k284-1082 293 µM 1.19165583403289 0.0895478929610067 no 332 0.116698111227189 676 3334705 SGTC_1115 galangin 695.678 nM 1.1903031671862 0.0897921454136994 no 333 0.116963628203107 687 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2638 epoxomicin 18 µM 1.1882714628786 0.0901599423972788 no 334 0.11736323843805 662 9915668 A protesome inhibitor. SGTC_2111 5486399 200 µM 1.18785818957463 0.0902348935503854 no 335 0.117444642207618 698 689674 SGTC_1120 ficusin 1.78878 µM 1.18498592427301 0.0907570859208015 no 336 0.118011506118844 649 6199 A DNA cross-linker. SGTC_2252 omeprazole 400 µM 1.18245837321109 0.0912184596033715 no 337 0.118511936586883 523 4594 A proton pump inhibitor. SGTC_1871 st057448 67.3 µM 1.18050712005171 0.0915758249574436 no 338 0.118899290151765 666 691747 SGTC_2763 lisinopril 49.32 µM 1.17989620692816 0.0916879245943002 no 339 0.11902074933324 589 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1291 0993-0025 5.79 µM 1.17788881901325 0.092056986554851 no 340 0.119420466560301 649 4353356 SGTC_261 5-fluorouridine 15.376 µM 1.17535799054408 0.092523850106286 no 341 0.119925761469454 655 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1271 0832-2808 169 µM 1.17037590929965 0.0934480118730454 no 342 0.120924863011761 674 3663794 SGTC_1181 1222-0449 220 µM 1.1698569288209 0.0935446719933395 no 343 0.121029274689312 660 658318 SGTC_546 peri-Naphthalide 147 µM 1.16871180296626 0.093758212864975 no 344 0.121259882470239 651 223824 A penicillin ester. SGTC_2650 prasterone 100 µM 1.16795573447989 0.0938994001675272 no 345 0.121412310346319 549 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_109 0132-0036 33.701 µM 1.16724376606002 0.0940324956738075 no 346 0.121555970496546 514 67274 A color developer. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.16613149105709 0.094240703092322 no 347 0.12178064309469 593 17037758 SGTC_468 gf-109203x 121 µM 1.16413000348368 0.0946162188960419 no 348 0.122185665613326 502 2396 A protein kinase C inhibitor. SGTC_464 bw-b 70c 158 µM 1.15761260853756 0.0958466441624149 no 349 0.123511080769039 716 5353454 SGTC_1370 2001-0092 44.6 µM 1.15690396771474 0.0959811353167347 no 350 0.123655798751857 763 790957 SGTC_968 1309-0633 340 µM 1.1556238369192 0.0962244398063269 no 351 0.123917526784064 645 3761976 SGTC_2928 9011484 9.79 µM 1.1512389756121 0.097061272083127 no 352 0.12481696737314 606 2994751 SGTC_2861 9024595 19.48 µM 1.15053624119356 0.0971958811225794 no 353 0.124961538175213 546 16482810 SGTC_1311 1190-0148 100 µM 1.14988425149902 0.0973208924548932 no 354 0.125095774038037 772 1961333 SGTC_467 ro 31-8220 72.8 µM 1.14984759164344 0.0973279250509675 no 355 0.125103324796003 696 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1167 k781-0610 148 µM 1.14786874457453 0.0977080880463045 no 356 0.125511376396998 707 4525169 SGTC_2213 7173844 200 µM 1.14771216797214 0.0977382149209466 no 357 0.12554370315679 699 892728 SGTC_2515 chrysin 20.77 µM 1.14607019272356 0.0980545573230401 no 358 0.125883054855322 675 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2034 5197015 53.07 µM 1.14593093788733 0.0980814205843271 no 359 0.125911864448497 675 780676 SGTC_2461 5755302 26.15 µM 1.13715046500872 0.0997861432906386 no 360 0.127737695252977 706 2788904 SGTC_2620 irigenin 100 µM 1.13501983726076 0.100203047262976 no 361 0.128183503410366 685 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2753 fluvastatin 17.09 µM 1.13116334014699 0.100960886286619 no 362 0.128993174364359 687 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2813 7971799 71.43 µM 1.12990742890082 0.101208584669166 no 363 0.129257616653211 655 2234054 SGTC_2899 9053889 58.44 µM 1.12965581544129 0.101258262592596 no 364 0.129310641055585 656 6470052 SGTC_2506 ethyl hematommate 54.16 µM 1.12629098317955 0.10192431479332 no 365 0.13002118656163 611 3940691 An allergen. SGTC_858 0438-0351 2.77 µM 1.12543948121655 0.102093369873753 no 366 0.130201424348956 728 2799119 SGTC_2544 sphondin 68.51 µM 1.12415513897746 0.102348745762958 no 367 0.130473608532006 648 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3237 9133362 49.47 µM 1.12109450645003 0.102959187371266 no 368 0.131123818412603 680 43845137 SGTC_2970 9090938 41.86 µM 1.11914015695571 0.10335036255414 no 369 0.13154017528819 769 17217104 SGTC_496 calpeptin 138 µM 1.11817959281359 0.103543020416862 no 370 0.131745149111237 589 73364 A calpain inhibitor. SGTC_2685 mycophenolic acid 18.85 µM 1.11692270167779 0.103795505276743 no 371 0.132013688552581 657 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1889 st059080 5.18 µM 1.1136191817697 0.104461246696204 no 372 0.132721296899813 752 176925 Isolated from Daphnopsis sellowiana. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.11297384495152 0.104591658536258 no 373 0.132859831385236 728 165521 SGTC_2164 5685496 200 µM 1.1128465179868 0.104617403122708 no 374 0.132887176427279 729 759046 SGTC_1740 st038286 13.222 µM 1.11057288616208 0.105077887959453 no 375 0.13337611948754 686 716786 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.11012792477171 0.105168178579454 no 376 0.133471952763457 780 551469 SGTC_910 3454-3003 490 µM 1.10968890473493 0.105257318603919 no 377 0.133566552829859 711 820824 SGTC_273 hydroxyurea 18.1 mM 1.10564722198642 0.106080523890874 no 378 0.134439621103101 773 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3355 9151058 44.0485 µM 1.10370352640895 0.10647806579463 no 379 0.134860882710988 687 17015728 SGTC_2710 st078562 53.7235 µM 1.10149727632916 0.106930609754038 no 380 0.13534014462669 695 17250908 SGTC_316 k060-0003 58.6 µM 1.10076857256687 0.107080385185826 no 381 0.135498696513373 694 6152314 SGTC_2063 5246145 200 µM 1.1001168394613 0.107214468438655 no 382 0.135640608851062 730 711240 SGTC_3336 9143619 71.43 µM 1.09938438050451 0.107365304127111 no 383 0.135800220405248 765 45595730 SGTC_1648 st011736 69.8 µM 1.09389805839118 0.108499971367314 no 384 0.136999845209914 691 2855514 SGTC_2311 7694451 200 µM 1.09378395885854 0.108523660368417 no 385 0.137024870540907 704 2163142 SGTC_1997 st073024 93.8 µM 1.09273681249144 0.108741239520464 no 386 0.13725468593173 706 686268 SGTC_356 1634-0012 32.5 µM 1.09193146302013 0.108908790678276 no 387 0.137431613573746 745 735457 SGTC_622 1348-1566 26.3 µM 1.09074746736344 0.109155455202532 no 388 0.137692008834659 767 7340407 SGTC_563 tetrahydrosecaminediol 614 µM 1.0898482304947 0.109343063326104 no 389 0.137890002146883 752 334274 A psychoactive constituent of the cannabis plant. SGTC_2898 9056270 58.44 µM 1.08937891274784 0.109441069202707 no 390 0.137993413281221 638 19154699 SGTC_2054 5233173 129 µM 1.0861096555801 0.110125526815842 no 391 0.138715240504102 761 6889 SGTC_1397 3532-0190 20.1 µM 1.0860905644207 0.110129532773636 no 392 0.138719463226812 645 5322280 SGTC_250 brefeldin a 552.239 µM 1.0847324385612 0.110414780857334 no 393 0.139020088154573 614 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3226 9131256 49.47 µM 1.0842126770581 0.110524086751151 no 394 0.139135256066014 616 17178073 SGTC_1132 3456-3614 2.5 µM 1.08419613453047 0.110527566919526 no 395 0.139138922598422 820 3125502 SGTC_3176 9106582 49.47 µM 1.08381138058016 0.110608532487238 no 396 0.139224219099492 559 17018027 SGTC_817 1391-0715 46 µM 1.08369634950752 0.110632747264732 no 397 0.13924972736496 676 1353946 SGTC_1948 st076329 66.6 µM 1.0793040378283 0.111560200951275 no 398 0.140226106739778 668 24208413 SGTC_1955 wogonin 32.4 µM 1.07810675426021 0.111813974207366 no 399 0.140493058878692 704 5281703 A flavanone. SGTC_512 prima-1 270 µM 1.07626464694266 0.112205228558734 no 400 0.140904457427278 749 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3297 9117502 71.43 µM 1.07409749217378 0.112666772880384 no 401 0.141389494220778 746 7453720 SGTC_2313 7726885 200 µM 1.07195345601188 0.113124726177512 no 402 0.141870469103739 707 726423 SGTC_1451 4152-0210 104 µM 1.07165147855154 0.113189333315988 no 403 0.141938301071376 749 659563 SGTC_1098 clofazimine 15.1 µM 1.06863344286686 0.113836479306436 no 404 0.142617436487287 774 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1301 naphtanilide LB 4.81 µM 1.06740476639344 0.114100693578363 no 405 0.14289454852782 799 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_222 nsc-310342 10.666 µM 1.06700224264157 0.114187347102166 no 406 0.142985411621961 642 432556 SGTC_1590 st077108 57.8 µM 1.06685724658588 0.114218572687916 no 407 0.14301815165126 730 5489485 SGTC_3094 9117742 49.47 µM 1.0668194977786 0.114226703069527 no 408 0.143026676142054 775 17149698 SGTC_1698 5-fluorocytosine 1.055 µM 1.06671452874356 0.114249313587753 no 409 0.14305038220744 740 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2019 4016004 108 µM 1.06406392286737 0.114821315525944 no 410 0.143649871390163 661 45595336 SGTC_98 0074-0023 107.663 µM 1.06060038112125 0.115571815692392 no 411 0.144435774646269 777 3563821 SGTC_2048 5246248 200 µM 1.06015105595802 0.11566943285769 no 412 0.144537941771544 722 677046 SGTC_2834 9001755 58.44 µM 1.05964235213298 0.115780020877979 no 413 0.144653669113913 674 2989575 SGTC_1627 st003713 25.6 µM 1.05791991950622 0.116155021021299 no 414 0.14504597647755 796 16195070 YER133W GLC7 SGTC_2327 6189656 200 µM 1.05630157987188 0.116508143210856 no 415 0.145415227206899 740 5349088 SGTC_3018 9082602 49.47 µM 1.05549845683095 0.11668366730907 no 416 0.145598707446256 769 17332089 SGTC_2691 st077356 60.2 µM 1.05494029199285 0.116805765700848 no 417 0.145726316564985 776 2839272 SGTC_1793 st048256 72.231 µM 1.0548402690332 0.116827655259324 no 418 0.145749192019283 740 672022 SGTC_1039 k821-0043 94 µM 1.05270917356479 0.117294726698779 no 419 0.146237151483358 775 15992768 SGTC_1808 st050063 61.5 µM 1.05225393842293 0.117394671624339 no 420 0.146341529265245 747 4011993 SGTC_1799 st045822 46.1415 µM 1.05167043534102 0.117522865395102 no 421 0.146475389867992 737 3674992 SGTC_100 0086-0128 49.5915 µM 1.05088928739725 0.117694636216137 no 422 0.146654720526599 786 93297 SGTC_949 1165-0505 146 µM 1.05044212371296 0.117793045378479 no 423 0.146757443621289 803 6244267 SGTC_668 1682-0499 62.6 µM 1.04934662263702 0.118034382858219 no 424 0.147009307685863 798 682214 SGTC_2269 7935389 174.42 µM 1.04870058039229 0.118176868971275 no 425 0.147157973526374 719 97605 SGTC_2383 9036125 200 µM 1.04785301541676 0.118363985791841 no 426 0.14735316614344 725 79580 SGTC_451 chloral hydrate 100 µM 1.04637404442353 0.118690999450999 no 427 0.147694185743362 812 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3119 9125183 49.47 µM 1.04592298303623 0.118790860043954 no 428 0.147798296110113 603 22695334 SGTC_959 1222-0044 107 µM 1.04506908751022 0.118980066675718 no 429 0.147995519952834 762 6083612 SGTC_564 3555-0129 330 µM 1.04121028653769 0.119837755385072 no 430 0.148888981326667 683 563260 SGTC_385 1494-0393 12.4 µM 1.04093564497342 0.119898965213976 no 431 0.148952708550812 782 3090647 SGTC_3168 9103419 49.47 µM 1.03798842016501 0.120557205754465 no 432 0.149637723115937 687 16649256 SGTC_1426 4048-4480 71.7 µM 1.03508419688582 0.121208327337133 no 433 0.150314796046542 790 14224343 SGTC_2439 5492030 7.2 µM 1.03485944261072 0.121258819751235 no 434 0.150367278863912 743 5722370 SGTC_3329 9141233 27.5565 µM 1.0310692131173 0.122112546603061 no 435 0.151254181939513 755 4909101 YNL103W MET4 SGTC_2682 pyrogallin 40.03 µM 1.02978613196147 0.122402507014769 no 436 0.151555206089552 826 822798 An ATP competetive kinase inhibitor. SGTC_1146 3579-1023 7 µM 1.02962686124569 0.122438533904709 no 437 0.15159260042004 856 X1146 SGTC_3139 9095020 49.47 µM 1.02935841635417 0.122499272732683 no 438 0.151655641058128 608 25236292 SGTC_1379 2144-0755 36.5 µM 1.02760190624339 0.122897225681807 no 439 0.152068563581666 823 5392327 SGTC_2852 9023854 51.95 µM 1.02736356872488 0.122951292926265 no 440 0.152124649731196 788 19798528 SGTC_2352 9027995 87.8 µM 1.02667199329903 0.12310827230433 no 441 0.152287470648094 717 2997347 SGTC_2859 9028643 45.46 µM 1.02293020382373 0.12396005005322 no 442 0.153170423757615 746 17151580 SGTC_1587 estradiol valerate 56.1 µM 1.02279246264903 0.123991483850549 no 443 0.153202991268467 792 13791 A steroid. SGTC_1976 st070609 63.5 µM 1.0221608859148 0.124135686869509 no 444 0.153352379969113 802 682556 SGTC_1811 st050069 61.5 µM 1.02197099676349 0.124179065719743 no 445 0.153397313870881 764 3877702 SGTC_674 0498-0004 451 µM 1.02110640852588 0.124376708920026 no 446 0.153602013601229 749 4231473 SGTC_1346 1488-2224 62.4 µM 1.01773571847857 0.125149342281732 no 447 0.154401783929833 798 3722427 SGTC_3203 9113543 49.47 µM 1.01696268510027 0.125327009341886 no 448 0.154585590507494 732 17018012 SGTC_552 k242-0005 476 µM 1.01215468415397 0.126435990431953 no 449 0.155732049696838 768 4088318 SGTC_1194 1488-0194 225 µM 1.01030573430371 0.126864271440241 no 450 0.156174417340959 815 1391452 SGTC_2232 chlorophetanol 41.5365 µM 1.00936174663777 0.127083320783538 no 451 0.156400588595587 915 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3230 9131665 49.47 µM 1.00706193717373 0.127618085550835 no 452 0.156952505482697 679 15943720 SGTC_942 3253-1115 227 µM 1.00576437394351 0.127920491703648 no 453 0.157264464272169 803 46497897 SGTC_1815 st051655 58.2 µM 1.00485366558078 0.128133035774305 no 454 0.157483659124704 787 5984156 SGTC_2745 rifampicin 24.3 µM 1.00370447013667 0.128401588605368 no 455 0.157760540898835 658 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1051 3253-3903 78 µM 1.00229809187139 0.12873077327066 no 456 0.158099821926833 820 5509239 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.00219268000716 0.128755470120581 no 457 0.158125271239963 788 616764 SGTC_565 1418-0001 44.5 µM 0.99990692694633 0.129291805683397 no 458 0.158677775933734 852 2862145 SGTC_3183 9108214 49.47 µM 0.993700789435153 0.130755833856329 no 459 0.160184279149619 721 4974831 SGTC_2148 5546263 113.568 µM 0.991534208633684 0.131269618577061 no 460 0.160712398473601 798 792097 SGTC_2977 9011197 71.43 µM 0.990668879160431 0.13147521260947 no 461 0.160923646021677 738 2704722 SGTC_269 exalamide 29 µM 0.989713530940403 0.131702452289884 no 462 0.16115707971242 798 3316 A derivative of salicylamide. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.984789509632303 0.13287798025141 no 463 0.162363737277942 862 165506 SGTC_1895 st058434 18.3 µM 0.984147847331236 0.133031696833528 no 464 0.162521412022314 847 5393175 SGTC_1335 1486-0900 202 µM 0.982097057395759 0.133523804525174 no 465 0.163026017511807 836 X1335 SGTC_3084 9116877 49.47 µM 0.981841196178735 0.133585288728034 no 466 0.163089044622368 770 27241325 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.981661149678594 0.133628566099972 no 467 0.163133405543874 775 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_179 1273-0063 6.77 µM 0.981616359991986 0.133639333593372 no 468 0.163144442309702 772 3108139 SGTC_1480 1070-0044 41.2 µM 0.980331364864064 0.133948502023746 no 469 0.163461288613627 828 3124987 SGTC_1278 0874-0585 172 µM 0.980326865447795 0.133949585441231 no 470 0.16346239875409 825 766306 SGTC_1568 digitonin 820 nM 0.978824300143146 0.134311725982056 no 471 0.163833400374858 872 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_632 0781-2353 4.65 µM 0.977349397866587 0.13466785267457 no 472 0.164198102722203 835 6811515 YHR007C ERG11 SGTC_2408 sulbentine 18.36 µM 0.97710412601311 0.134727138268164 no 473 0.164258802655306 808 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_604 1000-0114 314 µM 0.973332413325402 0.135641068870948 no 474 0.165194058920481 892 1572745 SGTC_332 4112-0506 40.9 µM 0.969496518611219 0.136574898408902 no 475 0.166148758188942 835 2790355 SGTC_2073 5212005 126 µM 0.96768867884138 0.137016528840417 no 476 0.166599936920411 747 691789 SGTC_1399 3562-5772 25 µM 0.96571733444099 0.137499212255818 no 477 0.167092821550392 762 23847490 SGTC_24 0417-1663 219 µM 0.963749083524853 0.137982295060351 no 478 0.167585869751796 813 4329390 SGTC_1125 tnp00248 1.32998 µM 0.963735301157187 0.137985681848216 no 479 0.167589325545061 962 24207736 SGTC_842 0271-0008 11.1 µM 0.960062800205044 0.138890158885368 no 480 0.168511804626996 881 1221709 SGTC_186 3455-3465 67.277 µM 0.959258548769977 0.139088770511636 no 481 0.168714255875627 787 755278 SGTC_3303 9125618 40.5795 µM 0.958467125133824 0.139284402918726 no 482 0.16891363055979 901 22695467 SGTC_1212 0520-0165 585 µM 0.956464158396551 0.139780353492792 no 483 0.169418891977603 816 5403258 SGTC_421 streptovitacin 30 mM 0.956147980340576 0.139858751278276 no 484 0.169498738501473 875 91467 include heat shock SGTC_330 1488-0319 80.1 µM 0.954831308447784 0.140185547388233 no 485 0.169831505908543 840 6846614 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.954587052767451 0.140246228294947 no 486 0.169893283592837 840 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1996 st072960 66.8 µM 0.953131351156677 0.140608241001539 no 487 0.170261761604626 881 1719405 SGTC_1513 0337-0559 19 µM 0.950856148317831 0.141175321596107 no 488 0.170838702533034 782 775073 SGTC_533 1222-0222 6.71 µM 0.94964555004194 0.141477687121208 no 489 0.171146192691567 898 3982874 SGTC_3125 9127534 49.47 µM 0.946454797795408 0.142276727884114 no 490 0.171958333585391 764 1639235 SGTC_3152 9099253 49.47 µM 0.9453775640809 0.142547181137632 no 491 0.172233076116818 926 25236131 SGTC_259 usnic acid 108.925 µM 0.945166644002737 0.142600175986364 no 492 0.172286902894862 876 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3043 9092303 49.47 µM 0.943956997617429 0.142904363687942 no 493 0.172595811759173 809 25236084 SGTC_1804 st050076 49.1 µM 0.943726528232482 0.142962369127007 no 494 0.172654707033969 854 3895976 SGTC_2402 5553605 200 µM 0.941294784693602 0.143575369434253 no 495 0.173276907326904 890 6758546 SGTC_716 1683-5115 658 µM 0.939892600755676 0.143929640921641 no 496 0.173636326552228 956 723597 SGTC_2283 7944793 200 µM 0.937727119518504 0.144477922343159 no 497 0.174192331594506 865 2970533 SGTC_2840 9008771 71.43 µM 0.936988018159451 0.144665378242603 no 498 0.174382360639086 826 2992978 SGTC_1365 1672-3266 55.4 µM 0.936319184495692 0.144835153517563 no 499 0.174554436748432 876 6415873 SGTC_2746 daunorubicin 9.88 µM 0.936301253511723 0.144839706925212 no 500 0.174559051477772 756 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1183 1254-0324 198 µM 0.934138484763604 0.145389629107883 no 501 0.175116231199578 870 5799357 SGTC_618 k072-0232 33.2 µM 0.925911295183933 0.147494357534079 no 502 0.177246040423414 852 5872756 YGL099W LSG1 SGTC_3292 9120825 59.784 µM 0.921049900297799 0.148747576645494 no 503 0.178512187542778 912 24824900 SGTC_2960 9079389 5.97 µM 0.920551708433973 0.148876406403617 no 504 0.178642262343625 893 16457355 SGTC_3086 9117350 49.47 µM 0.920500294660106 0.148889705974255 no 505 0.178655689557285 848 2679265 SGTC_2356 9061756 188.97 µM 0.920379672074026 0.148920911402105 no 506 0.178687193828567 896 20104043 SGTC_1204 4049-0315 18.3 µM 0.918350275156286 0.149446577746871 no 507 0.179217757199446 865 588402 SGTC_1064 honokiol 6.76 µM 0.916983798501246 0.149801227492512 no 508 0.179575565003026 890 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1832 st054113 55 µM 0.914484100867734 0.150451440420359 no 509 0.18023126420382 874 1251267 SGTC_306 1672-3436 11.6 µM 0.913962114857095 0.150587454611342 no 510 0.180368376505103 907 6797378 SGTC_143 4032-1194 15.74 µM 0.912019571628107 0.151094343493599 no 511 0.180879207415999 959 1806963 SGTC_3048 9093155 49.47 µM 0.910563853135027 0.151474943233236 no 512 0.181262611708602 851 25236002 SGTC_2938 9059746 27.26 µM 0.907736291281972 0.152216033512879 no 513 0.182008782536191 857 6471769 SGTC_903 1134-0042 114 µM 0.906427376724258 0.152559907440378 no 514 0.182354843936962 889 701009 SGTC_2791 5663188 71.43 µM 0.905410086807583 0.152827522360712 no 515 0.18262408698896 875 54690634 SGTC_3055 9094636 49.47 µM 0.904624305316194 0.153034448143212 no 516 0.18283222724338 872 25236176 SGTC_1629 st005085 44.9 µM 0.902629968506404 0.153560465448352 no 517 0.183361157870182 886 24207091 SGTC_822 1487-0950 154 µM 0.901874678819516 0.153759989479415 no 518 0.18356172183081 915 1958375 SGTC_1332 1480-0653 17.5 µM 0.900740465827017 0.154059935469038 no 519 0.183863163966854 917 5749438 SGTC_1022 4477-0945 21.3 µM 0.900659330225154 0.154081406845644 no 520 0.183884739353668 909 4648966 SGTC_2289 7946404 165.07 µM 0.900460754904006 0.154133965315658 no 521 0.183937550683674 945 1246120 YPR165W RHO1 SGTC_68 0986-0284 82.829 µM 0.899269766582991 0.154449442267844 no 522 0.184254493534107 747 423278 YIL048W NEO1 SGTC_452 diindolylmethane 8 µM 0.898429916105342 0.154672163940654 no 523 0.184478196654119 842 3071 Inhibits expression of several cancer promoting factors. SGTC_1276 0871-0068 94.2 µM 0.893129140001904 0.156082782425562 no 524 0.185894009759005 902 3414906 SGTC_1455 4262-0120 131 µM 0.893097453795991 0.156091240025039 no 525 0.185902493209184 946 1529587 SGTC_2374 9071832 200 µM 0.891223224484496 0.156592041659169 no 526 0.186404713686744 912 17381698 SGTC_3149 9097855 49.47 µM 0.889261882293593 0.157117251643523 no 527 0.186931176048169 896 25236625 YMR079W SEC14 SGTC_2669 eugenol 100 µM 0.888951797061525 0.157200392481723 no 528 0.187014493095796 884 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3194 9111903 49.47 µM 0.888947350224055 0.157201584989422 no 529 0.187015688087159 891 17087251 SGTC_1529 apigenin 74 µM 0.888502925305234 0.157320796353753 no 530 0.187135141495736 936 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_998 3996-0085 177 µM 0.888104447520191 0.157427733498602 no 531 0.187242285257009 984 715391 SGTC_1562 morin hydrate 59.1 µM 0.885965371042066 0.158002601317278 no 532 0.187818093920231 897 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1802 st050112 57.9 µM 0.885536777584198 0.15811794953196 no 533 0.187933596492598 960 4662563 SGTC_3218 9131285 49.47 µM 0.883880901748247 0.158564117867525 no 534 0.188380253924994 987 17156417 SGTC_1684 st024538 14.6195 µM 0.883745976776524 0.15860050914027 no 535 0.188416677536346 930 6732859 SGTC_790 1575-0012 79.1 µM 0.88345409704193 0.158679252185784 no 536 0.188495486662397 975 378741 YLR208W SEC13 SGTC_1751 st044839 27.194 µM 0.882714123530731 0.158878996402173 no 537 0.188695374636221 935 5291326 SGTC_3058 9093861 49.47 µM 0.882478658954078 0.158942590909446 no 538 0.188759007734992 918 17217477 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.882064310026981 0.159054539178131 no 539 0.188871015524378 972 3256 An antibiotic and ribosome inhibitor. SGTC_683 panaxydol 45 µM 0.880698165519747 0.159424008231283 no 540 0.189240604987108 957 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_607 4491-0986 66.8 µM 0.880221741256304 0.159552987560379 no 541 0.18936959891942 972 698981 YDR232W HEM1 SGTC_3277 9138724 49.47 µM 0.880174563427398 0.159565763431223 no 542 0.189382375465195 830 15943418 SGTC_178 4092-0806 87.505 µM 0.878763197817304 0.159948274292653 no 543 0.189764842216371 947 2169044 SGTC_355 1311-2252 105 µM 0.878582528860803 0.15999728278195 no 544 0.189813836069954 893 5338538 SGTC_3101 9120531 49.47 µM 0.877568185021678 0.160272617287444 no 545 0.190089050491692 948 24824904 SGTC_1403 3909-7815 62.9 µM 0.875980758200625 0.160704131195251 no 546 0.190520247179491 906 6615483 SGTC_90 0870-0863 4.608 µM 0.875644056114371 0.160795755141479 no 547 0.190611783542361 959 1738164 SGTC_1130 3454-2858 15.9 µM 0.875377982592825 0.160868183643571 no 548 0.190684137804474 878 715628 YIL048W NEO1 SGTC_2312 7706453 155.7 µM 0.874252934638612 0.161174670989567 no 549 0.190990262141875 917 976098 SGTC_2184 6075246 200 µM 0.874131234196364 0.161207847636358 no 550 0.191023394758718 916 2267320 SGTC_232 clozapine 119 µM 0.873006892293259 0.161514564156309 no 551 0.191329660502452 931 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_705 1124-0212 310 µM 0.872180262541059 0.161740308386833 no 552 0.191555022633388 948 9554485 SGTC_872 0588-0139 234 µM 0.8706006385803 0.162172259336393 no 553 0.191986123840268 994 2047100 SGTC_1306 1185-0270 9.02 µM 0.869203544358611 0.162554922599536 no 554 0.192367904565224 982 1548076 SGTC_2116 5511452 16.8835 µM 0.867422482027042 0.16304360567214 no 555 0.192855284011704 942 870744 SGTC_1441 4106-0040 13 µM 0.865696768232912 0.163518012306378 no 556 0.193328236379701 974 2904180 SGTC_1004 4084-0029 199 µM 0.865621287703577 0.163538782691416 no 557 0.193348938858126 1003 716894 YLR208W SEC13 SGTC_589 1227-0070 34.1 µM 0.865036027652553 0.163699890002275 no 558 0.193509507399494 938 2841384 SGTC_3314 9135860 59.4275 µM 0.864021868730852 0.163979306209846 no 559 0.193787938658822 993 25252478 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.861204388496367 0.164757187811128 no 560 0.194562741739755 917 5282362 SGTC_1270 0831-1170 17.3 µM 0.860038372945164 0.16507981270064 no 561 0.194883945142437 998 6764716 SGTC_1851 st056236 18.9 µM 0.859156740954641 0.165324022837006 no 562 0.19512702309954 1004 5393171 SGTC_1336 1486-0901 104 µM 0.85898175930557 0.165372520160534 no 563 0.195175289833437 943 5006114 SGTC_2737 bleomycin 30.5 nM 0.85889643424117 0.16539617190573 no 564 0.195198828431165 1003 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3118 9124250 49.47 µM 0.857343171724731 0.165827112188914 no 565 0.195627627950711 868 1504786 SGTC_3204 9114183 49.47 µM 0.857078346315391 0.165900658243028 no 566 0.195700793677606 902 17027248 SGTC_1177 0983-0204 23.6 µM 0.856590152858422 0.166036292254735 no 567 0.195835714857331 1008 766818 SGTC_1924 st058459 75.1 µM 0.854974514164312 0.166485673355088 no 568 0.196282628494369 953 688683 SGTC_2340 7987427 183.45 µM 0.854831963118945 0.166525360812089 no 569 0.196322090244101 905 2239331 SGTC_2955 9076254 12.21 µM 0.854363857491242 0.166655728460659 no 570 0.196451707593121 920 16459619 SGTC_1866 st057638 64 µM 0.853792766962833 0.166814866624274 no 571 0.196609911432174 954 688802 SGTC_2788 5282734 71.43 µM 0.85072240223909 0.167672123822741 no 572 0.197461787878356 1004 743706 SGTC_1383 3049-0032 20.7 µM 0.849350598760679 0.168056051802874 no 573 0.197843116672475 1013 712864 SGTC_163 TUB2.036 7.546 µM 0.843700449331966 0.169643322653834 no 574 0.199418408198075 1066 15992207 YJR013W GPI14 SGTC_2941 9056145 11.23 µM 0.841738869686989 0.170196621883032 no 575 0.199967067997915 908 2119517 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.841096546481644 0.17037805185591 no 576 0.200146924836664 1039 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_492 tmb-8 126 µM 0.840253889757665 0.170616255618821 no 577 0.200383024428283 850 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2295 7971645 200 µM 0.838671510023718 0.171064141445897 no 578 0.20082683497614 952 2978226 YKL099C UTP11 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.836832811527075 0.171585520921693 no 579 0.201343275611147 1048 368090 SGTC_1849 st056239 19.2 µM 0.834688876129048 0.172194733788235 no 580 0.201946453225929 954 5393181 SGTC_2237 6667747 47.222 µM 0.834003612499751 0.172389746548428 no 581 0.202139474084326 927 729940 YDL015C TSC13 SGTC_276 colchicine 750 µM 0.833818840129848 0.172442353292429 no 582 0.20219153852183 1012 2833 A microtubule depolymerizer. SGTC_572 0960-0087 17.7 µM 0.833409467199816 0.172558942777301 no 583 0.202306918603427 1058 6796365 SGTC_2847 9005661 71.43 µM 0.832347482028731 0.172861630618888 no 584 0.202606418302914 902 2991449 SGTC_715 0868-0130 184 µM 0.832212399336368 0.172900156235379 no 585 0.202644533140476 998 2876258 SGTC_1988 st071872 53.4 µM 0.829514656805198 0.173670698566621 no 586 0.20340662330471 1020 16414116 SGTC_2002 4023503 131 µM 0.828934749835559 0.173836619273955 no 587 0.203570665281584 1092 4736863 YCR052W RSC6 SGTC_3219 9131112 49.47 µM 0.828656698558965 0.173916209960846 no 588 0.203649347393454 959 17612988 YMR079W SEC14 SGTC_2757 clomiphene 4.22 µM 0.828038690184491 0.174093194517986 no 589 0.203824294471795 1078 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2627 acetyl isogambogic acid 100 µM 0.827209757981296 0.174330762907396 no 590 0.204059090905689 975 6857789 A caspase activator and apoptosis inducer. SGTC_211 3455-0679 143.504 µM 0.827113216561991 0.174358444646299 no 591 0.204086446896177 1022 748649 SGTC_1989 st071868 50.2 µM 0.826917434041707 0.174414590789009 no 592 0.204141930566272 1044 16414057 SGTC_890 0929-0006 47.2 µM 0.826391851194953 0.174565373242207 no 593 0.204290922228348 968 1378169 SGTC_631 k072-0230 41.5 µM 0.823914499462684 0.175277205419205 no 594 0.204994070598592 1037 5773147 SGTC_2491 paeonol 100 µM 0.822324126968962 0.175735145275348 no 595 0.205446224346157 988 11092 Increases levels of cortical cytochrome oxidase. SGTC_2231 micatex 6.853 µM 0.820620527991609 0.176226528157889 no 596 0.205931225549875 1025 20737 An antifungal of unknown mechanism. SGTC_2736 butenafine 14.65 µM 0.818106340295363 0.176953302630936 no 597 0.206648234417639 1019 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2863 9028737 58.44 µM 0.817097770719822 0.177245380666121 no 598 0.206936278414776 1013 6460917 SGTC_987 1497-1013 404 µM 0.816757861787581 0.1773438855989 no 599 0.207033408743531 1039 1676435 SGTC_1142 3253-1408 9.78 µM 0.8159611883798 0.177574895386817 no 600 0.2072611670116 1010 256655 SGTC_3231 9132313 49.47 µM 0.812599461839367 0.178551778594043 no 601 0.208223870111228 1016 4905967 SGTC_1317 1273-0028 910 nM 0.811765705622688 0.17879458243257 no 602 0.208463041938402 1029 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_262 fenpropimorph 62.5 µM 0.809783000834296 0.179372813777663 no 603 0.209032452162713 951 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_840 0245-0196 390 µM 0.809408503678169 0.179482163114177 no 604 0.209140106232937 1063 3827528 SGTC_846 0335-0850 148 µM 0.803938143863113 0.18108422604523 no 605 0.210716349756677 1022 6819598 SGTC_2024 5144227 134 µM 0.803878577523088 0.181101719950925 no 606 0.210733551621371 1047 3475211 SGTC_2670 beta-carotene 100 µM 0.800876265383004 0.181984833505782 no 607 0.211601640890468 990 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1539 benzyladenosine 56 µM 0.799164049157194 0.182489676123997 no 608 0.2120976474471 1052 92208 A nucleotide analog. SGTC_2255 7941087 197.44 µM 0.798610939092641 0.182652945985972 no 609 0.212258021330665 1092 935561 SGTC_2022 5136654 200 µM 0.797854112752654 0.182876497599411 no 610 0.212477577412276 1013 1713771 SGTC_1296 1068-0102 11.9 µM 0.795781591307252 0.183489553282533 no 611 0.213079496657013 1016 767053 SGTC_2687 chenodiol 100 µM 0.792549196910468 0.184448255042364 no 612 0.214020258868827 1000 5702181 A cholesterol synthesis inhibitor. SGTC_2105 5350118 200 µM 0.792190612123471 0.184554800026757 no 613 0.214124770834507 1062 2133313 SGTC_3144 9087057 49.47 µM 0.791579393518717 0.184736497374203 no 614 0.214302983076236 1002 17249618 SGTC_3117 9124945 49.47 µM 0.791108019931172 0.184876698827402 no 615 0.214440479786486 961 17592065 SGTC_3111 9122088 49.47 µM 0.790882367139262 0.184943838522385 no 616 0.214506319438224 962 16876704 SGTC_2948 9070189 9.45 µM 0.789157732340202 0.185457478716421 no 617 0.215009911317694 967 6473636 YDL196W YDL196W SGTC_517 1365-0151 113 µM 0.787737130427107 0.185881234557502 no 618 0.21542524103412 1021 768657 SGTC_2678 equilin 100 µM 0.787513216030699 0.185948081430286 no 619 0.21549074748203 1087 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2044 5102272 200 µM 0.786577621415431 0.186227552856196 no 620 0.215764581866298 1001 592666 SGTC_1571 st070080 73.4 µM 0.785864288736421 0.186440807214351 no 621 0.215973498996196 1059 4315245 SGTC_699 0375-0592 111 µM 0.783183051975048 0.187243728279638 no 622 0.216759812916286 1113 762578 SGTC_1807 st050092 58.9 µM 0.780471607219353 0.188057866222494 no 623 0.217556666739382 1046 5008496 SGTC_266 formosanin C 406 nM 0.779976146032541 0.188206869082624 no 624 0.217702457993647 1064 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3090 9117696 49.47 µM 0.778349448311127 0.18869658715401 no 625 0.218181515857873 1059 7923821 SGTC_2243 6634756 200 µM 0.777964926158939 0.188812462396355 no 626 0.218294845250863 1037 885676 SGTC_1067 clotrimazole 1.36 µM 0.777943689799652 0.188818863222667 no 627 0.218301105185774 1089 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1876 myriocin 605 nM 0.77776174996221 0.188873706977262 no 628 0.218354740629241 1084 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3344 9148862 3.898 µM 0.774353025435313 0.189903043229671 no 629 0.21936102722951 1090 4905352 SGTC_2451 5856223 45.7 µM 0.771215897603889 0.190853406457372 no 630 0.220289486344638 1059 2179896 SGTC_477 mead ethanolamide 10 µM 0.769700910679121 0.191313400420805 no 631 0.220738664880668 949 16061185 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.768850733777598 0.191571836191047 no 632 0.220990963467991 1127 4174840 SGTC_2201 6605497 169.863 µM 0.768320533288188 0.191733114126035 no 633 0.22114838934745 1083 670741 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.765897040742127 0.192471357192187 no 634 0.221868783430693 1128 6728940 SGTC_3261 9137475 49.47 µM 0.765246701805317 0.192669758462611 no 635 0.222062327451187 947 17027690 SGTC_195 4234-0266 16.654 µM 0.763343184790628 0.193251189214527 no 636 0.222629376915321 1098 2303354 SGTC_2272 7805186 180 µM 0.762428342674555 0.19353100905873 no 637 0.222902197834875 1083 2956062 YPR165W RHO1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.761421900734775 0.19383913157294 no 638 0.223202555223697 1044 1241132 A phosphatase inhibitor. SGTC_21 0849-0113 22.993 µM 0.760758241248571 0.194042474634161 no 639 0.223400740356292 1096 1560156 SGTC_2413 inermin 26.06 µM 0.760304287313241 0.194181639434953 no 640 0.223536359872511 1102 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2415 st077333 57.7 µM 0.759475288786079 0.194435935291184 no 641 0.223784145406121 1145 2766255 SGTC_1817 st052116 64.4 µM 0.758700347468352 0.194673832293254 no 642 0.224015914503421 1084 4361398 SGTC_3047 9092122 49.47 µM 0.75745830496284 0.195055492527564 no 643 0.22438766829791 1083 17173831 SGTC_1408 3909-7976 48.8 µM 0.756802452885917 0.195257208992268 no 644 0.224584111535985 1145 24152374 SGTC_1175 0741-0056 27.6 µM 0.756567545602553 0.195329488827107 no 645 0.224654495557423 1171 765927 SGTC_1617 st002906 78 µM 0.756375838955415 0.195388488079626 no 646 0.224711944872358 1101 5150859 SGTC_1164 k060-0068 93.7 µM 0.754848684405585 0.19585886858932 no 647 0.225169889369556 1153 5963676 SGTC_1145 3546-0597 10.2 µM 0.75371759622805 0.196207698826572 no 648 0.225509406822421 1073 875334 SGTC_3100 9120536 49.47 µM 0.7536323418441 0.196234006736295 no 649 0.225535009271822 1008 16421196 SGTC_1963 st076565 50.3 µM 0.751771138840747 0.196808872072068 no 650 0.226094350539105 1127 4914280 SGTC_2729 fluphenazine 10.66 µM 0.751262243509382 0.196966230718488 no 651 0.226247423572985 1094 3372 An atypical antipsychotic. SGTC_2771 fluoxetine 41.05 µM 0.751230929153251 0.196975916109385 no 652 0.226256844678168 1078 3386 A selective serotonin reuptake inhibitor. SGTC_2505 galangin 7.89 µM 0.750926172944992 0.197070190902119 no 653 0.226348543919878 1016 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1521 st012942 49.4 µM 0.749987572206599 0.197360713810859 no 654 0.226631094868102 1143 24207259 SGTC_2208 7283366 200 µM 0.749960217697882 0.197369184671255 no 655 0.226639332495893 1124 898663 SGTC_1702 st027038 51 µM 0.748453506891984 0.197836106786387 no 656 0.227093329338644 1129 5521182 SGTC_2973 9094665 17.96 µM 0.747852799845521 0.198022448805654 no 657 0.22727447514409 1137 25237061 YIL048W NEO1 SGTC_1650 st011916 45.8 µM 0.747852414996366 0.198022568221552 no 658 0.227274591223109 1112 242528 SGTC_2246 7293507 91.5585 µM 0.747315256861342 0.198189286880547 no 659 0.227436642562591 1136 887656 SGTC_1987 st072290 61.9 µM 0.747291162065976 0.198196767207204 no 660 0.227443913071429 1112 54697379 SGTC_3271 9137798 49.47 µM 0.747056431154282 0.198269649285558 no 661 0.227514749041679 1046 6498326 SGTC_775 4577-0580 57.3 µM 0.746937415078566 0.198306609008494 no 662 0.227550669889242 1142 2006902 SGTC_569 4130-2812 160 µM 0.746061269067545 0.198578818810768 no 663 0.227815202245859 1027 743552 SGTC_762 1165-0429 115 µM 0.745705490011421 0.198689420114662 no 664 0.227922671023607 1122 5967793 SGTC_3162 9099653 49.47 µM 0.745464991675704 0.198764205051371 no 665 0.22799533356186 1099 25237511 SGTC_426 0988-0037 14.6 µM 0.744095749762136 0.199190305360052 no 666 0.228409275223347 1147 5383008 SGTC_1449 4112-4002 201 µM 0.741725168311695 0.199929316459131 no 667 0.229126933794696 1110 2059539 SGTC_3284 9108171 64.8615 µM 0.739890583638623 0.200502364666004 no 668 0.229683194260169 1055 8687505 SGTC_991 3996-0057 64.7 µM 0.736642171074103 0.201519450510207 no 669 0.230669991274559 1084 715343 SGTC_2377 9073351 62.6 µM 0.735528902103872 0.201868727754916 no 670 0.231008722337884 1109 7337946 YHR072W ERG7 SGTC_1248 0469-0687 58.6 µM 0.734940560826525 0.202053460367092 no 671 0.231187847284509 1129 4017482 SGTC_1127 asiatic acid 681.4 nM 0.73406951663358 0.20232714424141 no 672 0.231453185511387 1103 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1063 disulfiram 1.84 µM 0.733977782136507 0.202355980307731 no 673 0.231481139631843 1147 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_909 3448-9333 149 µM 0.731794332470061 0.203043056912717 no 674 0.232147054415067 1085 3344074 SGTC_2186 6124449 200 µM 0.731499291703598 0.203136005523955 no 675 0.232237118500246 1108 3834182 YLR033W RSC58 SGTC_3014 9081533 49.47 µM 0.730509580027902 0.203447986299307 no 676 0.232539379647343 1140 21367265 SGTC_2393 9031399 185.94 µM 0.729287432047384 0.203833630716179 no 677 0.232912929232002 1162 1526623 YDL150W RPC53 SGTC_3309 9129340 25.759 µM 0.729004431639472 0.203922992569166 no 678 0.232999475824394 1160 17158987 SGTC_157 1348-1695 65.819 µM 0.728856322603862 0.203969769643603 no 679 0.233044777338171 1153 5380510 SGTC_3269 9137823 49.47 µM 0.728384555595762 0.204118809784078 no 680 0.233189107407844 1080 17682936 SGTC_1973 st070275 50.2 µM 0.728312221514149 0.204141667225695 no 681 0.23321124132597 1111 17118334 SGTC_2976 9009005 19.48 µM 0.727237261505207 0.204481532326571 no 682 0.233540311869513 1161 2993148 SGTC_1442 4112-3290 3 µM 0.72678250246027 0.204625412682703 no 683 0.233679601785228 1164 704353 SGTC_522 1273-0010 11.6 µM 0.726461726825733 0.204726938498975 no 684 0.233777881096218 1198 5705015 SGTC_2460 5552655 174.22 µM 0.726341117354002 0.204765119269542 no 685 0.233814839378591 1158 5401989 SGTC_1913 st060213 96.1 µM 0.726338475281916 0.204765955705219 no 686 0.233815649023272 1171 688959 SGTC_2708 st078559 56 µM 0.725214126856809 0.205122089956231 no 687 0.23416033879201 1075 17250902 SGTC_988 1497-1057 103 µM 0.724745845379374 0.205270525332351 no 688 0.234303982076462 1143 3533044 SGTC_422 cantharidin 155 µM 0.724117093327592 0.205469926833057 no 689 0.234496925685826 1160 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3240 9133527 49.47 µM 0.724012259126701 0.205503184981469 no 690 0.234529104448862 1124 17617455 SGTC_1200 1643-0193 18.4 µM 0.722178703493321 0.206085388408679 no 691 0.235092307483022 1173 5403974 SGTC_3127 9126946 49.47 µM 0.722080752353772 0.206116518036049 no 692 0.23512241559309 1058 27243249 SGTC_2980 9014342 25.29 µM 0.721450934438521 0.206316745614036 no 693 0.235316059171911 1147 2996599 SGTC_3073 9114972 49.47 µM 0.721073000672348 0.206436951157315 no 694 0.23543230079815 1067 41905075 SGTC_3021 9087658 49.47 µM 0.720453794601186 0.206633985386263 no 695 0.235622819364031 1157 25237042 SGTC_3128 9127691 49.47 µM 0.720231142161811 0.206704861634353 no 696 0.235691346294787 1065 41316314 SGTC_2531 methyl deoxycholate 70.07 µM 0.720208535788308 0.206712058654744 no 697 0.235698304593721 1139 16667744 Haematoxylin. SGTC_672 1441-0018 53.7 µM 0.719722976161674 0.206866678421846 no 698 0.235847788421601 1135 251141 SGTC_2603 homopterocarpin 100 µM 0.718616802780714 0.207219179596366 no 699 0.23618852875821 1165 101795 A weak amylase inhibitor. SGTC_2879 9041815 71.43 µM 0.718085970495301 0.207388464498971 no 700 0.236352140014977 1114 4942971 SGTC_204 PMA1.184 62.41 µM 0.717893499090366 0.207449864722341 no 701 0.236411478283369 1199 2252213 YGL008C PMA1 SGTC_1559 coumarin 343 70.1 µM 0.717289603008089 0.20764258309715 no 702 0.236597710575378 1163 108770 A hepatotoxic, DNA x-linker. SGTC_1135 dihydrocapsaicin 536.708 nM 0.715976090203505 0.208062123029316 no 703 0.23700305635145 1123 107982 A Capsaicinoid. SGTC_992 3909-8734 162 µM 0.71553306042734 0.208203740833077 no 704 0.237139859926653 1179 4288319 SGTC_2248 tofa 1.1 µM 0.715149076105 0.208326530313123 no 705 0.237258465889984 1105 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1192 1488-0095 21.4 µM 0.714879267734421 0.20841283446042 no 706 0.237341824408082 1144 915875 SGTC_341 1486-1430 230 µM 0.713233881313733 0.208939603761324 no 707 0.237850521918345 1152 2054753 YPL210C SRP72 SGTC_1364 1653-0028 37.6 µM 0.713008978307894 0.209011667178017 no 708 0.237920100696065 1137 5718652 SGTC_1398 3558-0053 112 µM 0.711083239757254 0.209629311335634 no 709 0.238516327653555 1100 4532369 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.709329415668025 0.210192750031007 no 710 0.239060039148507 1178 5355888 SGTC_1249 0481-0015 10.2 µM 0.705797994198335 0.211329959761797 no 711 0.240156884811772 1161 4227577 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.705357101538934 0.211472191320602 no 712 0.240294016688654 1199 115019 SGTC_3080 9117754 49.47 µM 0.704792612037163 0.21165437690954 no 713 0.240469653443491 1228 