SGTCid condition conc unit YOR365C|YOR365C.score YOR365C|YOR365C.strain.pval YOR365C|YOR365C.strain.significant YOR365C|YOR365C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2919 7978188 46.38 µM 6.98574220805127 4.79446083697645e-14 yes 1 1.41676977451552e-12 1 2980291 SGTC_130 0136-0219 337.655 µM 6.22976162530383 1.53469278898279e-11 yes 2 2.33572710210722e-10 3 234244 SGTC_2455 5377712 9.75 µM 5.63862683835828 8.98807834852919e-10 yes 3 8.57057692658779e-09 8 2243908 SGTC_140 0062-0056 502.533 µM 5.32805525058938 6.53583662322511e-09 yes 4 4.96349648489207e-08 8 3758964 SGTC_1068 loratadine 26.9 µM 4.96521140117136 5.80290008763502e-08 yes 5 3.4313137356396e-07 11 3957 A H1 histamine antagonist. SGTC_2638 epoxomicin 18 µM 4.68111399789714 2.9003093999376e-07 yes 6 1.42660107714352e-06 19 9915668 A protesome inhibitor. SGTC_830 4076-0286 57.8 µM 4.50237287028132 7.62908374461884e-07 yes 7 3.35994758947139e-06 41 6866659 SGTC_3026 9090633 49.47 µM 4.43253956483469 1.10272294366827e-06 yes 8 4.65648030132502e-06 11 25236842 SGTC_2474 5321570 43.32 µM 4.39967568652514 1.30906868239353e-06 yes 9 5.42063886138975e-06 7 2841384 SGTC_2927 9011802 47.9 µM 4.38984620457843 1.3776687109887e-06 yes 10 5.67154278675229e-06 18 43912568 SGTC_3136 9095672 49.47 µM 4.1377693296452 4.92529732322857e-06 yes 11 1.75349337603697e-05 22 17217380 SGTC_2188 6126565 140.678 µM 4.0728373720263 6.76244046542013e-06 yes 12 2.3221927374688e-05 12 874518 SGTC_2991 9074669 71.4286 µM 4.00365572776593 9.43199269602999e-06 yes 13 3.11855557731322e-05 60 17333109 SGTC_2837 9008476 45.46 µM 3.93077528070483 1.3316737286284e-05 yes 14 4.23361925038847e-05 34 2992805 SGTC_2105 5350118 200 µM 3.90084449565377 1.5317714842666e-05 yes 15 4.79288563198718e-05 28 2133313 SGTC_2541 muurolladie-3-one 83.07 µM 3.76843286176023 2.81265220865817e-05 yes 16 8.21378276951721e-05 36 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_914 3820-6779 408 µM 3.68083869124827 4.16102965833684e-05 yes 17 0.000116234022204488 33 2893481 SGTC_572 0960-0087 17.7 µM 3.64511505958891 4.87010186244746e-05 yes 18 0.000133636098469403 36 6796365 SGTC_198 3454-2873 16.191 µM 3.54829471713345 7.40897065774461e-05 yes 19 0.000193867054152177 25 710957 SGTC_160 3453-0671 289.699 µM 3.4689365809132 0.000103719061720752 yes 20 0.000261261391697323 54 5322268 SGTC_2116 5511452 16.8835 µM 3.4603440459827 0.000107523160540971 yes 21 0.000269742813834422 27 870744 SGTC_912 3474-0017 2.18 µM 3.40446148654426 0.000135645182912487 yes 22 0.000331473240595112 40 3360550 SGTC_589 1227-0070 34.1 µM 3.39028400861981 0.000143804655060868 yes 23 0.00034910124655243 42 2841384 SGTC_165 k038-0023 64.381 µM 3.38367552121424 0.000147763113115917 yes 24 0.000357612375797501 114 46368543 SGTC_869 0564-0080 44.1 µM 3.26760940228061 0.000236261023149283 yes 25 0.000542299692216176 41 6843321 SGTC_497 capsazepine 133 µM 3.25588147782049 0.00024753747056022 yes 26 0.000565204641935637 34 2733484 A calcium channel blocker. SGTC_27 0485-0001 32.618 µM 3.18778519597918 0.000323561752670662 yes 27 0.000716834985744418 12 2054479 SGTC_1884 5633444 25 µM 3.16789922383329 0.000349559364068425 yes 28 0.000767723674241251 92 5724239 SGTC_863 0466-0191 129 µM 3.14775365895391 0.000377865228146595 yes 29 0.00082265142480556 115 765160 YPR165W RHO1 SGTC_191 3914-0123 66.505 µM 3.02487103833072 0.000601949535995384 yes 30 0.00124369581555919 10 3144412 SGTC_2764 methyldopa 94.69 µM 3.01928412835692 0.000614595367041212 yes 31 0.00126686393612411 68 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1219 1469-0211 33.1 µM 3.01145300742669 0.00063273420111329 yes 32 0.00130000321600112 46 6822282 SGTC_7 0192-1582 4.227 µM 3.0109954768438 0.00063380908729896 yes 33 0.00130196365719982 130 252616 SGTC_46 0329-0187a 2.197 µM 2.9974547158415 0.000666394200005837 yes 34 0.00136122151016953 135 46494817 SGTC_1594 piperine 70.1 µM 2.98407131622525 0.000700113221375046 yes 35 0.00142220233282064 60 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1950 st077106 7.18 µM 2.92649306655021 0.000863890785289259 yes 36 0.00171403573497382 81 13831864 SGTC_3328 9140624 29.0385 µM 2.91612896407098 0.000896870931597231 yes 37 0.00177201987883223 61 4904392 SGTC_618 k072-0232 33.2 µM 2.90181330056161 0.000944330427439109 yes 38 0.00185504790601782 49 5872756 YGL099W LSG1 SGTC_2937 9044753 11.33 µM 2.88942942269534 0.000987234939102488 yes 39 0.00192970815829087 93 6465530 YGL099W LSG1 SGTC_120 rhodamine 6G 52.259 µM 2.86300836362488 0.00108481446149669 no 40 0.00209819743143165 108 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1052 3253-3998 198 µM 2.85191953445543 0.00112834193711342 no 41 0.00217280497076209 87 5450317 SGTC_550 4123-0385 25.7 µM 2.842117827222 0.00116814324829172 no 42 0.00224074626978893 88 5731123 SGTC_820 1582-0060 59.9 µM 2.8291077361466 0.00122295878119077 no 43 0.00233389912694222 93 3848840 SGTC_1145 3546-0597 10.2 µM 2.78251594503004 0.00143913307365366 no 44 0.00269696073772078 88 875334 SGTC_1157 4092-0394 27.6 µM 2.75088332894954 0.00160520491765007 no 45 0.00297174037741236 103 3659885 SGTC_313 3474-0040 5.03 µM 2.74563093758238 0.00163441286492825 no 46 0.0030197330869316 172 1043375 YIL048W NEO1 SGTC_333 3486-0131 40.1 µM 2.73751982387937 0.00168046997644438 no 47 0.0030952194491879 55 6744690 SGTC_1130 3454-2858 15.9 µM 2.68701067599357 0.00199486486843284 no 48 0.00360473242052986 165 715628 YIL048W NEO1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.67949853713913 0.00204593685721803 no 49 0.00368662627146909 62 616764 SGTC_936 3005-4620 401 µM 2.65400821474821 0.00222820289437997 no 50 0.00397709452154774 116 777207 SGTC_1935 st074532 41.6 µM 2.6485524314118 0.0022690762339677 no 51 0.00404186544278996 121 2829742 SGTC_1346 1488-2224 62.4 µM 2.64699644441417 0.00228085712433702 no 52 0.00406051034342937 75 3722427 SGTC_2893 9048488 25.97 µM 2.6456905524202 0.00229078719325578 no 53 0.00407621781576528 91 6467338 SGTC_1485 3909-9022 254 µM 2.64041648177236 0.00233129112083162 no 54 0.00414020995295456 77 714516 SGTC_934 2950-0684 338 µM 2.58266790253464 0.00281914941804131 no 55 0.00490198221261762 105 1121253 SGTC_2473 5854593 8.94 µM 2.58120319774799 0.00283264088316745 no 56 0.00492283057434848 68 2872951 SGTC_1545 lovastatin 49.4 µM 2.56669508969837 0.00296945493173625 no 57 0.00513364255532792 129 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.55748473321823 0.00305937201875449 no 58 0.00527160929115253 122 3256 An antibiotic and ribosome inhibitor. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.54364077217427 0.00319914243839788 no 59 0.00548519210470068 167 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2644 guaiazulene 100 µM 2.54286938957897 0.00320709680574567 no 60 0.00549731593403241 50 3515 A coloring agent. SGTC_2629 bisabolol 100 µM 2.54221768901769 0.00321383089517217 no 61 0.00550757726888093 119 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3101 9120531 49.47 µM 2.51762301812147 0.00347745604371425 no 62 0.00590748511811302 137 24824904 SGTC_681 1642-0006 26.6 µM 2.51067906546951 0.00355532314880089 no 63 0.00602495956825913 47 4446530 SGTC_1480 1070-0044 41.2 µM 2.47932645730035 0.0039267419536648 no 64 0.00658153839058427 111 3124987 SGTC_3063 1327-0034 4 µM 2.47441578259516 0.00398796443334103 no 65 0.0066727140509633 137 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3103 9120822 49.47 µM 2.46867960913983 0.00406055994555605 no 66 0.00678062885730284 106 17141819 SGTC_2642 cholecalciferol 100 µM 2.46354590142478 0.00412653149384911 no 67 0.00687851396444707 89 9821465 A vitamin D precursor, similar to steriods. SGTC_2602 kawain 100 µM 2.4546187976158 0.00424353768728943 no 68 0.00705170279834982 145 5369129 SGTC_2532 xanthone 78.9 µM 2.44238897440195 0.00440864660213495 no 69 0.00729520834714585 129 7020 An insecticide. SGTC_1898 st060199 18.6 µM 2.43724025846759 0.00447985699824593 no 70 0.00739992120169964 98 688866 SGTC_1000 4048-0884 8.67 µM 2.42305511800467 0.00468139020619799 no 71 0.00769529567467265 137 13040088 SGTC_3032 9089427 49.47 µM 2.42289854227254 0.00468365915308384 no 72 0.00769861311306439 109 17173707 SGTC_2841 9004761 38.96 µM 2.41965200362434 0.00473092649752071 no 73 0.00776768316983524 138 2991039 SGTC_2156 5649887 115 µM 2.39958168233733 0.00503269662137547 no 74 0.00820690865604003 131 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2567 aureobasidin a 60 nM 2.37081713038404 0.00549507523996613 no 75 0.00887440511306242 239 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1767 st044992 70.3 µM 2.35811947607214 0.00571092707924722 no 76 0.00918389013094708 151 9600693 SGTC_3290 9121031 71.43 µM 2.35180960403833 0.00582096436007652 no 77 0.00934116746265592 110 17014854 SGTC_3166 9102297 49.47 µM 2.33260768456433 0.0061674849819167 no 78 0.00983437262642937 170 25237072 SGTC_1400 3771-8998 51.5 µM 2.32087439683953 0.00638810954324906 no 79 0.0101468118717434 74 670767 SGTC_892 0929-0076 29 µM 2.31578211212983 0.00648601519600094 no 80 0.0102850841976792 200 5751038 SGTC_2715 st079500 56.4 µM 2.30877141141244 0.00662297572291418 no 81 0.0104781346163586 117 28246688 SGTC_2696 st077691 74.316 µM 2.30508564702633 0.00669600100227662 no 82 0.0105808885882578 159 757133 SGTC_1163 k060-0048 49.9 µM 2.3050180659286 0.0066973465900403 no 83 0.0105827808215387 163 6809982 SGTC_2049 5262831 67.185 µM 2.30441839877121 0.00670929686225801 no 84 0.0105995840868241 164 763417 SGTC_1523 st012844 44.7 µM 2.30028407820265 0.0067922003718853 no 85 0.0107160655561482 161 4274103 SGTC_2770 toltrazuril 17.5 µM 2.29739347991637 0.00685070044297616 no 86 0.0107981666936624 158 68591 Kills coccidiodes. SGTC_1420 4'-methoxyflavone 42 µM 2.28724775339325 0.0070595674837785 no 87 0.0110906830762563 124 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2117 5521686 200 µM 2.27564834386726 0.00730522884153726 no 88 0.0114335326922667 154 803312 SGTC_1656 st012921 11 µM 2.27471822250931 0.00732525023376598 no 89 0.0114614193177728 133 6732821 SGTC_1375 2910-0797 186 µM 2.27034701883902 0.00741999210984875 no 90 0.0115932681710815 149 742508 SGTC_1077 5-fluorocytosine 377 nM 2.26937400647597 0.00744122761313511 no 91 0.0116227957600437 140 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2628 lathosterol 100 µM 2.26458962345479 0.00754642521971879 no 92 0.011768937137995 168 6710616 SGTC_1146 3579-1023 7 µM 2.25759081961934 0.00770267212749345 no 93 0.011985590766899 172 X1146 SGTC_256 clotrimazole 625 nM 2.25510030688945 0.00775895535510806 no 94 0.0120635166967004 190 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3185 9108267 49.47 µM 2.25066657766379 0.00786004953107181 no 95 0.0122033315712997 173 4910486 SGTC_792 4534-1957 155 µM 2.24272419193376 0.00804404471134156 no 96 0.0124573028052351 177 1717904 SGTC_1581 himbacine 57.9 µM 2.23975228894595 0.00811385976891196 no 97 0.0125535044336954 194 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1335 1486-0900 202 µM 2.23175425162142 0.00830439873350585 no 98 0.0128156047291934 187 X1335 SGTC_2025 5147754 141 µM 2.22643830891016 0.00843320505928537 no 99 0.0129924184351837 119 315777 YLR208W SEC13 SGTC_1575 cyproterone acetate 48 µM 2.22546604626117 0.00845695193362412 no 100 0.0130249840202222 166 9880 An androgen receptor antagonist and liver toxin. SGTC_795 0685-0265 78 µM 2.22407977760401 0.00849091212048879 no 101 0.0130715386066376 183 302754 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.22218950104246 0.00853741208872477 no 102 0.013135250844907 141 756377 SGTC_811 0416-0114 265 µM 2.19991787450781 0.00910233842107796 no 103 0.0139063611450968 183 6612453 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.19211791158505 0.00930778639427972 no 104 0.0141854968671638 143 229346 A bile salt which induces apoptosis. SGTC_3065 9113888 49.47 µM 2.18818671524626 0.00941286195478873 no 105 0.0143280021973902 158 16648368 SGTC_3013 9080133 71.4286 µM 2.16893896208612 0.0099424396635794 no 106 0.015043659113789 199 17050193 SGTC_331 k048-0133 24.5 µM 2.16893684859618 0.00994249921340913 no 107 0.015043739352936 133 6813582 SGTC_3050 9093513 49.47 µM 2.16343587338307 0.0100985541006422 no 108 0.0152538354674258 165 25236664 SGTC_628 1636-0253 16 µM 2.16331274508187 0.0101020713941558 no 109 0.0152585667398565 212 4456143 SGTC_1131 3454-3128 32.3 µM 2.15429894121982 0.0103624811376732 no 110 0.0156083679311327 231 710982 SGTC_2626 ethyl orsellinate 100 µM 2.15316769173359 0.010395572846957 no 111 0.0156527509128991 174 75653 A natural product. SGTC_1072 oxiconazole 14.9 nM 2.14030136550671 0.0107784731506959 no 112 0.0161652098552949 217 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_221 trifluoperazine 10.304 µM 2.13069158727234 0.0110724138537484 no 113 0.0165572793047558 416 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2068 5226020 147 µM 2.12801113177738 0.0111556362744621 no 114 0.0166680803201543 232 1810509 SGTC_1492 4158-0558 28.5 µM 2.12563453935275 0.0112298787633573 no 115 0.0167668506836779 176 3967268 SGTC_587 k089-0003 57 µM 2.12520787367419 0.0112432527736028 no 116 0.0167846356692344 85 9659696 SGTC_2523 spermine 47.74 µM 2.12375663156902 0.0112888462403452 no 117 0.0168452495818134 176 1103 A DNA binding polyamine. SGTC_340 k038-0059 454 µM 2.12148690165734 0.0113604762223052 no 118 0.0169404245301056 203 23733424 SGTC_2390 9097792 176.6 µM 2.11209990353675 0.0116609290052793 no 119 0.0173389406400819 163 4497149 SGTC_2481 5478948 45.16 µM 2.11203323640375 0.0116630872781005 no 120 0.0173417993228332 219 77792 SGTC_1478 0453-0656 35.7 µM 2.10856028699026 0.011776000694051 no 121 0.0174912769122569 168 5258496 SGTC_1837 st055472 66.5 µM 2.10781574099995 0.0118003306730147 no 122 0.0175234653663209 193 676091 SGTC_87 0100-0052 35.5 µM 2.10600188131522 0.0118597859077446 no 123 0.0176020944651755 415 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2398 5228213 48.84 µM 2.09848603821145 0.0121089202811874 no 124 0.0179311159878566 267 80771 YMR134W ERG29 SGTC_2251 lansoprazole 556 µM 2.09754074318127 0.0121405737714526 no 125 0.0179728672039851 152 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1930 st074634 34.3 µM 2.09663567824372 0.0121709473295119 no 126 0.0180129192114541 205 684253 YOR116C RPO31 SGTC_558 k064-0027 21.3 µM 2.09308930116177 0.012290597600956 no 127 0.0181705917967729 202 5088526 SGTC_2112 5488546 200 µM 2.09012110257258 0.0123915229836718 no 128 0.0183034612454927 203 600757 SGTC_1162 k048-0130 20.1 µM 2.0872784526596 0.0124888515565199 no 129 0.0184314856854097 182 6797406 SGTC_2617 dihydrotanshinone i 20.83 µM 2.07919256897014 0.0127693291121391 no 130 0.0187998271992168 247 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.07849489158513 0.0127937830931743 no 131 0.0188319004605742 148 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1603 st002045 67.8 µM 2.06165011316432 0.0133966219673735 no 132 0.0196205296423098 168 5887985 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.0542010833593 0.0136709333590806 no 133 0.0199781168026651 182 689007 SGTC_2043 5101342 149 µM 2.05327721001118 0.013705290604077 no 134 0.0200228499300988 210 678451 SGTC_527 4476-4215 268 µM 2.04731432252149 0.0139288370082677 no 135 0.0203136162643039 233 4418754 SGTC_3155 9099265 49.47 µM 2.03565662268618 0.0143749724119448 no 136 0.0208924238537545 200 25236499 SGTC_159 3970-0959 50 µM 2.03391137475133 0.0144428101616159 no 137 0.0209802659473941 412 6615653 SGTC_3021 9087658 49.47 µM 2.0308205080135 0.0145636284712515 no 138 0.0211366029392117 140 25237042 SGTC_725 1497-0963 19 µM 2.02958446329375 0.014612186899065 no 139 0.0211993977486332 183 3549977 SGTC_1270 0831-1170 17.3 µM 2.02915442678682 0.0146291136618113 no 140 0.0212212818722192 203 6764716 SGTC_2208 7283366 200 µM 2.02445429684624 0.0148152191202271 no 141 0.0214617149531968 187 898663 SGTC_986 1493-0483 84 µM 2.02304893586452 0.0148712594513263 no 142 0.0215340512399296 187 40079 SGTC_2670 beta-carotene 100 µM 2.02023774059341 0.014983906132813 no 143 0.0216793666504658 130 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1923 st058458 19.1 µM 2.01876620974424 0.0150431633711404 no 144 0.021755762331421 264 3534982 SGTC_845 0330-0138 4.51 µM 2.01446139062194 0.0152176723638197 no 145 0.0219805572751506 199 9039800 SGTC_23 0213-0011 39.996 µM 2.01022334880222 0.0153911702468757 no 146 0.0222037776360657 218 627608 SGTC_2196 6573537 42.6665 µM 2.00973382692925 0.0154113193952366 no 147 0.0222296838712539 165 2903087 SGTC_1136 pergolide 1.05886 µM 2.00898067654505 0.0154423639483853 no 148 0.0222695915269394 315 47811 A dopamine receptor agonist. SGTC_783 0848-0141 92.7 µM 2.0034481860006 0.0156720608872795 no 149 0.0225646018990157 205 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2704 st078022 71.1 µM 1.99955570695791 0.0158354193758417 no 150 0.022774130418922 201 54697681 SGTC_197 4544-0043 41.561 µM 1.99825913848771 0.0158901566295783 no 151 0.0228442865112173 278 896523 SGTC_751 0833-0568 350 µM 1.99199313077521 0.0161569809554074 no 152 0.023185905790532 210 6954252 SGTC_95 0471-0001 561.058 µM 1.98691579870875 0.0163759949859677 no 153 0.0234658642769038 232 4015405 SGTC_1385 3091-4834 14.1 µM 1.97671976396666 0.0168234943764836 no 154 0.0240366577561624 204 4072814 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.97062905895118 0.0170957710147399 no 155 0.0243831601478567 217 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1625 st003711 30.1 µM 1.96013266827228 0.0175738375411225 no 156 0.02499014289708 233 24207034 YER133W GLC7 SGTC_594 1487-1584 10.8 µM 1.94542855873715 0.0182627064541868 no 157 0.0258617101602486 232 5013332 SGTC_473 2-arachidonoylglycerol 10 µM 1.94349094995557 0.0183551743438387 no 158 0.0259784338993695 238 5282280 An endocannabinoid. SGTC_2777 climbazole 1.536 µM 1.93665040298063 0.0186848195894002 no 159 0.0263940461414543 272 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_299 1273-0059 1.44 µM 1.91593743466577 0.0197138645423892 no 160 0.0276865299268522 214 2848077 SGTC_72 0744-0168 198.391 µM 1.91546112185335 0.0197380832673332 no 161 0.0277168613558933 244 677577 SGTC_266 formosanin C 406 nM 1.91463322422103 0.0197802388683687 no 162 0.0277696474728535 295 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1056 3448-1962 115 µM 1.91411021945342 0.0198069090413148 no 163 0.027803037008016 223 715507 SGTC_1292 0kpi-0043 232 µM 1.91307550692584 0.0198597632350726 no 164 0.027869193410848 231 3333905 SGTC_3218 9131285 49.47 µM 1.91232830725208 0.019898005355313 no 165 0.027917048606125 296 17156417 SGTC_2997 9067075 71.4286 µM 1.91164711478713 0.0199329236203963 no 166 0.027960735926216 283 27209819 SGTC_2266 7929956 200 µM 1.90509732598725 0.0202713303462269 no 167 0.0283837104742745 262 2967153 SGTC_3201 9113999 49.47 µM 1.90390504289486 0.0203334529276974 no 168 0.0284612761149767 264 16649224 SGTC_2517 totarol 10 µM 1.90138135348656 0.0204654793843978 no 169 0.0286260400500614 238 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1632 st005650 90 µM 1.89380214949363 0.0208663588864387 no 170 0.0291256381241225 259 2759605 SGTC_865 0488-0499 301 µM 1.89164682708927 0.0209815649978198 no 171 0.0292690261712455 241 9634651 SGTC_335 4077-0256 27.6 µM 1.88369072242095 0.021411505959244 no 172 0.0298034110476048 266 3121989 SGTC_867 0518-0118 155 µM 1.8836733443368 0.0214124531472423 no 173 0.0298045870752373 249 6848158 SGTC_2199 6590217 200 µM 1.88158223159222 0.0215266875890149 no 174 0.0299463803029183 161 703109 SGTC_883 0850-0245 24.6 µM 1.86789537320381 0.0222871691971167 no 175 0.0308883279677061 289 6823229 YPR165W RHO1 SGTC_178 4092-0806 87.505 µM 1.86314575464346 0.0225563150249458 no 176 0.0312208811857455 401 2169044 SGTC_2555 cholic acid 100 µM 1.85962372063224 0.022757662525499 no 177 0.0314693904475737 240 6708657 Influences liver metabolism. SGTC_1780 st038448 24.544 µM 1.85278933244935 0.0231526932806639 no 178 0.0319562799117647 267 728868 YDL195W SEC31 SGTC_451 chloral hydrate 100 µM 1.85166290214763 0.0232183524660679 no 179 0.0320371221586948 352 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_545 4218-0007 221 µM 1.84941968175235 0.023349575879643 no 180 0.0321986178119345 258 2840508 SGTC_2366 9070441 60.58 µM 1.84745344791322 0.0234651089509075 no 181 0.0323407245176629 291 6837235 SGTC_123 0083-0120 66.675 µM 1.84737883731409 0.0234695024168736 no 182 0.0323461270664619 290 16001701 SGTC_3070 9117005 49.47 µM 1.84500242499412 0.0236098006182576 no 183 0.0325185929276957 185 8779016 SGTC_318 1488-0629 67.2 µM 1.83977354732355 0.0239209870646816 no 184 0.0329007452918937 241 3662576 SGTC_2017 5132927 60.65 µM 1.83675170091744 0.0241023929788497 no 185 0.0331232795259545 297 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2783 7738165 71.43 µM 1.83147964982834 0.0244216489490164 no 186 0.0335144912143343 226 17201110 SGTC_836 0330-0104 1.35 µM 1.83055601142222 0.0244779449419292 no 187 0.0335834196679192 271 46494820 SGTC_1456 k015-0012 13 µM 1.82758068308239 0.0246600330683915 no 188 0.0338062535344556 323 2989616 SGTC_833 3852-0053 558 µM 1.82620023971837 0.0247449004753479 no 189 0.0339100526321796 298 3123681 SGTC_3308 9128332 17.569 µM 1.82267718503627 0.0249626032931552 no 190 0.0341761488762404 381 17332805 YDL196W YDL196W SGTC_2823 7987624 58.44 µM 1.82175554193301 0.0250198193681621 no 191 0.034246043125167 320 2239440 SGTC_2150 5556613 200 µM 1.81858736754263 0.0252173404517447 no 192 0.0344872032595164 286 743190 SGTC_2926 9010726 65.15 µM 1.81513230002336 0.0254342358452745 no 193 0.0347517902442403 297 2994293 SGTC_1140 3229-1848 2.98 µM 1.80252464235064 0.0262389912462634 no 194 0.0357314506180693 230 2849525 SGTC_1020 4335-0961 93.3 µM 1.79134638378807 0.0269702075142206 no 195 0.0366188635604904 269 669075 SGTC_2072 5231554 129 µM 1.78741284150121 0.0272315294893887 no 196 0.0369353938161193 246 789545 SGTC_1666 st014829 29 µM 1.78581126439265 0.0273385325078903 no 197 0.0370649111212804 320 3858230 SGTC_1956 st077085 54 µM 1.77748353609871 0.0279005840163735 no 198 0.0377443586460292 329 24208685 SGTC_954 1189-0853 2.85 µM 1.76289459438561 0.0289084082336121 no 199 0.0389591344653223 321 2828194 SGTC_117 lucigenin 22.078 µM 1.75943606548308 0.0291517145052239 no 200 0.0392517353346271 391 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1352 1496-0991 99 µM 1.75586862177944 0.0294044628521147 no 201 0.0395554219390269 304 3000039 SGTC_590 k048-0076 22.4 µM 1.75435870263549 0.0295119851637585 no 202 0.0396845314623436 291 6832814 SGTC_3327 9140648 26.9345 µM 1.75363772381985 0.0295634415421827 no 203 0.0397463013753101 279 8029710 SGTC_89 0302-0250 142.109 µM 1.74641288301826 0.0300832033567053 no 204 0.0403696164630923 332 4203518 YLR208W SEC13 SGTC_3236 9132701 49.47 µM 1.74387373832299 0.0302676616577559 no 205 0.0405905544363351 297 24282524 SGTC_2789 5281112 71.43 µM 1.7428727186024 0.0303406387344172 no 206 0.0406779252183691 341 765948 SGTC_876 0720-0963 56.8 µM 1.74222175142952 0.0303881742150154 no 207 0.0407348246461706 316 765861 SGTC_1255 0566-0045 221 µM 1.73906661306471 0.030619446588825 no 208 0.0410115232535704 327 2788469 SGTC_1928 4'-methoxychalcone 40.3 µM 1.72225805640468 0.0318762122509304 no 209 0.0425113910626597 269 641818 SGTC_645 0845-0943 5.41 µM 1.71897466091228 0.0321266178913774 no 210 0.0428094929695928 298 1885106 SGTC_2612 dictamnine 15.46 µM 1.71853176170751 0.032160519227265 no 211 0.0428498331255061 332 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2653 dihydrofissinolide 100 µM 1.71652738102751 0.0323143122501248 no 212 0.0430327804529414 245 6857746 SGTC_139 0099-0334 718.624 µM 1.7162308579324 0.0323371154581039 no 213 0.0430598987302746 392 97690 SGTC_1925 st057770 10.1 µM 1.71154089549589 0.0326995520710547 no 214 0.0434906542524952 296 5989122 SGTC_1050 3232-1156 69.3 µM 1.7096513328638 0.0328465195488873 no 215 0.0436651835968685 324 700529 SGTC_1302 1159-0335 255 µM 1.7023261064802 0.0334214209875287 no 216 0.044347126763658 303 649284 SGTC_1421 4029-0249 71.4 µM 1.69865984390412 0.0337122543272685 no 217 0.0446916468509952 342 2894095 SGTC_169 k015-0017 16.025 µM 1.69587818109765 0.0339343018353735 no 218 0.0449544762588657 292 1840002 SGTC_752 1896-0090 130 µM 1.69476823286722 0.0340232390767041 no 219 0.0450596979879179 319 772567 SGTC_3197 9113331 49.47 µM 1.68158334306086 0.0350944453163174 no 220 0.0463248314030969 364 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1641 st009299 47.1 µM 1.67748124974357 0.0354333099724701 no 221 0.0467242064983737 248 4046054 SGTC_2705 st078069 42.8 µM 1.67470021706315 0.0356645673432606 no 222 0.0469965324177619 305 1530061 SGTC_548 1436-0017 110 µM 1.67416549356817 0.0357091738782795 no 223 0.047049039527094 407 9677137 SGTC_3129 9127257 49.47 µM 1.66781387235904 0.0362425303296247 no 224 0.0476763405883956 310 837894 SGTC_3123 9126162 49.47 µM 1.66525959940416 0.0364588476609255 no 225 0.0479304875041542 314 25239884 SGTC_2213 7173844 200 µM 1.65146317110789 0.0376455805611303 no 226 0.0493220174808013 332 892728 SGTC_765 1319-0117 244 µM 1.64599405763348 0.0381246650740487 no 227 0.0498824912251694 320 3487746 YGL099W LSG1 SGTC_2225 6654152 15.4 µM 1.64515390960101 0.0381986992542284 no 228 0.049969037804181 264 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2687 chenodiol 100 µM 1.64318022401881 0.0383730825038225 no 229 0.0501728251442016 329 5702181 A cholesterol synthesis inhibitor. SGTC_1377 2944-0135 198 µM 1.63543636725546 0.0390635627830768 no 230 0.0509788019547425 387 1894137 SGTC_1327 1436-0082 2.18 µM 1.62878854758411 0.0396643532228806 no 231 0.0516788949695898 332 15992205 SGTC_78 0336-0123 156.75 µM 1.62777424587546 0.039756676998048 no 232 0.0517863816640091 318 6765896 SGTC_6 0844-0013 19.835 µM 1.62646670759984 0.0398759494522337 no 233 0.0519252050513607 620 1584900 SGTC_2158 5657123 3.6195 µM 1.62172704256619 0.0403107375123616 no 234 0.0524309029304465 310 2858827 SGTC_1209 2323-2347 50.3 µM 1.61583276300699 0.0408568057437929 no 235 0.0530652379386885 329 5412760 SGTC_1864 st057645 30.4 µM 1.60699398174617 0.0416868957461334 no 236 0.0540278441557923 307 688666 SGTC_771 0250-0039 27.3 µM 1.60689951537938 0.0416958407441768 no 237 0.0540382063748141 364 3005115 SGTC_2589 lobaric acid 100 µM 1.60379897874944 0.0419902937395654 no 238 0.054379184892711 375 73157 A novel microtubule depolymerizer. SGTC_394 menadione 8.33 µM 1.59989566289109 0.042363376438755 no 239 0.0548108658248068 384 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_289 k017-0060 526 µM 1.59910182296314 0.0424395795864189 no 240 0.0548989898528915 306 5512909 SGTC_3019 9081971 49.47 µM 1.59859549841912 0.0424882411249783 no 241 0.0549552553112481 353 16451803 SGTC_2131 toluylene red 5.2905 µM 1.59822608580036 0.0425237728770096 no 242 0.0549963351382094 394 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1414 3917-0015 5.4 µM 1.5965214144659 0.0426880471658407 no 243 0.0551862142870919 323 6618702 SGTC_3302 9125395 16.351 µM 1.59635084374438 0.0427045127747275 no 244 0.0552052422058929 351 17599668 SGTC_1843 st055809 45.5 µM 1.59557424449132 0.0427795447138672 no 245 0.0552919408062425 340 16413835 SGTC_1873 rapamycin 2 nM 1.59349531052517 0.0429809275977964 no 246 0.0555245597525613 435 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_67 0335-0847 266 µM 1.59138178764294 0.0431864455418962 no 247 0.0557618402400788 546 4552207 YOR254C SEC63 SGTC_1790 st045711 43.5 µM 1.58785334418607 0.0435313176311858 no 248 0.0561597528314713 369 585119 SGTC_469 w7 172 µM 1.58647253049235 0.0436668828633765 no 249 0.0563160793254312 268 45115570 A P450 inhibitor. SGTC_2856 9022925 19.48 µM 1.57877700984137 0.0444286638580389 no 250 0.0571936068334783 394 4944862 SGTC_2263 7948595 193.29 µM 1.57788204026746 0.0445179479358781 no 251 0.0572963558409614 300 2971371 SGTC_2151 5563267 85.4165 µM 1.57750798594222 0.0445553072020708 no 252 0.0573393430127125 395 5310824 SGTC_1298 1079-1278 263 µM 1.57632048926757 0.0446740776933502 no 253 0.0574759810045749 391 2840950 SGTC_1175 0741-0056 27.6 µM 1.57471338325924 0.0448352223934936 no 254 0.0576613086191032 436 765927 SGTC_3217 9129673 49.47 µM 1.57284124021716 0.0450235321714512 no 255 0.0578777918814926 394 17248312 SGTC_1714 st033236 13.627 µM 1.57070235884351 0.0452394503780841 no 256 0.0581259005180669 416 2916566 SGTC_405 ebelactone b 50 µM 1.56818722451662 0.0454944159236109 no 257 0.0584187225036922 401 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1457 k015-0032 57.3 µM 1.56763388127117 0.0455506645179041 no 258 0.0584833001449581 394 4302660 SGTC_306 1672-3436 11.6 µM 1.56630650891559 0.0456858228920992 no 259 0.0586384389716276 379 6797378 SGTC_1295 1013-0063 9.78 µM 1.56492517963945 0.0458268174862676 no 260 0.0588002269422011 399 6826038 SGTC_1449 4112-4002 201 µM 1.56303820945038 0.046019988591354 no 261 0.059021803919868 378 2059539 SGTC_253 dyclonine 31.25 µM 1.56288690347385 0.0460355062281191 no 262 0.0590395993130347 434 3180 An oral anasthetic. SGTC_79 0052-0007 94.094 µM 1.56177127630908 0.0461500525023463 no 263 0.0591709403734219 389 2801472 SGTC_2453 5731132 22.18 µM 1.55956558043824 0.0463771944874767 no 264 0.0594312878304218 410 1362040 SGTC_2019 4016004 108 µM 1.55808814267688 0.0465298419417237 no 265 0.0596061775547833 340 45595336 SGTC_1060 3448-7350 82 µM 1.55806531241473 0.0465322039024079 no 266 0.0596088832174633 417 570178 SGTC_1915 st067105 30.6 µM 1.54929740160805 0.0474464483017643 no 267 0.0606551220550787 412 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3011 9081274 71.4286 µM 1.54324139999737 0.0480862793885291 no 268 0.0613861079204123 419 6625322 SGTC_1253 0550-0034 176 µM 1.54252138487705 0.0481628078295852 no 269 0.0614734726992473 387 5969915 SGTC_3121 9125696 49.47 µM 1.53506143263986 0.0489614538841599 no 270 0.0623843693359121 330 1235365 SGTC_727 3032-0951 202 µM 1.5345720080683 0.0490142182757818 no 271 0.0624444964359127 379 3652836 SGTC_942 3253-1115 227 µM 1.5273538300545 0.0497976905043213 no 272 0.063336525309706 402 46497897 SGTC_1106 tegaserod maleate 11.7 µM 1.52451027683298 0.0501090639400924 no 273 0.0636906458207853 436 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_400 oxethazaine 37.5 µM 1.5207208195722 0.0505264257273016 no 274 0.0641649559015586 397 4621 A local anesthetic. SGTC_2326 6164455 177.58 µM 1.51622097182137 0.0510256198185589 no 275 0.0647317434163 393 2888790 SGTC_2884 9058502 51.95 µM 1.5144179975856 0.0512267323813858 no 276 0.064959928713397 423 6471554 SGTC_2271 7849410 118.62 µM 1.50962726014558 0.0517641797395067 no 277 0.0655692807236802 390 972430 SGTC_1989 st071868 50.2 µM 1.50898070712471 0.0518370550870694 no 278 0.0656518565880215 446 16414057 SGTC_1974 st069448 26.9 µM 1.50786374699899 0.0519631438135571 no 279 0.0657947014023242 373 6323587 YNR016C ACC1 SGTC_541 4513-1321 94 µM 1.50117288542757 0.0527235554545043 no 280 0.0666554255538936 425 747515 SGTC_2655 perillic acid 100 µM 1.50054072177851 0.0527958545580023 no 281 0.0667371966811843 350 5702197 An apoptosis inducer. SGTC_2033 5192550 145 µM 1.50010945423863 0.0528452227519356 no 282 0.0667930261827381 381 182073 SGTC_1827 berberine 7.24 µM 1.4984238104923 0.0530385336708924 no 283 0.0670115869773813 383 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3029 9088683 49.47 µM 1.49775809052581 0.0531150332394027 no 284 0.0670980565294837 399 25236615 SGTC_2847 9005661 71.43 µM 1.49693680031107 0.0532095302908257 no 285 0.0672048517690158 277 2991449 SGTC_2086 5274770 176.623 µM 1.49213852010014 0.0537642835636985 no 286 0.0678314177494085 412 689278 SGTC_2094 5332512 191.667 µM 1.48920106459641 0.0541061515596227 no 287 0.0682172152808607 440 755774 SGTC_2036 5160441 105 µM 1.4856217968863 0.0545250380348057 no 288 0.0686895931521392 513 134534 YIL048W NEO1 SGTC_1829 berberine 14.4 µM 1.47738005101352 0.0554993326358762 no 289 0.0697868952775036 422 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1015 4130-4525 82 µM 1.47620995962582 0.0556387618003198 no 290 0.0699437683345091 450 1363237 SGTC_2056 5235370 200 µM 1.47126501637228 0.0562310611382758 no 291 0.0706097301517914 456 5511916 SGTC_2062 5245942 200 µM 1.46599925374776 0.0568672416292512 no 292 0.0713242450807045 459 1376160 SGTC_1023 4482-3888 16 µM 1.46562787983634 0.0569123220943993 no 293 0.0713748458191356 416 3303168 SGTC_617 3770-0098 35 µM 1.46379119094079 0.0571356886033873 no 294 0.0716255050404161 421 5962639 SGTC_1571 st070080 73.4 µM 1.46333670539025 0.0571910666308652 no 295 0.0716876343519258 434 4315245 SGTC_1267 0828-0272 9.49 µM 1.46217154524185 0.0573332317221383 no 296 0.0718471035102334 491 745334 SGTC_679 0422-0091 41.4 µM 1.46048134312877 0.0575399530239168 no 297 0.0720789156979292 482 627384 YHR062C RPP1 SGTC_889 0919-1524 82.7 µM 1.45902959510429 0.0577179776814292 no 298 0.0722784811363662 425 3905452 SGTC_2682 pyrogallin 40.03 µM 1.45703807458228 0.0579628976910012 no 299 0.0725529352348831 497 822798 An ATP competetive kinase inhibitor. SGTC_2681 menadione 3.18 µM 1.45615197100968 0.0580721342072148 no 300 0.0726753066512193 443 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1723 st034307 2.5525 µM 1.45457321733179 0.0582671596145949 no 301 0.0728937250417253 436 867466 SGTC_2214 7179297 48.276 µM 1.45322632807687 0.0584339489008504 no 302 0.0730804622328648 391 769744 SGTC_1939 st074455 53.6 µM 1.44807574510068 0.0590752213194189 no 303 0.073797934043872 473 1644229 SGTC_1863 st057641 20.1 µM 1.44748555936001 0.0591490534489586 no 304 0.0738804890140181 487 3921635 SGTC_1233 0325-0408 14.2 µM 1.44560329047636 0.0593850084915297 no 305 0.074144251605168 457 12874 SGTC_754 3474-0146 171 µM 1.4376444823206 0.0603908641837357 no 306 0.075267476431444 427 24762078 SGTC_1047 2043-3044 82 µM 1.43690749630412 0.0604846769009579 no 307 0.0753721398092612 480 669592 SGTC_688 0527-0193 473 µM 1.43263348547186 0.0610309758529663 no 308 0.075981303527031 429 4007154 SGTC_41 0478-0632 82.643 µM 1.42721281917578 0.0617293779008264 no 309 0.0767592802889782 543 3750424 SGTC_3284 9108171 64.8615 µM 1.42370481269844 0.0621846668489467 no 310 0.0772659699855491 423 8687505 SGTC_3178 9107506 49.47 µM 1.41798013776918 0.0629332676643565 no 311 0.0780982818720243 462 8897194 SGTC_2 0422-0095 29 µM 1.41644543020784 0.0631351460109966 no 312 0.0783225653226097 356 6790840 SGTC_2485 5633444 17.78 µM 1.4155506410113 0.0632530808022338 no 313 0.078453555774975 468 5724239 SGTC_3348 9149464 3.537 µM 1.41474841829455 0.0633589609291438 no 314 0.078571136329491 467 1951442 SGTC_1256 0570-0116 285 µM 1.40992865650577 0.0639979967787591 no 315 0.0792803750299465 445 410638 SGTC_885 0865-0106 16.8 µM 1.40798200822012 0.0642575126815133 no 316 0.0795681988056268 483 2793380 SGTC_3035 9091303 49.47 µM 1.40227848372222 0.0650225835579027 no 317 0.0804160514727798 422 25237002 SGTC_2482 5981709 142.65 µM 1.39766670056278 0.0656463625147908 no 318 0.0811065891605559 530 877755 SGTC_1652 st011932 78 µM 1.39690288728065 0.065750120461745 no 319 0.0812213881242133 461 1551076 SGTC_3291 9121177 71.43 µM 1.39634622043915 0.0658258192669282 no 320 0.0813051307685193 399 17015612 SGTC_1660 st012960 28.1 µM 1.39627811986756 0.0658350846154465 no 321 0.0813153800052258 487 24207266 SGTC_2914 7968218 45.32 µM 1.39563860680667 0.065922142183938 no 322 0.0814116752223628 432 2977111 SGTC_36 0335-0881 14.2 µM 1.39315269069019 0.0662614001026407 no 323 0.0817868112222035 560 23828853 SGTC_2890 9046729 58.44 µM 1.39160935219575 0.0664727019216375 no 324 0.0820203626517929 419 903329 SGTC_1889 st059080 5.18 µM 1.39041691529461 0.0666363179811234 no 325 0.0822011564347985 518 176925 Isolated from Daphnopsis sellowiana. SGTC_840 0245-0196 390 µM 1.38922669393777 0.0667999406927872 no 326 0.0823819134696183 538 3827528 SGTC_506 n9-isopropylolomoucine 153 µM 1.38890664265878 0.0668439919351598 no 327 0.0824305701734402 462 6610355 SGTC_1365 1672-3266 55.4 µM 1.38497143163925 0.0673874655518314 no 328 0.0830306015223781 510 6415873 SGTC_1673 st016611 27.3 µM 1.38294334857465 0.0676688850870358 no 329 0.0833411186053857 513 5226799 SGTC_1177 0983-0204 23.6 µM 1.38173368375143 0.067837171570894 no 330 0.0835267439248019 528 766818 SGTC_3352 9151559 45.5865 µM 1.37770717714309 0.0683996613916238 no 331 0.0841468572702519 480 17159339 SGTC_756 0508-1999 28.3 µM 1.37550068217542 0.068709424164478 no 332 0.0844881371856441 477 6753853 SGTC_1278 0874-0585 172 µM 1.36830959816742 0.0697264682171298 no 333 0.0856075938394645 497 766306 SGTC_122 0236-0016 402.397 µM 1.36761887721421 0.0698247645626746 no 334 0.0857157022276476 570 6808838 SGTC_1682 st012968 530 nM 1.36365234690299 0.07039130659902 no 335 0.086338504280351 456 24207270 SGTC_1622 st003707 19.4 µM 1.36257712349289 0.0705454886935959 no 336 0.0865079113237393 541 10140899 SGTC_828 2074-0507 139 µM 1.35841446437253 0.0711448435986497 no 337 0.087166103558787 530 X828 SGTC_452 diindolylmethane 8 µM 1.35718528207069 0.0713225714455914 no 338 0.0873611730195323 445 3071 Inhibits expression of several cancer promoting factors. SGTC_2990 9074105 71.4286 µM 1.35213201351358 0.072056807380196 no 339 0.0881665438910108 459 6502001 SGTC_821 1114-0266 29.2 µM 1.34477286995796 0.0731364311636121 no 340 0.0893492970197112 490 3123235 SGTC_1347 1493-0251 600 nM 1.3409867627521 0.0736966729195113 no 341 0.0899623752176532 559 3986378 SGTC_2215 7188065 200 µM 1.33805664904822 0.0741324980795061 no 342 0.0904389854618219 440 940217 SGTC_3205 9113483 49.47 µM 1.33137035369638 0.0751343869192216 no 343 0.0915335896421774 564 17018033 SGTC_1620 st003704 16.5 µM 1.33136126262547 0.0751357561387025 no 344 0.0915350845831492 524 2834414 SGTC_90 0870-0863 4.608 µM 1.32727652897949 0.0757528907341199 no 345 0.0922086124956473 569 1738164 SGTC_2443 5493264 126.67 µM 1.32407935269896 0.0762386181769582 no 346 0.092738346008881 518 5340055 SGTC_3299 9121982 43.1275 µM 1.31862357851099 0.0770729488763636 no 347 0.093647493515907 545 17594604 YPL160W CDC60 SGTC_3337 9144342 33.5465 µM 1.31653291776032 0.0773944982002644 no 348 0.0939976187228024 525 17682949 SGTC_1124 fisetin 1.16336 µM 1.31175447877595 0.078133259763493 no 349 0.0948014943208618 489 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1616 st002734 56.1 µM 1.30964358528066 0.0784613088586347 no 350 0.095158218265424 557 4026101 SGTC_287 k060-0039 29.6 µM 1.30642950753457 0.0789628051509837 no 351 0.0957032683590089 526 5861974 SGTC_2803 7707263 71.43 µM 1.3047657935077 0.0792233482151179 no 352 0.0959863050907304 517 2199229 SGTC_1740 st038286 13.222 µM 1.3041704048319 0.0793167460050958 no 353 0.0960877440666495 544 716786 SGTC_1513 0337-0559 19 µM 1.29943847376517 0.080062003265856 no 354 0.0968967476717996 491 775073 SGTC_2315 7733312 200 µM 1.29589056560254 0.0806242461302841 no 355 0.097506595022755 499 726316 SGTC_1284 0929-0043 16 µM 1.29344910671356 0.0810128768524036 no 356 0.0979278876578008 568 1239883 SGTC_1886 st057356 49.9 µM 1.29096584646577 0.0814096102297293 no 357 0.0983577603711797 521 24207747 SGTC_3292 9120825 59.784 µM 1.28654076781503 0.0821202041288979 no 358 0.0991272002300674 558 24824900 SGTC_3180 9109287 49.47 µM 1.28540545142135 0.0823032679908942 no 359 0.099325318610814 497 18891271 SGTC_3000 9075062 71.4286 µM 1.28540180725452 0.0823038560882386 no 360 0.0993259550018815 526 17057871 SGTC_1182 1222-0449 220 µM 1.28536522340909 0.0823097601816515 no 361 0.0993323439065309 527 658318 SGTC_2437 5741531 144.16 µM 1.28358840364113 0.0825968967805044 no 362 0.0996430046961042 592 2262990 SGTC_2515 chrysin 20.77 µM 1.28004194205612 0.0831722632479617 no 363 0.100265192749629 571 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1028 k015-0029 4.8 µM 1.27989332738471 0.0831964396381662 no 364 0.100291327340371 592 4588309 SGTC_2269 7935389 174.42 µM 1.27748361313835 0.0835891857808605 no 365 0.10071578105634 561 97605 SGTC_64 000l-0018 272.079 µM 1.27577131720617 0.083869109067285 no 366 0.101018184823165 676 6811119 SGTC_149 3970-0822 46.1 µM 1.27294569789685 0.0843325751735259 no 367 0.101518655853479 718 3114250 YBL034C STU1 SGTC_2397 5161689 200 µM 1.2710762585882 0.0846402606517147 no 368 0.101850760268433 601 2259942 SGTC_1169 aniline yellow 25.8 µM 1.27036214347298 0.0847580167241847 no 369 0.101977830763417 529 6051 A DNA damaging agent. SGTC_1748 st037455 53.6035 µM 1.26883497733791 0.0850102554033182 no 370 0.102249963614894 570 580690 SGTC_2833 9001315 45.46 µM 1.26711779688863 0.0852945498732831 no 371 0.102556586447311 589 2989378 SGTC_1474 0330-0125 5.35 µM 1.2645530875594 0.0857204857687673 no 372 0.103015789447146 578 X1474 SGTC_2572 astragaloside iv 100 µM 1.26421009447316 0.0857775690874021 no 373 0.103077314309321 554 45006101 An anti-inflammatory agent. SGTC_353 1988-1175 58.3 µM 1.26136991518553 0.0862513454466872 no 374 0.103587801133238 535 2788357 SGTC_1340 1486-1359 257 µM 1.26105033310716 0.0863047778783408 no 375 0.103645356657305 585 4309068 SGTC_579 4491-1009 110 µM 1.25842653936352 0.0867443985678307 no 376 0.10411876944751 723 1271041 SGTC_1226 3909-7979 35.4 µM 1.25721167811931 0.0869485163325091 no 377 0.104338497837881 634 6615510 SGTC_721 1187-1332 279 µM 1.25610084758671 0.0871354689683539 no 378 0.104539704441163 483 25730 SGTC_2939 9044578 71.43 µM 1.25607670804604 0.0871395349799209 no 379 0.104544079995186 562 2653634 SGTC_2737 bleomycin 30.5 nM 1.25444472728348 0.0874147509589049 no 380 0.104840201998816 639 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1318 1280-3875 124 µM 1.25137010176831 0.0879350151856147 no 381 0.10539974007852 618 373245 SGTC_3265 9137266 49.47 µM 1.2508676294093 0.0880202587211731 no 382 0.1054913878718 506 17224265 SGTC_492 tmb-8 126 µM 1.2489780818102 0.0883413686278398 no 383 0.105836545322515 403 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2936 9038235 15.59 µM 1.2471157169523 0.0886587125376403 no 384 0.106177535408654 566 4749415 SGTC_1230 0170-0365 3.77 µM 1.24282904644901 0.0893923791854113 no 385 0.106965418231167 741 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1774 st048371 48.465 µM 1.24101775113652 0.0897037373419938 no 386 0.107299595697193 615 4242727 SGTC_1090 efavirenz 20.7 µM 1.23977448539096 0.0899179184802266 no 387 0.107529408964691 580 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_804 1595-0054 20.9 µM 1.23693442877957 0.0904086088989081 no 388 0.108055713510677 565 761523 Stimulates phospholipase C. SGTC_3148 9097893 49.47 µM 1.23634883880966 0.0905100309222323 no 389 0.108164462246335 571 17174100 SGTC_3210 9128157 49.47 µM 1.23603821207081 0.0905638646034979 no 390 0.108222180082659 560 17590849 SGTC_3160 9100216 49.47 µM 1.23039049910943 0.0915467996496565 no 391 0.109275454719828 594 17191039 SGTC_1679 SEC14.276 6.7 µM 1.22831108726799 0.0919106873850505 no 392 0.109665105240572 663 1005053 YMR079W SEC14 SGTC_2245 6637752 200 µM 1.2273969315217 0.0920709990895169 no 393 0.10983671957336 513 681890 SGTC_3173 9105693 49.47 µM 1.22715607581325 0.0921132713956869 no 394 0.109881967447732 618 17096658 SGTC_3344 9148862 3.898 µM 1.22702479153615 0.0921363189967211 no 395 0.109906636537342 602 4905352 SGTC_2331 7980721 200 µM 1.22612708141418 0.0922940308414752 no 396 0.110075428072193 603 2981221 SGTC_2388 9080168 200 µM 1.22458532028459 0.0925653571865058 no 397 0.110365750823491 563 15943073 SGTC_816 0325-0417 81.3 µM 1.22194319936431 0.0930317013131336 no 398 0.110864553778981 577 68101 SGTC_3238 9133470 49.47 µM 1.22123762159197 0.0931565317101557 no 399 0.110998031811506 583 3534688 SGTC_3107 9121808 49.47 µM 1.21789055299449 0.0937503797014802 no 400 0.111632783327545 505 662681 SGTC_737 1950-0117 57.9 µM 1.21629491106779 0.0940344655278587 no 401 0.111936299700084 591 5393513 SGTC_3325 9138760 55.175 µM 1.215033304191 0.0942595294971766 no 402 0.112176694692849 604 43844959 SGTC_1521 st012942 49.4 µM 1.21463503802706 0.0943306605110434 no 403 0.11225265956111 661 24207259 SGTC_2513 baicalein 25.65 µM 1.21276422654666 0.0946653203991227 no 404 0.112609988122851 614 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2965 9082772 38.63 µM 1.2115181363814 0.0948887121379489 no 405 0.112848444034341 644 16459634 SGTC_1852 st056254 31.4 µM 1.20894188084928 0.0953517992794645 no 406 0.113342587325386 594 442583 SGTC_1171 0368-0077 21.4 µM 1.20586372357535 0.0959072832439916 no 407 0.113935020033279 576 3239779 SGTC_531 3788-1495 174 µM 1.20579405482108 0.0959198831458984 no 408 0.113948454207028 609 2896655 SGTC_777 1315-0167 517 µM 1.20516845511044 0.0960330801689003 no 409 0.114069138703474 584 4221767 SGTC_1725 st036284 20.55 µM 1.20446275166285 0.096160889155058 no 410 0.114205385273681 683 707914 SGTC_2619 obliquin 87.91 µM 1.20291030783626 0.0964424901673211 no 411 0.114505515513003 704 6708593 A bioactive alkalod. YER133W GLC7 SGTC_537 1334-0398 209 µM 1.20280238641549 0.0964620887603109 no 412 0.114526400553728 644 5846986 SGTC_1280 0880-0253 10.1 µM 1.20181598743564 0.0966413550119464 no 413 0.114717414933506 637 6836607 SGTC_629 3448-6466 76.7 µM 1.1983644180422 0.0972705627974313 no 414 0.115387589175464 640 573744 SGTC_3227 9130768 49.47 µM 1.19744394092297 0.0974388687920434 no 415 0.115566782708875 623 17720899 SGTC_153 4077-0274 519.67 µM 1.194229276651 0.0980283344463224 no 416 0.11619414692579 575 3121976 SGTC_1031 k035-0009 16 µM 1.19348841589077 0.0981645541238806 no 417 0.116339073133979 682 5180959 SGTC_1629 st005085 44.9 µM 1.18892537050402 0.0990066048105596 no 418 0.117234517798396 635 24207091 SGTC_2488 5268135 45.7 µM 1.18252648139717 0.100196319105116 no 419 0.118498432198349 723 1270356 YLR208W SEC13 SGTC_2706 st078239 82.5 µM 1.18032600721784 0.100607844434844 no 420 0.118935289112302 647 15434492 SGTC_1043 0916-0009 19.3 µM 1.17865961053591 0.100920307774345 no 421 0.119266872315358 737 3101130 SGTC_363 0455-0021 3.06 µM 1.17636449038846 0.10135181945607 no 422 0.119724627591664 661 4597466 SGTC_1188 1403-0014 4.57 µM 1.17391568854727 0.101813705718058 no 423 0.120214398910809 702 9614867 SGTC_3281 9140613 49.47 µM 1.17220654397457 0.102136986535112 no 424 0.120557070867751 591 16013766 SGTC_822 1487-0950 154 µM 1.16481995710387 0.103542731405092 no 425 0.122045939403712 647 1958375 SGTC_3231 