SGTCid condition conc unit RAD17|YOR368W.score RAD17|YOR368W.strain.pval RAD17|YOR368W.strain.significant RAD17|YOR368W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1126 isoteolin 1.0172 µM 6.58779290159779 1.12361657461487e-11 yes 1 2.23206362123379e-11 5 133323 SGTC_967 1306-0166 352 µM 5.28299417963889 4.14882647207181e-08 yes 2 6.35447153366024e-08 9 4437607 SGTC_301 4119-0100 24.5 µM 4.97783634042411 2.21085670294022e-07 yes 3 3.21494934514128e-07 55 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1670 st016595 4.04 µM 4.67530472297826 1.05899191385383e-06 yes 4 1.46758729036091e-06 4 597879 SGTC_950 1165-0508 94.1 µM 4.59460956753221 1.58358328861697e-06 yes 5 2.16780136625001e-06 15 6148369 SGTC_405 ebelactone b 50 µM 4.53439367873554 2.12912221216382e-06 yes 6 2.88845962475371e-06 4 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1124 fisetin 1.16336 µM 4.13316482826298 1.39563087968311e-05 yes 7 1.78900966950063e-05 30 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2508 celastrol 40.54 µM 3.91096630883356 3.69087171473923e-05 yes 8 4.59637980255181e-05 19 122724 Celastrol is a natural product and antioxidant. SGTC_1738 st035555 74 µM 3.86826232122247 4.42458766760217e-05 yes 9 5.48068543136368e-05 33 5331140 SGTC_1761 st044296 37 µM 3.84181641347375 4.94590502671924e-05 yes 10 6.10635850406216e-05 17 1826700 SGTC_473 2-arachidonoylglycerol 10 µM 3.77838375954437 6.44245925652039e-05 yes 11 7.89247508313252e-05 22 5282280 An endocannabinoid. SGTC_2088 5278280 127.392 µM 3.74721642458118 7.3253826742146e-05 yes 12 8.94039009947806e-05 29 791502 SGTC_3025 9087895 49.47 µM 3.70599245682975 8.66900098672032e-05 yes 13 0.000105282282895827 46 17173641 SGTC_2302 7771753 200 µM 3.51662881459889 0.000183916498958289 yes 14 0.000218532261728811 57 2203047 SGTC_1424 4048-1941 275 µM 3.43473937382156 0.000251856571868738 yes 15 0.000296561985561006 39 X1424 SGTC_1073 triclabendazole 3.09 µM 3.4262096086786 0.000260142349246342 yes 16 0.000306033924200287 49 50248 An antihelmetic and likely tubulin inhibitor. SGTC_845 0330-0138 4.51 µM 3.40830564603325 0.000278367105601867 yes 17 0.000326838159222777 34 9039800 SGTC_2899 9053889 58.44 µM 3.38783300913804 0.000300661061791157 yes 18 0.000352235705188312 22 6470052 SGTC_858 0438-0351 2.77 µM 3.38599607330684 0.000302740609652386 yes 19 0.00035460199213525 38 2799119 SGTC_1243 0416-0003 5.65 µM 3.36888922670898 0.000322759891010668 yes 20 0.000377358768928716 59 2141977 SGTC_345 1362-0200 395 µM 3.31750080313463 0.000390545178600441 yes 21 0.000454133272659432 37 1419823 SGTC_3205 9113483 49.47 µM 3.31688517793095 0.000391432010111409 yes 22 0.000455135089607408 59 17018033 SGTC_2399 5884133 200 µM 3.29092834695241 0.000430570061202021 yes 23 0.000499286724309723 109 722445 SGTC_1739 st037196 92.5 µM 3.27914501847051 0.000449508636401795 yes 24 0.000520610572499453 52 612214 SGTC_1841 st054148 70 µM 3.21620198416223 0.000564421700744776 yes 25 0.000649496854405372 32 675442 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 3.20455754873715 0.000588451334879799 yes 26 0.000676351225958535 35 688801 SGTC_361 000s-0510 1.45 µM 3.19081783852874 0.000618019221950596 yes 27 0.000709353491446971 65 660 SGTC_1608 st001473 40.5 µM 3.18923585529154 0.000621510340777035 yes 28 0.000713247197177001 65 7292267 SGTC_2595 hexamethylquercetagetin 100 µM 3.16992443082563 0.000665620212660493 yes 29 0.000762392939280021 58 386331 SGTC_122 0236-0016 402.397 µM 3.15844437915417 0.00069319312413916 yes 30 0.000793067867498196 82 6808838 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 3.15481400398407 0.000702129430247714 yes 31 0.000803002270040877 72 2374 Ca(2+)-ATPase inhibitor. SGTC_3002 9075603 71.4286 µM 3.15204516846726 0.000709016293614968 yes 32 0.000810655956072312 58 20105405 SGTC_1678 st019265 80.2 µM 3.15084586572751 0.000712018577853229 yes 33 0.000813991891723666 54 5367020 SGTC_1994 st072947 40.9 µM 3.1499774055598 0.000714199956148028 yes 34 0.000816415449780004 49 5286565 YDL195W SEC31 SGTC_1657 st012939 43.4 µM 3.13645610663851 0.000748966797067231 yes 35 0.000855015158887455 32 24207257 SGTC_496 calpeptin 138 µM 3.12968609795506 0.000766954011556604 yes 36 0.000874965947768625 46 73364 A calpain inhibitor. SGTC_2905 7799065 20.05 µM 3.11551172971924 0.000805909257162374 yes 37 0.000918130227275669 34 1296806 SGTC_2524 avocatin b 10.57 µM 3.08953922967208 0.000882050467305623 yes 38 0.00100233615165818 49 6710748 SGTC_2902 5787006 60.46 µM 3.05581273145372 0.000990793114474728 yes 39 0.00112225697872749 57 591003 SGTC_1191 1487-1166 10.6 µM 3.02550956487184 0.00109885531292817 no 40 0.00124107276843268 68 3955771 SGTC_2112 5488546 200 µM 3.01621233734362 0.00113411371273872 no 41 0.00127976975800399 58 600757 SGTC_2009 4012297 12.05 µM 2.96519898169807 0.00134670200997456 no 42 0.00151243604864906 115 45595307 SGTC_2136 5328288 199.296 µM 2.94307542659482 0.00144974624507256 no 43 0.00162484615982474 53 262395 SGTC_2328 6201408 200 µM 2.9260592541847 0.00153384359377996 no 44 0.00171642772949545 59 2890418 SGTC_577 r071-0003 38.6 µM 2.88422959290465 0.0017598139082395 no 45 0.00196186285723446 133 4568517 YMR134W ERG29 SGTC_582 0987-0078 156 µM 2.87400972135881 0.00181944195368872 no 46 0.00202648243870799 162 1625765 SGTC_1160 4092-0570 10.5 µM 2.8447698853921 0.00200032979602384 no 47 0.00222217588034762 98 4994975 SGTC_1506 4226-2149 212 µM 2.83863503157324 0.00204029487126306 no 48 0.00226534725536411 97 991114 SGTC_346 4513-0042 7.16 µM 2.83810950222626 0.0020437518700254 no 49 0.00226908054214373 91 2827372 SGTC_1772 st048439 82.2 µM 2.82478557099679 0.00213319362353111 no 50 0.00236561334075413 88 2927068 YDL195W SEC31 SGTC_2860 9025725 38.96 µM 2.81266045426316 0.00221765731668924 no 51 0.00245667516317341 55 40546248 SGTC_2461 5755302 26.15 µM 2.81219770710311 0.00222094004725615 no 52 0.00246021246300202 103 2788904 SGTC_2753 fluvastatin 17.09 µM 2.80406811796754 0.00227933420998036 no 53 0.00252311212972508 92 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_247 mechlorethamine 29.705 µM 2.80134331256917 0.00229921524937027 no 54 0.00254451737964686 54 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2474 5321570 43.32 µM 2.79308870660898 0.00236040566585086 no 55 0.00261036865275632 69 2841384 SGTC_1018 4259-0013 28.1 µM 2.75039920855975 0.00270101627990104 no 56 0.00297613499910751 74 6801262 SGTC_303 1348-1668 34.2 µM 2.73062382646992 0.00287335259484179 no 57 0.00316072902718965 53 5380509 SGTC_814 3342-0569 96 µM 2.71357850939556 0.00302978710547421 no 58 0.00332803971062144 97 4346283 SGTC_126 0417-1624 672.48 µM 2.70695381345451 0.00309262753401815 no 59 0.00339518518274957 123 41912 YDL195W SEC31 SGTC_2121 5257820 149.641 µM 2.70559667684195 0.00310564496370419 no 60 0.00340908994553822 72 791256 SGTC_1255 0566-0045 221 µM 2.68126317093447 0.0033475731396414 no 61 0.00366724048823741 118 2788469 SGTC_1246 0422-0085 105 µM 2.67870377836129 0.00337397918492434 no 62 0.00369538726019777 120 264295 SGTC_1403 3909-7815 62.9 µM 2.66805684835948 0.00348584748839863 no 63 0.00381456741053798 73 6615483 SGTC_1689 st020265 53.493 µM 2.6644976525541 0.00352398063146295 no 64 0.00385517022573859 72 5758320 YPR016C TIF6 SGTC_2073 5212005 126 µM 2.63556351428564 0.0038481466960033 no 65 0.00419988520222031 45 691789 SGTC_74 000s-0487 160.283 µM 2.63349848662439 0.00387227341451741 no 66 0.00422551061707438 94 677548 SGTC_3045 9092950 49.47 µM 2.63073814319254 0.00390473551526222 no 67 0.00425998271771458 94 44120432 SGTC_2955 9076254 12.21 µM 2.61437574214653 0.00410221496589775 no 68 0.00446953346441498 69 16459619 SGTC_2606 farnesol 9.78 µM 2.61318977667555 0.0041168700325126 no 69 0.00448507388046088 101 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_726 3448-4391 34.2 µM 2.60082878439 0.00427242764559909 no 70 0.00464994279232131 99 1356692 SGTC_2148 5546263 113.568 µM 2.58505776414949 0.00447851837640189 no 71 0.0048681342100802 96 792097 SGTC_354 2783-3500 4.88 µM 2.57789653304409 0.00457499607235587 no 72 0.0049701878567262 146 6740761 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.56821230378505 0.00470841374288057 no 73 0.00511122635659779 83 756377 SGTC_851 0394-0702 453 µM 2.54771045441763 0.0050023722525918 no 74 0.00542162136561069 96 762646 SGTC_1676 st018489 23.4 µM 2.52829126018905 0.00529576800443116 no 75 0.00573096106901315 132 3696235 SGTC_2089 5281248 129.67 µM 2.52569244380062 0.00533617177515739 no 76 0.00577352598976405 119 2737878 SGTC_2926 9010726 65.15 µM 2.51152634725228 0.00556126841035159 no 77 0.00601051560518129 128 2994293 SGTC_927 2425-1185 123 µM 2.51070829974613 0.00557452093157729 no 78 0.00602446068743417 111 730375 SGTC_1545 lovastatin 49.4 µM 2.50825169837597 0.0056144870850445 no 79 0.00606651037611627 141 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1898 st060199 18.6 µM 2.50776275999511 0.00562247185973562 no 80 0.00607491051180969 88 688866 SGTC_3164 9100705 49.47 µM 2.503533836785 0.00569195560813799 no 81 0.00614799611362023 63 17174235 SGTC_1785 bathophenanthroline 24 µM 2.49356910140756 0.0058587049360175 no 82 0.00632329827349124 170 72812 An iron chelator. SGTC_1194 1488-0194 225 µM 2.48856979859705 0.00594398414279449 no 83 0.00641290291570116 144 1391452 SGTC_2910 7948405 25.97 µM 2.46435098355298 0.00637288741834943 no 84 0.00686308132154661 107 2971328 SGTC_2288 7946289 167.31 µM 2.4522402957034 0.00659746274935786 no 85 0.00709849097333043 143 1246052 SGTC_54 0159-0055 9 µM 2.44042803365685 0.00682321619757135 no 86 0.00733493427737449 127 3319099 SGTC_2008 4012253 172 µM 2.43050539020189 0.00701810136390619 no 87 0.00753889088988998 147 603940 SGTC_1442 4112-3290 3 µM 2.42405993486117 0.00714731000510873 no 88 0.00767403611414435 120 704353 SGTC_2593 nobiletin 86.24 µM 2.42023986298838 0.00722487545597817 no 89 0.00775513618833 131 72344 An anti-infammatory. SGTC_3197 9113331 49.47 µM 2.40844074418889 0.00746916051951828 no 90 0.00801041339957289 172 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3284 9108171 64.8615 µM 2.4017294461272 0.00761133139247288 no 91 0.00815888607707741 115 8687505 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.40069976685744 0.00763335346251138 no 92 0.00818187812763538 159 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1190 1486-1332 13 µM 2.3973490223444 0.00770540566626201 no 93 0.00825709251329067 121 4150046 SGTC_2398 5228213 48.84 µM 2.39121598932032 0.00783883816163676 no 94 0.00839633531933782 185 80771 YMR134W ERG29 SGTC_819 1013-0258 27.7 µM 2.37223979017061 0.00826465220453146 no 95 0.00884030598801616 154 5753198 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.3643277760165 0.00844811030082305 no 96 0.00903141177084454 140 94937 An inhibitor of serotonin biosynthesis. SGTC_1389 3405-0187 19 µM 2.36346856409303 0.00846824664963887 no 97 0.00905238129032002 129 799890 SGTC_2809 7964133 12.99 µM 2.36052586651588 0.0085375307518427 no 98 0.00912452280555214 197 1253665 SGTC_521 r062-0005 13.8 µM 2.35821369495494 0.00859231791618396 no 99 0.00918155934095672 111 2832033 SGTC_1025 k007-0731 70 µM 2.35122089776739 0.00875989427787869 no 100 0.00935596080018946 125 6256118 SGTC_1684 st024538 14.6195 µM 2.33584467901998 0.00913848101003116 no 101 0.00974966903383741 147 6732859 SGTC_1070 indatraline 8.81 µM 2.33470753843584 0.00916703972957379 no 102 0.00977935209600277 151 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2257 7960413 200 µM 2.33461868720095 0.00916927447134923 no 103 0.00978167472328956 196 2974689 YIL048W NEO1 SGTC_799 1310-0557 151 µM 2.31935143044286 0.0095604208819613 no 104 0.0101879944460473 152 5354492 SGTC_1619 st003326 88.7 µM 2.30309714776244 0.00999281119112012 no 105 0.0106366888794231 120 2849032 SGTC_1591 genipin 88.4 µM 2.29135544021677 0.0103156875797632 no 106 0.0109714322712697 119 442424 A DNA cross-linking agent. SGTC_1004 4084-0029 199 µM 2.28588793900641 0.0104691131078336 no 107 0.01113040761194 160 716894 YLR208W SEC13 SGTC_2908 7930301 100 µM 2.27687084332394 0.0107264909162266 no 108 0.0113969697348532 187 2223178 SGTC_495 decylubiquinone 155 µM 2.26569347495757 0.0110531639616892 no 109 0.0117350786653754 173 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1514 1189-1591 158 µM 2.23840889086325 0.0118871612354985 no 110 0.0125972013873909 213 767698 YMR146C TIF34 SGTC_2711 st079103 59.1 µM 2.23516884958055 0.0119897354901189 no 111 0.0127031328539536 120 54693780 SGTC_2134 5324836 1.464 µM 2.23465015958014 0.0120062274178745 no 112 0.0127201625333342 130 699272 SGTC_3291 9121177 71.43 µM 2.22406242903164 0.012347192923464 no 113 0.0130721221278639 142 17015612 SGTC_292 k038-0015 474 µM 2.22346519965035 0.0123666734546343 no 114 0.0130922237403956 139 46368540 SGTC_1480 1070-0044 41.2 µM 2.2131414305681 0.0127076477961821 no 115 0.0134439482665954 165 3124987 SGTC_1397 3532-0190 20.1 µM 2.20564444686549 0.0129603300409883 no 116 0.0137044522163609 108 5322280 SGTC_297 0986-0032 24 µM 2.19884394096291 0.0131932838658031 no 117 0.0139445104241339 124 2847425 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.19070195212939 0.0134769417560412 no 118 0.0142366838716163 259 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2742 clothiapine 36.27 µM 2.18760556942245 0.0135861899996908 no 119 0.014349172904122 118 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_194 1486-1323 56.904 µM 2.1876000484265 0.0135863854750458 no 120 0.0143493741589673 154 5178754 SGTC_3282 9108498 15.4605 µM 2.1823746042207 0.0137724882882663 no 121 0.0145409485199624 184 16459645 SGTC_287 k060-0039 29.6 µM 2.17996646650359 0.0138589910152399 no 122 0.014629973670386 145 5861974 SGTC_3090 9117696 49.47 µM 2.17157085660273 0.0141642437037041 no 123 0.0149440236098648 136 7923821 SGTC_1547 harmine 94.2 µM 2.16816415909973 0.0142897487892321 no 124 0.0150730993527251 233 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_811 0416-0114 265 µM 2.1649108118931 0.0144104972608263 no 125 0.0151972580312271 192 6612453 SGTC_3132 9126706 49.47 µM 2.16156514188087 0.0145355875108879 no 126 0.0153258553761704 157 850858 SGTC_2459 5811157 9.22 µM 2.15931895864487 0.014620092748356 no 127 0.0154127151503032 153 2870684 YBR192W RIM2 SGTC_1121 fusaric acid 630.51 nM 2.15703923294881 0.0147062918205434 no 128 0.0155013038370235 197 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_404 fumagillin 50 µM 2.14506262072204 0.0151663579672149 no 129 0.0159739202744126 193 12015870 A methionine aminopeptidase binder. SGTC_911 3456-4043 236 µM 2.14413284449295 0.0152025858081494 no 130 0.0160111220251276 214 914281 SGTC_2614 arthonioic acid 13.39 µM 2.14157903222372 0.0153024754106299 no 131 0.0161136862499379 167 6710684 SGTC_2662 daunorubicin 22.37 µM 2.13530971141601 0.0155500863651285 no 132 0.0163678600934215 163 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1655 st012546 55.1 µM 2.13391033197795 0.0156058228224614 no 133 0.0164250607824022 173 720985 YLR208W SEC13 SGTC_862 0452-0056 10.2 µM 2.13260838381506 0.0156578325034863 no 134 0.0164784325005027 165 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2124 5246320 200 µM 2.12604650825782 0.0159222329356275 no 135 0.0167496936125599 189 579342 SGTC_745 0469-0705 296 µM 2.12247636185793 0.0160676876260758 no 136 0.0168988778287071 216 3486736 SGTC_1618 st003135 44.5 µM 2.12104641562741 0.016126265005658 no 137 0.0169589482877892 153 1270615 SGTC_1332 1480-0653 17.5 µM 2.120356509517 0.0161545922117893 no 138 0.0169879957089212 192 5749438 SGTC_1081 sertraline 6 µM 2.12028349203563 0.0161575927671471 no 139 0.0169910724836981 219 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2264 7948757 110.76 µM 2.11930794529194 0.0161977273818612 no 140 0.017032225315342 185 2971411 SGTC_381 3461-2219 42.7 µM 2.11172385210239 0.0165126646427075 no 141 0.0173550709728914 187 2883159 SGTC_2914 7968218 45.32 µM 2.11165287142093 0.0165156367725989 no 142 0.0173581170523699 126 2977111 SGTC_639 0833-0042 114 µM 2.10438186166118 0.0168225269863659 no 143 0.0176725751708833 229 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1604 st002052 72.4 µM 2.09935167205827 0.0170376810806977 no 144 0.0178929557758471 179 6254834 YHR062C RPP1 SGTC_1425 4048-4433 7.33 µM 2.09354663186299 0.0172888969272064 no 145 0.0181501929533141 216 23734946 SGTC_2786 7743617 45.45 µM 2.08836073219765 0.017515988440004 no 146 0.0183826534290929 173 583674 SGTC_1664 st014217 9.02 µM 2.07136637419455 0.0182781033513023 no 147 0.0191622853980177 191 3982782 SGTC_1616 st002734 56.1 µM 2.07094165509261 0.0182975062524202 no 148 0.0191821244045997 226 4026101 SGTC_903 1134-0042 114 µM 2.05795390854385 0.0188993696620273 no 149 0.0197972790484156 212 701009 SGTC_2263 7948595 193.29 µM 2.05539290590054 0.0190200157005923 no 150 0.0199205350758444 137 2971371 SGTC_1030 k029-0042 36.7 µM 2.05145697507476 0.0192067096205307 no 151 0.0201112327341716 243 6080581 SGTC_3112 9123419 49.47 µM 2.05044453049353 0.0192549842492588 no 152 0.0201605357460214 205 17015854 SGTC_739 1486-1183 203 µM 2.04991010307938 0.0192805079774376 no 153 0.0201866020621125 187 4346692 SGTC_1296 1068-0102 11.9 µM 2.04659555643752 0.0194394504785571 no 154 0.0203489057563154 186 767053 SGTC_117 lucigenin 22.078 µM 2.04206116719622 0.019658690024083 no 155 0.0205727321317889 300 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1265 0819-1001 68.8 µM 2.040857195396 0.0197172540373552 no 156 0.0206325117677687 198 3106768 SGTC_874 0599-0792 117 µM 2.04065138909799 0.0197272797467282 no 157 0.0206427451777636 243 765305 SGTC_2603 homopterocarpin 100 µM 2.03788000423806 0.0198627078660769 no 158 0.020780967388173 254 101795 A weak amylase inhibitor. SGTC_409 arachidonic acid 100 µM 2.03280552250872 0.0201127257776911 no 159 0.0210360874927956 195 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1007 4101-0031 70 µM 2.03092173789849 0.0202062160472764 no 160 0.0211314671335431 203 1146276 SGTC_89 0302-0250 142.109 µM 2.03033593018005 0.020235364080005 no 161 0.021161202180753 232 4203518 YLR208W SEC13 SGTC_231 b-estradiol 524 µM 2.02658041791543 0.0204230751682908 no 162 0.0213526704295244 143 450 A steroid. SGTC_3299 9121982 43.1275 µM 2.02259549835572 0.020623864219707 no 163 0.0215574343529197 224 17594604 YPL160W CDC60 SGTC_2584 androsterone 48.74 µM 2.01910023680829 0.0208013548693069 no 164 0.0217384011316017 390 2754130 A steroid. SGTC_2536 dehydroabietamide 32.04 µM 2.01084450867759 0.0212257247693713 no 165 0.022170941596696 246 3983547 SGTC_654 1124-0271 80.9 µM 2.00286082098745 0.0216430528184004 no 166 0.0225961147043704 252 5403748 SGTC_3355 9151058 44.0485 µM 1.97970947173227 0.0228926257648009 no 167 0.0238680918278821 211 17015728 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.97919377851443 0.0229211377448047 no 168 0.0238970965654376 266 23665772 A membrane-active detergent. SGTC_3234 9132280 49.47 µM 1.97897528423946 0.0229332270165875 no 169 0.0239093945266572 236 17612295 SGTC_197 4544-0043 41.561 µM 1.97875974363056 0.0229451581245698 no 170 0.0239215314519858 283 896523 SGTC_948 3448-0295 75.3 µM 1.97503446518326 0.023152195984719 no 171 0.024132118468253 255 678569 SGTC_1882 5615643 20 µM 1.97347598293798 0.0232392764146878 no 172 0.0242206791177313 192 2253075 SGTC_796 1234-0020 70.7 µM 1.95671999632093 0.024193060447457 no 173 0.0251901987956021 236 46495034 SGTC_332 4112-0506 40.9 µM 1.9507380946009 0.0245414319817819 no 174 0.0255441046342205 209 2790355 SGTC_1399 3562-5772 25 µM 1.94279329651638 0.025010618113639 no 175 0.0260205690928675 187 23847490 SGTC_2082 5219693 150 µM 1.93745422646871 0.0253301274688832 no 176 0.0263449217634415 257 2834649 SGTC_1484 3473-2379 286 µM 1.93369872412342 0.0255569131169405 no 177 0.0265750904064088 250 671917 SGTC_3354 9151612 71.43 µM 1.92944520281207 0.0258158237245645 no 178 0.0268378083143671 234 27261949 SGTC_628 1636-0253 16 µM 1.92582144382821 0.0260381290764761 no 179 0.0270633364672272 277 4456143 SGTC_2064 5220758 200 µM 1.9201568602357 0.0263888385074615 no 180 0.0274190444424315 289 788518 SGTC_1491 4138-0063 26.5 µM 1.91075317982052 0.026979758865567 no 181 0.0280181535667124 189 23883227 SGTC_4 0960-0234 25.671 µM 1.90785482674211 0.0271641008383778 no 182 0.0282049911040474 222 6821112 SGTC_485 niflumic acid 177 µM 1.90730870589715 0.0271989527863556 no 183 0.0282403117505951 211 4488 A COX2 inhibitor. SGTC_1671 st016596 74.5 µM 1.90627687341674 0.0272649033602885 no 184 0.0283071465450538 266 2829167 SGTC_1298 1079-1278 263 µM 1.90217108012426 0.0275286519542327 no 185 0.0285743961543596 253 2840950 SGTC_1698 5-fluorocytosine 1.055 µM 1.90153167770012 0.0275699167819707 no 186 0.0286162036734348 208 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_706 4262-0057 46.9 µM 1.89275556954219 0.0281415261031792 no 187 0.0291951913363139 264 883298 SGTC_2425 5628681 7.85 µM 1.88476430930998 0.0286705663307178 no 188 0.0297308327840093 291 5714958 SGTC_3093 9117344 49.47 µM 1.8740896981192 0.0293901291615022 no 189 0.0304590315005082 236 24824913 SGTC_2266 7929956 200 µM 1.87124824820678 0.0295841751322558 no 190 0.0306553400202602 275 2967153 SGTC_2315 7733312 200 µM 1.86891874778634 0.0297440516247639 no 191 0.030817059786359 241 726316 SGTC_1663 st014140 55.4 µM 1.86450216472068 0.0300491352067836 no 192 0.0311256089322027 279 4207120 SGTC_2213 7173844 200 µM 1.85873744194954 0.030451243122483 no 193 0.0315321817628229 246 892728 SGTC_2931 9014674 55.67 µM 1.84928506419692 0.0311202183025111 no 194 0.0322083306371982 271 2996810 SGTC_836 0330-0104 1.35 µM 1.84768919567143 0.0312343539382984 no 195 0.0323236589304842 262 46494820 SGTC_93 0109-0045 59.227 µM 1.84414513389184 0.0314890617777217 no 196 0.0325809958972546 367 88733 SGTC_3094 9117742 49.47 µM 1.84173592452256 0.0316631874695804 no 197 0.032756893330477 309 17149698 SGTC_1628 st004252 77.7 µM 1.83871483814104 0.031882660272879 no 198 0.032978569899205 284 692968 SGTC_1854 st056233 32.9 µM 1.83815157631976 0.0319237181995859 no 199 0.033020036476495 250 5393174 SGTC_1460 k062-0059 9.15 µM 1.8309860820863 0.0324498553117671 no 200 0.0335513102396565 252 1373085 SGTC_2827 7993847 71.43 µM 1.82975890535921 0.0325406761615984 no 201 0.033642999141723 225 2985692 SGTC_349 k015-0014 24 µM 1.82148080921066 0.0331588131158807 no 202 0.0342669006292515 265 2196908 SGTC_2280 7785178 200 µM 1.81249058062758 0.0338410500026314 no 203 0.0349552140330454 244 2954328 SGTC_2642 cholecalciferol 100 µM 1.80928217819684 0.0340873031181282 no 204 0.0352035881416493 238 9821465 A vitamin D precursor, similar to steriods. SGTC_1728 st035614 33.7865 µM 1.80421808273496 0.0344789820822683 no 205 0.0355985628305449 362 15945546 SGTC_430 0958-0115 16.4 µM 1.79740540222755 0.035011729752356 no 206 0.0361356418714623 298 6833180 SGTC_541 4513-1321 94 µM 1.79697512013225 0.035045603136946 no 207 0.0361697848205471 289 747515 SGTC_3084 9116877 49.47 µM 1.79163331291264 0.0354683735574724 no 208 0.036595861615698 207 27241325 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.78105080215758 0.0363182615603716 no 209 0.0374520759248286 287 390807 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.78090810592763 0.036329834496961 no 210 0.0374637320949677 267 279621 SGTC_3283 9109332 35.8195 µM 1.77828033299908 0.0365434920408727 no 211 0.0376789123922035 229 17027281 SGTC_2600 tangeritin 87.95 µM 1.77568280486783 0.036755699751212 no 212 0.0378926065616775 278 68077 A bioactive flavone. SGTC_2362 9071156 126 µM 1.77344923972967 0.0369389780399219 no 213 0.0380771479811921 296 653133 SGTC_2705 st078069 42.8 µM 1.76872289826115 0.0373292680993481 no 214 0.0384700645247724 257 1530061 SGTC_2092 5303694 80.6725 µM 1.76796886756416 0.0373918446378066 no 215 0.0385330542118459 326 1963699 SGTC_1656 st012921 11 µM 1.76362564305309 0.0377539562362151 no 216 0.0388975137300949 255 6732821 SGTC_3117 9124945 49.47 µM 1.75908896517396 0.0381352479743082 no 217 0.0392811994469646 229 17592065 SGTC_2808 7946468 45.46 µM 1.75763758019457 0.0382578928038378 no 218 0.0394045973957414 346 2970879 SGTC_2022 5136654 200 µM 1.75497413451007 0.0384837956724706 no 219 0.0396318660653783 310 1713771 SGTC_2236 dapsone 200 µM 1.75382675549334 0.0385814462751762 no 220 0.0397300985169067 299 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1440 4100-1550 40 µM 1.75272152406548 0.0386757006331568 no 221 0.0398249096174497 227 742806 SGTC_578 3460-0051 92 µM 1.75090144400822 0.0388313262126458 no 222 0.0399814440154195 330 2876744 SGTC_871 0574-0004 149 µM 1.74980105700116 0.0389256617227874 no 223 0.0400763241204624 342 9551173 SGTC_823 0417-1665 178 µM 1.74469386943579 0.0393659438596606 no 224 0.0405190855105426 316 3429856 SGTC_1319 1306-0155 43.7 µM 1.74146358158219 0.0396465075062671 no 225 0.0408011757907739 356 3122360 SGTC_721 1187-1332 279 µM 1.72852134586341 0.0407869436049774 no 226 0.041947398713244 210 25730 SGTC_2859 9028643 45.46 µM 1.72752913645261 0.0408754619587218 no 227 0.0420363385469925 270 17151580 SGTC_1041 0206-0046 107 µM 1.72370235971889 0.0412183223458922 no 228 0.0423807944097427 303 50494 SGTC_3116 9124943 49.47 µM 1.71076467636363 0.0423947756646369 no 229 0.0435622814212626 308 41905195 YPL160W CDC60 SGTC_2478 5763493 32.33 µM 1.7090212475171 0.0425553661169747 no 230 0.0437235068871172 310 1365576 YLR208W SEC13 SGTC_67 0335-0847 266 µM 1.70746958356924 0.0426987061405084 no 231 0.0438674032888446 494 4552207 YOR254C SEC63 SGTC_3129 9127257 49.47 µM 1.69893733778026 0.0434938885064425 no 232 0.0446654954696852 297 837894 SGTC_140 0062-0056 502.533 µM 1.69772778300074 0.0436075769961858 no 233 0.0447795757551387 358 3758964 SGTC_342 k048-0088 23.3 µM 1.69670072712718 0.043704300211957 no 234 0.0448766275737877 318 6820570 SGTC_72 0744-0168 198.391 µM 1.69346596239783 0.0440100665214526 no 235 0.0451834042329803 324 677577 SGTC_1208 2323-2347 50.3 µM 1.6881827994576 0.0445131651674936 no 236 0.045688071999226 304 5412760 SGTC_1773 st048542 73.5835 µM 1.68354971400687 0.0449581628441808 no 237 0.0461343619817532 369 3237138 SGTC_2523 spermine 47.74 µM 1.67800209614106 0.0454957027848683 no 238 0.0466733449042666 314 1103 A DNA binding polyamine. SGTC_2093 5331342 194.4 µM 1.67733841300638 0.0455603554789457 no 239 0.0467381625312244 337 33839 SGTC_3307 9126885 69.2785 µM 1.67491610628291 0.0457969515641784 no 240 0.0469753465215817 368 24824909 SGTC_3105 9121040 49.47 µM 1.67472419600869 0.045815738321243 no 241 0.046994178909351 149 41448907 SGTC_686 1319-0111 510 µM 1.67248868702994 0.0460350365760764 no 242 0.0472139984177729 349 4562600 SGTC_1837 st055472 66.5 µM 1.67110194423566 0.0461714960793408 no 243 0.047350771714221 338 676091 SGTC_2311 7694451 200 µM 1.66940184535703 0.0463392337873374 no 244 0.0475188840932486 350 2163142 SGTC_784 4579-0127 173 µM 1.66887291370171 0.0463915197074308 no 245 0.0475712843200324 333 1948547 SGTC_2991 9074669 71.4286 µM 1.66885187626326 0.0463936002779429 no 246 0.0475733694146913 415 17333109 SGTC_1983 st071813 46.9 µM 1.66820603491246 0.0464575094572498 no 247 0.0476374166553648 324 11838595 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.66553030658951 0.0467230391651767 no 248 0.0479035012120479 318 16623 A steroid. SGTC_2736 butenafine 14.65 µM 1.66025544710316 0.0472500628548821 no 249 0.0484315372175757 389 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1303 1160-0052 261 µM 1.65027983343714 0.0482597689714125 no 250 0.0494428574942935 344 3562476 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.64784507448953 0.0485088114696131 no 251 0.0496922334047897 325 2346 DNA damaging agent; causes G2/M arrest. SGTC_3335 9143315 29.6265 µM 1.63949983928942 0.0493702208371294 no 252 0.0505546020588061 331 4899691 SGTC_3073 9114972 49.47 µM 1.63922007235838 0.049399309061989 no 253 0.0505837174752128 311 41905075 SGTC_3264 9137442 49.47 µM 1.63910686621101 0.0494110833394419 no 254 0.0505955026633197 300 17015726 SGTC_368 fentichlor 4.58 µM 1.63217455057923 0.0501363746339664 no 255 0.0513213601819922 307 7329 A pesticide. SGTC_1763 st044482 94.5 µM 1.63086785366818 0.0502740333873887 no 256 0.051459103048183 367 88505 SGTC_420 mitomycin C 81.9 mM 1.6244467481782 0.0509548709146179 no 257 0.052140248406745 380 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_873 0591-4978 488 µM 1.62313820923578 0.0510945130529399 no 258 0.0522799316148353 375 3305145 SGTC_2207 7258803 200 µM 1.61011114924327 0.0525013760067534 no 259 0.0536867967640056 297 3666799 SGTC_1612 st002233 45.4 µM 1.60817227398216 0.0527133697885518 no 260 0.0538987268661264 365 1035021 SGTC_2646 retinol 96.75 µM 1.59804592726682 0.0538316284531323 no 261 0.055016378125396 358 445354 A vitamin A analog and teratogen. SGTC_1724 st037281 8.293 µM 1.59334690748305 0.0543568854871771 no 262 0.0555411945691352 401 574124 YDL195W SEC31 SGTC_1734 st037168 69.4 µM 1.59135061757069 0.0545812545515456 no 263 0.055765345612199 381 708907 SGTC_658 3253-0951 102 µM 1.58783906449896 0.0549777051546552 no 264 0.0561613677293606 495 1184878 SGTC_69 0096-0274 206.684 µM 1.58758097877526 0.0550069322912396 no 265 0.056190561101639 450 6741392 SGTC_3217 9129673 49.47 µM 1.58040586520953 0.0558244100829756 no 266 0.0570069746220618 385 17248312 SGTC_551 k048-0028 34.9 µM 1.57844959041927 0.0560489481107068 no 267 0.0572311801256414 397 6836383 SGTC_757 1066-0008 322 µM 1.57192516888167 0.0568029630492334 no 268 0.0579839533567128 409 6842497 SGTC_502 l-744,832 89.3 µM 1.5702824895436 0.0569940577600734 no 269 0.0581747030269213 390 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2630 antimycin a 100 µM 1.570257648878 0.0569969513824402 no 270 0.0581775913309074 430 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2575 plumbagin 510 nM 1.56748011112931 0.0573212294578574 no 271 0.058501255760367 397 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2133 5320837 200 µM 1.56482596290639 0.0576324565233141 no 272 0.058811861157725 382 2841355 SGTC_1949 st076024 69.1 µM 1.56231404749305 0.0579282278245289 no 273 0.0591070121666526 408 2921930 SGTC_353 1988-1175 58.3 µM 1.55635021874396 0.0586352316932439 no 274 0.0598124179376459 360 2788357 SGTC_2685 mycophenolic acid 18.85 µM 1.55306556415859 0.0590275058593784 no 275 0.060203735952378 328 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_415 dibenzyl ketone 100 µM 1.5506323830018 0.0593194168143126 no 276 0.0604949035371181 376 7593 SGTC_2994 9053520 71.4286 µM 1.5492086582716 0.0594907465475709 no 277 0.060665784388983 394 4647384 SGTC_1209 2323-2347 50.3 µM 1.5483842231489 0.0595901355056867 no 278 0.0607649087021615 366 5412760 SGTC_3119 9125183 49.47 µM 1.54687253999565 0.0597727129676951 no 279 0.0609469919113554 261 22695334 SGTC_747 3448-8087 38.7 µM 1.54525832289567 0.0599681577713894 no 280 0.0611418960437424 437 5168703 SGTC_2839 9003951 25.97 µM 1.53049603118633 0.0617788291230004 no 281 0.0629469975526557 368 2990634 SGTC_2793 7325131 81.82 µM 1.52973205843134 0.0618736833105296 no 282 0.0630415324577022 368 4176441 SGTC_153 4077-0274 519.67 µM 1.52714895647004 0.0621952410796739 no 283 0.0633619877945867 375 3121976 SGTC_2065 5221596 34.26 µM 1.52464540575816 0.0625081384324321 no 284 0.0636737828187275 401 788581 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.52044463930791 0.063035911806765 no 285 0.0641996312611481 386 689007 SGTC_3009 9080819 71.4286 µM 1.51349181545794 0.0639170650434207 no 286 0.065077389280828 394 17027216 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.51183300095498 0.0641287005440737 no 287 0.065288175893049 413 4213774 SGTC_3010 9080089 71.4286 µM 1.51174701870751 0.0641396851959811 no 288 0.0652991161337695 384 17027233 SGTC_2176 5809774 33.9695 µM 1.51144847787107 0.0641778366017627 no 289 0.0653371130241478 410 2870539 SGTC_1850 st056238 17 µM 1.51007721020057 0.0643533015379446 no 290 0.0655118619579347 462 5393177 SGTC_818 4072-2707 53.5 µM 1.50468271583785 0.065047191223717 no 291 0.0662028344284349 365 882871 SGTC_626 0214-0009 33 µM 1.49964048297107 0.0657010070987168 no 292 0.0668537776066535 424 3437874 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.49904377799956 0.0657787165348147 no 293 0.0669311376861962 424 5282309 SGTC_2496 diffractaic acid 79.83 µM 1.49385286986598 0.0664577420926605 no 294 0.0676070396243233 463 94870 An apoptosis inducer which activates caspases. SGTC_2951 9072950 58.06 µM 1.49192653731172 0.0667111028271308 no 295 0.0678592024636051 450 16488155 SGTC_2976 9009005 19.48 µM 1.49168602109535 0.0667427891224708 no 296 0.0678907377145396 415 2993148 SGTC_177 1327-0068 8.361 µM 1.48990838147686 0.0669773417030135 no 297 0.0681241637322674 450 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_889 0919-1524 82.7 µM 1.48963361083509 0.0670136534346375 no 298 0.0681602997243727 409 3905452 SGTC_1687 st020778 55.3625 µM 1.48944786298932 0.0670382091718138 no 299 0.0681847364158328 597 4259299 SGTC_2137 5261020 140 µM 1.48892744132396 0.0671070456205039 no 300 0.0682532382777914 421 763655 SGTC_682 0kpi-0099 17 µM 1.48762233510963 0.0672799131230494 no 301 0.068425259901527 483 1714895 YML126C ERG13 SGTC_1669 st015249 58.4 µM 1.48601337071161 0.067493501659614 no 302 0.0686377921965693 390 722793 SGTC_2240 6690706 185.951 µM 1.48507102407012 0.0676188404074045 no 303 0.0687625054204744 363 805876 SGTC_1848 st056003 16.4 µM 1.48442559188125 0.0677047911551069 no 304 0.0688480247880258 437 146492 SGTC_3343 9148379 18.9835 µM 1.48281542548966 0.0679195812744283 no 305 0.069061728277515 413 1955036 SGTC_3315 9136395 68.55 µM 1.48085675607595 0.0681815692897444 no 306 0.0693223742890513 438 16876844 SGTC_362 0310-0100 9.03 µM 1.48060482315703 0.0682153239137225 no 307 0.0693559546866398 461 790235 SGTC_2771 fluoxetine 41.05 µM 1.48038765262908 0.0682444313323299 no 308 0.0693849116238305 395 3386 A selective serotonin reuptake inhibitor. SGTC_924 2046-0044 21.3 µM 1.48019571409872 0.0682701648789761 no 309 0.0694105119451016 426 3623589 SGTC_1768 st044301 37.178 µM 1.47868190146103 0.0684733869991097 no 310 0.0696126758260862 438 3931349 SGTC_630 4356-0227 183 µM 1.46707677810468 0.0700468543764199 no 311 0.0711775852140964 419 779312 SGTC_2377 9073351 62.6 µM 1.46673635105885 0.0700934272663579 no 312 0.0712238950734943 429 7337946 YHR072W ERG7 SGTC_1564 D-Arginine 115 µM 1.46621092282453 0.0701653564124397 no 313 0.07129541689726 449 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_548 1436-0017 110 µM 1.46468239719561 0.0703749286469892 no 314 0.0715037948539821 539 9677137 SGTC_1286 0929-0070 131 µM 1.4575929180131 0.0713532470209451 no 315 0.0724763914276386 469 1420408 SGTC_440 fluspirilene 35.1 µM 1.45663543332544 0.071486172161966 no 316 0.0726085206469804 458 3396 An atypical antipsychotic. SGTC_1231 0242-0792 125 µM 1.45305997036393 0.0719842246776861 no 317 0.0731035519951719 447 3707635 SGTC_1647 st011722 22.4 µM 1.45035511250524 0.0723627686133855 no 318 0.0734797588183294 417 2854783 SGTC_2583 asiatic acid 100 µM 1.44878337457701 0.0725834323970651 no 319 0.0736990440545814 418 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_992 3909-8734 162 µM 1.44763134657432 0.0727454981567546 no 320 0.073860089790185 444 4288319 SGTC_2776 terbinafine 19.92 µM 1.44379698278364 0.0732869075558003 no 321 0.0743980454909158 455 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1971 st069429 63.5 µM 1.44375699758963 0.0732925696318685 no 322 0.0744036710745727 417 1246522 YGL099W LSG1 SGTC_737 1950-0117 57.9 µM 1.44134015560859 0.0736354266564888 no 323 0.0747443040340381 445 5393513 SGTC_1979 st071809 45.3 µM 1.4405567361948 0.0737468265266372 no 324 0.0748549752165036 442 4976333 SGTC_708 3448-5400 146 µM 1.43999847901327 0.0738262875813158 no 325 0.0749339146932932 480 3462195 SGTC_2887 9044784 58.44 µM 1.43988390636179 0.0738426036811664 no 326 0.0749501235091136 460 6465546 SGTC_1418 3966-3099 2.4 µM 1.4370940406371 0.0742407549028345 no 327 0.0753456371577456 480 740335 SGTC_335 4077-0256 27.6 µM 1.43647300761006 0.074329607333958 no 328 0.0754338958600336 521 3121989 SGTC_1092 toremifene 6.32 µM 1.43152714614848 0.0750401223302438 no 329 0.0761395963206496 512 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.42964086197641 0.075312463390441 no 330 0.0764100607126559 470 688798 SGTC_178 4092-0806 87.505 µM 1.42854652396865 0.0754708085247942 no 331 0.0765673068021931 575 2169044 SGTC_2863 9028737 58.44 µM 1.42652893275181 0.0757634085934609 no 332 0.0768578607517515 387 6460917 SGTC_268 camptothecin 39.6153 µM 1.42485209122203 0.0760072484547933 no 333 0.077099980427279 583 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1968 st069590 43.6 µM 1.42065668469006 0.0766199456339604 no 334 0.0777082953522892 457 6384066 SGTC_1513 0337-0559 19 µM 1.42054395565968 0.076636460251844 no 335 0.0777246906703538 407 775073 SGTC_2071 5230951 39.92 µM 1.42045770174388 0.076649098136925 no 336 0.0777372372190112 490 1799272 SGTC_2308 7584454 197.62 µM 1.41778014716687 0.0770422009853637 no 337 0.0781274810277766 533 893577 SGTC_2802 7925815 54.55 µM 1.41431396150758 0.0775533592547552 no 338 0.0786348697268303 507 1262923 SGTC_3052 9092717 49.47 µM 1.40988428303902 0.0782103470671915 no 339 0.0792869271261874 466 25237534 SGTC_3017 9080681 49.47 µM 1.40972823178247 0.0782335685485882 no 340 0.079309972594485 451 16451914 SGTC_857 0438-0306 1.35 µM 1.409358026499 0.0782886785128903 no 341 0.0793646643637679 470 4686136 SGTC_487 nimodipine 119 µM 1.40843339146164 0.0784264512814753 no 342 0.0795013887401259 339 4497 L-type voltage-gated calcium channels inhibitor SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.40689436941239 0.0786561766407921 no 343 0.0797293567301015 458 75037 A free radical scavenger. SGTC_2156 5649887 115 µM 1.40647556724376 0.0787187782092618 no 344 0.0797914774030389 543 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.40534651992243 0.0788877336511788 no 345 0.079959130687697 507 6708561 SGTC_679 0422-0091 41.4 µM 1.40264185298508 0.0792935886296849 no 346 0.0803618323437409 518 627384 YHR062C RPP1 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.39958366207258 0.079754394326603 no 347 0.0808190146255659 465 6708760 SGTC_1252 0493-0875 34.8 µM 1.39498979634938 0.0804503970103278 no 348 0.081509458271802 471 3960963 SGTC_2694 st077685 81.9 µM 1.39264953253748 0.0808067229176037 no 349 0.0818628983622437 480 2838096 SGTC_1048 3161-0300 24.5 µM 1.39138716534468 0.0809994235942709 no 350 0.0820540272391969 523 2165101 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.38834530735998 0.0814651886156251 no 351 0.0825159610136284 570 91467 include heat shock SGTC_3077 9117319 49.47 µM 1.38782505379112 0.0815450509810234 no 352 0.0825951619061629 416 17154678 SGTC_1634 st006576 41 µM 1.3855372601101 0.0818969431865574 no 353 0.0829441237291835 480 3915356 SGTC_1705 st027868 56.3335 µM 1.3836109489313 0.0821941211307666 no 354 0.0832388069730421 463 292948 SGTC_180 1486-1293 102.781 µM 1.38284155015777 0.0823130453815553 no 355 0.0833567278018372 480 4140536 SGTC_941 3237-0776 460 µM 1.3827549128982 0.0823264448221713 no 356 0.0833700140026612 463 760008 SGTC_1019 4262-0212 3.4 µM 1.38258705640175 0.0823524104184122 no 357 0.0833957600565564 580 4677213 SGTC_956 1185-0240 191 µM 1.37268836769719 0.0838945589587796 no 358 0.0849246234725602 469 1416193 SGTC_2774 tamoxifen 10.92 µM 1.37187040470166 0.0840229557126664 no 359 0.0850518925076485 479 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2549 cedrol 20.94 µM 1.36548712997439 0.0850300196181004 no 360 0.0860499977161768 451 6708665 A sedative which affects the nervous system. SGTC_2330 7979373 200 µM 1.36259432747764 0.0854893733628367 no 361 0.0865051987916036 517 1863007 SGTC_2184 6075246 200 µM 1.35936868625976 0.0860037679300846 no 362 0.0870148943188183 508 2267320 SGTC_1285 0929-0069 65.5 µM 1.35800416349678 0.086222064769678 no 363 0.0872311815188219 507 1206237 SGTC_1972 st070201 17.4 µM 1.35723534281982 0.0863452433745715 no 364 0.0873532220903401 519 2829099 SGTC_942 3253-1115 227 µM 1.35657972483014 0.086450388833853 no 365 0.0874573938154835 517 46497897 SGTC_1306 1185-0270 9.02 µM 1.35609299098923 0.0865285112072354 no 366 0.0875347913373578 557 1548076 SGTC_2706 st078239 82.5 µM 1.35576047506294 0.086581911435428 no 367 0.0875876954233379 494 15434492 SGTC_413 propylparaben 100 µM 1.35481661581689 0.0867336242383377 no 368 0.0877379956836064 501 7175 A pharmaceutical preservative. SGTC_1280 0880-0253 10.1 µM 1.346973176076 0.0880020453025587 no 369 0.0889944359685566 530 6836607 SGTC_1574 spiramycin 23.7 µM 1.3409371187527 0.0889875607927875 no 370 0.0899704347016065 530 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1161 k007-0610 110 µM 1.33892117400869 0.0893185302793889 no 371 0.0902981678688888 640 5843850 SGTC_2864 9034755 47.6 µM 1.33756404692011 0.0895418530068159 no 372 0.0905192955317582 515 4930451 SGTC_3351 9150312 21.596 µM 1.33725736637783 0.0895923764479278 no 373 0.0905693211079096 528 4904905 SGTC_2866 9034245 58.44 µM 1.33347392116484 0.0902174170459533 no 374 0.0911881640661645 452 6462273 SGTC_3007 9078383 71.4286 µM 1.3330801753019 0.0902826510939805 no 375 0.0912527472013466 513 6496995 SGTC_1271 0832-2808 169 µM 1.32822237656355 0.0910903537456386 no 376 0.092052327125738 543 3663794 SGTC_1103 duloxetine 36.1 µM 1.32822193556184 0.091090427313162 no 377 0.0920523999481063 592 60835 A selective serotonin reuptake inhibitor. SGTC_1055 3448-0672 86 µM 1.32730060805132 0.0912442186021676 no 378 0.0922046314000031 517 748378 SGTC_3158 9100007 49.47 µM 1.32729446954995 0.0912452439080418 no 379 0.0922056462925319 449 19297233 SGTC_637 1181-0519 7.26 µM 1.32718623642668 0.0912633233486168 no 380 0.0922235420816336 646 6252091 YGR060W ERG25 SGTC_477 mead ethanolamide 10 µM 1.32072899792262 0.0923467631268315 no 381 0.093295870781838 346 16061185 SGTC_2867 9039098 71.43 µM 1.31914490852356 0.0926140006462584 no 382 0.0935603360083103 546 6463460 SGTC_2034 5197015 53.07 µM 1.31902529042234 0.0926342035486626 no 383 0.0935803288220404 543 780676 SGTC_1421 4029-0249 71.4 µM 1.31466924034931 0.0933721412816692 no 384 0.0943105443002254 572 2894095 SGTC_605 1315-0399 119 µM 1.31407682279006 0.09347283444249 no 385 0.0944101764565546 584 24020461 SGTC_92 0063-0024 660.874 µM 1.308839328234 0.0943665419444479 no 386 0.0952943909497323 602 3594437 SGTC_2543 pimpinellin 60.67 µM 1.30846584611645 0.0944305114831313 no 387 0.0953576757893124 505 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1989 st071868 50.2 µM 1.30389601418847 0.0952158171850061 no 388 0.0961345197256229 557 16414057 SGTC_480 am 92016 50 µM 1.30368395433409 0.0952523751544779 no 389 0.0961706812565927 495 2129 K+ channel blocker. SGTC_1087 pterostilbene 9.05 µM 1.30267154897173 0.0954270508108084 no 390 0.0963434596301908 577 5281727 Similar to reservatol, lowers cholesterol. SGTC_3314 9135860 59.4275 µM 1.29819307540648 0.096202574466182 no 391 0.0971104985096497 560 25252478 SGTC_536 3852-0578 10.6 µM 1.29789499694479 0.0962543557728885 no 392 0.097161709750484 554 2869208 SGTC_2347 9049783 174.81 µM 1.29709356552771 0.0963936796443287 no 393 0.097299497600059 600 6467988 YPL169C MEX67 SGTC_1042 0350-0096 82 µM 1.29645785972295 0.0965042984993899 no 394 0.0974088946297858 539 3122515 SGTC_1412 3909-8563 178 µM 1.29469096489955 0.0968122448134048 no 395 0.0977134290057698 609 23767530 SGTC_553 k007-0256 45.7 µM 1.28987257370304 0.0976556923292646 no 396 0.0985474523594333 566 6287000 SGTC_1487 3970-0795 2.82 µM 1.28683073645875 0.0981909255222534 no 397 0.0990766456195314 583 3765103 SGTC_2565 isoliquiritigenin 100 µM 1.28541883770848 0.0984400882239058 no 398 0.0993229809515586 446 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1557 sumaresinolic acid 42.3 µM 1.28463415825079 0.0985787633338684 no 399 0.0994600781611796 533 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1952 st077036 64.1 µM 1.28323646958729 0.0988261286910875 no 400 0.099704621309978 570 2937007 SGTC_2487 5918373 44.05 µM 1.27985440817819 0.0994265704001671 no 401 0.100298172287795 574 2876279 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.27895595844907 0.0995865260222814 no 402 0.100456282673304 482 77254 SGTC_43 0570-0105 72.5 µM 1.27851621761017 0.0996648838526703 no 403 0.100533735110269 660 1114046 YDL195W SEC31 SGTC_1735 st034310 56.75 µM 1.27785602023802 0.0997826096100301 no 404 0.100650098788047 565 871153 SGTC_244 nsc-207895 1.295 µM 1.27677123022597 0.0999762688541894 no 405 0.100841512699524 447 42640 SGTC_432 NS 1619 61.3 µM 1.27673173290568 0.0999833251831065 no 406 0.100848487105246 516 4552 A K+/calcium channel activator. SGTC_1754 st042065 16.137 µM 1.27404830145538 0.100463581312146 no 407 0.101323149333772 708 1126236 YIL048W NEO1 SGTC_2419 paclitaxel 166.5 µM 1.27279226069452 0.100688953472076 no 408 0.101545884105898 625 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1471 k673-0312 37 µM 1.27091884481698 0.101025786449426 no 409 0.101878760755443 541 24099884 SGTC_290 2043-6722 48.1 µM 1.27077046700628 0.101052499270392 no 410 0.101905159070741 571 773758 YLR208W SEC13 SGTC_2407 paclitaxel 400 µM 1.2701594352572 0.101162559069601 no 411 0.102013921918208 589 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3321 9137793 26.8275 µM 1.26990946631154 0.101207608956343 no 412 0.102058440399286 595 4904192 SGTC_2155 5570423 76 µM 1.2679499200794 0.101561268731486 no 413 0.102407917658347 554 797402 SGTC_1565 sinapyl alcohol 95.1 µM 1.26492085458609 0.102109725302488 no 414 0.102949850364525 542 5280507 A phenol propionate derived from cinnamic acid. SGTC_1838 st055369 84.5 µM 1.26073287105948 0.102871565598415 no 415 0.103702553341581 527 676036 SGTC_895 0964-0006 13.7 µM 1.26032619205773 0.102945764394794 no 416 0.103775857570582 566 6738897 SGTC_2733 amorolfine 100 µM 1.25859604836394 0.103261864571429 no 417 0.10408813754124 450 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_860 0443-0016 25.1 µM 1.25275561492692 0.104334125450964 no 418 0.105147329592968 577 5337942 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.25235288212545 0.104408360540452 no 419 0.105220653647186 549 521171 SGTC_109 0132-0036 33.701 µM 1.25079907196914 