9550191 SGTC_656 4090-1979 187 µM 0.704594172549558 0.211718443877774 no 714 0.240531413034456 1199 22330961 SGTC_717 1532-0246 73.2 µM 0.704240948773904 0.211832511638304 no 715 0.240641366935413 1168 9561992 SGTC_3217 9129673 49.47 µM 0.703847427526853 0.211959635133482 no 716 0.240763897121363 1180 17248312 SGTC_2493 resveratrol 26.09 µM 0.702295789315229 0.212461312528152 no 717 0.241247359323 1114 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_474 dl-dihydrosphingosine 5 µM 0.702291711455583 0.212462631899561 no 718 0.241248630604523 1229 3058739 A sphingolipid protein kinase C inhibitor. SGTC_189 3970-0742 2.116 µM 0.702143647484115 0.212510540510495 no 719 0.2412947923323 1203 2891807 SGTC_986 1493-0483 84 µM 0.701981561584213 0.212562993388936 no 720 0.241345331162563 1137 40079 SGTC_192 3455-0609 60.9 µM 0.701933910150241 0.212578415384239 no 721 0.241360190104858 1229 3769639 SGTC_1491 4138-0063 26.5 µM 0.69974110138372 0.213288806627391 no 722 0.242044501659358 1162 23883227 SGTC_311 1315-0136 58 µM 0.698275064039728 0.213764521137808 no 723 0.242502595303618 1208 6759207 SGTC_133 0724-0033 378.92 µM 0.697618381315053 0.213977808374819 no 724 0.242707941564211 1106 280309 SGTC_2156 5649887 115 µM 0.6956982226494 0.214602176478539 no 725 0.243308919422758 1247 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2699 st077704 54.6 µM 0.694553590228047 0.214974873943946 no 726 0.243667552666366 1194 645852 SGTC_96 0929-0093 37.281 µM 0.693555140865006 0.215300280279221 no 727 0.243980617139142 1168 6991579 SGTC_2086 5274770 176.623 µM 0.693372804116626 0.215359736810232 no 728 0.244037812372887 1203 689278 SGTC_190 3970-0790 3.722 µM 0.693352986396665 0.215366199564121 no 729 0.244044029213885 1174 2832352 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.691447343601473 0.215988173921333 no 730 0.244642230352576 1281 688801 SGTC_2866 9034245 58.44 µM 0.691378027892543 0.216010817167252 no 731 0.244664004149617 1198 6462273 SGTC_63 0099-0242 26.702 µM 0.691225331479953 0.216060703098327 no 732 0.244711973591412 1215 3898502 YLR359W ADE13 SGTC_1625 st003711 30.1 µM 0.691045985734916 0.216119303889516 no 733 0.244768321363131 1239 24207034 YER133W GLC7 SGTC_2628 lathosterol 100 µM 0.690730514231053 0.216222405778739 no 734 0.244867454774743 1265 6710616 SGTC_648 0375-0473 33.3 µM 0.689640218792469 0.21657895360121 no 735 0.245210234316067 1201 1713139 SGTC_1245 0418-0076 17.2 µM 0.689035344448648 0.216776905884603 no 736 0.245400512839298 1203 6790114 SGTC_3177 9107506 49.47 µM 0.68885215183587 0.216836878468167 no 737 0.245458156360002 1151 8897194 SGTC_1743 st037606 46.3785 µM 0.68779012003811 0.217184749513172 no 738 0.245792479360064 1222 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3300 9124615 50.48 µM 0.685108095891243 0.21806468661502 no 739 0.246637855941429 1235 24824903 SGTC_2074 5212007 75.395 µM 0.684534483870729 0.218253147644449 no 740 0.2468188609324 1157 758611 SGTC_581 0958-0271 211 µM 0.684288142771568 0.218334112153105 no 741 0.246896616425551 1229 4591145 SGTC_732 3970-1727 52.7 µM 0.683869115074986 0.218471873010665 no 742 0.247028909099757 1215 1275699 SGTC_78 0336-0123 156.75 µM 0.681995716879106 0.219088389103813 no 743 0.247620829593126 1097 6765896 SGTC_363 0455-0021 3.06 µM 0.68168900474175 0.219189420130948 no 744 0.24771781074088 1232 4597466 SGTC_1060 3448-7350 82 µM 0.681628938193501 0.21920920919734 no 745 0.247736805917316 1178 570178 SGTC_13 0199-0087 65 µM 0.681083440332827 0.219388971767403 no 746 0.247909347318635 1241 4589825 SGTC_3270 9137563 49.47 µM 0.680379117991024 0.219621198365573 no 747 0.248132219859346 1185 17015724 SGTC_1094 duloxetine 25.4 µM 0.68026190617323 0.219659858715795 no 748 0.248169320200808 1224 60834 A selective serotonin reuptake inhibitor. SGTC_2027 5150920 200 µM 0.678454095212271 0.220256629550857 no 749 0.248741910084628 1212 786715 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.676252426907839 0.220984669353692 no 750 0.249440195769391 1278 65057 A dermal irritant. YDR527W RBA50 SGTC_2514 salinomycin 42.74 µM 0.675567168319702 0.221211548970417 no 751 0.249657746201817 1273 23682228 A polyether potassium ionophore. SGTC_1382 3002-2117 298 µM 0.674970076423761 0.221409346407719 no 752 0.249847388305997 1263 1497314 SGTC_357 1325-0123 420 µM 0.672032934460721 0.222383798491481 no 753 0.250781364918322 1218 1098503 SGTC_1732 st034308 51.822 µM 0.67130627850892 0.222625257203017 no 754 0.251012717886795 1158 830119 SGTC_973 1325-0077 65.9 µM 0.671051343599813 0.222710004295735 no 755 0.251093910901792 1265 2835149 SGTC_104 0074-0074 590.992 µM 0.670713753963679 0.222822256291805 no 756 0.25120144960694 1106 3943124 SGTC_2297 7971671 152.32 µM 0.669651174054589 0.223175785294384 no 757 0.251540091870303 1252 909016 SGTC_1325 1431-0015 227 µM 0.667897967934229 0.223759788779563 no 758 0.252099362306641 1190 1103340 SGTC_2808 7946468 45.46 µM 0.66742818546474 0.223916423595119 no 759 0.252249333649223 1240 2970879 SGTC_2103 5378138 10 µM 0.667412318792455 0.223921714946624 no 760 0.252254399678836 1279 244142 SGTC_545 4218-0007 221 µM 0.666686775087249 0.224163751270984 no 761 0.25248611399513 1210 2840508 SGTC_2825 7998094 58.44 µM 0.665767994399484 0.2244704631959 no 762 0.252779702585475 1220 2987815 SGTC_1018 4259-0013 28.1 µM 0.6650708523884 0.224703345414128 no 763 0.253002588286182 1243 6801262 SGTC_3151 9099821 49.47 µM 0.664930616379301 0.224750208190091 no 764 0.253047436118725 1203 17174189 SGTC_1525 8-methoxypsoralen 92.5 µM 0.66480510975727 0.224792153534624 no 765 0.253087577002126 1284 4114 Related to psoralen; DNA damaging agent. SGTC_2088 5278280 127.392 µM 0.664383398667654 0.224933125356384 no 766 0.253222477730033 1277 791502 SGTC_629 3448-6466 76.7 µM 0.662144861787375 0.225682273785859 no 767 0.253939193574023 1245 573744 SGTC_406 estrone 100 µM 0.660233954495891 0.226322893044151 no 768 0.254551852937849 1279 5870 A steroid. SGTC_1769 st044406 64.4 µM 0.659936345164749 0.226422757001977 no 769 0.254647339632935 1255 670903 SGTC_2025 5147754 141 µM 0.659754685007531 0.226483725995964 no 770 0.2547056337446 1252 315777 YLR208W SEC13 SGTC_196 k015-0023 18.111 µM 0.659704282460871 0.226500643800104 no 771 0.25472180898453 1244 5211998 SGTC_1088 bifonazole 369 nM 0.659189145194695 0.226673592465163 no 772 0.254887158230262 1204 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2829 7992743 58.44 µM 0.659156004155467 0.226684721562203 no 773 0.254897797795217 1235 16462845 SGTC_3004 9076122 71.4286 µM 0.658579238854527 0.226878454573699 no 774 0.255082999145644 1242 44782551 SGTC_2644 guaiazulene 100 µM 0.658561083655161 0.226884554343753 no 775 0.255088829985947 1257 3515 A coloring agent. SGTC_2329 6138490 200 µM 0.657553711088705 0.227223155544973 no 776 0.255412473444925 1265 720019 SGTC_1922 5578187 25 µM 0.656990376685132 0.227412629348986 no 777 0.255593552120504 1305 1350412 SGTC_1686 st019653 115.5 µM 0.656081747336645 0.227718428294697 no 778 0.255885763925952 1277 97252 SGTC_2557 derrustone 83.84 µM 0.654942035387797 0.22810232505689 no 779 0.256252537373784 1249 629853 An antioxidant. SGTC_643 k048-0106 28.4 µM 0.654788600611971 0.228154035295258 no 780 0.256301935512092 1279 6763920 SGTC_1620 st003704 16.5 µM 0.652604248139994 0.228890915242578 no 781 0.257005723077847 1249 2834414 SGTC_2403 6032726 181.2 µM 0.651991736973562 0.22909778222242 no 782 0.257203251462826 1261 2881040 SGTC_253 dyclonine 31.25 µM 0.648721375136242 0.230204073695092 no 783 0.258259242837204 1336 3180 An oral anasthetic. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.646188804917868 0.231062835496202 no 784 0.259078544402287 1236 688662 SGTC_2290 7904846 200 µM 0.64612333877968 0.231085057898388 no 785 0.259099740893663 1296 2962154 SGTC_653 0203-0016 55.2 µM 0.645542607530534 0.231282238637102 no 786 0.259287808109094 1305 295302 SGTC_1008 4106-0037 6 µM 0.645358802771326 0.231344667015657 no 787 0.259347347150924 1250 2905394 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.644951509649285 0.231483035593281 no 788 0.259479304928262 1314 688751 SGTC_2448 5185112 27.17 µM 0.644496668798722 0.231637611950406 no 789 0.25962670853742 1267 5718189 SGTC_1892 st058411 7.36 µM 0.644171476965462 0.231748162718794 no 790 0.259732122334525 1253 3934738 SGTC_1374 2889-5571 141 µM 0.643163439416451 0.232091037401323 no 791 0.260059026887895 1279 2853281 SGTC_2831 7999036 19.48 µM 0.642663995120171 0.232261023336935 no 792 0.260221074227071 1307 2988270 SGTC_3293 9120939 62.045 µM 0.641278518245739 0.232732933015342 no 793 0.260670871755911 1290 934087 SGTC_2545 solidagenone 89.61 µM 0.640999748553436 0.232827949596983 no 794 0.260761423164127 1146 6708572 An anti ulcer agent SGTC_292 k038-0015 474 µM 0.640698363054702 0.232930698850818 no 795 0.260859338959693 1270 46368540 SGTC_1652 st011932 78 µM 0.638474717424489 0.233689568775891 no 796 0.261582353387595 1264 1551076 SGTC_1843 st055809 45.5 µM 0.637081182880844 0.234165842052118 no 797 0.262035982394096 1285 16413835 SGTC_42 0133-0086 60.653 µM 0.63683570027239 0.234249797162191 no 798 0.262115934640824 1243 162923 Model of phenazepam hydroxylation. SGTC_2127 5253358 187.912 µM 0.635097558947156 0.234844718326532 no 799 0.262682394506715 1250 20612 SGTC_193 1273-0060 1.558 µM 0.633970955053673 0.235230771552281 no 800 0.263049888713973 1179 2847393 YHR072W ERG7 SGTC_1493 4348-0038 111 µM 0.633517003678244 0.235386426005114 no 801 0.263198040278693 1334 800424 SGTC_786 4544-0069 423 µM 0.632895229434841 0.235599717123106 no 802 0.263401031663395 1347 748821 YLR208W SEC13 SGTC_487 nimodipine 119 µM 0.632283590518504 0.23580963543579 no 803 0.263600792109474 1196 4497 L-type voltage-gated calcium channels inhibitor SGTC_923 1900-2434 73.3 µM 0.631960082555616 0.235920707079174 no 804 0.263706480619623 1267 5910570 SGTC_2526 patulin 37.61 µM 0.631845921654544 0.235959909407357 no 805 0.263743781600775 1337 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2647 atorvastatin 60.16 µM 0.630675720967547 0.236361957875336 no 806 0.26412628856516 1303 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3310 9130229 44.1445 µM 0.629726432717381 0.236688383832612 no 807 0.264436792706514 1327 7761258 SGTC_2339 9000433 200 µM 0.629532361231017 0.236755148526993 no 808 0.264500294709893 1261 2988954 SGTC_2434 5670830 169.91 µM 0.628901865910685 0.236972123714429 no 809 0.264706652209987 1287 1549830 SGTC_1267 0828-0272 9.49 µM 0.627802969623802 0.237350552949984 no 810 0.265066510255403 1364 745334 SGTC_381 3461-2219 42.7 µM 0.62775526842828 0.237366987423056 no 811 0.265082136699546 1286 2883159 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.625705156159068 0.238073901930522 no 812 0.265754175324889 1289 688664 SGTC_15 0266-0086 27.098 µM 0.623676587222558 0.23877452212144 no 813 0.266420000999011 1384 1712902 YIL048W NEO1 SGTC_2617 dihydrotanshinone i 20.83 µM 0.622692454638107 0.239114824366597 no 814 0.266743321015809 1323 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2743 auranofin 4.32 µM 0.620781215067861 0.239776466650182 no 815 0.267371792293818 1259 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2742 clothiapine 36.27 µM 0.618947661505774 0.240412152861883 no 816 0.267975419391739 1289 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1377 2944-0135 198 µM 0.618572144506964 0.240542456369577 no 817 0.26809912854773 1387 1894137 SGTC_646 4092-0839 27.3 µM 0.61688955020624 0.241126784497895 no 818 0.268653789927989 1378 877796 SGTC_1360 1598-0022 39.8 µM 0.616855056468625 0.241138771483668 no 819 0.268665166697755 1374 761525 SGTC_1792 st045773 43.6 µM 0.616682753248629 0.24119865376078 no 820 0.268721999596238 1276 2919270 SGTC_2320 7373003 200 µM 0.616186105420266 0.241371304009985 no 821 0.26888584886916 1291 5415828 SGTC_882 0843-0131 351 µM 0.614440384062042 0.24197870353283 no 822 0.269462178243855 1326 5425421 SGTC_164 4100-3994 89.624 µM 0.614377984301054 0.2420004299999 no 823 0.269482790247122 1362 4615967 SGTC_1054 3429-0080 167 µM 0.614286823770721 0.242032172347971 no 824 0.269512903980834 1343 1162877 SGTC_3012 9080433 71.4286 µM 0.611988358256595 0.242833250071835 no 825 0.270272730002458 1323 17688859 SGTC_1338 1486-1223 76 µM 0.611322022173486 0.24306575430397 no 826 0.270493207269423 1376 3444526 SGTC_936 3005-4620 401 µM 0.611138230410299 0.243129905825872 no 827 0.270554036091696 1403 777207 SGTC_534 k292-0788 63.4 µM 0.610409957482019 0.243384195545147 no 828 0.270795136827115 1377 4146317 SGTC_1435 4092-0789 56.7 µM 0.609883011293536 0.243568277950688 no 829 0.27096965354255 1379 2248285 SGTC_2565 isoliquiritigenin 100 µM 0.609152445556208 0.24382361677733 no 830 0.271211698803848 1275 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_671 0560-0003 407 µM 0.608246231415826 0.244140546827855 no 831 0.271512088205677 1279 3238678 SGTC_3225 9130819 49.47 µM 0.607505039239045 0.244399928846881 no 832 0.271757899709577 1359 4547121 SGTC_892 0929-0076 29 µM 0.607086102136523 0.244546602574781 no 833 0.271896886417545 1306 5751038 SGTC_389 tpck 16.7 µM 0.606157775729108 0.24487178704974 no 834 0.272204994228956 1315 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2436 5633522 8.09 µM 0.604752890367935 0.245364348129211 no 835 0.272671599809491 1335 5724242 SGTC_1179 1021-1431 9.29 µM 0.604553081205976 0.245434445625988 no 836 0.272737994797374 1343 2840958 SGTC_54 0159-0055 9 µM 0.604345079713482 0.245507428604864 no 837 0.272807120551912 1423 3319099 SGTC_2994 9053520 71.4286 µM 0.602804646448279 0.246048294231738 no 838 0.273319327681471 1359 4647384 SGTC_1343 1487-0095 224 µM 0.600903332557901 0.246716750008873 no 839 0.273952186717727 1342 4560101 YGL055W OLE1 SGTC_548 1436-0017 110 µM 0.599761047521556 0.247118816805862 no 840 0.274332748302294 1410 9677137 SGTC_71 0417-1750 47.813 µM 0.599603389120314 0.247174337654246 no 841 0.27438529397563 1381 6811472 SGTC_567 1080-0542 68.4 µM 0.597613640923905 0.247875618705553 no 842 0.275048880107028 1299 5950415 SGTC_2442 5158906 48.48 µM 0.593786016553234 0.249227634903011 no 843 0.276327621454651 1424 1893835 SGTC_1893 st059353 36.1 µM 0.593630681198575 0.249282586061049 no 844 0.27637957775683 1306 3112488 SGTC_692 k241-0027 77.8 µM 0.591605275255103 0.249999679274407 no 845 0.277057470274728 1432 3600480 SGTC_2445 5742597 35.57 µM 0.59003820378688 0.250555249728758 no 846 0.277582518484164 1316 1774255 SGTC_877 0771-0151 33.1 µM 0.589904686303493 0.250602615615071 no 847 0.277627276060961 1394 6166523 SGTC_1235 benzylparaben 21.5 µM 0.58850735163801 0.251098610393417 no 848 0.278095900387508 1340 7180 SGTC_1073 triclabendazole 3.09 µM 0.588421509218836 0.251129097748335 no 849 0.278124701947554 1388 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2653 dihydrofissinolide 100 µM 0.588399151081622 0.251137038671483 no 850 0.278132203713441 1370 6857746 SGTC_1384 3089-0840 101 µM 0.588256119278582 0.25118784231426 no 851 0.278180197126209 1379 1069836 SGTC_58 0957-0393 9 µM 0.587804556754111 0.251348269025847 no 852 0.278331742559084 1305 6997992 SGTC_2318 6029776 164 µM 0.583407418099837 0.252913268763741 no 853 0.279809532627357 1441 818325 SGTC_2871 9038510 12.99 µM 0.580355394867412 0.254002531770444 no 854 0.280837489229238 1454 4945164 SGTC_2335 9018011 154.17 µM 0.579741953373147 0.254221764931606 no 855 0.281044323556195 1423 6458208 SGTC_443 clozapine 122 µM 0.579105146224123 0.254449453483267 no 856 0.28125911391809 1309 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_277 nystatin 15.5 µM 0.57885456298777 0.254539078082715 no 857 0.281343655522681 1334 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3040 9091894 49.47 µM 0.576472041927945 0.255392045517969 no 858 0.282148081007017 1319 25236966 SGTC_610 4215-0184 155 µM 0.575738251840189 0.255655050598641 no 859 0.282396057978617 1412 5605015 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.575494386155705 0.255742488252979 no 860 0.282478493134261 1394 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1810 st050138 53 µM 0.574904338886101 0.255954113337106 no 861 0.282677997666772 1373 3444541 SGTC_1059 3448-6867 171 µM 0.573771234624257 0.256360766139328 no 862 0.283061308319408 1364 3934407 SGTC_1263 0774-1208 64.8 µM 0.573304690565121 0.256528299066626 no 863 0.283219205019992 1444 906585 SGTC_2639 lactacystin 53 µM 0.573111476173754 0.256597697790156 no 864 0.283284608673491 1418 3870 A proteasome inhibitor. SGTC_3246 9135460 32.98 µM 0.572594976123957 0.256783262214252 no 865 0.283459481050729 1375 41446951 SGTC_1877 wortmannin 25 µM 0.572064128152175 0.256974054220688 no 866 0.283639265130771 1370 312145 A covalent inhibitor of PI 3-kinase. SGTC_2944 9067346 25.62 µM 0.571265834501686 0.257261107627118 no 867 0.283909728734206 1363 6473075 SGTC_1907 st060210 83.7 µM 0.570396960335602 0.25757372996771 no 868 0.284204245377464 1448 688793 SGTC_1257 0669-0121 16 µM 0.570015524675902 0.257711033430966 no 869 0.284333584274565 1427 4307855 SGTC_2483 5729050 27.16 µM 0.569899683330004 0.257752739774419 no 870 0.284372869840736 1469 2865180 SGTC_2811 7967822 32.47 µM 0.568761326318426 0.258162768585377 no 871 0.284759061627264 1443 2232244 SGTC_1662 st014054 52 µM 0.567344636904037 0.258673522821297 no 872 0.28524002799472 1371 2838777 SGTC_439 amiodarone 34.4 µM 0.566782373930886 0.258876378497267 no 873 0.285431023636996 1417 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3186 9110464 49.47 µM 0.566335967781295 0.259037493439595 no 874 0.285582707119996 1412 17018021 SGTC_721 1187-1332 279 µM 0.565216266694326 0.259441839055033 no 875 0.285963336888279 1335 25730 SGTC_2182 6325192 200 µM 0.564432599807322 0.259725030062881 no 876 0.286229878979041 1341 736248 SGTC_568 1193-0097 7.48 µM 0.564362805660733 0.259750259068185 no 877 0.286253623201351 1315 3646150 SGTC_72 0744-0168 198.391 µM 0.563593939010292 0.260028270653479 no 878 0.286515256315782 1425 677577 SGTC_2204 7233102 200 µM 0.561876935655714 0.260649668844176 no 879 0.287099934516291 1371 2172480 SGTC_493 zm226600 134 µM 0.56151386481389 0.260781165114865 no 880 0.287223640614119 1418 5240098 A potassium channel opener. YCR052W RSC6 SGTC_415 dibenzyl ketone 100 µM 0.56054504874422 0.261132215956659 no 881 0.287553860645357 1483 7593 SGTC_2594 a-mangostin 100 µM 0.560327516908879 0.261211072070718 no 882 0.287628030831179 1465 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1691 st019933 84.6 µM 0.558956729519615 0.261708269038605 no 883 0.288095625744093 1408 6176082 SGTC_2302 7771753 200 µM 0.558618605559109 0.261830984271279 no 884 0.288211019726838 1339 2203047 SGTC_1400 3771-8998 51.5 µM 0.558208171491053 0.261979982636704 no 885 0.288351120785245 1395 670767 SGTC_812 4251-0442 148 µM 0.557642314446037 0.262185474887641 no 886 0.288544327880281 1389 5723007 SGTC_353 1988-1175 58.3 µM 0.556578593041839 0.262571991117121 no 887 0.288907691559155 1334 2788357 SGTC_874 0599-0792 117 µM 0.554393448296152 0.263366904102532 no 888 0.289654804465548 1441 765305 SGTC_291 SEC14.278 35.5 µM 0.55298584811118 0.263879611459387 no 889 0.290136550383142 1459 1068044 SGTC_3262 9137218 49.47 µM 0.552900846537737 0.263910588901123 no 890 0.290165653872067 1312 17650664 SGTC_2657 nystatin 74.44 µM 0.55222004473106 0.264158762915371 no 891 0.290398801339628 1433 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2344 7990960 76.95 µM 0.551793479320557 0.26431432019199 no 892 0.290544927659146 1418 140813 SGTC_727 3032-0951 202 µM 0.550986409451907 0.264608765062139 no 893 0.290821495530068 1413 3652836 SGTC_864 0469-0573 172 µM 0.550789098351201 0.264680775829052 no 894 0.290889129101696 1359 689425 SGTC_44 0929-0055 61.211 µM 0.550766472858197 0.264689033878228 no 895 0.290896885054574 1355 1379590 SGTC_61 0978-8327 98.565 µM 0.549802362430842 0.265041044995771 no 896 0.291227469061691 1420 6150059 YHR072W ERG7 SGTC_3114 9122766 49.47 µM 0.549771165413723 0.265052439463808 no 897 0.291238169141594 1354 17176985 SGTC_1881 5652484 16 µM 0.5488245185229 0.265398313186515 no 898 0.29156294118568 1444 2255129 SGTC_2761 levamisole 97.89 µM 0.548625351266336 0.265471111522418 no 899 0.291631292233654 1495 26879 An alkaline phosphatase inhibitor. SGTC_1260 0700-1617 7.75 µM 0.548351424577263 0.265571251992585 no 900 0.291725311734938 1443 2853078 SGTC_3266 9136860 49.47 µM 0.546090862814813 0.266398385376528 no 901 0.292501740155672 1357 4871271 YPR165W RHO1 SGTC_3346 9158254 43.5805 µM 0.545892716485233 0.266470948660426 no 902 0.292569842643501 1408 17639500 SGTC_3202 9113761 49.47 µM 0.543618411165739 0.267304538672915 no 903 0.293352043794462 1572 4798415 SGTC_1101 ebselen 5.29 µM 0.542604315815473 0.267676653762061 no 904 0.29370113341218 1479 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_182 3448-4371 550.524 µM 0.541366430967143 0.268131240402741 no 905 0.294127520156041 1492 3491403 SGTC_2555 cholic acid 100 µM 0.538593010402778 0.269151128022289 no 906 0.295083855747482 1420 6708657 Influences liver metabolism. SGTC_1967 st070177 51.4 µM 0.538013485518891 0.269364485981643 no 907 0.295283869247748 1497 5729214 SGTC_965 1291-5240 308 µM 0.537578262024195 0.26952477365981 no 908 0.295434120504881 1498 2834598 SGTC_2504 purpurogallin 52.29 µM 0.537349447583762 0.269609062485465 no 909 0.295513127716841 1408 5281571 An antioxidant. SGTC_2983 9022671 12.99 µM 0.53731998397736 0.269619917011829 no 910 0.295523301895319 1550 6405161 SGTC_1773 st048542 73.5835 µM 0.537216755651688 0.269657948522879 no 911 0.295558949291466 1346 3237138 SGTC_2351 9026858 72.31 µM 0.537200252388264 0.269664028925329 no 912 0.295564648476128 1362 1409300 SGTC_188 3229-0966 278.469 µM 0.535963731664491 0.270119803392178 no 913 0.295991808262929 1537 5722370 SGTC_3287 9117173 37.0625 µM 0.535944612131014 0.27012685376692 no 914 0.295998415387434 1405 2789709 SGTC_2958 9077254 16.72 µM 0.534793971558072 0.270551324682579 no 915 0.296396166066444 1436 16457351 SGTC_2267 7931562 200 µM 0.531769630901722 0.271668589425278 no 916 0.297442779402551 1333 934880 SGTC_1465 k213-0056 144 µM 0.530722197875169 0.272056071379426 no 917 0.297805650633805 1407 24048857 YMR208W ERG12 SGTC_638 3970-0837 4.09 µM 0.52790922822218 0.273098044909522 no 918 0.29878116968323 1414 4118451 YLR208W SEC13 SGTC_252 miconazole 1.30953 nM 0.527210799607287 0.273357061346431 no 919 0.299023604928218 1411 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1885 st057546 99.9 µM 0.525070358895486 0.27415161352564 no 920 0.299767140345821 1522 702008 SGTC_1826 st055655 41.6 µM 0.524190787734672 0.274478449201426 no 921 0.300072923833723 1462 676168 SGTC_169 k015-0017 16.025 µM 0.522544931173006 0.275090541277003 no 922 0.300645485624188 1527 1840002 SGTC_2076 5212012 200 µM 0.52092664777264 0.2756930336593 no 923 0.301208935572909 1404 604802 SGTC_27 0485-0001 32.618 µM 0.518492553023108 0.27660047518108 no 924 0.302057327283939 1421 2054479 SGTC_7 0192-1582 4.227 µM 0.518465738514034 0.276610479898212 no 925 0.302066679321858 1479 252616 SGTC_206 4546-0025 72.014 µM 0.513193837325631 0.278580908190593 no 926 0.303907868188493 1459 6620745 YIL048W NEO1 SGTC_2218 6965428 192.983 µM 0.510159543256196 0.279718098622348 no 927 0.304969846464434 1505 675684 SGTC_1750 st081859 2.357 µM 0.509877504153932 0.279823915334949 no 928 0.305068641537813 1490 5291695 SGTC_1784 st039334 36.3 µM 0.508239649154839 0.280438796726186 no 929 0.305642644067888 1551 3496984 SGTC_490 phenamil 164 µM 0.50757480142307 0.28068857950799 no 930 0.305875783015622 1525 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1251 0490-5699 265 µM 0.507525877163069 0.280706964564961 no 931 0.30589294215914 1553 3883818 SGTC_772 k072-0172 35.3 µM 0.505390205691707 0.28151008736876 no 932 0.306642398327263 1384 5861980 SGTC_1432 4049-0298 68.4 µM 0.505170818386467 0.281592651071178 no 933 0.306719432255579 1546 741646 SGTC_3173 9105693 49.47 µM 0.504141716992312 0.281980096466237 no 934 0.307080896716678 1515 17096658 SGTC_2309 7664088 163.95 µM 0.504127401167262 0.281985488027775 no 935 0.307085926370767 1514 704922 SGTC_2397 5161689 200 µM 0.504067662988152 0.282007986887565 no 936 0.307106914891109 1550 2259942 SGTC_935 2996-0153 430 µM 0.503766744458811 0.282121333312529 no 937 0.3072126497629 1497 23738523 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.503178083971189 0.282343126366122 no 938 0.307419535948873 1564 1377 SGTC_408 cantharidin 100 µM 0.50215392629033 0.282729204055577 no 939 0.307779624744926 1478 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2572 astragaloside iv 100 µM 0.501113844576286 0.283121544060291 no 940 0.308145501929495 1502 45006101 An anti-inflammatory agent. SGTC_3068 9116768 49.47 µM 0.499553567762714 0.283710601717484 no 941 0.308694729575377 1457 41904888 SGTC_3034 9090421 49.47 µM 0.499384870522162 0.283774325818231 no 942 0.308754137780354 1472 17173761 SGTC_502 l-744,832 89.3 µM 0.499383455485431 0.283774860366587 no 943 0.308754636119053 1545 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3330 9141424 71.43 µM 0.499014875542726 0.283914112604233 no 944 0.308884452265075 1562 27261020 SGTC_1993 st073995 70.8 µM 0.498148065162167 0.284241728831514 no 945 0.309189842356384 1497 3098394 SGTC_1710 st031758 61.5 µM 0.498114472815384 0.28425442889912 no 946 0.309201680091886 1562 5394341 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.497276750394574 0.284571229553027 no 947 0.309496952335188 1435 6708630 An antioxidant. SGTC_2192 5915882 198.485 µM 0.496978747243541 0.284683965751818 no 948 0.309602019259873 1469 2876149 SGTC_120 rhodamine 6G 52.259 µM 0.49511394110162 0.285389915670322 no 949 0.310259846767894 1461 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1854 st056233 32.9 µM 0.495104929199723 0.285393329282195 no 950 0.310263027275877 1538 5393174 SGTC_1872 amphotericin b 148 nM 0.495058741263168 0.285410825082854 no 951 0.310279328286469 1543 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1634 st006576 41 µM 0.493991717326607 0.285815151492613 no 952 0.310656014499359 1608 3915356 SGTC_2262 9014885 67.46 µM 0.492124155515324 0.286523479872601 no 953 0.3113157884698 1476 6457424 SGTC_3095 9117207 49.47 µM 0.492100583760174 0.286532425481647 no 954 0.311324119801857 1511 17015229 SGTC_3010 9080089 71.4286 µM 0.490919808224689 0.286980705674241 no 955 0.311741583262646 1575 17027233 SGTC_2176 5809774 33.9695 µM 0.49082674725948 0.287016050290621 no 956 0.311774495284515 1526 2870539 SGTC_2995 9067767 71.4286 µM 0.49028117912387 0.287223298892923 no 957 0.311967471619423 1511 11673567 SGTC_413 propylparaben 100 µM 0.490249146717521 0.287235469457624 no 958 0.311978803608188 1449 7175 A pharmaceutical preservative. SGTC_2069 5228469 200 µM 0.489442080153422 0.287542191181557 no 959 0.312264375335605 1446 2835210 SGTC_2532 xanthone 78.9 µM 0.489313511937939 0.287591067202265 no 960 0.31230987822267 1550 7020 An insecticide. SGTC_2828 7998861 71.43 µM 0.488425119388929 0.287928902528837 no 961 0.312624376482464 1573 2988188 SGTC_1959 st077091 55.8 µM 0.485824788770444 0.288918824085138 no 962 0.313545698642053 1484 821356 YKL052C ASK1 SGTC_3265 9137266 49.47 µM 0.483751921227169 0.289709090781874 no 963 0.314280970032313 1604 17224265 SGTC_2175 5807670 165.306 µM 0.483705205909516 0.289726912362484 no 964 0.314297549033687 1477 241186 SGTC_2843 9000894 45.46 µM 0.483638029328479 0.289752540679718 no 965 0.314321390278118 1415 2242070 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.482725241130685 0.290100880893036 no 966 0.314645419292603 1445 4000243 SGTC_856 0433-0016 11.3 µM 0.482555065837471 0.290165845257595 no 967 0.314705845309126 1512 3911780 SGTC_73 0327-0325 16.231 µM 0.482058929017368 0.290355284228278 no 968 0.314882042395015 1552 53298 SGTC_297 0986-0032 24 µM 0.481963360922722 0.290391781461634 no 969 0.314915987108288 1478 2847425 SGTC_2919 7978188 46.38 µM 0.481163175994106 0.290697454476518 no 970 0.315200265132351 1617 2980291 SGTC_2064 5220758 200 µM 0.479577393144112 0.291303672438672 no 971 0.31576396223607 1549 788518 SGTC_1565 sinapyl alcohol 95.1 µM 0.477561303418248 0.292075240226737 no 972 0.316481239281125 1443 5280507 A phenol propionate derived from cinnamic acid. SGTC_3061 glucosamine 200 µM 0.475274607014173 0.292951520115732 no 973 0.317295627924572 1557 91431 and experimental redox chemotherapeutic SGTC_3150 9097574 49.47 µM 0.474908349430122 0.293091986148178 no 974 0.317426150000095 1634 17217476 SGTC_3315 9136395 68.55 µM 0.473936574030155 0.293464829908428 no 975 0.31777256857847 1576 16876844 SGTC_1583 clindamycin 39.6 µM 0.47330617181969 0.293706815497127 no 976 0.317997379768949 1444 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_111 0083-0039 52.457 µM 0.472111056624533 0.294165824576824 no 977 0.318423760448388 1480 759313 SGTC_1490 4089-0339 670 nM 0.470299623284877 0.294862174788031 no 978 0.319070483294771 1578 742542 SGTC_3312 9133330 71.43 µM 0.469869170682549 0.295027760800792 no 979 0.319224245764807 1602 17617324 SGTC_2717 st081029 62.2815 µM 0.469850420856639 0.295034974435748 no 980 0.31923094411878 1537 5292846 SGTC_2075 5212009 200 µM 0.469421666291005 0.295199951676283 no 981 0.319384132298927 1568 780898 SGTC_3157 9099274 49.47 µM 0.467400149793254 0.295978367337522 no 982 0.320106807724941 1553 17217662 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.467263410559745 0.296031054868291 no 983 0.320155715563278 1488 6708760 SGTC_2605 digitonin 300 nM 0.464997595622205 0.296904730892407 no 984 0.320966589212281 1581 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1151 3909-8316 15.3 µM 0.464591154070981 0.297061575488081 no 985 0.321112134120884 1515 800431 SGTC_3283 9109332 35.8195 µM 0.46410929577433 0.297247572257327 no 986 0.321284721037495 1478 17027281 SGTC_895 0964-0006 13.7 µM 0.463605477808629 0.29744210233004 no 987 0.321465214515561 1513 6738897 SGTC_659 k018-0002 107 µM 0.459727096148186 0.298941533798949 no 988 0.322856058939837 1635 6797879 YHR007C ERG11 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.459308462405137 0.299103588002166 no 989 0.323006335838337 1567 4213774 SGTC_1081 sertraline 6 µM 0.457582647823027 0.299772075950243 no 990 0.323626156167762 1628 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1903 st060211 78.3 µM 0.456107029313358 0.300344187339016 no 991 0.32415650783055 1651 688960 SGTC_1361 1608-0041 5.61 µM 0.455703904337602 0.300500568510312 no 992 0.324301457009574 1521 X1361 SGTC_1186 1319-0216 26 µM 0.454825367332889 0.300841499944823 no 993 0.324617439412891 1680 4565136 SGTC_1690 st023502 41.2 µM 0.454441874807815 0.300990375515505 no 994 0.324755409337876 1617 24207482 SGTC_2709 st078560 56 µM 0.451437459155669 0.302157866738397 no 995 0.325837145261503 1665 17250903 SGTC_1644 st010134 20.9 µM 0.450675611025739 0.302454237436726 no 996 0.326111681338369 1566 3818134 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.450594822255537 0.302485673159671 no 997 0.326140799537854 1575 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2890 9046729 58.44 µM 0.450075217388446 0.302687891637256 no 998 0.326328102850301 1476 903329 SGTC_430 0958-0115 16.4 µM 0.449504720732368 0.302909985774863 no 999 0.326533801710537 1558 6833180 SGTC_3136 9095672 49.47 µM 0.449051652266511 0.303086417112589 no 1000 0.326697198129817 1597 17217380 SGTC_129 0088-0017 176.636 µM 0.448664148016305 0.303237353269735 no 1001 0.326836975587731 1631 182446 SGTC_3291 9121177 71.43 µM 0.448620203198569 0.303254472266418 no 1002 0.326852828548312 1522 17015612 SGTC_1693 xanthone 101.9 µM 0.447188274231004 0.30381252596834 no 1003 0.327369563479608 1588 7020 An insecticide. SGTC_404 fumagillin 50 µM 0.446940280081072 0.303909221180173 no 1004 0.327459089864732 1571 12015870 A methionine aminopeptidase binder. SGTC_1113 artemisinin 1.17947 µM 0.446373574904366 0.304130236266613 no 1005 0.327663708810564 1656 2240 An anti-malaria and mitochondrial poison. SGTC_1498 4478-3555 97.6 µM 0.444098374723427 0.305018284642398 no 1006 0.328485730742892 1597 3437919 SGTC_893 0958-0369 48.9 µM 0.44356521370585 0.305226552668988 no 1007 0.328678480278245 1692 6819948 SGTC_2905 7799065 20.05 µM 0.443512111834865 0.305247299242118 no 1008 0.328697680279737 1642 1296806 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.443347334490521 0.305311680716125 no 1009 0.328757261572238 1539 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.443072387135674 0.305419121005308 no 1010 0.328856688563266 1534 16486 A toxic proline analog. SGTC_1825 st052143 62.6 µM 0.442468214396549 0.305655270509966 no 1011 0.329075213215693 1622 674173 SGTC_2381 9035592 200 µM 0.442338347171435 0.305706041522405 no 1012 0.329122192827584 1483 4749657 SGTC_333 3486-0131 40.1 µM 0.442047438127632 0.305819784669359 no 1013 0.329227439287908 1679 6744690 SGTC_2428 5615643 7.78 µM 0.441539898005871 0.306018273711831 no 1014 0.329411091974501 1594 2253075 SGTC_3096 9117468 49.47 µM 0.441400526025196 0.306072789348272 no 1015 0.329461530736701 1518 41316311 SGTC_2474 5321570 43.32 µM 0.440675647225642 0.306356396424763 no 1016 0.329723914616131 1648 2841384 SGTC_2299 7976368 114.88 µM 0.44041765233223 0.306457364313649 no 1017 0.329817321082975 1672 2979718 SGTC_2469 5655019 90.81 µM 0.43988518274304 0.306665796019097 no 1018 0.330010134044654 1687 2788239 SGTC_1762 st045503 25.4615 µM 0.438639330020158 0.3071537211036 no 1019 0.330461447103323 1559 4645554 SGTC_1313 1220-0047 237 µM 0.437993782397483 0.307406677458819 no 1020 0.330695395306058 1632 3528706 SGTC_2336 9001819 198.65 µM 0.437593614324527 0.307563528416137 no 1021 0.330840450517932 1661 2989602 SGTC_1413 3910-0535 34.4 µM 0.437238151221198 0.307702886206397 no 1022 0.330969322121953 1650 2876951 SGTC_396 dithiazanine 1.25 µM 0.437128290018387 0.30774596243582 no 1023 0.331009155876563 1526 10578 An antihelmenthic. SGTC_1748 st037455 53.6035 µM 0.436782060089303 0.307881735428857 no 1024 0.331134705318359 1623 580690 SGTC_167 3672-0051 66.205 µM 0.434270483936738 0.308867428869937 no 1025 0.33204601745676 1512 3237971 SGTC_8 0354-0001 70 µM 0.433027692972471 0.309355684942475 no 1026 0.332497325692509 1599 4993152 SGTC_130 0136-0219 337.655 µM 0.432719114722037 0.30947696850242 no 1027 0.332609420749107 1653 234244 SGTC_2369 9071472 200 µM 0.43091417488066 0.310186797250053 no 1028 0.333265388147629 1629 17296037 SGTC_1850 st056238 17 µM 0.430325299409339 0.310418537592496 no 1029 0.333479513052723 1549 5393177 SGTC_2696 st077691 74.316 µM 0.429896861199474 0.310587188324373 no 1030 0.333635334411725 1593 757133 SGTC_2139 5578692 56.4705 µM 0.429304317554856 0.310820503252206 no 1031 0.333850887591667 1684 650991 YMR113W FOL3 SGTC_1169 aniline yellow 25.8 µM 0.427998830226493 0.311334809176688 no 1032 0.334325986022168 1650 6051 A DNA damaging agent. SGTC_1215 3852-0577 11.2 µM 0.427396234864547 0.311572330219778 no 1033 0.334545374667821 1697 2884876 SGTC_2610 ononetin 44.17 µM 0.426725187345877 0.311836924899914 no 1034 0.334789751390031 1539 259632 SGTC_3328 9140624 29.0385 µM 0.426410084751946 0.311961203682792 no 1035 0.334904527087869 1706 4904392 SGTC_1980 st071811 45.7 µM 0.426328496052332 0.311993386356604 no 1036 0.334934248176475 1644 4974850 SGTC_1201 1889-3372 45.9 µM 0.425641159072821 0.312264563477387 no 1037 0.335184671954464 1587 5392199 SGTC_387 norethindrone acetate 66.7 µM 0.42325068928658 0.31320847411149 no 1038 0.336056183653773 1582 541197 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.421315951320612 0.31397333014715 no 1039 0.336762191898513 1558 16623 A steroid. SGTC_1329 1447-1697 50.6 µM 0.42072288094958 0.314207947785908 no 1040 0.336978725522362 1594 2840515 SGTC_1035 k081-0041 55.2 µM 0.420258226707406 0.314391816690454 no 1041 0.337148411386603 1672 731709 SGTC_3071 9117417 49.47 µM 0.419044853516643 0.314872179175642 no 1042 0.337591676140288 1697 45595590 YGL055W OLE1 SGTC_218 alverine citrate 93.75 µM 0.419016328193698 0.314883475842966 no 1043 0.337602099614161 1650 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2525 harmine 47.85 µM 0.418494380262017 0.315090209494406 no 1044 0.337792847248703 1663 5280953 A monoamine oxidase inhibitor SGTC_1091 telmisartan 47.6 µM 0.416839282743053 0.315746145028171 no 1045 0.338397983590763 1678 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_466 geldanamycin 89.2 µM 0.41639866333117 0.315920865897294 no 1046 0.338559153197261 1673 5288382 HSP90 inhibitor. SGTC_2406 ethylparaben 405.7 µM 0.415554496174658 0.316255722299858 no 1047 0.338868014930811 1418 8434 A possible steroid mimic. SGTC_2616 abietic acid 100 µM 0.414519202604586 0.316666598745838 no 1048 0.33924695343912 1700 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2782 7736369 71.43 µM 0.41442125692436 0.316705482124525 no 1049 0.339282811978006 1607 2950836 YOL077C BRX1 SGTC_2640 pentamidine 10.38 µM 0.413856652475232 0.316929663477173 no 1050 0.339489545641456 1736 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_953 1188-0045 9.7 µM 0.413669148469607 0.317004128529207 no 1051 0.339558212165644 1657 6144426 SGTC_794 k038-0031 316 µM 0.413413859144623 0.317105525654133 no 1052 0.339651711160555 1591 6624242 SGTC_2104 5389443 200 µM 0.41230726489656 0.317545207148794 no 1053 0.340057112215091 1694 2244536 SGTC_1279 0874-0590 65.2 µM 0.41205614609579 0.317645019689735 no 1054 0.340149135415391 1632 3523074 SGTC_2488 5268135 45.7 µM 0.411534708226772 0.317852318662586 no 1055 0.340340248219058 1664 1270356 YLR208W SEC13 SGTC_1969 st069479 40.1 µM 0.410029718292824 0.318450951351061 no 1056 0.340892073713884 1681 3895485 SGTC_3260 9137109 49.47 µM 0.409941153875602 0.318486193989804 no 1057 0.340924557712021 1702 17478346 SGTC_1209 2323-2347 50.3 µM 0.406766992084074 0.31975037762994 no 1058 0.342089565983945 1659 5412760 SGTC_497 capsazepine 133 µM 0.406566336245497 0.319830364092394 no 1059 0.342163263107706 1527 2733484 A calcium channel blocker. SGTC_23 0213-0011 39.996 µM 0.405794949402534 0.320137936273743 no 1060 0.342446634981967 1714 627608 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.405331997955802 0.320322586550455 no 1061 0.342616744554828 1584 390807 SGTC_3306 9127676 59.7925 µM 0.404025793334911 0.320843811932193 no 1062 0.343096875984471 1588 41905287 SGTC_2466 5983409 37.09 µM 0.403165447695017 0.321187315683417 no 1063 0.343413258174181 1608 2879657 SGTC_2589 lobaric acid 100 µM 0.402531255942877 0.321440622676088 no 1064 0.343646545164179 1572 73157 A novel microtubule depolymerizer. SGTC_1618 st003135 44.5 µM 0.402393012654115 0.321495850431837 no 1065 0.34369740577025 1638 1270615 SGTC_3083 9117465 49.47 µM 0.401260320805863 0.321948505761873 no 1066 0.34411423696553 1575 16420915 SGTC_760 0568-0725 82.9 µM 0.399309451033848 0.322728747256012 no 1067 0.344832602059849 1746 3916171 SGTC_844 0330-0132 15.3 µM 0.398752912788402 0.322951475547831 no 1068 0.34503763782072 1694 2828079 SGTC_1715 st032160 10.2275 µM 0.398586793421732 0.323017969332673 no 1069 0.345098847127297 1709 5289825 SGTC_2642 cholecalciferol 100 µM 0.398510845546811 0.323048371415167 no 1070 0.345126832672511 1672 9821465 A vitamin D precursor, similar to steriods. SGTC_1520 flindersine 88 µM 0.398256340856401 0.323150258756879 no 1071 0.345220619647463 1792 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_780 0109-0199 192 µM 0.398206757210467 0.323170110410601 no 1072 0.345238892716593 1760 610414 SGTC_351 caspofungin 25 nM 0.398060663997398 0.323228604234259 no 1073 0.345292734569723 1703 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_210 3551-0445 56.827 µM 0.397364674149169 0.323507329511125 no 1074 0.345549280789024 1675 2865180 YOR207C RET1 SGTC_1470 k295-0292 231 µM 0.397219061343192 0.323565656071852 no 1075 0.345602963561363 1711 5045612 SGTC_486 niguldipine 82 µM 0.396593867168278 0.323816132647708 no 1076 0.345833487880696 1650 1236 A calcium channel blocker. SGTC_752 1896-0090 130 µM 0.395738492475211 0.324158957584093 no 1077 0.346148977957916 1628 772567 SGTC_2211 7117706 200 µM 0.394519862992185 0.324647628684819 no 1078 0.346598632683929 1706 822771 SGTC_41 0478-0632 82.643 µM 0.393238993197468 0.325161583742239 no 1079 0.347071486157925 1750 3750424 SGTC_634 1611-4317 11.2 µM 0.392340703585993 0.325522225310109 no 1080 0.347403246228736 1720 2843522 SGTC_2099 5377090 177.372 µM 0.39227096847626 0.32555022911051 no 1081 0.347429005985261 1618 2243829 SGTC_2914 7968218 45.32 µM 0.392009185428676 0.325655363137098 no 1082 0.347525713454659 1728 2977111 SGTC_3003 9075612 71.4286 µM 0.391801348427703 0.325738841905928 no 1083 0.34760249933085 1647 6501993 SGTC_985 1493-0307 8.71 µM 0.389149884967652 0.32680458108502 no 1084 0.348582636598156 1768 3278274 SGTC_1670 st016595 4.04 µM 0.386144922872147 0.328014116784516 no 1085 0.349694670682011 1660 597879 SGTC_2981 9013952 38.96 µM 0.385890454935419 0.328116626499398 no 1086 0.349788900010805 1534 2996344 SGTC_899 1083-0020 478 µM 0.385465779022982 0.328287731526018 no 1087 0.34994617785893 1745 767123 SGTC_1763 st044482 94.5 µM 0.384485359446438 0.328682887284806 no 1088 0.350309372523877 1704 88505 SGTC_1474 0330-0125 5.35 µM 0.384438710392642 0.328701693853362 no 1089 0.350326656996852 1629 X1474 SGTC_465 cgp-37157 41 µM 0.382980050266812 0.329289971425158 no 1090 0.350867278018156 1730 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1971 st069429 63.5 µM 0.382145059505634 0.329626913589186 no 1091 0.35117688541967 1763 1246522 YGL099W LSG1 SGTC_1516 st013856 110 µM 0.382008389384874 0.329682076993719 no 1092 0.35122757094123 1646 5281404 A mutagen and neurotoxin. SGTC_126 0417-1624 672.48 µM 0.381004866583973 0.330087236775843 no 1093 0.351599818705926 1788 41912 YDL195W SEC31 SGTC_478 N-arachidonylglycine 10 µM 0.378874645136594 