9132313 49.47 µM 1.16175117252916 0.104130863259221 no 426 0.122668276443712 660 4905967 SGTC_657 3534-0529 86.7 µM 1.15248661726878 0.105921097428863 no 427 0.124560582965462 670 1049549 SGTC_1486 3970-0793 4.53 µM 1.15149133131412 0.106114736418384 no 428 0.12476507975358 665 2844330 SGTC_2694 st077685 81.9 µM 1.14975555515412 0.106453054021746 no 429 0.125122282772366 651 2838096 SGTC_2597 laccaic acid a 100 µM 1.14331979833291 0.107714233803851 no 430 0.126452918916587 685 5491415 A textile dye. SGTC_3270 9137563 49.47 µM 1.14327881099291 0.10772230021451 no 431 0.126461424799701 598 17015724 SGTC_3228 9131799 49.47 µM 1.14115823310565 0.108140229089848 no 432 0.12690204085207 654 17015818 SGTC_233 rapamycin 362 pM 1.14028847792924 0.108311979765177 no 433 0.127083068243736 690 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.13872462758311 0.108621287147168 no 434 0.127409013726057 651 2724278 An inhibitor of dopamine biosynthesis. SGTC_2540 epiandrosterone 100 µM 1.13573046983539 0.109215260616072 no 435 0.128034692174887 811 441302 A steroid. SGTC_2581 avocatin a 64 µM 1.13476835216475 0.109406617620579 no 436 0.128236194843955 702 6710728 A skin care supplement. SGTC_33 0986-0033 35.816 µM 1.13444790006366 0.109470406243262 no 437 0.128303358111402 634 2848082 SGTC_2801 7907800 81.82 µM 1.13334115462024 0.109690918429652 no 438 0.128535507721823 700 6620925 SGTC_3334 9142812 21.919 µM 1.13112499722414 0.110133432279813 no 439 0.129001242221163 672 45283678 SGTC_2537 larixol 68.93 µM 1.13094175102521 0.110170079420778 no 440 0.129039804471157 732 6708759 SGTC_1444 4112-3581 28 µM 1.12909302452227 0.110540292891819 no 441 0.129429296796848 685 2877249 SGTC_1828 st055811 49 µM 1.11719895358353 0.112943454173601 no 442 0.131954633968351 646 5877589 SGTC_1971 st069429 63.5 µM 1.11567255242451 0.113254538444092 no 443 0.13228116178953 664 1246522 YGL099W LSG1 SGTC_1076 itraconazole 331 nM 1.11509687432162 0.113372021635219 no 444 0.132404455401017 701 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1626 st003712 1.76 µM 1.11436440757931 0.11352162754805 no 445 0.132561443061743 652 24207035 SGTC_1260 0700-1617 7.75 µM 1.11423393775557 0.113548290698556 no 446 0.132589419764186 705 2853078 SGTC_418 lividomycin a 100 µM 1.11261870367127 0.113878753988764 no 447 0.132936112040949 749 72394 An antibiotic. SGTC_2292 7671323 168.05 µM 1.11199304906042 0.114006941621505 no 448 0.133070569487752 691 937504 SGTC_2814 7977482 42.97 µM 1.10428333911257 0.115594993844334 no 449 0.13473512390344 761 6456762 SGTC_2561 acetosyringone 100 µM 1.10414859925759 0.115622886694916 no 450 0.134764341201491 812 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_854 0422-0053 192 µM 1.09994566437666 0.116495348998054 no 451 0.135677898433966 683 3596728 SGTC_2812 7970281 58.44 µM 1.09874847227481 0.116744719290814 no 452 0.135938896675455 705 2233435 SGTC_2496 diffractaic acid 79.83 µM 1.09552292672361 0.11741847014773 no 453 0.136643803451585 744 94870 An apoptosis inducer which activates caspases. SGTC_410 α-linolenic acid 100 µM 1.09535331084344 0.117453975498723 no 454 0.136680940143566 739 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2466 5983409 37.09 µM 1.09533388561656 0.117458042227501 no 455 0.136685193656626 680 2879657 SGTC_666 0272-0154 136 µM 1.09529795297871 0.117465565094438 no 456 0.136693062011478 740 6870312 SGTC_1897 st060201 15 µM 1.09467266957127 0.117596529224935 no 457 0.136830033124938 663 611878 SGTC_663 1486-0733 13.9 µM 1.09419766611665 0.117696086635335 no 458 0.136934147429429 747 722445 YPR165W RHO1 SGTC_113 0099-0221 2.5 µM 1.09202267394389 0.118152711730614 no 459 0.137411567582904 691 89219 SGTC_1126 isoteolin 1.0172 µM 1.09145342819531 0.11827242765886 no 460 0.1375367069083 688 133323 SGTC_938 3126-1755 342 µM 1.09079365522415 0.118411289301635 no 461 0.137681844466707 755 1777771 SGTC_2476 5806916 10.51 µM 1.08901556111625 0.118786096359657 no 462 0.138073511787431 701 2870194 SGTC_1081 sertraline 6 µM 1.08852068533083 0.118890560867683 no 463 0.138182654929221 741 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3295 9122362 53.5725 µM 1.08802931802776 0.118994348940048 no 464 0.138291082472777 678 4730473 SGTC_941 3237-0776 460 µM 1.08774780243206 0.119053840325699 no 465 0.13835322922477 671 760008 SGTC_1887 st057648 70.8 µM 1.08585887673167 0.119453561438175 no 466 0.138770716588876 729 688672 SGTC_1691 st019933 84.6 µM 1.08316414081394 0.120025439886637 no 467 0.139367786614638 706 6176082 SGTC_276 colchicine 750 µM 1.08162556060572 0.120352822365164 no 468 0.139709471014892 737 2833 A microtubule depolymerizer. SGTC_75 0159-0059 199.013 µM 1.07946991268571 0.120812563100173 no 469 0.140189149669406 692 5377270 SGTC_1753 st043925 64 µM 1.07811286942042 0.121102616521534 no 470 0.140491694536978 746 670181 SGTC_1947 st076332 61.6 µM 1.07781645448685 0.121166037161828 no 471 0.140557837455732 668 24208416 SGTC_1239 0337-0584 35.4 µM 1.07524872907071 0.121716402899681 no 472 0.141131692044058 794 914301 YML130C ERO1 SGTC_2661 dactinomycin 12.96 µM 1.07356730215595 0.122077749992516 no 473 0.14150832957136 765 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1254 0550-0035 264 µM 1.07190814831178 0.122435048244842 no 474 0.141880644988102 779 15121435 SGTC_1991 st073000 8.92 µM 1.07060138073242 0.122716976380709 no 475 0.142174351192307 780 4301969 YIL048W NEO1 SGTC_1747 st037496 66.6 µM 1.06780473510415 0.123321866981949 no 476 0.142804300852682 755 723305 SGTC_2520 obtusaquinone 4.71 µM 1.06639214251297 0.123628191509073 no 477 0.143123206075479 740 5967872 SGTC_2468 5987765 72.9 µM 1.06546063901462 0.123830481859685 no 478 0.143333764229711 772 26772094 SGTC_2161 5662504 8.5105 µM 1.06136860730832 0.124721873817585 no 479 0.144261208867622 704 2859334 SGTC_1813 st051246 8.6015 µM 1.06040494391167 0.124932445207333 no 480 0.144480206990042 713 5291959 SGTC_383 2324-0395 7.37 µM 1.05949629089477 0.125131223590889 no 481 0.144686908778091 741 3146421 SGTC_729 4092-0585 94.1 µM 1.05937420470643 0.125157948182626 no 482 0.144714696303724 684 2169061 SGTC_2078 5212016 200 µM 1.05710832627474 0.125654671148829 no 483 0.145231075822037 711 1899708 SGTC_982 1491-0518 27.5 µM 1.05467665942918 0.126189266289203 no 484 0.145786615071527 686 3091256 SGTC_1645 Cervolide 78 µM 1.05010400234023 0.127198840998822 no 485 0.146835149400706 719 23173 A fragrance. SGTC_3221 9128209 49.47 µM 1.04926835178662 0.127383945860632 no 486 0.147027313840401 721 16460723 SGTC_2074 5212007 75.395 µM 1.04826355499514 0.127606766252381 no 487 0.147258597994992 702 758611 SGTC_2945 9067681 61.76 µM 1.04722204200163 0.127838014558577 no 488 0.147498590746708 730 16456930 SGTC_2533 agelasine 13.65 µM 1.0448187651338 0.12837272766497 no 489 0.148053370166976 784 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1690 st023502 41.2 µM 1.04458957619345 0.128423801659325 no 490 0.14810634965368 736 24207482 SGTC_1234 0326-0494 15.5 µM 1.04157569789658 0.129096747008976 no 491 0.14880422032807 765 1547813 SGTC_414 piperonyl butoxide 100 µM 1.0407172216062 0.12928887606093 no 492 0.149003404036439 738 5794 A potent inhibitor of cytochrome P450. SGTC_1769 st044406 64.4 µM 1.03959044717542 0.12954135151688 no 493 0.149265108486909 774 670903 SGTC_1034 k072-0165 12.7 µM 1.03786012547771 0.129929727962895 no 494 0.149667589928945 804 5835461 SGTC_696 1560-0013 611 µM 1.03779081243169 0.129945302280056 no 495 0.149683727558067 769 1650269 SGTC_1330 1469-0054 61.8 µM 1.03631398795641 0.1302774449695 no 496 0.150027841238817 813 7102664 SGTC_2751 anetholtrithion 17.25 µM 1.03466826189164 0.130648265602107 no 497 0.150411931462553 750 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2952 9073731 13.78 µM 1.03398620073772 0.130802163644241 no 498 0.150571307173979 793 16457353 SGTC_3084 9116877 49.47 µM 1.02925157832124 0.131873921998002 no 499 0.15168073536631 718 27241325 SGTC_2302 7771753 200 µM 1.02835593606949 0.132077344539803 no 500 0.151891213957624 771 2203047 SGTC_1467 k284-1082 293 µM 1.02787836663605 0.132185900791465 no 501 0.152003523472852 812 3334705 SGTC_608 k048-0125 159 µM 1.02509963002443 0.132818755215526 no 502 0.152658090048053 799 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2600 tangeritin 87.95 µM 1.02359779563624 0.133161663658088 no 503 0.153012643421373 713 68077 A bioactive flavone. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.02337214792014 0.133213237589345 no 504 0.153065961514293 816 23847180 SGTC_2858 9025781 8.96 µM 1.02214691949965 0.133493515126363 no 505 0.153355684576578 869 4894980 YPL153C RAD53 SGTC_2204 7233102 200 µM 1.02157231520453 0.133625098530178 no 506 0.153491683170938 732 2172480 SGTC_2968 9090663 33.37 µM 1.02109561902398 0.133734328804768 no 507 0.153604569263619 768 25236811 SGTC_898 1000-0849 28.3 µM 1.02071835236094 0.133820819278452 no 508 0.153693948481836 806 6751807 SGTC_152 4469-0003 551.229 µM 1.01741371263709 0.134580069680403 no 509 0.154478330705661 778 697280 SGTC_1468 k284-1086 134 µM 1.01433732026701 0.13528953235163 no 510 0.155210910909349 841 15996457 SGTC_303 1348-1668 34.2 µM 1.01014143193231 0.136261294210609 no 511 0.156213767266441 786 5380509 SGTC_1211 1056-0033 32.3 µM 1.00838490180027 0.136669518935264 no 512 0.156634859135151 825 6741922 SGTC_1210 3013-0140 750 nM 1.00831056573281 0.136686813362452 no 513 0.156652696138778 847 905973 SGTC_1908 st060353 56.5 µM 1.00802696373671 0.136752807648637 no 514 0.156720758963446 853 4227716 SGTC_2308 7584454 197.62 µM 1.0073850264848 0.136902267121736 no 515 0.156874892036684 831 893577 SGTC_1096 rimcazole 32.2 µM 1.00550216971699 0.137341288285279 no 516 0.157327552615471 759 18528119 A dopamine reuptake inhibitor. SGTC_578 3460-0051 92 µM 1.00423904266409 0.137636346830553 no 517 0.157631703744629 912 2876744 SGTC_2364 9055074 200 µM 1.00320291708218 0.137878702035123 no 518 0.157881482912241 755 6470630 SGTC_392 N-ethylmaleimide 8.33 µM 1.0007382944103 0.13845635953843 no 519 0.15847667424462 765 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2316 5844804 197.44 µM 0.999652216720785 0.138711436880259 no 520 0.158739421937072 956 776813 SGTC_1557 sumaresinolic acid 42.3 µM 0.998498255565099 0.138982807927912 no 521 0.159018904970896 744 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2795 7780010 54.55 µM 0.99624804440834 0.13951301739888 no 522 0.15956482047194 757 953673 SGTC_3274 9138298 49.47 µM 0.995633664741608 0.139658020326358 no 523 0.159714085801936 865 17015756 SGTC_96 0929-0093 37.281 µM 0.99300060001313 0.140280624005753 no 524 0.160354831035509 777 6991579 SGTC_468 gf-109203x 121 µM 0.989798045259607 0.141040424150658 no 525 0.161136420234676 680 2396 A protein kinase C inhibitor. SGTC_2731 amoxapine 43.43 µM 0.989410399632665 0.141132581355295 no 526 0.161231194205082 746 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_214 4373-3496 70 µM 0.988010636382987 0.141465694915349 no 527 0.161573719536284 980 3779166 SGTC_2866 9034245 58.44 µM 0.98706938741342 0.141689991294747 no 528 0.161804311904671 801 6462273 SGTC_767 0929-0023 86 µM 0.986644010192363 0.141791436207465 no 529 0.161908593485543 899 1204563 SGTC_2973 9094665 17.96 µM 0.985650835912253 0.142028482090561 no 530 0.162152241410555 870 25237061 YIL048W NEO1 SGTC_2727 riluzole 51.77 µM 0.983710779425087 0.142492298540641 no 531 0.162628869111159 761 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1464 k208-0027 110 µM 0.981613898798297 0.142994758313607 no 532 0.16314504879415 845 X1464 SGTC_2170 morpholine 200 µM 0.980555036949965 0.143248939813055 no 533 0.163406108197574 837 121171 Reacts with secondary amines. SGTC_98 0074-0023 107.663 µM 0.980477146899522 0.143267649487396 no 534 0.163425322478218 850 3563821 SGTC_1141 3253-0389 52.6 µM 0.979940042589 0.143396710208517 no 535 0.163557857820511 822 5402031 SGTC_1388 3346-4487 254 µM 0.979814554813505 0.143426874958207 no 536 0.16358883311869 871 3345614 SGTC_1808 st050063 61.5 µM 0.977725783545983 0.143929602926229 no 537 0.164104983004107 825 4011993 SGTC_895 0964-0006 13.7 µM 0.97750806078672 0.143982073019942 no 538 0.164158844537146 814 6738897 SGTC_2051 5263410 176 µM 0.976950638914414 0.144116467688032 no 539 0.164296795077718 843 227584 SGTC_596 1155-0152 116 µM 0.976576274350708 0.14420677462054 no 540 0.164389484849834 857 280313 SGTC_3149 9097855 49.47 µM 0.975364541598039 0.14449933911582 no 541 0.16468973290588 817 25236625 YMR079W SEC14 SGTC_210 3551-0445 56.827 µM 0.974841906529963 0.144625649101539 no 542 0.164819343143058 824 2865180 YOR207C RET1 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.974640910352078 0.144674245478043 no 543 0.164869206527387 776 5282362 SGTC_1731 st035964 63 µM 0.97208671505083 0.145292750670665 no 544 0.165503705329361 793 6739575 SGTC_1186 1319-0216 26 µM 0.971102171854963 0.145531634759055 no 545 0.165748701200111 881 4565136 SGTC_926 2268-1401 59.4 µM 0.969825388437686 0.145841819543314 no 546 0.166066767778683 829 2931578 SGTC_2835 9006588 71.43 µM 0.96934298634471 0.145959131019721 no 547 0.166187044211706 757 2345538 SGTC_1694 st024011 44.9 µM 0.966931776005597 0.146546444144314 no 548 0.16678907017514 881 2787533 SGTC_393 acivicin 6.25 µM 0.966898880209767 0.146554467724974 no 549 0.166797293245843 777 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.965212596530652 0.146966162453117 no 550 0.167219169483016 887 16623 A steroid. SGTC_2002 4023503 131 µM 0.964983302512496 0.147022202877896 no 551 0.167276587580607 954 4736863 YCR052W RSC6 SGTC_2922 7999257 32.47 µM 0.964596440186897 0.147116786141289 no 552 0.167373491561483 767 2988377 SGTC_343 4130-2827 29.8 µM 0.964126406828771 0.147231758621854 no 553 0.167491277471594 846 1118244 SGTC_2908 7930301 100 µM 0.963958949025846 0.147272734174573 no 554 0.16753325371063 894 2223178 SGTC_2176 5809774 33.9695 µM 0.961349629684784 0.147912200691052 no 555 0.168188200819813 877 2870539 SGTC_3312 9133330 71.43 µM 0.960348428464563 0.148158058022092 no 556 0.1684399420797 907 17617324 SGTC_877 0771-0151 33.1 µM 0.957521724212761 0.148853665297832 no 557 0.169151993363306 863 6166523 SGTC_3059 1327-0034 3 µM 0.956657581349589 0.149066752077599 no 558 0.169370057509583 825 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1693 xanthone 101.9 µM 0.949220064925076 0.150909171403392 no 559 0.171254349284062 884 7020 An insecticide. SGTC_1243 0416-0003 5.65 µM 0.94904211369509 0.150953438300242 no 560 0.17129959672335 820 2141977 SGTC_1685 st024049 53.0905 µM 0.943192495143101 0.152413392616805 no 561 0.172791225698609 839 1941139 SGTC_719 2810-4230 27.3 µM 0.942623424776397 0.152555920347469 no 562 0.172936776888984 830 721079 SGTC_345 1362-0200 395 µM 0.942592262027449 0.152563727833266 no 563 0.172944749644197 825 1419823 SGTC_2284 7945075 39.21 µM 0.941494269509756 0.152838987078467 no 564 0.173225812269798 943 1245402 SGTC_1426 4048-4480 71.7 µM 0.940411054163032 0.153110864310449 no 565 0.173503377113057 884 14224343 SGTC_40 0327-0103 19.753 µM 0.939893458777305 0.153240889169327 no 566 0.173636106472183 826 409036 SGTC_307 1501-1223 22.3 µM 0.939597618636037 0.153315239864341 no 567 0.173711999124536 844 2830329 SGTC_2475 5812728 15.03 µM 0.936566493106952 0.154078400640126 no 568 0.174490797151726 948 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3246 9135460 32.98 µM 0.936087501286183 0.154199228222667 no 569 0.174614068851981 795 41446951 SGTC_2671 danthron 100 µM 0.930524643626165 0.155607070413197 no 570 0.176049755351875 862 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3083 9117465 49.47 µM 0.929769783946112 0.155798760748934 no 571 0.176245147083126 884 16420915 SGTC_1208 2323-2347 50.3 µM 0.928551838517806 0.156108375995863 no 572 0.176560695520108 899 5412760 SGTC_2652 actinonin 100 µM 0.928360266807024 0.15615711252802 no 573 0.176610360912136 849 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_217 ketoconazole 989 nM 0.926669676990948 0.156587639224275 no 574 0.177049033003395 874 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1665 st014639 11.4 µM 0.926264476881354 0.156690943727046 no 575 0.177154275995429 924 981133 YIL048W NEO1 SGTC_738 1315-0003 72.4 µM 0.924501562243212 0.157140915335397 no 576 0.177612619239417 901 6251474 SGTC_2763 lisinopril 49.32 µM 0.92209924817825 0.157755455814187 no 577 0.178238404549868 850 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2318 6029776 164 µM 0.921386139783233 0.157938180850533 no 578 0.178424431229477 879 818325 SGTC_1779 st039427 55 µM 0.920988950122374 0.158040015927311 no 579 0.178528098051392 965 1124498 SGTC_1495 4469-0029 237 µM 0.919903117183786 0.158318631538736 no 580 0.178811694895222 962 793680 SGTC_505 gw-5074 63.9 µM 0.917323682714025 0.158981784076308 no 581 0.179486525423643 897 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1496 4469-0713 57.4 µM 0.916847364703607 0.159104440532758 no 582 0.17961131441686 878 746691 SGTC_2986 9022445 71.43 µM 0.916163568655081 0.159280632924292 no 583 0.17979055519423 903 6459286 SGTC_155 k072-0202 43.6 µM 0.913414583909337 0.159990247346016 no 584 0.180512269114102 886 5857737 SGTC_642 0335-0876 158 µM 0.913122623833795 0.160065734279578 no 585 0.180589026434379 901 6812350 SGTC_671 0560-0003 407 µM 0.912887773316443 0.16012647230655 no 586 0.180650784305534 869 3238678 SGTC_1696 st025591 34.7925 µM 0.911369027877709 0.160519620376805 no 587 0.18105048349779 899 2787147 SGTC_1817 st052116 64.4 µM 0.911053013006105 0.160601504346653 no 588 0.181133720998729 884 4361398 SGTC_1366 1683-0113 21.9 µM 0.910281343876176 0.16080156947999 no 589 0.181337077372884 893 708623 SGTC_1172 0370-0043 85 µM 0.90799483895016 0.161395330242511 no 590 0.181940474214178 908 376585 SGTC_536 3852-0578 10.6 µM 0.906989605338127 0.161656821721279 no 591 0.182206147056573 934 2869208 SGTC_2417 cerulenin 830 nM 0.904185094702012 0.162387818332315 no 592 0.182948631207603 884 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2114 5491910 81.25 µM 0.903945426157008 0.162450387647659 no 593 0.183012170047772 902 2849228 SGTC_329 k048-0121 21.3 µM 0.902456065409541 0.162839560780684 no 594 0.183407324985147 888 6832902 SGTC_1802 st050112 57.9 µM 0.901787455313771 0.16301446703622 no 595 0.183584892464458 937 4662563 SGTC_2291 7917025 104.35 µM 0.901691427467148 0.163039597638592 no 596 0.183610404049772 859 2964612 SGTC_3036 9090181 49.47 µM 0.898642193106911 0.163838895383402 no 597 0.184421638466436 895 25236586 SGTC_2810 7959871 45.46 µM 0.898299359939683 0.163928921231127 no 598 0.184512986845062 950 2974535 SGTC_614 0462-0418 107 µM 0.895569775385518 0.164646837963177 no 599 0.185241292121017 834 5188303 SGTC_1198 1612-1005 86.7 µM 0.893252516817458 0.165257903913055 no 600 0.185860979973281 935 6998509 SGTC_1893 st059353 36.1 µM 0.891721606347487 0.165662412293198 no 601 0.186271084793129 887 3112488 SGTC_183 3914-0051 30.55 µM 0.891216923476551 0.165795903504281 no 602 0.186406403527789 943 1596232 SGTC_369 0957-0393 4.5 µM 0.891060064753933 0.165837407603197 no 603 0.186448473872993 875 6997992 SGTC_3138 9097216 49.47 µM 0.891029959510423 0.165845374080739 no 604 0.186456548932348 998 25237486 SGTC_1638 st008370 60.6 µM 0.889397538362344 0.166277717234586 no 605 0.186894733734017 897 24207134 SGTC_849 0386-0493 241 µM 0.88789227169285 0.166677028278865 no 606 0.187299351127785 906 726119 SGTC_2654 protoveratrine a 100 µM 0.886693885280774 0.166995373438044 no 607 0.187621865669179 940 5702278 A heart drug and vasodilator. SGTC_2310 7668677 200 µM 0.886062960356888 0.167163132844652 no 608 0.18779180049481 901 2197143 SGTC_847 0342-0274 5.54 µM 0.885901782966002 0.167206006427786 no 609 0.187835227637373 968 18097 SGTC_396 dithiazanine 1.25 µM 0.884958099688972 0.167457170737349 no 610 0.188089615206432 894 10578 An antihelmenthic. SGTC_2320 7373003 200 µM 0.884533162849655 0.167570348363756 no 611 0.188204234322087 940 5415828 SGTC_503 tyrphostin 8 294 µM 0.884348310303764 0.167619597344224 no 612 0.188254108441354 917 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1203 3992-3522 103 µM 0.884172489382478 0.167666448741463 no 613 0.188301553350169 972 5322312 SGTC_2740 felodipine 17.08 µM 0.878737966764847 0.169118756420601 no 614 0.189771683912344 880 3333 L-type calcium channel blocker SGTC_1992 st073643 23.3 µM 0.876747582430027 0.169652676599129 no 615 0.190311877878619 923 3161292 SGTC_1447 4239-0816 81.9 µM 0.874850489259397 0.170162576728978 no 616 0.190827630657367 875 1341554 SGTC_1695 st026914 34.495 µM 0.874508943088759 0.170254481615036 no 617 0.190920576039535 931 3289191 SGTC_1980 st071811 45.7 µM 0.873825155885179 0.170438573910966 no 618 0.191106739332984 938 4974850 SGTC_1019 4262-0212 3.4 µM 0.871635875660639 0.171028838970245 no 619 0.191703526321646 1050 4677213 SGTC_3214 9129694 49.47 µM 0.871427436492278 0.171085105607503 no 620 0.191760405252727 904 17158655 SGTC_265 mycophenolic acid 32.932 µM 0.870184784444321 0.17142079614151 no 621 0.192099714841998 990 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_961 1252-1571 372 µM 0.869706674801768 0.171550064947968 no 622 0.192230361807058 956 6813498 SGTC_2560 caryophyllene 100 µM 0.868662367935727 0.171832635776932 no 623 0.192515915263011 1065 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_412 gemfibrozil 100 µM 0.868539090223826 0.171866012133153 no 624 0.192549641210087 925 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2324 6149169 200 µM 0.865720063241921 0.172630368413739 no 625 0.193321847396909 921 2888231 SGTC_2848 9016370 25.97 µM 0.864075306460811 0.173077330475096 no 626 0.193773261557649 985 7894410 SGTC_1770 st043884 66.3 µM 0.861841699693232 0.173685491436867 no 627 0.194387317273936 988 670149 SGTC_457 grayanotoxin iii 135 µM 0.861534293387943 0.173769297573807 no 628 0.194471921033647 977 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_570 0987-0065 62.6 µM 0.861359493967172 0.173816963447194 no 629 0.194520038981354 857 3104428 SGTC_991 3996-0057 64.7 µM 0.859676140380088 0.174276420986916 no 630 0.194983795302706 917 715343 SGTC_1730 st033808 45.1 µM 0.859510582608404 0.174321650266086 no 631 0.19502944200203 1016 1045166 SGTC_470 aa-861 153 µM 0.857403209868572 0.174898021988541 no 632 0.195611042975736 956 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3071 9117417 49.47 µM 0.855274617466558 0.175481423567595 no 633 0.196199567998312 890 45595590 YGL055W OLE1 SGTC_1618 st003135 44.5 µM 0.854651023210324 0.175652570742557 no 634 0.196372185932071 956 1270615 SGTC_1795 st049545 62.3 µM 0.854189547876349 0.175779292000042 no 635 0.196499986764728 973 5291882 SGTC_2771 fluoxetine 41.05 µM 0.852711571640024 0.176185534317193 no 636 0.196909636109134 931 3386 A selective serotonin reuptake inhibitor. SGTC_2379 9035213 200 µM 0.851798231820382 0.176436875293309 no 637 0.197163043962913 1017 646551 SGTC_2721 ifenprodil 61.44 µM 0.851213929458448 0.176597787723951 no 638 0.197325263202661 953 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1450 4112-4260 37.6 µM 0.847994013869347 0.177486192077421 no 639 0.19822065225209 998 1633175 SGTC_3189 9110682 49.47 µM 0.846902409406848 0.177788015005033 no 640 0.198524759702411 959 17122418 SGTC_482 fipronil 114 µM 0.845176734538534 0.178265815154474 no 641 0.199006085047139 972 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1415 3966-0071 78.1 µM 0.843608212826546 0.178700804512342 no 642 0.199444186706577 974 2893185 SGTC_296 1222-0039 74.9 µM 0.840416264413296 0.179588071456838 no 643 0.200337516511787 953 5984176 SGTC_1800 st050079 29.0735 µM 0.838074234444295 0.180240844099201 no 644 0.200994506280272 1039 3645560 SGTC_1185 1319-0113 81.3 µM 0.836829368836183 0.180588419470942 no 645 0.201344243315878 959 4672763 SGTC_1406 3909-7906 11.9 µM 0.836541748809339 0.180668784777572 no 646 0.201425100170256 1003 X1406 SGTC_2016 5121758 140 µM 0.835248891566245 0.181030305182432 no 647 0.201788793465811 1052 2795203 SGTC_3266 9136860 49.47 µM 0.835217980473539 0.181038954365393 no 648 0.201797493866904 964 4871271 YPR165W RHO1 SGTC_3202 9113761 49.47 µM 0.834582597909007 0.181216797090355 no 649 0.201976381792644 1038 4798415 SGTC_3097 9117246 49.47 µM 0.833974486469967 0.181387109101929 no 650 0.202147680570743 1040 16423892 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.83336184859072 0.181558790120802 no 651 0.202320342269467 1077 91467 include heat shock SGTC_1264 0783-0040 158 µM 0.832630516960399 0.181763866096372 no 652 0.202526571261505 938 2855798 SGTC_2502 avocadyne acetate 18.59 µM 0.831401631406112 0.182108789579104 no 653 0.202873388883866 1060 3952079 SGTC_3232 9132874 49.47 µM 0.830547893862702 0.182348657265879 no 654 0.203114540476221 969 3784940 SGTC_574 1315-0397 40 µM 0.827896363374671 0.183094894077951 no 655 0.203864597324159 1092 6794277 SGTC_855 0428-0020 25 µM 0.826541199560462 0.183477020904613 no 656 0.204248578530101 921 6812414 SGTC_1303 1160-0052 261 µM 0.824819735152649 0.183963152809996 no 657 0.204736970313153 1055 3562476 SGTC_746 1095-0025 46.6 µM 0.81896424652088 0.185622705967117 no 658 0.206403406339426 1024 6749286 SGTC_3183 9108214 49.47 µM 0.818730769880601 0.185689069552579 no 659 0.2064700185482 934 4974831 SGTC_1370 2001-0092 44.6 µM 0.817897367698213 0.185926076476133 no 660 0.20670789676231 1098 790957 SGTC_2867 9039098 71.43 µM 0.817769116709085 0.185962565756945 no 661 0.20674451787989 973 6463460 SGTC_3335 9143315 29.6265 µM 0.817695332976963 0.185983560319031 no 662 0.206765588017235 985 4899691 SGTC_3315 9136395 68.55 µM 0.814020242560553 0.187031136385579 no 663 0.20781667731111 1067 16876844 SGTC_2407 paclitaxel 400 µM 0.81251564909389 0.187461068347408 no 664 0.208247905365154 1026 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2718 lomofungin 53.02 µM 0.811618301664732 0.187717772562555 no 665 0.208505343176001 1004 5351222 A RNA synthesis inhibitor. SGTC_2205 7238770 200 µM 0.811170161111886 0.187846053407534 no 666 0.208633979352412 1038 279867 SGTC_2095 5432005 200 µM 0.811105903018917 0.187864451811068 no 667 0.208652428103743 974 783734 SGTC_3298 9116858 71.43 µM 0.808627715488196 0.18857485626774 no 668 0.209364658886484 1031 2506942 SGTC_3321 9137793 26.8275 µM 0.807974840326731 0.188762286667926 no 669 0.209552532960019 1051 4904192 SGTC_925 2064-1272 59.6 µM 0.805145164177207 0.189575969561151 no 670 0.210367957903891 952 6815817 SGTC_3125 9127534 49.47 µM 0.798949301923909 0.191365131209266 no 671 0.212159904844256 937 1639235 SGTC_2984 9022109 38.96 µM 0.798272569088661 0.19156117435721 no 672 0.212356166414463 1023 6459207 SGTC_3094 9117742 49.47 µM 0.798086709832067 0.191615037565557 no 673 0.212410086648129 1065 17149698 SGTC_3007 9078383 71.4286 µM 0.797231736243913 0.191862933880547 no 674 0.212658228834764 1037 6496995 SGTC_2881 9058953 51.95 µM 0.796269454473261 0.192142178513001 no 675 0.212937717854311 1079 17122249 SGTC_3193 9111931 49.47 µM 0.794801831767391 0.192568546592953 no 676 0.213364392648908 1060 17087244 SGTC_1757 st041620 31.8375 µM 0.79448684097794 0.192660131823883 no 677 0.213456033308314 1064 5289815 SGTC_1070 indatraline 8.81 µM 0.794367731626925 0.192694770429685 no 678 0.213490691915458 1024 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_213 1246-0773 967 nM 0.793825418178608 0.192852530598856 no 679 0.213648536503559 1041 6251622 SGTC_499 genistein 192 µM 0.793157632723049 0.193046899204616 no 680 0.213842994076847 1052 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_523 1934-0222 13.7 µM 0.792693637717373 0.193182022058656 no 681 0.213978169007264 1026 1361595 SGTC_3037 9091026 49.47 µM 0.791990792576619 0.19338681186489 no 682 0.214183022478745 1112 25236398 YIL048W NEO1 SGTC_2531 methyl deoxycholate 70.07 µM 0.791383085851288 0.193563987679723 no 683 0.214360238555761 1025 16667744 Haematoxylin. SGTC_1231 0242-0792 125 µM 0.789056663855692 0.194243166328749 no 684 0.215039444508209 1047 3707635 SGTC_1724 st037281 8.293 µM 0.788529514241659 0.194397264516256 no 685 0.215193520910722 1055 574124 YDL195W SEC31 SGTC_2381 9035592 200 µM 0.787230071736208 0.19477743973827 no 686 0.215573598253457 979 4749657 SGTC_2726 cimetidine 79.27 µM 0.787224324193859 0.194779122288884 no 687 0.215575280231458 1081 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_612 0302-0167 22.4 µM 0.786519438665831 0.194985539350717 no 688 0.215781617735663 1110 235821 SGTC_1037 k284-1091 78.7 µM 0.782312042203722 0.196220387669799 no 689 0.217015605728272 1021 3334711 SGTC_1189 1431-2119 7.28 µM 0.778727940554221 0.197276033380075 no 690 0.2180699967671 1090 3107275 SGTC_940 3232-1287 54.8 µM 0.778572273046522 0.197321960722952 no 691 0.218115858719233 1071 1585493 YIL048W NEO1 SGTC_1173 0443-0020 122 µM 0.778113359462992 0.197457393863656 no 692 0.21825109380157 1052 5331295 SGTC_2878 9043973 25.97 µM 0.777536605792143 0.197627683289704 no 693 0.218421123117914 1065 6465167 SGTC_448 monastrol 171 µM 0.776736377121908 0.197864101805347 no 694 0.218657160081392 1084 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2676 harmalol 100 µM 0.775020535798117 0.1983716033447 no 695 0.219163762512026 1083 5459187 A monoamine oxidase inhibitor SGTC_2242 6630449 61.2675 µM 0.775007879495288 0.198375349668078 no 696 0.219167501792829 975 691249 YDR170C SEC7 SGTC_757 1066-0008 322 µM 0.771989056707483 0.199270154122059 no 697 0.220060454485014 1085 6842497 SGTC_297 0986-0032 24 µM 0.771165900840491 0.199514565553112 no 698 0.220304301520278 1071 2847425 SGTC_2253 7938677 135.83 µM 0.770984241081719 0.199568528260494 no 699 0.220358136237677 1078 2301972 SGTC_1825 st052143 62.6 µM 0.768787408535893 0.20022180069549 no 700 0.221009762475896 1058 674173 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.768235845837847 0.200386020584592 no 701 0.221173540486936 1120 688751 SGTC_390 dec-rvkr-cmk 16.7 µM 0.766164721452222 0.201003390159561 no 702 0.221789148350622 1122 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1490 4089-0339 670 nM 0.765816861462604 0.201107193546587 no 703 0.221892639964962 1060 742542 SGTC_1875 nocodazole 6 µM 0.765144734580706 0.201307851057565 no 704 0.222092682129692 1094 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2432 5630864 12.22 µM 0.760203496048431 0.202786694934123 no 705 0.223566477787285 1061 5714970 SGTC_1075 aripiprazole 15.2 µM 0.756972850798078 0.203757081680362 no 706 0.22453306394423 1166 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3288 9119690 36.221 µM 0.756936988622663 0.203767869089648 no 707 0.224543806942536 1069 17595618 YKL019W RAM2 SGTC_2920 7982904 15.77 µM 0.754193285849605 0.204594189031994 no 708 0.225366584316041 1047 6456808 SGTC_1064 honokiol 6.76 µM 0.75173940185589 0.205334910664574 no 709 0.226103895145208 1102 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1854 st056233 32.9 µM 0.750912704486518 0.205584813184128 no 710 0.226352596979295 1065 5393174 SGTC_1578 josamycin 24.2 µM 0.750320015772722 0.205764088252859 no 711 0.226530995214358 1071 5282165 A P450 substrate. SGTC_678 1218-2179 85.9 µM 0.748426984048199 0.206337308978706 no 712 0.227101325698799 1098 6820081 YOR116C RPO31 SGTC_997 3996-0078 137 µM 0.747895345532787 0.206498462178429 no 713 0.227261642629589 1161 735687 SGTC_2184 6075246 200 µM 0.746384140999615 0.206956953851966 no 714 0.227717698280105 1090 2267320 SGTC_88 0180-0332 8.668 µM 0.745800330744917 0.20713424007177 no 715 0.227894020069059 1173 3101745 SGTC_963 1269-2853 151 µM 0.743314719682695 0.207890052800044 no 716 0.228645580940996 1103 3668223 SGTC_1429 4049-0205 9.46 µM 0.743167227102867 0.207934952764243 no 717 0.228690221184031 1172 22774478 SGTC_519 k048-0011 62.8 µM 0.742183341405972 0.208234615530836 no 718 0.228988130129709 1095 6836379 SGTC_2816 7982706 58.44 µM 0.741656124097119 0.20839529527837 no 719 0.22914785484931 1107 2981853 SGTC_2608 thymoquinone 42.66 µM 0.739764647942162 0.208972360978395 no 720 0.229721406674568 1062 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_819 1013-0258 27.7 µM 0.738816602926135 0.209261951399296 no 721 0.230009184321239 1152 5753198 SGTC_362 0310-0100 9.03 µM 0.738607215474068 0.209325942853442 no 722 0.230072770758496 1120 790235 SGTC_3038 9091290 49.47 µM 0.738452643520521 0.209373189385766 no 723 0.230119717225125 1129 25236843 SGTC_1 0258-0098 57.368 µM 0.738304986957985 0.209418328016551 no 724 0.230164568359586 1031 6790032 YDR047W HEM12 SGTC_426 0988-0037 14.6 µM 0.737835876384621 0.209561773169679 no 725 0.230307094580092 1160 5383008 SGTC_999 SEC7.066 22.7 µM 0.734824644765052 0.210483926174763 no 726 0.231223147941231 1156 740511 YDR170C SEC7 SGTC_2885 9057732 51.95 µM 0.732663338903312 0.211147265512297 no 727 0.231881894672481 1162 6471414 SGTC_743 1275-0778 158 µM 0.732324486531384 0.211251375704724 no 728 0.231985268553622 1136 2849257 YMR203W TOM40 SGTC_48 0382-0018 55 µM 0.731475386430956 0.211512388268009 no 729 0.232244416670382 1234 762596 SGTC_2160 5660466 132.927 µM 0.730797707764473 0.21172084147382 no 730 0.232451361940965 1098 2859134 SGTC_864 0469-0573 172 µM 0.730659294441202 0.211763432039738 no 731 0.232493642344285 1131 689425 SGTC_1866 st057638 64 µM 0.730376921635864 0.211850335301595 no 732 0.232579910567286 1121 688802 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.729897012815222 0.211998080247924 no 733 0.232726569190603 1134 6708514 SGTC_720 r052-1644 49.9 µM 0.729295746516342 0.212183271383102 no 734 0.232910386788567 1103 1422863 YOR257W CDC31 SGTC_2493 resveratrol 26.09 µM 0.728530058684849 0.212419241503551 no 735 0.233144587620068 1078 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1835 st008666 49.2 µM 0.727246233057302 0.212815235509457 no 736 0.233537564401184 1058 690455 SGTC_2875 9039966 71.43 µM 0.726754665607811 0.212966972731274 no 737 0.233688129538626 1181 6463691 SGTC_1806 st050005 60.3 µM 0.724690398040455 0.213604860412721 no 738 0.234320993532655 1133 5194765 SGTC_1167 k781-0610 148 µM 0.724535025290871 0.21365291778058 no 739 0.23436866612941 1156 4525169 SGTC_1127 asiatic acid 681.4 nM 0.72162168442629 0.214555190613594 no 740 0.235263551747859 1133 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_560 2332-1943 155 µM 0.721427567652748 0.214615387931002 no 741 0.235323245208446 1157 21177716 SGTC_2129 girgensonine 121.053 µM 0.720923231695382 0.214771832820678 no 742 0.235478374221228 1179 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1423 4048-0112 5.59 µM 0.719874273507723 0.21509743153219 no 743 0.235801204590174 1164 X1423 SGTC_1649 st011737 51.3 µM 0.719481832356719 0.215219319672721 no 744 0.235922046094579 1124 1761035 SGTC_2980 9014342 25.29 µM 0.718532509141629 0.215514335314236 no 745 0.23621450527956 1152 2996599 SGTC_2886 9058944 51.95 µM 0.718450135414149 0.215539945171537 no 746 0.236239891667471 1028 4949929 SGTC_3349 9149703 23.001 µM 0.718327724174253 0.215578005886062 no 747 0.236277619811215 1168 4910494 SGTC_1403 3909-7815 62.9 µM 0.715010452090597 0.216610911691007 no 748 0.237301292398458 1130 6615483 SGTC_2499 avocadenofuran 51.48 µM 0.713711976872386 0.217015998899615 no 749 0.23770264943877 1132 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1344 1488-0097 29.1 µM 0.712221593893203 0.217481495044759 no 750 0.238163783590239 1148 747966 SGTC_231 b-estradiol 524 µM 0.710485385090254 0.218024496902864 no 751 0.238701595386255 1133 450 A steroid. SGTC_3111 9122088 49.47 µM 0.710316581097545 0.218077332257294 no 752 0.238753919897273 1089 16876704 SGTC_2960 9079389 5.97 µM 0.708452981750435 0.218661125913444 no 753 0.239332000344161 1159 16457355 SGTC_355 1311-2252 105 µM 0.707982551014438 0.218808635760194 no 754 0.239478046687938 1161 5338538 SGTC_705 1124-0212 310 µM 0.70637300683196 0.21931376274286 no 755 0.239978101396096 1185 9554485 SGTC_2243 6634756 200 µM 0.706090831084017 0.219402387604526 no 756 0.24006582664861 1201 885676 SGTC_2690 usnic acid 100 µM 0.706040946893231 0.219418057212729 no 757 0.240081336898391 1226 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2514 salinomycin 42.74 µM 0.70387258967157 0.220099802153788 no 758 0.240756061402027 1226 23682228 A polyether potassium ionophore. SGTC_2796 7949634 45.45 µM 0.703682399821311 0.220159656924959 no 759 0.2408152916804 1166 2971588 SGTC_250 brefeldin a 552.239 µM 0.703143638725582 0.220329261447673 no 760 0.240983119531695 1089 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_234 nsc-17383 10.7 µM 0.702960550189387 0.220386915626812 no 761 0.241040167369895 1208 408974 SGTC_3091 9116372 49.47 µM 0.70120451611746 0.220940325956009 no 762 0.241587695936687 1205 17169793 SGTC_2756 carbadox 75.1 µM 0.699665713190301 0.221425929648794 no 763 0.24206804680606 1193 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2843 9000894 45.46 µM 0.699225413194564 0.221564988365193 no 764 0.242205585559117 1067 2242070 SGTC_1311 1190-0148 100 µM 0.693639437928351 0.2233335194612 no 765 0.243954177353825 1249 1961333 SGTC_2240 6690706 185.951 µM 0.693489929627474 0.223380964213875 no 766 0.244001071713085 1137 805876 SGTC_493 zm226600 134 µM 0.692007016681821 0.223851860146899 no 767 0.244466461280629 1229 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1412 3909-8563 178 µM 0.691432342438035 0.224034498333373 no 768 0.244646942504554 1260 23767530 SGTC_1587 estradiol valerate 56.1 µM 0.690607783135287 0.224296700719217 no 769 0.244906027494279 1213 13791 A steroid. SGTC_2382 9035899 200 µM 0.690345261507702 0.224380216766514 no 770 0.244988545458749 1241 6462679 SGTC_1355 1499-0035 1.68 µM 0.689216262945193 0.224739586371049 no 771 0.245343592034403 1217 1548538 SGTC_62 0180-0423 3.232 µM 0.688683262438878 0.22490935820831 no 772 0.245511305665292 1185 30102 YGL099W LSG1 SGTC_129 0088-0017 176.636 µM 0.687634415951481 0.225243649997969 no 773 0.245841514869096 1141 182446 SGTC_1784 st039334 36.3 µM 0.687475002353204 0.225294483447884 no 774 0.245891724045107 1253 3496984 SGTC_899 1083-0020 478 µM 0.687320910185962 0.225343626186377 no 775 0.245940262404619 1241 767123 SGTC_1424 4048-1941 275 µM 0.685588915676669 0.22589640746082 no 776 0.246486186608797 1257 X1424 SGTC_332 4112-0506 40.9 µM 0.684513677570641 0.226239964562792 no 777 0.246825427758907 1225 2790355 SGTC_2680 butyl paraben 22.24 µM 0.68447646621334 0.226251859515139 no 778 0.246837172537109 1241 7184 An antifungal and steroid mimetic. SGTC_2760 etidronate 98.04 µM 0.684168892484636 0.226350191812924 no 779 0.246934261483032 1218 3305 A chelator and antioxidant. SGTC_909 3448-9333 149 µM 0.683197067154659 0.226661046032008 no 780 0.247241162821857 1175 3344074 SGTC_1387 3342-1166 1.8 µM 0.682497449146278 0.226884979368039 no 781 0.247462227595219 1190 3418228 SGTC_1857 st056007 79.3 µM 0.682431149077861 0.226906207127878 no 782 0.247483182518831 1233 619834 SGTC_223 busulfan 5 mM 0.682161301596922 0.226992617653767 no 783 0.247568480800488 1203 2478 A DNA alkylator. SGTC_698 k064-0052 127 µM 0.679988040844977 0.227689215081753 no 784 0.248256016652628 1262 5088751 SGTC_347 4534-1311 26.2 µM 0.679541936451533 0.227832354082034 no 785 0.248397272707165 1237 2862016 SGTC_1012 4112-3522 18 µM 0.678601630828394 0.22813423043406 no 786 0.248695154624283 1226 3112398 SGTC_2223 6903751 107.57 µM 0.678453434017083 0.228181828146614 no 787 0.248742119634298 1189 5598863 SGTC_2402 5553605 200 µM 0.678435736074725 0.228187512728281 no 788 0.248747728599918 1257 6758546 SGTC_2140 5586273 200 µM 0.678238487707422 0.228250874321125 no 789 0.248810246600815 1214 854421 SGTC_1583 clindamycin 39.6 µM 0.677024353479754 0.22864110530326 no 790 0.249195251398006 1154 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1668 st014914 51.6 µM 0.676310149200578 0.228870830311501 no 791 0.249421875158005 1227 2839556 SGTC_2252 omeprazole 400 µM 0.674884225154712 0.229329868457184 no 792 0.249874661777955 1179 4594 A proton pump inhibitor. SGTC_485 niflumic acid 177 µM 0.674406092030314 0.229483906111033 no 793 0.250026585355217 1239 4488 A COX2 inhibitor. SGTC_1619 st003326 88.7 µM 0.672815913600982 0.229996622444233 no 794 0.250532206178011 1205 2849032 SGTC_132 0417-1715 25.805 µM 0.672697364939749 0.230034871385165 no 795 0.250569922171623 1261 6769098 SGTC_718 1130-0073 349 µM 0.672246649888157 0.230180324101243 no 796 0.250713343619957 1295 6740020 SGTC_530 4358-1714 28 µM 0.672104879896401 0.230226086103666 no 797 0.250758465050179 1244 1564641 SGTC_2000 st075254 36.4 µM 0.671145201207161 0.23053599501625 no 798 0.251064017019935 1215 17234175 SGTC_1907 st060210 83.7 µM 0.66876763000749 0.231304787183974 no 799 0.251821859291383 1260 688793 SGTC_2464 5717415 7.67 µM 0.668542668483998 0.23137760290144 no 800 0.251893627456302 1170 5285744 SGTC_3289 9119912 71.43 µM 0.665053152200752 0.232508727845836 no 801 0.253008248620597 1261 17014829 SGTC_2746 daunorubicin 9.88 µM 0.664808859909136 0.232588030070835 no 802 0.253086377539506 1136 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1138 3761-0006 1.03 µM 0.664571121405705 0.23266521923886 no 803 0.253162422626795 1228 12061087 SGTC_2744 captopril 92.04 µM 0.660450422943617 0.2340053915776 no 804 0.254482411737146 1238 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2720 fluspirilene 36.88 µM 0.659918019337127 0.234178856274253 no 805 0.25465322001028 1236 3396 An atypical antipsychotic. SGTC_1861 st057647 17.4 µM 0.659017546060596 0.234472405295797 no 806 0.254942250752643 1307 688668 SGTC_621 3584-0052 32.1 µM 0.658392213295169 0.234676379838324 no 807 0.255143068814056 1266 2273927 SGTC_3258 9138477 49.47 µM 0.654870331914187 0.235826997324243 no 808 0.256275621601578 1301 4970355 SGTC_1643 st009866 20.2 µM 0.653760095965945 0.236190361065519 no 809 0.256633189430551 1260 3156273 YOR207C RET1 SGTC_918 glabranin 770.725 nM 0.651925913816668 0.236791336607077 no 810 0.257224483431806 1292 124049 Also referred to as licorice root. SGTC_2614 arthonioic acid 13.39 µM 0.650788121691842 0.237164559970066 no 811 0.257591634496705 1217 6710684 SGTC_2451 5856223 45.7 µM 0.647428177928086 0.238268586832051 no 812 0.258677431992741 1252 2179896 SGTC_2967 9089538 49.85 µM 0.647166140666492 0.238354806507783 no 813 0.258762211289618 1304 728216 SGTC_2009 4012297 12.05 µM 0.644068463033168 0.23937534756447 no 814 0.259765519814348 1267 45595307 SGTC_3225 9130819 49.47 µM 0.643552102671485 0.239545696115425 no 815 0.25993295905067 1288 4547121 SGTC_3222 9128301 49.47 µM 0.642252897462966 0.239974599699614 no 816 0.260354496065987 1301 4911358 SGTC_1401 3807-4679 7.6 µM 0.641436899821843 0.240244197057639 no 817 0.260619432646282 1284 3291456 SGTC_200 k038-0079 37.545 µM 0.640505244475423 0.240552208233964 no 818 0.260922090337261 1259 3436683 SGTC_1041 0206-0046 107 µM 0.63970031371808 0.240818496491412 no 819 0.26118372573554 1302 50494 SGTC_2662 daunorubicin 22.37 µM 0.635422347951485 0.242236426376977 no 820 0.262576498280777 1250 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_809 3998-0021 90 µM 0.635004951614478 0.242375014101969 no 821 0.262712592779895 1237 715485 SGTC_1675 st018485 24.5 µM 0.634484632860325 0.242547835202491 no 822 0.262882296246004 1315 3323024 SGTC_1799 st045822 46.1415 µM 0.634301476330965 0.242608685544147 no 823 0.262942046612884 1261 3674992 SGTC_1275 0867-0008 21.1 µM 0.634109858100133 0.242672355975363 no 824 0.263004564834693 1290 3422836 SGTC_2472 5377652 49.4 µM 0.633382030988922 0.242914278983004 no 825 0.263242098183078 1281 1610903 SGTC_2529 gangaleoidin 93.61 µM 0.632569868919506 0.243184388119258 no 826 0.263507284347563 1343 4565183 SGTC_1087 pterostilbene 9.05 µM 0.631630926601872 0.24349686414653 no 827 0.263814036480242 1355 5281727 Similar to reservatol, lowers cholesterol. SGTC_3341 9147222 25.867 µM 0.63127230066879 0.243616270554546 no 828 0.263931247484945 1280 1939759 SGTC_2679 rapamycin 1 nM 0.630146277169965 0.24399139147436 no 829 0.264299442234596 1271 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1954 st077032 68.9 µM 0.629761343238489 0.244119698925048 no 830 0.264425370481356 1217 698907 SGTC_370 0180-0345 38.7 µM 0.629163613011182 0.244319008438378 no 831 0.264620973947767 1258 3989527 SGTC_2287 7945887 168.79 µM 0.628133194760123 0.244662800964326 no 832 0.264958344571581 1319 1245853 SGTC_349 k015-0014 24 µM 0.626846052409091 0.245092613538742 no 833 0.265380076393708 1274 2196908 SGTC_2853 9015042 58.44 µM 0.625961636763326 0.245388179714476 no 834 0.26567005225958 1233 6457456 SGTC_2544 sphondin 68.51 µM 0.625896325958794 0.245410013769348 no 835 0.265691472266848 1334 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1968 st069590 43.6 µM 0.624767266027077 0.245787634767183 no 836 0.266061908808897 1251 6384066 SGTC_3220 9131269 49.47 µM 0.624632062598638 0.245832875284648 no 837 0.266106285624085 1336 17722206 SGTC_2442 5158906 48.48 µM 0.622129316883281 0.246671127423317 no 838 0.266928419509462 1363 1893835 SGTC_2297 7971671 152.32 µM 0.621816820587229 0.246775900138446 no 839 0.267031162314982 1356 909016 SGTC_3277 9138724 49.47 µM 0.621764809061596 0.246793340701639 no 840 0.267048264648185 1271 15943418 SGTC_1934 st074720 32.6 µM 0.618373391709331 0.247931977540746 no 841 0.268164616684807 1299 17250992 SGTC_625 k213-0058 121 µM 0.615179432883229 0.249006877693372 no 842 0.269218114405548 1378 3655420 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.615020635738958 0.249060384177002 no 843 0.269270546296152 1298 17037758 SGTC_3179 9107801 49.47 µM 0.61319789360664 0.249674992499203 no 844 0.269872748694322 1312 4818259 SGTC_1548 st061468 90.8 µM 0.612043259685149 0.250064738531236 no 845 0.27025456822655 1315 390799 SGTC_101 0490-5701 117.494 µM 0.611411357221877 0.25027817343506 no 846 0.270463642875123 1232 4661669 SGTC_361 000s-0510 1.45 µM 0.610818697159029 0.250478441351598 no 847 0.270659806994809 1327 660 SGTC_1607 st000305 50.6 µM 0.609961815983718 0.250768143266223 no 848 0.270943551037035 1371 5457690 SGTC_1948 st076329 66.6 µM 0.608059435522709 0.251411950407203 no 849 0.271574027394083 1250 24208413 SGTC_930 2810-3379 265 µM 0.608036885930965 0.251419586917571 no 850 0.271581505033418 1463 1015764 SGTC_2800 7887935 81.82 µM 0.607931959475463 0.251455122298099 no 851 0.271616300900521 1343 2961002 SGTC_547 1120-0019 610 nM 0.607272154674472 0.251678638808949 no 852 0.271835157202843 1338 3676939 SGTC_2350 