SGTCid condition conc unit YOR342C|YOR342C.score YOR342C|YOR342C.strain.pval YOR342C|YOR342C.strain.significant YOR342C|YOR342C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2398 5228213 48.84 µM 6.97393792556089 1.34635157623827e-11 yes 1 1.54095054379077e-12 4 80771 YMR134W ERG29 SGTC_146 3448-8650 53.125 µM 5.21912087607923 3.08915249653069e-07 yes 2 8.98872050373521e-08 74 2891488 YIL048W NEO1 SGTC_2329 6138490 200 µM 4.35481481201089 1.59384875252453e-05 yes 3 6.65897292022824e-06 18 720019 SGTC_2583 asiatic acid 100 µM 4.10407878898369 4.42705190026653e-05 yes 4 2.02964558032612e-05 34 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1707 st032323 6.317 µM 4.07071800291384 5.05072766402801e-05 yes 5 2.3434228703617e-05 53 3132057 YMR211W DML1 SGTC_627 1391-0720 175 µM 4.06704906571017 5.12416801744791e-05 yes 6 2.38061105444395e-05 12 997839 SGTC_2952 9073731 13.78 µM 3.96542369716337 7.60784758252751e-05 yes 7 3.6632843673301e-05 44 16457353 SGTC_1663 st014140 55.4 µM 3.86052145050134 0.000113333030689133 yes 8 5.65726535044086e-05 18 4207120 SGTC_3349 9149703 23.001 µM 3.85606138505282 0.000115245554799653 yes 9 5.76142820145677e-05 14 4910494 SGTC_3299 9121982 43.1275 µM 3.7716808000352 0.000157657737531511 yes 10 8.10758013627455e-05 38 17594604 YPL160W CDC60 SGTC_1361 1608-0041 5.61 µM 3.74176910735126 0.000175920504999309 yes 11 9.13646823489049e-05 23 X1361 SGTC_3052 9092717 49.47 µM 3.58058632835632 0.000313369497941848 yes 12 0.000171412025206499 44 25237534 SGTC_1677 st019204 53.9 µM 3.5658468571231 0.000329990434903822 yes 13 0.000181341562408978 30 3945625 SGTC_58 0957-0393 9 µM 3.48573996543083 0.000435580121986734 yes 14 0.000245388911157937 429 6997992 SGTC_1500 4488-1866 171 µM 3.4682338403962 0.000462485096873517 yes 15 0.000261945600409982 35 2900003 SGTC_347 4534-1311 26.2 µM 3.46592286675736 0.000466149673291339 yes 16 0.000264207425315191 23 2862016 SGTC_2705 st078069 42.8 µM 3.46040884932883 0.00047500235165854 yes 17 0.000269677899309211 15 1530061 SGTC_1866 st057638 64 µM 3.45823546164788 0.000478534287308772 yes 18 0.000271862976400674 15 688802 SGTC_14 0354-0009 295 µM 3.45580769885418 0.000482508356496574 yes 19 0.000274323294140824 42 1713507 SGTC_2400 5203494 178.7 µM 3.43410538372321 0.000519415797082266 yes 20 0.000297256506092843 35 6777674 SGTC_2786 7743617 45.45 µM 3.37534800690366 0.000632851838506999 yes 21 0.000368612009636549 52 583674 SGTC_1901 st060216 58.6 µM 3.29555562665071 0.000823661788567621 yes 22 0.000491136273051214 48 688792 SGTC_2407 paclitaxel 400 µM 3.2691096453656 0.000897759592814076 yes 23 0.00053943242950085 66 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_7 0192-1582 4.227 µM 3.26601798345967 0.000906810820688269 yes 24 0.000545356612215855 103 252616 SGTC_139 0099-0334 718.624 µM 3.23635624798842 0.000998010374173406 yes 25 0.000605330937397797 70 97690 SGTC_864 0469-0573 172 µM 3.18077780365798 0.00119190494356064 no 26 0.000734401188323477 48 689425 SGTC_3253 9135987 49.47 µM 3.1569904527007 0.00128497424186017 no 27 0.000797032827202374 32 4182430 SGTC_1137 ixabepilone 100 µM 3.15687415402898 0.00128544515594453 no 28 0.000797350768766441 76 154225 A novel microtubule stabilizer. SGTC_198 3454-2873 16.191 µM 3.14098073953125 0.00135130503722229 no 29 0.000841915527758418 38 710957 SGTC_3021 9087658 49.47 µM 3.13481619599959 0.00137766937007114 no 30 0.000859809098074094 19 25237042 SGTC_462 ag-879 158 µM 3.10810295675849 0.00149743207701424 no 31 0.000941462300976675 69 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1513 0337-0559 19 µM 3.0996869215643 0.00153708615874669 no 32 0.00096862648028357 47 775073 SGTC_349 k015-0014 24 µM 3.07436009448569 0.00166226540278982 no 33 0.00105477319472652 58 2196908 SGTC_2933 9026794 32.47 µM 3.07065887751556 0.00168131705040091 no 34 0.00106793509047117 71 17586027 SGTC_136 0097-0015 404.482 µM 3.03094832356801 0.00189860031848108 no 35 0.00121893483902579 61 4861337 SGTC_3054 9094397 49.47 µM 2.97282889816602 0.00226278370065963 no 36 0.00147534444186245 90 2598354 SGTC_2890 9046729 58.44 µM 2.96488759600999 0.0023171808904204 no 37 0.00151396770991994 56 903329 SGTC_2711 st079103 59.1 µM 2.93158839063079 0.00255840271656635 no 38 0.0016861669171774 34 54693780 SGTC_1659 st012954 42.1 µM 2.93107793795972 0.00256227090311815 no 39 0.00168894011862909 44 24207262 SGTC_2756 carbadox 75.1 µM 2.91906392945919 0.00265485225429488 no 40 0.0017554210757473 126 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2730 imipramine 71.33 µM 2.8948724970971 0.00285049643167137 no 41 0.00189656284598108 88 3696 A tricyclic antidepressant. SGTC_26 0302-0163 425.158 µM 2.89290775370598 0.00286694318236341 no 42 0.00190846690635734 48 3100915 SGTC_3254 9136651 49.47 µM 2.88160291279911 0.00296324911772511 no 43 0.00197829002472589 67 16454030 SGTC_2071 5230951 39.92 µM 2.87855344768298 0.0029897220355879 no 44 0.00199751789135314 62 1799272 SGTC_1019 4262-0212 3.4 µM 2.87046891251405 0.00306093965910414 no 45 0.00204931748272741 147 4677213 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.8563621413577 0.00318887494877251 no 46 0.00214263026531418 101 688664 SGTC_826 1683-5028 118 µM 2.85228211989187 0.00322676356100332 no 47 0.00217032788672986 67 722377 SGTC_261 5-fluorouridine 15.376 µM 2.81423669317321 0.00360004529263038 no 48 0.00244466068309162 77 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1231 0242-0792 125 µM 2.80389328422762 0.00370801672179484 no 49 0.00252448066777633 77 3707635 SGTC_197 4544-0043 41.561 µM 2.80356267530766 0.00371151524437117 no 50 0.00252707039453591 119 896523 SGTC_3316 9136639 10.545 µM 2.79332326695441 0.00382134563820337 no 51 0.00260847638774267 66 4903665 SGTC_919 tnp00227 403.569 nM 2.78947968705273 0.00386331902904128 no 52 0.00263964040143945 114 1269246 A methoxyflavone. YNL221C POP1 SGTC_143 4032-1194 15.74 µM 2.77588751741867 0.00401508457143786 no 53 0.00275256253561869 162 1806963 SGTC_2855 9016525 58.44 µM 2.77585767887664 0.00401542352916455 no 54 0.00275281515484485 87 43811474 SGTC_1680 diphenhydramine 100 µM 2.76409525905092 0.00415105417226339 no 55 0.00285404362892222 94 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_557 1315-0110 16.2 µM 2.75332800910392 0.00427878762731225 no 56 0.0029496378962001 93 6833801 SGTC_2258 7960471 200 µM 2.74840699038189 0.00433832774454951 no 57 0.00299428113807473 60 2974708 SGTC_793 0488-0545 106 µM 2.70081796295477 0.00495344987544884 no 58 0.00345845927099111 86 292548 SGTC_2172 5754775 163.918 µM 2.6930704130631 0.00506063450460176 no 59 0.00353986576995007 89 2263357 SGTC_704 1310-0270 142 µM 2.67063471196864 0.00538276608330325 no 60 0.00378539930044877 119 5718033 SGTC_3208 9114115 49.47 µM 2.66970893924772 0.00539644146249427 no 61 0.00379585117828284 121 650895 SGTC_3117 9124945 49.47 µM 2.65047418649116 0.00568764828537064 no 62 0.00401894346550025 60 17592065 SGTC_2849 9019321 12.99 µM 2.61457826129913 0.00626861131832518 no 63 0.00446688454723992 118 16489627 SGTC_798 1287-0182 476 µM 2.59969079589989 0.00652458316797118 no 64 0.00466538962210109 110 1649755 SGTC_2792 7535235 81.82 µM 2.58437153637703 0.00679758745851841 no 65 0.00487783198305628 112 1281891 SGTC_1705 st027868 56.3335 µM 2.58040649593966 0.0068698722191196 no 66 0.00493420383739434 80 292948 SGTC_61 0978-8327 98.565 µM 2.57834401337233 0.00690774008765939 no 67 0.00496375549338527 112 6150059 YHR072W ERG7 SGTC_1565 sinapyl alcohol 95.1 µM 2.57330837856697 0.00700097141014073 no 68 0.00503657049500786 120 5280507 A phenol propionate derived from cinnamic acid. SGTC_1319 1306-0155 43.7 µM 2.52431446670851 0.00796763225129781 no 69 0.00579620891603891 152 3122360 SGTC_2179 6298986 200 µM 2.5038815635076 0.00840427211142403 no 70 0.00614195733207387 98 738374 SGTC_3026 9090633 49.47 µM 2.49596701768851 0.00857896396495346 no 71 0.00628071403033784 117 25236842 SGTC_706 4262-0057 46.9 µM 2.48949153687588 0.00872425361554886 no 72 0.00639629820986888 141 883298 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.4865852422265 0.00879016024463489 no 73 0.00644878334619859 128 115019 SGTC_1835 st008666 49.2 µM 2.48005178263135 0.00893991632474498 no 74 0.00656816518929838 102 690455 SGTC_177 1327-0068 8.361 µM 2.47514686430022 0.00905380834376873 no 75 0.00665906983754136 159 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_331 k048-0133 24.5 µM 2.47358032920564 0.00909044997655798 no 76 0.00668833640726105 85 6813582 SGTC_457 grayanotoxin iii 135 µM 2.45967039757991 0.00942154280397336 no 77 0.00695323325133435 209 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_823 0417-1665 178 µM 2.44217496823117 0.00985292024668337 no 78 0.00729953457376969 130 3429856 SGTC_1053 3366-3204 134 µM 2.44034831654906 0.00989893857493968 no 79 0.00733655326083794 136 3632071 YPR165W RHO1 SGTC_274 sirtinol 40.1 µM 2.43774616327035 0.00996481795119305 no 80 0.00738957392403315 115 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_421 streptovitacin 30 mM 2.40499898138327 0.0108271770916837 no 81 0.00808625543118969 139 91467 include heat shock SGTC_1670 st016595 4.04 µM 2.399969528041 0.0109652195775685 no 82 0.00819821835475864 115 597879 SGTC_3189 9110682 49.47 µM 2.38445187010823 0.0114008246729521 no 83 0.00855229263098737 136 17122418 SGTC_856 0433-0016 11.3 µM 2.38402052099637 0.0114131451002903 no 84 0.00856232370976759 121 3911780 SGTC_3204 9114183 49.47 µM 2.38311572588578 0.0114390259334308 no 85 0.00858339837560472 137 17027248 SGTC_2289 7946404 165.07 µM 2.38220743496539 0.0114650580255299 no 86 0.00860460022149822 230 1246120 YPR165W RHO1 SGTC_90 0870-0863 4.608 µM 2.36069413293558 0.0120968623930611 no 87 0.00912038415309392 177 1738164 SGTC_178 4092-0806 87.505 µM 2.36008996974435 0.0121150328625129 no 88 0.00913525169682393 260 2169044 SGTC_2959 9079155 11 µM 2.3585725845657 0.0121607732469297 no 89 0.00917268585929176 130 16189457 SGTC_3330 9141424 71.43 µM 2.35403436024024 0.0122984688525362 no 90 0.0092854471872424 135 27261020 SGTC_151 3013-0144 2.285 µM 2.35184229427096 0.0123654614038161 no 91 0.00934034660440919 161 906558 YHR107C CDC12 SGTC_145 3737-0113 38.366 µM 2.34338717396245 0.0126268310261243 no 92 0.00955477051047074 229 6849351 SGTC_553 k007-0256 45.7 µM 2.31666825625611 0.0134844518631264 no 93 0.010260905024123 156 6287000 SGTC_1049 3226-0134 66 µM 2.29829062755012 0.0141031213639494 no 94 0.010772626766645 178 5702385 SGTC_1524 corynanthine 62.1 µM 2.29678947193585 0.0141547204589482 no 95 0.0108153912200012 145 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1037 k284-1091 78.7 µM 2.27605908375572 0.0148840869415479 no 96 0.0114212367836752 126 3334711 SGTC_2589 lobaric acid 100 µM 2.26750504404263 0.0151943361705694 no 97 0.0116796955606979 167 73157 A novel microtubule depolymerizer. SGTC_1121 fusaric acid 630.51 nM 2.25848597939121 0.0155274523224497 no 98 0.0119576888577374 168 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1867 st057372 64 µM 2.25474715589942 0.0156673714384522 no 99 0.0120746019608262 138 688837 SGTC_3270 9137563 49.47 µM 2.2518658380996 0.0157759366124258 no 100 0.0121653757728686 125 17015724 SGTC_3216 9129716 49.47 µM 2.24545465472704 0.0160198208454557 no 101 0.0123694800669117 156 8056934 SGTC_797 k781-0471 270 µM 2.24241270545055 0.0161366638308537 no 102 0.0124673557017582 156 23738129 SGTC_663 1486-0733 13.9 µM 2.22432735653115 0.0168465140576639 no 103 0.0130632137138976 219 722445 YPR165W RHO1 SGTC_1225 1216-0074 20.6 µM 2.21775810739622 0.0171108875593246 no 104 0.0132856649576244 166 4241466 SGTC_140 0062-0056 502.533 µM 2.20262089349132 0.0177335991912476 no 105 0.0138107400212476 180 3758964 SGTC_3200 9114385 49.47 µM 2.19721051536584 0.0179608124894158 no 106 0.0140027074776558 178 17018030 YLR208W SEC13 SGTC_2145 5634607 200 µM 2.18808019171017 0.018349877645788 no 107 0.0143318807553331 123 308662 SGTC_2431 5490079 200 µM 2.17757842793865 0.0188062391532913 no 108 0.014718718510989 200 5722345 SGTC_700 3453-2283 142 µM 2.16791911184117 0.0192344826850932 no 109 0.0150824207290628 208 565664 SGTC_439 amiodarone 34.4 µM 2.16736738618674 0.0192591915505157 no 110 0.0151034260084623 276 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_92 0063-0024 660.874 µM 2.15945607736073 0.0196164744233761 no 111 0.0154074006906991 177 3594437 SGTC_1397 3532-0190 20.1 µM 2.1585868741461 0.0196560695211286 no 112 0.0154411159880747 118 5322280 SGTC_2567 aureobasidin a 60 nM 2.1542241502296 0.0198558326525154 no 113 0.0156112989130436 287 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1177 0983-0204 23.6 µM 2.14942472161765 0.0200775794871766 no 114 0.0158003737501492 163 766818 SGTC_263 alizarin 107.927 µM 2.14653959774413 0.0202118883422474 no 115 0.0159149765409063 284 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1787 fluconazole 80 µM 2.13831684723942 0.0205988618469295 no 116 0.0162455180610585 264 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1407 3909-7909 12.3 µM 2.13434491028503 0.0207880231752814 no 117 0.0164072787719939 184 4411780 SGTC_196 k015-0023 18.111 µM 2.13388303648729 0.0208101148226799 no 118 0.0164261782057456 180 5211998 SGTC_199 4063-0024 41.6 µM 2.13280728037922 0.0208616458306207 no 119 0.016470269392039 134 306215 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.12529456546092 0.0212245406851719 no 120 0.0167810207329073 207 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1701 st028638 40.4 µM 2.12264176429471 0.0213539509348382 no 121 0.016891941209584 185 3490878 SGTC_2025 5147754 141 µM 2.11485644766609 0.0217375961677412 no 122 0.0172210920563073 143 315777 YLR208W SEC13 SGTC_1128 3448-9350 235 µM 2.11471180066737 0.021744778828476 no 123 0.0172272589903856 199 619386 SGTC_991 3996-0057 64.7 µM 2.10849247609299 0.0220555103998894 no 124 0.0174942064440869 177 715343 SGTC_537 1334-0398 209 µM 2.09524903223776 0.0227296860633485 no 125 0.0180744303163124 207 5846986 SGTC_1302 1159-0335 255 µM 2.08894979063358 0.0230564035055198 no 126 0.0183561215629712 163 649284 SGTC_343 4130-2827 29.8 µM 2.08830254230416 0.0230901967392095 no 127 0.0183852761404244 214 1118244 SGTC_2186 6124449 200 µM 2.08506077974046 0.0232600793588512 no 128 0.0185318918906364 191 3834182 YLR033W RSC58 SGTC_237 nikkomycin 200 µM 2.08418219263453 0.0233063019805777 no 129 0.0185717989510036 199 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2003 4023581 200 µM 2.08205093249139 0.0234187492637298 no 130 0.0186689088670866 211 16641307 SGTC_2777 climbazole 1.536 µM 2.07141411621054 0.0239868044652666 no 131 0.0191600564169927 239 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_355 1311-2252 105 µM 2.06745285197904 0.024201292634983 no 132 0.0193457512501022 220 5338538 SGTC_2229 7354935 190 µM 2.05559924822105 0.0248527666783043 no 133 0.0199105801653074 131 318112 SGTC_2948 9070189 9.45 µM 2.05559264403237 0.0248531337038559 no 134 0.0199108987165964 199 6473636 YDL196W YDL196W SGTC_2902 5787006 60.46 µM 2.05464955796821 0.0249055920861001 no 135 0.0199564326465435 204 591003 SGTC_3197 9113331 49.47 µM 2.05079983721393 0.0251206936786714 no 136 0.0201432217147181 244 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2582 agaric acid 100 µM 2.04561205425518 0.0254130199794061 no 137 0.0203972772690643 649 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1783 st039459 87.517 µM 2.04214966262857 0.0256097034189935 no 138 0.0205683439492378 235 729761 SGTC_277 nystatin 15.5 µM 2.0375758093037 0.0258714764893546 no 139 0.0207961866628486 223 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_74 000s-0487 160.283 µM 2.0250259787851 0.0266012567437738 no 140 0.0214323483529668 224 677548 SGTC_1671 st016596 74.5 µM 2.02406205581785 0.0266580136171124 no 141 0.0214818835629595 214 2829167 SGTC_1050 3232-1156 69.3 µM 2.01735503769129 0.0270557371346161 no 142 0.0218292379229152 219 700529 SGTC_1933 st074711 15.9 µM 2.01679077594398 0.0270894222889561 no 143 0.0218586759767824 246 17250958 SGTC_2402 5553605 200 µM 2.01610057449045 0.0271306733383673 no 144 0.0218947300001861 233 6758546 SGTC_2261 9010538 184.68 µM 2.014025890845 0.0272549859764001 no 145 0.0220034076392819 176 6457250 SGTC_1403 3909-7815 62.9 µM 2.01342033396285 0.027291359698127 no 146 0.0220352141060877 164 6615483 SGTC_1668 st014914 51.6 µM 2.00369158770164 0.0278813042091091 no 147 0.0225515539821005 186 2839556 SGTC_1615 st002656 86.5 µM 1.98984222589366 0.028739413095852 no 148 0.0233041591391241 204 1584458 SGTC_610 4215-0184 155 µM 1.9800931035961 0.0293565492099864 no 149 0.0238465339710761 227 5605015 SGTC_712 r015-0009 80.6 µM 1.9798856048558 0.0293698029089545 no 150 0.0238581921480436 189 6813872 YLR060W FRS1 SGTC_1665 st014639 11.4 µM 1.97968082881734 0.0293828875699547 no 151 0.0238697020484012 257 981133 YIL048W NEO1 SGTC_2759 disulfiram 3.38 µM 1.9723050814253 0.0298574155971929 no 152 0.0242873949547152 242 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_22 0964-0034 14.468 µM 1.96996735445491 0.0300091364071816 no 153 0.0244210560538026 285 138402 SGTC_815 1582-0027 36.9 µM 1.96777745460955 0.0301518425028024 no 154 0.0245468246723395 215 3128206 SGTC_3265 9137266 49.47 µM 1.96691377022582 0.0302082794744198 no 155 0.0245965763697647 157 17224265 SGTC_866 0495-0101 262 µM 1.96159658078997 0.0305576601533864 no 156 0.024904735337203 211 635694 SGTC_3173 9105693 49.47 µM 1.96131049685932 0.0305765525829389 no 157 0.0249214067711991 250 17096658 SGTC_2147 5545932 89.7195 µM 1.960750129617 0.030613586185258 no 158 0.0249540890800561 193 797404 SGTC_166 k072-0058 166.424 µM 1.94549424686806 0.0316361770716802 no 159 0.0258577607364851 261 5846229 SGTC_576 1073-0113 22.7 µM 1.94371964316993 0.0317569393853153 no 160 0.0259646342645628 366 5439563 SGTC_1899 st063254 59.6 µM 1.940393761728 0.0319842923619436 no 161 0.026165927079704 196 3093813 SGTC_1234 0326-0494 15.5 µM 1.9373829793324 0.0321912631161255 no 162 0.0263492728285696 211 1547813 SGTC_2997 9067075 71.4286 µM 1.93045391640446 0.0326717909254394 no 163 0.026775309970509 278 27209819 SGTC_531 3788-1495 174 µM 1.92154675177812 0.0332981727498059 no 164 0.0273314071299333 245 2896655 SGTC_1450 4112-4260 37.6 µM 1.91817767686461 0.0335376608545246 no 165 0.0275442428828873 249 1633175 SGTC_1456 k015-0012 13 µM 1.91581731881145 0.0337062883127526 no 166 0.0276941762518255 298 2989616 SGTC_2629 bisabolol 100 µM 1.91413870893232 0.0338266346962498 no 167 0.0278012173290513 271 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1988 st071872 53.4 µM 1.91003174997447 0.0341225703147884 no 168 0.0280645627325488 210 16414116 SGTC_1940 st075990 51.1 µM 1.90198210977601 0.0347087792236055 no 169 0.0285867467451517 281 1084979 SGTC_2280 7785178 200 µM 1.90150220746022 0.0347439873718615 no 170 0.028618131819711 212 2954328 SGTC_661 1304-0007 33.6 µM 1.90115845508347 0.034769224869879 no 171 0.0286406304521864 230 3117130 SGTC_256 clotrimazole 625 nM 1.89824142171766 0.034983993038166 no 172 0.0288321432952497 269 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_194 1486-1323 56.904 µM 1.88554864869951 0.0359312174021067 no 173 0.0296779014293702 232 5178754 SGTC_2006 4011487 200 µM 1.88364057742585 0.036075411143064 no 174 0.0298068046161556 349 45595294 SGTC_1902 st060212 70.5 µM 1.87550363697247 0.0366956518271162 no 175 0.0303617348070467 247 688944 SGTC_658 3253-0951 102 µM 1.87044810980821 0.0370853849399481 no 176 0.0307108082150682 355 1184878 SGTC_2523 spermine 47.74 µM 1.86846214063341 0.0372394068932156 no 177 0.0308488412399711 244 1103 A DNA binding polyamine. SGTC_1731 st035964 63 µM 1.86801781445588 0.037273938085828 no 178 0.0308797939360848 279 6739575 SGTC_3286 9117135 37.221 µM 1.86549229061535 0.0374707085944628 no 179 0.0310562159084754 253 3438150 SGTC_3319 9138450 16.7555 µM 1.86188197455782 0.0377534706018451 no 180 0.031309864178593 236 2029690 SGTC_2022 5136654 200 µM 1.85835263827207 0.0380315713133457 no 181 0.0315594766642676 274 1713771 SGTC_423 5-fluorouracil 457 µM 1.85649325642428 0.0381787555998184 no 182 0.0316916416704325 273 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2068 5226020 147 µM 1.85043400852089 0.038661617746534 no 183 0.032125510580022 319 1810509 SGTC_476 mead acid 10 µM 1.84992439254361 0.0387024549309191 no 184 0.0321622238185307 165 5312531 An omega 9 fatty acid. SGTC_345 1362-0200 395 µM 1.84987823104507 0.0387061557369257 no 185 0.0321655510485148 248 1419823 SGTC_540 1187-0821 17.3 µM 1.84887928397196 0.0387863128100746 no 186 0.0322376228215664 262 847520 SGTC_1581 himbacine 57.9 µM 1.84589132004068 0.0390268790965739 no 187 0.0324539936236768 312 5281825 An alkaloid muscarinic receptor antagonist. SGTC_976 1348-1067 47.6 µM 1.84168359805768 0.0393677087615828 no 188 0.0327607223788602 298 5310671 YGL099W LSG1 SGTC_2536 dehydroabietamide 32.04 µM 1.84131405426723 0.0393977575080237 no 189 0.0327877746716564 293 3983547 SGTC_2835 9006588 71.43 µM 1.83878934198463 0.0396035492261815 no 190 0.0329730882414853 298 2345538 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.83274626381081 0.0400996780464481 no 191 0.0334201568871494 289 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_973 1325-0077 65.9 µM 1.83224217216248 0.0401412904862317 no 192 0.0334576741832413 276 2835149 SGTC_1062 mesoridazine 14.2 µM 1.83136762966753 0.0402135666255997 no 193 0.0335228447431 285 4078 A neuroleptic. SGTC_1661 st013063 9.66 µM 1.82947971297054 0.0403699530096128 no 194 0.0336638878591144 293 721395 SGTC_3269 9137823 49.47 µM 1.82760503757942 0.0405257308645678 no 195 0.0338044246061857 233 17682936 SGTC_1272 0839-0021 27 µM 1.82676843448184 0.0405954064600085 no 196 0.0338672969016124 277 5027250 SGTC_2670 beta-carotene 100 µM 1.82666686539491 0.0406038721480484 no 197 0.0338749365532721 174 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2815 7968870 71.43 µM 1.82539564060205 0.0407099487902392 no 198 0.033970673345087 321 2977326 YHR190W ERG9 SGTC_1380 2291-0730 164 µM 1.82451346105651 0.040783693867907 no 199 0.0340372415851407 271 2999191 SGTC_1971 st069429 63.5 µM 1.82374377129838 0.0408481239611898 no 200 0.0340954090655198 224 1246522 YGL099W LSG1 SGTC_398 bronopol 33.3 µM 1.81948869712698 0.0412058043420986 no 201 0.0344184528390423 289 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_605 1315-0399 119 µM 1.81427466224837 0.04164755227337 no 202 0.0348177252180819 309 24020461 SGTC_1125 tnp00248 1.32998 µM 1.80828183260861 0.0421600121281525 no 203 0.0352813239649522 384 24207736 SGTC_1614 st002383 48.6 µM 1.79807816150986 0.0430442814768258 no 204 0.0360823112147414 280 1947235 SGTC_971 1315-0384 26.7 µM 1.79672969788073 0.0431622547336995 no 205 0.0361892709399222 300 6769120 SGTC_2459 5811157 9.22 µM 1.79471836884882 0.0433387053401049 no 206 0.0363492911999239 272 2870684 YBR192W RIM2 SGTC_2240 6690706 185.951 µM 1.79318941753838 0.0434732270197577 no 207 0.0364713208146316 242 805876 SGTC_3247 9135149 49.47 µM 1.78947843035529 0.0438011328031215 no 208 0.0367688990980823 237 8934436 YOR116C RPO31 SGTC_1607 st000305 50.6 µM 1.78712746613183 0.0440098962707291 no 209 0.0369584445952837 287 5457690 SGTC_1160 4092-0570 10.5 µM 1.78698697865056 0.0440223967931467 no 210 0.036969796585682 320 4994975 SGTC_401 neomycin 50 µM 1.78380345178682 0.0443064341468827 no 211 0.0372278042500126 245 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2154 5570129 200 µM 1.78169801283233 0.0444950935542541 no 212 0.0373992455675344 309 673366 SGTC_1455 4262-0120 131 µM 1.77680223718739 0.0449362857295255 no 213 0.0378003918379818 306 1529587 SGTC_3095 9117207 49.47 µM 1.77431519073063 0.0451617557838052 no 214 0.0380055146272134 212 17015229 SGTC_1048 3161-0300 24.5 µM 1.77075797191766 0.0454858264342741 no 215 0.038300478804557 312 2165101 SGTC_2858 9025781 8.96 µM 1.76492009748454 0.0460217202672564 no 216 0.0387885977423052 430 4894980 YPL153C RAD53 SGTC_982 1491-0518 27.5 µM 1.76302335711626 0.0461969212007873 no 217 0.0389482751778007 262 3091256 SGTC_3124 9127567 49.47 µM 1.75977278175931 0.0464984203857239 no 218 0.0392231698751227 268 17592030 SGTC_2032 5185112 25.99 µM 1.75689291065972 0.0467668533688413 no 219 0.039468032124661 260 5718189 SGTC_2624 nerol 100 µM 1.75472089017993 0.0469701287853484 no 220 0.0396535304864079 266 637566 A natural product oil. SGTC_3317 9138495 8.753 µM 1.75448568008865 0.0469921841203976 no 221 0.0396736607482608 316 17020139 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.75250454483639 0.0471782822393715 no 222 0.0398435445306888 304 94937 An inhibitor of serotonin biosynthesis. SGTC_13 0199-0087 65 µM 1.75178913533166 0.0472456293046398 no 223 0.0399050365469169 286 4589825 SGTC_1376 2910-0861 41.3 µM 1.74541572402514 0.0478490147500709 no 224 0.0404562652835037 334 1112859 SGTC_2728 chlorpromazine 9.18 µM 1.74121657965171 0.0482499177529332 no 225 0.0408228110636447 191 2726 A thorazine and dopamine antagonist. SGTC_1683 st010134 710 nM 1.74039757279709 0.0483284227116895 no 226 0.0408946157209225 330 3818134 SGTC_1936 st074407 74.3 µM 1.73669784990996 0.0486843294480489 no 227 0.0412202587401866 365 809813 SGTC_753 1322-0200 289 µM 1.73259958685926 0.0490810175988631 no 228 0.041583431375796 306 5403907 SGTC_2888 9058547 12.99 µM 1.73048561417418 0.0492866449790003 no 229 0.0417717746445548 239 16476514 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.72598319916855 0.0497268901495623 no 230 0.0421752176641934 305 6708760 SGTC_2377 9073351 62.6 µM 1.7201770305442 0.0502992413633318 no 231 0.0427001334694162 322 7337946 YHR072W ERG7 SGTC_2239 6685329 187.64 µM 1.71968677200816 0.0503478086838766 no 232 0.0427446968068538 340 805680 SGTC_2121 5257820 149.641 µM 1.71756506022141 0.0505584264324338 no 233 0.0429379889620671 328 791256 SGTC_2215 7188065 200 µM 1.70691991648695 0.0516257620182137 no 234 0.0439184692076461 236 940217 SGTC_1150 3909-7983 10.9 µM 1.70048884818681 0.0522792045682635 no 235 0.0445195061380113 367 23965914 SGTC_2466 5983409 37.09 µM 1.69738772148388 0.0525966397626926 no 236 0.0448116911931021 312 2879657 SGTC_2403 6032726 181.2 µM 1.69724082553052 0.0526117140779536 no 237 0.0448255697937598 345 2881040 SGTC_3118 9124250 49.47 µM 1.69274117348061 0.0530751271249554 no 238 0.0452523721982657 285 1504786 SGTC_2977 9011197 71.43 µM 1.6892263120646 0.0534393647361283 no 239 0.0455880342286546 267 2704722 SGTC_1709 st033179 39.1045 µM 1.6862063432373 0.0537538972440489 no 240 0.0458780312802791 352 573381 SGTC_3180 9109287 49.47 µM 1.68386365920614 0.0539988982695664 no 241 0.046104010485473 297 18891271 SGTC_3273 9137859 49.47 µM 1.68341928335754 0.0540454712773082 no 242 0.0461469764332658 261 2377234 SGTC_747 3448-8087 38.7 µM 1.67956906986784 0.0544503269634514 no 243 0.0465205949021946 355 5168703 SGTC_2083 5306046 65.942 µM 1.67205991564609 0.0552468242917523 no 244 0.0472562539245489 370 539837 SGTC_2543 pimpinellin 60.67 µM 1.66510414085679 0.0559928081304095 no 245 0.047945990375548 327 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_293 4049-0273 38.5 µM 1.65916131381585 0.0566364306269715 no 246 0.0485416454056751 299 1380311 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.65216591701884 0.0574015018433251 no 247 0.0492503661842667 376 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1909 st060837 51.5 µM 1.65087036553867 0.0575440817781599 no 248 0.0493825240603731 373 678937 SGTC_1400 3771-8998 51.5 µM 1.6395726601527 0.0587992688476831 no 249 0.0505470257629428 304 670767 SGTC_1133 3473-0247 50 µM 1.63541062763861 0.0592670543615277 no 250 0.0509814980048411 403 711311 SGTC_3011 9081274 71.4286 µM 1.63452892756355 0.0593665253219198 no 251 0.0510739186495598 370 6625322 SGTC_3170 9103054 49.47 µM 1.63220160324723 0.0596297163552205 no 252 0.0513185115805837 308 16432970 SGTC_1761 st044296 37 µM 1.63124673161121 0.0597379644681894 no 253 0.0514191341488919 361 1826700 SGTC_122 0236-0016 402.397 µM 1.62904928085982 0.0599876611957192 no 254 0.051651293445011 428 6808838 SGTC_2318 6029776 164 µM 1.6275103128064 0.0601630205401172 no 255 0.0518143800627725 377 818325 SGTC_2440 5628896 157.78 µM 1.62582794892132 0.0603551781566504 no 256 0.0519931304929423 330 5522048 SGTC_1737 st035557 69.7 µM 1.62031783935957 0.0609879005542224 no 257 0.0525820093639831 306 5716916 SGTC_2417 cerulenin 830 nM 1.62015055458589 0.0610071905509388 no 258 0.0525999699489694 321 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_255 tunicamycin 200.472 nM 1.61736240128267 0.0613294016762588 no 259 0.0529000383587895 391 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2484 5809818 12.04 µM 1.61326088982217 0.0618058047243197 no 260 0.0533439198309905 353 2870548 SGTC_612 0302-0167 22.4 µM 1.61234586267769 0.0619124810071718 no 261 0.0534433492353436 440 235821 SGTC_89 0302-0250 142.109 µM 1.61055966861492 0.0621211342162281 no 262 0.0536378651697001 390 4203518 YLR208W SEC13 SGTC_3058 9093861 49.47 µM 1.61046838466322 0.0621318122139694 no 263 0.0536478210040784 371 17217477 SGTC_2033 5192550 145 µM 1.60867503925782 0.0623418804438425 no 264 0.0538437082520179 331 182073 SGTC_500 h-89 112 µM 1.60118121552081 0.0632256873984883 no 265 0.0546683940521362 381 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_332 4112-0506 40.9 µM 1.59561019128521 0.0638890222301436 no 266 0.0552879253776005 361 2790355 SGTC_98 0074-0023 107.663 µM 1.59402738792808 0.0640784685755467 no 267 0.0554649503788479 398 3563821 SGTC_3030 9087619 49.47 µM 1.59299288231125 0.064202524769434 no 268 0.0555808939000972 352 25236973 SGTC_160 3453-0671 289.699 µM 1.59278993102307 0.0642268842405502 no 269 0.0556036623532275 405 5322268 SGTC_708 3448-5400 146 µM 1.5924691079943 0.0642654060610921 no 270 0.0556396694747532 407 3462195 SGTC_3287 9117173 37.0625 µM 1.59028136092794 0.0645285718522586 no 271 0.055885699051765 281 2789709 SGTC_1754 st042065 16.137 µM 1.58605435791448 0.0650394118573576 no 272 0.056363489641029 567 1126236 YIL048W NEO1 SGTC_1194 1488-0194 225 µM 1.58434688605789 0.0652466503683055 no 273 0.05655740082772 423 1391452 SGTC_959 1222-0044 107 µM 1.58275348990511 0.0654405051149369 no 274 0.0567388306617927 381 6083612 SGTC_47 0149-0135 24.25 µM 1.57881575254152 0.0659214916061734 no 275 0.0571891621670807 345 5239155 SGTC_2920 7982904 15.77 µM 1.56885463396383 0.0671504517644529 no 276 0.0583409073443292 338 6456808 SGTC_574 1315-0397 40 µM 1.56337810878659 0.0678336290354157 no 277 0.058981843034768 482 6794277 SGTC_3347 9188721 44.724 µM 1.56070177225292 0.0681694393537873 no 278 0.059297066462559 342 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_529 4076-0302 30.3 µM 1.55989776889458 0.068270571010278 no 279 0.0593920209089206 400 5816522 SGTC_3348 9149464 3.537 µM 1.55799274538855 0.0685106567809781 no 280 0.059617483928456 374 1951442 SGTC_2906 7926292 26.41 µM 1.55786239743815 0.06852710801286 no 281 0.0596329353301755 404 2966319 SGTC_1870 st057514 26.5 µM 1.55710246239361 0.0686230801913636 no 282 0.0597230802597067 384 5393161 SGTC_1578 josamycin 24.2 µM 1.55647785833774 0.0687020390116331 no 283 0.0597972518818865 351 5282165 A P450 substrate. SGTC_931 2812-0076 566 µM 1.55571850584643 0.0687981262875322 no 284 0.0598875220290713 408 3450959 SGTC_927 2425-1185 123 µM 1.55361993296687 0.0690642153022011 no 285 0.0601375508881363 377 730375 SGTC_3071 9117417 49.47 µM 1.54866492060544 0.0696956338652275 no 286 0.0607311453918658 297 45595590 YGL055W OLE1 SGTC_508 roscovitine 141 µM 1.54786672477477 0.0697977624523678 no 287 0.060827193764312 338 160355 A CDKinase inhibitor. SGTC_676 falcarinol 140 µM 1.54648518547363 0.0699748015838489 no 288 0.0609937175992085 426 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3234 9132280 49.47 µM 1.54557106384873 0.0700921326846772 no 289 0.0611040970150214 412 17612295 SGTC_1461 k072-0203 53.8 µM 1.54533147245153 0.0701229101995928 no 290 0.0611330532809349 377 5418714 SGTC_2603 homopterocarpin 100 µM 1.5405302713587 0.0707418583175197 no 291 0.061715574928759 453 101795 A weak amylase inhibitor. SGTC_2087 5276107 200 µM 1.53377466236146 0.0716198574295436 no 292 0.0625425492189707 367 144405 SGTC_1962 st076595 64.5 µM 1.5336844892658 0.0716316331471473 no 293 0.062553645714825 419 279619 SGTC_3303 9125618 40.5795 µM 1.5320693740092 0.0718428029436165 no 294 0.0627526581615543 495 22695467 SGTC_2049 5262831 67.185 µM 1.53017050505978 0.0720916826264674 no 295 0.062987265034507 399 763417 SGTC_487 nimodipine 119 µM 1.52984124782214 0.0721349046505683 no 296 0.0630280144625755 269 4497 L-type voltage-gated calcium channels inhibitor SGTC_8 0354-0001 70 µM 1.52976279065303 0.0721452067546949 no 297 0.0630377274822273 511 4993152 SGTC_3152 9099253 49.47 µM 1.523397378819 0.0729848035665401 no 298 0.0638296587042739 534 25236131 SGTC_1417 3966-0327 90.4 µM 1.52335407001354 0.0729905414962938 no 299 0.0638350732048248 444 651118 SGTC_297 0986-0032 24 µM 1.52050058285205 0.0733693577632979 no 300 0.0641926061851861 351 2847425 SGTC_1097 itavastatin 7.23 µM 1.51325672464456 0.0743377733687215 no 301 0.0651072302576038 417 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_814 3342-0569 96 µM 1.51181565336537 0.0745315858043058 no 302 0.0652903830575012 458 4346283 SGTC_1408 3909-7976 48.8 µM 1.51010952397252 0.0747615447918519 no 303 0.065507739852776 459 24152374 SGTC_119 0121-0043 24.815 µM 1.50343606480713 0.0756662229760205 no 304 0.0663633161871398 621 1092378 SGTC_1444 4112-3581 28 µM 1.50333108572878 0.0756805206533285 no 305 0.0663768439144868 397 2877249 SGTC_1351 1496-0003 46.5 µM 1.4998434074023 0.0761566975995745 no 306 0.0668274851476644 423 3891978 SGTC_2249 haloperidol 116.36 µM 1.4994992964814 0.0762038028078729 no 307 0.0668720755410516 563 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2135 5326629 150.42 µM 1.49859693160009 0.076327432499569 no 308 0.0669891146154194 405 5020077 SGTC_2508 celastrol 40.54 µM 1.49801662748611 0.0764070184288112 no 309 0.0670644652375832 362 122724 Celastrol is a natural product and antioxidant. SGTC_3284 9108171 64.8615 µM 1.48990471836424 0.0775261477078627 no 310 0.0681246453829913 377 8687505 SGTC_2968 9090663 33.37 µM 1.48898900843085 0.0776532580440852 no 311 0.0682451315774833 426 25236811 SGTC_2522 biochanin a 4.94 µM 1.487585688205 0.0778483608482232 no 312 0.0684300950294506 381 5280373 A possible chelator. SGTC_385 1494-0393 12.4 µM 1.48165699447294 0.0786767313582621 no 313 0.0692157927611065 436 3090647 SGTC_1724 st037281 8.293 µM 1.47911965915099 0.0790332879962268 no 314 0.0695541684253057 467 574124 YDL195W SEC31 SGTC_2064 5220758 200 µM 1.47625709159166 0.0794370152521426 no 315 0.0699374441556153 483 788518 SGTC_2696 st077691 74.316 µM 1.47553633300667 0.0795389142673107 no 316 0.0700342038171021 405 757133 SGTC_348 k064-0012 10.7 µM 1.46744820663747 0.0806891846254503 no 317 0.0711270844567261 398 5066323 SGTC_1227 3909-8010 46.6 µM 1.46678463251358 0.0807841109982763 no 318 0.0712173257173797 416 15982272 SGTC_1292 0kpi-0043 232 µM 1.46593032151637 0.0809064470142355 no 319 0.0713336352089986 427 3333905 SGTC_1850 st056238 17 µM 1.45724933082216 0.0821574928056765 no 320 0.0725237839384191 500 5393177 SGTC_1743 st037606 46.3785 µM 1.45418584654893 0.0826024426210721 no 321 0.0729473939525415 436 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_717 1532-0246 73.2 µM 1.45308943990138 0.0827621280358479 no 322 0.0730994613384764 467 9561992 SGTC_1364 1653-0028 37.6 µM 1.44831143856177 0.0834607295221778 no 323 0.0737649850344743 461 5718652 SGTC_1745 st081495 74 µM 1.44581328600537 0.0838277494306701 no 324 0.074114789305122 522 13842402 YBL026W LSM2 SGTC_2099 5377090 177.372 µM 1.44515373967097 0.0839248496624991 no 325 0.0742073535016343 475 2243829 SGTC_1096 rimcazole 32.2 µM 1.44447993497542 0.0840241362465242 no 326 0.0743020099439898 409 18528119 A dopamine reuptake inhibitor. SGTC_2062 5245942 200 µM 1.44428976312696 0.0840521744328184 no 327 0.0743287420629912 466 1376160 SGTC_1075 aripiprazole 15.2 µM 1.44344914673505 0.0841761957491379 no 328 0.0744469940014263 521 60795 An atypical antipschotic. YIL048W NEO1 SGTC_518 1021-0119 62.6 µM 1.44235059986642 0.0843384781233003 no 329 0.0746017461902871 463 1097762 SGTC_428 3448-4153 16.5 µM 1.44158493518445 0.0844517243826205 no 330 0.0747097504095667 408 3834874 SGTC_142 0335-0849 62.6745 µM 1.44142926342341 0.0844747630909417 no 331 0.074731723967181 588 3889043 YPR107C YTH1 SGTC_288 1315-0019 35.1 µM 1.43887822050345 0.0848529778223586 no 332 0.0750925146270405 471 6811474 SGTC_916 4466-0038 42 nM 1.43049643534051 0.0861045910100597 no 333 0.0762872940902563 601 5722064 YGL116W CDC20 SGTC_3151 9099821 49.47 µM 1.42890161419669 0.0863442943545533 no 334 0.0765162567197208 415 17174189 SGTC_910 3454-3003 490 µM 1.42715474479521 0.0866074229756388 no 335 0.0767676478237178 491 820824 SGTC_905 2-aminofluorene 215 µM 1.42621646785285 0.0867490015807389 no 336 0.0769029337820796 493 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2758 dehydroepiandrosterone 69.35 µM 1.42499689321207 0.0869332842030437 no 337 0.0770790495848244 501 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_121 0557-0495 61.343 µM 1.41803805328025 0.0879903913123074 no 338 0.0780898276005619 640 3104427 SGTC_604 1000-0114 314 µM 1.41677112642112 0.0881838753740911 no 339 0.0782749270230665 503 1572745 SGTC_2983 9022671 12.99 µM 1.41602286674424 0.0882982978655456 no 340 0.0783844047743119 432 6405161 SGTC_3002 9075603 71.4286 µM 1.41167966716597 0.0889646378232961 no 341 0.0790221514439236 488 20105405 SGTC_2368 9071271 200 µM 1.40988703208373 0.0892407552142071 no 342 0.0792865211959008 473 27209959 SGTC_1452 4194-0072 190 µM 1.40932942003319 0.0893267734017211 no 343 0.0793688916886227 516 1343545 SGTC_2235 salicylic acid 500 µM 1.40900831494775 0.089376335599726 no 344 0.0794163547361278 430 338 A COX inhibitor and kinase inhibitor. SGTC_302 1094-0063 18.9 µM 1.40840304083659 0.0894698145736842 no 345 0.0795058796604068 408 5440289 SGTC_3101 9120531 49.47 µM 1.40558828095957 0.0899054836586445 no 346 0.0799232089740084 499 24824904 SGTC_2675 theaflavin digallate 100 µM 1.40556113170293 0.0899096934893189 no 347 0.0799272422986353 481 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3116 9124943 49.47 µM 1.40367198681771 0.0902029888449231 no 348 0.0802082739598058 449 41905195 YPL160W CDC60 SGTC_2717 st081029 62.2815 µM 1.40184057779828 0.0904879984039455 no 349 0.0804814291002546 440 5292846 SGTC_884 0851-0618 334 µM 1.39535918778833 0.0915020227678013 no 350 0.0814537759656875 510 9642473 SGTC_3144 9087057 49.47 µM 1.39473522706858 0.0916000851127573 no 351 0.0815478489155759 474 17249618 SGTC_839 0122-0028 230 µM 1.39239232317609 0.0919689936539679 no 352 0.0819018139386074 558 759448 SGTC_1017 4239-0030 168 µM 1.39223721170668 0.0919934559434667 no 353 0.0819252889210659 525 1149593 SGTC_949 1165-0505 146 µM 1.38415205163287 0.0932752289981534 no 354 0.0831559507733069 533 6244267 SGTC_291 SEC14.278 35.5 µM 1.38280725475735 0.0934896988136916 no 355 0.0833619869604232 504 1068044 SGTC_66 0109-0187 42.4 µM 1.3825347282255 0.0935332060197354 no 356 0.0834037874439976 469 759417 SGTC_2204 7233102 200 µM 1.38232985999472 0.093565921832731 no 357 0.0834352207785657 411 2172480 SGTC_556 4058-0063 51.5 µM 1.38110689436341 0.0937613954414717 no 358 0.0836230480402959 540 6615692 SGTC_558 k064-0027 21.3 µM 1.38077290229674 0.0938148316801012 no 359 0.0836743988759446 499 5088526 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.38060704733596 0.0938413755881639 no 360 0.0836999076568153 485 641818 YHR062C RPP1 SGTC_1253 0550-0034 176 µM 1.38001688805987 0.0939358713444735 no 361 0.0837907225574266 468 5969915 SGTC_519 k048-0011 62.8 µM 1.37960019441521 0.094002634228485 no 362 0.0838548887806877 486 6836379 SGTC_2661 dactinomycin 12.96 µM 1.370086107685 0.0955365264157301 no 363 0.0853300119534134 532 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_688 0527-0193 473 µM 1.36271068799921 0.0967382314176983 no 364 0.0864868540338112 471 4007154 SGTC_2533 agelasine 13.65 µM 1.36029603891483 0.0971340614038726 no 365 0.0868681306805986 543 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2628 lathosterol 100 µM 1.35821186358947 0.0974766719709002 no 366 0.0871982336046134 510 6710616 SGTC_2237 6667747 47.222 µM 1.35732787392071 0.097622255449671 no 367 0.0873385272035077 473 729940 YDL015C TSC13 SGTC_3277 9138724 49.47 µM 1.35688035801321 0.0976960172090588 no 368 0.0874096144372843 384 15943418 SGTC_2839 9003951 25.97 µM 1.35388169579147 0.0981913258572245 no 369 0.0878870620577179 476 2990634 SGTC_1401 3807-4679 7.6 µM 1.35377861184129 0.0982083855531478 no 370 0.0879035096176032 470 3291456 SGTC_785 1270-0111 65.3 µM 1.35368768252757 0.0982234355411832 no 371 0.0879180197498724 505 6741994 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.35342715804846 0.0982665650965171 no 372 0.0879596030834 498 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2892 9047358 58.44 µM 1.35100198938373 0.0986687149500784 no 373 0.0883473977138606 455 6466771 SGTC_3007 9078383 71.4286 µM 1.34494818071022 0.0996778323458886 no 374 0.0893209847101218 500 6496995 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.34270833835963 0.100053099344785 no 375 0.0896832168232591 508 97141 SGTC_1078 idebenone 36.1 µM 1.33816742816576 0.100817054746759 no 376 0.0904209321736215 584 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3132 9126706 49.47 µM 1.33777641284555 0.100883036896944 no 377 0.090484666531234 475 850858 SGTC_2798 7813637 45.45 µM 1.33403298387476 0.101516318561673 no 378 0.0910965235041816 523 956368 SGTC_1336 1486-0901 104 µM 1.33172740139291 0.101907795470795 no 379 0.0914748908212139 510 5006114 SGTC_2084 5306078 60.6385 µM 1.3296301839634 0.102264846225548 no 380 0.0918200740227057 524 679340 SGTC_3056 9094900 49.47 µM 1.32898768288308 0.102374413740951 no 381 0.0919260167731369 507 25236784 SGTC_2453 5731132 22.18 µM 1.3283964650522 0.102475311176133 no 382 0.0920235833216373 560 1362040 SGTC_892 0929-0076 29 µM 1.32712408107615 0.10269270185861 no 383 0.0922338203105841 578 5751038 SGTC_1064 honokiol 6.76 µM 1.32591234798718 0.102900041564144 no 384 0.0924343662099923 546 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2434 5670830 169.91 µM 1.32566820038009 0.102941854461309 no 385 0.0924748124842778 533 1549830 SGTC_1963 st076565 50.3 µM 1.32493719251365 0.103067121204675 no 386 0.0925959918835198 528 4914280 SGTC_200 k038-0079 37.545 µM 1.32306512946986 0.103388425837278 no 387 0.0929068598799519 504 3436683 SGTC_2437 5741531 144.16 µM 1.32107823966342 0.103730233047668 no 388 0.0932376389214116 558 2262990 SGTC_3087 9117406 49.47 µM 1.32002792614331 0.103911250719081 no 389 0.0934128471716442 515 42546093 SGTC_3240 9133527 49.47 µM 1.3172924964587 0.104383767023376 no 390 0.0938702997059256 536 17617455 SGTC_2776 terbinafine 19.92 µM 1.3148502772301 0.104806948279435 no 391 0.0942801131845188 517 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_947 3447-0010 211 µM 1.31095913669277 0.105483758911525 no 392 0.0949357848341177 514 748350 SGTC_1265 0819-1001 68.8 µM 1.30897136488447 0.105830721965181 no 393 0.095272025342147 514 3106768 SGTC_1778 st046819 58.9 µM 1.30853232903598 0.10590746620934 no 394 0.095346408299162 603 671715 SGTC_1291 0993-0025 5.79 µM 1.30328575952311 0.106827689545972 no 395 0.0962386104877957 545 4353356 SGTC_566 0958-0068 16.5 µM 1.30285573882682 0.106903368151371 no 396 0.0963120085930954 484 6815365 SGTC_1740 st038286 13.222 µM 1.2999505808797 0.107415655387133 no 397 0.0968089537427205 550 716786 SGTC_2504 purpurogallin 52.29 µM 1.2996239441648 0.107473364042006 no 398 0.096864944498159 516 5281571 An antioxidant. SGTC_491 tetrandrine 80.3 µM 1.29955814901638 0.107484991125997 no 399 0.0968762257151117 492 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_669 0108-0021 26.2 µM 1.299377984874 0.107516833730614 no 400 0.0969071215436708 655 17201 SGTC_3199 9111318 49.47 µM 1.29931873270594 0.107527307573831 no 401 0.0969172841075352 531 8548020 SGTC_1363 1636-0063 10.4 µM 1.29892328698897 0.107597228258099 no 402 0.0969851285380943 581 6072185 SGTC_206 4546-0025 72.014 µM 1.2986367315125 0.107647915996025 no 403 0.0970343130544371 629 6620745 YIL048W NEO1 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.2977685450919 0.1078015912981 no 404 0.0971834407423995 590 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_545 4218-0007 221 µM 1.29670173673437 0.107990640430785 no 405 0.097366915779428 535 2840508 SGTC_165 k038-0023 64.381 µM 1.29656656070133 0.1080146120089 no 406 0.0973901821567947 588 46368543 SGTC_95 0471-0001 561.058 µM 1.29541761949409 0.108218515347666 no 407 0.0975881015540591 562 4015405 SGTC_2314 7727897 200 µM 1.29539344079303 0.108222809331889 no 408 0.0975922698022405 524 900724 SGTC_1424 4048-1941 275 µM 1.29430850898541 0.108415612578546 no 409 0.0977794392586029 597 X1424 SGTC_492 tmb-8 126 µM 1.29144507647568 0.10892565983077 no 410 0.0982746942965323 377 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2095 5432005 200 µM 1.29044356556205 0.109104459913941 no 411 0.0984483471006227 501 783734 SGTC_680 0417-1641 114 µM 1.28752840880214 0.109626104084647 no 412 0.0989550871443153 512 2835990 SGTC_2584 androsterone 48.74 µM 1.2852151387864 0.110041317868508 no 413 0.0993585574270731 715 2754130 A steroid. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.28481009401433 0.110114136145692 no 414 0.0994293270864104 592 6708561 SGTC_346 4513-0042 7.16 µM 1.28453348939019 0.110163883525433 no 415 0.0994776767758904 579 2827372 SGTC_2117 5521686 200 µM 1.27640900961669 0.111632269633951 no 416 0.100905486507372 556 803312 SGTC_3179 9107801 49.47 µM 1.27434711078173 0.112007146745713 no 417 0.101270213672523 553 4818259 SGTC_2780 5215298 71.43 µM 1.27368516929766 0.112127686024094 no 418 0.10138750725866 602 2834131 SGTC_2468 5987765 72.9 µM 1.27253095500864 0.112338089735524 no 419 0.101592266438172 578 26772094 SGTC_767 0929-0023 86 µM 1.27235594475428 0.112370017271322 no 420 0.101623339767382 661 1204563 SGTC_1440 4100-1550 40 µM 1.27175929154071 0.112478914861721 no 421 0.101729328442178 514 742806 SGTC_834 0312-0008 75.7 µM 1.2714111530824 0.112542489836262 no 422 0.101791208456085 596 6385573 YIL048W NEO1 SGTC_1960 st011366 51.8 µM 1.27103678111076 0.112610884055525 no 423 0.101857781926952 552 3972846 SGTC_2684 capsaicin 100 µM 1.26767959326332 0.113225537491042 no 424 0.102456197590791 535 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1284 0929-0043 16 µM 1.26725928030835 0.113302659090033 no 425 0.102531297672694 587 1239883 SGTC_1005 4092-0690 4.4 µM 1.26505702538678 0.113707354856503 no 426 0.102925443292113 547 1529343 SGTC_590 k048-0076 22.4 µM 1.26420982780289 0.113863313607835 no 427 0.103077362154052 572 6832814 SGTC_3301 9125354 19.7965 µM 1.26414584480255 0.113875098286427 no 428 0.103088842150648 507 41905162 SGTC_234 nsc-17383 10.7 µM 1.26390141654747 0.113920126191095 no 429 0.103132706654707 627 408974 SGTC_3125 9127534 49.47 µM 1.26192200885088 0.114285234668193 no 430 0.103488425800323 467 1639235 SGTC_955 1216-0110 33 µM 1.26070815875606 0.114509545192492 no 431 0.103707006682542 622 3619719 SGTC_93 0109-0045 59.227 µM 1.25771313276215 0.115064343898376 no 432 0.104247760513906 681 88733 SGTC_2274 7947094 46.08 µM 1.25289006786444 0.115961781271602 no 433 0.105122858484826 586 2971028 SGTC_2914 7968218 45.32 µM 1.25022462230154 0.116459872765039 no 434 0.105608752368473 538 2977111 SGTC_445 e6 berbamine 66 µM 1.24697694404242 0.11706881461833 no 435 0.106202975798115 707 6610268 A calcium/calmodulin antagonist. SGTC_2659 sanguinarine 24.21 µM 1.24649887456332 0.117158643111452 no 436 0.106290651065041 586 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_453 enantio-paf c16 10 µM 1.24533162325448 0.117378172903198 no 437 0.106504938024658 751 13871343 A lipid and platelet activating factor SGTC_1119 parthenolide 318.541 nM 1.24463665816241 0.117509016136898 no 438 0.106632669516372 671 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1629 st005085 44.9 µM 1.24142346203755 0.118115316937631 no 439 0.107224678159371 592 24207091 SGTC_43 0570-0105 72.5 µM 1.24114083264686 0.11816875219236 no 440 0.107276863793555 683 1114046 YDL195W SEC31 SGTC_490 phenamil 164 µM 1.23989492414561 0.118404513347728 no 441 0.107507130783377 465 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_687 k029-0044 34.9 µM 1.23775242312689 0.118810712297042 no 442 0.107903937240328 622 5829338 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.23763923748088 0.118832198618924 no 443 0.107924929322739 578 2724278 An inhibitor of dopamine biosynthesis. SGTC_1415 3966-0071 78.1 µM 1.23743213065112 0.118871521345666 no 444 0.107963348199804 576 2893185 SGTC_3119 9125183 49.47 µM 1.2365322271513 0.11904248993202 no 445 0.108130397096537 457 22695334 SGTC_2017 5132927 60.65 µM 1.2361426787116 0.119116552293009 no 446 0.108202766567796 589 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_287 k060-0039 29.6 µM 1.23502179028564 0.119329841106836 no 447 0.108411197276274 576 5861974 SGTC_2474 5321570 43.32 µM 1.23360399544477 0.119600012770193 no 448 0.108675251735411 561 2841384 SGTC_1473 k844-0725 134 µM 1.23226799775252 0.119854991931801 no 449 0.108924495040027 681 54682906 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.23114798196033 0.120069045434177 no 450 0.109133761270647 629 2333 A French combination drug. SGTC_1505 k297-0037 20.6 µM 1.22464667162889 0.121316874144591 no 451 0.110354187522434 616 4089396 SGTC_2072 5231554 129 µM 1.22462959479664 0.121320163748808 no 452 0.110357406020763 599 789545 SGTC_932 2857-0803 154 µM 1.22369120185578 0.121501027980603 no 453 0.110534369949519 647 674898 SGTC_1510 1123-0200 71.5 µM 1.22080534608143 0.122058430263799 no 454 0.111079864590085 687 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_827 3253-0474 693 µM 1.21617567393587 0.122956396996375 no 455 0.111959004163677 646 5402065 SGTC_1280 0880-0253 10.1 µM 1.21307853715115 0.12355969425232 no 456 0.112549897487433 629 6836607 SGTC_1215 3852-0577 11.2 µM 1.21188317809129 0.123793094115264 no 457 0.112778551149832 682 2884876 SGTC_2092 5303694 80.6725 µM 1.21118903358998 0.123928770883059 no 458 0.11291148235796 615 1963699 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.21085961049836 0.123993195982199 no 459 0.112974607202948 644 5106787 A p450 inhibitor. SGTC_2656 pseudo-anisatin 100 µM 1.21020325406631 0.124121629122588 no 460 0.113100454882575 574 6708809 A neurotoxin. SGTC_789 1309-1135 70.6 µM 1.21015169002229 0.124131722905456 no 461 0.11311034584366 614 3092424 SGTC_1315 1237-0019 3.69 µM 1.20983646570096 0.124193441293937 no 462 0.113170825264215 634 825140 SGTC_695 3505-6186 243 µM 1.20947036378162 0.124265148046495 no 463 0.113241095093814 626 1819379 SGTC_75 0159-0059 199.013 µM 1.20758690935268 0.124634509580304 no 464 0.113603098504703 596 5377270 SGTC_35 0133-0054 64.071 µM 1.20003043698301 0.126124111119218 no 465 0.115063759891988 579 99677 SGTC_2233 sulbentine 40.3845 µM 1.19748547846888 0.126628579340097 no 466 0.115558692145717 687 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2525 harmine 47.85 µM 1.18961493188487 0.128197585798077 no 467 0.117098887140006 572 5280953 A monoamine oxidase inhibitor SGTC_987 1497-1013 404 µM 1.18667552446987 0.128787009851115 no 468 0.117677816434703 595 1676435 SGTC_2351 9026858 72.31 µM 1.18325661813088 0.129474947178287 no 469 0.118353730106574 580 1409300 SGTC_1418 3966-3099 2.4 µM 1.18158695798688 0.129811832542889 no 470 0.118684815473656 653 740335 SGTC_3039 9090270 49.47 µM 1.18028189897647 0.130075575033302 no 471 0.118944057468903 592 17173750 SGTC_3196 9111891 49.47 µM 1.17758340518604 0.130622095702483 no 472 0.119481364415818 616 18891510 SGTC_3016 9080866 49.47 µM 1.1760295240069 0.130937519550936 no 473 0.119791539164679 670 17066299 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.17594182498462 0.130955337338088 no 474 0.119809061932691 709 66535 A nucleotide analog. SGTC_458 nppb 133 µM 1.1756351359824 0.131017660435119 no 475 0.119870354366407 611 4549 A chloride channel blocker. SGTC_167 3672-0051 66.205 µM 1.17465987960216 0.131215981087632 no 476 0.120065408287717 592 3237971 SGTC_1248 0469-0687 58.6 µM 1.17231264998125 0.131694145376783 no 477 0.120535777325565 654 4017482 SGTC_1855 st056195 39.6 µM 1.17172173182375 0.131814713087029 no 478 0.120654397532481 631 4028379 SGTC_727 3032-0951 202 µM 1.17133463063409 0.131893736367849 no 479 0.120732148302925 597 3652836 SGTC_2168 5727979 200 µM 1.17058241270584 0.132047388433344 no 480 0.120883335022438 582 695210 SGTC_3045 9092950 49.47 µM 1.16688826548213 0.132803766120473 no 481 0.121627747691095 693 44120432 SGTC_2733 amorolfine 100 µM 1.16647249613248 0.132889081435377 no 482 0.121711731209696 537 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2269 7935389 174.42 µM 1.16645365941685 0.132892947597636 no 483 0.121715537105285 635 97605 SGTC_1862 st057513 3.81 µM 1.16509047474168 0.133172941541834 no 484 0.121991186059904 630 5393163 SGTC_3291 9121177 71.43 µM 1.16318783624577 0.133564415966264 no 485 0.122376650296638 543 17015612 SGTC_2423 st077119 87.2 µM 1.16238952684208 0.133728906323001 no 486 0.122538637762888 652 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_575 k072-0246 11.9 µM 1.16217838030273 0.133772436003511 no 487 0.122581507316364 670 6796779 SGTC_1868 st057644 42.7 µM 1.16043106534495 0.13413303386837 no 488 0.122936672419402 687 688665 SGTC_478 N-arachidonylglycine 10 µM 1.15823774745272 0.134586618896337 no 489 0.123383513987695 522 5283389 SGTC_1024 4507-0395 26 µM 1.15668649223574 0.134908058275529 no 490 0.123700235197002 639 4201836 SGTC_729 4092-0585 94.1 µM 1.15294135270955 0.135686266942891 no 491 0.124467228611981 607 2169061 SGTC_3093 9117344 49.47 µM 1.15143181609169 0.136000803819941 no 492 0.124777315500074 618 24824913 SGTC_49 0717-0965 32.132 µM 1.15026438393002 0.136244399621051 no 493 0.125017497673846 670 5889349 YGL099W LSG1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.15010781195173 0.136277092542446 no 494 0.125049734622442 643 6710655 SGTC_389 tpck 16.7 µM 1.15006596587328 0.136285831097613 no 495 0.125058351386617 657 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2319 6033012 152.6 µM 1.14867675496481 0.136576152309816 no 496 0.125344647147006 597 847246 SGTC_2639 lactacystin 53 µM 1.14603560133301 0.137129273743122 no 497 0.125890210830297 695 3870 A proteasome inhibitor. SGTC_2450 5739737 12.93 µM 1.14577223966039 0.137184511833708 no 498 0.125944702172955 633 2262825 SGTC_336 4111-0029 111 µM 1.14370496574202 0.137618634580842 no 499 0.126373006658936 612 3131175 SGTC_3251 9135047 49.47 µM 1.13958984709814 0.138485588515122 no 500 0.1272286085824 616 17682963 SGTC_2057 5236571 38.335 µM 1.13784716502438 0.138853847993528 no 501 0.127592153265287 699 54684039 YBR257W POP4 SGTC_3177 9107506 49.47 µM 1.13631920271763 0.139177281596541 no 502 0.127911498485556 628 8897194 SGTC_1987 st072290 61.9 µM 1.13588226877029 0.139269864409858 no 503 0.128002920020398 694 54697379 SGTC_2806 7952793 58.44 µM 1.13425125981654 0.139615832307651 no 504 0.128344583854141 675 2972490 SGTC_1281 0884-0031 11.8 µM 1.13421694688262 0.139623117002316 no 505 0.128351778523116 703 1548255 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.13411246687239 0.139645299879145 no 506 0.128373687411992 759 551469 SGTC_1865 st057639 52.2 µM 1.12989728800322 0.140542252740842 no 507 0.129259753429554 677 688818 SGTC_2741 miltefosine 3.04 µM 1.1297896956036 0.140565198524979 no 508 0.129282425602673 575 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1481 3346-2004 36 µM 1.12927791804294 0.140674378014256 no 509 0.129390306545543 697 2770522 SGTC_3076 9116187 49.47 µM 1.12610896474843 0.141351704422165 no 510 0.130059699961464 623 27241210 SGTC_1527 coumarin 137 µM 1.12568139866205 0.14144326059063 no 511 0.130150200006938 618 323 A hepatotoxic, DNA x-linker. SGTC_2761 levamisole 97.89 µM 1.12319629270938 0.141976200230433 no 512 0.130677068379806 660 26879 An alkaline phosphatase inhibitor. SGTC_205 1486-1330 71.903 µM 1.12255455591877 0.142114043493314 no 513 0.130813362486247 631 4118834 SGTC_2863 9028737 58.44 µM 1.11689117263731 0.143334448949812 no 514 0.13202042969868 660 6460917 SGTC_547 1120-0019 610 nM 1.11327042180071 0.144118384470036 no 515 0.132796152858971 691 3676939 SGTC_1190 1486-1332 13 µM 1.11294538800882 0.144188899285197 no 516 0.132865942529758 686 4150046 SGTC_2862 9027634 71.43 µM 1.11186116588718 0.144424285236753 no 517 0.133098924023267 648 5012562 SGTC_1275 0867-0008 21.1 µM 1.1116666892783 0.144466533721134 no 518 0.133140743569557 703 3422836 SGTC_512 prima-1 270 µM 1.1098699760039 0.144857249142917 no 519 0.133527529995588 720 322968 A re-activator of the apoptotic function of mutant p53. SGTC_538 2922-0838 53.3 µM 1.10845905152383 0.145164568780964 no 520 0.133831807142857 768 777039 SGTC_681 1642-0006 26.6 µM 1.09892558800914 0.147252587525897 no 521 0.135900262261101 694 4446530 SGTC_1372 2752-0194 270 µM 1.09834980917484 0.147379335999804 no 522 0.136025884926155 650 823334 SGTC_1806 st050005 60.3 µM 1.09677430572199 0.147726531441749 no 523 0.136370032447226 682 5194765 SGTC_313 3474-0040 5.03 µM 1.09498424419821 0.148121673487317 no 524 0.136761769593655 735 1043375 YIL048W NEO1 SGTC_2706 st078239 82.5 µM 1.09246385199038 0.148679228254212 no 525 0.137314635328809 713 15434492 SGTC_1662 st014054 52 µM 1.0915793777576 0.1488752215181 no 526 0.137509012266284 684 2838777 SGTC_1457 k015-0032 57.3 µM 1.08738977958684 0.149805951871898 no 527 0.138432293041101 721 4302660 SGTC_1931 st074438 57.1 µM 1.08688543267539 0.149918255045314 no 528 0.138543722499327 683 2787313 SGTC_2627 acetyl isogambogic acid 100 µM 1.08610443568888 0.150092270785032 no 529 0.138716395069245 662 6857789 A caspase activator and apoptosis inducer. SGTC_2928 9011484 9.79 µM 1.08563270591187 0.150197443188906 no 530 0.138820761962132 664 2994751 SGTC_2744 captopril 92.04 µM 1.08483888959515 0.150374535809896 no 531 0.138996508916017 652 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.08380900789399 0.150604499555699 no 532 0.13922474521311 737 3256 An antibiotic and ribosome inhibitor. SGTC_2778 tioconazole 65.09 nM 1.0811925874475 0.151189776646427 no 533 0.139805727313513 718 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3075 9116269 49.47 µM 1.08054681220305 0.151334465088026 no 534 0.139949376387654 725 17015205 YNL244C SUI1 SGTC_2315 7733312 200 µM 1.08017065028734 0.151418788050868 no 535 0.140033097706564 665 726316 SGTC_218 alverine citrate 93.75 µM 1.07744014935235 0.152031811711908 no 536 0.140641837760866 696 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1324 1418-0026 34.4 µM 1.07504782921754 0.152570263486786 no 537 0.141176657569594 746 1372513 SGTC_951 1171-0579 82.7 µM 1.07267800723476 0.153104897508509 no 538 0.141707805641735 796 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_264 promethazine 12.5 mM 1.07096789203698 0.153491471495693 no 539 0.142091933430933 861 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2234 tolnaftate 200 µM 1.07063619741987 0.153566526326491 no 540 0.142166520538809 682 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_577 r071-0003 38.6 µM 1.06928829025824 0.15387177659914 no 541 0.142469892696198 863 4568517 YMR134W ERG29 SGTC_954 1189-0853 2.85 µM 1.06835560736963 0.154083229098038 no 542 0.142680066862915 758 2828194 SGTC_2667 digitoxin 100 µM 1.06767147825425 0.154238453074682 no 543 0.142834364226158 648 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1307 1187-1599 12.2 µM 1.06741322817599 0.154297075038829 no 544 0.142892638838942 740 1538471 SGTC_738 1315-0003 72.4 µM 1.06698859256878 0.154393498026829 no 545 0.142988493584895 760 6251474 SGTC_3167 9103034 49.47 µM 1.06303312363659 0.155293589086123 no 546 0.143883465135264 686 5127859 SGTC_2173 5763948 167 µM 1.06023855674316 0.15593159343016 no 547 0.144518042110085 766 2867177 SGTC_3283 9109332 35.8195 µM 1.05769873595593 0.156512935451069 no 548 0.145096405864583 649 17027281 SGTC_2964 9083345 53.42 µM 1.05695695924821 0.156682990344563 no 549 0.145265615542856 673 17741579 SGTC_1887 st057648 70.8 µM 1.05689119631221 0.156698072593469 no 550 0.145280623396054 754 688672 SGTC_2569 tetrandrine 100 µM 1.05609326825231 0.156881147699014 no 551 0.145462802810348 661 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_125 0133-0007 11.75 µM 1.05384687133017 0.157397312278701 no 552 0.145976515125269 816 26541 SGTC_1885 st057546 99.9 µM 1.05264006883534 0.157675065034215 no 553 0.146252992819096 780 702008 SGTC_900 1112-0045 141 µM 1.04990116178416 0.158306634689193 no 554 0.14688177869554 612 56211 YIL048W NEO1 SGTC_1020 4335-0961 93.3 µM 1.04946179936963 0.158408102359095 no 555 0.146982814048046 710 669075 SGTC_1244 0416-0015 52.5 µM 1.04774283883507 0.158805494137434 no 556 0.147378552340045 746 96201 SGTC_2860 9025725 38.96 µM 1.04689747390141 0.159001166322892 no 557 0.147573433536314 709 40546248 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.04551640568108 0.15932117464929 no 558 0.147892181129385 726 689007 SGTC_1437 4092-1038 11.6 µM 1.04537336633253 0.159354342486775 no 559 0.147925220626204 796 3977136 SGTC_1732 st034308 51.822 µM 1.04032220089696 0.160528500859188 no 560 0.149095116567669 721 830119 SGTC_323 4013-0906 34.3 µM 1.03998157681806 0.160607882833855 no 561 0.149174230021964 771 2910086 SGTC_1768 st044301 37.178 µM 1.03440099331685 0.161912080527354 no 562 0.150474370118508 782 3931349 SGTC_2739 tacrine 100.86 µM 1.03380214422505 0.162052441987369 no 563 0.150614334514145 714 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2061 5245884 80.95 µM 1.03324969610627 0.162181997994333 no 564 0.150743530830553 769 573863 SGTC_2475 5812728 15.03 µM 1.03231066429857 0.162402367421539 no 565 0.150963303429709 795 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1690 st023502 41.2 µM 1.03118373934236 0.162667088258879 no 566 0.151227332246205 748 24207482 SGTC_2086 5274770 176.623 µM 1.03029471102142 0.162876123830075 no 567 0.151435840553957 768 689278 SGTC_2175 5807670 165.306 µM 1.02983458191492 0.162984381693595 no 568 0.151543831997311 772 241186 SGTC_630 4356-0227 183 µM 1.02957490398532 0.163045498620454 no 569 0.15160480051753 737 779312 SGTC_2869 9037858 32.47 µM 1.02739926583027 0.163558134686931 no 570 0.152116248529265 717 27187042 SGTC_881 0833-0569 170 µM 1.02734514212765 0.163570900945477 no 571 0.152128986493703 765 5418700 SGTC_2887 9044784 58.44 µM 1.02229834886515 0.164764140260409 no 572 0.153319857240062 866 6465546 SGTC_2480 5767542 37.17 µM 1.02215276858257 0.164798644023407 no 573 0.153354300613473 797 2867358 SGTC_3321 9137793 26.8275 µM 1.01862180545655 0.165636945507851 no 574 0.154191274049935 783 4904192 SGTC_560 2332-1943 155 µM 1.01629634311051 0.166190547181134 no 575 0.154744144743823 788 21177716 SGTC_460 trequinsin 123 µM 1.01346741309056 0.166865614245252 no 576 0.155418476829214 855 5537 A vasodilator. SGTC_1186 1319-0216 26 µM 1.01168110874089 0.167292789554965 no 577 0.155845275458876 841 4565136 SGTC_675 1309-0189 238 µM 1.0111942883338 0.167409329484915 no 578 0.155961724485685 756 4246530 SGTC_1496 4469-0713 57.4 µM 1.00836321794562 0.168088095766801 no 579 0.156640062056694 788 746691 SGTC_402 epigallocatechin gallate 10 µM 1.00817236804351 0.168133916815126 no 580 0.156685860347048 798 65064 An antioxidant. SGTC_117 lucigenin 22.078 µM 1.00801914105334 0.168170710815214 no 581 0.156722636637616 825 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2047 4141938 200 µM 1.00647022035908 0.168542939960617 no 582 0.157094714889218 737 3807862 SGTC_1770 st043884 66.3 µM 1.00616746489775 0.168615758529321 no 583 0.157167509948194 800 670149 SGTC_3337 9144342 33.5465 µM 1.00384221547178 0.169175700151805 no 584 0.157727336326498 815 17682949 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.00145230178946 0.169752456227423 no 585 0.158304094595117 828 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2539 epi(13)torulosol 80 µM 1.00144378733017 0.169754513267211 no 586 0.158306151861669 747 6708597 SGTC_450 aminopyrene 156 nM 0.998916820278662 0.17036571896803 no 587 0.158917493662887 808 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2488 5268135 45.7 µM 0.998058510685473 0.170573641390704 no 588 0.159125493547149 867 1270356 YLR208W SEC13 SGTC_578 3460-0051 92 µM 0.997927869235527 0.170605303054428 no 589 0.159157168391447 923 2876744 SGTC_2123 5259487 200 µM 0.997236546295368 0.170772911547924 no 590 0.159324852751423 844 2173474 SGTC_1236 0330-0013 258 µM 0.994893407524551 0.171341779800062 no 591 0.159894054768819 785 4617066 SGTC_266 formosanin C 406 nM 0.992690992868287 0.171877586102619 no 592 0.160430282854848 802 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1264 0783-0040 158 µM 0.991851817745624 0.172082022913224 no 593 0.160634907971952 771 2855798 SGTC_2715 st079500 56.4 µM 0.988838581636622 0.172817375183462 no 594 0.161371062130788 759 28246688 SGTC_928 2764-0428 58.7 µM 0.988358773456015 0.17293465248281 no 595 0.16148848529455 848 662578 SGTC_2212 7123476 200 µM 0.988295520070476 0.172950116998348 no 596 0.161503969412415 730 1085715 SGTC_628 1636-0253 16 µM 0.988068762006874 0.173005563226072 no 597 0.16155948662697 823 4456143 SGTC_751 0833-0568 350 µM 0.984579618207967 0.173860145999003 no 598 0.162415302630844 804 6954252 SGTC_1326 1431-2094 10.8 µM 0.984086685798927 0.173981094132601 no 599 0.162536446356098 805 616278 SGTC_2045 5106652 78.05 µM 0.98098598382707 0.174743122639902 no 600 0.163299826733439 833 673349 SGTC_2927 9011802 47.9 µM 0.979941290658025 0.175000342901408 no 601 0.163557549767319 774 43912568 SGTC_1800 st050079 29.0735 µM 0.979784007830837 0.175039089259285 no 602 0.163596373886925 917 3645560 SGTC_2127 5253358 187.912 µM 0.973517000902617 0.176587383160597 no 603 0.165148207432078 733 20612 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.972768126200137 0.176772973799093 no 604 0.165334278730325 903 368090 SGTC_2000 st075254 36.4 µM 0.971992484653184 0.176965327901521 no 605 0.16552714368469 809 17234175 SGTC_175 3793-3120 23.7 µM 0.970744783314305 0.177275027173629 no 606 0.16583769251736 776 5322297 SGTC_2790 5423970 71.43 µM 0.968706254850391 0.17778175820894 no 607 0.166345885443129 871 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_636 0kpi-0074 126 µM 0.968048437856596 0.177945471111957 no 608 0.166510089662121 800 616434 SGTC_3184 9108758 49.47 µM 0.966623461744521 0.178300435130492 no 609 0.166866150771107 832 902885 SGTC_580 1123-0028 41 µM 0.965399936329071 0.178605573210194 no 610 0.167172266679766 940 1677248 YPR107C YTH1 SGTC_3246 9135460 32.98 µM 0.962862020981321 0.179239558103617 no 611 0.167808385563311 763 41446951 SGTC_2200 6600604 21.907 µM 0.959953801646151 0.179967784756879 no 612 0.168539233278951 849 2904777 SGTC_845 0330-0138 4.51 µM 0.955830368111568 0.181003484250589 no 613 0.169578971513292 858 9039800 SGTC_1120 ficusin 1.78878 µM 0.955353099064143 0.18112360254159 no 614 0.169699581737425 857 6199 A DNA cross-linker. SGTC_1318 1280-3875 124 µM 0.952938335479689 0.181732111475877 no 615 0.170310657584107 857 373245 SGTC_1219 1469-0211 33.1 µM 0.94922700176267 0.182669840117322 no 616 0.171252585617702 851 6822282 SGTC_2363 9053361 176 µM 0.949049595741808 0.18271474015664 no 617 0.171297694118674 851 6469797 YMR079W SEC14 SGTC_1335 1486-0900 202 µM 0.947149274741018 0.183196128265728 no 618 0.171781359487414 872 X1335 SGTC_1744 st037937 38.9 µM 0.946841395555515 0.183274194420578 no 619 0.171859802219827 834 1016152 SGTC_141 0443-0274 32.331 µM 0.944049858978796 0.183982965703522 no 620 0.17257208513327 964 1627241 SGTC_1892 st058411 7.36 µM 0.943191568666449 0.184201228250375 no 621 0.172791462600171 923 3934738 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.942777397274061 0.184306609328018 no 622 0.172897387619382 917 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2996 9066192 71.4286 µM 0.941785453205284 0.184559150394124 no 623 0.173151247139454 836 6472854 SGTC_415 dibenzyl ketone 100 µM 0.940221350437362 0.184957795461379 no 624 0.17355201621154 874 7593 SGTC_2070 5230947 200 µM 0.93955708319026 0.185127259931724 no 625 0.173722399432975 926 2835538 SGTC_2975 9084847 53.72 µM 0.939464510983517 0.18515088413518 no 626 0.173746152464162 866 27211724 SGTC_800 3448-7362 155 µM 0.939462652382363 0.185151358464877 no 627 0.173746629382355 1050 15991913 SGTC_1923 st058458 19.1 µM 0.939083292760479 0.185248189835767 no 628 0.173843990724423 922 3534982 SGTC_289 k017-0060 526 µM 0.937631029663907 0.185619169878549 no 629 0.17421702964177 855 5512909 SGTC_1102 cgs 12066b 26.1 µM 0.937289155622138 0.185706568456615 no 630 0.174304919825573 835 6438352 A 5-HT1B full agonist. SGTC_1550 gossypolone 36.6 µM 0.935420889613526 0.186184633183017 no 631 0.174785717764392 918 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2620 irigenin 100 µM 0.93489179167418 0.18632016085939 no 632 0.174922033847537 894 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2149 5554786 194.827 µM 0.934626665596427 0.186388095504625 no 633 0.174990365940369 896 745063 YPR165W RHO1 SGTC_917 harmaline 728.087 nM 0.934186692518525 0.186500865968595 no 634 0.175103799476799 855 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_660 4031-1742 102 µM 0.93342477031126 0.186696255845147 no 635 0.175300348002698 870 6738706 SGTC_334 1502-1024 68.5 µM 0.932202586340557 0.187009941345242 no 636 0.175615919558246 896 3296216 SGTC_3067 9117431 49.47 µM 0.931282511329568 0.187246302610447 no 637 0.175853723027686 830 17150885 SGTC_1443 4112-3303 14 µM 0.928507074346209 0.187960412589917 no 638 0.176572299940216 875 704433 SGTC_1591 genipin 88.4 µM 0.9282363636345 0.188030155370405 no 639 0.176642487789457 855 442424 A DNA cross-linking agent. SGTC_94 0334-0113 514.748 µM 0.92740892254728 0.188243426748738 no 640 0.176857129879893 890 6795178 SGTC_1030 k029-0042 36.7 µM 0.926849237435381 0.188387769117371 no 641 0.177002408239694 895 6080581 SGTC_3165 9101544 49.47 µM 0.92422217340461 0.189066198809797 no 642 0.177685326666009 888 5002184 SGTC_1666 st014829 29 µM 0.923898474589631 0.18914989685372 no 643 0.177769588685617 911 3858230 SGTC_854 0422-0053 192 µM 0.923683046700657 0.18920561218163 no 644 0.177825680675158 885 3596728 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.923464963930393 0.189262024423115 no 645 0.177882475298723 975 6708784 An antioxidant flavonoid SGTC_2674 ligustilide 100 µM 0.922200955115971 0.189589193952729 no 646 0.178211882496752 855 5319022 A signalling regulator. SGTC_2268 7933382 153.85 µM 0.92201363065039 0.189637709638782 no 647 0.178260732906196 1001 935025 YOR257W CDC31 SGTC_2793 7325131 81.82 µM 0.919473139828467 0.190296432358015 no 648 0.178924074321896 852 4176441 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.918895562064546 0.190446388104541 no 649 0.179075100716252 891 4213774 SGTC_2560 caryophyllene 100 µM 0.918569218101187 0.190531148427388 no 650 0.179160469353779 1007 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1609 st001574 46.4 µM 0.918044503959521 0.19066747938016 no 651 0.179297783500383 901 3960012 SGTC_1994 st072947 40.9 µM 0.916628907919241 0.191035577350567 no 652 0.179668565426216 888 5286565 YDL195W SEC31 SGTC_1478 0453-0656 35.7 µM 0.916147959135214 0.191160737767769 no 653 0.179794648167844 911 5258496 SGTC_228 caffeine 993.056 µM 0.915743405787751 0.191266056227853 no 654 0.179900746553675 861 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_516 3992-2719 87.3 µM 0.913970416779495 0.19172804259732 no 655 0.180366195291541 878 5350887 YDR037W KRS1 SGTC_3295 9122362 53.5725 µM 0.913118866761535 0.191950173029984 no 656 0.180590014315135 832 4730473 SGTC_1817 st052116 64.4 µM 0.91256125751844 0.192095713072317 no 657 0.180736669098286 880 4361398 SGTC_2110 5483698 200 µM 0.912387343362398 0.192141119734049 no 658 0.18078242490075 884 2848765 YHR062C RPP1 SGTC_2283 7944793 200 µM 0.912014791677535 0.192238410097105 no 659 0.180880465517706 904 2970533 SGTC_790 1575-0012 79.1 µM 0.910129803326968 0.192731128954019 no 660 0.181377029328164 934 378741 YLR208W SEC13 SGTC_645 0845-0943 5.41 µM 0.909518319394394 0.192891130921385 no 661 0.181538296143622 860 1885106 SGTC_1354 1498-1681 81 µM 0.908416068251878 0.193179752769846 no 662 0.181829219728872 949 5754243 SGTC_1616 st002734 56.1 µM 0.908368663841072 0.193192171412055 no 663 0.181841737989152 924 4026101 SGTC_1063 disulfiram 1.84 µM 0.905867347814953 0.193848137971549 no 664 0.182503034398625 892 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_821 1114-0266 29.2 µM 0.903490256569781 0.194472783229623 no 665 0.183132878549865 881 3123235 SGTC_185 k048-0037 25.491 µM 0.902295869016618 0.194787102911265 no 666 0.183449859709749 941 6827589 SGTC_1093 fluphenazine 7.97 µM 0.901883793027945 0.194895618091541 no 667 0.183559300776887 929 6602611 An atypical antipsychotic. SGTC_2775 cyproheptadine 69.59 µM 0.900919505427102 0.19514969508814 no 668 0.183815559759556 943 2913 A selective serotonin reuptake inhibitor. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.899747710437501 0.195458718343287 no 669 0.184127263499258 881 5379071 SGTC_711 k292-0785 179 µM 0.899746537334058 0.195459027860449 no 670 0.18412757571582 958 4146315 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.897667316669542 0.19600808703019 no 671 0.184681469411784 947 165521 SGTC_2812 7970281 58.44 µM 0.89684737839418 0.196224864861854 no 672 0.184900181270737 924 2233435 SGTC_2016 5121758 140 µM 0.896053231439914 0.196434962424341 no 673 0.18511216688436 985 2795203 SGTC_493 zm226600 134 µM 0.893408573230914 0.197135609063007 no 674 0.185819206592976 918 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2439 5492030 7.2 µM 0.893395565175699 0.197139059007017 no 675 0.185822688383346 913 5722370 SGTC_1638 st008370 60.6 µM 0.892931271866318 0.197262220930294 no 676 0.185946989564845 891 24207134 SGTC_791 1348-1292 225 µM 0.891843554813627 0.197550939109392 no 677 0.186238396339094 979 5437054 SGTC_1897 st060201 15 µM 0.888599243569456 0.198413609008062 no 678 0.187109248877644 859 611878 SGTC_579 4491-1009 110 µM 0.884709091901124 0.199451000782207 no 679 0.188156775378387 1128 1271041 SGTC_2442 5158906 48.48 µM 0.883494063665304 0.199775681901948 no 680 0.188484694254315 938 1893835 SGTC_3033 9090887 49.47 µM 0.883152317246446 0.199867060995908 no 681 0.188576990229341 951 19325384 SGTC_2664 lyso-paf C-16 73.48 µM 0.880544261152218 0.200565253029471 no 682 0.189282269344534 982 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3155 9099265 49.47 µM 0.880134550994718 0.200675067815122 no 683 0.189393211917532 855 25236499 SGTC_2384 9036245 200 µM 0.873556124113058 0.202443224371175 no 684 0.191180014611201 964 6462766 SGTC_629 3448-6466 76.7 µM 0.87311165158067 0.202563025183139 no 685 0.19130111182994 962 573744 SGTC_1384 3089-0840 101 µM 0.87233877989684 0.20277144187766 no 686 0.191511793821367 904 1069836 SGTC_2841 9004761 38.96 µM 0.872107152417595 0.202833928721721 no 687 0.191574962298878 898 2991039 SGTC_120 rhodamine 6G 52.259 µM 0.871941930710962 0.202878508108659 no 688 0.191620028669889 1072 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2205 7238770 200 µM 0.871423268476249 0.203018489267165 no 689 0.19176154272733 960 279867 SGTC_1471 k673-0312 37 µM 0.871207980526632 0.203076610020402 no 690 0.191820301616123 960 24099884 SGTC_2647 atorvastatin 60.16 µM 0.871172239974142 0.203086259770065 no 691 0.191830057409791 924 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2192 5915882 198.485 µM 0.869267809357934 0.203600841258381 no 692 0.192350332836556 926 2876149 SGTC_1836 st055642 81 µM 0.867060878082252 0.204198130712179 no 693 0.192954327292797 988 8571 SGTC_686 1319-0111 510 µM 0.866950256736345 0.204228096991035 no 694 0.192984632671483 992 4562600 SGTC_573 3702-0553 84.7 µM 0.866027374678036 0.204478199074607 no 695 0.193237574989221 914 1222756 SGTC_114 0364-0001 490.298 µM 0.86567909583477 0.204572630391637 no 696 0.193333083368589 931 4003655 SGTC_251 melphalan 456.522 µM 0.864047989365564 0.205015229102513 no 697 0.193780764332309 1051 460612 A DNA alkylator. SGTC_2366 9070441 60.58 µM 0.863706037800094 0.205108089356831 no 698 0.193874697995637 1005 6837235 SGTC_2305 7443522 69.23 µM 0.862748090235169 0.20536836234527 no 699 0.194137992716813 972 5415886 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.858747565328972 0.206457417546054 no 700 0.195239900980037 983 688751 SGTC_795 0685-0265 78 µM 0.853562931015384 0.207873899389323 no 701 0.196673602498949 1019 302754 SGTC_902 1120-0002 2.07 µM 0.853190364638736 0.207975907915893 no 702 0.196776872902766 968 3280475 SGTC_1545 lovastatin 49.4 µM 0.852459579280933 0.208176082473128 no 703 0.196979532159971 1007 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3047 9092122 49.47 µM 0.85236692050616 0.208201471409019 no 704 0.197005237042344 942 17173831 SGTC_1818 st052136 56.3 µM 0.852125199861573 0.208267712591277 no 705 0.19707230339656 919 674169 SGTC_3212 9128307 49.47 µM 0.851099156766118 0.20854902805669 no 706 0.197357136905905 837 27243542 SGTC_890 0929-0006 47.2 µM 0.850548952171173 0.208699972689782 no 707 0.19750997832041 935 1378169 SGTC_2779 methotrexate 400 µM 0.850028127382255 0.208842916495055 no 708 0.197654724229009 1055 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_679 0422-0091 41.4 µM 0.849722100274375 0.208926934555926 no 709 0.197739804170022 1030 627384 YHR062C RPP1 SGTC_1399 3562-5772 25 µM 0.848698643900383 0.209208063485861 no 710 0.19802450050088 894 23847490 SGTC_1145 3546-0597 10.2 µM 0.848645684000774 0.209222616875428 no 711 0.19803923916513 972 875334 SGTC_674 0498-0004 451 µM 0.848472395753255 0.209270240680981 no 712 0.198087469666189 918 4231473 SGTC_1958 st076513 41.9 µM 0.847901603587569 0.20942715330242 no 713 0.198246385709002 992 732122 YGL099W LSG1 SGTC_414 piperonyl butoxide 100 µM 0.844547568030392 0.210350586159935 no 714 0.199181746991134 958 5794 A potent inhibitor of cytochrome P450. SGTC_2921 7974240 10.71 µM 0.844064116089181 0.210483886963347 no 715 0.199316789174469 957 2979074 YDR527W RBA50 SGTC_1485 3909-9022 254 µM 0.843471913480605 0.210647240819549 no 716 0.199482283689382 1048 714516 SGTC_2743 auranofin 4.32 µM 0.843380227912321 0.210672538121055 no 717 0.199507913154878 961 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_756 0508-1999 28.3 µM 0.843248511736777 0.210708883533616 no 718 0.199544736106118 931 6753853 SGTC_847 0342-0274 5.54 µM 0.842410583980264 0.210940185216711 no 719 0.199779085355715 1017 18097 SGTC_2899 9053889 58.44 µM 0.842299619073847 0.210970827142019 no 720 0.199810132114036 980 6470052 SGTC_371 0195-0006 7.36 µM 0.841702555503695 0.211135745475808 no 721 0.199977233735209 879 3928593 SGTC_1849 st056239 19.2 µM 0.84156751487256 0.21117305629234 no 722 0.200015039530478 940 5393181 SGTC_2514 salinomycin 42.74 µM 0.840010359076453 0.211603567011006 no 723 0.200451289170115 1064 23682228 A polyether potassium ionophore. SGTC_2418 pentamidine 31.67 µM 0.8398142990426 0.211657808607927 no 724 0.200506257434833 975 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2429 5902844 64.44 µM 0.839099945998194 0.21185550899958 no 725 0.200706613203643 1021 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2132 5317594 122.667 µM 0.838820928435142 0.211932757685358 no 726 0.200784902343018 929 794577 SGTC_2019 4016004 108 µM 0.838088576452145 0.212135594709921 no 727 0.200990479109497 949 45595336 SGTC_1610 st001799 48.1 µM 0.837687940496466 0.21224660549343 no 728 0.201102994078627 903 621897 SGTC_1006 4099-6547 255 µM 0.837276942878966 0.212360522629138 no 729 0.20121845827136 975 3146833 SGTC_91 0417-1751 58.384 µM 0.837036497858348 0.212427183879203 no 730 0.201286026456467 1135 6795624 SGTC_1841 st054148 70 µM 0.836314334344223 0.212627470798656 no 731 0.201489045578423 910 675442 SGTC_1197 1601-0112 267 µM 0.835030440206572 0.212983821899632 no 732 0.201850284766648 982 7350313 SGTC_2167 5876490 200 µM 0.834245897540193 0.213201746980345 no 733 0.20207121610785 1010 686534 SGTC_1334 1486-0610 236 µM 0.832611842710211 0.213656061200426 no 734 0.202531838878261 986 3742339 SGTC_338 4055-0136 114 µM 0.831366709189384 0.21400262240827 no 735 0.202883249856978 1015 2900563 SGTC_147 4466-0538 29.23 µM 0.83127091381916 0.214029298928257 no 736 0.202910301029202 1112 6742687 YHR072W ERG7 SGTC_2774 tamoxifen 10.92 µM 0.82909860781271 0.21463474907635 no 737 0.203524305736802 1019 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3220 9131269 49.47 µM 0.828782799423639 0.21472285181565 no 738 0.203613661504066 1010 17722206 SGTC_1947 st076332 61.6 µM 0.827805502040735 0.214995626746362 no 739 0.203890329120135 1015 24208416 SGTC_1161 k007-0610 110 µM 0.827800188218363 0.214997110445083 no 740 0.203891834046714 1074 5843850 SGTC_3190 9110366 49.47 µM 0.827632303248713 0.215043989502206 no 741 0.203939384124036 929 17123768 SGTC_2552 juarezic acid 87.02 µM 0.827568460112524 0.2150618181829 no 742 0.20395746815621 1141 1549512 SGTC_1664 st014217 9.02 µM 0.826416847525312 0.215383562078554 no 743 0.204283834829331 1106 3982782 SGTC_2151 5563267 85.4165 µM 0.825835721496244 0.215546026243201 no 744 0.204448643757893 1008 5310824 SGTC_2707 st078556 66.6 µM 0.825212769656605 0.21572026246276 no 745 0.20462540245928 991 17250899 SGTC_646 4092-0839 27.3 µM 0.822033446600116 0.216610772480561 no 746 0.205528930727499 1039 877796 SGTC_350 k064-0020 19.8 µM 0.821843961840593 0.216663913127403 no 747 0.205582854878397 1038 2790705 SGTC_1950 st077106 7.18 µM 0.821714881732211 0.216700117720211 no 748 0.205619593698495 971 13831864 SGTC_2214 7179297 48.276 µM 0.821535149697084 0.216750535072756 no 749 0.205670755576325 1020 769744 SGTC_2618 avocadyne 43.43 µM 0.820359048725708 0.21708061524006 no 750 0.206005726710992 985 3015189 SGTC_471 1-acyl-paf 4 µM 0.817842364024198 0.217787913601299 no 751 0.206723602182555 1001 16759367 SGTC_203 k066-0004 30.888 µM 0.817108906336527 0.217994297148388 no 752 0.206933096824313 1129 6795412 SGTC_1266 0828-0227 32.9 µM 0.816831813988104 0.218072295947532 no 753 0.207012274312589 980 3913820 SGTC_2911 7942208 15.64 µM 0.816539886797379 0.218154488009927 no 754 0.207095710156558 973 1243384 SGTC_863 0466-0191 129 µM 0.816385325091062 0.218198012065801 no 755 0.207139893562316 1059 765160 YPR165W RHO1 SGTC_1530 rhein 70.4 µM 0.815186293761381 0.218535825186615 no 756 0.207482841101285 1083 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1367 1812-0510 76.9 µM 0.813553658700871 0.218996284939283 no 757 0.207950347385282 1012 1142582 YDR527W RBA50 SGTC_1115 galangin 695.678 nM 0.81247312980849 0.219301338206172 no 758 0.208260099384908 1100 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_225 nsc-122657 1.016 µM 0.812304924022302 0.21934884776467 no 759 0.208308342911189 909 275685 SGTC_665 3914-0008 307 µM 0.810912895351032 0.21974225183892 no 760 0.208707847146212 1027 1069549 SGTC_2870 9038528 12.99 µM 0.809294976967072 0.220200003666985 no 761 0.20917274740689 946 6463316 SGTC_496 calpeptin 138 µM 0.809240768394685 0.220215350165219 no 762 0.209188334501136 985 73364 A calpain inhibitor. SGTC_31 0508-1974 57.237 µM 0.808817448159689 0.220335213618915 no 763 0.209310079217615 1006 6810525 SGTC_1574 spiramycin 23.7 µM 0.808618644587482 0.220391517909408 no 764 0.209367268487414 1065 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2201 6605497 169.863 µM 0.807789585031049 0.220626409472258 no 765 0.209605860851251 1029 670741 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.807621960541484 0.220673918753469 no 766 0.209654120387716 933 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2818 7996756 12.99 µM 0.806571165148125 0.220971875861033 no 767 0.209956796014602 1002 2241621 SGTC_1385 3091-4834 14.1 µM 0.806461864512385 0.221002881696486 no 768 0.20998829417783 986 4072814 SGTC_762 1165-0429 115 µM 0.805126397023392 0.221381921185946 no 769 0.210373372226939 1030 5967793 SGTC_298 1391-0729 10 µM 0.804555935898774 0.221543945737657 no 770 0.210537989271574 1023 3237558 SGTC_2994 9053520 71.4286 µM 0.802725234664828 0.222064366046226 no 771 0.211066782076787 1037 4647384 SGTC_2365 9042475 200 µM 0.802572510902455 0.222107812918396 no 772 0.211110931050214 1049 6464479 SGTC_3351 9150312 21.596 µM 0.801842525455056 0.222315546264157 no 773 0.211322028021328 1018 4904905 SGTC_1441 4106-0040 13 µM 0.797290191576253 0.223613510858679 no 774 0.212641257735445 1053 2904180 SGTC_3187 9109394 49.47 µM 0.797154389432836 0.223652296941516 no 775 0.21268068583603 1039 17098090 SGTC_2299 7976368 114.88 µM 0.796868811767494 0.223733872485327 no 776 0.212763612922433 1030 2979718 SGTC_2939 9044578 71.43 µM 0.794859047832927 0.224308441736108 no 777 0.213347749170081 1041 2653634 SGTC_126 0417-1624 672.48 µM 0.793819681112359 0.224605913485978 no 778 0.213650206685087 1189 41912 YDL195W SEC31 SGTC_842 0271-0008 11.1 µM 0.793355829915366 0.224738742116946 no 779 0.213785268762479 1072 1221709 SGTC_2424 5537928 59.2 µM 0.792959637630625 0.224852231177895 no 780 0.213900669590581 1100 5382802 SGTC_2600 tangeritin 87.95 µM 0.792769794118143 0.224906623259406 no 781 0.2139559790722 1021 68077 A bioactive flavone. SGTC_2772 vinpocetine 57.06 µM 0.792491092493143 0.224986487596892 no 782 0.21403719177886 1024 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1951 sophoraflavanone G 9.2 µM 0.788506468673893 0.226130071817064 no 783 0.215200258179511 1061 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.788339354039914 0.226178105265434 no 784 0.215249117058914 1159 688801 SGTC_1042 0350-0096 82 µM 0.787960505552267 0.226287018328606 no 785 0.215359903862391 1025 3122515 SGTC_865 0488-0499 301 µM 0.78717498031281 0.226512939024011 no 786 0.215589720685665 1100 9634651 SGTC_3185 9108267 49.47 µM 0.784556931066575 0.227266820887772 no 787 0.216356695116599 1068 4910486 SGTC_2745 rifampicin 24.3 µM 0.782142137233799 0.227963425979419 no 788 0.217065522703842 965 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1487 3970-0795 2.82 µM 0.781483875085625 0.228153525582853 no 789 0.21725897847721 1077 3765103 SGTC_2327 6189656 200 µM 0.781465315307493 0.228158886755046 no 790 0.217264434428368 1063 5349088 SGTC_1466 k213-0079 57.5 µM 0.778746447055351 0.228945023073551 no 791 0.21806454484764 1063 3657981 SGTC_2360 9040895 200 µM 0.777349117717536 0.229349638868669 no 792 0.218476411787958 1012 4914414 SGTC_3111 9122088 49.47 µM 0.775576719836797 0.229863437079183 no 793 0.218999475211964 988 16876704 SGTC_2352 9027995 87.8 µM 0.775446446116644 0.229901227370982 no 794 0.219037949498478 1022 2997347 SGTC_2908 7930301 100 µM 0.774788138441011 0.230092244925243 no 795 0.219232429719284 1078 2223178 SGTC_301 4119-0100 24.5 µM 0.774532168451826 0.230166542313542 no 796 0.219308076319397 1092 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2238 6671620 73.2395 µM 0.77452546500179 0.230168488225201 no 797 0.219310057586018 1094 729941 SGTC_1434 4073-0095 163 µM 0.772122544536767 0.230866612862844 no 798 0.220020925401434 1113 24133745 SGTC_1091 telmisartan 47.6 µM 0.770454525149667 0.231351919871601 no 799 0.220515160159791 1138 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3304 9125678 46.087 µM 0.768994355764787 0.231777219946618 no 800 0.220948330609351 1035 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2323 6148992 148.28 µM 0.766934956328853 0.232377796023332 no 801 0.221560094385403 1006 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2152 5568786 200 µM 0.766901768886235 0.232387481453289 no 802 0.221569960944293 1077 5399883 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.763847773924698 0.233279720426828 no 803 0.222478981649081 1156 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1226 3909-7979 35.4 µM 0.763707326470345 0.233320798484913 no 804 0.222520836881699 1105 6615510 SGTC_726 3448-4391 34.2 µM 0.76309516078977 0.233499891511927 no 805 0.222703322925297 1142 1356692 SGTC_602 3130-1533 38.1 µM 0.763090265222802 0.233501324048939 no 806 0.222704782633154 1113 720941 SGTC_541 4513-1321 94 µM 0.762859265491353 0.233568924552604 no 807 0.222773665864213 1032 747515 SGTC_1900 st060200 72.8 µM 0.762545311375432 0.233660818490293 no 808 0.222867305234922 1103 688945 SGTC_2878 9043973 25.97 µM 0.762396767719446 0.23370430399848 no 809 0.22291161740319 1084 6465167 SGTC_2988 9073640 71.4286 µM 0.760376794012614 0.234296087600459 no 810 0.223514695229864 1081 9102229 SGTC_2267 7931562 200 µM 0.760257133165685 0.234331170162833 no 811 0.223550449939184 1027 934880 SGTC_1777 st045864 34.765 µM 0.759766457976355 0.234475058335183 no 812 0.223697097898191 1095 4691462 SGTC_2734 clemastine 41.6 µM 0.759224680999922 0.234633988630404 no 813 0.22385908215264 1037 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1776 st049249 45.9 µM 0.758519279823412 0.234841007339949 no 814 0.224070087779845 1135 1822314 SGTC_1617 st002906 78 µM 0.758154024990317 0.234948240730105 no 815 0.224179390306113 1098 5150859 SGTC_2029 5175081 200 µM 0.758067560741163 0.234973629308506 no 816 0.224205269168294 1143 1380876 SGTC_2199 6590217 200 µM 0.758016561758506 0.234988604898219 no 817 0.224220534025443 1054 703109 SGTC_3037 9091026 49.47 µM 0.757737697794076 0.235070501195842 no 818 0.224304013156547 1152 25236398 YIL048W NEO1 SGTC_135 0933-0004 26.348 µM 0.756972036269402 0.235295440429184 no 819 0.224533307944044 1041 21230617 YGL099W LSG1 SGTC_649 1123-0311 367 µM 0.756168242005118 0.235531710256814 no 820 0.224774165478125 1095 693629 YIL048W NEO1 SGTC_1788 fluconazole 20 µM 0.756012759110909 0.235577428494719 no 821 0.224820772945125 1036 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1903 st060211 78.3 µM 0.755352098607113 0.235771743896561 no 822 0.225018873269328 1128 688960 SGTC_2260 7964312 200 µM 0.755340814205404 0.235775063665303 no 823 0.225022257777923 1064 231951 SGTC_2882 9058044 58.44 µM 0.755029859394759 0.235866553893154 no 824 0.22511553319745 1090 18076804 SGTC_748 act1.228 77.9 µM 0.754191256489613 0.236113388145732 no 825 0.225367193508489 1100 4421505 YNR035C ARC35 SGTC_1081 sertraline 6 µM 0.753481128305459 0.236322518390358 no 826 0.225580423733383 1113 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_373 0844-0104 25.9 µM 0.751365933522942 0.236946039676499 no 827 0.226216229414596 1154 5375804 SGTC_2861 9024595 19.48 µM 0.750236018900908 0.237279488339035 no 828 0.226556284541961 1058 16482810 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.749025828750823 0.237636912731685 no 829 0.226920818953374 1137 688664 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.748916006862204 0.237669362762806 no 830 0.226953915952182 1151 688669 SGTC_18 0111-0177 500 nM 0.748497730999821 0.237792976639445 no 831 0.227079996585407 1214 721752 SGTC_2115 tiliquinol 12.7705 µM 0.748022217818581 0.237933548792333 no 832 0.227223378180084 1085 71208 A bioactive hydroxyquinoline. SGTC_3010 9080089 71.4286 µM 0.746074096811067 0.238509931607776 no 833 0.227811327952601 1120 17027233 SGTC_3027 9089541 49.47 µM 0.745672619846498 0.238628809922491 no 834 0.227932601423899 1124 9943819 SGTC_1684 st024538 14.6195 µM 0.745008015551146 0.238825672134176 no 835 0.228133437128342 1122 6732859 SGTC_651 3253-0966 34.4 µM 0.743835116240082 0.239173312857168 no 836 0.228488116326409 1141 781462 SGTC_1981 st071826 47 µM 0.742070230519659 0.239696935710857 no 837 0.229022392717218 1091 11838600 SGTC_3136 9095672 49.47 µM 0.741785068424956 0.239781598944153 no 838 0.229108784357806 979 17217380 SGTC_1278 0874-0585 172 µM 0.741637356954461 0.239825460172002 no 839 0.229153541657459 1133 766306 SGTC_1953 st076800 12.1 µM 0.741634221097723 0.239826391376156 no 840 0.229154491890578 1052 297591 SGTC_2342 7990637 118.86 µM 0.740209166007891 0.240249770764882 no 841 0.229586543350841 1158 2033102 YER133W GLC7 SGTC_390 dec-rvkr-cmk 16.7 µM 0.737779208064235 0.240972642007378 no 842 0.230324315016009 1156 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2808 7946468 45.46 µM 0.734477010699892 0.24195688272492 no 843 0.231329033188498 1121 2970879 SGTC_1573 oleylamine 1.06 µM 0.733678275527093 0.242195277867905 no 844 0.231572420951491 1150 5356789 An amine of the fatty acid oleic acid. SGTC_3080 9117754 49.47 µM 0.73327633028077 0.242315292925404 no 845 0.231694954255551 1167 9550191 SGTC_1669 st015249 58.4 µM 0.729709602957908 0.24338167677905 no 846 0.232783855003568 1230 722793 SGTC_1539 benzyladenosine 56 µM 0.729061377319961 0.243575755912932 no 847 0.232982059380376 1138 92208 A nucleotide analog. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.728953067860942 0.243608191975768 no 848 0.233015185702357 1165 676296 Flavone; oxidizing agent. SGTC_1911 st060208 74.3 µM 0.728584803593304 0.243718495661794 no 849 0.233127838464057 1151 688783 SGTC_282 k297-0036 65.7 µM 0.72771080888887 0.243980385234115 no 850 0.233395316152352 1123 5061378 SGTC_3259 9138485 49.47 µM 0.727513467438537 0.244039538938523 no 851 0.233455734161973 1262 17646153 SGTC_801 0866-0028 10.1 µM 0.725449319665909 0.244658736945483 no 852 0.234088212830686 1189 6849771 SGTC_16 erodoxin 22.806 µM 0.72471568223221 0.244879015318032 no 853 0.234313236160886 1199 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2060 5238662 140 µM 0.723265107401833 0.245314871761999 no 854 0.234758512720222 1108 790130 SGTC_40 0327-0103 19.753 µM 0.723131526073371 0.24535503010681 no 855 0.234799541101688 1099 409036 SGTC_1262 0737-0114 49.6 µM 0.722787926469639 0.245458342146506 no 856 0.234905093037923 1195 765919 SGTC_250 brefeldin a 552.239 µM 0.722163899473487 0.245646031637991 no 857 0.235096857789219 1063 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_723 4182-0001 115 µM 0.721963351707135 0.245706367037498 no 858 0.2351585048764 1114 744821 YLR208W SEC13 SGTC_957 1187-1561 14.1 µM 0.721764383552279 0.245766235068919 no 859 0.235219675222448 1157 1538454 SGTC_775 4577-0580 57.3 µM 0.720747853678724 0.246072223489254 no 860 0.235532332075524 1200 2006902 SGTC_2445 5742597 35.57 µM 0.719924673052965 0.246320160997734 no 861 0.235785687903678 1108 1774255 SGTC_623 k072-0108 16.9 µM 0.719856983878801 0.246340554564226 no 862 0.235806527739159 1129 5382803 SGTC_333 3486-0131 40.1 µM 0.719744274863011 0.24637451383111 no 863 0.235841230332128 1199 6744690 SGTC_1913 st060213 96.1 µM 0.718295264341712 0.246811324620679 no 864 0.236287624753191 1181 688959 SGTC_555 4296-0685 37 µM 0.718175311153221 0.246847503624808 no 865 0.236324599385824 1154 2908540 YHR072W ERG7 SGTC_1567 st069303 68.4 µM 0.718145513092515 0.246856491438922 no 866 0.236333784899039 1186 5581319 SGTC_3017 9080681 49.47 µM 0.716413922461088 0.247379081669963 no 867 0.236867900349292 1144 16451914 SGTC_937 3122-0005 46.7 µM 0.715383665076298 0.247690291423601 no 868 0.237186001635428 1171 759535 SGTC_819 1013-0258 27.7 µM 0.715098516922201 0.247776463028124 no 869 0.237274085154094 1191 5753198 SGTC_589 1227-0070 34.1 µM 0.715039566808181 0.247794279714293 no 870 0.237292297344285 1151 2841384 SGTC_1296 1068-0102 11.9 µM 0.713313280538261 0.248316324021203 no 871 0.237825960656805 1121 767053 SGTC_2346 9031566 143.75 µM 0.713115907106937 0.248376048829834 no 872 0.237887018487694 1137 4771086 SGTC_1848 st056003 16.4 µM 0.712079414357094 0.248689815123267 no 873 0.23820780045691 1233 146492 SGTC_1980 st071811 45.7 µM 0.711457279374418 0.248878248679961 no 874 0.238400457465859 1201 4974850 SGTC_217 ketoconazole 989 nM 0.709768819475042 0.249390035759073 no 875 0.23892375387179 1128 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_370 0180-0345 38.7 µM 0.708753447047564 0.249698073228961 no 876 0.239238745643103 1116 3989527 SGTC_2414 st077232 92.9 µM 0.708603428598097 0.249743602034041 no 877 0.239285304031307 1118 729801 SGTC_3339 9145883 14.936 µM 0.708290876267146 0.24983847208565 no 878 0.239382320883278 1111 2030670 SGTC_2382 9035899 200 µM 0.707129431919355 0.250191176734315 no 879 0.239743023645062 1218 6462679 SGTC_2571 chrysanthemic acid 100 µM 0.706952011335198 0.250245078635389 no 880 0.239798150185108 1124 2743 An insecticide. SGTC_3073 9114972 49.47 µM 0.705617946705099 0.250650576108661 no 881 0.240212880252046 1096 41905075 SGTC_2781 5567276 71.43 µM 0.705453382057529 0.250700620687952 no 882 0.240264066692737 1157 2853274 SGTC_584 0986-0246 15.4 µM 0.704618629967422 0.250954552658549 no 883 0.24052380077575 1282 53315 YDR232W HEM1 SGTC_3134 9127454 49.47 µM 0.704416648598659 0.251016015930218 no 884 0.240586670478426 1270 24262820 SGTC_1340 1486-1359 257 µM 0.70249744211901 0.251600430895048 no 885 0.241184498169062 1158 4309068 SGTC_1780 st038448 24.544 µM 0.699696550931729 0.252454614682981 no 886 0.242058415450941 1201 728868 YDL195W SEC31 SGTC_1693 xanthone 101.9 µM 0.696633041649924 0.253390635717746 no 887 0.243016236138711 1211 7020 An insecticide. SGTC_1957 st077035 62.4 µM 0.694970067955908 0.253899501527563 no 888 0.243537029928366 1253 705593 SGTC_1838 st055369 84.5 µM 0.693793338842928 0.254259901474581 no 889 0.243905910298864 1184 676036 SGTC_2671 danthron 100 µM 0.69250130853907 0.254655923733421 no 890 0.24431128221759 1169 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_583 1488-1091 88.9 µM 0.690139999041258 0.255380526273769 no 891 0.245053075670017 1297 4303273 SGTC_2256 7954252 200 µM 0.68857041364095 0.25586277213653 no 892 0.245546822501973 1161 2972920 SGTC_2979 9012552 45.46 µM 0.687614302751219 0.25615676433428 no 893 0.245847849453231 1250 17100905 SGTC_710 3448-4187 58 µM 0.686566629161173 0.256479113071346 no 894 0.246177931795359 1231 3946412 SGTC_3219 9131112 49.47 µM 0.68495570775075 0.256975174168346 no 895 0.24668593553971 1160 17612988 YMR079W SEC14 SGTC_1766 st045414 44.774 µM 0.684590216676664 0.257087791548505 no 896 0.246801271160166 1262 253960 SGTC_1166 k206-0078 225 µM 0.684146207437952 0.257224636956046 no 897 0.246941423070438 1226 5404595 SGTC_1041 0206-0046 107 µM 0.683278253825159 0.257492253022865 no 898 0.247215516358185 1195 50494 SGTC_3024 9090631 49.47 µM 0.683153215897447 0.257530817872203 no 899 0.247255015806663 1176 25236383 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.68294571281625 0.257594823673682 no 900 0.247320573421325 1213 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1803 st050068 52.4 µM 0.682730992576396 0.257661064355046 no 901 0.247388420974859 1305 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2825 7998094 58.44 µM 0.682550895334236 0.257716630743457 no 902 0.247445335983359 1181 2987815 SGTC_2301 7769476 200 µM 0.682502659725383 0.257731514196127 no 903 0.24746058077003 1208 977820 SGTC_872 0588-0139 234 µM 0.681870495385437 0.257926614397766 no 904 0.247660421677329 1236 2047100 SGTC_1999 st074831 12.5 µM 0.680865425178094 0.258236959454439 no 905 0.247978323617729 1208 17112523 SGTC_2511 berberine 10.47 µM 0.680652947193588 0.258302593072273 no 906 0.248045557902782 1218 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2054 5233173 129 µM 0.680367787497873 0.258390691370913 no 907 0.248135806102034 1224 6889 SGTC_1961 st076550 68.7 µM 0.680061589086759 0.258485306778791 no 908 0.248232732193825 1198 1579337 SGTC_614 0462-0418 107 µM 0.678489802348765 0.25897127172412 no 909 0.248730593719214 1116 5188303 SGTC_1285 0929-0069 65.5 µM 0.678439077506456 0.258986962696067 no 910 0.248746669602968 1222 1206237 SGTC_1504 k297-0033 30 µM 0.6762181641141 0.259674450827305 no 911 0.24945107085462 1136 4388117 SGTC_1144 3486-0183 12.5 µM 0.676206276557779 0.259678133176771 no 912 0.24945484404972 1236 6744069 SGTC_600 1495-0418 41.6 µM 0.675981489117759 0.259747769542458 no 913 0.249526198894349 1230 5377768 SGTC_2938 9059746 27.26 µM 0.67408397785822 0.260335978823782 no 914 0.250128962586311 1195 6471769 SGTC_796 1234-0020 70.7 µM 0.672781812157262 0.260740033688569 no 915 0.250543055168499 1198 46495034 SGTC_871 0574-0004 149 µM 0.671969134211338 0.260992366630626 no 916 0.250801673141178 1204 9551173 SGTC_2972 9093619 59.92 µM 0.670223317719858 0.261534859281412 no 917 0.25135772076969 1231 25236256 SGTC_1759 st043059 70 µM 0.670105639302331 0.261571447327172 no 918 0.251395225118004 1222 669426 SGTC_929 2805-0021 398 µM 0.668834309656519 0.261966890888941 no 919 0.251800588945461 1271 3098024 SGTC_2953 9074162 66.49 µM 0.666446503562739 0.262710438943175 no 920 0.252562873372452 1200 16451992 SGTC_2688 kanamycin b 96.69 µM 0.665230202025763 0.26308960233641 no 921 0.252951632943298 1346 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2827 7993847 71.43 µM 0.664061096044026 0.263454316628483 no 922 0.253325604271959 1206 2985692 SGTC_2254 7938975 95.19 µM 0.662339253098949 0.263991932287878 no 923 0.253876912823849 1313 2969277 SGTC_1193 1488-0126 41.5 µM 0.662136790089361 0.264055184574978 no 924 0.253941779826999 1271 1384710 SGTC_3140 9094243 49.47 µM 0.660482333067409 0.264572349392285 no 925 0.254472176085677 1273 19291112 SGTC_1070 indatraline 8.81 µM 0.660268541407525 0.264639215858097 no 926 0.254540757090279 1237 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2140 5586273 200 µM 0.659661480628662 0.264829129832761 no 927 0.254735545417239 1248 854421 SGTC_2866 9034245 58.44 µM 0.659624078665491 0.264840832994891 no 928 0.254747549182384 1238 6462273 SGTC_2385 9074692 200 µM 0.659503469933375 0.264878573541136 no 929 0.254786259298629 1233 17046906 SGTC_2915 7971052 15.16 µM 0.655700310844468 0.266070047870662 no 930 0.256008484413499 1137 5741558 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.653979914947264 0.266609913083841 no 931 0.256562372870732 1225 77254 SGTC_3314 9135860 59.4275 µM 0.653154464923593 0.266869138175249 no 932 0.256828351279516 1253 25252478 SGTC_284 0988-0104 32.6 µM 0.651698768190764 0.267326596615957 no 933 0.257297758699306 1272 4666532 SGTC_2517 totarol 10 µM 0.651648337635228 0.267342451704552 no 934 0.257314028643788 1225 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.651537602131183 0.267377268000939 no 935 0.257349756092995 1274 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1482 3346-2049 8.48 µM 0.649229429390131 0.268103499798318 no 936 0.258095046126417 1274 3826804 SGTC_10 0279-0212 42.575 µM 0.646283433457953 0.269031853114478 no 937 0.259047907353279 1284 39851 YBR002C RER2 SGTC_1252 0493-0875 34.8 µM 0.644824045314233 0.269492337846173 no 938 0.259520608870289 1278 3960963 SGTC_2844 9010103 25.97 µM 0.643813659433537 0.269811378925939 no 939 0.25984813755794 1278 2480525 SGTC_2969 9091408 28.7 µM 0.641929939546001 0.270406689880227 no 940 0.260459336843654 1238 4286311 SGTC_2153 5569715 200 µM 0.641910060323939 0.270412975798494 no 941 0.260465790881079 1304 2054701 SGTC_2894 9048625 32.47 µM 0.641290001561019 0.270609078411979 no 942 0.260667142033342 1355 4092861 SGTC_1158 4092-0494 91.8 µM 0.640739103898988 0.270783367388981 no 943 0.260846101742411 1363 1148199 SGTC_2663 amphotericin b 100 µM 0.639919647249326 0.271042724725723 no 944 0.261112420011516 1258 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2408 sulbentine 18.36 µM 0.639677872088674 0.271119270025225 no 945 0.261191022113745 1308 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1203 3992-3522 103 µM 0.639311579577856 0.271235257682767 no 946 0.261310128480886 1487 5322312 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.638564920696614 0.271471766105772 no 947 0.261553003949836 1262 803109 SGTC_1172 0370-0043 85 µM 0.63849365159237 0.27149434636721 no 948 0.261576192637405 1321 376585 SGTC_2646 retinol 96.75 µM 0.638424901101038 0.271516129540481 no 949 0.261598562848815 1293 445354 A vitamin A analog and teratogen. SGTC_484 loperamide 105 µM 0.637521449717165 0.271802463449691 no 950 0.261892621387967 1260 3955 An opioid-receptor agonist. SGTC_148 3253-0744 288.01 µM 0.637367817240267 0.271851169655873 no 951 0.261942643086019 1256 6893655 SGTC_1763 st044482 94.5 µM 0.637236180736033 0.271892905918459 no 952 0.261985506940403 1290 88505 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.637150123958755 0.271920192536942 no 953 0.262013530937694 1271 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1357 1503-1303 39.5 µM 0.635748717725167 0.27236473774008 no 954 0.262470108663195 1282 292895 SGTC_1021 4476-0760 85.3 µM 0.634737125625426 0.272685852774028 no 955 0.262799938000726 1258 746768 SGTC_3169 9102970 49.47 µM 0.634340453770116 0.272811821680708 no 956 0.262929330589031 1345 17027839 SGTC_1712 st032288 53.4 µM 0.633440238908768 0.273097805027643 no 957 0.263223097440545 1272 2883011 SGTC_921 1561-0023 372 µM 0.632360079355219 0.273441149805606 no 958 0.263575806730317 1292 24050882 SGTC_417 st075190 100 µM 0.631904094487391 0.273586155499771 no 959 0.263724773848508 1315 222757 SGTC_2470 5664817 21.68 µM 0.630114958694131 0.27415547781875 no 960 0.264309686697699 1324 2859561 SGTC_3223 9129970 49.47 µM 0.629964617552328 0.274203344633762 no 961 0.264358867010123 1357 17248386 SGTC_1667 st014849 34.6 µM 0.626628313019836 0.275266644875932 no 962 0.265451452316952 1318 5348460 SGTC_202 3594-0513 34.79 µM 0.626425197003336 0.275331444651983 no 963 0.26551804341489 1272 708429 SGTC_728 3030-5151 22.5 µM 0.626334364960603 0.275360425081513 no 964 0.265547825223819 1325 3125388 SGTC_1767 st044992 70.3 µM 0.625877664399594 0.275506160483289 no 965 0.265697592865751 1250 9600693 SGTC_25 0118-0223 35.662 µM 0.625722361750429 0.275555726967185 no 966 0.265748531641007 1339 5333628 SGTC_1492 4158-0558 28.5 µM 0.625694464054458 0.275564631276696 no 967 0.265757682521117 1326 3967268 SGTC_3162 9099653 49.47 µM 0.625254558425988 0.275705057843855 no 968 0.265901999554884 1283 25237511 SGTC_2505 galangin 7.89 µM 0.621978161389163 0.276752053761031 no 969 0.266978114051472 1265 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1448 4255-0083 152 µM 0.619854848899822 0.277431611955361 no 970 0.267676677032959 1397 5399660 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.619397594700805 0.277578061119854 no 971 0.26782723265604 1258 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1036 k216-0215 33.5 µM 0.618521922140561 0.277858626516284 no 972 0.268115675827498 1298 622330 SGTC_961 1252-1571 372 µM 0.618008667516987 0.278023137570071 no 973 0.268284812573707 1363 6813498 SGTC_2334 9017922 200 µM 0.615723855357201 0.278756053631719 no 974 0.269038395023098 1364 3163164 SGTC_2257 7960413 200 µM 0.615681882160297 0.27876952647621 no 975 0.269052248658763 1298 2974689 YIL048W NEO1 SGTC_2157 5649910 96.377 µM 0.612269218917266 0.279866005727363 no 976 0.270179825759724 1296 2858091 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.611615667114942 0.280076228517328 no 977 0.270396034964127 1317 16486 A toxic proline analog. SGTC_3235 9132602 49.47 µM 0.611582423304715 0.280086923833564 no 978 0.270407035053107 1348 4912240 SGTC_2228 7354201 200 µM 0.609736128755323 0.280681230817852 no 979 0.271018308846143 1337 753451 SGTC_2995 9067767 71.4286 µM 0.609244896846705 0.280839456994762 no 980 0.271181062617439 1332 11673567 SGTC_2693 st077581 40.7 µM 0.608582199983041 0.281052980471374 no 981 0.271400702930331 1334 25238761 SGTC_903 1134-0042 114 µM 0.60750833155802 0.281399151442559 no 982 0.271756807588822 1317 701009 SGTC_2435 5706476 10.6 µM 0.60519324071177 0.28214614061907 no 983 0.272525303233646 1358 5725375 SGTC_2364 9055074 200 µM 0.603194934475786 0.282791682433431 no 984 0.273189508562671 1296 6470630 SGTC_2232 chlorophetanol 41.5365 µM 0.600954659743145 0.283516233340967 no 985 0.273935092774969 1396 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2005 4024620 188 µM 0.600376755473659 0.28370328370653 no 986 0.274127587748715 1326 236743 SGTC_920 mycophenolic acid 780.421 nM 0.599772463756995 0.283898938091726 no 987 0.274328943599459 1345 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2367 9070478 135.38 µM 0.598978338609324 0.284156153900568 no 988 0.274593664768496 1352 572802 SGTC_824 1304-0008 100 µM 0.598792772780731 0.284216274421608 no 989 0.274655541190448 1350 768245 SGTC_2557 derrustone 83.84 µM 0.59758988109906 0.284606140541224 no 990 0.275056808843256 1320 629853 An antioxidant. SGTC_3289 9119912 71.43 µM 0.59673608579679 0.284883016791241 no 991 0.275341797992017 1361 17014829 SGTC_1176 0848-0131 83.3 µM 0.593977076041762 0.285778610174638 no 992 0.276263722777577 1398 6769040 SGTC_2864 9034755 47.6 µM 0.593581343465018 0.285907177396411 no 993 0.276396081159674 1340 4930451 SGTC_3352 9151559 45.5865 µM 0.592248358126888 0.286340445326194 no 994 0.276842145735152 1304 17159339 SGTC_742 0kpi-0133 140 µM 0.589969270802344 0.287081951453123 no 995 0.277605625679506 1414 2728852 SGTC_1152 3909-8331 15.9 µM 0.589839951715107 0.287124052951622 no 996 0.277648977584025 1333 16001939 SGTC_2472 5377652 49.4 µM 0.589468431064007 0.287245022556477 no 997 0.277773541614085 1334 1610903 SGTC_1733 st037357 54.9 µM 0.588157496709989 0.287672064138355 no 998 0.278213291654751 1292 1272339 YGL099W LSG1 SGTC_1801 st050089 28.441 µM 0.58701104636154 0.288045770209991 no 999 0.278598143940449 1364 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_860 0443-0016 25.1 µM 0.586650035536309 0.288163495587569 no 1000 0.278719385433386 1369 5337942 SGTC_372 0155-0182 15.9 µM 0.585409310682092 0.288568268067925 no 1001 0.279136264880129 1360 771486 SGTC_1564 D-Arginine 115 µM 0.584807269276524 0.288764773760703 no 1002 0.279338657975756 1291 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_613 3914-0030 117 µM 0.584589504210465 0.288835867565853 no 1003 0.279411883361953 1229 1145395 SGTC_870 0573-2213 57.6 µM 0.584525381518091 0.288856803284274 no 1004 0.279433446948436 1344 3916321 SGTC_1859 st055998 20 µM 0.582433385100326 0.289540220435754 no 1005 0.280137399787526 1436 676301 SGTC_409 arachidonic acid 100 µM 0.581822975199835 0.289739773234809 no 1006 0.280342963402302 1385 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1804 st050076 49.1 µM 0.580484251841244 0.290177649230287 no 1007 0.280794051824078 1385 3895976 SGTC_2213 7173844 200 µM 0.579837397349731 0.290389336514001 no 1008 0.281012137836211 1341 892728 SGTC_2834 9001755 58.44 µM 0.578721459572739 0.290754704177952 no 1009 0.281388566851179 1397 2989575 SGTC_1439 4092-1168 46 µM 0.578505659599449 0.290825383748869 no 1010 0.281461388739145 1374 2886240 SGTC_2638 epoxomicin 18 µM 0.575950329271836 0.291662924595601 no 1011 0.282324377776121 1408 9915668 A protesome inhibitor. SGTC_272 doxorubicin 8.13 µM 0.575820285119467 0.291705578209568 no 1012 0.282368330453859 1360 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3143 9086658 49.47 µM 0.575075694402778 0.291949854953392 no 1013 0.282620052616665 1417 25236626 SGTC_2935 9038016 29.96 µM 0.574848155041741 0.292024522443523 no 1014 0.282696997864118 1347 6463195 SGTC_1884 5633444 25 µM 0.573981472262839 0.292309007496488 no 1015 0.282990169516845 1392 5724239 SGTC_1925 st057770 10.1 µM 0.573545894707457 0.292452032686635 no 1016 0.283137566858285 1291 5989122 SGTC_2682 pyrogallin 40.03 µM 0.572423954592465 0.292820579951373 no 1017 0.283517395527606 1388 822798 An ATP competetive kinase inhibitor. SGTC_179 1273-0063 6.77 µM 0.572253017987179 0.292876750015857 no 1018 0.283575286910898 1337 3108139 SGTC_1402 3909-7673 35.9 µM 0.572050450459208 0.292943320530602 no 1019 0.283643898123101 1363 5328014 SGTC_1438 4092-1045 4 µM 0.569505571422716 0.293780251114036 no 1020 0.284506545420538 1361 1351342 SGTC_1774 st048371 48.465 µM 0.569362420868079 0.293827361672428 no 1021 0.284555106910747 1343 4242727 SGTC_619 1652-1634 108 µM 0.569020700249728 0.293939835364394 no 1022 0.284671046056168 1363 5400454 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.56784249669626 0.294327781056386 no 1023 0.28507096037917 1359 688803 SGTC_532 1548-0774 215 µM 0.566741565436383 0.294690496941365 no 1024 0.285444888283178 1497 5932993 SGTC_1425 4048-4433 7.33 µM 0.564286574907687 0.295500066472616 no 1025 0.28627955824921 1424 23734946 SGTC_3077 9117319 49.47 µM 0.563406552882124 0.295790515608998 no 1026 0.286579038030537 1398 17154678 SGTC_1775 st081588 35.1725 µM 0.5625850952824 0.296061753989582 no 1027 0.28685872181437 1394 1426443 YGL099W LSG1 SGTC_1477 0139-0234 16 µM 0.561079708629478 0.296559116033208 no 1028 0.28737160013981 1399 620880 SGTC_329 k048-0121 21.3 µM 0.560144785922774 0.296868196059953 no 1029 0.287690342221743 1394 6832902 SGTC_2803 7707263 71.43 µM 0.558114144123096 0.297540021760927 no 1030 0.288383221407533 1399 2199229 SGTC_1154 4088-0362 150 µM 0.556767516473459 0.297985927879508 no 1031 0.28884314022213 1382 6618304 SGTC_174 3553-0389 74.3 µM 0.555805840751327 0.298304551942586 no 1032 0.289171796123992 1416 738071 SGTC_525 k781-2675 26.7 µM 0.554787366663375 0.298642163554559 no 1033 0.289520054641998 1422 3651118 YDL195W SEC31 SGTC_2732 terfenadine 20 µM 0.552758888182307 0.299315096261936 no 1034 0.290214261709311 1402 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3 0833-0587 95.581 µM 0.550779010848877 0.299972568383629 no 1035 0.290892587056072 1344 5382644 SGTC_3233 9132340 49.47 µM 0.548846668039273 0.300614884802677 no 1036 0.291555340284058 1376 17682950 SGTC_318 1488-0629 67.2 µM 0.548341571361609 0.300782882726221 no 1037 0.291728693904515 1395 3662576 SGTC_1798 st045719 60.953 µM 0.545731376399771 0.301651722082901 no 1038 0.292625300341961 1361 3980186 SGTC_1230 0170-0365 3.77 µM 0.545312057612435 0.301791403279478 no 1039 0.292769456327958 1473 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1016 4226-1401 38 µM 0.545002045284417 0.301894691591362 no 1040 0.292876055465713 1406 2901613 SGTC_273 hydroxyurea 18.1 mM 0.544719327458957 0.301988899906632 no 1041 0.292973284969054 1442 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2266 7929956 200 µM 0.544428557095498 0.302085805291309 no 1042 0.293073299441667 1407 2967153 SGTC_3250 9135583 49.47 µM 0.543676317494116 0.302336569837201 no 1043 0.293332116070714 1479 7699353 SGTC_2843 9000894 45.46 µM 0.543409997779307 0.302425371829003 no 1044 0.293423771792669 1317 2242070 SGTC_1406 3909-7906 11.9 µM 0.542210305708545 0.302825543648585 no 1045 0.293836818297544 1437 X1406 SGTC_1465 k213-0056 144 µM 0.541618559494896 0.303023015042579 no 1046 0.294040651837505 1383 24048857 YMR208W ERG12 SGTC_1736 st036774 51 µM 0.541383976933201 0.303101313440821 no 1047 0.294121474488054 1506 1272247 SGTC_1277 0873-0036 22 µM 0.540831649325809 0.303285703738249 no 1048 0.294311812973017 1520 5965735 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.539798476340452 0.303630755091957 no 1049 0.294668008981885 1511 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2246 7293507 91.5585 µM 0.536426333309876 0.304758175508819 no 1050 0.295831967959917 1525 887656 SGTC_176 1486-1328 72.834 µM 0.536413477650647 0.304762477145507 no 1051 0.295836409372302 1413 22310231 SGTC_1359 1582-0056 520 nM 0.536146364531284 0.304851862066939 no 1052 0.295928699356725 1478 3661189 SGTC_1341 1486-1360 280 µM 0.534669791145078 0.305346182611584 no 1053 0.296439107098439 1412 3976547 SGTC_718 1130-0073 349 µM 0.533846626414884 0.305621912225145 no 1054 0.296723825853485 1499 6740020 SGTC_1727 st034309 9.9045 µM 0.530561525902861 0.306723395772905 no 1055 0.297861331463705 1557 870305 SGTC_210 3551-0445 56.827 µM 0.530507357215258 0.306741573030797 no 1056 0.297880104678178 1475 2865180 YOR207C RET1 SGTC_1972 st070201 17.4 µM 0.530188474705857 0.306848589310407 no 1057 0.297990630561709 1489 2829099 SGTC_2389 9091542 195.52 µM 0.528075709471913 0.30755804428199 no 1058 0.298723394684669 1422 3626624 YOL127W RPL25 SGTC_2601 securinine 100 µM 0.52791792429152 0.307611056621259 no 1059 0.298778151707802 1400 442872 A GABA receptor antagonist. SGTC_606 k015-0008 38.6 µM 0.527423926113518 0.307777055086355 no 1060 0.298949615991352 1549 1970475 SGTC_1004 4084-0029 199 µM 0.52485286124079 0.308641646165986 no 1061 0.299842740414135 1493 716894 YLR208W SEC13 SGTC_3149 9097855 49.47 µM 0.52157628641381 0.309745023104354 no 1062 0.300982688831548 1564 25236625 YMR079W SEC14 SGTC_21 0849-0113 22.993 µM 0.521521421205615 0.309763513439706 no 1063 0.301001793529681 1412 1560156 SGTC_1711 st032263 62.8 µM 0.521300994581509 0.309837805117501 no 1064 0.301078554131431 1488 3958979 SGTC_502 l-744,832 89.3 µM 0.521211706506965 0.309867900611344 no 1065 0.301109650010677 1499 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_405 ebelactone b 50 µM 0.520505918332345 0.310105838844557 no 1066 0.301355501992998 1436 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1486 3970-0793 4.53 µM 0.517533759660314 0.311108697048119 no 1067 0.302391804312692 1502 2844330 SGTC_2555 cholic acid 100 µM 0.517185999777007 0.311226129192898 no 1068 0.302513162098695 1455 6708657 Influences liver metabolism. SGTC_1015 4130-4525 82 µM 0.513901675749235 0.312336131655332 no 1069 0.303660367923001 1426 1363237 SGTC_2507 purpurin 79.67 µM 0.512572214408893 0.31278593492777 no 1070 0.3041252968104 1392 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2842 9000675 19.48 µM 0.510359995661861 0.313535023877396 no 1071 0.304899638919024 1402 2989072 SGTC_2784 7567673 72.73 µM 0.509774278611209 0.313733485050585 no 1072 0.305104803817433 1462 3471247 SGTC_2962 9082311 13.18 µM 0.508355777877796 0.314214345410117 no 1073 0.305601929846953 1418 16459453 SGTC_2716 st080858 38.6235 µM 0.50484176064407 0.315406926674027 no 1074 0.306834991002428 1465 5296050 SGTC_1484 3473-2379 286 µM 0.501052894403523 0.31669494343342 no 1075 0.308166948738833 1542 671917 SGTC_2002 4023503 131 µM 0.496846450894771 0.318127521863774 no 1076 0.309648667951174 1586 4736863 YCR052W RSC6 SGTC_431 k089-0097 107 µM 0.49617669295122 0.318355871770382 no 1077 0.309884876701896 1432 5499420 SGTC_1157 4092-0394 27.6 µM 0.495501334387953 0.318586201079267 no 1078 0.310123140163607 1585 3659885 SGTC_2171 5739187 198.077 µM 0.495488455348043 0.318590594124449 no 1079 0.310127684606063 1422 2262761 SGTC_1191 1487-1166 10.6 µM 0.494175817288716 0.31903846909522 no 1080 0.310591008408983 1582 3955771 SGTC_998 3996-0085 177 µM 0.493919241070301 0.319126044362828 no 1081 0.310681607642457 1614 715391 SGTC_802 4112-3352 742 µM 0.488642349457013 0.320929399846971 no 1082 0.312547462639415 1594 704594 SGTC_1805 st050013 60.3 µM 0.487447284665204 0.321338397571549 no 1083 0.312970695798929 1533 4037144 SGTC_2306 7482397 179.52 µM 0.486697753803891 0.321595026865275 no 1084 0.313236268630609 1614 891448 SGTC_3057 9095946 49.47 µM 0.486220296530478 0.321758546229295 no 1085 0.313405491219799 1525 24540043 SGTC_2284 7945075 39.21 µM 0.486154516232993 0.321781077344632 no 1086 0.313428808453542 1616 1245402 SGTC_1906 st060206 94.7 µM 0.485863383607926 0.321880804171081 no 1087 0.313532015593261 1555 5133468 SGTC_1540 guanosine 70.6 µM 0.485474482769991 0.322014041296337 no 1088 0.313669904550208 1487 6802 Guanosine is a purine nucleoside SGTC_2936 9038235 15.59 µM 0.485175379740411 0.322116529329521 no 1089 0.313775972445858 1480 4749415 SGTC_1845 st056753 3.01 µM 0.485061708605306 0.32215548243637 no 1090 0.313816286533013 1429 5375839 SGTC_2883 9059145 45.46 µM 0.484560378308764 0.322327302849646 no 1091 0.313994112568425 1484 16476510 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.484417739848296 0.322376196120868 no 1092 0.31404471551576 1550 279621 SGTC_996 3970-0799 1.8 µM 0.484111783354921 0.322481081521417 no 1093 0.314153269564876 1577 6615648 YGL040C HEM2 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.483748953291015 0.322605482149781 no 1094 0.314282023324881 1532 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1189 1431-2119 7.28 µM 0.482777664215306 0.322938597944633 no 1095 0.31462680585029 1507 3107275 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.481929026167898 0.323229765353486 no 1096 0.314928182809151 1476 688667 SGTC_2605 digitonin 300 nM 0.47946700164879 0.324075097552907 no 1097 0.315803219001352 1556 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.478245820709072 0.324494725217735 no 1098 0.316237626634667 1475 6312947 SGTC_2082 5219693 150 µM 0.477677385516906 0.32469012953509 no 1099 0.316439921248289 1491 2834649 SGTC_1295 1013-0063 9.78 µM 0.476905410481279 0.324955579631382 no 1100 0.316714739539641 1605 6826038 SGTC_3323 9138564 53.9225 µM 0.473694570072143 0.326060606556219 no 1101 0.317858862999364 1636 43912313 YNL103W MET4 SGTC_2021 4019055 173 µM 0.473663900510732 0.326071169028619 no 1102 0.317869799940295 1514 44827708 YER133W GLC7 SGTC_3333 9141820 12.094 µM 0.472703962390178 0.326401838320457 no 1103 0.318212199632432 1519 1939433 SGTC_3086 9117350 49.47 µM 0.472091278937093 0.326612960382178 no 1104 0.318430818549957 1459 2679265 SGTC_966 1300-0360 30.2 µM 0.471177773780962 0.326927844478905 no 1105 0.318756894684846 1531 70588 SGTC_2443 5493264 126.67 µM 0.469231884780552 0.327599000767803 no 1106 0.31945194849998 1624 5340055 SGTC_1821 st053465 65.6 µM 0.467119708835631 0.328328142039497 no 1107 0.320207117059448 1488 675086 SGTC_2343 7990716 14.84 µM 0.464772089802215 0.329139328200908 no 1108 0.321047338446162 1570 6456862 SGTC_337 1315-0038 354 µM 0.464214796177661 0.329332011432086 no 1109 0.321246930715426 1521 1626437 SGTC_3315 9136395 68.55 µM 0.463678174064315 0.329517590371877 no 1110 0.321439168378317 1600 16876844 SGTC_515 4092-1064 102 µM 0.463405861200706 0.329611779843744 no 1111 0.32153673910359 1659 717353 SGTC_1250 0485-0349 40.2 µM 0.461832904481877 0.3301560564675 no 1112 0.322100576229931 1521 6842794 YDL195W SEC31 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.46131338015055 0.330335902045786 no 1113 0.322286893359694 1591 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2502 avocadyne acetate 18.59 µM 0.460150681028129 0.330738539699778 no 1114 0.322704034166631 1490 3952079 SGTC_1516 st013856 110 µM 0.456750752489788 0.331917042875681 no 1115 0.32392510349047 1524 5281404 A mutagen and neurotoxin. SGTC_3128 9127691 49.47 µM 0.456499106772388 0.332004336105547 no 1116 0.324015556502928 1553 41316314 SGTC_1944 st076371 56.9 µM 0.4561635501362 0.332120751329264 no 1117 0.324136187114077 1501 24208455 SGTC_3114 9122766 49.47 µM 0.455310404730155 0.33241680744071 no 1118 0.324442970938239 1482 17176985 SGTC_1979 st071809 45.3 µM 0.454396475074992 0.332734072759319 no 1119 0.324771744488951 1608 4976333 SGTC_1179 1021-1431 9.29 µM 0.45416331644814 0.332815031601163 no 1120 0.32485564195215 1564 2840958 SGTC_3131 9127911 49.47 µM 0.454033728370326 0.332860031379792 no 1121 0.3249022754686 1581 45595681 SGTC_77 0828-0286 12.516 µM 0.452838918964552 0.333275045242753 no 1122 0.325332368324058 1481 745345 SGTC_1039 k821-0043 94 µM 0.452774270686118 0.333297506477961 no 1123 0.325355646261856 1651 15992768 SGTC_693 4161-2696 114 µM 0.452041541175206 0.333552125945723 no 1124 0.325619528149994 1639 805759 SGTC_1949 st076024 69.1 µM 0.451173480752845 0.33385387140366 no 1125 0.325932260618886 1501 2921930 SGTC_773 4358-1457 44.6 µM 0.450904476895312 0.333947401337723 no 1126 0.326029198377033 1702 1186886 SGTC_1255 0566-0045 221 µM 0.450032611020217 0.334250611202258 no 1127 0.326343463222128 1611 2788469 SGTC_2737 bleomycin 30.5 nM 0.449638111249084 0.334387842434797 no 1128 0.326485701561334 1569 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1932 st074806 40.9 µM 0.448726051608049 0.334705197472672 no 1129 0.326814644583808 1629 17251235 SGTC_2338 7999974 200 µM 0.446962457363415 0.335319182443921 no 1130 0.327451083417262 1683 315925 SGTC_3308 9128332 17.569 µM 0.446773751133016 0.335384905505397 no 1131 0.327519212718173 1674 17332805 YDL196W YDL196W SGTC_1814 st052110 31.539 µM 0.445692083693947 0.335761728407309 no 1132 0.327909841840665 1646 674163 SGTC_1679 SEC14.276 6.7 µM 0.444157663898576 0.336296560984963 no 1133 0.328464299209437 1691 1005053 YMR079W SEC14 SGTC_3009 9080819 71.4286 µM 0.443994432764 0.336353475845317 no 1134 0.328523304487434 1548 17027216 SGTC_3053 9095903 49.47 µM 0.443884011675221 0.336391979210567 no 1135 0.328563222257389 1617 17174018 SGTC_1076 itraconazole 331 nM 0.44365750992945 0.336470964777906 no 1136 0.328645109881812 1560 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_123 0083-0120 66.675 µM 0.443236605297776 0.336617761579163 no 1137 0.32879730221857 1491 16001701 SGTC_377 3970-0964 33.1 µM 0.442496903718281 0.336875803919653 no 1138 0.329064835185942 1612 16481235 SGTC_1293 1000-1278 195 µM 0.44183750422868 0.337105897905443 no 1139 0.329303398582982 1637 678847 SGTC_635 k038-0028 24.7 µM 0.440968641155985 0.337409176173398 no 1140 0.32961784970501 1628 4035102 SGTC_882 0843-0131 351 µM 0.440289147040465 0.337646428492923 no 1141 0.329863850093135 1583 5425421 SGTC_985 1493-0307 8.71 µM 0.438989497056435 0.338100394285731 no 1142 0.330334573326994 1670 3278274 SGTC_2820 7989630 71.43 µM 0.437771395948414 0.338526089019161 no 1143 0.330776004081034 1624 2984098 SGTC_1507 4075-3230 155 µM 0.436552822113788 0.338952155505972 no 1144 0.331217841740298 1549 659771 SGTC_1246 0422-0085 105 µM 0.435810331752571 0.33921186355823 no 1145 0.331487173560893 1662 264295 SGTC_1174 0739-0097 51.1 µM 0.435301084717635 0.339390032014089 no 1146 0.331671948825963 1582 728447 SGTC_149 3970-0822 46.1 µM 0.433468812431471 0.340031379417368 no 1147 0.332337109331699 1601 3114250 YBL034C STU1 SGTC_869 0564-0080 44.1 µM 0.433312404286429 0.340086148198712 no 1148 0.332393913894942 1534 6843321 SGTC_2415 st077333 57.7 µM 0.432255794584023 0.340456225116893 no 1149 0.33277775591352 1825 2766255 SGTC_2004 4023728 41.89 µM 0.431978631926576 0.340553326630224 no 1150 0.332878471781699 1672 360084 YDR527W RBA50 SGTC_1178 0988-0033 191 µM 0.431946420903544 0.340564612166131 no 1151 0.332890177463861 1617 5392207 SGTC_1833 st055984 71 µM 0.431942641431616 0.34056593636088 no 1152 0.33289155095768 1583 676288 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.431579040768638 0.340693338500423 no 1153 0.333023697164366 1645 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1851 st056236 18.9 µM 0.431127178879664 0.340851691844198 no 1154 0.33318794973122 1689 5393171 SGTC_784 4579-0127 173 µM 0.429422192277443 0.341449450517695 no 1155 0.333808003220483 1719 1948547 SGTC_672 1441-0018 53.7 µM 0.429169518257928 0.341538070494713 no 1156 0.333899932005048 1539 251141 SGTC_1879 gemcitabine 100 µM 0.423840717570414 0.34340906098004 no 1157 0.335840990406727 1608 60750 A nucleoside analog which inhibits DNA replication. SGTC_1169 aniline yellow 25.8 µM 0.422922893503948 0.343731706689052 no 1158 0.336175759521601 1660 6051 A DNA damaging agent. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.422913207310147 0.343735112316115 no 1159 0.336179293178135 1673 1377 SGTC_1283 0922-0125 16.4 µM 0.422360384245623 0.34392950370646 no 1160 0.336380994605264 1690 3360884 SGTC_2428 5615643 7.78 µM 0.422150470632862 0.344003327282664 no 1161 0.336457595420585 1634 2253075 SGTC_1002 4049-0206 172 µM 0.422139157379158 0.344007306158985 no 1162 0.336461723999574 1555 4662749 SGTC_1430 4049-0248 69.1 µM 0.421613877348244 0.344192066390655 no 1163 0.33665343769165 1691 22774488 SGTC_223 busulfan 5 mM 0.421157827597526 0.344352505964837 no 1164 0.336819918551566 1640 2478 A DNA alkylator. SGTC_1409 3909-8004 61.9 µM 0.42006038234002 0.344738705033898 no 1165 0.337220671713035 1615 2119279 SGTC_2833 9001315 45.46 µM 0.419779520024524 0.344837568578721 no 1166 0.337323263681561 1615 2989378 SGTC_473 2-arachidonoylglycerol 10 µM 0.419003266675436 0.345110864876765 no 1167 0.337606872481443 1571 5282280 An endocannabinoid. SGTC_164 4100-3994 89.624 µM 0.418578081132891 0.345260594640676 no 1168 0.337762255676265 1729 4615967 SGTC_3226 9131256 49.47 µM 0.418168528426189 0.345404842181141 no 1169 0.337911952033126 1540 17178073 SGTC_65 0798-0905 34.986 µM 0.415806400633106 0.34623723903214 no 1170 0.338775837415747 1790 3602145 SGTC_968 1309-0633 340 µM 0.414646255936205 0.346646338142518 no 1171 0.33920044057236 1679 3761976 SGTC_1273 0849-0096 14.1 µM 0.414581749443526 0.34666909017055 no 1172 0.339224055403705 1582 5286025 SGTC_1404 3909-7820 48.3 µM 0.414570646492939 0.34667300633823 no 1173 0.339228120086255 1691 23741373 SGTC_1071 trifluoperazine 6.31 µM 0.414108836971043 0.346835907595813 no 1174 0.339397200642317 1699 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1812 st052057 4.327 µM 0.412721427279959 0.347325480427595 no 1175 0.339905362045826 1568 3645418 SGTC_1445 4239-0156 97.7 µM 0.410669071244861 0.348050158858811 no 1176 0.340657604383459 1746 4008346 SGTC_3115 9123671 49.47 µM 0.409729062578203 0.348382257602729 no 1177 0.341002354168791 1674 3286988 SGTC_2910 7948405 25.97 µM 0.409704827446892 0.348390821250196 no 1178 0.341011244201837 1713 2971328 SGTC_314 1671-0008 2.74 µM 0.407411802849703 0.349201426017048 no 1179 0.341852779825046 1594 3913060 SGTC_936 3005-4620 401 µM 0.406581288278397 0.349495190395221 no 1180 0.34215777129928 1725 777207 SGTC_1132 3456-3614 2.5 µM 0.406275641750536 0.349603324464107 no 1181 0.34227004040416 1822 3125502 SGTC_2826 7992541 19.48 µM 0.405839475561917 0.34975765595305 no 1182 0.342430275714906 1657 2985066 SGTC_539 4859-0462 2.54 µM 0.405730633586971 0.349796172081435 no 1183 0.342470265648819 1742 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1771 st048882 4.1505 µM 0.40534880406399 0.3499313030834 no 1184 0.342610568662063 1545 4580403 SGTC_1828 st055811 49 µM 0.404891607409209 0.350093131822381 no 1185 0.342778593847942 1720 5877589 SGTC_2300 7976697 71.57 µM 0.401089940397285 0.351439816983962 no 1186 0.344176953452159 1558 2236109 SGTC_3096 9117468 49.47 µM 0.39787480086983 0.352580191412893 no 1187 0.345361237932595 1609 41316311 SGTC_1240 0356-0016 42.1 µM 0.397541758350138 0.352698393884832 no 1188 0.345483999708197 1661 4305613 SGTC_252 miconazole 1.30953 nM 0.396113503048934 0.353205467210555 no 1189 0.346010648670136 1651 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2838 9002687 71.43 µM 0.394670485740827 0.353718046302461 no 1190 0.346543043583447 1573 6457060 SGTC_368 fentichlor 4.58 µM 0.39331673597705 0.35419915760771 no 1191 0.347042779375771 1596 7329 A pesticide. SGTC_1935 st074532 41.6 µM 0.392391357997027 0.35452816319439 no 1192 0.34738453521667 1787 2829742 SGTC_2391 6285546 200 µM 0.392090033358387 0.354635318525599 no 1193 0.347495845683912 1601 846083 SGTC_207 4185-0010 4.486 µM 0.390842396588452 0.355079118269634 no 1194 0.347956867317758 1661 3761753 SGTC_1993 st073995 70.8 µM 0.390701936062964 0.355129094134266 no 1195 0.348008783810298 1648 3098394 SGTC_2236 dapsone 200 µM 0.386227655495764 0.356722343366082 no 1196 0.349664036833832 1684 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2710 st078562 53.7235 µM 0.385538983089834 0.35696779609674 no 1197 0.349919065046455 1581 17250908 SGTC_2727 riluzole 51.77 µM 0.385429099696802 0.35700696559609 no 1198 0.349959763180037 1657 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1986 st071812 45 µM 0.384394804031485 0.357375728821932 no 1199 0.350342925526672 1639 11838594 SGTC_3205 9113483 49.47 µM 0.382842596739232 0.35792939589284 no 1200 0.350918237803756 1759 17018033 SGTC_3084 9116877 49.47 µM 0.380455639549016 0.358781398509753 no 1201 0.351803609834952 1747 27241325 SGTC_1689 st020265 53.493 µM 0.380433669229564 0.358789243887256 no 1202 0.351811762825724 1750 5758320 YPR016C TIF6 SGTC_2348 9022543 33.42 µM 0.379386153138992 0.359163370305674 no 1203 0.352200565779599 1690 3162678 YDL140C RPO21 SGTC_656 4090-1979 187 µM 0.378838721239341 0.359358942542096 no 1204 0.352403815709969 1787 22330961 SGTC_2316 5844804 197.44 µM 0.378498487251923 0.359480511067977 no 1205 0.352530158666419 1797 776813 SGTC_220 paclitaxel 373.376 µM 0.37847136830898 0.359490201511411 no 1206 0.352540229752275 1695 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1001 4048-4355 44.4 µM 0.377597279724167 0.359802588964417 no 1207 0.352864892904642 1616 21824233 SGTC_2970 9090938 41.86 µM 0.377534815098122 0.359824916566944 no 1208 0.352888098277019 1812 17217104 SGTC_1741 st038134 10.228 µM 0.377149206177307 0.359962760730848 no 1209 0.353031362646682 1776 1272587 SGTC_2856 9022925 19.48 µM 0.376737245312205 0.36011004508439 no 1210 0.353184440512712 1671 4944862 SGTC_2721 ifenprodil 61.44 µM 0.376502875677727 0.360193846245816 no 1211 0.353271539010211 1744 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2026 5148700 152 µM 0.375585969108037 0.360521759703205 no 1212 0.353612361680333 1653 79838 SGTC_913 3487-1245 167 µM 0.375376600114674 0.360596650770704 no 1213 0.353690202547752 1565 4016153 SGTC_2386 9075165 157.42 µM 0.372410721751741 0.361658115490341 no 1214 0.3547935361551 1685 16452277 SGTC_1636 st007707 68.9 µM 0.370774627154652 0.362244117502969 no 1215 0.355402700535889 1785 403051 SGTC_1107 amlodipine 47 µM 0.370025578004923 0.362512513228712 no 1216 0.355681716201798 1622 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3231 9132313 49.47 µM 0.368561769165259 0.363037213225932 no 1217 0.356227198084811 1695 4905967 SGTC_3222 9128301 49.47 µM 0.367676654473469 0.363354606047819 no 1218 0.356557175031458 1654 4911358 SGTC_2709 st078560 56 µM 0.366388165634159 0.36381681227908 no 1219 0.357037724598453 1794 17250903 SGTC_3090 9117696 49.47 µM 0.365010288039719 0.364311303350558 no 1220 0.357551863289103 1781 7923821 SGTC_1583 clindamycin 39.6 µM 0.364966844259904 0.364326898080964 no 1221 0.357568078031034 1603 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1164 k060-0068 93.7 µM 0.364507853998067 0.364491672539961 no 1222 0.357739404992473 1681 5963676 SGTC_977 1348-1378 135 µM 0.362551191684766 0.365194381915816 no 1223 0.35847008810753 1653 X977 SGTC_152 4469-0003 551.229 µM 0.359072224673721 0.36644492408502 no 1224 0.359770529705566 1759 697280 SGTC_3350 9150499 3.57 µM 0.358666745058985 0.366590769544375 no 1225 0.359922204452843 1675 4910996 YPR165W RHO1 SGTC_96 0929-0093 37.281 µM 0.358523913721329 0.366642148608202 no 1226 0.359975637565347 1649 6991579 SGTC_2662 daunorubicin 22.37 µM 0.358106164346918 0.366792434467954 no 1227 0.360131933041994 1678 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2241 6772625 37.8075 µM 0.3561706859005 0.367488991407969 no 1228 0.360856371806609 1633 2285411 SGTC_3238 9133470 49.47 µM 0.355709733610576 0.367654947355389 no 1229 0.361028977417758 1791 3534688 SGTC_1068 loratadine 26.9 µM 0.354517041419675 0.368084465137526 no 1230 0.361475717534914 1669 3957 A H1 histamine antagonist. SGTC_1328 1441-0025 69.2 µM 0.3543056304743 0.368160616643752 no 1231 0.361554924292276 1594 4562601 SGTC_2947 9072639 7.68 µM 0.353695446906982 0.368380437514434 no 1232 0.361783567582491 1629 16488146 SGTC_950 1165-0508 94.1 µM 0.353002804289986 0.368630016775105 no 1233 0.36204316909445 1644 6148369 SGTC_861 0443-0273 110 µM 0.352947876717123 0.368649811148853 no 1234 0.362063758592277 1752 6149169 SGTC_832 4083-0019 164 µM 0.35227834562003 0.36889111958613 no 1235 0.362314763140566 1822 1990758 SGTC_2644 guaiazulene 100 µM 0.35185491497399 0.369043756644639 no 1236 0.362473536177386 1770 3515 A coloring agent. SGTC_2387 9077560 195.08 µM 0.350987083931557 0.369356654396145 no 1237 0.362799019141927 1651 5303272 SGTC_1789 tunicamycin 25 nM 0.348502364734427 0.370253001617421 no 1238 0.363731469101967 1803 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_641 4092-0595 30 µM 0.347914598236264 0.370465138075507 no 1239 0.363952160787175 1762 786260 SGTC_2922 7999257 32.47 µM 0.34741815545527 0.370644344706226 no 1240 0.364138597853301 1673 2988377 SGTC_342 k048-0088 23.3 µM 0.345708968323976 0.371261543999054 no 1241 0.364780721822275 1660 6820570 SGTC_2473 5854593 8.94 µM 0.34556494418304 0.371313567265419 no 1242 0.364834847566924 1687 2872951 SGTC_2203 7227154 166.4 µM 0.345011055621632 0.371513660431943 no 1243 0.365043029644119 1722 896304 SGTC_62 0180-0423 3.232 µM 0.343834872728436 0.371938673562339 no 1244 0.365485236363945 1774 30102 YGL099W LSG1 SGTC_1051 3253-3903 78 µM 0.342597836015779 0.37238584461037 no 1245 0.365950515132548 1675 5509239 SGTC_2685 mycophenolic acid 18.85 µM 0.342310797408669 0.372489629576972 no 1246 0.366058505357195 1778 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3041 9091929 49.47 µM 0.341716646983118 0.372704486824043 no 1247 0.366282071495184 1760 25236887 SGTC_2532 xanthone 78.9 µM 0.341216034229262 0.372885549640943 no 1248 0.36647047664241 1786 7020 An insecticide. SGTC_3157 9099274 49.47 µM 0.340433096593417 0.373168780692159 no 1249 0.366765199013169 1846 17217662 SGTC_782 0083-0095 30.5 µM 0.340355237894244 0.373196950160835 no 1250 0.366794511775827 1703 3591729 An indicator and reagent. SGTC_901 1112-0062 60.1 µM 0.340232381522192 0.373241401276674 no 1251 0.366840767142526 1715 1908457 SGTC_837 0091-0265 12.5 µM 0.340155589511056 0.373269186533544 no 1252 0.366869680280869 1698 759367 SGTC_776 4476-4378 112 µM 0.339712517200456 0.373429513966229 no 1253 0.367036517210372 1703 2892008 SGTC_446 go6976 132 µM 0.338563293642795 0.373845467029774 no 1254 0.367469369260815 1836 3501 A protein kinase C inhibitor. SGTC_755 1995-0008 37.3 µM 0.338096034469841 0.374014630122856 no 1255 0.367645409404101 1708 689533 SGTC_1026 k007-1105 30.6 µM 0.337318644556423 0.374296124435884 no 1256 0.367938353081864 1719 7066794 SGTC_15 0266-0086 27.098 µM 0.335849888737875 0.37482814645118 no 1257 0.368492033602175 1815 1712902 YIL048W NEO1 SGTC_1917 st066507 28.5 µM 0.335399501506372 0.374991336350013 no 1258 0.368661871971905 1693 3156428 SGTC_227 fluconazole 33.516 µM 0.331655794223236 0.376348666605919 no 1259 0.370074592043039 1695 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_857 0438-0306 1.35 µM 0.331447669249611 0.376424170112332 no 1260 0.370153181450387 1743 4686136 SGTC_2455 5377712 9.75 µM 0.331225044372528 0.376504939122935 no 1261 0.370237252121152 1645 2243908 SGTC_2606 farnesol 9.78 µM 0.331197324226551 0.376514996458324 no 1262 0.370247720618375 1827 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2755 lomerizine 42.69 µM 0.330145852424815 0.376896549957635 no 1263 0.370644879240845 1678 3949 A calcium channel blocker. SGTC_2263 7948595 193.29 µM 0.329948213467634 0.376968281757577 no 1264 0.37071954621348 1708 2971371 SGTC_24 0417-1663 219 µM 0.329570933785335 0.377105224802648 no 1265 0.370862094037217 1734 4329390 SGTC_2220 6782180 200 µM 0.328214505670229 0.377597701712566 no 1266 0.371374740435628 1832 833803 SGTC_1344 1488-0097 29.1 µM 0.328143668156291 0.377623426089424 no 1267 0.371401518938348 1769 747966 SGTC_1126 isoteolin 1.0172 µM 0.327722998631668 0.377776201825665 no 1268 0.371560556255368 1649 133323 SGTC_2813 7971799 71.43 µM 0.327189124639615 0.377970117876389 no 1269 0.371762422951864 1754 2234054 SGTC_144 4161-2749 112.381 µM 0.326769827048056 0.378122438547422 no 1270 0.371920991119668 1778 797501 YMR168C CEP3 SGTC_3148 9097893 49.47 µM 0.324912026715073 0.378797560106491 no 1271 0.372623827158289 1600 17174100 SGTC_1183 1254-0324 198 µM 0.32474447581864 0.378858466043691 no 1272 0.372687235278593 1825 5799357 SGTC_3029 9088683 49.47 µM 0.323431381172231 0.37933588930417 no 1273 0.373184283410154 1764 25236615 SGTC_771 0250-0039 27.3 µM 0.32286183453066 0.379543025955096 no 1274 0.373399940644299 1754 3005115 SGTC_2614 arthonioic acid 13.39 µM 0.322735568296378 0.379588952014528 no 1275 0.37344775637185 1683 6710684 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.321413475917008 0.380069930643487 no 1276 0.373948536079496 1716 279621 SGTC_2515 chrysin 20.77 µM 0.319515241160491 0.380760834776511 no 1277 0.374667917919226 1833 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2499 avocadenofuran 51.48 µM 0.316861234025837 0.381727456184884 no 1278 0.375674449104926 1667 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2089 5281248 129.67 µM 0.315193591540337 0.382335209630716 no 1279 0.37630733549178 1713 2737878 SGTC_1613 st002381 52.1 µM 0.31432181628637 0.382653033777372 no 1280 0.376638315139618 1798 551167 SGTC_2479 5617353 43.85 µM 0.313148375229424 0.383080961362383 no 1281 0.37708396890758 1818 2731746 SGTC_2960 9079389 5.97 µM 0.313064641914468 0.38311150248242 no 1282 0.377115775721788 1890 16457355 SGTC_1294 1000-1494 117 µM 0.312780727639538 0.383215063564919 no 1283 0.377223629187212 1708 712797 YDL207W GLE1 SGTC_138 0850-0259 40.9225 µM 0.311582855129188 0.383652093514052 no 1284 0.377678782826933 1770 6813004 SGTC_497 capsazepine 133 µM 0.311414395646512 0.383713565897181 no 1285 0.377742805739676 1670 2733484 A calcium channel blocker. SGTC_1187 1391-0724 117 µM 0.311326091598926 0.383745790009047 no 1286 0.37777636697525 1783 6997986 SGTC_1840 st055363 71 µM 0.310235989207144 0.384143658785361 no 1287 0.378190752144889 1686 676033 SGTC_1061 3448-9325 110 µM 0.308870470895694 0.38464222193342 no 1288 0.378710030020829 1863 723482 SGTC_1824 st053723 68.6 µM 0.308087202839522 0.384928286406474 no 1289 0.379007989299889 1709 675225 SGTC_1937 st074714 47.2 µM 0.307339956669396 0.385201253393948 no 1290 0.379292312692871 1669 17250970 SGTC_3305 9127027 53.8275 µM 0.306186038372533 0.385622888315738 no 1291 0.379731501011463 1783 41905295 SGTC_2903 5923464 63.88 µM 0.306052959484279 0.385671523258603 no 1292 0.379782161636859 1887 2876576 SGTC_1829 berberine 14.4 µM 0.305041946536789 0.38604106618449 no 1293 0.38016710254252 1888 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1514 1189-1591 158 µM 0.303316792936332 0.386671878661373 no 1294 0.380824224861377 1847 767698 YMR146C TIF34 SGTC_3271 9137798 49.47 µM 0.303131454017547 0.386739666766991 no 1295 0.380894842162539 1890 6498326 SGTC_939 1165-0479 45.3 µM 0.302446660418159 0.386990161446588 no 1296 0.381155794642219 1904 1377347 SGTC_3340 9146634 11.102 µM 0.301309806298558 0.387406121909067 no 1297 0.381589131924017 1757 4907387 SGTC_1013 4112-3890 241 µM 0.299802138999626 0.38795795756133 no 1298 0.382164041824938 1743 705171 SGTC_1637 st007924 17.4 µM 0.298304029507448 0.388506519076747 no 1299 0.382735564558778 1756 683336 SGTC_891 0929-0073 133 µM 0.298272657932566 0.388518008762018 no 1300 0.382747535423086 1854 5603632 SGTC_1025 k007-0731 70 µM 0.298185363045777 0.388549980599012 no 1301 0.382780846270287 1741 6256118 SGTC_365 0121-0052 13.6 µM 0.297694782601178 0.388729670201835 no 1302 0.382968062935755 1824 3101739 SGTC_940 3232-1287 54.8 µM 0.294961268270453 0.389731335640189 no 1303 0.384011733737186 1935 1585493 YIL048W NEO1 SGTC_249 wiskostatin 11.211 µM 0.294948148545671 0.389736144987468 no 1304 0.384016744955856 1880 2775510 A n-wasp and actin depolymerizer. SGTC_1476 4112-3294 3.34 µM 0.29239477617422 0.390672464916581 no 1305 0.384992400909442 1874 704369 SGTC_2612 dictamnine 15.46 µM 0.292211572514082 0.390739670026703 no 1306 0.385062432002055 1801 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2934 9036370 36.88 µM 0.291969374458922 0.390828521224583 no 1307 0.385155019937223 1903 6462800 SGTC_2050 5263056 171 µM 0.29116952659671 0.39112198866029 no 1308 0.385460833794563 1918 763468 YGL055W OLE1 SGTC_1342 1486-1464 234 µM 0.291163032815451 0.391124371509019 no 1309 0.385463316918837 1782 3253938 SGTC_1147 3809-1045 12.3 µM 0.289735594867419 0.391648259161946 no 1310 0.386009261493349 1783 325925 SGTC_2452 5863136 48.41 µM 0.28889414657301 0.391957173403055 no 1311 0.386331191599308 1771 2184096 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.288017817837577 0.392278965438318 no 1312 0.386666549828019 1872 5282309 SGTC_1945 st075991 56.6 µM 0.287803331170225 0.392357737183404 no 1313 0.386748643652582 1747 1084980 SGTC_86 0417-1630 471.922 µM 0.284792319110362 0.39346401681736 no 1314 0.387901628561218 1909 3634867 SGTC_189 3970-0742 2.116 µM 0.282146760342696 0.394436735468243 no 1315 0.388915489754904 1921 2891807 SGTC_320 4092-0846 5.34 µM 0.281087622910289 0.394826343928756 no 1316 0.389321597056886 1884 1359356 SGTC_1220 1838-0075 193 µM 0.280210295986128 0.395149152260068 no 1317 0.389658083956324 1851 5529645 SGTC_677 0929-0063 136 µM 0.278825617725836 0.395658784501832 no 1318 0.390189326846867 1796 1539583 SGTC_640 3381-0960 37.1 µM 0.277532460081068 0.396134893664279 no 1319 0.390685642393272 1887 1745025 SGTC_1350 1495-0454 146 µM 0.276355978814301 0.396568180074584 no 1320 0.391137332187558 1909 1069057 SGTC_2976 9009005 19.48 µM 0.275360549667411 0.396934886583026 no 1321 0.391519624864501 1971 2993148 SGTC_617 3770-0098 35 µM 0.273488074968582 0.397624934985723 no 1322 0.392239028930688 1829 5962639 SGTC_3139 9095020 49.47 µM 0.273328107852907 0.39768390129958 no 1323 0.392300505354008 1841 25236292 SGTC_3297 9117502 71.43 µM 0.269589621718986 0.399062627194193 no 1324 0.393737992745024 1887 7453720 SGTC_441 propafenone 146 µM 0.2678627347988 0.399699916816337 no 1325 0.39440248955033 1826 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1309 pyrazolanthrone 13.4 µM 0.266282740502725 0.400283231456429 no 1326 0.395010732239739 1931 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1926 methyl fluorone black 53.6 µM 0.265922732735545 0.400416173109641 no 1327 0.395149358527517 1855 72721 Reacts with homocysteine. SGTC_1734 st037168 69.4 µM 0.265449547284084 0.400590925931504 no 1328 0.395331585731538 1784 708907 SGTC_986 1493-0483 84 µM 0.26368535057959 0.4012426391719 no 1329 0.39601119234388 1956 40079 SGTC_1163 k060-0048 49.9 µM 0.263379138949236 0.401355785086803 no 1330 0.396129183928662 1817 6809982 SGTC_1657 st012939 43.4 µM 0.262462138068658 0.401694668502765 no 1331 0.39648258593448 1943 24207257 SGTC_201 4262-0159 12.803 µM 0.262391440032131 0.401720798477887 no 1332 0.39650983571202 1956 1341029 SGTC_2122 5258151 111.688 µM 0.262320014726734 0.401747197697573 no 1333 0.396537366320645 1823 2173356 SGTC_582 0987-0078 156 µM 0.262260709598907 0.401769117567896 no 1334 0.396560225645512 1925 1625765 SGTC_1098 clofazimine 15.1 µM 0.261659766459022 0.401991250615876 no 1335 0.396791880875914 1922 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1182 1222-0449 220 µM 0.260731680490574 0.402334371155854 no 1336 0.397149716667082 1869 658318 SGTC_750 4073-0104 132 µM 0.260327275611584 0.402483906317017 no 1337 0.397305667410147 1909 22330957 SGTC_2286 7945697 125 µM 0.259672599288154 0.402726013580785 no 1338 0.3975581651802 1775 1245733 SGTC_2438 5259590 200 µM 0.258892981907545 0.403014374226863 no 1339 0.397858906629162 1947 1201127 SGTC_1038 k292-0204 154 µM 0.257163836690936 0.403654129126309 no 1340 0.398526149758633 1795 4454212 SGTC_1721 st082152 9.2685 µM 0.254247453315719 0.404733725759747 no 1341 0.399652196146179 1851 5296051 SGTC_2063 5246145 200 µM 0.252564587162064 0.405357025527485 no 1342 0.40030234914203 1912 711240 SGTC_2197 6588183 93.1375 µM 0.252248770444956 0.40547402449094 no 1343 0.40042439159182 1901 884136 SGTC_2125 5246583 200 µM 0.250826399687914 0.406001067268192 no 1344 0.400974164948835 2022 835267 SGTC_2986 9022445 71.43 µM 0.250273576447401 0.406205955464562 no 1345 0.401187894646072 1987 6459286 SGTC_3279 9140807 49.47 µM 0.245872523330381 0.407837992334581 no 1346 0.402890457109202 1942 45595718 SGTC_3213 9129884 49.47 µM 0.245397517476274 0.408014234341438 no 1347 0.403074325512953 1771 17190742 SGTC_906 1165-0455 526 µM 0.24411308305179 0.40849089274366 no 1348 0.403571620103254 1831 3252859 SGTC_3159 9100096 49.47 µM 0.243838781530592 0.408592704631414 no 1349 0.403677841682201 1897 25236875 SGTC_1860 st056228 74.6 µM 0.243820018278494 0.408599669171628 no 1350 0.403685107896015 1835 688679 SGTC_407 eburnamonine 100 µM 0.243788441918449 0.408611389743885 no 1351 0.403697336159558 1843 3195 SGTC_1047 2043-3044 82 µM 0.243451933585294 0.40873630061011 no 1352 0.403827658246403 1828 669592 SGTC_1786 berberine 21.6 µM 0.243447134894197 0.408738081936674 no 1353 0.403829516748467 1815 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2028 5153890 36.43 µM 0.242946230366088 0.408924033532498 no 1354 0.404023525770635 1865 2830968 YPR165W RHO1 SGTC_1337 1486-1011 40.3 µM 0.242130202842066 0.409227012632191 no 1355 0.404339637944835 2000 X1337 SGTC_1224 0823-0416 294 µM 0.241968509915669 0.409287053297332 no 1356 0.40440228185927 1954 3598164 SGTC_2999 9069765 71.4286 µM 0.238800951952004 0.410463675004317 no 1357 0.405629966016887 1931 2097066 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.238671993858293 0.410511594956887 no 1358 0.405679967437187 1984 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_548 1436-0017 110 µM 0.237971497828606 0.410771917848655 no 1359 0.405951600336048 1983 9677137 SGTC_1118 chelidonine 707.474 nM 0.235818121463935 0.411572415254709 no 1360 0.406786902891026 2034 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3013 9080133 71.4286 µM 0.234889827642393 0.41191761352853 no 1361 0.407147122541978 1926 17050193 SGTC_1343 1487-0095 224 µM 0.234678357728862 0.411996260942448 no 1362 0.40722919335233 2010 4560101 YGL055W OLE1 SGTC_159 3970-0959 50 µM 0.234199335972448 0.412174426172699 no 1363 0.407415115251421 1968 6615653 SGTC_295 k015-0027 31 µM 0.230244094881423 0.413646209566291 no 1364 0.408951049682108 1940 3887424 SGTC_2654 protoveratrine a 100 µM 0.228971941757494 0.41411984905189 no 1365 0.409445362029219 1934 5702278 A heart drug and vasodilator. SGTC_1386 3228-0095 33.8 µM 0.227059685373191 0.414832042316751 no 1366 0.410188665866021 1986 870181 SGTC_2310 7668677 200 µM 0.225457309194303 0.415429040750722 no 1367 0.41081176637091 1938 2197143 SGTC_2850 9015429 58.44 µM 0.224620499390738 0.415740889284806 no 1368 0.411137258081184 1879 6457570 SGTC_720 r052-1644 49.9 µM 0.22267991227774 0.416464279339105 no 1369 0.411892318259376 1906 1422863 YOR257W CDC31 SGTC_2224 6650123 117.647 µM 0.221601522129463 0.416866391883422 no 1370 0.412312048733173 1917 2908370 SGTC_938 3126-1755 342 µM 0.221179074330481 0.417023938906366 no 1371 0.412476501025864 2042 1777771 SGTC_1627 st003713 25.6 µM 0.221135726163426 0.417040105858402 no 1372 0.412493376656191 1878 16195070 YER133W GLC7 SGTC_1365 1672-3266 55.4 µM 0.220289352618471 0.417355793890738 no 1373 0.412822905942329 2026 6415873 SGTC_1196 1588-0294 184 µM 0.220217667549565 0.41738253408404 no 1374 0.412850818819904 1884 6144269 SGTC_3126 9127922 49.47 µM 0.219322923868199 0.417716326338655 no 1375 0.413199252960023 1947 45595682 SGTC_1257 0669-0121 16 µM 0.218567725227965 0.417998106201681 no 1376 0.413493398221182 1997 4307855 SGTC_2191 5911152 200 µM 0.218337545734829 0.418083999196783 no 1377 0.413583061391481 1928 2875902 SGTC_2700 st077718 96.8 µM 0.21628269603412 0.41885095256855 no 1378 0.414383698215289 1868 904970 SGTC_2119 5528445 120.635 µM 0.216017445302284 0.4189499774603 no 1379 0.41448707460266 2018 791935 SGTC_2985 9022375 71.43 µM 0.215650498755071 0.419086976469018 no 1380 0.414630094748341 1934 4939335 SGTC_3043 9092303 49.47 µM 0.214071693279537 0.419676533126426 no 1381 0.415245574799546 1855 25236084 SGTC_2112 5488546 200 µM 0.213902203644833 0.419739834593079 no 1382 0.415311660872719 1939 600757 SGTC_930 2810-3379 265 µM 0.213539030486683 0.419875480518794 no 1383 0.415453274575934 2050 1015764 SGTC_962 1254-0300 21.5 µM 0.208773956449917 0.421656121521085 no 1384 0.417312351533433 1930 7340576 SGTC_2993 9054257 71.4286 µM 0.20791258046917 0.421978177734616 no 1385 0.417648613011795 1974 6470217 YGL055W OLE1 SGTC_488 nitrendipine 139 µM 0.205461958832574 0.422894714986962 no 1386 0.418605608248493 2005 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3059 1327-0034 3 µM 0.203966430593167 0.423454250922645 no 1387 0.419189865968907 1909 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1192 1488-0095 21.4 µM 0.202704762448738 0.423926410719183 no 1388 0.419682900280556 1951 915875 SGTC_2142 5622915 118.518 µM 0.202280040717046 0.42408538086813 no 1389 0.419848901324767 1925 5322196 SGTC_2421 5690543 90.72 µM 0.202254544337425 0.424094924364503 no 1390 0.419858866952091 1942 3397993 SGTC_759 3486-0358 89.3 µM 0.200960522801452 0.424579345189918 no 1391 0.420364721270187 2083 875103 SGTC_2053 5265679 138 µM 0.200276466030178 0.424835469966939 no 1392 0.42063218352986 1949 764595 SGTC_1772 st048439 82.2 µM 0.200236668847397 0.424850371820003 no 1393 0.420647745128374 1927 2927068 YDL195W SEC31 SGTC_3129 9127257 49.47 µM 0.199991570488791 0.424942150022777 no 1394 0.420743586862448 1808 837894 SGTC_190 3970-0790 3.722 µM 0.199463708673341 0.425139824107258 no 1395 0.420950014603094 2049 2832352 SGTC_1612 st002233 45.4 µM 0.198690226472672 0.425429512280347 no 1396 0.421252534872545 2060 1035021 SGTC_1864 st057645 30.4 µM 0.195997813685838 0.42643820032705 no 1397 0.422305938618117 2091 688666 SGTC_2561 acetosyringone 100 µM 0.195114371409884 0.42676927917683 no 1398 0.422651706018868 2102 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2460 5552655 174.22 µM 0.194256706111812 0.427090747213192 no 1399 0.422987441682749 1923 5401989 SGTC_666 0272-0154 136 µM 0.194088579957668 0.427153769535771 no 1400 0.423053261737354 1978 6870312 SGTC_2013 4024628 200 µM 0.191149487490806 0.428255791388413 no 1401 0.42420423847975 1998 5230760 SGTC_1479 0549-0158 134 µM 0.190407216987857 0.428534196892077 no 1402 0.424495021394337 1955 5440202 SGTC_2992 9074591 71.4286 µM 0.190313254060647 0.428569442372941 no 1403 0.424531834108163 2074 17741321 SGTC_633 0437-0093 97.7 µM 0.188934488644326 0.429086682456431 no 1404 0.425072081158749 1976 2831118 SGTC_1151 3909-8316 15.3 µM 0.188404290039766 0.429285617487141 no 1405 0.425279868477005 1969 800431 SGTC_53 0973-0023 39.979 µM 0.187586274501901 0.429592579097365 no 1406 0.425600493298181 2129 674768 SGTC_2868 9035608 32.47 µM 0.187543749515269 0.429608537830809 no 1407 0.425617162502658 2005 6462614 SGTC_124 0136-0217 7.121 µM 0.18731840359562 0.42969310733603 no 1408 0.425705497193284 2139 3976905 SGTC_3108 9121785 49.47 µM 0.185932032479591 0.430213465913933 no 1409 0.426249030946402 2095 17140271 SGTC_2556 citropten 84.59 µM 0.185913733899792 0.430220334889596 no 1410 0.426256205935612 1962 2775 A potential DNA crosslinker. SGTC_1518 st038567 90.8 µM 0.184940653233445 0.430585643192342 no 1411 0.426637792141248 2073 77966 SGTC_1368 1852-0141 284 µM 0.184334396654242 0.430813270580398 no 1412 0.426875565807408 1981 2838987 SGTC_3034 9090421 49.47 µM 0.183935480662014 0.430963061631236 no 1413 0.427032035052158 2084 17173761 SGTC_2358 9037157 4 µM 0.183276905412086 0.431210375216078 no 1414 0.427290377138231 1985 2388925 SGTC_57 miconazole 162.5 nM 0.182938513984321 0.431337461239748 no 1415 0.427423131503273 1961 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_51 1013-0126 23.419 µM 0.18102991454153 0.432054386115623 no 1416 0.42817204775885 2140 1627850 SGTC_2462 5162487 171.77 µM 0.179860232248987 0.432493863209073 no 1417 0.428631148031654 2106 2259986 SGTC_2738 aclarubicin 5.55 µM 0.178646283630762 0.432950060524998 no 1418 0.429107724976125 2050 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2749 bexarotene 57.39 µM 0.177117573199058 0.433524671212511 no 1419 0.429708019366892 1953 82146 An retinoic acid receptor inhibitor. SGTC_391 gliotoxin 8.33 µM 0.175590573803246 0.434098779062984 no 1420 0.430307804153922 2022 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1449 4112-4002 201 µM 0.174473088626817 0.4345190095205 no 1421 0.430746839272593 1919 2059539 SGTC_1830 st055982 50.3 µM 0.17444631519792 0.434529078581728 no 1422 0.430757359010672 2128 455313 An antimicrobial agent. SGTC_1459 k035-0031 35.7 µM 0.174260038191732 0.434599135579457 no 1423 0.430830551791732 1902 3877128 YMR208W ERG12 SGTC_911 3456-4043 236 µM 0.174150459039823 0.434640348208372 no 1424 0.430873609224427 2042 914281 SGTC_2378 9074213 121.43 µM 0.173947188330076 0.434716800035509 no 1425 0.430953483480964 2092 657714 SGTC_1398 3558-0053 112 µM 0.172871174998233 0.435121538314167 no 1426 0.431376344759568 1986 4532369 SGTC_1873 rapamycin 2 nM 0.172852027963523 0.435128741014564 no 1427 0.43138387004513 1976 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1202 1988-0068 29.6 µM 0.172658522120151 0.435201534935843 no 1428 0.431459924301339 1920 2850480 SGTC_746 1095-0025 46.6 µM 0.172209182187894 0.435370578171961 no 1429 0.431636539691376 2058 6749286 SGTC_2292 7671323 168.05 µM 0.171580568971685 0.435607084450491 no 1430 0.431883642301426 1982 937504 SGTC_1212 0520-0165 585 µM 0.171563677745153 0.435613439838849 no 1431 0.431890282469776 2123 5403258 SGTC_2066 5222451 176 µM 0.17128896258977 0.435716804796389 no 1432 0.431998279392602 2077 2281147 SGTC_2729 fluphenazine 10.66 µM 0.170807982878857 0.435897789902307 no 1433 0.432187375947217 2066 3372 An atypical antipsychotic. SGTC_853 0419-0306 21 µM 0.170756108138236 0.435917310354603 no 1434 0.432207771363663 1944 762713 SGTC_3004 9076122 71.4286 µM 0.170527331831243 0.436003400685122 no 1435 0.43229772072563 2075 44782551 SGTC_305 1682-2595 20.8 µM 0.170412937345157 0.436046449370833 no 1436 0.432342699212779 2019 226033 SGTC_1697 st025554 27.742 µM 0.169492447065006 0.436392873817194 no 1437 0.432704656391868 2025 1269519 SGTC_116 0155-0182 31.788 µM 0.16932830541889 0.436454653290451 no 1438 0.432769206466843 1963 771486 SGTC_923 1900-2434 73.3 µM 0.165142110548124 0.438030769051011 no 1439 0.434416064294665 2018 5910570 SGTC_2900 5328528 85.29 µM 0.164736098192521 0.438183686724087 no 1440 0.434575851441568 2057 795359 SGTC_2904 7225135 42.03 µM 0.164020494846137 0.4384532290551 no 1441 0.434857504876724 2130 4446116 SGTC_304 1310-0298 97 µM 0.163005114493764 0.438835735691268 no 1442 0.4352572038748 2013 1550234 SGTC_2476 5806916 10.51 µM 0.158218119304995 0.440639821115955 no 1443 0.437142463222131 2057 2870194 SGTC_2118 5526350 200 µM 0.158063978427022 0.440697933215701 no 1444 0.437203192392355 2041 743594 SGTC_1802 st050112 57.9 µM 0.157580489549516 0.440880219903816 no 1445 0.437393689276651 2124 4662563 SGTC_1258 0671-0043 57.1 µM 0.157533451158526 0.440897955153782 no 1446 0.437412223398641 1986 4298767 SGTC_2464 5717415 7.67 µM 0.156615974049307 0.441243902336705 no 1447 0.437773756220302 1956 5285744 SGTC_467 ro 31-8220 72.8 µM 0.156429899393735 0.441314069785566 no 1448 0.43784708548082 2127 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_542 3381-0244 89.3 µM 0.156066760337972 0.441451012282496 no 1449 0.437990199339183 2141 1112843 SGTC_2321 7390090 138.78 µM 0.154323919149852 0.442108348063779 no 1450 0.438677169236593 1956 649046 SGTC_44 0929-0055 61.211 µM 0.154244217256353 0.442138412521231 no 1451 0.438708589500214 2035 1379590 SGTC_664 1222-0054 14.9 µM 0.15416795013352 0.442167181656313 no 1452 0.438738656062311 2077 6813991 SGTC_694 1315-0438 43.2 µM 0.153830182259511 0.442294596572901 no 1453 0.438871817539 2069 6793154 SGTC_2802 7925815 54.55 µM 0.153189171839049 0.442536418949608 no 1454 0.439124548253662 2035 1262923 SGTC_1 0258-0098 57.368 µM 0.152470281620902 0.442807647092813 no 1455 0.439408014099388 2028 6790032 YDR047W HEM12 SGTC_2931 9014674 55.67 µM 0.151973073894425 0.44299525293763 no 1456 0.439604086432304 2069 2996810 SGTC_2193 5925765 200 µM 0.150899074497102 0.443400536715374 no 1457 0.440027665285763 2108 877370 SGTC_622 1348-1566 26.3 µM 0.150117061478324 0.443695673965737 no 1458 0.440336129701644 2083 7340407 SGTC_2541 muurolladie-3-one 83.07 µM 0.148518398546649 0.444299117689913 no 1459 0.440966833516081 2089 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_914 3820-6779 408 µM 0.146450660973525 0.44507981331911 no 1460 0.441782818357389 2090 2893481 SGTC_1223 0764-0573 147 µM 0.145952737823428 0.445267841280035 no 1461 0.441979349270246 2097 1609797 SGTC_1914 st062367 72.6 µM 0.145585927678054 0.445406365642379 no 1462 0.442124138849555 2036 978205 SGTC_260 nsc-65238 3.989 µM 0.145293687691175 0.445516733658734 no 1463 0.44223949916778 2125 3246252 SGTC_2907 7721985 69.9 µM 0.143226631366914 0.446297502910905 no 1464 0.443055598929293 2002 3267881 SGTC_3346 9158254 43.5805 µM 0.142650578821616 0.446515126918886 no 1465 0.443283074900523 2057 17639500 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.141309422714164 0.447021857875651 no 1466 0.443812753030844 2014 61125 An anti-inflammatory. SGTC_468 gf-109203x 121 µM 0.14122146259155 0.447055095007989 no 1467 0.443847495646958 2162 2396 A protein kinase C inhibitor. SGTC_2264 7948757 110.76 µM 0.140710452342261 0.447248195712397 no 1468 0.444049343740608 2025 2971411 SGTC_2136 5328288 199.296 µM 0.140547305925412 0.447309848164513 no 1469 0.444113789329543 2043 262395 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.140057867647518 0.447494812786603 no 1470 0.444307134571819 2034 23665772 A membrane-active detergent. SGTC_1569 carminic acid 40.6 µM 0.138344539699685 0.448142389751852 no 1471 0.444984063160803 2162 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1790 st045711 43.5 µM 0.138184282380845 0.448202968408302 no 1472 0.445047388383221 2167 585119 SGTC_425 3825-7017 13.1 µM 0.138056135984626 0.44825140972669 no 1473 0.445098026075256 2101 3397440 SGTC_2531 methyl deoxycholate 70.07 µM 0.137997826233608 0.448273451969287 no 1474 0.445121067762821 2049 16667744 Haematoxylin. SGTC_1313 1220-0047 237 µM 0.137778875311278 0.448356221186477 no 1475 0.445207590087719 2086 3528706 SGTC_1915 st067105 30.6 µM 0.136450588029528 0.448858396834792 no 1476 0.445732542073683 2150 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1604 st002052 72.4 µM 0.133838244686882 0.449846264272871 no 1477 0.446765242177227 2078 6254834 YHR062C RPP1 SGTC_3230 9131665 49.47 µM 0.133220408496524 0.450079947031867 no 1478 0.447009535530051 2109 15943720 SGTC_1717 st033143 58.0435 µM 0.132944093170645 0.450184462747727 no 1479 0.447118797535712 2157 674616 SGTC_2945 9067681 61.76 µM 0.131779442727834 0.450625027321509 no 1480 0.447579373528466 2169 16456930 SGTC_2055 5235184 200 µM 0.131593673728799 0.450695305755335 no 1481 0.447652844820971 2099 2836034 SGTC_80 0159-0065 512.242 µM 0.131387853377675 0.450773171638888 no 1482 0.447734248483076 2178 1548079 SGTC_88 0180-0332 8.668 µM 0.130445478014253 0.451129714909311 no 1483 0.448106993846199 2182 3101745 SGTC_730 1436-0052 41.2 µM 0.12938112197485 0.451532456397877 no 1484 0.448528042302457 2213 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_974 1326-0144 138 µM 0.129337172927351 0.451549087345399 no 1485 0.448545429349804 2039 5411856 SGTC_1898 st060199 18.6 µM 0.129096262725999 0.451640252717625 no 1486 0.44864073958836 2124 688866 SGTC_835 0312-0010 67.2 µM 0.12825655073527 0.451958036902456 no 1487 0.448972974270775 2102 1626196 SGTC_1338 1486-1223 76 µM 0.128168865679862 0.451991222587144 no 1488 0.449007669205267 2142 3444526 SGTC_2041 5107442 45.335 µM 0.127179865378736 0.452365547311227 no 1489 0.449399020532237 2162 793005 SGTC_2617 dihydrotanshinone i 20.83 µM 0.126701448174519 0.452546637687856 no 1490 0.449588349799902 2107 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_737 1950-0117 57.9 µM 0.125113874253539 0.453147636346896 no 1491 0.45021669976967 2205 5393513 SGTC_1948 st076329 66.6 µM 0.124486937254725 0.453385001892285 no 1492 0.450464871243819 2195 24208413 SGTC_330 1488-0319 80.1 µM 0.12420212226831 0.45349284162283 no 1493 0.450577620962287 2083 6846614 SGTC_1992 st073643 23.3 µM 0.124029828270934 0.45355807910483 no 1494 0.450645828929725 2185 3161292 SGTC_904 1141-0088 396 µM 0.123472221858727 0.453769220047126 no 1495 0.450866584849323 2008 1378119 SGTC_3201 9113999 49.47 µM 0.123293331378324 0.453836960749428 no 1496 0.450937410666807 2137 16649224 SGTC_2150 5556613 200 µM 0.122682667777831 0.454068211673486 no 1497 0.451179194641999 2106 743190 SGTC_3285 9112818 20.8695 µM 0.122593352980865 0.454102035414672 no 1498 0.451214559145791 2176 17017947 YPR165W RHO1 SGTC_1067 clotrimazole 1.36 µM 0.122197874248571 0.454251808215052 no 1499 0.451371154971711 2083 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_485 niflumic acid 177 µM 0.122072348609491 0.454299347724065 no 1500 0.451420860343254 2159 4488 A COX2 inhibitor. SGTC_794 k038-0031 316 µM 0.122014639836502 0.454321203612106 no 1501 0.451443711994201 2186 6624242 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.121362315213943 0.454568266360183 no 1502 0.451702032150608 2042 2374 Ca(2+)-ATPase inhibitor. SGTC_3313 9133968 57.047 µM 0.119710878429755 0.455193813231871 no 1503 0.452356091297151 2197 1494643 SGTC_1094 duloxetine 25.4 µM 0.119195073969064 0.455389217377751 no 1504 0.452560404615657 2113 60834 A selective serotonin reuptake inhibitor. SGTC_1349 flufenamic acid 69 µM 0.118104517348555 0.455802392524422 no 1505 0.4529924220898 2153 3371 A non-steroidal anti-inflammatory. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.117445622483894 0.45605204877544 no 1506 0.453253466344057 2058 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_162 k030-0015 37.8 µM 0.117215646463918 0.456139191124089 no 1507 0.453344584152566 2173 1809920 YMR134W ERG29 SGTC_2105 5350118 200 µM 0.116351634562351 0.456466600713186 no 1508 0.453686932497264 2085 2133313 SGTC_2697 mebhydrolin 72.4 µM 0.115793824235384 0.456677993667444 no 1509 0.453907972568638 2172 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_45 0kpi-0036 14.9 µM 0.115308391448333 0.456861967740444 no 1510 0.454100343658302 2125 2795021 SGTC_1135 dihydrocapsaicin 536.708 nM 0.114462711042942 0.457182494047203 no 1511 0.45443550217674 2132 107982 A Capsaicinoid. SGTC_2178 5812956 200 µM 0.114259264327582 0.45725960774848 no 1512 0.454516136658946 2224 5403383 SGTC_2396 5342950 42.78 µM 0.112783455758017 0.457819040845613 no 1513 0.455101117519066 2091 1886677 SGTC_1863 st057641 20.1 µM 0.112467858208712 0.457938684939478 no 1514 0.455226226726724 2241 3921635 SGTC_2677 mitomycin C 100 µM 0.111384162806739 0.458349546463755 no 1515 0.455655859079997 2181 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1249 0481-0015 10.2 µM 0.111257841706047 0.458397441497289 no 1516 0.455705942617773 2143 4227577 SGTC_1719 st032227 49.2 µM 0.109720312217723 0.458980448739238 no 1517 0.456315595427243 2127 3125804 SGTC_2955 9076254 12.21 µM 0.109443854073205 0.459085286758456 no 1518 0.45642522605443 2201 16459619 SGTC_3202 9113761 49.47 µM 0.109316448676751 0.459133602189178 no 1519 0.456475750311449 2191 4798415 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.10831596155472 0.459513033780133 no 1520 0.456872530808943 2241 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_307 1501-1223 22.3 µM 0.108145084631673 0.459577842012056 no 1521 0.45694030273855 2150 2830329 SGTC_72 0744-0168 198.391 µM 0.107315369561212 0.45989254202949 no 1522 0.457269395904804 2093 677577 SGTC_1998 st075797 76.8 µM 0.107044026486181 0.459995464352542 no 1523 0.457377026150244 2228 24208315 SGTC_1379 2144-0755 36.5 µM 0.106714025779937 0.460120639536556 no 1524 0.457507927592885 2208 5392327 SGTC_2666 tannic acid 100 µM 0.106603544058717 0.460162548117863 no 1525 0.457551753428887 2215 16134267 A thiamine antagonist. SGTC_1672 st016598 6.51 µM 0.106437653325419 0.460225475605049 no 1526 0.457617559854362 2065 4665860 YNL267W PIK1 SGTC_1308 1187-1617 41.4 µM 0.106033209670092 0.460378897767518 no 1527 0.457778001598015 2165 2882570 SGTC_2726 cimetidine 79.27 µM 0.105877488937003 0.460437970639394 no 1528 0.457839777442878 2222 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2673 kobusone 100 µM 0.103976971435136 0.461159004507556 no 1529 0.458593811815204 2228 6710676 An epoxy ketone and protein crosslinker. SGTC_609 0986-0026 86.3 µM 0.103950496809179 0.461169049574949 no 1530 0.458604316738168 2166 2848610 SGTC_1034 k072-0165 12.7 µM 0.103889701713699 0.461192116692667 no 1531 0.458628439862406 2210 5835461 SGTC_2836 9010338 19.48 µM 0.103321769697718 0.461407610021112 no 1532 0.458853799181162 2066 2994051 SGTC_3325 9138760 55.175 µM 0.102522497126874 0.461710901251752 no 1533 0.459170978403814 2104 43844959 SGTC_1820 st053765 18.6 µM 0.102456857973912 0.461735809615877 no 1534 0.459197027465855 2116 3690829 SGTC_3154 9100113 49.47 µM 0.102254501125518 0.461812599760286 no 1535 0.459277334389349 2129 25237525 SGTC_3261 9137475 49.47 µM 0.101631393814777 0.462049064735274 no 1536 0.459524629899986 2230 17027690 SGTC_1634 st006576 41 µM 0.100855463623653 0.462343543695254 no 1537 0.459832598824141 2218 3915356 SGTC_772 k072-0172 35.3 µM 0.0969890370500582 0.463811224129873 no 1538 0.461367550284587 2033 5861980 SGTC_2817 7995342 71.43 µM 0.0965457494304939 0.463979526234757 no 1539 0.46154357040481 2150 18879975 SGTC_1648 st011736 69.8 µM 0.0949615830326758 0.464581035924085 no 1540 0.462172670637764 2214 2855514 SGTC_3164 9100705 49.47 µM 0.0914355978428319 0.465920144918953 no 1541 0.463573238609347 2247 17174235 SGTC_2608 thymoquinone 42.66 µM 0.0909477839126587 0.466105439058054 no 1542 0.46376704070972 2260 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_36 0335-0881 14.2 µM 0.0887715214435835 0.466932172460185 no 1543 0.464631745454493 2199 23828853 SGTC_2762 leflunomide 42.06 µM 0.0886541717692547 0.466976756139649 no 1544 0.464678377343882 2176 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1055 3448-0672 86 µM 0.0884732757367577 0.467045483266466 no 1545 0.464750261951328 2175 748378 SGTC_3236 9132701 49.47 µM 0.0867728935412233 0.467691550611535 no 1546 0.465426017077107 2151 24282524 SGTC_374 0880-0231 82.3 µM 0.0862394794986759 0.467894241132218 no 1547 0.465638023746327 2235 6833587 SGTC_709 3807-1509 243 µM 0.0861351974611903 0.467933867948407 no 1548 0.465679472029653 2249 1886677 YPL242C IQG1 SGTC_653 0203-0016 55.2 µM 0.0851695615667224 0.46830082131539 no 1549 0.466063294491021 2199 295302 SGTC_1381 2324-0066 62.1 µM 0.0847861759940202 0.468446519976154 no 1550 0.466215691960957 2182 10885928 SGTC_3194 9111903 49.47 µM 0.0830631772312539 0.469101365977728 no 1551 0.466900652470813 2229 17087251 SGTC_2524 avocatin b 10.57 µM 0.0815343405686401 0.469682488436173 no 1552 0.467508507978048 2233 6710748 SGTC_2686 alizarin 95.37 µM 0.0812857087745985 0.469777001412852 no 1553 0.46760736956215 2169 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1009 4106-0057 9.87 µM 0.0801883909765288 0.470194147625245 no 1554 0.468043711543625 2275 2928005 SGTC_2322 7413319 38.22 µM 0.0798476591230351 0.47032368378091 no 1555 0.468179209401937 2189 1840400 SGTC_2155 5570423 76 µM 0.0795921479392763 0.470420823624028 no 1556 0.468280820220695 2157 797402 SGTC_799 1310-0557 151 µM 0.079470297493454 0.470467149156595 no 1557 0.468329278019786 2169 5354492 SGTC_2406 ethylparaben 405.7 µM 0.0789880174102869 0.470650508016403 no 1558 0.468521077002427 1923 8434 A possible steroid mimic. SGTC_222 nsc-310342 10.666 µM 0.0788785772869258 0.470692117104923 no 1559 0.46856460149445 2269 432556 SGTC_550 4123-0385 25.7 µM 0.0780082195876848 0.471023038086928 no 1560 0.468910757316959 2209 5731123 SGTC_328 k915-0120 63.5 µM 0.0777114005936732 0.47113589700155 no 1561 0.469028812585629 2266 6624543 SGTC_1792 st045773 43.6 µM 0.0763862441594244 0.471639786831046 no 1562 0.469555906600296 2177 2919270 SGTC_27 0485-0001 32.618 µM 0.0763785582347239 0.47164270953187 no 1563 0.469558963909017 2266 2054479 SGTC_2128 5255449 168.493 µM 0.0751189863687081 0.472121703220648 no 1564 0.47006002078329 2248 736008 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0717049815796095 0.473420191775469 no 1565 0.471418345821583 2195 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_722 3534-0461 190 µM 0.0713398611248453 0.473559079291421 no 1566 0.47156363571988 2204 658262 SGTC_2712 st079126 47.7 µM 0.0711784550261554 0.473620477293745 no 1567 0.471627864157951 2267 3152970 SGTC_1105 epirubicin 18.1 µM 0.0708607566500198 0.473741329857865 no 1568 0.471754288241801 2242 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2807 7945238 51.95 µM 0.0707669949787177 0.473776997290054 no 1569 0.471791600067338 2232 17148797 SGTC_1969 st069479 40.1 µM 0.0703644158249593 0.473930142899864 no 1570 0.471951806539369 2284 3895485 SGTC_551 k048-0028 34.9 µM 0.0688963901738532 0.47448862873804 no 1571 0.472536045958716 2274 6836383 SGTC_813 k007-0158 173 µM 0.0668797644633739 0.47525590182595 no 1572 0.473338711291466 2254 6523916 SGTC_2586 curcumin 80 µM 0.0663621927344387 0.475452839180533 no 1573 0.473544734824535 2264 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1675 st018485 24.5 µM 0.065915423498711 0.475622840831478 no 1574 0.47372258055606 2153 3323024 SGTC_3089 9117425 49.47 µM 0.0658399597212415 0.4756515562439 no 1575 0.473752620990954 2131 9401657 SGTC_3166 9102297 49.47 µM 0.0642755466591638 0.476246873636507 no 1576 0.474375412061368 2219 25237072 SGTC_1268 0828-0275 2.46 µM 0.0642287598078686 0.476264678597876 no 1577 0.474394038826004 2253 745337 SGTC_3065 9113888 49.47 µM 0.0638534103970217 0.476407521334236 no 1578 0.474543474822647 2265 16648368 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0628084756421524 0.47680519695996 no 1579 0.474959508305325 2228 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1320 1313-0481 95.3 µM 0.0618678829653451 0.477163182408541 no 1580 0.475334022082174 2266 6813365 YLR208W SEC13 SGTC_3267 9137951 49.47 µM 0.0613974828304558 0.47734222156851 no 1581 0.475521328495005 2161 16643986 SGTC_2919 7978188 46.38 µM 0.060946545217064 0.47751385738531 no 1582 0.475700890297297 2299 2980291 SGTC_2636 apigenin dimethyl ether 100 µM 0.0600574069090251 0.477852293284558 no 1583 0.476054956528678 2253 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1370 2001-0092 44.6 µM 0.0590737198594772 0.478226736210535 no 1584 0.476446695295253 2271 790957 SGTC_735 3076-0345 636 µM 0.0581575826170017 0.478575483426794 no 1585 0.476811553835006 2293 2888990 SGTC_1984 st072354 53.1 µM 0.057862773555787 0.478687712296741 no 1586 0.476928967907657 2227 5762938 SGTC_812 4251-0442 148 µM 0.0576553121776722 0.478766690380822 no 1587 0.477011595081226 2299 5723007 SGTC_235 0330-0087 5 mM 0.0571667948986478 0.478952666397844 no 1588 0.477206164359241 2292 46494818 YHR062C RPP1 SGTC_70 0141-0289 43.283 µM 0.0570910199076328 0.478981513958973 no 1589 0.477236344916416 2184 352408 SGTC_1691 st019933 84.6 µM 0.0568787189069295 0.479062337597622 no 1590 0.477320903357822 2310 6176082 SGTC_1764 st044502 93.5 µM 0.0562225476631206 0.479312149420206 no 1591 0.477582259565993 2245 8407 SGTC_2946 9065502 71.43 µM 0.0551956168040269 0.479703129901341 no 1592 0.477991310448966 2321 16489101 SGTC_1720 st037298 9.481 µM 0.0551072247080339 0.479736784092199 no 1593 0.478026520204169 2254 597396 SGTC_2345 9052315 157.45 µM 0.0540367652787488 0.480144359599036 no 1594 0.478452936281239 2241 6469265 SGTC_1534 6-azauridine 81.6 µM 0.0535789291853523 0.480318686233034 no 1595 0.478635322233992 2322 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2692 st077426 47.7 µM 0.0529823853209195 0.480545833172286 no 1596 0.47887297123822 2299 25238571 SGTC_191 3914-0123 66.505 µM 0.0527333579191455 0.480640657598267 no 1597 0.478972180108121 2287 3144412 SGTC_2181 6316240 54.2555 µM 0.0510494446226903 0.481281885039377 no 1598 0.479643060385591 2246 12779990 SGTC_2297 7971671 152.32 µM 0.0503443113990672 0.481550411429789 no 1599 0.479924006563711 2278 909016 SGTC_2529 gangaleoidin 93.61 µM 0.0494806965846958 0.481879301622374 no 1600 0.480268110124017 2297 4565183 SGTC_3055 9094636 49.47 µM 0.0493513260385528 0.481928570839521 no 1601 0.480319658527127 2280 25236176 SGTC_2981 9013952 38.96 µM 0.0487637789067615 0.48215233456296 no 1602 0.480553774030526 2168 2996344 SGTC_244 nsc-207895 1.295 µM 0.047935318522932 0.482467858158571 no 1603 0.480883895810898 2305 42640 SGTC_1458 k015-0034 6.33 µM 0.0476028033218039 0.482594501461719 no 1604 0.481016398918313 2219 3598957 SGTC_3210 9128157 49.47 µM 0.0459546679538263 0.483222243725833 no 1605 0.481673190720534 2135 17590849 SGTC_78 0336-0123 156.75 µM 0.0432725251375344 0.484243907263724 no 1606 0.482742146232319 2199 6765896 SGTC_2593 nobiletin 86.24 µM 0.0432249908471854 0.484262014653968 no 1607 0.482761091943668 2276 72344 An anti-infammatory. SGTC_2331 7980721 200 µM 0.042440087717397 0.484561014994686 no 1608 0.483073935872604 2288 2981221 SGTC_2048 5246248 200 µM 0.0402050255983672 0.485412484676589 no 1609 0.483964835511651 2356 677046 SGTC_2265 7929201 200 µM 0.0401029063117752 0.485451389677498 no 1610 0.48400554238279 2336 1265108 SGTC_1395 3486-0190 4.35 µM 0.0392930720361606 0.485759922002292 no 1611 0.484328365033386 2343 6748079 SGTC_1526 st051518 75 µM 0.0386334070750245 0.486011248821877 no 1612 0.484591333585984 2192 673993 SGTC_2643 anethole 100 µM 0.0385815783948236 0.486030995351234 no 1613 0.48461199483392 2321 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3242 9133940 49.47 µM 0.0376725166088547 0.486377349948006 no 1614 0.484974394502541 2326 17248444 SGTC_1072 oxiconazole 14.9 nM 0.0364390077990377 0.486847335977263 no 1615 0.48546615554714 2338 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0353814080718543 0.487250312482671 no 1616 0.48588780481931 2310 521171 SGTC_2880 9042983 58.44 µM 0.0349873111145112 0.487400478329845 no 1617 0.486044929471671 2303 6464714 SGTC_3302 9125395 16.351 µM 0.0349576229772356 0.487411790705698 no 1618 0.486056766084119 2276 17599668 SGTC_1904 st060225 78 µM 0.0341729743025987 0.487710777092192 no 1619 0.486369608665958 2348 66595 SGTC_2576 guaiol 23.12 µM 0.0341309197508495 0.487726801961746 no 1620 0.486386376223415 2343 227829 SGTC_221 trifluoperazine 10.304 µM 0.0340874707218426 0.487743358217095 no 1621 0.48640369979775 2329 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1241 0364-0022 50.8 µM 0.0334538178546275 0.487984814069268 no 1622 0.486656346605936 2310 4563895 SGTC_678 1218-2179 85.9 µM 0.0323846850832335 0.488392221145284 no 1623 0.487082637807916 2362 6820081 YOR116C RPO31 SGTC_503 tyrphostin 8 294 µM 0.0317758274466423 0.488624239780072 no 1624 0.487325411901393 2337 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1509 1326-1131 80 µM 0.0317271828045371 0.488642777061243 no 1625 0.487344808525945 2334 768313 SGTC_384 k007-0144 5.16 µM 0.0310461507629154 0.488902304243018 no 1626 0.487616367204133 2303 6824886 SGTC_408 cantharidin 100 µM 0.03055300965373 0.489090233028143 no 1627 0.487813008750202 2274 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1339 1486-1321 22.7 µM 0.0303795313259932 0.489156343631845 no 1628 0.487882184478097 2333 3469382 SGTC_2963 9082507 9 µM 0.0302241446880444 0.489215559952787 no 1629 0.487944146324464 2332 16459611 SGTC_2446 5162541 200 µM 0.0300040710148164 0.489299428273739 no 1630 0.488031903216733 2352 1549321 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0289457923714034 0.489702736363387 no 1631 0.488453911937936 2338 23847180 SGTC_2944 9067346 25.62 µM 0.0283640449773901 0.489924443761119 no 1632 0.488685900303767 2328 6473075 SGTC_1896 st058441 89 µM 0.0271959012385069 0.490369639631713 no 1633 0.489151742418187 2280 688759 SGTC_1895 st058434 18.3 µM 0.0269905496350142 0.490447903247477 no 1634 0.489233635792884 2365 5393175 SGTC_154 3389-1638 511.116 µM 0.0267455740099053 0.490541268853595 no 1635 0.489331331657831 2226 5238686 SGTC_459 nigericin 15.3 µM 0.0263931184288239 0.490675598346001 no 1636 0.489471891468899 2326 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1881 5652484 16 µM 0.0257288797070472 0.49092875892565 no 1637 0.489736794401338 2350 2255129 SGTC_736 0958-0254 92.6 µM 0.0245799398314003 0.491366661695832 no 1638 0.490195010080556 2330 6812352 SGTC_3341 9147222 25.867 µM 0.0232117536769004 0.491888140725752 no 1639 0.490740681527922 2332 1939759 SGTC_599 1935-0052 86.5 µM 0.0229197408271072 0.491999442155668 no 1640 0.490857146814153 2363 9557311 SGTC_1753 st043925 64 µM 0.0224381503132291 0.492183002944282 no 1641 0.491049224227744 2361 670181 SGTC_3121 9125696 49.47 µM 0.0221399150741257 0.49229667772608 no 1642 0.491168173323004 2376 1235365 SGTC_2330 7979373 200 µM 0.0217178921631459 0.492457536250456 no 1643 0.49133649562823 2348 1863007 SGTC_733 4069-0007 56.1 µM 0.0215813569424801 0.492509578366908 no 1644 0.491390952536834 2359 5717425 YNL287W SEC21 SGTC_2291 7917025 104.35 µM 0.0211788269066566 0.492663008491044 no 1645 0.491551502087709 2345 2964612 SGTC_2035 5154463 94.595 µM 0.0207942852454616 0.492809583101067 no 1646 0.491704878234119 2364 2769623 SGTC_608 k048-0125 159 µM 0.0206347790144161 0.492870381906374 no 1647 0.4917684983627 2373 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_521 r062-0005 13.8 µM 0.020008295307873 0.493109179564482 no 1648 0.492018377596137 2366 2832033 SGTC_2065 5221596 34.26 µM 0.0198677642747942 0.493162746314238 no 1649 0.492074430224625 2349 788581 SGTC_317 4495-0002 170 µM 0.0195017949553606 0.493302244811441 no 1650 0.49222040257447 2321 15991618 SGTC_1742 st038235 28.8875 µM 0.0189780331699931 0.493501891333721 no 1651 0.492429314622611 2333 564103 YBR002C RER2 SGTC_2537 larixol 68.93 µM 0.0188739555333605 0.493541563644967 no 1652 0.492470828156689 2367 6708759 SGTC_2012 4023501 200 µM 0.0185870538335971 0.493650925158145 no 1653 0.492585265298796 2348 3477460 SGTC_1131 3454-3128 32.3 µM 0.017361466959192 0.49411810101614 no 1654 0.493074124715439 2331 710982 SGTC_420 mitomycin C 81.9 mM 0.0168269412780481 0.494321856981212 no 1655 0.493287338453007 2375 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2765 myclobutanil 7.74 µM 0.0155309788521274 0.494815871235955 no 1656 0.493804284960285 2354 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_115 0527-0192 112.043 µM 0.0147119872142847 0.495128070811137 no 1657 0.494130977989959 2330 4233931 SGTC_1642 st009582 77.7 µM 0.0142281629810714 0.495312506001224 no 1658 0.494323975724702 2377 6739311 SGTC_394 menadione 8.33 µM 0.0115289538594862 0.496341469569703 no 1659 0.495400714743908 2392 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2449 5812982 45.77 µM 0.0112090314724134 0.496463428699587 no 1660 0.495528337061901 2390 776185 SGTC_3023 9089636 49.47 µM 0.00976137738355395 0.497015299742309 no 1661 0.496105835689087 2393 17249241 SGTC_1185 1319-0113 81.3 µM 0.00964695301404012 0.497058920569434 no 1662 0.496151482258631 2375 4672763 SGTC_400 oxethazaine 37.5 µM 0.00950781970870081 0.497111960977699 no 1663 0.496206985871068 2332 4621 A local anesthetic. SGTC_1499 4480-0877 67.3 µM 0.00866499505307098 0.497433263708619 no 1664 0.496543210371108 2386 2861909 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.00824646271940381 0.497592817790574 no 1665 0.496710174644479 2388 4330530 SGTC_1503 4585-0012 61.3 µM 0.0081627908180609 0.497624715476849 no 1666 0.496743553780105 2382 2922052 SGTC_2791 5663188 71.43 µM 0.0074513604783897 0.497895929958929 no 1667 0.497027364766842 2389 54690634 SGTC_3171 9103192 49.47 µM 0.00737787657216108 0.497923943861903 no 1668 0.497056679798128 2388 13018434 SGTC_1446 4239-0190 62 µM 0.007227286170592 0.497981352721262 no 1669 0.497116755074421 2384 1340085 SGTC_2575 plumbagin 510 nM 0.00703515214364788 0.498054599118984 no 1670 0.497193403512179 2396 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_561 1550-0330 72.9 µM 0.00698882048526031 0.49807226194027 no 1671 0.497211886715233 2385 6812934 SGTC_2046 4110841 106 µM 0.00517060751789525 0.4987654141805 no 1672 0.497937235237153 2395 44119630 YMR134W ERG29 SGTC_530 4358-1714 28 µM 0.00510198084326623 0.498791576621714 no 1673 0.497964612958085 2376 1564641 SGTC_85 0868-0259 160.055 µM 0.004396981268346 0.499060342801975 no 1674 0.498245863918174 2381 83173 SGTC_38 0929-0051 58.268 µM 0.00429670654613822 0.49909857045692 no 1675 0.498285867366566 2395 1379719 SGTC_1531 st059297 52.4 µM 0.00312985651737933 0.499543408309725 no 1676 0.498751369942225 2404 7566702 SGTC_877 0771-0151 33.1 µM 0.00295499035436595 0.499610072541971 no 1677 0.498821131125106 2381 6166523 SGTC_1180 1193-0155 285 µM 0.00200181049050328 0.499973453471168 no 1678 0.499201393691356 2400 2921347 SGTC_1419 3993-2473 62.6 µM 0.00186254279425158 0.499973453471168 no 1679 0.499256953359929 2400 704026 SGTC_2194 5927483 104.545 µM 0.00184028346636254 0.49996496754221 no 1680 0.499265833531738 2393 760979 SGTC_848 0368-0089 85.6 µM 0.000798911261732766 0.499567965047837 no 1681 0.49968128055331 2403 762535 SGTC_1920 st075728 45.7 µM 0 0.499263396247363 no 1682 0.5 2405 3400306 SGTC_2760 etidronate 98.04 µM 0 0.499263396247363 no 1683 0.5 2406 3305 A chelator and antioxidant. SGTC_2957 9076800 11.52 µM -0.000634019988765651 0.499021689214882 no 1684 0.499747062636808 2411 16459615 SGTC_1405 3909-7894 12 µM -0.00134154055579182 0.498751962032255 no 1685 0.499464802911957 2410 7104060 SGTC_3123 9126162 49.47 µM -0.00194438460165133 0.498522140994477 no 1686 0.49922430326181 2415 25239884 SGTC_2259 7964009 200 µM -0.00210323402862782 0.498461583221584 no 1687 0.499160931639018 2418 313134 SGTC_1497 4476-2978 41.3 µM -0.0021985626682085 0.498425241337786 no 1688 0.499122901102142 2419 1528379 SGTC_3091 9116372 49.47 µM -0.00269575621534374 0.498235697782491 no 1689 0.498924550170612 2435 17169793 SGTC_1029 k015-0030 64.7 µM -0.00299058287244222 0.498123302114962 no 1690 0.498806931827523 2426 2208316 SGTC_3051 9093778 49.47 µM -0.00364816159133098 0.497872616380886 no 1691 0.498544597323828 2410 17217378 SGTC_2102 5377816 72.7585 µM -0.00379041794695592 0.49781838474675 no 1692 0.498487845641489 2415 1379702 SGTC_1726 st035556 14.5795 µM -0.00551385998883485 0.497161369597785 no 1693 0.497800299268368 2462 5919439 SGTC_2534 helenine 20.12 µM -0.00640957465272673 0.496819905804445 no 1694 0.49744296717993 2420 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3074 9116018 49.47 µM -0.00784291729041437 0.496273492756818 no 1695 0.496871160767717 2421 17027303 SGTC_990 3985-0011 41.3 µM -0.00808356267321762 0.496181755560772 no 1696 0.496775160194064 2431 5399565 YGL099W LSG1 SGTC_455 paf C-16 10 µM -0.00901229102631326 0.495827713991532 no 1697 0.496404664736075 2429 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1421 4029-0249 71.4 µM -0.00930545582151845 0.495715956982809 no 1698 0.496287713809876 2425 2894095 SGTC_2409 alverine citrate 63.97 µM -0.00963549366039382 0.495590144046975 no 1699 0.496156053666838 2490 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3113 9123498 49.47 µM -0.0107246933972388 0.495174935998727 no 1700 0.495721548376896 2418 8897275 SGTC_312 4092-0653 6.84 µM -0.0119157327250315 0.494720912219721 no 1701 0.49524642290348 2464 1148278 SGTC_2595 hexamethylquercetagetin 100 µM -0.0144474859238278 0.493755832227539 no 1702 0.494236487523027 2448 386331 SGTC_1217 1183-1422 255 µM -0.0147102664781013 0.493655664802088 no 1703 0.494131664390098 2450 2849664 SGTC_3069 9117009 49.47 µM -0.0155265351773732 0.493344519799499 no 1704 0.493806057516292 2429 41904981 SGTC_2027 5150920 200 µM -0.0155609687212276 0.493331394521595 no 1705 0.493792322179171 2450 786715 SGTC_2623 humulene 100 µM -0.0167725520039672 0.492869571435768 no 1706 0.493309033572297 2458 6187145 An anti-inflammatory. SGTC_2379 9035213 200 µM -0.0181044973794989 0.492361880597149 no 1707 0.492777745075206 2434 646551 SGTC_427 1354-0053 47.3 µM -0.0187382617382591 0.492120316156365 no 1708 0.492524952576771 2560 6813657 SGTC_2642 cholecalciferol 100 µM -0.0189744997974801 0.49203027283299 no 1709 0.492430723980522 2436 9821465 A vitamin D precursor, similar to steriods. SGTC_1148 3909-7663 27.7 µM -0.019262571317825 0.491920473475435 no 1710 0.492315821073156 2482 4084526 SGTC_3081 9117243 49.47 µM -0.0193305855413033 0.49189454973126 no 1711 0.492288692375011 2442 45595589 SGTC_353 1988-1175 58.3 µM -0.0195945659088845 0.491793933462458 no 1712 0.492183399389443 2394 2788357 SGTC_1785 bathophenanthroline 24 µM -0.0203790229928537 0.49149494030006 no 1713 0.491870508801258 2451 72812 An iron chelator. SGTC_984 1492-0255 2.91 µM -0.0206754284383707 0.491381967602601 no 1714 0.49175228504775 2471 1585198 SGTC_2251 lansoprazole 556 µM -0.0206887975681194 0.49137687207597 no 1715 0.491746952677224 2457 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1003 4049-0218 100 µM -0.0212907279227416 0.491147453067531 no 1716 0.491506870104963 2466 295161 SGTC_588 3970-1144 52.9 µM -0.0215498344573224 0.491048698413032 no 1717 0.491403525264976 2472 1888707 SGTC_224 benfluorex 43.875 µM -0.0225222440629301 0.490678083700454 no 1718 0.491015684151446 2442 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_820 1582-0060 59.9 µM -0.0233798436831694 0.490351233214088 no 1719 0.490673641511171 2457 3848840 SGTC_1735 st034310 56.75 µM -0.0240634592953459 0.490090696572893 no 1720 0.490400995067392 2592 871153 SGTC_524 r073-0010 27.8 µM -0.0240913313548978 0.490080074182413 no 1721 0.490389878946986 2455 2772106 SGTC_1714 st033236 13.627 µM -0.0247085179933569 0.48984485845204 no 1722 0.490143730389868 2463 2916566 SGTC_396 dithiazanine 1.25 µM -0.0248086002996342 0.489806716458609 no 1723 0.490103815561886 2461 10578 An antihelmenthic. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0255651157598157 0.489518406721013 no 1724 0.489802105280569 2460 5357218 A potent inhibitor of glutathione S-transferases. SGTC_412 gemfibrozil 100 µM -0.0256772435409056 0.489475675034691 no 1725 0.489757387447712 2447 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3328 9140624 29.0385 µM -0.0256837861192056 0.489473181674141 no 1726 0.489754778197133 2455 4904392 SGTC_3206 9114350 49.47 µM -0.0265437056816485 0.48914547205432 no 1727 0.489411836887024 2445 17087243 SGTC_442 cape 100 µM -0.0275935453664208 0.488745395096584 no 1728 0.48899316487913 2447 5281787 SGTC_510 ag-490 170 µM -0.0280798038767864 0.488560093640196 no 1729 0.488799250946664 2459 5328779 SGTC_1242 0402-0103 60.1 µM -0.0291134545087501 0.488166202428058 no 1730 0.488387052600358 2465 432868 SGTC_360 0957-0399 1.01 µM -0.0291813355654015 0.488140335527096 no 1731 0.488359983477835 2476 6752301 YPR165W RHO1 SGTC_1746 st038117 42 µM -0.0294531200780471 0.488036769238925 no 1732 0.488251603731113 2492 2898218 SGTC_2361 9034121 116 µM -0.0297759856823198 0.487913739023572 no 1733 0.488122855461137 2478 6496917 SGTC_397 arbidol 50 µM -0.032539613176155 0.486860687541683 no 1734 0.487020862998739 2553 131410 A RNA synthesis inhibitor. SGTC_2821 7996764 71.43 µM -0.0339239182187678 0.486333246494897 no 1735 0.486468910091141 2493 2987135 SGTC_769 0302-0231 76 µM -0.0339574919579146 0.486320454688406 no 1736 0.486455523819607 2484 571869 YER009W NTF2 SGTC_1673 st016611 27.3 µM -0.0356143525406105 0.485689198100455 no 1737 0.48579493195491 2558 5226799 SGTC_3012 9080433 71.4286 µM -0.0363454069482317 0.48541068089763 no 1738 0.485503472164882 2472 17688859 SGTC_2773 thioridazine 9.09 µM -0.0370983352826068 0.485123837604353 no 1739 0.485203299684186 2466 5452 An antipsychotic. SGTC_899 1083-0020 478 µM -0.0380922736429537 0.484745188474071 no 1740 0.484807055790332 2530 767123 SGTC_2852 9023854 51.95 µM -0.0383565594291049 0.484644508894676 no 1741 0.484701698013996 2519 19798528 SGTC_1267 0828-0272 9.49 µM -0.0399214135609179 0.484048398524847 no 1742 0.484077889578457 2487 745334 SGTC_511 blebbistatin 171 µM -0.0399381190978675 0.484042034962681 no 1743 0.484071230344263 2557 3476986 A myosin inhibitor. SGTC_499 genistein 192 µM -0.0407471491896529 0.483733859804002 no 1744 0.483748736583963 2464 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2896 9052656 71.43 µM -0.0409602211781161 0.483652698184969 no 1745 0.483663804065926 2478 6469436 SGTC_2830 7992007 71.43 µM -0.0411744774803021 0.483571086129961 no 1746 0.483578400216635 2476 1952075 SGTC_2210 7115885 190.385 µM -0.0417199878498884 0.483363299687305 no 1747 0.483360959916158 2482 2927039 SGTC_406 estrone 100 µM -0.0426026285255352 0.483027108951839 no 1748 0.483009150067003 2487 5870 A steroid. SGTC_2804 7954240 19.48 µM -0.0432747498261573 0.482771111434042 no 1749 0.482741259540569 2524 828705 SGTC_3105 9121040 49.47 µM -0.0436846765856717 0.482614982036588 no 1750 0.482577876934706 2481 41448907 SGTC_2495 cafestol 54.53 µM -0.0441763005891805 0.482427740009804 no 1751 0.4823819364984 2646 16667697 An anti-infammatory. SGTC_1520 flindersine 88 µM -0.048332151285438 0.480845083844168 no 1752 0.480725765733209 2608 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1301 naphtanilide LB 4.81 µM -0.0485378362508907 0.480766761288192 no 1753 0.480643805497847 2507 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2607 solasodine 47.35 µM -0.0490880960015256 0.480557232130033 no 1754 0.480424544993164 2520 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2114 5491910 81.25 µM -0.049206838531204 0.48051201778244 no 1755 0.480377230755287 2547 2849228 SGTC_766 1391-0721 126 µM -0.0495020056495705 0.480399626210563 no 1756 0.480259619441965 2501 1020919 YIL115C NUP159 SGTC_2879 9041815 71.43 µM -0.0496547518759182 0.480341465233291 no 1757 0.48019875736012 2488 4942971 SGTC_632 0781-2353 4.65 µM -0.0512487795246317 0.479734534651605 no 1758 0.479563641222822 2541 6811515 YHR007C ERG11 SGTC_2317 5986382 200 µM -0.0523531857288385 0.479314056301173 no 1759 0.479123637651743 2519 877883 SGTC_3176 9106582 49.47 µM -0.0524758239176076 0.47926736592198 no 1760 0.479074779253057 2483 17018027 SGTC_3228 9131799 49.47 µM -0.0532454054704185 0.478974380064008 no 1761 0.478768189284023 2531 17015818 SGTC_376 3970-0862 59.1 µM -0.0542459057494169 0.478593498607624 no 1762 0.478369623501342 2540 3135186 SGTC_657 3534-0529 86.7 µM -0.0553490353490055 0.478173569765253 no 1763 0.477930198725244 2543 1049549 SGTC_698 k064-0052 127 µM -0.0556747674251052 0.478049577801644 no 1764 0.477800450496871 2487 5088751 SGTC_2746 daunorubicin 9.88 µM -0.0563685679546116 0.477785485363288 no 1765 0.477524098133341 2478 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2634 4'-methoxyflavone 100 µM -0.0571245188374143 0.477497746746223 no 1766 0.477223002551436 2527 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2432 5630864 12.22 µM -0.0576646921912882 0.477292147001701 no 1767 0.477007859212645 2588 5714970 SGTC_941 3237-0776 460 µM -0.0578526625197435 0.477220603511054 no 1768 0.47693299488161 2549 760008 SGTC_3014 9081533 49.47 µM -0.0591513938707598 0.476726312837563 no 1769 0.476415761940435 2524 21367265 SGTC_740 k014-0057 261 µM -0.0592886314052539 0.476674082995101 no 1770 0.476361108005529 2574 4012779 SGTC_1136 pergolide 1.05886 µM -0.0622341923756602 0.475553159868939 no 1771 0.475188166837472 2535 47811 A dopamine receptor agonist. SGTC_299 1273-0059 1.44 µM -0.0627542011767969 0.475355292141075 no 1772 0.474981118054931 2538 2848077 SGTC_67 0335-0847 266 µM -0.0635311634525134 0.475059662791909 no 1773 0.474671772256312 2765 4552207 YOR254C SEC63 SGTC_1416 3966-0321 25.3 µM -0.0641038397553353 0.47484177177508 no 1774 0.474443772227123 2535 582530 YLR208W SEC13 SGTC_683 panaxydol 45 µM -0.0647807073885887 0.47458424790541 no 1775 0.474174301226901 2598 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1153 4055-0057 267 µM -0.0654834509977127 0.474316890391495 no 1776 0.473894541121899 2522 882706 SGTC_226 1,3-diallylurea 8.28947 mM -0.0657360128439997 0.47422080652062 no 1777 0.473794000152494 2604 74537 YKL182W FAS1 SGTC_1523 st012844 44.7 µM -0.0661950535576352 0.474046174292497 no 1778 0.473611267414153 2643 4274103 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0668608836491273 0.473792882337294 no 1779 0.473346226824379 2558 6857784 SGTC_294 k038-0071 157 µM -0.0669101150156651 0.473774154391516 no 1780 0.473326630234148 2574 24152826 SGTC_2356 9061756 188.97 µM -0.0692366858675031 0.472889177876192 no 1781 0.472400611029807 2518 20104043 SGTC_3300 9124615 50.48 µM -0.0694634858665753 0.472802915219047 no 1782 0.472310348238851 2642 24824903 SGTC_3245 9134821 49.47 µM -0.0698436332941053 0.472658330218761 no 1783 0.47215905880293 2529 17014901 SGTC_2183 6420625 130.508 µM -0.0702480082817285 0.47250453448026 no 1784 0.471998131796469 2517 2897619 SGTC_546 peri-Naphthalide 147 µM -0.0711797815147093 0.472150169271404 no 1785 0.471627336304453 2602 223824 A penicillin ester. SGTC_3293 9120939 62.045 µM -0.072199546375927 0.471762365002408 no 1786 0.471221553086443 2588 934087 SGTC_692 k241-0027 77.8 µM -0.0725392570736761 0.471633183050381 no 1787 0.471086382556875 2600 3600480 SGTC_1420 4'-methoxyflavone 42 µM -0.0727695727135234 0.471545602506869 no 1788 0.470994742099564 2530 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_825 1988-2224 89.6 µM -0.073314084134146 0.471338550375506 no 1789 0.470778092171353 2535 1180859 SGTC_2088 5278280 127.392 µM -0.0734323685290091 0.471293573395227 no 1790 0.470731030377463 2577 791502 SGTC_2034 5197015 53.07 µM -0.0736195912066865 0.471222383766699 no 1791 0.470656540955471 2617 780676 SGTC_1755 st041960 45.185 µM -0.0736343574928077 0.471216769067039 no 1792 0.470650666005064 2617 2257073 SGTC_1146 3579-1023 7 µM -0.0747164961509449 0.470805314725737 no 1793 0.470220141165153 2646 X1146 SGTC_1757 st041620 31.8375 µM -0.0771157034037487 0.46989319197736 no 1794 0.469265750345588 2596 5289815 SGTC_369 0957-0393 4.5 µM -0.0775615110917379 0.469723723531268 no 1795 0.469088429904986 2572 6997992 SGTC_1916 st067606 49.2 µM -0.0788082290611825 0.469249827857602 no 1796 0.468592579281853 2630 19590279 SGTC_1092 toremifene 6.32 µM -0.079005614326149 0.469174802818029 no 1797 0.468514078719171 2535 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1974 st069448 26.9 µM -0.0809147701251555 0.468449200221143 no 1798 0.467754866810482 2584 6323587 YNR016C ACC1 SGTC_2980 9014342 25.29 µM -0.0814040379416285 0.468263263601976 no 1799 0.467560318978822 2709 2996599 SGTC_2162 5663267 200 µM -0.0827461962132921 0.467753238389355 no 1800 0.467026675764568 2546 6456493 SGTC_2736 butenafine 14.65 µM -0.0838927940984734 0.467317568753517 no 1801 0.466570834420495 2589 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2748 diazoxide 86.69 µM -0.0846016631949998 0.467048241268294 no 1802 0.466289038386203 2629 3019 A potassium channel activatior. SGTC_963 1269-2853 151 µM -0.0871870759524558 0.466066069186622 no 1803 0.465261406065622 2592 3668223 SGTC_2350 9023895 38.85 µM -0.088285212462249 0.465648960441828 no 1804 0.464824995902761 2646 2997209 SGTC_1462 k081-0014 26.5 µM -0.0883600290713491 0.465620543974874 no 1805 0.464795264585871 2538 3270634 SGTC_183 3914-0051 30.55 µM -0.0890996572758777 0.465339631577638 no 1806 0.464501354883529 2608 1596232 SGTC_351 caspofungin 25 nM -0.0891658844760759 0.465314479183685 no 1807 0.464475038797222 2603 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_858 0438-0351 2.77 µM -0.0891982160048603 0.465302200059499 no 1808 0.464462191574913 2577 2799119 SGTC_2587 piperic acid 92.2 µM -0.0894541799602364 0.465204989207423 no 1809 0.464360483315372 2615 5370536 SGTC_1579 chlormadinone acetate 49.4 µM -0.0898476054467593 0.465055576803222 no 1810 0.464204158732011 2647 45114258 A steroidal progestin. SGTC_1290 0986-0249 10.2 µM -0.0903042354006632 0.464882167223235 no 1811 0.464022727271115 2581 53329 SGTC_2456 5770359 74.46 µM -0.0903193360440107 0.46487643272365 no 1812 0.464016727503689 2623 3118787 SGTC_19 0279-0214 38.434 µM -0.0904346512312289 0.464832641790756 no 1813 0.463970910897612 2574 3566274 YBR002C RER2 SGTC_642 0335-0876 158 µM -0.0906097948892347 0.464766131815892 no 1814 0.4639013243777 2574 6812350 SGTC_2281 7943571 200 µM -0.090722388168986 0.464723375570722 no 1815 0.463856590400571 2608 1244024 SGTC_639 0833-0042 114 µM -0.0910872722533697 0.464584817052964 no 1816 0.463711622934789 2594 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_563 tetrahydrosecaminediol 614 µM -0.0912200645707383 0.4645343924966 no 1817 0.463658866098879 2634 334274 A psychoactive constituent of the cannabis plant. SGTC_1100 amiodarone 5.07 µM -0.0918009407985237 0.464313826004648 no 1818 0.46342809828556 2569 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1106 tegaserod maleate 11.7 µM -0.0920385343621554 0.464223611699202 no 1819 0.463333711758285 2617 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2811 7967822 32.47 µM -0.0927644327807335 0.463947999393648 no 1820 0.463045353830396 2658 2232244 SGTC_2930 9013230 14.89 µM -0.092982716377595 0.463865123894471 no 1821 0.462958646031293 2629 2995857 SGTC_1256 0570-0116 285 µM -0.0930741904542461 0.46383039449587 no 1822 0.462922310723438 2603 410638 SGTC_873 0591-4978 488 µM -0.0931893357650505 0.463786678377626 no 1823 0.462876573174216 2709 3305145 SGTC_118 0083-0097 135.343 µM -0.0933259853381234 0.463734798509309 no 1824 0.46282229442679 2596 5207356 SGTC_3098 9119039 49.47 µM -0.0937255610484335 0.463583100623568 no 1825 0.462663582435368 2555 17161528 SGTC_1305 1181-0477 144 µM -0.0943165299579558 0.463358750517165 no 1826 0.462428859719891 2669 6252086 SGTC_792 4534-1957 155 µM -0.0954667579065349 0.462922121829661 no 1827 0.461972046490931 2637 1717904 SGTC_382 3229-0966 23.2 µM -0.0954850081292708 0.462915194369461 no 1828 0.46196479881447 2670 5722370 SGTC_1699 st031318 29.054 µM -0.0963001945134919 0.462605775607658 no 1829 0.461641078303436 2659 5340658 SGTC_3257 9139206 32.98 µM -0.0968388600221746 0.462401327757571 no 1830 0.461427181554131 2623 4910041 SGTC_780 0109-0199 192 µM -0.098644196288858 0.461716193975607 no 1831 0.460710388780718 2718 610414 SGTC_3064 1327-0027 10 µM -0.0989075116275895 0.461616273984288 no 1832 0.460605852368834 2590 16000455 YPR107C YTH1 SGTC_3288 9119690 36.221 µM -0.101196279878437 0.460747860261612 no 1833 0.459697324893502 2621 17595618 YKL019W RAM2 SGTC_2302 7771753 200 µM -0.10160589017799 0.460592463888351 no 1834 0.459534751981781 2645 2203047 SGTC_448 monastrol 171 µM -0.102236544245315 0.46035322055837 no 1835 0.459284460800288 2616 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1056 3448-1962 115 µM -0.103102688092156 0.460024665830513 no 1836 0.458940735803235 2675 715507 SGTC_1692 fluoroquinolonic acid 71 µM -0.103953213464369 0.459702062224444 no 1837 0.458603238789464 2699 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1630 st005209 31.3 µM -0.104227633910637 0.459597980415151 no 1838 0.458494352354149 2570 3367314 SGTC_1608 st001473 40.5 µM -0.105464590124277 0.459128863835926 no 1839 0.458003583120529 2593 7292267 SGTC_2404 5161160 200 µM -0.105639971934621 0.459062354742898 no 1840 0.457934004579989 2567 2831543 SGTC_1206 3978-0017 132 µM -0.105644971594615 0.459060458765736 no 1841 0.457932021103297 2864 3873677 SGTC_1306 1185-0270 9.02 µM -0.106102145721917 0.458887092576581 no 1842 0.457750654358822 2635 1548076 SGTC_1809 st050081 57.6 µM -0.107104108534516 0.458507163046295 no 1843 0.457353193889912 2730 5036894 SGTC_942 3253-1115 227 µM -0.107460754263162 0.458371937371398 no 1844 0.457211729272265 2709 46497897 SGTC_1066 ketoconazole 628 nM -0.108822018327078 0.457855845365862 no 1845 0.456671829715328 2720 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1490 4089-0339 670 nM -0.109086854773807 0.457755446938579 no 1846 0.456566800517864 2611 742542 SGTC_1688 st021091 57.6 µM -0.109928924389909 0.457436239690093 no 1847 0.456232871603546 2578 3656366 SGTC_504 lovastatin 124 µM -0.109938720560144 0.457432526371415 no 1848 0.456228987041449 2606 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_188 3229-0966 278.469 µM -0.111242706405003 0.456938273137541 no 1849 0.455711943478947 2632 5722370 SGTC_137 0438-0332 85.389 µM -0.113236995052953 0.456182501673257 no 1850 0.454921333233848 2587 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2187 6125751 200 µM -0.113555927025554 0.456061651310128 no 1851 0.454794913206682 2637 874498 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.113763520832365 0.455982991618443 no 1852 0.454712628479367 2602 88881 An O-methylated flavonoid and antioxidant. SGTC_424 splitomicin 100 mM -0.113768128495862 0.455981245741073 no 1853 0.454710802144726 2708 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_559 1550-0661 158 µM -0.114189035687727 0.455821764519439 no 1854 0.454543971655319 2687 5830875 SGTC_2272 7805186 180 µM -0.114550293369007 0.455684890099949 no 1855 0.454400790198651 2593 2956062 YPR165W RHO1 SGTC_465 cgp-37157 41 µM -0.114688317789965 0.455632596371292 no 1856 0.4543460869386 2592 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2104 5389443 200 µM -0.115059723042915 0.455491884762443 no 1857 0.454198892086534 2743 2244536 SGTC_278 4092-0821 23.9 µM -0.11526997138157 0.45541223197618 no 1858 0.454115569522353 2691 877900 SGTC_2998 9066762 71.4286 µM -0.116558201909157 0.454924223849668 no 1859 0.453605080960015 2716 4945196 SGTC_106 0092-0003 11.579 µM -0.116983084234644 0.454763284597372 no 1860 0.453436729129771 2731 1072148 SGTC_3258 9138477 49.47 µM -0.117113009038878 0.454714072450286 no 1861 0.453385250477762 2633 4970355 SGTC_2648 atorvastatin 78.68 µM -0.117758022166899 0.454469768507075 no 1862 0.453129695754022 2640 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_192 3455-0609 60.9 µM -0.117771253806523 0.454464757096426 no 1863 0.453124453570498 2720 3769639 SGTC_1463 k081-0032 34.1 µM -0.117849689942409 0.45443504999072 no 1864 0.453093378479958 2650 977755 SGTC_1843 st055809 45.5 µM -0.118488261977753 0.454193205059085 no 1865 0.45284039758159 2739 16413835 SGTC_97 0535-0701 19.132 µM -0.120601822805962 0.45339286259269 no 1866 0.452003212496543 2648 2832013 YGL099W LSG1 SGTC_2829 7992743 58.44 µM -0.121511600780232 0.453048414877877 no 1867 0.451642913348022 2732 16462845 SGTC_132 0417-1715 25.805 µM -0.122138109153441 0.452811235354271 no 1868 0.451394820530005 2650 6769098 SGTC_2108 5365811 200 µM -0.122926236735131 0.452512894986424 no 1869 0.451082754638245 2710 780283 SGTC_482 fipronil 114 µM -0.123242349770649 0.452393240057173 no 1870 0.450957595448124 2613 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2585 alliin 100 µM -0.123731620924914 0.45220804994221 no 1871 0.450763887077725 2751 87310 A garlic compound which reacts with lipids. SGTC_1101 ebselen 5.29 µM -0.123808360015781 0.452179004984371 no 1872 0.450733506205747 2636 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3048 9093155 49.47 µM -0.123809142781686 0.452178708716832 no 1873 0.45073319631158 2629 25236002 SGTC_1769 st044406 64.4 µM -0.124501356371685 0.451916724589984 no 1874 0.45045916325373 2632 670903 SGTC_1436 4092-1007 8.32 µM -0.124703902193968 0.45184007042735 no 1875 0.45037898400789 2641 2881121 SGTC_2383 9036125 200 µM -0.125112352742713 0.451685496377108 no 1876 0.450217302032476 2622 79580 SGTC_777 1315-0167 517 µM -0.126791498140664 0.451050117693248 no 1877 0.449552712464773 2726 4221767 SGTC_3068 9116768 49.47 µM -0.127160891303311 0.450910358277238 no 1878 0.449406529131337 2714 41904888 SGTC_770 0389-1121 67.2 µM -0.127486710503464 0.450787090063235 no 1879 0.449277595419047 2824 6753108 SGTC_3192 9110362 49.47 µM -0.128420658867902 0.450433772752179 no 1880 0.448908041552989 2619 16649480 SGTC_1442 4112-3290 3 µM -0.129131887077093 0.450164737912897 no 1881 0.448626645496845 2632 704353 SGTC_1237 0330-0133 46.1 µM -0.1293455919133 0.450083904690428 no 1882 0.448542098637263 2654 X1237 YHR072W ERG7 SGTC_3311 9131146 2.8755 µM -0.130127218901263 0.449788274256328 no 1883 0.448232887819135 2697 4900406 YPR165W RHO1 SGTC_2293 7624732 200 µM -0.130195706120786 0.449762372041079 no 1884 0.448205795842606 2623 894453 SGTC_2486 5283202 22.39 µM -0.13167566748269 0.449202695586095 no 1885 0.44762041622272 2706 1377751 SGTC_1311 1190-0148 100 µM -0.131956333291015 0.449096567663782 no 1886 0.447509415312446 2745 1961333 SGTC_3334 9142812 21.919 µM -0.132108995793053 0.449038843050985 no 1887 0.447449040333127 2750 45283678 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.135497801620042 0.447757750656586 no 1888 0.446109151141113 2729 1273210 SGTC_1819 st053448 58.6 µM -0.136729670387937 0.447292193563404 no 1889 0.445622238098913 2668 2857616 SGTC_1968 st069590 43.6 µM -0.136970672030875 0.447201120885879 no 1890 0.445526988459303 2754 6384066 SGTC_2857 9024691 58.44 µM -0.137216669509283 0.447108163191527 no 1891 0.445429767588118 2755 16478292 SGTC_2461 5755302 26.15 µM -0.137335949508812 0.447063090629941 no 1892 0.445382628019794 2815 2788904 SGTC_335 4077-0256 27.6 µM -0.138162733564594 0.446750690983013 no 1893 0.445055903443492 2749 3121989 SGTC_2513 baicalein 25.65 µM -0.139401823765188 0.4462825637378 no 1894 0.44456631563804 2701 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_379 3970-0972 5.9 µM -0.139458468180447 0.446261165309269 no 1895 0.444543936381484 2711 2898042 YBL034C STU1 SGTC_2285 7945142 200 µM -0.140549578193936 0.445849009840669 no 1896 0.444112891734963 2760 2970608 SGTC_3207 9114163 49.47 µM -0.140861714362021 0.445731114390451 no 1897 0.443989594010818 2849 849233 SGTC_2742 clothiapine 36.27 µM -0.140901804312688 0.445715972555584 no 1898 0.443973758367147 2651 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_624 k048-0052 28 µM -0.142217142135255 0.445219218080043 no 1899 0.443454245974695 2726 6835531 SGTC_410 α-linolenic acid 100 µM -0.142688219031123 0.445041330625238 no 1900 0.443268210679245 2777 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2427 5545055 42.75 µM -0.143158939199645 0.444863588931217 no 1901 0.443082328750875 2678 5372858 SGTC_1366 1683-0113 21.9 µM -0.143249494271198 0.444829397037696 no 1902 0.443046571040035 2663 708623 SGTC_1674 st016616 23.6 µM -0.144050593949767 0.444526934758401 no 1903 0.442730259012597 2627 625830 SGTC_684 1140-0066 328 µM -0.145040465551908 0.444153244598539 no 1904 0.44233946134118 2724 6813534 SGTC_1710 st031758 61.5 µM -0.145837829489806 0.443852264816899 no 1905 0.442024705768658 2819 5394341 SGTC_447 ml7 120 µM -0.146617337327156 0.443558056452717 no 1906 0.441717034183627 2724 4216 Selective myosin light chain kinase inhibitor. SGTC_593 1203-0218 61.7 µM -0.147977003934766 0.4430449542643 no 1907 0.441180458312687 2783 3666956 SGTC_3217 9129673 49.47 µM -0.148160695996157 0.442975641045951 no 1908 0.441107974732975 2812 17248312 SGTC_703 3875-0075 71.8 µM -0.148589547015859 0.442813827869613 no 1909 0.440938760856487 2693 2850814 SGTC_2657 nystatin 74.44 µM -0.149105339054529 0.442619222925474 no 1910 0.440735256516023 2709 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3120 9124077 49.47 µM -0.149245742832226 0.44256625189865 no 1911 0.440679863296615 2639 18774327 YGL155W CDC43 SGTC_2580 diallyl disulphide 81.36 µM -0.150136814637424 0.442230095541549 no 1912 0.44032833763709 2707 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2036 5160441 105 µM -0.150714922188767 0.442012027011117 no 1913 0.440100300748348 2712 134534 YIL048W NEO1 SGTC_357 1325-0123 420 µM -0.150940077973804 0.441927100522256 no 1914 0.440011492499519 2743 1098503 SGTC_309 k408-0051 1.48 µM -0.151581587994216 0.441685144069798 no 1915 0.43975847811714 2694 3640463 SGTC_2665 lovastatin 100 µM -0.153095199706019 0.441114345973341 no 1916 0.439161600666857 2692 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_486 niguldipine 82 µM -0.153666078090486 0.440899093730182 no 1917 0.438936516401816 2659 1236 A calcium channel blocker. SGTC_2362 9071156 126 µM -0.153742979469422 0.440870099054973 no 1918 0.438906197457764 2841 653133 SGTC_1297 1068-0111 14.1 µM -0.153925407138996 0.440801318318128 no 1919 0.438834275418147 2671 767057 SGTC_3326 9140064 16.379 µM -0.15441358716783 0.440617268503852 no 1920 0.438641820566458 2663 1868434 SGTC_2874 9043904 71.43 µM -0.155435089327432 0.440232191302058 no 1921 0.438239161515093 2764 4463428 SGTC_87 0100-0052 35.5 µM -0.155498057574264 0.440208455913403 no 1922 0.438214342573894 2702 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_514 4466-0038 2.65 nM -0.155502150143918 0.440206913258683 no 1923 0.438212729495538 2743 5722064 SGTC_983 1491-0821 12.2 µM -0.156448522435226 0.439850211756795 no 1924 0.437839746320361 2827 46495113 SGTC_2788 5282734 71.43 µM -0.15733506884949 0.439516103781826 no 1925 0.43749039173931 2822 743706 SGTC_2245 6637752 200 µM -0.157402941539456 0.439490526738719 no 1926 0.437463647670855 2856 681890 SGTC_63 0099-0242 26.702 µM -0.157949484143477 0.43928457765527 no 1927 0.437248302362927 2726 3898502 YLR359W ADE13 SGTC_2540 epiandrosterone 100 µM -0.158883230754838 0.438932759771014 no 1928 0.436880436390084 2712 441302 A steroid. SGTC_1729 st035615 45.989 µM -0.15911639561362 0.43884491522292 no 1929 0.436788585477602 2828 17385451 SGTC_3038 9091290 49.47 µM -0.15942202732193 0.438729773448978 no 1930 0.436668192773774 2793 25236843 SGTC_895 0964-0006 13.7 µM -0.160872712453468 0.438183322303414 no 1931 0.436096827325374 2660 6738897 SGTC_803 4488-1585 147 µM -0.162420008986506 0.437600609004417 no 1932 0.435487557573769 2817 747204 SGTC_752 1896-0090 130 µM -0.165382510607828 0.436485306748439 no 1933 0.434321459316327 2693 772567 SGTC_1198 1612-1005 86.7 µM -0.165483007804307 0.436447481056267 no 1934 0.434281911625796 2886 6998509 SGTC_1515 3460-0031 42.1 µM -0.16579985088397 0.436328229706694 no 1935 0.434157231737914 2730 2876596 SGTC_523 1934-0222 13.7 µM -0.166118640114714 0.436208251718 no 1936 0.434031792636533 2718 1361595 SGTC_1200 1643-0193 18.4 µM -0.166288163817161 0.436144452978702 no 1937 0.433965090136451 2679 5403974 SGTC_1388 3346-4487 254 µM -0.166569690042038 0.436038506756436 no 1938 0.433854322153042 2773 3345614 SGTC_359 0081-0058 15.9 µM -0.166794422904907 0.435953936764423 no 1939 0.433765903546258 3078 3494159 SGTC_807 1315-0151 48 µM -0.166975034316102 0.435885972388928 no 1940 0.433694846428219 2802 4011080 SGTC_2146 5545642 200 µM -0.167655048507623 0.435630098913742 no 1941 0.433427330808966 2709 825326 SGTC_831 k061-1017 217 µM -0.169799729566653 0.434823282459025 no 1942 0.432583819807473 2768 1240153 SGTC_1012 4112-3522 18 µM -0.169879639107549 0.434793226180059 no 1943 0.432552397000579 2759 3112398 SGTC_3198 9112019 49.47 µM -0.170356931634498 0.434613710572166 no 1944 0.432364720280423 2710 45595555 SGTC_3353 9151644 39.2805 µM -0.171011568518132 0.434367515494264 no 1945 0.432107334616312 2823 4909158 SGTC_2101 5377231 179.231 µM -0.171377889624264 0.43422976097862 no 1946 0.431963319548503 2832 2844213 SGTC_908 3448-7491 47.7 µM -0.172776209092225 0.433703998556366 no 1947 0.431413669089657 2731 1203031 SGTC_2924 9010168 62.78 µM -0.172900053086107 0.43365743935932 no 1948 0.431364994962645 2798 2993929 SGTC_466 geldanamycin 89.2 µM -0.173044944701933 0.433602968469302 no 1949 0.43130804985904 2724 5288382 HSP90 inhibitor. SGTC_1303 1160-0052 261 µM -0.174063709133999 0.433220007469854 no 1950 0.430907696840774 2729 3562476 SGTC_55 0767-0285 6.563 µM -0.174468096451961 0.433068012683258 no 1951 0.430748800779741 2819 3116166 SGTC_2518 prenyletin 46.28 µM -0.175646554124349 0.432625128973592 no 1952 0.430285812989693 2777 3873459 A coumarin with calcium channel inhibitory activity. SGTC_290 2043-6722 48.1 µM -0.176968372791631 0.432128468573882 no 1953 0.429766616148708 2789 773758 YLR208W SEC13 SGTC_1888 azatryptophan 97.5 µM -0.177172809007595 0.432051663227019 no 1954 0.429686326517055 2829 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2926 9010726 65.15 µM -0.177593775444893 0.431893516986338 no 1955 0.429521006655437 2826 2994293 SGTC_2279 7948423 32.93 µM -0.178230303516698 0.431654410530776 no 1956 0.429271055974047 2777 1247112 SGTC_1597 7-benzyloxygramine 47.5 µM -0.178839649467335 0.431425538268228 no 1957 0.429031805681579 2710 260807 SGTC_2789 5281112 71.43 µM -0.17975936481262 0.431080133900963 no 1958 0.428670743030879 2786 765948 SGTC_2619 obliquin 87.91 µM -0.179936132862026 0.431013753677449 no 1959 0.428601354105577 2737 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1854 st056233 32.9 µM -0.18101495413559 0.430608675275869 no 1960 0.428177919105461 2705 5393174 SGTC_2708 st078559 56 µM -0.181378129368668 0.430472325770845 no 1961 0.428035392195794 2758 17250902 SGTC_1345 1488-0192 31.4 µM -0.18233510190755 0.430113082386211 no 1962 0.427659876521944 2805 658348 SGTC_1930 st074634 34.3 µM -0.18251736143397 0.430044669490549 no 1963 0.427588365367686 2713 684253 YOR116C RPO31 SGTC_724 3910-0327 137 µM -0.183861912041597 0.429540044297026 no 1964 0.427060892574049 2784 2885483 SGTC_108 0509-0257 621.132 µM -0.186132187589054 0.428688245639868 no 1965 0.426170550452744 2837 536624 SGTC_1431 4049-0260 9.09 µM -0.187612571902253 0.428132989743853 no 1966 0.425590185148812 2705 3854841 SGTC_1333 1482-0047 286 µM -0.189565921915771 0.427400553867146 no 1967 0.424824646658845 2776 3811116 SGTC_3356 9151811 4.48 µM -0.189846508681907 0.427295364428158 no 1968 0.424714704956855 2731 1859254 YPR165W RHO1 SGTC_2312 7706453 155.7 µM -0.189976131533371 0.427246771739385 no 1969 0.424663917094157 2783 976098 SGTC_1435 4092-0789 56.7 µM -0.190647556166405 0.426995087443342 no 1970 0.424400864517703 2821 2248285 SGTC_1460 k062-0059 9.15 µM -0.190738029880503 0.426961175537225 no 1971 0.424365421050558 2652 1373085 SGTC_781 4335-2806 94.4 µM -0.191027399832246 0.426852715762782 no 1972 0.42425206323363 2921 845254 SGTC_1620 st003704 16.5 µM -0.191367965917796 0.426725074069304 no 1973 0.4241186578652 2759 2834414 SGTC_1997 st073024 93.8 µM -0.191777742549848 0.426571502937709 no 1974 0.423958153106366 2782 686268 SGTC_3268 9137683 49.47 µM -0.191785995714094 0.426568410030879 no 1975 0.423954920567045 2717 1953228 SGTC_2333 9017922 200 µM -0.192052817255025 0.426468420008307 no 1976 0.423850416605151 2886 3163164 SGTC_3243 9134147 49.47 µM -0.192257353157205 0.426391774413327 no 1977 0.423770311210754 2782 24282180 SGTC_285 1486-1325 46 µM -0.19301468862186 0.426108002851487 no 1978 0.423473732268244 2851 22310230 SGTC_2226 7298446 200 µM -0.193422468646085 0.425955224608756 no 1979 0.423314060122599 2834 3283010 SGTC_2326 6164455 177.58 µM -0.194191386693111 0.425667173197703 no 1980 0.423013013461358 2829 2888790 SGTC_818 4072-2707 53.5 µM -0.195797315640072 0.425065689596893 no 1981 0.422384405608931 2731 882871 SGTC_1088 bifonazole 369 nM -0.196292953928726 0.424880088701543 no 1982 0.422190438032468 2735 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_375 3970-0961 9.27 µM -0.196432657586645 0.424827777097475 no 1983 0.422135768544867 2806 2898222 SGTC_1943 st076331 65.2 µM -0.198306583069418 0.424126219805607 no 1984 0.421402600713327 2838 24208415 SGTC_2581 avocatin a 64 µM -0.199750796398861 0.423585701361368 no 1985 0.420837742235937 2821 6710728 A skin care supplement. SGTC_2566 crystal violet carbinol 226 nM -0.201295877950268 0.4230075906621 no 1986 0.420233612760076 2945 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1519 esterone 74 µM -0.202553274982136 0.422537242829508 no 1987 0.419742107003525 2755 698 A steroid. SGTC_1678 st019265 80.2 µM -0.202631353519102 0.422508040040195 no 1988 0.419711590890257 2973 5367020 SGTC_3094 9117742 49.47 µM -0.202759298253566 0.422460187309258 no 1989 0.419661586181444 2733 17149698 SGTC_2375 9072683 200 µM -0.20292194840059 0.422399356026428 no 1990 0.419598019410565 2844 16798029 SGTC_3292 9120825 59.784 µM -0.204651142748249 0.421752750698177 no 1991 0.41892234740912 2842 24824900 SGTC_1553 gossypol 38.6 µM -0.2050143249298 0.421616971112406 no 1992 0.418780466530438 2727 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1871 st057448 67.3 µM -0.207144059735085 0.420820934786006 no 1993 0.417948676771366 2945 691747 SGTC_158 k038-0087 26.446 µM -0.207146775527911 0.420819919903226 no 1994 0.417947616324085 2762 X158 SGTC_1156 4092-0367 4.88 µM -0.207653043534327 0.420630738426439 no 1995 0.417749942112135 2806 1357585 SGTC_2735 sertaconazole 140 nM -0.20784349339653 0.420559576147081 no 1996 0.417675585636688 2761 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2699 st077704 54.6 µM -0.20891940570696 0.420157606450796 no 1997 0.41725557743122 2825 645852 SGTC_1355 1499-0035 1.68 µM -0.209914709466029 0.419785826904044 no 1998 0.416867120753709 2777 1548538 SGTC_1046 2001-0062 216 µM -0.210339306040902 0.419627247514469 no 1999 0.416701429810953 2757 739778 SGTC_2369 9071472 200 µM -0.210344132121189 0.419625445132914 no 2000 0.416699546607576 2918 17296037 SGTC_705 1124-0212 310 µM -0.210384321653564 0.419610435735743 no 2001 0.416683864169604 2851 9554485 SGTC_2163 5671233 125 µM -0.2111197784129 0.419335788805121 no 2002 0.416396903553727 2941 701023 SGTC_378 3970-0959 8.33 µM -0.211184924715704 0.419311462643279 no 2003 0.416371486906504 2906 6615653 SGTC_1113 artemisinin 1.17947 µM -0.212047391556564 0.418989439580783 no 2004 0.416035030886972 2875 2240 An anti-malaria and mitochondrial poison. SGTC_650 1328-0195 38 µM -0.213423046137615 0.418475917730552 no 2005 0.415498503176815 2806 2780821 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.213706876381827 0.41836998322298 no 2006 0.415387824323439 2784 17037758 SGTC_341 1486-1430 230 µM -0.213941004478415 0.41828260359939 no 2007 0.415296531743531 2769 2054753 YPL210C SRP72 SGTC_495 decylubiquinone 155 µM -0.21452797236706 0.41806355735525 no 2008 0.415067677946389 2853 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2010 4012422 159 µM -0.21683017848176 0.417204659860304 no 2009 0.414170346188013 2871 952393 SGTC_2397 5161689 200 µM -0.217731348113497 0.416868562567186 no 2010 0.413819218661839 2990 2259942 SGTC_366 0181-0206 4.31 µM -0.21775408812131 0.416860082312693 no 2011 0.413810359241367 2941 274874 SGTC_2731 amoxapine 43.43 µM -0.218185524836116 0.41669919730364 no 2012 0.413642281456459 2788 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2768 sulfasalazine 50.2 µM -0.221460414904358 0.415478430410693 no 2013 0.412366977848629 2878 5384001 An antioxidant and salicylic acid derivative. SGTC_3225 9130819 49.47 µM -0.22288902907794 0.414946146687493 no 2014 0.411810937574902 2922 4547121 SGTC_879 0831-1030 162 µM -0.223806763714864 0.414604292557413 no 2015 0.411453833389758 2822 1549252 SGTC_2950 9072895 21.46 µM -0.22429271467712 0.414423303065228 no 2016 0.411264772329556 2919 17332245 SGTC_581 0958-0271 211 µM -0.224624749435195 0.414299649176669 no 2017 0.411135604797787 2794 4591145 SGTC_2447 5741742 33.78 µM -0.225236749015462 0.414071755158534 no 2018 0.410897551133684 2884 1776504 SGTC_2635 hydroquinidine 100 µM -0.225254468610831 0.414065157235274 no 2019 0.410890659109795 2791 442912 An experimental heart treatment. SGTC_1959 st077091 55.8 µM -0.225601105374174 0.413936091292399 no 2020 0.410755840524966 2776 821356 YKL052C ASK1 SGTC_883 0850-0245 24.6 µM -0.226195411895474 0.413714830193893 no 2021 0.410524719461711 3011 6823229 YPR165W RHO1 SGTC_1703 st026983 48.3 µM -0.226236371412176 0.413699581920223 no 2022 0.410508791776022 2948 1104023 SGTC_2 0422-0095 29 µM -0.226857408529475 0.413468400229854 no 2023 0.410267310833935 2798 6790840 SGTC_1645 Cervolide 78 µM -0.227391264511859 0.413269695775242 no 2024 0.410059756152469 2883 23173 A fragrance. SGTC_526 4469-0568 170 µM -0.227482693090475 0.413235667726836 no 2025 0.410024212706344 2780 2901964 SGTC_595 3909-8003 73.7 µM -0.227979237126574 0.413050874486637 no 2026 0.409831190945426 2916 699517 SGTC_3355 9151058 44.0485 µM -0.231025167932305 0.411917727488093 no 2027 0.408647624835745 2792 17015728 SGTC_262 fenpropimorph 62.5 µM -0.233335617106527 0.411058683379755 no 2028 0.4077504016709 2801 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2958 9077254 16.72 µM -0.234303516962555 0.410698936682903 no 2029 0.407374677884671 3004 16457351 SGTC_1602 st001878 87.6 µM -0.234808553475113 0.41051125572416 no 2030 0.407178664309349 3002 595405 YLR310C CDC25 SGTC_1261 0712-0010 12.7 µM -0.235388939353552 0.410295598846419 no 2031 0.406953435023121 2971 2840123 SGTC_6 0844-0013 19.835 µM -0.235923275099283 0.410097077025506 no 2032 0.406746103528875 2880 1584900 SGTC_2024 5144227 134 µM -0.236341410192405 0.409941743312388 no 2033 0.406583878118869 2978 3475211 SGTC_2764 methyldopa 94.69 µM -0.236773625693728 0.409781193698361 no 2034 0.406416206730998 2978 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2867 9039098 71.43 µM -0.239643608858828 0.408715502336653 no 2035 0.405303277335208 2806 6463460 SGTC_364 0083-0097 67.7 µM -0.240235704398707 0.408495727201137 no 2036 0.405073767945962 2976 5207356 SGTC_170 4197-0004 226 µM -0.242267174513465 0.407741901441875 no 2037 0.404286573586239 2972 218692 SGTC_1123 mangostin 811.285 nM -0.2428682216381 0.407518933805212 no 2038 0.404053742031662 2917 5281650 An antioxidant. SGTC_699 0375-0592 111 µM -0.243695123640939 0.407212230812648 no 2039 0.403733475152786 2918 762578 SGTC_933 2914-0560 114 µM -0.244112295145567 0.407057520934375 no 2040 0.403571925204917 3043 463887 SGTC_2304 7443016 91.4 µM -0.244869370584946 0.406776793246033 no 2041 0.403278789263631 2774 939854 SGTC_3042 9091578 49.47 µM -0.246045837052358 0.406340648177328 no 2042 0.402823375033475 2838 25236497 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.247145266977613 0.405933167455165 no 2043 0.402397901046463 2870 65057 A dermal irritant. YDR527W RBA50 SGTC_3142 9086498 49.47 µM -0.248102525362521 0.405578462601911 no 2044 0.402027540869398 2980 25236367 SGTC_3025 9087895 49.47 µM -0.248557718428514 0.405409821432211 no 2045 0.401851458977132 2973 17173641 SGTC_268 camptothecin 39.6153 µM -0.249537316270069 0.405046956940912 no 2046 0.401472589704676 2868 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2837 9008476 45.46 µM -0.249848534853608 0.404931691832309 no 2047 0.401352242168636 3039 2992805 SGTC_880 0833-0487 87.2 µM -0.252214790881346 0.404055579003004 no 2048 0.400437523044295 2851 76075 SGTC_303 1348-1668 34.2 µM -0.25263378227445 0.403900496287425 no 2049 0.400275611068557 2874 5380509 SGTC_1781 st038725 66.3 µM -0.252697616844931 0.403876870305111 no 2050 0.400250944806793 2855 4270275 YIL048W NEO1 SGTC_1687 st020778 55.3625 µM -0.253491408530408 0.403583107277159 no 2051 0.399944249707547 2892 4259299 SGTC_2886 9058944 51.95 µM -0.25366892034896 0.4035174218986 no 2052 0.399875673393025 2879 4949929 SGTC_572 0960-0087 17.7 µM -0.253955408103079 0.40341141747812 no 2053 0.399765004040645 2880 6796365 SGTC_233 rapamycin 362 pM -0.254584600316306 0.403178632597398 no 2054 0.399521977263986 2884 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.255158614195938 0.4029662921996 no 2055 0.399300297183764 2861 16623 A steroid. SGTC_719 2810-4230 27.3 µM -0.255396005546474 0.402878484261979 no 2056 0.399208627817428 2835 721079 SGTC_691 1548-0686 185 µM -0.255420402551336 0.402869460408316 no 2057 0.399199207157288 2872 46495133 SGTC_3239 9133757 49.47 µM -0.255535676771215 0.402826824001786 no 2058 0.399154695960867 2833 17036923 SGTC_1383 3049-0032 20.7 µM -0.257483031209361 0.402106732218378 no 2059 0.398402956481538 3009 712864 SGTC_17 0960-0276 49.807 µM -0.257853166757729 0.40196990116402 no 2060 0.398260115167459 2876 6821114 SGTC_1218 1348-1416 30.7 µM -0.259479613124488 0.401368781952564 no 2061 0.397632604930946 2852 6787668 SGTC_1575 cyproterone acetate 48 µM -0.259554000668155 0.401341294589022 no 2062 0.397603911291272 2918 9880 An androgen receptor antagonist and liver toxin. SGTC_2052 5265182 7.135 µM -0.26004344808719 0.401160448275522 no 2063 0.397415129688241 3020 1239884 SGTC_2937 9044753 11.33 µM -0.261491116979802 0.400625672027853 no 2064 0.396856899456447 2837 6465530 YGL099W LSG1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.26372095601513 0.399802322769215 no 2065 0.395997473229096 2854 91467 include heat shock SGTC_673 1082-0474 110 µM -0.270637656309283 0.397251237700747 no 2066 0.393334865359253 2907 3098046 SGTC_3274 9138298 49.47 µM -0.273140010532237 0.396329370457424 no 2067 0.392372795840152 2866 17015756 SGTC_2430 5571206 200 µM -0.273658967020762 0.396138259259461 no 2068 0.392173356953128 3057 1731771 SGTC_2526 patulin 37.61 µM -0.2758868692871 0.395318094870309 no 2069 0.391317479733099 3036 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3312 9133330 71.43 µM -0.277063995044471 0.394884942907793 no 2070 0.39086548386952 3045 17617324 SGTC_1201 1889-3372 45.9 µM -0.27864267497635 0.394304233341939 no 2071 0.390259529658564 2930 5392199 SGTC_131 0141-0277 33.849 µM -0.279254333718426 0.394079300767268 no 2072 0.390024824558119 3081 1547771 SGTC_1559 coumarin 343 70.1 µM -0.279648087698656 0.393934519598262 no 2073 0.389873754865651 3053 108770 A hepatotoxic, DNA x-linker. SGTC_2076 5212012 200 µM -0.281827218875584 0.393133530620943 no 2074 0.389037999451733 2864 604802 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.282455542740016 0.392902659807057 no 2075 0.388797115494204 2924 390807 SGTC_3336 9143619 71.43 µM -0.284232925985011 0.392249783785846 no 2076 0.388115942132731 2997 45595730 SGTC_804 1595-0054 20.9 µM -0.284446181657416 0.392171470134757 no 2077 0.388034236024769 2921 761523 Stimulates phospholipase C. SGTC_1857 st056007 79.3 µM -0.285723218504169 0.391702596755217 no 2078 0.387545059962104 2974 619834 SGTC_2137 5261020 140 µM -0.287043900328202 0.391217864223978 no 2079 0.38703935316746 2898 763655 SGTC_247 mechlorethamine 29.705 µM -0.287994155383252 0.390869194627041 no 2080 0.386675606279086 2897 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1085 doxorubicin 7.67 µM -0.28818264658777 0.390800043451088 no 2081 0.386603465797767 3013 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3298 9116858 71.43 µM -0.288851677998584 0.390554625893192 no 2082 0.386347441748083 3067 2506942 SGTC_3020 9089140 49.47 µM -0.289669294654034 0.390254762731066 no 2083 0.386034624478383 2997 17217859 SGTC_105 0111-0055 734.78 µM -0.289834711614975 0.390194103538633 no 2084 0.385971345531799 3008 5179370 SGTC_1512 0259-0544 12.2 µM -0.290422194589659 0.389978692332859 no 2085 0.385746633109788 2938 18476 SGTC_1990 st072050 59.8 µM -0.290878424443089 0.389811430747372 no 2086 0.385572151490116 2897 17233948 SGTC_3191 9110352 49.47 µM -0.291606372715675 0.389544594851767 no 2087 0.385293801196144 2919 17122424 SGTC_1708 st033234 31.827 µM -0.291892865396972 0.389439592688711 no 2088 0.385184269328659 3048 674664 SGTC_3000 9075062 71.4286 µM -0.292812048136651 0.389102758413291 no 2089 0.384832909305806 2952 17057871 SGTC_868 0527-0199 213 µM -0.293463243067654 0.388864178611428 no 2090 0.384584045534992 2950 2849450 SGTC_3135 9127742 49.47 µM -0.294216586619068 0.38858822666788 no 2091 0.384296203492893 2978 3643468 SGTC_3079 9117512 49.47 µM -0.29476049155841 0.388389027636504 no 2092 0.384088424663564 2925 7185044 SGTC_195 4234-0266 16.654 µM -0.295877559661674 0.387980006180656 no 2093 0.383661794494683 2961 2303354 SGTC_1140 3229-1848 2.98 µM -0.296590254975352 0.387719113235403 no 2094 0.383389675845176 3037 2849525 SGTC_1195 1502-0147 41.1 µM -0.296660711992277 0.387693324125204 no 2095 0.383362777333347 2940 817940 SGTC_443 clozapine 122 µM -0.297419341973986 0.38741567712712 no 2096 0.383073189338032 2951 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2085 5307070 144.047 µM -0.297591666082562 0.387352617152039 no 2097 0.383007418025794 2897 2840351 SGTC_1299 1079-1439 3.74 µM -0.297597863811713 0.387350349221515 no 2098 0.383005052588035 2954 323161 SGTC_2339 9000433 200 µM -0.299825169718664 0.386535562313759 no 2099 0.382155257698417 2988 2988954 SGTC_570 0987-0065 62.6 µM -0.300463123232648 0.386302279870813 no 2100 0.381911960528992 2872 3104428 SGTC_324 1315-0088 19.6 µM -0.300935003243792 0.386129752475964 no 2101 0.381732029026882 3009 6787421 SGTC_3130 9127414 49.47 µM -0.303745616109721 0.385102611910751 no 2102 0.380660851112408 2961 1494646 SGTC_1391 3442-0225 151 µM -0.303902466672776 0.385045314423962 no 2103 0.380601099243674 2935 5227075 SGTC_2800 7887935 81.82 µM -0.304012844078025 0.385004995079143 no 2104 0.380559052927006 3118 2961002 SGTC_1352 1496-0991 99 µM -0.304764221343041 0.384730560381186 no 2105 0.380272866588506 2930 3000039 SGTC_1022 4477-0945 21.3 µM -0.306092229544599 0.384245657025167 no 2106 0.379767212050146 2942 4648966 SGTC_509 pifithrin 175 µM -0.306300197350024 0.38416973691378 no 2107 0.379688044484466 3027 4817 A p53 inhibitor. SGTC_308 4092-1169 104 µM -0.306874600249095 0.383960070187909 no 2108 0.379469411467493 2964 2268590 YDL196W YDL196W SGTC_1646 st011709 75.6 µM -0.308839405847235 0.383243140174778 no 2109 0.378721845956768 3065 5757843 SGTC_2425 5628681 7.85 µM -0.310438261226434 0.38266003508199 no 2110 0.378113851034079 3032 5714958 SGTC_2984 9022109 38.96 µM -0.310754437236393 0.382544756637881 no 2111 0.3779936548267 3061 6459207 SGTC_2247 cerulenin 830 nM -0.31257894439387 0.381879741051715 no 2112 0.377300288508422 3178 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3188 9110789 49.47 µM -0.313362473106447 0.381594259076856 no 2113 0.377002645794944 3134 849217 SGTC_1382 3002-2117 298 µM -0.314204657872848 0.381287477333747 no 2114 0.376682802617601 3120 1497314 SGTC_1346 1488-2224 62.4 µM -0.315043625629236 0.380981941598946 no 2115 0.37636426533028 3068 3722427 SGTC_3044 9093193 49.47 µM -0.316002049026374 0.380632993239262 no 2116 0.376000476434895 3066 25236277 SGTC_887 0885-0007 9.62 µM -0.3177784507938 0.379986487490721 no 2117 0.375326498918672 3090 5719458 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.318047394431109 0.379888637001902 no 2118 0.37522449318932 2982 4174840 SGTC_2399 5884133 200 µM -0.319041968133227 0.379526845411444 no 2119 0.374847344210737 2973 722445 SGTC_1065 prochlorperazine maleate 2.48 µM -0.319387419117977 0.379401206924219 no 2120 0.374716374874984 2998 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1010 4112-3296 15.2 µM -0.319776659232648 0.379259657847169 no 2121 0.374568821269643 3130 704384 SGTC_2757 clomiphene 4.22 µM -0.320385093873305 0.379038430035332 no 2122 0.374338211939973 3193 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2223 6903751 107.57 µM -0.32045061723409 0.379014607997773 no 2123 0.374313379908838 3057 5598863 SGTC_988 1497-1057 103 µM -0.32385195887503 0.377778630324933 no 2124 0.373025058338873 3036 3533044 SGTC_3137 9097352 49.47 µM -0.323921500285702 0.377753373404876 no 2125 0.372998732983116 3276 44120435 SGTC_2129 girgensonine 121.053 µM -0.324069968519219 0.377699452602405 no 2126 0.372942531347067 3034 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3100 9120536 49.47 µM -0.324115882786472 0.377682777907401 no 2127 0.372925151362069 2945 16421196 SGTC_2250 alverine citrate 130 µM -0.324996678772983 0.377362943190178 no 2128 0.372591792665564 2946 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1704 st028805 70.8 µM -0.324998675902434 0.377362218087828 no 2129 0.372591036911602 3038 2876101 SGTC_2783 7738165 71.43 µM -0.325047277404131 0.377344572362902 no 2130 0.372572645276843 3029 17201110 SGTC_1605 st000082 49.1 µM -0.326045817537304 0.376982089580791 no 2131 0.372194845071769 3105 1114022 SGTC_2521 angolensin 13.4 µM -0.328487444077872 0.376096205208722 no 2132 0.371271568132202 3141 821428 A flavenoid. SGTC_631 k072-0230 41.5 µM -0.328796660861052 0.375984059927685 no 2133 0.371154693568038 3087 5773147 SGTC_3354 9151612 71.43 µM -0.329826065123104 0.375610795969604 no 2134 0.370765695659121 3107 27261949 SGTC_3182 9108849 49.47 µM -0.334298528021616 0.37399042789497 no 2135 0.369077150540291 3095 17133045 SGTC_1942 st076330 65.2 µM -0.334893716733497 0.373774958788666 no 2136 0.368852631011975 3140 24208414 SGTC_477 mead ethanolamide 10 µM -0.335233847673005 0.373651842927272 no 2137 0.36872434551143 3006 16061185 SGTC_380 3970-0968 6 µM -0.335847435137625 0.373429777695458 no 2138 0.368492958770801 2988 2891601 SGTC_1989 st071868 50.2 µM -0.337226044612524 0.37293099449983 no 2139 0.367973252623137 3131 16414057 SGTC_634 1611-4317 11.2 µM -0.337291950647946 0.372907154913456 no 2140 0.367948413507035 3077 2843522 SGTC_844 0330-0132 15.3 µM -0.33750590174685 0.372829767697594 no 2141 0.367867781963938 3121 2828079 SGTC_464 bw-b 70c 158 µM -0.33762521541933 0.372786613555722 no 2142 0.367822818864472 3113 5353454 SGTC_980 1473-0395 201 µM -0.33979538794686 0.372001970609527 no 2143 0.367005310685167 2987 768876 SGTC_2376 9072922 81.32 µM -0.340003405412793 0.371926788109461 no 2144 0.366926981700246 3122 17087968 SGTC_3072 9116419 49.47 µM -0.341169896607091 0.371505280766187 no 2145 0.366487842114346 3059 17170162 SGTC_3103 9120822 49.47 µM -0.341795696967859 0.371279213535956 no 2146 0.366252324051651 3226 17141819 SGTC_1108 betulinic acid 729.144 nM -0.342405883848655 0.371058829350053 no 2147 0.366022730575536 3042 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1750 st081859 2.357 µM -0.342891377213215 0.370883511532383 no 2148 0.365840089473426 3038 5291695 SGTC_1495 4469-0029 237 µM -0.342986126017047 0.370849299660815 no 2149 0.365804448810887 2999 793680 SGTC_1254 0550-0035 264 µM -0.343902274526954 0.370518549714121 no 2150 0.365459890631501 3145 15121435 SGTC_2794 7785382 27.27 µM -0.34392445433716 0.370510543495679 no 2151 0.365451550277259 3099 2205081 SGTC_852 0418-0143 439 µM -0.344294628379787 0.370376930514323 no 2152 0.365312361787766 3111 5369229 SGTC_1876 myriocin 605 nM -0.344504730473745 0.370301101878856 no 2153 0.365233369559609 3193 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1846 st056244 14.8 µM -0.344685521243536 0.370235856123706 no 2154 0.365165402106502 3061 5393182 SGTC_1269 0831-0796 3.05 µM -0.344703473724787 0.370229377439194 no 2155 0.365158653185402 3132 927758 SGTC_1221 2958-7315 257 µM -0.346268240049807 0.369664826811396 no 2156 0.364570567349284 3100 4562705 SGTC_84 0443-0269 128.823 µM -0.347269893212729 0.369303588617466 no 2157 0.364194283373088 3129 6150058 SGTC_840 0245-0196 390 µM -0.348257807334661 0.368947418299349 no 2158 0.363823288829156 3155 3827528 SGTC_922 1866-0035 480 µM -0.348573138639434 0.368833756329931 no 2159 0.363704898310592 3000 3156169 SGTC_3035 9091303 49.47 µM -0.348932355765082 0.368704289582523 no 2160 0.363570046802202 3041 25237002 SGTC_2011 4012611 177 µM -0.350820516629618 0.368024015985193 no 2161 0.362861502120128 3000 2049887 SGTC_2394 5221648 200 µM -0.3521439336114 0.367547456851282 no 2162 0.362365160808191 3148 788586 SGTC_3262 9137218 49.47 µM -0.352205210680198 0.367525396065949 no 2163 0.362342184727763 2932 17650664 SGTC_3307 9126885 69.2785 µM -0.352299661534695 0.367491393010678 no 2164 0.362306770975806 3013 24824909 SGTC_2847 9005661 71.43 µM -0.354914000181431 0.366550623607685 no 2165 0.361327009882933 3108 2991449 SGTC_3272 9137413 49.47 µM -0.355296666229365 0.366412988371435 no 2166 0.36118367636127 2995 17614870 SGTC_2650 prasterone 100 µM -0.357323124338093 0.365684409748494 no 2167 0.360424960217139 3094 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.359459279250159 0.36491691577732 no 2168 0.359625767674588 3065 229346 A bile salt which induces apoptosis. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.360207395611297 0.364648254579643 no 2169 0.35934602225886 3082 688761 SGTC_544 k015-0020 52.4 µM -0.360945214834229 0.36438335635009 no 2170 0.359070201108332 3088 3008304 SGTC_489 paxilline 115 µM -0.361576146313116 0.364156885242065 no 2171 0.358834396371075 3106 105008 A toxic potassium channel blocker. SGTC_2943 9068529 45.32 µM -0.36165720314538 0.3641277935528 no 2172 0.358804106035662 3035 3270634 SGTC_2565 isoliquiritigenin 100 µM -0.361795527789277 0.364078149976995 no 2173 0.358752417195597 3162 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2182 6325192 200 µM -0.362917867690395 0.363675435823338 no 2174 0.358333119476078 3124 736248 SGTC_855 0428-0020 25 µM -0.36563620681305 0.362700675440561 no 2175 0.357318277007617 3076 6812414 SGTC_671 0560-0003 407 µM -0.366278683307822 0.362470421555532 no 2176 0.357078567151729 3067 3238678 SGTC_1052 3253-3998 198 µM -0.366282165813225 0.36246917361358 no 2177 0.357077267972413 3008 5450317 SGTC_187 1488-2104 32.728 µM -0.366447164580709 0.362410048636899 no 2178 0.35701571562834 3119 2852859 SGTC_1682 st012968 530 nM -0.366632239929872 0.362343733405814 no 2179 0.356946678198165 3042 24207270 SGTC_383 2324-0395 7.37 µM -0.366820183448299 0.362276394694477 no 2180 0.356876575667642 3176 3146421 SGTC_1502 4534-4282 27.7 µM -0.367616171218474 0.361991245690667 no 2181 0.356579727534828 3098 3278949 SGTC_1965 Pectolinarigenin 58.4 µM -0.367659829074914 0.361975608224468 no 2182 0.356563448698647 3059 5320438 An anti-inflammatory. SGTC_2482 5981709 142.65 µM -0.370640276436441 0.360908611139114 no 2183 0.355452739557817 3080 877755 SGTC_254 nsc-64875 3.808 µM -0.371359170578088 0.360651409368268 no 2184 0.355185015941035 3212 56993 SGTC_765 1319-0117 244 µM -0.371898971834481 0.360458323830936 no 2185 0.354984035337989 3057 3487746 YGL099W LSG1 SGTC_413 propylparaben 100 µM -0.373775949970132 0.359787210742 no 2186 0.354285506933927 3046 7175 A pharmaceutical preservative. SGTC_598 3937-0236 20.2 µM -0.374056459332687 0.359686951747895 no 2187 0.354181155758011 3136 1379313 SGTC_1547 harmine 94.2 µM -0.374940431773643 0.359371067592079 no 2188 0.353852384323071 3096 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_993 3909-8757 62.7 µM -0.376141350205563 0.358942077977126 no 2189 0.353405907345165 3076 4288324 YLR208W SEC13 SGTC_2766 oltipraz 83.91 µM -0.376280587185188 0.358892351524096 no 2190 0.35335415490984 3201 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1834 st055981 52.8 µM -0.376997416550641 0.358636384250613 no 2191 0.353087762403795 3223 471719 YDL150W RPC53 SGTC_2336 9001819 198.65 µM -0.378329785647509 0.358160787203807 no 2192 0.352592810586988 3296 2989602 SGTC_1188 1403-0014 4.57 µM -0.378353325382251 0.358152386531657 no 2193 0.352584068227358 3088 9614867 SGTC_2208 7283366 200 µM -0.380554959837582 0.357366988916108 no 2194 0.351766753806819 3159 898663 SGTC_2416 tofa 880 nM -0.383633193402194 0.356269891509119 no 2195 0.350625167146078 3066 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3227 9130768 49.47 µM -0.38453814393118 0.355947588414554 no 2196 0.350289815116257 3079 17720899 SGTC_2090 5301565 104.445 µM -0.386376036698089 0.355293329806072 no 2197 0.34960909738977 3081 2056344 SGTC_1557 sumaresinolic acid 42.3 µM -0.386905375273193 0.355104973248696 no 2198 0.349413130797954 3078 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1493 4348-0038 111 µM -0.386913767426554 0.355101987321816 no 2199 0.349410024259391 3175 800424 SGTC_1181 1222-0449 220 µM -0.387578859704621 0.3548653759003 no 2200 0.349163857942483 3256 658318 SGTC_3153 9100258 49.47 µM -0.389798700234468 0.354076057068841 no 2201 0.348342702481195 3083 25236848 SGTC_9 0092-0002 10.449 µM -0.390073942589122 0.353978231484807 no 2202 0.348240935235996 3168 759368 SGTC_352 k048-0007 5.11 µM -0.391515938558266 0.353465880448999 no 2203 0.347707954877243 3184 6811911 SGTC_213 1246-0773 967 nM -0.392109824377457 0.353254945859745 no 2204 0.347488534402588 3133 6251622 SGTC_3001 9076041 71.4286 µM -0.393806261095396 0.352652658994087 no 2205 0.346862040754403 3073 16004211 SGTC_1362 1611-0397 101 µM -0.397348048087023 0.351396407778012 no 2206 0.345555410127945 3111 27816 SGTC_3280 9140961 49.47 µM -0.398087802983311 0.351134225290628 no 2207 0.345282732408342 3082 4901226 SGTC_1730 st033808 45.1 µM -0.398135156217443 0.351117444860954 no 2208 0.345265280478911 3091 1045166 SGTC_2180 6301957 200 µM -0.399371488671187 0.350679432095466 no 2209 0.344809749427409 3229 845462 SGTC_2080 5212524 12.4 µM -0.400690304977875 0.350212415337416 no 2210 0.344324074793266 3219 260183 SGTC_1587 estradiol valerate 56.1 µM -0.40150842203139 0.349922819001574 no 2211 0.344022919361141 3248 13791 A steroid. SGTC_4 0960-0234 25.671 µM -0.402308871676201 0.349639561023869 no 2212 0.343728363169039 3190 6821112 SGTC_997 3996-0078 137 µM -0.403239807709835 0.349310232630658 no 2213 0.343385908799932 3146 735687 SGTC_280 3448-3607 3.04 µM -0.403602093077168 0.349182101023617 no 2214 0.343252673140007 3220 626179 SGTC_1469 k284-2957 126 µM -0.403877663181162 0.349084650025767 no 2215 0.343151341310044 3154 23884841 SGTC_2691 st077356 60.2 µM -0.40395269681716 0.349058117293546 no 2216 0.343123752114694 3266 2839272 SGTC_1908 st060353 56.5 µM -0.405402086317717 0.3485457418972 no 2217 0.342590988827928 3317 4227716 SGTC_456 gingerol 170 µM -0.409753818091735 0.347009018731721 no 2218 0.340993273338084 3313 442793 A herb. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.409823335541839 0.346984490421577 no 2219 0.340967773402412 3299 5393153 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.410238164006418 0.34683813703129 no 2220 0.340815623847751 3144 2346 DNA damaging agent; causes G2/M arrest. SGTC_232 clozapine 119 µM -0.410241471701127 0.346836970153179 no 2221 0.340814410765304 3157 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1028 k015-0029 4.8 µM -0.411424739302066 0.346419634028943 no 2222 0.340380558296894 3102 4588309 SGTC_972 1319-0219 195 µM -0.411927145654001 0.346242492645699 no 2223 0.34019641169763 3181 23903702 SGTC_283 0987-0079 11.7 µM -0.413645974598827 0.345636712396103 no 2224 0.33956669912305 3231 411556 SGTC_3276 9139060 49.47 µM -0.416236131282436 0.344724589913325 no 2225 0.338618611577948 3144 4870619 SGTC_946 3434-1334 87.4 µM -0.417948626158976 0.34412203050941 no 2226 0.337992339492478 3239 4047976 SGTC_103 0844-0104 51.839 µM -0.420978673624202 0.34305684619948 no 2227 0.336885327419992 3249 5375804 SGTC_69 0096-0274 206.684 µM -0.421563744642993 0.342851313318523 no 2228 0.336671737059188 3412 6741392 SGTC_2971 9092186 9.93 µM -0.422624658373832 0.342478737623557 no 2229 0.336284566430527 3093 25236400 SGTC_1327 1436-0082 2.18 µM -0.424047841189134 0.341979179580664 no 2230 0.335765461693151 3164 15992205 SGTC_2231 micatex 6.853 µM -0.424483869442983 0.341826182562592 no 2231 0.335606483388216 3213 20737 An antifungal of unknown mechanism. SGTC_2412 st077135 33.4 µM -0.42466490017936 0.341762668705586 no 2232 0.335540487225963 3362 13258915 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.424958656515708 0.341659615087068 no 2233 0.335433406866446 3174 364106 SGTC_2320 7373003 200 µM -0.425695530087057 0.341401162007374 no 2234 0.33516485979463 3218 5415828 SGTC_2949 9072542 2.23 µM -0.427715682087856 0.340692989976057 no 2235 0.334429065546066 3223 16457352 SGTC_1594 piperine 70.1 µM -0.427820838689426 0.340656142270194 no 2236 0.334390782034093 3147 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2207 7258803 200 µM -0.429563309389013 0.340045788327516 no 2237 0.333756665818051 3236 3666799 SGTC_3112 9123419 49.47 µM -0.432527008439523 0.339008624564807 no 2238 0.332679213411607 3210 17015854 SGTC_326 k292-0812 17.5 µM -0.433119214937626 0.338801524329409 no 2239 0.332464082029656 3242 3579357 SGTC_833 3852-0053 558 µM -0.433141214999283 0.338793831637172 no 2240 0.332456091110182 3315 3123681 SGTC_1396 3511-0007 98.6 µM -0.433657043853459 0.338613482663504 no 2241 0.332268752245492 3233 X1396 SGTC_1433 4060-0023 7.6 µM -0.436305749333256 0.337688000716986 no 2242 0.331307455525 3283 3840627 SGTC_430 0958-0115 16.4 µM -0.437197437219322 0.337376657160781 no 2243 0.330984084085274 3153 6833180 SGTC_169 k015-0017 16.025 µM -0.437293931574354 0.337342971666464 no 2244 0.330949097871848 3383 1840002 SGTC_1270 0831-1170 17.3 µM -0.438474000845528 0.336931123394595 no 2245 0.330521356536557 3238 6764716 SGTC_2954 9074818 52.69 µM -0.439022729078592 0.336739681869243 no 2246 0.330322533594555 3304 16648742 SGTC_616 4092-0450 108 µM -0.439991028985897 0.336401962442626 no 2247 0.329971802384143 3221 787165 SGTC_2227 7312221 64.1025 µM -0.440341755856815 0.336279669989182 no 2248 0.329844801250698 3228 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2248 tofa 1.1 µM -0.44185172694299 0.335753366888122 no 2249 0.329298252229405 3101 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2814 7977482 42.97 µM -0.442018249487181 0.335695344854442 no 2250 0.32923800004064 3309 6456762 SGTC_1165 k072-0275 30.3 µM -0.44376054540983 0.335088505690276 no 2251 0.328607858240183 3316 6153523 YGL055W OLE1 SGTC_2478 5763493 32.33 µM -0.44453302959426 0.334819588118934 no 2252 0.328328627128071 3163 1365576 YLR208W SEC13 SGTC_685 1278-0033 54.9 µM -0.446027056514428 0.334299727108566 no 2253 0.327788850923193 3313 3590572 SGTC_265 mycophenolic acid 32.932 µM -0.446065879883079 0.334286222374985 no 2254 0.327774829237757 3416 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2298 7976326 193.81 µM -0.446746910082093 0.334049360480842 no 2255 0.327528903707677 3207 2235818 SGTC_670 4204-0025 119 µM -0.448622645048501 0.333397322891035 no 2256 0.326851947650106 3270 719039 SGTC_1956 st077085 54 µM -0.448807059420594 0.33333324442824 no 2257 0.326785422890438 3214 24208685 SGTC_2752 diclazuril 33.15 µM -0.449859888402407 0.332967511131255 no 2258 0.326405735888934 3277 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_535 2293-4129 48.2 µM -0.449909881809217 0.332950148294862 no 2259 0.326387710984258 3324 396118 YIL048W NEO1 SGTC_1122 capsaicin 818.572 nM -0.451565722056099 0.332375273372942 no 2260 0.32579093431579 3308 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1877 wortmannin 25 µM -0.452167113103945 0.33216657980937 no 2261 0.325574299034086 3326 312145 A covalent inhibitor of PI 3-kinase. SGTC_1511 0906-3109 28.5 µM -0.453309892848882 0.33177015802068 no 2262 0.325162805093991 3250 2882180 SGTC_981 1488-1094 54.9 µM -0.453311585648281 0.331769570940731 no 2263 0.325162195706073 3209 3449522 SGTC_3252 9135871 49.47 µM -0.454149753450001 0.331478936642557 no 2264 0.324860522598928 3328 17682838 SGTC_734 2023-0417 80 µM -0.454368923498028 0.331402956253739 no 2265 0.324781657909222 3270 3935732 SGTC_3122 9126309 49.47 µM -0.455658668968313 0.330955976667346 no 2266 0.324317723676441 3307 17591206 SGTC_258 haloperidol 50.781 µM -0.457224698530257 0.330413570699935 no 2267 0.323754773777743 3231 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_659 k018-0002 107 µM -0.459701440033885 0.329556460097435 no 2268 0.322865267880102 3327 6797879 YHR007C ERG11 SGTC_2222 6885208 172.143 µM -0.459713019256009 0.329552455045262 no 2269 0.322861111650183 3251 609514 SGTC_1660 st012960 28.1 µM -0.46258369386808 0.328560142691741 no 2270 0.321831399444036 3283 24207266 SGTC_3244 9134489 49.47 µM -0.462939316140657 0.328437297909 no 2271 0.321703932573377 3293 16584271 SGTC_2881 9058953 51.95 µM -0.464267119382453 0.327978790660857 no 2272 0.321228189191514 3186 17122249 SGTC_655 k060-0012 42 µM -0.464732757507612 0.327818061263512 no 2273 0.321061423440314 3211 5994525 SGTC_435 c-PAF 6.7 µM -0.465194835698121 0.327658592213279 no 2274 0.320895968331195 3302 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2512 diallyl trisulfide 49.23 µM -0.466852212604299 0.327086869114137 no 2275 0.320302808513821 3307 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2275 7947463 200 µM -0.466978219831878 0.327043418661409 no 2276 0.320257730446153 3315 1225414 SGTC_2344 7990960 76.95 µM -0.469393844848666 0.326210904409445 no 2277 0.319394073587793 3242 140813 SGTC_316 k060-0003 58.6 µM -0.47494015014311 0.324302720464639 no 2278 0.317414816378666 3337 6152314 SGTC_2702 st077768 96.8 µM -0.476066490083039 0.323915768701941 no 2279 0.317013504697254 3282 6484119 SGTC_2111 5486399 200 µM -0.476074139063583 0.323913141560249 no 2280 0.317010780122476 3274 689674 SGTC_161 4065-0411 162.148 µM -0.476602773807709 0.323731596350463 no 2281 0.316822503924317 3295 1906281 YLR208W SEC13 SGTC_611 3453-1652 23.7 µM -0.477975742087598 0.323260283750814 no 2282 0.316333735312512 3361 1560575 SGTC_2023 5144124 124 µM -0.480598597392572 0.322360698528079 no 2283 0.315400906256024 3212 2830192 SGTC_1891 st059073 26.2 µM -0.481254434338512 0.322135922212545 no 2284 0.315167838666284 3369 688754 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.481334185258528 0.322108593453023 no 2285 0.315139502253792 3356 5357218 A potent inhibitor of glutathione S-transferases. SGTC_714 4296-0578 26.1 µM -0.481953272651569 0.321896479525647 no 2286 0.314919570440075 3241 1589775 SGTC_543 3844-1095 191 µM -0.483704557269778 0.321296762539599 no 2287 0.314297779234889 3325 4230703 SGTC_2875 9039966 71.43 µM -0.484070629059972 0.321171462224141 no 2288 0.314167872427994 3285 6463691 SGTC_3008 9078912 71.4286 µM -0.484387078980122 0.321063163056601 no 2289 0.314055593335272 3263 16648731 SGTC_3104 9120930 49.47 µM -0.484687270384715 0.320960442132857 no 2290 0.3139490988062 3353 17014836 SGTC_3062 9077494 49.47 µM -0.485230580777075 0.320774564441299 no 2291 0.313756395899528 3343 16459633 SGTC_3019 9081971 49.47 µM -0.485957637202606 0.320525893727293 no 2292 0.313498600893363 3415 16451803 SGTC_1649 st011737 51.3 µM -0.486000526632609 0.320511227029513 no 2293 0.313483396277736 3299 1761035 SGTC_1263 0774-1208 64.8 µM -0.486538290491252 0.32032735423295 no 2294 0.313292781975171 3406 906585 SGTC_276 colchicine 750 µM -0.48717732439795 0.320108912416425 no 2295 0.313066336609067 3399 2833 A microtubule depolymerizer. SGTC_219 mitoxanthrone 164.414 µM -0.488869323622136 0.319530835266781 no 2296 0.312467107461488 3305 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2873 9040596 71.43 µM -0.489368954353079 0.319360218521232 no 2297 0.31229025568155 3359 6463863 SGTC_2074 5212007 75.395 µM -0.490897822452233 0.318838369613018 no 2298 0.311749358634408 3350 758611 SGTC_2096 5468907 200 µM -0.491383571924375 0.318672643726759 no 2299 0.311577590610432 3332 759785 SGTC_1548 st061468 90.8 µM -0.492992744471897 0.318123892438665 no 2300 0.311008856988226 3322 390799 SGTC_2898 9056270 58.44 µM -0.493240722392386 0.318039363805267 no 2301 0.310921253648637 3320 19154699 SGTC_2359 9039622 200 µM -0.495455386793197 0.317284868311128 no 2302 0.310139353166475 3283 6463596 SGTC_1259 0671-0132 43 µM -0.496542761294671 0.316914697281802 no 2303 0.309755762794225 3232 X1259 SGTC_953 1188-0045 9.7 µM -0.496712824201451 0.316856819928747 no 2304 0.309695788844775 3370 6144426 SGTC_956 1185-0240 191 µM -0.496798615282215 0.316827624429577 no 2305 0.309665535904126 3260 1416193 SGTC_1844 rapamycin 4 nM -0.497648541645944 0.316538448270956 no 2306 0.309365891780634 3298 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.497913945775505 0.316448171002212 no 2307 0.309272348702132 3335 5355888 SGTC_2598 perillyl alcohol 100 µM -0.49821907269846 0.316344395530893 no 2308 0.309164820391141 3388 10819 An apoptosis inducer. SGTC_1044 1222-0021 1.78 µM -0.500805068714357 0.315465464306442 no 2309 0.308254159015475 3320 4306703 SGTC_2441 5730946 39.09 µM -0.501027867280623 0.315389788015278 no 2310 0.308175755333968 3377 1774275 SGTC_2795 7780010 54.55 µM -0.50207516013637 0.315034165825043 no 2311 0.307807326211194 3381 953673 SGTC_2622 2-methoxyxanthone 59.94 µM -0.50321681267979 0.314646697789636 no 2312 0.307405922764259 3276 71034 A hepatoprotective. SGTC_625 k213-0058 121 µM -0.503251811037484 0.314634822838913 no 2313 0.307393621030385 3350 3655420 SGTC_2625 euphol 100 µM -0.504322590297396 0.31427159990757 no 2314 0.30701735267421 3396 6708538 A triterpene alcohol. SGTC_1837 st055472 66.5 µM -0.504372606096782 0.314254638258228 no 2315 0.306999782247995 3447 676091 SGTC_1571 st070080 73.4 µM -0.504799132761784 0.314110007987712 no 2316 0.306849962499196 3433 4315245 SGTC_2651 TUB2.036 5 µM -0.504839382639852 0.314096361192032 no 2317 0.306835826181631 3452 15992207 YFL037W TUB2 SGTC_758 0868-0029 16 µM -0.505791779607058 0.313773523438168 no 2318 0.30650141495583 3385 762687 SGTC_2184 6075246 200 µM -0.509100439642051 0.312653082836604 no 2319 0.30534091183587 3349 2267320 SGTC_1889 st059080 5.18 µM -0.509354640473703 0.312567071975576 no 2320 0.305251832289372 3420 176925 Isolated from Daphnopsis sellowiana. SGTC_1475 4092-1048 11.7 µM -0.509542511328665 0.312503510946149 no 2321 0.305186004154733 3394 2881759 SGTC_3282 9108498 15.4605 µM -0.511038345204953 0.311997635065728 no 2322 0.304662103359482 3353 16459645 SGTC_3175 9106517 49.47 µM -0.511626539035281 0.31179881088286 no 2323 0.304456203988315 3369 41468073 SGTC_2296 7971656 126.45 µM -0.512066819874294 0.311650020863207 no 2324 0.304302122633185 3342 666570 SGTC_2097 5376186 200 µM -0.512240412067396 0.311591364970594 no 2325 0.304241381590046 3378 742755 SGTC_850 0388-0143 75.9 µM -0.512324581876146 0.311562926154068 no 2326 0.304211931967912 3290 67273 SGTC_689 0833-0039 98 µM -0.513492874548404 0.31116830621155 no 2327 0.303803296921471 3353 5374726 SGTC_1522 st012842 45.6 µM -0.514364256037831 0.310874116637158 no 2328 0.303498672373054 3313 3491067 YOR116C RPO31 SGTC_33 0986-0033 35.816 µM -0.515187939179518 0.310596141730914 no 2329 0.303210848094546 3363 2848082 SGTC_1103 duloxetine 36.1 µM -0.515204329101157 0.310590611590074 no 2330 0.303205122109757 3420 60835 A selective serotonin reuptake inhibitor. SGTC_3195 9113082 49.47 µM -0.515641853892326 0.310443001711714 no 2331 0.303052286278189 3391 17018038 SGTC_1983 st071813 46.9 µM -0.516214771090974 0.310249759987413 no 2332 0.302852207406703 3361 11838595 SGTC_1749 st037932 54.2 µM -0.516759691019192 0.310066010183398 no 2333 0.302661960870319 3393 594497 SGTC_783 0848-0141 92.7 µM -0.51688566572029 0.310023537613076 no 2334 0.302617987258275 3363 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1375 2910-0797 186 µM -0.517145727614956 0.309935865351079 no 2335 0.302527217287868 3310 742508 SGTC_2485 5633444 17.78 µM -0.522567357045413 0.308110588751995 no 2336 0.300637680782148 3364 5724239 SGTC_2564 betulinic acid 100 µM -0.522666847359216 0.308077137894567 no 2337 0.300603056423572 3504 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_184 1494-0393 24.714 µM -0.522735838839339 0.308053942359778 no 2338 0.300579047246384 3274 3090647 SGTC_1738 st035555 74 µM -0.525116488570183 0.307254017448235 no 2339 0.299751107229383 3396 5331140 SGTC_1429 4049-0205 9.46 µM -0.525125471882514 0.307251000687761 no 2340 0.299747984978696 3420 22774478 SGTC_2782 7736369 71.43 µM -0.525440797867408 0.307145116724125 no 2341 0.299638399238944 3340 2950836 YOL077C BRX1 SGTC_2467 5474540 200 µM -0.525571692432069 0.307101168089814 no 2342 0.299592914575196 3334 5413519 SGTC_1929 genistein trimethyl ether 50.5 µM -0.5256298054217 0.307081657193547 no 2343 0.299572721845863 3462 136420 SGTC_1952 st077036 64.1 µM -0.526584255004895 0.306761287805535 no 2344 0.299241164110857 3403 2937007 SGTC_2770 toltrazuril 17.5 µM -0.527694638489505 0.306388763515949 no 2345 0.298855647551424 3423 68591 Kills coccidiodes. SGTC_2718 lomofungin 53.02 µM -0.52793010167018 0.306309793297822 no 2346 0.298773925565433 3440 5351222 A RNA synthesis inhibitor. SGTC_82 0054-0107 293.755 µM -0.528263394283342 0.306198028185713 no 2347 0.298658267376024 3379 3104697 SGTC_1082 camptothecin 424.86 nM -0.528660503111842 0.306064886724541 no 2348 0.298520490461351 3167 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2001 4023502 57.655 µM -0.529214475718756 0.305879195238831 no 2349 0.298328337973714 3376 108941 YCR052W RSC6 SGTC_1159 4092-0538 61.2 µM -0.530730635856832 0.305371233946537 no 2350 0.297802726584679 3407 717301 SGTC_259 usnic acid 108.925 µM -0.530866902107621 0.305325598799123 no 2351 0.297755507483443 3484 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1149 3909-7961 23.3 µM -0.533350978530837 0.304494220120472 no 2352 0.296895322443291 3378 735261 SGTC_1658 st012944 20 µM -0.537384525322656 0.303146410338545 no 2353 0.295501015113155 3406 24207260 SGTC_300 r073-0011 5.04 µM -0.537947715515792 0.302958432788929 no 2354 0.295306572626516 3462 2735780 SGTC_3241 9133421 49.47 µM -0.538093008606214 0.302909946378496 no 2355 0.295256419466348 3402 17018221 SGTC_1996 st072960 66.8 µM -0.538303241376006 0.302839794805801 no 2356 0.295183856970731 3461 1719405 SGTC_56 0957-0365 83.25 µM -0.538731498211816 0.302696914327127 no 2357 0.295036068192265 3438 6752360 SGTC_1412 3909-8563 178 µM -0.540098958088976 0.302240887321589 no 2358 0.29456439459698 3477 23767530 SGTC_2100 5377183 190 µM -0.542014748605001 0.301602519496941 no 2359 0.293904172877047 3390 2844202 SGTC_3248 9135562 49.47 µM -0.542150192263144 0.301557410764684 no 2360 0.293857522056776 3407 17650701 SGTC_2139 5578692 56.4705 µM -0.542886446268232 0.301312258709141 no 2361 0.293603994236348 3390 650991 YMR113W FOL3 SGTC_2158 5657123 3.6195 µM -0.543019558684772 0.301267945566828 no 2362 0.29355816801283 3400 2858827 SGTC_1045 1348-1485 165 µM -0.543729219598257 0.301031748899591 no 2363 0.293313911035238 3406 6810614 SGTC_918 glabranin 770.725 nM -0.543921780800189 0.300967673094047 no 2364 0.293247649973955 3393 124049 Also referred to as licorice root. SGTC_862 0452-0056 10.2 µM -0.544212459078238 0.300870959937751 no 2365 0.293147639588947 3408 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2309 7664088 163.95 µM -0.544871210787812 0.300651834956715 no 2366 0.292921048903032 3474 704922 SGTC_2918 7977171 22.06 µM -0.545965137204308 0.300288114137633 no 2367 0.292544950936307 3396 2236483 SGTC_2884 9058502 51.95 µM -0.546320420471272 0.300170028406929 no 2368 0.292422850872698 3448 6471554 SGTC_788 1182-0090 188 µM -0.546671408329698 0.300053390966966 no 2369 0.292302250279567 3512 5715185 SGTC_2056 5235370 200 µM -0.549174975900957 0.299222021073698 no 2370 0.291442687904153 3343 5511916 SGTC_2592 piperlongumine 83.33 µM -0.549462009917925 0.299126771341067 no 2371 0.291344214471176 3372 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3193 9111931 49.47 µM -0.549489289530592 0.29911771955597 no 2372 0.29133485639852 3375 17087244 SGTC_1060 3448-7350 82 µM -0.549516078343028 0.299108830746762 no 2373 0.291325666827825 3450 570178 SGTC_2895 9054447 58.44 µM -0.54966160717183 0.299060544848698 no 2374 0.291275747327165 3412 2697450 SGTC_48 0382-0018 55 µM -0.549880460266464 0.298987936908891 no 2375 0.291200683552985 3573 762596 SGTC_3322 9139058 2.11 µM -0.55011757849665 0.298909278261575 no 2376 0.291119365269304 3479 4908926 YPR165W RHO1 SGTC_644 1498-1197 63.3 µM -0.550386491523028 0.298820083782393 no 2377 0.291027155985364 3473 6741615 SGTC_1233 0325-0408 14.2 µM -0.551280109556874 0.298523770791867 no 2378 0.290720835708872 3446 12874 SGTC_3107 9121808 49.47 µM -0.552703073258326 0.29805220924039 no 2379 0.2902333742937 3428 662681 SGTC_46 0329-0187a 2.197 µM -0.553467632406813 0.297798979238184 no 2380 0.28997161924512 3408 46494817 SGTC_2925 9010536 32.5 µM -0.553609498931027 0.297752002354241 no 2381 0.289923061891915 3403 2994177 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.553827982251123 0.297679661627699 no 2382 0.289848287990169 3330 6708514 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.554072073917801 0.297598851358404 no 2383 0.289764760568087 3480 5282362 SGTC_1018 4259-0013 28.1 µM -0.555648650725862 0.297077142929598 no 2384 0.28922553305573 3448 6801262 SGTC_1875 nocodazole 6 µM -0.555952550758623 0.296976626813547 no 2385 0.289121646123465 3483 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1521 st012942 49.4 µM -0.556555159954049 0.296777357507952 no 2386 0.288915698647196 3466 24207259 SGTC_438 sphingosine 6.67 µM -0.557630408337224 0.296421949189043 no 2387 0.28854839377542 3292 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2626 ethyl orsellinate 100 µM -0.557832618143262 0.29635513336515 no 2388 0.288479343487655 3382 75653 A natural product. SGTC_1624 st003710 6.25 µM -0.557976062962816 0.29630773933743 no 2389 0.288430364897446 3458 24207033 SGTC_2528 xanthyletin 44.79 µM -0.55797643774529 0.29630761551422 no 2390 0.288430236934785 3394 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2020 4017018 200 µM -0.558641878103365 0.296087800187892 no 2391 0.288203076640551 3444 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2568 diosmetin 100 µM -0.559966538781938 0.29565044711612 no 2392 0.287751130763447 3500 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2198 6589944 200 µM -0.56086169488933 0.295355068507939 no 2393 0.287445912366034 3430 5290268 SGTC_452 diindolylmethane 8 µM -0.561471063071448 0.29515407031245 no 2394 0.287238225756804 3450 3071 Inhibits expression of several cancer promoting factors. SGTC_1239 0337-0584 35.4 µM -0.562087079368528 0.294950943297357 no 2395 0.287028345531349 3520 914301 YML130C ERO1 SGTC_1508 1080-0625 72.9 µM -0.562175875587075 0.294921668685082 no 2396 0.286998098149426 3416 767111 SGTC_2723 salbutamol 83.58 µM -0.562271881419265 0.294890018691593 no 2397 0.286965396596614 3445 9884233 β2-adrenoceptor agonist SGTC_271 rotenone 740 µM -0.562678777082627 0.294755895834413 no 2398 0.286826819197033 3496 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2393 9031399 185.94 µM -0.563513389125019 0.294480875154264 no 2399 0.286542672727058 3516 1526623 YDL150W RPC53 SGTC_3294 9122953 26.2835 µM -0.563759654534738 0.294399748611865 no 2400 0.286458856363607 3467 16459826 SGTC_133 0724-0033 378.92 µM -0.563905072427876 0.294351848837722 no 2401 0.286409368888069 3345 280309 SGTC_3186 9110464 49.47 µM -0.564044672383455 0.294305868842889 no 2402 0.28636186514497 3498 17018021 SGTC_1274 0865-0114 173 µM -0.564123375775096 0.294279947793057 no 2403 0.28633508522575 3417 870624 SGTC_3183 9108214 49.47 µM -0.564419597346107 0.294182396342612 no 2404 0.286234302392705 3406 4974831 SGTC_230 MPP+ 141.667 µM -0.565665947046092 0.293772113234345 no 2405 0.285810444146818 3441 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1488 4013-0813 75.9 µM -0.567100352897015 0.293300252305012 no 2406 0.285323001579159 3393 2910057 SGTC_527 4476-4215 268 µM -0.568422580077893 0.292865604967053 no 2407 0.284874030834922 3358 4418754 SGTC_2116 5511452 16.8835 µM -0.570120373454417 0.292307938986978 no 2408 0.284298028881776 3484 870744 SGTC_2951 9072950 58.06 µM -0.570233111813315 0.292270925855991 no 2409 0.28425980041531 3503 16488155 SGTC_1086 cerivastatin 2.18 µM -0.570638101756006 0.292137981591754 no 2410 0.284122492590002 3453 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2713 st079149 53.4 µM -0.570826687922187 0.29207608484646 no 2411 0.284058565146178 3457 3103253 SGTC_822 1487-0950 154 µM -0.57146879960801 0.29186538016442 no 2412 0.283840952019791 3497 1958375 SGTC_193 1273-0060 1.558 µM -0.573356820475917 0.291246249193627 no 2413 0.283201560129045 3417 2847393 YHR072W ERG7 SGTC_1886 st057356 49.9 µM -0.573481554756167 0.291205367189849 no 2414 0.283159342309303 3360 24207747 SGTC_2477 5967686 25.23 µM -0.574397912599345 0.290905110556943 no 2415 0.282849282571575 3416 776118 SGTC_731 3966-0296 387 µM -0.575891199782155 0.29041612573284 no 2416 0.282344362114436 3477 660956 SGTC_1124 fisetin 1.16336 µM -0.576822469349954 0.290111371507895 no 2417 0.282029694583477 3425 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_403 arphamenine a 50 µM -0.5776276605235 0.289847996803781 no 2418 0.281757764008986 3454 5487158 An arginine aminopeptidase inhibitor. SGTC_1238 0333-0287 48.8 µM -0.577863610939455 0.289770839652004 no 2419 0.281678102371259 3438 7226 SGTC_1371 2421-0008 32.7 µM -0.57960809763356 0.289200681643789 no 2420 0.281089465532337 3422 2827552 SGTC_2288 7946289 167.31 µM -0.579722350998129 0.289163358139873 no 2421 0.281050934110547 3532 1246052 SGTC_322 k048-0136 19.3 µM -0.580447675796852 0.288926466862656 no 2422 0.280806381198757 3487 6823282 SGTC_969 1313-0238 134 µM -0.580693766418041 0.288846114351643 no 2423 0.280723431852874 3432 5212874 SGTC_73 0327-0325 16.231 µM -0.582249913363643 0.288338251277939 no 2424 0.280199178645365 3526 53298 SGTC_1779 st039427 55 µM -0.582298223555883 0.288322491536587 no 2425 0.280182910930196 3539 1124498 SGTC_1282 0886-0010 32.4 µM -0.58352482548613 0.287922485841516 no 2426 0.279770024953425 3558 2836211 YNL267W PIK1 SGTC_768 0384-0033 77.3 µM -0.583735863774085 0.287853690825565 no 2427 0.279699017215745 3399 3965305 YMR134W ERG29 SGTC_2295 7971645 200 µM -0.58460910452361 0.287569111235971 no 2428 0.279405292205387 3434 2978226 YKL099C UTP11 SGTC_817 1391-0715 46 µM -0.586061881895298 0.287095961931051 no 2429 0.278916965323643 3424 1353946 SGTC_3331 9141060 1.957 µM -0.586858886097172 0.286836545472518 no 2430 0.278649242150851 3412 4906567 YPR165W RHO1 SGTC_354 2783-3500 4.88 µM -0.587199780528334 0.286725621861368 no 2431 0.278534769883415 3428 6740761 SGTC_1369 1866-0067 208 µM -0.587281157220567 0.28669914571323 no 2432 0.27850744699708 3525 3531355 SGTC_2678 equilin 100 µM -0.588723400784059 0.286230099928712 no 2433 0.278023418743423 3540 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3099 9120367 49.47 µM -0.589105049793755 0.286106041217558 no 2434 0.277895403052223 3530 24824940 SGTC_2698 st077697 67.5 µM -0.589296784088176 0.286043725768144 no 2435 0.277831100897838 3418 3154499 SGTC_2544 sphondin 68.51 µM -0.589399592652083 0.286010314674252 no 2436 0.277796624861666 3534 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_643 k048-0106 28.4 µM -0.590784012161949 0.285560581826643 no 2437 0.277332574329688 3509 6763920 SGTC_1130 3454-2858 15.9 µM -0.590920109811768 0.285516388272517 no 2438 0.277286975546633 3420 715628 YIL048W NEO1 SGTC_2221 6807166 181.081 µM -0.591525192116687 0.285319945704362 no 2439 0.277084290387404 3469 674925 SGTC_1967 st070177 51.4 µM -0.591569203111867 0.285305659857934 no 2440 0.277069550799681 3546 5729214 SGTC_1199 1638-0010 4.46 µM -0.591984774429877 0.285170783367644 no 2441 0.276930392002991 3437 3111136 SGTC_569 4130-2812 160 µM -0.59335172242907 0.284727345625772 no 2442 0.276472895433711 3445 743552 SGTC_2189 6047310 154.431 µM -0.59387842621351 0.284556570872218 no 2443 0.276296714703787 3477 711535 SGTC_3255 9139072 49.47 µM -0.594443329761971 0.284373464878641 no 2444 0.276107817515522 3520 17646060 SGTC_2966 9084041 48.03 µM -0.595129271691704 0.284151201620021 no 2445 0.275878531762382 3350 17741380 SGTC_2824 7998404 51.95 µM -0.598617494861877 0.283022212686357 no 2446 0.274713993451419 3470 837851 SGTC_2040 5100729 123 µM -0.599926403294228 0.282599131167144 no 2447 0.274277642524585 3481 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1073 triclabendazole 3.09 µM -0.602024839627754 0.281921483769051 no 2448 0.273578801527719 3530 50248 An antihelmetic and likely tubulin inhibitor. SGTC_481 bay k-8644 50 µM -0.607764892452098 0.280071860011988 no 2449 0.271671708495676 3467 2303 A calcium channel antagonist. SGTC_1286 0929-0070 131 µM -0.607830555616352 0.280050735367842 no 2450 0.271649930708086 3574 1420408 SGTC_1822 st052468 42 µM -0.608979305497312 0.279681293460938 no 2451 0.271269077994282 3463 2873678 SGTC_155 k072-0202 43.6 µM -0.609707783194939 0.279447135148888 no 2452 0.271027698903981 3501 5857737 SGTC_2865 9030313 51.95 µM -0.610653811566791 0.279143190594795 no 2453 0.270714394986869 3466 42562754 SGTC_1331 1472-0049 76.2 µM -0.610811024518788 0.279092696037684 no 2454 0.270662347022176 3487 24051409 SGTC_3174 9107204 49.47 µM -0.612084480026946 0.278683844068443 no 2455 0.270240932650766 3559 3938802 SGTC_3290 9121031 71.43 µM -0.613376341230363 0.278269381008534 no 2456 0.269813762934524 3467 17014854 SGTC_2242 6630449 61.2675 µM -0.61642430256726 0.277292707388963 no 2457 0.268807258898418 3527 691249 YDR170C SEC7 SGTC_874 0599-0792 117 µM -0.617882674214265 0.276825987724968 no 2458 0.268326340320151 3594 765305 SGTC_279 1273-0055 2.93 µM -0.618734384817359 0.276553594624084 no 2459 0.268045677076162 3550 2847562 SGTC_3344 9148862 3.898 µM -0.619101359355119 0.276436269768383 no 2460 0.267924793939838 3598 4905352 SGTC_888 0916-0002 6.97 µM -0.619447322072006 0.276325684926722 no 2461 0.267810857343207 3590 2802138 YIL048W NEO1 SGTC_2252 omeprazole 400 µM -0.62006593032044 0.276128004740331 no 2462 0.267607190708554 3496 4594 A proton pump inhibitor. SGTC_79 0052-0007 94.094 µM -0.62396942848202 0.274882220676479 no 2463 0.266323831276081 3608 2801472 SGTC_2754 granisetron 64.02 µM -0.623985220837087 0.274877186247981 no 2464 0.266318645530732 3573 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.625452695415205 0.274409569951732 no 2465 0.265836993101835 3549 140250 A respiratory chain inhibitor. SGTC_245 methotrexate 289.6 µM -0.626348068305222 0.274124449007961 no 2466 0.265543332093014 3541 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1807 st050092 58.9 µM -0.628202941700765 0.273534252472206 no 2467 0.264935501737444 3496 5008496 SGTC_585 0kpi-0023 191 µM -0.62940700024259 0.2731514736626 no 2468 0.264541318121135 3523 64601 SGTC_787 4152-0075 138 µM -0.630240908923474 0.272886523805041 no 2469 0.264268488843355 3529 9566539 SGTC_2091 4-phenylthiadiazole 200 µM -0.630574076158684 0.272780705398944 no 2470 0.264159526839558 3541 270010 SGTC_3310 9130229 44.1445 µM -0.631347471992643 0.272535142957545 no 2471 0.263906676771906 3554 7761258 SGTC_1563 conessine 56.1 µM -0.633913670653323 0.271721131237121 no 2472 0.263068581700101 3624 441082 An anti-amoebic, histamine inhibitor. SGTC_3147 9097027 49.47 µM -0.634240417702641 0.271617572274213 no 2473 0.262961967049537 3557 25236841 SGTC_1622 st003707 19.4 µM -0.634945536863205 0.271394159324806 no 2474 0.262731968238013 3580 10140899 SGTC_2106 5357045 167.29 µM -0.635804334334195 0.271122178013647 no 2475 0.262451981030336 3546 668842 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.636385460105952 0.27093821251806 no 2476 0.262262607709882 3588 5377381 SGTC_2311 7694451 200 µM -0.636700334350674 0.270838559608968 no 2477 0.262160027875202 3503 2163142 SGTC_361 000s-0510 1.45 µM -0.63673376249832 0.270827981182973 no 2478 0.262149138849607 3551 660 SGTC_1782 st039423 80.636 µM -0.636939735346016 0.270762805079494 no 2479 0.262082049500741 3503 2068169 SGTC_2520 obtusaquinone 4.71 µM -0.636965649733931 0.270754605529825 no 2480 0.262073609305569 3639 5967872 SGTC_1114 scopoletin 1.73284 µM -0.637610356475801 0.270550654326625 no 2481 0.261863676184962 3597 5280460 A coumarin with genotoxic properties. SGTC_3156 9099931 49.47 µM -0.640079724611747 0.269770187153593 no 2482 0.261060384891232 3570 18111053 SGTC_3127 9126946 49.47 µM -0.640354133303965 0.26968352734523 no 2483 0.260971197365888 3504 27243249 SGTC_565 1418-0001 44.5 µM -0.640598166831228 0.269606471900918 no 2484 0.260891895453945 3615 2862145 SGTC_2877 9040724 71.43 µM -0.642284639461228 0.269074257039873 no 2485 0.260344192937851 3588 6463895 SGTC_275 trichlorophene 5.69 µM -0.643224091737821 0.268778014724113 no 2486 0.260039351465431 3592 62616 SGTC_1619 st003326 88.7 µM -0.646401563206299 0.267777261956581 no 2487 0.259009664154433 3566 2849032 SGTC_215 1287-0124 461.5 µM -0.646433000187399 0.267767370185915 no 2488 0.258999487271615 3578 5560863 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.647072478974156 0.267566195623439 no 2489 0.258792517996539 3721 16725076 SGTC_340 k038-0059 454 µM -0.648083304223888 0.267248354135703 no 2490 0.258465535960286 3576 23733424 SGTC_846 0335-0850 148 µM -0.648717897747991 0.267048911460247 no 2491 0.258260366871645 3580 6819598 SGTC_2923 7992654 58.14 µM -0.649734471707285 0.266729575104258 no 2492 0.257931876505197 3604 2985126 SGTC_3178 9107506 49.47 µM -0.649888917252861 0.266681076023038 no 2493 0.257881988757999 3626 8897194 SGTC_1625 st003711 30.1 µM -0.650996551936273 0.266333386605633 no 2494 0.257524356349624 3655 24207034 YER133W GLC7 SGTC_3083 9117465 49.47 µM -0.652004953042173 0.266017046478266 no 2495 0.257198988587234 3594 16420915 SGTC_3082 9117008 49.47 µM -0.653216048209136 0.265637371995095 no 2496 0.256808502818526 3576 41448529 SGTC_1390 3413-2614 145 µM -0.653977685503038 0.265398741955951 no 2497 0.256563091054111 3608 3421432 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.655171578275108 0.265024900170601 no 2498 0.256178645590094 3574 75037 A free radical scavenger. SGTC_1797 st048695 56.8 µM -0.656188812854149 0.264706586311084 no 2499 0.255851322996257 3586 592262 YIL048W NEO1 SGTC_208 k072-0098 12.366 µM -0.656593778737445 0.264579918191387 no 2500 0.25572107510102 3614 5948901 SGTC_429 1112-0049 25.5 µM -0.657419509794963 0.26432173571084 no 2501 0.255455605135618 3568 2836170 SGTC_1374 2889-5571 141 µM -0.657636854655365 0.264253799521206 no 2502 0.255385753386882 3596 2853281 SGTC_1480 1070-0044 41.2 µM -0.658617597480604 0.263947356172682 no 2503 0.255070679872462 3595 3124987 SGTC_3275 9138069 49.47 µM -0.659347635392813 0.263719365848239 no 2504 0.254836279914777 3614 17617007 SGTC_830 4076-0286 57.8 µM -0.659591109108862 0.263643351520257 no 2505 0.254758130659039 3655 6866659 SGTC_1472 k841-0093 193 µM -0.661554792123453 0.263030683787325 no 2506 0.254128294234102 3666 X1472 SGTC_697 0508-1955 564 µM -0.661587639972822 0.263020441472516 no 2507 0.254117765485221 3613 6243113 SGTC_2077 5212015 200 µM -0.661912091865355 0.262919284814061 no 2508 0.254013780938809 3536 780900 SGTC_507 nimesulide 162 µM -0.662526877313522 0.262727663378916 no 2509 0.253816807778526 3657 4495 A COX2 inhibitor. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.662848965568915 0.262627300762689 no 2510 0.253713644865679 3579 688662 SGTC_1722 st034304 3.6505 µM -0.66542806115029 0.261824363350965 no 2511 0.252888370912207 3632 4036148 YLR033W RSC58 SGTC_1694 st024011 44.9 µM -0.66613669028289 0.261603969969207 no 2512 0.252661867349606 3671 2787533 SGTC_2307 7538926 6.34 µM -0.667411514117487 0.261207722137755 no 2513 0.252254656602898 3620 96582 SGTC_1329 1447-1697 50.6 µM -0.66836313528684 0.260912135122168 no 2514 0.25195091063174 3608 2840515 SGTC_2687 chenodiol 100 µM -0.66896987031174 0.260723764476392 no 2515 0.251757348960562 3631 5702181 A cholesterol synthesis inhibitor. SGTC_2859 9028643 45.46 µM -0.669150796803299 0.260667606486415 no 2516 0.251699644676042 3595 17151580 SGTC_3085 9117376 49.47 µM -0.670064678884678 0.260384040706436 no 2517 0.251408279979382 3649 16480349 SGTC_2390 9097792 176.6 µM -0.67055568628523 0.260231753112272 no 2518 0.251251810215245 3603 4497149 SGTC_1628 st004252 77.7 µM -0.670953704316615 0.260108340175105 no 2519 0.25112501125503 3610 692968 SGTC_2725 haloperidol 53.21 µM -0.672621884236931 0.259591418212937 no 2520 0.250593937757069 3593 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3181 9108277 49.47 µM -0.67287856898456 0.259511925951962 no 2521 0.250512273721765 3593 17097298 SGTC_3110 9122132 49.47 µM -0.673774543930807 0.259234551555481 no 2522 0.250227330604016 3707 918317 SGTC_1572 epiandrosterone 68.9 µM -0.674490759476595 0.259012937015799 no 2523 0.249999679274407 3595 441302 A steroid. SGTC_1392 3455-1037 33.9 µM -0.674535915371867 0.258998967965821 no 2524 0.249985330017064 3640 981132 SGTC_1287 0971-0001 34.6 µM -0.67520190199101 0.258792989177428 no 2525 0.249773749205404 3643 4665869 SGTC_2483 5729050 27.16 µM -0.675364172975486 0.258742814258428 no 2526 0.249722210888051 3675 2865180 SGTC_648 0375-0473 33.3 µM -0.678220161665388 0.25786055454535 no 2527 0.248816055476676 3645 1713139 SGTC_306 1672-3436 11.6 µM -0.681562237502744 0.256830120603242 no 2528 0.247757899956618 3664 6797378 SGTC_2967 9089538 49.85 µM -0.683871643978071 0.25611933500559 no 2529 0.247028110577338 3649 728216 SGTC_83 0170-0301 39.027 µM -0.683939672250402 0.25609841293382 no 2530 0.247006630596438 3600 3089716 SGTC_3209 9113616 49.47 µM -0.685202484320423 0.255710197428859 no 2531 0.246608078203225 3675 16649353 SGTC_392 N-ethylmaleimide 8.33 µM -0.685794175246697 0.255528404724245 no 2532 0.246421454950458 3622 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3066 9117245 49.47 µM -0.687769475030794 0.254921997616027 no 2533 0.245798980740021 3714 17176980 SGTC_2007 4011539 71.82 µM -0.68836891817932 0.254738120642994 no 2534 0.245610245914984 3669 45595301 SGTC_754 3474-0146 171 µM -0.68899087805781 0.254547410178006 no 2535 0.245414503997523 3614 24762078 SGTC_34 0469-0683 81.75 µM -0.68972808257389 0.254321459359152 no 2536 0.245182601141456 3648 3690923 SGTC_554 4483-2211 187 µM -0.689775295627224 0.254306992292982 no 2537 0.245167753319595 3666 747107 SGTC_2067 5224629 34.075 µM -0.69085504514055 0.253976252269423 no 2538 0.244828319740261 3645 2835000 SGTC_1655 st012546 55.1 µM -0.691299372934142 0.253840215001119 no 2539 0.244688712902256 3626 720985 YLR208W SEC13 SGTC_2143 5623677 140.463 µM -0.692015244024644 0.253621121374951 no 2540 0.244463877936168 3620 5375313 SGTC_2381 9035592 200 µM -0.693435065431252 0.253186876534028 no 2541 0.244018281484382 3640 4749657 SGTC_2840 9008771 71.43 µM -0.693909958848137 0.253041720215196 no 2542 0.243869338872258 3633 2992978 SGTC_1032 k061-1018 98.7 µM -0.694896386754178 0.252740347821247 no 2543 0.243560118622664 3746 4005393 SGTC_231 b-estradiol 524 µM -0.695595654455823 0.252526822840321 no 2544 0.243341044180933 3616 450 A steroid. SGTC_2093 5331342 194.4 µM -0.695923835536835 0.252426643844455 no 2545 0.243238264653326 3673 33839 SGTC_2848 9016370 25.97 µM -0.696877753712803 0.252135574282439 no 2546 0.242939650491249 3675 7894410 SGTC_1880 MG-132 525 µM -0.696979207311063 0.252104628110536 no 2547 0.242907903170146 3611 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2262 9014885 67.46 µM -0.697202851589972 0.252036417456434 no 2548 0.242837927314511 3609 6457424 SGTC_2956 9076196 2.52 µM -0.697670510744886 0.251893814669307 no 2549 0.242691637127828 3707 16423868 SGTC_2130 NSC 7 2.4545 µM -0.698353267162748 0.251685699011337 no 2550 0.24247814727184 3689 21448 SGTC_2872 9044037 25.97 µM -0.699598063412729 0.251306497980903 no 2551 0.242089176157636 3670 6465195 SGTC_757 1066-0008 322 µM -0.699865276427721 0.251225136546354 no 2552 0.242005722172011 3692 6842497 SGTC_1213 1315-0166 115 µM -0.70042248320069 0.251055522179744 no 2553 0.241831749691073 3665 768401 SGTC_786 4544-0069 423 µM -0.702961111038518 0.250283528469339 no 2554 0.241039992605904 3709 748821 YLR208W SEC13 SGTC_721 1187-1332 279 µM -0.703833361190839 0.250018569056493 no 2555 0.240768277566035 3610 25730 SGTC_1325 1431-0015 227 µM -0.70383486652228 0.250018111917576 no 2556 0.240767808783672 3643 1103340 SGTC_621 3584-0052 32.1 µM -0.703956264165312 0.249981247352366 no 2557 0.24073000540632 3688 2273927 SGTC_926 2268-1401 59.4 µM -0.705506250818916 0.249510819820509 no 2558 0.240247621664059 3681 2931578 SGTC_3060 1327-0027 12.5 µM -0.706705636040633 0.249147124394897 no 2559 0.239874713185281 3624 16000455 YPR107C YTH1 SGTC_1304 1165-0502 251 µM -0.706771152986203 0.249127265497613 no 2560 0.23985435199386 3700 767425 SGTC_1696 st025591 34.7925 µM -0.708497908086695 0.248604170953752 no 2561 0.239318055401417 3678 2787147 SGTC_1394 3474-0001 65.7 µM -0.70919522709876 0.248393094588832 no 2562 0.239101667480385 3663 5017666 YIL048W NEO1 SGTC_2174 5790901 200 µM -0.710521466695307 0.247991909604531 no 2563 0.238690411912983 3708 786020 SGTC_3061 glucosamine 200 µM -0.712238008474675 0.247473172731915 no 2564 0.238158702144192 3619 91431 and experimental redox chemotherapeutic SGTC_2043 5101342 149 µM -0.712740438584499 0.247321448720688 no 2565 0.238003194084651 3705 678451 SGTC_2846 9008642 19.48 µM -0.712804510821752 0.247302103740947 no 2566 0.23798336697213 3696 2992898 SGTC_3329 9141233 27.5565 µM -0.713769899897926 0.247010727045716 no 2567 0.237684737572982 3696 4909101 YNL103W MET4 SGTC_2131 toluylene red 5.2905 µM -0.713855199002229 0.246984990642922 no 2568 0.237658361395289 3701 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1090 efavirenz 20.7 µM -0.713989200147982 0.246944562782405 no 2569 0.237616928822111 3748 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1080 nisoldipine 24.4 µM -0.715973053922658 0.24634645284228 no 2570 0.237003993779786 3698 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_944 3370-0224 231 µM -0.717768711561587 0.245805752176169 no 2571 0.236449954228333 3732 4580514 SGTC_39 0986-0283 58.349 µM -0.71783165020916 0.245786811925728 no 2572 0.236430547820334 3738 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1546 5-methoxyflavanone 78.7 µM -0.717938927022237 0.24575453071019 no 2573 0.236397472269806 3723 147795 SGTC_2680 butyl paraben 22.24 µM -0.719054714091691 0.24541890850908 no 2574 0.236053604247428 3748 7184 An antifungal and steroid mimetic. SGTC_3088 9117578 49.47 µM -0.720234313021833 0.245064360089501 no 2575 0.235690370305113 3758 678341 SGTC_416 estradiol valerate 100 µM -0.721244365508536 0.244760990818967 no 2576 0.235379589945246 3726 13791 A steroid. SGTC_952 1185-0122 232 µM -0.721457072917789 0.244697129927847 no 2577 0.235314171412626 3679 678600 SGTC_60 0986-0278 202 µM -0.723790630163164 0.243997118296445 no 2578 0.234597141298393 3549 3110598 SGTC_3102 9121669 49.47 µM -0.725039436517715 0.243622950334207 no 2579 0.23421391858267 3741 41905072 SGTC_173 1273-0061 2.693 µM -0.725149736418329 0.243589917123361 no 2580 0.234180087384076 3698 2847414 YPL266W DIM1 SGTC_440 fluspirilene 35.1 µM -0.730261270429925 0.242061744043404 no 2581 0.232615248511432 3809 3396 An atypical antipsychotic. SGTC_1000 4048-0884 8.67 µM -0.730360360231295 0.242032171053335 no 2582 0.232584970824189 3703 13040088 SGTC_1506 4226-2149 212 µM -0.73129605456359 0.241753013123979 no 2583 0.232299169936772 3755 991114 SGTC_393 acivicin 6.25 µM -0.732094101718225 0.241515059425007 no 2584 0.23205556682801 3626 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_562 3772-2733 112 µM -0.732643411953282 0.241351345543364 no 2585 0.231887973088087 3745 2876874 YIL048W NEO1 SGTC_1330 1469-0054 61.8 µM -0.732849089109894 0.241290061993121 no 2586 0.231825238642344 3739 7102664 SGTC_2332 7982454 138.89 µM -0.733035923114394 0.241234400277288 no 2587 0.231768259820417 3705 2981748 SGTC_3005 9076496 71.4286 µM -0.733182272869306 0.241190804531683 no 2588 0.231723632942113 3743 21368410 SGTC_2703 st077852 53.4 µM -0.735782765279434 0.240416865219521 no 2589 0.230931455708808 3706 6281836 SGTC_2451 5856223 45.7 µM -0.736620944221936 0.240167701164523 no 2590 0.230676447310078 3709 2179896 SGTC_432 NS 1619 61.3 µM -0.737087004300755 0.240029217173777 no 2591 0.230534720813019 3795 4552 A K+/calcium channel activator. SGTC_2156 5649887 115 µM -0.738574467849664 0.239587527132274 no 2592 0.230082716392619 3784 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1588 farnesol 29.9 µM -0.739063046694509 0.239442544530012 no 2593 0.229934357283963 3748 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.739136005089895 0.239420898711633 no 2594 0.229912207743171 3734 616764 SGTC_2570 licareol 100 µM -0.739435682626827 0.239331999448027 no 2595 0.229821240752093 3748 443158 SGTC_3092 9117248 49.47 µM -0.740192184349451 0.239107663640692 no 2596 0.229591694638907 3803 17141857 SGTC_1229 0139-0193 12.2 µM -0.740331785184515 0.239066278459914 no 2597 0.229549349453217 3756 3090752 SGTC_1454 4239-0054 42.6 µM -0.740517075358971 0.239011354554528 no 2598 0.229493152058162 3855 1340767 SGTC_127 0180-0333 59.125 µM -0.741526070837384 0.238712388171664 no 2599 0.229187265135199 3685 771601 SGTC_2419 paclitaxel 166.5 µM -0.742573289266073 0.238402312798301 no 2600 0.228870032491999 3693 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1977 st070720 65.3 µM -0.743672780871748 0.238076997122969 no 2601 0.228537230166398 3767 682188 SGTC_339 3091-4833 71.4 µM -0.743790515806512 0.23804217634072 no 2602 0.228501609397408 3677 3240077 SGTC_2176 5809774 33.9695 µM -0.744203820473303 0.23791996121751 no 2603 0.228376588539893 3741 2870539 SGTC_682 0kpi-0099 17 µM -0.744294951589721 0.237893018170579 no 2604 0.228349027389089 3764 1714895 YML126C ERG13 SGTC_3028 9087778 49.47 µM -0.744382421819484 0.237867159043749 no 2605 0.228322575173219 3720 17217395 SGTC_2797 7859098 81.82 µM -0.744792312082353 0.237746002304311 no 2606 0.228198641595008 3774 972681 SGTC_552 k242-0005 476 µM -0.744937042299585 0.237703230548875 no 2607 0.228154890300053 3777 4088318 SGTC_522 1273-0010 11.6 µM -0.74542417751944 0.237559299728849 no 2608 0.228007666167757 3803 5705015 SGTC_1216 1165-0504 9.65 µM -0.745536941401698 0.237525988903052 no 2609 0.227973593793075 3725 6304004 SGTC_1794 st048918 76.9 µM -0.746125533460269 0.23735215847287 no 2610 0.227795793195027 3664 672303 SGTC_596 1155-0152 116 µM -0.747621210225643 0.236910750803509 no 2611 0.227344333735559 3742 280313 SGTC_2081 5214970 32.255 µM -0.75007999771885 0.236186089376459 no 2612 0.226603262791935 3687 2063512 SGTC_1468 k284-1086 134 µM -0.750093225731322 0.236182194080429 no 2613 0.226599279600994 3756 15996457 SGTC_1905 st060207 84.5 µM -0.750571475957811 0.23604138594306 no 2614 0.226455296458578 3680 1948547 SGTC_1861 st057647 17.4 µM -0.750940477320955 0.235932774865873 no 2615 0.226344239352934 3781 688668 SGTC_1170 0310-0127 64.8 µM -0.751402815703354 0.235796730053954 no 2616 0.226205134345919 3767 774975 SGTC_867 0518-0118 155 µM -0.75255450348336 0.235458029720348 no 2617 0.225858833023275 3775 6848158 SGTC_444 curcumin 90.4 µM -0.752725472766766 0.235407772189371 no 2618 0.225807449790863 3708 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2448 5185112 27.17 µM -0.753251091057179 0.235253300366087 no 2619 0.225649521503722 3754 5718189 SGTC_3018 9082602 49.47 µM -0.7537064026693 0.235119535936626 no 2620 0.225512768227547 3740 17332089 SGTC_647 0140-0236 81 µM -0.753755910120937 0.235104993845647 no 2621 0.225497901445445 3763 990837 SGTC_924 2046-0044 21.3 µM -0.753940269296099 0.235050845399872 no 2622 0.225442544402837 3754 3623589 SGTC_2420 aureobasidin a 50 nM -0.754799152281781 0.234798672256391 no 2623 0.225184751305619 3812 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2094 5332512 191.667 µM -0.755084774254348 0.234714845097751 no 2624 0.225099059093849 3812 755774 SGTC_23 0213-0011 39.996 µM -0.755140775398378 0.234698411269129 no 2625 0.225082259815417 3779 627608 SGTC_1716 st033144 30.6155 µM -0.757169741686012 0.234103429788311 no 2626 0.224474087819333 3753 674617 SGTC_1653 st012112 65 µM -0.757686541327156 0.233952015158193 no 2627 0.22431932898072 3770 720429 SGTC_2978 9011784 42.97 µM -0.759291524463213 0.233482124967829 no 2628 0.223839093224036 3811 2994934 SGTC_3078 9116413 49.47 µM -0.761086655580363 0.232957186003489 no 2629 0.223302655204568 3703 17177322 SGTC_2349 9023730 187.07 µM -0.761483983435861 0.232841086569918 no 2630 0.223184020914607 3744 4126287 SGTC_1816 st051957 91.6 µM -0.762433197387722 0.232563855872332 no 2631 0.22290074957732 3765 674121 SGTC_246 cycloheximide 667 µM -0.762814702695414 0.232452483842011 no 2632 0.222786955715379 3655 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1686 st019653 115.5 µM -0.76384354316557 0.232152284546818 no 2633 0.222480242406683 3753 97252 SGTC_1695 st026914 34.495 µM -0.76426127837642 0.232030457672206 no 2634 0.222355777825679 3732 3289191 SGTC_652 0437-0092 114 µM -0.764301451183087 0.232018743688019 no 2635 0.222343810395834 3738 3091274 SGTC_2669 eugenol 100 µM -0.764604274737816 0.23193045399799 no 2636 0.222253611455086 3740 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2695 st077686 51.995 µM -0.765208027159049 0.231754482873292 no 2637 0.222073840248854 3828 2876092 SGTC_2030 5175110 200 µM -0.765452085349789 0.231683370207205 no 2638 0.222001193902204 3820 2831986 SGTC_5 0352-0601 109.883 µM -0.767250760336981 0.231159654921517 no 2639 0.221466219064156 3694 762456 SGTC_1784 st039334 36.3 µM -0.768117238148298 0.230907600893373 no 2640 0.221208768274379 3827 3496984 SGTC_2767 sibutramine 71.45 µM -0.769097095699761 0.230622750252635 no 2641 0.220917836098522 3798 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2253 7938677 135.83 µM -0.769158743227616 0.23060483550309 no 2642 0.22089953948997 3822 2301972 SGTC_2689 tacrolimus 100 µM -0.769850765903622 0.230403787327805 no 2643 0.220694210935916 3801 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2681 menadione 3.18 µM -0.770562842640718 0.230197015330065 no 2644 0.220483046345249 3817 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1427 4048-4900 550 nM -0.7709071590322 0.230097070386554 no 2645 0.220380981717157 3784 24132586 SGTC_1173 0443-0020 122 µM -0.771978127119293 0.229786355036677 no 2646 0.220063691189758 3794 5331295 SGTC_601 0986-0029 62.9 µM -0.772514365770431 0.229630866743067 no 2647 0.219904920868735 3769 24747981 SGTC_3106 9121286 49.47 µM -0.772771206787939 0.229556413745721 no 2648 0.219828898295484 3802 15943471 SGTC_1621 st003705 32.4 µM -0.773038197119055 0.229479033007625 no 2649 0.219749887612486 3825 24207032 SGTC_1611 st001856 99.4 µM -0.773100588017981 0.229460952610544 no 2650 0.219731426569301 3772 647478 SGTC_713 1488-1073 324 µM -0.7742576752809 0.229125782452894 no 2651 0.219389213726421 3754 3312542 SGTC_1723 st034307 2.5525 µM -0.774326142942493 0.229105958229969 no 2652 0.219368973763211 3850 867466 SGTC_426 0988-0037 14.6 µM -0.776201782396383 0.228563257275021 no 2653 0.218814926927181 3767 5383008 SGTC_474 dl-dihydrosphingosine 5 µM -0.776260678944962 0.2285462277406 no 2654 0.218797542470793 3797 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3215 9129942 49.47 µM -0.77758172795429 0.228164442777284 no 2655 0.218407818171676 3737 17682944 SGTC_1554 st069299 38.7 µM -0.778072411232318 0.228022726025616 no 2656 0.21826316299007 3751 24207999 SGTC_2917 7979103 53.79 µM -0.779226642588474 0.227689561833145 no 2657 0.217923109200072 3852 2980565 SGTC_2014 4013930 200 µM -0.78351472365152 0.226454227648075 no 2658 0.216662455464198 3772 64556 SGTC_2196 6573537 42.6665 µM -0.78411641193343 0.226281193239223 no 2659 0.216485903094261 3814 2903087 SGTC_1676 st018489 23.4 µM -0.785516861586729 0.225878739228763 no 2660 0.216075294061323 3863 3696235 SGTC_1706 st031321 9.9705 µM -0.785533745120504 0.225873889796358 no 2661 0.216070346596542 3839 6103185 SGTC_182 3448-4371 550.524 µM -0.785989273252457 0.225743071351079 no 2662 0.215936885721476 3779 3491403 SGTC_2989 9073649 71.4286 µM -0.786263624161708 0.22566430401536 no 2663 0.21585652929688 3750 21367202 SGTC_1912 st060209 90.8 µM -0.786303544802352 0.225652843922425 no 2664 0.215844838124862 3840 688787 SGTC_2120 5538279 151.968 µM -0.788330815476661 0.225071304667092 no 2665 0.215251613629739 3799 2058197 SGTC_3324 9138759 60.749 µM -0.790490059172589 0.224452842863068 no 2666 0.214620812735381 3863 45595710 SGTC_483 fpl-64176 144 µM -0.790738670262061 0.22438169634865 no 2667 0.214548252596868 3842 3423 SGTC_2133 5320837 200 µM -0.790930059588179 0.224326934047886 no 2668 0.214492403035044 3807 2841355 SGTC_925 2064-1272 59.6 µM -0.791103940132477 0.224277188119922 no 2669 0.214441670061969 3809 6815817 SGTC_399 oxolinic acid 75 µM -0.791380050146509 0.224198207972829 no 2670 0.214361124025221 3786 4628 A DNA gyrase inhibitor. SGTC_2170 morpholine 200 µM -0.79142980371811 0.224183977845518 no 2671 0.214346611924417 3845 121171 Reacts with secondary amines. SGTC_3338 9144300 39.5675 µM -0.791819150457171 0.224072637650489 no 2672 0.214233067165063 3847 4901274 SGTC_760 0568-0725 82.9 µM -0.791943168233401 0.22403717929563 no 2673 0.214196907347389 3862 3916171 SGTC_2405 ticlatone 3.52 µM -0.792754707086333 0.223805228083212 no 2674 0.213960374922702 3717 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2991 9074669 71.4286 µM -0.79658227344063 0.222713088290802 no 2675 0.212846837938271 3790 17333109 SGTC_20 0481-0013 4.944 µM -0.796877503753809 0.222628975030306 no 2676 0.212761088633177 3849 182045 SGTC_3318 9139014 38.6185 µM -0.797362893248194 0.222490723408271 no 2677 0.212620151657755 3799 16643984 SGTC_2388 9080168 200 µM -0.797750988506363 0.222380218959848 no 2678 0.212507504126915 3800 15943073 SGTC_3040 9091894 49.47 µM -0.797796299875889 0.222367319251371 no 2679 0.212494354438587 3730 25236966 SGTC_1127 asiatic acid 681.4 nM -0.797801102101996 0.22236595212908 no 2680 0.212492960825573 3807 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1451 4152-0210 104 µM -0.798631528634854 0.222129614167441 no 2681 0.212252050137207 3808 659563 SGTC_327 1273-0057 3.96 µM -0.798991158841965 0.222027308534679 no 2682 0.212147769261733 3738 3108138 SGTC_171 k064-0041 9.68 µM -0.799023322443876 0.222018160119954 no 2683 0.212138444339562 3844 53325 SGTC_451 chloral hydrate 100 µM -0.799288009058669 0.221942882480055 no 2684 0.212061715079927 3901 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2433 5607874 27.82 µM -0.799643229024278 0.221841879801572 no 2685 0.211958766869961 3834 2252428 SGTC_3150 9097574 49.47 µM -0.800248717562362 0.221669776685445 no 2686 0.211783354375002 3817 17217476 SGTC_3256 9138902 49.47 µM -0.802480601438068 0.221036048813019 no 2687 0.211137502598758 3870 17228773 SGTC_2832 7992762 51.95 µM -0.802599590018327 0.221002291972734 no 2688 0.211103102697697 3793 2985177 SGTC_2719 novobiocin 32.65 µM -0.803379810600249 0.220781017955071 no 2689 0.210877620343175 3812 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1946 st076057 65.1 µM -0.806553085274088 0.219882371583489 no 2690 0.209962006065494 3719 953009 SGTC_2078 5212016 200 µM -0.808374189988324 0.219367598569382 no 2691 0.209437602664464 3740 1899708 SGTC_3031 9088762 49.47 µM -0.8085737265328 0.219311237553756 no 2692 0.209380191212471 3806 205253 SGTC_2202 7226349 200 µM -0.809194152485158 0.219136045454237 no 2693 0.209201738953351 3805 844334 SGTC_2426 5582046 32.21 µM -0.809265959883329 0.219115774115354 no 2694 0.209181090873407 3832 2251934 SGTC_615 k087-0205 167 µM -0.809422082860008 0.219071704079781 no 2695 0.209136202150513 3834 9642773 SGTC_3345 9148410 3.559 µM -0.809897244117663 0.21893760801757 no 2696 0.208999617945027 3808 4903596 SGTC_564 3555-0129 330 µM -0.811205182381423 0.218568736502905 no 2697 0.208623925012982 3726 563260 SGTC_1773 st048542 73.5835 µM -0.812438790514109 0.218221156078368 no 2698 0.208269947789093 3796 3237138 SGTC_816 0325-0417 81.3 µM -0.817849180032779 0.216700495944156 no 2699 0.206721655941863 3889 68101 SGTC_2160 5660466 132.927 µM -0.819847716419575 0.216140335126189 no 2700 0.206151462653111 3783 2859134 SGTC_2640 pentamidine 10.38 µM -0.820777387407467 0.215880047837986 no 2701 0.205886540542464 3873 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1910 st062352 60.4 µM -0.821923187255444 0.215559499280083 no 2702 0.205560307646518 3809 2245730 SGTC_1955 wogonin 32.4 µM -0.822087776626073 0.215513476499795 no 2703 0.205513470872245 3951 5281703 A flavanone. SGTC_1413 3910-0535 34.4 µM -0.822155172966817 0.215494632656699 no 2704 0.205494293897413 3868 2876951 SGTC_1426 4048-4480 71.7 µM -0.82261402103623 0.215366365323616 no 2705 0.205363761375853 3834 14224343 SGTC_1596 piperlongumine 63 µM -0.82305271983838 0.215243771989958 no 2706 0.20523900695594 3897 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2828 7998861 71.43 µM -0.823390216797981 0.215149486839564 no 2707 0.205143062333639 3771 2988188 SGTC_2380 9035439 200 µM -0.823991268792696 0.214981632774653 no 2708 0.204972259531611 3983 6462575 SGTC_745 0469-0705 296 µM -0.824442903217304 0.214855556182225 no 2709 0.20484397282954 3938 3486736 SGTC_2218 6965428 192.983 µM -0.825025349534794 0.214693026056429 no 2710 0.204678599537422 3791 675684 SGTC_3049 9092223 49.47 µM -0.825220535014948 0.214638576044973 no 2711 0.204623198527784 3850 8623917 SGTC_2809 7964133 12.99 µM -0.82941543563706 0.213470284837441 no 2712 0.203434685034397 3902 1253665 SGTC_2909 7941780 10.49 µM -0.830851850663181 0.213071092764261 no 2713 0.203028663487008 3817 1243215 SGTC_411 enrofloxacin 100 µM -0.832508107705559 0.212611345706533 no 2714 0.202561101852109 3970 71188 A bacterial gyrase inhibitor. SGTC_638 3970-0837 4.09 µM -0.835198127322236 0.211865880694542 no 2715 0.201803081959269 3869 4118451 YLR208W SEC13 SGTC_1232 0279-0259 161 µM -0.837352330707252 0.211270006556562 no 2716 0.20119727610963 3899 1560000 SGTC_172 1112-0046 2.638 µM -0.843254078924597 0.20964256227716 no 2717 0.199543179644362 3863 2802135 YIL048W NEO1 SGTC_2982 9019404 25.97 µM -0.843772867432478 0.209499856464942 no 2718 0.199398169996861 3857 22333232 SGTC_732 3970-1727 52.7 µM -0.846481133226221 0.208755808320152 no 2719 0.198642197242259 3946 1275699 SGTC_344 k064-0035 6.43 µM -0.847512615255002 0.208472836877057 no 2720 0.198354729253173 3865 5088750 SGTC_2469 5655019 90.81 µM -0.847776179299527 0.208400568379625 no 2721 0.198281315789651 3972 2788239 SGTC_1934 st074720 32.6 µM -0.847808748276902 0.208391639086251 no 2722 0.198272245123953 3847 17250992 SGTC_2276 7947513 42.08 µM -0.849332148301312 0.207974227382784 no 2723 0.197848248492365 3849 2105100 SGTC_978 1416-0512 87.4 µM -0.851618735021041 0.207348629812844 no 2724 0.197212868878548 3974 6814003 SGTC_958 1222-0007 33 µM -0.851774438994547 0.207306070560289 no 2725 0.197169647963308 3995 7312461 SGTC_2098 5376439 882.5 nM -0.852713181239592 0.207049589477478 no 2726 0.196909189696827 3923 2844116 SGTC_1633 st005664 67.9 µM -0.855747959146383 0.206221719685331 no 2727 0.196068603120717 3931 2063822 SGTC_2195 6536160 144.242 µM -0.859466535833711 0.205209993358085 no 2728 0.195041587436138 3840 3834386 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.859837959090977 0.20510910116947 no 2729 0.194939185794971 3731 6708630 An antioxidant. SGTC_3214 9129694 49.47 µM -0.860467658529693 0.20493811906214 no 2730 0.194765651948759 3914 17158655 SGTC_2244 6635614 200 µM -0.863995836290537 0.203981682599591 no 2731 0.193795088922849 3844 836499 SGTC_1447 4239-0816 81.9 µM -0.866145113097149 0.20340035146482 no 2732 0.193205294139959 3925 1341554 SGTC_520 3584-0023 682 µM -0.866201245487344 0.203385182169966 no 2733 0.19318990523966 3935 1340790 SGTC_2165 5727197 32.143 µM -0.867671051718819 0.202988219982047 no 2734 0.192787218814665 4100 1361712 SGTC_2144 5628481 200 µM -0.869113171746491 0.202599185276944 no 2735 0.192392616457569 3916 2818399 SGTC_1924 st058459 75.1 µM -0.870277859286133 0.202285317919308 no 2736 0.192074287778214 3874 688683 SGTC_11 0438-0307 1.3 µM -0.870908659212778 0.202115447455625 no 2737 0.191902014181764 3921 4011476 SGTC_1494 4358-1428 177 µM -0.871570767214983 0.20193723777262 no 2738 0.191721292020476 3938 1564571 SGTC_2990 9074105 71.4286 µM -0.872552637802587 0.201673135627169 no 2739 0.19145348271893 3873 6502001 SGTC_885 0865-0106 16.8 µM -0.873149216630213 0.201512769796818 no 2740 0.191290875356456 3854 2793380 SGTC_1966 st070145 16.1 µM -0.875315651186163 0.20093105529295 no 2741 0.190701090228947 3888 3748532 SGTC_1043 0916-0009 19.3 µM -0.876413738750954 0.200636590342497 no 2742 0.190402576077156 3952 3101130 SGTC_2401 5128683 200 µM -0.87752545049991 0.20033873599208 no 2743 0.190100650714714 3939 708373 SGTC_367 0335-0881 7.1 µM -0.877873152810945 0.20024563273343 no 2744 0.190006280064204 3938 23828853 SGTC_3327 9140648 26.9345 µM -0.878003269380273 0.200210798476242 no 2745 0.189970972244838 3965 8029710 SGTC_1654 st012436 41.8 µM -0.87871624424219 0.20001998851928 no 2746 0.189777574350806 3882 4323132 SGTC_2602 kawain 100 µM -0.879778838438088 0.199735814637896 no 2747 0.189489565305062 3906 5369129 SGTC_107 0358-0022 2.6945 µM -0.881519998943018 0.199270694415885 no 2748 0.189018217214955 3976 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1243 0416-0003 5.65 µM -0.882575203366746 0.198989132931406 no 2749 0.188732915501258 3950 2141977 SGTC_1652 st011932 78 µM -0.884956170980762 0.198354697825604 no 2750 0.18809013534364 3861 1551076 SGTC_296 1222-0039 74.9 µM -0.887631975246595 0.197643158883963 no 2751 0.187369373992792 3949 5984176 SGTC_3161 9100388 49.47 µM -0.888225178148983 0.197485625960888 no 2752 0.187209818881474 4015 25236368 SGTC_1907 st060210 83.7 µM -0.888966472593281 0.197288872109028 no 2753 0.187010549397663 4009 688793 SGTC_2270 7924575 90.91 µM -0.890706172322618 0.196827588132852 no 2754 0.186543411308486 3973 1262135 SGTC_2206 7254556 146.969 µM -0.890922276747768 0.196770333358467 no 2755 0.186485434202068 3967 4398905 SGTC_2124 5246320 200 µM -0.891096757553789 0.196724113718809 no 2756 0.186438632141642 3980 579342 SGTC_1104 tacrolimus 29.8 µM -0.891690329552162 0.19656692684532 no 2757 0.186279469153915 3981 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_859 0439-0102 54.6 µM -0.892635269338991 0.19631684949848 no 2758 0.186026262634843 3929 610143 SGTC_1184 1269-1718 139 µM -0.89431496778952 0.19587279542507 no 2759 0.185576696887074 4027 5403821 SGTC_1312 1218-2183 165 µM -0.894672456952924 0.195778366398136 no 2760 0.185481103177877 3964 6744073 SGTC_878 0828-0289 13.7 µM -0.895297286976924 0.195613386944493 no 2761 0.185314095104607 3916 745350 YLR208W SEC13 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.896533581955042 0.195287205769381 no 2762 0.184983926487019 4027 165506 SGTC_1348 1493-0373 93.8 µM -0.89775562120398 0.194965110781068 no 2763 0.184657924494163 3958 3010129 SGTC_68 0986-0284 82.829 µM -0.898101662989542 0.194873962668149 no 2764 0.184565676265803 4060 423278 YIL048W NEO1 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.898866232271631 0.194672665462601 no 2765 0.184361958118969 3891 756377 SGTC_725 1497-0963 19 µM -0.898908843096526 0.194661450529354 no 2766 0.184350608656416 4047 3549977 SGTC_2876 9059903 25.97 µM -0.899135936328175 0.194601687478246 no 2767 0.184290129336741 3906 6916095 SGTC_281 1672-3440 14.9 µM -0.900698826458648 0.194190691981187 no 2768 0.183874236411982 4020 6833000 SGTC_2489 cantharidin 73.42 µM -0.900782127009862 0.194168801163894 no 2769 0.183852086136581 3919 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3224 9130643 49.47 µM -0.901413448162164 0.194002943134393 no 2770 0.183684266880594 3993 17644395 SGTC_1211 1056-0033 32.3 µM -0.901423358330624 0.194000340265118 no 2771 0.183681633297676 4015 6741922 SGTC_54 0159-0055 9 µM -0.904080671726022 0.193303174683457 no 2772 0.182976313226337 3938 3319099 SGTC_3168 9103419 49.47 µM -0.904333203071553 0.193237000886056 no 2773 0.182909372887658 3960 16649256 SGTC_2801 7907800 81.82 µM -0.905603618253253 0.192904308644752 no 2774 0.182572846493534 4014 6620925 SGTC_2271 7849410 118.62 µM -0.906676626532914 0.19262358539901 no 2775 0.182288913589606 3871 972430 SGTC_1139 k015-0024 46.9 µM -0.908601449764831 0.192120634145433 no 2776 0.181780270514574 4001 2766652 SGTC_849 0386-0493 241 µM -0.910628964189186 0.191591719774149 no 2777 0.181245452020902 3951 726119 SGTC_618 k072-0232 33.2 µM -0.91064858984954 0.191586604422747 no 2778 0.18124027997732 4033 5872756 YGL099W LSG1 SGTC_591 4299-0174 154 µM -0.912393651101405 0.191132095544453 no 2779 0.180780765244421 3967 5509088 SGTC_2572 astragaloside iv 100 µM -0.912735488605681 0.191043139964337 no 2780 0.180690837194133 4062 45006101 An anti-inflammatory agent. SGTC_1347 1493-0251 600 nM -0.913547268572412 0.190831994112928 no 2781 0.180477392618492 4042 3986378 SGTC_1077 5-fluorocytosine 377 nM -0.913665503452647 0.190801252896786 no 2782 0.180446317846224 4015 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1713 st033146 12.748 µM -0.914039755358354 0.190703966968352 no 2783 0.180347978199749 3958 674619 SGTC_1739 st037196 92.5 µM -0.919917018778647 0.189180181398862 no 2784 0.178808062298394 4074 612214 SGTC_2134 5324836 1.464 µM -0.920352976967866 0.189067450924136 no 2785 0.178694166543319 3961 699272 SGTC_472 calcifediol 10 µM -0.921104610379114 0.188873190039509 no 2786 0.178497906716669 4031 5283731 A vitamin D metabolite. SGTC_2109 5483026 200 µM -0.924053916321817 0.188112125851291 no 2787 0.177729122511808 4009 759335 SGTC_995 3931-2021 34.6 µM -0.924117392047825 0.188095766864501 no 2788 0.177712599536028 4006 730143 SGTC_1810 st050138 53 µM -0.924299331872494 0.188048882133394 no 2789 0.177665245269718 3973 3444541 SGTC_356 1634-0012 32.5 µM -0.925779177655342 0.187667803333306 no 2790 0.177280375197431 3993 735457 SGTC_517 1365-0151 113 µM -0.926970386631227 0.187361398957857 no 2791 0.176970954956353 4069 768657 SGTC_1031 k035-0009 16 µM -0.927192747435773 0.187304237283465 no 2792 0.176913233863996 4070 5180959 SGTC_128 0906-2981 13.371 µM -0.928140485193679 0.187060725901842 no 2793 0.176667350664749 3945 6740226 SGTC_1089 terbinafine 2.25 µM -0.929578478394877 0.186691622661598 no 2794 0.176294687377491 4006 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1529 apigenin 74 µM -0.930283784594437 0.186510750005999 no 2795 0.176112085629032 4025 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_475 α-linolenic acid 10 µM -0.932624911296083 0.18591115676664 no 2796 0.175506833311834 4016 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3036 9090181 49.47 µM -0.933186523946212 0.185767498362434 no 2797 0.175361835695426 4025 25236586 SGTC_1134 3477-0009 42.5 µM -0.935800849197684 0.185099670520167 no 2798 0.174687867097805 4126 3973534 SGTC_654 1124-0271 80.9 µM -0.93625292773228 0.184984338751191 no 2799 0.174571489016617 4010 5403748 SGTC_702 1488-0190 94 µM -0.938461839811661 0.184421455651102 no 2800 0.174003559448522 4057 949357 SGTC_1751 st044839 27.194 µM -0.941147944502157 0.183738409894462 no 2801 0.173314524380494 3996 5291326 SGTC_3133 9127736 49.47 µM -0.941917227309999 0.183543080745726 no 2802 0.17311750968522 3977 27243420 SGTC_269 exalamide 29 µM -0.943137986354412 0.18323338268999 no 2803 0.172805164035314 3942 3316 A derivative of salicylamide. SGTC_2463 5473429 200 µM -0.943201174789864 0.183217361100671 no 2804 0.172789006309095 4013 5399405 SGTC_181 1447-1644 8.07 µM -0.944359571320534 0.182923801540304 no 2805 0.172492966838778 4043 534600 SGTC_1872 amphotericin b 148 nM -0.945980469856345 0.182513528267566 no 2806 0.172079273820344 4037 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_157 1348-1695 65.819 µM -0.946551018591018 0.182369250854138 no 2807 0.17193380662114 3988 5380510 SGTC_1162 k048-0130 20.1 µM -0.948604850338429 0.181850478683057 no 2808 0.171410811596741 3991 6797406 SGTC_2491 paeonol 100 µM -0.948767497857457 0.181809435437398 no 2809 0.171369437949521 3895 11092 Increases levels of cortical cytochrome oxidase. SGTC_2357 9067248 200 µM -0.953463817363075 0.180626843989455 no 2810 0.170177560204951 4037 9150235 SGTC_3172 9105863 49.47 µM -0.953973948323718 0.180498677772427 no 2811 0.170048414780544 4057 2348785 SGTC_1641 st009299 47.1 µM -0.954489155845251 0.180369294025276 no 2812 0.169918047941904 3937 4046054 SGTC_2787 5284540 71.43 µM -0.954564034785203 0.180350494567642 no 2813 0.169899106094333 4094 736958 SGTC_896 0964-0007 44.5 µM -0.955460337704277 0.180125560001066 no 2814 0.169672476767567 3975 6756758 SGTC_886 0866-0150 153 µM -0.95557769106772 0.18009612225636 no 2815 0.169642818445678 4098 271463 SGTC_764 1951-2361 146 µM -0.955615118973955 0.180086734211877 no 2816 0.169633360115965 4017 5438930 SGTC_1606 st000094 49.2 µM -0.958821413917949 0.179283639741536 no 2817 0.168824359763644 4074 1242210 SGTC_1467 k284-1082 293 µM -0.958994232474237 0.17924041719865 no 2818 0.168780825356402 4010 3334705 SGTC_2148 5546263 113.568 µM -0.959295419959746 0.179165104789403 no 2819 0.168704971009454 4028 792097 SGTC_2630 antimycin a 100 µM -0.959335203169693 0.179155158423001 no 2820 0.168694953209601 4000 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1316 1272-0050 65.9 µM -0.961346125593718 0.178652851866879 no 2821 0.168189081463442 4001 7340392 SGTC_907 3448-6986 75.5 µM -0.963200527630618 0.178190429179127 no 2822 0.167723450195855 4083 590582 SGTC_889 0919-1524 82.7 µM -0.963772164588459 0.178048035272668 no 2823 0.167580082504698 4068 3905452 SGTC_1982 st072467 71.9 µM -0.967753654220637 0.177058243144458 no 2824 0.166583707466141 4020 3163533 SGTC_2107 5363541 170.161 µM -0.974072357002488 0.175494575170069 no 2825 0.165010306856711 4034 244052 SGTC_480 am 92016 50 µM -0.975590603472919 0.175120168035819 no 2826 0.164633691435235 4031 2129 K+ channel blocker. SGTC_1464 k208-0027 110 µM -0.975778628086945 0.175073835515935 no 2827 0.164587088938769 4059 X1464 SGTC_2596 sinensetin 100 µM -0.976961018046532 0.174782652399268 no 2828 0.164294225767707 4083 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3296 9122258 64.045 µM -0.9781922994571 0.174479755895876 no 2829 0.16398961216246 4062 4730474 SGTC_897 1000-0139 31.4 µM -0.978676261044056 0.17436079217652 no 2830 0.163869982576668 4006 6151020 SGTC_3218 9131285 49.47 µM -0.979735281837357 0.17410065162739 no 2831 0.163608402757249 4022 17156417 SGTC_1414 3917-0015 5.4 µM -0.982078866786012 0.173525845095877 no 2832 0.163030497939894 4026 6618702 SGTC_1483 3453-0561 55.9 µM -0.982224624420024 0.173490135341931 no 2833 0.162994599435211 4074 4546991 SGTC_948 3448-0295 75.3 µM -0.982457493826781 0.173433093427484 no 2834 0.162937256921459 4047 678569 SGTC_999 SEC7.066 22.7 µM -0.983483822187608 0.173181834129764 no 2835 0.16268468682438 4046 740511 YDR170C SEC7 SGTC_2558 carylophyllene oxide 100 µM -0.983915637467184 0.173076189132098 no 2836 0.162578497159077 4180 6708694 An oxygenated terpenoid and antifungal agent. SGTC_893 0958-0369 48.9 µM -0.985699302743683 0.172640244797993 no 2837 0.162140345871368 4012 6819948 SGTC_1314 1222-0010 41.1 µM -0.985843601779621 0.172605007410906 no 2838 0.162104932956743 4079 3526027 SGTC_2516 gossypol 71.55 µM -0.986735471289773 0.172387317354918 no 2839 0.161886168026868 4119 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_967 1306-0166 352 µM -0.98792175583492 0.172098037160928 no 2840 0.161595484819256 4064 4437607 SGTC_597 k018-0003 82.8 µM -0.988218999158386 0.172025601769008 no 2841 0.161522702649405 4133 6786234 SGTC_945 3381-0768 11.3 µM -0.989072666208654 0.171817679396886 no 2842 0.161313794971521 4118 1126236 YIL048W NEO1 SGTC_2763 lisinopril 49.32 µM -0.98922470329635 0.171780665513733 no 2843 0.161276607259095 3952 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1883 5-benzylidenerhodanine 20 µM -0.989299094108915 0.171762556703868 no 2844 0.161258413577625 4067 1273210 SGTC_3232 9132874 49.47 µM -0.991203897961364 0.171299289388173 no 2845 0.160793013801966 4035 3784940 SGTC_2854 9024559 71.43 µM -0.991485603819127 0.171230843578569 no 2846 0.160724259264892 4130 3163529 SGTC_2594 a-mangostin 100 µM -0.996490102517843 0.170017820761922 no 2847 0.159506036829833 4119 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2987 9018338 71.43 µM -0.999075411730089 0.169393339824183 no 2848 0.158879080650961 4122 5055682 SGTC_2493 resveratrol 26.09 µM -1.00297313476336 0.16845463209093 no 2849 0.157936911810878 3986 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2341 7987486 176.74 µM -1.005505740218 0.167846488607483 no 2850 0.157326693413885 4137 1258686 SGTC_1560 lithocholic acid 53.1 µM -1.00959357422445 0.166867880759253 no 2851 0.156345024744588 3982 9903 A bile acid which acts as a detergent. SGTC_809 3998-0021 90 µM -1.01254477715329 0.166163669380814 no 2852 0.155638824256553 4049 715485 SGTC_1525 8-methoxypsoralen 92.5 µM -1.0131291449937 0.166024456485858 no 2853 0.155499239392528 4174 4114 Related to psoralen; DNA damaging agent. SGTC_841 0251-0215 91.2 µM -1.01839368752689 0.164773693142809 no 2854 0.154245450438742 4132 3888614 SGTC_1556 plumbagin 1.48 µM -1.02182857710929 0.163960922541916 no 2855 0.153431020680747 4035 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2313 7726885 200 µM -1.02252252580616 0.163797035369035 no 2856 0.153266828418386 4152 726423 SGTC_2465 5809242 33.21 µM -1.02282497823438 0.163725639631822 no 2857 0.153195302872681 4149 2731748 SGTC_2889 9059656 51.95 µM -1.02338980188722 0.163592363666282 no 2858 0.153061789630515 4194 3949838 SGTC_1603 st002045 67.8 µM -1.02390481623008 0.1634709021378 no 2859 0.152940117580438 4116 5887985 SGTC_1155 4088-0394 48.2 µM -1.02511176566982 0.163186483430026 no 2860 0.152655227283906 4074 2326248 SGTC_2031 5180455 200 µM -1.02900110464262 0.162272146417402 no 2861 0.151739577890452 4068 29949 SGTC_2658 polymyxin b sulfate 77.05 µM -1.02913255402044 0.162241302620322 no 2862 0.151708695256583 4147 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3141 9094609 49.47 µM -1.02996576391513 0.162045883767644 no 2863 0.151513038610367 4081 25236309 YDL196W YDL196W SGTC_1204 4049-0315 18.3 µM -1.03056078644304 0.1619064226238 no 2864 0.15137341650489 4188 588402 SGTC_2621 lithochol-11-enic acid 100 µM -1.03157182032436 0.16166963626911 no 2865 0.151136373556956 4049 6708711 SGTC_690 glyoxal 20.3 µM -1.03167721672356 0.161644965198969 no 2866 0.151111676962309 3925 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1656 st012921 11 µM -1.03350874462489 0.161216635095844 no 2867 0.150682940183919 4041 6732821 SGTC_836 0330-0104 1.35 µM -1.03560709743676 0.160726814965844 no 2868 0.150192739741149 4142 46494820 SGTC_42 0133-0086 60.653 µM -1.03562947677321 0.160721596182962 no 2869 0.150187517394232 4005 162923 Model of phenazepam hydroxylation. SGTC_3263 9137018 49.47 µM -1.03687354943692 0.160431656852597 no 2870 0.149897396255569 4117 43844957 SGTC_1222 0366-0074 1.18 µM -1.03895232150843 0.159947948427986 no 2871 0.149413455497749 4148 286520 SGTC_1644 st010134 20.9 µM -1.03994719038842 0.159716790715518 no 2872 0.149182218182452 4106 3818134 SGTC_2551 apiole 73.87 µM -1.04158745299542 0.159336153341349 no 2873 0.148801494145056 4020 10659 A possible DNA adduct former. SGTC_2961 9083290 32.55 µM -1.04223571330293 0.159185882734866 no 2874 0.148651204572088 4063 17741490 SGTC_2810 7959871 45.46 µM -1.05248233186627 0.156822988960688 no 2875 0.146289156228575 4111 2974535 SGTC_2871 9038510 12.99 µM -1.05532701399292 0.156171112961986 no 2876 0.145637895163068 4086 4945164 SGTC_1428 4049-0204 61.7 µM -1.05645231529201 0.155913736927406 no 2877 0.145380807769186 4211 X1428 SGTC_321 4534-3890 65.3 µM -1.05746633748959 0.155682052002117 no 2878 0.145149404940709 4148 699746 SGTC_2335 9018011 154.17 µM -1.05795313784739 0.155570908017688 no 2879 0.145038403784282 4155 6458208 SGTC_1938 st074717 56.4 µM -1.05939525959843 0.155241956790433 no 2880 0.144709903831533 4044 17250979 SGTC_2722 naftopidil 47.16 µM -1.06293331031862 0.15443686568856 no 2881 0.143906097850313 4071 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2308 7584454 197.62 µM -1.06400752709034 0.154192972568282 no 2882 0.143662644852133 4222 893577 SGTC_1377 2944-0135 198 µM -1.06638658802835 0.153653731387541 no 2883 0.143124460998169 4198 1894137 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.06659394630233 0.153606790508376 no 2884 0.143077617659638 4140 2724 A muscle relaxant with antifungal properties. SGTC_2610 ononetin 44.17 µM -1.06808923941099 0.153268573601333 no 2885 0.142740129655037 4151 259632 SGTC_3266 9136860 49.47 µM -1.06872277907956 0.153125423654179 no 2886 0.142597302044149 4004 4871271 YPR165W RHO1 SGTC_898 1000-0849 28.3 µM -1.06914659636045 0.153029710513012 no 2887 0.142501809019395 4149 6751807 SGTC_2444 5485484 36.41 µM -1.07217679659185 0.152346538283232 no 2888 0.141820315141434 4246 6790631 SGTC_934 2950-0684 338 µM -1.07568504777638 0.151558119815545 no 2889 0.141034068381663 4214 1121253 SGTC_1640 st009078 66.4 µM -1.07799516553583 0.15104044472275 no 2890 0.14051795680551 4145 690618 SGTC_3138 9097216 49.47 µM -1.07881122578198 0.1508578550747 no 2891 0.140335944749185 4132 25237486 SGTC_3343 9148379 18.9835 µM -1.08246552201636 0.150042026246034 no 2892 0.139522863763898 4208 1955036 SGTC_130 0136-0219 337.655 µM -1.08264969695341 0.15000098683789 no 2893 0.139481969818046 4013 234244 SGTC_2370 9071495 200 µM -1.08322634546747 0.149872541574222 no 2894 0.139353984313712 4188 21791103 SGTC_2891 9063876 19.48 µM -1.08343865264416 0.149825269806971 no 2895 0.13930688346652 4168 6472478 SGTC_1590 st077108 57.8 µM -1.0843048906881 0.149632498560228 no 2896 0.139114818782375 4198 5489485 SGTC_2655 perillic acid 100 µM -1.08501854799743 0.149473806779783 no 2897 0.138956720190753 4196 5702197 An apoptosis inducer. SGTC_2823 7987624 58.44 µM -1.08626903248157 0.149196014847369 no 2898 0.138679991768187 4187 2239440 SGTC_763 3453-1109 128 µM -1.08953773858089 0.148471509510095 no 2899 0.137958411114793 4197 1560353 SGTC_2190 6049624 200 µM -1.09149390811821 0.148039053726315 no 2900 0.137527805493744 4062 2265554 SGTC_2942 9052777 62.25 µM -1.09262268530242 0.147789895811809 no 2901 0.13727974912759 4255 6469503 SGTC_2611 pyromycin 23.93 µM -1.0971472662557 0.146793993171732 no 2902 0.136288510474226 4154 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_761 k216-0224 480 µM -1.10037293772784 0.146086747914041 no 2903 0.135584832314769 4232 1340404 SGTC_2676 harmalol 100 µM -1.10234728656348 0.145654992801391 no 2904 0.135155359530827 4148 5459187 A monoamine oxidase inhibitor SGTC_1167 k781-0610 148 µM -1.10251256447695 0.145618888404911 no 2905 0.135119449596559 4230 4525169 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.10294897908944 0.145523584044582 no 2906 0.135024661235455 4191 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1079 idarubicin 2.36 µM -1.1062411618733 0.144805988030764 no 2907 0.134311075554423 4206 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2277 7947813 106.88 µM -1.10715986152868 0.144606165344784 no 2908 0.134112409019439 4253 1246798 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.10720234906406 0.144596928547165 no 2909 0.134103226081278 4182 442882 SGTC_603 3794-0023 45.9 µM -1.10723760206051 0.144589264841293 no 2910 0.134095607090165 4240 3802260 SGTC_1748 st037455 53.6035 µM -1.10855822891543 0.144302368758384 no 2911 0.133810403185135 4253 580690 SGTC_1109 tnp00067 928.257 nM -1.10928497215146 0.144144653136418 no 2912 0.13365363296833 4199 676295 SGTC_3342 9147791 14.508 µM -1.11009473029182 0.143969058814957 no 2913 0.133479103901284 4126 1838168 SGTC_363 0455-0021 3.06 µM -1.1123994337466 0.143470078729191 no 2914 0.132983223994367 4160 4597466 SGTC_1279 0874-0590 65.2 µM -1.11251205392086 0.143445725841666 no 2915 0.132959025184738 4261 3523074 SGTC_1561 5-methoxyflavone 52.9 µM -1.113404671464 0.143252805730215 no 2916 0.132767334794015 4145 94525 SGTC_134 0269-0018 6.916 µM -1.1156296367865 0.142772690327995 no 2917 0.132290350348005 4174 4378915 SGTC_1811 st050069 61.5 µM -1.11617677226937 0.14265479321247 no 2918 0.132173237504527 4180 3877702 SGTC_2471 5466956 24.79 µM -1.1162083759055 0.142647985251588 no 2919 0.13216647501756 4192 724419 SGTC_102 gallobenzophenone 83.616 µM -1.11898668703303 0.142050348222697 no 2920 0.131572909298243 4210 70837 SGTC_3332 9141069 11.198 µM -1.12094339065893 0.141630464154597 no 2921 0.131155979784342 4159 17332883 SGTC_2278 7948257 134.34 µM -1.1264826611779 0.1404463689742 no 2922 0.129980637821814 4222 1247028 SGTC_828 2074-0507 139 µM -1.12650724897375 0.140441128022913 no 2923 0.129975437002148 4283 X828 SGTC_270 tamoxifen 5.46 µM -1.12865545397861 0.139983745207906 no 2924 0.129521603880121 4277 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2588 indole-3-carbinol 100 µM -1.12907265374183 0.139895035071638 no 2925 0.12943359307448 4257 3712 Induces cell cycle arrest. SGTC_1470 k295-0292 231 µM -1.13174484816897 0.1393277464674 no 2926 0.128870860297625 4302 5045612 SGTC_743 1275-0778 158 µM -1.13356016684545 0.138943260703601 no 2927 0.128489544855423 4205 2849257 YMR203W TOM40 SGTC_2371 9071574 200 µM -1.13931033609903 0.137730142335073 no 2928 0.127286869404178 4232 45596039 SGTC_3163 9099914 49.47 µM -1.14324029622717 0.136905205126608 no 2929 0.126469417925977 4262 16268368 SGTC_571 k831-0106 44.2 µM -1.14325764565092 0.13690157081499 no 2930 0.126465817285808 4102 4783639 SGTC_71 0417-1750 47.813 µM -1.143861619743 0.136775093013433 no 2931 0.126340515081022 4238 6811472 SGTC_1423 4048-0112 5.59 µM -1.14686631810264 0.136147068531163 no 2932 0.125718437548144 4278 X1423 SGTC_1826 st055655 41.6 µM -1.14903265722331 0.135695499263148 no 2933 0.125271257414698 4260 676168 SGTC_286 k060-0067 22.9 µM -1.15208621410605 0.135060735092048 no 2934 0.124642823756757 4261 5985051 SGTC_3203 9113543 49.47 µM -1.15402647378046 0.134658459440586 no 2935 0.124244657699235 4304 17018012 SGTC_1698 5-fluorocytosine 1.055 µM -1.15537501218495 0.134379350696911 no 2936 0.123968445002101 4248 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1685 st024049 53.0905 µM -1.15640774185126 0.134165874065659 no 2937 0.12375720820165 4264 1941139 SGTC_2188 6126565 140.678 µM -1.15697197958712 0.134049338351846 no 2938 0.123641904280551 4159 874518 SGTC_1976 st070609 63.5 µM -1.15699834370043 0.134043894900138 no 2939 0.123636518523554 4189 682556 SGTC_2845 9003024 42.97 µM -1.1605261670775 0.133316867655151 no 2940 0.122917323175475 4307 2990173 SGTC_1074 carmofur 3.8 µM -1.16087158239862 0.133245829250358 no 2941 0.122847063498311 4289 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1111 tnp00062 510.699 nM -1.16188715191778 0.133037117255914 no 2942 0.12264065332921 4290 676306 SGTC_1632 st005650 90 µM -1.16533839634452 0.132329526532956 no 2943 0.121941021354194 4285 2759605 SGTC_594 1487-1584 10.8 µM -1.16818285507048 0.131748295217506 no 2944 0.121366507344017 4210 5013332 SGTC_2436 5633522 8.09 µM -1.16861547516661 0.131660049010256 no 2945 0.121279295239735 4251 5724242 SGTC_2243 6634756 200 µM -1.16971266999528 0.131436425234246 no 2946 0.121058308827454 4317 885676 SGTC_513 4245-1575 41.7 µM -1.17029422941303 0.131318001614321 no 2947 0.12094129166839 4134 719745 SGTC_3237 9133362 49.47 µM -1.17080828839253 0.13121338455189 no 2948 0.120837922746904 4241 43845137 SGTC_2225 6654152 15.4 µM -1.17143122281828 0.131086687212842 no 2949 0.120712744087831 4157 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1832 st054113 55 µM -1.17214583374996 0.130941448094488 no 2950 0.120569255494894 4274 1251267 SGTC_2747 doxorubicin 7.63 µM -1.17449452829066 0.130464877671883 no 2951 0.12009850116377 4241 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1964 st076914 61 µM -1.1750958941107 0.130343048487576 no 2952 0.119978176573097 4307 24208661 SGTC_463 ikarugamyin 104 µM -1.17567138536659 0.130226534879421 no 2953 0.11986310869991 4406 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3046 9092212 49.47 µM -1.18229964530245 0.128889775217792 no 2954 0.118543413138526 4339 25236637 SGTC_2138 5575593 77.673 µM -1.18244778402814 0.128860008351916 no 2955 0.118514036291821 4276 762213 SGTC_2690 usnic acid 100 µM -1.18510711502125 0.128326455757134 no 2956 0.117987549142333 4303 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_186 3455-3465 67.277 µM -1.18566137549003 0.128215445623159 no 2957 0.11787802682891 4274 755278 SGTC_1643 st009866 20.2 µM -1.18603637431916 0.128140376765384 no 2958 0.117803967568005 4226 3156273 YOR207C RET1 SGTC_964 1287-0107 19.4 µM -1.18905419170022 0.127537368568032 no 2959 0.117209171353379 4291 51516812 YPR165W RHO1 SGTC_387 norethindrone acetate 66.7 µM -1.19044725670749 0.12725967855031 no 2960 0.116935324301063 4288 541197 SGTC_1647 st011722 22.4 µM -1.19366881647125 0.126619112948496 no 2961 0.116303771602902 4255 2854783 SGTC_2563 tomatine 8.54 µM -1.19581099953914 0.12619441259247 no 2962 0.115885161251701 4258 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1852 st056254 31.4 µM -1.19670737831714 0.126016995236034 no 2963 0.115710315087673 4231 442583 SGTC_2103 5378138 10 µM -1.19889552135842 0.125584633817848 no 2964 0.115284286720497 4358 244142 SGTC_2340 7987427 183.45 µM -1.1989016203699 0.125583430145172 no 2965 0.11528310081184 4300 2239331 SGTC_2217 6934799 96.0675 µM -1.19942183156194 0.125480793297074 no 2966 0.115181981419924 4257 675606 SGTC_1251 0490-5699 265 µM -1.19991519245855 0.125383508072227 no 2967 0.115086139501614 4326 3883818 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.20053473641992 0.125261415552054 no 2968 0.11496586517938 4319 688788 SGTC_1813 st051246 8.6015 µM -1.20153503356418 0.125064463870026 no 2969 0.114771862597649 4225 5291959 SGTC_1288 0973-0013 65.5 µM -1.20265023708276 0.124845143008821 no 2970 0.114555849221363 4310 4315430 SGTC_395 anisomycin 6.25 µM -1.20635487398355 0.124118502447237 no 2971 0.113840343888793 4299 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1954 st077032 68.9 µM -1.20798087468845 0.123800509118009 no 2972 0.113527309484497 4244 698907 SGTC_2374 9071832 200 µM -1.2105833627872 0.123292734065408 no 2973 0.113027561868289 4220 17381698 SGTC_2490 carminic acid 95.39 µM -1.21059931750799 0.123289625624967 no 2974 0.113024502983107 4260 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1995 st072814 61.1 µM -1.21279037055785 0.122863266681391 no 2975 0.112604988976212 4252 5769371 SGTC_2018 5133068 143 µM -1.21306446016476 0.122810004190051 no 2976 0.112552588268549 4256 785362 SGTC_1235 benzylparaben 21.5 µM -1.21435326651807 0.122559773850683 no 2977 0.112306426563262 4323 7180 SGTC_216 k038-0035 28.382 µM -1.21642976890226 0.122157359959582 no 2978 0.111910624798013 4212 4444231 YPR107C YTH1 SGTC_2645 abamectin 100 µM -1.21661921146863 0.122120693342108 no 2979 0.111874564897867 4249 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2553 4-methylesculetin 85.09 µM -1.2167656217256 0.12209236092477 no 2980 0.111846701779019 4323 5319502 SGTC_2916 7875993 68.79 µM -1.21821758257642 0.121811636189763 no 2981 0.111570649892886 4131 1299250 SGTC_1360 1598-0022 39.8 µM -1.21905326555055 0.121650269496771 no 2982 0.111411988130441 4343 761525 SGTC_2549 cedrol 20.94 µM -1.21962094589098 0.121540738650836 no 2983 0.111304301174291 4245 6708665 A sedative which affects the nervous system. SGTC_479 n-linoleoylglycine 10 µM -1.21990640742801 0.121485686594634 no 2984 0.111250178292309 4346 6433346 An anti-infammatory. SGTC_3249 9135183 49.47 µM -1.22047053888248 0.121376943820501 no 2985 0.111143275619789 4287 4902779 SGTC_1853 st056710 91.2 µM -1.22103749451466 0.121267725625002 no 2986 0.111035911897978 4363 269167 SGTC_3229 9132204 49.47 µM -1.22224158663374 0.121035998914854 no 2987 0.110808140827701 4366 17682924 SGTC_1205 4161-2785 76 µM -1.22340663799581 0.120812082280273 no 2988 0.11058807371829 4340 3498106 SGTC_1310 1188-0297 994 nM -1.22379477067454 0.120737550042575 no 2989 0.110514828763805 4181 1588352 SGTC_3309 9129340 25.759 µM -1.22502207100809 0.120502087349525 no 2990 0.110283452393576 4322 17158987 SGTC_449 xestospongin c 11.1929 µM -1.227093876049 0.120105336965304 no 2991 0.109893654654713 4312 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_253 dyclonine 31.25 µM -1.23017752512372 0.11951652480837 no 2992 0.109315317063791 4416 3180 An oral anasthetic. SGTC_1116 jasmonic acid  1.58368 µM -1.23171959635253 0.119222836668578 no 2993 0.109026923501274 4362 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_637 1181-0519 7.26 µM -1.23288927403811 0.119000411022889 no 2994 0.108808538865301 4309 6252091 YGR060W ERG25 SGTC_3015 9080845 49.47 µM -1.2332596466898 0.118930042161066 no 2995 0.108739454059266 4348 5296973 SGTC_1631 benzylvanillin 81.9 µM -1.23495090354114 0.118609085708658 no 2996 0.108424388467612 4370 75506 SGTC_310 1273-0058 1.06 µM -1.23635271254618 0.118343523175879 no 2997 0.108163742603751 4109 2734232 SGTC_568 1193-0097 7.48 µM -1.23846971577679 0.117943269484501 no 2998 0.107770972247168 4120 3646150 SGTC_2704 st078022 71.1 µM -1.23887647694138 0.117866474521112 no 2999 0.107695623134817 4345 54697681 SGTC_2273 7815444 169.05 µM -1.24144166142807 0.117382992471182 no 3000 0.107221318390546 4275 2824616 SGTC_1791 st048313 56.1 µM -1.24346659995767 0.117002328309622 no 3001 0.106847970730663 4331 1204976 SGTC_419 nsc-638432 893 µM -1.24430683024038 0.116844632172473 no 3002 0.106693329096364 4285 368090 SGTC_1138 3761-0006 1.03 µM -1.24500931087143 0.116712904853766 no 3003 0.106564163864598 4350 12061087 SGTC_979 1426-2828 121 µM -1.24574191554276 0.116575640952133 no 3004 0.106429580004915 4411 747872 SGTC_1796 st049173 110.4 µM -1.24964144510263 0.115846935143593 no 3005 0.105715278067749 4288 94134 SGTC_2185 6113692 200 µM -1.24977645881596 0.115821763170836 no 3006 0.105690608964292 4323 874150 SGTC_1970 st070122 35.8 µM -1.25104569212901 0.115585317033638 no 3007 0.105458903762339 4345 102928 SGTC_1839 st053978 48 µM -1.25302766537368 0.11521678040085 no 3008 0.105097819316536 4353 3788398 SGTC_1847 st056231 15 µM -1.25588487612333 0.114686969684013 no 3009 0.104578856331994 4323 5393180 SGTC_1353 1498-1206 8.11 µM -1.25619972594334 0.114628693502496 no 3010 0.104521783049411 4363 6756808 SGTC_1799 st045822 46.1415 µM -1.25632096596119 0.114606258566355 no 3011 0.104499811714653 4321 3674992 SGTC_2753 fluvastatin 17.09 µM -1.25666099131217 0.114543355031397 no 3012 0.104438209559485 4331 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2740 felodipine 17.08 µM -1.25666385529809 0.114542825308112 no 3013 0.104437690804928 4377 3333 L-type calcium channel blocker SGTC_1087 pterostilbene 9.05 µM -1.2685231567238 0.112364258267932 no 3014 0.10230559326027 4343 5281727 Similar to reservatol, lowers cholesterol. SGTC_501 nsc-95397 161 µM -1.2723078011337 0.111675286962944 no 3015 0.101631888951968 4359 262093 SGTC_3050 9093513 49.47 µM -1.2742159574778 0.111329067057817 no 3016 0.101293445696046 4311 25236664 SGTC_2347 9049783 174.81 µM -1.27556934490111 0.111083971777348 no 3017 0.101053898176271 4357 6467988 YPL169C MEX67 SGTC_992 3909-8734 162 µM -1.2758162991665 0.111039290660719 no 3018 0.101010232229886 4355 4288319 SGTC_109 0132-0036 33.701 µM -1.27595670882037 0.111013892263525 no 3019 0.100985411416994 4204 67274 A color developer. SGTC_110 0850-0284 111.64 µM -1.27687146703231 0.110848525491778 no 3020 0.100823814542011 4184 3906265 SGTC_1207 2099-0101 141 µM -1.27977657100157 0.110324521420753 no 3021 0.100311862988052 4357 5837381 SGTC_1623 st003709 20.3 µM -1.2809771587129 0.110108486636418 no 3022 0.100100844548163 4325 16192618 SGTC_2641 levomentholum 100 µM -1.28334161454774 0.109683912139343 no 3023 0.0996862096150227 4354 16666 SGTC_2126 5251174 33.877 µM -1.28859294148189 0.108745162287519 no 3024 0.0987698193102179 4351 790722 SGTC_1260 0700-1617 7.75 µM -1.28919605496149 0.108637718129167 no 3025 0.0986649680964225 4336 2853078 SGTC_59 0330-0160 1.33 µM -1.28930127213396 0.108618981603357 no 3026 0.0986466844516452 4310 4293482 SGTC_1939 st074455 53.6 µM -1.29497495425171 0.107612081290886 no 3027 0.0976644348011746 4347 1644229 SGTC_3146 9095609 49.47 µM -1.29655135898723 0.107333516690499 no 3028 0.097392798917262 4407 17173999 SGTC_1825 st052143 62.6 µM -1.29741122499238 0.107181790081365 no 3029 0.0972448661609811 4406 674173 SGTC_1356 1502-0781 85.8 µM -1.30006173956356 0.106715070030975 no 3030 0.0967899047881165 4359 567702 SGTC_3320 9137005 35.139 µM -1.30041189274551 0.106653522601979 no 3031 0.0967299180022312 4411 4908713 SGTC_1321 1326-2144 215 µM -1.30053148354496 0.106632507654816 no 3032 0.0967094364606005 4351 3513030 SGTC_112 phenothiazine 287.218 µM -1.30155301433633 0.106453122196035 no 3033 0.0965346152868396 4323 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2038 4100038 30.985 µM -1.30371973160007 0.10607335819495 no 3034 0.0961645796330981 4340 3596803 SGTC_2965 9082772 38.63 µM -1.30496325101797 0.105855847142178 no 3035 0.0959526807853287 4370 16459634 SGTC_1718 roemerine 11.9335 µM -1.30673707709592 0.105546135316854 no 3036 0.0956510108916203 4020 235224 An aporphine alkaloid with mutagenic activity. SGTC_2771 fluoxetine 41.05 µM -1.30732300044008 0.105443976628155 no 3037 0.0955515179518264 4376 3386 A selective serotonin reuptake inhibitor. SGTC_2750 bromebric acid 70.15 µM -1.30880650738059 0.105185639541953 no 3038 0.0952999510538809 4376 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2255 7941087 197.44 µM -1.31082856174616 0.104834258123156 no 3039 0.0949578453079035 4470 935561 SGTC_1228 0124-0032 52.5 µM -1.31176330409266 0.104672111346025 no 3040 0.0948000049850419 4418 X1228 SGTC_422 cantharidin 155 µM -1.31214437728276 0.104606059940853 no 3041 0.0947357125812172 4287 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.31278635773395 0.104494853772227 no 3042 0.0946274741313912 4262 4000243 SGTC_41 0478-0632 82.643 µM -1.31442004766363 0.104212246490173 no 3043 0.0943524438085937 4356 3750424 SGTC_1247 0448-0043 5.84 µM -1.31886601547928 0.103445957808383 no 3044 0.0936069547256108 4377 3089013 YGL099W LSG1 SGTC_3160 9100216 49.47 µM -1.31992023814561 0.103264857722093 no 3045 0.0934308249024474 4357 17191039 SGTC_104 0074-0074 590.992 µM -1.32063023037686 0.103143021197721 no 3046 0.0933123439553846 4235 3943124 SGTC_362 0310-0100 9.03 µM -1.32226972408903 0.102862078720667 no 3047 0.0930391753271669 4426 790235 SGTC_1373 2887-0003 58.5 µM -1.32404846429988 0.102557904367387 no 3048 0.0927434747976754 4337 776948 SGTC_778 3456-2434 196 µM -1.33100939014092 0.101373834469147 no 3049 0.0915929606030283 4329 5539063 SGTC_2287 7945887 168.79 µM -1.33429230409969 0.100818871848114 no 3050 0.0910540393919416 4406 1245853 SGTC_1618 st003135 44.5 µM -1.3352963930463 0.100649578109302 no 3051 0.0908896793479439 4364 1270615 SGTC_1168 k815-0004 80.5 µM -1.33554958367316 0.100606921828576 no 3052 0.090848269163119 4379 642433 SGTC_1973 st070275 50.2 µM -1.3358895285703 0.100549670366995 no 3053 0.0907926920411336 4334 17118334 SGTC_1985 st071382 65.5 µM -1.33685518321054 0.100387170316526 no 3054 0.0906349561253515 4381 6123237 SGTC_2075 5212009 200 µM -1.33716332265883 0.100335357065403 no 3055 0.0905846655830617 4323 780898 SGTC_2496 diffractaic acid 79.83 µM -1.33825405496014 0.100152108650431 no 3056 0.0904068167701733 4383 94870 An apoptosis inducer which activates caspases. SGTC_2679 rapamycin 1 nM -1.33855718668425 0.100101224437109 no 3057 0.0903574358503602 4267 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1432 4049-0298 68.4 µM -1.3421146898323 0.0995054658900901 no 3058 0.0897794057824146 4410 741646 SGTC_1289 0976-0073 69.1 µM -1.34635354640131 0.0987989927550841 no 3059 0.0890942623384954 4458 3391136 SGTC_662 k832-1615 104 µM -1.34682487946295 0.0987206649021358 no 3060 0.0890183199352085 4418 5878478 SGTC_2044 5102272 200 µM -1.34732061074428 0.0986383315116693 no 3061 0.0889384984271059 4383 592666 SGTC_935 2996-0153 430 µM -1.3495548885469 0.0982678758350498 no 3062 0.0885794013439042 4407 23738523 SGTC_163 TUB2.036 7.546 µM -1.34989486673804 0.0982115950104536 no 3063 0.0885248542563796 4350 15992207 YJR013W GPI14 SGTC_1389 3405-0187 19 µM -1.34990615933034 0.0982097260122441 no 3064 0.0885230428695942 4380 799890 SGTC_358 0075-0058 9.45 µM -1.35111543386627 0.0980097338843037 no 3065 0.0883292291067134 4366 1069125 SGTC_1175 0741-0056 27.6 µM -1.35157911411179 0.0979331287673134 no 3066 0.0882549977294188 4473 765927 SGTC_2796 7949634 45.45 µM -1.35169579898782 0.0979138580448167 no 3067 0.0882363247693055 4366 2971588 SGTC_2973 9094665 17.96 µM -1.35291918195673 0.0977119813869866 no 3068 0.0880407253146229 4395 25237061 YIL048W NEO1 SGTC_3335 9143315 29.6265 µM -1.3532113817983 0.0976638091812922 no 3069 0.0879940550794795 4412 4899691 SGTC_1323 1348-1351 11.2 µM -1.35406999046362 0.0975223593098647 no 3070 0.0878570246263271 4391 6989654 SGTC_960 1222-0186 7.7 µM -1.35533377745326 0.0973144325178461 no 3071 0.0876556189901607 4402 3126296 SGTC_1882 5615643 20 µM -1.35611712533792 0.097185714208914 no 3072 0.0875309524326841 4352 2253075 SGTC_2974 9094440 9.66 µM -1.3567276876177 0.0970854743930208 no 3073 0.0874338757790399 4397 25236134 SGTC_2219 9098279 200 µM -1.35810134935534 0.0968602292388269 no 3074 0.0872157635592579 4348 902349 SGTC_2546 rhodinyl acetate 100 µM -1.35981753565697 0.0965793583315743 no 3075 0.0869438359117612 4355 6708682 SGTC_111 0083-0039 52.457 µM -1.36893830074132 0.0950966890471299 no 3076 0.0855092810610212 4362 759313 SGTC_2940 9060638 45.86 µM -1.37208086465099 0.0945897376540899 no 3077 0.0850191328349541 4412 4027022 SGTC_626 0214-0009 33 µM -1.3724072986124 0.0945371924904309 no 3078 0.0849683396481761 4471 3437874 SGTC_1387 3342-1166 1.8 µM -1.37632074554855 0.0939089304388064 no 3079 0.0843611764377307 4395 3418228 SGTC_418 lividomycin a 100 µM -1.37746789221919 0.093725353637346 no 3080 0.084183817510729 4438 72394 An antibiotic. SGTC_1489 4065-0444 182 µM -1.37880044788981 0.09351243879834 no 3081 0.083978144296149 4433 2877968 SGTC_965 1291-5240 308 µM -1.38039986997897 0.0932573561710547 no 3082 0.0837317801001844 4415 2834598 SGTC_214 4373-3496 70 µM -1.38170428354973 0.0930497036689166 no 3083 0.0835312593047087 4516 3779166 SGTC_1210 3013-0140 750 nM -1.38335423005426 0.0927875348070207 no 3084 0.0832781386826634 4443 905973 SGTC_1378 2093-0007 380 nM -1.38495424308073 0.0925338222122077 no 3085 0.0830332295783447 4464 3618014 SGTC_2324 6149169 200 µM -1.38638061942451 0.0923080760551633 no 3086 0.0828153555788718 4361 2888231 SGTC_1793 st048256 72.231 µM -1.38750493432429 0.0921304232604187 no 3087 0.0826439237765464 4381 672022 SGTC_668 1682-0499 62.6 µM -1.38758314547802 0.0921180745529983 no 3088 0.0826320083429113 4422 682214 SGTC_2506 ethyl hematommate 54.16 µM -1.39168232807385 0.0914725712823108 no 3089 0.082009307999688 4463 3940691 An allergen. SGTC_2822 7994718 71.43 µM -1.39369285381929 0.0911571994467862 no 3090 0.0817051875637495 4430 1018011 SGTC_1874 staurosporine 7.6 µM -1.39387421084138 0.0911287914113654 no 3091 0.0816777966104642 4435 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3022 9087993 49.47 µM -1.40508913272863 0.089384800426489 no 3092 0.0799973876070321 4515 17173644 SGTC_810 3825-7150 143 µM -1.40531381809114 0.0893501159089703 no 3093 0.0799639905791552 4470 22330411 YGL099W LSG1 SGTC_1498 4478-3555 97.6 µM -1.40670539969249 0.0891355214662922 no 3094 0.0797573819635998 4427 3437919 SGTC_2008 4012253 172 µM -1.41221923987861 0.0882890075698213 no 3095 0.0789427085536126 4429 603940 SGTC_248 streptozotocin 5.23457 mM -1.41355779667979 0.0880844120009991 no 3096 0.0787458900786347 4466 5300 DNA alkylating agent. SGTC_1919 st067113 52.3 µM -1.41417609938156 0.0879900251805418 no 3097 0.0786551018392006 4438 1268243 SGTC_1941 st076221 61.8 µM -1.42367683133275 0.0865491624896288 no 3098 0.0772700217500517 4325 2828568 SGTC_1558 st069300 45.6 µM -1.42390465390357 0.086514829206431 no 3099 0.0772370372235547 4397 24208000 SGTC_1141 3253-0389 52.6 µM -1.42402683768787 0.0864964200790821 no 3100 0.0772193516618339 4435 5402031 SGTC_113 0099-0221 2.5 µM -1.42451991588649 0.0864221589664292 no 3101 0.0771480120363151 4421 89219 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.4247458432263 0.0863881486187637 no 3102 0.0771153411128866 4521 4620898 SGTC_2211 7117706 200 µM -1.42524898954873 0.0863124426149242 no 3103 0.0770426198594239 4388 822771 SGTC_2616 abietic acid 100 µM -1.4262302398062 0.08616494136768 no 3104 0.0769009467559812 4481 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1058 3448-5425 97.3 µM -1.43044171310743 0.085534014802818 no 3105 0.0762951417130924 4401 7279705 SGTC_1035 k081-0041 55.2 µM -1.43208343314896 0.0852890058775107 no 3106 0.076059972553101 4467 731709 SGTC_81 0411-0046 9.971 µM -1.43280660746323 0.085181246914927 no 3107 0.0759565562713635 4445 12925265 SGTC_1276 0871-0068 94.2 µM -1.43867052298022 0.0843112395937866 no 3108 0.0751219473896511 4476 3414906 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.44399049728311 0.0835277194987138 no 3109 0.0743708242020913 4465 6728940 SGTC_1271 0832-2808 169 µM -1.44494577706227 0.0833876082785067 no 3110 0.074236558368369 4499 3663794 SGTC_1681 tripelennamine 100 µM -1.45103495359743 0.0824986557893629 no 3111 0.0733850636922882 4367 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1322 1348-1070 12 µM -1.45782032241427 0.0815164922467372 no 3112 0.072445037576296 4465 6758089 SGTC_2652 actinonin 100 µM -1.45926972462483 0.0813078428496178 no 3113 0.0722454423884728 4516 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_506 n9-isopropylolomoucine 153 µM -1.45961044130174 0.0812588533513392 no 3114 0.072198583998848 4463 6610355 SGTC_779 1360-0071 233 µM -1.46524409935226 0.0804520502576304 no 3115 0.071427165933192 4503 7566 SGTC_3211 9128781 49.47 µM -1.46645723763054 0.0802791098616413 no 3116 0.0712618814143597 4410 17194361 SGTC_2694 st077685 81.9 µM -1.46964011886727 0.0798267060163348 no 3117 0.0708296242891642 4404 2838096 SGTC_505 gw-5074 63.9 µM -1.47369175305264 0.0792536133965159 no 3118 0.0702823021593077 4501 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2059 5238311 157 µM -1.47717565915867 0.0787633197963851 no 3119 0.0698142783641399 4444 703021 SGTC_989 1501-0895 10.3 µM -1.47798321160186 0.0786500009293668 no 3120 0.0697061359505177 4454 2830112 SGTC_204 PMA1.184 62.41 µM -1.47836836928375 0.0785959976592372 no 3121 0.0696546034619786 4450 2252213 YGL008C PMA1 SGTC_2720 fluspirilene 36.88 µM -1.47914734382916 0.0784868629153871 no 3122 0.0695504695728114 4470 3396 An atypical antipsychotic. SGTC_2355 9061122 103.12 µM -1.4793052324958 0.0784647566389149 no 3123 0.0695293775183163 4489 5302957 SGTC_3260 9137109 49.47 µM -1.48446760110352 0.0777445616257241 no 3124 0.068842456098292 4455 17478346 SGTC_2069 5228469 200 µM -1.48534964687748 0.0776220121324306 no 3125 0.0687256133910652 4486 2835210 SGTC_2073 5212005 126 µM -1.49044079739061 0.076917523634745 no 3126 0.0680541860543441 4391 691789 SGTC_1474 0330-0125 5.35 µM -1.49066238616893 0.0768869720046093 no 3127 0.0680250780628099 4553 X1474 SGTC_1300 1094-0077 113 µM -1.4936673507203 0.0764735717716639 no 3128 0.0676312930997318 4460 5532636 SGTC_2492 derrusnin 100 µM -1.49367928338761 0.0764719335431751 no 3129 0.0676297329040209 4510 1715307 Part of coumarin class of compounds. SGTC_2481 5478948 45.16 µM -1.49747868783232 0.0759516720620999 no 3130 0.0671343734999529 4488 77792 SGTC_2912 7964298 10.93 µM -1.5019276189414 0.0753459000104139 no 3131 0.0665579014426941 4490 2975850 SGTC_211 3455-0679 143.504 µM -1.50982187004008 0.0742800837742172 no 3132 0.0655444414913653 4488 748649 SGTC_1393 3470-5649 58.2 µM -1.51026887203747 0.0742200794752594 no 3133 0.0654874155640739 4496 4108395 SGTC_1027 k015-0025 8.67 µM -1.5217060633932 0.0726973435126325 no 3134 0.0640413738281671 4479 3598955 SGTC_1209 2323-2347 50.3 µM -1.52413188290985 0.0723774693092083 no 3135 0.0637378848232651 4520 5412760 SGTC_2769 toremifene 3.73 µM -1.53389414086829 0.0711010891506262 no 3136 0.0625278488296492 4513 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1760 st045453 10.4495 µM -1.53413086486342 0.0710703543898378 no 3137 0.0624987307528995 4524 3323419 YIL048W NEO1 SGTC_1453 4237-0541 195 µM -1.53433189474623 0.0710442619410696 no 3138 0.0624740115083121 4514 739892 SGTC_744 1594-0068 283 µM -1.53535522299572 0.0709115542251358 no 3139 0.0623482981055604 4502 668392 SGTC_829 1635-0120 117 µM -1.53810214501014 0.0705562682680945 no 3140 0.0620118208124922 4499 285054 SGTC_3006 9075424 71.4286 µM -1.54335071905448 0.0698812262896442 no 3141 0.061372851912993 4478 7465181 SGTC_586 0957-0265 8.15 µM -1.54690668353547 0.0694267100195494 no 3142 0.0609428745968623 4431 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1117 retinoic acid 1.10837 µM -1.55175515579094 0.0688106608150072 no 3143 0.0603604098724735 4554 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1208 2323-2347 50.3 µM -1.55335933112506 0.0686077641205057 no 3144 0.0601686565602174 4533 5412760 SGTC_1054 3429-0080 167 µM -1.55467865141144 0.0684412420571783 no 3145 0.0600113107485532 4529 1162877 SGTC_1112 tnp00069 1.16933 µM -1.56060673304542 0.0676968568913712 no 3146 0.0593082845804055 4492 145826 SGTC_469 w7 172 µM -1.56092213667178 0.0676574278012439 no 3147 0.059271061767097 4621 45115570 A P450 inhibitor. SGTC_1084 voriconazole 435 nM -1.5637035738362 0.0673104838025294 no 3148 0.0589435990390458 4551 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.56386512300674 0.0672903752218907 no 3149 0.0589246233187652 4471 6708739 YPR165W RHO1 SGTC_470 aa-861 153 µM -1.56489139538857 0.0671627400133168 no 3150 0.0588041883015492 4475 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1842 st055362 61.2 µM -1.56716293407867 0.0668808995986594 no 3151 0.0585383059412046 4484 676032 SGTC_1568 digitonin 820 nM -1.56743259411156 0.0668475024654592 no 3152 0.0585068051595891 4506 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_76 0433-0009 400.328 µM -1.56837028217994 0.0667314711405561 no 3153 0.0583973711840424 4573 2841569 SGTC_2941 9056145 11.23 µM -1.56869461936178 0.0666913733307231 no 3154 0.0583595564767798 4482 2119517 SGTC_1358 1509-0022 2.48 µM -1.57132774657973 0.0663665296146405 no 3155 0.058053269710524 4558 3258434 SGTC_3003 9075612 71.4286 µM -1.57219717262725 0.0662595397174406 no 3156 0.0579524154835654 4548 6501993 SGTC_2372 9071633 200 µM -1.57386515305974 0.0660546552710415 no 3157 0.0577593137880683 4572 21321366 SGTC_3097 9117246 49.47 µM -1.58246897830695 0.0650056009962925 no 3158 0.0567712743635055 4560 16423892 SGTC_1752 st044819 83.042 µM -1.58501831153145 0.0646972603054683 no 3159 0.0564810869312933 4490 441209 YML126C ERG13 SGTC_2653 dihydrofissinolide 100 µM -1.58569843169581 0.0646151923140215 no 3160 0.0564038675554779 4596 6857746 SGTC_3063 1327-0034 4 µM -1.58709180603982 0.0644473106945102 no 3161 0.056245926717012 4427 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_805 3852-0218 479 µM -1.58889498592696 0.0642305566822416 no 3162 0.0560420516989869 4521 6615355 SGTC_549 1661-1316 519 µM -1.59152923708523 0.0639149215215739 no 3163 0.0557452604995968 4556 2857282 SGTC_3278 9139605 49.47 µM -1.59918351400827 0.063004630953794 no 3164 0.0548899161792049 4526 7958859 SGTC_607 4491-0986 66.8 µM -1.59948542597787 0.0629689339472588 no 3165 0.0548563921797912 4542 698981 YDR232W HEM1 SGTC_1762 st045503 25.4615 µM -1.61943782705911 0.0606445699305424 no 3166 0.0526765467435352 4581 4645554 SGTC_715 0868-0130 184 µM -1.61958643621428 0.0606275129311795 no 3167 0.052660572599203 4602 2876258 SGTC_528 3492-0019 172 µM -1.62464228118285 0.0600494478704188 no 3168 0.0521194012365654 4554 2869262 SGTC_667 1498-1044 59 µM -1.62625473566936 0.0598659967992172 no 3169 0.0519477382729201 4542 6739982 SGTC_64 000l-0018 272.079 µM -1.62844612718063 0.0596173833617858 no 3170 0.0517151617974767 4477 6811119 SGTC_1501 4491-0275 38.4 µM -1.6284950432611 0.0596118430765859 no 3171 0.0517099797023983 4566 5104718 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.62968914505833 0.0594767229902423 no 3172 0.0515836063566713 4561 7104 SGTC_1856 st057054 55.7 µM -1.63065890765997 0.0593671650371994 no 3173 0.0514811559181933 4528 1266018 SGTC_707 0865-0008 204 µM -1.63105789492834 0.0593221358169366 no 3174 0.0514390519739917 4613 723043 SGTC_749 1000-0129 128 µM -1.63562068802444 0.0588090866924825 no 3175 0.0509594989216951 4578 708470 SGTC_381 3461-2219 42.7 µM -1.6361373282402 0.0587512148195256 no 3176 0.0509054246693525 4541 2883159 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.63964808941747 0.0583591371278457 no 3177 0.0505391790422116 4578 5024745 SGTC_1143 3454-2408 5.08 µM -1.6420415578306 0.0580930175659518 no 3178 0.0502906959472355 4561 X1143 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.64377296806528 0.0579011045273332 no 3179 0.0501115535398212 4534 1241132 A phosphatase inhibitor. SGTC_1214 0358-0031 63.7 µM -1.64380920277701 0.057897093528395 no 3180 0.0501078099146178 4573 4301366 SGTC_2905 7799065 20.05 µM -1.64423727942264 0.0578497241437244 no 3181 0.0500635996263044 4451 1296806 SGTC_325 2810-4341 181 µM -1.64634625871392 0.0576167969159251 no 3182 0.0498462453478919 4563 774970 SGTC_3109 9122853 49.47 µM -1.6465702671189 0.0575920995949611 no 3183 0.049823203025293 4587 1234709 SGTC_1765 st044815 90.4 µM -1.6491594324842 0.0573072434694982 no 3184 0.0495574882356023 4574 645695 SGTC_292 k038-0015 474 µM -1.6545643659531 0.0567161743194107 no 3185 0.0490064483882877 4559 46368540 SGTC_2009 4012297 12.05 µM -1.65485386465414 0.05668465151722 no 3186 0.0489770722960354 4524 45595307 SGTC_1893 st059353 36.1 µM -1.65929604122164 0.0562026825974256 no 3187 0.0485280763065191 4571 3112488 SGTC_1635 st007035 42.4 µM -1.66228771561892 0.055879915679662 no 3188 0.0482275498476754 4526 3716403 SGTC_739 1486-1183 203 µM -1.66288640402613 0.0558155001008852 no 3189 0.0481675882150241 4565 4346692 SGTC_1552 6-methylflavone 10.6 µM -1.66482683207025 0.0556071233298565 no 3190 0.0479736545455746 4527 689013 SGTC_37 0566-0070 1.56 µM -1.66861520314178 0.0552020714930948 no 3191 0.0475968319665576 4502 1626686 SGTC_315 k915-0449 187 µM -1.67107555598643 0.0549402617866239 no 3192 0.0473533774405771 4606 20970215 YNL149C PGA2 SGTC_1411 3909-8223 150 µM -1.67448420330814 0.0545791652989019 no 3193 0.0470177382027525 4614 X1411 SGTC_1831 st055328 12 µM -1.67473410491409 0.0545527658821448 no 3194 0.0469932063882524 4568 1103068 SGTC_2058 5236698 133 µM -1.67510987495689 0.0545130888281114 no 3195 0.0469563379073762 4550 766665 SGTC_716 1683-5115 658 µM -1.67792771819583 0.0542162833696504 no 3196 0.0466806053252594 4580 723597 SGTC_2051 5263410 176 µM -1.67896608212621 0.0541072347215039 no 3197 0.0465793271278975 4543 227584 SGTC_1921 5740136 50 µM -1.68364263571823 0.0536182545201047 no 3198 0.0461253768538727 4520 1774243 SGTC_1975 st070967 30.8 µM -1.68536259032655 0.0534392991128181 no 3199 0.0459593183190529 4580 261391 SGTC_1491 4138-0063 26.5 µM -1.68606813047103 0.0533660271028705 no 3200 0.0458913387613008 4608 23883227 SGTC_100 0086-0128 49.5915 µM -1.68660659560381 0.0533101598169348 no 3201 0.0458395114433506 4575 93297 SGTC_454 lyso-paf C-16 6.67 µM -1.68679213042086 0.0532909207946038 no 3202 0.0458216645998786 4587 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_209 4077-0173 175.592 µM -1.69578054080742 0.0523654417085278 no 3203 0.044963724497124 4561 15993494 SGTC_386 1509-0011 3.07 µM -1.7030765182532 0.0516236434981384 no 3204 0.0442768748380715 4597 3107280 SGTC_1332 1480-0653 17.5 µM -1.70605745195438 0.0513229797508656 no 3205 0.0439986916846725 4600 5749438 SGTC_3145 9085516 49.47 µM -1.7122499840545 0.0507028401437241 no 3206 0.0434253048083657 4573 25236195 SGTC_1317 1273-0028 910 nM -1.7229395310579 0.0496464107465116 no 3207 0.0424497303327153 4609 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_587 k089-0003 57 µM -1.72592997337527 0.0493540359791399 no 3208 0.0421800058017334 4534 9659696 SGTC_1626 st003712 1.76 µM -1.7295921436348 0.0489978608805669 no 3209 0.0418515853487886 4595 24207035 SGTC_1700 st030840 7.9285 µM -1.7325422532068 0.0487124352690873 no 3210 0.0415885303950855 4641 5499307 SGTC_150 3970-0969 77.2 µM -1.7344379901478 0.0485297235872436 no 3211 0.0414201996617353 4603 6615640 SGTC_2853 9015042 58.44 µM -1.73870814814328 0.0481201717295788 no 3212 0.0410430560330599 4529 6457456 SGTC_811 0416-0114 265 µM -1.74004498117089 0.0479925257436285 no 3213 0.0409255599632941 4603 6612453 SGTC_1747 st037496 66.6 µM -1.74181776522258 0.0478236716200987 no 3214 0.0407701685454725 4568 723305 SGTC_774 k060-0086 136 µM -1.74725429518453 0.0473088173803309 no 3215 0.0402966186586981 4598 5911235 SGTC_29 0299-0004 12.984 µM -1.74834179065946 0.0472063636771694 no 3216 0.0402024304339967 4541 16871 A napthoquinone isolated from Swertia calycina. SGTC_701 4424-0219 185 µM -1.75210451114264 0.0468532467414671 no 3217 0.0398779193630473 4611 2911779 SGTC_52 0329-0193 875 nM -1.75342645472188 0.0467296914824284 no 3218 0.0397644166727426 4629 3739292 SGTC_843 0310-0051 143 µM -1.76987860534544 0.0452137616684232 no 3219 0.0383736827967778 4630 2065037 SGTC_909 3448-9333 149 µM -1.77372913132069 0.0448647433138508 no 3220 0.0380539827030097 4544 3344074 SGTC_2458 5808907 16.39 µM -1.77709208656574 0.0445616966687672 no 3221 0.0377765449847337 4703 2731747 SGTC_1562 morin hydrate 59.1 µM -1.78133333970911 0.0441818573338417 no 3222 0.0374290055263466 4615 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_433 pimozide 108 µM -1.78474305334264 0.0438783855578888 no 3223 0.037151502037469 4546 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1555 citronellol 128 µM -1.79232104301287 0.0432099480570078 no 3224 0.036540777198208 4611 8842 A terpine precursor. SGTC_1927 st060202 13.8 µM -1.79988165585909 0.0425512632042723 no 3225 0.0359396633967847 4571 688887 SGTC_1057 3448-5381 134 µM -1.80605521065664 0.0420194620561462 no 3226 0.0354548580088012 4620 5497911 SGTC_2831 7999036 19.48 µM -1.80776104595245 0.0418734708163164 no 3227 0.0353218494565681 4590 2988270 SGTC_2785 7756463 72.73 µM -1.81170660426296 0.0415373697033102 no 3228 0.0350157713160519 4607 2201551 SGTC_2597 laccaic acid a 100 µM -1.81277899118489 0.04144639752093 no 3229 0.0349329577566859 4586 5491415 A textile dye. SGTC_2893 9048488 25.97 µM -1.82241605781948 0.0406360958496186 no 3230 0.0341959399514477 4657 6467338 SGTC_168 3970-0862 530.542 µM -1.82951452881958 0.0400475054138293 no 3231 0.0336612824119296 4554 3135186 SGTC_806 3966-4455 5.86 µM -1.83818659539207 0.0393378568326629 no 3232 0.0330174571675589 4635 714982 SGTC_741 4582-0002 126 µM -1.84490833952691 0.0387948738291837 no 3233 0.0325254366712232 4656 2912688 SGTC_2294 7971431 200 µM -1.84491632802878 0.0387942321680597 no 3234 0.0325248555442781 4624 5741572 SGTC_1827 berberine 7.24 µM -1.8495227786409 0.0384256650337441 no 3235 0.0321911808772159 4570 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1245 0418-0076 17.2 µM -1.85161049114217 0.0382595673854596 no 3236 0.0320408877271578 4639 6790114 SGTC_994 3910-0338 138 µM -1.85973253314 0.0376189413169033 no 3237 0.0314616883986374 4663 3479481 SGTC_2079 5212404 121 µM -1.86071703417569 0.0375418873987066 no 3238 0.0313920735147545 4604 758462 SGTC_975 1335-0046 28.5 µM -1.86971392183118 0.0368436821209572 no 3239 0.0307617775978753 4636 16486740 SGTC_2497 7-hydroxyflavone 100 µM -1.87925336720013 0.0361150062746536 no 3240 0.0301049529028405 4644 5281894 SGTC_2751 anetholtrithion 17.25 µM -1.88695884118455 0.0355350727401696 no 3241 0.0295829309051715 4603 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3264 9137442 49.47 µM -1.89433353522197 0.0349872064217295 no 3242 0.0290903762200032 4617 17015726 SGTC_567 1080-0542 68.4 µM -1.90992807637465 0.0338515047995887 no 3243 0.028071237252833 4573 5950415 SGTC_1651 st011928 86.1 µM -1.91839602016397 0.0332476266843021 no 3244 0.0275304076582864 4663 720198 SGTC_3281 9140613 49.47 µM -1.91870795685229 0.0332255519611209 no 3245 0.0275106519820086 4647 16013766 SGTC_3070 9117005 49.47 µM -1.92554623308227 0.0327446552498104 no 3246 0.0270805289029852 4721 8779016 SGTC_875 0709-0210 25.7 µM -1.92707480795546 0.0326379478662029 no 3247 0.026985153878641 4657 6251364 SGTC_2216 7189485 200 µM -1.93610001170001 0.032013743101122 no 3248 0.026427726555213 4701 731273 SGTC_1422 4031-0024 15.5 µM -1.93989690229152 0.031754103294193 no 3249 0.026196110316663 4637 782427 SGTC_1410 3909-8106 77.9 µM -1.94075861417754 0.0316954203899529 no 3250 0.0261437815305425 4707 1039210 SGTC_12 0849-0099 9.267 µM -1.94172708036525 0.0316295744579191 no 3251 0.0260850742793335 4658 6071388 SGTC_2932 9016711 44.54 µM -1.95282070734629 0.0308833524396245 no 3252 0.0254204219767218 4641 7117328 SGTC_894 0960-0238 55.9 µM -1.95791944098737 0.0305453021716037 no 3253 0.0251197331463321 4667 6741907 YDL195W SEC31 SGTC_2851 9015922 71.43 µM -1.98375128489305 0.0288794010137024 no 3254 0.0236417866380952 4665 2996893 SGTC_32 0928-0142 34.1 µM -1.988170806971 0.0286020929524706 no 3255 0.0233964012304756 4691 2244242 SGTC_1728 st035614 33.7865 µM -1.98923196509321 0.0285358400977615 no 3256 0.0233378026095364 4637 15945546 SGTC_2290 7904846 200 µM -1.99006610683702 0.0284838505522973 no 3257 0.0232918268976792 4699 2962154 SGTC_1570 verbenone 133 µM -1.99086658958292 0.0284340329911191 no 3258 0.0232477780856976 4676 29025 A natural terpanoid with antifungal properties. SGTC_970 1315-0089 19.5 µM -1.9914462412368 0.0283980039921644 no 3259 0.0232159249159132 4666 6811083 YLR033W RSC58 SGTC_2897 9048598 12.99 µM -1.99206023481808 0.028359881864643 no 3260 0.0231822246574469 4662 6467404 SGTC_2303 7774051 200 µM -1.99290866242428 0.0283072740995576 no 3261 0.023135724803197 4668 2953184 SGTC_1808 st050063 61.5 µM -2.00492868552576 0.0275706443643888 no 3262 0.022485335768942 4660 4011993 SGTC_2161 5662504 8.5105 µM -2.0081516642432 0.0273758680116592 no 3263 0.0223135887939094 4697 2859334 SGTC_2519 cryptotanshinone 88.04 µM -2.0222712434565 0.0265360462072187 no 3264 0.02157416886273 4687 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2353 9059630 146.67 µM -2.02653228660987 0.0262868712180396 no 3265 0.0213551337961253 4710 4779114 SGTC_876 0720-0963 56.8 µM -2.03391606043288 0.0258597188137477 no 3266 0.0209800296891128 4691 765861 SGTC_229 benomyl 22.8748 µM -2.04307599730918 0.025337901775799 no 3267 0.0205224577872836 4714 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1878 temozolomide 1 mM -2.04319627949029 0.0253311087368968 no 3268 0.0205165059538023 4666 5394 DNA alkylating agent. SGTC_404 fumagillin 50 µM -2.0575340959746 0.02453222786683 no 3269 0.0198174393348085 4699 12015870 A methionine aminopeptidase binder. SGTC_1033 k072-0102 21.3 µM -2.06713977624225 0.0240089293993697 no 3270 0.0193604924986346 4662 5965931 SGTC_1171 0368-0077 21.4 µM -2.06744154908525 0.0239926425609501 no 3271 0.0193462832836585 4688 3239779 SGTC_2457 5731572 11.68 µM -2.06759968106913 0.0239841118027171 no 3272 0.0193388410520694 4715 2865357 SGTC_1129 3453-1384 223 µM -2.07100542098564 0.0238009997825844 no 3273 0.0191791447296266 4663 1084452 SGTC_99 0109-0120 622.8 µM -2.08703922880532 0.0229546473716434 no 3274 0.0184422943188128 4701 759414 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -2.09928119103981 0.0223256437525381 no 3275 0.0178960602370027 4688 688798 SGTC_2037 5169046 200 µM -2.10197075713688 0.0221894168180894 no 3276 0.0177779187544097 4736 5718022 SGTC_2354 9060492 162 µM -2.11030253431841 0.021771855298152 no 3277 0.017416152723687 4703 6471895 SGTC_2395 5646831 180.19 µM -2.11299693853433 0.0216382488931778 no 3278 0.0173005149578237 4652 6808628 SGTC_620 0109-0052 432 µM -2.1284320796403 0.0208861543147061 no 3279 0.0166506378703978 4730 493037 SGTC_838 0109-0203 71.4 µM -2.1302383927816 0.0207996035296162 no 3280 0.0165759684396432 4723 759422 SGTC_1928 4'-methoxychalcone 40.3 µM -2.13282301749465 0.0206762876511037 no 3281 0.0164696236575067 4695 641818 SGTC_1650 st011916 45.8 µM -2.15051333332432 0.0198487732938331 no 3282 0.0157573162370505 4705 242528 SGTC_2724 maprotiline 69.64 µM -2.18206479241379 0.0184425768129911 no 3283 0.0145523755901067 4671 4011 A tricyclic antidepressant. SGTC_1756 st041558 35.5 µM -2.18231510810697 0.0184317690120385 no 3284 0.0145431423698209 4756 3955792 SGTC_257 daunorubicin 18.5 µM -2.18595423803426 0.0182752517312125 no 3285 0.014409476749127 4736 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3158 9100007 49.47 µM -2.19412207044319 0.0179280758726172 no 3286 0.0141133175032626 4725 19297233 SGTC_2545 solidagenone 89.61 µM -2.20275680437637 0.0175671858758092 no 3287 0.0138059470917954 4731 6708572 An anti ulcer agent SGTC_2816 7982706 58.44 µM -2.24513650918935 0.0158845251525693 no 3288 0.0123796852353586 4697 2981853 SGTC_2799 7812892 81.82 µM -2.26068309881166 0.0153028908468076 no 3289 0.0118894438984329 4729 20205235 SGTC_1040 k898-0338 155 µM -2.2644077599042 0.015166290139888 no 3290 0.0117745235710747 4714 20969351 SGTC_1978 st071761 42 µM -2.288924988368 0.0142930115105479 no 3291 0.0110418555502637 4746 5147680 SGTC_236 1509-0011 5.31 µM -2.29407186199999 0.0141152889075488 no 3292 0.0108931856535182 4735 3107280 SGTC_1014 4130-3005 69.3 µM -2.29937856799362 0.0139340443887402 no 3293 0.010741725934598 4734 743608 SGTC_1815 st051655 58.2 µM -2.30003055442397 0.0139119155374082 no 3294 0.0107232445357663 4731 5984156 SGTC_2164 5685496 200 µM -2.32213701739675 0.0131793300833382 no 3295 0.0101127795051053 4731 759046 SGTC_2177 5811945 192 µM -2.32323265380336 0.0131439054219973 no 3296 0.0100833287387938 4718 5343475 SGTC_212 3807-4682 38.772 µM -2.33046232857554 0.0129122084791718 no 3297 0.00989086441846043 4766 3125501 YBL034C STU1 SGTC_50 0929-0078 56.389 µM -2.34813090699636 0.0123607763140336 no 3298 0.00943394437502198 4664 1377751 SGTC_2328 6201408 200 µM -2.35602900507371 0.0121209511354875 no 3299 0.00923573767080339 4709 2890418 SGTC_1702 st027038 51 µM -2.38985668705566 0.0111388516766535 no 3300 0.00842747418205274 4778 5521182 SGTC_1725 st036284 20.55 µM -2.39006679467289 0.0111329746188967 no 3301 0.00842265442859689 4730 707914 SGTC_129 0088-0017 176.636 µM -2.40498564828954 0.0107225037933589 no 3302 0.00808655045967835 4657 182446 SGTC_319 1348-1596 45.5 µM -2.40803318554825 0.0106402953352937 no 3303 0.00801936152164812 4778 5380505 SGTC_101 0490-5701 117.494 µM -2.41832675206469 0.0103666676615885 no 3304 0.00779603423477556 4691 4661669 SGTC_2373 9071805 200 µM -2.42085616282756 0.0103003762454616 no 3305 0.00774200134100793 4752 10149009 SGTC_2282 7944268 200 µM -2.42380158863609 0.0102236478998501 no 3306 0.00767949716892534 4731 2970414 SGTC_851 0394-0702 453 µM -2.42998316716508 0.0100642371305117 no 3307 0.00754976204178596 4749 762646 SGTC_536 3852-0578 10.6 µM -2.4347277953303 0.00994335805872662 no 3308 0.00745149803246207 4750 2869208 SGTC_2649 anisomycin 9.56 µM -2.44274088662505 0.00974208491718098 no 3309 0.00728809920522109 4776 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_943 3253-1379 105 µM -2.44449934595165 0.00969839515096535 no 3310 0.00725266719011431 4731 668464 SGTC_2714 st079313 56.9 µM -2.47554672271775 0.00895472187969521 no 3311 0.00665161769816962 4758 2939799 SGTC_2113 5491891 107.031 µM -2.482671910728 0.00879127466286095 no 3312 0.00652005648504719 4752 789979 SGTC_592 k241-0073 46.5 µM -2.5207167714029 0.0079620683121107 no 3313 0.00585580384950541 4786 4230158 SGTC_1795 st049545 62.3 µM -2.52618690402231 0.00784868298474761 no 3314 0.00576540588862348 4756 5291882 SGTC_2591 skatole 100 µM -2.534107016901 0.00768703186021044 no 3315 0.00563671484756339 4728 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2885 9057732 51.95 µM -2.5360523524969 0.00764777830968488 no 3316 0.00560549863470865 4764 6471414 SGTC_2819 7996655 46.38 µM -2.54402628128724 0.0074887162460335 no 3317 0.0054791419621923 4750 6456960 SGTC_533 1222-0222 6.71 µM -2.57886260290118 0.00682748706477905 no 3318 0.0049563102399881 4776 3982874 SGTC_2039 Aminomethylbenzodioxan 200 µM -2.58626179650945 0.00669387315942854 no 3319 0.00485116034075537 4781 15053 SGTC_1758 st042942 75.2445 µM -2.59849120219145 0.00647809763355074 no 3320 0.0046817222203517 4757 669317 SGTC_808 0711-0032 135 µM -2.66148823393092 0.00546120834173887 no 3321 0.00388980299243403 4765 4252555 SGTC_696 1560-0013 611 µM -2.66828906117055 0.00536039875162848 no 3322 0.00381193172777211 4779 1650269 SGTC_1142 3253-1408 9.78 µM -2.70012155045914 0.00491020831590248 no 3323 0.0034657073414614 4762 256655 SGTC_1922 5578187 25 µM -2.78316902149945 0.00389024840809476 no 3324 0.00269153773499499 4772 1350412 SGTC_1059 3448-6867 171 µM -2.79426540960173 0.00376943226993799 no 3325 0.00260088833494892 4770 3934407 SGTC_2325 6158266 200 µM -2.81782537707953 0.00352400367225573 no 3326 0.00241750488437015 4763 3623240 SGTC_156 3474-0145 5.642 µM -2.87528985012118 0.00298448998041258 no 3327 0.00201828376650344 4760 2265471 SGTC_1600 coumarin 106 71.1 µM -2.89134760694989 0.00284766344287973 no 3328 0.00191796789750281 4792 100336 A hepatotoxic, DNA x-linker. SGTC_2929 9013348 24.6 µM -2.91379812656607 0.00266584647052853 no 3329 0.00178530360719355 4770 2995952 SGTC_2683 piperine 63.03 µM -2.93319659362783 0.0025172623332879 no 3330 0.00167745691443739 4801 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_153 4077-0274 519.67 µM -2.95760051594077 0.00234098929603259 no 3331 0.00155021822832625 4780 3121976 SGTC_912 3474-0017 2.18 µM -2.97599928883534 0.00221556547904066 no 3332 0.0014601776961022 4783 3360550 SGTC_2166 5933061 31.504 µM -2.97773592534834 0.00220404720030251 no 3333 0.00145193029970256 4756 2877375 SGTC_2141 5621638 7.665 µM -3.01838872759568 0.00194945896076736 no 3334 0.00127061352591299 4793 2856238 SGTC_2913 7966556 36.57 µM -3.03384284571382 0.00185990369292206 no 3335 0.00120730088200298 4760 2976516 SGTC_1715 st032160 10.2275 µM -3.0340288152247 0.00185884916893759 no 3336 0.00120655690049017 4741 5289825 SGTC_1991 st073000 8.92 µM -3.05555873058091 0.00174037652002608 no 3337 0.00112320800988803 4796 4301969 YIL048W NEO1 SGTC_1298 1079-1278 263 µM -3.05996348371362 0.00171700210121208 no 3338 0.00110681989750964 4790 2840950 SGTC_3032 9089427 49.47 µM -3.15605204481525 0.00127317835632875 no 3339 0.000799601612907942 4777 17173707 SGTC_3306 9127676 59.7925 µM -3.15908037359623 0.00126107408099565 no 3340 0.000791339181524211 4779 41905287 SGTC_2015 5119600 184 µM -3.18290333484139 0.00116946283015353 no 3341 0.000729031416057325 4781 2828786 SGTC_2159 5658611 73.75 µM -3.31512926733429 0.000762739873315309 yes 3342 0.000458003774389066 4798 793844 SGTC_1008 4106-0037 6 µM -3.35092474485371 0.000677665964651144 yes 3343 0.000402710935554094 4804 2905394 SGTC_2805 7950783 58.44 µM -3.48080013314099 0.000437190242858311 yes 3344 0.000249959190500998 4792 1178958 YDL195W SEC31 SGTC_2701 st077767 14.721 µM -3.48135567284998 0.000436357845635114 yes 3345 0.000249441278526066 4796 5721188 SGTC_2487 5918373 44.05 µM -3.49064221486476 0.00042265907558848 yes 3346 0.000240930539700127 4798 2876279 SGTC_2337 9009472 200 µM -3.55210336805045 0.000341585556799678 yes 3347 0.000191082348507519 4782 5742383 SGTC_1023 4482-3888 16 µM -3.55532732739923 0.00033776061173819 yes 3348 0.000188754404189263 4791 3303168 SGTC_180 1486-1293 102.781 µM -3.61680157462045 0.000272028948203244 yes 3349 0.000149132885362366 4795 4140536 SGTC_534 k292-0788 63.4 µM -3.64563635566173 0.0002454938039815 yes 3350 0.00013336546834924 4805 4146317 SGTC_1007 4101-0031 70 µM -3.65053859814593 0.000241230065620989 yes 3351 0.000130845489013543 4806 1146276 SGTC_3221 9128209 49.47 µM -3.94524367878009 8.09944821451194e-05 yes 3352 3.98594336792499e-05 4806 16460723 SGTC_311 1315-0136 58 µM -3.96271566222385 7.57409490732294e-05 yes 3353 3.70510084532689e-05 4808 6759207 SGTC_1011 4112-3381 17.4 µM -4.17632428993945 3.26553840563438e-05 yes 3354 1.48128694341528e-05 4809 2877139 SGTC_2413 inermin 26.06 µM -4.6748968694801 3.92582624666996e-06 yes 3355 1.47050687453402e-06 4805 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2411 st077133 39.94 µM -5.05175544031443 6.85012315484278e-07 yes 3356 2.18883992701133e-07 4806 1403142 YNL221C POP1