0.330947947333656 no 1094 0.352390476630814 1701 5283389 SGTC_1682 st012968 530 nM 0.378459550810528 0.331115769390733 no 1095 0.352544618415901 1600 24207270 SGTC_1352 1496-0991 99 µM 0.377615800198331 0.331457001146048 no 1096 0.352858012723716 1644 3000039 SGTC_1677 st019204 53.9 µM 0.37586772653702 0.332164406598276 no 1097 0.353507617326947 1597 3945625 SGTC_2020 4017018 200 µM 0.375523930533435 0.332303603488649 no 1098 0.353635426236384 1652 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3299 9121982 43.1275 µM 0.374509283617185 0.332714550825954 no 1099 0.354012725497013 1621 17594604 YPL160W CDC60 SGTC_319 1348-1596 45.5 µM 0.374461182012496 0.332734037698866 no 1100 0.354030615774534 1780 5380505 SGTC_2082 5219693 150 µM 0.373349856522484 0.333184382479529 no 1101 0.354444037198987 1617 2834649 SGTC_2446 5162541 200 µM 0.372572512164382 0.33349953044946 no 1102 0.354733317137344 1626 1549321 SGTC_2378 9074213 121.43 µM 0.372473100991136 0.333539841828039 no 1103 0.354770317930904 1653 657714 SGTC_287 k060-0039 29.6 µM 0.371164657961021 0.334070596407879 no 1104 0.355257447405072 1769 5861974 SGTC_1665 st014639 11.4 µM 0.370745813243802 0.334240566062591 no 1105 0.355413432087836 1732 981133 YIL048W NEO1 SGTC_2492 derrusnin 100 µM 0.370676034630245 0.334268885939589 no 1106 0.355439421149359 1631 1715307 Part of coumarin class of compounds. SGTC_2187 6125751 200 µM 0.37032022815998 0.33441330581816 no 1107 0.355571951806028 1692 874498 SGTC_3045 9092950 49.47 µM 0.368963148989797 0.334964361610652 no 1108 0.356077596335646 1794 44120432 SGTC_2288 7946289 167.31 µM 0.367587329578267 0.335523389990145 no 1109 0.356590481947235 1798 1246052 SGTC_2915 7971052 15.16 µM 0.366365434373042 0.336020180787328 no 1110 0.357046204396259 1660 5741558 SGTC_2701 st077767 14.721 µM 0.365877619753801 0.336218593615282 no 1111 0.357228198525019 1665 5721188 SGTC_2462 5162487 171.77 µM 0.365101786451484 0.336534248620478 no 1112 0.35751771371462 1785 2259986 SGTC_1558 st069300 45.6 µM 0.364745416500477 0.336679279688771 no 1113 0.357650726629018 1778 24208000 SGTC_1198 1612-1005 86.7 µM 0.364491495891909 0.336782632004635 no 1114 0.357745511500085 1771 6998509 SGTC_358 0075-0058 9.45 µM 0.362419353968602 0.337626508016728 no 1115 0.358519339390768 1927 1069125 SGTC_425 3825-7017 13.1 µM 0.362390746438189 0.337638164108877 no 1116 0.358530026761521 1744 3397440 SGTC_849 0386-0493 241 µM 0.362311929034933 0.337670278938447 no 1117 0.358559472407262 1671 726119 SGTC_1745 st081495 74 µM 0.361107525347097 0.338161170513156 no 1118 0.359009533938482 1716 13842402 YBL026W LSM2 SGTC_655 k060-0012 42 µM 0.36073012678284 0.33831504752646 no 1119 0.359150600534458 1660 5994525 SGTC_878 0828-0289 13.7 µM 0.360209901030337 0.338527203850571 no 1120 0.359345085526494 1675 745350 YLR208W SEC13 SGTC_3041 9091929 49.47 µM 0.359948673605798 0.338633755879035 no 1121 0.359442758442435 1729 25236887 SGTC_1439 4092-1168 46 µM 0.357658299678919 0.339568528576176 no 1122 0.360299521734719 1720 2886240 SGTC_2907 7721985 69.9 µM 0.357209885988124 0.339751655928219 no 1123 0.3604673427653 1641 3267881 SGTC_155 k072-0202 43.6 µM 0.356845441684579 0.339900518950999 no 1124 0.360603757644298 1772 5857737 SGTC_1066 ketoconazole 628 nM 0.35637851270563 0.340091279940998 no 1125 0.360778559411757 1767 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1471 k673-0312 37 µM 0.354659348852907 0.340793986417692 no 1126 0.361422404289236 1733 24099884 SGTC_2860 9025725 38.96 µM 0.354392632143108 0.340903056197684 no 1127 0.361522327720804 1625 40546248 SGTC_1756 st041558 35.5 µM 0.354037251695982 0.341048404341951 no 1128 0.361655483038265 1862 3955792 SGTC_525 k781-2675 26.7 µM 0.352462348343978 0.341692812599914 no 1129 0.362245775346152 1715 3651118 YDL195W SEC31 SGTC_1953 st076800 12.1 µM 0.351261729066672 0.342184384067269 no 1130 0.362696001821228 1639 297591 SGTC_1974 st069448 26.9 µM 0.349659607419642 0.342840759927737 no 1131 0.36329708546081 1818 6323587 YNR016C ACC1 SGTC_1739 st037196 92.5 µM 0.348466398978312 0.343329915994394 no 1132 0.363744972050228 1847 612214 SGTC_257 daunorubicin 18.5 µM 0.348309838115756 0.34339411765821 no 1133 0.363803753078701 1832 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_883 0850-0245 24.6 µM 0.34768956144755 0.343648521890433 no 1134 0.364036668450104 1807 6823229 YPR165W RHO1 SGTC_2794 7785382 27.27 µM 0.346524133526587 0.344126709428221 no 1135 0.364474425225107 1874 2205081 SGTC_2130 NSC 7 2.4545 µM 0.346412434384113 0.344172553887609 no 1136 0.364516390830327 1817 21448 SGTC_274 sirtinol 40.1 µM 0.345873285598514 0.344393867858512 no 1137 0.364718973001794 1642 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_609 0986-0026 86.3 µM 0.345177458376917 0.344679575167792 no 1138 0.364980482065245 1763 2848610 SGTC_2730 imipramine 71.33 µM 0.344857272549356 0.344811073548351 no 1139 0.365100836920977 1789 3696 A tricyclic antidepressant. SGTC_2744 captopril 92.04 µM 0.34208727376755 0.34594947653484 no 1140 0.36614260720685 1833 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.341536221190692 0.346176112466642 no 1141 0.366349970863157 1898 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2141 5621638 7.665 µM 0.340894273983272 0.346440200863002 no 1142 0.366591587807605 1838 2856238 SGTC_3322 9139058 2.11 µM 0.340213572903383 0.346720313639301 no 1143 0.366847848749401 1770 4908926 YPR165W RHO1 SGTC_2741 miltefosine 3.04 µM 0.340198426419042 0.346726547466661 no 1144 0.366853551564067 1725 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2000 st075254 36.4 µM 0.339708210263625 0.346928327764847 no 1145 0.367038139091783 1686 17234175 SGTC_809 3998-0021 90 µM 0.339059691096994 0.347195334653704 no 1146 0.36728238176098 1835 715485 SGTC_2056 5235370 200 µM 0.338914629175929 0.347255069617149 no 1147 0.36733702174986 1691 5511916 SGTC_3257 9139206 32.98 µM 0.33861190225044 0.347379741581404 no 1148 0.367451057540426 1792 4910041 SGTC_2043 5101342 149 µM 0.337831599772506 0.347701169495396 no 1149 0.367745047643757 1741 678451 SGTC_66 0109-0187 42.4 µM 0.337773946524439 0.347724922790913 no 1150 0.367766772405328 1621 759417 SGTC_249 wiskostatin 11.211 µM 0.337145093634731 0.347984050698212 no 1151 0.368003762735195 1815 2775510 A n-wasp and actin depolymerizer. SGTC_124 0136-0217 7.121 µM 0.336417895040864 0.348283791900347 no 1152 0.368277878404768 1875 3976905 SGTC_1121 fusaric acid 630.51 nM 0.336285341048388 0.348338439041377 no 1153 0.368327851527397 1680 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3190 9110366 49.47 µM 0.335155535568464 0.348804344010461 no 1154 0.368753880804066 1865 17123768 SGTC_1757 st041620 31.8375 µM 0.334567008993634 0.349047128800998 no 1155 0.368975867510847 1697 5289815 SGTC_2707 st078556 66.6 µM 0.334232796849637 0.349185028813424 no 1156 0.369101948663479 1864 17250899 SGTC_3242 9133940 49.47 µM 0.332738743184435 0.349801736883265 no 1157 0.369665750756072 1773 17248444 SGTC_1708 st033234 31.827 µM 0.332008330232348 0.350103377529556 no 1158 0.369941484423036 1807 674664 SGTC_2046 4110841 106 µM 0.331784503903028 0.350195830649318 no 1159 0.370025993105887 1849 44119630 YMR134W ERG29 SGTC_122 0236-0016 402.397 µM 0.331434156260369 0.350340562156441 no 1160 0.370158284234607 1741 6808838 SGTC_2857 9024691 58.44 µM 0.331123582967015 0.350468880725161 no 1161 0.370275569430616 1723 16478292 SGTC_2193 5925765 200 µM 0.33040258316846 0.350766839670677 no 1162 0.370547894972779 1798 877370 SGTC_2235 salicylic acid 500 µM 0.330096332672912 0.350893427934332 no 1163 0.370663587088886 1769 338 A COX inhibitor and kinase inhibitor. SGTC_1501 4491-0275 38.4 µM 0.329554733122716 0.351117337951948 no 1164 0.370868215540985 1830 5104718 SGTC_2916 7875993 68.79 µM 0.328679971886695 0.351479094016594 no 1165 0.371198797065299 1895 1299250 SGTC_1021 4476-0760 85.3 µM 0.328516672651534 0.351546641060367 no 1166 0.37126052010977 1661 746768 SGTC_1222 0366-0074 1.18 µM 0.328486244594874 0.351559227830249 no 1167 0.371272021523512 1861 286520 SGTC_1475 4092-1048 11.7 µM 0.328112799422857 0.351713719184584 no 1168 0.371413188352064 1724 2881759 SGTC_3105 9121040 49.47 µM 0.326395368365942 0.35242452197453 no 1169 0.372062620667943 1828 41448907 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.32439424136916 0.353253390027157 no 1170 0.37281978947799 1805 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1084 voriconazole 435 nM 0.323161317279973 0.353764415032954 no 1171 0.373286537395265 1873 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1937 st074714 47.2 µM 0.323077988901701 0.353798962677256 no 1172 0.373318089726554 1643 17250970 SGTC_912 3474-0017 2.18 µM 0.320783649866188 0.35475065940166 no 1173 0.374187175325317 1832 3360550 SGTC_2923 7992654 58.14 µM 0.31995363952449 0.355095173249205 no 1174 0.374501737442443 1734 2985126 SGTC_1044 1222-0021 1.78 µM 0.319478326705401 0.355292515550432 no 1175 0.374681911876043 1799 4306703 SGTC_1863 st057641 20.1 µM 0.317702549083119 0.356030133081143 no 1176 0.375355288719217 1880 3921635 SGTC_1649 st011737 51.3 µM 0.317567545044252 0.356086232768246 no 1177 0.375406497967695 1742 1761035 SGTC_352 k048-0007 5.11 µM 0.316190266204924 0.356658726158813 no 1178 0.375929047747265 1775 6811911 SGTC_3332 9141069 11.198 µM 0.315747718679791 0.356842748499102 no 1179 0.376097001912714 1691 17332883 SGTC_3278 9139605 49.47 µM 0.315498750571744 0.356946290319255 no 1180 0.376191499779398 1847 7958859 SGTC_2350 9023895 38.85 µM 0.315134152544522 0.357097939772815 no 1181 0.376329899314062 1816 2997209 SGTC_519 k048-0011 62.8 µM 0.314963757057468 0.357168821137514 no 1182 0.376394586017758 1795 6836379 SGTC_620 0109-0052 432 µM 0.314675809565865 0.357288613160051 no 1183 0.376503906509407 1854 493037 SGTC_3264 9137442 49.47 µM 0.312371105752467 0.358247922854588 no 1184 0.377379253385581 1855 17015726 SGTC_2061 5245884 80.95 µM 0.311694985051533 0.358529521431039 no 1185 0.377636169788285 1742 573863 SGTC_2790 5423970 71.43 µM 0.311587303370512 0.358574377050595 no 1186 0.37767709232135 1870 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_695 3505-6186 243 µM 0.311079215842958 0.358786051069855 no 1187 0.377870200586101 1802 1819379 SGTC_2303 7774051 200 µM 0.310075883915184 0.359204175894312 no 1188 0.378251625452921 1853 2953184 SGTC_2967 9089538 49.85 µM 0.304800965109975 0.361405190292184 no 1189 0.380258873215565 1942 728216 SGTC_3354 9151612 71.43 µM 0.30391404331876 0.361775720796523 no 1190 0.380596689259307 1886 27261949 SGTC_979 1426-2828 121 µM 0.302787176659067 0.362246680330329 no 1191 0.381026028258645 1850 747872 SGTC_579 4491-1009 110 µM 0.300689495777332 0.363123934383073 no 1192 0.381825639738737 1953 1271041 SGTC_2986 9022445 71.43 µM 0.300003617081825 0.363410926245928 no 1193 0.38208719830086 1900 6459286 SGTC_1497 4476-2978 41.3 µM 0.299563906364182 0.363594954520465 no 1194 0.382254909485067 1816 1528379 SGTC_2760 etidronate 98.04 µM 0.299402842777739 0.363662370931419 no 1195 0.382316346687461 1747 3305 A chelator and antioxidant. SGTC_2372 9071633 200 µM 0.299280933104477 0.363713401489825 no 1196 0.382362850721888 1896 21321366 SGTC_2083 5306046 65.942 µM 0.298376856225618 0.364091917304505 no 1197 0.382707775542287 1759 539837 SGTC_176 1486-1328 72.834 µM 0.298286210915606 0.364129875694034 no 1198 0.382742363819406 1724 22310231 SGTC_2648 atorvastatin 78.68 µM 0.297851883982442 0.364311771776991 no 1199 0.38290810649421 1864 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1412 3909-8563 178 µM 0.297197164186939 0.364586026124981 no 1200 0.383157993385409 1909 23767530 SGTC_3178 9107506 49.47 µM 0.297156974816997 0.364602863234516 no 1201 0.383173334046529 1814 8897194 SGTC_3238 9133470 49.47 µM 0.296971682864078 0.364680493629257 no 1202 0.3832440640997 1887 3534688 SGTC_2910 7948405 25.97 µM 0.296898323483157 0.364711229998334 no 1203 0.383272068080109 1908 2971328 SGTC_1173 0443-0020 122 µM 0.295522579872458 0.365287804726419 no 1204 0.383797352963637 1756 5331295 SGTC_1388 3346-4487 254 µM 0.294610466897717 0.365670239677837 no 1205 0.38414573272977 1842 3345614 SGTC_2360 9040895 200 µM 0.294291214634476 0.365804128818496 no 1206 0.384267692641485 1751 4914414 SGTC_442 cape 100 µM 0.293553834291227 0.366113436448516 no 1207 0.384549428525204 1905 5281787 SGTC_3087 9117406 49.47 µM 0.293415979391569 0.366171271861049 no 1208 0.384602106448292 1789 42546093 SGTC_2819 7996655 46.38 µM 0.292113171239982 0.366717999776279 no 1209 0.385100048239074 1875 6456960 SGTC_1359 1582-0056 520 nM 0.291988137861333 0.366770484707051 no 1210 0.385147846793869 1836 3661189 SGTC_625 k213-0058 121 µM 0.291659706872046 0.366908361177612 no 1211 0.385273409790703 1846 3655420 SGTC_594 1487-1584 10.8 µM 0.290771283560692 0.367281410368391 no 1212 0.385613124622528 1725 5013332 SGTC_2268 7933382 153.85 µM 0.2894289343671 0.367845300774372 no 1213 0.386126577803531 1892 935025 YOR257W CDC31 SGTC_2661 dactinomycin 12.96 µM 0.288485277122594 0.368241880396258 no 1214 0.386487649426444 1824 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_89 0302-0250 142.109 µM 0.288456271355021 0.368254072532444 no 1215 0.386498749463704 1833 4203518 YLR208W SEC13 SGTC_1794 st048918 76.9 µM 0.286882547935491 0.368915761974759 no 1216 0.387101126902052 1929 672303 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.286622326739477 0.369025212362799 no 1217 0.387200758564214 1937 756377 SGTC_1898 st060199 18.6 µM 0.285546527885065 0.369477811582447 no 1218 0.387612731664938 1767 688866 SGTC_1079 idarubicin 2.36 µM 0.285244459547444 0.369604927282077 no 1219 0.387728430370317 1907 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2881 9058953 51.95 µM 0.284206884810762 0.370041665568624 no 1220 0.388125919805762 1798 17122249 SGTC_1259 0671-0132 43 µM 0.283782944863238 0.370220159595558 no 1221 0.388288362731864 1786 X1259 SGTC_1994 st072947 40.9 µM 0.28351054575618 0.370334864209003 no 1222 0.388392749405705 1850 5286565 YDL195W SEC31 SGTC_2870 9038528 12.99 µM 0.282434122597209 0.370788248250281 no 1223 0.388805326748242 1801 6463316 SGTC_1891 st059073 26.2 µM 0.28135221387895 0.37124412363433 no 1224 0.389220133035969 1956 688754 SGTC_984 1492-0255 2.91 µM 0.279237891318973 0.372135540276508 no 1225 0.390031133295776 1834 1585198 SGTC_943 3253-1379 105 µM 0.278844666842074 0.372301402873233 no 1226 0.390182017107219 1888 668464 SGTC_3179 9107801 49.47 µM 0.278407044948238 0.372486020212129 no 1227 0.390349956063369 1772 4818259 SGTC_2927 9011802 47.9 µM 0.277075576725564 0.373047900036415 no 1228 0.390861037436229 1738 43912568 SGTC_3213 9129884 49.47 µM 0.27638254509084 0.373340466482976 no 1229 0.39112713089846 1708 17190742 SGTC_254 nsc-64875 3.808 µM 0.27607701008347 0.37346947267794 no 1230 0.391244459009839 1936 56993 SGTC_2920 7982904 15.77 µM 0.27262105396728 0.374929666947139 no 1231 0.392572263028578 1800 6456808 SGTC_537 1334-0398 209 µM 0.272104992163451 0.375147865453526 no 1232 0.392770645567503 1968 5846986 SGTC_2102 5377816 72.7585 µM 0.268942993644985 0.376485674950949 no 1233 0.393986775628117 1943 1379702 SGTC_606 k015-0008 38.6 µM 0.268678769513508 0.376597532948931 no 1234 0.39408844535062 1946 1970475 SGTC_2947 9072639 7.68 µM 0.267532891250712 0.377082754726701 no 1235 0.394529446601357 1775 16488146 SGTC_3132 9126706 49.47 µM 0.266945153120559 0.377331707631388 no 1236 0.394755695247294 1861 850858 SGTC_1726 st035556 14.5795 µM 0.266549853261893 0.377499176614862 no 1237 0.394907885128288 1925 5919439 SGTC_2845 9003024 42.97 µM 0.265739861503238 0.377842401956772 no 1238 0.395219780870364 1911 2990173 SGTC_1223 0764-0573 147 µM 0.265680441029509 0.377867584547721 no 1239 0.395242663986843 1832 1609797 SGTC_1920 st075728 45.7 µM 0.265104974082428 0.378111496159557 no 1240 0.395464297816133 1975 3400306 SGTC_1108 betulinic acid 729.144 nM 0.262689977044893 0.379135621204651 no 1241 0.396394771357943 1821 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2479 5617353 43.85 µM 0.261233845713449 0.379753531887846 no 1242 0.396956089469092 1907 2731746 SGTC_983 1491-0821 12.2 µM 0.261089879695323 0.379814640712758 no 1243 0.397011597959713 1946 46495113 SGTC_1540 guanosine 70.6 µM 0.260094419812172 0.380237262639984 no 1244 0.397395471094006 1952 6802 Guanosine is a purine nucleoside SGTC_2220 6782180 200 µM 0.25993717122996 0.38030403552947 no 1245 0.397456119007857 1943 833803 SGTC_1309 pyrazolanthrone 13.4 µM 0.25908984919626 0.380663897519159 no 1246 0.397782958315236 1938 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2841 9004761 38.96 µM 0.257418250151466 0.381374136739791 no 1247 0.398427957943325 1710 2991039 SGTC_2223 6903751 107.57 µM 0.257384132406559 0.381388637065898 no 1248 0.398441125439838 1915 5598863 SGTC_53 0973-0023 39.979 µM 0.256070733234554 0.381946969059715 no 1249 0.398948110104344 2019 674768 SGTC_2508 celastrol 40.54 µM 0.254942866577793 0.38242662642329 no 1250 0.399383613575963 1940 122724 Celastrol is a natural product and antioxidant. SGTC_2780 5215298 71.43 µM 0.25473960807506 0.382513087091946 no 1251 0.399462111173405 2018 2834131 SGTC_1275 0867-0008 21.1 µM 0.254449422898989 0.382636534164531 no 1252 0.399574186537335 1872 3422836 SGTC_1614 st002383 48.6 µM 0.254381579573371 0.38266539697311 no 1253 0.399600390191022 1948 1947235 SGTC_2476 5806916 10.51 µM 0.253879059917626 0.382879205840105 no 1254 0.399794496327037 1899 2870194 SGTC_391 gliotoxin 8.33 µM 0.253183423827219 0.383175239552328 no 1255 0.400063237589625 1904 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2179 6298986 200 µM 0.252910822814823 0.383291265794512 no 1256 0.400168562954664 1988 738374 SGTC_3113 9123498 49.47 µM 0.252538349450986 0.383449817289262 no 1257 0.400312487926079 1997 8897275 SGTC_795 0685-0265 78 µM 0.251996317771372 0.383680579882966 no 1258 0.400521954987176 1833 302754 SGTC_3108 9121785 49.47 µM 0.251789115630932 0.383768804273178 no 1259 0.400602035403624 1982 17140271 SGTC_1781 st038725 66.3 µM 0.250476539060534 0.384327824725826 no 1260 0.401109422838527 1798 4270275 YIL048W NEO1 SGTC_228 caffeine 993.056 µM 0.24886973451164 0.385012483109917 no 1261 0.40173077360376 1965 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1318 1280-3875 124 µM 0.24771329673131 0.385505462593165 no 1262 0.402178121577448 1891 373245 SGTC_1886 st057356 49.9 µM 0.247520617678081 0.385587618021278 no 1263 0.402252668611419 1807 24207747 SGTC_3026 9090633 49.47 µM 0.247136851616483 0.385751265344741 no 1264 0.402401157311541 1837 25236842 SGTC_800 3448-7362 155 µM 0.246949098893547 0.385831335151608 no 1265 0.402473808673968 1915 15991913 SGTC_507 nimesulide 162 µM 0.246922745388396 0.38584257436638 no 1266 0.402484006495079 1986 4495 A COX2 inhibitor. SGTC_2471 5466956 24.79 µM 0.244663528422312 0.38680643812079 no 1267 0.403358484979571 1909 724419 SGTC_633 0437-0093 97.7 µM 0.24446123751357 0.386892776909939 no 1268 0.40343680967038 1866 2831118 SGTC_2195 6536160 144.242 µM 0.243864681685265 0.387147422550925 no 1269 0.403667811702543 1838 3834386 SGTC_1348 1493-0373 93.8 µM 0.243462699917803 0.387319039767688 no 1270 0.403823488523268 1915 3010129 SGTC_56 0957-0365 83.25 µM 0.240831114680483 0.388443079430807 no 1271 0.404843006607537 1966 6752360 SGTC_2420 aureobasidin a 50 nM 0.240461740250596 0.388600926862775 no 1272 0.404986160032166 1996 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1322 1348-1070 12 µM 0.240220287021683 0.388704118752574 no 1273 0.405079743650309 1966 6758089 SGTC_1211 1056-0033 32.3 µM 0.240014739482091 0.388791971516242 no 1274 0.405159415044153 1999 6741922 SGTC_102 gallobenzophenone 83.616 µM 0.239363809292173 0.389070222111103 no 1275 0.405411745201277 1974 70837 SGTC_637 1181-0519 7.26 µM 0.238837558153175 0.389295218242239 no 1276 0.405615772833511 1906 6252091 YGR060W ERG25 SGTC_730 1436-0052 41.2 µM 0.235114682510579 0.39088797179928 no 1277 0.407059861544507 1929 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3339 9145883 14.936 µM 0.23313758875351 0.391734576123879 no 1278 0.40782728368992 1978 2030670 SGTC_405 ebelactone b 50 µM 0.232395814460152 0.392052341219259 no 1279 0.408115299762591 1881 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3076 9116187 49.47 µM 0.232118469984827 0.392171169982093 no 1280 0.408222999818201 2009 27241210 SGTC_2441 5730946 39.09 µM 0.230477377515677 0.392874504596984 no 1281 0.408860420236111 1958 1774275 SGTC_2080 5212524 12.4 µM 0.230231945180214 0.392979721403387 no 1282 0.408955769929782 2046 260183 SGTC_996 3970-0799 1.8 µM 0.230205428621202 0.392991089516538 no 1283 0.408966071852517 2011 6615648 YGL040C HEM2 SGTC_1013 4112-3890 241 µM 0.229455283072373 0.393312727824258 no 1284 0.409257536202898 1869 705171 SGTC_1612 st002233 45.4 µM 0.227914879742943 0.393973431379294 no 1285 0.409856207385335 2001 1035021 SGTC_687 k029-0044 34.9 µM 0.227206401625798 0.39427741155238 no 1286 0.410131625041948 2041 5829338 SGTC_2398 5228213 48.84 µM 0.226351507330591 0.394644298896309 no 1287 0.41046402034111 2066 80771 YMR134W ERG29 SGTC_682 0kpi-0099 17 µM 0.225079346141263 0.395190433884812 no 1288 0.410958774075706 1859 1714895 YML126C ERG13 SGTC_1695 st026914 34.495 µM 0.22445786245326 0.395457309918623 no 1289 0.411200525651649 1884 3289191 SGTC_1176 0848-0131 83.3 µM 0.224286784018334 0.395530782621377 no 1290 0.411267079550675 2039 6769040 SGTC_450 aminopyrene 156 nM 0.224176086875264 0.395578325473962 no 1291 0.411310144939436 1998 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2740 felodipine 17.08 µM 0.223990273485447 0.395658133181978 no 1292 0.411382435800569 2032 3333 L-type calcium channel blocker SGTC_3274 9138298 49.47 µM 0.223985531976555 0.395660169739179 no 1293 0.411384280528112 2020 17015756 SGTC_2839 9003951 25.97 µM 0.223831255053407 0.395726435806479 no 1294 0.411444304449427 2078 2990634 SGTC_1940 st075990 51.1 µM 0.22355762697378 0.395843973802447 no 1295 0.411550768957605 1962 1084979 SGTC_3216 9129716 49.47 µM 0.222999563969425 0.396083721263217 no 1296 0.411767922930818 1882 8056934 SGTC_1172 0370-0043 85 µM 0.222992395098522 0.396086801312253 no 1297 0.411770712664203 1949 376585 SGTC_1640 st009078 66.4 µM 0.222894089935968 0.396129038006987 no 1298 0.411808968119256 1995 690618 SGTC_2502 avocadyne acetate 18.59 µM 0.22252656625867 0.396286954909443 no 1299 0.411951997384435 1998 3952079 SGTC_2078 5212016 200 µM 0.221939275317215 0.39653933632385 no 1300 0.412180577795304 2063 1899708 SGTC_1141 3253-0389 52.6 µM 0.220634622170906 0.397100150745538 no 1301 0.412688470360138 2012 5402031 SGTC_1000 4048-0884 8.67 µM 0.21965369282362 0.397521950435035 no 1302 0.413070435802487 1931 13040088 SGTC_397 arbidol 50 µM 0.219475889737534 0.397598418620061 no 1303 0.413139679615393 2002 131410 A RNA synthesis inhibitor. SGTC_1977 st070720 65.3 µM 0.218867919025753 0.397859919707286 no 1304 0.413376468745737 1897 682188 SGTC_3027 9089541 49.47 µM 0.218728840532859 0.39791974676903 no 1305 0.413430640713318 1900 9943819 SGTC_3025 9087895 49.47 µM 0.218094940461377 0.398192460426552 no 1306 0.413677569726662 2034 17173641 SGTC_764 1951-2361 146 µM 0.217811411345275 0.398314455163406 no 1307 0.413788026526227 1829 5438930 SGTC_3165 9101544 49.47 µM 0.217575301282939 0.39841605437842 no 1308 0.413880015096028 1982 5002184 SGTC_818 4072-2707 53.5 µM 0.217240202215423 0.39856026082524 no 1309 0.414010577931547 1907 882871 SGTC_2963 9082507 9 µM 0.216865813381554 0.398721391602565 no 1310 0.414156460267292 1949 16459611 SGTC_234 nsc-17383 10.7 µM 0.215615460427621 0.399259647847466 no 1311 0.414643751789277 2007 408974 SGTC_2411 st077133 39.94 µM 0.215320549541386 0.399386630060379 no 1312 0.414758704572445 2056 1403142 YNL221C POP1 SGTC_3253 9135987 49.47 µM 0.212519127148428 0.400593390640063 no 1313 0.415851028632751 1982 4182430 SGTC_2769 toremifene 3.73 µM 0.209674814012486 0.401819598552978 no 1314 0.416960742038728 1952 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3272 9137413 49.47 µM 0.208239671481851 0.402438668755679 no 1315 0.417520917057164 2013 17614870 SGTC_932 2857-0803 154 µM 0.207223539312315 0.402877140664899 no 1316 0.417917642286488 2039 674898 SGTC_2549 cedrol 20.94 µM 0.207046940168738 0.402953357563035 no 1317 0.417986599857351 2037 6708665 A sedative which affects the nervous system. SGTC_3180 9109287 49.47 µM 0.205692504818578 0.403538029002652 no 1318 0.418515556830923 1952 18891271 SGTC_2524 avocatin b 10.57 µM 0.204677533762931 0.403976304730788 no 1319 0.418912037130516 2035 6710748 SGTC_1714 st033236 13.627 µM 0.203912373491922 0.404306789140656 no 1320 0.419210987791353 1999 2916566 SGTC_2827 7993847 71.43 µM 0.202573535228178 0.404885218011951 no 1321 0.419734188469085 1941 2985692 SGTC_1758 st042942 75.2445 µM 0.201555708854014 0.405325096746773 no 1322 0.420132036856428 2077 669317 SGTC_937 3122-0005 46.7 µM 0.201360341546677 0.405409543240454 no 1323 0.420208411458817 2068 759535 SGTC_779 1360-0071 233 µM 0.200948265521815 0.405587675374794 no 1324 0.420369513472837 2095 7566 SGTC_205 1486-1330 71.903 µM 0.200177635549411 0.405920855583334 no 1325 0.420670828711372 1961 4118834 SGTC_2006 4011487 200 µM 0.198186237017936 0.406782147509825 no 1326 0.421449677592937 2024 45595294 SGTC_1778 st046819 58.9 µM 0.195532636777652 0.407930546078187 no 1327 0.422487995145227 1921 671715 SGTC_1385 3091-4834 14.1 µM 0.195295633799343 0.408033152501111 no 1328 0.422580757493734 2014 4072814 SGTC_3124 9127567 49.47 µM 0.194299902664945 0.408464306256601 no 1329 0.422970530922162 2070 17592030 SGTC_1519 esterone 74 µM 0.193988804113374 0.408599035354649 no 1330 0.423092324203947 1847 698 A steroid. SGTC_1061 3448-9325 110 µM 0.193344575699323 0.408878069098561 no 1331 0.423344559256295 2100 723482 SGTC_3062 9077494 49.47 µM 0.193338041759092 0.408880899371715 no 1332 0.423347117654092 2024 16459633 SGTC_2464 5717415 7.67 µM 0.193090345242607 0.408988196295655 no 1333 0.42344410687765 1874 5285744 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.192659434398153 0.409174874063619 no 1334 0.423612847424426 2015 688761 SGTC_566 0958-0068 16.5 µM 0.192625981512311 0.4091893672742 no 1335 0.423625947839522 2037 6815365 SGTC_1097 itavastatin 7.23 µM 0.192370215666461 0.409300179999979 no 1336 0.423726110559815 1968 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2387 9077560 195.08 µM 0.191284990583006 0.409770443504635 no 1337 0.424151159875679 1930 5303272 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.19126566452175 0.409778819297331 no 1338 0.42415873010114 2013 2333 A French combination drug. SGTC_1456 k015-0012 13 µM 0.190488202029664 0.4101158007263 no 1339 0.424463293673596 2122 2989616 SGTC_1326 1431-2094 10.8 µM 0.18993722074486 0.410354656909082 no 1340 0.424679162698918 1893 616278 SGTC_3348 9149464 3.537 µM 0.189257618509248 0.410649317427974 no 1341 0.424945455254353 2079 1951442 SGTC_753 1322-0200 289 µM 0.189210234782179 0.410669863848239 no 1342 0.424964023178544 1985 5403907 SGTC_777 1315-0167 517 µM 0.189004420238915 0.410759111510449 no 1343 0.425044676191502 1918 4221767 SGTC_110 0850-0284 111.64 µM 0.188659539835913 0.410908672861187 no 1344 0.425179832290948 2087 3906265 SGTC_570 0987-0065 62.6 µM 0.188300025676571 0.411064594097117 no 1345 0.425320732613755 2088 3104428 SGTC_85 0868-0259 160.055 µM 0.187842206354012 0.411263170604385 no 1346 0.425500174374048 1988 83173 SGTC_1277 0873-0036 22 µM 0.186665835909591 0.411773518697489 no 1347 0.425961322109749 2045 5965735 SGTC_964 1287-0107 19.4 µM 0.186529430287394 0.411832705606403 no 1348 0.426014800897825 2069 51516812 YPR165W RHO1 SGTC_2361 9034121 116 µM 0.186208329875052 0.411972040191064 no 1349 0.426140695953466 1954 6496917 SGTC_1916 st067606 49.2 µM 0.186174449653311 0.411986742428708 no 1350 0.426153979939665 2037 19590279 SGTC_1345 1488-0192 31.4 µM 0.18597340367113 0.412073988371756 no 1351 0.426232809129768 2066 658348 SGTC_301 4119-0100 24.5 µM 0.185315675757574 0.412359446415468 no 1352 0.426490721748998 1956 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2560 caryophyllene 100 µM 0.184841169214692 0.41256541403546 no 1353 0.426676807920386 2063 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3116 9124943 49.47 µM 0.184713377854982 0.412620888162368 no 1354 0.426726926364056 1864 41905195 YPL160W CDC60 SGTC_3160 9100216 49.47 µM 0.181016447122571 0.414226474117285 no 1355 0.428177333168503 2116 17191039 SGTC_3181 9108277 49.47 µM 0.178844686530853 0.41517034564115 no 1356 0.429029828064779 1976 17097298 SGTC_2050 5263056 171 µM 0.178696429439087 0.415234797758062 no 1357 0.429088036476931 2105 763468 YGL055W OLE1 SGTC_1998 st075797 76.8 µM 0.177915585517505 0.415574293282433 no 1358 0.429394635325696 2102 24208315 SGTC_2596 sinensetin 100 µM 0.177695406361085 0.415670034236755 no 1359 0.429481096514592 1960 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_153 4077-0274 519.67 µM 0.177123070185144 0.415918927756281 no 1360 0.429705860517004 2106 3121976 SGTC_1438 4092-1045 4 µM 0.176422261450024 0.416223736442489 no 1361 0.429981108421732 2027 1351342 SGTC_1636 st007707 68.9 µM 0.174523140669168 0.417049989954788 no 1362 0.430727173100997 2072 403051 SGTC_2011 4012611 177 µM 0.172118933130215 0.418096517632178 no 1363 0.431672014200689 1975 2049887 SGTC_758 0868-0029 16 µM 0.168937071332742 0.419482441382546 no 1364 0.432923069774265 2139 762687 SGTC_516 3992-2719 87.3 µM 0.167696674068035 0.420022993006331 no 1365 0.433410956423024 1928 5350887 YDR037W KRS1 SGTC_1661 st013063 9.66 µM 0.165491253761641 0.420984463229913 no 1366 0.434278666703086 2028 721395 SGTC_2016 5121758 140 µM 0.164577227669834 0.421383078567667 no 1367 0.434638378231587 2108 2795203 SGTC_3207 9114163 49.47 µM 0.162324253589691 0.422365964969876 no 1368 0.435525258177258 2138 849233 SGTC_248 streptozotocin 5.23457 mM 0.16165711511791 0.422657105048116 no 1369 0.435787938709118 2135 5300 DNA alkylating agent. SGTC_669 0108-0021 26.2 µM 0.160107384357228 0.423333572346323 no 1370 0.436398242171155 2208 17201 SGTC_1355 1499-0035 1.68 µM 0.159455149632727 0.423618344644396 no 1371 0.43665514577364 2008 1548538 SGTC_2096 5468907 200 µM 0.159054717554149 0.423793197129025 no 1372 0.436812882058266 2126 759785 SGTC_445 e6 berbamine 66 µM 0.158867601436144 0.423874908311977 no 1373 0.436886593388087 2030 6610268 A calcium/calmodulin antagonist. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.157059300678268 0.424664737957579 no 1374 0.437599056389899 1998 75037 A free radical scavenger. SGTC_1269 0831-0796 3.05 µM 0.15695824708915 0.424708885102569 no 1375 0.437638877076866 2112 927758 SGTC_2037 5169046 200 µM 0.156603504935231 0.424863868301482 no 1376 0.43777867004635 2055 5718022 SGTC_853 0419-0306 21 µM 0.155979219213449 0.425136640504789 no 1377 0.438024700692758 1974 762713 SGTC_2888 9058547 12.99 µM 0.155708934405992 0.425254748489379 no 1378 0.438131227218396 2012 16476514 SGTC_3327 9140648 26.9345 µM 0.155552311671906 0.425323191942029 no 1379 0.438192958510416 2125 8029710 SGTC_884 0851-0618 334 µM 0.155424084767835 0.425379228216278 no 1380 0.43824349898837 2126 9642473 SGTC_686 1319-0111 510 µM 0.155125165830973 0.425509864247046 no 1381 0.438361321432559 2120 4562600 SGTC_1126 isoteolin 1.0172 µM 0.154818943636273 0.425643700487948 no 1382 0.438482028207752 2057 133323 SGTC_2400 5203494 178.7 µM 0.154800606189743 0.425651715250609 no 1383 0.438489256650758 2104 6777674 SGTC_446 go6976 132 µM 0.153541935939834 0.426201916523151 no 1384 0.438985461129546 2149 3501 A protein kinase C inhibitor. SGTC_3037 9091026 49.47 µM 0.153060035184546 0.426412607413133 no 1385 0.439175465875816 2120 25236398 YIL048W NEO1 SGTC_1012 4112-3522 18 µM 0.153038004181553 0.426422240047498 no 1386 0.439184152636914 2135 3112398 SGTC_690 glyoxal 20.3 µM 0.152439862260375 0.426683782907176 no 1387 0.43942000945398 2066 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_601 0986-0029 62.9 µM 0.152029807362727 0.426863101681982 no 1388 0.439581713014384 2050 24747981 SGTC_1316 1272-0050 65.9 µM 0.151872840042252 0.426931748170702 no 1389 0.439643615138678 2084 7340392 SGTC_2673 kobusone 100 µM 0.151562972451925 0.427067269000043 no 1390 0.439765819823044 2100 6710676 An epoxy ketone and protein crosslinker. SGTC_2918 7977171 22.06 µM 0.150771781371611 0.427413336042787 no 1391 0.440077873482986 2084 2236483 SGTC_1106 tegaserod maleate 11.7 µM 0.148334553224252 0.428479729778308 no 1392 0.441039373725513 2045 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_896 0964-0007 44.5 µM 0.147080920403112 0.42902845284358 no 1393 0.441534074699557 2177 6756758 SGTC_3054 9094397 49.47 µM 0.145575780024797 0.429687443517284 no 1394 0.442128144504291 2065 2598354 SGTC_1038 k292-0204 154 µM 0.143187082846076 0.430733680533182 no 1395 0.443071215548149 2096 4454212 SGTC_2382 9035899 200 µM 0.14274353037814 0.430928007979062 no 1396 0.443246368222478 2009 6462679 SGTC_1261 0712-0010 12.7 µM 0.142621720614078 0.430981377718239 no 1397 0.443294471139353 2132 2840123 SGTC_2851 9015922 71.43 µM 0.142513922166795 0.4310286095893 no 1398 0.443337041656553 2110 2996893 SGTC_2978 9011784 42.97 µM 0.142153363539632 0.431186595453188 no 1399 0.443479434052656 2166 2994934 SGTC_495 decylubiquinone 155 µM 0.141660521392729 0.431402561753028 no 1400 0.443674079872903 2005 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_33 0986-0033 35.816 µM 0.141351753653045 0.431537876028718 no 1401 0.443796033249443 2156 2848082 SGTC_1729 st035615 45.989 µM 0.1412851233434 0.431567077128834 no 1402 0.443822350788202 2003 17385451 SGTC_553 k007-0256 45.7 µM 0.14014242454521 0.432067929242413 no 1403 0.444273730690704 2043 6287000 SGTC_1195 1502-0147 41.1 µM 0.139803749128195 0.432216393835764 no 1404 0.444407525507215 2112 817940 SGTC_3050 9093513 49.47 µM 0.139518067944009 0.432341634876749 no 1405 0.44452038970734 2115 25236664 SGTC_1450 4112-4260 37.6 µM 0.139317737080313 0.432429462868354 no 1406 0.444599537200003 2161 1633175 SGTC_1009 4106-0057 9.87 µM 0.138620197966349 0.43273530028171 no 1407 0.444875140868346 2185 2928005 SGTC_1410 3909-8106 77.9 µM 0.138023693665676 0.432996870754254 no 1408 0.445110845962661 2146 1039210 SGTC_1484 3473-2379 286 µM 0.137693219167736 0.433141798315803 no 1409 0.445241439336543 2160 671917 SGTC_1837 st055472 66.5 µM 0.137614529346793 0.433176308579737 no 1410 0.445272536013993 2108 676091 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.136646756062587 0.433600777512818 no 1411 0.445655008558351 2090 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_304 1310-0298 97 µM 0.136127585361104 0.433828519295505 no 1412 0.445860210270955 2078 1550234 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.135638858714445 0.434042926426424 no 1413 0.446053392253696 2066 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_691 1548-0686 185 µM 0.134785297653508 0.43441743497523 no 1414 0.446390815263584 2040 46495133 SGTC_3064 1327-0027 10 µM 0.134566153014057 0.43451359641203 no 1415 0.446477452062518 2104 16000455 YPR107C YTH1 SGTC_766 1391-0721 126 µM 0.133689997199753 0.43489809531381 no 1416 0.446823857616657 2162 1020919 YIL115C NUP159 SGTC_746 1095-0025 46.6 µM 0.133494105177605 0.434984070498544 no 1417 0.446901312967111 2154 6749286 SGTC_2239 6685329 187.64 µM 0.13213651620788 0.435579987915942 no 1418 0.447438156686622 2032 805680 SGTC_1978 st071761 42 µM 0.131550145886351 0.435837422107909 no 1419 0.447670060261265 2028 5147680 SGTC_1761 st044296 37 µM 0.129812832531175 0.436600314081032 no 1420 0.448357254967707 2126 1826700 SGTC_132 0417-1715 25.805 µM 0.129273575432196 0.436837161671227 no 1421 0.448570589857541 2195 6769098 SGTC_454 lyso-paf C-16 6.67 µM 0.128802776613781 0.437043960155812 no 1422 0.448756854206918 2031 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2689 tacrolimus 100 µM 0.12794143733238 0.437422348113486 no 1423 0.44909765912278 2046 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1768 st044301 37.178 µM 0.127242756665188 0.437729321901808 no 1424 0.449374132732034 2088 3931349 SGTC_1030 k029-0042 36.7 µM 0.126460634528138 0.438073001163368 no 1425 0.449683653960466 2049 6080581 SGTC_2703 st077852 53.4 µM 0.125911722484697 0.438314231411273 no 1426 0.449900901664327 2091 6281836 SGTC_79 0052-0007 94.094 µM 0.125610342806618 0.438446688421307 no 1427 0.450020187715887 2163 2801472 SGTC_2137 5261020 140 µM 0.123611302795792 0.439325444616965 no 1428 0.45081152139544 2119 763655 SGTC_1086 cerivastatin 2.18 µM 0.123056642887414 0.439569320255967 no 1429 0.45103112211097 2203 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1806 st050005 60.3 µM 0.122780676180728 0.439690667226172 no 1430 0.451140388320694 2052 5194765 SGTC_832 4083-0019 164 µM 0.122707741241948 0.439722738831215 no 1431 0.451169266786523 2158 1990758 SGTC_2205 7238770 200 µM 0.122379810257589 0.439866944467987 no 1432 0.451299113697233 2207 279867 SGTC_938 3126-1755 342 µM 0.122110312103872 0.439985460599599 no 1433 0.451405827560338 2197 1777771 SGTC_1812 st052057 4.327 µM 0.121954258991785 0.44005408991558 no 1434 0.45146762191043 2151 3645418 SGTC_1949 st076024 69.1 µM 0.121216941933967 0.440378372851636 no 1435 0.451759602672159 2192 2921930 SGTC_821 1114-0266 29.2 µM 0.120890952898641 0.440521760408956 no 1436 0.451888704077074 2107 3123235 SGTC_2258 7960471 200 µM 0.119442267853989 0.441159064303262 no 1437 0.452462488027049 2036 2974708 SGTC_2931 9014674 55.67 µM 0.11928395109046 0.44122872010266 no 1438 0.452525198944111 2147 2996810 SGTC_3137 9097352 49.47 µM 0.119163261542872 0.44128182199843 no 1439 0.452573006125101 2150 44120435 SGTC_1457 k015-0032 57.3 µM 0.118728648139825 0.441473055213786 no 1440 0.452745169571655 2172 4302660 SGTC_1836 st055642 81 µM 0.118312659973323 0.441656105963684 no 1441 0.452909963323125 2089 8571 SGTC_1908 st060353 56.5 µM 0.117714768271253 0.441919223064208 no 1442 0.45314683237651 2215 4227716 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.116452817229835 0.442474659973747 no 1443 0.453646838998341 2167 23665772 A membrane-active detergent. SGTC_2820 7989630 71.43 µM 0.115156709372459 0.443045248434033 no 1444 0.454160455624096 2213 2984098 SGTC_1798 st045719 60.953 µM 0.114917554295452 0.443150545153309 no 1445 0.454255235479684 2200 3980186 SGTC_2132 5317594 122.667 µM 0.114420328950266 0.443369479535137 no 1446 0.454452299826249 2118 794577 SGTC_731 3966-0296 387 µM 0.114236996325658 0.443450207490979 no 1447 0.454524962517687 2181 660956 SGTC_1759 st043059 70 µM 0.112535014236075 0.444199763087782 no 1448 0.455199604356222 2094 669426 SGTC_1443 4112-3303 14 µM 0.111965459330615 0.44445064067908 no 1449 0.45542539688961 2167 704433 SGTC_2229 7354935 190 µM 0.110548403685727 0.44507492182749 no 1450 0.455987232242275 2199 318112 SGTC_2552 juarezic acid 87.02 µM 0.110512854732108 0.445090584609114 no 1451 0.456001327856181 2241 1549512 SGTC_3290 9121031 71.43 µM 0.108925071752983 0.445790244948101 no 1452 0.456630960287658 2119 17014854 SGTC_1936 st074407 74.3 µM 0.107803330195304 0.446284644941305 no 1453 0.457075850587139 2168 809813 SGTC_473 2-arachidonoylglycerol 10 µM 0.106898694806247 0.446683417733757 no 1454 0.457434674326298 2052 5282280 An endocannabinoid. SGTC_1017 4239-0030 168 µM 0.106744631043483 0.446751336044861 no 1455 0.457495787203041 2028 1149593 SGTC_3320 9137005 35.139 µM 0.104255354631732 0.447848937381309 no 1456 0.458483353308502 2060 4908713 SGTC_801 0866-0028 10.1 µM 0.104224529705845 0.447862531594941 no 1457 0.458495584044513 2189 6849771 SGTC_720 r052-1644 49.9 µM 0.103215201920191 0.448307692682047 no 1458 0.458896087481823 2162 1422863 YOR257W CDC31 SGTC_859 0439-0102 54.6 µM 0.103175076154732 0.448325391383476 no 1459 0.45891201033695 2248 610143 SGTC_3011 9081274 71.4286 µM 0.102499858992967 0.448623232054166 no 1460 0.459179962384084 2121 6625322 SGTC_2756 carbadox 75.1 µM 0.101637542311002 0.449003645068003 no 1461 0.459522189640892 2127 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_3250 9135583 49.47 µM 0.101137782979944 0.449224136544145 no 1462 0.459720542660818 2240 7699353 SGTC_558 k064-0027 21.3 µM 0.100697938953088 0.449418206644437 no 1463 0.459895123767978 2179 5088526 SGTC_1596 piperlongumine 63 µM 0.10055341554923 0.449481976600263 no 1464 0.4599524891007 2230 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3232 9132874 49.47 µM 0.0997939228133493 0.449817118942245 no 1465 0.460253966429501 2107 3784940 SGTC_1518 st038567 90.8 µM 0.0996583183609545 0.449876961067447 no 1466 0.460307796434541 2230 77966 SGTC_2877 9040724 71.43 µM 0.0996462694255454 0.44988227830717 no 1467 0.460312579456163 2237 6463895 SGTC_1675 st018485 24.5 µM 0.0982783785229412 0.450485991882499 no 1468 0.460855623247796 2099 3323024 SGTC_2608 thymoquinone 42.66 µM 0.0966508655546707 0.451204437852343 no 1469 0.461501830336699 2251 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2190 6049624 200 µM 0.0963780242385521 0.451324896071951 no 1470 0.461610172490629 2212 2265554 SGTC_36 0335-0881 14.2 µM 0.09583839212566 0.45156315442309 no 1471 0.461824462588787 2184 23828853 SGTC_1855 st056195 39.6 µM 0.0953126282987505 0.451795306431966 no 1472 0.462033256194163 2253 4028379 SGTC_3148 9097893 49.47 µM 0.0946092574652619 0.452105906914446 no 1473 0.462312598214438 2150 17174100 SGTC_2144 5628481 200 µM 0.0939618736109184 0.452391810102603 no 1474 0.462569721573866 2170 2818399 SGTC_2308 7584454 197.62 µM 0.0937332677813854 0.452492774867608 no 1475 0.462660521369368 2213 893577 SGTC_91 0417-1751 58.384 µM 0.093262370982661 0.45270075817339 no 1476 0.462847562678245 2245 6795624 SGTC_2168 5727979 200 µM 0.0916528730468271 0.453411730686275 no 1477 0.463486920789626 2232 695210 SGTC_939 1165-0479 45.3 µM 0.0914403622635863 