9023895 38.85 µM 0.607155236712177 0.25171825706321 no 853 0.271873947872394 1378 2997209 SGTC_2981 9013952 38.96 µM 0.606801559747765 0.251838122372812 no 854 0.271991306453324 1232 2996344 SGTC_1764 st044502 93.5 µM 0.605452290382464 0.25229568233777 no 855 0.272439257971499 1303 8407 SGTC_1569 carminic acid 40.6 µM 0.605154518450936 0.252396720820454 no 856 0.272538166277784 1347 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.605071482769346 0.252424899875068 no 857 0.272565750694705 1291 4620898 SGTC_1244 0416-0015 52.5 µM 0.6050309938258 0.252438640836333 no 858 0.272579201606621 1357 96201 SGTC_247 mechlorethamine 29.705 µM 0.604982262924936 0.252455179439894 no 859 0.272595391032411 1261 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2830 7992007 71.43 µM 0.604156527432218 0.25273550960294 no 860 0.272869790201427 1332 1952075 SGTC_1765 st044815 90.4 µM 0.60396136552231 0.252801789348696 no 861 0.272934664230915 1283 645695 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.603817706111003 0.252850583963966 no 862 0.272982423132937 1339 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2985 9022375 71.43 µM 0.601674911961639 0.253578982450961 no 863 0.273695276485115 1349 4939335 SGTC_1379 2144-0755 36.5 µM 0.600863325640638 0.253855151942184 no 864 0.273965510937969 1366 5392327 SGTC_2421 5690543 90.72 µM 0.600603639803494 0.253943552094591 no 865 0.274052006550295 1370 3397993 SGTC_1727 st034309 9.9045 µM 0.600408920591929 0.254009847430058 no 866 0.274116872066794 1445 870305 SGTC_2656 pseudo-anisatin 100 µM 0.600396718014889 0.25401400229903 no 867 0.274120937282705 1340 6708809 A neurotoxin. SGTC_522 1273-0010 11.6 µM 0.597066127325185 0.255149370520549 no 868 0.275231615887946 1390 5705015 SGTC_1276 0871-0068 94.2 µM 0.596765983592195 0.255251817006223 no 869 0.275331815923715 1358 3414906 SGTC_779 1360-0071 233 µM 0.595590838485177 0.255653129959336 no 870 0.275724299226287 1467 7566 SGTC_2477 5967686 25.23 µM 0.595364907277238 0.255730323386158 no 871 0.275799788840007 1317 776118 SGTC_2677 mitomycin C 100 µM 0.595330580801165 0.255742052703773 no 872 0.275811259115532 1351 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1509 1326-1131 80 µM 0.593442104115905 0.25638777554784 no 873 0.276442659133816 1319 768313 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.592145499003872 0.256831612420144 no 874 0.276876580724502 1366 5379071 SGTC_599 1935-0052 86.5 µM 0.591174164675274 0.25716436866009 no 875 0.277201865647906 1330 9557311 SGTC_1776 st049249 45.9 µM 0.591107427893834 0.257187239335062 no 876 0.277224221631175 1321 1822314 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.58848077331989 0.258088232256677 no 877 0.278104817700001 1363 5106787 A p450 inhibitor. SGTC_695 3505-6186 243 µM 0.588374202874115 0.25812482248584 no 878 0.278140574635177 1375 1819379 SGTC_312 4092-0653 6.84 µM 0.586331450517643 0.258826707012229 no 879 0.278826400019305 1401 1148278 SGTC_2164 5685496 200 µM 0.584706888142158 0.259385606704039 no 880 0.279372410841709 1352 759046 SGTC_588 3970-1144 52.9 µM 0.584135384053083 0.259582369924622 no 881 0.279564615179201 1336 1888707 SGTC_2941 9056145 11.23 µM 0.583839051621433 0.259684424588605 no 882 0.279664300938686 1266 2119517 SGTC_380 3970-0968 6 µM 0.583523634418572 0.259793074653366 no 883 0.279770425734966 1321 2891601 SGTC_1217 1183-1422 255 µM 0.583091261921021 0.259942049784431 no 884 0.279915932874107 1407 2849664 SGTC_966 1300-0360 30.2 µM 0.581811081191443 0.26038339778758 no 885 0.280346969592509 1366 70588 SGTC_3320 9137005 35.139 µM 0.579228494685717 0.26127492930886 no 886 0.281217503201915 1363 4908713 SGTC_1811 st050069 61.5 µM 0.578713573796271 0.261452871845141 no 887 0.281391227753209 1365 3877702 SGTC_3 0833-0587 95.581 µM 0.577632876048837 0.261826533595194 no 888 0.281756003024671 1296 5382644 SGTC_158 k038-0087 26.446 µM 0.576616192700835 0.262178311631789 no 889 0.282099379026722 1351 X158 SGTC_1976 st070609 63.5 µM 0.576046165318445 0.262375650143973 no 890 0.282291988954236 1331 682556 SGTC_2024 5144227 134 µM 0.573779268393324 0.263161182113963 no 891 0.283058589748779 1395 3475211 SGTC_2824 7998404 51.95 µM 0.573108429711464 0.263393873340237 no 892 0.283285639968157 1388 837851 SGTC_310 1273-0058 1.06 µM 0.571681010217943 0.263889346145857 no 893 0.283769050906091 1371 2734232 SGTC_321 4534-3890 65.3 µM 0.571569886246882 0.263927938407769 no 894 0.283806700797665 1405 699746 SGTC_3060 1327-0027 12.5 µM 0.571255730005301 0.264037057340499 no 895 0.283913152950196 1321 16000455 YPR107C YTH1 SGTC_3004 9076122 71.4286 µM 0.570853410956821 0.264176832278407 no 896 0.284049507056916 1415 44782551 SGTC_2115 tiliquinol 12.7705 µM 0.569983580270231 0.264479160340481 no 897 0.284344417401962 1406 71208 A bioactive hydroxyquinoline. SGTC_1901 st060216 58.6 µM 0.569422247159066 0.264674356973531 no 898 0.2845348113361 1368 688792 SGTC_2128 5255449 168.493 µM 0.567434021976876 0.265366326497265 no 899 0.285209670305447 1355 736008 SGTC_2234 tolnaftate 200 µM 0.566994295361375 0.265519490109157 no 900 0.285359028694847 1375 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_576 1073-0113 22.7 µM 0.565819773115611 0.265928814205689 no 901 0.285758151721996 1496 5439563 SGTC_2854 9024559 71.43 µM 0.565806187551843 0.265933550680221 no 902 0.285762769885166 1344 3163529 SGTC_1834 st055981 52.8 µM 0.565675392442131 0.265979153308276 no 903 0.2858072330992 1456 471719 YDL150W RPC53 SGTC_602 3130-1533 38.1 µM 0.563935348678071 0.266586208392313 no 904 0.286399066022696 1450 720941 SGTC_3275 9138069 49.47 µM 0.563790896494232 0.266636635401931 no 905 0.286448224003053 1415 17617007 SGTC_2571 chrysanthemic acid 100 µM 0.562746531163565 0.267001357733579 no 906 0.286803747113208 1335 2743 An insecticide. SGTC_1488 4013-0813 75.9 µM 0.561444517433776 0.2674564108635 no 907 0.287247271637385 1372 2910057 SGTC_1588 farnesol 29.9 µM 0.55997447440519 0.267970659828741 no 908 0.287748424307858 1392 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_965 1291-5240 308 µM 0.55988865715205 0.268000695707191 no 909 0.287777693042207 1454 2834598 SGTC_2445 5742597 35.57 µM 0.559459159251328 0.268151044637178 no 910 0.287924198234989 1361 1774255 SGTC_2139 5578692 56.4705 µM 0.554432327225975 0.26991387423931 no 911 0.289641503626816 1398 650991 YMR113W FOL3 SGTC_3280 9140961 49.47 µM 0.55279547877205 0.270489140205631 no 912 0.290201732392339 1396 4901226 SGTC_2861 9024595 19.48 µM 0.55239982207316 0.270628284563408 no 913 0.290337226248039 1368 16482810 SGTC_3131 9127911 49.47 µM 0.55113541109188 0.271073191542777 no 914 0.290770426169741 1450 45595681 SGTC_2367 9070478 135.38 µM 0.548987585029067 0.27182978006159 no 915 0.291506984905762 1432 572802 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.54735010458924 0.272407300397111 no 916 0.292069113629649 1420 97141 SGTC_808 0711-0032 135 µM 0.545102169471813 0.273201112290467 no 917 0.292841625342497 1435 4252555 SGTC_441 propafenone 146 µM 0.544480072035099 0.273420995460235 no 918 0.293055579014146 1379 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3241 9133421 49.47 µM 0.544227771891263 0.273510197061255 no 919 0.293142371521272 1430 17018221 SGTC_2709 st078560 56 µM 0.543399735104802 0.273803053547358 no 920 0.293427304026631 1523 17250903 SGTC_2222 6885208 172.143 µM 0.542970095214651 0.273955067813275 no 921 0.293575196270763 1397 609514 SGTC_2015 5119600 184 µM 0.542170518683773 0.274238083281544 no 922 0.293850521329152 1507 2828786 SGTC_2299 7976368 114.88 µM 0.541478813131795 0.27448303352012 no 923 0.294088798559831 1515 2979718 SGTC_71 0417-1750 47.813 µM 0.541412860782134 0.274506394533477 no 924 0.294111522344891 1553 6811472 SGTC_2762 leflunomide 42.06 µM 0.54134169362694 0.27453160378601 no 925 0.294136043793722 1450 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_607 4491-0986 66.8 µM 0.541167283873541 0.274593389074356 no 926 0.294196142642753 1495 698981 YDR232W HEM1 SGTC_1688 st021091 57.6 µM 0.540453366593963 0.274846368343065 no 927 0.29444220639271 1458 3656366 SGTC_1030 k029-0042 36.7 µM 0.539495381609404 0.275186014317512 no 928 0.294772541422577 1463 6080581 SGTC_316 k060-0003 58.6 µM 0.539113081164096 0.27532161357339 no 929 0.294904415003183 1455 6152314 SGTC_1156 4092-0367 4.88 µM 0.537017393016829 0.276065522976759 no 930 0.295627799932928 1429 1357585 SGTC_2962 9082311 13.18 µM 0.536092709527196 0.276394072691465 no 931 0.295947239237424 1381 16459453 SGTC_3006 9075424 71.4286 µM 0.535704068285274 0.276532218207752 no 932 0.296081545748173 1383 7465181 SGTC_780 0109-0199 192 µM 0.535288858280855 0.276679845185947 no 933 0.296225064780744 1551 610414 SGTC_1787 fluconazole 80 µM 0.535056055129432 0.276762634713648 no 934 0.296305548099198 1356 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_118 0083-0097 135.343 µM 0.533856972414476 0.277189245005003 no 935 0.296720246570392 1474 5207356 SGTC_2198 6589944 200 µM 0.532629579860128 0.277626260313157 no 936 0.297145010922634 1428 5290268 SGTC_1241 0364-0022 50.8 µM 0.530533404813072 0.278373384594283 no 937 0.29787107730813 1504 4563895 SGTC_3052 9092717 49.47 µM 0.530220515521902 0.278484989419549 no 938 0.297979524249048 1420 25237534 SGTC_3195 9113082 49.47 µM 0.529573092334004 0.278715988703945 no 939 0.2982039772422 1436 17018038 SGTC_1791 st048313 56.1 µM 0.52935176048046 0.278794980852064 no 940 0.298280727704494 1483 1204976 SGTC_1763 st044482 94.5 µM 0.528957296922338 0.27893578978294 no 941 0.298417536728186 1476 88505 SGTC_1133 3473-0247 50 µM 0.528529502811374 0.279088535585968 no 942 0.29856593782187 1388 711311 SGTC_2809 7964133 12.99 µM 0.528481700717286 0.279105606063611 no 943 0.29858252237668 1469 1253665 SGTC_300 r073-0011 5.04 µM 0.527830697579865 0.279338134569548 no 944 0.29880842441133 1469 2735780 SGTC_917 harmaline 728.087 nM 0.525947516889806 0.280011307760854 no 945 0.299462336405591 1484 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1022 4477-0945 21.3 µM 0.525800058195754 0.280064052423675 no 946 0.299513567053358 1423 4648966 SGTC_1822 st052468 42 µM 0.52279441802665 0.28114019130381 no 947 0.300558662248242 1398 2873678 SGTC_1147 3809-1045 12.3 µM 0.52229461862548 0.281319332875742 no 948 0.300732607724049 1408 325925 SGTC_1646 st011709 75.6 µM 0.521606236041137 0.281566157914592 no 949 0.300972260256635 1487 5757843 SGTC_3073 9114972 49.47 µM 0.520828337138014 0.281845205388063 no 950 0.301243180450432 1504 41905075 SGTC_1738 st035555 74 µM 0.520770699977956 0.281865886260596 no 951 0.301263258213688 1455 5331140 SGTC_1539 benzyladenosine 56 µM 0.519826586244118 0.282204749114241 no 952 0.301592223667075 1422 92208 A nucleotide analog. SGTC_713 1488-1073 324 µM 0.515629991502442 0.283713366013072 no 953 0.30305642958471 1453 3312542 SGTC_3250 9135583 49.47 µM 0.515072241229683 0.28391415981427 no 954 0.303251269718002 1520 7699353 SGTC_2825 7998094 58.44 µM 0.513690115915733 0.284412026983336 no 955 0.303734331754732 1473 2987815 SGTC_1927 st060202 13.8 µM 0.513215192268911 0.284583199532772 no 956 0.303900399978995 1469 688887 SGTC_207 4185-0010 4.486 µM 0.511324267255007 0.285265216413588 no 957 0.304562007580064 1515 3761753 SGTC_1998 st075797 76.8 µM 0.510407904015555 0.285596009257023 no 958 0.304882860298864 1465 24208315 SGTC_2988 9073640 71.4286 µM 0.509825798359382 0.285806235093546 no 959 0.305086755027895 1510 9102229 SGTC_70 0141-0289 43.283 µM 0.509401719184299 0.28595943642875 no 960 0.305235335771903 1572 352408 SGTC_1439 4092-1168 46 µM 0.508839714652253 0.286162524309341 no 961 0.305432289618262 1490 2886240 SGTC_1721 st082152 9.2685 µM 0.508211793211436 0.286389513152487 no 962 0.305652410596834 1415 5296051 SGTC_3061 glucosamine 200 µM 0.50806182446206 0.286443738359036 no 963 0.305704993282344 1478 91431 and experimental redox chemotherapeutic SGTC_2832 7992762 51.95 µM 0.506908840491702 0.286860793143047 no 964 0.306109391209721 1331 2985177 SGTC_1794 st048918 76.9 µM 0.506848369187515 0.286882674627367 no 965 0.306130607460797 1454 672303 SGTC_110 0850-0284 111.64 µM 0.506733174018733 0.286924360078619 no 966 0.306171025283068 1362 3906265 SGTC_2093 5331342 194.4 µM 0.505787958371474 0.287266511755789 no 967 0.306502756368906 1524 33839 SGTC_649 1123-0311 367 µM 0.505589731583402 0.28733829090118 no 968 0.30657234579495 1448 693629 YIL048W NEO1 SGTC_526 4469-0568 170 µM 0.505492184320292 0.28737361648321 no 969 0.306606593263355 1450 2901964 SGTC_1334 1486-0610 236 µM 0.502848368212129 0.288331824569806 no 970 0.307535442150543 1496 3742339 SGTC_3249 9135183 49.47 µM 0.501822037190203 0.288704207033516 no 971 0.307896355071553 1502 4902779 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.49875358606487 0.289818878128225 no 972 0.308976494507647 1438 2333 A French combination drug. SGTC_2747 doxorubicin 7.63 µM 0.495650000968624 0.290948361803532 no 973 0.310070684415036 1445 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2711 st079103 59.1 µM 0.493959288864547 0.29156452469466 no 974 0.31066746567114 1582 54693780 SGTC_2522 biochanin a 4.94 µM 0.493564136479261 0.291708621652442 no 975 0.310807017019685 1533 5280373 A possible chelator. SGTC_980 1473-0395 201 µM 0.492551974248631 0.292077869804764 no 976 0.311164594638972 1456 768876 SGTC_2752 diclazuril 33.15 µM 0.49250743326244 0.292094123853213 no 977 0.311180334218286 1523 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2146 5545642 200 µM 0.491886565237943 0.292320736950514 no 978 0.311399768118678 1481 825326 SGTC_894 0960-0238 55.9 µM 0.490828979454515 0.292706937549683 no 979 0.31177370582688 1508 6741907 YDL195W SEC31 SGTC_1525 8-methoxypsoralen 92.5 µM 0.489839248167928 0.293068574101142 no 980 0.312123827643987 1665 4114 Related to psoralen; DNA damaging agent. SGTC_2994 9053520 71.4286 µM 0.489749442763143 0.293101398227397 no 981 0.312155605108534 1596 4647384 SGTC_1451 4152-0210 104 µM 0.488025524627298 0.293731825372715 no 982 0.312765880826549 1601 659563 SGTC_3168 9103419 49.47 µM 0.487979356238027 0.293748717516787 no 983 0.312782231737718 1488 16649256 SGTC_3046 9092212 49.47 µM 0.487441410908908 0.293945574706141 no 984 0.312972776603879 1530 25236637 SGTC_908 3448-7491 47.7 µM 0.487090082818459 0.294074173593285 no 985 0.313097247015045 1489 1203031 SGTC_2525 harmine 47.85 µM 0.486501253243101 0.294289764976007 no 986 0.313305908498115 1570 5280953 A monoamine oxidase inhibitor SGTC_2667 digitoxin 100 µM 0.48519497896619 0.294768298708558 no 987 0.313769021698398 1517 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3181 9108277 49.47 µM 0.480367477944657 0.296539885485624 no 988 0.315483057678322 1457 17097298 SGTC_1855 st056195 39.6 µM 0.48020534245108 0.296599470233577 no 989 0.315540694193667 1589 4028379 SGTC_2256 7954252 200 µM 0.479934359781302 0.296699068528948 no 990 0.315637034116782 1480 2972920 SGTC_3039 9090270 49.47 µM 0.479218611210582 0.296962211877468 no 991 0.315891557724973 1570 17173750 SGTC_2130 NSC 7 2.4545 µM 0.478537261596012 0.297212807675599 no 992 0.316133930024408 1608 21448 SGTC_1963 st076565 50.3 µM 0.478111385294823 0.297369491181851 no 993 0.316285464523087 1509 4914280 SGTC_514 4466-0038 2.65 nM 0.477115654660459 0.297735976096981 no 994 0.316639883892471 1553 5722064 SGTC_423 5-fluorouracil 457 µM 0.476134819712453 0.298097179879714 no 995 0.316989165964177 1433 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1709 st033179 39.1045 µM 0.475469406765893 0.298342339481247 no 996 0.317226216997218 1498 573381 SGTC_784 4579-0127 173 µM 0.473369863316592 0.299116480011472 no 997 0.317974663347058 1650 1948547 SGTC_1955 wogonin 32.4 µM 0.473205769263353 0.299177022925761 no 998 0.318033191070454 1603 5281703 A flavanone. SGTC_1142 3253-1408 9.78 µM 0.473199096190157 0.299179485090599 no 999 0.318035571263744 1514 256655 SGTC_1221 2958-7315 257 µM 0.472002117774387 0.299621283078221 no 1000 0.318462638484727 1521 4562705 SGTC_3154 9100113 49.47 µM 0.471110113190105 0.299950709039728 no 1001 0.318781051753978 1474 25237525 SGTC_684 1140-0066 328 µM 0.470618335124455 0.300132397524415 no 1002 0.318956655924106 1500 6813534 SGTC_1224 0823-0416 294 µM 0.469881469524165 0.300404727254038 no 1003 0.319219852049682 1594 3598164 SGTC_422 cantharidin 155 µM 0.469276733165645 0.30062830821986 no 1004 0.319435921909553 1465 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_288 1315-0019 35.1 µM 0.467633035162872 0.301236389593031 no 1005 0.320023518270858 1530 6811474 SGTC_2415 st077333 57.7 µM 0.467360331533806 0.301337329078543 no 1006 0.320121049291474 1766 2766255 SGTC_2356 9061756 188.97 µM 0.467262424360252 0.301373572500859 no 1007 0.320156068310886 1573 20104043 SGTC_2197 6588183 93.1375 µM 0.466852380844496 0.301525384331647 no 1008 0.320302748325482 1515 884136 SGTC_2108 5365811 200 µM 0.464941895105115 0.302233163247159 no 1009 0.320986533693312 1588 780283 SGTC_3345 9148410 3.559 µM 0.463812477194565 0.302651929789289 no 1010 0.321391051596343 1632 4903596 SGTC_3279 9140807 49.47 µM 0.462880381178374 0.302997728836322 no 1011 0.321725055377149 1527 45595718 SGTC_171 k064-0041 9.68 µM 0.461078448153836 0.303666730149171 no 1012 0.322371161741403 1473 53325 SGTC_1348 1493-0373 93.8 µM 0.461050072882333 0.303677270270451 no 1013 0.32238134036082 1571 3010129 SGTC_983 1491-0821 12.2 µM 0.460786391498786 0.30377522370572 no 1014 0.322475933046049 1612 46495113 SGTC_874 0599-0792 117 µM 0.458676466251198 0.304559534500743 no 1015 0.323233258150354 1671 765305 SGTC_1261 0712-0010 12.7 µM 0.458457125654832 0.304641120432228 no 1016 0.323312029194423 1642 2840123 SGTC_2190 6049624 200 µM 0.458040015811131 0.304796295426285 no 1017 0.323461846289819 1557 2265554 SGTC_135 0933-0004 26.348 µM 0.456149072161637 0.305500212597135 no 1018 0.324141392275297 1490 21230617 YGL099W LSG1 SGTC_3114 9122766 49.47 µM 0.456042971805194 0.305539730551254 no 1019 0.324179538816133 1480 17176985 SGTC_1386 3228-0095 33.8 µM 0.45280391335685 0.306747233168718 no 1020 0.325344972726058 1638 870181 SGTC_947 3447-0010 211 µM 0.45265495475072 0.306802814701886 no 1021 0.325398610199328 1524 748350 SGTC_2067 5224629 34.075 µM 0.449788390107967 0.307873291705207 no 1022 0.326431514991455 1518 2835000 SGTC_3096 9117468 49.47 µM 0.449782387256366 0.307875535103949 no 1023 0.326433679390276 1500 41316311 SGTC_453 enantio-paf c16 10 µM 0.448724998410348 0.308270816741468 no 1024 0.326815024507497 1548 13871343 A lipid and platelet activating factor SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.448628483175339 0.308306907930488 no 1025 0.326849841547745 1522 16486 A toxic proline analog. SGTC_3177 9107506 49.47 µM 0.44764451869678 0.308674960177466 no 1026 0.327204884249969 1614 8897194 SGTC_2906 7926292 26.41 µM 0.446461099632884 0.309117873167532 no 1027 0.327632103074912 1526 2966319 SGTC_3342 9147791 14.508 µM 0.444289021052595 0.309931529397103 no 1028 0.328416818939397 1535 1838168 SGTC_2119 5528445 120.635 µM 0.444165530309294 0.309977816810329 no 1029 0.328461455743832 1615 791935 SGTC_581 0958-0271 211 µM 0.443127080123734 0.31036717296156 no 1030 0.328836909414466 1508 4591145 SGTC_2909 7941780 10.49 µM 0.442714661416057 0.310521864099897 no 1031 0.328986068157196 1654 1243215 SGTC_2389 9091542 195.52 µM 0.442442616515884 0.310623921792752 no 1032 0.329084473063666 1541 3626624 YOL127W RPL25 SGTC_1832 st054113 55 µM 0.441085605382086 0.311133222334896 no 1033 0.329575512039272 1585 1251267 SGTC_317 4495-0002 170 µM 0.440557878012185 0.311331381741004 no 1034 0.329766551376122 1540 15991618 SGTC_977 1348-1378 135 µM 0.437677013506127 0.312414097058067 no 1035 0.330810217409519 1535 X977 SGTC_2738 aclarubicin 5.55 µM 0.436211046069362 0.31296567474167 no 1036 0.331341807146986 1611 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1193 1488-0126 41.5 µM 0.436126759480345 0.31299740074467 no 1037 0.331372381532283 1563 1384710 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.436069432347057 0.313018979829958 no 1038 0.331393177201078 1560 2724 A muscle relaxant with antifungal properties. SGTC_1007 4101-0031 70 µM 0.435992227837519 0.313048042171387 no 1039 0.331421184296703 1676 1146276 SGTC_1097 itavastatin 7.23 µM 0.435116363907669 0.313377827745341 no 1040 0.331738983077025 1581 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_284 0988-0104 32.6 µM 0.434174139389742 0.313732766477565 no 1041 0.332080995403018 1630 4666532 SGTC_2601 securinine 100 µM 0.433947275479853 0.313818252551385 no 1042 0.332163364261792 1534 442872 A GABA receptor antagonist. SGTC_1321 1326-2144 215 µM 0.433934954946803 0.313822895418232 no 1043 0.33216783778481 1654 3513030 SGTC_1883 5-benzylidenerhodanine 20 µM 0.433783147126861 0.313880105061544 no 1044 0.332222960396436 1669 1273210 SGTC_2270 7924575 90.91 µM 0.433695404004453 0.313913173598585 no 1045 0.332254822268733 1706 1262135 SGTC_2012 4023501 200 µM 0.429959515278909 0.315322535200978 no 1046 0.333612545567291 1534 3477460 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.428707555414501 0.31579543942533 no 1047 0.334068030785873 1638 140250 A respiratory chain inhibitor. SGTC_653 0203-0016 55.2 µM 0.42843692251357 0.315897705582682 no 1048 0.334166524002173 1620 295302 SGTC_3355 9151058 44.0485 µM 0.427101756962599 0.316402441107441 no 1049 0.334652606653288 1570 17015728 SGTC_2030 5175110 200 µM 0.426824725422599 0.316507210836985 no 1050 0.334753497985814 1643 2831986 SGTC_2257 7960413 200 µM 0.425705138562646 0.316930773987774 no 1051 0.335161358626507 1674 2974689 YIL048W NEO1 SGTC_504 lovastatin 124 µM 0.425037328859097 0.317183534709676 no 1052 0.335404731412456 1539 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3008 9078912 71.4286 µM 0.423839190613514 0.317637234382169 no 1053 0.335841547244192 1567 16648731 SGTC_2862 9027634 71.43 µM 0.421938741491757 0.318357440338582 no 1054 0.336534865627674 1519 5012562 SGTC_605 1315-0399 119 µM 0.421358648479423 0.318577412970841 no 1055 0.336746604991213 1637 24020461 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.421299653629526 0.318599787540652 no 1056 0.336768141562714 1615 688801 SGTC_386 1509-0011 3.07 µM 0.42119798006525 0.318638350124377 no 1057 0.336805259617924 1588 3107280 SGTC_2099 5377090 177.372 µM 0.420235048687612 0.319003666516464 no 1058 0.337156876574865 1573 2243829 SGTC_2359 9039622 200 µM 0.419375043359273 0.319330083585486 no 1059 0.33747103012767 1666 6463596 SGTC_3188 9110789 49.47 µM 0.419204442507408 0.319394852202832 no 1060 0.337533362826561 1667 849217 SGTC_359 0081-0058 15.9 µM 0.418499382235351 0.319662586785779 no 1061 0.337791019062831 1746 3494159 SGTC_1416 3966-0321 25.3 µM 0.417936521446008 0.319876391035288 no 1062 0.337996764705189 1612 582530 YLR208W SEC13 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.41530010207504 0.320878638125143 no 1063 0.338961113254814 1629 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3206 9114350 49.47 µM 0.415067296764788 0.320967203040851 no 1064 0.339046319543225 1570 17087243 SGTC_561 1550-0330 72.9 µM 0.413851807356511 0.321429770715969 no 1065 0.339491319922959 1572 6812934 SGTC_3300 9124615 50.48 µM 0.41120814278797 0.32243680186724 no 1066 0.340459958990081 1682 24824903 SGTC_2052 5265182 7.135 µM 0.409137992053118 0.323226279799131 no 1067 0.341219198318219 1711 1239884 SGTC_3251 9135047 49.47 µM 0.408830912359012 0.323343456437652 no 1068 0.341331876366986 1714 17682963 SGTC_1671 st016596 74.5 µM 0.406408938827693 0.324268255744667 no 1069 0.342221076433359 1603 2829167 SGTC_2552 juarezic acid 87.02 µM 0.405609328694102 0.324573815101159 no 1070 0.342514836699106 1620 1549512 SGTC_932 2857-0803 154 µM 0.404374407724428 0.325045954183299 no 1071 0.342968708355026 1725 674898 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.4038535998873 0.325245155477286 no 1072 0.34316018934456 1591 279621 SGTC_753 1322-0200 289 µM 0.403563473117682 0.32535614634154 no 1073 0.343266875258786 1628 5403907 SGTC_960 1222-0186 7.7 µM 0.40346646843064 0.325393259900032 no 1074 0.343302548775973 1686 3126296 SGTC_1814 st052110 31.539 µM 0.40274938651307 0.325667665919681 no 1075 0.34356629926338 1727 674163 SGTC_2414 st077232 92.9 µM 0.400528656166394 0.326518072593251 no 1076 0.344383590701354 1545 729801 SGTC_985 1493-0307 8.71 µM 0.397736387290037 0.327588624669461 no 1077 0.345412256160514 1753 3278274 SGTC_544 k015-0020 52.4 µM 0.394533316085948 0.328818425273672 no 1078 0.346593667526767 1654 3008304 SGTC_1359 1582-0056 520 nM 0.394184042261782 0.328952639380963 no 1079 0.346722583173556 1670 3661189 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.392738307216684 0.329508420861672 no 1080 0.34725638715633 1693 5377381 SGTC_2911 7942208 15.64 µM 0.390898112261689 0.330216388884306 no 1081 0.347936274689035 1612 1243384 SGTC_2141 5621638 7.665 µM 0.390825108327025 0.330244487845127 no 1082 0.347963257186307 1749 2856238 SGTC_699 0375-0592 111 µM 0.389908768359558 0.330597265295946 no 1083 0.348302004927194 1714 762578 SGTC_2730 imipramine 71.33 µM 0.3894630384242 0.330768919233324 no 1084 0.34846682380334 1705 3696 A tricyclic antidepressant. SGTC_486 niguldipine 82 µM 0.389182481668206 0.330876981996618 no 1085 0.348570580779964 1660 1236 A calcium channel blocker. SGTC_1115 galangin 695.678 nM 0.388678898014827 0.331070983948206 no 1086 0.348756847152418 1734 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_269 exalamide 29 µM 0.387865660892472 0.33138437341419 no 1087 0.349057725641453 1683 3316 A derivative of salicylamide. SGTC_190 3970-0790 3.722 µM 0.386420353611718 0.33194162912238 no 1088 0.349592689273847 1725 2832352 SGTC_2380 9035439 200 µM 0.38610302561577 0.332064028611468 no 1089 0.34971018457508 1734 6462575 SGTC_2172 5754775 163.918 µM 0.384489625607435 0.332686624867924 no 1090 0.35030779183538 1600 2263357 SGTC_3301 9125354 19.7965 µM 0.384392000549349 0.332724312313205 no 1091 0.350343964304221 1604 41905162 SGTC_1745 st081495 74 µM 0.383990149079994 0.332879461953396 no 1092 0.35049287438085 1679 13842402 YBL026W LSM2 SGTC_582 0987-0078 156 µM 0.383781730128588 0.33295994107941 no 1093 0.350570115156635 1656 1625765 SGTC_2217 6934799 96.0675 µM 0.38218444447523 0.333576973972737 no 1094 0.351162279589451 1722 675606 SGTC_2280 7785178 200 µM 0.381544650525625 0.333824253403821 no 1095 0.351399572990998 1667 2954328 SGTC_1333 1482-0047 286 µM 0.380981916501811 0.334041808958534 no 1096 0.351608333498903 1756 3811116 SGTC_636 0kpi-0074 126 µM 0.380429002564289 0.334255622354128 no 1097 0.35181349459261 1652 616434 SGTC_1546 5-methoxyflavanone 78.7 µM 0.380337166706553 0.334291140752998 no 1098 0.351847574863463 1746 147795 SGTC_2358 9037157 4 µM 0.379578115506625 0.334584767871566 no 1099 0.352129304189694 1692 2388925 SGTC_3272 9137413 49.47 µM 0.378727893566822 0.334913783129388 no 1100 0.352444968822564 1560 17614870 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.376608396655702 0.335734528374381 no 1101 0.353232323428151 1739 77254 SGTC_2691 st077356 60.2 µM 0.374750921429977 0.336454454398473 no 1102 0.353922858787104 1756 2839272 SGTC_3100 9120536 49.47 µM 0.374394312068936 0.336592738896275 no 1103 0.35405548703627 1754 16421196 SGTC_1718 roemerine 11.9335 µM 0.374037005765002 0.336731315818068 no 1104 0.354188392249367 1654 235224 An aporphine alkaloid with mutagenic activity. SGTC_211 3455-0679 143.504 µM 0.373470097047594 0.336951229986191 no 1105 0.354399298535912 1678 748649 SGTC_484 loperamide 105 µM 0.372512104893292 0.337322979174953 no 1106 0.354755800532886 1677 3955 An opioid-receptor agonist. SGTC_2624 nerol 100 µM 0.371774067956954 0.33760948302917 no 1107 0.355030536380372 1755 637566 A natural product oil. SGTC_672 1441-0018 53.7 µM 0.37146952749852 0.337727732223834 no 1108 0.355143924206247 1622 251141 SGTC_1155 4088-0394 48.2 µM 0.370758092555573 0.338004035792879 no 1109 0.355408858724756 1623 2326248 SGTC_2091 4-phenylthiadiazole 200 µM 0.370456514512748 0.338121187529517 no 1110 0.355521185853676 1676 270010 SGTC_1166 k206-0078 225 µM 0.370220443917215 0.338212903024164 no 1111 0.355609122538432 1628 5404595 SGTC_226 1,3-diallylurea 8.28947 mM 0.370092221548167 0.338262722562064 no 1112 0.355656888802882 1694 74537 YKL182W FAS1 SGTC_1313 1220-0047 237 µM 0.369531431254398 0.338480645370511 no 1113 0.355865824824774 1727 3528706 SGTC_162 k030-0015 37.8 µM 0.369434128807621 0.338518462559268 no 1114 0.355902081620778 1819 1809920 YMR134W ERG29 SGTC_1100 amiodarone 5.07 µM 0.368430611393948 0.338908580660607 no 1115 0.35627608783196 1833 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2792 7535235 81.82 µM 0.367792131280455 0.33915688024907 no 1116 0.356514118373343 1599 1281891 SGTC_2385 9074692 200 µM 0.36738335506427 0.339315886603582 no 1117 0.356666542805123 1643 17046906 SGTC_181 1447-1644 8.07 µM 0.366232479960182 0.339763709260134 no 1118 0.357095803874392 1788 534600 SGTC_949 1165-0505 146 µM 0.365254612106451 0.340144390050458 no 1119 0.357460677770426 1645 6244267 SGTC_988 1497-1057 103 µM 0.365107351329831 0.340201732325897 no 1120 0.357515636794847 1805 3533044 SGTC_1789 tunicamycin 25 nM 0.365106219466324 0.340202173079629 no 1121 0.357516059227764 1761 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3122 9126309 49.47 µM 0.364489882541994 0.340442210405642 no 1122 0.357746113768203 1731 17591206 SGTC_2669 eugenol 100 µM 0.363681401345562 0.340757177867671 no 1123 0.358047966630355 1783 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_905 2-aminofluorene 215 µM 0.362715087074199 0.341133779493666 no 1124 0.3584088641593 1658 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.362491657923599 0.341220879076177 no 1125 0.35849232814471 1832 5024745 SGTC_2876 9059903 25.97 µM 0.361573254852957 0.341578989768765 no 1126 0.358835476904634 1686 6916095 SGTC_1746 st038117 42 µM 0.360508523094427 0.341994336599521 no 1127 0.359233442015561 1678 2898218 SGTC_994 3910-0338 138 µM 0.359292319524769 0.342469005897722 no 1128 0.359688209704267 1767 3479481 SGTC_2944 9067346 25.62 µM 0.357491394877975 0.343172341677547 no 1129 0.360361983535084 1720 6473075 SGTC_996 3970-0799 1.8 µM 0.357237561011337 0.343271518097432 no 1130 0.360456984472974 1809 6615648 YGL040C HEM2 SGTC_2026 5148700 152 µM 0.353973428793655 0.344547819729983 no 1131 0.361679398224698 1683 79838 SGTC_22 0964-0034 14.468 µM 0.353922379889022 0.344567794365515 no 1132 0.361698527234007 1674 138402 SGTC_3087 9117406 49.47 µM 0.352592697948082 0.345088230572652 no 1133 0.362196906322037 1687 42546093 SGTC_1039 k821-0043 94 µM 0.352178298283486 0.345250486158042 no 1134 0.362352275576784 1792 15992768 SGTC_2707 st078556 66.6 µM 0.351192963954764 0.345636401818095 no 1135 0.362721794164207 1824 17250899 SGTC_1562 morin hydrate 59.1 µM 0.350535897157304 0.345893837558163 no 1136 0.362968277456252 1726 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1281 0884-0031 11.8 µM 0.349959441072018 0.346119749078672 no 1137 0.363184568278608 1668 1548255 SGTC_44 0929-0055 61.211 µM 0.349787262428502 0.34618723603232 no 1138 0.363249179515896 1644 1379590 SGTC_1294 1000-1494 117 µM 0.349505546008311 0.346297667827522 no 1139 0.363354903959717 1658 712797 YDL207W GLE1 SGTC_1328 1441-0025 69.2 µM 0.348231023755343 0.346797439022325 no 1140 0.363833345270591 1604 4562601 SGTC_1419 3993-2473 62.6 µM 0.348186141149755 0.346815043450445 no 1141 0.363850197571072 1738 704026 SGTC_2175 5807670 165.306 µM 0.347726508084189 0.346995345624275 no 1142 0.36402279349191 1788 241186 SGTC_2446 5162541 200 µM 0.347303246479486 0.347161410858309 no 1143 0.364181756036203 1667 1549321 SGTC_2899 9053889 58.44 µM 0.347218484735959 0.347194670365247 no 1144 0.364213592449772 1826 6470052 SGTC_939 1165-0479 45.3 µM 0.3448435978332 0.348127025543657 no 1145 0.365105977414789 1806 1377347 SGTC_2018 5133068 143 µM 0.344462939067614 0.348276553677555 no 1146 0.365249081447777 1691 785362 SGTC_252 miconazole 1.30953 nM 0.344254366630932 0.348358493877306 no 1147 0.365327499677582 1773 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_286 k060-0067 22.9 µM 0.342063641206362 0.349219573746105 no 1148 0.366151499448128 1704 5985051 SGTC_2070 5230947 200 µM 0.341278326171231 0.349528436651287 no 1149 0.366447031373491 1804 2835538 SGTC_172 1112-0046 2.638 µM 0.341059212672496 0.349614631360548 no 1150 0.366529502912742 1719 2802135 YIL048W NEO1 SGTC_2806 7952793 58.44 µM 0.340982315331207 0.349644883019126 no 1151 0.366558447557027 1740 2972490 SGTC_2111 5486399 200 µM 0.340731467294628 0.349743574070872 no 1152 0.366652873615493 1677 689674 SGTC_2819 7996655 46.38 µM 0.3401929544386 0.349955475278116 no 1153 0.366855611830929 1794 6456960 SGTC_133 0724-0033 378.92 µM 0.339319581880411 0.350299240880745 no 1154 0.367184496289339 1718 280309 SGTC_2166 5933061 31.504 µM 0.339158614905607 0.350362612014779 no 1155 0.367245122001817 1825 2877375 SGTC_2426 5582046 32.21 µM 0.338261820536288 0.350715747456442 no 1156 0.367582946229723 1759 2251934 SGTC_395 anisomycin 6.25 µM 0.33644959482172 0.351429750655209 no 1157 0.368265927853575 1719 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3141 9094609 49.47 µM 0.335372118783489 0.351854516888866 no 1158 0.368672198662968 1657 25236309 YDL196W YDL196W SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.33459435968817 0.352161242683636 no 1159 0.368965550116189 1670 5355888 SGTC_54 0159-0055 9 µM 0.334551707695738 0.352178066185705 no 1160 0.368981639600304 1835 3319099 SGTC_2616 abietic acid 100 µM 0.333721683019112 0.352505515761808 no 1161 0.369294793013017 1898 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2314 7727897 200 µM 0.332014805410335 0.353179232311882 no 1162 0.369939039724733 1657 900724 SGTC_1739 st037196 92.5 µM 0.33076638613907 0.353672283823616 no 1163 0.370410476496334 1868 612214 SGTC_1093 fluphenazine 7.97 µM 0.32771226280515 0.354879515078518 no 1164 0.371564615303376 1768 6602611 An atypical antipsychotic. SGTC_454 lyso-paf C-16 6.67 µM 0.327054976970466 0.355139517608215 no 1165 0.371813151977768 1629 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2064 5220758 200 µM 0.325933817464511 0.355583170246019 no 1166 0.372237214467677 1746 788518 SGTC_2277 7947813 106.88 µM 0.324212648054427 0.356264632775541 no 1167 0.372888523531163 1851 1246798 SGTC_2344 7990960 76.95 µM 0.32402224176446 0.356340048584076 no 1168 0.372960597689348 1742 140813 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.32381965769341 0.356420293917355 no 1169 0.373037286364058 1777 6708739 YPR165W RHO1 SGTC_2785 7756463 72.73 µM 0.322927544563586 0.35677374337511 no 1170 0.373375057700062 1681 2201551 SGTC_1962 st076595 64.5 µM 0.321305229323571 0.357416809239442 no 1171 0.373989546961515 1743 279619 SGTC_425 3825-7017 13.1 µM 0.319257715125193 0.358228996872681 no 1172 0.374765547294671 1808 3397440 SGTC_1223 0764-0573 147 µM 0.318177730693395 0.358657653222527 no 1173 0.375175062008845 1747 1609797 SGTC_2467 5474540 200 µM 0.317644610145474 0.35886931966235 no 1174 0.375377265640537 1720 5413519 SGTC_2181 6316240 54.2555 µM 0.317296720597018 0.35900746666165 no 1175 0.375509232745997 1690 12779990 SGTC_2584 androsterone 48.74 µM 0.317047307121283 0.359106520146464 no 1176 0.375603853277335 1790 2754130 A steroid. SGTC_1710 st031758 61.5 µM 0.316681751908424 0.359251715935097 no 1177 0.375742548270132 1841 5394341 SGTC_1214 0358-0031 63.7 µM 0.316351170290303 0.359383037979946 no 1178 0.375867987787602 1909 4301366 SGTC_60 0986-0278 202 µM 0.316150658748795 0.35946269837259 no 1179 0.37594407848028 1584 3110598 SGTC_2961 9083290 32.55 µM 0.316066391774613 0.359496178269814 no 1180 0.375976057792147 1772 17741490 SGTC_3164 9100705 49.47 µM 0.315348916546546 0.359781280191138 no 1181 0.376248374078366 1841 17174235 SGTC_1181 1222-0449 220 µM 0.31519996398493 0.359840479007418 no 1182 0.376304916453333 1828 658318 SGTC_2282 7944268 200 µM 0.314953763189752 0.35993833495223 no 1183 0.376398380066175 1831 2970414 SGTC_2736 butenafine 14.65 µM 0.314690327968796 0.360043051127224 no 1184 0.376498394298687 1830 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_277 nystatin 15.5 µM 0.314279980812844 0.36020618609366 no 1185 0.376654200748027 1703 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2765 myclobutanil 7.74 µM 0.31424850278704 0.360218701346135 no 1186 0.376666153603109 1738 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2073 5212005 126 µM 0.313695673303721 0.360438523544496 no 1187 0.376876093613442 1892 691789 SGTC_1870 st057514 26.5 µM 0.313024170253967 0.360705596095589 no 1188 0.377131149526297 1739 5393161 SGTC_1647 st011722 22.4 µM 0.312929999882492 0.360743055302268 no 1189 0.377166922394792 1787 2854783 SGTC_257 daunorubicin 18.5 µM 0.311178937849143 0.361439837980097 no 1190 0.377832296944504 1895 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_742 0kpi-0133 140 µM 0.311175888153105 0.361441051917041 no 1191 0.377833456095342 1885 2728852 SGTC_246 cycloheximide 667 µM 0.310251337234243 0.36180913531769 no 1192 0.378184916861454 1730 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_658 3253-0951 102 µM 0.308993406304765 0.362310149712734 no 1193 0.378663271285846 1788 1184878 SGTC_264 promethazine 12.5 mM 0.30879026809334 0.362391078664012 no 1194 0.378740536278262 1877 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2096 5468907 200 µM 0.307434453010971 0.362931383983095 no 1195 0.379256353702245 1889 759785 SGTC_2395 5646831 180.19 µM 0.307077812503792 0.363073554035257 no 1196 0.37939207270447 1825 6808628 SGTC_703 3875-0075 71.8 µM 0.305805614329819 0.363580852716206 no 1197 0.379876326757881 1793 2850814 SGTC_1452 4194-0072 190 µM 0.305795737087598 0.363584792278794 no 1198 0.379880087204701 1910 1343545 SGTC_1118 chelidonine 707.474 nM 0.304987430485627 0.363907236231462 no 1199 0.380187862783406 1919 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_512 prima-1 270 µM 0.304536967938283 0.364086973406999 no 1200 0.380359416493837 1848 322968 A re-activator of the apoptotic function of mutant p53. SGTC_431 k089-0097 107 µM 0.303695979648432 0.364422612619114 no 1201 0.3806797606036 1769 5499420 SGTC_2773 thioridazine 9.09 µM 0.302745754603919 0.36480197343234 no 1202 0.381041812959528 1817 5452 An antipsychotic. SGTC_2683 piperine 63.03 µM 0.302591634610937 0.364863515646398 no 1203 0.381100545197256 1789 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3126 9127922 49.47 µM 0.302472808779354 0.364910966797909 no 1204 0.381145829362331 1808 45595682 SGTC_739 1486-1183 203 µM 0.301621330375498 0.365251051260937 no 1205 0.381470372791251 1906 4346692 SGTC_1684 st024538 14.6195 µM 0.301440102590922 0.36532344817651 no 1206 0.381539459046324 1761 6732859 SGTC_2109 5483026 200 µM 0.30137168663544 0.365350780245625 no 1207 0.38156554102946 1791 759335 SGTC_450 aminopyrene 156 nM 0.300694406089734 0.365621389657027 no 1208 0.381823767394577 1858 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_957 1187-1561 14.1 µM 0.299994677803478 0.365901038384403 no 1209 0.382090607633573 1811 1538454 SGTC_2376 9072922 81.32 µM 0.299869511902329 0.365951068869484 no 1210 0.382138345355525 1808 17087968 SGTC_2354 9060492 162 µM 0.299513088441194 0.366093548580194 no 1211 0.382274293503182 1885 6471895 SGTC_1818 st052136 56.3 µM 0.299153366453792 0.366237365595143 no 1212 0.382411514500773 1728 674169 SGTC_704 1310-0270 142 µM 0.298984454309172 0.366304903232397 no 1213 0.382475953503653 1731 5718033 SGTC_953 1188-0045 9.7 µM 0.298905265157538 0.366336567557543 no 1214 0.382506164826025 1822 6144426 SGTC_2891 9063876 19.48 µM 0.29848831510496 0.36650330289992 no 1215 0.382665246542552 1943 6472478 SGTC_1061 3448-9325 110 µM 0.296390102193401 0.367342745124861 no 1216 0.383466091626521 1889 723482 SGTC_2249 haloperidol 116.36 µM 0.295506433255579 0.367696468932104 no 1217 0.383803519316786 1828 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3119 9125183 49.47 µM 0.295150947284202 0.367838798078101 no 1218 0.383939285984153 1906 22695334 SGTC_424 splitomicin 100 mM 0.293978133547304 0.368308496777723 no 1219 0.384387306185724 1711 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_521 r062-0005 13.8 µM 0.292362134403259 0.36895600867876 no 1220 0.385004878217912 1753 2832033 SGTC_2346 9031566 143.75 µM 0.291418305111076 0.369334362257918 no 1221 0.385365708169054 1895 4771086 SGTC_1161 k007-0610 110 µM 0.289981330666644 0.369910646313133 no 1222 0.385915260112487 1877 5843850 SGTC_1994 st072947 40.9 µM 0.289857189844254 0.36996044546583 no 1223 0.385962746897551 1840 5286565 YDL195W SEC31 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.286670000855999 0.371239732389944 no 1224 0.387182504877431 1778 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2580 diallyl disulphide 81.36 µM 0.286405506338553 0.371345960459421 no 1225 0.387283778910868 1802 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3025 9087895 49.47 µM 0.285470713679936 0.371721476663893 no 1226 0.387641769207334 1908 17173641 SGTC_2121 5257820 149.641 µM 0.284300311141086 0.37219181196812 no 1227 0.388090123860461 1939 791256 SGTC_1846 st056244 14.8 µM 0.28384737569397 0.372373878804955 no 1228 0.388263673228194 1857 5393182 SGTC_460 trequinsin 123 µM 0.283524720096545 0.372503594345095 no 1229 0.388387317425989 1859 5537 A vasodilator. SGTC_2227 7312221 64.1025 µM 0.283210668508408 0.372629864750918 no 1230 0.388507675362075 1877 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3310 9130229 44.1445 µM 0.283160457694034 0.372650054232186 no 1231 0.388526919276257 1889 7761258 SGTC_709 3807-1509 243 µM 0.282931711497407 0.372742036196649 no 1232 0.388614592540573 1831 1886677 YPL242C IQG1 SGTC_186 3455-3465 67.277 µM 0.282121883653105 0.373067737305541 no 1233 0.388925026886634 1831 755278 SGTC_2757 clomiphene 4.22 µM 0.28172377081058 0.373227885846012 no 1234 0.389077662994636 1937 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.281277120334315 0.373407585653527 no 1235 0.389248928765436 1915 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1506 4226-2149 212 µM 0.281123911036817 0.373469232324285 no 1236 0.389307681021007 1838 991114 SGTC_2406 ethylparaben 405.7 µM 0.28025327755078 0.373819609686598 no 1237 0.389641597028162 1578 8434 A possible steroid mimic. SGTC_47 0149-0135 24.25 µM 0.278847670887197 0.374385501434657 no 1238 0.390180864365016 1691 5239155 SGTC_886 0866-0150 153 µM 0.278804876067275 0.374402734714415 no 1239 0.390197286111912 1961 271463 SGTC_2791 5663188 71.43 µM 0.277848375410464 0.374787978608042 no 1240 0.390564377214026 1909 54690634 SGTC_1454 4239-0054 42.6 µM 0.277616938081305 0.374881211993747 no 1241 0.390653214182137 1930 1340767 SGTC_187 1488-2104 32.728 µM 0.276553555570948 0.375309684302179 no 1242 0.391061465704287 1901 2852859 SGTC_1481 3346-2004 36 µM 0.275158766785869 0.375871924487435 no 1243 0.391597131984337 1841 2770522 SGTC_755 1995-0008 37.3 µM 0.274683638201141 0.376063509358905 no 1244 0.391779651316378 1913 689533 SGTC_1044 1222-0021 1.78 µM 0.27405638119894 0.376316483359472 no 1245 0.392020646837567 1863 4306703 SGTC_3053 9095903 49.47 µM 0.273945449240487 0.376361227972868 no 1246 0.392063271808002 1890 17174018 SGTC_2506 ethyl hematommate 54.16 µM 0.273363332398854 0.376596053115814 no 1247 0.392286968096589 1754 3940691 An allergen. SGTC_2491 paeonol 100 µM 0.272376980061207 0.376994050526002 no 1248 0.392666085526816 1809 11092 Increases levels of cortical cytochrome oxidase. SGTC_21 0849-0113 22.993 µM 0.271651223059701 0.377286980107902 no 1249 0.392945104800538 1792 1560156 SGTC_2031 5180455 200 µM 0.271444835126183 0.377370295179449 no 1250 0.393024461261668 1814 29949 SGTC_968 1309-0633 340 µM 0.269804636147752 0.378032616431222 no 1251 0.393655277962838 1940 3761976 SGTC_1993 st073995 70.8 µM 0.268624581214988 0.378509350974656 no 1252 0.394109297136453 1859 3098394 SGTC_1404 3909-7820 48.3 µM 0.266747803135958 0.379267937914314 no 1253 0.394831672703539 1945 23741373 SGTC_1109 tnp00067 928.257 nM 0.266397009012701 0.379409779314594 no 1254 0.394966734246203 1816 676295 SGTC_1306 1185-0270 9.02 µM 0.26561487713001 0.3797260878469 no 1255 0.395267913385988 1924 1548076 SGTC_1006 4099-6547 255 µM 0.265204050778143 0.379892265845774 no 1256 0.395426137265996 1898 3146833 SGTC_216 k038-0035 28.382 µM 0.264422067679859 0.380208636877998 no 1257 0.395727354463763 1938 4444231 YPR107C YTH1 SGTC_2947 9072639 7.68 µM 0.263895981659922 0.380421523397639 no 1258 0.39593003604785 1783 16488146 SGTC_339 3091-4833 71.4 µM 0.26293021873259 0.380812424274912 no 1259 0.396302182173192 1880 3240077 SGTC_173 1273-0061 2.693 µM 0.262924218242403 0.380814853405888 no 1260 0.396304494691875 1760 2847414 YPL266W DIM1 SGTC_1279 0874-0590 65.2 µM 0.26227493962564 0.381077723469485 no 1261 0.39655474061009 1889 3523074 SGTC_1054 3429-0080 167 µM 0.260245310643405 0.381899802280943 no 1262 0.397337277580898 1910 1162877 SGTC_2032 5185112 25.99 µM 0.25996478518438 0.38201346801696 no 1263 0.397445468629147 1905 5718189 SGTC_2821 7996764 71.43 µM 0.25971395258454 0.382115111156409 no 1264 0.397542214630296 1874 2987135 SGTC_1926 methyl fluorone black 53.6 µM 0.259594345316212 0.382163581634275 no 1265 0.397588349310043 1866 72721 Reacts with homocysteine. SGTC_260 nsc-65238 3.989 µM 0.25602015917309 0.383612858572614 no 1266 0.398967635591719 1921 3246252 SGTC_1804 st050076 49.1 µM 0.255227591649688 0.383934453867392 no 1267 0.399273660765138 1896 3895976 SGTC_2396 5342950 42.78 µM 0.254234661695739 0.384337461796771 no 1268 0.399657136971946 1843 1886677 SGTC_3200 9114385 49.47 µM 0.253634078166095 0.384581285867982 no 1269 0.399889133371556 1798 17018030 YLR208W SEC13 SGTC_1772 st048439 82.2 µM 0.25342304833134 0.384666970315196 no 1270 0.399970659423041 1839 2927068 YDL195W SEC31 SGTC_853 0419-0306 21 µM 0.253177753812414 0.38476657433304 no 1271 0.400065428249892 1821 762713 SGTC_1227 3909-8010 46.6 µM 0.251496553309684 0.3854494451155 no 1272 0.400715113320781 1881 15982272 SGTC_3318 9139014 38.6185 µM 0.250299182789542 0.385936010370301 no 1273 0.401177994199232 1856 16643984 SGTC_334 1502-1024 68.5 µM 0.249274120762944 0.386352698733575 no 1274 0.401574374118546 1891 3296216 SGTC_3332 9141069 11.198 µM 0.248677623567357 0.386595235594086 no 1275 0.401805079502069 1793 17332883 SGTC_2135 