0.104695130555328 no 420 0.105503896784019 435 67274 A color developer. SGTC_2301 7769476 200 µM 1.24773487235382 0.105262327758232 no 421 0.106064083068692 517 977820 SGTC_1474 0330-0125 5.35 µM 1.24687646866083 0.105421620089926 no 422 0.106221398083605 588 X1474 SGTC_115 0527-0192 112.043 µM 1.24676312992677 0.105442665165836 no 423 0.106242181650938 681 4233931 SGTC_3254 9136651 49.47 µM 1.24535045709439 0.105705229507272 no 424 0.106501477986698 613 16454030 SGTC_2033 5192550 145 µM 1.23895991292485 0.106898904623094 no 425 0.107680172007087 565 182073 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.23851939430714 0.106981544934096 no 426 0.107761767678637 577 115019 SGTC_2282 7944268 200 µM 1.23762007642063 0.107150398018328 no 427 0.107928483337882 616 2970414 SGTC_2271 7849410 118.62 µM 1.23748292112809 0.107176166743565 no 428 0.107953925517643 584 972430 SGTC_1675 st018485 24.5 µM 1.23659355291 0.107343369615109 no 429 0.108119007304281 590 3323024 SGTC_1140 3229-1848 2.98 µM 1.23581753490827 0.107489415987221 no 430 0.108263197772949 602 2849525 SGTC_1635 st007035 42.4 µM 1.23417762851312 0.107798516870294 no 431 0.108568360893554 779 3716403 SGTC_77 0828-0286 12.516 µM 1.23336654013201 0.10795163283513 no 432 0.108719521324468 602 745345 SGTC_2522 biochanin a 4.94 µM 1.2327509290509 0.10806795140859 no 433 0.108834352149187 547 5280373 A possible chelator. SGTC_3179 9107801 49.47 µM 1.23060297219979 0.108474510518213 no 434 0.109235696535845 584 4818259 SGTC_3209 9113616 49.47 µM 1.22770799228977 0.10902420336067 no 435 0.109778302556364 643 16649353 SGTC_475 α-linolenic acid 10 µM 1.2271633299892 0.109127846101735 no 436 0.109880604461168 620 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2186 6124449 200 µM 1.22703570326279 0.109152142181792 no 437 0.10990458600815 590 3834182 YLR033W RSC58 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.22471808017483 0.109594020456964 no 438 0.110340729766903 699 368090 SGTC_1445 4239-0156 97.7 µM 1.22438764760214 0.109657125238155 no 439 0.11040301343445 697 4008346 SGTC_969 1313-0238 134 µM 1.2234002457213 0.10984585100815 no 440 0.110589280302775 645 5212874 SGTC_3280 9140961 49.47 µM 1.22243817740019 0.110029958793857 no 441 0.110770984714415 569 4901226 SGTC_1931 st074438 57.1 µM 1.22208373195724 0.110097843606106 no 442 0.110837982192909 570 2787313 SGTC_282 k297-0036 65.7 µM 1.22102034433798 0.110301688144882 no 443 0.111039158516927 551 5061378 SGTC_321 4534-3890 65.3 µM 1.21976013482214 0.110543612431843 no 444 0.111277908903683 601 699746 SGTC_1326 1431-2094 10.8 µM 1.21949024387198 0.110595473211594 no 445 0.111329088280592 624 616278 SGTC_1334 1486-0610 236 µM 1.21589011100573 0.111288923534468 no 446 0.112013392835643 613 3742339 SGTC_1775 st081588 35.1725 µM 1.21186750866904 0.112067424741473 no 447 0.112781550668191 652 1426443 YGL099W LSG1 SGTC_2259 7964009 200 µM 1.20942423179655 0.112542172653808 no 448 0.113249951903441 569 313134 SGTC_1469 k284-2957 126 µM 1.20829635250544 0.112761812439555 no 449 0.113466645488056 590 23884841 SGTC_20 0481-0013 4.944 µM 1.20537594650572 0.113331945205452 no 450 0.11402910143233 600 182045 SGTC_489 paxilline 115 µM 1.20336125013913 0.113726458538467 no 451 0.114418278123388 569 105008 A toxic potassium channel blocker. SGTC_2993 9054257 71.4286 µM 1.20004163188557 0.114378632236981 no 452 0.115061586092027 634 6470217 YGL055W OLE1 SGTC_813 k007-0158 173 µM 1.1980197603566 0.114777152432122 no 453 0.115454662139108 692 6523916 SGTC_1370 2001-0092 44.6 µM 1.19735018706558 0.11490934590489 no 454 0.115585045293522 724 790957 SGTC_2054 5233173 129 µM 1.19532746986734 0.115309347423069 no 455 0.115979555605064 672 6889 SGTC_1896 st058441 89 µM 1.19023316227772 0.116321152352021 no 456 0.116977381212645 569 688759 SGTC_1230 0170-0365 3.77 µM 1.18995910398187 0.116375762384728 no 457 0.117031233124557 783 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3190 9110366 49.47 µM 1.18815334262834 0.116736040913346 no 458 0.1173865008837 532 17123768 SGTC_2235 salicylic acid 500 µM 1.18635642987052 0.117095338260254 no 459 0.117740785211365 605 338 A COX inhibitor and kinase inhibitor. SGTC_1455 4262-0120 131 µM 1.1850567383652 0.117355702782394 no 460 0.117997507177447 653 1529587 SGTC_2085 5307070 144.047 µM 1.18064022650839 0.118243516388512 no 461 0.118872838103292 579 2840351 SGTC_1829 berberine 14.4 µM 1.18028168617596 0.118315798543172 no 462 0.118944099773006 621 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1202 1988-0068 29.6 µM 1.17512410525657 0.119359030959268 no 463 0.119972534018788 659 2850480 SGTC_1401 3807-4679 7.6 µM 1.17461359011654 0.119462645656543 no 464 0.120074671867691 599 3291456 SGTC_1648 st011736 69.8 µM 1.1737116634263 0.119645856721333 no 465 0.120255268462271 633 2855514 SGTC_46 0329-0187a 2.197 µM 1.17270874784848 0.11984981455724 no 466 0.12045631109808 738 46494817 SGTC_2432 5630864 12.22 µM 1.17082993705357 0.120232558218081 no 467 0.120833570917208 632 5714970 SGTC_1741 st038134 10.228 µM 1.17052396678768 0.120294970682664 no 468 0.120895087521835 686 1272587 SGTC_902 1120-0002 2.07 µM 1.1705078888335 0.120298250928959 no 469 0.120898320671293 662 3280475 SGTC_1941 st076221 61.8 µM 1.1687230868342 0.120662780509635 no 470 0.121257608595468 703 2828568 SGTC_277 nystatin 15.5 µM 1.16715881886749 0.120982906887623 no 471 0.121573119015946 666 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2857 9024691 58.44 µM 1.16555887452339 0.121310952112098 no 472 0.121896421752225 592 16478292 SGTC_2777 climbazole 1.536 µM 1.16497398420623 0.121431031312537 no 473 0.122014761876075 680 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2825 7998094 58.44 µM 1.16386329586867 0.121659287896756 no 474 0.122239708090468 624 2987815 SGTC_1153 4055-0057 267 µM 1.16234993618614 0.121970782172793 no 475 0.122546675140801 677 882706 SGTC_2479 5617353 43.85 µM 1.16181999935996 0.122079991183649 no 476 0.122654294283528 655 2731746 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.15942974175553 0.1225734270565 no 477 0.123140529712195 757 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1920 st075728 45.7 µM 1.15803642961501 0.122861701935073 no 478 0.123424585126285 648 3400306 SGTC_1427 4048-4900 550 nM 1.1577113503052 0.122929028862338 no 479 0.123490925235414 652 24132586 SGTC_1610 st001799 48.1 µM 1.15617491799909 0.123247588224983 no 480 0.123804808489864 581 621897 SGTC_167 3672-0051 66.205 µM 1.15526724829585 0.123436053383667 no 481 0.123990501795205 604 3237971 SGTC_1867 st057372 64 µM 1.15508197673458 0.123474547277131 no 482 0.124028429047899 645 688837 SGTC_1064 honokiol 6.76 µM 1.15321339509782 0.12386325279432 no 483 0.124411403397144 680 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_552 k242-0005 476 µM 1.15060851897156 0.124406551565346 no 484 0.124946663356119 645 4088318 SGTC_1157 4092-0394 27.6 µM 1.15052974235624 0.124423007915989 no 485 0.124962875701257 719 3659885 SGTC_1661 st013063 9.66 µM 1.14963684612541 0.124609639390657 no 486 0.125146737808025 714 721395 SGTC_1962 st076595 64.5 µM 1.14881139358413 0.12478234790573 no 487 0.125316880118602 666 279619 SGTC_2139 5578692 56.4705 µM 1.14589022479245 0.125394883920877 no 488 0.125920288203731 611 650991 YMR113W FOL3 SGTC_958 1222-0007 33 µM 1.14374804113771 0.125845407431516 no 489 0.126364071818609 717 7312461 SGTC_938 3126-1755 342 µM 1.14366085798772 0.125863766832451 no 490 0.126382156090625 706 1777771 SGTC_14 0354-0009 295 µM 1.14010404912726 0.126614367971539 no 491 0.127121477604487 693 1713507 SGTC_1721 st082152 9.2685 µM 1.13971986261155 0.126695629862804 no 492 0.127201514681321 621 5296051 SGTC_3349 9149703 23.001 µM 1.13780528429474 0.127101136744785 no 493 0.127600898972853 640 4910494 SGTC_2107 5363541 170.161 µM 1.1368560663813 0.127302515227344 no 494 0.127799230367473 691 244052 SGTC_175 3793-3120 23.7 µM 1.13529967058181 0.127633187812669 no 495 0.128124890101869 623 5322297 SGTC_3131 9127911 49.47 µM 1.13412052992842 0.127884105824082 no 496 0.128371996540629 639 45595681 SGTC_1789 tunicamycin 25 nM 1.13318529406356 0.128083365142982 no 497 0.128568224251319 673 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2349 9023730 187.07 µM 1.13283223712655 0.12815864272986 no 498 0.128642355442353 658 4126287 SGTC_532 1548-0774 215 µM 1.13239870804801 0.128251120334298 no 499 0.128733423893772 702 5932993 SGTC_166 k072-0058 166.424 µM 1.13083396933925 0.128585285627145 no 500 0.129062489735045 678 5846229 SGTC_1516 st013856 110 µM 1.13005976301471 0.128750848233461 no 501 0.129225521461444 649 5281404 A mutagen and neurotoxin. SGTC_2928 9011484 9.79 µM 1.12936758661952 0.128898994059447 no 502 0.129371400213055 625 2994751 SGTC_1168 k815-0004 80.5 µM 1.1289185809413 0.128995157497969 no 503 0.129466090833591 673 642433 SGTC_7 0192-1582 4.227 µM 1.12833875581386 0.12911941209512 no 504 0.129588440943566 791 252616 SGTC_848 0368-0089 85.6 µM 1.12753584805192 0.129291609533671 no 505 0.129757996397655 708 762535 SGTC_1828 st055811 49 µM 1.12549227927026 0.129730606045483 no 506 0.130190243537217 635 5877589 SGTC_2641 levomentholum 100 µM 1.12251823929558 0.130371327554826 no 507 0.130821078462832 648 16666 SGTC_2441 5730946 39.09 µM 1.12014568841829 0.13088403257657 no 508 0.131325841868275 686 1774275 SGTC_1082 camptothecin 424.86 nM 1.11966675536978 0.130987698157968 no 509 0.131427898442674 604 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3220 9131269 49.47 µM 1.11815572338026 0.131315134469898 no 510 0.13175024539047 681 17722206 SGTC_2444 5485484 36.41 µM 1.11597649356847 0.13178836200291 no 511 0.132216098312571 721 6790631 SGTC_296 1222-0039 74.9 µM 1.11579119205237 0.131828655097339 no 512 0.132255762448685 641 5984176 SGTC_3201 9113999 49.47 µM 1.11451238590526 0.132106958232474 no 513 0.132529716925965 675 16649224 SGTC_139 0099-0334 718.624 µM 1.11361692852191 0.132302075199593 no 514 0.132721780431476 809 97690 SGTC_2412 st077135 33.4 µM 1.11244305636888 0.132558158498164 no 515 0.132973850398101 693 13258915 SGTC_1408 3909-7976 48.8 µM 1.11192158579564 0.132672028152348 no 516 0.133085933385688 744 24152374 SGTC_1924 st058459 75.1 µM 1.11159467740408 0.132743447057715 no 517 0.133156231036368 667 688683 SGTC_218 alverine citrate 93.75 µM 1.11112878793765 0.132845274580225 no 518 0.133256459020056 660 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_364 0083-0097 67.7 µM 1.10511190808355 0.134165192747418 no 519 0.134555550665643 707 5207356 SGTC_3137 9097352 49.47 µM 1.10502260223884 0.134184851309137 no 520 0.13457489774719 737 44120435 SGTC_391 gliotoxin 8.33 µM 1.10483256654549 0.134226689740288 no 521 0.134616073143377 742 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_645 0845-0943 5.41 µM 1.1038102795832 0.134451911104806 no 522 0.134837722373989 671 1885106 SGTC_2545 solidagenone 89.61 µM 1.10365614946521 0.134485890205195 no 523 0.134871162117908 460 6708572 An anti ulcer agent SGTC_2811 7967822 32.47 µM 1.10317896612484 0.134591126104518 no 524 0.134974726875455 702 2232244 SGTC_3261 9137475 49.47 µM 1.1020586181384 0.134838424775533 no 525 0.135218094217104 467 17027690 SGTC_2097 5376186 200 µM 1.1019121378075 0.134870780965012 no 526 0.135249935598314 712 742755 SGTC_3319 9138450 16.7555 µM 1.09904248331098 0.135505736303262 no 527 0.13587476790267 674 2029690 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.09812638341358 0.135708868174709 no 528 0.136074653064829 757 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2725 haloperidol 53.21 µM 1.09798648468383 0.135739907038409 no 529 0.136105195477674 705 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2745 rifampicin 24.3 µM 1.0969294722166 0.135974580016319 no 530 0.136336111995336 568 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2379 9035213 200 µM 1.09557267263783 0.136276217216751 no 531 0.136632913099036 770 646551 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.09112823229046 0.137267488602406 no 532 0.137608230790765 726 229346 A bile salt which induces apoptosis. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.08703095459878 0.138185682689196 no 533 0.138511564888189 758 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_583 1488-1091 88.9 µM 1.08387854345202 0.138894977776613 no 534 0.139209327129979 844 4303273 SGTC_921 1561-0023 372 µM 1.08341787199551 0.138998836467468 no 535 0.139311493224088 735 24050882 SGTC_2886 9058944 51.95 µM 1.08220274600047 0.139273041047424 no 536 0.139581224299268 553 4949929 SGTC_3195 9113082 49.47 µM 1.07832169331637 0.1401513009835 no 537 0.140445109634484 702 17018038 SGTC_19 0279-0214 38.434 µM 1.0771998190767 0.140405874132268 no 538 0.140695503050599 813 3566274 YBR002C RER2 SGTC_702 1488-0190 94 µM 1.07503569461216 0.140897838873141 no 539 0.141179373855283 724 949357 SGTC_87 0100-0052 35.5 µM 1.07464188190521 0.140987488889584 no 540 0.141267546581677 935 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1609 st001574 46.4 µM 1.07274928877756 0.141418870447201 no 541 0.141691809595065 734 3960012 SGTC_1993 st073995 70.8 µM 1.07239346892144 0.141500072785369 no 542 0.141771670095408 745 3098394 SGTC_2403 6032726 181.2 µM 1.07057341236476 0.141915925485893 no 543 0.142180641795261 701 2881040 SGTC_1066 ketoconazole 628 nM 1.06840516626656 0.142412412800198 no 544 0.142668893809431 778 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_743 1275-0778 158 µM 1.06742802585306 0.142636543069266 no 545 0.142889299281542 778 2849257 YMR203W TOM40 SGTC_1186 1319-0216 26 µM 1.06637193920718 0.142879049581756 no 546 0.143127770636659 779 4565136 SGTC_2421 5690543 90.72 µM 1.06626560607319 0.142903482022856 no 547 0.143151796251441 735 3397993 SGTC_3091 9116372 49.47 µM 1.06098664583764 0.144119992754251 no 548 0.144347985053816 688 17169793 SGTC_483 fpl-64176 144 µM 1.06036190522707 0.14426442191617 no 549 0.144489993004952 689 3423 SGTC_2005 4024620 188 µM 1.05964398261046 0.144430513579794 no 550 0.144653298089513 742 236743 SGTC_522 1273-0010 11.6 µM 1.05729658370731 0.144974484400581 no 551 0.145188125965857 713 5705015 SGTC_1267 0828-0272 9.49 µM 1.05455248817656 0.145612129490905 no 552 0.14581502154901 792 745334 SGTC_2397 5161689 200 µM 1.05117357209429 0.146399874633993 no 553 0.146589439324538 766 2259942 SGTC_2012 4023501 200 µM 1.05096511833413 0.146448566119933 no 554 0.14663730531905 683 3477460 SGTC_2870 9038528 12.99 µM 1.04830400966044 0.147071114046163 no 555 0.147249281430029 669 6463316 SGTC_1807 st050092 58.9 µM 1.04728117599477 0.147310870305127 no 556 0.147484957663336 716 5008496 SGTC_492 tmb-8 126 µM 1.04443596789503 0.14797917549144 no 557 0.148141864962816 595 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2309 7664088 163.95 µM 1.04419851148001 0.148035042758965 no 558 0.148196777753857 820 704922 SGTC_795 0685-0265 78 µM 1.04287299711374 0.148347160842523 no 559 0.148503558681498 784 302754 SGTC_264 promethazine 12.5 mM 1.04259023046981 0.148413800661756 no 560 0.148569057940893 891 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1600 coumarin 106 71.1 µM 1.04038476984437 0.148934250148249 no 561 0.149080587331793 782 100336 A hepatotoxic, DNA x-linker. SGTC_22 0964-0034 14.468 µM 1.03538923310754 0.150117612234595 no 562 0.150243585960353 792 138402 SGTC_1872 amphotericin b 148 nM 1.03530331069662 0.150138020547607 no 563 0.150263642097638 803 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_511 blebbistatin 171 µM 1.03490322528133 0.150233073292577 no 564 0.15035705412804 762 3476986 A myosin inhibitor. SGTC_533 1222-0222 6.71 µM 1.03441365128516 0.150349441391551 no 565 0.150471412604258 820 3982874 SGTC_1995 st072814 61.1 µM 1.03263630047005 0.150772409169601 no 566 0.15088706684659 750 5769371 SGTC_97 0535-0701 19.132 µM 1.03197924299386 0.150928973806034 no 567 0.151040920723023 722 2832013 YGL099W LSG1 SGTC_385 1494-0393 12.4 µM 1.03010055331941 0.151377227625312 no 568 0.15148140276246 794 3090647 SGTC_2978 9011784 42.97 µM 1.02965016547761 0.151484821225711 no 569 0.151587128559443 869 2994934 SGTC_1926 methyl fluorone black 53.6 µM 1.02632302854233 0.152281219175258 no 570 0.152369672993167 693 72721 Reacts with homocysteine. SGTC_274 sirtinol 40.1 µM 1.02541607718242 0.152498792224977 no 571 0.152583452709106 777 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1379 2144-0755 36.5 µM 1.02517662611277 0.152556269730282 no 572 0.152639927494167 826 5392327 SGTC_939 1165-0479 45.3 µM 1.02291770472431 0.15309920545466 no 573 0.153173378854254 788 1377347 SGTC_450 aminopyrene 156 nM 1.02259295910597 0.153177363799558 no 574 0.15325017000398 792 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_490 phenamil 164 µM 1.02102714390962 0.153554588369025 no 575 0.153620789322513 676 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1809 st050081 57.6 µM 1.01976555904098 0.153858967166887 no 576 0.153919830462024 785 5036894 SGTC_1335 1486-0900 202 µM 1.01481360420933 0.155057567908266 no 577 0.155097343795155 800 X1335 SGTC_2666 tannic acid 100 µM 1.01479348616402 0.155062449941413 no 578 0.155102139715065 819 16134267 A thiamine antagonist. SGTC_844 0330-0132 15.3 µM 1.01308180219981 0.155478194871355 no 579 0.155510544840561 844 2828079 SGTC_203 k066-0004 30.888 µM 1.01180787732688 0.155788090937346 no 580 0.155814961409708 932 6795412 SGTC_151 3013-0144 2.285 µM 1.01157454112309 0.155844896604442 no 581 0.155870761878112 796 906558 YHR107C CDC12 SGTC_2623 humulene 100 µM 1.01043614575173 0.156122234616795 no 582 0.15614318883951 672 6187145 An anti-inflammatory. SGTC_2367 9070478 135.38 µM 1.00813879839365 0.156682908465716 no 583 0.15669391697425 781 572802 SGTC_1550 gossypolone 36.6 µM 1.0080147910735 0.15671321044205 no 584 0.156723680767169 824 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3287 9117173 37.0625 µM 1.00796734571968 0.156724805035723 no 585 0.156735069415201 762 2789709 SGTC_2119 5528445 120.635 µM 1.00720182336747 0.156911959788658 no 586 0.156918898517439 785 791935 SGTC_1444 4112-3581 28 µM 1.00641343746951 0.157104857847756 no 587 0.15710836617795 826 2877249 SGTC_1257 0669-0121 16 µM 1.00488708954664 0.157478759594511 no 588 0.157475610892926 872 4307855 SGTC_714 4296-0578 26.1 µM 1.00322516737842 0.157886536776616 no 589 0.157876116296027 779 1589775 SGTC_2919 7978188 46.38 µM 1.00232425184858 0.15810787928463 no 590 0.158093506607774 816 2980291 SGTC_2438 5259590 200 µM 1.00180448405248 0.158235671662937 no 591 0.158219015565706 843 1201127 SGTC_2340 7987427 183.45 µM 1.00097554950459 0.158439617335773 no 592 0.158419314652395 766 2239331 SGTC_2486 5283202 22.39 µM 0.997943374123176 0.159187102336771 no 593 0.159153408917572 750 1377751 SGTC_2540 epiandrosterone 100 µM 0.997490374721585 0.159298972719254 no 594 0.159263271769858 952 441302 A steroid. SGTC_1262 0737-0114 49.6 µM 0.996950609724464 0.159432337485604 no 595 0.15939424212042 879 765919 SGTC_1700 st030840 7.9285 µM 0.995393510530983 0.159817473955952 no 596 0.15977245679524 835 5499307 SGTC_2865 9030313 51.95 µM 0.994608309993941 0.160011917898792 no 597 0.159963402134879 748 42562754 SGTC_2109 5483026 200 µM 0.992998076414943 0.160411153469283 no 598 0.160355445947183 822 759335 SGTC_3350 9150499 3.57 µM 0.992892360884316 0.160437386949823 no 599 0.160381206469478 853 4910996 YPR165W RHO1 SGTC_2507 purpurin 79.67 µM 0.989694173098498 0.161232347507442 no 600 0.161161811969219 806 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3054 9094397 49.47 µM 0.988982267145272 0.161409652145145 no 601 0.161335908901117 823 2598354 SGTC_663 1486-0733 13.9 µM 0.986222608129814 0.162098163821517 no 602 0.16201194371701 835 722445 YPR165W RHO1 SGTC_2947 9072639 7.68 µM 0.982475967841869 0.163035975488991 no 603 0.162932708382001 886 16488146 SGTC_1681 tripelennamine 100 µM 0.978743859452718 0.163973648996723 no 604 0.163853277557587 767 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2831 7999036 19.48 µM 0.977596735945381 0.164262559652402 no 605 0.164136906172579 873 2988270 SGTC_154 3389-1638 511.116 µM 0.977444050722695 0.164301039313951 no 606 0.164174681902888 730 5238686 SGTC_2114 5491910 81.25 µM 0.973661017839669 0.165256303702396 no 607 0.165112439397765 828 2849228 SGTC_80 0159-0065 512.242 µM 0.972864056473286 0.165458004134337 no 608 0.165310435567572 745 1548079 SGTC_665 3914-0008 307 µM 0.972380063408232 0.165580574100496 no 609 0.165430753203132 801 1069549 SGTC_2076 5212012 200 µM 0.969011820406773 0.166435198595387 no 610 0.1662696457761 747 604802 SGTC_2828 7998861 71.43 µM 0.96513985299689 0.167421145277007 no 611 0.167237384000015 769 2988188 SGTC_3268 9137683 49.47 µM 0.964925897607323 0.167475735768531 no 612 0.167290964477451 817 1953228 SGTC_770 0389-1121 67.2 µM 0.964447626876392 0.16759780750609 no 613 0.167410776992495 892 6753108 SGTC_947 3447-0010 211 µM 0.95929515112029 0.168916536150655 no 614 0.168705038707148 828 748350 SGTC_2841 9004761 38.96 µM 0.95604138660634 0.169752731587227 no 615 0.169525662759795 763 2991039 SGTC_3255 9139072 49.47 µM 0.955986529817786 0.169766852128233 no 616 0.169539519975237 857 17646060 SGTC_1467 k284-1082 293 µM 0.955090128362979 0.169997699176248 no 617 0.169766060326329 876 3334705 SGTC_738 1315-0003 72.4 µM 0.953420831733334 0.170428123111805 no 618 0.170188445373743 867 6251474 SGTC_2283 7944793 200 µM 0.950525412288012 0.171176353394963 no 619 0.17092267387308 854 2970533 SGTC_2717 st081029 62.2815 µM 0.947585221117442 0.171938299735095 no 620 0.171670326386789 842 5292846 SGTC_2555 cholic acid 100 µM 0.946019821565115 0.172344852797985 no 621 0.172069238180638 854 6708657 Influences liver metabolism. SGTC_271 rotenone 740 µM 0.945589755331025 0.172456653462297 no 622 0.172178935765001 859 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2025 5147754 141 µM 0.945327072499495 0.17252496363597 no 623 0.17224596058516 856 315777 YLR208W SEC13 SGTC_2499 avocadenofuran 51.48 µM 0.945178179184042 0.172563690722177 no 624 0.172283958840599 820 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_749 1000-0129 128 µM 0.94432250074047 0.172786359767444 no 625 0.172502435572045 908 708470 SGTC_2768 sulfasalazine 50.2 µM 0.943177157591853 0.173084693330077 no 626 0.172795147561663 873 5384001 An antioxidant and salicylic acid derivative. SGTC_2001 4023502 57.655 µM 0.940285349587877 0.173839396816495 no 627 0.173535606175592 845 108941 YCR052W RSC6 SGTC_2628 lathosterol 100 µM 0.934946556097269 0.175238203435383 no 628 0.174907921285783 868 6710616 SGTC_2698 st077697 67.5 µM 0.933554209196123 0.175604179762821 no 629 0.17526694756545 820 3154499 SGTC_3038 9091290 49.47 µM 0.930286988146872 0.176464864112468 no 630 0.176111256511744 854 25236843 SGTC_418 lividomycin a 100 µM 0.929565248708417 0.176655351239661 no 631 0.176298113649598 928 72394 An antibiotic. SGTC_2728 chlorpromazine 9.18 µM 0.927254580098533 0.17726607504191 no 632 0.17689718526824 796 2726 A thorazine and dopamine antagonist. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.926554255993021 0.177451437958048 no 633 0.177079007379708 829 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3241 9133421 49.47 µM 0.92407739732922 0.178107998073139 no 634 0.177723010202261 900 17018221 SGTC_2879 9041815 71.43 µM 0.923373227384372 0.178294937078811 no 635 0.177906369382616 802 4942971 SGTC_3150 9097574 49.47 µM 0.922218671784047 0.178601709334021 no 636 0.178207262786937 881 17217476 SGTC_62 0180-0423 3.232 µM 0.920910234404642 0.178949770440996 no 637 0.17854864742057 873 30102 YGL099W LSG1 SGTC_872 0588-0139 234 µM 0.911322222751918 0.181513313118527 no 638 0.181062810334905 923 2047100 SGTC_854 0422-0053 192 µM 0.910786082949583 0.181657335987983 no 639 0.181204048359155 916 3596728 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.909013333108296 0.182134057483604 no 640 0.181671543945439 944 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1382 3002-2117 298 µM 0.907860578799743 0.182444471227549 no 641 0.181975943759259 970 1497314 SGTC_1047 2043-3044 82 µM 0.906689529571327 0.182760149611751 no 642 0.182285500946197 931 669592 SGTC_1530 rhein 70.4 µM 0.905192981318495 0.183164068384984 no 643 0.182681579770006 982 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2443 5493264 126.67 µM 0.901179586093077 0.184250030977479 no 644 0.183746421506947 919 5340055 SGTC_317 4495-0002 170 µM 0.900128753028055 0.184535030688674 no 645 0.184025868050076 867 15991618 SGTC_3228 9131799 49.47 µM 0.896946941787637 0.185399650303844 no 646 0.184873614963431 878 17015818 SGTC_616 4092-0450 108 µM 0.892212011496716 0.186690958673824 no 647 0.186139652616004 933 787165 SGTC_672 1441-0018 53.7 µM 0.891831986027364 0.186794839892806 no 648 0.186241497215534 870 251141 SGTC_2971 9092186 9.93 µM 0.891005797849752 0.18702080456988 no 649 0.186463029915008 834 25236400 SGTC_3326 9140064 16.379 µM 0.888629322025369 0.18767171928873 no 650 0.187101163534291 923 1868434 SGTC_464 bw-b 70c 158 µM 0.888157291380934 0.187801174488315 no 651 0.187228074278677 958 5353454 SGTC_12 0849-0099 9.267 µM 0.88782634531993 0.187891969882792 no 652 0.187317084582427 902 6071388 SGTC_279 1273-0055 2.93 µM 0.886447365533168 0.188270586106305 no 653 0.187688252574738 1011 2847562 SGTC_100 0086-0128 49.5915 µM 0.886280949067137 0.188316309647107 no 654 0.187733076150015 965 93297 SGTC_2199 6590217 200 µM 0.884146734419791 0.188903300147032 no 655 0.188308503892511 884 703109 SGTC_2158 5657123 3.6195 µM 0.883649909221835 0.189040107632426 no 656 0.188442614058006 944 2858827 SGTC_1173 0443-0020 122 µM 0.882995508589062 0.189220398731872 no 657 0.188619349106702 920 5331295 SGTC_2354 9060492 162 µM 0.882363427545007 0.189394641135666 no 658 0.188790153253824 986 6471895 SGTC_2664 lyso-paf C-16 73.48 µM 0.880417405199862 0.189931710473282 no 659 0.18931661551158 983 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2489 cantharidin 73.42 µM 0.877269279809561 0.190802520026942 no 660 0.190170196991182 922 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_849 0386-0493 241 µM 0.877030254241804 0.190868737303398 no 661 0.190235102735729 923 726119 SGTC_2853 9015042 58.44 µM 0.875867372236039 0.191191091724306 no 662 0.190551069453083 910 6457456 SGTC_1337 1486-1011 40.3 µM 0.873420077969436 0.191870578624479 no 663 0.191217075598268 990 X1337 SGTC_1908 st060353 56.5 µM 0.87219503695932 0.192211263594447 no 664 0.191550993291708 998 4227716 SGTC_263 alizarin 107.927 µM 0.871758584960211 0.192332730622972 no 665 0.191670046210146 995 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_864 0469-0573 172 µM 0.869281442086844 0.19302302222984 no 666 0.192346605418743 901 689425 SGTC_95 0471-0001 561.058 µM 0.868592800788007 0.193215190477183 no 667 0.192534946790908 932 4015405 SGTC_680 0417-1641 114 µM 0.868086377828952 0.193356584417846 no 668 0.192673523891066 882 2835990 SGTC_2783 7738165 71.43 µM 0.867447552425313 0.193535035318927 no 669 0.192848418383724 844 17201110 SGTC_1180 1193-0155 285 µM 0.866632705107183 0.193762802302514 no 670 0.193071643984658 904 2921347 SGTC_785 1270-0111 65.3 µM 0.864001285721095 0.194499454683107 no 671 0.193793592128338 999 6741994 SGTC_2663 amphotericin b 100 µM 0.863951156618595 0.194513504594228 no 672 0.193807361349341 944 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_145 3737-0113 38.366 µM 0.863747958872942 0.194570462075208 no 673 0.193863180837499 1063 6849351 SGTC_906 1165-0455 526 µM 0.861771863347938 0.195124902013825 no 674 0.194406535528442 920 3252859 SGTC_652 0437-0092 114 µM 0.861075157702867 0.195320607861118 no 675 0.194598325185229 947 3091274 SGTC_617 3770-0098 35 µM 0.858733734729636 0.195979191062591 no 676 0.195243717073308 915 5962639 SGTC_767 0929-0023 86 µM 0.858569562485998 0.196025419057697 no 677 0.19528901839835 1013 1204563 SGTC_1196 1588-0294 184 µM 0.856829272982772 0.196515860336554 no 678 0.195769622591159 909 6144269 SGTC_2801 7907800 81.82 µM 0.855171957976705 0.196983608596749 no 679 0.196227978976278 964 6620925 SGTC_537 1334-0398 209 µM 0.853773222672428 0.19737890116678 no 680 0.196615326968708 1002 5846986 SGTC_2157 5649910 96.377 µM 0.853370004178318 0.197492942608747 no 681 0.19672707513221 940 2858091 SGTC_2365 9042475 200 µM 0.853114791553875 0.197565144444225 no 682 0.19679782475397 950 6464479 SGTC_2639 lactacystin 53 µM 0.851432582651541 0.198041454854908 no 683 0.197264549300378 973 3870 A proteasome inhibitor. SGTC_2028 5153890 36.43 µM 0.851301566865749 0.198078580511483 no 684 0.197300927378243 940 2830968 YPR165W RHO1 SGTC_576 1073-0113 22.7 µM 0.851078121412431 0.198141907455483 no 685 0.197362979004391 1187 5439563 SGTC_1875 nocodazole 6 µM 0.849908094786777 0.198473705639036 no 686 0.197688092380823 978 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3021 9087658 49.47 µM 0.849506384478912 0.198587700601323 no 687 0.197799789561992 978 25237042 SGTC_1871 st057448 67.3 µM 0.848207882706306 0.198956451759272 no 688 0.198161104010163 992 691747 SGTC_2030 5175110 200 µM 0.844098375106502 0.20012619466695 no 689 0.199307217820255 980 2831986 SGTC_2055 5235184 200 µM 0.843771085699805 0.200219532717004 no 690 0.199398667910913 948 2836034 SGTC_3089 9117425 49.47 µM 0.842485639334157 0.200586375889177 no 691 0.199758087339873 918 9401657 SGTC_1107 amlodipine 47 µM 0.841921514862876 0.200747494160255 no 692 0.199915943296646 932 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2175 5807670 165.306 µM 0.841763126826752 0.200792744959716 no 693 0.199960277664171 978 241186 SGTC_2520 obtusaquinone 4.71 µM 0.840817624019143 0.201062998480675 no 694 0.200225056147794 994 5967872 SGTC_595 3909-8003 73.7 µM 0.83971288766102 0.201379042031185 no 695 0.200534693133455 994 699517 SGTC_900 1112-0045 141 µM 0.839236146742435 0.201515520241821 no 696 0.200668403487997 886 56211 YIL048W NEO1 SGTC_1206 3978-0017 132 µM 0.838741226718149 0.201657261260862 no 697 0.200807269098975 950 3873677 SGTC_2754 granisetron 64.02 µM 0.836528180398801 0.202291789673149 no 698 0.201428915054911 968 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1667 st014849 34.6 µM 0.836213569801128 0.202382092214642 no 699 0.201517382888302 1014 5348460 SGTC_1222 0366-0074 1.18 µM 0.836151273313351 0.202399976006959 no 700 0.201534903289662 1041 286520 SGTC_1088 bifonazole 369 nM 0.835633193065957 0.202548740733259 no 701 0.201680644672222 961 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_6 0844-0013 19.835 µM 0.835615286280176 0.202553883765462 no 702 0.201685683166418 1162 1584900 SGTC_1984 st072354 53.1 µM 0.832508509843448 0.20344736644243 no 703 0.202560988406732 982 5762938 SGTC_1463 k081-0032 34.1 µM 0.830870105497434 0.203919503115433 no 704 0.203023506634471 866 977755 SGTC_954 1189-0853 2.85 µM 0.829544576802058 0.204301956237011 no 705 0.203398161784745 1055 2828194 SGTC_1093 fluphenazine 7.97 µM 0.829327160015304 0.204364727973201 no 706 0.203459653086133 1036 6602611 An atypical antipsychotic. SGTC_3159 9100096 49.47 µM 0.829158754296096 0.204413357313027 no 707 0.203507290363309 1010 25236875 SGTC_1910 st062352 60.4 µM 0.82859427039588 0.204576409605531 no 708 0.203667015619275 1021 2245730 SGTC_106 0092-0003 11.579 µM 0.827367724853389 0.204930966373461 no 709 0.204014334101756 965 1072148 SGTC_283 0987-0079 11.7 µM 0.8270191327573 0.20503180030904 no 710 0.20411310859841 1046 411556 SGTC_141 0443-0274 32.331 µM 0.826938397827566 0.205055157943211 no 711 0.204135989117267 1151 1627241 SGTC_1171 0368-0077 21.4 µM 0.825901581920983 0.205355262423201 no 712 0.204429961586309 947 3239779 SGTC_1156 4092-0367 4.88 µM 0.822384965264412 0.206375081891533 no 713 0.205428916716636 1000 1357585 SGTC_1062 mesoridazine 14.2 µM 0.822176813286102 0.206435539932162 no 714 0.205488136579894 1003 4078 A neuroleptic. SGTC_2985 9022375 71.43 µM 0.819984992508843 0.207072794189528 no 715 0.206112331292763 1040 4939335 SGTC_1466 k213-0079 57.5 µM 0.8190820072166 0.207335668031373 no 716 0.206369813377171 1014 3657981 SGTC_1329 1447-1697 50.6 µM 0.818679832469585 0.207452811182939 no 717 0.206484552972505 986 2840515 SGTC_476 mead acid 10 µM 0.817384978106473 0.207830234582083 no 718 0.206854228786259 1007 5312531 An omega 9 fatty acid. SGTC_1888 azatryptophan 97.5 µM 0.816099171399394 0.208205421762708 no 719 0.207221708906824 916 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1470 k295-0292 231 µM 0.815440748444319 0.208397698461639 no 720 0.207410033806443 1043 5045612 SGTC_2067 5224629 34.075 µM 0.814893363303159 0.208557628916071 no 721 0.207566676198538 1026 2835000 SGTC_1137 ixabepilone 100 µM 0.813772444199654 0.208885355494359 no 722 0.207887661928111 999 154225 A novel microtubule stabilizer. SGTC_3316 9136639 10.545 µM 0.812712049933624 0.209195665328115 no 723 0.208191585433203 1010 4903665 SGTC_3338 9144300 39.5675 µM 0.811530768468587 0.209541670496431 no 724 0.208530465402185 1023 4901274 SGTC_916 4466-0038 42 nM 0.811188764669656 0.209641908480511 no 725 0.208628638377273 1095 5722064 YGL116W CDC20 SGTC_1475 4092-1048 11.7 µM 0.808706401914164 0.210370309564131 no 726 0.209342022448159 1043 2881759 SGTC_1054 3429-0080 167 µM 0.807340677966997 0.210771687504905 no 727 0.209735117069839 1059 1162877 SGTC_3165 9101544 49.47 µM 0.807129354537391 0.210833834276745 no 728 0.209795980778611 1027 5002184 SGTC_615 k087-0205 167 µM 0.806458514803076 0.211031188484868 no 729 0.20998925953803 1007 9642773 SGTC_1465 k213-0056 144 µM 0.806060765609693 0.211148253360959 no 730 0.210103906303883 972 24048857 YMR208W ERG12 SGTC_1588 farnesol 29.9 µM 0.805659138541604 0.211266498172077 no 731 0.210219708125993 1009 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2402 5553605 200 µM 0.805026946265727 0.211452703284511 no 732 0.210402065131572 1054 6758546 SGTC_2232 chlorophetanol 41.5365 µM 0.804498432561878 0.211608444773682 no 733 0.210554587109655 1125 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2959 9079155 11 µM 0.803445612789355 0.211918887890074 no 734 0.210858610087974 1002 16189457 SGTC_572 0960-0087 17.7 µM 0.802836802785911 0.212098528133503 no 735 0.211034533686115 1096 6796365 SGTC_807 1315-0151 48 µM 0.799828142697922 0.212987593252853 no 736 0.211905187614409 1099 4011080 SGTC_1933 st074711 15.9 µM 0.79930647073344 0.213141969277059 no 737 0.212056363882375 1086 17250958 SGTC_2021 4019055 173 µM 0.796417267744856 0.213998138924005 no 738 0.212894772439305 1087 44827708 YER133W GLC7 SGTC_1917 st066507 28.5 µM 0.796139046803567 0.214080690840102 no 739 0.21297561047266 1030 3156428 SGTC_892 0929-0076 29 µM 0.79365324085307 0.214819085189643 no 740 0.213698664281928 1071 5751038 SGTC_2388 9080168 200 µM 0.792404950061332 0.215190440148163 no 741 0.214062297020223 993 15943073 SGTC_2592 piperlongumine 83.33 µM 0.792210014700352 0.215248465233207 no 742 0.214119115062122 1017 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_91 0417-1751 58.384 µM 0.790925399775814 0.215631074857375 no 743 0.214493762720393 1206 6795624 SGTC_1390 3413-2614 145 µM 0.790799225588425 0.215668675825279 no 744 0.214530580956161 1109 3421432 SGTC_2785 7756463 72.73 µM 0.790206147388064 0.215845469033736 no 745 0.214703693248981 1085 2201551 SGTC_1398 3558-0053 112 µM 0.789986342789195 0.215911012849427 no 746 0.214767872142323 998 4532369 SGTC_3078 9116413 49.47 µM 0.789298869489896 0.21611608582316 no 747 0.214968673616251 1040 17177322 SGTC_2129 girgensonine 121.053 µM 0.789236344837844 0.21613474249327 no 748 0.214986941612696 1092 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1818 st052136 56.3 µM 0.786913981181541 0.216828370782782 no 749 0.215666111238706 993 674169 SGTC_320 4092-0846 5.34 µM 0.786820820150164 0.216856222329712 no 750 0.215693381883176 1067 1359356 SGTC_2466 5983409 37.09 µM 0.786221489120577 0.217035448584188 no 751 0.215868869377026 1004 2879657 SGTC_651 3253-0966 34.4 µM 0.785060702014415 0.217382818157745 no 752 0.216208989573295 1076 781462 SGTC_2345 9052315 157.45 µM 0.783745419869734 0.217776808583487 no 753 0.216594752822917 1029 6469265 SGTC_380 3970-0968 6 µM 0.781396935717252 0.218481316230903 no 754 0.21728453641317 1024 2891601 SGTC_2576 guaiol 23.12 µM 0.780516833074741 0.218745670637941 no 755 0.217543361674272 1094 227829 SGTC_2570 licareol 100 µM 0.779177253504735 0.219148390180794 no 756 0.217937653702055 993 443158 SGTC_192 3455-0609 60.9 µM 0.778702463161366 0.219291229269253 no 757 0.218077502403724 1074 3769639 SGTC_2215 7188065 200 µM 0.777563902470668 0.219633979372748 no 758 0.218413074227083 1073 940217 SGTC_316 k060-0003 58.6 µM 0.77661195162915 0.219920788797383 no 759 0.218693874045378 1071 6152314 SGTC_1437 4092-1038 11.6 µM 0.77657046865073 0.219933291921475 no 760 0.218706115127691 1100 3977136 SGTC_973 1325-0077 65.9 µM 0.775161544936467 0.220358188905019 no 761 0.219122104108845 1121 2835149 SGTC_1779 st039427 55 µM 0.774308336764858 0.220615724249284 no 762 0.219374237405976 1141 1124498 SGTC_1866 st057638 64 µM 0.771449761131343 0.22147982227601 no 763 0.220220194859556 1051 688802 SGTC_2460 5552655 174.22 µM 0.769326504318106 0.222122896477281 no 764 0.220849753418972 1095 5401989 SGTC_444 curcumin 90.4 µM 0.768526043547692 0.222365609664939 no 765 0.221087362111942 1033 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1820 st053765 18.6 µM 0.768338468778083 0.222422507365961 no 766 0.221143062935767 1084 3690829 SGTC_2202 7226349 200 µM 0.766609993295491 0.222947202435748 no 767 0.221656716039953 1067 844334 SGTC_394 menadione 8.33 µM 0.766083092516757 0.223107288256095 no 768 0.221813431249353 1075 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2070 5230947 200 µM 0.765963593513149 0.223143604187375 no 769 0.221848982438968 1176 2835538 SGTC_1232 0279-0259 161 µM 0.764216360682999 0.223674975141377 no 770 0.222369159186566 1092 1560000 SGTC_425 3825-7017 13.1 µM 0.763322818582359 0.223946998258841 no 771 0.222635448380164 1090 3397440 SGTC_2972 9093619 59.92 µM 0.762706614565581 0.224134700155713 no 772 0.222819192444768 1067 25236256 SGTC_1913 st060213 96.1 µM 0.762482282489856 0.224203056125183 no 773 0.222886106815582 1117 688959 SGTC_134 0269-0018 6.916 µM 0.761920697456732 0.22437422795694 no 774 0.223053668090968 1011 4378915 SGTC_3074 9116018 49.47 µM 0.75991669469877 0.224985654816786 no 775 0.22365219088154 1119 17027303 SGTC_1372 2752-0194 270 µM 0.759221957122683 0.225197841419535 no 776 0.223859896724819 1044 823334 SGTC_830 4076-0286 57.8 µM 0.758998679404428 0.22526605891448 no 777 0.22392667338348 1165 6866659 SGTC_1162 k048-0130 20.1 µM 0.758199283238836 0.225510392405987 no 778 0.22416584512985 1061 6797406 SGTC_1176 0848-0131 83.3 µM 0.757273265385457 0.225793614936337 no 779 0.224443082157408 1170 6769040 SGTC_634 1611-4317 11.2 µM 0.757259347821099 0.225797873156983 no 780 0.224447250368723 1136 2843522 SGTC_2409 alverine citrate 63.97 µM 0.756948293258908 0.225893055321091 no 781 0.224540420454812 1080 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1459 k035-0031 35.7 µM 0.756049555706418 0.226168194916181 no 782 0.224809742322953 980 3877128 YMR208W ERG12 SGTC_1804 st050076 49.1 µM 0.755071046512441 0.226467971020044 no 783 0.225103177263823 1080 3895976 SGTC_1758 st042942 75.2445 µM 0.754423679288583 0.226666421714749 no 784 0.225297428699723 1098 669317 SGTC_2145 5634607 200 µM 0.754176003611674 0.226742372747172 no 785 0.225371772291274 1080 308662 SGTC_3027 9089541 49.47 µM 0.752968430212168 0.227112887023713 no 786 0.225734442558789 1110 9943819 SGTC_3020 9089140 49.47 µM 0.751842738836884 0.227458584981268 no 787 0.22607281833564 1142 17217859 SGTC_2053 5265679 138 µM 0.751460642153548 0.227575993580478 no 788 0.226187739343774 1111 764595 SGTC_1443 4112-3303 14 µM 0.750251055279482 0.22794789379861 no 789 0.226551757352642 1129 704433 SGTC_299 1273-0059 1.44 µM 0.750177391457998 0.227970553555399 no 790 0.226573936722385 1079 2848077 SGTC_2840 9008771 71.43 µM 0.748166924617549 0.228589483045839 no 791 0.227179739306816 1092 2992978 SGTC_2935 9038016 29.96 µM 0.747396496041656 0.228826912163745 no 792 0.227412129927304 1124 6463195 SGTC_2544 sphondin 68.51 µM 0.746643839422479 0.22905899796808 no 793 0.227639289105581 1130 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_800 3448-7362 155 µM 0.743609786923779 0.229995902562339 no 794 0.228556290300709 1231 15991913 SGTC_2453 5731132 22.18 µM 0.742704060688682 0.230276002705284 no 795 0.228830435375526 1155 1362040 SGTC_1413 3910-0535 34.4 µM 0.741993154186794 0.230495987486427 no 796 0.229045741671933 1129 2876951 SGTC_221 trifluoperazine 10.304 µM 0.741478675212204 0.230655262451235 no 797 0.229201628466346 1183 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3269 9137823 49.47 µM 0.740402601822239 0.230988597342006 no 798 0.229527870282852 1056 17682936 SGTC_2052 5265182 7.135 µM 0.740006140586617 0.231111476762055 no 799 0.229648134180848 1115 1239884 SGTC_2198 6589944 200 µM 0.737934348875711 0.231754202116296 no 800 0.230277172356215 1058 5290268 SGTC_3135 9127742 49.47 µM 0.73786183848076 0.231776714807915 no 801 0.230299205428243 1056 3643468 SGTC_783 0848-0141 92.7 µM 0.737022419579387 0.232037422373363 no 802 0.230554357792836 1092 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2898 9056270 58.44 µM 0.736762124274991 0.232118298300574 no 803 0.230633510036106 1068 19154699 SGTC_1338 1486-1223 76 µM 0.735944664830678 0.23237239177144 no 804 0.230882186966407 1143 3444526 SGTC_2440 5628896 157.78 µM 0.735636117887656 0.232468338587041 no 805 0.230976088029916 1124 5522048 SGTC_1183 1254-0324 198 µM 0.733874418733532 0.233016584403677 no 806 0.231512639667227 1146 5799357 SGTC_1935 st074532 41.6 µM 0.732403304330557 0.233474949020122 no 807 0.231961221273965 1215 2829742 SGTC_499 genistein 192 µM 0.732212654783241 0.233534387516086 no 808 0.232019390758092 1147 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_792 4534-1957 155 µM 0.731741176943899 0.233681415419862 no 809 0.232163279224474 1101 1717904 SGTC_136 0097-0015 404.482 µM 0.730567418661138 0.234047668621137 no 810 0.232521709525802 1187 4861337 SGTC_3101 9120531 49.47 µM 0.729499913826803 0.23438104295109 no 811 0.232847960237941 1163 24824904 SGTC_2896 9052656 71.43 µM 0.728466334020655 0.234704072956371 no 812 0.233164084965728 1147 6469436 SGTC_2620 irigenin 100 µM 0.723018759875783 0.236410692579749 no 813 0.234834179375932 1171 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1028 k015-0029 4.8 µM 0.720946675614594 0.237061625351241 no 814 0.235471161841071 1170 4588309 SGTC_2813 7971799 71.43 µM 0.720497116141788 0.237202981658847 no 815 0.235609487339363 1147 2234054 SGTC_331 k048-0133 24.5 µM 0.716706898900481 0.23839658966832 no 816 0.236777484077569 1152 6813582 SGTC_3086 9117350 49.47 µM 0.71529618631632 0.23884168705969 no 817 0.237213022298783 1110 2679265 SGTC_1769 st044406 64.4 µM 0.713405817123423 0.239438834023927 no 818 0.237797337255083 1178 670903 SGTC_540 1187-0821 17.3 µM 0.713259108153713 0.239485211851878 no 819 0.237842718126949 1161 847520 SGTC_1531 st059297 52.4 µM 0.711002949275176 0.240199049053014 no 820 0.238541204099503 1178 7566702 SGTC_2649 anisomycin 9.56 µM 0.708660836407857 0.240941306681677 no 821 0.239267486870739 1147 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2270 7924575 90.91 µM 0.708335461758042 0.241044522358934 no 822 0.239368480146503 1156 1262135 SGTC_412 gemfibrozil 100 µM 0.706383464657636 0.241664241347864 no 823 0.2399748505122 1173 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_547 1120-0019 610 nM 0.70616808439665 0.241732673100291 no 824 0.240041807728493 1134 3676939 SGTC_1965 Pectolinarigenin 58.4 µM 0.705752644646651 0.241864698512085 no 825 0.240170988020725 1190 5320438 An anti-inflammatory. SGTC_2095 5432005 200 µM 0.705095913701544 0.2420734852692 no 826 0.240375274672882 1182 783734 SGTC_2627 acetyl isogambogic acid 100 µM 0.702784361378983 0.242809146736776 no 827 0.241095072282538 1158 6857789 A caspase activator and apoptosis inducer. SGTC_1711 st032263 62.8 µM 0.702065992021439 0.24303801706481 no 828 0.24131900480194 1181 3958979 SGTC_1849 st056239 19.2 µM 0.69951148682805 0.243852819100396 no 829 0.242116218460677 1143 5393181 SGTC_1029 k015-0030 64.7 µM 0.698562375760958 0.24415592909854 no 830 0.242412781841715 1164 2208316 SGTC_70 0141-0289 43.283 µM 0.698405192882204 0.244206146937094 no 831 0.242461914877153 1237 352408 SGTC_2338 7999974 200 µM 0.69739323612981 0.244529586950988 no 832 0.242778366665426 1243 315925 SGTC_567 1080-0542 68.4 µM 0.696223884204958 0.244903620562885 no 833 0.243144316154787 1127 5950415 SGTC_1901 st060216 58.6 µM 0.694445877394961 0.245472930430668 no 834 0.243701315657283 1208 688792 SGTC_2275 7947463 200 µM 0.694130064060494 0.245574126772012 no 835 0.243800323087185 1158 1225414 SGTC_2629 bisabolol 100 µM 0.694067145718889 0.245594290427529 no 836 0.243820050570402 1194 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1405 3909-7894 12 µM 0.692958136149597 0.245949844436739 no 837 0.244167911984359 1199 7104060 SGTC_2920 7982904 15.77 µM 0.690481987458913 0.246744705900576 no 838 0.244945566762955 1173 6456808 SGTC_1847 st056231 15 µM 0.690069582556799 0.246877224317026 no 839 0.24507521524091 1233 5393180 SGTC_258 haloperidol 50.781 µM 0.687629790224156 0.247661983543867 no 840 0.245842971718454 1184 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2144 5628481 200 µM 0.685614795546167 0.248311109765862 no 841 0.246478024505101 1198 2818399 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.684286511381647 0.248739509189349 no 842 0.246897131403734 1220 688761 SGTC_2298 7976326 193.81 µM 0.681335920533173 0.249692542827765 no 843 0.247829479661248 1113 2235818 SGTC_1617 st002906 78 µM 0.680481457093638 0.249968894102576 no 844 0.248099829506943 1233 5150859 SGTC_2241 6772625 37.8075 µM 0.679152204981322 0.250399124366959 no 845 0.248520713694459 1173 2285411 SGTC_602 3130-1533 38.1 µM 0.6790181195137 0.250442544708003 no 846 0.248563190600982 1236 720941 SGTC_1236 0330-0013 258 µM 0.67728567840175 0.25100391259026 no 847 0.24911235790621 1212 4617066 SGTC_179 1273-0063 6.77 µM 0.67721830939393 0.251025755805264 no 848 0.249133726268333 1201 3108139 SGTC_1377 2944-0135 198 µM 0.67711165730917 0.251060337922893 no 849 0.249167556581898 1280 1894137 