0.453505615472288 no 1478 0.463571345809787 2261 1377347 SGTC_1050 3232-1156 69.3 µM 0.0911122297310731 0.453650585700928 no 1479 0.463701707571821 2141 700529 SGTC_2835 9006588 71.43 µM 0.0893206205585192 0.454442234020934 no 1480 0.464413553365848 2085 2345538 SGTC_307 1501-1223 22.3 µM 0.0888971782349346 0.454629364672979 no 1481 0.464581813058642 2186 2830329 SGTC_1730 st033808 45.1 µM 0.0877083487801078 0.455154794355889 no 1482 0.46505424191637 2056 1045166 SGTC_1900 st060200 72.8 µM 0.087098260769737 0.455424466876392 no 1483 0.46529670391917 2220 688945 SGTC_561 1550-0330 72.9 µM 0.0860812389105765 0.455874058842611 no 1484 0.465700918719728 2172 6812934 SGTC_870 0573-2213 57.6 µM 0.0857885380132317 0.456003462794636 no 1485 0.465817259113154 2252 3916321 SGTC_106 0092-0003 11.579 µM 0.0847873388032805 0.456446131195308 no 1486 0.466215229731604 2259 1072148 SGTC_850 0388-0143 75.9 µM 0.0845865390728139 0.456534918949444 no 1487 0.46629505048768 2131 67273 SGTC_1696 st025591 34.7925 µM 0.0837184916507769 0.456918768983949 no 1488 0.466640127273393 2266 2787147 SGTC_2774 tamoxifen 10.92 µM 0.0831607225591871 0.457165435368699 no 1489 0.466861871687824 2249 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2999 9069765 71.4286 µM 0.0829179027869047 0.457272824529068 no 1490 0.466958409347791 2223 2097066 SGTC_2485 5633444 17.78 µM 0.0825843443806204 0.457420348726147 no 1491 0.467091025060698 2150 5724239 SGTC_1466 k213-0079 57.5 µM 0.0797648504628484 0.458667569866084 no 1492 0.468212140241614 2255 3657981 SGTC_2396 5342950 42.78 µM 0.0778968906808001 0.459494098716243 no 1493 0.468955036387222 2181 1886677 SGTC_2844 9010103 25.97 µM 0.0778468955168113 0.459516222837827 no 1494 0.468974921189421 2160 2480525 SGTC_2129 girgensonine 121.053 µM 0.0777933606831086 0.459539913491571 no 1495 0.468996213926232 2209 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2342 7990637 118.86 µM 0.0764081781858962 0.460152945003671 no 1496 0.469547181688566 2199 2033102 YER133W GLC7 SGTC_975 1335-0046 28.5 µM 0.0763402225794152 0.46018302213893 no 1497 0.469574213100736 2187 16486740 SGTC_2477 5967686 25.23 µM 0.0745100794577596 0.460993128185358 no 1498 0.470302260607535 2240 776118 SGTC_2053 5265679 138 µM 0.0743756124350573 0.461052655938553 no 1499 0.470355756751827 2258 764595 SGTC_31 0508-1974 57.237 µM 0.0739381157298597 0.461246339166337 no 1500 0.470529813435328 2251 6810525 SGTC_22 0964-0034 14.468 µM 0.0738905052025759 0.461267417276172 no 1501 0.470548755473657 2227 138402 SGTC_199 4063-0024 41.6 µM 0.0736768175508925 0.461362022310242 no 1502 0.470633772778979 2252 306215 SGTC_1657 st012939 43.4 µM 0.0735791096056638 0.461405280866118 no 1503 0.470672647096178 2257 24207257 SGTC_1437 4092-1038 11.6 µM 0.0734788049872262 0.461449689530556 no 1504 0.470712554822717 2261 3977136 SGTC_3249 9135183 49.47 µM 0.0733214160984134 0.461519372538371 no 1505 0.470775174991993 2237 4902779 SGTC_183 3914-0051 30.55 µM 0.0732912745875906 0.461532717650431 no 1506 0.470787167449072 2266 1596232 SGTC_722 3534-0461 190 µM 0.0729009713952164 0.461705527753206 no 1507 0.470942460470383 2202 658262 SGTC_2925 9010536 32.5 µM 0.0709368134753088 0.462575284685529 no 1508 0.471724022122568 2202 2994177 SGTC_1134 3477-0009 42.5 µM 0.0707783992217839 0.462645440614035 no 1509 0.471787061812394 2291 3973534 SGTC_2199 6590217 200 µM 0.069431090877609 0.463242161372099 no 1510 0.472323240842071 2242 703109 SGTC_1023 4482-3888 16 µM 0.0692549976543715 0.463320158925896 no 1511 0.472393323177335 2281 3303168 SGTC_198 3454-2873 16.191 µM 0.0689656692790915 0.46344831516036 no 1512 0.47250847317822 2230 710957 SGTC_665 3914-0008 307 µM 0.0682879195994442 0.463748535063365 no 1513 0.472778220222007 2246 1069549 SGTC_1247 0448-0043 5.84 µM 0.0670000939530866 0.464319054474898 no 1514 0.473290814203102 2215 3089013 YGL099W LSG1 SGTC_367 0335-0881 7.1 µM 0.066056496288069 0.464737124151107 no 1515 0.473666423048017 2249 23828853 SGTC_584 0986-0246 15.4 µM 0.0660171680910011 0.464754549721021 no 1516 0.473682078555633 2299 53315 YDR232W HEM1 SGTC_48 0382-0018 55 µM 0.0650715388885191 0.465173560161981 no 1517 0.474058520533918 2300 762596 SGTC_1912 st060209 90.8 µM 0.0649713030222648 0.465217977173067 no 1518 0.47409842441722 2214 688787 SGTC_3325 9138760 55.175 µM 0.0649589537362109 0.465223449479564 no 1519 0.474103340684133 2255 43844959 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0643671599809696 0.465485697172888 no 1520 0.474338939160463 2139 688788 SGTC_194 1486-1323 56.904 µM 0.063769267349803 0.465750662746286 no 1521 0.474576974768302 2225 5178754 SGTC_1604 st002052 72.4 µM 0.063640144140967 0.465807887735632 no 1522 0.474628383054889 2223 6254834 YHR062C RPP1 SGTC_3131 9127911 49.47 µM 0.0635991316410072 0.465826063855976 no 1523 0.474644711597141 2238 45595681 SGTC_2128 5255449 168.493 µM 0.0630892398275019 0.46605204614452 no 1524 0.474847721302167 2277 736008 SGTC_501 nsc-95397 161 µM 0.0608107503345945 0.467061997529294 no 1525 0.475754964319598 2263 262093 SGTC_142 0335-0849 62.6745 µM 0.0606594606930293 0.467129064968433 no 1526 0.475815208937857 2289 3889043 YPR107C YTH1 SGTC_2149 5554786 194.827 µM 0.0603263173597035 0.46727675232728 no 1527 0.475947870945159 2245 745063 YPR165W RHO1 SGTC_2643 anethole 100 µM 0.0589037938905424 0.467907428424961 no 1528 0.476514368106592 2288 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1116 jasmonic acid  1.58368 µM 0.0587144194879632 0.467991393719299 no 1529 0.476589787031075 2292 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1453 4237-0541 195 µM 0.0586257229502601 0.468030720701029 no 1530 0.47662511098208 2301 739892 SGTC_1158 4092-0494 91.8 µM 0.0569017043837305 0.46879519137438 no 1531 0.477311748306429 2255 1148199 SGTC_1942 st076330 65.2 µM 0.0561254250223463 0.469139449772367 no 1532 0.477620944809625 2262 24208414 SGTC_2123 5259487 200 µM 0.0559249040466944 0.469228379031889 no 1533 0.477700815656304 2290 2173474 SGTC_839 0122-0028 230 µM 0.0555402440580968 0.469398976590234 no 1534 0.477854034645245 2236 759448 SGTC_2 0422-0095 29 µM 0.054069080700831 0.470051492363827 no 1535 0.478440063112692 2234 6790840 SGTC_2472 5377652 49.4 µM 0.0537229091971818 0.47020504408047 no 1536 0.478577965128173 2194 1610903 SGTC_2140 5586273 200 µM 0.0535511392539996 0.470281237930028 no 1537 0.478646392919103 2318 854421 SGTC_294 k038-0071 157 µM 0.0534146872952383 0.470341766175291 no 1538 0.478700751574685 2255 24152826 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0530970066544275 0.470482687667694 no 1539 0.478827308217086 2312 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1381 2324-0066 62.1 µM 0.0526790087955536 0.470668114989352 no 1540 0.478993832176434 2264 10885928 SGTC_2185 6113692 200 µM 0.0518554543543547 0.47103346915042 no 1541 0.47932193438254 2266 874150 SGTC_3107 9121808 49.47 µM 0.0514433577579564 0.471216297087633 no 1542 0.479486117998052 2310 662681 SGTC_756 0508-1999 28.3 µM 0.0510279474192054 0.471400601316682 no 1543 0.479651625366037 2270 6753853 SGTC_1824 st053723 68.6 µM 0.0509444072181435 0.47143766616254 no 1544 0.479684909793278 2259 675225 SGTC_11 0438-0307 1.3 µM 0.0506375154922268 0.471573829010879 no 1545 0.479807184059221 2327 4011476 SGTC_3075 9116269 49.47 µM 0.0506211371035944 0.471581095928053 no 1546 0.47981370972186 2261 17015205 YNL244C SUI1 SGTC_296 1222-0039 74.9 µM 0.0503150344978179 0.471716912143066 no 1547 0.47993567157392 2269 5984176 SGTC_2800 7887935 81.82 µM 0.0491843238664502 0.472218631260048 no 1548 0.480386201944356 2253 2961002 SGTC_597 k018-0003 82.8 µM 0.0485802333769752 0.472486696515381 no 1549 0.480626911421378 2302 6786234 SGTC_3153 9100258 49.47 µM 0.0480189480242006 0.47273577815585 no 1550 0.480850570842836 2281 25236848 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0474401642275592 0.47299263624646 no 1551 0.481081209307678 2307 23847180 SGTC_3069 9117009 49.47 µM 0.0466731773301743 0.473333034154746 no 1552 0.481386854215289 2327 41904981 SGTC_587 k089-0003 57 µM 0.0458640051182523 0.473692175512219 no 1553 0.481709321862612 2330 9659696 SGTC_2823 7987624 58.44 µM 0.0455843100009902 0.473816319815104 no 1554 0.481820787488709 2276 2239440 SGTC_1927 st060202 13.8 µM 0.0452363400843427 0.473970771832723 no 1555 0.481959464343726 2343 688887 SGTC_3255 9139072 49.47 µM 0.0452011015011191 0.473986413260533 no 1556 0.481973508139229 2243 17646060 SGTC_593 1203-0218 61.7 µM 0.0451126578312329 0.474025671124321 no 1557 0.48200875610241 2343 3666956 SGTC_1153 4055-0057 267 µM 0.044358206831498 0.474360562677332 no 1558 0.482309437476352 2304 882706 SGTC_1985 st071382 65.5 µM 0.0441221137165846 0.474465365250888 no 1559 0.482403532875344 2337 6123237 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0437236259958252 0.474642259372137 no 1560 0.482562353200858 2312 4620898 SGTC_390 dec-rvkr-cmk 16.7 µM 0.0424384420236365 0.475212803909894 no 1561 0.48307459181845 2296 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2155 5570423 76 µM 0.0414894876026602 0.475634115399266 no 1562 0.483452836658581 2274 797402 SGTC_1862 st057513 3.81 µM 0.0412389186422596 0.475745366174226 no 1563 0.483552713729521 2332 5393163 SGTC_2893 9048488 25.97 µM 0.0410755772490564 0.475817889569702 no 1564 0.483617822349612 2304 6467338 SGTC_3133 9127736 49.47 µM 0.0392677458013604 0.476620617669498 no 1565 0.484338460947497 2347 27243420 SGTC_2581 avocatin a 64 µM 0.0389569841447545 0.476758614248448 no 1566 0.484462342119409 2306 6710728 A skin care supplement. SGTC_2885 9057732 51.95 µM 0.0389214176738637 0.476774408045845 no 1567 0.484476520335396 2293 6471414 SGTC_3042 9091578 49.47 µM 0.0384802307071856 0.47697032642052 no 1568 0.484652396709458 2318 25236497 SGTC_1656 st012921 11 µM 0.0384314458152085 0.476991990723063 no 1569 0.484671844679862 2330 6732821 SGTC_146 3448-8650 53.125 µM 0.0380446895817166 0.477163743100846 no 1570 0.48482602533383 2237 2891488 YIL048W NEO1 SGTC_928 2764-0428 58.7 µM 0.0377062297178549 0.477314051299889 no 1571 0.484960954467058 2260 662578 SGTC_246 cycloheximide 667 µM 0.0367824750092657 0.477724302142915 no 1572 0.485329223754495 2300 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_650 1328-0195 38 µM 0.0363912559444959 0.477898054488901 no 1573 0.485485193154175 2337 2780821 SGTC_3353 9151644 39.2805 µM 0.0357858714564395 0.478166932514895 no 1574 0.485726549398185 2306 4909158 SGTC_2739 tacrine 100.86 µM 0.0337430705431968 0.479074303380706 no 1575 0.486541016592979 2308 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_595 3909-8003 73.7 µM 0.0335703844454188 0.479151012091681 no 1576 0.486609869370126 2310 699517 SGTC_1202 1988-0068 29.6 µM 0.033436704068849 0.47921039464245 no 1577 0.486663170201205 2315 2850480 SGTC_2108 5365811 200 µM 0.0333310457670804 0.479257329752042 no 1578 0.486705298282977 2324 780283 SGTC_2536 dehydroabietamide 32.04 µM 0.0325992678565735 0.479582405077317 no 1579 0.486997076843648 2347 3983547 SGTC_2697 mebhydrolin 72.4 µM 0.0315543635837761 0.480046602997626 no 1580 0.487413718916829 2336 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2298 7976326 193.81 µM 0.030125131981601 0.480681581736337 no 1581 0.487983628700727 2321 2235818 SGTC_1253 0550-0034 176 µM 0.0298803635924986 0.480790332349824 no 1582 0.488081233219835 2303 5969915 SGTC_3282 9108498 15.4605 µM 0.0292910299785551 0.48105217916795 no 1583 0.4883162404373 2320 16459645 SGTC_2084 5306078 60.6385 µM 0.0291857555033191 0.481098954533934 no 1584 0.488358220928446 2313 679340 SGTC_2768 sulfasalazine 50.2 µM 0.0291083442982839 0.481133349907752 no 1585 0.488389090415724 2355 5384001 An antioxidant and salicylic acid derivative. SGTC_2091 4-phenylthiadiazole 200 µM 0.0286603984899354 0.48133238409651 no 1586 0.488567720404849 2341 270010 SGTC_2497 7-hydroxyflavone 100 µM 0.0274107912913581 0.481887642117908 no 1587 0.489066045638891 2346 5281894 SGTC_2868 9035608 32.47 µM 0.0272339322300552 0.481966231606331 no 1588 0.4891365758653 2357 6462614 SGTC_2671 danthron 100 µM 0.0269518653475482 0.482091572926577 no 1589 0.489249062978498 2334 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_371 0195-0006 7.36 µM 0.0269384083611694 0.482097552816633 no 1590 0.489254429590789 2325 3928593 SGTC_662 k832-1615 104 µM 0.0266639734621479 0.482219504513367 no 1591 0.489363873960668 2328 5878478 SGTC_2996 9066192 71.4286 µM 0.0257395144598472 0.482630322108597 no 1592 0.489732553153417 2331 6472854 SGTC_590 k048-0076 22.4 µM 0.0256006178356498 0.48269204757198 no 1593 0.489787946635532 2360 6832814 SGTC_529 4076-0302 30.3 µM 0.0253829162178045 0.48278879469724 no 1594 0.489874768800816 2312 5816522 SGTC_2570 licareol 100 µM 0.0250825138888389 0.482922295881362 no 1595 0.489994573845118 2307 443158 SGTC_1045 1348-1485 165 µM 0.0248929608771833 0.483006535733519 no 1596 0.490070170951122 2359 6810614 SGTC_320 4092-0846 5.34 µM 0.024480167327313 0.48318998923764 no 1597 0.490234801577301 2356 1359356 SGTC_1506 4226-2149 212 µM 0.0238204558268992 0.48348318526738 no 1598 0.490497911643889 2286 991114 SGTC_1534 6-azauridine 81.6 µM 0.0235451870815319 0.483605525792657 no 1599 0.490607697192184 2373 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1767 st044992 70.3 µM 0.0230956201731851 0.483805334760476 no 1600 0.490786999675613 2348 9600693 SGTC_1616 st002734 56.1 µM 0.0225396612724253 0.484052435021163 no 1601 0.49100873745362 2311 4026101 SGTC_2645 abamectin 100 µM 0.0219079791959907 0.484333198464413 no 1602 0.491260679912849 2353 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1224 0823-0416 294 µM 0.0216060950361493 0.48446737953045 no 1603 0.491381085765984 2361 3598164 SGTC_1772 st048439 82.2 µM 0.0210664840649589 0.484707229462495 no 1604 0.491596310400039 2332 2927068 YDL195W SEC31 SGTC_1404 3909-7820 48.3 µM 0.0205796542811697 0.484923623605896 no 1605 0.491790485280536 2365 23741373 SGTC_2796 7949634 45.45 µM 0.0205645463198753 0.484930339113437 no 1606 0.491796511209811 2368 2971588 SGTC_559 1550-0661 158 µM 0.0200219921541642 0.485171507931473 no 1607 0.492012914439439 2343 5830875 SGTC_3044 9093193 49.47 µM 0.0191526582464092 0.485557943719173 no 1608 0.492359661956582 2351 25236277 SGTC_323 4013-0906 34.3 µM 0.0191023354703819 0.485580313588187 no 1609 0.492379734167448 2368 2910086 SGTC_3126 9127922 49.47 µM 0.0185110772802257 0.48584314762463 no 1610 0.492615570344303 2337 45595682 SGTC_2884 9058502 51.95 µM 0.017331152202106 0.486367682046945 no 1611 0.493086216734413 2354 6471554 SGTC_3313 9133968 57.047 µM 0.017283129757488 0.486389030878611 no 1612 0.493105372048899 2376 1494643 SGTC_2328 6201408 200 µM 0.01688753722455 0.486564896756877 no 1613 0.493263167602448 2361 2890418 SGTC_317 4495-0002 170 µM 0.0166639290543574 0.486664305876331 no 1614 0.493352361803963 2336 15991618 SGTC_1157 4092-0394 27.6 µM 0.0165159591397378 0.486730089075884 no 1615 0.493411385136134 2372 3659885 SGTC_1821 st053465 65.6 µM 0.0159026528694981 0.487002751363823 no 1616 0.493656026793453 2358 675086 SGTC_1909 st060837 51.5 µM 0.0157114609865903 0.487087752258647 no 1617 0.493732291790601 2356 678937 SGTC_138 0850-0259 40.9225 µM 0.0153056697089814 0.487268162597676 no 1618 0.493894159620107 2381 6813004 SGTC_955 1216-0110 33 µM 0.0142786343825431 0.487724782766379 no 1619 0.494303842593926 2372 3619719 SGTC_2285 7945142 200 µM 0.0141794067708965 0.487768900249901 no 1620 0.494343424676383 2368 2970608 SGTC_644 1498-1197 63.3 µM 0.0134975096893808 0.488072081810336 no 1621 0.494615436201064 2358 6741615 SGTC_1206 3978-0017 132 µM 0.0128355195818772 0.488366419030626 no 1622 0.49487950914888 2338 3873677 SGTC_1846 st056244 14.8 µM 0.0113994287193286 0.489004962213575 no 1623 0.495452384403133 2340 5393182 SGTC_359 0081-0058 15.9 µM 0.0112207278584166 0.489084421737371 no 1624 0.495523671172428 2380 3494159 SGTC_2249 haloperidol 116.36 µM 0.0108603848730649 0.489244649935237 no 1625 0.495667418462728 2389 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3060 1327-0027 12.5 µM 0.0108534382873146 0.489247738784295 no 1626 0.495670189586164 2380 16000455 YPR107C YTH1 SGTC_1588 farnesol 29.9 µM 0.01033145407647 0.489479844630383 no 1627 0.495878419473192 2387 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2957 9076800 11.52 µM 0.0101551153214671 0.489558256347376 no 1628 0.495948764767563 2381 16459615 SGTC_3072 9116419 49.47 µM 0.00945628879424042 0.489869004160741 no 1629 0.496227542807441 2390 17170162 SGTC_135 0933-0004 26.348 µM 0.00894707345243943 0.490095441283488 no 1630 0.496430681734756 2373 21230617 YGL099W LSG1 SGTC_1149 3909-7961 23.3 µM 0.00857913477677989 0.490259057698737 no 1631 0.496577462392346 2373 735261 SGTC_2357 9067248 200 µM 0.00781797700981466 0.490597537495417 no 1632 0.496881110195099 2364 9150235 SGTC_342 k048-0088 23.3 µM 0.0059895179098467 0.491410663495959 no 1633 0.497610542353246 2396 6820570 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.00554918569037768 0.491606487160546 no 1634 0.497786206568043 2390 6708739 YPR165W RHO1 SGTC_1689 st020265 53.493 µM 0.00545933355147687 0.49164644627423 no 1635 0.497822051842219 2397 5758320 YPR016C TIF6 SGTC_147 4466-0538 29.23 µM 0.00545183994345182 0.491649778841261 no 1636 0.497825041314804 2373 6742687 YHR072W ERG7 SGTC_2612 dictamnine 15.46 µM 0.00499631158992592 0.491852363084406 no 1637 0.498006768353606 2385 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2458 5808907 16.39 µM 0.0048226420269607 0.491929598606754 no 1638 0.498076051650033 2398 2731747 SGTC_16 erodoxin 22.806 µM 0.00429097344180815 0.492166047784807 no 1639 0.498288154523197 2395 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3032 9089427 49.47 µM 0.00413364746414183 0.49223601595998 no 1640 0.498350917950603 2379 17173707 SGTC_2087 5276107 200 µM 0.00292851957718516 0.49277198479325 no 1641 0.498831691391624 2398 144405 SGTC_816 0325-0417 81.3 µM 0.00289533195661349 0.492786744851759 no 1642 0.498844931280523 2397 68101 SGTC_476 mead acid 10 µM 0.00179318373309059 0.493276926253097 no 1643 0.499284623575725 2404 5312531 An omega 9 fatty acid. SGTC_3212 9128307 49.47 µM 0.00144499167977254 0.49343178712339 no 1644 0.499423531924721 2400 27243542 SGTC_1273 0849-0096 14.1 µM 0.00125733080785078 0.493515251031108 no 1645 0.499498397712459 2401 5286025 SGTC_995 3931-2021 34.6 µM 0.0010863752929128 0.493591285324066 no 1646 0.499566599048524 2398 730143 SGTC_2894 9048625 32.47 µM 0.000321944741636138 0.493931276793451 no 1647 0.499871562632827 2403 4092861 SGTC_3254 9136651 49.47 µM 0.000316409417849041 0.493933738724599 no 1648 0.499873770907409 2405 16454030 SGTC_1906 st060206 94.7 µM 0.00016993898906053 0.493998884068926 no 1649 0.499932204152501 2402 5133468 SGTC_645 0845-0943 5.41 µM 7.21870349701911e-05 0.494042361088957 no 1650 0.499971201539679 2404 1885106 SGTC_1676 st018489 23.4 µM 0 0.494074467675858 no 1651 0.5 2406 3696235 SGTC_1848 st056003 16.4 µM 0 0.494074467675858 no 1652 0.5 2401 146492 SGTC_2513 baicalein 25.65 µM -0.00121648245749272 0.49461552750206 no 1653 0.499514693834035 2409 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2974 9094440 9.66 µM -0.00503402381075329 0.496313530532693 no 1654 0.497991723543435 2442 25236134 SGTC_931 2812-0076 566 µM -0.00548131654926263 0.496512486694417 no 1655 0.497813282026169 2417 3450959 SGTC_489 paxilline 115 µM -0.00554505740528159 0.496540838749049 no 1656 0.497787853490175 2422 105008 A toxic potassium channel blocker. SGTC_2940 9060638 45.86 µM -0.00690480358140301 0.497145660378738 no 1657 0.497245403801693 2424 4027022 SGTC_1694 st024011 44.9 µM -0.00724943641803994 0.497298955816785 no 1658 0.497107918635683 2415 2787533 SGTC_3338 9144300 39.5675 µM -0.00735133676252318 0.497344281981222 no 1659 0.497067267363181 2419 4901274 SGTC_34 0469-0683 81.75 µM -0.00737060992393211 0.497352854855851 no 1660 0.497059578692522 2424 3690923 SGTC_2636 apigenin dimethyl ether 100 µM -0.00822735709653425 0.497733944840465 no 1661 0.496717796426675 2434 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1945 st075991 56.6 µM -0.00833379225747164 0.497781288450028 no 1662 0.496675336396598 2431 1084980 SGTC_993 3909-8757 62.7 µM -0.00857350366342899 0.497887915011994 no 1663 0.49657970879893 2425 4288324 YLR208W SEC13 SGTC_1983 st071813 46.9 µM -0.0093343118853518 0.498226332766838 no 1664 0.49627620240592 2448 11838595 SGTC_914 3820-6779 408 µM -0.0101748468700882 0.498600215534794 no 1665 0.495940893425231 2429 2893481 SGTC_1053 3366-3204 134 µM -0.0103947412338697 0.49869802811444 no 1666 0.495853172906002 2427 3632071 YPR165W RHO1 SGTC_713 1488-1073 324 µM -0.0105215519325349 0.498754435606006 no 1667 0.49580258552325 2422 3312542 SGTC_1090 efavirenz 20.7 µM -0.0110857201959211 0.499005387246331 no 1668 0.495577528087281 2433 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2417 cerulenin 830 nM -0.0112361778833666 0.499072313455639 no 1669 0.495517507892782 2425 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1058 3448-5425 97.3 µM -0.0113908316947024 0.499141106201392 no 1670 0.495455813897076 2427 7279705 SGTC_2975 9084847 53.72 µM -0.0122559296392158 0.499525917453968 no 1671 0.495110713883093 2465 27211724 SGTC_65 0798-0905 34.986 µM -0.0123828818099739 0.499582388127232 no 1672 0.495060071137736 2433 3602145 SGTC_1392 3455-1037 33.9 µM -0.0127582247123138 0.49974934763599 no 1673 0.494910342815636 2442 981132 SGTC_2443 5493264 126.67 µM -0.012913105263335 0.49981824140215 no 1674 0.494848559505226 2438 5340055 SGTC_3200 9114385 49.47 µM -0.0130030800132671 0.499858263856533 no 1675 0.494812667786776 2443 17018030 YLR208W SEC13 SGTC_1965 Pectolinarigenin 58.4 µM -0.0133217179747864 0.5 no 1676 0.494685560643377 2425 5320438 An anti-inflammatory. SGTC_1523 st012844 44.7 µM -0.0134893713338134 0.499925424639312 no 1677 0.494618682639635 2466 4274103 SGTC_2534 helenine 20.12 µM -0.0145722389562015 0.499443744974132 no 1678 0.494186723502674 2437 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_749 1000-0129 128 µM -0.014710430856624 0.499382274689418 no 1679 0.49413159881965 2442 708470 SGTC_2353 9059630 146.67 µM -0.0155983933117898 0.498987293162174 no 1680 0.493777393739543 2433 4779114 SGTC_1968 st069590 43.6 µM -0.0162820052336762 0.498683211050582 no 1681 0.493504706691546 2442 6384066 SGTC_1239 0337-0584 35.4 µM -0.0171690546774541 0.498288637664923 no 1682 0.493150874669755 2439 914301 YML130C ERO1 SGTC_505 gw-5074 63.9 µM -0.0175174443023942 0.49813366897901 no 1683 0.493011908220328 2493 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1024 4507-0395 26 µM -0.01764900977027 0.498075146849972 no 1684 0.492959429305667 2519 4201836 SGTC_410 α-linolenic acid 100 µM -0.0194170490264523 0.49728870320467 no 1685 0.492254204908038 2517 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2738 aclarubicin 5.55 µM -0.0198409058250707 0.497100168408405 no 1686 0.492085143084122 2451 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_375 3970-0961 9.27 µM -0.0200847193527444 0.49699171854824 no 1687 0.491987894938939 2452 2898222 SGTC_2407 paclitaxel 400 µM -0.0210546161900671 0.496560304338007 no 1688 0.49160104394722 2608 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_575 k072-0246 11.9 µM -0.0213290975370054 0.49643821458383 no 1689 0.491491566318765 2443 6796779 SGTC_3106 9121286 49.47 µM -0.0213317481878586 0.496437035571583 no 1690 0.491490509102607 2547 15943471 SGTC_82 0054-0107 293.755 µM -0.0220437651216917 0.496120330861501 no 1691 0.491206522245048 2521 3104697 SGTC_1603 st002045 67.8 µM -0.0229902290820597 0.495699348072309 no 1692 0.490829033476861 2449 5887985 SGTC_1258 0671-0043 57.1 µM -0.0232885657996473 0.495566650251644 no 1693 0.490710046205904 2467 4298767 SGTC_2015 5119600 184 µM -0.0240644783553226 0.495221532795789 no 1694 0.490400588638974 2463 2828786 SGTC_958 1222-0007 33 µM -0.0247137619115168 0.494932741277724 no 1695 0.490141639007838 2469 7312461 SGTC_2391 6285546 200 µM -0.0254076304643338 0.494624121965873 no 1696 0.489864912421747 2451 846083 SGTC_3016 9080866 49.47 µM -0.0259320347302563 0.494390879215932 no 1697 0.489655774306563 2449 17066299 SGTC_1123 mangostin 811.285 nM -0.0260495593733746 0.494338607264158 no 1698 0.489608904590885 2494 5281650 An antioxidant. SGTC_742 0kpi-0133 140 µM -0.0263540517930059 0.494203177287525 no 1699 0.489487471382308 2467 2728852 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0274099905312761 0.493733529627666 no 1700 0.489066364975958 2474 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3065 9113888 49.47 µM -0.0283349993617217 0.493322122503542 no 1701 0.488697483172433 2507 16648368 SGTC_3091 9116372 49.47 µM -0.0284195940722226 0.493284498489992 no 1702 0.488663748351297 2557 17169793 SGTC_1407 3909-7909 12.3 µM -0.0286722183397603 0.493172142662816 no 1703 0.48856300690408 2465 4411780 SGTC_3093 9117344 49.47 µM -0.0291919210168426 0.49294100417432 no 1704 0.488355762292009 2574 24824913 SGTC_69 0096-0274 206.684 µM -0.02958054819572 0.492768163240486 no 1705 0.488200789407942 2665 6741392 SGTC_1830 st055982 50.3 µM -0.0309126977057891 0.492175703690306 no 1706 0.487669581729255 2449 455313 An antimicrobial agent. SGTC_1085 doxorubicin 7.67 µM -0.0319488624265409 0.491714892143674 no 1707 0.487256415963549 2460 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_440 fluspirilene 35.1 µM -0.0325377055466967 0.491453021961385 no 1708 0.487021623630014 2669 3396 An atypical antipsychotic. SGTC_1283 0922-0125 16.4 µM -0.0332697863917498 0.49112745627936 no 1709 0.486729723691225 2487 3360884 SGTC_2991 9074669 71.4286 µM -0.0341566626203276 0.490733059055466 no 1710 0.486376112288945 2498 17333109 SGTC_2934 9036370 36.88 µM -0.0346598384311978 0.490509298866804 no 1711 0.486175492980166 2506 6462800 SGTC_1526 st051518 75 µM -0.0347741890779648 0.490458448024145 no 1712 0.486129901155937 2527 673993 SGTC_45 0kpi-0036 14.9 µM -0.0351739263636361 0.490280689188258 no 1713 0.485970526554791 2489 2795021 SGTC_1700 st030840 7.9285 µM -0.038002284230812 0.489023006309423 no 1714 0.484842930396254 2509 5499307 SGTC_3199 9111318 49.47 µM -0.038315973168804 0.488883525079043 no 1715 0.484717877695472 2506 8548020 SGTC_737 1950-0117 57.9 µM -0.0384706240472568 0.488814760339302 no 1716 0.484656226376587 2458 5393513 SGTC_1213 1315-0166 115 µM -0.038824057703817 0.488657609082837 no 1717 0.484515332008809 2544 768401 SGTC_866 0495-0101 262 µM -0.0388693906901343 0.488637452284599 no 1718 0.484497260404657 2496 635694 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0388959505698625 0.488625642748777 no 1719 0.484486672552384 2459 2346 DNA damaging agent; causes G2/M arrest. SGTC_2718 lomofungin 53.02 µM -0.0389129175814067 0.48861809857335 no 1720 0.484479908814688 2494 5351222 A RNA synthesis inhibitor. SGTC_916 4466-0038 42 nM -0.0390769508528237 0.488545163383655 no 1721 0.484414518742537 2471 5722064 YGL116W CDC20 SGTC_1728 st035614 33.7865 µM -0.0394890292700089 0.488361939948733 no 1722 0.484250250035052 2597 15945546 SGTC_1505 k297-0037 20.6 µM -0.03985439977862 0.488199486418637 no 1723 0.484104602950036 2487 4089396 SGTC_3337 9144342 33.5465 µM -0.0399757450331094 0.488145533494878 no 1724 0.484056231745691 2522 17682949 SGTC_2856 9022925 19.48 µM -0.0402224849662061 0.488035827849267 no 1725 0.483957875861293 2528 4944862 SGTC_3143 9086658 49.47 µM -0.0409260126606241 0.487723029974968 no 1726 0.48367743985601 2544 25236626 SGTC_268 camptothecin 39.6153 µM -0.0425060756791494 0.487020540525843 no 1727 0.483047634218971 2479 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3155 9099265 49.47 µM -0.0427758633676543 0.48690059800608 no 1728 0.482940102308143 2529 25236499 SGTC_598 3937-0236 20.2 µM -0.0430687529753031 0.486770386150427 no 1729 0.48282336384519 2516 1379313 SGTC_3345 9148410 3.559 µM -0.0433695684082835 0.486636652126869 no 1730 0.482703467879723 2501 4903596 SGTC_2165 5727197 32.143 µM -0.0435262715397562 0.486566986946227 no 1731 0.482641011353272 2735 1361712 SGTC_2634 4'-methoxyflavone 100 µM -0.0435862141992829 0.486540338472792 no 1732 0.482617120365093 2503 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2714 st079313 56.9 µM -0.0436653971985801 0.486505136488996 no 1733 0.482585560965183 2485 2939799 SGTC_3215 9129942 49.47 µM -0.0438171457637602 0.486437674694251 no 1734 0.482525079933429 2488 17682944 SGTC_784 4579-0127 173 µM -0.0443325393057748 0.486208552713102 no 1735 0.482319667274139 2610 1948547 SGTC_2773 thioridazine 9.09 µM -0.0448179738422998 0.485992753389699 no 1736 0.482126199216574 2484 5452 An antipsychotic. SGTC_2057 5236571 38.335 µM -0.0456391811043136 0.485627696088195 no 1737 0.481798919844525 2497 54684039 YBR257W POP4 SGTC_2849 9019321 12.99 µM -0.0465757564123081 0.485211368100043 no 1738 0.481425677317841 2553 16489627 SGTC_3234 9132280 49.47 µM -0.0465970931442394 0.485201883647139 no 1739 0.481417174425249 2538 17612295 SGTC_907 3448-6986 75.5 µM -0.048207080871004 0.484486247841852 no 1740 0.480775603515773 2517 590582 SGTC_3020 9089140 49.47 µM -0.0482714241442014 0.484457648429427 no 1741 0.480749964112773 2517 17217859 SGTC_3052 9092717 49.47 µM -0.0484453247939847 0.484380353160034 no 1742 0.480680668863054 2563 25237534 SGTC_74 000s-0487 160.283 µM -0.0495790972089422 0.4838764291116 no 1743 0.48022890207691 2488 677548 SGTC_920 mycophenolic acid 780.421 nM -0.0508963189768232 0.483291000334959 no 1744 0.479704069370546 2512 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1687 st020778 55.3625 µM -0.0513645277970162 0.483082917247325 no 1745 0.479517525080509 2506 4259299 SGTC_2032 5185112 25.99 µM -0.0514428647724959 0.483048102888702 no 1746 0.479486314410731 2523 5718189 SGTC_3174 9107204 49.47 µM -0.0520016789963197 0.482799759578151 no 1747 0.479263677790117 2533 3938802 SGTC_2260 7964312 200 µM -0.0526829327436555 0.482497011806016 no 1748 0.478992268918379 2645 231951 SGTC_1324 1418-0026 34.4 µM -0.0527101506810751 0.482484916418794 no 1749 0.47898142559836 2589 1372513 SGTC_3082 9117008 49.47 µM -0.0532078138332635 0.482263762597541 no 1750 0.478783164948872 2544 41448529 SGTC_2045 5106652 78.05 µM -0.0534775119858747 0.48214391517832 no 1751 0.478675723920447 2523 673349 SGTC_2520 obtusaquinone 4.71 µM -0.0534824243805252 0.482141732242364 no 1752 0.478673766959084 2537 5967872 SGTC_2447 5741742 33.78 µM -0.0536216046883539 0.482079884482622 no 1753 0.478618321610356 2556 1776504 SGTC_694 1315-0438 43.2 µM -0.0538872589351956 0.481961836509516 no 1754 0.478512493906772 2538 6793154 SGTC_3289 9119912 71.43 µM -0.0546063397322175 0.481642308717371 no 1755 0.478226043960508 2554 17014829 SGTC_2275 7947463 200 µM -0.0557548612678277 0.48113198094519 no 1756 0.477768547231174 2486 1225414 SGTC_1227 3909-8010 46.6 µM -0.0563417746989276 0.480871206928554 no 1757 0.477534770135766 2531 15982272 SGTC_3252 9135871 49.47 µM -0.0563436795936543 0.480870360569898 no 1758 0.477534011397984 2602 17682838 SGTC_2487 5918373 44.05 µM -0.0565091651893444 0.480796834439204 no 1759 0.477468097214151 2500 2876279 SGTC_1294 1000-1494 117 µM -0.0576119284939197 0.480306887637396 no 1760 0.477028873946076 2506 712797 YDL207W GLE1 SGTC_207 4185-0010 4.486 µM -0.0576415650035193 0.480293720837225 no 1761 0.477017070304648 2501 3761753 SGTC_3251 9135047 49.47 µM -0.0586101173507332 0.47986342785679 no 1762 0.476631326028727 2595 17682963 SGTC_2495 cafestol 54.53 µM -0.0586683185406109 0.479837571903306 no 1763 0.476608146998813 2686 16667697 An anti-infammatory. SGTC_2546 rhodinyl acetate 100 µM -0.0596212193848093 0.479414256621533 no 1764 0.476228658902521 2528 6708682 SGTC_1011 4112-3381 17.4 µM -0.0607432107265946 0.478915854623112 no 1765 0.475781859006573 2662 2877139 SGTC_3188 9110789 49.47 µM -0.0616636838645127 0.478506994007661 no 1766 0.475415330492677 2550 849217 SGTC_1504 k297-0033 30 µM -0.0617104597126223 0.478486217464882 no 1767 0.475396705100454 2493 4388117 SGTC_950 1165-0508 94.1 µM -0.06205846783326 0.478331643686693 no 1768 0.47525813554112 2559 6148369 SGTC_3170 9103054 49.47 µM -0.0625648659003764 0.478106724124263 no 1769 0.475056503766063 2566 16432970 SGTC_848 0368-0089 85.6 µM -0.0626074986178564 0.478087788879164 no 1770 0.475039529050347 2511 762535 SGTC_2716 st080858 38.6235 µM -0.0633796229765489 0.477744859830636 no 1771 0.474732106566277 2533 5296050 SGTC_62 0180-0423 3.232 µM -0.0636652197067991 0.477618019897497 no 1772 0.474618399596783 2551 30102 YGL099W LSG1 SGTC_2862 9027634 71.43 µM -0.064874890375715 0.477080803230881 no 1773 0.474136806522531 2514 5012562 SGTC_3142 9086498 49.47 µM -0.0659255722504174 0.476614227503312 no 1774 0.473718540577342 2528 25236367 SGTC_3224 9130643 49.47 µM -0.0673553458523288 0.475979360337664 no 1775 0.47314940863208 2604 17644395 SGTC_1578 josamycin 24.2 µM -0.0682291702993272 0.475591383056122 no 1776 0.472801603264789 2533 5282165 A P450 substrate. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0683278560471889 0.475547568118882 no 1777 0.472762325011034 2680 94937 An inhibitor of serotonin biosynthesis. SGTC_3210 9128157 49.47 µM -0.0706780077914925 0.474504225849926 no 1778 0.471827012148085 2670 17590849 SGTC_2585 alliin 100 µM -0.071985441528185 0.473923870096921 no 1779 0.471306746884533 2593 87310 A garlic compound which reacts with lipids. SGTC_1867 st057372 64 µM -0.0743246351739915 0.472885666108784 no 1780 0.470376037603389 2533 688837 SGTC_2954 9074818 52.69 µM -0.0746239165033389 0.472752849259403 no 1781 0.470256972279106 2599 16648742 SGTC_586 0957-0265 8.15 µM -0.0755120150812135 0.472358741476681 no 1782 0.469903669089514 2530 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2764 methyldopa 94.69 µM -0.0761774800285275 0.472063448600808 no 1783 0.469638949476742 2578 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1941 st076221 61.8 µM -0.0764916951564265 0.471924024361864 no 1784 0.469513960462161 2657 2828568 SGTC_491 tetrandrine 80.3 µM -0.076549513784359 0.471898369325312 no 1785 0.469490961599354 2612 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2282 7944268 200 µM -0.0769059528385977 0.471740214277817 no 1786 0.469349180947453 2592 2970414 SGTC_3205 9113483 49.47 µM -0.0771365684627372 0.471637890531755 no 1787 0.469257451111869 2643 17018033 SGTC_2257 7960413 200 µM -0.0772250855204011 0.471598616166066 no 1788 0.469222242936803 2586 2974689 YIL048W NEO1 SGTC_1056 3448-1962 115 µM -0.0781027618056478 0.471209212677993 no 1789 0.468873155152194 2614 715507 SGTC_1835 st008666 49.2 µM -0.0788420056715448 0.470881249605897 no 1790 0.468579146161453 2563 690455 SGTC_1305 1181-0477 144 µM -0.081865194190697 0.469540230009423 no 1791 0.467376956257768 2625 6252086 SGTC_977 1348-1378 135 µM -0.0819199797700913 0.469515931478358 no 1792 0.467355173139502 2543 X977 SGTC_2001 4023502 57.655 µM -0.0825805254003373 0.469222974870298 no 1793 0.467092543427042 2633 108941 YCR052W RSC6 SGTC_2345 9052315 157.45 µM -0.0826198062132199 0.469205554078292 no 1794 0.467076926018084 2625 6469265 SGTC_3235 9132602 49.47 µM -0.0829654624778278 0.469052260257329 no 1795 0.46693950092679 2634 4912240 SGTC_941 3237-0776 460 µM -0.0831011794103077 0.468992072908887 no 1796 0.466885544029059 2638 760008 SGTC_3197 9113331 49.47 µM -0.0837523201783115 0.468703316784456 no 1797 0.46662667887374 2645 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_376 3970-0862 59.1 µM -0.0844054677154703 0.4684136872734 no 1798 0.466367030096724 2614 3135186 SGTC_2109 5483026 200 µM -0.085600492109102 0.467883813124554 no 1799 0.465892003625363 2595 759335 SGTC_325 2810-4341 181 µM -0.0858414599003637 0.467776974801725 no 1800 0.465796223931383 2583 774970 SGTC_349 k015-0014 24 µM -0.0859662511056259 0.467721646812463 no 1801 0.465746622796571 2545 2196908 SGTC_934 2950-0684 338 µM -0.0860878433911906 0.467667737710381 no 1802 0.465698293657788 2723 1121253 SGTC_2929 9013348 24.6 µM -0.0864304188762997 0.467515856786476 no 1803 0.465562133316548 2633 2995952 SGTC_481 bay k-8644 50 µM -0.0881050696435994 0.466773468437599 no 1804 0.464896583529436 2561 2303 A calcium channel antagonist. SGTC_411 enrofloxacin 100 µM -0.0893494352337762 0.466221904237549 no 1805 0.464402103753102 2643 71188 A bacterial gyrase inhibitor. SGTC_2792 7535235 81.82 µM -0.0896970281313375 0.466067845468071 no 1806 0.464263988815776 2639 1281891 SGTC_2181 6316240 54.2555 µM -0.0898259777388151 0.466010694217342 no 1807 0.464212752191678 2620 12779990 SGTC_2157 5649910 96.377 µM -0.090912522930268 0.465529158727764 no 1808 0.463781049771052 2574 2858091 SGTC_201 4262-0159 12.803 µM -0.0914565658447141 0.465288068509998 no 1809 0.463564908489615 2648 1341029 SGTC_847 0342-0274 5.54 µM -0.092246438610074 0.464938062578531 no 1810 0.463251121315152 2660 18097 SGTC_2850 9015429 58.44 µM -0.0925026636314427 0.464824530767935 no 1811 0.463149337512357 2614 6457570 SGTC_2674 ligustilide 100 µM -0.0932481789605061 0.464494213599698 no 1812 0.462853199910331 2646 5319022 A signalling regulator. SGTC_2292 7671323 168.05 µM -0.0939840278836395 0.464168203341624 no 1813 0.46256092223679 2667 937504 SGTC_1790 st045711 43.5 µM -0.0941828336750115 0.464080128609517 no 1814 0.462481960448365 2583 585119 SGTC_282 k297-0036 65.7 µM -0.0945998052057915 0.463895408044104 no 1815 0.462316352283251 2691 5061378 SGTC_900 1112-0045 141 µM -0.0953122743211409 0.463579798537596 no 1816 0.462033396770814 2606 56211 YIL048W NEO1 SGTC_123 0083-0120 66.675 µM -0.0961484070952856 0.463209437761198 no 1817 0.461701353029864 2575 16001701 SGTC_3164 9100705 49.47 µM -0.0962017146658148 0.463185826520758 no 1818 0.461680184513455 2701 17174235 SGTC_2385 9074692 200 µM -0.0979055683178281 0.462431216397025 no 1819 0.461003639177351 2604 17046906 SGTC_2354 9060492 162 µM -0.0981964013708315 0.462302424421168 no 1820 0.460888169972815 2663 6471895 SGTC_1563 conessine 56.1 µM -0.0984160558213687 0.462205155666111 no 1821 0.460800962934727 2641 441082 An anti-amoebic, histamine inhibitor. SGTC_1575 cyproterone acetate 48 µM -0.0992515824001873 0.461835183270357 no 1822 0.460469260085564 2604 9880 An androgen receptor antagonist and liver toxin. SGTC_1760 st045453 10.4495 µM -0.102711964783019 0.460303276000935 no 1823 0.459095788674207 2597 3323419 YIL048W NEO1 SGTC_1856 st057054 55.7 µM -0.103740729785795 0.459847955489511 no 1824 0.458687551661529 2770 1266018 SGTC_1952 st077036 64.1 µM -0.103934329029365 0.459762276380092 no 1825 0.458610732000018 2582 2937007 SGTC_2172 5754775 163.918 µM -0.104983874932457 0.459297822901318 no 1826 0.458194301972737 2617 2263357 SGTC_2878 9043973 25.97 µM -0.105045001838676 0.45927077423771 no 1827 0.458170049960727 2761 6465167 SGTC_2679 rapamycin 1 nM -0.105691967403796 0.458984503476887 no 1828 0.457913376868254 2629 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1887 st057648 70.8 µM -0.106940983365985 0.458431896410979 no 1829 0.45741789978841 2751 688672 SGTC_144 4161-2749 112.381 µM -0.107907560242795 0.458004305065077 no 1830 0.457034509968483 2579 797501 YMR168C CEP3 SGTC_2569 tetrandrine 100 µM -0.109994156660451 0.457081409211131 no 1831 0.456207004552721 2667 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1072 oxiconazole 14.9 nM -0.110051743076538 0.457055942156471 no 1832 0.456184169525243 2608 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1783 st039459 87.517 µM -0.110481808579844 0.456865755288222 no 1833 0.456013638097169 2812 729761 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.110664780244563 0.456784843147343 no 1834 0.455941087838701 2840 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2363 9053361 176 µM -0.110739615517669 0.456751750658689 no 1835 0.455911415260759 2714 6469797 YMR079W SEC14 SGTC_2138 5575593 77.673 µM -0.112709253476566 0.455880876566249 no 1836 0.455130532393907 2606 762213 SGTC_2316 5844804 197.44 µM -0.113218246836651 0.45565585978718 no 1837 0.454928764898194 2699 776813 SGTC_3008 9078912 71.4286 µM -0.113312755104408 0.45561408095107 no 1838 0.45489130262982 2632 16648731 SGTC_2688 kanamycin b 96.69 µM -0.114114380639895 0.455259729814315 no 1839 0.454573561295377 2676 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1834 st055981 52.8 µM -0.115820023854583 0.454505884825911 no 1840 0.453897590286412 2768 471719 YDL150W RPC53 SGTC_2724 maprotiline 69.64 µM -0.1161167792895 0.454374744158885 no 1841 0.453779995408869 2619 4011 A tricyclic antidepressant. SGTC_417 st075190 100 µM -0.117340238930723 0.453834131711232 no 1842 0.453295219602641 2645 222757 SGTC_1546 5-methoxyflavanone 78.7 µM -0.11758593267034 0.453725576829689 no 1843 0.453197875857796 2677 147795 SGTC_888 0916-0002 6.97 µM -0.118255156854043 0.453429911019782 no 1844 0.452932743827977 2779 2802138 YIL048W NEO1 SGTC_1148 3909-7663 27.7 µM -0.118763336629376 0.453205412480005 no 1845 0.452731428090496 2769 4084526 SGTC_3122 9126309 49.47 µM -0.118773512847744 0.453200917085302 no 1846 0.452727396899104 2596 17591206 SGTC_885 0865-0106 16.8 µM -0.119901561267509 0.452702633436135 no 1847 0.452280563843653 2614 2793380 SGTC_326 k292-0812 17.5 µM -0.120298956053709 0.452527113169856 no 1848 0.452123165528058 2588 3579357 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.120378850898773 0.452491826547245 no 1849 0.452091522049646 2644 5357218 A potent inhibitor of glutathione S-transferases. SGTC_511 blebbistatin 171 µM -0.121611645681036 0.451947394041208 no 1850 0.451603295015821 2764 3476986 A myosin inhibitor. SGTC_827 3253-0474 693 µM -0.121747629750749 0.451887345644798 no 1851 0.451549445347551 2648 5402065 SGTC_782 0083-0095 30.5 µM -0.122401733584133 0.451598519229116 no 1852 0.451290432817066 2599 3591729 An indicator and reagent. SGTC_1203 3992-3522 103 µM -0.122630047266117 0.451497710949503 no 1853 0.451200029869332 2879 5322312 