5326629 150.42 µM 0.247291034428027 0.387159196344686 no 1276 0.402341498426797 1822 5020077 SGTC_215 1287-0124 461.5 µM 0.246046255655217 0.387665682254532 no 1277 0.402823213014286 2009 5560863 SGTC_1197 1601-0112 267 µM 0.246032129440613 0.387671431144773 no 1278 0.402828680539513 1811 7350313 SGTC_1336 1486-0901 104 µM 0.245189455406 0.38801441540476 no 1279 0.403154870306224 1901 5006114 SGTC_2348 9022543 33.42 µM 0.244715093923278 0.388207527948683 no 1280 0.403338520036279 1885 3162678 YDL140C RPO21 SGTC_3058 9093861 49.47 µM 0.244544781395231 0.388276868919815 no 1281 0.403404461979847 1918 17217477 SGTC_1524 corynanthine 62.1 µM 0.244325116341356 0.38836630851616 no 1282 0.403489516387912 1905 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_99 0109-0120 622.8 µM 0.241961757632843 0.389328955516251 no 1283 0.404404897917122 1953 759414 SGTC_927 2425-1185 123 µM 0.241303383419887 0.389597246821821 no 1284 0.404659994385909 1822 730375 SGTC_3090 9117696 49.47 µM 0.239985438702689 0.390134474919596 no 1285 0.405170772512842 1981 7923821 SGTC_796 1234-0020 70.7 µM 0.238307226410617 0.390818861022162 no 1286 0.405821408460719 1842 46495034 SGTC_1995 st072814 61.1 µM 0.237752485320604 0.391045162622232 no 1287 0.406036536600372 1839 5769371 SGTC_3157 9099274 49.47 µM 0.23764588035732 0.391088655379679 no 1288 0.406077881170011 2008 17217662 SGTC_203 k066-0004 30.888 µM 0.236707095865396 0.391471719998738 no 1289 0.406442014842991 2027 6795412 SGTC_635 k038-0028 24.7 µM 0.236043244830833 0.39174266345759 no 1290 0.406699556792525 1938 4035102 SGTC_3184 9108758 49.47 µM 0.235927354228875 0.391789968313198 no 1291 0.406744520856618 1897 902885 SGTC_2226 7298446 200 µM 0.235737826453172 0.391867334237891 no 1292 0.406818057846804 1986 3283010 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.235737232450906 0.391867576718492 no 1293 0.406818288325518 2022 6708630 An antioxidant. SGTC_1213 1315-0166 115 µM 0.235209581018375 0.392082988496863 no 1294 0.407023035002556 1761 768401 SGTC_1876 myriocin 605 nM 0.235174874371213 0.392097158519527 no 1295 0.407036503251756 2013 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_979 1426-2828 121 µM 0.233973970722541 0.392587551229029 no 1296 0.407502593100077 1955 747872 SGTC_1301 naphtanilide LB 4.81 µM 0.233251145068262 0.392882801603426 no 1297 0.407783196443712 1987 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_459 nigericin 15.3 µM 0.232497040731262 0.393190893983451 no 1298 0.408075992703844 1915 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2461 5755302 26.15 µM 0.232479057089572 0.393198242090639 no 1299 0.408082975843827 1998 2788904 SGTC_1981 st071826 47 µM 0.22992421161976 0.394242536177737 no 1300 0.409075331066767 1892 11838600 SGTC_1912 st060209 90.8 µM 0.227714222009585 0.395146484241267 no 1301 0.409934207661551 1840 688787 SGTC_2902 5787006 60.46 µM 0.227398407737497 0.395275707401171 no 1302 0.410056979151089 1859 591003 SGTC_707 0865-0008 204 µM 0.226988089191236 0.395443616504531 no 1303 0.410216501953559 1944 723043 SGTC_2433 5607874 27.82 µM 0.226203790315071 0.395764618503085 no 1304 0.41052146138309 1877 2252428 SGTC_20 0481-0013 4.944 µM 0.225983376034975 0.395854843565319 no 1305 0.410607174954931 1858 182045 SGTC_2658 polymyxin b sulfate 77.05 µM 0.225235415460022 0.396161057628966 no 1306 0.410898069820227 1909 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2355 9061122 103.12 µM 0.225226007284754 0.396164909731862 no 1307 0.410901729135518 1994 5302957 SGTC_65 0798-0905 34.986 µM 0.224152946406193 0.396604332448811 no 1308 0.411319147594978 2041 3602145 SGTC_1051 3253-3903 78 µM 0.22409320274758 0.39662880158091 no 1309 0.411342390709616 1939 5509239 SGTC_1667 st014849 34.6 µM 0.223534961912679 0.39685745921014 no 1310 0.411559587879021 1959 5348460 SGTC_146 3448-8650 53.125 µM 0.223155229041156 0.397013019552738 no 1311 0.411707347678836 1921 2891488 YIL048W NEO1 SGTC_2900 5328528 85.29 µM 0.222717722721472 0.397192267525924 no 1312 0.411877603523403 1906 795359 SGTC_1248 0469-0687 58.6 µM 0.222227584351652 0.397393104838513 no 1313 0.412068360864551 1951 4017482 SGTC_2168 5727979 200 µM 0.220624185668896 0.398050297446633 no 1314 0.412692533809744 1968 695210 SGTC_2295 7971645 200 µM 0.220570820044202 0.398072175653497 no 1315 0.412713311849415 1960 2978226 YKL099C UTP11 SGTC_668 1682-0499 62.6 µM 0.220430002919398 0.398129907729185 no 1316 0.412768140523763 1897 682214 SGTC_268 camptothecin 39.6153 µM 0.218776171203695 0.398808110727615 no 1317 0.413412204927546 1941 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2463 5473429 200 µM 0.216924977334218 0.399567610436418 no 1318 0.414133405971762 1915 5399405 SGTC_2713 st079149 53.4 µM 0.215672008308296 0.40008188902294 no 1319 0.41462171092756 1927 3103253 SGTC_127 0180-0333 59.125 µM 0.215396436299665 0.400195020276978 no 1320 0.414729124111718 2048 771601 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.214184844655457 0.400692517215822 no 1321 0.415201457034333 1809 641818 YHR062C RPP1 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.212956927018414 0.401196882243244 no 1322 0.415680279637655 1940 2346 DNA damaging agent; causes G2/M arrest. SGTC_1016 4226-1401 38 µM 0.212700736754279 0.401302132740207 no 1323 0.415780196033628 2037 2901613 SGTC_2564 betulinic acid 100 µM 0.211694262239468 0.401715691348203 no 1324 0.4161727823633 2106 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2725 haloperidol 53.21 µM 0.211292214418341 0.401880922889294 no 1325 0.416329628892305 2016 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1206 3978-0017 132 µM 0.210348414202937 0.40226886990193 no 1326 0.416697875681565 1973 3873677 SGTC_924 2046-0044 21.3 µM 0.210169194485668 0.402342548663937 no 1327 0.416767810917091 2048 3623589 SGTC_1850 st056238 17 µM 0.209859200649518 0.402469997976569 no 1328 0.416888783132592 2041 5393177 SGTC_255 tunicamycin 200.472 nM 0.209591704399013 0.402579983378114 no 1329 0.416993177386074 2052 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2201 6605497 169.863 µM 0.209219348773301 0.402733096240769 no 1330 0.417138504259487 2020 670741 SGTC_2698 st077697 67.5 µM 0.209040093965875 0.402806811249384 no 1331 0.417208469751141 1853 3154499 SGTC_1644 st010134 20.9 µM 0.208726771464392 0.402935667252539 no 1332 0.41733076990918 2058 3818134 SGTC_1305 1181-0477 144 µM 0.207700073019633 0.403357977752391 no 1333 0.417731580330081 2052 6252086 SGTC_509 pifithrin 175 µM 0.206922945018091 0.403677707757517 no 1334 0.418035018384854 2026 4817 A p53 inhibitor. SGTC_1785 bathophenanthroline 24 µM 0.206856251143189 0.403705150297675 no 1335 0.418061062007648 1871 72812 An iron chelator. SGTC_1287 0971-0001 34.6 µM 0.206610682214136 0.403806198672273 no 1336 0.41815695853587 1949 4665869 SGTC_1094 duloxetine 25.4 µM 0.20618636471764 0.403980814851915 no 1337 0.418322669198583 1946 60834 A selective serotonin reuptake inhibitor. SGTC_528 3492-0019 172 µM 0.205914265864864 0.404092799712973 no 1338 0.418428940845976 2035 2869262 SGTC_3104 9120930 49.47 µM 0.204423306639354 0.404706557408597 no 1339 0.419011359327614 1958 17014836 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.203833339603745 0.404949483899674 no 1340 0.419241869254955 1934 65057 A dermal irritant. YDR527W RBA50 SGTC_2281 7943571 200 µM 0.203627850943726 0.405034105096796 no 1341 0.419322163603356 2107 1244024 SGTC_987 1497-1013 404 µM 0.202787118255253 0.405380368983234 no 1342 0.419650713447015 2004 1676435 SGTC_2996 9066192 71.4286 µM 0.201733312713846 0.405814493562511 no 1343 0.420062609097313 1878 6472854 SGTC_2701 st077767 14.721 µM 0.201652549130008 0.405847769626836 no 1344 0.42009418037004 1926 5721188 SGTC_1856 st057054 55.7 µM 0.200763386989097 0.406214165511138 no 1345 0.420441796472358 2067 1266018 SGTC_650 1328-0195 38 µM 0.199308403005152 0.406813895919646 no 1346 0.421010753196031 2055 2780821 SGTC_1009 4106-0057 9.87 µM 0.199249531363668 0.406838166855071 no 1347 0.421033777835393 2090 2928005 SGTC_194 1486-1323 56.904 µM 0.199143365664398 0.406881936554876 no 1348 0.421075299815495 1911 5178754 SGTC_2212 7123476 200 µM 0.198335991081982 0.407214836725284 no 1349 0.421391097079462 2038 1085715 SGTC_2828 7998861 71.43 µM 0.19756000777761 0.407534856688669 no 1350 0.421694663593287 2078 2988188 SGTC_646 4092-0839 27.3 µM 0.19722510668747 0.407672990896739 no 1351 0.421825692084062 2024 877796 SGTC_137 0438-0332 85.389 µM 0.18954414384479 0.410844219176308 no 1352 0.424833180157675 2045 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2305 7443522 69.23 µM 0.189400723678945 0.410903489005596 no 1353 0.424889378660094 1999 5415886 SGTC_2766 oltipraz 83.91 µM 0.18916099637735 0.411002563270726 no 1354 0.424983318058493 2052 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_817 1391-0715 46 µM 0.188351817815655 0.411337021684722 no 1355 0.425300433717298 1922 1353946 SGTC_298 1391-0729 10 µM 0.187934742131624 0.411509437092165 no 1356 0.425463903836214 1947 3237558 SGTC_2700 st077718 96.8 µM 0.18778491158278 0.411571379893102 no 1357 0.425522632081402 1919 904970 SGTC_1967 st070177 51.4 µM 0.184527798236531 0.412918474738935 no 1358 0.426799710868725 2050 5729214 SGTC_1591 genipin 88.4 µM 0.183226748678689 0.413456857660811 no 1359 0.427310053610505 2070 442424 A DNA cross-linking agent. SGTC_1441 4106-0040 13 µM 0.18255010904039 0.413736920021797 no 1360 0.427575516803642 2077 2904180 SGTC_157 1348-1695 65.819 µM 0.180531885769733 0.414572526381419 no 1361 0.428367512192911 2035 5380510 SGTC_2066 5222451 176 µM 0.179764141021574 0.4148904980126 no 1362 0.428668868138146 2056 2281147 SGTC_1065 prochlorperazine maleate 2.48 µM 0.179207036507517 0.415121265135074 no 1363 0.428887569417125 2048 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1841 st054148 70 µM 0.178359004200272 0.415472598282778 no 1364 0.42922052146753 1949 675442 SGTC_440 fluspirilene 35.1 µM 0.178027862708912 0.415609805975367 no 1365 0.429350546990653 2044 3396 An atypical antipsychotic. SGTC_2719 novobiocin 32.65 µM 0.174246505482256 0.417177328015881 no 1366 0.430835869216098 2079 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_19 0279-0214 38.434 µM 0.17227182968315 0.417996434404925 no 1367 0.431611914947863 2063 3566274 YBR002C RER2 SGTC_1975 st070967 30.8 µM 0.172099324807441 0.418068007328316 no 1368 0.431679721784834 2132 261391 SGTC_2838 9002687 71.43 µM 0.171954057786985 0.418128281267579 no 1369 0.431736823744957 1905 6457060 SGTC_2090 5301565 104.445 µM 0.171341412518807 0.418382500114464 no 1370 0.431977659711731 1994 2056344 SGTC_1911 st060208 74.3 µM 0.169963209966 0.418954513544617 no 1371 0.432519534911115 2066 688783 SGTC_2210 7115885 190.385 µM 0.168579981434306 0.419528785289339 no 1372 0.433063513840995 2021 2927039 SGTC_66 0109-0187 42.4 µM 0.166763107354755 0.420283352939715 no 1373 0.433778224097153 2038 759417 SGTC_428 3448-4153 16.5 µM 0.166303106017992 0.420474443122572 no 1374 0.433959210918052 1883 3834874 SGTC_2775 cyproheptadine 69.59 µM 0.166162128483148 0.420533010669752 no 1375 0.434014681086722 2127 2913 A selective serotonin reuptake inhibitor. SGTC_439 amiodarone 34.4 µM 0.165903711279302 0.420640371786876 no 1376 0.434116363396919 2055 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1082 camptothecin 424.86 nM 0.165612394556619 0.420761408302406 no 1377 0.434230996276068 1839 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1119 parthenolide 318.541 nM 0.165381076773181 0.420857521744714 no 1378 0.434322023564176 2039 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2046 4110841 106 µM 0.165377307122392 0.420859088088418 no 1379 0.434323507011565 2147 44119630 YMR134W ERG29 SGTC_1565 sinapyl alcohol 95.1 µM 0.164856482326886 0.421075510257892 no 1380 0.434528472857799 1964 5280507 A phenol propionate derived from cinnamic acid. SGTC_2006 4011487 200 µM 0.164671983737663 0.42115218204221 no 1381 0.434601084818495 2086 45595294 SGTC_2267 7931562 200 µM 0.164462379308344 0.421239290648584 no 1382 0.434683580205019 1866 934880 SGTC_1553 gossypol 38.6 µM 0.164141766355671 0.421372540268626 no 1383 0.434809771442963 2090 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2007 4011539 71.82 µM 0.163555152663958 0.42161636548399 no 1384 0.43504067607826 2022 45595301 SGTC_3142 9086498 49.47 µM 0.162943260581636 0.421870729654748 no 1385 0.435281554475592 2136 25236367 SGTC_2144 5628481 200 µM 0.162059593080313 0.422238128653778 no 1386 0.435629462775979 2005 2818399 SGTC_683 panaxydol 45 µM 0.161793286912001 0.42234886301836 no 1387 0.435734319830122 2084 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2611 pyromycin 23.93 µM 0.160102509293966 0.423052058236002 no 1388 0.436400162272082 1981 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1381 2324-0066 62.1 µM 0.159891120387336 0.42313999227467 no 1389 0.43648342171667 2032 10885928 SGTC_2625 euphol 100 µM 0.159884423036219 0.423142778316637 no 1390 0.436486059638733 2143 6708538 A triterpene alcohol. SGTC_1025 k007-0731 70 µM 0.157953357000286 0.423946245386039 no 1391 0.437246776470298 1924 6256118 SGTC_1508 1080-0625 72.9 µM 0.156334927346132 0.42461987621454 no 1392 0.437884513378341 2133 767111 SGTC_2871 9038510 12.99 µM 0.15623295387605 0.424662327514059 no 1393 0.437924701111893 2153 4945164 SGTC_100 0086-0128 49.5915 µM 0.155636408517265 0.424910685341607 no 1394 0.438159812388636 1921 93297 SGTC_1435 4092-0789 56.7 µM 0.153647741612276 0.425738835472345 no 1395 0.438943745748457 2139 2248285 SGTC_348 k064-0012 10.7 µM 0.153526734301337 0.425789237741968 no 1396 0.438991454645968 2083 5066323 SGTC_3204 9114183 49.47 µM 0.153386626238436 0.425847597419516 no 1397 0.439046695400763 1969 17027248 SGTC_2643 anethole 100 µM 0.153077573209885 0.425976334046834 no 1398 0.439168550703821 2051 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_660 4031-1742 102 µM 0.153009166484309 0.426004830065485 no 1399 0.439195523302232 2020 6738706 SGTC_1777 st045864 34.765 µM 0.151153297283782 0.426778071815438 no 1400 0.439927395139599 2142 4691462 SGTC_2085 5307070 144.047 µM 0.149833343965973 0.427328197460249 no 1401 0.440448050811982 2004 2840351 SGTC_656 4090-1979 187 µM 0.14912956760328 0.427621572814251 no 1402 0.440725697592699 2155 22330961 SGTC_3133 9127736 49.47 µM 0.148409871633694 0.427921625787695 no 1403 0.44100965495363 2184 27243420 SGTC_1425 4048-4433 7.33 µM 0.147799360693203 0.42817619043016 no 1404 0.441250556945219 2128 23734946 SGTC_1547 harmine 94.2 µM 0.146752425576756 0.428612800314849 no 1405 0.44166371844857 2123 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3105 9121040 49.47 µM 0.14655964153451 0.428693207789697 no 1406 0.441739805498567 2163 41448907 SGTC_591 4299-0174 154 µM 0.145703281756961 0.429050418970928 no 1407 0.4420778152764 2077 5509088 SGTC_916 4466-0038 42 nM 0.145702428698326 0.429050774834135 no 1408 0.442078152004268 2179 5722064 YGL116W CDC20 SGTC_232 clozapine 119 µM 0.145342399946226 0.429200970107585 no 1409 0.442220269900769 2104 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2857 9024691 58.44 µM 0.145157220370367 0.429278226534073 no 1410 0.442293370659518 2037 16478292 SGTC_2508 celastrol 40.54 µM 0.144999431841797 0.429344057626176 no 1411 0.442355660187108 2156 122724 Celastrol is a natural product and antioxidant. SGTC_1853 st056710 91.2 µM 0.144044524768732 0.429742497120416 no 1412 0.442732655275243 2191 269167 SGTC_25 0118-0223 35.662 µM 0.142917667652222 0.430212775617729 no 1413 0.443177602521026 2144 5333628 SGTC_1661 st013063 9.66 µM 0.141943526171228 0.430619400141211 no 1414 0.443562306726443 2113 721395 SGTC_351 caspofungin 25 nM 0.141193226251361 0.430932639270434 no 1415 0.443858648568856 2077 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2300 7976697 71.57 µM 0.140351355354152 0.431284159652483 no 1416 0.44419119506644 2017 2236109 SGTC_928 2764-0428 58.7 µM 0.140054383247784 0.431408172365714 no 1417 0.444308511079181 2072 662578 SGTC_261 5-fluorouridine 15.376 µM 0.138658715038697 0.431991080431957 no 1418 0.444859921747344 2150 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_193 1273-0060 1.558 µM 0.138357243074591 0.432117011254052 no 1419 0.444979043518479 2149 2847393 YHR072W ERG7 SGTC_1237 0330-0133 46.1 µM 0.136099207763659 0.433060455857972 no 1420 0.445871426907141 2071 X1237 YHR072W ERG7 SGTC_389 tpck 16.7 µM 0.135354251576414 0.433371794898884 no 1421 0.44616589656814 2062 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1225 1216-0074 20.6 µM 0.135197319908834 0.433437386525381 no 1422 0.446227933021454 2041 4241466 SGTC_1726 st035556 14.5795 µM 0.134769230444008 0.43361632138798 no 1423 0.446397167198829 2150 5919439 SGTC_2045 5106652 78.05 µM 0.134413361371383 0.433765079587493 no 1424 0.446537858332013 2144 673349 SGTC_182 3448-4371 550.524 µM 0.132095892929216 0.434734042043473 no 1425 0.447454222207085 2225 3491403 SGTC_3064 1327-0027 10 µM 0.131547681730195 0.434963313552587 no 1426 0.447671034848084 2112 16000455 YPR107C YTH1 SGTC_2028 5153890 36.43 µM 0.129604978291635 0.435775961650241 no 1427 0.448439482182507 2095 2830968 YPR165W RHO1 SGTC_1868 st057644 42.7 µM 0.128788205121584 0.436117705471933 no 1428 0.448762619375284 2169 688665 SGTC_1880 MG-132 525 µM 0.127512318829008 0.436651640913811 no 1429 0.449267461876975 2179 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3078 9116413 49.47 µM 0.127129971661959 0.436811668842733 no 1430 0.449418764980645 2157 17177322 SGTC_15 0266-0086 27.098 µM 0.126284868514848 0.437165415729185 no 1431 0.449753216769387 2180 1712902 YIL048W NEO1 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.125689377053812 0.437414709279933 no 1432 0.449988905530135 2162 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2879 9041815 71.43 µM 0.125575613114062 0.437462337673577 no 1433 0.450033934015694 2202 4942971 SGTC_2411 st077133 39.94 µM 0.125540992156865 0.437476832258117 no 1434 0.450047637336816 2180 1403142 YNL221C POP1 SGTC_540 1187-0821 17.3 µM 0.124363516257556 0.437969850086521 no 1435 0.450513729427929 1997 847520 SGTC_14 0354-0009 295 µM 0.124099452073273 0.438080428951954 no 1436 0.450618265994443 2128 1713507 SGTC_2372 9071633 200 µM 0.123284925834381 0.438421548369021 no 1437 0.450940738604643 2218 21321366 SGTC_906 1165-0455 526 µM 0.123173615051594 0.438468168313871 no 1438 0.450984809291914 2176 3252859 SGTC_476 mead acid 10 µM 0.123103916079333 0.438497360549819 no 1439 0.45101240514363 2140 5312531 An omega 9 fatty acid. SGTC_2102 5377816 72.7585 µM 0.122561732294671 0.438724456473441 no 1440 0.451227079559044 2185 1379702 SGTC_126 0417-1624 672.48 µM 0.122016053808541 0.438953036537225 no 1441 0.45144315208442 2211 41912 YDL195W SEC31 SGTC_2218 6965428 192.983 µM 0.121391755785418 0.439214574622196 no 1442 0.451690373260603 2161 675684 SGTC_2864 9034755 47.6 µM 0.1213677387061 0.439224636663221 no 1443 0.45169988436653 2219 4930451 SGTC_1604 st002052 72.4 µM 0.120230258468235 0.43970123292386 no 1444 0.45215037441733 2105 6254834 YHR062C RPP1 SGTC_1891 st059073 26.2 µM 0.12012580725918 0.439745001641449 no 1445 0.452191744589821 2219 688754 SGTC_1114 scopoletin 1.73284 µM 0.119463746534806 0.440022445396821 no 1446 0.452453980189446 2204 5280460 A coumarin with genotoxic properties. SGTC_1677 st019204 53.9 µM 0.117888281402806 0.440682779409034 no 1447 0.453078089291581 2009 3945625 SGTC_1291 0993-0025 5.79 µM 0.117654323752823 0.440780853574717 no 1448 0.453170779842977 2170 4353356 SGTC_2575 plumbagin 510 nM 0.117238017266983 0.440955376664135 no 1449 0.453335720605099 2074 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1888 azatryptophan 97.5 µM 0.11683006836918 0.441126407228895 no 1450 0.453497357898013 2078 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_571 k831-0106 44.2 µM 0.116321673527372 0.441339564625916 no 1451 0.453698804608567 2220 4783639 SGTC_1135 dihydrocapsaicin 536.708 nM 0.116004656423347 0.441472490671143 no 1452 0.453824425710702 2126 107982 A Capsaicinoid. SGTC_3028 9087778 49.47 µM 0.115986854662273 0.441479955188629 no 1453 0.453831479968294 2173 17217395 SGTC_1755 st041960 45.185 µM 0.115849223665171 0.44153766641538 no 1454 0.453886019137245 2114 2257073 SGTC_3092 9117248 49.47 µM 0.115674677124349 0.441610858798573 no 1455 0.453955188115198 2229 17141857 SGTC_1394 3474-0001 65.7 µM 0.115633967524039 0.441627929791318 no 1456 0.453971320640675 2116 5017666 YIL048W NEO1 SGTC_791 1348-1292 225 µM 0.115381901552633 0.441733632489655 no 1457 0.454071211808068 2166 5437054 SGTC_2159 5658611 73.75 µM 0.114828089748422 0.441965885469824 no 1458 0.454290691958944 2210 793844 SGTC_3072 9116419 49.47 µM 0.114431093196606 0.442132386858271 no 1459 0.454448033534687 2098 17170162 SGTC_483 fpl-64176 144 µM 0.114025275444836 0.442302598447783 no 1460 0.454608878602916 2189 3423 SGTC_39 0986-0283 58.349 µM 0.113841512942901 0.442379677210578 no 1461 0.45468171495918 2198 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1609 st001574 46.4 µM 0.11161561918031 0.443313495665819 no 1462 0.455564093548207 2182 3960012 SGTC_3158 9100007 49.47 µM 0.111356600249209 0.443422181180268 no 1463 0.455666786967695 2101 19297233 SGTC_1465 k213-0056 144 µM 0.110308017563411 0.443862214626135 no 1464 0.456082549486695 2074 24048857 YMR208W ERG12 SGTC_417 st075190 100 µM 0.106945053232342 0.44527393323389 no 1465 0.457416285404789 2227 222757 SGTC_1555 citronellol 128 µM 0.1067650093249 0.445349532523616 no 1466 0.457487703639009 2227 8842 A terpine precursor. SGTC_2904 7225135 42.03 µM 0.106211234763508 0.445582071379453 no 1467 0.457707378658285 2229 4446116 SGTC_2850 9015429 58.44 µM 0.105640000748103 0.445821961357688 no 1468 0.457933993149035 2151 6457570 SGTC_1707 st032323 6.317 µM 0.105232485499185 0.445993109694841 no 1469 0.458095667060089 2134 3132057 YMR211W DML1 SGTC_2536 dehydroabietamide 32.04 µM 0.104956564853113 0.44610899661933 no 1470 0.458205137257691 2201 3983547 SGTC_409 arachidonic acid 100 µM 0.104835330587524 0.446159916578417 no 1471 0.458253237376123 2225 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1937 st074714 47.2 µM 0.104821692012339 0.446165645011918 no 1472 0.458258648566746 2212 17250970 SGTC_3271 9137798 49.47 µM 0.104802188396924 0.446173836881572 no 1473 0.458266386762468 2214 6498326 SGTC_839 0122-0028 230 µM 0.10470496478631 0.446214672891269 no 1474 0.458304961145342 2143 759448 SGTC_3069 9117009 49.47 µM 0.103733322038144 0.446622815033715 no 1475 0.458690491066629 2227 41904981 SGTC_3234 9132280 49.47 µM 0.103406002886361 0.44676031941321 no 1476 0.458820374037267 2127 17612295 SGTC_814 3342-0569 96 µM 0.103120339402557 0.446880329783092 no 1477 0.458933731284328 2228 4346283 SGTC_1427 4048-4900 550 nM 0.103008399868019 0.446927358139337 no 1478 0.458978152144795 2234 24132586 SGTC_1997 st073024 93.8 µM 0.102941074222839 0.446955643540715 no 1479 0.459004869164116 2245 686268 SGTC_1503 4585-0012 61.3 µM 0.102306656554578 0.447222193518395 no 1480 0.459256635933745 2174 2922052 SGTC_2416 tofa 880 nM 0.102123641140259 0.447299091706054 no 1481 0.45932926809946 1953 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_794 k038-0031 316 µM 0.101814164868391 0.447429129873605 no 1482 0.45945209107033 2219 6624242 SGTC_1872 amphotericin b 148 nM 0.100873889689816 0.447824256684887 no 1483 0.459825285185392 2202 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_758 0868-0029 16 µM 0.100765494676836 0.44786981027766 no 1484 0.459868309320653 2253 762687 SGTC_490 phenamil 164 µM 0.100190833088459 0.448111326400771 no 1485 0.460096411765616 2229 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_750 4073-0104 132 µM 0.100029614131376 0.448179086219826 no 1486 0.460160407335488 2227 22330957 SGTC_554 4483-2211 187 µM 0.0957783387385792 0.449966423510346 no 1487 0.461848310718523 2145 747107 SGTC_1498 4478-3555 97.6 µM 0.0947131755274521 0.45041440395575 no 1488 0.462271326234475 2248 3437919 SGTC_2620 irigenin 100 µM 0.0941513354326724 0.450650725041248 no 1489 0.462494470838281 2193 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2325 6158266 200 µM 0.0939144326380443 0.450750376303493 no 1490 0.462588564461716 2149 3623240 SGTC_2888 9058547 12.99 µM 0.0933060605856612 0.451006297340567 no 1491 0.462830208719494 2198 16476514 SGTC_2639 lactacystin 53 µM 0.0927027277656578 0.451260118663429 no 1492 0.463069864951015 2210 3870 A proteasome inhibitor. SGTC_747 3448-8087 38.7 µM 0.0919641373550946 0.45157086979822 no 1493 0.463363266525474 2164 5168703 SGTC_230 MPP+ 141.667 µM 0.0912170741590962 0.451885215924096 no 1494 0.463660054147449 2122 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_734 2023-0417 80 µM 0.0903678126479957 0.452242601259419 no 1495 0.463997466899511 2209 3935732 SGTC_2239 6685329 187.64 µM 0.0900854353835602 0.452361439549816 no 1496 0.464109661518817 2102 805680 SGTC_2512 diallyl trisulfide 49.23 µM 0.0899490036005222 0.452418858307915 no 1497 0.464163869852134 2255 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1719 st032227 49.2 µM 0.0898331358085481 0.452467623274463 no 1498 0.464209908033449 2176 3125804 SGTC_2979 9012552 45.46 µM 0.089498911684268 0.45260829129884 no 1499 0.4643427092321 2278 17100905 SGTC_1782 st039423 80.636 µM 0.0891450097862505 0.452757247774971 no 1500 0.464483333561715 2064 2068169 SGTC_1648 st011736 69.8 µM 0.0887071917341998 0.452941533560885 no 1501 0.464657308446933 2225 2855514 SGTC_1089 terbinafine 2.25 µM 0.0886505463801987 0.452965377388524 no 1502 0.464679817992519 2234 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2207 7258803 200 µM 0.0874808625702386 0.453457772216011 no 1503 0.465144648281692 2231 3666799 SGTC_2127 5253358 187.912 µM 0.0850552946011779 0.454479076323558 no 1504 0.466108715598399 2198 20612 SGTC_2898 9056270 58.44 µM 0.0848554745467663 0.454563225611633 no 1505 0.466188145110654 2224 19154699 SGTC_2005 4024620 188 µM 0.0840135889740981 0.454917787309905 no 1506 0.466522813764034 2241 236743 SGTC_640 3381-0960 37.1 µM 0.0828921228845116 0.455390150614678 no 1507 0.466968658756916 2239 1745025 SGTC_1722 st034304 3.6505 µM 0.0825812415598202 0.455521105518459 no 1508 0.467092258693287 2200 4036148 YLR033W RSC58 SGTC_145 3737-0113 38.366 µM 0.0819710882799269 0.455778139060732 no 1509 0.467334852137193 2271 6849351 SGTC_2935 9038016 29.96 µM 0.0810608059611942 0.456161639518262 no 1510 0.467696797692005 2269 6463195 SGTC_438 sphingosine 6.67 µM 0.0798193497981183 0.456684728743002 no 1511 0.468190467256014 2194 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2872 9044037 25.97 µM 0.0793984189455244 0.456862105610729 no 1512 0.468357863085921 2179 6465195 SGTC_1361 1608-0041 5.61 µM 0.078075893524357 0.457419462924248 no 1513 0.468883841413773 2224 X1361 SGTC_56 0957-0365 83.25 µM 0.0771937519635076 0.457791274095008 no 1514 0.469234706013989 2266 6752360 SGTC_1360 1598-0022 39.8 µM 0.0770891181795403 0.457835378328322 no 1515 0.469276324837276 2235 761525 SGTC_2959 9079155 11 µM 0.0770863127583379 0.457836560849824 no 1516 0.469277440717909 2203 16189457 SGTC_731 3966-0296 387 µM 0.0769178529596574 0.457907569528325 no 1517 0.469344447506939 2252 660956 SGTC_2337 9009472 200 µM 0.0766881624736803 0.458004390150268 no 1518 0.469435810892547 2252 5742383 SGTC_177 1327-0068 8.361 µM 0.075665083233028 0.458435675331302 no 1519 0.469842777935471 2280 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1977 st070720 65.3 µM 0.0752744163736334 0.458600376224022 no 1520 0.4699981882475 2147 682188 SGTC_2220 6782180 200 µM 0.0749055447392328 0.458755895011512 no 1521 0.470144932444991 2272 833803 SGTC_1325 1431-0015 227 µM 0.0743992065302662 0.458969380916346 no 1522 0.470346370076163 2179 1103340 SGTC_2340 7987427 183.45 µM 0.0734372057967852 0.459375019033901 no 1523 0.470729105783177 2244 2239331 SGTC_3002 9075603 71.4286 µM 0.073087045083445 0.45952267864551 no 1524 0.470868425306254 2291 20105405 SGTC_1494 4358-1428 177 µM 0.0730472581418186 0.459539456793248 no 1525 0.470884255685341 2294 1564571 SGTC_2970 9090938 41.86 µM 0.0710329910335909 0.460388966479237 no 1526 0.471685749375167 2281 17217104 SGTC_385 1494-0393 12.4 µM 0.0709884398992445 0.460407757813289 no 1527 0.471703477951535 2216 3090647 SGTC_3283 9109332 35.8195 µM 0.0702406270758738 0.46072319281501 no 1528 0.472001069215617 2292 17027281 SGTC_115 0527-0192 112.043 µM 0.0696188976406341 0.460985463395436 no 1529 0.472248497646357 2138 4233931 SGTC_1902 st060212 70.5 µM 0.0690367105848603 0.461231068792113 no 1530 0.472480199186439 2297 688944 SGTC_2439 5492030 7.2 µM 0.0687842940500684 0.461337559551869 no 1531 0.47258066000378 2283 5722370 SGTC_2868 9035608 32.47 µM 0.0677738465667539 0.461763879913315 no 1532 0.472982831648029 2286 6462614 SGTC_3022 9087993 49.47 µM 0.0676620459378097 0.461811052697832 no 1533 0.473027331496876 2293 17173644 SGTC_1049 3226-0134 66 µM 0.0664489779733948 0.462322924948556 no 1534 0.473510188776328 2278 5702385 SGTC_3235 9132602 49.47 µM 0.0664216501204126 0.462334457068581 no 1535 0.473521066979511 2212 4912240 SGTC_1771 st048882 4.1505 µM 0.0658425357691441 0.462578845796852 no 1536 0.47375159552168 2234 4580403 SGTC_3020 9089140 49.47 µM 0.0657903586688679 0.46260086545099 no 1537 0.473772366137168 2227 17217859 SGTC_3191 9110352 49.47 µM 0.0657830221255505 0.462603961610515 no 1538 0.47377528666778 2293 17122424 SGTC_670 4204-0025 119 µM 0.0651524517882069 0.462870082621294 no 1539 0.474026309310532 2251 719039 SGTC_2428 5615643 7.78 µM 0.0640021375592704 0.463355595037477 no 1540 0.474484262386655 2249 2253075 SGTC_1471 k673-0312 37 µM 0.0633511430367022 0.463630384127067 no 1541 0.474743445631412 2300 24099884 SGTC_1839 st053978 48 µM 0.0620137193297593 0.464194973811312 no 1542 0.47527595329254 2305 3788398 SGTC_2568 diosmetin 100 µM 0.0615125467988423 0.464406561030147 no 1543 0.475475511214325 2309 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_402 epigallocatechin gallate 10 µM 0.0599004809689791 0.465087218022762 no 1544 0.476117448413379 2176 65064 An antioxidant. SGTC_1160 4092-0570 10.5 µM 0.0597612778641544 0.465145998089658 no 1545 0.476172883107829 2267 4994975 SGTC_2387 9077560 195.08 µM 0.0595342928157727 0.465241846693916 no 1546 0.476263276094621 2276 5303272 SGTC_1245 0418-0076 17.2 µM 0.0581270075702998 0.465836143522602 no 1547 0.476823730913986 2238 6790114 SGTC_1455 4262-0120 131 µM 0.0577253466699383 0.466005779032855 no 1548 0.476983701816644 2270 1529587 SGTC_1258 0671-0043 57.1 µM 0.0574508940913892 0.466121693553358 no 1549 0.477093011147214 2247 4298767 SGTC_1319 1306-0155 43.7 µM 0.0570037049543133 0.466310569180302 no 1550 0.477271121907782 2305 3122360 SGTC_1865 st057639 52.2 µM 0.056431471109733 0.466552269981227 no 1551 0.477499043286164 2297 688818 SGTC_1285 0929-0069 65.5 µM 0.0553745872011672 0.466998710208999 no 1552 0.477920020620622 2256 1206237 SGTC_2808 7946468 45.46 µM 0.0542619847584989 0.467468731453801 no 1553 0.478363218338501 2266 2970879 SGTC_768 0384-0033 77.3 µM 0.0537707368131441 0.46767627465726 no 1554 0.478558912209164 2194 3965305 YMR134W ERG29 SGTC_107 0358-0022 2.6945 µM 0.0530736486580091 0.467970796623588 no 1555 0.47883661358869 2273 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2487 5918373 44.05 µM 0.053045313094703 0.467982768861272 no 1556 0.478847901941645 2329 2876279 SGTC_344 k064-0035 6.43 µM 0.0530205325209834 0.467993239081608 no 1557 0.478857774067835 2247 5088750 SGTC_691 1548-0686 185 µM 0.0529066532825401 0.468041355311006 no 1558 0.478903141635003 2275 46495133 SGTC_2931 9014674 55.67 µM 0.0525629071689415 0.468186597667985 no 1559 0.479040085942203 2299 2996810 SGTC_1712 st032288 53.4 µM 0.0523247668416488 0.468287221107854 no 1560 0.479134959629246 2294 2883011 SGTC_2591 skatole 100 µM 0.0519199314833411 0.468458284250659 no 1561 0.479296246333346 2267 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_603 3794-0023 45.9 µM 0.0510469523421241 0.46882718128333 no 1562 0.479644053367026 2309 3802260 SGTC_49 0717-0965 32.132 µM 0.0510231889362876 0.46883722342226 no 1563 0.479653521256378 2274 5889349 YGL099W LSG1 SGTC_2224 6650123 117.647 µM 0.0509344305899544 0.468874731842404 no 1564 0.479688884731599 2306 2908370 SGTC_1670 st016595 4.04 µM 0.0508251466480173 0.468920914560504 no 1565 0.479732426320886 2317 597879 SGTC_2152 5568786 200 µM 0.0504268646504876 0.469089229604503 no 1566 0.479891114359697 2312 5399883 SGTC_272 doxorubicin 8.13 µM 0.049751847299664 0.469374506353525 no 1567 0.480160069707232 2311 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2329 6138490 200 µM 0.0495384420957316 0.46946469922849 no 1568 0.480245101215142 2205 720019 SGTC_202 3594-0513 34.79 µM 0.0491844070035224 0.469614330911525 no 1569 0.480386168817556 2318 708429 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.0475783963700997 0.470293159216571 no 1570 0.481026124863068 2324 165521 SGTC_1916 st067606 49.2 µM 0.0472839385290092 0.470417630031973 no 1571 0.481143464480601 2289 19590279 SGTC_2929 9013348 24.6 µM 0.0472432416315278 0.470434833319951 no 1572 0.481159682069761 2288 2995952 SGTC_805 3852-0218 479 µM 0.045196767810948 0.471299983951794 no 1573 0.481975235266355 2326 6615355 SGTC_3139 9095020 49.47 µM 0.0438003042609921 0.47189041952987 no 1574 0.482531792276678 2337 25236292 SGTC_826 1683-5028 118 µM 0.0436881510344159 0.471937841477963 no 1575 0.482576492152263 2272 722377 SGTC_567 1080-0542 68.4 µM 0.0418845021032013 0.472700535742544 no 1576 0.483295385543131 2338 5950415 SGTC_1610 st001799 48.1 µM 0.0418347300956674 0.47272158385621 no 1577 0.48331522431268 2306 621897 SGTC_852 0418-0143 439 µM 0.0413499966456119 0.472926577045556 no 1578 0.483508437784067 2334 5369229 SGTC_2946 9065502 71.43 µM 0.039735654076253 0.473609331966983 no 1579 0.48415193813541 2338 16489101 SGTC_2261 9010538 184.68 µM 0.0394987897712862 0.473709515707247 no 1580 0.484246359194004 2211 6457250 SGTC_3326 9140064 16.379 µM 0.0387092229234412 0.474043481588078 no 1581 0.484561110046193 2322 1868434 SGTC_104 0074-0074 590.992 µM 0.0387039145484961 0.474045726952192 no 1582 0.484563226195599 2350 3943124 SGTC_1168 k815-0004 80.5 µM 0.0379955728920111 0.474345352366851 no 1583 0.484845605900757 2327 642433 SGTC_2338 7999974 200 µM 0.0359485305403269 0.475211323274293 no 1584 0.485661699539069 2333 315925 SGTC_1949 st076024 69.1 µM 0.0358602440600647 0.475248674224152 no 1585 0.485696898053866 2330 2921930 SGTC_244 nsc-207895 1.295 µM 0.0356887240045185 0.475321239036405 no 1586 0.485765280883231 2332 42640 SGTC_3263 9137018 49.47 µM 0.0345893762101058 0.475786358304084 no 1587 0.486203586494133 2311 43844957 SGTC_1086 cerivastatin 2.18 µM 0.0344434866465321 0.475848084710187 no 1588 0.486261753349406 2359 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_479 n-linoleoylglycine 10 µM 0.0344033395179435 0.475865071208387 no 1589 0.486277760249767 2335 6433346 An anti-infammatory. SGTC_3226 9131256 49.47 µM 0.0337722756371044 0.476132083979785 no 1590 0.486529372083035 2336 17178073 SGTC_2059 5238311 157 µM 0.0335580407295117 0.47622273248584 no 1591 0.486614791027255 2328 703021 SGTC_2913 7966556 36.57 µM 0.0322427723919182 0.476779284408683 no 1592 0.487139223230247 2342 2976516 SGTC_525 k781-2675 26.7 µM 0.0319058238772666 0.476921870512173 no 1593 0.487273577111658 2347 3651118 YDL195W SEC31 SGTC_3175 9106517 49.47 µM 0.0314429770065159 0.47711773768702 no 1594 0.487458133693057 2315 41468073 SGTC_2429 5902844 64.44 µM 0.0310368324945408 0.477289614157498 no 1595 0.487620082864779 2342 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1371 2421-0008 32.7 µM 0.0307466074201329 0.477412437221298 no 1596 0.487735810684777 2327 2827552 SGTC_2923 7992654 58.14 µM 0.0303316065879463 0.477588069029745 no 1597 0.487901294875611 2338 2985126 SGTC_2343 7990716 14.84 µM 0.0302478919760408 0.47762349827942 no 1598 0.4879346768568 2332 6456862 SGTC_3062 9077494 49.47 µM 0.030092142958279 0.4776894140149 no 1599 0.487996783452978 2311 16459633 SGTC_3296 9122258 64.045 µM 0.0300529438173316 0.477706003879975 no 1600 0.488012414577993 2326 4730474 SGTC_2182 6325192 200 µM 0.0299726949792765 0.477739966923192 no 1601 0.488044414816775 2354 736248 SGTC_1150 3909-7983 10.9 µM 0.0298739028328134 0.47778177811742 no 1602 0.488083809539913 2334 23965914 SGTC_1195 1502-0147 41.1 µM 0.028372827333471 0.47841709891474 no 1603 0.488682398060136 2352 817940 SGTC_2167 5876490 200 µM 0.0275757863276914 0.478754463921051 no 1604 0.489000247015578 2326 686534 SGTC_881 0833-0569 170 µM 0.0241281377434737 0.480213928704951 no 1605 0.490375199589418 2342 5418700 SGTC_3340 9146634 11.102 µM 0.0236893364545968 0.480399702292628 no 1606 0.490550205948451 2328 4907387 SGTC_2309 7664088 163.95 µM 0.0232172110157981 0.480599588948743 no 1607 0.490738504951268 2365 704922 SGTC_1446 4239-0190 62 µM 0.0210835902720197 0.481502973211294 no 1608 0.491589487526167 2353 1340085 SGTC_2104 5389443 200 µM 0.0210056840144522 0.481535960883889 no 1609 0.491620560744646 2355 2244536 SGTC_728 3030-5151 22.5 µM 0.0210050273172733 0.481536238948246 no 1610 0.491620822671126 2365 3125388 SGTC_3118 9124250 49.47 µM 0.0198822707938983 0.482011659177722 no 1611 0.492068644103732 2294 1504786 SGTC_2692 st077426 47.7 µM 0.0183191399816028 0.482673594031445 no 1612 0.492692129265506 2370 25238571 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0174020938557453 0.483061955466281 no 1613 0.493057919376898 2362 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_870 0573-2213 57.6 µM 0.0168012379613805 0.48331642169605 no 1614 0.493297591143383 2375 3916321 SGTC_1289 0976-0073 69.1 µM 0.0163067271739473 0.483525855210546 no 1615 0.493494845373527 2363 3391136 SGTC_2010 4012422 159 µM 0.0160145079077408 0.483649617053366 no 1616 0.493611408771383 2372 952393 SGTC_3196 9111891 49.47 µM 0.015822380746475 0.483730988356802 no 1617 0.493688046708586 2383 18891510 SGTC_2594 a-mangostin 100 µM 0.0142085770525413 0.484414506424432 no 1618 0.494331788589921 2377 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_97 0535-0701 19.132 µM 0.0140497508995123 0.484481778914482 no 1619 0.494395144733218 2376 2832013 YGL099W LSG1 SGTC_799 1310-0557 151 µM 0.0137013140768564 0.484629364545644 no 1620 0.494534137532307 2327 5354492 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0127447420820732 0.485034545695808 no 1621 0.494915721169611 2379 676296 Flavone; oxidizing agent. SGTC_2022 5136654 200 µM 0.0118868320463111 0.485397949142308 no 1622 0.495257951789646 2372 1713771 SGTC_254 nsc-64875 3.808 µM 0.0118483018431352 0.485414270497823 no 1623 0.49527332203436 2381 56993 SGTC_1013 4112-3890 241 µM 0.0112499901022929 0.485667717871342 no 1624 0.495511997962924 2371 705171 SGTC_842 0271-0008 11.1 µM 0.0101782392009367 0.486121730474182 no 1625 0.495939540151102 2372 1221709 SGTC_1393 3470-5649 58.2 µM 0.00982865778031111 0.486269823255001 no 1626 0.496078995981746 2362 4108395 SGTC_1704 st028805 70.8 µM 0.00969371212862484 0.486326990636074 no 1627 0.496132828943037 2366 2876101 SGTC_2185 6113692 200 µM 0.00921082134777046 0.486531561220128 no 1628 0.496325465884664 2378 874150 SGTC_141 0443-0274 32.331 µM 0.00895960776850081 0.486637986086965 no 1629 0.496425681466544 2385 1627241 SGTC_1384 3089-0840 101 µM 0.00872499670806405 0.486737378272931 no 1630 0.496519274078885 2387 1069836 SGTC_1520 flindersine 88 µM 0.00835097278188466 0.486895833951224 no 1631 0.496668482597511 2391 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_843 0310-0051 143 µM 0.00807644978170917 0.48701213726253 no 1632 0.496777997734595 2384 2065037 SGTC_1833 st055984 71 µM 0.00659847009751503 0.487638310931707 no 1633 0.49736761039444 2393 676288 SGTC_81 0411-0046 9.971 µM 0.00622811584656403 0.487795223255578 no 1634 0.497515357324555 2396 12925265 SGTC_975 1335-0046 28.5 µM 0.00551811753793232 0.488096041817973 no 1635 0.497798600777862 2384 16486740 SGTC_3043 9092303 49.47 µM 0.00429981375097114 0.488612239569773 no 1636 0.498284627782635 2397 25236084 SGTC_1847 st056231 15 µM 0.0041854187154694 0.48866070996829 no 1637 0.498330264388213 2396 5393180 SGTC_53 0973-0023 39.979 µM 0.00418262123423034 0.488661895293074 no 1638 0.49833138041199 2398 674768 SGTC_467 ro 31-8220 72.8 µM 0.00390421205327531 0.488779860945308 no 1639 0.498442448697222 2395 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1192 1488-0095 21.4 µM 0.00276521809676133 0.489262477860523 no 1640 0.498896838992545 2392 915875 SGTC_1516 st013856 110 µM 0.00213495673996623 0.489529540330583 no 1641 0.499148276136631 2392 5281404 A mutagen and neurotoxin. SGTC_1953 st076800 12.1 µM 0.00176296820449205 0.489687166320725 no 1642 0.499296677808552 2397 297591 SGTC_1380 2291-0730 164 µM 0.00171471036461667 0.48970761516032 no 1643 0.499315929872133 2403 2999191 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.00132524562516531 0.489872648439208 no 1644 0.499471303642961 2404 688761 SGTC_1080 nisoldipine 24.4 µM 0.0011388844373309 0.489951618457069 no 1645 0.499545650943677 2401 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2393 9031399 185.94 µM 0.000887036062640539 0.490058339107459 no 1646 0.499646123856779 2401 1526623 YDL150W RPC53 SGTC_2636 apigenin dimethyl ether 100 µM -0.00160432112006179 0.491114087865376 no 1647 0.499359968748423 2412 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2729 fluphenazine 10.66 µM -0.00315864498917283 0.491772787164902 no 1648 0.49873988506041 2411 3372 An atypical antipsychotic. SGTC_2276 7947513 42.08 µM -0.00345652453059845 0.491899026693919 no 1649 0.498621048967351 2426 2105100 SGTC_1680 diphenhydramine 100 µM -0.00396580680908231 0.492114859283364 no 1650 0.498417876135129 2421 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1432 4049-0298 68.4 µM -0.00581066600264019 0.492896724982849 no 1651 0.497681892698963 2417 741646 SGTC_2781 5567276 71.43 µM -0.00586344689367891 0.492919094351549 no 1652 0.497660836528641 2420 2853274 SGTC_1092 toremifene 6.32 µM -0.00597099235402455 0.492964673871718 no 1653 0.497617932848575 2417 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1249 0481-0015 10.2 µM -0.00632988232846281 0.493116777957763 no 1654 0.497474759172532 2423 4227577 SGTC_744 1594-0068 283 µM -0.00952272460745577 0.494470003968938 no 1655 0.496201039945949 2428 668392 SGTC_733 4069-0007 56.1 µM -0.00987758449167234 0.494620408855752 no 1656 0.496059477995411 2423 5717425 YNL287W SEC21 SGTC_715 0868-0130 184 µM -0.0102448781081674 0.494776084498397 no 1657 0.495912956459549 2432 2876258 SGTC_812 4251-0442 148 µM -0.0104022242275739 0.494842775143333 no 1658 0.495850187784822 2418 5723007 SGTC_2753 fluvastatin 17.09 µM -0.0107521551150045 0.494991092734703 no 1659 0.495710593368237 2440 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_665 3914-0008 307 µM -0.0115494206552992 0.495329014885379 no 1660 0.495392550217297 2430 1069549 SGTC_487 nimodipine 119 µM -0.0118790470907022 0.495468728519268 no 1661 0.495261057318325 2420 4497 L-type voltage-gated calcium channels inhibitor SGTC_1265 0819-1001 68.8 µM -0.0129696878667054 0.495931005341306 no 1662 0.494825988202607 2429 3106768 SGTC_776 4476-4378 112 µM -0.0130083932080749 0.495947411014092 no 1663 0.494810548307985 2475 2892008 SGTC_282 k297-0036 65.7 µM -0.0137542848925865 0.496263566485506 no 1664 0.494513007225411 2422 5061378 SGTC_1121 fusaric acid 630.51 nM -0.0138160226273075 0.496289734900434 no 1665 0.494488379772833 2446 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_360 0957-0399 1.01 µM -0.0155543573351751 0.497026558868429 no 1666 0.49379495942142 2443 6752301 YPR165W RHO1 SGTC_3244 9134489 49.47 µM -0.0164388843996093 0.497401485389702 no 1667 0.493442129334823 2467 16584271 SGTC_1734 st037168 69.4 µM -0.0165267363114274 0.497438723512356 no 1668 0.493407086253425 2476 708907 SGTC_1615 st002656 86.5 µM -0.0166147188633405 0.497476017032287 no 1669 0.493371991112241 2437 1584458 SGTC_2976 9009005 19.48 µM -0.0179003317607478 0.49802095731517 no 1670 0.49285918217517 2434 2993148 SGTC_419 nsc-638432 893 µM -0.0184237920988637 0.498242840635818 no 1671 0.492650386156185 2453 368090 SGTC_1487 3970-0795 2.82 µM -0.018931740579857 0.498458149341794 no 1672 0.492447779376706 2456 3765103 SGTC_3018 9082602 49.47 µM -0.01914190264698 0.49854723276846 no 1673 0.492363952033463 2427 17332089 SGTC_2378 9074213 121.43 µM -0.0201268133176398 0.498964717266358 no 1674 0.49197110527048 2439 657714 SGTC_1178 0988-0033 191 µM -0.0211792414414716 0.499410822342353 no 1675 0.49155133674933 2478 5392207 SGTC_2262 9014885 67.46 µM -0.0221560772029046 0.499824885866604 no 1676 0.49116172714772 2482 6457424 SGTC_1624 st003710 6.25 µM -0.0223323895182587 0.499899621593794 no 1677 0.491091406110446 2439 24207033 SGTC_2507 purpurin 79.67 µM -0.0225691965847184 0.5 no 1678 0.49099695756539 2440 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2023 5144124 124 µM -0.0227639441390608 0.499917449890848 no 1679 0.490919284487825 2452 2830192 SGTC_2743 auranofin 4.32 µM -0.0236826343626146 0.49952803315233 no 1680 0.490552878946395 2457 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1003 4049-0218 100 µM -0.0245129193165439 0.499176090240013 no 1681 0.490221739343815 2473 295161 SGTC_1851 st056236 18.9 µM -0.0245699212868178 0.499151928146757 no 1682 0.490199005694866 2451 5393171 SGTC_2384 9036245 200 µM -0.0256279029165624 0.498703469731707 no 1683 0.489777065033375 2518 6462766 SGTC_1125 tnp00248 1.32998 µM -0.0260826083018543 0.498510729183942 no 1684 0.489595724454315 2464 24207736 SGTC_1983 st071813 46.9 µM -0.0270167132201539 0.498114781871666 no 1685 0.489223201837459 2501 11838595 SGTC_810 3825-7150 143 µM -0.027507028443962 0.497906948340246 no 1686 0.489027667041087 2456 22330411 YGL099W LSG1 SGTC_2471 5466956 24.79 µM -0.0277918385001646 0.497786224057623 no 1687 0.488914087691672 2512 724419 SGTC_1046 2001-0062 216 µM -0.028914827521257 0.497310217511296 no 1688 0.488466259957367 2468 739778 SGTC_2582 agaric acid 100 µM -0.0290394282224779 0.497257402659861 no 1689 0.488416572334595 2449 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_884 0851-0618 334 µM -0.0294060567480253 0.497101999072673 no 1690 0.488270371154315 2461 9642473 SGTC_1786 berberine 21.6 µM -0.0295585091723662 0.497037378878109 no 1691 0.488209577863213 