SGTC_2449 5812982 45.77 µM 0.676402802958274 0.251290249170162 no 850 0.249392469063907 1193 776185 SGTC_3312 9133330 71.43 µM 0.673647340841983 0.252185017633627 no 851 0.250267773992591 1253 17617324 SGTC_764 1951-2361 146 µM 0.673078815947961 0.252369840976787 no 852 0.250448575112649 1208 5438930 SGTC_678 1218-2179 85.9 µM 0.672450800804961 0.25257408713922 no 853 0.250648375637549 1231 6820081 YOR116C RPO31 SGTC_2738 aclarubicin 5.55 µM 0.672206140170803 0.252653680433968 no 854 0.250726236293191 1141 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2074 5212007 75.395 µM 0.671776497272471 0.252793484346161 no 855 0.250862996583978 1172 758611 SGTC_2521 angolensin 13.4 µM 0.671700062718282 0.252818360081106 no 856 0.250887330721046 1250 821428 A flavenoid. SGTC_1120 ficusin 1.78878 µM 0.671290877386526 0.252951551944735 no 857 0.251017622523215 1276 6199 A DNA cross-linker. SGTC_2966 9084041 48.03 µM 0.667249761480331 0.254268935927902 no 858 0.252306305281589 1161 17741380 SGTC_1923 st058458 19.1 µM 0.666554466815322 0.254495960732378 no 859 0.252528380906103 1299 3534982 SGTC_1431 4049-0260 9.09 µM 0.663716732801761 0.25542362629363 no 860 0.253435813899347 1233 3854841 SGTC_3329 9141233 27.5565 µM 0.662079801703897 0.255959547539261 no 861 0.253960039870405 1247 4909101 YNL103W MET4 SGTC_3266 9136860 49.47 µM 0.66128375025438 0.256220381795062 no 862 0.254215180245547 1188 4871271 YPR165W RHO1 SGTC_1733 st037357 54.9 µM 0.660484700814383 0.256482337669497 no 863 0.254471416603871 1210 1272339 YGL099W LSG1 SGTC_946 3434-1334 87.4 µM 0.660029946350506 0.256631484091609 no 864 0.25461730606636 1221 4047976 SGTC_2769 toremifene 3.73 µM 0.659881776838607 0.25668008919553 no 865 0.25466484968447 1269 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_65 0798-0905 34.986 µM 0.658898627312428 0.257002720137594 no 866 0.254980433701763 1408 3602145 SGTC_2462 5162487 171.77 µM 0.656812332480979 0.257688058059133 no 867 0.255650796738466 1220 2259986 SGTC_2567 aureobasidin a 60 nM 0.65670918401347 0.257721966437582 no 868 0.255683964007005 1324 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_704 1310-0270 142 µM 0.656404167896291 0.257822249067331 no 869 0.255782054725426 1233 5718033 SGTC_453 enantio-paf c16 10 µM 0.654051856249263 0.258596317456668 no 870 0.256539198577503 1255 13871343 A lipid and platelet activating factor SGTC_1365 1672-3266 55.4 µM 0.653978702687164 0.258620409166751 no 871 0.25656276338275 1264 6415873 SGTC_609 0986-0026 86.3 µM 0.653413456989168 0.258806601072545 no 872 0.256744882812103 1260 2848610 SGTC_2707 st078556 66.6 µM 0.653228184321559 0.25886764497155 no 873 0.256804591410548 1233 17250899 SGTC_124 0136-0217 7.121 µM 0.653136231015181 0.258897944642141 no 874 0.256834228271151 1383 3976905 SGTC_1873 rapamycin 2 nM 0.650312934116907 0.259829145592013 no 875 0.257745052015746 1265 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_406 estrone 100 µM 0.649539169481912 0.260084655809418 no 876 0.257994968613739 1300 5870 A steroid. SGTC_147 4466-0538 29.23 µM 0.648568571186608 0.260405346905351 no 877 0.258308637730309 1332 6742687 YHR072W ERG7 SGTC_2117 5521686 200 µM 0.647852406131264 0.260642102352837 no 878 0.258540208076874 1266 803312 SGTC_2369 9071472 200 µM 0.647097077936248 0.260891924650487 no 879 0.258784558176732 1302 17296037 SGTC_633 0437-0093 97.7 µM 0.646334425180235 0.261144294419569 no 880 0.259031398989272 1280 2831118 SGTC_1217 1183-1422 255 µM 0.646034381213046 0.26124361648478 no 881 0.259128544828284 1303 2849664 SGTC_670 4204-0025 119 µM 0.645869267694579 0.261298281471319 no 882 0.259182011997949 1287 719039 SGTC_1181 1222-0449 220 µM 0.645559813142875 0.261400750014966 no 883 0.259282235134701 1331 658318 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.644954523037251 0.261601237136308 no 884 0.259478328501677 1289 5282362 SGTC_1136 pergolide 1.05886 µM 0.642287048203001 0.262485710402569 no 885 0.260343411093471 1277 47811 A dopamine receptor agonist. SGTC_3008 9078912 71.4286 µM 0.64183434495132 0.262635968186357 no 886 0.260490373575514 1264 16648731 SGTC_2149 5554786 194.827 µM 0.640910896481246 0.262942608503732 no 887 0.260790287953183 1301 745063 YPR165W RHO1 SGTC_2327 6189656 200 µM 0.639407099889715 0.263442350642584 no 888 0.261279065704597 1329 5349088 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.638358940990666 0.263790961641086 no 889 0.26162002604183 1260 15053 SGTC_1125 tnp00248 1.32998 µM 0.6381839599667 0.263849182124475 no 890 0.261676968643791 1372 24207736 SGTC_312 4092-0653 6.84 µM 0.637402950612087 0.264109122968503 no 891 0.261931203465136 1299 1148278 SGTC_636 0kpi-0074 126 µM 0.636951227954031 0.264259527904138 no 892 0.262078306394768 1266 616434 SGTC_340 k038-0059 454 µM 0.636728332602495 0.264333758891565 no 893 0.262150907590975 1276 23733424 SGTC_2748 diazoxide 86.69 µM 0.634511398872687 0.265072643222103 no 894 0.262873565066344 1270 3019 A potassium channel activatior. SGTC_2957 9076800 11.52 µM 0.633552983875647 0.265392398949445 no 895 0.263186296226835 1244 16459615 SGTC_3222 9128301 49.47 µM 0.633111301350651 0.265539823230519 no 896 0.263330481344778 1312 4911358 SGTC_61 0978-8327 98.565 µM 0.632864947493517 0.265622068978534 no 897 0.263410919885895 1301 6150059 YHR072W ERG7 SGTC_127 0180-0333 59.125 µM 0.632566979312113 0.265721563535644 no 898 0.263508228101982 1257 771601 SGTC_642 0335-0876 158 µM 0.628345902030571 0.2671330501654 no 899 0.264888683900128 1317 6812350 SGTC_201 4262-0159 12.803 µM 0.626442563832973 0.267770743555264 no 900 0.265512349410228 1273 1341029 SGTC_815 1582-0027 36.9 µM 0.626276798353756 0.267826317817734 no 901 0.265566700912545 1336 3128206 SGTC_55 0767-0285 6.563 µM 0.625496608551017 0.268087960976151 no 902 0.26582258680065 1269 3116166 SGTC_2992 9074591 71.4286 µM 0.624903622229839 0.268286909905688 no 903 0.26601715742363 1320 17741321 SGTC_1346 1488-2224 62.4 µM 0.622789311167721 0.268996872442238 no 904 0.266711491654659 1305 3722427 SGTC_2980 9014342 25.29 µM 0.622523620056285 0.269086155266979 no 905 0.266798808667934 1304 2996599 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.621140079533243 0.269551320348829 no 906 0.26725373026147 1274 688803 SGTC_917 harmaline 728.087 nM 0.620627089227075 0.269723896989128 no 907 0.267422505890848 1332 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1632 st005650 90 µM 0.619917064943753 0.269962849699349 no 908 0.267656195061168 1322 2759605 SGTC_1415 3966-0071 78.1 µM 0.619019829536526 0.270264958194683 no 909 0.267951647872618 1300 2893185 SGTC_2305 7443522 69.23 µM 0.61890144459126 0.270304832257162 no 910 0.26799064339755 1294 5415886 SGTC_1784 st039334 36.3 µM 0.618709975264973 0.270369328606302 no 911 0.268053718671154 1387 3496984 SGTC_2357 9067248 200 µM 0.617376622875283 0.27081868089566 no 912 0.268493168829286 1326 9150235 SGTC_1680 diphenhydramine 100 µM 0.616785071679227 0.271018158520114 no 913 0.268688249916565 1340 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2333 9017922 200 µM 0.61677876512455 0.271020285555098 no 914 0.268690330068666 1381 3163164 SGTC_3172 9105863 49.47 µM 0.614203631768384 0.271889505578153 no 915 0.269540386883337 1300 2348785 SGTC_2128 5255449 168.493 µM 0.614079050019326 0.27193159250667 no 916 0.269581545725996 1306 736008 SGTC_694 1315-0438 43.2 µM 0.613317313197577 0.272188997316556 no 917 0.269833273902437 1318 6793154 SGTC_3076 9116187 49.47 µM 0.613174473690098 0.272237278879885 no 918 0.269880490613506 1313 27241210 SGTC_3218 9131285 49.47 µM 0.613083838255096 0.272267917012203 no 919 0.269910453006758 1376 17156417 SGTC_2778 tioconazole 65.09 nM 0.612892691066541 0.272332537454621 no 920 0.269973648179117 1283 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1288 0973-0013 65.5 µM 0.612625841175491 0.272422763179071 no 921 0.270061883804762 1361 4315430 SGTC_318 1488-0629 67.2 µM 0.612261034452366 0.272546133511497 no 922 0.270182532824683 1317 3662576 SGTC_2648 atorvastatin 78.68 µM 0.612213684968561 0.272562148192755 no 923 0.270198194240439 1331 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_339 3091-4833 71.4 µM 0.612020549545662 0.272627475860471 no 924 0.270262080825257 1308 3240077 SGTC_614 0462-0418 107 µM 0.611886397751542 0.272672857007999 no 925 0.270306460868423 1230 5188303 SGTC_2260 7964312 200 µM 0.611722462227416 0.27272831854685 no 926 0.270360698899391 1369 231951 SGTC_3118 9124250 49.47 µM 0.60951816509188 0.273474604374644 no 927 0.271090518027532 1272 1504786 SGTC_980 1473-0395 201 µM 0.608794872974589 0.273719701910033 no 928 0.27133020619979 1272 768876 SGTC_1860 st056228 74.6 µM 0.608544973156189 0.273804409167849 no 929 0.271413043797643 1295 688679 SGTC_403 arphamenine a 50 µM 0.608438976665813 0.273840342168653 no 930 0.271448183661507 1292 5487158 An arginine aminopeptidase inhibitor. SGTC_528 3492-0019 172 µM 0.608233609245228 0.273909968728133 no 931 0.27151627333835 1378 2869262 SGTC_1392 3455-1037 33.9 µM 0.606705304321396 0.274428390950674 no 932 0.272023250695543 1347 981132 SGTC_118 0083-0097 135.343 µM 0.60598489436053 0.274672931825385 no 933 0.272262392022521 1393 5207356 SGTC_3271 9137798 49.47 µM 0.605825681704937 0.274726990551752 no 934 0.272315257029292 1285 6498326 SGTC_525 k781-2675 26.7 µM 0.604684314826953 0.275114681369092 no 935 0.272694386009689 1367 3651118 YDL195W SEC31 SGTC_246 cycloheximide 667 µM 0.604432121509191 0.275200380806142 no 936 0.272778192635634 1245 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2152 5568786 200 µM 0.604343259337591 0.275230580764697 no 937 0.272807725561207 1308 5399883 SGTC_2889 9059656 51.95 µM 0.60254763484047 0.275841176101173 no 938 0.273404832561463 1391 3949838 SGTC_2730 imipramine 71.33 µM 0.602098192835146 0.275994111237255 no 939 0.273554388701403 1350 3696 A tricyclic antidepressant. SGTC_3202 9113761 49.47 µM 0.601111856382793 0.276329885532086 no 940 0.273882743479403 1434 4798415 SGTC_2847 9005661 71.43 µM 0.599643669143509 0.276830065095723 no 941 0.274371868649644 1258 2991449 SGTC_2482 5981709 142.65 µM 0.594046131234368 0.278741083016294 no 942 0.276240629474815 1359 877755 SGTC_581 0958-0271 211 µM 0.59342706692736 0.278952827350305 no 943 0.276447689564142 1343 4591145 SGTC_870 0573-2213 57.6 µM 0.590540617828846 0.27994113808606 no 944 0.277414131428842 1337 3916321 SGTC_660 4031-1742 102 µM 0.590374432901352 0.279998090912491 no 945 0.277469823768604 1291 6738706 SGTC_191 3914-0123 66.505 µM 0.589790515070836 0.2801982484836 no 946 0.27766555120607 1269 3144412 SGTC_1227 3909-8010 46.6 µM 0.586724183319241 0.281250473654745 no 947 0.278694481624656 1363 15982272 SGTC_2457 5731572 11.68 µM 0.586389175007688 0.281365548728516 no 948 0.278807008539593 1420 2865357 SGTC_1101 ebselen 5.29 µM 0.585573220057668 0.281645923609125 no 949 0.27908117449831 1413 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1685 st024049 53.0905 µM 0.585337746169704 0.281726861161255 no 950 0.279160319563126 1336 1941139 SGTC_2170 morpholine 200 µM 0.585329458741744 0.281729709936687 no 951 0.279163105247048 1423 121171 Reacts with secondary amines. SGTC_1343 1487-0095 224 µM 0.584577033422849 0.281988411451106 no 952 0.27941607705435 1367 4560101 YGL055W OLE1 SGTC_1219 1469-0211 33.1 µM 0.58305772401905 0.282511134250209 no 953 0.279927220981586 1349 6822282 SGTC_1234 0326-0494 15.5 µM 0.582127251468536 0.282831495899659 no 954 0.280240485210266 1432 1547813 SGTC_1270 0831-1170 17.3 µM 0.581714566128054 0.282973639276452 no 955 0.28037947922951 1324 6764716 SGTC_1328 1441-0025 69.2 µM 0.581517734355858 0.283041447154071 no 956 0.28044578468696 1282 4562601 SGTC_2511 berberine 10.47 µM 0.580994352028388 0.283221788520515 no 957 0.280622130054896 1369 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2968 9090663 33.37 µM 0.580670065420276 0.283333555307652 no 958 0.280731420192008 1380 25236811 SGTC_2755 lomerizine 42.69 µM 0.579820839866686 0.283626344753024 no 959 0.281017721240683 1360 3949 A calcium channel blocker. SGTC_1152 3909-8331 15.9 µM 0.579578091417754 0.283710064322813 no 960 0.281099585413722 1344 16001939 SGTC_3188 9110789 49.47 µM 0.579558375920296 0.283716864362552 no 961 0.281106234748375 1401 849217 SGTC_1921 5740136 50 µM 0.578973039521354 0.283918787326123 no 962 0.281303682460415 1448 1774243 SGTC_3044 9093193 49.47 µM 0.577951697401894 0.284271283400084 no 963 0.281648365382073 1329 25236277 SGTC_120 rhodamine 6G 52.259 µM 0.577745720716872 0.284342397528757 no 964 0.281717903139906 1365 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_470 aa-861 153 µM 0.57697379170752 0.284608984170639 no 965 0.281978580088333 1323 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2659 sanguinarine 24.21 µM 0.575151994072838 0.285238617003368 no 966 0.282594253194016 1327 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_34 0469-0683 81.75 µM 0.573372094030405 0.285854409826252 no 967 0.283196390448304 1415 3690923 SGTC_768 0384-0033 77.3 µM 0.572439354434525 0.286177362396468 no 968 0.283512180315704 1353 3965305 YMR134W ERG29 SGTC_2256 7954252 200 µM 0.572097972505715 0.28629560607952 no 969 0.283627801318901 1324 2972920 SGTC_681 1642-0006 26.6 µM 0.57145060617503 0.286519896563761 no 970 0.28384711671733 1367 4446530 SGTC_1308 1187-1617 41.4 µM 0.571235325393624 0.286594502521813 no 971 0.28392006773385 1374 2882570 SGTC_2665 lovastatin 100 µM 0.570255635827433 0.286934132098454 no 972 0.284252163038627 1357 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2477 5967686 25.23 µM 0.56997018692323 0.287033124704093 no 973 0.284348959471412 1339 776118 SGTC_306 1672-3436 11.6 µM 0.569783810770927 0.287097767979232 no 974 0.284412168586997 1405 6797378 SGTC_2245 6637752 200 µM 0.568145077062536 0.287666447953495 no 975 0.284968230818664 1416 681890 SGTC_805 3852-0218 479 µM 0.567656889987595 0.287835963456424 no 976 0.285133984755296 1339 6615355 SGTC_629 3448-6466 76.7 µM 0.567649205247318 0.28783863224222 no 977 0.285136594319031 1371 573744 SGTC_1117 retinoic acid 1.10837 µM 0.564347274026157 0.288986419324147 no 978 0.286258907247106 1486 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1799 st045822 46.1415 µM 0.563387725287515 0.289320372208751 no 979 0.286585446861586 1385 3674992 SGTC_539 4859-0462 2.54 µM 0.563159866772406 0.289399700715125 no 980 0.286663014295204 1418 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2171 5739187 198.077 µM 0.56280048800787 0.289524838508732 no 981 0.286785373988142 1332 2262761 SGTC_2017 5132927 60.65 µM 0.562125576257328 0.289759915382217 no 982 0.287015231835975 1353 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_202 3594-0513 34.79 µM 0.561920086792797 0.289831506699609 no 983 0.287085233666995 1385 708429 SGTC_510 ag-490 170 µM 0.561517102407746 0.289971928169003 no 984 0.287222537384314 1495 5328779 SGTC_2692 st077426 47.7 µM 0.561201297180455 0.29008199401256 no 985 0.287330159379447 1396 25238571 SGTC_742 0kpi-0133 140 µM 0.56062333573584 0.29028347840206 no 986 0.287527169934353 1469 2728852 SGTC_543 3844-1095 191 µM 0.560152993718767 0.290447493709752 no 987 0.287687543220902 1452 4230703 SGTC_2686 alizarin 95.37 µM 0.558851457761328 0.29090158475924 no 988 0.288131550252726 1363 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2014 4013930 200 µM 0.555342427911933 0.292127495479051 no 989 0.289330231766482 1365 64556 SGTC_1355 1499-0035 1.68 µM 0.554523450413525 0.292413958209812 no 990 0.289610330671492 1389 1548538 SGTC_1045 1348-1485 165 µM 0.554249161531384 0.292509928422568 no 991 0.289704168798232 1394 6810614 SGTC_503 tyrphostin 8 294 µM 0.554220077543957 0.292520105400473 no 992 0.289714119680551 1400 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1709 st033179 39.1045 µM 0.554141246168937 0.292547690656069 no 993 0.289741092089194 1385 573381 SGTC_1802 st050112 57.9 µM 0.552283596184603 0.293198082815376 no 994 0.290377033790256 1377 4662563 SGTC_1934 st074720 32.6 µM 0.552239206787903 0.29321363243164 no 995 0.290392237899964 1370 17250992 SGTC_443 clozapine 122 µM 0.549544735164109 0.294158221591067 no 996 0.291315836609631 1370 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1900 st060200 72.8 µM 0.549423735749618 0.294200672797369 no 997 0.291357344382615 1416 688945 SGTC_1521 st012942 49.4 µM 0.549184155682489 0.2942847349653 no 998 0.291439538334658 1547 24207259 SGTC_2644 guaiazulene 100 µM 0.548934879421446 0.294372211039847 no 999 0.291525070289899 1419 3515 A coloring agent. SGTC_2948 9070189 9.45 µM 0.548813088455809 0.29441495431486 no 1000 0.291566863601618 1407 6473636 YDL196W YDL196W SGTC_3047 9092122 49.47 µM 0.547148798264722 0.294999333885308 no 1001 0.292138254652969 1369 17173831 SGTC_2389 9091542 195.52 µM 0.544143203128343 0.296056035399329 no 1002 0.293171466264419 1400 3626624 YOL127W RPL25 SGTC_1904 st060225 78 µM 0.542865451181305 0.296505790696126 no 1003 0.293611222456088 1376 66595 SGTC_3013 9080133 71.4286 µM 0.54146708401027 0.296998359784355 no 1004 0.294092839752075 1486 17050193 SGTC_607 4491-0986 66.8 µM 0.540955150990217 0.297178779636443 no 1005 0.294269247932801 1496 698981 YDR232W HEM1 SGTC_146 3448-8650 53.125 µM 0.540721187332823 0.29726125180484 no 1006 0.294349886278993 1470 2891488 YIL048W NEO1 SGTC_1034 k072-0165 12.7 µM 0.540474993595437 0.297348046367282 no 1007 0.2944347508831 1525 5835461 SGTC_727 3032-0951 202 µM 0.539726022189535 0.297612164231597 no 1008 0.294692995684412 1435 3652836 SGTC_1447 4239-0816 81.9 µM 0.539560725003456 0.29767046918124 no 1009 0.294750004103614 1369 1341554 SGTC_885 0865-0106 16.8 µM 0.537760453522567 0.298305812605156 no 1010 0.295371218652088 1368 2793380 SGTC_985 1493-0307 8.71 µM 0.537069574984269 0.298549798058507 no 1011 0.295609777980418 1427 3278274 SGTC_1441 4106-0040 13 µM 0.536369897146511 0.298796983477525 no 1012 0.295851465925774 1412 2904180 SGTC_2436 5633522 8.09 µM 0.535062959038546 0.299258953551819 no 1013 0.296303161176605 1478 5724242 SGTC_955 1216-0110 33 µM 0.532374590302897 0.300210242295008 no 1014 0.297233290149344 1376 3619719 SGTC_791 1348-1292 225 µM 0.531840287813139 0.300399469858954 no 1015 0.297418308392842 1434 5437054 SGTC_500 h-89 112 µM 0.53140343489706 0.300554224895376 no 1016 0.297569620875686 1552 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3230 9131665 49.47 µM 0.529811250689993 0.301118560206072 no 1017 0.29812140196068 1421 15943720 SGTC_3022 9087993 49.47 µM 0.52929951885132 0.301300040275185 no 1018 0.29829884466095 1500 17173644 SGTC_2670 beta-carotene 100 µM 0.528858803212704 0.301456374692926 no 1019 0.298451701064029 1392 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_769 0302-0231 76 µM 0.527923232595224 0.301788369242375 no 1020 0.298776309465026 1451 571869 YER009W NTF2 SGTC_2024 5144227 134 µM 0.527588633293952 0.301907144308085 no 1021 0.29889244199066 1490 3475211 SGTC_724 3910-0327 137 µM 0.526258548822942 0.302379501289105 no 1022 0.299354289564263 1415 2885483 SGTC_3126 9127922 49.47 µM 0.525871693119652 0.30251694874168 no 1023 0.299488678885563 1457 45595682 SGTC_1988 st071872 53.4 µM 0.525854706681689 0.302522984560487 no 1024 0.299494580409861 1478 16414116 SGTC_1290 0986-0249 10.2 µM 0.525741148074565 0.30256333691297 no 1025 0.2995340349372 1417 53329 SGTC_2932 9016711 44.54 µM 0.523086091185799 0.30350748174209 no 1026 0.300457172066048 1539 7117328 SGTC_2206 7254556 146.969 µM 0.52242294459002 0.303743503540286 no 1027 0.3006879420297 1477 4398905 SGTC_923 1900-2434 73.3 µM 0.522102503834626 0.30385758157732 no 1028 0.300799481630932 1404 5910570 SGTC_1453 4237-0541 195 µM 0.52143005839707 0.304097036628517 no 1029 0.301033608326168 1463 739892 SGTC_2967 9089538 49.85 µM 0.519101618376343 0.304926833467458 no 1030 0.301844939914483 1571 728216 SGTC_2939 9044578 71.43 µM 0.518959638077569 0.304977464162118 no 1031 0.301894443909643 1407 2653634 SGTC_1155 4088-0394 48.2 µM 0.518836162405301 0.305021499074741 no 1032 0.301937498898178 1415 2326248 SGTC_1814 st052110 31.539 µM 0.517954700832289 0.305335935161177 no 1033 0.30224493766635 1517 674163 SGTC_1220 1838-0075 193 µM 0.517377995935614 0.305541735836222 no 1034 0.302446158488759 1450 5529645 SGTC_1800 st050079 29.0735 µM 0.516143548672477 0.305982462408878 no 1035 0.302877077068017 1407 3645560 SGTC_715 0868-0130 184 µM 0.514143654869761 0.306697067629369 no 1036 0.30357577900557 1603 2876258 SGTC_2751 anetholtrithion 17.25 µM 0.514066304525019 0.306724721365231 no 1037 0.30360281730979 1533 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1662 st014054 52 µM 0.513168545423732 0.307045762157829 no 1038 0.303916713329421 1444 2838777 SGTC_816 0325-0417 81.3 µM 0.511470571612011 0.307653366145285 no 1039 0.304510794913529 1445 68101 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.511243679724395 0.3077345973029 no 1040 0.304590218235145 1498 279621 SGTC_1960 st011366 51.8 µM 0.510785859539755 0.30789853341605 no 1041 0.304750505868541 1460 3972846 SGTC_2431 5490079 200 µM 0.510149634848445 0.308126416233698 no 1042 0.304973317025526 1444 5722345 SGTC_2324 6149169 200 µM 0.509302837959209 0.308429836518602 no 1043 0.305269984498619 1446 2888231 SGTC_375 3970-0961 9.27 µM 0.50886747641425 0.308585884185355 no 1044 0.305422559217515 1487 2898222 SGTC_1748 st037455 53.6035 µM 0.507192476833155 0.309186580477978 no 1045 0.306009886576424 1512 580690 SGTC_2173 5763948 167 µM 0.506964240666631 0.309268471165746 no 1046 0.306089954726276 1467 2867177 SGTC_3305 9127027 53.8275 µM 0.506593805050821 0.309401402905163 no 1047 0.306219927971939 1466 41905295 SGTC_160 3453-0671 289.699 µM 0.506546289105534 0.309418455925484 no 1048 0.306236601464814 1389 5322268 SGTC_2060 5238662 140 µM 0.505884767833701 0.309655912230459 no 1049 0.306468773008902 1454 790130 SGTC_623 k072-0108 16.9 µM 0.503848532357891 0.310387327380578 no 1050 0.307183910055548 1490 5382803 SGTC_2418 pentamidine 31.67 µM 0.503830696443809 0.310393737354958 no 1051 0.307190177372583 1418 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3324 9138759 60.749 µM 0.5022088669943 0.310976840336178 no 1052 0.30776030315957 1491 45595710 SGTC_1902 st060212 70.5 µM 0.501365531538014 0.311280235957584 no 1053 0.30805694665281 1468 688944 SGTC_1052 3253-3998 198 µM 0.501008944933077 0.311408558984157 no 1054 0.308182413841589 1431 5450317 SGTC_2201 6605497 169.863 µM 0.499840406773994 0.311829235459817 no 1055 0.308593728208847 1524 670741 SGTC_1026 k007-1105 30.6 µM 0.499257455971304 0.312039190983777 no 1056 0.308799011243772 1462 7066794 SGTC_840 0245-0196 390 µM 0.496880283503558 0.312895985034377 no 1057 0.309636738026067 1555 3827528 SGTC_125 0133-0007 11.75 µM 0.495913101243775 0.313244872181853 no 1058 0.309977861176356 1583 26541 SGTC_1363 1636-0063 10.4 µM 0.495642291047444 0.313342590261636 no 1059 0.310073404700651 1491 6072185 SGTC_386 1509-0011 3.07 µM 0.495464727381794 0.3134066687463 no 1060 0.310136057229791 1481 3107280 SGTC_1546 5-methoxyflavanone 78.7 µM 0.494987944077198 0.313578756313586 no 1061 0.310304315310853 1551 147795 SGTC_205 1486-1330 71.903 µM 0.494849292281623 0.313628808154853 no 1062 0.310353253348949 1505 4118834 SGTC_638 3970-0837 4.09 µM 0.492410949677854 0.314509584261551 no 1063 0.311214430090408 1461 4118451 YLR208W SEC13 SGTC_1477 0139-0234 16 µM 0.491253283989577 0.31492812560535 no 1064 0.311623658282701 1528 620880 SGTC_1384 3089-0840 101 µM 0.488996155282527 0.315744849189298 no 1065 0.312422209403005 1580 1069836 SGTC_377 3970-0964 33.1 µM 0.488207983947494 0.316030254890213 no 1066 0.312701264977115 1536 16481235 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.488109252660726 0.316066014332503 no 1067 0.312736228801323 1536 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1966 st070145 16.1 µM 0.485965379399857 0.316842926776489 no 1068 0.313495856204551 1448 3748532 SGTC_3049 9092223 49.47 µM 0.485391000580468 0.317051211814443 no 1069 0.31369950744943 1499 8623917 SGTC_531 3788-1495 174 µM 0.484551665220587 0.31735568139666 no 1070 0.313997203555498 1489 2896655 SGTC_211 3455-0679 143.504 µM 0.483922213420776 0.317584096686599 no 1071 0.314220537470679 1511 748649 SGTC_1128 3448-9350 235 µM 0.482847038336915 0.317974416537534 no 1072 0.314602174464032 1492 619386 SGTC_2829 7992743 58.44 µM 0.482718623673613 0.318021048329725 no 1073 0.314647768933256 1605 16462845 SGTC_1359 1582-0056 520 nM 0.482530969687687 0.318089197151339 no 1074 0.314714401795645 1547 3661189 SGTC_1364 1653-0028 37.6 µM 0.480665855842731 0.318766870403499 no 1075 0.315377000949573 1521 5718652 SGTC_2855 9016525 58.44 µM 0.479979701557656 0.319016331450311 no 1076 0.315620913307911 1471 43811474 SGTC_2360 9040895 200 µM 0.478842890607831 0.319429815494465 no 1077 0.316025200719076 1473 4914414 SGTC_995 3931-2021 34.6 µM 0.478712436755175 0.319477278910268 no 1078 0.31607160849294 1548 730143 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.47869287043388 0.31948439803862 no 1079 0.316078569284087 1516 6857784 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.478637258431338 0.319504632608326 no 1080 0.316098353815602 1470 61125 An anti-inflammatory. SGTC_373 0844-0104 25.9 µM 0.477059341594895 0.320078985459728 no 1081 0.316659932943149 1591 5375804 SGTC_599 1935-0052 86.5 µM 0.476152314591479 0.320409333572094 no 1082 0.316982934487512 1486 9557311 SGTC_1977 st070720 65.3 µM 0.473084115911868 0.321527855535866 no 1083 0.318076584325574 1508 682188 SGTC_2197 6588183 93.1375 µM 0.472774451735466 0.321640834802509 no 1084 0.318187051544794 1500 884136 SGTC_1808 st050063 61.5 µM 0.468234339810393 0.323299159014113 no 1085 0.319808508774937 1580 4011993 SGTC_1830 st055982 50.3 µM 0.466907641866314 0.323784415074935 no 1086 0.320282978816416 1592 455313 An antimicrobial agent. SGTC_1668 st014914 51.6 µM 0.466760311555436 0.323838321448456 no 1087 0.320335687043972 1527 2839556 SGTC_717 1532-0246 73.2 µM 0.46645988326746 0.323948255964184 no 1088 0.320443178144193 1503 9561992 SGTC_2916 7875993 68.79 µM 0.466103848380053 0.324078558263256 no 1089 0.320570584393917 1656 1299250 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.464858661420198 0.324534443497081 no 1090 0.321016337837927 1529 97141 SGTC_90 0870-0863 4.608 µM 0.464845392247929 0.324539302996247 no 1091 0.321021089342089 1494 1738164 SGTC_449 xestospongin c 11.1929 µM 0.464123080562397 0.324803876460902 no 1092 0.321279783211171 1591 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2537 larixol 68.93 µM 0.461817522853359 0.325648963456046 no 1093 0.322106091904975 1597 6708759 SGTC_2381 9035592 200 µM 0.461452916830857 0.32578268963436 no 1094 0.32223684689993 1456 4749657 SGTC_468 gf-109203x 121 µM 0.46108654224852 0.325917087048212 no 1095 0.322368258297232 1575 2396 A protein kinase C inhibitor. SGTC_2445 5742597 35.57 µM 0.460506945770518 0.326129746977705 no 1096 0.322576193554882 1495 1774255 SGTC_1625 st003711 30.1 µM 0.457839822316503 0.327109070127799 no 1097 0.32353376175631 1614 24207034 YER133W GLC7 SGTC_2106 5357045 167.29 µM 0.457212895330975 0.327339440455696 no 1098 0.323759015237843 1611 668842 SGTC_2332 7982454 138.89 µM 0.452596819219292 0.329037682142414 no 1099 0.325419544801646 1525 2981748 SGTC_1150 3909-7983 10.9 µM 0.451814855601466 0.329325715464178 no 1100 0.32570118337715 1514 23965914 SGTC_3024 9090631 49.47 µM 0.451306998225394 0.329512837076757 no 1101 0.325884150865044 1603 25236383 SGTC_2238 6671620 73.2395 µM 0.450745358137984 0.329719824813595 no 1102 0.326086543668454 1469 729941 SGTC_2146 5545642 200 µM 0.450399940317449 0.329847151560942 no 1103 0.326211043998267 1551 825326 SGTC_2868 9035608 32.47 µM 0.450297526334276 0.32988490684719 no 1104 0.326247961204404 1513 6462614 SGTC_2636 apigenin dimethyl ether 100 µM 0.449806836578945 0.3300658254436 no 1105 0.326424863935731 1565 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2262 9014885 67.46 µM 0.449787961187132 0.330072785644096 no 1106 0.326431669643718 1591 6457424 SGTC_1478 0453-0656 35.7 µM 0.449205846783461 0.330287466105556 no 1107 0.326641585070603 1578 5258496 SGTC_2977 9011197 71.43 µM 0.449125697184724 0.330317029196871 no 1108 0.326670492001618 1613 2704722 SGTC_687 k029-0044 34.9 µM 0.448822255680682 0.330428962856102 no 1109 0.326779941309678 1679 5829338 SGTC_3072 9116419 49.47 µM 0.448370188724924 0.330595749686469 no 1110 0.326943026462733 1498 17170162 SGTC_245 methotrexate 289.6 µM 0.448055667495164 0.330711809867263 no 1111 0.327056510890374 1582 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_119 0121-0043 24.815 µM 0.444016619003454 0.332203685816995 no 1112 0.328515284288185 1580 1092378 SGTC_3192 9110362 49.47 µM 0.442854471740308 0.332633434690206 no 1113 0.328935500152544 1602 16649480 SGTC_3142 9086498 49.47 µM 0.441556454591822 0.333113686831474 no 1114 0.329405100347252 1581 25236367 SGTC_2448 5185112 27.17 µM 0.44154616336769 0.333117495566833 no 1115 0.329408824611048 1544 5718189 SGTC_1197 1601-0112 267 µM 0.441506339152878 0.33313223449023 no 1116 0.329423236649935 1527 7350313 SGTC_2125 5246583 200 µM 0.441443120303175 0.333155632286443 no 1117 0.329446115525253 1711 835267 SGTC_671 0560-0003 407 µM 0.440022216139389 0.333681691336072 no 1118 0.32996050846089 1613 3238678 SGTC_448 monastrol 171 µM 0.439453722412001 0.333892255533934 no 1119 0.330166403597713 1601 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2040 5100729 123 µM 0.435925089849842 0.33520039240312 no 1120 0.331445540376684 1605 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1638 st008370 60.6 µM 0.435515479079291 0.335352373493555 no 1121 0.331594152950912 1525 24207134 SGTC_2821 7996764 71.43 µM 0.434959628878803 0.335558658042036 no 1122 0.331795865654695 1618 2987135 SGTC_998 3996-0085 177 µM 0.430445341051899 0.337235811109151 no 1123 0.333435859511429 1716 715391 SGTC_1688 st021091 57.6 µM 0.429767324293207 0.337487989265411 no 1124 0.333682452147377 1685 3656366 SGTC_2650 prasterone 100 µM 0.429589179639593 0.337554259610526 no 1125 0.333747254742233 1577 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1193 1488-0126 41.5 µM 0.428451953937578 0.337977429644216 no 1126 0.334161053217305 1573 1384710 SGTC_1579 chlormadinone acetate 49.4 µM 0.426729682881038 0.338618689230506 no 1127 0.334788114009001 1692 45114258 A steroidal progestin. SGTC_1863 st057641 20.1 µM 0.426395993782319 0.338742987129171 no 1128 0.334909660065014 1610 3921635 SGTC_2729 fluphenazine 10.66 µM 0.425764547868679 0.338978246345646 no 1129 0.335139711185057 1519 3372 An atypical antipsychotic. SGTC_2384 9036245 200 µM 0.422482464697467 0.340202069345268 no 1130 0.336336448630122 1681 6462766 SGTC_1806 st050005 60.3 µM 0.422188747676519 0.3403116728768 no 1131 0.33644362701254 1562 5194765 SGTC_261 5-fluorouridine 15.376 µM 0.421961622145685 0.340396436358648 no 1132 0.336526515037334 1665 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_232 clozapine 119 µM 0.420346234853222 0.340999532968186 no 1133 0.337116269377793 1613 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2587 piperic acid 92.2 µM 0.419497126078747 0.34131670650013 no 1134 0.33742642731171 1548 5370536 SGTC_1938 st074717 56.4 µM 0.4186469315968 0.341634397930354 no 1135 0.337737092536537 1538 17250979 SGTC_1844 rapamycin 4 nM 0.417957845531075 0.341891970465389 no 1136 0.337988969110966 1599 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1242 0402-0103 60.1 µM 0.417011824676515 0.342245702183373 no 1137 0.338334879329033 1557 432868 SGTC_1245 0418-0076 17.2 µM 0.416905949000388 0.342285299344524 no 1138 0.338373601008991 1631 6790114 SGTC_2688 kanamycin b 96.69 µM 0.416586455913792 0.34240479923738 no 1139 0.338490458877824 1592 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2249 haloperidol 116.36 µM 0.415770508943136 0.342710059194459 no 1140 0.338788970403824 1654 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_650 1328-0195 38 µM 0.414216314065497 0.343291794621324 no 1141 0.339357847575964 1669 2780821 SGTC_204 PMA1.184 62.41 µM 0.414063228718316 0.34334911461516 no 1142 0.339413900772694 1605 2252213 YGL008C PMA1 SGTC_1167 k781-0610 148 µM 0.412982116547997 0.343754019709663 no 1143 0.339809858122766 1621 4525169 SGTC_667 1498-1044 59 µM 0.410364469759075 0.344735139520964 no 1144 0.340769302938779 1646 6739982 SGTC_1980 st071811 45.7 µM 0.407448874598815 0.345829163660223 no 1145 0.341839168299148 1686 4974850 SGTC_2295 7971645 200 µM 0.407234039069649 0.345909827870202 no 1146 0.341918051689359 1674 2978226 YKL099C UTP11 SGTC_1519 esterone 74 µM 0.407172994090808 0.345932749680083 no 1147 0.341940467466895 1527 698 A steroid. SGTC_2794 7785382 27.27 µM 0.406911121198971 0.346031086869683 no 1148 0.342036633776704 1722 2205081 SGTC_3177 9107506 49.47 µM 0.406169315544207 0.34630970234636 no 1149 0.34230909907523 1692 8897194 SGTC_1035 k081-0041 55.2 µM 0.405711777313148 0.346481591046571 no 1150 0.342477193864523 1713 731709 SGTC_1602 st001878 87.6 µM 0.403904375207435 0.3471609076248 no 1151 0.343141519441583 1670 595405 YLR310C CDC25 SGTC_1368 1852-0141 284 µM 0.401802164627935 0.34795164679189 no 1152 0.343914814484241 1625 2838987 SGTC_3184 9108758 49.47 µM 0.401102162387388 0.348215097209828 no 1153 0.344172454433748 1628 902885 SGTC_3157 9099274 49.47 µM 0.400588795239488 0.348408352864314 no 1154 0.344361448229108 1725 17217662 SGTC_1039 k821-0043 94 µM 0.4004380619285 0.348465103482638 no 1155 0.344416947400219 1723 15992768 SGTC_3062 9077494 49.47 µM 0.399137539226022 0.34895488696698 no 1156 0.344895931693537 1675 16459633 SGTC_357 1325-0123 420 µM 0.398669062665643 0.349131379352434 no 1157 0.345068533217243 1729 1098503 SGTC_3005 9076496 71.4286 µM 0.398646426024307 0.34913990823636 no 1158 0.345076874085844 1676 21368410 SGTC_765 1319-0117 244 µM 0.398630589933478 0.349145874899168 no 1159 0.345082709216759 1559 3487746 YGL099W LSG1 SGTC_1959 st077091 55.8 µM 0.397632992535935 0.349521821009925 no 1160 0.345450368539491 1606 821356 YKL052C ASK1 SGTC_155 k072-0202 43.6 µM 0.397200744800253 0.349684760100495 no 1161 0.345609716503286 1647 5857737 SGTC_991 3996-0057 64.7 µM 0.396999509124966 0.349760626876956 no 1162 0.345683911294247 1639 715343 SGTC_2937 9044753 11.33 µM 0.396858996055389 0.349813604508754 no 1163 0.34573572141734 1582 6465530 YGL099W LSG1 SGTC_2386 9075165 157.42 µM 0.396199345250607 0.350062351673543 no 1164 0.34597898714401 1645 16452277 SGTC_920 mycophenolic acid 780.421 nM 0.395723061605238 0.35024199308245 no 1165 0.346154670347315 1598 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_38 0929-0051 58.268 µM 0.39485870158451 0.350568092054954 no 1166 0.346473584952839 1786 1379719 SGTC_504 lovastatin 124 µM 0.394193595522022 0.350819093060554 no 1167 0.346719056865183 1581 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_976 1348-1067 47.6 µM 0.3939989384087 0.350892566045537 no 1168 0.346790911502293 1626 5310671 YGL099W LSG1 SGTC_1102 cgs 12066b 26.1 µM 0.393735734168804 0.350991920889297 no 1169 0.346888078005359 1655 6438352 A 5-HT1B full agonist. SGTC_3252 9135871 49.47 µM 0.392996989307604 0.351270838132119 no 1170 0.34716085252347 1681 17682838 SGTC_2391 6285546 200 µM 0.390257532221683 0.352305833851098 no 1171 0.348173061454675 1605 846083 SGTC_343 4130-2827 29.8 µM 0.388704467095791 0.352893084977719 no 1172 0.348747388738553 1616 1118244 SGTC_3330 9141424 71.43 µM 0.386665626681043 0.353664551513826 no 1173 0.34950188322673 1742 27261020 SGTC_972 1319-0219 195 µM 0.385546366636027 0.354088318585429 no 1174 0.349916330422516 1612 23903702 SGTC_486 niguldipine 82 µM 0.385535672573161 0.35409236837574 no 1175 0.349920291156046 1669 1236 A calcium channel blocker. SGTC_219 mitoxanthrone 164.414 µM 0.38399358838764 0.354676520834002 no 1176 0.350491599813517 1720 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1833 st055984 71 µM 0.383718174503332 0.354780885596804 no 1177 0.350593670318041 1664 676288 SGTC_1272 0839-0021 27 µM 0.380737959763918 0.355910897591681 no 1178 0.351698849371605 1678 5027250 SGTC_953 1188-0045 9.7 µM 0.380653598778094 0.355942903346209 no 1179 0.351730151993787 1705 6144426 SGTC_2780 5215298 71.43 µM 0.380384233048275 0.356045104934022 no 1180 0.351830108403504 1799 2834131 SGTC_1522 st012842 45.6 µM 0.379960630138509 0.356205847452474 no 1181 0.35198731996196 1554 3491067 YOR116C RPO31 SGTC_2429 5902844 64.44 µM 0.379783721427324 0.356272985700194 no 1182 0.35205298350521 1779 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3250 9135583 49.47 µM 0.378707451718396 0.356681534461405 no 1183 0.352452559585629 1744 7699353 SGTC_233 rapamycin 362 pM 0.378654848894152 0.35670150655562 no 1184 0.35247209309795 1687 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2154 5570129 200 µM 0.376090759369112 0.357675508293729 no 1185 0.353424711921936 1653 673366 SGTC_865 0488-0499 301 µM 0.375568612966824 0.35787396607001 no 1186 0.353618814251747 1699 9634651 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.37532376230387 0.357967042320377 no 1187 0.353709847975675 1694 688788 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.372035210361562 0.359217951528244 no 1188 0.354933316929423 1693 616764 SGTC_905 2-aminofluorene 215 µM 0.371962367649721 0.359245676806659 no 1189 0.354960434243002 1647 1539 An established DNA mutagen. YPR165W RHO1 SGTC_699 0375-0592 111 µM 0.371369149028261 0.359471494331298 no 1190 0.355181300365522 1754 762578 SGTC_566 0958-0068 16.5 µM 0.37101997149647 0.359604436926758 no 1191 0.355311328291367 1707 6815365 SGTC_1256 0570-0116 285 µM 0.370616374049465 0.35975812002345 no 1192 0.355461642280207 1610 410638 SGTC_159 3970-0959 50 µM 0.369373699459722 0.360231451854757 no 1193 0.35592459943457 1720 6615653 SGTC_1654 st012436 41.8 µM 0.36887992465685 0.360419589059562 no 1194 0.35610861377744 1746 4323132 SGTC_696 1560-0013 611 µM 0.366809809142083 0.36120870824224 no 1195 0.356880445135678 1743 1650269 SGTC_198 3454-2873 16.191 µM 0.365348331125077 0.361766173516413 no 1196 0.357425702542893 1699 710957 SGTC_3183 9108214 49.47 µM 0.365289212476751 0.361788729880892 no 1197 0.357447765035008 1704 4974831 SGTC_3069 9117009 49.47 µM 0.364558163435876 0.362067696902994 no 1198 0.357720624625779 1701 41904981 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.364327402756373 0.362155769995842 no 1199 0.35780676974852 1647 688664 SGTC_1159 4092-0538 61.2 µM 0.363562286141264 0.362447839819342 no 1200 0.358092446742528 1710 717301 SGTC_3235 9132602 49.47 µM 0.362606678712318 0.3628127386139 no 1201 0.358449360241496 1712 4912240 SGTC_2248 tofa 1.1 µM 0.362217636111959 0.36296133028152 no 1202 0.358594700706631 1701 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2323 6148992 148.28 µM 0.362088222314942 0.363010763406761 no 1203 0.358643052296 1644 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1287 0971-0001 34.6 µM 0.361086353533498 0.363393531654725 no 1204 0.35901744717382 1718 4665869 SGTC_1304 1165-0502 251 µM 0.359426571263118 0.364027958657108 no 1205 0.359637999988831 1705 767425 SGTC_3055 9094636 49.47 µM 0.358714829609891 0.364300125610447 no 1206 0.359904216668772 1748 25236176 SGTC_701 4424-0219 185 µM 0.358569731609017 0.364355618866068 no 1207 0.359958496824587 1800 2911779 SGTC_3344 9148862 3.898 µM 0.358548484216869 0.364363745246802 no 1208 0.35996644556371 1771 4905352 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.357852486493156 0.364629973603747 no 1209 0.360226854712976 1685 3256 An antibiotic and ribosome inhibitor. SGTC_2279 7948423 32.93 µM 0.354438938320453 0.365936644370804 no 1210 0.361504978778113 1859 1247112 SGTC_1241 0364-0022 50.8 µM 0.351282288622955 0.367146362947264 no 1211 0.362688290486312 1734 4563895 SGTC_1805 st050013 60.3 µM 0.349988483981072 0.367642568057695 no 1212 0.363173670108027 1751 4037144 SGTC_1129 3453-1384 223 µM 0.349852594317091 0.367694697843643 no 1213 0.36322466281064 1744 1084452 SGTC_713 1488-1073 324 µM 0.346584621553668 0.368949084714173 no 1214 0.364451700422717 1786 3312542 SGTC_1310 1188-0297 994 nM 0.344636009772948 0.369697710592082 no 1215 0.365184015293666 1731 1588352 SGTC_3166 9102297 49.47 µM 0.344069255550616 0.369915541509424 no 1216 0.36539710171697 1671 25237072 SGTC_1104 tacrolimus 29.8 µM 0.343086827062533 0.370293234906643 no 1217 0.365766570425759 1738 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1677 st019204 53.9 µM 0.342842752506291 0.370387088476069 no 1218 0.365858380568424 1640 3945625 SGTC_3328 9140624 29.0385 µM 0.342830334147657 0.370391863892487 no 1219 0.365863052015695 1826 4904392 SGTC_506 n9-isopropylolomoucine 153 µM 0.342222348432075 0.370625686109615 no 1220 0.366091783942731 1885 6610355 SGTC_3317 9138495 8.753 µM 0.34164027928509 0.370849585987005 no 1221 0.366310810325661 1711 17020139 SGTC_838 0109-0203 71.4 µM 0.3415526439535 0.370883299758257 no 1222 0.366343790336325 1704 759422 SGTC_230 MPP+ 141.667 µM 0.341406004692225 0.370939714867263 no 1223 0.366398977642563 1672 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2498 4'-Methoxychalcone 54.63 µM 0.339370920138668 0.371722939237104 no 1224 0.367165161227638 1630 641818 YHR062C RPP1 SGTC_94 0334-0113 514.748 µM 0.338314654379137 0.372129664215129 no 1225 0.367563040772045 1648 6795178 SGTC_2383 9036125 200 µM 0.335465309566949 0.373227541546165 no 1226 0.368637054538917 1752 79580 SGTC_1606 st000094 49.2 µM 0.335363261858187 0.373266880574238 no 1227 0.3686755388453 1878 1242210 SGTC_365 0121-0052 13.6 µM 0.335075270453165 0.373377907358213 no 1228 0.36878415347623 1768 3101739 SGTC_1751 st044839 27.194 µM 0.334025388113196 0.373782748185326 no 1229 0.369180200457702 1771 5291326 SGTC_1718 roemerine 11.9335 µM 0.332190341669738 0.374490687201086 no 1230 0.369872768152278 1730 235224 An aporphine alkaloid with mutagenic activity. SGTC_574 1315-0397 40 µM 0.330486362663659 0.375148441086321 no 1231 0.37051624766819 1729 6794277 SGTC_656 4090-1979 187 µM 0.329266180359965 0.375619667634703 no 1232 0.370977252161617 1857 22330961 SGTC_2747 doxorubicin 7.63 µM 0.328921977502556 0.375752630155169 no 1233 0.371107331061865 1834 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_797 k781-0471 270 µM 0.326278346826262 0.376774332094933 no 1234 0.372106884663785 1792 23738129 SGTC_207 4185-0010 4.486 µM 0.325551481340181 0.377055400422257 no 1235 0.372381863082146 1822 3761753 SGTC_2006 4011487 200 µM 0.32508787631561 0.377234703794272 no 1236 0.372557282181036 1834 45595294 SGTC_2960 9079389 5.97 µM 0.324049701694425 0.377636323031696 no 1237 0.37295020305587 1871 16457355 SGTC_311 1315-0136 58 µM 0.323807007692536 0.377730228629573 no 1238 0.373042075218438 1819 6759207 SGTC_2661 dactinomycin 12.96 µM 0.31997568859841 0.379213635248253 no 1239 0.374493380075859 1765 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2267 7931562 200 µM 0.319776882941587 0.379290657413021 no 1240 0.374568736471071 1620 934880 SGTC_2999 9069765 71.4286 µM 0.318942091271615 0.37961412835503 no 1241 0.374885212783456 1804 2097066 SGTC_716 1683-5115 658 µM 0.31885171934807 0.379649151362206 no 1242 0.374919478573693 1853 723597 SGTC_1712 st032288 53.4 µM 0.316819850105156 0.380436848238137 no 1243 0.375690150662535 1753 2883011 SGTC_1017 4239-0030 168 µM 0.316779956239971 0.380452318910176 no 1244 0.375705287070038 1671 1149593 SGTC_545 4218-0007 221 µM 0.316687920684365 0.380488010638398 no 1245 0.375740207646851 1770 2840508 SGTC_1596 piperlongumine 63 µM 0.316672885831124 0.380493841306671 no 1246 0.3757459123405 1866 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3120 9124077 49.47 µM 0.316437646499497 0.38058507303536 no 1247 0.375835173038123 1781 18774327 YGL155W CDC43 SGTC_1383 3049-0032 20.7 µM 0.316307684194217 0.380635478534178 no 1248 0.375884489605827 1872 712864 SGTC_1106 tegaserod maleate 11.7 µM 0.313401693377554 0.381763086275857 no 1249 0.376987748926267 1788 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2836 9010338 19.48 µM 0.308992761735859 0.38347579264641 no 1250 0.378663516444321 1622 2994051 SGTC_3257 9139206 32.98 µM 0.307953711358768 0.38387975831536 no 1251 0.379058777336464 1846 4910041 SGTC_2533 agelasine 13.65 µM 0.307747288646442 0.383960027106779 no 1252 0.379137316827428 1934 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1515 3460-0031 42.1 µM 0.30737294147224 0.384105607096972 no 1253 0.379279760763244 1823 2876596 SGTC_741 4582-0002 126 µM 0.305813778148195 0.384712126292342 no 1254 0.37987321865144 1743 2912688 SGTC_2219 9098279 200 µM 0.305803137569441 0.384716266480711 no 1255 0.379877269704803 1871 902349 SGTC_3043 9092303 49.47 µM 0.305667462807883 0.384769057907286 no 1256 0.379928924601256 1705 25236084 SGTC_26 0302-0163 425.158 µM 0.304930128660851 0.38505599400453 no 1257 0.380209684245981 1818 3100915 SGTC_213 1246-0773 967 nM 0.304755282083861 0.385124045385859 no 1258 0.380276271009685 1808 6251622 SGTC_2943 9068529 45.32 µM 0.304316846392736 0.385294702853858 no 1259 0.380443255927671 1797 3270634 SGTC_2701 st077767 14.721 µM 0.302979969513753 0.385815208140009 no 1260 0.380952563298729 1773 5721188 SGTC_416 estradiol valerate 100 µM 0.302475890528305 0.386011521821562 no 1261 0.381144654896564 1798 13791 A steroid. SGTC_2233 sulbentine 40.3845 µM 0.302362643702812 0.386055629842511 no 1262 0.381187814393855 1797 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_260 nsc-65238 3.989 µM 0.301780099481356 0.38628254575966 no 1263 0.381409851163325 1834 3246252 SGTC_3272 9137413 49.47 µM 0.30107657961553 0.386556636644528 no 1264 0.381678049841095 1688 17614870 SGTC_957 1187-1561 14.1 µM 0.300728690927463 0.386692194777499 no 1265 0.381810694369448 1810 1538454 SGTC_1086 cerivastatin 2.18 µM 0.300140743353221 0.386921325557797 no 1266 0.382034901144402 1845 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2063 5246145 200 µM 0.298715037409484 0.387477105145832 no 1267 0.382578741221696 1833 711240 SGTC_600 1495-0418 41.6 µM 0.298706744331867 0.387480338692639 no 1268 0.382581905321248 1788 5377768 SGTC_1747 st037496 66.6 µM 0.297749607089517 0.387853587639166 no 1269 0.382947139305057 1767 723305 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.297201073170731 0.388067542792565 no 1270 0.383156501299248 1842 6708630 An antioxidant. SGTC_2880 9042983 58.44 µM 0.296900801948166 