SGTCid condition conc unit MEK1|YOR351C.score MEK1|YOR351C.strain.pval MEK1|YOR351C.strain.significant MEK1|YOR351C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_961 1252-1571 372 µM 6.37992832341963 2.6662528521835e-12 yes 1 8.85854432162592e-11 7 6813498
SGTC_2800 7887935 81.82 µM 4.92428540917967 5.25764953042761e-08 yes 2 4.23345922520776e-07 8 2961002
SGTC_1480 1070-0044 41.2 µM 4.71571158979018 1.77753169553066e-07 yes 3 1.20433714839943e-06 5 3124987
SGTC_159 3970-0959 50 µM 4.52363794446151 5.22343662593076e-07 yes 4 3.03928353473663e-06 52 6615653
SGTC_913 3487-1245 167 µM 4.52228587607509 5.26243957290998e-07 yes 5 3.05876798731661e-06 14 4016153
SGTC_1802 st050112 57.9 µM 4.39309168819082 1.06105846062868e-06 yes 6 5.58749843401155e-06 6 4662563
SGTC_307 1501-1223 22.3 µM 4.08219192195126 5.30827134364798e-06 yes 7 2.23064652438704e-05 12 2830329
SGTC_947 3447-0010 211 µM 3.9824729106778 8.69300991648854e-06 yes 8 3.41009502630145e-05 12 748350
SGTC_1068 loratadine 26.9 µM 3.92012294202702 1.17662128823787e-05 yes 9 4.42519037668235e-05 22 3957 A H1 histamine antagonist.
SGTC_3234 9132280 49.47 µM 3.91389783694866 1.21243392670284e-05 yes 10 4.54090363470379e-05 20 17612295
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.89968749367705 1.29811032707697e-05 yes 11 4.81584629542945e-05 51 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2755 lomerizine 42.69 µM 3.84097028846374 1.71709262285194e-05 yes 12 6.12744742311946e-05 28 3949 A calcium channel blocker.
SGTC_1578 josamycin 24.2 µM 3.66544685605192 3.87176719317737e-05 yes 13 0.000123453541137292 18 5282165 A P450 substrate.
SGTC_1093 fluphenazine 7.97 µM 3.49154295460531 8.37493257855557e-05 yes 14 0.000240119619407828 24 6602611 An atypical antipsychotic.
SGTC_594 1487-1584 10.8 µM 3.48654673447964 8.55836762624446e-05 yes 15 0.000244649941573424 36 5013332
SGTC_2405 ticlatone 3.52 µM 3.45022807933191 0.000100098601868021 yes 16 0.000280056559459524 89 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_952 1185-0122 232 µM 3.40290111310768 0.000122497954983042 yes 17 0.000333372036211858 39 678600
SGTC_2982 9019404 25.97 µM 3.3547809116889 0.000150033654199298 yes 18 0.000397139316478817 39 22333232
SGTC_3107 9121808 49.47 µM 3.32851890980803 0.000167407949991929 yes 19 0.00043654538841476 17 662681
SGTC_1636 st007707 68.9 µM 3.32839216700551 0.000167496189607207 yes 20 0.000436744063047043 72 403051
SGTC_2466 5983409 37.09 µM 3.32683599459318 0.000168583165959183 yes 21 0.000439190271489365 39 2879657
SGTC_1191 1487-1166 10.6 µM 3.26159842282493 0.000220563015847711 yes 22 0.000553929827962757 53 3955771
SGTC_2986 9022445 71.43 µM 3.25599163264627 0.000225667069156411 yes 23 0.000564985407375375 35 6459286
SGTC_2045 5106652 78.05 µM 3.21967295332869 0.0002614928353957 yes 24 0.000641684592650904 39 673349
SGTC_864 0469-0573 172 µM 3.21444789189829 0.000267063052708468 yes 25 0.000653478169573614 46 689425
SGTC_945 3381-0768 11.3 µM 3.21181908939471 0.000269907128049776 yes 26 0.000659487025909549 61 1126236 YIL048W NEO1
SGTC_2585 alliin 100 µM 3.16348962145723 0.000327492254008323 yes 27 0.000779449549816257 62 87310 A garlic compound which reacts with lipids.
SGTC_872 0588-0139 234 µM 3.11908792175111 0.000390276507155887 yes 28 0.000907059096984648 66 2047100
SGTC_943 3253-1379 105 µM 3.09664438119173 0.000426102656643271 yes 29 0.000978622606863955 57 668464
SGTC_588 3970-1144 52.9 µM 3.0617499568924 0.000487905744304685 yes 30 0.0011002359182541 66 1888707
SGTC_493 zm226600 134 µM 3.03193335981367 0.000547186696233923 yes 31 0.00121496421428532 50 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1500 4488-1866 171 µM 3.0006557690498 0.000616478317155198 yes 32 0.00134699461970427 60 2900003
SGTC_1602 st001878 87.6 µM 2.98259336504539 0.000660097703588932 yes 33 0.00142908728597563 58 595405 YLR310C CDC25
SGTC_2047 4141938 200 µM 2.97067551860611 0.000690419411924096 yes 34 0.00148572776693712 30 3807862
SGTC_2378 9074213 121.43 µM 2.93727369752725 0.000782378426514443 yes 35 0.00165555867487458 77 657714
SGTC_1204 4049-0315 18.3 µM 2.92912613189244 0.000806458753114701 yes 36 0.00169958228547986 86 588402
SGTC_7 0192-1582 4.227 µM 2.90952127837981 0.000867223368496802 yes 37 0.00180991372537643 142 252616
SGTC_1502 4534-4282 27.7 µM 2.87395547639124 0.000988318403655935 yes 38 0.00202683052102042 54 3278949
SGTC_344 k064-0035 6.43 µM 2.86867734897683 0.00100755750159787 no 39 0.00206096020701233 71 5088750
SGTC_1404 3909-7820 48.3 µM 2.84177374112495 0.00111107216123543 no 40 0.0022431659260514 51 23741373
SGTC_409 arachidonic acid 100 µM 2.83355908083414 0.00114456908945137 no 41 0.00230163989283845 57 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1493 4348-0038 111 µM 2.78447792395753 0.00136473162136747 no 42 0.00268069853023466 97 800424
SGTC_3123 9126162 49.47 µM 2.76741515101217 0.00144990998201782 no 43 0.00282513757322246 70 25239884
SGTC_1509 1326-1131 80 µM 2.753391886074 0.00152351769415376 no 44 0.00294906237265645 54 768313
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.74091415452347 0.00159186149424937 no 45 0.00306342563994155 90 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_364 0083-0097 67.7 µM 2.7320898346394 0.00164186892677959 no 46 0.00314669892142617 94 5207356
SGTC_1444 4112-3581 28 µM 2.72645234381522 0.00167456142167194 no 47 0.00320095982845775 74 2877249
SGTC_3 0833-0587 95.581 µM 2.72092439566322 0.00170719322132842 no 48 0.00325498242738489 76 5382644
SGTC_765 1319-0117 244 µM 2.71630044388114 0.00173493215615489 no 49 0.00330079897824318 67 3487746 YGL099W LSG1
SGTC_442 cape 100 µM 2.70359510080719 0.00181327608927824 no 50 0.00342969081386316 61 5281787
SGTC_1294 1000-1494 117 µM 2.70159818251124 0.0018258780221602 no 51 0.00345035513568403 93 712797 YDL207W GLE1
SGTC_98 0074-0023 107.663 µM 2.69688088807018 0.00185596428655413 no 52 0.00349961506526893 112 3563821
SGTC_2320 7373003 200 µM 2.67707186856248 0.00198728530556809 no 53 0.00371343511477452 88 5415828
SGTC_135 0933-0004 26.348 µM 2.65198173994056 0.00216570872999882 no 54 0.00400104346814886 96 21230617 YGL099W LSG1
SGTC_992 3909-8734 162 µM 2.64491369211149 0.00221852952168861 no 55 0.00408558779153134 97 4288319
SGTC_1657 st012939 43.4 µM 2.64088597821823 0.00224914892999111 no 56 0.0041344771602729 68 24207257
SGTC_405 ebelactone b 50 µM 2.63993423549079 0.0022564399489913 no 57 0.00414610583119619 97 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2420 aureobasidin a 50 nM 2.63692512417665 0.00227963294812237 no 58 0.00418306479452247 136 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2379 9035213 200 µM 2.63011792932109 0.00233289872980892 no 59 0.00426776266923771 102 646551
SGTC_1088 bifonazole 369 nM 2.61835272419281 0.00242762343757755 no 60 0.00441777111967071 80 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2178 5812956 200 µM 2.61343521589962 0.00246823650249081 no 61 0.00448185378908563 87 5403383
SGTC_2910 7948405 25.97 µM 2.61048453458623 0.00249289980323204 no 62 0.0045207029998006 92 2971328
SGTC_60 0986-0278 202 µM 2.59180987922319 0.00265422826870298 no 63 0.00477362582618683 68 3110598
SGTC_1935 st074532 41.6 µM 2.58906634361125 0.00267870784198243 no 64 0.00481182757099047 135 2829742
SGTC_1805 st050013 60.3 µM 2.58590107570104 0.00270720354282817 no 65 0.00485624006600679 68 4037144
SGTC_2832 7992762 51.95 µM 2.57530951690312 0.00280455633617647 no 66 0.00500752101473915 112 2985177
SGTC_1550 gossypolone 36.6 µM 2.57365069719547 0.00282008631079554 no 67 0.00503159061899399 106 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2414 st077232 92.9 µM 2.57292599535564 0.0028268953314726 no 68 0.00504213839938314 108 729801
SGTC_2151 5563267 85.4165 µM 2.56576121663645 0.00289501522792588 no 69 0.00514748360407293 112 5310824
SGTC_732 3970-1727 52.7 µM 2.55201853166476 0.00302983120731878 no 70 0.00535504109982066 78 1275699
SGTC_3278 9139605 49.47 µM 2.5456276783337 0.00309443110578995 no 71 0.00545407322462376 86 7958859
SGTC_1390 3413-2614 145 µM 2.52591362185595 0.0033015912490272 no 72 0.00576989251634767 122 3421432
SGTC_1115 galangin 695.678 nM 2.51726445579455 0.00339635155878622 no 73 0.00591350099733719 109 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1078 idebenone 36.1 µM 2.49942278987643 0.00359958409184479 no 74 0.00621979014113347 162 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2044 5102272 200 µM 2.49745635615772 0.0036226384597915 no 75 0.00625439309490367 83 592666
SGTC_766 1391-0721 126 µM 2.49219797521248 0.00368493975243664 no 76 0.00634776258613379 113 1020919 YIL115C NUP159
SGTC_2841 9004761 38.96 µM 2.48276972712044 0.00379905646247872 no 77 0.00651826650886919 122 2991039
SGTC_104 0074-0074 590.992 µM 2.48194892742966 0.00380913954400433 no 78 0.00653330009531623 48 3943124
SGTC_2453 5731132 22.18 µM 2.46506463219569 0.00402194632214202 no 79 0.00684942694591233 135 1362040
SGTC_3052 9092717 49.47 µM 2.46318951464843 0.00404622483934239 no 80 0.00688535533341171 138 25237534
SGTC_2949 9072542 2.23 µM 2.45845574708883 0.0041081010731955 no 81 0.00697679861123471 164 16457352
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.44715264719552 0.00425928450235609 no 82 0.00719949208055047 128 5393153
SGTC_3328 9140624 29.0385 µM 2.43274384606765 0.00445921120139755 no 83 0.00749244885784525 127 4904392
SGTC_1279 0874-0590 65.2 µM 2.42430187511118 0.00458020219551069 no 84 0.00766892495741951 131 3523074
SGTC_2083 5306046 65.942 µM 2.42371172932655 0.00458876878610924 no 85 0.00768139746274734 164 539837
SGTC_2593 nobiletin 86.24 µM 2.42092498858997 0.00462941479195074 no 86 0.0077405357127339 130 72344 An anti-infammatory.
SGTC_3164 9100705 49.47 µM 2.40467829341633 0.00487284091666189 no 87 0.0080933540883661 72 17174235
SGTC_371 0195-0006 7.36 µM 2.40216514874179 0.00491149764674056 no 88 0.00814917423446522 108 3928593
SGTC_3299 9121982 43.1275 µM 2.40110624758711 0.00492786713158292 no 89 0.00817279489272401 148 17594604 YPL160W CDC60
SGTC_1233 0325-0408 14.2 µM 2.37635590601587 0.00532458600490147 no 90 0.00874229448530927 120 12874
SGTC_3062 9077494 49.47 µM 2.37302168856995 0.00538014523644697 no 91 0.00882161394212409 143 16459633
SGTC_2107 5363541 170.161 µM 2.33740201746887 0.00600663724944959 no 92 0.00970914516711444 129 244052
SGTC_1754 st042065 16.137 µM 2.33487499603467 0.00605344705775963 no 93 0.00977497595835774 343 1126236 YIL048W NEO1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.31976616972923 0.00634012283717229 no 94 0.0101767650489349 125 4213774
SGTC_1796 st049173 110.4 µM 2.31063375058819 0.00651917128265401 no 95 0.0104265466887101 85 94134
SGTC_73 0327-0325 16.231 µM 2.30763999937525 0.00657883189069798 no 96 0.010509583913375 227 53298
SGTC_2331 7980721 200 µM 2.3065320988259 0.00660103264224238 no 97 0.0105404593450204 153 2981221
SGTC_2385 9074692 200 µM 2.30523804184095 0.00662704755281774 no 98 0.0105766226995807 168 17046906
SGTC_3007 9078383 71.4286 µM 2.29720026670561 0.00679067324718022 no 99 0.0108036739651599 147 6496995
SGTC_1254 0550-0035 264 µM 2.28391309870512 0.00706899642937327 no 100 0.0111883193315946 159 15121435
SGTC_2128 5255449 168.493 µM 2.28370312603136 0.00707347430748114 no 101 0.0111944921104901 188 736008
SGTC_3082 9117008 49.47 µM 2.27391730762767 0.00728496289145335 no 102 0.0114854794355664 132 41448529
SGTC_2628 lathosterol 100 µM 2.26908387892098 0.00739146382595319 no 103 0.011631612764268 165 6710616
SGTC_3263 9137018 49.47 µM 2.26354311326482 0.00751523637049449 no 104 0.0118011150313155 152 43844957
SGTC_2744 captopril 92.04 µM 2.25800139639512 0.00764085266082659 no 105 0.0119727861883741 91 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2335 9018011 154.17 µM 2.25787436674709 0.007643753636183 no 106 0.0119767465693999 175 6458208
SGTC_875 0709-0210 25.7 µM 2.2497719832614 0.00783080269928045 no 107 0.0122317116836662 182 6251364
SGTC_2177 5811945 192 µM 2.21664541409454 0.00863808417594349 no 108 0.0133236658102943 153 5343475
SGTC_1429 4049-0205 9.46 µM 2.21022338949978 0.00880277039912008 no 109 0.0135448312342771 165 22774478
SGTC_2518 prenyletin 46.28 µM 2.20732729485843 0.00887793383186516 no 110 0.013645600862123 89 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_3284 9108171 64.8615 µM 2.19329434286126 0.00925015550727882 no 111 0.0141430894873669 141 8687505
SGTC_2955 9076254 12.21 µM 2.19279121160036 0.00926375089106365 no 112 0.0141612127127802 135 16459619
SGTC_3090 9117696 49.47 µM 2.18771724892759 0.00940183749742905 no 113 0.0143451024138338 132 7923821
SGTC_653 0203-0016 55.2 µM 2.18605941583292 0.00944734356936603 no 114 0.0144056293368614 176 295302
SGTC_2340 7987427 183.45 µM 2.18480219013235 0.00948198162900709 no 115 0.0144516767030098 172 2239331
SGTC_1701 st028638 40.4 µM 2.18093316248927 0.00958927560364401 no 116 0.0145941802183349 167 3490878
SGTC_960 1222-0186 7.7 µM 2.18004466288481 0.00961406435196432 no 117 0.014627075520082 182 3126296
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.17429468229642 0.00977584445368468 no 118 0.0148415057646452 206 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_772 k072-0172 35.3 µM 2.16332782285251 0.0100910083626248 no 119 0.0152579873005422 164 5861980
SGTC_2662 daunorubicin 22.37 µM 2.14497617169449 0.0106382460072948 no 120 0.0159773761032596 161 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1170 0310-0127 64.8 µM 2.12968563428999 0.0111137658098413 no 121 0.0165987878979013 209 774975
SGTC_2520 obtusaquinone 4.71 µM 2.12793309402994 0.0111694312549879 no 122 0.0166713156195166 162 5967872
SGTC_151 3013-0144 2.285 µM 2.11435629812365 0.0116089403247264 no 123 0.0172424236359148 196 906558 YHR107C CDC12
SGTC_14 0354-0009 295 µM 2.11072450102298 0.0117290249998334 no 124 0.0173979993894187 192 1713507
SGTC_2817 7995342 71.43 µM 2.1098023580321 0.0117596865642748 no 125 0.0174376916419143 171 18879975
SGTC_2477 5967686 25.23 µM 2.10857976189813 0.0118004455310029 no 126 0.0174904356446306 185 776118
SGTC_1160 4092-0570 10.5 µM 2.1039280941661 0.0119566455377277 no 127 0.0176923599389513 226 4994975
SGTC_2074 5212007 75.395 µM 2.1028484923648 0.0119931532123875 no 128 0.0177395077709273 159 758611
SGTC_2954 9074818 52.69 µM 2.09991632871689 0.0120927950806413 no 129 0.0178681010500629 206 16648742
SGTC_3240 9133527 49.47 µM 2.09648417595253 0.0122103387518366 no 130 0.0180196311006076 157 17617455
SGTC_160 3453-0671 289.699 µM 2.09500871128439 0.012261173709062 no 131 0.0180851090506197 213 5322268
SGTC_2455 5377712 9.75 µM 2.09163944594025 0.0123779447457696 no 132 0.018235390553056 181 2243908
SGTC_975 1335-0046 28.5 µM 2.0868314793433 0.0125462453770528 no 133 0.0184516852525796 234 16486740
SGTC_3232 9132874 49.47 µM 2.07795599772083 0.0128621357653894 no 134 0.0188567060658505 173 3784940
SGTC_1816 st051957 91.6 µM 2.06853744952081 0.0132048550393431 no 135 0.0192947564370063 170 674121
SGTC_636 0kpi-0074 126 µM 2.06740666176512 0.0132465275946518 no 136 0.0193479255278146 175 616434
SGTC_763 3453-1109 128 µM 2.06078843802802 0.013492712270325 no 137 0.0196616139994358 202 1560353
SGTC_2676 harmalol 100 µM 2.05582051774454 0.0136800948691793 no 138 0.0198999097879205 182 5459187 A monoamine oxidase inhibitor
SGTC_1671 st016596 74.5 µM 2.05414295295246 0.0137438752140629 no 139 0.0199809289236785 207 2829167
SGTC_2787 5284540 71.43 µM 2.04863327760106 0.0139551588394432 no 140 0.0202489940354719 218 736958
SGTC_1644 st010134 20.9 µM 2.04287661143881 0.0141788994321151 no 141 0.0205323270719592 164 3818134
SGTC_2341 7987486 176.74 µM 2.03523290716391 0.0144807536299546 no 142 0.0209137217028629 232 1258686
SGTC_2849 9019321 12.99 µM 2.03087904152592 0.0146551506820824 no 143 0.0211336331662217 234 16489627
SGTC_2220 6782180 200 µM 2.01798598596395 0.0151822284459019 no 144 0.0217963604321286 121 833803
SGTC_3346 9158254 43.5805 µM 1.99517372888589 0.0161547534611705 no 145 0.0230119676332918 216 17639500
SGTC_826 1683-5028 118 µM 1.99491051976263 0.0161662789700105 no 146 0.0230263199848177 192 722377
SGTC_233 rapamycin 362 pM 1.98087481778449 0.0167911689395115 no 147 0.0238026568788078 200 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2963 9082507 9 µM 1.97846892723072 0.0169003311062202 no 148 0.0239379153049183 212 16459611
SGTC_2322 7413319 38.22 µM 1.97679590360519 0.0169765982235141 no 149 0.0240323524652792 430 1840400
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.97574930709037 0.0170244582432504 no 150 0.0240915887136473 226 521171
SGTC_1428 4049-0204 61.7 µM 1.97338934285801 0.0171328009288783 no 151 0.0242256104330721 215 X1428
SGTC_53 0973-0023 39.979 µM 1.97151080851005 0.0172194625042353 no 152 0.0243327389697546 206 674768
SGTC_1230 0170-0365 3.77 µM 1.97063616618354 0.0172599395953424 no 153 0.0243827533838397 369 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1157 4092-0394 27.6 µM 1.96560754765282 0.0174942366913007 no 154 0.024671980790208 262 3659885
SGTC_2783 7738165 71.43 µM 1.95722382381097 0.0178908946803614 no 155 0.025160579503888 194 17201110
SGTC_2697 mebhydrolin 72.4 µM 1.95517475703165 0.0179890001864911 no 156 0.025281223480732 305 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2794 7785382 27.27 µM 1.94652534052935 0.0184081883911678 no 157 0.025795833514497 309 2205081
SGTC_2342 7990637 118.86 µM 1.94543604970882 0.0184615654094044 no 158 0.0258612597486456 260 2033102 YER133W GLC7
SGTC_725 1497-0963 19 µM 1.9363268411673 0.0189131132418897 no 159 0.0264138416992648 211 3549977
SGTC_1667 st014849 34.6 µM 1.93588235048838 0.0189353851865862 no 160 0.0264410559312539 197 5348460
SGTC_2029 5175081 200 µM 1.92906826095227 0.0192796186890749 no 161 0.0268611942937628 268 1380876
SGTC_3071 9117417 49.47 µM 1.92748939777051 0.0193601341268638 no 162 0.0269593340443334 168 45595590 YGL055W OLE1
SGTC_1972 st070201 17.4 µM 1.92716797716028 0.0193765601925216 no 163 0.0269793496874045 240 2829099
SGTC_2700 st077718 96.8 µM 1.92624361149432 0.019423865522215 no 164 0.0270369813255428 187 904970
SGTC_2513 baicalein 25.65 µM 1.91710109853237 0.0198970498114022 no 165 0.0276125445561699 233 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_603 3794-0023 45.9 µM 1.9025553769883 0.0206700339771896 no 166 0.0285492932414002 209 3802260
SGTC_656 4090-1979 187 µM 1.90108732861127 0.0207494429184386 no 167 0.0286452875242281 273 22330961
SGTC_1009 4106-0057 9.87 µM 1.89911192820186 0.0208567028364135 no 168 0.0287748805524665 241 2928005
SGTC_2133 5320837 200 µM 1.89198396415277 0.0212476464180634 no 169 0.0292465587054592 242 2841355
SGTC_221 trifluoperazine 10.304 µM 1.89178846568656 0.021258455552741 no 170 0.0292595853557277 472 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2067 5224629 34.075 µM 1.88322073702043 0.0217367551697224 no 171 0.0298352299452496 275 2835000
SGTC_1141 3253-0389 52.6 µM 1.88125380363392 0.021847834610261 no 172 0.0299687009495613 218 5402031
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.87490120640282 0.0222098671734679 no 173 0.0304031580383206 281 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_712 r015-0009 80.6 µM 1.86747765591306 0.0226393344180889 no 174 0.0309174571323095 227 6813872 YLR060W FRS1
SGTC_1012 4112-3522 18 µM 1.8659871262648 0.0227264031631549 no 175 0.0310215833287914 266 3112398
SGTC_976 1348-1067 47.6 µM 1.85051480934486 0.0236469989860774 no 176 0.0321196927877125 291 5310671 YGL099W LSG1
SGTC_1562 morin hydrate 59.1 µM 1.84351541522044 0.0240736502447975 no 177 0.0326268965634979 261 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2112 5488546 200 µM 1.83294387979048 0.024730291602991 no 178 0.0334054586642859 289 600757
SGTC_1983 st071813 46.9 µM 1.83101884004277 0.0248514664502478 no 179 0.0335488655398454 266 11838595
SGTC_2696 st077691 74.316 µM 1.82982368081572 0.0249269479955095 no 180 0.0336381542729827 256 757133
SGTC_1151 3909-8316 15.3 µM 1.8233753319176 0.0253375244763232 no 181 0.0341232819116044 285 800431
SGTC_3233 9132340 49.47 µM 1.80958635600232 0.0262345225033907 no 182 0.0351799786762237 256 17682950
SGTC_906 1165-0455 526 µM 1.79886271466422 0.0269503329716937 no 183 0.0360201999175736 247 3252859
SGTC_1804 st050076 49.1 µM 1.79467671106517 0.0272341412081559 no 184 0.0363526115827014 274 3895976
SGTC_2524 avocatin b 10.57 µM 1.79355477746971 0.0273106298276233 no 185 0.0364421300400607 241 6710748
SGTC_2745 rifampicin 24.3 µM 1.79291121535024 0.0273545859429243 no 186 0.0364935608686906 154 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_56 0957-0365 83.25 µM 1.78195588956105 0.0281119446764017 no 187 0.0373782126333041 321 6752360
SGTC_997 3996-0078 137 µM 1.77931989867332 0.0282967578427845 no 188 0.0375936652219436 316 735687
SGTC_1143 3454-2408 5.08 µM 1.76823551129692 0.0290850013492562 no 189 0.0385107699155122 208 X1143
SGTC_1008 4106-0037 6 µM 1.76109649351169 0.0296022730493184 no 190 0.0391110362135704 266 2905394
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.75089937610888 0.030354347105347 no 191 0.0399816221472514 314 2333 A French combination drug.
SGTC_1085 doxorubicin 7.67 µM 1.74650406590222 0.0306833652302044 no 192 0.0403617005894162 345 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1490 4089-0339 670 nM 1.74500409092762 0.0307963219669784 no 193 0.040492078431314 224 742542
SGTC_2315 7733312 200 µM 1.73700001003195 0.0314049095123821 no 194 0.0411935845495834 279 726316
SGTC_472 calcifediol 10 µM 1.7367987195871 0.0314203418279299 no 195 0.0412113525770564 230 5283731 A vitamin D metabolite.
SGTC_326 k292-0812 17.5 µM 1.73628223352785 0.0314599679006713 no 196 0.0412569715349416 252 3579357
SGTC_2905 7799065 20.05 µM 1.73213397902649 0.0317797328662751 no 197 0.0416248552699905 262 1296806
SGTC_1354 1498-1681 81 µM 1.72344301705141 0.0324583781838026 no 198 0.0424042207324917 327 5754243
SGTC_2877 9040724 71.43 µM 1.72237071625545 0.0325429327451957 no 199 0.04250119245554 274 6463895
SGTC_2092 5303694 80.6725 µM 1.72102748232427 0.0326491075642335 no 200 0.0426229185127311 341 1963699
SGTC_2053 5265679 138 µM 1.71208264679079 0.0333634517314709 no 201 0.0434407194227022 345 764595
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.7056643641759 0.0338839135366325 no 202 0.0440352940806484 361 6708561
SGTC_1132 3456-3614 2.5 µM 1.70418731242849 0.0340046289840359 no 203 0.0441730493775746 418 3125502
SGTC_502 l-744,832 89.3 µM 1.69755730080103 0.034550846240785 no 204 0.0447956737908623 323 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1340 1486-1359 257 µM 1.69143776498906 0.0350613843062066 no 205 0.0453766123302953 325 4309068
SGTC_2589 lobaric acid 100 µM 1.68740403108042 0.0354012820163936 no 206 0.0457628446267127 335 73157 A novel microtubule depolymerizer.
SGTC_660 4031-1742 102 µM 1.68618441849496 0.0355045816071881 no 207 0.0458801420439721 374 6738706
SGTC_506 n9-isopropylolomoucine 153 µM 1.68445278322026 0.0356516732651745 no 208 0.0460470986258814 308 6610355
SGTC_1633 st005664 67.9 µM 1.68237474964244 0.0358288482617905 no 209 0.0462480972720387 360 2063822
SGTC_1927 st060202 13.8 µM 1.68227818514705 0.0358370989464752 no 210 0.0462574546154548 309 688887
SGTC_816 0325-0417 81.3 µM 1.67384221257042 0.0365639178655355 no 211 0.0470808068738833 297 68101
SGTC_949 1165-0505 146 µM 1.67085431218549 0.0368242212864492 no 212 0.0473752288370238 374 6244267
SGTC_2837 9008476 45.46 µM 1.67077090022064 0.0368315097540827 no 213 0.0473834692119808 379 2992805
SGTC_2066 5222451 176 µM 1.66968764965715 0.0369262704583907 no 214 0.0474905892674992 406 2281147
SGTC_1418 3966-3099 2.4 µM 1.66645259735708 0.0372104537540424 no 215 0.0478116510743633 359 740335
SGTC_1501 4491-0275 38.4 µM 1.66596186008203 0.0372537182826151 no 216 0.0478605056051592 300 5104718
SGTC_3051 9093778 49.47 µM 1.66582179519006 0.0372660742626045 no 217 0.0478744568606954 244 17217378
SGTC_2511 berberine 10.47 µM 1.662282639249 0.0375793975944589 no 218 0.0482280585266726 306 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1442 4112-3290 3 µM 1.65991592792248 0.0377901214474371 no 219 0.0484656833617979 360 704353
SGTC_2751 anetholtrithion 17.25 µM 1.65704023947252 0.0380474596150597 no 220 0.0487556699511626 360 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_936 3005-4620 401 µM 1.65591070651517 0.0381489289230011 no 221 0.0488699515510958 375 777207
SGTC_585 0kpi-0023 191 µM 1.64737542132846 0.0389228335725078 no 222 0.0497404520697122 316 64601
SGTC_1010 4112-3296 15.2 µM 1.64131916988708 0.0394796781144779 no 223 0.0503655894100295 393 704384
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.6360609038382 0.0399683915782891 no 224 0.0509134207647841 381 5377381
SGTC_2353 9059630 146.67 µM 1.63545445019467 0.0400250714180935 no 225 0.0509769079575109 303 4779114
SGTC_2505 galangin 7.89 µM 1.63409297041992 0.0401525547708365 no 226 0.0511196653325034 271 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1930 st074634 34.3 µM 1.63301098787293 0.0402541022279878 no 227 0.0512333428723879 375 684253 YOR116C RPO31
SGTC_287 k060-0039 29.6 µM 1.62453382054158 0.0410569496745695 no 228 0.0521309641823215 335 5861974
SGTC_559 1550-0661 158 µM 1.62347503757329 0.0411581298417463 no 229 0.0522439476760496 338 5830875
SGTC_1192 1488-0095 21.4 µM 1.61932061329131 0.0415570924705648 no 230 0.0526891488790042 346 915875
SGTC_2360 9040895 200 µM 1.61730199598649 0.0417520747380625 no 231 0.0529065543316974 356 4914414
SGTC_1029 k015-0030 64.7 µM 1.60491938223307 0.0429644037748434 no 232 0.054255773736811 363 2208316
SGTC_3294 9122953 26.2835 µM 1.60423955860559 0.0430317775769839 no 233 0.0543306290619026 368 16459826
SGTC_3022 9087993 49.47 µM 1.59415641248473 0.0440411232134562 no 234 0.0554505031918736 306 17173644
SGTC_446 go6976 132 µM 1.59411617844084 0.044045188644101 no 235 0.0554550079747906 326 3501 A protein kinase C inhibitor.
SGTC_1749 st037932 54.2 µM 1.59354706637156 0.0441027267334171 no 236 0.0555187592533922 373 594497
SGTC_34 0469-0683 81.75 µM 1.59303574330218 0.0441544739371038 no 237 0.0555760864045297 336 3690923
SGTC_1222 0366-0074 1.18 µM 1.59232722279001 0.0442262589198216 no 238 0.0556555996292072 361 286520
SGTC_2193 5925765 200 µM 1.5882658958276 0.0446395562833631 no 239 0.0561131129412281 295 877370
SGTC_971 1315-0384 26.7 µM 1.58805516481526 0.0446610857483247 no 240 0.0561369327379927 372 6769120
SGTC_2279 7948423 32.93 µM 1.58801507310014 0.0446651826900663 no 241 0.0561414653727965 320 1247112
SGTC_1348 1493-0373 93.8 µM 1.57889022751591 0.0456055466495663 no 242 0.0571806189619982 351 3010129
SGTC_757 1066-0008 322 µM 1.57613782442813 0.0458923004885436 no 243 0.0574970218440599 402 6842497
SGTC_1425 4048-4433 7.33 µM 1.56789986436003 0.046759221982107 no 244 0.0584522517312625 432 23734946
SGTC_2 0422-0095 29 µM 1.56701883752739 0.0468527093547594 no 245 0.0585551442759279 276 6790840
SGTC_199 4063-0024 41.6 µM 1.56579731964513 0.0469825748198404 no 246 0.0586980369693634 352 306215
SGTC_3149 9097855 49.47 µM 1.56281714715529 0.0473006226929452 no 247 0.0590478049080928 367 25236625 YMR079W SEC14
SGTC_427 1354-0053 47.3 µM 1.56281603975859 0.0473007411956607 no 248 0.05904793518091 401 6813657
SGTC_866 0495-0101 262 µM 1.55899624253151 0.0477109163271414 no 249 0.0594986347473011 342 635694
SGTC_1227 3909-8010 46.6 µM 1.55692315868532 0.0479347165273445 no 250 0.0597443651636217 367 15982272
SGTC_737 1950-0117 57.9 µM 1.5493318185937 0.0487614224502112 no 251 0.06065098731777 391 5393513
SGTC_2586 curcumin 80 µM 1.5487009460433 0.0488306349552614 no 252 0.0607268131838385 482 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_247 mechlorethamine 29.705 µM 1.5468792465905 0.0490309328288862 no 253 0.0609461831567184 318 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1077 5-fluorocytosine 377 nM 1.54361801452267 0.0493911476778534 no 254 0.0613404491354872 371 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2709 st078560 56 µM 1.53930545497912 0.0498707259581241 no 255 0.0618648714281392 387 17250903
SGTC_1609 st001574 46.4 µM 1.53825637248482 0.0499879490672723 no 256 0.0619929711996832 402 3960012
SGTC_1846 st056244 14.8 µM 1.53569291472056 0.0502753109961914 no 257 0.062306856811995 438 5393182
SGTC_1208 2323-2347 50.3 µM 1.5342981963315 0.0504322101699554 no 258 0.0624781546357934 375 5412760
SGTC_2332 7982454 138.89 µM 1.52058690357678 0.0519955181866506 no 259 0.0641817676858747 457 2981748
SGTC_255 tunicamycin 200.472 nM 1.51700211489288 0.0524105273457306 no 260 0.06463307503571 450 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1246 0422-0085 105 µM 1.51419178100062 0.0527377136725827 no 261 0.0649886028255943 454 264295
SGTC_2391 6285546 200 µM 1.51366103395239 0.052799686162122 no 262 0.0650559163004533 447 846083
SGTC_2160 5660466 132.927 µM 1.51103272386735 0.0531074317514073 no 263 0.0653900568333456 397 2859134
SGTC_1135 dihydrocapsaicin 536.708 nM 1.51102936598674 0.0531078258292206 no 264 0.0653904845749739 434 107982 A Capsaicinoid.
SGTC_2456 5770359 74.46 µM 1.50105815313612 0.0542883009728046 no 265 0.0666702605513239 395 3118787
SGTC_1112 tnp00069 1.16933 µM 1.49951944071153 0.0544723015495031 no 266 0.0668694645882954 478 145826
SGTC_1760 st045453 10.4495 µM 1.49447680357373 0.0550787633382092 no 267 0.0675255201995775 504 3323419 YIL048W NEO1
SGTC_1024 4507-0395 26 µM 1.4877841921459 0.0558918860746028 no 268 0.0684039079226838 426 4201836
SGTC_2312 7706453 155.7 µM 1.48573536384653 0.056142694046442 no 269 0.0686745663762913 431 976098
SGTC_3103 9120822 49.47 µM 1.48339418446645 0.0564303758260323 no 270 0.0689848558188012 447 17141819
SGTC_3200 9114385 49.47 µM 1.47979471705888 0.0568749395480566 no 271 0.0694640194863059 399 17018030 YLR208W SEC13
SGTC_3204 9114183 49.47 µM 1.47877964840102 0.0570008061422933 no 272 0.0695996084204689 421 17027248
SGTC_58 0957-0393 9 µM 1.47852560891559 0.0570323408442118 no 273 0.0696335738891425 768 6997992
SGTC_1091 telmisartan 47.6 µM 1.47596695939852 0.0573507202074852 no 274 0.0699763811484974 445 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3024 9090631 49.47 µM 1.47369623498267 0.0576344420665701 no 275 0.0702816985159742 370 25236383
SGTC_1176 0848-0131 83.3 µM 1.46763939849681 0.0583966302678644 no 276 0.0711011000534157 490 6769040
SGTC_433 pimozide 108 µM 1.46600385795556 0.0586037971397258 no 277 0.0713236179173199 340 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_295 k015-0027 31 µM 1.46578745927302 0.0586312505951281 no 278 0.0713530992975938 415 3887424
SGTC_1030 k029-0042 36.7 µM 1.46538314906257 0.058682570530345 no 279 0.071408206133037 481 6080581
SGTC_2687 chenodiol 100 µM 1.46463098042495 0.0587781386690237 no 280 0.071510812418728 424 5702181 A cholesterol synthesis inhibitor.
SGTC_1064 honokiol 6.76 µM 1.46354894993604 0.0589158321935407 no 281 0.071658614848328 456 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2467 5474540 200 µM 1.46184835155955 0.0591327527446572 no 282 0.0718913854408128 453 5413519
SGTC_1218 1348-1416 30.7 µM 1.45997882364039 0.0593719434912012 no 283 0.0721479469929314 454 6787668
SGTC_2126 5251174 33.877 µM 1.45746321250338 0.0596949915187119 no 284 0.0724942794975986 546 790722
SGTC_1552 6-methylflavone 10.6 µM 1.45497307545601 0.0600161230250078 no 285 0.0728383577611894 384 689013
SGTC_1050 3232-1156 69.3 µM 1.45425663807464 0.0601087659393219 no 286 0.0729375837682809 465 700529
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.45391433552693 0.0601530687814124 no 287 0.0729850289112692 501 23847180
SGTC_1226 3909-7979 35.4 µM 1.45247319530717 0.060339870199154 no 288 0.0731850385185114 498 6615510
SGTC_441 propafenone 146 µM 1.44902196854006 0.0607890656456977 no 289 0.0736657238085438 394 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2939 9044578 71.43 µM 1.44704681996087 0.0610473157777493 no 290 0.0739419054432664 434 2653634
SGTC_959 1222-0044 107 µM 1.44311459193267 0.0615640058876483 no 291 0.0744940967282903 451 6083612
SGTC_102 gallobenzophenone 83.616 µM 1.44057101832907 0.0619000432909561 no 292 0.0748529565064313 482 70837
SGTC_2064 5220758 200 µM 1.43836606953817 0.0621925010256975 no 293 0.0751651073060062 506 788518
SGTC_2102 5377816 72.7585 µM 1.43580718301446 0.0625332540173032 no 294 0.0755286076571146 474 1379702
SGTC_3059 1327-0034 3 µM 1.43547734758016 0.0625772820997004 no 295 0.0755755594297521 475 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1138 3761-0006 1.03 µM 1.43482489437474 0.0626644459887004 no 296 0.075668501048103 413 12061087
SGTC_196 k015-0023 18.111 µM 1.4338278753552 0.0627978245812867 no 297 0.0758106940450115 497 5211998
SGTC_742 0kpi-0133 140 µM 1.43199657201735 0.0630433877482096 no 298 0.0760724011850323 472 2728852
SGTC_3178 9107506 49.47 µM 1.43147287263951 0.0631137490045229 no 299 0.0761473681188966 453 8897194
SGTC_2195 6536160 144.242 µM 1.43092542344671 0.0631873665147227 no 300 0.0762257949135928 399 3834386
SGTC_1656 st012921 11 µM 1.42981955634881 0.0633362804798977 no 301 0.0763844073627816 422 6732821
SGTC_1270 0831-1170 17.3 µM 1.4288279249793 0.0634700438782981 no 302 0.0765268486316741 500 6764716
SGTC_908 3448-7491 47.7 µM 1.42875067543622 0.0634804734681796 no 303 0.076537953493733 574 1203031
SGTC_2671 danthron 100 µM 1.42724482215525 0.0636840477688984 no 304 0.0767546694980039 450 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2749 bexarotene 57.39 µM 1.42692196928009 0.0637277598686978 no 305 0.0768011937947456 471 82146 An retinoic acid receptor inhibitor.
SGTC_1864 st057645 30.4 µM 1.42639110794192 0.0637996856484092 no 306 0.076877739490539 404 688666
SGTC_1041 0206-0046 107 µM 1.42164892618192 0.0644450027056448 no 307 0.0775640969164747 461 50494
SGTC_2436 5633522 8.09 µM 1.41540673436265 0.0653021588805512 no 308 0.0784746381276859 493 5724242
SGTC_926 2268-1401 59.4 µM 1.41499233367774 0.0653593745260288 no 309 0.0785353719020052 485 2931578
SGTC_380 3970-0968 6 µM 1.41303207843792 0.065630551038983 no 310 0.0788231461568735 449 2891601
SGTC_884 0851-0618 334 µM 1.41202140006373 0.0657707060158965 no 311 0.0789718300688688 499 9642473
SGTC_283 0987-0079 11.7 µM 1.41186686749557 0.0657921561235389 no 312 0.0789945825277136 515 411556
SGTC_2123 5259487 200 µM 1.41041267004577 0.0659942737034693 no 313 0.0792089331887981 485 2173474
SGTC_185 k048-0037 25.491 µM 1.403613213305 0.0669457138553963 no 314 0.0802170291481817 488 6827589
SGTC_2738 aclarubicin 5.55 µM 1.40307586792067 0.0670213540527284 no 315 0.0802971082236781 367 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2677 mitomycin C 100 µM 1.40107397603809 0.0673037352057654 no 316 0.0805959763832787 408 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_318 1488-0629 67.2 µM 1.39700730743407 0.0678801988090782 no 317 0.0812056868417825 446 3662576
SGTC_2994 9053520 71.4286 µM 1.39504246485212 0.0681600843856446 no 318 0.0815015172332195 488 4647384
SGTC_2673 kobusone 100 µM 1.39170489184215 0.0686375516443578 no 319 0.0820058901850165 447 6710676 An epoxy ketone and protein crosslinker.
SGTC_227 fluconazole 33.516 µM 1.38927382144092 0.0689869569968096 no 320 0.0823747506042708 544 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1237 0330-0133 46.1 µM 1.38758991840773 0.0692297783530223 no 321 0.082630976550993 453 X1237 YHR072W ERG7
SGTC_2441 5730946 39.09 µM 1.38367875473698 0.0697963145676993 no 322 0.0832284208275931 494 1774275
SGTC_1128 3448-9350 235 µM 1.38291057161358 0.0699080047938886 no 323 0.0833461442003144 436 619386
SGTC_2519 cryptotanshinone 88.04 µM 1.38251160889106 0.0699660663428661 no 324 0.0834073342432123 455 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2993 9054257 71.4286 µM 1.38112968892386 0.0701674657748301 no 325 0.083619544270303 515 6470217 YGL055W OLE1
SGTC_1771 st048882 4.1505 µM 1.3747650970371 0.0711007946823391 no 326 0.0846021410725966 478 4580403
SGTC_320 4092-0846 5.34 µM 1.36817870223253 0.0720766569499871 no 327 0.085628073209864 491 1359356
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.36751102922351 0.0721761520233125 no 328 0.0857325913076388 606 6708739 YPR165W RHO1
SGTC_2358 9037157 4 µM 1.36732345172333 0.0722041233177151 no 329 0.0857619720256024 503 2388925
SGTC_2924 9010168 62.78 µM 1.36411761673567 0.0726834582930707 no 330 0.0862652755470521 524 2993929
SGTC_817 1391-0715 46 µM 1.3595288031834 0.0733738110919746 no 331 0.0869895408554167 468 1353946
SGTC_910 3454-3003 490 µM 1.3551784733095 0.0740329062621512 no 332 0.0876803507266519 536 820824
SGTC_760 0568-0725 82.9 µM 1.35379959752221 0.074242753622138 no 333 0.0879001610611579 519 3916171
SGTC_2424 5537928 59.2 µM 1.35222131693894 0.0744835050712422 no 334 0.0881522631700216 565 5382802
SGTC_1698 5-fluorocytosine 1.055 µM 1.35061583504489 0.0747290168279311 no 335 0.0884092628161045 487 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1197 1601-0112 267 µM 1.3477341318863 0.0751712377469001 no 336 0.0888719549778239 552 7350313
SGTC_1215 3852-0577 11.2 µM 1.347572597212 0.0751960854972697 no 337 0.0888979445787427 575 2884876
SGTC_2764 methyldopa 94.69 µM 1.34673406628589 0.0753251714888766 no 338 0.0890329482407829 530 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.34404773880586 0.0757398503587544 no 339 0.0894664750598982 479 2374 Ca(2+)-ATPase inhibitor.
SGTC_3318 9139014 38.6185 µM 1.34162306442659 0.0761156298138615 no 340 0.0898591219554535 482 16643984
SGTC_3259 9138485 49.47 µM 1.34044981729921 0.0762979700526936 no 341 0.0900495744233286 562 17646153
SGTC_1421 4029-0249 71.4 µM 1.34018156416898 0.076339707272484 no 342 0.0900931618811476 546 2894095
SGTC_1849 st056239 19.2 µM 1.33989815327514 0.0763838217435268 no 343 0.0901392292941754 541 5393181
SGTC_563 tetrahydrosecaminediol 614 µM 1.33920941277336 0.0764911088481698 no 344 0.0902512544983824 537 334274 A psychoactive constituent of the cannabis plant.
SGTC_2851 9015922 71.43 µM 1.33672124667286 0.0768796529594889 no 345 0.0906568219782149 524 2996893
SGTC_570 0987-0065 62.6 µM 1.33250126150973 0.0775420600855542 no 346 0.0913477636009109 404 3104428
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.33231236388556 0.0775718121921628 no 347 0.0913787829975823 486 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1812 st052057 4.327 µM 1.32891577492539 0.0781082683526523 no 348 0.0919378793904566 549 3645418
SGTC_3351 9150312 21.596 µM 1.32831515284301 0.0782034225390769 no 349 0.0920370079783488 533 4904905
SGTC_1305 1181-0477 144 µM 1.32505193748181 0.0787219379401541 no 350 0.0925769628067411 500 6252086
SGTC_740 k014-0057 261 µM 1.32449482858972 0.0788107206711417 no 351 0.0926693797136068 588 4012779
SGTC_1426 4048-4480 71.7 µM 1.32419765280177 0.0788581106123608 no 352 0.0927187050972273 548 14224343
SGTC_2288 7946289 167.31 µM 1.32405812623616 0.0788803680398469 no 353 0.0927418704825167 586 1246052
SGTC_331 k048-0133 24.5 µM 1.32183879970783 0.0792350375717319 no 354 0.0931109176149811 471 6813582
SGTC_2611 pyromycin 23.93 µM 1.31792690757853 0.0798631329090765 no 355 0.0937640586086448 527 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_508 roscovitine 141 µM 1.31138241122515 0.0809223289404161 no 356 0.0948642990894754 531 160355 A CDKinase inhibitor.
SGTC_382 3229-0966 23.2 µM 1.31131554240738 0.0809332058094877 no 357 0.0948755897530725 569 5722370
SGTC_3327 9140648 26.9345 µM 1.30962703892825 0.0812082233634102 no 358 0.095161018364557 520 8029710
SGTC_2248 tofa 1.1 µM 1.30665315263942 0.0816943132742637 no 359 0.0956652679551789 504 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2623 humulene 100 µM 1.30579878318184 0.081834367111302 no 360 0.0958104969932349 464 6187145 An anti-inflammatory.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.30505057163676 0.0819571674136274 no 361 0.0959378140443944 494 279621
SGTC_1755 st041960 45.185 µM 1.30152387657922 0.0825378569256922 no 362 0.096539598600844 531 2257073
SGTC_918 glabranin 770.725 nM 1.30018516126251 0.0827590928031359 no 363 0.096768757579585 564 124049 Also referred to as licorice root.
SGTC_1145 3546-0597 10.2 µM 1.29431025627857 0.0837352568325917 no 364 0.0977791376089715 577 875334
SGTC_3190 9110366 49.47 µM 1.29409060449708 0.0837719208157704 no 365 0.0978170632554809 466 17123768
SGTC_922 1866-0035 480 µM 1.29251478541263 0.0840353080947825 no 366 0.0980894644816705 645 3156169
SGTC_625 k213-0058 121 µM 1.29212512157315 0.0841005334954783 no 367 0.098156908672767 749 3655420
SGTC_1613 st002381 52.1 µM 1.29098097255417 0.0842922709689192 no 368 0.0983551377447841 530 551167
SGTC_2502 avocadyne acetate 18.59 µM 1.29075976584511 0.084329378793522 no 369 0.098393496619418 616 3952079
SGTC_1653 st012112 65 µM 1.28848449347025 0.0847117716251869 no 370 0.0987886816316391 514 720429
SGTC_995 3931-2021 34.6 µM 1.28722206065478 0.0849245020855383 no 371 0.0990084500664936 529 730143
SGTC_2268 7933382 153.85 µM 1.28323160942402 0.0855995600168223 no 372 0.0997054724221892 626 935025 YOR257W CDC31
SGTC_3273 9137859 49.47 µM 1.28098486151889 0.0859814023074351 no 373 0.100099491729968 508 2377234
SGTC_2644 guaiazulene 100 µM 1.27883912625473 0.0863472656928585 no 374 0.100476856313907 529 3515 A coloring agent.
SGTC_626 0214-0009 33 µM 1.27642168638989 0.0867608499067247 no 375 0.100903247092007 589 3437874
SGTC_27 0485-0001 32.618 µM 1.27568353481973 0.0868874300471972 no 376 0.101033705639384 445 2054479
SGTC_2888 9058547 12.99 µM 1.27561378401244 0.0868993982270061 no 377 0.101046039528796 468 16476514
SGTC_1547 harmine 94.2 µM 1.27524686385533 0.0869623764372444 no 378 0.101110939325 632 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3338 9144300 39.5675 µM 1.27279648298473 0.0873838344297667 no 379 0.101545134766757 577 4901274
SGTC_1742 st038235 28.8875 µM 1.26846528901457 0.0881325127645105 no 380 0.102315919438022 592 564103 YBR002C RER2
SGTC_3167 9103034 49.47 µM 1.26535283251016 0.088673469129114 no 381 0.102872437703972 485 5127859
SGTC_2445 5742597 35.57 µM 1.26348090668969 0.0890000054458264 no 382 0.10320820205396 546 1774255
SGTC_1818 st052136 56.3 µM 1.26292339577464 0.0890974297001451 no 383 0.103308355524885 575 674169
SGTC_2326 6164455 177.58 µM 1.26091449707536 0.0894491402374802 no 384 0.103669827239062 523 2888790
SGTC_2482 5981709 142.65 µM 1.2545305224579 0.090573677414123 no 385 0.104824619403146 609 877755
SGTC_649 1123-0311 367 µM 1.25281748410289 0.0908772074702349 no 386 0.105136068581035 643 693629 YIL048W NEO1
SGTC_1789 tunicamycin 25 nM 1.2525156205592 0.090930772226432 no 387 0.105191020016108 563 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.24953993608946 0.0914600522660658 no 388 0.105733828083056 502 77254
SGTC_108 0509-0257 621.132 µM 1.24561343234791 0.0921619428290418 no 389 0.106453174257548 639 536624
SGTC_2914 7968218 45.32 µM 1.24380362364579 0.0924867983383535 no 390 0.106785923210682 547 2977111
SGTC_1007 4101-0031 70 µM 1.24313971901052 0.0926061794791057 no 391 0.106908175773967 607 1146276
SGTC_236 1509-0011 5.31 µM 1.2376484850921 0.0935979683033311 no 392 0.107923214095496 878 3107280
SGTC_1036 k216-0215 33.5 µM 1.23503509782398 0.0940727257371378 no 393 0.108408721028289 625 622330
SGTC_2188 6126565 140.678 µM 1.23411134897062 0.0942409616146579 no 394 0.108580707564248 536 874518
SGTC_1579 chlormadinone acetate 49.4 µM 1.23316102972452 0.0944142680521917 no 395 0.108757845785574 613 45114258 A steroidal progestin.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.23232951125087 0.0945661018832671 no 396 0.108913010084169 569 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2600 tangeritin 87.95 µM 1.23065659318578 0.0948721190515149 no 397 0.109225664564205 573 68077 A bioactive flavone.
SGTC_2261 9010538 184.68 µM 1.23015176160015 0.0949646081125474 no 398 0.109320139931051 509 6457250
SGTC_1003 4049-0218 100 µM 1.22944867711787 0.0950935292907764 no 399 0.10945181459933 621 295161
SGTC_2433 5607874 27.82 µM 1.2291002781446 0.0951574612579926 no 400 0.109517105448854 590 2252428
SGTC_1616 st002734 56.1 µM 1.22834444273016 0.095296267509006 no 401 0.109658847066506 624 4026101
SGTC_3188 9110789 49.47 µM 1.22288639516692 0.0963030442832841 no 402 0.110686303893669 618 849217
SGTC_862 0452-0056 10.2 µM 1.22186659808751 0.0964920169055639 no 403 0.110879039297408 598 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_51 1013-0126 23.419 µM 1.21590520554067 0.0976021412794164 no 404 0.112010517438898 578 1627850
SGTC_191 3914-0123 66.505 µM 1.21413601514569 0.0979333933298582 no 405 0.11234789454168 466 3144412
SGTC_2110 5483698 200 µM 1.20991832016963 0.0987264098749117 no 406 0.113155118323285 606 2848765 YHR062C RPP1
SGTC_1617 st002906 78 µM 1.20943665385715 0.0988172715511946 no 407 0.113247566962309 622 5150859
SGTC_2927 9011802 47.9 µM 1.20372995432104 0.0998984456107195 no 408 0.11434698533993 592 43912568
SGTC_3289 9119912 71.43 µM 1.20204820546122 0.100218706840043 no 409 0.114672425944038 612 17014829
SGTC_265 mycophenolic acid 32.932 µM 1.19985360058848 0.100637759267401 no 410 0.115098101443097 673 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_810 3825-7150 143 µM 1.19978813503837 0.100650279296335 no 411 0.115110816672762 660 22330411 YGL099W LSG1
SGTC_39 0986-0283 58.349 µM 1.1989357104689 0.100813405860558 no 412 0.11527647239841 695 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_699 0375-0592 111 µM 1.19740970219153 0.101105915951909 no 413 0.115573451932612 643 762578
SGTC_2373 9071805 200 µM 1.19731928486548 0.101123266821724 no 414 0.115591065271576 623 10149009
SGTC_457 grayanotoxin iii 135 µM 1.19659381422328 0.101262561476062 no 415 0.115732456340748 682 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_266 formosanin C 406 nM 1.19594843118395 0.101386596297512 no 416 0.115858341892496 643 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2682 pyrogallin 40.03 µM 1.19536855933481 0.101498135020669 no 417 0.115971532023899 673 822798 An ATP competetive kinase inhibitor.