SGTC_1561 5-methoxyflavone 52.9 µM -0.123687930678076 0.451030660254633 no 1854 0.450781184098984 2604 94525 SGTC_2751 anetholtrithion 17.25 µM -0.12403637276854 0.450876839472768 no 1855 0.450643238059021 2731 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_954 1189-0853 2.85 µM -0.124275155174743 0.45077143253839 no 1856 0.450548709042497 2594 2828194 SGTC_696 1560-0013 611 µM -0.125320595398879 0.450309979505176 no 1857 0.450134873973687 2782 1650269 SGTC_1288 0973-0013 65.5 µM -0.126461190273848 0.449806602235359 no 1858 0.449683434015773 2718 4315430 SGTC_2198 6589944 200 µM -0.127059712656193 0.449542489375832 no 1859 0.449446568800416 2675 5290268 SGTC_1716 st033144 30.6155 µM -0.129070376386428 0.448655398421861 no 1860 0.448650981062979 2695 674617 SGTC_456 gingerol 170 µM -0.129248447392082 0.448576847029975 no 1861 0.448580531096144 2786 442793 A herb. SGTC_735 3076-0345 636 µM -0.129387252578149 0.44851561813094 no 1862 0.448525616931473 2731 2888990 SGTC_1386 3228-0095 33.8 µM -0.130032494009505 0.44823100928027 no 1863 0.448270359216166 2743 870181 SGTC_433 pimozide 108 µM -0.130936309716386 0.447832391012579 no 1864 0.44791284546746 2629 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2035 5154463 94.595 µM -0.131103816034295 0.447758519913607 no 1865 0.447846591231183 2728 2769623 SGTC_227 fluconazole 33.516 µM -0.131646461265828 0.447519223188752 no 1866 0.447631967265786 2642 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2511 berberine 10.47 µM -0.132134982379742 0.447303810555947 no 1867 0.447438763276846 2669 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.13216828832008 0.447289124918119 no 1868 0.447425591647705 2724 5379071 SGTC_518 1021-0119 62.6 µM -0.132829157709058 0.446997741764693 no 1869 0.447164247080544 2701 1097762 SGTC_1272 0839-0021 27 µM -0.133251883500943 0.446811373220335 no 1870 0.446997089779396 2719 5027250 SGTC_2762 leflunomide 42.06 µM -0.133396067722444 0.446747808921128 no 1871 0.446940077559863 2651 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_540 1187-0821 17.3 µM -0.135207424461683 0.445949380779026 no 1872 0.446223938564153 2652 847520 SGTC_1664 st014217 9.02 µM -0.135458683318403 0.445838645592026 no 1873 0.446124614522222 2656 3982782 SGTC_2162 5663267 200 µM -0.135505989949304 0.445817797013747 no 1874 0.446105914322413 2671 6456493 SGTC_209 4077-0173 175.592 µM -0.135723472023659 0.445721952081708 no 1875 0.446019945713446 2731 15993494 SGTC_2921 7974240 10.71 µM -0.135728314681163 0.445719817945669 no 1876 0.44601803148556 2775 2979074 YDR527W RBA50 SGTC_3015 9080845 49.47 µM -0.138668810889428 0.444424247997365 no 1877 0.44485593262131 2753 5296973 SGTC_532 1548-0774 215 µM -0.138713920514339 0.444404377478723 no 1878 0.444838108735527 2862 5932993 SGTC_1771 st048882 4.1505 µM -0.13936622115789 0.444117058609893 no 1879 0.444580381720325 2659 4580403 SGTC_3103 9120822 49.47 µM -0.141190573562782 0.443313642489772 no 1880 0.4438596963425 2867 17141819 SGTC_728 3030-5151 22.5 µM -0.142980691701812 0.442525529034256 no 1881 0.44315271514655 2656 3125388 SGTC_1569 carminic acid 40.6 µM -0.14333647273741 0.442368920650686 no 1882 0.443012226069144 2723 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_527 4476-4215 268 µM -0.143509410026242 0.442292800031984 no 1883 0.44294394002377 2677 4418754 SGTC_331 k048-0133 24.5 µM -0.143806662434005 0.44216196546115 no 1884 0.442826570851805 2665 6813582 SGTC_1692 fluoroquinolonic acid 71 µM -0.145911406629443 0.441235751223356 no 1885 0.441995663388754 2771 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1630 st005209 31.3 µM -0.146518856568477 0.440968496180776 no 1886 0.441755902582362 2639 3367314 SGTC_997 3996-0078 137 µM -0.147189165615397 0.44067361670652 no 1887 0.441491356021771 2737 735687 SGTC_2177 5811945 192 µM -0.14756311980421 0.440509122671456 no 1888 0.441343781261381 2813 5343475 SGTC_1240 0356-0016 42.1 µM -0.148382693893958 0.440148646409521 no 1889 0.441020378575768 2745 4305613 SGTC_707 0865-0008 204 µM -0.149925539358782 0.439470185875788 no 1890 0.440411680977694 2692 723043 SGTC_3259 9138485 49.47 µM -0.150088107706547 0.43939870736885 no 1891 0.44034755119035 2881 17646153 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.150827223819896 0.439073755669351 no 1892 0.440056005212793 2807 61125 An anti-inflammatory. SGTC_1880 MG-132 525 µM -0.151572529511849 0.438746124300632 no 1893 0.439762050651545 2733 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1487 3970-0795 2.82 µM -0.151773442337026 0.438657811546317 no 1894 0.439682814692335 2754 3765103 SGTC_1331 1472-0049 76.2 µM -0.153141814259753 0.438056414756742 no 1895 0.439143220877942 2676 24051409 SGTC_673 1082-0474 110 µM -0.153375695856823 0.437953638526085 no 1896 0.43905100499947 2695 3098046 SGTC_2580 diallyl disulphide 81.36 µM -0.153643587529733 0.437835922152061 no 1897 0.438945383541398 2712 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2654 protoveratrine a 100 µM -0.153690934991571 0.437815117405527 no 1898 0.438926716343378 2679 5702278 A heart drug and vasodilator. SGTC_2814 7977482 42.97 µM -0.15400157793257 0.437678623380258 no 1899 0.438804245709171 2814 6456762 SGTC_961 1252-1571 372 µM -0.156572140166747 0.436549424938201 no 1900 0.437791030310632 2806 6813498 SGTC_2134 5324836 1.464 µM -0.157738046369467 0.436037434638165 no 1901 0.437331609554624 2733 699272 SGTC_2832 7992762 51.95 µM -0.160408635162306 0.434865090667885 no 1902 0.436279593912611 2681 2985177 SGTC_3038 9091290 49.47 µM -0.160849338288089 0.434671684089928 no 1903 0.436106032397966 2796 25236843 SGTC_734 2023-0417 80 µM -0.16112196693705 0.434552046349383 no 1904 0.435998669584093 2811 3935732 SGTC_1286 0929-0070 131 µM -0.161723474361962 0.434288107815665 no 1905 0.43576180900739 2807 1420408 SGTC_1608 st001473 40.5 µM -0.162800707431134 0.433815496453914 no 1906 0.435337675625239 2687 7292267 SGTC_3214 9129694 49.47 µM -0.163527511664307 0.433496681130841 no 1907 0.435051556758354 2781 17158655 SGTC_751 0833-0568 350 µM -0.164991845708393 0.432854477282863 no 1908 0.434475200139238 2768 6954252 SGTC_373 0844-0104 25.9 µM -0.165873506884011 0.4324678980442 no 1909 0.434128248543151 2803 5375804 SGTC_1492 4158-0558 28.5 µM -0.166037914163451 0.432395818034032 no 1910 0.434063556541146 2807 3967268 SGTC_1262 0737-0114 49.6 µM -0.16616412251837 0.432340486855326 no 1911 0.434013896488326 2746 765919 SGTC_3019 9081971 49.47 µM -0.166171355179349 0.432337316014654 no 1912 0.434011050635962 2839 16451803 SGTC_1420 4'-methoxyflavone 42 µM -0.166543985195159 0.432173958747401 no 1913 0.433864435645763 2698 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_611 3453-1652 23.7 µM -0.167922700307313 0.431569644879454 no 1914 0.433322045721293 2762 1560575 SGTC_403 arphamenine a 50 µM -0.168826808675403 0.431173445916794 no 1915 0.432966435362336 2698 5487158 An arginine aminopeptidase inhibitor. SGTC_2261 9010538 184.68 µM -0.169610346714047 0.430830139357932 no 1916 0.432658292477043 2837 6457250 SGTC_1416 3966-0321 25.3 µM -0.170324663169389 0.430517207713336 no 1917 0.432377408118641 2765 582530 YLR208W SEC13 SGTC_52 0329-0193 875 nM -0.17128506129076 0.430096540067938 no 1918 0.43199981312068 2935 3739292 SGTC_526 4469-0568 170 µM -0.173006281274943 0.429342820740672 no 1919 0.431323245166334 2686 2901964 SGTC_3209 9113616 49.47 µM -0.1737124380339 0.429033670227572 no 1920 0.431045731004955 2834 16649353 SGTC_26 0302-0163 425.158 µM -0.173750265974599 0.429017110645141 no 1921 0.431030865875325 2705 3100915 SGTC_3324 9138759 60.749 µM -0.175666245677298 0.428178534237203 no 1922 0.430278077462482 2842 45595710 SGTC_3112 9123419 49.47 µM -0.175715259485985 0.428157086355987 no 1923 0.43025882324908 2699 17015854 SGTC_1402 3909-7673 35.9 µM -0.176828142705694 0.427670158645077 no 1924 0.42982169134814 2686 5328014 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.178456690844324 0.426957807111622 no 1925 0.429182165442096 2707 364106 SGTC_1042 0350-0096 82 µM -0.179310236136686 0.42658454848438 no 1926 0.428847054918664 2678 3122515 SGTC_382 3229-0966 23.2 µM -0.179356016887114 0.426564530241415 no 1927 0.428829082379553 2892 5722370 SGTC_1162 k048-0130 20.1 µM -0.179730550992938 0.426400767323337 no 1928 0.428682053881127 2718 6797406 SGTC_2945 9067681 61.76 µM -0.180200823809253 0.426195161167569 no 1929 0.428497455856699 2667 16456930 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.180886994951086 0.425895198943005 no 1930 0.428228138494127 2722 688664 SGTC_2772 vinpocetine 57.06 µM -0.181306876555975 0.425711667297666 no 1931 0.428063354384932 2901 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3002 9075603 71.4286 µM -0.181419260591615 0.425662546590615 no 1932 0.42801925097595 2730 20105405 SGTC_974 1326-0144 138 µM -0.181895953399766 0.425454206986441 no 1933 0.427832190121289 2743 5411856 SGTC_1570 verbenone 133 µM -0.181980931611294 0.425417069262778 no 1934 0.427798845197294 2882 29025 A natural terpanoid with antifungal properties. SGTC_160 3453-0671 289.699 µM -0.182093831933002 0.425367729862871 no 1935 0.427754544607847 2759 5322268 SGTC_2937 9044753 11.33 µM -0.182306578164875 0.425274759244335 no 1936 0.427671068282458 2717 6465530 YGL099W LSG1 SGTC_2778 tioconazole 65.09 nM -0.183519547651429 0.424744768174073 no 1937 0.427195191211531 2698 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2379 9035213 200 µM -0.183828631525261 0.424609739745806 no 1938 0.427073947089109 2837 646551 SGTC_453 enantio-paf c16 10 µM -0.184037961211968 0.424518295616062 no 1939 0.426991837386181 2839 13871343 A lipid and platelet activating factor SGTC_2060 5238662 140 µM -0.186113813915588 0.423611695344111 no 1940 0.426177754618466 2838 790130 SGTC_2985 9022375 71.43 µM -0.186264963493875 0.423545698563632 no 1941 0.426118490848777 2936 4939335 SGTC_1623 st003709 20.3 µM -0.186536046767644 0.423427340237603 no 1942 0.42601220682858 2722 16192618 SGTC_796 1234-0020 70.7 µM -0.186619136244247 0.423391063722489 no 1943 0.425979630890303 2723 46495034 SGTC_2909 7941780 10.49 µM -0.187178216960967 0.423146988339262 no 1944 0.425760451669681 2776 1243215 SGTC_2147 5545932 89.7195 µM -0.188794917872318 0.422441358682077 no 1945 0.425126777582435 2763 797404 SGTC_2386 9075165 157.42 µM -0.189007943633222 0.42234839938717 no 1946 0.42504329544456 2732 16452277 SGTC_3263 9137018 49.47 µM -0.189009861864741 0.422347562336924 no 1947 0.425042543728825 2777 43844957 SGTC_917 harmaline 728.087 nM -0.189127053892715 0.422296424432811 no 1948 0.424996619084816 2851 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2950 9072895 21.46 µM -0.189972409201737 0.421927584109656 no 1949 0.424665375533047 2849 17332245 SGTC_2331 7980721 200 µM -0.189987416072184 0.421921037020172 no 1950 0.424659495729158 2825 2981221 SGTC_2611 pyromycin 23.93 µM -0.190464653362143 0.421712842632707 no 1951 0.42447251934594 2779 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_51 1013-0126 23.419 µM -0.191468304557808 0.421275072059501 no 1952 0.424079355217806 2958 1627850 SGTC_2750 bromebric acid 70.15 µM -0.195915607005832 0.419336434592118 no 1953 0.422338110682634 2889 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_810 3825-7150 143 µM -0.196519550955415 0.419073317349871 no 1954 0.422101765782842 2946 22330411 YGL099W LSG1 SGTC_3281 9140613 49.47 µM -0.198426570761232 0.418242733651028 no 1955 0.421355665135069 2788 16013766 SGTC_1654 st012436 41.8 µM -0.198447031074655 0.418233824332471 no 1956 0.42134766178699 2779 4323132 SGTC_1423 4048-0112 5.59 µM -0.198486650946945 0.418216572220268 no 1957 0.421332163992217 2840 X1423 SGTC_759 3486-0358 89.3 µM -0.200135404256953 0.417498777525402 no 1958 0.420687342432587 2853 875103 SGTC_538 2922-0838 53.3 µM -0.200735014654366 0.417237801544536 no 1959 0.420452889601131 2868 777039 SGTC_680 0417-1641 114 µM -0.201487437851361 0.416910366517097 no 1960 0.420158725579311 2749 2835990 SGTC_364 0083-0097 67.7 µM -0.201756381052613 0.416793343392113 no 1961 0.420053591553104 2904 5207356 SGTC_867 0518-0118 155 µM -0.202359205588164 0.416531067925194 no 1962 0.419817958921861 2775 6848158 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.203636985325157 0.415975257536109 no 1963 0.419318594287789 2787 688669 SGTC_2490 carminic acid 95.39 µM -0.203737537950339 0.415931526133601 no 1964 0.419279303171676 2727 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_712 r015-0009 80.6 µM -0.204805213330882 0.41546724710422 no 1965 0.418862156852177 2882 6813872 YLR060W FRS1 SGTC_1109 tnp00067 928.257 nM -0.205406332699979 0.415205902002005 no 1966 0.418627336492341 2794 676295 SGTC_1713 st033146 12.748 µM -0.205633246148085 0.415107257935213 no 1967 0.418538702900009 2878 674619 SGTC_2837 9008476 45.46 µM -0.205643286171435 0.415102893448669 no 1968 0.418534781309324 2978 2992805 SGTC_740 k014-0057 261 µM -0.207123624510898 0.414459492274702 no 1969 0.417956656220196 2879 4012779 SGTC_1333 1482-0047 286 µM -0.207797403251014 0.414166722917711 no 1970 0.417693580133191 2866 3811116 SGTC_1479 0549-0158 134 µM -0.208393170175852 0.413907890862415 no 1971 0.417460994341533 2811 5440202 SGTC_1502 4534-4282 27.7 µM -0.208702473934984 0.413773528005074 no 1972 0.417340254374632 2802 3278949 SGTC_574 1315-0397 40 µM -0.209471812752409 0.413439367790607 no 1973 0.417039968722993 2768 6794277 SGTC_2821 7996764 71.43 µM -0.211410855633653 0.412597428434592 no 1974 0.416283343302746 2992 2987135 SGTC_1077 5-fluorocytosine 377 nM -0.211564500225798 0.41253073254042 no 1975 0.416223403543882 2853 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1293 1000-1278 195 µM -0.212064391564797 0.412313751175444 no 1976 0.416028399649431 2924 678847 SGTC_3195 9113082 49.47 µM -0.212426796834196 0.41215646336228 no 1977 0.41588704097089 2799 17018038 SGTC_2118 5526350 200 µM -0.214616832940062 0.411206265091305 no 1978 0.41503303447284 2913 743594 SGTC_1469 k284-2957 126 µM -0.214783293500691 0.411134063514609 no 1979 0.414968139392614 2819 23884841 SGTC_305 1682-2595 20.8 µM -0.216251525793027 0.410497354489748 no 1980 0.414395845911793 2835 226033 SGTC_1816 st051957 91.6 µM -0.217344552882228 0.410023508803549 no 1981 0.413969919326443 2828 674121 SGTC_2003 4023581 200 µM -0.217402197550182 0.409998522507773 no 1982 0.413947459378601 2921 16641307 SGTC_1380 2291-0730 164 µM -0.219624155129941 0.409035686178992 no 1983 0.413081938804408 2889 2999191 SGTC_483 fpl-64176 144 µM -0.219685491097735 0.409009115344113 no 1984 0.413058052535595 2795 3423 SGTC_2276 7947513 42.08 µM -0.219947783227333 0.408895494711647 no 1985 0.412955910876119 2873 2105100 SGTC_6 0844-0013 19.835 µM -0.219993163678413 0.408875837423885 no 1986 0.41293823944311 2843 1584900 SGTC_889 0919-1524 82.7 µM -0.220157459884594 0.408804671740972 no 1987 0.41287426294312 2858 3905452 SGTC_1631 benzylvanillin 81.9 µM -0.220413754821526 0.408693662374337 no 1988 0.412774467006376 2945 75506 SGTC_83 0170-0301 39.027 µM -0.221023795306959 0.408429464210617 no 1989 0.412536952574424 2788 3089716 SGTC_3001 9076041 71.4286 µM -0.221232716074578 0.408338993738115 no 1990 0.412455618285135 2785 16004211 SGTC_588 3970-1144 52.9 µM -0.222049756933048 0.407985231575191 no 1991 0.412137574797988 2938 1888707 SGTC_12 0849-0099 9.267 µM -0.223866068575184 0.407199074452766 no 1992 0.411430759507025 2814 6071388 SGTC_1859 st055998 20 µM -0.224064489261486 0.40711321428974 no 1993 0.411353561727252 2938 676301 SGTC_200 k038-0079 37.545 µM -0.224352102036141 0.406988767047299 no 1994 0.411241668864982 2833 3436683 SGTC_1897 st060201 15 µM -0.22439470716167 0.406970333023245 no 1995 0.411225094382413 2828 611878 SGTC_447 ml7 120 µM -0.225245136966457 0.406602419439585 no 1996 0.410894288642742 2867 4216 Selective myosin light chain kinase inhibitor. SGTC_2591 skatole 100 µM -0.226096603207574 0.406234140048245 no 1997 0.410563143220746 2946 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1375 2910-0797 186 µM -0.22616014777701 0.40620665883328 no 1998 0.410538432529694 2879 742508 SGTC_945 3381-0768 11.3 µM -0.228208976004192 0.405320847378323 no 1999 0.409741891850445 2943 1126236 YIL048W NEO1 SGTC_1409 3909-8004 61.9 µM -0.228796934115098 0.405066732842665 no 2000 0.409513374907003 2842 2119279 SGTC_346 4513-0042 7.16 µM -0.229681288363626 0.404684591781036 no 2001 0.409169717975758 2815 2827372 SGTC_1602 st001878 87.6 µM -0.230096347866922 0.404505270448089 no 2002 0.409008451372383 2989 595405 YLR310C CDC25 SGTC_1786 berberine 21.6 µM -0.231059118199096 0.404089394698111 no 2003 0.408634437355105 2810 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2444 5485484 36.41 µM -0.232342485787555 0.4035352031833 no 2004 0.408136008131003 2945 6790631 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.232751976904587 0.403358414961398 no 2005 0.407977002826453 2798 442882 SGTC_1814 st052110 31.539 µM -0.234205081002467 0.402731230828925 no 2006 0.407412885319032 2942 674163 SGTC_2719 novobiocin 32.65 µM -0.235363532806045 0.402231402753929 no 2007 0.406963293852104 2934 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2225 6654152 15.4 µM -0.237028806004222 0.401513180626912 no 2008 0.406317221489181 2875 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2013 4024628 200 µM -0.237514042047124 0.401303963761071 no 2009 0.406129013429344 2978 5230760 SGTC_455 paf C-16 10 µM -0.237686331608736 0.40122968531182 no 2010 0.406062192850455 2806 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_235 0330-0087 5 mM -0.238847871581556 0.40072900891758 no 2011 0.405611774069493 2850 46494818 YHR062C RPP1 SGTC_825 1988-2224 89.6 µM -0.242128635714733 0.399315733942001 no 2012 0.404340245077689 2827 1180859 SGTC_3104 9120930 49.47 µM -0.242904964408116 0.398981502273823 no 2013 0.404039509846077 2917 17014836 SGTC_2858 9025781 8.96 µM -0.245081797028815 0.398044709359901 no 2014 0.403196548529476 2940 4894980 YPL153C RAD53 SGTC_2174 5790901 200 µM -0.246028084677234 0.397637660380448 no 2015 0.402830246061196 2921 786020 SGTC_2676 harmalol 100 µM -0.246310265122684 0.397516301010968 no 2016 0.402721032135908 2918 5459187 A monoamine oxidase inhibitor SGTC_2012 4023501 200 µM -0.24729174185952 0.397094267586653 no 2017 0.402341224701306 2934 3477460 SGTC_1510 1123-0200 71.5 µM -0.249286359813344 0.39623695674394 no 2018 0.401569640817568 3041 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_136 0097-0015 404.482 µM -0.249578674864329 0.396111358249389 no 2019 0.401456595889246 2835 4861337 SGTC_1567 st069303 68.4 µM -0.251210003543241 0.395410626476478 no 2020 0.400825875398208 2957 5581319 SGTC_203 k066-0004 30.888 µM -0.25377025843961 0.39431155986514 no 2021 0.399836525875534 2861 6795412 SGTC_166 k072-0058 166.424 µM -0.253885692571782 0.394262026030918 no 2022 0.399791934198467 2921 5846229 SGTC_1390 3413-2614 145 µM -0.253998269206422 0.394213720021889 no 2023 0.399748447618326 2911 3421432 SGTC_3154 9100113 49.47 µM -0.254038796596988 0.39419633034184 no 2024 0.399732792830289 2877 25237525 SGTC_774 k060-0086 136 µM -0.25475189220805 0.393890386514825 no 2025 0.399457366976358 2877 5911235 SGTC_2412 st077135 33.4 µM -0.256462517122898 0.393156733779567 no 2026 0.398796859884299 3133 13258915 SGTC_1801 st050089 28.441 µM -0.257848268165296 0.392562690879658 no 2027 0.398262005524791 2864 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2160 5660466 132.927 µM -0.258375250397193 0.392336850056162 no 2028 0.398058657799063 2849 2859134 SGTC_635 k038-0028 24.7 µM -0.258406256703586 0.392323563279918 no 2029 0.398046694193258 2903 4035102 SGTC_1646 st011709 75.6 µM -0.258602880391064 0.392239309312658 no 2030 0.397970830300846 2959 5757843 SGTC_303 1348-1668 34.2 µM -0.25889572511219 0.392113833647135 no 2031 0.397857848317212 2886 5380509 SGTC_112 phenothiazine 287.218 µM -0.259593778217095 0.391814782932948 no 2032 0.397588568053809 2947 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2159 5658611 73.75 µM -0.260396119271795 0.391471133501162 no 2033 0.397279118053926 2948 793844 SGTC_1509 1326-1131 80 µM -0.260541052970803 0.391409066199804 no 2034 0.3972232263526 2944 768313 SGTC_3236 9132701 49.47 µM -0.262108830921268 0.390737848317747 no 2035 0.396618769321147 2926 24282524 SGTC_2942 9052777 62.25 µM -0.264517287988756 0.389707342316195 no 2036 0.395690672594444 2901 6469503 SGTC_1029 k015-0030 64.7 µM -0.264819079891814 0.389578269164746 no 2037 0.3955744189311 2986 2208316 SGTC_857 0438-0306 1.35 µM -0.265321107890438 0.389363584175301 no 2038 0.395381052639916 2971 4686136 SGTC_2521 angolensin 13.4 µM -0.267146001785114 0.388583479667171 no 2039 0.394678374949419 3027 821428 A flavenoid. SGTC_1184 1269-1718 139 µM -0.26862844221408 0.387950097410756 no 2040 0.394107811404798 3030 5403821 SGTC_75 0159-0059 199.013 µM -0.269096093838565 0.387750351977717 no 2041 0.393927868136453 3186 5377270 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.27064954150582 0.387087050003252 no 2042 0.393330294363249 2895 641818 YHR062C RPP1 SGTC_2277 7947813 106.88 µM -0.27065258273686 0.387085751759733 no 2043 0.393329124721097 3113 1246798 SGTC_698 k064-0052 127 µM -0.271113384217596 0.38688905900026 no 2044 0.393151913920811 2868 5088751 SGTC_2690 usnic acid 100 µM -0.271589237843353 0.386685971729344 no 2045 0.392968937739229 3130 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3081 9117243 49.47 µM -0.272032700287318 0.386496736464231 no 2046 0.392798437964601 3064 45595589 SGTC_2662 daunorubicin 22.37 µM -0.272420144347744 0.386331427575482 no 2047 0.39264949263448 2869 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1929 genistein trimethyl ether 50.5 µM -0.272620647590811 0.38624588792223 no 2048 0.39257241923532 3086 136420 SGTC_2317 5986382 200 µM -0.272747189692653 0.386191904770528 no 2049 0.392523778649571 2953 877883 SGTC_50 0929-0078 56.389 µM -0.273569393247853 0.38584120454935 no 2050 0.392207778807728 2898 1377751 SGTC_107 0358-0022 2.6945 µM -0.27503439530325 0.385216558348896 no 2051 0.391644906641613 2967 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_875 0709-0210 25.7 µM -0.276168633353898 0.384733147363767 no 2052 0.391209273834331 2994 6251364 SGTC_2124 5246320 200 µM -0.276873325367843 0.384432898595415 no 2053 0.390938687728298 2986 579342 SGTC_1436 4092-1007 8.32 µM -0.277112058879816 0.384331196901367 no 2054 0.390847031318829 2917 2881121 SGTC_1307 1187-1599 12.2 µM -0.277613046193314 0.384117799643907 no 2055 0.39065470812794 2887 1538471 SGTC_3121 9125696 49.47 µM -0.27820920595596 0.3838639091287 no 2056 0.390425884197435 2911 1235365 SGTC_3006 9075424 71.4286 µM -0.279600041321641 0.383271778788564 no 2057 0.389892187697058 2932 7465181 SGTC_2913 7966556 36.57 µM -0.279653592900161 0.383248985331101 no 2058 0.38987164282937 3013 2976516 SGTC_360 0957-0399 1.01 µM -0.281465885414531 0.382477847898338 no 2059 0.389176545163277 3042 6752301 YPR165W RHO1 SGTC_1117 retinoic acid 1.10837 µM -0.28176368279067 0.382351178446595 no 2060 0.389062360004629 3067 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1944 st076371 56.9 µM -0.282984450502068 0.381832051125374 no 2061 0.388594378364642 2892 24208455 SGTC_542 3381-0244 89.3 µM -0.283685417471738 0.381534063249161 no 2062 0.388325735495745 3078 1112843 SGTC_981 1488-1094 54.9 µM -0.286027653878669 0.380538865894279 no 2063 0.387428470614585 2863 3449522 SGTC_1833 st055984 71 µM -0.286291346239291 0.380426874497295 no 2064 0.387327492787656 2939 676288 SGTC_3343 9148379 18.9835 µM -0.287454163965688 0.379933139941564 no 2065 0.386882296696482 3065 1955036 SGTC_807 1315-0151 48 µM -0.287803250439898 0.379784955324637 no 2066 0.386748674552712 3152 4011080 SGTC_2624 nerol 100 µM -0.288388620635532 0.379536509647596 no 2067 0.386524638658775 2893 637566 A natural product oil. SGTC_1512 0259-0544 12.2 µM -0.289650301821002 0.379001189981789 no 2068 0.386041890230128 2937 18476 SGTC_2809 7964133 12.99 µM -0.289768746689264 0.378950946815002 no 2069 0.385996579527413 2962 1253665 SGTC_1430 4049-0248 69.1 µM -0.290003605143369 0.378851328180846 no 2070 0.385906739781976 3044 22774488 SGTC_370 0180-0345 38.7 µM -0.290896600194329 0.378472624846605 no 2071 0.385565200792364 2840 3989527 SGTC_1052 3253-3998 198 µM -0.290987031803172 0.37843428090884 no 2072 0.385530618846226 2857 5450317 SGTC_2394 5221648 200 µM -0.291415182054282 0.37825275702742 no 2073 0.385366902291871 3048 788586 SGTC_3057 9095946 49.47 µM -0.292354521067779 0.377854597417967 no 2074 0.385007788430547 2880 24540043 SGTC_2568 diosmetin 100 µM -0.293842379655987 0.377224201278058 no 2075 0.384439174779132 3094 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2680 butyl paraben 22.24 µM -0.294754566949873 0.37683787497819 no 2076 0.384090687762493 2923 7184 An antifungal and steroid mimetic. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.294852990835572 0.376796198208226 no 2077 0.384053092037465 3067 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3302 9125395 16.351 µM -0.295902347759524 0.376351946149719 no 2078 0.38365232903219 2970 17599668 SGTC_1472 k841-0093 193 µM -0.296292799369443 0.376186687697544 no 2079 0.383503242242456 3051 X1472 SGTC_336 4111-0029 111 µM -0.29778851303379 0.37555383788595 no 2080 0.382932291154614 2968 3131175 SGTC_1964 st076914 61 µM -0.298269966606687 0.375350201703104 no 2081 0.382748562392905 2900 24208661 SGTC_1552 6-methylflavone 10.6 µM -0.300270964588485 0.374504229893351 no 2082 0.381985239420056 2970 689013 SGTC_2683 piperine 63.03 µM -0.300387908179692 0.374454807707362 no 2083 0.381940642969443 2943 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_156 3474-0145 5.642 µM -0.300975912369875 0.374206339237718 no 2084 0.381716431263318 2890 2265471 SGTC_1199 1638-0010 4.46 µM -0.301006249880487 0.374193521162428 no 2085 0.381704864351737 2922 3111136 SGTC_621 3584-0052 32.1 µM -0.301402110117417 0.374026276739818 no 2086 0.381553942721996 3046 2273927 SGTC_508 roscovitine 141 µM -0.301464339915632 0.373999987831999 no 2087 0.381530219262088 2927 160355 A CDKinase inhibitor. SGTC_1954 st077032 68.9 µM -0.302146439210942 0.373711874196865 no 2088 0.38127021619066 3006 698907 SGTC_55 0767-0285 6.563 µM -0.302315792848296 0.373640351416417 no 2089 0.381205670155068 3050 3116166 SGTC_2367 9070478 135.38 µM -0.3024440699193 0.373586179315817 no 2090 0.381156781899439 2902 572802 SGTC_2206 7254556 146.969 µM -0.303241753919007 0.373249369146966 no 2091 0.380852815533555 2983 4398905 SGTC_1594 piperine 70.1 µM -0.303487345816934 0.373145691114708 no 2092 0.380759244801179 2925 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2180 6301957 200 µM -0.304002262277181 0.372928345994152 no 2093 0.380563083815391 3067 845462 SGTC_265 mycophenolic acid 32.932 µM -0.304738989139301 0.372617445522376 no 2094 0.380282476027089 3190 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1350 1495-0454 146 µM -0.305527732736049 0.372284685837043 no 2095 0.379982125698624 3107 1069057 SGTC_2805 7950783 58.44 µM -0.305656294596313 0.372230456449628 no 2096 0.379933176724159 3067 1178958 YDL195W SEC31 SGTC_2238 6671620 73.2395 µM -0.307198936822696 0.371579943915155 no 2097 0.379345977361591 2875 729941 SGTC_3333 9141820 12.094 µM -0.308118944814805 0.371192162658617 no 2098 0.378995913086755 2970 1939433 SGTC_350 k064-0020 19.8 µM -0.308667829113177 0.370960871426978 no 2099 0.378787109113589 3151 2790705 SGTC_2119 5528445 120.635 µM -0.310371291360664 0.370243356297172 no 2100 0.378139311544927 3090 791935 SGTC_1133 3473-0247 50 µM -0.310992929217027 0.369981628547708 no 2101 0.377902998481922 3008 711311 SGTC_1822 st052468 42 µM -0.311048475817082 0.369958244730182 no 2102 0.377881884893441 3007 2873678 SGTC_1845 st056753 3.01 µM -0.31147633700686 0.3697781413113 no 2103 0.377719264576928 2899 5375839 SGTC_2219 9098279 200 µM -0.312074659498952 0.369526332003704 no 2104 0.377491892139689 3033 902349 SGTC_1638 st008370 60.6 µM -0.312735577051871 0.369248244054467 no 2105 0.377240781892972 2933 24207134 SGTC_2787 5284540 71.43 µM -0.314469910025456 0.368518831000436 no 2106 0.376582083221593 3006 736958 SGTC_1159 4092-0538 61.2 µM -0.314734462083572 0.368407609193564 no 2107 0.376481638027591 2975 717301 SGTC_799 1310-0557 151 µM -0.315288816421695 0.368174585759946 no 2108 0.376271187759183 3104 5354492 SGTC_1020 4335-0961 93.3 µM -0.315386693146403 0.368133448209159 no 2109 0.376234034507629 2917 669075 SGTC_1753 st043925 64 µM -0.315479354558836 0.368094504045476 no 2110 0.376198862005308 3073 670181 SGTC_225 nsc-122657 1.016 µM -0.316649030233066 0.367603024061427 no 2111 0.375754963956404 3081 275685 SGTC_400 oxethazaine 37.5 µM -0.317152655007314 0.36739147527412 no 2112 0.375563886308203 3030 4621 A local anesthetic. SGTC_1340 1486-1359 257 µM -0.317230970089595 0.367358582450785 no 2113 0.375534175932064 2974 4309068 SGTC_1308 1187-1617 41.4 µM -0.318269289493912 0.366922573898641 no 2114 0.375140338749526 2956 2882570 SGTC_811 0416-0114 265 µM -0.321115375573144 0.36572833372615 no 2115 0.374061479411028 3066 6612453 SGTC_2029 5175081 200 µM -0.321291485026661 0.365654479407029 no 2116 0.373994754301249 2954 1380876 SGTC_2553 4-methylesculetin 85.09 µM -0.321571233963547 0.36553717244981 no 2117 0.373888769579275 3021 5319502 SGTC_666 0272-0154 136 µM -0.321769585283054 0.365454005526152 no 2118 0.373813628655174 3013 6870312 SGTC_2939 9044578 71.43 µM -0.322017198456349 0.365350192427933 no 2119 0.373719832719068 2933 2653634 SGTC_3056 9094900 49.47 µM -0.323111091616273 0.364891690233244 no 2120 0.373305555265742 3010 25236784 SGTC_2855 9016525 58.44 µM -0.323228956626194 0.36484229896567 no 2121 0.373260926348396 2939 43811474 SGTC_2423 st077119 87.2 µM -0.323583391323095 0.364693786817089 no 2122 0.373126731907106 2982 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2721 ifenprodil 61.44 µM -0.324248020818153 0.364415354283639 no 2123 0.372875134431076 3111 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3248 9135562 49.47 µM -0.324401668699227 0.364350996912486 no 2124 0.372816978279506 3030 17650701 SGTC_710 3448-4187 58 µM -0.324774718534695 0.36419475615656 no 2125 0.372675789941197 3017 3946412 SGTC_2067 5224629 34.075 µM -0.325330427720219 0.3639620558533 no 2126 0.372465502160382 3114 2835000 SGTC_2310 7668677 200 µM -0.325588008048644 0.363854212450158 no 2127 0.372368043212734 3195 2197143 SGTC_2456 5770359 74.46 µM -0.326804180200841 0.363345172829837 no 2128 0.371907998773959 3129 3118787 SGTC_1553 gossypol 38.6 µM -0.32767152655177 0.362982284646297 no 2129 0.371580017173216 2959 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1610 st001799 48.1 µM -0.327960529835286 0.362861396149788 no 2130 0.371470753078484 2927 621897 SGTC_3145 9085516 49.47 µM -0.328043026300078 0.362826890835386 no 2131 0.371439565361692 3081 25236195 SGTC_1933 st074711 15.9 µM -0.328245103069702 0.362742374071362 no 2132 0.371363173980779 2967 17250958 SGTC_1389 3405-0187 19 µM -0.328278521946013 0.362728397575669 no 2133 0.371350541081597 3013 799890 SGTC_1150 3909-7983 10.9 µM -0.329562244734715 0.362191655590398 no 2134 0.370865377235659 3011 23965914 SGTC_2066 5222451 176 µM -0.329724567108699 0.362123805662276 no 2135 0.370804044519944 2981 2281147 SGTC_25 0118-0223 35.662 µM -0.329878331482177 0.36205953693042 no 2136 0.370745948430382 3130 5333628 SGTC_2842 9000675 19.48 µM -0.330056685525341 0.361984995352186 no 2137 0.370678565429838 3038 2989072 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.33071155621306 0.361711342552261 no 2138 0.370431186222916 3084 7104 SGTC_475 α-linolenic acid 10 µM -0.331491127599974 0.361385672883512 no 2139 0.370136770833407 3214 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2619 obliquin 87.91 µM -0.331518132427573 0.361374393285965 no 2140 0.370126573467353 2962 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1928 4'-methoxychalcone 40.3 µM -0.331532129259051 0.361368547022178 no 2141 0.370121288121849 3198 641818 SGTC_3009 9080819 71.4286 µM -0.333283993731411 0.360637075847946 no 2142 0.3694599602731 3062 17027216 SGTC_1447 4239-0816 81.9 µM -0.333417862456757 0.36058120140317 no 2143 0.369409440757777 2996 1341554 SGTC_1613 st002381 52.1 µM -0.333636565117483 0.360489925174106 no 2144 0.369326911377248 3031 551167 SGTC_2242 6630449 61.2675 µM -0.33571347685463 0.359623516513691 no 2145 0.36854347100859 3129 691249 YDR170C SEC7 SGTC_771 0250-0039 27.3 µM -0.336116821218804 0.359455340042955 no 2146 0.368391387059375 3005 3005115 SGTC_2256 7954252 200 µM -0.338616072691259 0.358413872522358 no 2147 0.367449486475804 3066 2972920 SGTC_830 4076-0286 57.8 µM -0.340080325411063 0.357804189489919 no 2148 0.366898018874708 3004 6866659 SGTC_1210 3013-0140 750 nM -0.34147014574616 0.357225833835041 no 2149 0.366374837983 3130 905973 SGTC_2023 5144124 124 µM -0.342882517736388 0.356638429459814 no 2150 0.36584342210899 2996 2830192 SGTC_256 clotrimazole 625 nM -0.343336757894543 0.356449583502058 no 2151 0.365672565375698 3084 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1931 st074438 57.1 µM -0.344709327303001 0.35587916502633 no 2152 0.365156452644157 3009 2787313 SGTC_219 mitoxanthrone 164.414 µM -0.345239296633805 0.355659004253234 no 2153 0.364957239175423 3056 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1421 4029-0249 71.4 µM -0.346318616355183 0.355210780322639 no 2154 0.364551639717934 3159 2894095 SGTC_2727 riluzole 51.77 µM -0.349201293073087 0.354014634633882 no 2155 0.363469097751921 3055 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1991 st073000 8.92 µM -0.349327913559722 0.353962127299441 no 2156 0.363421572418549 3211 4301969 YIL048W NEO1 SGTC_1879 gemcitabine 100 µM -0.349894914429055 0.35372703588209 no 2157 0.363208781895574 3031 60750 A nucleoside analog which inhibits DNA replication. SGTC_3140 9094243 49.47 µM -0.350281451299287 0.353566800894709 no 2158 0.363063742144225 3102 19291112 SGTC_1878 temozolomide 1 mM -0.350325518043965 0.353548535114122 no 2159 0.363047208280741 3142 5394 DNA alkylating agent. SGTC_1107 amlodipine 47 µM -0.351051191391552 0.353247790149193 no 2160 0.362774972027987 3087 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_929 2805-0021 398 µM -0.351124206059645 0.353217535331961 no 2161 0.362747584423111 3102 3098024 SGTC_1250 0485-0349 40.2 µM -0.352440620471469 0.352672216884042 no 2162 0.362253921503509 3039 6842794 YDL195W SEC31 SGTC_1136 pergolide 1.05886 µM -0.35264549925331 0.35258737400072 no 2163 0.362177111363954 3004 47811 A dopamine receptor agonist. SGTC_551 k048-0028 34.9 µM -0.352705067996883 0.352562707209673 no 2164 0.36215477976791 3164 6836383 SGTC_2475 5812728 15.03 µM -0.353383374411737 0.352281871392898 no 2165 0.361900524065226 2995 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2305 7443522 69.23 µM -0.353741458957963 0.352133647902999 no 2166 0.361766324579547 3020 5415886 SGTC_708 3448-5400 146 µM -0.354032553603661 0.352013170383506 no 2167 0.361657243449869 3134 3462195 SGTC_1932 st074806 40.9 µM -0.35576254730772 0.351297471773479 no 2168 0.361009199660438 3264 17251235 SGTC_1290 0986-0249 10.2 µM -0.356446407349746 0.351014703976181 no 2169 0.360753140239609 3090 53329 SGTC_3244 9134489 49.47 µM -0.357465571851287 0.350593444961492 no 2170 0.360371647776627 3103 16584271 SGTC_1118 chelidonine 707.474 nM -0.357991785458357 0.350376012949006 no 2171 0.360174730489088 3143 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_174 3553-0389 74.3 µM -0.359623993461969 0.349701895028567 no 2172 0.359564169126873 3172 738071 SGTC_95 0471-0001 561.058 µM -0.360328577964117 0.34941104093442 no 2173 0.359300715264821 3047 4015405 SGTC_1131 3454-3128 32.3 µM -0.360391990419204 0.349384868461391 no 2174 0.359277007752013 3182 710982 SGTC_1841 st054148 70 µM -0.36098194207378 0.349141409721549 no 2175 0.35905647317322 3117 675442 SGTC_726 3448-4391 34.2 µM -0.361250404325295 0.349030642405598 no 2176 0.358956132680182 3218 1356692 SGTC_1207 2099-0101 141 µM -0.36246878174976 0.348528102596274 no 2177 0.358500874128471 3140 5837381 SGTC_2997 9067075 71.4286 µM -0.364921845136046 0.347517103074243 no 2178 0.357584873552964 3129 27209819 SGTC_148 3253-0744 288.01 µM -0.366066830703661 0.34704558203084 no 2179 0.357157603748121 3079 6893655 SGTC_499 genistein 192 µM -0.367792779426246 0.34633525977803 no 2180 0.356513876711 3121 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2728 chlorpromazine 9.18 µM -0.370225793009149 0.345334859447741 no 2181 0.355607129907777 3036 2726 A thorazine and dopamine antagonist. SGTC_2601 securinine 100 µM -0.370247068411621 0.345326116233541 no 2182 0.355599204485906 3036 442872 A GABA receptor antagonist. SGTC_1809 st050081 57.6 µM -0.370401466318361 0.345262668251681 no 2183 0.355541690709167 3210 5036894 SGTC_152 4469-0003 551.229 µM -0.370634014732305 0.345167113457098 no 2184 0.35545507179482 3120 697280 SGTC_2221 6807166 181.081 µM -0.37200177639531 0.344605296290894 no 2185 0.354945763372978 3116 674925 SGTC_117 lucigenin 22.078 µM -0.372680442230365 0.344326656887077 no 2186 0.354693147167374 3145 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2621 lithochol-11-enic acid 100 µM -0.373361274958714 0.344047212699243 no 2187 0.354439788581895 3187 6708711 SGTC_197 4544-0043 41.561 µM -0.373505881730238 0.343987870574086 no 2188 0.354385984287508 3050 896523 SGTC_704 1310-0270 142 µM -0.375208455148744 0.343289476648086 no 2189 0.353752721248559 3108 5718033 SGTC_2315 7733312 200 µM -0.375312682714987 0.343246739952879 no 2190 0.353713967485406 3050 726316 SGTC_1143 3454-2408 5.08 µM -0.375603236712014 0.343127613939782 no 2191 0.35360594206655 3134 X1143 SGTC_2178 5812956 200 µM -0.37583492080667 0.343032635528721 no 2192 0.353519812406608 3019 5403383 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.377370460850418 0.342403395011745 no 2193 0.352949157872609 3191 5024745 SGTC_1161 k007-0610 110 µM -0.377784633915647 0.342233748100025 no 2194 0.352795294814008 3194 5843850 SGTC_3304 9125678 46.087 µM -0.377988552690747 0.342150233863263 no 2195 0.352719548932006 3056 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2189 6047310 154.431 µM -0.380106834705138 0.341283156022503 no 2196 0.351933056265522 3052 711535 SGTC_873 0591-4978 488 µM -0.380618622253499 0.341073791078411 no 2197 0.351743130526374 3260 3305145 SGTC_1709 st033179 39.1045 µM -0.38095503213781 0.340936197265112 no 2198 0.351618308058701 3063 573381 SGTC_3129 9127257 49.47 µM -0.381669206751465 0.340644165383464 no 2199 0.351353371744908 3065 837894 SGTC_902 1120-0002 2.07 µM -0.381982838737158 0.340515948848179 no 2200 0.351237046955664 3072 3280475 SGTC_3089 9117425 49.47 µM -0.382182196560383 0.340434458547063 no 2201 0.351163113217861 3135 9401657 SGTC_2566 crystal violet carbinol 226 nM -0.382421854979267 0.34033650467421 no 2202 0.351074241078517 3204 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_137 0438-0332 85.389 µM -0.382999523025507 0.340100442826177 no 2203 0.350860058867002 3182 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2723 salbutamol 83.58 µM -0.384185695233057 0.339615914601364 no 2204 0.350420409928582 3176 9884233 β2-adrenoceptor agonist SGTC_165 k038-0023 64.381 µM -0.384410988860712 0.339523916461272 no 2205 0.350336928564662 3086 46368543 SGTC_88 0180-0332 8.668 µM -0.386160192459786 0.338809958832681 no 2206 0.349689016657005 3067 3101745 SGTC_1395 3486-0190 4.35 µM -0.386232795459216 0.33878033757227 no 2207 0.349662133664545 3252 6748079 SGTC_855 0428-0020 25 µM -0.386364565962027 0.33872657913955 no 2208 0.349613344418278 3105 6812414 SGTC_685 1278-0033 54.9 µM -0.387246784433703 0.338366745003185 no 2209 0.349286758896414 3209 3590572 SGTC_709 3807-1509 243 µM -0.387584694924779 0.338228959101971 no 2210 0.349161698470703 3144 1886677 YPL242C IQG1 SGTC_32 0928-0142 34.1 µM -0.388066747726762 0.338032435434119 no 2211 0.348983319431633 3177 2244242 SGTC_2007 4011539 71.82 µM -0.38915878693511 0.337587395325313 no 2212 0.34857934420984 3069 45595301 SGTC_2215 7188065 200 µM -0.389614078455313 0.337401916825728 no 2213 0.348410970077763 3193 940217 SGTC_1225 1216-0074 20.6 µM -0.390253094472993 0.337141658533777 no 2214 0.348174702049801 3111 4241466 SGTC_441 propafenone 146 µM -0.391791013357081 0.33651561494165 no 2215 0.347606317810589 3056 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2971 9092186 9.93 µM -0.391959826067469 0.336446923582602 no 2216 0.347543948822172 3040 25236400 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.392588591492416 0.336191121509037 no 2217 0.347311683539258 3076 803109 SGTC_1655 st012546 55.1 µM -0.394110872028505 0.335572122864254 no 2218 0.346749592278968 3168 720985 YLR208W SEC13 SGTC_99 0109-0120 622.8 µM -0.395705530286857 0.334924171818104 no 2219 0.346161137626344 3317 759414 SGTC_1163 k060-0048 49.9 µM -0.397273611263307 0.33428749860593 no 2220 0.345582852391231 3111 6809982 SGTC_2143 5623677 140.463 µM -0.398277164970714 0.333880284999431 no 2221 0.345212945440808 3193 5375313 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.398382161889454 0.333837691522086 no 2222 0.345174252421256 3253 16725076 SGTC_2949 9072542 2.23 µM -0.399067802739732 0.333559604321127 no 2223 0.344921622768468 3182 16457352 SGTC_86 0417-1630 471.922 µM -0.399155182744873 0.333524170668594 no 2224 0.344889431895729 3191 3634867 SGTC_506 n9-isopropylolomoucine 153 µM -0.399200248455505 0.333505896556485 no 2225 0.344872830086098 3227 6610355 SGTC_1934 st074720 32.6 µM -0.400027861428738 0.333170370398672 no 2226 0.344567997914581 3061 17250992 SGTC_2106 5357045 167.29 µM -0.400367923485944 0.333032543044084 no 2227 0.34444277312883 3193 668842 SGTC_1737 st035557 69.7 µM -0.40308105281144 0.331933719142983 no 2228 0.343444299334243 