0.388184677704054 no 1271 0.383271121948679 1778 6464714 SGTC_861 0443-0273 110 µM 0.294637725000034 0.389067823832975 no 1272 0.38413532019239 1845 6149169 SGTC_2907 7721985 69.9 µM 0.294186889902994 0.389243826957808 no 1273 0.384307548986262 1741 3267881 SGTC_1188 1403-0014 4.57 µM 0.29232887283465 0.389969424336751 no 1274 0.385017592566359 1787 9614867 SGTC_3151 9099821 49.47 µM 0.291263430170103 0.390385676825965 no 1275 0.385424927005478 1744 17174189 SGTC_2531 methyl deoxycholate 70.07 µM 0.290965149731883 0.390502233063588 no 1276 0.385538986684354 1749 16667744 Haematoxylin. SGTC_837 0091-0265 12.5 µM 0.290672641878796 0.390616543159768 no 1277 0.385650848594216 1774 759367 SGTC_1914 st062367 72.6 µM 0.29021714546125 0.390794566908634 no 1278 0.385825060114115 1759 978205 SGTC_2188 6126565 140.678 µM 0.289470553406275 0.391086410389827 no 1279 0.386110655376434 1882 874518 SGTC_1644 st010134 20.9 µM 0.288751235688826 0.391367650332248 no 1280 0.386385875723931 1919 3818134 SGTC_2874 9043904 71.43 µM 0.288711066739717 0.39138335732535 no 1281 0.386401246574796 1783 4463428 SGTC_2142 5622915 118.518 µM 0.287912120311258 0.391695800718122 no 1282 0.3867070044558 1787 5322196 SGTC_16 erodoxin 22.806 µM 0.287483833751708 0.391863319208731 no 1283 0.386870939274193 1823 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1249 0481-0015 10.2 µM 0.285629395150571 0.392588888745148 no 1284 0.387580993454183 1753 4227577 SGTC_984 1492-0255 2.91 µM 0.282749396554498 0.393716459514263 no 1285 0.388684473815047 1828 1585198 SGTC_2856 9022925 19.48 µM 0.280383406989954 0.394643454300494 no 1286 0.389591683008388 1827 4944862 SGTC_1016 4226-1401 38 µM 0.279103803884412 0.395145051879416 no 1287 0.390082582004739 1825 2901613 SGTC_1320 1313-0481 95.3 µM 0.277892038632561 0.395620217630264 no 1288 0.390547617773904 1946 6813365 YLR208W SEC13 SGTC_2411 st077133 39.94 µM 0.277455281313474 0.395791520009081 no 1289 0.39071526934358 1958 1403142 YNL221C POP1 SGTC_2234 tolnaftate 200 µM 0.275861458833714 0.396416810189832 no 1290 0.391327238527122 1897 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_649 1123-0311 367 µM 0.275561093206839 0.396534679856891 no 1291 0.391442598057002 1915 693629 YIL048W NEO1 SGTC_3104 9120930 49.47 µM 0.272802496778868 0.397617650909724 no 1292 0.392502520093547 1835 17014836 SGTC_2335 9018011 154.17 µM 0.272677831526415 0.39766661076075 no 1293 0.392550438515977 1928 6458208 SGTC_1063 disulfiram 1.84 µM 0.270933231908438 0.39835193708446 no 1294 0.393221192607249 1840 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2933 9026794 32.47 µM 0.27085830432636 0.398381377722177 no 1295 0.393250007468876 1864 17586027 SGTC_223 busulfan 5 mM 0.270108009804582 0.398676216237448 no 1296 0.393538580068974 1899 2478 A DNA alkylator. SGTC_2505 galangin 7.89 µM 0.269374360523288 0.398964569706077 no 1297 0.393820807260004 1771 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2997 9067075 71.4286 µM 0.268099120090501 0.399465921285741 no 1298 0.394311511557371 1885 27209819 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.265539721090743 0.400472630166344 no 1299 0.395296857367546 1715 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_732 3970-1727 52.7 µM 0.264511978658258 0.400877066855128 no 1300 0.395692717891861 1960 1275699 SGTC_709 3807-1509 243 µM 0.264411553601202 0.400916591779391 no 1301 0.395731404875444 1869 1886677 YPL242C IQG1 SGTC_3194 9111903 49.47 µM 0.262992315256383 0.401475278654007 no 1302 0.396278251114014 1887 17087251 SGTC_2885 9057732 51.95 µM 0.262920635230736 0.401503501037063 no 1303 0.396305875544372 1840 6471414 SGTC_1138 3761-0006 1.03 µM 0.262644938902501 0.401612054995615 no 1304 0.396412129715768 1878 12061087 SGTC_2687 chenodiol 100 µM 0.262617929465041 0.401622690226026 no 1305 0.396422539645912 1853 5702181 A cholesterol synthesis inhibitor. SGTC_2941 9056145 11.23 µM 0.260629847021011 0.402405716724881 no 1306 0.397188985182516 1967 2119517 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.259641328958701 0.40279520063895 no 1307 0.39757022670122 1984 5024745 SGTC_3080 9117754 49.47 µM 0.259248468864645 0.402950017428882 no 1308 0.397721768151499 1957 9550191 SGTC_1723 st034307 2.5525 µM 0.25865626915216 0.40318341795595 no 1309 0.397950231824781 1819 867466 SGTC_2643 anethole 100 µM 0.25813351672192 0.403389476262771 no 1310 0.398151932639269 1863 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_60 0986-0278 202 µM 0.257422418192479 0.403669819799696 no 1311 0.398426349326014 1679 3110598 SGTC_2812 7970281 58.44 µM 0.257150609834525 0.403776990630731 no 1312 0.398531254888484 1936 2233435 SGTC_2297 7971671 152.32 µM 0.256235412100087 0.404137895377577 no 1313 0.398884533116699 1927 909016 SGTC_2834 9001755 58.44 µM 0.255029512869386 0.404613561716397 no 1314 0.399350152371041 1825 2989575 SGTC_2667 digitoxin 100 µM 0.254803042666197 0.404702908521352 no 1315 0.399437612558861 1987 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_673 1082-0474 110 µM 0.254565096287719 0.404796788248846 no 1316 0.399529510150688 1798 3098046 SGTC_1009 4106-0057 9.87 µM 0.252979512117925 0.405422506726992 no 1317 0.400142022654987 1995 2928005 SGTC_3023 9089636 49.47 µM 0.252965878959077 0.405427887825962 no 1318 0.400147290223378 2005 17249241 SGTC_2041 5107442 45.335 µM 0.252614176607196 0.405566713272224 no 1319 0.40028318695752 1962 793005 SGTC_249 wiskostatin 11.211 µM 0.252496979002107 0.405612976648414 no 1320 0.400328474443601 1952 2775510 A n-wasp and actin depolymerizer. SGTC_1891 st059073 26.2 µM 0.251067284972989 0.406177449712318 no 1321 0.400881044376487 2008 688754 SGTC_1633 st005664 67.9 µM 0.251057910399012 0.406181151634945 no 1322 0.400884668260495 1824 2063822 SGTC_1846 st056244 14.8 µM 0.250707698907103 0.406319452549536 no 1323 0.401020053942063 1903 5393182 SGTC_2946 9065502 71.43 µM 0.25058177557472 0.406369183393044 no 1324 0.40106873662219 1898 16489101 SGTC_3032 9089427 49.47 µM 0.250448281838294 0.406421905662059 no 1325 0.401120347741248 1851 17173707 SGTC_1518 st038567 90.8 µM 0.249475237544877 0.406806252812217 no 1326 0.401496596528508 1936 77966 SGTC_584 0986-0246 15.4 µM 0.248323829316278 0.407261168686764 no 1327 0.401941931589515 1966 53315 YDR232W HEM1 SGTC_2671 danthron 100 µM 0.248151089766384 0.407329428063749 no 1328 0.40200875379987 1858 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_560 2332-1943 155 µM 0.248059857897619 0.40736548018223 no 1329 0.402044046903408 1875 21177716 SGTC_908 3448-7491 47.7 µM 0.246966523080544 0.40779759452016 no 1330 0.402467066201553 1830 1203031 SGTC_2512 diallyl trisulfide 49.23 µM 0.246713636753254 0.407897557764358 no 1331 0.402564926069874 1960 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_977 1348-1378 135 µM 0.245637471296765 0.408323021363635 no 1332 0.402981439921657 1896 X977 SGTC_1436 4092-1007 8.32 µM 0.245633785094233 0.408324478895288 no 1333 0.402982866801082 1883 2881121 SGTC_3128 9127691 49.47 µM 0.245197455359294 0.408497013476091 no 1334 0.403151773295837 1881 41316314 SGTC_2212 7123476 200 µM 0.24421994631004 0.408883606850775 no 1335 0.403530239887769 1942 1085715 SGTC_1002 4049-0206 172 µM 0.243859140132392 0.409026323888316 no 1336 0.403669957694538 1830 4662749 SGTC_3175 9106517 49.47 µM 0.243758199112369 0.409066253311818 no 1337 0.403709048079147 1862 41468073 SGTC_588 3970-1144 52.9 µM 0.243220241597954 0.409279070052993 no 1338 0.403917393534025 1965 1888707 SGTC_1142 3253-1408 9.78 µM 0.242827418333867 0.409434488378792 no 1339 0.404069547200041 2002 256655 SGTC_1485 3909-9022 254 µM 0.242104185599485 0.409720668575235 no 1340 0.404349717514737 1961 714516 SGTC_2161 5662504 8.5105 µM 0.242062992047178 0.409736970142609 no 1341 0.404365676802769 1848 2859334 SGTC_1862 st057513 3.81 µM 0.242032451246552 0.409749056186188 no 1342 0.404377509083269 1867 5393163 SGTC_2406 ethylparaben 405.7 µM 0.240867336774525 0.410210195930129 no 1343 0.404828969188432 1627 8434 A possible steroid mimic. SGTC_176 1486-1328 72.834 µM 0.240026254246894 0.410543164546596 no 1344 0.405154951751953 1829 22310231 SGTC_1776 st049249 45.9 µM 0.239537689420311 0.410736607717167 no 1345 0.405344337499709 1833 1822314 SGTC_910 3454-3003 490 µM 0.238468911995047 0.411159856873936 no 1346 0.405758712273084 2024 820824 SGTC_352 k048-0007 5.11 µM 0.237183016917845 0.411669224369706 no 1347 0.406257405494569 1965 6811911 SGTC_1380 2291-0730 164 µM 0.236910140716251 0.411777335002545 no 1348 0.406363251381778 1831 2999191 SGTC_1512 0259-0544 12.2 µM 0.236896489225264 0.411782743753257 no 1349 0.406368546835276 1913 18476 SGTC_1187 1391-0724 117 µM 0.236443992746807 0.411962033331286 no 1350 0.406544081235778 1905 6997986 SGTC_568 1193-0097 7.48 µM 0.236285786758613 0.41202472254371 no 1351 0.406605457623225 1959 3646150 SGTC_1626 st003712 1.76 µM 0.235963102377552 0.412152593370508 no 1352 0.406730650903227 1926 24207035 SGTC_1179 1021-1431 9.29 µM 0.235486943467996 0.412341298907809 no 1353 0.406915405780128 1912 2840958 SGTC_13 0199-0087 65 µM 0.234560720840177 0.412708426268318 no 1354 0.407274849623275 1961 4589825 SGTC_2820 7989630 71.43 µM 0.234197849255204 0.412852278712863 no 1355 0.407415692320946 2035 2984098 SGTC_452 diindolylmethane 8 µM 0.233597733676211 0.413090206986104 no 1356 0.407648643670718 1945 3071 Inhibits expression of several cancer promoting factors. SGTC_2737 bleomycin 30.5 nM 0.231789134989206 0.413807456217465 no 1357 0.4083508981462 1929 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1696 st025591 34.7925 µM 0.231608398658896 0.413879147995913 no 1358 0.408421091844332 1887 2787147 SGTC_2858 9025781 8.96 µM 0.231332193293138 0.413988714544701 no 1359 0.408528369124144 2005 4894980 YPL153C RAD53 SGTC_2252 omeprazole 400 µM 0.230546361748079 0.414300478792495 no 1360 0.408833621048658 1976 4594 A proton pump inhibitor. SGTC_1575 cyproterone acetate 48 µM 0.230280884338333 0.414405814297928 no 1361 0.408936756789879 1841 9880 An androgen receptor antagonist and liver toxin. SGTC_1777 st045864 34.765 µM 0.228747923257176 0.415014179191388 no 1362 0.409532422389081 1930 4691462 SGTC_2322 7413319 38.22 µM 0.22830126535513 0.415191476501733 no 1363 0.409706020460984 1900 1840400 SGTC_833 3852-0053 558 µM 0.227620718404959 0.415461647408693 no 1364 0.409970555880869 1941 3123681 SGTC_1907 st060210 83.7 µM 0.226406321742371 0.41594385098816 no 1365 0.410442705770431 1999 688793 SGTC_1884 5633444 25 µM 0.226003280983955 0.416103915420581 no 1366 0.410599434245294 1926 5724239 SGTC_798 1287-0182 476 µM 0.225472580006078 0.416314700316735 no 1367 0.410805827093218 2031 1649755 SGTC_2673 kobusone 100 µM 0.225104993706976 0.416460713105699 no 1368 0.410948798128788 1955 6710676 An epoxy ketone and protein crosslinker. SGTC_3182 9108849 49.47 µM 0.223211949201946 0.417212851195061 no 1369 0.411685276210996 1927 17133045 SGTC_288 1315-0019 35.1 µM 0.221345751330345 0.417954619343649 no 1370 0.412411614450901 1927 6811474 SGTC_3081 9117243 49.47 µM 0.221274562009796 0.417982921160453 no 1371 0.412439327827012 2009 45595589 SGTC_2816 7982706 58.44 µM 0.219943323367677 0.418512242558003 no 1372 0.412957647583033 1887 2981853 SGTC_728 3030-5151 22.5 µM 0.219629823196132 0.4186369166575 no 1373 0.413079731457148 1919 3125388 SGTC_1456 k015-0012 13 µM 0.219584668410652 0.418654874680897 no 1374 0.413097316418365 2080 2989616 SGTC_1013 4112-3890 241 µM 0.219168212708671 0.418820506779716 no 1375 0.413259508049882 1886 705171 SGTC_2363 9053361 176 µM 0.218813123594392 0.41896174362472 no 1376 0.413397811721916 2012 6469797 YMR079W SEC14 SGTC_2026 5148700 152 µM 0.218518664165046 0.419078872909752 no 1377 0.413512508887153 1900 79838 SGTC_2888 9058547 12.99 µM 0.218193662543906 0.419208159512819 no 1378 0.41363911134528 1880 16476514 SGTC_3001 9076041 71.4286 µM 0.216884596629615 0.419728997991824 no 1379 0.41414914100567 1928 16004211 SGTC_2647 atorvastatin 60.16 µM 0.216729705415308 0.419790633932124 no 1380 0.414209498300933 2000 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2744 captopril 92.04 µM 0.216112288593168 0.420036342463755 no 1381 0.414450110567656 2029 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_426 0988-0037 14.6 µM 0.216013452805117 0.420075678264095 no 1382 0.414488630647155 2093 5383008 SGTC_2741 miltefosine 3.04 µM 0.214902559196391 0.420517859270336 no 1383 0.41492164477917 1944 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3229 9132204 49.47 µM 0.214744786253872 0.420580667490467 no 1384 0.414983151336194 1961 17682924 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.214687356195694 0.420603530466125 no 1385 0.415005540516026 1907 2333 A French combination drug. SGTC_1299 1079-1439 3.74 µM 0.213912414127457 0.420912062001211 no 1386 0.415307679613328 1902 323161 SGTC_2787 5284540 71.43 µM 0.2132275513581 0.421184770263439 no 1387 0.415574739749158 1906 736958 SGTC_2366 9070441 60.58 µM 0.212932552988118 0.421302248511953 no 1388 0.415689785483571 1895 6837235 SGTC_2497 7-hydroxyflavone 100 µM 0.212532698313653 0.421461495241562 no 1389 0.415845735421133 2025 5281894 SGTC_1695 st026914 34.495 µM 0.212517745735815 0.421467450527255 no 1390 0.415851567431063 1900 3289191 SGTC_104 0074-0074 590.992 µM 0.212464762959232 0.421488552556402 no 1391 0.415872232650996 2036 3943124 SGTC_926 2268-1401 59.4 µM 0.212378151240793 0.421523048837099 no 1392 0.41590601488868 2045 2931578 SGTC_1903 st060211 78.3 µM 0.21065902187061 0.422207879194448 no 1393 0.416576676399222 2044 688960 SGTC_592 k241-0073 46.5 µM 0.209694823542897 0.422592079220863 no 1394 0.416952932965549 2036 4230158 SGTC_2861 9024595 19.48 µM 0.209257233902591 0.42276646803268 no 1395 0.417123717534713 2064 16482810 SGTC_1371 2421-0008 32.7 µM 0.208629776683551 0.423016549532706 no 1396 0.417368631809076 1897 2827552 SGTC_1166 k206-0078 225 µM 0.207683771704729 0.423393651136763 no 1397 0.417737944852985 1906 5404595 SGTC_2987 9018338 71.43 µM 0.205690902917272 0.424188288489796 no 1398 0.418516182519926 2035 5055682 SGTC_3253 9135987 49.47 µM 0.205571278007234 0.424235997618139 no 1399 0.418562907573096 1995 4182430 SGTC_1587 estradiol valerate 56.1 µM 0.204857938129093 0.424520516773296 no 1400 0.418841559358986 2053 13791 A steroid. SGTC_2560 caryophyllene 100 µM 0.204469252138663 0.424675562676816 no 1401 0.418993408823075 1962 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_925 2064-1272 59.6 µM 0.204282737169318 0.424749967187617 no 1402 0.41906627963635 1870 6815817 SGTC_478 N-arachidonylglycine 10 µM 0.204032501225927 0.42484979546658 no 1403 0.419164050395282 2045 5283389 SGTC_831 k061-1017 217 µM 0.202256874254459 0.425558296146564 no 1404 0.419857956268315 2025 1240153 SGTC_3267 9137951 49.47 µM 0.201490415136312 0.425864198776384 no 1405 0.420157561681716 1939 16643986 SGTC_988 1497-1057 103 µM 0.200891095710832 0.426103425132811 no 1406 0.420391865188614 2093 3533044 SGTC_1259 0671-0132 43 µM 0.200084707408038 0.426425348697573 no 1407 0.420707166628483 1912 X1259 SGTC_2405 ticlatone 3.52 µM 0.198993792088543 0.426860938147024 no 1408 0.421133800340831 1850 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2292 7671323 168.05 µM 0.198328377456952 0.427126674092313 no 1409 0.42139407532103 1935 937504 SGTC_454 lyso-paf C-16 6.67 µM 0.198132534288296 0.427204891135131 no 1410 0.421470685349447 1871 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2239 6685329 187.64 µM 0.196983198024535 0.427663977665074 no 1411 0.421920343105567 1916 805680 SGTC_2346 9031566 143.75 µM 0.196072966558632 0.428027626617585 no 1412 0.422276527555814 2033 4771086 SGTC_1360 1598-0022 39.8 µM 0.195478050077585 0.428265336312502 no 1413 0.422509359856641 2024 761525 SGTC_3015 9080845 49.47 µM 0.194243901488453 0.428758545736633 no 1414 0.422992454515537 2052 5296973 SGTC_3113 9123498 49.47 µM 0.191058307664059 0.430032134164349 no 1415 0.424239955766393 2095 8897275 SGTC_257 daunorubicin 18.5 µM 0.190295758402094 0.43033710703025 no 1416 0.424538688614749 2075 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3262 9137218 49.47 µM 0.189427207096087 0.430684524820312 no 1417 0.424879001145466 2036 17650664 SGTC_2269 7935389 174.42 µM 0.189210034165113 0.430771401704943 no 1418 0.424964101793281 1887 97605 SGTC_2192 5915882 198.485 µM 0.187342713426546 0.431518534134136 no 1419 0.425695967658208 2020 2876149 SGTC_81 0411-0046 9.971 µM 0.187128262740848 0.431604353590464 no 1420 0.425780034541306 2010 12925265 SGTC_1744 st037937 38.9 µM 0.185897446582187 0.432096967250791 no 1421 0.42626259231669 2024 1016152 SGTC_1737 st035557 69.7 µM 0.185778693664532 0.432144501724975 no 1422 0.426309156823031 1943 5716916 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.185487832551484 0.432260931897253 no 1423 0.426423211446594 2000 6708739 YPR165W RHO1 SGTC_3340 9146634 11.102 µM 0.185415427915204 0.432289916006864 no 1424 0.426451604248169 1964 4907387 SGTC_1357 1503-1303 39.5 µM 0.185327047230294 0.432325295940363 no 1425 0.426486262424533 1987 292895 SGTC_2624 nerol 100 µM 0.185263291828726 0.432350818390766 no 1426 0.426511264234667 2030 637566 A natural product oil. SGTC_3124 9127567 49.47 µM 0.184845554941795 0.432518053067316 no 1427 0.426675087904786 2086 17592030 SGTC_1344 1488-0097 29.1 µM 0.18393462182079 0.432882773320064 no 1428 0.427032371933067 2007 747966 SGTC_333 3486-0131 40.1 µM 0.183064039170342 0.433231391458121 no 1429 0.427373885748992 2081 6744690 SGTC_697 0508-1955 564 µM 0.18281767011797 0.433330057498518 no 1430 0.42747054176131 2093 6243113 SGTC_1341 1486-1360 280 µM 0.180260109042956 0.434354555606086 no 1431 0.428474185501974 1947 3976547 SGTC_1603 st002045 67.8 µM 0.180238236706206 0.434363319055475 no 1432 0.428482770697427 2090 5887985 SGTC_2045 5106652 78.05 µM 0.180111299835566 0.434414178676872 no 1433 0.42853259584729 2070 673349 SGTC_1950 st077106 7.18 µM 0.178400877368518 0.435099596819014 no 1434 0.429204080158505 1948 13831864 SGTC_735 3076-0345 636 µM 0.178161653024913 0.435195476862381 no 1435 0.429298012161447 2073 2888990 SGTC_1237 0330-0133 46.1 µM 0.178128302119651 0.435208844058303 no 1436 0.429311107791181 1977 X1237 YHR072W ERG7 SGTC_2514 salinomycin 42.74 µM 0.177937728711647 0.43528522817494 no 1437 0.429385940199111 2114 23682228 A polyether potassium ionophore. SGTC_2759 disulfiram 3.38 µM 0.177886296912383 0.435305843073293 no 1438 0.429406136344591 1988 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2852 9023854 51.95 µM 0.1757031746667 0.436181043755096 no 1439 0.430263570542564 2046 19798528 SGTC_2204 7233102 200 µM 0.175334430463529 0.436328902079056 no 1440 0.430408429595882 2043 2172480 SGTC_302 1094-0063 18.9 µM 0.174576336144158 0.436632909172778 no 1441 0.430706272017549 1981 5440289 SGTC_3036 9090181 49.47 µM 0.174474763869407 0.436673644012566 no 1442 0.430746181042764 2006 25236586 SGTC_2735 sertaconazole 140 nM 0.173011166390964 0.437260683733561 no 1443 0.431321325236783 2133 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2964 9083345 53.42 µM 0.172892958907938 0.437308102056478 no 1444 0.431367783143437 1960 17741579 SGTC_3191 9110352 49.47 µM 0.17258230405948 0.437432723940121 no 1445 0.431489881241252 2040 17122424 SGTC_47 0149-0135 24.25 µM 0.171600348679854 0.437826684611084 no 1446 0.431875866656555 1938 5239155 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.171428063252096 0.437895811921763 no 1447 0.431943595048398 2074 4000243 SGTC_1568 digitonin 820 nM 0.170324564990748 0.438338621256485 no 1448 0.432377446722217 2142 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1135 dihydrocapsaicin 536.708 nM 0.168348938869855 0.439131588620113 no 1449 0.433154387782022 1921 107982 A Capsaicinoid. SGTC_121 0557-0495 61.343 µM 0.168159334080367 0.439207704183875 no 1450 0.433228966008074 2067 3104427 SGTC_2658 polymyxin b sulfate 77.05 µM 0.167842063836871 0.439335075209217 no 1451 0.433353764860319 2021 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1482 3346-2049 8.48 µM 0.166806936681418 0.439750680028975 no 1452 0.433760980239591 2086 3826804 SGTC_2284 7945075 39.21 µM 0.16603415246029 0.440060997158832 no 1453 0.434065036699841 2133 1245402 SGTC_307 1501-1223 22.3 µM 0.164805374232338 0.440554497754037 no 1454 0.434548586931213 2037 2830329 SGTC_3111 9122088 49.47 µM 0.163108561888232 0.441236121361682 no 1455 0.435216479332419 2117 16876704 SGTC_1434 4073-0095 163 µM 0.162953233272269 0.441298526885045 no 1456 0.435277628417778 2097 24133745 SGTC_655 k060-0012 42 µM 0.161169189967351 0.44201539626797 no 1457 0.43598007334759 2005 5994525 SGTC_918 glabranin 770.725 nM 0.159350774073044 0.442746272805379 no 1458 0.436696259924262 2043 124049 Also referred to as licorice root. SGTC_1053 3366-3204 134 µM 0.159049036956077 0.442867569029017 no 1459 0.436815119804555 1973 3632071 YPR165W RHO1 SGTC_612 0302-0167 22.4 µM 0.158806530324755 0.44296505889102 no 1460 0.436910651826524 2085 235821 SGTC_3178 9107506 49.47 µM 0.15802069793466 0.443280994323388 no 1461 0.437220244516632 2072 8897194 SGTC_71 0417-1750 47.813 µM 0.15457001052725 0.444668730151208 no 1462 0.438580156967921 2151 6811472 SGTC_2534 helenine 20.12 µM 0.15339739596917 0.445140466642522 no 1463 0.439042449150079 2034 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.153149158975661 0.44524034102913 no 1464 0.43914032492036 2070 5106787 A p450 inhibitor. SGTC_1750 st081859 2.357 µM 0.152495548988612 0.44550332769484 no 1465 0.439398050387354 2043 5291695 SGTC_2400 5203494 178.7 µM 0.151425040000029 0.445934109693069 no 1466 0.439820219071323 2120 6777674 SGTC_2843 9000894 45.46 µM 0.149607305210568 0.446665727707149 no 1467 0.440537222166077 2145 2242070 SGTC_116 0155-0182 31.788 µM 0.149443569289743 0.446731638543612 no 1468 0.440601817193222 1992 771486 SGTC_2072 5231554 129 µM 0.149121925653515 0.44686111839296 no 1469 0.440728712578131 2179 789545 SGTC_922 1866-0035 480 µM 0.148931936158544 0.446937602627932 no 1470 0.440803670411468 2000 3156169 SGTC_1505 k297-0037 20.6 µM 0.147652821748523 0.447452588054407 no 1471 0.441308383100916 1995 4089396 SGTC_3226 9131256 49.47 µM 0.147089568721233 0.447679388021559 no 1472 0.441530661639394 2128 17178073 SGTC_2796 7949634 45.45 µM 0.146761230179479 0.447811605009574 no 1473 0.441660243542999 2068 2971588 SGTC_2068 5226020 147 µM 0.146429650035608 0.447945133226751 no 1474 0.441791111112559 2023 1810509 SGTC_1969 st069479 40.1 µM 0.145947804462377 0.448139184247427 no 1475 0.441981296545786 2147 3895485 SGTC_3296 9122258 64.045 µM 0.1456706143415 0.448250821128314 no 1476 0.442090710116451 2045 4730474 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.144523204977137 0.448712977785642 no 1477 0.442543666940599 1998 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1790 st045711 43.5 µM 0.143897235159745 0.44896513699161 no 1478 0.44279080949462 2158 585119 SGTC_1716 st033144 30.6155 µM 0.142183019766139 0.449655779018843 no 1479 0.443467721892016 2161 674617 SGTC_2468 5987765 72.9 µM 0.140819781113779 0.450205124646808 no 1480 0.444006157857922 2089 26772094 SGTC_2513 baicalein 25.65 µM 0.139659143737091 0.4506729030855 no 1481 0.444464654264454 2027 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1614 st002383 48.6 µM 0.138511704972743 0.451135429374862 no 1482 0.444918009776036 2198 1947235 SGTC_2135 5326629 150.42 µM 0.138245664133117 0.451242678480737 no 1483 0.445023133393111 2028 5020077 SGTC_88 0180-0332 8.668 µM 0.138028858810511 0.451330081893679 no 1484 0.445108804903266 2159 3101745 SGTC_2775 cyproheptadine 69.59 µM 0.135679351763479 0.452277418205674 no 1485 0.446037385830349 2177 2913 A selective serotonin reuptake inhibitor. SGTC_1916 st067606 49.2 µM 0.135667861026198 0.452282052016826 no 1486 0.446041927973953 2129 19590279 SGTC_919 tnp00227 403.569 nM 0.135164869909186 0.452484897045854 no 1487 0.446240760952863 2065 1269246 A methoxyflavone. YNL221C POP1 SGTC_632 0781-2353 4.65 µM 0.135031264550757 0.45253877917524 no 1488 0.446293577582189 2103 6811515 YHR007C ERG11 SGTC_606 k015-0008 38.6 µM 0.134220999706296 0.452865572146312 no 1489 0.446613910398057 2148 1970475 SGTC_866 0495-0101 262 µM 0.134111169303633 0.452909870993476 no 1490 0.44665733380296 1953 635694 SGTC_894 0960-0238 55.9 µM 0.133806043975754 0.453032942907688 no 1491 0.446777973888357 2152 6741907 YDL195W SEC31 SGTC_904 1141-0088 396 µM 0.133071851256019 0.453329097076847 no 1492 0.447068278287141 1985 1378119 SGTC_66 0109-0187 42.4 µM 0.131959385385762 0.453777886168168 no 1493 0.447508208257837 2192 759417 SGTC_1567 st069303 68.4 µM 0.131651320697559 0.453902175562207 no 1494 0.447630045360069 2061 5581319 SGTC_3346 9158254 43.5805 µM 0.129678390793268 0.454698265112057 no 1495 0.448410439916238 2084 17639500 SGTC_295 k015-0027 31 µM 0.128653369105991 0.455111939811893 no 1496 0.448815967364484 2107 3887424 SGTC_3227 9130768 49.47 µM 0.128179860959896 0.455303053053556 no 1497 0.449003318607619 2136 17720899 SGTC_2817 7995342 71.43 µM 0.126708802199806 0.455896854795952 no 1498 0.44958543942416 2073 18879975 SGTC_3306 9127676 59.7925 µM 0.126410688874949 0.456017202087006 no 1499 0.449703420764297 2040 41905287 SGTC_875 0709-0210 25.7 µM 0.126271310647473 0.456073469967743 no 1500 0.449758582622541 2226 6251364 SGTC_3260 9137109 49.47 µM 0.12511168925828 0.456541650579706 no 1501 0.450217564660941 2186 17478346 SGTC_42 0133-0086 60.653 µM 0.124795031124511 0.456669507303914 no 1502 0.450342910614274 2164 162923 Model of phenazepam hydroxylation. SGTC_1947 st076332 61.6 µM 0.123234850972502 0.457299524866656 no 1503 0.45096056440405 2193 24208416 SGTC_3196 9111891 49.47 µM 0.122491243892845 0.457599839285627 no 1504 0.451254990067907 2194 18891510 SGTC_3232 9132874 49.47 µM 0.122397707925373 0.457637616598195 no 1505 0.451292026837159 2050 3784940 SGTC_1105 epirubicin 18.1 µM 0.121602100050438 0.457958962197152 no 1506 0.451607075117362 2047 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2396 5342950 42.78 µM 0.12154722995238 0.457981125216111 no 1507 0.451628803944212 2066 1886677 SGTC_1793 st048256 72.231 µM 0.121283720971083 0.458087563049645 no 1508 0.451733156805904 2208 672022 SGTC_1652 st011932 78 µM 0.120556618712557 0.458381273307573 no 1509 0.452021115695997 2182 1551076 SGTC_2810 7959871 45.46 µM 0.12008975818424 0.458569871874828 no 1510 0.452206022730301 2148 2974535 SGTC_2715 st079500 56.4 µM 0.11981449373804 0.458681075368778 no 1511 0.452315050156335 2129 28246688 SGTC_754 3474-0146 171 µM 0.119699169302303 0.458727666002204 no 1512 0.452360729214797 1989 24762078 SGTC_750 4073-0104 132 µM 0.118214830765864 0.459327383511455 no 1513 0.452948719551955 2198 22330957 SGTC_1703 st026983 48.3 µM 0.117856325274805 0.459472244465951 no 1514 0.453090749684962 2205 1104023 SGTC_3203 9113543 49.47 µM 0.116386773531729 0.460066100794236 no 1515 0.453673008673342 2109 17018012 SGTC_1940 st075990 51.1 µM 0.115366279566808 0.460478542171905 no 1516 0.454077402737006 2131 1084979 SGTC_2353 9059630 146.67 µM 0.115282394849043 0.460512446796557 no 1517 0.454110646097534 2162 4779114 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.115169627606911 0.460558025646465 no 1518 0.454155336056274 2186 16486 A toxic proline analog. SGTC_3153 9100258 49.47 µM 0.115016165182231 0.460620053719086 no 1519 0.454216154556646 2069 25236848 SGTC_1050 3232-1156 69.3 µM 0.114694307510675 0.46075014868153 no 1520 0.454343713050397 2080 700529 SGTC_2923 7992654 58.14 µM 0.113802562379119 0.461110614219236 no 1521 0.45469715365364 2102 2985126 SGTC_40 0327-0103 19.753 µM 0.11282153858884 0.461507205311399 no 1522 0.455086021020845 2133 409036 SGTC_2227 7312221 64.1025 µM 0.112697781944424 0.461557238204427 no 1523 0.455135079899793 2190 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_776 4476-4378 112 µM 0.112301481377336 0.461717460470597 no 1524 0.455292183632952 2054 2892008 SGTC_2739 tacrine 100.86 µM 0.112160759457888 0.461774355109762 no 1525 0.455347971103069 2134 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1349 flufenamic acid 69 µM 0.111672113868144 0.461971923252367 no 1526 0.455541695453371 2173 3371 A non-steroidal anti-inflammatory. SGTC_421 streptovitacin 30 mM 0.111017085647572 0.462236777577217 no 1527 0.455801399047663 2086 91467 include heat shock SGTC_2472 5377652 49.4 µM 0.108813495994713 0.463127899984249 no 1528 0.456675209563773 2057 1610903 SGTC_1615 st002656 86.5 µM 0.108113013072762 0.463411211314446 no 1529 0.456953022860477 2223 1584458 SGTC_2229 7354935 190 µM 0.106812976996986 0.463937061857399 no 1530 0.457468676110339 2210 318112 SGTC_59 0330-0160 1.33 µM 0.106746042223033 0.463964137963441 no 1531 0.457495227422185 2150 4293482 SGTC_2250 alverine citrate 130 µM 0.105459772723133 0.464484485273727 no 1532 0.458005494327437 2141 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2589 lobaric acid 100 µM 0.10524357271704 0.46457195278607 no 1533 0.458091268325766 2104 73157 A novel microtubule depolymerizer. SGTC_1274 0865-0114 173 µM 0.105204705375175 0.464587677434025 no 1534 0.458106688547756 2135 870624 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.103457488618511 0.465294609604979 no 1535 0.458799943777426 2159 6708514 SGTC_3219 9131112 49.47 µM 0.103406190412957 0.465315366767989 no 1536 0.458820299623888 2239 17612988 YMR079W SEC14 SGTC_618 k072-0232 33.2 µM 0.103002615821074 0.465478671354014 no 1537 0.458980447436639 2153 5872756 YGL099W LSG1 SGTC_514 4466-0038 2.65 nM 0.102046991600849 0.465865383392584 no 1538 0.459359687919073 2114 5722064 SGTC_2113 5491891 107.031 µM 0.101931068843288 0.465912296004061 no 1539 0.459405694510187 2145 789979 SGTC_2352 9027995 87.8 µM 0.100619896309331 0.46644294532499 no 1540 0.459926100946288 2149 2997347 SGTC_2427 5545055 42.75 µM 0.100399972729042 0.46653195725104 no 1541 0.460013395708635 2154 5372858 SGTC_143 4032-1194 15.74 µM 0.0999473169749939 0.46671517052021 no 1542 0.460193075439034 2142 1806963 SGTC_1561 5-methoxyflavone 52.9 µM 0.0991051950383895 0.467056039697353 no 1543 0.460527373676566 2239 94525 SGTC_825 1988-2224 89.6 µM 0.0988991673119221 0.467139438080168 no 1544 0.460609165027469 2155 1180859 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.098855314935882 0.467157189359065 no 1545 0.460626574283408 2092 803109 SGTC_2995 9067767 71.4286 µM 0.0979899706478793 0.467507490829157 no 1546 0.46097012865156 2143 11673567 SGTC_2582 agaric acid 100 µM 0.0964938455667493 0.468113198940425 no 1547 0.461564180822568 2187 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2348 9022543 33.42 µM 0.0954273282216768 0.468545024976534 no 1548 0.461987705170263 2161 3162678 YDL140C RPO21 SGTC_229 benomyl 22.8748 µM 0.0945557334533487 0.4688979556162 no 1549 0.462333855908779 2145 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1258 0671-0043 57.1 µM 0.092563760827837 0.469704646743927 no 1550 0.463125067385454 2142 4298767 SGTC_2111 5486399 200 µM 0.0922237724969295 0.469842344671327 no 1551 0.463260125404135 2230 689674 SGTC_561 1550-0330 72.9 µM 0.0919257823686526 0.469963035965312 no 1552 0.463378503409557 2149 6812934 SGTC_1449 4112-4002 201 µM 0.0917102531954324 0.470050330828476 no 1553 0.463464125427209 2077 2059539 SGTC_3249 9135183 49.47 µM 0.0915813548516099 0.470102538663858 no 1554 0.463515332929515 2195 4902779 SGTC_1583 clindamycin 39.6 µM 0.0915515352715247 0.470114616593813 no 1555 0.46352717945347 2069 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1665 st014639 11.4 µM 0.0912681462726572 0.470229400012699 no 1556 0.463639763958117 2247 981133 YIL048W NEO1 SGTC_1496 4469-0713 57.4 µM 0.090117989013748 0.470695283131052 no 1557 0.464096727108888 2251 746691 SGTC_2217 6934799 96.0675 µM 0.0895310566281494 0.470933041674493 no 1558 0.46432993653093 2244 675606 SGTC_1311 1190-0148 100 µM 0.089046343565992 0.471129400337813 no 1559 0.464522539769175 2231 1961333 SGTC_2760 etidronate 98.04 µM 0.0890329415866267 0.47113482961835 no 1560 0.464527865233195 2207 3305 A chelator and antioxidant. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0887202122706477 0.471261521021715 no 1561 0.464652134404711 2260 16725076 SGTC_1114 scopoletin 1.73284 µM 0.0885259547375878 0.471340219168756 no 1562 0.464729328209773 2258 5280460 A coumarin with genotoxic properties. SGTC_199 4063-0024 41.6 µM 0.0880797116000471 0.471521006651462 no 1563 0.464906660748235 2230 306215 SGTC_1822 st052468 42 µM 0.0878794098116911 0.471602157274522 no 1564 0.464986260934639 2212 2873678 SGTC_2210 7115885 190.385 µM 0.0871352916669209 0.471903640923565 no 1565 0.465281986681704 2227 2927039 SGTC_414 piperonyl butoxide 100 µM 0.0868707588697881 0.472010821761228 no 1566 0.465387121335012 2152 5794 A potent inhibitor of cytochrome P450. SGTC_1856 st057054 55.7 µM 0.0867536942729654 0.472058253508631 no 1567 0.465433647701676 2245 1266018 SGTC_344 k064-0035 6.43 µM 0.0854185650404325 0.472599243497075 no 1568 0.465964317167097 2133 5088750 SGTC_3123 9126162 49.47 µM 0.0854155729197229 0.472600455951721 no 1569 0.465965506503887 2252 25239884 SGTC_731 3966-0296 387 µM 0.0826940297657881 0.473703372020619 no 1570 0.467047416085531 2241 660956 SGTC_196 k015-0023 18.111 µM 0.0820609884390938 0.473959943718782 no 1571 0.467299107585291 2139 5211998 SGTC_367 0335-0881 7.1 µM 0.0817715959588216 0.474077238117251 no 1572 0.467414171776133 2213 23828853 SGTC_1327 1436-0082 2.18 µM 0.0817372934859616 0.474091141488496 no 1573 0.467427810826363 2121 15992205 SGTC_1948 st076329 66.6 µM 0.0814340004708241 0.474214072637922 no 1574 0.467548405213128 2276 24208413 SGTC_2325 6158266 200 µM 0.0805132467744662 0.474587288807977 no 1575 0.467914530517933 2182 3623240 SGTC_2181 6316240 54.2555 µM 0.0789411510046133 0.475224569835058 no 1576 0.468539715792293 2175 12779990 SGTC_734 2023-0417 80 µM 0.0788885605803786 0.475245889539036 no 1577 0.468560631108926 2241 3935732 SGTC_336 4111-0029 111 µM 0.0785902467216735 0.475366824741555 no 1578 0.468679272766081 2168 3131175 SGTC_2770 toltrazuril 17.5 µM 0.0783570041587756 0.475461381891763 no 1579 0.468772037019387 2274 68591 Kills coccidiodes. SGTC_2451 5856223 45.7 µM 0.0782425575099103 0.475507779370853 no 1580 0.468817554880645 2211 2179896 SGTC_2625 euphol 100 µM 0.0779688266869375 0.475618753124132 no 1581 0.468926425090747 2282 6708538 A triterpene alcohol. SGTC_3325 9138760 55.175 µM 0.0776683710421903 0.475740563617159 no 1582 0.469045927165615 2209 43844959 SGTC_1554 st069299 38.7 µM 0.0771768830746382 0.475939827168179 no 1583 0.46924141571043 2206 24207999 SGTC_720 r052-1644 49.9 µM 0.0767294583830558 0.476121231416061 no 1584 0.469419384607569 2215 1422863 YOR257W CDC31 SGTC_2027 5150920 200 µM 0.0766649323482875 0.476147393315764 no 1585 0.469445051168636 2241 786715 SGTC_2485 5633444 17.78 µM 0.0765426952431269 0.476196954288793 no 1586 0.469493673846149 2177 5724239 SGTC_1238 0333-0287 48.8 µM 0.0745057722640739 0.477022877295956 no 1587 0.470303974166247 2239 7226 SGTC_1976 st070609 63.5 µM 0.0739015462664557 0.477267895468781 no 1588 0.470544362736383 2266 682556 SGTC_1468 k284-1086 134 µM 0.0736392582643064 0.477374257900686 no 1589 0.470648716173642 2178 15996457 SGTC_2018 5133068 143 µM 0.0704573451740796 0.478664706176133 no 1590 0.471914824878486 2275 785362 SGTC_2036 5160441 105 µM 0.0694411287137616 0.479076888017696 no 1591 0.472319245966836 2221 134534 YIL048W NEO1 SGTC_2320 7373003 200 µM 0.0689779022230849 0.479264782160053 no 1592 0.472503604533762 2220 5415828 SGTC_974 1326-0144 138 µM 0.0687749325302637 0.479347112274597 no 1593 0.472584385886512 2205 5411856 SGTC_1573 oleylamine 1.06 µM 0.0679602813387045 0.479677566133519 no 1594 0.472908626025263 2245 5356789 An amine of the fatty acid oleic acid. SGTC_2371 9071574 200 µM 0.067527654666293 0.479853061846003 no 1595 0.473080823513247 2285 45596039 SGTC_2000 st075254 36.4 µM 0.067526878758945 0.479853376597598 no 1596 0.473081132350552 2290 17234175 SGTC_2351 9026858 72.31 µM 0.0674133412506765 0.479899433922451 no 1597 0.473126324284121 2261 1409300 SGTC_2430 5571206 200 µM 0.0669170176989603 0.480100774362351 no 1598 0.473323882619942 2286 1731771 SGTC_761 k216-0224 480 µM 0.0658417835493385 0.480536975152476 no 1599 0.473751894964191 2306 1340404 SGTC_374 0880-0231 82.3 µM 0.0655481526552931 0.480656099352379 no 1600 0.473868784232852 2267 6833587 SGTC_3293 9120939 62.045 µM 0.0652063997406398 0.480794748526834 no 1601 0.474004832859676 2268 934087 SGTC_262 fenpropimorph 62.5 µM 0.0647054932753644 0.480997970498228 no 1602 0.474204244494798 2274 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_433 pimozide 108 µM 0.0644446495979121 0.48110379893364 no 1603 0.474308089326795 2284 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_981 1488-1094 54.9 µM 0.0639289329879247 0.481313037290309 no 1604 0.474513407100141 2298 3449522 SGTC_2958 9077254 16.72 µM 0.0632733047940152 0.481579048491879 no 1605 0.474774436422831 2222 16457351 SGTC_18 0111-0177 500 nM 0.0630421900899228 0.481672821741132 no 1606 0.474866454141786 2287 721752 SGTC_3181 9108277 49.47 µM 0.0624007118513398 0.481933102553829 no 1607 0.475121864045543 2271 17097298 SGTC_190 3970-0790 3.722 µM 0.0622052887889274 0.482012397306871 no 1608 0.47519967540217 2313 2832352 SGTC_3160 9100216 49.47 µM 0.0620464379710685 0.482076853050764 no 1609 0.475262925530949 2308 17191039 SGTC_2153 5569715 200 µM 0.0615202688809381 0.482290356201815 no 1610 0.475472436372805 2295 2054701 SGTC_2029 5175081 200 µM 0.0613552374482247 0.482357321904727 no 1611 0.47553815025001 2292 1380876 SGTC_2693 st077581 40.7 µM 0.0613028874645553 0.482378564346683 no 1612 0.475558995632598 2318 25238761 SGTC_1801 st050089 28.441 µM 0.0602982168579116 0.482786246627633 no 1613 0.475959061052507 2294 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2869 9037858 32.47 µM 0.0595731411668616 0.48308048413115 no 1614 0.476247805303892 2314 27187042 SGTC_1714 st033236 13.627 µM 0.0592402424750889 0.483215578337552 no 1615 0.476380378524275 2270 2916566 SGTC_3064 1327-0027 10 µM 0.0590418476282391 0.483296090218354 no 1616 0.476459388321045 2246 16000455 YPR107C YTH1 SGTC_1201 1889-3372 45.9 µM 0.0571831813157901 0.484050400111278 no 1617 0.477199637800933 2206 5392199 SGTC_1879 gemcitabine 100 µM 0.0562794398058278 0.484417189892168 no 1618 0.477559598764585 2280 60750 A nucleoside analog which inhibits DNA replication. SGTC_1278 0874-0585 172 µM 0.0541795037016076 0.485269513961609 no 1619 0.478396075186159 2263 766306 SGTC_876 0720-0963 56.8 µM 0.0536603108279616 0.485480254988214 no 1620 0.478602902294124 2316 765861 SGTC_1492 4158-0558 28.5 µM 0.0536293187863328 0.485492834824912 no 1621 0.478615248552277 2294 3967268 SGTC_1221 2958-7315 257 µM 0.0508308259788336 0.486628816111349 no 1622 0.479730163520542 2273 4562705 SGTC_1637 st007924 17.4 µM 0.0507824242647631 0.486648464611767 no 1623 0.479749448104883 2316 683336 SGTC_1165 k072-0275 30.3 µM 0.0500208431579428 0.486957629938387 no 1624 0.480052889336523 2305 6153523 YGL055W OLE1 SGTC_424 splitomicin 100 mM 0.0483090032193945 0.487652583009194 no 1625 0.480734989700755 2142 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1461 k072-0203 53.8 µM 0.0482959014413972 0.487657902065464 no 1626 0.480740210460046 2304 5418714 SGTC_748 act1.228 77.9 µM 0.0468203502175699 0.488256959771859 no 1627 0.481328204845112 2296 4421505 YNR035C ARC35 SGTC_129 0088-0017 176.636 µM 0.0465081707969333 0.488383704653659 no 1628 0.481452610890415 2330 182446 SGTC_161 4065-0411 162.148 µM 0.046359211301881 0.488444182640547 no 1629 0.481511973101431 2278 1906281 YLR208W SEC13 SGTC_804 1595-0054 20.9 µM 0.0457956278336606 0.488673001555536 no 1630 0.481736571819892 2247 761523 Stimulates phospholipase C. SGTC_1982 st072467 71.9 µM 0.0454282687686592 0.488822153972647 no 1631 0.481882974511224 2218 3163533 SGTC_913 3487-1245 167 µM 0.0454274371178461 0.488822491635155 no 1632 0.481883305949727 2292 4016153 SGTC_1788 fluconazole 20 µM 0.0452099484502097 0.488910795519443 no 1633 0.481969982321599 2200 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1708 st033234 31.827 µM 0.0450091361854402 0.488992328999688 no 1634 0.482050013356459 2305 674664 SGTC_1730 st033808 45.1 µM 0.0447568896360796 0.489094746398781 no 1635 0.482150543860217 2133 1045166 SGTC_1812 st052057 4.327 µM 0.0434313938711244 0.489632937189796 no 1636 0.482678826306981 2324 3645418 SGTC_2884 9058502 51.95 µM 0.0423776160008103 0.490060815932666 no 1637 0.48309883607996 2286 6471554 SGTC_1624 st003710 6.25 µM 0.041724611783555 0.490325969257069 no 1638 0.483359116838385 2317 24207033 SGTC_3212 9128307 49.47 µM 0.041644236434128 0.49035860608397 no 1639 0.483391154117622 2180 27243542 SGTC_2561 acetosyringone 100 µM 0.0415034088764393 0.490415789998624 no 1640 0.4834472876535 2347 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2581 avocatin a 64 µM 0.0414449130860535 0.490439542639828 no 1641 0.483470604035556 2301 6710728 A skin care supplement. SGTC_1049 3226-0134 66 µM 0.0401072462417936 0.490982721077464 no 1642 0.484003812393043 2320 5702385 SGTC_850 0388-0143 75.9 µM 0.0400967678451949 0.490986976045116 no 1643 0.48400798930853 2316 67273 SGTC_255 tunicamycin 200.472 nM 0.0397452177637685 0.491129730750671 no 1644 0.484148125787717 2329 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2893 9048488 25.97 µM 0.0387680864914305 0.491526522480775 no 1645 0.484537644493939 2309 6467338 SGTC_1387 3342-1166 1.8 µM 0.0387433952294871 0.491536549174804 no 1646 0.484547487487383 2272 3418228 SGTC_2050 5263056 171 µM 0.0375257454095183 0.492031022195319 no 1647 0.485032906365874 2336 763468 YGL055W OLE1 SGTC_2504 purpurogallin 52.29 µM 0.0374986848407642 0.492042011310373 no 1648 0.485043694377947 2257 5281571 An antioxidant. SGTC_1350 1495-0454 146 µM 0.0370896813182714 0.492208105622045 no 1649 0.485206749742056 2325 1069057 SGTC_1109 tnp00067 928.257 nM 0.0368022632026907 0.49232482551007 no 1650 0.485321334748881 2289 676295 SGTC_2767 sibutramine 71.45 µM 0.036112548130924 0.492604920001579 no 1651 0.485596308446653 2340 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_417 st075190 100 µM 0.0337397624000741 0.493568539408863 no 1652 0.486542335600092 2351 222757 SGTC_518 1021-0119 62.6 µM 0.0336190451818031 0.493617565305394 no 1653 0.486590467496602 2200 1097762 SGTC_2013 4024628 200 µM 0.0324952488506763 0.494073968045669 no 1654 0.487038552449175 2315 5230760 SGTC_1003 4049-0218 100 µM 0.0320276705492823 0.494263866000293 no 1655 0.487224992152664 2325 295161 SGTC_2237 6667747 47.222 µM 0.0318258227805285 0.494345843002469 no 1656 0.487305476731578 2221 729940 YDL015C TSC13 SGTC_3176 9106582 49.47 µM 0.0317897037128537 0.494360512166323 no 1657 0.487319878867394 2341 17018027 SGTC_1229 0139-0193 12.2 µM 0.0314097616860471 0.494514819814746 no 1658 0.487471378146912 2353 3090752 SGTC_855 0428-0020 25 µM 0.0305639589979328 0.494858332565403 no 1659 0.487808642632919 2288 6812414 SGTC_1200 1643-0193 18.4 µM 0.0297873943679855 0.495173728461604 no 1660 0.488118306072047 2347 5403974 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0288562650443306 0.495551903608146 no 1661 0.488489613260718 2359 4114 Related to psoralen; DNA damaging agent. SGTC_2764 methyldopa 94.69 µM 0.028775129349157 0.495584856801104 no 1662 0.488521968284268 2357 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2180 6301957 200 µM 0.028392918187234 0.49574009193797 no 1663 0.488674386196899 2349 845462 SGTC_1345 1488-0192 31.4 µM 0.0272633768197625 0.496198859061902 no 1664 0.489124833533624 2343 658348 SGTC_259 usnic acid 108.925 µM 0.0271106683205847 0.496260882544946 no 1665 0.489185732899902 2351 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0269495489381031 0.496326322257209 no 1666 0.489249986756614 2363 66535 A nucleotide analog. SGTC_2552 juarezic acid 87.02 µM 0.0264433932749426 0.496531901392006 no 1667 0.489451841704973 2357 1549512 SGTC_2003 4023581 200 µM 0.0259196183906517 0.496744637682097 no 1668 0.489660726044967 2317 16641307 SGTC_39 0986-0283 58.349 µM 0.025482181016268 0.496922307860396 no 1669 0.489835180680926 2353 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_781 4335-2806 94.4 µM 0.0247637908774987 0.497214091516144 no 1670 0.490121686444554 2350 845254 SGTC_2571 chrysanthemic acid 100 µM 0.0241280938991332 0.497472289499038 no 1671 0.490375217075689 2311 2743 An insecticide. SGTC_2645 abamectin 100 µM 0.0207027572221274 0.49886355751606 no 1672 0.491741384773557 2355 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_276 colchicine 750 µM 0.0203889986577532 0.498990997689446 no 1673 0.49186652991347 2294 2833 A microtubule depolymerizer. SGTC_3067 9117431 49.47 µM 0.0201381689747483 0.499092877941828 no 1674 0.491966575936739 2356 17150885 SGTC_2086 5274770 176.623 µM 0.0183518231857391 0.499818444742554 no 1675 0.492679092745075 2354 689278 SGTC_144 4161-2749 112.381 µM 0.0181817307586142 0.499887531893705 no 1676 0.492746938485586 2360 797501 YMR168C CEP3 SGTC_2882 9058044 58.44 µM 0.0179048345226926 0.5 no 1677 0.492857386120895 2358 18076804 SGTC_3114 9122766 49.47 µM 0.0176196728116638 0.499884174671083 no 1678 0.492971131239216 2292 17176985 SGTC_1 0258-0098 57.368 µM 0.0174605541181409 0.499819544767175 no 1679 0.493034600649487 2300 6790032 YDR047W HEM12 SGTC_3304 9125678 46.087 µM 0.0167015430057638 0.499511254150066 no 1680 0.493337358096429 2366 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1767 st044992 70.3 µM 0.0163245635253831 0.499358134964951 no 1681 0.493487730645845 2368 9600693 SGTC_3303 9125618 40.5795 µM 0.0150257227442619 0.498830580744371 no 1682 0.494005829457562 2355 22695467 SGTC_2904 7225135 42.03 µM 0.0134297167185297 0.498182328884008 no 1683 0.494642479232304 2375 4446116 SGTC_472 calcifediol 10 µM 0.012358978079494 0.49774742815165 no 1684 0.495069606616801 2340 5283731 A vitamin D metabolite. SGTC_98 0074-0023 107.663 µM 0.0115311856351274 0.497411206415298 no 1685 0.495399824453425 2369 3563821 SGTC_3302 9125395 16.351 µM 0.0107518041424929 0.497094649272495 no 1686 0.495710733377918 2359 17599668 SGTC_2634 4'-methoxyflavone 100 µM 0.00980880273541375 0.496711637983133 no 1687 0.496086916616822 2366 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1295 1013-0063 9.78 µM 0.00963919031059794 0.496642748181486 no 1688 0.49615457898526 2384 6826038 SGTC_25 0118-0223 35.662 µM 0.00935278223719171 0.496526420874324 no 1689 0.496268834123276 2388 5333628 SGTC_2132 5317594 122.667 µM 0.00909385417678368 0.496421255084376 no 1690 0.496372127080228 2383 794577 SGTC_1324 1418-0026 34.4 µM 0.00901392668381875 0.496388791916792 no 1691 0.496404012229644 2333 1372513 SGTC_835 0312-0010 67.2 µM 0.00869413090514431 0.496258904636756 no 1692 0.496531587285661 2392 1626196 SGTC_2293 7624732 200 µM 0.00828534901627315 0.496092875608397 no 1693 0.496694661786499 2387 894453 SGTC_3334 9142812 21.919 µM 0.00732968469684034 0.495704729942242 no 1694 0.497075905054924 2373 45283678 SGTC_2873 9040596 71.43 µM 0.00673807351539781 0.49546444746398 no 1695 0.497311917926823 2344 6463863 SGTC_1719 st032227 49.2 µM 0.00587854865248593 0.495115354981895 no 1696 0.497654811902376 2394 3125804 SGTC_2906 7926292 26.41 µM 0.00549301041997173 0.494958771416291 no 1697 0.497808616916953 2383 2966319 SGTC_613 3914-0030 117 µM 0.00519465674643936 0.494837597760802 no 1698 0.497927641111924 2379 1145395 SGTC_3211 9128781 49.47 µM 0.00491259781692309 0.494723042506551 no 1699 0.49804016490721 2370 17194361 SGTC_1893 st059353 36.1 µM 0.00422708277931067 0.494444629649297 no 1700 0.498313642978613 2395 3112488 SGTC_2140 5586273 200 µM 0.00306759011766251 0.493973723285201 no 1701 0.498776210522455 2402 854421 SGTC_2115 tiliquinol 12.7705 µM 0.0026810736186814 0.493816748636821 no 1702 0.498930407658039 2395 71208 A bioactive hydroxyquinoline. SGTC_611 3453-1652 23.7 µM 0.00266405827764423 0.493809838275303 no 1703 0.498937195772751 2399 1560575 SGTC_11 0438-0307 1.3 µM 0.000580301561622442 0.492963586504993 no 1704 0.499768493184679 2404 4011476 SGTC_1314 1222-0010 41.1 µM 0.000558238404448867 0.49295462641544 no 1705 0.499777295109488 2403 3526027 SGTC_171 k064-0041 9.68 µM 0.00037227519213692 0.492879104861718 no 1706 0.499851483689342 2397 53325 SGTC_1692 fluoroquinolonic acid 71 µM 5.0475395774673e-06 0.492729970725703 no 1707 0.499997986323051 2404 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1260 0700-1617 7.75 µM -0.00116489448273156 0.492254854633291 no 1708 0.499535274443736 2407 2853078 SGTC_1629 st005085 44.9 µM -0.00134361676741252 0.492182276061328 no 1709 0.499463974624104 2409 24207091 SGTC_2359 9039622 200 µM -0.00159301592966448 0.492080996259136 no 1710 0.499364478861097 2408 6463596 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.00258677078470925 0.491677442318756 no 1711 0.498968028915158 2414 1609 A potent and irreversible inhibitor of serine proteases. SGTC_474 dl-dihydrosphingosine 5 µM -0.00288237552327567 0.491557401806321 no 1712 0.498850100128016 2419 3058739 A sphingolipid protein kinase C inhibitor. SGTC_300 r073-0011 5.04 µM -0.00506384935141595 0.490671563380053 no 1713 0.497979825025887 2418 2735780 SGTC_484 loperamide 105 µM -0.00543964683985121 0.490518966551802 no 1714 0.497829905587231 2409 3955 An opioid-receptor agonist. SGTC_3199 9111318 49.47 µM -0.00607683499993397 0.490260232262573 no 1715 0.497575708508187 2419 8548020 SGTC_648 0375-0473 33.3 µM -0.00740873624187919 0.489719418689452 no 1716 0.497044368907586 2418 1713139 SGTC_2953 9074162 66.49 µM -0.00891563931892671 0.489107569109475 no 1717 0.496443221639503 2420 16451992 SGTC_3115 9123671 49.47 µM -0.0119521368813518 0.487874735875598 no 1718 0.495231900780491 2424 3286988 SGTC_691 1548-0686 185 µM -0.0121582532580653 0.487791055659654 no 1719 0.495149678218109 2441 46495133 SGTC_289 k017-0060 526 µM -0.0152606086202125 0.48653161204531 no 1720 0.493912134294283 2445 5512909 SGTC_2195 6536160 144.242 µM -0.0174161534074266 0.485656617473957 no 1721 0.493052311277198 2439 3834386 SGTC_2883 9059145 45.46 µM -0.0177444645541577 0.485523352957338 no 1722 0.492921354319046 2434 16476510 SGTC_1729 st035615 45.989 µM -0.0180132394107801 0.485414255971834 no 1723 0.492814145801303 2506 17385451 SGTC_2277 7947813 106.88 µM -0.01804953507956 0.4853995234717 no 1724 0.492799668278169 2532 1246798 SGTC_1367 1812-0510 76.9 µM -0.0180534027715417 0.485397953567303 no 1725 0.492798125543685 2449 1142582 YDR527W RBA50 SGTC_2675 theaflavin digallate 100 µM -0.0182164234213585 0.485331783345126 no 1726 0.492733100407419 2460 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1317 1273-0028 910 nM -0.0190116156507176 0.48500901995818 no 1727 0.492415919567878 2452 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1842 st055362 61.2 µM -0.0190413052512319 0.484996969330082 no 1728 0.492404077274631 2453 676032 SGTC_1961 st076550 68.7 µM -0.0191421742060607 0.48495602801732 no 1729 0.492363843716911 2460 1579337 SGTC_2782 7736369 71.43 µM -0.0200181644171621 0.484600482429606 no 1730 0.492014441179575 2456 2950836 YOL077C BRX1 SGTC_1985 st071382 65.5 µM -0.0207770179203489 0.484292489999245 no 1731 0.491711765412235 2443 6123237 SGTC_3270 9137563 49.47 µM -0.0213748909177817 0.484049840587877 no 1732 0.491473301567008 2540 17015724 SGTC_3221 9128209 49.47 µM -0.0222070711102076 0.48371210641311 no 1733 0.491141388526199 2465 16460723 SGTC_1396 3511-0007 98.6 µM -0.0222221980783381 0.483705967352409 no 1734 0.491135355227907 2472 X1396 SGTC_2151 5563267 85.4165 µM -0.0222881539019111 0.483679200182815 no 1735 0.491109049176656 2452 5310824 SGTC_2442 5158906 48.48 µM -0.0243390347484239 0.482846918635745 no 1736 0.49029108855892 2479 1893835 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0245375266652056 0.482766371224671 no 1737 0.490211925383952 2464 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1955 wogonin 32.4 µM -0.025230926864407 0.482484997092327 no 1738 0.489935384366566 2535 5281703 A flavanone. SGTC_451 chloral hydrate 100 µM -0.0253023970157228 0.482455995788879 no 1739 0.489906881001212 2484 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_457 grayanotoxin iii 135 µM -0.0253096720201046 0.482453043727999 no 1740 0.489903979623537 2480 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2242 6630449 61.2675 µM -0.0253423039356782 0.482439802318065 no 1741 0.489890965547045 2580 691249 YDR170C SEC7 SGTC_3071 9117417 49.47 µM -0.0259488093263205 0.482193697521479 no 1742 0.489649084462151 2470 45595590 YGL055W OLE1 SGTC_2586 curcumin 80 µM -0.0262354442754944 0.482077390546433 no 1743 0.489534772580612 2469 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_234 nsc-17383 10.7 µM -0.0278561841678448 0.48141977692824 no 1744 0.488888427418979 2461 408974 SGTC_744 1594-0068 283 µM -0.0300151056165439 0.480543875503392 no 1745 0.488027503029353 2461 668392 SGTC_1275 0867-0008 21.1 µM -0.0303872402433644 0.480392905205264 no 1746 0.487879110484227 2466 3422836 SGTC_2316 5844804 197.44 µM -0.0309323485440644 0.480171766764578 no 1747 0.487661745926224 2457 776813 SGTC_3012 9080433 71.4286 µM -0.0309363049745471 0.480170161750029 no 1748 0.48766016829385 2459 17688859 SGTC_2150 5556613 200 µM -0.0309808196020081 0.480152103417572 no 1749 0.487642418035112 2482 743190 SGTC_570 0987-0065 62.6 µM -0.0320625562395043 0.479713285896595 no 1750 0.487211081919823 2464 3104428 SGTC_2638 epoxomicin 18 µM -0.0322584192141689 0.479633834692762 no 1751 0.487132984296701 2486 9915668 A protesome inhibitor. SGTC_2965 9082772 38.63 µM -0.0322830268588012 0.479623852735739 no 1752 0.487123172377231 2480 16459634 SGTC_156 3474-0145 5.642 µM -0.0327367949520479 0.479439786477063 no 1753 0.486942240738966 2443 2265471 SGTC_2488 5268135 45.7 µM -0.0333682530697247 0.479183649431669 no 1754 0.486690462969019 2497 1270356 YLR208W SEC13 SGTC_752 1896-0090 130 µM -0.0344832447843576 0.47873139871293 no 1755 0.486245901563804 2467 772567 SGTC_1439 4092-1168 46 µM -0.0348873824378305 0.478567483558098 no 1756 0.486084770922785 2482 2886240 SGTC_1539 benzyladenosine 56 µM -0.0361167900945161 0.478068867577252 no 1757 0.485594617251271 2466 92208 A nucleotide analog. SGTC_439 amiodarone 34.4 µM -0.0368604954278597 0.477767256522569 no 1758 0.485298119204053 2541 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_779 1360-0071 233 µM -0.0376775992665486 0.477435893257303 no 1759 0.484972368254039 2494 7566 SGTC_2683 piperine 63.03 µM -0.0389413365576223 0.476923435810972 no 1760 0.484468579870258 2475 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.040783414866375 0.476176524183693 no 1761 0.483734280688646 2490 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_319 1348-1596 45.5 µM -0.0408507038068635 0.476149241954528 no 1762 0.483707458637798 2550 5380505 SGTC_1503 4585-0012 61.3 µM -0.0411415472592251 0.476031321074603 no 1763 0.483591526351698 2545 2922052 SGTC_2598 perillyl alcohol 100 µM -0.0411683366205038 0.476020459580672 no 1764 0.483580847989776 2520 10819 An apoptosis inducer. SGTC_1925 st057770 10.1 µM -0.0415502751516198 0.475865608146274 no 1765 0.483428606829094 2492 5989122 SGTC_1091 telmisartan 47.6 µM -0.0432738390088976 0.47516685987215 no 1766 0.482741622564013 2560 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1497 4476-2978 41.3 µM -0.0438669299774507 0.474926433017628 no 1767 0.482505237984206 2545 1528379 SGTC_826 1683-5028 118 µM -0.0441367694755699 0.474817048663504 no 1768 0.482397691763716 2518 722377 SGTC_2094 5332512 191.667 µM -0.044156235225866 0.474809157940474 no 1769 0.482389933616567 2523 755774 SGTC_1831 st055328 12 µM -0.0445848714386735 0.474635406570612 no 1770 0.482219100755724 2491 1103068 SGTC_951 1171-0579 82.7 µM -0.0447958600108523 0.474549882310666 no 1771 0.482135012507433 2468 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3308 9128332 17.569 µM -0.0490896695401099 0.47280964606152 no 1772 0.480423917997989 2518 17332805 YDL196W YDL196W SGTC_1778 st046819 58.9 µM -0.0501722689895268 0.472370960384005 no 1773 0.479992554927114 2501 671715 SGTC_2214 7179297 48.276 µM -0.0507060775525897 0.472154665380499 no 1774 0.479779866847297 2485 769744 SGTC_3138 9097216 49.47 µM -0.0517316171974274 0.471739147932324 no 1775 0.479371272040023 2480 25237486 SGTC_338 4055-0136 114 µM -0.0560106145193655 0.470005765516461 no 1776 0.477666675636716 2499 2900563 SGTC_1473 k844-0725 134 µM -0.057609867372618 0.469358067024724 no 1777 0.477029694851079 2492 54682906 SGTC_383 2324-0395 7.37 µM -0.0579978571055774 0.469200943075378 no 1778 0.476875167718684 2583 3146421 SGTC_2657 nystatin 74.44 µM -0.0584799826049049 0.469005703712005 no 1779 0.476683153385074 2547 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1694 st024011 44.9 µM -0.0596290757553927 0.468540402279968 no 1780 0.476225530230533 2517 2787533 SGTC_149 3970-0822 46.1 µM -0.0596781087406343 0.468520548341255 no 1781 0.47620600367364 2514 3114250 YBL034C STU1 SGTC_1486 3970-0793 4.53 µM -0.0610547488642905 0.467963165331012 no 1782 0.475657803526804 2590 2844330 SGTC_2605 digitonin 300 nM -0.0629733772180307 0.46718644359169 no 1783 0.474893852067183 2520 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1798 st045719 60.953 µM -0.0654664941486402 0.46617733769314 no 1784 0.473901291441203 2509 3980186 SGTC_2752 diclazuril 33.15 µM -0.067302492589819 0.465434343572612 no 1785 0.473170446295277 2563 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3225 9130819 49.47 µM -0.0675725434872957 0.465325069143046 no 1786 0.473062956275416 2532 4547121 SGTC_1765 st044815 90.4 µM -0.0676054115408714 0.465311769466266 no 1787 0.473049873735611 2588 645695 SGTC_1388 3346-4487 254 µM -0.0678264166631895 0.465222343312956 no 1788 0.472961907362174 2576 3345614 SGTC_446 go6976 132 µM -0.0693284145726909 0.464614630876837 no 1789 0.472364104293698 2533 3501 A protein kinase C inhibitor. SGTC_2819 7996655 46.38 µM -0.0697150238508098 0.464458221011555 no 1790 0.472210241786743 2557 6456960 SGTC_2287 7945887 168.79 µM -0.0698007844726285 0.464423525724482 no 1791 0.472176111391892 2559 1245853 SGTC_674 0498-0004 451 µM -0.0702297872809775 0.464249972565275 no 1792 0.472005383015027 2552 4231473 SGTC_2286 7945697 125 µM -0.0707893423067397 0.464023614711136 no 1793 0.471782707076194 2573 1245733 SGTC_794 k038-0031 316 µM -0.071896579302995 0.463575736421337 no 1794 0.471342106163653 2517 6624242 SGTC_2415 st077333 57.7 µM -0.0728329112252697 0.463197025376549 no 1795 0.470969540562159 2528 2766255 SGTC_3215 9129942 49.47 µM -0.0731451493939808 0.463070744179663 no 1796 0.470845306917805 2563 17682944 SGTC_1774 st048371 48.465 µM -0.0731492739849873 0.463069076060343 no 1797 0.470843665840246 2540 4242727 SGTC_1679 SEC14.276 6.7 µM -0.07328009344715 0.463016168734117 no 1798 0.47079161611625 2613 1005053 YMR079W SEC14 SGTC_1169 aniline yellow 25.8 µM -0.0736163664482401 0.462880172820033 no 1799 0.470657823966536 2580 6051 A DNA damaging agent. SGTC_763 3453-1109 128 µM -0.0737243339142978 0.462836509412501 no 1800 0.4706148679059 2532 1560353 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0742571337001274 0.462621045013638 no 1801 0.47040289258481 2587 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2798 7813637 45.45 µM -0.0749587845204164 0.462337313945108 no 1802 0.470123752390021 2615 956368 SGTC_2610 ononetin 44.17 µM -0.0750121447414965 0.46231573711056 no 1803 0.470102524505999 2588 259632 SGTC_944 3370-0224 231 µM -0.076640814327394 0.461657219005507 no 1804 0.469454644641443 2555 4580514 SGTC_2062 5245942 200 µM -0.076774140864443 0.461603315869562 no 1805 0.469401611303558 2524 1376160 SGTC_1410 3909-8106 77.9 µM -0.0770938672210952 0.461474055256844 no 1806 0.46927443586533 2583 1039210 SGTC_1036 k216-0215 33.5 µM -0.0773453418099525 0.461372390677764 no 1807 0.469174410683098 2537 622330 SGTC_1078 idebenone 36.1 µM -0.0790285648162345 0.460691973089414 no 1808 0.468504951337163 2612 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_896 0964-0007 44.5 µM -0.0791355408081397 0.460648733521447 no 1809 0.468462407333723 2526 6756758 SGTC_2104 5389443 200 µM -0.0794879795809718 0.4605062814854 no 1810 0.468322246132563 2648 2244536 SGTC_3037 9091026 49.47 µM -0.0800176355655308 0.460292209658667 no 1811 0.46811161489608 2579 25236398 YIL048W NEO1 SGTC_2463 5473429 200 µM -0.0813409061807943 0.459757431885407 no 1812 0.467585421661278 2627 5399405 SGTC_1076 itraconazole 331 nM -0.0820982112050951 0.459451412366889 no 1813 0.467284307787769 2535 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2103 5378138 10 µM -0.0822597109917313 0.459386154991747 no 1814 0.467220095884903 2550 244142 SGTC_2669 eugenol 100 µM -0.0825632131747361 0.459263521532668 no 1815 0.46709942650097 2534 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1756 st041558 35.5 µM -0.0832747261628469 0.458976041949551 no 1816 0.466816548039679 2606 3955792 SGTC_2891 9063876 19.48 µM -0.0848477233512314 0.458340564791883 no 1817 0.466191226278402 2556 6472478 SGTC_2838 9002687 71.43 µM -0.0851515031991093 0.458217852595596 no 1818 0.466070472660947 2553 6457060 SGTC_2334 9017922 200 µM -0.0856281281916481 0.458025327447073 no 1819 0.465881018755936 2662 3163164 SGTC_780 0109-0199 192 µM -0.0858767742688494 0.457924894691657 no 1820 0.465782187369435 2618 610414 SGTC_1892 st058411 7.36 µM -0.0865371541544454 0.45765816808519 no 1821 0.465519711045852 2582 3934738 SGTC_3155 9099265 49.47 µM -0.0872691250589756 0.457362548242855 no 1822 0.465228797499323 2630 25236499 SGTC_1134 3477-0009 42.5 µM -0.0873963873245926 0.457311153451086 no 1823 0.465178220444994 2709 3973534 SGTC_886 0866-0150 153 µM -0.087981861962843 0.457074719070304 no 1824 0.464945546143725 2608 271463 SGTC_2704 st078022 71.1 µM -0.0894992033838062 0.456462036408847 no 1825 0.46434259332596 2632 54697681 SGTC_2434 5670830 169.91 µM -0.090553474379077 0.456036396390001 no 1826 0.463923701021344 2645 1549830 SGTC_1560 lithocholic acid 53.1 µM -0.0909589809903655 0.455872694924364 no 1827 0.463762592160464 2575 9903 A bile acid which acts as a detergent. SGTC_758 0868-0029 16 µM -0.0912670603308413 0.455748329480665 no 1828 0.463640195385627 2584 762687 SGTC_75 0159-0059 199.013 µM -0.0920079723852726 0.455449255936793 no 1829 0.463345852707577 2615 5377270 SGTC_2925 9010536 32.5 µM -0.0924579660143768 0.455267625652037 no 1830 0.463167093190375 2631 2994177 SGTC_366 0181-0206 4.31 µM -0.0931031552149518 0.455007225180804 no 1831 0.462910805413538 2599 274874 SGTC_1336 1486-0901 104 µM -0.0934317166872848 0.454874624118168 no 1832 0.462780297220611 2651 5006114 SGTC_2944 9067346 25.62 µM -0.0939813354638513 0.454652819845918 no 1833 0.462561991623626 2652 6473075 SGTC_1753 st043925 64 µM -0.0952612343260229 0.454136358499275 no 1834 0.462053666553253 2588 670181 SGTC_1000 4048-0884 8.67 µM -0.0954653486875549 0.454054001967206 no 1835 0.461972606131926 2691 13040088 SGTC_431 k089-0097 107 µM -0.0966616056881538 0.453571373270956 no 1836 0.461497565611401 2564 5499420 SGTC_1488 4013-0813 75.9 µM -0.098647126640791 0.452770468494687 no 1837 0.460709225413572 2566 2910057 SGTC_1276 0871-0068 94.2 µM -0.0991798696398289 0.452555607111249 no 1838 0.46049772887236 2668 3414906 SGTC_2740 felodipine 17.08 µM -0.0992337413628825 0.452533880797653 no 1839 0.460476342665112 2638 3333 L-type calcium channel blocker SGTC_2465 5809242 33.21 µM -0.100571007330945 0.451994610927303 no 1840 0.459945506391824 2593 2731748 SGTC_2917 7979103 53.79 µM -0.101326211268094 0.451690104195091 no 1841 0.459645754843099 2676 2980565 SGTC_1094 duloxetine 25.4 µM -0.101706282985783 0.451536865738079 no 1842 0.459494907454789 2568 60834 A selective serotonin reuptake inhibitor. SGTC_3096 9117468 49.47 µM -0.104132327525352 0.45055889692159 no 1843 0.458532168325753 2593 41316311 SGTC_2564 betulinic acid 100 µM -0.104653739243306 0.450348748332379 no 1844 0.458325285519795 2672 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_3180 9109287 49.47 µM -0.104794179330073 0.450292148057379 no 1845 0.458269564420297 2691 18891271 SGTC_330 1488-0319 80.1 µM -0.10588067139313 0.449854303417417 no 1846 0.457838514923106 2660 6846614 SGTC_1198 1612-1005 86.7 µM -0.106066114834136 0.44977957778447 no 1847 0.457764947947747 2753 6998509 SGTC_966 1300-0360 30.2 µM -0.106495671965162 0.449606491806817 no 1848 0.457594544577075 2612 70588 SGTC_2200 6600604 21.907 µM -0.106897735967434 0.449444492610911 no 1849 0.457435054668293 2591 2904777 SGTC_664 1222-0054 14.9 µM -0.107145724580823 0.449344577504798 no 1850 0.457336686479197 2625 6813991 SGTC_695 3505-6186 243 µM -0.109521003568061 0.448387736487151 no 1851 0.456394631767293 2699 1819379 SGTC_1031 k035-0009 16 µM -0.109968256136716 0.44820760175818 no 1852 0.456217275063151 2783 5180959 SGTC_1824 st053723 68.6 µM -0.110045469311849 0.448176504583197 no 1853 0.45618665728528 2644 675225 SGTC_933 2914-0560 114 µM -0.111387696312337 0.447635981205645 no 1854 0.45565445813288 2667 463887 SGTC_2061 5245884 80.95 µM -0.111705870897119 0.447507864488457 no 1855 0.455528312083085 2621 573863 SGTC_829 1635-0120 117 µM -0.112432658926209 0.447215235353519 no 1856 0.455240180704814 2736 285054 SGTC_2890 9046729 58.44 µM -0.11394340368126 0.446607051175465 no 1857 0.454641329218592 2654 903329 SGTC_2222 6885208 172.143 µM -0.114257591682379 0.446480583475335 no 1858 0.454516799606298 2633 609514 SGTC_384 k007-0144 5.16 µM -0.114272456803908 0.44647460006609 no 1859 0.454510907869357 2682 6824886 SGTC_347 4534-1311 26.2 µM -0.114346121195527 0.44644494934797 no 1860 0.45448171140293 2582 2862016 SGTC_1874 staurosporine 7.6 µM -0.11533286804891 0.446047801950773 no 1861 0.454090643622022 2710 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2746 daunorubicin 9.88 µM -0.115761933482522 0.445875127892314 no 1862 0.45392061015347 2591 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1978 st071761 42 µM -0.116346793945615 0.445639771870798 no 1863 0.453688850597114 2626 5147680 SGTC_2986 9022445 71.43 µM -0.116597967369251 0.445538702050757 no 1864 0.453589324271536 2624 6459286 SGTC_208 k072-0098 12.366 µM -0.116719036997646 0.44548998603634 no 1865 0.453541352023178 2630 5948901 SGTC_2502 avocadyne acetate 18.59 µM -0.117908497969189 0.445011414438796 no 1866 0.453070079907712 2578 3952079 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.118952674013722 0.444591363277007 no 1867 0.452656425070553 2676 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_766 1391-0721 126 µM -0.119768741790593 0.444263118805195 no 1868 0.452333172050123 2774 1020919 YIL115C NUP159 SGTC_2010 4012422 159 µM -0.119868880898442 0.444222842783578 no 1869 0.452293508069355 2684 952393 SGTC_1726 st035556 14.5795 µM -0.120063835682995 0.444144433480819 no 1870 0.452216290025434 2859 5919439 SGTC_2098 5376439 882.5 nM -0.120783091117111 0.443855173456354 no 1871 0.451931421688475 2724 2844116 SGTC_164 4100-3994 89.624 µM -0.123257048584483 0.442860461373247 no 1872 0.450951775839448 2614 4615967 SGTC_2476 5806916 10.51 µM -0.124513903336378 0.442355251242128 no 1873 0.450454196387167 2651 2870194 SGTC_379 3970-0972 5.9 µM -0.124620633441234 0.442312353908363 no 1874 0.450411946308002 2683 2898042 YBL034C STU1 SGTC_3347 9188721 44.724 µM -0.125100945105912 0.442119313757488 no 1875 0.450221817544818 2705 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_546 peri-Naphthalide 147 µM -0.125804992409181 0.441836377756946 no 1876 0.449943144902246 2726 223824 A penicillin ester. SGTC_1115 galangin 695.678 nM -0.126874213144635 0.441406746041379 no 1877 0.449519978304413 2634 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_371 0195-0006 7.36 µM -0.12713194689628 0.441303194374637 no 1878 0.449417983318475 2605 3928593 SGTC_3275 9138069 49.47 µM -0.128536463653015 0.440738961593981 no 1879 0.448862221859736 2709 17617007 SGTC_3342 9147791 14.508 µM -0.128627548261114 0.440702374557726 no 1880 0.448826183510277 2627 1838168 SGTC_2226 7298446 200 µM -0.129438878908907 0.44037650011214 no 1881 0.448505192752879 2663 3283010 SGTC_2066 5222451 176 µM -0.129655898970703 0.440289339906545 no 1882 0.44841933773785 2633 2281147 SGTC_1967 st070177 51.4 µM -0.129690746035231 0.440275344800277 no 1883 0.448405552162466 2756 5729214 SGTC_1942 st076330 65.2 µM -0.131172704120139 0.439680237379843 no 1884 0.447819344158564 2790 24208414 SGTC_2211 7117706 200 µM -0.131397918872941 0.439589810164962 no 1885 0.44773026744469 2645 822771 SGTC_1084 voriconazole 435 nM -0.132636068313754 0.439092730387157 no 1886 0.447240603015468 2651 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3208 9114115 49.47 µM -0.134628145902312 0.438293173000382 no 1887 0.44645294349029 2725 650895 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.13527545377638 0.438033417995164 no 1888 0.446197045859322 2606 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3098 9119039 49.47 µM -0.135711791123029 0.437858337375684 no 1889 0.446024562998641 2624 17161528 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.13599308996542 0.437745472494897 no 1890 0.445913371812091 2649 688664 SGTC_2682 pyrogallin 40.03 µM -0.13612716493599 0.437691679687772 no 1891 0.445860376449455 2667 822798 An ATP competetive kinase inhibitor. SGTC_1493 4348-0038 111 µM -0.13859098870301 0.436703364170078 no 1892 0.444886682280317 2659 800424 SGTC_591 4299-0174 154 µM -0.139079999783918 0.436507253558984 no 1893 0.444693466236791 2691 5509088 SGTC_237 nikkomycin 200 µM -0.144806436570021 0.434211925272752 no 1894 0.442431850073178 2796 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_298 1391-0729 10 µM -0.145150058365207 0.434074261026837 no 1895 0.442296197943902 2666 3237558 SGTC_2640 pentamidine 10.38 µM -0.145872639598334 0.433784801416253 no 1896 0.4420109654784 2758 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1755 st041960 45.185 µM -0.14674059744429 0.433437152182359 no 1897 0.441668386655294 2787 2257073 SGTC_846 0335-0850 148 µM -0.149292405381985 0.432415357916971 no 1898 0.440661453871849 2673 6819598 SGTC_142 0335-0849 62.6745 µM -0.150805970125341 0.431809509754088 no 1899 0.440064388326298 2693 3889043 YPR107C YTH1 SGTC_1423 4048-0112 5.59 µM -0.151045575255253 0.431713615520255 no 1900 0.439969882220281 2760 X1423 SGTC_610 4215-0184 155 µM -0.151414077045268 0.431566142405938 no 1901 0.439824542805257 2730 5605015 SGTC_2049 5262831 67.185 µM -0.15228644239995 0.431217062925646 no 1902 0.439480508799644 2720 763417 SGTC_662 k832-1615 104 µM -0.153327350664306 0.430800610832761 no 1903 0.439070066486393 2752 5878478 SGTC_867 0518-0118 155 µM -0.153473588074589 0.430742109548122 no 1904 0.439012408601289 2701 6848158 SGTC_937 3122-0005 46.7 µM -0.155682553412383 0.429858613520859 no 1905 0.438141624919107 2833 759535 SGTC_1451 4152-0210 104 µM -0.156073289188525 0.429702371570692 no 1906 0.437987626233922 2766 659563 SGTC_631 k072-0230 41.5 µM -0.157838091507007 0.428996824641821 no 1907 0.43729219108855 2795 5773147 SGTC_1386 3228-0095 33.8 µM -0.158204294006047 0.428850449588281 no 1908 0.437147910119981 2810 870181 SGTC_1428 4049-0204 61.7 µM -0.159501992804587 0.428331824415739 no 1909 0.436636694193473 2791 X1428 SGTC_2961 9083290 32.55 µM -0.159914622651883 0.428166942834599 no 1910 0.436474164774427 2670 17741490 SGTC_1378 2093-0007 380 nM -0.159928933333278 0.428161224695164 no 1911 0.436468528179266 2785 3618014 SGTC_123 0083-0120 66.675 µM -0.160351911948246 0.4279922213419 no 1912 0.436301934031079 2702 16001701 SGTC_2258 7960471 200 µM -0.160443213280132 0.427955743141777 no 1913 0.436265975615322 2743 2974708 SGTC_370 0180-0345 38.7 µM -0.16050349116103 0.427931660275182 no 1914 0.436242235865828 2641 3989527 SGTC_2281 7943571 200 µM -0.161066998688859 0.427706534691125 no 1915 0.436020316033978 2788 1244024 SGTC_2800 7887935 81.82 µM -0.162554648520206 0.427112320422873 no 1916 0.435434548585634 2849 2961002 SGTC_640 3381-0960 37.1 µM -0.163205394337159 0.426852443919091 no 1917 0.435178359544283 2736 1745025 SGTC_1613 st002381 52.1 µM -0.163206463986938 0.426852016778647 no 1918 0.435177938461291 2701 551167 SGTC_15 0266-0086 27.098 µM -0.164341757089407 0.426398711613698 no 1919 0.434731055570267 2739 1712902 YIL048W NEO1 SGTC_549 1661-1316 519 µM -0.166005807549767 0.425734457558162 no 1920 0.434076189913098 2763 2857282 SGTC_188 3229-0966 278.469 µM -0.166717997003784 0.425450230734834 no 1921 0.433795972082229 2723 5722370 SGTC_2743 auranofin 4.32 µM -0.167798580390828 0.425019056046854 no 1922 0.43337086967444 2737 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_334 1502-1024 68.5 µM -0.168278346994465 0.42482764815866 no 1923 0.433182153769061 2809 3296216 SGTC_2394 5221648 200 µM -0.16860058696466 0.424699097109483 no 1924 0.433055409420699 2823 788586 SGTC_2105 5350118 200 µM -0.169357545383285 0.424397155545837 no 1925 0.432757707474942 2741 2133313 SGTC_2110 5483698 200 µM -0.169461698068569 0.424355613766661 no 1926 0.432716748555212 2756 2848765 YHR062C RPP1 SGTC_493 zm226600 134 µM -0.169746790439495 0.424241907658375 no 1927 0.432604637280763 2873 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2556 citropten 84.59 µM -0.170070527220021 0.424112796277695 no 1928 0.432477335847275 2709 2775 A potential DNA crosslinker. SGTC_114 0364-0001 490.298 µM -0.170286185918821 0.424026792675036 no 1929 0.432392537318927 2764 4003655 SGTC_435 c-PAF 6.7 µM -0.17111941527083 0.423694539037249 no 1930 0.432064934927281 2786 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2274 7947094 46.08 µM -0.171594149055395 0.42350526122489 no 1931 0.431878303801812 2690 2971028 SGTC_1929 genistein trimethyl ether 50.5 µM -0.173169753428795 0.422877189674351 no 1932 0.43125899884942 2749 136420 SGTC_488 nitrendipine 139 µM -0.174441806530217 0.422370263432157 no 1933 0.430759130548152 2697 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1504 k297-0033 30 µM -0.174612852453212 0.422302109659995 no 1934 0.430691924473018 2677 4388117 SGTC_355 1311-2252 105 µM -0.174814991353872 0.422221569794843 no 1935 0.430612504167226 2739 5338538 SGTC_3290 9121031 71.43 µM -0.175070776551415 0.422119659856162 no 1936 0.430512010272366 2749 17014854 SGTC_975 1335-0046 28.5 µM -0.175388167504603 0.421993212202185 no 1937 0.430387318722883 2761 16486740 SGTC_1997 st073024 93.8 µM -0.175484089035326 0.421954998918593 no 1938 0.430349635950736 2725 686268 SGTC_856 0433-0016 11.3 µM -0.17554170390132 0.421932046622926 no 1939 0.430327002256242 2784 3911780 SGTC_2553 4-methylesculetin 85.09 µM -0.175827244517351 0.42181829842685 no 1940 0.430214832519797 2744 5319502 SGTC_3162 9099653 49.47 µM -0.176290950744003 0.421633589931382 no 1941 0.430032685479487 2729 25237511 SGTC_1810 st050138 53 µM -0.176323636267016 0.421620570929207 no 1942 0.430019846939361 2726 3444541 SGTC_579 4491-1009 110 µM -0.176400617040104 0.421589908981811 no 1943 0.429989609969078 2733 1271041 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.177853581663505 0.421011273001059 no 1944 0.429418983005227 2716 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1043 0916-0009 19.3 µM -0.178470996894642 0.420765442008627 no 1945 0.429176548320608 2765 3101130 SGTC_3014 9081533 49.47 µM -0.17992155755259 0.420188006280076 no 1946 0.42860707544667 2853 21367265 SGTC_1981 st071826 47 µM -0.180447265256695 0.419978776145797 no 1947 0.428400725477403 2823 11838600 SGTC_3259 9138485 49.47 µM -0.180797952787496 0.419839216101345 no 1948 0.428263085034366 2996 17646153 SGTC_1127 asiatic acid 681.4 nM -0.180811256334413 0.419833922003671 no 1949 0.428257863731304 2717 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_524 r073-0010 27.8 µM -0.181480610240879 0.419567573820695 no 1950 0.427995175616661 2713 2772106 SGTC_3348 9149464 3.537 µM -0.184041736560272 0.418548795962199 no 1951 0.426990356532433 2704 1951442 SGTC_1964 st076914 61 µM -0.184602974008611 0.418325616785024 no 1952 0.426770226558209 2715 24208661 SGTC_646 4092-0839 27.3 µM -0.187899751644807 0.4170151680262 no 1953 0.425477618714368 2864 877796 SGTC_1672 st016598 6.51 µM -0.188384628291803 0.416822509931562 no 1954 0.425287574407689 2793 4665860 YNL267W PIK1 SGTC_2814 7977482 42.97 µM -0.188479282296087 0.416784902983422 no 1955 0.425250477398611 2896 6456762 SGTC_1720 st037298 9.481 µM -0.189275025632525 0.416468776630883 no 1956 0.424938634090552 2827 597396 SGTC_466 geldanamycin 89.2 µM -0.189400571406906 0.416418905769238 no 1957 0.424889438327972 2794 5288382 HSP90 inhibitor. SGTC_1139 k015-0024 46.9 µM -0.189567026314659 0.416352786544917 no 1958 0.424824213913163 2735 2766652 SGTC_1740 st038286 13.222 µM -0.190513776564853 0.41597676344718 no 1959 0.424453274373019 2946 716786 SGTC_459 nigericin 15.3 µM -0.190676455077123 0.41591215976023 no 1960 0.424389543178505 2851 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_589 1227-0070 34.1 µM -0.191312266197417 0.415659685147679 no 1961 0.424140475772611 2868 2841384 SGTC_82 0054-0107 293.755 µM -0.191702324506847 0.415504813885938 no 1962 0.423987692533672 2818 3104697 SGTC_1195 1502-0147 41.1 µM -0.191834969254251 0.415452150751042 no 1963 0.423935739072441 2736 817940 SGTC_1141 3253-0389 52.6 µM -0.196137651500205 0.413744711899335 no 1964 0.422251213463411 2745 5402031 SGTC_1074 carmofur 3.8 µM -0.196142771339527 0.413742681151293 no 1965 0.42224920985646 2752 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1787 fluconazole 80 µM -0.196493456133785 0.413603590002246 no 1966 0.42211197704203 2789 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_337 1315-0038 354 µM -0.196522784961295 0.413591957880716 no 1967 0.422100500275932 2766 1626437 SGTC_2680 butyl paraben 22.24 µM -0.196930593429335 0.413430224614193 no 1968 0.421940926176415 2739 7184 An antifungal and steroid mimetic. SGTC_1509 1326-1131 80 µM -0.197513364501388 0.413199128209217 no 1969 0.421712912038452 2754 768313 SGTC_2608 thymoquinone 42.66 µM -0.197584243188388 0.413171023493444 no 1970 0.421685181937962 2722 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.198401328197927 0.412847066278206 no 1971 0.42136553917426 2925 6728940 SGTC_1764 st044502 93.5 µM -0.198612549598039 0.412763331030267 no 1972 0.42128291801314 2876 8407 SGTC_3148 9097893 49.47 µM -0.199717738736957 0.412325261791823 no 1973 0.420850669879688 2788 17174100 SGTC_3061 glucosamine 200 µM -0.19972806914852 0.412321167590254 no 1974 0.420846630023996 2761 91431 and experimental redox chemotherapeutic SGTC_1313 1220-0047 237 µM -0.20032964846783 0.412082763066664 no 1975 0.4206113881876 2805 3528706 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.200536847301032 0.412000658144562 no 1976 0.420530371625775 2830 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2079 5212404 121 µM -0.203300510793912 0.4109058943869 no 1977 0.419450078154245 2851 758462 SGTC_1987 st072290 61.9 µM -0.203575480073087 0.410797009228425 no 1978 0.419342627970394 2815 54697379 SGTC_2435 5706476 10.6 µM -0.204834970635979 0.410298351194566 no 1979 0.418850531822747 2905 5725375 SGTC_2903 5923464 63.88 µM -0.204841894727819 0.410295610205231 no 1980 0.418847826857739 2865 2876576 SGTC_3258 9138477 49.47 µM -0.205372182781609 0.410085702000709 no 1981 0.418640675988744 2791 4970355 SGTC_2458 5808907 16.39 µM -0.2057574904973 0.409933198690635 no 1982 0.418490174152296 2821 2731747 SGTC_2718 lomofungin 53.02 µM -0.206643867760207 0.409582425735112 no 1983 0.418143999044122 2928 5351222 A RNA synthesis inhibitor. SGTC_703 3875-0075 71.8 µM -0.207453445682791 0.409262108401576 no 1984 0.417827873351438 2800 2850814 SGTC_1642 st009582 77.7 µM -0.207502372778912 0.409242751861791 no 1985 0.417808769895054 2898 6739311 SGTC_3292 9120825 59.784 µM -0.207616285099042 0.409197686722413 no 1986 0.417764293879855 2850 24824900 SGTC_2700 st077718 96.8 µM -0.210451317717499 0.408076500402274 no 1987 0.416657721795999 2831 904970 SGTC_3139 9095020 49.47 µM -0.211723373197481 0.407573677384509 no 1988 0.416161426140905 2722 25236292 SGTC_1928 4'-methoxychalcone 40.3 µM -0.211787911706882 0.40754817040331 no 1989 0.416136249834476 3004 641818 SGTC_2703 st077852 53.4 µM -0.213491403371055 0.406875056564747 no 1990 0.415471846841102 2938 6281836 SGTC_1832 st054113 55 µM -0.214136662595917 0.406620161998632 no 1991 0.415220243107298 2827 1251267 SGTC_1214 0358-0031 63.7 µM -0.214528737495098 0.406465301293122 no 1992 0.415067379648251 3064 4301366 SGTC_1348 1493-0373 93.8 µM -0.215226277046077 0.406189825146425 no 1993 0.414795452418753 2864 3010129 SGTC_1144 3486-0183 12.5 µM -0.215736714185162 0.405988269924169 no 1994 0.414596490625415 2798 6744069 SGTC_3345 9148410 3.559 µM -0.21575574047135 0.405980757536543 no 1995 0.414589074848427 2917 4903596 SGTC_3263 9137018 49.47 µM -0.219410786342446 0.404538235123335 no 1996 0.413165034223099 2845 43844957 SGTC_1870 st057514 26.5 µM -0.219437690115048 0.404527621901835 no 1997 0.41315455646755 2745 5393161 SGTC_842 0271-0008 11.1 µM -0.220004795713522 0.404303921779638 no 1998 0.412933709883899 2896 1221709 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.221272813725355 0.403803853461399 no 1999 0.412440008424255 2812 17037758 SGTC_2708 st078559 56 µM -0.22190800652142 0.403553411493141 no 2000 0.412192748807517 2843 17250902 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.222663272138502 0.403255679030559 no 2001 0.411898794161686 2795 2724278 An inhibitor of dopamine biosynthesis. SGTC_284 0988-0104 32.6 µM -0.225440422828265 0.402161384790201 no 2002 0.410818334010022 2894 4666532 SGTC_1999 st074831 12.5 µM -0.225508698548375 0.402134491392835 no 2003 0.410791779587893 2829 17112523 SGTC_1430 4049-0248 69.1 µM -0.226871406827536 0.401597825823722 no 2004 0.41026186819799 2915 22774488 SGTC_2255 7941087 197.44 µM -0.228999704923017 0.400760025056718 no 2005 0.409434572734918 2962 935561 SGTC_959 1222-0044 107 µM -0.229263991637771 0.400656020830189 no 2006 0.40933186932525 2923 6083612 SGTC_2830 7992007 71.43 µM -0.229698822469474 0.400484918043939 no 2007 0.409162904989083 2696 1952075 SGTC_3004 9076122 71.4286 µM -0.230125648331239 0.400316983725992 no 2008 0.40899706759513 2964 44782551 SGTC_2475 5812728 15.03 µM -0.230136089745077 0.400312875790274 no 2009 0.408993010929525 2780 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_534 k292-0788 63.4 µM -0.230885839394553 0.400017932774252 no 2010 0.408701746035361 2897 4146317 SGTC_1096 rimcazole 32.2 µM -0.231934058757531 0.399605670783218 no 2011 0.408294615320752 2797 18528119 A dopamine reuptake inhibitor. SGTC_2048 5246248 200 µM -0.232267591472191 0.399474516667189 no 2012 0.408165091213348 2903 677046 SGTC_2938 9059746 27.26 µM -0.232343740617696 0.399444574346414 no 2013 0.408135520857632 2942 6471769 SGTC_1123 mangostin 811.285 nM -0.233036464311562 0.399172218236722 no 2014 0.407866545352753 2899 5281650 An antioxidant. SGTC_3082 9117008 49.47 µM -0.23445833448345 0.398613339653576 no 2015 0.407314588007425 2856 41448529 SGTC_1309 pyrazolanthrone 13.4 µM -0.235726859446518 0.3981149101463 no 2016 0.406822313158309 2923 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_280 3448-3607 3.04 µM -0.236055328845067 0.3979858748332 no 2017 0.406694868421113 2917 626179 SGTC_986 1493-0483 84 µM -0.236878557042609 0.397662528437433 no 2018 0.406375502807683 2885 40079 SGTC_2846 9008642 19.48 µM -0.236885275451853 0.397659889879133 no 2019 0.40637289670377 2964 2992898 SGTC_2779 methotrexate 400 µM -0.24011949351314 0.396390243158821 no 2020 0.405118811295375 2904 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3083 9117465 49.47 µM -0.240339299946831 0.396303994140931 no 2021 0.405033615362578 2931 16420915 SGTC_1839 st053978 48 µM -0.241008659073396 0.396041378110525 no 2022 0.404774202671842 2901 3788398 SGTC_128 0906-2981 13.371 µM -0.24131268980815 0.395922110414419 no 2023 0.404656388210538 2993 6740226 SGTC_3277 9138724 49.47 µM -0.242529979432992 0.395444679657458 no 2024 0.404184764950076 2900 15943418 SGTC_1407 3909-7909 12.3 µM -0.242715147785781 0.395372068873007 no 2025 0.404113036028352 2836 4411780 SGTC_2313 7726885 200 µM -0.242855120974404 0.395317183054051 no 2026 0.404058816559399 2946 726423 SGTC_1548 st061468 90.8 µM -0.243431907712261 0.395091037285742 no 2027 0.403835414152045 2959 390799 SGTC_3310 9130229 44.1445 µM -0.244673053614571 0.394604530380243 no 2028 0.403354797031276 3003 7761258 SGTC_2007 4011539 71.82 µM -0.244905197173847 0.394513552493996 no 2029 0.403264918727323 2825 45595301 SGTC_2208 7283366 200 µM -0.244953100744448 0.394494779630317 no 2030 0.403246372685877 2929 898663 SGTC_193 1273-0060 1.558 µM -0.245708563098966 0.394198754968303 no 2031 0.402953921493873 2825 2847393 YHR072W ERG7 SGTC_9 0092-0002 10.449 µM -0.245763323353753 0.394177299772032 no 2032 0.402932725058113 2887 759368 SGTC_1204 4049-0315 18.3 µM -0.245770624364311 0.39417443924323 no 2033 0.402929899026318 3083 588402 SGTC_2087 5276107 200 µM -0.247876574458962 0.393349568930587 no 2034 0.402114952626231 2816 144405 SGTC_1883 5-benzylidenerhodanine 20 µM -0.248378389985056 0.393153085473599 no 2035 0.401920826048761 2964 1273210 SGTC_3092 9117248 49.47 µM -0.248909955822018 0.392944983108062 no 2036 0.401715216998044 2837 17141857 SGTC_265 mycophenolic acid 32.932 µM -0.250198500528761 0.392440658646631 no 2037 0.401216922396368 3078 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2804 7954240 19.48 µM -0.250254960969433 0.392418564676647 no 2038 0.401195092182093 3010 828705 SGTC_2417 cerulenin 830 nM -0.250278834698225 0.392409222568224 no 2039 0.401185861588596 2899 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3029 9088683 49.47 µM -0.252409263051908 0.39157580778361 no 2040 0.400362370508652 3003 25236615 SGTC_2877 9040724 71.43 µM -0.255215488170982 0.390478783712955 no 2041 0.399278334625486 3062 6463895 SGTC_2713 st079149 53.4 µM -0.255446640793041 0.390388459056184 no 2042 0.399189075587421 2943 3103253 SGTC_2854 9024559 71.43 µM -0.256309978227799 0.390051155690673 no 2043 0.398855746517554 2948 3163529 SGTC_1821 st053465 65.6 µM -0.25636266648031 0.390030573224464 no 2044 0.39883540630522 2932 675086 SGTC_3136 9095672 49.47 µM -0.256641089651641 0.389921813388095 no 2045 0.398727926065683 2762 17217380 SGTC_2220 6782180 200 µM -0.256896642309779 0.38982199499492 no 2046 0.398629281334112 2910 833803 SGTC_1559 coumarin 343 70.1 µM -0.257133934110771 0.389729315764263 no 2047 0.398537691192 3018 108770 A hepatotoxic, DNA x-linker. SGTC_827 3253-0474 693 µM -0.257334641547027 0.389650930209546 no 2048 0.3984602262841 2984 5402065 SGTC_2 0422-0095 29 µM -0.258002637027352 0.38939007936502 no 2049 0.398202436028078 2873 6790840 SGTC_1876 myriocin 605 nM -0.258922710599663 0.389030874157602 no 2050 0.397847437517557 3022 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1448 4255-0083 152 µM -0.261091659839435 0.388184472138718 no 2051 0.397010911582827 3011 5399660 SGTC_2299 7976368 114.88 µM -0.261349154934415 0.388084023461053 no 2052 0.396911631588386 3011 2979718 SGTC_2517 totarol 10 µM -0.261915362267918 0.387863172670244 no 2053 0.396693347786482 2940 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2123 5259487 200 µM -0.262002904979233 0.387829029620696 no 2054 0.396659601277439 2983 2173474 SGTC_2862 9027634 71.43 µM -0.262313709256971 0.387707818016677 no 2055 0.396539796764439 2829 5012562 SGTC_1686 st019653 115.5 µM -0.263163071544589 0.387376628209961 no 2056 0.396212446243601 3001 97252 SGTC_1452 4194-0072 190 µM -0.265238825484348 0.386567579751658 no 2057 0.395412743618187 3035 1343545 SGTC_3152 9099253 49.47 µM -0.266195894996206 0.386194716911588 no 2058 0.395044172164301 2964 25236131 SGTC_1261 0712-0010 12.7 µM -0.266486871270836 0.386081376848218 no 2059 0.394932134586545 3050 2840123 SGTC_2130 NSC 7 2.4545 µM -0.266948429862104 0.385901612100873 no 2060 0.394754433773559 3001 21448 SGTC_256 clotrimazole 625 nM -0.267012944843839 0.385876487188675 no 2061 0.394729597143183 2939 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.268028510727505 0.385481045243887 no 2062 0.394338686494463 2998 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2470 5664817 21.68 µM -0.268835599103118 0.385166865311132 no 2063 0.394028098663406 2852 2859561 SGTC_1394 3474-0001 65.7 µM -0.268901563148427 0.385141190436613 no 2064 0.394002717021954 2921 5017666 YIL048W NEO1 SGTC_1481 3346-2004 36 µM -0.269532728761102 0.384895550292257 no 2065 0.393759879932602 2906 2770522 SGTC_647 0140-0236 81 µM -0.270648435396167 0.38446144713353 no 2066 0.393330719767694 2922 990837 SGTC_2278 7948257 134.34 µM -0.270744443999333 0.384424098521231 no 2067 0.393293795795651 3041 1247028 SGTC_482 fipronil 114 µM -0.271458800121942 0.384146238284052 no 2068 0.393019091560182 2891 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_608 k048-0125 159 µM -0.273208247879692 0.383466014291565 no 2069 0.392346570098197 3006 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_963 1269-2853 151 µM -0.275029082299693 0.382758414895157 no 2070 0.391646947555221 2907 3668223 SGTC_1247 0448-0043 5.84 µM -0.275694984821807 0.382499734269824 no 2071 0.391391173969697 3011 3089013 YGL099W LSG1 SGTC_57 miconazole 162.5 nM -0.275717557468383 0.382490966477438 no 2072 0.391382504623852 2837 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.276842128485892 0.38205423071813 no 2073 0.390950665523294 2981 5379071 SGTC_2083 5306046 65.942 µM -0.277951700362435 0.381623467031773 no 2074 0.390524717887315 2914 539837 SGTC_1011 4112-3381 17.4 µM -0.278202730184837 0.381526031257649 no 2075 0.390428369588156 3057 2877139 SGTC_1581 himbacine 57.9 µM -0.278312528880971 0.38148341588818 no 2076 0.390386229627859 2889 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2385 9074692 200 µM -0.279569523831814 0.380995650071437 no 2077 0.389903895758277 2925 17046906 SGTC_928 2764-0428 58.7 µM -0.280082242479915 0.380796748350901 no 2078 0.389707204074708 3013 662578 SGTC_2723 salbutamol 83.58 µM -0.280658193285513 0.38057335420421 no 2079 0.389486288641168 3002 9884233 β2-adrenoceptor agonist SGTC_1023 4482-3888 16 µM -0.281369002703392 0.380297707321849 no 2080 0.38921369519633 3100 3303168 SGTC_1172 0370-0043 85 µM -0.281863195769156 0.380106098542488 no 2081 0.389024205641007 3053 376585 SGTC_1666 st014829 29 µM -0.282819077930257 0.379735566969176 no 2082 0.388657764534781 2856 3858230 SGTC_517 1365-0151 113 µM -0.283579014467329 0.379441069159225 no 2083 0.388366510598266 3074 768657 SGTC_676 falcarinol 140 µM -0.284977635788438 0.378899245076156 no 2084 0.38783063793272 3097 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2166 5933061 31.504 µM -0.285426773399023 0.378725300160223 no 2085 0.387658599029374 3390 2877375 SGTC_2446 5162541 200 µM -0.285886899533055 0.378547125010064 no 2086 0.387482373921307 2877 1549321 SGTC_3318 9139014 38.6185 µM -0.286043610110258 0.378486447691999 no 2087 0.38742236015051 2888 16643984 SGTC_2528 xanthyletin 44.79 µM -0.286697674019838 0.378233230753974 no 2088 0.387171909362578 2896 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.287043812737007 0.37809924636749 no 2089 0.387039386700958 2870 5355888 SGTC_822 1487-0950 154 µM -0.287451937741527 0.377941286980916 no 2090 0.386883148886107 3059 1958375 SGTC_2979 9012552 45.46 µM -0.28821542954684 0.377645842381484 no 2091 0.386590919307533 3024 17100905 SGTC_2832 7992762 51.95 µM -0.288473249349671 0.377546091300237 no 2092 0.38649225224898 2871 2985177 SGTC_2722 naftopidil 47.16 µM -0.28927596456443 0.377235571245077 no 2093 0.386185101958803 3003 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2845 9003024 42.97 µM -0.289845524359801 0.377015292484395 no 2094 0.385967209307633 3140 2990173 SGTC_2179 6298986 200 µM -0.289872755805526 0.377004761652487 no 2095 0.385956792457453 3063 738374 SGTC_508 roscovitine 141 µM -0.292299582179974 0.376066637656631 no 2096 0.385028789121732 2913 160355 A CDKinase inhibitor. SGTC_2387 9077560 195.08 µM -0.29248382912646 0.375995444221305 no 2097 0.384958361047245 2927 5303272 SGTC_888 0916-0002 6.97 µM -0.293724471355395 0.375516167264502 no 2098 0.384484226641555 3081 2802138 YIL048W NEO1 SGTC_2651 TUB2.036 5 µM -0.294458581495449 0.37523266093039 no 2099 0.384203754162783 3056 15992207 YFL037W TUB2 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.295003320307589 0.375022331539381 no 2100 0.383995671644238 3121 551469 SGTC_557 1315-0110 16.2 µM -0.295720332339674 0.374745542299009 no 2101 0.383721834171658 2912 6833801 SGTC_1113 artemisinin 1.17947 µM -0.295756743295339 0.374731488242734 no 2102 0.383707929838431 3027 2240 An anti-malaria and mitochondrial poison. SGTC_962 1254-0300 21.5 µM -0.297735182761079 0.373968092317536 no 2103 0.382952644281307 2897 7340576 SGTC_790 1575-0012 79.1 µM -0.299913387647863 0.373128186832207 no 2104 0.382121611135942 3098 378741 YLR208W SEC13 SGTC_2815 7968870 71.43 µM -0.301966244943926 0.372337166208608 no 2105 0.381338897560341 2931 2977326 YHR190W ERG9 SGTC_2423 st077119 87.2 µM -0.302157033310406 0.372263677655305 no 2106 0.381266178346916 2932 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_350 k064-0020 19.8 µM -0.302538863774221 0.372116616788289 no 2107 0.381120655802598 3135 2790705 SGTC_2223 6903751 107.57 µM -0.302785451930512 0.372021654004025 no 2108 0.381026685496936 3031 5598863 SGTC_269 exalamide 29 µM -0.302831851731099 0.372003785993684 no 2109 0.381009004152653 2946 3316 A derivative of salicylamide. SGTC_3039 9090270 49.47 µM -0.303691305793266 0.371672870350586 no 2110 0.380681541168727 3068 17173750 SGTC_2679 rapamycin 1 nM -0.303968284288159 0.371566245493093 no 2111 0.380576027019573 3019 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2467 5474540 200 µM -0.304426619444779 0.371389827734502 no 2112 0.380401445094959 2932 5413519 SGTC_1046 2001-0062 216 µM -0.305744013180483 0.370882900323634 no 2113 0.37989977962791 2925 739778 SGTC_945 3381-0768 11.3 µM -0.305868090684969 0.370835167366003 no 2114 0.379852541129612 3098 1126236 YIL048W NEO1 SGTC_315 k915-0449 187 µM -0.307699671341179 0.370130784839586 no 2115 0.379155434916723 2987 20970215 YNL149C PGA2 SGTC_173 1273-0061 2.693 µM -0.307779398460133 0.37010013354942 no 2116 0.379125099392368 3049 2847414 YPL266W DIM1 SGTC_3122 9126309 49.47 µM -0.308114701656847 0.36997123443022 no 2117 0.378997527386505 3024 17591206 SGTC_755 1995-0008 37.3 µM -0.308253626607983 0.36991783240661 no 2118 0.378944674803046 3042 689533 SGTC_1534 6-azauridine 81.6 µM -0.30953518989151 0.369425324605382 no 2119 0.378457223958263 2939 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3281 9140613 49.47 µM -0.309946640665126 0.369267248485783 no 2120 0.378300766971164 2983 16013766 SGTC_49 0717-0965 32.132 µM -0.311928192252382 0.368506262082733 no 2121 0.377547548193289 3231 5889349 YGL099W LSG1 SGTC_1251 0490-5699 265 µM -0.312571757425617 0.36825922087108 no 2122 0.377303018993324 3134 3883818 SGTC_358 0075-0058 9.45 µM -0.312736031695175 0.368196170687621 no 2123 0.377240609172798 3005 1069125 SGTC_1462 k081-0014 26.5 µM -0.313351098256915 0.367960133245671 no 2124 0.377006966289888 2965 3270634 SGTC_410 α-linolenic acid 100 µM -0.313853521577195 0.367767360666763 no 2125 0.376816146154514 3075 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1620 st003704 16.5 µM -0.314652231910329 0.367460975610014 no 2126 0.376512858305635 3042 2834414 SGTC_1653 st012112 65 µM -0.315109067618045 0.367285771469456 no 2127 0.376339422007941 3127 720429 SGTC_883 0850-0245 24.6 µM -0.315675351380408 0.367068630520101 no 2128 0.376124468743166 3162 6823229 YPR165W RHO1 SGTC_3216 9129716 49.47 µM -0.317319052904583 0.366438595821031 no 2129 0.375500760855195 2978 8056934 SGTC_2303 7774051 200 µM -0.318448346504312 0.366005943296126 no 2130 0.375072435115997 3155 2953184 SGTC_641 4092-0595 30 µM -0.318505805475337 0.365983934288367 no 2131 0.375050645821122 3043 786260 SGTC_2761 levamisole 97.89 µM -0.319387833083908 0.365646138989496 no 2132 0.374716217938539 3119 26879 An alkaline phosphatase inhibitor. SGTC_2892 9047358 58.44 µM -0.31975385201675 0.365505993131917 no 2133 0.374577466549839 3009 6466771 SGTC_1312 1218-2183 165 µM -0.321687775425559 0.364765807044573 no 2134 0.37384461989376 2989 6744073 SGTC_1391 3442-0225 151 µM -0.323049491941501 0.364244928374907 no 2135 0.373328880309437 2964 5227075 SGTC_2529 gangaleoidin 93.61 µM -0.324618938637655 0.363644900482141 no 2136 0.372734745949583 2948 4565183 SGTC_1552 6-methylflavone 10.6 µM -0.325302070522347 0.363383831125574 no 2137 0.372476231983019 3038 689013 SGTC_505 gw-5074 63.9 µM -0.325362581499628 0.363360708981935 no 2138 0.372453335903481 3075 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2395 5646831 180.19 µM -0.325412125104795 0.363341778004832 no 2139 0.372434589982217 3151 6808628 SGTC_1218 1348-1416 30.7 µM -0.327884646747775 0.362397434098294 no 2140 0.371499441358807 2954 6787668 SGTC_253 dyclonine 31.25 µM -0.32897432947412 0.36198151080439 no 2141 0.371087545596006 2991 3180 An oral anasthetic. SGTC_2602 kawain 100 µM -0.330864678857258 0.361260366123724 no 2142 0.370373351445917 3028 5369129 SGTC_2404 5161160 200 µM -0.332360452269445 0.360690096284076 no 2143 0.36980854865837 2917 2831543 SGTC_1489 4065-0444 182 µM -0.333834007032779 0.360128600147171 no 2144 0.369252410098765 3120 2877968 SGTC_3167 9103034 49.47 µM -0.335039511006485 0.35966946865714 no 2145 0.368797640718428 3022 5127859 SGTC_839 0122-0028 230 µM -0.335953865069937 0.359321360286398 no 2146 0.368452828388971 3011 759448 SGTC_402 epigallocatechin gallate 10 µM -0.336493661378218 0.359115906479372 no 2147 0.368249315343556 3005 65064 An antioxidant. SGTC_281 1672-3440 14.9 µM -0.339199410366296 0.358086676628047 no 2148 0.367229756711609 3096 6833000 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.340083504498549 0.357750602332969 no 2149 0.366896821863471 3011 688669 SGTC_58 0957-0393 9 µM -0.340649372879327 0.357535554331432 no 2150 0.366683777950835 3129 6997992 SGTC_3333 9141820 12.094 µM -0.341945595795192 0.357043118897894 no 2151 0.366195917558503 3013 1939433 SGTC_1597 7-benzyloxygramine 47.5 µM -0.342204490378006 0.356944793272546 no 2152 0.366098503088773 3011 260807 SGTC_1154 4088-0362 150 µM -0.343118708903991 0.356597658094657 no 2153 0.365754578442959 2989 6618304 SGTC_2921 7974240 10.71 µM -0.343269051086015 0.356540583477497 no 2154 0.36569803075279 3137 2979074 YDR527W RBA50 SGTC_3019 9081971 49.47 µM -0.343446868644825 0.356473082490603 no 2155 0.365631152610241 3173 16451803 SGTC_469 w7 172 µM -0.343884322192258 0.356307040716326 no 2156 0.365466641359424 3036 45115570 A P450 inhibitor. SGTC_1339 1486-1321 22.7 µM -0.344311830155767 0.356144800247065 no 2157 0.365305894209457 3028 3469382 SGTC_1400 3771-8998 51.5 µM -0.344608619182588 0.356032183292688 no 2158 0.365194312562866 3006 670767 SGTC_76 0433-0009 400.328 µM -0.3455212090383 0.35568597868988 no 2159 0.364851284214732 3108 2841569 SGTC_1435 4092-0789 56.7 µM -0.345571901887532 0.355666751086186 no 2160 0.364832232728507 3113 2248285 SGTC_1205 4161-2785 76 µM -0.346006904998317 0.355501771172481 no 2161 0.364668762728651 3116 3498106 SGTC_3063 1327-0034 4 µM -0.349747508074597 0.354084224723784 no 2162 0.363264098167597 3108 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1119 parthenolide 318.541 nM -0.350286884918882 0.353879987560067 no 2163 0.363061703433784 3214 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1843 st055809 45.5 µM -0.352083883615316 0.353199850576799 no 2164 0.362387677273828 3167 16413835 SGTC_427 1354-0053 47.3 µM -0.353326227117308 0.352729916083768 no 2165 0.361921942750969 3221 6813657 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.355345788093848 0.351966467401613 no 2166 0.361165278413571 3261 6710655 SGTC_1508 1080-0625 72.9 µM -0.355636756056631 0.351856522721142 no 2167 0.361056306779658 2986 767111 SGTC_1175 0741-0056 27.6 µM -0.357151608475969 0.35128432334761 no 2168 0.360489155385623 3223 765927 SGTC_1146 3579-1023 7 µM -0.358494654371141 0.350777301500503 no 2169 0.359986583807341 3157 X1146 SGTC_1826 st055655 41.6 µM -0.358636551740825 0.350723748416916 no 2170 0.359933499525824 3108 676168 SGTC_893 0958-0369 48.9 µM -0.359546798732567 0.350380285261446 no 2171 0.359593037360864 3156 6819948 SGTC_3163 9099914 49.47 µM -0.359735895893099 0.350308948635136 no 2172 0.359522322802016 3125 16268368 SGTC_3003 9075612 71.4286 µM -0.359840172226107 0.350269612800158 no 2173 0.359483329800752 3101 6501993 SGTC_1297 1068-0111 14.1 µM -0.359884413174732 0.350252924410702 no 2174 0.359466786820936 3024 767057 SGTC_990 3985-0011 41.3 µM -0.360812935185913 0.349902737897521 no 2175 0.359119646202353 3070 5399565 YGL099W LSG1 SGTC_1369 1866-0067 208 µM -0.361124976372194 0.349785082072121 no 2176 0.359003011440784 3192 3531355 SGTC_1331 1472-0049 76.2 µM -0.361432156360785 0.349669273260498 no 2177 0.358888206534577 2991 24051409 SGTC_3110 9122132 49.47 µM -0.36214276800778 0.349401421767029 no 2178 0.358622672655213 3211 918317 SGTC_2178 5812956 200 µM -0.363418611352138 0.348920705199464 no 2179 0.358146100481016 2990 5403383 SGTC_523 1934-0222 13.7 µM -0.364446790082896 0.348533480871876 no 2180 0.357762200436961 3046 1361595 SGTC_1075 aripiprazole 15.2 µM -0.36449902111653 0.348513814251678 no 2181 0.357742702316983 3026 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1404 3909-7820 48.3 µM -0.365216055889873 0.348243869383327 no 2182 0.357475067005882 3151 23741373 SGTC_1770 st043884 66.3 µM -0.365578559650609 0.348107425426314 no 2183 0.357339788086781 3026 670149 SGTC_2797 7859098 81.82 µM -0.366807252584727 0.347645100083285 no 2184 0.356881398697316 3048 972681 SGTC_3057 9095946 49.47 µM -0.366949155006731 0.347591720452177 no 2185 0.356828472348069 3014 24540043 SGTC_2822 7994718 71.43 µM -0.367147854905807 0.347516980313431 no 2186 0.356754366473766 3066 1018011 SGTC_2572 astragaloside iv 100 µM -0.368839696495923 0.346880841507418 no 2187 0.356123607025309 3210 45006101 An anti-inflammatory agent. SGTC_2596 sinensetin 100 µM -0.369865339312725 0.346495405839842 no 2188 0.355741414061836 3086 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2594 a-mangostin 100 µM -0.370069186976558 0.346418818981399 no 2189 0.355665470037549 3188 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_834 0312-0008 75.7 µM -0.37320948067353 0.345239785783028 no 2190 0.35449627028216 3062 6385573 YIL048W NEO1 SGTC_1674 st016616 23.6 µM -0.373667314057511 0.345068015847463 no 2191 0.354325923088763 3024 625830 SGTC_3100 9120536 49.47 µM -0.373842352365519 0.345002353404864 no 2192 0.354260803853319 3124 16421196 SGTC_1417 3966-0327 90.4 µM -0.375290282944169 0.344459367686235 no 2193 0.353722296012264 3115 651118 SGTC_2081 5214970 32.255 µM -0.375433535003981 0.344405664399676 no 2194 0.353669034236602 3173 2063512 SGTC_272 doxorubicin 8.13 µM -0.375632951513275 0.344330911032644 no 2195 0.353594895029287 3092 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3273 9137859 49.47 µM -0.375658715291358 0.344321253654107 no 2196 0.353585316959138 3140 2377234 SGTC_56 0957-0365 83.25 µM -0.377328871781648 0.343695423576106 no 2197 0.352964609316337 3191 6752360 SGTC_187 1488-2104 32.728 µM -0.377556385929427 0.343610204063159 no 2198 0.352880084732891 3140 2852859 SGTC_961 1252-1571 372 µM -0.378822113420339 0.343136248287294 no 2199 0.352409982502372 3243 6813498 SGTC_138 0850-0259 40.9225 µM -0.379007856375363 0.343066716970424 no 2200 0.352341014894836 3158 6813004 SGTC_395 anisomycin 6.25 µM -0.379637550398196 0.342831035848703 no 2201 0.352107241413191 3128 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1742 st038235 28.8875 µM -0.379775436933154 0.342779436000366 no 2202 0.352056058584843 3176 564103 YBR002C RER2 SGTC_2922 7999257 32.47 µM -0.380258699838323 0.342598612692293 no 2203 0.351876694847713 3112 2988377 SGTC_1199 1638-0010 4.46 µM -0.380381548025749 0.342552652123264 no 2204 0.351831104814971 3067 3111136 SGTC_1216 1165-0504 9.65 µM -0.381058888154935 0.342299284171419 no 2205 0.351579776261423 3204 6304004 SGTC_2483 5729050 27.16 µM -0.382718222897002 0.341678888334889 no 2206 0.350964350712729 3249 2865180 SGTC_1502 4534-4282 27.7 µM -0.383073576215658 0.341546083540169 no 2207 0.350832605561266 3124 3278949 SGTC_85 0868-0259 160.055 µM -0.383099778579443 0.341536291810336 no 2208 0.350822891898829 3124 83173 SGTC_1163 k060-0048 49.9 µM -0.383101624235047 0.341535602099445 no 2209 0.350822207686545 3083 6809982 SGTC_2983 9022671 12.99 µM -0.383416575101509 0.341417914521797 no 2210 0.350705457751323 3265 6405161 SGTC_308 4092-1169 104 µM -0.384720238285425 0.34093093927482 no 2211 0.35022234959704 3079 2268590 YDL196W YDL196W SGTC_3246 9135460 32.98 µM -0.384801558841916 0.340900571257977 no 2212 0.350192222053413 3162 41446951 SGTC_1853 st056710 91.2 µM -0.385136707782083 0.340775425486103 no 2213 0.350068066421272 3228 269167 SGTC_789 1309-1135 70.6 µM -0.385519151451317 0.340632641104857 no 2214 0.349926410075053 3067 3092424 SGTC_1264 0783-0040 158 µM -0.386376411969729 0.340312668030784 no 2215 0.34960895844614 3022 2855798 SGTC_137 0438-0332 85.389 µM -0.387712983004691 0.339814021339435 no 2216 0.349114223434731 3192 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2272 7805186 180 µM -0.389208969615581 0.339256232326918 no 2217 0.348560784383367 3223 2956062 YPR165W RHO1 SGTC_1659 st012954 42.1 µM -0.389244252754794 0.339243081008129 no 2218 0.348547735298627 3195 24207262 SGTC_3099 9120367 49.47 µM -0.389343111451206 0.339206233792804 no 2219 0.348511174441066 3066 24824940 SGTC_2506 ethyl hematommate 54.16 µM -0.389467328590369 0.339159937004274 no 2220 0.348465237279484 3155 3940691 An allergen. SGTC_157 1348-1695 65.819 µM -0.390113462781167 0.338919156455848 no 2221 0.348226324060941 3141 5380510 SGTC_669 0108-0021 26.2 µM -0.390202393072883 0.338886021918304 no 2222 0.348193446095636 3399 17201 SGTC_2936 9038235 15.59 µM -0.39184730388445 0.338273369594715 no 2223 0.347585520439092 3054 4749415 SGTC_952 1185-0122 232 µM -0.39201194525618 0.338212071920034 no 2224 0.347524693871879 3059 678600 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.392660409326372 0.337970683801571 no 2225 0.347285157753789 3217 1377 SGTC_184 1494-0393 24.714 µM -0.39447566038199 0.337295318444081 no 2226 0.346614946805165 3056 3090647 SGTC_718 1130-0073 349 µM -0.394941915350509 0.337121932455628 no 2227 0.346442877630752 3268 6740020 SGTC_1177 0983-0204 23.6 µM -0.395614943630008 0.336871714800238 no 2228 0.346194555633187 3234 766818 SGTC_1373 2887-0003 58.5 µM -0.396121698851268 0.336683361571353 no 2229 0.346007625732752 3145 776948 SGTC_3297 9117502 71.43 µM -0.397135946523629 0.336306504165873 no 2230 0.345633606722254 3193 7453720 SGTC_2341 7987486 176.74 µM -0.397266127825457 0.336258145445329 no 2231 0.345585611318916 3251 1258686 SGTC_2525 harmine 47.85 µM -0.399551861601092 0.335409501154933 no 2232 0.344743309167869 3113 5280953 A monoamine oxidase inhibitor SGTC_3095 9117207 49.47 µM -0.399905812073697 0.335278161802842 no 2233 0.344612945643879 3188 17015229 SGTC_286 k060-0067 22.9 µM -0.401630996411423 0.33463829122363 no 2234 0.343977807266688 3132 5985051 SGTC_824 1304-0008 100 µM -0.401848914424517 0.334557499573047 no 2235 0.343897610525973 3126 768245 SGTC_1526 st051518 75 µM -0.402234658115449 0.334414506454088 no 2236 0.34375566891277 3119 673993 SGTC_590 k048-0076 22.4 µM -0.403232361950586 0.334044774440384 no 2237 0.343388647289289 3229 6832814 SGTC_2927 9011802 47.9 µM -0.405118993136238 0.333346061444137 no 2238 0.342695023009916 3212 43912568 SGTC_2734 clemastine 41.6 µM -0.405324632791462 0.333269937776021 no 2239 0.342619451111723 3146 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2390 9097792 176.6 µM -0.406764060883449 0.332737282845799 no 2240 0.342090642515638 3135 4497149 SGTC_2702 st077768 96.8 µM -0.406982695623704 0.332656407379135 no 2241 0.342010348830512 3191 6484119 SGTC_2080 5212524 12.4 µM -0.407163086720229 0.332589684532577 no 2242 0.341944105515874 3232 260183 SGTC_759 3486-0358 89.3 µM -0.407763889916475 0.332367498407695 no 2243 0.34172351334247 3292 875103 SGTC_1446 4239-0190 62 µM -0.408232015643793 0.332194419238709 no 2244 0.341551672759746 3122 1340085 SGTC_407 eburnamonine 100 µM -0.408921034079708 0.331939734968642 no 2245 0.34129880615641 3078 3195 SGTC_294 k038-0071 157 µM -0.408939802294524 0.331932798694021 no 2246 0.341291919303897 3169 24152826 SGTC_1986 st071812 45 µM -0.409209880264321 0.331832990840246 no 2247 0.341192822117863 3201 11838594 SGTC_882 0843-0131 351 µM -0.411952549406319 0.330820108966005 no 2248 0.340187101492355 3268 5425421 SGTC_879 0831-1030 162 µM -0.412725516702114 0.330534871328827 no 2249 0.339903863800243 3150 1549252 SGTC_1540 guanosine 70.6 µM -0.413117874353059 0.330390122548831 no 2250 0.339760127108409 3179 6802 Guanosine is a purine nucleoside SGTC_1815 st051655 58.2 µM -0.413317093229099 0.33031663633274 no 2251 0.339687153983541 3223 5984156 SGTC_2075 5212009 200 µM -0.413599753303551 0.330212382244894 no 2252 0.33958362697244 3259 780898 SGTC_1148 3909-7663 27.7 µM -0.413878879524443 0.330109444489388 no 2253 0.339481406146096 3246 4084526 SGTC_1279 0874-0590 65.2 µM -0.414289541095039 0.329958021758235 no 2254 0.339331036278886 3178 3523074 SGTC_165 k038-0023 64.381 µM -0.415176505677939 0.329631067492114 no 2255 0.339006348268983 3137 46368543 SGTC_1438 4092-1045 4 µM -0.416248849445334 0.329235952292346 no 2256 0.338613958803568 3142 1351342 SGTC_2224 6650123 117.647 µM -0.418238526424791 0.328503342286057 no 2257 0.337886365119822 3187 2908370 SGTC_376 3970-0862 59.1 µM -0.418838240902043 0.328282653200738 no 2258 0.337667177530406 3242 3135186 SGTC_2168 5727979 200 µM -0.419999926577346 0.327855334669355 no 2259 0.337242753666805 3170 695210 SGTC_1005 4092-0690 4.4 µM -0.420400583027362 0.327708008017692 no 2260 0.337096421132919 3157 1529343 SGTC_3337 9144342 33.5465 µM -0.421147826980275 0.327433308238497 no 2261 0.336823569633088 3229 17682949 SGTC_1736 st036774 51 µM -0.42135044052991 0.32735884009077 no 2262 0.336749601340904 3359 1272247 SGTC_2196 6573537 42.6665 µM -0.423275403392909 0.326651686417276 no 2263 0.336047168924273 3265 2903087 SGTC_3034 9090421 49.47 µM -0.42327969938012 0.32665010894003 no 2264 0.3360456019275 3210 17173761 SGTC_2057 5236571 38.335 µM -0.424039496133629 0.326371161977619 no 2265 0.335768504633167 3314 54684039 YBR257W POP4 SGTC_273 hydroxyurea 18.1 mM -0.425619911303479 0.325791249495562 no 2266 0.335192414516988 3134 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2690 usnic acid 100 µM -0.426188705974157 0.325582640814581 no 2267 0.334985173235663 3378 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2848 9016370 25.97 µM -0.426756385370476 0.325374495621012 no 2268 0.334778388390791 3306 7894410 SGTC_285 1486-1325 46 µM -0.429774054411658 0.324268953276284 no 2269 0.333680004070452 3271 22310230 SGTC_2059 5238311 157 µM -0.430082201380758 0.324156148580681 no 2270 0.333567923363726 3095 703021 SGTC_2314 7727897 200 µM -0.432708815590272 0.32319526859474 no 2271 0.332613162300648 3148 900724 SGTC_559 1550-0661 158 µM -0.43281661365854 0.323155858545546 no 2272 0.332574001376309 3236 5830875 SGTC_396 dithiazanine 1.25 µM -0.435000336967963 0.322357935906053 no 2273 0.331781091423946 3170 10578 An antihelmenthic. SGTC_1845 st056753 3.01 µM -0.435154474663107 0.322301645543991 no 2274 0.331725152434721 3124 5375839 SGTC_1080 nisoldipine 24.4 µM -0.435676323159752 0.322111099181043 no 2275 0.331535793283614 3110 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2618 avocadyne 43.43 µM -0.436559891169678 0.321788582126152 no 2276 0.33121527792199 3168 3015189 SGTC_2084 5306078 60.6385 µM -0.436837340972451 0.321687336002523 no 2277 0.331114658163033 3164 679340 SGTC_64 000l-0018 272.079 µM -0.437311924433201 0.321514183171925 no 2278 0.330942574316737 3141 6811119 SGTC_689 0833-0039 98 µM -0.438141867586493 0.321211469775141 no 2279 0.330641722983181 3224 5374726 SGTC_899 1083-0020 478 µM -0.439166737219129 0.320837822780363 no 2280 0.330270362468391 3326 767123 SGTC_542 3381-0244 89.3 µM -0.441122410404016 0.320125326984645 no 2281 0.329562190137971 3320 1112843 SGTC_3185 9108267 49.47 µM -0.442124162519683 0.319760622651546 no 2282 0.329199680257263 3271 4910486 SGTC_3240 9133527 49.47 µM -0.442252608924061 0.319713872217646 no 2283 0.329153210212201 3197 17617455 SGTC_3341 9147222 25.867 µM -0.442961600434216 0.319455873257791 no 2284 0.328896754887313 3306 1939759 SGTC_479 n-linoleoylglycine 10 µM -0.443076405425675 0.319414104431913 no 2285 0.328855235374275 3206 6433346 An anti-infammatory. SGTC_782 0083-0095 30.5 µM -0.443633626509647 0.319211406515198 no 2286 0.328653744981514 3156 3591729 An indicator and reagent. SGTC_133 0724-0033 378.92 µM -0.444371576203632 0.318943048895157 no 2287 0.328386980027 3093 280309 SGTC_3 0833-0587 95.581 µM -0.444397896521452 0.318933479184287 no 2288 0.328377466984504 3236 5382644 SGTC_2981 9013952 38.96 µM -0.445289163590806 0.318609497836895 no 2289 0.328055398991765 3201 2996344 SGTC_135 0933-0004 26.348 µM -0.445297804854967 0.31860635735959 no 2290 0.328052277012408 3300 21230617 YGL099W LSG1 SGTC_1402 3909-7673 35.9 µM -0.445356529883402 0.318585015385444 no 2291 0.328031060721228 3199 5328014 SGTC_809 3998-0021 90 µM -0.445450589613842 0.318550833253099 no 2292 0.327997079797115 3301 715485 SGTC_3198 9112019 49.47 µM -0.447192518955403 0.317918080194554 no 2293 0.327368031211999 3229 45595555 SGTC_1008 4106-0037 6 µM -0.447805207687439 0.317695648179316 no 2294 0.327146892343851 3108 2905394 SGTC_467 ro 31-8220 72.8 µM -0.447984758888085 0.317630475932619 no 2295 0.327082098090581 3191 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3048 9093155 49.47 µM -0.448846507832095 0.317317762965696 no 2296 0.326771193173695 3303 25236002 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.448849358324572 0.317316728790195 no 2297 0.326770164962065 3350 165506 SGTC_491 tetrandrine 80.3 µM -0.44927329927602 0.317162936393806 no 2298 0.326617258312384 3250 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1067 clotrimazole 1.36 µM -0.45189470457532 0.316212675292994 no 2299 0.325672419736299 3205 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_774 k060-0086 136 µM -0.454949341783969 0.315106897118892 no 2300 0.324572842005892 3353 5911235 SGTC_3294 9122953 26.2835 µM -0.45665091579017 0.314491644537645 no 2301 0.323960988135461 3210 16459826 SGTC_1273 0849-0096 14.1 µM -0.45808827751687 0.313972326459796 no 2302 0.3234445102339 3240 5286025 SGTC_1970 st070122 35.8 µM -0.459703871677905 0.31338905261612 no 2303 0.322864395067337 3359 102928 SGTC_802 4112-3352 742 µM -0.459940422400063 0.313303690422081 no 2304 0.32277949236551 3339 704594 SGTC_1649 st011737 51.3 µM -0.460383483783528 0.31314383326619 no 2305 0.322620493785348 3255 1761035 SGTC_3200 9114385 49.47 µM -0.460412357652306 0.313133416753027 no 2306 0.322610133131624 3325 17018030 YLR208W SEC13 SGTC_2116 5511452 16.8835 µM -0.460778932706879 0.313001184404596 no 2307 0.322478608969656 3323 870744 SGTC_2307 7538926 6.34 µM -0.46101055656351 0.312917644563883 no 2308 0.322395515656555 3232 96582 SGTC_210 3551-0445 56.827 µM -0.461551265478137 0.312722664319654 no 2309 0.322201574945116 3339 2865180 YOR207C RET1 SGTC_683 panaxydol 45 µM -0.463217842624988 0.312122024509518 no 2310 0.32160411405409 3263 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3322 9139058 2.11 µM -0.463325138730511 0.312083371728967 no 2311 0.321565664635173 3357 4908926 YPR165W RHO1 SGTC_1992 st073643 23.3 µM -0.463660955022793 0.311962409288837 no 2312 0.321445337660991 3209 3161292 SGTC_3288 9119690 36.221 µM -0.463704293626415 0.311946800018587 no 2313 0.321429810288166 3233 17595618 YKL019W RAM2 SGTC_2291 7917025 104.35 µM -0.463858850002028 0.311891136179502 no 2314 0.321374438306855 3156 2964612 SGTC_1051 3253-3903 78 µM -0.464396827731243 0.311697415755557 no 2315 0.321181731230723 3155 5509239 SGTC_2304 7443016 91.4 µM -0.465652028487648 0.311245633110209 no 2316 0.320732297524342 3247 939854 SGTC_1038 k292-0204 154 µM -0.468026199612913 0.31039187852855 no 2317 0.31988292696259 3184 4454212 SGTC_252 miconazole 1.30953 nM -0.469437638361277 0.309884806965561 no 2318 0.319378425142183 3291 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1068 loratadine 26.9 µM -0.470269398317385 0.309586159214951 no 2319 0.31908127897448 3253 3957 A H1 histamine antagonist. SGTC_2518 prenyletin 46.28 µM -0.470381226395087 0.309546016340947 no 2320 0.319041337262611 3292 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3301 9125354 19.7965 µM -0.470485923593955 0.309508435294642 no 2321 0.319003944395928 3283 41905162 SGTC_803 4488-1585 147 µM -0.471292325817953 0.309219044096973 no 2322 0.31871599757398 3320 747204 SGTC_1762 st045503 25.4615 µM -0.472325091584861 0.308848591292673 no 2323 0.31834738159435 3301 4645554 SGTC_3066 9117245 49.47 µM -0.472989070669008 0.308610524804302 no 2324 0.31811048831454 3243 17176980 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.475450779200809 0.307728593564079 no 2325 0.317232854081775 3256 4620898 SGTC_2945 9067681 61.76 µM -0.477579646196717 0.30696680061483 no 2326 0.316474710236411 3353 16456930 SGTC_1523 st012844 44.7 µM -0.479167606572848 0.306399107421107 no 2327 0.315909698551609 3360 4274103 SGTC_1476 4112-3294 3.34 µM -0.479501635742316 0.306279751616771 no 2328 0.315790902407834 3362 704369 SGTC_2689 tacrolimus 100 µM -0.480251982081178 0.306011711698089 no 2329 0.315524114108379 3298 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3088 9117578 49.47 µM -0.480759373302775 0.305830519435067 no 2330 0.315343763829863 3358 678341 SGTC_313 3474-0040 5.03 µM -0.482526931174546 0.305199685875642 no 2331 0.314715835871965 3209 1043375 YIL048W NEO1 SGTC_1697 st025554 27.742 µM -0.484247077375386 0.304586328411937 no 2332 0.3141052649598 3238 1269519 SGTC_1406 3909-7906 11.9 µM -0.485467122342185 0.304151626145385 no 2333 0.313672514519807 3306 X1406 SGTC_45 0kpi-0036 14.9 µM -0.486277203934078 0.303863146705602 no 2334 0.313385319774772 3369 2795021 SGTC_751 0833-0568 350 µM -0.488425328442715 0.303098766279494 no 2335 0.312624302459643 3322 6954252 SGTC_793 0488-0545 106 µM -0.48998584785897 0.302544016982737 no 2336 0.312071956637317 3227 292548 SGTC_2799 7812892 81.82 µM -0.491778567618351 0.301907285115163 no 2337 0.311437944651996 3382 20205235 SGTC_1291 0993-0025 5.79 µM -0.493030522380585 0.301462977628318 no 2338 0.310995510467422 3399 4353356 SGTC_44 0929-0055 61.211 µM -0.493575414474409 0.301269692277408 no 2339 0.310803033724549 3220 1379590 SGTC_1827 berberine 7.24 µM -0.493803572538377 0.301188776115892 no 2340 0.310722454934919 3219 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2183 6420625 130.508 µM -0.493940137131226 0.301140348224802 no 2341 0.310674228637008 3379 2897619 SGTC_254 nsc-64875 3.808 µM -0.495364277837541 0.300635535387323 no 2342 0.310171502834369 3391 56993 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.496127323415478 0.300365217129095 no 2343 0.309902291348442 3282 88881 An O-methylated flavonoid and antioxidant. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.496168138326488 0.300350761041036 no 2344 0.309887894235997 3357 165521 SGTC_2342 7990637 118.86 µM -0.500231440500868 0.298913171192889 no 2345 0.308456061265537 3378 2033102 YER133W GLC7 SGTC_2727 riluzole 51.77 µM -0.500704845883216 0.298745884614474 no 2346 0.308289430672392 3337 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1691 st019933 84.6 µM -0.501160622028552 0.298584867873637 no 2347 0.308129042582848 3346 6176082 SGTC_853 0419-0306 21 µM -0.501605679217931 0.298427676028602 no 2348 0.30797246185371 3270 762713 SGTC_1605 st000082 49.1 µM -0.501939727382784 0.29830971673033 no 2349 0.307854959457206 3378 1114022 SGTC_1089 terbinafine 2.25 µM -0.502145805608723 0.298236956845937 no 2350 0.307782480677156 3380 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_530 4358-1714 28 µM -0.502631478266143 0.298065512740313 no 2351 0.307611696756043 3353 1564641 SGTC_2310 7668677 200 µM -0.503619671463838 0.29771681589171 no 2352 0.307264333184785 3460 2197143 SGTC_2312 7706453 155.7 µM -0.503857857374401 0.297632796732911 no 2353 0.307180633383847 3288 976098 SGTC_1211 1056-0033 32.3 µM -0.50408233488075 0.297553623067111 no 2354 0.307101759983164 3391 6741922 SGTC_2911 7942208 15.64 µM -0.505033408753627 0.297218284121237 no 2355 0.30676768553916 3352 1243384 SGTC_2364 9055074 200 µM -0.506042786261455 0.296862576970303 no 2356 0.306413306829672 3353 6470630 SGTC_2484 5809818 12.04 µM -0.507781403719536 0.296250341084503 no 2357 0.305803326354195 3306 2870548 SGTC_2439 5492030 7.2 µM -0.508299752174612 0.296067922246469 no 2358 0.305621571912724 3356 5722370 SGTC_1511 0906-3109 28.5 µM -0.509682896997578 0.295581414010269 no 2359 0.305136818484523 3370 2882180 SGTC_422 cantharidin 155 µM -0.511286789285625 0.295017720587048 no 2360 0.304575127059064 3302 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_881 0833-0569 170 µM -0.511933622356454 0.294790529109396 no 2361 0.304348732976503 3300 5418700 SGTC_2611 pyromycin 23.93 µM -0.512338788283672 0.294648261088493 no 2362 0.304206961506446 3291 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1905 st060207 84.5 µM -0.514303274250582 0.293958910386193 no 2363 0.303519986436395 3288 1948547 SGTC_447 ml7 120 µM -0.515787422852329 0.293438608184869 no 2364 0.303001443880927 3405 4216 Selective myosin light chain kinase inhibitor. SGTC_3193 9111931 49.47 µM -0.51581507842839 0.293428916940916 no 2365 0.302991785139283 3295 17087244 SGTC_746 1095-0025 46.6 µM -0.516451086008092 0.293206084021313 no 2366 0.30276969679361 3437 6749286 SGTC_1300 1094-0077 113 µM -0.516896485212441 0.293050079767743 no 2367 0.302614210664027 3323 5532636 SGTC_3103 9120822 49.47 µM -0.516941260556225 0.293034399013844 no 2368 0.302598581845803 3493 17141819 SGTC_1963 st076565 50.3 µM -0.518628376812402 0.292443838614883 no 2369 0.302009958314221 3324 4914280 SGTC_2289 7946404 165.07 µM -0.519092732239345 0.292281392178598 no 2370 0.301848038119602 3308 1246120 YPR165W RHO1 SGTC_1268 0828-0275 2.46 µM -0.519292388151621 0.292211559035613 no 2371 0.301778430331815 3392 745337 SGTC_3309 9129340 25.759 µM -0.519330216067926 0.292198328935834 no 2372 0.301765242867449 3334 17158987 SGTC_398 bronopol 33.3 µM -0.519361926982518 0.292187238437551 no 2373 0.301754188095047 3275 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1857 st056007 79.3 µM -0.519704808915737 0.292067332252901 no 2374 0.301634667323959 3403 619834 SGTC_1340 1486-1359 257 µM -0.521017660499819 0.291608438505327 no 2375 0.301177234363569 3300 4309068 SGTC_2626 ethyl orsellinate 100 µM -0.521140578993456 0.29156549082744 no 2376 0.301134422244249 3305 75653 A natural product. SGTC_68 0986-0284 82.829 µM -0.521339962446027 0.291495832593122 no 2377 0.301064983455737 3390 423278 YIL048W NEO1 SGTC_2956 9076196 2.52 µM -0.521737785681565 0.291356869011747 no 2378 0.30092645609754 3446 16423868 SGTC_1759 st043059 70 µM -0.521759273811008 0.291349363876167 no 2379 0.300918974462424 3283 669426 SGTC_3204 9114183 49.47 µM -0.527375018242378 0.289391059004252 no 2380 0.298966594098727 3311 17027248 SGTC_2203 7227154 166.4 µM -0.527552616820062 0.289329228388142 no 2381 0.298904943789315 3414 896304 SGTC_2557 derrustone 83.84 µM -0.528360886179737 0.289047909352109 no 2382 0.298624439883221 3415 629853 An antioxidant. SGTC_519 k048-0011 62.8 µM -0.529386161889067 0.288691246240994 no 2383 0.29826879785966 3378 6836379 SGTC_227 fluconazole 33.516 µM -0.530814031025563 0.288194878373858 no 2384 0.297773828011862 3374 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_596 1155-0152 116 µM -0.530898334203838 0.288165584785781 no 2385 0.297744616090565 3388 280313 SGTC_3141 9094609 49.47 µM -0.531075681141139 0.288103965027345 no 2386 0.297683167814796 3246 25236309 YDL196W YDL196W SGTC_2015 5119600 184 µM -0.531521937637535 0.287948939299403 no 2387 0.297528571679285 3441 2828786 SGTC_2185 6113692 200 µM -0.531751570722526 0.287869182060602 no 2388 0.297449034434607 3422 874150 SGTC_2699 st077704 54.6 µM -0.531967014433221 0.287794362628979 no 2389 0.297374420745981 3386 645852 SGTC_996 3970-0799 1.8 µM -0.532761098100716 0.287518672093589 no 2390 0.297099483043894 3409 6615648 YGL040C HEM2 SGTC_2952 9073731 13.78 µM -0.534021647917261 0.287081290131687 no 2391 0.296663278396437 3348 16457353 SGTC_360 0957-0399 1.01 µM -0.534639371213655 0.286867069362985 no 2392 0.2964496266096 3429 6752301 YPR165W RHO1 SGTC_711 k292-0785 179 µM -0.535701816361273 0.286498800423371 no 2393 0.296082324048822 3399 4146315 SGTC_659 k018-0002 107 µM -0.536246579521921 0.286310059495913 no 2394 0.295894072626876 3435 6797879 YHR007C ERG11 SGTC_441 propafenone 146 µM -0.536705515861431 0.286151100316917 no 2395 0.295735522675828 3345 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2622 2-methoxyxanthone 59.94 µM -0.537045371958977 0.286033413310257 no 2396 0.295618136854504 3340 71034 A hepatoprotective. SGTC_3140 9094243 49.47 µM -0.539812044548926 0.285076213404343 no 2397 0.294663329927424 3471 19291112 SGTC_2051 5263410 176 µM -0.540232389324361 0.284930918306993 no 2398 0.29451838922172 3489 227584 SGTC_544 k015-0020 52.4 µM -0.541901458743702 0.284354341684769 no 2399 0.293943195901868 3392 3008304 SGTC_2716 st080858 38.6235 µM -0.542842881476413 0.284029375254436 no 2400 0.293618992879525 3444 5296050 SGTC_10 0279-0212 42.575 µM -0.542896197449716 0.284010976616797 no 2401 0.293600637113108 3417 39851 YBR002C RER2 SGTC_2915 7971052 15.16 µM -0.542921766338851 0.284002153333439 no 2402 0.29359183437581 3354 5741558 SGTC_1571 st070080 73.4 µM -0.544656527058009 0.2834038305785 no 2403 0.292994884691299 3488 4315245 SGTC_3236 9132701 49.47 µM -0.54481708104637 0.28334848572466 no 2404 0.292939664833282 3404 24282524 SGTC_2790 5423970 71.43 µM -0.544910946865591 0.283316131470214 no 2405 0.292907383492547 3463 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3244 9134489 49.47 µM -0.545074457583269 0.283259775810315 no 2406 0.292851154557493 3411 16584271 SGTC_1192 1488-0095 21.4 µM -0.545287403926473 0.283186389712602 no 2407 0.29277793294969 3413 915875 SGTC_250 brefeldin a 552.239 µM -0.548088345505284 0.282221972279655 no 2408 0.291815621318451 3369 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_408 cantharidin 100 µM -0.54916742403526 0.281850847290534 no 2409 0.291445278950031 3373 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1457 k015-0032 57.3 µM -0.549410386673738 0.281767318158599 no 2410 0.291361923833392 3433 4302660 SGTC_3106 9121286 49.47 µM -0.550005815691528 0.281562663616567 no 2411 0.291157692335864 3506 15943471 SGTC_3256 9138902 49.47 µM -0.551022909468083 0.281213244862869 no 2412 0.290808984994895 3413 17228773 SGTC_778 3456-2434 196 µM -0.551636878257091 0.281002419586661 no 2413 0.290598582313606 3450 5539063 SGTC_1479 0549-0158 134 µM -0.551648492801353 0.280998432107892 no 2414 0.290594602779439 3427 5440202 SGTC_1248 0469-0687 58.6 µM -0.5518334914944 0.280934922466257 no 2415 0.290531219432204 3421 4017482 SGTC_2756 carbadox 75.1 µM -0.553131215337949 0.280489611875899 no 2416 0.290086781610318 3386 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1112 tnp00069 1.16933 µM -0.55333445599502 0.280419901324856 no 2417 0.290017205660428 3448 145826 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.553336268132503 0.280419279808293 no 2418 0.290016585341458 3378 688667 SGTC_2167 5876490 200 µM -0.553911823780273 0.28022191277154 no 2419 0.289819596401813 3477 686534 SGTC_3053 9095903 49.47 µM -0.553958238484717 0.280205999375974 no 2420 0.289803713299881 3469 17174018 SGTC_1885 st057546 99.9 µM -0.555116822524073 0.279808917916756 no 2421 0.289407378473779 3514 702008 SGTC_162 k030-0015 37.8 µM -0.55586586564308 0.279552343771826 no 2422 0.289151277272315 3428 1809920 YMR134W ERG29 SGTC_666 0272-0154 136 µM -0.556006142287295 0.279504306689642 no 2423 0.289103327907764 3403 6870312 SGTC_931 2812-0076 566 µM -0.556746772411419 0.279250747829545 no 2424 0.288850227719137 3368 3450959 SGTC_2344 7990960 76.95 µM -0.557190203364222 0.279098990285333 no 2425 0.288698741203469 3371 140813 SGTC_2975 9084847 53.72 µM -0.557740582739467 0.278910687050354 no 2426 0.288510770627555 3420 27211724 SGTC_1253 0550-0034 176 µM -0.558444869368359 0.278669817174062 no 2427 0.288270320397681 3447 5969915 SGTC_108 0509-0257 621.132 µM -0.560384028536463 0.278007137968913 no 2428 0.287608761619244 3410 536624 SGTC_2276 7947513 42.08 µM -0.560991786088095 0.277799604113359 no 2429 0.287401568349026 3388 2105100 SGTC_3070 9117005 49.47 µM -0.561096363606928 0.277763901161171 no 2430 0.28736592349309 3482 8779016 SGTC_573 3702-0553 84.7 µM -0.56197262286541 0.277464832758041 no 2431 0.287067336012958 3465 1222756 SGTC_462 ag-879 158 µM -0.563551701055402 0.276926289063751 no 2432 0.286529632508095 3471 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2016 5121758 140 µM -0.56417289743456 0.276714570764714 no 2433 0.286318235404549 3464 2795203 SGTC_1706 st031321 9.9705 µM -0.564904889762066 0.276465192439744 no 2434 0.286069228804397 3472 6103185 SGTC_3130 9127414 49.47 µM -0.564911317331935 0.27646300315552 no 2435 0.286067042751878 3455 1494646 SGTC_1429 4049-0205 9.46 µM -0.565012411794491 0.276428570651813 no 2436 0.286032661003098 3491 22774478 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.565170252742939 0.27637481465232 no 2437 0.285978983969526 3312 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.565514424390082 0.276257617662664 no 2438 0.285861957986097 3486 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1704 st028805 70.8 µM -0.565782666713352 0.276166292964096 no 2439 0.285770765446644 3436 2876101 SGTC_2413 inermin 26.06 µM -0.566569645064703 0.275898447031515 no 2440 0.285503301582543 3558 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1393 3470-5649 58.2 µM -0.566790226954173 0.275823395491742 no 2441 0.285428355616791 3396 4108395 SGTC_1646 st011709 75.6 µM -0.567809389300118 0.275476762501321 no 2442 0.285082201797493 3468 5757843 SGTC_1880 MG-132 525 µM -0.568380238092987 0.27528270160454 no 2443 0.284888403103125 3465 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2601 securinine 100 µM -0.570015867023232 0.274727040003199 no 2444 0.284333468177301 3373 442872 A GABA receptor antagonist. SGTC_102 gallobenzophenone 83.616 µM -0.571366455221728 0.274268630694899 no 2445 0.283875631420681 3531 70837 SGTC_2568 diosmetin 100 µM -0.571719774032927 0.274148771502344 no 2446 0.283755917907943 3511 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3174 9107204 49.47 µM -0.571915184565569 0.274082491924349 no 2447 0.283689718170816 3500 3938802 SGTC_675 1309-0189 238 µM -0.571981984136946 0.274059836581843 no 2448 0.283667090001974 3413 4246530 SGTC_2909 7941780 10.49 µM -0.574280871483652 0.273280724078914 no 2449 0.282888875633027 3518 1243215 SGTC_707 0865-0008 204 µM -0.57503860101241 0.273024163703164 no 2450 0.282632595518337 3458 723043 SGTC_2032 5185112 25.99 µM -0.575747443114687 0.272784264313739 no 2451 0.282392951231724 3390 5718189 SGTC_1555 citronellol 128 µM -0.576649174932743 0.272479234846495 no 2452 0.282088236401877 3471 8842 A terpine precursor. SGTC_2712 st079126 47.7 µM -0.57754782633594 0.272175415996388 no 2453 0.28178472010568 3448 3152970 SGTC_1990 st072050 59.8 µM -0.577822368988325 0.272082631355914 no 2454 0.281692025705789 3423 17233948 SGTC_2038 4100038 30.985 µM -0.579306876464207 0.271581198679559 no 2455 0.281191063217542 3477 3596803 SGTC_3134 9127454 49.47 µM -0.579968941190024 0.271357716831007 no 2456 0.280967781400692 3575 24262820 SGTC_21 0849-0113 22.993 µM -0.581606605390219 0.270805312570992 no 2457 0.280415846331352 3450 1560156 SGTC_2918 7977171 22.06 µM -0.582092794213496 0.270641423234098 no 2458 0.280252089269826 3451 2236483 SGTC_1899 st063254 59.6 µM -0.584046508543042 0.269983345758593 no 2459 0.279594510948541 3439 3093813 SGTC_1315 1237-0019 3.69 µM -0.584528426876536 0.269821142474619 no 2460 0.279432422817664 3507 825140 SGTC_1024 4507-0395 26 µM -0.584589185016528 0.269800696063368 no 2461 0.279411990700517 3550 4201836 SGTC_2934 9036370 36.88 µM -0.585644811455929 0.269445579110632 no 2462 0.279057114095851 3456 6462800 SGTC_1746 st038117 42 µM -0.589329176988384 0.268207982632008 no 2463 0.277820237970379 3479 2898218 SGTC_878 0828-0289 13.7 µM -0.589432208860813 0.268173414875488 no 2464 0.277785687711352 3516 745350 YLR208W SEC13 SGTC_2471 5466956 24.79 µM -0.589531223769074 0.268140196945128 no 2465 0.277752486460653 3411 724419 SGTC_2393 9031399 185.94 µM -0.58997361616198 0.26799180661778 no 2466 0.277604169033058 3557 1526623 YDL150W RPC53 SGTC_512 prima-1 270 µM -0.591131615506792 0.267603578309352 no 2467 0.277216118982839 3529 322968 A re-activator of the apoptotic function of mutant p53. SGTC_148 3253-0744 288.01 µM -0.591334465083716 0.267535600600451 no 2468 0.277148170628901 3504 6893655 SGTC_455 paf C-16 10 µM -0.593207573221866 0.266908307736329 no 2469 0.276521122481458 3482 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1630 st005209 31.3 µM -0.594895259027307 0.266343748743103 no 2470 0.275956743278575 3534 3367314 SGTC_2416 tofa 880 nM -0.598390472483479 0.265176466460984 no 2471 0.274789710742638 3396 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2480 5767542 37.17 µM -0.599633577458771 0.264761938906512 no 2472 0.274375232176285 3507 2867358 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.601310154304225 0.26420338751919 no 2473 0.27381671377663 3524 676296 Flavone; oxidizing agent. SGTC_620 0109-0052 432 µM -0.601333409265177 0.264195644353492 no 2474 0.273808970801421 3542 493037 SGTC_3051 9093778 49.47 µM -0.602006092319287 0.263971712233495 no 2475 0.273585041029584 3500 17217378 SGTC_2414 st077232 92.9 µM -0.602364999802764 0.263852273690919 no 2476 0.273465601239405 3408 729801 SGTC_150 3970-0969 77.2 µM -0.603004857815017 0.263639407773859 no 2477 0.273252728783006 3527 6615640 SGTC_2674 ligustilide 100 µM -0.603101966438543 0.263607109646455 no 2478 0.273220429179987 3497 5319022 A signalling regulator. SGTC_356 1634-0012 32.5 µM -0.604134345521536 0.26326386735942 no 2479 0.272877163334556 3532 735457 SGTC_2635 hydroquinidine 100 µM -0.606840783914677 0.262365123738853 no 2480 0.271978289682894 3511 442912 An experimental heart treatment. SGTC_1321 1326-2144 215 µM -0.609109433728132 0.261612971651528 no 2481 0.271225952501613 3511 3513030 SGTC_2872 9044037 25.97 µM -0.610406067251011 0.261183581091445 no 2482 0.270796425007975 3510 6465195 SGTC_1864 st057645 30.4 µM -0.612015322817339 0.260651167377454 no 2483 0.270263809861231 3581 688666 SGTC_460 trequinsin 123 µM -0.613490903906558 0.260163470556764 no 2484 0.269775897710256 3564 5537 A vasodilator. SGTC_3331 9141060 1.957 µM -0.614563231811449 0.259809348965348 no 2485 0.269421601259852 3488 4906567 YPR165W RHO1 SGTC_103 0844-0104 51.839 µM -0.614852792541172 0.259713768167583 no 2486 0.269325970593723 3590 5375804 SGTC_2047 4141938 200 µM -0.615710579218417 0.259430728812018 no 2487 0.269042776894827 3496 3807862 SGTC_2372 9071633 200 µM -0.615877589919824 0.259375639706648 no 2488 0.268987656588761 3573 21321366 SGTC_2147 5545932 89.7195 µM -0.616135880074111 0.259290453634111 no 2489 0.268902421524774 3529 797404 SGTC_771 0250-0039 27.3 µM -0.61670058195458 0.259104260995716 no 2490 0.268716118653889 3479 3005115 SGTC_158 k038-0087 26.446 µM -0.617304135275358 0.258905334773844 no 2491 0.268517069879658 3499 X158 SGTC_428 3448-4153 16.5 µM -0.618330785961627 0.258567140726364 no 2492 0.26817865613139 3492 3834874 SGTC_3065 9113888 49.47 µM -0.620198648599157 0.257952426162433 no 2493 0.267563505563481 3618 16648368 SGTC_3127 9126946 49.47 µM -0.620848058796113 0.257738882681819 no 2494 0.267349799528703 3471 27243249 SGTC_2350 9023895 38.85 µM -0.622632619506795 0.257152544191362 no 2495 0.266762985223559 3546 2997209 SGTC_565 1418-0001 44.5 µM -0.623202299760104 0.256965515169786 no 2496 0.26657579532122 3584 2862145 SGTC_2826 7992541 19.48 µM -0.626574310141697 0.255859917326654 no 2497 0.265469156203756 3604 2985066 SGTC_516 3992-2719 87.3 µM -0.626638269730541 0.25583897059545 no 2498 0.265448188251165 3481 5350887 YDR037W KRS1 SGTC_643 k048-0106 28.4 µM -0.626943604292134 0.255738986026452 no 2499 0.265348101619884 3562 6763920 SGTC_890 0929-0006 47.2 µM -0.627161376233543 0.255667687096847 no 2500 0.265276729135115 3507 1378169 SGTC_314 1671-0008 2.74 µM -0.627477217058625 0.255564298683808 no 2501 0.265173232915882 3501 3913060 SGTC_1912 st060209 90.8 µM -0.628487431241681 0.255233758421287 no 2502 0.264842338879911 3523 688787 SGTC_107 0358-0022 2.6945 µM -0.629035422990185 0.255054550064126 no 2503 0.264662932910662 3525 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1919 st067113 52.3 µM -0.630053965136275 0.254721633752212 no 2504 0.264329638640095 3551 1268243 SGTC_3026 9090633 49.47 µM -0.630592118490287 0.254545827171268 no 2505 0.26415362676671 3531 25236842 SGTC_96 0929-0093 37.281 µM -0.631082112127836 0.254385808949087 no 2506 0.263993418259938 3532 6991579 SGTC_2426 5582046 32.21 µM -0.632392970471 0.253957978595983 no 2507 0.26356506308962 3591 2251934 SGTC_1707 st032323 6.317 µM -0.633508872930933 0.253594074556444 no 2508 0.263200694217781 3514 3132057 YMR211W DML1 SGTC_562 3772-2733 112 µM -0.634670665883428 0.253215496533139 no 2509 0.262821614600557 3584 2876874 YIL048W NEO1 SGTC_169 k015-0017 16.025 µM -0.6348598853996 0.253153866240774 no 2510 0.262759900910293 3629 1840002 SGTC_1786 berberine 21.6 µM -0.635241604192245 0.253029561427498 no 2511 0.262635426403335 3560 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_212 3807-4682 38.772 µM -0.637843041207488 0.252183272417214 no 2512 0.261787929229725 3646 3125501 YBL034C STU1 SGTC_2020 4017018 200 µM -0.639714061965929 0.251575523686077 no 2513 0.261179255861584 3578 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1732 st034308 51.822 µM -0.641323221274593 0.251053452882528 no 2514 0.260656352593495 3518 830119 SGTC_351 caspofungin 25 nM -0.641935520545595 0.250854951004644 no 2515 0.260457524917322 3615 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_481 bay k-8644 50 µM -0.642190211149909 0.250772407091662 no 2516 0.260374844019361 3522 2303 A calcium channel antagonist. SGTC_979 1426-2828 121 µM -0.642410922446687 0.250700887330363 no 2517 0.260303204851997 3625 747872 SGTC_1937 st074714 47.2 µM -0.643231379825921 0.250435119306367 no 2518 0.26003698728421 3523 17250970 SGTC_3231 9132313 49.47 µM -0.643704667828012 0.250281876641052 no 2519 0.259883481231192 