SGTC_1607 st000305 50.6 µM 1.1931200872071 0.101931475201602 no 418 0.116411172817331 625 5457690
SGTC_1962 st076595 64.5 µM 1.19189924279046 0.102167327546449 no 419 0.116650377568718 624 279619
SGTC_393 acivicin 6.25 µM 1.18815323469909 0.102893488351446 no 420 0.117386522140636 566 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1394 3474-0001 65.7 µM 1.18772231858033 0.102977260999678 no 421 0.117471413884274 553 5017666 YIL048W NEO1
SGTC_2084 5306078 60.6385 µM 1.1860208049924 0.103308529398755 no 422 0.117807041729885 613 679340
SGTC_1872 amphotericin b 148 nM 1.18374533714502 0.103752749422718 no 423 0.118256943182833 635 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1368 1852-0141 284 µM 1.18223563835033 0.104048238605425 no 424 0.118556107714109 604 2838987
SGTC_115 0527-0192 112.043 µM 1.18185510667595 0.104122815213004 no 425 0.118631598850894 736 4233931
SGTC_694 1315-0438 43.2 µM 1.17952221529241 0.104580862464421 no 426 0.119095147997676 544 6793154
SGTC_2674 ligustilide 100 µM 1.17834059782824 0.104813421079383 no 427 0.119330424486327 593 5319022 A signalling regulator.
SGTC_1626 st003712 1.76 µM 1.17486915897415 0.105498813705431 no 428 0.120023533006864 602 24207035
SGTC_1917 st066507 28.5 µM 1.17328406386227 0.105812846782565 no 429 0.120340955367082 671 3156428
SGTC_2486 5283202 22.39 µM 1.1715603160444 0.10615511551517 no 430 0.120686814229796 608 1377751
SGTC_1966 st070145 16.1 µM 1.16948380415351 0.106568490510467 no 431 0.121104381382505 639 3748532
SGTC_607 4491-0986 66.8 µM 1.16799172292104 0.106866238449167 no 432 0.121405051811746 669 698981 YDR232W HEM1
SGTC_349 k015-0014 24 µM 1.16754140201719 0.106956218727548 no 433 0.121495899336216 600 2196908
SGTC_485 niflumic acid 177 µM 1.16073717561864 0.108322453043673 no 434 0.122874399345836 617 4488 A COX2 inhibitor.
SGTC_2497 7-hydroxyflavone 100 µM 1.15925489485305 0.108621741888257 no 435 0.123176150696458 587 5281894
SGTC_3287 9117173 37.0625 µM 1.15439672697049 0.109606827698719 no 436 0.124168778216477 602 2789709
SGTC_105 0111-0055 734.78 µM 1.15328723772437 0.109832694655683 no 437 0.124396253337315 567 5179370
SGTC_346 4513-0042 7.16 µM 1.15317835415633 0.109854878879111 no 438 0.124418593088463 667 2827372
SGTC_644 1498-1197 63.3 µM 1.15233835438082 0.110026130742294 no 439 0.124591030991521 697 6741615
SGTC_317 4495-0002 170 µM 1.15222263485323 0.110049737637947 no 440 0.124614799361292 604 15991618
SGTC_2094 5332512 191.667 µM 1.14738929756661 0.111038990828346 no 441 0.125610381229072 687 755774
SGTC_743 1275-0778 158 µM 1.14732140333027 0.111052932152235 no 442 0.125624405654222 710 2849257 YMR203W TOM40
SGTC_1856 st057054 55.7 µM 1.14640354178523 0.111241527818238 no 443 0.125814108953569 698 1266018
SGTC_1413 3910-0535 34.4 µM 1.14410739693149 0.111714327375064 no 444 0.126289550210729 696 2876951
SGTC_2468 5987765 72.9 µM 1.14367772191109 0.111802961256776 no 445 0.126378657891248 700 26772094
SGTC_431 k089-0097 107 µM 1.1435058032461 0.111838438930803 no 446 0.126414323322038 730 5499420
SGTC_245 methotrexate 289.6 µM 1.14312952982034 0.111916115986759 no 447 0.126492407691397 718 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3214 9129694 49.47 µM 1.14265529566297 0.112014070782197 no 448 0.126590868751266 635 17158655
SGTC_167 3672-0051 66.205 µM 1.14113362982804 0.112328790258566 no 449 0.126907159212291 619 3237971
SGTC_2473 5854593 8.94 µM 1.14090089552148 0.112376981330711 no 450 0.126955583367234 646 2872951
SGTC_19 0279-0214 38.434 µM 1.14077794461134 0.112402446093324 no 451 0.126981170493557 763 3566274 YBR002C RER2
SGTC_2710 st078562 53.7235 µM 1.13979875225561 0.112605396975395 no 452 0.127185076844633 662 17250908
SGTC_3142 9086498 49.47 µM 1.13793464777136 0.112992480968979 no 453 0.12757388609992 636 25236367
SGTC_1839 st053978 48 µM 1.1373749178355 0.11310889487596 no 454 0.127690794027149 655 3788398
SGTC_2046 4110841 106 µM 1.1372622982329 0.113132328096113 no 455 0.127714325303623 673 44119630 YMR134W ERG29
SGTC_1106 tegaserod maleate 11.7 µM 1.13706205505372 0.11317400206632 no 456 0.127756172511742 704 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_798 1287-0182 476 µM 1.13686722894071 0.11321455916542 no 457 0.127796896796894 745 1649755
SGTC_844 0330-0132 15.3 µM 1.13581749815896 0.11343326086609 no 458 0.128016476111301 697 2828079
SGTC_509 pifithrin 175 µM 1.13531075048134 0.113538944820528 no 459 0.128122569712229 696 4817 A p53 inhibitor.
SGTC_3075 9116269 49.47 µM 1.13451654747971 0.113704719771567 no 460 0.128288968305954 668 17015205 YNL244C SUI1
SGTC_1621 st003705 32.4 µM 1.13320567603109 0.113978716823186 no 461 0.128563945564996 741 24207032
SGTC_38 0929-0051 58.268 µM 1.13310646793894 0.11399947233181 no 462 0.128584772762611 714 1379719
SGTC_2525 harmine 47.85 µM 1.13106934738066 0.114426257546143 no 463 0.129012952304864 628 5280953 A monoamine oxidase inhibitor
SGTC_153 4077-0274 519.67 µM 1.12781667487228 0.115110061834103 no 464 0.129698674840083 639 3121976
SGTC_2806 7952793 58.44 µM 1.12219782019387 0.116298140145718 no 465 0.13088916963172 689 2972490
SGTC_131 0141-0277 33.849 µM 1.11831691670018 0.117123801272812 no 466 0.131715832210735 688 1547771
SGTC_277 nystatin 15.5 µM 1.11687349389968 0.117431946118792 no 467 0.132024209649683 706 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2346 9031566 143.75 µM 1.11650436277878 0.117510841075891 no 468 0.132103151878881 694 4771086
SGTC_204 PMA1.184 62.41 µM 1.11616807644625 0.117582748726747 no 469 0.132175098262349 742 2252213 YGL008C PMA1
SGTC_198 3454-2873 16.191 µM 1.10835626852664 0.119261909688667 no 470 0.133853991726983 689 710957
SGTC_2237 6667747 47.222 µM 1.10272867346111 0.12048201172752 no 471 0.135072505465713 668 729940 YDL015C TSC13
SGTC_2953 9074162 66.49 µM 1.10122021594178 0.120810544593586 no 472 0.135400412634411 647 16451992
SGTC_2746 daunorubicin 9.88 µM 1.10055765606026 0.120955045215736 no 473 0.135544611619547 563 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_530 4358-1714 28 µM 1.09621945687427 0.12190418754341 no 474 0.136491373414518 760 1564641
SGTC_3347 9188721 44.724 µM 1.08743289918194 0.123842573248206 no 475 0.138422769113823 684 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_516 3992-2719 87.3 µM 1.0874165723366 0.123846195050984 no 476 0.13842637521036 661 5350887 YDR037W KRS1
SGTC_2776 terbinafine 19.92 µM 1.08668276067103 0.124009053889638 no 477 0.138588517680073 679 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_451 chloral hydrate 100 µM 1.08348443383614 0.124720625883722 no 478 0.139296728221117 775 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2194 5927483 104.545 µM 1.07806793831886 0.12593220040886 no 479 0.140501719238982 755 760979
SGTC_1734 st037168 69.4 µM 1.0750081582651 0.126620235540921 no 480 0.141185537894247 720 708907
SGTC_554 4483-2211 187 µM 1.07340489366081 0.126981795880942 no 481 0.141544744907268 723 747107
SGTC_609 0986-0026 86.3 µM 1.07320956010419 0.127025895601359 no 482 0.141588551131342 746 2848610
SGTC_1214 0358-0031 63.7 µM 1.07192468887362 0.127316241784765 no 483 0.141876930002805 711 4301366
SGTC_803 4488-1585 147 µM 1.06864928100885 0.128058482755027 no 484 0.142613866773689 741 747204
SGTC_1756 st041558 35.5 µM 1.0673693859291 0.128349335270132 no 485 0.14290253351914 816 3955792
SGTC_1334 1486-0610 236 µM 1.06586299347224 0.128692245846326 no 486 0.14324278990234 751 3742339
SGTC_754 3474-0146 171 µM 1.0620403346751 0.129565275754887 no 487 0.144108687327721 682 24762078
SGTC_2395 5646831 180.19 µM 1.06129116825591 0.129736852252644 no 488 0.144278799070774 752 6808628
SGTC_2063 5246145 200 µM 1.05847276696142 0.130383740705547 no 489 0.144919980014966 762 711240
SGTC_2437 5741531 144.16 µM 1.0583861242007 0.130403662514233 no 490 0.144939721425511 777 2262990
SGTC_748 act1.228 77.9 µM 1.05662594547901 0.130808837095857 no 491 0.145341167255216 767 4421505 YNR035C ARC35
SGTC_2818 7996756 12.99 µM 1.05519342492738 0.13113922982744 no 492 0.145668435331487 671 2241621
SGTC_687 k029-0044 34.9 µM 1.05384625798084 0.131450462352716 no 493 0.14597665555396 806 5829338
SGTC_2556 citropten 84.59 µM 1.05243842341029 0.131776255262356 no 494 0.146299223925399 802 2775 A potential DNA crosslinker.
SGTC_2183 6420625 130.508 µM 1.05190879444852 0.131898963018053 no 495 0.146420698321106 804 2897619
SGTC_234 nsc-17383 10.7 µM 1.05122219242897 0.13205815656293 no 496 0.146578276435192 806 408974
SGTC_3300 9124615 50.48 µM 1.05073770710469 0.132170567619873 no 497 0.146689536365786 738 24824903
SGTC_2069 5228469 200 µM 1.04965746824275 0.132421443841663 no 498 0.14693781246976 720 2835210
SGTC_3343 9148379 18.9835 µM 1.04769901158999 0.132877114977714 no 499 0.14738865155361 771 1955036
SGTC_590 k048-0076 22.4 µM 1.04732242816762 0.132964857683118 no 500 0.147475447655305 742 6832814
SGTC_3237 9133362 49.47 µM 1.04696438275205 0.133048318076647 no 501 0.147558002813077 750 43845137
SGTC_1261 0712-0010 12.7 µM 1.04626864162449 0.133210598444145 no 502 0.14771850957225 787 2840123
SGTC_611 3453-1652 23.7 µM 1.04572657984573 0.133337127741962 no 503 0.147843643670092 782 1560575
SGTC_1047 2043-3044 82 µM 1.04311828269534 0.133947118374248 no 504 0.148446757070641 778 669592
SGTC_252 miconazole 1.30953 nM 1.03927584002498 0.134849221761294 no 505 0.149338233870859 741 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_406 estrone 100 µM 1.03585073299096 0.13565685194348 no 506 0.150135892496472 772 5870 A steroid.
SGTC_2507 purpurin 79.67 µM 1.03268876533352 0.136405370470344 no 507 0.150874786388921 770 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1175 0741-0056 27.6 µM 1.03044674256837 0.136937823363988 no 508 0.151400170283034 841 765927
SGTC_671 0560-0003 407 µM 1.03030062026772 0.136972574853014 no 509 0.151434453997754 746 3238678
SGTC_1461 k072-0203 53.8 µM 1.02848658676521 0.1374044986177 no 510 0.151860498573567 734 5418714
SGTC_298 1391-0729 10 µM 1.0274938811354 0.13764125643796 no 511 0.152093982604176 757 3237558
SGTC_2836 9010338 19.48 µM 1.02636387316204 0.137911099202729 no 512 0.152360050088772 706 2994051
SGTC_2743 auranofin 4.32 µM 1.02403256583801 0.138468948573968 no 513 0.152909946686381 748 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_859 0439-0102 54.6 µM 1.02380588876238 0.138523271151165 no 514 0.152963484200423 854 610143
SGTC_547 1120-0019 610 nM 1.02321587874329 0.138664733614007 no 515 0.153102893432193 770 3676939
SGTC_486 niguldipine 82 µM 1.01989607361554 0.139462533825752 no 516 0.153888875945357 739 1236 A calcium channel blocker.
SGTC_342 k048-0088 23.3 µM 1.0197421396808 0.139499602105837 no 517 0.153925385334958 764 6820570
SGTC_2398 5228213 48.84 µM 1.01818912769249 0.139873952207797 no 518 0.154294042651799 875 80771 YMR134W ERG29
SGTC_1084 voriconazole 435 nM 1.01808337403573 0.139899468699878 no 519 0.154319167897631 802 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_549 1661-1316 519 µM 1.01650184626791 0.140281440889271 no 520 0.154695234380383 823 2857282
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.01488633065633 0.140672352518228 no 521 0.155080007429786 749 279621
SGTC_1432 4049-0298 68.4 µM 1.01351400889634 0.141004997930154 no 522 0.155407354104484 776 741646
SGTC_586 0957-0265 8.15 µM 1.01289839481557 0.141154393573217 no 523 0.15555434760012 704 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_175 3793-3120 23.7 µM 1.01071195043958 0.141685861555113 no 524 0.156077157829785 745 5322297
SGTC_2667 digitoxin 100 µM 1.00820147270402 0.142297763325438 no 525 0.156678875526159 746 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2763 lisinopril 49.32 µM 1.00772162903898 0.142414923256304 no 526 0.156794059264257 751 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1672 st016598 6.51 µM 1.00735632580922 0.142504160419105 no 527 0.156881785573567 773 4665860 YNL267W PIK1
SGTC_2403 6032726 181.2 µM 1.00687939826629 0.142620722347008 no 528 0.156996366671441 751 2881040
SGTC_1913 st060213 96.1 µM 1.00414991321646 0.14328905335685 no 529 0.15765318000106 827 688959
SGTC_3303 9125618 40.5795 µM 1.0039981852775 0.143326266817604 no 530 0.157689744147706 861 22695467
SGTC_106 0092-0003 11.579 µM 1.0033933832737 0.143474668066062 no 531 0.157835547671977 739 1072148
SGTC_1939 st074455 53.6 µM 1.00100437379204 0.144061877088207 no 532 0.158412346923295 817 1644229
SGTC_3083 9117465 49.47 µM 1.00095469988429 0.144074103911836 no 533 0.158424354781075 787 16420915
SGTC_1224 0823-0416 294 µM 0.99938182646851 0.144461615649295 no 534 0.158804880061914 816 3598164
SGTC_136 0097-0015 404.482 µM 0.998596979109502 0.144655242373283 no 535 0.158994982068536 872 4861337
SGTC_2793 7325131 81.82 µM 0.998243654645857 0.144742466753146 no 536 0.159080611298589 769 4176441
SGTC_2833 9001315 45.46 µM 0.99814298418429 0.144767325516057 no 537 0.159105014612546 798 2989378
SGTC_2249 haloperidol 116.36 µM 0.997610435303122 0.144898876733796 no 538 0.159234149460559 915 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1289 0976-0073 69.1 µM 0.99505282453874 0.14553178373685 no 539 0.15985528661175 849 3391136
SGTC_3044 9093193 49.47 µM 0.994613217445203 0.145640755966925 no 540 0.159962208275903 807 25236277
SGTC_2894 9048625 32.47 µM 0.991037801191957 0.146529087202436 no 541 0.160833561206189 804 4092861
SGTC_229 benomyl 22.8748 µM 0.989707950677466 0.146860421634803 no 542 0.161158443865373 804 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1148 3909-7663 27.7 µM 0.988988143723526 0.147039972185738 no 543 0.161334471279258 839 4084526
SGTC_2079 5212404 121 µM 0.988886539759403 0.147065328397646 no 544 0.161359328430443 830 758462
SGTC_1843 st055809 45.5 µM 0.988739193160488 0.147102105317112 no 545 0.161395380838225 758 16413835
SGTC_3288 9119690 36.221 µM 0.988577443855202 0.147142484173991 no 546 0.161434963313224 735 17595618 YKL019W RAM2
SGTC_22 0964-0034 14.468 µM 0.987663717517853 0.147370725007604 no 547 0.161658684693483 843 138402
SGTC_335 4077-0256 27.6 µM 0.985630423795345 0.147879474957543 no 548 0.162157251463243 908 3121989
SGTC_1833 st055984 71 µM 0.985589295124296 0.147889777870671 no 549 0.162167346597389 800 676288
SGTC_2491 paeonol 100 µM 0.985201791781598 0.147986872756489 no 550 0.162262480343296 790 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1039 k821-0043 94 µM 0.984808349848226 0.14808549929182 no 551 0.162359109204258 839 15992768
SGTC_2798 7813637 45.45 µM 0.982844614866006 0.148578418521137 no 552 0.162841960017171 813 956368
SGTC_1635 st007035 42.4 µM 0.982188076309117 0.148743461378794 no 553 0.163003600350843 933 3716403
SGTC_3072 9116419 49.47 µM 0.981388962460932 0.148944510570018 no 554 0.163200483527589 728 17170162
SGTC_3009 9080819 71.4286 µM 0.9813539098689 0.14895333361247 no 555 0.163209123212229 819 17027216
SGTC_1556 plumbagin 1.48 µM 0.979145418067085 0.149509934330046 no 556 0.163754066579454 770 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_183 3914-0051 30.55 µM 0.978783340765811 0.149601320049072 no 557 0.163843521388146 841 1596232
SGTC_2027 5150920 200 µM 0.975910006006016 0.15032785054037 no 558 0.164554531579005 814 786715
SGTC_424 splitomicin 100 mM 0.975768640394676 0.150363655799384 no 559 0.164589564204945 752 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2872 9044037 25.97 µM 0.974148500317128 0.150774412632148 no 560 0.164991405509762 801 6465195
SGTC_2781 5567276 71.43 µM 0.973754909061819 0.150874313168456 no 561 0.165089123282384 785 2853274
SGTC_300 r073-0011 5.04 µM 0.97153299946664 0.15143910007686 no 562 0.165641464281708 914 2735780
SGTC_127 0180-0333 59.125 µM 0.969743599630861 0.151894968084314 no 563 0.166087156072073 894 771601
SGTC_1884 5633444 25 µM 0.96215597102844 0.153838114363528 no 564 0.167985631044546 848 5724239
SGTC_2795 7780010 54.55 µM 0.959861864114444 0.154428846476709 no 565 0.168562370885576 795 953673
SGTC_3030 9087619 49.47 µM 0.957405680281035 0.155062973526601 no 566 0.169181266256398 860 25236973
SGTC_274 sirtinol 40.1 µM 0.957379031882788 0.155069862911052 no 567 0.169187988960371 842 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2825 7998094 58.44 µM 0.95715557740476 0.155127640332384 no 568 0.169244367514257 805 2987815
SGTC_1067 clotrimazole 1.36 µM 0.95569964841182 0.155504439993847 no 569 0.169612000099177 865 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1397 3532-0190 20.1 µM 0.955168648739146 0.155642014761036 no 570 0.169746208747292 780 5322280
SGTC_3272 9137413 49.47 µM 0.951342289025434 0.156635745103114 no 571 0.170715323065539 815 17614870
SGTC_376 3970-0862 59.1 µM 0.949228563875489 0.157186480113373 no 572 0.17125218845766 875 3135186
SGTC_2145 5634607 200 µM 0.948856029737108 0.157283676398653 no 573 0.171346920235384 801 308662
SGTC_1400 3771-8998 51.5 µM 0.94659454328361 0.15787455895772 no 574 0.171922712782521 817 670767
SGTC_1440 4100-1550 40 µM 0.945357772911976 0.158198318870873 no 575 0.172238126364443 863 742806
SGTC_1795 st049545 62.3 µM 0.942771121617159 0.158876856248617 no 576 0.172898992947193 866 5291882
SGTC_1372 2752-0194 270 µM 0.942674962487535 0.158902117690413 no 577 0.172923591866692 801 823334
SGTC_1013 4112-3890 241 µM 0.942432651079483 0.158965785675524 no 578 0.172985588577753 837 705171
SGTC_1736 st036774 51 µM 0.940292731491045 0.159528780973701 no 579 0.173533713443732 893 1272247
SGTC_848 0368-0089 85.6 µM 0.938033599177901 0.160124554642785 no 580 0.174113571766409 884 762535
SGTC_1086 cerivastatin 2.18 µM 0.937562659864968 0.160248932768157 no 581 0.17423460413735 851 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1545 lovastatin 49.4 µM 0.937360393179007 0.16030237209122 no 582 0.174286603500112 920 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_41 0478-0632 82.643 µM 0.937035306789878 0.160388285061573 no 583 0.174370198400741 948 3750424
SGTC_166 k072-0058 166.424 µM 0.934667405259658 0.161014975365317 no 584 0.174979864829266 901 5846229
SGTC_921 1561-0023 372 µM 0.932225680331668 0.16166287517088 no 585 0.175609953285926 881 24050882
SGTC_1722 st034304 3.6505 µM 0.92858021011414 0.162633340839807 no 586 0.176553340871686 860 4036148 YLR033W RSC58
SGTC_280 3448-3607 3.04 µM 0.924986525278688 0.163593722453285 no 587 0.177486458303054 904 626179
SGTC_1954 st077032 68.9 µM 0.924287911872779 0.163780847572552 no 588 0.177668217368299 775 698907
SGTC_2376 9072922 81.32 µM 0.922710659902596 0.164203828624564 no 589 0.178079004576329 898 17087968
SGTC_2988 9073640 71.4286 µM 0.920600291354401 0.164770885800448 no 590 0.178629575019196 832 9102229
SGTC_1922 5578187 25 µM 0.918635777596754 0.165299890391502 no 591 0.179143055912243 857 1350412
SGTC_2037 5169046 200 µM 0.918248071440581 0.165404421679994 no 592 0.179244503410358 873 5718022
SGTC_584 0986-0246 15.4 µM 0.916513103443365 0.165872718359823 no 593 0.179698918976194 982 53315 YDR232W HEM1
SGTC_581 0958-0271 211 µM 0.915296109450745 0.166201716142158 no 594 0.180018100502702 955 4591145
SGTC_3192 9110362 49.47 µM 0.914683686188513 0.166367435761669 no 595 0.180178855565281 922 16649480
SGTC_865 0488-0499 301 µM 0.91283308350135 0.166868850553566 no 596 0.180665167807921 958 9634651
SGTC_377 3970-0964 33.1 µM 0.911847085673911 0.167136401110159 no 597 0.180924609866384 978 16481235
SGTC_665 3914-0008 307 µM 0.911050535925093 0.167352746775471 no 598 0.181134373550145 864 1069549
SGTC_3187 9109394 49.47 µM 0.910931278231784 0.167385153102964 no 599 0.181165792018749 879 17098090
SGTC_350 k064-0020 19.8 µM 0.910725798122599 0.167440998446967 no 600 0.181219933811153 947 2790705
SGTC_3043 9092303 49.47 µM 0.908753742821879 0.167977573641213 no 601 0.181740064337148 849 25236084
SGTC_3199 9111318 49.47 µM 0.908298438680024 0.168101614119797 no 602 0.181860283601183 874 8548020
SGTC_1291 0993-0025 5.79 µM 0.908040281864637 0.168171971075276 no 603 0.181928469847984 923 4353356
SGTC_1960 st011366 51.8 µM 0.907524049797924 0.168312719570163 no 604 0.182064868742494 930 3972846
SGTC_2308 7584454 197.62 µM 0.907084559605979 0.168432604407814 no 605 0.182181041261048 934 893577
SGTC_3231 9132313 49.47 µM 0.906332617376735 0.168637847721667 no 606 0.182379913127182 898 4905967
SGTC_2882 9058044 58.44 µM 0.903296436656341 0.169468210199153 no 607 0.183184293610801 898 18076804
SGTC_3056 9094900 49.47 µM 0.902063935155652 0.169806033405175 no 608 0.183511452783647 898 25236784
SGTC_1152 3909-8331 15.9 µM 0.901409325826986 0.169985634391315 no 609 0.183685362379647 868 16001939
SGTC_1689 st020265 53.493 µM 0.899909449893895 0.170397604732984 no 610 0.184084220376138 926 5758320 YPR016C TIF6
SGTC_2869 9037858 32.47 µM 0.899678546538683 0.170461083622802 no 611 0.184145671743908 923 27187042
SGTC_2891 9063876 19.48 µM 0.898513302707912 0.170781658115918 no 612 0.184455978193425 874 6472478
SGTC_1280 0880-0253 10.1 µM 0.8982628428064 0.170850613402315 no 613 0.184522718544628 911 6836607
SGTC_3117 9124945 49.47 µM 0.89672104968901 0.171275483991572 no 614 0.184933892728906 825 17592065
SGTC_2176 5809774 33.9695 µM 0.894449384806849 0.171902714439179 no 615 0.185540749774428 952 2870539
SGTC_2948 9070189 9.45 µM 0.893649984298841 0.172123785721366 no 616 0.185754596842419 831 6473636 YDL196W YDL196W
SGTC_605 1315-0399 119 µM 0.890661052337482 0.172951970581312 no 617 0.186555517634123 965 24020461
SGTC_2291 7917025 104.35 µM 0.890114561347776 0.173103668524913 no 618 0.186702187472182 874 2964612
SGTC_2972 9093619 59.92 µM 0.889410229184856 0.173299305843368 no 619 0.186891324727421 870 25236256
SGTC_925 2064-1272 59.6 µM 0.888605592124869 0.173522976343505 no 620 0.18710754231426 860 6815817
SGTC_1992 st073643 23.3 µM 0.887051526091372 0.173955490591203 no 621 0.18752558004481 909 3161292
SGTC_2008 4012253 172 µM 0.879827865134942 0.175974905413354 no 622 0.189476283441251 947 603940
SGTC_540 1187-0821 17.3 µM 0.879765026660347 0.175992537134907 no 623 0.189493307168855 912 847520
SGTC_2598 perillyl alcohol 100 µM 0.8796680736563 0.17601974317809 no 624 0.189519574794823 937 10819 An apoptosis inducer.
SGTC_3207 9114163 49.47 µM 0.877665172656946 0.17658237409919 no 625 0.190062724954916 983 849233
SGTC_2127 5253358 187.912 µM 0.875583859173991 0.177168235275311 no 626 0.190628151622285 842 20612
SGTC_1001 4048-4355 44.4 µM 0.875419727082568 0.177214488375734 no 627 0.190672784971095 915 21824233
SGTC_75 0159-0059 199.013 µM 0.87444118106015 0.177490404933616 no 628 0.190939019505097 917 5377270
SGTC_87 0100-0052 35.5 µM 0.874416724250407 0.177497304390193 no 629 0.190945676426757 1098 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_621 3584-0052 32.1 µM 0.873898069679319 0.177643660746462 no 630 0.191086883014883 978 2273927
SGTC_1893 st059353 36.1 µM 0.873490585406691 0.177758699951611 no 631 0.191197867776963 907 3112488
SGTC_919 tnp00227 403.569 nM 0.87280495131865 0.177952371256187 no 632 0.191384700191388 958 1269246 A methoxyflavone. YNL221C POP1
SGTC_474 dl-dihydrosphingosine 5 µM 0.871668066867543 0.178273800532844 no 633 0.191694742898382 970 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1293 1000-1278 195 µM 0.87134569951475 0.178365009409769 no 634 0.191782712479401 959 678847
SGTC_2850 9015429 58.44 µM 0.870942368633848 0.178479167067472 no 635 0.191892810687745 907 6457570
SGTC_2164 5685496 200 µM 0.870639648003866 0.178564878505864 no 636 0.191975470483876 958 759046
SGTC_708 3448-5400 146 µM 0.869716376981201 0.17882645084538 no 637 0.192227710075242 947 3462195
SGTC_822 1487-0950 154 µM 0.868722717652422 0.179108234252243 no 638 0.19249940628503 956 1958375
SGTC_2393 9031399 185.94 µM 0.867492883809018 0.179457378954711 no 639 0.192836004583604 962 1526623 YDL150W RPC53
SGTC_2681 menadione 3.18 µM 0.867129771249889 0.179560546853084 no 640 0.192935455066648 945 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3143 9086658 49.47 µM 0.866979642645911 0.179603212429795 no 641 0.192976581942471 983 25236626
SGTC_1498 4478-3555 97.6 µM 0.86618275238565 0.179829790127426 no 642 0.193194975108555 926 3437919
SGTC_1325 1431-0015 227 µM 0.862921316792227 0.18075897544288 no 643 0.194090364759859 894 1103340
SGTC_780 0109-0199 192 µM 0.861782185365213 0.181084222764344 no 644 0.194403694941046 999 610414
SGTC_333 3486-0131 40.1 µM 0.860213115955083 0.181532826833874 no 645 0.194835787988745 995 6744690
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.860181811275215 0.181541784055477 no 646 0.194844414664474 1001 3256 An antibiotic and ribosome inhibitor.
SGTC_3177 9107506 49.47 µM 0.860069759949982 0.181573847616723 no 647 0.194875294713428 934 8897194
SGTC_1704 st028805 70.8 µM 0.859882918378708 0.181627320338097 no 648 0.194926792707651 944 2876101
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.85981434440888 0.181646948189612 no 649 0.194945695405335 965 115019
SGTC_1810 st050138 53 µM 0.859499702368655 0.181737024848409 no 650 0.195032442070761 948 3444541
SGTC_119 0121-0043 24.815 µM 0.857172150505687 0.182404231021853 no 651 0.195674875640268 1102 1092378
SGTC_207 4185-0010 4.486 µM 0.856776739449241 0.18251772976498 no 652 0.195784141581492 1040 3761753
SGTC_2472 5377652 49.4 µM 0.855052535425168 0.183013160460359 no 653 0.196261032264258 960 1610903
SGTC_2247 cerulenin 830 nM 0.853976189493596 0.183322861380072 no 654 0.196559091201444 963 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2200 6600604 21.907 µM 0.850065892132248 0.184450733188782 no 655 0.197644226618769 983 2904777
SGTC_3017 9080681 49.47 µM 0.844742536208741 0.18599310354432 no 656 0.19912730230834 949 16451914
SGTC_3179 9107801 49.47 µM 0.844603080386054 0.186033616170804 no 657 0.199166244304376 997 4818259
SGTC_2546 rhodinyl acetate 100 µM 0.841748794494184 0.186864002222972 no 658 0.199964289716535 1006 6708682
SGTC_2725 haloperidol 53.21 µM 0.841460862972462 0.186947896172944 no 659 0.200044900691171 992 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_542 3381-0244 89.3 µM 0.839560952584184 0.18750205276741 no 660 0.200577300181695 1034 1112843
SGTC_1882 5615643 20 µM 0.839120355479503 0.187630708842032 no 661 0.200700887255746 957 2253075
SGTC_2809 7964133 12.99 µM 0.838969740517157 0.18767470150494 no 662 0.200743145092937 963 1253665
SGTC_2717 st081029 62.2815 µM 0.837342644496411 0.188150361153799 no 663 0.201199997626427 972 5292846
SGTC_1955 wogonin 32.4 µM 0.835106225728511 0.188805360950154 no 664 0.20182895082781 972 5281703 A flavanone.
SGTC_2964 9083345 53.42 µM 0.834180548436806 0.189076882956764 no 665 0.202089625285688 944 17741579
SGTC_727 3032-0951 202 µM 0.833280863313587 0.189341011208864 no 666 0.202343173208699 949 3652836
SGTC_2827 7993847 71.43 µM 0.833276024244547 0.189342432469527 no 667 0.202344537462126 916 2985692
SGTC_2616 abietic acid 100 µM 0.830583319592469 0.190134312599867 no 668 0.203104530519809 1036 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1399 3562-5772 25 µM 0.829391762573358 0.190485378495196 no 669 0.203441380591254 918 23847490
SGTC_3210 9128157 49.47 µM 0.828927282324624 0.190622335062955 no 670 0.203572778178364 884 17590849
SGTC_2246 7293507 91.5585 µM 0.828645036198672 0.190705587624985 no 671 0.203652647969207 1037 887656
SGTC_2657 nystatin 74.44 µM 0.828542593642746 0.190735810051754 no 672 0.203681641705683 1036 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2532 xanthone 78.9 µM 0.827796652687638 0.190955964882851 no 673 0.203892835347336 912 7020 An insecticide.
SGTC_2659 sanguinarine 24.21 µM 0.827345097318472 0.191089311319256 no 674 0.204020744809485 955 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_476 mead acid 10 µM 0.826875939249298 0.191227916383093 no 675 0.204153691111882 986 5312531 An omega 9 fatty acid.
SGTC_811 0416-0114 265 µM 0.824609509821964 0.191898363440917 no 676 0.204796660302317 976 6612453
SGTC_1264 0783-0040 158 µM 0.82436501462168 0.191970775021949 no 677 0.204866093667701 945 2855798
SGTC_1454 4239-0054 42.6 µM 0.824361218256598 0.191971899514497 no 678 0.204867171894937 1051 1340767
SGTC_3058 9093861 49.47 µM 0.82418474836347 0.192024174774034 no 679 0.204917295836804 990 17217477
SGTC_2879 9041815 71.43 µM 0.821936534454434 0.192690920066902 no 680 0.205556509232302 951 4942971
SGTC_552 k242-0005 476 µM 0.820984875090493 0.192973576144761 no 681 0.205827441747797 984 4088318
SGTC_2973 9094665 17.96 µM 0.819485946940676 0.193419291846168 no 682 0.206254608277413 1052 25237061 YIL048W NEO1
SGTC_2563 tomatine 8.54 µM 0.819006376182664 0.19356202774066 no 683 0.206391387864479 1009 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_343 4130-2827 29.8 µM 0.8187389932951 0.1936416374937 no 684 0.206467672145063 1003 1118244
SGTC_788 1182-0090 188 µM 0.817607709474949 0.193978683327728 no 685 0.206790611975871 1098 5715185
SGTC_1813 st051246 8.6015 µM 0.815821539351472 0.194511568087796 no 686 0.207301106057612 986 5291959
SGTC_2557 derrustone 83.84 µM 0.815066500879562 0.194737093404875 no 687 0.207517122750802 1054 629853 An antioxidant.
SGTC_2352 9027995 87.8 µM 0.81316348014453 0.195306219217771 no 688 0.208062167320308 948 2997347
SGTC_1865 st057639 52.2 µM 0.811921590561898 0.195678168560256 no 689 0.208418312378522 1057 688818
SGTC_2903 5923464 63.88 µM 0.811120785375745 0.195918239801271 no 690 0.208648155234976 1051 2876576
SGTC_1378 2093-0007 380 nM 0.810885615495725 0.195988774681506 no 691 0.208715680816872 992 3618014
SGTC_1985 st071382 65.5 µM 0.809804818904156 0.196313137786046 no 692 0.209026181281447 1098 6123237
SGTC_1553 gossypol 38.6 µM 0.808689885513902 0.196648086637865 no 693 0.209346773751488 970 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_292 k038-0015 474 µM 0.808257140122499 0.196778185431552 no 694 0.209471285029479 1045 46368540
SGTC_1649 st011737 51.3 µM 0.807521116946274 0.196999580093021 no 695 0.20968315667478 997 1761035
SGTC_3126 9127922 49.47 µM 0.8066116282906 0.197273361072681 no 696 0.209945136085231 1043 45595682
SGTC_2415 st077333 57.7 µM 0.806359098415512 0.197349420284429 no 697 0.210017911755818 1092 2766255
SGTC_2019 4016004 108 µM 0.805138825935009 0.197717202746609 no 698 0.210369786477337 1007 45595336
SGTC_3283 9109332 35.8195 µM 0.804448370473466 0.197925485050299 no 699 0.210569037721316 929 17027281
SGTC_729 4092-0585 94.1 µM 0.803521665855901 0.198205242328749 no 700 0.210836639605911 1017 2169061
SGTC_1591 genipin 88.4 µM 0.803233601758995 0.198292252873922 no 701 0.210919863680865 983 442424 A DNA cross-linking agent.
SGTC_628 1636-0253 16 µM 0.802892782567875 0.198395228006861 no 702 0.211018354006368 1040 4456143
SGTC_1713 st033146 12.748 µM 0.800768717269596 0.199037720134875 no 703 0.211632776166356 1030 674619
SGTC_1403 3909-7815 62.9 µM 0.798235225749252 0.199805693720723 no 704 0.212366999570027 1010 6615483
SGTC_2862 9027634 71.43 µM 0.797325490624585 0.200081894738566 no 705 0.212631009889065 991 5012562
SGTC_329 k048-0121 21.3 µM 0.796865119374826 0.200221753617304 no 706 0.21276468525651 1019 6832902
SGTC_1688 st021091 57.6 µM 0.796402195147546 0.200362447302462 no 707 0.21289915137448 1075 3656366
SGTC_1925 st057770 10.1 µM 0.795253454313854 0.200711833428616 no 708 0.213233041568195 987 5989122
SGTC_1780 st038448 24.544 µM 0.794115469503369 0.201058308488839 no 709 0.213564106331893 1030 728868 YDL195W SEC31
SGTC_1929 genistein trimethyl ether 50.5 µM 0.793069821896773 0.201376986268287 no 710 0.213868572050414 1086 136420
SGTC_1396 3511-0007 98.6 µM 0.79214988652176 0.201657601424847 no 711 0.214136642464792 972 X1396
SGTC_1988 st071872 53.4 µM 0.791515763221633 0.201851169368723 no 712 0.214321540639118 1066 16414116
SGTC_1719 st032227 49.2 µM 0.790936231762084 0.202028170253466 no 713 0.214490602065857 1090 3125804
SGTC_2770 toltrazuril 17.5 µM 0.789636168332512 0.202425574268434 no 714 0.21487013965293 1069 68591 Kills coccidiodes.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.788078559269131 0.202902319953155 no 715 0.215325377822341 1075 6710655
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.786918280556938 0.203257888099669 no 716 0.215664852748537 1055 2724 A muscle relaxant with antifungal properties.
SGTC_1885 st057546 99.9 µM 0.786825309891983 0.203286395102616 no 717 0.215692067573722 1087 702008
SGTC_50 0929-0078 56.389 µM 0.786590516869676 0.203358398812797 no 718 0.215760806191644 975 1377751
SGTC_290 2043-6722 48.1 µM 0.78610386490857 0.203507688268073 no 719 0.215903320117379 1060 773758 YLR208W SEC13
SGTC_2588 indole-3-carbinol 100 µM 0.786008265940395 0.203537022693304 no 720 0.215931322271063 1059 3712 Induces cell cycle arrest.
SGTC_881 0833-0569 170 µM 0.78593689091747 0.203558925675159 no 721 0.215952230295066 1005 5418700
SGTC_2995 9067767 71.4286 µM 0.783539202497618 0.204295525136198 no 722 0.216655271053227 1010 11673567
SGTC_3049 9092223 49.47 µM 0.783045775945562 0.204447308530932 no 723 0.216800115721966 1010 8623917
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.782612704401198 0.204580581357592 no 724 0.216927289387558 1081 6312947
SGTC_2300 7976697 71.57 µM 0.782111455324135 0.204734899565191 no 725 0.217074537556597 955 2236109
SGTC_448 monastrol 171 µM 0.782022125086474 0.204762408693048 no 726 0.217100785490374 1079 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1947 st076332 61.6 µM 0.780952876230008 0.205091853067045 no 727 0.217415105551287 1066 24208416
SGTC_397 arbidol 50 µM 0.780600634780029 0.205200450500888 no 728 0.217518709160968 1091 131410 A RNA synthesis inhibitor.
SGTC_513 4245-1575 41.7 µM 0.779115624014034 0.205658660717724 no 729 0.21795580364435 1111 719745
SGTC_3020 9089140 49.47 µM 0.777486389709829 0.206162070088991 no 730 0.218435930631733 1098 17217859
SGTC_715 0868-0130 184 µM 0.776556576216917 0.206449695888814 no 731 0.218710214690666 1080 2876258
SGTC_2719 novobiocin 32.65 µM 0.776412845361846 0.206494178379503 no 732 0.218752631286723 1055 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2283 7944793 200 µM 0.77579873292271 0.206684300687597 no 733 0.218933916109254 1099 2970533
SGTC_839 0122-0028 230 µM 0.77428267440898 0.207154098943908 no 734 0.21938182352299 1083 759448
SGTC_1793 st048256 72.231 µM 0.773853255332321 0.207287282612786 no 735 0.219508787597348 1046 672022
SGTC_3304 9125678 46.087 µM 0.771861404831634 0.207905713794775 no 736 0.220098259207352 1029 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_702 1488-0190 94 µM 0.770503654388095 0.208327892860515 no 737 0.220500594061441 1087 949357
SGTC_617 3770-0098 35 µM 0.770375014151889 0.208367918478943 no 738 0.220538735172249 1044 5962639
SGTC_1242 0402-0103 60.1 µM 0.769876138445613 0.208523183485563 no 739 0.220686684781839 1052 432868
SGTC_1453 4237-0541 195 µM 0.769794619683603 0.208548561039617 no 740 0.220710865883711 1091 739892
SGTC_2218 6965428 192.983 µM 0.769138923914392 0.208752751493752 no 741 0.220905421646082 1080 675684
SGTC_1130 3454-2858 15.9 µM 0.765975233259622 0.209739611869156 no 742 0.221845519448348 1014 715628 YIL048W NEO1
SGTC_1350 1495-0454 146 µM 0.76496011189025 0.210056842338984 no 743 0.222147648584823 1115 1069057
SGTC_1530 rhein 70.4 µM 0.76457586039838 0.210176996349672 no 744 0.222262074054693 1146 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.764420758789863 0.21022550747881 no 745 0.222308270972173 1058 4620898
SGTC_3312 9133330 71.43 µM 0.763633051560089 0.210471980147585 no 746 0.222542973620135 1125 17617324
SGTC_868 0527-0199 213 µM 0.763280738424444 0.210582273387764 no 747 0.22264799339027 1055 2849450
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.762202405876074 0.21092006102199 no 748 0.222969605208197 1135 688751
SGTC_900 1112-0045 141 µM 0.762131969527459 0.210942136253985 no 749 0.222990621995235 993 56211 YIL048W NEO1
SGTC_524 r073-0010 27.8 µM 0.761085239061476 0.2112703483308 no 750 0.223303078213464 1025 2772106
SGTC_411 enrofloxacin 100 µM 0.76044317093026 0.211471822727733 no 751 0.223494863182832 1148 71188 A bacterial gyrase inhibitor.
SGTC_1915 st067105 30.6 µM 0.760150921529364 0.21156356484092 no 752 0.223582188743961 1119 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_734 2023-0417 80 µM 0.759404600205586 0.211797953644132 no 753 0.223805281263316 1065 3935732
SGTC_2638 epoxomicin 18 µM 0.759288123950752 0.211834547743019 no 754 0.223840110091809 1087 9915668 A protesome inhibitor.
SGTC_3262 9137218 49.47 µM 0.759101111253995 0.211893310469704 no 755 0.223896037230241 975 17650664
SGTC_1645 Cervolide 78 µM 0.758861497687839 0.211968615262868 no 756 0.223967706541507 1047 23173 A fragrance.
SGTC_2775 cyproheptadine 69.59 µM 0.758776366004385 0.211995373876034 no 757 0.223993172883432 1132 2913 A selective serotonin reuptake inhibitor.
SGTC_2572 astragaloside iv 100 µM 0.758331319731226 0.212135293094584 no 758 0.224126331065239 1070 45006101 An anti-inflammatory agent.
SGTC_2199 6590217 200 µM 0.757694958566359 0.2123354540519 no 759 0.224316808887937 1055 703109
SGTC_3144 9087057 49.47 µM 0.757174093967963 0.212499368843464 no 760 0.224472784248747 1036 17249618
SGTC_751 0833-0568 350 µM 0.757112496885993 0.212518758178112 no 761 0.224491233854108 1118 6954252
SGTC_1267 0828-0272 9.49 µM 0.757044242918835 0.212540244152972 no 762 0.22451167833978 1120 745334
SGTC_1900 st060200 72.8 µM 0.756849324104004 0.212601610513134 no 763 0.224570069259136 1110 688945
SGTC_42 0133-0086 60.653 µM 0.755466511342307 0.213037258958536 no 764 0.224984559309896 1086 162923 Model of phenazepam hydroxylation.
SGTC_661 1304-0007 33.6 µM 0.755043905459654 0.213170502724403 no 765 0.225111319403584 1085 3117130
SGTC_1855 st056195 39.6 µM 0.754291466103896 0.213407860238383 no 766 0.225337112753864 1071 4028379
SGTC_1375 2910-0797 186 µM 0.752079762252384 0.21410643504436 no 767 0.226001546763482 1082 742508
SGTC_68 0986-0284 82.829 µM 0.749719187627842 0.21485349730944 no 768 0.226711924397939 993 423278 YIL048W NEO1
SGTC_269 exalamide 29 µM 0.746327384327543 0.215929564032621 no 769 0.227734836502956 1060 3316 A derivative of salicylamide.
SGTC_2983 9022671 12.99 µM 0.746136587069798 0.215990188052738 no 770 0.22779245489162 1075 6405161
SGTC_99 0109-0120 622.8 µM 0.745457248549281 0.216206121469709 no 771 0.227997673234127 1116 759414
SGTC_2605 digitonin 300 nM 0.74501419943004 0.21634701564762 no 772 0.228131567973413 1188 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1053 3366-3204 134 µM 0.744712434576315 0.216443010394804 no 773 0.228222790226333 1101 3632071 YPR165W RHO1
SGTC_1834 st055981 52.8 µM 0.744273125813135 0.216582803437833 no 774 0.228355628076423 1126 471719 YDL150W RPC53
SGTC_1037 k284-1091 78.7 µM 0.73998383126311 0.217950447737109 no 775 0.229654902615641 1111 3334711
SGTC_3113 9123498 49.47 µM 0.73915296116519 0.21821594575234 no 776 0.229907060195723 1180 8897275
SGTC_851 0394-0702 453 µM 0.738466154618659 0.218435550018359 no 777 0.23011561343176 1158 762646
SGTC_1837 st055472 66.5 µM 0.736761254071033 0.218981236489432 no 778 0.230633774678695 1171 676091
SGTC_114 0364-0001 490.298 µM 0.736687728344293 0.219004787446488 no 779 0.230656135611105 1148 4003655
SGTC_1659 st012954 42.1 µM 0.736375711415407 0.219104745504676 no 780 0.230751040898864 1099 24207262
SGTC_2756 carbadox 75.1 µM 0.734840474389528 0.21959695751373 no 781 0.231218327067552 1125 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_905 2-aminofluorene 215 µM 0.731484620069352 0.220675085559016 no 782 0.232241597667787 1196 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.729774520953251 0.221225649502375 no 783 0.232764010549194 1167 688664
SGTC_2890 9046729 58.44 µM 0.7290904512136 0.221446104598282 no 784 0.232973167609147 1077 903329
SGTC_2698 st077697 67.5 µM 0.729028231961937 0.221466162220709 no 785 0.232992196571807 1093 3154499
SGTC_212 3807-4682 38.772 µM 0.728829435534145 0.221530255192587 no 786 0.233053001702323 1243 3125501 YBL034C STU1
SGTC_270 tamoxifen 5.46 µM 0.728319007541323 0.221694868305377 no 787 0.233209164781249 1222 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_100 0086-0128 49.5915 µM 0.728010506894386 0.221794393691899 no 788 0.233303577278308 1135 93297
SGTC_256 clotrimazole 625 nM 0.726260022340632 0.222359600520224 no 789 0.233839691091487 1121 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1942 st076330 65.2 µM 0.726247455971756 0.222363660991978 no 790 0.233843542208844 1193 24208414
SGTC_2055 5235184 200 µM 0.725004557592718 0.222765477873946 no 791 0.234224617213754 1129 2836034
SGTC_651 3253-0966 34.4 µM 0.724218518682468 0.223019810004219 no 792 0.234465795589806 1181 781462
SGTC_557 1315-0110 16.2 µM 0.723141191883879 0.223368660257404 no 793 0.234796572196268 1175 6833801
SGTC_3181 9108277 49.47 µM 0.722041014470532 0.223725230024449 no 794 0.235134630785756 1138 17097298
SGTC_1953 st076800 12.1 µM 0.722027268832914 0.223729687059784 no 795 0.235138856195875 1100 297591
SGTC_2137 5261020 140 µM 0.721140204418067 0.22401742521799 no 796 0.235411628530263 1161 763655
SGTC_1319 1306-0155 43.7 µM 0.720970679122121 0.224072438261591 no 797 0.235463777433249 1194 3122360
SGTC_2000 st075254 36.4 µM 0.720797270275315 0.224128719504105 no 798 0.235517127578289 1113 17234175
SGTC_569 4130-2812 160 µM 0.718366175230565 0.224918595858517 no 799 0.23626576852427 1071 743552
SGTC_2661 dactinomycin 12.96 µM 0.718095148252421 0.225006751692409 no 800 0.236349310749035 1168 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2814 7977482 42.97 µM 0.71727302800495 0.225274279125328 no 801 0.236602823190043 1193 6456762
SGTC_2049 5262831 67.185 µM 0.716942696741251 0.225381823449351 no 802 0.236704727639254 1185 763417
SGTC_1980 st071811 45.7 µM 0.716889145964622 0.225399260449931 no 803 0.236721249882478 1184 4974850
SGTC_1194 1488-0194 225 µM 0.714160838618408 0.226288651660461 no 804 0.237563864741673 1154 1391452
SGTC_3151 9099821 49.47 µM 0.714073855146303 0.226317039665634 no 805 0.237590755906804 1145 17174189
SGTC_3134 9127454 49.47 µM 0.710286293735694 0.227555100907261 no 806 0.238763308795256 1253 24262820
SGTC_1999 st074831 12.5 µM 0.710189642560738 0.227586743637029 no 807 0.238793271422403 1146 17112523
SGTC_458 nppb 133 µM 0.708501694263995 0.228139762109451 no 808 0.239316880208446 1181 4549 A chloride channel blocker.
SGTC_1940 st075990 51.1 µM 0.707923000425834 0.228329531977177 no 809 0.239496537779526 1265 1084979
SGTC_791 1348-1292 225 µM 0.706885629195429 0.228669936925074 no 810 0.239818777628617 1193 5437054
SGTC_1710 st031758 61.5 µM 0.706864675006908 0.228676815806944 no 811 0.239825289089143 1174 5394341
SGTC_312 4092-0653 6.84 µM 0.706333397955165 0.228851263289588 no 812 0.239990414293693 1192 1148278
SGTC_1287 0971-0001 34.6 µM 0.705173205419131 0.229232477861869 no 813 0.240351226935879 1179 4665869
SGTC_366 0181-0206 4.31 µM 0.704827960236991 0.229345986787542 no 814 0.240458653059683 1187 274874
SGTC_2908 7930301 100 µM 0.704096541917097 0.229586564889964 no 815 0.240686326762765 1159 2223178
SGTC_2813 7971799 71.43 µM 0.70276851635579 0.230023740218936 no 816 0.241100010327826 1179 2234054
SGTC_2161 5662504 8.5105 µM 0.702053080752622 0.230259448810527 no 817 0.241323030579811 1154 2859334
SGTC_2184 6075246 200 µM 0.701191868568096 0.230543364282708 no 818 0.241591641869909 1188 2267320
SGTC_1245 0418-0076 17.2 µM 0.700955168191199 0.230621431462118 no 819 0.241665496930754 1171 6790114
SGTC_3330 9141424 71.43 µM 0.699963434828369 0.230948679892269 no 820 0.241975069987858 1189 27261020
SGTC_3322 9139058 2.11 µM 0.699344279448832 0.23115311782576 no 821 0.242168450527755 1205 4908926 YPR165W RHO1
SGTC_1830 st055982 50.3 µM 0.698724844923248 0.231357748940497 no 822 0.242362002062299 1147 455313 An antimicrobial agent.
SGTC_2099 5377090 177.372 µM 0.698529910267154 0.23142216678699 no 823 0.242422929631291 1175 2243829
SGTC_786 4544-0069 423 µM 0.698389334892615 0.231468627343956 no 824 0.242466872148938 1180 748821 YLR208W SEC13
SGTC_1521 st012942 49.4 µM 0.698352949613004 0.231480653628459 no 825 0.242478246542238 1229 24207259
SGTC_1398 3558-0053 112 µM 0.697619800260795 0.231723052840115 no 826 0.242707497755025 1120 4532369
SGTC_2981 9013952 38.96 µM 0.69732805659209 0.231819550593813 no 827 0.242798756798524 1127 2996344
SGTC_894 0960-0238 55.9 µM 0.697175347185566 0.231870070004358 no 828 0.242846532554328 1182 6741907 YDL195W SEC31
SGTC_519 k048-0011 62.8 µM 0.693345907752583 0.233138930309902 no 829 0.244046249813185 1181 6836379
SGTC_1355 1499-0035 1.68 µM 0.693120431362497 0.233213760448518 no 830 0.244116988371618 1209 1548538
SGTC_3013 9080133 71.4286 µM 0.691176443223049 0.233859475560192 no 831 0.244727332863798 1267 17050193
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.689967323519682 0.234261595964166 no 832 0.245107368309989 1212 5282362
SGTC_1345 1488-0192 31.4 µM 0.688961397667033 0.234596431071795 no 833 0.245423780111721 1223 658348
SGTC_2655 perillic acid 100 µM 0.688455636091693 0.234764880137166 no 834 0.245582949204518 1193 5702197 An apoptosis inducer.
SGTC_736 0958-0254 92.6 µM 0.687719534862145 0.235010165616407 no 835 0.245814707927112 1242 6812352
SGTC_2203 7227154 166.4 µM 0.684920096126653 0.235944293449382 no 836 0.24669717199699 1209 896304
SGTC_1673 st016611 27.3 µM 0.683097218097594 0.236553657028835 no 837 0.247272706590863 1228 5226799
SGTC_3105 9121040 49.47 µM 0.680421874898456 0.237449554237202 no 838 0.248118687012788 1086 41448907
SGTC_3247 9135149 49.47 µM 0.680141609575334 0.237543514878936 no 839 0.248207400025002 1190 8934436 YOR116C RPO31
SGTC_941 3237-0776 460 µM 0.67853920835306 0.238081121230208 no 840 0.24871493633781 1222 760008
SGTC_1825 st052143 62.6 µM 0.677914894219809 0.23829075928253 no 841 0.248912827887509 1235 674173
SGTC_1236 0330-0013 258 µM 0.677132058137268 0.238553770139868 no 842 0.249161085198165 1213 4617066
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.677047017383823 0.238582351001176 no 843 0.249188061720361 1237 91467 include heat shock
SGTC_595 3909-8003 73.7 µM 0.676624527782395 0.238724370900281 no 844 0.249322106372013 1260 699517
SGTC_1140 3229-1848 2.98 µM 0.675800428494077 0.239001524968172 no 845 0.249583681309904 1231 2849525
SGTC_118 0083-0097 135.343 µM 0.67507046533863 0.239247166823172 no 846 0.249815498478394 1305 5207356
SGTC_1263 0774-1208 64.8 µM 0.672609688884972 0.240076264673663 no 847 0.250597818048884 1268 906585
SGTC_1775 st081588 35.1725 µM 0.671283243092761 0.240523826717976 no 848 0.251020053756718 1263 1426443 YGL099W LSG1
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.670924559129887 0.240644929879497 no 849 0.251134295060972 1272 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1886 st057356 49.9 µM 0.670500536295953 0.240788136331592 no 850 0.251269382343835 1198 24207747
SGTC_359 0081-0058 15.9 µM 0.670206197353532 0.240887571530301 no 851 0.251363176881013 1323 3494159
SGTC_3219 9131112 49.47 µM 0.669768288126416 0.241035549760468 no 852 0.251502756007379 1182 17612988 YMR079W SEC14
SGTC_1259 0671-0132 43 µM 0.669745233140276 0.241043341867938 no 853 0.251510105685153 1189 X1259
SGTC_3290 9121031 71.43 µM 0.664621403418863 0.242778483498854 no 854 0.253146337986582 1224 17014854
SGTC_1359 1582-0056 520 nM 0.6641808952855 0.242927972791176 no 855 0.253287269764367 1277 3661189
SGTC_3311 9131146 2.8755 µM 0.664143123042032 0.242940793364741 no 856 0.253299356159038 1238 4900406 YPR165W RHO1
SGTC_1002 4049-0206 172 µM 0.66253600086631 0.243486618278837 no 857 0.253813885256938 1270 4662749
SGTC_2476 5806916 10.51 µM 0.66158781766673 0.243808959021218 no 858 0.254117708529465 1181 2870194
SGTC_2712 st079126 47.7 µM 0.66013302174348 0.244303973346527 no 859 0.254584234682423 1224 3152970
SGTC_2580 diallyl disulphide 81.36 µM 0.657022925541719 0.245364040838635 no 860 0.255583087764278 1271 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.656815792239289 0.245434729340136 no 861 0.255649684296193 1295 1377
SGTC_347 4534-1311 26.2 µM 0.656649782698042 0.245491391410978 no 862 0.255703065449704 1264 2862016
SGTC_2857 9024691 58.44 µM 0.654977655847468 0.246062510379541 no 863 0.256241070120307 1281 16478292
SGTC_1482 3346-2049 8.48 µM 0.654758525302499 0.246137407733838 no 864 0.25631161880296 1264 3826804
SGTC_2407 paclitaxel 400 µM 0.654755644103324 0.246138392589873 no 865 0.256312546467253 1363 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_591 4299-0174 154 µM 0.653737886591566 0.246486416257206 no 866 0.256640344936077 1235 5509088
SGTC_466 geldanamycin 89.2 µM 0.653355670372809 0.24661718372092 no 867 0.256763505171385 1171 5288382 HSP90 inhibitor.