3143 5716916 SGTC_1496 4469-0713 57.4 µM -0.40312038902324 0.331917798479847 no 2229 0.343429831007675 3224 746691 SGTC_897 1000-0139 31.4 µM -0.403865009143252 0.331616483416758 no 2230 0.343155994168746 3255 6151020 SGTC_2785 7756463 72.73 µM -0.404290010335421 0.331444552910555 no 2231 0.342999735288968 3084 2201551 SGTC_1071 trifluoperazine 6.31 µM -0.404363888313839 0.331414669844361 no 2232 0.342972575538435 3249 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1366 1683-0113 21.9 µM -0.404529788389276 0.331347568468819 no 2233 0.342911588674527 3119 708623 SGTC_3294 9122953 26.2835 µM -0.404693008925685 0.33128155616623 no 2234 0.34285159083556 3118 16459826 SGTC_628 1636-0253 16 µM -0.404717316784061 0.331271725635452 no 2235 0.342842655908185 3178 4456143 SGTC_2438 5259590 200 µM -0.405570867112276 0.330926608450379 no 2236 0.342528969093986 3205 1201127 SGTC_202 3594-0513 34.79 µM -0.406602021632258 0.330509871894552 no 2237 0.342150156095236 3141 708429 SGTC_384 k007-0144 5.16 µM -0.406975489006697 0.330358988492784 no 2238 0.342012995349292 3161 6824886 SGTC_1666 st014829 29 µM -0.407523214846106 0.330137753348348 no 2239 0.341811873627112 3097 3858230 SGTC_3323 9138564 53.9225 µM -0.408812482939147 0.329617232036119 no 2240 0.341338639201912 3270 43912313 YNL103W MET4 SGTC_2065 5221596 34.26 µM -0.409296912084566 0.329421736747479 no 2241 0.341160890678095 3238 788581 SGTC_2917 7979103 53.79 µM -0.410904911915261 0.32877314987711 no 2242 0.340571130284055 3264 2980565 SGTC_459 nigericin 15.3 µM -0.410984861999103 0.328740915437262 no 2243 0.340541817430594 3259 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_224 benfluorex 43.875 µM -0.411181627996491 0.328661588343028 no 2244 0.340469679359231 3242 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_651 3253-0966 34.4 µM -0.411357867890894 0.328590542993323 no 2245 0.340405071493349 3142 781462 SGTC_3110 9122132 49.47 µM -0.412441259547517 0.32815394526792 no 2246 0.340008013391207 3297 918317 SGTC_2203 7227154 166.4 µM -0.413559950221922 0.327703368571565 no 2247 0.339598204507613 3166 896304 SGTC_185 k048-0037 25.491 µM -0.413741500365579 0.327630268985007 no 2248 0.33953171528334 3248 6827589 SGTC_2873 9040596 71.43 µM -0.413925578923514 0.327556158099312 no 2249 0.339464305175263 3240 6463863 SGTC_898 1000-0849 28.3 µM -0.415359950393168 0.326978906380818 no 2250 0.338939210218285 3216 6751807 SGTC_2512 diallyl trisulfide 49.23 µM -0.415496282930126 0.326924061914938 no 2251 0.33888931784096 3197 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1697 st025554 27.742 µM -0.41639687067666 0.326561863386877 no 2252 0.33855980897419 3109 1269519 SGTC_925 2064-1272 59.6 µM -0.416802181246758 0.326398908821603 no 2253 0.338411553421571 3140 6815817 SGTC_894 0960-0238 55.9 µM -0.41693156671479 0.326346896543649 no 2254 0.338364231741451 3261 6741907 YDL195W SEC31 SGTC_1228 0124-0032 52.5 µM -0.417114706801655 0.326273280964077 no 2255 0.338297254111699 3218 X1228 SGTC_2334 9017922 200 µM -0.419210214453839 0.325431446294618 no 2256 0.337531253848636 3244 3163164 SGTC_2437 5741531 144.16 µM -0.419676141771721 0.325244388667542 no 2257 0.337361028213714 3304 2262990 SGTC_3097 9117246 49.47 µM -0.420666333638253 0.324846998790273 no 2258 0.336999374114644 3191 16423892 SGTC_1295 1013-0063 9.78 µM -0.420884214392844 0.324759584276217 no 2259 0.336919816341385 3278 6826038 SGTC_1680 diphenhydramine 100 µM -0.420912760162488 0.324748132329348 no 2260 0.336909393575408 3154 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_318 1488-0629 67.2 µM -0.422795978029642 0.323992992333958 no 2261 0.33622206117742 3242 3662576 SGTC_3049 9092223 49.47 µM -0.424521648016865 0.323301661753143 no 2262 0.335592710496607 3224 8623917 SGTC_797 k781-0471 270 µM -0.425114298308109 0.323064377238464 no 2263 0.335376677578095 3146 23738129 SGTC_1372 2752-0194 270 µM -0.425504963949189 0.322908002421123 no 2264 0.335234301872639 3204 823334 SGTC_989 1501-0895 10.3 µM -0.426164855764719 0.322643933423153 no 2265 0.334993862090414 3280 2830112 SGTC_2191 5911152 200 µM -0.426922085891902 0.322341022727701 no 2266 0.334718039192052 3210 2875902 SGTC_1530 rhein 70.4 µM -0.428468707875211 0.321722702421929 no 2267 0.334154955553882 3193 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2833 9001315 45.46 µM -0.428554708623777 0.321688334854667 no 2268 0.334123655922362 3094 2989378 SGTC_918 glabranin 770.725 nM -0.428642028500089 0.321653441699391 no 2269 0.334091877379764 3192 124049 Also referred to as licorice root. SGTC_1100 amiodarone 5.07 µM -0.428904852927979 0.321548426153205 no 2270 0.33399623420209 3251 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2815 7968870 71.43 µM -0.429020451034567 0.32150224166476 no 2271 0.333954170862613 3153 2977326 YHR190W ERG9 SGTC_776 4476-4378 112 µM -0.429930113576505 0.321138903848064 no 2272 0.333623239620077 3238 2892008 SGTC_2405 ticlatone 3.52 µM -0.430716915491454 0.320824777099731 no 2273 0.333337108890573 2956 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3340 9146634 11.102 µM -0.431722284815147 0.32042357503023 no 2274 0.332971634393983 3248 4907387 SGTC_2887 9044784 58.44 µM -0.433081839384348 0.319881365701555 no 2275 0.332477657849646 3166 6465546 SGTC_1668 st014914 51.6 µM -0.433653507735702 0.319653491176324 no 2276 0.332270036351117 3253 2839556 SGTC_2079 5212404 121 µM -0.434130817883681 0.319463281208166 no 2277 0.332096723778976 3306 758462 SGTC_1597 7-benzyloxygramine 47.5 µM -0.434817414398379 0.319189753103099 no 2278 0.331847481762811 3196 260807 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.435445196849338 0.318939741606087 no 2279 0.331619655002328 3184 6312947 SGTC_1237 0330-0133 46.1 µM -0.436955629833079 0.318338556177367 no 2280 0.33107176331178 3136 X1237 YHR072W ERG7 SGTC_2122 5258151 111.688 µM -0.437137360600601 0.318266255542072 no 2281 0.331005866969313 3181 2173356 SGTC_1736 st036774 51 µM -0.437876779490519 0.317972153013594 no 2282 0.33073780455999 3378 1272247 SGTC_1191 1487-1166 10.6 µM -0.439657423464541 0.317264376322412 no 2283 0.33009262192195 3264 3955771 SGTC_1960 st011366 51.8 µM -0.440497676406107 0.316930621335492 no 2284 0.329788347412515 3190 3972846 SGTC_703 3875-0075 71.8 µM -0.440962384621876 0.316746099559794 no 2285 0.329620114450871 3187 2850814 SGTC_2798 7813637 45.45 µM -0.44196451182321 0.316348339916132 no 2286 0.329257443240932 3296 956368 SGTC_833 3852-0053 558 µM -0.442548857369969 0.316116502204792 no 2287 0.329046041889684 3328 3123681 SGTC_1289 0976-0073 69.1 µM -0.446211608493688 0.314664963856238 no 2288 0.327722199167354 3280 3391136 SGTC_1775 st081588 35.1725 µM -0.446223515634739 0.31466024973978 no 2289 0.327717899039659 3285 1426443 YGL099W LSG1 SGTC_1659 st012954 42.1 µM -0.447617797061328 0.314108453482939 no 2290 0.32721452836795 3282 24207262 SGTC_1229 0139-0193 12.2 µM -0.449203833215988 0.313481273885734 no 2291 0.326642311275544 3329 3090752 SGTC_905 2-aminofluorene 215 µM -0.45055657879672 0.31294677203745 no 2292 0.326154583762134 3229 1539 An established DNA mutagen. YPR165W RHO1 SGTC_826 1683-5028 118 µM -0.451163977921265 0.312706901998965 no 2293 0.325935684842181 3275 722377 SGTC_585 0kpi-0023 191 µM -0.451348218324048 0.31263415866964 no 2294 0.325869298796811 3282 64601 SGTC_2722 naftopidil 47.16 µM -0.451990926061451 0.312380456600464 no 2295 0.325637759677054 3305 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1901 st060216 58.6 µM -0.45319600246768 0.311905005172759 no 2296 0.325203805368683 3173 688792 SGTC_2404 5161160 200 µM -0.453532996504248 0.311772103397473 no 2297 0.3250824944273 3199 2831543 SGTC_2306 7482397 179.52 µM -0.453762475048454 0.311681616991597 no 2298 0.324999897468058 3331 891448 SGTC_2874 9043904 71.43 µM -0.453822027732374 0.311658136443559 no 2299 0.324978463882127 3238 4463428 SGTC_272 doxorubicin 8.13 µM -0.454096325873994 0.311549995526407 no 2300 0.324879748812084 3277 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2426 5582046 32.21 µM -0.454863912696014 0.311247463975183 no 2301 0.324603573195836 3348 2251934 SGTC_2478 5763493 32.33 µM -0.454896883969834 0.311234471750748 no 2302 0.324591712381301 3181 1365576 YLR208W SEC13 SGTC_2807 7945238 51.95 µM -0.455266947595094 0.31108866550404 no 2303 0.324458600945809 3255 17148797 SGTC_1711 st032263 62.8 µM -0.45582146470478 0.31087023949108 no 2304 0.324259183796749 3245 3958979 SGTC_35 0133-0054 64.071 µM -0.455862349505037 0.310854137477502 no 2305 0.324244482673436 3229 99677 SGTC_1481 3346-2004 36 µM -0.4573136770522 0.310282783445569 no 2306 0.323722800230074 3294 2770522 SGTC_1721 st082152 9.2685 µM -0.457832885125373 0.310078494314708 no 2307 0.323536253920186 3225 5296051 SGTC_1468 k284-1086 134 µM -0.459161342574747 0.309556062489146 no 2308 0.323059154287502 3248 15996457 SGTC_536 3852-0578 10.6 µM -0.460237458956197 0.309133148687482 no 2309 0.322672893191513 3336 2869208 SGTC_298 1391-0729 10 µM -0.462179060527492 0.308370738968889 no 2310 0.321976459018674 3205 3237558 SGTC_1460 k062-0059 9.15 µM -0.464476298978586 0.307469747616851 no 2311 0.321153268199547 3162 1373085 SGTC_3029 9088683 49.47 µM -0.465011557557824 0.307259982328961 no 2312 0.320961589993877 3332 25236615 SGTC_944 3370-0224 231 µM -0.465693493436013 0.306992826233308 no 2313 0.320717455177634 3237 4580514 SGTC_2930 9013230 14.89 µM -0.466276808135441 0.30676438738436 no 2314 0.320508688509222 3313 2995857 SGTC_2943 9068529 45.32 µM -0.466667683186417 0.306611354104882 no 2315 0.320368827207434 3300 3270634 SGTC_2376 9072922 81.32 µM -0.466964586139126 0.306495134797644 no 2316 0.320262607661632 3350 17087968 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.467749827145056 0.30618785488805 no 2317 0.319981752035301 3345 5377381 SGTC_2598 perillyl alcohol 100 µM -0.47092874869521 0.304945276221256 no 2318 0.318845808676334 3356 10819 An apoptosis inducer. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.471168082750411 0.30485181592557 no 2319 0.318760354656079 3248 91467 include heat shock SGTC_1265 0819-1001 68.8 µM -0.472318672466805 0.3044026867813 no 2320 0.318349672158682 3338 3106768 SGTC_2279 7948423 32.93 µM -0.472708053344164 0.304250759891218 no 2321 0.31821074010286 3385 1247112 SGTC_2781 5567276 71.43 µM -0.472996194024421 0.304138356196204 no 2322 0.318107947259584 3352 2853274 SGTC_2665 lovastatin 100 µM -0.473606426085638 0.303900365748914 no 2323 0.317890296076706 3288 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_184 1494-0393 24.714 µM -0.474277650183445 0.303638684378859 no 2324 0.317650963532888 3177 3090647 SGTC_2115 tiliquinol 12.7705 µM -0.475851747974411 0.303025406363518 no 2325 0.317090000107116 3278 71208 A bioactive hydroxyquinoline. SGTC_485 niflumic acid 177 µM -0.476051243299248 0.302947721366242 no 2326 0.317018935647003 3348 4488 A COX2 inhibitor. SGTC_3033 9090887 49.47 µM -0.476340592417391 0.302835062461193 no 2327 0.316915875355817 3253 19325384 SGTC_1459 k035-0031 35.7 µM -0.477039213499049 0.30256312970625 no 2328 0.316667099247593 3190 3877128 YMR208W ERG12 SGTC_1292 0kpi-0043 232 µM -0.477096002482411 0.302541029852275 no 2329 0.316646880564805 3290 3333905 SGTC_2702 st077768 96.8 µM -0.477367295638106 0.30243546409551 no 2330 0.316550299140039 3287 6484119 SGTC_1048 3161-0300 24.5 µM -0.477525318140469 0.302373981897569 no 2331 0.316494048274916 3332 2165101 SGTC_2431 5490079 200 µM -0.478923866264072 0.301830089938083 no 2332 0.315996395822555 3283 5722345 SGTC_1396 3511-0007 98.6 µM -0.478980341445238 0.301808136116405 no 2333 0.315976306967668 3317 X1396 SGTC_2171 5739187 198.077 µM -0.480615426880061 0.301172834324663 no 2334 0.315394924569999 3169 2262761 SGTC_2951 9072950 58.06 µM -0.481144629128666 0.30096734536893 no 2335 0.315206855490693 3342 16488155 SGTC_1607 st000305 50.6 µM -0.48145397213302 0.300847256925442 no 2336 0.315096942653444 3354 5457690 SGTC_1642 st009582 77.7 µM -0.482444129493228 0.300463018463407 no 2337 0.314745239371235 3383 6739311 SGTC_3182 9108849 49.47 µM -0.483441841698248 0.300076072655397 no 2338 0.314391022507734 3346 17133045 SGTC_1378 2093-0007 380 nM -0.484010101045865 0.299855783680327 no 2339 0.314189350236297 3333 3618014 SGTC_956 1185-0240 191 µM -0.48409953500379 0.299821120765505 no 2340 0.314157615642091 3236 1416193 SGTC_470 aa-861 153 µM -0.484170694503262 0.299793541982115 no 2341 0.314132366507263 3277 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_180 1486-1293 102.781 µM -0.485426819151764 0.299306903876185 no 2342 0.313686805987847 3426 4140536 SGTC_2093 5331342 194.4 µM -0.485450658952262 0.299297671510608 no 2343 0.313678352386412 3362 33839 SGTC_121 0557-0495 61.343 µM -0.485890942145454 0.299127187633921 no 2344 0.313522245406929 3302 3104427 SGTC_1738 st035555 74 µM -0.486107242136512 0.299043449369577 no 2345 0.313445566228937 3334 5331140 SGTC_3120 9124077 49.47 µM -0.486613157409633 0.298847631172482 no 2346 0.313266248806061 3337 18774327 YGL155W CDC43 SGTC_1719 st032227 49.2 µM -0.487570678880567 0.29847717508169 no 2347 0.312926984212794 3244 3125804 SGTC_948 3448-0295 75.3 µM -0.48883139998583 0.29798973281229 no 2348 0.312480532864985 3335 678569 SGTC_347 4534-1311 26.2 µM -0.489190684504385 0.29785088634584 no 2349 0.312353352004922 3311 2862016 SGTC_1864 st057645 30.4 µM -0.490148975294875 0.297480696661418 no 2350 0.312014242039148 3372 688666 SGTC_792 4534-1957 155 µM -0.490277822015725 0.297430938937902 no 2351 0.311968659243104 3257 1717904 SGTC_1320 1313-0481 95.3 µM -0.490280924565922 0.297429740849233 no 2352 0.311967561672768 3416 6813365 YLR208W SEC13 SGTC_2089 5281248 129.67 µM -0.491072859468586 0.297123997367926 no 2353 0.311687458296606 3312 2737878 SGTC_3115 9123671 49.47 µM -0.491583739544728 0.2969268374223 no 2354 0.311506820376266 3390 3286988 SGTC_1304 1165-0502 251 µM -0.492790020913445 0.296461544401753 no 2355 0.311080481243534 3260 767425 SGTC_423 5-fluorouracil 457 µM -0.493069374016464 0.296353838565752 no 2356 0.310981784869862 3171 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_394 menadione 8.33 µM -0.49392316603511 0.29602476650152 no 2357 0.310680221617684 3353 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2196 6573537 42.6665 µM -0.494145675845154 0.29593903340667 no 2358 0.31060165101236 3392 2903087 SGTC_1362 1611-0397 101 µM -0.494893307412503 0.295651054287819 no 2359 0.310337717563159 3271 27816 SGTC_1174 0739-0097 51.1 µM -0.495616705274748 0.295372532386977 no 2360 0.310082432183822 3284 728447 SGTC_603 3794-0023 45.9 µM -0.496246876721441 0.29513000285671 no 2361 0.309860120761164 3355 3802260 SGTC_49 0717-0965 32.132 µM -0.498945340526503 0.294092503178986 no 2362 0.308908945607644 3511 5889349 YGL099W LSG1 SGTC_1511 0906-3109 28.5 µM -0.498994150406463 0.294073752389646 no 2363 0.308891752496069 3348 2882180 SGTC_1868 st057644 42.7 µM -0.499301801941938 0.293955577785054 no 2364 0.308783392944709 3256 688665 SGTC_2799 7812892 81.82 µM -0.500355041707849 0.293551175415733 no 2365 0.308412551947932 3398 20205235 SGTC_2906 7926292 26.41 µM -0.500511113143673 0.293491272086499 no 2366 0.308357616509012 3383 2966319 SGTC_2543 pimpinellin 60.67 µM -0.500661675208889 0.293433488729617 no 2367 0.308304624374892 3236 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1643 st009866 20.2 µM -0.501291120558943 0.293191974577872 no 2368 0.30808312676172 3349 3156273 YOR207C RET1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.501582244857658 0.29308030322784 no 2369 0.307980705696131 3307 2374 Ca(2+)-ATPase inhibitor. SGTC_663 1486-0733 13.9 µM -0.501740302776961 0.293019682608454 no 2370 0.307925105262913 3273 722445 YPR165W RHO1 SGTC_348 k064-0012 10.7 µM -0.503245172798602 0.292442805042973 no 2371 0.307395954318881 3292 5066323 SGTC_661 1304-0007 33.6 µM -0.503600203539369 0.292306784405707 no 2372 0.307271174761332 3298 3117130 SGTC_2427 5545055 42.75 µM -0.504347466070493 0.292020586716927 no 2373 0.307008613821447 3296 5372858 SGTC_2173 5763948 167 µM -0.504767572056476 0.291859745602491 no 2374 0.306861047259221 3365 2867177 SGTC_1252 0493-0875 34.8 µM -0.50561376859802 0.291535897465285 no 2375 0.306563906997469 3272 3960963 SGTC_2789 5281112 71.43 µM -0.506775745175575 0.291091470303772 no 2376 0.306156088327524 3305 765948 SGTC_2652 actinonin 100 µM -0.507103725708192 0.290966083189403 no 2377 0.306041020498669 3292 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1281 0884-0031 11.8 µM -0.508006349532047 0.290621140033365 no 2378 0.305724445155218 3326 1548255 SGTC_1339 1486-1321 22.7 µM -0.50821366572463 0.29054193992029 no 2379 0.305651754073564 3307 3469382 SGTC_1062 mesoridazine 14.2 µM -0.509251080113081 0.290145772770521 no 2380 0.305288121533845 3350 4078 A neuroleptic. SGTC_1813 st051246 8.6015 µM -0.509514470083068 0.290045229882287 no 2381 0.305195829136566 3353 5291959 SGTC_1950 st077106 7.18 µM -0.509612729736783 0.290007725767922 no 2382 0.305161401919756 3319 13831864 SGTC_3223 9129970 49.47 µM -0.510229716817269 0.289772283790674 no 2383 0.304945267676212 3313 17248386 SGTC_1031 k035-0009 16 µM -0.510533512601211 0.289656388424055 no 2384 0.304838871197669 3418 5180959 SGTC_913 3487-1245 167 µM -0.511807949721868 0.289170439332853 no 2385 0.30439271302128 3249 4016153 SGTC_125 0133-0007 11.75 µM -0.513515279659683 0.288520027477324 no 2386 0.303795462654109 3441 26541 SGTC_80 0159-0065 512.242 µM -0.515547241695468 0.287746845795872 no 2387 0.30308533321889 3375 1548079 SGTC_2726 cimetidine 79.27 µM -0.516990631858175 0.287198216890658 no 2388 0.302581349229322 3336 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_962 1254-0300 21.5 µM -0.519284221004609 0.286327449441699 no 2389 0.301781277574195 3337 7340576 SGTC_2704 st078022 71.1 µM -0.523499701545151 0.284730307400943 no 2390 0.300313279334296 3442 54697681 SGTC_420 mitomycin C 81.9 mM -0.523572858097048 0.284702627757883 no 2391 0.300287831820718 3315 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2395 5646831 180.19 µM -0.524797335824303 0.28423952296255 no 2392 0.299862041891595 3452 6808628 SGTC_3123 9126162 49.47 µM -0.525021341255868 0.284154841752951 no 2393 0.299784177646873 3343 25239884 SGTC_3031 9088762 49.47 µM -0.525349567852943 0.284030783407512 no 2394 0.299670102684461 3299 205253 SGTC_2194 5927483 104.545 µM -0.525434424160194 0.283998714862801 no 2395 0.299640614123772 3350 760979 SGTC_1633 st005664 67.9 µM -0.525476521211211 0.283982806362289 no 2396 0.299625985393367 3310 2063822 SGTC_813 k007-0158 173 µM -0.525480533706795 0.283981290060089 no 2397 0.299624591067551 3358 6523916 SGTC_1103 duloxetine 36.1 µM -0.525734816568364 0.283885205729298 no 2398 0.299536234809709 3439 60835 A selective serotonin reuptake inhibitor. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.525739603219916 0.283883397175378 no 2399 0.299534571693999 3229 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1298 1079-1278 263 µM -0.525888862764651 0.283827004792183 no 2400 0.299482713764013 3390 2840950 SGTC_2713 st079149 53.4 µM -0.528238180162251 0.282940106453575 no 2401 0.298667016391859 3382 3103253 SGTC_2005 4024620 188 µM -0.528663870948738 0.282779545073631 no 2402 0.298519322113941 3403 236743 SGTC_636 0kpi-0074 126 µM -0.52892922831173 0.282679480153451 no 2403 0.298427272655316 3371 616434 SGTC_868 0527-0199 213 µM -0.528971386492058 0.282663584083355 no 2404 0.298412649650001 3306 2849450 SGTC_1104 tacrolimus 29.8 µM -0.529377022825551 0.282510657702095 no 2405 0.298271967115951 3430 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3079 9117512 49.47 µM -0.532405492864473 0.28137017243185 no 2406 0.297222590820999 3412 7185044 SGTC_3156 9099931 49.47 µM -0.532931946691716 0.281172143219106 no 2407 0.297040344878695 3303 18111053 SGTC_17 0960-0276 49.807 µM -0.532935090706091 0.281170960778785 no 2408 0.297039256648344 3384 6821114 SGTC_641 4092-0595 30 µM -0.533289829126829 0.281037561732883 no 2409 0.296916483578531 3416 786260 SGTC_270 tamoxifen 5.46 µM -0.533604700767093 0.280919180175215 no 2410 0.296807527643344 3517 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1884 5633444 25 µM -0.534024848102287 0.280761255907119 no 2411 0.296662171367624 3441 5724239 SGTC_3147 9097027 49.47 µM -0.534278621879276 0.280665888652732 no 2412 0.296574390316803 3335 25236841 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.535934922702515 0.280043842076077 no 2413 0.296001763782664 3357 689007 SGTC_2457 5731572 11.68 µM -0.536246650844282 0.279926843047478 no 2414 0.295894047983919 3427 2865357 SGTC_1637 st007924 17.4 µM -0.536292042002286 0.27990980863727 no 2415 0.295878364841735 3388 683336 SGTC_3267 9137951 49.47 µM -0.537478476035565 0.279464741622649 no 2416 0.295468574359165 3338 16643986 SGTC_1342 1486-1464 234 µM -0.537804109115116 0.279342647017157 no 2417 0.295356147416905 3400 3253938 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.53823369709355 0.279181614663292 no 2418 0.29520785948777 3352 15053 SGTC_1827 berberine 7.24 µM -0.538383333620809 0.279125533556481 no 2419 0.295156215042758 3297 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_264 promethazine 12.5 mM -0.538591968281422 0.279047350142578 no 2420 0.295084215362552 3490 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_216 k038-0035 28.382 µM -0.538741812414371 0.278991204367425 no 2421 0.295032509245284 3394 4444231 YPR107C YTH1 SGTC_1992 st073643 23.3 µM -0.539040413911771 0.278879336410622 no 2422 0.294929484464641 3395 3161292 SGTC_3273 9137859 49.47 µM -0.540433246257085 0.278357814736249 no 2423 0.294449142585756 3449 2377234 SGTC_1429 4049-0205 9.46 µM -0.540546575368016 0.2783154015565 no 2424 0.294410075009691 3451 22774478 SGTC_3138 9097216 49.47 µM -0.541258276620674 0.278049120902793 no 2425 0.294164787270025 3443 25237486 SGTC_3077 9117319 49.47 µM -0.54201032998552 0.277767877773995 no 2426 0.293905694838577 3433 17154678 SGTC_1287 0971-0001 34.6 µM -0.542530161258839 0.277573559269329 no 2427 0.293726667730931 3442 4665869 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.543271306252086 0.27729662623596 no 2428 0.293471508668266 3444 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2732 terfenadine 20 µM -0.543956849290626 0.277040589545191 no 2429 0.293235583516446 3400 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1026 k007-1105 30.6 µM -0.545168140628959 0.276588479363621 no 2430 0.292818940591611 3436 7066794 SGTC_2695 st077686 51.995 µM -0.546330057971031 0.276155137966006 no 2431 0.292419539086943 3384 2876092 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.546423322351631 0.276120369121593 no 2432 0.292387491048292 3402 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1741 st038134 10.228 µM -0.547224709604233 0.275821701551072 no 2433 0.292112181116575 3533 1272587 SGTC_1725 st036284 20.55 µM -0.547352794830699 0.275773980416154 no 2434 0.292068189686177 3491 707914 SGTC_1185 1319-0113 81.3 µM -0.548857538530291 0.275213657129494 no 2435 0.29155160996405 3435 4672763 SGTC_2481 5478948 45.16 µM -0.549564348432815 0.274950655053771 no 2436 0.291309108712172 3467 77792 SGTC_2365 9042475 200 µM -0.550023314824206 0.274779941227579 no 2437 0.291151691163919 3434 6464479 SGTC_1356 1502-0781 85.8 µM -0.550186623874573 0.274719210578952 no 2438 0.291095688562279 3366 567702 SGTC_2047 4141938 200 µM -0.550408538914372 0.274636696402504 no 2439 0.291019596621491 3367 3807862 SGTC_2649 anisomycin 9.56 µM -0.553431043964849 0.273514063650517 no 2440 0.28998414316967 3435 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1914 st062367 72.6 µM -0.554555434135696 0.27309701789401 no 2441 0.289599389514367 3371 978205 SGTC_980 1473-0395 201 µM -0.554885958082641 0.272974483752971 no 2442 0.289486333539183 3391 768876 SGTC_2265 7929201 200 µM -0.555834687721094 0.27262291557689 no 2443 0.289161935017949 3360 1265108 SGTC_754 3474-0146 171 µM -0.556761001753969 0.272279870871366 no 2444 0.28884536605774 3310 24762078 SGTC_1591 genipin 88.4 µM -0.556864050753301 0.272241721682286 no 2445 0.288810159021051 3465 442424 A DNA cross-linking agent. SGTC_1975 st070967 30.8 µM -0.557181080168488 0.272124372668544 no 2446 0.288701857526214 3487 261391 SGTC_469 w7 172 µM -0.557656818970358 0.271948324280107 no 2447 0.288539374671674 3451 45115570 A P450 inhibitor. SGTC_2341 7987486 176.74 µM -0.558395844849498 0.271674958221287 no 2448 0.288287054779206 3474 1258686 SGTC_2752 diclazuril 33.15 µM -0.55854954991122 0.271618119827962 no 2449 0.288234589522592 3440 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.5602381059617 0.27099410097428 no 2450 0.287658519227981 3406 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1156 4092-0367 4.88 µM -0.561392719671347 0.270567816729512 no 2451 0.287264923000065 3410 1357585 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.562372162250425 0.270206468582047 no 2452 0.28693124077648 3406 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2422 chlorphenesin carbamate 384.24 µM -0.563069703705315 0.269949270131471 no 2453 0.286693710291226 3377 2724 A muscle relaxant with antifungal properties. SGTC_2040 5100729 123 µM -0.565226444400062 0.269154809623211 no 2454 0.2859598760062 3405 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2883 9059145 45.46 µM -0.566566920157376 0.268661621603288 no 2455 0.285504227468763 3384 16476510 SGTC_1001 4048-4355 44.4 µM -0.566650853860068 0.268630755817302 no 2456 0.285475708601293 3444 21824233 SGTC_608 k048-0125 159 µM -0.567688018954395 0.268249495770234 no 2457 0.285123414179711 3490 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1221 2958-7315 257 µM -0.568512029853071 0.267946785012633 no 2458 0.284843669764039 3467 4562705 SGTC_482 fipronil 114 µM -0.568685422924922 0.267883108803243 no 2459 0.284784821030169 3488 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_43 0570-0105 72.5 µM -0.569968719477384 0.267412072953909 no 2460 0.284349457126641 3489 1114046 YDL195W SEC31 SGTC_1720 st037298 9.481 µM -0.571651536730169 0.26679502620649 no 2461 0.283779036579856 3451 597396 SGTC_2952 9073731 13.78 µM -0.571967553450317 0.266679231123963 no 2462 0.283671978283687 3408 16457353 SGTC_3191 9110352 49.47 µM -0.572566402806115 0.266459870007517 no 2463 0.283469156681991 3469 17122424 SGTC_2151 5563267 85.4165 µM -0.5728675278461 0.266349601097731 no 2464 0.283367196262192 3409 5310824 SGTC_1797 st048695 56.8 µM -0.574049657095591 0.265916940830919 no 2465 0.282967099433639 3465 592262 YIL048W NEO1 SGTC_1033 k072-0102 21.3 µM -0.57409970263034 0.265898631984648 no 2466 0.282950167288683 3491 5965931 SGTC_3159 9100096 49.47 µM -0.575899516125567 0.265240606310472 no 2467 0.282341551350247 3444 25236875 SGTC_2964 9083345 53.42 µM -0.576451313863655 0.265039030534272 no 2468 0.28215508440865 3400 17741579 SGTC_2622 2-methoxyxanthone 59.94 µM -0.576647859406192 0.264967249802723 no 2469 0.282088680831625 3433 71034 A hepatoprotective. SGTC_2592 piperlongumine 83.33 µM -0.579121482248688 0.264064699112177 no 2470 0.281253602906948 3419 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2244 6635614 200 µM -0.579178143859307 0.264044043358481 no 2471 0.281234488331935 3302 836499 SGTC_602 3130-1533 38.1 µM -0.579524181344677 0.263917914706817 no 2472 0.281117767540235 3514 720941 SGTC_177 1327-0068 8.361 µM -0.58061842345111 0.263519272029713 no 2473 0.280748826319436 3478 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1182 1222-0449 220 µM -0.580876304423924 0.263425368333949 no 2474 0.280661911735078 3467 658318 SGTC_77 0828-0286 12.516 µM -0.582604745999403 0.262796422110315 no 2475 0.280079704869807 3476 745345 SGTC_605 1315-0399 119 µM -0.583822071091597 0.262353922606065 no 2476 0.279670013684514 3558 24020461 SGTC_324 1315-0088 19.6 µM -0.584941326097283 0.261947408691571 no 2477 0.279293584847648 3464 6787421 SGTC_3085 9117376 49.47 µM -0.585111646964458 0.261885576402001 no 2478 0.279236323972515 3502 16480349 SGTC_2897 9048598 12.99 µM -0.585346492568494 0.261800331707266 no 2479 0.279157379618292 3414 6467404 SGTC_1102 cgs 12066b 26.1 µM -0.585455757887062 0.261760675230666 no 2480 0.279120653312858 3453 6438352 A 5-HT1B full agonist. SGTC_171 k064-0041 9.68 µM -0.587772478211361 0.260920576627197 no 2481 0.278342509723301 3415 53325 SGTC_1006 4099-6547 255 µM -0.588185090362481 0.26077109912741 no 2482 0.278204031928408 3503 3146833 SGTC_231 b-estradiol 524 µM -0.589695577073796 0.260224269416024 no 2483 0.277697380499796 3422 450 A steroid. SGTC_1344 1488-0097 29.1 µM -0.589984852607095 0.260119612716391 no 2484 0.277600402382194 3504 747966 SGTC_484 loperamide 105 µM -0.591551028027495 0.259553364698093 no 2485 0.277075637715058 3460 3955 An opioid-receptor agonist. SGTC_1951 sophoraflavanone G 9.2 µM -0.59222535427445 0.259309759373727 no 2486 0.276849846740762 3460 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_260 nsc-65238 3.989 µM -0.593544598326733 0.258833514629564 no 2487 0.276408372671048 3470 3246252 SGTC_432 NS 1619 61.3 µM -0.59365742714911 0.258792804645772 no 2488 0.276370631475829 3518 4552 A K+/calcium channel activator. SGTC_639 0833-0042 114 µM -0.594234780871473 0.258584540413783 no 2489 0.276177546460418 3468 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3349 9149703 23.001 µM -0.594750402805966 0.258398617591249 no 2490 0.276005162459711 3505 4910494 SGTC_2323 6148992 148.28 µM -0.595568539765937 0.258103756173349 no 2491 0.275731749368546 3427 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_322 k048-0136 19.3 µM -0.595577995585632 0.258100349259991 no 2492 0.275728590107668 3522 6823282 SGTC_747 3448-8087 38.7 µM -0.595928990511713 0.257973902974107 no 2493 0.275611332637237 3467 5168703 SGTC_2528 xanthyletin 44.79 µM -0.595953485940976 0.257965079670046 no 2494 0.275603150322985 3480 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3130 9127414 49.47 µM -0.596919868217743 0.257617111739886 no 2495 0.275280440811146 3519 1494646 SGTC_1548 st061468 90.8 µM -0.598500077236482 0.257048647091392 no 2496 0.274753153700706 3481 390799 SGTC_2966 9084041 48.03 µM -0.599446600249705 0.256708457460784 no 2497 0.274437554771219 3370 17741380 SGTC_2864 9034755 47.6 µM -0.601282833296911 0.256049166415338 no 2498 0.273825810721558 3526 4930451 SGTC_334 1502-1024 68.5 µM -0.601477993991325 0.255979146825115 no 2499 0.27376083227926 3537 3296216 SGTC_288 1315-0019 35.1 µM -0.603129307540998 0.255387090047229 no 2500 0.273211335511639 3546 6811474 SGTC_2895 9054447 58.44 µM -0.604708040416143 0.254821726008239 no 2501 0.272686502391878 3522 2697450 SGTC_1706 st031321 9.9705 µM -0.604859572268068 0.254767495032458 no 2502 0.272636153551556 3529 6103185 SGTC_2038 4100038 30.985 µM -0.605586796886344 0.254507316362435 no 2503 0.272394585964612 3514 3596803 SGTC_3166 9102297 49.47 µM -0.606608849371632 0.254141892767772 no 2504 0.272055263024855 3492 25237072 SGTC_1704 st028805 70.8 µM -0.607098277029455 0.253967000795909 no 2505 0.271892846772297 3502 2876101 SGTC_2284 7945075 39.21 µM -0.607226643722172 0.253921140726658 no 2506 0.271850256354449 3547 1245402 SGTC_2264 7948757 110.76 µM -0.607236706499399 0.253917545899457 no 2507 0.271846917794684 3487 2971411 SGTC_1433 4060-0023 7.6 µM -0.607291043719649 0.253898134928826 no 2508 0.271828890513936 3535 3840627 SGTC_1564 D-Arginine 115 µM -0.608379289422349 0.253509543255637 no 2509 0.271467972121722 3474 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2896 9052656 71.43 µM -0.61059227858719 0.252720292143666 no 2510 0.270734767864734 3506 6469436 SGTC_544 k015-0020 52.4 µM -0.611229054780488 0.252493429181694 no 2511 0.270523975460324 3526 3008304 SGTC_362 0310-0100 9.03 µM -0.611595095666396 0.252363069127297 no 2512 0.270402841851965 3544 790235 SGTC_1217 1183-1422 255 µM -0.611645545675634 0.252345104883998 no 2513 0.270386148597922 3550 2849664 SGTC_3222 9128301 49.47 µM -0.611864056648912 0.252267305262805 no 2514 0.270313852096996 3508 4911358 SGTC_3286 9117135 37.221 µM -0.615515758633336 0.250969011003663 no 2515 0.269107082753224 3456 3438150 SGTC_1238 0333-0287 48.8 µM -0.61663035530598 0.250573442534157 no 2516 0.268739283854184 3523 7226 SGTC_1373 2887-0003 58.5 µM -0.616967953943037 0.250453694558322 no 2517 0.268627931605209 3509 776948 SGTC_624 k048-0052 28 µM -0.617492047622562 0.25026785593319 no 2518 0.268455112490318 3495 6835531 SGTC_2561 acetosyringone 100 µM -0.617817689809802 0.25015242315602 no 2519 0.268347760626197 3490 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2892 9047358 58.44 µM -0.618020254861577 0.250080632684198 no 2520 0.26828099351474 3496 6466771 SGTC_2803 7707263 71.43 µM -0.618818611062296 0.249797796123039 no 2521 0.268017930127953 3496 2199229 SGTC_37 0566-0070 1.56 µM -0.618892494553982 0.249771629737799 no 2522 0.267993591620016 3545 1626686 SGTC_2684 capsaicin 100 µM -0.619912941932807 0.24941037965961 no 2523 0.267657552361762 3556 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2322 7413319 38.22 µM -0.620961522562952 0.249039459578174 no 2524 0.267312470038438 3562 1840400 SGTC_677 0929-0063 136 µM -0.6220111894867 0.24866844939186 no 2525 0.266967255190585 3523 1539583 SGTC_2836 9010338 19.48 µM -0.62207193025304 0.24864698926865 no 2526 0.266947285639018 3451 2994051 SGTC_340 k038-0059 454 µM -0.62223253948922 0.248590249693086 no 2527 0.266894486278735 3537 23733424 SGTC_128 0906-2981 13.371 µM -0.622498814035162 0.248496196175383 no 2528 0.26680696168271 3542 6740226 SGTC_337 1315-0038 354 µM -0.622622374859373 0.248452558452342 no 2529 0.266766352096265 3538 1626437 SGTC_328 k915-0120 63.5 µM -0.623258317640662 0.248228028457 no 2530 0.266557392124335 3542 6624543 SGTC_3070 9117005 49.47 µM -0.62403495577076 0.247953970494464 no 2531 0.266302314373848 3585 8779016 SGTC_667 1498-1044 59 µM -0.624271333172494 0.247870590339218 no 2532 0.266224703497296 3542 6739982 SGTC_556 4058-0063 51.5 µM -0.626335300084079 0.247143179547181 no 2533 0.265547518608973 3588 6615692 SGTC_1049 3226-0134 66 µM -0.626368412374084 0.24713151898416 no 2534 0.265536661634787 3580 5702385 SGTC_3308 9128332 17.569 µM -0.627282093300055 0.246809880428641 no 2535 0.265237169573373 3581 17332805 YDL196W YDL196W SGTC_1917 st066507 28.5 µM -0.629854643316838 0.245905483483414 no 2536 0.264394845257301 3493 3156428 SGTC_1681 tripelennamine 100 µM -0.630099840943145 0.245819375571681 no 2537 0.264314631877944 3571 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2049 5262831 67.185 µM -0.630658519935622 0.245623240496374 no 2538 0.264131913224227 3568 763417 SGTC_2700 st077718 96.8 µM -0.632603320527867 0.244941136637033 no 2539 0.26349635907778 3531 904970 SGTC_3135 9127742 49.47 µM -0.632927520101788 0.244827528660464 no 2540 0.263390487723239 3518 3643468 SGTC_471 1-acyl-paf 4 µM -0.634536211047131 0.244264221213333 no 2541 0.262865471368823 3526 16759367 SGTC_285 1486-1325 46 µM -0.634820644349264 0.24416469533159 no 2542 0.262772698716768 3593 22310230 SGTC_1032 k061-1018 98.7 µM -0.635996156258555 0.243753604708158 no 2543 0.262389463664641 3653 4005393 SGTC_2664 lyso-paf C-16 73.48 µM -0.636016296095947 0.243746564822252 no 2544 0.262382900260973 3571 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.638313433063622 0.242944320608761 no 2545 0.261634834691607 3531 6708514 SGTC_787 4152-0075 138 µM -0.639400890361239 0.242565039528807 no 2546 0.261281084957708 3556 9566539 SGTC_1554 st069299 38.7 µM -0.63955700171559 0.242510617670656 no 2547 0.261230322129044 3574 24207999 SGTC_2541 muurolladie-3-one 83.07 µM -0.639900588649691 0.242390863394826 no 2548 0.261118615599426 3605 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2962 9082311 13.18 µM -0.640524211990578 0.242173586711294 no 2549 0.26091592674544 3542 16459453 SGTC_2587 piperic acid 92.2 µM -0.640832188678065 0.24206632347642 no 2550 0.260815858613198 3521 5370536 SGTC_2936 9038235 15.59 µM -0.64119785114591 0.241939002689776 no 2551 0.260697072794981 3584 4749415 SGTC_226 1,3-diallylurea 8.28947 mM -0.642960979841922 0.241325605372328 no 2552 0.260124709694631 3546 74537 YKL182W FAS1 SGTC_1774 st048371 48.465 µM -0.645758517788999 0.24035407079739 no 2553 0.259217878301352 3556 4242727 SGTC_3158 9100007 49.47 µM -0.646351798302816 0.240148309341768 no 2554 0.259025774635309 3572 19297233 SGTC_1093 fluphenazine 7.97 µM -0.647320608889918 0.239812513109803 no 2555 0.258712233041422 3639 6602611 An atypical antipsychotic. SGTC_377 3970-0964 33.1 µM -0.647554256279979 0.239731567716084 no 2556 0.258636645841949 3586 16481235 SGTC_1999 st074831 12.5 µM -0.64866929346425 0.23934547683548 no 2557 0.258276078034131 3566 17112523 SGTC_2373 9071805 200 µM -0.648715122827079 0.239329615308299 no 2558 0.258261263841663 3615 10149009 SGTC_3 0833-0587 95.581 µM -0.649290537218489 0.239130513450866 no 2559 0.258075300496726 3539 5382644 SGTC_1180 1193-0155 285 µM -0.649318503668074 0.239120838954615 no 2560 0.258066264024576 3591 2921347 SGTC_479 n-linoleoylglycine 10 µM -0.649366644484651 0.239104185995687 no 2561 0.258050709229249 3570 6433346 An anti-infammatory. SGTC_1349 flufenamic acid 69 µM -0.650055252827331 0.238866050740473 no 2562 0.257828265990297 3568 3371 A non-steroidal anti-inflammatory. SGTC_1014 4130-3005 69.3 µM -0.650410007740892 0.238743419670895 no 2563 0.257713707285902 3615 743608 SGTC_3298 9116858 71.43 µM -0.650617442374867 0.238671729984207 no 2564 0.257646734009138 3612 2506942 SGTC_3109 9122853 49.47 µM -0.652918758208724 0.237877182954527 no 2565 0.256904327572411 3620 1234709 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.653375911118436 0.237719520248157 no 2566 0.256756982293177 3576 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3146 9095609 49.47 µM -0.653998033582533 0.237505055028815 no 2567 0.256556536251917 3604 17173999 SGTC_217 ketoconazole 989 nM -0.654157029983586 0.237450261003041 no 2568 0.25650532115632 3558 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_93 0109-0045 59.227 µM -0.654499389889942 0.237332299017886 no 2569 0.256395060043883 3666 88733 SGTC_1193 1488-0126 41.5 µM -0.655631177546801 0.236942564500484 no 2570 0.256030730123339 3628 1384710 SGTC_448 monastrol 171 µM -0.65617768707934 0.23675449831193 no 2571 0.25585490183262 3560 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2529 gangaleoidin 93.61 µM -0.657776212275873 0.236204881474296 no 2572 0.25534097095295 3644 4565183 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.658512835874177 0.23595184678421 no 2573 0.255104325891634 3613 6708561 SGTC_1 0258-0098 57.368 µM -0.659188065230539 0.23572003268391 no 2574 0.254887504937174 3527 6790032 YDR047W HEM12 SGTC_1956 st077085 54 µM -0.660179141571223 0.235380012211645 no 2575 0.254569438023585 3598 24208685 SGTC_2314 7727897 200 µM -0.660212017506064 0.235368737710457 no 2576 0.254558890687846 3594 900724 SGTC_619 1652-1634 108 µM -0.661029019842923 0.235088649999747 no 2577 0.254296851603004 3557 5400454 SGTC_3335 9143315 29.6265 µM -0.661053550741932 0.235080243075672 no 2578 0.254288985937228 3568 4899691 SGTC_3099 9120367 49.47 µM -0.662479933817437 0.234591696505279 no 2579 0.25383184533374 3641 24824940 SGTC_3307 9126885 69.2785 µM -0.662593933839029 0.234552674917594 no 2580 0.253795328165603 3603 24824909 SGTC_3102 9121669 49.47 µM -0.664036972980935 0.234059040949226 no 2581 0.253333323769406 3624 41905072 SGTC_1820 st053765 18.6 µM -0.665518799119284 0.233552738108097 no 2582 0.252859361802317 3604 3690829 SGTC_927 2425-1185 123 µM -0.666221690103782 0.233312790424626 no 2583 0.252634705503843 3603 730375 SGTC_1187 1391-0724 117 µM -0.666515143828011 0.23321265387271 no 2584 0.252540943660173 3657 6997986 SGTC_2516 gossypol 71.55 µM -0.668237747894832 0.232625323113172 no 2585 0.251990921727405 3642 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_170 4197-0004 226 µM -0.66836563523185 0.232581752077537 no 2586 0.2519501129338 3619 218692 SGTC_181 1447-1644 8.07 µM -0.668405917029226 0.232568029065576 no 2587 0.251937259752112 3588 534600 SGTC_1274 0865-0114 173 µM -0.668443642525691 0.232555177330344 no 2588 0.251925222552911 3627 870624 SGTC_1626 st003712 1.76 µM -0.6690761210857 0.232339773187001 no 2589 0.251723460733347 3598 24207035 SGTC_3275 9138069 49.47 µM -0.67098452761984 0.231690497591305 no 2590 0.251115193105245 3645 17617007 SGTC_1387 3342-1166 1.8 µM -0.671172765630174 0.231626510326742 no 2591 0.251055238040212 3610 3418228 SGTC_1734 st037168 69.4 µM -0.671447540654689 0.231533124440472 no 2592 0.250967733955527 3612 708907 SGTC_2245 6637752 200 µM -0.672634535472508 0.231129949993599 no 2593 0.250589912446786 3599 681890 SGTC_1166 k206-0078 225 µM -0.673769818206585 0.230744706884151 no 2594 0.250228833055076 3640 5404595 SGTC_92 0063-0024 660.874 µM -0.673903633147449 0.230699322204086 no 2595 0.250186291077035 3677 3594437 SGTC_1874 staurosporine 7.6 µM -0.674812930366642 0.230391057037873 no 2596 0.249897312107275 3645 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1982 st072467 71.9 µM -0.676099779790117 0.229955189949769 no 2597 0.24948864823575 3615 3163533 SGTC_2869 9037858 32.47 µM -0.676196198811736 0.229922550585351 no 2598 0.249458042821894 3611 27187042 SGTC_901 1112-0062 60.1 µM -0.676803276870107 0.229717104632372 no 2599 0.249265389388932 3647 1908457 SGTC_2597 laccaic acid a 100 µM -0.677549810961288 0.229464605300206 no 2600 0.249028588726043 3606 5491415 A textile dye. SGTC_3092 9117248 49.47 µM -0.681127744517755 0.228256606601341 no 2601 0.247895331477589 3688 17141857 SGTC_1243 0416-0003 5.65 µM -0.681289793712142 0.228201979543104 no 2602 0.247844070041782 3650 2141977 SGTC_2767 sibutramine 71.45 µM -0.681655410753362 0.228078756421288 no 2603 0.247728434257591 3697 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2419 paclitaxel 166.5 µM -0.682572971466657 0.227769677763763 no 2604 0.247438359024598 3605 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3295 9122362 53.5725 µM -0.682854497001478 0.227674893679741 no 2605 0.247349394686235 3645 4730473 SGTC_472 calcifediol 10 µM -0.682919602715147 0.227652977034279 no 2606 0.247328823190442 3647 5283731 A vitamin D metabolite. SGTC_379 3970-0972 5.9 µM -0.683530914776686 0.227447247974235 no 2607 0.247135711129084 3652 2898042 YBL034C STU1 SGTC_741 4582-0002 126 µM -0.683804821328387 0.227355102298754 no 2608 0.247049210854851 3627 2912688 SGTC_1452 4194-0072 190 µM -0.684773680447065 0.227029334497809 no 2609 0.246743373093552 3682 1343545 SGTC_3211 9128781 49.47 µM -0.685072285382416 0.226928985087505 no 2610 0.246649153973699 3638 17194361 SGTC_1632 st005650 90 µM -0.686660910079455 0.22639553139826 no 2611 0.24614821771409 3654 2759605 SGTC_2776 terbinafine 19.92 µM -0.686824197883973 0.22634074018693 no 2612 0.246096759602259 3662 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2301 7769476 200 µM -0.687611670148209 0.226076609107453 no 2613 0.245848678589095 3667 977820 SGTC_854 0422-0053 192 µM -0.688568225040361 0.225755999416041 no 2614 0.245547511346249 3668 3596728 SGTC_2236 dapsone 200 µM -0.688989266251483 0.225614960068492 no 2615 0.245415011153488 3675 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2414 st077232 92.9 µM -0.689116368800444 0.225572393369421 no 2616 0.245375019978417 3629 729801 SGTC_1669 st015249 58.4 µM -0.689702227505327 0.225376247799481 no 2617 0.24519073239116 3725 722793 SGTC_922 1866-0035 480 µM -0.692139489855164 0.224561289373389 no 2618 0.244424867155599 3658 3156169 SGTC_1111 tnp00062 510.699 nM -0.692610059520456 0.224404135651333 no 2619 0.244277147824433 3702 676306 SGTC_3078 9116413 49.47 µM -0.693052543634045 0.224256418476817 no 2620 0.244138288909299 3610 17177322 SGTC_258 haloperidol 50.781 µM -0.693201195001476 0.224206805674605 no 2621 0.244091649177749 3664 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_693 4161-2696 114 µM -0.693324821317208 0.224165549799654 no 2622 0.2440528647779 3676 805759 SGTC_76 0433-0009 400.328 µM -0.694040810479063 0.223926698750278 no 2623 0.243828308005052 3688 2841569 SGTC_1347 1493-0251 600 nM -0.694245158227245 0.223858555715661 no 2624 0.243764238570184 3695 3986378 SGTC_1266 0828-0227 32.9 µM -0.695197115577961 0.223541265643107 no 2625 0.243465889865503 3653 3913820 SGTC_3326 9140064 16.379 µM -0.698286558193555 0.22251330965232 no 2626 0.242499001892353 3652 1868434 SGTC_2081 5214970 32.255 µM -0.699100579606274 0.222242908151287 no 2627 0.242244588169445 3631 2063512 SGTC_2110 5483698 200 µM -0.699460055918505 0.222123557076512 no 2628 0.242132283744175 3691 2848765 YHR062C RPP1 SGTC_1214 0358-0031 63.7 µM -0.700049436885858 0.221927953680838 no 2629 0.241948215628116 3725 4301366 SGTC_2924 9010168 62.78 µM -0.700600937094237 0.221745011244078 no 2630 0.241776046724437 3722 2993929 SGTC_1268 0828-0275 2.46 µM -0.700668678732428 0.221722546079554 no 2631 0.241754903533116 3725 745337 SGTC_3301 9125354 19.7965 µM -0.7008616828035 0.221658547255706 no 2632 0.241694669542025 3660 41905162 SGTC_1482 3346-2049 8.48 µM -0.701576007800555 0.221421773846978 no 2633 0.241471809143865 3693 3826804 SGTC_863 0466-0191 129 µM -0.701834385773518 0.221336166336125 no 2634 0.241391225967472 3685 765160 YPR165W RHO1 SGTC_427 1354-0053 47.3 µM -0.702364584896174 0.221160556516319 no 2635 0.241225912701369 3720 6813657 SGTC_2388 9080168 200 µM -0.704628806849071 0.220411510298942 no 2636 0.240520633306841 3648 15943073 SGTC_2959 9079155 11 µM -0.70515567168429 0.220237422507797 no 2637 0.240356682083904 3666 16189457 SGTC_3028 9087778 49.47 µM -0.706404216649992 0.219825190602254 no 2638 0.239968399689991 3661 17217395 SGTC_1779 st039427 55 µM -0.7085601853968 0.219114398428574 no 2639 0.239298725524663 3724 1124498 SGTC_2409 alverine citrate 63.97 µM -0.708984083971306 0.218974800727349 no 2640 0.2391671768794 3814 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1401 3807-4679 7.6 µM -0.709168662729493 0.218914031492426 no 2641 0.239109908818867 3676 3291456 SGTC_1010 4112-3296 15.2 µM -0.710330289780692 0.218531809405931 no 2642 0.238749670355268 3718 704384 SGTC_3288 9119690 36.221 µM -0.711364866245395 0.218191715829295 no 2643 0.238429082385853 3692 17595618 YKL019W RAM2 SGTC_1074 carmofur 3.8 µM -0.712307284758745 0.217882182723923 no 2644 0.238137257006653 3722 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_615 k087-0205 167 µM -0.71284662306683 0.217705153484139 no 2645 0.237970335858193 3701 9642773 SGTC_2131 toluylene red 5.2905 µM -0.71296882194811 0.217665055175015 no 2646 0.23793252513866 3700 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_750 4073-0104 132 µM -0.713181456957218 0.217595291338626 no 2647 0.237866739568735 3571 22330957 SGTC_1055 3448-0672 86 µM -0.7145667086388 0.217141117377032 no 2648 0.237438411059459 3690 748378 SGTC_2558 carylophyllene oxide 100 µM -0.715921364038783 0.216697504956647 no 2649 0.237019952946126 3789 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2655 perillic acid 100 µM -0.716419776959272 0.216534420414627 no 2650 0.236866093390509 3707 5702197 An apoptosis inducer. SGTC_3276 9139060 49.47 µM -0.718480256420281 0.215860969741176 no 2651 0.236230608636058 3773 4870619 SGTC_215 1287-0124 461.5 µM -0.719110719648595 0.215655150821272 no 2652 0.236036351482676 3717 5560863 SGTC_2154 5570129 200 µM -0.720103986149662 0.215331123299304 no 2653 0.235730486710414 3722 673366 SGTC_2749 bexarotene 57.39 µM -0.720155779463319 0.215314234822484 no 2654 0.235714543564659 3726 82146 An retinoic acid receptor inhibitor. SGTC_1647 st011722 22.4 µM -0.721401315390311 0.214908328913907 no 2655 0.235331318766161 3699 2854783 SGTC_1766 st045414 44.774 µM -0.722114236263856 0.214676196302084 no 2656 0.235112123107253 3753 253960 SGTC_1527 coumarin 137 µM -0.722524191063797 0.214542777827475 no 2657 0.234986128910319 3739 323 A hepatotoxic, DNA x-linker. SGTC_1672 st016598 6.51 µM -0.725617141521938 0.213537741890034 no 2658 0.234036754865319 3738 4665860 YNL267W PIK1 SGTC_1282 0886-0010 32.4 µM -0.725842346747883 0.213464670097733 no 2659 0.233967711710806 3776 2836211 YNL267W PIK1 SGTC_2614 arthonioic acid 13.39 µM -0.728347424609817 0.212652836769624 no 2660 0.233200469184316 3675 6710684 SGTC_3193 9111931 49.47 µM -0.729967038996621 0.212128921126524 no 2661 0.232705166208187 3777 17087244 SGTC_354 2783-3500 4.88 µM -0.730334443110157 0.212010177715011 no 2662 0.232592889797788 3716 6740761 SGTC_414 piperonyl butoxide 100 µM -0.730380329360816 0.211995350209564 no 2663 0.232578869361035 3703 5794 A potent inhibitor of cytochrome P450. SGTC_3030 9087619 49.47 µM -0.730807973950506 0.211857191959923 no 2664 0.232448226152471 3723 25236973 SGTC_773 4358-1457 44.6 µM -0.731169516370941 0.211740430303997 no 2665 0.232337808659534 3720 1186886 SGTC_845 0330-0138 4.51 µM -0.731995062890115 0.211473957773184 no 2666 0.23208579060124 3679 9039800 SGTC_2889 9059656 51.95 µM -0.732256474283126 0.211389619526289 no 2667 0.232006020179585 3807 3949838 SGTC_1445 4239-0156 97.7 µM -0.732310813638052 0.211372090682969 no 2668 0.231989440289307 3797 4008346 SGTC_966 1300-0360 30.2 µM -0.732700709883447 0.211246342535165 no 2669 0.231870495457823 3725 70588 SGTC_3141 9094609 49.47 µM -0.736110293232822 0.21014856303727 no 2670 0.230831789546618 3694 25236309 YDL196W YDL196W SGTC_1330 1469-0054 61.8 µM -0.736270902708195 0.210096934572518 no 2671 0.230782925153818 3746 7102664 SGTC_823 0417-1665 178 µM -0.737429085599612 0.20972485338916 no 2672 0.230430726607969 3764 3429856 SGTC_3280 9140961 49.47 µM -0.738109893791351 0.209506315917391 no 2673 0.230223836006604 3753 4901226 SGTC_1925 st057770 10.1 µM -0.742693643738109 0.208038436338213 no 2674 0.228833589449734 3727 5989122 SGTC_3088 9117578 49.47 µM -0.743120141601996 0.207902165975695 no 2675 0.228704473156492 3801 678341 SGTC_2537 larixol 68.93 µM -0.743526240926143 0.207772462150837 no 2676 0.228581570264098 3753 6708759 SGTC_1367 1812-0510 76.9 µM -0.746858752313649 0.206709899958471 no 2677 0.227574413251548 3773 1142582 YDR527W RBA50 SGTC_115 0527-0192 112.043 µM -0.748291862694144 0.206253947753542 no 2678 0.22714206583878 3796 4233931 SGTC_549 1661-1316 519 µM -0.748572952598703 0.206164587384252 no 2679 0.22705731967381 3774 2857282 SGTC_378 3970-0959 8.33 µM -0.748637677262235 0.206144014230416 no 2680 0.227037808275273 3771 6615653 SGTC_3318 9139014 38.6185 µM -0.74907724624846 0.206004326585409 no 2681 0.226905324208914 3742 16643984 SGTC_627 1391-0720 175 µM -0.749388430644713 0.205905471354869 no 2682 0.226811561033531 3753 997839 SGTC_2321 7390090 138.78 µM -0.749574422491837 0.205846399996188 no 2683 0.226755530145993 3756 649046 SGTC_2826 7992541 19.48 µM -0.751842576301098 0.205126839374834 no 2684 0.22607286721357 3809 2985066 SGTC_2432 5630864 12.22 µM -0.752259717135092 0.204994666422231 no 2685 0.225947443853389 3753 5714970 SGTC_105 0111-0055 734.78 µM -0.753559910362939 0.20458301929195 no 2686 0.225556762212101 3790 5179370 SGTC_2338 7999974 200 µM -0.753694606395987 0.204540402045939 no 2687 0.22551631065744 3821 315925 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.753766887707845 0.204517534727778 no 2688 0.225494605019008 3781 521171 SGTC_2366 9070441 60.58 µM -0.754036672700217 0.204432197483552 no 2689 0.225413600670736 3766 6837235 SGTC_1679 SEC14.276 6.7 µM -0.755033540523107 0.204117056379895 no 2690 0.225114428861334 3808 1005053 YMR079W SEC14 SGTC_393 acivicin 6.25 µM -0.755059275651712 0.20410892453415 no 2691 0.225106708425189 3652 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1641 st009299 47.1 µM -0.7573417611657 0.203388467256715 no 2692 0.224422568799629 3700 4046054 SGTC_2228 7354201 200 µM -0.757943728247358 0.203198711942758 no 2693 0.224242335349049 3781 753451 SGTC_1160 4092-0570 10.5 µM -0.75800577021495 0.203179160747402 no 2694 0.224223764192402 3748 4994975 SGTC_1896 st058441 89 µM -0.758972350909477 0.202874708621727 no 2695 0.223934548309352 3795 688759 SGTC_1873 rapamycin 2 nM -0.75897841388442 0.202872799775486 no 2696 0.223932734842782 3739 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2867 9039098 71.43 µM -0.760007707212479 0.20254889612876 no 2697 0.22362498897121 3742 6463460 SGTC_1129 3453-1384 223 µM -0.760038437581326 0.202539230483398 no 2698 0.223615804672994 3903 1084452 SGTC_1545 lovastatin 49.4 µM -0.762240408599457 0.201847360889646 no 2699 0.222958266429939 3848 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2853 9015042 58.44 µM -0.763331615898838 0.201505023471816 no 2700 0.22263282575975 3722 6457456 SGTC_1178 0988-0033 191 µM -0.763962962632302 0.201307114112043 no 2701 0.222444657214469 3808 5392207 SGTC_18 0111-0177 500 nM -0.766181994161891 0.200612435508446 no 2702 0.221784010275909 3850 721752 SGTC_1406 3909-7906 11.9 µM -0.76641450736538 0.200539729521818 no 2703 0.2217148517066 3791 X1406 SGTC_1089 terbinafine 2.25 µM -0.766692310463075 0.200452882309079 no 2704 0.221632238299395 3779 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1357 1503-1303 39.5 µM -0.768751119738252 0.199809958679991 no 2705 0.221020535739416 3773 292895 SGTC_2214 7179297 48.276 µM -0.769729048343214 0.199505006766003 no 2706 0.22073031756567 3797 769744 SGTC_1979 st071809 45.3 µM -0.770204832967989 0.199356742045637 no 2707 0.220589198749842 3898 4976333 SGTC_2346 9031566 143.75 µM -0.770248025828315 0.199343285507117 no 2708 0.220576390207718 3767 4771086 SGTC_2998 9066762 71.4286 µM -0.770383407229651 0.199301111593123 no 2709 0.220536246556348 3797 4945196 SGTC_3305 9127027 53.8275 µM -0.771167860303933 0.199056845134971 no 2710 0.220303720876036 3724 41905295 SGTC_1981 st071826 47 µM -0.773848087135488 0.19822362626427 no 2711 0.219510315907866 3806 11838600 SGTC_957 1187-1561 14.1 µM -0.775102157065282 0.197834489774726 no 2712 0.219139648543575 3762 1538454 SGTC_2281 7943571 200 µM -0.7763090623587 0.197460424579101 no 2713 0.218783261764297 3898 1244024 SGTC_654 1124-0271 80.9 µM -0.776776085286764 0.197315791506184 no 2714 0.218645444224949 3797 5403748 SGTC_1791 st048313 56.1 µM -0.777246552269657 0.197170156646397 no 2715 0.2185066608935 3732 1204976 SGTC_1844 rapamycin 4 nM -0.777320113263282 0.197147391439598 no 2716 0.218484965679476 3739 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2600 tangeritin 87.95 µM -0.777831521717084 0.196989167844825 no 2717 0.218334171179901 3751 68077 A bioactive flavone. SGTC_3185 9108267 49.47 µM -0.778098274292011 0.196906668333505 no 2718 0.218255539999542 3756 4910486 SGTC_2706 st078239 82.5 µM -0.778220453842153 0.196868888417948 no 2719 0.218219530342491 3789 15434492 SGTC_2882 9058044 58.44 µM -0.780970618773236 0.196019654115427 no 2720 0.217409887749659 3769 18076804 SGTC_1363 1636-0063 10.4 µM -0.781141474001705 0.195966968473195 no 2721 0.217359645626917 3803 6072185 SGTC_3098 9119039 49.47 µM -0.781405518679526 0.195885563437039 no 2722 0.217282013165991 3796 17161528 SGTC_2227 7312221 64.1025 µM -0.78198672229903 0.195706450530375 no 2723 0.217111188410685 3828 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1208 2323-2347 50.3 µM -0.783744329896427 0.195165403564822 no 2724 0.216595072669656 3793 5412760 SGTC_719 2810-4230 27.3 µM -0.784990159558943 0.194782449081521 no 2725 0.216229669091196 3789 721079 SGTC_2473 5854593 8.94 µM -0.78913028628416 0.193513106113375 no 2726 0.215017931088253 3731 2872951 SGTC_1744 st037937 38.9 µM -0.789407599205455 0.193428263991053 no 2727 0.214936907908628 3862 1016152 SGTC_678 1218-2179 85.9 µM -0.789433306113055 0.1934204002759 no 2728 0.214929397958123 3799 6820081 YOR116C RPO31 SGTC_757 1066-0008 322 µM -0.791876839070344 0.192673816844325 no 2729 0.214216246475471 3868 6842497 SGTC_1358 1509-0022 2.48 µM -0.792118207038384 0.19260016630985 no 2730 0.214145877390342 3857 3258434 SGTC_1254 0550-0035 264 µM -0.793098037298983 0.192301359631015 no 2731 0.213860353133701 3905 15121435 SGTC_3279 9140807 49.47 µM -0.79411310203461 0.191992107112899 no 2732 0.21356479539258 3858 45595718 SGTC_582 0987-0078 156 µM -0.797509143857286 0.19095967386154 no 2733 0.212577697238365 3877 1625765 SGTC_1170 0310-0127 64.8 µM -0.79842127512758 0.190682957372423 no 2734 0.212313030582209 3848 774975 SGTC_3233 9132340 49.47 µM -0.800070679954316 0.190183196891626 no 2735 0.211834923776568 3838 17682950 SGTC_2273 7815444 169.05 µM -0.800853941774449 0.189946155011408 no 2736 0.211608103374751 3755 2824616 SGTC_97 0535-0701 19.132 µM -0.801220425177901 0.189835306967497 no 2737 0.211502024341124 3753 2832013 YGL099W LSG1 SGTC_2304 7443016 91.4 µM -0.808273585691786 0.18770973544161 no 2738 0.209466552446607 3777 939854 SGTC_834 0312-0008 75.7 µM -0.808547425854491 0.187627507336195 no 2739 0.209387758018807 3829 6385573 YIL048W NEO1 SGTC_1027 k015-0025 8.67 µM -0.810048453998728 0.187177177429513 no 2740 0.20895616397268 3832 3598955 SGTC_2623 humulene 100 µM -0.81126403584613 0.186812975774582 no 2741 0.208607029275389 3817 6187145 An anti-inflammatory. SGTC_2271 7849410 118.62 µM -0.811774281833361 0.186660231257772 no 2742 0.208460580936916 3778 972430 SGTC_3022 9087993 49.47 µM -0.812573747382771 0.186421063050456 no 2743 0.208231244155613 3870 17173644 SGTC_836 0330-0104 1.35 µM -0.812998436461643 0.18629409025275 no 2744 0.208109477303183 3844 46494820 SGTC_1155 4088-0394 48.2 µM -0.813988432060193 0.185998311210611 no 2745 0.207825788984408 3837 2326248 SGTC_592 k241-0073 46.5 µM -0.815206840756645 0.185634689550665 no 2746 0.207476961414695 3842 4230158 SGTC_1619 st003326 88.7 µM -0.816620079477362 0.185213475786941 no 2747 0.207072788268352 3809 2849032 SGTC_2922 7999257 32.47 µM -0.816720362884731 0.185183609032593 no 2748 0.207044125855925 3823 2988377 SGTC_1087 pterostilbene 9.05 µM -0.817956385641111 0.184815738094687 no 2749 0.206691045917485 3919 5281727 Similar to reservatol, lowers cholesterol. SGTC_438 sphingosine 6.67 µM -0.819040853461004 0.184493348028374 no 2750 0.206381552720078 3826 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1092 toremifene 6.32 µM -0.819492075472409 0.18435931207815 no 2751 0.206252860691169 3850 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_681 1642-0006 26.6 µM -0.819599649460559 0.184327366063182 no 2752 0.206222186775867 3869 4446530 SGTC_3356 9151811 4.48 µM -0.819884823983255 0.184242695070309 no 2753 0.206140884488461 3849 1859254 YPR165W RHO1 SGTC_577 r071-0003 38.6 µM -0.820390876550668 0.184092502908943 no 2754 0.205996657413265 3896 4568517 YMR134W ERG29 SGTC_990 3985-0011 41.3 µM -0.822327857150898 0.183518327782803 no 2755 0.205445163137547 3880 5399565 YGL099W LSG1 SGTC_2926 9010726 65.15 µM -0.823375510446258 0.183208239730034 no 2756 0.205147242542814 3897 2994293 SGTC_1300 1094-0077 113 µM -0.823620527327346 0.183135765961005 no 2757 0.205077604286013 3819 5532636 SGTC_1752 st044819 83.042 µM -0.82381751853805 0.18307751072011 no 2758 0.205021625988907 3880 441209 YML126C ERG13 SGTC_2161 5662504 8.5105 µM -0.824102447381774 0.182993270572203 no 2759 0.204940674836432 3843 2859334 SGTC_684 1140-0066 328 µM -0.825575390630305 0.182558175856606 no 2760 0.204522499962112 3915 6813534 SGTC_763 3453-1109 128 µM -0.826791624867298 0.182199398194746 no 2761 0.204177588923021 3888 1560353 SGTC_1919 st067113 52.3 µM -0.827052508406434 0.182122497446274 no 2762 0.204103650286626 3922 1268243 SGTC_2033 5192550 145 µM -0.827809255230346 0.181899545682731 no 2763 0.20388926618404 3864 182073 SGTC_2355 9061122 103.12 µM -0.82906514461472 0.181529914088582 no 2764 0.203533772805801 3899 5302957 SGTC_788 1182-0090 188 µM -0.829688665598311 0.181346575040068 no 2765 0.203357415716607 3966 5715185 SGTC_2072 5231554 129 µM -0.830147677504678 0.181211682079294 no 2766 0.203227646770971 3922 789545 SGTC_2731 amoxapine 43.43 µM -0.830780953539825 0.181025680121786 no 2767 0.203048692129611 3943 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1915 st067105 30.6 µM -0.831988929211418 0.18067121276812 no 2768 0.202707596721774 3848 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2071 5230951 39.92 µM -0.832172286843984 0.180617446529634 no 2769 0.202655852078287 3908 1799272 SGTC_2607 solasodine 47.35 µM -0.835973828163411 0.179504976142712 no 2770 0.201584813356306 3904 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.836892827326206 0.179236691092454 no 2771 0.201326406239925 3904 229346 A bile salt which induces apoptosis. SGTC_926 2268-1401 59.4 µM -0.837758041094417 0.178984338309394 no 2772 0.201083304236276 3856 2931578 SGTC_560 2332-1943 155 µM -0.837824561572714 0.178964945857569 no 2773 0.201064621046465 3855 21177716 SGTC_2371 9071574 200 µM -0.839273295752125 0.178542930121249 no 2774 0.200657982474075 3882 45596039 SGTC_2058 5236698 133 µM -0.841688027762223 0.177840913879468 no 2775 0.199981300696102 3900 766665 SGTC_2880 9042983 58.44 µM -0.844302253619181 0.177082865978859 no 2776 0.199250263549905 3923 6464714 SGTC_2846 9008642 19.48 µM -0.846615909705662 0.176413679787325 no 2777 0.198604621564785 3973 2992898 SGTC_2733 amorolfine 100 µM -0.849635312269096 0.175542777933233 no 2778 0.197763936512175 3952 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_255 tunicamycin 200.472 nM -0.850507363635841 0.175291755652198 no 2779 0.1975215341141 3852 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1489 4065-0444 182 µM -0.851633952409957 0.174967801253459 no 2780 0.19720864452377 3852 2877968 SGTC_1057 3448-5381 134 µM -0.852871511259368 0.174612375191036 no 2781 0.19686528085707 3944 5497911 SGTC_2539 epi(13)torulosol 80 µM -0.85290642648108 0.174602354217352 no 2782 0.196855598798349 3953 6708597 SGTC_1216 1165-0504 9.65 µM -0.854192256911947 0.174233564037804 no 2783 0.196499236378233 3902 6304004 SGTC_3074 9116018 49.47 µM -0.855501049410808 0.17385869682527 no 2784 0.196136911855494 3959 17027303 SGTC_1341 1486-1360 280 µM -0.855530073012564 0.173850389639423 no 2785 0.196128881591674 3885 3976547 SGTC_3258 9138477 49.47 µM -0.86132605483669 0.172196513841026 no 2786 0.194529244770717 3952 4970355 SGTC_2784 7567673 72.73 µM -0.862080153751056 0.171982073243029 no 2787 0.194321705851145 3897 3471247 SGTC_2247 cerulenin 830 nM -0.863041392931695 0.171708976138165 no 2788 0.194057354477672 3937 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1244 0416-0015 52.5 µM -0.864309708227236 0.171349059955104 no 2789 0.193708889238427 3902 96201 SGTC_3175 9106517 49.47 µM -0.864573037483982 0.17127439419415 no 2790 0.19363658829351 3957 41468073 SGTC_2233 sulbentine 40.3845 µM -0.866103165362333 0.170840945391492 no 2791 0.193216794753539 3893 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_101 0490-5701 117.494 µM -0.86735545527919 0.170486724267775 no 2792 0.192873640285581 3746 4661669 SGTC_29 0299-0004 12.984 µM -0.867383634371847 0.170478758980057 no 2793 0.19286592289105 3813 16871 A napthoquinone isolated from Swertia calycina. SGTC_2330 7979373 200 µM -0.86764830079829 0.170403958257678 no 2794 0.192793448030261 3881 1863007 SGTC_480 am 92016 50 µM -0.868352369784751 0.170205074782687 no 2795 0.192600730505569 3883 2129 K+ channel blocker. SGTC_1112 tnp00069 1.16933 µM -0.869231898582286 0.169956836935538 no 2796 0.192360151659188 3943 145826 SGTC_1674 st016616 23.6 µM -0.87056169104939 0.16958195782432 no 2797 0.191996760654912 3897 625830 SGTC_5 0352-0601 109.883 µM -0.871369968564082 0.169354357354765 no 2798 0.191776088932065 3856 762456 SGTC_139 0099-0334 718.624 µM -0.871758586800048 0.169244997325136 no 2799 0.19167004570819 3972 97690 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.87353678001793 0.168745179157487 no 2800 0.191185283960996 3976 6710655 SGTC_1550 gossypolone 36.6 µM -0.87398013657333 0.168620707483345 no 2801 0.191064535583577 3940 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1899 st063254 59.6 µM -0.876016717764196 0.168049698878093 no 2802 0.190510472750926 3868 3093813 SGTC_1197 1601-0112 267 µM -0.876724793195873 0.167851463351021 no 2803 0.190318068382795 3914 7350313 SGTC_289 k017-0060 526 µM -0.880749369668364 0.166727588494678 no 2804 0.189226744462469 3916 5512909 SGTC_2830 7992007 71.43 µM -0.880898640419578 0.166685997796477 no 2805 0.1891863417153 3837 1952075 SGTC_60 0986-0278 202 µM -0.883457596754575 0.165974047589926 no 2806 0.188494541600436 3890 3110598 SGTC_963 1269-2853 151 µM -0.88348441471324 0.165966596745277 no 2807 0.188487299779246 3930 3668223 SGTC_3192 9110362 49.47 µM -0.884480042557146 0.165690134026571 no 2808 0.188218565601405 3966 16649480 SGTC_2656 pseudo-anisatin 100 µM -0.88530178613244 0.165462179367316 no 2809 0.187996943454733 3973 6708809 A neurotoxin. SGTC_2865 9030313 51.95 µM -0.888093618577783 0.164689231184118 no 2810 0.187245197501024 3897 42562754 SGTC_879 0831-1030 162 µM -0.889636768625993 0.164262999396042 no 2811 0.186830478215111 3989 1549252 SGTC_2824 7998404 51.95 µM -0.889655093267228 0.164257942268298 no 2812 0.186825556912788 3924 837851 SGTC_2133 5320837 200 µM -0.890491092082414 0.164027335555245 no 2813 0.186601124725284 3989 2841355 SGTC_3189 9110682 49.47 µM -0.891227956640356 0.163824248844065 no 2814 0.186403444595837 4048 17122418 SGTC_2854 9024559 71.43 µM -0.89138054779832 0.163782213709531 no 2815 0.186362524879612 4016 3163529 SGTC_1321 1326-2144 215 µM -0.894402031051527 0.162951310846623 no 2816 0.185553413085488 3975 3513030 SGTC_343 4130-2827 29.8 µM -0.896643495905039 0.162336685523466 no 2817 0.184954590242979 4001 1118244 SGTC_2440 5628896 157.78 µM -0.897282204856642 0.1621618236924 no 2818 0.184784174813001 3966 5522048 SGTC_3220 9131269 49.47 µM -0.898034123436454 0.161956125264372 no 2819 0.184583678788434 3992 17722206 SGTC_1323 1348-1351 11.2 µM -0.90090671533426 0.161171851123191 no 2820 0.183818960217545 3925 6989654 SGTC_2783 7738165 71.43 µM -0.906849262331596 0.159557297272218 no 2821 0.182243257540291 3991 17201110 SGTC_2170 morpholine 200 µM -0.907290356833428 0.159437878090473 no 2822 0.182126636140587 4012 121171 Reacts with secondary amines. SGTC_2287 7945887 168.79 µM -0.91037280992355 0.158604987541591 no 2823 0.181312966048786 3996 1245853 SGTC_3316 9136639 10.545 µM -0.910876944182446 0.158469040507966 no 2824 0.181180107469226 4006 4903665 SGTC_1256 0570-0116 285 µM -0.911411358200458 0.158325011583134 no 2825 0.181039335620481 4002 410638 SGTC_3352 9151559 45.5865 µM -0.91221421003834 0.158108797966942 no 2826 0.180827982483009 3985 17159339 SGTC_1234 0326-0494 15.5 µM -0.915144953416995 0.157321174082846 no 2827 0.180057769096859 4069 1547813 SGTC_338 4055-0136 114 µM -0.915203401788161 0.157305492628548 no 2828 0.180042429563133 3932 2900563 SGTC_2720 fluspirilene 36.88 µM -0.917411425733491 0.156713841698263 no 2829 0.179463543863513 3982 3396 An atypical antipsychotic. SGTC_838 0109-0203 71.4 µM -0.919313738533727 0.156205283589141 no 2830 0.178965746937275 4004 759422 SGTC_2517 totarol 10 µM -0.919643590848111 0.156117212680551 no 2831 0.178879519710746 4017 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1733 st037357 54.9 µM -0.920206152930393 0.155967083527091 no 2832 0.178732519785787 3912 1272339 YGL099W LSG1 SGTC_1555 citronellol 128 µM -0.922664547222177 0.155312136560647 no 2833 0.178091023390089 3928 8842 A terpine precursor. SGTC_1147 3809-1045 12.3 µM -0.923568389135811 0.155071798784441 no 2834 0.177855539165188 3972 325925 SGTC_2418 pentamidine 31.67 µM -0.924731006124031 0.154763012218283 no 2835 0.177552923401487 3972 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2332 7982454 138.89 µM -0.928979481348084 0.15363809039892 no 2836 0.176449860035781 3941 2981748 SGTC_675 1309-0189 238 µM -0.930962315099823 0.153114928426746 no 2837 0.1759365290687 4039 4246530 SGTC_1114 scopoletin 1.73284 µM -0.930965036825911 0.153114211123712 no 2838 0.175935825098284 4043 5280460 A coumarin with genotoxic properties. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.93099615618711 0.153106009864445 no 2839 0.175927776248451 3977 688803 SGTC_233 rapamycin 362 pM -0.932593071316194 0.152685546451162 no 2840 0.175515056059596 4005 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_679 0422-0091 41.4 µM -0.934138359931546 0.152279406043223 no 2841 0.175116263391755 3988 627384 YHR062C RPP1 SGTC_1911 st060208 74.3 µM -0.934653350201636 0.152144213229347 no 2842 0.174983487634994 4063 688783 SGTC_1984 st072354 53.1 µM -0.935976025210677 0.151797356149696 no 2843 0.174642765884884 3893 5762938 SGTC_2496 diffractaic acid 79.83 µM -0.939546627299747 0.150863630424385 no 2844 0.173725082198373 4032 94870 An apoptosis inducer which activates caspases. SGTC_688 0527-0193 473 µM -0.941779810169022 0.15028159225243 no 2845 0.17315269199084 4044 4007154 SGTC_547 1120-0019 610 nM -0.94404304816578 0.149693249533976 no 2846 0.172573825265513 3958 3676939 SGTC_658 3253-0951 102 µM -0.944234726818572 0.149643492163354 no 2847 0.172524856501111 4035 1184878 SGTC_2817 7995342 71.43 µM -0.944287389629931 0.14962982349171 no 2848 0.172511404114501 4030 18879975 SGTC_2296 7971656 126.45 µM -0.946034510079354 0.149176829346687 no 2849 0.172065492349175 4072 666570 SGTC_513 4245-1575 41.7 µM -0.94616769675586 0.149142334257695 no 2850 0.172031529761895 3937 719745 SGTC_626 0214-0009 33 µM -0.946415183652309 0.149078249782976 no 2851 0.171968431996287 4097 3437874 SGTC_2765 myclobutanil 7.74 µM -0.946767810503756 0.148986972053843 no 2852 0.171878553910032 4069 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_843 0310-0051 143 µM -0.947534145323368 0.148788734465937 no 2853 0.171683332733904 4051 2065037 SGTC_1961 st076550 68.7 µM -0.947742447808102 0.148734880693866 no 2854 0.171630292880984 4058 1579337 SGTC_1765 st044815 90.4 µM -0.947760743234957 0.14873015128277 no 2855 0.171625634834954 4071 645695 SGTC_521 r062-0005 13.8 µM -0.948833384200909 0.148453046755068 no 2856 0.171352679852981 3933 2832033 SGTC_3347 9188721 44.724 µM -0.949127330185555 0.148377169482612 no 2857 0.171277927878078 4062 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1788 fluconazole 20 µM -0.949201527996697 0.148358020651292 no 2858 0.17125906228935 4080 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1242 0402-0103 60.1 µM -0.949987493905137 0.148155281545052 no 2859 0.171059303614017 3964 432868 SGTC_701 4424-0219 185 µM -0.951349058441769 0.147804506298498 no 2860 0.170713605432778 4081 2911779 SGTC_2241 6772625 37.8075 µM -0.951862451402854 0.14767238710163 no 2861 0.170583372287773 3910 2285411 SGTC_2095 5432005 200 µM -0.952210422925279 0.147582883299503 no 2862 0.170495138019053 4039 783734 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.953352426011803 0.147289397340595 no 2863 0.170205768543608 3964 97141 SGTC_783 0848-0141 92.7 µM -0.954564811380162 0.146978252036921 no 2864 0.169898909649081 3975 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2681 menadione 3.18 µM -0.955007346478115 0.146864790188398 no 2865 0.169786990915318 4060 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_401 neomycin 50 µM -0.955262440921418 0.146799413067494 no 2866 0.169722498090372 4009 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_630 4356-0227 183 µM -0.95600621280172 0.146608906252116 no 2867 0.169534547829729 4009 779312 SGTC_2200 6600604 21.907 µM -0.956991560509685 0.146356778758783 no 2868 0.169285757377422 4010 2904777 SGTC_824 1304-0008 100 µM -0.957531127079146 0.146218839688069 no 2869 0.169149621566969 4059 768245 SGTC_2216 7189485 200 µM -0.958098567612442 0.146073868920045 no 2870 0.169006528851296 4046 731273 SGTC_1354 1498-1681 81 µM -0.962382056938883 0.144982631219386 no 2871 0.167928861743746 4049 5754243 SGTC_145 3737-0113 38.366 µM -0.963138758551192 0.144790429997567 no 2872 0.167738946731504 4003 6849351 SGTC_2359 9039622 200 µM -0.963502421633124 0.144698121123867 no 2873 0.167647724737834 4001 6463596 SGTC_664 1222-0054 14.9 µM -0.96420385997354 0.144520186483956 no 2874 0.167471864772693 4013 6813991 SGTC_64 000l-0018 272.079 µM -0.966691597814172 0.143890308275743 no 2875 0.166849114327231 3985 6811119 SGTC_1082 camptothecin 424.86 nM -0.968273737703952 0.143490686066696 no 2876 0.166453838556823 3961 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_278 4092-0821 23.9 µM -0.970487371237127 0.142932817670946 no 2877 0.16590180838612 4050 877900 SGTC_191 3914-0123 66.505 µM -0.970919057133865 0.142824197456745 no 2878 0.165794293712802 4027 3144412 SGTC_1904 st060225 78 µM -0.971408283963664 0.142701166333531 no 2879 0.165672502491829 3992 66595 SGTC_2416 tofa 880 nM -0.97308584915013 0.142279835220331 no 2880 0.165255318226055 4089 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1264 0783-0040 158 µM -0.973154134489753 0.142262702771912 no 2881 0.165238351140826 3945 2855798 SGTC_162 k030-0015 37.8 µM -0.973627495449586 0.14214397726507 no 2882 0.165120764567912 4142 1809920 YMR134W ERG29 SGTC_1376 2910-0861 41.3 µM -0.977049715953585 0.141287631924454 no 2883 0.164272270040711 4001 1112859 SGTC_555 4296-0685 37 µM -0.980137618433495 0.140517950619481 no 2884 0.163509096082632 4017 2908540 YHR072W ERG7 SGTC_718 1130-0073 349 µM -0.981161726147145 0.140263314329599 no 2885 0.163256497508681 4117 6740020 SGTC_1297 1068-0111 14.1 µM -0.982140024996681 0.140020360906102 no 2886 0.163015434718417 4036 767057 SGTC_2068 5226020 147 µM -0.982781418702404 0.139861230712933 no 2887 0.162857514429519 4096 1810509 SGTC_1483 3453-0561 55.9 µM -0.984255092478712 0.13949607710776 no 2888 0.162495051895725 4077 4546991 SGTC_2489 cantharidin 73.42 µM -0.984360261738415 0.139470042600927 no 2889 0.162469204710284 4023 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1016 4226-1401 38 µM -0.984924083083115 0.139330525751222 no 2890 0.162330681374736 4037 2901613 SGTC_3227 9130768 49.47 µM -0.987884523642235 0.13859952712045 no 2891 0.161604602896395 4121 17720899 SGTC_789 1309-1135 70.6 µM -0.987976958637734 0.138576745007199 no 2892 0.161581966398874 4057 3092424 SGTC_2715 st079500 56.4 µM -0.988784455541846 0.138377832716678 no 2893 0.161384305589786 4031 28246688 SGTC_2399 5884133 200 µM -0.989744524756762 0.138141590333665 no 2894 0.161149503090792 4084 722445 SGTC_1002 4049-0206 172 µM -0.990874863598314 0.137863802719925 no 2895 0.160873343880824 4067 4662749 SGTC_640 3381-0960 37.1 µM -0.99096350332009 0.137842035097244 no 2896 0.16085170090116 4128 1745025 SGTC_1165 k072-0275 30.3 µM -0.992664524159308 0.137424762627228 no 2897 0.16043673440311 4051 6153523 YGL055W OLE1 SGTC_2801 7907800 81.82 µM -0.994578949871691 0.13695617296577 no 2898 0.159970544832978 4105 6620925 SGTC_2735 sertaconazole 140 nM -0.995304414277648 0.136778888296232 no 2899 0.159794115749742 4210 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_562 3772-2733 112 µM -0.996112855344262 0.136581511180563 no 2900 0.159597657211457 4098 2876874 YIL048W NEO1 SGTC_583 1488-1091 88.9 µM -0.996303216388373 0.13653506376522 no 2901 0.159551420747839 4198 4303273 SGTC_2822 7994718 71.43 µM -0.997827579305104 0.136163514270603 no 2902 0.159181487120243 4054 1018011 SGTC_1962 st076595 64.5 µM -0.999955506432959 0.135646009669853 no 2903 0.158666020311622 4076 279619 SGTC_2480 5767542 37.17 µM -1.00230948929206 0.135075100616159 no 2904 0.158097070438177 4042 2867358 SGTC_2070 5230947 200 µM -1.00251676739474 0.135024908722841 no 2905 0.158047036236273 4161 2835538 SGTC_2686 alizarin 95.37 µM -1.00258173304255 0.135009180080807 no 2906 0.158031356524981 4095 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_880 0833-0487 87.2 µM -1.00271650421011 0.134976555037037 no 2907 0.157998832237271 4088 76075 SGTC_2838 9002687 71.43 µM -1.00344648503987 0.134799937199968 no 2908 0.157822742541957 4071 6457060 SGTC_976 1348-1067 47.6 µM -1.00351470760075 0.134783438952945 no 2909 0.157806292136446 4104 5310671 YGL099W LSG1 SGTC_1025 k007-0731 70 µM -1.00378558023085 0.134717947555098 no 2910 0.157740988131106 4063 6256118 SGTC_1046 2001-0062 216 µM -1.00604661625807 0.134172127730531 no 2911 0.157196573202252 4004 739778 SGTC_999 SEC7.066 22.7 µM -1.00649521887214 0.134064014771035 no 2912 0.15708870519373 4064 740511 YDR170C SEC7 SGTC_140 0062-0056 502.533 µM -1.01064472226183 0.133066824147771 no 2913 0.156093251380071 4021 3758964 SGTC_237 nikkomycin 200 µM -1.01338840876016 0.132410284065252 no 2914 0.155437336881843 4117 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2152 5568786 200 µM -1.01348766317616 0.132386575267538 no 2915 0.155413642936311 4084 5399883 SGTC_1624 st003710 6.25 µM -1.01370565618649 0.132334513776665 no 2916 0.155361612161221 4146 24207033 SGTC_220 paclitaxel 373.376 µM -1.01408530324968 0.132243879459011 no 2917 0.155271025091448 4065 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1905 st060207 84.5 µM -1.01465175441938 0.132108728389285 no 2918 0.155135929773074 4066 1948547 SGTC_2433 5607874 27.82 µM -1.01470511880453 0.132096000951261 no 2919 0.155123206677632 4070 2252428 SGTC_2618 avocadyne 43.43 µM -1.01560371424338 0.13188181238005 no 2920 0.154909067718953 4003 3015189 SGTC_1078 idebenone 36.1 µM -1.01568065811663 0.13186348323451 no 2921 0.154890740759338 4150 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1070 indatraline 8.81 µM -1.01577779397722 0.131840346574651 no 2922 0.154867606394679 4124 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.01689424462194 0.131574621769792 no 2923 0.154601870780887 4147 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_806 3966-4455 5.86 µM -1.01712716782865 0.131519230691062 no 2924 0.15454646882528 4097 714982 SGTC_2810 7959871 45.46 µM -1.01748387112626 0.13143443487959 no 2925 0.15446165059121 4077 2974535 SGTC_419 nsc-638432 893 µM -1.01828275033012 0.131244661583598 no 2926 0.154271801784578 4073 368090 SGTC_2030 5175110 200 µM -1.0184517416448 0.131204542054793 no 2927 0.154231661803812 4133 2831986 SGTC_647 0140-0236 81 µM -1.02413085369788 0.129861211057579 no 2928 0.152886736521795 4126 990837 SGTC_600 1495-0418 41.6 µM -1.02695620102856 0.12919646579 no 2929 0.152220544263045 4102 5377768 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.02897606985715 0.128722681163379 no 2930 0.151745460020721 4063 4330530 SGTC_2031 5180455 200 µM -1.02919970284467 0.128670299561975 no 2931 0.151692920966259 4069 29949 SGTC_1628 st004252 77.7 µM -1.03018720994017 0.128439172434042 no 2932 0.151461066275096 4151 692968 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.03296634233138 0.127790260847823 no 2933 0.150809824975528 4174 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_187 1488-2104 32.728 µM -1.03325986133534 0.12772185910091 no 2934 0.150741152909188 4125 2852859 SGTC_1414 3917-0015 5.4 µM -1.03465564515354 0.127396933540837 no 2935 0.150414878566986 4100 6618702 SGTC_1444 4112-3581 28 µM -1.03491318253182 0.127337044101377 no 2936 0.150354728837605 4158 2877249 SGTC_3171 9103192 49.47 µM -1.03808300284203 0.126601516818281 no 2937 0.149615706955727 4183 13018434 SGTC_113 0099-0221 2.5 µM -1.03988624738272 0.126184413727861 no 2938 0.149196376286301 4060 89219 SGTC_3063 1327-0034 4 µM -1.0416187813373 0.125784569644011 no 2939 0.148794228797619 4028 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_460 trequinsin 123 µM -1.04173882586387 0.125756897858144 no 2940 0.148766391498105 4188 5537 A vasodilator. SGTC_1731 st035964 63 µM -1.04523439511938 0.124952986453838 no 2941 0.147957325189455 4073 6739575 SGTC_2059 5238311 157 µM -1.04631605794004 0.124704954438878 no 2942 0.147707566965937 4126 703021 SGTC_103 0844-0104 51.839 µM -1.0469209527913 0.124566398403223 no 2943 0.147568018640007 4049 5375804 SGTC_3317 9138495 8.753 µM -1.0469468553316 0.124560467621657 no 2944 0.147562044935758 4050 17020139 SGTC_3296 9122258 64.045 µM -1.04700118422773 0.124548028833712 no 2945 0.147549516005258 4131 4730474 SGTC_1819 st053448 58.6 µM -1.0479237743242 0.124336931227476 no 2946 0.147336863865457 4045 2857616 SGTC_1486 3970-0793 4.53 µM -1.04817659899132 0.124279126186128 no 2947 0.147278624989511 4155 2844330 SGTC_2319 6033012 152.6 µM -1.06039581656929 0.121507743828286 no 2948 0.144482282302136 4112 847246 SGTC_2326 6164455 177.58 µM -1.06080248910698 0.121416261364564 no 2949 0.144389835397846 4122 2888790 SGTC_2401 5128683 200 µM -1.06081169957727 0.12141418999677 no 2950 0.144387742087871 4153 708373 SGTC_2467 5474540 200 µM -1.06927456913722 0.119521440725534 no 2951 0.142472983145251 4117 5413519 SGTC_557 1315-0110 16.2 µM -1.0715495847041 0.119016194897547 no 2952 0.141961194025365 4175 6833801 SGTC_3285 9112818 20.8695 µM -1.07194230383368 0.118929130901423 no 2953 0.141872973781711 4132 17017947 YPR165W RHO1 SGTC_424 splitomicin 100 mM -1.07429595107469 0.118408280834155 no 2954 0.141345029583779 4225 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3167 9103034 49.47 µM -1.07795406954667 0.117601962074241 no 2955 0.140527126989572 4241 5127859 SGTC_1958 st076513 41.9 µM -1.07890384627959 0.117393250322403 no 2956 0.14031529702408 4126 732122 YGL099W LSG1 SGTC_3351 9150312 21.596 µM -1.08339170683429 0.116410599109067 no 2957 0.139317297572131 4101 4904905 SGTC_706 4262-0057 46.9 µM -1.08343870586427 0.116400339280843 no 2958 0.13930687166087 4175 883298 SGTC_1446 4239-0190 62 µM -1.08385950606714 0.11630850771637 no 2959 0.139213548163916 4187 1340085 SGTC_1930 st074634 34.3 µM -1.08414710702748 0.116245773908439 no 2960 0.139149789578504 4074 684253 YOR116C RPO31 SGTC_1190 1486-1332 13 µM -1.08446222016421 0.116177066496026 no 2961 0.139079954607305 4157 4150046 SGTC_515 4092-1064 102 µM -1.08776325043542 0.115459040278352 no 2962 0.138349818464612 4213 717353 SGTC_1986 st071812 45 µM -1.09013434123244 0.114945240339598 no 2963 0.137826985438946 4128 11838594 SGTC_1494 4358-1428 177 µM -1.0915059224897 0.114648771101421 no 2964 0.137525163644901 4214 1564571 SGTC_573 3702-0553 84.7 µM -1.09250521255012 0.114433116052138 no 2965 0.137305550298811 4132 1222756 SGTC_1485 3909-9022 254 µM -1.0938676726031 0.114139551423442 no 2966 0.137006509387857 4228 714516 SGTC_3268 9137683 49.47 µM -1.09530058172148 0.113831386530232 no 2967 0.13669248637163 4246 1953228 SGTC_463 ikarugamyin 104 µM -1.1007841103413 0.112657563037731 no 2968 0.135495314465827 4321 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1314 1222-0010 41.1 µM -1.10079621351366 0.112654981786636 no 2969 0.13549268005497 4198 3526027 SGTC_1842 st055362 61.2 µM -1.10288810568456 0.112209476973925 no 2970 0.135037880076835 4157 676032 SGTC_1003 4049-0218 100 µM -1.10388013189382 0.111998648463199 no 2971 0.134822569237907 4227 295161 SGTC_2705 st078069 42.8 µM -1.10390554740586 0.111993250802619 no 2972 0.134817056113729 4251 1530061 SGTC_2698 st077697 67.5 µM -1.10921161169397 0.110870436446117 no 2973 0.133669452267235 4174 3154499 SGTC_39 0986-0283 58.349 µM -1.10988829439895 0.110727825745226 no 2974 0.133523582618348 4285 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3067 9117431 49.47 µM -1.11134823342922 0.110420591827394 no 2975 0.133209242689215 4237 17150885 SGTC_736 0958-0254 92.6 µM -1.11735076966556 0.109163823365925 no 2976 0.131922187885892 4294 6812352 SGTC_2210 7115885 190.385 µM -1.11833025465176 0.108959725115649 no 2977 0.131712984967841 4285 2927039 SGTC_3221 9128209 49.47 µM -1.1184052925124 0.108944100569122 no 2978 0.13169696748148 4237 16460723 SGTC_860 0443-0016 25.1 µM -1.11935093748218 0.108747334347676 no 2979 0.131495226508922 4236 5337942 SGTC_2009 4012297 12.05 µM -1.1211815578334 0.108367152279286 no 2980 0.131105294086719 4202 45595307 SGTC_158 k038-0087 26.446 µM -1.123355760686 0.107916858889612 no 2981 0.130643215296601 4131 X158 SGTC_1747 st037496 66.6 µM -1.12498811119281 0.107579673808269 no 2982 0.130297036114243 4191 723305 SGTC_1391 3442-0225 151 µM -1.12576538376538 0.107419384244286 no 2983 0.130132420005128 4192 5227075 SGTC_2090 5301565 104.445 µM -1.12627735472578 0.10731389939883 no 2984 0.130024069941721 4216 2056344 SGTC_154 3389-1638 511.116 µM -1.1293074997816 0.106691106824581 no 2985 0.129384069118968 4223 5238686 SGTC_1019 4262-0212 3.4 µM -1.13050886162881 0.106444911707836 no 2986 0.12913093326926 4246 4677213 SGTC_208 k072-0098 12.366 µM -1.13091575998669 0.106361619080604 no 2987 0.129045274661143 4194 5948901 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.13221498178605 0.106095981759662 no 2988 0.128772031488618 4198 676296 Flavone; oxidizing agent. SGTC_3321 9137793 26.8275 µM -1.1323521425263 0.106067966036631 no 2989 0.128743208249979 4193 4904192 SGTC_2630 antimycin a 100 µM -1.13493875435516 0.105540638959045 no 2990 0.128200490347131 4166 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1144 3486-0183 12.5 µM -1.1402556273192 0.104462658708342 no 2991 0.127089909159492 4224 6744069 SGTC_841 0251-0215 91.2 µM -1.14122473933804 0.104267036740912 no 2992 0.126888205900312 4273 3888614 SGTC_3341 9147222 25.867 µM -1.1431314989826 0.103882919522151 no 2993 0.12649199896284 4242 1939759 SGTC_1454 4239-0054 42.6 µM -1.14322988931383 0.103863126647942 no 2994 0.126471577775508 4339 1340767 SGTC_2197 6588183 93.1375 µM -1.14441108057763 0.103625723604976 no 2995 0.126226597527326 4186 884136 SGTC_2734 clemastine 41.6 µM -1.14464243086469 0.103579271558528 no 2996 0.126178654006131 4293 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2468 5987765 72.9 µM -1.1457099836375 0.103365116960997 no 2997 0.125957585775771 4275 26772094 SGTC_213 1246-0773 967 nM -1.14798285777777 0.102910241980274 no 2998 0.125487820278135 4260 6251622 SGTC_781 4335-2806 94.4 µM -1.15178900508627 0.102151769782362 no 2999 0.124703893527998 4299 845254 SGTC_308 4092-1169 104 µM -1.15263167214915 0.10198439806901 no 3000 0.124530798786889 4174 2268590 YDL196W YDL196W SGTC_982 1491-0518 27.5 µM -1.15484960721907 0.101544822750424 no 3001 0.124076009277055 4160 3091256 SGTC_372 0155-0182 15.9 µM -1.15572950875183 0.101370816793859 no 3002 0.123895907070701 4142 771486 SGTC_402 epigallocatechin gallate 10 µM -1.15591023306628 0.101335104350523 no 3003 0.123858938266556 4183 65064 An antioxidant. SGTC_1393 3470-5649 58.2 µM -1.15622744879796 0.101272442372451 no 3004 0.123794067572284 4220 4108395 SGTC_617 3770-0098 35 µM -1.157315480299 0.101057729925996 no 3005 0.123571745578596 4161 5962639 SGTC_510 ag-490 170 µM -1.15944937210895 0.100637590990289 no 3006 0.123136530935709 4379 5328779 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.16014799073052 0.100500318186701 no 3007 0.122994278958751 4265 5106787 A p450 inhibitor. SGTC_2482 5981709 142.65 µM -1.16071485616823 0.100389034234201 no 3008 0.122878939121233 4182 877755 SGTC_714 4296-0578 26.1 µM -1.16222946167299 0.100092136247721 no 3009 0.122571135186933 4297 1589775 SGTC_571 k831-0106 44.2 µM -1.16404147241324 0.0997377828070848 no 3010 0.122203602642285 4125 4783639 SGTC_3051 9093778 49.47 µM -1.16622239009769 0.0993125030768308 no 3011 0.121762271116391 4325 17217378 SGTC_2606 farnesol 9.78 µM -1.16640674399136 0.0992766148656158 no 3012 0.121725016574097 4289 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_380 3970-0968 6 µM -1.16645221218309 0.099267765021087 no 3013 0.1217158295175 4136 2891601 SGTC_978 1416-0512 87.4 µM -1.16741371465038 0.0990807550155341 no 3014 0.121521667618632 4331 6814003 SGTC_599 1935-0052 86.5 µM -1.16988497650944 0.0986012828241928 no 3015 0.12102363026242 4250 9557311 SGTC_457 grayanotoxin iii 135 µM -1.17132301786945 0.0983230581392264 no 3016 0.120734481316363 4108 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1746 st038117 42 µM -1.1716779580577 0.0982544747335774 no 3017 0.12066318789447 4304 2898218 SGTC_1302 1159-0335 255 µM -1.17275410428426 0.098046750297301 no 3018 0.120447213921966 4274 649284 SGTC_1926 methyl fluorone black 53.6 µM -1.1759158521015 0.0974383119164959 no 3019 0.119814251810673 3932 72721 Reacts with homocysteine. SGTC_960 1222-0186 7.7 µM -1.17947174242082 0.0967573399497989 no 3020 0.11910519114859 4275 3126296 SGTC_3161 9100388 49.47 µM -1.18012798598989 0.0966320487602726 no 3021 0.118974657683887 4345 25236368 SGTC_578 3460-0051 92 µM -1.18201901882501 0.0962716759572714 no 3022 0.118599077251514 4326 2876744 SGTC_1280 0880-0253 10.1 µM -1.1830994229873 0.0960662280051757 no 3023 0.118384873257258 4252 6836607 SGTC_1785 bathophenanthroline 24 µM -1.18353799343494 0.0959829221936246 no 3024 0.118297999122668 4192 72812 An iron chelator. SGTC_300 r073-0011 5.04 µM -1.18406759954164 0.0958823951163184 no 3025 0.118193152297586 4275 2735780 SGTC_1667 st014849 34.6 µM -1.18523478334333 0.0956611197906695 no 3026 0.117962315400898 4345 5348460 SGTC_2202 7226349 200 µM -1.18625412894133 0.0954681792672952 no 3027 0.117760977890405 4235 844334 SGTC_1910 st062352 60.4 µM -1.18645562984448 0.095430073345361 no 3028 0.117721206954929 4170 2245730 SGTC_829 1635-0120 117 µM -1.18733309548037 0.0952642659689744 no 3029 0.117548129335857 4277 285054 SGTC_1683 st010134 710 nM -1.18869762584026 0.095006843586229 no 3030 0.11727933760638 4252 3818134 SGTC_1531 st059297 52.4 µM -1.19272287711981 0.0942504546636812 no 3031 0.116488961500971 4302 7566702 SGTC_2253 7938677 135.83 µM -1.19623101617485 0.0935948672681074 no 3032 0.115803210156967 4337 2301972 SGTC_869 0564-0080 44.1 µM -1.19980780259544 0.0929299244655657 no 3033 0.115106996581501 4295 6843321 SGTC_2911 7942208 15.64 µM -1.20203287378068 0.0925180382775409 no 3034 0.114675395855224 4321 1243384 SGTC_2429 5902844 64.44 µM -1.20401769778473 0.0921517657063188 no 3035 0.114291369129909 4292 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1651 st011928 86.1 µM -1.20560256225262 0.091860071938429 no 3036 0.113985385390059 4296 720198 SGTC_591 4299-0174 154 µM -1.2063576116353 0.0917213461087992 no 3037 0.11383981632511 4319 5509088 SGTC_2694 st077685 81.9 µM -1.20839816432142 0.0913472103495382 no 3038 0.113447072781239 4218 2838096 SGTC_509 pifithrin 175 µM -1.20984845964173 0.0910819870179716 no 3039 0.113168523666223 4372 4817 A p53 inhibitor. SGTC_9 0092-0002 10.449 µM -1.21121801366041 0.090832054016481 no 3040 0.112905930332294 4300 759368 SGTC_1168 k815-0004 80.5 µM -1.21286527356855 0.0905321164018324 no 3041 0.112590667218634 4267 642433 SGTC_229 benomyl 22.8748 µM -1.21331050220931 0.0904511743117564 no 3042 0.112505564557266 4313 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3245 9134821 49.47 µM -1.21422649252132 0.0902848172647557 no 3043 0.112330623292277 4307 17014901 SGTC_313 3474-0040 5.03 µM -1.21688779536899 0.0898027756152188 no 3044 0.111823454893031 4307 1043375 YIL048W NEO1 SGTC_835 0312-0010 67.2 µM -1.22194271972588 0.0888924497212172 no 3045 0.110864644475749 4307 1626196 SGTC_3134 9127454 49.47 µM -1.22530323837402 0.0882910773659949 no 3046 0.110230494358785 4362 24262820 SGTC_1990 st072050 59.8 µM -1.22567329940565 0.0882250398917822 no 3047 0.110160820955014 4299 17233948 SGTC_1888 azatryptophan 97.5 µM -1.22958725206096 0.0875288466163355 no 3048 0.109425853076799 4358 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1477 0139-0234 16 µM -1.23242594021055 0.0870264865500406 no 3049 0.108895007944781 4312 620880 SGTC_2908 7930301 100 µM -1.23619991952782 0.0863619477430487 no 3050 0.108192130307558 4280 2223178 SGTC_1241 0364-0022 50.8 µM -1.24331852126255 0.0851188140681058 no 3051 0.106875240883287 4312 4563895 SGTC_2280 7785178 200 µM -1.24343428914503 0.0850987087256474 no 3052 0.106853920657322 4309 2954328 SGTC_2972 9093619 59.92 µM -1.24574264171139 0.0846985610788186 no 3053 0.106429446664307 4275 25236256 SGTC_972 1319-0219 195 µM -1.24625554374564 0.0846098425885963 no 3054 0.106335296644651 4308 23903702 SGTC_2872 9044037 25.97 µM -1.24683309930639 0.0845100242043944 no 3055 0.106229350621528 4360 6465195 SGTC_1853 st056710 91.2 µM -1.24689174893038 0.0844998927881697 no 3056 0.106218596278469 4382 269167 SGTC_1803 st050068 52.4 µM -1.24923850150824 0.0840952508121984 no 3057 0.105788926874047 4372 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_67 0335-0847 266 µM -1.2503224681413 0.0839088382856237 no 3058 0.105590887025763 4416 4552207 YOR254C SEC63 SGTC_514 4466-0038 2.65 nM -1.25179039961717 0.0836568892321688 no 3059 0.105323124645425 4127 5722064 SGTC_1122 capsaicin 818.572 nM -1.25215844864241 0.0835938081873931 no 3060 0.105256066663922 4373 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_329 k048-0121 21.3 µM -1.25391511503096 0.0832932200929842 no 3061 0.104936430249043 4349 6832902 SGTC_1419 3993-2473 62.6 µM -1.25473497894904 0.0831532093173789 no 3062 0.104787491641067 4398 704026 SGTC_881 0833-0569 170 µM -1.25484243897674 0.0831348711517733 no 3063 0.104767981525891 4349 5418700 SGTC_2390 9097792 176.6 µM -1.25641398066515 0.0828670332734256 no 3064 0.104482957690663 4369 4497149 SGTC_2635 hydroquinidine 100 µM -1.25644655377654 0.0828614887128619 no 3065 0.104477055992684 4260 442912 An experimental heart treatment. SGTC_921 1561-0023 372 µM -1.25925509001285 0.0823844714572828 no 3066 0.103969104463857 4316 24050882 SGTC_2028 5153890 36.43 µM -1.25952783012897 0.0823382581503139 no 3067 0.103919872286064 4322 2830968 YPR165W RHO1 SGTC_263 alizarin 107.927 µM -1.2603212560338 0.0822039304160151 no 3068 0.103776747523834 4367 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_550 4123-0385 25.7 µM -1.26580001536398 0.081280873026789 no 3069 0.102792344804103 4358 5731123 SGTC_1839 st053978 48 µM -1.27142083054471 0.0803420305322005 no 3070 0.101789487961389 4368 3788398 SGTC_1902 st060212 70.5 µM -1.27146833757971 0.0803341305222746 no 3071 0.101781042293729 4339 688944 SGTC_20 0481-0013 4.944 µM -1.27287012886271 0.0801012888434439 no 3072 0.101532065318291 4390 182045 SGTC_2224 6650123 117.647 µM -1.27400390666492 0.079913338474603 no 3073 0.101331015826723 4355 2908370 SGTC_3239 9133757 49.47 µM -1.27550692025424 0.0796646929169926 no 3074 0.101064938152443 4387 17036923 SGTC_244 nsc-207895 1.295 µM -1.27760639204106 0.0793183548481995 no 3075 0.100694122814893 4117 42640 SGTC_1189 1431-2119 7.28 µM -1.28346077540431 0.0783586110946491 no 3076 0.0996653466314081 4346 3107275 SGTC_3196 9111891 49.47 µM -1.2838502934278 0.0782950688903843 no 3077 0.0995971710918499 4339 18891510 SGTC_2142 5622915 118.518 µM -1.28604167542741 0.0779383161066925 no 3078 0.0992142587159502 4360 5322196 SGTC_1394 3474-0001 65.7 µM -1.28604261367072 0.0779381636270992 no 3079 0.0992140950023477 4320 5017666 YIL048W NEO1 SGTC_114 0364-0001 490.298 µM -1.28652827184514 0.0778592667607108 no 3080 0.0991293792650588 4389 4003655 SGTC_1137 ixabepilone 100 µM -1.28748563638417 0.0777039170787109 no 3081 0.0989625364270846 4310 154225 A novel microtubule stabilizer. SGTC_1770 st043884 66.3 µM -1.28983153167916 0.0773242480108573 no 3082 0.0985545787068705 4365 670149 SGTC_345 1362-0200 395 µM -1.29260354105181 0.076877433238704 no 3083 0.098074107137025 4345 1419823 SGTC_2051 5263410 176 µM -1.29756641978232 0.0760823832057296 no 3084 0.0972181837687047 4321 227584 SGTC_1556 plumbagin 1.48 µM -1.29843976614453 0.0759431236611107 no 3085 0.097068130898439 4286 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2571 chrysanthemic acid 100 µM -1.29962123275702 0.075755041761766 no 3086 0.0968654093762896 4343 2743 An insecticide. SGTC_1995 st072814 61.1 µM -1.30001230930691 0.0756928631083784 no 3087 0.0967983751738939 4338 5769371 SGTC_2540 epiandrosterone 100 µM -1.30137114604758 0.0754771190213643 no 3088 0.0965657225841394 4407 441302 A steroid. SGTC_613 3914-0030 117 µM -1.30533002502942 0.0748512345788112 no 3089 0.0958902471921238 4085 1145395 SGTC_2984 9022109 38.96 µM -1.31052191001896 0.0740364274775612 no 3090 0.0950096685815819 4397 6459207 SGTC_724 3910-0327 137 µM -1.31257818078861 0.0737155991024317 no 3091 0.094662562949767 4411 2885483 SGTC_815 1582-0027 36.9 µM -1.31324046701916 0.0736124928909659 no 3092 0.0945509659831698 4392 3128206 SGTC_1660 st012960 28.1 µM -1.31515549928518 0.0733149766957788 no 3093 0.0942288237522292 4401 24207266 SGTC_1600 coumarin 106 71.1 µM -1.31573491054648 0.0732251418280292 no 3094 0.0941315162631941 4442 100336 A hepatotoxic, DNA x-linker. SGTC_395 anisomycin 6.25 µM -1.31668593026901 0.0730778734849878 no 3095 0.0939719608372318 4390 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_660 4031-1742 102 µM -1.31863842529359 0.0727762340854355 no 3096 0.0936450105574157 4271 6738706 SGTC_3036 9090181 49.47 µM -1.3206343985615 0.0724688640918152 no 3097 0.0933116487116414 4434 25236586 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.3244041353256 0.0718910574998685 no 3098 0.0926844309680704 4379 688667 SGTC_344 k064-0035 6.43 µM -1.32491552753491 0.0718129467340105 no 3099 0.0925995850851016 4330 5088750 SGTC_1522 st012842 45.6 µM -1.32588927036124 0.0716643958720031 no 3100 0.0924381887631426 4228 3491067 YOR116C RPO31 SGTC_3187 9109394 49.47 µM -1.33177764161997 0.0707711044676417 no 3101 0.0914666335421734 4392 17098090 SGTC_2786 7743617 45.45 µM -1.3351403361041 0.0702648211524281 no 3102 0.0909152099645145 4327 583674 SGTC_488 nitrendipine 139 µM -1.33534044910524 0.0702347804125193 no 3103 0.0908824728240378 4424 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3023 9089636 49.47 µM -1.34120533741065 0.0693587299881102 no 3104 0.0899268969686877 4459 17249241 SGTC_970 1315-0089 19.5 µM -1.34581869681771 0.0686755565224172 no 3105 0.0891804970781133 4363 6811083 YLR033W RSC58 SGTC_804 1595-0054 20.9 µM -1.3510453364263 0.0679078480031913 no 3106 0.0883404551754235 4373 761523 Stimulates phospholipase C. SGTC_40 0327-0103 19.753 µM -1.35610503673389 0.0671709897643781 no 3107 0.087532875278006 4243 409036 SGTC_1755 st041960 45.185 µM -1.35681039008503 0.06706876007105 no 3108 0.0874207326411243 4422 2257073 SGTC_2987 9018338 71.43 µM -1.36399299363617 0.0660345962508913 no 3109 0.0862848853973845 4417 5055682 SGTC_2036 5160441 105 µM -1.37181491540078 0.0649224817600106 no 3110 0.0850605314101558 4379 134534 YIL048W NEO1 SGTC_535 2293-4129 48.2 µM -1.37244267243127 0.0648338618845069 no 3111 0.0849628368415214 4421 396118 YIL048W NEO1 SGTC_1068 loratadine 26.9 µM -1.37327884977733 0.0647159654136088 no 3112 0.084832837565042 4467 3957 A H1 histamine antagonist. SGTC_2188 6126565 140.678 µM -1.37354258211501 0.0646788151413339 no 3113 0.0847918664343816 4318 874518 SGTC_733 4069-0007 56.1 µM -1.37792103898244 0.0640644673159498 no 3114 0.0841138342201248 4428 5717425 YNL287W SEC21 SGTC_1105 epirubicin 18.1 µM -1.3783200134037 0.0640087129247232 no 3115 0.0840522533859806 4454 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1124 fisetin 1.16336 µM -1.38143554460983 0.0635746320120934 no 3116 0.0835725416189036 4431 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2348 9022543 33.42 µM -1.38143870403254 0.0635741929814463 no 3117 0.0835720561953559 4427 3162678 YDL140C RPO21 SGTC_1285 0929-0069 65.5 µM -1.3836987626271 0.0632607412173707 no 3118 0.0832253563078137 4464 1206237 SGTC_1152 3909-8331 15.9 µM -1.38454439418427 0.0631437688114284 no 3119 0.0830959122275434 4398 16001939 SGTC_1080 nisoldipine 24.4 µM -1.38643169906025 0.0628833139133034 no 3120 0.0828075613283619 4436 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1524 corynanthine 62.1 µM -1.38737207642187 0.0627538512456365 no 3121 0.0826641675815001 4495 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_947 3447-0010 211 µM -1.3877876567695 0.0626967041140537 no 3122 0.0826008572518339 4383 748350 SGTC_172 1112-0046 2.638 µM -1.39386397437194 0.0618657640210805 no 3123 0.0816793424740702 4408 2802135 YIL048W NEO1 SGTC_3228 9131799 49.47 µM -1.39429071021585 0.0618077322143653 no 3124 0.0816149175327912 4460 17015818 SGTC_1047 2043-3044 82 µM -1.403192673026 0.0606068177725555 no 3125 0.0802796959497394 4416 669592 SGTC_2240 6690706 185.951 µM -1.40339709295793 0.0605794565437901 no 3126 0.0802492296979562 4331 805876 SGTC_919 tnp00227 403.569 nM -1.40712442108969 0.0600822532014785 no 3127 0.0796952488748382 4391 1269246 A methoxyflavone. YNL221C POP1 SGTC_2677 mitomycin C 100 µM -1.40770068637608 0.060005668850582 no 3128 0.0796098592543476 4515 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_723 4182-0001 115 µM -1.40842155595339 0.0599099745680705 no 3129 0.079503139993385 4455 744821 YLR208W SEC13 SGTC_3005 9076496 71.4286 µM -1.40855377469935 0.0598924357205319 no 3130 0.0794835777679445 4410 21368410 SGTC_2286 7945697 125 µM -1.41635363432556 0.0588648809391529 no 3131 0.0783359959146225 4432 1245733 SGTC_2486 5283202 22.39 µM -1.41654141325459 0.0588403145247664 no 3132 0.0783085239769348 4460 1377751 SGTC_1328 1441-0025 69.2 µM -1.41753595608874 0.0587103363318511 no 3133 0.0781631447974919 4428 4562601 SGTC_1782 st039423 80.636 µM -1.42208148627526 0.0581191413734648 no 3134 0.0775012983401469 4465 2068169 SGTC_2294 7971431 200 µM -1.42210169398887 0.0581165236264323 no 3135 0.0774983655518284 4431 5741572 SGTC_554 4483-2211 187 µM -1.4259958280339 0.0576137966494759 no 3136 0.0769347731557539 4495 747107 SGTC_94 0334-0113 514.748 µM -1.42775804970857 0.0573874234009168 no 3137 0.0766807556185771 4469 6795178 SGTC_785 1270-0111 65.3 µM -1.43058641740394 0.057025557728099 no 3138 0.0762743912503343 4377 6741994 SGTC_429 1112-0049 25.5 µM -1.43422526797938 0.0565626428144808 no 3139 0.0757539942758581 4419 2836170 SGTC_1572 epiandrosterone 68.9 µM -1.43439635680424 0.0565409509145904 no 3140 0.0757295933621151 4406 441302 A steroid. SGTC_3198 9112019 49.47 µM -1.43499638789492 0.0564649263637268 no 3141 0.0756440634542873 4500 45595555 SGTC_3066 9117245 49.47 µM -1.43654873949459 0.0562686156246842 no 3142 0.0754231289344443 4503 17176980 SGTC_2146 5545642 200 µM -1.43909772355469 0.0559474380952736 no 3143 0.0750614184648159 4408 825326 SGTC_1415 3966-0071 78.1 µM -1.44180468161792 0.055607940654155 no 3144 0.0746787409031779 4365 2893185 SGTC_2775 cyproheptadine 69.59 µM -1.44698629669134 0.0549626172950415 no 3145 0.0739503807845203 4468 2913 A selective serotonin reuptake inhibitor. SGTC_924 2046-0044 21.3 µM -1.44822924077932 0.0548087032885708 no 3146 0.0737764746807153 4441 3623589 SGTC_2988 9073640 71.4286 µM -1.44891918463543 0.0547234145685509 no 3147 0.0736800764266554 4486 9102229 SGTC_2333 9017922 200 µM -1.44894062252442 0.0547207661648941 no 3148 0.0736770826897617 4478 3163164 SGTC_1560 lithocholic acid 53.1 µM -1.45549655834833 0.0539155984633434 no 3149 0.0727659211650108 4412 9903 A bile acid which acts as a detergent. SGTC_2818 7996756 12.99 µM -1.4667408529514 0.0525564994093315 no 3150 0.0712232825094144 4495 2241621 SGTC_2651 TUB2.036 5 µM -1.46926379946093 0.0522553174803478 no 3151 0.0708806257976892 4384 15992207 YFL037W TUB2 SGTC_2875 9039966 71.43 µM -1.47093589359411 0.0520564641572761 no 3152 0.0706542272538509 4466 6463691 SGTC_2725 haloperidol 53.21 µM -1.47493222801223 0.0515836363216903 no 3153 0.0701153823962013 4443 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2586 curcumin 80 µM -1.47523130533448 0.0515483886603602 no 3154 0.0700751838631059 4373 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_971 1315-0384 26.7 µM -1.47764066254625 0.0512651327768975 no 3155 0.069751992236466 4498 6769120 SGTC_2754 granisetron 64.02 µM -1.47813110614754 0.0512076257823945 no 3156 0.0696863448082771 4474 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_744 1594-0068 283 µM -1.47993564650288 0.0509964760302175 no 3157 0.0694452107707151 4473 668392 SGTC_2961 9083290 32.55 µM -1.48372315561395 0.0505555524893762 no 3158 0.0689411903170014 4447 17741490 SGTC_2112 5488546 200 µM -1.48776942780136 0.0500878657933819 no 3159 0.068405855403542 4445 600757 SGTC_3229 9132204 49.47 µM -1.49937283142694 0.048765801132528 no 3160 0.0668884688495528 4592 17682924 SGTC_2120 5538279 151.968 µM -1.50085310199506 0.0485991672328636 no 3161 0.066696780228374 4468 2058197 SGTC_315 k915-0449 187 µM -1.50258625425243 0.0484046453258344 no 3162 0.0664728850985945 4524 20970215 YNL149C PGA2 SGTC_2018 5133068 143 µM -1.50572345036893 0.0480541233974969 no 3163 0.0660690907145145 4459 785362 SGTC_528 3492-0019 172 µM -1.50649962545104 0.0479677148270648 no 3164 0.0659694816039114 4496 2869262 SGTC_1829 berberine 14.4 µM -1.50875250099251 0.0477176151143277 no 3165 0.0656810216523026 4457 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3163 9099914 49.47 µM -1.5123030507405 0.047325576807515 no 3166 0.0652283926600519 4594 16268368 SGTC_2465 5809242 33.21 µM -1.51249149304363 0.0473048420669047 no 3167 0.0652044375757256 4580 2731748 SGTC_642 0335-0876 158 µM -1.51724216571117 0.0467845157868902 no 3168 0.0646027770170554 4544 6812350 SGTC_500 h-89 112 µM -1.51944825624566 0.046544455665014 no 3169 0.0643248515758167 4469 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.52142957003171 0.0463296986290917 no 3170 0.0640760365209332 4508 688798 SGTC_612 0302-0167 22.4 µM -1.52373484808321 0.0460808288166323 no 3171 0.0637874802697912 4507 235821 SGTC_1611 st001856 99.4 µM -1.5243392425691 0.046015758472469 no 3172 0.0637119945017109 4503 647478 SGTC_409 arachidonic acid 100 µM -1.52860275889089 0.0455588340377675 no 3173 0.0631814758359696 4521 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_837 0091-0265 12.5 µM -1.52898016833194 0.0455185631470467 no 3174 0.063134680176429 4506 759367 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.5312137841506 0.0452808142670295 no 3175 0.0628582825893807 4456 6857784 SGTC_1860 st056228 74.6 µM -1.53367268440194 0.0450202420961244 no 3176 0.0625550985081008 4494 688679 SGTC_1065 prochlorperazine maleate 2.48 µM -1.53470186987566 0.044911537160618 no 3177 0.0624285381679053 4543 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3311 9131146 2.8755 µM -1.5365971224174 0.0447119091241081 no 3178 0.0621959988410218 4455 4900406 YPR165W RHO1 SGTC_2062 5245942 200 µM -1.54037909618413 0.0443156875859121 no 3179 0.0617339868880072 4547 1376160 SGTC_1075 aripiprazole 15.2 µM -1.54163525845599 0.0441847125028569 no 3180 0.0615811262669186 4562 60795 An atypical antipschotic. YIL048W NEO1 SGTC_755 1995-0008 37.3 µM -1.5481722694006 0.0435081533026381 no 3181 0.0607904129950857 4491 689533 SGTC_504 lovastatin 124 µM -1.54939954590871 0.0433820713596779 no 3182 0.0606428514368024 4515 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_47 0149-0135 24.25 µM -1.55834590272002 0.0424718730471229 no 3183 0.0595756365435013 4539 5239155 SGTC_416 estradiol valerate 100 µM -1.55870725054287 0.0424354366911387 no 3184 0.059532842457213 4512 13791 A steroid. SGTC_1840 st055363 71 µM -1.56276905700618 0.0420276030622093 no 3185 0.0590534623831118 4550 676033 SGTC_2217 6934799 96.0675 µM -1.56677497371456 0.0416284944561348 no 3186 0.0585836495304446 4510 675606 SGTC_2567 aureobasidin a 60 nM -1.57331314022687 0.0409836979372728 no 3187 0.0578231640942817 4588 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2666 tannic acid 100 µM -1.57421938811851 0.0408949660875006 no 3188 0.05771836928196 4500 16134267 A thiamine antagonist. SGTC_2993 9054257 71.4286 µM -1.57558935804432 0.0407611265639636 no 3189 0.0575602351266504 4454 6470217 YGL055W OLE1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.57830932998328 0.0404964516886556 no 3190 0.0572472817725529 4553 6708784 An antioxidant flavonoid SGTC_616 4092-0450 108 µM -1.5810053201328 0.0402354889890652 no 3191 0.0569384106515902 4545 787165 SGTC_1943 st076331 65.2 µM -1.58237687087038 0.040103252687758 no 3192 0.0567817807782192 4527 24208415 SGTC_2816 7982706 58.44 µM -1.58299547077009 0.0400437268250644 no 3193 0.0567112483604067 4511 2981853 SGTC_1789 tunicamycin 25 nM -1.58539495797116 0.0398135109524847 no 3194 0.0564383130203205 4454 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_302 1094-0063 18.9 µM -1.59280990614964 0.0391088848747784 no 3195 0.0556014210813562 4533 5440289 SGTC_828 2074-0507 139 µM -1.59552648834944 0.0388532887039671 no 3196 0.0552972757517218 4584 X828 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.60865225155524 0.0376374216874034 no 3197 0.0538462009935824 4492 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_952 1185-0122 232 µM -1.61214133395615 0.0373194999448325 no 3198 0.0534655939663686 4514 678600 SGTC_271 rotenone 740 µM -1.61225411051271 0.0373092605702112 no 3199 0.0534533273776079 4585 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2251 lansoprazole 556 µM -1.61485027401827 0.037074179743659 no 3200 0.0531715614624766 4535 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_770 0389-1121 67.2 µM -1.61662396670508 0.0369142702291841 no 3201 0.0529797376374251 4585 6753108 SGTC_2484 5809818 12.04 µM -1.61770178444448 0.0368173739550421 no 3202 0.0528634406301751 4529 2870548 SGTC_221 trifluoperazine 10.304 µM -1.61889412946746 0.0367104240415127 no 3203 0.0527350221023566 4541 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1337 1486-1011 40.3 µM -1.6321512289477 0.035538333908441 no 3204 0.0513238160123602 4558 X1337 SGTC_3184 9108758 49.47 µM -1.65534312023656 0.033561754156218 no 3205 0.0489274583983051 4612 902885 SGTC_3331 9141060 1.957 µM -1.66779728207077 0.0325382309357234 no 3206 0.0476779878120307 4530 4906567 YPR165W RHO1 SGTC_1777 st045864 34.765 µM -1.67045420613333 0.0323232424744487 no 3207 0.0474147662858484 4593 4691462 SGTC_1966 st070145 16.1 µM -1.67277169562925 0.0321366782138259 no 3208 0.0471861244589419 4550 3748532 SGTC_2364 9055074 200 µM -1.67432345633965 0.0320122548044867 no 3209 0.0470335234988576 4578 6470630 SGTC_2979 9012552 45.46 µM -1.67537257744171 0.0319283596773105 no 3210 0.0469305767702228 4593 17100905 SGTC_2370 9071495 200 µM -1.68030514444253 0.0315363471875704 no 3211 0.0464489803279729 4601 21791103 SGTC_3256 9138902 49.47 µM -1.68114344440687 0.0314701210160762 no 3212 0.0463675277950545 4682 17228773 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.68150120385922 0.0314418928408498 no 3213 0.0463328014043306 4600 66535 A nucleotide analog. SGTC_1818 st052136 56.3 µM -1.68390491065767 0.0312527763045709 no 3214 0.0461000235829268 4228 674169 SGTC_1299 1079-1439 3.74 µM -1.6848433204782 0.0311792007829526 no 3215 0.046009402198529 4565 323161 SGTC_295 k015-0027 31 µM -1.6940790969144 0.0304626908689763 no 3216 0.0451251269035854 4631 3887424 SGTC_3206 9114350 49.47 µM -1.70062397249411 0.0299632427089848 no 3217 0.0445068098386076 4459 17087243 SGTC_2222 6885208 172.143 µM -1.70587936665061 0.0295671294217267 no 3218 0.0440152710692835 4617 609514 SGTC_1685 st024049 53.0905 µM -1.70598417502983 0.029559274150292 no 3219 0.0440055130095064 4608 1941139 SGTC_1205 4161-2785 76 µM -1.70732144864155 0.0294591989457699 no 3220 0.0438811608046161 4586 3498106 SGTC_1431 4049-0260 9.09 µM -1.71122258475729 0.0291688624748631 no 3221 0.0435200155036109 4623 3854841 SGTC_286 k060-0067 22.9 µM -1.72369280853897 0.0282566848004705 no 3222 0.042381656978413 4637 5985051 SGTC_230 MPP+ 141.667 µM -1.72591491263259 0.0280966601142185 no 3223 0.0421813607304741 4580 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2117 5521686 200 µM -1.72998704085641 0.0278053645231874 no 3224 0.0418162953008671 4601 803312 SGTC_428 3448-4153 16.5 µM -1.73113883814495 0.0277234298543199 no 3225 0.0417135023895857 4571 3834874 SGTC_3035 9091303 49.47 µM -1.73133689233906 0.0277093612919478 no 3226 0.041695847550801 4645 25237002 SGTC_3243 9134147 49.47 µM -1.73138907280983 0.0277056556998469 no 3227 0.0416911971152595 4685 24282180 SGTC_1015 4130-4525 82 µM -1.73931554223914 0.027147534674604 no 3228 0.0409896374741211 4600 1363237 SGTC_3169 9102970 49.47 µM -1.74058806762679 0.0270588131068506 no 3229 0.0408779053607821 4654 17027839 SGTC_2755 lomerizine 42.69 µM -1.74285549487708 0.0269013258447097 no 3230 0.0406794298703531 4544 3949 A calcium channel blocker. SGTC_1574 spiramycin 23.7 µM -1.74608625854849 0.0266782512603525 no 3231 0.0403979821099314 4581 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3000 9075062 71.4286 µM -1.7509593510341 0.0263447030031592 no 3232 0.0399764560825922 4590 17057871 SGTC_1865 st057639 52.2 µM -1.75979908781159 0.0257485462183851 no 3233 0.0392209389034097 4617 688818 SGTC_1473 k844-0725 134 µM -1.76281476597971 0.0255477678522472 no 3234 0.0389658680831095 4651 54682906 SGTC_3053 9095903 49.47 µM -1.76333902889519 0.0255129974905438 no 3235 0.0389216632237459 4701 17174018 SGTC_4 0960-0234 25.671 µM -1.76452728175583 0.025434336415016 no 3236 0.0388216231517466 4583 6821112 SGTC_906 1165-0455 526 µM -1.76700842055181 0.025270742433133 no 3237 0.0386134090504087 4591 3252859 SGTC_1688 st021091 57.6 µM -1.76721461917272 0.0252571864884246 no 3238 0.0385961461486463 4652 3656366 SGTC_3172 9105863 49.47 µM -1.77550329051801 0.0247172949253241 no 3239 0.0379074113591563 4716 2348785 SGTC_887 0885-0007 9.62 µM -1.77776276648976 0.0245718121370683 no 3240 0.0377214130355141 4631 5719458 SGTC_2712 st079126 47.7 µM -1.78369026922738 0.0241935648034922 no 3241 0.0372370040994841 4622 3152970 SGTC_2956 9076196 2.52 µM -1.78784639653157 0.0239312796295286 no 3242 0.0369003965345481 4609 16423868 SGTC_2300 7976697 71.57 µM -1.78803299205166 0.0239195602191898 no 3243 0.0368853425821459 4522 2236109 SGTC_1005 4092-0690 4.4 µM -1.79222856882997 0.0236573215795852 no 3244 0.0365481800587064 4626 1529343 SGTC_1581 himbacine 57.9 µM -1.7975929532526 0.023325554055311 no 3245 0.0361207679303219 4640 5281825 An alkaloid muscarinic receptor antagonist. SGTC_531 3788-1495 174 µM -1.79901181463084 0.023238460382418 no 3246 0.0360084059187752 4612 2896655 SGTC_2969 9091408 28.7 µM -1.80910063974652 0.0226270402434723 no 3247 0.0352176848620057 4569 4286311 SGTC_2675 theaflavin digallate 100 µM -1.80963513874121 0.0225950294829582 no 3248 0.0351761934998744 4583 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3319 9138450 16.7555 µM -1.81512447240081 0.0222684810645777 no 3249 0.0347523915659296 4586 2029690 SGTC_1852 st056254 31.4 µM -1.82218938750804 0.0218540728452862 no 3250 0.0342131271434349 4615 442583 SGTC_3350 9150499 3.57 µM -1.82348307805967 0.0217788984290939 no 3251 0.0341151288594141 4632 4910996 YPR165W RHO1 SGTC_1037 k284-1091 78.7 µM -1.82530584412018 0.0216733509977684 no 3252 0.0339774443844398 4619 3334711 SGTC_1673 st016611 27.3 µM -1.82656441073803 0.0216007260785235 no 3253 0.0338826442503648 4622 5226799 SGTC_1417 3966-0327 90.4 µM -1.82938804993533 0.0214385374454666 no 3254 0.0336707482642435 4694 651118 SGTC_2100 5377183 190 µM -1.84211898289419 0.020720005613971 no 3255 0.0327288738361761 4657 2844202 SGTC_2085 5307070 144.047 µM -1.85590997902645 0.0199647607234974 no 3256 0.0317331951874379 4592 2840351 SGTC_3046 9092212 49.47 µM -1.86264863768937 0.0196043040587574 no 3257 0.0312558582950972 4695 25236637 SGTC_339 3091-4833 71.4 µM -1.87888721652393 0.0187583285060234 no 3258 0.0301299473536432 4482 3240077 SGTC_2234 tolnaftate 200 µM -1.87978378792575 0.0187125392902378 no 3259 0.0300687754176837 4737 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1605 st000082 49.1 µM -1.88336663301703 0.0185305065956531 no 3260 0.0298253494964789 4634 1114022 SGTC_805 3852-0218 479 µM -1.90014266424387 0.0176981009859077 no 3261 0.0287072000540283 4650 6615355 SGTC_2992 9074591 71.4286 µM -1.90106501588533 0.0176532755130033 no 3262 0.028646748600514 4606 17741321 SGTC_431 k089-0097 107 µM -1.90343551881181 0.0175385154427868 no 3263 0.0284918700202247 4364 5499420 SGTC_3241 9133421 49.47 µM -1.91179938618437 0.0171386804152809 no 3264 0.0279509652760301 4731 17018221 SGTC_1780 st038448 24.544 µM -1.91569577085348 0.0169550894036836 no 3265 0.0277019155329059 4667 728868 YDL195W SEC31 SGTC_1754 st042065 16.137 µM -1.91578630635055 0.0169508435916346 no 3266 0.0276961507262775 4430 1126236 YIL048W NEO1 SGTC_309 k408-0051 1.48 µM -1.91593287377328 0.0169439719966762 no 3267 0.0276868202316258 4581 3640463 SGTC_1427 4048-4900 550 nM -1.92509583114644 0.0165190833747237 no 3268 0.027108685208491 4661 24132586 SGTC_2449 5812982 45.77 µM -1.93828129724415 0.0159236926277448 no 3269 0.0262944564576369 4605 776185 SGTC_407 eburnamonine 100 µM -1.94188941714116 0.0157640097038061 no 3270 0.0260752444175497 4548 3195 SGTC_2593 nobiletin 86.24 µM -1.94647254030813 0.0155631584729698 no 3271 0.0257990016643825 4646 72344 An anti-infammatory. SGTC_2017 5132927 60.65 µM -1.94726552400436 0.0155286304841164 no 3272 0.0257514548549493 4631 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1440 4100-1550 40 µM -1.96787682478798 0.0146539606151747 no 3273 0.0245411059712641 4701 742806 SGTC_223 busulfan 5 mM -1.97194965233827 0.0144862333232069 no 3274 0.0243076771629855 4680 2478 A DNA alkylator. SGTC_1870 st057514 26.5 µM -1.97261325522785 0.014459061967548 no 3275 0.0242698208268886 4673 5393161 SGTC_2343 7990716 14.84 µM -1.97775125848746 0.0142501664022426 no 3276 0.0239783872840676 4674 6456862 SGTC_2459 5811157 9.22 µM -1.98487648674293 0.0139647817119863 no 3277 0.0235791075076986 4643 2870684 YBR192W RIM2 SGTC_3059 1327-0034 3 µM -1.99382386011396 0.0136134045403158 no 3278 0.0230856535456895 4551 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1749 st037932 54.2 µM -1.99453542298537 0.0135857907826563 no 3279 0.0230467864086872 4655 594497 SGTC_765 1319-0117 244 µM -2.00435751344528 0.0132095341269627 no 3280 0.0225158885300278 4654 3487746 YGL099W LSG1 SGTC_1847 st056231 15 µM -2.005891385624 0.0131515961035338 no 3281 0.0224339187710068 4675 5393180 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.00729039321386 0.0130989438545379 no 3282 0.0223593757356273 4577 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2968 9090663 33.37 µM -2.01325962699483 0.0128763311748308 no 3283 0.0220436616451506 4638 25236811 SGTC_2455 5377712 9.75 µM -2.02190500066738 0.0125597205456886 no 3284 0.0215930835319286 4690 2243908 SGTC_1557 sumaresinolic acid 42.3 µM -2.03319090802696 0.0121565655767287 no 3285 0.0210166196348744 4670 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1422 4031-0024 15.5 µM -2.08010065620023 0.0105987310956823 no 3286 0.0187581507164714 4675 782427 SGTC_1514 1189-1591 158 µM -2.09042316927985 0.0102802708028328 no 3287 0.01828990170281 4694 767698 YMR146C TIF34 SGTC_1425 4048-4433 7.33 µM -2.09866223243977 0.0100321069892211 no 3288 0.0179233431002785 4747 23734946 SGTC_2349 9023730 187.07 µM -2.09937725377386 0.0100108188974343 no 3289 0.0178918290975377 4708 4126287 SGTC_1653 st012112 65 µM -2.10433964782487 0.00986415862036073 no 3290 0.0176744149442907 4696 720429 SGTC_1230 0170-0365 3.77 µM -2.11674798352604 0.00950562206754751 no 3291 0.0171406210556137 4705 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1800 st050079 29.0735 µM -2.11762779076979 0.00948063836445867 no 3292 0.0171033013254109 4564 3645560 SGTC_2291 7917025 104.35 µM -2.12310970927837 0.00932625912914106 no 3293 0.0168723297996843 4643 2964612 SGTC_2135 5326629 150.42 µM -2.1415282699746 0.00882355749389355 no 3294 0.0161157306173297 4693 5020077 SGTC_374 0880-0231 82.3 µM -2.1777004323551 0.00790500558368928 no 3295 0.0147141733553558 4614 6833587 SGTC_2266 7929956 200 µM -2.17930294638495 0.00786633250586227 no 3296 0.0146545852484232 4698 2967153 SGTC_3247 9135149 49.47 µM -2.20814684965749 0.00719815223570982 no 3297 0.0136170190278727 4733 8934436 YOR116C RPO31 SGTC_814 3342-0569 96 µM -2.23231746687065 0.00667730945889529 no 3298 0.0127969941282518 4752 4346283 SGTC_444 curcumin 90.4 µM -2.23349278605723 0.00665285463575338 no 3299 0.012758232760188 4646 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1515 3460-0031 42.1 µM -2.23404801721081 0.00664132952109242 no 3300 0.0127399569025446 4717 2876596 SGTC_1712 st032288 53.4 µM -2.26529023656157 0.00602060467757705 no 3301 0.0117474373961787 4555 2883011 SGTC_1028 k015-0029 4.8 µM -2.27420366865941 0.00585320857045745 no 3302 0.0114768718892887 4730 4588309 SGTC_369 0957-0393 4.5 µM -2.28890407724686 0.00558613888282378 no 3303 0.0110424631601282 4720 6997992 SGTC_412 gemfibrozil 100 µM -2.29213015365454 0.00552899809669476 no 3304 0.0109490669354376 4722 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_951 1171-0579 82.7 µM -2.30565476176726 0.00529505991289434 no 3305 0.0105649653796978 4678 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_293 4049-0273 38.5 µM -2.31251146068363 0.005179854952436 no 3306 0.0103747572403768 4671 1380311 SGTC_1495 4469-0029 237 µM -2.32182270585461 0.00502698189954856 no 3307 0.0101212420582009 4746 793680 SGTC_1547 harmine 94.2 µM -2.34237624209682 0.00470367251609699 no 3308 0.00958069380929236 4678 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1724 st037281 8.293 µM -2.349600085152 0.00459452529450495 no 3309 0.00939679541564561 4708 574124 YDL195W SEC31 SGTC_649 1123-0311 367 µM -2.40875467792441 0.00378244828527247 no 3310 0.00800352683775576 4680 693629 YIL048W NEO1 SGTC_2259 7964009 200 µM -2.41805931668196 0.00366715314032474 no 3311 0.00780176649944424 4759 313134 SGTC_1303 1160-0052 261 µM -2.45317413591998 0.00325991286323943 no 3312 0.00708008858135075 4725 3562476 SGTC_1573 oleylamine 1.06 µM -2.45412949927409 0.00324942518290154 no 3313 0.00706130562690094 4745 5356789 An amine of the fatty acid oleic acid. SGTC_2153 5569715 200 µM -2.45645864830781 0.00322398359282378 no 3314 0.00701569747969778 4768 2054701 SGTC_2274 7947094 46.08 µM -2.45860148810504 0.00320073551182799 no 3315 0.00697396738143779 4732 2971028 SGTC_2293 7624732 200 µM -2.45935088039109 0.00319264088061568 no 3316 0.00695942536360763 4688 894453 SGTC_2990 9074105 71.4286 µM -2.4749844140921 0.00302792102132755 no 3317 0.00666209952073206 4722 6502001 SGTC_245 methotrexate 289.6 µM -2.47689269442845 0.00300834814457156 no 3318 0.00662658704190388 4729 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2470 5664817 21.68 µM -2.49190042650215 0.0028583467914255 no 3319 0.00635308264740306 4787 2859561 SGTC_3201 9113999 49.47 µM -2.55061320748324 0.00233418814975677 no 3320 0.00537667970240494 4735 16649224 SGTC_729 4092-0585 94.1 µM -2.59828520315574 0.00197440606861671 no 3321 0.00468453204573105 4770 2169061 SGTC_1707 st032323 6.317 µM -2.61219724324624 0.0018793460342416 no 3322 0.00449811671246781 4629 3132057 YMR211W DML1 SGTC_2450 5739737 12.93 µM -2.62165016118717 0.00181714891478661 no 3323 0.0043752601938468 4768 2262825 SGTC_1957 st077035 62.4 µM -2.6616260554451 0.00157429032837299 no 3324 0.00388821085449799 4767 705593 SGTC_1076 itraconazole 331 nM -2.69404427022884 0.00139949240315181 no 3325 0.00352953940030409 4781 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2452 5863136 48.41 µM -2.69593798881161 0.00138985149928552 no 3326 0.00350953661582735 4750 2184096 SGTC_151 3013-0144 2.285 µM -2.7063494404158 0.00133792202427168 no 3327 0.003401371077558 4606 906558 YHR107C CDC12 SGTC_1838 st055369 84.5 µM -2.71684866651921 0.00128735609253147 no 3328 0.0032953367633368 4780 676036 SGTC_524 r073-0010 27.8 µM -2.77294063090073 0.00104560929461261 no 3329 0.00277761273124816 4754 2772106 SGTC_1857 st056007 79.3 µM -2.77899006495482 0.00102219335743642 no 3330 0.00272640964095111 4776 619834 SGTC_2575 plumbagin 510 nM -2.84935237627385 0.000783015100940103 yes 3331 0.00219041653153935 4738 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1658 st012944 20 µM -2.90846383791116 0.000623142622624195 yes 3332 0.00181604590085653 4712 24207260 SGTC_2779 methotrexate 400 µM -2.9783126754847 0.000473273181969218 yes 3333 0.0014492006962521 4778 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1947 st076332 61.6 µM -3.006728482149 0.000422474083661657 yes 3334 0.00132037758659045 4753 24208416 SGTC_2021 4019055 173 µM -3.01056963187271 0.000416009136757977 yes 3335 0.00130379075918203 4700 44827708 YER133W GLC7 SGTC_2136 5328288 199.296 µM -3.04455870976759 0.000362673144593966 yes 3336 0.00116510972134078 4777 262395 SGTC_1461 k072-0203 53.8 µM -3.15738872617329 0.000227772579380717 yes 3337 0.000795944896601289 4655 5418714 SGTC_2389 9091542 195.52 µM -3.16772495119006 0.000218107868158833 yes 3338 0.000768183993842844 4783 3626624 YOL127W RPL25 SGTC_1236 0330-0013 258 µM -3.26922617796961 0.00014153601589023 yes 3339 0.000539210300470559 4802 4617066 SGTC_1310 1188-0297 994 nM -3.31311669376262 0.000116957723162413 yes 3340 0.000461312381050493 4788 1588352 SGTC_2145 5634607 200 µM -3.37063898975109 9.07759641307741e-05 yes 3341 0.000374970321917829 4805 308662 SGTC_2098 5376439 882.5 nM -3.3938137072254 8.18750818617848e-05 yes 3342 0.000344632817257241 4809 2844116 SGTC_768 0384-0033 77.3 µM -3.42657659581407 7.06838017736473e-05 yes 3343 0.000305620671713347 4799 3965305 YMR134W ERG29 SGTC_1718 roemerine 11.9335 µM -3.48630552997007 5.38931497315074e-05 yes 3344 0.000244870657913089 4632 235224 An aporphine alkaloid with mutagenic activity. SGTC_2092 5303694 80.6725 µM -3.64735144036103 2.53988565852993e-05 yes 3345 0.000132478705907265 4806 1963699 SGTC_299 1273-0059 1.44 µM -3.72377496392717 1.75832343699015e-05 yes 3346 9.81329423051607e-05 4715 2848077 SGTC_2912 7964298 10.93 µM -3.90772762549093 7.05172858213676e-06 yes 3347 4.65841259717329e-05 4802 2975850 SGTC_1218 1348-1416 30.7 µM -4.14883578218992 2.00292339473131e-06 yes 3348 1.67085206989983e-05 4807 6787668 SGTC_1787 fluconazole 80 µM -5.15774081962104 4.84684256092139e-09 yes 3349 1.24973635529573e-07 4737 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1463 k081-0032 34.1 µM -6.19061169456749 2.83609071217855e-12 yes 3350 2.99655910419771e-10 4653 977755 SGTC_1462 k081-0014 26.5 µM -9.37508009235653 8.28616240732962e-26 yes 3351 3.45616347473973e-21 4669 3270634