3570 4905967 SGTC_1650 st011916 45.8 µM -0.64376921795615 0.250260980252797 no 2520 0.259862548689994 3586 242528 SGTC_2835 9006588 71.43 µM -0.644576632981034 0.249999679274407 no 2521 0.259600790827058 3608 2345538 SGTC_556 4058-0063 51.5 µM -0.645310958655656 0.249762157719906 no 2522 0.259362846236831 3634 6615692 SGTC_943 3253-1379 105 µM -0.64693262251262 0.24923804668873 no 2523 0.258837775656553 3595 668464 SGTC_389 tpck 16.7 µM -0.647208442778739 0.249148961634425 no 2524 0.258748523929454 3568 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1996 st072960 66.8 µM -0.647486763003429 0.249059086307924 no 2525 0.258658479397848 3600 1719405 SGTC_585 0kpi-0023 191 µM -0.647505756828225 0.24905295343992 no 2526 0.258652334945121 3550 64601 SGTC_1079 idarubicin 2.36 µM -0.648134346126416 0.24885003516911 no 2527 0.258449030589078 3572 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_36 0335-0881 14.2 µM -0.648299150071898 0.248796848492535 no 2528 0.258395741822632 3548 23828853 SGTC_1085 doxorubicin 7.67 µM -0.648497250405456 0.248732924184563 no 2529 0.25833169432297 3612 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2569 tetrandrine 100 µM -0.648562567736898 0.248711849079376 no 2530 0.258310578485311 3540 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2099 5377090 177.372 µM -0.648689028936721 0.248671048169795 no 2531 0.258269698552855 3570 2243829 SGTC_2519 cryptotanshinone 88.04 µM -0.650269323138756 0.248161489447731 no 2532 0.25775913449054 3588 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_501 nsc-95397 161 µM -0.651010766452072 0.24792260648028 no 2533 0.257519768450251 3614 262093 SGTC_183 3914-0051 30.55 µM -0.651927125760947 0.247627537606788 no 2534 0.257224092497878 3589 1596232 SGTC_2339 9000433 200 µM -0.652713880296967 0.247374351373024 no 2535 0.256970376192694 3549 2988954 SGTC_622 1348-1566 26.3 µM -0.654835220462887 0.246692370942627 no 2536 0.256286925783204 3610 7340407 SGTC_1266 0828-0227 32.9 µM -0.65595591077138 0.24633249195119 no 2537 0.255926246235536 3571 3913820 SGTC_1015 4130-4525 82 µM -0.656615753081413 0.246120733368842 no 2538 0.255714008552691 3563 1363237 SGTC_1570 verbenone 133 µM -0.65809197569927 0.245647333334881 no 2539 0.255239515876751 3628 29025 A natural terpanoid with antifungal properties. SGTC_3125 9127534 49.47 µM -0.658508011336192 0.245514006009324 no 2540 0.255105875432162 3505 1639235 SGTC_1342 1486-1464 234 µM -0.658577516993877 0.245491735257583 no 2541 0.255083552146464 3633 3253938 SGTC_2784 7567673 72.73 µM -0.659785825862458 0.245104746798773 no 2542 0.254695640256488 3639 3471247 SGTC_1722 st034304 3.6505 µM -0.661734775444215 0.244481243314926 no 2543 0.254070606836326 3623 4036148 YLR033W RSC58 SGTC_887 0885-0007 9.62 µM -0.662572215761806 0.244213594031049 no 2544 0.253802284817204 3629 5719458 SGTC_2329 6138490 200 µM -0.662958592939864 0.244090159613738 no 2545 0.253678536907465 3602 720019 SGTC_2807 7945238 51.95 µM -0.663183516111929 0.244018319778861 no 2546 0.253606513674982 3631 17148797 SGTC_235 0330-0087 5 mM -0.66386251584161 0.243801518358944 no 2547 0.253389154582674 3628 46494818 YHR062C RPP1 SGTC_2043 5101342 149 µM -0.664827677271264 0.243493525863224 no 2548 0.253080358969065 3602 678451 SGTC_1130 3454-2858 15.9 µM -0.666201562932853 0.243055468235645 no 2549 0.252641137038562 3592 715628 YIL048W NEO1 SGTC_3031 9088762 49.47 µM -0.666712442565595 0.242892685207297 no 2550 0.252477914750439 3593 205253 SGTC_970 1315-0089 19.5 µM -0.668698701626291 0.242260358725288 no 2551 0.251843847964337 3578 6811083 YLR033W RSC58 SGTC_465 cgp-37157 41 µM -0.671484295377716 0.241375068793492 no 2552 0.250956030373368 3550 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1077 5-fluorocytosine 377 nM -0.671510851072174 0.241366637590559 no 2553 0.250947574585375 3614 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3238 9133470 49.47 µM -0.673467856221672 0.240745745990969 no 2554 0.250324845846585 3648 3534688 SGTC_305 1682-2595 20.8 µM -0.673909954102109 0.240605603725396 no 2555 0.250184281636115 3638 226033 SGTC_1061 3448-9325 110 µM -0.675010095781396 0.240257058535873 no 2556 0.249834675384251 3598 723482 SGTC_1795 st049545 62.3 µM -0.675681379602912 0.240044518662561 no 2557 0.249621480317214 3599 5291882 SGTC_619 1652-1634 108 µM -0.675983749721769 0.239948816638282 no 2558 0.249525481251131 3597 5400454 SGTC_1889 st059080 5.18 µM -0.678330040929242 0.239206908523708 no 2559 0.248781227706167 3643 176925 Isolated from Daphnopsis sellowiana. SGTC_841 0251-0215 91.2 µM -0.678420732957856 0.239178256469126 no 2560 0.248752483553828 3674 3888614 SGTC_397 arbidol 50 µM -0.678979429999908 0.23900179039566 no 2561 0.248575447762753 3672 131410 A RNA synthesis inhibitor. SGTC_1131 3454-3128 32.3 µM -0.679258909340605 0.238913542756221 no 2562 0.248486913607167 3692 710982 SGTC_2726 cimetidine 79.27 µM -0.681092648568914 0.238334968468279 no 2563 0.24790643421424 3648 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.681744018094065 0.238129635739147 no 2564 0.247700414246894 3672 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1178 0988-0033 191 µM -0.682116956840952 0.238012117045152 no 2565 0.247582499596911 3657 5392207 SGTC_24 0417-1663 219 µM -0.682216935434842 0.237980617668095 no 2566 0.247550893763748 3629 4329390 SGTC_2163 5671233 125 µM -0.682620892411015 0.237853369767072 no 2567 0.247423214412349 3688 701023 SGTC_3147 9097027 49.47 µM -0.683439455789256 0.237595633803629 no 2568 0.24716459767982 3670 25236841 SGTC_2792 7535235 81.82 µM -0.684411089488993 0.237289900569232 no 2569 0.246857807691032 3619 1281891 SGTC_2343 7990716 14.84 µM -0.684969385961132 0.237114325379229 no 2570 0.246681619756982 3637 6456862 SGTC_2984 9022109 38.96 µM -0.685142034483893 0.237060044671037 no 2571 0.246627148744962 3694 6459207 SGTC_1122 capsaicin 818.572 nM -0.685263359110465 0.237021904285255 no 2572 0.24658887439661 3694 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1292 0kpi-0043 232 µM -0.687880124018653 0.236200102648724 no 2573 0.245764137020431 3660 3333905 SGTC_806 3966-4455 5.86 µM -0.689335577792819 0.235743693771345 no 2574 0.245306056930587 3610 714982 SGTC_760 0568-0725 82.9 µM -0.692014827124897 0.234904793666497 no 2575 0.244464008840247 3666 3916171 SGTC_73 0327-0325 16.231 µM -0.692856656315987 0.234641549434539 no 2576 0.244199756374468 3687 53298 SGTC_891 0929-0073 133 µM -0.693761961062815 0.234358638224873 no 2577 0.243915750712592 3685 5603632 SGTC_1915 st067105 30.6 µM -0.693823435438591 0.234339434093405 no 2578 0.243896471879818 3662 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3285 9112818 20.8695 µM -0.694549211394317 0.234112773007761 no 2579 0.243668925178945 3699 17017947 YPR165W RHO1 SGTC_653 0203-0016 55.2 µM -0.695888999035358 0.233694674108508 no 2580 0.243249173611756 3695 295302 SGTC_266 formosanin C 406 nM -0.699999062797218 0.232414659244787 no 2581 0.241963944868424 3651 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1851 st056236 18.9 µM -0.702643691759945 0.231593097269797 no 2582 0.241138913393271 3685 5393171 SGTC_1909 st060837 51.5 µM -0.703263336243414 0.231400837168196 no 2583 0.240945827421928 3673 678937 SGTC_657 3534-0529 86.7 µM -0.703410836106923 0.231355084788028 no 2584 0.240899877727975 3698 1049549 SGTC_538 2922-0838 53.3 µM -0.703941353057012 0.231190567615451 no 2585 0.240734648570006 3706 777039 SGTC_1284 0929-0043 16 µM -0.709168712120641 0.229573020257179 no 2586 0.239109893495598 3686 1239883 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.711307530050974 0.228913019505598 no 2587 0.238446843189073 3712 2724 A muscle relaxant with antifungal properties. SGTC_1411 3909-8223 150 µM -0.711522452051749 0.228846757368255 no 2588 0.23838027139361 3696 X1411 SGTC_598 3937-0236 20.2 µM -0.71291905996669 0.228416434577577 no 2589 0.237947922069638 3758 1379313 SGTC_2773 thioridazine 9.09 µM -0.714381827831404 0.227966214483953 no 2590 0.237495552868677 3709 5452 An antipsychotic. SGTC_1643 st009866 20.2 µM -0.717757827402723 0.226929035597064 no 2591 0.236453310322435 3692 3156273 YOR207C RET1 SGTC_1951 sophoraflavanone G 9.2 µM -0.720132187832228 0.226201178546676 no 2592 0.235721805525078 3720 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_847 0342-0274 5.54 µM -0.720338869608958 0.226137882991029 no 2593 0.235658189070451 3718 18097 SGTC_1244 0416-0015 52.5 µM -0.721348197973389 0.225828923615623 no 2594 0.235347654836607 3720 96201 SGTC_168 3970-0862 530.542 µM -0.72147923396214 0.225788830500693 no 2595 0.235307356322381 3709 3135186 SGTC_2652 actinonin 100 µM -0.721812015364239 0.225687027387915 no 2596 0.23520503059969 3691 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_322 k048-0136 19.3 µM -0.723797584897094 0.225080150149112 no 2597 0.23459500613093 3728 6823282 SGTC_348 k064-0012 10.7 µM -0.724726313066037 0.224796607742493 no 2598 0.234309974587102 3656 5066323 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.725877162639973 0.224445532412557 no 2599 0.233957038902503 3685 7104 SGTC_2515 chrysin 20.77 µM -0.727464967604905 0.22396167173683 no 2600 0.233470584187046 3734 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_3233 9132340 49.47 µM -0.72867050559784 0.223594697576254 no 2601 0.233101619353574 3719 17682950 SGTC_668 1682-0499 62.6 µM -0.728777745236913 0.223562069654595 no 2602 0.233068813466316 3747 682214 SGTC_1158 4092-0494 91.8 µM -0.728862651370656 0.223536238677242 no 2603 0.233042841483752 3840 1148199 SGTC_1224 0823-0416 294 µM -0.730922844209806 0.22290998714275 no 2604 0.232413140837889 3762 3598164 SGTC_1717 st033143 58.0435 µM -0.73096389160396 0.222897519836729 no 2605 0.232400604271095 3712 674616 SGTC_2455 5377712 9.75 µM -0.73216474234881 0.222532961840629 no 2606 0.232034010698581 3705 2243908 SGTC_2833 9001315 45.46 µM -0.733039563058889 0.222267595245926 no 2607 0.23176714982295 3726 2989378 SGTC_442 cape 100 µM -0.733226909269886 0.222210789454184 no 2608 0.23171002278088 3682 5281787 SGTC_1330 1469-0054 61.8 µM -0.735904572562523 0.221399793262412 no 2609 0.230894387167641 3745 7102664 SGTC_901 1112-0062 60.1 µM -0.736369019854986 0.221259296411591 no 2610 0.230753076490344 3731 1908457 SGTC_1945 st075991 56.6 µM -0.73658758751902 0.221193196616501 no 2611 0.230686592779908 3680 1084980 SGTC_1946 st076057 65.1 µM -0.736845618040629 0.221115176904828 no 2612 0.230608119069624 3619 953009 SGTC_3298 9116858 71.43 µM -0.736963346073208 0.221079585157173 no 2613 0.230572319906585 3751 2506942 SGTC_2950 9072895 21.46 µM -0.738060646102712 0.22074800518452 no 2614 0.230238798385384 3690 17332245 SGTC_1097 itavastatin 7.23 µM -0.73831689527986 0.220670613351846 no 2615 0.230160950988956 3745 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2194 5927483 104.545 µM -0.73870894790622 0.220552236534286 no 2616 0.23004187559229 3762 760979 SGTC_1352 1496-0991 99 µM -0.73919908505095 0.220404295156038 no 2617 0.229893058172778 3736 3000039 SGTC_2174 5790901 200 µM -0.739503996026172 0.220312290539389 no 2618 0.229800507069089 3766 786020 SGTC_1927 st060202 13.8 µM -0.739776717816348 0.220230017427397 no 2619 0.229717744182727 3687 688887 SGTC_2172 5754775 163.918 µM -0.740252816520632 0.220086432991544 no 2620 0.229573302516894 3706 2263357 SGTC_2380 9035439 200 µM -0.740799141054596 0.219921735651692 no 2621 0.229407618032675 3834 6462575 SGTC_1056 3448-1962 115 µM -0.741777219189203 0.219627056741653 no 2622 0.229111162591353 3759 715507 SGTC_624 k048-0052 28 µM -0.741842845225046 0.219607292813538 no 2623 0.229091279038308 3722 6835531 SGTC_710 3448-4187 58 µM -0.744097452635936 0.218928916131768 no 2624 0.228408760157802 3760 3946412 SGTC_1203 3992-3522 103 µM -0.744114414892112 0.21892381702268 no 2625 0.228403629646634 3848 5322312 SGTC_3352 9151559 45.5865 µM -0.745550255945433 0.218492429350767 no 2626 0.22796957090211 3746 17159339 SGTC_17 0960-0276 49.807 µM -0.746527887697561 0.218198987546844 no 2627 0.227674295830399 3740 6821114 SGTC_1240 0356-0016 42.1 µM -0.747312383629938 0.21796368089801 no 2628 0.227437509541885 3749 4305613 SGTC_1954 st077032 68.9 µM -0.747366230780843 0.217947535012385 no 2629 0.227421261816204 3654 698907 SGTC_222 nsc-310342 10.666 µM -0.749209178398969 0.217395349276425 no 2630 0.226865568976348 3702 432556 SGTC_3187 9109394 49.47 µM -0.750116684613787 0.217123738472532 no 2631 0.226592215809464 3710 17098090 SGTC_1944 st076371 56.9 µM -0.751639534927283 0.216668399936208 no 2632 0.226133930690521 3768 24208455 SGTC_932 2857-0803 154 µM -0.752272394797712 0.216479334795322 no 2633 0.22594363262727 3863 674898 SGTC_772 k072-0172 35.3 µM -0.753804922533526 0.216021892063035 no 2634 0.225483183866986 3786 5861980 SGTC_2970 9090938 41.86 µM -0.753930164279423 0.215984533540963 no 2635 0.225445578410214 3752 17217104 SGTC_810 3825-7150 143 µM -0.757686548373096 0.214865777727452 no 2636 0.224319326871182 3787 22330411 YGL099W LSG1 SGTC_949 1165-0505 146 µM -0.757722687320706 0.214855030916395 no 2637 0.224308507106901 3804 6244267 SGTC_1780 st038448 24.544 µM -0.757938765809102 0.214790781141821 no 2638 0.224243820804169 3838 728868 YDL195W SEC31 SGTC_2187 6125751 200 µM -0.758246097053127 0.214699417083978 no 2639 0.224151834883006 3780 874498 SGTC_2850 9015429 58.44 µM -0.758448431838805 0.21463927891762 no 2640 0.224091286675885 3825 6457570 SGTC_978 1416-0512 87.4 µM -0.759889994586731 0.214211099508339 no 2641 0.223660171394434 3829 6814003 SGTC_2191 5911152 200 µM -0.761186077332285 0.213826555818742 no 2642 0.223272966456996 3776 2875902 SGTC_3242 9133940 49.47 µM -0.761585606861879 0.213708097766838 no 2643 0.22315368391963 3789 17248444 SGTC_677 0929-0063 136 µM -0.762862121978179 0.21332987514718 no 2644 0.2227728139967 3737 1539583 SGTC_3011 9081274 71.4286 µM -0.763693540933454 0.213083741458278 no 2645 0.222524945399297 3776 6625322 SGTC_1868 st057644 42.7 µM -0.763939490896379 0.213010962070549 no 2646 0.222451651179921 3777 688665 SGTC_2101 5377231 179.231 µM -0.767286477493788 0.212021993252697 no 2647 0.221455603279031 3821 2844213 SGTC_2697 mebhydrolin 72.4 µM -0.768745213988124 0.211591806845556 no 2648 0.221022289041769 3789 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2177 5811945 192 µM -0.76897007825511 0.211525539083864 no 2649 0.22095553683291 3815 5343475 SGTC_2696 st077691 74.316 µM -0.769808324236257 0.211278614121412 no 2650 0.220706800563951 3772 757133 SGTC_1621 st003705 32.4 µM -0.770304920564191 0.211132409745409 no 2651 0.220559519120089 3819 24207032 SGTC_3300 9124615 50.48 µM -0.770402789059171 0.211103602991472 no 2652 0.220530499747554 3808 24824903 SGTC_2160 5660466 132.927 µM -0.773044286021426 0.21032697146908 no 2653 0.219748085908426 3726 2859134 SGTC_23 0213-0011 39.996 µM -0.773163505268218 0.210291959204333 no 2654 0.219712810684074 3806 627608 SGTC_83 0170-0301 39.027 µM -0.773665287305833 0.210144633560158 no 2655 0.219564376391545 3725 3089716 SGTC_291 SEC14.278 35.5 µM -0.774599067654589 0.20987063256078 no 2656 0.21928830420525 3773 1068044 SGTC_529 4076-0302 30.3 µM -0.778469134093034 0.208737272212544 no 2657 0.21814624804333 3771 5816522 SGTC_423 5-fluorouracil 457 µM -0.778601988092911 0.208698429673077 no 2658 0.218107103797406 3774 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2612 dictamnine 15.46 µM -0.779710604301174 0.208374469553989 no 2659 0.217780617807754 3790 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.779841476437882 0.208336245648206 no 2660 0.217742094751691 3826 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2228 7354201 200 µM -0.780039895642936 0.208278301118366 no 2661 0.217683696280041 3813 753451 SGTC_1450 4112-4260 37.6 µM -0.781399791061332 0.20788142565871 no 2662 0.217283696987947 3771 1633175 SGTC_2982 9019404 25.97 µM -0.781924174421713 0.207728507618692 no 2663 0.217129568474808 3756 22333232 SGTC_1302 1159-0335 255 µM -0.784372694782848 0.207015362429099 no 2664 0.216410727741523 3826 649284 SGTC_1974 st069448 26.9 µM -0.784956153581703 0.20684564077631 no 2665 0.216239638351099 3789 6323587 YNR016C ACC1 SGTC_1498 4478-3555 97.6 µM -0.785161918341307 0.20678580575523 no 2666 0.216179320011683 3771 3437919 SGTC_2724 maprotiline 69.64 µM -0.785169661305883 0.206783554352793 no 2667 0.216177050412051 3755 4011 A tricyclic antidepressant. SGTC_698 k064-0052 127 µM -0.786115377649288 0.206508679920275 no 2668 0.21589994803116 3862 5088751 SGTC_1865 st057639 52.2 µM -0.786571999521849 0.206376039340178 no 2669 0.215766227918875 3801 688818 SGTC_217 ketoconazole 989 nM -0.786580376409932 0.206373606473972 no 2670 0.215763775225121 3717 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_644 1498-1197 63.3 µM -0.787144083840382 0.206209930227261 no 2671 0.215598762803483 3875 6741615 SGTC_1623 st003709 20.3 µM -0.787760874003014 0.206030929244581 no 2672 0.215418295497591 3799 16192618 SGTC_1861 st057647 17.4 µM -0.788694919294159 0.205760031967411 no 2673 0.215145169075344 3875 688668 SGTC_1495 4469-0029 237 µM -0.78871927950371 0.205752969706276 no 2674 0.215138048538888 3809 793680 SGTC_934 2950-0684 338 µM -0.790064414122679 0.205363225436907 no 2675 0.214745075474937 3864 1121253 SGTC_214 4373-3496 70 µM -0.792300605065593 0.204716274495707 no 2676 0.21409270948897 3891 3779166 SGTC_341 1486-1430 230 µM -0.793737410507808 0.204301233719196 no 2677 0.213674158237635 3791 2054753 YPL210C SRP72 SGTC_3173 9105693 49.47 µM -0.793769852400822 0.204291868225052 no 2678 0.21366471319859 3838 17096658 SGTC_777 1315-0167 517 µM -0.793982703743677 0.204230427534923 no 2679 0.213602750306274 3863 4221767 SGTC_8 0354-0001 70 µM -0.794488957264178 0.204084338937869 no 2680 0.213455417538009 3833 4993152 SGTC_463 ikarugamyin 104 µM -0.79481316975658 0.203990814274223 no 2681 0.213361094501407 3862 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_801 0866-0028 10.1 µM -0.797895039315877 0.203103071828725 no 2682 0.212465701182947 3827 6849771 SGTC_1594 piperine 70.1 µM -0.798498111213254 0.202929625254332 no 2683 0.212290744398513 3801 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2002 4023503 131 µM -0.800059806407883 0.202480885059797 no 2684 0.211838073586704 3841 4736863 YCR052W RSC6 SGTC_2031 5180455 200 µM -0.800319754609861 0.202406248731256 no 2685 0.211762780222106 3811 29949 SGTC_401 neomycin 50 µM -0.800326340465289 0.202404358014131 no 2686 0.211760872848522 3813 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_869 0564-0080 44.1 µM -0.801269354960008 0.202133739326363 no 2687 0.211487863917115 3849 6843321 SGTC_293 4049-0273 38.5 µM -0.802310352963192 0.201835253667361 no 2688 0.211186727577974 3734 1380311 SGTC_170 4197-0004 226 µM -0.802879401685894 0.201672201783402 no 2689 0.211022221379111 3870 218692 SGTC_700 3453-2283 142 µM -0.805845022018213 0.200823728133597 no 2690 0.210166107364957 3888 565664 SGTC_1037 k284-1091 78.7 µM -0.805925363762121 0.200800771942684 no 2691 0.210142942763135 3796 3334711 SGTC_1877 wortmannin 25 µM -0.809888376621566 0.199670368952905 no 2692 0.209002166408842 3844 312145 A covalent inhibitor of PI 3-kinase. SGTC_987 1497-1013 404 µM -0.810790377178499 0.199413619783131 no 2693 0.208743030766612 3822 1676435 SGTC_2824 7998404 51.95 µM -0.811414376584887 0.199236118377364 no 2694 0.208563872901455 3816 837851 SGTC_2118 5526350 200 µM -0.811418315696196 0.199234998169342 no 2695 0.208562742222423 3905 743594 SGTC_736 0958-0254 92.6 µM -0.811985130315497 0.199073846464572 no 2696 0.208400081931895 3926 6812352 SGTC_3028 9087778 49.47 µM -0.813122731852462 0.198750650756764 no 2697 0.208073847280133 3835 17217395 SGTC_2823 7987624 58.44 µM -0.814094913685071 0.198474702098398 no 2698 0.207795289737921 3836 2239440 SGTC_1226 3909-7979 35.4 µM -0.814171501870573 0.198452972774439 no 2699 0.207773354423795 3877 6615510 SGTC_2772 vinpocetine 57.06 µM -0.815491970097949 0.198078560029183 no 2700 0.207395379545532 3844 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2551 apiole 73.87 µM -0.816278397127888 0.197855775034623 no 2701 0.207170463526958 3678 10659 A possible DNA adduct former. SGTC_3243 9134147 49.47 µM -0.816638363446435 0.197753851577687 no 2702 0.2070675622771 3896 24282180 SGTC_2566 crystal violet carbinol 226 nM -0.816643348062729 0.197752440420265 no 2703 0.207066137569284 3894 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_215 1287-0124 461.5 µM -0.819196712443611 0.19703037667191 no 2704 0.206337095147153 3876 5560863 SGTC_2023 5144124 124 µM -0.820000888429504 0.196803295271139 no 2705 0.206107800351195 3861 2830192 SGTC_2678 equilin 100 µM -0.822165392176082 0.196192875418547 no 2706 0.205491386213343 3869 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2791 5663188 71.43 µM -0.822447025545636 0.196113535426018 no 2707 0.205411262341734 3873 54690634 SGTC_2732 terfenadine 20 µM -0.822598193446792 0.196070957376394 no 2708 0.205368263168337 3862 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2539 epi(13)torulosol 80 µM -0.82312571510238 0.19592241921073 no 2709 0.205218253389696 3893 6708597 SGTC_719 2810-4230 27.3 µM -0.823270998761385 0.195881522612916 no 2710 0.205176950940552 3846 721079 SGTC_1651 st011928 86.1 µM -0.824177728538574 0.195626399943187 no 2711 0.204919289876111 3877 720198 SGTC_52 0329-0193 875 nM -0.824233556835941 0.19561069837038 no 2712 0.204903431705584 3958 3739292 SGTC_2871 9038510 12.99 µM -0.824296266189096 0.195593062429857 no 2713 0.204885619823735 3827 4945164 SGTC_3189 9110682 49.47 µM -0.825308735666451 0.195308456229413 no 2714 0.204598166779334 3958 17122418 SGTC_1422 4031-0024 15.5 µM -0.825815497266871 0.195166099561612 no 2715 0.204454380829217 3810 782427 SGTC_206 4546-0025 72.014 µM -0.826854809901759 0.194874338957215 no 2716 0.204159679793231 3921 6620745 YIL048W NEO1 SGTC_1713 st033146 12.748 µM -0.826944971533324 0.194849040880616 no 2717 0.204134126052404 3827 674619 SGTC_2842 9000675 19.48 µM -0.827161438401828 0.194788311498534 no 2718 0.204072782475626 3918 2989072 SGTC_1760 st045453 10.4495 µM -0.828349852717336 0.194455109201721 no 2719 0.203736198749275 3935 3323419 YIL048W NEO1 SGTC_2998 9066762 71.4286 µM -0.83070908909902 0.193794665896626 no 2720 0.203068995246169 3881 4945196 SGTC_1792 st045773 43.6 µM -0.831384630824961 0.193605807244326 no 2721 0.202878189295765 3792 2919270 SGTC_2949 9072542 2.23 µM -0.831431900392963 0.19359259647255 no 2722 0.202864842073135 3956 16457352 SGTC_1562 morin hydrate 59.1 µM -0.831958670559254 0.193445413365556 no 2723 0.202716136657063 3960 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2481 5478948 45.16 µM -0.832060093941007 0.193417082833697 no 2724 0.202687512663141 3928 77792 SGTC_1693 xanthone 101.9 µM -0.833067182754527 0.193135910703543 no 2725 0.202403420292829 3926 7020 An insecticide. SGTC_3186 9110464 49.47 µM -0.834197221002597 0.192820709209608 no 2726 0.202084928442971 3874 17018021 SGTC_2011 4012611 177 µM -0.835975016987819 0.192325465229147 no 2727 0.201584478950563 3910 2049887 SGTC_756 0508-1999 28.3 µM -0.836442486409738 0.1921953706713 no 2728 0.201453009716233 3881 6753853 SGTC_863 0466-0191 129 µM -0.837262139480301 0.191967395031996 no 2729 0.201222617826448 3921 765160 YPR165W RHO1 SGTC_940 3232-1287 54.8 µM -0.83909438178823 0.191458379949719 no 2730 0.200708174278275 3797 1585493 YIL048W NEO1 SGTC_1796 st049173 110.4 µM -0.840163082594395 0.191161866488532 no 2731 0.200408477196037 3827 94134 SGTC_3214 9129694 49.47 µM -0.840557446528814 0.191052520477044 no 2732 0.200297953167279 3877 17158655 SGTC_2401 5128683 200 µM -0.840619768061164 0.191035243981939 no 2733 0.200280490350708 3877 708373 SGTC_2231 micatex 6.853 µM -0.841522196663542 0.190785184178004 no 2734 0.200027727718852 3925 20737 An antifungal of unknown mechanism. SGTC_1228 0124-0032 52.5 µM -0.843005703792919 0.190374546278332 no 2735 0.199612626909546 3969 X1228 SGTC_2428 5615643 7.78 µM -0.845030959422673 0.189814828392882 no 2736 0.199046776836738 3935 2253075 SGTC_2526 patulin 37.61 µM -0.845578129548346 0.189663781332234 no 2737 0.198894065210562 3966 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_775 4577-0580 57.3 µM -0.84575937131872 0.189613765599406 no 2738 0.198843497383941 3987 2006902 SGTC_725 1497-0963 19 µM -0.849588902720986 0.18855886052042 no 2739 0.197776841918473 3958 3549977 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.852417541172911 0.187781995650618 no 2740 0.196991193886678 3928 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_580 1123-0028 41 µM -0.8524994327118 0.187759534221855 no 2741 0.196968476867071 3966 1677248 YPR107C YTH1 SGTC_3248 9135562 49.47 µM -0.853735221291654 0.187420780347433 no 2742 0.196625857047685 3912 17650701 SGTC_877 0771-0151 33.1 µM -0.853741048007718 0.187419184025657 no 2743 0.196624242458378 3946 6166523 SGTC_2127 5253358 187.912 µM -0.854722858383568 0.187150321442213 no 2744 0.196352296454681 3839 20612 SGTC_2251 lansoprazole 556 µM -0.855324859269985 0.186985585325911 no 2745 0.196185664505871 3826 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.856723828012213 0.186603107463161 no 2746 0.195798765675731 3929 6708784 An antioxidant flavonoid SGTC_2189 6047310 154.431 µM -0.857684610744612 0.186340710395849 no 2747 0.195533319997434 3863 711535 SGTC_563 tetrahydrosecaminediol 614 µM -0.858363262920064 0.186155503160573 no 2748 0.195345953297303 3971 334274 A psychoactive constituent of the cannabis plant. SGTC_37 0566-0070 1.56 µM -0.85929136480597 0.185902404750226 no 2749 0.195089893551968 3919 1626686 SGTC_2788 5282734 71.43 µM -0.860491535452928 0.185575428279047 no 2750 0.194759073747548 3987 743706 SGTC_852 0418-0143 439 µM -0.863327233398898 0.184804284952196 no 2751 0.193978787479955 3958 5369229 SGTC_1835 st008666 49.2 µM -0.864519525001936 0.18448064730465 no 2752 0.193651279605038 3858 690455 SGTC_2897 9048598 12.99 µM -0.866999718041454 0.183808549773048 no 2753 0.192971082092154 3903 6467404 SGTC_3313 9133968 57.047 µM -0.867982591939678 0.183542627239752 no 2754 0.192701931287617 3890 1494643 SGTC_3353 9151644 39.2805 µM -0.868229713698966 0.183475804679583 no 2755 0.192634295415993 3989 4909158 SGTC_730 1436-0052 41.2 µM -0.868977734705469 0.183273629705712 no 2756 0.192429654603667 3936 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1958 st076513 41.9 µM -0.869106613103864 0.183238810512085 no 2757 0.192394409957769 3907 732122 YGL099W LSG1 SGTC_2056 5235370 200 µM -0.870584218327248 0.182839899414174 no 2758 0.191990608270252 3903 5511916 SGTC_1886 st057356 49.9 µM -0.871072100011146 0.182708304455749 no 2759 0.191857393378949 3891 24207747 SGTC_2695 st077686 51.995 µM -0.871168110829976 0.182682414692032 no 2760 0.191831184526618 3979 2876092 SGTC_2300 7976697 71.57 µM -0.872506285964675 0.182321808026791 no 2761 0.191466120218874 3839 2236109 SGTC_1301 naphtanilide LB 4.81 µM -0.874303503854798 0.181838200519813 no 2762 0.19097649584596 4004 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_163 TUB2.036 7.546 µM -0.876209889397369 0.18132609527488 no 2763 0.190457970644518 3937 15992207 YJR013W GPI14 SGTC_3154 9100113 49.47 µM -0.881289137228122 0.179966089775302 no 2764 0.189080672031151 3978 25237525 SGTC_2974 9094440 9.66 µM -0.882274282847357 0.179703053450446 no 2765 0.18881425005382 3999 25236134 SGTC_3213 9129884 49.47 µM -0.88313641427577 0.179473060519229 no 2766 0.188581285847233 3953 17190742 SGTC_601 0986-0029 62.9 µM -0.884016350668418 0.179238508612051 no 2767 0.188343693240237 3905 24747981 SGTC_2273 7815444 169.05 µM -0.885247436074119 0.178910679694698 no 2768 0.188011596549864 3887 2824616 SGTC_2795 7780010 54.55 µM -0.885462403426318 0.178853474205993 no 2769 0.187953644208869 3960 953673 SGTC_527 4476-4215 268 µM -0.886810856328941 0.178494896764243 no 2770 0.187590370850821 3929 4418754 SGTC_3323 9138564 53.9225 µM -0.887472305870158 0.178319171308126 no 2771 0.187412334976385 3976 43912313 YNL103W MET4 SGTC_2691 st077356 60.2 µM -0.887563627919429 0.178294918600888 no 2772 0.187387762925408 4027 2839272 SGTC_3265 9137266 49.47 µM -0.889516617046028 0.177776754264123 no 2773 0.186862748351497 3841 17224265 SGTC_2102 5377816 72.7585 µM -0.889789051948074 0.177704547794709 no 2774 0.186789583138394 4007 1379702 SGTC_3121 9125696 49.47 µM -0.891917572056885 0.177141039502496 no 2775 0.186218557648922 4030 1235365 SGTC_3245 9134821 49.47 µM -0.892871058629725 0.1768889782006 no 2776 0.185963113703208 3965 17014901 SGTC_2378 9074213 121.43 µM -0.893290733139411 0.176778105986703 no 2777 0.185850749640909 3923 657714 SGTC_2205 7238770 200 µM -0.898162968524743 0.175494145610608 no 2778 0.184549336352653 4026 279867 SGTC_3278 9139605 49.47 µM -0.898273705425921 0.175465032431157 no 2779 0.184519823657811 4012 7958859 SGTC_2368 9071271 200 µM -0.89844584233353 0.17541978302005 no 2780 0.184473952962831 3977 27209959 SGTC_369 0957-0393 4.5 µM -0.900701911288955 0.174827416971117 no 2781 0.183873416101571 4000 6997992 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.902047943999838 0.174474600551757 no 2782 0.183515699919401 3961 442882 SGTC_2516 gossypol 71.55 µM -0.902621743091087 0.174324336335398 no 2783 0.183363341358053 4000 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1361 1608-0041 5.61 µM -0.903600303314715 0.174068264635958 no 2784 0.183103690199788 3936 X1361 SGTC_113 0099-0221 2.5 µM -0.905745425208137 0.173507761735475 no 2785 0.182535306571397 3908 89219 SGTC_1289 0976-0073 69.1 µM -0.907574123639409 0.173030845754855 no 2786 0.182051635427144 4032 3391136 SGTC_1001 4048-4355 44.4 µM -0.907618612524363 0.173019253677206 no 2787 0.18203987858637 3959 21824233 SGTC_2004 4023728 41.89 µM -0.90773569835715 0.172988748015575 no 2788 0.18200893920542 3984 360084 YDR527W RBA50 SGTC_1170 0310-0127 64.8 µM -0.907983123313311 0.172924294939157 no 2789 0.181943569139893 4000 774975 SGTC_635 k038-0028 24.7 µM -0.908325578551866 0.172835112155521 no 2790 0.18185311615044 3985 4035102 SGTC_2473 5854593 8.94 µM -0.909002958369173 0.172658794086655 no 2791 0.181674282109057 3881 2872951 SGTC_2221 6807166 181.081 µM -0.909583264728998 0.172507834915388 no 2792 0.181521163835324 3905 674925 SGTC_1527 coumarin 137 µM -0.910278728134512 0.172327030053259 no 2793 0.181337766936909 4092 323 A hepatotoxic, DNA x-linker. SGTC_3156 9099931 49.47 µM -0.91223466174258 0.171819179662825 no 2794 0.180822600531879 3993 18111053 SGTC_2268 7933382 153.85 µM -0.915110123905641 0.171074314695323 no 2795 0.180066910348486 3993 935025 YOR257W CDC31 SGTC_2597 laccaic acid a 100 µM -0.916764726330694 0.170646641043668 no 2796 0.179632970122073 4018 5491415 A textile dye. SGTC_3016 9080866 49.47 µM -0.918097226757908 0.170302720747232 no 2797 0.179283983310126 3979 17066299 SGTC_1057 3448-5381 134 µM -0.919483909749041 0.169945287673551 no 2798 0.178921258939191 4006 5497911 SGTC_1816 st051957 91.6 µM -0.920934936145752 0.169571784670107 no 2799 0.17854219867263 3969 674121 SGTC_1269 0831-0796 3.05 µM -0.921475186732115 0.169432855535256 no 2800 0.178401195109133 4036 927758 SGTC_1607 st000305 50.6 µM -0.923394362238366 0.168939917257045 no 2801 0.177900864330835 4007 5457690 SGTC_1072 oxiconazole 14.9 nM -0.924129138107679 0.168751434943539 no 2802 0.177709542097708 3998 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1143 3454-2408 5.08 µM -0.92430315362366 0.168706816849126 no 2803 0.177664250651374 3937 X1143 SGTC_2254 7938975 95.19 µM -0.924314124513068 0.168704004134633 no 2804 0.177661395475098 4083 2969277 SGTC_2296 7971656 126.45 µM -0.924497435398376 0.168657011384428 no 2805 0.177613693062181 4051 666570 SGTC_2875 9039966 71.43 µM -0.925851051319731 0.1683102650054 no 2806 0.177261696110162 4031 6463691 SGTC_3332 9141069 11.198 µM -0.926744201021651 0.168081724325719 no 2807 0.177029681110775 3933 17332883 SGTC_558 k064-0027 21.3 µM -0.931604288612414 0.166841618594117 no 2808 0.17577053298174 4025 5088526 SGTC_2126 5251174 33.877 µM -0.931756803955435 0.166802798356619 no 2809 0.175731111442527 4028 790722 SGTC_2878 9043973 25.97 µM -0.934956314723597 0.165989759858281 no 2810 0.174905406604626 4083 6465167 SGTC_172 1112-0046 2.638 µM -0.935493265187975 0.16585356493207 no 2811 0.174767076262718 3990 2802135 YIL048W NEO1 SGTC_1897 st060201 15 µM -0.936875246617864 0.165503364228105 no 2812 0.174411366706846 4057 611878 SGTC_3320 9137005 35.139 µM -0.937620888212348 0.165314613881324 no 2813 0.174219636436483 4028 4908713 SGTC_1991 st073000 8.92 µM -0.946676489212049 0.163033419979069 no 2814 0.171901827145749 4103 4301969 YIL048W NEO1 SGTC_3161 9100388 49.47 µM -0.94782575338502 0.162745379363719 no 2815 0.171609083796298 4086 25236368 SGTC_1636 st007707 68.9 µM -0.949271092528921 0.162383603512359 no 2816 0.171241375968218 4075 403051 SGTC_2681 menadione 3.18 µM -0.949293385386574 0.16237802759712 no 2817 0.171235708404054 4052 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2619 obliquin 87.91 µM -0.950513518108463 0.162073036667154 no 2818 0.170925694205828 3967 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2450 5739737 12.93 µM -0.950545188716992 0.16206512508265 no 2819 0.170917652047339 4074 2262825 SGTC_1210 3013-0140 750 nM -0.950564856789949 0.162060211959135 no 2820 0.170912657830054 4064 905973 SGTC_1132 3456-3614 2.5 µM -0.952333347061339 0.161618836114945 no 2821 0.170463975440165 4118 3125502 SGTC_535 2293-4129 48.2 µM -0.953043323422875 0.161441862449327 no 2822 0.170284060243782 4053 396118 YIL048W NEO1 SGTC_1318 1280-3875 124 µM -0.955570309855601 0.160812993880007 no 2823 0.169644683776647 4050 373245 SGTC_2046 4110841 106 µM -0.957478073173629 0.160339286792215 no 2824 0.169163004261495 4042 44119630 YMR134W ERG29 SGTC_359 0081-0058 15.9 µM -0.961857127172912 0.159255398462206 no 2825 0.168060688536625 4141 3494159 SGTC_661 1304-0007 33.6 µM -0.961909964705907 0.159242349665574 no 2826 0.168047416314632 4046 3117130 SGTC_684 1140-0066 328 µM -0.96422058078683 0.158672403065995 no 2827 0.167467674092273 4119 6813534 SGTC_1939 st074455 53.6 µM -0.96425234703871 0.158664576796016 no 2828 0.167459712810989 4082 1644229 SGTC_555 4296-0685 37 µM -0.965703941181217 0.158307216742202 no 2829 0.167096173407414 3997 2908540 YHR072W ERG7 SGTC_2990 9074105 71.4286 µM -0.967054904489614 0.15797510527116 no 2830 0.166758293663117 3960 6502001 SGTC_604 1000-0114 314 µM -0.9684070996073 0.157643149380698 no 2831 0.166420547579994 4054 1572745 SGTC_2876 9059903 25.97 µM -0.968506519116385 0.157618760579199 no 2832 0.166395732400711 4004 6916095 SGTC_2750 bromebric acid 70.15 µM -0.968762452577124 0.157555988428195 no 2833 0.166331862221416 4113 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2321 7390090 138.78 µM -0.969277875080995 0.157429621916815 no 2834 0.166203282593186 4079 649046 SGTC_3251 9135047 49.47 µM -0.969508090042668 0.157373201473889 no 2835 0.166145872876012 4064 17682963 SGTC_458 nppb 133 µM -0.970978521808563 0.157013145748081 no 2836 0.165779487111361 4073 4549 A chloride channel blocker. SGTC_1641 st009299 47.1 µM -0.973755351509082 0.156334679282463 no 2837 0.165089013413992 3962 4046054 SGTC_1881 5652484 16 µM -0.974613227962247 0.156125464213926 no 2838 0.164876074774822 4035 2255129 SGTC_1116 jasmonic acid  1.58368 µM -0.975611410893601 0.155882264152059 no 2839 0.164628533829377 4124 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_994 3910-0338 138 µM -0.977573968662239 0.155404829743167 no 2840 0.164142538650435 4149 3479481 SGTC_1356 1502-0781 85.8 µM -0.980713517516238 0.154643075416235 no 2841 0.16336701800331 4048 567702 SGTC_2326 6164455 177.58 µM -0.981840728964203 0.154370181113106 no 2842 0.1630891597273 4047 2888790 SGTC_1033 k072-0102 21.3 µM -0.983158515472364 0.154051553139342 no 2843 0.162764714272922 4052 5965931 SGTC_3145 9085516 49.47 µM -0.985128946452381 0.153575934335248 no 2844 0.162280368242821 4123 25236195 SGTC_2988 9073640 71.4286 µM -0.987573100972 0.152987321629153 no 2845 0.161680882716405 4141 9102229 SGTC_2973 9094665 17.96 µM -0.98922379944823 0.152590639952976 no 2846 0.161276828320496 4116 25237061 YIL048W NEO1 SGTC_1906 st060206 94.7 µM -0.991766877449015 0.151980845946518 no 2847 0.160655629376304 4108 5133468 SGTC_2541 muurolladie-3-one 83.07 µM -0.992914234115139 0.151706256729145 no 2848 0.160375876228013 4103 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_304 1310-0298 97 µM -0.994230271163582 0.151391704591475 no 2849 0.160055386950897 3915 1550234 SGTC_2452 5863136 48.41 µM -0.994292160375787 0.151376922848308 no 2850 0.160040325633865 4043 2184096 SGTC_2806 7952793 58.44 µM -0.995096571123219 0.151184883089627 no 2851 0.159844649083172 4157 2972490 SGTC_2373 9071805 200 µM -0.995872075399988 0.150999897781196 no 2852 0.159656152393541 4084 10149009 SGTC_2337 9009472 200 µM -0.996324010911552 0.150892164611367 no 2853 0.159546370533419 4041 5742383 SGTC_1483 3453-0561 55.9 µM -0.996829126539876 0.150771814835988 no 2854 0.159423728917806 4088 4546991 SGTC_1660 st012960 28.1 µM -0.99969885353195 0.150089281635338 no 2855 0.158728133532582 4087 24207266 SGTC_275 trichlorophene 5.69 µM -1.00014689775353 0.149982905410644 no 2856 0.158619711586342 4133 62616 SGTC_2247 cerulenin 830 nM -1.0019466055727 0.149556119133661 no 2857 0.158184690816986 4147 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2653 dihydrofissinolide 100 µM -1.00355996450114 0.1491742135816 no 2858 0.157795380028125 4131 6857746 SGTC_2120 5538279 151.968 µM -1.004304376806 0.148998220123389 no 2859 0.15761596232581 4059 2058197 SGTC_1817 st052116 64.4 µM -1.00439781307327 0.148976139785702 no 2860 0.157593451857117 4115 4361398 SGTC_3144 9087057 49.47 µM -1.00698530834972 0.148365545806332 no 2861 0.156970917185365 3940 17249618 SGTC_3018 9082602 49.47 µM -1.0074243849353 0.14826209940812 no 2862 0.156865438962016 4059 17332089 SGTC_884 0851-0618 334 µM -1.00786901317842 0.148157394223058 no 2863 0.156758674613419 4120 9642473 SGTC_788 1182-0090 188 µM -1.01040680695226 0.147560718304888 no 2864 0.156150213989324 4142 5715185 SGTC_3168 9103419 49.47 µM -1.01069759510195 0.147492452295217 no 2865 0.156080594218855 4097 16649256 SGTC_1490 4089-0339 670 nM -1.0123906502643 0.147095407550083 no 2866 0.155675653502222 4047 742542 SGTC_2563 tomatine 8.54 µM -1.01249924019048 0.147069966196324 no 2867 0.155649704900472 4009 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1263 0774-1208 64.8 µM -1.02077474481624 0.145139790306122 no 2868 0.15368058621153 4168 906585 SGTC_399 oxolinic acid 75 µM -1.02131572832445 0.145014207885926 no 2869 0.153552438502648 4085 4628 A DNA gyrase inhibitor. SGTC_2420 aureobasidin a 50 nM -1.02536371557933 0.144076840928043 no 2870 0.152595801063469 4245 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1500 4488-1866 171 µM -1.02629659751067 0.143861399925429 no 2871 0.15237590030226 4178 2900003 SGTC_515 4092-1064 102 µM -1.02652163720746 0.143809461509561 no 2872 0.152322885007854 4157 717353 SGTC_329 k048-0121 21.3 µM -1.02779918179145 0.143514848241994 no 2873 0.152022150621444 4150 6832902 SGTC_2358 9037157 4 µM -1.02941482433921 0.143142850357902 no 2874 0.151642392962883 4122 2388925 SGTC_2165 5727197 32.143 µM -1.03951854016945 0.140831274033326 no 2875 0.149281820008457 4297 1361712 SGTC_3079 9117512 49.47 µM -1.03981615236207 0.140763571082315 no 2876 0.149212661669469 4176 7185044 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.04316231339651 0.140003882494489 no 2877 0.148436562270802 4123 688662 SGTC_445 e6 berbamine 66 µM -1.04343002194963 0.139943224439901 no 2878 0.148374587528443 4159 6610268 A calcium/calmodulin antagonist. SGTC_2437 5741531 144.16 µM -1.04394547411063 0.139826482342894 no 2879 0.148255308692893 4168 2262990 SGTC_597 k018-0003 82.8 µM -1.04496226178549 0.139596389488295 no 2880 0.148020205831163 4203 6786234 SGTC_1563 conessine 56.1 µM -1.04571558131668 0.139426084006693 no 2881 0.147846183397405 4216 441082 An anti-amoebic, histamine inhibitor. SGTC_1145 3546-0597 10.2 µM -1.05176067484898 0.138064567532547 no 2882 0.146454682781225 4116 875334 SGTC_1374 2889-5571 141 µM -1.05286220751399 0.137817452927153 no 2883 0.146202074597227 4183 2853281 SGTC_1233 0325-0408 14.2 µM -1.05315597030676 0.137751602046498 no 2884 0.14613475711215 4186 12874 SGTC_1499 4480-0877 67.3 µM -1.05372074786985 0.13762505988764 no 2885 0.146005393486814 4086 2861909 SGTC_27 0485-0001 32.618 µM -1.05377177536612 0.137613630747974 no 2886 0.145993709310147 4082 2054479 SGTC_3133 9127736 49.47 µM -1.05516062402945 0.137302805155843 no 2887 0.145675934694469 4170 27243420 SGTC_1943 st076331 65.2 µM -1.05541931735367 0.137244962367459 no 2888 0.145616795949681 4156 24208415 SGTC_2019 4016004 108 µM -1.05790777334551 0.136689403682515 no 2889 0.145048745470622 4180 45595336 SGTC_1189 1431-2119 7.28 µM -1.05930426931821 0.136378304319145 no 2890 0.144730615623434 4146 3107275 SGTC_2182 6325192 200 µM -1.06416973459707 0.135298203403037 no 2891 0.143625907442163 4118 736248 SGTC_86 0417-1630 471.922 µM -1.06923065927497 0.134180949175705 no 2892 0.142482873399349 4166 3634867 SGTC_1322 1348-1070 12 µM -1.0701635628045 0.133975694319544 no 2893 0.142272846142946 4159 6758089 SGTC_692 k241-0027 77.8 µM -1.07052440741977 0.1338963601803 no 2894 0.142191664367518 4221 3600480 SGTC_1353 1498-1206 8.11 µM -1.070669430085 0.133864485059616 no 2895 0.142159046421514 4201 6756808 SGTC_2037 5169046 200 µM -1.07291803841364 0.133370921599079 no 2896 0.141653945942932 4229 5718022 SGTC_35 0133-0054 64.071 µM -1.07356330177206 0.133229519490855 no 2897 0.141509226463711 4182 99677 SGTC_2382 9035899 200 µM -1.07726618399083 0.132420069844879 no 2898 0.140680682503845 4157 6462679 SGTC_733 4069-0007 56.1 µM -1.07739970462772 0.132390945690912 no 2899 0.140650868017934 4172 5717425 YNL287W SEC21 SGTC_1840 st055363 71 µM -1.07866488851012 0.132115196878763 no 2900 0.140368571665705 4206 676033 SGTC_1682 st012968 530 nM -1.07887242063735 0.132070002761336 no 2901 0.140322302456135 4191 24207270 SGTC_429 1112-0049 25.5 µM -1.08119072107869 0.131565872868975 no 2902 0.139806142332297 4144 2836170 SGTC_1060 3448-7350 82 µM -1.08206336989197 0.131376454086315 no 2903 0.139612185399487 4137 570178 SGTC_593 1203-0218 61.7 µM -1.08319845847112 0.131130351508241 no 2904 0.139360171914473 4203 3666956 SGTC_968 1309-0633 340 µM -1.08541428598796 0.130650848149364 no 2905 0.138869103940641 4216 3761976 SGTC_1012 4112-3522 18 µM -1.08784938280345 0.130125294764722 no 2906 0.138330802374825 4215 3112398 SGTC_53 0973-0023 39.979 µM -1.09033260323626 0.129590863670802 no 2907 0.137783329193041 4055 674768 SGTC_912 3474-0017 2.18 µM -1.09139884687863 0.12936185721435 no 2908 0.137548709800037 4222 3360550 SGTC_1797 st048695 56.8 µM -1.0940537206581 0.128792865810309 no 2909 0.136965709005017 4155 592262 YIL048W NEO1 SGTC_3223 9129970 49.47 µM -1.10280516592127 0.126929564182052 no 2910 0.135055892122121 4216 17248386 SGTC_843 0310-0051 143 µM -1.1053361428116 0.126394200383074 no 2911 0.134506981212831 4228 2065037 SGTC_3239 9133757 49.47 µM -1.10615253369761 0.12622184972816 no 2912 0.134330251862273 4226 17036923 SGTC_2989 9073649 71.4286 µM -1.10809819499949 0.125811756090213 no 2913 0.133909705211086 4152 21367202 SGTC_1323 1348-1351 11.2 µM -1.10813217730353 0.125804601791735 no 2914 0.133902368125141 4155 6989654 SGTC_1578 josamycin 24.2 µM -1.10882520301489 0.12565876090755 no 2915 0.133752797892191 4207 5282165 A P450 substrate. SGTC_32 0928-0142 34.1 µM -1.10969382706012 0.125476133601177 no 2916 0.133565491911381 4186 2244242 SGTC_571 k831-0106 44.2 µM -1.11090740371343 0.125221290692039 no 2917 0.133304104159796 4066 4783639 SGTC_971 1315-0384 26.7 µM -1.11454527743725 0.124459528022626 no 2918 0.13252266578497 4245 6769120 SGTC_2243 6634756 200 µM -1.1183671134055 0.123662740494674 no 2919 0.131705116977143 4272 885676 SGTC_1277 0873-0036 22 µM -1.11867015600654 0.123599714472879 no 2920 0.131640440802331 4277 5965735 SGTC_1715 st032160 10.2275 µM -1.11928268022656 0.123472391951681 no 2921 0.131509781153321 4153 5289825 SGTC_1040 k898-0338 155 µM -1.1197085566057 0.123383921198222 no 2922 0.131418988773153 4215 20969351 SGTC_1975 st070967 30.8 µM -1.12179929378978 0.122950239608805 no 2923 0.130973893286705 4205 261391 SGTC_130 0136-0219 337.655 µM -1.12270754176677 0.122762175116375 no 2924 0.130780861947972 4042 234244 SGTC_1283 0922-0125 16.4 µM -1.12552928626396 0.122179183843559 no 2925 0.130182407124882 4218 3360884 SGTC_216 k038-0035 28.382 µM -1.12585136232109 0.122112764580838 no 2926 0.130114219722309 4139 4444231 YPR107C YTH1 SGTC_2355 9061122 103.12 µM -1.1295200926348 0.121357979504444 no 2927 0.129339249204729 4236 5302957 SGTC_1044 1222-0021 1.78 µM -1.13126904026086 0.120999317325214 no 2928 0.128970935477815 4181 4306703 SGTC_2844 9010103 25.97 µM -1.13180848464654 0.120888842415204 no 2929 0.128857479922265 4244 2480525 SGTC_1932 st074806 40.9 µM -1.13445842137105 0.120347182409988 no 2930 0.128301152572329 4300 17251235 SGTC_195 4234-0266 16.654 µM -1.13517114364458 0.120201790685478 no 2931 0.12815180877631 4231 2303354 SGTC_372 0155-0182 15.9 µM -1.13681104758136 0.11986772871412 no 2932 0.127808641999535 4123 771486 SGTC_1783 st039459 87.517 µM -1.13724613127712 0.119779208544125 no 2933 0.1277177035518 4336 729761 SGTC_997 3996-0078 137 µM -1.13779318635453 0.11966797260959 no 2934 0.127603425392458 4274 735687 SGTC_1333 1482-0047 286 µM -1.13851566410778 0.119521178621641 no 2935 0.12745261093035 4242 3811116 SGTC_2617 dihydrotanshinone i 20.83 µM -1.14025724724821 0.119167843764515 no 2936 0.127089571814305 4197 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1111 tnp00062 510.699 nM -1.14104686722987 0.119007887720632 no 2937 0.126925210077566 4272 676306 SGTC_3033 9090887 49.47 µM -1.14225366708004 0.118763715121931 no 2938 0.126674297093479 4240 19325384 SGTC_310 1273-0058 1.06 µM -1.14370994022451 0.118469537897041 no 2939 0.126371974812926 4064 2734232 SGTC_393 acivicin 6.25 µM -1.14465446979078 0.118279011968634 no 2940 0.126176159485272 4096 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2654 protoveratrine a 100 µM -1.14607778664891 0.117992316753556 no 2941 0.125881483926103 4231 5702278 A heart drug and vasodilator. SGTC_1794 st048918 