SGTC_213 1246-0773 967 nM 0.65331911643891 0.246629691848474 no 868 0.256775285433195 1246 6251622
SGTC_3096 9117468 49.47 µM 0.652461969166079 0.246923090278521 no 869 0.257051599507624 1172 41316311
SGTC_2263 7948595 193.29 µM 0.651663155179461 0.247196689501997 no 870 0.257309248140838 1257 2971371
SGTC_3166 9102297 49.47 µM 0.648746851345367 0.248196918180354 no 871 0.258251007959332 1228 25237072
SGTC_1868 st057644 42.7 µM 0.648553858861137 0.248263186456484 no 872 0.258313393845753 1270 688665
SGTC_2748 diazoxide 86.69 µM 0.647839262261975 0.248508641260315 no 873 0.258544459121685 1239 3019 A potassium channel activatior.
SGTC_1651 st011928 86.1 µM 0.64778628415833 0.24852684370939 no 874 0.258561593887044 1274 720198
SGTC_316 k060-0003 58.6 µM 0.646667435117449 0.24891142863177 no 875 0.258923601747805 1291 6152314
SGTC_2913 7966556 36.57 µM 0.646138960999299 0.249093192509858 no 876 0.259094682682121 1233 2976516
SGTC_2292 7671323 168.05 µM 0.644905203586324 0.249517806864927 no 877 0.259494309697145 1265 937504
SGTC_1932 st074806 40.9 µM 0.644530727957077 0.249646763775328 no 878 0.259615669239139 1365 17251235
SGTC_1696 st025591 34.7925 µM 0.644230240147237 0.249750267343976 no 879 0.259713072096578 1287 2787147
SGTC_1738 st035555 74 µM 0.644201695359183 0.249760100832744 no 880 0.259722325845189 1280 5331140
SGTC_2702 st077768 96.8 µM 0.643255929689865 0.250086027002948 no 881 0.260029023641044 1211 6484119
SGTC_1407 3909-7909 12.3 µM 0.642098143023254 0.250485326013815 no 882 0.260404730783297 1278 4411780
SGTC_1123 mangostin 811.285 nM 0.64188301099976 0.25055955823549 no 883 0.260474572913873 1273 5281650 An antioxidant.
SGTC_1910 st062352 60.4 µM 0.641085329587107 0.250834903302363 no 884 0.260733622570123 1213 2245730
SGTC_2009 4012297 12.05 µM 0.639918589846 0.251237928887421 no 885 0.261112763751227 1275 45595307
SGTC_1727 st034309 9.9045 µM 0.639351054124644 0.251434095830414 no 886 0.261297291305616 1342 870305
SGTC_893 0958-0369 48.9 µM 0.638511233941535 0.251724525499543 no 887 0.261570471805158 1305 6819948
SGTC_1045 1348-1485 165 µM 0.637704460878805 0.252003693440013 no 888 0.26183304058233 1299 6810614
SGTC_2140 5586273 200 µM 0.637393354007909 0.252111389478359 no 889 0.261934328147295 1280 854421
SGTC_2118 5526350 200 µM 0.636577906682792 0.252393788507883 no 890 0.26219990995802 1302 743594
SGTC_784 4579-0127 173 µM 0.635127790675674 0.252896392371735 no 891 0.262672536643842 1369 1948547
SGTC_2364 9055074 200 µM 0.634927586806188 0.252965823518367 no 892 0.262737821988352 1257 6470630
SGTC_904 1141-0088 396 µM 0.634927044325157 0.252966011665619 no 893 0.26273799889961 1215 1378119
SGTC_1906 st060206 94.7 µM 0.634870552870577 0.252985604849605 no 894 0.262756421949735 1278 5133468
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.628370833774641 0.255245252376378 no 895 0.264880519475946 1333 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1525 8-methoxypsoralen 92.5 µM 0.627768106228788 0.255455325824138 no 896 0.265077931115898 1345 4114 Related to psoralen; DNA damaging agent.
SGTC_463 ikarugamyin 104 µM 0.624889837945207 0.256459756087666 no 897 0.266021681179772 1346 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_412 gemfibrozil 100 µM 0.624882994860686 0.256462146570666 no 898 0.266023926972424 1285 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2071 5230951 39.92 µM 0.623780418255727 0.256847459338876 no 899 0.266385900645852 1323 1799272
SGTC_1505 k297-0037 20.6 µM 0.622571689976995 0.257270214402986 no 900 0.26678300984708 1292 4089396
SGTC_2426 5582046 32.21 µM 0.621826643793135 0.25753097581714 no 901 0.267027932328766 1330 2251934
SGTC_43 0570-0105 72.5 µM 0.621142857120309 0.257770417547894 no 902 0.267252816571811 1349 1114046 YDL195W SEC31
SGTC_1235 benzylparaben 21.5 µM 0.6208275164412 0.257880879382304 no 903 0.267356558228511 1298 7180
SGTC_1315 1237-0019 3.69 µM 0.620557371898455 0.257975528827264 no 904 0.267445447287953 1305 825140
SGTC_1248 0469-0687 58.6 µM 0.619030185042177 0.25851094177055 no 905 0.267948236946606 1342 4017482
SGTC_1693 xanthone 101.9 µM 0.618449414323393 0.258714703792857 no 906 0.268139566630776 1356 7020 An insecticide.
SGTC_1610 st001799 48.1 µM 0.61758015241267 0.259019837523726 no 907 0.268426065555843 1263 621897
SGTC_2506 ethyl hematommate 54.16 µM 0.616020394318372 0.259567819754483 no 908 0.268940529840784 1275 3940691 An allergen.
SGTC_639 0833-0042 114 µM 0.615020026085584 0.259919589071185 no 909 0.269270747602329 1293 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1519 esterone 74 µM 0.614856645030357 0.259977063708426 no 910 0.269324698380873 1272 698 A steroid.
SGTC_1811 st050069 61.5 µM 0.613968869933788 0.260289482203331 no 911 0.26961794922597 1305 3877702
SGTC_824 1304-0008 100 µM 0.612893983783021 0.26066800600737 no 912 0.269973220769251 1326 768245
SGTC_606 k015-0008 38.6 µM 0.612312455989119 0.260872910486592 no 913 0.270165525042323 1397 1970475
SGTC_2052 5265182 7.135 µM 0.608727472956363 0.262137925890356 no 914 0.271352546934308 1371 1239884
SGTC_3118 9124250 49.47 µM 0.60673119060625 0.262843704362681 no 915 0.272014659643195 1276 1504786
SGTC_182 3448-4371 550.524 µM 0.60509878534817 0.263421556721141 no 916 0.272556680637082 1376 3491403
SGTC_2425 5628681 7.85 µM 0.602303951921594 0.264412398505668 no 917 0.273485915366292 1334 5714958
SGTC_2537 larixol 68.93 µM 0.601728776465256 0.264616548415335 no 918 0.273677345851719 1314 6708759
SGTC_1640 st009078 66.4 µM 0.601223720681062 0.264795876486952 no 919 0.273845493677545 1370 690618
SGTC_2730 imipramine 71.33 µM 0.600500077443453 0.265052925142089 no 920 0.274086504646595 1353 3696 A tricyclic antidepressant.
SGTC_2624 nerol 100 µM 0.600232061069303 0.265148160634289 no 921 0.27417579467633 1325 637566 A natural product oil.
SGTC_1427 4048-4900 550 nM 0.599874174397251 0.265275357244011 no 922 0.274295047519204 1370 24132586
SGTC_3146 9095609 49.47 µM 0.599428179993342 0.265433911593076 no 923 0.274443694925216 1398 17173999
SGTC_1025 k007-0731 70 µM 0.599386398333596 0.265448767748982 no 924 0.274457622551899 1308 6256118
SGTC_834 0312-0008 75.7 µM 0.599267947491524 0.265490887186283 no 925 0.274497109215163 1355 6385573 YIL048W NEO1
SGTC_1150 3909-7983 10.9 µM 0.598808248084913 0.265654381874469 no 926 0.274650380729452 1314 23965914
SGTC_2024 5144227 134 µM 0.59857823925653 0.265736204971525 no 927 0.274727085381407 1350 3475211
SGTC_2411 st077133 39.94 µM 0.597574435684838 0.266093446479605 no 928 0.275061963092107 1483 1403142 YNL221C POP1
SGTC_670 4204-0025 119 µM 0.597559078197016 0.266098913911475 no 929 0.275067088046434 1376 719039
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.596708845921821 0.266401694535287 no 930 0.275350892807349 1457 6728940
SGTC_3069 9117009 49.47 µM 0.593368728575123 0.267592846027728 no 931 0.276467206071801 1258 41904981
SGTC_2694 st077685 81.9 µM 0.593316278258976 0.267611572231019 no 932 0.2764847533731 1307 2838096
SGTC_583 1488-1091 88.9 µM 0.592832287324205 0.267784401452687 no 933 0.276646698747733 1415 4303273
SGTC_2967 9089538 49.85 µM 0.592824333452441 0.267787242185133 no 934 0.276649360534431 1396 728216
SGTC_3235 9132602 49.47 µM 0.592567434790617 0.267879001936751 no 935 0.276735339179705 1375 4912240
SGTC_1959 st077091 55.8 µM 0.591109741085649 0.268399964571921 no 936 0.277223446726226 1353 821356 YKL052C ASK1
SGTC_724 3910-0327 137 µM 0.590303583114035 0.268688294615346 no 937 0.277493568801294 1333 2885483
SGTC_478 N-arachidonylglycine 10 µM 0.590111783657886 0.268756916420039 no 938 0.277557854631568 1311 5283389
SGTC_1840 st055363 71 µM 0.588461282539202 0.269347794553976 no 939 0.278111357155859 1293 676033
SGTC_363 0455-0021 3.06 µM 0.588156064266711 0.269457133784547 no 940 0.278213772350301 1380 4597466
SGTC_1800 st050079 29.0735 µM 0.585475531355258 0.270418343560433 no 941 0.279114007297337 1316 3645560
SGTC_495 decylubiquinone 155 µM 0.585365149045382 0.270457962154313 no 942 0.279151108629023 1310 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1982 st072467 71.9 µM 0.584493513178415 0.270770912930274 no 943 0.279444164136889 1348 3163533
SGTC_2762 leflunomide 42.06 µM 0.582983200866405 0.271313600748442 no 944 0.279952304597679 1382 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_482 fipronil 114 µM 0.582898402424724 0.27134408672381 no 945 0.279980848080675 1379 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2122 5258151 111.688 µM 0.581590931046871 0.271814353071437 no 946 0.280421126500312 1341 2173356
SGTC_1583 clindamycin 39.6 µM 0.580090929622908 0.272354366961426 no 947 0.280926650061931 1299 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_903 1134-0042 114 µM 0.579768651742247 0.272470459388478 no 948 0.281035320124155 1347 701009
SGTC_1239 0337-0584 35.4 µM 0.578839829221521 0.272805181535869 no 949 0.281348626772653 1453 914301 YML130C ERO1
SGTC_2941 9056145 11.23 µM 0.578586371335962 0.272896556215573 no 950 0.281434151429292 1280 2119517
SGTC_663 1486-0733 13.9 µM 0.577498481744874 0.273288926072456 no 951 0.281801381979863 1366 722445 YPR165W RHO1
SGTC_2816 7982706 58.44 µM 0.57721687554189 0.273390538676746 no 952 0.281896479241229 1362 2981853
SGTC_654 1124-0271 80.9 µM 0.576022176729347 0.273821832480575 no 953 0.282300095987967 1351 5403748
SGTC_2646 retinol 96.75 µM 0.575375194168731 0.274055537618069 no 954 0.282518788416518 1377 445354 A vitamin A analog and teratogen.
SGTC_2765 myclobutanil 7.74 µM 0.574780523999327 0.274270433197565 no 955 0.282719870077609 1374 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2013 4024628 200 µM 0.574305076354756 0.27444230524475 no 956 0.282880687309699 1396 5230760
SGTC_2224 6650123 117.647 µM 0.572970251791192 0.274925121848659 no 957 0.283332418134145 1359 2908370
SGTC_3345 9148410 3.559 µM 0.571376588882063 0.275502109959207 no 958 0.283872197538859 1380 4903596
SGTC_422 cantharidin 155 µM 0.56936603847428 0.276230881495618 no 959 0.284553879648111 1322 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.568972074496088 0.276373793823095 no 960 0.28468754565922 1390 688798
SGTC_643 k048-0106 28.4 µM 0.567619949371362 0.276864559372096 no 961 0.285146529056005 1424 6763920
SGTC_3066 9117245 49.47 µM 0.563937036543545 0.278203465010537 no 962 0.2863984916552 1486 17176980
SGTC_1361 1608-0041 5.61 µM 0.563417627596021 0.278392547430877 no 963 0.286575268278006 1352 X1361
SGTC_2299 7976368 114.88 µM 0.563115929568508 0.278502404460619 no 964 0.286677972511755 1474 2979718
SGTC_499 genistein 192 µM 0.562855850026956 0.278597123935501 no 965 0.28676652295963 1423 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2374 9071832 200 µM 0.562516747343855 0.278720646743103 no 966 0.286881998240622 1355 17381698
SGTC_1424 4048-1941 275 µM 0.559079148623171 0.279974342121468 no 967 0.288053852277354 1486 X1424
SGTC_1507 4075-3230 155 µM 0.558703227222236 0.280111606665803 no 968 0.288182138241156 1325 659771
SGTC_3157 9099274 49.47 µM 0.558163122813638 0.280308878329895 no 969 0.288366500039637 1366 17217662
SGTC_2930 9013230 14.89 µM 0.553883094353691 0.281874521818137 no 970 0.289829427810051 1458 2995857
SGTC_807 1315-0151 48 µM 0.553494730677185 0.282016794323017 no 971 0.28996234389219 1453 4011080
SGTC_3271 9137798 49.47 µM 0.553176112391303 0.282133542236997 no 972 0.29007141120167 1405 6498326
SGTC_2108 5365811 200 µM 0.552749813700969 0.282289782719988 no 973 0.290217369024301 1484 780283
SGTC_1518 st038567 90.8 µM 0.550810340017049 0.283001134075159 no 974 0.29088184760869 1379 77966
SGTC_928 2764-0428 58.7 µM 0.5498762302109 0.283344049388828 no 975 0.291202134321604 1469 662578
SGTC_3031 9088762 49.47 µM 0.549472312778739 0.2834923907146 no 976 0.291340680133246 1352 205253
SGTC_2004 4023728 41.89 µM 0.547538538201143 0.284203097294601 no 977 0.292004400793507 1419 360084 YDR527W RBA50
SGTC_4 0960-0234 25.671 µM 0.545850786246818 0.284824080292991 no 978 0.292584254925065 1407 6821112
SGTC_23 0213-0011 39.996 µM 0.545223791859693 0.2850549382831 no 979 0.292799805070747 1476 627608
SGTC_303 1348-1668 34.2 µM 0.544623113062547 0.285276190569327 no 980 0.293006377483089 1428 5380509
SGTC_842 0271-0008 11.1 µM 0.543856680505769 0.285558614853502 no 981 0.293270050462997 1476 1221709
SGTC_2211 7117706 200 µM 0.542375954240163 0.286104627278494 no 982 0.293779770537591 1452 822771
SGTC_2522 biochanin a 4.94 µM 0.540794657930588 0.286688271654798 no 983 0.294324562668112 1457 5280373 A possible chelator.
SGTC_71 0417-1750 47.813 µM 0.540754998199444 0.286702917012483 no 984 0.294338232332554 1555 6811472
SGTC_2154 5570129 200 µM 0.539475133767706 0.28717572961353 no 985 0.294779525182902 1415 673366
SGTC_356 1634-0012 32.5 µM 0.539306037866745 0.287238225287154 no 986 0.294837851673784 1448 735457
SGTC_1752 st044819 83.042 µM 0.537907873449482 0.287755215383839 no 987 0.29532032624026 1348 441209 YML126C ERG13
SGTC_2917 7979103 53.79 µM 0.537451498458282 0.287924061290785 no 988 0.295477889426293 1505 2980565
SGTC_1116 jasmonic acid 1.58368 µM 0.535610019890388 0.288605831311915 no 989 0.296114051164156 1480 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_896 0964-0007 44.5 µM 0.535533112658654 0.288634321187651 no 990 0.296140633393644 1414 6756758
SGTC_2384 9036245 200 µM 0.535397948969188 0.288684395068632 no 991 0.296187354048611 1491 6462766
SGTC_1304 1165-0502 251 µM 0.535151387642733 0.288775748795167 no 992 0.296272589098348 1453 767425
SGTC_55 0767-0285 6.563 µM 0.534767002302465 0.288918195001307 no 993 0.296405491672147 1391 3116166
SGTC_1181 1222-0449 220 µM 0.533784180912743 0.289282560981844 no 994 0.296745429804919 1483 658318
SGTC_89 0302-0250 142.109 µM 0.531914078030849 0.289976468786184 no 995 0.297392753188988 1496 4203518 YLR208W SEC13
SGTC_955 1216-0110 33 µM 0.531581879867263 0.29009981358532 no 996 0.297507808752893 1378 3619719
SGTC_977 1348-1378 135 µM 0.528407499762736 0.291279695525545 no 997 0.298608266635235 1413 X977
SGTC_2724 maprotiline 69.64 µM 0.528326914577291 0.291309677277377 no 998 0.298636227066539 1478 4011 A tricyclic antidepressant.
SGTC_2191 5911152 200 µM 0.527394986070286 0.291656506258689 no 999 0.298959662320558 1453 2875902
SGTC_683 panaxydol 45 µM 0.526237546565143 0.292087529799941 no 1000 0.299361584810307 1440 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1692 fluoroquinolonic acid 71 µM 0.525255022184698 0.292453648491434 no 1001 0.29970295995992 1456 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_304 1310-0298 97 µM 0.524991751195332 0.292551787556303 no 1002 0.299794462621357 1383 1550234
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.524922267265613 0.292577691511152 no 1003 0.299818614617547 1444 6708784 An antioxidant flavonoid
SGTC_447 ml7 120 µM 0.522676285525947 0.293415578057965 no 1004 0.300599771870989 1532 4216 Selective myosin light chain kinase inhibitor.
SGTC_1631 benzylvanillin 81.9 µM 0.521342004831892 0.293913870963415 no 1005 0.301064272196337 1482 75506
SGTC_1685 st024049 53.0905 µM 0.521027841138622 0.294031253652755 no 1006 0.301173688375392 1435 1941139
SGTC_1912 st060209 90.8 µM 0.520939239626668 0.294064362234935 no 1007 0.301204549536286 1400 688787
SGTC_2829 7992743 58.44 µM 0.520331547394906 0.294291490884131 no 1008 0.301416255723731 1509 16462845
SGTC_1118 chelidonine 707.474 nM 0.519823688099282 0.294481368496721 no 1009 0.301593233740676 1545 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1587 estradiol valerate 56.1 µM 0.518611345728228 0.294934865545061 no 1010 0.302015897774943 1473 13791 A steroid.
SGTC_705 1124-0212 310 µM 0.518365008472179 0.295027051461494 no 1011 0.302101811880678 1530 9554485
SGTC_1377 2944-0135 198 µM 0.515498554266755 0.296100728902246 no 1012 0.303102339800064 1522 1894137
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.515478504542232 0.296108245166466 no 1013 0.303109343318588 1460 165521
SGTC_515 4092-1064 102 µM 0.514049104246511 0.296644325887143 no 1014 0.3036088299225 1573 717353
SGTC_1296 1068-0102 11.9 µM 0.513851345715089 0.296718528019616 no 1015 0.303677963172166 1498 767053
SGTC_480 am 92016 50 µM 0.511932766619282 0.297438850026543 no 1016 0.304349032438331 1394 2129 K+ channel blocker.
SGTC_814 3342-0569 96 µM 0.51152039719787 0.297593776506542 no 1017 0.304493354741616 1485 4346283
SGTC_2641 levomentholum 100 µM 0.511067569347341 0.297763945566782 no 1018 0.304651871881283 1445 16666
SGTC_88 0180-0332 8.668 µM 0.510498861373171 0.297977724299908 no 1019 0.304851006044833 1489 3101745
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.510315693157373 0.298046592576514 no 1020 0.304915155051991 1607 1273210
SGTC_1465 k213-0056 144 µM 0.510098513168416 0.298128258124999 no 1021 0.30499122340161 1443 24048857 YMR208W ERG12
SGTC_1522 st012842 45.6 µM 0.509488746868216 0.298357601212904 no 1022 0.305204842059311 1398 3491067 YOR116C RPO31
SGTC_1410 3909-8106 77.9 µM 0.509332369319194 0.298416430305039 no 1023 0.305259636304687 1515 1039210
SGTC_871 0574-0004 149 µM 0.509017996114754 0.298534713189949 no 1024 0.305369804980712 1472 9551173
SGTC_2171 5739187 198.077 µM 0.508779946385983 0.298624293561516 no 1025 0.305453238653625 1403 2262761
SGTC_147 4466-0538 29.23 µM 0.508695213091966 0.298656182453576 no 1026 0.30548293913074 1505 6742687 YHR072W ERG7
SGTC_145 3737-0113 38.366 µM 0.507359310253352 0.299159146370684 no 1027 0.305951365154111 1452 6849351
SGTC_2937 9044753 11.33 µM 0.505672355336803 0.29979482911889 no 1028 0.306543339081509 1426 6465530 YGL099W LSG1
SGTC_3125 9127534 49.47 µM 0.504335828375444 0.300298896515056 no 1029 0.307012702127111 1424 1639235
SGTC_2943 9068529 45.32 µM 0.503606390930722 0.300574163284204 no 1030 0.307269000330606 1450 3270634
SGTC_985 1493-0307 8.71 µM 0.503357096058844 0.300668265449565 no 1031 0.307356615219854 1525 3278274
SGTC_2298 7976326 193.81 µM 0.50327938328211 0.300697602668654 no 1032 0.307383929687767 1412 2235818
SGTC_2324 6149169 200 µM 0.502207344767215 0.301102437878749 no 1033 0.30776083849028 1462 2888231
SGTC_169 k015-0017 16.025 µM 0.501933702549464 0.301205813058344 no 1034 0.30785707853512 1565 1840002
SGTC_2523 spermine 47.74 µM 0.501605545067173 0.30132980381809 no 1035 0.307972509045578 1534 1103 A DNA binding polyamine.
SGTC_746 1095-0025 46.6 µM 0.499379635524077 0.302171445607577 no 1036 0.308755981410674 1568 6749286
SGTC_1169 aniline yellow 25.8 µM 0.49925196197677 0.302219752414509 no 1037 0.308800946209137 1529 6051 A DNA damaging agent.
SGTC_537 1334-0398 209 µM 0.497031561886417 0.3030604208441 no 1038 0.309583397274643 1584 5846986
SGTC_2113 5491891 107.031 µM 0.495566705367621 0.30361560409399 no 1039 0.310100074088955 1466 789979
SGTC_1718 roemerine 11.9335 µM 0.494862665242359 0.303882598026594 no 1040 0.310348533130596 1445 235224 An aporphine alkaloid with mutagenic activity.
SGTC_5 0352-0601 109.883 µM 0.493159651208052 0.304528866542789 no 1041 0.310949892546019 1463 762456
SGTC_155 k072-0202 43.6 µM 0.492869313263204 0.304639106465219 no 1042 0.311052465613272 1441 5857737
SGTC_1193 1488-0126 41.5 µM 0.492560988223571 0.304756195428795 no 1043 0.311161409386142 1488 1384710
SGTC_2286 7945697 125 µM 0.490926523426848 0.305377230674779 no 1044 0.311739208416572 1435 1245733
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.489839170731184 0.305790694509821 no 1045 0.312123855044223 1486 688662
SGTC_1062 mesoridazine 14.2 µM 0.489548332542552 0.30590132719395 no 1046 0.312226772630902 1504 4078 A neuroleptic.
SGTC_488 nitrendipine 139 µM 0.487298469143598 0.306757756385706 no 1047 0.313023416212475 1540 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2238 6671620 73.2395 µM 0.486689265246581 0.306989836782869 no 1048 0.313239276840672 1420 729941
SGTC_2952 9073731 13.78 µM 0.486676630772711 0.306994650791355 no 1049 0.313243754320815 1460 16457353
SGTC_1741 st038134 10.228 µM 0.486570235919497 0.307035190857134 no 1050 0.313281460254988 1619 1272587
SGTC_2337 9009472 200 µM 0.485786461405708 0.307333908341473 no 1051 0.313559287117489 1595 5742383
SGTC_1043 0916-0009 19.3 µM 0.485250958521607 0.307538076387094 no 1052 0.313749169250006 1681 3101130
SGTC_2146 5545642 200 µM 0.484685284924435 0.307753812216114 no 1053 0.313949803108113 1499 825326
SGTC_3277 9138724 49.47 µM 0.484435104977963 0.307849246713508 no 1054 0.314038554811243 1487 15943418
SGTC_231 b-estradiol 524 µM 0.48312830927284 0.308347952645459 no 1055 0.314502317249861 1441 450 A steroid.
SGTC_1333 1482-0047 286 µM 0.482780424764999 0.308480773760327 no 1056 0.314625825697207 1510 3811116
SGTC_1450 4112-4260 37.6 µM 0.480410179818078 0.309386391708764 no 1057 0.315467878607695 1581 1633175
SGTC_2148 5546263 113.568 µM 0.480172002256369 0.309477458236211 no 1058 0.315552546643743 1522 792097
SGTC_2650 prasterone 100 µM 0.479334036080814 0.30979794523954 no 1059 0.315850506182391 1506 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_686 1319-0111 510 µM 0.479318486663271 0.30980389360864 no 1060 0.315856036292991 1595 4562600
SGTC_3238 9133470 49.47 µM 0.478462378265644 0.310131471356778 no 1061 0.316160572632309 1593 3534688
SGTC_1897 st060201 15 µM 0.47629662927326 0.310960837085131 no 1062 0.316931533221757 1472 611878
SGTC_723 4182-0001 115 µM 0.474390894770061 0.311691426417696 no 1063 0.317610592402778 1482 744821 YLR208W SEC13
SGTC_1391 3442-0225 151 µM 0.473685629811102 0.311961987588517 no 1064 0.317862051131153 1517 5227075
SGTC_637 1181-0519 7.26 µM 0.471826195072143 0.312675809758379 no 1065 0.31852542590172 1510 6252091 YGR060W ERG25
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.47146813708525 0.312813346186527 no 1066 0.318653234125136 1544 5379071
SGTC_2469 5655019 90.81 µM 0.471190108250539 0.312920159973515 no 1067 0.318752490954176 1632 2788239
SGTC_3095 9117207 49.47 µM 0.470817479612698 0.31306334197172 no 1068 0.318885540487518 1569 17015229
SGTC_3348 9149464 3.537 µM 0.469427552723083 0.313597667898521 no 1069 0.319382028947922 1504 1951442
SGTC_341 1486-1430 230 µM 0.469352133292971 0.313626672393795 no 1070 0.319408978400641 1460 2054753 YPL210C SRP72
SGTC_3102 9121669 49.47 µM 0.468654584196829 0.313894987554628 no 1071 0.31965827722523 1563 41905072
SGTC_2871 9038510 12.99 µM 0.467908266738046 0.314182170672789 no 1072 0.319925095753951 1654 4945164
SGTC_2855 9016525 58.44 µM 0.467882199465663 0.314192203399751 no 1073 0.319934416839415 1486 43811474
SGTC_2033 5192550 145 µM 0.467869665493174 0.314197027502405 no 1074 0.319938898753828 1500 182073
SGTC_2847 9005661 71.43 µM 0.466354606428831 0.314780380342904 no 1075 0.32048084901154 1492 2991449
SGTC_2561 acetosyringone 100 µM 0.465727838010829 0.315021844310432 no 1076 0.320705161780222 1492 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1300 1094-0077 113 µM 0.465536121907177 0.31509571917587 no 1077 0.320773787716709 1491 5532636
SGTC_3226 9131256 49.47 µM 0.463445819842267 0.315901664503792 no 1078 0.321522421000741 1455 17178073
SGTC_202 3594-0513 34.79 µM 0.462116170990573 0.316414785381929 no 1079 0.321999007124475 1537 708429
SGTC_747 3448-8087 38.7 µM 0.460720887639527 0.316953615342609 no 1080 0.322499433590038 1519 5168703
SGTC_1569 carminic acid 40.6 µM 0.459293804388521 0.317505127637063 no 1081 0.323011598148351 1596 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_988 1497-1057 103 µM 0.459292925936956 0.317505467249449 no 1082 0.323011913518505 1609 3533044
SGTC_787 4152-0075 138 µM 0.457100550231211 0.318353525147149 no 1083 0.323799387408951 1577 9566539
SGTC_484 loperamide 105 µM 0.456646926928777 0.318529115475521 no 1084 0.323962421899488 1540 3955 An opioid-receptor agonist.
SGTC_652 0437-0092 114 µM 0.456091459781387 0.318744183447554 no 1085 0.324162105577195 1501 3091274
SGTC_1048 3161-0300 24.5 µM 0.455837021602212 0.318842718226422 no 1086 0.324253589903998 1501 2165101
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.455474132885017 0.318983274165174 no 1087 0.32438408644008 1577 65057 A dermal irritant. YDR527W RBA50
SGTC_244 nsc-207895 1.295 µM 0.454570312980567 0.319333459507823 no 1088 0.324709198183105 1460 42640
SGTC_250 brefeldin a 552.239 µM 0.454029795663772 0.319542960195588 no 1089 0.324903690733788 1486 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2483 5729050 27.16 µM 0.453212828261202 0.319859720303172 no 1090 0.325197747988561 1679 2865180
SGTC_2723 salbutamol 83.58 µM 0.450615031016501 0.320867828127723 no 1091 0.326133515719031 1579 9884233 β2-adrenoceptor agonist
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.450056595391963 0.321084708994587 no 1092 0.326334816383001 1444 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2965 9082772 38.63 µM 0.449321304432608 0.32137036865778 no 1093 0.32659994568974 1685 16459634
SGTC_24 0417-1663 219 µM 0.449100342642273 0.321456232711355 no 1094 0.326679636643469 1537 4329390
SGTC_1647 st011722 22.4 µM 0.449078976145651 0.321464536073718 no 1095 0.326687342994688 1573 2854783
SGTC_299 1273-0059 1.44 µM 0.448137123035141 0.321830643849647 no 1096 0.327027118858101 1569 2848077
SGTC_134 0269-0018 6.916 µM 0.446139149316488 0.322607848865688 no 1097 0.327748367462327 1497 4378915
SGTC_3195 9113082 49.47 µM 0.445882595506726 0.322707703698938 no 1098 0.327841027477403 1643 17018038
SGTC_2976 9009005 19.48 µM 0.445516659343747 0.322850154012471 no 1099 0.327973211661421 1707 2993148
SGTC_2190 6049624 200 µM 0.442341921400032 0.324087093772274 no 1100 0.329120899810329 1592 2265554
SGTC_2691 st077356 60.2 µM 0.441560588927434 0.324391814829465 no 1101 0.329403604188272 1673 2839272
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.440923804912361 0.324640248745102 no 1102 0.329634079706977 1520 88881 An O-methylated flavonoid and antioxidant.
SGTC_3116 9124943 49.47 µM 0.439758336615603 0.325095144783906 no 1103 0.330056073054003 1480 41905195 YPL160W CDC60
SGTC_2271 7849410 118.62 µM 0.439746822256977 0.325099640276293 no 1104 0.330060243258747 1653 972430
SGTC_1283 0922-0125 16.4 µM 0.438884202353517 0.325436500934831 no 1105 0.330372722031552 1669 3360884
SGTC_856 0433-0016 11.3 µM 0.437494212723574 0.3259796041609 no 1106 0.330876486118268 1572 3911780
SGTC_3222 9128301 49.47 µM 0.436120840360692 0.326516577455799 no 1107 0.331374528694805 1562 4911358
SGTC_3315 9136395 68.55 µM 0.434366582918277 0.327202995628831 no 1108 0.332011130121032 1662 16876844
SGTC_1365 1672-3266 55.4 µM 0.434169485312986 0.327280153951206 no 1109 0.332082685105459 1657 6415873
SGTC_1379 2144-0755 36.5 µM 0.43413736063108 0.327292730585248 no 1110 0.332094348339574 1666 5392327
SGTC_62 0180-0423 3.232 µM 0.432820995833516 0.327808248549986 no 1111 0.332572409456717 1536 30102 YGL099W LSG1
SGTC_1121 fusaric acid 630.51 nM 0.432286031026554 0.328017846646688 no 1112 0.332766769270117 1559 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_669 0108-0021 26.2 µM 0.431774040399074 0.328218494243387 no 1113 0.332952824357986 1839 17201
SGTC_986 1493-0483 84 µM 0.431540817243332 0.328309910137735 no 1114 0.333037590241281 1642 40079
SGTC_91 0417-1751 58.384 µM 0.429830864639383 0.328980469697024 no 1115 0.333659339663184 1595 6795624
SGTC_1728 st035614 33.7865 µM 0.42879160274327 0.329388286496391 no 1116 0.334037445212369 1617 15945546
SGTC_184 1494-0393 24.714 µM 0.427747114899746 0.329798358599002 no 1117 0.334417621876462 1540 3090647
SGTC_870 0573-2213 57.6 µM 0.42763586386936 0.329842048480184 no 1118 0.334458125467761 1539 3916321
SGTC_930 2810-3379 265 µM 0.427502410507727 0.329894460599175 no 1119 0.334506714889542 1725 1015764
SGTC_1642 st009582 77.7 µM 0.426716216812877 0.330203295986241 no 1120 0.334793018681297 1682 6739311
SGTC_1620 st003704 16.5 µM 0.426242663232603 0.330389374836497 no 1121 0.334965516426813 1600 2834414
SGTC_3011 9081274 71.4286 µM 0.426218155813254 0.330399005960362 no 1122 0.334974444505222 1582 6625322
SGTC_3089 9117425 49.47 µM 0.424258689086688 0.331169416144397 no 1123 0.335688581715192 1526 9401657
SGTC_1964 st076914 61 µM 0.422876032447328 0.331713470588816 no 1124 0.336192855213057 1585 24208661
SGTC_1506 4226-2149 212 µM 0.422846972347519 0.33172490911244 no 1125 0.336203456990118 1639 991114
SGTC_1702 st027038 51 µM 0.419728478232449 0.332953308540896 no 1126 0.337341909268753 1605 5521182
SGTC_1637 st007924 17.4 µM 0.418955018196371 0.333258258854284 no 1127 0.337624503398486 1569 683336
SGTC_645 0845-0943 5.41 µM 0.418898115980718 0.333280697916829 no 1128 0.337645297014396 1591 1885106
SGTC_3209 9113616 49.47 µM 0.418210112895508 0.333552055194494 no 1129 0.337896751248043 1799 16649353
SGTC_1560 lithocholic acid 53.1 µM 0.417125477099785 0.333980026392695 no 1130 0.338293315378874 1652 9903 A bile acid which acts as a detergent.
SGTC_3081 9117243 49.47 µM 0.416378137798586 0.334275034236609 no 1131 0.338566661740117 1722 45595589
SGTC_2032 5185112 25.99 µM 0.415002460369064 0.334818342519394 no 1132 0.339070051003355 1613 5718189
SGTC_891 0929-0073 133 µM 0.414303137958123 0.335094664722937 no 1133 0.339326058021791 1665 5603632
SGTC_1662 st014054 52 µM 0.414195622209296 0.335137155178987 no 1134 0.339365423826139 1582 2838777
SGTC_3248 9135562 49.47 µM 0.413868080540001 0.33526661335576 no 1135 0.339485360700524 1612 17650701
SGTC_785 1270-0111 65.3 µM 0.413858374769773 0.335270449780949 no 1136 0.339488914938398 1577 6741994
SGTC_895 0964-0006 13.7 µM 0.413456907328407 0.335429153915929 no 1137 0.339635944192847 1621 6738897
SGTC_688 0527-0193 473 µM 0.412263109004546 0.335901247878949 no 1138 0.340073292577365 1648 4007154
SGTC_3314 9135860 59.4275 µM 0.409030672604063 0.337180830743605 no 1139 0.341258575888137 1727 25252478
SGTC_288 1315-0019 35.1 µM 0.406863209198232 0.338039893808942 no 1140 0.342054229377121 1619 6811474
SGTC_464 bw-b 70c 158 µM 0.405743432755486 0.338484042481723 no 1141 0.342465562978945 1691 5353454
SGTC_1104 tacrolimus 29.8 µM 0.405474443866478 0.338590767870744 no 1142 0.34256439999913 1623 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1447 4239-0816 81.9 µM 0.405157153217854 0.338716674373714 no 1143 0.342680998829351 1559 1341554
SGTC_510 ag-490 170 µM 0.40489067317876 0.338822432261338 no 1144 0.342778937220553 1727 5328779
SGTC_408 cantharidin 100 µM 0.403819096891009 0.339247836772963 no 1145 0.343172876190931 1635 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1466 k213-0079 57.5 µM 0.403803601335969 0.339253989850071 no 1146 0.343178574006541 1614 3657981
SGTC_268 camptothecin 39.6153 µM 0.4027930404298 0.339655362522522 no 1147 0.343550240701623 1625 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2257 7960413 200 µM 0.401040349414802 0.340351924156933 no 1148 0.344195208540492 1704 2974689 YIL048W NEO1
SGTC_1422 4031-0024 15.5 µM 0.39926154942065 0.341059419479334 no 1149 0.344850247831597 1663 782427
SGTC_2596 sinensetin 100 µM 0.39861252782369 0.341317699032502 no 1150 0.345089364614763 1599 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2707 st078556 66.6 µM 0.397141320156224 0.341903444439698 no 1151 0.345631625515639 1752 17250899
SGTC_2368 9071271 200 µM 0.396955917918049 0.341977287377555 no 1152 0.34569998397958 1575 27209959
SGTC_1177 0983-0204 23.6 µM 0.396760167824798 0.342055258271769 no 1153 0.345772163194583 1774 766818
SGTC_1822 st052468 42 µM 0.396258363508997 0.342255166999925 no 1154 0.345957219825927 1608 2873678
SGTC_1513 0337-0559 19 µM 0.395546972832759 0.342538646470152 no 1155 0.346219631288813 1557 775073
SGTC_2011 4012611 177 µM 0.394678739904459 0.342884745638687 no 1156 0.346539997382578 1589 2049887
SGTC_1564 D-Arginine 115 µM 0.394243856928238 0.3430581503674 no 1157 0.346700504546545 1536 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3344 9148862 3.898 µM 0.39405114817953 0.343135001400384 no 1158 0.346771638538822 1711 4905352
SGTC_2363 9053361 176 µM 0.393478253341331 0.343363506553513 no 1159 0.346983141353566 1749 6469797 YMR079W SEC14
SGTC_2951 9072950 58.06 µM 0.393315634236303 0.343428379338919 no 1160 0.347043186191107 1655 16488155
SGTC_2620 irigenin 100 µM 0.393202877963657 0.343473363314719 no 1161 0.347084822127716 1732 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1158 4092-0494 91.8 µM 0.392367152937509 0.343806843861374 no 1162 0.34739347617169 1719 1148199
SGTC_2757 clomiphene 4.22 µM 0.391974673569975 0.343963497428522 no 1163 0.347538463510175 1778 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2788 5282734 71.43 µM 0.391749344322681 0.34405344707877 no 1164 0.347621713349754 1757 743706
SGTC_3260 9137109 49.47 µM 0.391571336982554 0.344124512438598 no 1165 0.347687484897554 1733 17478346
SGTC_2157 5649910 96.377 µM 0.39124005551339 0.344256783644762 no 1166 0.347809901576591 1593 2858091
SGTC_220 paclitaxel 373.376 µM 0.38794861154033 0.345571995769815 no 1167 0.349027031514857 1675 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1090 efavirenz 20.7 µM 0.387492798883622 0.345754279218508 no 1168 0.349195707507486 1693 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2048 5246248 200 µM 0.386376057133056 0.346201025034076 no 1169 0.349609089823761 1738 677046
SGTC_1721 st082152 9.2685 µM 0.38616892729902 0.346283909634071 no 1170 0.349685782334524 1590 5296051
SGTC_2664 lyso-paf C-16 73.48 µM 0.385801683889011 0.346430883012915 no 1171 0.349821774054953 1660 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_634 1611-4317 11.2 µM 0.385410828635723 0.346587331418924 no 1172 0.349966530503382 1732 2843522
SGTC_2006 4011487 200 µM 0.385234798074768 0.346657800068836 no 1173 0.350031731988868 1769 45595294
SGTC_989 1501-0895 10.3 µM 0.384432257290079 0.346979140840184 no 1174 0.35032904803389 1778 2830112
SGTC_2665 lovastatin 100 µM 0.384385842300029 0.346997728970668 no 1175 0.350346246131548 1643 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2935 9038016 29.96 µM 0.383139189521434 0.347497122206127 no 1176 0.35080828177516 1708 6463195
SGTC_1122 capsaicin 818.572 nM 0.382493329828352 0.347755949569379 no 1177 0.35104773775374 1727 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2918 7977171 22.06 µM 0.381530708665542 0.348141850336688 no 1178 0.351404744537624 1637 2236483
SGTC_938 3126-1755 342 µM 0.381012457488034 0.348349674831451 no 1179 0.351597002393544 1727 1777771
SGTC_429 1112-0049 25.5 µM 0.380976020489422 0.348364288187844 no 1180 0.351610521011801 1592 2836170
SGTC_26 0302-0163 425.158 µM 0.375569943853892 0.350534923044019 no 1181 0.353618319460331 1690 3100915
SGTC_2845 9003024 42.97 µM 0.375181019467321 0.350691272392814 no 1182 0.35376292260126 1747 2990173
SGTC_1860 st056228 74.6 µM 0.375165681341784 0.350697438906676 no 1183 0.35376862579053 1624 688679
SGTC_2318 6029776 164 µM 0.372606168357592 0.351727010988886 no 1184 0.354720790628009 1732 818325
SGTC_1782 st039423 80.636 µM 0.371616518184902 0.352125393060746 no 1185 0.35508919439349 1608 2068169
SGTC_306 1672-3436 11.6 µM 0.370904846517293 0.352411975714385 no 1186 0.355354202619096 1709 6797378
SGTC_2566 crystal violet carbinol 226 nM 0.370753028684181 0.352473122001758 no 1187 0.355410744733673 1569 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_604 1000-0114 314 µM 0.370625304188459 0.352524567387991 no 1188 0.355458316136712 1770 1572745
SGTC_730 1436-0052 41.2 µM 0.369965519851124 0.35279036092033 no 1189 0.355704090802905 1682 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2306 7482397 179.52 µM 0.369142847837696 0.353121874269939 no 1190 0.356010626400446 1792 891448
SGTC_2129 girgensonine 121.053 µM 0.369081018475666 0.353146794246938 no 1191 0.356033668386271 1735 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2189 6047310 154.431 µM 0.368252329397266 0.353480853471816 no 1192 0.356342547169425 1667 711535
SGTC_152 4469-0003 551.229 µM 0.366562102097393 0.354162563718071 no 1193 0.356972840697574 1735 697280
SGTC_309 k408-0051 1.48 µM 0.365676604192355 0.354519893627954 no 1194 0.357303202967338 1691 3640463
SGTC_2187 6125751 200 µM 0.365433487371206 0.35461802233779 no 1195 0.357393923915569 1697 874498
SGTC_1219 1469-0211 33.1 µM 0.36495692646671 0.354810403561362 no 1196 0.357571779735255 1793 6822282
SGTC_815 1582-0027 36.9 µM 0.364443330465468 0.35501777681441 no 1197 0.357763491943477 1724 3128206
SGTC_614 0462-0418 107 µM 0.362380015837915 0.355851308084198 no 1198 0.358534035591341 1628 5188303
SGTC_3015 9080845 49.47 µM 0.361861261296905 0.356060981529536 no 1199 0.358727854953784 1791 5296973
SGTC_2896 9052656 71.43 µM 0.359650665030888 0.356954961488181 no 1200 0.359554195042902 1687 6469436
SGTC_2779 methotrexate 400 µM 0.359621834147478 0.356966626094037 no 1201 0.359564976627015 1705 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3293 9120939 62.045 µM 0.358005504963212 0.357620785755099 no 1202 0.360169596933664 1741 934087
SGTC_3339 9145883 14.936 µM 0.357780867694383 0.357711733964517 no 1203 0.36025365473399 1768 2030670
SGTC_805 3852-0218 479 µM 0.357465408114258 0.357839466765915 no 1204 0.360371709055328 1646 6615355
SGTC_426 0988-0037 14.6 µM 0.356219099792663 0.358344265285061 no 1205 0.360838244655663 1847 5383008
SGTC_3291 9121177 71.43 µM 0.355640771506743 0.358578592679134 no 1206 0.361054803015429 1648 17015612
SGTC_264 promethazine 12.5 mM 0.355026785667892 0.358827426100088 no 1207 0.361284762300102 1698 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2448 5185112 27.17 µM 0.35378177087365 0.359332183963064 no 1208 0.361751217931325 1683 5718189
SGTC_2223 6903751 107.57 µM 0.351718357794542 0.360169279924799 no 1209 0.362524745826385 1770 5598863
SGTC_3041 9091929 49.47 µM 0.35053577841432 0.360649337478001 no 1210 0.362968322005049 1747 25236887
SGTC_11 0438-0307 1.3 µM 0.349847470123528 0.360928851287803 no 1211 0.363226585715717 1807 4011476
SGTC_1499 4480-0877 67.3 µM 0.348294085366904 0.361559935180908 no 1212 0.363809667651188 1733 2861909
SGTC_892 0929-0076 29 µM 0.348125964190222 0.361628259344794 no 1213 0.363872792933778 1685 5751038
SGTC_1820 st053765 18.6 µM 0.347685943957987 0.361807103708275 no 1214 0.364038026973504 1660 3690829
SGTC_1740 st038286 13.222 µM 0.344731915533835 0.363008535905888 no 1215 0.36514796107061 1742 716786
SGTC_2101 5377231 179.231 µM 0.343544351397343 0.36349191081214 no 1216 0.365594490554581 1793 2844213
SGTC_2904 7225135 42.03 µM 0.342614785157615 0.363870424430956 no 1217 0.365944138825302 1782 4446116
SGTC_2470 5664817 21.68 µM 0.341252123053102 0.364425532082143 no 1218 0.366456893569929 1723 2859561
SGTC_2734 clemastine 41.6 µM 0.340615050344502 0.364685154043329 no 1219 0.366696698880424 1760 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_386 1509-0011 3.07 µM 0.340131309765895 0.364882331058024 no 1220 0.366878822061226 1709 3107280
SGTC_3258 9138477 49.47 µM 0.339923486905185 0.364967052505506 no 1221 0.36695707436225 1748 4970355
SGTC_2103 5378138 10 µM 0.339557040026742 0.36511645496931 no 1222 0.367095067410171 1763 244142
SGTC_3301 9125354 19.7965 µM 0.338257014242568 0.36564664787202 no 1223 0.367584757046499 1683 41905162
SGTC_3206 9114350 49.47 µM 0.337664331666164 0.36588844843002 no 1224 0.367808078385647 1712 17087243
SGTC_1680 diphenhydramine 100 µM 0.337565167089006 0.365928910452197 no 1225 0.367845447721546 1713 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1249 0481-0015 10.2 µM 0.336215998814503 0.366479558211914 no 1226 0.368353994577016 1685 4227577
SGTC_479 n-linoleoylglycine 10 µM 0.335447833181975 0.366793199247592 no 1227 0.368643645152489 1714 6433346 An anti-infammatory.
SGTC_707 0865-0008 204 µM 0.335097674654788 0.366936198050022 no 1228 0.368775703458764 1785 723043
SGTC_968 1309-0633 340 µM 0.333161025221132 0.36772742581791 no 1229 0.369506368240441 1842 3761976
SGTC_2802 7925815 54.55 µM 0.333004437205141 0.36779142521975 no 1230 0.369565466865966 1680 1262923
SGTC_3037 9091026 49.47 µM 0.331798422349067 0.368284460858435 no 1231 0.370020737823746 1766 25236398 YIL048W NEO1
SGTC_2430 5571206 200 µM 0.33027194404068 0.368908817475181 no 1232 0.370597245027979 1891 1731771
SGTC_1414 3917-0015 5.4 µM 0.329804799942746 0.369099956911874 no 1233 0.370773730147853 1782 6618702
SGTC_2021 4019055 173 µM 0.329146178122392 0.369369497489661 no 1234 0.3710226009519 1756 44827708 YER133W GLC7
SGTC_172 1112-0046 2.638 µM 0.32883088723482 0.369498552833174 no 1235 0.371141757767184 1729 2802135 YIL048W NEO1
SGTC_1907 st060210 83.7 µM 0.328349415895344 0.369695657780595 no 1236 0.371323742431291 1819 688793
SGTC_132 0417-1715 25.805 µM 0.326879171661798 0.370297758751124 no 1237 0.371879637546582 1883 6769098
SGTC_2192 5915882 198.485 µM 0.326279605972694 0.370543386911619 no 1238 0.372106408376212 1756 2876149
SGTC_882 0843-0131 351 µM 0.325768781691166 0.37075270142238 no 1239 0.372299649978026 1818 5425421
SGTC_1681 tripelennamine 100 µM 0.324002635361185 0.371476689059198 no 1240 0.372968019519271 1704 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3029 9088683 49.47 µM 0.3228282019193 0.371958370761837 no 1241 0.373412676778756 1765 25236615
SGTC_600 1495-0418 41.6 µM 0.320649834738003 0.372852335748556 no 1242 0.374237883699016 1751 5377768
SGTC_2861 9024595 19.48 µM 0.320215868013554 0.373030510339316 no 1243 0.374402347536484 1802 16482810
SGTC_2076 5212012 200 µM 0.319815028273795 0.373195108048358 no 1244 0.374554277281965 1751 604802
SGTC_3100 9120536 49.47 µM 0.319405246674051 0.373363401497966 no 1245 0.374709616382821 1857 16421196
SGTC_568 1193-0097 7.48 µM 0.3186010503024 0.3736937475873 no 1246 0.375014528447016 1798 3646150
SGTC_2225 6654152 15.4 µM 0.317379979081154 0.374195514040852 no 1247 0.375477648460971 1804 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2040 5100729 123 µM 0.317218734593253 0.374261789089689 no 1248 0.375538817661067 1794 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_793 0488-0545 106 µM 0.316341368384313 0.374622471068101 no 1249 0.375871707330714 1708 292548
SGTC_1367 1812-0510 76.9 µM 0.314246664025099 0.375484039385526 no 1250 0.376666851822566 1793 1142582 YDR527W RBA50
SGTC_1664 st014217 9.02 µM 0.312955754232008 0.376015310459421 no 1251 0.37715713888425 1819 3982782
SGTC_2490 carminic acid 95.39 µM 0.312742163786974 0.376103235826771 no 1252 0.37723827957758 1768 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1393 3470-5649 58.2 µM 0.311938239583629 0.376434232089589 no 1253 0.377543730229072 1754 4108395
SGTC_3333 9141820 12.094 µM 0.31141898345367 0.376648071512501 no 1254 0.377741062102163 1735 1939433
SGTC_1251 0490-5699 265 µM 0.311207657091535 0.376735110517665 no 1255 0.377821381178164 1905 3883818
SGTC_1065 prochlorperazine maleate 2.48 µM 0.310918537060723 0.37685420055689 no 1256 0.3779312759482 1760 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2400 5203494 178.7 µM 0.310223007025136 0.377140740965289 no 1257 0.378195687961332 1704 6777674
SGTC_845 0330-0138 4.51 µM 0.310015231241282 0.377226352354335 no 1258 0.378274686872302 1862 9039800
SGTC_2159 5658611 73.75 µM 0.30978547581802 0.377321027202249 no 1259 0.378362048637365 1861 793844
SGTC_1766 st045414 44.774 µM 0.308575298564767 0.377819824053234 no 1260 0.378822306670516 1753 253960
SGTC_3035 9091303 49.47 µM 0.307642310012481 0.378204511640057 no 1261 0.379177260898999 1772 25237002
SGTC_193 1273-0060 1.558 µM 0.306951866823365 0.378489271288688 no 1262 0.37944000469377 1860 2847393 YHR072W ERG7
SGTC_980 1473-0395 201 µM 0.306001008623891 0.378881541963985 no 1263 0.379801938910616 1728 768876
SGTC_1797 st048695 56.8 µM 0.304902915359839 0.379334708808085 no 1264 0.380220047645124 1869 592262 YIL048W NEO1
SGTC_475 α-linolenic acid 10 µM 0.304662876967312 0.379433791211507 no 1265 0.380311463052686 1846 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_228 caffeine 993.056 µM 0.303888282080063 0.379753580388173 no 1266 0.380606502715204 1864 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3076 9116187 49.47 µM 0.303461589965952 0.379929774098147 no 1267 0.38076905747615 1904 27241210
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.303448764954274 0.379935070308304 no 1268 0.380773943682701 1732 803109
SGTC_1889 st059080 5.18 µM 0.301867282051483 0.380588330969631 no 1269 0.381376619035172 1909 176925 Isolated from Daphnopsis sellowiana.