2456 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1614 st002383 48.6 µM -0.0297519340366639 0.496955391757673 no 1692 0.488132446430273 2450 1947235 SGTC_2880 9042983 58.44 µM -0.0299903681010042 0.496854326736275 no 1693 0.488037367429424 2492 6464714 SGTC_2143 5623677 140.463 µM -0.0300818826273565 0.496815536537021 no 1694 0.488000874880537 2451 5375313 SGTC_1102 cgs 12066b 26.1 µM -0.0305107432421988 0.496633756090733 no 1695 0.487829862751358 2504 6438352 A 5-HT1B full agonist. SGTC_1113 artemisinin 1.17947 µM -0.030519381501865 0.496630094612813 no 1696 0.487826418188457 2462 2240 An anti-malaria and mitochondrial poison. SGTC_1919 st067113 52.3 µM -0.0309429524541722 0.496450556987309 no 1697 0.487657517602174 2495 1268243 SGTC_281 1672-3440 14.9 µM -0.0317328558387222 0.496115745187833 no 1698 0.487342546451759 2472 6833000 SGTC_3047 9092122 49.47 µM -0.032354369822211 0.495852309545722 no 1699 0.487094725512954 2472 17173831 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0324746052265004 0.495801346632222 no 1700 0.487046783719425 2555 61125 An anti-inflammatory. SGTC_2408 sulbentine 18.36 µM -0.0325043823679255 0.4957887253197 no 1701 0.487034910626799 2575 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1960 st011366 51.8 µM -0.0345400261496862 0.494925909834435 no 1702 0.486223262562579 2472 3972846 SGTC_3319 9138450 16.7555 µM -0.0347711648171147 0.494827942242014 no 1703 0.486131106932261 2489 2029690 SGTC_643 k048-0106 28.4 µM -0.0351596068556058 0.49466330268328 no 1704 0.485976235680645 2533 6763920 SGTC_1556 plumbagin 1.48 µM -0.0363274705042009 0.49416831407195 no 1705 0.48551062304842 2484 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3286 9117135 37.221 µM -0.0363811306121116 0.494145570922815 no 1706 0.485489229904244 2486 3438150 SGTC_378 3970-0959 8.33 µM -0.0366840227837338 0.494017194316164 no 1707 0.485368474020097 2521 6615653 SGTC_633 0437-0093 97.7 µM -0.0367095783984436 0.49400636295479 no 1708 0.485358285667297 2460 2831118 SGTC_2192 5915882 198.485 µM -0.0367663357435743 0.493982307226976 no 1709 0.485335658037759 2466 2876149 SGTC_2992 9074591 71.4286 µM -0.0371495406518951 0.493819892297258 no 1710 0.485182885769338 2462 17741321 SGTC_2933 9026794 32.47 µM -0.0377332945563076 0.493572480039951 no 1711 0.484950164837056 2507 17586027 SGTC_1514 1189-1591 158 µM -0.0380310848097934 0.493446268624812 no 1712 0.484831448927499 2477 767698 YMR146C TIF34 SGTC_712 r015-0009 80.6 µM -0.0389164439990166 0.493071033819851 no 1713 0.484478503042426 2489 6813872 YLR060W FRS1 SGTC_600 1495-0418 41.6 µM -0.0389582830927254 0.493053301635729 no 1714 0.484461824307234 2483 5377768 SGTC_2148 5546263 113.568 µM -0.0401165250101053 0.492562422796751 no 1715 0.484000113676801 2491 792097 SGTC_557 1315-0110 16.2 µM -0.0408224112909335 0.492263263968252 no 1716 0.483718736311237 2487 6833801 SGTC_802 4112-3352 742 µM -0.0414562656512536 0.491994636401819 no 1717 0.483466078906406 2607 704594 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0415578322026771 0.491951592817453 no 1718 0.483425594603699 2476 688662 SGTC_3012 9080433 71.4286 µM -0.0425616806826326 0.491526170116118 no 1719 0.483025471089153 2481 17688859 SGTC_2587 piperic acid 92.2 µM -0.0427776451438971 0.491434647403069 no 1720 0.482939392132321 2509 5370536 SGTC_2749 bexarotene 57.39 µM -0.0430507052430223 0.491318929004722 no 1721 0.482830557176847 2511 82146 An retinoic acid receptor inhibitor. SGTC_1605 st000082 49.1 µM -0.0432042448599824 0.491253861749726 no 1722 0.482769360670569 2598 1114022 SGTC_379 3970-0972 5.9 µM -0.0440693576697892 0.490887247312719 no 1723 0.48242455904102 2504 2898042 YBL034C STU1 SGTC_2767 sibutramine 71.45 µM -0.046531281795677 0.489843985009902 no 1724 0.48144340090686 2511 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3169 9102970 49.47 µM -0.0465742169779279 0.489825791439221 no 1725 0.481426290797553 2496 17027839 SGTC_2055 5235184 200 µM -0.0473103569193854 0.48951385911217 no 1726 0.48113293684955 2532 2836034 SGTC_2238 6671620 73.2395 µM -0.0484768178017115 0.489019595572082 no 1727 0.480668119715073 2476 729941 SGTC_167 3672-0051 66.205 µM -0.048837408097653 0.48886680631006 no 1728 0.480524435189217 2486 3237971 SGTC_1831 st055328 12 µM -0.0495516627203445 0.488564167301523 no 1729 0.480239833418442 2501 1103068 SGTC_2665 lovastatin 100 µM -0.0504837411138436 0.488169243446982 no 1730 0.479868452797269 2508 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2362 9071156 126 µM -0.0511770396747953 0.487875498682868 no 1731 0.4795922237749 2537 653133 SGTC_1271 0832-2808 169 µM -0.05221063359685 0.487437585899214 no 1732 0.479180430053122 2527 3663794 SGTC_3054 9094397 49.47 µM -0.0530020523366294 0.487102288039812 no 1733 0.478865136242871 2515 2598354 SGTC_2735 sertaconazole 140 nM -0.0536344754647014 0.486834357887418 no 1734 0.478613194291792 2497 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2233 sulbentine 40.3845 µM -0.0549206768565459 0.486289468802218 no 1735 0.478100829494386 2487 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1032 k061-1018 98.7 µM -0.0549469049482468 0.486278357740674 no 1736 0.478090381775724 2692 4005393 SGTC_371 0195-0006 7.36 µM -0.0551326259935487 0.486199680649663 no 1737 0.478016401939768 2484 3928593 SGTC_3146 9095609 49.47 µM -0.0555067125314941 0.486041207833028 no 1738 0.477867391184908 2552 17173999 SGTC_156 3474-0145 5.642 µM -0.056503979406258 0.485618750407456 no 1739 0.47747016274204 2483 2265471 SGTC_415 dibenzyl ketone 100 µM -0.0569560718257322 0.485427242466558 no 1740 0.477290093953364 2602 7593 SGTC_131 0141-0277 33.849 µM -0.0574796178044395 0.485205470749102 no 1741 0.477081570948462 2566 1547771 SGTC_1148 3909-7663 27.7 µM -0.05758034172184 0.485162805074308 no 1742 0.477041454361046 2633 4084526 SGTC_304 1310-0298 97 µM -0.0583967824118962 0.484816975025356 no 1743 0.476716288831947 2526 1550234 SGTC_2044 5102272 200 µM -0.0586240716075195 0.484720701303879 no 1744 0.4766257686414 2564 592666 SGTC_2352 9027995 87.8 µM -0.0602726236491335 0.48402244505354 no 1745 0.475969252728775 2561 2997347 SGTC_565 1418-0001 44.5 µM -0.0605769758010884 0.483893539772156 no 1746 0.475848055245264 2576 2862145 SGTC_2974 9094440 9.66 µM -0.0605778618799161 0.483893164484865 no 1747 0.475847702398957 2727 25236134 SGTC_532 1548-0774 215 µM -0.0609823247440888 0.483721860935871 no 1748 0.475686642832319 2666 5932993 SGTC_626 0214-0009 33 µM -0.0612111728294179 0.48362493744756 no 1749 0.475595515894205 2577 3437874 SGTC_1674 st016616 23.6 µM -0.0626011154017272 0.483036279351057 no 1750 0.475042070599716 2505 625830 SGTC_1735 st034310 56.75 µM -0.0638533878451451 0.482505957907125 no 1751 0.474543483801222 2738 871153 SGTC_1091 telmisartan 47.6 µM -0.0641622367920647 0.482375169030323 no 1752 0.474420523041813 2614 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1315 1237-0019 3.69 µM -0.0646337974283746 0.482175479974937 no 1753 0.474232787251807 2519 825140 SGTC_644 1498-1197 63.3 µM -0.0649721363198447 0.482032208313645 no 1754 0.474098092680507 2576 6741615 SGTC_2551 apiole 73.87 µM -0.0654276065994074 0.481839340321596 no 1755 0.473916772138881 2513 10659 A possible DNA adduct former. SGTC_778 3456-2434 196 µM -0.0655860358448046 0.481772254763969 no 1756 0.473853703478118 2678 5539063 SGTC_2634 4'-methoxyflavone 100 µM -0.0657551210664653 0.481700657590492 no 1757 0.473786393532157 2548 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_990 3985-0011 41.3 µM -0.0658082081207853 0.481678178615491 no 1758 0.473765260634576 2583 5399565 YGL099W LSG1 SGTC_1053 3366-3204 134 µM -0.0660879666430753 0.481559719723163 no 1759 0.473653895567299 2559 3632071 YPR165W RHO1 SGTC_2689 tacrolimus 100 µM -0.0672936153706731 0.481049227447794 no 1760 0.473173979782628 2605 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2063 5246145 200 µM -0.0675008936980228 0.480961465368947 no 1761 0.473091475290924 2584 711240 SGTC_3245 9134821 49.47 µM -0.067887574764208 0.48079774626356 no 1762 0.472937564917723 2523 17014901 SGTC_1596 piperlongumine 63 µM -0.0691057149466834 0.480282012235663 no 1763 0.472452736018265 2539 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_163 TUB2.036 7.546 µM -0.0693845721906799 0.480163954762103 no 1764 0.472341754465164 2524 15992207 YJR013W GPI14 SGTC_1307 1187-1599 12.2 µM -0.0695049846930624 0.480112977259088 no 1765 0.472293832519973 2539 1538471 SGTC_2259 7964009 200 µM -0.0695305896681252 0.480102137249775 no 1766 0.472283642265942 2678 313134 SGTC_993 3909-8757 62.7 µM -0.070299065140964 0.4797768057472 no 1767 0.471977813288763 2575 4288324 YLR208W SEC13 SGTC_2712 st079126 47.7 µM -0.0710823287084803 0.479445227618603 no 1768 0.471666116119288 2524 3152970 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0716752884635806 0.47919422004694 no 1769 0.471430161259382 2532 1241132 A phosphatase inhibitor. SGTC_3099 9120367 49.47 µM -0.0719024472558478 0.479098062958071 no 1770 0.471339771232228 2542 24824940 SGTC_920 mycophenolic acid 780.421 nM -0.0720697819953689 0.479027230371891 no 1771 0.471273187073003 2559 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1957 st077035 62.4 µM -0.0725599133765033 0.478819762190245 no 1772 0.47107816354296 2545 705593 SGTC_2635 hydroquinidine 100 µM -0.0729706672973891 0.478645898187345 no 1773 0.470914729685231 2550 442912 An experimental heart treatment. SGTC_793 0488-0545 106 µM -0.0756722055253038 0.477502493318842 no 1774 0.469839944674833 2538 292548 SGTC_134 0269-0018 6.916 µM -0.0760990257357607 0.477321861709475 no 1775 0.469670157622641 2613 4378915 SGTC_708 3448-5400 146 µM -0.0774862130286283 0.476734832203533 no 1776 0.469118379353299 2544 3462195 SGTC_3261 9137475 49.47 µM -0.0795065353947835 0.475879963436475 no 1777 0.468314866788807 2537 17027690 SGTC_2335 9018011 154.17 µM -0.0811610618604938 0.475179958160553 no 1778 0.46765693272633 2647 6458208 SGTC_3172 9105863 49.47 µM -0.0813677846477504 0.475092502196289 no 1779 0.467574734130831 2540 2348785 SGTC_1266 0828-0227 32.9 µM -0.082543899459097 0.474594959038915 no 1780 0.467107105348082 2635 3913820 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0833136326892752 0.47426935279081 no 1781 0.466801080331343 2593 4330530 SGTC_3109 9122853 49.47 µM -0.0837245261673959 0.474095547018557 no 1782 0.466637728271972 2618 1234709 SGTC_2697 mebhydrolin 72.4 µM -0.0837412505960168 0.474088472777737 no 1783 0.466631079538968 2607 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2894 9048625 32.47 µM -0.0845798096582867 0.47373378246765 no 1784 0.466297725549406 2594 4092861 SGTC_2431 5490079 200 µM -0.0859801999398856 0.473141497627176 no 1785 0.465741078544611 2596 5722345 SGTC_1308 1187-1617 41.4 µM -0.0887233567271161 0.471981472773531 no 1786 0.464650884875636 2547 2882570 SGTC_464 bw-b 70c 158 µM -0.0894952306966184 0.471655105488114 no 1787 0.46434417186432 2690 5353454 SGTC_1606 st000094 49.2 µM -0.0912113767664839 0.470929545270635 no 1788 0.463662317642459 2562 1242210 SGTC_1472 k841-0093 193 µM -0.0926775305934491 0.470309754270427 no 1789 0.463079874079359 2665 X1472 SGTC_2565 isoliquiritigenin 100 µM -0.0930071208270219 0.470170435585929 no 1790 0.462948952072288 2705 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1914 st062367 72.6 µM -0.0935385513601474 0.469945806157579 no 1791 0.462737862188196 2607 978205 SGTC_3287 9117173 37.0625 µM -0.0939334145110366 0.469778908342808 no 1792 0.462581025118393 2565 2789709 SGTC_2336 9001819 198.65 µM -0.0939421922062119 0.469775198312224 no 1793 0.462577538741087 2684 2989602 SGTC_2100 5377183 190 µM -0.0942937738522794 0.46962659897421 no 1794 0.462437897813125 2658 2844202 SGTC_2557 derrustone 83.84 µM -0.0949715035997259 0.469340161983604 no 1795 0.462168730710641 2685 629853 An antioxidant. SGTC_2193 5925765 200 µM -0.0958854315312566 0.468953922895559 no 1796 0.461805782608435 2658 877370 SGTC_692 k241-0027 77.8 µM -0.0960994339505171 0.46886348660356 no 1797 0.461720800434911 2668 3600480 SGTC_103 0844-0104 51.839 µM -0.096399558962291 0.468736658066375 no 1798 0.461601621195426 2692 5375804 SGTC_2285 7945142 200 µM -0.0971963446260619 0.468399963267979 no 1799 0.461285235434114 2666 2970608 SGTC_1500 4488-1866 171 µM -0.0980194291582414 0.468052179188362 no 1800 0.460958432710646 2711 2900003 SGTC_1212 0520-0165 585 µM -0.0983716815872865 0.467903346762816 no 1801 0.460818580206605 2872 5403258 SGTC_2137 5261020 140 µM -0.0997773729045567 0.467309464018329 no 1802 0.460260536098626 2583 763655 SGTC_1066 ketoconazole 628 nM -0.100011584067204 0.467210520476539 no 1803 0.460167564400648 2703 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1510 1123-0200 71.5 µM -0.100461017477957 0.467020661023156 no 1804 0.459989164885439 2757 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_477 mead ethanolamide 10 µM -0.10046320474792 0.467019737047236 no 1805 0.45998829668327 2569 16061185 SGTC_1867 st057372 64 µM -0.100672814754396 0.466931191601637 no 1806 0.459905096196799 2573 688837 SGTC_2328 6201408 200 µM -0.101552613031043 0.466559556775594 no 1807 0.459555897114996 2659 2890418 SGTC_2845 9003024 42.97 µM -0.102617560220225 0.466109752390199 no 1808 0.459133252688237 2759 2990173 SGTC_9 0092-0002 10.449 µM -0.102862096321336 0.466006473160975 no 1809 0.459036210416081 2606 759368 SGTC_1132 3456-3614 2.5 µM -0.103185657735099 0.465869821302306 no 1810 0.458907811308567 2787 3125502 SGTC_790 1575-0012 79.1 µM -0.103313631395012 0.46581577443915 no 1811 0.458857028611767 2575 378741 YLR208W SEC13 SGTC_478 N-arachidonylglycine 10 µM -0.103722405390748 0.465643141952683 no 1812 0.458694822812395 2596 5283389 SGTC_2293 7624732 200 µM -0.104052865939888 0.465503587343816 no 1813 0.45856369763405 2586 894453 SGTC_2971 9092186 9.93 µM -0.105878799769179 0.464732566248389 no 1814 0.457839257419463 2604 25236400 SGTC_2462 5162487 171.77 µM -0.106042363124708 0.464663506200448 no 1815 0.457774370370235 2568 2259986 SGTC_1350 1495-0454 146 µM -0.106204887950245 0.464594885697058 no 1816 0.457709896429897 2706 1069057 SGTC_368 fentichlor 4.58 µM -0.106750280781638 0.464364620087766 no 1817 0.457493546088831 2674 7329 A pesticide. SGTC_2133 5320837 200 µM -0.109111947944588 0.463367659653525 no 1818 0.456556849191395 2693 2841355 SGTC_2037 5169046 200 µM -0.109281113734399 0.463296256312718 no 1819 0.456489762964316 2702 5718022 SGTC_2162 5663267 200 µM -0.10995994254224 0.463009740764593 no 1820 0.456220571715385 2602 6456493 SGTC_3203 9113543 49.47 µM -0.110144166417074 0.462931988080907 no 1821 0.4561475207417 2758 17018012 SGTC_1207 2099-0101 141 µM -0.111112145608973 0.462523470560749 no 1822 0.455763708789491 2681 5837381 SGTC_142 0335-0849 62.6745 µM -0.112741247849136 0.461836027877427 no 1823 0.455117849324255 2606 3889043 YPR107C YTH1 SGTC_542 3381-0244 89.3 µM -0.113044576256483 0.461708042978517 no 1824 0.454997607474472 2760 1112843 SGTC_1608 st001473 40.5 µM -0.11399938437767 0.461305201874717 no 1825 0.454619140729352 2606 7292267 SGTC_1042 0350-0096 82 µM -0.117220117981967 0.459946644085815 no 1826 0.453342812488225 2587 3122515 SGTC_2849 9019321 12.99 µM -0.117786557707532 0.459707758491938 no 1827 0.453118390397287 2712 16489627 SGTC_2603 homopterocarpin 100 µM -0.118372053611751 0.459460851591623 no 1828 0.452886434030645 2711 101795 A weak amylase inhibitor. SGTC_319 1348-1596 45.5 µM -0.118671324155759 0.459334653560204 no 1829 0.452767877990491 2780 5380505 SGTC_3219 9131112 49.47 µM -0.118686849134081 0.459328107014553 no 1830 0.45276172788438 2622 17612988 YMR079W SEC14 SGTC_829 1635-0120 117 µM -0.12027890977745 0.458656828543675 no 1831 0.452131105185784 2755 285054 SGTC_2793 7325131 81.82 µM -0.123402474419702 0.457340149062372 no 1832 0.450894198873904 2704 4176441 SGTC_2369 9071472 200 µM -0.124134753716535 0.45703153780462 no 1833 0.450604290736822 2758 17296037 SGTC_3170 9103054 49.47 µM -0.124906480196842 0.456706330000489 no 1834 0.450298794048773 2688 16432970 SGTC_1563 conessine 56.1 µM -0.125359037064447 0.45651563468097 no 1835 0.45011965796093 2720 441082 An anti-amoebic, histamine inhibitor. SGTC_1309 pyrazolanthrone 13.4 µM -0.127213023990009 0.45573451936005 no 1836 0.449385898739066 2700 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1269 0831-0796 3.05 µM -0.127389066074609 0.455660358767239 no 1837 0.449316234872407 2713 927758 SGTC_3282 9108498 15.4605 µM -0.127720685886885 0.45552066272319 no 1838 0.44918500959671 2727 16459645 SGTC_1151 3909-8316 15.3 µM -0.127960869721854 0.455419487847811 no 1839 0.4490899699212 2735 800431 SGTC_416 estradiol valerate 100 µM -0.128442241014527 0.45521672404227 no 1840 0.44889950223985 2703 13791 A steroid. SGTC_1904 st060225 78 µM -0.129670818536519 0.454699274118623 no 1841 0.448413435517167 2624 66595 SGTC_785 1270-0111 65.3 µM -0.129731544752616 0.454673699553716 no 1842 0.448389412179291 2627 6741994 SGTC_1803 st050068 52.4 µM -0.129811565420313 0.454639999506733 no 1843 0.448357756230519 2628 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1940 st075990 51.1 µM -0.131555982157349 0.453905434275111 no 1844 0.447667751986414 2898 1084979 SGTC_1376 2910-0861 41.3 µM -0.132930457529791 0.453326760434016 no 1845 0.447124189513871 2649 1112859 SGTC_1120 ficusin 1.78878 µM -0.133899205709937 0.452918963017708 no 1846 0.446741139191004 2790 6199 A DNA cross-linker. SGTC_1628 st004252 77.7 µM -0.133946713545146 0.452898965727375 no 1847 0.446722355510467 2784 692968 SGTC_1005 4092-0690 4.4 µM -0.13545206632174 0.452265385500227 no 1848 0.446127230214977 2702 1529343 SGTC_3343 9148379 18.9835 µM -0.13555648239883 0.452221442840821 no 1849 0.446085954908258 2757 1955036 SGTC_2322 7413319 38.22 µM -0.136048783950165 0.452014269618296 no 1850 0.445891357720695 2754 1840400 SGTC_3132 9126706 49.47 µM -0.136193116300887 0.45195353330739 no 1851 0.445834308430136 2868 850858 SGTC_2456 5770359 74.46 µM -0.137538590602641 0.451387400284453 no 1852 0.445302545839019 2802 3118787 SGTC_2403 6032726 181.2 µM -0.137871484601757 0.451247344231736 no 1853 0.445170993571812 2712 2881040 SGTC_2811 7967822 32.47 µM -0.13853073171264 0.450970001952203 no 1854 0.44491049168123 2754 2232244 SGTC_315 k915-0449 187 µM -0.138539075427922 0.450966491942 no 1855 0.444907194809357 2682 20970215 YNL149C PGA2 SGTC_1807 st050092 58.9 µM -0.139457401516561 0.450580196652986 no 1856 0.444544357800827 2669 5008496 SGTC_1760 st045453 10.4495 µM -0.140304449315226 0.450223926178979 no 1857 0.444209724527136 2686 3323419 YIL048W NEO1 SGTC_823 0417-1665 178 µM -0.1404403537142 0.450166768167109 no 1858 0.44415603806058 2745 3429856 SGTC_1257 0669-0121 16 µM -0.141103130569589 0.449888035531422 no 1859 0.443894235280464 2755 4307855 SGTC_1936 st074407 74.3 µM -0.141884394343242 0.449559504649701 no 1860 0.443585660556636 2646 809813 SGTC_1781 st038725 66.3 µM -0.14196709839405 0.449524728614067 no 1861 0.443552997045399 2641 4270275 YIL048W NEO1 SGTC_749 1000-0129 128 µM -0.143524681117763 0.448869856942666 no 1862 0.442937910159546 2805 708470 SGTC_893 0958-0369 48.9 µM -0.143538208615309 0.448864170035255 no 1863 0.442932568772861 2807 6819948 SGTC_2247 cerulenin 830 nM -0.143549442991674 0.448859447155064 no 1864 0.442928132842159 2886 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_372 0155-0182 15.9 µM -0.144340604593954 0.448526864717146 no 1865 0.442615758087279 2671 771486 SGTC_1574 spiramycin 23.7 µM -0.146075596856088 0.447797648952247 no 1866 0.441930855321606 2636 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2829 7992743 58.44 µM -0.14611559083099 0.44778084158925 no 1867 0.441915069402912 2822 16462845 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.146801793117252 0.447492481508555 no 1868 0.441644234658527 2783 6708760 SGTC_1946 st076057 65.1 µM -0.146975131040682 0.447419644780964 no 1869 0.44157582484005 2660 953009 SGTC_3336 9143619 71.43 µM -0.147819417088315 0.44706490053669 no 1870 0.441242642530695 2655 45595730 SGTC_2645 abamectin 100 µM -0.148726872002829 0.446683661813088 no 1871 0.440884578132135 2715 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1026 k007-1105 30.6 µM -0.148858518116137 0.446628358911175 no 1872 0.440832637093875 2660 7066794 SGTC_1635 st007035 42.4 µM -0.148878485937713 0.446619970767243 no 1873 0.440824758869007 2648 3716403 SGTC_1686 st019653 115.5 µM -0.149083395144146 0.446533893258048 no 1874 0.440743914107568 2663 97252 SGTC_1475 4092-1048 11.7 µM -0.149858552721237 0.446208290724996 no 1875 0.440438106249397 2720 2881759 SGTC_1445 4239-0156 97.7 µM -0.150222088222698 0.446055601246141 no 1876 0.440294699876242 2854 4008346 SGTC_851 0394-0702 453 µM -0.150870970967385 0.445783082235443 no 1877 0.440038750071379 2674 762646 SGTC_724 3910-0327 137 µM -0.15105630342003 0.445705250655854 no 1878 0.439965650850444 2713 2885483 SGTC_2341 7987486 176.74 µM -0.151340115553874 0.445586065944395 no 1879 0.43985371303107 2768 1258686 SGTC_147 4466-0538 29.23 µM -0.151788826418619 0.445397643322848 no 1880 0.439676747620904 2864 6742687 YHR072W ERG7 SGTC_1657 st012939 43.4 µM -0.152408763663362 0.445137339636734 no 1881 0.439432272711363 2809 24207257 SGTC_766 1391-0721 126 µM -0.152694055261449 0.4450175572996 no 1882 0.439319774501903 2861 1020919 YIL115C NUP159 SGTC_2651 TUB2.036 5 µM -0.153284298011414 0.444769754327364 no 1883 0.43908704135582 2757 15992207 YFL037W TUB2 SGTC_1187 1391-0724 117 µM -0.153468999904149 0.444692214935822 no 1884 0.439014217586617 2709 6997986 SGTC_3086 9117350 49.47 µM -0.155408945246427 0.44387793814866 no 1885 0.438249466278779 2676 2679265 SGTC_2425 5628681 7.85 µM -0.156229457483814 0.443533605677307 no 1886 0.437926079051051 2776 5714958 SGTC_634 1611-4317 11.2 µM -0.156459824883878 0.443436938384819 no 1887 0.437835292145133 2672 2843522 SGTC_687 k029-0044 34.9 µM -0.157887690067158 0.442837849656357 no 1888 0.437272649148561 2795 5829338 SGTC_1479 0549-0158 134 µM -0.159002008281063 0.442370406390801 no 1889 0.436833645791213 2729 5440202 SGTC_1411 3909-8223 150 µM -0.159294696633655 0.442247640377315 no 1890 0.436718349441909 2730 X1411 SGTC_2075 5212009 200 µM -0.160443158460884 0.441765980053291 no 1891 0.436265997205357 2798 780898 SGTC_515 4092-1064 102 µM -0.160905516155181 0.441572093342336 no 1892 0.436083908828128 2873 717353 SGTC_73 0327-0325 16.231 µM -0.16142066908607 0.441356083780984 no 1893 0.435881044282262 2874 53298 SGTC_3115 9123671 49.47 µM -0.162068731219144 0.441084368640546 no 1894 0.43562586474838 2665 3286988 SGTC_121 0557-0495 61.343 µM -0.162694570400617 0.440821997308792 no 1895 0.435379461111864 2689 3104427 SGTC_1736 st036774 51 µM -0.164393754477456 0.440109777595958 no 1896 0.434710589946798 2979 1272247 SGTC_1433 4060-0023 7.6 µM -0.164956841902334 0.439873799906986 no 1897 0.43448897589199 2820 3840627 SGTC_1797 st048695 56.8 µM -0.166598703875329 0.439185853509875 no 1898 0.433842906801845 2829 592262 YIL048W NEO1 SGTC_910 3454-3003 490 µM -0.166660151317169 0.439160110350755 no 1899 0.433818730787745 2727 820824 SGTC_1176 0848-0131 83.3 µM -0.167082309369553 0.438983255891488 no 1900 0.433652642710834 2803 6769040 SGTC_2934 9036370 36.88 µM -0.167270469562932 0.438904433959085 no 1901 0.433578619316328 2808 6462800 SGTC_273 hydroxyurea 18.1 mM -0.167510441548385 0.438803911134591 no 1902 0.433484216220122 2707 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1895 st058434 18.3 µM -0.167569386319367 0.438779220127386 no 1903 0.433461028390037 2865 5393175 SGTC_1970 st070122 35.8 µM -0.169103962742012 0.438136495104857 no 1904 0.432857434002075 2862 102928 SGTC_1899 st063254 59.6 µM -0.169518133584468 0.437963056256267 no 1905 0.432694555115744 2681 3093813 SGTC_798 1287-0182 476 µM -0.169762057544291 0.437860915839898 no 1906 0.432598633714409 2786 1649755 SGTC_82 0054-0107 293.755 µM -0.169848511992454 0.437824715004881 no 1907 0.432564637056822 2785 3104697 SGTC_2958 9077254 16.72 µM -0.170128078258242 0.437707656549341 no 1908 0.432454706066876 2888 16457351 SGTC_1144 3486-0183 12.5 µM -0.17039725999443 0.437594951398529 no 1909 0.432348863420154 2729 6744069 SGTC_1630 st005209 31.3 µM -0.17165685432779 0.437067632486154 no 1910 0.431853653741591 2692 3367314 SGTC_763 3453-1109 128 µM -0.172449017064859 0.436736057203366 no 1911 0.431542269646722 2702 1560353 SGTC_3316 9136639 10.545 µM -0.174745432434742 0.435775099384444 no 1912 0.430639833526512 2809 4903665 SGTC_2323 6148992 148.28 µM -0.176801102429982 0.434915205212603 no 1913 0.429832311541353 2771 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1862 st057513 3.81 µM -0.176914800019147 0.434867654045145 no 1914 0.429787656630094 2745 5393163 SGTC_3322 9139058 2.11 µM -0.177612401460946 0.434575920370928 no 1915 0.429513692223646 2891 4908926 YPR165W RHO1 SGTC_627 1391-0720 175 µM -0.17774990533457 0.434518421088865 no 1916 0.429459695236122 2810 997839 SGTC_848 0368-0089 85.6 µM -0.179291443969008 0.433873898953291 no 1917 0.428854432362695 2829 762535 SGTC_832 4083-0019 164 µM -0.179312740489302 0.43386499603841 no 1918 0.428846071759813 2844 1990758 SGTC_2516 gossypol 71.55 µM -0.179880375119603 0.433627711303512 no 1919 0.428623241136256 2867 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1943 st076331 65.2 µM -0.181306180362767 0.43303179658815 no 1920 0.428063627598191 2788 24208415 SGTC_2307 7538926 6.34 µM -0.182052531749687 0.432719919953272 no 1921 0.427770750146623 2792 96582 SGTC_880 0833-0487 87.2 µM -0.182580252702489 0.432499427340493 no 1922 0.427563689968278 2737 76075 SGTC_3253 9135987 49.47 µM -0.182851676533712 0.432386029090727 no 1923 0.427457200035369 2858 4182430 SGTC_456 gingerol 170 µM -0.183082955217312 0.432289407489368 no 1924 0.427366464746744 2899 442793 A herb. SGTC_1215 3852-0577 11.2 µM -0.183300429683532 0.432198556588063 no 1925 0.427281148635529 2896 2884876 SGTC_2048 5246248 200 µM -0.184839567221883 0.431555677952277 no 1926 0.426677436197997 2778 677046 SGTC_1459 k035-0031 35.7 µM -0.186157537392442 0.431005322162472 no 1927 0.426160611044501 2723 3877128 YMR208W ERG12 SGTC_114 0364-0001 490.298 µM -0.186581738170857 0.430828213550435 no 1928 0.425994293061583 2790 4003655 SGTC_1320 1313-0481 95.3 µM -0.187556061817406 0.430421475157475 no 1929 0.425612336237451 2854 6813365 YLR208W SEC13 SGTC_3017 9080681 49.47 µM -0.18767157704262 0.430373257384146 no 1930 0.425567056287212 2816 16451914 SGTC_285 1486-1325 46 µM -0.187990841912461 0.430239996880272 no 1931 0.425441915143208 2841 22310230 SGTC_1663 st014140 55.4 µM -0.188386591106589 0.430074823005697 no 1932 0.42528680513021 2744 4207120 SGTC_199 4063-0024 41.6 µM -0.188652392493721 0.429963892325615 no 1933 0.425182633374979 2862 306215 SGTC_1613 st002381 52.1 µM -0.189576911216109 0.429578092865248 no 1934 0.42482034063512 2743 551167 SGTC_444 curcumin 90.4 µM -0.189606354456867 0.429565807373958 no 1935 0.424808803703429 2867 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3033 9090887 49.47 µM -0.19007936701331 0.429368447438361 no 1936 0.424623469029969 2753 19325384 SGTC_673 1082-0474 110 µM -0.191361111904405 0.428833740589324 no 1937 0.42412134260993 2758 3098046 SGTC_1448 4255-0083 152 µM -0.192210350362354 0.428479534761595 no 1938 0.42378871932584 2911 5399660 SGTC_2999 9069765 71.4286 µM -0.19238842829963 0.428405268168984 no 1939 0.423718977986747 2830 2097066 SGTC_399 oxolinic acid 75 µM -0.194973366310921 0.427327518370695 no 1940 0.422706899037057 2739 4628 A DNA gyrase inhibitor. SGTC_1378 2093-0007 380 nM -0.195575093601784 0.427076715007163 no 1941 0.422471378108691 2856 3618014 SGTC_3313 9133968 57.047 µM -0.196344716406802 0.426755974807321 no 1942 0.422170181923014 2726 1494643 SGTC_1339 1486-1321 22.7 µM -0.196439609997535 0.42671643126541 no 1943 0.42213304793416 2770 3469382 SGTC_1436 4092-1007 8.32 µM -0.199714002719214 0.425352397964824 no 1944 0.420852130905094 2764 2881121 SGTC_764 1951-2361 146 µM -0.20029790731522 0.425109250699565 no 1945 0.420623799553908 2774 5438930 SGTC_166 k072-0058 166.424 µM -0.200310648789849 0.425103945261837 no 1946 0.420618817396776 2779 5846229 SGTC_2469 5655019 90.81 µM -0.201108571723949 0.424771724246547 no 1947 0.420306839829182 2905 2788239 SGTC_2741 miltefosine 3.04 µM -0.201488839728296 0.424613415681897 no 1948 0.420158177549318 2791 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1982 st072467 71.9 µM -0.202159413920804 0.424334280007102 no 1949 0.41989605049959 2713 3163533 SGTC_631 k072-0230 41.5 µM -0.202911481725135 0.424021266654497 no 1950 0.419602109923255 2873 5773147 SGTC_3041 9091929 49.47 µM -0.202922641494675 0.424016622278237 no 1951 0.419597748540703 2912 25236887 SGTC_2179 6298986 200 µM -0.203841056573208 0.423634440472421 no 1952 0.419238853927613 2897 738374 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.204089623169963 0.423531016319204 no 1953 0.419141731595569 2963 688798 SGTC_1732 st034308 51.822 µM -0.204154509363423 0.423504019191495 no 1954 0.419116379448507 2705 830119 SGTC_846 0335-0850 148 µM -0.204555988462518 0.423336984210548 no 1955 0.418959522160016 2772 6819598 SGTC_856 0433-0016 11.3 µM -0.206132587035619 0.42268117549631 no 1956 0.418343672279782 2851 3911780 SGTC_1820 st053765 18.6 µM -0.20663439262759 0.422472487147177 no 1957 0.418147699227385 2828 3690829 SGTC_1558 st069300 45.6 µM -0.206940547218078 0.422345175822276 no 1958 0.418028144874209 2835 24208000 SGTC_2134 5324836 1.464 µM -0.207310476654761 0.422191355190008 no 1959 0.417883696344507 2814 699272 SGTC_1202 1988-0068 29.6 µM -0.207409714849099 0.422150092900971 no 1960 0.41784494810489 2781 2850480 SGTC_1529 apigenin 74 µM -0.207904518194697 0.421944371177546 no 1961 0.417651760624184 3016 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2294 7971431 200 µM -0.208785084954799 0.421578315386205 no 1962 0.417308007614821 2912 5741572 SGTC_500 h-89 112 µM -0.211007894950313 0.420654584789336 no 1963 0.416440555388349 2962 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1871 st057448 67.3 µM -0.21157556027228 0.42041875057059 no 1964 0.416219088878704 2956 691747 SGTC_168 3970-0862 530.542 µM -0.213285951853227 0.419708348459919 no 1965 0.415551965132447 2862 3135186 SGTC_1932 st074806 40.9 µM -0.213379916827023 0.419669328163355 no 1966 0.415515321924481 3018 17251235 SGTC_76 0433-0009 400.328 µM -0.213674070843347 0.419547181617492 no 1967 0.415400616413485 2915 2841569 SGTC_887 0885-0007 9.62 µM -0.213905049670884 0.419451273805974 no 1968 0.415310551152711 2915 5719458 SGTC_1391 3442-0225 151 µM -0.214624680033302 0.419152497150721 no 1969 0.415029975211154 2786 5227075 SGTC_868 0527-0199 213 µM -0.215895970811855 0.418624795740877 no 1970 0.414534418934357 2824 2849450 SGTC_2840 9008771 71.43 µM -0.216107837251071 0.418536866087632 no 1971 0.414451845407903 2943 2992978 SGTC_237 nikkomycin 200 µM -0.217156941902561 0.418101522559048 no 1972 0.414043019671248 2938 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1990 st072050 59.8 µM -0.217607691941806 0.417914507069087 no 1973 0.413867395403263 2750 17233948 SGTC_411 enrofloxacin 100 µM -0.218940516136696 0.417361629119979 no 1974 0.413348192359006 2948 71188 A bacterial gyrase inhibitor. SGTC_326 k292-0812 17.5 µM -0.21955625700359 0.417106264522027 no 1975 0.413108380971579 2855 3579357 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.219814665316919 0.416999105928702 no 1976 0.413007748844943 2994 94937 An inhibitor of serotonin biosynthesis. SGTC_2759 disulfiram 3.38 µM -0.219984074482059 0.416928857479502 no 1977 0.412941778819197 2778 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_461 N-acetylfarnesylcysteine 136 µM -0.220280455301388 0.416805964411527 no 1978 0.412826370373751 2800 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3163 9099914 49.47 µM -0.22060304952575 0.416672211304963 no 1979 0.412700763190775 2890 16268368 SGTC_3003 9075612 71.4286 µM -0.220869343400608 0.416561808557561 no 1980 0.412597084176891 2867 6501993 SGTC_3190 9110366 49.47 µM -0.221231555108679 0.416411649812503 no 1981 0.412456070246747 2886 17123768 SGTC_1700 st030840 7.9285 µM -0.221876165588916 0.416144449814048 no 1982 0.412205142604022 2907 5499307 SGTC_2296 7971656 126.45 µM -0.222388673661148 0.415932035746413 no 1983 0.412005664093858 2870 666570 SGTC_669 0108-0021 26.2 µM -0.224928460898303 0.414879759213251 no 1984 0.411017463975963 2800 17201 SGTC_2786 7743617 45.45 µM -0.22767368499312 0.413743053385928 no 1985 0.409949965765068 2842 583674 SGTC_2058 5236698 133 µM -0.228282605366077 0.413491017304175 no 1986 0.409713273238286 2834 766665 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.228631000704797 0.41334683024197 no 1987 0.409577863798968 2990 551469 SGTC_919 tnp00227 403.569 nM -0.228780485834011 0.413284967836102 no 1988 0.409519767310351 2834 1269246 A methoxyflavone. YNL221C POP1 SGTC_1768 st044301 37.178 µM -0.228972486422384 0.413205514138994 no 1989 0.409445150361421 2856 3931349 SGTC_900 1112-0045 141 µM -0.229066714760337 0.413166521861631 no 1990 0.409408531719912 2832 56211 YIL048W NEO1 SGTC_984 1492-0255 2.91 µM -0.229074967487008 0.413163106872351 no 1991 0.409405324615772 2929 1585198 SGTC_1229 0139-0193 12.2 µM -0.229498143692305 0.412988004807354 no 1992 0.409240881624794 2930 3090752 SGTC_2319 6033012 152.6 µM -0.229852920933899 0.412841218237781 no 1993 0.409103030245827 2828 847246 SGTC_3102 9121669 49.47 µM -0.230098543515621 0.412739600772853 no 1994 0.409007598319224 2837 41905072 SGTC_3198 9112019 49.47 µM -0.231095108427719 0.412327368124137 no 1995 0.408620457594326 2799 45595555 SGTC_3095 9117207 49.47 µM -0.231402136096565 0.412200384493027 no 1996 0.408501202914778 2946 17015229 SGTC_575 k072-0246 11.9 µM -0.231477188783396 0.412169344835747 no 1997 0.408472052484722 2789 6796779 SGTC_556 4058-0063 51.5 µM -0.231897343673037 0.411995590872131 no 1998 0.408308873870552 2849 6615692 SGTC_3076 9116187 49.47 µM -0.232092770110906 0.411914778652362 no 1999 0.408232980097177 2925 27241210 SGTC_2244 6635614 200 µM -0.232188112020015 0.411875354475771 no 2000 0.4081959553568 2767 836499 SGTC_1274 0865-0114 173 µM -0.233231531049997 0.411443955672767 no 2001 0.407790811331374 2865 870624 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.233299956920145 0.411415668914452 no 2002 0.407764246027875 3170 5282309 SGTC_1027 k015-0025 8.67 µM -0.233819743170988 0.411200808093841 no 2003 0.407562460775394 2800 3598955 SGTC_2688 kanamycin b 96.69 µM -0.234944566512945 0.410735938102182 no 2004 0.407125879221991 2947 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_37 0566-0070 1.56 µM -0.235017888278111 0.410705639832517 no 2005 0.407097424592376 2921 1626686 SGTC_2993 9054257 71.4286 µM -0.235106723164171 0.410668931892017 no 2006 0.407062950304866 2798 6470217 YGL055W OLE1 SGTC_1252 0493-0875 34.8 µM -0.235536836559869 0.410491213495893 no 2007 0.406896045741148 2798 3960963 SGTC_1756 st041558 35.5 µM -0.236564499578046 0.410066668265206 no 2008 0.406497331865806 3009 3955792 SGTC_1502 4534-4282 27.7 µM -0.2371221319477 0.40983634484054 no 2009 0.406281021558216 2852 3278949 SGTC_1357 1503-1303 39.5 µM -0.23719160599902 0.409807651586761 no 2010 0.406254073989008 2837 292895 SGTC_1164 k060-0068 93.7 µM -0.238818258957039 0.409135971259085 no 2011 0.40562325562208 2823 5963676 SGTC_539 4859-0462 2.54 µM -0.239516201501133 0.408847857277139 no 2012 0.405352667518954 3008 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_179 1273-0063 6.77 µM -0.239818500101884 0.408723082260956 no 2013 0.405235482210267 2833 3108139 SGTC_2400 5203494 178.7 µM -0.239883370305042 0.408696308017484 no 2014 0.405210336542396 2782 6777674 SGTC_1651 st011928 86.1 µM -0.240916258827883 0.408270055620159 no 2015 0.40481001025349 2948 720198 SGTC_2171 5739187 198.077 µM -0.241217603381222 0.408145717187016 no 2016 0.40469323407058 2775 2262761 SGTC_32 0928-0142 34.1 µM -0.242065251346867 0.40779601694688 no 2017 0.404364801496261 2866 2244242 SGTC_2972 9093619 59.92 µM -0.242141354854087 0.407764623758236 no 2018 0.404335317464732 2829 25236256 SGTC_1999 st074831 12.5 µM -0.246303671976866 0.406048548280986 no 2019 0.402723583832587 2864 17112523 SGTC_2780 5215298 71.43 µM -0.246481759110135 0.405975165005113 no 2020 0.402654661536684 2982 2834131 SGTC_1938 st074717 56.4 µM -0.247777001204045 0.405441542058706 no 2021 0.40215347526204 2798 17250979 SGTC_3239 9133757 49.47 µM -0.248569007568084 0.405115332210843 no 2022 0.401847092263234 2825 17036923 SGTC_2807 7945238 51.95 µM -0.24878575908757 0.405026068547616 no 2023 0.401763253717859 2947 17148797 SGTC_2449 5812982 45.77 µM -0.248848087543057 0.405000401054941 no 2024 0.40173914617901 2890 776185 SGTC_2203 7227154 166.4 µM -0.249114065228193 0.404890873330053 no 2025 0.401636274940912 2838 896304 SGTC_3329 9141233 27.5565 µM -0.249281657436561 0.40482186387264 no 2026 0.401571459401771 3011 4909101 YNL103W MET4 SGTC_3171 9103192 49.47 µM -0.249781107991465 0.404616222639966 no 2027 0.401378315193004 2907 13018434 SGTC_29 0299-0004 12.984 µM -0.253334617347539 0.403153882454507 no 2028 0.400004823798699 2862 16871 A napthoquinone isolated from Swertia calycina. SGTC_2790 5423970 71.43 µM -0.254409091642527 0.40271198032521 no 2029 0.399589763936716 3036 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2769 toremifene 3.73 µM -0.255345028597037 0.402327156084985 no 2030 0.399228312247566 3050 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2154 5570129 200 µM -0.255547919945778 0.402243746792871 no 2031 0.399149968542449 2849 673366 SGTC_2079 5212404 121 µM -0.256196477595467 0.401977152509637 no 2032 0.398899564181214 2974 758462 SGTC_543 3844-1095 191 µM -0.256303827121111 0.401933030110826 no 2033 0.398858121159977 2949 4230703 SGTC_311 1315-0136 58 µM -0.256318845349106 0.401926857474809 no 2034 0.398852323360881 3035 6759207 SGTC_1369 1866-0067 208 µM -0.257081905989065 0.401613264449518 no 2035 0.398557772583693 2989 3531355 SGTC_2246 7293507 91.5585 µM -0.257432478888136 0.40146921165201 no 2036 0.398422466499644 3029 887656 SGTC_3314 9135860 59.4275 µM -0.257924698992703 0.401266977652496 no 2037 0.398232511288561 3008 25252478 SGTC_2863 9028737 58.44 µM -0.258439666533408 0.401055425930399 no 2038 0.398033803308987 2964 6460917 SGTC_224 benfluorex 43.875 µM -0.260377806557414 0.400259487025409 no 2039 0.397286180252213 2963 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1526 st051518 75 µM -0.260551710773022 0.400188089712867 no 2040 0.397219116400044 2922 673993 SGTC_2013 4024628 200 µM -0.261168168431771 0.399935026586375 no 2041 0.396981412177546 3019 5230760 SGTC_1664 st014217 9.02 µM -0.261238147753185 0.399906301904811 no 2042 0.3969544307783 2892 3982782 SGTC_408 cantharidin 100 µM -0.262690544830336 0.399310253375624 no 2043 0.396394552526451 2913 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2745 rifampicin 24.3 µM -0.262925733252411 0.399213756551906 no 2044 0.396303910824407 2930 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1062 mesoridazine 14.2 µM -0.263221206601508 0.399092533804049 no 2045 0.396190043234452 2853 4078 A neuroleptic. SGTC_1840 st055363 71 µM -0.265864774137145 0.39800840152295 no 2046 0.395171677579385 2889 676033 SGTC_3339 9145883 14.936 µM -0.266103966293467 0.397910347047485 no 2047 0.395079570219475 3016 2030670 SGTC_1882 5615643 20 µM -0.267205164555796 0.397459004903224 no 2048 0.394655599969966 2875 2253075 SGTC_2813 7971799 71.43 µM -0.267316538647047 0.397413364242766 no 2049 0.394612726980507 2984 2234054 SGTC_1362 1611-0397 101 µM -0.269523521605804 0.396509241825405 no 2050 0.393763422032324 2896 27816 SGTC_1304 1165-0502 251 µM -0.269858520143822 0.396372053340364 no 2051 0.393634549859239 2900 767425 SGTC_42 0133-0086 60.653 µM -0.269998797689386 0.396314610738617 no 2052 0.393580589286036 2831 162923 Model of phenazepam hydroxylation. SGTC_94 0334-0113 514.748 µM -0.270980931274513 0.395912497520926 no 2053 0.393202849191329 2904 6795178 SGTC_680 0417-1641 114 µM -0.272107710545213 0.395451298704994 no 2054 0.392769600504372 2870 2835990 SGTC_2761 levamisole 97.89 µM -0.272994508769682 0.395088428749761 no 2055 0.392428718340069 3040 26879 An alkaline phosphatase inhibitor. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.273069070119335 0.395057923049345 no 2056 0.392400060972743 2824 4000243 SGTC_2566 crystal violet carbinol 226 nM -0.273235538582716 0.394989817200884 no 2057 0.39233608156629 3047 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_248 streptozotocin 5.23457 mM -0.27328419861508 0.394969909935189 no 2058 0.392317380435516 2982 5300 DNA alkylating agent. SGTC_622 1348-1566 26.3 µM -0.274973178399544 0.394279103072129 no 2059 0.391668422412108 2981 7340407 SGTC_735 3076-0345 636 µM -0.275445816964564 0.394085849377273 no 2060 0.391486874011598 3053 2888990 SGTC_1437 4092-1038 11.6 µM -0.277077421284432 0.393418915380503 no 2061 0.390860329275415 2908 3977136 SGTC_1491 4138-0063 26.5 µM -0.278486125437397 0.392843345355059 no 2062 0.390319607129164 2971 23883227 SGTC_3176 9106582 49.47 µM -0.279834432891645 0.392292671629034 no 2063 0.389802266500657 2972 17018027 SGTC_1338 1486-1223 76 µM -0.280501772506919 0.392020197473804 no 2064 0.389546282882343 2969 3444526 SGTC_2646 retinol 96.75 µM -0.280684933664128 0.391945422194882 no 2065 0.389476032794658 2971 445354 A vitamin A analog and teratogen. SGTC_2722 naftopidil 47.16 µM -0.281246359858227 0.391716245634424 no 2066 0.389260724500202 2987 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1149 3909-7961 23.3 µM -0.281395636900748 0.391655316430603 no 2067 0.389203482114133 2922 735261 SGTC_702 1488-0190 94 µM -0.286009688136897 0.389773353978618 no 2068 0.387435350657133 2998 949357 SGTC_890 0929-0006 47.2 µM -0.286738302215171 0.389476404391057 no 2069 0.387156353771073 2912 1378169 SGTC_398 bronopol 33.3 µM -0.288899121770523 0.388596133748637 no 2070 0.386329287905886 2887 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1489 4065-0444 182 µM -0.289236562939335 0.388458719098299 no 2071 0.386200176901406 3044 2877968 SGTC_2739 tacrine 100.86 µM -0.289305127765564 0.388430799458102 no 2072 0.386173944316895 3014 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2441 5730946 39.09 µM -0.290029139154486 0.38813601677483 no 2073 0.385896972697051 3041 1774275 SGTC_1299 1079-1439 3.74 µM -0.290674827330467 0.387873177896493 no 2074 0.385650012790616 2947 323161 SGTC_1766 st045414 44.774 µM -0.292547719575715 0.387111074702702 no 2075 0.384933939920356 2919 253960 SGTC_1931 st074438 57.1 µM -0.292798814573411 0.387008934020963 no 2076 0.384837967199996 2857 2787313 SGTC_1653 st012112 65 µM -0.294919930453921 0.386146417181352 no 2077 0.384027523222368 3096 720429 SGTC_188 3229-0966 278.469 µM -0.295234063978277 0.386018727667058 no 2078 0.383907540904812 3035 5722370 SGTC_1476 4112-3294 3.34 µM -0.295347302739021 0.38597270121526 no 2079 0.383864292442078 3057 704369 SGTC_3015 9080845 49.47 µM -0.295955068229444 0.385725699378633 no 2080 0.383632197680805 3060 5296973 SGTC_1633 st005664 67.9 µM -0.296113616627545 0.385661271375103 no 2081 0.383571657747775 2891 2063822 SGTC_2149 5554786 194.827 µM -0.296895006042679 0.385343790724482 no 2082 0.383273334483867 2938 745063 YPR165W RHO1 SGTC_2353 9059630 146.67 µM -0.297550535271935 0.385077506657956 no 2083 0.383023116204155 3043 4779114 SGTC_249 wiskostatin 11.211 µM -0.298158120831603 0.384830746283589 no 2084 0.382791241801626 2961 2775510 A n-wasp and actin depolymerizer. SGTC_3309 9129340 25.759 µM -0.298195129034171 0.384815717547767 no 2085 0.382777119624663 2974 17158987 SGTC_1194 1488-0194 225 µM -0.298317817370096 0.384765896031329 no 2086 0.382730303378179 2899 1391452 SGTC_31 0508-1974 57.237 µM -0.298575116216119 0.384661417799545 no 2087 0.382632127106669 3043 6810525 SGTC_406 estrone 100 µM -0.29929334997969 0.384369817644699 no 2088 0.382358114065318 3104 5870 A steroid. SGTC_3306 9127676 59.7925 µM -0.299334149509792 0.384353255154118 no 2089 0.382342550421489 3012 41905287 SGTC_2478 5763493 32.33 µM -0.300193058748999 0.384004631656852 no 2090 0.382014949689172 2928 1365576 YLR208W SEC13 SGTC_921 1561-0023 372 µM -0.300959090617349 0.383693785401937 no 2091 0.3817228450099 2898 24050882 SGTC_647 0140-0236 81 µM -0.301781595789836 0.383360106290183 no 2092 0.38140928079521 2984 990837 SGTC_952 1185-0122 232 µM -0.3034005754408 0.382703561282714 no 2093 0.380792303595508 2899 678600 SGTC_2480 5767542 37.17 µM -0.304046952234197 0.382441530033755 no 2094 0.380546060314633 2977 2867358 SGTC_151 3013-0144 2.285 µM -0.304590874179369 0.382221074102545 no 2095 0.380338885654021 3131 906558 YHR107C CDC12 SGTC_1201 1889-3372 45.9 µM -0.305234475350618 0.381960266695474 no 2096 0.380093788466295 2968 5392199 SGTC_2717 st081029 62.2815 µM -0.305559753516084 0.381828474135372 no 2097 0.37996993384436 3055 5292846 SGTC_2695 st077686 51.995 µM -0.306698704623828 0.381367114719016 no 2098 0.379536357929232 2996 2876092 SGTC_3216 9129716 49.47 µM -0.307023637610926 0.381235523702592 no 2099 0.379412690178347 2960 8056934 SGTC_2975 9084847 53.72 µM -0.307607128079596 0.380999256826641 no 2100 0.379190647813009 3027 27211724 SGTC_401 neomycin 50 µM -0.309623294006679 0.380183213171103 no 2101 0.378423720084897 3000 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1778 st046819 58.9 µM -0.309677010919317 0.380161478512069 no 2102 0.378403293285046 2963 671715 SGTC_1402 3909-7673 35.9 µM -0.312290955339786 0.379104296335402 no 2103 0.377409706587993 2891 5328014 SGTC_1290 0986-0249 10.2 µM -0.312623356656741 0.378969924733755 no 2104 0.377283415463912 3016 53329 SGTC_1033 k072-0102 21.3 µM -0.313760401460828 0.378510390621452 no 2105 0.376851510859751 3134 5965931 SGTC_3034 9090421 49.47 µM -0.314551036564288 0.378190958403304 no 2106 0.376551280187608 2960 17173761 SGTC_1720 st037298 9.481 µM -0.315790705189797 0.3776902754145 no 2107 0.376080686785704 3043 597396 SGTC_1642 st009582 77.7 µM -0.316515793261278 0.377397518719034 no 2108 0.375805519800045 3113 6739311 SGTC_834 0312-0008 75.7 µM -0.317051167459353 0.377181404817934 no 2109 0.375602388715485 2960 6385573 YIL048W NEO1 SGTC_2435 5706476 10.6 µM -0.318227585058047 0.376706656849424 no 2110 0.375156154841983 3109 5725375 SGTC_3067 9117431 49.47 µM -0.319568644177673 0.376165694515109 no 2111 0.374647673580487 2997 17150885 SGTC_3243 9134147 49.47 µM -0.32045741961204 0.375807310297826 no 2112 0.374310801974775 3035 24282180 SGTC_1654 st012436 41.8 µM -0.321097047368245 0.375549457082239 no 2113 0.374068423897226 3042 4323132 SGTC_1941 st076221 61.8 µM -0.322265663931162 0.375078496154134 no 2114 0.37362572144817 3096 2828568 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.322959595271282 0.374798924862233 no 2115 0.373362920993555 2953 803109 SGTC_1316 1272-0050 65.9 µM -0.323303583920112 0.374660362978193 no 2116 0.373232670025938 2977 7340392 SGTC_3088 9117578 49.47 µM -0.323477283052237 0.374590401470875 no 2117 0.373166904521233 3036 678341 SGTC_2822 7994718 71.43 µM -0.32397414191228 0.374390302402863 no 2118 0.372978805545478 2944 1018011 SGTC_3089 9117425 49.47 µM -0.324702990796669 0.374096835632595 no 2119 0.372702935442637 3030 9401657 SGTC_825 1988-2224 89.6 µM -0.324955849787821 0.373995040464226 no 2120 0.372607243282449 2973 1180859 SGTC_1973 st070275 50.2 µM -0.327529146338545 0.372959591781293 no 2121 0.371633850972698 3018 17118334 SGTC_1815 st051655 58.2 µM -0.33020258738444 0.371884817991178 no 2122 0.370623445967333 3081 5984156 SGTC_1222 0366-0074 1.18 µM -0.330534809166102 0.371751328079567 no 2123 0.370497947632873 3100 286520 SGTC_1183 1254-0324 198 µM -0.331231098334977 0.371471602422167 no 2124 0.370234965858495 3121 5799357 SGTC_549 1661-1316 519 µM -0.331296507334206 0.371445328641474 no 2125 0.370210264617996 3132 2857282 SGTC_2138 5575593 77.673 µM -0.333341364940823 0.370624243688697 no 2126 0.369438309191863 3003 762213 SGTC_201 4262-0159 12.803 µM -0.333363427067576 0.370615388144352 no 2127 0.369429983368165 3045 1341029 SGTC_2948 9070189 9.45 µM -0.333500977463991 0.370560178166776 no 2128 0.369378075866594 3132 6473636 YDL196W YDL196W SGTC_3127 9126946 49.47 µM -0.333967004480355 0.370373144066053 no 2129 0.369202228588916 3068 27243249 SGTC_946 3434-1334 87.4 µM -0.334895271441848 0.370000687095717 no 2130 0.368852044597077 3130 4047976 SGTC_1627 st003713 25.6 µM -0.336653677259277 0.369295480377886 no 2131 0.368188993540465 3082 16195070 YER133W GLC7 SGTC_508 roscovitine 141 µM -0.337306833039431 0.369033644814857 no 2132 0.367942804606252 2983 160355 A CDKinase inhibitor. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.337663728912838 0.368890598894493 no 2133 0.367808305524384 3402 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2733 amorolfine 100 µM -0.337926071226644 0.368785462164199 no 2134 0.367709450046993 3050 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2657 nystatin 74.44 µM -0.338146199205764 0.368697250894964 no 2135 0.367626508479717 3057 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1263 0774-1208 64.8 µM -0.338716953062948 0.368468566530107 no 2136 0.367411484074914 3185 906585 SGTC_1798 st045719 60.953 µM -0.338780121084591 0.368443259814285 no 2137 0.367387688863308 3076 3980186 SGTC_387 norethindrone acetate 66.7 µM -0.339946245814292 0.367976183205553 no 2138 0.366948504597448 3032 541197 SGTC_2768 sulfasalazine 50.2 µM -0.34156188207401 0.367329382963948 no 2139 0.366340313686133 3148 5384001 An antioxidant and salicylic acid derivative. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.341647596882856 0.367295078581613 no 2140 0.366308056521528 3080 279621 SGTC_2563 tomatine 8.54 µM -0.34192048036042 0.367185873479598 no 2141 0.366205368222032 3209 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_69 0096-0274 206.684 µM -0.343563180769138 0.366528709307651 no 2142 0.365587409202567 3287 6741392 SGTC_2142 5622915 118.518 µM -0.343585219605482 0.36651989530072 no 2143 0.365579120892995 3044 5322196 SGTC_2570 licareol 100 µM -0.346071380538277 0.365526056175029 no 2144 0.364644535531559 3078 443158 SGTC_781 4335-2806 94.4 µM -0.346368039820945 0.36540752718459 no 2145 0.364533070413038 3150 845254 SGTC_1405 3909-7894 12 µM -0.346396636886268 0.365396102024368 no 2146 0.364522326114922 3093 7104060 SGTC_3208 9114115 49.47 µM -0.348242638184778 0.364658836801323 no 2147 0.363828984384522 3084 650895 SGTC_1698 5-fluorocytosine 1.055 µM -0.349018679651009 0.364349046684336 no 2148 0.363537642997396 3146 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2103 5378138 10 µM -0.353242695650386 0.362664408362693 no 2149 0.361953250947131 3061 244142 SGTC_2618 avocadyne 43.43 µM -0.353578133102189 0.362530741279507 no 2150 0.361827532167046 2966 3015189 SGTC_1836 st055642 81 µM -0.353605727459775 0.362519746063664 no 2151 0.361817190726711 3041 8571 SGTC_3077 9117319 49.47 µM -0.353614379999393 0.362516298406075 no 2152 0.361813948065653 3012 17154678 SGTC_630 4356-0227 183 µM -0.35446447099162 0.362177628820686 no 2153 0.361495412900841 3060 779312 SGTC_3182 9108849 49.47 µM -0.355002989538524 0.361963143042966 no 2154 0.361293675796857 3135 17133045 SGTC_730 1436-0052 41.2 µM -0.356741684107477 0.361270937082542 no 2155 0.360642598311903 3025 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_466 geldanamycin 89.2 µM -0.357563945447769 0.3609437378336 no 2156 0.360334832035389 3068 5288382 HSP90 inhibitor. SGTC_1540 guanosine 70.6 µM -0.357816067450641 0.360843432277043 no 2157 0.360240482768387 3042 6802 Guanosine is a purine nucleoside SGTC_236 1509-0011 5.31 µM -0.358688638216985 0.360496358010423 no 2158 0.359914014478285 3168 3107280 SGTC_929 2805-0021 398 µM -0.359915068611003 0.36000872662812 no 2159 0.359455324014537 3113 3098024 SGTC_2797 7859098 81.82 µM -0.362913868304983 0.358817357928984 no 2160 0.358334613313418 3038 972681 SGTC_2288 7946289 167.31 µM -0.366660948542668 0.35733064032163 no 2161 0.356935969634334 3239 1246052 SGTC_2391 6285546 200 µM -0.367828644434127 0.356867778169341 no 2162 0.35650050446699 3014 846083 SGTC_1088 bifonazole 369 nM -0.367880339898766 0.356847291504583 no 2163 0.356481230158245 3126 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2183 6420625 130.508 µM -0.367967995889099 0.356812554799489 no 2164 0.356448549045384 3101 2897619 SGTC_3085 9117376 49.47 µM -0.370979351869765 0.35561992405732 no 2165 0.355326455461272 3148 16480349 SGTC_192 3455-0609 60.9 µM -0.372626660909385 0.354968113212404 no 2166 0.354713163575533 3186 3769639 SGTC_1903 st060211 78.3 µM -0.373134687100116 0.354767181800561 no 2167 0.354524101677962 3220 688960 SGTC_824 1304-0008 100 µM -0.373267452108309 0.354714678052239 no 2168 0.354474699097604 3071 768245 SGTC_2275 7947463 200 µM -0.374853911398284 0.354087504678911 no 2169 0.353884558605831 3200 1225414 SGTC_2003 4023581 200 µM -0.376546915812415 0.353418647297806 no 2170 0.353255171842844 3194 16641307 SGTC_3057 9095946 49.47 µM -0.377083973421659 0.353206565696221 no 2171 0.3530556004791 3042 24540043 SGTC_1501 4491-0275 38.4 µM -0.377386095757956 0.353087278992251 no 2172 0.352943349151885 3176 5104718 SGTC_2228 7354201 200 µM -0.379000208181252 0.35245022519571 no 2173 0.352343854624886 3094 753451 SGTC_609 0986-0026 86.3 µM -0.379567334777645 0.352226491224643 no 2174 0.352133306148435 3081 2848610 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.38038144634138 0.351905409984739 no 2175 0.351831142550045 3317 6728940 SGTC_1268 0828-0275 2.46 µM -0.381002742292756 0.351660445206623 no 2176 0.351600606843765 3175 745337 SGTC_580 1123-0028 41 µM -0.382067527924599 0.351240764416941 no 2177 0.351205638479985 3072 1677248 YPR107C YTH1 SGTC_1964 st076914 61 µM -0.386531883703463 0.349483136487628 no 2178 0.34955139705788 3095 24208661 SGTC_2191 5911152 200 µM -0.38748422789156 0.349108611947029 no 2179 0.349198879535954 3136 2875902 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.387736046018416 0.349009604997863 no 2180 0.349105688851589 3106 688669 SGTC_3049 9092223 49.47 µM -0.388187729879249 0.348832042897326 no 2181 0.348938556377075 3169 8623917 SGTC_1942 st076330 65.2 µM -0.388235356254782 0.34881332235199 no 2182 0.348920935329346 3215 24208414 SGTC_1810 st050138 53 µM -0.389039629472334 0.348497241524169 no 2183 0.348623415484608 3221 3444541 SGTC_3248 9135562 49.47 µM -0.389660200968767 0.348253427666841 no 2184 0.3483939148954 3137 17650701 SGTC_2180 6301957 200 µM -0.389867161585675 0.348172129673143 no 2185 0.34831738877541 3214 845462 SGTC_2321 7390090 138.78 µM -0.391738959259157 0.347437169892247 no 2186 0.347625550378491 3127 649046 SGTC_1988 st071872 53.4 µM -0.391903523482835 0.347372581261571 no 2187 0.347564749731224 3221 16414116 SGTC_2458 5808907 16.39 µM -0.392325735027107 0.347206890758483 no 2188 0.34740877547063 3239 2731747 SGTC_2916 7875993 68.79 µM -0.392358988904827 0.347193842019714 no 2189 0.347396491851635 3243 1299250 SGTC_205 1486-1330 71.903 µM -0.393014270557404 0.346936748104366 no 2190 0.347154470681017 3113 4118834 SGTC_872 0588-0139 234 µM -0.393286464040913 0.346829976119882 no 2191 0.347053957285396 3096 2047100 SGTC_3108 9121785 49.47 µM -0.393791487237918 0.346631905404498 no 2192 0.346867494932413 3141 17140271 SGTC_2490 carminic acid 95.39 µM -0.394132182107872 0.346498308134114 no 2193 0.346741726073866 3168 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1107 amlodipine 47 µM -0.394527178394619 0.34634344145403 no 2194 0.346595932772117 3157 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1116 jasmonic acid  1.58368 µM -0.39509967131378 0.346119029048148 no 2195 0.346384665715973 3232 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_970 1315-0089 19.5 µM -0.395239751780358 0.346064126908432 no 2196 0.346332979096636 3175 6811083 YLR033W RSC58 SGTC_2650 prasterone 100 µM -0.395656403272842 0.345900846620177 no 2197 0.346179260752666 3161 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1098 clofazimine 15.1 µM -0.396379875782051 0.34561739525988 no 2198 0.345912404852384 3219 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_320 4092-0846 5.34 µM -0.397137202873841 0.34532077261475 no 2199 0.345633143517645 3187 1359356 SGTC_245 methotrexate 289.6 µM -0.39713885651487 0.34532012503628 no 2200 0.345632533835968 3174 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_563 tetrahydrosecaminediol 614 µM -0.39806168660065 0.344958808406616 no 2201 0.345292357684015 3240 334274 A psychoactive constituent of the cannabis plant. SGTC_2640 pentamidine 10.38 µM -0.398614090594995 0.344742592688407 no 2202 0.345088788773992 3214 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1611 st001856 99.4 µM -0.399097797580063 0.344553307207867 no 2203 0.344910572515685 3141 647478 SGTC_664 1222-0054 14.9 µM -0.399316109081753 0.344467889723849 no 2204 0.344830149426085 3118 6813991 SGTC_3005 9076496 71.4286 µM -0.39970196129636 0.344316938948555 no 2205 0.344688023685987 3218 21368410 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.399956727045501 0.344217284619116 no 2206 0.344594194664617 3057 688667 SGTC_1678 st019265 80.2 µM -0.400631535324075 0.343953378474621 no 2207 0.344345712176198 3309 5367020 SGTC_661 1304-0007 33.6 µM -0.400850501008102 0.343867761011633 no 2208 0.34426509757359 3140 3117130 SGTC_2050 5263056 171 µM -0.403024416617618 0.343018176260982 no 2209 0.343465131202894 3250 763468 YGL055W OLE1 SGTC_1413 3910-0535 34.4 µM -0.403774311088231 0.342725294848914 no 2210 0.343189344317087 3238 2876951 SGTC_686 1319-0111 510 µM -0.4048109726439 0.342320568335347 no 2211 0.342808231307029 3272 4562600 SGTC_1484 3473-2379 286 µM -0.40496817326841 0.342259210908118 no 2212 0.342750452818508 3227 671917 SGTC_2918 7977171 22.06 µM -0.405972439849455 0.341867331063169 no 2213 0.34238142533183 3137 2236483 SGTC_1367 1812-0510 76.9 µM -0.411077291762962 0.339877982391196 no 2214 0.340507930234731 3172 1142582 YDR527W RBA50 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.411548573088574 0.339694548771712 no 2215 0.340335166061348 3157 88881 An O-methylated flavonoid and antioxidant. SGTC_323 4013-0906 34.3 µM -0.414256379284784 0.338641344582044 no 2216 0.339343178021813 3222 2910086 SGTC_3356 9151811 4.48 µM -0.414341648385743 0.338608199502609 no 2217 0.33931195824459 3106 1859254 YPR165W RHO1 SGTC_873 0591-4978 488 µM -0.414368298863658 0.338597840411965 no 2218 0.339302200868431 3320 3305145 SGTC_336 4111-0029 111 µM -0.414673445064088 0.338479238218047 no 2219 0.339190487241507 3155 3131175 SGTC_1842 st055362 61.2 µM -0.417164472187508 0.337511642454039 no 2220 0.338279054897317 3126 676032 SGTC_858 0438-0351 2.77 µM -0.41719187643885 0.337501003711179 no 2221 0.338269033316875 3175 2799119 SGTC_1453 4237-0541 195 µM -0.417469294117453 0.33739331330655 no 2222 0.338167589685232 3263 739892 SGTC_328 k915-0120 63.5 µM -0.418435154164492 0.33701848131471 no 2223 0.337814494259323 3237 6624543 SGTC_3211 9128781 49.47 µM -0.419250248726944 0.33670228439637 no 2224 0.337516626098951 3192 17194361 SGTC_1773 st048542 73.5835 µM -0.419482270122035 0.336612298200665 no 2225 0.337431854800588 3135 3237138 SGTC_1658 st012944 20 µM -0.41962015318185 0.336558826649748 no 2226 0.337381481776783 3200 24207260 SGTC_302 1094-0063 18.9 µM -0.41972046340148 0.336519928059173 no 2227 0.337344837126021 3127 5440289 SGTC_878 0828-0289 13.7 µM -0.422867995406488 0.335300259422554 no 2228 0.336195787293023 3160 745350 YLR208W SEC13 SGTC_1672 st016598 6.51 µM -0.423740521336438 0.334962462054063 no 2229 0.335877529868636 3160 4665860 YNL267W PIK1 SGTC_593 1203-0218 61.7 µM -0.424164446507218 0.334798388090897 no 2230 0.335722943870768 3272 3666956 SGTC_1071 trifluoperazine 6.31 µM -0.424357466108384 0.334723693156229 no 2231 0.33565256771353 3279 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_637 1181-0519 7.26 µM -0.425655411817518 0.334221582682153 no 2232 0.335179478377132 3210 6252091 YGR060W ERG25 SGTC_3247 9135149 49.47 µM -0.426988846889953 0.333706051901977 no 2233 0.334693725612342 3173 8934436 YOR116C RPO31 SGTC_150 3970-0969 77.2 µM -0.42868357651926 0.33305129083877 no 2234 0.334076757122062 3265 6615640 SGTC_3009 9080819 71.4286 µM -0.429081502627815 0.33289762521272 no 2235 0.333931956514445 3215 17027216 SGTC_1761 st044296 37 µM -0.42924476793368 0.332834585781529 no 2236 0.333872553350589 3123 1826700 SGTC_1564 D-Arginine 115 µM -0.429884834789258 0.332587490984751 no 2237 0.333639708785967 3188 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2492 derrusnin 100 µM -0.43022380012612 0.332456664456998 no 2238 0.333516425363061 3116 1715307 Part of coumarin class of compounds. SGTC_3081 9117243 49.47 µM -0.430371131471687 0.332399807044639 no 2239 0.333462845805143 3309 45595589 SGTC_585 0kpi-0023 191 µM -0.431419121991838 0.331995482870679 no 2240 0.333081824251948 3253 64601 SGTC_354 2783-3500 4.88 µM -0.431678146511166 0.331895579000902 no 2241 0.332987676339796 3168 6740761 SGTC_1123 mangostin 811.285 nM -0.431690594785716 0.331890778093036 no 2242 0.332983152017524 3202 5281650 An antioxidant. SGTC_827 3253-0474 693 µM -0.431693708858873 0.331889577097305 no 2243 0.332982020212215 3272 5402065 SGTC_2627 acetyl isogambogic acid 100 µM -0.433972161719106 0.331011316365127 no 2244 0.332154328267577 3252 6857789 A caspase activator and apoptosis inducer. SGTC_3278 9139605 49.47 µM -0.436624257814125 0.32999019993202 no 2245 0.331191933671958 3327 7958859 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.436853416176036 0.329902028112619 no 2246 0.331108828714183 3236 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1550 gossypolone 36.6 µM -0.437413150470673 0.329686702411694 no 2247 0.330905874400125 3182 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2272 7805186 180 µM -0.437867244412287 0.329512057247377 no 2248 0.330741260771193 3291 2956062 YPR165W RHO1 SGTC_1343 1487-0095 224 µM -0.438633116885466 0.329217585871851 no 2249 0.33046369844457 3300 4560101 YGL055W OLE1 SGTC_2076 5212012 200 µM -0.438953417470569 0.329094464453972 no 2250 0.33034764491099 3199 604802 SGTC_1573 oleylamine 1.06 µM -0.439116724146114 0.329031697586343 no 2251 0.330288480780914 3189 5356789 An amine of the fatty acid oleic acid. SGTC_212 3807-4682 38.772 µM -0.440475165482177 0.328509768053857 no 2252 0.329796497657797 3255 3125501 YBL034C STU1 SGTC_2778 tioconazole 65.09 nM -0.440890784855857 0.328350148847393 no 2253 0.329646032643653 3220 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_341 1486-1430 230 µM -0.441198622863831 0.328231943419515 no 2254 0.329534605055682 3118 2054753 YPL210C SRP72 SGTC_1057 3448-5381 134 µM -0.441740423838447 0.328023941304391 no 2255 0.329338527060354 3269 5497911 SGTC_106 0092-0003 11.579 µM -0.442249598552113 0.327828513297273 no 2256 0.329154299290879 3220 1072148 SGTC_1180 1193-0155 285 µM -0.442445166501307 0.327753464252637 no 2257 0.329083550620201 3290 2921347 SGTC_1699 st031318 29.054 µM -0.442785599690464 0.327622839884528 no 2258 0.328960410097205 3274 5340658 SGTC_2298 7976326 193.81 µM -0.443377764465899 0.327395676259718 no 2259 0.328746258170802 3200 2235818 SGTC_564 3555-0129 330 µM -0.446324854711066 0.326266078299098 no 2260 0.327681302516959 3253 563260 SGTC_3268 9137683 49.47 µM -0.446545968344582 0.326181391145455 no 2261 0.327601457623175 3166 1953228 SGTC_3117 9124945 49.47 µM -0.447068009997242 0.325981483265834 no 2262 0.32741297786942 3141 17592065 SGTC_2583 asiatic acid 100 µM -0.447305423217134 0.325890586037754 no 2263 0.327327275913181 3358 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_144 4161-2749 112.381 µM -0.447553979742661 0.325795433514352 no 2264 0.327237561173061 3208 797501 YMR168C CEP3 SGTC_2438 5259590 200 µM -0.449105016757248 0.325201921338243 no 2265 0.326677950819085 3263 1201127 SGTC_2963 9082507 9 µM -0.44939888364825 0.325089521574305 no 2266 0.326571968241345 3312 16459611 SGTC_2820 7989630 71.43 µM -0.449450197401015 0.325069896450443 no 2267 0.326553463461675 3242 2984098 SGTC_3273 9137859 49.47 µM -0.449472967589246 0.325061188067926 no 2268 0.326545252206821 3283 2377234 SGTC_2278 7948257 134.34 µM -0.449662019524383 0.324988889477042 no 2269 0.326477080626554 3285 1247028 SGTC_2021 4019055 173 µM -0.451919720625137 0.324125993225141 no 2270 0.325663408529398 3346 44827708 YER133W GLC7 SGTC_91 0417-1751 58.384 µM -0.452273896782452 0.323990712184624 no 2271 0.325535839183095 3294 6795624 SGTC_1251 0490-5699 265 µM -0.45246547442202 0.323917546919919 no 2272 0.325466844085387 3370 3883818 SGTC_667 1498-1044 59 µM -0.453220545952881 0.323629244412304 no 2273 0.325194969591685 3226 6739982 SGTC_24 0417-1663 219 µM -0.45335782503264 0.323576839678653 no 2274 0.325145550251186 3280 4329390 SGTC_2083 5306046 65.942 µM -0.4564523184584 0.32239648184149 no 2275 0.324032375514693 3236 539837 SGTC_1733 st037357 54.9 µM -0.456990299583487 0.322191457458523 no 2276 0.3238390089365 3103 1272339 YGL099W LSG1 SGTC_63 0099-0242 26.702 µM -0.457183905151894 0.322117687688978 no 2277 0.323769432907796 3320 3898502 YLR359W ADE13 SGTC_1885 st057546 99.9 µM -0.459485386218837 0.321241288947319 no 2278 0.322942821993722 3366 702008 SGTC_3262 9137218 49.47 µM -0.459888372157759 0.321087935000558 no 2279 0.322798173427643 3216 17650664 SGTC_3240 9133527 49.47 µM -0.460855471129187 0.320720035631216 no 2280 0.322451150406144 3222 17617455 SGTC_2949 9072542 2.23 µM -0.461033041397399 0.320652504277692 no 2281 0.322387449864225 3292 16457352 SGTC_604 1000-0114 314 µM -0.461310256466042 0.320547089098852 no 2282 0.322288013742488 3338 1572745 SGTC_722 3534-0461 190 µM -0.46205535028828 0.320263827771019 no 2283 0.322020814103795 3256 658262 SGTC_2836 9010338 19.48 µM -0.462319843038534 0.320163301085682 no 2284 0.321925985924131 3197 2994051 SGTC_896 0964-0007 44.5 µM -0.463836526679052 0.319587104867219 no 2285 0.321382435704009 3311 6756758 SGTC_944 3370-0224 231 µM -0.46561777322759 0.318910955546536 no 2286 0.320744559384779 3236 4580514 SGTC_2925 9010536 32.5 µM -0.46605189496028 0.318746257016392 no 2287 0.320589177571541 3236 2994177 SGTC_1905 st060207 84.5 µM -0.466457498623094 0.318592410108384 no 2288 0.320444031413224 3191 1948547 SGTC_3040 9091894 49.47 µM -0.467396072409112 0.318236525669374 no 2289 0.320108266047162 3197 25236966 SGTC_2889 9059656 51.95 µM -0.467857207859253 0.318061735700386 no 2290 0.31994335339704 3297 3949838 SGTC_1395 3486-0190 4.35 µM -0.467999687880824 0.318007737897273 no 2291 0.319892406454932 3386 6748079 SGTC_2120 5538279 151.968 µM -0.471452043961866 0.316700531260953 no 2292 0.31865897904648 3270 2058197 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.474542180421542 0.315532413698705 no 2293 0.317556663206843 3305 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_259 usnic acid 108.925 µM -0.475216544388854 0.315277738386092 no 2294 0.317316318006736 3407 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1218 1348-1416 30.7 µM -0.475857895678066 0.315035611805815 no 2295 0.317087810064104 3248 6787668 SGTC_546 peri-Naphthalide 147 µM -0.476492160128609 0.314796238830254 no 2296 0.316861895677509 3240 223824 A penicillin ester. SGTC_111 0083-0039 52.457 µM -0.47692519287874 0.314632855877272 no 2297 0.316707695865779 3234 759313 SGTC_2545 solidagenone 89.61 µM -0.477668394648438 0.31435253096704 no 2298 0.316443121358402 3217 6708572 An anti ulcer agent SGTC_2664 lyso-paf C-16 73.48 µM -0.477743820782691 0.314324087304497 no 2299 0.316416275441813 3231 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3294 9122953 26.2835 µM -0.479437636367496 0.313685629570509 no 2300 0.315813662057477 3267 16459826 SGTC_517 1365-0151 113 µM -0.481168899116594 0.313033632874468 no 2301 0.315198231516055 3381 768657 SGTC_3333 9141820 12.094 µM -0.481669133291357 0.312845352477194 no 2302 0.315020503272421 3226 1939433 SGTC_1534 6-azauridine 81.6 µM -0.482527673455875 0.312522325047331 no 2303 0.3147155722876 3259 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1438 4092-1045 4 µM -0.483762456939373 0.3120579878254 no 2304 0.314277231019561 3252 1351342 SGTC_862 0452-0056 10.2 µM -0.484849409390368 0.311649489044804 no 2305 0.313891585558205 3326 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3024 9090631 49.47 µM -0.485702575381029 0.311329014217847 no 2306 0.313589028714136 3351 25236383 SGTC_143 4032-1194 15.74 µM -0.486633122625339 0.310979635627109 no 2307 0.313259173208002 3263 1806963 SGTC_1364 1653-0028 37.6 µM -0.486704103133011 0.310952992629166 no 2308 0.313234018537208 3304 5718652 SGTC_1681 tripelennamine 100 µM -0.487449151058277 0.310673393825403 no 2309 0.312970034621921 3350 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.489171858180507 0.310027321513718 no 2310 0.312360015661738 3438 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2405 ticlatone 3.52 µM -0.489184268496647 0.310022669357612 no 2311 0.312355622971054 3057 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_80 0159-0065 512.242 µM -0.489975057990928 0.309726295153731 no 2312 0.312075774262671 3327 1548079 SGTC_2924 9010168 62.78 µM -0.491283067368725 0.309236347370017 no 2313 0.311613127109366 3330 2993929 SGTC_2495 cafestol 54.53 µM -0.491572152537513 0.309128108969971 no 2314 0.311510916829076 3396 16667697 An anti-infammatory. SGTC_3353 9151644 39.2805 µM -0.492251068924982 0.308873976287778 no 2315 0.311270933150491 3368 4909158 SGTC_2950 9072895 21.46 µM -0.493311747371168 0.308477125156181 no 2316 0.310896164576616 3352 17332245 SGTC_2518 prenyletin 46.28 µM -0.494256552411724 0.30812381618574 no 2317 0.310562502529666 3333 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2621 lithochol-11-enic acid 100 µM -0.494773144949212 0.307930712015055 no 2318 0.310380131465478 3390 6708711 SGTC_1236 0330-0013 258 µM -0.495194346178268 0.307773304811271 no 2319 0.310231470590466 3275 4617066 SGTC_2648 atorvastatin 78.68 µM -0.495528373988549 0.307648500351917 no 2320 0.310113599181164 3370 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_762 1165-0429 115 µM -0.495564940957836 0.307634839006136 no 2321 0.310100696649098 3359 5967793 SGTC_902 1120-0002 2.07 µM -0.497086041331178 0.307066795503999 no 2322 0.309564188806887 3343 3280475 SGTC_759 3486-0358 89.3 µM -0.497375909979281 0.306958598689108 no 2323 0.309461995107567 3418 875103 SGTC_3010 9080089 71.4286 µM -0.499231523702548 0.306266368043713 no 2324 0.308808144543338 3345 17027233 SGTC_2528 xanthyletin 44.79 µM -0.499676061853063 0.306100637042025 no 2325 0.308651595350118 3252 65188 An natural product with antifungal activity of unknown mechanism. SGTC_584 0986-0246 15.4 µM -0.499834984201933 0.306041397850324 no 2326 0.30859563746336 3400 53315 YDR232W HEM1 SGTC_501 nsc-95397 161 µM -0.50074938022738 0.30570065022474 no 2327 0.308273757377272 3413 262093 SGTC_3323 9138564 53.9225 µM -0.501594938582238 0.305385704444545 no 2328 0.307976240229788 3421 43912313 YNL103W MET4 SGTC_2317 5986382 200 µM -0.501748786052564 0.30532841623364 no 2329 0.307922121204307 3347 877883 SGTC_2710 st078562 53.7235 µM -0.502962935716436 0.304876470474417 no 2330 0.307495165632289 3296 17250908 SGTC_295 k015-0027 31 µM -0.504865380781156 0.304168917401586 no 2331 0.306826695425127 3347 3887424 SGTC_989 1501-0895 10.3 µM -0.505754385951269 0.30383853161357 no 2332 0.306514541800171 3408 2830112 SGTC_1216 1165-0504 9.65 µM -0.507139530920854 0.303324082008571 no 2333 0.306028459850296 3412 6304004 SGTC_373 0844-0104 25.9 µM -0.50715021213661 0.303320116465858 no 2334 0.306024712870348 3389 5375804 SGTC_447 ml7 120 µM -0.508085447250162 0.30297298793268 no 2335 0.305696710293285 3386 4216 Selective myosin light chain kinase inhibitor. SGTC_1154 4088-0362 150 µM -0.508298633997054 0.302893884908595 no 2336 0.305621963940577 3355 6618304 SGTC_83 0170-0301 39.027 µM -0.508759373968314 0.302722958756967 no 2337 0.305460449522211 3346 3089716 SGTC_2606 farnesol 9.78 µM -0.50897853652606 0.302641668600309 no 2338 0.30538363441066 3433 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2118 5526350 200 µM -0.510212862531166 0.302184024307696 no 2339 0.304951170929343 3354 743594 SGTC_3128 9127691 49.47 µM -0.511437136276188 0.301730414121422 no 2340 0.304522498346837 3364 41316314 SGTC_1819 st053448 58.6 µM -0.511920476430962 0.301551414303943 no 2341 0.304353333355437 3265 2857616 SGTC_1397 3532-0190 20.1 µM -0.512380474705227 0.301381103283937 no 2342 0.304192376694285 3248 5322280 SGTC_2598 perillyl alcohol 100 µM -0.513344988882463 0.30102413957982 no 2343 0.303855009518815 3411 10819 An apoptosis inducer. SGTC_195 4234-0266 16.654 µM -0.513514616313232 0.300961380705391 no 2344 0.303795694601381 3302 2303354 SGTC_2419 paclitaxel 166.5 µM -0.51407850178237 0.300752796383297 no 2345 0.303598553609619 3330 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3159 9100096 49.47 µM -0.514257635505409 0.300686547493423 no 2346 0.303535938310231 3325 25236875 SGTC_2519 cryptotanshinone 88.04 µM -0.515146814677434 0.300357800562683 no 2347 0.303225215567878 3419 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3192 9110362 49.47 µM -0.515498169770275 0.300227942496765 no 2348 0.303102474106876 3427 16649480 SGTC_2903 5923464 63.88 µM -0.517714955775748 0.299409221835519 no 2349 0.302328580947621 3409 2876576 SGTC_2173 5763948 167 µM -0.518097148085345 0.299268169976682 no 2350 0.302195244977624 3384 2867177 SGTC_1396 3511-0007 98.6 µM -0.519278505361081 0.298832369099505 no 2351 0.301783270177135 3370 X1396 SGTC_338 4055-0136 114 µM -0.519509592518469 0.298747155136423 no 2352 0.301702712668673 3316 2900563 SGTC_2716 st080858 38.6235 µM -0.521025232033038 0.298188533297101 no 2353 0.301174597143445 3414 5296050 SGTC_407 eburnamonine 100 µM -0.521888892882889 0.297870425287398 no 2354 0.30087384608716 3315 3195 SGTC_290 2043-6722 48.1 µM -0.522225173835179 0.297746606425655 no 2355 0.300756780228796 3391 773758 YLR208W SEC13 SGTC_690 glyoxal 20.3 µM -0.523925256433645 0.297120994645199 no 2356 0.300165263683274 3352 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1466 k213-0079 57.5 µM -0.523944520791174 0.297113909017527 no 2357 0.300158563973478 3380 3657981 SGTC_697 0508-1955 564 µM -0.525949319923932 0.296376946193599 no 2358 0.299461710013356 3443 6243113 SGTC_787 4152-0075 138 µM -0.526878725922471 0.296035581706042 no 2359 0.29913890410172 3352 9566539 SGTC_3207 9114163 49.47 µM -0.528439813629616 0.29546261134953 no 2360 0.298597055111664 3527 849233 SGTC_1518 st038567 90.8 µM -0.528533088452036 0.295428392586719 no 2361 0.298564693829369 3407 77966 SGTC_3186 9110464 49.47 µM -0.528681872940867 0.295373813344085 no 2362 0.298513077018728 3444 17018021 SGTC_838 0109-0203 71.4 µM -0.531689876758458 0.294271371017896 no 2363 0.297470402212933 3381 759422 SGTC_458 nppb 133 µM -0.532773483256403 0.293874692188564 no 2364 0.297095195819165 3497 4549 A chloride channel blocker. SGTC_2956 9076196 2.52 µM -0.534055028315743 0.293405872926667 no 2365 0.296651731325002 3465 16423868 SGTC_3031 9088762 49.47 µM -0.534616472697861 0.293200592606313 no 2366 0.296457545254204 3321 205253 SGTC_1240 0356-0016 42.1 µM -0.534804843804999 0.293131733597665 no 2367 0.296392406627789 3336 4305613 SGTC_1708 st033234 31.827 µM -0.53514618124804 0.293006976896254 no 2368 0.296274389044906 3476 674664 SGTC_1986 st071812 45 µM -0.535358420015915 0.292929417376136 no 2369 0.296201018258043 3419 11838594 SGTC_3317 9138495 8.753 µM -0.535437921124284 0.292900367324426 no 2370 0.296173536929022 3426 17020139 SGTC_782 0083-0095 30.5 µM -0.538259011549032 0.291870395257736 no 2371 0.295199122351367 3425 3591729 An indicator and reagent. SGTC_1035 k081-0041 55.2 µM -0.538463415223601 0.291795833651394 no 2372 0.295128577979287 3467 731709 SGTC_2859 9028643 45.46 µM -0.538743577351935 0.291693651580693 no 2373 0.295031900250188 3383 17151580 SGTC_3080 9117754 49.47 µM -0.539674752886357 0.291354148680926 no 2374 0.294710677122736 3519 9550191 SGTC_1636 st007707 68.9 µM -0.540653866894955 0.290997366605322 no 2375 0.29437309095567 3494 403051 SGTC_806 3966-4455 5.86 µM -0.54114082579857 0.290819998336164 no 2376 0.29420526017349 3335 714982 SGTC_463 ikarugamyin 104 µM -0.541426568517245 0.290715943907049 no 2377 0.294106799298122 3421 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3156 9099931 49.47 µM -0.541771276531392 0.290590440190951 no 2378 0.293988040504736 3324 18111053 SGTC_1469 k284-2957 126 µM -0.543199700816058 0.290070639802673 no 2379 0.293496156281109 3397 23884841 SGTC_1881 5652484 16 µM -0.543825373020466 0.289843096427838 no 2380 0.29328082339995 3422 2255129 SGTC_3351 9150312 21.596 µM -0.544036855116476 0.289766203926204 no 2381 0.293208055765143 3397 4904905 SGTC_769 0302-0231 76 µM -0.544164841206946 0.289719674278591 no 2382 0.293164021847625 3448 571869 YER009W NTF2 SGTC_502 l-744,832 89.3 µM -0.544166869381086 0.289718936959281 no 2383 0.293163324074191 3422 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_43 0570-0105 72.5 µM -0.544277768557691 0.289678622183567 no 2384 0.293125171471809 3431 1114046 YDL195W SEC31 SGTC_1512 0259-0544 12.2 µM -0.544871640055708 0.289462779045454 no 2385 0.292920901274349 3420 18476 SGTC_2788 5282734 71.43 µM -0.545056776655136 0.289395506427964 no 2386 0.292857234527454 3472 743706 SGTC_1262 0737-0114 49.6 µM -0.545147916302256 0.289362391943285 no 2387 0.292825894813915 3488 765919 SGTC_2877 9040724 71.43 µM -0.545684964836014 0.289167298040689 no 2388 0.292641254371134 3469 6463895 SGTC_1010 4112-3296 15.2 µM -0.545715066367064 0.289156364872298 no 2389 0.292630906888678 3493 704384 SGTC_1965 Pectolinarigenin 58.4 µM -0.547179305726489 0.288624773747647 no 2390 0.29212777601696 3360 5320438 An anti-inflammatory. SGTC_1184 1269-1718 139 µM -0.551006540227435 0.287237477347487 no 2391 0.290814595590357 3468 5403821 SGTC_3045 9092950 49.47 µM -0.552740924229781 0.28660983845811 no 2392 0.290220413002595 3498 44120432 SGTC_955 1216-0110 33 µM -0.552946278774865 0.28653556784284 no 2393 0.290150098265017 3416 3619719 SGTC_3151 9099821 49.47 µM -0.553121296095993 0.286472276504498 no 2394 0.290090177492729 3424 17174189 SGTC_175 3793-3120 23.7 µM -0.554273310494656 0.286055840319485 no 2395 0.289695906521703 3354 5322297 SGTC_740 k014-0057 261 µM -0.554356730707131 0.286025696317492 no 2396 0.289667366152983 3428 4012779 SGTC_2860 9025725 38.96 µM -0.554566084819853 0.285950052585964 no 2397 0.289595746116308 3325 40546248 SGTC_1590 st077108 57.8 µM -0.554994593871413 0.285795253550976 no 2398 0.289449179109143 3442 5489485 SGTC_3162 9099653 49.47 µM -0.555661394067527 0.285554451053987 no 2399 0.289221176446185 3444 25237511 SGTC_592 k241-0073 46.5 µM -0.556261313924386 0.285337883710973 no 2400 0.28901611472408 3478 4230158 SGTC_102 gallobenzophenone 83.616 µM -0.556489601891126 0.285255493727086 no 2401 0.288938100397474 3514 70837 SGTC_1612 st002233 45.4 µM -0.556900752745813 0.285107136437222 no 2402 0.288797620149947 3470 1035021 SGTC_18 0111-0177 500 nM -0.55740232489085 0.28492620187234 no 2403 0.288626288697889 3488 721752 SGTC_2132 5317594 122.667 µM -0.558874091099822 0.284395600846682 no 2404 0.288123826335559 3391 794577 SGTC_1293 1000-1278 195 µM -0.558901018907272 0.284385897235744 no 2405 0.288114637003025 3504 678847 SGTC_3307 9126885 69.2785 µM -0.559131303306504 0.284302919213869 no 2406 0.288036056234476 3360 24824909 SGTC_112 phenothiazine 287.218 µM -0.559153678895254 0.284294857269419 no 2407 0.2880284214716 3470 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2450 5739737 12.93 µM -0.559783061932774 0.284068134780296 no 2408 0.287813709156945 3458 2262825 SGTC_220 paclitaxel 373.376 µM -0.561643202244255 0.283398562939084 no 2409 0.287179569658171 3450 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.561913888908561 0.283301190287203 no 2410 0.287087345157499 3563 16725076 SGTC_119 0121-0043 24.815 µM -0.561939824301499 0.283291861530721 no 2411 0.287078509556491 3516 1092378 SGTC_861 0443-0273 110 µM -0.562821057938507 0.282974976312003 no 2412 0.286778369761202 3441 6149169 SGTC_2440 5628896 157.78 µM -0.562995434811861 0.282912291828442 no 2413 0.286718996289945 3422 5522048 SGTC_770 0389-1121 67.2 µM -0.563814641451307 0.282617895121435 no 2414 0.286440143170873 3538 6753108 SGTC_950 1165-0508 94.1 µM -0.564361969418088 0.28242128501681 no 2415 0.286253907699808 3421 6148369 SGTC_3297 9117502 71.43 µM -0.565107701019224 0.282153510662888 no 2416 0.286000255386151 3454 7453720 SGTC_3350 9150499 3.57 µM -0.565364097373614 0.282061473116755 no 2417 0.285913069700631 3447 4910996 YPR165W RHO1 SGTC_677 0929-0063 136 µM -0.565397662843622 0.282049425328125 no 2418 0.285901656946001 3430 1539583 SGTC_2630 antimycin a 100 µM -0.565526308798079 0.282003252215408 no 2419 0.285857917430879 3420 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1900 st060200 72.8 µM -0.5658252455608 0.281895973039594 no 2420 0.285756291474679 3431 688945 SGTC_1342 1486-1464 234 µM -0.566521682515526 0.281646119608179 no 2421 0.285519598809256 3462 3253938 SGTC_2124 5246320 200 µM -0.567278097824676 0.281374869400719 no 2422 0.285262627540493 3451 579342 SGTC_1351 1496-0003 46.5 µM -0.568420147626743 0.280965569868223 no 2423 0.284874856479819 3475 3891978 SGTC_748 act1.228 77.9 µM -0.568429523587403 0.280962210806349 no 2424 0.284871674011468 3447 4421505 YNR035C ARC35 SGTC_2595 hexamethylquercetagetin 100 µM -0.568551276512582 0.280918592973573 no 2425 0.284830349137799 3388 386331 SGTC_218 alverine citrate 93.75 µM -0.570541975125883 0.280205892322825 no 2426 0.284155080499869 3492 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3276 9139060 49.47 µM -0.570595027832199 0.280186910630208 no 2427 0.284137094869298 3488 4870619 SGTC_280 3448-3607 3.04 µM -0.573349133565064 0.27920237757092 no 2428 0.283204161955398 3482 626179 SGTC_1137 ixabepilone 100 µM -0.57547080853324 0.278445073238048 no 2429 0.282486463811147 3503 154225 A novel microtubule stabilizer. SGTC_2235 salicylic acid 500 µM -0.576297370362151 0.278150313874336 no 2430 0.282207099996331 3461 338 A COX inhibitor and kinase inhibitor. SGTC_1737 st035557 69.7 µM -0.577065851122371 0.277876403328994 no 2431 0.281947485937929 3418 5716916 SGTC_610 4215-0184 155 µM -0.577609230997022 0.277682805269446 no 2432 0.281763986647472 3490 5605015 SGTC_1561 5-methoxyflavone 52.9 µM -0.579936791096485 0.276854276992868 no 2433 0.280978622063767 3464 94525 SGTC_2264 7948757 110.76 µM -0.580586697640694 0.276623149886086 no 2434 0.280759519886572 3422 2971411 SGTC_1238 0333-0287 48.8 µM -0.58069136786792 0.276585934721213 no 2435 0.280724240270877 3447 7226 SGTC_2061 5245884 80.95 µM -0.581268668303209 0.276380721502127 no 2436 0.28052969684976 3461 573863 SGTC_1283 0922-0125 16.4 µM -0.581720236255386 0.2762202545318 no 2437 0.280377569282546 3457 3360884 SGTC_3044 9093193 49.47 µM -0.582968976118002 0.275776746644645 no 2438 0.27995709260444 3470 25236277 SGTC_3150 9097574 49.47 µM -0.583361832260727 0.275637290548907 no 2439 0.279824873025938 3488 17217476 SGTC_1996 st072960 66.8 µM -0.584879940325107 0.27509871855116 no 2440 0.279314223782372 3527 1719405 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.585526015335817 0.274869670903145 no 2441 0.279097039590186 3556 165506 SGTC_507 nimesulide 162 µM -0.586186751783868 0.27463552271197 no 2442 0.278875011779565 3556 4495 A COX2 inhibitor. SGTC_1242 0402-0103 60.1 µM -0.586502997962082 0.274523487932105 no 2443 0.278768773736757 3467 432868 SGTC_866 0495-0101 262 µM -0.586951168742061 0.274364755587273 no 2444 0.278618251399841 3392 635694 SGTC_3304 9125678 46.087 µM -0.587213846186449 0.274271742012493 no 2445 0.278530047130956 3462 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2089 5281248 129.67 µM -0.589646207594275 0.273411187920061 no 2446 0.277713933013834 3522 2737878 SGTC_1788 fluconazole 20 µM -0.591087647212586 0.272901847330862 no 2447 0.277230848080302 3489 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_682 0kpi-0099 17 µM -0.591293076414284 0.272829296124701 no 2448 0.277162033895304 3519 1714895 YML126C ERG13 SGTC_108 0509-0257 621.132 µM -0.591889824063656 0.27261859768856 no 2449 0.276962184199843 3480 536624 SGTC_1621 st003705 32.4 µM -0.592430840458559 0.27242764655896 no 2450 0.276781059795403 3534 24207032 SGTC_2553 4-methylesculetin 85.09 µM -0.593258786339022 0.272135552662032 no 2451 0.2765039879749 3480 5319502 SGTC_1879 gemcitabine 100 µM -0.593896824755187 0.271910563142978 no 2452 0.276290561446291 3492 60750 A nucleoside analog which inhibits DNA replication. SGTC_901 1112-0062 60.1 µM -0.595371985706319 0.271390736226747 no 2453 0.275797423594854 3501 1908457 SGTC_1108 betulinic acid 729.144 nM -0.598296948916208 0.270361484929587 no 2454 0.274820906039112 3487 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.59958489631316 0.269908894827389 no 2455 0.274391457734223 3477 2374 Ca(2+)-ATPase inhibitor. SGTC_58 0957-0393 9 µM -0.600089773445995 0.269731582418412 no 2456 0.274223203834872 3507 6997992 SGTC_2221 6807166 181.081 µM -0.601895214920006 0.269097990639371 no 2457 0.273621944819431 3485 674925 SGTC_879 0831-1030 162 µM -0.603345085463224 0.268589722235757 no 2458 0.273139572897294 3557 1549252 SGTC_1431 4049-0260 9.09 µM -0.605283451994695 0.267910960633858 no 2459 0.2724953373583 3512 3854841 SGTC_2423 st077119 87.2 µM -0.606877082868197 0.267353563615191 no 2460 0.271966243937762 3488 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1845 st056753 3.01 µM -0.607293850244694 0.267207889353308 no 2461 0.271827959418514 3459 5375839 SGTC_2258 7960471 200 µM -0.607335651110494 0.267193280750966 no 2462 0.271814091711292 3478 2974708 SGTC_68 0986-0284 82.829 µM -0.607378187966147 0.267178415348097 no 2463 0.271799980196093 3510 423278 YIL048W NEO1 SGTC_568 1193-0097 7.48 µM -0.607592034216344 0.267103688583359 no 2464 0.271729042662213 3466 3646150 SGTC_959 1222-0044 107 µM -0.608117746989334 0.266920027565025 no 2465 0.271554691283616 3525 6083612 SGTC_534 k292-0788 63.4 µM -0.608498778526217 0.266786951720046 no 2466 0.271428357922366 3579 4146317 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.609145962819725 0.266560998483122 no 2467 0.271213847095205 3501 15053 SGTC_1560 lithocholic acid 53.1 µM -0.611442723057466 0.265759906159271 no 2468 0.270453263099969 3490 9903 A bile acid which acts as a detergent. SGTC_1859 st055998 20 µM -0.611712986687176 0.265665720599751 no 2469 0.270363834046026 3571 676301 SGTC_2896 9052656 71.43 µM -0.615080944691898 0.264493425097104 no 2470 0.269250632788151 3511 6469436 SGTC_1985 st071382 65.5 µM -0.615632353718631 0.264301745530162 no 2471 0.269068596432202 3576 6123237 SGTC_2610 ononetin 44.17 µM -0.61564192591319 0.264298418690057 no 2472 0.26906543691441 3512 259632 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.616755988150139 0.263911369281458 no 2473 0.268697842886451 3515 6708561 SGTC_813 k007-0158 173 µM -0.618668787921469 0.263247495698677 no 2474 0.268067287894024 3537 6523916 SGTC_972 1319-0219 195 µM -0.618861570372285 0.263180634224565 no 2475 0.268003778448219 3496 23903702 SGTC_1969 st069479 40.1 µM -0.619197457106221 0.263064161558699 no 2476 0.267893143425928 3542 3895485 SGTC_3346 9158254 43.5805 µM -0.619977326765087 0.262793834225324 no 2477 0.267636357186715 3509 17639500 SGTC_1717 st033143 58.0435 µM -0.621588612515177 0.262235762312056 no 2478 0.267106205379407 3592 674616 SGTC_2684 capsaicin 100 µM -0.621779467397599 0.262169699596405 no 2479 0.267043444665408 3562 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1920 st075728 45.7 µM -0.622133258194865 0.262047260626273 no 2480 0.266927123809119 3578 3400306 SGTC_262 fenpropimorph 62.5 µM -0.623995469117118 0.26140327518365 no 2481 0.266315280324054 3521 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1191 1487-1166 10.6 µM -0.625142568241753 0.261006992950266 no 2482 0.265938745800906 3578 3955771 SGTC_196 k015-0023 18.111 µM -0.625454618966133 0.260899243914012 no 2483 0.265836362046517 3549 5211998 SGTC_844 0330-0132 15.3 µM -0.626110106373708 0.260672983003516 no 2484 0.265621361887918 3571 2828079 SGTC_2693 st077581 40.7 µM -0.628096050185427 0.259988092630765 no 2485 0.2649705102069 3566 25238761 SGTC_2940 9060638 45.86 µM -0.628117915229098 0.259980557224043 no 2486 0.264963348907406 3541 4027022 SGTC_3134 9127454 49.47 µM -0.628484380105073 0.259854278248993 no 2487 0.264843337958715 3650 24262820 SGTC_2842 9000675 19.48 µM -0.629509558974347 0.259501183255699 no 2488 0.264507756330685 3513 2989072 SGTC_3259 9138485 49.47 µM -0.629922318455452 0.259359089469648 no 2489 0.264372704932418 3700 17646153 SGTC_1017 4239-0030 168 µM -0.630153104176596 0.259279658264034 no 2490 0.264297209106223 3502 1149593 SGTC_489 paxilline 115 µM -0.630320695793114 0.259221984914645 no 2491 0.264242392545182 3555 105008 A toxic potassium channel blocker. SGTC_3230 9131665 49.47 µM -0.631017996828912 0.258982093722902 no 2492 0.264014378606406 3501 15943720 SGTC_2027 5150920 200 µM -0.631263761594404 0.258897571098045 no 2493 0.263934038664873 3531 786715 SGTC_2955 9076254 12.21 µM -0.632194575326165 0.258577578074152 no 2494 0.263629870793359 3501 16459619 SGTC_2912 7964298 10.93 µM -0.633495654502015 0.258130639495316 no 2495 0.263205008844849 3578 2975850 SGTC_2202 7226349 200 µM -0.634384345836767 0.257825592202344 no 2496 0.262915011590426 3525 844334 SGTC_859 0439-0102 54.6 µM -0.63709046169179 0.256897859268726 no 2497 0.262032960584965 3597 610143 SGTC_903 1134-0042 114 µM -0.637351627534386 0.256808416243537 no 2498 0.261947914630341 3538 701009 SGTC_1461 k072-0203 53.8 µM -0.637562466764593 0.25673622069991 no 2499 0.261879267342586 3522 5418714 SGTC_3199 9111318 49.47 µM -0.639058259296373 0.256224335147583 no 2500 0.261392516284158 3535 8548020 SGTC_1368 1852-0141 284 µM -0.641039954612802 0.255546985797565 no 2501 0.260748362225959 3559 2838987 SGTC_1418 3966-3099 2.4 µM -0.642915908926976 0.254906641948585 no 2502 0.260139332958586 3583 740335 SGTC_3254 9136651 49.47 µM -0.643158893345011 0.254823762391454 no 2503 0.260060501650106 3574 16454030 SGTC_992 3909-8734 162 µM -0.643732105793746 0.254628301255208 no 2504 0.259874583445465 3573 4288319 SGTC_1504 k297-0033 30 µM -0.643763187829115 0.254617704759656 no 2505 0.259864504123835 3476 4388117 SGTC_1170 0310-0127 64.8 µM -0.644476513000327 0.254374581247294 no 2506 0.259633241574897 3558 774975 SGTC_34 0469-0683 81.75 µM -0.64727634429451 0.253421488571452 no 2507 0.258726554356103 3569 3690923 SGTC_1741 st038134 10.228 µM -0.647716979467838 0.25327166272977 no 2508 0.258584010065848 3660 1272587 SGTC_888 0916-0002 6.97 µM -0.64872618170103 0.25292868689944 no 2509 0.258257689162589 3631 2802138 YIL048W NEO1 SGTC_1697 st025554 27.742 µM -0.650327382372719 0.2523850232857 no 2510 0.2577403865997 3580 1269519 SGTC_305 1682-2595 20.8 µM -0.65039068678399 0.252363541889312 no 2511 0.257719945796812 3595 226033 SGTC_2815 7968870 71.43 µM -0.650697177386371 0.252259552560156 no 2512 0.257620992810205 3602 2977326 YHR190W ERG9 SGTC_1987 st072290 61.9 µM -0.65208311112442 0.251789600732264 no 2513 0.257173779255625 3584 54697379 SGTC_1324 1418-0026 34.4 µM -0.653248852135583 0.251394671564439 no 2514 0.256797930349436 3622 1372513 SGTC_1196 1588-0294 184 µM -0.653599982361402 0.251275780033743 no 2515 0.256684777800632 3582 6144269 SGTC_2674 ligustilide 100 µM -0.655090193483069 0.250771530500617 no 2516 0.256204842767003 3580 5319022 A signalling regulator. SGTC_2865 9030313 51.95 µM -0.655200906580707 0.250734089398254 no 2517 0.256169205362667 3544 42562754 SGTC_472 calcifediol 10 µM -0.655267369354122 0.2507116143513 no 2518 0.256147812923031 3588 5283731 A vitamin D metabolite. SGTC_358 0075-0058 9.45 µM -0.65531843220485 0.250694347665903 no 2519 0.256131377904823 3633 1069125 SGTC_2892 9047358 58.44 µM -0.656468897014162 0.250305489891606 no 2520 0.255761236722226 3581 6466771 SGTC_1662 st014054 52 µM -0.657226416067307 0.250049622722041 no 2521 0.255517671265875 3604 2838777 SGTC_1759 st043059 70 µM -0.657374326342383 0.249999679274407 no 2522 0.255470127749887 3587 669426 SGTC_2106 5357045 167.29 µM -0.662403588133964 0.248304651120684 no 2523 0.253856302381281 3618 668842 SGTC_2274 7947094 46.08 µM -0.664038019671821 0.247755115532054 no 2524 0.253332988820668 3632 2971028 SGTC_85 0868-0259 160.055 µM -0.664056868449879 0.247748781904833 no 2525 0.253326957113699 3549 83173 SGTC_971 1315-0384 26.7 µM -0.664459285845208 0.247613580942077 no 2526 0.253198199469102 3617 6769120 SGTC_2966 9084041 48.03 µM -0.664694286373548 0.247534645584137 