76.9 µM -1.14897241405285 0.117410776341235 no 2942 0.125283677901441 4166 672303 SGTC_225 nsc-122657 1.016 µM -1.14904603777888 0.117396011601098 no 2943 0.125268498828417 4242 275685 SGTC_1395 3486-0190 4.35 µM -1.15189557609708 0.116825565923075 no 2944 0.124681993176937 4232 6748079 SGTC_1556 plumbagin 1.48 µM -1.1525689320172 0.116691055100995 no 2945 0.124543680633031 4165 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3170 9103054 49.47 µM -1.15284158425196 0.1166366208332 no 2946 0.124487706264592 4215 16432970 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.15820071014218 0.115570339548236 no 2947 0.123391069303331 4210 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3068 9116768 49.47 µM -1.15877009828071 0.115457459249286 no 2948 0.123274954475262 4228 41904888 SGTC_1834 st055981 52.8 µM -1.15877338340685 0.115456808205612 no 2949 0.123274284764565 4255 471719 YDL150W RPC53 SGTC_2721 ifenprodil 61.44 µM -1.15945047815097 0.115322677784515 no 2950 0.123136305633516 4254 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3206 9114350 49.47 µM -1.16220490879994 0.114778175196711 no 2951 0.122576120598446 4118 17087243 SGTC_693 4161-2696 114 µM -1.16314158982796 0.114593427227698 no 2952 0.122386030199436 4291 805759 SGTC_248 streptozotocin 5.23457 mM -1.16350438888984 0.114521926793054 no 2953 0.122312459237246 4277 5300 DNA alkylating agent. SGTC_1936 st074407 74.3 µM -1.1643238731419 0.114360539731574 no 2954 0.12214639268818 4282 809813 SGTC_2731 amoxapine 43.43 µM -1.16539147284691 0.114150532449802 no 2955 0.121930283684773 4399 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1745 st081495 74 µM -1.16827565168788 0.113584560122869 no 2956 0.121347796713086 4124 13842402 YBL026W LSM2 SGTC_1852 st056254 31.4 µM -1.17072749549302 0.113105002047339 no 2957 0.120854164768716 4206 442583 SGTC_898 1000-0849 28.3 µM -1.17090510890544 0.113070318705355 no 2958 0.120818460672984 4258 6751807 SGTC_1362 1611-0397 101 µM -1.17176406031941 0.11290269463975 no 2959 0.120645897829027 4224 27816 SGTC_1640 st009078 66.4 µM -1.17205484076929 0.112845989147325 no 2960 0.120587519537364 4239 690618 SGTC_1358 1509-0022 2.48 µM -1.1743550166671 0.112398145171511 no 2961 0.120126427567592 4295 3258434 SGTC_1098 clofazimine 15.1 µM -1.17485437036554 0.11230108905818 no 2962 0.120026491761888 4317 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_740 k014-0057 261 µM -1.17599476502683 0.112079662601015 no 2963 0.119798483992214 4259 4012779 SGTC_79 0052-0007 94.094 µM -1.17792559783333 0.111705471427123 no 2964 0.119413134541389 4266 2801472 SGTC_1147 3809-1045 12.3 µM -1.18154594172221 0.111006267212586 no 2965 0.118692957023143 4267 325925 SGTC_2317 5986382 200 µM -1.18383030823925 0.110566699098652 no 2966 0.118240121044225 4300 877883 SGTC_828 2074-0507 139 µM -1.18490847824724 0.110359666722796 no 2967 0.118026817444355 4346 X828 SGTC_2969 9091408 28.7 µM -1.1861118001816 0.110128930838649 no 2968 0.117789075543284 4231 4286311 SGTC_33 0986-0033 35.816 µM -1.18735898571863 0.109890149574004 no 2969 0.117543025297028 4244 2848082 SGTC_3276 9139060 49.47 µM -1.18754280350203 0.109854987980019 no 2970 0.117506791706159 4379 4870619 SGTC_935 2996-0153 430 µM -1.18894243604944 0.109587523985596 no 2971 0.11723115981338 4272 23738523 SGTC_3046 9092212 49.47 µM -1.18905400337326 0.109566224070071 no 2972 0.117209208405153 4351 25236637 SGTC_1702 st027038 51 µM -1.18916899915863 0.109544272719931 no 2973 0.117186585478076 4301 5521182 SGTC_1611 st001856 99.4 µM -1.1893123316113 0.109516916653017 no 2974 0.117158392256964 4241 647478 SGTC_2447 5741742 33.78 µM -1.19067899560814 0.109256325015671 no 2975 0.11688981337189 4321 1776504 SGTC_3327 9140648 26.9345 µM -1.19327767135024 0.108762046370036 no 2976 0.116380322123448 4308 8029710 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.19389763297951 0.108644365091929 no 2977 0.116259006777567 4257 364106 SGTC_1254 0550-0035 264 µM -1.19471911521951 0.108488572230698 no 2978 0.116098395736048 4291 15121435 SGTC_1524 corynanthine 62.1 µM -1.20081688568137 0.107337161854993 no 2979 0.114911120154573 4381 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2433 5607874 27.82 µM -1.20225346355667 0.107067187187099 no 2980 0.114632670517735 4246 2252428 SGTC_2077 5212015 200 µM -1.20405971479938 0.10672843562058 no 2981 0.114283249524884 4170 780900 SGTC_1059 3448-6867 171 µM -1.20851415933095 0.105896338688372 no 2982 0.113424776375487 4247 3934407 SGTC_1022 4477-0945 21.3 µM -1.2090093974824 0.105804117870932 no 2983 0.113329617514688 4241 4648966 SGTC_1572 epiandrosterone 68.9 µM -1.20971314227525 0.105673169850915 no 2984 0.113194492563317 4214 441302 A steroid. SGTC_1250 0485-0349 40.2 µM -1.21099711803688 0.105434558414542 no 2985 0.112948254615735 4314 6842794 YDL195W SEC31 SGTC_3058 9093861 49.47 µM -1.21164213833812 0.105314836327207 no 2986 0.112824698473573 4312 17217477 SGTC_2585 alliin 100 µM -1.21215243842958 0.105220189338134 no 2987 0.112727016901833 4358 87310 A garlic compound which reacts with lipids. SGTC_3075 9116269 49.47 µM -1.21548651564265 0.104603321820082 no 2988 0.112090294324093 4323 17015205 YNL244C SUI1 SGTC_2469 5655019 90.81 µM -1.21582357080852 0.104541106328495 no 2989 0.112026068877862 4354 2788239 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.21737100818917 0.104255815899059 no 2990 0.111731544266031 4287 140250 A respiratory chain inhibitor. SGTC_1316 1272-0050 65.9 µM -1.21741128606624 0.104248397685435 no 2991 0.111723885558604 4255 7340392 SGTC_3279 9140807 49.47 µM -1.21744568643096 0.104242062270768 no 2992 0.111717344738381 4337 45595718 SGTC_3085 9117376 49.47 µM -1.21808392779915 0.104124569839465 no 2993 0.111596040416608 4382 16480349 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.22002164652088 0.103768447788593 no 2994 0.111228334552083 4300 5377381 SGTC_914 3820-6779 408 µM -1.22262242609183 0.103291855618519 no 2995 0.110736169387159 4251 2893481 SGTC_1690 st023502 41.2 µM -1.22405954609208 0.103029186453768 no 2996 0.110464882654543 4312 24207482 SGTC_2803 7707263 71.43 µM -1.22588382079109 0.102696454509946 no 2997 0.110121199048107 4283 2199229 SGTC_3289 9119912 71.43 µM -1.23082817990041 0.101798574435095 no 2998 0.109193566785776 4333 17014829 SGTC_3295 9122362 53.5725 µM -1.23393847676445 0.101236690209591 no 2999 0.108612915257778 4313 4730473 SGTC_63 0099-0242 26.702 µM -1.23482852553063 0.101076316940395 no 3000 0.108447164297131 4330 3898502 YLR359W ADE13 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.23600396905168 0.100864803731628 no 3001 0.108228544165462 4376 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_400 oxethazaine 37.5 µM -1.23737099458132 0.100619222748213 no 3002 0.10797469098851 4329 4621 A local anesthetic. SGTC_2096 5468907 200 µM -1.23815891285915 0.100477874491559 no 3003 0.107828571483206 4311 759785 SGTC_1458 k015-0034 6.33 µM -1.23949791213623 0.100237997700579 no 3004 0.10758058074619 4344 3598957 SGTC_1501 4491-0275 38.4 µM -1.24213773847039 0.0997663074640324 no 3005 0.10709287336507 4303 5104718 SGTC_1727 st034309 9.9045 µM -1.2429656081315 0.0996187163363765 no 3006 0.106940253562266 4382 870305 SGTC_1366 1683-0113 21.9 µM -1.24609888438884 0.0990615660574523 no 3007 0.106364047180037 4313 708623 SGTC_2044 5102272 200 µM -1.24745388595366 0.0988213307564012 no 3008 0.106115559387417 4318 592666 SGTC_3006 9075424 71.4286 µM -1.25170103678899 0.0980710939080448 no 3009 0.10533941108118 4287 7465181 SGTC_2361 9034121 116 µM -1.25370404621149 0.0977187245306987 no 3010 0.104974798352472 4346 6496917 SGTC_1803 st050068 52.4 µM -1.25501019374204 0.097489447616942 no 3011 0.104737529740672 4375 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_786 4544-0069 423 µM -1.25587427744579 0.0973379861598531 no 3012 0.104580777962301 4317 748821 YLR208W SEC13 SGTC_2318 6029776 164 µM -1.25668209791892 0.0971965430446808 no 3013 0.104434386557826 4361 818325 SGTC_2164 5685496 200 µM -1.2583168155777 0.0969107781585565 no 3014 0.10413860107473 4252 759046 SGTC_132 0417-1715 25.805 µM -1.25929873297248 0.0967394260451422 no 3015 0.103961225359205 4322 6769098 SGTC_929 2805-0021 398 µM -1.25995346867344 0.0966252933586428 no 3016 0.103843074276836 4390 3098024 SGTC_1305 1181-0477 144 µM -1.26072573898275 0.0964907993643208 no 3017 0.103703838580634 4395 6252086 SGTC_1895 st058434 18.3 µM -1.26209914217857 0.0962519555446435 no 3018 0.103456556957005 4344 5393175 SGTC_3224 9130643 49.47 µM -1.26387774866878 0.0959432903776927 no 3019 0.103136954754721 4394 17644395 SGTC_982 1491-0518 27.5 µM -1.26473079765908 0.0957955080349638 no 3020 0.102983922943515 4271 3091256 SGTC_5 0352-0601 109.883 µM -1.26768125142789 0.0952856621306873 no 3021 0.102455901394841 4238 762456 SGTC_1020 4335-0961 93.3 µM -1.26799192408995 0.0952320935865773 no 3022 0.10240041729519 4297 669075 SGTC_1014 4130-3005 69.3 µM -1.27371014592711 0.0942500712142779 no 3023 0.101383079696318 4361 743608 SGTC_1212 0520-0165 585 µM -1.27454479262564 0.0941073596044211 no 3024 0.101235204359402 4450 5403258 SGTC_575 k072-0246 11.9 µM -1.27766793719123 0.0935747647937978 no 3025 0.100683267507086 4424 6796779 SGTC_1347 1493-0251 600 nM -1.2778730890322 0.093539857991303 no 3026 0.100647089075873 4387 3986378 SGTC_1590 st077108 57.8 µM -1.28160583535146 0.0929064056027956 no 3027 0.0999904760706223 4369 5489485 SGTC_309 k408-0051 1.48 µM -1.28164670679235 0.0928994872576552 no 3028 0.0999833038876326 4258 3640463 SGTC_327 1273-0057 3.96 µM -1.28519628553179 0.0923000989197113 no 3029 0.0993618506614099 4252 3108138 SGTC_513 4245-1575 41.7 µM -1.28695831475993 0.0920036246563606 no 3030 0.0990544089432537 4197 719745 SGTC_1164 k060-0068 93.7 µM -1.29152774642307 0.0912380708864873 no 3031 0.0982603701163032 4366 5963676 SGTC_2244 6635614 200 µM -1.2918877263554 0.0911779618499776 no 3032 0.098198014401881 4289 836499 SGTC_1133 3473-0247 50 µM -1.29307082913163 0.0909806155628464 no 3033 0.0979932815634498 4328 711311 SGTC_2591 skatole 100 µM -1.29438214903468 0.0907622525646052 no 3034 0.0977667267609463 4374 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2924 9010168 62.78 µM -1.29442941804757 0.0907543885249599 no 3035 0.0977585673395203 4391 2993929 SGTC_2058 5236698 133 µM -1.29647870169818 0.0904139397695877 no 3036 0.0974053065561802 4319 766665 SGTC_1108 betulinic acid 729.144 nM -1.29810208571285 0.0901449198592004 no 3037 0.0971261288534419 4348 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1416 3966-0321 25.3 µM -1.29829880427421 0.0901123609796131 no 3038 0.0970923385677726 4396 582530 YLR208W SEC13 SGTC_2319 6033012 152.6 µM -1.30257743416703 0.0894063650686343 no 3039 0.0963595329629398 4316 847246 SGTC_2331 7980721 200 µM -1.30258217100396 0.0894055857527789 no 3040 0.0963587239383809 4321 2981221 SGTC_3097 9117246 49.47 µM -1.30330633170323 0.0892865045102137 no 3041 0.0962351001549564 4391 16423892 SGTC_3149 9097855 49.47 µM -1.30371251650425 0.0892197630149497 no 3042 0.0961658101066216 4370 25236625 YMR079W SEC14 SGTC_1351 1496-0003 46.5 µM -1.30374811054171 0.0892139162167954 no 3043 0.0961597399570953 4383 3891978 SGTC_2962 9082311 13.18 µM -1.30396616769046 0.0891781036280245 no 3044 0.0961225589924496 4336 16459453 SGTC_182 3448-4371 550.524 µM -1.30570957571655 0.0888921598261272 no 3045 0.0958256701703596 4258 3491403 SGTC_84 0443-0269 128.823 µM -1.30584855990883 0.0888693938462007 no 3046 0.0958020313052902 4293 6150058 SGTC_1118 chelidonine 707.474 nM -1.30758765744753 0.0885848919567015 no 3047 0.0955066027446893 4352 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_29 0299-0004 12.984 µM -1.30964947085131 0.0882484760708487 no 3048 0.0951572222791929 4269 16871 A napthoquinone isolated from Swertia calycina. SGTC_200 k038-0079 37.545 µM -1.31289724241071 0.0877204860188603 no 3049 0.0946087881163691 4358 3436683 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.31749765649495 0.0869766352399232 no 3050 0.0938359330457477 4405 23847180 SGTC_762 1165-0429 115 µM -1.31836965135595 0.0868361732842122 no 3051 0.0936899675209047 4373 5967793 SGTC_1151 3909-8316 15.3 µM -1.31893998138912 0.086744395574279 no 3052 0.0935945891900025 4414 800431 SGTC_1010 4112-3296 15.2 µM -1.32093586879179 0.0864237873500265 no 3053 0.0932613743088085 4407 704384 SGTC_1032 k061-1018 98.7 µM -1.32328443360599 0.0860476626450796 no 3054 0.0928704031807574 4434 4005393 SGTC_2491 paeonol 100 µM -1.32922262366365 0.0851021212901435 no 3055 0.0918872666203324 4333 11092 Increases levels of cortical cytochrome oxidase. SGTC_2762 leflunomide 42.06 µM -1.33409475209337 0.0843321621991732 no 3056 0.091086402759612 4368 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1731 st035964 63 µM -1.33558692253675 0.0840973982514901 no 3057 0.0908421634501156 4306 6739575 SGTC_3274 9138298 49.47 µM -1.33928166040242 0.0835182151086945 no 3058 0.0902394984052104 4369 17015756 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.34272335158649 0.0829814007304723 no 3059 0.089680785221623 4406 4174840 SGTC_2336 9001819 198.65 µM -1.34693699990429 0.0823277199284454 no 3060 0.089000261895534 4441 2989602 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.35294512082295 0.0814023718371163 no 3061 0.0880365816058155 4343 1241132 A phosphatase inhibitor. SGTC_586 0957-0265 8.15 µM -1.35322905559478 0.081358836197979 no 3062 0.0879912328078467 4276 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2676 harmalol 100 µM -1.35407890777869 0.0812286335573175 no 3063 0.0878556022946365 4365 5459187 A monoamine oxidase inhibitor SGTC_2261 9010538 184.68 µM -1.35662305618131 0.0808397939673739 no 3064 0.0874505059983449 4402 6457250 SGTC_2078 5212016 200 µM -1.36207877928412 0.0800106988572649 no 3065 0.0865865122726973 4312 1899708 SGTC_1782 st039423 80.636 µM -1.36420852700067 0.0796887959189392 no 3066 0.0862509726237248 4430 2068169 SGTC_2805 7950783 58.44 µM -1.36680656823711 0.0792974399943494 no 3067 0.0858429717368392 4410 1178958 YDL195W SEC31 SGTC_1998 st075797 76.8 µM -1.3681931967676 0.0790891616008414 no 3068 0.0856258052815963 4392 24208315 SGTC_2912 7964298 10.93 µM -1.3692680024309 0.0789280057422462 no 3069 0.0854577580756713 4414 2975850 SGTC_328 k915-0120 63.5 µM -1.36931563805867 0.0789208690393578 no 3070 0.0854503159063165 4425 6624543 SGTC_880 0833-0487 87.2 µM -1.3720441076452 0.0785129089117477 no 3071 0.0850248536573759 4410 76075 SGTC_1472 k841-0093 193 µM -1.37467012875577 0.0781217784858342 no 3072 0.0846168680375599 4518 X1472 SGTC_2851 9015922 71.43 µM -1.37714723942329 0.0777541838068292 no 3073 0.0842333650357418 4440 2996893 SGTC_989 1501-0895 10.3 µM -1.38077460356318 0.0772182664648439 no 3074 0.0836741372484788 4397 2830112 SGTC_3169 9102970 49.47 µM -1.38234414845013 0.0769872490888465 no 3075 0.0834330281840182 4500 17027839 SGTC_1354 1498-1681 81 µM -1.38525447732317 0.0765602757389989 no 3076 0.0829873340631527 4415 5754243 SGTC_456 gingerol 170 µM -1.38801142048301 0.0761574691180405 no 3077 0.0825667837657115 4461 442793 A herb. SGTC_1836 st055642 81 µM -1.38884997489538 0.0760352715789427 no 3078 0.0824391875051541 4423 8571 SGTC_859 0439-0102 54.6 µM -1.39122016303061 0.0756906854361007 no 3079 0.0820793374067337 4456 610143 SGTC_2376 9072922 81.32 µM -1.39299428433553 0.0754335369979681 no 3080 0.0818107595426366 4424 17087968 SGTC_3247 9135149 49.47 µM -1.39548683072646 0.0750733826141713 no 3081 0.0814345416569058 4482 8934436 YOR116C RPO31 SGTC_1859 st055998 20 µM -1.39691344163696 0.0748678388533794 no 3082 0.0812198009996122 4373 676301 SGTC_1813 st051246 8.6015 µM -1.39742719597006 0.0747939232061778 no 3083 0.0811425728342005 4378 5291959 SGTC_2100 5377183 190 µM -1.39782490387501 0.0747367418119472 no 3084 0.0810828269673698 4469 2844202 SGTC_594 1487-1584 10.8 µM -1.39795854598896 0.0747175345909062 no 3085 0.0810627579687775 4392 5013332 SGTC_326 k292-0812 17.5 µM -1.39958262211433 0.0744844211563726 no 3086 0.0808191704267635 4414 3579357 SGTC_2490 carminic acid 95.39 µM -1.40106847214142 0.0742716348641913 no 3087 0.0805967992323406 4400 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2757 clomiphene 4.22 µM -1.4019601495269 0.0741441621906557 no 3088 0.0804635735288434 4447 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1743 st037606 46.3785 µM -1.40200512307726 0.0741377372785445 no 3089 0.0804568584312886 4396 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2900 5328528 85.29 µM -1.40383095385967 0.0738772584102288 no 3090 0.0801845970744673 4430 795359 SGTC_1658 st012944 20 µM -1.41093839788364 0.0728699443098588 no 3091 0.0791313894299371 4285 24207260 SGTC_411 enrofloxacin 100 µM -1.41137375204134 0.0728085864740571 no 3092 0.0790672191229235 4480 71188 A bacterial gyrase inhibitor. SGTC_1027 k015-0025 8.67 µM -1.41306330743414 0.0725708389213506 no 3093 0.0788185553462973 4404 3598955 SGTC_2763 lisinopril 49.32 µM -1.41851571850411 0.0718076521181397 no 3094 0.0780201264425042 4353 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1757 st041620 31.8375 µM -1.42116963563296 0.0714384115334264 no 3095 0.0776337248821407 4478 5289815 SGTC_1376 2910-0861 41.3 µM -1.43174822787108 0.0699810744352586 no 3096 0.0761079443422861 4404 1112859 SGTC_2656 pseudo-anisatin 100 µM -1.4365950659272 0.0693210495286464 no 3097 0.0754165432073372 4516 6708809 A neurotoxin. SGTC_2942 9052777 62.25 µM -1.4414730610521 0.0686616337910249 no 3098 0.074725541295946 4469 6469503 SGTC_2108 5365811 200 µM -1.44575634053361 0.0680866109059937 no 3099 0.0741227778512205 4460 780283 SGTC_1953 st076800 12.1 µM -1.45139500146498 0.0673353074315583 no 3100 0.0733349504141688 4443 297591 SGTC_2546 rhodinyl acetate 100 µM -1.45168822051057 0.0672964144878482 no 3101 0.073294158051592 4414 6708682 SGTC_3107 9121808 49.47 µM -1.45722622349436 0.0665651038458936 no 3102 0.0725269720867419 4424 662681 SGTC_3143 9086658 49.47 µM -1.45908288235077 0.0663213079451383 no 3103 0.072271148493999 4460 25236626 SGTC_1149 3909-7961 23.3 µM -1.46010499022885 0.0661873914627774 no 3104 0.0721306106777135 4524 735261 SGTC_419 nsc-638432 893 µM -1.46807280355757 0.0651506186561988 no 3105 0.0710422240570805 4448 368090 SGTC_2532 xanthone 78.9 µM -1.47392623840627 0.0643970319085219 no 3106 0.0702507261346387 4503 7020 An insecticide. SGTC_2216 7189485 200 µM -1.47615768747832 0.064111538892339 no 3107 0.0699507827388869 4493 731273 SGTC_1006 4099-6547 255 µM -1.48011578936876 0.0636075585541656 no 3108 0.0694211742675296 4485 3146833 SGTC_3060 1327-0027 12.5 µM -1.48186510976448 0.0633858043373837 no 3109 0.0691880951609203 4396 16000455 YPR107C YTH1 SGTC_2495 cafestol 54.53 µM -1.4831984752711 0.0632171835495122 no 3110 0.0690108431024486 4474 16667697 An anti-infammatory. SGTC_1887 st057648 70.8 µM -1.48416068604246 0.0630957170551804 no 3111 0.0688831483731848 4480 688672 SGTC_1185 1319-0113 81.3 µM -1.49091023782563 0.0622487773902644 no 3112 0.0679925315586238 4546 4672763 SGTC_2290 7904846 200 µM -1.49299437937584 0.061989057076888 no 3113 0.0677193290893396 4526 2962154 SGTC_705 1124-0212 310 µM -1.49421528258709 0.0618373045203991 no 3114 0.0675596797072755 4488 9554485 SGTC_1956 st077085 54 µM -1.49561122888394 0.0616641504150971 no 3115 0.0673774976395356 4509 24208685 SGTC_1433 4060-0023 7.6 µM -1.49564992475152 0.0616593559520424 no 3116 0.0673724529360945 4512 3840627 SGTC_526 4469-0568 170 µM -1.49871257446597 0.0612808124118817 no 3117 0.0669741065892991 4457 2901964 SGTC_554 4483-2211 187 µM -1.50315008337909 0.0607355606779701 no 3118 0.0664001731041999 4543 747107 SGTC_1207 2099-0101 141 µM -1.50489159044074 0.0605226154014708 no 3119 0.0661759753638024 4495 5837381 SGTC_270 tamoxifen 5.46 µM -1.50597770047226 0.0603901057736196 no 3120 0.0660364491345798 4510 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2789 5281112 71.43 µM -1.50604297296228 0.0603821495150996 no 3121 0.0660280712238983 4498 765948 SGTC_753 1322-0200 289 µM -1.50908284910263 0.0600125178508531 no 3122 0.0656388059529178 4545 5403907 SGTC_3171 9103192 49.47 µM -1.51286218978703 0.0595554451015657 no 3123 0.065157333940172 4582 13018434 SGTC_2190 6049624 200 µM -1.51441013866899 0.05936902588882 no 3124 0.064960924706689 4398 2265554 SGTC_1381 2324-0066 62.1 µM -1.51515642453382 0.0592793144094801 no 3125 0.0648663976577823 4525 10885928 SGTC_1631 benzylvanillin 81.9 µM -1.52374784000091 0.058254174478224 no 3126 0.0637858569146641 4532 75506 SGTC_2265 7929201 200 µM -1.5256008398377 0.0580349083678332 no 3127 0.0635546514267649 4474 1265108 SGTC_2940 9060638 45.86 µM -1.52760864190248 0.0577980571327944 no 3128 0.0633048674189976 4486 4027022 SGTC_2035 5154463 94.595 µM -1.5330306417669 0.0571622449475128 no 3129 0.0626341526169273 4529 2769623 SGTC_2356 9061756 188.97 µM -1.54760106570977 0.0554808990714495 no 3130 0.0608591873406053 4553 20104043 SGTC_1282 0886-0010 32.4 µM -1.54862815606447 0.0553638674771104 no 3131 0.060735566729297 4538 2836211 YNL267W PIK1 SGTC_152 4469-0003 551.229 µM -1.54967787910027 0.0552444585253976 no 3132 0.0606094250608543 4492 697280 SGTC_1182 1222-0449 220 µM -1.56215608800229 0.0538405560680145 no 3133 0.0591256112235939 4529 658318 SGTC_983 1491-0821 12.2 µM -1.56624671097505 0.0533865255567221 no 3134 0.0586454355517714 4528 46495113 SGTC_2881 9058953 51.95 µM -1.56832418503493 0.0531571051154422 no 3135 0.058402747245108 4500 17122249 SGTC_1558 st069300 45.6 µM -1.56951699910311 0.0530257334563478 no 3136 0.0582637608294937 4492 24208000 SGTC_2558 carylophyllene oxide 100 µM -1.57433075824994 0.052498179981823 no 3137 0.0577055012044092 4627 6708694 An oxygenated terpenoid and antifungal agent. SGTC_438 sphingosine 6.67 µM -1.57756055854212 0.0521465585540458 no 3138 0.0573332997179928 4473 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_363 0455-0021 3.06 µM -1.58230565188082 0.0516333662542672 no 3139 0.0567899055612469 4479 4597466 SGTC_1281 0884-0031 11.8 µM -1.58421686847476 0.0514278017152212 no 3140 0.0565721879491852 4543 1548255 SGTC_821 1114-0266 29.2 µM -1.58550933648164 0.0512891571602514 no 3141 0.0564253286619866 4558 3123235 SGTC_936 3005-4620 401 µM -1.58995561654586 0.0508144692375597 no 3142 0.0559224048979579 4547 777207 SGTC_209 4077-0173 175.592 µM -1.59191199208855 0.0506067164930347 no 3143 0.0557022403188538 4513 15993494 SGTC_1710 st031758 61.5 µM -1.59450079240998 0.0503328454868246 no 3144 0.0554119566993816 4569 5394341 SGTC_2493 resveratrol 26.09 µM -1.59515953445951 0.0502633455538539 no 3145 0.0553382825560891 4504 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2749 bexarotene 57.39 µM -1.59541065419496 0.0502368715581271 no 3146 0.0553102175332044 4540 82146 An retinoic acid receptor inhibitor. SGTC_2122 5258151 111.688 µM -1.59616393748875 0.0501575242440402 no 3147 0.0552260983758332 4554 2173356 SGTC_3087 9117406 49.47 µM -1.59683997346545 0.0500863988941951 no 3148 0.0551506914938405 4536 42546093 SGTC_1811 st050069 61.5 µM -1.5972705009558 0.0500411452764511 no 3149 0.0551027117008912 4551 3877702 SGTC_1752 st044819 83.042 µM -1.59833580903219 0.0499293087205959 no 3150 0.0549841310426733 4495 441209 YML126C ERG13 SGTC_2684 capsaicin 100 µM -1.59910854899659 0.0498483109126162 no 3151 0.0548982427270495 4575 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_625 k213-0058 121 µM -1.59916290197971 0.0498426176364628 no 3152 0.0548922055083119 4607 3655420 SGTC_3336 9143619 71.43 µM -1.60678631580062 0.0490492173491475 no 3153 0.0540506255521159 4549 45595730 SGTC_2141 5621638 7.665 µM -1.61152927150419 0.0485607108362166 no 3154 0.0535322062695645 4553 2856238 SGTC_787 4152-0075 138 µM -1.61374939632888 0.0483333868632949 no 3155 0.0532908974105891 4573 9566539 SGTC_2370 9071495 200 µM -1.6150666347332 0.0481989144708948 no 3156 0.0531481327322524 4564 21791103 SGTC_1325 1431-0015 227 µM -1.62023149515049 0.0476745368463581 no 3157 0.0525912791306425 4554 1103340 SGTC_2588 indole-3-carbinol 100 µM -1.62495288880347 0.0471991901054761 no 3158 0.0520862987526323 4527 3712 Induces cell cycle arrest. SGTC_808 0711-0032 135 µM -1.62642570805211 0.0470516875175007 no 3159 0.0519295628144345 4531 4252555 SGTC_1494 4358-1428 177 µM -1.62848475116101 0.0468460945038169 no 3160 0.05171106999752 4563 1564571 SGTC_690 glyoxal 20.3 µM -1.62866889808046 0.0468277428095201 no 3161 0.0516915651281325 4358 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2930 9013230 14.89 µM -1.63144686759215 0.0465515952786053 no 3162 0.0513980312099003 4532 2995857 SGTC_1420 4'-methoxyflavone 42 µM -1.6413787781549 0.0455749746254329 no 3163 0.0503594061692875 4569 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3210 9128157 49.47 µM -1.64344599741294 0.045373787517901 no 3164 0.0501453449227539 4510 17590849 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.64378222242909 0.0453411328752793 no 3165 0.0501105973948376 4586 5357218 A potent inhibitor of glutathione S-transferases. SGTC_509 pifithrin 175 µM -1.64425159003262 0.0452955788557765 no 3166 0.0500621222129801 4650 4817 A p53 inhibitor. SGTC_2285 7945142 200 µM -1.6506381639949 0.0446793874727448 no 3167 0.0494062405925939 4572 2970608 SGTC_2719 novobiocin 32.65 µM -1.65249365958185 0.0445016361352574 no 3168 0.04921697830155 4589 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1293 1000-1278 195 µM -1.6551146899314 0.0442515199526877 no 3169 0.0489506178102178 4578 678847 SGTC_48 0382-0018 55 µM -1.65816400770165 0.0439619609811722 no 3170 0.0486421836691782 4590 762596 SGTC_1766 st045414 44.774 µM -1.66319199235596 0.0434878493058905 no 3171 0.0481370050206345 4570 253960 SGTC_1510 1123-0200 71.5 µM -1.67074739389306 0.0427831853166201 no 3172 0.0473857916396471 4575 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_50 0929-0078 56.389 µM -1.67393563331231 0.0424886124643401 no 3173 0.0470716250781345 4424 1377751 SGTC_1957 st077035 62.4 µM -1.67659704424314 0.0422439732156658 no 3174 0.0468106525793049 4604 705593 SGTC_323 4013-0906 34.3 µM -1.68223330551889 0.0417296454522227 no 3175 0.046261804082184 4603 2910086 SGTC_224 benfluorex 43.875 µM -1.68399839606994 0.0415696218693996 no 3176 0.0460909893566181 4587 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2306 7482397 179.52 µM -1.68511160449051 0.041468953997394 no 3177 0.0459835205772272 4561 891448 SGTC_2069 5228469 200 µM -1.69172336683997 0.0408751137723555 no 3178 0.0453493654840894 4589 2835210 SGTC_51 1013-0126 23.419 µM -1.6966483690322 0.0404372696081391 no 3179 0.0448815796937653 4568 1627850 SGTC_1973 st070275 50.2 µM -1.69669419440485 0.0404332135779107 no 3180 0.0448772454260443 4577 17118334 SGTC_1725 st036284 20.55 µM -1.69716098065634 0.0403919168738137 no 3181 0.0448331149190224 4586 707914 SGTC_2710 st078562 53.7235 µM -1.69815714737722 0.0403039002748164 no 3182 0.0447390530233842 4566 17250908 SGTC_2090 5301565 104.445 µM -1.70138913322027 0.0400194092135385 no 3183 0.0444349702442246 4604 2056344 SGTC_325 2810-4341 181 µM -1.70217342649039 0.039950619493051 no 3184 0.044361431325495 4590 774970 SGTC_999 SEC7.066 22.7 µM -1.70310899467205 0.039868687294637 no 3185 0.0442738364921861 4561 740511 YDR170C SEC7 SGTC_564 3555-0129 330 µM -1.7044507989755 0.0397514175151609 no 3186 0.0441484502233264 4515 563260 SGTC_1819 st053448 58.6 µM -1.70658345740758 0.039565606618325 no 3187 0.0439497510355392 4537 2857616 SGTC_2374 9071832 200 µM -1.71145374878667 0.0391439235362697 no 3188 0.0434986911484776 4540 17381698 SGTC_1235 benzylparaben 21.5 µM -1.71949625791246 0.0384555952128878 no 3189 0.0427620242259477 4638 7180 SGTC_1507 4075-3230 155 µM -1.72108828688509 0.0383205160810842 no 3190 0.0426174022193516 4561 659771 SGTC_1529 apigenin 74 µM -1.72889085822946 0.0376640734753429 no 3191 0.0419143152588123 4595 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1058 3448-5425 97.3 µM -1.73075578095917 0.0375085415231263 no 3192 0.041747665843473 4548 7279705 SGTC_1569 carminic acid 40.6 µM -1.73701324902615 0.0369905056505556 no 3193 0.041192416153392 4649 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2193 5925765 200 µM -1.75233865993567 0.0357464354592117 no 3194 0.0398577960698415 4638 877370 SGTC_621 3584-0052 32.1 µM -1.75553936805278 0.0354909888861529 no 3195 0.0395835464613557 4633 2273927 SGTC_1223 0764-0573 147 µM -1.75712589376453 0.0353649251333966 no 3196 0.0394481765185469 4608 1609797 SGTC_2492 derrusnin 100 µM -1.76213851065722 0.034969038649533 no 3197 0.0390229490229247 4636 1715307 Part of coumarin class of compounds. SGTC_471 1-acyl-paf 4 µM -1.76542460551393 0.0347114887469478 no 3198 0.0387462155394897 4592 16759367 SGTC_520 3584-0023 682 µM -1.76804312260676 0.0345073776678392 no 3199 0.0385268474174819 4594 1340790 SGTC_2408 sulbentine 18.36 µM -1.77164883160602 0.0342279305636149 no 3200 0.0382264341959392 4477 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1307 1187-1599 12.2 µM -1.77209966605909 0.0341931215133893 no 3201 0.0381890071905222 4638 1538471 SGTC_497 capsazepine 133 µM -1.77732529142905 0.0337917690998676 no 3202 0.0377573673753904 4571 2733484 A calcium channel blocker. SGTC_1385 3091-4834 14.1 µM -1.77782158439528 0.0337538538526099 no 3203 0.0377165811571774 4606 4072814 SGTC_603 3794-0023 45.9 µM -1.77904405111 0.0336606104586425 no 3204 0.0376162700978274 4660 3802260 SGTC_3339 9145883 14.936 µM -1.78212799193028 0.0334263251141001 no 3205 0.0373641810014394 4553 2030670 SGTC_1100 amiodarone 5.07 µM -1.78403638007664 0.0332820195362871 no 3206 0.0372088769187568 4642 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2162 5663267 200 µM -1.78433308211698 0.033259630129066 no 3207 0.0371847788355701 4633 6456493 SGTC_832 4083-0019 164 µM -1.78624400865487 0.0331157269304141 no 3208 0.0370298791517491 4655 1990758 SGTC_78 0336-0123 156.75 µM -1.78746271809314 0.0330242196357428 no 3209 0.0369313663140417 4502 6765896 SGTC_3109 9122853 49.47 µM -1.78805051837157 0.0329801589526303 no 3210 0.0368839288705924 4639 1234709 SGTC_2246 7293507 91.5585 µM -1.79271504275078 0.0326322276807148 no 3211 0.0365092499795156 4637 887656 SGTC_1825 st052143 62.6 µM -1.79557397392432 0.0324204775271183 no 3212 0.0362811490777857 4661 674173 SGTC_723 4182-0001 115 µM -1.79892884245875 0.032173442210727 no 3213 0.0360149687337413 4619 744821 YLR208W SEC13 SGTC_3059 1327-0034 3 µM -1.79994400158516 0.0320989980504305 no 3214 0.0359347404194633 4489 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1855 st056195 39.6 µM -1.80246316728184 0.0319148754893978 no 3215 0.0357362823309374 4567 4028379 SGTC_1930 st074634 34.3 µM -1.80331769188312 0.0318526178661687 no 3216 0.0356691678469701 4544 684253 YOR116C RPO31 SGTC_2225 6654152 15.4 µM -1.80664541440028 0.0316111271231942 no 3217 0.0354087918508602 4588 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_817 1391-0715 46 µM -1.81185119528202 0.0312363833039854 no 3218 0.0350045960910254 4620 1353946 SGTC_1432 4049-0298 68.4 µM -1.81215020315172 0.0312149709570415 no 3219 0.0349814955023397 4661 741646 SGTC_1622 st003707 19.4 µM -1.81307550568473 0.0311487857294558 no 3220 0.0349100882373247 4635 10140899 SGTC_1225 1216-0074 20.6 µM -1.81366456592184 0.0311067118166885 no 3221 0.0348646917602267 4618 4241466 SGTC_131 0141-0277 33.849 µM -1.81672102215661 0.0308891571769319 no 3222 0.0346299205771082 4589 1547771 SGTC_1683 st010134 710 nM -1.82115453085072 0.0305758252903047 no 3223 0.0342916850021966 4602 3818134 SGTC_1464 k208-0027 110 µM -1.82562087268955 0.0302628393405031 no 3224 0.0339536947634715 4623 X1464 SGTC_3311 9131146 2.8755 µM -1.82725712335322 0.0301488430986888 no 3225 0.0338305593412425 4600 4900406 YPR165W RHO1 SGTC_3000 9075062 71.4286 µM -1.83571429975571 0.029565299381031 no 3226 0.03319996096916 4627 17057871 SGTC_2138 5575593 77.673 µM -1.83648186590125 0.0295128046697152 no 3227 0.0331432108305413 4633 762213 SGTC_99 0109-0120 622.8 µM -1.84801951942551 0.0287330105999232 no 3228 0.0322997595661687 4647 759414 SGTC_2849 9019321 12.99 µM -1.85047443535775 0.0285693202338367 no 3229 0.0321225996724982 4636 16489627 SGTC_220 paclitaxel 373.376 µM -1.85285808547562 0.0284111247362188 no 3230 0.0319513510682811 4621 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.85462382249474 0.0282944087415963 no 3231 0.0318249819066083 4662 1273210 SGTC_1375 2910-0797 186 µM -1.85950962230211 0.0279735334127283 no 3232 0.0314774683156592 4646 742508 SGTC_1771 st048882 4.1505 µM -1.86307729653564 0.0277411454776674 no 3233 0.0312256959697352 4661 4580403 SGTC_2954 9074818 52.69 µM -1.86762167662967 0.0274474695131702 no 3234 0.0309074114015368 4633 16648742 SGTC_960 1222-0186 7.7 µM -1.87766079588807 0.0268078827472806 no 3235 0.0302137915404859 4630 3126296 SGTC_868 0527-0199 213 µM -1.87842084945273 0.0267599711258688 no 3236 0.0301618077591566 4638 2849450 SGTC_3102 9121669 49.47 µM -1.88435305199858 0.0263884736190539 no 3237 0.029758617882592 4675 41905072 SGTC_324 1315-0088 19.6 µM -1.89423997230322 0.0257788984664819 no 3238 0.0290965823310095 4651 6787421 SGTC_2720 fluspirilene 36.88 µM -1.89963626929642 0.0254511924838917 no 3239 0.0287404345507746 4662 3396 An atypical antipsychotic. SGTC_1419 3993-2473 62.6 µM -1.90235718775041 0.0252872843268073 no 3240 0.0285622370016636 4721 704026 SGTC_378 3970-0959 8.33 µM -1.90913332135175 0.0248829301509837 no 3241 0.0281224476054607 4663 6615653 SGTC_1699 st031318 29.054 µM -1.91043380861167 0.0248059492661437 no 3242 0.0280386906423094 4701 5340658 SGTC_3237 9133362 49.47 µM -1.91215824564335 0.0247041812851758 no 3243 0.0279279499390839 4662 43845137 SGTC_185 k048-0037 25.491 µM -1.91447852901525 0.0245678022388062 no 3244 0.0277795200026644 4694 6827589 SGTC_2766 oltipraz 83.91 µM -1.91669070883581 0.0244383660857064 no 3245 0.0276386181669206 4637 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_392 N-ethylmaleimide 8.33 µM -1.91828741587548 0.0243452977825701 no 3246 0.0275372885956688 4658 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1673 st016611 27.3 µM -1.92026716110782 0.0242303164946579 no 3247 0.0274120810538697 4652 5226799 SGTC_1184 1269-1718 139 µM -1.92319436967689 0.0240611435975136 no 3248 0.0272278220491727 4691 5403821 SGTC_1213 1315-0166 115 µM -1.92612030417161 0.0238930371629385 no 3249 0.0270446769568026 4647 768401 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.93577727918054 0.023345195977264 no 3250 0.0264474924136173 4653 6312947 SGTC_278 4092-0821 23.9 µM -1.93633229847107 0.0233140335725805 no 3251 0.0264135077177997 4647 877900 SGTC_2655 perillic acid 100 µM -1.93821712714682 0.0232084681918349 no 3252 0.0262983690250721 4702 5702197 An apoptosis inducer. SGTC_111 0083-0039 52.457 µM -1.9384532963361 0.0231952692537793 no 3253 0.0262839717604952 4653 759313 SGTC_1090 efavirenz 20.7 µM -1.94629500578579 0.022760589602371 no 3254 0.0258096565833087 4694 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1414 3917-0015 5.4 µM -1.95276710838518 0.0224070195283383 no 3255 0.0254235988235117 4689 6618702 SGTC_550 4123-0385 25.7 µM -1.9595106638972 0.0220435593388928 no 3256 0.0250265061292082 4683 5731123 SGTC_1627 st003713 25.6 µM -1.97220038287321 0.0213731031757593 no 3257 0.0242933679966656 4663 16195070 YER133W GLC7 SGTC_897 1000-0139 31.4 µM -1.978077757509 0.0210684649747318 no 3258 0.0239599676800878 4645 6151020 SGTC_2709 st078560 56 µM -1.97895069462094 0.0210235334557249 no 3259 0.0239107788875062 4648 17250903 SGTC_387 norethindrone acetate 66.7 µM -1.97898507268911 0.021021765620453 no 3260 0.0239088434694897 4676 541197 SGTC_2677 mitomycin C 100 µM -1.98240591483719 0.0208464824056037 no 3261 0.0237169140659605 4731 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_907 3448-6986 75.5 µM -1.98509585273339 0.0207095210191862 no 3262 0.0235669040668358 4681 590582 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.98586555109842 0.0206704714155589 no 3263 0.0235241273722634 4686 5393153 SGTC_2621 lithochol-11-enic acid 100 µM -1.99090971688228 0.0204161029543242 no 3264 0.0232454068769621 4624 6708711 SGTC_909 3448-9333 149 µM -2.00043927912549 0.019942780215667 no 3265 0.0227264252597656 4631 3344074 SGTC_773 4358-1457 44.6 µM -2.00212557645617 0.0198600007271087 no 3266 0.0226356136970038 4676 1186886 SGTC_1791 st048313 56.1 µM -2.0127932635837 0.0193430583549104 no 3267 0.0220681914509693 4705 1204976 SGTC_1065 prochlorperazine maleate 2.48 µM -2.03621488609509 0.0182480695952169 no 3268 0.0208643910546952 4726 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3286 9117135 37.221 µM -2.03867361029131 0.0181362461026808 no 3269 0.0207413066172347 4641 3438150 SGTC_1021 4476-0760 85.3 µM -2.04676672051555 0.0177722853890417 no 3270 0.0203404973475682 4712 746768 SGTC_1071 trifluoperazine 6.31 µM -2.04802666632986 0.0177161878637655 no 3271 0.0202786932873082 4715 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1922 5578187 25 µM -2.05666134656113 0.0173357905266879 no 3272 0.0198594063738677 4666 1350412 SGTC_2375 9072683 200 µM -2.05684925931012 0.0173275902788796 no 3273 0.0198503640334431 4723 16798029 SGTC_993 3909-8757 62.7 µM -2.05786543884346 0.0172833030138697 no 3274 0.0198015261020509 4682 4288324 YLR208W SEC13 SGTC_2963 9082507 9 µM -2.05949751370799 0.0172123760870047 no 3275 0.0197233014749017 4664 16459611 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -2.07829436450501 0.0164132655292467 no 3276 0.0188411275961142 4611 4330530 SGTC_688 0527-0193 473 µM -2.09264924465273 0.0158245872497605 no 3277 0.0181902385824395 4719 4007154 SGTC_1409 3909-8004 61.9 µM -2.09482485539013 0.0157369670325309 no 3278 0.0180932823737527 4735 2119279 SGTC_627 1391-0720 175 µM -2.10127289369244 0.015479720134492 no 3279 0.0178085088974097 4711 997839 SGTC_812 4251-0442 148 µM -2.1039244148884 0.0153749887945407 no 3280 0.0176925204367713 4719 5723007 SGTC_1294 1000-1494 117 µM -2.13961283574966 0.01402349131415 no 3281 0.0161930342148105 4731 712797 YDL207W GLE1 SGTC_1454 4239-0054 42.6 µM -2.14089633558822 0.0139768564243206 no 3282 0.0161411993628203 4739 1340767 SGTC_2818 7996756 12.99 µM -2.16137295409084 0.0132507397582847 no 3283 0.0153332707857954 4710 2241621 SGTC_3030 9087619 49.47 µM -2.16474619043524 0.0131343032930711 no 3284 0.0152035638252358 4706 25236973 SGTC_820 1582-0060 59.9 µM -2.16860137220306 0.0130023148596784 no 3285 0.0150564804575107 4731 3848840 SGTC_2929 9013348 24.6 µM -2.17880070220039 0.0126586404591417 no 3286 0.0146732383885731 4688 2995952 SGTC_1215 3852-0577 11.2 µM -2.18296087618131 0.0125207337930737 no 3287 0.0145193456523186 4730 2884876 SGTC_3035 9091303 49.47 µM -2.20599683329807 0.0117804171159941 no 3288 0.0136921107167933 4751 25237002 SGTC_1426 4048-4480 71.7 µM -2.20641934534954 0.0117672012135328 no 3289 0.0136773258757885 4741 14224343 SGTC_2091 4-phenylthiadiazole 200 µM -2.21448974997961 0.0115172229597055 no 3290 0.0133975535194858 4736 270010 SGTC_1781 st038725 66.3 µM -2.26884527872254 0.00995064423528533 no 3291 0.011638868198142 4718 4270275 YIL048W NEO1 SGTC_1701 st028638 40.4 µM -2.27726021948542 0.00972554178950789 no 3292 0.0113853454823507 4739 3490878 SGTC_2895 9054447 58.44 µM -2.28827664923171 0.00943758135505438 no 3293 0.0110607077311678 4757 2697450 SGTC_722 3534-0461 190 µM -2.30705969433762 0.00896378040896318 no 3294 0.0105257462520369 4738 658262 SGTC_236 1509-0011 5.31 µM -2.32876036455218 0.00844244039254138 no 3295 0.00993588211456106 4741 3107280 SGTC_964 1287-0107 19.4 µM -2.33652254231084 0.00826253004777142 no 3296 0.00973201207008436 4730 51516812 YPR165W RHO1 SGTC_2294 7971431 200 µM -2.34507947010642 0.00806810939382855 no 3297 0.00951151223220741 4733 5741572 SGTC_930 2810-3379 265 µM -2.38061758601756 0.00730302856490823 no 3298 0.00864182197922861 4733 1015764 SGTC_1239 0337-0584 35.4 µM -2.38120462548722 0.00729094674574646 no 3299 0.00862806171899995 4744 914301 YML130C ERO1 SGTC_2424 5537928 59.2 µM -2.39521485386734 0.00700778485801894 no 3300 0.00830531431232813 4744 5382802 SGTC_226 1,3-diallylurea 8.28947 mM -2.40289940798136 0.00685663102711323 no 3301 0.00813283052545315 4750 74537 YKL182W FAS1 SGTC_2765 myclobutanil 7.74 µM -2.40767992826799 0.00676405852064494 no 3302 0.00802712454234218 4740 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2456 5770359 74.46 µM -2.42249342873221 0.00648417679599146 no 3303 0.00770720227316943 4735 3118787 SGTC_1911 st060208 74.3 µM -2.42642894323209 0.00641156433850486 no 3304 0.00762411799472409 4751 688783 SGTC_2580 diallyl disulphide 81.36 µM -2.43720605566282 0.00621639060451297 no 3305 0.00740062121269242 4733 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2837 9008476 45.46 µM -2.45009317280889 0.0059899263963849 no 3306 0.00714096264418757 4722 2992805 SGTC_3108 9121785 49.47 µM -2.46914422126208 0.00566853873091236 no 3307 0.00677183105983948 4691 17140271 SGTC_1878 temozolomide 1 mM -2.48332478479003 0.0054393498912593 no 3308 0.00650811754404042 4756 5394 DNA alkylating agent. SGTC_251 melphalan 456.522 µM -2.49000636169625 0.00533424418018148 no 3309 0.00638704043895953 4772 460612 A DNA alkylator. SGTC_31 0508-1974 57.237 µM -2.51275607067578 0.00498978965397549 no 3310 0.00598960660621844 4744 6810525 SGTC_1553 gossypol 38.6 µM -2.51920100195054 0.00489587762259325 no 3311 0.00588107451008865 4760 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1749 st037932 54.2 µM -2.52523007815918 0.00480945452718897 no 3312 0.00578112820918772 4740 594497 SGTC_2894 9048625 32.47 µM -2.53478998249248 0.0046752053244383 no 3313 0.0056257379652529 4765 4092861 SGTC_3356 9151811 4.48 µM -2.56433504703966 0.00428118783099291 no 3314 0.00516868513740518 4781 1859254 YPR165W RHO1 SGTC_2253 7938677 135.83 µM -2.60906939165295 0.00374097502886074 no 3315 0.00453944149305544 4776 2301972 SGTC_712 r015-0009 80.6 µM -2.60946223565394 0.00373651491408907 no 3316 0.00453423274229368 4775 6813872 YLR060W FRS1 SGTC_2143 5623677 140.463 µM -2.62255392229826 0.00359058072778735 no 3317 0.00436367280688192 4769 5375313 SGTC_587 k089-0003 57 µM -2.65622572056389 0.00323845768073293 no 3318 0.00395103513615397 4749 9659696 SGTC_186 3455-3465 67.277 µM -2.66645833590755 0.0031377821660428 no 3319 0.00383275536158752 4796 755278 SGTC_189 3970-0742 2.116 µM -2.67408425743398 0.00306459482297987 no 3320 0.00374668110499813 4773 2891807 SGTC_3146 9095609 49.47 µM -2.67699073420238 0.00303710795752199 no 3321 0.00371433446722083 4761 17173999 SGTC_2913 7966556 36.57 µM -2.68109240093645 0.00299869584730885 no 3322 0.00366911251546895 4716 2976516 SGTC_729 4092-0585 94.1 µM -2.68141338188935 0.00299570840796429 no 3323 0.00366559454326873 4775 2169061 SGTC_685 1278-0033 54.9 µM -2.73244639058017 0.00255347745214063 no 3324 0.00314329506808475 4783 3590572 SGTC_2218 6965428 192.983 µM -2.77359109244607 0.00224087551061272 no 3325 0.00277206581581383 4751 675684 SGTC_1174 0739-0097 51.1 µM -2.81097000466402 0.00198739255743864 no 3326 0.00246961951647177 4788 728447 SGTC_181 1447-1644 8.07 µM -2.8251987557855 0.0018979520568188 no 3327 0.00236256479072283 4754 534600 SGTC_2781 5567276 71.43 µM -2.83521287377394 0.00183721446837189 no 3328 0.00228975798356362 4755 2853274 SGTC_2616 abietic acid 100 µM -2.88041466154726 0.00158445525415837 no 3329 0.00198576225896539 4779 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_507 nimesulide 162 µM -2.886403956417 0.00155345546698845 no 3330 0.00194835829289646 4783 4495 A COX2 inhibitor. SGTC_1520 flindersine 88 µM -2.92337857286812 0.00137401475546652 no 3331 0.00173127624108895 4781 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2714 st079313 56.9 µM -2.92542627937704 0.00136465367647658 no 3332 0.00171992333583152 4790 2939799 SGTC_2131 toluylene red 5.2905 µM -2.92744241967846 0.00135549386436058 no 3333 0.00170881168738603 4763 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2159 5658611 73.75 µM -2.9360264655956 0.00131711989066233 no 3334 0.00166222978999391 4788 793844 SGTC_3056 9094900 49.47 µM -3.04132893706498 0.00092068921497998 yes 3335 0.00117768180211097 4788 25236784 SGTC_382 3229-0966 23.2 µM -3.0522784698229 0.000886493579583431 yes 3336 0.00113555650236672 4799 5722370 SGTC_569 4130-2812 160 µM -3.09371936243098 0.000767376004273276 yes 3337 0.000988321825112276 4778 743552 SGTC_2996 9066192 71.4286 µM -3.10547473959797 0.000736376817279583 yes 3338 0.000949869232046541 4774 6472854 SGTC_1069 diphenylcyclopropenone 8.49 µM -3.11178800697245 0.00072020891506022 yes 3339 0.000929789921126058 4798 65057 A dermal irritant. YDR527W RBA50 SGTC_101 0490-5701 117.494 µM -3.1596872097752 0.000607799236157115 yes 3340 0.000789692984981681 4778 4661669 SGTC_174 3553-0389 74.3 µM -3.17057084849498 0.0005846280514933 yes 3341 0.000760698634634859 4794 738071 SGTC_41 0478-0632 82.643 µM -3.20672532488307 0.000513387745031419 yes 3342 0.000671275589762533 4784 3750424 SGTC_228 caffeine 993.056 µM -3.23876681972348 0.000457056840589119 yes 3343 0.000600238377390168 4802 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2464 5717415 7.67 µM -3.30159293602068 0.000362860901152793 yes 3344 0.000480687400832955 4789 5285744 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -3.32160112840123 0.000336875471435305 yes 3345 0.000447512707344166 4802 688751 SGTC_110 0850-0284 111.64 µM -3.36676104818375 0.000284451782476576 yes 3346 0.000380282796820323 4801 3906265 SGTC_2607 solasodine 47.35 µM -3.49794034632493 0.000172073764582081 yes 3347 0.000234432996098187 4774 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3207 9114163 49.47 µM -3.55500435069882 0.000137553554039222 yes 3348 0.00018898641753865 4783 849233 SGTC_1645 Cervolide 78 µM -3.62445415380737 0.000104291965216622 yes 3349 0.000144786189579127 4809 23173 A fragrance. SGTC_112 phenothiazine 287.218 µM -4.04457444478292 1.76611570827647e-05 yes 3350 2.62091252787833e-05 4805 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3050 9093513 49.47 µM -4.1179579353296 1.27213354871816e-05 yes 3351 1.91122221886711e-05 4803 25236664 SGTC_105 0111-0055 734.78 µM -4.3437438227745 4.48301350796677e-06 yes 3352 7.00374250859146e-06 4807 5179370 SGTC_965 1291-5240 308 µM -4.37816449972003 3.80699643015938e-06 yes 3353 5.98415018466388e-06 4803 2834598