SGTC_1879 gemcitabine 100 µM 0.301539998512336 0.380723564070303 no 1270 0.381501377028437 1813 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2207 7258803 200 µM 0.301487949575784 0.380745071961705 no 1271 0.381521218821858 1852 3666799
SGTC_1107 amlodipine 47 µM 0.30098514996141 0.380952860005517 no 1272 0.381712909196357 1746 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2785 7756463 72.73 µM 0.299295002650714 0.381651585272438 no 1273 0.382357483623403 1732 2201551
SGTC_74 000s-0487 160.283 µM 0.299135926460494 0.381717368998347 no 1274 0.382418167606294 1900 677548
SGTC_2311 7694451 200 µM 0.296996557191997 0.382602406331353 no 1275 0.383234568790129 1833 2163142
SGTC_2977 9011197 71.43 µM 0.296562840749399 0.382781905764878 no 1276 0.383400141979231 1849 2704722
SGTC_2874 9043904 71.43 µM 0.29512707815804 0.383376295042096 no 1277 0.383948402555456 1771 4463428
SGTC_2552 juarezic acid 87.02 µM 0.294847932112162 0.383491890238382 no 1278 0.384055024330175 1805 1549512
SGTC_2086 5274770 176.623 µM 0.294155128281011 0.383778827128834 no 1279 0.384319683477105 1777 689278
SGTC_2072 5231554 129 µM 0.292969247168233 0.384270128488531 no 1280 0.384772829022696 1949 789545
SGTC_2412 st077135 33.4 µM 0.292931379704014 0.384285819754173 no 1281 0.384787301428715 1858 13258915
SGTC_1604 st002052 72.4 µM 0.292008003999216 0.384668500612884 no 1282 0.385140252123771 1810 6254834 YHR062C RPP1
SGTC_2212 7123476 200 µM 0.291792796661264 0.384757706615042 no 1283 0.385222526562191 1853 1085715
SGTC_672 1441-0018 53.7 µM 0.291308929411498 0.384958297621584 no 1284 0.385407529387473 1751 251141
SGTC_1571 st070080 73.4 µM 0.289838742008898 0.385567964183509 no 1285 0.38596980377442 1872 4315245
SGTC_1357 1503-1303 39.5 µM 0.289395512593481 0.38575182090433 no 1286 0.386139364296047 1792 292895
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.289355578450465 0.385768387312897 no 1287 0.386154642451137 1824 4000243
SGTC_1473 k844-0725 134 µM 0.286642244653083 0.386894481980254 no 1288 0.387193132270762 1838 54682906
SGTC_1581 himbacine 57.9 µM 0.2858944647498 0.387204995372367 no 1289 0.387479476689523 1767 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2361 9034121 116 µM 0.285880842080314 0.387210652815678 no 1290 0.387484693733068 1780 6496917
SGTC_2545 solidagenone 89.61 µM 0.285798596203554 0.387244809727323 no 1291 0.387516191685823 1816 6708572 An anti ulcer agent
SGTC_1655 st012546 55.1 µM 0.2857292942885 0.387273591658087 no 1292 0.387542733025107 1829 720985 YLR208W SEC13
SGTC_3223 9129970 49.47 µM 0.284996873343712 0.387577812865142 no 1293 0.387823268675097 1807 17248386
SGTC_2380 9035439 200 µM 0.284578627587893 0.387751568026475 no 1294 0.387983493601977 1880 6462575
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.284029855817373 0.387979582742099 no 1295 0.388193750401995 1792 688667
SGTC_1967 st070177 51.4 µM 0.283880220106153 0.38804176309781 no 1296 0.38825108762234 1867 5729214
SGTC_1559 coumarin 343 70.1 µM 0.283251884441398 0.388302896090744 no 1297 0.388491879051681 1867 108770 A hepatotoxic, DNA x-linker.
SGTC_1774 st048371 48.465 µM 0.281854771048572 0.388883709882638 no 1298 0.3890274357295 1750 4242727
SGTC_1308 1187-1617 41.4 µM 0.281465321143579 0.389045657951756 no 1299 0.389176761532122 1790 2882570
SGTC_2925 9010536 32.5 µM 0.280131783675944 0.389600339371454 no 1300 0.389688200329732 1864 2994177
SGTC_1310 1188-0297 994 nM 0.279645282871664 0.389802754173782 no 1301 0.389874830921313 1856 1588352
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.277827497059877 0.390559330992128 no 1302 0.39057239111193 2030 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2625 euphol 100 µM 0.275910822144438 0.391357515227258 no 1303 0.39130828078628 1952 6708538 A triterpene alcohol.
SGTC_1481 3346-2004 36 µM 0.274867988551153 0.391791987581845 no 1304 0.391708830808717 1843 2770522
SGTC_1186 1319-0216 26 µM 0.274850324257255 0.391799348163051 no 1305 0.391715616614169 1973 4565136
SGTC_3341 9147222 25.867 µM 0.27481986696117 0.391812039585036 no 1306 0.391727316977276 1844 1939759
SGTC_3158 9100007 49.47 µM 0.27260054296098 0.392737131196248 no 1307 0.392580147260281 1761 19297233
SGTC_978 1416-0512 87.4 µM 0.272413512209073 0.392815119904848 no 1308 0.39265204209896 1830 6814003
SGTC_3094 9117742 49.47 µM 0.272300987950447 0.392862042720116 no 1309 0.392695298319957 1770 17149698
SGTC_2649 anisomycin 9.56 µM 0.270837617090284 0.393472412513969 no 1310 0.393257963251619 1834 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_311 1315-0136 58 µM 0.26912286590347 0.394187965813137 no 1311 0.393917567450398 1916 6759207
SGTC_197 4544-0043 41.561 µM 0.268755701508217 0.394341227390005 no 1312 0.394058842258001 1842 896523
SGTC_1058 3448-5425 97.3 µM 0.266790709182916 0.395161731000513 no 1313 0.394815154032498 1927 7279705
SGTC_927 2425-1185 123 µM 0.26598368298081 0.395498848375991 no 1314 0.395125887805044 1773 730375
SGTC_1153 4055-0057 267 µM 0.265877594443834 0.395543170341399 no 1315 0.395166740627579 1784 882706
SGTC_648 0375-0473 33.3 µM 0.265856701083157 0.395551899387256 no 1316 0.395174786427724 1841 1713139
SGTC_1986 st071812 45 µM 0.265216410032196 0.395819432239462 no 1317 0.395421377024829 1855 11838594
SGTC_3099 9120367 49.47 µM 0.263209658875492 0.396658230674072 no 1318 0.396194493255476 1836 24824940
SGTC_3014 9081533 49.47 µM 0.262688191818758 0.396876276258187 no 1319 0.396395459406258 1957 21367265
SGTC_1926 methyl fluorone black 53.6 µM 0.260691605226675 0.39771142399728 no 1320 0.397165170166387 1863 72721 Reacts with homocysteine.
SGTC_1534 6-azauridine 81.6 µM 0.260605571569343 0.397747421390768 no 1321 0.397198346315157 1847 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1931 st074438 57.1 µM 0.259328683260125 0.398281787176219 no 1322 0.397690825078012 1930 2787313
SGTC_3242 9133940 49.47 µM 0.256846848289476 0.39932095687538 no 1323 0.398648501592027 1919 17248444
SGTC_602 3130-1533 38.1 µM 0.256559367888516 0.3994413741288 no 1324 0.398759472481294 1951 720941
SGTC_1275 0867-0008 21.1 µM 0.256277213875895 0.399559569614742 no 1325 0.398868395279686 1868 3422836
SGTC_449 xestospongin c 11.1929 µM 0.256094831996626 0.39963597503932 no 1326 0.398938806212934 1923 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.255574794038368 0.399853856160226 no 1327 0.399139591785617 1962 1241132 A phosphatase inhibitor.
SGTC_1844 rapamycin 4 nM 0.254148296192543 0.400451678103062 no 1328 0.399690496490316 1864 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_673 1082-0474 110 µM 0.2538429561322 0.400579671493396 no 1329 0.39980844293721 1799 3098046
SGTC_339 3091-4833 71.4 µM 0.253833729328543 0.400583539379719 no 1330 0.399812007199865 1897 3240077
SGTC_2350 9023895 38.85 µM 0.251573273814509 0.401531417684798 no 1331 0.400685459363861 1913 2997209
SGTC_1715 st032160 10.2275 µM 0.250562174833571 0.401955590463737 no 1332 0.401076314518949 1941 5289825
SGTC_1462 k081-0014 26.5 µM 0.249059800790632 0.402586074469413 no 1333 0.401657262050157 1827 3270634
SGTC_2999 9069765 71.4286 µM 0.248882264514109 0.402660595849604 no 1334 0.40172592729274 1916 2097066
SGTC_83 0170-0301 39.027 µM 0.248639045886649 0.402762693333198 no 1335 0.401820001251951 1944 3089716
SGTC_3133 9127736 49.47 µM 0.246372465823342 0.403714468522183 no 1336 0.402696959260697 2039 27243420
SGTC_2959 9079155 11 µM 0.245898015085604 0.403913770776326 no 1337 0.402880590198958 1886 16189457
SGTC_3121 9125696 49.47 µM 0.24496066833315 0.404307594782908 no 1338 0.403243442886313 2026 1235365
SGTC_3147 9097027 49.47 µM 0.244476317210629 0.404511131786179 no 1339 0.403430970853141 1905 25236841
SGTC_1271 0832-2808 169 µM 0.24438460269495 0.404549675535064 no 1340 0.403466482794052 1987 3663794
SGTC_650 1328-0195 38 µM 0.242789560922875 0.405220152252655 no 1341 0.40408421141611 1974 2780821
SGTC_107 0358-0022 2.6945 µM 0.242189204093532 0.405472584772883 no 1342 0.404316779983804 1976 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2314 7727897 200 µM 0.241362977241327 0.405820053320678 no 1343 0.404636902240912 1811 900724
SGTC_3061 glucosamine 200 µM 0.241236866946607 0.405873095363718 no 1344 0.404685769397136 2001 91431 and experimental redox chemotherapeutic
SGTC_682 0kpi-0099 17 µM 0.239799160755089 0.406477917110238 no 1345 0.405242978806215 1833 1714895 YML126C ERG13
SGTC_2258 7960471 200 µM 0.239143505113536 0.406753815938176 no 1346 0.405497154034606 1842 2974708
SGTC_1469 k284-2957 126 µM 0.237284995235544 0.407536125004592 no 1347 0.406217850906326 1938 23884841
SGTC_3084 9116877 49.47 µM 0.236907153701291 0.407695216387489 no 1348 0.406364410052201 1995 27241325
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.236508368618265 0.40786314263024 no 1349 0.406519107121221 2018 756377
SGTC_2447 5741742 33.78 µM 0.235510634478938 0.408283357175736 no 1350 0.406906212918085 1926 1776504
SGTC_1358 1509-0022 2.48 µM 0.234545409325745 0.408689980351373 no 1351 0.407280792296199 1925 3258434
SGTC_1495 4469-0029 237 µM 0.234448541653247 0.408730793509612 no 1352 0.407318388868978 1865 793680
SGTC_414 piperonyl butoxide 100 µM 0.233919901662963 0.408953542288926 no 1353 0.407523581250078 1837 5794 A potent inhibitor of cytochrome P450.
SGTC_179 1273-0063 6.77 µM 0.233807926996337 0.409000727929862 no 1354 0.407567047638348 1830 3108139
SGTC_2026 5148700 152 µM 0.233204393602891 0.409255076988632 no 1355 0.40780134714994 1875 79838
SGTC_1726 st035556 14.5795 µM 0.233181294134064 0.409264812633423 no 1356 0.407810315319908 1979 5919439
SGTC_838 0109-0203 71.4 µM 0.233157415069139 0.409274876910431 no 1357 0.40781958621213 1900 759422
SGTC_483 fpl-64176 144 µM 0.232271565857775 0.409648276775733 no 1358 0.408163547860761 1935 3423
SGTC_1567 st069303 68.4 µM 0.231934519762081 0.409790368737448 no 1359 0.408294436287309 1882 5581319
SGTC_214 4373-3496 70 µM 0.23180363749762 0.40984554930397 no 1360 0.408345265843786 1969 3779166
SGTC_3130 9127414 49.47 µM 0.23081124914382 0.410264002834632 no 1361 0.408730720814097 2023 1494646
SGTC_1605 st000082 49.1 µM 0.230070629863981 0.410576361261713 no 1362 0.409018443359776 1953 1114022
SGTC_1257 0669-0121 16 µM 0.228827931385451 0.411100600466002 no 1363 0.40950132829993 1978 4307855
SGTC_1737 st035557 69.7 µM 0.227572554873121 0.411630349213959 no 1364 0.409989279082543 1815 5716916
SGTC_2325 6158266 200 µM 0.227045091751892 0.411852978317063 no 1365 0.41019433972572 1889 3623240
SGTC_1658 st012944 20 µM 0.22595865723978 0.41231162472446 no 1366 0.410616787739226 1985 24207260
SGTC_216 k038-0035 28.382 µM 0.225840417596254 0.412361547707582 no 1367 0.410662770180312 1991 4444231 YPR107C YTH1
SGTC_1154 4088-0362 150 µM 0.225475628829966 0.412515577261861 no 1368 0.410804641316418 1889 6618304
SGTC_1531 st059297 52.4 µM 0.225460262485151 0.412522065891457 no 1369 0.410810617745738 1928 7566702
SGTC_3276 9139060 49.47 µM 0.223829664299972 0.413210741717055 no 1370 0.411444923368466 1925 4870619
SGTC_384 k007-0144 5.16 µM 0.223297406488033 0.413435596348766 no 1371 0.41165202281776 1926 6824886
SGTC_818 4072-2707 53.5 µM 0.222999612545397 0.413561413088831 no 1372 0.411767904027716 1893 882871
SGTC_2863 9028737 58.44 µM 0.222153194746708 0.413919069618513 no 1373 0.412097314431165 2058 6460917
SGTC_1327 1436-0082 2.18 µM 0.221032490929659 0.41439273640691 no 1374 0.412533567233871 1909 15992205
SGTC_2897 9048598 12.99 µM 0.220874223018519 0.414459638576504 no 1375 0.412595184400454 1899 6467404
SGTC_2479 5617353 43.85 µM 0.220391217297022 0.414663827522025 no 1376 0.412783242425351 1980 2731746
SGTC_2262 9014885 67.46 µM 0.220200373017921 0.414744512619012 no 1377 0.412857553065709 2026 6457424
SGTC_1335 1486-0900 202 µM 0.220057671106727 0.414804846448116 no 1378 0.412913120148527 1923 X1335
SGTC_2875 9039966 71.43 µM 0.219682360487452 0.414963535950281 no 1379 0.413059271691719 2012 6463691
SGTC_1670 st016595 4.04 µM 0.21865021693657 0.415400020196231 no 1380 0.413461265839014 2039 597879
SGTC_539 4859-0462 2.54 µM 0.218470185823548 0.415476164448718 no 1381 0.413531392767963 2049 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_830 4076-0286 57.8 µM 0.21818294713958 0.415597658770088 no 1382 0.413643285620576 1919 6866659
SGTC_3086 9117350 49.47 µM 0.217952768653686 0.415695023970156 no 1383 0.413732955928862 1962 2679265
SGTC_2966 9084041 48.03 µM 0.217355129210276 0.415947848828193 no 1384 0.41396579847711 1717 17741380
SGTC_259 usnic acid 108.925 µM 0.216541314874998 0.416292180043585 no 1385 0.414282912190103 1990 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.214793134464094 0.417032065793436 no 1386 0.414964302940191 1970 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1313 1220-0047 237 µM 0.21251008661934 0.417998766751282 no 1387 0.415854554752122 1967 3528706
SGTC_3155 9099265 49.47 µM 0.212185270813279 0.418136342496498 no 1388 0.415981248655215 1965 25236499
SGTC_698 k064-0052 127 µM 0.210891629306307 0.418684363630167 no 1389 0.416485918042588 1978 5088751
SGTC_3334 9142812 21.919 µM 0.209208785400166 0.419397497391932 no 1390 0.417142627209199 1980 45283678
SGTC_3224 9130643 49.47 µM 0.208998836113667 0.41948648560644 no 1391 0.41722457360075 1971 17644395
SGTC_1433 4060-0023 7.6 µM 0.207578662131136 0.42008854244614 no 1392 0.41777898330451 2001 3840627
SGTC_3138 9097216 49.47 µM 0.207284984300465 0.420213065187446 no 1393 0.417893650139331 2114 25237486
SGTC_2301 7769476 200 µM 0.206972348598752 0.420345635058148 no 1394 0.418015726766739 1953 977820
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.206951149678254 0.420354624564023 no 1395 0.418024004715011 1899 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_90 0870-0863 4.608 µM 0.206623037537757 0.42049376741608 no 1396 0.418152133572051 1891 1738164
SGTC_2070 5230947 200 µM 0.205328972239373 0.421042639716527 no 1397 0.418657554841726 2055 2835538
SGTC_2285 7945142 200 µM 0.20523354348142 0.421083121508978 no 1398 0.418694831645412 1921 2970608
SGTC_2938 9059746 27.26 µM 0.204797702746565 0.421268019921032 no 1399 0.418865090958496 1986 6471769
SGTC_154 3389-1638 511.116 µM 0.204451496745269 0.421414904617771 no 1400 0.419000345679917 1800 5238686
SGTC_1046 2001-0062 216 µM 0.204055289046758 0.421583016935509 no 1401 0.419155146661362 1894 739778
SGTC_2884 9058502 51.95 µM 0.203417426177999 0.421853694407656 no 1402 0.41940439020861 1937 6471554
SGTC_1441 4106-0040 13 µM 0.202847724999162 0.422095478647115 no 1403 0.419627027067335 2034 2904180
SGTC_501 nsc-95397 161 µM 0.201498800341337 0.422668086433531 no 1404 0.420154283692224 2029 262093
SGTC_249 wiskostatin 11.211 µM 0.200467369367958 0.423106031010799 no 1405 0.420557537732263 2036 2775510 A n-wasp and actin depolymerizer.
SGTC_372 0155-0182 15.9 µM 0.198602955689197 0.423897900020585 no 1406 0.421286670682247 1981 771486
SGTC_403 arphamenine a 50 µM 0.198114149075994 0.424105560948128 no 1407 0.421477877438647 1971 5487158 An arginine aminopeptidase inhibitor.
SGTC_2452 5863136 48.41 µM 0.197194587341299 0.42449627771227 no 1408 0.421837633066528 1969 2184096
SGTC_3202 9113761 49.47 µM 0.19713502734877 0.424521586991024 no 1409 0.421860936683151 2055 4798415
SGTC_2022 5136654 200 µM 0.196416310845293 0.424827021145008 no 1410 0.422142165350523 1964 1713771
SGTC_1449 4112-4002 201 µM 0.196273509251612 0.424887713157844 no 1411 0.42219804733317 1885 2059539
SGTC_1189 1431-2119 7.28 µM 0.196021094561997 0.42499499611583 no 1412 0.422296827605391 1993 3107275
SGTC_348 k064-0012 10.7 µM 0.195184028413428 0.425350811212314 no 1413 0.422624441038453 1935 5066323
SGTC_122 0236-0016 402.397 µM 0.194043067644774 0.425835901903892 no 1414 0.423071079816018 2000 6808838
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.192122689455844 0.426652622699907 no 1415 0.423823051176602 1970 364106
SGTC_1014 4130-3005 69.3 µM 0.191259043135393 0.427020027027509 no 1416 0.424161323775625 1910 743608
SGTC_1109 tnp00067 928.257 nM 0.190255296033181 0.427447111256823 no 1417 0.424554541181988 1937 676295
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.189959151014661 0.427573134232249 no 1418 0.424670570203682 1951 6708514
SGTC_993 3909-8757 62.7 µM 0.188910248898087 0.428019548438142 no 1419 0.425081580375315 1967 4288324 YLR208W SEC13
SGTC_2636 apigenin dimethyl ether 100 µM 0.188727409784737 0.428097374467238 no 1420 0.425153233860467 1989 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_263 alizarin 107.927 µM 0.188372189385796 0.428248583111964 no 1421 0.425292449540738 2003 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1748 st037455 53.6035 µM 0.188246112405134 0.428302253536577 no 1422 0.425341863056047 1978 580690
SGTC_365 0121-0052 13.6 µM 0.187714291601268 0.428528661934039 no 1423 0.425550313175008 2014 3101739
SGTC_1320 1313-0481 95.3 µM 0.187003719407198 0.42883120562788 no 1424 0.425828858362865 2067 6813365 YLR208W SEC13
SGTC_3194 9111903 49.47 µM 0.186698816872602 0.428961038259801 no 1425 0.425948391894527 2018 17087251
SGTC_2221 6807166 181.081 µM 0.186225904787055 0.42916242738894 no 1426 0.426133805096262 2042 674925
SGTC_861 0443-0273 110 µM 0.185891416980851 0.429304879817053 no 1427 0.426264956574126 2017 6149169
SGTC_528 3492-0019 172 µM 0.184182600833338 0.430032777606095 no 1428 0.426935104250303 2082 2869262
SGTC_2355 9061122 103.12 µM 0.183889975636283 0.430157449949162 no 1429 0.427049884495036 2076 5302957
SGTC_2926 9010726 65.15 µM 0.183248006179417 0.430430984049931 no 1430 0.427301714276922 1913 2994293
SGTC_1615 st002656 86.5 µM 0.182973025466492 0.430548159660779 no 1431 0.427409591924664 2095 1584458
SGTC_2933 9026794 32.47 µM 0.182927080521236 0.430567738455964 no 1432 0.427427617109602 2014 17586027
SGTC_2984 9022109 38.96 µM 0.182075774650397 0.43093054136379 no 1433 0.427761629984975 2132 6459207
SGTC_1299 1079-1439 3.74 µM 0.180323728961648 0.431677397670448 no 1434 0.428449213994175 1956 323161
SGTC_2329 6138490 200 µM 0.179807251568895 0.431897606705497 no 1435 0.428651945238675 1947 720019
SGTC_178 4092-0806 87.505 µM 0.177735761429335 0.432781034197442 no 1436 0.429465249406223 2074 2169044
SGTC_1951 sophoraflavanone G 9.2 µM 0.176889274485313 0.433142132093454 no 1437 0.429797681746446 1878 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2241 6772625 37.8075 µM 0.176391916130287 0.433354323330961 no 1438 0.429993027544102 2143 2285411
SGTC_3261 9137475 49.47 µM 0.174529165675923 0.434149210945817 no 1439 0.430724805800256 2119 17027690
SGTC_1483 3453-0561 55.9 µM 0.174512092292849 0.43415649787161 no 1440 0.430731514153128 2065 4546991
SGTC_1674 st016616 23.6 µM 0.174485979130934 0.434167643021413 no 1441 0.430741774390603 1893 625830
SGTC_2255 7941087 197.44 µM 0.174214149493264 0.434283663561159 no 1442 0.430848582945925 2111 935561
SGTC_797 k781-0471 270 µM 0.17214301224542 0.435167837915515 no 1443 0.431662549285665 2045 23738129
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.171667412150362 0.435370918882003 no 1444 0.431849503383639 2002 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1661 st013063 9.66 µM 0.171261804958325 0.435544126389649 no 1445 0.432008955965898 2008 721395
SGTC_1038 k292-0204 154 µM 0.171245691699844 0.435551007532463 no 1446 0.43201529065024 1960 4454212
SGTC_2714 st079313 56.9 µM 0.170534162559837 0.43585488440875 no 1447 0.432295034995978 1995 2939799
SGTC_2158 5657123 3.6195 µM 0.168667936519057 0.436652083875044 no 1448 0.433028920170546 2117 2858827
SGTC_2081 5214970 32.255 µM 0.168132927549644 0.436880672319576 no 1449 0.433239352813188 2102 2063512
SGTC_1332 1480-0653 17.5 µM 0.167645453459823 0.437088969318553 no 1450 0.433431105261223 2139 5749438
SGTC_2173 5763948 167 µM 0.167235141025995 0.437264308770084 no 1451 0.433592517605695 2114 2867177
SGTC_963 1269-2853 151 µM 0.16700328609232 0.437363393151111 no 1452 0.433683731655406 1968 3668223
SGTC_2214 7179297 48.276 µM 0.165290489169848 0.438095486900469 no 1453 0.434357672200025 2060 769744
SGTC_2474 5321570 43.32 µM 0.1652373172797 0.438118217347337 no 1454 0.434378597004324 2099 2841384
SGTC_1937 st074714 47.2 µM 0.164810227211773 0.438300801444479 no 1455 0.434546676988031 1923 17250970
SGTC_453 enantio-paf c16 10 µM 0.164413576198922 0.438470384389131 no 1456 0.43470278837236 2090 13871343 A lipid and platelet activating factor
SGTC_2823 7987624 58.44 µM 0.162347189133171 0.439354023154703 no 1457 0.435516227992317 2031 2239440
SGTC_1284 0929-0043 16 µM 0.162269857566507 0.439387097960798 no 1458 0.435546675120467 2013 1239883
SGTC_3137 9097352 49.47 µM 0.161313591869696 0.439796128870787 no 1459 0.435923209346373 2078 44120435
SGTC_1695 st026914 34.495 µM 0.161271278190788 0.43981422951546 no 1460 0.435939871905835 1992 3289191
SGTC_2991 9074669 71.4286 µM 0.158016388865041 0.441206957143923 no 1461 0.437221942257646 2086 17333109
SGTC_596 1155-0152 116 µM 0.15776815425012 0.441313203791419 no 1462 0.437319746778987 2019 280313
SGTC_1032 k061-1018 98.7 µM 0.155557137952571 0.44225972411814 no 1463 0.438191056257455 2158 4005393
SGTC_1841 st054148 70 µM 0.155007247842441 0.442495179566682 no 1464 0.438407801709572 1994 675442
SGTC_1821 st053465 65.6 µM 0.152809009558333 0.443436637332623 no 1465 0.439274446291635 2022 675086
SGTC_373 0844-0104 25.9 µM 0.151547645850021 0.443976996594353 no 1466 0.439771864433045 2156 5375804
SGTC_3246 9135460 32.98 µM 0.148323715892256 0.445358576349436 no 1467 0.441043649894621 2095 41446951
SGTC_1370 2001-0092 44.6 µM 0.147035080906632 0.44591099336833 no 1468 0.441552165336835 2129 790957
SGTC_3008 9078912 71.4286 µM 0.146842248711355 0.445993666477013 no 1469 0.441628268234093 2043 16648731
SGTC_2558 carylophyllene oxide 100 µM 0.145892291207985 0.446400976761215 no 1470 0.442003208600887 2172 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_340 k038-0059 454 µM 0.145591115087676 0.446530122925486 no 1471 0.442122091189057 2073 23733424
SGTC_1276 0871-0068 94.2 µM 0.14545939593254 0.446586606689064 no 1472 0.442174086040839 2116 3414906
SGTC_2087 5276107 200 µM 0.14471570968605 0.44690553427281 no 1473 0.442467667598255 2117 144405
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.142510458706971 0.447851450557042 no 1474 0.443338409416933 2151 5355888
SGTC_2446 5162541 200 µM 0.140199074931229 0.448843209559909 no 1475 0.4442513513924 2043 1549321
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.139319189957554 0.44922083133297 no 1476 0.444598963183686 2010 688788
SGTC_2747 doxorubicin 7.63 µM 0.139129374062811 0.449302300996092 no 1477 0.444673958404749 2182 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2753 fluvastatin 17.09 µM 0.138683107761013 0.449493848507534 no 1478 0.44485028357521 2084 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_394 menadione 8.33 µM 0.13864842126576 0.449508737223229 no 1479 0.444863989083199 2158 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1974 st069448 26.9 µM 0.137371091488416 0.45005706333699 no 1480 0.445368740023544 2174 6323587 YNR016C ACC1
SGTC_2432 5630864 12.22 µM 0.136131359880897 0.450589340686342 no 1481 0.445858718343292 2070 5714970
SGTC_1853 st056710 91.2 µM 0.134811942491749 0.451155928647474 no 1482 0.446380281648526 2204 269167
SGTC_932 2857-0803 154 µM 0.134591732804154 0.451250501439788 no 1483 0.44646733919817 2158 674898
SGTC_497 capsazepine 133 µM 0.133920263430487 0.451538892433301 no 1484 0.446732813360234 2013 2733484 A calcium channel blocker.
SGTC_2531 methyl deoxycholate 70.07 µM 0.133640917302068 0.451658877015326 no 1485 0.446843263528904 2065 16667744 Haematoxylin.
SGTC_1588 farnesol 29.9 µM 0.133583412742613 0.45168357688777 no 1486 0.446866000666403 2033 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_753 1322-0200 289 µM 0.131497354803122 0.452579724852154 no 1487 0.447690939483571 2102 5403907
SGTC_64 000l-0018 272.079 µM 0.131350149092348 0.452642972015484 no 1488 0.447749161080443 1978 6811119
SGTC_2075 5212009 200 µM 0.130774546935263 0.452890291900658 no 1489 0.447976829326061 2163 780898
SGTC_2617 dihydrotanshinone i 20.83 µM 0.130729249582749 0.452909755662414 no 1490 0.447994746541815 2091 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1202 1988-0068 29.6 µM 0.130563023565455 0.452981182077287 no 1491 0.448060497593847 2011 2850480
SGTC_728 3030-5151 22.5 µM 0.129891435219048 0.453269775400332 no 1492 0.448326160292979 2111 3125388
SGTC_2170 morpholine 200 µM 0.129549970159064 0.453416518416101 no 1493 0.448461243791131 2137 121171 Reacts with secondary amines.
SGTC_2439 5492030 7.2 µM 0.129312672959884 0.453518499527184 no 1494 0.448555122028129 2185 5722370
SGTC_2601 securinine 100 µM 0.12851988076059 0.453859232983184 no 1495 0.448868783058393 2075 442872 A GABA receptor antagonist.
SGTC_3244 9134489 49.47 µM 0.127967047702689 0.454096854727545 no 1496 0.449087525360163 2053 16584271
SGTC_1114 scopoletin 1.73284 µM 0.127057881587438 0.454487673197408 no 1497 0.449447293418397 2189 5280460 A coumarin with genotoxic properties.
SGTC_1720 st037298 9.481 µM 0.126392053315837 0.454773917278069 no 1498 0.449710796121603 2075 597396
SGTC_324 1315-0088 19.6 µM 0.126313466395445 0.454807703879543 no 1499 0.449741898498223 2150 6787421
SGTC_556 4058-0063 51.5 µM 0.125896883601083 0.45498680932626 no 1500 0.449906774787369 2081 6615692
SGTC_3305 9127027 53.8275 µM 0.125850849650603 0.455006601707388 no 1501 0.449924994762552 2099 41905295
SGTC_1326 1431-2094 10.8 µM 0.124543091308229 0.455568921267594 no 1502 0.450442642008217 2119 616278
SGTC_2100 5377183 190 µM 0.124239528269714 0.455699462309461 no 1503 0.450562812819512 2141 2844202
SGTC_1172 0370-0043 85 µM 0.124030655502845 0.455789286525823 no 1504 0.450645501440617 2126 376585
SGTC_1764 st044502 93.5 µM 0.123902251769013 0.455844506740877 no 1505 0.450696335017364 2085 8407
SGTC_1409 3909-8004 61.9 µM 0.123073382293812 0.456200983758627 no 1506 0.4510244944326 2095 2119279
SGTC_759 3486-0358 89.3 µM 0.122523449059542 0.456437516417424 no 1507 0.451242238116162 2221 875103
SGTC_2807 7945238 51.95 µM 0.121424061645197 0.456910421883203 no 1508 0.451677579723141 2121 17148797
SGTC_1329 1447-1697 50.6 µM 0.121416159478029 0.456913821250652 no 1509 0.451680709078701 2107 2840515
SGTC_490 phenamil 164 µM 0.121249430588785 0.456985545696908 no 1510 0.451746736472774 2189 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2085 5307070 144.047 µM 0.121221066622836 0.456997747619589 no 1511 0.451757969204694 2074 2840351
SGTC_360 0957-0399 1.01 µM 0.119799373435258 0.457609398928049 no 1512 0.452321039147703 2177 6752301 YPR165W RHO1
SGTC_1336 1486-0901 104 µM 0.119350102257663 0.457802708629944 no 1513 0.452498995634459 2107 5006114
SGTC_428 3448-4153 16.5 µM 0.118455390095729 0.458187709692003 no 1514 0.452853419856198 1974 3834874
SGTC_854 0422-0053 192 µM 0.115976963746603 0.459254398085438 no 1515 0.453835399422034 2182 3596728
SGTC_2401 5128683 200 µM 0.114555476135567 0.459866324158463 no 1516 0.454398736095594 2111 708373
SGTC_2961 9083290 32.55 µM 0.113395977126041 0.460365539100632 no 1517 0.454858314464969 2216 17741490
SGTC_3239 9133757 49.47 µM 0.112729533606389 0.460652500456658 no 1518 0.455122493027972 2153 17036923
SGTC_1164 k060-0068 93.7 µM 0.112363291027799 0.460810208177021 no 1519 0.455267680237623 2216 5963676
SGTC_1784 st039334 36.3 µM 0.112161288982356 0.460897194918925 no 1520 0.455347761177971 2222 3496984
SGTC_2739 tacrine 100.86 µM 0.112154310377629 0.460900200100611 no 1521 0.455350527782542 2135 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2865 9030313 51.95 µM 0.112048278782799 0.460945860534996 no 1522 0.455392563313269 2078 42562754
SGTC_2242 6630449 61.2675 µM 0.111906575415113 0.46100688312507 no 1523 0.455448741464131 2131 691249 YDR170C SEC7
SGTC_1183 1254-0324 198 µM 0.11086820182239 0.461454072235988 no 1524 0.45586043069147 2167 5799357
SGTC_1487 3970-0795 2.82 µM 0.110255495203715 0.461717965222501 no 1525 0.456103375845021 2143 3765103
SGTC_2957 9076800 11.52 µM 0.10955387291289 0.462020174919452 no 1526 0.456381597228079 2110 16459615
SGTC_3229 9132204 49.47 µM 0.10954954372596 0.462022039697941 no 1527 0.456383313990883 2126 17682924
SGTC_165 k038-0023 64.381 µM 0.108954057892938 0.462278550574453 no 1528 0.456619464906278 2170 46368543
SGTC_535 2293-4129 48.2 µM 0.108951828547329 0.462279510914662 no 1529 0.456620349023331 2203 396118 YIL048W NEO1
SGTC_3068 9116768 49.47 µM 0.108941153714184 0.462284109339531 no 1530 0.456624582466824 2122 41904888
SGTC_6 0844-0013 19.835 µM 0.108447323365814 0.462496843388159 no 1531 0.456820431920746 2214 1584900
SGTC_3173 9105693 49.47 µM 0.107390366220132 0.462952199238908 no 1532 0.45723964847568 2176 17096658
SGTC_235 0330-0087 5 mM 0.105293511188686 0.463855704632194 no 1533 0.458071455838393 2166 46494818 YHR062C RPP1
SGTC_407 eburnamonine 100 µM 0.103515366483965 0.464622028496167 no 1534 0.458776977159466 2086 3195
SGTC_2843 9000894 45.46 µM 0.103309040499362 0.464710956991349 no 1535 0.458858850366156 2242 2242070
SGTC_1608 st001473 40.5 µM 0.103286121905611 0.464720835235807 no 1536 0.458867944911372 2043 7292267
SGTC_1998 st075797 76.8 µM 0.102142620048243 0.465213728510223 no 1537 0.459321735997594 2236 24208315
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.101371595877943 0.465546099752005 no 1538 0.459627741752951 2164 688669
SGTC_800 3448-7362 155 µM 0.10050607973387 0.465919232989955 no 1539 0.459971278175183 2232 15991913
SGTC_578 3460-0051 92 µM 0.100027047732143 0.466125761694718 no 1540 0.460161426071315 2238 2876744
SGTC_2887 9044784 58.44 µM 0.0999576747023767 0.466155671773412 no 1541 0.460188963893236 2256 6465546
SGTC_313 3474-0040 5.03 µM 0.0995832819007158 0.466317093968848 no 1542 0.460337583475941 2198 1043375 YIL048W NEO1
SGTC_1787 fluconazole 80 µM 0.0991975644365475 0.466483404670188 no 1543 0.460490704310169 2163 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_194 1486-1323 56.904 µM 0.0985509455726412 0.466762221953152 no 1544 0.460747410045265 2106 5178754
SGTC_171 k064-0041 9.68 µM 0.0973169644105306 0.467294350676412 no 1545 0.461237342146612 2119 53325
SGTC_1590 st077108 57.8 µM 0.0956961427810738 0.46799338497636 no 1546 0.461880952228121 2234 5489485
SGTC_2790 5423970 71.43 µM 0.094608072163395 0.468462707837951 no 1547 0.462313068969927 2221 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1732 st034308 51.822 µM 0.0942723312189758 0.468607533513684 no 1548 0.462446414249355 2018 830119
SGTC_3003 9075612 71.4286 µM 0.0934777638401417 0.468950295706689 no 1549 0.462762007110072 2171 6501993
SGTC_2167 5876490 200 µM 0.092264489591154 0.469473724890847 no 1550 0.463243950595868 2203 686534
SGTC_1004 4084-0029 199 µM 0.0915177010968201 0.469795929692388 no 1551 0.463540620907973 2241 716894 YLR208W SEC13
SGTC_2295 7971645 200 µM 0.0895928057397367 0.470626523967918 no 1552 0.464305400801849 2179 2978226 YKL099C UTP11
SGTC_2090 5301565 104.445 µM 0.0874596366574657 0.471547137710261 no 1553 0.465153083863427 2186 2056344
SGTC_2539 epi(13)torulosol 80 µM 0.0865950593293089 0.471920307723411 no 1554 0.465496696616607 2156 6708597
SGTC_1568 digitonin 820 nM 0.0864290217011505 0.47199197593651 no 1555 0.465562688630784 2265 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1871 st057448 67.3 µM 0.0851635946707607 0.472538212437924 no 1556 0.466065666320636 2234 691747
SGTC_756 0508-1999 28.3 µM 0.0849493172933836 0.47263071293668 no 1557 0.466150841962236 2080 6753853
SGTC_1573 oleylamine 1.06 µM 0.0845491106211761 0.472803480418849 no 1558 0.466309928980903 2208 5356789 An amine of the fatty acid oleic acid.
SGTC_164 4100-3994 89.624 µM 0.084134934356724 0.472982283900488 no 1559 0.466474574750319 2259 4615967
SGTC_632 0781-2353 4.65 µM 0.0833936634453155 0.473302310542403 no 1560 0.466769263400565 2196 6811515 YHR007C ERG11
SGTC_2406 ethylparaben 405.7 µM 0.0819336950661236 0.473932668460732 no 1561 0.467349719859995 1913 8434 A possible steroid mimic.
SGTC_2351 9026858 72.31 µM 0.0819286489764215 0.473934847281332 no 1562 0.467351726213173 2234 1409300
SGTC_438 sphingosine 6.67 µM 0.0819041916137172 0.473945407589326 no 1563 0.467361450607626 2188 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_413 propylparaben 100 µM 0.0818007109999855 0.47399008910789 no 1564 0.467402595337289 2142 7175 A pharmaceutical preservative.
SGTC_3055 9094636 49.47 µM 0.0817824030898176 0.473997994248044 no 1565 0.467409874746841 2228 25236176
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0810319107616073 0.474322056779897 no 1566 0.467708287411605 2257 551469
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0809074958367317 0.474375780782859 no 1567 0.467757759348021 2215 688761
SGTC_2835 9006588 71.43 µM 0.0791789586109816 0.475122233696296 no 1568 0.468445140317718 2109 2345538
SGTC_1770 st043884 66.3 µM 0.0784195407529764 0.475450209085472 no 1569 0.468747165061026 2266 670149
SGTC_2886 9058944 51.95 µM 0.0775461757779812 0.475827416209035 no 1570 0.469094529439292 2267 4949929
SGTC_944 3370-0224 231 µM 0.0775230931728559 0.475837385902435 no 1571 0.469103710428595 2210 4580514
SGTC_2116 5511452 16.8835 µM 0.0774941195304001 0.475849900036979 no 1572 0.469115234571417 2197 870744
SGTC_720 r052-1644 49.9 µM 0.0773929950876456 0.47589357733058 no 1573 0.469155456590296 2213 1422863 YOR257W CDC31
SGTC_658 3253-0951 102 µM 0.0763456414501918 0.476345963361999 no 1574 0.469572057574698 2206 1184878
SGTC_1420 4'-methoxyflavone 42 µM 0.0761655597284346 0.47642374959084 no 1575 0.469643691212458 2266 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2336 9001819 198.65 µM 0.0757741982739536 0.476592801110933 no 1576 0.469799371944113 2228 2989602
SGTC_722 3534-0461 190 µM 0.0752255073908477 0.47682981934635 no 1577 0.470017644943243 2194 658262
SGTC_3342 9147791 14.508 µM 0.0746215294049573 0.47709072944971 no 1578 0.47025792194576 2266 1838168
SGTC_564 3555-0129 330 µM 0.0733958642736818 0.477620229836108 no 1579 0.470745554276305 2282 563260
SGTC_1527 coumarin 137 µM 0.073299613096313 0.477661813054859 no 1580 0.47078384978897 2217 323 A hepatotoxic, DNA x-linker.
SGTC_278 4092-0821 23.9 µM 0.0727382500043393 0.4779043425479 no 1581 0.471007205024955 2226 877900
SGTC_1220 1838-0075 193 µM 0.0718151874413021 0.478303157258324 no 1582 0.471374493099321 2209 5529645
SGTC_353 1988-1175 58.3 µM 0.0714213113537294 0.478473340418373 no 1583 0.47153122445585 2206 2788357
SGTC_1949 st076024 69.1 µM 0.0713744769247606 0.478493576564849 no 1584 0.471549861127453 2285 2921930
SGTC_1724 st037281 8.293 µM 0.0712237094175464 0.478558720328718 no 1585 0.471609855972849 2239 574124 YDL195W SEC31
SGTC_1020 4335-0961 93.3 µM 0.06952313284093 0.479293546284884 no 1586 0.472286609928096 2101 669075
SGTC_2971 9092186 9.93 µM 0.0681715084926666 0.479877638908228 no 1587 0.472824553561115 2078 25236400
SGTC_1835 st008666 49.2 µM 0.0676190124747062 0.480116407735696 no 1588 0.473044460136098 2147 690455
SGTC_1231 0242-0792 125 µM 0.0662425036505885 0.480711315986996 no 1589 0.473592379023401 2239 3707635
SGTC_10 0279-0212 42.575 µM 0.0659636840412626 0.480831823276795 no 1590 0.473703369196329 2291 39851 YBR002C RER2
SGTC_1739 st037196 92.5 µM 0.0654415870124297 0.481057481039047 no 1591 0.473911206688548 2281 612214
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0652750036580264 0.481129482015097 no 1592 0.473977522040517 2218 676296 Flavone; oxidizing agent.
SGTC_1256 0570-0116 285 µM 0.0642419954666564 0.481575984445263 no 1593 0.474388769444544 2223 410638
SGTC_2654 protoveratrine a 100 µM 0.0636772918552534 0.481820078990917 no 1594 0.474613593258746 2279 5702278 A heart drug and vasodilator.
SGTC_1628 st004252 77.7 µM 0.0631372759970929 0.482053508569984 no 1595 0.474828595772289 2272 692968
SGTC_853 0419-0306 21 µM 0.0630951118633511 0.482071734879899 no 1596 0.474845383356667 2163 762713
SGTC_638 3970-0837 4.09 µM 0.0630496652726392 0.482091380140991 no 1597 0.474863477896202 2245 4118451 YLR208W SEC13
SGTC_81 0411-0046 9.971 µM 0.0629062613176906 0.482153369853285 no 1598 0.474920574455743 2288 12925265
SGTC_2551 apiole 73.87 µM 0.0619363749220858 0.482572637175658 no 1599 0.475306750046352 2293 10659 A possible DNA adduct former.
SGTC_1902 st060212 70.5 µM 0.0604449751039834 0.48321738436161 no 1600 0.475900619581984 2315 688944
SGTC_3267 9137951 49.47 µM 0.0601586494574923 0.483341170900713 no 1601 0.476014639493582 2169 16643986
SGTC_3047 9092122 49.47 µM 0.0598429262856532 0.483477668668565 no 1602 0.476140368293613 2260 17173831
SGTC_2278 7948257 134.34 µM 0.0587715963717023 0.483940855035593 no 1603 0.476567016076938 2314 1247028
SGTC_70 0141-0289 43.283 µM 0.0586625814638455 0.483987988538724 no 1604 0.476610431826145 2179 352408
SGTC_459 nigericin 15.3 µM 0.058360497344779 0.484118598289925 no 1605 0.476730739833393 2240 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_576 1073-0113 22.7 µM 0.058184201581302 0.484194822700592 no 1606 0.476800952356789 2322 5439563
SGTC_619 1652-1634 108 µM 0.0581097855059651 0.48422699790416 no 1607 0.476830589929804 2230 5400454
SGTC_1971 st069429 63.5 µM 0.0565080325690361 0.484919570758319 no 1608 0.477468548343427 2315 1246522 YGL099W LSG1
SGTC_3018 9082602 49.47 µM 0.0552657373878697 0.485456751148972 no 1609 0.477963379017261 2242 17332089
SGTC_1387 3342-1166 1.8 µM 0.0551842962791086 0.485491968000522 no 1610 0.477995819812154 2233 3418228
SGTC_973 1325-0077 65.9 µM 0.0550058338231248 0.48556913932231 no 1611 0.478066908056318 2271 2835149
SGTC_3184 9108758 49.47 µM 0.0544716878218725 0.485800119709977 no 1612 0.478279682467312 2294 902885
SGTC_142 0335-0849 62.6745 µM 0.0541634259785274 0.485933423339802 no 1613 0.478402479865353 2303 3889043 YPR107C YTH1
SGTC_3097 9117246 49.47 µM 0.0539934787104134 0.486006915391139 no 1614 0.478470179949811 2298 16423892
SGTC_1120 ficusin 1.78878 µM 0.0537687831952778 0.486104083521215 no 1615 0.478559690464077 2241 6199 A DNA cross-linker.
SGTC_3122 9126309 49.47 µM 0.0534283189256348 0.486251316674712 no 1616 0.478695321095406 2318 17591206
SGTC_2947 9072639 7.68 µM 0.0531123384669085 0.486387963526009 no 1617 0.478821200327376 2279 16488146
SGTC_1799 st045822 46.1415 µM 0.0530062215732445 0.486433854506034 no 1618 0.478863475292916 2312 3674992
SGTC_2416 tofa 880 nM 0.0528957083111684 0.486481646916756 no 1619 0.478907501941336 2087 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1708 st033234 31.827 µM 0.0527921662686227 0.486526424739818 no 1620 0.478948751605196 2293 674664
SGTC_3036 9090181 49.47 µM 0.051285156290049 0.487178165671425 no 1621 0.479549148051809 2311 25236586
SGTC_3183 9108214 49.47 µM 0.0500743483300086 0.487701832158841 no 1622 0.480031570577101 2304 4974831
SGTC_2276 7947513 42.08 µM 0.0500171096088426 0.487726588061655 no 1623 0.480054376945028 2090 2105100
SGTC_3129 9127257 49.47 µM 0.0495706446924102 0.487919686969747 no 1624 0.480232270001966 2188 837894
SGTC_140 0062-0056 502.533 µM 0.0485578143848094 0.488357752930213 no 1625 0.480635844762368 2316 3758964
SGTC_1174 0739-0097 51.1 µM 0.0478557047455831 0.488661435306653 no 1626 0.480915620703765 2262 728447
SGTC_2759 disulfiram 3.38 µM 0.047626910763424 0.488760396636087 no 1627 0.481006792336652 2299 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1142 3253-1408 9.78 µM 0.0472424503449714 0.48892669065133 no 1628 0.481159997395342 2331 256655
SGTC_1182 1222-0449 220 µM 0.0469887071019966 0.48903644548383 no 1629 0.481261114007492 2275 658318
SGTC_2889 9059656 51.95 µM 0.0462449173688157 0.489358171188216 no 1630 0.481557520932952 2290 3949838
SGTC_518 1021-0119 62.6 µM 0.0456298814331959 0.489624209771062 no 1631 0.481802626015448 2157 1097762
SGTC_1494 4358-1428 177 µM 0.0447962550543129 0.48998480869867 no 1632 0.482134855065941 2338 1564571
SGTC_1017 4239-0030 168 µM 0.0447221433136351 0.490016867362854 no 1633 0.482164391771232 2247 1149593
SGTC_538 2922-0838 53.3 µM 0.0447071292347121 0.490023362040925 no 1634 0.482170375537158 2324 777039
SGTC_3354 9151612 71.43 µM 0.0440670036157327 0.490300265236301 no 1635 0.482425497261257 2318 27261949
SGTC_849 0386-0493 241 µM 0.0440546567788535 0.490305606232153 no 1636 0.48243041815759 2236 726119
SGTC_3196 9111891 49.47 µM 0.0435078536368965 0.490542144115754 no 1637 0.482648352079453 2334 18891510
SGTC_2381 9035592 200 µM 0.0430489950582743 0.490740641223969 no 1638 0.482831238809926 2176 4749657
SGTC_863 0466-0191 129 µM 0.0426594389809239 0.490909160644073 no 1639 0.482986506559946 2337 765160 YPR165W RHO1
SGTC_1364 1653-0028 37.6 µM 0.0417382662491554 0.491307660365002 no 1640 0.483353674235986 2284 5718652
SGTC_2205 7238770 200 µM 0.0411642760631024 0.491555973179559 no 1641 0.483582466545769 2329 279867
SGTC_761 k216-0224 480 µM 0.0400723081131417 0.492028376334586 no 1642 0.484017739493512 2355 1340404
SGTC_3191 9110352 49.47 µM 0.0391748730159647 0.492416629802912 no 1643 0.484375483341343 2337 17122424
SGTC_2619 obliquin 87.91 µM 0.0386438619006707 0.492646362253938 no 1644 0.484587165826278 2318 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3280 9140961 49.47 µM 0.0377042187378897 0.493052887972437 no 1645 0.484961756161911 2314 4901226
SGTC_2688 kanamycin b 96.69 µM 0.037240216250359 0.493253635955677 no 1646 0.48514673645352 2307 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_354 2783-3500 4.88 µM 0.0354660400582638 0.49402123830344 no 1647 0.485854062718783 2313 6740761
SGTC_3319 9138450 16.7555 µM 0.035382091463548 0.494057559471291 no 1648 0.485887532356067 2233 2029690
SGTC_774 k060-0086 136 µM 0.0349677962821764 0.494236808986487 no 1649 0.486052710002463 2347 5911235
SGTC_1676 st018489 23.4 µM 0.0348249227504035 0.494298625114238 no 1650 0.486109673600549 2221 3696235
SGTC_2198 6589944 200 µM 0.0338017441535813 0.494741320811374 no 1651 0.486517622554194 2293 5290268
SGTC_2371 9071574 200 µM 0.0335898183404545 0.494833014962018 no 1652 0.486602120737724 2353 45596039
SGTC_1211 1056-0033 32.3 µM 0.0319741548192715 0.495532074314018 no 1653 0.487246330911164 2354 6741922
SGTC_551 k048-0028 34.9 µM 0.0318471713116443 0.495587017680705 no 1654 0.487296964214968 2347 6836383
SGTC_1512 0259-0544 12.2 µM 0.0314889442627922 0.495742016210266 no 1655 0.487439804487197 2272 18476
SGTC_1798 st045719 60.953 µM 0.0311118775969079 0.495905167003982 no 1656 0.487590158651646 2356 3980186
SGTC_2740 felodipine 17.08 µM 0.0306785708258283 0.496092652847447 no 1657 0.487762940560531 2359 3333 L-type calcium channel blocker
SGTC_301 4119-0100 24.5 µM 0.0297416966613375 0.496498028228816 no 1658 0.488136528745567 2343 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3161 9100388 49.47 µM 0.0294390872390835 0.49662896486615 no 1659 0.488257199597352 2332 25236368
SGTC_1470 k295-0292 231 µM 0.0291839012742596 0.49673938204174 no 1660 0.488358960343849 2348 5045612
SGTC_45 0kpi-0036 14.9 µM 0.0285516510161283 0.497012953348235 no 1661 0.488611086622996 2328 2795021
SGTC_460 trequinsin 123 µM 0.0279075067920341 0.497291672553964 no 1662 0.488867960611218 2362 5537 A vasodilator.
SGTC_2143 5623677 140.463 µM 0.0277600894685607 0.497355459762919 no 1663 0.488926748837734 2356 5375313
SGTC_103 0844-0104 51.839 µM 0.0270244928923346 0.497673752047575 no 1664 0.489220099330096 2359 5375804
SGTC_2621 lithochol-11-enic acid 100 µM 0.0257314393940845 0.498233259139488 no 1665 0.489735773571925 2363 6708711
SGTC_374 0880-0231 82.3 µM 0.0249390310391455 0.4985761377646 no 1666 0.490051797319775 2351 6833587
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0249338433436342 0.498578382507299 no 1667 0.49005386626749 2355 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0244188493212776 0.498801223298797 no 1668 0.490259256612015 2352 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1255 0566-0045 221 µM 0.02422502409155 0.498885092659506 no 1669 0.490336558823343 2325 2788469
SGTC_1179 1021-1431 9.29 µM 0.0241776595730351 0.498905587583584 no 1670 0.490355448999523 2331 2840958
SGTC_1790 st045711 43.5 µM 0.0240961388551104 0.498940862115998 no 1671 0.49038796158849 2359 585119
SGTC_2245 6637752 200 µM 0.0235879594698834 0.499160754739467 no 1672 0.490590638215832 2353 681890
SGTC_565 1418-0001 44.5 µM 0.023481608998591 0.499206773335158 no 1673 0.490633054166922 2359 2862145
SGTC_2185 6113692 200 µM 0.023060954136297 0.49938879374532 no 1674 0.490800825740998 2338 874150
SGTC_1847 st056231 15 µM 0.0222625527418422 0.499734268138685 no 1675 0.491119260028252 2353 5393180
SGTC_2899 9053889 58.44 µM 0.0218719595162527 0.499903280905179 no 1676 0.491275046243647 2373 6470052
SGTC_328 k915-0120 63.5 µM 0.0217939617368286 0.499937031161988 no 1677 0.491306155440208 2357 6624543
SGTC_1880 MG-132 525 µM 0.0216668125595005 0.499992049618751 no 1678 0.491356868647879 2362 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2679 rapamycin 1 nM 0.0216300654571616 0.499992049618751 no 1679 0.491371525185852 2359 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2771 fluoxetine 41.05 µM 0.0210473192059127 0.499739890714459 no 1680 0.491603954377779 2352 3386 A selective serotonin reuptake inhibitor.
SGTC_2515 chrysin 20.77 µM 0.0205179891539554 0.499510845508773 no 1681 0.491815080913652 2361 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2165 5727197 32.143 µM 0.0202273380901943 0.499385078610234 no 1682 0.491931009851039 2321 1361712
SGTC_76 0433-0009 400.328 µM 0.0200112348938653 0.499291569172824 no 1683 0.492017205105748 2253 2841569
SGTC_25 0118-0223 35.662 µM 0.0183700258972048 0.498581407646258 no 1684 0.492671832137817 2366 5333628
SGTC_3243 9134147 49.47 µM 0.0171990040424099 0.498074701690249 no 1685 0.49313892836575 2373 24282180
SGTC_1210 3013-0140 750 nM 0.0163894512835135 0.497724406660158 no 1686 0.493461847638404 2382 905973
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0154286796133356 0.497308681215884 no 1687 0.493845091562437 2387 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2349 9023730 187.07 µM 0.0154121059797323 0.49730150983686 no 1688 0.493851702699549 2368 4126287
SGTC_1431 4049-0260 9.09 µM 0.0152577835776774 0.497234734875817 no 1689 0.493913261191991 2375 3854841
SGTC_2462 5162487 171.77 µM 0.0146981483282257 0.496992582608432 no 1690 0.494136498309835 2377 2259986
SGTC_1524 corynanthine 62.1 µM 0.0136033315961331 0.496518862421764 no 1691 0.494573223243908 2316 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_150 3970-0969 77.2 µM 0.0134011925175339 0.496431398654303 no 1692 0.494653857718131 2333 6615640
SGTC_3128 9127691 49.47 µM 0.0133557506289731 0.496411736379902 no 1693 0.494671984786482 2362 41316314
SGTC_2471 5466956 24.79 µM 0.0129224066752878 0.496224233003885 no 1694 0.494844849088319 2324 724419
SGTC_1652 st011932 78 µM 0.0127659143426358 0.496156520618499 no 1695 0.49490727534679 2382 1551076
SGTC_2876 9059903 25.97 µM 0.0124519522432873 0.496020673259448 no 1696 0.495032518145878 2390 6916095
SGTC_1515 3460-0031 42.1 µM 0.0121902846745262 0.495907453422531 no 1697 0.495136900478729 2366 2876596
SGTC_1758 st042942 75.2445 µM 0.0119708147737928 0.495812492170467 no 1698 0.49522444991253 2387 669317
SGTC_1570 verbenone 133 µM 0.011879027829983 0.495772777441011 no 1699 0.495261065001698 2388 29025 A natural terpanoid with antifungal properties.