no 2527 0.253123024518212 3537 17741380 SGTC_555 4296-0685 37 µM -0.665813646849124 0.247158843288037 no 2528 0.252765110489285 3595 2908540 YHR072W ERG7 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.667463433496605 0.246605518055101 no 2529 0.252238079586363 3626 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3256 9138902 49.47 µM -0.670900959185411 0.24545473431391 no 2530 0.25114181263784 3639 17228773 SGTC_2165 5727197 32.143 µM -0.671972709684084 0.245096534347272 no 2531 0.250800535011353 3758 1361712 SGTC_638 3970-0837 4.09 µM -0.672289667742393 0.244990654662632 no 2532 0.250699653088322 3625 4118451 YLR208W SEC13 SGTC_1944 st076371 56.9 µM -0.672462131408313 0.24493305359855 no 2533 0.250644770103347 3607 24208455 SGTC_818 4072-2707 53.5 µM -0.672652549260478 0.244869464489387 no 2534 0.250584180964062 3583 882871 SGTC_1505 k297-0037 20.6 µM -0.673244460186577 0.244671855482064 no 2535 0.2503958901267 3625 4089396 SGTC_2306 7482397 179.52 µM -0.67332998727493 0.244643309431334 no 2536 0.250368689588158 3644 891448 SGTC_1422 4031-0024 15.5 µM -0.674330114478945 0.244309633932228 no 2537 0.250050731221988 3599 782427 SGTC_1443 4112-3303 14 µM -0.677481001407695 0.243259999619605 no 2538 0.249050410112075 3645 704433 SGTC_3285 9112818 20.8695 µM -0.678358232542671 0.242968207751027 no 2539 0.248772292398156 3674 17017947 YPR165W RHO1 SGTC_3137 9097352 49.47 µM -0.678843573326356 0.242806851081881 no 2540 0.248618490844358 3726 44120435 SGTC_3042 9091578 49.47 µM -0.679390298419867 0.242625156032618 no 2541 0.248445297657484 3603 25236497 SGTC_3257 9139206 32.98 µM -0.680189217464107 0.242359780936833 no 2542 0.24819232940053 3606 4910041 SGTC_1683 st010134 710 nM -0.680535109291659 0.242244935651851 no 2543 0.248082849473628 3664 3818134 SGTC_26 0302-0163 425.158 µM -0.68065807259869 0.242204115672032 no 2544 0.248043935959363 3661 3100915 SGTC_2483 5729050 27.16 µM -0.68078884056793 0.242160708879441 no 2545 0.248002556120436 3679 2865180 SGTC_1530 rhein 70.4 µM -0.681056308119455 0.24207193950578 no 2546 0.247917930933067 3684 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3001 9076041 71.4286 µM -0.681268589737001 0.242001498264581 no 2547 0.247850777227648 3654 16004211 SGTC_382 3229-0966 23.2 µM -0.682188221878635 0.241696465903095 no 2548 0.247559970644831 3660 5722370 SGTC_2237 6667747 47.222 µM -0.682298833645587 0.24165979120299 no 2549 0.247525005215976 3583 729940 YDL015C TSC13 SGTC_1816 st051957 91.6 µM -0.682523275300029 0.241585384080154 no 2550 0.247454065189376 3656 674121 SGTC_1322 1348-1070 12 µM -0.682724517308052 0.241518678706122 no 2551 0.247390467192269 3626 6758089 SGTC_1128 3448-9350 235 µM -0.683226714604058 0.241352259787555 no 2552 0.24723179717579 3647 619386 SGTC_2953 9074162 66.49 µM -0.685432732525825 0.240621964640205 no 2553 0.246535447391597 3601 16451992 SGTC_513 4245-1575 41.7 µM -0.687943989922587 0.239792087208528 no 2554 0.245744026650443 3636 719745 SGTC_1134 3477-0009 42.5 µM -0.688232026388395 0.239697001764388 no 2555 0.245653339470537 3694 3973534 SGTC_445 e6 berbamine 66 µM -0.688578380960389 0.239582691832731 no 2556 0.245544314861598 3706 6610268 A calcium/calmodulin antagonist. SGTC_148 3253-0744 288.01 µM -0.688809483206972 0.239506436024037 no 2557 0.245471583546343 3629 6893655 SGTC_1910 st062352 60.4 µM -0.689520158532972 0.23927202061736 no 2558 0.2452479959959 3621 2245730 SGTC_559 1550-0661 158 µM -0.690023254382 0.239106150858185 no 2559 0.245089781819106 3675 5830875 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.691155053695476 0.238733228583284 no 2560 0.244734052996202 3619 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1783 st039459 87.517 µM -0.691480499098728 0.238626054869563 no 2561 0.244631815750969 3713 729761 SGTC_427 1354-0053 47.3 µM -0.691883904480526 0.238493244402474 no 2562 0.244505119652215 3708 6813657 SGTC_1637 st007924 17.4 µM -0.692844360452793 0.238177202810329 no 2563 0.244203614970648 3652 683336 SGTC_2647 atorvastatin 60.16 µM -0.693567482575019 0.237939408303448 no 2564 0.243976746063532 3656 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2399 5884133 200 µM -0.693684836191881 0.237900829528435 no 2565 0.243939938822795 3680 722445 SGTC_2071 5230951 39.92 µM -0.694711910476209 0.237563335997652 no 2566 0.243617931176363 3708 1799272 SGTC_2798 7813637 45.45 µM -0.695017638801034 0.237462925358432 no 2567 0.243522123786782 3657 956368 SGTC_1259 0671-0132 43 µM -0.696684051413625 0.23691603369423 no 2568 0.243000270929012 3620 X1259 SGTC_3079 9117512 49.47 µM -0.697651305694428 0.236598913192313 no 2569 0.242697643791017 3688 7185044 SGTC_1458 k015-0034 6.33 µM -0.697826625519153 0.236541458478878 no 2570 0.242642812912608 3672 3598957 SGTC_2748 diazoxide 86.69 µM -0.698147518421904 0.236436317358568 no 2571 0.242542471758651 3618 3019 A potassium channel activatior. SGTC_377 3970-0964 33.1 µM -0.698506534424759 0.236318715634022 no 2572 0.242430236396983 3667 16481235 SGTC_995 3931-2021 34.6 µM -0.698997802775078 0.236157844632432 no 2573 0.242276701991493 3677 730143 SGTC_3143 9086658 49.47 µM -0.700573641041478 0.235642227087329 no 2574 0.241784566519578 3739 25236626 SGTC_1809 st050081 57.6 µM -0.701182071903404 0.235443313531168 no 2575 0.241594698374197 3730 5036894 SGTC_1288 0973-0013 65.5 µM -0.702115398454025 0.235138362402078 no 2576 0.241303600043911 3703 4315430 SGTC_1428 4049-0204 61.7 µM -0.702668362049268 0.234957792398357 no 2577 0.241131224334505 3715 X1428 SGTC_2831 7999036 19.48 µM -0.70377154009229 0.234597779141541 no 2578 0.24078752999492 3681 2988270 SGTC_1507 4075-3230 155 µM -0.70535188762113 0.234082577472579 no 2579 0.240295638640936 3611 659771 SGTC_535 2293-4129 48.2 µM -0.707434791212569 0.233404498094479 no 2580 0.239648161326127 3697 396118 YIL048W NEO1 SGTC_2874 9043904 71.43 µM -0.708230425188427 0.233145771145648 no 2581 0.239401087494907 3670 4463428 SGTC_891 0929-0073 133 µM -0.708251149997287 0.233139033910503 no 2582 0.239394653533448 3719 5603632 SGTC_2794 7785382 27.27 µM -0.70882499277559 0.232952531638614 no 2583 0.239216543092249 3656 2205081 SGTC_292 k038-0015 474 µM -0.709484804518882 0.232738191405934 no 2584 0.239011838959955 3680 46368540 SGTC_2206 7254556 146.969 µM -0.711162418864273 0.232193711308881 no 2585 0.23849179693646 3689 4398905 SGTC_2622 2-methoxyxanthone 59.94 µM -0.71178594093633 0.231991524212438 no 2586 0.238298669962412 3705 71034 A hepatoprotective. SGTC_3331 9141060 1.957 µM -0.711798247776903 0.231987534507512 no 2587 0.238294858958204 3690 4906567 YPR165W RHO1 SGTC_2897 9048598 12.99 µM -0.712368437201992 0.231802728996458 no 2588 0.238118327561223 3699 6467404 SGTC_488 nitrendipine 139 µM -0.71253836356024 0.23174766960898 no 2589 0.238065732001579 3721 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2069 5228469 200 µM -0.712557138358165 0.231741586662695 no 2590 0.238059921221931 3667 2835210 SGTC_364 0083-0097 67.7 µM -0.71324483066809 0.231518838901819 no 2591 0.237847134775427 3732 5207356 SGTC_352 k048-0007 5.11 µM -0.714364334939872 0.231156480036801 no 2592 0.237500959853575 3697 6811911 SGTC_3213 9129884 49.47 µM -0.71540694226453 0.230819295814854 no 2593 0.237178812002756 3661 17190742 SGTC_1158 4092-0494 91.8 µM -0.715921111813398 0.230653112097362 no 2594 0.237020030821746 3821 1148199 SGTC_3098 9119039 49.47 µM -0.716632084393452 0.23042343022952 no 2595 0.236800570985415 3710 17161528 SGTC_2917 7979103 53.79 µM -0.716949646847182 0.230320882031102 no 2596 0.236702583340749 3722 2980565 SGTC_1600 coumarin 106 71.1 µM -0.71911475492301 0.229622399530325 no 2597 0.236035108425002 3780 100336 A hepatotoxic, DNA x-linker. SGTC_2236 dapsone 200 µM -0.721506602370098 0.228852150378624 no 2598 0.235298939984478 3723 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1112 tnp00069 1.16933 µM -0.724027049737452 0.228042059656123 no 2599 0.23452456433629 3766 145826 SGTC_1084 voriconazole 435 nM -0.724757643115779 0.227807543310233 no 2600 0.234300362573893 3720 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1749 st037932 54.2 µM -0.72682910099131 0.227143355521571 no 2601 0.233665326822451 3739 594497 SGTC_1143 3454-2408 5.08 µM -0.728437511982501 0.226628391822954 no 2602 0.233172903720458 3669 X1143 SGTC_12 0849-0099 9.267 µM -0.729510680432727 0.226285163153177 no 2603 0.232844668479913 3652 6071388 SGTC_1190 1486-1332 13 µM -0.730527932564736 0.22596008932991 no 2604 0.232533772733494 3718 4150046 SGTC_2174 5790901 200 µM -0.73139731235095 0.225682479067486 no 2605 0.232268253218063 3755 786020 SGTC_1398 3558-0053 112 µM -0.732499568456155 0.225330784342335 no 2606 0.231931853009977 3647 4532369 SGTC_1572 epiandrosterone 68.9 µM -0.73350396127898 0.225010585083531 no 2607 0.231625556342079 3667 441302 A steroid. SGTC_3152 9099253 49.47 µM -0.735051408771044 0.224517765674627 no 2608 0.231154092866568 3704 25236131 SGTC_1634 st006576 41 µM -0.735665972767218 0.224322214011042 no 2609 0.230967001268795 3706 3915356 SGTC_745 0469-0705 296 µM -0.735864717232777 0.224258995059134 no 2610 0.23090651562456 3802 3486736 SGTC_1029 k015-0030 64.7 µM -0.736707214550719 0.223991116068115 no 2611 0.230650209271607 3804 2208316 SGTC_2057 5236571 38.335 µM -0.737608147546468 0.223704858225608 no 2612 0.230376301454383 3727 54684039 YBR257W POP4 SGTC_3347 9188721 44.724 µM -0.738761922488732 0.223338567604043 no 2613 0.23002578863772 3763 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1984 st072354 53.1 µM -0.739796820393742 0.22301030761342 no 2614 0.229711644313881 3673 5762938 SGTC_1286 0929-0070 131 µM -0.739907163975059 0.222975323873848 no 2615 0.22967816358735 3817 1420408 SGTC_1826 st055655 41.6 µM -0.740568186619321 0.222765816257114 no 2616 0.229477651677156 3777 676168 SGTC_2982 9019404 25.97 µM -0.740626015577859 0.222747493013651 no 2617 0.229460114744464 3646 22333232 SGTC_1329 1447-1697 50.6 µM -0.74129397813024 0.222535909753108 no 2618 0.229257606072003 3759 2840515 SGTC_2978 9011784 42.97 µM -0.741712535229172 0.222403386379194 no 2619 0.229130761658941 3785 2994934 SGTC_74 000s-0487 160.283 µM -0.741928602971855 0.222334992720908 no 2620 0.22906529738423 3683 677548 SGTC_2290 7904846 200 µM -0.742658293839594 0.222104106511598 no 2621 0.228844292975424 3808 2962154 SGTC_2330 7979373 200 µM -0.74555841263112 0.221187815216881 no 2622 0.227967106439551 3715 1863007 SGTC_1716 st033144 30.6155 µM -0.74670801690224 0.220825197624091 no 2623 0.227619914729693 3743 674617 SGTC_3267 9137951 49.47 µM -0.746791787931186 0.220798787192737 no 2624 0.22759462670404 3743 16643986 SGTC_510 ag-490 170 µM -0.747720753917864 0.220506034029662 no 2625 0.227314305077826 3869 5328779 SGTC_3030 9087619 49.47 µM -0.74835215301897 0.22030718274943 no 2626 0.22712388732758 3761 25236973 SGTC_442 cape 100 µM -0.748872368806298 0.220143424544128 no 2627 0.226967067899412 3711 5281787 SGTC_2386 9075165 157.42 µM -0.749039997138573 0.220090671866044 no 2628 0.22691654922769 3724 16452277 SGTC_2486 5283202 22.39 µM -0.750632718804622 0.219589803852321 no 2629 0.226436862274556 3790 1377751 SGTC_1959 st077091 55.8 µM -0.751589091385879 0.21928936529245 no 2630 0.226149102728814 3766 821356 YKL052C ASK1 SGTC_2098 5376439 882.5 nM -0.751631236077841 0.219276131233932 no 2631 0.226136426718037 3794 2844116 SGTC_93 0109-0045 59.227 µM -0.751842076275159 0.219209931177052 no 2632 0.226073017581928 3838 88733 SGTC_465 cgp-37157 41 µM -0.752181997165975 0.21910322628382 no 2633 0.225970809236782 3699 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_45 0kpi-0036 14.9 µM -0.755581320799802 0.218037785318851 no 2634 0.224950129349208 3746 2795021 SGTC_3165 9101544 49.47 µM -0.755635809155567 0.218020731535246 no 2635 0.224933789998731 3769 5002184 SGTC_1139 k015-0024 46.9 µM -0.756241071732058 0.217831347973909 no 2636 0.224752335963542 3741 2766652 SGTC_3074 9116018 49.47 µM -0.756548136640054 0.217735305226613 no 2637 0.224660311521288 3805 17027303 SGTC_2345 9052315 157.45 µM -0.757133005779708 0.217552439385027 no 2638 0.22448509091894 3796 6469265 SGTC_2714 st079313 56.9 µM -0.758164978071569 0.217229998046483 no 2639 0.224176112155712 3759 2939799 SGTC_726 3448-4391 34.2 µM -0.758921019544415 0.216993947015191 no 2640 0.223949902115507 3825 1356692 SGTC_1801 st050089 28.441 µM -0.762936756135493 0.21574264238234 no 2641 0.222750557099103 3797 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2588 indole-3-carbinol 100 µM -0.764603110514 0.215224636329638 no 2642 0.222253958190487 3801 3712 Induces cell cycle arrest. SGTC_1849 st056239 19.2 µM -0.767275168931418 0.21439550385037 no 2643 0.221458964356865 3796 5393181 SGTC_2685 mycophenolic acid 18.85 µM -0.768290773851823 0.214080852231948 no 2644 0.221157227350472 3772 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1078 idebenone 36.1 µM -0.769145647480343 0.213816206331761 no 2645 0.220903426154952 3847 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2558 carylophyllene oxide 100 µM -0.769868655430424 0.213592531276747 no 2646 0.220688904422957 3871 6708694 An oxygenated terpenoid and antifungal agent. SGTC_761 k216-0224 480 µM -0.770188934839273 0.21349349087363 no 2647 0.220593913336554 3800 1340404 SGTC_2394 5221648 200 µM -0.771563434754382 0.213068756545985 no 2648 0.220186518986842 3871 788586 SGTC_294 k038-0071 157 µM -0.772230433646111 0.212862824937878 no 2649 0.219988979715833 3801 24152826 SGTC_969 1313-0238 134 µM -0.773786411060751 0.21238287877898 no 2650 0.219528554886503 3799 5212874 SGTC_1277 0873-0036 22 µM -0.77387769573737 0.212354741381743 no 2651 0.219501560299049 3839 5965735 SGTC_3147 9097027 49.47 µM -0.774813073728336 0.212066547977805 no 2652 0.219225061416158 3820 25236841 SGTC_1228 0124-0032 52.5 µM -0.774959907726979 0.212021328660266 no 2653 0.219181675294286 3863 X1228 SGTC_1687 st020778 55.3625 µM -0.77594208245434 0.21171900103901 no 2654 0.218891591870306 3801 4259299 SGTC_1570 verbenone 133 µM -0.776263035276896 0.211620261826251 no 2655 0.218796846970345 3802 29025 A natural terpanoid with antifungal properties. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.776509173624039 0.211544557104948 no 2656 0.218724203207167 3824 4174840 SGTC_518 1021-0119 62.6 µM -0.776936159536051 0.211413266753091 no 2657 0.218598218133985 3796 1097762 SGTC_1382 3002-2117 298 µM -0.779032543826411 0.210769359634716 no 2658 0.217980272216138 3829 1497314 SGTC_3153 9100258 49.47 µM -0.783447255496059 0.209417143242679 no 2659 0.216682257721806 3744 25236848 SGTC_2041 5107442 45.335 µM -0.783447512800909 0.209417064579834 no 2660 0.216682182199495 3807 793005 SGTC_1331 1472-0049 76.2 µM -0.785886681306142 0.208672147286565 no 2661 0.215966938996722 3762 24051409 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.785940988717167 0.20865557970307 no 2662 0.21595102988691 3795 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2040 5100729 123 µM -0.786916607661313 0.208358079346676 no 2663 0.21566534242909 3822 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1055 3448-0672 86 µM -0.787041502667108 0.208320012562391 no 2664 0.215628785641328 3837 748378 SGTC_933 2914-0560 114 µM -0.787216368248817 0.208266722125946 no 2665 0.215577608495592 3849 463887 SGTC_533 1222-0222 6.71 µM -0.788916291839386 0.207749088219782 no 2666 0.215080466478874 3898 3982874 SGTC_2607 solasodine 47.35 µM -0.794665218214719 0.206004155788305 no 2667 0.213404134981636 3849 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2231 micatex 6.853 µM -0.795191324720417 0.205844905563406 no 2668 0.213251108703569 3852 20737 An antifungal of unknown mechanism. SGTC_2834 9001755 58.44 µM -0.795244137954947 0.205828923254638 no 2669 0.213235750685922 3778 2989575 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.795390467866492 0.205784644832379 no 2670 0.213193201513686 3799 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2229 7354935 190 µM -0.795789439928873 0.205663947354787 no 2671 0.213077215319042 3752 318112 SGTC_2255 7941087 197.44 µM -0.79636038928117 0.205491296222483 no 2672 0.212911297212473 3824 935561 SGTC_716 1683-5115 658 µM -0.797723851735898 0.205079342925466 no 2673 0.212515379642258 3820 723597 SGTC_491 tetrandrine 80.3 µM -0.798300143388463 0.204905371217216 no 2674 0.212348167426046 3815 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_831 k061-1017 217 µM -0.799139082214885 0.204652268133278 no 2675 0.212104885067631 3887 1240153 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.799434193849878 0.20456327886745 no 2676 0.212019344938784 3817 66535 A nucleotide analog. SGTC_1372 2752-0194 270 µM -0.800224822142834 0.204324982823568 no 2677 0.211790275364925 3792 823334 SGTC_1018 4259-0013 28.1 µM -0.800244535040252 0.204319043451914 no 2678 0.211784565777255 3923 6801262 SGTC_2413 inermin 26.06 µM -0.80206812903317 0.203770050774457 no 2679 0.211256774848383 3926 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_620 0109-0052 432 µM -0.803071921032154 0.203468234956811 no 2680 0.210966583004245 3809 493037 SGTC_976 1348-1067 47.6 µM -0.803308777965482 0.203397056748659 no 2681 0.210898142802334 3869 5310671 YGL099W LSG1 SGTC_2734 clemastine 41.6 µM -0.804030491231165 0.203180265303999 no 2682 0.210689682851722 3837 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3075 9116269 49.47 µM -0.804753336795271 0.202963272049288 no 2683 0.210481017062272 3844 17015205 YNL244C SUI1 SGTC_2870 9038528 12.99 µM -0.806147873273759 0.202545033085887 no 2684 0.210078795347722 3869 6463316 SGTC_1750 st081859 2.357 µM -0.807380571915378 0.202175760653433 no 2685 0.209723628294282 3819 5291695 SGTC_595 3909-8003 73.7 µM -0.80743756736554 0.202158696602789 no 2686 0.209707215220373 3931 699517 SGTC_413 propylparaben 100 µM -0.807755595864816 0.202063496850358 no 2687 0.209615645894507 3799 7175 A pharmaceutical preservative. SGTC_2534 helenine 20.12 µM -0.807819179766621 0.202044466643656 no 2688 0.209597341126792 3833 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2686 alizarin 95.37 µM -0.807882741074302 0.202025444271291 no 2689 0.209579043803242 3869 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_404 fumagillin 50 µM -0.809116756310933 0.201656345610424 no 2690 0.209223995418675 3828 12015870 A methionine aminopeptidase binder. SGTC_1407 3909-7909 12.3 µM -0.810547913466147 0.20122878731033 no 2691 0.208812669525559 3833 4411780 SGTC_1021 4476-0760 85.3 µM -0.810704314400966 0.201182095487634 no 2692 0.208767747558313 3877 746768 SGTC_1844 rapamycin 4 nM -0.810919640545449 0.201117822805285 no 2693 0.208705910226017 3788 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2347 9049783 174.81 µM -0.811783731850141 0.200860024155155 no 2694 0.208457869210717 3875 6467988 YPL169C MEX67 SGTC_2539 epi(13)torulosol 80 µM -0.811931484696996 0.200815962465643 no 2695 0.208415473550545 3880 6708597 SGTC_674 0498-0004 451 µM -0.812033515543821 0.200785539016792 no 2696 0.208386200161962 3860 4231473 SGTC_2273 7815444 169.05 µM -0.813663694451242 0.20029982928741 no 2697 0.207918819032047 3770 2824616 SGTC_2097 5376186 200 µM -0.814983545094126 0.199907099111066 no 2698 0.207540864530033 3793 742755 SGTC_860 0443-0016 25.1 µM -0.816642407192075 0.199414151162475 no 2699 0.207066406489393 3887 5337942 SGTC_1706 st031321 9.9705 µM -0.816775286385652 0.199374696424916 no 2700 0.207028428939502 3887 6103185 SGTC_1300 1094-0077 113 µM -0.816853996135851 0.199351327996052 no 2701 0.207005935235991 3805 5532636 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.817174510191402 0.199256186425136 no 2702 0.206914353537745 3891 115019 SGTC_1640 st009078 66.4 µM -0.817382605104108 0.199194430058703 no 2703 0.206854906628507 3821 690618 SGTC_222 nsc-310342 10.666 µM -0.817615716598457 0.199125263209443 no 2704 0.206788325186999 3801 432556 SGTC_5 0352-0601 109.883 µM -0.819633744440942 0.198527096229552 no 2705 0.206212465412503 3773 762456 SGTC_1374 2889-5571 141 µM -0.820098911272319 0.19838936923511 no 2706 0.206079861420294 3892 2853281 SGTC_2754 granisetron 64.02 µM -0.820167194944636 0.19836915660082 no 2707 0.206060400214568 3852 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2178 5812956 200 µM -0.820907478668117 0.198150105159411 no 2708 0.205849485422762 3843 5403383 SGTC_495 decylubiquinone 155 µM -0.824608663885417 0.19705710905416 no 2709 0.204796900512847 3902 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_38 0929-0051 58.268 µM -0.826332812318363 0.196549199417949 no 2710 0.204307662549795 3895 1379719 SGTC_1199 1638-0010 4.46 µM -0.826677870524586 0.196447645511056 no 2711 0.20420983374688 3847 3111136 SGTC_2035 5154463 94.595 µM -0.826723536697928 0.196434207905681 no 2712 0.20419688884188 3886 2769623 SGTC_2107 5363541 170.161 µM -0.827304476500347 0.196263310745497 no 2713 0.204032253575558 3851 244052 SGTC_381 3461-2219 42.7 µM -0.830506274229365 0.195323044829434 no 2714 0.203126300969173 3846 2883159 SGTC_1793 st048256 72.231 µM -0.830551267055465 0.195309851400272 no 2715 0.203113587328264 3751 672022 SGTC_2521 angolensin 13.4 µM -0.83062703279007 0.195287635529749 no 2716 0.203092179247873 3952 821428 A flavenoid. SGTC_789 1309-1135 70.6 µM -0.833241967875704 0.194521830971849 no 2717 0.202354138951682 3868 3092424 SGTC_1744 st037937 38.9 µM -0.833802356436965 0.194357954846189 no 2718 0.202196183622254 3955 1016152 SGTC_2374 9071832 200 µM -0.834195399049992 0.19424306637102 no 2719 0.202085441703613 3809 17381698 SGTC_314 1671-0008 2.74 µM -0.836769263973694 0.19349173446673 no 2720 0.201361138619036 3799 3913060 SGTC_1038 k292-0204 154 µM -0.837458516168437 0.193290837521172 no 2721 0.201167442823805 3839 4454212 SGTC_1929 genistein trimethyl ether 50.5 µM -0.837968140137826 0.193142378859719 no 2722 0.201024298583933 3829 136420 SGTC_455 paf C-16 10 µM -0.838386994505601 0.19302041444023 no 2723 0.200906695655593 3853 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1001 4048-4355 44.4 µM -0.839570567107919 0.192676029263829 no 2724 0.200574603826377 3870 21824233 SGTC_2497 7-hydroxyflavone 100 µM -0.839777212556217 0.192615939978302 no 2725 0.200516656185449 3905 5281894 SGTC_2186 6124449 200 µM -0.840165027646287 0.192503200297348 no 2726 0.200407931987923 3879 3834182 YLR033W RSC58 SGTC_837 0091-0265 12.5 µM -0.841799583654197 0.192028470609463 no 2727 0.199950072516236 3855 759367 SGTC_235 0330-0087 5 mM -0.842194380807598 0.191913915831693 no 2728 0.199839579302693 3908 46494818 YHR062C RPP1 SGTC_2289 7946404 165.07 µM -0.842665844518473 0.191777170218151 no 2729 0.199707677285813 3923 1246120 YPR165W RHO1 SGTC_1751 st044839 27.194 µM -0.842759233661098 0.191750090260785 no 2730 0.199681555900293 3837 5291326 SGTC_1063 disulfiram 1.84 µM -0.843252453585007 0.191607110608418 no 2731 0.199543634052366 3875 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_616 4092-0450 108 µM -0.843483534964008 0.191540144838292 no 2732 0.199479035201783 3920 787165 SGTC_1729 st035615 45.989 µM -0.84435572969506 0.191287518107934 no 2733 0.199235326419035 3947 17385451 SGTC_1669 st015249 58.4 µM -0.845328938951216 0.191005874246754 no 2734 0.198963603927851 3970 722793 SGTC_2087 5276107 200 µM -0.845708853278342 0.190895997229049 no 2735 0.198857591520726 3867 144405 SGTC_2383 9036125 200 µM -0.846317023344459 0.19072018591017 no 2736 0.198687956859421 3809 79580 SGTC_2447 5741742 33.78 µM -0.846559844971484 0.190650018196076 no 2737 0.198620251889828 3943 1776504 SGTC_700 3453-2283 142 µM -0.847297043112798 0.190437088516341 no 2738 0.198414787184236 3951 565664 SGTC_2782 7736369 71.43 µM -0.852925440819267 0.188816220307513 no 2739 0.196850326206742 3954 2950836 YOL077C BRX1 SGTC_2732 terfenadine 20 µM -0.853585278618312 0.188626758292748 no 2740 0.1966674090869 3907 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_815 1582-0027 36.9 µM -0.853630553024233 0.18861376275953 no 2741 0.196654862105485 3973 3128206 SGTC_1906 st060206 94.7 µM -0.854346108762755 0.188408443460174 no 2742 0.196456623194623 3930 5133468 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.855109238021148 0.188189625537707 no 2743 0.196245337929568 3936 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3305 9127027 53.8275 µM -0.855619895781795 0.188043288327708 no 2744 0.196104030648964 3835 41905295 SGTC_835 0312-0010 67.2 µM -0.856446896090301 0.187806447100692 no 2745 0.195875317192149 3875 1626196 SGTC_3252 9135871 49.47 µM -0.857929420534499 0.187382334401787 no 2746 0.195465718740991 3921 17682838 SGTC_185 k048-0037 25.491 µM -0.85855315189209 0.18720407773556 no 2747 0.195293547052332 3949 6827589 SGTC_601 0986-0029 62.9 µM -0.859161732418132 0.18703025214799 no 2748 0.195125646366512 3877 24747981 SGTC_2327 6189656 200 µM -0.861284731040972 0.186424653519269 no 2749 0.194540621573952 4001 5349088 SGTC_2136 5328288 199.296 µM -0.86138666689584 0.186395606272767 no 2750 0.194512558472015 3930 262395 SGTC_3293 9120939 62.045 µM -0.861506499144477 0.186361462924604 no 2751 0.194479571615468 3897 934087 SGTC_435 c-PAF 6.7 µM -0.862104120609916 0.186191242758429 no 2752 0.194315112036494 3934 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1812 st052057 4.327 µM -0.862104943627343 0.186191008405324 no 2753 0.194314885608559 3935 3645418 SGTC_875 0709-0210 25.7 µM -0.862340409476823 0.18612396732952 no 2754 0.194250111019368 3906 6251364 SGTC_2268 7933382 153.85 µM -0.862410412480621 0.186104039186135 no 2755 0.194230856343286 3933 935025 YOR257W CDC31 SGTC_2585 alliin 100 µM -0.862620652317604 0.186044196996703 no 2756 0.1941730358132 3969 87310 A garlic compound which reacts with lipids. SGTC_2420 aureobasidin a 50 nM -0.862742452233209 0.186009533603471 no 2757 0.194139542982777 4067 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3215 9129942 49.47 µM -0.86774464455233 0.18458940566187 no 2758 0.192767069895206 3898 17682944 SGTC_2265 7929201 200 µM -0.867980988474301 0.1845224745907 no 2759 0.192702370194685 3894 1265108 SGTC_1701 st028638 40.4 µM -0.868212094216885 0.184457041535938 no 2760 0.192639117291318 3882 3490878 SGTC_1002 4049-0206 172 µM -0.868442831239245 0.184391727277588 no 2761 0.19257597796549 3943 4662749 SGTC_943 3253-1379 105 µM -0.869030493498908 0.18422544391738 no 2762 0.192415226068561 3905 668464 SGTC_2905 7799065 20.05 µM -0.86942458197513 0.184113985975537 no 2763 0.192307471227991 3828 1296806 SGTC_1958 st076513 41.9 µM -0.869637013859171 0.184053922414653 no 2764 0.192249401705674 3908 732122 YGL099W LSG1 SGTC_2177 5811945 192 µM -0.869834154927275 0.183998193134862 no 2765 0.192195521615387 3975 5343475 SGTC_1122 capsaicin 818.572 nM -0.870735131698078 0.18374363218335 no 2766 0.191949395700504 4031 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1337 1486-1011 40.3 µM -0.873261937256693 0.183030882666412 no 2767 0.1912601610086 3916 X1337 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.873327835744212 0.183012317438862 no 2768 0.191242206253689 3991 5393153 SGTC_1979 st071809 45.3 µM -0.874704145619365 0.182624845598628 no 2769 0.190867451933433 4029 4976333 SGTC_641 4092-0595 30 µM -0.875358508703764 0.182440802895898 no 2770 0.190689434066162 3963 786260 SGTC_1945 st075991 56.6 µM -0.879838937885191 0.181183775669889 no 2771 0.189473283792446 3974 1084980 SGTC_685 1278-0033 54.9 µM -0.880730687573278 0.180934235604309 no 2772 0.189231801473234 3957 3590572 SGTC_2666 tannic acid 100 µM -0.881086320409283 0.180834778274143 no 2773 0.189135550372576 3956 16134267 A thiamine antagonist. SGTC_689 0833-0039 98 µM -0.882566812367584 0.18042110789177 no 2774 0.188735183176712 3915 5374726 SGTC_1430 4049-0248 69.1 µM -0.882735493007835 0.180374013838747 no 2775 0.188689600298765 3949 22774488 SGTC_937 3122-0005 46.7 µM -0.883206922473005 0.180242436056982 no 2776 0.188562241042542 4005 759535 SGTC_1341 1486-1360 280 µM -0.883554360502563 0.180145503330028 no 2777 0.188468412687424 3923 3976547 SGTC_138 0850-0259 40.9225 µM -0.884662446862341 0.179836573816187 no 2778 0.188169357710081 3927 6813004 SGTC_1924 st058459 75.1 µM -0.886058171332214 0.179447925952034 no 2779 0.187793090745558 3909 688683 SGTC_2784 7567673 72.73 µM -0.886390735457361 0.179355399424493 no 2780 0.187703504905359 3922 3471247 SGTC_375 3970-0961 9.27 µM -0.886763207899991 0.179251805160345 no 2781 0.187603199944117 3913 2898222 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.886831522265066 0.179232809245006 no 2782 0.18758480682284 3947 75037 A free radical scavenger. SGTC_2092 5303694 80.6725 µM -0.887104817737493 0.179156827678281 no 2783 0.18751123524906 3952 1963699 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.888077918043115 0.178886451016443 no 2784 0.187249419919523 4035 4213774 SGTC_1282 0886-0010 32.4 µM -0.889267005805739 0.178556410918502 no 2785 0.186929799600523 4016 2836211 YNL267W PIK1 SGTC_1703 st026983 48.3 µM -0.889308584224973 0.178544877464561 no 2786 0.186918629659425 3962 1104023 SGTC_376 3970-0862 59.1 µM -0.889802376049561 0.178407940235067 no 2787 0.186786005267871 3995 3135186 SGTC_1617 st002906 78 µM -0.891204844732372 0.178019371762792 no 2788 0.186409642902353 3946 5150859 SGTC_2586 curcumin 80 µM -0.892306776606001 0.177714444758473 no 2789 0.186114261499991 3939 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2368 9071271 200 µM -0.892425767687441 0.177681537226347 no 2790 0.186082382380652 3966 27209959 SGTC_2839 9003951 25.97 µM -0.893196298738152 0.177468536381517 no 2791 0.185876029927458 4013 2990634 SGTC_443 clozapine 122 µM -0.893573024237565 0.177364455402762 no 2792 0.185775192439294 3839 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2250 alverine citrate 130 µM -0.896579357196854 0.17653525310765 no 2793 0.184971708635905 3866 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1848 st056003 16.4 µM -0.9004697659384 0.175465852166779 no 2794 0.183935153984385 3996 146492 SGTC_2969 9091408 28.7 µM -0.902095350931385 0.175020228045299 no 2795 0.183503109158396 3931 4286311 SGTC_2641 levomentholum 100 µM -0.903503575573547 0.174634770222617 no 2796 0.18312934571722 3937 16666 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.907807239303913 0.173460119707848 no 2797 0.18199003646486 4046 688664 SGTC_3174 9107204 49.47 µM -0.908309539430215 0.173323349395478 no 2798 0.181857351949176 4032 3938802 SGTC_2125 5246583 200 µM -0.91054637777312 0.172715119052178 no 2799 0.18126721742467 3948 835267 SGTC_632 0781-2353 4.65 µM -0.910677818644488 0.172679420656997 no 2800 0.181232577345365 4049 6811515 YHR007C ERG11 SGTC_251 melphalan 456.522 µM -0.910868452690457 0.172627654180402 no 2801 0.181182344795779 4015 460612 A DNA alkylator. SGTC_2708 st078559 56 µM -0.911118022531935 0.172559898707263 no 2802 0.181116595699336 3937 17250902 SGTC_2526 patulin 37.61 µM -0.911368591868607 0.17249188894451 no 2803 0.181050598324949 4034 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2524 avocatin b 10.57 µM -0.912197133142147 0.172267127237666 no 2804 0.180832476416271 3935 6710748 SGTC_1247 0448-0043 5.84 µM -0.914387318247769 0.171673887296294 no 2805 0.180256681567899 4034 3089013 YGL099W LSG1 SGTC_2932 9016711 44.54 µM -0.91441756008264 0.171665705049758 no 2806 0.180248739117971 4018 7117328 SGTC_1059 3448-6867 171 µM -0.916410546081233 0.171127030975173 no 2807 0.179725803010796 3899 3934407 SGTC_931 2812-0076 566 µM -0.917070689812857 0.170948842670703 no 2808 0.17955279941658 3966 3450959 SGTC_2412 st077135 33.4 µM -0.917106836641072 0.170939089221443 no 2809 0.179543329455739 4088 13258915 SGTC_1821 st053465 65.6 µM -0.919122579768293 0.170395747567576 no 2810 0.179015730028359 3997 675086 SGTC_2673 kobusone 100 µM -0.919415544721737 0.170316871307454 no 2811 0.178939130826975 4047 6710676 An epoxy ketone and protein crosslinker. SGTC_1356 1502-0781 85.8 µM -0.92138338828977 0.169787666336659 no 2812 0.17842514924102 3964 567702 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.921591060699951 0.169731879333411 no 2813 0.178370961537999 3998 364106 SGTC_228 caffeine 993.056 µM -0.922182478721921 0.169573071232804 no 2814 0.178216700389317 3988 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1527 coumarin 137 µM -0.925034119614356 0.168808684537763 no 2815 0.177474079901124 4109 323 A hepatotoxic, DNA x-linker. SGTC_1103 duloxetine 36.1 µM -0.92666675009853 0.168372053656115 no 2816 0.177049793066155 4085 60835 A selective serotonin reuptake inhibitor. SGTC_2430 5571206 200 µM -0.926988340053607 0.16828613330212 no 2817 0.176966294110919 4028 1731771 SGTC_1972 st070201 17.4 µM -0.927333461524395 0.168193957327083 no 2818 0.176876713021472 3986 2829099 SGTC_1892 st058411 7.36 µM -0.927539838672304 0.168138853082817 no 2819 0.176823158651096 4019 3934738 SGTC_624 k048-0052 28 µM -0.929918244503452 0.167504639384607 no 2820 0.176206707957511 3985 6835531 SGTC_3264 9137442 49.47 µM -0.930764595492492 0.167279327977452 no 2821 0.175987673723315 4006 17015726 SGTC_2004 4023728 41.89 µM -0.932108771535024 0.166921889702492 no 2822 0.175640157689067 4011 360084 YDR527W RBA50 SGTC_4 0960-0234 25.671 µM -0.933381788218987 0.166583828403592 no 2823 0.175311440003456 4012 6821112 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.934587821413795 0.166263963121985 no 2824 0.175000378842188 4046 368090 SGTC_2241 6772625 37.8075 µM -0.934844967740521 0.166195813865895 no 2825 0.174934100751535 3887 2285411 SGTC_3269 9137823 49.47 µM -0.935159144198515 0.166112574903012 no 2826 0.174853145071882 3909 17682936 SGTC_2818 7996756 12.99 µM -0.935956539177712 0.165901431359482 no 2827 0.174647782437545 4016 2241621 SGTC_2001 4023502 57.655 µM -0.938280458785763 0.165287066725903 no 2828 0.174050149693957 4048 108941 YCR052W RSC6 SGTC_1531 st059297 52.4 µM -0.942103664687801 0.164279549930893 no 2829 0.173069784224019 4031 7566702 SGTC_524 r073-0010 27.8 µM -0.942113026880378 0.164277087641198 no 2830 0.173067387849658 3937 2772106 SGTC_3209 9113616 49.47 µM -0.942473634703407 0.164182264723636 no 2831 0.172975101696475 4081 16649353 SGTC_403 arphamenine a 50 µM -0.944272479883637 0.163709783251666 no 2832 0.172515212648288 3989 5487158 An arginine aminopeptidase inhibitor. SGTC_2723 salbutamol 83.58 µM -0.944312212558776 0.163699357111181 no 2833 0.172505063484164 4046 9884233 β2-adrenoceptor agonist SGTC_2283 7944793 200 µM -0.945472143730895 0.163395172790713 no 2834 0.172208942886886 4063 2970533 SGTC_2014 4013930 200 µM -0.949884770700713 0.162241347841953 no 2835 0.171085402957868 3960 64556 SGTC_184 1494-0393 24.714 µM -0.950390488761307 0.162109451033407 no 2836 0.170956937503635 4004 3090647 SGTC_1111 tnp00062 510.699 nM -0.951161835880137 0.161908409775438 no 2837 0.170761114286229 4076 676306 SGTC_3338 9144300 39.5675 µM -0.951301111602677 0.161872126750106 no 2838 0.170725771426214 4045 4901274 SGTC_176 1486-1328 72.834 µM -0.954259616577443 0.16110265168984 no 2839 0.169976122074841 4112 22310231 SGTC_1085 doxorubicin 7.67 µM -0.955797031633849 0.160703730690161 no 2840 0.169587394157154 4054 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_710 3448-4187 58 µM -0.955943964468122 0.160665639071453 no 2841 0.169550272786401 4017 3946412 SGTC_2776 terbinafine 19.92 µM -0.957250651231466 0.160327146335929 no 2842 0.169220378492984 4065 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1705 st027868 56.3335 µM -0.958333718056067 0.160046935081861 no 2843 0.168947253244234 3984 292948 SGTC_945 3381-0768 11.3 µM -0.958659324544455 0.15996275675524 no 2844 0.168865197958432 4089 1126236 YIL048W NEO1 SGTC_1473 k844-0725 134 µM -0.960452396342518 0.159499716728991 no 2845 0.168413789208644 4096 54682906 SGTC_1296 1068-0102 11.9 µM -0.966692204982437 0.157895204515485 no 2846 0.166848962518586 4060 767053 SGTC_2038 4100038 30.985 µM -0.96703921864973 0.157806285180445 no 2847 0.166762214204861 4051 3596803 SGTC_693 4161-2696 114 µM -0.967550545098634 0.15767532202186 no 2848 0.166634443153472 4082 805759 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.967633423792919 0.15765410149578 no 2849 0.166613739247709 4040 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2505 galangin 7.89 µM -0.967722752762946 0.157631231521533 no 2850 0.166591425859349 3941 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3255 9139072 49.47 µM -0.967926543861693 0.157579065148624 no 2851 0.166540528317169 4061 17646060 SGTC_1410 3909-8106 77.9 µM -0.968125452522816 0.15752815952069 no 2852 0.166490859861832 4105 1039210 SGTC_2436 5633522 8.09 µM -0.96860849879401 0.157404581068888 no 2853 0.166370280683944 4047 5724242 SGTC_1597 7-benzyloxygramine 47.5 µM -0.969258599056416 0.157238365558058 no 2854 0.166208090121476 3995 260807 SGTC_1323 1348-1351 11.2 µM -0.969460305333538 0.157186817422818 no 2855 0.166157788105343 3997 6989654 SGTC_2113 5491891 107.031 µM -0.969779182783724 0.157105347649305 no 2856 0.166078285713858 4070 789979 SGTC_803 4488-1585 147 µM -0.970608211661101 0.156893669624995 no 2857 0.165871707613975 4051 747204 SGTC_2907 7721985 69.9 µM -0.971501553386518 0.156665780587565 no 2858 0.165649289979401 4098 3267881 SGTC_92 0063-0024 660.874 µM -0.972287074347969 0.156465576446992 no 2859 0.165453876185643 4123 3594437 SGTC_3082 9117008 49.47 µM -0.975411786155893 0.155670856143074 no 2860 0.164678019805555 4126 41448529 SGTC_337 1315-0038 354 µM -0.975960671682741 0.155531531289679 no 2861 0.164541977002414 4012 1626437 SGTC_3212 9128307 49.47 µM -0.97668049506197 0.155348941609865 no 2862 0.164363677202922 4020 27243542 SGTC_3224 9130643 49.47 µM -0.977530862895314 0.155133420493698 no 2863 0.164153203080338 4114 17644395 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.977680270285646 0.155095574398841 no 2864 0.164116241393582 4101 23665772 A membrane-active detergent. SGTC_613 3914-0030 117 µM -0.978186734632592 0.154967328262418 no 2865 0.163990988050749 3784 1145395 SGTC_2020 4017018 200 µM -0.978234244061514 0.154955301590596 no 2866 0.163979241709829 4145 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_374 0880-0231 82.3 µM -0.978268549772371 0.154946617728746 no 2867 0.163970760226065 3984 6833587 SGTC_3112 9123419 49.47 µM -0.979071152999117 0.154743545156913 no 2868 0.163772411920386 4101 17015854 SGTC_1373 2887-0003 58.5 µM -0.980338390145988 0.154423270288049 no 2869 0.163459555276412 4042 776948 SGTC_2301 7769476 200 µM -0.98582750910922 0.153041042763232 no 2870 0.162108882063869 4104 977820 SGTC_2742 clothiapine 36.27 µM -0.987186060778761 0.152700212805985 no 2871 0.161775716981908 4045 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_538 2922-0838 53.3 µM -0.991864561957932 0.151530337586998 no 2872 0.160631799139109 4075 777039 SGTC_3051 9093778 49.47 µM -0.992119607560027 0.151466734287687 no 2873 0.160569591383541 4120 17217378 SGTC_2703 st077852 53.4 µM -0.997054578801034 0.150239545429437 no 2874 0.159369009240707 4135 6281836 SGTC_1796 st049173 110.4 µM -0.997071703076292 0.15023529867232 no 2875 0.15936485349836 4034 94134 SGTC_61 0978-8327 98.565 µM -0.997538439790844 0.150119580495503 no 2876 0.159251612521997 4005 6150059 YHR072W ERG7 SGTC_1442 4112-3290 3 µM -1.00189635772929 0.149041988383738 no 2877 0.158196825961742 4064 704353 SGTC_655 k060-0012 42 µM -1.00284397013766 0.148808355789771 no 2878 0.157968074965129 4070 5994525 SGTC_871 0574-0004 149 µM -1.00304286625695 0.148759349306967 no 2879 0.157920089584632 4064 9551173 SGTC_2998 9066762 71.4286 µM -1.003732536553 0.148589503376813 no 2880 0.157753774900914 4157 4945196 SGTC_736 0958-0254 92.6 µM -1.00419579818879 0.148475488200787 no 2881 0.157642123511258 4195 6812352 SGTC_913 3487-1245 167 µM -1.00522781647089 0.148221704434314 no 2882 0.157393581915117 4028 4016153 SGTC_2375 9072683 200 µM -1.00580799189802 0.148079160923226 no 2883 0.157253971072359 4155 16798029 SGTC_3048 9093155 49.47 µM -1.00609861218513 0.148007792817544 no 2884 0.157184068111719 4065 25236002 SGTC_1650 st011916 45.8 µM -1.01295009389413 0.146331932005704 no 2885 0.155541999605598 4019 242528 SGTC_2418 pentamidine 31.67 µM -1.01362453795674 0.146167655700434 no 2886 0.155380972192921 4062 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1483 3453-0561 55.9 µM -1.01574386347254 0.14565225184481 no 2887 0.154875687194772 4100 4546991 SGTC_206 4546-0025 72.014 µM -1.01589676145041 0.145615115532437 no 2888 0.154839275613133 4158 6620745 YIL048W NEO1 SGTC_2303 7774051 200 µM -1.01708496695574 0.145326737655683 no 2889 0.154556505541553 4157 2953184 SGTC_3055 9094636 49.47 µM -1.01733559863916 0.145265958363377 no 2890 0.154496903635646 4134 25236176 SGTC_16 erodoxin 22.806 µM -1.0175421519078 0.14521588113888 no 2891 0.154447795295879 4136 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_801 0866-0028 10.1 µM -1.01932912548604 0.144783128350321 no 2892 0.154023370586832 4121 6849771 SGTC_350 k064-0020 19.8 µM -1.01951821632739 0.144737386938148 no 2893 0.153978504747071 4137 2790705 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.01981911855601 0.144664618220489 no 2894 0.15390712709948 4109 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_922 1866-0035 480 µM -1.02192198778397 0.144156758611874 no 2895 0.153408912393008 4051 3156169 SGTC_1040 k898-0338 155 µM -1.02412221490996 0.143626674615686 no 2896 0.152888776432783 4129 20969351 SGTC_2787 5284540 71.43 µM -1.02437908539628 0.143564874628959 no 2897 0.152828128303931 4167 736958 SGTC_648 0375-0473 33.3 µM -1.02465697634439 0.143498037583802 no 2898 0.15276253513011 4086 1713139 SGTC_1235 benzylparaben 21.5 µM -1.02475882088229 0.143473547667441 no 2899 0.152738500496902 4129 7180 SGTC_2942 9052777 62.25 µM -1.02723504946282 0.142878972804232 no 2900 0.152154898888427 4175 6469503 SGTC_3311 9131146 2.8755 µM -1.02756655702898 0.142799500081519 no 2901 0.152076881175074 4095 4900406 YPR165W RHO1 SGTC_1312 1218-2183 165 µM -1.02784783085144 0.142732093392977 no 2902 0.152010706417762 4154 6744073 SGTC_397 arbidol 50 µM -1.02920793684994 0.142406450332742 no 2903 0.151690986746966 4166 131410 A RNA synthesis inhibitor. SGTC_2080 5212524 12.4 µM -1.03130417475791 0.141905543958403 no 2904 0.151199100614075 4013 260183 SGTC_1830 st055982 50.3 µM -1.03147961361889 0.141863676144643 no 2905 0.151157981730972 4074 455313 An antimicrobial agent. SGTC_2077 5212015 200 µM -1.03216720943501 0.14169966467156 no 2906 0.150996896617481 3966 780900 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.03409726219472 0.14123997776945 no 2907 0.150545348027049 4097 442882 SGTC_1314 1222-0010 41.1 µM -1.03456018904542 0.141129871478992 no 2908 0.150437177107684 4126 3526027 SGTC_3093 9117344 49.47 µM -1.03573076444672 0.140851712017254 no 2909 0.150163882846429 4161 24824913 SGTC_105 0111-0055 734.78 µM -1.03715391536306 0.140514035273426 no 2910 0.149832065797825 4136 5179370 SGTC_1511 0906-3109 28.5 µM -1.03717953019939 0.140507962577192 no 2911 0.149826098013111 4140 2882180 SGTC_1713 st033146 12.748 µM -1.03800792234096 0.140311665656179 no 2912 0.149633183386514 4135 674619 SGTC_2479 5617353 43.85 µM -1.04007350265597 0.139823014426137 no 2913 0.149152876536765 4177 2731746 SGTC_1389 3405-0187 19 µM -1.04124865633118 0.139545526954412 no 2914 0.148880079534862 4089 799890 SGTC_1754 st042065 16.137 µM -1.04594476601584 0.138440381219089 no 2915 0.147793267208742 3947 1126236 YIL048W NEO1 SGTC_1623 st003709 20.3 µM -1.04609403860656 0.138405350660136 no 2916 0.147758808654544 4102 16192618 SGTC_1877 wortmannin 25 µM -1.04679023456307 0.138242050606528 no 2917 0.147598167654232 4136 312145 A covalent inhibitor of PI 3-kinase. SGTC_714 4296-0578 26.1 µM -1.04764747536487 0.138041156310075 no 2918 0.147400527758571 4173 1589775 SGTC_327 1273-0057 3.96 µM -1.05213325909649 0.13699316104312 no 2919 0.146369207396476 4012 3108138 SGTC_430 0958-0115 16.4 µM -1.05278123215298 0.136842228343834 no 2920 0.146220634242287 4103 6833180 SGTC_904 1141-0088 396 µM -1.0544968003771 0.136443169149173 no 2921 0.145827762374419 4145 1378119 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.05467450787254 0.136401878064397 no 2922 0.145787107248353 4167 7104 SGTC_998 3996-0085 177 µM -1.05638832235153 0.136004104789261 no 2923 0.145395419465041 4181 715391 SGTC_2427 5545055 42.75 µM -1.05719754029874 0.13581656302365 no 2924 0.145210721087269 4112 5372858 SGTC_654 1124-0271 80.9 µM -1.06344094508636 0.134375566235523 no 2925 0.143791016386126 4132 5403748 SGTC_35 0133-0054 64.071 µM -1.06358087005865 0.134343391857729 no 2926 0.143759306131817 4174 99677 SGTC_3135 9127742 49.47 µM -1.06380015841028 0.134292979290113 no 2927 0.143709619781698 4249 3643468 SGTC_800 3448-7362 155 µM -1.06966844912329 0.132948732367954 no 2928 0.142384286410859 4232 15991913 SGTC_174 3553-0389 74.3 µM -1.07001863811429 0.132868808660263 no 2929 0.142305459704969 4243 738071 SGTC_1567 st069303 68.4 µM -1.07084728614184 0.132679817930036 no 2930 0.142119050627859 4224 5581319 SGTC_1036 k216-0215 33.5 µM -1.07111155230551 0.132619585395511 no 2931 0.142059637227275 4140 622330 SGTC_2576 guaiol 23.12 µM -1.07121837902105 0.132595242397183 no 2932 0.142035624780398 4077 227829 SGTC_1332 1480-0653 17.5 µM -1.07173941812759 0.132476555413699 no 2933 0.141918545296594 4158 5749438 SGTC_551 k048-0028 34.9 µM -1.07302696863759 0.132183579579808 no 2934 0.141629508072396 4159 6836383 SGTC_1775 st081588 35.1725 µM -1.07529531491536 0.131668515835 no 2935 0.141121266559592 4167 1426443 YGL099W LSG1 SGTC_1482 3346-2049 8.48 µM -1.07787927210625 0.131083477110795 no 2936 0.14054381837857 4172 3826804 SGTC_3167 9103034 49.47 µM -1.08406983763669 0.129689171931665 no 2937 0.139166917565203 4250 5127859 SGTC_225 nsc-122657 1.016 µM -1.08447693007319 0.129597843538099 no 2938 0.139076695198978 4185 275685 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.08452912768197 0.129586136586078 no 2939 0.139065129719642 4229 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2200 6600604 21.907 µM -1.08551887051325 0.129364294323136 no 2940 0.13884595524999 4188 2904777 SGTC_1205 4161-2785 76 µM -1.08654616410926 0.129134313882014 no 2941 0.138618714232165 4243 3498106 SGTC_694 1315-0438 43.2 µM -1.08817954392051 0.128769232713432 no 2942 0.138257926729474 4172 6793154 SGTC_1874 staurosporine 7.6 µM -1.08919559822397 0.128542493233497 no 2943 0.138033819814707 4203 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1220 1838-0075 193 µM -1.08922758920158 0.128535358730032 no 2944 0.138026767721848 4082 5529645 SGTC_2034 5197015 53.07 µM -1.09082495753984 0.128179469279246 no 2945 0.137674956189068 4186 780676 SGTC_429 1112-0049 25.5 µM -1.09268283958506 0.127766399641829 no 2946 0.137266538401576 4152 2836170 SGTC_2983 9022671 12.99 µM -1.09541845634716 0.127159865661809 no 2947 0.136666675990139 4190 6405161 SGTC_2216 7189485 200 µM -1.09795812597271 0.126598572519908 no 2948 0.136111387267103 4197 731273 SGTC_227 fluconazole 33.516 µM -1.09934633609171 0.126292494270807 no 2949 0.135808514249693 4190 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2779 methotrexate 400 µM -1.10169627029436 0.125775547273375 no 2950 0.135296869490839 4214 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3106 9121286 49.47 µM -1.10387778530025 0.125296972509347 no 2951 0.134823078267983 4177 15943471 SGTC_1079 idarubicin 2.36 µM -1.10571859499291 0.124894130898674 no 2952 0.134424169483021 4205 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3161 9100388 49.47 µM -1.107341347962 0.124539759873496 no 2953 0.134073186917238 4272 25236368 SGTC_1715 st032160 10.2275 µM -1.11099470925474 0.123744526191939 no 2954 0.133285313324306 4141 5289825 SGTC_2649 anisomycin 9.56 µM -1.11409785921154 0.123071855798002 no 2955 0.132618603480433 4229 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_17 0960-0276 49.807 µM -1.11511596645393 0.122851719955221 no 2956 0.132400365148814 4197 6821114 SGTC_1463 k081-0032 34.1 µM -1.1204251035671 0.121708249211129 no 2957 0.131266326150151 3833 977755 SGTC_606 k015-0008 38.6 µM -1.12187847530914 0.121396533130294 no 2958 0.130957056887608 4303 1970475 SGTC_2232 chlorophetanol 41.5365 µM -1.12266098408979 0.121228934971002 no 2959 0.130790752138388 4281 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_520 3584-0023 682 µM -1.12332803417237 0.121086194359098 no 2960 0.130649100857721 4219 1340790 SGTC_3027 9089541 49.47 µM -1.12464812630444 0.120804059297475 no 2961 0.13036908571193 4224 9943819 SGTC_1499 4480-0877 67.3 µM -1.12465059279217 0.120803532583847 no 2962 0.130368562914625 4178 2861909 SGTC_1659 st012954 42.1 µM -1.12663075942196 0.120381193307521 no 2963 0.129949314205713 4164 24207262 SGTC_2489 cantharidin 73.42 µM -1.1278977928658 0.120111500688749 no 2964 0.129681543058653 4176 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2434 5670830 169.91 µM -1.13323166630097 0.118980836531131 no 2965 0.128558489698664 4258 1549830 SGTC_2569 tetrandrine 100 µM -1.13344011199432 0.118936803728539 no 2966 0.128514738680176 4235 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_897 1000-0139 31.4 µM -1.1393266869993 0.117698051601212 no 2967 0.127283460737914 4191 6151020 SGTC_13 0199-0087 65 µM -1.14166903094722 0.117207684726741 no 2968 0.126795809123249 4317 4589825 SGTC_55 0767-0285 6.563 µM -1.14377074102122 0.116768927659766 no 2969 0.126359363511178 4153 3116166 SGTC_357 1325-0123 420 µM -1.14486236540695 0.116541498051795 no 2970 0.126133087979545 4246 1098503 SGTC_956 1185-0240 191 µM -1.14649696854942 0.116201531673012 no 2971 0.125794790414047 4216 1416193 SGTC_309 k408-0051 1.48 µM -1.14667368595774 0.116164820011108 no 2972 0.125758254913546 4153 3640463 SGTC_346 4513-0042 7.16 µM -1.15334805539429 0.114784293771447 no 2973 0.12438377653581 4214 2827372 SGTC_1104 tacrolimus 29.8 µM -1.15337091709252 0.114779585204702 no 2974 0.124379086663489 4300 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1390 3413-2614 145 µM -1.15357693711637 0.114737159777382 no 2975 0.12433682908187 4262 3421432 SGTC_2155 5570423 76 µM -1.15427530816732 0.114593428182741 no 2976 0.124193658145098 4215 797402 SGTC_330 1488-0319 80.1 µM -1.15473171872096 0.114499563691027 no 2977 0.124100153133974 4269 6846614 SGTC_2774 tamoxifen 10.92 µM -1.1590293968583 0.113618394883203 no 2978 0.123222101322669 4228 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2286 7945697 125 µM -1.15904625001994 0.113614948960343 no 2979 0.123218666671383 4263 1245733 SGTC_2504 purpurogallin 52.29 µM -1.16040977368264 0.113336399597027 no 2980 0.122941004678974 4139 5281571 An antioxidant. SGTC_2728 chlorpromazine 9.18 µM -1.16178421545981 0.113056113138782 no 2981 0.122661563637854 4338 2726 A thorazine and dopamine antagonist. SGTC_1951 sophoraflavanone G 9.2 µM -1.1635215856995 0.112702523900448 no 2982 0.122308972717216 4220 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_446 go6976 132 µM -1.16374312672389 0.112657492747594 no 2983 0.12226406322765 4277 3501 A protein kinase C inhibitor. SGTC_2371 9071574 200 µM -1.1645076045823 0.112502201154064 no 2984 0.122109181681754 4254 45596039 SGTC_263 alizarin 107.927 µM -1.16702980928535 0.111990939774414 no 2985 0.121599165781038 4288 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1067 clotrimazole 1.36 µM -1.16745278261817 0.111905364231634 no 2986 0.121513782997541 4289 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3194 9111903 49.47 µM -1.17079222647976 0.111231372943526 no 2987 0.120841151595651 4297 17087251 SGTC_283 0987-0079 11.7 µM -1.17091854871754 0.111205934826228 no 2988 0.120815759285386 4254 411556 SGTC_511 blebbistatin 171 µM -1.17344718252633 0.11069760761077 no 2989 0.120308262858357 4314 3476986 A myosin inhibitor. SGTC_1383 3049-0032 20.7 µM -1.1741089326767 0.110564852374108 no 2990 0.120175697992699 4324 712864 SGTC_1689 st020265 53.493 µM -1.17527275148083 0.110331652890018 no 2991 0.119942806150174 4277 5758320 YPR016C TIF6 SGTC_109 0132-0036 33.701 µM -1.17576402409692 0.110233320378506 no 2992 0.119844593116673 4072 67274 A color developer. SGTC_711 k292-0785 179 µM -1.17689970297886 0.110006244956652 no 2993 0.119617770328037 4182 4146315 SGTC_164 4100-3994 89.624 µM -1.17811278593565 0.109764063760952 no 2994 0.119375822695321 4259 4615967 SGTC_3233 9132340 49.47 µM -1.17953068575847 0.109481478086903 no 2995 0.11909346259304 4267 17682950 SGTC_2254 7938975 95.19 µM -1.18080967170404 0.109227026314569 no 2996 0.118839170524872 4341 2969277 SGTC_3130 9127414 49.47 µM -1.18257012222832 0.108877483446628 no 2997 0.118489779731803 4274 1494646 SGTC_1045 1348-1485 165 µM -1.18502972069986 0.10839047036025 no 2998 0.118002848047991 4254 6810614 SGTC_1152 3909-8331 15.9 µM -1.18538853226311 0.10831955505509 no 2999 0.117931931876983 4233 16001939 SGTC_676 falcarinol 140 µM -1.18671910169723 0.108056873590624 no 3000 0.117669218939408 4305 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2084 5306078 60.6385 µM -1.18682827915525 0.108035340118214 no 3001 0.117647680909953 4202 679340 SGTC_3023 9089636 49.47 µM -1.18788478256215 0.107827121656104 no 3002 0.117439402898262 4347 17249241 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.18868076523046 0.107670438336778 no 3003 0.117282656231528 4151 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1399 3562-5772 25 µM -1.19037695770166 0.107337102707096 no 3004 0.11694913272217 4258 23847490 SGTC_1477 0139-0234 16 µM -1.19569098282091 0.106297608612641 no 3005 0.115908585747464 4283 620880 SGTC_973 1325-0077 65.9 µM -1.1977842742259 0.105890135397933 no 3006 0.1155005054302 4291 2835149 SGTC_3120 9124077 49.47 µM -1.19871298240089 0.105709718096602 no 3007 0.115319784113824 4414 18774327 YGL155W CDC43 SGTC_1568 digitonin 820 nM -1.20237763698895 0.104999965576047 no 3008 0.114608624741382 4276 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2351 9026858 72.31 µM -1.20328346871 0.104825061412993 no 3009 0.114433322011738 4185 1409300 SGTC_1004 4084-0029 199 µM -1.20481264432467 0.104530276601772 no 3010 0.114137818800287 4303 716894 YLR208W SEC13 SGTC_1310 1188-0297 994 nM -1.20663077443319 0.104180571051609 no 3011 0.113787184798994 4163 1588352 SGTC_2088 5278280 127.392 µM -1.20694948749157 0.10411935612624 no 3012 0.113725798820051 4339 791502 SGTC_1522 st012842 45.6 µM -1.20709435102847 0.104091540940965 no 3013 0.113697905069062 4135 3491067 YOR116C RPO31 SGTC_322 k048-0136 19.3 µM -1.20911063842697 0.10370495367034 no 3014 0.113310171314864 4350 6823282 SGTC_2101 5377231 179.231 µM -1.20962878871164 0.103605776015622 no 3015 0.113210683094889 4328 2844213 SGTC_2304 7443016 91.4 µM -1.21059796853941 0.103420452893401 no 3016 0.113024761608974 4225 939854 SGTC_1978 st071761 42 µM -1.21596640224867 0.102398276851113 no 3017 0.111998860461436 4326 5147680 SGTC_161 4065-0411 162.148 µM -1.21692449284764 0.102216626943743 no 3018 0.111816472866309 4288 1906281 YLR208W SEC13 SGTC_2852 9023854 51.95 µM -1.21966489233002 0.101698353125832 no 3019 0.111295967798429 4335 19798528 SGTC_2882 9058044 58.44 µM -1.22283995706921 0.101100269544341 no 3020 0.110695075188921 4335 18076804 SGTC_1728 st035614 33.7865 µM -1.22445508933199 0.100797014332217 no 3021 0.110390299207652 4249 15945546 SGTC_2846 9008642 19.48 µM -1.22626956951672 0.100457121595192 no 3022 0.110048624402532 4336 2992898 SGTC_2977 9011197 71.43 µM -1.22705641035222 0.100309988940881 no 3023 0.109900694812093 4375 2704722 SGTC_1246 0422-0085 105 µM -1.22760691241545 0.100207143212002 no 3024 0.109797282846814 4336 264295 SGTC_3260 9137109 49.47 µM -1.23281777237045 0.0992374520165348 no 3025 0.108821879549593 4251 17478346 SGTC_2910 7948405 25.97 µM -1.23378278967201 0.0990586270704893 no 3026 0.108641927085853 4243 2971328 SGTC_772 k072-0172 35.3 µM -1.23631405477422 0.0985906848402939 no 3027 0.108170924397585 4371 5861980 SGTC_2805 7950783 58.44 µM -1.24127332270646 0.0976785846525651 no 3028 0.107252398107098 4332 1178958 YDL195W SEC31 SGTC_659 k018-0002 107 µM -1.24214926945381 0.0975181269840933 no 3029 0.107090746521801 4283 6797879 YHR007C ERG11 SGTC_1101 ebselen 5.29 µM -1.24252655373674 0.0974490748936372 no 3030 0.107021174764704 4339 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_84 0443-0269 128.823 µM -1.24321614274362 0.0973229562291564 no 3031 0.106894097833399 4244 6150058 SGTC_773 4358-1457 44.6 µM -1.25285381978142 0.0955728405722982 no 3032 0.105129455411668 4333 1186886 SGTC_3223 9129970 49.47 µM -1.25329335525818 0.0954935806952232 no 3033 0.105049482881876 4333 17248386 SGTC_639 0833-0042 114 µM -1.25381133364984 0.0954002375973845 no 3034 0.104955294366237 4340 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_786 4544-0069 423 µM -1.25650489915179 0.0949159220316142 no 3035 0.104466485399287 4318 748821 YLR208W SEC13 SGTC_2081 5214970 32.255 µM -1.25852862433674 0.0945532403551723 no 3036 0.104100320928584 4286 2063512 SGTC_958 1222-0007 33 µM -1.25903058090971 0.0944634406018269 no 3037 0.104009643176402 4403 7312461 SGTC_3330 9141424 71.43 µM -1.2608856269289 0.0941321194995217 no 3038 0.10367502867667 4370 27261020 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.26557626534165 0.0932981725145416 no 3039 0.102832413993337 4339 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1805 st050013 60.3 µM -1.26590339687986 0.0932402161805407 no 3040 0.102773835058571 4291 4037144 SGTC_2869 9037858 32.47 µM -1.26636291946609 0.0931588496913839 no 3041 0.102691590027153 4305 27187042 SGTC_1860 st056228 74.6 µM -1.26762718715561 0.0929352598404562 no 3042 0.102465559151808 4308 688679 SGTC_1204 4049-0315 18.3 µM -1.2677120751374 0.0929202613504607 no 3043 0.102450395505906 4382 588402 SGTC_911 3456-4043 236 µM -1.27244078305014 0.0920875902705389 no 3044 0.101608275738453 4345 914281 SGTC_51 1013-0126 23.419 µM -1.27265039648757 0.0920508080430706 no 3045 0.10157106339985 4358 1627850 SGTC_2195 6536160 144.242 µM -1.27677430736845 0.0913293694291061 no 3046 0.100840969354895 4322 3834386 SGTC_367 0335-0881 7.1 µM -1.27780595532956 0.0911495497514231 no 3047 0.100658927029007 4291 23828853 SGTC_1024 4507-0395 26 µM -1.28317687353953 0.0902176208154198 no 3048 0.0997150581415276 4408 4201836 SGTC_1174 0739-0097 51.1 µM -1.28479143082169 0.0899388610069652 no 3049 0.0994325888180867 4392 728447 SGTC_1602 st001878 87.6 µM -1.28501297950758 0.0899006597328207 no 3050 0.0993938742101108 4331 595405 YLR310C CDC25 SGTC_723 4182-0001 115 µM -1.28619420531515 0.0896971864458479 no 3051 0.0991876464469196 4371 744821 YLR208W SEC13 SGTC_189 3970-0742 2.116 µM -1.28978299620316 0.0890810959763499 no 3052 0.0985630066695887 4335 2891807 SGTC_2855 9016525 58.44 µM -1.29231790753695 0.0886478275370434 no 3053 0.0981235364525402 4305 43811474 SGTC_2546 rhodinyl acetate 100 µM -1.29912602446258 0.0874919514613129 no 3054 0.0969503416391587 4310 6708682 SGTC_2060 5238662 140 µM -1.30152961150381 0.0870865706549145 no 3055 0.0965386177647028 4333 790130 SGTC_553 k007-0256 45.7 µM -1.30464180621438 0.086563764681391 no 3056 0.0960074228540899 4425 6287000 SGTC_1048 3161-0300 24.5 µM -1.30469780564673 0.0865543790805191 no 3057 0.095997884495933 4365 2165101 SGTC_2511 berberine 10.47 µM -1.30521587059216 0.0864675865764225 no 3058 0.0959096757682312 4349 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_52 0329-0193 875 nM -1.30694885486244 0.0861777289700269 no 3059 0.0956150410932226 4420 3739292 SGTC_1702 st027038 51 µM -1.30723167128063 0.0861304943822845 no 3060 0.0955670211225811 4398 5521182 SGTC_1014 4130-3005 69.3 µM -1.30820957431646 0.0859673191540381 no 3061 0.0954011177707039 4390 743608 SGTC_2053 5265679 138 µM -1.30990590498616 0.0856848142269164 no 3062 0.0951138346429944 4280 764595 SGTC_462 ag-879 158 µM -1.30995977607436 0.0856758539991995 no 3063 0.0951047217212288 4407 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2363 9053361 176 µM -1.31247474222981 0.0852583271132979 no 3064 0.0946800013801365 4425 6469797 YMR079W SEC14 SGTC_2663 amphotericin b 100 µM -1.31476374352163 0.0848796410717527 no 3065 0.0942946580313493 4402 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2827 7993847 71.43 µM -1.3202383473743 0.083979054297355 no 3066 0.0933777262467995 4431 2985692 SGTC_125 0133-0007 11.75 µM -1.32028968590848 0.0839706430633781 no 3067 0.09336915893032 4458 26541 SGTC_3056 9094900 49.47 µM -1.32114886070462 0.0838299709268762 no 3068 0.0932258669771579 4364 25236784 SGTC_2147 5545932 89.7195 µM -1.3253518944977 0.0831443608374197 no 3069 0.0925272321989446 4425 797404 SGTC_1752 st044819 83.042 µM -1.33200732778937 0.0820673461268366 no 3070 0.0914288902952811 4338 441209 YML126C ERG13 SGTC_2448 5185112 27.17 µM -1.33394597301171 0.0817556103665356 no 3071 0.0911107816798912 4390 5718189 SGTC_1676 st018489 23.4 µM -1.34140918405246 0.0805638489125388 no 3072 0.0898938186898123 4401 3696235 SGTC_301 4119-0100 24.5 µM -1.34158336774519 0.0805361919681244 no 3073 0.0898655609954764 4415 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2187 6125751 200 µM -1.34230612536053 0.0804215088924059 no 3074 0.0897483790811895 4414 874498 SGTC_1470 k295-0292 231 µM -1.34491153466344 0.0800091212927347 no 3075 0.0893269024160647 4470 5045612 SGTC_271 rotenone 740 µM -1.34560861439526 0.0798990581788312 no 3076 0.0892143860208567 4428 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2470 5664817 21.68 µM -1.34591952598137 0.0798500047542311 no 3077 0.0891642354655891 4441 2859561 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.34837112745124 0.0794640060418913 no 3078 0.0887695227664263 4393 1377 SGTC_1952 st077036 64.1 µM -1.3497849893947 0.0792420398568936 no 3079 0.088542480558666 4417 2937007 SGTC_1011 4112-3381 17.4 µM -1.3502974042763 0.0791617103907225 no 3080 0.0884603023248357 4449 2877139 SGTC_1408 3909-7976 48.8 µM -1.35245647014189 0.0788239184189442 no 3081 0.0881146675161048 4443 24152374 SGTC_562 3772-2733 112 µM -1.35313118542312 0.078718581577903 no 3082 0.0880068622283715 4392 2876874 YIL048W NEO1 SGTC_978 1416-0512 87.4 µM -1.35387797512484 0.0786021168570751 no 3083 0.0878876556687599 4454 6814003 SGTC_2457 5731572 11.68 µM -1.35470603557007 0.0784731303960068 no 3084 0.0877556170790757 4452 2865357 SGTC_384 k007-0144 5.16 µM -1.35721470515137 0.0780833359450387 no 3085 0.0873564998152458 4335 6824886 SGTC_2157 5649910 96.377 µM -1.35776496725547 0.0779980335539604 no 3086 0.0872691372507255 4388 2858091 SGTC_1896 st058441 89 µM -1.35904507437802 0.0777998631718821 no 3087 0.0870661529850351 4416 688759 SGTC_116 0155-0182 31.788 µM -1.35987824198672 0.0776710879011513 no 3088 0.0869342286783183 4271 771486 SGTC_516 3992-2719 87.3 µM -1.36192525494788 0.0773553866396434 no 3089 0.0866107375309194 4309 5350887 YDR037W KRS1 SGTC_1349 flufenamic acid 69 µM -1.3619831711933 0.077346468686937 no 3090 0.0866015980851102 4342 3371 A non-steroidal anti-inflammatory. SGTC_1559 coumarin 343 70.1 µM -1.36499472604072 0.0768838242877759 no 3091 0.0861273538182338 4453 108770 A hepatotoxic, DNA x-linker. SGTC_850 0388-0143 75.9 µM -1.37001993257709 0.0761165246751191 no 3092 0.0853403397938804 4403 67273 SGTC_421 streptovitacin 30 mM -1.37021586782208 0.0760867257928531 no 3093 0.0853097632198899 4420 91467 include heat shock SGTC_293 4049-0273 38.5 µM -1.38184310549958 0.0743342477060734 no 3094 0.0835099401836613 4291 1380311 SGTC_2260 7964312 200 µM -1.38434861944838 0.0739606805973464 no 3095 0.0831258667434492 4475 231951 SGTC_675 1309-0189 238 µM -1.39199046163531 0.0728301552342659 no 3096 0.0819626431813756 4436 4246530 SGTC_365 0121-0052 13.6 µM -1.3976719707576 0.0719982493161498 no 3097 0.0811057974908323 4432 3101739 SGTC_774 k060-0086 136 µM -1.40315625253279 0.0712021516398068 no 3098 0.0802851248891627 4428 5911235 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.41432325518759 0.0696020626628427 no 3099 0.0786335059642201 4477 6708784 An antioxidant flavonoid SGTC_760 0568-0725 82.9 µM -1.41512685698987 0.069487993334617 no 3100 0.0785156525173066 4457 3916171 SGTC_2675 theaflavin digallate 100 µM -1.41596957236779 0.069368526631714 no 3101 0.0783922066926019 4378 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1434 4073-0095 163 µM -1.41724901243029 0.0691874505995341 no 3102 0.0782050683016256 4444 24133745 SGTC_1129 3453-1384 223 µM -1.41922159834976 0.0689089892009522 no 3103 0.0779172105182414 4451 1084452 SGTC_1345 1488-0192 31.4 µM -1.42204304063949 0.0685122010500519 no 3104 0.0775068782694777 4499 658348 SGTC_701 4424-0219 185 µM -1.42640510395853 0.0679022224491687 no 3105 0.0768757206397164 4467 2911779 SGTC_1409 3909-8004 61.9 µM -1.42943179715674 0.0674814487456451 no 3106 0.0764400823616866 4496 2119279 SGTC_2987 9018338 71.43 µM -1.43062081970919 0.0673167020868379 no 3107 0.0762694586234374 4467 5055682 SGTC_1792 st045773 43.6 µM -1.43111967187005 0.0672476755945034 no 3108 0.0761979601264349 4434 2919270 SGTC_2424 5537928 59.2 µM -1.43163422521476 0.0671765338645044 no 3109 0.0761242647010513 4464 5382802 SGTC_1554 st069299 38.7 µM -1.43519040287302 0.0666864494616338 no 3110 0.0756164238327983 4413 24207999 SGTC_2404 5161160 200 µM -1.44264749899546 0.0656677601031285 no 3111 0.0745598978488414 4400 2831543 SGTC_1317 1273-0028 910 nM -1.44353205982048 0.0655477279166165 no 3112 0.0744353239972774 4473 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1105 epirubicin 18.1 µM -1.44627399546025 0.0651767365798323 no 3113 0.0740501832611994 4506 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1200 1643-0193 18.4 µM -1.44736020859743 0.065030220361851 no 3114 0.0738980321168775 4477 5403974 SGTC_3144 9087057 49.47 µM -1.45411128243376 0.0641253121249342 no 3115 0.072957728028755 4380 17249618 SGTC_623 k072-0108 16.9 µM -1.45888550632629 0.0634913101559288 no 3116 0.072298311465177 4435 5382803 SGTC_1966 st070145 16.1 µM -1.45936799956999 0.0634275089475645 no 3117 0.0722319243522551 4437 3748532 SGTC_2623 humulene 100 µM -1.45947942462153 0.0634127820479833 no 3118 0.07221659982148 4456 6187145 An anti-inflammatory. SGTC_2361 9034121 116 µM -1.47040985736864 0.0619810152828227 no 3119 0.0707253916192344 4496 6496917 SGTC_2211 7117706 200 µM -1.47046188676344 0.0619742608375336 no 3120 0.0707183504130862 4433 822771 SGTC_3014 9081533 49.47 µM -1.47151676978123 0.0618374399875381 no 3121 0.0705757078596057 4499 21367265 SGTC_951 1171-0579 82.7 µM -1.47210978509009 0.0617606280759842 no 3122 0.0704956167756331 4424 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_529 4076-0302 30.3 µM -1.47307723008941 0.0616354770472107 no 3123 0.0703651061993095 4432 5816522 SGTC_1250 0485-0349 40.2 µM -1.48211522072463 0.0604758467038256 no 3124 0.0691548197502815 4474 6842794 YDL195W SEC31 SGTC_496 calpeptin 138 µM -1.48347772526347 0.0603025194144081 no 3125 0.068973765135089 4477 73364 A calpain inhibitor. SGTC_356 1634-0012 32.5 µM -1.4872009887838 0.0598308573192777 no 3126 0.068480867500934 4479 735457 SGTC_480 am 92016 50 µM -1.49288487041064 0.0591164037489171 no 3127 0.0677336630776991 4513 2129 K+ channel blocker. SGTC_2659 sanguinarine 24.21 µM -1.49465209944896 0.0588956352706921 no 3128 0.0675026307684688 4444 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1519 esterone 74 µM -1.49591065564343 0.0587388067835543 no 3129 0.067338469577831 4474 698 A steroid. SGTC_3124 9127567 49.47 µM -1.49746056142999 0.0585461238529602 no 3130 0.0671367301081869 4444 17592030 SGTC_2678 equilin 100 µM -1.49977839572837 0.0582588991435741 no 3131 0.0668359076919089 4493 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2011 4012611 177 µM -1.50283619739284 0.057881672889932 no 3132 0.0664406445668894 4465 2049887 SGTC_857 0438-0306 1.35 µM -1.50800784444315 0.0572480445120215 no 3133 0.0657762596719434 4540 4686136 SGTC_662 k832-1615 104 µM -1.50966137738112 0.0570466099686083 no 3134 0.0655649256079683 4513 5878478 SGTC_1762 st045503 25.4615 µM -1.51362389049556 0.0565661645508887 no 3135 0.0650606291481988 4538 4645554 SGTC_1440 4100-1550 40 µM -1.51515956847624 0.0563808266784405 no 3136 0.0648659996615937 4538 742806 SGTC_2895 9054447 58.44 µM -1.52041187064733 0.0557505529332111 no 3137 0.0642037464429615 4571 2697450 SGTC_2887 9044784 58.44 µM -1.52212919072424 0.0555456857844088 no 3138 0.0639883565428947 4429 6465546 SGTC_1515 3460-0031 42.1 µM -1.52568363143785 0.0551235481203981 no 3139 0.0635443364596292 4478 2876596 SGTC_1232 0279-0259 161 µM -1.52583314540977 0.0551058470252267 no 3140 0.0635257118839026 4497 1560000 SGTC_1493 4348-0038 111 µM -1.52687508314681 0.0549826157277811 no 3141 0.0633960382801276 4496 800424 SGTC_2029 5175081 200 µM -1.52872809518629 0.054763995753014 no 3142 0.0631659321740545 4477 1380876 SGTC_948 3448-0295 75.3 µM -1.53040554307802 0.0545666821141338 no 3143 0.0629581888908495 4485 678569 SGTC_3229 9132204 49.47 µM -1.53257253806313 0.054312617104444 no 3144 0.0626906060840181 4611 17682924 SGTC_3113 9123498 49.47 µM -1.53510024114391 0.0540174451333812 no 3145 0.0623796035413248 4611 8897275 SGTC_342 k048-0088 23.3 µM -1.53550688926051 0.0539700776871175 no 3146 0.0623296830687543 4508 6820570 SGTC_1552 6-methylflavone 10.6 µM -1.53582412805434 0.0539331477120452 no 3147 0.0622907601994237 4457 689013 SGTC_308 4092-1169 104 µM -1.53747838997829 0.0537408980625614 no 3148 0.0620881014966432 4477 2268590 YDL196W YDL196W SGTC_8 0354-0001 70 µM -1.53925689069306 0.0535348158660571 no 3149 0.0618707968779899 4514 4993152 SGTC_1711 st032263 62.8 µM -1.53968944912187 0.0534847883200398 no 3150 0.0618180349394493 4509 3958979 SGTC_3354 9151612 71.43 µM -1.54226469028577 0.0531877151076649 no 3151 0.061504642831816 4499 27261949 SGTC_706 4262-0057 46.9 µM -1.54314276741879 0.0530867219629978 no 3152 0.0613980700068226 4514 883298 SGTC_2360 9040895 200 µM -1.54411397437929 0.0529751945407379 no 3153 0.0612803620240985 4535 4914414 SGTC_2409 alverine citrate 63.97 µM -1.54623599803791 0.0527321609963712 no 3154 0.0610237913070891 4532 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2755 lomerizine 42.69 µM -1.5551327515149 0.0517228390213669 no 3155 0.0599572281070606 4467 3949 A calcium channel blocker. SGTC_2465 5809242 33.21 µM -1.55604933262556 0.0516197329204558 no 3156 0.0598481809594903 4596 2731748 SGTC_1692 fluoroquinolonic acid 71 µM -1.55714069631205 0.0514971787457624 no 3157 0.0597185423308941 4532 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2332 7982454 138.89 µM -1.55898164987253 0.0512909741873267 no 3158 0.0595003616972062 4434 2981748 SGTC_471 1-acyl-paf 4 µM -1.56055706204521 0.0511150348750121 no 3159 0.0593141482452229 4498 16759367 SGTC_2817 7995342 71.43 µM -1.5679259010296 0.050298463602859 no 3160 0.0584492131461748 4509 18879975 SGTC_2189 6047310 154.431 µM -1.5679432413388 0.0502965543864499 no 3161 0.0584471895304783 4527 711535 SGTC_2724 maprotiline 69.64 µM -1.57201764803715 0.0498495496455208 no 3162 0.0579732292123083 4474 4011 A tricyclic antidepressant. SGTC_2248 tofa 1.1 µM -1.57701644861631 0.0493054643768748 no 3163 0.0573958701772164 4553 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.57714066865138 0.0492920044951938 no 3164 0.057381580640845 4555 390807 SGTC_128 0906-2981 13.371 µM -1.57814140199719 0.049183676869745 no 3165 0.0572665642937646 4526 6740226 SGTC_1838 st055369 84.5 µM -1.57840456449729 0.0491552215871985 no 3166 0.0572363486323838 4510 676036 SGTC_2851 9015922 71.43 µM -1.58008104199455 0.0489742556804413 no 3167 0.0570441541344565 4542 2996893 SGTC_651 3253-0966 34.4 µM -1.58150141739129 0.0488213513585067 no 3168 0.0568817175596948 4559 781462 SGTC_1165 k072-0275 30.3 µM -1.58370949135681 0.0485844085715197 no 3169 0.0566299219549621 4524 6153523 YGL055W OLE1 SGTC_1073 triclabendazole 3.09 µM -1.58492822557102 0.048454023611193 no 3170 0.0564913213422606 4576 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2930 9013230 14.89 µM -1.58520353109035 0.0484246091279768 no 3171 0.0564600492520686 4512 2995857 SGTC_77 0828-0286 12.516 µM -1.58542213869244 0.0484012625969073 no 3172 0.0564352272254524 4431 745345 SGTC_1743 st037606 46.3785 µM -1.58805444400709 0.0481208478026427 no 3173 0.0561370142275989 4494 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_732 3970-1727 52.7 µM -1.59847621380321 0.0470233748754855 no 3174 0.0549685174782298 4605 1275699 SGTC_967 1306-0166 352 µM -1.60194214779643 0.0466628710948608 no 3175 0.0545842015428076 4543 4437607 SGTC_57 miconazole 162.5 nM -1.60220131402778 0.0466360036748384 no 3176 0.0545555498011718 4383 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_552 k242-0005 476 µM -1.60451261777267 0.0463969424966136 no 3177 0.0543005527267058 4591 4088318 SGTC_2954 9074818 52.69 µM -1.60837554751311 0.0459995915982212 no 3178 0.0538764768774721 4550 16648742 SGTC_974 1326-0144 138 µM -1.6203328570445 0.0447869353818022 no 3179 0.0525803972233984 4562 5411856 SGTC_420 mitomycin C 81.9 mM -1.62058687526104 0.0447614559693231 no 3180 0.0525531344443968 4530 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_981 1488-1094 54.9 µM -1.62139217229051 0.0446807574351957 no 3181 0.0524667792305856 4528 3449522 SGTC_2605 digitonin 300 nM -1.62259594257781 0.0445603465622535 no 3182 0.0523379042205156 4541 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_219 mitoxanthrone 164.414 µM -1.62786756007849 0.0440361122127828 no 3183 0.0517764856371689 4512 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1358 1509-0022 2.48 µM -1.62832186661555 0.0439911675787634 no 3184 0.0517283276288262 4586 3258434 SGTC_964 1287-0107 19.4 µM -1.63158633151255 0.0436693003502671 no 3185 0.0513833297883449 4552 51516812 YPR165W RHO1 SGTC_566 0958-0068 16.5 µM -1.63275905350043 0.0435541381891525 no 3186 0.0512598409808807 4469 6815365 SGTC_3068 9116768 49.47 µM -1.63385782039029 0.0434464610084073 no 3187 0.0511443540759444 4527 41904888 SGTC_2342 7990637 118.86 µM -1.63506159662828 0.043328739893872 no 3188 0.0510180678382646 4547 2033102 YER133W GLC7 SGTC_573 3702-0553 84.7 µM -1.63757708646527 0.0430835735519894 no 3189 0.050754973085203 4503 1222756 SGTC_583 1488-1091 88.9 µM -1.64618490489528 0.0422530994861038 no 3190 0.0498628480568246 4662 4303273 SGTC_2122 5258151 111.688 µM -1.6476417368244 0.0421138357664785 no 3191 0.0497131052321515 4577 2173356 SGTC_2957 9076800 11.52 µM -1.65033077162782 0.0418577572034379 no 3192 0.0494376509277717 4553 16459615 SGTC_154 3389-1638 511.116 µM -1.6539643834586 0.0415137304449847 no 3193 0.0490673747933306 4567 5238686 SGTC_1354 1498-1681 81 µM -1.65660281273145 0.0412653651572884 no 3194 0.0487999016605501 4596 5754243 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.65844555047594 0.0410926167743929 no 3195 0.0486137845397797 4560 688803 SGTC_170 4197-0004 226 µM -1.66109028785675 0.040845709813824 no 3196 0.0483476573754531 4578 218692 SGTC_3324 9138759 60.749 µM -1.66291804511558 0.040675778713361 no 3197 0.0481644208622956 4578 45595710 SGTC_2951 9072950 58.06 µM -1.66559864679741 0.0404275947948527 no 3198 0.0478966904280157 4499 16488155 SGTC_3066 9117245 49.47 µM -1.66954996823155 0.0400640044625702 no 3199 0.0475042181395979 4610 17176980 SGTC_1297 1068-0111 14.1 µM -1.67361555997319 0.0396926771624019 no 3200 0.0471030892423672 4571 767057 SGTC_615 k087-0205 167 µM -1.67385082077871 0.0396712757593784 no 3201 0.0470799607617754 4588 9642773 SGTC_841 0251-0215 91.2 µM -1.67689114847764 0.0393955439230166 no 3202 0.0467818846749206 4612 3888614 SGTC_1272 0839-0021 27 µM -1.68426415748321 0.0387333467545857 no 3203 0.0460653145209024 4628 5027250 SGTC_1758 st042942 75.2445 µM -1.68806479005476 0.0383955562008031 no 3204 0.0456993962306205 4568 669317 SGTC_962 1254-0300 21.5 µM -1.68829609521577 0.038375076151661 no 3205 0.0456772022135879 4564 7340576 SGTC_717 1532-0246 73.2 µM -1.69190765746364 0.0380564574053063 no 3206 0.04533179086799 4585 9561992 SGTC_2444 5485484 36.41 µM -1.70109572818735 0.0372555887195173 no 3207 0.0444625064741352 4623 6790631 SGTC_2311 7694451 200 µM -1.70375499569993 0.0370263830592002 no 3208 0.044213434486345 4578 2163142 SGTC_2373 9071805 200 µM -1.70878414956086 0.0365960653119603 no 3209 0.0437454699180544 4590 10149009 SGTC_1933 st074711 15.9 µM -1.71254539465745 0.036276917057088 no 3210 0.0433981032350654 4588 17250958 SGTC_180 1486-1293 102.781 µM -1.72700209542176 0.0350713828927946 no 3211 0.042083643577291 4526 4140536 SGTC_1460 k062-0059 9.15 µM -1.73354487490825 0.0345366943720953 no 3212 0.0414994343360211 4491 1373085 SGTC_882 0843-0131 351 µM -1.73896429546154 0.0340988959215563 no 3213 0.0410205217349253 4622 5425421 SGTC_2312 7706453 155.7 µM -1.74271921196581 0.0337982456493538 no 3214 0.0406913370380203 4587 976098 SGTC_2365 9042475 200 µM -1.74529321913634 0.0335934115114354 no 3215 0.0404669208378397 4617 6464479 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.75490859449852 0.0328372581077645 no 3216 0.0396374719265615 4609 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_278 4092-0821 23.9 µM -1.75871932701253 0.0325414899673082 no 3217 0.0393125965040841 4594 877900 SGTC_2047 4141938 200 µM -1.76452167030973 0.0320953668868282 no 3218 0.0388220950917616 4631 3807862 SGTC_1273 0849-0096 14.1 µM -1.77049556935778 0.0316413413339171 no 3219 0.0383223109120083 4627 5286025 SGTC_124 0136-0217 7.121 µM -1.77676687614451 0.03117043623061 no 3220 0.0378033019469226 4663 3976905 SGTC_1008 4106-0037 6 µM -1.78307191643562 0.0307028572709923 no 3221 0.0372872986431523 4645 2905394 SGTC_59 0330-0160 1.33 µM -1.7914988100095 0.0300870053546199 no 3222 0.0366066426960174 4583 4293482 SGTC_279 1273-0055 2.93 µM -1.79159884065495 0.0300797569089303 no 3223 0.036598624491955 4664 2847562 SGTC_3016 9080866 49.47 µM -1.79480435096982 0.0298482439091162 no 3224 0.0363424386784889 4615 17066299 SGTC_2313 7726885 200 µM -1.79945257913793 0.029515160170751 no 3225 0.0359735593745451 4611 726423 SGTC_2279 7948423 32.93 µM -1.80044694551787 0.0294443077460157 no 3226 0.0358950468849028 4556 1247112 SGTC_2826 7992541 19.48 µM -1.80929437171152 0.0288200914087489 no 3227 0.0352026414637178 4618 2985066 SGTC_652 0437-0092 114 µM -1.81322350702781 0.0285464262833789 no 3228 0.0348986778141496 4612 3091274 SGTC_291 SEC14.278 35.5 µM -1.82264703641181 0.027898875138252 no 3229 0.0341784333876602 4653 1068044 SGTC_807 1315-0151 48 µM -1.82628745688863 0.0276520168538083 no 3230 0.0339034867991516 4629 4011080 SGTC_2995 9067767 71.4286 µM -1.82982575448054 0.0274138308302779 no 3231 0.0336379991830777 4616 11673567 SGTC_2145 5634607 200 µM -1.8314894694749 0.0273024280062652 no 3232 0.0335137590287374 4647 308662 SGTC_741 4582-0002 126 µM -1.83302834654316 0.0271997207777957 no 3233 0.0333991778450754 4650 2912688 SGTC_3237 9133362 49.47 µM -1.83523898415307 0.0270527434036987 no 3234 0.0332351436256396 4633 43845137 SGTC_2702 st077768 96.8 µM -1.83668654087707 0.0269568601091464 no 3235 0.0331280916535118 4598 6484119 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.84966583238529 0.0261097468136857 no 3236 0.0321808639876503 4616 521171 SGTC_2802 7925815 54.55 µM -1.86778469846973 0.0249645185451533 no 3237 0.0308960435645497 4627 1262923 SGTC_2989 9073649 71.4286 µM -1.86910638484629 0.0248826538102213 no 3238 0.0308040074513104 4600 21367202 SGTC_1353 1498-1206 8.11 µM -1.87024569671541 0.0248122660663412 no 3239 0.0307248533114776 4655 6756808 SGTC_2943 9068529 45.32 µM -1.87716457482172 0.0243883889107091 no 3240 0.0302477705790903 4600 3270634 SGTC_598 3937-0236 20.2 µM -1.87722423317325 0.0243847606128177 no 3241 0.0302436837630213 4694 1379313 SGTC_366 0181-0206 4.31 µM -1.88102917299054 0.0241542863887248 no 3242 0.0299839752589315 4624 274874 SGTC_2065 5221596 34.26 µM -1.88333087237997 0.0240157572795807 no 3243 0.0298277710468147 4623 788581 SGTC_1392 3455-1037 33.9 µM -1.88448275120595 0.023946681807574 no 3244 0.0297498529043609 4658 981132 SGTC_1878 temozolomide 1 mM -1.88581667045117 0.0238668985099183 no 3245 0.0296598318456323 4624 5394 DNA alkylating agent. SGTC_1909 st060837 51.5 µM -1.88780607229686 0.0237483251926879 no 3246 0.0295259948504147 4602 678937 SGTC_2596 sinensetin 100 µM -1.89505652801189 0.0233203636721959 no 3247 0.0290424565464507 4629 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2349 9023730 187.07 µM -1.89818744676416 0.0231375764339164 no 3248 0.0288356969357205 4664 4126287 SGTC_2452 5863136 48.41 µM -1.9097126408564 0.0224750801875762 no 3249 0.028085111247719 4623 2184096 SGTC_3242 9133940 49.47 µM -1.91046369837556 0.022432468467449 no 3250 0.0280367680579064 4665 17248444 SGTC_2593 nobiletin 86.24 µM -1.91310158581629 0.0222833457901209 no 3251 0.0278675243956249 4633 72344 An anti-infammatory. SGTC_275 trichlorophene 5.69 µM -1.92783099751067 0.0214659655692871 no 3252 0.0269380753860191 4685 62616 SGTC_2915 7971052 15.16 µM -1.9299494830517 0.0213505153323213 no 3253 0.0268065486770573 4635 5741558 SGTC_1326 1431-2094 10.8 µM -1.93425117716652 0.0211177025133066 no 3254 0.0265411264319986 4673 616278 SGTC_3116 9124943 49.47 µM -1.93709595622605 0.0209649224281769 no 3255 0.0263668074241708 4642 41905195 YPL160W CDC60 SGTC_611 3453-1652 23.7 µM -1.94456109041552 0.020568446220746 no 3256 0.0259139130636756 4663 1560575 SGTC_935 2996-0153 430 µM -1.94650089319712 0.0204664684276081 no 3257 0.025797300377206 4662 23738523 SGTC_1742 st038235 28.8875 µM -1.94946024440227 0.0203117172725896 no 3258 0.0256202430302492 4684 564103 YBR002C RER2 SGTC_586 0957-0265 8.15 µM -1.95120047703956 0.0202211805571607 no 3259 0.0255166011346787 4593 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2219 9098279 200 µM -1.96413211457514 0.0195590633148474 no 3260 0.024757386404292 4644 902349 SGTC_2543 pimpinellin 60.67 µM -1.97109389407414 0.0192102986181211 no 3261 0.0243565685104966 4569 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1655 st012546 55.1 µM -1.97827215561497 0.018856238300324 no 3262 0.0239490062633119 4680 720985 YLR208W SEC13 SGTC_2194 5927483 104.545 µM -1.9824943316483 0.0186505884665235 no 3263 0.0237119705869096 4704 760979 SGTC_2592 piperlongumine 83.33 µM -1.98268079839067 0.018641550409497 no 3264 0.0237015478710376 4660 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_474 dl-dihydrosphingosine 5 µM -1.98586938027747 0.0184875756336079 no 3265 0.0235239147255037 4656 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1497 4476-2978 41.3 µM -1.98611937520346 0.018475549440975 no 3266 0.0235100351931575 4713 1528379 SGTC_2082 5219693 150 µM -1.99048183919152 0.0182667599108695 no 3267 0.0232689412970596 4660 2834649 SGTC_569 4130-2812 160 µM -1.99255248073071 0.0181683637452673 no 3268 0.023155236515046 4623 743552 SGTC_432 NS 1619 61.3 µM -1.99445762002413 0.0180782315514623 no 3269 0.0230510334932958 4635 4552 A K+/calcium channel activator. SGTC_475 α-linolenic acid 10 µM -2.02160273265029 0.0168348378218953 no 3270 0.0216087047672549 4691 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2844 9010103 25.97 µM -2.03397640387971 0.0162927818929068 no 3271 0.020976987293653 4643 2480525 SGTC_50 0929-0078 56.389 µM -2.03544855426543 0.0162292972301015 no 3272 0.0209028800137058 4578 1377751 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.03554374369221 0.016225199607821 no 3273 0.0208980958652202 4657 6857784 SGTC_1462 k081-0014 26.5 µM -2.03604046883198 0.0162038314412562 no 3274 0.0208731458711736 4139 3270634 SGTC_2799 7812892 81.82 µM -2.03807118742465 0.016116724377044 no 3275 0.020771407067521 4681 20205235 SGTC_1074 carmofur 3.8 µM -2.04118194012636 0.0159840677892811 no 3276 0.0206163730620074 4736 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2699 st077704 54.6 µM -2.04315168407662 0.0159005538578083 no 3277 0.0205187124647875 4686 645852 SGTC_2921 7974240 10.71 µM -2.04451202765314 0.0158430961603022 no 3278 0.0204514952114363 4705 2979074 YDR527W RBA50 SGTC_1921 5740136 50 µM -2.04924262978119 0.01564467079735 no 3279 0.0202191977260691 4635 1774243 SGTC_274 sirtinol 40.1 µM -2.05698655219381 0.0153244536893063 no 3280 0.019843759724442 4719 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_449 xestospongin c 11.1929 µM -2.05819945679021 0.0152748124792494 no 3281 0.019785495373288 4707 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1417 3966-0327 90.4 µM -2.05938320208406 0.0152264979237633 no 3282 0.0197287718240114 4746 651118 SGTC_136 0097-0015 404.482 µM -2.07558026652595 0.014578488483625 no 3283 0.0189663940523772 4694 4861337 SGTC_1117 retinoic acid 1.10837 µM -2.08399651540492 0.0142512432991887 no 3284 0.0185802421147974 4729 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_208 k072-0098 12.366 µM -2.09117161368136 0.0139772731981664 no 3285 0.01825634147732 4712 5948901 SGTC_2054 5233173 129 µM -2.09906582444794 0.01368110225022 no 3286 0.017905549286224 4699 6889 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -2.10402183568186 0.0134979450353093 no 3287 0.0176882711562253 4692 6312947 SGTC_2938 9059746 27.26 µM -2.10718809315501 0.0133820424172559 no 3288 0.0175506393113469 4669 6471769 SGTC_2370 9071495 200 µM -2.1098044217013 0.0132869197263368 no 3289 0.0174376027281342 4722 21791103 SGTC_391 gliotoxin 8.33 µM -2.11579644641608 0.0130712638513292 no 3290 0.0171810617369307 4720 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_229 benomyl 22.8748 µM -2.12432359508471 0.012769587120123 no 3291 0.0168215470168701 4730 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_597 k018-0003 82.8 µM -2.1320361142787 0.0125019374349099 no 3292 0.0165019388958393 4743 6786234 SGTC_2153 5569715 200 µM -2.13975534421229 0.0122389322493277 no 3293 0.0161872719024123 4739 2054701 SGTC_2334 9017922 200 µM -2.17569594183881 0.0110765626040237 no 3294 0.0147890019276512 4705 3163164 SGTC_1159 4092-0538 61.2 µM -2.17642580653126 0.0110539882530005 no 3295 0.0147617179331084 4741 717301 SGTC_324 1315-0088 19.6 µM -2.18389158474723 0.0108253641382954 no 3296 0.0144851077684752 4722 6787421 SGTC_3145 9085516 49.47 µM -2.18728991121318 0.0107226678653948 no 3297 0.0143606833813763 4686 25236195 SGTC_2008 4012253 172 µM -2.21344725726124 0.00996020714315035 no 3298 0.0134334128337291 4712 603940 SGTC_258 haloperidol 50.781 µM -2.24097743996124 0.00920927243738284 no 3299 0.0125137681885004 4729 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2126 5251174 33.877 µM -2.24153108395286 0.00919469343849211 no 3300 0.0124958471913491 4699 790722 SGTC_3187 9109394 49.47 µM -2.24607713598497 0.00907574518133374 no 3301 0.0123495337836391 4718 17098090 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.24762811699005 0.0090354729053568 no 3302 0.0122999565650193 4728 6710655 SGTC_1153 4055-0057 267 µM -2.25478659507446 0.0088516196629164 no 3303 0.0120733635434579 4751 882706 SGTC_2401 5128683 200 µM -2.25898401809037 0.00874534785633889 no 3304 0.0119421895184704 4707 708373 SGTC_2549 cedrol 20.94 µM -2.29534340192952 0.0078706401370139 no 3305 0.0108567260759171 4726 6708665 A sedative which affects the nervous system. SGTC_2964 9083345 53.42 µM -2.31242697937711 0.00748692131454385 no 3306 0.0103770825072267 4715 17741579 SGTC_1099 5-nonyloxytryptamine 2.85 µM -2.34463703159268 0.00680805231323917 no 3307 0.0095228052303242 4755 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1961 st076550 68.7 µM -2.36083408302909 0.00648768816632021 no 3308 0.00911694321626653 4747 1579337 SGTC_788 1182-0090 188 µM -2.36581007114029 0.00639198193349191 no 3309 0.00899533557310129 4726 5715185 SGTC_86 0417-1630 471.922 µM -2.37423809942698 0.00623272834509116 no 3310 0.00879260331553539 4752 3634867 SGTC_1179 1021-1431 9.29 µM -2.37870096464284 0.00614983053311624 no 3311 0.00868688185875646 4753 2840958 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.40159793536858 0.00573969407434693 no 3312 0.00816181945868972 4756 688664 SGTC_775 4577-0580 57.3 µM -2.4227865846281 0.00538197677854884 no 3313 0.00770098598035423 4740 2006902 SGTC_2484 5809818 12.04 µM -2.42348995553351 0.00537044975208138 no 3314 0.00768608918093749 4730 2870548 SGTC_1913 st060213 96.1 µM -2.44838151795488 0.00497639821512192 no 3315 0.00717498086279213 4732 688959 SGTC_2883 9059145 45.46 µM -2.45387488540709 0.00489298415087674 no 3316 0.00706630716883057 4758 16476510 SGTC_2556 citropten 84.59 µM -2.46736038942585 0.00469347429759559 no 3317 0.00680566439172535 4728 2775 A potential DNA crosslinker. SGTC_1058 3448-5425 97.3 µM -2.47152593302257 0.00463333187375229 no 3318 0.00672688964669597 4735 7279705 SGTC_2377 9073351 62.6 µM -2.47651653454757 0.00456218338847843 no 3319 0.0066335739832964 4743 7337946 YHR072W ERG7 SGTC_1824 st053723 68.6 µM -2.49653796428919 0.00428645393629403 no 3320 0.00627061217630309 4769 675225 SGTC_619 1652-1634 108 µM -2.52886275885089 0.00387262835696858 no 3321 0.0057216381774381 4749 5400454 SGTC_2750 bromebric acid 70.15 µM -2.53411603155346 0.00380886650345565 no 3322 0.0056365698368766 4757 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_10 0279-0212 42.575 µM -2.5380250903426 0.00376203250908926 no 3323 0.00557399958940185 4781 39851 YBR002C RER2 SGTC_1579 chlormadinone acetate 49.4 µM -2.53841409350678 0.00375740027239644 no 3324 0.00556780689899181 4787 45114258 A steroidal progestin. SGTC_797 k781-0471 270 µM -2.5533852499507 0.00358296505832005 no 3325 0.00533407124004529 4752 23738129 SGTC_907 3448-6986 75.5 µM -2.56866811953844 0.00341242966246054 no 3326 0.00510450891321542 4757 590582 SGTC_270 tamoxifen 5.46 µM -2.58924260759726 0.0031943720407305 no 3327 0.00480936505443592 4760 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2163 5671233 125 µM -2.59281336412529 0.0031578309322582 no 3328 0.00475972072092472 4763 701023 SGTC_481 bay k-8644 50 µM -2.63413067471358 0.00276155834908504 no 3329 0.00421765083482569 4770 2303 A calcium channel antagonist. SGTC_2110 5483698 200 µM -2.63867225855954 0.00272085908150089 no 3330 0.00416157015701547 4760 2848765 YHR062C RPP1 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.64733578182618 0.00264471972803525 no 3331 0.00405643761883721 4786 688788 SGTC_2357 9067248 200 µM -2.67665400363427 0.00240112104575747 no 3332 0.00371806912283011 4734 9150235 SGTC_2928 9011484 9.79 µM -2.67704570933668 0.00239800862060165 no 3333 0.00371372506138305 4744 2994751 SGTC_209 4077-0173 175.592 µM -2.70370433121438 0.00219457034148803 no 3334 0.00342856370023314 4752 15993494 SGTC_3110 9122132 49.47 µM -2.71423715776662 0.0021185996821242 no 3335 0.00332142957924028 4768 918317 SGTC_2772 vinpocetine 57.06 µM -2.71940093832507 0.00208223295819534 no 3336 0.00327001406589333 4765 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_11 0438-0307 1.3 µM -2.78209586776789 0.00168370654532415 no 3337 0.00270045417829976 4776 4011476 SGTC_2339 9000433 200 µM -2.783029464874 0.00167833638669883 no 3338 0.00269269575448487 4760 2988954 SGTC_2333 9017922 200 µM -2.88404144586574 0.00118147471521579 no 3339 0.00196303539028555 4761 3163164 SGTC_325 2810-4341 181 µM -2.92431413414406 0.00102410557496214 no 3340 0.00172608086177567 4796 774970 SGTC_1922 5578187 25 µM -2.98558374542678 0.000821252739485159 yes 3341 0.0014151881311342 4783 1350412 SGTC_3303 9125618 40.5795 µM -2.9910689398168 0.000805026965214656 yes 3342 0.00139001361909627 4774 22695467 SGTC_2454 5-benzylidenerhodanine 10.36 µM -3.03710962368503 0.000680024251621171 yes 3343 0.00119429285560987 4793 1273210 SGTC_2873 9040596 71.43 µM -3.0605722577336 0.000623452666063077 yes 3344 0.0011045722390108 4785 6463863 SGTC_1631 benzylvanillin 81.9 µM -3.15283541730453 0.000440574926964336 yes 3345 0.000808464711502766 4784 75506 SGTC_1363 1636-0063 10.4 µM -3.16085369595445 0.000427297924436883 yes 3346 0.000786537448409184 4796 6072185 SGTC_204 PMA1.184 62.41 µM -3.25722817797004 0.000294230627266057 yes 3347 0.000562529773852051 4796 2252213 YGL008C PMA1 SGTC_2804 7954240 19.48 µM -3.32150566710881 0.000228154841479754 yes 3348 0.000447665820788504 4784 828705 SGTC_923 1900-2434 73.3 µM -3.46755665727212 0.000125932965955531 yes 3349 0.000262606505310801 4783 5910570 SGTC_577 r071-0003 38.6 µM -3.52925364896009 9.73062364613211e-05 yes 3350 0.000208366748656011 4802 4568517 YMR134W ERG29 SGTC_2123 5259487 200 µM -3.55077189558364 8.88510355186444e-05 yes 3351 0.000192051580215418 4802 2173474 SGTC_2460 5552655 174.22 µM -3.6577789750153 5.61233086423635e-05 yes 3352 0.000127205142883047 4798 5401989 SGTC_3140 9094243 49.47 µM -3.7467544848669 3.79472984230727e-05 yes 3353 8.95686299218634e-05 4795 19291112 SGTC_2459 5811157 9.22 µM -3.93229165056786 1.63254043850221e-05 yes 3354 4.20699480344927e-05 4807 2870684 YBR192W RIM2 SGTC_433 pimozide 108 µM -4.10697781132496 7.13222949114895e-06 yes 3355 2.00434860771927e-05 4800 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic