SGTCid condition conc unit YOR345C|YOR345C.score YOR345C|YOR345C.strain.pval YOR345C|YOR345C.strain.significant YOR345C|YOR345C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2133 5320837 200 µM 5.23024396902088 8.3049084267899e-08 yes 1 8.46432406724304e-08 8 2841355 SGTC_2551 apiole 73.87 µM 5.09053818991188 1.74766715462019e-07 yes 2 1.7852432455059e-07 3 10659 A possible DNA adduct former. SGTC_735 3076-0345 636 µM 4.87840802124105 5.21818483232791e-07 yes 3 5.34727574730574e-07 14 2888990 SGTC_453 enantio-paf c16 10 µM 4.65796223680049 1.55363476541159e-06 yes 4 1.59677386913924e-06 102 13871343 A lipid and platelet activating factor SGTC_2765 myclobutanil 7.74 µM 4.64493404249576 1.65470194755946e-06 yes 5 1.70092560824102e-06 32 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_545 4218-0007 221 µM 4.44291117594417 4.30662006574624e-06 yes 6 4.43749054591902e-06 15 2840508 SGTC_634 1611-4317 11.2 µM 4.37175990982538 5.97609661770158e-06 yes 7 6.16245076614697e-06 10 2843522 SGTC_2160 5660466 132.927 µM 4.16501948281086 1.50648040543955e-05 yes 8 1.55662988777436e-05 11 2859134 SGTC_1690 st023502 41.2 µM 3.881142144222 5.0192345073505e-05 yes 9 5.19835247455675e-05 9 24207482 SGTC_2816 7982706 58.44 µM 3.79183197287218 7.21493987303297e-05 yes 10 7.47700407508133e-05 56 2981853 SGTC_2528 xanthyletin 44.79 µM 3.78767150851221 7.33659529475399e-05 yes 11 7.60328564983385e-05 26 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2414 st077232 92.9 µM 3.70595936164388 0.000101550742543561 yes 12 0.000105296033405027 27 729801 SGTC_1810 st050138 53 µM 3.70310188441444 0.000102700149436024 yes 13 0.000106489648568055 17 3444541 SGTC_2164 5685496 200 µM 3.62865707789096 0.000137322168950393 yes 14 0.000142449691255121 29 759046 SGTC_1718 roemerine 11.9335 µM 3.62788619452346 0.000137732148213721 yes 15 0.000142875579340647 69 235224 An aporphine alkaloid with mutagenic activity. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 3.55335531072071 0.000183258010995883 yes 16 0.000190175181662888 57 676296 Flavone; oxidizing agent. SGTC_2842 9000675 19.48 µM 3.5329650051295 0.000197970509473324 yes 17 0.000205463430884179 35 2989072 SGTC_2349 9023730 187.07 µM 3.45918367717443 0.000260940342865197 yes 18 0.000270907640469701 51 4126287 SGTC_1098 clofazimine 15.1 µM 3.43505859161542 0.000285285441927378 yes 19 0.000296212862353469 47 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2944 9067346 25.62 µM 3.37498842143411 0.000355393757829981 yes 20 0.000369093982811724 52 6473075 SGTC_1170 0310-0127 64.8 µM 3.32749594718794 0.000421816011514417 yes 21 0.000438151319027922 48 774975 SGTC_1703 st026983 48.3 µM 3.20469961702444 0.000650573103993772 yes 22 0.000676017505926219 33 1104023 SGTC_3013 9080133 71.4286 µM 3.13250627085941 0.00083384324029492 yes 23 0.000866603625248495 58 17050193 SGTC_1448 4255-0083 152 µM 3.08985258164848 0.000963346001031115 yes 24 0.00100127931708252 51 5399660 SGTC_6 0844-0013 19.835 µM 3.08106419615755 0.000992223932513029 yes 25 0.00103131086567077 195 1584900 SGTC_1588 farnesol 29.9 µM 3.07464528091797 0.00101381575896569 no 26 0.00105376524204878 43 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1812 st052057 4.327 µM 3.04326817351906 0.00112569965033113 no 27 0.00117011839242757 70 3645418 SGTC_1059 3448-6867 171 µM 3.01493904029884 0.00123631808644855 no 28 0.00128515454933445 44 3934407 SGTC_628 1636-0253 16 µM 3.00964408694118 0.00125806513038245 no 29 0.00130776992729735 81 4456143 SGTC_759 3486-0358 89.3 µM 2.91599541906008 0.00170523709391233 no 30 0.00177277853296093 63 875103 SGTC_3221 9128209 49.47 µM 2.80632396788866 0.0024099601041367 no 31 0.00250551417670251 71 16460723 SGTC_2336 9001819 198.65 µM 2.80325984440432 0.00243297790712225 no 32 0.0025294446377073 130 2989602 SGTC_1291 0993-0025 5.79 µM 2.79932257960283 0.00246284670140872 no 33 0.00256049750693235 48 4353356 SGTC_3207 9114163 49.47 µM 2.77691407589098 0.00263924573173725 no 34 0.00274388421296658 106 849233 SGTC_1200 1643-0193 18.4 µM 2.76108484749507 0.00277064755119512 no 35 0.0028804853775302 62 5403974 SGTC_1975 st070967 30.8 µM 2.75561531750329 0.00281740574733471 no 36 0.00292909250045391 109 261391 SGTC_536 3852-0578 10.6 µM 2.71315610272524 0.00320528548289951 no 37 0.00333228516549455 88 2869208 SGTC_8 0354-0001 70 µM 2.71152670959053 0.0032210847733825 no 38 0.00334870725143784 174 4993152 SGTC_2752 diclazuril 33.15 µM 2.6903038106856 0.00343336647254313 no 39 0.00356934980618192 231 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1125 tnp00248 1.32998 µM 2.68688083079815 0.00346875798819162 no 40 0.00360613395216932 143 24207736 SGTC_1100 amiodarone 5.07 µM 2.66332529461466 0.00372132523303614 no 41 0.00386862887515926 75 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2136 5328288 199.296 µM 2.65302466404001 0.00383686319023583 no 42 0.00398870207630901 75 262395 SGTC_2036 5160441 105 µM 2.64410932281208 0.00393944747160031 no 43 0.0040953098712963 165 134534 YIL048W NEO1 SGTC_952 1185-0122 232 µM 2.60689044831728 0.00439474616410869 no 44 0.00456842938758525 100 678600 SGTC_1923 st058458 19.1 µM 2.60384060567967 0.00443406163586714 no 45 0.00460928091532578 140 3534982 SGTC_2088 5278280 127.392 µM 2.5972508246695 0.00452008503634289 no 46 0.00469866371639511 129 791502 SGTC_621 3584-0052 32.1 µM 2.59378099340827 0.00456597669063404 no 47 0.00474634667973789 109 2273927 SGTC_1180 1193-0155 285 µM 2.55081051316656 0.0051697545949874 no 48 0.00537363698744241 101 2921347 SGTC_2824 7998404 51.95 µM 2.54984578331398 0.00518408957551934 no 49 0.00538852896970625 119 837851 SGTC_760 0568-0725 82.9 µM 2.54926783312547 0.00519269430584903 no 50 0.00539746801926398 78 3916171 SGTC_450 aminopyrene 156 nM 2.54378324923433 0.00527498545389853 no 51 0.00548295539236733 132 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1134 3477-0009 42.5 µM 2.52526215278945 0.00556151609499491 no 52 0.00578060055128745 155 3973534 SGTC_1369 1866-0067 208 µM 2.5211444038961 0.00562706780439228 no 53 0.00584869187324894 148 3531355 SGTC_374 0880-0231 82.3 µM 2.51408022734818 0.00574112399879993 no 54 0.00596716408290422 115 6833587 SGTC_3160 9100216 49.47 µM 2.51333777062029 0.00575322984990596 no 55 0.00597973844156056 53 17191039 SGTC_2698 st077697 67.5 µM 2.51118784629119 0.00578841251524552 no 56 0.00601628248508669 93 3154499 SGTC_2801 7907800 81.82 µM 2.50958338308976 0.00581479319283177 no 57 0.00604368373402282 139 6620925 SGTC_2806 7952793 58.44 µM 2.49895611742095 0.00599223637101827 no 58 0.00622798670629056 117 2972490 SGTC_1831 st055328 12 µM 2.49638732845761 0.00603584122561003 no 59 0.00627327600330658 129 1103068 SGTC_2353 9059630 146.67 µM 2.47101866007541 0.00648180590103028 no 60 0.0067364394194207 78 4779114 SGTC_1055 3448-0672 86 µM 2.46444761866863 0.00660197208987118 no 61 0.00686123097729761 136 748378 SGTC_2191 5911152 200 µM 2.45679188393241 0.00674445510704143 no 62 0.00700919354415255 110 2875902 SGTC_608 k048-0125 159 µM 2.45301784134692 0.00681568961912263 no 63 0.00708316560881725 108 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_999 SEC7.066 22.7 µM 2.44994123685582 0.00687425098419298 no 64 0.00714397652450422 137 740511 YDR170C SEC7 SGTC_1455 4262-0120 131 µM 2.43980079746795 0.00707042641486339 no 65 0.00734768139954491 144 1529587 SGTC_2446 5162541 200 µM 2.43218199095972 0.00722105251791563 no 66 0.00750408211053107 88 1549321 SGTC_3142 9086498 49.47 µM 2.41286829140357 0.00761563882903323 no 67 0.00791376894495548 131 25236367 SGTC_287 k060-0039 29.6 µM 2.39315433336398 0.00803786073514337 no 68 0.00835210650057479 98 5861974 SGTC_667 1498-1044 59 µM 2.37068365940002 0.00854409869971063 no 69 0.00887761012834547 140 6739982 SGTC_3048 9093155 49.47 µM 2.35670249034556 0.00887301002172542 no 70 0.00921900609146905 82 25236002 SGTC_2182 6325192 200 µM 2.34989163869298 0.00903721900663192 no 71 0.00938943856207055 105 736248 SGTC_1901 st060216 58.6 µM 2.33393756647236 0.00943232712603567 no 72 0.00979949565914588 136 688792 SGTC_554 4483-2211 187 µM 2.3247667998176 0.0096662156649536 no 73 0.0100422165888877 134 747107 SGTC_3041 9091929 49.47 µM 2.3197360638276 0.00979665834209313 no 74 0.0101775798266581 144 25236887 SGTC_1783 st039459 87.517 µM 2.30581191635146 0.0101657484076263 no 75 0.0105605720461488 153 729761 SGTC_2184 6075246 200 µM 2.2952079381083 0.0104549111183445 no 76 0.0108606052445934 135 2267320 SGTC_1808 st050063 61.5 µM 2.29200634954814 0.0105436133681612 no 77 0.0109526383921805 121 4011993 SGTC_1384 3089-0840 101 µM 2.2717761521914 0.0111194114568936 no 78 0.0115500169723094 129 1069836 SGTC_1809 st050081 57.6 µM 2.27065614225827 0.0111520734559983 no 79 0.011583900978984 154 5036894 SGTC_1929 genistein trimethyl ether 50.5 µM 2.25663051774405 0.0115682090506737 no 80 0.0120155858966619 140 136420 SGTC_1452 4194-0072 190 µM 2.24154153142594 0.0120308867581138 no 81 0.0124955092290412 169 1343545 SGTC_2514 salinomycin 42.74 µM 2.24149991328896 0.0120321847792391 no 82 0.0124968555692435 214 23682228 A polyether potassium ionophore. SGTC_2769 toremifene 3.73 µM 2.22429768823866 0.0125792081260672 no 83 0.0130642110746375 163 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3214 9129694 49.47 µM 2.20194410485254 0.0133221101184889 no 84 0.0138346285042173 177 17158655 SGTC_1022 4477-0945 21.3 µM 2.19051672742732 0.0137163172488142 no 85 0.0142433915072635 179 4648966 SGTC_190 3970-0790 3.722 µM 2.18401056855571 0.0139452232694143 no 86 0.0144807357371422 134 2832352 SGTC_1779 st039427 55 µM 2.18009504893077 0.0140845643275682 no 87 0.0146252083509517 217 1124498 SGTC_2963 9082507 9 µM 2.16864873631063 0.0144988038760714 no 88 0.0150546810474414 159 16459611 SGTC_2994 9053520 71.4286 µM 2.15983567972815 0.0148248521786901 no 89 0.015392696233895 165 4647384 SGTC_640 3381-0960 37.1 µM 2.14917703362451 0.015227586835645 no 90 0.0158101845539457 158 1745025 SGTC_2522 biochanin a 4.94 µM 2.1390337539666 0.0156195401885452 no 91 0.0162164673991804 152 5280373 A possible chelator. SGTC_2770 toltrazuril 17.5 µM 2.1377109934571 0.015671286478019 no 92 0.0162701033544183 195 68591 Kills coccidiodes. SGTC_1054 3429-0080 167 µM 2.13644900844876 0.0157207922627925 no 93 0.0163214165222447 199 1162877 SGTC_2408 sulbentine 18.36 µM 2.13471051218446 0.0157892105335631 no 94 0.0163923318970141 215 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_422 cantharidin 155 µM 2.13305718820608 0.0158545136234473 no 95 0.0164600175881909 258 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_416 estradiol valerate 100 µM 2.12682108453945 0.0161029160403508 no 96 0.0167174758685796 172 13791 A steroid. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.11523636051134 0.0165732288121193 no 97 0.0172049036922875 428 16725076 SGTC_2009 4012297 12.05 µM 2.10548312559262 0.0169782552763641 no 98 0.0176246373359234 221 45595307 SGTC_2041 5107442 45.335 µM 2.10108789572923 0.0171635258767312 no 99 0.0178166256225212 227 793005 SGTC_1386 3228-0095 33.8 µM 2.09867744056174 0.0172658645218077 no 100 0.0179226723218779 166 870181 SGTC_3264 9137442 49.47 µM 2.09480314137477 0.0174314445235301 no 101 0.0180942478792768 141 17015726 SGTC_563 tetrahydrosecaminediol 614 µM 2.08913700364069 0.0176760447782603 no 102 0.0183476961090036 203 334274 A psychoactive constituent of the cannabis plant. SGTC_1329 1447-1697 50.6 µM 2.08617394132278 0.0178051187892495 no 103 0.0184814349016316 199 2840515 SGTC_1780 st038448 24.544 µM 2.08130474766087 0.0180189720098405 no 104 0.0187030104417417 207 728868 YDL195W SEC31 SGTC_2585 alliin 100 µM 2.07287778683819 0.0183942565195161 no 105 0.0190918273943207 225 87310 A garlic compound which reacts with lipids. SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.06637033940595 0.0186885947285336 no 106 0.0193967621803853 227 804 An inhibitor of viral and cellular DNA polymerases. SGTC_188 3229-0966 278.469 µM 2.0628426501011 0.0188498245410611 no 107 0.0195637901894279 244 5722370 SGTC_1842 st055362 61.2 µM 2.05566813917701 0.0191813821778475 no 108 0.0199072574861513 222 676032 SGTC_473 2-arachidonoylglycerol 10 µM 2.04442154935144 0.0197110958761906 no 109 0.0204559601225418 208 5282280 An endocannabinoid. SGTC_2002 4023503 131 µM 2.03632655529456 0.0201000114706533 no 110 0.0208587874887601 269 4736863 YCR052W RSC6 SGTC_1076 itraconazole 331 nM 2.03594152685623 0.0201186707710763 no 111 0.0208781136129763 210 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2871 9038510 12.99 µM 2.02834583163924 0.0204897887423644 no 112 0.0212624822062746 199 4945164 SGTC_1067 clotrimazole 1.36 µM 2.01539754111094 0.0211358007299912 no 113 0.0219315059380928 239 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.01480159052905 0.0211659438819865 no 114 0.0219627211684861 227 5282309 SGTC_2704 st078022 71.1 µM 2.0080311098541 0.0215109553542701 no 115 0.0223199929487409 198 54697681 SGTC_1813 st051246 8.6015 µM 1.98561786572979 0.0226871922053014 no 116 0.023537885581397 175 5291959 SGTC_293 4049-0273 38.5 µM 1.98492661801547 0.022724313754272 no 117 0.0235763182112461 183 1380311 SGTC_792 4534-1957 155 µM 1.97724520566755 0.0231402789795369 no 118 0.0240069600184529 220 1717904 SGTC_130 0136-0219 337.655 µM 1.9690205559989 0.0235927501530946 no 119 0.0244753653059231 232 234244 SGTC_1393 3470-5649 58.2 µM 1.96721088815126 0.0236932998463486 no 120 0.0245794516419629 165 4108395 SGTC_1072 oxiconazole 14.9 nM 1.96686099791844 0.0237127821400088 no 121 0.0245996190082081 271 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1106 tegaserod maleate 11.7 µM 1.9658304306606 0.0237702436023089 no 122 0.0246591006976661 255 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1101 ebselen 5.29 µM 1.96497540279161 0.0238180063061728 no 123 0.0247085422546565 234 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2947 9072639 7.68 µM 1.96490008843191 0.0238222173044374 no 124 0.0247129012522097 301 16488146 SGTC_3336 9143619 71.43 µM 1.96051787669745 0.0240683166849592 no 125 0.0249676453012997 231 45595730 SGTC_1748 st037455 53.6035 µM 1.95899979687145 0.0241540667238288 no 126 0.0250564052866719 264 580690 SGTC_1458 k015-0034 6.33 µM 1.94560469171894 0.0249218812649002 no 127 0.0258511215037238 211 3598957 SGTC_1012 4112-3522 18 µM 1.9402759925909 0.0252329643939279 no 128 0.0261730786931891 251 3112398 SGTC_1270 0831-1170 17.3 µM 1.93896321881854 0.0253101001346936 no 129 0.026252908513192 233 6764716 SGTC_2044 5102272 200 µM 1.93827831747559 0.0253504218094251 no 130 0.0262946381287666 180 592666 SGTC_814 3342-0569 96 µM 1.93816467864623 0.0253571171837991 no 131 0.0263015672668875 267 4346283 SGTC_1137 ixabepilone 100 µM 1.93089775724621 0.025788356365049 no 132 0.0267478488026368 288 154225 A novel microtubule stabilizer. SGTC_2811 7967822 32.47 µM 1.92453073177412 0.0261712218217184 no 133 0.0271440462260486 239 2232244 SGTC_1756 st041558 35.5 µM 1.92382984495976 0.0262136568543272 no 134 0.0271879575854072 240 3955792 SGTC_928 2764-0428 58.7 µM 1.9223752010588 0.02630191155247 no 135 0.0272792818441303 284 662578 SGTC_1792 st045773 43.6 µM 1.91737621989727 0.0266071003406051 no 136 0.0275950765364551 261 2919270 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.91632414668391 0.0266717050031147 no 137 0.0276619245951139 242 6708760 SGTC_622 1348-1566 26.3 µM 1.89762909485425 0.0278417349686536 no 138 0.0288724794664829 278 7340407 SGTC_1644 st010134 20.9 µM 1.87951691262153 0.0290157615236476 no 139 0.0300869732098753 212 3818134 SGTC_2388 9080168 200 µM 1.87207122039238 0.0295101797170521 no 140 0.03059837548643 191 15943073 SGTC_1881 5652484 16 µM 1.87087654943041 0.0295901571280369 no 141 0.030681097060996 273 2255129 SGTC_2471 5466956 24.79 µM 1.85469404285523 0.0306913314398664 no 142 0.0318199649680762 202 724419 SGTC_1225 1216-0074 20.6 µM 1.85001505754798 0.0310159751316719 no 143 0.0321556896904247 253 4241466 SGTC_2720 fluspirilene 36.88 µM 1.8401489224512 0.0317098379142589 no 144 0.0328731882343711 203 3396 An atypical antipsychotic. SGTC_1267 0828-0272 9.49 µM 1.83219038054407 0.0322788459475161 no 145 0.0334615307662277 280 745334 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.83151670101938 0.0323273961019802 no 146 0.033511728622853 262 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1320 1313-0481 95.3 µM 1.82473857978264 0.0328192371302668 no 147 0.0340202442028507 268 6813365 YLR208W SEC13 SGTC_968 1309-0633 340 µM 1.82263657861624 0.0329730120179888 no 148 0.0341792258562369 258 3761976 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.82063891839848 0.0331197035234585 no 149 0.0343308813852424 289 1377 SGTC_189 3970-0742 2.116 µM 1.81911124495176 0.0332322455621178 no 150 0.0344472299168473 217 2891807 SGTC_1591 genipin 88.4 µM 1.81507057326155 0.0335314365778855 no 151 0.0347565323554166 231 442424 A DNA cross-linking agent. SGTC_2761 levamisole 97.89 µM 1.81366372318206 0.0336361256008286 no 152 0.0348647566721211 265 26879 An alkaline phosphatase inhibitor. SGTC_1193 1488-0126 41.5 µM 1.81010002374966 0.033902518089456 no 153 0.0351401386553632 301 1384710 SGTC_2732 terfenadine 20 µM 1.80556089316796 0.0342443361092035 no 154 0.0354934779258846 209 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2945 9067681 61.76 µM 1.80469044597293 0.0343102075261973 no 155 0.0355615678533005 238 16456930 SGTC_1236 0330-0013 258 µM 1.80456096429942 0.0343200149919381 no 156 0.035571705580737 247 4617066 SGTC_1346 1488-2224 62.4 µM 1.80369820584739 0.0343854226446547 no 157 0.0356393154870507 263 3722427 SGTC_2325 6158266 200 µM 1.80016543303398 0.0346543193839067 no 158 0.0359172600932149 287 3623240 SGTC_2649 anisomycin 9.56 µM 1.78587296745809 0.035759871304212 no 159 0.0370599144145166 220 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1039 k821-0043 94 µM 1.78283589250074 0.0359984801473788 no 160 0.0373065105911683 294 15992768 SGTC_703 3875-0075 71.8 µM 1.78207708277424 0.0360582994709454 no 161 0.037368331213909 240 2850814 SGTC_2991 9074669 71.4286 µM 1.77781396585238 0.0363958893856325 no 162 0.0377172069903609 353 17333109 SGTC_799 1310-0557 151 µM 1.76887583801752 0.0371120854040102 no 163 0.0384572985940367 318 5354492 SGTC_3329 9141233 27.5565 µM 1.76822984284337 0.0371642910324356 no 164 0.0385112435375825 268 4909101 YNL103W MET4 SGTC_3342 9147791 14.508 µM 1.76290951127102 0.0375965358767262 no 165 0.0389578763139703 285 1838168 SGTC_3316 9136639 10.545 µM 1.75331839269425 0.0383861216496736 no 166 0.0397736850603873 277 4903665 SGTC_1281 0884-0031 11.8 µM 1.75100876881436 0.0385782666250355 no 167 0.0399721997871751 329 1548255 SGTC_597 k018-0003 82.8 µM 1.75004267640697 0.0386588710788542 no 168 0.0400554749953372 297 6786234 SGTC_2560 caryophyllene 100 µM 1.74998522184859 0.0386636690323591 no 169 0.0400604318995851 333 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_339 3091-4833 71.4 µM 1.74813756176799 0.0388182235135345 no 170 0.0402201050921243 255 3240077 SGTC_1922 5578187 25 µM 1.74569651799278 0.039023185000724 no 171 0.0404318502376191 322 1350412 SGTC_2894 9048625 32.47 µM 1.74123139314176 0.0394003773445574 no 172 0.0408215132653142 283 4092861 SGTC_2200 6600604 21.907 µM 1.7406203517338 0.039452225163244 no 173 0.0408750739218881 346 2904777 SGTC_2953 9074162 66.49 µM 1.74040577630566 0.0394704453860038 no 174 0.0408938959883703 265 16451992 SGTC_2132 5317594 122.667 µM 1.73999452511171 0.0395053850505117 no 175 0.040929989654776 260 794577 SGTC_1728 st035614 33.7865 µM 1.73856309539255 0.039627194720387 no 176 0.0410558213519295 390 15945546 SGTC_290 2043-6722 48.1 µM 1.73782055798794 0.039690502272579 no 177 0.0411212185455168 287 773758 YLR208W SEC13 SGTC_444 curcumin 90.4 µM 1.7306354341768 0.0403073519436456 no 178 0.0417584038048298 321 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2075 5212009 200 µM 1.72566690819688 0.0407384408958729 no 179 0.0422036773343657 253 780898 SGTC_941 3237-0776 460 µM 1.72513597049743 0.0407847275825273 no 180 0.0422514857227869 278 760008 SGTC_1628 st004252 77.7 µM 1.72069424535235 0.0411736272123352 no 181 0.0426531605912732 327 692968 SGTC_361 000s-0510 1.45 µM 1.7188640455825 0.0413347443870125 no 182 0.0428195651608084 346 660 SGTC_2364 9055074 200 µM 1.71380030143572 0.041783182956317 no 183 0.0432827040192533 290 6470630 SGTC_3053 9095903 49.47 µM 1.71367809552167 0.0417940538497971 no 184 0.043293930977695 265 17174018 SGTC_3259 9138485 49.47 µM 1.7033182775122 0.0427239764963615 no 185 0.044254260973001 372 17646153 SGTC_2419 paclitaxel 166.5 µM 1.70275069882121 0.0427754032034095 no 186 0.0443073663221605 414 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2436 5633522 8.09 µM 1.70092929848932 0.0429407731594264 no 187 0.0444781321065593 347 5724242 SGTC_3 0833-0587 95.581 µM 1.69892449834705 0.043123391330358 no 188 0.044666705202461 299 5382644 SGTC_3292 9120825 59.784 µM 1.6833030067663 0.0445679413775145 no 189 0.0461582243266423 317 24824900 SGTC_1888 azatryptophan 97.5 µM 1.68123626766128 0.0447619431549921 no 190 0.0463585157772686 276 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_160 3453-0671 289.699 µM 1.67945930174405 0.0449292875148411 no 191 0.0465312821121255 365 5322268 SGTC_2105 5350118 200 µM 1.67606383552835 0.0452504532706241 no 192 0.0468628447527103 319 2133313 SGTC_835 0312-0010 67.2 µM 1.67295383321376 0.045546236105339 no 193 0.0471681924214815 296 1626196 SGTC_680 0417-1641 114 µM 1.66845544454725 0.0459768124995362 no 194 0.0476126748482833 309 2835990 SGTC_1641 st009299 47.1 µM 1.66830992762731 0.0459907954946066 no 195 0.0476271090923379 252 4046054 SGTC_493 zm226600 134 µM 1.66453366177446 0.0463548602478957 no 196 0.0480029149426292 354 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3055 9094636 49.47 µM 1.66201930657057 0.0465985464589907 no 197 0.0482544517349102 303 25236176 SGTC_2511 berberine 10.47 µM 1.66154052734143 0.0466450650792213 no 198 0.0483024682410206 308 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_847 0342-0274 5.54 µM 1.65799073271862 0.046991129697958 no 199 0.048659668453162 335 18097 SGTC_2892 9047358 58.44 µM 1.65622331469146 0.0471641989770777 no 200 0.0488383017116591 261 6466771 SGTC_1219 1469-0211 33.1 µM 1.65548355885362 0.0472367889448807 no 201 0.0489132243720992 300 6822282 SGTC_2272 7805186 180 µM 1.65542275945536 0.0472427589832127 no 202 0.0489193862327028 308 2956062 YPR165W RHO1 SGTC_2123 5259487 200 µM 1.65338530641671 0.0474431713110444 no 203 0.0491262356780515 343 2173474 SGTC_1178 0988-0033 191 µM 1.64772807046582 0.048003213576988 no 204 0.049704242562466 373 5392207 SGTC_442 cape 100 µM 1.64044088523397 0.0487323977282851 no 205 0.0504567651302646 304 5281787 SGTC_820 1582-0060 59.9 µM 1.63460238047186 0.0493229869332798 no 206 0.0510662141576312 389 3848840 SGTC_180 1486-1293 102.781 µM 1.62508444303085 0.050298003317665 no 207 0.0520722836181837 354 4140536 SGTC_83 0170-0301 39.027 µM 1.62122026292338 0.0506982077197532 no 208 0.0524852042952154 206 3089716 SGTC_335 4077-0256 27.6 µM 1.61756949583384 0.0510786352299856 no 209 0.0528777037178128 399 3121989 SGTC_2208 7283366 200 µM 1.61684931422118 0.0511539492310181 no 210 0.0529554057795695 345 898663 SGTC_2768 sulfasalazine 50.2 µM 1.61658725140929 0.0511813767342259 no 211 0.0529837028047964 338 5384001 An antioxidant and salicylic acid derivative. SGTC_627 1391-0720 175 µM 1.61563950821075 0.0512806652627395 no 212 0.0530861383605883 348 997839 SGTC_650 1328-0195 38 µM 1.61507581599087 0.0513397920495282 no 213 0.0531471387161447 383 2780821 SGTC_1305 1181-0477 144 µM 1.61457536566347 0.0513923307024294 no 214 0.0532013418640971 343 6252086 SGTC_1104 tacrolimus 29.8 µM 1.61239629876434 0.0516215938116498 no 215 0.0534378648877675 379 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3000 9075062 71.4286 µM 1.6012661221862 0.0528053278961741 no 216 0.0546589945619965 350 17057871 SGTC_1814 st052110 31.539 µM 1.59417135571342 0.0535710521532489 no 217 0.0554488301549552 340 674163 SGTC_2397 5161689 200 µM 1.59145878969084 0.0538661283471096 no 218 0.0557531813701821 401 2259942 SGTC_1332 1480-0653 17.5 µM 1.58694337017498 0.0543601736973577 no 219 0.0562627355081927 378 5749438 SGTC_2276 7947513 42.08 µM 1.58497973132118 0.0545761365326162 no 220 0.0564854697408738 348 2105100 SGTC_454 lyso-paf C-16 6.67 µM 1.58277090143298 0.0548198759410904 no 221 0.0567368456479437 359 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2188 6126565 140.678 µM 1.58039063998154 0.055083494778209 no 222 0.0570087168869674 296 874518 SGTC_1163 k060-0048 49.9 µM 1.57938866068747 0.0551947651464569 no 223 0.0571234683378356 421 6809982 SGTC_1322 1348-1070 12 µM 1.57701866431808 0.0554586612291683 no 224 0.0573956152714996 317 6758089 SGTC_2702 st077768 96.8 µM 1.57334667912657 0.0558694983293205 no 225 0.0578192831289674 361 6484119 SGTC_292 k038-0015 474 µM 1.57086332107947 0.0561487052427262 no 226 0.0581071999877718 351 46368540 SGTC_3192 9110362 49.47 µM 1.57029449858722 0.0562128132517825 no 227 0.0581733067372411 379 16649480 SGTC_2481 5478948 45.16 µM 1.56567399476567 0.0567356985201662 no 228 0.0587124786651506 393 77792 SGTC_3143 9086658 49.47 µM 1.56416287463796 0.0569075353185547 no 229 0.0588896616856116 457 25236626 SGTC_2185 6113692 200 µM 1.56326818189073 0.0570094681663115 no 230 0.0589947644677085 354 874150 SGTC_1725 st036284 20.55 µM 1.56308308745023 0.0570305740149103 no 231 0.0590165265393263 443 707914 SGTC_1575 cyproterone acetate 48 µM 1.55362785240001 0.0581169371276102 no 232 0.0601366058145662 384 9880 An androgen receptor antagonist and liver toxin. SGTC_2677 mitomycin C 100 µM 1.54715566830037 0.0588698892441714 no 233 0.0609128564993492 316 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_512 prima-1 270 µM 1.5452461873872 0.0590934880528231 no 234 0.0611433631544185 398 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3323 9138564 53.9225 µM 1.54179155411076 0.0594997153027915 no 235 0.0615621275624479 448 43912313 YNL103W MET4 SGTC_1643 st009866 20.2 µM 1.54165487530793 0.0595158321414363 no 236 0.0615787414658766 342 3156273 YOR207C RET1 SGTC_2309 7664088 163.95 µM 1.53730940423931 0.0600300256635265 no 237 0.0621087798164198 452 704922 SGTC_2606 farnesol 9.78 µM 1.52659530348979 0.0613126732651468 no 238 0.063430837802093 418 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3266 9136860 49.47 µM 1.52377339902288 0.0616540374931556 no 239 0.0637826633791375 411 4871271 YPR165W RHO1 SGTC_3147 9097027 49.47 µM 1.52068328317238 0.062029547423754 no 240 0.0641696678675378 408 25236841 SGTC_2905 7799065 20.05 µM 1.51636331388536 0.0625574971504041 no 241 0.0647137550793817 364 1296806 SGTC_1044 1222-0021 1.78 µM 1.51593846929302 0.0626096066432954 no 242 0.0647674558928885 427 4306703 SGTC_2030 5175110 200 µM 1.51317481040708 0.062949410732035 no 243 0.0651176304395739 393 2831986 SGTC_1318 1280-3875 124 µM 1.51125347476435 0.0631864928227573 no 244 0.0653619413723336 444 373245 SGTC_3263 9137018 49.47 µM 1.5110620648355 0.0632101497725187 no 245 0.0653863193438706 417 43844957 SGTC_3293 9120939 62.045 µM 1.50900605510299 0.063464693522021 no 246 0.0656486177004475 403 934087 SGTC_2630 antimycin a 100 µM 1.50564611957858 0.0638823857427642 no 247 0.0660790212095597 464 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_111 0083-0039 52.457 µM 1.5033704161805 0.0641665033399059 no 248 0.0663717754961776 246 759313 SGTC_857 0438-0306 1.35 µM 1.50203695614428 0.0643334393275112 no 249 0.066543782423285 427 4686136 SGTC_3102 9121669 49.47 µM 1.50028400750158 0.0645534043555145 no 250 0.066770425134676 353 41905072 SGTC_1802 st050112 57.9 µM 1.49887437573776 0.0647307124319057 no 251 0.0669531125324073 415 4662563 SGTC_402 epigallocatechin gallate 10 µM 1.49687008517686 0.0649834694988743 no 252 0.0672135327395533 443 65064 An antioxidant. SGTC_676 falcarinol 140 µM 1.49151332889378 0.0656627594190072 no 253 0.0679133872083027 456 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2236 dapsone 200 µM 1.48920204907225 0.0659575473235297 no 254 0.0682170856993404 434 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1241 0364-0022 50.8 µM 1.48510839757914 0.0664821799053206 no 255 0.0687575559634401 452 4563895 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.48263647597204 0.0668005363155753 no 256 0.069085510232222 471 442882 SGTC_3313 9133968 57.047 µM 1.48212469032562 0.0668665958447642 no 257 0.0691535601323351 447 1494643 SGTC_1710 st031758 61.5 µM 1.48055475940067 0.0670695524474382 no 258 0.0693626292282414 386 5394341 SGTC_931 2812-0076 566 µM 1.47874097212049 0.067304626960158 no 259 0.0696047786751334 456 3450959 SGTC_1428 4049-0204 61.7 µM 1.47545812907062 0.0677317163407286 no 260 0.0700447086497882 446 X1428 SGTC_553 k007-0256 45.7 µM 1.47237609942183 0.0681345828902613 no 261 0.070459671806305 459 6287000 SGTC_1911 st060208 74.3 µM 1.47161656683226 0.0682341484814602 no 262 0.0705622246406524 474 688783 SGTC_2069 5228469 200 µM 1.46973904883171 0.0684807503714092 no 263 0.0708162212712271 405 2835210 SGTC_3222 9128301 49.47 µM 1.46747123236998 0.0687795319917566 no 264 0.0711239547013467 428 4911358 SGTC_1221 2958-7315 257 µM 1.46485262889584 0.0691257785344347 no 265 0.0714805647276251 444 4562705 SGTC_1272 0839-0021 27 µM 1.46455634771787 0.0691650389383661 no 266 0.0715209995268422 455 5027250 SGTC_1453 4237-0541 195 µM 1.4638257295551 0.0692619270300692 no 267 0.0716207852149741 417 739892 SGTC_224 benfluorex 43.875 µM 1.46379802389768 0.0692656031649243 no 268 0.071624571273432 308 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1006 4099-6547 255 µM 1.45129002040013 0.0709406350471971 no 269 0.0733495595039748 452 3146833 SGTC_1854 st056233 32.9 µM 1.45016285626188 0.0710930965310569 no 270 0.0735065551497442 431 5393174 SGTC_1563 conessine 56.1 µM 1.44808657692289 0.0713745948672569 no 271 0.0737964195516049 537 441082 An anti-amoebic, histamine inhibitor. SGTC_2453 5731132 22.18 µM 1.44766939208292 0.0714312591408272 no 272 0.0738547669942923 476 1362040 SGTC_916 4466-0038 42 nM 1.44638719997057 0.0716056294508017 no 273 0.0740343149934327 588 5722064 YGL116W CDC20 SGTC_1909 st060837 51.5 µM 1.44427713005388 0.0718932967897492 no 274 0.0743305181317387 473 678937 SGTC_2314 7727897 200 µM 1.44318382286309 0.072042696278072 no 275 0.0744843476827814 433 900724 SGTC_2683 piperine 63.03 µM 1.44086323967627 0.0723605905952606 no 276 0.0748116615611917 416 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1555 citronellol 128 µM 1.43743482781971 0.0728322107089713 no 277 0.0752972393204107 405 8842 A terpine precursor. SGTC_2321 7390090 138.78 µM 1.43263794820489 0.0734960255088237 no 278 0.0759806655160066 409 649046 SGTC_1129 3453-1384 223 µM 1.43223139458417 0.0735524983037818 no 279 0.0760388048685392 509 1084452 SGTC_1422 4031-0024 15.5 µM 1.43208696457339 0.0735725685046504 no 280 0.0760594672875936 443 782427 SGTC_2337 9009472 200 µM 1.43138129793178 0.0736706891647946 no 281 0.0761604827021172 506 5742383 SGTC_2468 5987765 72.9 µM 1.43026647145989 0.073825905992118 no 282 0.0763202769549142 457 26772094 SGTC_943 3253-1379 105 µM 1.42846592421077 0.0740771230836691 no 283 0.0765788979547509 454 668464 SGTC_2271 7849410 118.62 µM 1.4269974391388 0.0742824930556047 no 284 0.0767903163884346 446 972430 SGTC_589 1227-0070 34.1 µM 1.42347177161628 0.0747773381142984 no 285 0.0772997197828906 458 2841384 SGTC_358 0075-0058 9.45 µM 1.42099840535809 0.0751259858578287 no 286 0.0776586115158026 583 1069125 SGTC_2459 5811157 9.22 µM 1.41995953531396 0.0752727949548286 no 287 0.0778097309025935 442 2870684 YBR192W RIM2 SGTC_186 3455-3465 67.277 µM 1.4151105334154 0.0759609313518018 no 288 0.0785180451429423 349 755278 SGTC_3139 9095020 49.47 µM 1.41467854881056 0.0760224672014062 no 289 0.0785813833126261 333 25236292 SGTC_2618 avocadyne 43.43 µM 1.41450833384726 0.0760467246030905 no 290 0.0786063510951362 432 3015189 SGTC_1976 st070609 63.5 µM 1.41373468658037 0.076157051642908 no 291 0.0787199084128207 486 682556 SGTC_3015 9080845 49.47 µM 1.41082253940525 0.0765734350390254 no 292 0.0791484733735322 478 5296973 SGTC_1899 st063254 59.6 µM 1.40832805758068 0.0769314749146904 no 293 0.0795169756033522 412 3093813 SGTC_894 0960-0238 55.9 µM 1.40455397781149 0.0774755962327966 no 294 0.0800769750196229 468 6741907 YDL195W SEC31 SGTC_377 3970-0964 33.1 µM 1.40234252979052 0.0777957830471872 no 295 0.0804064930117877 580 16481235 SGTC_1414 3917-0015 5.4 µM 1.4012865870646 0.0779490226449137 no 296 0.0805641952535939 437 6618702 SGTC_883 0850-0245 24.6 µM 1.40121769016485 0.0779590289945554 no 297 0.0805744929360902 514 6823229 YPR165W RHO1 SGTC_1333 1482-0047 286 µM 1.39601343566458 0.0787176978841273 no 298 0.0813552246249001 518 3811116 SGTC_962 1254-0300 21.5 µM 1.39552769449496 0.0787887930264068 no 299 0.0814283846853785 477 7340576 SGTC_2616 abietic acid 100 µM 1.39527741579912 0.0788254438670142 no 300 0.0814660998555045 511 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2153 5569715 200 µM 1.39061912873863 0.079509963714119 no 301 0.0821704763090036 462 2054701 SGTC_876 0720-0963 56.8 µM 1.38982289388862 0.0796274165967154 no 302 0.0822913321503291 527 765861 SGTC_1289 0976-0073 69.1 µM 1.38962951361168 0.0796559619915021 no 303 0.0823207044077785 499 3391136 SGTC_1787 fluconazole 80 µM 1.38857085251806 0.0798123710880089 no 304 0.0824816428781589 556 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_127 0180-0333 59.125 µM 1.38659779668071 0.0801044947432679 no 305 0.082782220278998 594 771601 SGTC_27 0485-0001 32.618 µM 1.38659334157564 0.0801051552637018 no 306 0.0827828999057512 358 2054479 SGTC_1156 4092-0367 4.88 µM 1.3864832620257 0.0801214771275042 no 307 0.082799693886304 507 1357585 SGTC_393 acivicin 6.25 µM 1.38489140765735 0.0803577878302296 no 308 0.083042837374149 448 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2823 7987624 58.44 µM 1.38413952340531 0.0804695879682997 no 309 0.0831578684530524 527 2239440 SGTC_2561 acetosyringone 100 µM 1.38200090957323 0.0807882279335117 no 310 0.0834857109120328 560 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_996 3970-0799 1.8 µM 1.37781055731356 0.0814153246815813 no 311 0.0841308928120681 656 6615648 YGL040C HEM2 SGTC_659 k018-0002 107 µM 1.37592155133188 0.0816992168427509 no 312 0.0844229610797255 502 6797879 YHR007C ERG11 SGTC_2007 4011539 71.82 µM 1.37585946694963 0.0817085599398251 no 313 0.0844325731399557 511 45595301 SGTC_1751 st044839 27.194 µM 1.37559307894786 0.0817486578918703 no 314 0.0844738253207716 457 5291326 SGTC_7 0192-1582 4.227 µM 1.36694369319197 0.0830586771936227 no 315 0.0858214775988689 612 252616 SGTC_2440 5628896 157.78 µM 1.36574990538572 0.0832407190209522 no 316 0.0860087372742072 469 5522048 SGTC_3091 9116372 49.47 µM 1.3647118285035 0.0833992600396945 no 317 0.0861718202253674 462 17169793 SGTC_1793 st048256 72.231 µM 1.36186713793524 0.083834880485028 no 318 0.0866199093833852 470 672022 SGTC_1382 3002-2117 298 µM 1.35899968017668 0.0842757146875983 no 319 0.0870733450255396 521 1497314 SGTC_1399 3562-5772 25 µM 1.35816453866962 0.0844044333501659 no 320 0.0872057400412861 410 23847490 SGTC_862 0452-0056 10.2 µM 1.35715553502217 0.0845601457387989 no 321 0.0873658978686404 488 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_345 1362-0200 395 µM 1.35592485924347 0.084750358793311 no 322 0.0875615385224701 477 1419823 SGTC_1172 0370-0043 85 µM 1.35427527971629 0.0850058205687992 no 323 0.0878242848847512 481 376585 SGTC_1345 1488-0192 31.4 µM 1.35088206195397 0.0855331245541178 no 324 0.0883666076201161 520 658348 SGTC_2907 7721985 69.9 µM 1.34806600236973 0.0859725953523594 no 325 0.0888185774965676 498 3267881 SGTC_285 1486-1325 46 µM 1.34596582080642 0.0863014454681684 no 326 0.0891567698281946 551 22310230 SGTC_2885 9057732 51.95 µM 1.34476391987274 0.0864900639633379 no 327 0.0893507426183263 498 6471414 SGTC_1785 bathophenanthroline 24 µM 1.3397027670598 0.0872877105494652 no 328 0.0901709988041115 534 72812 An iron chelator. SGTC_3014 9081533 49.47 µM 1.33965586529505 0.0872951279469159 no 329 0.0901786261995915 531 21367265 SGTC_257 daunorubicin 18.5 µM 1.33596499848728 0.0878803059806624 no 330 0.0907803569915897 463 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_77 0828-0286 12.516 µM 1.33528416420027 0.0879885694869511 no 331 0.0908916797716124 539 745345 SGTC_1876 myriocin 605 nM 1.33456585679665 0.0881028995986751 no 332 0.0910092395207862 509 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1008 4106-0037 6 µM 1.33389410064086 0.0882099205204581 no 333 0.0911192826172035 498 2905394 SGTC_1482 3346-2049 8.48 µM 1.33304137663442 0.0883459118960465 no 334 0.0912591128863937 498 3826804 SGTC_3211 9128781 49.47 µM 1.33301849492328 0.0883495631944424 no 335 0.0912628672358135 531 17194361 SGTC_945 3381-0768 11.3 µM 1.3323473991208 0.0884567018432559 no 336 0.0913730291758312 542 1126236 YIL048W NEO1 SGTC_1479 0549-0158 134 µM 1.32870131738794 0.0890404811797667 no 337 0.091973265068042 580 5440202 SGTC_472 calcifediol 10 µM 1.32865791073085 0.0890474483126349 no 338 0.0919804284307799 438 5283731 A vitamin D metabolite. SGTC_3169 9102970 49.47 µM 1.32624054253891 0.089436097028177 no 339 0.0923800170760341 501 17027839 SGTC_2516 gossypol 71.55 µM 1.32310348406064 0.0899423320609336 no 340 0.0929004831229989 564 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1889 st059080 5.18 µM 1.32286648687728 0.0899806632326126 no 341 0.0929398909751313 568 176925 Isolated from Daphnopsis sellowiana. SGTC_101 0490-5701 117.494 µM 1.32209895830084 0.0901048841816574 no 342 0.0930676003177857 476 4661669 SGTC_1859 st055998 20 µM 1.32115072804965 0.0902585267359418 no 343 0.09322555572107 543 676301 SGTC_2402 5553605 200 µM 1.32014648004508 0.0904214579718894 no 344 0.0933930584120411 544 6758546 SGTC_1788 fluconazole 20 µM 1.31715234072439 0.0909085293380382 no 345 0.0938937827400828 521 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2858 9025781 8.96 µM 1.31702623511549 0.0909290861921308 no 346 0.0939149153870184 664 4894980 YPL153C RAD53 SGTC_2629 bisabolol 100 µM 1.31534396877776 0.0912036474155777 no 347 0.0941971636688776 564 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2399 5884133 200 µM 1.3146799230082 0.0913121948058933 no 348 0.0943087484140323 532 722445 SGTC_1884 5633444 25 µM 1.3117812300177 0.0917871476492765 no 349 0.0947969799090336 568 5724239 SGTC_1840 st055363 71 µM 1.31070303866866 0.091964276190071 no 350 0.0949790558346251 466 676033 SGTC_763 3453-1109 128 µM 1.29788865758404 0.0940888771681957 no 351 0.0971627990967978 552 1560353 SGTC_1853 st056710 91.2 µM 1.29786174499905 0.0940933770152832 no 352 0.0971674238151332 569 269167 SGTC_588 3970-1144 52.9 µM 1.29551237292808 0.094486809703649 no 353 0.0975717679468884 582 1888707 SGTC_3018 9082602 49.47 µM 1.29537943163962 0.0945091086425984 no 354 0.0975946849473889 568 17332089 SGTC_2536 dehydroabietamide 32.04 µM 1.29400813950083 0.0947393491171941 no 355 0.09783130465944 585 3983547 SGTC_2843 9000894 45.46 µM 1.29363661043761 0.0948018001001797 no 356 0.0978954852216076 400 2242070 SGTC_2594 a-mangostin 100 µM 1.29306183006259 0.0948984757188066 no 357 0.0979948376473308 589 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3064 1327-0027 10 µM 1.29216702653042 0.0950491223989667 no 358 0.0981496540066769 382 16000455 YPR107C YTH1 SGTC_2627 acetyl isogambogic acid 100 µM 1.29046047761419 0.0953369205079419 no 359 0.0984454128421568 524 6857789 A caspase activator and apoptosis inducer. SGTC_369 0957-0393 4.5 µM 1.29032982982546 0.0953589797959867 no 360 0.0984680820315618 514 6997992 SGTC_132 0417-1715 25.805 µM 1.28805239955981 0.0957441174386771 no 361 0.0988638617360292 584 6769098 SGTC_526 4469-0568 170 µM 1.2870151290781 0.0959199096977182 no 362 0.0990445074811839 543 2901964 SGTC_511 blebbistatin 171 µM 1.28561890316253 0.0961569108775412 no 363 0.0992880481357652 541 3476986 A myosin inhibitor. SGTC_706 4262-0057 46.9 µM 1.28292221293896 0.0966158764357151 no 364 0.0997596648866629 554 883298 SGTC_133 0724-0033 378.92 µM 1.28280999921891 0.0966350095620622 no 365 0.09977932504192 525 280309 SGTC_1600 coumarin 106 71.1 µM 1.2819065880342 0.0967891481088061 no 366 0.0999377083183836 591 100336 A hepatotoxic, DNA x-linker. SGTC_1421 4029-0249 71.4 µM 1.27776932085023 0.0974973489228647 no 367 0.100665387360931 598 2894095 SGTC_1181 1222-0449 220 µM 1.27389314416462 0.0981642988147713 no 368 0.101350644223178 562 658318 SGTC_1973 st070275 50.2 µM 1.27278118828423 0.0983562417415761 no 369 0.101547849170064 519 17118334 SGTC_1166 k206-0078 225 µM 1.27251670617326 0.098401936389564 no 370 0.10159479608119 607 5404595 SGTC_531 3788-1495 174 µM 1.2647930969801 0.0997432099633638 no 371 0.1029727532899 563 2896655 SGTC_1946 st076057 65.1 µM 1.26148039133214 0.100322565713556 no 372 0.103567910192508 434 953009 SGTC_353 1988-1175 58.3 µM 1.25514408538795 0.101437550018391 no 373 0.104713229578736 543 2788357 SGTC_3032 9089427 49.47 µM 1.2535346115049 0.101722197360189 no 374 0.105005605551501 535 17173707 SGTC_1379 2144-0755 36.5 µM 1.25190097791368 0.102011711759991 no 375 0.105302974198087 626 5392327 SGTC_1424 4048-1941 275 µM 1.25042066352736 0.102274572169522 no 376 0.10557296005779 633 X1424 SGTC_908 3448-7491 47.7 µM 1.25012747968776 0.102326691414381 no 377 0.105626491473597 675 1203031 SGTC_2442 5158906 48.48 µM 1.24868479718897 0.102583438251057 no 378 0.105890191758053 592 1893835 SGTC_1226 3909-7979 35.4 µM 1.2457053537802 0.103115156152274 no 379 0.106436293708409 641 6615510 SGTC_1435 4092-0789 56.7 µM 1.24514047869862 0.103216190290429 no 380 0.106540058525696 589 2248285 SGTC_2328 6201408 200 µM 1.24372810936249 0.103469122640966 no 381 0.106799823456472 572 2890418 SGTC_2480 5767542 37.17 µM 1.24102254683792 0.103954900550253 no 382 0.107298709914888 588 2867358 SGTC_5 0352-0601 109.883 µM 1.23592288191723 0.104875027012579 no 383 0.108243615325447 535 762456 SGTC_786 4544-0069 423 µM 1.23181333163017 0.105620787668433 no 384 0.109009411056292 636 748821 YLR208W SEC13 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.23072849405458 0.10581829146855 no 385 0.109212213640959 633 5106787 A p450 inhibitor. SGTC_2058 5236698 133 µM 1.23005292038306 0.105941420140726 no 386 0.109338644178123 580 766665 SGTC_112 phenothiazine 287.218 µM 1.22938651213719 0.106062979747965 no 387 0.109463462424541 609 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1304 1165-0502 251 µM 1.22758161377885 0.106392717484941 no 388 0.109802033671088 650 767425 SGTC_1623 st003709 20.3 µM 1.22538375694804 0.106795243703008 no 389 0.110215331999189 673 16192618 SGTC_3232 9132874 49.47 µM 1.22328862973583 0.107179977490886 no 390 0.110610350085992 575 3784940 SGTC_1603 st002045 67.8 µM 1.22291536931816 0.107248625053888 no 391 0.110680831466297 606 5887985 SGTC_432 NS 1619 61.3 µM 1.21969537372852 0.107842141772663 no 392 0.111290188003137 551 4552 A K+/calcium channel activator. SGTC_2100 5377183 190 µM 1.21950324251373 0.107877630465484 no 393 0.111326622964123 660 2844202 SGTC_607 4491-0986 66.8 µM 1.2193505657226 0.107905837500711 no 394 0.111355582040984 634 698981 YDR232W HEM1 SGTC_2458 5808907 16.39 µM 1.21921695604449 0.107930526244667 no 395 0.11138092897361 648 2731747 SGTC_2380 9035439 200 µM 1.21654674941982 0.108424787244507 no 396 0.111888356879097 652 6462575 SGTC_225 nsc-122657 1.016 µM 1.21637244272539 0.108457108321809 no 397 0.111921538324698 464 275685 SGTC_2023 5144124 124 µM 1.21531469238097 0.10865339192039 no 398 0.112123045162219 601 2830192 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.21428373625088 0.10884494913392 no 399 0.112319697002029 405 4000243 SGTC_827 3253-0474 693 µM 1.2132267205452 0.109041600329259 no 400 0.112521575385909 648 5402065 SGTC_1005 4092-0690 4.4 µM 1.21245342238827 0.109185629296131 no 401 0.112669430915747 583 1529343 SGTC_3298 9116858 71.43 µM 1.2107350863771 0.109506163478972 no 402 0.11299847537361 639 2506942 SGTC_3339 9145883 14.936 µM 1.20845275010371 0.109932948966064 no 403 0.113436579985775 574 2030670 SGTC_2374 9071832 200 µM 1.20691183499865 0.110221766557003 no 404 0.113733049678157 586 17381698 SGTC_1989 st071868 50.2 µM 1.20450739509951 0.110673523246865 no 405 0.114196762760262 619 16414057 SGTC_1360 1598-0022 39.8 µM 1.20386345258419 0.110794734945182 no 406 0.114321179864817 709 761525 SGTC_1073 triclabendazole 3.09 µM 1.20330000441908 0.11090087289365 no 407 0.114430123683672 681 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2983 9022671 12.99 µM 1.20238378626313 0.111073618372314 no 408 0.114607434047972 588 6405161 SGTC_2103 5378138 10 µM 1.19630607329532 0.11222440173539 no 409 0.115788569803074 687 244142 SGTC_2978 9011784 42.97 µM 1.19437959571104 0.112590942615576 no 410 0.116164757350602 731 2994934 SGTC_457 grayanotoxin iii 135 µM 1.19312135852139 0.112830802002559 no 411 0.116410923905322 688 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_123 0083-0120 66.675 µM 1.1904756939867 0.113336337934006 no 412 0.116929738861479 647 16001701 SGTC_2292 7671323 168.05 µM 1.18995612303884 0.113435807515688 no 413 0.117031818970518 623 937504 SGTC_1344 1488-0097 29.1 µM 1.18928668956485 0.113564059384427 no 414 0.117163435645818 620 747966 SGTC_1383 3049-0032 20.7 µM 1.18892301319945 0.113633776805928 no 415 0.117234981650246 635 712864 SGTC_1311 1190-0148 100 µM 1.18666112907295 0.114068069180837 no 416 0.117680656647861 742 1961333 SGTC_1743 st037606 46.3785 µM 1.18384150558649 0.11461110407755 no 417 0.118237904377403 619 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1240 0356-0016 42.1 µM 1.18064274525655 0.115229381984084 no 418 0.118872337596284 643 4305613 SGTC_551 k048-0028 34.9 µM 1.18001195891835 0.115351583970308 no 419 0.118997729284173 693 6836383 SGTC_2723 salbutamol 83.58 µM 1.17764723652985 0.115810520507288 no 420 0.11946863498249 529 9884233 β2-adrenoceptor agonist SGTC_2640 pentamidine 10.38 µM 1.17161606573558 0.116986894508388 no 421 0.120675617476037 704 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_753 1322-0200 289 µM 1.16905713028192 0.117488562438114 no 422 0.121190307232199 648 5403907 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.16898808211585 0.117502120096308 no 423 0.121204216548596 695 165506 SGTC_110 0850-0284 111.64 µM 1.1669025446654 0.117912138999721 no 424 0.121624864084544 509 3906265 SGTC_2724 maprotiline 69.64 µM 1.16463959876497 0.118358180513022 no 425 0.122082453901562 656 4011 A tricyclic antidepressant. SGTC_686 1319-0111 510 µM 1.1624299978865 0.11879485704183 no 426 0.122530422037854 703 4562600 SGTC_2370 9071495 200 µM 1.16045586339527 0.11918596060265 no 427 0.122931626842575 614 21791103 SGTC_3072 9116419 49.47 µM 1.15708810863059 0.119855255876775 no 428 0.123618182248897 570 17170162 SGTC_1587 estradiol valerate 56.1 µM 1.15642434249941 0.119987482326839 no 429 0.123753814727652 677 13791 A steroid. SGTC_1494 4358-1428 177 µM 1.15288422806361 0.12069443226186 no 430 0.124478953258508 684 1564571 SGTC_899 1083-0020 478 µM 1.15261205008214 0.120748906498912 no 431 0.12453482750279 679 767123 SGTC_3140 9094243 49.47 µM 1.15249973362555 0.120771390779237 no 432 0.124557889573729 674 19291112 SGTC_2517 totarol 10 µM 1.14998529227671 0.121275520545725 no 433 0.125074964516421 589 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3209 9113616 49.47 µM 1.14930370969276 0.12141242816727 no 434 0.125215384477887 708 16649353 SGTC_2583 asiatic acid 100 µM 1.14827457743852 0.12161935297563 no 435 0.125427615304526 638 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_671 0560-0003 407 µM 1.14794085680131 0.121686506458332 no 436 0.12549649008159 632 3238678 SGTC_2227 7312221 64.1025 µM 1.14763478166486 0.121748119833981 no 437 0.12555968245657 646 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_850 0388-0143 75.9 µM 1.14714430120297 0.121846899975009 no 438 0.125660993511432 644 67273 SGTC_2180 6301957 200 µM 1.14258687618403 0.122767433540103 no 439 0.126605078490027 668 845462 SGTC_2242 6630449 61.2675 µM 1.14027433999187 0.123236393005097 no 440 0.127086012341474 585 691249 YDR170C SEC7 SGTC_2546 rhodinyl acetate 100 µM 1.1390595821161 0.123483236154155 no 441 0.127339151950488 697 6708682 SGTC_2045 5106652 78.05 µM 1.13784974506105 0.123729423385517 no 442 0.127591614504963 661 673349 SGTC_1282 0886-0010 32.4 µM 1.13619238514038 0.124067233625884 no 443 0.127938028388417 768 2836211 YNL267W PIK1 SGTC_2157 5649910 96.377 µM 1.13523454405718 0.124262758915707 no 444 0.128138529706624 683 2858091 SGTC_2240 6690706 185.951 µM 1.13458285540387 0.124395912073935 no 445 0.128275069966572 576 805876 SGTC_3063 1327-0034 4 µM 1.1343246478919 0.124448696672824 no 446 0.128329196925692 650 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1650 st011916 45.8 µM 1.13422181712428 0.124469722422704 no 447 0.128350757323304 662 242528 SGTC_185 k048-0037 25.491 µM 1.12992331739761 0.125350856994783 no 448 0.129254268856382 707 6827589 SGTC_1981 st071826 47 µM 1.12940842035391 0.125456695267084 no 449 0.129362791185239 638 11838600 SGTC_1647 st011722 22.4 µM 1.12901304787355 0.125538007312732 no 450 0.129446164753882 645 2854783 SGTC_1111 tnp00062 510.699 nM 1.12843721536176 0.125656498425308 no 451 0.12956765914517 689 676306 SGTC_2287 7945887 168.79 µM 1.12816036237376 0.125713495221221 no 452 0.129626100222717 719 1245853 SGTC_2352 9027995 87.8 µM 1.12724759851848 0.125901537191443 no 453 0.129818905459319 625 2997347 SGTC_2373 9071805 200 µM 1.12469418595559 0.126428617050947 no 454 0.130359323137074 688 10149009 SGTC_3198 9112019 49.47 µM 1.12424448857723 0.126521603353793 no 455 0.130454660394947 659 45595555 SGTC_2846 9008642 19.48 µM 1.11806762624603 0.127803648433911 no 456 0.131769055878946 632 2992898 SGTC_3347 9188721 44.724 µM 1.1175600944577 0.127909389687255 no 457 0.131877460086392 655 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1928 4'-methoxychalcone 40.3 µM 1.11724697072057 0.127974657483751 no 458 0.131944371166758 710 641818 SGTC_1526 st051518 75 µM 1.11714592848315 0.12799572375668 no 459 0.131965967771945 630 673993 SGTC_960 1222-0186 7.7 µM 1.11606013503426 0.12822225263398 no 460 0.132198197386858 718 3126296 SGTC_2193 5925765 200 µM 1.11428948815316 0.128592259267131 no 461 0.132577507570465 629 877370 SGTC_586 0957-0265 8.15 µM 1.10940413986615 0.129616975593589 no 462 0.133627938630159 606 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2622 2-methoxyxanthone 59.94 µM 1.10798307335106 0.129916107578651 no 463 0.133934563066731 755 71034 A hepatoprotective. SGTC_3079 9117512 49.47 µM 1.10782944718281 0.129948474217948 no 464 0.133967740021409 746 7185044 SGTC_3237 9133362 49.47 µM 1.1061176376827 0.130309503457729 no 465 0.134337802761732 692 43845137 SGTC_81 0411-0046 9.971 µM 1.10576641409859 0.130383663988844 no 466 0.134413817754801 638 12925265 SGTC_308 4092-1169 104 µM 1.1055885374617 0.130421233608794 no 467 0.134452326693397 736 2268590 YDL196W YDL196W SGTC_2804 7954240 19.48 µM 1.10265754083702 0.131041372600486 no 468 0.135087955967826 756 828705 SGTC_3322 9139058 2.11 µM 1.10072263469709 0.131451873811956 no 469 0.135508695970972 725 4908926 YPR165W RHO1 SGTC_964 1287-0107 19.4 µM 1.09999003216092 0.131607531008303 no 470 0.135668232473731 754 51516812 YPR165W RHO1 SGTC_982 1491-0518 27.5 µM 1.08960405640119 0.13382794525191 no 471 0.137943797731973 655 3091256 SGTC_31 0508-1974 57.237 µM 1.08872285881523 0.134017514237574 no 472 0.138138059162041 697 6810525 SGTC_752 1896-0090 130 µM 1.08784460006293 0.134206634505747 no 473 0.13833185824965 722 772567 SGTC_785 1270-0111 65.3 µM 1.08500104836372 0.134820209239448 no 474 0.138960595472176 705 6741994 SGTC_3023 9089636 49.47 µM 1.0839805546884 0.135040877468852 no 475 0.139186710334321 766 17249241 SGTC_1980 st071811 45.7 µM 1.08252568567265 0.135355901692458 no 476 0.139509504212968 722 4974850 SGTC_2780 5215298 71.43 µM 1.07426374786182 0.137154416492829 no 477 0.141352244056404 778 2834131 SGTC_558 k064-0027 21.3 µM 1.07115691898644 0.137834936848873 no 478 0.142049439395498 748 5088526 SGTC_2607 solasodine 47.35 µM 1.07075911840838 0.137922237239385 no 479 0.142138876599558 747 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1569 carminic acid 40.6 µM 1.06865793131059 0.138383984596219 no 480 0.142611917132392 744 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_451 chloral hydrate 100 µM 1.06401475550277 0.139408081060925 no 481 0.143661007597159 795 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_983 1491-0821 12.2 µM 1.05986958181586 0.140326683831989 no 482 0.144601967890907 754 46495113 SGTC_2291 7917025 104.35 µM 1.05855979457443 0.1406177955944 no 483 0.144900152738922 748 2964612 SGTC_2749 bexarotene 57.39 µM 1.05780284167852 0.140786221816174 no 484 0.145072668507691 711 82146 An retinoic acid receptor inhibitor. SGTC_1887 st057648 70.8 µM 1.0569574232898 0.140974493850558 no 485 0.14526550964697 753 688672 SGTC_521 r062-0005 13.8 µM 1.05676241854181 0.14101794502589 no 486 0.145310014975653 725 2832033 SGTC_3011 9081274 71.4286 µM 1.05650066881105 0.141076282669869 no 487 0.145369767723494 777 6625322 SGTC_1996 st072960 66.8 µM 1.05581689722536 0.141228755924373 no 488 0.145525938433581 786 1719405 SGTC_2709 st078560 56 µM 1.05441172532357 0.141542443802948 no 489 0.145847228161584 767 17250903 SGTC_466 geldanamycin 89.2 µM 1.05320949869445 0.14181120103052 no 490 0.146122493007741 630 5288382 HSP90 inhibitor. SGTC_2254 7938975 95.19 µM 1.05308516861653 0.141839014668868 no 491 0.146150979834499 830 2969277 SGTC_3168 9103419 49.47 µM 1.05169279964242 0.142150751141864 no 492 0.146470257791484 672 16649256 SGTC_3085 9117376 49.47 µM 1.04607914458436 0.143412289176128 no 493 0.147762246595819 741 16480349 SGTC_2415 st077333 57.7 µM 1.04379855581932 0.143926951072307 no 494 0.148289299960817 846 2766255 SGTC_223 busulfan 5 mM 1.04340985697839 0.144014793091236 no 495 0.14837925513247 676 2478 A DNA alkylator. SGTC_2019 4016004 108 µM 1.04321746330664 0.144058285495701 no 496 0.148423793607223 680 45595336 SGTC_478 N-arachidonylglycine 10 µM 1.04182839936294 0.144372559322145 no 497 0.148745622437133 649 5283389 SGTC_3250 9135583 49.47 µM 1.0417334142373 0.144394066443376 no 498 0.148767646333119 733 7699353 SGTC_4 0960-0234 25.671 µM 1.04159678763908 0.144425006071496 no 499 0.14879932932553 723 6821112 SGTC_201 4262-0159 12.803 µM 1.0386978421225 0.145082536724197 no 500 0.149472642533434 690 1341029 SGTC_2110 5483698 200 µM 1.03122372572749 0.146787076300108 no 501 0.151217958527209 755 2848765 YHR062C RPP1 SGTC_1408 3909-7976 48.8 µM 1.03061445885639 0.146926614923893 no 502 0.151360826475348 837 24152374 SGTC_771 0250-0039 27.3 µM 1.0299634138438 0.147075820170847 no 503 0.151513590224572 745 3005115 SGTC_57 miconazole 162.5 nM 1.02891065470696 0.147317304387129 no 504 0.151760830567499 730 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2979 9012552 45.46 µM 1.02796657061498 0.147534086358829 no 505 0.151982776481507 720 17100905 SGTC_873 0591-4978 488 µM 1.02742339523804 0.147658907885069 no 506 0.152110569923255 846 3305145 SGTC_3289 9119912 71.43 µM 1.02711199803949 0.147730498749646 no 507 0.152183864840875 761 17014829 SGTC_2120 5538279 151.968 µM 1.02621875592274 0.147935985923924 no 508 0.152394241227133 775 2058197 SGTC_1963 st076565 50.3 µM 1.02616787204246 0.147947697337118 no 509 0.152406231206972 766 4914280 SGTC_502 l-744,832 89.3 µM 1.02596208122729 0.147995068397962 no 510 0.152454728936901 785 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2300 7976697 71.57 µM 1.0237975084874 0.148493947126448 no 511 0.152965463726052 670 2236109 SGTC_320 4092-0846 5.34 µM 1.02212958122356 0.148879128005825 no 512 0.153359787069068 798 1359356 SGTC_2437 5741531 144.16 µM 1.02198532784481 0.148912472334244 no 513 0.15339392237027 811 2262990 SGTC_2270 7924575 90.91 µM 1.02096578409348 0.149148283259755 no 514 0.153635324906884 815 1262135 SGTC_2956 9076196 2.52 µM 1.02026952287323 0.149309465198176 no 515 0.153800326672857 783 16423868 SGTC_443 clozapine 122 µM 1.0151534290539 0.150497388267015 no 516 0.155016348099007 708 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2820 7989630 71.43 µM 1.01502571682771 0.150527122520164 no 517 0.155046784446831 670 2984098 SGTC_1265 0819-1001 68.8 µM 1.01399333754587 0.150767627092751 no 518 0.155292965702776 754 3106768 SGTC_2589 lobaric acid 100 µM 1.01287922528148 0.151027459173676 no 519 0.155558926285165 755 73157 A novel microtubule depolymerizer. SGTC_2425 5628681 7.85 µM 1.01278542443609 0.151049348899796 no 520 0.15558133210359 884 5714958 SGTC_1652 st011932 78 µM 1.01265137180674 0.151080635601426 no 521 0.155613356393326 780 1551076 SGTC_2438 5259590 200 µM 1.01037493814685 0.151612593481951 no 522 0.156157845182813 833 1201127 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.00870242970509 0.152004218341158 no 523 0.156558683092859 652 88881 An O-methylated flavonoid and antioxidant. SGTC_2893 9048488 25.97 µM 1.00763906220512 0.152253559392998 no 524 0.156813884580124 757 6467338 SGTC_1347 1493-0251 600 nM 1.00761411970593 0.152259411229609 no 525 0.156819873906434 863 3986378 SGTC_3156 9099931 49.47 µM 1.00738148517858 0.152313997523909 no 526 0.156875742602575 846 18111053 SGTC_500 h-89 112 µM 1.00542109144438 0.152774508079482 no 527 0.157347064035528 858 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_82 0054-0107 293.755 µM 1.00245035935896 0.153474112531312 no 528 0.158063065129 807 3104697 SGTC_2409 alverine citrate 63.97 µM 1.00092616573564 0.153833880962764 no 529 0.158431252716547 781 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_737 1950-0117 57.9 µM 0.999374948542893 0.154200600669878 no 530 0.158806545353081 794 5393513 SGTC_2557 derrustone 83.84 µM 0.995317936661285 0.155162441060151 no 531 0.159790828386957 816 629853 An antioxidant. SGTC_1819 st053448 58.6 µM 0.994821617402766 0.155280380244831 no 532 0.159911515206517 805 2857616 SGTC_517 1365-0151 113 µM 0.99254450840002 0.155822242607671 no 533 0.160465989466483 804 768657 SGTC_220 paclitaxel 373.376 µM 0.9919812060378 0.155956478525136 no 534 0.160603346719383 729 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_882 0843-0131 351 µM 0.990828115118697 0.15623149971279 no 535 0.160884759127202 857 5425421 SGTC_354 2783-3500 4.88 µM 0.988841205705456 0.156706142275669 no 536 0.161370420097161 793 6740761 SGTC_1561 5-methoxyflavone 52.9 µM 0.988551073780216 0.156775529728199 no 537 0.161441417065203 776 94525 SGTC_720 r052-1644 49.9 µM 0.987554292646142 0.157014072229292 no 538 0.161685490376127 725 1422863 YOR257W CDC31 SGTC_1757 st041620 31.8375 µM 0.98486903650006 0.157657875745143 no 539 0.162344202193678 818 5289815 SGTC_1387 3342-1166 1.8 µM 0.983772286321636 0.157921325164924 no 540 0.16261374429162 747 3418228 SGTC_25 0118-0223 35.662 µM 0.98215430393794 0.158310506800949 no 541 0.16301191795616 817 5333628 SGTC_832 4083-0019 164 µM 0.980611321184478 0.158682234102286 no 542 0.163392224653617 992 1990758 SGTC_156 3474-0145 5.642 µM 0.979541494728071 0.158940306753797 no 543 0.163656248204281 819 2265471 SGTC_1509 1326-1131 80 µM 0.978985077746703 0.159074639063248 no 544 0.163793676343143 797 768313 SGTC_1033 k072-0102 21.3 µM 0.977946680143755 0.159325531845944 no 545 0.164050348024641 844 5965931 SGTC_2839 9003951 25.97 µM 0.97582524338973 0.159838908492024 no 546 0.164575536510772 802 2990634 SGTC_2691 st077356 60.2 µM 0.971863162376306 0.160800605934125 no 547 0.165559314097681 866 2839272 SGTC_2181 6316240 54.2555 µM 0.970916186148904 0.161031019288618 no 548 0.165795008604739 770 12779990 SGTC_3305 9127027 53.8275 µM 0.970067706150472 0.161237649978366 no 549 0.166006372372697 839 41905295 SGTC_1688 st021091 57.6 µM 0.967119757720833 0.161956908924145 no 550 0.166742084782969 858 3656366 SGTC_80 0159-0065 512.242 µM 0.967055199361952 0.161972683628986 no 551 0.166758219962863 761 1548079 SGTC_2211 7117706 200 µM 0.965768862915232 0.162287205985309 no 552 0.16707992620849 805 822771 SGTC_777 1315-0167 517 µM 0.965115332364515 0.162447153069872 no 553 0.167243524098198 794 4221767 SGTC_705 1124-0212 310 µM 0.964912717862802 0.162496762395174 no 554 0.167294265419762 849 9554485 SGTC_475 α-linolenic acid 10 µM 0.964439699764236 0.162612617295494 no 555 0.167412763294218 889 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2895 9054447 58.44 µM 0.962866128072964 0.16299841411319 no 556 0.167807354878957 806 2697450 SGTC_997 3996-0078 137 µM 0.960488289106964 0.163582523276812 no 557 0.168404761075968 852 735687 SGTC_2682 pyrogallin 40.03 µM 0.959575328304332 0.16380715007128 no 558 0.168634495479495 896 822798 An ATP competetive kinase inhibitor. SGTC_2039 Aminomethylbenzodioxan 200 µM 0.957154357075936 0.164403779749879 no 559 0.169244675441731 805 15053 SGTC_3135 9127742 49.47 µM 0.95711665036391 0.164413083405661 no 560 0.169254190212386 791 3643468 SGTC_2304 7443016 91.4 µM 0.956385026747794 0.164593669863724 no 561 0.169438873348246 777 939854 SGTC_2913 7966556 36.57 µM 0.954544073631605 0.165048640215713 no 562 0.169904155460936 840 2976516 SGTC_1919 st067113 52.3 µM 0.951196759456309 0.165877974423912 no 563 0.170752251576336 831 1268243 SGTC_3157 9099274 49.47 µM 0.948865069329052 0.166457265337517 no 564 0.171344621159322 844 17217662 SGTC_321 4534-3890 65.3 µM 0.948534349436368 0.166539535849948 no 565 0.17142874732703 868 699746 SGTC_2046 4110841 106 µM 0.94630231463363 0.167095467280452 no 566 0.171997206567277 875 44119630 YMR134W ERG29 SGTC_2358 9037157 4 µM 0.944006311331164 0.167668578312274 no 567 0.172583211555275 845 2388925 SGTC_2461 5755302 26.15 µM 0.94281728573544 0.167965870880732 no 568 0.172887184279085 875 2788904 SGTC_2872 9044037 25.97 µM 0.939126087997391 0.168890942610287 no 569 0.173833005738039 837 6465195 SGTC_2247 cerulenin 830 nM 0.934529937711468 0.170047375668027 no 570 0.175015300253502 865 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_319 1348-1596 45.5 µM 0.934192113991125 0.170132574939549 no 571 0.175102401432931 905 5380505 SGTC_485 niflumic acid 177 µM 0.933727720277165 0.170249739852825 no 572 0.175222181060333 830 4488 A COX2 inhibitor. SGTC_749 1000-0129 128 µM 0.933254553630381 0.170369171302236 no 573 0.175344276894147 923 708470 SGTC_315 k915-0449 187 µM 0.933157574296416 0.17039365636948 no 574 0.175369308082757 959 20970215 YNL149C PGA2 SGTC_2875 9039966 71.43 µM 0.931796529417828 0.170737526877853 no 575 0.175720844287777 884 6463691 SGTC_587 k089-0003 57 µM 0.931077820581546 0.170919289068743 no 576 0.175906655315575 761 9659696 SGTC_1654 st012436 41.8 µM 0.93029573654415 0.171117219515963 no 577 0.17610899233557 839 4323132 SGTC_3262 9137218 49.47 µM 0.930210796186343 0.171138725110509 no 578 0.176130976562408 729 17650664 SGTC_2343 7990716 14.84 µM 0.928985367356225 0.171449177208375 no 579 0.176448334820867 884 6456862 SGTC_2334 9017922 200 µM 0.926518267943994 0.172075287107463 no 580 0.177088353989199 913 3163164 SGTC_1445 4239-0156 97.7 µM 0.924441706774434 0.17260341444227 no 581 0.177628194290864 965 4008346 SGTC_394 menadione 8.33 µM 0.92224398799967 0.173163479994014 no 582 0.178200661588077 892 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3112 9123419 49.47 µM 0.922215626217435 0.173170715252748 no 583 0.178208056928292 936 17015854 SGTC_1655 st012546 55.1 µM 0.922031155445389 0.173217779538495 no 584 0.178256162438431 837 720985 YLR208W SEC13 SGTC_2779 methotrexate 400 µM 0.921910596986822 0.173248542187212 no 585 0.178287605586345 945 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1423 4048-0112 5.59 µM 0.918884377830713 0.174021875633114 no 586 0.179078025987385 916 X1423 SGTC_3039 9090270 49.47 µM 0.918637392373225 0.174085088110693 no 587 0.179142633464101 869 17173750 SGTC_1061 3448-9325 110 µM 0.917794458809675 0.174300935077424 no 588 0.179363241903905 881 723482 SGTC_2158 5657123 3.6195 µM 0.917097961552146 0.174479412871463 no 589 0.179545654575195 900 2858827 SGTC_1233 0325-0408 14.2 µM 0.917082547748767 0.174483363979217 no 590 0.17954969276947 891 12874 SGTC_2013 4024628 200 µM 0.91703822381574 0.174494726101352 no 591 0.179561305319022 825 5230760 SGTC_3288 9119690 36.221 µM 0.913908482664746 0.175298200692518 no 592 0.180382468009531 819 17595618 YKL019W RAM2 SGTC_812 4251-0442 148 µM 0.911048709275979 0.17603441620424 no 593 0.181134854755562 897 5723007 SGTC_2470 5664817 21.68 µM 0.910228103159287 0.176246032673578 no 594 0.181351113058999 895 2859561 SGTC_2213 7173844 200 µM 0.91004326449589 0.176293720750824 no 595 0.181399846786161 919 892728 SGTC_2421 5690543 90.72 µM 0.909530033750727 0.176426176261659 no 596 0.181535205870489 890 3397993 SGTC_3124 9127567 49.47 µM 0.907637017671106 0.176915273410024 no 597 0.182035014895046 872 17592030 SGTC_332 4112-0506 40.9 µM 0.906999189548907 0.177080261399182 no 598 0.182203612904527 898 2790355 SGTC_90 0870-0863 4.608 µM 0.906750763972437 0.177144548322619 no 599 0.182269305989225 929 1738164 SGTC_1774 st048371 48.465 µM 0.905874550122303 0.177371410337606 no 600 0.182501128103146 925 4242727 SGTC_1508 1080-0625 72.9 µM 0.905742563592255 0.177405599083932 no 601 0.182536064066531 857 767111 SGTC_2106 5357045 167.29 µM 0.899524158330617 0.179021079228803 no 602 0.184186766907154 918 668842 SGTC_129 0088-0017 176.636 µM 0.897342013139296 0.179590166052512 no 603 0.184768222224356 879 182446 SGTC_1273 0849-0096 14.1 µM 0.896865162586352 0.179714676243452 no 604 0.18489543577518 899 5286025 SGTC_1880 MG-132 525 µM 0.893724295626241 0.180536140887874 no 605 0.185734711428189 869 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_40 0327-0103 19.753 µM 0.893335399615021 0.180638016638564 no 606 0.185838793074911 877 409036 SGTC_1951 sophoraflavanone G 9.2 µM 0.891334800809387 0.181162665892197 no 607 0.186374792069247 919 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1692 fluoroquinolonic acid 71 µM 0.890725909516804 0.181322534535608 no 608 0.186538115695076 915 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3066 9117245 49.47 µM 0.887513729191033 0.182167376374541 no 609 0.187401188944307 962 17176980 SGTC_3268 9137683 49.47 µM 0.886885510289436 0.182332892664947 no 610 0.187570271747696 903 1953228 SGTC_2851 9015922 71.43 µM 0.886757345771369 0.182366671596963 no 611 0.187604778329407 904 2996893 SGTC_2274 7947094 46.08 µM 0.885061595072089 0.182813970255593 no 612 0.188061705702993 1007 2971028 SGTC_373 0844-0104 25.9 µM 0.884638030116406 0.182925803407312 no 613 0.18817594424664 981 5375804 SGTC_2731 amoxapine 43.43 µM 0.884381074394974 0.182993667801048 no 614 0.188245267935064 887 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1501 4491-0275 38.4 µM 0.883714084562498 0.183169899316257 no 615 0.188425287619608 951 5104718 SGTC_663 1486-0733 13.9 µM 0.879700173326137 0.184232685815785 no 616 0.189510877733994 934 722445 YPR165W RHO1 SGTC_963 1269-2853 151 µM 0.877612718182934 0.184786907119463 no 617 0.190076962493507 907 3668223 SGTC_3123 9126162 49.47 µM 0.876446073694172 0.18509710330047 no 618 0.190393790202709 930 25239884 SGTC_1678 st019265 80.2 µM 0.875965032850375 0.185225100173648 no 619 0.190524521697227 974 5367020 SGTC_1023 4482-3888 16 µM 0.872789646451118 0.186071395415835 no 620 0.191388871979808 947 3303168 SGTC_1954 st077032 68.9 µM 0.872487918306352 0.186151935683691 no 621 0.191471128172073 851 698907 SGTC_778 3456-2434 196 µM 0.870992943329492 0.186551307886651 no 622 0.191879003069273 1028 5539063 SGTC_3088 9117578 49.47 µM 0.869977528814975 0.186822871185153 no 623 0.192156342289879 974 678341 SGTC_1208 2323-2347 50.3 µM 0.869223458428654 0.187024698617973 no 624 0.192362459433594 966 5412760 SGTC_1960 st011366 51.8 µM 0.868219943714663 0.187293499091652 no 625 0.192636969131684 996 3972846 SGTC_772 k072-0172 35.3 µM 0.868188520861954 0.187301919841321 no 626 0.192645568662056 878 5861980 SGTC_2073 5212005 126 µM 0.868116892652118 0.187321115766072 no 627 0.192665172118387 844 691789 SGTC_2575 plumbagin 510 nM 0.866861322983787 0.187657798296297 no 628 0.193008998712024 916 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_884 0851-0618 334 µM 0.866511981108844 0.187751541182261 no 629 0.193104729467072 967 9642473 SGTC_2792 7535235 81.82 µM 0.865070644682883 0.188138617177908 no 630 0.193500007809904 874 1281891 SGTC_2852 9023854 51.95 µM 0.863628836171241 0.188526312299764 no 631 0.193895909025052 933 19798528 SGTC_2055 5235184 200 µM 0.86279973268762 0.188749477026129 no 632 0.194123793083919 927 2836034 SGTC_425 3825-7017 13.1 µM 0.861712576864135 0.189042346724383 no 633 0.194422851475729 968 3397440 SGTC_1502 4534-4282 27.7 µM 0.86137483442312 0.189133388361191 no 634 0.194515815844047 923 3278949 SGTC_2477 5967686 25.23 µM 0.861304626239219 0.189152317023668 no 635 0.194535144200913 942 776118 SGTC_3003 9075612 71.4286 µM 0.861287415044813 0.189156957471138 no 636 0.194539882631869 926 6501993 SGTC_2876 9059903 25.97 µM 0.860890796889462 0.189263912277866 no 637 0.194649095427594 991 6916095 SGTC_2482 5981709 142.65 µM 0.858247448130057 0.189977686635504 no 638 0.195377920475729 941 877755 SGTC_3228 9131799 49.47 µM 0.857854233075426 0.190084006345419 no 639 0.195486479336077 916 17015818 SGTC_3281 9140613 49.47 µM 0.856548211090749 0.190437398300474 no 640 0.195847308863526 898 16013766 SGTC_2678 equilin 100 µM 0.856476582219093 0.190456791771727 no 641 0.195867110269659 1000 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2051 5263410 176 µM 0.855745648696516 0.190654760879363 no 642 0.196069242250606 1008 227584 SGTC_2049 5262831 67.185 µM 0.855502168974978 0.190720733984766 no 643 0.196136602090254 961 763417 SGTC_70 0141-0289 43.283 µM 0.854469383079371 0.191000732696755 no 644 0.19642248327862 1079 352408 SGTC_699 0375-0592 111 µM 0.853479788040066 0.191269258324776 no 645 0.196696645770753 1013 762578 SGTC_1679 SEC14.276 6.7 µM 0.852500608787354 0.191535185284252 no 646 0.196968150630859 1025 1005053 YMR079W SEC14 SGTC_1606 st000094 49.2 µM 0.852015306427406 0.191667068329013 no 647 0.197102798335225 1029 1242210 SGTC_571 k831-0106 44.2 µM 0.850290180730366 0.192136328866483 no 648 0.197581887213981 922 4783639 SGTC_1374 2889-5571 141 µM 0.84446898240075 0.193724964550963 no 649 0.199203694490458 979 2853281 SGTC_1967 st070177 51.4 µM 0.844048293379462 0.193840082258064 no 650 0.199321209848855 972 5729214 SGTC_3098 9119039 49.47 µM 0.843530089644599 0.193981941275961 no 651 0.199466022354214 983 17161528 SGTC_1327 1436-0082 2.18 µM 0.84003703073404 0.194939820625208 no 652 0.200443812084811 969 15992205 SGTC_2832 7992762 51.95 µM 0.83881116267061 0.195276663266561 no 653 0.200787642836869 846 2985177 SGTC_988 1497-1057 103 µM 0.838311564898606 0.195414043551283 no 654 0.200927871192014 1003 3533044 SGTC_985 1493-0307 8.71 µM 0.838219856220821 0.195439268142639 no 655 0.200953618595153 961 3278274 SGTC_889 0919-1524 82.7 µM 0.83738280422289 0.195669591778044 no 656 0.201188714166103 941 3905452 SGTC_161 4065-0411 162.148 µM 0.835920654464724 0.196072312725785 no 657 0.201599770985149 981 1906281 YLR208W SEC13 SGTC_748 act1.228 77.9 µM 0.835838102442919 0.196095065071342 no 658 0.201622993980367 988 4421505 YNR035C ARC35 SGTC_3224 9130643 49.47 µM 0.831818360109383 0.197204891638551 no 659 0.202755739451495 982 17644395 SGTC_1634 st006576 41 µM 0.8314019971631 0.197320063729679 no 660 0.20287328560672 991 3915356 SGTC_1924 st058459 75.1 µM 0.830942613248957 0.197447183247186 no 661 0.20300302451568 994 688683 SGTC_2215 7188065 200 µM 0.828795168697115 0.198042075015997 no 662 0.203610161264798 1004 940217 SGTC_1070 indatraline 8.81 µM 0.828722684089946 0.198062173792935 no 663 0.20363067336595 977 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2597 laccaic acid a 100 µM 0.828631613221705 0.198087427977088 no 664 0.203656446858253 973 5491415 A textile dye. SGTC_2303 7774051 200 µM 0.827830247150032 0.198309732651983 no 665 0.203883321149837 970 2953184 SGTC_1520 flindersine 88 µM 0.827771466250729 0.198326044818579 no 666 0.203899968504054 1034 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3042 9091578 49.47 µM 0.82658750048217 0.198654777115223 no 667 0.204235452214725 978 25236497 SGTC_2697 mebhydrolin 72.4 µM 0.822052540641873 0.199916961457169 no 668 0.205523497352641 1018 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2919 7978188 46.38 µM 0.819799853946151 0.200545725020535 no 669 0.206165107169469 1021 2980291 SGTC_675 1309-0189 238 µM 0.817989197022244 0.201051970293168 no 670 0.206681677940551 990 4246530 SGTC_2545 solidagenone 89.61 µM 0.816430474363576 0.201488390111746 no 671 0.207126986499012 826 6708572 An anti ulcer agent SGTC_234 nsc-17383 10.7 µM 0.814434810673261 0.202047974996664 no 672 0.207697951643462 1062 408974 SGTC_636 0kpi-0074 126 µM 0.813331891972243 0.202357632479011 no 673 0.208013898399013 977 616434 SGTC_936 3005-4620 401 µM 0.81280647524745 0.202505249199998 no 674 0.208164511216838 1050 777207 SGTC_1353 1498-1206 8.11 µM 0.809964103153711 0.203304933983312 no 675 0.208980403658696 1051 6756808 SGTC_1512 0259-0544 12.2 µM 0.809399959304979 0.203463876400591 no 676 0.209142562804789 1052 18476 SGTC_651 3253-0966 34.4 µM 0.808142567037637 0.203818401899902 no 677 0.209504257760265 1039 781462 SGTC_2131 toluylene red 5.2905 µM 0.807261426645196 0.204067061342166 no 678 0.209757941194224 991 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1540 guanosine 70.6 µM 0.80592989821117 0.204443163821469 no 679 0.21014163540896 988 6802 Guanosine is a purine nucleoside SGTC_2695 st077686 51.995 µM 0.805455735161601 0.20457719510246 no 680 0.210278370068352 1032 2876092 SGTC_1677 st019204 53.9 µM 0.803750349263048 0.205059687149322 no 681 0.210770584812871 954 3945625 SGTC_906 1165-0455 526 µM 0.802849203550387 0.205314914442047 no 682 0.211030949465155 1009 3252859 SGTC_649 1123-0311 367 µM 0.802265924874882 0.205480214289222 no 683 0.211199574448294 1049 693629 YIL048W NEO1 SGTC_1234 0326-0494 15.5 µM 0.800711810305229 0.20592103242594 no 684 0.211649251868727 1045 1547813 SGTC_435 c-PAF 6.7 µM 0.800405950699847 0.206007854250661 no 685 0.211737817191976 1020 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2719 novobiocin 32.65 µM 0.800261773232167 0.206048788238277 no 686 0.211779573030082 1007 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2941 9056145 11.23 µM 0.799680274649549 0.206213932721285 no 687 0.211948032161464 966 2119517 SGTC_1632 st005650 90 µM 0.798407209896924 0.206575754477711 no 688 0.212317110327903 1012 2759605 SGTC_852 0418-0143 439 µM 0.796947854610174 0.206990984695782 no 689 0.212740658283716 1104 5369229 SGTC_278 4092-0821 23.9 µM 0.796501553220273 0.20711806933463 no 690 0.21287028654463 1040 877900 SGTC_2621 lithochol-11-enic acid 100 µM 0.795896685217844 0.207290379577152 no 691 0.21304604404373 1059 6708711 SGTC_1122 capsaicin 818.572 nM 0.795383744268924 0.207436568732894 no 692 0.213195156463468 1045 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1146 3579-1023 7 µM 0.795215108807099 0.207484643471701 no 693 0.213244192243285 1091 X1146 SGTC_2434 5670830 169.91 µM 0.794205181138027 0.207772692282644 no 694 0.213537996377852 1002 1549830 SGTC_3092 9117248 49.47 µM 0.793789404904154 0.207891347448593 no 695 0.213659020856701 1116 17141857 SGTC_492 tmb-8 126 µM 0.793752733187847 0.207901814826166 no 696 0.213669697206509 926 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2971 9092186 9.93 µM 0.791118037735795 0.208654662187889 no 697 0.214437557122492 969 25236400 SGTC_405 ebelactone b 50 µM 0.790339086854345 0.208877549820629 no 698 0.214664882783245 1026 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_419 nsc-638432 893 µM 0.788577032695949 0.20938225813117 no 699 0.215179629489364 1027 368090 SGTC_846 0335-0850 148 µM 0.78636097885747 0.210018024102376 no 700 0.215828018612276 1048 6819598 SGTC_564 3555-0129 330 µM 0.786089952688718 0.210095856849155 no 701 0.215907395052689 967 563260 SGTC_1731 st035964 63 µM 0.785615021565537 0.210232287465434 no 702 0.21604653067912 997 6739575 SGTC_535 2293-4129 48.2 µM 0.785548188268361 0.210251490441207 no 703 0.216066114302101 1116 396118 YIL048W NEO1 SGTC_1204 4049-0315 18.3 µM 0.783652213315262 0.210796683217002 no 704 0.216622104766652 1021 588402 SGTC_1659 st012954 42.1 µM 0.782605935355563 0.211097897998022 no 705 0.2169292774945 1019 24207262 SGTC_2014 4013930 200 µM 0.782350509680458 0.211171471231285 no 706 0.217004305154753 1080 64556 SGTC_891 0929-0073 133 µM 0.781479881100017 0.211422361395572 no 707 0.217260152568097 1084 5603632 SGTC_2563 tomatine 8.54 µM 0.781028749883054 0.211552433096279 no 708 0.21739279281524 1069 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1084 voriconazole 435 nM 0.779658513752559 0.2119477914276 no 709 0.217795952089896 1102 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1496 4469-0713 57.4 µM 0.778635938116126 0.212243119641271 no 710 0.218097101375445 1057 746691 SGTC_2243 6634756 200 µM 0.778337514736866 0.212329352075635 no 711 0.218185032504853 1036 885676 SGTC_2251 lansoprazole 556 µM 0.777290126731428 0.212632167355759 no 712 0.218493809404623 896 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1968 st069590 43.6 µM 0.777115355946904 0.212682720701673 no 713 0.218545357472458 1046 6384066 SGTC_2093 5331342 194.4 µM 0.776662423430519 0.212813766412301 no 714 0.218678981011214 1081 33839 SGTC_2490 carminic acid 95.39 µM 0.77594734356322 0.213020754408132 no 715 0.21889003860683 1032 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1404 3909-7820 48.3 µM 0.775341347088219 0.213196258889605 no 716 0.219068991670031 1065 23741373 SGTC_153 4077-0274 519.67 µM 0.775051787652667 0.213280148842964 no 717 0.219154529367639 1050 3121976 SGTC_169 k015-0017 16.025 µM 0.77448611789089 0.213444087846274 no 718 0.219321687195737 1060 1840002 SGTC_2371 9071574 200 µM 0.773443822619605 0.213746351856519 no 719 0.219629881706773 1060 45596039 SGTC_26 0302-0163 425.158 µM 0.773438918287594 0.213747774694236 no 720 0.219631332447959 1096 3100915 SGTC_1516 st013856 110 µM 0.77320959331911 0.213814312282261 no 721 0.219699174778038 1020 5281404 A mutagen and neurotoxin. SGTC_721 1187-1332 279 µM 0.772347927334453 0.214064428497441 no 722 0.219954193166685 967 25730 SGTC_159 3970-0959 50 µM 0.769847755252338 0.214791117825422 no 723 0.220695103982935 1214 6615653 SGTC_1337 1486-1011 40.3 µM 0.769757940857873 0.214817249534088 no 724 0.22072174650495 1117 X1337 SGTC_3333 9141820 12.094 µM 0.769578223619028 0.214869544231281 no 725 0.2207750633172 1017 1939433 SGTC_1685 st024049 53.0905 µM 0.767909100940083 0.21535558404596 no 726 0.221270595070758 1059 1941139 SGTC_379 3970-0972 5.9 µM 0.766524493746327 0.215759258066438 no 727 0.221682141725377 1056 2898042 YBL034C STU1 SGTC_155 k072-0202 43.6 µM 0.766193802535472 0.215855733974932 no 728 0.221780497704289 1051 5857737 SGTC_2568 diosmetin 100 µM 0.765384668674404 0.216091896212184 no 729 0.222021259789371 1100 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1596 piperlongumine 63 µM 0.764710231177613 0.216288858871035 no 730 0.222222056230456 1120 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2986 9022445 71.43 µM 0.76057419889362 0.21749901618734 no 731 0.223455717681875 1075 6459286 SGTC_2159 5658611 73.75 µM 0.760009646646354 0.217664500549019 no 732 0.223624409331765 1129 793844 SGTC_1417 3966-0327 90.4 µM 0.759380699722699 0.217848946122555 no 733 0.223812427754778 1132 651118 SGTC_1158 4092-0494 91.8 µM 0.759323084754918 0.217865846848704 no 734 0.223829655758958 1137 1148199 SGTC_182 3448-4371 550.524 µM 0.756622519591937 0.218658876354014 no 735 0.224638022871706 1135 3491403 SGTC_2930 9013230 14.89 µM 0.755986385575555 0.218845920629381 no 736 0.224828679205109 1096 2995857 SGTC_114 0364-0001 490.298 µM 0.753905520995476 0.219458405787672 no 737 0.225452977594902 1124 4003655 SGTC_3297 9117502 71.43 µM 0.75152006238541 0.220161755729279 no 738 0.226169865697298 1121 7453720 SGTC_2231 micatex 6.853 µM 0.750896041769521 0.220345960652288 no 739 0.226357611342757 1110 20737 An antifungal of unknown mechanism. SGTC_2165 5727197 32.143 µM 0.750813312775785 0.220370388091976 no 740 0.226382508166215 1178 1361712 SGTC_1339 1486-1321 22.7 µM 0.749323536082561 0.220810540945586 no 741 0.22683111265268 1097 3469382 SGTC_2572 astragaloside iv 100 µM 0.745661649094438 0.221894578117799 no 742 0.227935915850233 1087 45006101 An anti-inflammatory agent. SGTC_113 0099-0221 2.5 µM 0.745395489871295 0.22197348817549 no 743 0.228016334792958 1089 89219 SGTC_2909 7941780 10.49 µM 0.744625685981973 0.222201807402368 no 744 0.228249017757768 1136 1243215 SGTC_2641 levomentholum 100 µM 0.743744201613016 0.222463414907908 no 745 0.228515621409859 1096 16666 SGTC_2714 st079313 56.9 µM 0.742529921383591 0.222824077266744 no 746 0.22888316497994 1103 2939799 SGTC_3239 9133757 49.47 µM 0.739380100896192 0.223761180126883 no 747 0.229838111040851 1129 17036923 SGTC_927 2425-1185 123 µM 0.738081062589547 0.224148308473543 no 748 0.230232595404734 1143 730375 SGTC_1427 4048-4900 550 nM 0.737921017367828 0.224196030093931 no 749 0.230281223191411 1123 24132586 SGTC_2268 7933382 153.85 µM 0.737103899914556 0.224439764690861 no 750 0.230529583857133 1198 935025 YOR257W CDC31 SGTC_2116 5511452 16.8835 µM 0.736475891213532 0.224627192974657 no 751 0.230720567121995 1116 870744 SGTC_3175 9106517 49.47 µM 0.735924131745291 0.224791938031292 no 752 0.230888435202845 1116 41468073 SGTC_1 0258-0098 57.368 µM 0.735589077839731 0.224892012284317 no 753 0.230990405748643 1038 6790032 YDR047W HEM12 SGTC_1993 st073995 70.8 µM 0.734893721540447 0.225099782610159 no 754 0.231202111188668 1137 3098394 SGTC_1838 st055369 84.5 µM 0.733452986882792 0.225530615624873 no 755 0.231641095910958 1138 676036 SGTC_1759 st043059 70 µM 0.733239578734757 0.225594472225403 no 756 0.231706159793838 1147 669426 SGTC_1469 k284-2957 126 µM 0.732103887340926 0.225934469126002 no 757 0.232052580659189 1164 23884841 SGTC_1834 st055981 52.8 µM 0.72915715206765 0.226817995915016 no 758 0.232952768964397 1149 471719 YDL150W RPC53 SGTC_181 1447-1644 8.07 µM 0.728653128959239 0.226969313361485 no 759 0.233106935316357 1120 534600 SGTC_98 0074-0023 107.663 µM 0.728465892406826 0.22702553988039 no 760 0.233164220086075 1147 3563821 SGTC_255 tunicamycin 200.472 nM 0.728031106097263 0.227156135064175 no 761 0.233297272506988 1137 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3227 9130768 49.47 µM 0.723725022198129 0.228451822026488 no 762 0.234617284077718 1152 17720899 SGTC_534 k292-0788 63.4 µM 0.721564096586221 0.229103599177829 no 763 0.23528125989373 1209 4146317 SGTC_961 1252-1571 372 µM 0.719608414086146 0.229694369080099 no 764 0.235883064989005 1138 6813498 SGTC_2645 abamectin 100 µM 0.718898896308567 0.229908909978295 no 765 0.236101608274789 1153 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2190 6049624 200 µM 0.718031156222002 0.230171445863981 no 766 0.236369038230706 1100 2265554 SGTC_1297 1068-0111 14.1 µM 0.717064671612365 0.230464054345458 no 767 0.236667096594279 1141 767057 SGTC_3074 9116018 49.47 µM 0.716339163880857 0.230683842322952 no 768 0.236890974841691 1204 17027303 SGTC_1247 0448-0043 5.84 µM 0.716039518889006 0.230774652035955 no 769 0.236983473699094 1185 3089013 YGL099W LSG1 SGTC_477 mead ethanolamide 10 µM 0.715699563720035 0.230877702229125 no 770 0.237088440132512 1038 16061185 SGTC_1982 st072467 71.9 µM 0.715102024937086 0.231058895686155 no 771 0.23727300140373 1132 3163533 SGTC_1826 st055655 41.6 µM 0.714687221821511 0.231184724321774 no 772 0.237401167658867 1148 676168 SGTC_58 0957-0393 9 µM 0.713209239819262 0.231633374094579 no 773 0.237858144771722 1157 6997992 SGTC_39 0986-0283 58.349 µM 0.712214737183591 0.231935533876303 no 774 0.238165906232766 1204 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.712213282701133 0.231935975952464 no 775 0.238166356500552 1189 364106 SGTC_707 0865-0008 204 µM 0.71067547793123 0.232403639572321 no 776 0.23864267944045 1183 723043 SGTC_602 3130-1533 38.1 µM 0.710651046379533 0.232411073710459 no 777 0.238650251126193 1186 720941 SGTC_306 1672-3436 11.6 µM 0.710606759820978 0.23242454975307 no 778 0.2386639764964 1194 6797378 SGTC_2342 7990637 118.86 µM 0.708506236744195 0.233064220903749 no 779 0.239315470270499 1208 2033102 YER133W GLC7 SGTC_1760 st045453 10.4495 µM 0.707856242535454 0.233262361156348 no 780 0.239517267741806 1195 3323419 YIL048W NEO1 SGTC_2492 derrusnin 100 µM 0.707854087324376 0.233263018293157 no 781 0.239517937004028 1111 1715307 Part of coumarin class of compounds. SGTC_978 1416-0512 87.4 µM 0.706463358267466 0.233687274113686 no 782 0.239950015850638 1202 6814003 SGTC_932 2857-0803 154 µM 0.706137879149565 0.233786626513311 no 783 0.240051198722106 1217 674898 SGTC_2097 5376186 200 µM 0.705608886619108 0.233948151251729 no 784 0.240215698160512 1137 742755 SGTC_2925 9010536 32.5 µM 0.704891165298267 0.234167402022306 no 785 0.240438984284808 1172 2994177 SGTC_3022 9087993 49.47 µM 0.703381449751103 0.234628963716353 no 786 0.240909031892167 1191 17173644 SGTC_2763 lisinopril 49.32 µM 0.703141474832158 0.234702376985095 no 787 0.240983793727869 1153 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2020 4017018 200 µM 0.703045301591893 0.234731801924059 no 788 0.241013759100267 1204 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_146 3448-8650 53.125 µM 0.700565978827767 0.235491073337846 no 789 0.241786958121438 1202 2891488 YIL048W NEO1 SGTC_701 4424-0219 185 µM 0.70023090383377 0.235593791041423 no 790 0.241891557419985 1231 2911779 SGTC_682 0kpi-0099 17 µM 0.699602857206368 0.235786386165991 no 791 0.242087678858133 1211 1714895 YML126C ERG13 SGTC_187 1488-2104 32.728 µM 0.697333680874372 0.236482968713486 no 792 0.242796997316182 1218 2852859 SGTC_1375 2910-0797 186 µM 0.696730667479858 0.236668269618014 no 793 0.242985681369878 1178 742508 SGTC_1717 st033143 58.0435 µM 0.694810458153666 0.237258865446034 no 794 0.243587046647294 1214 674616 SGTC_3005 9076496 71.4286 µM 0.694611897050774 0.2373199827254 no 795 0.243649277228096 1203 21368410 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.694572506299627 0.237332108260321 no 796 0.243661623613616 1179 2333 A French combination drug. SGTC_2255 7941087 197.44 µM 0.693898263056993 0.237539711244813 no 797 0.243873006477972 1217 935561 SGTC_907 3448-6986 75.5 µM 0.693630465467769 0.237622195155057 no 798 0.243956991493785 1233 590582 SGTC_1377 2944-0135 198 µM 0.693441112120858 0.237680527062565 no 799 0.244016384729963 1242 1894137 SGTC_1464 k208-0027 110 µM 0.691333333782519 0.238330376248065 no 800 0.244678044240254 1209 X1464 SGTC_3146 9095609 49.47 µM 0.689844245902968 0.238790062916119 no 801 0.245146070324651 1224 17173999 SGTC_802 4112-3352 742 µM 0.689505546337985 0.238894688328463 no 802 0.245252592076667 1229 704594 SGTC_1514 1189-1591 158 µM 0.689264627692383 0.238969124147943 no 803 0.245328376659011 1220 767698 YMR146C TIF34 SGTC_29 0299-0004 12.984 µM 0.686752879043851 0.239745925437169 no 804 0.246119234134062 1104 16871 A napthoquinone isolated from Swertia calycina. SGTC_2091 4-phenylthiadiazole 200 µM 0.685655546375831 0.240085726322032 no 805 0.246465172628081 1210 270010 SGTC_2904 7225135 42.03 µM 0.685552913929112 0.240117520986107 no 806 0.246497541234453 1290 4446116 SGTC_2791 5663188 71.43 µM 0.685548534196654 0.240118877841247 no 807 0.24649892258159 1192 54690634 SGTC_1556 plumbagin 1.48 µM 0.685314652359258 0.240191341253858 no 808 0.246572693843479 1150 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2857 9024691 58.44 µM 0.679860212765437 0.241884661052274 no 809 0.248296488203912 1241 16478292 SGTC_406 estrone 100 µM 0.677228356745631 0.242704026107716 no 810 0.249130539348653 1244 5870 A steroid. SGTC_1279 0874-0590 65.2 µM 0.676402340571554 0.242961495816382 no 811 0.249392615809855 1236 3523074 SGTC_2150 5556613 200 µM 0.675764304679849 0.243160473065113 no 812 0.249595150598258 1232 743190 SGTC_3109 9122853 49.47 µM 0.674442695874194 0.243572908807474 no 813 0.250014952998419 1265 1234709 SGTC_1491 4138-0063 26.5 µM 0.673503231063409 0.243866318085099 no 814 0.250313596939678 1207 23883227 SGTC_3083 9117465 49.47 µM 0.672493950027126 0.244181744443712 no 815 0.250634645183214 1222 16420915 SGTC_713 1488-1073 324 µM 0.67233817764248 0.244230446920622 no 816 0.250684215175369 1214 3312542 SGTC_3077 9117319 49.47 µM 0.671123554667958 0.244610380225439 no 817 0.251070911329563 1238 17154678 SGTC_1222 0366-0074 1.18 µM 0.670705240094517 0.244741302413899 no 818 0.251204162002872 1262 286520 SGTC_1560 lithocholic acid 53.1 µM 0.670601046465713 0.244773918328485 no 819 0.251237357844994 1183 9903 A bile acid which acts as a detergent. SGTC_1657 st012939 43.4 µM 0.67027728604886 0.244875280550042 no 820 0.251340521943999 1261 24207257 SGTC_1312 1218-2183 165 µM 0.669959612861047 0.244974758947335 no 821 0.251441768150575 1254 6744073 SGTC_1112 tnp00069 1.16933 µM 0.669713086430862 0.245051972934117 no 822 0.251520353894448 1269 145826 SGTC_2456 5770359 74.46 µM 0.669568847679158 0.245097155697779 no 823 0.251566339198969 1245 3118787 SGTC_1811 st050069 61.5 µM 0.666961452248362 0.245914693907451 no 824 0.25239837813474 1229 3877702 SGTC_590 k048-0076 22.4 µM 0.666924461509875 0.24592630272133 no 825 0.252410192575577 1243 6832814 SGTC_1713 st033146 12.748 µM 0.66370178225702 0.246938804985918 no 826 0.253440599225644 1259 674619 SGTC_3311 9131146 2.8755 µM 0.663694395812084 0.24694112822085 no 827 0.253442963474694 1239 4900406 YPR165W RHO1 SGTC_1261 0712-0010 12.7 µM 0.663462798304373 0.247013977777726 no 828 0.253517098950442 1262 2840123 SGTC_305 1682-2595 20.8 µM 0.662940539205759 0.247178297833717 no 829 0.253684318406179 1252 226033 SGTC_2889 9059656 51.95 µM 0.659628976353557 0.248221584608427 no 830 0.254745977304264 1306 3949838 SGTC_1343 1487-0095 224 µM 0.658160827908766 0.248684865602177 no 831 0.255217396398207 1250 4560101 YGL055W OLE1 SGTC_1097 itavastatin 7.23 µM 0.656073205149126 0.249344416694851 no 832 0.255888511888551 1279 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1036 k216-0215 33.5 µM 0.655989813253923 0.249370782334169 no 833 0.255915339293048 1253 622330 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.655822181360719 0.249423786236897 no 834 0.25596927137919 1386 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_631 k072-0230 41.5 µM 0.654958216567156 0.249697060123749 no 835 0.256247328152224 1275 5773147 SGTC_1071 trifluoperazine 6.31 µM 0.654619068070624 0.249804376952767 no 836 0.256356522077818 1304 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3201 9113999 49.47 µM 0.652752810913048 0.25039535495378 no 837 0.25695782504585 1269 16649224 SGTC_391 gliotoxin 8.33 µM 0.652629764491027 0.25043434545189 no 838 0.256997496036516 1310 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2992 9074591 71.4286 µM 0.651708369918084 0.250726415812553 no 839 0.257294661043272 1274 17741321 SGTC_1625 st003711 30.1 µM 0.650773890694938 0.251022817981919 no 840 0.257596228381258 1331 24207034 YER133W GLC7 SGTC_2183 6420625 130.508 µM 0.648381035174614 0.251782638656819 no 841 0.258369266684549 1265 2897619 SGTC_2934 9036370 36.88 µM 0.64810158375666 0.251871454003292 no 842 0.258459624862499 1267 6462800 SGTC_1870 st057514 26.5 µM 0.64709698667218 0.252190871930232 no 843 0.258784587708051 1276 5393161 SGTC_3276 9139060 49.47 µM 0.645001878360539 0.252857711456716 no 844 0.259462984229373 1320 4870619 SGTC_851 0394-0702 453 µM 0.644343192402354 0.253067552291648 no 845 0.259676456510883 1274 762646 SGTC_2107 5363541 170.161 µM 0.643839626581593 0.253228037508536 no 846 0.259839717326654 1254 244052 SGTC_2854 9024559 71.43 µM 0.64320575338456 0.253430127428353 no 847 0.260045300288651 1244 3163529 SGTC_143 4032-1194 15.74 µM 0.641117747014489 0.254096419543087 no 848 0.260723092320456 1307 1806963 SGTC_2686 alizarin 95.37 µM 0.641086835378431 0.25410629048131 no 849 0.260733133434588 1246 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1753 st043925 64 µM 0.639013750981133 0.254768742319536 no 850 0.261406993180021 1287 670181 SGTC_2748 diazoxide 86.69 µM 0.638904001641522 0.254803837783239 no 851 0.261442692308581 1255 3019 A potassium channel activatior. SGTC_790 1575-0012 79.1 µM 0.637419633805078 0.255278754975024 no 852 0.261925771414598 1309 378741 YLR208W SEC13 SGTC_1088 bifonazole 369 nM 0.636685803031219 0.255513711838049 no 853 0.262164761440671 1234 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_848 0368-0089 85.6 µM 0.636506620893892 0.255571099268518 no 854 0.262223133475117 1258 762535 SGTC_260 nsc-65238 3.989 µM 0.634933952035796 0.256075073373526 no 855 0.262735746195391 1236 3246252 SGTC_124 0136-0217 7.121 µM 0.633737736340981 0.256458756902087 no 856 0.263125996646224 1405 3976905 SGTC_193 1273-0060 1.558 µM 0.63330333067506 0.256598165653948 no 857 0.263267789347461 1180 2847393 YHR072W ERG7 SGTC_79 0052-0007 94.094 µM 0.633187628455326 0.256635303274777 no 858 0.263305561849062 1341 2801472 SGTC_1358 1509-0022 2.48 µM 0.632889829113812 0.256730902549714 no 859 0.263402795062739 1307 3258434 SGTC_1316 1272-0050 65.9 µM 0.632584132291744 0.256829056346854 no 860 0.263502625912794 1302 7340392 SGTC_346 4513-0042 7.16 µM 0.631201576305876 0.257273214203271 no 861 0.263954365716237 1305 2827372 SGTC_761 k216-0224 480 µM 0.628845128501579 0.25803116224374 no 862 0.264725226052878 1342 1340404 SGTC_2809 7964133 12.99 µM 0.628621092073881 0.258103283478928 no 863 0.264798574216308 1319 1253665 SGTC_366 0181-0206 4.31 µM 0.62838458759925 0.258179429736131 no 864 0.264876015551427 1332 274874 SGTC_2493 resveratrol 26.09 µM 0.627861864732906 0.258347769719073 no 865 0.265047217440445 1230 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3025 9087895 49.47 µM 0.626616781044743 0.258748970935016 no 866 0.265455232820364 1299 17173641 SGTC_3349 9149703 23.001 µM 0.626070033503885 0.258925250310979 no 867 0.265634503275682 1287 4910494 SGTC_1034 k072-0165 12.7 µM 0.624491037872762 0.259434690080023 no 868 0.266152577113816 1308 5835461 SGTC_1495 4469-0029 237 µM 0.623284681516188 0.259824251843503 no 869 0.266548731190867 1308 793680 SGTC_152 4469-0003 551.229 µM 0.622169874952843 0.260184518089434 no 870 0.266915086256062 1293 697280 SGTC_1017 4239-0030 168 µM 0.621358141399004 0.260447003697751 no 871 0.267182003419153 1278 1149593 SGTC_2848 9016370 25.97 µM 0.620472117266915 0.260733667814245 no 872 0.267473502786408 1332 7894410 SGTC_3044 9093193 49.47 µM 0.619250187912316 0.261129276842567 no 873 0.267875776940289 1269 25236277 SGTC_693 4161-2696 114 µM 0.618988841053296 0.261213929930179 no 874 0.267961855078297 1362 805759 SGTC_1572 epiandrosterone 68.9 µM 0.615530147313068 0.262335565089727 no 875 0.269102333112483 1265 441302 A steroid. SGTC_830 4076-0286 57.8 µM 0.615439713640429 0.262364925282793 no 876 0.269132185574013 1361 6866659 SGTC_1559 coumarin 343 70.1 µM 0.61526786287821 0.262420722982153 no 877 0.269188918671044 1363 108770 A hepatotoxic, DNA x-linker. SGTC_3097 9117246 49.47 µM 0.615198508337088 0.2624432432171 no 878 0.269211816386782 1323 16423892 SGTC_2220 6782180 200 µM 0.614039161333691 0.262819843279869 no 879 0.269594724663213 1273 833803 SGTC_2564 betulinic acid 100 µM 0.613999330418907 0.262832786786999 no 880 0.26960788483545 1403 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1310 1188-0297 994 nM 0.613825463088148 0.262889290763392 no 881 0.269665334536007 1270 1588352 SGTC_2958 9077254 16.72 µM 0.613002181333409 0.26315692788074 no 882 0.269937448695827 1333 16457351 SGTC_2162 5663267 200 µM 0.611845783696053 0.263533091150625 no 883 0.270319897512554 1316 6456493 SGTC_1721 st082152 9.2685 µM 0.610939055109482 0.263828231671092 no 884 0.270619964056254 1266 5296051 SGTC_3070 9117005 49.47 µM 0.610587657866209 0.263942656911835 no 885 0.270736297764409 1381 8779016 SGTC_1276 0871-0068 94.2 µM 0.610392083410396 0.264006352641469 no 886 0.270801055533529 1325 3414906 SGTC_2151 5563267 85.4165 µM 0.608473544012981 0.264631607813923 no 887 0.271436723675739 1322 5310824 SGTC_1878 temozolomide 1 mM 0.608001648805488 0.264785514581647 no 888 0.271593190173777 1310 5394 DNA alkylating agent. SGTC_3312 9133330 71.43 µM 0.607315723946176 0.265009307400983 no 889 0.271820702632854 1376 17617324 SGTC_3348 9149464 3.537 µM 0.606764057081662 0.265189366325193 no 890 0.272003752223309 1316 1951442 SGTC_2375 9072683 200 µM 0.606422413652821 0.26530090669831 no 891 0.272117144283691 1391 16798029 SGTC_102 gallobenzophenone 83.616 µM 0.606252000113326 0.265356552524111 no 892 0.272173713623003 1406 70837 SGTC_849 0386-0493 241 µM 0.603782709018375 0.26616352442207 no 893 0.272994058380939 1308 726119 SGTC_2369 9071472 200 µM 0.601600743097138 0.266877630185299 no 894 0.273719967067108 1385 17296037 SGTC_1077 5-fluorocytosine 377 nM 0.601430189978934 0.266933488940824 no 895 0.273776747843788 1336 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1883 5-benzylidenerhodanine 20 µM 0.600124485821035 0.267361322609303 no 896 0.274211637561029 1347 1273210 SGTC_3243 9134147 49.47 µM 0.599480404234141 0.267572492993561 no 897 0.274426286826998 1388 24282180 SGTC_1228 0124-0032 52.5 µM 0.599234545238495 0.267653123178348 no 898 0.274508244666046 1418 X1228 SGTC_555 4296-0685 37 µM 0.597144151824778 0.268339168218849 no 899 0.275205571115674 1337 2908540 YHR072W ERG7 SGTC_1058 3448-5425 97.3 µM 0.596660724831453 0.26849794968099 no 900 0.275366959777967 1266 7279705 SGTC_2718 lomofungin 53.02 µM 0.594340945093102 0.269260537240266 no 901 0.276142049055591 1399 5351222 A RNA synthesis inhibitor. SGTC_2006 4011487 200 µM 0.594110835308708 0.269336241041793 no 902 0.276218992124192 1420 45595294 SGTC_2217 6934799 96.0675 µM 0.593982039250234 0.269378618306049 no 903 0.276262062959489 1308 675606 SGTC_1733 st037357 54.9 µM 0.592881116501556 0.269740986978313 no 904 0.27663035819423 1283 1272339 YGL099W LSG1 SGTC_3110 9122132 49.47 µM 0.591130498610805 0.270317705066715 no 905 0.277216493131116 1432 918317 SGTC_1007 4101-0031 70 µM 0.590407526095123 0.270556058598161 no 906 0.277458733052765 1348 1146276 SGTC_559 1550-0661 158 µM 0.589304154270848 0.270920026524847 no 907 0.277828629296052 1398 5830875 SGTC_3108 9121785 49.47 µM 0.589007266418467 0.271018002259116 no 908 0.277928199573908 1345 17140271 SGTC_1256 0570-0116 285 µM 0.587474855226412 0.271523993003104 no 909 0.278442416569306 1340 410638 SGTC_1648 st011736 69.8 µM 0.587274277706653 0.271590257009962 no 910 0.278509756799308 1408 2855514 SGTC_426 0988-0037 14.6 µM 0.58537963627897 0.272216579252878 no 911 0.279146239091992 1364 5383008 SGTC_3328 9140624 29.0385 µM 0.584117504432811 0.272634207252489 no 912 0.279570629366015 1403 4904392 SGTC_856 0433-0016 11.3 µM 0.581732258977808 0.273424330753888 no 913 0.280373519524459 1361 3911780 SGTC_2079 5212404 121 µM 0.581531398376833 0.273490918468803 no 914 0.280441181530624 1409 758462 SGTC_1010 4112-3296 15.2 µM 0.581165603564773 0.273612204483159 no 915 0.280564423663063 1408 704384 SGTC_642 0335-0876 158 µM 0.579934108414145 0.274020724931585 no 916 0.280979526644312 1385 6812350 SGTC_1168 k815-0004 80.5 µM 0.57864637639547 0.274448222813719 no 917 0.281413902702919 1340 642433 SGTC_2288 7946289 167.31 µM 0.578380246600163 0.274536612904364 no 918 0.281503713641745 1464 1246052 SGTC_1117 retinoic acid 1.10837 µM 0.578300773199448 0.274563011248015 no 919 0.281530536246081 1448 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1962 st076595 64.5 µM 0.577981225035307 0.274669166849718 no 920 0.281638397527203 1379 279619 SGTC_1263 0774-1208 64.8 µM 0.576849716034003 0.275045222820353 no 921 0.282020490719851 1431 906585 SGTC_2411 st077133 39.94 µM 0.576609752068328 0.275125007205959 no 922 0.2821015549367 1515 1403142 YNL221C POP1 SGTC_1057 3448-5381 134 µM 0.575370898678468 0.275537088416686 no 923 0.282520240646207 1417 5497911 SGTC_754 3474-0146 171 µM 0.573891195072815 0.276029681384198 no 924 0.283020715855639 1302 24762078 SGTC_439 amiodarone 34.4 µM 0.570897725899827 0.277027526901921 no 925 0.284034486286412 1401 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_506 n9-isopropylolomoucine 153 µM 0.570402843193459 0.27719266143676 no 926 0.284202250812194 1418 6610355 SGTC_2284 7945075 39.21 µM 0.569913740305115 0.277355914639812 no 927 0.284368102525235 1443 1245402 SGTC_1292 0kpi-0043 232 µM 0.56936201300724 0.277540127084202 no 928 0.284555245276538 1353 3333905 SGTC_430 0958-0115 16.4 µM 0.56608195663036 0.278636515270201 no 929 0.285669034199989 1399 6833180 SGTC_1925 st057770 10.1 µM 0.564807279767158 0.279063155747894 no 930 0.286102427485964 1302 5989122 SGTC_2932 9016711 44.54 µM 0.563585880043904 0.279472261910619 no 931 0.286517999254806 1447 7117328 SGTC_1624 st003710 6.25 µM 0.562938950499425 0.279689068000707 no 932 0.28673822795958 1470 24207033 SGTC_2822 7994718 71.43 µM 0.562552591346416 0.279818587814707 no 933 0.286869791172966 1406 1018011 SGTC_2512 diallyl trisulfide 49.23 µM 0.561915948621733 0.280032074052098 no 934 0.287086643455161 1356 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_213 1246-0773 967 nM 0.561710442426219 0.280101003566256 no 935 0.287156659232991 1402 6251622 SGTC_1480 1070-0044 41.2 µM 0.560366781712422 0.280551887790216 no 936 0.287614642339121 1420 3124987 SGTC_281 1672-3440 14.9 µM 0.559672728366357 0.280784924628274 no 937 0.287851343687974 1406 6833000 SGTC_252 miconazole 1.30953 nM 0.559280879407803 0.280916534001939 no 938 0.287985021266623 1375 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1848 st056003 16.4 µM 0.558207193330348 0.281277303084828 no 939 0.288351454717297 1428 146492 SGTC_611 3453-1652 23.7 µM 0.557726765119687 0.281438804094246 no 940 0.288515489041029 1441 1560575 SGTC_1892 st058411 7.36 µM 0.557635526965038 0.281469479816898 no 941 0.288546645778349 1461 3934738 SGTC_942 3253-1115 227 µM 0.557359461116691 0.281562307381669 no 942 0.288640928614036 1483 46497897 SGTC_3260 9137109 49.47 µM 0.556975484975507 0.281691444494707 no 943 0.288772089418363 1361 17478346 SGTC_2831 7999036 19.48 µM 0.555983017404231 0.28202535891071 no 944 0.289111232198215 1551 2988270 SGTC_2959 9079155 11 µM 0.553881148991182 0.282733158480971 no 945 0.289830093532196 1402 16189457 SGTC_2435 5706476 10.6 µM 0.553737582950504 0.282781535152326 no 946 0.289879225220146 1443 5725375 SGTC_645 0845-0943 5.41 µM 0.553223494773218 0.282954797267607 no 947 0.290055190360208 1398 1885106 SGTC_826 1683-5028 118 µM 0.55317238317432 0.282972026093302 no 948 0.290072687876463 1423 722377 SGTC_3057 9095946 49.47 µM 0.55248880122076 0.283202498007279 no 949 0.290306752482919 1433 24540043 SGTC_656 4090-1979 187 µM 0.551519977375557 0.283529294339002 no 950 0.290638637913839 1470 22330961 SGTC_3185 9108267 49.47 µM 0.551332551260658 0.283592536353642 no 951 0.290702864081085 1360 4910486 SGTC_2969 9091408 28.7 µM 0.550789968452501 0.283775654748988 no 952 0.290888830835443 1368 4286311 SGTC_1675 st018485 24.5 µM 0.550183317696166 0.283980462700692 no 953 0.291096822280484 1429 3323024 SGTC_3230 9131665 49.47 µM 0.548195241025257 0.284652141321296 no 954 0.291778924734797 1388 15943720 SGTC_2004 4023728 41.89 µM 0.548009189699756 0.284715038199547 no 955 0.291842796411929 1416 360084 YDR527W RBA50 SGTC_2497 7-hydroxyflavone 100 µM 0.546892147001307 0.285092807267325 no 956 0.29222641559033 1442 5281894 SGTC_317 4495-0002 170 µM 0.546500881083118 0.285225184709114 no 957 0.292360841118203 1383 15991618 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.545384716618145 0.285602978765222 no 958 0.292744474807308 1470 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_886 0866-0150 153 µM 0.544289624481671 0.285973871641328 no 959 0.29312109281895 1521 271463 SGTC_2216 7189485 200 µM 0.543587361803687 0.286211838914723 no 960 0.293362729294438 1438 731273 SGTC_2638 epoxomicin 18 µM 0.542198033432616 0.286682900711731 no 961 0.293841044955143 1481 9915668 A protesome inhibitor. SGTC_568 1193-0097 7.48 µM 0.540725918577445 0.287182432634658 no 962 0.294348255498406 1350 3646150 SGTC_1755 st041960 45.185 µM 0.540637301682629 0.28721251609988 no 963 0.294378800946949 1435 2257073 SGTC_1492 4158-0558 28.5 µM 0.539161194066147 0.28771384102923 no 964 0.294887817082704 1511 3967268 SGTC_1882 5615643 20 µM 0.537732020523937 0.288199619522288 no 965 0.295381034776221 1366 2253075 SGTC_340 k038-0059 454 µM 0.537692483512505 0.288213063717104 no 966 0.295394684666252 1462 23733424 SGTC_1608 st001473 40.5 µM 0.537571140286933 0.288254327205078 no 967 0.295436579419106 1382 7292267 SGTC_2338 7999974 200 µM 0.537564344639087 0.28825663818807 no 968 0.29543892575358 1481 315925 SGTC_2469 5655019 90.81 µM 0.537477609865418 0.288286134684482 no 969 0.295468873436297 1529 2788239 SGTC_140 0062-0056 502.533 µM 0.536891132235883 0.288485619544489 no 970 0.295671408384911 1348 3758964 SGTC_200 k038-0079 37.545 µM 0.536616807034858 0.288578951011766 no 971 0.295766166105107 1447 3436683 SGTC_1553 gossypol 38.6 µM 0.536192623031287 0.288723295737934 no 972 0.295912715682593 1372 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2381 9035592 200 µM 0.535290426292773 0.289030415463395 no 973 0.296224522731004 1367 4749657 SGTC_219 mitoxanthrone 164.414 µM 0.53441171301752 0.289329688748998 no 974 0.296528358481414 1462 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_573 3702-0553 84.7 µM 0.533773762122677 0.289547054070276 no 975 0.296749034410604 1418 1222756 SGTC_1676 st018489 23.4 µM 0.533503388305091 0.289639200108303 no 976 0.29684258308767 1458 3696235 SGTC_2094 5332512 191.667 µM 0.53332243043915 0.289700880005138 no 977 0.2969052016038 1536 755774 SGTC_544 k015-0020 52.4 µM 0.532126571645422 0.2901086460649 no 978 0.297319167497974 1441 3008304 SGTC_3021 9087658 49.47 µM 0.531182712601677 0.290430674610765 no 979 0.297646085685274 1424 25237042 SGTC_3191 9110352 49.47 µM 0.530578365166663 0.290636955444457 no 980 0.297855495598555 1470 17122424 SGTC_2935 9038016 29.96 µM 0.53004682721453 0.290818440977148 no 981 0.298039732112568 1422 6463195 SGTC_1877 wortmannin 25 µM 0.528909121523657 0.291207071202362 no 982 0.298434247019681 1442 312145 A covalent inhibitor of PI 3-kinase. SGTC_1367 1812-0510 76.9 µM 0.528739278773523 0.291265108780946 no 983 0.29849316268137 1452 1142582 YDR527W RBA50 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.526651439141999 0.291978992713955 no 984 0.299217831885843 1345 641818 YHR062C RPP1 SGTC_2265 7929201 200 µM 0.525394876946673 0.292409034701913 no 985 0.299654357080108 1390 1265108 SGTC_979 1426-2828 121 µM 0.523096100917473 0.293196521946236 no 986 0.300453689368654 1517 747872 SGTC_2675 theaflavin digallate 100 µM 0.522933542722647 0.293252246397083 no 987 0.300510250683811 1456 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2916 7875993 68.79 µM 0.522516504509779 0.293395228266716 no 988 0.300655379043716 1551 1299250 SGTC_2078 5212016 200 µM 0.520322008862166 0.294148144395074 no 989 0.301419579265997 1452 1899708 SGTC_227 fluconazole 33.516 µM 0.520211238872182 0.294186172464309 no 990 0.301458176425107 1404 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_518 1021-0119 62.6 µM 0.518938549568348 0.294623257991786 no 991 0.301901797110368 1412 1097762 SGTC_810 3825-7150 143 µM 0.517937721528723 0.294967187235889 no 992 0.302250861136749 1583 22330411 YGL099W LSG1 SGTC_1687 st020778 55.3625 µM 0.517667276019681 0.295060156137258 no 993 0.3023452169028 1475 4259299 SGTC_1636 st007707 68.9 µM 0.517529051096647 0.295107677830834 no 994 0.302393447314593 1533 403051 SGTC_53 0973-0023 39.979 µM 0.51721098597551 0.295217041923635 no 995 0.302504441935622 1454 674768 SGTC_1798 st045719 60.953 µM 0.516208501474491 0.295561860039595 no 996 0.302854396613808 1394 3980186 SGTC_2918 7977171 22.06 µM 0.512625332007443 0.296795850818807 no 997 0.304106714854227 1428 2236483 SGTC_2067 5224629 34.075 µM 0.512559479597419 0.296818551472779 no 998 0.304129751863133 1431 2835000 SGTC_2736 butenafine 14.65 µM 0.511962143604247 0.297024501526989 no 999 0.304338752154067 1498 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3126 9127922 49.47 µM 0.51112089423332 0.297314659047748 no 1000 0.304633203039191 1480 45595682 SGTC_357 1325-0123 420 µM 0.510706257580887 0.297457720090845 no 1001 0.304778379172959 1502 1098503 SGTC_807 1315-0151 48 µM 0.509905867447916 0.297733965559384 no 1002 0.305058705557488 1573 4011080 SGTC_2917 7979103 53.79 µM 0.509008628094836 0.298043776487295 no 1003 0.305373088172132 1555 2980565 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.508347549606495 0.298272136552945 no 1004 0.305604814563672 1496 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1041 0206-0046 107 µM 0.507083082218023 0.298709150416833 no 1005 0.306048262442318 1493 50494 SGTC_3045 9092950 49.47 µM 0.506663542992882 0.298854212080049 no 1006 0.30619545743813 1588 44120432 SGTC_2897 9048598 12.99 µM 0.506519206185042 0.29890412598657 no 1007 0.306246105125346 1440 6467404 SGTC_3267 9137951 49.47 µM 0.506253069475687 0.298996170115648 no 1008 0.306339502022722 1507 16643986 SGTC_933 2914-0560 114 µM 0.505150561751203 0.299377612547284 no 1009 0.30672654544135 1612 463887 SGTC_2134 5324836 1.464 µM 0.505009088297133 0.299426575095196 no 1010 0.306776226350973 1526 699272 SGTC_134 0269-0018 6.916 µM 0.504177051245606 0.299714608239871 no 1011 0.307068482703045 1417 4378915 SGTC_3107 9121808 49.47 µM 0.503441504631426 0.299969342952868 no 1012 0.307326948525744 1466 662681 SGTC_1745 st081495 74 µM 0.502778423949911 0.300199065177117 no 1013 0.307560032387239 1476 13842402 YBL026W LSM2 SGTC_307 1501-1223 22.3 µM 0.501920315904099 0.300496472037066 no 1014 0.307861786961268 1460 2830329 SGTC_1326 1431-2094 10.8 µM 0.498881324372512 0.30155080758606 no 1015 0.308931495711413 1448 616278 SGTC_2092 5303694 80.6725 µM 0.49805882011889 0.30183644983882 no 1016 0.309221292194267 1442 1963699 SGTC_487 nimodipine 119 µM 0.493414898682133 0.303451483903581 no 1017 0.310859728670108 1506 4497 L-type voltage-gated calcium channels inhibitor SGTC_1489 4065-0444 182 µM 0.493068147387106 0.30357222965343 no 1018 0.310982218212355 1570 2877968 SGTC_716 1683-5115 658 µM 0.491849234485657 0.303996849703073 no 1019 0.311412964094173 1497 723597 SGTC_570 0987-0065 62.6 µM 0.49147290318892 0.304128001810864 no 1020 0.311546006247831 1445 3104428 SGTC_1797 st048695 56.8 µM 0.491056108213321 0.30427328499835 no 1021 0.311693382003988 1560 592262 YIL048W NEO1 SGTC_3129 9127257 49.47 µM 0.490662519058584 0.304410507647367 no 1022 0.311832580040152 1384 837894 SGTC_2305 7443522 69.23 µM 0.490537578745696 0.304454073145397 no 1023 0.311876772464903 1541 5415886 SGTC_2121 5257820 149.641 µM 0.489693152166938 0.30474858937933 no 1024 0.31217552413708 1543 791256 SGTC_606 k015-0008 38.6 µM 0.489468147312559 0.304827087173742 no 1025 0.312255149990823 1612 1970475 SGTC_3019 9081971 49.47 µM 0.488628939820204 0.305119942026401 no 1026 0.312552210303301 1605 16451803 SGTC_103 0844-0104 51.839 µM 0.487417407979771 0.305542945565404 no 1027 0.312981279812886 1532 5375804 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.486841238711299 0.305744204889117 no 1028 0.313185421736065 1535 688801 SGTC_2389 9091542 195.52 µM 0.486701771643843 0.305792930383101 no 1029 0.313234844776195 1490 3626624 YOL127W RPL25 SGTC_177 1327-0068 8.361 µM 0.486012870987909 0.306033661457603 no 1030 0.313479020172519 1469 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2644 guaiazulene 100 µM 0.482266782686538 0.307344168100996 no 1031 0.31480822050693 1534 3515 A coloring agent. SGTC_3008 9078912 71.4286 µM 0.482165923286412 0.307379486214005 no 1032 0.314844041088413 1488 16648731 SGTC_809 3998-0021 90 µM 0.481953867226229 0.307453748081811 no 1033 0.314919359247977 1505 715485 SGTC_2383 9036125 200 µM 0.481393993093546 0.30764985349387 no 1034 0.315118252560834 1538 79580 SGTC_2396 5342950 42.78 µM 0.479864173785589 0.308185978868457 no 1035 0.315661988727747 1502 1886677 SGTC_1562 morin hydrate 59.1 µM 0.479500124310422 0.308313620413772 no 1036 0.315791439899726 1530 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2690 usnic acid 100 µM 0.477797504283519 0.308910893620587 no 1037 0.316397168823743 1655 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.477053975970721 0.309171879496841 no 1038 0.316661843285849 1555 756377 SGTC_1590 st077108 57.8 µM 0.475801445681377 0.309611747934657 no 1039 0.317107919914428 1544 5489485 SGTC_1249 0481-0015 10.2 µM 0.475081764560777 0.30986461180423 no 1040 0.317364347758661 1473 4227577 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.474503092745998 0.310067996559876 no 1041 0.317570596522946 1558 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2757 clomiphene 4.22 µM 0.474427201947823 0.310094674076586 no 1042 0.317597649534162 1660 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2228 7354201 200 µM 0.474130171961831 0.310199097169392 no 1043 0.317703542033694 1588 753451 SGTC_291 SEC14.278 35.5 µM 0.473932678098787 0.310268536072865 no 1044 0.317773957721763 1605 1068044 SGTC_2491 paeonol 100 µM 0.473464064658744 0.310433327768744 no 1045 0.31794106643751 1485 11092 Increases levels of cortical cytochrome oxidase. SGTC_311 1315-0136 58 µM 0.47329441547387 0.310492995657581 no 1046 0.318001572901363 1591 6759207 SGTC_973 1325-0077 65.9 µM 0.473087114503896 0.310565912952793 no 1047 0.318075514709985 1637 2835149 SGTC_710 3448-4187 58 µM 0.472984859051317 0.310601883644854 no 1048 0.318111990693696 1531 3946412 SGTC_1656 st012921 11 µM 0.472097206313331 0.310914211837597 no 1049 0.318428703228819 1553 6732821 SGTC_2256 7954252 200 µM 0.471618617567469 0.31108266392862 no 1050 0.318599517729327 1490 2972920 SGTC_2394 5221648 200 µM 0.471400284476924 0.311159525241366 no 1051 0.318677456437022 1672 788586 SGTC_1511 0906-3109 28.5 µM 0.470887048155598 0.311340235814061 no 1052 0.318860698803863 1522 2882180 SGTC_2812 7970281 58.44 µM 0.470766082149805 0.311382834582989 no 1053 0.31890389412582 1626 2233435 SGTC_280 3448-3607 3.04 µM 0.470573688752922 0.31145059205874 no 1054 0.318972600268819 1539 626179 SGTC_248 streptozotocin 5.23457 mM 0.470418700600225 0.311505180728908 no 1055 0.319027953044804 1609 5300 DNA alkylating agent. SGTC_2651 TUB2.036 5 µM 0.469986833902491 0.311657311172005 no 1056 0.319182212060572 1591 15992207 YFL037W TUB2 SGTC_1215 3852-0577 11.2 µM 0.469439336705421 0.311850220119744 no 1057 0.319377818290605 1637 2884876 SGTC_3344 9148862 3.898 µM 0.468971189335574 0.312015211351829 no 1058 0.319545114811043 1605 4905352 SGTC_2746 daunorubicin 9.88 µM 0.468912830725062 0.312035781577948 no 1059 0.319565972341932 1536 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1315 1237-0019 3.69 µM 0.468629532486195 0.312135646787335 no 1060 0.319667232035886 1597 825140 SGTC_65 0798-0905 34.986 µM 0.468516154033335 0.312175617593464 no 1061 0.319707760825443 1722 3602145 SGTC_1335 1486-0900 202 µM 0.466506483622501 0.312884479869808 no 1062 0.320426503881967 1508 X1335 SGTC_128 0906-2981 13.371 µM 0.46471164522269 0.313518150881338 no 1063 0.321068983909119 1596 6740226 SGTC_2210 7115885 190.385 µM 0.463502072595743 0.313945503513274 no 1064 0.321502264791177 1523 2927039 SGTC_1118 chelidonine 707.474 nM 0.463103295435928 0.31408644973844 no 1065 0.321645163998415 1658 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2610 ononetin 44.17 µM 0.452553940664612 0.317824874356889 no 1066 0.325434985720275 1512 259632 SGTC_1868 st057644 42.7 µM 0.452453430566416 0.317860582854704 no 1067 0.325471181403932 1522 688665 SGTC_1844 rapamycin 4 nM 0.452015327014229 0.318016248882003 no 1068 0.325628970419587 1546 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3120 9124077 49.47 µM 0.451592075734896 0.318166668172993 no 1069 0.325781439864114 1560 18774327 YGL155W CDC43 SGTC_770 0389-1121 67.2 µM 0.450952011622769 0.318394197556152 no 1070 0.326012067990543 1662 6753108 SGTC_1037 k284-1091 78.7 µM 0.450279517557394 0.318633328925101 no 1071 0.326254453010843 1529 3334711 SGTC_1513 0337-0559 19 µM 0.449953233952333 0.318749378954582 no 1072 0.326372080886438 1489 775073 SGTC_3314 9135860 59.4275 µM 0.447997152759176 0.319445475201631 no 1073 0.327077625733405 1588 25252478 SGTC_565 1418-0001 44.5 µM 0.447746346089078 0.319534774036416 no 1074 0.3271681347355 1610 2862145 SGTC_902 1120-0002 2.07 µM 0.44728712664211 0.319698304630069 no 1075 0.327333880328236 1502 3280475 SGTC_1209 2323-2347 50.3 µM 0.446878698674428 0.319843777553937 no 1076 0.327481322414162 1584 5412760 SGTC_2884 9058502 51.95 µM 0.446597495898006 0.319943951815266 no 1077 0.327582851978846 1525 6471554 SGTC_1529 apigenin 74 µM 0.446252062741116 0.320067025155971 no 1078 0.327707589672007 1644 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2646 retinol 96.75 µM 0.446190434640639 0.320088984528611 no 1079 0.327729845918454 1577 445354 A vitamin A analog and teratogen. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.445428440675527 0.320360550863643 no 1080 0.328005081407741 1584 17037758 SGTC_1546 5-methoxyflavanone 78.7 µM 0.444277142460163 0.320771043485217 no 1081 0.328421112453617 1636 147795 SGTC_1816 st051957 91.6 µM 0.444196637060217 0.320799755699621 no 1082 0.32845021170714 1568 674121 SGTC_2747 doxorubicin 7.63 µM 0.4419768007045 0.321591881108652 no 1083 0.329252996874059 1562 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1621 st003705 32.4 µM 0.441601195925574 0.321725992150462 no 1084 0.329388909221419 1666 24207032 SGTC_669 0108-0021 26.2 µM 0.439533053400635 0.322464845636279 no 1085 0.330137668678598 1835 17201 SGTC_1420 4'-methoxyflavone 42 µM 0.437650465076105 0.32313801933102 no 1086 0.330819841383792 1654 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2705 st078069 42.8 µM 0.436750211617754 0.323460135899505 no 1087 0.331146255123084 1546 1530061 SGTC_2735 sertaconazole 140 nM 0.436469084251356 0.323560752237643 no 1088 0.331248212545581 1638 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3200 9114385 49.47 µM 0.434571940785068 0.324240082622625 no 1089 0.33193658281945 1529 17018030 YLR208W SEC13 SGTC_237 nikkomycin 200 µM 0.432318107971188 0.325047897507036 no 1090 0.332755114023133 1653 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1187 1391-0724 117 µM 0.431344228955674 0.325397208462864 no 1091 0.333109047662977 1601 6997986 SGTC_620 0109-0052 432 µM 0.430016106070184 0.325873826898096 no 1092 0.333591962618968 1668 493037 SGTC_2475 5812728 15.03 µM 0.429038013552274 0.326225013349875 no 1093 0.333947780472092 1537 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_316 k060-0003 58.6 µM 0.428738149508626 0.326332711137635 no 1094 0.33405689719423 1642 6152314 SGTC_1338 1486-1223 76 µM 0.428453315919003 0.32643502406798 no 1095 0.334160557517018 1649 3444526 SGTC_751 0833-0568 350 µM 0.428106843463459 0.326559495435658 no 1096 0.334286667306352 1624 6954252 SGTC_431 k089-0097 107 µM 0.42657257282994 0.327110919144072 no 1097 0.334845339096547 1537 5499420 SGTC_2788 5282734 71.43 µM 0.425818452377229 0.327382091896798 no 1098 0.335120070044255 1719 743706 SGTC_1060 3448-7350 82 µM 0.42322258946523 0.328316229238463 no 1099 0.336066433472897 1702 570178 SGTC_1618 st003135 44.5 µM 0.422307543839643 0.328645770504233 no 1100 0.336400276270197 1589 1270615 SGTC_2109 5483026 200 µM 0.422149805664868 0.328702591244848 no 1101 0.336457838088768 1616 759335 SGTC_1014 4130-3005 69.3 µM 0.421587228419404 0.328905276116177 no 1102 0.336663164996946 1570 743608 SGTC_1950 st077106 7.18 µM 0.419658093930105 0.329600684968508 no 1103 0.337367621337936 1565 13831864 SGTC_2802 7925815 54.55 µM 0.41916623416502 0.329778083586706 no 1104 0.337547323679185 1573 1262923 SGTC_71 0417-1750 47.813 µM 0.418918588830674 0.329867416104632 no 1105 0.337637815621588 1733 6811472 SGTC_1498 4478-3555 97.6 µM 0.415551939237795 0.331082820590684 no 1106 0.338868950621079 1651 3437919 SGTC_196 k015-0023 18.111 µM 0.415008430851991 0.331279201619486 no 1107 0.33906786565658 1592 5211998 SGTC_2040 5100729 123 µM 0.412128073181729 0.332320709101685 no 1108 0.340122776556381 1642 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_910 3454-3003 490 µM 0.410560529360747 0.332888061925217 no 1109 0.340697405514757 1649 820824 SGTC_333 3486-0131 40.1 µM 0.409609845141793 0.333232336735746 no 1110 0.341046086862323 1726 6744690 SGTC_3186 9110464 49.47 µM 0.408849663367081 0.333507725341528 no 1111 0.341324995574784 1661 17018021 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.408471204461135 0.333644861903913 no 1112 0.341463883495608 1622 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2259 7964009 200 µM 0.406746550184377 0.334270080622817 no 1113 0.342097073634935 1665 313134 SGTC_2186 6124449 200 µM 0.40361167360484 0.335407707973292 no 1114 0.343249150027338 1665 3834182 YLR033W RSC58 SGTC_1658 st012944 20 µM 0.402674271871255 0.335748179184522 no 1115 0.34359393165135 1680 24207260 SGTC_755 1995-0008 37.3 µM 0.400067973789359 0.336695513904551 no 1116 0.344553226013062 1610 689533 SGTC_2869 9037858 32.47 µM 0.398747374879351 0.337175920250987 no 1117 0.345039678285531 1570 27187042 SGTC_63 0099-0242 26.702 µM 0.396462613069266 0.338007695957999 no 1118 0.345881891726781 1659 3898502 YLR359W ADE13 SGTC_1391 3442-0225 151 µM 0.395434042909049 0.33838240922381 no 1119 0.346261294669317 1647 5227075 SGTC_43 0570-0105 72.5 µM 0.394875885689731 0.338585815734849 no 1120 0.346467243637469 1659 1114046 YDL195W SEC31 SGTC_1786 berberine 21.6 µM 0.394672833889102 0.338659824597296 no 1121 0.34654217699781 1569 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3086 9117350 49.47 µM 0.393103456212016 0.339232045543317 no 1122 0.347121535743155 1586 2679265 SGTC_805 3852-0218 479 µM 0.392489213323127 0.339456109707201 no 1123 0.347348389917579 1593 6615355 SGTC_866 0495-0101 262 µM 0.392004410491471 0.339632996678884 no 1124 0.347527477496409 1577 635694 SGTC_1438 4092-1045 4 µM 0.390572196223882 0.340155765944199 no 1125 0.34805674029423 1613 1351342 SGTC_2566 crystal violet carbinol 226 nM 0.389920999366008 0.340393559552236 no 1126 0.348297482635405 1541 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1003 4049-0218 100 µM 0.389741425320648 0.340459144686598 no 1127 0.348363880500942 1689 295161 SGTC_875 0709-0210 25.7 µM 0.388643044890328 0.340860406878667 no 1128 0.348770109957531 1705 6251364 SGTC_468 gf-109203x 121 µM 0.388571245033467 0.340886643199945 no 1129 0.348796670750835 1717 2396 A protein kinase C inhibitor. SGTC_1829 berberine 14.4 µM 0.388278542782847 0.340993607228958 no 1130 0.348904957240548 1750 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2805 7950783 58.44 µM 0.387120244684999 0.341417016705905 no 1131 0.349333595377379 1677 1178958 YDL195W SEC31 SGTC_3176 9106582 49.47 µM 0.386238549864447 0.341739449264025 no 1132 0.349660002990979 1659 17018027 SGTC_2386 9075165 157.42 µM 0.384935449248921 0.34221619981103 no 1133 0.350142620547689 1666 16452277 SGTC_1227 3909-8010 46.6 µM 0.384290498218695 0.342452253810872 no 1134 0.350381574836642 1657 15982272 SGTC_1016 4226-1401 38 µM 0.382232043499963 0.343206065732727 no 1135 0.351144627888179 1622 2901613 SGTC_2716 st080858 38.6235 µM 0.3821750686016 0.343226938993721 no 1136 0.351165756591833 1728 5296050 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.381982360522489 0.34329754285769 no 1137 0.351237224312875 1661 5379071 SGTC_3024 9090631 49.47 µM 0.377406139437074 0.344975768611062 no 1138 0.352935902523232 1785 25236383 SGTC_1490 4089-0339 670 nM 0.376004279748697 0.345490481646383 no 1139 0.353456857161883 1767 742542 SGTC_1376 2910-0861 41.3 µM 0.37468478703119 0.345975213625125 no 1140 0.35394745380132 1689 1112859 SGTC_1144 3486-0183 12.5 µM 0.374310847311512 0.346112630965367 no 1141 0.354086531361072 1672 6744069 SGTC_1325 1431-0015 227 µM 0.373955345004854 0.346243291620283 no 1142 0.354218769636627 1591 1103340 SGTC_496 calpeptin 138 µM 0.372659396403518 0.346719757027457 no 1143 0.354700979985219 1619 73364 A calpain inhibitor. SGTC_2245 6637752 200 µM 0.372439911434045 0.346800476391471 no 1144 0.354782671374072 1800 681890 SGTC_604 1000-0114 314 µM 0.371687963854071 0.347077070722605 no 1145 0.355062593732584 1766 1572745 SGTC_2260 7964312 200 µM 0.371166563284961 0.34726890912753 no 1146 0.355256737886387 1778 231951 SGTC_1849 st056239 19.2 µM 0.371103466218713 0.347292127025435 no 1147 0.355280234707539 1562 5393181 SGTC_719 2810-4230 27.3 µM 0.370879847703952 0.347374416793979 no 1148 0.355363512806846 1686 721079 SGTC_2444 5485484 36.41 µM 0.366806241991549 0.348874725914355 no 1149 0.356881775635277 1736 6790631 SGTC_1483 3453-0561 55.9 µM 0.366761985948464 0.3488910384496 no 1150 0.356898282694195 1724 4546991 SGTC_1009 4106-0057 9.87 µM 0.36636478500865 0.349037457041104 no 1151 0.35704644663985 1786 2928005 SGTC_1255 0566-0045 221 µM 0.366039454172685 0.349157399190549 no 1152 0.357167817654148 1730 2788469 SGTC_2037 5169046 200 µM 0.36393903415338 0.349932138971622 no 1153 0.357951767735194 1717 5718022 SGTC_1872 amphotericin b 148 nM 0.362759792732519 0.350367376331727 no 1154 0.358392164767167 1761 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_410 α-linolenic acid 100 µM 0.361657994123203 0.350774208545931 no 1155 0.358803810457507 1768 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.359618739007671 0.351527641986866 no 1156 0.359566134090742 1774 688662 SGTC_2794 7785382 27.27 µM 0.359312589924607 0.351640803826831 no 1157 0.359680628485108 1846 2205081 SGTC_2636 apigenin dimethyl ether 100 µM 0.356855343399653 0.352549550990188 no 1158 0.360600051106075 1718 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2855 9016525 58.44 µM 0.356752717051434 0.352587522967964 no 1159 0.360638468165371 1659 43811474 SGTC_2457 5731572 11.68 µM 0.355123409869126 0.353190566817982 no 1160 0.361248569813526 1809 2865357 SGTC_2715 st079500 56.4 µM 0.354512434867289 0.35341679781225 no 1161 0.361477443352392 1642 28246688 SGTC_318 1488-0629 67.2 µM 0.352973448441739 0.353986881026163 no 1162 0.36205417302953 1665 3662576 SGTC_294 k038-0071 157 µM 0.352250948189301 0.354254628177876 no 1163 0.362325035590172 1709 24152826 SGTC_172 1112-0046 2.638 µM 0.35197985006624 0.354355111448336 no 1164 0.362426687026491 1705 2802135 YIL048W NEO1 SGTC_204 PMA1.184 62.41 µM 0.351605266840571 0.354493968441702 no 1165 0.36256715738138 1717 2252213 YGL008C PMA1 SGTC_265 mycophenolic acid 32.932 µM 0.351591523472994 0.354499063439004 no 1166 0.36257231155656 1792 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_446 go6976 132 µM 0.349156355786566 0.355402248987878 no 1167 0.363485964876326 1812 3501 A protein kinase C inhibitor. SGTC_3067 9117431 49.47 µM 0.347693096517408 0.355945352190956 no 1168 0.36403534088051 1693 17150885 SGTC_986 1493-0483 84 µM 0.347640830556301 0.355964756637418 no 1169 0.364054969145679 1797 40079 SGTC_1079 idarubicin 2.36 µM 0.345878941161784 0.356619099955894 no 1170 0.364716847759038 1782 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_929 2805-0021 398 µM 0.345425146337104 0.356787702038562 no 1171 0.364887387603186 1723 3098024 SGTC_3188 9110789 49.47 µM 0.343075161490966 0.357661258010848 no 1172 0.365770958327218 1793 849217 SGTC_3172 9105863 49.47 µM 0.342166338087105 0.35799929376297 no 1173 0.366112858139448 1743 2348785 SGTC_2997 9067075 71.4286 µM 0.341925381123826 0.358088936098757 no 1174 0.366203524111967 1769 27209819 SGTC_2233 sulbentine 40.3845 µM 0.341417809096791 0.358277791854287 no 1175 0.366394534983204 1711 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1795 st049545 62.3 µM 0.341319554930515 0.358314353953501 no 1176 0.366431514081149 1846 5291882 SGTC_670 4204-0025 119 µM 0.340688194097409 0.358549325378502 no 1177 0.366669163646301 1794 719039 SGTC_2224 6650123 117.647 µM 0.339838622049623 0.358865592244911 no 1178 0.366989030426193 1725 2908370 SGTC_2722 naftopidil 47.16 µM 0.338597533349698 0.359327781396071 no 1179 0.367456470527554 1785 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1837 st055472 66.5 µM 0.338081914857372 0.35951986151417 no 1180 0.367650729408741 1773 676091 SGTC_2219 9098279 200 µM 0.336194101802258 0.360223419242299 no 1181 0.36836225020171 1824 902349 SGTC_3249 9135183 49.47 µM 0.335958411230494 0.360311290655125 no 1182 0.3684511142494 1767 4902779 SGTC_1905 st060207 84.5 µM 0.335414672737868 0.360514038275457 no 1183 0.368656150572198 1722 1948547 SGTC_1855 st056195 39.6 µM 0.33477373094444 0.360753081142654 no 1184 0.368897888944817 1831 4028379 SGTC_495 decylubiquinone 155 µM 0.330541636171328 0.362332826710608 no 1185 0.370495368844122 1705 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1412 3909-8563 178 µM 0.328422875490251 0.363124595809559 no 1186 0.371295974598354 1845 23767530 SGTC_3343 9148379 18.9835 µM 0.327087496650881 0.363623920402835 no 1187 0.371800854193233 1860 1955036 SGTC_2299 7976368 114.88 µM 0.326792373469984 0.363734304101474 no 1188 0.371912464057388 1840 2979718 SGTC_1955 wogonin 32.4 µM 0.325786619063122 0.364110567156065 no 1189 0.372292901670637 1836 5281703 A flavanone. SGTC_2487 5918373 44.05 µM 0.324504960685455 0.364590238562555 no 1190 0.372777883603853 1857 2876279 SGTC_987 1497-1013 404 µM 0.320316655875616 0.366159222247057 no 1191 0.374364149116256 1771 1676435 SGTC_2017 5132927 60.65 µM 0.318632016209633 0.366790939563179 no 1192 0.375002786236902 1674 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2976 9009005 19.48 µM 0.317156040122823 0.367344707566792 no 1193 0.375562602082391 1899 2993148 SGTC_1188 1403-0014 4.57 µM 0.315338325428722 0.368027070866127 no 1194 0.37625239437776 1753 9614867 SGTC_2642 cholecalciferol 100 µM 0.314829490933516 0.368218160163948 no 1195 0.376445559490461 1818 9821465 A vitamin D precursor, similar to steriods. SGTC_191 3914-0123 66.505 µM 0.313044343289882 0.368888817675266 no 1196 0.377123486453123 1726 3144412 SGTC_1934 st074720 32.6 µM 0.312964343169605 0.36891888207991 no 1197 0.377153876153428 1668 17250992 SGTC_3164 9100705 49.47 µM 0.312015018753191 0.369275703644843 no 1198 0.377514554705273 1847 17174235 SGTC_1804 st050076 49.1 µM 0.310676922994558 0.369778843530419 no 1199 0.378023121238591 1812 3895976 SGTC_3154 9100113 49.47 µM 0.309698627247331 0.370146835526118 no 1200 0.378395073392392 1716 25237525 SGTC_2586 curcumin 80 µM 0.307893691423879 0.370826085131906 no 1201 0.37908161314192 1847 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1454 4239-0054 42.6 µM 0.306320764836722 0.371418351469516 no 1202 0.379680215287668 1870 1340767 SGTC_3035 9091303 49.47 µM 0.304341175804281 0.372164174340672 no 1203 0.380433989116152 1778 25237002 SGTC_2960 9079389 5.97 µM 0.30418390809529 0.372223446569208 no 1204 0.380493891908729 1898 16457355 SGTC_2923 7992654 58.14 µM 0.304091260781588 0.372258365597749 no 1205 0.380529182330515 1756 2985126 SGTC_1206 3978-0017 132 µM 0.30355003036874 0.372462377818384 no 1206 0.380735363047948 1846 3873677 SGTC_3036 9090181 49.47 µM 0.302602474900908 0.372819636982295 no 1207 0.381096414076566 1783 25236586 SGTC_1362 1611-0397 101 µM 0.301113479971501 0.373381257362725 no 1208 0.381663981125837 1743 27816 SGTC_1938 st074717 56.4 µM 0.301013606178927 0.373418937487648 no 1209 0.381702059600484 1743 17250979 SGTC_2648 atorvastatin 78.68 µM 0.299387468922188 0.374032612370437 no 1210 0.382322211151602 1862 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2359 9039622 200 µM 0.298099925240235 0.374518734792067 no 1211 0.382813449313662 1845 6463596 SGTC_3174 9107204 49.47 µM 0.295595064814566 0.37546503592398 no 1212 0.383769671505628 1857 3938802 SGTC_3257 9139206 32.98 µM 0.294489574024042 0.375882913659665 no 1213 0.384191914559318 1874 4910041 SGTC_1977 st070720 65.3 µM 0.294389891111451 0.375920601164001 no 1214 0.384229995288651 1783 682188 SGTC_2130 NSC 7 2.4545 µM 0.294154443885218 0.376009622306149 no 1215 0.384319944950972 1896 21448 SGTC_1620 st003704 16.5 µM 0.293720182554541 0.376173831138824 no 1216 0.384485865389065 1915 2834414 SGTC_2047 4141938 200 µM 0.293028844179682 0.376435295703508 no 1217 0.384750052218104 1801 3807862 SGTC_2081 5214970 32.255 µM 0.292674484258216 0.376569336816524 no 1218 0.384885487450631 1897 2063512 SGTC_1142 3253-1408 9.78 µM 0.292116660160592 0.376780370972803 no 1219 0.385098714497358 1904 256655 SGTC_462 ag-879 158 µM 0.291153575059329 0.377144808761023 no 1220 0.385466933430913 1901 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2537 larixol 68.93 µM 0.290149012838895 0.377525058397375 no 1221 0.385851120450805 1828 6708759 SGTC_2790 5423970 71.43 µM 0.28988620280173 0.377624557582085 no 1222 0.385951648605731 1894 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_781 4335-2806 94.4 µM 0.28886909259111 0.378009709298711 no 1223 0.38634077821517 1917 845254 SGTC_2174 5790901 200 µM 0.288251952509534 0.37824346245163 no 1224 0.386576941605974 1797 786020 SGTC_1500 4488-1866 171 µM 0.286455642877562 0.378924101144268 no 1225 0.387264581214452 1893 2900003 SGTC_592 k241-0073 46.5 µM 0.286197799392864 0.379021831353969 no 1226 0.387363314558434 1907 4230158 SGTC_1439 4092-1168 46 µM 0.285322159046971 0.379353782309888 no 1227 0.38769866882902 1835 2886240 SGTC_874 0599-0792 117 µM 0.285079083001543 0.379445947031696 no 1228 0.38779177738732 1958 765305 SGTC_2356 9061756 188.97 µM 0.284694306390967 0.379591852948597 no 1229 0.387939176532488 1924 20104043 SGTC_1081 sertraline 6 µM 0.281505396323111 0.380801734391051 no 1230 0.389161394850394 1917 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_365 0121-0052 13.6 µM 0.280773375083194 0.381079630358147 no 1231 0.389442113044719 1862 3101739 SGTC_2595 hexamethylquercetagetin 100 µM 0.279940818278021 0.381395767022464 no 1232 0.389761455113222 1823 386331 SGTC_898 1000-0849 28.3 µM 0.279882287822967 0.381417995060164 no 1233 0.389783908320023 1932 6751807 SGTC_3121 9125696 49.47 µM 0.279821528954453 0.381441069793417 no 1234 0.38980721677051 1973 1235365 SGTC_1413 3910-0535 34.4 µM 0.279782306630919 0.381455965697093 no 1235 0.38982226353483 1899 2876951 SGTC_2504 purpurogallin 52.29 µM 0.279724869599702 0.381477779522345 no 1236 0.389844298260977 1779 5281571 An antioxidant. SGTC_757 1066-0008 322 µM 0.279678525371319 0.381495380722149 no 1237 0.389862077682756 1882 6842497 SGTC_218 alverine citrate 93.75 µM 0.278894287625318 0.381793265631063 no 1238 0.39016297624835 1891 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1684 st024538 14.6195 µM 0.278213116169309 0.382052058655691 no 1239 0.3904243834659 1794 6732859 SGTC_2508 celastrol 40.54 µM 0.277875741015191 0.382180254921055 no 1240 0.390553873333866 1871 122724 Celastrol is a natural product and antioxidant. SGTC_1402 3909-7673 35.9 µM 0.277795029857168 0.382210925570813 no 1241 0.390584853340435 1784 5328014 SGTC_352 k048-0007 5.11 µM 0.277355387640791 0.38237800481799 no 1242 0.390753616905592 1867 6811911 SGTC_1953 st076800 12.1 µM 0.276954259990648 0.382530466305557 no 1243 0.390907614005214 1726 297591 SGTC_1740 st038286 13.222 µM 0.276952311362293 0.382531206989009 no 1244 0.390908362145794 1842 716786 SGTC_3206 9114350 49.47 µM 0.275624805216419 0.383035898491146 no 1245 0.391418127789529 1884 17087243 SGTC_1637 st007924 17.4 µM 0.275372741509623 0.383131750575087 no 1246 0.391514941975961 1795 683336 SGTC_3105 9121040 49.47 µM 0.274691708673277 0.383390762210003 no 1247 0.391776550867831 1939 41448907 SGTC_470 aa-861 153 µM 0.273214469112521 0.383952767642814 no 1248 0.392344179108607 1804 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_360 0957-0399 1.01 µM 0.271899487960561 0.384453248436416 no 1249 0.392849652479448 1914 6752301 YPR165W RHO1 SGTC_2379 9035213 200 µM 0.271081116641076 0.384764817238079 no 1250 0.393164322368555 1977 646551 SGTC_2939 9044578 71.43 µM 0.268987544645267 0.385562216407563 no 1251 0.393969633742574 1784 2653634 SGTC_775 4577-0580 57.3 µM 0.268152536341808 0.385880389347923 no 1252 0.394290953956018 1886 2006902 SGTC_2223 6903751 107.57 µM 0.267812035831415 0.386010156276095 no 1253 0.394422002895075 1895 5598863 SGTC_1778 st046819 58.9 µM 0.266176761127695 0.386633547436845 no 1254 0.395051539778024 1807 671715 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.265843577047572 0.386760598129126 no 1255 0.395179840370292 1862 6708739 YPR165W RHO1 SGTC_3127 9126946 49.47 µM 0.265828947697461 0.386766176912383 no 1256 0.395185474016096 1759 27243249 SGTC_2774 tamoxifen 10.92 µM 0.261920564155434 0.388257441754674 no 1257 0.396691342508891 1859 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1138 3761-0006 1.03 µM 0.261534083026567 0.388404995662282 no 1258 0.39684033470153 1879 12061087 SGTC_3242 9133940 49.47 µM 0.261329114506754 0.388483256747752 no 1259 0.396919358150451 1909 17248444 SGTC_1649 st011737 51.3 µM 0.260188102446952 0.388919000667198 no 1260 0.397359340587184 1834 1761035 SGTC_350 k064-0020 19.8 µM 0.258825318954004 0.389439620553718 no 1261 0.397885010829969 1982 2790705 SGTC_2095 5432005 200 µM 0.257425193402448 0.389974712844547 no 1262 0.398425278260064 1843 783734 SGTC_401 neomycin 50 µM 0.256072401527857 0.390491913541584 no 1263 0.398947466018798 1875 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3134 9127454 49.47 µM 0.255780732532722 0.390603450146259 no 1264 0.39906007616732 1914 24262820 SGTC_2450 5739737 12.93 µM 0.255559830895501 0.39068793072709 no 1265 0.399145369419155 1851 2262825 SGTC_1365 1672-3266 55.4 µM 0.255467784871341 0.390723133897921 no 1266 0.399180911114642 1960 6415873 SGTC_2372 9071633 200 µM 0.253893814019664 0.391325240314989 no 1267 0.399788796969511 1990 21321366 SGTC_2104 5389443 200 µM 0.252896220543057 0.391706994450278 no 1268 0.400174205066803 1935 2244536 SGTC_1974 st069448 26.9 µM 0.25188114984221 0.392095543745499 no 1269 0.400566465091207 1975 6323587 YNR016C ACC1 SGTC_1741 st038134 10.228 µM 0.250862473064189 0.392485581577163 no 1270 0.400960219473665 1949 1272587 SGTC_2706 st078239 82.5 µM 0.24992001913924 0.392846530896524 no 1271 0.401324600675042 1906 15434492 SGTC_1463 k081-0032 34.1 µM 0.248940237994196 0.393221873833328 no 1272 0.401703504707349 1887 977755 SGTC_3051 9093778 49.47 µM 0.248585718203708 0.393357710783246 no 1273 0.401840628501278 1932 17217378 SGTC_780 0109-0199 192 µM 0.248553011013997 0.393370243445717 no 1274 0.401853279839841 1996 610414 SGTC_254 nsc-64875 3.808 µM 0.247283322264245 0.393856845010227 no 1275 0.40234448248679 1989 56993 SGTC_2940 9060638 45.86 µM 0.247106896700385 0.393924472318353 no 1276 0.402412748211582 1868 4027022 SGTC_3256 9138902 49.47 µM 0.245784982616526 0.394431289029802 no 1277 0.402924341334137 1939 17228773 SGTC_3296 9122258 64.045 µM 0.245601113429822 0.394501797941035 no 1278 0.402995513619456 1880 4730474 SGTC_2799 7812892 81.82 µM 0.245567271019116 0.394514775976352 no 1279 0.403008613726999 1967 20205235 SGTC_629 3448-6466 76.7 µM 0.245475228784046 0.39455007332646 no 1280 0.403044243039108 1881 573744 SGTC_734 2023-0417 80 µM 0.24329060667832 0.395388109331311 no 1281 0.403890140305598 1931 3935732 SGTC_2423 st077119 87.2 µM 0.242401565419792 0.395729290433032 no 1282 0.404234510756304 1928 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2924 9010168 62.78 µM 0.242334379326671 0.395755077217754 no 1283 0.404260538333261 1869 2993929 SGTC_1313 1220-0047 237 µM 0.242180581929059 0.395814108121288 no 1284 0.40432012031799 1919 3528706 SGTC_822 1487-0950 154 µM 0.240927709162189 0.396295077806895 no 1285 0.40480557289754 2001 1958375 SGTC_249 wiskostatin 11.211 µM 0.240438701978527 0.396482847353818 no 1286 0.404995089083435 1971 2775510 A n-wasp and actin depolymerizer. SGTC_1189 1431-2119 7.28 µM 0.239982359999109 0.396658095737648 no 1287 0.405171965874114 1899 3107275 SGTC_2507 purpurin 79.67 µM 0.23899861031932 0.397035954744512 no 1288 0.405553330162866 1784 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1167 k781-0610 148 µM 0.237803725248656 0.397495041017066 no 1289 0.40601666460792 1871 4525169 SGTC_2154 5570129 200 µM 0.237473339392608 0.397622003513269 no 1290 0.406144799897891 1958 673366 SGTC_1965 Pectolinarigenin 58.4 µM 0.237405826631265 0.397647949023965 no 1291 0.406170984965921 1867 5320438 An anti-inflammatory. SGTC_73 0327-0325 16.231 µM 0.237137878645586 0.397750927313154 no 1292 0.40627491369598 2038 53298 SGTC_533 1222-0222 6.71 µM 0.236818584086074 0.397873648520442 no 1293 0.406398766795559 1991 3982874 SGTC_2170 morpholine 200 µM 0.236312040716131 0.39806835973808 no 1294 0.406595272179465 1967 121171 Reacts with secondary amines. SGTC_3315 9136395 68.55 µM 0.235322146310506 0.398448940468128 no 1295 0.406979353711821 2030 16876844 SGTC_381 3461-2219 42.7 µM 0.23483162302185 0.398637565808318 no 1296 0.407169711166252 1991 2883159 SGTC_648 0375-0473 33.3 µM 0.234015978009404 0.398951265539908 no 1297 0.407486287188057 1888 1713139 SGTC_2776 terbinafine 19.92 µM 0.233996816403897 0.398958635941464 no 1298 0.407493725102804 1973 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_843 0310-0051 143 µM 0.233648912979944 0.399092461258907 no 1299 0.407628775742895 1907 2065037 SGTC_697 0508-1955 564 µM 0.233108278990437 0.399300446283274 no 1300 0.407838663138664 2022 6243113 SGTC_2906 7926292 26.41 µM 0.23277771677896 0.399427629565506 no 1301 0.407967008545234 1890 2966319 SGTC_78 0336-0123 156.75 µM 0.232761898609618 0.399433715848581 no 1302 0.407973150418653 1809 6765896 SGTC_3052 9092717 49.47 µM 0.231836759578127 0.39978971973791 no 1303 0.408332402376385 1873 25237534 SGTC_854 0422-0053 192 µM 0.231201046865226 0.400034397444034 no 1304 0.408579308377424 1965 3596728 SGTC_3027 9089541 49.47 µM 0.231061268329827 0.400088201684624 no 1305 0.408633602172003 1879 9943819 SGTC_2280 7785178 200 µM 0.229659057240041 0.400628052448103 no 1306 0.409178356057547 1895 2954328 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.229104075466069 0.400841772733318 no 1307 0.409394012970009 1984 23847180 SGTC_3331 9141060 1.957 µM 0.228778342635279 0.400967224398031 no 1308 0.409520600237501 1853 4906567 YPR165W RHO1 SGTC_532 1548-0774 215 µM 0.227670435908102 0.40139399629778 no 1309 0.409951228800133 2011 5932993 SGTC_2416 tofa 880 nM 0.227648424557896 0.401402476387278 no 1310 0.409959785420519 1757 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_939 1165-0479 45.3 µM 0.226456707503627 0.401861666340448 no 1311 0.410423113512755 2028 1377347 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.225762551347304 0.402129199653681 no 1312 0.410693052405385 1864 6312947 SGTC_11 0438-0307 1.3 µM 0.225070794357177 0.4023958539313 no 1313 0.410962100413707 2035 4011476 SGTC_1133 3473-0247 50 µM 0.222260217202708 0.403479724070507 no 1314 0.412055659813205 1788 711311 SGTC_1550 gossypolone 36.6 µM 0.222199166896306 0.403503275753649 no 1315 0.412079421314257 2014 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_49 0717-0965 32.132 µM 0.221625015523224 0.403724786120843 no 1316 0.412302903575607 1988 5889349 YGL099W LSG1 SGTC_183 3914-0051 30.55 µM 0.221593032017063 0.40373712642042 no 1317 0.412315353649083 2054 1596232 SGTC_1135 dihydrocapsaicin 536.708 nM 0.221512170982718 0.40376832572205 no 1318 0.4123468304484 1784 107982 A Capsaicinoid. SGTC_2502 avocadyne acetate 18.59 µM 0.221171898898129 0.403899622506167 no 1319 0.412479294441772 2005 3952079 SGTC_871 0574-0004 149 µM 0.220767242119534 0.404055776748802 no 1320 0.412636835629319 1901 9551173 SGTC_2865 9030313 51.95 µM 0.217415153133401 0.405349910334433 no 1321 0.413942411565842 1837 42562754 SGTC_2351 9026858 72.31 µM 0.21671996190596 0.405618431385974 no 1322 0.414213295174549 1874 1409300 SGTC_138 0850-0259 40.9225 µM 0.21667847568328 0.405634457050521 no 1323 0.414229461713019 2022 6813004 SGTC_194 1486-1323 56.904 µM 0.213369473939635 0.40691319472516 no 1324 0.415519394266222 1889 5178754 SGTC_1691 st019933 84.6 µM 0.213225779967911 0.406968746724231 no 1325 0.415575430547949 2070 6176082 SGTC_2990 9074105 71.4286 µM 0.21200593535504 0.407440413165294 no 1326 0.416051201915823 1981 6502001 SGTC_2540 epiandrosterone 100 µM 0.211712364180746 0.407553945778242 no 1327 0.416165720764351 2070 441302 A steroid. SGTC_2187 6125751 200 µM 0.21130035816777 0.407713293723068 no 1328 0.416326451727914 1966 874498 SGTC_1908 st060353 56.5 µM 0.210615682618642 0.407978133426722 no 1329 0.416593586923322 2072 4227716 SGTC_2541 muurolladie-3-one 83.07 µM 0.21041081403143 0.408057386930024 no 1330 0.416673526598253 1972 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2483 5729050 27.16 µM 0.210296833612342 0.408101481934274 no 1331 0.416718003223328 2041 2865180 SGTC_3082 9117008 49.47 µM 0.210123420703873 0.408168571504812 no 1332 0.416785673214629 1912 41448529 SGTC_2232 chlorophetanol 41.5365 µM 0.209201577008877 0.40852525733334 no 1333 0.417145440694027 2004 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1958 st076513 41.9 µM 0.209179461595111 0.408533815306858 no 1334 0.417154072518998 1906 732122 YGL099W LSG1 SGTC_1004 4084-0029 199 µM 0.208768715369343 0.408692769174914 no 1335 0.417314397348805 2047 716894 YLR208W SEC13 SGTC_331 k048-0133 24.5 µM 0.208235147615023 0.408899275928759 no 1336 0.417522683110279 1916 6813582 SGTC_2634 4'-methoxyflavone 100 µM 0.207544414253597 0.409166648050566 no 1337 0.417792355066427 1896 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_228 caffeine 993.056 µM 0.205702524748505 0.40987982107263 no 1338 0.418511643136335 2045 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2432 5630864 12.22 µM 0.205606455655659 0.409917026885132 no 1339 0.418549167192742 1921 5714970 SGTC_1029 k015-0030 64.7 µM 0.205540805207756 0.409942452576187 no 1340 0.418574810320991 1963 2208316 SGTC_1912 st060209 90.8 µM 0.204631433118798 0.410294681214145 no 1341 0.418930047481735 1886 688787 SGTC_618 k072-0232 33.2 µM 0.204295220945842 0.410424925188422 no 1342 0.419061402177306 1959 5872756 YGL099W LSG1 SGTC_2650 prasterone 100 µM 0.203446377696719 0.41075379932384 no 1343 0.419393076763398 2001 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2070 5230947 200 µM 0.203261848601276 0.410825301219961 no 1344 0.419465186722784 2059 2835538 SGTC_897 1000-0139 31.4 µM 0.201267329120137 0.411598332339051 no 1345 0.420244773701204 2063 6151020 SGTC_1441 4106-0040 13 µM 0.199150887736265 0.412418993010522 no 1346 0.421072357863538 2045 2904180 SGTC_1203 3992-3522 103 µM 0.198472807815386 0.412682003066541 no 1347 0.42133757888759 2102 5322312 SGTC_3162 9099653 49.47 µM 0.19684894307862 0.413312018301481 no 1348 0.421972874662342 2066 25237511 SGTC_829 1635-0120 117 µM 0.196746994672675 0.413351578968566 no 1349 0.422012766175854 2058 285054 SGTC_3286 9117135 37.221 µM 0.196465246903478 0.413460914626139 no 1350 0.422123015757031 1887 3438150 SGTC_1642 st009582 77.7 µM 0.194545745615923 0.41420597868412 no 1351 0.422874290037054 2083 6739311 SGTC_45 0kpi-0036 14.9 µM 0.192374572416471 0.415049102607183 no 1352 0.423724404333214 1980 2795021 SGTC_2949 9072542 2.23 µM 0.19202687886757 0.415184157658355 no 1353 0.423860575461052 1938 16457352 SGTC_1450 4112-4260 37.6 µM 0.191475383476337 0.415398396271269 no 1354 0.42407658243378 2062 1633175 SGTC_157 1348-1695 65.819 µM 0.190816076403276 0.415654549337454 no 1355 0.424334846480511 1990 5380510 SGTC_2281 7943571 200 µM 0.189973962991775 0.415981778184743 no 1356 0.424664766745731 2128 1244024 SGTC_2571 chrysanthemic acid 100 µM 0.189062772454208 0.416335914671947 no 1357 0.425021809257433 1881 2743 An insecticide. SGTC_513 4245-1575 41.7 µM 0.188949446415901 0.4163799638762 no 1358 0.42506621943957 2034 719745 SGTC_795 0685-0265 78 µM 0.188632162791836 0.416503295850416 no 1359 0.425190561530608 2086 302754 SGTC_2076 5212012 200 µM 0.188614314378159 0.416510233988569 no 1360 0.425197556468564 2032 604802 SGTC_598 3937-0236 20.2 µM 0.187828351328324 0.416815783833957 no 1361 0.425505605076296 2023 1379313 SGTC_2870 9038528 12.99 µM 0.187451439028229 0.416962329549703 no 1362 0.425653347389701 1981 6463316 SGTC_1271 0832-2808 169 µM 0.185317128341121 0.417792379163492 no 1363 0.426490152117653 2089 3663794 SGTC_3274 9138298 49.47 µM 0.185020568948903 0.417907742434241 no 1364 0.426606451206083 2088 17015756 SGTC_2207 7258803 200 µM 0.184879761527991 0.417962519786516 no 1365 0.426661672648744 2048 3666799 SGTC_1380 2291-0730 164 µM 0.184659521921497 0.418048201292249 no 1366 0.426748048456063 1927 2999191 SGTC_1048 3161-0300 24.5 µM 0.182880039989179 0.418740629152808 no 1367 0.427446072273636 2036 2165101 SGTC_1139 k015-0024 46.9 µM 0.182294716000146 0.418968444204396 no 1368 0.427675722615414 2101 2766652 SGTC_3310 9130229 44.1445 µM 0.179396789860335 0.420096750368113 no 1369 0.428813075910433 2061 7761258 SGTC_2322 7413319 38.22 µM 0.178702811373835 0.420367048418664 no 1370 0.429085530782302 1990 1840400 SGTC_2117 5521686 200 µM 0.178199311600658 0.420563180330498 no 1371 0.429283225167185 1956 803312 SGTC_417 st075190 100 µM 0.176487426710682 0.421230170485783 no 1372 0.429955512838015 2116 222757 SGTC_1619 st003326 88.7 µM 0.176481772815787 0.42123237375037 no 1373 0.429957733560817 2091 2849032 SGTC_3253 9135987 49.47 µM 0.175775677543411 0.421507551170051 no 1374 0.430235089305168 2039 4182430 SGTC_1394 3474-0001 65.7 µM 0.174702049817521 0.421926035704223 no 1375 0.430656878512949 1994 5017666 YIL048W NEO1 SGTC_34 0469-0683 81.75 µM 0.173295339100753 0.422474484547567 no 1376 0.431209643563086 2050 3690923 SGTC_844 0330-0132 15.3 µM 0.172531792555768 0.422772239344366 no 1377 0.431509734627925 2088 2828079 SGTC_1467 k284-1082 293 µM 0.17233903021362 0.422847416482201 no 1378 0.431585500846043 2132 3334705 SGTC_56 0957-0365 83.25 µM 0.172139403428505 0.422925273708189 no 1379 0.431663967821394 2101 6752360 SGTC_1616 st002734 56.1 µM 0.171492177050945 0.423177721696111 no 1380 0.431918390567512 2010 4026101 SGTC_3226 9131256 49.47 µM 0.17106193078421 0.423345554944641 no 1381 0.432087534716304 2063 17178073 SGTC_2828 7998861 71.43 µM 0.169583639464203 0.423922322211294 no 1382 0.432668794994172 2126 2988188 SGTC_2294 7971431 200 µM 0.167745868218239 0.424639570619015 no 1383 0.433391604902965 2067 5741572 SGTC_2074 5212007 75.395 µM 0.166295023281926 0.425205985213488 no 1384 0.433962391182059 2137 758611 SGTC_2441 5730946 39.09 µM 0.165847797272753 0.42538061489717 no 1385 0.434138365080941 2059 1774275 SGTC_3302 9125395 16.351 µM 0.164910009352676 0.425746843260514 no 1386 0.434507406972836 2010 17599668 SGTC_1673 st016611 27.3 µM 0.163930538523923 0.426129418179647 no 1387 0.4348929130163 2088 5226799 SGTC_3196 9111891 49.47 µM 0.163698999059883 0.426219866159185 no 1388 0.434984052776562 2120 18891510 SGTC_474 dl-dihydrosphingosine 5 µM 0.163674365270317 0.426229489267758 no 1389 0.4349937494595 2092 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2867 9039098 71.43 µM 0.163583879829453 0.426264837483477 no 1390 0.435029367888944 2017 6463460 SGTC_1744 st037937 38.9 µM 0.163367156111842 0.426349503199159 no 1391 0.435114680534712 2063 1016152 SGTC_2306 7482397 179.52 µM 0.16319210897586 0.426417889937344 no 1392 0.43518358952361 2099 891448 SGTC_116 0155-0182 31.788 µM 0.16198200336385 0.426890709723039 no 1393 0.435660012968751 1974 771486 SGTC_804 1595-0054 20.9 µM 0.160853654818108 0.427331679566146 no 1394 0.436104332485587 1977 761523 Stimulates phospholipase C. SGTC_1885 st057546 99.9 µM 0.160507831346836 0.427466849027323 no 1395 0.436240526542473 2111 702008 SGTC_3300 9124615 50.48 µM 0.158626632768799 0.428202287932596 no 1396 0.436981522275227 2104 24824903 SGTC_1506 4226-2149 212 µM 0.157996368788104 0.428448740296803 no 1397 0.437229830032514 2042 991114 SGTC_108 0509-0257 621.132 µM 0.157878784528876 0.428494722406196 no 1398 0.437276157938638 2108 536624 SGTC_746 1095-0025 46.6 µM 0.15761318542972 0.428598590278519 no 1399 0.437380806488514 2096 6749286 SGTC_3241 9133421 49.47 µM 0.154961428390956 0.429635883266965 no 1400 0.438425862803176 2128 17018221 SGTC_2786 7743617 45.45 µM 0.154798497376057 0.429699633230237 no 1401 0.438490087925911 1969 583674 SGTC_2147 5545932 89.7195 µM 0.154196521470178 0.429935184025228 no 1402 0.438727392427406 2025 797404 SGTC_47 0149-0135 24.25 µM 0.152611083451837 0.430555678792986 no 1403 0.439352492030269 2087 5239155 SGTC_920 mycophenolic acid 780.421 nM 0.149142979827207 0.431913590474625 no 1404 0.440720406064031 2011 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1602 st001878 87.6 µM 0.14889666736069 0.43201006319466 no 1405 0.440817585480997 2103 595405 YLR310C CDC25 SGTC_1257 0669-0121 16 µM 0.146893489902068 0.432794793848435 no 1406 0.441608045243692 2113 4307855 SGTC_1449 4112-4002 201 µM 0.146457439495283 0.432965648765977 no 1407 0.44178014296483 1974 2059539 SGTC_338 4055-0136 114 µM 0.145495666347837 0.433342538612257 no 1408 0.442159768548731 2114 2900563 SGTC_445 e6 berbamine 66 µM 0.145297626128788 0.43342015213085 no 1409 0.44223794445604 2056 6610268 A calcium/calmodulin antagonist. SGTC_271 rotenone 740 µM 0.145170520528637 0.433469967167744 no 1410 0.442288120275988 2086 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_277 nystatin 15.5 µM 0.143315384126146 0.434197149342865 no 1411 0.443020553237375 2131 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2135 5326629 150.42 µM 0.140903945103657 0.435142725337896 no 1412 0.443972912751187 2020 5020077 SGTC_2727 riluzole 51.77 µM 0.140111059440844 0.435453713809823 no 1413 0.444286121309826 2187 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_660 4031-1742 102 µM 0.140109520462386 0.435454317472382 no 1414 0.444286729276554 2039 6738706 SGTC_2903 5923464 63.88 µM 0.140106451703899 0.435455521189876 no 1415 0.444287941576601 2171 2876576 SGTC_2734 clemastine 41.6 µM 0.140065578702644 0.435471553641388 no 1416 0.444304088332397 2167 26987 Clemastine is a selective histamine H1 antagonist. SGTC_206 4546-0025 72.014 µM 0.139493746402648 0.435695866206089 no 1417 0.444529998638077 2054 6620745 YIL048W NEO1 SGTC_222 nsc-310342 10.666 µM 0.139376011826078 0.435742052500314 no 1418 0.444576513560026 2169 432556 SGTC_392 N-ethylmaleimide 8.33 µM 0.139353896848439 0.435750728119723 no 1419 0.44458525089545 2042 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1807 st050092 58.9 µM 0.13823101113122 0.436191272354976 no 1420 0.445028923505892 2063 5008496 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.137971896051458 0.436292942809538 no 1421 0.445131314395987 2090 65057 A dermal irritant. YDR527W RBA50 SGTC_2431 5490079 200 µM 0.136010722849256 0.437062595500166 no 1422 0.445906402066203 2055 5722345 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.135416705134087 0.43729576195103 no 1423 0.446141208499991 2185 5024745 SGTC_3103 9120822 49.47 µM 0.135193883520921 0.437383230493935 no 1424 0.446229291470221 2155 17141819 SGTC_3099 9120367 49.47 µM 0.13294123348869 0.438267678588955 no 1425 0.447119928346633 2158 24824940 SGTC_2142 5622915 118.518 µM 0.131967461667636 0.438650102084877 no 1426 0.447505014219997 2060 5322196 SGTC_2060 5238662 140 µM 0.13071443341067 0.439142280500058 no 1427 0.448000607051983 2063 790130 SGTC_1182 1222-0449 220 µM 0.130618732504362 0.439179874847102 no 1428 0.448038461646392 2115 658318 SGTC_1893 st059353 36.1 µM 0.129370498980075 0.439670270629181 no 1429 0.448532244944505 2025 3112488 SGTC_230 MPP+ 141.667 µM 0.128751881945031 0.439913342192162 no 1430 0.448776990581188 2037 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_32 0928-0142 34.1 µM 0.128314633604275 0.44008516269987 no 1431 0.448949992446908 2176 2244242 SGTC_1765 st044815 90.4 µM 0.127472201083906 0.440416235612969 no 1432 0.449283336996696 2015 645695 SGTC_3002 9075603 71.4286 µM 0.126347764099603 0.440858200125894 no 1433 0.44972832444428 2200 20105405 SGTC_2657 nystatin 74.44 µM 0.126169770477904 0.440928168008511 no 1434 0.449798769886699 2142 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1769 st044406 64.4 µM 0.125956518604846 0.441011998058323 no 1435 0.449883171749836 2031 670903 SGTC_3273 9137859 49.47 µM 0.125947043213126 0.441015722928982 no 1436 0.449886922019073 2226 2377234 SGTC_2684 capsaicin 100 µM 0.125669866113274 0.44112468630925 no 1437 0.449996628037848 2127 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_371 0195-0006 7.36 µM 0.125238156915388 0.441294407953569 no 1438 0.45016750509146 2106 3928593 SGTC_2833 9001315 45.46 µM 0.124265732202612 0.441676745303538 no 1439 0.450552439349165 2035 2989378 SGTC_1047 2043-3044 82 µM 0.124163750917789 0.441716845397264 no 1440 0.450592811335209 2107 669592 SGTC_833 3852-0053 558 µM 0.124096450303669 0.441743309020551 no 1441 0.450619454341482 2134 3123681 SGTC_2891 9063876 19.48 µM 0.123481026382514 0.44198531509694 no 1442 0.450863099027322 2231 6472478 SGTC_1212 0520-0165 585 µM 0.123356751170264 0.442034187060819 no 1443 0.450912301501726 2200 5403258 SGTC_1191 1487-1166 10.6 µM 0.123102798493462 0.442134058199249 no 1444 0.451012847630333 2140 3955771 SGTC_815 1582-0027 36.9 µM 0.123027401308703 0.442163710111851 no 1445 0.451042699840933 2117 3128206 SGTC_2297 7971671 152.32 µM 0.122625859954233 0.442321632193933 no 1446 0.451201687852049 2161 909016 SGTC_2368 9071271 200 µM 0.122019667589236 0.442560058768724 no 1447 0.451441721086859 2074 27209959 SGTC_2066 5222451 176 µM 0.121541455568156 0.442748163011905 no 1448 0.451631090636999 2186 2281147 SGTC_163 TUB2.036 7.546 µM 0.120495859958947 0.443159491951126 no 1449 0.452045179513012 2212 15992207 YJR013W GPI14 SGTC_1040 k898-0338 155 µM 0.11981258509959 0.443428319933858 no 1450 0.452315806147159 2226 20969351 SGTC_3223 9129970 49.47 µM 0.119239638885485 0.443653760239358 no 1451 0.452542751681692 2149 17248386 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.118832512749426 0.443813965492514 no 1452 0.452704024865413 2110 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1002 4049-0206 172 µM 0.118699911629163 0.443866146381362 no 1453 0.452756553281693 2118 4662749 SGTC_542 3381-0244 89.3 µM 0.118361100243803 0.443999479079047 no 1454 0.452890773287612 2201 1112843 SGTC_569 4130-2812 160 µM 0.118092899064874 0.444105028985052 no 1455 0.452997024903778 2237 743552 SGTC_3158 9100007 49.47 µM 0.116567631771746 0.444705369296289 no 1456 0.453601344459303 2083 19297233 SGTC_1295 1013-0063 9.78 µM 0.114218268245725 0.445630318962258 no 1457 0.454532385355874 2216 6826038 SGTC_1026 k007-1105 30.6 µM 0.113312204613305 0.445987117606189 no 1458 0.45489152083862 2183 7066794 SGTC_3350 9150499 3.57 µM 0.113275368467879 0.446001624232924 no 1459 0.454906122324578 2207 4910996 YPR165W RHO1 SGTC_1274 0865-0114 173 µM 0.112926996042537 0.446138822092422 no 1460 0.455044216739646 2117 870624 SGTC_2973 9094665 17.96 µM 0.112881486433818 0.446156745402306 no 1461 0.455062257095986 2191 25237061 YIL048W NEO1 SGTC_1395 3486-0190 4.35 µM 0.112309865269385 0.446381879597147 no 1462 0.455288859970123 2209 6748079 SGTC_2868 9035608 32.47 µM 0.111776393210159 0.446592004281383 no 1463 0.455500352847342 2221 6462614 SGTC_2844 9010103 25.97 µM 0.111214337538292 0.446813403739163 no 1464 0.45572319122633 2092 2480525 SGTC_3255 9139072 49.47 µM 0.111068386144964 0.446870898194767 no 1465 0.4557810588996 2113 17646060 SGTC_3299 9121982 43.1275 µM 0.110547091751531 0.447076260172595 no 1466 0.455987752439947 2094 17594604 YPL160W CDC60 SGTC_51 1013-0126 23.419 µM 0.108593760509687 0.447845893486833 no 1467 0.456762354939334 2252 1627850 SGTC_1994 st072947 40.9 µM 0.108035378993428 0.448065937971456 no 1468 0.456983814030093 2126 5286565 YDL195W SEC31 SGTC_877 0771-0151 33.1 µM 0.107731592313427 0.448185659581198 no 1469 0.45710430415328 2122 6166523 SGTC_370 0180-0345 38.7 µM 0.106581967206209 0.448638766742226 no 1470 0.457560312584619 2131 3989527 SGTC_1462 k081-0014 26.5 µM 0.104159472006322 0.449593774842119 no 1471 0.458521397813758 2190 3270634 SGTC_2506 ethyl hematommate 54.16 µM 0.103799827771169 0.449735580610105 no 1472 0.458664101575426 2028 3940691 An allergen. SGTC_674 0498-0004 451 µM 0.102638678339416 0.450193459249401 no 1473 0.459124872028803 2082 4231473 SGTC_966 1300-0360 30.2 µM 0.100998405503408 0.450840384539012 no 1474 0.459775862964541 2144 70588 SGTC_195 4234-0266 16.654 µM 0.100105093325778 0.451192762825862 no 1475 0.460130445878866 2105 2303354 SGTC_235 0330-0087 5 mM 0.0983621766078012 0.451880388858962 no 1476 0.460822353843606 2193 46494818 YHR062C RPP1 SGTC_3219 9131112 49.47 µM 0.0981370062449416 0.451969235005891 no 1477 0.460911751302481 2249 17612988 YMR079W SEC14 SGTC_2680 butyl paraben 22.24 µM 0.0979714604507474 0.452034556442155 no 1478 0.460977477790336 2246 7184 An antifungal and steroid mimetic. SGTC_1736 st036774 51 µM 0.0976569059308872 0.452158677656721 no 1479 0.46110236800525 2242 1272247 SGTC_1184 1269-1718 139 µM 0.0976046773337901 0.452179287182207 no 1480 0.461123105134206 2223 5403821 SGTC_2982 9019404 25.97 µM 0.0974763468537481 0.452229927234292 no 1481 0.461174058621477 1995 22333232 SGTC_3043 9092303 49.47 µM 0.0974520627045368 0.452239510006876 no 1482 0.461183700690098 2157 25236084 SGTC_524 r073-0010 27.8 µM 0.0969517896992176 0.452436929011911 no 1483 0.461382340127568 2100 2772106 SGTC_789 1309-1135 70.6 µM 0.0950055037563948 0.453205088742856 no 1484 0.462155227665968 2248 3092424 SGTC_782 0083-0095 30.5 µM 0.0949703610646887 0.453218960471402 no 1485 0.462169184465238 2272 3591729 An indicator and reagent. SGTC_2655 perillic acid 100 µM 0.093160161747581 0.453933569737202 no 1486 0.462888161511668 2149 5702197 An apoptosis inducer. SGTC_2316 5844804 197.44 µM 0.0910795946204914 0.454755095744786 no 1487 0.463714673188135 2243 776813 SGTC_839 0122-0028 230 µM 0.0908668042001926 0.454839128451788 no 1488 0.463799213724741 2169 759448 SGTC_1486 3970-0793 4.53 µM 0.0907313144365709 0.454892635539819 no 1489 0.463853043961115 2248 2844330 SGTC_99 0109-0120 622.8 µM 0.0906054550686772 0.454942340162843 no 1490 0.463903048623258 2232 759414 SGTC_1351 1496-0003 46.5 µM 0.0904373685195909 0.455008722325301 no 1491 0.463969831280353 2226 3891978 SGTC_167 3672-0051 66.205 µM 0.0893736176780933 0.455428856869212 no 1492 0.464392494796393 2248 3237971 SGTC_3141 9094609 49.47 µM 0.0885196845368088 0.45576615879466 no 1493 0.46473181987611 2075 25236309 YDL196W YDL196W SGTC_2137 5261020 140 µM 0.0882922351421184 0.45585600624934 no 1494 0.464822205156854 2226 763655 SGTC_1832 st054113 55 µM 0.0871671524195395 0.456300471493147 no 1495 0.465269324259498 2267 1251267 SGTC_2674 ligustilide 100 µM 0.0870271402003042 0.456355787321336 no 1496 0.465324969592377 2204 5319022 A signalling regulator. SGTC_121 0557-0495 61.343 µM 0.0868752687509881 0.456415789433567 no 1497 0.465385328929072 2236 3104427 SGTC_217 ketoconazole 989 nM 0.0859259449880836 0.456790875360213 no 1498 0.465762643331915 2232 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1948 st076329 66.6 µM 0.085307282707562 0.457035334852657 no 1499 0.466008550938811 2267 24208413 SGTC_1900 st060200 72.8 µM 0.0849504463099191 0.457176343324095 no 1500 0.466150393172073 2226 688945 SGTC_1720 st037298 9.481 µM 0.0848120310296871 0.457231041346618 no 1501 0.466205414313285 2176 597396 SGTC_2624 nerol 100 µM 0.0844552527466392 0.457372034329933 no 1502 0.466347239407542 2227 637566 A natural product oil. SGTC_938 3126-1755 342 µM 0.0842157729193385 0.45746667587897 no 1503 0.466442438880914 2255 1777771 SGTC_2975 9084847 53.72 µM 0.0841022999426347 0.457511520825553 no 1504 0.466487548017562 2098 27211724 SGTC_100 0086-0128 49.5915 µM 0.0833466772670421 0.457810159513193 no 1505 0.466787943143164 2170 93297 SGTC_714 4296-0578 26.1 µM 0.0818488407162644 0.458402207684529 no 1506 0.467383458529152 2244 1589775 SGTC_2056 5235370 200 µM 0.0813583488926717 0.458596103961323 no 1507 0.467578486013269 2177 5511916 SGTC_1800 st050079 29.0735 µM 0.0811430405075267 0.458681220613005 no 1508 0.467664098571195 2234 3645560 SGTC_3104 9120930 49.47 µM 0.0804906872529214 0.458939123301785 no 1509 0.467923501349721 2169 17014836 SGTC_3054 9094397 49.47 µM 0.0795453276044836 0.459312894388313 no 1510 0.468299439796453 2232 2598354 SGTC_2529 gangaleoidin 93.61 µM 0.0795211817022716 0.459322441534487 no 1511 0.46830904219948 2223 4565183 SGTC_1763 st044482 94.5 µM 0.079461071900935 0.459346208694428 no 1512 0.468332946896295 2238 88505 SGTC_687 k029-0044 34.9 µM 0.0793781812187988 0.459378983556114 no 1513 0.468365911368609 2262 5829338 SGTC_3272 9137413 49.47 µM 0.079226598704693 0.459438919787555 no 1514 0.468426194188682 2280 17614870 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0790648240728918 0.45950288703323 no 1515 0.468490531108609 2261 2346 DNA damaging agent; causes G2/M arrest. SGTC_3330 9141424 71.43 µM 0.0780854460435118 0.459890164853729 no 1516 0.468880042109071 2255 27261020 SGTC_2465 5809242 33.21 µM 0.0778276666488814 0.45999210552448 no 1517 0.468982569194451 2271 2731748 SGTC_3246 9135460 32.98 µM 0.0776059886748055 0.460079771738644 no 1518 0.469070739238939 2237 41446951 SGTC_2005 4024620 188 µM 0.0772231189492238 0.460231188459853 no 1519 0.469223025149325 2254 236743 SGTC_1666 st014829 29 µM 0.0761959051074821 0.460637457819049 no 1520 0.469631620235592 2247 3858230 SGTC_2526 patulin 37.61 µM 0.0758189792123449 0.460786544644706 no 1521 0.469781558179135 2202 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_84 0443-0269 128.823 µM 0.0749932083902471 0.461113183920759 no 1522 0.470110057798425 2281 6150058 SGTC_638 3970-0837 4.09 µM 0.0745248597664559 0.461298454084839 no 1523 0.470296380465945 2198 4118451 YLR208W SEC13 SGTC_2427 5545055 42.75 µM 0.0743165926909251 0.461380843437734 no 1524 0.470379237241025 2218 5372858 SGTC_1552 6-methylflavone 10.6 µM 0.0736977056137219 0.46162568165755 no 1525 0.470625462240549 2282 689013 SGTC_428 3448-4153 16.5 µM 0.07320965258262 0.461818770818098 no 1526 0.470819642675849 2234 3834874 SGTC_647 0140-0236 81 µM 0.07286839528125 0.461953788310644 no 1527 0.470955421986878 2210 990837 SGTC_712 r015-0009 80.6 µM 0.0726650370858857 0.462034248495202 no 1528 0.47103633566635 2236 6813872 YLR060W FRS1 SGTC_1815 st051655 58.2 µM 0.0720992891657354 0.462258099037009 no 1529 0.471261445959302 2284 5984156 SGTC_2838 9002687 71.43 µM 0.0720167341177914 0.462290764749022 no 1530 0.471294295264916 2203 6457060 SGTC_2818 7996756 12.99 µM 0.069922233225385 0.463119609738503 no 1531 0.472127778441212 2263 2241621 SGTC_892 0929-0076 29 µM 0.0696361236838269 0.463232842760111 no 1532 0.472241642087402 2271 5751038 SGTC_575 k072-0246 11.9 µM 0.0678104744853986 0.463955446188367 no 1533 0.472968252761814 2275 6796779 SGTC_173 1273-0061 2.693 µM 0.0676824359880205 0.464006129120664 no 1534 0.473019215648435 2195 2847414 YPL266W DIM1 SGTC_456 gingerol 170 µM 0.066356405690961 0.464531060950232 no 1535 0.473547038443211 2238 442793 A herb. SGTC_286 k060-0067 22.9 µM 0.0650363623052432 0.465053684083955 no 1536 0.474072524296815 2250 5985051 SGTC_576 1073-0113 22.7 µM 0.063895310454144 0.465505490647499 no 1537 0.474526793183038 2313 5439563 SGTC_1105 epirubicin 18.1 µM 0.0638630439476524 0.465518267420277 no 1538 0.474539639420111 2265 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1682 st012968 530 nM 0.0636552953727255 0.465600531788871 no 1539 0.474622350818715 2137 24207270 SGTC_1921 5740136 50 µM 0.062605439176197 0.46601627670222 no 1540 0.47504034904012 2282 1774243 SGTC_917 harmaline 728.087 nM 0.0625000324354812 0.466058020014566 no 1541 0.475082318056117 2251 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3319 9138450 16.7555 µM 0.0618329183696132 0.466322220022216 no 1542 0.47534794428275 2170 2029690 SGTC_2197 6588183 93.1375 µM 0.060611038337569 0.466806164747351 no 1543 0.475834491183289 2287 884136 SGTC_1211 1056-0033 32.3 µM 0.0598298814227941 0.467115579940762 no 1544 0.476145563132831 2297 6741922 SGTC_1115 galangin 695.678 nM 0.0594191853214985 0.46727826409128 no 1545 0.47630911618984 2297 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2267 7931562 200 µM 0.0592403013070908 0.467349124993843 no 1546 0.476380355094849 2256 934880 SGTC_2139 5578692 56.4705 µM 0.0589293870077224 0.46747228920256 no 1547 0.476504175635295 2314 650991 YMR113W FOL3 SGTC_811 0416-0114 265 µM 0.058759327903205 0.467539656978662 no 1548 0.4765719020439 2176 6612453 SGTC_610 4215-0184 155 µM 0.0585663293099417 0.467616113205926 no 1549 0.476648764973588 2256 5605015 SGTC_2659 sanguinarine 24.21 µM 0.0570272732520112 0.468225851459703 no 1550 0.477261734787425 2304 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2395 5646831 180.19 µM 0.056639978535496 0.468379300424575 no 1551 0.477415993689735 2271 6808628 SGTC_1258 0671-0043 57.1 µM 0.0563467000203285 0.468495502618202 no 1552 0.477532808333328 2251 4298767 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.0561728778441023 0.46856437534109 no 1553 0.477602043691235 2293 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1143 3454-2408 5.08 µM 0.056154077680599 0.468571824495657 no 1554 0.477609532051613 2305 X1143 SGTC_1385 3091-4834 14.1 µM 0.0540306605807638 0.469413252368857 no 1555 0.478455368150688 2265 4072814 SGTC_1430 4049-0248 69.1 µM 0.053971476471213 0.46943670671137 no 1556 0.478478944793134 2296 22774488 SGTC_808 0711-0032 135 µM 0.0538174166151627 0.469497760296221 no 1557 0.478540316588004 2307 4252555 SGTC_1914 st062367 72.6 µM 0.0531995326530714 0.469742633554381 no 1558 0.478786463989294 2275 978205 SGTC_1307 1187-1599 12.2 µM 0.0525559111065225 0.469997719028425 no 1559 0.479042873114868 2255 1538471 SGTC_896 0964-0007 44.5 µM 0.0521242212817611 0.470168816855417 no 1560 0.479214856702223 2325 6756758 SGTC_2278 7948257 134.34 µM 0.0511032173676178 0.47057350785867 no 1561 0.479621636128054 2330 1247028 SGTC_1109 tnp00067 928.257 nM 0.0509929105546986 0.470617231530171 no 1562 0.479665584879069 2204 676295 SGTC_3007 9078383 71.4286 µM 0.0499247970741241 0.471040631083178 no 1563 0.480091158366072 2273 6496995 SGTC_2237 6667747 47.222 µM 0.0494897575082854 0.471213089919276 no 1564 0.48026449976171 2173 729940 YDL015C TSC13 SGTC_1128 3448-9350 235 µM 0.0493399780737739 0.471272466889017 no 1565 0.480324180201597 2174 619386 SGTC_2841 9004761 38.96 µM 0.0492366577835037 0.471313426460854 no 1566 0.480365348996943 2266 2991039 SGTC_912 3474-0017 2.18 µM 0.0479791667022235 0.471811961604687 no 1567 0.480866423022626 2298 3360550 SGTC_2018 5133068 143 µM 0.0471392729776212 0.47214496399592 no 1568 0.481201113401833 2321 785362 SGTC_543 3844-1095 191 µM 0.0456925420424919 0.472718611690808 no 1569 0.481777654095218 2282 4230703 SGTC_692 k241-0027 77.8 µM 0.0455977405043722 0.472756203726281 no 1570 0.481815435058579 2306 3600480 SGTC_1157 4092-0394 27.6 µM 0.044673519012803 0.473122701657516 no 1571 0.482183770692479 2321 3659885 SGTC_3137 9097352 49.47 µM 0.0444764250328559 0.473200861781204 no 1572 0.482262321737748 2289 44120435 SGTC_2866 9034245 58.44 µM 0.044065888372207 0.473363668623089 no 1573 0.48242594174728 2331 6462273 SGTC_479 n-linoleoylglycine 10 µM 0.0425059862708333 0.473982320550748 no 1574 0.483047669855521 2310 6433346 An anti-infammatory. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0424545068684736 0.47400273818639 no 1575 0.483068188643526 2320 688798 SGTC_774 k060-0086 136 µM 0.0423693492993774 0.47403651332469 no 1576 0.483102131057267 2330 5911235 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0420134391160683 0.474177676201542 no 1577 0.483243992355834 2298 5393153 SGTC_499 genistein 192 µM 0.0390175276065719 0.475366056385774 no 1578 0.484438207122336 2338 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1645 Cervolide 78 µM 0.038968742405743 0.475385409722831 no 1579 0.48445765481122 2303 23173 A fragrance. SGTC_491 tetrandrine 80.3 µM 0.0360666794561937 0.476536775724083 no 1580 0.485614595487397 2322 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3341 9147222 25.867 µM 0.0359560983408454 0.476580651670413 no 1581 0.48565868237405 2296 1939759 SGTC_378 3970-0959 8.33 µM 0.0359097475213028 0.476599042653411 no 1582 0.485677161741795 2315 6615653 SGTC_1845 st056753 3.01 µM 0.0356859806867984 0.47668782909898 no 1583 0.485766374611957 2332 5375839 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0356305707987716 0.476709814872963 no 1584 0.485788465909893 2320 688803 SGTC_2318 6029776 164 µM 0.0350676049789908 0.476933194883026 no 1585 0.48601291649903 2329 818325 SGTC_562 3772-2733 112 µM 0.0348614977880381 0.477014978265419 no 1586 0.486095091126239 2334 2876874 YIL048W NEO1 SGTC_1630 st005209 31.3 µM 0.0341380022073363 0.477302069124868 no 1587 0.486383552377671 2350 3367314 SGTC_1605 st000082 49.1 µM 0.0337563540584877 0.477453515987329 no 1588 0.486535720254335 2317 1114022 SGTC_1781 st038725 66.3 µM 0.0331048144262601 0.477712069580592 no 1589 0.486795501749414 2308 4270275 YIL048W NEO1 SGTC_380 3970-0968 6 µM 0.032137026885915 0.478096138630742 no 1590 0.487181387732664 2337 2891601 SGTC_1747 st037496 66.6 µM 0.0318917602684185 0.478193476583011 no 1591 0.487279184826099 2339 723305 SGTC_715 0868-0130 184 µM 0.0318852452630368 0.478196062184124 no 1592 0.487281782616051 2345 2876258 SGTC_1161 k007-0610 110 µM 0.0316396915145929 0.478293515426441 no 1593 0.487379694986049 2347 5843850 SGTC_1940 st075990 51.1 µM 0.0314356984913223 0.478374475395748 no 1594 0.487461035965802 2292 1084979 SGTC_2324 6149169 200 µM 0.0301783566955966 0.478873503963273 no 1595 0.487962404761783 2337 2888231 SGTC_3009 9080819 71.4286 µM 0.0289851188923182 0.479347120829086 no 1596 0.488438229506144 2320 17027216 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0285521075667952 0.479518997812081 no 1597 0.488610904559857 2346 5357218 A potent inhibitor of glutathione S-transferases. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0278313190533702 0.479805111819216 no 1598 0.488898343319932 2328 2374 Ca(2+)-ATPase inhibitor. SGTC_1704 st028805 70.8 µM 0.0268035174013168 0.480213111378021 no 1599 0.489308223873327 2322 2876101 SGTC_1426 4048-4480 71.7 µM 0.0265731110799985 0.480304577096556 no 1600 0.489400109966866 2358 14224343 SGTC_2750 bromebric acid 70.15 µM 0.0262989032604041 0.480413432298055 no 1601 0.48950946484069 2328 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3229 9132204 49.47 µM 0.0258018319906848 0.480610763697477 no 1602 0.48970770030966 2345 17682924 SGTC_2598 perillyl alcohol 100 µM 0.0257317590088471 0.480638582223523 no 1603 0.489735646106288 2336 10819 An apoptosis inducer. SGTC_2234 tolnaftate 200 µM 0.0241189231964171 0.481278893522038 no 1604 0.490378874592354 2356 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1782 st039423 80.636 µM 0.0239515428933732 0.481345347903696 no 1605 0.490445630387123 2338 2068169 SGTC_2063 5246145 200 µM 0.0222450672413816 0.482022892871054 no 1606 0.491126234006597 2351 711240 SGTC_1223 0764-0573 147 µM 0.0206919220514113 0.482639604173265 no 1607 0.491745706455511 2367 1609797 SGTC_23 0213-0011 39.996 µM 0.0206890102387731 0.482640760413573 no 1608 0.491746867852064 2355 627608 SGTC_41 0478-0632 82.643 µM 0.0202187197661167 0.482827508129841 no 1609 0.491934447361906 2377 3750424 SGTC_415 dibenzyl ketone 100 µM 0.0182413825344817 0.483612730019988 no 1610 0.492723144816136 2367 7593 SGTC_1352 1496-0991 99 µM 0.0148034232379437 0.484978130194826 no 1611 0.494094504266203 2377 3000039 SGTC_2163 5671233 125 µM 0.0146947596618573 0.485021289352817 no 1612 0.494137850046138 2376 701023 SGTC_1388 3346-4487 254 µM 0.0142469907325601 0.485199136716455 no 1613 0.49431646529984 2365 3345614 SGTC_1160 4092-0570 10.5 µM 0.0122340143831804 0.485998697763718 no 1614 0.495119456149881 2375 4994975 SGTC_2488 5268135 45.7 µM 0.0120973843089565 0.48605296976975 no 1615 0.495173959629699 2377 1270356 YLR208W SEC13 SGTC_313 3474-0040 5.03 µM 0.0115398044689619 0.48627445351756 no 1616 0.495396386264964 2386 1043375 YIL048W NEO1 SGTC_1891 st059073 26.2 µM 0.0110709399241178 0.486460700755961 no 1617 0.495583424200795 2388 688754 SGTC_501 nsc-95397 161 µM 0.0106402719116676 0.486631777774635 no 1618 0.495755225755245 2379 262093 SGTC_764 1951-2361 146 µM 0.0105601992371088 0.48666358582924 no 1619 0.495787168335959 2386 5438930 SGTC_2582 agaric acid 100 µM 0.0104981747514211 0.48668822448292 no 1620 0.495811911154136 2381 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2591 skatole 100 µM 0.0091978804940794 0.487204765913415 no 1621 0.496330628319661 2374 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1149 3909-7961 23.3 µM 0.00723224895450291 0.487985652813888 no 1622 0.497114775261833 2376 735261 SGTC_2569 tetrandrine 100 µM 0.00687422101963148 0.488127891702019 no 1623 0.497257604189075 2388 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_276 colchicine 750 µM 0.00677906462137217 0.488165696102678 no 1624 0.497295565215017 2356 2833 A microtubule depolymerizer. SGTC_1564 D-Arginine 115 µM 0.00626631245045377 0.488369407699653 no 1625 0.497500119381651 2385 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2814 7977482 42.97 µM 0.00326002160485888 0.489563837988582 no 1626 0.498699441850466 2390 6456762 SGTC_486 niguldipine 82 µM 0.00310971876221759 0.48962355740044 no 1627 0.498759403705094 2399 1236 A calcium channel blocker. SGTC_2781 5567276 71.43 µM 0.00290616824574229 0.489704433933541 no 1628 0.498840608244815 2398 2853274 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.00211713571899392 0.490017943447672 no 1629 0.499155385679309 2396 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2478 5763493 32.33 µM 0.00211542992679886 0.490018621223797 no 1630 0.499156066190414 2399 1365576 YLR208W SEC13 SGTC_1350 1495-0454 146 µM 0.00169313540113617 0.490186415784248 no 1631 0.499324537024768 2402 1069057 SGTC_1093 fluphenazine 7.97 µM 0.00167952596452727 0.490191823388566 no 1632 0.499329966396724 2403 6602611 An atypical antipsychotic. SGTC_3078 9116413 49.47 µM 0.00127584477484146 0.490352223800829 no 1633 0.499491011714173 2401 17177322 SGTC_1214 0358-0031 63.7 µM 0.000947492869075194 0.49048269370477 no 1634 0.499622005090704 2403 4301366 SGTC_2766 oltipraz 83.91 µM 0.000838868119196355 0.490525855733868 no 1635 0.499665340078822 2404 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2800 7887935 81.82 µM 0.00066904793375433 0.490593333982791 no 1636 0.499733088511523 2403 2961002 SGTC_1548 st061468 90.8 µM 0.000532949191929528 0.490647413171159 no 1637 0.499787384044099 2402 390799 SGTC_2102 5377816 72.7585 µM 0 0.490859183561546 no 1638 0.5 2406 1379702 SGTC_1314 1222-0010 41.1 µM -0.000285646948557315 0.490972688064403 no 1639 0.499886043356503 2408 3526027 SGTC_980 1473-0395 201 µM -0.000420858805710869 0.491026416023611 no 1640 0.499832101633279 2408 768876 SGTC_2350 9023895 38.85 µM -0.00065128547979781 0.491117979040801 no 1641 0.499740174703866 2409 2997209 SGTC_1822 st052468 42 µM -0.000818845164063363 0.491184561341225 no 1642 0.499673328079459 2408 2873678 SGTC_408 cantharidin 100 µM -0.00210561500643114 0.491695886277197 no 1643 0.499159981768406 2413 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1053 3366-3204 134 µM -0.00242315789882817 0.491822070725089 no 1644 0.499033300808096 2410 3632071 YPR165W RHO1 SGTC_3355 9151058 44.0485 µM -0.00259488499521046 0.491890311576612 no 1645 0.498964791824381 2410 17015728 SGTC_1978 st071761 42 µM -0.00267641250078613 0.491922709030537 no 1646 0.498932267168369 2411 5147680 SGTC_2010 4012422 159 µM -0.0037485879438981 0.492348775692618 no 1647 0.498504533279738 2421 952393 SGTC_867 0518-0118 155 µM -0.00434031918321224 0.492583924703946 no 1648 0.498268468603919 2417 6848158 SGTC_109 0132-0036 33.701 µM -0.00472412403706108 0.492736446903734 no 1649 0.498115354193808 2411 67274 A color developer. SGTC_2366 9070441 60.58 µM -0.00509684605972098 0.492884565856381 no 1650 0.497966661413708 2417 6837235 SGTC_1231 0242-0792 125 µM -0.00548488496510613 0.493038772748274 no 1651 0.497811858455615 2411 3707635 SGTC_198 3454-2873 16.191 µM -0.00569057911066814 0.493120516147465 no 1652 0.497729799645325 2412 710957 SGTC_998 3996-0085 177 µM -0.00629943767285894 0.493362479835483 no 1653 0.497486904590713 2419 715391 SGTC_1447 4239-0816 81.9 µM -0.00661039904074769 0.493486058513882 no 1654 0.497362851538412 2422 1341554 SGTC_1442 4112-3290 3 µM -0.00670642708207838 0.493524220996813 no 1655 0.497324542741846 2415 704353 SGTC_1030 k029-0042 36.7 µM -0.00774431212195616 0.493936690372996 no 1656 0.496910497343787 2424 6080581 SGTC_2031 5180455 200 µM -0.00804292971592998 0.494055366213272 no 1657 0.496791369871751 2421 29949 SGTC_1817 st052116 64.4 µM -0.00880221183085508 0.494357120514318 no 1658 0.496488470884602 2420 4361398 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.00915800488788229 0.494498521101378 no 1659 0.496346535714937 2436 616764 SGTC_3210 9128157 49.47 µM -0.00983774155905814 0.494768666459376 no 1660 0.496075372253535 2453 17590849 SGTC_145 3737-0113 38.366 µM -0.0107673879652397 0.495138136425344 no 1661 0.495704516691994 2430 6849351 SGTC_1217 1183-1422 255 µM -0.0111303857998204 0.495282404036611 no 1662 0.495559710188706 2442 2849664 SGTC_1340 1486-1359 257 µM -0.0121662598817817 0.49569409874486 no 1663 0.495146484273619 2449 4309068 SGTC_591 4299-0174 154 µM -0.0132281609480298 0.496116142296648 no 1664 0.49472288120843 2449 5509088 SGTC_3309 9129340 25.759 µM -0.0133701150884983 0.496172561102784 no 1665 0.49466625470787 2450 17158987 SGTC_76 0433-0009 400.328 µM -0.013379244903929 0.496176189694798 no 1666 0.494662612764236 2484 2841569 SGTC_89 0302-0250 142.109 µM -0.0137639719778899 0.496329097515329 no 1667 0.494509143003302 2427 4203518 YLR208W SEC13 SGTC_1201 1889-3372 45.9 µM -0.0137777620856459 0.496334578333727 no 1668 0.494503642067881 2446 5392199 SGTC_1856 st057054 55.7 µM -0.0158595911533807 0.497161999592435 no 1669 0.493673203766439 2441 1266018 SGTC_2148 5546263 113.568 µM -0.0160371081410625 0.497232554188981 no 1670 0.493602393740488 2442 792097 SGTC_2313 7726885 200 µM -0.0166135291590438 0.497461654833538 no 1671 0.493372465670086 2449 726423 SGTC_171 k064-0041 9.68 µM -0.0174825745561439 0.497807061667528 no 1672 0.49302581710645 2432 53325 SGTC_747 3448-8087 38.7 µM -0.0185979156026563 0.49825036242394 no 1673 0.492580932828768 2461 5168703 SGTC_2513 baicalein 25.65 µM -0.018941286832323 0.498386838383262 no 1674 0.492443971655747 2458 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_990 3985-0011 41.3 µM -0.0201311901759838 0.498859777444475 no 1675 0.491969359510337 2469 5399565 YGL099W LSG1 SGTC_1046 2001-0062 216 µM -0.0213301888222803 0.499336333144426 no 1676 0.491491131057952 2448 739778 SGTC_1803 st050068 52.4 µM -0.0225893779441316 0.499836813243305 no 1677 0.490988908419931 2427 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_585 0kpi-0023 191 µM -0.0226486870952289 0.499860386402439 no 1678 0.490965253543882 2446 64601 SGTC_2821 7996764 71.43 µM -0.0233512118164599 0.499860386402439 no 1679 0.490685060855759 2454 2987135 SGTC_776 4476-4378 112 µM -0.0237188503843228 0.499714263896062 no 1680 0.49053843490147 2507 2892008 SGTC_1729 st035615 45.989 µM -0.0237378839198406 0.499706698782288 no 1681 0.490530843756749 2530 17385451 SGTC_1148 3909-7663 27.7 µM -0.0239237035915033 0.499632842464698 no 1682 0.490456733480149 2515 4084526 SGTC_1865 st057639 52.2 µM -0.0239821876598008 0.49960959725378 no 1683 0.490433408404845 2453 688818 SGTC_624 k048-0052 28 µM -0.0248803789165716 0.499252600326159 no 1684 0.490075188873024 2468 6835531 SGTC_3275 9138069 49.47 µM -0.0251988794206536 0.499126008595606 no 1685 0.489948165383181 2520 17617007 SGTC_209 4077-0173 175.592 µM -0.0254106657344247 0.499041831709355 no 1686 0.489863701915005 2503 15993494 SGTC_2673 kobusone 100 µM -0.0270082652143103 0.498406849210303 no 1687 0.4892265708748 2463 6710676 An epoxy ketone and protein crosslinker. SGTC_2980 9014342 25.29 µM -0.02785408055242 0.498070672655092 no 1688 0.488889266314597 2560 2996599 SGTC_1571 st070080 73.4 µM -0.02803119276034 0.498000278055619 no 1689 0.488818636345578 2473 4315245 SGTC_989 1501-0895 10.3 µM -0.0283690541602166 0.497865992636832 no 1690 0.488683902732793 2452 2830112 SGTC_2344 7990960 76.95 µM -0.0287290169006537 0.497722923149288 no 1691 0.488540356887296 2476 140813 SGTC_2625 euphol 100 µM -0.028814968972303 0.497688760992709 no 1692 0.488506081161969 2470 6708538 A triterpene alcohol. SGTC_1554 st069299 38.7 µM -0.0288803554891204 0.497662772748233 no 1693 0.488480006567582 2483 24207999 SGTC_2025 5147754 141 µM -0.0290527722883161 0.497594244754715 no 1694 0.488411251067725 2476 315777 YLR208W SEC13 SGTC_282 k297-0036 65.7 µM -0.0302140710818824 0.497132682190249 no 1695 0.48794816327733 2462 5061378 SGTC_2376 9072922 81.32 µM -0.0314080273106827 0.496658143813234 no 1696 0.487472069721365 2548 17087968 SGTC_2295 7971645 200 µM -0.0317403807383312 0.496526050624091 no 1697 0.487339545962595 2498 2978226 YKL099C UTP11 SGTC_1119 parthenolide 318.541 nM -0.0318913340610642 0.496466054660044 no 1698 0.487279354771788 2573 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2989 9073649 71.4286 µM -0.0323726720940639 0.49627474878332 no 1699 0.487087427785696 2463 21367202 SGTC_162 k030-0015 37.8 µM -0.0326025831016154 0.496183371872219 no 1700 0.486995754954882 2486 1809920 YMR134W ERG29 SGTC_2911 7942208 15.64 µM -0.0328343985965618 0.49609123823545 no 1701 0.486903323440098 2483 1243384 SGTC_1283 0922-0125 16.4 µM -0.0339779623027983 0.495636739048418 no 1702 0.486447362043452 2488 3360884 SGTC_2499 avocadenofuran 51.48 µM -0.0356489137232276 0.4949726446688 no 1703 0.485781152787788 2477 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1433 4060-0023 7.6 µM -0.0361783076542112 0.494762247873425 no 1704 0.485570091324304 2511 3840627 SGTC_1860 st056228 74.6 µM -0.037778689108022 0.49412621808116 no 1705 0.484932067934379 2568 688679 SGTC_471 1-acyl-paf 4 µM -0.0385039123726673 0.493838001863319 no 1706 0.484642956088217 2466 16759367 SGTC_208 k072-0098 12.366 µM -0.0395954641236372 0.493404206506718 no 1707 0.484207821854944 2491 5948901 SGTC_3190 9110366 49.47 µM -0.0397508430589028 0.493342457733599 no 1708 0.484145883391735 2474 17123768 SGTC_2335 9018011 154.17 µM -0.0407790616597249 0.492933839915454 no 1709 0.483736015923292 2537 6458208 SGTC_2443 5493264 126.67 µM -0.0411781040658127 0.492775260982978 no 1710 0.483576954644336 2516 5340055 SGTC_3194 9111903 49.47 µM -0.0416331500984701 0.492594427677069 no 1711 0.483395573093223 2546 17087251 SGTC_465 cgp-37157 41 µM -0.0422507263399348 0.492349008017506 no 1712 0.483149412432118 2475 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2447 5741742 33.78 µM -0.0422555252561005 0.492347100979372 no 1713 0.483147499649792 2520 1776504 SGTC_657 3534-0529 86.7 µM -0.0428630413746091 0.492105681976706 no 1714 0.482905355184386 2500 1049549 SGTC_688 0527-0193 473 µM -0.0446051956434184 0.491413388874087 no 1715 0.482211000629571 2519 4007154 SGTC_458 nppb 133 µM -0.0447285922013502 0.491364354800973 no 1716 0.48216182160917 2496 4549 A chloride channel blocker. SGTC_2670 beta-carotene 100 µM -0.0448638113599747 0.49131062293254 no 1717 0.482107931067917 2490 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2987 9018338 71.43 µM -0.0449694166112815 0.491268658815138 no 1718 0.482065843145817 2465 5055682 SGTC_2412 st077135 33.4 µM -0.045056852911126 0.491233914525572 no 1719 0.482030996429766 2724 13258915 SGTC_1476 4112-3294 3.34 µM -0.0453079923992839 0.491134120381794 no 1720 0.481930908484416 2572 704369 SGTC_1633 st005664 67.9 µM -0.0454106285217711 0.491093336497066 no 1721 0.481890004696427 2488 2063822 SGTC_1411 3909-8223 150 µM -0.0459167625823425 0.490892218488342 no 1722 0.481688296829837 2492 X1411 SGTC_1790 st045711 43.5 µM -0.0460508516897988 0.490838937073241 no 1723 0.481634859542301 2496 585119 SGTC_1131 3454-3128 32.3 µM -0.046238258771454 0.490764469594517 no 1724 0.481560174490421 2638 710982 SGTC_1821 st053465 65.6 µM -0.0463479682780829 0.490720875924979 no 1725 0.48151645360287 2524 675086 SGTC_1409 3909-8004 61.9 µM -0.0470166587224163 0.490455170553399 no 1726 0.481249975235278 2514 2119279 SGTC_2463 5473429 200 µM -0.0474911623818885 0.490266628218307 no 1727 0.481060886893684 2557 5399405 SGTC_1484 3473-2379 286 µM -0.0481291940823559 0.490013112035827 no 1728 0.480806639823203 2485 671917 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.0484079978151503 0.489902333130005 no 1729 0.480695542722228 2574 94937 An inhibitor of serotonin biosynthesis. SGTC_2882 9058044 58.44 µM -0.0490481473071121 0.489647981317995 no 1730 0.480440463042084 2536 18076804 SGTC_2361 9034121 116 µM -0.049418631393177 0.489500778089873 no 1731 0.480292840298592 2525 6496917 SGTC_1932 st074806 40.9 µM -0.0495624719077412 0.48944362679378 no 1732 0.480235526468547 2684 17251235 SGTC_2741 miltefosine 3.04 µM -0.0498310367854536 0.489336920089378 no 1733 0.480128516810225 2511 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1521 st012942 49.4 µM -0.0502752570948304 0.489160423316036 no 1734 0.47995152040348 2664 24207259 SGTC_295 k015-0027 31 µM -0.0517780217014691 0.488563363663774 no 1735 0.479352784098492 2548 3887424 SGTC_2787 5284540 71.43 µM -0.0521145177817032 0.488429674711151 no 1736 0.4792187225844 2536 736958 SGTC_2603 homopterocarpin 100 µM -0.0529349127878396 0.48810373954583 no 1737 0.478891883499379 2549 101795 A weak amylase inhibitor. SGTC_1239 0337-0584 35.4 µM -0.0549394388525712 0.487307394189784 no 1738 0.47809335582461 2568 914301 YML130C ERO1 SGTC_2001 4023502 57.655 µM -0.0549656780801007 0.487296970365114 no 1739 0.478082903680871 2561 108941 YCR052W RSC6 SGTC_1999 st074831 12.5 µM -0.0551007067320926 0.487243328870255 no 1740 0.478029116555519 2520 17112523 SGTC_1141 3253-0389 52.6 µM -0.0558104851404354 0.486961366051315 no 1741 0.477746391015246 2486 5402031 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0565601170460141 0.486663578322503 no 1742 0.47744780282231 2510 140250 A respiratory chain inhibitor. SGTC_2275 7947463 200 µM -0.0573625965903406 0.486344805364415 no 1743 0.47712817875782 2490 1225414 SGTC_538 2922-0838 53.3 µM -0.0577530740695951 0.486189697187814 no 1744 0.476972658607961 2507 777039 SGTC_52 0329-0193 875 nM -0.057828027478208 0.4861599239125 no 1745 0.476942806415253 2681 3739292 SGTC_2942 9052777 62.25 µM -0.0581079192031841 0.486048744950431 no 1746 0.476831333220919 2524 6469503 SGTC_1762 st045503 25.4615 µM -0.0582937342993988 0.485974935829953 no 1747 0.476757329167315 2552 4645554 SGTC_421 streptovitacin 30 mM -0.0599529870570073 0.485315872189841 no 1748 0.476096539093531 2701 91467 include heat shock SGTC_950 1165-0508 94.1 µM -0.0601703882685432 0.48522952225549 no 1749 0.476009964853752 2555 6148369 SGTC_1879 gemcitabine 100 µM -0.0610013304573277 0.484899485418588 no 1750 0.475679074739503 2523 60750 A nucleoside analog which inhibits DNA replication. SGTC_2332 7982454 138.89 µM -0.0613331539284624 0.484767693364671 no 1751 0.475546943738733 2491 2981748 SGTC_1557 sumaresinolic acid 42.3 µM -0.0624908445372721 0.48430790048728 no 1752 0.475085976346145 2492 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_13 0199-0087 65 µM -0.0627360264169347 0.484210525760935 no 1753 0.474988354476335 2517 4589825 SGTC_2877 9040724 71.43 µM -0.063041284196266 0.484089293025694 no 1754 0.474866814823632 2525 6463895 SGTC_1280 0880-0253 10.1 µM -0.0639687145458033 0.48372097432214 no 1755 0.474497568972487 2548 6836607 SGTC_510 ag-490 170 µM -0.0642589863350812 0.483605698931548 no 1756 0.474382005045313 2516 5328779 SGTC_1700 st030840 7.9285 µM -0.0659642282015332 0.482928525656078 no 1757 0.473703152579579 2613 5499307 SGTC_3183 9108214 49.47 µM -0.0663373085919396 0.48278037717649 no 1758 0.473554640333616 2515 4974831 SGTC_893 0958-0369 48.9 µM -0.0667232348630963 0.482627130159693 no 1759 0.473401018391021 2669 6819948 SGTC_742 0kpi-0133 140 µM -0.0675980630024232 0.482279755204386 no 1760 0.473052798687148 2595 2728852 SGTC_1434 4073-0095 163 µM -0.0692990403351295 0.481604373373437 no 1761 0.47237579480236 2538 24133745 SGTC_1224 0823-0416 294 µM -0.0701469100014561 0.481267741940717 no 1762 0.472038364924654 2604 3598164 SGTC_1998 st075797 76.8 µM -0.0702253717765946 0.48123659077274 no 1763 0.472007140207907 2507 24208315 SGTC_2977 9011197 71.43 µM -0.0705310664966419 0.481115223881933 no 1764 0.471885487312128 2718 2704722 SGTC_2817 7995342 71.43 µM -0.0708395110833774 0.480992767013411 no 1765 0.471762742750231 2533 18879975 SGTC_1701 st028638 40.4 µM -0.0721490199121137 0.480472893575992 no 1766 0.471241657796887 2538 3490878 SGTC_85 0868-0259 160.055 µM -0.0732131264372245 0.480050468977141 no 1767 0.47081826051746 2611 83173 SGTC_2166 5933061 31.504 µM -0.0734738231169636 0.479946982087968 no 1768 0.470714536943666 2816 2877375 SGTC_67 0335-0847 266 µM -0.0755347066135261 0.479128936104007 no 1769 0.469894642258133 2836 4552207 YOR254C SEC63 SGTC_2257 7960413 200 µM -0.0772033999930292 0.478466630099743 no 1770 0.469230868459328 2585 2974689 YIL048W NEO1 SGTC_616 4092-0450 108 µM -0.0782093164087694 0.478067409516523 no 1771 0.468830775648486 2596 787165 SGTC_2038 4100038 30.985 µM -0.0786470893870496 0.4778936763003 no 1772 0.468656665797254 2616 3596803 SGTC_154 3389-1638 511.116 µM -0.0792554670951122 0.477652244406814 no 1773 0.468414713468351 2643 5238686 SGTC_845 0330-0138 4.51 µM -0.0796510404497919 0.477495267336122 no 1774 0.468257399863866 2526 9039800 SGTC_2357 9067248 200 µM -0.0798706219487757 0.477408131373759 no 1775 0.468170077724901 2608 9150235 SGTC_2301 7769476 200 µM -0.0817035777265362 0.476680806774469 no 1776 0.467441216629977 2603 977820 SGTC_2253 7938677 135.83 µM -0.0818182910397184 0.476635290604659 no 1777 0.467395605346616 2705 2301972 SGTC_1015 4130-4525 82 µM -0.0820036627907044 0.476561739088085 no 1778 0.467321900391178 2569 1363237 SGTC_1248 0469-0687 58.6 µM -0.0824567250931725 0.476381977094481 no 1779 0.467141764736352 2619 4017482 SGTC_959 1222-0044 107 µM -0.0828855546187094 0.476211834391686 no 1780 0.466971270129631 2569 6083612 SGTC_919 tnp00227 403.569 nM -0.0844736106974693 0.475581794161757 no 1781 0.466339941722977 2599 1269246 A methoxyflavone. YNL221C POP1 SGTC_2692 st077426 47.7 µM -0.0866017920114781 0.474737562397873 no 1782 0.465494020717532 2584 25238571 SGTC_1186 1319-0216 26 µM -0.0869601093977451 0.474595431934032 no 1783 0.465351610016728 2682 4565136 SGTC_698 k064-0052 127 µM -0.0871748732523065 0.474510245078552 no 1784 0.465266255773426 2538 5088751 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0874326630115675 0.474407993382517 no 1785 0.465163803726298 2554 77254 SGTC_1715 st032160 10.2275 µM -0.087772535157178 0.474273186480331 no 1786 0.465028733632245 2607 5289825 SGTC_1126 isoteolin 1.0172 µM -0.0878336509975264 0.474248945802859 no 1787 0.46500444574253 2575 133323 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0878569415651529 0.474239707975126 no 1788 0.464995189931956 2560 6708561 SGTC_2178 5812956 200 µM -0.0886951653799303 0.473907249286175 no 1789 0.46466208743082 2530 5403383 SGTC_266 formosanin C 406 nM -0.0891291079886722 0.47373514487128 no 1790 0.464489652308641 2570 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1296 1068-0102 11.9 µM -0.0892216424688391 0.473698445737465 no 1791 0.464452882882948 2649 767053 SGTC_118 0083-0097 135.343 µM -0.0892915891003163 0.473670705082547 no 1792 0.464425089147862 2587 5207356 SGTC_3290 9121031 71.43 µM -0.0945099423805931 0.471601488894056 no 1793 0.462352042460274 2602 17014854 SGTC_2310 7668677 200 µM -0.0947242417221394 0.471516529492816 no 1794 0.462266931221042 2670 2197143 SGTC_2333 9017922 200 µM -0.0954462017992128 0.471230316542206 no 1795 0.461980209914101 2686 3163164 SGTC_2623 humulene 100 µM -0.0958407562478352 0.471073906139374 no 1796 0.461823523762078 2625 6187145 An anti-inflammatory. SGTC_643 k048-0106 28.4 µM -0.0970873418118642 0.470579760557101 no 1797 0.461328516570797 2686 6763920 SGTC_725 1497-0963 19 µM -0.0971041185605298 0.470573110573729 no 1798 0.46132185509137 2613 3549977 SGTC_953 1188-0045 9.7 µM -0.0971955291230425 0.470536877313441 no 1799 0.461285559239627 2673 6144426 SGTC_2998 9066762 71.4286 µM -0.0973188006007812 0.470488015430282 no 1800 0.461236613073316 2668 4945196 SGTC_2654 protoveratrine a 100 µM -0.0977063295330684 0.470334411071944 no 1801 0.461082744684276 2576 5702278 A heart drug and vasodilator. SGTC_1114 scopoletin 1.73284 µM -0.0987825325416986 0.469907861051677 no 1802 0.460655468832499 2574 5280460 A coumarin with genotoxic properties. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0992603562687475 0.469718488007884 no 1803 0.460465777017911 2612 5357218 A potent inhibitor of glutathione S-transferases. SGTC_303 1348-1668 34.2 µM -0.0995266390130805 0.469612956716489 no 1804 0.460360069012928 2611 5380509 SGTC_3345 9148410 3.559 µM -0.0997751273411042 0.469514479507343 no 1805 0.460261427500682 2615 4903596 SGTC_334 1502-1024 68.5 µM -0.103739922771045 0.467943466874068 no 1806 0.458687871886052 2681 3296216 SGTC_788 1182-0090 188 µM -0.104337109121984 0.467706880091593 no 1807 0.458450914894125 2807 5715185 SGTC_972 1319-0219 195 µM -0.105767675114322 0.467140180589381 no 1808 0.457883342207277 2650 23903702 SGTC_838 0109-0203 71.4 µM -0.106206821616884 0.466966231908125 no 1809 0.457709129346967 2600 759422 SGTC_743 1275-0778 158 µM -0.108780763956646 0.465946805154306 no 1810 0.456688190702213 2696 2849257 YMR203W TOM40 SGTC_1558 st069300 45.6 µM -0.109082533587189 0.465827301814304 no 1811 0.456568514195587 2606 24208000 SGTC_87 0100-0052 35.5 µM -0.109160071396313 0.465796596679644 no 1812 0.456537764705417 2622 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_448 monastrol 171 µM -0.109695941502068 0.465584396572389 no 1813 0.45632525960238 2635 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_122 0236-0016 402.397 µM -0.110265955346061 0.465358686570217 no 1814 0.456099228141469 2617 6808838 SGTC_174 3553-0389 74.3 µM -0.111329616610941 0.464937535450909 no 1815 0.455677485360394 2718 738071 SGTC_418 lividomycin a 100 µM -0.112223998852592 0.464583439852405 no 1816 0.455322900515663 2611 72394 An antibiotic. SGTC_2948 9070189 9.45 µM -0.113421495862269 0.464109381804877 no 1817 0.45484819922057 2671 6473636 YDL196W YDL196W SGTC_1680 diphenhydramine 100 µM -0.113710578853325 0.463994948945551 no 1818 0.454733613103538 2682 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2830 7992007 71.43 µM -0.113968329752459 0.46389292133663 no 1819 0.45463144951225 2561 1952075 SGTC_930 2810-3379 265 µM -0.114579998606006 0.463650809056669 no 1820 0.454389017040108 2762 1015764 SGTC_2520 obtusaquinone 4.71 µM -0.114817847296744 0.463556666829139 no 1821 0.454294751258041 2728 5967872 SGTC_1896 st058441 89 µM -0.11631278451825 0.46296500682591 no 1822 0.453702326901579 2643 688759 SGTC_2250 alverine citrate 130 µM -0.117239919749573 0.462598110193605 no 1823 0.453334966822559 2578 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_995 3931-2021 34.6 µM -0.117245538417022 0.462595886806491 no 1824 0.453332740651569 2701 730143 SGTC_1716 st033144 30.6155 µM -0.118013363276462 0.46229205854323 no 1825 0.453028534756594 2667 674617 SGTC_574 1315-0397 40 µM -0.118185537453098 0.462223932242581 no 1826 0.452960324540838 2614 6794277 SGTC_702 1488-0190 94 µM -0.118900160700461 0.461941180230632 no 1827 0.452677227222569 2684 949357 SGTC_1988 st071872 53.4 µM -0.12011783173329 0.461459433775326 no 1828 0.452194903491603 2610 16414116 SGTC_2608 thymoquinone 42.66 µM -0.120323873740947 0.461377923074522 no 1829 0.452113296494509 2589 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2588 indole-3-carbinol 100 µM -0.12081086446378 0.4611852748591 no 1830 0.451920422270944 2717 3712 Induces cell cycle arrest. SGTC_14 0354-0009 295 µM -0.121397581774807 0.460953187994802 no 1831 0.451688066089897 2591 1713507 SGTC_560 2332-1943 155 µM -0.121889572143899 0.460758582369679 no 1832 0.451493237135201 2612 21177716 SGTC_179 1273-0063 6.77 µM -0.122831290423907 0.460386114183759 no 1833 0.451120347848584 2637 3108139 SGTC_1985 st071382 65.5 µM -0.122905290142357 0.460356847301679 no 1834 0.451091048231514 2624 6123237 SGTC_2795 7780010 54.55 µM -0.122935545826914 0.460344881242969 no 1835 0.451079068803598 2735 953673 SGTC_1689 st020265 53.493 µM -0.12358843110113 0.460086675276426 no 1836 0.450820576449923 2699 5758320 YPR016C TIF6 SGTC_1066 ketoconazole 628 nM -0.124221404149083 0.459836360353287 no 1837 0.450569987717509 2757 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_144 4161-2749 112.381 µM -0.1247338361795 0.459633726122383 no 1838 0.450367134592368 2614 797501 YMR168C CEP3 SGTC_758 0868-0029 16 µM -0.125355574435654 0.459387882324554 no 1839 0.450121028538599 2747 762687 SGTC_2108 5365811 200 µM -0.126291963039794 0.459017650817137 no 1840 0.449750408943615 2715 780283 SGTC_733 4069-0007 56.1 µM -0.126513736141128 0.458929970845632 no 1841 0.449662638271195 2634 5717425 YNL287W SEC21 SGTC_1664 st014217 9.02 µM -0.126747333916241 0.45883761804461 no 1842 0.449570190435694 2644 3982782 SGTC_1103 duloxetine 36.1 µM -0.128131037986766 0.458290616831314 no 1843 0.449022636862933 2796 60835 A selective serotonin reuptake inhibitor. SGTC_522 1273-0010 11.6 µM -0.130389981069604 0.45739778926828 no 1844 0.448128946434321 2874 5705015 SGTC_567 1080-0542 68.4 µM -0.132581839954079 0.456531681586285 no 1845 0.44726204761647 2637 5950415 SGTC_726 3448-4391 34.2 µM -0.134240385912653 0.455876448205282 no 1846 0.446606245782711 2784 1356692 SGTC_817 1391-0715 46 µM -0.136059036964248 0.455158100893776 no 1847 0.445887305042875 2711 1353946 SGTC_2970 9090938 41.86 µM -0.136327302780149 0.455052151175882 no 1848 0.44578127043678 2723 17217104 SGTC_383 2324-0395 7.37 µM -0.13708311478347 0.454753665700041 no 1849 0.445482549457279 2773 3146421 SGTC_1127 asiatic acid 681.4 nM -0.138676290120844 0.454124572352932 no 1850 0.444852977391365 2649 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2914 7968218 45.32 µM -0.138721196482006 0.454106841945231 no 1851 0.44483523383808 2742 2977111 SGTC_2929 9013348 24.6 µM -0.13900881916661 0.453993281864418 no 1852 0.44472159001295 2746 2995952 SGTC_12 0849-0099 9.267 µM -0.139819191465138 0.453673348415113 no 1853 0.444401424824212 2618 6071388 SGTC_2225 6654152 15.4 µM -0.140739274622124 0.453310137779539 no 1854 0.444037958607197 2650 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1293 1000-1278 195 µM -0.14211008423559 0.452769071576669 no 1855 0.443496526476364 2760 678847 SGTC_2827 7993847 71.43 µM -0.142926233065442 0.452446974658782 no 1856 0.443174220137992 2745 2985692 SGTC_3278 9139605 49.47 µM -0.143247101776777 0.452320350892594 no 1857 0.443047515764413 2880 7958859 SGTC_1446 4239-0190 62 µM -0.14400693244591 0.45202051982432 no 1858 0.442747497699897 2682 1340085 SGTC_342 k048-0088 23.3 µM -0.144568279573546 0.451799028419368 no 1859 0.442525871655392 2632 6820570 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.144986246174253 0.451634120579964 no 1860 0.442360865503325 2695 390807 SGTC_615 k087-0205 167 µM -0.145231476469312 0.451537369367971 no 1861 0.442264057378742 2674 9642773 SGTC_1739 st037196 92.5 µM -0.147680829605769 0.45057117993837 no 1862 0.441297330742817 2754 612214 SGTC_1568 digitonin 820 nM -0.150046831893392 0.449638147676979 no 1863 0.440363833480682 2730 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1983 st071813 46.9 µM -0.150939536564659 0.44928618191717 no 1864 0.440011706044037 2734 11838595 SGTC_900 1112-0045 141 µM -0.151143637410238 0.449205716879049 no 1865 0.439931205101139 2703 56211 YIL048W NEO1 SGTC_2883 9059145 45.46 µM -0.151729856793276 0.448974616455623 no 1866 0.439700003745119 2647 16476510 SGTC_119 0121-0043 24.815 µM -0.152639680566722 0.448615978456078 no 1867 0.43934121554004 2663 1092378 SGTC_2733 amorolfine 100 µM -0.152782224381423 0.448559793757946 no 1868 0.4392850080191 2687 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1933 st074711 15.9 µM -0.153086854473762 0.448439725015266 no 1869 0.43916489114677 2644 17250958 SGTC_2534 helenine 20.12 µM -0.15329104527856 0.448359246662523 no 1870 0.439084381025043 2687 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2264 7948757 110.76 µM -0.154497460883807 0.447883801832855 no 1871 0.438608756552529 2660 2971411 SGTC_2556 citropten 84.59 µM -0.155136171047312 0.447632118307583 no 1872 0.43835698349908 2678 2775 A potential DNA crosslinker. SGTC_601 0986-0029 62.9 µM -0.156289196492325 0.447177822470347 no 1873 0.437902535823682 2699 24747981 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.157058690644542 0.446874677749039 no 1874 0.437599296774933 2739 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1714 st033236 13.627 µM -0.159789244783379 0.44579921876051 no 1875 0.436523548319411 2820 2916566 SGTC_2429 5902844 64.44 µM -0.160581498356836 0.445487255182699 no 1876 0.436211513970704 2837 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2072 5231554 129 µM -0.161521214184967 0.445117269559048 no 1877 0.435841452110895 2784 789545 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.16157949674906 0.445094324075039 no 1878 0.435818502174055 2684 97141 SGTC_1269 0831-0796 3.05 µM -0.161828411333831 0.44499633001819 no 1879 0.435720489462062 2789 927758 SGTC_740 k014-0057 261 µM -0.16279834631241 0.444614512825445 no 1880 0.435338605175097 2805 4012779 SGTC_2406 ethylparaben 405.7 µM -0.162802589333383 0.44461284266286 no 1881 0.43533693473858 2681 8434 A possible steroid mimic. SGTC_261 5-fluorouridine 15.376 µM -0.163434955545007 0.444363938008726 no 1882 0.435087991164984 2895 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1966 st070145 16.1 µM -0.163946126030086 0.444162753041698 no 1883 0.434886777505806 2674 3748532 SGTC_2439 5492030 7.2 µM -0.164344746054798 0.444005875333361 no 1884 0.434729879140279 2794 5722370 SGTC_909 3448-9333 149 µM -0.165326530073035 0.443619529732924 no 1885 0.434343489080265 2692 3344074 SGTC_245 methotrexate 289.6 µM -0.165680983990688 0.443480060355653 no 1886 0.434204005894769 2764 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3177 9107506 49.47 µM -0.166439307818366 0.443181701089991 no 1887 0.433905621083885 2780 8897194 SGTC_2777 climbazole 1.536 µM -0.166619710529513 0.443110727151877 no 1888 0.433834641870651 2721 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2533 agelasine 13.65 µM -0.167385982925275 0.442809281044801 no 1889 0.433533176792577 2827 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2118 5526350 200 µM -0.168098936096401 0.442528840065625 no 1890 0.433252723156938 2850 743594 SGTC_480 am 92016 50 µM -0.168182573267485 0.442495943169192 no 1891 0.433219825091285 2759 2129 K+ channel blocker. SGTC_2012 4023501 200 µM -0.168373455878463 0.442420865053026 no 1892 0.433144744554807 2769 3477460 SGTC_2850 9015429 58.44 µM -0.168443493727516 0.442393318223167 no 1893 0.43311719692344 2765 6457570 SGTC_1298 1079-1278 263 µM -0.169692232683913 0.441902219241026 no 1894 0.432626091449782 2736 2840950 SGTC_2773 thioridazine 9.09 µM -0.171323027436132 0.441261001462356 no 1895 0.431984887432308 2680 5452 An antipsychotic. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.171663785718825 0.441127036932838 no 1896 0.431850928959785 2717 688664 SGTC_1696 st025591 34.7925 µM -0.172576144382281 0.44076838861521 no 1897 0.431492302273616 2726 2787147 SGTC_2725 haloperidol 53.21 µM -0.17273669986842 0.440705279249552 no 1898 0.431429197530399 2718 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3093 9117344 49.47 µM -0.17297205354327 0.440612771765587 no 1899 0.431336697263592 2862 24824913 SGTC_1706 st031321 9.9705 µM -0.173378965665316 0.440452839627204 no 1900 0.431176778840855 2819 6103185 SGTC_1259 0671-0132 43 µM -0.174331100880705 0.440078651812115 no 1901 0.430802629246801 2743 X1259 SGTC_2327 6189656 200 µM -0.17437720918216 0.440060532669595 no 1902 0.430784512173141 2821 5349088 SGTC_376 3970-0862 59.1 µM -0.176575978986214 0.43919663024919 no 1903 0.429920731784231 2827 3135186 SGTC_2175 5807670 165.306 µM -0.176757311455253 0.43912539711402 no 1904 0.429849510756683 2783 241186 SGTC_3096 9117468 49.47 µM -0.177298068474625 0.438912982349327 no 1905 0.429637133947442 2837 41316311 SGTC_449 xestospongin c 11.1929 µM -0.178470509302742 0.438452496366222 no 1906 0.429176739768247 2850 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_115 0527-0192 112.043 µM -0.178804665740958 0.438321268847015 no 1907 0.429045540797749 2798 4233931 SGTC_1251 0490-5699 265 µM -0.179137981668175 0.438190378163033 no 1908 0.428914679644066 2818 3883818 SGTC_1330 1469-0054 61.8 µM -0.180344944602703 0.437716469474076 no 1909 0.428440886688749 2885 7102664 SGTC_922 1866-0035 480 µM -0.18140446014687 0.437300528955191 no 1910 0.428025059134443 2735 3156169 SGTC_297 0986-0032 24 µM -0.182651693243163 0.436810983825282 no 1911 0.427535660604288 2708 2847425 SGTC_1930 st074634 34.3 µM -0.182964082298544 0.436688384705174 no 1912 0.427413100508897 2714 684253 YOR116C RPO31 SGTC_2495 cafestol 54.53 µM -0.183063842024277 0.436649234631304 no 1913 0.427373963091999 2939 16667697 An anti-infammatory. SGTC_1342 1486-1464 234 µM -0.183796983450073 0.436361536973419 no 1914 0.427086361341809 2740 3253938 SGTC_1961 st076550 68.7 µM -0.184756996388477 0.435984861845973 no 1915 0.426709819495339 2862 1579337 SGTC_723 4182-0001 115 µM -0.184996893955237 0.435890743577762 no 1916 0.426615735895302 2754 744821 YLR208W SEC13 SGTC_2653 dihydrofissinolide 100 µM -0.185959857723664 0.435512983577943 no 1917 0.426238120538486 2786 6857746 SGTC_3304 9125678 46.087 µM -0.186021938710359 0.435488631911002 no 1918 0.426213778497695 2762 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1235 benzylparaben 21.5 µM -0.186249556995035 0.435399349265986 no 1919 0.426124531458814 2820 7180 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.186476571270698 0.435310306821732 no 1920 0.426035525014709 2813 279621 SGTC_3100 9120536 49.47 µM -0.186576796454175 0.435270996261146 no 1921 0.425996230503169 2681 16421196 SGTC_994 3910-0338 138 µM -0.186670803637434 0.435234125120835 no 1922 0.425959374502637 2902 3479481 SGTC_2261 9010538 184.68 µM -0.187264498688775 0.435001281323631 no 1923 0.425726628251946 2867 6457250 SGTC_1277 0873-0036 22 µM -0.188537100885124 0.434502250070743 no 1924 0.425227817333451 2806 5965735 SGTC_1431 4049-0260 9.09 µM -0.190683999772004 0.433660613792537 no 1925 0.424386587504709 2711 3854841 SGTC_37 0566-0070 1.56 µM -0.191964904777495 0.433158611036356 no 1926 0.423884848024861 2856 1626686 SGTC_1429 4049-0205 9.46 µM -0.19249620541106 0.432950419240432 no 1927 0.423676769987648 2740 22774478 SGTC_2742 clothiapine 36.27 µM -0.19266880803217 0.432882788371625 no 1928 0.423609176650234 2774 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2762 leflunomide 42.06 µM -0.193800030826556 0.432439590202907 no 1929 0.423166231436838 2756 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2312 7706453 155.7 µM -0.193822744390628 0.432430692196666 no 1930 0.423157338633624 2795 976098 SGTC_1959 st077091 55.8 µM -0.194279514622701 0.432251760391376 no 1931 0.422978512497365 2723 821356 YKL052C ASK1 SGTC_537 1334-0398 209 µM -0.194576582270864 0.432135396754212 no 1932 0.422862218643055 2872 5846986 SGTC_837 0091-0265 12.5 µM -0.19489982522615 0.432008786740157 no 1933 0.422735685509067 2751 759367 SGTC_3061 glucosamine 200 µM -0.195096433183542 0.431931781403632 no 1934 0.422658727417219 2752 91431 and experimental redox chemotherapeutic SGTC_580 1123-0028 41 µM -0.195829211509669 0.431644797302497 no 1935 0.422371922623253 2742 1677248 YPR107C YTH1 SGTC_2282 7944268 200 µM -0.19659559927396 0.431344689052208 no 1936 0.422072007338505 2927 2970414 SGTC_270 tamoxifen 5.46 µM -0.196883429513415 0.431231988412288 no 1937 0.421959380605272 2940 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1366 1683-0113 21.9 µM -0.199064689739984 0.430378093213251 no 1938 0.421106070962097 2753 708623 SGTC_603 3794-0023 45.9 µM -0.19948040356446 0.430215391047792 no 1939 0.420943485499441 2841 3802260 SGTC_1400 3771-8998 51.5 µM -0.200122305186554 0.429964186734559 no 1940 0.420692464596318 2769 670767 SGTC_2863 9028737 58.44 µM -0.200146130169899 0.429954863516572 no 1941 0.420683148260817 2866 6460917 SGTC_853 0419-0306 21 µM -0.200327698773134 0.429883813179776 no 1942 0.42061215055131 2762 762713 SGTC_1617 st002906 78 µM -0.200569436695277 0.429789221270385 no 1943 0.420517629192957 2745 5150859 SGTC_2377 9073351 62.6 µM -0.201375678933521 0.429473768313809 no 1944 0.420202415532081 2748 7337946 YHR072W ERG7 SGTC_2754 granisetron 64.02 µM -0.201539239310188 0.429409778637105 no 1945 0.420138475150576 2893 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_515 4092-1064 102 µM -0.20184462461875 0.429290307800917 no 1946 0.420019097030953 2983 717353 SGTC_164 4100-3994 89.624 µM -0.202566736942233 0.42900783353983 no 1947 0.41973684551421 2789 4615967 SGTC_887 0885-0007 9.62 µM -0.204372921778486 0.428301453747574 no 1948 0.419031044445687 2906 5719458 SGTC_2407 paclitaxel 400 µM -0.204666225617804 0.428186767333501 no 1949 0.418916454919988 3005 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_689 0833-0039 98 µM -0.204922861441093 0.428086423665502 no 1950 0.418816196694599 2819 5374726 SGTC_2808 7946468 45.46 µM -0.205042851114413 0.428039509737145 no 1951 0.418769322928348 2844 2970879 SGTC_2087 5276107 200 µM -0.205501044188737 0.427860373375382 no 1952 0.41859034118161 2757 144405 SGTC_1796 st049173 110.4 µM -0.205961232766519 0.427680471811668 no 1953 0.418410596903276 2752 94134 SGTC_404 fumagillin 50 µM -0.206590217506918 0.427434607073083 no 1954 0.418164950378875 2813 12015870 A methionine aminopeptidase binder. SGTC_1254 0550-0035 264 µM -0.206705862200349 0.427389405618668 no 1955 0.418119789452016 2911 15121435 SGTC_1836 st055642 81 µM -0.207273499867011 0.427167549797274 no 1956 0.417898134391004 2786 8571 SGTC_1031 k035-0009 16 µM -0.207619508027653 0.427032327070086 no 1957 0.417763035532391 2981 5180959 SGTC_136 0097-0015 404.482 µM -0.209395260935663 0.426338484029582 no 1958 0.417069845996799 2755 4861337 SGTC_1518 st038567 90.8 µM -0.209564207911869 0.426272482922783 no 1959 0.417003908616946 2735 77966 SGTC_1767 st044992 70.3 µM -0.211625448771623 0.425467401959818 no 1960 0.416199626864386 2837 9600693 SGTC_595 3909-8003 73.7 µM -0.212311289193141 0.425199594620128 no 1961 0.415932094343508 2884 699517 SGTC_2244 6635614 200 µM -0.212421246170725 0.425156661766834 no 1962 0.415889205963502 2738 836499 SGTC_2226 7298446 200 µM -0.21716883639509 0.423303811778096 no 1963 0.414038385037919 2888 3283010 SGTC_1336 1486-0901 104 µM -0.217573945728866 0.423145786985509 no 1964 0.413880543234057 2869 5006114 SGTC_935 2996-0153 430 µM -0.218309879371176 0.422858746103544 no 1965 0.413593838736115 2960 23738523 SGTC_865 0488-0499 301 µM -0.219292262504517 0.422475644799295 no 1966 0.413211194426328 2778 9634651 SGTC_1287 0971-0001 34.6 µM -0.220764146412429 0.421901789537701 no 1967 0.412638040905899 2805 4665869 SGTC_356 1634-0012 32.5 µM -0.221111524743033 0.4217663784794 no 1968 0.41250279844498 2863 735457 SGTC_412 gemfibrozil 100 µM -0.221247437319952 0.421713401105582 no 1969 0.41244988734497 2820 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2938 9059746 27.26 µM -0.222084030971404 0.421387336439062 no 1970 0.412124234454587 2923 6471769 SGTC_1957 st077035 62.4 µM -0.22262712801912 0.421175691716924 no 1971 0.411912860580141 2850 705593 SGTC_476 mead acid 10 µM -0.226525311315562 0.419657243100841 no 1972 0.410396437614285 2812 5312531 An omega 9 fatty acid. SGTC_17 0960-0276 49.807 µM -0.226570464162066 0.419639661797244 no 1973 0.410378880612765 2802 6821114 SGTC_2558 carylophyllene oxide 100 µM -0.228523284751801 0.418879439947081 no 1974 0.409619728181597 2797 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3334 9142812 21.919 µM -0.228724999846081 0.418800930625264 no 1975 0.409541331371152 2938 45283678 SGTC_3150 9097574 49.47 µM -0.228948080217729 0.418714109511901 no 1976 0.409454635132331 2941 17217476 SGTC_625 k213-0058 121 µM -0.229701538025474 0.418420898994834 no 1977 0.409161849845241 2864 3655420 SGTC_2387 9077560 195.08 µM -0.230300471191212 0.418187854562555 no 1978 0.408929147246721 2810 5303272 SGTC_2345 9052315 157.45 µM -0.231508702293103 0.41771782025827 no 1979 0.408459812802576 2904 6469265 SGTC_221 trifluoperazine 10.304 µM -0.231680040040261 0.417651174778675 no 1980 0.408393267681677 2823 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_654 1124-0271 80.9 µM -0.233028275495317 0.417126832456055 no 1981 0.407869724709117 2842 5403748 SGTC_2912 7964298 10.93 µM -0.233045459954022 0.417120150196449 no 1982 0.407863052748331 2891 2975850 SGTC_3284 9108171 64.8615 µM -0.233905498479789 0.416785750691235 no 1983 0.407529172221928 2935 8687505 SGTC_1583 clindamycin 39.6 µM -0.235546510817866 0.416147860779466 no 1984 0.40689229186078 2808 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2149 5554786 194.827 µM -0.235613673753273 0.416121758075838 no 1985 0.406866231015278 2839 745063 YPR165W RHO1 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.236537445435421 0.415762774154806 no 1986 0.40650782712265 3010 551469 SGTC_2549 cedrol 20.94 µM -0.237082383243174 0.4155510405784 no 1987 0.406296439470618 3006 6708665 A sedative which affects the nervous system. SGTC_1368 1852-0141 284 µM -0.237288637320998 0.415470907709344 no 1988 0.406216438259121 2933 2838987 SGTC_1863 st057641 20.1 µM -0.237744252362045 0.41529390675024 no 1989 0.406039729548787 2808 3921635 SGTC_2605 digitonin 300 nM -0.238434324681582 0.415025854704658 no 1990 0.405772123857358 2895 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_467 ro 31-8220 72.8 µM -0.239355170494121 0.41466822251027 no 1991 0.405415094257036 2891 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1262 0737-0114 49.6 µM -0.241233744950035 0.413938853399407 no 1992 0.404686979175235 2962 765919 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.241321949567334 0.41390461464074 no 1993 0.404652800111721 2863 689007 SGTC_948 3448-0295 75.3 µM -0.241808933027667 0.413715592003005 no 1994 0.404464108370175 2820 678569 SGTC_1096 rimcazole 32.2 µM -0.242407180246702 0.413483409704453 no 1995 0.404232335617918 2812 18528119 A dopamine reuptake inhibitor. SGTC_2523 spermine 47.74 µM -0.242838669599901 0.413315965616965 no 1996 0.404065189004165 2965 1103 A DNA binding polyamine. SGTC_3020 9089140 49.47 µM -0.24286545827265 0.413305570503647 no 1997 0.404054812416899 2918 17217859 SGTC_3004 9076122 71.4286 µM -0.243602563182882 0.413019567169422 no 1998 0.403769321480198 2992 44782551 SGTC_424 splitomicin 100 mM -0.244145597348747 0.412808894549784 no 1999 0.403559029612861 2917 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_549 1661-1316 519 µM -0.24530769846335 0.412358136483252 no 2000 0.403109095660638 2966 2857282 SGTC_2430 5571206 200 µM -0.246651797499395 0.411836928883319 no 2001 0.402588857044366 3003 1731771 SGTC_762 1165-0429 115 µM -0.246751907512735 0.411798114964104 no 2002 0.402550115974311 2986 5967793 SGTC_2961 9083290 32.55 µM -0.24722579869157 0.411614393073766 no 2003 0.402366740206043 2907 17741490 SGTC_1565 sinapyl alcohol 95.1 µM -0.247512823746979 0.411503126343602 no 2004 0.402255684138306 2928 5280507 A phenol propionate derived from cinnamic acid. SGTC_3049 9092223 49.47 µM -0.24777094906779 0.411403068821075 no 2005 0.402155816727048 2945 8623917 SGTC_1631 benzylvanillin 81.9 µM -0.249154683772867 0.410866787962741 no 2006 0.401620565651398 2983 75506 SGTC_1153 4055-0057 267 µM -0.250462915862698 0.410359922086679 no 2007 0.401114689875643 2853 882706 SGTC_50 0929-0078 56.389 µM -0.250747293853577 0.410249761491855 no 2008 0.401004746626985 2866 1377751 SGTC_2964 9083345 53.42 µM -0.251658904832687 0.409896675022561 no 2009 0.400652361997347 2902 17741579 SGTC_1381 2324-0066 62.1 µM -0.252357946175335 0.409625970798224 no 2010 0.400382201231634 2971 10885928 SGTC_2021 4019055 173 µM -0.253209279604186 0.40929634955135 no 2011 0.400053248021841 2983 44827708 YER133W GLC7 SGTC_2915 7971052 15.16 µM -0.254798031877649 0.408681384417819 no 2012 0.399439547724855 2866 5741558 SGTC_2424 5537928 59.2 µM -0.256273266834501 0.408110560126447 no 2013 0.398869919052313 2883 5382802 SGTC_1229 0139-0193 12.2 µM -0.256533081021082 0.408010048332485 no 2014 0.398769619936562 2992 3090752 SGTC_1534 6-azauridine 81.6 µM -0.257091628948842 0.407793988816805 no 2015 0.398554019774267 2842 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2404 5161160 200 µM -0.257317396671689 0.407706664489043 no 2016 0.398466881947586 2809 2831543 SGTC_2849 9019321 12.99 µM -0.260658223926791 0.406415009571201 no 2017 0.397178042516652 2990 16489627 SGTC_2879 9041815 71.43 µM -0.261516571397875 0.406083312794767 no 2018 0.396847085959648 2983 4942971 SGTC_2896 9052656 71.43 µM -0.261847094982348 0.405955604384767 no 2019 0.396719664421465 2976 6469436 SGTC_2798 7813637 45.45 µM -0.261880269109577 0.405942787046857 no 2020 0.396706875932784 3011 956368 SGTC_2077 5212015 200 µM -0.262429013419896 0.40573078581951 no 2021 0.396495353401641 2805 780900 SGTC_2420 aureobasidin a 50 nM -0.263708631314021 0.405236527259223 no 2022 0.396002222039709 3143 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2699 st077704 54.6 µM -0.264584038114704 0.40489848416705 no 2023 0.395664958889293 2925 645852 SGTC_859 0439-0102 54.6 µM -0.266354416073702 0.404215060195917 no 2024 0.39498313409221 3000 610143 SGTC_1699 st031318 29.054 µM -0.268639428875822 0.403333402529237 no 2025 0.394103583691146 2981 5340658 SGTC_3037 9091026 49.47 µM -0.268643397204784 0.403331871800636 no 2026 0.394102056664536 2974 25236398 YIL048W NEO1 SGTC_407 eburnamonine 100 µM -0.268921521548547 0.403224592831204 no 2027 0.393995037518649 2856 3195 SGTC_3163 9099914 49.47 µM -0.269358177930477 0.403056179096927 no 2028 0.393827033163178 2970 16268368 SGTC_2273 7815444 169.05 µM -0.269557868319089 0.402979166622672 no 2029 0.393750208497039 3067 2824616 SGTC_3218 9131285 49.47 µM -0.269708458052554 0.402921092766401 no 2030 0.393692276515705 3050 17156417 SGTC_2393 9031399 185.94 µM -0.270227711766165 0.402720862707395 no 2031 0.39349253728136 3045 1526623 YDL150W RPC53 SGTC_644 1498-1197 63.3 µM -0.270270539808111 0.402704348872028 no 2032 0.393476064041372 2993 6741615 SGTC_539 4859-0462 2.54 µM -0.270575678545442 0.40258669708607 no 2033 0.39335870198168 3047 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3215 9129942 49.47 µM -0.271027642447473 0.402412450402774 no 2034 0.393184886027794 3010 17682944 SGTC_1750 st081859 2.357 µM -0.273123853090031 0.401604547494831 no 2035 0.392379005720959 2915 5291695 SGTC_2656 pseudo-anisatin 100 µM -0.274294969991907 0.401153368818427 no 2036 0.391928974850077 2910 6708809 A neurotoxin. SGTC_2382 9035899 200 µM -0.274640397183041 0.401020316396408 no 2037 0.391796263417159 2905 6462679 SGTC_2152 5568786 200 µM -0.274954030444394 0.400899520374345 no 2038 0.391675777960444 2895 5399883 SGTC_2693 st077581 40.7 µM -0.276806739366874 0.400186142179496 no 2039 0.390964253019642 3014 25238761 SGTC_165 k038-0023 64.381 µM -0.277065349216232 0.400086591910842 no 2040 0.390864963975829 2907 46368543 SGTC_441 propafenone 146 µM -0.277375395639351 0.399967250007983 no 2041 0.390745936074103 2869 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2111 5486399 200 µM -0.277400319428045 0.399957656842538 no 2042 0.390736368189163 2902 689674 SGTC_1581 himbacine 57.9 µM -0.279620931212425 0.399103186417551 no 2043 0.389884173330089 2892 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1456 k015-0012 13 µM -0.279623787810713 0.399102087535876 no 2044 0.389883077405214 3074 2989616 SGTC_1737 st035557 69.7 µM -0.280474801941298 0.398774753436079 no 2045 0.389556627545361 2834 5716916 SGTC_523 1934-0222 13.7 µM -0.280548957387192 0.398746233651755 no 2046 0.38952818513029 2906 1361595 SGTC_1000 4048-0884 8.67 µM -0.28133111070272 0.39844545466035 no 2047 0.389228225299314 3033 13040088 SGTC_637 1181-0519 7.26 µM -0.281495003456435 0.398382436934669 no 2048 0.389165379940645 2914 6252091 YGR060W ERG25 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.282836147812595 0.397866858765676 no 2049 0.388651221628964 2894 6708784 An antioxidant flavonoid SGTC_507 nimesulide 162 µM -0.283599683396987 0.397573411214914 no 2050 0.388358589882334 3108 4495 A COX2 inhibitor. SGTC_1499 4480-0877 67.3 µM -0.284009893075218 0.397415780367512 no 2051 0.388201399559153 2908 2861909 SGTC_868 0527-0199 213 µM -0.284586989736573 0.397194048398278 no 2052 0.3879802899763 2932 2849450 SGTC_1392 3455-1037 33.9 µM -0.285281219093444 0.396927355754781 no 2053 0.387714350136316 3063 981132 SGTC_427 1354-0053 47.3 µM -0.287975992941895 0.395892598881142 no 2054 0.386682557724182 3135 6813657 SGTC_2201 6605497 169.863 µM -0.288869479225421 0.395549673676329 no 2055 0.386340630273504 2945 670741 SGTC_1949 st076024 69.1 µM -0.288915878724759 0.395531867486168 no 2056 0.386322876099458 2852 2921930 SGTC_211 3455-0679 143.504 µM -0.289177072079479 0.395431636454242 no 2057 0.386222938249991 3000 748649 SGTC_2793 7325131 81.82 µM -0.289201882352668 0.39542211605369 no 2058 0.386213445731142 2982 4176441 SGTC_1175 0741-0056 27.6 µM -0.290082447619266 0.395084258819024 no 2059 0.385876581762497 3111 765927 SGTC_2946 9065502 71.43 µM -0.290754487707616 0.394826462034142 no 2060 0.385619547857973 2946 16489101 SGTC_612 0302-0167 22.4 µM -0.2913526417971 0.394597046884027 no 2061 0.385390815229572 2992 235821 SGTC_362 0310-0100 9.03 µM -0.292757910873174 0.394058215957444 no 2062 0.384853600799479 3048 790235 SGTC_1727 st034309 9.9045 µM -0.295395517187362 0.393047410493737 no 2063 0.383845878684751 3179 870305 SGTC_872 0588-0139 234 µM -0.29619898886109 0.392739640277155 no 2064 0.383539060492119 2919 2047100 SGTC_2708 st078559 56 µM -0.296377403028253 0.392671307734425 no 2065 0.383470940158902 3014 17250902 SGTC_593 1203-0218 61.7 µM -0.297464348783433 0.392255079559388 no 2066 0.383056011167195 3066 3666956 SGTC_2124 5246320 200 µM -0.297766188205019 0.392139516911767 no 2067 0.382940811230507 3026 579342 SGTC_2602 kawain 100 µM -0.297924500311058 0.392078909128096 no 2068 0.382880394021569 2936 5369129 SGTC_2584 androsterone 48.74 µM -0.298670489614893 0.391793351837094 no 2069 0.38259573785752 3063 2754130 A steroid. SGTC_1165 k072-0275 30.3 µM -0.300272998420457 0.391180124661133 no 2070 0.38198446380464 3040 6153523 YGL055W OLE1 SGTC_2285 7945142 200 µM -0.301023664555557 0.390892962442387 no 2071 0.381698224632294 3050 2970608 SGTC_3133 9127736 49.47 µM -0.302171904602706 0.39045382616015 no 2072 0.381260510312199 3106 27243420 SGTC_1440 4100-1550 40 µM -0.302999852886384 0.390137269851001 no 2073 0.38094498685549 2968 742806 SGTC_1920 st075728 45.7 µM -0.303921354787471 0.38978503006674 no 2074 0.380593904051034 3132 3400306 SGTC_387 norethindrone acetate 66.7 µM -0.304476977821482 0.389572689480851 no 2075 0.380382264847091 2981 541197 SGTC_3116 9124943 49.47 µM -0.305471218770824 0.389192806061172 no 2076 0.380003643580004 2959 41905195 YPL160W CDC60 SGTC_2258 7960471 200 µM -0.306629400511889 0.388750417046291 no 2077 0.379562736297377 3017 2974708 SGTC_787 4152-0075 138 µM -0.307407421544106 0.388453318420366 no 2078 0.379266639964849 2966 9566539 SGTC_581 0958-0271 211 µM -0.308450270658012 0.388055193716001 no 2079 0.378869867445355 2955 4591145 SGTC_355 1311-2252 105 µM -0.310742436994973 0.387180535664533 no 2080 0.377998216574954 2964 5338538 SGTC_147 4466-0538 29.23 µM -0.311099163528534 0.387044465265359 no 2081 0.377862618515337 3168 6742687 YHR072W ERG7 SGTC_452 diindolylmethane 8 µM -0.311251541193634 0.386986346289426 no 2082 0.377804701657647 3066 3071 Inhibits expression of several cancer promoting factors. SGTC_2177 5811945 192 µM -0.311579735184415 0.386861177111467 no 2083 0.377679968529303 3112 5343475 SGTC_1927 st060202 13.8 µM -0.312653561966369 0.386451714995032 no 2084 0.377271940038961 2936 688887 SGTC_2772 vinpocetine 57.06 µM -0.313095648660961 0.386283179117746 no 2085 0.37710399744732 3160 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_272 doxorubicin 8.13 µM -0.314567774933705 0.38572211802059 no 2086 0.376544924873624 2951 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_741 4582-0002 126 µM -0.315102383728621 0.385518425438896 no 2087 0.376341959346511 2948 2912688 SGTC_684 1140-0066 328 µM -0.315178516484957 0.385489420481316 no 2088 0.376313058140485 3023 6813534 SGTC_3144 9087057 49.47 µM -0.316426550335391 0.385014037591527 no 2089 0.375839383600849 3099 17249618 SGTC_3258 9138477 49.47 µM -0.317539366675047 0.384590305471532 no 2090 0.375417186762756 3002 4970355 SGTC_151 3013-0144 2.285 µM -0.317673431733118 0.384539266205493 no 2091 0.375366333222388 3159 906558 YHR107C CDC12 SGTC_1607 st000305 50.6 µM -0.317683451626049 0.384535451660423 no 2092 0.375362532564878 3110 5457690 SGTC_2413 inermin 26.06 µM -0.318052087806767 0.384395120677426 no 2093 0.375222713149512 3246 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_951 1171-0579 82.7 µM -0.318164515017696 0.384352325339339 no 2094 0.37518007407739 2905 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1042 0350-0096 82 µM -0.319133693005737 0.383983466928968 no 2095 0.374812567548898 2958 3122515 SGTC_2902 5787006 60.46 µM -0.319137537110351 0.383982004114301 no 2096 0.374811110113372 2964 591003 SGTC_1915 st067105 30.6 µM -0.319714855568816 0.383762333263221 no 2097 0.374592248650021 2953 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1419 3993-2473 62.6 µM -0.320447516388292 0.383483608109041 no 2098 0.374314555055052 3007 704026 SGTC_2639 lactacystin 53 µM -0.320895445945644 0.383313232566407 no 2099 0.374144812595954 3115 3870 A proteasome inhibitor. SGTC_1056 3448-1962 115 µM -0.322018800165279 0.382886050228561 no 2100 0.373719226015637 3047 715507 SGTC_197 4544-0043 41.561 µM -0.322136148436039 0.382841433945637 no 2101 0.373674777093935 2961 896523 SGTC_1147 3809-1045 12.3 µM -0.324538639166628 0.381928339839702 no 2102 0.372765137019269 2995 325925 SGTC_226 1,3-diallylurea 8.28947 mM -0.325005019288457 0.381751162660706 no 2103 0.372588636449971 3067 74537 YKL182W FAS1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.325179215516285 0.381684992100292 no 2104 0.37252271911654 3219 6728940 SGTC_505 gw-5074 63.9 µM -0.325697555690954 0.381488114723293 no 2105 0.372326596880138 3076 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_359 0081-0058 15.9 µM -0.326473335027377 0.381193513398447 no 2106 0.372033130317937 3348 3494159 SGTC_975 1335-0046 28.5 µM -0.327109352282433 0.380952037909698 no 2107 0.371792589245541 3002 16486740 SGTC_2125 5246583 200 µM -0.327724783405361 0.38071842244783 no 2108 0.371559881461748 3142 835267 SGTC_135 0933-0004 26.348 µM -0.327954468796462 0.380631245829799 no 2109 0.37147304448222 3094 21230617 YGL099W LSG1 SGTC_1363 1636-0063 10.4 µM -0.32852821079462 0.380413509721284 no 2110 0.371256158870268 2993 6072185 SGTC_216 k038-0035 28.382 µM -0.331799315125397 0.379172845415812 no 2111 0.370020400732956 3078 4444231 YPR107C YTH1 SGTC_22 0964-0034 14.468 µM -0.333506527874637 0.378525826862255 no 2112 0.369375981353725 3041 138402 SGTC_3220 9131269 49.47 µM -0.33597899905002 0.377589385967914 no 2113 0.368443351600748 3018 17722206 SGTC_2567 aureobasidin a 60 nM -0.336969652990333 0.377214380288551 no 2114 0.368069888496706 3222 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1451 4152-0210 104 µM -0.338795364811729 0.376523572309401 no 2115 0.367381946671517 3161 659563 SGTC_3026 9090633 49.47 µM -0.338873536050718 0.376494002892809 no 2116 0.367352500648291 2986 25236842 SGTC_1151 3909-8316 15.3 µM -0.341029616087642 0.375678720245418 no 2117 0.366540643164109 3118 800431 SGTC_1284 0929-0043 16 µM -0.34226851986139 0.375210501932921 no 2118 0.366074411995245 3052 1239883 SGTC_2740 felodipine 17.08 µM -0.343280857657451 0.374828046012644 no 2119 0.36569359011107 3090 3333 L-type calcium channel blocker SGTC_1578 josamycin 24.2 µM -0.344071510399421 0.374529427120689 no 2120 0.365396253863816 3016 5282165 A P450 substrate. SGTC_756 0508-1999 28.3 µM -0.34540384512433 0.374026392533757 no 2121 0.364895393432084 3011 6753853 SGTC_677 0929-0063 136 µM -0.346397275006161 0.373651453932472 no 2122 0.364522086365998 3058 1539583 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.346495068800957 0.37361455122425 no 2123 0.364485344747977 2985 3256 An antibiotic and ribosome inhibitor. SGTC_1230 0170-0365 3.77 µM -0.348921551738553 0.372699284309626 no 2124 0.363574102429401 3145 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3280 9140961 49.47 µM -0.348928374161228 0.372696711908927 no 2125 0.363571541419197 2993 4901226 SGTC_3308 9128332 17.569 µM -0.349016941318093 0.372663318096882 no 2126 0.363538295514003 3176 17332805 YDL196W YDL196W SGTC_54 0159-0055 9 µM -0.351165042034895 0.371853680917098 no 2127 0.362732267265195 3258 3319099 SGTC_2448 5185112 27.17 µM -0.35140014459493 0.371765103112804 no 2128 0.362644086965446 3144 5718189 SGTC_632 0781-2353 4.65 µM -0.352513688578941 0.371345653899585 no 2129 0.362226527246872 3116 6811515 YHR007C ERG11 SGTC_3034 9090421 49.47 µM -0.353383257692916 0.371018211208582 no 2130 0.361900567810754 3067 17173761 SGTC_1991 st073000 8.92 µM -0.353660853228121 0.370913700202389 no 2131 0.361796531738553 3220 4301969 YIL048W NEO1 SGTC_2745 rifampicin 24.3 µM -0.354845956565751 0.370467631827895 no 2132 0.361352498716928 3068 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2354 9060492 162 µM -0.358543856969816 0.369076877870851 no 2133 0.359968176644402 3187 6471895 SGTC_2214 7179297 48.276 µM -0.35914008389965 0.368852800990784 no 2134 0.35974514826542 3058 769744 SGTC_1686 st019653 115.5 µM -0.359415026196758 0.368749485862343 no 2135 0.359642317711064 3167 97252 SGTC_199 4063-0024 41.6 µM -0.360369619941382 0.368390851635796 no 2136 0.359285371163693 3151 306215 SGTC_1850 st056238 17 µM -0.360761836204349 0.368243531922356 no 2137 0.359138747232436 3037 5393177 SGTC_3073 9114972 49.47 µM -0.36077131437536 0.368239972081564 no 2138 0.359135204222706 3144 41905075 SGTC_1086 cerivastatin 2.18 µM -0.362079993108662 0.367748563207768 no 2139 0.358646126969091 3113 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1646 st011709 75.6 µM -0.362128372555865 0.367730400868243 no 2140 0.358628051118498 3153 5757843 SGTC_2861 9024595 19.48 µM -0.362783182934008 0.367484604754182 no 2141 0.358383427678013 3073 16482810 SGTC_2126 5251174 33.877 µM -0.363459401395471 0.367230829658703 no 2142 0.358130867612026 3225 790722 SGTC_2385 9074692 200 µM -0.364299254960372 0.366915725397477 no 2143 0.357817278080062 3072 17046906 SGTC_3029 9088683 49.47 µM -0.366057770984485 0.366256239178102 no 2144 0.357160983826121 3184 25236615 SGTC_1243 0416-0003 5.65 µM -0.367188400400879 0.365832434084947 no 2145 0.356739245542984 3059 2141977 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.369407797917645 0.365000991610121 no 2146 0.355911893249793 3082 6708630 An antioxidant. SGTC_2486 5283202 22.39 µM -0.37088761433837 0.364446967143628 no 2147 0.355360620307322 3085 1377751 SGTC_2712 st079126 47.7 µM -0.371134344573333 0.364354621978901 no 2148 0.355268735797099 3034 3152970 SGTC_3138 9097216 49.47 µM -0.371584155029702 0.364186289058135 no 2149 0.355101244080101 3090 25237486 SGTC_561 1550-0330 72.9 µM -0.372013263478994 0.364025727881154 no 2150 0.354941487065427 3073 6812934 SGTC_678 1218-2179 85.9 µM -0.372201933167967 0.363955140162202 no 2151 0.354871253436432 3127 6820081 YOR116C RPO31 SGTC_2825 7998094 58.44 µM -0.372288513320361 0.363922749140651 no 2152 0.354839025011804 3102 2987815 SGTC_117 lucigenin 22.078 µM -0.372552456145376 0.363824009903801 no 2153 0.354740781868176 3144 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1405 3909-7894 12 µM -0.37352509371264 0.36346023082613 no 2154 0.354378836243708 3147 7104060 SGTC_2367 9070478 135.38 µM -0.373835822995805 0.363344039968005 no 2155 0.354263232888302 3033 572802 SGTC_440 fluspirilene 35.1 µM -0.374167034436136 0.363220204068936 no 2156 0.354140024160333 3267 3396 An atypical antipsychotic. SGTC_3340 9146634 11.102 µM -0.376303488209446 0.362421754218035 no 2157 0.353345643179476 3156 4907387 SGTC_2326 6164455 177.58 µM -0.37930564728557 0.361300778447859 no 2158 0.352230453260856 3130 2888790 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.379613271135339 0.361185981864067 no 2159 0.352116254037957 3186 61125 An anti-inflammatory. SGTC_2460 5552655 174.22 µM -0.381201885924732 0.36059335458177 no 2160 0.351526724911317 3191 5401989 SGTC_3012 9080433 71.4286 µM -0.382485937917977 0.360114587898334 no 2161 0.351050478687132 3192 17688859 SGTC_1068 loratadine 26.9 µM -0.382950995054406 0.35994124254778 no 2162 0.350878049780011 3116 3957 A H1 histamine antagonist. SGTC_1052 3253-3998 198 µM -0.383344387970431 0.359794631795485 no 2163 0.35073221573703 3027 5450317 SGTC_1477 0139-0234 16 µM -0.385821696024736 0.358871856576295 no 2164 0.349814362983588 3135 620880 SGTC_1080 nisoldipine 24.4 µM -0.385974357221868 0.358815018505649 no 2165 0.34975783002021 3006 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_95 0471-0001 561.058 µM -0.386617350147675 0.358575656848255 no 2166 0.34951975569132 3096 4015405 SGTC_666 0272-0154 136 µM -0.386918893636696 0.358463422874577 no 2167 0.349408126685889 3106 6870312 SGTC_1864 st057645 30.4 µM -0.387881665343098 0.358105162749334 no 2168 0.349051803457303 3186 688666 SGTC_2617 dihydrotanshinone i 20.83 µM -0.387902329884964 0.358097474567319 no 2169 0.34904415693729 3072 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_903 1134-0042 114 µM -0.388145355566398 0.358007061895957 no 2170 0.348954234513916 3099 701009 SGTC_2532 xanthone 78.9 µM -0.38900116804215 0.35768873801864 no 2171 0.348637641167099 3190 7020 An insecticide. SGTC_1468 k284-1086 134 µM -0.390125367213653 0.357270736722514 no 2172 0.348221922867696 3116 15996457 SGTC_3354 9151612 71.43 µM -0.390305242778426 0.357203871016855 no 2173 0.34815542347744 3200 27261949 SGTC_1851 st056236 18.9 µM -0.392759097771469 0.356292130547978 no 2174 0.3472487085775 3265 5393171 SGTC_519 k048-0011 62.8 µM -0.393103632116378 0.356164182918875 no 2175 0.347121470785428 3184 6836379 SGTC_3265 9137266 49.47 µM -0.39453276470471 0.35563362766206 no 2176 0.3465938710255 3165 17224265 SGTC_2062 5245942 200 µM -0.394694315202484 0.355573670763711 no 2177 0.346534249342512 3137 1376160 SGTC_3291 9121177 71.43 µM -0.394767231026552 0.355546610385439 no 2178 0.346507340338403 3112 17015612 SGTC_661 1304-0007 33.6 µM -0.395354427284391 0.35532871780838 no 2179 0.346290668481322 3132 3117130 SGTC_2011 4012611 177 µM -0.397069130100402 0.354692709053752 no 2180 0.345658241647479 3066 2049887 SGTC_3285 9112818 20.8695 µM -0.397154345738826 0.354661111852466 no 2181 0.345626823126256 3100 17017947 YPR165W RHO1 SGTC_314 1671-0008 2.74 µM -0.397755328686965 0.354438301122431 no 2182 0.345405274334959 3129 3913060 SGTC_503 tyrphostin 8 294 µM -0.398155576525903 0.354289939324569 no 2183 0.345257754721044 3189 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2951 9072950 58.06 µM -0.398494130680845 0.354164463082624 no 2184 0.345132991939969 3166 16488155 SGTC_1018 4259-0013 28.1 µM -0.398689249721928 0.354092154504615 no 2185 0.34506109500483 3220 6801262 SGTC_3115 9123671 49.47 µM -0.399277779026489 0.353874085077544 no 2186 0.344844269207665 3235 3286988 SGTC_395 anisomycin 6.25 µM -0.399830876416581 0.353669188024053 no 2187 0.344640543661931 3157 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2199 6590217 200 µM -0.400092984394203 0.353572103915454 no 2188 0.344544015650638 3136 703109 SGTC_1660 st012960 28.1 µM -0.400389742207003 0.353462197094939 no 2189 0.344434739163445 3188 24207266 SGTC_1268 0828-0275 2.46 µM -0.402086747969785 0.352833931280674 no 2190 0.343810092617953 3208 745337 SGTC_3038 9091290 49.47 µM -0.404059056573807 0.352104246818121 no 2191 0.34308464601839 3275 25236843 SGTC_664 1222-0054 14.9 µM -0.404461548357503 0.351955405859992 no 2192 0.342936674035869 3131 6813991 SGTC_62 0180-0423 3.232 µM -0.405894110627931 0.351425830295634 no 2193 0.342410202758612 3153 30102 YGL099W LSG1 SGTC_1651 st011928 86.1 µM -0.406095821612432 0.351351286887878 no 2194 0.342336097876751 3212 720198 SGTC_1707 st032323 6.317 µM -0.409738034136387 0.350006273334929 no 2195 0.34099906320638 3154 3132057 YMR211W DML1 SGTC_1288 0973-0013 65.5 µM -0.411669100428311 0.349293921336356 no 2196 0.340290988050993 3246 4315430 SGTC_2968 9090663 33.37 µM -0.412356842625388 0.349040347772578 no 2197 0.340038945441063 3146 25236811 SGTC_2339 9000433 200 µM -0.412425719659032 0.349014956219045 no 2198 0.340013707436504 3161 2988954 SGTC_2179 6298986 200 µM -0.412570164989793 0.348961708569823 no 2199 0.339960781935038 3237 738374 SGTC_3125 9127534 49.47 µM -0.414141191032119 0.348382765176224 no 2200 0.339385353919761 3196 1639235 SGTC_104 0074-0074 590.992 µM -0.414891365695347 0.348106440576151 no 2201 0.339110715433178 3143 3943124 SGTC_1661 st013063 9.66 µM -0.415411762325202 0.347914801384153 no 2202 0.338920248744355 3147 721395 SGTC_469 w7 172 µM -0.415676911813209 0.347817173422741 no 2203 0.338823219085907 3205 45115570 A P450 inhibitor. SGTC_3335 9143315 29.6265 µM -0.41589307345056 0.347737590238111 no 2204 0.33874412411182 3147 4899691 SGTC_149 3970-0822 46.1 µM -0.416245950439714 0.347607687639714 no 2205 0.338615019364878 3269 3114250 YBL034C STU1 SGTC_3153 9100258 49.47 µM -0.417257356263328 0.347235463743903 no 2206 0.338245088177644 3126 25236848 SGTC_2721 ifenprodil 61.44 µM -0.417480086474447 0.347153512958161 no 2207 0.338163643469386 3267 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_955 1216-0110 33 µM -0.422171027689545 0.345429205612231 no 2208 0.336450093523819 3152 3619719 SGTC_2206 7254556 146.969 µM -0.424893462008621 0.34442995302442 no 2209 0.335457170480914 3193 4398905 SGTC_3205 9113483 49.47 µM -0.426058037908212 0.344002833544366 no 2210 0.335032777919769 3296 17018033 SGTC_541 4513-1321 94 µM -0.426786228240687 0.343735863758629 no 2211 0.33476751910983 3171 747515 SGTC_2249 haloperidol 116.36 µM -0.427686503192558 0.343405911866263 no 2212 0.334439688775279 3177 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1064 honokiol 6.76 µM -0.427716083644169 0.343395072616964 no 2213 0.334428919351437 3229 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_268 camptothecin 39.6153 µM -0.428298342249482 0.343181740164886 no 2214 0.334216962853299 3254 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_662 k832-1615 104 µM -0.430754468065981 0.342282396249193 no 2215 0.333323454832295 3235 5878478 SGTC_509 pifithrin 175 µM -0.431205495287634 0.342117343468421 no 2216 0.333159479290107 3272 4817 A p53 inhibitor. SGTC_94 0334-0113 514.748 µM -0.433029146749026 0.341450288567791 no 2217 0.332496797624737 3195 6795178 SGTC_483 fpl-64176 144 µM -0.433533434305745 0.34126591762922 no 2218 0.332313640979016 3251 3423 SGTC_93 0109-0045 59.227 µM -0.434163358630372 0.341035666259876 no 2219 0.332084909455278 3255 88733 SGTC_3089 9117425 49.47 µM -0.434603592439886 0.340874786129284 no 2220 0.331925093491094 3232 9401657 SGTC_2985 9022375 71.43 µM -0.434607313125076 0.340873426556163 no 2221 0.331923742918888 3331 4939335 SGTC_1770 st043884 66.3 µM -0.438846292868069 0.339325810070102 no 2222 0.330386457225916 3186 670149 SGTC_1301 naphtanilide LB 4.81 µM -0.438861740805703 0.339320175089566 no 2223 0.330380860171004 3294 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_409 arachidonic acid 100 µM -0.439475729728069 0.339096238013529 no 2224 0.33015843210481 3192 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.439749191095634 0.338996518119999 no 2225 0.330059385324546 3253 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_48 0382-0018 55 µM -0.439942335528023 0.338926093241282 no 2226 0.32998943624228 3420 762596 SGTC_1939 st074455 53.6 µM -0.440101302950507 0.338868134305287 no 2227 0.329931869146168 3357 1644229 SGTC_946 3434-1334 87.4 µM -0.440941779349278 0.338561763134919 no 2228 0.32962757321021 3270 4047976 SGTC_1640 st009078 66.4 µM -0.442467772950466 0.338005779772559 no 2229 0.329075372904728 3268 690618 SGTC_2331 7980721 200 µM -0.442752575700308 0.337902053278647 no 2230 0.328972354628077 3203 2981221 SGTC_2898 9056270 58.44 µM -0.445891389541552 0.336759699394397 no 2231 0.327837851144067 3248 19154699 SGTC_1176 0848-0131 83.3 µM -0.446075866507073 0.336692606734905 no 2232 0.327771222446777 3247 6769040 SGTC_2417 cerulenin 830 nM -0.446607893992407 0.336499142105658 no 2233 0.327579097471632 3329 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3136 9095672 49.47 µM -0.447308147705815 0.336244570243034 no 2234 0.327326292473961 3205 17217380 SGTC_2099 5377090 177.372 µM -0.447608484167515 0.336135408224415 no 2235 0.32721788951593 3271 2243829 SGTC_2853 9015042 58.44 µM -0.447914111686876 0.33602433727182 no 2236 0.327107591771435 3082 6457456 SGTC_2764 methyldopa 94.69 µM -0.44797313044343 0.336002890363012 no 2237 0.327086294264429 3352 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2521 angolensin 13.4 µM -0.452088024654334 0.334508892970958 no 2238 0.325602785202162 3320 821428 A flavenoid. SGTC_264 promethazine 12.5 mM -0.45792109326134 0.332395564329816 no 2239 0.323504566017123 3356 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1136 pergolide 1.05886 µM -0.45805689024676 0.332346427981621 no 2240 0.323455784791202 3160 47811 A dopamine receptor agonist. SGTC_1794 st048918 76.9 µM -0.462284814837754 0.330818054253336 no 2241 0.321938543865184 3271 672303 SGTC_2034 5197015 53.07 µM -0.463897686431371 0.330235749755378 no 2242 0.321360525237363 3342 780676 SGTC_1758 st042942 75.2445 µM -0.464956815977371 0.329853589415859 no 2243 0.320981190980344 3304 669317 SGTC_2080 5212524 12.4 µM -0.467790881762609 0.328831861820309 no 2244 0.319967070945902 3320 260183 SGTC_641 4092-0595 30 µM -0.468549000358377 0.328558763849628 no 2245 0.319696019203659 3310 786260 SGTC_2016 5121758 140 µM -0.469765921212277 0.328120582462803 no 2246 0.319261132252784 3276 2795203 SGTC_2048 5246248 200 µM -0.469894422594463 0.328074326264853 no 2247 0.319215224641264 3332 677046 SGTC_1196 1588-0294 184 µM -0.470057863200649 0.328015496924777 no 2248 0.319156838862965 3256 6144269 SGTC_2515 chrysin 20.77 µM -0.471176085819467 0.327613114779018 no 2249 0.318757497333571 3284 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2807 7945238 51.95 µM -0.471377094055936 0.327540805017637 no 2250 0.318685735229515 3285 17148797 SGTC_1997 st073024 93.8 µM -0.471711526234515 0.327420512287505 no 2251 0.318566354409777 3329 686268 SGTC_2845 9003024 42.97 µM -0.473175287062792 0.326894219529833 no 2252 0.318044063712759 3421 2990173 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.474066542163203 0.326573938744406 no 2253 0.317726228277318 3323 66535 A nucleotide analog. SGTC_3130 9127414 49.47 µM -0.474743358448108 0.326330803886554 no 2254 0.317484954741516 3313 1494646 SGTC_2290 7904846 200 µM -0.474771986753814 0.326320521275303 no 2255 0.317474750943747 3282 2962154 SGTC_3062 9077494 49.47 µM -0.475541393941791 0.32604421785476 no 2256 0.317200568197796 3326 16459633 SGTC_635 k038-0028 24.7 µM -0.476318786183552 0.325765143873608 no 2257 0.316923641799531 3254 4035102 SGTC_3217 9129673 49.47 µM -0.478187469272443 0.32509470982609 no 2258 0.316258390201706 3383 17248312 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.478205921655588 0.325088092417367 no 2259 0.316251824108876 3145 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3287 9117173 37.0625 µM -0.478252601953292 0.325071352137192 no 2260 0.316235213658496 3262 2789709 SGTC_2155 5570423 76 µM -0.479756683300007 0.324532154341243 no 2261 0.315700208568806 3232 797402 SGTC_1752 st044819 83.042 µM -0.480183153722356 0.324379335894868 no 2262 0.315548582272834 3226 441209 YML126C ERG13 SGTC_275 trichlorophene 5.69 µM -0.48020535650459 0.324371380713913 no 2263 0.31554068919768 3340 62616 SGTC_482 fipronil 114 µM -0.480454176238855 0.324282234937219 no 2264 0.31545223969499 3318 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1396 3511-0007 98.6 µM -0.48048451689935 0.324271365339751 no 2265 0.315441455034347 3320 X1396 SGTC_459 nigericin 15.3 µM -0.480532313976252 0.324254242252763 no 2266 0.315424465767495 3370 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_484 loperamide 105 µM -0.481075046303667 0.324059836926013 no 2267 0.315231581257694 3263 3955 An opioid-receptor agonist. SGTC_1389 3405-0187 19 µM -0.481575075607651 0.323880770166546 no 2268 0.315053917767534 3270 799890 SGTC_1613 st002381 52.1 µM -0.481585960549025 0.323876872585724 no 2269 0.315050050756454 3331 551167 SGTC_2043 5101342 149 µM -0.481623598490353 0.3238633956828 no 2270 0.315036679564956 3260 678451 SGTC_375 3970-0961 9.27 µM -0.482592331334437 0.323516603963708 no 2271 0.314692612614092 3268 2898222 SGTC_274 sirtinol 40.1 µM -0.483075974843423 0.323343524224192 no 2272 0.31452089606736 3275 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_300 r073-0011 5.04 µM -0.486442658377706 0.322139762324 no 2273 0.313326675827647 3370 2735780 SGTC_455 paf C-16 10 µM -0.487204821726574 0.321867508079114 no 2274 0.313056594352659 3260 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2553 4-methylesculetin 85.09 µM -0.487959887405607 0.321597883472244 no 2275 0.312789126893747 3305 5319502 SGTC_3165 9101544 49.47 µM -0.488902716986083 0.321261342601123 no 2276 0.312455286032596 3339 5002184 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.489032923069938 0.321214877359852 no 2277 0.312409194228105 3299 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_773 4358-1457 44.6 µM -0.489201391815778 0.32115476188802 no 2278 0.312349562134228 3371 1186886 SGTC_2205 7238770 200 µM -0.489442747104924 0.321068646144662 no 2279 0.312264139295469 3367 279867 SGTC_1341 1486-1360 280 µM -0.490747363288601 0.320603324818412 no 2280 0.311802571476856 3229 3976547 SGTC_969 1313-0238 134 µM -0.491206334980254 0.320439688991396 no 2281 0.311640259403458 3233 5212874 SGTC_1354 1498-1681 81 µM -0.491378183766627 0.320378429227733 no 2282 0.311579495715991 3339 5754243 SGTC_2856 9022925 19.48 µM -0.492276787175657 0.320058179484478 no 2283 0.31126184382718 3359 4944862 SGTC_3071 9117417 49.47 µM -0.494163698733204 0.319386146889183 no 2284 0.310595287315042 3240 45595590 YGL055W OLE1 SGTC_3058 9093861 49.47 µM -0.494642560497213 0.319215692210574 no 2285 0.310426226890081 3406 17217477 SGTC_3236 9132701 49.47 µM -0.494693083235141 0.31919771046525 no 2286 0.310408392353574 3323 24282524 SGTC_711 k292-0785 179 µM -0.495916305838556 0.318762478422867 no 2287 0.309976730652155 3292 4146315 SGTC_879 0831-1030 162 µM -0.496699349710372 0.31848399649566 no 2288 0.309700540539538 3353 1549252 SGTC_1866 st057638 64 µM -0.498333353569714 0.317903209241858 no 2289 0.309124551426049 3292 688802 SGTC_2035 5154463 94.595 µM -0.49999059549011 0.317314619476907 no 2290 0.308540849735619 3398 2769623 SGTC_1867 st057372 64 µM -0.500695150873871 0.317064527782477 no 2291 0.308292842753754 3364 688837 SGTC_2119 5528445 120.635 µM -0.50129210852229 0.316852694763804 no 2292 0.308082779158928 3400 791935 SGTC_834 0312-0008 75.7 µM -0.503507474899741 0.316067087552332 no 2293 0.307303763135576 3344 6385573 YIL048W NEO1 SGTC_2449 5812982 45.77 µM -0.504015400128666 0.315887085293623 no 2294 0.307125277537414 3356 776185 SGTC_1472 k841-0093 193 µM -0.504708595096338 0.315641496228141 no 2295 0.306881761637494 3417 X1472 SGTC_2026 5148700 152 µM -0.505863077867039 0.315232660177373 no 2296 0.306476386768179 3279 79838 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.505981563656232 0.315190713690061 no 2297 0.30643479610081 3241 688667 SGTC_2317 5986382 200 µM -0.506559390208089 0.314986184961829 no 2298 0.306232004207138 3358 877883 SGTC_819 1013-0258 27.7 µM -0.507161802183217 0.314773014313298 no 2299 0.306020647094694 3319 5753198 SGTC_2083 5306046 65.942 µM -0.507234102687148 0.314747434065436 no 2300 0.305995284696673 3325 539837 SGTC_364 0083-0097 67.7 µM -0.507536472605604 0.314640463843701 no 2301 0.305889225996902 3396 5207356 SGTC_19 0279-0214 38.434 µM -0.50810310473016 0.314440046761663 no 2302 0.305690519018181 3374 3566274 YBR002C RER2 SGTC_700 3453-2283 142 µM -0.509421225009886 0.313974040855812 no 2303 0.305228500989651 3433 565664 SGTC_1470 k295-0292 231 µM -0.509853824448623 0.313821165005785 no 2304 0.305076936914501 3382 5045612 SGTC_1507 4075-3230 155 µM -0.510500456015587 0.31359271216163 no 2305 0.30485044759694 3343 659771 SGTC_256 clotrimazole 625 nM -0.514331181653057 0.312240797457846 no 2306 0.303510232291261 3348 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3059 1327-0034 3 µM -0.517007233814441 0.311297878754218 no 2307 0.302575554562076 3317 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2065 5221596 34.26 µM -0.51762985687076 0.311078671916926 no 2308 0.302358273114649 3392 788581 SGTC_605 1315-0399 119 µM -0.51774154030481 0.311039358626415 no 2309 0.302319305511489 3428 24020461 SGTC_2474 5321570 43.32 µM -0.518520665684759 0.310765161464356 no 2310 0.302047522631789 3361 2841384 SGTC_1735 st034310 56.75 µM -0.519649705357576 0.310368005616629 no 2311 0.301653873723471 3426 871153 SGTC_423 5-fluorouracil 457 µM -0.520330580025368 0.310128605011917 no 2312 0.301416592786722 3225 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1724 st037281 8.293 µM -0.520900711658253 0.309928204367765 no 2313 0.301217969817499 3323 574124 YDL195W SEC31 SGTC_1323 1348-1351 11.2 µM -0.521455687046735 0.309733185353453 no 2314 0.301024683641593 3321 6989654 SGTC_3195 9113082 49.47 µM -0.521588449807519 0.309686540295252 no 2315 0.300978453471639 3402 17018038 SGTC_1359 1582-0056 520 nM -0.521751227572924 0.309629353904739 no 2316 0.30092177595366 3418 3661189 SGTC_2156 5649887 115 µM -0.521901740597666 0.309576480411014 no 2317 0.300869373173315 3415 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_861 0443-0273 110 µM -0.522754667283299 0.309276931547045 no 2318 0.300572495059495 3372 6149169 SGTC_683 panaxydol 45 µM -0.52344621541396 0.309034152033381 no 2319 0.300331885106904 3401 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1539 benzyladenosine 56 µM -0.523709183729707 0.308941854495054 no 2320 0.30024041353692 3321 92208 A nucleotide analog. SGTC_2022 5136654 200 µM -0.52602315419805 0.308130209640773 no 2321 0.299436059752315 3387 1713771 SGTC_2403 6032726 181.2 µM -0.526246678886149 0.308051856039176 no 2322 0.299358412640086 3346 2881040 SGTC_3204 9114183 49.47 µM -0.526381464556847 0.308004612945757 no 2323 0.2993115957467 3307 17027248 SGTC_3212 9128307 49.47 µM -0.527068746509688 0.307763766456982 no 2324 0.299072924658546 3198 27243542 SGTC_655 k060-0012 42 µM -0.527804348360618 0.307506078812038 no 2325 0.298817569385364 3316 5994525 SGTC_1942 st076330 65.2 µM -0.530562893380923 0.306540583426492 no 2326 0.297860857544511 3468 24208414 SGTC_578 3460-0051 92 µM -0.530641257818258 0.306513175303132 no 2327 0.297833699795938 3468 2876744 SGTC_3010 9080089 71.4286 µM -0.532016210304898 0.306032459025952 no 2328 0.297357384151622 3405 17027233 SGTC_420 mitomycin C 81.9 mM -0.532644964115189 0.305812742848469 no 2329 0.297139685165838 3336 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3225 9130819 49.47 µM -0.53590122278195 0.304675972196876 no 2330 0.296013409667174 3444 4547121 SGTC_842 0271-0008 11.1 µM -0.53599939507464 0.304641729121022 no 2331 0.295979484262864 3459 1221709 SGTC_312 4092-0653 6.84 µM -0.537127423758511 0.304248388943173 no 2332 0.295589799487666 3402 1148278 SGTC_1437 4092-1038 11.6 µM -0.537435325847734 0.304141063730116 no 2333 0.295483473719434 3360 3977136 SGTC_1907 st060210 83.7 µM -0.538337571460073 0.303826665804738 no 2334 0.295172008615095 3486 688793 SGTC_2544 sphondin 68.51 µM -0.538540390213474 0.303756011226512 no 2335 0.295102014166203 3466 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_738 1315-0003 72.4 µM -0.538908294485491 0.303627865654112 no 2336 0.294975066835925 3455 6251474 SGTC_1324 1418-0026 34.4 µM -0.539212000729815 0.303522099231164 no 2337 0.294870290339564 3409 1372513 SGTC_2619 obliquin 87.91 µM -0.54072907479337 0.302994021147834 no 2338 0.294347167606087 3414 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3106 9121286 49.47 µM -0.544014415629799 0.301851839134945 no 2339 0.293215776439605 3494 15943471 SGTC_481 bay k-8644 50 µM -0.545453594107726 0.301352104366437 no 2340 0.292720794356382 3372 2303 A calcium channel antagonist. SGTC_840 0245-0196 390 µM -0.546109657723105 0.301124419046948 no 2341 0.292495280766763 3495 3827528 SGTC_1698 5-fluorocytosine 1.055 µM -0.546198072716861 0.301093740761436 no 2342 0.292464895403762 3459 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1497 4476-2978 41.3 µM -0.547869088856421 0.300514195696603 no 2343 0.291890897523618 3446 1528379 SGTC_2847 9005661 71.43 µM -0.549617093015897 0.2999084892191 no 2344 0.291291016210806 3373 2991449 SGTC_150 3970-0969 77.2 µM -0.551480891527705 0.299263267875191 no 2345 0.290652031092954 3448 6615640 SGTC_514 4466-0038 2.65 nM -0.553602061112495 0.298529715434847 no 2346 0.289925607575937 3392 5722064 SGTC_937 3122-0005 46.7 µM -0.553924469085793 0.298418290501947 no 2347 0.289815269140497 3459 759535 SGTC_801 0866-0028 10.1 µM -0.553958533900168 0.298406518729776 no 2348 0.289803612210085 3438 6849771 SGTC_3149 9097855 49.47 µM -0.554864371078755 0.298093566288504 no 2349 0.289493716758049 3440 25236625 YMR079W SEC14 SGTC_2484 5809818 12.04 µM -0.555821362292758 0.297763103474984 no 2350 0.289166490189467 3409 2870548 SGTC_2293 7624732 200 µM -0.556007285763113 0.297698920822004 no 2351 0.289102937060208 3417 894453 SGTC_1373 2887-0003 58.5 µM -0.556316311879175 0.297592255864365 no 2352 0.288997319010479 3372 776948 SGTC_934 2950-0684 338 µM -0.559019335852821 0.296660011512376 no 2353 0.28807426202532 3489 1121253 SGTC_2635 hydroquinidine 100 µM -0.560643000238592 0.296100670629427 no 2354 0.287520465817376 3427 442912 An experimental heart treatment. SGTC_2713 st079149 53.4 µM -0.561338551252996 0.295861206386787 no 2355 0.287283382771175 3440 3103253 SGTC_3161 9100388 49.47 µM -0.561415942740007 0.295834567552227 no 2356 0.287257009104247 3463 25236368 SGTC_3184 9108758 49.47 µM -0.563441487714903 0.295137749165817 no 2357 0.286567146546 3438 902885 SGTC_965 1291-5240 308 µM -0.563610238896042 0.295079730304886 no 2358 0.286509708546542 3480 2834598 SGTC_1732 st034308 51.822 µM -0.564111547419429 0.294907404873827 no 2359 0.2863391099117 3387 830119 SGTC_2212 7123476 200 µM -0.564812263498614 0.294666610597761 no 2360 0.286100732396829 3420 1085715 SGTC_2027 5150920 200 µM -0.565780707531833 0.294333963570872 no 2361 0.285771431446251 3408 786715 SGTC_1663 st014140 55.4 µM -0.565788168721128 0.294331401429627 no 2362 0.28576889511087 3523 4207120 SGTC_1754 st042065 16.137 µM -0.566110994693027 0.29422055420381 no 2363 0.285659164826925 3454 1126236 YIL048W NEO1 SGTC_192 3455-0609 60.9 µM -0.567299304388031 0.293812696172696 no 2364 0.285255424782858 3507 3769639 SGTC_131 0141-0277 33.849 µM -0.568391386182472 0.293438096814302 no 2365 0.284884619039794 3460 1547771 SGTC_1371 2421-0008 32.7 µM -0.568644744735942 0.293351222908632 no 2366 0.28479862648138 3397 2827552 SGTC_1667 st014849 34.6 µM -0.569765564307871 0.292967049068547 no 2367 0.284418357200833 3485 5348460 SGTC_1503 4585-0012 61.3 µM -0.569857908279656 0.292935407518901 no 2368 0.284387037754666 3507 2922052 SGTC_766 1391-0721 126 µM -0.57106701552574 0.292521254796063 no 2369 0.283977108223958 3491 1020919 YIL115C NUP159 SGTC_148 3253-0744 288.01 µM -0.573286366918874 0.291761774460965 no 2370 0.283225407318531 3481 6893655 SGTC_1897 st060201 15 µM -0.575062863408938 0.291154505625802 no 2371 0.282624391308 3445 611878 SGTC_2778 tioconazole 65.09 nM -0.576007321095529 0.290831897333472 no 2372 0.282305116561347 3445 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1527 coumarin 137 µM -0.576089238386253 0.290803923864819 no 2373 0.282277432530456 3509 323 A hepatotoxic, DNA x-linker. SGTC_18 0111-0177 500 nM -0.576118158943732 0.290794048248961 no 2374 0.282267659110957 3525 721752 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.576273818190146 0.290740897370742 no 2375 0.282215058388331 3433 688761 SGTC_1348 1493-0373 93.8 µM -0.576329778072408 0.290721790609413 no 2376 0.282196149452015 3432 3010129 SGTC_1705 st027868 56.3335 µM -0.576577760290099 0.290637127430191 no 2377 0.28211236319205 3478 292948 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.576626965155628 0.290620329853725 no 2378 0.282095739667464 3403 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2433 5607874 27.82 µM -0.577818729593526 0.290213623626086 no 2379 0.281693254385979 3460 2252428 SGTC_609 0986-0026 86.3 µM -0.579715681212367 0.289566813000484 no 2380 0.281053183394984 3474 2848610 SGTC_2085 5307070 144.047 µM -0.582121596647177 0.288747434082145 no 2381 0.280242389550403 3426 2840351 SGTC_768 0384-0033 77.3 µM -0.582218847145216 0.288714336598093 no 2382 0.280209639958972 3392 3965305 YMR134W ERG29 SGTC_2307 7538926 6.34 µM -0.585005246652752 0.287766794658299 no 2383 0.279272094463519 3437 96582 SGTC_283 0987-0079 11.7 µM -0.586039182194716 0.287415569035013 no 2384 0.278924592255036 3515 411556 SGTC_1873 rapamycin 2 nM -0.586297446072294 0.287327869024926 no 2385 0.278837823493889 3489 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_310 1273-0058 1.06 µM -0.58646327001292 0.287271566001016 no 2386 0.278782118648678 3521 2734232 SGTC_694 1315-0438 43.2 µM -0.587156713258053 0.287036174366624 no 2387 0.278549230598069 3414 6793154 SGTC_2864 9034755 47.6 µM -0.588408418039794 0.286611510396286 no 2388 0.278129094383814 3506 4930451 SGTC_1028 k015-0029 4.8 µM -0.588790220033185 0.286482036350713 no 2389 0.278001003631397 3504 4588309 SGTC_577 r071-0003 38.6 µM -0.589128376175086 0.286367386363718 no 2390 0.277887579668344 3500 4568517 YMR134W ERG29 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.589686172689107 0.286178316119161 no 2391 0.27770053354854 3420 6708514 SGTC_3235 9132602 49.47 µM -0.590133942776447 0.286026583256257 no 2392 0.277550427141026 3545 4912240 SGTC_3325 9138760 55.175 µM -0.592399199427519 0.285259557366127 no 2393 0.276791651153744 3422 43844959 SGTC_3152 9099253 49.47 µM -0.592809343180676 0.285120785735291 no 2394 0.276654377107308 3513 25236131 SGTC_783 0848-0141 92.7 µM -0.593323677496489 0.284946806849786 no 2395 0.27648227791833 3503 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_184 1494-0393 24.714 µM -0.59369048711196 0.284822760654784 no 2396 0.276359573410544 3462 3090647 SGTC_2775 cyproheptadine 69.59 µM -0.593896739713181 0.284753022301871 no 2397 0.276290589887812 3556 2913 A selective serotonin reuptake inhibitor. SGTC_46 0329-0187a 2.197 µM -0.594935003752175 0.284402087162452 no 2398 0.275943459062296 3478 46494817 SGTC_2096 5468907 200 µM -0.595262558775894 0.28429141586471 no 2399 0.275833989533303 3492 759785 SGTC_1094 duloxetine 25.4 µM -0.595338134253502 0.284265884036071 no 2400 0.275808735090934 3500 60834 A selective serotonin reuptake inhibitor. SGTC_596 1155-0152 116 µM -0.598285352882262 0.28327107457846 no 2401 0.274824774081184 3518 280313 SGTC_993 3909-8757 62.7 µM -0.599960084985628 0.28270652748041 no 2402 0.274266418574154 3451 4288324 YLR208W SEC13 SGTC_1444 4112-3581 28 µM -0.6005551851898 0.282506051279433 no 2403 0.274068147204757 3542 2877249 SGTC_400 oxethazaine 37.5 µM -0.600630524445974 0.282480676012737 no 2404 0.274043051243996 3484 4621 A local anesthetic. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.600897065130155 0.282390910353137 no 2405 0.273954274050289 3483 2724278 An inhibitor of dopamine biosynthesis. SGTC_2676 harmalol 100 µM -0.601064251981826 0.28233461211344 no 2406 0.273898596075152 3546 5459187 A monoamine oxidase inhibitor SGTC_732 3970-1727 52.7 µM -0.603086894474133 0.281653938818131 no 2407 0.273225442189205 3521 1275699 SGTC_2462 5162487 171.77 µM -0.604436265688133 0.281200279779257 no 2408 0.272776815375928 3508 2259986 SGTC_1653 st012112 65 µM -0.604525117144403 0.281170420277594 no 2409 0.272747287671432 3545 720429 SGTC_273 hydroxyurea 18.1 mM -0.605300272940618 0.280909985685367 no 2410 0.272489750052304 3555 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1418 3966-3099 2.4 µM -0.605343266987416 0.280895544084114 no 2411 0.272475469253362 3538 740335 SGTC_547 1120-0019 610 nM -0.605482552920984 0.280848760724789 no 2412 0.272429206925963 3500 3676939 SGTC_1995 st072814 61.1 µM -0.605987523305458 0.280679182864162 no 2413 0.272261519149843 3431 5769371 SGTC_3320 9137005 35.139 µM -0.606296612969692 0.280575409607839 no 2414 0.272158903672648 3488 4908713 SGTC_403 arphamenine a 50 µM -0.606461476375814 0.280520066231868 no 2415 0.272104178106836 3494 5487158 An arginine aminopeptidase inhibitor. SGTC_1799 st045822 46.1415 µM -0.606636365465303 0.280461363086855 no 2416 0.272046130547221 3522 3674992 SGTC_1510 1123-0200 71.5 µM -0.607001257130043 0.280338902965366 no 2417 0.271925038929659 3623 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1852 st056254 31.4 µM -0.610074703332654 0.279308462405096 no 2418 0.27090616150634 3467 442583 SGTC_1252 0493-0875 34.8 µM -0.611070031523548 0.27897515164275 no 2419 0.270576609341736 3515 3960963 SGTC_2738 aclarubicin 5.55 µM -0.61144841742181 0.278848490352081 no 2420 0.270451378707261 3448 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3030 9087619 49.47 µM -0.613407202826115 0.27819325223897 no 2421 0.269803562306506 3491 25236973 SGTC_1622 st003707 19.4 µM -0.61393526513165 0.278016737397613 no 2422 0.269629052742623 3543 10140899 SGTC_3254 9136651 49.47 µM -0.615298006670953 0.277561467832308 no 2423 0.269178966866015 3504 16454030 SGTC_2756 carbadox 75.1 µM -0.616288388296016 0.277230826343267 no 2424 0.268852100585524 3513 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2667 digitoxin 100 µM -0.616973835151067 0.277002100995902 no 2425 0.268625991975444 3514 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1024 4507-0395 26 µM -0.617774966066948 0.276734890403809 no 2426 0.268361843791301 3592 4201836 SGTC_2928 9011484 9.79 µM -0.61923515501107 0.276248181556683 no 2427 0.267880727852968 3530 2994751 SGTC_3295 9122362 53.5725 µM -0.620610608111869 0.275790101301039 no 2428 0.26742792912737 3538 4730473 SGTC_1113 artemisinin 1.17947 µM -0.621740400052439 0.275414115363448 no 2429 0.267056290963904 3555 2240 An anti-malaria and mitochondrial poison. SGTC_398 bronopol 33.3 µM -0.622502803680594 0.275160535982215 no 2430 0.266805650394264 3497 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2626 ethyl orsellinate 100 µM -0.622893535878231 0.275030621009215 no 2431 0.26667724307845 3527 75653 A natural product. SGTC_38 0929-0051 58.268 µM -0.624352624805008 0.274545754199512 no 2432 0.266198015288941 3530 1379719 SGTC_86 0417-1630 471.922 µM -0.624624681051266 0.274455394422931 no 2433 0.266108708522348 3595 3634867 SGTC_1177 0983-0204 23.6 µM -0.625111365971989 0.274293785275973 no 2434 0.265948984355383 3587 766818 SGTC_3321 9137793 26.8275 µM -0.625433371100975 0.274186885721605 no 2435 0.2658433328312 3559 4904192 SGTC_2363 9053361 176 µM -0.62635409598359 0.27388133622618 no 2436 0.265541355715657 3619 6469797 YMR079W SEC14 SGTC_382 3229-0966 23.2 µM -0.626745944646454 0.273751349379139 no 2437 0.265412890946077 3592 5722370 SGTC_2000 st075254 36.4 µM -0.627191292229478 0.273603652543053 no 2438 0.265266925240581 3538 17234175 SGTC_2620 irigenin 100 µM -0.628449247772832 0.273186672298926 no 2439 0.26485484199611 3582 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1356 1502-0781 85.8 µM -0.628856851628522 0.273051629568696 no 2440 0.264721388256908 3540 567702 SGTC_3178 9107506 49.47 µM -0.629297211415566 0.272905771706042 no 2441 0.26457724832217 3595 8897194 SGTC_2744 captopril 92.04 µM -0.62930250199291 0.272904019573181 no 2442 0.264575516836705 3525 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_284 0988-0104 32.6 µM -0.631377874876378 0.272217128426925 no 2443 0.263896739529903 3577 4666532 SGTC_888 0916-0002 6.97 µM -0.632979292426335 0.271687691361102 no 2444 0.263373582845721 3612 2802138 YIL048W NEO1 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.633132381270946 0.27163710623959 no 2445 0.263323598990559 3571 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_464 bw-b 70c 158 µM -0.6335499878624 0.271499140410056 no 2446 0.263187274124952 3595 5353454 SGTC_3247 9135149 49.47 µM -0.63382263893893 0.271409082766562 no 2447 0.263098288471212 3544 8934436 YOR116C RPO31 SGTC_572 0960-0087 17.7 µM -0.641346260828066 0.268929890467738 no 2448 0.260648869705621 3537 6796365 SGTC_2222 6885208 172.143 µM -0.642663675471718 0.26849694719346 no 2449 0.26022117795536 3554 609514 SGTC_791 1348-1292 225 µM -0.643229857709448 0.268310989878551 no 2450 0.260037481042307 3589 5437054 SGTC_251 melphalan 456.522 µM -0.645442123390754 0.267585013353945 no 2451 0.259320356605412 3636 460612 A DNA alkylator. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.64598711609687 0.267406320836185 no 2452 0.259143849667161 3656 6710655 SGTC_2836 9010338 19.48 µM -0.647756785847331 0.266826495868029 no 2453 0.258571134812545 3497 2994051 SGTC_831 k061-1017 217 µM -0.648345472303485 0.266633756098665 no 2454 0.258380764719652 3627 1240153 SGTC_2114 5491910 81.25 µM -0.648355599739319 0.266630440926391 no 2455 0.258377490333496 3629 2849228 SGTC_863 0466-0191 129 µM -0.648617838552378 0.266544605443362 no 2456 0.25829271119184 3588 765160 YPR165W RHO1 SGTC_59 0330-0160 1.33 µM -0.648941604331841 0.266438650357788 no 2457 0.258188060898466 3592 4293482 SGTC_1917 st066507 28.5 µM -0.649738392497726 0.266177985476381 no 2458 0.257930609981339 3541 3156428 SGTC_2176 5809774 33.9695 µM -0.655384339989843 0.264334651060799 no 2459 0.256110165729701 3593 2870539 SGTC_2296 7971656 126.45 µM -0.65627005943758 0.264046065098845 no 2460 0.255825189138638 3605 666570 SGTC_1990 st072050 59.8 µM -0.65650976144063 0.26396799277309 no 2461 0.255748094471808 3608 17233948 SGTC_1116 jasmonic acid  1.58368 µM -0.657067489229364 0.263786383159177 no 2462 0.255568761040148 3651 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2054 5233173 129 µM -0.658828966269104 0.263213222464856 no 2463 0.255002802162358 3603 6889 SGTC_1805 st050013 60.3 µM -0.659901446505324 0.262864563806564 no 2464 0.254658537948923 3574 4037144 SGTC_2954 9074818 52.69 µM -0.661119326898077 0.262468922744052 no 2465 0.254267895890061 3608 16648742 SGTC_2759 disulfiram 3.38 µM -0.661751387607584 0.262263711503999 no 2466 0.254065282731051 3584 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2729 fluphenazine 10.66 µM -0.662711858259806 0.261952032776177 no 2467 0.253757556812778 3561 3372 An atypical antipsychotic. SGTC_1108 betulinic acid 729.144 nM -0.663130133103708 0.261816359362712 no 2468 0.25362360661437 3626 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_289 k017-0060 526 µM -0.665277584129109 0.261120370986534 no 2469 0.252936482577352 3596 5512909 SGTC_1784 st039334 36.3 µM -0.666953592274819 0.260577838616697 no 2470 0.252400888500688 3678 3496984 SGTC_2611 pyromycin 23.93 µM -0.66997774493875 0.259600375308948 no 2471 0.251435988662735 3616 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1407 3909-7909 12.3 µM -0.67000016567417 0.259593135579222 no 2472 0.251428842288802 3640 4411780 SGTC_214 4373-3496 70 µM -0.670105456226596 0.259559138305384 no 2473 0.251395283466913 3694 3779166 SGTC_139 0099-0334 718.624 µM -0.670398390925815 0.259464564696965 no 2474 0.251301930060609 3673 97690 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.671180567352104 0.259212127232549 no 2475 0.251052753303066 3625 4330530 SGTC_540 1187-0821 17.3 µM -0.674490759476595 0.258145212077688 no 2476 0.249999679274407 3630 847520 SGTC_299 1273-0059 1.44 µM -0.67461536755281 0.258105093894525 no 2477 0.249960083438056 3602 2848077 SGTC_1635 st007035 42.4 µM -0.674956715412553 0.257995211832559 no 2478 0.249851632765679 3651 3716403 SGTC_841 0251-0215 91.2 µM -0.676606186746481 0.257464578573903 no 2479 0.249327926360276 3669 3888614 SGTC_3145 9085516 49.47 µM -0.677309104514451 0.257238623051789 no 2480 0.249104927749752 3640 25236195 SGTC_263 alizarin 107.927 µM -0.677449244176593 0.257193586965873 no 2481 0.24906048153924 3653 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_212 3807-4682 38.772 µM -0.677533094020336 0.257166642459268 no 2482 0.249033890030374 3731 3125501 YBL034C STU1 SGTC_3279 9140807 49.47 µM -0.677886828231031 0.257052988832043 no 2483 0.248921726053236 3670 45595718 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.6784634043879 0.256867792839059 no 2484 0.248738959778699 3582 1241132 A phosphatase inhibitor. SGTC_330 1488-0319 80.1 µM -0.678605557918408 0.256822143863441 no 2485 0.248693910155517 3641 6846614 SGTC_1062 mesoridazine 14.2 µM -0.679871613457792 0.256415768800368 no 2486 0.248292878496486 3641 4078 A neuroleptic. SGTC_1173 0443-0020 122 µM -0.68041156889673 0.256242557349904 no 2487 0.248121948895105 3647 5331295 SGTC_2472 5377652 49.4 µM -0.681746061604051 0.2558147293719 no 2488 0.247699768054355 3657 1610903 SGTC_1199 1638-0010 4.46 µM -0.682660471185731 0.255521792193448 no 2489 0.247410706576709 3632 3111136 SGTC_1986 st071812 45 µM -0.682786172731778 0.255481536574179 no 2490 0.247370984134843 3624 11838594 SGTC_1833 st055984 71 µM -0.683352019351781 0.255300366586716 no 2491 0.247192215430321 3664 676288 SGTC_1847 st056231 15 µM -0.683495922478449 0.255254303105362 no 2492 0.247146762938437 3659 5393180 SGTC_2524 avocatin b 10.57 µM -0.68395503118571 0.255107371170262 no 2493 0.247001781138728 3593 6710748 SGTC_304 1310-0298 97 µM -0.685633096821763 0.254570704060085 no 2494 0.246472252658114 3596 1550234 SGTC_1670 st016595 4.04 µM -0.685966608700852 0.254464113138682 no 2495 0.246367082538119 3660 597879 SGTC_1045 1348-1485 165 µM -0.686987362989149 0.254138023841828 no 2496 0.246045345921794 3680 6810614 SGTC_1764 st044502 93.5 µM -0.687908266596131 0.253844020926729 no 2497 0.245755275255942 3659 8407 SGTC_2555 cholic acid 100 µM -0.688350242843379 0.253702981311401 no 2498 0.24561612467425 3671 6708657 Influences liver metabolism. SGTC_2098 5376439 882.5 nM -0.688848248291947 0.253544111465703 no 2499 0.24545938473113 3708 2844116 SGTC_1130 3454-2858 15.9 µM -0.689511981746807 0.253332453631991 no 2500 0.245250567894665 3656 715628 YIL048W NEO1 SGTC_2888 9058547 12.99 µM -0.689972717976557 0.253185584179322 no 2501 0.245105672086889 3591 16476514 SGTC_2279 7948423 32.93 µM -0.690075985558856 0.253152671589747 no 2502 0.245073202035476 3666 1247112 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.691960334668455 0.252552502805124 no 2503 0.244481119477623 3684 4174840 SGTC_2993 9054257 71.4286 µM -0.693700734576784 0.251998848757236 no 2504 0.243934952622518 3669 6470217 YGL055W OLE1 SGTC_120 rhodamine 6G 52.259 µM -0.694111497402182 0.251868270831433 no 2505 0.243806144407218 3707 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3050 9093513 49.47 µM -0.694714557973289 0.251676627856041 no 2506 0.243617101431547 3671 25236664 SGTC_301 4119-0100 24.5 µM -0.69580464229174 0.25133041206303 no 2507 0.24327559079877 3684 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.696859411381108 0.250995652383115 no 2508 0.242945390496654 3678 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2957 9076800 11.52 µM -0.696965877014383 0.250961875731036 no 2509 0.242912074419078 3630 16459615 SGTC_880 0833-0487 87.2 µM -0.698723735447467 0.250404535958351 no 2510 0.2423623488097 3664 76075 SGTC_2221 6807166 181.081 µM -0.699105956133803 0.250283437441795 no 2511 0.24224290827409 3626 674925 SGTC_3031 9088762 49.47 µM -0.699189738887601 0.250256896803379 no 2512 0.242216731179014 3661 205253 SGTC_343 4130-2827 29.8 µM -0.699463695500331 0.250170123450414 no 2513 0.242131146842423 3717 1118244 SGTC_981 1488-1094 54.9 µM -0.699847580816861 0.250048557997854 no 2514 0.242011248251391 3658 3449522 SGTC_708 3448-5400 146 µM -0.700156339868587 0.249950805621439 no 2515 0.241914837155522 3661 3462195 SGTC_390 dec-rvkr-cmk 16.7 µM -0.700974894008895 0.249691751525707 no 2516 0.241659341628903 3724 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2 0422-0095 29 µM -0.701285887760296 0.24959336634401 no 2517 0.241562309478382 3573 6790840 SGTC_1285 0929-0069 65.5 µM -0.703695903454515 0.248831638673257 no 2518 0.240811086021266 3692 1206237 SGTC_3245 9134821 49.47 µM -0.705698622237729 0.24819958708768 no 2519 0.240187788981477 3666 17014901 SGTC_2122 5258151 111.688 µM -0.706154183671749 0.248055932991092 no 2520 0.240046129522879 3687 2173356 SGTC_3261 9137475 49.47 µM -0.707876202141507 0.247513322666779 no 2521 0.239511069691931 3563 17027690 SGTC_1294 1000-1494 117 µM -0.708138481171017 0.247430733880817 no 2522 0.239429632407923 3680 712797 YDL207W GLE1 SGTC_1436 4092-1007 8.32 µM -0.708397499969979 0.247349186161915 no 2523 0.239349222264187 3666 2881121 SGTC_1937 st074714 47.2 µM -0.708576663677941 0.247292787883981 no 2524 0.239293611073572 3656 17250970 SGTC_2797 7859098 81.82 µM -0.709462289449516 0.24701410605182 no 2525 0.239018822597676 3720 972681 SGTC_646 4092-0839 27.3 µM -0.711277622131697 0.246443396888441 no 2526 0.23845610793287 3734 877796 SGTC_2643 anethole 100 µM -0.711487815984786 0.246377361254998 no 2527 0.238390999179909 3692 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1941 st076221 61.8 µM -0.712001693014975 0.246215958821248 no 2528 0.23823186382011 3675 2828568 SGTC_600 1495-0418 41.6 µM -0.712022022415552 0.246209574773445 no 2529 0.238225569490497 3702 5377768 SGTC_2262 9014885 67.46 µM -0.713661080722569 0.24569515298847 no 2530 0.237718388955113 3634 6457424 SGTC_1638 st008370 60.6 µM -0.713843415295753 0.245637962606027 no 2531 0.237662005055833 3702 24207134 SGTC_1102 cgs 12066b 26.1 µM -0.71444894139629 0.245448086853966 no 2532 0.237474808953097 3698 6438352 A 5-HT1B full agonist. SGTC_2171 5739187 198.077 µM -0.714456553540811 0.245445700404135 no 2533 0.237472456202671 3639 2262761 SGTC_556 4058-0063 51.5 µM -0.71540498373559 0.245148459814501 no 2534 0.237179416929611 3759 6615692 SGTC_1708 st033234 31.827 µM -0.716428284652809 0.244827971769311 no 2535 0.236863467551028 3780 674664 SGTC_296 1222-0039 74.9 µM -0.71774541906235 0.244415790057041 no 2536 0.236457136424807 3663 5984176 SGTC_1461 k072-0203 53.8 µM -0.717755944986636 0.244412497599641 no 2537 0.23645389076182 3643 5418714 SGTC_2008 4012253 172 µM -0.718559366386715 0.244161261876846 no 2538 0.236206228591012 3721 603940 SGTC_2926 9010726 65.15 µM -0.719996351712969 0.243712253589708 no 2539 0.235763620910487 3711 2994293 SGTC_1210 3013-0140 750 nM -0.721420279642897 0.243267765386605 no 2540 0.235325486530153 3737 905973 SGTC_2862 9027634 71.43 µM -0.722806252142835 0.242835546384358 no 2541 0.234899462828527 3642 5012562 SGTC_1522 st012842 45.6 µM -0.723373804562251 0.242658673742715 no 2542 0.234725130226599 3625 3491067 YOR116C RPO31 SGTC_1179 1021-1431 9.29 µM -0.723593153713023 0.242590334231494 no 2543 0.234657772875166 3729 2840958 SGTC_2783 7738165 71.43 µM -0.724452037376312 0.242322844330066 no 2544 0.23439413128366 3685 17201110 SGTC_1278 0874-0585 172 µM -0.725166077741051 0.242100586016377 no 2545 0.234175075401764 3771 766306 SGTC_2355 9061122 103.12 µM -0.726019611349193 0.241835052943853 no 2546 0.233913374074113 3727 5302957 SGTC_623 k072-0108 16.9 µM -0.727016440782082 0.241525140904358 no 2547 0.233607942155599 3710 5382803 SGTC_736 0958-0254 92.6 µM -0.727562702652289 0.24135540083596 no 2548 0.23344065950891 3774 6812352 SGTC_2767 sibutramine 71.45 µM -0.72783833805297 0.241269777197218 no 2549 0.233356276469881 3750 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3006 9075424 71.4286 µM -0.729836254871994 0.240649636200377 no 2550 0.232745140291208 3719 7465181 SGTC_2173 5763948 167 µM -0.729880747273938 0.240635835917766 no 2551 0.232731540789095 3733 2867177 SGTC_3159 9100096 49.47 µM -0.729951421325935 0.240613915714707 no 2552 0.232709939538487 3695 25236875 SGTC_279 1273-0055 2.93 µM -0.731480495144462 0.24013992577523 no 2553 0.232242856992848 3761 2847562 SGTC_2751 anetholtrithion 17.25 µM -0.732255477059987 0.239899887494522 no 2554 0.232006324456021 3722 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2218 6965428 192.983 µM -0.732955895089537 0.239683056822916 no 2555 0.23179266503567 3677 675684 SGTC_3181 9108277 49.47 µM -0.733323375660836 0.23956933746734 no 2556 0.231680610570219 3683 17097298 SGTC_1579 chlormadinone acetate 49.4 µM -0.734372072110435 0.23924497326093 no 2557 0.231361001561802 3730 45114258 A steroidal progestin. SGTC_2943 9068529 45.32 µM -0.734945961113294 0.239067569718206 no 2558 0.231186202774085 3751 3270634 SGTC_2391 6285546 200 µM -0.735342194517797 0.238945125970169 no 2559 0.231065558479841 3718 846083 SGTC_1050 3232-1156 69.3 µM -0.738089270118086 0.238097170472609 no 2560 0.23023010180222 3719 700529 SGTC_1487 3970-0795 2.82 µM -0.738239293319153 0.238050909493597 no 2561 0.230184524575903 3797 3765103 SGTC_1306 1185-0270 9.02 µM -0.739048988211059 0.237801317988969 no 2562 0.229938625455765 3743 1548076 SGTC_2552 juarezic acid 87.02 µM -0.739156539803858 0.237768175606733 no 2563 0.229905973796175 3781 1549512 SGTC_2784 7567673 72.73 µM -0.73941335698766 0.237689046783484 no 2564 0.229828016995733 3755 3471247 SGTC_2694 st077685 81.9 µM -0.740023748493754 0.237501034951989 no 2565 0.229642792189591 3723 2838096 SGTC_2880 9042983 58.44 µM -0.740883347573562 0.237236401077608 no 2566 0.229382086585046 3743 6464714 SGTC_2050 5263056 171 µM -0.741062633735797 0.237181226939256 no 2567 0.229327732260396 3762 763468 YGL055W OLE1 SGTC_967 1306-0166 352 µM -0.741787610292576 0.236958192069138 no 2568 0.229108014202375 3707 4437607 SGTC_1972 st070201 17.4 µM -0.742360831481314 0.236781925510206 no 2569 0.228934372143595 3706 2829099 SGTC_2707 st078556 66.6 µM -0.742445996601423 0.23675574323454 no 2570 0.228908579946353 3727 17250899 SGTC_88 0180-0332 8.668 µM -0.742992501072588 0.236587769500454 no 2571 0.228743110260836 3806 3101745 SGTC_1355 1499-0035 1.68 µM -0.744304327650559 0.236184833931987 no 2572 0.228346191855281 3746 1548538 SGTC_142 0335-0849 62.6745 µM -0.74456186471416 0.236105774255067 no 2573 0.228268314533234 3753 3889043 YPR107C YTH1 SGTC_337 1315-0038 354 µM -0.744857681122325 0.236014981437538 no 2574 0.228178880243614 3734 1626437 SGTC_1183 1254-0324 198 µM -0.746177383608234 0.23561016903587 no 2575 0.227780134157069 3806 5799357 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.746652255676754 0.235464598068325 no 2576 0.227636748291124 3724 7104 SGTC_2057 5236571 38.335 µM -0.748555616318483 0.234881625567503 no 2577 0.227062545895835 3736 54684039 YBR257W POP4 SGTC_463 ikarugamyin 104 µM -0.748937213275072 0.234764843873815 no 2578 0.226947524768041 3791 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2931 9014674 55.67 µM -0.749372313109043 0.23463172764819 no 2579 0.226816416881995 3766 2996810 SGTC_828 2074-0507 139 µM -0.749523787256911 0.234585394824242 no 2580 0.226770783466428 3803 X828 SGTC_3231 9132313 49.47 µM -0.750575574149813 0.2342638144652 no 2581 0.226454062870499 3758 4905967 SGTC_3095 9117207 49.47 µM -0.751187330574 0.234076884266781 no 2582 0.226269961932029 3746 17015229 SGTC_639 0833-0042 114 µM -0.751395361721037 0.234013336448566 no 2583 0.226207376662682 3745 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1519 esterone 74 µM -0.752274616423035 0.233744853793919 no 2584 0.225942964754235 3766 698 A steroid. SGTC_1875 nocodazole 6 µM -0.753512204436051 0.233367242617495 no 2585 0.225571090113964 3733 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3352 9151559 45.5865 µM -0.753577832425517 0.233347227748862 no 2586 0.225551379669069 3762 17159339 SGTC_557 1315-0110 16.2 µM -0.753764997502584 0.233290152389728 no 2587 0.225495172621096 3761 6833801 SGTC_665 3914-0008 307 µM -0.753818122622755 0.233273953475154 no 2588 0.225479220201796 3736 1069549 SGTC_2311 7694451 200 µM -0.754489545208911 0.233069277071455 no 2589 0.225277660387907 3726 2163142 SGTC_1159 4092-0538 61.2 µM -0.755238478067712 0.232841090139316 no 2590 0.225052952573178 3786 717301 SGTC_15 0266-0086 27.098 µM -0.75586072675562 0.232651596133688 no 2591 0.224866351378332 3840 1712902 YIL048W NEO1 SGTC_411 enrofloxacin 100 µM -0.756834859539142 0.232355114738111 no 2592 0.224574402684674 3810 71188 A bacterial gyrase inhibitor. SGTC_722 3534-0461 190 µM -0.759376599841762 0.231582515967298 no 2593 0.223813653674595 3776 658262 SGTC_823 0417-1665 178 µM -0.759823075840936 0.231446951128813 no 2594 0.223680173741576 3805 3429856 SGTC_438 sphingosine 6.67 µM -0.760019630882768 0.231387284566189 no 2595 0.223621425352206 3731 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1011 4112-3381 17.4 µM -0.761733758834067 0.230867304898177 no 2596 0.223109461260125 3854 2877139 SGTC_1085 doxorubicin 7.67 µM -0.761880311056322 0.230822878669655 no 2597 0.223065721028181 3768 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_974 1326-0144 138 µM -0.762860606045474 0.230525832262953 no 2598 0.22277326608111 3826 5411856 SGTC_821 1114-0266 29.2 µM -0.765639501171128 0.229684941109393 no 2599 0.221945416931258 3797 3123235 SGTC_2717 st081029 62.2815 µM -0.76624260637976 0.229502669170883 no 2600 0.221765980631588 3784 5292846 SGTC_215 1287-0124 461.5 µM -0.767643752098399 0.229079524514081 no 2601 0.221349430814047 3803 5560863 SGTC_2810 7959871 45.46 µM -0.768032282682171 0.228962266202319 no 2602 0.221234002954385 3791 2974535 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.770223611211464 0.228301555490313 no 2603 0.220583630140071 3824 115019 SGTC_709 3807-1509 243 µM -0.772008745934046 0.22776410988086 no 2604 0.220054623756651 3845 1886677 YPL242C IQG1 SGTC_2687 chenodiol 100 µM -0.772313777400657 0.227672346180528 no 2605 0.219964303668238 3817 5702181 A cholesterol synthesis inhibitor. SGTC_869 0564-0080 44.1 µM -0.772830588762027 0.227516919495707 no 2606 0.219811323925905 3807 6843321 SGTC_1416 3966-0321 25.3 µM -0.772988006534804 0.227469589295416 no 2607 0.219764739311692 3811 582530 YLR208W SEC13 SGTC_92 0063-0024 660.874 µM -0.773596684749365 0.227286632529553 no 2608 0.219584666607876 3866 3594437 SGTC_3094 9117742 49.47 µM -0.774371195656258 0.227053949631732 no 2609 0.21935565615937 3735 17149698 SGTC_158 k038-0087 26.446 µM -0.774398293031369 0.227045811319165 no 2610 0.219347646386022 3735 X158 SGTC_2115 tiliquinol 12.7705 µM -0.775242172483723 0.226792446418317 no 2611 0.21909828631661 3794 71208 A bioactive hydroxyquinoline. SGTC_1777 st045864 34.765 µM -0.775664463386122 0.226665718441078 no 2612 0.218973563730681 3780 4691462 SGTC_958 1222-0007 33 µM -0.775756713131261 0.226638039944938 no 2613 0.218946323429753 3860 7312461 SGTC_229 benomyl 22.8748 µM -0.777766841680831 0.226035397398118 no 2614 0.218353239499123 3810 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3119 9125183 49.47 µM -0.779095722794073 0.225637492732928 no 2615 0.21796166475828 3650 22695334 SGTC_1349 flufenamic acid 69 µM -0.779831497973853 0.22541735137685 no 2616 0.217745031838377 3756 3371 A non-steroidal anti-inflammatory. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.780114814209821 0.225332616587452 no 2617 0.217661648699372 3819 5282362 SGTC_2024 5144227 134 µM -0.782283862143466 0.224684491310307 no 2618 0.21702388438785 3863 3475211 SGTC_2319 6033012 152.6 µM -0.784230582099384 0.224103700442159 no 2619 0.216452411735801 3781 847246 SGTC_2485 5633444 17.78 µM -0.784287107840452 0.224086849114875 no 2620 0.216435831247055 3838 5724239 SGTC_1524 corynanthine 62.1 µM -0.785793379965619 0.223638067855126 no 2621 0.215994272786712 3928 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1162 k048-0130 20.1 µM -0.786894273925814 0.223310389180009 no 2622 0.215671879895677 3782 6797406 SGTC_724 3910-0327 137 µM -0.788387662591886 0.222866322352626 no 2623 0.215234992549275 3851 2885483 SGTC_2933 9026794 32.47 µM -0.788567503996697 0.222812879544785 no 2624 0.2151824150428 3816 17586027 SGTC_2689 tacrolimus 100 µM -0.78862240980006 0.222796564844578 no 2625 0.21516636455062 3828 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.790833430600402 0.222140148405628 no 2626 0.214520599405882 3844 23665772 A membrane-active detergent. SGTC_2239 6685329 187.64 µM -0.791657989225305 0.221895633108374 no 2627 0.214280062192126 3887 805680 SGTC_2269 7935389 174.42 µM -0.793404184399479 0.221378322693596 no 2628 0.21377118680299 3778 97605 SGTC_2753 fluvastatin 17.09 µM -0.794154180548896 0.221156348173405 no 2629 0.213552839520266 3862 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.796534127093137 0.220452805018167 no 2630 0.212860823902366 3819 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_61 0978-8327 98.565 µM -0.797039454082624 0.220303589046178 no 2631 0.212714058913577 3795 6150059 YHR072W ERG7 SGTC_1213 1315-0166 115 µM -0.797102940666512 0.220284846443721 no 2632 0.212695624322932 3897 768401 SGTC_1032 k061-1018 98.7 µM -0.797847594740456 0.22006507683608 no 2633 0.212479468870211 3962 4005393 SGTC_91 0417-1751 58.384 µM -0.799033897110212 0.219715223580515 no 2634 0.212135378567973 3921 6795624 SGTC_1964 st076914 61 µM -0.80143207569909 0.219008951210486 no 2635 0.211440776045911 3879 24208661 SGTC_396 dithiazanine 1.25 µM -0.804164189084391 0.218205927190437 no 2636 0.210651078784953 3832 10578 An antihelmenthic. SGTC_1087 pterostilbene 9.05 µM -0.806801414363248 0.21743240454115 no 2637 0.209890452079608 3895 5281727 Similar to reservatol, lowers cholesterol. SGTC_2700 st077718 96.8 µM -0.808323799166939 0.216986596597116 no 2638 0.209452102777738 3838 904970 SGTC_1730 st033808 45.1 µM -0.809730927049912 0.216575010137142 no 2639 0.209047419494418 3817 1045166 SGTC_2479 5617353 43.85 µM -0.810241694947178 0.216425721763145 no 2640 0.208900639060218 3868 2731746 SGTC_2859 9028643 45.46 µM -0.813190493953121 0.215565005460057 no 2641 0.20805442438213 3770 17151580 SGTC_2113 5491891 107.031 µM -0.813737223150642 0.215405640702201 no 2642 0.207897752554264 3872 789979 SGTC_681 1642-0006 26.6 µM -0.814967650407828 0.215047236577025 no 2643 0.207545413740584 3863 4446530 SGTC_2428 5615643 7.78 µM -0.816904108458052 0.214483878628396 no 2644 0.206991614870223 3895 2253075 SGTC_1205 4161-2785 76 µM -0.817372816351863 0.214347650356045 no 2645 0.206857702775239 3964 3498106 SGTC_1594 piperine 70.1 µM -0.820186333672358 0.213530969960741 no 2646 0.206054945772058 3840 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_414 piperonyl butoxide 100 µM -0.823518084563774 0.212566210697014 no 2647 0.205106718674574 3860 5794 A potent inhibitor of cytochrome P450. SGTC_3080 9117754 49.47 µM -0.824796752285715 0.212196630056663 no 2648 0.204743495412441 3880 9550191 SGTC_1410 3909-8106 77.9 µM -0.825754775820805 0.211919973357558 no 2649 0.204471606450225 3892 1039210 SGTC_3069 9117009 49.47 µM -0.826017190808772 0.211844230352116 no 2650 0.204397170069439 3817 41904981 SGTC_322 k048-0136 19.3 µM -0.826348991917697 0.211748482535341 no 2651 0.204303074784821 3920 6823282 SGTC_2671 danthron 100 µM -0.826674413671983 0.21165460021198 no 2652 0.204210813674339 3856 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2229 7354935 190 µM -0.826743120915015 0.211634781679039 no 2653 0.204191337490114 3790 318112 SGTC_779 1360-0071 233 µM -0.827715286308414 0.211354478023107 no 2654 0.203915879997609 3943 7566 SGTC_2966 9084041 48.03 µM -0.830548571569952 0.210538800614948 no 2655 0.203114348979308 3820 17741380 SGTC_2785 7756463 72.73 µM -0.83089778963333 0.210438391909979 no 2656 0.203015686224826 3842 2201551 SGTC_1216 1165-0504 9.65 µM -0.832129036514595 0.21008460275701 no 2657 0.202668056873859 3868 6304004 SGTC_2685 mycophenolic acid 18.85 µM -0.833307466661931 0.20974631757349 no 2658 0.202335673164081 3859 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_170 4197-0004 226 µM -0.833616231533793 0.209657735192034 no 2659 0.202248638002476 3919 218692 SGTC_329 k048-0121 21.3 µM -0.834845410752532 0.209305310862716 no 2660 0.201902376997623 3898 6832902 SGTC_1771 st048882 4.1505 µM -0.835238665401186 0.20919263245053 no 2661 0.201791671751931 3899 4580403 SGTC_992 3909-8734 162 µM -0.836253888060064 0.208901908024473 no 2662 0.201506044178886 3905 4288319 SGTC_2922 7999257 32.47 µM -0.83675005344659 0.208759910163599 no 2663 0.201366538821893 3851 2988377 SGTC_2837 9008476 45.46 µM -0.837103121306285 0.208658900115231 no 2664 0.201267303036959 3866 2992805 SGTC_548 1436-0017 110 µM -0.837401660179773 0.208573512880759 no 2665 0.20118341644117 3963 9677137 SGTC_2952 9073731 13.78 µM -0.837749153937991 0.20847414965947 no 2666 0.201085800395045 3945 16457353 SGTC_2580 diallyl disulphide 81.36 µM -0.838167641853504 0.20835452325257 no 2667 0.200968278772289 3906 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1846 st056244 14.8 µM -0.838532705359126 0.20825020149655 no 2668 0.200865793686365 3915 5393182 SGTC_3306 9127676 59.7925 µM -0.838682230814236 0.208207481505367 no 2669 0.20082382612924 3892 41905287 SGTC_1627 st003713 25.6 µM -0.839354313439795 0.208015528809545 no 2670 0.20063525657659 3958 16195070 YER133W GLC7 SGTC_2082 5219693 150 µM -0.839680784733825 0.207922323454131 no 2671 0.200543695282164 3877 2834649 SGTC_1945 st075991 56.6 µM -0.840834015150427 0.207593281395087 no 2672 0.20022046418365 3913 1084980 SGTC_1970 st070122 35.8 µM -0.841006879243784 0.207543985990135 no 2673 0.200172040280168 3904 102928 SGTC_2330 7979373 200 µM -0.842091989465787 0.207234704709425 no 2674 0.199868232385822 3844 1863007 SGTC_176 1486-1328 72.834 µM -0.84261987524196 0.207084343771676 no 2675 0.19972053586518 3951 22310231 SGTC_2329 6138490 200 µM -0.84482948177729 0.206455668859809 no 2676 0.199103025729782 4029 720019 SGTC_977 1348-1378 135 µM -0.845088020456098 0.206382183673698 no 2677 0.199030848174342 3886 X977 SGTC_1766 st045414 44.774 µM -0.845824010919981 0.206173075885045 no 2678 0.198825464320695 3928 253960 SGTC_336 4111-0029 111 µM -0.846191118628816 0.206068821119682 no 2679 0.19872306783886 3891 3131175 SGTC_3269 9137823 49.47 µM -0.846288827235577 0.206041078161535 no 2680 0.198695819567856 3799 17682936 SGTC_2710 st078562 53.7235 µM -0.846563791080082 0.205963018007782 no 2681 0.198619151727281 3861 17250908 SGTC_69 0096-0274 206.684 µM -0.846805821195484 0.205894322008071 no 2682 0.198551681525328 4028 6741392 SGTC_1275 0867-0008 21.1 µM -0.849221589811535 0.205209393717746 no 2683 0.197879000970066 3864 3422836 SGTC_2703 st077852 53.4 µM -0.849272591293309 0.205194948183046 no 2684 0.197864814256772 3942 6281836 SGTC_1475 4092-1048 11.7 µM -0.850407056890961 0.204873781152077 no 2685 0.197549407035913 3929 2881759 SGTC_940 3232-1287 54.8 µM -0.8512288177314 0.204641327574917 no 2686 0.197321128785334 3806 1585493 YIL048W NEO1 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.851986122414433 0.204427245871256 no 2687 0.197110897248722 3904 2724 A muscle relaxant with antifungal properties. SGTC_3327 9140648 26.9345 µM -0.853453152995188 0.204012911901936 no 2688 0.196704028082128 3931 8029710 SGTC_68 0986-0284 82.829 µM -0.853531675790801 0.203990748796737 no 2689 0.196682264766377 4001 423278 YIL048W NEO1 SGTC_1253 0550-0034 176 µM -0.856433001010093 0.203172854202001 no 2690 0.195879158648718 3931 5969915 SGTC_2015 5119600 184 µM -0.856650017703071 0.203111755161103 no 2691 0.195819167077996 3950 2828786 SGTC_2955 9076254 12.21 µM -0.863535672409003 0.201178863812659 no 2692 0.193921507509299 3874 16459619 SGTC_344 k064-0035 6.43 µM -0.866543480751258 0.200338006595081 no 2693 0.193096096376968 3890 5088750 SGTC_2168 5727979 200 µM -0.867610336990751 0.200040266293215 no 2694 0.192803842817173 3838 695210 SGTC_1198 1612-1005 86.7 µM -0.868910783477566 0.19967769516643 no 2695 0.192447965454331 4004 6998509 SGTC_1895 st058434 18.3 µM -0.869123368545972 0.199618462986205 no 2696 0.19238982810184 3945 5393175 SGTC_236 1509-0011 5.31 µM -0.87056387941013 0.199217374772885 no 2697 0.191996162990324 3990 3107280 SGTC_911 3456-4043 236 µM -0.871949515885605 0.198832023863584 no 2698 0.191617959572575 3985 914281 SGTC_1425 4048-4433 7.33 µM -0.872401225826691 0.198706498748153 no 2699 0.191494766012628 3975 23734946 SGTC_2398 5228213 48.84 µM -0.874921377144043 0.198007054424298 no 2700 0.190808343329209 3937 80771 YMR134W ERG29 SGTC_2455 5377712 9.75 µM -0.875139798215746 0.197946503807155 no 2701 0.190748922375333 3942 2243908 SGTC_1121 fusaric acid 630.51 nM -0.875943853313409 0.197723700303045 no 2702 0.190530278883446 3925 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2696 st077691 74.316 µM -0.876237185988472 0.197642455622372 no 2703 0.190450552422196 3980 757133 SGTC_259 usnic acid 108.925 µM -0.877208987341136 0.197373438900633 no 2704 0.190186567711819 4018 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.8781764795813 0.197105835139211 no 2705 0.189923976998988 3925 688751 SGTC_2860 9025725 38.96 µM -0.878317330710429 0.197066894702706 no 2706 0.189885766658812 3936 40546248 SGTC_490 phenamil 164 µM -0.878506650154056 0.197014561798955 no 2707 0.189834415196145 3915 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3303 9125618 40.5795 µM -0.880863760822777 0.196363698605509 no 2708 0.189195782014375 3979 22695467 SGTC_2143 5623677 140.463 µM -0.88283233349226 0.195821121510242 no 2709 0.188663433984136 3879 5375313 SGTC_984 1492-0255 2.91 µM -0.884083411367517 0.195476773328475 no 2710 0.188325593681901 3919 1585198 SGTC_429 1112-0049 25.5 µM -0.885343737804825 0.195130251669044 no 2711 0.187985633519443 3925 2836170 SGTC_2681 menadione 3.18 µM -0.887310555355791 0.194590229666586 no 2712 0.187455862123036 3972 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1903 st060211 78.3 µM -0.887598602270089 0.194511218083487 no 2713 0.187378352893886 4004 688960 SGTC_2612 dictamnine 15.46 µM -0.88874449880852 0.194197090806693 no 2714 0.18707020503896 3935 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2347 9049783 174.81 µM -0.889159424475134 0.194083422508855 no 2715 0.186958702979878 4002 6467988 YPL169C MEX67 SGTC_2489 cantharidin 73.42 µM -0.88974464718269 0.193923170494889 no 2716 0.186801507288159 3909 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1969 st069479 40.1 µM -0.89036714291758 0.193752800511249 no 2717 0.186634389565192 3965 3895485 SGTC_3046 9092212 49.47 µM -0.891847873379688 0.193347908315973 no 2718 0.186237238806697 4003 25236637 SGTC_728 3030-5151 22.5 µM -0.892260267223689 0.193235234978327 no 2719 0.186126722834205 3985 3125388 SGTC_1734 st037168 69.4 µM -0.894000721285782 0.192760153579364 no 2720 0.185660752619674 4031 708907 SGTC_991 3996-0057 64.7 µM -0.897614742906558 0.191775937622025 no 2721 0.184695488207079 4022 715343 SGTC_2518 prenyletin 46.28 µM -0.898094743320934 0.191645449723857 no 2722 0.184567520638383 3920 3873459 A coumarin with calcium channel inhibitory activity. SGTC_658 3253-0951 102 µM -0.900263312151536 0.191056603344977 no 2723 0.183990070169125 3974 1184878 SGTC_2365 9042475 200 µM -0.904418990251101 0.189931288237219 no 2724 0.182886636128124 4054 6464479 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.904774129389406 0.189835309547898 no 2725 0.182792529954698 4024 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_433 pimozide 108 µM -0.906633652658908 0.189333248196666 no 2726 0.182300279766947 3892 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1078 idebenone 36.1 µM -0.90752576700239 0.189092672485188 no 2727 0.18206441491658 4030 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3294 9122953 26.2835 µM -0.907862590334799 0.18900189060617 no 2728 0.181975412309558 3982 16459826 SGTC_870 0573-2213 57.6 µM -0.908013712093491 0.188961168433465 no 2729 0.181935488555592 3962 3916321 SGTC_3203 9113543 49.47 µM -0.909715038505614 0.188503091887161 no 2730 0.181486405572739 4077 17018012 SGTC_617 3770-0098 35 µM -0.909746895732256 0.188494520970046 no 2731 0.181478003146494 3907 5962639 SGTC_2950 9072895 21.46 µM -0.91013245412899 0.188390808803424 no 2732 0.181376330426778 3945 17332245 SGTC_3208 9114115 49.47 µM -0.91043621424305 0.188309124523305 no 2733 0.1812962532425 4013 650895 SGTC_1830 st055982 50.3 µM -0.910840053109176 0.188200561857057 no 2734 0.181189827603859 3879 455313 An antimicrobial agent. SGTC_3033 9090887 49.47 µM -0.911700939295091 0.187969261624576 no 2735 0.180963084696175 4013 19325384 SGTC_2679 rapamycin 1 nM -0.912460018170058 0.187765460328864 no 2736 0.180763303698592 3931 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2360 9040895 200 µM -0.91314975904661 0.187580393643087 no 2737 0.180581891629775 4028 4914414 SGTC_372 0155-0182 15.9 µM -0.913207172891106 0.187564993825091 no 2738 0.180566796087616 3909 771486 SGTC_806 3966-4455 5.86 µM -0.914191105326587 0.187301200153114 no 2739 0.180308218541666 3967 714982 SGTC_3282 9108498 15.4605 µM -0.914819148802864 0.1871329408063 no 2740 0.180143290206998 3982 16459645 SGTC_2467 5474540 200 µM -0.915917896182533 0.186838799939384 no 2741 0.179854979784136 3941 5413519 SGTC_2451 5856223 45.7 µM -0.916354918354779 0.186721886221015 no 2742 0.179740386128894 3969 2179896 SGTC_794 k038-0031 316 µM -0.919500820389277 0.185881620330514 no 2743 0.178916838357085 3989 6624242 SGTC_1525 8-methoxypsoralen 92.5 µM -0.920467950951875 0.185623773143549 no 2744 0.178664136761023 4063 4114 Related to psoralen; DNA damaging agent. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.921686164005457 0.185299300732964 no 2745 0.178346149812892 4047 688788 SGTC_1038 k292-0204 154 µM -0.926224342649487 0.184093654225772 no 2746 0.17716470224628 3956 4454212 SGTC_2346 9031566 143.75 µM -0.927474878809933 0.183762287572124 no 2747 0.176840014472713 3974 4771086 SGTC_2071 5230951 39.92 µM -0.927668424748698 0.183711035057956 no 2748 0.176789796058526 4036 1799272 SGTC_447 ml7 120 µM -0.929437578598702 0.183242961803368 no 2749 0.176331180282248 4027 4216 Selective myosin light chain kinase inhibitor. SGTC_1334 1486-0610 236 µM -0.931255390656326 0.182762790282107 no 2750 0.175860735755973 4095 3742339 SGTC_247 mechlorethamine 29.705 µM -0.934700776910518 0.181854855824941 no 2751 0.174971263204991 3902 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_881 0833-0569 170 µM -0.937376170388755 0.181151780692405 no 2752 0.174282547090312 4007 5418700 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.937886463220873 0.18101787282714 no 2753 0.174151380268248 4071 5377381 SGTC_2426 5582046 32.21 µM -0.938336420862759 0.180899849216024 no 2754 0.17403577420835 4031 2251934 SGTC_3187 9109394 49.47 µM -0.938644502351733 0.180819067453823 no 2755 0.173956648042421 4027 17098090 SGTC_2241 6772625 37.8075 µM -0.939972557868383 0.180471098137547 no 2756 0.173615818548418 3896 2285411 SGTC_1035 k081-0041 55.2 µM -0.940435044436383 0.180350018798203 no 2757 0.173497226743429 4041 731709 SGTC_583 1488-1091 88.9 µM -0.94219424642641 0.17988992419563 no 2758 0.173046599542722 4133 4303273 SGTC_1820 st053765 18.6 µM -0.943203098001079 0.179626406119276 no 2759 0.172788514545596 4088 3690829 SGTC_3056 9094900 49.47 µM -0.94348855254518 0.179551887733811 no 2760 0.172715533949803 4002 25236784 SGTC_2101 5377231 179.231 µM -0.948178804643313 0.178330273081554 no 2761 0.171519217716511 4073 2844213 SGTC_1397 3532-0190 20.1 µM -0.948230550658405 0.178316824682396 no 2762 0.171506048752662 3967 5322280 SGTC_258 haloperidol 50.781 µM -0.951732735536853 0.177408118845109 no 2763 0.170616271494623 4054 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_107 0358-0022 2.6945 µM -0.95221634179855 0.177282868487177 no 2764 0.17049363743799 4062 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2587 piperic acid 92.2 µM -0.954031645080324 0.176813217057598 no 2765 0.17003381214894 4037 5370536 SGTC_3113 9123498 49.47 µM -0.954277115242682 0.176749769953452 no 2766 0.169971694411353 4122 8897275 SGTC_2266 7929956 200 µM -0.955489906183875 0.176436509012758 no 2767 0.169665003711496 4000 2967153 SGTC_2711 st079103 59.1 µM -0.956560939300907 0.17616015600248 no 2768 0.169394456085373 3998 54693780 SGTC_2908 7930301 100 µM -0.958620421432846 0.175629529136348 no 2769 0.16887500048829 4019 2223178 SGTC_890 0929-0006 47.2 µM -0.960861201773661 0.175053342415515 no 2770 0.168310980501647 4024 1378169 SGTC_2873 9040596 71.43 µM -0.963469952781534 0.174384049579344 no 2771 0.16765586799194 4044 6463863 SGTC_704 1310-0270 142 µM -0.964543338664953 0.174109137803028 no 2772 0.16738679562506 4057 5718033 SGTC_397 arbidol 50 µM -0.964941092052471 0.174007336612954 no 2773 0.167287158993953 4098 131410 A RNA synthesis inhibitor. SGTC_33 0986-0033 35.816 µM -0.966617418537212 0.173578712760539 no 2774 0.16686766184232 3980 2848082 SGTC_384 k007-0144 5.16 µM -0.967590203221625 0.173330287494363 no 2775 0.166624535960593 4014 6824886 SGTC_3238 9133470 49.47 µM -0.969390296639086 0.172871185259078 no 2776 0.166175245934328 4060 3534688 SGTC_3337 9144342 33.5465 µM -0.970863816181972 0.172495950935108 no 2777 0.165808049380511 4053 17682949 SGTC_784 4579-0127 173 µM -0.974527106137274 0.171565340611645 no 2778 0.164897443551543 4114 1948547 SGTC_1123 mangostin 811.285 nM -0.975104520099452 0.171418949452512 no 2779 0.164754208359416 4075 5281650 An antioxidant. SGTC_1742 st038235 28.8875 µM -0.975318436979439 0.171364735602932 no 2780 0.164701163907307 4108 564103 YBR002C RER2 SGTC_566 0958-0068 16.5 µM -0.976861004907683 0.170974120690833 no 2781 0.164318984678851 3962 6815365 SGTC_203 k066-0004 30.888 µM -0.978304758144126 0.170609044477467 no 2782 0.163961808651605 4144 6795412 SGTC_1286 0929-0070 131 µM -0.979459017452829 0.170317530724602 no 2783 0.163676614347882 4155 1420408 SGTC_3182 9108849 49.47 µM -0.9795538092304 0.170293604790281 no 2784 0.163653207520906 4096 17133045 SGTC_2315 7733312 200 µM -0.97973766029007 0.170247205971371 no 2785 0.163607815580943 3976 726316 SGTC_3234 9132280 49.47 µM -0.980209100072363 0.170128264892132 no 2786 0.163491456733064 4096 17612295 SGTC_298 1391-0729 10 µM -0.980903272087601 0.169953226929386 no 2787 0.163320221877364 4007 3237558 SGTC_685 1278-0033 54.9 µM -0.982549658041598 0.169538546602765 no 2788 0.162914565731128 4117 3590572 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.984141706741219 0.169138170301877 no 2789 0.162522921421719 4073 16486 A toxic proline analog. SGTC_75 0159-0059 199.013 µM -0.985402257343598 0.168821591817287 no 2790 0.162213260645832 4181 5377270 SGTC_2927 9011802 47.9 µM -0.985582871303639 0.168776263085979 no 2791 0.162168923377024 4092 43912568 SGTC_2277 7947813 106.88 µM -0.987114462030324 0.168392193771161 no 2792 0.161793264389814 4148 1246798 SGTC_1913 st060213 96.1 µM -0.990105187557393 0.16764384626103 no 2793 0.161061354025268 4127 688959 SGTC_2996 9066192 71.4286 µM -0.992400469935221 0.167070969477436 no 2794 0.16050110491023 4119 6472854 SGTC_1749 st037932 54.2 µM -0.992618012483906 0.167016738858535 no 2795 0.160448071683988 4139 594497 SGTC_1825 st052143 62.6 µM -0.993381719222593 0.166826446271855 no 2796 0.160261983444837 4124 674173 SGTC_3173 9105693 49.47 µM -0.994822735751362 0.166467769710657 no 2797 0.159911243197751 4105 17096658 SGTC_253 dyclonine 31.25 µM -0.995180850057775 0.166378710476404 no 2798 0.159824156912653 4177 3180 An oral anasthetic. SGTC_3001 9076041 71.4286 µM -0.995771903510732 0.166231789048464 no 2799 0.159680492326967 4068 16004211 SGTC_2739 tacrine 100.86 µM -0.99675305762167 0.165988083211912 no 2800 0.159442194433462 4129 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_168 3970-0862 530.542 µM -0.997587076671789 0.165781105436172 no 2801 0.159239815137563 4058 3135186 SGTC_1612 st002233 45.4 µM -0.998252029603445 0.165616204247131 no 2802 0.159078581253298 4077 1035021 SGTC_2886 9058944 51.95 µM -0.998422191439407 0.165574022989687 no 2803 0.159037338602513 3934 4949929 SGTC_2384 9036245 200 µM -1.00059931687518 0.165034950641855 no 2804 0.158510280248561 4023 6462766 SGTC_2246 7293507 91.5585 µM -1.0032080686679 0.164390502740596 no 2805 0.15788024037505 4132 887656 SGTC_1485 3909-9022 254 µM -1.00395470977835 0.164206358394481 no 2806 0.157700222114529 4121 714516 SGTC_1935 st074532 41.6 µM -1.00406990379676 0.164177959971275 no 2807 0.15767246037119 4085 2829742 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.00578540046329 0.16375542087342 no 2808 0.1572594058511 4175 4213774 SGTC_1089 terbinafine 2.25 µM -1.0065714345329 0.163562051084431 no 2809 0.157070383720706 4107 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_105 0111-0055 734.78 µM -1.00813356850632 0.163178195711871 no 2810 0.156695172157928 4106 5179370 SGTC_1075 aripiprazole 15.2 µM -1.0086278850353 0.163056851813831 no 2811 0.156576564425636 4137 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2628 lathosterol 100 µM -1.0088061358877 0.163013109519846 no 2812 0.156533808905863 4175 6710616 SGTC_1570 verbenone 133 µM -1.00918953302923 0.162919050713039 no 2813 0.156441872736319 4119 29025 A natural terpanoid with antifungal properties. SGTC_508 roscovitine 141 µM -1.01004629164915 0.162708989710227 no 2814 0.15623655606512 4169 160355 A CDKinase inhibitor. SGTC_584 0986-0246 15.4 µM -1.0107459727005 0.162537571897403 no 2815 0.156069013760288 4183 53315 YDR232W HEM1 SGTC_3189 9110682 49.47 µM -1.01198722418731 0.162233761704344 no 2816 0.155772081009977 4193 17122418 SGTC_813 k007-0158 173 µM -1.01455200056631 0.161607176008457 no 2817 0.155159714857137 4087 6523916 SGTC_800 3448-7362 155 µM -1.01479556478086 0.161547754371498 no 2818 0.155101644191221 4180 15991913 SGTC_126 0417-1624 672.48 µM -1.01578139743638 0.161307389237012 no 2819 0.154866748220644 4171 41912 YDL195W SEC31 SGTC_718 1130-0073 349 µM -1.01663070410449 0.161100498936395 no 2820 0.154664571042797 4158 6740020 SGTC_3251 9135047 49.47 µM -1.02041063295561 0.160181813016624 no 2821 0.153766876570675 4139 17682963 SGTC_2899 9053889 58.44 µM -1.02387634839736 0.159342509999861 no 2822 0.152946841426207 4101 6470052 SGTC_64 000l-0018 272.079 µM -1.02497936727151 0.159075993681414 no 2823 0.152686461613775 4038 6811119 SGTC_326 k292-0812 17.5 µM -1.02523021524272 0.159015423464679 no 2824 0.152627287237582 4101 3579357 SGTC_2496 diffractaic acid 79.83 µM -1.02540504422323 0.158973217871657 no 2825 0.152586054539358 4148 94870 An apoptosis inducer which activates caspases. SGTC_864 0469-0573 172 µM -1.02744772238544 0.158480637394465 no 2826 0.152104844923787 4103 689425 SGTC_2920 7982904 15.77 µM -1.02980611146754 0.157913171443209 no 2827 0.151550515639713 4132 6456808 SGTC_1862 st057513 3.81 µM -1.03103924940546 0.157616990681553 no 2828 0.151261207198612 4107 5393163 SGTC_1132 3456-3614 2.5 µM -1.03410660764446 0.156881842502151 no 2829 0.150543163787736 4197 3125502 SGTC_97 0535-0701 19.132 µM -1.03521099567325 0.156617709082809 no 2830 0.150285192396295 4031 2832013 YGL099W LSG1 SGTC_1898 st060199 18.6 µM -1.03529743494513 0.156597048002592 no 2831 0.15026501368949 4099 688866 SGTC_1604 st002052 72.4 µM -1.03683599952348 0.156229594012329 no 2832 0.149906147523779 4200 6254834 YHR062C RPP1 SGTC_1574 spiramycin 23.7 µM -1.03948476662327 0.155598323153942 no 2833 0.14928966956832 4096 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM -1.04126800724797 0.155174278977301 no 2834 0.148875590257219 4076 16667744 Haematoxylin. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.04350769740325 0.154642775564348 no 2835 0.148356608839093 4152 4620898 SGTC_1910 st062352 60.4 µM -1.04425481053188 0.154465745206729 no 2836 0.148183757130646 4046 2245730 SGTC_1357 1503-1303 39.5 µM -1.04492916989333 0.154306069120368 no 2837 0.148027853447387 4092 292895 SGTC_1361 1608-0041 5.61 µM -1.04714723367835 0.153781641954785 no 2838 0.147515838687923 4106 X1361 SGTC_3084 9116877 49.47 µM -1.04951424909621 0.153223300245677 no 2839 0.146970750310787 4077 27241325 SGTC_1902 st060212 70.5 µM -1.05069001984176 0.15294645440491 no 2840 0.146700490599184 4145 688944 SGTC_1886 st057356 49.9 µM -1.05375235857637 0.15222695674805 no 2841 0.145998155254783 4105 24207747 SGTC_1711 st032263 62.8 µM -1.05439078677994 0.152077241337626 no 2842 0.145852019319488 4152 3958979 SGTC_599 1935-0052 86.5 µM -1.05466892810399 0.152012046048181 no 2843 0.145788383646989 4127 9557311 SGTC_858 0438-0351 2.77 µM -1.05472099122294 0.15199984471013 no 2844 0.145776474252444 4116 2799119 SGTC_1671 st016596 74.5 µM -1.05578291236302 0.151751118380404 no 2845 0.145533703383037 4203 2829167 SGTC_2061 5245884 80.95 µM -1.05652380800437 0.15157774386959 no 2846 0.145364484796643 4112 573863 SGTC_3353 9151644 39.2805 µM -1.05714270596446 0.151433018604253 no 2847 0.145223231654528 4186 4909158 SGTC_1308 1187-1617 41.4 µM -1.05967548913583 0.15084170143049 no 2848 0.144646128726803 4161 2882570 SGTC_3081 9117243 49.47 µM -1.05999933776258 0.150766204972775 no 2849 0.144572450302865 4130 45595589 SGTC_2999 9069765 71.4286 µM -1.06180805406774 0.150345014883141 no 2850 0.144161416355995 4115 2097066 SGTC_2003 4023581 200 µM -1.06290776292857 0.150089312770998 no 2851 0.143911891118545 4193 16641307 SGTC_1406 3909-7906 11.9 µM -1.0652206984057 0.149552460273481 no 2852 0.143388034552006 4170 X1406 SGTC_2730 imipramine 71.33 µM -1.06632618434678 0.149296320519258 no 2853 0.143138108459918 4128 3696 A tricyclic antidepressant. SGTC_1861 st057647 17.4 µM -1.067765205066 0.148963340200884 no 2854 0.142813218569377 4248 688668 SGTC_3180 9109287 49.47 µM -1.06786346179476 0.148940622323559 no 2855 0.142791053192396 4209 18891271 SGTC_166 k072-0058 166.424 µM -1.06911922295396 0.148650482411009 no 2856 0.142507975392598 4062 5846229 SGTC_2662 daunorubicin 22.37 µM -1.06988599935099 0.148473506899574 no 2857 0.142335312899463 4037 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1051 3253-3903 78 µM -1.07085931899888 0.148249063278078 no 2858 0.142116344986288 4147 5509239 SGTC_2362 9071156 126 µM -1.07303077704339 0.147749152201117 no 2859 0.141628653730089 4188 653133 SGTC_2701 st077767 14.721 µM -1.07531493931381 0.147224514089307 no 2860 0.141116874955666 4136 5721188 SGTC_460 trequinsin 123 µM -1.07536153055141 0.147213825786453 no 2861 0.14110644900665 4229 5537 A vasodilator. SGTC_2565 isoliquiritigenin 100 µM -1.07546840157542 0.147189310912456 no 2862 0.141082535928396 4259 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_72 0744-0168 198.391 µM -1.07788700271969 0.146635245875563 no 2863 0.140542093194666 4056 677577 SGTC_3028 9087778 49.47 µM -1.07796753093196 0.146616822185128 no 2864 0.140524123163116 4154 17217395 SGTC_1192 1488-0095 21.4 µM -1.0785260958356 0.146489073371167 no 2865 0.140399521220628 4230 915875 SGTC_2029 5175081 200 µM -1.08087669455705 0.145952289322826 no 2866 0.139875983384333 4128 1380876 SGTC_3216 9129716 49.47 µM -1.08097314645968 0.145930291777076 no 2867 0.139854529481249 4130 8056934 SGTC_1843 st055809 45.5 µM -1.08212633882729 0.145667458615556 no 2868 0.139598196860583 4232 16413835 SGTC_1232 0279-0259 161 µM -1.08426387341134 0.145181118421267 no 2869 0.139123909178803 4178 1560000 SGTC_1372 2752-0194 270 µM -1.08546159637542 0.144909086021678 no 2870 0.138858631955767 4107 823334 SGTC_2445 5742597 35.57 µM -1.08857270896414 0.144204080001502 no 2871 0.138171178530827 4168 1774255 SGTC_3090 9117696 49.47 µM -1.08952279216671 0.143989244304806 no 2872 0.137961704759561 4143 7923821 SGTC_528 3492-0019 172 µM -1.09005163926327 0.14386975336185 no 2873 0.1378451987648 4177 2869262 SGTC_1531 st059297 52.4 µM -1.09031741841031 0.143809726861942 no 2874 0.137786672477813 4190 7566702 SGTC_2974 9094440 9.66 µM -1.09120388985041 0.143609638534008 no 2875 0.137591588332631 4201 25236134 SGTC_2967 9089538 49.85 µM -1.09173017547093 0.143490937838394 no 2876 0.137475858852767 4200 728216 SGTC_3318 9139014 38.6185 µM -1.09208978250226 0.14340986864089 no 2877 0.137396819993393 4182 16643984 SGTC_210 3551-0445 56.827 µM -1.09217862161853 0.143389845666156 no 2878 0.137377298619532 4231 2865180 YOR207C RET1 SGTC_2576 guaiol 23.12 µM -1.09488249632905 0.142781336706592 no 2879 0.136784059184839 4098 227829 SGTC_2900 5328528 85.29 µM -1.09618139794528 0.142489639555742 no 2880 0.136499699300878 4206 795359 SGTC_695 3505-6186 243 µM -1.09714878204548 0.142272654065874 no 2881 0.13628817921989 4198 1819379 SGTC_582 0987-0078 156 µM -1.09864345311628 0.141937837226726 no 2882 0.135961808149918 4237 1625765 SGTC_731 3966-0296 387 µM -1.09933198757717 0.141783780284699 no 2883 0.135811642377217 4187 660956 SGTC_1220 1838-0075 193 µM -1.09941301197223 0.141765658837357 no 2884 0.135793978851788 4091 5529645 SGTC_3017 9080681 49.47 µM -1.10037844116954 0.141549857228141 no 2885 0.135583633873467 4212 16451914 SGTC_1390 3413-2614 145 µM -1.10439451636859 0.140654536749725 no 2886 0.134711019246354 4218 3421432 SGTC_2728 chlorpromazine 9.18 µM -1.10594377154465 0.14031018431712 no 2887 0.134375428757521 4260 2726 A thorazine and dopamine antagonist. SGTC_730 1436-0052 41.2 µM -1.10615450964887 0.140263387902929 no 2888 0.134329824309011 4231 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3118 9124250 49.47 µM -1.10718686827939 0.140034295951329 no 2889 0.134106571932282 4137 1504786 SGTC_1547 harmine 94.2 µM -1.1108304632019 0.13922777434327 no 2890 0.133320665633204 4152 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2146 5545642 200 µM -1.11266878750341 0.138822057344576 no 2891 0.132925352728446 4167 825326 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.11793445973104 0.137664386284767 no 2892 0.131797493092917 4171 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.11911761434953 0.137405175983065 no 2893 0.131544983108686 4129 5355888 SGTC_1043 0916-0009 19.3 µM -1.11956324746697 0.137307631331567 no 2894 0.131449962293426 4248 3101130 SGTC_885 0865-0106 16.8 µM -1.11965485536768 0.137287585135878 no 2895 0.131430434929246 4148 2793380 SGTC_1432 4049-0298 68.4 µM -1.12195563282492 0.136784770525415 no 2896 0.130940652291918 4237 741646 SGTC_1545 lovastatin 49.4 µM -1.12318843544833 0.136515871008057 no 2897 0.130678736536102 4258 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2252 omeprazole 400 µM -1.12412146864316 0.136312597862538 no 2898 0.13048074940592 4187 4594 A proton pump inhibitor. SGTC_1702 st027038 51 µM -1.12431791083066 0.13626982683814 no 2899 0.130439091353361 4244 5521182 SGTC_2032 5185112 25.99 µM -1.12536154621426 0.136042751867588 no 2900 0.130217929515969 4103 5718189 SGTC_1140 3229-1848 2.98 µM -1.12623910361981 0.135852012849159 no 2901 0.130032162987455 4243 2849525 SGTC_3213 9129884 49.47 µM -1.12668129433427 0.135755971150962 no 2902 0.12993862698186 4213 17190742 SGTC_944 3370-0224 231 µM -1.12724845541777 0.135632854578072 no 2903 0.129818724361411 4238 4580514 SGTC_2519 cryptotanshinone 88.04 µM -1.1282171218406 0.135422758101693 no 2904 0.129614117342209 4199 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2064 5220758 200 µM -1.12840163884341 0.135382763051058 no 2905 0.129575167993395 4282 788518 SGTC_66 0109-0187 42.4 µM -1.13221442219086 0.134558133534129 no 2906 0.128772149092265 4105 759417 SGTC_926 2268-1401 59.4 µM -1.13491264544359 0.133976648762853 no 2907 0.128205960518748 4199 2931578 SGTC_1378 2093-0007 380 nM -1.13583560494849 0.133778141877043 no 2908 0.128012686371096 4284 3618014 SGTC_2921 7974240 10.71 µM -1.1374308958376 0.133435509260137 no 2909 0.127679098837986 4311 2979074 YDR527W RBA50 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.13986310855723 0.132914287203494 no 2910 0.12717166834176 4252 165521 SGTC_1190 1486-1332 13 µM -1.14238764045149 0.132374765595043 no 2911 0.12664646320499 4223 4150046 SGTC_3271 9137798 49.47 µM -1.14291476713382 0.132262303283971 no 2912 0.126536990364422 4178 6498326 SGTC_3244 9134489 49.47 µM -1.14348130674516 0.132141505689303 no 2913 0.126419405820685 4243 16584271 SGTC_1828 st055811 49 µM -1.1443311800457 0.131960438359286 no 2914 0.126243158540601 4235 5877589 SGTC_309 k408-0051 1.48 µM -1.14977128403484 0.130805466350501 no 2915 0.125119042744065 4155 3640463 SGTC_24 0417-1663 219 µM -1.15100282651515 0.13054497414054 no 2916 0.124865536358961 4262 4329390 SGTC_1260 0700-1617 7.75 µM -1.15134709444681 0.130472219808561 no 2917 0.124794734886434 4221 2853078 SGTC_2090 5301565 104.445 µM -1.1535674910024 0.130003655870145 no 2918 0.124338766391993 4247 2056344 SGTC_125 0133-0007 11.75 µM -1.15466634361618 0.129772199517778 no 2919 0.12411354353442 4333 26541 SGTC_351 caspofungin 25 nM -1.15603359984735 0.129484606718316 no 2920 0.123833706902924 4244 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_798 1287-0182 476 µM -1.15652460509028 0.129381435040273 no 2921 0.1237333206179 4295 1649755 SGTC_530 4358-1714 28 µM -1.15940576364678 0.128777184223801 no 2922 0.123145414266202 4243 1564641 SGTC_1092 toremifene 6.32 µM -1.16232257639538 0.128167452949178 no 2923 0.122552229722538 4234 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.16377775929116 0.127864011998922 no 2924 0.122257043764279 4234 16623 A steroid. SGTC_2984 9022109 38.96 µM -1.1656069094843 0.127483298429472 no 2925 0.121886706482696 4284 6459207 SGTC_2669 eugenol 100 µM -1.16810049614129 0.126965561997825 no 2926 0.121383115117375 4259 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2771 fluoxetine 41.05 µM -1.16945365133924 0.126685223556963 no 2927 0.121110452308676 4279 3386 A selective serotonin reuptake inhibitor. SGTC_497 capsazepine 133 µM -1.17170181600427 0.126220416087757 no 2928 0.12065839684146 4220 2733484 A calcium channel blocker. SGTC_2400 5203494 178.7 µM -1.17544149458026 0.125449874125541 no 2929 0.119909065386175 4169 6777674 SGTC_2198 6589944 200 µM -1.17572530557445 0.125391530624872 no 2930 0.119852331492396 4261 5290268 SGTC_2936 9038235 15.59 µM -1.17725610024098 0.12507716920068 no 2931 0.11954665155855 4200 4749415 SGTC_1904 st060225 78 µM -1.18106575350984 0.124297216013741 no 2932 0.118788301638108 4213 66595 SGTC_3122 9126309 49.47 µM -1.18477556595149 0.123540978609609 no 2933 0.118053097902816 4329 17591206 SGTC_904 1141-0088 396 µM -1.18718707379059 0.123051129378552 no 2934 0.11757691919994 4278 1378119 SGTC_1152 3909-8331 15.9 µM -1.18784793527047 0.12291712669233 no 2935 0.11744666253901 4236 16001939 SGTC_1665 st014639 11.4 µM -1.18873008757011 0.122738412429155 no 2936 0.117272948445114 4334 981133 YIL048W NEO1 SGTC_2068 5226020 147 µM -1.19121044048249 0.122236897343059 no 2937 0.116785490952879 4291 1810509 SGTC_1906 st060206 94.7 µM -1.19297843100858 0.121880297712704 no 2938 0.116438910203505 4305 5133468 SGTC_2308 7584454 197.62 µM -1.19302461106365 0.121870993105175 no 2939 0.116429867274301 4328 893577 SGTC_3193 9111931 49.47 µM -1.19488224870882 0.121497119904441 no 2940 0.116066519653955 4290 17087244 SGTC_3155 9099265 49.47 µM -1.19761383520841 0.120948819048368 no 2941 0.115533693733995 4275 25236499 SGTC_1768 st044301 37.178 µM -1.19908506038514 0.120654228155466 no 2942 0.11524743628054 4292 3931349 SGTC_1063 disulfiram 1.84 µM -1.20037945630474 0.120395462721466 no 2943 0.114996001874245 4315 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3307 9126885 69.2785 µM -1.20200635300074 0.120070781091112 no 2944 0.114680533344362 4251 24824909 SGTC_2140 5586273 200 µM -1.20560679887282 0.119354431266291 no 2945 0.113984568224879 4256 854421 SGTC_389 tpck 16.7 µM -1.20648929003216 0.119179310714866 no 2946 0.113814443080474 4326 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2829 7992743 58.44 µM -1.20754839836741 0.11896938200196 no 2947 0.113610508984444 4290 16462845 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.20844327568694 0.11879220959385 no 2948 0.113438401163443 4299 521171 SGTC_1207 2099-0101 141 µM -1.20862621996021 0.118756012304583 no 2949 0.113403239199171 4289 5837381 SGTC_2890 9046729 58.44 µM -1.21087289602742 0.118312121072546 no 2950 0.112972060910582 4257 903329 SGTC_2652 actinonin 100 µM -1.22197261618322 0.116136288226817 no 2951 0.110858991335509 4334 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_42 0133-0086 60.653 µM -1.22478922875076 0.115588705637777 no 2952 0.110327322176172 4177 162923 Model of phenazepam hydroxylation. SGTC_202 3594-0513 34.79 µM -1.2250175481233 0.115544398172386 no 2953 0.110284304430614 4365 708429 SGTC_1197 1601-0112 267 µM -1.22769819941378 0.115025095595894 no 2954 0.109780141312267 4283 7350313 SGTC_1090 efavirenz 20.7 µM -1.22902213634107 0.114769232370771 no 2955 0.109531753259956 4322 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1013 4112-3890 241 µM -1.23985355402373 0.112691159018015 no 2956 0.107514782854369 4260 705171 SGTC_970 1315-0089 19.5 µM -1.24385682867015 0.111929948554863 no 2957 0.106776130312125 4267 6811083 YLR033W RSC58 SGTC_1626 st003712 1.76 µM -1.24589343967185 0.111544107321875 no 2958 0.10640175943966 4355 24207035 SGTC_793 0488-0545 106 µM -1.24711580615414 0.111312984358162 no 2959 0.106177519057244 4347 292548 SGTC_386 1509-0011 3.07 µM -1.25549413379844 0.109738048679161 no 2960 0.104649718148279 4337 3107280 SGTC_504 lovastatin 124 µM -1.25847141236331 0.109182258223617 no 2961 0.104110659829003 4353 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1773 st048542 73.5835 µM -1.26231024321262 0.10846862468878 no 2962 0.103418586136701 4302 3237138 SGTC_3128 9127691 49.47 µM -1.26250390783749 0.108432711822593 no 2963 0.103383760507715 4361 41316314 SGTC_3277 9138724 49.47 µM -1.2633800056984 0.108270356490537 no 2964 0.103226323080656 4297 15943418 SGTC_1124 fisetin 1.16336 µM -1.26459677797222 0.108045158931084 no 2965 0.103007954334302 4343 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_3326 9140064 16.379 µM -1.26508253588307 0.107955350172569 no 2966 0.102920871292421 4283 1868434 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.26611245314366 0.107765113019498 no 2967 0.102736412381654 4377 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1789 tunicamycin 25 nM -1.26774824854067 0.107463460010419 no 2968 0.10244393430165 4226 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3270 9137563 49.47 µM -1.269353424324 0.10716804554549 no 2969 0.102157519970782 4336 17015724 SGTC_2141 5621638 7.665 µM -1.27143620204692 0.10678560733347 no 2970 0.10178675520294 4370 2856238 SGTC_1074 carmofur 3.8 µM -1.27337978586246 0.106429616994074 no 2971 0.101441653422899 4390 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_824 1304-0008 100 µM -1.27405870696168 0.106305466740879 no 2972 0.101321305604278 4375 768245 SGTC_1169 aniline yellow 25.8 µM -1.27426681198114 0.106267432768299 no 2973 0.101284437051753 4263 6051 A DNA damaging agent. SGTC_2194 5927483 104.545 µM -1.28567405286863 0.104197618201892 no 2974 0.0992784201942045 4390 760979 SGTC_3167 9103034 49.47 µM -1.2858847911951 0.104159657159118 no 2975 0.099241636144771 4435 5127859 SGTC_1290 0986-0249 10.2 µM -1.29050886923199 0.103329227609782 no 2976 0.098437017200393 4200 53329 SGTC_3114 9122766 49.47 µM -1.29497324722622 0.102532048851688 no 2977 0.0976647292455669 4368 17176985 SGTC_1943 st076331 65.2 µM -1.29649588651261 0.102261184938943 no 2978 0.0974023481581173 4349 24208415 SGTC_1971 st069429 63.5 µM -1.30172179535587 0.10133550153207 no 2979 0.0965057530622314 4356 1246522 YGL099W LSG1 SGTC_2298 7976326 193.81 µM -1.30777376618909 0.100271141064496 no 2980 0.0954750273496059 4300 2235818 SGTC_1370 2001-0092 44.6 µM -1.31429650148279 0.0991331489669044 no 2981 0.0943732220769589 4385 790957 SGTC_2743 auranofin 4.32 µM -1.31580010715191 0.0988721665688405 no 2982 0.0941205716564311 4402 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_860 0443-0016 25.1 µM -1.3162068767401 0.0988016496217001 no 2983 0.0940523081180335 4399 5337942 SGTC_3324 9138759 60.749 µM -1.31710136802335 0.0986467114584425 no 2984 0.0939023242697295 4406 45595710 SGTC_207 4185-0010 4.486 µM -1.31777279639 0.0985305277567762 no 2985 0.0937898585365279 4461 3761753 SGTC_1049 3226-0134 66 µM -1.31846134523805 0.0984114856117126 no 2986 0.0936746283857711 4406 5702385 SGTC_2138 5575593 77.673 µM -1.32393903425958 0.097468206163469 no 2987 0.0927616465294391 4393 762213 SGTC_1697 st025554 27.742 µM -1.32568015795183 0.0971697712889836 no 2988 0.0924728312497524 4399 1269519 SGTC_2248 tofa 1.1 µM -1.32669144055361 0.0969967419496663 no 2989 0.0923053867722024 4396 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2981 9013952 38.96 µM -1.32837255759598 0.0967096053622982 no 2990 0.0920275302953942 4342 2996344 SGTC_60 0986-0278 202 µM -1.33224384677532 0.0960507600281239 no 2991 0.0913900363096411 4341 3110598 SGTC_3240 9133527 49.47 µM -1.3331312979685 0.0959001929437044 no 2992 0.0912443600243912 4350 17617455 SGTC_1065 prochlorperazine maleate 2.48 µM -1.33342892498595 0.0958497357263325 no 2993 0.0911955427308893 4425 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2910 7948405 25.97 µM -1.33477102744608 0.0956224493492585 no 2994 0.0909756493458346 4343 2971328 SGTC_1726 st035556 14.5795 µM -1.33578475386957 0.0954510368648058 no 2995 0.0908098188219951 4428 5919439 SGTC_3101 9120531 49.47 µM -1.33625777517024 0.0953711304346955 no 2996 0.0907325163847264 4389 24824904 SGTC_2647 atorvastatin 60.16 µM -1.33807856726164 0.0950640076913328 no 2997 0.0904354133143091 4365 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1669 st015249 58.4 µM -1.33878152513709 0.0949456311417487 no 2998 0.0903209034514622 4506 722793 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.34389060077841 0.0940885353658449 no 2999 0.0894918829428368 4389 688669 SGTC_2145 5634607 200 µM -1.34497249061255 0.0939077728031988 no 3000 0.0893170592401374 4376 308662 SGTC_2789 5281112 71.43 µM -1.34763496465394 0.093464017369778 no 3001 0.0888879094996172 4400 765948 SGTC_1238 0333-0287 48.8 µM -1.3511880127178 0.0928742448107174 no 3002 0.088317606761514 4392 7226 SGTC_325 2810-4341 181 µM -1.35126524879579 0.0928614549758619 no 3003 0.0883052398875616 4404 774970 SGTC_3166 9102297 49.47 µM -1.35518728079359 0.0922137007222583 no 3004 0.0876789480210042 4398 25237072 SGTC_137 0438-0332 85.389 µM -1.35987502034213 0.0914438790105394 no 3005 0.0869347385078868 4356 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3060 1327-0027 12.5 µM -1.36061044953422 0.0913235401972296 no 3006 0.0868184137867341 4321 16000455 YPR107C YTH1 SGTC_1573 oleylamine 1.06 µM -1.36177533252537 0.0911331698698307 no 3007 0.0866343993167211 4408 5356789 An amine of the fatty acid oleic acid. SGTC_1871 st057448 67.3 µM -1.36586283312154 0.0904675005359808 no 3008 0.0859910101473668 4419 691747 SGTC_2937 9044753 11.33 µM -1.36592149533607 0.0904579734567759 no 3009 0.0859818025717693 4343 6465530 YGL099W LSG1 SGTC_2826 7992541 19.48 µM -1.36729351179749 0.0902353625410278 no 3010 0.085766662286113 4419 2985066 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.3690424287988 0.0899521894360225 no 3011 0.085493006298093 4461 368090 SGTC_552 k242-0005 476 µM -1.3696138766066 0.0898598076643785 no 3012 0.0854037327850025 4458 4088318 SGTC_1443 4112-3303 14 µM -1.37158711243716 0.0895413512668326 no 3013 0.0850960040146297 4456 704433 SGTC_2803 7707263 71.43 µM -1.37270104293095 0.0893619473893275 no 3014 0.0849226524231789 4386 2199229 SGTC_1150 3909-7983 10.9 µM -1.3734924208029 0.0892346547242636 no 3015 0.0847996579107116 4413 23965914 SGTC_1364 1653-0028 37.6 µM -1.37823218301625 0.0884750893698937 no 3016 0.0840658069088629 4414 5718652 SGTC_488 nitrendipine 139 µM -1.38285624016352 0.0877387184872782 no 3017 0.0833544751833428 4447 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1473 k844-0725 134 µM -1.38291916520531 0.0877287294416947 no 3018 0.0833448265481647 4462 54682906 SGTC_1303 1160-0052 261 µM -1.38481437007071 0.0874282722895982 no 3019 0.0830546178803208 4373 3562476 SGTC_1723 st034307 2.5525 µM -1.39152009372694 0.0863713431887441 no 3020 0.0820338853765119 4425 867466 SGTC_1672 st016598 6.51 µM -1.39370599657773 0.0860288831893825 no 3021 0.0817032023365997 4396 4665860 YNL267W PIK1 SGTC_288 1315-0019 35.1 µM -1.39417495119621 0.085955545768316 no 3022 0.0816323900550026 4470 6811474 SGTC_2664 lyso-paf C-16 73.48 µM -1.39673993317761 0.0855552488599895 no 3023 0.0812458955220995 4386 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_947 3447-0010 211 µM -1.39975063750394 0.085087174343134 no 3024 0.0807940021659127 4392 748350 SGTC_2302 7771753 200 µM -1.40925442105435 0.0836222109917603 no 3025 0.0793799754833425 4416 2203047 SGTC_1992 st073643 23.3 µM -1.41048328223324 0.0834341799396872 no 3026 0.0791985146949975 4437 3161292 SGTC_341 1486-1430 230 µM -1.41160340347638 0.0832630644537855 no 3027 0.0790333848552302 4395 2054753 YPL210C SRP72 SGTC_3131 9127911 49.47 µM -1.41174466812471 0.0832415028883347 no 3028 0.0790125779535013 4444 45595681 SGTC_2813 7971799 71.43 µM -1.41281268342687 0.0830786249524227 no 3029 0.0788554039754405 4443 2234054 SGTC_797 k781-0471 270 µM -1.41561585854595 0.082652266271307 no 3030 0.0784440028072036 4420 23738129 SGTC_323 4013-0906 34.3 µM -1.41692727178982 0.0824533686331197 no 3031 0.0782520960503784 4453 2910086 SGTC_1264 0783-0040 158 µM -1.41810234446217 0.0822754556076761 no 3032 0.0780804434476634 4363 2855798 SGTC_1466 k213-0079 57.5 µM -1.42297734843256 0.0815404377178264 no 3033 0.0773713609021746 4414 3657981 SGTC_1019 4262-0212 3.4 µM -1.42322873843006 0.0815026696369672 no 3034 0.0773349285986141 4456 4677213 SGTC_231 b-estradiol 524 µM -1.43394644347098 0.079904716642636 no 3035 0.075793773426873 4440 450 A steroid. SGTC_1936 st074407 74.3 µM -1.43980521567961 0.0790412796906964 no 3036 0.0749612575820314 4487 809813 SGTC_141 0443-0274 32.331 µM -1.44047875809909 0.0789424709470101 no 3037 0.0748659977727391 4398 1627241 SGTC_836 0330-0104 1.35 µM -1.44322750047577 0.0785402000416626 no 3038 0.0744781975365984 4490 46494820 SGTC_626 0214-0009 33 µM -1.44335687245722 0.0785213051653874 no 3039 0.0744599832341954 4519 3437874 SGTC_178 4092-0806 87.505 µM -1.46006885447549 0.0761093678128741 no 3040 0.0721355756977329 4356 2169044 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.46282710255424 0.0757167678791186 no 3041 0.0717573474917479 4461 803109 SGTC_529 4076-0302 30.3 µM -1.46895491383137 0.0748500783539802 no 3042 0.0709225092743771 4428 5816522 SGTC_516 3992-2719 87.3 µM -1.47340576623108 0.0742253301261959 no 3043 0.0703208281936151 4379 5350887 YDR037W KRS1 SGTC_3040 9091894 49.47 µM -1.47407629688487 0.074131556631657 no 3044 0.0702305248403749 4354 25236966 SGTC_2286 7945697 125 µM -1.47442010422467 0.0740835103955714 no 3045 0.0701842573743741 4465 1245733 SGTC_1947 st076332 61.6 µM -1.4746400632181 0.074052784143763 no 3046 0.0701546689528309 4355 24208416 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.47521086102317 0.0739730943449501 no 3047 0.0700779311875614 4517 1273210 SGTC_367 0335-0881 7.1 µM -1.4786232483479 0.0734980527933584 no 3048 0.0696205178378335 4415 23828853 SGTC_1309 pyrazolanthrone 13.4 µM -1.48310486377947 0.0728777112224657 no 3049 0.0690232759899496 4469 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_546 peri-Naphthalide 147 µM -1.48344906953452 0.0728302327902187 no 3050 0.0689775692487656 4434 223824 A penicillin ester. SGTC_2144 5628481 200 µM -1.48345006319767 0.0728300957623926 no 3051 0.0689774373349991 4482 2818399 SGTC_2665 lovastatin 100 µM -1.48372840699895 0.0727917194532777 no 3052 0.0689404934549314 4515 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1827 berberine 7.24 µM -1.48424966948336 0.0727198926792741 no 3053 0.0688713486124157 4395 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1266 0828-0227 32.9 µM -1.48741816383681 0.0722844606350971 no 3054 0.0684522012557244 4463 3913820 SGTC_10 0279-0212 42.575 µM -1.49122436536571 0.0717640363065789 no 3055 0.06795129935036 4495 39851 YBR002C RER2 SGTC_739 1486-1183 203 µM -1.49123758070307 0.0717622343851154 no 3056 0.0679495651357507 4484 4346692 SGTC_2196 6573537 42.6665 µM -1.493481865457 0.0714567275155292 no 3057 0.0676555488654177 4519 2903087 SGTC_901 1112-0062 60.1 µM -1.49461992703507 0.0713021889473334 no 3058 0.0675068312637173 4478 1908457 SGTC_633 0437-0093 97.7 µM -1.49502809479925 0.0712468259733607 no 3059 0.0674535550297377 4424 2831118 SGTC_1801 st050089 28.441 µM -1.49505564369209 0.0712430904916016 no 3060 0.0674499603722247 4540 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1874 staurosporine 7.6 µM -1.50007711876298 0.0705647137282693 no 3061 0.0667972136097947 4489 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2596 sinensetin 100 µM -1.50050952214233 0.0705065311156517 no 3062 0.0667412344007953 4503 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1299 1079-1439 3.74 µM -1.50450040893302 0.0699712716154377 no 3063 0.0662262840683864 4482 323161 SGTC_2505 galangin 7.89 µM -1.50551410358757 0.0698358136492046 no 3064 0.0660959768202097 4402 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_349 k015-0014 24 µM -1.50641964671424 0.0697149785044947 no 3065 0.0659797401585753 4506 2196908 SGTC_413 propylparaben 100 µM -1.51198108362543 0.0689763901692779 no 3066 0.0652693374294173 4486 7175 A pharmaceutical preservative. SGTC_2028 5153890 36.43 µM -1.51351781500448 0.0687733713611089 no 3067 0.0650740897108481 4483 2830968 YPR165W RHO1 SGTC_489 paxilline 115 µM -1.51812516948623 0.0681674511265999 no 3068 0.0644914235947899 4466 105008 A toxic potassium channel blocker. SGTC_2401 5128683 200 µM -1.51820817059918 0.068156573430528 no 3069 0.0644809642013866 4498 708373 SGTC_1979 st071809 45.3 µM -1.52217900704664 0.0676377398866101 no 3070 0.0639821168709631 4550 4976333 SGTC_3301 9125354 19.7965 µM -1.5246413333243 0.0673175458812295 no 3071 0.0636742909749194 4472 41905162 SGTC_2033 5192550 145 µM -1.52506131421422 0.0672630499073791 no 3072 0.0636219025899009 4513 182073 SGTC_1321 1326-2144 215 µM -1.52582898772733 0.0671635261130823 no 3073 0.0635262297384143 4478 3513030 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.52846435013099 0.0668227350421393 no 3074 0.0631986441484921 4507 75037 A free radical scavenger. SGTC_35 0133-0054 64.071 µM -1.53348574820217 0.0661770995072081 no 3075 0.062578107756591 4478 99677 SGTC_971 1315-0384 26.7 µM -1.53412365173029 0.066095426967343 no 3076 0.0624996178433354 4537 6769120 SGTC_1956 st077085 54 µM -1.53801057627353 0.065599459779839 no 3077 0.0620230144181628 4537 24208685 SGTC_55 0767-0285 6.563 µM -1.54145102473766 0.0651628743034635 no 3078 0.0616035268950479 4437 3116166 SGTC_2782 7736369 71.43 µM -1.54162472136321 0.0651408925104386 no 3079 0.0615824072805093 4500 2950836 YOL077C BRX1 SGTC_302 1094-0063 18.9 µM -1.54762076198171 0.064385599088142 no 3080 0.0608568148481477 4512 5440289 SGTC_2988 9073640 71.4286 µM -1.55036323527489 0.0640424184308408 no 3081 0.0605271787696844 4531 9102229 SGTC_1738 st035555 74 µM -1.55276151305459 0.0637434759991948 no 3082 0.0602400602558937 4525 5331140 SGTC_262 fenpropimorph 62.5 µM -1.55579627457316 0.0633667538606412 no 3083 0.0598782721514722 4547 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_579 4491-1009 110 µM -1.56286681760815 0.0624957710889129 no 3084 0.059041961967581 4594 1271041 SGTC_3075 9116269 49.47 µM -1.5645123443354 0.0622944124511891 no 3085 0.058848648145811 4536 17015205 YNL244C SUI1 SGTC_956 1185-0240 191 µM -1.56801027304468 0.0618680616810653 no 3086 0.0584393674415834 4500 1416193 SGTC_878 0828-0289 13.7 µM -1.56837736601627 0.0618234503244105 no 3087 0.0583965450689219 4490 745350 YLR208W SEC13 SGTC_1155 4088-0394 48.2 µM -1.57155829491927 0.0614379353755089 no 3088 0.0580265124611104 4529 2326248 SGTC_895 0964-0006 13.7 µM -1.57171766488612 0.061418669926782 no 3089 0.0580080217808889 4532 6738897 SGTC_1916 st067606 49.2 µM -1.57175255409071 0.0614144529727188 no 3090 0.0580039744270409 4423 19590279 SGTC_1597 7-benzyloxygramine 47.5 µM -1.57357875248674 0.0611940413970138 no 3091 0.0577924342910251 4430 260807 SGTC_1250 0485-0349 40.2 µM -1.57586035072699 0.0609195348590729 no 3092 0.0575289951404804 4529 6842794 YDL195W SEC31 SGTC_328 k915-0120 63.5 µM -1.5766542408275 0.0608242454431669 no 3093 0.0574375523977645 4551 6624543 SGTC_1120 ficusin 1.78878 µM -1.57879203102767 0.0605682292090819 no 3094 0.0571918835304569 4535 6199 A DNA cross-linker. SGTC_2887 9044784 58.44 µM -1.58220291984199 0.0601614964785909 no 3095 0.0568016270193557 4460 6465546 SGTC_2835 9006588 71.43 µM -1.58300186825544 0.0600665353615023 no 3096 0.0567105192834056 4497 2345538 SGTC_3111 9122088 49.47 µM -1.58324246748063 0.0600379613129781 no 3097 0.0566831052197335 4473 16876704 SGTC_2378 9074213 121.43 µM -1.58516621206989 0.0598098761650239 no 3098 0.0564642875385541 4520 657714 SGTC_2878 9043973 25.97 µM -1.59089156135221 0.0591350758903454 no 3099 0.0558169910055827 4556 6465167 SGTC_2204 7233102 200 µM -1.59364703968268 0.0588124457432985 no 3100 0.0555075561710977 4538 2172480 SGTC_905 2-aminofluorene 215 µM -1.59496030066199 0.0586591670690835 no 3101 0.0553605568304418 4554 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2348 9022543 33.42 µM -1.59519890058271 0.0586313523142578 no 3102 0.0553338822736557 4553 3162678 YDL140C RPO21 SGTC_668 1682-0499 62.6 µM -1.59612669002694 0.0585232937753901 no 3103 0.0552302554243803 4526 682214 SGTC_1460 k062-0059 9.15 µM -1.60220863285932 0.0578188047889626 no 3104 0.0545547408512235 4433 1373085 SGTC_1246 0422-0085 105 µM -1.60602723318026 0.0573799036185303 no 3105 0.0541339632304532 4533 264295 SGTC_3076 9116187 49.47 µM -1.61071038236714 0.0568452167769637 no 3106 0.0536214308595346 4553 27241210 SGTC_9 0092-0002 10.449 µM -1.61134287615904 0.0567733051249784 no 3107 0.0535525052018658 4546 759368 SGTC_1772 st048439 82.2 µM -1.61189969974481 0.056710056154535 no 3108 0.0534918837775494 4580 2927068 YDL195W SEC31 SGTC_1237 0330-0133 46.1 µM -1.61317701901159 0.0565651765919848 no 3109 0.0533530273598206 4496 X1237 YHR072W ERG7 SGTC_679 0422-0091 41.4 µM -1.61395428597672 0.0564771581452743 no 3110 0.0532686711584723 4577 627384 YHR062C RPP1 SGTC_2796 7949634 45.45 µM -1.61400380115007 0.0564715546592184 no 3111 0.0532633008978241 4518 2971588 SGTC_2452 5863136 48.41 µM -1.61400452672046 0.0564714725518148 no 3112 0.0532632222079213 4512 2184096 SGTC_96 0929-0093 37.281 µM -1.61442079003492 0.0564243826374208 no 3113 0.053218092612339 4554 6991579 SGTC_796 1234-0020 70.7 µM -1.61635539698973 0.0562059356639963 no 3114 0.0530087479842555 4501 46495034 SGTC_3171 9103192 49.47 µM -1.61748931279276 0.0560782093627274 no 3115 0.0528863503751818 4617 13018434 SGTC_803 4488-1585 147 µM -1.61769201320564 0.0560554009621025 no 3116 0.0528644940407822 4552 747204 SGTC_205 1486-1330 71.903 µM -1.62732783315539 0.0549795682212469 no 3117 0.0518337447994505 4639 4118834 SGTC_327 1273-0057 3.96 µM -1.62891203978659 0.0548042647799081 no 3118 0.0516658204816683 4476 3108138 SGTC_2167 5876490 200 µM -1.63166625921123 0.0545005434234041 no 3119 0.0513749058138858 4564 686534 SGTC_2658 polymyxin b sulfate 77.05 µM -1.63246480483443 0.0544127332461209 no 3120 0.0512908034509993 4592 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_363 0455-0021 3.06 µM -1.63402110306532 0.0542419202162338 no 3121 0.051127209783986 4504 4597466 SGTC_1415 3966-0071 78.1 µM -1.63836605210959 0.053767281345009 no 3122 0.0506726782083472 4478 2893185 SGTC_2581 avocatin a 64 µM -1.639364303297 0.0536586991697454 no 3123 0.0505687056567989 4494 6710728 A skin care supplement. SGTC_691 1548-0686 185 µM -1.64801589249323 0.052724905690704 no 3124 0.0496747049996908 4536 46495133 SGTC_1164 k060-0068 93.7 µM -1.64834180387923 0.052689982659013 no 3125 0.0496412754497061 4569 5963676 SGTC_324 1315-0088 19.6 µM -1.65267046663387 0.052227883600384 no 3126 0.049198974070875 4540 6787421 SGTC_3087 9117406 49.47 µM -1.65529892506789 0.0519488612490329 no 3127 0.0489319384433443 4561 42546093 SGTC_1020 4335-0961 93.3 µM -1.66610607018 0.0508140614479234 no 3128 0.0478461448646205 4536 669075 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.66628391777414 0.0507955530558684 no 3129 0.0478284391834007 4633 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3248 9135562 49.47 µM -1.6763158485347 0.0497602043554703 no 3130 0.0468381711001334 4572 17650701 SGTC_3151 9099821 49.47 µM -1.67654659142761 0.0497365900240298 no 3131 0.0468155890640624 4518 17174189 SGTC_2965 9082772 38.63 µM -1.67720059299579 0.0496697077893101 no 3132 0.0467516315687972 4553 16459634 SGTC_2129 girgensonine 121.053 µM -1.67877577912982 0.0495089140952674 no 3133 0.0465978753731397 4559 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3252 9135871 49.47 µM -1.68073148031673 0.0493098561661269 no 3134 0.0464075415108095 4594 17682838 SGTC_1629 st005085 44.9 µM -1.68409152662713 0.0489693517675105 no 3135 0.0460819908367836 4552 24207091 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.68696912539915 0.0486792338804495 no 3136 0.0458046444197963 4541 6857784 SGTC_1302 1159-0335 255 µM -1.68773711944576 0.0486020378801744 no 3137 0.0457308514686873 4616 649284 SGTC_976 1348-1067 47.6 µM -1.68819234012672 0.0485563269531474 no 3138 0.0456871565712102 4594 5310671 YGL099W LSG1 SGTC_1523 st012844 44.7 µM -1.69369225331487 0.0480067660506229 no 3139 0.0451618886429826 4617 4274103 SGTC_1331 1472-0049 76.2 µM -1.69402106220746 0.0479740692471528 no 3140 0.0451306404048418 4570 24051409 SGTC_3317 9138495 8.753 µM -1.69425082730634 0.047951231954246 no 3141 0.0451088150873438 4508 17020139 SGTC_1319 1306-0155 43.7 µM -1.69712744473759 0.047666049037051 no 3142 0.0448362842778137 4624 3122360 SGTC_1984 st072354 53.1 µM -1.70425384110688 0.0469653992968941 no 3143 0.0441668372049812 4492 5762938 SGTC_1818 st052136 56.3 µM -1.7054220276515 0.0468513379482884 no 3144 0.0440578714947782 4246 674169 SGTC_2059 5238311 157 µM -1.7091367130851 0.0464901132684603 no 3145 0.0437128142181821 4553 703021 SGTC_1719 st032227 49.2 µM -1.70939055467341 0.0464655109427339 no 3146 0.0436893146794793 4575 3125804 SGTC_2570 licareol 100 µM -1.71597961798613 0.0458305472721515 no 3147 0.0430828864769739 4557 443158 SGTC_1171 0368-0077 21.4 µM -1.72147199455737 0.0453066124898606 no 3148 0.0425826049189192 4572 3239779 SGTC_1398 3558-0053 112 µM -1.7244544307736 0.0450241335940361 no 3149 0.0423129193156889 4590 4532369 SGTC_3170 9103054 49.47 µM -1.72643477727829 0.0448373511181833 no 3150 0.0421346118563576 4564 16432970 SGTC_2086 5274770 176.623 µM -1.7274279698417 0.0447439102846167 no 3151 0.0420454155054291 4629 689278 SGTC_949 1165-0505 146 µM -1.73003183539399 0.0444996795982066 no 3152 0.0418122937526442 4578 6244267 SGTC_3346 9158254 43.5805 µM -1.73541603701649 0.0439980727199281 no 3153 0.0413335707799778 4623 17639500 SGTC_44 0929-0055 61.211 µM -1.73574648351984 0.0439674365363672 no 3154 0.0413043352397326 4456 1379590 SGTC_673 1082-0474 110 µM -1.73602070594468 0.0439420260342044 no 3155 0.0412800867316669 4580 3098046 SGTC_1609 st001574 46.4 µM -1.7395851031458 0.0436128116351335 no 3156 0.0409659484428856 4591 3960012 SGTC_2543 pimpinellin 60.67 µM -1.74278494287527 0.0433189666426691 no 3157 0.0406855937128302 4477 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1401 3807-4679 7.6 µM -1.74678030347218 0.0429543144595021 no 3158 0.0403377272280972 4534 3291456 SGTC_3332 9141069 11.198 µM -1.74706820354126 0.0429281342273237 no 3159 0.040312754040888 4556 17332883 SGTC_918 glabranin 770.725 nM -1.74718523293971 0.0429174958295406 no 3160 0.040302606202103 4604 124049 Also referred to as licorice root. SGTC_2340 7987427 183.45 µM -1.74879373661614 0.04277149275453 no 3161 0.0401633399336297 4596 2239331 SGTC_825 1988-2224 89.6 µM -1.75359657509089 0.042337929290084 no 3162 0.0397498291523965 4604 1180859 SGTC_347 4534-1311 26.2 µM -1.75747272118338 0.0419906190194241 no 3163 0.0394186337689434 4620 2862016 SGTC_1761 st044296 37 µM -1.76015025476972 0.0417520563485451 no 3164 0.0391911669190147 4631 1826700 SGTC_2539 epi(13)torulosol 80 µM -1.76445747740184 0.041370595985394 no 3165 0.038827494246841 4578 6708597 SGTC_1681 tripelennamine 100 µM -1.77301626357365 0.0406209882920336 no 3166 0.0381130059902702 4542 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1944 st076371 56.9 µM -1.77664609036432 0.0403064226349504 no 3167 0.0378132436373482 4583 24208455 SGTC_690 glyoxal 20.3 µM -1.78230498045543 0.0398199645737134 no 3168 0.0373497554856463 4422 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_957 1187-1561 14.1 µM -1.78429214336318 0.0396502775183324 no 3169 0.0371881031147312 4566 1538454 SGTC_2476 5806916 10.51 µM -1.80187767312317 0.0381741105475067 no 3170 0.0357823268435233 4568 2870194 SGTC_1835 st008666 49.2 µM -1.80308555177524 0.0380743858967923 no 3171 0.0356873899357972 4598 690455 SGTC_106 0092-0003 11.579 µM -1.80638767377203 0.0378028409039594 no 3172 0.0354289027964479 4572 1072148 SGTC_1857 st056007 79.3 µM -1.81683626820392 0.0369540133532976 no 3173 0.0346210938125745 4626 619834 SGTC_1195 1502-0147 41.1 µM -1.81804991934258 0.0368564362452639 no 3174 0.0345282516872275 4644 817940 SGTC_2726 cimetidine 79.27 µM -1.8222038426033 0.0365240557089077 no 3175 0.034212030879276 4660 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_175 3793-3120 23.7 µM -1.82958073886384 0.0359398327231984 no 3176 0.0336563280352066 4609 5322297 SGTC_2688 kanamycin b 96.69 µM -1.83910527146728 0.035196870128461 no 3177 0.032949851913608 4577 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_614 0462-0418 107 µM -1.8392094796093 0.035188811575831 no 3178 0.0329421904594277 4429 5188303 SGTC_913 3487-1245 167 µM -1.84085640665241 0.0350616534224128 no 3179 0.0328213020900223 4572 4016153 SGTC_2661 dactinomycin 12.96 µM -1.84304208403293 0.0348934812268075 no 3180 0.0326614331259218 4643 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1154 4088-0362 150 µM -1.84413828276336 0.0348093862551942 no 3181 0.0325814949944246 4655 6618304 SGTC_2525 harmine 47.85 µM -1.84417627862627 0.0348064743860183 no 3182 0.0325787271171155 4662 5280953 A monoamine oxidase inhibitor SGTC_1824 st053723 68.6 µM -1.84691040736152 0.0345974647754843 no 3183 0.0323800630677973 4647 675225 SGTC_745 0469-0705 296 µM -1.86424201897823 0.0332964135015055 no 3184 0.0311438625235568 4676 3486736 SGTC_2666 tannic acid 100 µM -1.8646092978351 0.0332692846751496 no 3185 0.0311180943190009 4622 16134267 A thiamine antagonist. SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.87870334766888 0.0322419109700378 no 3186 0.0301425052338512 4669 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_269 exalamide 29 µM -1.87932654798401 0.0321970946790521 no 3187 0.0300999594432897 4651 3316 A derivative of salicylamide. SGTC_2815 7968870 71.43 µM -1.88301263382234 0.0319330670585323 no 3188 0.0298493279227476 4576 2977326 YHR190W ERG9 SGTC_1668 st014914 51.6 µM -1.89010361564001 0.0314301812952876 no 3189 0.0293720518279773 4674 2839556 SGTC_3338 9144300 39.5675 µM -1.89451292718996 0.0311207915194164 no 3190 0.0290784800683435 4654 4901274 SGTC_1662 st014054 52 µM -1.8953599861406 0.0310616450741958 no 3191 0.0290223630149483 4709 2838777 SGTC_1457 k015-0032 57.3 µM -1.89642696334088 0.0309872750871974 no 3192 0.0289518046358768 4651 4302660 SGTC_2390 9097792 176.6 µM -1.89781015639757 0.0308910837443053 no 3193 0.0288605474103216 4676 4497149 SGTC_1021 4476-0760 85.3 µM -1.90185748451065 0.0306110392601539 no 3194 0.0285948943448528 4677 746768 SGTC_1218 1348-1416 30.7 µM -1.90918287005022 0.030109525100709 no 3195 0.0281192526436235 4646 6787668 SGTC_2238 6671620 73.2395 µM -1.90965803432474 0.0300772308159982 no 3196 0.0280886288019447 4577 729941 SGTC_729 4092-0585 94.1 µM -1.91441635192291 0.0297554153282239 no 3197 0.027783488921038 4675 2169061 SGTC_1694 st024011 44.9 µM -1.91495099835799 0.0297194352114934 no 3198 0.0277493765409771 4695 2787533 SGTC_769 0302-0231 76 µM -1.91535440753115 0.0296923108743637 no 3199 0.0277236606812401 4595 571869 YER009W NTF2 SGTC_1488 4013-0813 75.9 µM -1.92031824550565 0.0293602317352122 no 3200 0.0274088565517451 4695 2910057 SGTC_2203 7227154 166.4 µM -1.92915128831732 0.028776932021283 no 3201 0.0268560417039779 4680 896304 SGTC_2840 9008771 71.43 µM -1.93145211521984 0.0286265861323937 no 3202 0.0267135827952513 4634 2992978 SGTC_2192 5915882 198.485 µM -1.93429916142837 0.0284414528295899 no 3203 0.0265381781449773 4678 2876149 SGTC_233 rapamycin 362 pM -1.93968921505327 0.0280936848209422 no 3204 0.0262087355341578 4682 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1746 st038117 42 µM -1.94269828098388 0.0279010838288068 no 3205 0.0260263120327058 4674 2898218 SGTC_1001 4048-4355 44.4 µM -1.94345975579002 0.02785251895435 no 3206 0.025980316669788 4662 21824233 SGTC_2473 5854593 8.94 µM -1.95035234529962 0.0274161231262266 no 3207 0.0255670688194091 4659 2872951 SGTC_818 4072-2707 53.5 µM -1.95278464143243 0.0272634926971929 no 3208 0.0254225595913107 4611 882871 SGTC_672 1441-0018 53.7 µM -1.96059591742851 0.0267781085154527 no 3209 0.0249630895034353 4688 251141 SGTC_3233 9132340 49.47 µM -1.96664489295733 0.026407208220921 no 3210 0.0246120820439032 4687 17682950 SGTC_2235 salicylic acid 500 µM -1.96800952690439 0.026324130248571 no 3211 0.0245334707784886 4729 338 A COX inhibitor and kinase inhibitor. SGTC_2052 5265182 7.135 µM -1.97408520968316 0.0259568940458802 no 3212 0.0241860274064315 4647 1239884 SGTC_855 0428-0020 25 µM -1.97625287449294 0.0258269141930819 no 3213 0.0240630720412293 4690 6812414 SGTC_2320 7373003 200 µM -1.98531360180771 0.0252894871446208 no 3214 0.0235547958302253 4636 5415828 SGTC_1683 st010134 710 nM -1.99950193326682 0.0244667630619228 no 3215 0.0227770364493919 4658 3818134 SGTC_20 0481-0013 4.944 µM -2.00105621770743 0.02437801735559 no 3216 0.0226931659336013 4724 182045 SGTC_1674 st016616 23.6 µM -2.00254167588844 0.0242934541785851 no 3217 0.022613252755258 4665 625830 SGTC_399 oxolinic acid 75 µM -2.00626783919431 0.02408241694403 no 3218 0.0224138396905577 4671 4628 A DNA gyrase inhibitor. SGTC_1025 k007-0731 70 µM -2.01900333178186 0.0233727152026842 no 3219 0.0217434366063134 4667 6256118 SGTC_1145 3546-0597 10.2 µM -2.02071552872086 0.023278656626517 no 3220 0.0216546106979262 4684 875334 SGTC_765 1319-0117 244 µM -2.02359048670669 0.0231214390786753 no 3221 0.0215061523435722 4661 3487746 YGL099W LSG1 SGTC_1530 rhein 70.4 µM -2.0260758371466 0.0229862487089056 no 3222 0.0213785068872166 4741 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2195 6536160 144.242 µM -2.02988601953268 0.0227802873046975 no 3223 0.0211840632449401 4709 3834386 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -2.04012974046937 0.0222342545951347 no 3224 0.0206687026342848 4719 91467 include heat shock SGTC_1317 1273-0028 910 nM -2.04172717309948 0.0221501082507686 no 3225 0.0205893008902026 4707 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2466 5983409 37.09 µM -2.04556138415614 0.0219492335052247 no 3226 0.0203997720100946 4693 2879657 SGTC_696 1560-0013 611 µM -2.04945190778099 0.0217469828887032 no 3227 0.0202089729595304 4695 1650269 SGTC_3202 9113761 49.47 µM -2.05612112306023 0.0214039432516285 no 3228 0.0198854213400614 4625 4798415 SGTC_2089 5281248 129.67 µM -2.05653784986994 0.0213826610891579 no 3229 0.0198653509241379 4695 2737878 SGTC_652 0437-0092 114 µM -2.06416290287818 0.0209963986001483 no 3230 0.0195011367647086 4679 3091274 SGTC_3197 9113331 49.47 µM -2.06842147613083 0.020783253427761 no 3231 0.019300203728942 4672 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_594 1487-1584 10.8 µM -2.07329401595297 0.0205416288119217 no 3232 0.0190724626370462 4696 5013332 SGTC_1478 0453-0656 35.7 µM -2.08124631368921 0.0201523945888064 no 3233 0.0187056831839171 4740 5258496 SGTC_1242 0402-0103 60.1 µM -2.08884977612865 0.019786101471152 no 3234 0.0183606240302942 4646 432868 SGTC_1791 st048313 56.1 µM -2.09107987296963 0.0196797454057222 no 3235 0.0182604523045387 4724 1204976 SGTC_1244 0416-0015 52.5 µM -2.09599568392613 0.0194470174810415 no 3236 0.0180412869094943 4686 96201 SGTC_1194 1488-0194 225 µM -2.09609400035149 0.0194423868634171 no 3237 0.0180369265670987 4714 1391452 SGTC_2341 7987486 176.74 µM -2.09632674521828 0.0194314285170599 no 3238 0.0180266078919756 4707 1258686 SGTC_1695 st026914 34.495 µM -2.10505015017577 0.0190244710887667 no 3239 0.0176434714280331 4719 3289191 SGTC_1775 st081588 35.1725 µM -2.11758641485934 0.0184523458948074 no 3240 0.0171050548545084 4687 1426443 YGL099W LSG1 SGTC_2053 5265679 138 µM -2.12216134952215 0.0182472382224028 no 3241 0.0169120954993304 4632 764595 SGTC_1839 st053978 48 µM -2.12519769672856 0.0181121850997437 no 3242 0.0167850600784991 4720 3788398 SGTC_1091 telmisartan 47.6 µM -2.13486088636163 0.0176880345037253 no 3243 0.0163861875456544 4728 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2663 amphotericin b 100 µM -2.13539037584653 0.0176650403916293 no 3244 0.016364568080264 4725 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.14179342033845 0.0173889891254446 no 3245 0.016105054566792 4671 279621 SGTC_727 3032-0951 202 µM -2.14284505743274 0.0173440044723369 no 3246 0.0160627709738149 4742 3652836 SGTC_21 0849-0113 22.993 µM -2.14616353772338 0.0172027048322908 no 3247 0.0159299667569149 4726 1560156 SGTC_653 0203-0016 55.2 µM -2.1565610228078 0.0167663355012444 no 3248 0.0155199421326214 4748 295302 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.15667581081075 0.0167615713316689 no 3249 0.0155154665034204 4742 688664 SGTC_1952 st077036 64.1 µM -2.16074561382814 0.016593404709134 no 3250 0.0153574976471215 4722 2937007 SGTC_1611 st001856 99.4 µM -2.16355693223506 0.0164780844081872 no 3251 0.0152491849432742 4723 647478 SGTC_3356 9151811 4.48 µM -2.16759639856678 0.0163135870092148 no 3252 0.01509470400766 4739 1859254 YPR165W RHO1 SGTC_3148 9097893 49.47 µM -2.17353482554899 0.0160743136000329 no 3253 0.0148700438294423 4684 17174100 SGTC_3117 9124945 49.47 µM -2.18225223467118 0.0157285195084433 no 3254 0.0145454610640762 4665 17592065 SGTC_3199 9111318 49.47 µM -2.1949384988366 0.0152367024313642 no 3255 0.0140840048522852 4647 8548020 SGTC_3351 9150312 21.596 µM -2.21071777360487 0.014643459733691 no 3256 0.0135276934751346 4676 4904905 SGTC_348 k064-0012 10.7 µM -2.220711371018 0.0142781069023989 no 3257 0.0131852583890059 4709 5066323 SGTC_1403 3909-7815 62.9 µM -2.24087572481234 0.0135647710414382 no 3258 0.0125170630421245 4747 6615483 SGTC_1515 3460-0031 42.1 µM -2.24339101613551 0.0134779849241192 no 3259 0.0124358053561786 4719 2876596 SGTC_1722 st034304 3.6505 µM -2.24701241886865 0.0133538762903174 no 3260 0.0123196167223684 4672 4036148 YLR033W RSC58 SGTC_1481 3346-2004 36 µM -2.25460249680514 0.0130969563613187 no 3261 0.0120791452992816 4774 2770522 SGTC_2084 5306078 60.6385 µM -2.25522555657083 0.0130760571541628 no 3262 0.0120595872809876 4709 679340 SGTC_925 2064-1272 59.6 µM -2.26477973672302 0.0127591744687799 no 3263 0.011763099751574 4718 6815817 SGTC_1300 1094-0077 113 µM -2.2726283976404 0.0125038506851187 no 3264 0.0115242914245409 4741 5532636 SGTC_2112 5488546 200 µM -2.27489308670733 0.012431005730698 no 3265 0.0114561720855057 4714 600757 SGTC_1474 0330-0125 5.35 µM -2.2798517168956 0.0122727909744551 no 3266 0.0113082422558485 4773 X1474 SGTC_2972 9093619 59.92 µM -2.29585936045229 0.011773885354607 no 3267 0.0108419620278107 4705 25236256 SGTC_550 4123-0385 25.7 µM -2.30181077833979 0.0115929390974162 no 3268 0.0106729227294602 4747 5731123 SGTC_2874 9043904 71.43 µM -2.31379089406168 0.0112360074943556 no 3269 0.0103395975535969 4696 4463428 SGTC_2202 7226349 200 µM -2.31441084223979 0.0112177997985098 no 3270 0.010322598358199 4766 844334 SGTC_232 clozapine 119 µM -2.31707763030782 0.0111397691943507 no 3271 0.010249751665553 4779 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3065 9113888 49.47 µM -2.32890597270651 0.0107993327673897 no 3272 0.00993202372977665 4738 16648368 SGTC_520 3584-0023 682 µM -2.34067366420519 0.0104696653924165 no 3273 0.00962449194459247 4713 1340790 SGTC_1493 4348-0038 111 µM -2.34518827053462 0.0103455378917758 no 3274 0.00950873695592271 4763 800424 SGTC_36 0335-0881 14.2 µM -2.34914866779414 0.0102377065930432 no 3275 0.00940819610521153 4696 23828853 SGTC_3179 9107801 49.47 µM -2.37238601639623 0.0096245522877056 no 3276 0.00883680767055197 4750 4818259 SGTC_2881 9058953 51.95 µM -2.38091981311182 0.00940756953388069 no 3277 0.00863473534585173 4722 17122249 SGTC_74 000s-0487 160.283 µM -2.38941971781655 0.00919571387206596 no 3278 0.0084375057702744 4680 677548 SGTC_2283 7944793 200 µM -2.40480866399341 0.00882276008260819 no 3279 0.00809046758212067 4728 2970533 SGTC_2161 5662504 8.5105 µM -2.41182766971581 0.00865710194646 no 3280 0.00793639096759369 4761 2859334 SGTC_1709 st033179 39.1045 µM -2.41899711274369 0.00849071576677408 no 3281 0.00778168187058799 4758 573381 SGTC_1245 0418-0076 17.2 µM -2.42183069416393 0.00842573267873548 no 3282 0.00772127166422332 4739 6790114 SGTC_1082 camptothecin 424.86 nM -2.46056831865849 0.00758015806631216 no 3283 0.00693585794213226 4667 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2128 5255449 168.493 µM -2.47035835450246 0.00737866417049238 no 3284 0.00674888808489933 4704 736008 SGTC_2737 bleomycin 30.5 nM -2.47608981971112 0.00726290550797258 no 3285 0.0066415078359707 4793 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3283 9109332 35.8195 µM -2.48566918835435 0.00707300267065738 no 3286 0.00646540527038327 4666 17027281 SGTC_1610 st001799 48.1 µM -2.49735841662674 0.00684721889502389 no 3287 0.00625612096570438 4733 621897 SGTC_2755 lomerizine 42.69 µM -2.50797381207253 0.00664771711971221 no 3288 0.00607128329831199 4730 3949 A calcium channel blocker. SGTC_2995 9067767 71.4286 µM -2.51300486274174 0.00655497316490599 no 3289 0.00598538424360825 4745 11673567 SGTC_619 1652-1634 108 µM -2.53289871336014 0.00619935542298672 no 3290 0.00565618175627882 4750 5400454 SGTC_1185 1319-0113 81.3 µM -2.536531908746 0.00613628721472009 no 3291 0.0055978269685054 4775 4672763 SGTC_954 1189-0853 2.85 µM -2.54238567120309 0.0060358677263433 no 3292 0.00550493068292381 4727 2828194 SGTC_3047 9092122 49.47 µM -2.54985384008515 0.00590986968514004 no 3293 0.00538840445017369 4743 17173831 SGTC_2263 7948595 193.29 µM -2.56329147289303 0.00568902256344964 no 3294 0.00518424818380117 4775 2971371 SGTC_1328 1441-0025 69.2 µM -2.57109469874029 0.00556416695666196 no 3295 0.00506888007322669 4782 4562601 SGTC_246 cycloheximide 667 µM -2.57815798154972 0.00545325582896458 no 3296 0.00496642873044599 4762 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1459 k035-0031 35.7 µM -2.57994343668226 0.00542553271081911 no 3297 0.00494082496123906 4666 3877128 YMR208W ERG12 SGTC_2614 arthonioic acid 13.39 µM -2.58674016699437 0.00532114117636449 no 3298 0.00484443116029542 4695 6710684 SGTC_2464 5717415 7.67 µM -2.58900619041088 0.00528673631334037 no 3299 0.00481266820551924 4752 5285744 SGTC_1806 st050005 60.3 µM -2.61467181234397 0.0049106483162569 no 3300 0.00446566138849391 4780 5194765 SGTC_2760 etidronate 98.04 µM -2.62797230483746 0.00472528812571871 no 3301 0.00429477543095542 4746 3305 A chelator and antioxidant. SGTC_16 erodoxin 22.806 µM -2.62950688178973 0.00470430841741205 no 3302 0.00427544005937473 4792 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1987 st072290 61.9 µM -2.6355540510548 0.0046224421224427 no 3303 0.00420000231595431 4776 54697379 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.64233344829811 0.00453217661166385 no 3304 0.00411684748479047 4710 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1471 k673-0312 37 µM -2.65009726519387 0.00443073966836695 no 3305 0.00402343004538558 4789 24099884 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.68603732375755 0.00398711275445685 no 3306 0.00361525056844645 4763 229346 A bile salt which induces apoptosis. SGTC_1614 st002383 48.6 µM -2.6922558210631 0.00391452559065831 no 3307 0.0035485241849725 4792 1947235 SGTC_2189 6047310 154.431 µM -2.70011589616641 0.00382447168248207 no 3308 0.00346576624559204 4784 711535 SGTC_1202 1988-0068 29.6 µM -2.70345960481128 0.0037867286627161 no 3309 0.00343108941631219 4772 2850480 SGTC_2172 5754775 163.918 µM -2.71018638302012 0.00371180843456002 no 3310 0.00336227043332202 4772 2263357 SGTC_3016 9080866 49.47 µM -2.71266024189018 0.00368459171763889 no 3311 0.00333727509343632 4780 17066299 SGTC_1615 st002656 86.5 µM -2.71743655030875 0.00363255007243574 no 3312 0.00328948841741415 4784 1584458 SGTC_1027 k015-0025 8.67 µM -2.74825240215917 0.00331235310239859 no 3313 0.00299569336574805 4762 3598955 SGTC_2127 5253358 187.912 µM -2.82214063880069 0.00264553220366664 no 3314 0.00238521260948468 4762 20612 SGTC_1567 st069303 68.4 µM -2.83756206472212 0.00252269158205968 no 3315 0.00227297538718835 4774 5581319 SGTC_250 brefeldin a 552.239 µM -2.84946702040048 0.00243141458475889 no 3316 0.00218962728265451 4793 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_525 k781-2675 26.7 µM -2.86496209739792 0.00231708937289091 no 3317 0.00208529579074668 4761 3651118 YDL195W SEC31 SGTC_2323 6148992 148.28 µM -2.87565391768272 0.00224106546296732 no 3318 0.0020159575766142 4765 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_385 1494-0393 12.4 µM -2.91378339755132 0.0019879945788249 no 3319 0.00178538783690987 4786 3090647 SGTC_921 1561-0023 372 µM -2.93895893025813 0.00183542902571902 no 3320 0.00164658354338007 4785 24050882 SGTC_2418 pentamidine 31.67 µM -2.97298877943078 0.00164611982746627 no 3321 0.00147457616150389 4766 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3068 9116768 49.47 µM -3.00393067645503 0.00148961273762739 no 3322 0.00133258022088919 4780 41904888 SGTC_717 1532-0246 73.2 µM -3.07964250959734 0.00116222482991016 no 3323 0.00103624596577217 4793 9561992 SGTC_1931 st074438 57.1 µM -3.08270592890194 0.00115048429049613 no 3324 0.00102563875009057 4788 2787313 SGTC_2819 7996655 46.38 µM -3.09267747680964 0.00111301664409021 no 3325 0.000991797925442361 4784 6456960 SGTC_2289 7946404 165.07 µM -3.11811865325748 0.00102243205656742 no 3326 0.000910047563045601 4783 1246120 YPR165W RHO1 SGTC_744 1594-0068 283 µM -3.11966366214468 0.00101715511608183 no 3327 0.000905288236150795 4794 668392 SGTC_816 0325-0417 81.3 µM -3.19557116010533 0.000786674433990303 yes 3328 0.000697771823470167 4800 68101 SGTC_1505 k297-0037 20.6 µM -3.34392771410767 0.000468803041236041 yes 3329 0.000413006284789595 4793 4089396 SGTC_2962 9082311 13.18 µM -3.36581450770767 0.000433583454346509 yes 3330 0.000381590050990606 4786 16459453 SGTC_1693 xanthone 101.9 µM -3.37656797954837 0.000417193125535696 yes 3331 0.000366981162426347 4807 7020 An insecticide. SGTC_368 fentichlor 4.58 µM -3.38681944054169 0.000402104815257744 yes 3332 0.000353539533881509 4793 7329 A pesticide. SGTC_1504 k297-0033 30 µM -3.50161774205026 0.000264412439664615 yes 3333 0.000231221293428645 4788 4388117 SGTC_1465 k213-0056 144 µM -3.51575477794755 0.000250895135179158 yes 3334 0.000219252899809949 4777 24048857 YMR208W ERG12 SGTC_2601 securinine 100 µM -3.62991141847224 0.000163112720589098 yes 3335 0.000141759250101128 4793 442872 A GABA receptor antagonist. SGTC_244 nsc-207895 1.295 µM -3.68511342890862 0.000131872891496333 yes 3336 0.000114300404479781 4778 42640 SGTC_1174 0739-0097 51.1 µM -3.68567425097106 0.000131586430668876 yes 3337 0.000114048976469059 4807 728447 SGTC_1841 st054148 70 µM -3.73162935836024 0.000109998478149058 yes 3338 9.51226374084858e-05 4808 675442 SGTC_527 4476-4215 268 µM -3.74653916962261 0.000103741331959702 yes 3339 8.96455093828601e-05 4806 4418754 SGTC_924 2046-0044 21.3 µM -3.76877204563164 9.50289105918702e-05 yes 3340 8.20263107074059e-05 4794 3623589 SGTC_914 3820-6779 408 µM -3.79141160969091 8.68670759804075e-05 yes 3341 7.48967300967804e-05 4790 2893481 SGTC_1712 st032288 53.4 µM -3.81156614627518 8.01602739753806e-05 yes 3342 6.90445459138689e-05 4755 2883011 SGTC_767 0929-0023 86 µM -3.81553654679175 7.8897848842602e-05 yes 3343 6.79436705149806e-05 4806 1204563 SGTC_923 1900-2434 73.3 µM -3.83331706577148 7.34704530900003e-05 yes 3344 6.32134139066975e-05 4791 5910570 SGTC_613 3914-0030 117 µM -3.84009768443662 7.1494871980422e-05 yes 3345 6.149268215938e-05 4747 1145395 SGTC_2405 ticlatone 3.52 µM -3.98163881963393 4.00743836714196e-05 yes 3346 3.42208643184578e-05 4759 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3132 9126706 49.47 µM -4.01452713198291 3.49360122742458e-05 yes 3347 2.97825459551063e-05 4802 850858 SGTC_2834 9001755 58.44 µM -4.09999824418238 2.4340050760106e-05 yes 3348 2.06576636403011e-05 4771 2989575 SGTC_630 4356-0227 183 µM -4.23081841003874 1.38124986326685e-05 yes 3349 1.16421294835828e-05 4807 779312 SGTC_1107 amlodipine 47 µM -4.89647656468483 6.00722643689637e-07 yes 3350 4.87851390616968e-07 4715 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1776 st049249 45.9 µM -5.36061864808036 5.25090876567534e-08 yes 3351 4.14687167102373e-08 4809 1822314 SGTC_1926 methyl fluorone black 53.6 µM -5.70814744538881 7.3916693122915e-09 yes 3352 5.71062305371484e-09 4795 72721 Reacts with homocysteine. SGTC_750 4073-0104 132 µM -7.63384347161984 1.69333145400647e-14 yes 3353 1.13928270194408e-14 4808 22330957 SGTC_2592 piperlongumine 83.33 µM -7.93688890234204 1.57856472915468e-15 yes 3354 1.0365779472715e-15 4810 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2593 nobiletin 86.24 µM -8.77797982361305 1.36057540943109e-18 yes 3355 8.32185607163259e-19 4810 72344 An anti-infammatory. SGTC_2600 tangeritin 87.95 µM -10.4184011754616 1.94809249168724e-25 yes 3356 1.0217980654587e-25 4810 68077 A bioactive flavone.