SGTC_2489 cantharidin 73.42 µM 0.0102612964487059 0.495072818411367 no 1700 0.49590640683361 2376 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1629 st005085 44.9 µM 0.00999953833838754 0.494959562440683 no 1701 0.496010827852497 2383 24207091
SGTC_629 3448-6466 76.7 µM 0.00971545521230525 0.494836647472558 no 1702 0.496124155116106 2383 573744
SGTC_2289 7946404 165.07 µM 0.00933758626019708 0.494673154714382 no 1703 0.496274896176279 2384 1246120 YPR165W RHO1
SGTC_284 0988-0104 32.6 µM 0.00920555598453418 0.494616029315123 no 1704 0.496327566371628 2369 4666532
SGTC_2272 7805186 180 µM 0.00856663828328954 0.494339591052391 no 1705 0.496582447588761 2386 2956062 YPR165W RHO1
SGTC_2842 9000675 19.48 µM 0.00833668553252359 0.494240098867046 no 1706 0.496674182186947 2379 2989072
SGTC_533 1222-0222 6.71 µM 0.00815335709458487 0.494160779581196 no 1707 0.496747317166024 2383 3982874
SGTC_2252 omeprazole 400 µM 0.00768181755199241 0.493956763311957 no 1708 0.496935428328436 2376 4594 A proton pump inhibitor.
SGTC_1862 st057513 3.81 µM 0.00694572521983521 0.493638288828822 no 1709 0.497229078821412 2396 5393163
SGTC_1206 3978-0017 132 µM 0.0066697360455404 0.493518881596223 no 1710 0.497339180020262 2367 3873677
SGTC_1458 k015-0034 6.33 µM 0.00662873246014421 0.493501141367577 no 1711 0.497355537722513 2376 3598957
SGTC_125 0133-0007 11.75 µM 0.00661888949860237 0.493496882805595 no 1712 0.497359464409894 2391 26541
SGTC_2627 acetyl isogambogic acid 100 µM 0.00653839160109206 0.493462055379892 no 1713 0.49739157772977 2382 6857789 A caspase activator and apoptosis inducer.
SGTC_745 0469-0705 296 µM 0.0065363666124916 0.493461179268956 no 1714 0.497392385566078 2394 3486736
SGTC_2612 dictamnine 15.46 µM 0.00628234502419568 0.493351277128139 no 1715 0.497493723436018 2378 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.00568637077696891 0.493093431568101 no 1716 0.497731478500404 2388 641818 YHR062C RPP1
SGTC_1496 4469-0713 57.4 µM 0.00519761545038299 0.4928819759375 no 1717 0.49792646077576 2394 746691
SGTC_2054 5233173 129 µM 0.00449090144305766 0.492576225981264 no 1718 0.498208395559489 2385 6889
SGTC_767 0929-0023 86 µM 0.00416460240703073 0.492435058716253 no 1719 0.498338568821395 2391 1204563
SGTC_1134 3477-0009 42.5 µM 0.00234184910123096 0.491646496013442 no 1720 0.499065738233154 2402 3973534
SGTC_2799 7812892 81.82 µM 0.00199294660019861 0.491495556834965 no 1721 0.499204929864913 2397 20205235
SGTC_3140 9094243 49.47 µM 0.00193961131802548 0.491472483493845 no 1722 0.499226207522874 2403 19291112
SGTC_400 oxethazaine 37.5 µM 0.00173953718590494 0.491385929810881 no 1723 0.499306025418205 2397 4621 A local anesthetic.
SGTC_2296 7971656 126.45 µM 0.000937683281427659 0.491039045456768 no 1724 0.499625918548231 2404 666570
SGTC_598 3937-0236 20.2 µM -0.000403328622113374 0.490458935044374 no 1725 0.499839095164105 2407 1379313
SGTC_950 1165-0508 94.1 µM -0.000676006288830433 0.490340979420164 no 1726 0.499730312530109 2402 6148369
SGTC_1977 st070720 65.3 µM -0.00104943636120359 0.490179441427231 no 1727 0.499581335541772 2413 682188
SGTC_2282 7944268 200 µM -0.00183906190644769 0.4898378713653 no 1728 0.499266320862811 2407 2970414
SGTC_790 1575-0012 79.1 µM -0.00241252846620484 0.489589810329252 no 1729 0.499037541325791 2410 378741 YLR208W SEC13
SGTC_3174 9107204 49.47 µM -0.0025608623263749 0.489525647080798 no 1730 0.498978364860372 2410 3938802
SGTC_3198 9112019 49.47 µM -0.00359941656143115 0.489076418069532 no 1731 0.498564043649529 2416 45595555
SGTC_3079 9117512 49.47 µM -0.00367978851820714 0.489041653566082 no 1732 0.49853198009019 2412 7185044
SGTC_2549 cedrol 20.94 µM -0.00409043979202839 0.488864029637195 no 1733 0.498368155172114 2414 6708665 A sedative which affects the nervous system.
SGTC_1 0258-0098 57.368 µM -0.00434817143963666 0.488752550997226 no 1734 0.498265336036395 2348 6790032 YDR047W HEM12
SGTC_622 1348-1566 26.3 µM -0.00453208487057468 0.488673002051601 no 1735 0.498191965916203 2410 7340407
SGTC_82 0054-0107 293.755 µM -0.00768654837567635 0.487308659836849 no 1736 0.496933541058567 2447 3104697
SGTC_560 2332-1943 155 µM -0.00818466510137152 0.487093231718445 no 1737 0.496734827495144 2418 21177716
SGTC_827 3253-0474 693 µM -0.00854497065486952 0.486937407237993 no 1738 0.496591091405476 2429 5402065
SGTC_1979 st071809 45.3 µM -0.0095535267422791 0.486501238883727 no 1739 0.496188752230997 2451 4976333
SGTC_1265 0819-1001 68.8 µM -0.0103001917047987 0.486178340464816 no 1740 0.49589089069145 2425 3106768
SGTC_668 1682-0499 62.6 µM -0.0109055694941665 0.485916548923162 no 1741 0.495649393474413 2435 682214
SGTC_1757 st041620 31.8375 µM -0.0110989744187024 0.485832913541977 no 1742 0.495572240742708 2438 5289815
SGTC_641 4092-0595 30 µM -0.0112377719341053 0.485772892790724 no 1743 0.495516871998693 2435 786260
SGTC_696 1560-0013 611 µM -0.0119583569532788 0.485461292609426 no 1744 0.49522941950814 2435 1650269
SGTC_828 2074-0507 139 µM -0.0119588575105193 0.485461076158188 no 1745 0.495229219828972 2447 X828
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0129284765345884 0.485041801083259 no 1746 0.494842427767078 2422 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2015 5119600 184 µM -0.0132344791660476 0.484909485229609 no 1747 0.494720360824755 2440 2828786
SGTC_44 0929-0055 61.211 µM -0.0147394170780608 0.484258772980072 no 1748 0.494120036243957 2416 1379590
SGTC_946 3434-1334 87.4 µM -0.0153937302199568 0.483975870908755 no 1749 0.493859032697485 2445 4047976
SGTC_1049 3226-0134 66 µM -0.0175135437828854 0.483059393944366 no 1750 0.493013464063797 2424 5702385
SGTC_1529 apigenin 74 µM -0.0184224571032032 0.482666462878018 no 1751 0.492650918652023 2441 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1408 3909-7976 48.8 µM -0.0200006735279986 0.481984226526298 no 1752 0.492021417638039 2452 24152374
SGTC_3139 9095020 49.47 µM -0.0205101438646615 0.481764002256976 no 1753 0.491818210072767 2434 25236292
SGTC_2508 celastrol 40.54 µM -0.0210175395554224 0.481544680307192 no 1754 0.491615832112028 2438 122724 Celastrol is a natural product and antioxidant.
SGTC_3163 9099914 49.47 µM -0.0232762116087106 0.480568437288844 no 1755 0.490714973479365 2444 16268368
SGTC_1679 SEC14.276 6.7 µM -0.0238626355220787 0.480314992020471 no 1756 0.4904810891619 2462 1005053 YMR079W SEC14
SGTC_3307 9126885 69.2785 µM -0.024625865078554 0.479985145441246 no 1757 0.490176694101926 2440 24824909
SGTC_899 1083-0020 478 µM -0.0249519773723271 0.479844212946935 no 1758 0.490046634086826 2463 767123
SGTC_2801 7907800 81.82 µM -0.0253170253218233 0.479686457032515 no 1759 0.489901047020287 2469 6620925
SGTC_2692 st077426 47.7 µM -0.0256296254781468 0.479551369023595 no 1760 0.48977637805638 2452 25238571
SGTC_2581 avocatin a 64 µM -0.0264343258365695 0.479203634137206 no 1761 0.489455457825436 2475 6710728 A skin care supplement.
SGTC_2630 antimycin a 100 µM -0.0274565617620608 0.478761918540941 no 1762 0.489047792732857 2441 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_272 doxorubicin 8.13 µM -0.0302462825862666 0.477556594146384 no 1763 0.487935318616791 2441 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2978 9011784 42.97 µM -0.0303222958925611 0.477523754725056 no 1764 0.487905007597928 2497 2994934
SGTC_2182 6325192 200 µM -0.0305107856907597 0.477442323642605 no 1765 0.487829845824713 2461 736248
SGTC_143 4032-1194 15.74 µM -0.0305533221048679 0.47742394725434 no 1766 0.487812884158399 2452 1806963
SGTC_3249 9135183 49.47 µM -0.0310145774204931 0.477224680920424 no 1767 0.487628957082606 2562 4902779
SGTC_1171 0368-0077 21.4 µM -0.0313983417333058 0.477058895715647 no 1768 0.487475931802906 2455 3239779
SGTC_964 1287-0107 19.4 µM -0.0315912265507663 0.476975571463733 no 1769 0.487399020048762 2472 51516812 YPR165W RHO1
SGTC_2028 5153890 36.43 µM -0.0318002437057387 0.476885279344944 no 1770 0.487315676143444 2461 2830968 YPR165W RHO1
SGTC_1406 3909-7906 11.9 µM -0.0332691437465668 0.476250771399321 no 1771 0.486729979927712 2479 X1406
SGTC_2555 cholic acid 100 µM -0.0333072246785431 0.476234322704911 no 1772 0.486714796248743 2581 6708657 Influences liver metabolism.
SGTC_3111 9122088 49.47 µM -0.0347870868586295 0.475595142026524 no 1773 0.486124758797185 2478 16876704
SGTC_149 3970-0822 46.1 µM -0.0353986789054834 0.475331002011561 no 1774 0.485880919066957 2466 3114250 YBL034C STU1
SGTC_338 4055-0136 114 µM -0.0369978802327034 0.474640375722203 no 1775 0.485243347957048 2462 2900563
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0371658560902892 0.474567838558304 no 1776 0.485176381343002 2487 689007
SGTC_410 α-linolenic acid 100 µM -0.0375432850201741 0.474404856166946 no 1777 0.485025914000898 2568 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.0375892440942049 0.474385010286084 no 1778 0.485007591915948 2485 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2404 5161160 200 µM -0.037837839445804 0.474277663844924 no 1779 0.484908487223664 2476 2831543
SGTC_1762 st045503 25.4615 µM -0.0395252068956011 0.473549088186007 no 1780 0.48423582850964 2505 4645554
SGTC_779 1360-0071 233 µM -0.0398110677978719 0.473425667160823 no 1781 0.484121876200538 2502 7566
SGTC_156 3474-0145 5.642 µM -0.0398445710228633 0.473411202242161 no 1782 0.484108520944184 2464 2265471
SGTC_2141 5621638 7.665 µM -0.0399707034528069 0.473356745251828 no 1783 0.484058241438989 2540 2856238
SGTC_2544 sphondin 68.51 µM -0.041955762997688 0.47249977283215 no 1784 0.483266981527507 2486 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2853 9015042 58.44 µM -0.0423766893328271 0.4723180704457 no 1785 0.483099205435201 2486 6457456
SGTC_3112 9123419 49.47 µM -0.0429078063511729 0.472088809979985 no 1786 0.482887512957452 2486 17015854
SGTC_1445 4239-0156 97.7 µM -0.0433870294771719 0.471881957818751 no 1787 0.482696508471842 2555 4008346
SGTC_1302 1159-0335 255 µM -0.0436156807289965 0.471783265322692 no 1788 0.482605376089025 2489 649284
SGTC_3281 9140613 49.47 µM -0.0440999723801381 0.471574236762188 no 1789 0.482412357401108 2509 16013766
SGTC_1292 0kpi-0043 232 µM -0.0453575675171204 0.471031473898244 no 1790 0.481911151185517 2505 3333905
SGTC_2302 7771753 200 µM -0.0456015128925501 0.47092619622148 no 1791 0.48181393165728 2523 2203047
SGTC_57 miconazole 162.5 nM -0.0459574560517465 0.470772588148069 no 1792 0.481672079604327 2461 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2782 7736369 71.43 µM -0.0461818039977734 0.470675772518543 no 1793 0.481582672652825 2501 2950836 YOL077C BRX1
SGTC_3154 9100113 49.47 µM -0.0462278199835198 0.470655914888057 no 1794 0.481564334515892 2498 25237525
SGTC_2670 beta-carotene 100 µM -0.046287932704308 0.470629974095543 no 1795 0.48154037865397 2497 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.0476510462058457 0.470041775455024 no 1796 0.480997174607993 2518 688801
SGTC_716 1683-5115 658 µM -0.0476894698747057 0.470025196155645 no 1797 0.480981863189049 2484 723597
SGTC_695 3505-6186 243 µM -0.0478911830170217 0.46993816048481 no 1798 0.480901483131255 2538 1819379
SGTC_2639 lactacystin 53 µM -0.0479646026564544 0.469906481558857 no 1799 0.480872226554575 2515 3870 A proteasome inhibitor.
SGTC_958 1222-0007 33 µM -0.0493487616731119 0.469309283889087 no 1800 0.48032068031592 2548 7312461
SGTC_1806 st050005 60.3 µM -0.0504108913675983 0.468851073039987 no 1801 0.479897478683198 2516 5194765
SGTC_3115 9123671 49.47 µM -0.0509085250963322 0.468636404210796 no 1802 0.479699206137933 2494 3286988
SGTC_914 3820-6779 408 µM -0.0513030911008366 0.468466203129907 no 1803 0.47954200250396 2504 2893481
SGTC_1489 4065-0444 182 µM -0.0514864469298335 0.468387112212914 no 1804 0.479468950655647 2486 2877968
SGTC_1392 3455-1037 33.9 µM -0.0517808716796771 0.468260114098276 no 1805 0.479351648644846 2572 981132
SGTC_847 0342-0274 5.54 µM -0.0521322304119488 0.468108562125693 no 1806 0.479211665859829 2500 18097
SGTC_3286 9117135 37.221 µM -0.052159250668287 0.468096907638056 no 1807 0.479200900982913 2535 3438150
SGTC_916 4466-0038 42 nM -0.0536706915007179 0.467445030620803 no 1808 0.478598766963999 2505 5722064 YGL116W CDC20
SGTC_1011 4112-3381 17.4 µM -0.0537084535101673 0.467428745161885 no 1809 0.478583723798959 2642 2877139
SGTC_2997 9067075 71.4286 µM -0.0540794387273991 0.46726875487065 no 1810 0.478435936894948 2553 27209819
SGTC_375 3970-0961 9.27 µM -0.0552776787952163 0.466752040673254 no 1811 0.477958622356244 2533 2898222
SGTC_2397 5161689 200 µM -0.0556303983302569 0.466599948907261 no 1812 0.477818123814557 2546 2259942
SGTC_794 k038-0031 316 µM -0.0556946050984395 0.466572263636248 no 1813 0.477792548670664 2491 6624242
SGTC_418 lividomycin a 100 µM -0.0565806035432312 0.46619024716582 no 1814 0.477439642959465 2507 72394 An antibiotic.
SGTC_1769 st044406 64.4 µM -0.0570628997601924 0.465982308292791 no 1815 0.477247544973636 2514 670903
SGTC_470 aa-861 153 µM -0.0579025735076532 0.465620310615687 no 1816 0.476913116600495 2521 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2950 9072895 21.46 µM -0.0581487997115 0.465514163679062 no 1817 0.476815051787675 2549 17332245
SGTC_2109 5483026 200 µM -0.0583169023702775 0.465441696837251 no 1818 0.476748102141307 2544 759335
SGTC_1238 0333-0287 48.8 µM -0.0585626950149338 0.465335740929411 no 1819 0.476650212363266 2520 7226
SGTC_1137 ixabepilone 100 µM -0.0591500682809694 0.465082546950341 no 1820 0.476416289849913 2507 154225 A novel microtubule stabilizer.
SGTC_3160 9100216 49.47 µM -0.0592952496062872 0.4650199670508 no 1821 0.476358472362238 2502 17191039
SGTC_2111 5486399 200 µM -0.0593927443356912 0.464977942776144 no 1822 0.476319646020363 2497 689674
SGTC_1650 st011916 45.8 µM -0.059995703540353 0.464718051030684 no 1823 0.476079528303027 2523 242528
SGTC_1557 sumaresinolic acid 42.3 µM -0.0603394972813624 0.464569873348618 no 1824 0.475942622478221 2490 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1161 k007-0610 110 µM -0.0626512330487662 0.463573626500921 no 1825 0.475022115721607 2520 5843850
SGTC_1089 terbinafine 2.25 µM -0.0632703881896467 0.463306838953189 no 1826 0.474775597652909 2556 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_558 k064-0027 21.3 µM -0.0632993401529972 0.463294364254486 no 1827 0.474764070596536 2570 5088526
SGTC_2017 5132927 60.65 µM -0.064519614568611 0.462768610582088 no 1828 0.47427824474106 2552 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1941 st076221 61.8 µM -0.0655754539423964 0.462313755982013 no 1829 0.473857915978017 2586 2828568
SGTC_562 3772-2733 112 µM -0.0661223988026471 0.462078151993147 no 1830 0.473640189103687 2536 2876874 YIL048W NEO1
SGTC_1558 st069300 45.6 µM -0.0661453508068823 0.462068265393318 no 1831 0.473631052580797 2523 24208000
SGTC_2711 st079103 59.1 µM -0.0662792319202158 0.462010596431001 no 1832 0.473577758694312 2589 54693780
SGTC_2796 7949634 45.45 µM -0.0678156301303498 0.46134885412992 no 1833 0.472966200680849 2518 2971588
SGTC_1273 0849-0096 14.1 µM -0.0679731003327987 0.461281036130165 no 1834 0.472903523784972 2553 5286025
SGTC_1016 4226-1401 38 µM -0.0679745165827242 0.461280426196149 no 1835 0.472902960086769 2522 2901613
SGTC_2307 7538926 6.34 µM -0.0705268269929455 0.460181376259409 no 1836 0.471887174428041 2570 96582
SGTC_2233 sulbentine 40.3845 µM -0.0706780820464998 0.460116253811412 no 1837 0.471826982598521 2519 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2475 5812728 15.03 µM -0.0719603275767389 0.459564229671439 no 1838 0.471316739985433 2520 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3257 9139206 32.98 µM -0.0726967947169168 0.459247205723822 no 1839 0.471023699623768 2552 4910041
SGTC_1690 st023502 41.2 µM -0.0731482211740211 0.459052894850967 no 1840 0.470844084728871 2540 24207482
SGTC_1203 3992-3522 103 µM -0.0737646702808377 0.458787567851142 no 1841 0.470598819720267 2614 5322312
SGTC_778 3456-2434 196 µM -0.0748756213827949 0.458309447768383 no 1842 0.470156836707075 2706 5539063
SGTC_294 k038-0071 157 µM -0.0752041754379564 0.458168059467984 no 1843 0.470026131122878 2586 24152826
SGTC_2742 clothiapine 36.27 µM -0.075530304814328 0.458027719826068 no 1844 0.469896393319769 2532 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_111 0083-0039 52.457 µM -0.0757140499596978 0.457948653116416 no 1845 0.469823298914645 2526 759313
SGTC_1753 st043925 64 µM -0.0763772772014233 0.45766327606386 no 1846 0.469559473478884 2547 670181
SGTC_646 4092-0839 27.3 µM -0.0768920730575635 0.457441781919467 no 1847 0.469354701831037 2600 877796
SGTC_1306 1185-0270 9.02 µM -0.0770655486796861 0.457367145919724 no 1848 0.469285699817911 2564 1548076
SGTC_276 colchicine 750 µM -0.0772968317539845 0.457267641231474 no 1849 0.469193705631242 2653 2833 A microtubule depolymerizer.
SGTC_2594 a-mangostin 100 µM -0.0776354741521285 0.457121952281941 no 1850 0.469059011617974 2634 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2536 dehydroabietamide 32.04 µM -0.0780553075329522 0.456941341777916 no 1851 0.468892029049379 2601 3983547
SGTC_2423 st077119 87.2 µM -0.0781781151343 0.456888512158788 no 1852 0.468843185160551 2503 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3039 9090270 49.47 µM -0.0789004284762971 0.456577801413584 no 1853 0.46855591121546 2551 17173750
SGTC_2457 5731572 11.68 µM -0.0790149102634032 0.456528558290929 no 1854 0.468510381734231 2546 2865357
SGTC_2323 6148992 148.28 µM -0.081735436367863 0.455358551045135 no 1855 0.467428549238563 2609 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_755 1995-0008 37.3 µM -0.0818346394286755 0.45531589438164 no 1856 0.467389105081005 2541 689533
SGTC_3201 9113999 49.47 µM -0.0826292114537882 0.454974252267288 no 1857 0.46707318665573 2720 16649224
SGTC_1486 3970-0793 4.53 µM -0.0827916216825832 0.454904424835857 no 1858 0.467008615592673 2641 2844330
SGTC_567 1080-0542 68.4 µM -0.0842452297859597 0.454279515905271 no 1859 0.466430728904974 2554 5950415
SGTC_773 4358-1457 44.6 µM -0.0843864408165797 0.454218815015976 no 1860 0.466374593746417 2548 1186886
SGTC_1419 3993-2473 62.6 µM -0.0844354406580851 0.454197752223182 no 1861 0.466355115156161 2569 704026
SGTC_144 4161-2749 112.381 µM -0.08451803127957 0.454162250580567 no 1862 0.466322283622693 2544 797501 YMR168C CEP3
SGTC_1096 rimcazole 32.2 µM -0.0847621050871552 0.454057337406658 no 1863 0.466225260418982 2550 18528119 A dopamine reuptake inhibitor.
SGTC_2136 5328288 199.296 µM -0.0853857703563898 0.453789274456487 no 1864 0.465977352728717 2571 262395
SGTC_2431 5490079 200 µM -0.0869657472000422 0.453110265469959 no 1865 0.465349369347649 2599 5722345
SGTC_2885 9057732 51.95 µM -0.088344720094669 0.452517751656793 no 1866 0.46480134819279 2661 6471414
SGTC_2496 diffractaic acid 79.83 µM -0.0885573245660522 0.452426409643494 no 1867 0.464716862418309 2582 94870 An apoptosis inducer which activates caspases.
SGTC_1923 st058458 19.1 µM -0.0887649321245591 0.452337216901237 no 1868 0.464634363875786 2604 3534982
SGTC_2772 vinpocetine 57.06 µM -0.0905840913660183 0.451555769721908 no 1869 0.463911536603766 2640 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3168 9103419 49.47 µM -0.0914896943854488 0.45116682412237 no 1870 0.463551747291438 2562 16649256
SGTC_1347 1493-0251 600 nM -0.0919952000314577 0.4509497358939 no 1871 0.463350926620491 2637 3986378
SGTC_924 2046-0044 21.3 µM -0.0922400765968222 0.450844579491137 no 1872 0.463253648616149 2559 3623589
SGTC_2820 7989630 71.43 µM -0.0931319722347337 0.450461605394756 no 1873 0.462899358819708 2563 2984098
SGTC_2057 5236571 38.335 µM -0.0931958386101073 0.450434183360321 no 1874 0.462873990155345 2605 54684039 YBR257W POP4
SGTC_2858 9025781 8.96 µM -0.0933823534382871 0.450354101635442 no 1875 0.462799904584994 2642 4894980 YPL153C RAD53
SGTC_2582 agaric acid 100 µM -0.0942950948762232 0.449962237559231 no 1876 0.462437373138569 2573 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_771 0250-0039 27.3 µM -0.0948366897888254 0.44972973955457 no 1877 0.462222271978598 2564 3005115
SGTC_2721 ifenprodil 61.44 µM -0.0951234506254342 0.449606644710986 no 1878 0.462108385812905 2629 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1290 0986-0249 10.2 µM -0.095219684825987 0.449565336342149 no 1879 0.462070167398102 2592 53329
SGTC_937 3122-0005 46.7 µM -0.0965270701169069 0.449004197736991 no 1880 0.46155098773006 2590 759535
SGTC_2348 9022543 33.42 µM -0.0989937697586149 0.447945752197712 no 1881 0.460571608409612 2678 3162678 YDL140C RPO21
SGTC_2119 5528445 120.635 µM -0.099314130158995 0.447808314558716 no 1882 0.460444429819132 2681 791935
SGTC_706 4262-0057 46.9 µM -0.100605304190284 0.447254452379718 no 1883 0.4599318929692 2567 883298
SGTC_2769 toremifene 3.73 µM -0.100624342848905 0.447246286321046 no 1884 0.459924335991223 2700 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2680 butyl paraben 22.24 µM -0.10063336053266 0.447242418465254 no 1885 0.459920756624488 2576 7184 An antifungal and steroid mimetic.
SGTC_2014 4013930 200 µM -0.100940261156605 0.447110785953736 no 1886 0.459798941263115 2572 64556
SGTC_613 3914-0030 117 µM -0.100983861973399 0.447092085633112 no 1887 0.45978163548083 2537 1145395
SGTC_2038 4100038 30.985 µM -0.101126005998249 0.447031121105148 no 1888 0.459725217031589 2668 3596803
SGTC_296 1222-0039 74.9 µM -0.102307937265291 0.446524248075073 no 1889 0.459256127671003 2622 5984176
SGTC_2786 7743617 45.45 µM -0.102778137398047 0.446322626272701 no 1890 0.459069528594585 2627 583674
SGTC_3033 9090887 49.47 µM -0.102830185700022 0.44630030881454 no 1891 0.459048873762518 2598 19325384
SGTC_2922 7999257 32.47 µM -0.103661214296001 0.445944000470928 no 1892 0.45871910364213 2588 2988377
SGTC_1318 1280-3875 124 µM -0.104752372540045 0.445476226354133 no 1893 0.458286151623625 2646 373245
SGTC_1785 bathophenanthroline 24 µM -0.1052146888771 0.44527805649065 no 1894 0.458102727689039 2609 72812 An iron chelator.
SGTC_2338 7999974 200 µM -0.105492628223706 0.445158925590629 no 1895 0.457992459588382 2690 315925
SGTC_1033 k072-0102 21.3 µM -0.106792815304805 0.444601702835062 no 1896 0.45747667371768 2584 5965931
SGTC_2210 7115885 190.385 µM -0.107799347173939 0.444170407364323 no 1897 0.457077430376576 2596 2927039
SGTC_1417 3966-0327 90.4 µM -0.107976034059549 0.444094704443087 no 1898 0.457007351546891 2622 651118
SGTC_2284 7945075 39.21 µM -0.10819612481258 0.44400040763793 no 1899 0.456920059431755 2692 1245402
SGTC_2610 ononetin 44.17 µM -0.108402577385281 0.443911956925845 no 1900 0.456838178363755 2681 259632
SGTC_990 3985-0011 41.3 µM -0.108615005436004 0.443820949049196 no 1901 0.456753929276768 2680 5399565 YGL099W LSG1
SGTC_1861 st057647 17.4 µM -0.108622805444319 0.443817607446145 no 1902 0.456750835825962 2794 688668
SGTC_3321 9137793 26.8275 µM -0.109728157098752 0.443344104036819 no 1903 0.45631248455552 2600 4904192
SGTC_2514 salinomycin 42.74 µM -0.109973769067102 0.44323890132657 no 1904 0.456215088981005 2709 23682228 A polyether potassium ionophore.
SGTC_217 ketoconazole 989 nM -0.11080053557116 0.442884802762911 no 1905 0.455887260321874 2641 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2584 androsterone 48.74 µM -0.110807956247827 0.442881624742854 no 1906 0.455884318017943 2633 2754130 A steroid.
SGTC_1155 4088-0394 48.2 µM -0.111871016930687 0.442426390562377 no 1907 0.455462838727693 2589 2326248
SGTC_689 0833-0039 98 µM -0.1119500844524 0.442392534529197 no 1908 0.455431492257303 2671 5374726
SGTC_2597 laccaic acid a 100 µM -0.111950551322205 0.442392334620809 no 1909 0.455431307166698 2695 5491415 A textile dye.
SGTC_2629 bisabolol 100 µM -0.112284327766196 0.442249419066615 no 1910 0.455298983923453 2699 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3023 9089636 49.47 µM -0.114295874064407 0.441388280044106 no 1911 0.45450162654349 2589 17249241
SGTC_2718 lomofungin 53.02 µM -0.114700176041662 0.441215232463224 no 1912 0.454341387194537 2705 5351222 A RNA synthesis inhibitor.
SGTC_2382 9035899 200 µM -0.114735129519479 0.441200272353641 no 1913 0.454327534228432 2630 6462679
SGTC_2568 diosmetin 100 µM -0.115178440788086 0.441010542150297 no 1914 0.45415184334816 2603 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_455 paf C-16 10 µM -0.115945492325378 0.440682288241775 no 1915 0.453847870570264 2609 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_911 3456-4043 236 µM -0.115983245149448 0.440666133256501 no 1916 0.453832910302336 2696 914281
SGTC_369 0957-0393 4.5 µM -0.116613844097443 0.440396305369972 no 1917 0.453583033288151 2655 6997992
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.116861283941452 0.440290435534375 no 1918 0.453484989408224 2587 6708630 An antioxidant.
SGTC_697 0508-1955 564 µM -0.117378920160892 0.440068973047034 no 1919 0.453279893931034 2624 6243113
SGTC_1451 4152-0210 104 µM -0.11842661326699 0.439620791534014 no 1920 0.452864819907288 2600 659563
SGTC_2921 7974240 10.71 µM -0.119328895602176 0.439234875739181 no 1921 0.452507395834998 2726 2979074 YDR527W RBA50
SGTC_1854 st056233 32.9 µM -0.11940162750037 0.439203770039457 no 1922 0.452478585980844 2602 5393174
SGTC_1402 3909-7673 35.9 µM -0.120612025476421 0.438686166921619 no 1923 0.451999171715716 2599 5328014
SGTC_1899 st063254 59.6 µM -0.12195490820328 0.438112032001062 no 1924 0.4514673648314 2605 3093813
SGTC_1019 4262-0212 3.4 µM -0.122014119225368 0.438086719960983 no 1925 0.451443918147712 2613 4677213
SGTC_246 cycloheximide 667 µM -0.122947382142079 0.437687794180194 no 1926 0.451074382348159 2611 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_117 lucigenin 22.078 µM -0.123932955224028 0.437266577035053 no 1927 0.450684179795384 2648 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1831 st055328 12 µM -0.124305273575825 0.437107472990364 no 1928 0.450536785989478 2654 1103068
SGTC_2821 7996764 71.43 µM -0.124371614367619 0.437079124425141 no 1929 0.450510523637993 2747 2987135
SGTC_3162 9099653 49.47 µM -0.125134076101228 0.436753334597616 no 1930 0.450208703240993 2631 25237511
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.12559033076949 0.436558403502885 no 1931 0.450028108638522 2651 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3119 9125183 49.47 µM -0.12619808257609 0.436298770423478 no 1932 0.449787564557504 2614 22695334
SGTC_855 0428-0020 25 µM -0.126747623401726 0.436064028843305 no 1933 0.449570075871631 2650 6812414
SGTC_188 3229-0966 278.469 µM -0.126876550906245 0.436008959494324 no 1934 0.449519053148795 2657 5722370
SGTC_981 1488-1094 54.9 µM -0.127265156020492 0.435842980461417 no 1935 0.449365268743296 2618 3449522
SGTC_2811 7967822 32.47 µM -0.127307666453994 0.435824824307156 no 1936 0.449348446364159 2735 2232244
SGTC_1895 st058434 18.3 µM -0.127636875170723 0.435684224248356 no 1937 0.44921817381088 2650 5393175
SGTC_2377 9073351 62.6 µM -0.127819400190309 0.43560627407762 no 1938 0.449145948432583 2627 7337946 YHR072W ERG7
SGTC_1666 st014829 29 µM -0.128392069448874 0.435361722945971 no 1939 0.448919353439256 2607 3858230
SGTC_139 0099-0334 718.624 µM -0.129264565940477 0.434989181953942 no 1940 0.448574154218835 2633 97690
SGTC_1606 st000094 49.2 µM -0.130240592915557 0.434572503621861 no 1941 0.448188039784989 2631 1242210
SGTC_2929 9013348 24.6 µM -0.130291091432983 0.434550947135494 no 1942 0.448168063998794 2726 2995952
SGTC_846 0335-0850 148 µM -0.130927078690551 0.434279477612055 no 1943 0.447916496682852 2649 6819598
SGTC_54 0159-0055 9 µM -0.131037516959096 0.434232340475697 no 1944 0.447872814513525 2705 3319099
SGTC_2831 7999036 19.48 µM -0.132337533872706 0.433677539199346 no 1945 0.447358660350137 2910 2988270
SGTC_2321 7390090 138.78 µM -0.133587268633525 0.433144319716958 no 1946 0.446864476052758 2720 649046
SGTC_1322 1348-1070 12 µM -0.134109497764171 0.432921538233295 no 1947 0.446657994680786 2638 6758089
SGTC_2583 asiatic acid 100 µM -0.134128636078832 0.432913374286403 no 1948 0.446650427959655 2773 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_553 k007-0256 45.7 µM -0.135604722838505 0.432283797540671 no 1949 0.446066885830006 2699 6287000
SGTC_1648 st011736 69.8 µM -0.135814014798843 0.432194544747752 no 1950 0.445984155757867 2774 2855514
SGTC_2428 5615643 7.78 µM -0.136190051640619 0.432034192108518 no 1951 0.445835519766417 2731 2253075
SGTC_3352 9151559 45.5865 µM -0.137236527090113 0.431588004688404 no 1952 0.445421919799894 2712 17159339
SGTC_1723 st034307 2.5525 µM -0.138855495675117 0.430897894589562 no 1953 0.444782169746452 2727 867466
SGTC_1015 4130-4525 82 µM -0.138996891515569 0.430837632437718 no 1954 0.444726302707763 2674 1363237
SGTC_2251 lansoprazole 556 µM -0.139025109663383 0.430825606206574 no 1955 0.444715153541192 2660 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_361 000s-0510 1.45 µM -0.139462648880171 0.430639140533034 no 1956 0.444542284664284 2734 660
SGTC_2968 9090663 33.37 µM -0.140389404549469 0.430244237059998 no 1957 0.44417616444603 2755 25236811
SGTC_1031 k035-0009 16 µM -0.141559620200497 0.429745691608501 no 1958 0.44371393202878 2862 5180959
SGTC_1173 0443-0020 122 µM -0.142138153690718 0.429499261063809 no 1959 0.443485440911346 2686 5331295
SGTC_726 3448-4391 34.2 µM -0.143097447894177 0.4290907033083 no 1960 0.443106610242948 2811 1356692
SGTC_951 1171-0579 82.7 µM -0.145102482375924 0.428237016705854 no 1961 0.442314979190614 2631 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_79 0052-0007 94.094 µM -0.145364895799665 0.428125313300814 no 1962 0.442211389660393 2799 2801472
SGTC_419 nsc-638432 893 µM -0.145928212709893 0.42788554161224 no 1963 0.441989029733824 2725 368090
SGTC_469 w7 172 µM -0.146117242297489 0.42780508852454 no 1964 0.441914417558812 2657 45115570 A P450 inhibitor.
SGTC_113 0099-0221 2.5 µM -0.149341285287075 0.426433364947599 no 1965 0.440642169788095 2677 89219
SGTC_444 curcumin 90.4 µM -0.149420145143336 0.426399823765619 no 1966 0.44061105832084 2791 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1005 4092-0690 4.4 µM -0.151216198898683 0.425636059201697 no 1967 0.439902586179305 2725 1529343
SGTC_2451 5856223 45.7 µM -0.151248640180295 0.425622266234527 no 1968 0.439889791139507 2711 2179896
SGTC_662 k832-1615 104 µM -0.152752728276561 0.424982877593118 no 1969 0.439296638749084 2750 5878478
SGTC_1341 1486-1360 280 µM -0.153661003143899 0.424596864901456 no 1970 0.438938517250085 2665 3976547
SGTC_141 0443-0274 32.331 µM -0.154322989805085 0.424315569110017 no 1971 0.438677535602796 2772 1627241
SGTC_1705 st027868 56.3335 µM -0.155008910048122 0.424024143965981 no 1972 0.438407146504393 2758 292948
SGTC_710 3448-4187 58 µM -0.155835317328345 0.423673085648988 no 1973 0.438081415744692 2692 3946412
SGTC_1471 k673-0312 37 µM -0.156604219815095 0.423346509793093 no 1974 0.437778388326374 2686 24099884
SGTC_2642 cholecalciferol 100 µM -0.15692613799596 0.423209797149247 no 1975 0.437651529962567 2766 9821465 A vitamin D precursor, similar to steriods.
SGTC_109 0132-0036 33.701 µM -0.157242457666331 0.423075471093919 no 1976 0.437526884047057 2654 67274 A color developer.
SGTC_36 0335-0881 14.2 µM -0.158738446099549 0.422440316716596 no 1977 0.436937473295817 2671 23828853
SGTC_809 3998-0021 90 µM -0.162118075103838 0.421006166518731 no 1978 0.43560643630449 2697 715485
SGTC_2418 pentamidine 31.67 µM -0.163669997365486 0.420347955998428 no 1979 0.434995468816916 2666 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1859 st055998 20 µM -0.164699913431534 0.419911264663197 no 1980 0.434590092561061 2701 676301
SGTC_96 0929-0093 37.281 µM -0.165503293737788 0.41957069443147 no 1981 0.434273928778201 2684 6991579
SGTC_2603 homopterocarpin 100 µM -0.16587051452573 0.419415041667029 no 1982 0.434129426011309 2814 101795 A weak amylase inhibitor.
SGTC_157 1348-1695 65.819 µM -0.166063000276009 0.419333458349692 no 1983 0.434053685656314 2701 5380510
SGTC_994 3910-0338 138 µM -0.167993124164481 0.418515585359199 no 1984 0.433294344164253 2855 3479481
SGTC_566 0958-0068 16.5 µM -0.168179926912663 0.418436447974098 no 1985 0.433220866008388 2854 6815365
SGTC_2175 5807670 165.306 µM -0.169557450630638 0.417852973981032 no 1986 0.432679093692404 2757 241186
SGTC_1221 2958-7315 257 µM -0.169948292160411 0.417687459158523 no 1987 0.432525400920049 2798 4562705
SGTC_1874 staurosporine 7.6 µM -0.170044695308091 0.417646636285488 no 1988 0.43248749334673 2827 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.170177423228233 0.41759043277797 no 1989 0.432435303190481 2700 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2464 5717415 7.67 µM -0.171883565523982 0.416868118791404 no 1990 0.431764533551763 2715 5285744
SGTC_635 k038-0028 24.7 µM -0.172511663040319 0.416602277364879 no 1991 0.431517646518483 2736 4035102
SGTC_2848 9016370 25.97 µM -0.173012632581536 0.416390270016415 no 1992 0.431320749000508 2743 7894410
SGTC_1307 1187-1599 12.2 µM -0.173103052877914 0.416352007270783 no 1993 0.431285212664673 2708 1538471
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.174143438823399 0.415911809000666 no 1994 0.43087636773789 2709 442882
SGTC_1071 trifluoperazine 6.31 µM -0.17531669490667 0.415415518543182 no 1995 0.430415397144282 2842 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2131 toluylene red 5.2905 µM -0.176724002424466 0.414820401728492 no 1996 0.429862593203471 2754 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2328 6201408 200 µM -0.177397799448963 0.414535538122183 no 1997 0.429597967845524 2823 2890418
SGTC_2244 6635614 200 µM -0.177624938167356 0.414439519985704 no 1998 0.429508769075835 2685 836499
SGTC_209 4077-0173 175.592 µM -0.177797078967199 0.414366754472883 no 1999 0.429441170723434 2816 15993494
SGTC_1234 0326-0494 15.5 µM -0.178632576726468 0.414013623613403 no 2000 0.429113106680449 2866 1547813
SGTC_1136 pergolide 1.05886 µM -0.178882998434283 0.413907794087994 no 2001 0.429014786370375 2733 47811 A dopamine receptor agonist.
SGTC_1743 st037606 46.3785 µM -0.179698229075018 0.413563316693049 no 2002 0.428694741903259 2750 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_67 0335-0847 266 µM -0.180176683856478 0.413361175591809 no 2003 0.428506931226057 3113 4552207 YOR254C SEC63
SGTC_230 MPP+ 141.667 µM -0.180414816255701 0.413260576216411 no 2004 0.428413461742494 2755 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3308 9128332 17.569 µM -0.180467026415959 0.413238520719836 no 2005 0.428392969239318 2872 17332805 YDL196W YDL196W
SGTC_421 streptovitacin 30 mM -0.181889782260895 0.412637601816288 no 2006 0.427834611658045 2923 91467 include heat shock
SGTC_1415 3966-0071 78.1 µM -0.182721828792821 0.41228627121917 no 2007 0.427508143603241 2744 2893185
SGTC_2567 aureobasidin a 60 nM -0.184038891614491 0.411730286878133 no 2008 0.426991472442257 3000 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1100 amiodarone 5.07 µM -0.185708299540515 0.411025818460055 no 2009 0.426336759725727 2839 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1380 2291-0730 164 µM -0.186664735137628 0.410622344183879 no 2010 0.425961753669727 2818 2999191
SGTC_876 0720-0963 56.8 µM -0.188342348943128 0.409914868075415 no 2011 0.425304144838336 2941 765861
SGTC_1779 st039427 55 µM -0.190331081968817 0.409076568013783 no 2012 0.424524849455208 2750 1124498
SGTC_2492 derrusnin 100 µM -0.191879601692164 0.408424116363935 no 2013 0.423918258016798 2701 1715307 Part of coumarin class of compounds.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.192012602551224 0.408368089732073 no 2014 0.423866166849523 2741 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2030 5175110 200 µM -0.192318808891937 0.408239107386886 no 2015 0.423746243015527 2875 2831986
SGTC_15 0266-0086 27.098 µM -0.193273546199798 0.407837010240404 no 2016 0.423372371394378 2808 1712902 YIL048W NEO1
SGTC_685 1278-0033 54.9 µM -0.19363976652068 0.407682798628876 no 2017 0.423228979149782 2867 3590572
SGTC_2512 diallyl trisulfide 49.23 µM -0.194115629487804 0.407482438997205 no 2018 0.423042671916022 2733 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_883 0850-0245 24.6 µM -0.195257517338766 0.40700175185091 no 2019 0.422595676578069 2955 6823229 YPR165W RHO1
SGTC_998 3996-0085 177 µM -0.195503055160283 0.406898408942218 no 2020 0.422499573078545 2829 715391
SGTC_1730 st033808 45.1 µM -0.197035692502318 0.406253493388079 no 2021 0.421899803333962 2748 1045166
SGTC_137 0438-0332 85.389 µM -0.197075605885289 0.406236701700931 no 2022 0.421884186371158 2743 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2068 5226020 147 µM -0.197873895987904 0.405900894773165 no 2023 0.421571864163697 2797 1810509
SGTC_1627 st003713 25.6 µM -0.19817064222264 0.405776083802424 no 2024 0.421455778035645 2830 16195070 YER133W GLC7
SGTC_3073 9114972 49.47 µM -0.198932406110435 0.405455731062747 no 2025 0.421157809844754 2860 41905075
SGTC_1101 ebselen 5.29 µM -0.199019109155005 0.405419272911104 no 2026 0.421123898324412 2899 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.199143991107621 0.405366762181629 no 2027 0.421075055198692 2740 16486 A toxic proline analog.
SGTC_2310 7668677 200 µM -0.199167760110042 0.405356767914743 no 2028 0.421065758937956 2953 2197143
SGTC_2365 9042475 200 µM -0.199282901293207 0.40530835482074 no 2029 0.421020726856584 2846 6464479
SGTC_1888 azatryptophan 97.5 µM -0.199316199826131 0.405294354148989 no 2030 0.4210077038875 2866 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1996 st072960 66.8 µM -0.199714331453562 0.405126965468215 no 2031 0.420852002348585 2751 1719405
SGTC_392 N-ethylmaleimide 8.33 µM -0.199920060082127 0.405040476642574 no 2032 0.420771550731598 2812 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_534 k292-0788 63.4 µM -0.199922784240779 0.405039331430624 no 2033 0.420770485452521 2778 4146317
SGTC_582 0987-0078 156 µM -0.200716582370953 0.404705660473339 no 2034 0.420460096362786 2779 1625765
SGTC_2607 solasodine 47.35 µM -0.200754929927109 0.404689542931355 no 2035 0.420445103041627 2794 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1395 3486-0190 4.35 µM -0.202668808886888 0.403885342387318 no 2036 0.419696952054644 2873 6748079
SGTC_1026 k007-1105 30.6 µM -0.203084657499423 0.403710658864798 no 2037 0.419534431699344 2770 7066794
SGTC_1216 1165-0504 9.65 µM -0.203395005454188 0.403580305007477 no 2038 0.419413151647285 2857 6304004
SGTC_917 harmaline 728.087 nM -0.203538409853504 0.403520075211195 no 2039 0.419357113608635 2882 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_315 k915-0449 187 µM -0.203541799367617 0.403518651644158 no 2040 0.419355789110315 2793 20970215 YNL149C PGA2
SGTC_314 1671-0008 2.74 µM -0.203805444581488 0.403407926819591 no 2041 0.419252768990791 2753 3913060
SGTC_1976 st070609 63.5 µM -0.204846785290076 0.402970663839522 no 2042 0.418845916313501 2706 682556
SGTC_2844 9010103 25.97 µM -0.205343197386721 0.402762261152205 no 2043 0.418651998214272 2959 2480525
SGTC_1711 st032263 62.8 µM -0.205737683825625 0.402596668377296 no 2044 0.418497910380574 2825 3958979
SGTC_504 lovastatin 124 µM -0.206876791991811 0.402118605422494 no 2045 0.418053040871252 2786 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_640 3381-0960 37.1 µM -0.207319344289789 0.401932913726572 no 2046 0.417880233882614 2816 1745025
SGTC_593 1203-0218 61.7 µM -0.207511789103176 0.40185217219853 no 2047 0.41780509333819 2907 3666956
SGTC_2985 9022375 71.43 µM -0.209211359971442 0.40113928792936 no 2048 0.417141622337305 2972 4939335
SGTC_3325 9138760 55.175 µM -0.209264923211861 0.40111682618679 no 2049 0.417120716379382 2816 43844959
SGTC_1555 citronellol 128 µM -0.210193883494913 0.400727318781429 no 2050 0.416758176599225 2837 8842 A terpine precursor.
SGTC_1228 0124-0032 52.5 µM -0.212195838537765 0.399888247143667 no 2051 0.415977126593117 2854 X1228
SGTC_1401 3807-4679 7.6 µM -0.212215252809754 0.39988011237113 no 2052 0.415969553857827 2762 3291456
SGTC_3331 9141060 1.957 µM -0.213310268110269 0.399421360538736 no 2053 0.415542482532206 2785 4906567 YPR165W RHO1
SGTC_1060 3448-7350 82 µM -0.214019993388929 0.399124098377299 no 2054 0.415265732962602 2898 570178
SGTC_2560 caryophyllene 100 µM -0.215312795282972 0.398582770143382 no 2055 0.414761727189399 2773 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1948 st076329 66.6 µM -0.215623281846698 0.398452790725307 no 2056 0.414640703191878 2730 24208413
SGTC_806 3966-4455 5.86 µM -0.215978185037531 0.398304230911212 no 2057 0.41450237604158 2786 714982
SGTC_1997 st073024 93.8 µM -0.216981952883425 0.39788414107712 no 2058 0.414111204706564 2896 686268
SGTC_1079 idarubicin 2.36 µM -0.217433878840534 0.39769504282871 no 2059 0.413935115596509 2811 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_258 haloperidol 50.781 µM -0.217828690872576 0.397529862286384 no 2060 0.413781294601552 2821 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2275 7947463 200 µM -0.218488249729098 0.397253958577879 no 2061 0.413524356269555 2764 1225414
SGTC_1437 4092-1038 11.6 µM -0.218570899760229 0.397219388408469 no 2062 0.413492161658502 2818 3977136
SGTC_3211 9128781 49.47 µM -0.219249709225665 0.39693549218869 no 2063 0.413227767486485 2924 17194361
SGTC_1850 st056238 17 µM -0.219414781052097 0.396866462998179 no 2064 0.413163478467442 2747 5393177
SGTC_741 4582-0002 126 µM -0.220033698848135 0.396607674789277 no 2065 0.412922454942299 2791 2912688
SGTC_2347 9049783 174.81 µM -0.220876833923082 0.396255207859044 no 2066 0.412594167900606 2962 6467988 YPL169C MEX67
SGTC_1612 st002233 45.4 µM -0.221037530386288 0.396188039397335 no 2067 0.412531605298357 2792 1035021
SGTC_2750 bromebric acid 70.15 µM -0.222097370114133 0.395745121206124 no 2068 0.412119042542211 2938 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_618 k072-0232 33.2 µM -0.224350379118705 0.394804012833914 no 2069 0.411242339127225 2889 5872756 YGL099W LSG1
SGTC_1956 st077085 54 µM -0.224871320636019 0.394586496558205 no 2070 0.411039690369332 2843 24208685
SGTC_1103 duloxetine 36.1 µM -0.225487359987993 0.394329315113417 no 2071 0.410800078733485 2968 60835 A selective serotonin reuptake inhibitor.
SGTC_3189 9110682 49.47 µM -0.225787692135932 0.394203950441329 no 2072 0.410683275081296 2908 17122418
SGTC_1317 1273-0028 910 nM -0.226736743702408 0.393807869344725 no 2073 0.410314226877024 2841 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1691 st019933 84.6 µM -0.227281871742307 0.393580412993662 no 2074 0.410102284263984 2788 6176082
SGTC_1914 st062367 72.6 µM -0.227503798515181 0.393487823760664 no 2075 0.410016007942183 2820 978205
SGTC_133 0724-0033 378.92 µM -0.228217767642823 0.393189992270356 no 2076 0.409738474649053 2764 280309
SGTC_378 3970-0959 8.33 µM -0.229119106308523 0.392814089045532 no 2077 0.409388171866945 2938 6615653
SGTC_1324 1418-0026 34.4 µM -0.229386843189531 0.392702448636525 no 2078 0.409284130590249 2910 1372513
SGTC_3175 9106517 49.47 µM -0.22964695452089 0.392593996367987 no 2079 0.409183058684909 2895 41468073
SGTC_390 dec-rvkr-cmk 16.7 µM -0.229818173310643 0.392522612002229 no 2080 0.409116531201203 2870 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_49 0717-0965 32.132 µM -0.230772396464361 0.392124844534317 no 2081 0.408745813437043 3101 5889349 YGL099W LSG1
SGTC_279 1273-0055 2.93 µM -0.230843506183542 0.392095206988896 no 2082 0.408718190421099 2879 2847562
SGTC_703 3875-0075 71.8 µM -0.232085151336337 0.39157780753846 no 2083 0.40823593878055 2841 2850814
SGTC_1253 0550-0034 176 µM -0.233109255999692 0.391151202493437 no 2084 0.407838283815794 2937 5969915
SGTC_2690 usnic acid 100 µM -0.235247566663845 0.390260882063236 no 2085 0.407008294432452 3051 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2219 9098279 200 µM -0.235529410047555 0.390143574792719 no 2086 0.406898927439666 2833 902349
SGTC_589 1227-0070 34.1 µM -0.235810324932184 0.390026663930191 no 2087 0.406789927967223 2952 2841384
SGTC_2731 amoxapine 43.43 µM -0.235893310483456 0.389992128993153 no 2088 0.406757729625944 2828 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1772 st048439 82.2 µM -0.23598597555631 0.389953566891047 no 2089 0.406721776381304 2901 2927068 YDL195W SEC31
SGTC_97 0535-0701 19.132 µM -0.23693130924805 0.389560232994067 no 2090 0.406355040079912 2838 2832013 YGL099W LSG1
SGTC_608 k048-0125 159 µM -0.237019937154875 0.38952336253843 no 2091 0.406320661643238 2932 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_29 0299-0004 12.984 µM -0.237427806701947 0.38935369589382 no 2092 0.406162459870134 2818 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2180 6301957 200 µM -0.238445804745749 0.388930318473793 no 2093 0.405767672332889 2922 845462
SGTC_3230 9131665 49.47 µM -0.239213211249669 0.3886112472541 no 2094 0.405470129458631 2820 15943720
SGTC_1000 4048-0884 8.67 µM -0.239344197127656 0.388556793627205 no 2095 0.405419348379216 2959 13040088
SGTC_208 k072-0098 12.366 µM -0.240732816618814 0.387979649718869 no 2096 0.404881101407822 2816 5948901
SGTC_909 3448-9333 149 µM -0.240853126379668 0.387929657692373 no 2097 0.40483447623447 2818 3344074
SGTC_1614 st002383 48.6 µM -0.241629496150026 0.387607099322351 no 2098 0.40453363229015 2839 1947235
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.242310713685122 0.387324137726641 no 2099 0.404269706392588 2834 368090
SGTC_1311 1190-0148 100 µM -0.242978773753361 0.387046699557955 no 2100 0.404010920433958 2965 1961333
SGTC_2732 terfenadine 20 µM -0.243251513342308 0.38693345031477 no 2101 0.403905281559732 2830 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_610 4215-0184 155 µM -0.243566281037769 0.386802761770124 no 2102 0.403783372859073 2890 5605015
SGTC_969 1313-0238 134 µM -0.244206329279728 0.386537059442008 no 2103 0.40353551269381 2846 5212874
SGTC_2088 5278280 127.392 µM -0.244715815956792 0.386325594964357 no 2104 0.403338240483755 2922 791502
SGTC_1023 4482-3888 16 µM -0.244892167223818 0.386252407529271 no 2105 0.403269963357471 3038 3303168
SGTC_3169 9102970 49.47 µM -0.245026437396093 0.386196686858 no 2106 0.403217980556292 2842 17027839
SGTC_1848 st056003 16.4 µM -0.245174664456349 0.386135176954787 no 2107 0.403160596321241 2841 146492
SGTC_514 4466-0038 2.65 nM -0.246580952836022 0.385551750909178 no 2108 0.402616273442016 2877 5722064
SGTC_1080 nisoldipine 24.4 µM -0.247083889648759 0.385343160579719 no 2109 0.402421650729612 2801 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2587 piperic acid 92.2 µM -0.247242072720633 0.385277561857069 no 2110 0.40236044322899 2931 5370536
SGTC_615 k087-0205 167 µM -0.247399284895162 0.385212369019016 no 2111 0.402299613780014 2858 9642773
SGTC_2979 9012552 45.46 µM -0.24828476182485 0.384845239559492 no 2112 0.401957044126375 2950 17100905
SGTC_40 0327-0103 19.753 µM -0.249242014655511 0.384448467060301 no 2113 0.401586790826102 2880 409036
SGTC_717 1532-0246 73.2 µM -0.249460610387058 0.384357878098463 no 2114 0.401502253135662 2926 9561992
SGTC_1744 st037937 38.9 µM -0.250051683545806 0.384112961204894 no 2115 0.401273690066866 3039 1016152
SGTC_3298 9116858 71.43 µM -0.250952100511455 0.383739953663008 no 2116 0.400925571271547 2995 2506942
SGTC_2931 9014674 55.67 µM -0.254431778119776 0.382299474477264 no 2117 0.399581001573702 2868 2996810
SGTC_3217 9129673 49.47 µM -0.256277038853704 0.381536252462694 no 2118 0.398868462847737 3031 17248312
SGTC_1989 st071868 50.2 µM -0.256297556350764 0.381527768761899 no 2119 0.398860542002559 2998 16414057
SGTC_1634 st006576 41 µM -0.257454067967005 0.381049659367352 no 2120 0.398414134441297 3038 3915356
SGTC_1596 piperlongumine 63 µM -0.258397429221343 0.38065980210384 no 2121 0.398050100216983 3017 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1200 1643-0193 18.4 µM -0.258414175985959 0.3806528823619 no 2122 0.398043638598861 2882 5403974
SGTC_3256 9138902 49.47 µM -0.258822171252269 0.380484311035271 no 2123 0.397886225216674 2860 17228773
SGTC_1459 k035-0031 35.7 µM -0.259102312295306 0.380368578351416 no 2124 0.397778150377345 2827 3877128 YMR208W ERG12
SGTC_572 0960-0087 17.7 µM -0.260422426896015 0.379823353041797 no 2125 0.397268972721264 2891 6796365
SGTC_3070 9117005 49.47 µM -0.26063878504314 0.379734016928735 no 2126 0.397185538505201 2878 8779016
SGTC_3317 9138495 8.753 µM -0.261054172005555 0.379562518125811 no 2127 0.397025365975846 2867 17020139
SGTC_546 peri-Naphthalide 147 µM -0.263287490438731 0.378640865650288 no 2128 0.396164500417872 2940 223824 A penicillin ester.
SGTC_1943 st076331 65.2 µM -0.263312165150081 0.378630686660471 no 2129 0.396154992005171 2970 24208415
SGTC_878 0828-0289 13.7 µM -0.264027340838292 0.378335693843728 no 2130 0.39587942555225 2888 745350 YLR208W SEC13
SGTC_770 0389-1121 67.2 µM -0.265241477158342 0.377835054161582 no 2131 0.395411722318076 3061 6753108
SGTC_2002 4023503 131 µM -0.267413889985408 0.376939788945703 no 2132 0.394575253036418 2979 4736863 YCR052W RSC6
SGTC_1131 3454-3128 32.3 µM -0.267748789435398 0.376801833445708 no 2133 0.394446345946295 3026 710982
SGTC_2078 5212016 200 µM -0.267869111158574 0.37675227302526 no 2134 0.394400035394716 2851 1899708
SGTC_186 3455-3465 67.277 µM -0.268684280371486 0.376416559015805 no 2135 0.394086324776401 2867 755278
SGTC_820 1582-0060 59.9 µM -0.269019462674385 0.376278546808349 no 2136 0.393957352770847 2932 3848840
SGTC_3063 1327-0034 4 µM -0.26909759321226 0.376246378623584 no 2137 0.393927291242953 2958 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2172 5754775 163.918 µM -0.269163335742962 0.376219311539481 no 2138 0.393901996617859 2873 2263357
SGTC_3296 9122258 64.045 µM -0.270017335205447 0.375867763837648 no 2139 0.393573458611305 2971 4730474
SGTC_942 3253-1115 227 µM -0.271149936321878 0.375401689076748 no 2140 0.393137857995526 3072 46497897
SGTC_330 1488-0319 80.1 µM -0.271986946220067 0.375057369339364 no 2141 0.392816028262322 2940 6846614
SGTC_2990 9074105 71.4286 µM -0.272682997850726 0.374771111229506 no 2142 0.392548452668759 2944 6502001
SGTC_2434 5670830 169.91 µM -0.274500572295581 0.374023941414714 no 2143 0.391849981937446 2985 1549830
SGTC_825 1988-2224 89.6 µM -0.275330606458542 0.373682887536926 no 2144 0.391531126122527 2884 1180859
SGTC_3091 9116372 49.47 µM -0.275821040207739 0.373481419000875 no 2145 0.391342761297258 3048 17169793
SGTC_3028 9087778 49.47 µM -0.276287443917521 0.373289853998865 no 2146 0.391163649518152 2880 17217395
SGTC_674 0498-0004 451 µM -0.276899141619909 0.373038660177181 no 2147 0.390928775861634 2958 4231473
SGTC_1678 st019265 80.2 µM -0.280328949847253 0.371631210863147 no 2148 0.389612571026389 3133 5367020
SGTC_907 3448-6986 75.5 µM -0.28073112758409 0.371466285935794 no 2149 0.389458316033416 3082 590582
SGTC_2488 5268135 45.7 µM -0.281048117277948 0.371336311521148 no 2150 0.389336747126782 3043 1270356 YLR208W SEC13
SGTC_2481 5478948 45.16 µM -0.282218662271897 0.370856483387888 no 2151 0.388887924639975 3044 77792
SGTC_3205 9113483 49.47 µM -0.282343394271662 0.370805365247526 no 2152 0.38884010733463 3089 17018033
SGTC_733 4069-0007 56.1 µM -0.282913870138535 0.370571599743712 no 2153 0.388621430970129 2925 5717425 YNL287W SEC21
SGTC_1554 st069299 38.7 µM -0.283484184372961 0.370337948229187 no 2154 0.388402851838556 2979 24207999
SGTC_2752 diclazuril 33.15 µM -0.284255562779304 0.370021999029192 no 2155 0.388107268907505 3052 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_467 ro 31-8220 72.8 µM -0.285777929646749 0.369398709665672 no 2156 0.387524106536138 2957 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_48 0382-0018 55 µM -0.285979702284611 0.36931612537429 no 2157 0.387446833921051 3178 762596
SGTC_1260 0700-1617 7.75 µM -0.286128697861332 0.369255146277664 no 2158 0.387389776132851 3034 2853078
SGTC_776 4476-4378 112 µM -0.287287854271344 0.368780853305993 no 2159 0.386945960877443 2997 2892008
SGTC_1699 st031318 29.054 µM -0.287337218324044 0.368760659406586 no 2160 0.3869270637542 3017 5340658
SGTC_211 3455-0679 143.504 µM -0.288206230353381 0.368405222421531 no 2161 0.386594439953684 2998 748649
SGTC_2093 5331342 194.4 µM -0.288331581145096 0.368353961635514 no 2162 0.386546467444293 3060 33839
SGTC_358 0075-0058 9.45 µM -0.288610200251709 0.368240031902221 no 2163 0.386439844430653 2877 1069125
SGTC_1492 4158-0558 28.5 µM -0.290131483465107 0.367618170767172 no 2164 0.385857825418918 3019 3967268
SGTC_2819 7996655 46.38 µM -0.290809264135601 0.367341223218902 no 2165 0.385598599832924 2984 6456960
SGTC_205 1486-1330 71.903 µM -0.291201669065408 0.367180914404244 no 2166 0.385448543067157 2921 4118834
SGTC_679 0422-0091 41.4 µM -0.291369876783188 0.367112203751827 no 2167 0.385384225204403 2916 627384 YHR062C RPP1
SGTC_2873 9040596 71.43 µM -0.291659240770594 0.366994012307355 no 2168 0.385273587995273 3025 6463863
SGTC_2399 5884133 200 µM -0.29166604072912 0.366991234998834 no 2169 0.385270988169502 2928 722445
SGTC_1412 3909-8563 178 µM -0.291764698860837 0.366950940820141 no 2170 0.385233268820573 3016 23767530
SGTC_2919 7978188 46.38 µM -0.296191091017199 0.365144617897797 no 2171 0.383542076052005 3096 2980291
SGTC_92 0063-0024 660.874 µM -0.296434886687113 0.365045216175376 no 2172 0.383448993083776 2884 3594437
SGTC_1072 oxiconazole 14.9 nM -0.297206927097759 0.36473049543355 no 2173 0.383154266818037 2928 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_835 0312-0010 67.2 µM -0.297791237226614 0.364492363144045 no 2174 0.382931251494096 2907 1626196
SGTC_874 0599-0792 117 µM -0.298040198315235 0.364390916339533 no 2175 0.38283624158517 3096 765305
SGTC_777 1315-0167 517 µM -0.299346313850436 0.363858855424636 no 2176 0.382337910172838 3024 4221767
SGTC_1022 4477-0945 21.3 µM -0.29998254902854 0.363599772809777 no 2177 0.382095233416352 2934 4648966
SGTC_2354 9060492 162 µM -0.300486501171341 0.36339460169421 no 2178 0.381903045738975 3074 6471895
SGTC_2460 5552655 174.22 µM -0.300659703561498 0.363324095853069 no 2179 0.38183699982498 3062 5401989
SGTC_1040 k898-0338 155 µM -0.301731373702911 0.362887951999494 no 2180 0.381428424767195 3142 20969351
SGTC_2916 7875993 68.79 µM -0.301993886377156 0.362781142772192 no 2181 0.381328361735518 2986 1299250
SGTC_1928 4'-methoxychalcone 40.3 µM -0.303220364866138 0.362282263789886 no 2182 0.380860965111761 3152 641818
SGTC_1707 st032323 6.317 µM -0.304136743878722 0.361909672564659 no 2183 0.380511857174177 2967 3132057 YMR211W DML1
SGTC_2915 7971052 15.16 µM -0.305976823264475 0.361161908773456 no 2184 0.379811146189237 2998 5741558
SGTC_1815 st051655 58.2 µM -0.305990565529117 0.361156326240413 no 2185 0.379805914550566 3036 5984156
SGTC_1824 st053723 68.6 µM -0.307045367589356 0.360727921333713 no 2186 0.379404420305154 3011 675225
SGTC_2526 patulin 37.61 µM -0.307092555023248 0.360708760368303 no 2187 0.379386462166497 3091 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3145 9085516 49.47 µM -0.308091938392764 0.360303032190061 no 2188 0.37900618765435 3042 25236195
SGTC_1388 3346-4487 254 µM -0.309362402766419 0.359787478035414 no 2189 0.378522933393949 3031 3345614
SGTC_2575 plumbagin 510 nM -0.309487062798803 0.359736904746829 no 2190 0.378475525918567 2907 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_84 0443-0269 128.823 µM -0.311128814491359 0.359071092487872 no 2191 0.377851348337499 3019 6150058
SGTC_2396 5342950 42.78 µM -0.311219929074422 0.359034153489544 no 2192 0.377816716805704 3044 1886677
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.311968793358373 0.358730604446943 no 2193 0.377532119934054 3076 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2409 alverine citrate 63.97 µM -0.313678465969285 0.358037930301092 no 2194 0.37688262877711 3181 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_124 0136-0217 7.121 µM -0.314724302218657 0.357614439656925 no 2195 0.376485495373355 3113 3976905
SGTC_2357 9067248 200 µM -0.31503229207091 0.357489758654579 no 2196 0.376368567868349 3045 9150235
SGTC_3057 9095946 49.47 µM -0.315281110964008 0.357389042451778 no 2197 0.376274112740317 2918 24540043
SGTC_512 prima-1 270 µM -0.315421777227057 0.357332108357046 no 2198 0.376220717139789 3117 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2121 5257820 149.641 µM -0.315561193678856 0.357275683251809 no 2199 0.376167798293532 3113 791256
SGTC_529 4076-0302 30.3 µM -0.316376707468135 0.356945688261751 no 2200 0.375858297212828 2975 5816522
SGTC_3297 9117502 71.43 µM -0.31688551306249 0.356739855931311 no 2201 0.375665237442022 3038 7453720
SGTC_2789 5281112 71.43 µM -0.317064922727461 0.356667287447566 no 2202 0.37559717016097 3002 765948
SGTC_575 k072-0246 11.9 µM -0.317951804933258 0.356308633323446 no 2203 0.375260747654557 2957 6796779
SGTC_2602 kawain 100 µM -0.318257344441958 0.356185102916314 no 2204 0.375144868798849 2990 5369129
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.319122587439375 0.355835364874525 no 2205 0.37481677807051 3071 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2521 angolensin 13.4 µM -0.320420065599585 0.355311141371985 no 2206 0.374324958296753 3126 821428 A flavenoid.
SGTC_1508 1080-0625 72.9 µM -0.320932004802971 0.355104376469605 no 2207 0.374130959729872 2927 767111
SGTC_1510 1123-0200 71.5 µM -0.322127084417857 0.354621867063578 no 2208 0.373678210283074 3166 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2902 5787006 60.46 µM -0.32290633306862 0.354307373556025 no 2209 0.373383089968972 2970 591003
SGTC_3265 9137266 49.47 µM -0.323160352235353 0.354204876543193 no 2210 0.373286902805021 3054 17224265
SGTC_948 3448-0295 75.3 µM -0.323448300348096 0.354088701934811 no 2211 0.373177877619015 2956 678569
SGTC_1303 1160-0052 261 µM -0.323599561202299 0.354027680162903 no 2212 0.37312061010847 3000 3562476
SGTC_2928 9011484 9.79 µM -0.324152382474692 0.353804692471914 no 2213 0.37291133527397 3101 2994751
SGTC_2036 5160441 105 µM -0.324628781954357 0.353612570732746 no 2214 0.372731020588214 3039 134534 YIL048W NEO1
SGTC_1094 duloxetine 25.4 µM -0.324861696179817 0.353518654964941 no 2215 0.372642873931195 2956 60834 A selective serotonin reuptake inhibitor.
SGTC_2201 6605497 169.863 µM -0.326326832600507 0.352928086734215 no 2216 0.372088544466625 3009 670741
SGTC_325 2810-4341 181 µM -0.326755255002716 0.352755464782063 no 2217 0.371926502304198 3088 774970
SGTC_890 0929-0006 47.2 µM -0.328440695179538 0.352076653839255 no 2218 0.371289238831033 2985 1378169
SGTC_2065 5221596 34.26 µM -0.328985324281895 0.351857405101537 no 2219 0.371083390353695 3118 788581
SGTC_2834 9001755 58.44 µM -0.329950026309424 0.351469170534132 no 2220 0.370718861309127 3016 2989575
SGTC_85 0868-0259 160.055 µM -0.330609756745876 0.351203757855289 no 2221 0.370469637738097 3035 83173
SGTC_1376 2910-0861 41.3 µM -0.331660339456963 0.350781253264944 no 2222 0.370072875792346 2973 1112859
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.332571342541348 0.350415031622336 no 2223 0.369728939221576 3065 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_439 amiodarone 34.4 µM -0.33264402729425 0.350385818462712 no 2224 0.369701502586502 3002 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2115 tiliquinol 12.7705 µM -0.333028094165724 0.350231470568075 no 2225 0.369556538182657 3061 71208 A bioactive hydroxyquinoline.
SGTC_2010 4012422 159 µM -0.333111899796379 0.350197794243993 no 2226 0.369524908568079 3061 952393
SGTC_402 epigallocatechin gallate 10 µM -0.333895833703335 0.349882836536914 no 2227 0.369229081887598 2997 65064 An antioxidant.
SGTC_2960 9079389 5.97 µM -0.334498829295739 0.349640643876485 no 2228 0.369001587080451 3152 16457355
SGTC_2060 5238662 140 µM -0.334796280571945 0.349521195355894 no 2229 0.36888938321941 3082 790130
SGTC_218 alverine citrate 93.75 µM -0.335484775748577 0.349244771175077 no 2230 0.368629713587911 3129 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1386 3228-0095 33.8 µM -0.335758001541041 0.349135095803356 no 2231 0.368526681637556 3131 870181
SGTC_1360 1598-0022 39.8 µM -0.336701247734374 0.348756564894668 no 2232 0.368171061341755 3112 761525
SGTC_2653 dihydrofissinolide 100 µM -0.336897540329262 0.348677810290342 no 2233 0.368097069789602 3061 6857746
SGTC_404 fumagillin 50 µM -0.337423777087619 0.348466710880388 no 2234 0.367898731516277 3062 12015870 A methionine aminopeptidase binder.
SGTC_273 hydroxyurea 18.1 mM -0.339266388982022 0.347727918918251 no 2235 0.367204530202592 2981 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.341274925824616 0.346923257890354 no 2236 0.36644831117369 3016 229346 A bile salt which induces apoptosis.
SGTC_66 0109-0187 42.4 µM -0.34466311119715 0.345567446196981 no 2237 0.365173826829797 2961 759417
SGTC_769 0302-0231 76 µM -0.344981076127609 0.345440311072964 no 2238 0.365054298738176 3121 571869 YER009W NTF2
SGTC_2803 7707263 71.43 µM -0.345200546937257 0.345352568015707 no 2239 0.364971803805534 3013 2199229
SGTC_956 1185-0240 191 µM -0.34560298485919 0.345191697444903 no 2240 0.364820551230066 3023 1416193
SGTC_873 0591-4978 488 µM -0.345816242129695 0.345106461300313 no 2241 0.364740408980417 3217 3305145
SGTC_162 k030-0015 37.8 µM -0.347988660670955 0.344238622386716 no 2242 0.363924349700349 3094 1809920 YMR134W ERG29
SGTC_1212 0520-0165 585 µM -0.348249723429069 0.344134387971733 no 2243 0.363826324086598 3415 5403258
SGTC_1725 st036284 20.55 µM -0.348310477931865 0.344110132245757 no 2244 0.363803512852186 3234 707914
SGTC_1978 st071761 42 µM -0.354177946641027 0.341770629810932 no 2245 0.361602764908934 3033 5147680
SGTC_953 1188-0045 9.7 µM -0.354968639931502 0.341455822875783 no 2246 0.361306542522618 3134 6144426
SGTC_3332 9141069 11.198 µM -0.355137623754875 0.341388557884981 no 2247 0.361243245829068 3004 17332883
SGTC_1814 st052110 31.539 µM -0.355202966224295 0.341362549286777 no 2248 0.361218771355083 3163 674163
SGTC_362 0310-0100 9.03 µM -0.355722593487159 0.341155746210935 no 2249 0.361024161596495 3154 790235
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.356877974782472 0.340696094549701 no 2250 0.360591579482938 3064 6857784
SGTC_2859 9028643 45.46 µM -0.35917757100048 0.339781937792796 no 2251 0.359731127200569 3098 17151580
SGTC_987 1497-1013 404 µM -0.359557815186779 0.339630870175632 no 2252 0.359588917528276 3068 1676435
SGTC_2992 9074591 71.4286 µM -0.359903173645115 0.339493684668237 no 2253 0.359459771813928 3156 17741321
SGTC_1817 st052116 64.4 µM -0.359998914378022 0.33945565768274 no 2254 0.359423972707659 3174 4361398
SGTC_161 4065-0411 162.148 µM -0.360616557834434 0.339210376962002 no 2255 0.359193054866747 3159 1906281 YLR208W SEC13
SGTC_2056 5235370 200 µM -0.361643156251781 0.338802841374993 no 2256 0.358809355191736 3045 5511916
SGTC_690 glyoxal 20.3 µM -0.361752288682685 0.338759529433084 no 2257 0.358768574409275 3095 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1111 tnp00062 510.699 nM -0.363104921266353 0.338222880397868 no 2258 0.358263254259565 3199 676306
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.365550348658908 0.337253505802153 no 2259 0.357350315203369 3045 2346 DNA damaging agent; causes G2/M arrest.
SGTC_17 0960-0276 49.807 µM -0.366178673542761 0.337004610019108 no 2260 0.357115877382626 3053 6821114
SGTC_2651 TUB2.036 5 µM -0.366543271317951 0.336860216087686 no 2261 0.35697986498493 3212 15992207 YFL037W TUB2
SGTC_281 1672-3440 14.9 µM -0.366794304103458 0.336760811980938 no 2262 0.356886228321066 3150 6833000
SGTC_3236 9132701 49.47 µM -0.367116036490625 0.336633428878076 no 2263 0.356766232907857 3117 24282524
SGTC_2942 9052777 62.25 µM -0.367514464357386 0.336475705808085 no 2264 0.356617652291144 3070 6469503
SGTC_967 1306-0166 352 µM -0.36908665993781 0.335853611844103 no 2265 0.356031565957353 3201 4437607
SGTC_3279 9140807 49.47 µM -0.370894429777892 0.33513886028904 no 2266 0.355358082064732 3088 45595718
SGTC_521 r062-0005 13.8 µM -0.370970277898375 0.335108884669129 no 2267 0.355329834733396 3032 2832033
SGTC_2576 guaiol 23.12 µM -0.371483762624474 0.334905980136181 no 2268 0.355138623836473 3138 227829
SGTC_802 4112-3352 742 µM -0.372383541269543 0.334550546992187 no 2269 0.354803653191797 3201 704594
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.372561812385382 0.33448014340764 no 2270 0.354737299524425 3157 616764
SGTC_2130 NSC 7 2.4545 µM -0.373567140319087 0.334083224064068 no 2271 0.3543631924887 3164 21448
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.373773302410487 0.334001850921204 no 2272 0.354286491894229 3211 16725076
SGTC_2946 9065502 71.43 µM -0.374490763339471 0.333718726588045 no 2273 0.354019613647107 3088 16489101
SGTC_813 k007-0158 173 µM -0.376046910184302 0.333104965602991 no 2274 0.353441010921194 3107 6523916
SGTC_693 4161-2696 114 µM -0.377791923566165 0.332417245008523 no 2275 0.352792586963688 3183 805759
SGTC_1262 0737-0114 49.6 µM -0.378344544106773 0.332199571257885 no 2276 0.352587329472854 3235 765919
SGTC_592 k241-0073 46.5 µM -0.378548204380562 0.332119365027914 no 2277 0.352511695624139 3209 4230158
SGTC_2073 5212005 126 µM -0.378816387458387 0.332013759923705 no 2278 0.352412108667646 3066 691789
SGTC_1207 2099-0101 141 µM -0.379114527613876 0.331896373985753 no 2279 0.352301409341666 3169 5837381
SGTC_2478 5763493 32.33 µM -0.379953969318881 0.331565951474028 no 2280 0.351989792191117 3056 1365576 YLR208W SEC13
SGTC_181 1447-1644 8.07 µM -0.381778946262281 0.330848053210191 no 2281 0.351312668235904 3171 534600
SGTC_2708 st078559 56 µM -0.382401960785035 0.330603117763251 no 2282 0.351081618100082 3183 17250902
SGTC_3306 9127676 59.7925 µM -0.383175348057565 0.33029916483006 no 2283 0.350794877552623 3140 41905287
SGTC_3065 9113888 49.47 µM -0.38333937532429 0.330234714006933 no 2284 0.350734073828585 3261 16648368
SGTC_902 1120-0002 2.07 µM -0.384856816986361 0.329638708493413 no 2285 0.350171750619329 3075 3280475
SGTC_2652 actinonin 100 µM -0.385874495112617 0.329239237219873 no 2286 0.34979481023233 3064 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2828 7998861 71.43 µM -0.385908247999535 0.329225991466576 no 2287 0.349782310948571 3182 2988188
SGTC_2080 5212524 12.4 µM -0.386079159038991 0.329158923592178 no 2288 0.349719022104145 3200 260183
SGTC_232 clozapine 119 µM -0.387049303976574 0.328778329428426 no 2289 0.349359853847045 3117 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3172 9105863 49.47 µM -0.387216528662857 0.328712744021431 no 2290 0.349297957333548 3115 2348785
SGTC_2254 7938975 95.19 µM -0.387599208302612 0.328562677181273 no 2291 0.349156327446917 3249 2969277
SGTC_3148 9097893 49.47 µM -0.389855891054078 0.327678287729091 no 2292 0.348321556027961 3060 17174100
SGTC_322 k048-0136 19.3 µM -0.390852366321429 0.327288078157292 no 2293 0.347953182450768 3187 6823282
SGTC_308 4092-1169 104 µM -0.391035431624215 0.327216412149396 no 2294 0.347885523081952 3091 2268590 YDL196W YDL196W
SGTC_898 1000-0849 28.3 µM -0.391408840285753 0.327070250684233 no 2295 0.347747529454075 3170 6751807
SGTC_297 0986-0032 24 µM -0.391474360950078 0.327044606996037 no 2296 0.347723318291698 3070 2847425
SGTC_2767 sibutramine 71.45 µM -0.392942303668853 0.32647029314016 no 2297 0.3471810478259 3301 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1975 st070967 30.8 µM -0.393169183131686 0.32638156609082 no 2298 0.347097264506767 3257 261391
SGTC_1321 1326-2144 215 µM -0.393601143173181 0.326212664165471 no 2299 0.346937768544916 3198 3513030
SGTC_3268 9137683 49.47 µM -0.393845796160269 0.326117017511008 no 2300 0.346847445448073 3072 1953228
SGTC_1916 st067606 49.2 µM -0.394954478264475 0.325683723628075 no 2301 0.346438241785406 3153 19590279
SGTC_3064 1327-0027 10 µM -0.396180391307602 0.325204887728221 no 2302 0.345985977910776 3080 16000455 YPR107C YTH1
SGTC_2675 theaflavin digallate 100 µM -0.396766447874547 0.324976078645223 no 2303 0.345769847455701 3173 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1381 2324-0066 62.1 µM -0.397035001927546 0.324871251415495 no 2304 0.34567082480886 3207 10885928
SGTC_677 0929-0063 136 µM -0.397805153457065 0.324570707845417 no 2305 0.345386909105775 3156 1539583
SGTC_3025 9087895 49.47 µM -0.398567026324394 0.324273507298227 no 2306 0.34510613089664 3225 17173641
SGTC_2235 salicylic acid 500 µM -0.399540727933517 0.323893836981853 no 2307 0.344747410108947 3165 338 A COX inhibitor and kinase inhibitor.
SGTC_1523 st012844 44.7 µM -0.399601690680777 0.323870072188855 no 2308 0.344724955500526 3238 4274103
SGTC_63 0099-0242 26.702 µM -0.400019229769978 0.323707324384371 no 2309 0.344571176666824 3222 3898502 YLR359W ADE13
SGTC_749 1000-0129 128 µM -0.401762861453082 0.323028058630661 no 2310 0.343929278330487 3277 708470
SGTC_525 k781-2675 26.7 µM -0.402112084299843 0.322892082875965 no 2311 0.343800769856921 3216 3651118 YDL195W SEC31
SGTC_2693 st077581 40.7 µM -0.402971727586799 0.32255746727052 no 2312 0.343484511656919 3237 25238761
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.403803791624842 0.322233723690205 no 2313 0.343178504035878 3216 17037758
SGTC_1946 st076057 65.1 µM -0.403989708367072 0.322161404704495 no 2314 0.343110143607527 3116 953009
SGTC_2932 9016711 44.54 µM -0.404082569911406 0.322125285396836 no 2315 0.343076000918504 3245 7117328
SGTC_2277 7947813 106.88 µM -0.404493232727004 0.321965574657303 no 2316 0.342925026624321 3303 1246798
SGTC_2062 5245942 200 µM -0.40467560711986 0.321894658033625 no 2317 0.342857987334219 3161 1376160
SGTC_1597 7-benzyloxygramine 47.5 µM -0.405226774875917 0.321680374853275 no 2318 0.342655412789082 3115 260807
SGTC_2540 epiandrosterone 100 µM -0.407498569548963 0.320797772415521 no 2319 0.341820922271907 3136 441302 A steroid.
SGTC_2989 9073649 71.4286 µM -0.407653696066461 0.320737541919625 no 2320 0.341763968305205 3234 21367202
SGTC_1268 0828-0275 2.46 µM -0.407843859652347 0.320663714126724 no 2321 0.341694155558356 3219 745337
SGTC_1477 0139-0234 16 µM -0.40806780356419 0.320576780789672 no 2322 0.341611948340085 3172 620880
SGTC_2716 st080858 38.6235 µM -0.410771950903605 0.319527829250967 no 2323 0.340619881166447 3253 5296050
SGTC_2051 5263410 176 µM -0.410974266024832 0.319449408149868 no 2324 0.340545702277238 3251 227584
SGTC_2860 9025725 38.96 µM -0.411060778449342 0.319415876790697 no 2325 0.340513984357762 3067 40546248
SGTC_2442 5158906 48.48 µM -0.411667555752897 0.319180737428078 no 2326 0.340291554221419 3250 1893835
SGTC_792 4534-1957 155 µM -0.412371582029857 0.318908003122832 no 2327 0.340033544550665 3122 1717904
SGTC_1684 st024538 14.6195 µM -0.416414444978829 0.317343730902318 no 2328 0.338553380081189 3137 6732859
SGTC_517 1365-0151 113 µM -0.417073879454867 0.317088889481475 no 2329 0.338312184965 3295 768657
SGTC_1476 4112-3294 3.34 µM -0.418091615664767 0.316695750981601 no 2330 0.337940067417103 3260 704369
SGTC_3019 9081971 49.47 µM -0.41837273837666 0.316587193327136 no 2331 0.337837307675439 3310 16451803
SGTC_2808 7946468 45.46 µM -0.418599950513146 0.316499465190642 no 2332 0.337754262880702 3181 2970879
SGTC_86 0417-1630 471.922 µM -0.419970350704249 0.315970563487524 no 2333 0.337253556696686 3233 3634867
SGTC_2893 9048488 25.97 µM -0.422001332553063 0.315187404951563 no 2334 0.336512022402368 3170 6467338
SGTC_2777 climbazole 1.536 µM -0.427137906877301 0.313210421195082 no 2335 0.334639442198473 3222 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2810 7959871 45.46 µM -0.427807775482608 0.312952993341638 no 2336 0.334395537756284 3219 2974535
SGTC_487 nimodipine 119 µM -0.428038057553714 0.312864517904764 no 2337 0.3343117063757 3177 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2114 5491910 81.25 µM -0.42930864581514 0.3123765459225 no 2338 0.333849312875383 3261 2849228
SGTC_1945 st075991 56.6 µM -0.429471645375574 0.312313969395401 no 2339 0.333790012180656 3172 1084980
SGTC_2791 5663188 71.43 µM -0.430348318102262 0.311977502264673 no 2340 0.333471142053959 3300 54690634
SGTC_505 gw-5074 63.9 µM -0.430682935446642 0.311849117412575 no 2341 0.33334946417288 3269 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2356 9061756 188.97 µM -0.431378919916804 0.311582157674681 no 2342 0.333096437485431 3205 20104043
SGTC_77 0828-0286 12.516 µM -0.431576030544601 0.311506569660388 no 2343 0.333024791279992 3253 745345
SGTC_1456 k015-0012 13 µM -0.433591310733458 0.310734205956736 no 2344 0.332292622889294 3348 2989616
SGTC_2487 5918373 44.05 µM -0.435105574061193 0.310154406911292 no 2345 0.331742898824511 3332 2876279
SGTC_1282 0886-0010 32.4 µM -0.436693540915113 0.309546893975712 no 2346 0.331166807073291 3344 2836211 YNL267W PIK1
SGTC_3135 9127742 49.47 µM -0.436793642566639 0.309508615213405 no 2347 0.331130504988606 3199 3643468
SGTC_678 1218-2179 85.9 µM -0.437350487982046 0.309295715865582 no 2348 0.330928592751758 3240 6820081 YOR116C RPO31
SGTC_2912 7964298 10.93 µM -0.438010114746726 0.309043602829237 no 2349 0.330689475602515 3252 2975850
SGTC_293 4049-0273 38.5 µM -0.438120992997856 0.309001233366343 no 2350 0.330649288604361 3191 1380311
SGTC_1346 1488-2224 62.4 µM -0.438258660297058 0.308948630647626 no 2351 0.330599394831478 3287 3722427
SGTC_2735 sertaconazole 140 nM -0.439195816698585 0.308590647051132 no 2352 0.330259827983807 3244 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2969 9091408 28.7 µM -0.439508385142416 0.308471289715233 no 2353 0.330146603798432 3129 4286311
SGTC_1247 0448-0043 5.84 µM -0.4397651047374 0.308373273948582 no 2354 0.330053621824101 3277 3089013 YGL099W LSG1
SGTC_574 1315-0397 40 µM -0.441173520977455 0.307835782549753 no 2355 0.329543690575246 3207 6794277
SGTC_1969 st069479 40.1 µM -0.441450027888863 0.307730308061979 no 2356 0.329443615641804 3297 3895485
SGTC_2626 ethyl orsellinate 100 µM -0.442262331022127 0.307420544231718 no 2357 0.329149693005663 3139 75653 A natural product.
SGTC_1430 4049-0248 69.1 µM -0.442580065882955 0.307299416504923 no 2358 0.329034752980844 3277 22774488
SGTC_869 0564-0080 44.1 µM -0.442601431835033 0.307291272074015 no 2359 0.329027024465253 3213 6843321
SGTC_2050 5263056 171 µM -0.443734052356635 0.306859667580634 no 2360 0.328617436425875 3313 763468 YGL055W OLE1
SGTC_1225 1216-0074 20.6 µM -0.443926567320822 0.30678633303894 no 2361 0.328547837949195 3189 4241466
SGTC_72 0744-0168 198.391 µM -0.444294136688008 0.306646336667971 no 2362 0.328414969901256 3089 677577
SGTC_440 fluspirilene 35.1 µM -0.444538931518058 0.306553117155974 no 2363 0.328326494118956 3367 3396 An atypical antipsychotic.
SGTC_1786 berberine 21.6 µM -0.445424724605323 0.306215905818268 no 2364 0.328006423897286 3236 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1034 k072-0165 12.7 µM -0.446739390855624 0.305715729916251 no 2365 0.327531618553094 3319 5835461
SGTC_59 0330-0160 1.33 µM -0.448099655778671 0.305198586891137 no 2366 0.3270406382327 3285 4293482
SGTC_1035 k081-0041 55.2 µM -0.448384248344757 0.305090440139663 no 2367 0.326937953894476 3332 731709
SGTC_2656 pseudo-anisatin 100 µM -0.449054215434939 0.304835916134201 no 2368 0.326696273644991 3212 6708809 A neurotoxin.
SGTC_2273 7815444 169.05 µM -0.449491761504192 0.304669741048168 no 2369 0.32653847491617 3316 2824616
SGTC_1146 3579-1023 7 µM -0.449997923781503 0.304477556568029 no 2370 0.326355968821018 3307 X1146
SGTC_631 k072-0230 41.5 µM -0.450536735442105 0.304273034763844 no 2371 0.326161736065777 3270 5773147
SGTC_1990 st072050 59.8 µM -0.451193598305366 0.304023785950531 no 2372 0.325925011565685 3179 17233948
SGTC_1832 st054113 55 µM -0.451207973430273 0.304018332279079 no 2373 0.325919831748993 3307 1251267
SGTC_351 caspofungin 25 nM -0.451233291343517 0.304008727210797 no 2374 0.32591070897781 3209 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1857 st056007 79.3 µM -0.451726205696567 0.303821753136995 no 2375 0.32573311855385 3291 619834
SGTC_352 k048-0007 5.11 µM -0.451783882606888 0.303799878273545 no 2376 0.325712340920625 3289 6811911
SGTC_888 0916-0002 6.97 µM -0.45278091191596 0.303421850551108 no 2377 0.325353254919516 3339 2802138 YIL048W NEO1
SGTC_3313 9133968 57.047 µM -0.453291911865243 0.303228184333912 no 2378 0.325169278065951 3273 1494643
SGTC_1781 st038725 66.3 µM -0.453353073375011 0.303205008156267 no 2379 0.3251472607575 3166 4270275 YIL048W NEO1
SGTC_1776 st049249 45.9 µM -0.45405166155196 0.302940345531505 no 2380 0.324895821877073 3254 1822314
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.455603131140878 0.302352935896516 no 2381 0.324337695572177 3265 75037 A free radical scavenger.
SGTC_940 3232-1287 54.8 µM -0.456439732060897 0.302036398430756 no 2382 0.324036900012764 3307 1585493 YIL048W NEO1
SGTC_2737 bleomycin 30.5 nM -0.457064213251966 0.301800215925926 no 2383 0.323812445856546 3287 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2647 atorvastatin 60.16 µM -0.457475611601 0.301644667993062 no 2384 0.32366461399771 3252 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_561 1550-0330 72.9 µM -0.458018729585118 0.301439372675973 no 2385 0.323469492623007 3205 6812934
SGTC_3110 9122132 49.47 µM -0.458504362757818 0.301255859542943 no 2386 0.323295064424533 3384 918317
SGTC_126 0417-1624 672.48 µM -0.459284131637506 0.300961302467238 no 2387 0.323015070739511 3361 41912 YDL195W SEC31
SGTC_1162 k048-0130 20.1 µM -0.459824372102659 0.300757303240486 no 2388 0.322821143943389 3204 6797406
SGTC_2804 7954240 19.48 µM -0.460436887591153 0.300526087874316 no 2389 0.322601331294925 3307 828705
SGTC_1117 retinoic acid 1.10837 µM -0.46053572381344 0.300488786212626 no 2390 0.322565867872626 3359 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1624 st003710 6.25 µM -0.46095729031774 0.300329706784168 no 2391 0.322414623735381 3300 24207033
SGTC_2878 9043973 25.97 µM -0.461520416123848 0.300117268910973 no 2392 0.322212638646676 3349 6465167
SGTC_237 nikkomycin 200 µM -0.462775473418129 0.299644046234177 no 2393 0.321762656657869 3346 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1147 3809-1045 12.3 µM -0.464061968254127 0.29915932112567 no 2394 0.321301674391296 3231 325925
SGTC_1792 st045773 43.6 µM -0.46554688645931 0.298600277009531 no 2395 0.320769934317976 3189 2919270
SGTC_664 1222-0054 14.9 µM -0.468680090360776 0.297422245688257 no 2396 0.319649160076859 3254 6813991
SGTC_2120 5538279 151.968 µM -0.469394057834314 0.297154103315847 no 2397 0.319393997482264 3267 2058197
SGTC_1464 k208-0027 110 µM -0.469454773834295 0.29713130551083 no 2398 0.319372302324741 3405 X1464
SGTC_2528 xanthyletin 44.79 µM -0.470202909641202 0.296850459148201 no 2399 0.319105027776706 3204 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1129 3453-1384 223 µM -0.470978410948727 0.296559468219581 no 2400 0.318828076018986 3388 1084452
SGTC_1338 1486-1223 76 µM -0.471145435837455 0.29649681267073 no 2401 0.318768440304337 3272 3444526
SGTC_1082 camptothecin 424.86 nM -0.473126071822766 0.295754285521987 no 2402 0.318061618540835 3026 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2142 5622915 118.518 µM -0.473291602467951 0.29569226789821 no 2403 0.318002576218817 3265 5322196
SGTC_1819 st053448 58.6 µM -0.474463002509626 0.295253562675319 no 2404 0.317584887483499 3208 2857616
SGTC_750 4073-0104 132 µM -0.474964175876372 0.295065957996584 no 2405 0.317406253836198 3275 22330957
SGTC_580 1123-0028 41 µM -0.475737232788672 0.294776686617072 no 2406 0.317130795889722 3309 1677248 YPR107C YTH1
SGTC_2533 agelasine 13.65 µM -0.476002161783815 0.29467758251207 no 2407 0.31703641889652 3434 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1808 st050063 61.5 µM -0.476967423226479 0.294316629518508 no 2408 0.316692659649951 3365 4011993
SGTC_500 h-89 112 µM -0.478122974914691 0.293884787505437 no 2409 0.316281340317953 3377 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_305 1682-2595 20.8 µM -0.479281275680473 0.293452212477588 no 2410 0.315869270451235 3311 226033
SGTC_1777 st045864 34.765 µM -0.482218742197438 0.29235652089519 no 2411 0.314825282043456 3328 4691462
SGTC_532 1548-0774 215 µM -0.482643669540655 0.292198178232804 no 2412 0.314674383196596 3458 5932993
SGTC_1168 k815-0004 80.5 µM -0.482824237984286 0.292130904251943 no 2413 0.314610269672521 3196 642433
SGTC_2387 9077560 195.08 µM -0.48288133390701 0.292109633651859 no 2414 0.31458999807502 3232 5303272
SGTC_1539 benzyladenosine 56 µM -0.482961156918232 0.292079897476721 no 2415 0.314561658284968 3249 92208 A nucleotide analog.
SGTC_254 nsc-64875 3.808 µM -0.485592441902473 0.291100464192616 no 2416 0.313628078124891 3382 56993
SGTC_2096 5468907 200 µM -0.486273790645786 0.290847098570209 no 2417 0.313386529636008 3322 759785
SGTC_1765 st044815 90.4 µM -0.486488047549955 0.290767446534741 no 2418 0.313310588839159 3311 645695
SGTC_700 3453-2283 142 µM -0.486644475435299 0.290709299427898 no 2419 0.31325514984511 3397 565664
SGTC_3124 9127567 49.47 µM -0.487045436458944 0.290560279720059 no 2420 0.313113066093926 3378 17592030
SGTC_1924 st058459 75.1 µM -0.487437439143603 0.290414623999897 no 2421 0.312974183623224 3335 688683
SGTC_3212 9128307 49.47 µM -0.488098553555066 0.290169052396292 no 2422 0.31274001778912 3128 27243542
SGTC_1600 coumarin 106 71.1 µM -0.488238407664038 0.290117115919748 no 2423 0.312690491331016 3394 100336 A hepatotoxic, DNA x-linker.
SGTC_1243 0416-0003 5.65 µM -0.48897031480348 0.289845384634323 no 2424 0.312431356635577 3244 2141977
SGTC_1178 0988-0033 191 µM -0.489342936766851 0.28970708912991 no 2425 0.312299463929041 3360 5392207
SGTC_2186 6124449 200 µM -0.489372432216276 0.289696143464964 no 2426 0.312289024791273 3346 3834182 YLR033W RSC58
SGTC_2614 arthonioic acid 13.39 µM -0.489551484923389 0.289629701755766 no 2427 0.312225657033667 3314 6710684
SGTC_1126 isoteolin 1.0172 µM -0.490144150176313 0.289409830444922 no 2428 0.312015949103167 3254 133323
SGTC_2465 5809242 33.21 µM -0.490199599515125 0.289389263453705 no 2429 0.311996332093639 3309 2731748
SGTC_1149 3909-7961 23.3 µM -0.491638670098359 0.28885573092246 no 2430 0.311487400629858 3303 735261
SGTC_2570 licareol 100 µM -0.492142121581192 0.288669186673752 no 2431 0.311309438508599 3294 443158
SGTC_935 2996-0153 430 µM -0.497113473285267 0.286830201519469 no 2432 0.309554516992485 3385 23738523
SGTC_550 4123-0385 25.7 µM -0.498380792335221 0.28636228891697 no 2433 0.309107836178784 3283 5731123
SGTC_837 0091-0265 12.5 µM -0.499485087991574 0.28595486256839 no 2434 0.308718844720634 3254 759367
SGTC_61 0978-8327 98.565 µM -0.499697330468739 0.285876587964925 no 2435 0.308644106235266 3380 6150059 YHR072W ERG7
SGTC_2435 5706476 10.6 µM -0.499956420124755 0.285781050025643 no 2436 0.308552881856163 3394 5725375
SGTC_2493 resveratrol 26.09 µM -0.500268203525703 0.285666101682909 no 2437 0.30844311989621 3346 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3006 9075424 71.4286 µM -0.503018380739438 0.284653120050947 no 2438 0.307475674616731 3284 7465181
SGTC_3054 9094397 49.47 µM -0.503529675281787 0.284464982503082 no 2439 0.30729596093759 3315 2598354
SGTC_1561 5-methoxyflavone 52.9 µM -0.504036034351635 0.284278719592393 no 2440 0.307118027609604 3344 94525
SGTC_3093 9117344 49.47 µM -0.506282063485631 0.283453227000867 no 2441 0.306329326375918 3400 24824913
SGTC_633 0437-0093 97.7 µM -0.506523168634851 0.283364680940775 no 2442 0.30624471465498 3327 2831118
SGTC_1098 clofazimine 15.1 µM -0.506687836767321 0.283304214059564 no 2443 0.306186933133419 3413 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2149 5554786 194.827 µM -0.506710678757947 0.283295826866274 no 2444 0.306178918332605 3298 745063 YPR165W RHO1
SGTC_3197 9113331 49.47 µM -0.507214941249019 0.283110700531846 no 2445 0.3060020062746 3460 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2234 tolnaftate 200 µM -0.509093415110869 0.282421581060693 no 2446 0.305343373604639 3323 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1371 2421-0008 32.7 µM -0.509724023249737 0.28219042302755 no 2447 0.305122410114139 3273 2827552
SGTC_1958 st076513 41.9 µM -0.511699318029803 0.281466941704836 no 2448 0.304430731744864 3273 732122 YGL099W LSG1
SGTC_2504 purpurogallin 52.29 µM -0.511702669507243 0.28146571493688 no 2449 0.30442955876924 3253 5281571 An antioxidant.
SGTC_2683 piperine 63.03 µM -0.513498751912188 0.28080865202084 no 2450 0.303801241808506 3315 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2606 farnesol 9.78 µM -0.514167036535989 0.28056436213712 no 2451 0.303567606007293 3441 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1286 0929-0070 131 µM -0.516503678072924 0.279711017619974 no 2452 0.302751335363529 3415 1420408
SGTC_2945 9067681 61.76 µM -0.516745059190884 0.279622936747612 no 2453 0.302667068544424 3430 16456930
SGTC_2390 9097792 176.6 µM -0.517032177020598 0.279518183912782 no 2454 0.302566848598444 3323 4497149
SGTC_2815 7968870 71.43 µM -0.521092902726917 0.278038701911898 no 2455 0.301151027410305 3352 2977326 YHR190W ERG9
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.522191914573311 0.277638946638107 no 2456 0.300768357500795 3495 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1623 st003709 20.3 µM -0.52273666347859 0.277440903455084 no 2457 0.300578760275462 3328 16192618
SGTC_1866 st057638 64 µM -0.522879108089155 0.277389129182231 no 2458 0.300529192018423 3332 688802
SGTC_1108 betulinic acid 729.144 nM -0.523411612958465 0.277195621745668 no 2459 0.300343922250877 3345 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_31 0508-1974 57.237 µM -0.524759526659477 0.276706097493078 no 2460 0.299875185252996 3395 6810525
SGTC_146 3448-8650 53.125 µM -0.525312936955012 0.276505237205852 no 2461 0.299682832756791 3325 2891488 YIL048W NEO1
SGTC_492 tmb-8 126 µM -0.52654898441345 0.276056872043979 no 2462 0.299253413484169 3331 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2768 sulfasalazine 50.2 µM -0.527139277046854 0.2758428746899 no 2463 0.299048436543141 3473 5384001 An antioxidant and salicylic acid derivative.
SGTC_2760 etidronate 98.04 µM -0.527163926624805 0.275833940311467 no 2464 0.299039878454806 3315 3305 A chelator and antioxidant.
SGTC_3218 9131285 49.47 µM -0.527668400704493 0.275651122077153 no 2465 0.298864754503821 3483 17156417
SGTC_2327 6189656 200 µM -0.528051356013893 0.275512381267378 no 2466 0.2987318458959 3392 5349088
SGTC_1921 5740136 50 µM -0.528428189719031 0.275375891788345 no 2467 0.298601088087216 3439 1774243
SGTC_1891 st059073 26.2 µM -0.528628300098559 0.275303425171682 no 2468 0.298531662219987 3441 688754
SGTC_3060 1327-0027 12.5 µM -0.529248281374103 0.27507896895794 no 2469 0.298316613872602 3346 16000455 YPR107C YTH1
SGTC_2846 9008642 19.48 µM -0.530423272454645 0.274653826047515 no 2470 0.297909246959513 3405 2992898
SGTC_2256 7954252 200 µM -0.530618152309555 0.27458334469544 no 2471 0.297841707055583 3363 2972920
SGTC_2669 eugenol 100 µM -0.53153926889548 0.274250329254169 no 2472 0.297522568370602 3380 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3074 9116018 49.47 µM -0.531639039748664 0.274214270621817 no 2473 0.297488010198899 3338 17027303
SGTC_69 0096-0274 206.684 µM -0.532504595929405 0.273901544379246 no 2474 0.297188279764543 3563 6741392
SGTC_16 erodoxin 22.806 µM -0.535228989023419 0.272918371000982 no 2475 0.296245761465918 3451 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1042 0350-0096 82 µM -0.536129436105224 0.272593804737315 no 2476 0.295934548725578 3326 3122515
SGTC_9 0092-0002 10.449 µM -0.536210528771817 0.272564584282922 no 2477 0.295906528828315 3424 759368
SGTC_2135 5326629 150.42 µM -0.536402205361751 0.272495522850346 no 2478 0.295840303782274 3330 5020077
SGTC_836 0330-0104 1.35 µM -0.536509064216142 0.272457025178594 no 2479 0.295803386566727 3406 46494820
SGTC_1712 st032288 53.4 µM -0.539577341362962 0.271352781108156 no 2480 0.294744273150706 3448 2883011
SGTC_3216 9129716 49.47 µM -0.542861814666916 0.270173206755941 no 2481 0.293612474449039 3342 8056934
SGTC_1791 st048313 56.1 µM -0.545618983344469 0.269184990709509 no 2482 0.292663936281346 3409 1204976
SGTC_379 3970-0972 5.9 µM -0.546848378882868 0.268744939765254 no 2483 0.292241451383761 3400 2898042 YBL034C STU1
SGTC_1411 3909-8223 150 µM -0.550116700976507 0.267576833720733 no 2484 0.291119666190055 3456 X1411
SGTC_1663 st014140 55.4 µM -0.550364435403391 0.267488397324795 no 2485 0.291034718433682 3492 4207120
SGTC_2499 avocadenofuran 51.48 µM -0.551118926722914 0.267219149360409 no 2486 0.29077607587561 3306 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2025 5147754 141 µM -0.55134601138152 0.267138138659024 no 2487 0.290698251418449 3420 315777 YLR208W SEC13
SGTC_923 1900-2434 73.3 µM -0.552384719463138 0.26676774568053 no 2488 0.2903423987703 3424 5910570
SGTC_2784 7567673 72.73 µM -0.552644795786527 0.266675045693801 no 2489 0.290253330752252 3482 3471247
SGTC_735 3076-0345 636 µM -0.553855835370542 0.266243604846956 no 2490 0.289838756167029 3503 2888990
SGTC_1059 3448-6867 171 µM -0.555583625296634 0.265628680513366 no 2491 0.289247764000627 3458 3934407
SGTC_1828 st055811 49 µM -0.557701134063578 0.264876037878807 no 2492 0.28852424157966 3442 5877589
SGTC_1352 1496-0991 99 µM -0.558497250503795 0.26459334864579 no 2493 0.288252440750802 3400 3000039
SGTC_1643 st009866 20.2 µM -0.558603651369203 0.264555578894403 no 2494 0.288216123753615 3443 3156273 YOR207C RET1
SGTC_2345 9052315 157.45 µM -0.558731603937096 0.264510162439302 no 2495 0.288172453536503 3446 6469265
SGTC_2097 5376186 200 µM -0.558945997347784 0.264434072909508 no 2496 0.288099288054096 3445 742755
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.560088407463684 0.264028812507622 no 2497 0.287709568602242 3393 5106787 A p450 inhibitor.
SGTC_337 1315-0038 354 µM -0.560566581788622 0.263859278186986 no 2498 0.287546519177818 3404 1626437
SGTC_2388 9080168 200 µM -0.560686560564104 0.263816749022249 no 2499 0.287505615284634 3379 15943073
SGTC_1694 st024011 44.9 µM -0.562601162668404 0.263138548673698 no 2500 0.286853250070041 3499 2787533
SGTC_1881 5652484 16 µM -0.564305375720072 0.262535623656869 no 2501 0.286273161777303 3461 2255129
SGTC_1809 st050081 57.6 µM -0.564867176939966 0.262337021894553 no 2502 0.286082055306366 3544 5036894
SGTC_2444 5485484 36.41 µM -0.565945333876321 0.261956099400683 no 2503 0.285715471325146 3500 6790631
SGTC_2267 7931562 200 µM -0.566490701700199 0.261763524131845 no 2504 0.285530126036654 3318 934880
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.567470422052232 0.261417756813555 no 2505 0.285197308255402 3375 390807
SGTC_2367 9070478 135.38 µM -0.567971501034523 0.261241004463277 no 2506 0.285027159743934 3450 572802
SGTC_1468 k284-1086 134 µM -0.568091558013367 0.261198664265653 no 2507 0.284986399874261 3473 15996457
SGTC_2330 7979373 200 µM -0.56840807619517 0.261087055487486 no 2508 0.284878953892821 3403 1863007
SGTC_1511 0906-3109 28.5 µM -0.570383431511998 0.260391071643506 no 2509 0.284208832309827 3490 2882180
SGTC_3282 9108498 15.4605 µM -0.570602474326952 0.260313954425041 no 2510 0.284134570444035 3424 16459645
SGTC_3048 9093155 49.47 µM -0.570787234073399 0.260248916210658 no 2511 0.284071938748354 3472 25236002
SGTC_1984 st072354 53.1 µM -0.570787800007399 0.260248717006228 no 2512 0.284071746912565 3387 5762938
SGTC_1272 0839-0021 27 µM -0.571949297117307 0.259840044552425 no 2513 0.283678162530863 3446 5027250
SGTC_2839 9003951 25.97 µM -0.573034388154131 0.259458554913927 no 2514 0.283310705221747 3474 2990634
SGTC_2970 9090938 41.86 µM -0.57348687712455 0.25929955713546 no 2515 0.283157540956783 3513 17217104
SGTC_934 2950-0684 338 µM -0.573853828141423 0.259170653081103 no 2516 0.283033359855241 3508 1121253
SGTC_1903 st060211 78.3 µM -0.574034429793121 0.25910722276005 no 2517 0.282972251456183 3517 688960
SGTC_3254 9136651 49.47 µM -0.575377726968239 0.258635686319226 no 2518 0.282517932123246 3433 16454030
SGTC_2571 chrysanthemic acid 100 µM -0.575789377655812 0.258491273924191 no 2519 0.282378777126936 3412 2743 An insecticide.
SGTC_612 0302-0167 22.4 µM -0.576861058682479 0.25811551032753 no 2520 0.282016659243418 3472 235821
SGTC_2309 7664088 163.95 µM -0.57710679486944 0.258029387767099 no 2521 0.281933657236354 3511 704922
SGTC_2274 7947094 46.08 µM -0.577676719706316 0.257829704984901 no 2522 0.281741199741367 3505 2971028
SGTC_739 1486-1183 203 µM -0.577680367919327 0.257828427030283 no 2523 0.281739967983045 3499 4346692
SGTC_3182 9108849 49.47 µM -0.577741417278556 0.257807042168475 no 2524 0.28171935606955 3511 17133045
SGTC_3220 9131269 49.47 µM -0.578043800160107 0.257701134627639 no 2525 0.281617274156029 3520 17722206
SGTC_2386 9075165 157.42 µM -0.57821928442627 0.25763968281993 no 2526 0.281558040327104 3456 16452277
SGTC_531 3788-1495 174 µM -0.578746150618356 0.257455228359395 no 2527 0.281380235416177 3435 2896655
SGTC_680 0417-1641 114 µM -0.580001716952837 0.25701593462458 no 2528 0.280956729976792 3404 2835990
SGTC_206 4546-0025 72.014 µM -0.580514204550524 0.256836739140553 no 2529 0.280783955296401 3497 6620745 YIL048W NEO1
SGTC_2339 9000433 200 µM -0.58219048164271 0.256251069621316 no 2530 0.280219191992221 3407 2988954
SGTC_762 1165-0429 115 µM -0.582412423520074 0.256173578229077 no 2531 0.280144457665933 3484 5967793
SGTC_897 1000-0139 31.4 µM -0.583562756498375 0.255772133351057 no 2532 0.279757261717674 3502 6151020
SGTC_1904 st060225 78 µM -0.584975403314249 0.255279595469202 no 2533 0.279282127830893 3494 66595
SGTC_2689 tacrolimus 100 µM -0.586109638800278 0.254884488544237 no 2534 0.278900919688308 3459 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_709 3807-1509 243 µM -0.586137915147864 0.254874642668947 no 2535 0.278891419452628 3522 1886677 YPL242C IQG1
SGTC_2728 chlorpromazine 9.18 µM -0.586220182605574 0.254845998123724 no 2536 0.278863780277726 3465 2726 A thorazine and dopamine antagonist.
SGTC_1901 st060216 58.6 µM -0.586823712697908 0.254635907697654 no 2537 0.278661054673445 3508 688792
SGTC_3215 9129942 49.47 µM -0.588405382737996 0.254085754818695 no 2538 0.278130112812551 3468 17682944
SGTC_1768 st044301 37.178 µM -0.588595017230952 0.254019836066919 no 2539 0.278066488623993 3446 3931349
SGTC_957 1187-1561 14.1 µM -0.589148873484372 0.253827361753911 no 2540 0.277880705209476 3491 1538454
SGTC_2840 9008771 71.43 µM -0.589979614365423 0.253538809000179 no 2541 0.27760215832835 3429 2992978
SGTC_2706 st078239 82.5 µM -0.59017132049533 0.253472245532965 no 2542 0.277537898764701 3516 15434492
SGTC_655 k060-0012 42 µM -0.590193934401402 0.253464394224774 no 2543 0.277530319101774 3434 5994525
SGTC_1826 st055655 41.6 µM -0.591479522118178 0.253018262038736 no 2544 0.277099585992554 3478 676168
SGTC_1342 1486-1464 234 µM -0.592539555926788 0.252650713919908 no 2545 0.276744670443654 3529 3253938
SGTC_1435 4092-0789 56.7 µM -0.594393180380022 0.252008678619306 no 2546 0.276124584321983 3521 2248285
SGTC_3227 9130768 49.47 µM -0.59468182804687 0.25190877796708 no 2547 0.276028085496117 3507 17720899
SGTC_3171 9103192 49.47 µM -0.594893817910854 0.251835421814207 no 2548 0.275957224961044 3558 13018434
SGTC_3310 9130229 44.1445 µM -0.596347523321043 0.251332691179696 no 2549 0.275471544728588 3503 7761258
SGTC_1669 st015249 58.4 µM -0.59797344043803 0.250771034257651 no 2550 0.274928827519547 3562 722793
SGTC_2792 7535235 81.82 µM -0.598173772784319 0.25070187745414 no 2551 0.274861994773874 3438 1281891
SGTC_1349 flufenamic acid 69 µM -0.598374301171758 0.250632663091644 no 2552 0.274795104647125 3493 3371 A non-steroidal anti-inflammatory.
SGTC_1066 ketoconazole 628 nM -0.59863523039679 0.250542615937246 no 2553 0.274708078667563 3553 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2196 6573537 42.6665 µM -0.598653743505554 0.250536227680731 no 2554 0.274701904630563 3561 2903087
SGTC_3266 9136860 49.47 µM -0.599088266788359 0.250386312973041 no 2555 0.274557012759142 3459 4871271 YPR165W RHO1
SGTC_3001 9076041 71.4286 µM -0.599682364701172 0.250181420458558 no 2556 0.274358971731178 3522 16004211
SGTC_319 1348-1596 45.5 µM -0.599959815301791 0.25008576375318 no 2557 0.274266508441603 3563 5380505
SGTC_391 gliotoxin 8.33 µM -0.600172132393904 0.250012576249206 no 2558 0.274195761963641 3568 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1339 1486-1321 22.7 µM -0.600246967527031 0.249986782652643 no 2559 0.274170828191793 3457 3469382
SGTC_982 1491-0518 27.5 µM -0.600652301353472 0.249847099856703 no 2560 0.274035797436284 3445 3091256
SGTC_1344 1488-0097 29.1 µM -0.60126067074664 0.249637526407895 no 2561 0.273833190189539 3521 747966
SGTC_3221 9128209 49.47 µM -0.602261004134224 0.249293130779956 no 2562 0.273500207002788 3512 16460723
SGTC_527 4476-4215 268 µM -0.603840912730803 0.248749713474399 no 2563 0.272974707919709 3410 4418754
SGTC_257 daunorubicin 18.5 µM -0.604277775926013 0.248599563632737 no 2564 0.272829489680679 3523 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2319 6033012 152.6 µM -0.604352253962612 0.24857397035612 no 2565 0.272804736167659 3432 847246
SGTC_843 0310-0051 143 µM -0.605443623567509 0.248199098362466 no 2566 0.272442136499958 3499 2065037
SGTC_775 4577-0580 57.3 µM -0.606424569061997 0.247862413139026 no 2567 0.272116428825904 3597 2006902
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.609324390049977 0.246868548709597 no 2568 0.271154721816519 3496 23665772 A membrane-active detergent.
SGTC_601 0986-0029 62.9 µM -0.611605334989467 0.246088294857937 no 2569 0.270399453751038 3541 24747981
SGTC_2333 9017922 200 µM -0.61282854806295 0.24567040999532 no 2570 0.26999485615685 3548 3163164
SGTC_2369 9071472 200 µM -0.61321944672459 0.245536948130609 no 2571 0.26986562398078 3540 17296037
SGTC_714 4296-0578 26.1 µM -0.613374281385797 0.245484094759388 no 2572 0.269814443778137 3526 1589775
SGTC_3087 9117406 49.47 µM -0.614235917616026 0.245190083807335 no 2573 0.26952972092206 3530 42546093
SGTC_2125 5246583 200 µM -0.616080657298898 0.244561251546381 no 2574 0.268920643753911 3600 835267
SGTC_719 2810-4230 27.3 µM -0.617461543979853 0.244091105947076 no 2575 0.268465169489012 3522 721079
SGTC_1842 st055362 61.2 µM -0.618199659401283 0.243840002455345 no 2576 0.268221867278196 3527 676032
SGTC_1836 st055642 81 µM -0.618559690244067 0.243717572212095 no 2577 0.26810323193393 3468 8571
SGTC_1457 k015-0032 57.3 µM -0.618775625916871 0.243644158157993 no 2578 0.268032090694964 3553 4302660
SGTC_1751 st044839 27.194 µM -0.618942092702315 0.243587570744221 no 2579 0.2679772537511 3565 5291326
SGTC_3340 9146634 11.102 µM -0.619449171113953 0.243415242233852 no 2580 0.267810248460092 3545 4907387
SGTC_1526 st051518 75 µM -0.619952474158225 0.243244261925953 no 2581 0.267644538444308 3441 673993
SGTC_931 2812-0076 566 µM -0.620090602772537 0.243197348723855 no 2582 0.267599069327178 3545 3450959
SGTC_2699 st077704 54.6 µM -0.620773461980837 0.242965498261216 no 2583 0.26737434325521 3533 645852
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.62163178479721 0.242674242513235 no 2584 0.267092007955731 3514 2724278 An inhibitor of dopamine biosynthesis.
SGTC_620 0109-0052 432 µM -0.622662695833379 0.242324672195532 no 2585 0.266753100852942 3572 493037
SGTC_823 0417-1665 178 µM -0.62301618542902 0.24220487071115 no 2586 0.266636942887976 3549 3429856
SGTC_2458 5808907 16.39 µM -0.625051769745098 0.241515614146131 no 2587 0.265968540513858 3630 2731747
SGTC_1277 0873-0036 22 µM -0.626105907142591 0.241159098313678 no 2588 0.265622738956866 3577 5965735
SGTC_357 1325-0123 420 µM -0.627606786731672 0.240651985512952 no 2589 0.265130780843261 3555 1098503
SGTC_2713 st079149 53.4 µM -0.627620937403336 0.240647207089178 no 2590 0.265126144741028 3554 3103253
SGTC_1957 st077035 62.4 µM -0.629147484291663 0.240132023478522 no 2591 0.264626252989643 3619 705593
SGTC_1213 1315-0166 115 µM -0.629417299670065 0.240041027938319 no 2592 0.264537947591316 3515 768401
SGTC_1944 st076371 56.9 µM -0.632086072434263 0.239141994739336 no 2593 0.263665317757022 3490 24208455
SGTC_200 k038-0079 37.545 µM -0.633925433472145 0.238523439456286 no 2594 0.263064743213874 3515 3436683
SGTC_2035 5154463 94.595 µM -0.636150802187019 0.237776246677688 no 2595 0.262339068012613 3580 2769623
SGTC_1188 1403-0014 4.57 µM -0.636458453994422 0.237673050201844 no 2596 0.262238825906345 3599 9614867
SGTC_370 0180-0345 38.7 µM -0.639258005544593 0.236735119169162 no 2597 0.26132755134617 3509 3989527
SGTC_2907 7721985 69.9 µM -0.642146869935449 0.235769403788475 no 2598 0.260388913040064 3541 3267881
SGTC_3250 9135583 49.47 µM -0.643115019793129 0.235446248639135 no 2599 0.260074734612501 3596 7699353
SGTC_1838 st055369 84.5 µM -0.643275412718397 0.235392735291462 no 2600 0.260022703700126 3562 676036
SGTC_2805 7950783 58.44 µM -0.643523946802632 0.235309827870585 no 2601 0.259942090703307 3571 1178958 YDL195W SEC31
SGTC_832 4083-0019 164 µM -0.643599873030286 0.235284503180387 no 2602 0.259917466306766 3664 1990758
SGTC_2684 capsaicin 100 µM -0.644863274485059 0.234863324905249 no 2603 0.259507896565344 3602 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_289 k017-0060 526 µM -0.649024649424371 0.233479004530483 no 2604 0.258161221909005 3566 5512909
SGTC_2139 5578692 56.4705 µM -0.649517455074331 0.233315368362212 no 2605 0.258001983916955 3539 650991 YMR113W FOL3
SGTC_345 1362-0200 395 µM -0.649938157563293 0.23317572442582 no 2606 0.257866084605009 3547 1419823
SGTC_2883 9059145 45.46 µM -0.650837561747245 0.232877340533161 no 2607 0.25757567516492 3586 16476510
SGTC_1733 st037357 54.9 µM -0.651492057524964 0.232660340200829 no 2608 0.257364451248503 3568 1272339 YGL099W LSG1
SGTC_1478 0453-0656 35.7 µM -0.651830411726444 0.232548201785329 no 2609 0.257255290280684 3609 5258496
SGTC_996 3970-0799 1.8 µM -0.653332414484641 0.232050766274472 no 2610 0.256770999830152 3664 6615648 YGL040C HEM2
SGTC_2303 7774051 200 µM -0.654822644423245 0.231557815687199 no 2611 0.256290974720252 3607 2953184
SGTC_1258 0671-0043 57.1 µM -0.655954332137574 0.231183856956716 no 2612 0.255926754111869 3579 4298767
SGTC_3320 9137005 35.139 µM -0.656088976250604 0.231139387140429 no 2613 0.255883438446398 3567 4908713
SGTC_2450 5739737 12.93 µM -0.656911693311605 0.230867766563289 no 2614 0.255618849504844 3610 2262825
SGTC_2366 9070441 60.58 µM -0.658346066866295 0.230394633742198 no 2615 0.255157891459094 3602 6837235
SGTC_2484 5809818 12.04 µM -0.658652819596608 0.230293520756716 no 2616 0.255059368196325 3599 2870548
SGTC_3274 9138298 49.47 µM -0.65935593414684 0.230061851157373 no 2617 0.254833616006118 3593 17015756
SGTC_387 norethindrone acetate 66.7 µM -0.662182260089858 0.229131920339213 no 2618 0.253927210963313 3603 541197
SGTC_1883 5-benzylidenerhodanine 20 µM -0.664215795933974 0.228464143221781 no 2619 0.253276102494624 3604 1273210
SGTC_120 rhodamine 6G 52.259 µM -0.664460083109707 0.228383997274081 no 2620 0.25319794441017 3647 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1565 sinapyl alcohol 95.1 µM -0.664898980439692 0.228240043158742 no 2621 0.253057553950869 3596 5280507 A phenol propionate derived from cinnamic acid.
SGTC_435 c-PAF 6.7 µM -0.66661916363924 0.22767633155722 no 2622 0.25250771253457 3579 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_262 fenpropimorph 62.5 µM -0.667154284156491 0.227501130174004 no 2623 0.25233679443424 3579 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1070 indatraline 8.81 µM -0.668561807576888 0.227040662017251 no 2624 0.251887521202797 3605 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3045 9092950 49.47 µM -0.670137721443867 0.226525729439788 no 2625 0.251385000181721 3652 44120432
SGTC_3170 9103054 49.47 µM -0.670168354004656 0.226515726734765 no 2626 0.251375237448141 3587 16432970
SGTC_2280 7785178 200 µM -0.672488892665484 0.225758707271817 no 2627 0.250636254458659 3626 2954328
SGTC_1196 1588-0294 184 µM -0.672716288717054 0.225684601892481 no 2628 0.250563901412093 3616 6144269
SGTC_2417 cerulenin 830 nM -0.674321448655879 0.225161893011384 no 2629 0.250053485322077 3692 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1936 st074407 74.3 µM -0.674462429549133 0.225116016375878 no 2630 0.250008681941543 3663 809813
SGTC_417 st075190 100 µM -0.674490759476595 0.225106798164599 no 2631 0.249999679274407 3640 222757
SGTC_954 1189-0853 2.85 µM -0.674490759476595 0.225106798164599 no 2632 0.249999679274407 3620 2828194
SGTC_684 1140-0066 328 µM -0.67609270242854 0.22458589363652 no 2633 0.249490894816926 3648 6813534
SGTC_1217 1183-1422 255 µM -0.677283490607867 0.224199127988217 no 2634 0.249113051823808 3667 2849664
SGTC_2287 7945887 168.79 µM -0.678017044279103 0.223961059591085 no 2635 0.24888044320851 3660 1245853
SGTC_2031 5180455 200 µM -0.678236904440441 0.223889733894672 no 2636 0.248810748452176 3622 29949
SGTC_731 3966-0296 387 µM -0.679148125482553 0.223594258765009 no 2637 0.248522005980951 3676 660956
SGTC_1993 st073995 70.8 µM -0.685345852345147 0.221590459536314 no 2638 0.246562852026643 3659 3098394
SGTC_1081 sertraline 6 µM -0.68552636155358 0.221532252972988 no 2639 0.246505915793179 3648 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_173 1273-0061 2.693 µM -0.687320447202999 0.220954211743068 no 2640 0.245940408249977 3620 2847414 YPL266W DIM1
SGTC_225 nsc-122657 1.016 µM -0.689416958396211 0.22027982642871 no 2641 0.245280457282515 3610 275685
SGTC_2197 6588183 93.1375 µM -0.689677882357088 0.220195977606 no 2642 0.245198388913359 3628 884136
SGTC_2077 5212015 200 µM -0.689750081230819 0.22017277948014 no 2643 0.245175682822124 3577 780900
SGTC_1250 0485-0349 40.2 µM -0.691358397538299 0.219656376965094 no 2644 0.244670170724246 3659 6842794 YDL195W SEC31
SGTC_1073 triclabendazole 3.09 µM -0.691746108745599 0.21953199373003 no 2645 0.244548392694955 3728 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_420 mitomycin C 81.9 mM -0.693937067901027 0.218829863793574 no 2646 0.24386083803829 3654 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2733 amorolfine 100 µM -0.694605478838882 0.218615917696581 no 2647 0.243651288888413 3664 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2181 6316240 54.2555 µM -0.695732456193418 0.218255465696715 no 2648 0.243298197853482 3653 12779990
SGTC_2204 7233102 200 µM -0.696108125600364 0.218135387880235 no 2649 0.243180559107021 3597 2172480
SGTC_2517 totarol 10 µM -0.696760440224137 0.217926974519228 no 2650 0.242976363559745 3633 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1654 st012436 41.8 µM -0.69914426480536 0.217166324029863 no 2651 0.242230938917232 3634 4323132
SGTC_170 4197-0004 226 µM -0.701288463722904 0.216483447411525 no 2652 0.241561505849007 3677 218692
SGTC_2174 5790901 200 µM -0.702205996164698 0.216191615067333 no 2653 0.241275353373519 3699 786020
SGTC_1603 st002045 67.8 µM -0.702432363514322 0.216119651230171 no 2654 0.241204784125368 3680 5887985
SGTC_2881 9058953 51.95 µM -0.702988886458 0.215942787505537 no 2655 0.241031337702909 3660 17122249
SGTC_1472 k841-0093 193 µM -0.704129953620496 0.215580417220488 no 2656 0.240675923911031 3751 X1472
SGTC_1316 1272-0050 65.9 µM -0.704252821953065 0.215541418794049 no 2657 0.240637670527058 3676 7340392
SGTC_1717 st033143 58.0435 µM -0.704965220116329 0.215315384162578 no 2658 0.24041594029034 3685 674616
SGTC_3127 9126946 49.47 µM -0.705676825485714 0.215089738451018 no 2659 0.240194567949312 3651 27243249
SGTC_425 3825-7017 13.1 µM -0.705705020023915 0.215080800963819 no 2660 0.240185799237534 3750 3397440
SGTC_1963 st076565 50.3 µM -0.706927267280594 0.214693563768313 no 2661 0.239805838986319 3700 4914280
SGTC_2240 6690706 185.951 µM -0.707203990688544 0.214605947449493 no 2662 0.239719859473622 3622 805876
SGTC_2980 9014342 25.29 µM -0.708306583001391 0.214257050506374 no 2663 0.239377444969762 3693 2996599
SGTC_2370 9071495 200 µM -0.708383820393788 0.214232622395319 no 2664 0.239353468601211 3642 21791103
SGTC_1750 st081859 2.357 µM -0.711079884244975 0.21338094576705 no 2665 0.238517367265406 3696 5291695
SGTC_833 3852-0053 558 µM -0.711154077009171 0.213357536485578 no 2666 0.238494381286564 3727 3123681
SGTC_2678 equilin 100 µM -0.711521756482066 0.213241548451517 no 2667 0.238380486828949 3705 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1952 st077036 64.1 µM -0.711550487853791 0.213232486412504 no 2668 0.238371588092831 3694 2937007
SGTC_158 k038-0087 26.446 µM -0.712283043717601 0.213001509971419 no 2669 0.238144760932861 3645 X158
SGTC_1706 st031321 9.9705 µM -0.715217347371208 0.212077782390546 no 2670 0.237237375722585 3696 6103185
SGTC_121 0557-0495 61.343 µM -0.715830566590282 0.211885035483477 no 2671 0.237047987938366 3821 3104427
SGTC_2281 7943571 200 µM -0.716536677725716 0.211663217805807 no 2672 0.236830014196128 3783 1244024
SGTC_3336 9143619 71.43 µM -0.717269594182811 0.211433123327539 no 2673 0.236603882371466 3729 45595730
SGTC_1298 1079-1278 263 µM -0.718205220031126 0.211139602482521 no 2674 0.236315379909905 3737 2840950
SGTC_1763 st044482 94.5 µM -0.719139948268777 0.210846601823569 no 2675 0.236027347750152 3726 88505
SGTC_2516 gossypol 71.55 µM -0.720359391628735 0.210464712810747 no 2676 0.235651872929094 3724 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2485 5633444 17.78 µM -0.72104706513106 0.210249535541385 no 2677 0.23544027899127 3715 5724239
SGTC_456 gingerol 170 µM -0.722340224261535 0.209845248180384 no 2678 0.235042664064222 3748 442793 A herb.
SGTC_1491 4138-0063 26.5 µM -0.724098600894374 0.209296251115712 no 2679 0.234502601744026 3668 23883227
SGTC_1198 1612-1005 86.7 µM -0.725534354630818 0.208848610342836 no 2680 0.234062138409892 3769 6998509
SGTC_1892 st058411 7.36 µM -0.726362536507137 0.20859065568658 no 2681 0.233808275684904 3683 3934738
SGTC_2317 5986382 200 µM -0.726451318475946 0.208563013827474 no 2682 0.233781070392449 3766 877883
SGTC_2253 7938677 135.83 µM -0.727053851605911 0.208375474969839 no 2683 0.233596483659358 3746 2301972
SGTC_3046 9092212 49.47 µM -0.728387916996625 0.207960600270865 no 2684 0.233188078861979 3734 25236637
SGTC_2773 thioridazine 9.09 µM -0.728868591962276 0.207811237028046 no 2685 0.23304102437317 3736 5452 An antipsychotic.
SGTC_1105 epirubicin 18.1 µM -0.729461141520365 0.207627197490446 no 2686 0.232859814610441 3718 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2685 mycophenolic acid 18.85 µM -0.733498516898124 0.206375797726875 no 2687 0.231627216036455 3718 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_190 3970-0790 3.722 µM -0.733519931864823 0.206369172015463 no 2688 0.231620687820935 3683 2832352
SGTC_3002 9075603 71.4286 µM -0.733691949100529 0.206315955092628 no 2689 0.231568253187959 3709 20105405
SGTC_332 4112-0506 40.9 µM -0.734119242322717 0.206183798709359 no 2690 0.231438033460856 3709 2790355
SGTC_2920 7982904 15.77 µM -0.735022651889405 0.205904550842759 no 2691 0.231162849389047 3730 6456808
SGTC_2553 4-methylesculetin 85.09 µM -0.735657192164173 0.205708545858569 no 2692 0.230969673750649 3783 5319502
SGTC_2704 st078022 71.1 µM -0.737311858651469 0.205197952272869 no 2693 0.230466361156928 3749 54697681
SGTC_302 1094-0063 18.9 µM -0.73874085296859 0.204757602718801 no 2694 0.230032186808369 3695 5440289
SGTC_1405 3909-7894 12 µM -0.738793785947996 0.204741302040397 no 2695 0.230016112866161 3743 7104060
SGTC_1965 Pectolinarigenin 58.4 µM -0.739426770848299 0.204546434540485 no 2696 0.229823945627982 3739 5320438 An anti-inflammatory.
SGTC_1241 0364-0022 50.8 µM -0.741754928417528 0.203830649925504 no 2697 0.229117916529603 3762 4563895
SGTC_222 nsc-310342 10.666 µM -0.74210627976624 0.203722757878706 no 2698 0.229011472673849 3691 432556
SGTC_396 dithiazanine 1.25 µM -0.742773094929668 0.203518087686249 no 2699 0.228809533606519 3736 10578 An antihelmenthic.
SGTC_2998 9066762 71.4286 µM -0.744333761440822 0.203039541212759 no 2700 0.228337290536977 3767 4945196
SGTC_1087 pterostilbene 9.05 µM -0.744797098105182 0.202897597951345 no 2701 0.228197194726387 3770 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3252 9135871 49.47 µM -0.745247192964697 0.202759768090099 no 2702 0.228061149031129 3757 17682838
SGTC_1438 4092-1045 4 µM -0.746535674631828 0.202365513462351 no 2703 0.227671944799643 3738 1351342
SGTC_383 2324-0395 7.37 µM -0.747350571429389 0.202116405007029 no 2704 0.227425986768441 3782 3146421
SGTC_2569 tetrandrine 100 µM -0.747390747933041 0.20210412806894 no 2705 0.227413864279063 3774 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_110 0850-0284 111.64 µM -0.747674298758627 0.202017494693193 no 2706 0.22732831860656 3587 3906265
SGTC_1485 3909-9022 254 µM -0.748522613425933 0.20175844158648 no 2707 0.227072495186654 3782 714516
SGTC_2082 5219693 150 µM -0.749408707583289 0.201488064144259 no 2708 0.226805452134482 3752 2834649
SGTC_2459 5811157 9.22 µM -0.753002936229396 0.20039357131224 no 2709 0.225724074793841 3744 2870684 YBR192W RIM2
SGTC_1382 3002-2117 298 µM -0.753808538740904 0.20014874493968 no 2710 0.225482098004093 3799 1497314
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.754245376734704 0.200016063035186 no 2711 0.225350947501348 3741 61125 An anti-inflammatory.
SGTC_381 3461-2219 42.7 µM -0.756814325044169 0.199236860365144 no 2712 0.224580554676409 3737 2883159
SGTC_983 1491-0821 12.2 µM -0.757082455773846 0.199155637573294 no 2713 0.22450023210327 3749 46495113
SGTC_2880 9042983 58.44 µM -0.758337336679923 0.198775771288729 no 2714 0.224124530489876 3783 6464714
SGTC_1209 2323-2347 50.3 µM -0.758732467769214 0.19865625123917 no 2715 0.224006305270211 3719 5412760
SGTC_912 3474-0017 2.18 µM -0.758749036277253 0.198651240510326 no 2716 0.224001348662934 3785 3360550
SGTC_285 1486-1325 46 µM -0.759115217722964 0.19854051759327 no 2717 0.223891818339025 3765 22310230
SGTC_1384 3089-0840 101 µM -0.761143299333355 0.1979279573775 no 2718 0.223285740299838 3731 1069836
SGTC_2923 7992654 58.14 µM -0.763770885377465 0.19713602316209 no 2719 0.22250189491534 3814 2985126
SGTC_1938 st074717 56.4 µM -0.764355766996916 0.196960005588342 no 2720 0.222327630365754 3645 17250979
SGTC_3109 9122853 49.47 µM -0.766819314213278 0.196219656671891 no 2721 0.221594475637126 3847 1234709
SGTC_1911 st060208 74.3 µM -0.766986977423727 0.196169331673643 no 2722 0.221544629125508 3836 688783
SGTC_2270 7924575 90.91 µM -0.76785984700802 0.195907461721518 no 2723 0.221285227311841 3808 1262135
SGTC_116 0155-0182 31.788 µM -0.767878994203272 0.195901719742278 no 2724 0.221279539042828 3744 771486
SGTC_1139 k015-0024 46.9 µM -0.768313823057316 0.195771348071882 no 2725 0.221150382144453 3759 2766652
SGTC_3275 9138069 49.47 µM -0.768723575447728 0.19564854310501 no 2726 0.221028713171585 3887 17617007
SGTC_2138 5575593 77.673 µM -0.770582087354821 0.195092124589412 no 2727 0.220477340980388 3769 762213
SGTC_1285 0929-0069 65.5 µM -0.77290814262629 0.194397085497066 no 2728 0.219788372715957 3795 1206237
SGTC_573 3702-0553 84.7 µM -0.773054000935285 0.194353552456014 no 2729 0.219745211286408 3747 1222756
SGTC_1619 st003326 88.7 µM -0.773552384027654 0.194204849252012 no 2730 0.219597769770923 3732 2849032
SGTC_1373 2887-0003 58.5 µM -0.774075755346469 0.194048764894384 no 2731 0.219442996922845 3793 776948
SGTC_37 0566-0070 1.56 µM -0.775520023907784 0.193618439158591 no 2732 0.219016218981777 3802 1626686
SGTC_2867 9039098 71.43 µM -0.775596620656124 0.193595633105913 no 2733 0.218993598161417 3759 6463460
SGTC_1180 1193-0155 285 µM -0.776965481661451 0.193188342284003 no 2734 0.21858956797637 3814 2921347
SGTC_1337 1486-1011 40.3 µM -0.777310509361441 0.19308576535371 no 2735 0.218487798070891 3800 X1337
SGTC_829 1635-0120 117 µM -0.778498975983791 0.192732688177226 no 2736 0.21813745504385 3829 285054
SGTC_2868 9035608 32.47 µM -0.779409543967231 0.192462437981899 no 2737 0.217869251778434 3772 6462614
SGTC_2726 cimetidine 79.27 µM -0.779534660126586 0.192425322495172 no 2738 0.217832414303477 3785 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3329 9141233 27.5565 µM -0.780755172703085 0.192063489221072 no 2739 0.217473251925934 3785 4909101 YNL103W MET4
SGTC_3005 9076496 71.4286 µM -0.780842295792093 0.192037676631962 no 2740 0.217447627140352 3809 21368410
SGTC_974 1326-0144 138 µM -0.7814985531889 0.191843310725195 no 2741 0.217254663664073 3857 5411856
SGTC_667 1498-1044 59 µM -0.782174906848286 0.191643118915938 no 2742 0.217055894687778 3811 6739982
SGTC_1660 st012960 28.1 µM -0.783459156763609 0.191263350079822 no 2743 0.216678764561303 3807 24207266
SGTC_2098 5376439 882.5 nM -0.783467133934429 0.191260992572735 no 2744 0.21667642318708 3837 2844116
SGTC_543 3844-1095 191 µM -0.785691346174018 0.190604362310344 no 2745 0.216024167151222 3826 4230703
SGTC_503 tyrphostin 8 294 µM -0.786689381964638 0.190310173270786 no 2746 0.215731860640879 3761 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1898 st060199 18.6 µM -0.786902372694872 0.190247426545462 no 2747 0.215669509234098 3804 688866
SGTC_226 1,3-diallylurea 8.28947 mM -0.787284194785312 0.190134974192584 no 2748 0.215557759895587 3773 74537 YKL182W FAS1
SGTC_2898 9056270 58.44 µM -0.787964062238022 0.189934844132342 no 2749 0.215358863625642 3765 19154699
SGTC_282 k297-0036 65.7 µM -0.788319343805622 0.189830312752998 no 2750 0.215254967831643 3799 5061378
SGTC_1933 st074711 15.9 µM -0.788419178245483 0.189800945709392 no 2751 0.215225778256398 3803 17250958
SGTC_2987 9018338 71.43 µM -0.789382052946657 0.189517852378625 no 2752 0.214944371078579 3868 5055682
SGTC_189 3970-0742 2.116 µM -0.790033239431657 0.189326545377566 no 2753 0.214754178251401 3794 2891807
SGTC_3269 9137823 49.47 µM -0.791825679056054 0.188800572757013 no 2754 0.214231163535324 3745 17682936
SGTC_2565 isoliquiritigenin 100 µM -0.792226076039303 0.188683203619531 no 2755 0.214114433312795 3895 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_46 0329-0187a 2.197 µM -0.792676711450963 0.188551161803367 no 2756 0.213983101049824 3885 46494817
SGTC_2892 9047358 58.44 µM -0.792960053627173 0.188468168181332 no 2757 0.213900548402253 3813 6466771
SGTC_355 1311-2252 105 µM -0.793524036671325 0.188303039240288 no 2758 0.213736285340425 3829 5338538
SGTC_2095 5432005 200 µM -0.79394813083301 0.188178927264283 no 2759 0.213612814071499 3825 783734
SGTC_385 1494-0393 12.4 µM -0.794836947511204 0.187918977156817 no 2760 0.213354177803368 3834 3090647
SGTC_3309 9129340 25.759 µM -0.796076434162031 0.187556837831938 no 2761 0.212993805255552 3866 17158987
SGTC_1044 1222-0021 1.78 µM -0.796805078317765 0.187344152150544 no 2762 0.212782122650706 3828 4306703
SGTC_3077 9117319 49.47 µM -0.798828769368064 0.18675423466501 no 2763 0.212194853133204 3800 17154678
SGTC_2463 5473429 200 µM -0.800137564079324 0.186373326515235 no 2764 0.211815549624533 3833 5399405
SGTC_2906 7926292 26.41 µM -0.801001526994655 0.18612214494843 no 2765 0.211565380921398 3805 2966319
SGTC_972 1319-0219 195 µM -0.801144751185053 0.1860805253942 no 2766 0.211523925712238 3815 23903702
SGTC_657 3534-0529 86.7 µM -0.801177420232134 0.186071032895523 no 2767 0.211514470558317 3854 1049549
SGTC_1281 0884-0031 11.8 µM -0.802069490053401 0.185811944183534 no 2768 0.211256381225168 3845 1548255
SGTC_1475 4092-1048 11.7 µM -0.802825604910273 0.185592516909361 no 2769 0.211037770264057 3863 2881759
SGTC_1801 st050089 28.441 µM -0.80346583982103 0.18540684418953 no 2770 0.21085276669962 3866 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1269 0831-0796 3.05 µM -0.80418465640492 0.185198519682909 no 2771 0.210645169394373 3855 927758
SGTC_1829 berberine 14.4 µM -0.806270548851317 0.184594818230011 no 2772 0.210043434043876 3870 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1446 4239-0190 62 µM -0.806828525362642 0.184433535702189 no 2773 0.20988264113585 3858 1340085
SGTC_3353 9151644 39.2805 µM -0.81152211634916 0.183080330330303 no 2774 0.208532948677039 3920 4909158
SGTC_2168 5727979 200 µM -0.811809032167162 0.182997811247654 no 2775 0.20845060926966 3776 695210
SGTC_781 4335-2806 94.4 µM -0.813471420506921 0.182520153128064 no 2776 0.207973912795812 3972 845254
SGTC_1343 1487-0095 224 µM -0.814349820109585 0.18226807515737 no 2777 0.207722288313789 3821 4560101 YGL055W OLE1
SGTC_764 1951-2361 146 µM -0.815541521067635 0.181926435790945 no 2778 0.207381203841493 3827 5438930
SGTC_1124 fisetin 1.16336 µM -0.816040889534855 0.181783394919822 no 2779 0.207238374849777 3879 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2408 sulbentine 18.36 µM -0.816216426646637 0.181733130165205 no 2780 0.207188181680022 3853 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2208 7283366 200 µM -0.816578099812324 0.181629593084913 no 2781 0.207084787345775 3831 898663
SGTC_323 4013-0906 34.3 µM -0.817036435772942 0.181498437145564 no 2782 0.206953803125347 3880 2910086
SGTC_2155 5570423 76 µM -0.817528662282094 0.181357649233757 no 2783 0.206813188207374 3803 797402
SGTC_2895 9054447 58.44 µM -0.818819534778628 0.180988755426102 no 2784 0.206444691919222 3887 2697450
SGTC_195 4234-0266 16.654 µM -0.819570525176837 0.180774360711312 no 2785 0.206230491079808 3864 2303354
SGTC_1994 st072947 40.9 µM -0.820152347442173 0.180608370062049 no 2786 0.206064631738131 3929 5286565 YDL195W SEC31
SGTC_21 0849-0113 22.993 µM -0.820288778126482 0.180569460986924 no 2787 0.206025751066297 3808 1560156
SGTC_1061 3448-9325 110 µM -0.821654547583825 0.180180242888682 no 2788 0.205636767358814 3775 723482
SGTC_1878 temozolomide 1 mM -0.821960267912187 0.18009319064351 no 2789 0.205549755146324 3774 5394 DNA alkylating agent.
SGTC_65 0798-0905 34.986 µM -0.822353345850288 0.17998130258779 no 2790 0.205437911882041 3901 3602145
SGTC_224 benfluorex 43.875 µM -0.823124900104625 0.179761809729953 no 2791 0.205218485097981 3833 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1908 st060353 56.5 µM -0.823129859468723 0.179760399427114 no 2792 0.205217075126255 3899 4227716
SGTC_192 3455-0609 60.9 µM -0.824381664305655 0.179404643874621 no 2793 0.204861364936123 3932 3769639
SGTC_1668 st014914 51.6 µM -0.825135568720166 0.179190602403762 no 2794 0.204647314074005 3880 2839556
SGTC_2269 7935389 174.42 µM -0.825323631013052 0.179137234562384 no 2795 0.204593939591654 3818 97605
SGTC_321 4534-3890 65.3 µM -0.826502995825442 0.178802785396202 no 2796 0.204259409670593 3887 699746
SGTC_1027 k015-0025 8.67 µM -0.826516985636784 0.178798820467888 no 2797 0.204255443379646 3859 3598955
SGTC_1909 st060837 51.5 µM -0.828217942510995 0.178317155558475 no 2798 0.203773542134563 3889 678937
SGTC_1729 st035615 45.989 µM -0.832215659470892 0.177188333083867 no 2799 0.202643613212749 3939 17385451
SGTC_2362 9071156 126 µM -0.833072025257937 0.176947112080113 no 2800 0.202402054833599 3906 653133
SGTC_1369 1866-0067 208 µM -0.833123789941889 0.176932537664844 no 2801 0.202387458891601 3856 3531355
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.834166260644438 0.176639190144812 no 2802 0.202093650363829 3849 7104
SGTC_1374 2889-5571 141 µM -0.836965465767202 0.17585302652503 no 2803 0.201305990002416 3914 2853281
SGTC_812 4251-0442 148 µM -0.841386373035774 0.174615925486829 no 2804 0.200065758505219 3853 5723007
SGTC_1995 st072814 61.1 µM -0.841398529214957 0.174612531463705 no 2805 0.200062354582683 3883 5769371
SGTC_984 1492-0255 2.91 µM -0.843423319516149 0.174047791672824 no 2806 0.199495867230677 3867 1585198
SGTC_1353 1498-1206 8.11 µM -0.844522691525884 0.173741649760631 no 2807 0.199188694376886 3939 6756808
SGTC_3302 9125395 16.351 µM -0.844774227254299 0.173671652836924 no 2808 0.199118453460425 3848 17599668
SGTC_454 lyso-paf C-16 6.67 µM -0.846031834312023 0.173321957284682 no 2809 0.198767492729506 3826 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_52 0329-0193 875 nM -0.846548899840162 0.17317830999232 no 2810 0.198623303376922 4004 3739292
SGTC_33 0986-0033 35.816 µM -0.84656943985101 0.173172605285761 no 2811 0.198617576874278 3810 2848082
SGTC_2018 5133068 143 µM -0.84684520229111 0.173096027636402 no 2812 0.198540704651968 3885 785362
SGTC_1223 0764-0573 147 µM -0.847928211025692 0.172795491056818 no 2813 0.19823897613886 3892 1609797
SGTC_1630 st005209 31.3 µM -0.849403722708441 0.172386569872483 no 2814 0.197828341200508 3839 3367314
SGTC_850 0388-0143 75.9 µM -0.85015791949013 0.17217779146277 no 2815 0.197618646837593 3853 67273
SGTC_123 0083-0120 66.675 µM -0.850744886900297 0.17201541756333 no 2816 0.19745554138057 3888 16001701
SGTC_841 0251-0215 91.2 µM -0.852352144286829 0.171571299431252 no 2817 0.197009336366693 3938 3888614
SGTC_3203 9113543 49.47 µM -0.852522705849183 0.17152421281632 no 2818 0.196962021100983 4010 17018012
SGTC_541 4513-1321 94 µM -0.852805540516593 0.17144614937533 no 2819 0.196883575459069 3910 747515
SGTC_1735 st034310 56.75 µM -0.853631411193886 0.17121833591261 no 2820 0.196654624283996 4007 871153
SGTC_3241 9133421 49.47 µM -0.853884843432358 0.171148466368852 no 2821 0.196584399136063 3905 17018221
SGTC_471 1-acyl-paf 4 µM -0.854075635171312 0.171095878416715 no 2822 0.196531541467463 3839 16759367
SGTC_1383 3049-0032 20.7 µM -0.855018952732978 0.170836023558275 no 2823 0.196270327753231 3986 712864
SGTC_1611 st001856 99.4 µM -0.858289734910473 0.169936981241164 no 2824 0.195366248117563 3899 647478
SGTC_675 1309-0189 238 µM -0.85852499722386 0.169872431656339 no 2825 0.195301316740031 3941 4246530
SGTC_3012 9080433 71.4286 µM -0.859870196057922 0.169503647639051 no 2826 0.194930299583652 3878 17688859
SGTC_2372 9071633 200 µM -0.861426724060374 0.169077569691156 no 2827 0.194501531345692 3974 21321366
SGTC_3295 9122362 53.5725 µM -0.865332491217768 0.168011451426441 no 2828 0.193428161218071 3978 4730473
SGTC_1092 toremifene 6.32 µM -0.865815123072168 0.16788001321518 no 2829 0.193295777241491 3921 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3092 9117248 49.47 µM -0.867504697817832 0.16742040219808 no 2830 0.19283276944942 4004 17141857
SGTC_415 dibenzyl ketone 100 µM -0.868843318233371 0.167056836668831 no 2831 0.192466417963627 3947 7593
SGTC_401 neomycin 50 µM -0.869296095730364 0.166933978885188 no 2832 0.19234259891493 3908 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1622 st003707 19.4 µM -0.870098656238895 0.166716353334727 no 2833 0.192123245992742 3966 10140899
SGTC_3150 9097574 49.47 µM -0.870902794410977 0.166498483672936 no 2834 0.191903615443274 3944 17217476
SGTC_721 1187-1332 279 µM -0.874704533932646 0.165470946964845 no 2835 0.190867346263535 3872 25730
SGTC_1467 k284-1082 293 µM -0.875817385116544 0.165170942592751 no 2836 0.190564658673917 3883 3334705
SGTC_473 2-arachidonoylglycerol 10 µM -0.876264185648041 0.165050592435107 no 2837 0.190443215069629 3794 5282280 An endocannabinoid.
SGTC_2344 7990960 76.95 µM -0.876845389194251 0.164894124473775 no 2838 0.190285310896623 3919 140813
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.877835539215658 0.164627783823549 no 2839 0.190016487463742 3899 4330530
SGTC_248 streptozotocin 5.23457 mM -0.878016492704487 0.164579139252569 no 2840 0.189967384251643 3945 5300 DNA alkylating agent.
SGTC_1875 nocodazole 6 µM -0.879463791076446 0.164190406496755 no 2841 0.189574928720565 3918 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3323 9138564 53.9225 µM -0.879544346158725 0.164168787554836 no 2842 0.189553099729193 3964 43912313 YNL103W MET4
SGTC_1827 berberine 7.24 µM -0.879785746076607 0.16410401299304 no 2843 0.18948769391621 3881 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_858 0438-0351 2.77 µM -0.880380298739275 0.16394454806876 no 2844 0.189326662786965 3932 2799119
SGTC_1687 st020778 55.3625 µM -0.88123883960054 0.163714456371798 no 2845 0.18909428068998 3955 4259299
SGTC_999 SEC7.066 22.7 µM -0.882132974771866 0.16347504824237 no 2846 0.188852451076413 3936 740511 YDR170C SEC7
SGTC_3050 9093513 49.47 µM -0.883521121730071 0.163103817312362 no 2847 0.18847738783195 3929 25236664
SGTC_624 k048-0052 28 µM -0.883712424736143 0.163052700307383 no 2848 0.188425735736975 3932 6835531
SGTC_1232 0279-0259 161 µM -0.884509030690873 0.162839955667012 no 2849 0.188210744833569 3970 1560000
SGTC_3106 9121286 49.47 µM -0.885263884098761 0.162638528260899 no 2850 0.188007161991361 3974 15943471
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.886368742412751 0.162343996843431 no 2851 0.187709428557623 4016 688664
SGTC_523 1934-0222 13.7 µM -0.889369028286087 0.16154593796146 no 2852 0.186902392246194 3930 1361595
SGTC_3010 9080089 71.4286 µM -0.88950418404619 0.161510047608606 no 2853 0.18686608778541 3966 17027233
SGTC_2543 pimpinellin 60.67 µM -0.890341190272924 0.161287898011549 no 2854 0.186641355067432 3796 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3251 9135047 49.47 µM -0.890502359675096 0.161245144978845 no 2855 0.186598100968705 3957 17682963
SGTC_548 1436-0017 110 µM -0.892288819883443 0.160771750005794 no 2856 0.186119072612494 4040 9677137
SGTC_2778 tioconazole 65.09 nM -0.892827046478793 0.160629303146302 no 2857 0.185974899999257 3866 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_544 k015-0020 52.4 µM -0.896276196109279 0.159718409830091 no 2858 0.185052634574094 3975 3008304
SGTC_203 k066-0004 30.888 µM -0.896607093042076 0.159631200574174 no 2859 0.184964305916728 4029 6795412
SGTC_2658 polymyxin b sulfate 77.05 µM -0.897791666253584 0.159319256911087 no 2860 0.184648314224885 3980 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_768 0384-0033 77.3 µM -0.899166410239519 0.158957734750528 no 2861 0.184282014484421 3958 3965305 YMR134W ERG29
SGTC_2648 atorvastatin 78.68 µM -0.899166715417698 0.158957654556276 no 2862 0.184281933220104 3976 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_536 3852-0578 10.6 µM -0.900519290127308 0.158602487507929 no 2863 0.183921982193558 4035 2869208
SGTC_445 e6 berbamine 66 µM -0.902274825560908 0.158142285274162 no 2864 0.183455447543344 4016 6610268 A calcium/calmodulin antagonist.
SGTC_991 3996-0057 64.7 µM -0.902406470846343 0.158107810676605 no 2865 0.183420492483992 4029 715343
SGTC_1745 st081495 74 µM -0.906670738112041 0.156993774081812 no 2866 0.182290470994244 3893 13842402 YBL026W LSM2
SGTC_2231 micatex 6.853 µM -0.909245943606193 0.156323510391071 no 2867 0.181610158762327 4006 20737 An antifungal of unknown mechanism.
SGTC_2239 6685329 187.64 µM -0.910879668272764 0.155899270005079 no 2868 0.181179389733346 4043 805680
SGTC_2866 9034245 58.44 µM -0.914019979061659 0.155085937688576 no 2869 0.180353173842031 3957 6462273
SGTC_799 1310-0557 151 µM -0.915710562246992 0.154649243235998 no 2870 0.179909361844345 4061 5354492
SGTC_2766 oltipraz 83.91 µM -0.915823681300451 0.154620052492235 no 2871 0.179879690326499 3932 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1709 st033179 39.1045 µM -0.918032422607949 0.154050809243101 no 2872 0.179300945887718 3959 573381
SGTC_965 1291-5240 308 µM -0.918648036452555 0.153892398837072 no 2873 0.179139848839546 4012 2834598
SGTC_219 mitoxanthrone 164.414 µM -0.919356320156584 0.153710275936121 no 2874 0.178954614136333 3960 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2666 tannic acid 100 µM -0.919982980930152 0.153549259978189 no 2875 0.178790826498996 3999 16134267 A thiamine antagonist.
SGTC_1778 st046819 58.9 µM -0.920003397564357 0.153544015951083 no 2876 0.178785491878735 4052 671715
SGTC_2389 9091542 195.52 µM -0.921383361593112 0.153189846125399 no 2877 0.178425156207613 3984 3626624 YOL127W RPL25
SGTC_2061 5245884 80.95 µM -0.924725707700702 0.152334273283576 no 2878 0.177554301782306 3971 573863
SGTC_2695 st077686 51.995 µM -0.925176570140549 0.15221910490167 no 2879 0.177437034423906 4037 2876092
SGTC_12 0849-0099 9.267 µM -0.925190210513518 0.152215621503542 no 2880 0.177433487384413 3886 6071388
SGTC_877 0771-0151 33.1 µM -0.925719933775415 0.152080384833976 no 2881 0.177295772892527 4033 6166523
SGTC_3324 9138759 60.749 µM -0.925801574488501 0.152059549317542 no 2882 0.177274554400811 4042 45595710
SGTC_2305 7443522 69.23 µM -0.927303064616032 0.151676692270401 no 2883 0.176884601811681 3907 5415886
SGTC_819 1013-0258 27.7 µM -0.928271312324114 0.151430143970859 no 2884 0.17663342556289 4030 5753198
SGTC_2427 5545055 42.75 µM -0.930824808192109 0.150781217136592 no 2885 0.17597209734797 3977 5372858
SGTC_642 0335-0876 158 µM -0.931279076355026 0.15066596700712 no 2886 0.175854611216458 4040 6812350
SGTC_2956 9076196 2.52 µM -0.93220579443933 0.150431035893283 no 2887 0.17561509074662 4023 16423868
SGTC_1803 st050068 52.4 µM -0.932283464915017 0.150411356841148 no 2888 0.175595025352436 4070 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1133 3473-0247 50 µM -0.934314406975243 0.149897394100247 no 2889 0.175070867425508 4013 711311
SGTC_2703 st077852 53.4 µM -0.93663433664092 0.149311733088599 no 2890 0.174473341641326 4066 6281836
SGTC_177 1327-0068 8.361 µM -0.938218464375135 0.148912702540643 no 2891 0.17406607564103 4017 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1144 3486-0183 12.5 µM -0.938610566671722 0.148814044862187 no 2892 0.173965362797813 4004 6744069
SGTC_681 1642-0006 26.6 µM -0.939277195620583 0.14864641324245 no 2893 0.173794221887995 4040 4446530
SGTC_507 nimesulide 162 µM -0.943588931179115 0.147565226569411 no 2894 0.172689875366092 4080 4495 A COX2 inhibitor.
SGTC_526 4469-0568 170 µM -0.94485108586652 0.147249734974682 no 2895 0.172367453330741 3961 2901964
SGTC_2058 5236698 133 µM -0.949496705071083 0.146092400364626 no 2896 0.171184023511169 4027 766665
SGTC_93 0109-0045 59.227 µM -0.949610582366364 0.14606410775381 no 2897 0.171155079685167 4128 88733
SGTC_1625 st003711 30.1 µM -0.951671595394617 0.145552688907164 no 2898 0.170631779581219 4125 24207034 YER133W GLC7
SGTC_2034 5197015 53.07 µM -0.951996257488013 0.145472237314746 no 2899 0.170549439954457 4031 780676
SGTC_2797 7859098 81.82 µM -0.952214755396251 0.145418110153796 no 2900 0.170494039629459 4026 972681
SGTC_468 gf-109203x 121 µM -0.952779640797395 0.145278237309586 no 2901 0.170350865884836 4000 2396 A protein kinase C inhibitor.
SGTC_3176 9106582 49.47 µM -0.957520998880834 0.14410778538229 no 2902 0.169152176323255 3979 17018027
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.958219962603385 0.143935778442073 no 2903 0.168975926510731 4060 5024745
SGTC_3349 9149703 23.001 µM -0.959036640519279 0.143734978888172 no 2904 0.168770143525529 4054 4910494
SGTC_2007 4011539 71.82 µM -0.960184606976505 0.143453043951849 no 2905 0.168481156282361 4020 45595301
SGTC_3114 9122766 49.47 µM -0.960851802988384 0.143289355548149 no 2906 0.168313343707981 4042 17176985
SGTC_3152 9099253 49.47 µM -0.962824377929054 0.142806146322831 no 2907 0.167817832366108 3977 25236131
SGTC_522 1273-0010 11.6 µM -0.967191113548702 0.141740376586145 no 2908 0.166724251872212 4160 5705015
SGTC_1970 st070122 35.8 µM -0.967651298918505 0.141628375789303 no 2909 0.166609274084746 4081 102928
SGTC_3193 9111931 49.47 µM -0.968784244248423 0.141352892939901 no 2910 0.166326424672389 4073 17087244
SGTC_2402 5553605 200 µM -0.97143248479671 0.140710373910438 no 2911 0.165666479285435 4153 6758546
SGTC_3078 9116413 49.47 µM -0.975280015439458 0.139780418232989 no 2912 0.16471069038851 3973 17177322
SGTC_2316 5844804 197.44 µM -0.976072868555695 0.139589304470785 no 2913 0.164514177664027 4091 776813
SGTC_2304 7443016 91.4 µM -0.97781877201113 0.139169088814641 no 2914 0.164081982466084 3980 939854
SGTC_395 anisomycin 6.25 µM -0.979940749682619 0.138659517276786 no 2915 0.163557683292901 4074 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1330 1469-0054 61.8 µM -0.980409296343497 0.138547172049092 no 2916 0.163442061365505 4075 7102664
SGTC_1366 1683-0113 21.9 µM -0.980773540340714 0.138459878729913 no 2917 0.163352214595232 4075 708623
SGTC_3067 9117431 49.47 µM -0.985253530449825 0.137389286820149 no 2918 0.162249776175261 4109 17150885
SGTC_1574 spiramycin 23.7 µM -0.986206993472038 0.137162167389494 no 2919 0.162015774088235 4043 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_676 falcarinol 140 µM -0.987030015716932 0.136966325930118 no 2920 0.161813962070553 4076 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2166 5933061 31.504 µM -0.987311062093789 0.13689949360109 no 2921 0.161745084655704 4185 2877375
SGTC_3253 9135987 49.47 µM -0.988473244783176 0.136623365287646 no 2922 0.16146046573737 4084 4182430
SGTC_1863 st057641 20.1 µM -0.988566532472132 0.136601217161786 no 2923 0.161437633719814 4091 3921635
SGTC_1434 4073-0095 163 µM -0.988929366925445 0.136515097275262 no 2924 0.161348850568777 4008 24133745
SGTC_2529 gangaleoidin 93.61 µM -0.989820793211669 0.136303672185769 no 2925 0.161130859805775 4105 4565183
SGTC_367 0335-0881 7.1 µM -0.990396507547987 0.136167245583388 no 2926 0.160990175911288 4058 23828853
SGTC_13 0199-0087 65 µM -0.99146049537042 0.13591535919218 no 2927 0.160730386578727 4136 4589825
SGTC_1896 st058441 89 µM -0.991686901863687 0.135861801355924 no 2928 0.160675141222135 4084 688759
SGTC_1156 4092-0367 4.88 µM -0.992473056978116 0.135675943793721 no 2929 0.160483408133179 4089 1357585
SGTC_1252 0493-0875 34.8 µM -0.993529306812978 0.135426506544455 no 2930 0.160226037856095 4066 3960963
SGTC_2016 5121758 140 µM -0.995492033795101 0.134963836427461 no 2931 0.159748508407241 4017 2795203
SGTC_555 4296-0685 37 µM -0.997334114989194 0.13453059326732 no 2932 0.159301179894048 4044 2908540 YHR072W ERG7
SGTC_1563 conessine 56.1 µM -0.997982626509576 0.134378295866432 no 2933 0.159143891641946 4156 441082 An anti-amoebic, histamine inhibitor.
SGTC_3104 9120930 49.47 µM -0.998402005490035 0.134279871345193 no 2934 0.159042230767262 4119 17014836
SGTC_1887 st057648 70.8 µM -0.999074407063778 0.134122168017592 no 2935 0.158879323975686 4092 688672
SGTC_2421 5690543 90.72 µM -1.00303205469365 0.133196530268934 no 2936 0.157922697720216 4104 3397993
SGTC_462 ag-879 158 µM -1.00394711739077 0.132983137277428 no 2937 0.157702051991728 4114 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1389 3405-0187 19 µM -1.00535580204832 0.132655091692268 no 2938 0.157362777031479 4056 799890
SGTC_2645 abamectin 100 µM -1.00754930031689 0.132145394222617 no 2939 0.156835439388707 4047 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_18 0111-0177 500 nM -1.00839023575259 0.13195034677826 no 2940 0.156633579300094 4161 721752
SGTC_1165 k072-0275 30.3 µM -1.008976587691 0.131814465247975 no 2941 0.156492931268285 4070 6153523 YGL055W OLE1
SGTC_1714 st033236 13.627 µM -1.01359872332461 0.130746708783531 no 2942 0.155387133559905 4153 2916566
SGTC_2265 7929201 200 µM -1.01454563046513 0.130528704365189 no 2943 0.155161233811487 4071 1265108
SGTC_880 0833-0487 87.2 µM -1.01575211983589 0.130251301237653 no 2944 0.154873720855268 4101 76075
SGTC_2020 4017018 200 µM -1.01633488264635 0.130117455184713 no 2945 0.154734971441226 4182 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1516 st013856 110 µM -1.01776718614792 0.129788895425969 no 2946 0.154394304825029 4155 5281404 A mutagen and neurotoxin.
SGTC_3136 9095672 49.47 µM -1.01825254498474 0.129677688158993 no 2947 0.154278977093914 3822 17217380
SGTC_3120 9124077 49.47 µM -1.02021327029874 0.129229111200746 no 2948 0.153813662671209 4213 18774327 YGL155W CDC43
SGTC_1229 0139-0193 12.2 µM -1.02206684398816 0.1288060386071 no 2949 0.153374632234113 4203 3090752
SGTC_1075 aripiprazole 15.2 µM -1.02545544345963 0.128035087031636 no 2950 0.152574169458566 4153 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2944 9067346 25.62 µM -1.02644278459938 0.127811058070387 no 2951 0.152341459866701 4072 6473075
SGTC_2206 7254556 146.969 µM -1.02735584929932 0.127604125111855 no 2952 0.152126466514338 4115 4398905
SGTC_3225 9130819 49.47 µM -1.02771683490543 0.127522377208869 no 2953 0.152041523204984 4050 4547121
SGTC_3185 9108267 49.47 µM -1.02860142704524 0.127322208646382 no 2954 0.151833503554408 4128 4910486
SGTC_2595 hexamethylquercetagetin 100 µM -1.02883342201404 0.127269748218884 no 2955 0.15177897920487 4097 386331
SGTC_630 4356-0227 183 µM -1.02889456008688 0.127255925727041 no 2956 0.151764612466403 4087 779312
SGTC_1520 flindersine 88 µM -1.0324245018108 0.126459623974876 no 2957 0.150936649351861 4222 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2592 piperlongumine 83.33 µM -1.03459634701676 0.125971416857948 no 2958 0.150428730348814 4142 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1504 k297-0033 30 µM -1.03637157231923 0.125573342894233 no 2959 0.150014413678434 4011 4388117
SGTC_2228 7354201 200 µM -1.0383265925227 0.12513596856844 no 2960 0.149559016150107 4176 753451
SGTC_3165 9101544 49.47 µM -1.04119728563671 0.124495671022727 no 2961 0.148891997616264 4145 5002184
SGTC_168 3970-0862 530.542 µM -1.04146701720301 0.124435626328715 no 2962 0.148829426585239 4098 3135186
SGTC_718 1130-0073 349 µM -1.0418632103992 0.124347466849601 no 2963 0.148737551459682 4177 6740020
SGTC_1697 st025554 27.742 µM -1.04304479309302 0.124084804760045 no 2964 0.148463773781461 4123 1269519
SGTC_3326 9140064 16.379 µM -1.04352202297698 0.12397882820562 no 2965 0.148353293214078 4051 1868434
SGTC_398 bronopol 33.3 µM -1.04452731190442 0.123755794956033 no 2966 0.148120744904483 4044 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_692 k241-0027 77.8 µM -1.04603794054216 0.123421175565009 no 2967 0.147771757877057 4202 3600480
SGTC_201 4262-0159 12.803 µM -1.04617263733378 0.123391369681141 no 2968 0.147740666839584 4174 1341029
SGTC_2202 7226349 200 µM -1.04623692115727 0.12337714664953 no 2969 0.147725830237111 4095 844334
SGTC_1905 st060207 84.5 µM -1.04722718539295 0.123158192171862 no 2970 0.147497404926821 4112 1948547
SGTC_713 1488-1073 324 µM -1.04816109512062 0.122951947738548 no 2971 0.147282195905763 4073 3312542
SGTC_1746 st038117 42 µM -1.05059899660603 0.122414703575199 no 2972 0.146721401055522 4192 2898218
SGTC_1783 st039459 87.517 µM -1.05083978359415 0.122361730502811 no 2973 0.146666090236893 4245 729761
SGTC_2774 tamoxifen 10.92 µM -1.05212396361825 0.122079482966174 no 2974 0.146371339485434 4132 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2722 naftopidil 47.16 µM -1.05231547405374 0.122037430449337 no 2975 0.146327417254154 4055 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_416 estradiol valerate 100 µM -1.05551629956706 0.121336087766628 no 2976 0.145594629432527 4186 13791 A steroid.
SGTC_180 1486-1293 102.781 µM -1.05607293056657 0.121214412511255 no 2977 0.145467448228155 4040 4140536
SGTC_1119 parthenolide 318.541 nM -1.05658918841713 0.121101639243232 no 2978 0.145349558442807 4258 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_327 1273-0057 3.96 µM -1.05806840154555 0.120778923245262 no 2979 0.145012129501934 4019 3108138
SGTC_2822 7994718 71.43 µM -1.05838383737702 0.120710183823404 no 2980 0.144940242499047 4130 1018011
SGTC_35 0133-0054 64.071 µM -1.05926093952707 0.120519191478654 no 2981 0.144740479330462 4169 99677
SGTC_443 clozapine 122 µM -1.0635926695947 0.119579061604039 no 2982 0.143756632298153 4102 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_128 0906-2981 13.371 µM -1.06444879398453 0.119393867958166 no 2983 0.143562719785278 4149 6740226
SGTC_623 k072-0108 16.9 µM -1.06707981090402 0.118826003112061 no 2984 0.142967898830668 4124 5382803
SGTC_2134 5324836 1.464 µM -1.06765791326217 0.118701484604407 no 2985 0.142837424792194 4116 699272
SGTC_1961 st076550 68.7 µM -1.0686942903546 0.11847848830238 no 2986 0.142603722575597 4189 1579337
SGTC_2608 thymoquinone 42.66 µM -1.06916482197324 0.118377342239608 no 2987 0.142497703458369 4162 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3131 9127911 49.47 µM -1.0721052910027 0.117746637920792 no 2988 0.141836371322273 4224 45595681
SGTC_2701 st077767 14.721 µM -1.07334916582689 0.117480554929486 no 2989 0.141557241700578 4133 5721188
SGTC_2838 9002687 71.43 µM -1.07431273046874 0.117274727219832 no 2990 0.141341270601887 4159 6457060
SGTC_804 1595-0054 20.9 µM -1.07480368162371 0.117169953085227 no 2991 0.141231315904239 4107 761523 Stimulates phospholipase C.
SGTC_2163 5671233 125 µM -1.07635254752181 0.116839843494459 no 2992 0.140884808008443 4141 701023
SGTC_1351 1496-0003 46.5 µM -1.07707286209618 0.116686547737631 no 2993 0.140723857909686 4192 3891978
SGTC_1484 3473-2379 286 µM -1.08198537120821 0.115644880544815 no 2994 0.139629514116172 4297 671917
SGTC_1716 st033144 30.6155 µM -1.0823440622362 0.115569081922743 no 2995 0.139549836985473 4202 674617
SGTC_1416 3966-0321 25.3 µM -1.08420695053587 0.115175983876523 no 2996 0.139136525301083 4220 582530 YLR208W SEC13
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.08445960091063 0.115122744059025 no 2997 0.139080534984599 4269 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_579 4491-1009 110 µM -1.08556101483927 0.114890852735588 no 2998 0.138836627787127 4294 1271041
SGTC_138 0850-0259 40.9225 µM -1.08633821824292 0.114727420659331 no 2999 0.138664692136365 4121 6813004
SGTC_2686 alizarin 95.37 µM -1.0872060601062 0.114545124479771 no 3000 0.138472876603447 4177 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1807 st050092 58.9 µM -1.0903781512824 0.113880559056403 no 3001 0.13777330108684 4205 5008496
SGTC_2104 5389443 200 µM -1.09043049889478 0.113869615121315 no 3002 0.137761776566164 4226 2244536
SGTC_2156 5649887 115 µM -1.09162838515231 0.113619386516909 no 3003 0.137498237217656 4222 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3180 9109287 49.47 µM -1.09364632438325 0.113198742479846 no 3004 0.137055061922404 4232 18891271
SGTC_2824 7998404 51.95 µM -1.1024036735692 0.11138612823432 no 3005 0.135143107590063 4166 837851
SGTC_423 5-fluorouracil 457 µM -1.10337588428929 0.111186186549832 no 3006 0.134931982434013 4127 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2413 inermin 26.06 µM -1.10345635102087 0.1111696495465 no 3007 0.134914518432093 4279 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1794 st048918 76.9 µM -1.10369046741283 0.111121545472941 no 3008 0.134863716076383 4121 672303
SGTC_2215 7188065 200 µM -1.1045321351109 0.11094873049056 no 3009 0.134681185834372 4227 940217
SGTC_1328 1441-0025 69.2 µM -1.10471153791634 0.11091191960706 no 3010 0.134642301153946 4172 4562601
SGTC_101 0490-5701 117.494 µM -1.10604280299552 0.110639036420549 no 3011 0.134353996687991 3982 4661669
SGTC_491 tetrandrine 80.3 µM -1.10701759685911 0.110439528226562 no 3012 0.134143160186071 4207 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_20 0481-0013 4.944 µM -1.10973517194944 0.109884692341498 no 3013 0.133556580994422 4230 182045
SGTC_1548 st061468 90.8 µM -1.11007762039384 0.109814918255964 no 3014 0.133482790015826 4195 390799
SGTC_1127 asiatic acid 681.4 nM -1.11034228973302 0.109761013502213 no 3015 0.133425778135923 4147 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1700 st030840 7.9285 µM -1.11073924369744 0.109680202174008 no 3016 0.133340302499058 4251 5499307
SGTC_2250 alverine citrate 130 µM -1.11174447603419 0.1094757494592 no 3017 0.13312401550202 4089 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1052 3253-3998 198 µM -1.11685814635361 0.108439924960901 no 3018 0.132027491221213 4143 5450317
SGTC_3264 9137442 49.47 µM -1.11691041153261 0.108429374661183 no 3019 0.132016316249868 4208 17015726
SGTC_3316 9136639 10.545 µM -1.11718656048982 0.108373643224649 no 3020 0.131957282859178 4212 4903665
SGTC_3034 9090421 49.47 µM -1.12160610557736 0.107484509117179 no 3021 0.131014977251795 4118 17173761
SGTC_1452 4194-0072 190 µM -1.1282913160226 0.106149573683129 no 3022 0.129598454856419 4286 1343545
SGTC_176 1486-1328 72.834 µM -1.12894967882082 0.106018759301526 no 3023 0.129459531067363 4293 22310231
SGTC_2591 skatole 100 µM -1.12978974608588 0.105852010077886 no 3024 0.129282414964257 4253 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_821 1114-0266 29.2 µM -1.13071936165027 0.105667706999202 no 3025 0.129086614729792 4227 3123235
SGTC_2940 9060638 45.86 µM -1.1309868522162 0.105614718050317 no 3026 0.129030312654765 4213 4027022
SGTC_2736 butenafine 14.65 µM -1.13169183629301 0.105475155218496 no 3027 0.128882007451718 4154 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1488 4013-0813 75.9 µM -1.13180806163117 0.105452159374523 no 3028 0.128857568863421 4159 2910057
SGTC_1546 5-methoxyflavanone 78.7 µM -1.13226664939115 0.105361460560641 no 3029 0.128761173426833 4228 147795
SGTC_3245 9134821 49.47 µM -1.13245213861417 0.105324790808124 no 3030 0.128722197688752 4242 17014901
SGTC_2974 9094440 9.66 µM -1.13332198881186 0.105152951473167 no 3031 0.128539530485383 4233 25236134
SGTC_1006 4099-6547 255 µM -1.13400641270898 0.10501788588665 no 3032 0.128395929047365 4248 3146833
SGTC_1641 st009299 47.1 µM -1.13471585835438 0.104878015052313 no 3033 0.128247195301961 4161 4046054
SGTC_2375 9072683 200 µM -1.13802862902887 0.104226670648042 no 3034 0.12755426401455 4308 16798029
SGTC_452 diindolylmethane 8 µM -1.13829311653034 0.104174794793877 no 3035 0.127499053667722 4229 3071 Inhibits expression of several cancer promoting factors.
SGTC_1455 4262-0120 131 µM -1.13845741507954 0.104142579152668 no 3036 0.127464765595707 4292 1529587
SGTC_2911 7942208 15.64 µM -1.13925428002135 0.103986432424456 no 3037 0.127298555876428 4266 1243384
SGTC_148 3253-0744 288.01 µM -1.14054639631127 0.103733601496557 no 3038 0.127029367401347 4108 6893655
SGTC_399 oxolinic acid 75 µM -1.15187850041726 0.101535313330005 no 3039 0.12468550204961 4206 4628 A DNA gyrase inhibitor.
SGTC_666 0272-0154 136 µM -1.15274753206294 0.101368143311126 no 3040 0.124507012799807 4247 6870312
SGTC_1312 1218-2183 165 µM -1.15348844902898 0.1012257763069 no 3041 0.124354977993017 4293 6744073
SGTC_738 1315-0003 72.4 µM -1.15361480912579 0.101201510796755 no 3042 0.12432906209694 4278 6251474
SGTC_758 0868-0029 16 µM -1.15393703341207 0.101139651772955 no 3043 0.124262992421458 4248 762687
SGTC_1295 1013-0063 9.78 µM -1.15416552812653 0.101095803189979 no 3044 0.124216156176561 4274 6826038
SGTC_1301 naphtanilide LB 4.81 µM -1.15534906325203 0.100868902220729 no 3045 0.123973755901694 4311 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_545 4218-0007 221 µM -1.15815782755212 0.100331907793443 no 3046 0.123399817414187 4223 2840508
SGTC_1460 k062-0059 9.15 µM -1.15875848295608 0.100217342605575 no 3047 0.123277322413042 4127 1373085
SGTC_1331 1472-0049 76.2 µM -1.1598736952884 0.100004887395209 no 3048 0.123050116960434 4193 24051409
SGTC_2226 7298446 200 µM -1.16054395334948 0.0998773572082913 no 3049 0.122913704646522 4248 3283010
SGTC_2243 6634756 200 µM -1.16075581460199 0.0998370710269846 no 3050 0.122870608267423 4305 885676
SGTC_2495 cafestol 54.53 µM -1.16142832565186 0.0997092692653772 no 3051 0.122733877660374 4266 16667697 An anti-infammatory.
SGTC_2232 chlorophetanol 41.5365 µM -1.16176744920003 0.099644868706798 no 3052 0.122664969739569 4311 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.16269359748578 0.0994691452796671 no 3053 0.122476920104885 4248 140250 A respiratory chain inhibitor.
SGTC_2147 5545932 89.7195 µM -1.16531225221637 0.0989735187001491 no 3054 0.121946310699786 4288 797404
SGTC_3053 9095903 49.47 µM -1.16653257876791 0.0987431684889063 no 3055 0.121699592272286 4371 17174018
SGTC_2449 5812982 45.77 µM -1.17076209762475 0.0979478364179506 no 3056 0.120847208417625 4188 776185
SGTC_2461 5755302 26.15 µM -1.17443257013738 0.0972614427296651 no 3057 0.120110902923333 4300 2788904
SGTC_801 0866-0028 10.1 µM -1.17798480905796 0.0966005262089649 no 3058 0.119401331191675 4284 6849771
SGTC_852 0418-0143 439 µM -1.18433700521397 0.0954268949071631 no 3059 0.118139842920782 4273 5369229
SGTC_1288 0973-0013 65.5 µM -1.18608578005026 0.0951056414998051 no 3060 0.117794212787637 4292 4315430
SGTC_432 NS 1619 61.3 µM -1.1871078923858 0.094918246638581 no 3061 0.117592532816296 4267 4552 A K+/calcium channel activator.
SGTC_1665 st014639 11.4 µM -1.19153455693776 0.0941097983671092 no 3062 0.116721899432482 4337 981133 YIL048W NEO1
SGTC_1184 1269-1718 139 µM -1.19253928590264 0.0939270126962949 no 3063 0.116524928026496 4322 5403821
SGTC_1054 3429-0080 167 µM -1.19424797981333 0.0936167598585011 no 3064 0.116190489896552 4307 1162877
SGTC_1747 st037496 66.6 µM -1.19459792131981 0.0935533133624267 no 3065 0.116122080896702 4249 723305
SGTC_1851 st056236 18.9 µM -1.19489471319366 0.0934995281050854 no 3066 0.116064084364523 4279 5393171
SGTC_2132 5317594 122.667 µM -1.19599571087677 0.0933002024533562 no 3067 0.115849116426108 4231 794577
SGTC_962 1254-0300 21.5 µM -1.19622216837954 0.0932592433313071 no 3068 0.115804936060581 4238 7340576
SGTC_616 4092-0450 108 µM -1.19807037747677 0.0929254563441735 no 3069 0.115444809933639 4283 787165
SGTC_1845 st056753 3.01 µM -1.20174865414492 0.0922637882254475 no 3070 0.114730462163752 4262 5375839
SGTC_1266 0828-0227 32.9 µM -1.2049679225225 0.0916875561008322 no 3071 0.114107842727113 4263 3913820
SGTC_2266 7929956 200 µM -1.20535433199892 0.0916185704619881 no 3072 0.114033271672412 4230 2967153
SGTC_78 0336-0123 156.75 µM -1.20699668332171 0.0913257907704496 no 3073 0.113716710637067 4128 6765896
SGTC_2715 st079500 56.4 µM -1.20700903271514 0.0913235918917239 no 3074 0.113714332683042 4260 28246688
SGTC_1646 st011709 75.6 µM -1.20975804279243 0.0908350915098056 no 3075 0.113185875186901 4254 5757843
SGTC_1076 itraconazole 331 nM -1.21542997478058 0.0898333183058849 no 3076 0.112101070693221 4296 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1514 1189-1591 158 µM -1.21732416326067 0.0895006037126006 no 3077 0.111740452149323 4307 767698 YMR146C TIF34
SGTC_1675 st018485 24.5 µM -1.21780597646709 0.0894161195136526 no 3078 0.111648856330722 4331 3323024
SGTC_3040 9091894 49.47 µM -1.21992126185407 0.0890459136967067 no 3079 0.111247362441501 4149 25236966
SGTC_1125 tnp00248 1.32998 µM -1.22336486786477 0.0884456746288804 no 3080 0.110595958279988 4347 24207736
SGTC_879 0831-1030 162 µM -1.22401009041374 0.088333544993382 no 3081 0.110474210534217 4314 1549252
SGTC_1968 st069590 43.6 µM -1.22448566872155 0.088250964730235 no 3082 0.110384534676347 4266 6384066
SGTC_3108 9121785 49.47 µM -1.22654446656427 0.087894135062339 no 3083 0.109996926302216 4126 17140271
SGTC_2179 6298986 200 µM -1.2271217843599 0.0877942681060494 no 3084 0.109888410630519 4291 738374
SGTC_2643 anethole 100 µM -1.22760777670815 0.0877102646610566 no 3085 0.109797120544123 4296 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2227 7312221 64.1025 µM -1.23020313932433 0.0872626729442597 no 3086 0.109310522300944 4420 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_334 1502-1024 68.5 µM -1.23166437535985 0.0870114222406483 no 3087 0.109037241316926 4317 3296216
SGTC_1166 k206-0078 225 µM -1.23244552627474 0.0868773298977282 no 3088 0.108891351721036 4324 5404595
SGTC_1682 st012968 530 nM -1.23280866061831 0.0868150468604444 no 3089 0.108823579692445 4316 24207270
SGTC_3337 9144342 33.5465 µM -1.23758384797769 0.0859991313434902 no 3090 0.107935203260809 4308 17682949
SGTC_310 1273-0058 1.06 µM -1.23997140907129 0.085593337076105 no 3091 0.107492984696932 4111 2734232
SGTC_1479 0549-0158 134 µM -1.24040918141508 0.0855190882832229 no 3092 0.107412043372771 4384 5440202
SGTC_187 1488-2104 32.728 µM -1.24044594319174 0.0855128554632358 no 3093 0.107405248353893 4316 2852859
SGTC_3213 9129884 49.47 µM -1.24446345120264 0.0848337504195959 no 3094 0.106664521390637 4305 17190742
SGTC_2741 miltefosine 3.04 µM -1.24829816004756 0.0841893245978806 no 3095 0.10596094388637 4350 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1572 epiandrosterone 68.9 µM -1.25065015811601 0.0837958915720824 no 3096 0.105531071131141 4261 441302 A steroid.
SGTC_477 mead ethanolamide 10 µM -1.25596750732732 0.0829115188913643 no 3097 0.10456387546956 4269 16061185
SGTC_2359 9039622 200 µM -1.26124094391861 0.0820414026651743 no 3098 0.103611025578904 4299 6463596
SGTC_2996 9066192 71.4286 µM -1.26425907648857 0.0815465165127106 no 3099 0.103068526459005 4350 6472854
SGTC_2003 4023581 200 µM -1.26769791463473 0.0809853942465291 no 3100 0.102452924900736 4353 16641307
SGTC_939 1165-0479 45.3 µM -1.27006697361866 0.0806005287977799 no 3101 0.102030387323502 4326 1377347
SGTC_885 0865-0106 16.8 µM -1.27028045914226 0.0805659149779312 no 3102 0.101992373120303 4297 2793380
SGTC_1199 1638-0010 4.46 µM -1.27066191828716 0.0805040944412553 no 3103 0.101924474432826 4314 3111136
SGTC_2290 7904846 200 µM -1.27078746967739 0.0804837550060034 no 3104 0.101902133824985 4366 2962154
SGTC_291 SEC14.278 35.5 µM -1.27334208719458 0.0800707473839483 no 3105 0.101448339064544 4379 1068044
SGTC_520 3584-0023 682 µM -1.27459293917319 0.0798691061280823 no 3106 0.101226678975935 4361 1340790
SGTC_1195 1502-0147 41.1 µM -1.2798361172518 0.0790280663316607 no 3107 0.100301389337279 4350 817940
SGTC_597 k018-0003 82.8 µM -1.28097930855551 0.0788455849139076 no 3108 0.100100466977113 4419 6786234
SGTC_2854 9024559 71.43 µM -1.28113914306565 0.0788200968565692 no 3109 0.100072398586168 4364 3163529
SGTC_2297 7971671 152.32 µM -1.28117260298988 0.078814761950162 no 3110 0.100066523447209 4351 909016
SGTC_1051 3253-3903 78 µM -1.28165514933967 0.078737854371274 no 3111 0.0999818224233268 4340 5509239
SGTC_1919 st067113 52.3 µM -1.28402266650791 0.0783613464604781 no 3112 0.0995670123078669 4359 1268243
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.28446528285447 0.0782911085901692 no 3113 0.0994896017220561 4368 4174840
SGTC_2216 7189485 200 µM -1.28614835789265 0.0780244607970999 no 3114 0.0991956450120365 4353 731273
SGTC_3004 9076122 71.4286 µM -1.2870363349527 0.0778840574750971 no 3115 0.0990408119581494 4358 44782551
SGTC_253 dyclonine 31.25 µM -1.28731896303694 0.07783940971991 no 3116 0.0989915683210983 4460 3180 An oral anasthetic.
SGTC_2541 muurolladie-3-one 83.07 µM -1.29355508709552 0.0768592031127693 no 3117 0.0979095722688839 4307 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2812 7970281 58.44 µM -1.2979042172745 0.0761811719246171 no 3118 0.0971601253587508 4394 2233435
SGTC_2429 5902844 64.44 µM -1.29897847266916 0.0760143983034509 no 3119 0.0969756585440754 4357 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.30044207205372 0.0757876281982571 no 3120 0.0967247490870874 4434 5282309
SGTC_1852 st056254 31.4 µM -1.31445065438118 0.0736431372157068 no 3121 0.0943472968249991 4334 442583
SGTC_3350 9150499 3.57 µM -1.32192662552922 0.0725178320437438 no 3122 0.093096292649032 4381 4910996 YPR165W RHO1
SGTC_2236 dapsone 200 µM -1.32506250940984 0.0720497497494029 no 3123 0.0925752097248257 4391 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_782 0083-0095 30.5 µM -1.32777066157474 0.0716473804173768 no 3124 0.0921269409290574 4339 3591729 An indicator and reagent.
SGTC_1323 1348-1351 11.2 µM -1.32868547958844 0.0715118496640852 no 3125 0.091975878718402 4374 6989654
SGTC_2864 9034755 47.6 µM -1.32888601522646 0.0714821665138005 no 3126 0.0919427891637375 4313 4930451
SGTC_174 3553-0389 74.3 µM -1.33078325346632 0.0712018062844274 no 3127 0.0916301698955877 4440 738071
SGTC_2150 5556613 200 µM -1.33095698326402 0.0711761759963958 no 3128 0.0916015828107366 4423 743190
SGTC_3255 9139072 49.47 µM -1.33177016057812 0.0710563024402992 no 3129 0.0914678630607247 4387 17646060
SGTC_796 1234-0020 70.7 µM -1.34065056267801 0.0697572813256336 no 3130 0.0900169663014376 4325 46495034
SGTC_2162 5663267 200 µM -1.34403366290521 0.0692672394318389 no 3131 0.0894687507945515 4406 6456493
SGTC_2043 5101342 149 µM -1.34461194607294 0.069183741198687 no 3132 0.0893752917573992 4420 678451
SGTC_2023 5144124 124 µM -1.3480738680422 0.0686854956494091 no 3133 0.0888173126849067 4386 2830192
SGTC_1021 4476-0760 85.3 µM -1.34923612957999 0.0685188429401516 no 3134 0.0886305666955809 4425 746768
SGTC_887 0885-0007 9.62 µM -1.35645351973054 0.0674909398707546 no 3135 0.0874774572935818 4440 5719458
SGTC_1618 st003135 44.5 µM -1.35734965332392 0.0673641483218305 no 3136 0.0873350686794555 4380 1270615
SGTC_2041 5107442 45.335 µM -1.35839150221826 0.0672169714519731 no 3137 0.0871697446358281 4439 793005
SGTC_1314 1222-0010 41.1 µM -1.3598870287542 0.0670061405016576 no 3138 0.0869328381719554 4413 3526027
SGTC_130 0136-0219 337.655 µM -1.36286700619846 0.0665875653505067 no 3139 0.0864622143473111 4241 234244
SGTC_1201 1889-3372 45.9 µM -1.36590712358885 0.0661626312677825 no 3140 0.0859840582818097 4305 5392199
SGTC_752 1896-0090 130 µM -1.36819799072538 0.0658438141641919 no 3141 0.0856250551913846 4402 772567
SGTC_577 r071-0003 38.6 µM -1.37032854247928 0.0655483777688227 no 3142 0.0852921835513907 4381 4568517 YMR134W ERG29
SGTC_2936 9038235 15.59 µM -1.37966708566946 0.0642655460650324 no 3143 0.0838445857797438 4344 4749415
SGTC_3270 9137563 49.47 µM -1.38274847929663 0.0638465649402977 no 3144 0.0833710006869522 4410 17015724
SGTC_691 1548-0686 185 µM -1.38817987275206 0.0631132277365675 no 3145 0.0825411397780312 4404 46495133
SGTC_1683 st010134 710 nM -1.39348440958922 0.0624033666369955 no 3146 0.0817366781406492 4399 3818134
SGTC_1362 1611-0397 101 µM -1.39503058411773 0.0621976313798859 no 3147 0.0815033084875979 4412 27816
SGTC_901 1112-0062 60.1 µM -1.39787756360046 0.0618201944066137 no 3148 0.0810749186236314 4415 1908457
SGTC_704 1310-0270 142 µM -1.40025906614408 0.0615058431366598 no 3149 0.080717876950469 4427 5718033
SGTC_2152 5568786 200 µM -1.40081138536027 0.0614331172837322 no 3150 0.0806352415480794 4454 5399883
SGTC_920 mycophenolic acid 780.421 nM -1.40995255392382 0.0602391976306792 no 3151 0.079276846555415 4413 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.41598014819026 0.059461928278393 no 3152 0.0783906584204621 4435 6708760
SGTC_1443 4112-3303 14 µM -1.41630326782656 0.0594204844606831 no 3153 0.0783433657441692 4485 704433
SGTC_1163 k060-0048 49.9 µM -1.41730091178496 0.0592926680017997 no 3154 0.0781974843554816 4456 6809982
SGTC_251 melphalan 456.522 µM -1.41832526048581 0.0591616545920513 no 3155 0.0780479125153867 4484 460612 A DNA alkylator.
SGTC_2754 granisetron 64.02 µM -1.42196463655538 0.0586980167466802 no 3156 0.0775182586404623 4448 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_481 bay k-8644 50 µM -1.42268022507765 0.0586071908528845 no 3157 0.0774144378491616 4416 2303 A calcium channel antagonist.
SGTC_2294 7971431 200 µM -1.42340445209085 0.0585153808954074 no 3158 0.0773094713086187 4433 5741572
SGTC_80 0159-0065 512.242 µM -1.42467138369375 0.0583550441158273 no 3159 0.0771261074027204 4391 1548079
SGTC_979 1426-2828 121 µM -1.42624384124246 0.0581565215875814 no 3160 0.0768989843705041 4524 747872
SGTC_795 0685-0265 78 µM -1.43196049074511 0.057439263649271 no 3161 0.0760775643727619 4455 302754
SGTC_2124 5246320 200 µM -1.43201226712495 0.0574327993047605 no 3162 0.0760701553168065 4460 579342
SGTC_1167 k781-0610 148 µM -1.43327200628269 0.0572756956258869 no 3163 0.0758900593691682 4485 4525169
SGTC_3335 9143315 29.6265 µM -1.43743095096507 0.0567594286098266 no 3164 0.0752977897693811 4463 4899691
SGTC_2001 4023502 57.655 µM -1.44026005206477 0.0564103403068259 no 3165 0.0748969194657395 4467 108941 YCR052W RSC6
SGTC_1632 st005650 90 µM -1.44195437570177 0.0562020859747374 no 3166 0.07465762245561 4475 2759605
SGTC_2264 7948757 110.76 µM -1.44285764070197 0.0560913109890954 no 3167 0.0745302889167413 4439 2971411
SGTC_1677 st019204 53.9 µM -1.44301551155514 0.0560719676473417 no 3168 0.0745080508441776 4461 3945625
SGTC_3156 9099931 49.47 µM -1.44788401081573 0.0554780267494539 no 3169 0.0738247460314706 4509 18111053
SGTC_3088 9117578 49.47 µM -1.44979067520497 0.0552467779119947 no 3170 0.0735584503139486 4529 678341
SGTC_368 fentichlor 4.58 µM -1.45198033168315 0.0549821464545154 no 3171 0.0732535370771165 4468 7329 A pesticide.
SGTC_389 tpck 16.7 µM -1.45300926039103 0.0548581414442033 no 3172 0.0731105914397059 4502 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2618 avocadyne 43.43 µM -1.45524391758337 0.0545895851783762 no 3173 0.0728008732730729 4401 3015189
SGTC_1102 cgs 12066b 26.1 µM -1.45843547186804 0.0542078350291342 no 3174 0.0723602746502049 4475 6438352 A 5-HT1B full agonist.
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.4621600472086 0.0537650034079318 no 3175 0.0718486785382463 4422 97141
SGTC_261 5-fluorouridine 15.376 µM -1.46400917510846 0.0535462189884794 no 3176 0.0715957207218938 4493 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_744 1594-0068 283 µM -1.46666052649765 0.0532337488147226 no 3177 0.0712342129871906 4465 668392
SGTC_2440 5628896 157.78 µM -1.46763573525213 0.0531191816360787 no 3178 0.0711015978472533 4444 5522048
SGTC_1113 artemisinin 1.17947 µM -1.46800021081787 0.0530764133956919 no 3179 0.0710520828208901 4512 2240 An anti-malaria and mitochondrial poison.
SGTC_3085 9117376 49.47 µM -1.46807209598692 0.0530679814808774 no 3180 0.0710423201466322 4550 16480349
SGTC_1056 3448-1962 115 µM -1.46903993431419 0.0529545603380911 no 3181 0.0709109789905191 4439 715507
SGTC_783 0848-0141 92.7 µM -1.47124886739174 0.0526964152345391 no 3182 0.0706119129767614 4412 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_840 0245-0196 390 µM -1.47526261419024 0.052229908631191 no 3183 0.0700709767122607 4546 3827528
SGTC_3355 9151058 44.0485 µM -1.47705430711861 0.0520227267511233 no 3184 0.0698305402304095 4505 17015728
SGTC_2091 4-phenylthiadiazole 200 µM -1.48004809232174 0.0516779988008673 no 3185 0.069430206348138 4500 270010
SGTC_1159 4092-0538 61.2 µM -1.48083260331674 0.051587964978487 no 3186 0.0693255930922421 4507 717301
SGTC_1934 st074720 32.6 µM -1.48315430327234 0.0513222473484 no 3187 0.0690167095334486 4424 17250992
SGTC_112 phenothiazine 287.218 µM -1.48707938321574 0.0508755008795031 no 3188 0.068496922997556 4453 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_889 0919-1524 82.7 µM -1.48803409281207 0.0507673067868088 no 3189 0.0683709514340429 4497 3905452
SGTC_1278 0874-0585 172 µM -1.48975193775425 0.0505730905853378 no 3190 0.0681447363480641 4532 766306
SGTC_2727 riluzole 51.77 µM -1.49009375672236 0.0505345158912516 no 3191 0.0680997927785845 4528 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_831 k061-1017 217 µM -1.49089485322246 0.0504442029953144 no 3192 0.067994551429288 4534 1240153
SGTC_1057 3448-5381 134 µM -1.49624215412459 0.0498446562173191 no 3193 0.0672952815900601 4462 5497911
SGTC_3080 9117754 49.47 µM -1.49629182654259 0.0498391136394237 no 3194 0.0672888120577301 4491 9550191
SGTC_3292 9120825 59.784 µM -1.49710873440281 0.0497480314370665 no 3195 0.067182483707837 4456 24824900
SGTC_430 0958-0115 16.4 µM -1.49742838007779 0.0497124282944896 no 3196 0.0671409141539143 4431 6833180
SGTC_1773 st048542 73.5835 µM -1.4982986558614 0.0496155972500973 no 3197 0.0670278365774122 4481 3237138
SGTC_3186 9110464 49.47 µM -1.50009642582092 0.0494160453797638 no 3198 0.0667947133315335 4489 17018021
SGTC_1274 0865-0114 173 µM -1.50171494114373 0.0492369392501228 no 3199 0.0665853717647515 4485 870624
SGTC_2852 9023854 51.95 µM -1.50771568088296 0.0485774124819112 no 3200 0.0658136552216957 4499 19798528
SGTC_808 0711-0032 135 µM -1.50947796249228 0.0483850719221887 no 3201 0.0655883414291605 4470 4252555
SGTC_3141 9094609 49.47 µM -1.51142039483314 0.0481737753854517 no 3202 0.065340688185115 4462 25236309 YDL196W YDL196W
SGTC_2438 5259590 200 µM -1.51155696855826 0.0481589468071933 no 3203 0.0653233028501987 4511 1201127
SGTC_2059 5238311 157 µM -1.51170772357775 0.048142582726954 no 3204 0.0653041164553737 4464 703021
SGTC_1439 4092-1168 46 µM -1.51505897391756 0.0477799603339821 no 3205 0.0648787350114879 4512 2886240
SGTC_1363 1636-0063 10.4 µM -1.51873812881347 0.0473843789449891 no 3206 0.064414212533011 4508 6072185
SGTC_1190 1486-1332 13 µM -1.51875375892511 0.0473827040164549 no 3207 0.0644122446346862 4495 4150046
SGTC_2117 5521686 200 µM -1.52374068960646 0.0468507203113814 no 3208 0.0637867503607361 4497 803312
SGTC_2826 7992541 19.48 µM -1.52451920272173 0.0467681059719177 no 3209 0.0636895318345638 4507 2985066
SGTC_163 TUB2.036 7.546 µM -1.5273741694264 0.0464661419578719 no 3210 0.063333997888282 4459 15992207 YJR013W GPI14
SGTC_2443 5493264 126.67 µM -1.53271907838653 0.0459050304933207 no 3211 0.0626725431766857 4540 5340055
SGTC_2313 7726885 200 µM -1.53696273560945 0.0454634173688908 no 3212 0.0621512175195296 4522 726423
SGTC_465 cgp-37157 41 µM -1.53792947853129 0.0453632932973666 no 3213 0.0620329293380912 4565 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3356 9151811 4.48 µM -1.53846617047937 0.0453077855488929 no 3214 0.0619673369610239 4540 1859254 YPR165W RHO1
SGTC_2293 7624732 200 µM -1.54108036897405 0.0450381909705104 no 3215 0.0616486135034631 4409 894453
SGTC_1987 st072290 61.9 µM -1.54649924845979 0.0444834699506136 no 3216 0.0609920207236906 4551 54697379
SGTC_2480 5767542 37.17 µM -1.54694575671826 0.0444380082533217 no 3217 0.0609381630914793 4447 2867358
SGTC_2856 9022925 19.48 µM -1.5483664707653 0.044293605803987 no 3218 0.060767044516834 4524 4944862
SGTC_489 paxilline 115 µM -1.5496227941993 0.0441662274423863 no 3219 0.0606160393281883 4483 105008 A toxic potassium channel blocker.
SGTC_1731 st035964 63 µM -1.55217340219737 0.0439085302382603 no 3220 0.0603103692230633 4438 6739575
SGTC_2780 5215298 71.43 µM -1.55325373263568 0.043799746767885 no 3221 0.0601812644771235 4532 2834131
SGTC_3228 9131799 49.47 µM -1.55896370267479 0.0432283898381108 no 3222 0.0595024856896641 4548 17015818
SGTC_2089 5281248 129.67 µM -1.56115594840667 0.0430106325248462 no 3223 0.0592434799635459 4507 2737878
SGTC_3021 9087658 49.47 µM -1.56457599513857 0.0426726874614944 no 3224 0.058841180541938 4540 25237042
SGTC_2830 7992007 71.43 µM -1.57136208477912 0.0420084900117526 no 3225 0.0580492838331226 4429 1952075
SGTC_450 aminopyrene 156 nM -1.57496792393499 0.0416589831710714 no 3226 0.0576319243173421 4501 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1018 4259-0013 28.1 µM -1.5800344808258 0.0411718757361603 no 3227 0.0570494851252307 4570 6801262
SGTC_2153 5569715 200 µM -1.58131737481624 0.041049271598136 no 3228 0.0569027444213524 4556 2054701
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.58693533272663 0.0405158552002901 no 3229 0.0562636457771886 4552 15053
SGTC_3153 9100258 49.47 µM -1.58869541687656 0.0403499003144745 no 3230 0.0560645870823313 4463 25236848
SGTC_2106 5357045 167.29 µM -1.59970386366016 0.0393244193204814 no 3231 0.0548321471722163 4572 668842
SGTC_2394 5221648 200 µM -1.60876291895418 0.0384965276213107 no 3232 0.0538340959678356 4571 788586
SGTC_933 2914-0560 114 µM -1.60911152163778 0.0384649554426143 no 3233 0.0537959791797711 4559 463887
SGTC_886 0866-0150 153 µM -1.60923755340558 0.0384535462181149 no 3234 0.0537822039212494 4569 271463
SGTC_1463 k081-0032 34.1 µM -1.60924257418778 0.0384530917610283 no 3235 0.0537816552081639 4065 977755
SGTC_3098 9119039 49.47 µM -1.62810113345609 0.0367767421916645 no 3236 0.0517517216310541 4545 17161528
SGTC_3208 9114115 49.47 µM -1.63532625874561 0.0361505407791239 no 3237 0.0509903358692264 4520 650895
SGTC_2622 2-methoxyxanthone 59.94 µM -1.6375158970557 0.0359624980069047 no 3238 0.0507613600319644 4519 71034 A hepatoprotective.
SGTC_1503 4585-0012 61.3 µM -1.64074100558002 0.0356869904852666 no 3239 0.0504255945192639 4583 2922052
SGTC_1761 st044296 37 µM -1.64376935916624 0.0354298680092129 no 3240 0.0501119264090176 4574 1826700
SGTC_1981 st071826 47 µM -1.64749238705199 0.0351158480062448 no 3241 0.0497284398653401 4599 11838600
SGTC_2229 7354935 190 µM -1.65395648678667 0.0345760579637361 no 3242 0.0490681770796741 4561 318112
SGTC_1703 st026983 48.3 µM -1.65755022863968 0.0342789195022923 no 3243 0.0487041413392802 4599 1104023
SGTC_1638 st008370 60.6 µM -1.66027203000635 0.0340552744314048 no 3244 0.0484298699337296 4521 24207134
SGTC_2343 7990716 14.84 µM -1.66688696081817 0.0335167368185455 no 3245 0.0477684420635958 4584 6456862
SGTC_1867 st057372 64 µM -1.67272451855221 0.03304732864892 no 3246 0.0471907700865166 4557 688837
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.68119793845982 0.0323756163875259 no 3247 0.0463622369097 4608 94937 An inhibitor of serotonin biosynthesis.
SGTC_3016 9080866 49.47 µM -1.68408583283115 0.0321492747846698 no 3248 0.0460825409458514 4565 17066299
SGTC_2564 betulinic acid 100 µM -1.69265417960358 0.0314853982578315 no 3249 0.0452606558714603 4572 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.70019209385034 0.0309107684044876 no 3250 0.0445473994587919 4612 66535 A nucleotide analog.
SGTC_1594 piperine 70.1 µM -1.70391343424934 0.0306302997333855 no 3251 0.0441986304070627 4575 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1063 disulfiram 1.84 µM -1.71208349588714 0.0300219296168761 no 3252 0.0434406411953068 4614 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1423 4048-0112 5.59 µM -1.72475286341121 0.0290983658753312 no 3253 0.0422860098840948 4641 X1423
SGTC_2909 7941780 10.49 µM -1.73030849137851 0.0287008856845117 no 3254 0.0417875866223653 4561 1243215
SGTC_1686 st019653 115.5 µM -1.73168190735507 0.0286033230448215 no 3255 0.0416651068659534 4594 97252
SGTC_860 0443-0016 25.1 µM -1.73303361657158 0.0285075718679023 no 3256 0.0415448469858844 4605 5337942
SGTC_659 k018-0002 107 µM -1.73549527539875 0.0283338800645867 no 3257 0.0413265588070518 4583 6797879 YHR007C ERG11
SGTC_511 blebbistatin 171 µM -1.73864359384395 0.0281130227048366 no 3258 0.0410487367150527 4638 3476986 A myosin inhibitor.
SGTC_271 rotenone 740 µM -1.74076725142746 0.027964857226309 no 3259 0.0408621922694028 4636 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2663 amphotericin b 100 µM -1.74373667451093 0.027758774524631 no 3260 0.0406025086015158 4625 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_701 4424-0219 185 µM -1.74395591244595 0.0277436093581347 no 3261 0.0405833889032849 4609 2911779
SGTC_627 1391-0720 175 µM -1.74809002978753 0.0274589335158599 no 3262 0.0402242195755954 4602 997839
SGTC_1185 1319-0113 81.3 µM -1.74884208526581 0.027407409610094 no 3263 0.0401591599065809 4643 4672763
SGTC_647 0140-0236 81 µM -1.7534185160649 0.0270956099462005 no 3264 0.0397650975047929 4629 990837
SGTC_857 0438-0306 1.35 µM -1.75685511708237 0.0268634195064911 no 3265 0.0394712537870411 4643 4686136
SGTC_2217 6934799 96.0675 µM -1.76377433554572 0.0264009671172924 no 3266 0.0388849900281042 4591 675606
SGTC_1973 st070275 50.2 µM -1.77088439372803 0.0259327100608562 no 3267 0.0382899640269944 4609 17118334
SGTC_1309 pyrazolanthrone 13.4 µM -1.77129743828321 0.0259057225183466 no 3268 0.0382556266168514 4611 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1436 4092-1007 8.32 µM -1.78113699428082 0.0252697394323754 no 3269 0.0374450367389155 4633 2881121
SGTC_1788 fluconazole 20 µM -1.78472573806298 0.0250410592129318 no 3270 0.0371529070024304 4615 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2720 fluspirilene 36.88 µM -1.79994010062498 0.0240907553664751 no 3271 0.0359350484330134 4631 3396 An atypical antipsychotic.
SGTC_970 1315-0089 19.5 µM -1.80125534025992 0.0240100463056753 no 3272 0.0358313217166969 4608 6811083 YLR033W RSC58
SGTC_1205 4161-2785 76 µM -1.80367461747489 0.02386218179732 no 3273 0.0356411654637257 4612 3498106
SGTC_1097 itavastatin 7.23 µM -1.82053921796644 0.0228525521979318 no 3274 0.0343384647666831 4648 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2958 9077254 16.72 µM -1.82125770412562 0.0228103504947668 no 3275 0.0342838462829313 4635 16457351
SGTC_1448 4255-0083 152 µM -1.8217490688392 0.0227815270454481 no 3276 0.0342465344375709 4661 5399660
SGTC_1055 3448-0672 86 µM -1.82291262749634 0.0227133950765467 no 3277 0.0341583125462192 4598 748378
SGTC_2012 4023501 200 µM -1.82620820003795 0.0225213547937751 no 3278 0.0339094533245933 4615 3477460
SGTC_929 2805-0021 398 µM -1.83177114098351 0.0222002962538943 no 3279 0.033492762267145 4647 3098024
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.84664770176355 0.0213606332088794 no 3280 0.0323991079619348 4624 16623 A steroid.
SGTC_3000 9075062 71.4286 µM -1.85443940977609 0.0209316740356939 no 3281 0.0318381605025578 4633 17057871
SGTC_3038 9091290 49.47 µM -1.85641641454323 0.020824000483087 no 3282 0.03169711342325 4633 25236843
SGTC_95 0471-0001 561.058 µM -1.85746695408628 0.0207669760216766 no 3283 0.0316223742373477 4627 4015405
SGTC_496 calpeptin 138 µM -1.85913500599913 0.0206767039677596 no 3284 0.031504002239449 4623 73364 A calpain inhibitor.
SGTC_2213 7173844 200 µM -1.86079685792436 0.0205870981555852 no 3285 0.0313864346975736 4664 892728
SGTC_1950 st077106 7.18 µM -1.86939133386333 0.0201289231745645 no 3286 0.0307841946927321 4566 13831864
SGTC_1297 1068-0111 14.1 µM -1.87678517571695 0.0197417026597104 no 3287 0.0302737715229232 4653 767057
SGTC_286 k060-0067 22.9 µM -1.8837685347889 0.0193818041924152 no 3288 0.0297981457208772 4678 5985051
SGTC_2534 helenine 20.12 µM -1.88617856408349 0.019258900367526 no 3289 0.0296354480619086 4657 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1187 1391-0724 117 µM -1.89359681167966 0.0188847426866749 no 3290 0.0291392735207647 4683 6997986
SGTC_1244 0416-0015 52.5 µM -1.89834696065181 0.0186484192737244 no 3291 0.0288251958015293 4626 96201
SGTC_3132 9126706 49.47 µM -1.89918839070615 0.0186068210473981 no 3292 0.0287698552970386 4652 850858
SGTC_2005 4024620 188 µM -1.90075981724721 0.018529345098111 no 3293 0.028666739763123 4608 236743
SGTC_571 k831-0106 44.2 µM -1.90260871502065 0.0184385408828562 no 3294 0.0285458105622249 4565 4783639
SGTC_1028 k015-0029 4.8 µM -1.90882040466165 0.0181362390506725 no 3295 0.0281426318461321 4655 4588309
SGTC_2105 5350118 200 µM -1.91147391929814 0.0180083950595789 no 3296 0.0279718526499328 4632 2133313
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.91700968372675 0.0177441587615083 no 3297 0.0276183507092659 4679 165506
SGTC_711 k292-0785 179 µM -1.94676880074613 0.0163796885457797 no 3298 0.025781229483106 4627 4146315
SGTC_1575 cyproterone acetate 48 µM -1.95547555972666 0.01599787655068 no 3299 0.0252634826679631 4648 9880 An androgen receptor antagonist and liver toxin.
SGTC_336 4111-0029 111 µM -1.9602129473291 0.0157933540989676 no 3300 0.0249854529020414 4688 3131175
SGTC_2383 9036125 200 µM -1.961503513908 0.0157380279631586 no 3301 0.0249101577483055 4644 79580
SGTC_94 0334-0113 514.748 µM -1.96163662832193 0.0157323308646935 no 3302 0.0249024023286409 4676 6795178
SGTC_2900 5328528 85.29 µM -1.96350427471971 0.0156525847276692 no 3303 0.024793804132311 4654 795359
SGTC_275 trichlorophene 5.69 µM -1.96449591760751 0.0156103839706581 no 3304 0.0247363046212011 4695 62616
SGTC_2419 paclitaxel 166.5 µM -1.97338053810642 0.0152366230540018 no 3305 0.0242261116225423 4623 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2144 5628481 200 µM -1.99829659270288 0.0142291895251544 no 3306 0.0228422573479772 4685 2818399
SGTC_2870 9038528 12.99 µM -2.00031112432875 0.0141503026281716 no 3307 0.0227333392703874 4692 6463316
SGTC_8 0354-0001 70 µM -2.00577595964438 0.0139382005168973 no 3308 0.0224400783384987 4678 4993152
SGTC_1074 carmofur 3.8 µM -2.01453498302714 0.0136039611855677 no 3309 0.0219766979133804 4728 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1240 0356-0016 42.1 µM -2.01466392218163 0.0135990930565008 no 3310 0.0219699374149872 4666 4305613
SGTC_3285 9112818 20.8695 µM -2.02839743268689 0.0130891152510463 no 3311 0.0212598509597343 4678 17017947 YPR165W RHO1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -2.03263981303813 0.01293495871541 no 3312 0.0210444630434572 4670 688803
SGTC_1991 st073000 8.92 µM -2.04189110422947 0.0126042278071997 no 3313 0.020581167192912 4693 4301969 YIL048W NEO1
SGTC_1356 1502-0781 85.8 µM -2.05599094104569 0.0121142464902882 no 3314 0.0198916946985077 4711 567702
SGTC_2259 7964009 200 µM -2.05667854207521 0.012090779951369 no 3315 0.0198585787823831 4706 313134
SGTC_789 1309-1135 70.6 µM -2.0711794923171 0.0116049884567431 no 3316 0.0191710126665277 4681 3092424
SGTC_1540 guanosine 70.6 µM -2.08782606710415 0.011068293129361 no 3317 0.0184067636303936 4678 6802 Guanosine is a purine nucleoside
SGTC_2260 7964312 200 µM -2.09023971397577 0.0109922957783501 no 3318 0.0182981358497352 4710 231951
SGTC_210 3551-0445 56.827 µM -2.11703984467402 0.0101784902976537 no 3319 0.0171282331613595 4668 2865180 YOR207C RET1
SGTC_2640 pentamidine 10.38 µM -2.12743905806503 0.00987715954052374 no 3320 0.0166918098990809 4671 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2334 9017922 200 µM -2.15839561394693 0.00902578904694621 no 3321 0.0154485432260296 4702 3163164
SGTC_1873 rapamycin 2 nM -2.15946607406319 0.00899753573821861 no 3322 0.0154070132991401 4703 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_587 k089-0003 57 µM -2.16855929016725 0.00876064064620941 no 3323 0.0150580793514261 4677 9659696
SGTC_2761 levamisole 97.89 µM -2.17653158799764 0.00855746431679664 no 3324 0.0147577671767774 4714 26879 An alkaline phosphatase inhibitor.
SGTC_32 0928-0142 34.1 µM -2.2026498416385 0.00792050245685034 no 3325 0.0138097190377389 4735 2244242
SGTC_2975 9084847 53.72 µM -2.21198959038177 0.00770306492693313 no 3326 0.0134836921009128 4696 27211724
SGTC_1385 3091-4834 14.1 µM -2.22086262979797 0.00750137735604684 no 3327 0.0131801335138518 4710 4072814
SGTC_2934 9036370 36.88 µM -2.22453110137941 0.0074193602260684 no 3328 0.0130563661891003 4696 6462800
SGTC_215 1287-0124 461.5 µM -2.23128248791673 0.00727048079385477 no 3329 0.0128312114652722 4756 5560863
SGTC_867 0518-0118 155 µM -2.24230411771632 0.00703309111425643 no 3330 0.0124708619069212 4712 6848158
SGTC_1877 wortmannin 25 µM -2.2534027264872 0.0068009823547487 no 3331 0.0121168838916313 4731 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2962 9082311 13.18 µM -2.25358635427984 0.00679719968064521 no 3332 0.0121111012911398 4722 16459453
SGTC_3042 9091578 49.47 µM -2.27192760178917 0.00642861486797202 no 3333 0.0115454417335883 4732 25236497
SGTC_3027 9089541 49.47 µM -2.2731923741756 0.00640386241917217 no 3334 0.0115072948239773 4726 9943819
SGTC_3026 9090633 49.47 µM -2.37627180704006 0.0046493131484788 no 3335 0.00874428744752879 4750 25236842
SGTC_1759 st043059 70 µM -2.38002296309312 0.00459446535697858 no 3336 0.00865577961457239 4758 669426
SGTC_1497 4476-2978 41.3 µM -2.38256108585299 0.00455768232604402 no 3337 0.00859633964530359 4768 1528379
SGTC_3032 9089427 49.47 µM -2.39097893825327 0.00443756348782315 no 3338 0.0084017583972128 4727 17173707
SGTC_2222 6885208 172.143 µM -2.3920441418994 0.00442256686161292 no 3339 0.00837741357361609 4777 609514
SGTC_47 0149-0135 24.25 µM -2.40580508286395 0.00423286185297884 no 3340 0.00806843595959119 4736 5239155
SGTC_2705 st078069 42.8 µM -2.45722061719783 0.00358680696104828 no 3341 0.00700083355930718 4757 1530061
SGTC_2729 fluphenazine 10.66 µM -2.48939036456975 0.00322904674719987 no 3342 0.00639811892328293 4749 3372 An atypical antipsychotic.
SGTC_1876 myriocin 605 nM -2.57494914400067 0.00242849822120771 no 3343 0.00501274131696795 4735 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_966 1300-0360 30.2 µM -2.58488416174491 0.00234825932509644 no 3344 0.00487058593466154 4769 70588
SGTC_223 busulfan 5 mM -2.59355816224951 0.00228017569010096 no 3345 0.00474942355602016 4781 2478 A DNA alkylator.
SGTC_3101 9120531 49.47 µM -2.62214009824419 0.00206829550019223 no 3346 0.0043689751588035 4753 24824904
SGTC_599 1935-0052 86.5 µM -2.62337731982037 0.00205954092504284 no 3347 0.00435313966760939 4770 9557311
SGTC_1474 0330-0125 5.35 µM -2.69003387679793 0.00163475121499091 no 3348 0.00357223829755723 4798 X1474
SGTC_3159 9100096 49.47 µM -2.82127107833388 0.00102277379038696 no 3349 0.00239168818562891 4752 25236875
SGTC_129 0088-0017 176.636 µM -2.89975274115546 0.000765710520614753 yes 3350 0.0018672856444668 4744 182446
SGTC_1870 st057514 26.5 µM -3.15774066922672 0.000281869337696717 yes 3351 0.000794984660911536 4795 5393161
SGTC_1767 st044992 70.3 µM -3.15896743126104 0.000280483756600004 yes 3352 0.000791645914665477 4797 9600693
SGTC_1920 st075728 45.7 µM -3.18179709162098 0.000255828299734106 yes 3353 0.000731821608474649 4790 3400306
SGTC_260 nsc-65238 3.989 µM -4.16738330370386 2.76530462611556e-06 yes 3354 1.54058078336898e-05 4809 3246252
SGTC_2635 hydroquinidine 100 µM -4.52636742132192 4.04983455279004e-07 yes 3355 3.00031075703053e-06 4805 442912 An experimental heart treatment.
SGTC_2634 4'-methoxyflavone 100 µM -6.82218291695463 5.72142170587978e-14 yes 3356 4.48336947678421e-12 4810 77793 From seeds of Psoralea corylifolia (Fabaceae)